id sid tid token lemma pos cord-023095-4dannjjm 1 1 key key NN cord-023095-4dannjjm 1 2 : : : cord-023095-4dannjjm 2 1 cord-023095 cord-023095 NNP cord-023095-4dannjjm 2 2 - - HYPH cord-023095-4dannjjm 2 3 4dannjjm 4dannjjm CD cord-023095-4dannjjm 3 1 authors author NNS cord-023095-4dannjjm 3 2 : : : cord-023095-4dannjjm 4 1 nan nan NNP cord-023095-4dannjjm 4 2 title title NN cord-023095-4dannjjm 4 3 : : : cord-023095-4dannjjm 4 4 Research Research NNP cord-023095-4dannjjm 4 5 Abstract Abstract NNP cord-023095-4dannjjm 4 6 Program Program NNP cord-023095-4dannjjm 4 7 of of IN cord-023095-4dannjjm 4 8 the the DT cord-023095-4dannjjm 4 9 2011 2011 CD cord-023095-4dannjjm 4 10 ACVIM ACVIM NNP cord-023095-4dannjjm 4 11 Forum Forum NNP cord-023095-4dannjjm 4 12 Denver Denver NNP cord-023095-4dannjjm 4 13 , , , cord-023095-4dannjjm 4 14 Colorado Colorado NNP cord-023095-4dannjjm 4 15 , , , cord-023095-4dannjjm 4 16 June June NNP cord-023095-4dannjjm 4 17 15–18 15–18 CD cord-023095-4dannjjm 4 18 , , , cord-023095-4dannjjm 4 19 2011 2011 CD cord-023095-4dannjjm 4 20 date date NN cord-023095-4dannjjm 4 21 : : : cord-023095-4dannjjm 4 22 2011 2011 CD cord-023095-4dannjjm 4 23 - - SYM cord-023095-4dannjjm 4 24 05 05 CD cord-023095-4dannjjm 4 25 - - HYPH cord-023095-4dannjjm 4 26 03 03 CD cord-023095-4dannjjm 4 27 journal journal NN cord-023095-4dannjjm 4 28 : : : cord-023095-4dannjjm 4 29 J J NNP cord-023095-4dannjjm 4 30 Vet Vet NNP cord-023095-4dannjjm 4 31 Intern Intern NNP cord-023095-4dannjjm 4 32 Med Med NNP cord-023095-4dannjjm 4 33 DOI doi NN cord-023095-4dannjjm 4 34 : : : cord-023095-4dannjjm 5 1 10.1111 10.1111 CD cord-023095-4dannjjm 5 2 / / SYM cord-023095-4dannjjm 5 3 j.1939 j.1939 NNP cord-023095-4dannjjm 5 4 - - HYPH cord-023095-4dannjjm 5 5 1676.2011.0726.x 1676.2011.0726.x CD cord-023095-4dannjjm 5 6 sha sha NNP cord-023095-4dannjjm 5 7 : : : cord-023095-4dannjjm 5 8 1707777971b3b3830a3beebff709bafe5942b15f 1707777971b3b3830a3beebff709bafe5942b15f CD cord-023095-4dannjjm 6 1 doc_id doc_id CD cord-023095-4dannjjm 6 2 : : : cord-023095-4dannjjm 6 3 23095 23095 CD cord-023095-4dannjjm 6 4 cord_uid cord_uid NNS cord-023095-4dannjjm 6 5 : : : cord-023095-4dannjjm 7 1 4dannjjm 4dannjjm CD cord-023095-4dannjjm 8 1 nan nan NNP cord-023095-4dannjjm 8 2 Clinics Clinics NNP cord-023095-4dannjjm 8 3 ÃÃ ÃÃ NNP cord-023095-4dannjjm 8 4 Also also RB cord-023095-4dannjjm 8 5 see see VB cord-023095-4dannjjm 8 6 Infectious Infectious NNP cord-023095-4dannjjm 8 7 Disease Disease NNP cord-023095-4dannjjm 8 8 abstracts abstract NNS cord-023095-4dannjjm 8 9 ID-1 ID-1 NNP cord-023095-4dannjjm 8 10 -ID-14 -ID-14 NNP cord-023095-4dannjjm 9 1 ( ( -LRB- cord-023095-4dannjjm 9 2 Thursday Thursday NNP cord-023095-4dannjjm 9 3 , , , cord-023095-4dannjjm 9 4 June June NNP cord-023095-4dannjjm 9 5 16 16 CD cord-023095-4dannjjm 9 6 , , , cord-023095-4dannjjm 9 7 2:15 2:15 CD cord-023095-4dannjjm 9 8 pm pm NN cord-023095-4dannjjm 10 1 -6:15 -6:15 RB cord-023095-4dannjjm 11 1 pm pm NNP cord-023095-4dannjjm 11 2 ) ) -RRB- cord-023095-4dannjjm 12 1 ÃÃ ÃÃ NNP cord-023095-4dannjjm 12 2 Also also RB cord-023095-4dannjjm 12 3 see see VB cord-023095-4dannjjm 12 4 Pharmacology Pharmacology NNP cord-023095-4dannjjm 12 5 abstracts abstract NNS cord-023095-4dannjjm 12 6 P-1 P-1 NNP cord-023095-4dannjjm 12 7 -P-5 -p-5 NN cord-023095-4dannjjm 12 8 ( ( -LRB- cord-023095-4dannjjm 12 9 Thursday Thursday NNP cord-023095-4dannjjm 12 10 , , , cord-023095-4dannjjm 12 11 June June NNP cord-023095-4dannjjm 12 12 16 16 CD cord-023095-4dannjjm 12 13 , , , cord-023095-4dannjjm 12 14 5:00 5:00 CD cord-023095-4dannjjm 12 15 pm pm NN cord-023095-4dannjjm 13 1 -6:15 -6:15 RB cord-023095-4dannjjm 14 1 pm pm NNP cord-023095-4dannjjm 14 2 ) ) -RRB- cord-023095-4dannjjm 15 1 ÃÃ ÃÃ NNP cord-023095-4dannjjm 15 2 Also also RB cord-023095-4dannjjm 15 3 see see VB cord-023095-4dannjjm 15 4 Gasteroenterology Gasteroenterology NNP cord-023095-4dannjjm 15 5 abstracts abstract NNS cord-023095-4dannjjm 15 6 GI-1 GI-1 NNP cord-023095-4dannjjm 15 7 - - HYPH cord-023095-4dannjjm 15 8 June June NNP cord-023095-4dannjjm 15 9 17 17 CD cord-023095-4dannjjm 15 10 , , , cord-023095-4dannjjm 15 11 8 8 CD cord-023095-4dannjjm 15 12 Hypertrophic hypertrophic JJ cord-023095-4dannjjm 15 13 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 15 14 ( ( -LRB- cord-023095-4dannjjm 15 15 HCM HCM NNP cord-023095-4dannjjm 15 16 ) ) -RRB- cord-023095-4dannjjm 16 1 is be VBZ cord-023095-4dannjjm 16 2 the the DT cord-023095-4dannjjm 16 3 most most RBS cord-023095-4dannjjm 16 4 commonly commonly RB cord-023095-4dannjjm 16 5 observed observe VBN cord-023095-4dannjjm 16 6 myocardial myocardial JJ cord-023095-4dannjjm 16 7 disease disease NN cord-023095-4dannjjm 16 8 in in IN cord-023095-4dannjjm 16 9 cats cat NNS cord-023095-4dannjjm 16 10 . . . cord-023095-4dannjjm 17 1 Beta beta NN cord-023095-4dannjjm 17 2 - - HYPH cord-023095-4dannjjm 17 3 blockers blocker NNS cord-023095-4dannjjm 17 4 and and CC cord-023095-4dannjjm 17 5 calcium calcium NN cord-023095-4dannjjm 17 6 channel channel NN cord-023095-4dannjjm 17 7 inhibitors inhibitor NNS cord-023095-4dannjjm 17 8 are be VBP cord-023095-4dannjjm 17 9 frequently frequently RB cord-023095-4dannjjm 17 10 administered administer VBN cord-023095-4dannjjm 17 11 drugs drug NNS cord-023095-4dannjjm 17 12 to to IN cord-023095-4dannjjm 17 13 cats cat NNS cord-023095-4dannjjm 17 14 with with IN cord-023095-4dannjjm 17 15 preclinical preclinical JJ cord-023095-4dannjjm 17 16 HCM HCM NNP cord-023095-4dannjjm 17 17 despite despite IN cord-023095-4dannjjm 17 18 the the DT cord-023095-4dannjjm 17 19 fact fact NN cord-023095-4dannjjm 17 20 that that IN cord-023095-4dannjjm 17 21 neither neither DT cord-023095-4dannjjm 17 22 drug drug NN cord-023095-4dannjjm 17 23 category category NN cord-023095-4dannjjm 17 24 has have VBZ cord-023095-4dannjjm 17 25 been be VBN cord-023095-4dannjjm 17 26 proven prove VBN cord-023095-4dannjjm 17 27 to to TO cord-023095-4dannjjm 17 28 slow slow VB cord-023095-4dannjjm 17 29 disease disease NN cord-023095-4dannjjm 17 30 progression progression NN cord-023095-4dannjjm 17 31 or or CC cord-023095-4dannjjm 17 32 improve improve VB cord-023095-4dannjjm 17 33 survival survival NN cord-023095-4dannjjm 17 34 . . . cord-023095-4dannjjm 18 1 Ivabradine Ivabradine NNP cord-023095-4dannjjm 18 2 ( ( -LRB- cord-023095-4dannjjm 18 3 Procorolan Procorolan NNP cord-023095-4dannjjm 18 4 s s NNP cord-023095-4dannjjm 18 5 , , , cord-023095-4dannjjm 18 6 Servier Servier NNP cord-023095-4dannjjm 18 7 , , , cord-023095-4dannjjm 18 8 France France NNP cord-023095-4dannjjm 18 9 ) ) -RRB- cord-023095-4dannjjm 18 10 is be VBZ cord-023095-4dannjjm 18 11 a a DT cord-023095-4dannjjm 18 12 novel novel JJ cord-023095-4dannjjm 18 13 negative negative JJ cord-023095-4dannjjm 18 14 chronotropic chronotropic JJ cord-023095-4dannjjm 18 15 agent agent NN cord-023095-4dannjjm 18 16 used use VBN cord-023095-4dannjjm 18 17 in in IN cord-023095-4dannjjm 18 18 the the DT cord-023095-4dannjjm 18 19 treatment treatment NN cord-023095-4dannjjm 18 20 of of IN cord-023095-4dannjjm 18 21 ischemic ischemic JJ cord-023095-4dannjjm 18 22 heart heart NN cord-023095-4dannjjm 18 23 disease disease NN cord-023095-4dannjjm 18 24 in in IN cord-023095-4dannjjm 18 25 people people NNS cord-023095-4dannjjm 18 26 . . . cord-023095-4dannjjm 19 1 Little little JJ cord-023095-4dannjjm 19 2 is be VBZ cord-023095-4dannjjm 19 3 known know VBN cord-023095-4dannjjm 19 4 about about IN cord-023095-4dannjjm 19 5 its -PRON- PRP$ cord-023095-4dannjjm 19 6 efficacy efficacy NN cord-023095-4dannjjm 19 7 and and CC cord-023095-4dannjjm 19 8 safety safety NN cord-023095-4dannjjm 19 9 in in IN cord-023095-4dannjjm 19 10 cats cat NNS cord-023095-4dannjjm 19 11 . . . cord-023095-4dannjjm 20 1 The the DT cord-023095-4dannjjm 20 2 purpose purpose NN cord-023095-4dannjjm 20 3 of of IN cord-023095-4dannjjm 20 4 this this DT cord-023095-4dannjjm 20 5 study study NN cord-023095-4dannjjm 20 6 was be VBD cord-023095-4dannjjm 20 7 to to TO cord-023095-4dannjjm 20 8 determine determine VB cord-023095-4dannjjm 20 9 the the DT cord-023095-4dannjjm 20 10 short short JJ cord-023095-4dannjjm 20 11 - - HYPH cord-023095-4dannjjm 20 12 term term NN cord-023095-4dannjjm 20 13 effects effect NNS cord-023095-4dannjjm 20 14 of of IN cord-023095-4dannjjm 20 15 ivabradine ivabradine NN cord-023095-4dannjjm 20 16 on on IN cord-023095-4dannjjm 20 17 heart heart NN cord-023095-4dannjjm 20 18 rate rate NN cord-023095-4dannjjm 20 19 ( ( -LRB- cord-023095-4dannjjm 20 20 HR HR NNP cord-023095-4dannjjm 20 21 ) ) -RRB- cord-023095-4dannjjm 20 22 , , , cord-023095-4dannjjm 20 23 blood blood NN cord-023095-4dannjjm 20 24 pressure pressure NN cord-023095-4dannjjm 20 25 , , , cord-023095-4dannjjm 20 26 left leave VBN cord-023095-4dannjjm 20 27 ventricular ventricular JJ cord-023095-4dannjjm 20 28 ( ( -LRB- cord-023095-4dannjjm 20 29 LV LV NNP cord-023095-4dannjjm 20 30 ) ) -RRB- cord-023095-4dannjjm 20 31 systolic systolic JJ cord-023095-4dannjjm 20 32 and and CC cord-023095-4dannjjm 20 33 diastolic diastolic JJ cord-023095-4dannjjm 20 34 function function NN cord-023095-4dannjjm 20 35 , , , cord-023095-4dannjjm 20 36 left leave VBN cord-023095-4dannjjm 20 37 atrial atrial JJ cord-023095-4dannjjm 20 38 ( ( -LRB- cord-023095-4dannjjm 20 39 LA LA NNP cord-023095-4dannjjm 20 40 ) ) -RRB- cord-023095-4dannjjm 20 41 performance performance NN cord-023095-4dannjjm 20 42 , , , cord-023095-4dannjjm 20 43 and and CC cord-023095-4dannjjm 20 44 clinical clinical JJ cord-023095-4dannjjm 20 45 tolerance tolerance NN cord-023095-4dannjjm 20 46 in in IN cord-023095-4dannjjm 20 47 healthy healthy JJ cord-023095-4dannjjm 20 48 cats cat NNS cord-023095-4dannjjm 20 49 after after IN cord-023095-4dannjjm 20 50 repeated repeat VBN cord-023095-4dannjjm 20 51 oral oral JJ cord-023095-4dannjjm 20 52 doses dose NNS cord-023095-4dannjjm 20 53 . . . cord-023095-4dannjjm 21 1 Ten ten CD cord-023095-4dannjjm 21 2 healthy healthy JJ cord-023095-4dannjjm 21 3 laboratory laboratory NN cord-023095-4dannjjm 21 4 cats cat NNS cord-023095-4dannjjm 21 5 were be VBD cord-023095-4dannjjm 21 6 involved involve VBN cord-023095-4dannjjm 21 7 in in IN cord-023095-4dannjjm 21 8 the the DT cord-023095-4dannjjm 21 9 present present JJ cord-023095-4dannjjm 21 10 study study NN cord-023095-4dannjjm 21 11 . . . cord-023095-4dannjjm 22 1 Physical physical JJ cord-023095-4dannjjm 22 2 examination examination NN cord-023095-4dannjjm 22 3 , , , cord-023095-4dannjjm 22 4 systolic systolic JJ cord-023095-4dannjjm 22 5 blood blood NN cord-023095-4dannjjm 22 6 pressure pressure NN cord-023095-4dannjjm 22 7 measurement measurement NN cord-023095-4dannjjm 22 8 , , , cord-023095-4dannjjm 22 9 and and CC cord-023095-4dannjjm 22 10 transthoracic transthoracic NNP cord-023095-4dannjjm 22 11 echocardiography echocardiography NN cord-023095-4dannjjm 22 12 were be VBD cord-023095-4dannjjm 22 13 performed perform VBN cord-023095-4dannjjm 22 14 in in IN cord-023095-4dannjjm 22 15 all all DT cord-023095-4dannjjm 22 16 cats cat NNS cord-023095-4dannjjm 22 17 at at IN cord-023095-4dannjjm 22 18 baseline baseline NN cord-023095-4dannjjm 22 19 and and CC cord-023095-4dannjjm 22 20 after after IN cord-023095-4dannjjm 22 21 oral oral JJ cord-023095-4dannjjm 22 22 administration administration NN cord-023095-4dannjjm 22 23 ( ( -LRB- cord-023095-4dannjjm 22 24 4 4 CD cord-023095-4dannjjm 22 25 weeks week NNS cord-023095-4dannjjm 22 26 each each DT cord-023095-4dannjjm 22 27 ) ) -RRB- cord-023095-4dannjjm 22 28 of of IN cord-023095-4dannjjm 22 29 ivabradine ivabradine NNP cord-023095-4dannjjm 22 30 ( ( -LRB- cord-023095-4dannjjm 22 31 0.3 0.3 CD cord-023095-4dannjjm 22 32 mg mg NNP cord-023095-4dannjjm 22 33 / / SYM cord-023095-4dannjjm 22 34 kg kg NNP cord-023095-4dannjjm 22 35 , , , cord-023095-4dannjjm 22 36 q12 q12 NN cord-023095-4dannjjm 22 37 h h NNP cord-023095-4dannjjm 22 38 ) ) -RRB- cord-023095-4dannjjm 22 39 and and CC cord-023095-4dannjjm 22 40 atenolol atenolol NNP cord-023095-4dannjjm 22 41 ( ( -LRB- cord-023095-4dannjjm 22 42 6.25 6.25 CD cord-023095-4dannjjm 22 43 mg mg NN cord-023095-4dannjjm 22 44 / / SYM cord-023095-4dannjjm 22 45 cat cat NN cord-023095-4dannjjm 22 46 , , , cord-023095-4dannjjm 22 47 q12h q12h XX cord-023095-4dannjjm 22 48 ; ; : cord-023095-4dannjjm 22 49 1.0 1.0 CD cord-023095-4dannjjm 22 50 - - SYM cord-023095-4dannjjm 22 51 1.7 1.7 CD cord-023095-4dannjjm 22 52 mg mg NNP cord-023095-4dannjjm 22 53 / / SYM cord-023095-4dannjjm 22 54 kg kg NNP cord-023095-4dannjjm 22 55 ) ) -RRB- cord-023095-4dannjjm 22 56 in in IN cord-023095-4dannjjm 22 57 a a DT cord-023095-4dannjjm 22 58 prospective prospective JJ cord-023095-4dannjjm 22 59 , , , cord-023095-4dannjjm 22 60 double double JJ cord-023095-4dannjjm 22 61 - - HYPH cord-023095-4dannjjm 22 62 blind blind JJ cord-023095-4dannjjm 22 63 , , , cord-023095-4dannjjm 22 64 randomized randomized JJ cord-023095-4dannjjm 22 65 , , , cord-023095-4dannjjm 22 66 active active JJ cord-023095-4dannjjm 22 67 - - HYPH cord-023095-4dannjjm 22 68 control control NN cord-023095-4dannjjm 22 69 , , , cord-023095-4dannjjm 22 70 fully fully RB cord-023095-4dannjjm 22 71 crossed cross VBD cord-023095-4dannjjm 22 72 study study NN cord-023095-4dannjjm 22 73 . . . cord-023095-4dannjjm 23 1 A a LS cord-023095-4dannjjm 23 2 - - HYPH cord-023095-4dannjjm 23 3 priori priori FW cord-023095-4dannjjm 23 4 non non JJ cord-023095-4dannjjm 23 5 - - JJ cord-023095-4dannjjm 23 6 inferiority inferiority JJ cord-023095-4dannjjm 23 7 margins margin NNS cord-023095-4dannjjm 23 8 for for IN cord-023095-4dannjjm 23 9 the the DT cord-023095-4dannjjm 23 10 effects effect NNS cord-023095-4dannjjm 23 11 of of IN cord-023095-4dannjjm 23 12 ivabradine ivabradine NN cord-023095-4dannjjm 24 1 compared compare VBN cord-023095-4dannjjm 24 2 to to IN cord-023095-4dannjjm 24 3 atenolol atenolol NN cord-023095-4dannjjm 24 4 were be VBD cord-023095-4dannjjm 24 5 set set VBN cord-023095-4dannjjm 24 6 at at IN cord-023095-4dannjjm 24 7 50 50 CD cord-023095-4dannjjm 24 8 % % NN cord-023095-4dannjjm 24 9 ( ( -LRB- cord-023095-4dannjjm 24 10 f f NNP cord-023095-4dannjjm 24 11 5 5 CD cord-023095-4dannjjm 24 12 0.5 0.5 CD cord-023095-4dannjjm 24 13 ) ) -RRB- cord-023095-4dannjjm 24 14 based base VBN cord-023095-4dannjjm 24 15 on on IN cord-023095-4dannjjm 24 16 predicted predict VBN cord-023095-4dannjjm 24 17 clinical clinical JJ cord-023095-4dannjjm 24 18 relevance relevance NN cord-023095-4dannjjm 24 19 , , , cord-023095-4dannjjm 24 20 observer observer NN cord-023095-4dannjjm 24 21 measurement measurement NN cord-023095-4dannjjm 24 22 variability variability NN cord-023095-4dannjjm 24 23 , , , cord-023095-4dannjjm 24 24 and and CC cord-023095-4dannjjm 24 25 in in IN cord-023095-4dannjjm 24 26 agreement agreement NN cord-023095-4dannjjm 24 27 with with IN cord-023095-4dannjjm 24 28 FDA FDA NNP cord-023095-4dannjjm 24 29 guidelines guideline NNS cord-023095-4dannjjm 24 30 . . . cord-023095-4dannjjm 25 1 Variables variable NNS cord-023095-4dannjjm 25 2 were be VBD cord-023095-4dannjjm 25 3 compared compare VBN cord-023095-4dannjjm 25 4 by by IN cord-023095-4dannjjm 25 5 use use NN cord-023095-4dannjjm 25 6 of of IN cord-023095-4dannjjm 25 7 2-way 2-way JJ cord-023095-4dannjjm 25 8 repeated repeat VBN cord-023095-4dannjjm 25 9 measures measure NNS cord-023095-4dannjjm 25 10 ANOVA ANOVA NNP cord-023095-4dannjjm 25 11 . . . cord-023095-4dannjjm 26 1 Ivabradine Ivabradine NNP cord-023095-4dannjjm 26 2 was be VBD cord-023095-4dannjjm 26 3 clinically clinically RB cord-023095-4dannjjm 26 4 well well RB cord-023095-4dannjjm 26 5 tolerated tolerate VBN cord-023095-4dannjjm 26 6 with with IN cord-023095-4dannjjm 26 7 no no DT cord-023095-4dannjjm 26 8 adverse adverse JJ cord-023095-4dannjjm 26 9 events event NNS cord-023095-4dannjjm 26 10 observed observe VBD cord-023095-4dannjjm 26 11 . . . cord-023095-4dannjjm 27 1 HR HR NNP cord-023095-4dannjjm 27 2 ( ( -LRB- cord-023095-4dannjjm 27 3 ivabradine ivabradine FW cord-023095-4dannjjm 27 4 , , , cord-023095-4dannjjm 27 5 Po0.001 Po0.001 NNP cord-023095-4dannjjm 27 6 ; ; : cord-023095-4dannjjm 27 7 atenolol atenolol NN cord-023095-4dannjjm 27 8 , , , cord-023095-4dannjjm 27 9 Po0.001 Po0.001 NNP cord-023095-4dannjjm 27 10 ; ; : cord-023095-4dannjjm 27 11 ivabradine ivabradine FW cord-023095-4dannjjm 27 12 vs. vs. FW cord-023095-4dannjjm 27 13 atenolol atenolol NN cord-023095-4dannjjm 27 14 , , , cord-023095-4dannjjm 27 15 P p NN cord-023095-4dannjjm 27 16 5 5 CD cord-023095-4dannjjm 27 17 0.721 0.721 CD cord-023095-4dannjjm 27 18 ) ) -RRB- cord-023095-4dannjjm 27 19 and and CC cord-023095-4dannjjm 27 20 rate rate NN cord-023095-4dannjjm 27 21 - - HYPH cord-023095-4dannjjm 27 22 pressure pressure NN cord-023095-4dannjjm 27 23 product product NN cord-023095-4dannjjm 27 24 ( ( -LRB- cord-023095-4dannjjm 27 25 ivabradine ivabradine FW cord-023095-4dannjjm 27 26 , , , cord-023095-4dannjjm 27 27 P p NN cord-023095-4dannjjm 27 28 o o NN cord-023095-4dannjjm 27 29 0.001 0.001 CD cord-023095-4dannjjm 27 30 ; ; : cord-023095-4dannjjm 27 31 atenolol atenolol NN cord-023095-4dannjjm 27 32 , , , cord-023095-4dannjjm 27 33 P p NN cord-023095-4dannjjm 27 34 5 5 CD cord-023095-4dannjjm 27 35 0.001 0.001 CD cord-023095-4dannjjm 27 36 ; ; : cord-023095-4dannjjm 27 37 ivabradine ivabradine FW cord-023095-4dannjjm 27 38 vs. vs. FW cord-023095-4dannjjm 27 39 atenolol atenolol NN cord-023095-4dannjjm 27 40 , , , cord-023095-4dannjjm 27 41 P p NN cord-023095-4dannjjm 27 42 5 5 CD cord-023095-4dannjjm 27 43 0.847 0.847 CD cord-023095-4dannjjm 27 44 ) ) -RRB- cord-023095-4dannjjm 27 45 were be VBD cord-023095-4dannjjm 27 46 not not RB cord-023095-4dannjjm 27 47 different different JJ cord-023095-4dannjjm 27 48 between between IN cord-023095-4dannjjm 27 49 treatments treatment NNS cord-023095-4dannjjm 27 50 . . . cord-023095-4dannjjm 28 1 At at IN cord-023095-4dannjjm 28 2 the the DT cord-023095-4dannjjm 28 3 dosages dosage NNS cord-023095-4dannjjm 28 4 used use VBN cord-023095-4dannjjm 28 5 , , , cord-023095-4dannjjm 28 6 ivabradine ivabradine NNP cord-023095-4dannjjm 28 7 demonstrated demonstrate VBD cord-023095-4dannjjm 28 8 more more RBR cord-023095-4dannjjm 28 9 favorable favorable JJ cord-023095-4dannjjm 28 10 effects effect NNS cord-023095-4dannjjm 28 11 than than IN cord-023095-4dannjjm 28 12 atenolol atenolol NN cord-023095-4dannjjm 28 13 on on IN cord-023095-4dannjjm 28 14 echocardiographic echocardiographic JJ cord-023095-4dannjjm 28 15 indices index NNS cord-023095-4dannjjm 28 16 of of IN cord-023095-4dannjjm 28 17 left left JJ cord-023095-4dannjjm 28 18 ventricular ventricular JJ cord-023095-4dannjjm 28 19 ( ( -LRB- cord-023095-4dannjjm 28 20 LV LV NNP cord-023095-4dannjjm 28 21 ) ) -RRB- cord-023095-4dannjjm 28 22 systolic systolic JJ cord-023095-4dannjjm 28 23 and and CC cord-023095-4dannjjm 28 24 diastolic diastolic JJ cord-023095-4dannjjm 28 25 function function NN cord-023095-4dannjjm 28 26 and and CC cord-023095-4dannjjm 28 27 left leave VBN cord-023095-4dannjjm 28 28 atrial atrial JJ cord-023095-4dannjjm 28 29 performance performance NN cord-023095-4dannjjm 28 30 . . . cord-023095-4dannjjm 29 1 Ivabradine Ivabradine NNP cord-023095-4dannjjm 29 2 is be VBZ cord-023095-4dannjjm 29 3 non non JJ cord-023095-4dannjjm 29 4 - - JJ cord-023095-4dannjjm 29 5 inferior inferior JJ cord-023095-4dannjjm 29 6 to to IN cord-023095-4dannjjm 29 7 atenolol atenolol NN cord-023095-4dannjjm 29 8 with with IN cord-023095-4dannjjm 29 9 regard regard NN cord-023095-4dannjjm 29 10 to to IN cord-023095-4dannjjm 29 11 effects effect NNS cord-023095-4dannjjm 29 12 on on IN cord-023095-4dannjjm 29 13 HR hr NN cord-023095-4dannjjm 29 14 , , , cord-023095-4dannjjm 29 15 rate rate NN cord-023095-4dannjjm 29 16 - - HYPH cord-023095-4dannjjm 29 17 pressure pressure NN cord-023095-4dannjjm 29 18 product product NN cord-023095-4dannjjm 29 19 , , , cord-023095-4dannjjm 29 20 LV LV NNP cord-023095-4dannjjm 29 21 function function NN cord-023095-4dannjjm 29 22 , , , cord-023095-4dannjjm 29 23 LA LA NNP cord-023095-4dannjjm 29 24 performance performance NN cord-023095-4dannjjm 29 25 , , , cord-023095-4dannjjm 29 26 and and CC cord-023095-4dannjjm 29 27 clinical clinical JJ cord-023095-4dannjjm 29 28 tolerance tolerance NN cord-023095-4dannjjm 29 29 . . . cord-023095-4dannjjm 30 1 Clinical clinical JJ cord-023095-4dannjjm 30 2 studies study NNS cord-023095-4dannjjm 30 3 in in IN cord-023095-4dannjjm 30 4 cats cat NNS cord-023095-4dannjjm 30 5 with with IN cord-023095-4dannjjm 30 6 HCM HCM NNP cord-023095-4dannjjm 30 7 are be VBP cord-023095-4dannjjm 30 8 needed need VBN cord-023095-4dannjjm 30 9 to to TO cord-023095-4dannjjm 30 10 validate validate VB cord-023095-4dannjjm 30 11 these these DT cord-023095-4dannjjm 30 12 findings finding NNS cord-023095-4dannjjm 30 13 and and CC cord-023095-4dannjjm 30 14 further further RB cord-023095-4dannjjm 30 15 assess assess VB cord-023095-4dannjjm 30 16 safety safety NN cord-023095-4dannjjm 30 17 . . . cord-023095-4dannjjm 31 1 The the DT cord-023095-4dannjjm 31 2 aim aim NN cord-023095-4dannjjm 31 3 of of IN cord-023095-4dannjjm 31 4 this this DT cord-023095-4dannjjm 31 5 study study NN cord-023095-4dannjjm 31 6 was be VBD cord-023095-4dannjjm 31 7 to to TO cord-023095-4dannjjm 31 8 compare compare VB cord-023095-4dannjjm 31 9 outcome outcome NN cord-023095-4dannjjm 31 10 from from IN cord-023095-4dannjjm 31 11 CPA cpa NN cord-023095-4dannjjm 31 12 in in IN cord-023095-4dannjjm 31 13 dogs dog NNS cord-023095-4dannjjm 31 14 following follow VBG cord-023095-4dannjjm 31 15 initial initial JJ cord-023095-4dannjjm 31 16 administration administration NN cord-023095-4dannjjm 31 17 of of IN cord-023095-4dannjjm 31 18 either either CC cord-023095-4dannjjm 31 19 epinephrine epinephrine NN cord-023095-4dannjjm 31 20 or or CC cord-023095-4dannjjm 31 21 vasopressin vasopressin NN cord-023095-4dannjjm 31 22 during during IN cord-023095-4dannjjm 31 23 cardiopulmonary cardiopulmonary JJ cord-023095-4dannjjm 31 24 resuscitation resuscitation NN cord-023095-4dannjjm 31 25 ( ( -LRB- cord-023095-4dannjjm 31 26 CPR CPR NNP cord-023095-4dannjjm 31 27 ) ) -RRB- cord-023095-4dannjjm 31 28 . . . cord-023095-4dannjjm 32 1 Dogs dog NNS cord-023095-4dannjjm 32 2 having have VBG cord-023095-4dannjjm 32 3 CPA cpa NN cord-023095-4dannjjm 32 4 in in IN cord-023095-4dannjjm 32 5 the the DT cord-023095-4dannjjm 32 6 ER ER NNP cord-023095-4dannjjm 32 7 or or CC cord-023095-4dannjjm 32 8 ICU ICU NNP cord-023095-4dannjjm 32 9 of of IN cord-023095-4dannjjm 32 10 a a DT cord-023095-4dannjjm 32 11 university university NN cord-023095-4dannjjm 32 12 hospital hospital NN cord-023095-4dannjjm 32 13 were be VBD cord-023095-4dannjjm 32 14 randomized randomize VBN cord-023095-4dannjjm 32 15 to to TO cord-023095-4dannjjm 32 16 receive receive VB cord-023095-4dannjjm 32 17 either either CC cord-023095-4dannjjm 32 18 IV IV NNP cord-023095-4dannjjm 32 19 epinephrine epinephrine NN cord-023095-4dannjjm 32 20 ( ( -LRB- cord-023095-4dannjjm 32 21 0.01 0.01 CD cord-023095-4dannjjm 32 22 - - SYM cord-023095-4dannjjm 32 23 0.02 0.02 CD cord-023095-4dannjjm 32 24 mg mg NNP cord-023095-4dannjjm 32 25 / / SYM cord-023095-4dannjjm 32 26 kg kg NNP cord-023095-4dannjjm 32 27 ) ) -RRB- cord-023095-4dannjjm 32 28 or or CC cord-023095-4dannjjm 32 29 vasopressin vasopressin NN cord-023095-4dannjjm 32 30 ( ( -LRB- cord-023095-4dannjjm 32 31 0.5 0.5 CD cord-023095-4dannjjm 32 32 - - SYM cord-023095-4dannjjm 32 33 1.0 1.0 CD cord-023095-4dannjjm 32 34 U U NNP cord-023095-4dannjjm 32 35 / / SYM cord-023095-4dannjjm 32 36 kg kg NNP cord-023095-4dannjjm 32 37 ) ) -RRB- cord-023095-4dannjjm 32 38 in in IN cord-023095-4dannjjm 32 39 a a DT cord-023095-4dannjjm 32 40 blinded blinded JJ cord-023095-4dannjjm 32 41 fashion fashion NN cord-023095-4dannjjm 32 42 immediately immediately RB cord-023095-4dannjjm 32 43 following follow VBG cord-023095-4dannjjm 32 44 establishment establishment NN cord-023095-4dannjjm 32 45 of of IN cord-023095-4dannjjm 32 46 IV IV NNP cord-023095-4dannjjm 32 47 access access NN cord-023095-4dannjjm 32 48 and and CC cord-023095-4dannjjm 32 49 again again RB cord-023095-4dannjjm 32 50 three three CD cord-023095-4dannjjm 32 51 minutes minute NNS cord-023095-4dannjjm 32 52 later later RB cord-023095-4dannjjm 32 53 . . . cord-023095-4dannjjm 33 1 A a DT cord-023095-4dannjjm 33 2 standardized standardized JJ cord-023095-4dannjjm 33 3 CPR CPR NNP cord-023095-4dannjjm 33 4 protocol protocol NN cord-023095-4dannjjm 33 5 was be VBD cord-023095-4dannjjm 33 6 followed follow VBN cord-023095-4dannjjm 33 7 . . . cord-023095-4dannjjm 34 1 Other other JJ cord-023095-4dannjjm 34 2 vasopressors vasopressor NNS cord-023095-4dannjjm 34 3 were be VBD cord-023095-4dannjjm 34 4 not not RB cord-023095-4dannjjm 34 5 permitted permit VBN cord-023095-4dannjjm 34 6 during during IN cord-023095-4dannjjm 34 7 the the DT cord-023095-4dannjjm 34 8 six six CD cord-023095-4dannjjm 34 9 minute minute NN cord-023095-4dannjjm 34 10 study study NN cord-023095-4dannjjm 34 11 period period NN cord-023095-4dannjjm 34 12 , , , cord-023095-4dannjjm 34 13 at at IN cord-023095-4dannjjm 34 14 the the DT cord-023095-4dannjjm 34 15 end end NN cord-023095-4dannjjm 34 16 of of IN cord-023095-4dannjjm 34 17 the the DT cord-023095-4dannjjm 34 18 study study NN cord-023095-4dannjjm 34 19 period period NN cord-023095-4dannjjm 34 20 additional additional JJ cord-023095-4dannjjm 34 21 CPR CPR NNP cord-023095-4dannjjm 34 22 interventions intervention NNS cord-023095-4dannjjm 34 23 were be VBD cord-023095-4dannjjm 34 24 at at IN cord-023095-4dannjjm 34 25 the the DT cord-023095-4dannjjm 34 26 discretion discretion NN cord-023095-4dannjjm 34 27 of of IN cord-023095-4dannjjm 34 28 the the DT cord-023095-4dannjjm 34 29 managing managing NN cord-023095-4dannjjm 34 30 clinician clinician NN cord-023095-4dannjjm 34 31 . . . cord-023095-4dannjjm 35 1 The the DT cord-023095-4dannjjm 35 2 primary primary JJ cord-023095-4dannjjm 35 3 end end NN cord-023095-4dannjjm 35 4 point point NN cord-023095-4dannjjm 35 5 was be VBD cord-023095-4dannjjm 35 6 return return NN cord-023095-4dannjjm 35 7 of of IN cord-023095-4dannjjm 35 8 spontaneous spontaneous JJ cord-023095-4dannjjm 35 9 circulation circulation NN cord-023095-4dannjjm 35 10 ( ( -LRB- cord-023095-4dannjjm 35 11 ROSC ROSC NNP cord-023095-4dannjjm 35 12 ) ) -RRB- cord-023095-4dannjjm 35 13 within within IN cord-023095-4dannjjm 35 14 the the DT cord-023095-4dannjjm 35 15 study study NN cord-023095-4dannjjm 35 16 period period NN cord-023095-4dannjjm 35 17 ; ; , cord-023095-4dannjjm 35 18 secondary secondary JJ cord-023095-4dannjjm 35 19 end end NN cord-023095-4dannjjm 35 20 points point NNS cord-023095-4dannjjm 35 21 included include VBN cord-023095-4dannjjm 35 22 ROSC ROSC NNP cord-023095-4dannjjm 35 23 at at IN cord-023095-4dannjjm 35 24 any any DT cord-023095-4dannjjm 35 25 point point NN cord-023095-4dannjjm 35 26 , , , cord-023095-4dannjjm 35 27 survival survival NN cord-023095-4dannjjm 35 28 to to IN cord-023095-4dannjjm 35 29 20 20 CD cord-023095-4dannjjm 35 30 minutes minute NNS cord-023095-4dannjjm 35 31 , , , cord-023095-4dannjjm 35 32 and and CC cord-023095-4dannjjm 35 33 survival survival NN cord-023095-4dannjjm 35 34 to to IN cord-023095-4dannjjm 35 35 one one CD cord-023095-4dannjjm 35 36 hour hour NN cord-023095-4dannjjm 35 37 . . . cord-023095-4dannjjm 36 1 Sixty sixty JJ cord-023095-4dannjjm 36 2 dogs dog NNS cord-023095-4dannjjm 36 3 completed complete VBD cord-023095-4dannjjm 36 4 the the DT cord-023095-4dannjjm 36 5 study study NN cord-023095-4dannjjm 36 6 , , , cord-023095-4dannjjm 36 7 31 31 CD cord-023095-4dannjjm 36 8 received receive VBD cord-023095-4dannjjm 36 9 epinephrine epinephrine NN cord-023095-4dannjjm 36 10 and and CC cord-023095-4dannjjm 36 11 29 29 CD cord-023095-4dannjjm 36 12 received receive VBD cord-023095-4dannjjm 36 13 vasopressin vasopressin NN cord-023095-4dannjjm 36 14 . . . cord-023095-4dannjjm 37 1 ROSC rosc JJ cord-023095-4dannjjm 37 2 within within IN cord-023095-4dannjjm 37 3 six six CD cord-023095-4dannjjm 37 4 minutes minute NNS cord-023095-4dannjjm 37 5 was be VBD cord-023095-4dannjjm 37 6 53 53 CD cord-023095-4dannjjm 37 7 % % NN cord-023095-4dannjjm 37 8 ( ( -LRB- cord-023095-4dannjjm 37 9 13 13 CD cord-023095-4dannjjm 37 10 vasopressin vasopressin NN cord-023095-4dannjjm 37 11 , , , cord-023095-4dannjjm 37 12 19 19 CD cord-023095-4dannjjm 37 13 epinephrine epinephrine NN cord-023095-4dannjjm 37 14 p p NN cord-023095-4dannjjm 37 15 5 5 CD cord-023095-4dannjjm 37 16 0.2 0.2 CD cord-023095-4dannjjm 37 17 ) ) -RRB- cord-023095-4dannjjm 37 18 , , , cord-023095-4dannjjm 37 19 ROSC ROSC NNP cord-023095-4dannjjm 37 20 at at IN cord-023095-4dannjjm 37 21 any any DT cord-023095-4dannjjm 37 22 time time NN cord-023095-4dannjjm 37 23 was be VBD cord-023095-4dannjjm 37 24 60 60 CD cord-023095-4dannjjm 37 25 % % NN cord-023095-4dannjjm 37 26 ( ( -LRB- cord-023095-4dannjjm 37 27 15 15 CD cord-023095-4dannjjm 37 28 vasopressin vasopressin NN cord-023095-4dannjjm 37 29 , , , cord-023095-4dannjjm 37 30 21 21 CD cord-023095-4dannjjm 37 31 epinephrine epinephrine NN cord-023095-4dannjjm 37 32 p p NN cord-023095-4dannjjm 37 33 5 5 CD cord-023095-4dannjjm 37 34 0.2 0.2 CD cord-023095-4dannjjm 37 35 ) ) -RRB- cord-023095-4dannjjm 37 36 . . . cord-023095-4dannjjm 38 1 Survival survival NN cord-023095-4dannjjm 38 2 to to IN cord-023095-4dannjjm 38 3 20 20 CD cord-023095-4dannjjm 38 4 minutes minute NNS cord-023095-4dannjjm 38 5 was be VBD cord-023095-4dannjjm 38 6 32 32 CD cord-023095-4dannjjm 38 7 % % NN cord-023095-4dannjjm 38 8 ( ( -LRB- cord-023095-4dannjjm 38 9 6 6 CD cord-023095-4dannjjm 38 10 vasopressin vasopressin NN cord-023095-4dannjjm 38 11 , , , cord-023095-4dannjjm 38 12 13 13 CD cord-023095-4dannjjm 38 13 epinephrine epinephrine NN cord-023095-4dannjjm 38 14 p p NN cord-023095-4dannjjm 38 15 5 5 CD cord-023095-4dannjjm 38 16 0.077 0.077 CD cord-023095-4dannjjm 38 17 ) ) -RRB- cord-023095-4dannjjm 38 18 , , , cord-023095-4dannjjm 38 19 survival survival NN cord-023095-4dannjjm 38 20 to to IN cord-023095-4dannjjm 38 21 one one CD cord-023095-4dannjjm 38 22 hour hour NN cord-023095-4dannjjm 38 23 was be VBD cord-023095-4dannjjm 38 24 18 18 CD cord-023095-4dannjjm 38 25 % % NN cord-023095-4dannjjm 38 26 ( ( -LRB- cord-023095-4dannjjm 38 27 2 2 CD cord-023095-4dannjjm 38 28 vasopressin vasopressin NN cord-023095-4dannjjm 38 29 , , , cord-023095-4dannjjm 38 30 9 9 CD cord-023095-4dannjjm 38 31 epinephrine epinephrine NN cord-023095-4dannjjm 38 32 p p NN cord-023095-4dannjjm 38 33 5 5 CD cord-023095-4dannjjm 38 34 0.027 0.027 CD cord-023095-4dannjjm 38 35 ) ) -RRB- cord-023095-4dannjjm 38 36 . . . cord-023095-4dannjjm 39 1 Five five CD cord-023095-4dannjjm 39 2 dogs dog NNS cord-023095-4dannjjm 39 3 survived survive VBD cord-023095-4dannjjm 39 4 to to IN cord-023095-4dannjjm 39 5 24 24 CD cord-023095-4dannjjm 39 6 hours hour NNS cord-023095-4dannjjm 39 7 , , , cord-023095-4dannjjm 39 8 one one CD cord-023095-4dannjjm 39 9 survived survive VBD cord-023095-4dannjjm 39 10 to to IN cord-023095-4dannjjm 39 11 hospital hospital NN cord-023095-4dannjjm 39 12 discharge discharge NN cord-023095-4dannjjm 39 13 . . . cord-023095-4dannjjm 40 1 Of of IN cord-023095-4dannjjm 40 2 animals animal NNS cord-023095-4dannjjm 40 3 dying die VBG cord-023095-4dannjjm 40 4 after after IN cord-023095-4dannjjm 40 5 ROSC ROSC NNP cord-023095-4dannjjm 40 6 , , , cord-023095-4dannjjm 40 7 13/35 13/35 CD cord-023095-4dannjjm 40 8 were be VBD cord-023095-4dannjjm 40 9 euthanized euthanize VBN cord-023095-4dannjjm 40 10 and and CC cord-023095-4dannjjm 40 11 22/35 22/35 CD cord-023095-4dannjjm 40 12 rearrested rearreste VBD cord-023095-4dannjjm 40 13 . . . cord-023095-4dannjjm 41 1 No no DT cord-023095-4dannjjm 41 2 advantage advantage NN cord-023095-4dannjjm 41 3 of of IN cord-023095-4dannjjm 41 4 routine routine JJ cord-023095-4dannjjm 41 5 substitution substitution NN cord-023095-4dannjjm 41 6 of of IN cord-023095-4dannjjm 41 7 vasopressin vasopressin NN cord-023095-4dannjjm 41 8 for for IN cord-023095-4dannjjm 41 9 epinephrine epinephrine NN cord-023095-4dannjjm 41 10 was be VBD cord-023095-4dannjjm 41 11 seen see VBN cord-023095-4dannjjm 41 12 for for IN cord-023095-4dannjjm 41 13 ROSC rosc NN cord-023095-4dannjjm 41 14 , , , cord-023095-4dannjjm 41 15 a a DT cord-023095-4dannjjm 41 16 small small JJ cord-023095-4dannjjm 41 17 survival survival NN cord-023095-4dannjjm 41 18 advantage advantage NN cord-023095-4dannjjm 41 19 at at IN cord-023095-4dannjjm 41 20 one one CD cord-023095-4dannjjm 41 21 hour hour NN cord-023095-4dannjjm 41 22 was be VBD cord-023095-4dannjjm 41 23 seen see VBN cord-023095-4dannjjm 41 24 in in IN cord-023095-4dannjjm 41 25 the the DT cord-023095-4dannjjm 41 26 group group NN cord-023095-4dannjjm 41 27 receiving receive VBG cord-023095-4dannjjm 41 28 epinephrine epinephrine NN cord-023095-4dannjjm 41 29 . . . cord-023095-4dannjjm 42 1 The the DT cord-023095-4dannjjm 42 2 study study NN cord-023095-4dannjjm 42 3 also also RB cord-023095-4dannjjm 42 4 demon demon NN cord-023095-4dannjjm 42 5 - - , cord-023095-4dannjjm 42 6 strated strate VBD cord-023095-4dannjjm 42 7 that that WDT cord-023095-4dannjjm 42 8 prospective prospective JJ cord-023095-4dannjjm 42 9 clinical clinical JJ cord-023095-4dannjjm 42 10 CPR CPR NNP cord-023095-4dannjjm 42 11 research research NN cord-023095-4dannjjm 42 12 in in IN cord-023095-4dannjjm 42 13 animals animal NNS cord-023095-4dannjjm 42 14 is be VBZ cord-023095-4dannjjm 42 15 both both DT cord-023095-4dannjjm 42 16 possible possible JJ cord-023095-4dannjjm 42 17 and and CC cord-023095-4dannjjm 42 18 practical practical JJ cord-023095-4dannjjm 42 19 . . . cord-023095-4dannjjm 43 1 Three three CD cord-023095-4dannjjm 43 2 dogs dog NNS cord-023095-4dannjjm 43 3 were be VBD cord-023095-4dannjjm 43 4 evaluated evaluate VBN cord-023095-4dannjjm 43 5 in in IN cord-023095-4dannjjm 43 6 3 3 CD cord-023095-4dannjjm 43 7 phases phase NNS cord-023095-4dannjjm 43 8 . . . cord-023095-4dannjjm 44 1 Phase-1 phase-1 NN cord-023095-4dannjjm 44 2 : : : cord-023095-4dannjjm 44 3 single single JJ cord-023095-4dannjjm 44 4 - - HYPH cord-023095-4dannjjm 44 5 dose dose NN cord-023095-4dannjjm 44 6 DiltXR DiltXR NNP cord-023095-4dannjjm 44 7 at at IN cord-023095-4dannjjm 44 8 approximately approximately RB cord-023095-4dannjjm 44 9 6 6 CD cord-023095-4dannjjm 44 10 mg mg NNS cord-023095-4dannjjm 44 11 / / SYM cord-023095-4dannjjm 44 12 kg kg NN cord-023095-4dannjjm 44 13 PO po NN cord-023095-4dannjjm 44 14 . . . cord-023095-4dannjjm 45 1 Phase-2 phase-2 NN cord-023095-4dannjjm 45 2 : : : cord-023095-4dannjjm 46 1 same same JJ cord-023095-4dannjjm 46 2 dose dose NN cord-023095-4dannjjm 46 3 q12h q12h NFP cord-023095-4dannjjm 46 4 for for IN cord-023095-4dannjjm 46 5 4.5 4.5 CD cord-023095-4dannjjm 46 6 days day NNS cord-023095-4dannjjm 46 7 . . . cord-023095-4dannjjm 47 1 Phase-3 Phase-3 NNP cord-023095-4dannjjm 47 2 : : : cord-023095-4dannjjm 47 3 after after IN cord-023095-4dannjjm 47 4 a a DT cord-023095-4dannjjm 47 5 14 14 CD cord-023095-4dannjjm 47 6 day day NN cord-023095-4dannjjm 47 7 wash wash NN cord-023095-4dannjjm 47 8 - - HYPH cord-023095-4dannjjm 47 9 out out RP cord-023095-4dannjjm 47 10 the the DT cord-023095-4dannjjm 47 11 single single JJ cord-023095-4dannjjm 47 12 - - HYPH cord-023095-4dannjjm 47 13 dose dose NN cord-023095-4dannjjm 47 14 protocol protocol NN cord-023095-4dannjjm 47 15 was be VBD cord-023095-4dannjjm 47 16 repeated repeat VBN cord-023095-4dannjjm 47 17 using use VBG cord-023095-4dannjjm 47 18 cut cut NN cord-023095-4dannjjm 47 19 tablets tablet NNS cord-023095-4dannjjm 47 20 to to TO cord-023095-4dannjjm 47 21 assess assess VB cord-023095-4dannjjm 47 22 affect affect NN cord-023095-4dannjjm 47 23 on on IN cord-023095-4dannjjm 47 24 extended extended JJ cord-023095-4dannjjm 47 25 release release NN cord-023095-4dannjjm 47 26 properties property NNS cord-023095-4dannjjm 47 27 . . . cord-023095-4dannjjm 48 1 Blood blood NN cord-023095-4dannjjm 48 2 pressure pressure NN cord-023095-4dannjjm 48 3 ( ( -LRB- cord-023095-4dannjjm 48 4 BP BP NNP cord-023095-4dannjjm 48 5 ) ) -RRB- cord-023095-4dannjjm 48 6 , , , cord-023095-4dannjjm 48 7 6-lead 6-lead CD cord-023095-4dannjjm 48 8 ECG ECG NNP cord-023095-4dannjjm 48 9 , , , cord-023095-4dannjjm 48 10 echocardiogram echocardiogram NN cord-023095-4dannjjm 48 11 , , , cord-023095-4dannjjm 48 12 and and CC cord-023095-4dannjjm 48 13 24h 24h NNS cord-023095-4dannjjm 48 14 - - HYPH cord-023095-4dannjjm 48 15 ambulatory ambulatory JJ cord-023095-4dannjjm 48 16 ECG ECG NNP cord-023095-4dannjjm 48 17 were be VBD cord-023095-4dannjjm 48 18 performed perform VBN cord-023095-4dannjjm 48 19 at at IN cord-023095-4dannjjm 48 20 baseline baseline NN cord-023095-4dannjjm 48 21 , , , cord-023095-4dannjjm 48 22 and and CC cord-023095-4dannjjm 48 23 conclusion conclusion NN cord-023095-4dannjjm 48 24 of of IN cord-023095-4dannjjm 48 25 Phase-2 Phase-2 NNP cord-023095-4dannjjm 48 26 . . . cord-023095-4dannjjm 49 1 Blood blood NN cord-023095-4dannjjm 49 2 samples sample NNS cord-023095-4dannjjm 49 3 and and CC cord-023095-4dannjjm 49 4 BP BP NNP cord-023095-4dannjjm 49 5 was be VBD cord-023095-4dannjjm 49 6 obtained obtain VBN cord-023095-4dannjjm 49 7 0 0 CD cord-023095-4dannjjm 49 8 , , , cord-023095-4dannjjm 49 9 1 1 CD cord-023095-4dannjjm 49 10 , , , cord-023095-4dannjjm 49 11 2 2 CD cord-023095-4dannjjm 49 12 , , , cord-023095-4dannjjm 49 13 4 4 CD cord-023095-4dannjjm 49 14 , , , cord-023095-4dannjjm 49 15 8 8 CD cord-023095-4dannjjm 49 16 , , , cord-023095-4dannjjm 49 17 12 12 CD cord-023095-4dannjjm 49 18 , , , cord-023095-4dannjjm 49 19 and and CC cord-023095-4dannjjm 49 20 24h 24h NNS cord-023095-4dannjjm 49 21 after after IN cord-023095-4dannjjm 49 22 final final JJ cord-023095-4dannjjm 49 23 dosing dosing NN cord-023095-4dannjjm 49 24 . . . cord-023095-4dannjjm 50 1 Peak peak JJ cord-023095-4dannjjm 50 2 median median JJ cord-023095-4dannjjm 50 3 plasma plasma NN cord-023095-4dannjjm 50 4 diltiazem diltiazem NN cord-023095-4dannjjm 50 5 concentrations concentration NNS cord-023095-4dannjjm 50 6 ( ( -LRB- cord-023095-4dannjjm 50 7 mcg mcg NNP cord-023095-4dannjjm 50 8 / / SYM cord-023095-4dannjjm 50 9 ml ml NN cord-023095-4dannjjm 50 10 ) ) -RRB- cord-023095-4dannjjm 50 11 measured measure VBN cord-023095-4dannjjm 50 12 by by IN cord-023095-4dannjjm 50 13 HPLC HPLC NNP cord-023095-4dannjjm 50 14 for for IN cord-023095-4dannjjm 50 15 each each DT cord-023095-4dannjjm 50 16 phase phase NN cord-023095-4dannjjm 50 17 were be VBD cord-023095-4dannjjm 50 18 0.0979 0.0979 CD cord-023095-4dannjjm 50 19 , , , cord-023095-4dannjjm 50 20 0.016 0.016 CD cord-023095-4dannjjm 50 21 , , , cord-023095-4dannjjm 50 22 and and CC cord-023095-4dannjjm 50 23 0.07 0.07 CD cord-023095-4dannjjm 50 24 respectively respectively RB cord-023095-4dannjjm 50 25 . . . cord-023095-4dannjjm 51 1 Diltiazem diltiazem NN cord-023095-4dannjjm 51 2 concentrations concentration NNS cord-023095-4dannjjm 51 3 were be VBD cord-023095-4dannjjm 51 4 below below IN cord-023095-4dannjjm 51 5 the the DT cord-023095-4dannjjm 51 6 limit limit NN cord-023095-4dannjjm 51 7 of of IN cord-023095-4dannjjm 51 8 detection detection NN cord-023095-4dannjjm 51 9 in in IN cord-023095-4dannjjm 51 10 the the DT cord-023095-4dannjjm 51 11 majority majority NN cord-023095-4dannjjm 51 12 of of IN cord-023095-4dannjjm 51 13 samples sample NNS cord-023095-4dannjjm 51 14 in in IN cord-023095-4dannjjm 51 15 phase-2 phase-2 NNP cord-023095-4dannjjm 51 16 . . . cord-023095-4dannjjm 52 1 Median median JJ cord-023095-4dannjjm 52 2 diltiazem diltiazem NN cord-023095-4dannjjm 52 3 concentration concentration NN cord-023095-4dannjjm 52 4 reached reach VBD cord-023095-4dannjjm 52 5 purported purport VBN cord-023095-4dannjjm 52 6 therapeutic therapeutic JJ cord-023095-4dannjjm 52 7 concentrations concentration NNS cord-023095-4dannjjm 52 8 ( ( -LRB- cord-023095-4dannjjm 52 9 0.05 0.05 CD cord-023095-4dannjjm 52 10 - - SYM cord-023095-4dannjjm 52 11 0.2 0.2 CD cord-023095-4dannjjm 52 12 mcg mcg NN cord-023095-4dannjjm 52 13 / / SYM cord-023095-4dannjjm 52 14 ml ml NNP cord-023095-4dannjjm 52 15 ) ) -RRB- cord-023095-4dannjjm 52 16 by by IN cord-023095-4dannjjm 52 17 2 2 CD cord-023095-4dannjjm 52 18 h h NN cord-023095-4dannjjm 52 19 post post JJ cord-023095-4dannjjm 52 20 - - JJ cord-023095-4dannjjm 52 21 pill pill NN cord-023095-4dannjjm 52 22 in in IN cord-023095-4dannjjm 52 23 phase-1 phase-1 NNP cord-023095-4dannjjm 52 24 and and CC cord-023095-4dannjjm 52 25 1h 1h CD cord-023095-4dannjjm 52 26 post post JJ cord-023095-4dannjjm 52 27 - - JJ cord-023095-4dannjjm 52 28 pill pill NN cord-023095-4dannjjm 52 29 in in IN cord-023095-4dannjjm 52 30 phase-3 phase-3 NNP cord-023095-4dannjjm 52 31 . . . cord-023095-4dannjjm 53 1 Therapeutic therapeutic JJ cord-023095-4dannjjm 53 2 concentrations concentration NNS cord-023095-4dannjjm 53 3 were be VBD cord-023095-4dannjjm 53 4 maintained maintain VBN cord-023095-4dannjjm 53 5 for for IN cord-023095-4dannjjm 53 6 24 24 CD cord-023095-4dannjjm 53 7 h h NN cord-023095-4dannjjm 53 8 in in IN cord-023095-4dannjjm 53 9 Phase-1 Phase-1 NNP cord-023095-4dannjjm 53 10 , , , cord-023095-4dannjjm 53 11 but but CC cord-023095-4dannjjm 53 12 only only RB cord-023095-4dannjjm 53 13 2h 2h CD cord-023095-4dannjjm 53 14 in in IN cord-023095-4dannjjm 53 15 phase-3 phase-3 NNP cord-023095-4dannjjm 53 16 . . . cord-023095-4dannjjm 54 1 Median median JJ cord-023095-4dannjjm 54 2 BP BP NNP cord-023095-4dannjjm 54 3 ( ( -LRB- cord-023095-4dannjjm 54 4 mmHg mmHg NNP cord-023095-4dannjjm 54 5 ) ) -RRB- cord-023095-4dannjjm 54 6 was be VBD cord-023095-4dannjjm 54 7 142.7 142.7 CD cord-023095-4dannjjm 54 8 at at IN cord-023095-4dannjjm 54 9 baseline baseline NN cord-023095-4dannjjm 54 10 and and CC cord-023095-4dannjjm 54 11 126.0 126.0 CD cord-023095-4dannjjm 54 12 at at IN cord-023095-4dannjjm 54 13 peak peak NN cord-023095-4dannjjm 54 14 concentration concentration NN cord-023095-4dannjjm 54 15 in in IN cord-023095-4dannjjm 54 16 phase-1 phase-1 NNP cord-023095-4dannjjm 54 17 . . . cord-023095-4dannjjm 55 1 Median median JJ cord-023095-4dannjjm 55 2 heart heart NN cord-023095-4dannjjm 55 3 rate rate NN cord-023095-4dannjjm 55 4 ( ( -LRB- cord-023095-4dannjjm 55 5 bpm bpm NNP cord-023095-4dannjjm 55 6 ) ) -RRB- cord-023095-4dannjjm 55 7 was be VBD cord-023095-4dannjjm 55 8 127.1 127.1 CD cord-023095-4dannjjm 55 9 at at IN cord-023095-4dannjjm 55 10 baseline baseline NN cord-023095-4dannjjm 55 11 . . . cord-023095-4dannjjm 56 1 24h 24h NNS cord-023095-4dannjjm 56 2 - - HYPH cord-023095-4dannjjm 56 3 ambulatory ambulatory JJ cord-023095-4dannjjm 56 4 ECG ECG NNP cord-023095-4dannjjm 56 5 analysis analysis NN cord-023095-4dannjjm 56 6 revealed reveal VBD cord-023095-4dannjjm 56 7 the the DT cord-023095-4dannjjm 56 8 median median JJ cord-023095-4dannjjm 56 9 hourly hourly JJ cord-023095-4dannjjm 56 10 heart heart NN cord-023095-4dannjjm 56 11 rate rate NN cord-023095-4dannjjm 56 12 was be VBD cord-023095-4dannjjm 56 13 101.5 101.5 CD cord-023095-4dannjjm 56 14 at at IN cord-023095-4dannjjm 56 15 baseline baseline NN cord-023095-4dannjjm 56 16 and and CC cord-023095-4dannjjm 56 17 102 102 CD cord-023095-4dannjjm 56 18 during during IN cord-023095-4dannjjm 56 19 phase-1 phase-1 NNP cord-023095-4dannjjm 56 20 . . . cord-023095-4dannjjm 57 1 Median median JJ cord-023095-4dannjjm 57 2 heart heart NN cord-023095-4dannjjm 57 3 rate rate NN cord-023095-4dannjjm 57 4 at at IN cord-023095-4dannjjm 57 5 peak peak NN cord-023095-4dannjjm 57 6 concentration concentration NN cord-023095-4dannjjm 57 7 in in IN cord-023095-4dannjjm 57 8 phase-1 phase-1 NNP cord-023095-4dannjjm 57 9 was be VBD cord-023095-4dannjjm 57 10 127.5 127.5 CD cord-023095-4dannjjm 57 11 . . . cord-023095-4dannjjm 58 1 Lack lack NN cord-023095-4dannjjm 58 2 of of IN cord-023095-4dannjjm 58 3 detectable detectable JJ cord-023095-4dannjjm 58 4 plasma plasma NN cord-023095-4dannjjm 58 5 diltiazem diltiazem NN cord-023095-4dannjjm 58 6 during during IN cord-023095-4dannjjm 58 7 phase-2 phase-2 NNP cord-023095-4dannjjm 58 8 may may MD cord-023095-4dannjjm 58 9 be be VB cord-023095-4dannjjm 58 10 due due JJ cord-023095-4dannjjm 58 11 to to IN cord-023095-4dannjjm 58 12 up up IN cord-023095-4dannjjm 58 13 - - HYPH cord-023095-4dannjjm 58 14 regulation regulation NN cord-023095-4dannjjm 58 15 of of IN cord-023095-4dannjjm 58 16 drug drug NN cord-023095-4dannjjm 58 17 metabolism metabolism NN cord-023095-4dannjjm 58 18 via via IN cord-023095-4dannjjm 58 19 P p NN cord-023095-4dannjjm 58 20 - - HYPH cord-023095-4dannjjm 58 21 glycoprotein glycoprotein NN cord-023095-4dannjjm 58 22 ( ( -LRB- cord-023095-4dannjjm 58 23 ABCB1 ABCB1 NNP cord-023095-4dannjjm 58 24 - - HYPH cord-023095-4dannjjm 58 25 1 1 CD cord-023095-4dannjjm 58 26 ) ) -RRB- cord-023095-4dannjjm 58 27 mutations mutation NNS cord-023095-4dannjjm 58 28 . . . cord-023095-4dannjjm 59 1 Ongoing ongoing JJ cord-023095-4dannjjm 59 2 data data NN cord-023095-4dannjjm 59 3 collection collection NN cord-023095-4dannjjm 59 4 and and CC cord-023095-4dannjjm 59 5 analysis analysis NN cord-023095-4dannjjm 59 6 will will MD cord-023095-4dannjjm 59 7 include include VB cord-023095-4dannjjm 59 8 mutation mutation NN cord-023095-4dannjjm 59 9 testing testing NN cord-023095-4dannjjm 59 10 . . . cord-023095-4dannjjm 60 1 Adiponectin Adiponectin NNP cord-023095-4dannjjm 60 2 ( ( -LRB- cord-023095-4dannjjm 60 3 ADPN ADPN NNP cord-023095-4dannjjm 60 4 ) ) -RRB- cord-023095-4dannjjm 60 5 is be VBZ cord-023095-4dannjjm 60 6 a a DT cord-023095-4dannjjm 60 7 cytokine cytokine NN cord-023095-4dannjjm 60 8 produced produce VBN cord-023095-4dannjjm 60 9 by by IN cord-023095-4dannjjm 60 10 fat fat JJ cord-023095-4dannjjm 60 11 cells cell NNS cord-023095-4dannjjm 60 12 which which WDT cord-023095-4dannjjm 60 13 has have VBZ cord-023095-4dannjjm 60 14 been be VBN cord-023095-4dannjjm 60 15 shown show VBN cord-023095-4dannjjm 60 16 to to TO cord-023095-4dannjjm 60 17 be be VB cord-023095-4dannjjm 60 18 correlated correlate VBN cord-023095-4dannjjm 60 19 with with IN cord-023095-4dannjjm 60 20 adverse adverse JJ cord-023095-4dannjjm 60 21 cardiac cardiac JJ cord-023095-4dannjjm 60 22 conditions condition NNS cord-023095-4dannjjm 60 23 in in IN cord-023095-4dannjjm 60 24 humans human NNS cord-023095-4dannjjm 60 25 . . . cord-023095-4dannjjm 61 1 In in IN cord-023095-4dannjjm 61 2 the the DT cord-023095-4dannjjm 61 3 heart heart NN cord-023095-4dannjjm 61 4 , , , cord-023095-4dannjjm 61 5 adiponectin adiponectin NN cord-023095-4dannjjm 61 6 activates activate VBZ cord-023095-4dannjjm 61 7 several several JJ cord-023095-4dannjjm 61 8 pro pro JJ cord-023095-4dannjjm 61 9 - - JJ cord-023095-4dannjjm 61 10 survival survival JJ cord-023095-4dannjjm 61 11 reactions reaction NNS cord-023095-4dannjjm 61 12 , , , cord-023095-4dannjjm 61 13 including include VBG cord-023095-4dannjjm 61 14 the the DT cord-023095-4dannjjm 61 15 AMPK AMPK NNP cord-023095-4dannjjm 61 16 pathway pathway NN cord-023095-4dannjjm 61 17 and and CC cord-023095-4dannjjm 61 18 COX2 cox2 JJ cord-023095-4dannjjm 61 19 receptors receptor NNS cord-023095-4dannjjm 61 20 , , , cord-023095-4dannjjm 61 21 which which WDT cord-023095-4dannjjm 61 22 protect protect VBP cord-023095-4dannjjm 61 23 the the DT cord-023095-4dannjjm 61 24 heart heart NN cord-023095-4dannjjm 61 25 following follow VBG cord-023095-4dannjjm 61 26 ischemic ischemic JJ cord-023095-4dannjjm 61 27 injury injury NN cord-023095-4dannjjm 61 28 . . . cord-023095-4dannjjm 62 1 Recent recent JJ cord-023095-4dannjjm 62 2 studies study NNS cord-023095-4dannjjm 62 3 have have VBP cord-023095-4dannjjm 62 4 shown show VBN cord-023095-4dannjjm 62 5 that that IN cord-023095-4dannjjm 62 6 higher high JJR cord-023095-4dannjjm 62 7 levels level NNS cord-023095-4dannjjm 62 8 of of IN cord-023095-4dannjjm 62 9 ADPN ADPN NNP cord-023095-4dannjjm 62 10 influence influence NN cord-023095-4dannjjm 62 11 cardiac cardiac JJ cord-023095-4dannjjm 62 12 remodeling remodeling NN cord-023095-4dannjjm 62 13 signaling signal VBG cord-023095-4dannjjm 62 14 , , , cord-023095-4dannjjm 62 15 inhibiting inhibit VBG cord-023095-4dannjjm 62 16 protein protein NN cord-023095-4dannjjm 62 17 synthesis synthesis NN cord-023095-4dannjjm 62 18 and and CC cord-023095-4dannjjm 62 19 suppressing suppress VBG cord-023095-4dannjjm 62 20 pathological pathological JJ cord-023095-4dannjjm 62 21 cardiac cardiac JJ cord-023095-4dannjjm 62 22 growth growth NN cord-023095-4dannjjm 62 23 . . . cord-023095-4dannjjm 63 1 In in IN cord-023095-4dannjjm 63 2 humans human NNS cord-023095-4dannjjm 63 3 , , , cord-023095-4dannjjm 63 4 ADPN ADPN NNP cord-023095-4dannjjm 63 5 plasma plasma NN cord-023095-4dannjjm 63 6 levels level NNS cord-023095-4dannjjm 63 7 rise rise VBP cord-023095-4dannjjm 63 8 with with IN cord-023095-4dannjjm 63 9 decreased decreased JJ cord-023095-4dannjjm 63 10 activity activity NN cord-023095-4dannjjm 63 11 of of IN cord-023095-4dannjjm 63 12 the the DT cord-023095-4dannjjm 63 13 sympathetic sympathetic JJ cord-023095-4dannjjm 63 14 nervous nervous JJ cord-023095-4dannjjm 63 15 system system NN cord-023095-4dannjjm 63 16 and and CC cord-023095-4dannjjm 63 17 b b NN cord-023095-4dannjjm 63 18 - - HYPH cord-023095-4dannjjm 63 19 adrenergic adrenergic NN cord-023095-4dannjjm 63 20 agonists agonist NNS cord-023095-4dannjjm 63 21 inhibit inhibit VBP cord-023095-4dannjjm 63 22 ADPN ADPN NNP cord-023095-4dannjjm 63 23 at at IN cord-023095-4dannjjm 63 24 the the DT cord-023095-4dannjjm 63 25 level level NN cord-023095-4dannjjm 63 26 of of IN cord-023095-4dannjjm 63 27 gene gene NN cord-023095-4dannjjm 63 28 expression expression NN cord-023095-4dannjjm 63 29 . . . cord-023095-4dannjjm 64 1 In in IN cord-023095-4dannjjm 64 2 contrast contrast NN cord-023095-4dannjjm 64 3 C c NN cord-023095-4dannjjm 64 4 - - HYPH cord-023095-4dannjjm 64 5 reactive reactive JJ cord-023095-4dannjjm 64 6 protein protein NN cord-023095-4dannjjm 64 7 ( ( -LRB- cord-023095-4dannjjm 64 8 CRP CRP NNP cord-023095-4dannjjm 64 9 ) ) -RRB- cord-023095-4dannjjm 64 10 , , , cord-023095-4dannjjm 64 11 a a DT cord-023095-4dannjjm 64 12 marker marker NN cord-023095-4dannjjm 64 13 of of IN cord-023095-4dannjjm 64 14 systemic systemic JJ cord-023095-4dannjjm 64 15 inflammation inflammation NN cord-023095-4dannjjm 64 16 is be VBZ cord-023095-4dannjjm 64 17 elevated elevate VBN cord-023095-4dannjjm 64 18 in in IN cord-023095-4dannjjm 64 19 humans human NNS cord-023095-4dannjjm 64 20 with with IN cord-023095-4dannjjm 64 21 congestive congestive JJ cord-023095-4dannjjm 64 22 heart heart NN cord-023095-4dannjjm 64 23 failure failure NN cord-023095-4dannjjm 64 24 ( ( -LRB- cord-023095-4dannjjm 64 25 CHF CHF NNP cord-023095-4dannjjm 64 26 ) ) -RRB- cord-023095-4dannjjm 64 27 and and CC cord-023095-4dannjjm 64 28 correlates correlate VBZ cord-023095-4dannjjm 64 29 to to IN cord-023095-4dannjjm 64 30 the the DT cord-023095-4dannjjm 64 31 severity severity NN cord-023095-4dannjjm 64 32 of of IN cord-023095-4dannjjm 64 33 disease disease NN cord-023095-4dannjjm 64 34 . . . cord-023095-4dannjjm 65 1 First first RB cord-023095-4dannjjm 65 2 , , , cord-023095-4dannjjm 65 3 we -PRON- PRP cord-023095-4dannjjm 65 4 hypothesized hypothesize VBD cord-023095-4dannjjm 65 5 that that IN cord-023095-4dannjjm 65 6 dogs dog NNS cord-023095-4dannjjm 65 7 with with IN cord-023095-4dannjjm 65 8 CHF CHF NNP cord-023095-4dannjjm 65 9 would would MD cord-023095-4dannjjm 65 10 have have VB cord-023095-4dannjjm 65 11 reduced reduce VBN cord-023095-4dannjjm 65 12 ADPN ADPN NNP cord-023095-4dannjjm 65 13 and and CC cord-023095-4dannjjm 65 14 elevated elevated JJ cord-023095-4dannjjm 65 15 CRP crp NN cord-023095-4dannjjm 65 16 compared compare VBN cord-023095-4dannjjm 65 17 to to IN cord-023095-4dannjjm 65 18 normal normal JJ cord-023095-4dannjjm 65 19 dogs dog NNS cord-023095-4dannjjm 65 20 and and CC cord-023095-4dannjjm 65 21 that that IN cord-023095-4dannjjm 65 22 cytokine cytokine NN cord-023095-4dannjjm 65 23 concentrations concentration NNS cord-023095-4dannjjm 65 24 would would MD cord-023095-4dannjjm 65 25 predict predict VB cord-023095-4dannjjm 65 26 severity severity NN cord-023095-4dannjjm 65 27 of of IN cord-023095-4dannjjm 65 28 CHF CHF NNP cord-023095-4dannjjm 65 29 . . . cord-023095-4dannjjm 66 1 Second second RB cord-023095-4dannjjm 66 2 , , , cord-023095-4dannjjm 66 3 we -PRON- PRP cord-023095-4dannjjm 66 4 hypothesized hypothesize VBD cord-023095-4dannjjm 66 5 that that IN cord-023095-4dannjjm 66 6 ADPN ADPN NNP cord-023095-4dannjjm 66 7 receptor-1 receptor-1 NNP cord-023095-4dannjjm 66 8 ( ( -LRB- cord-023095-4dannjjm 66 9 R1 R1 NNP cord-023095-4dannjjm 66 10 ) ) -RRB- cord-023095-4dannjjm 66 11 and and CC cord-023095-4dannjjm 66 12 ADPN ADPN NNP cord-023095-4dannjjm 66 13 protein protein NN cord-023095-4dannjjm 66 14 would would MD cord-023095-4dannjjm 66 15 be be VB cord-023095-4dannjjm 66 16 elevated elevate VBN cord-023095-4dannjjm 66 17 in in IN cord-023095-4dannjjm 66 18 the the DT cord-023095-4dannjjm 66 19 myocardium myocardium NN cord-023095-4dannjjm 66 20 of of IN cord-023095-4dannjjm 66 21 CHF CHF NNP cord-023095-4dannjjm 66 22 dogs dog NNS cord-023095-4dannjjm 66 23 reflecting reflect VBG cord-023095-4dannjjm 66 24 a a DT cord-023095-4dannjjm 66 25 compensatory compensatory JJ cord-023095-4dannjjm 66 26 process process NN cord-023095-4dannjjm 66 27 . . . cord-023095-4dannjjm 67 1 We -PRON- PRP cord-023095-4dannjjm 67 2 collected collect VBD cord-023095-4dannjjm 67 3 serum serum NN cord-023095-4dannjjm 67 4 from from IN cord-023095-4dannjjm 67 5 32 32 CD cord-023095-4dannjjm 67 6 dogs dog NNS cord-023095-4dannjjm 67 7 ( ( -LRB- cord-023095-4dannjjm 67 8 18 18 CD cord-023095-4dannjjm 67 9 healthy healthy JJ cord-023095-4dannjjm 67 10 and and CC cord-023095-4dannjjm 67 11 18 18 CD cord-023095-4dannjjm 67 12 CHF CHF NNP cord-023095-4dannjjm 67 13 ) ) -RRB- cord-023095-4dannjjm 67 14 . . . cord-023095-4dannjjm 68 1 Circulating circulate VBG cord-023095-4dannjjm 68 2 adiponectin adiponectin NN cord-023095-4dannjjm 68 3 and and CC cord-023095-4dannjjm 68 4 CRP crp NN cord-023095-4dannjjm 68 5 levels level NNS cord-023095-4dannjjm 68 6 were be VBD cord-023095-4dannjjm 68 7 quantified quantify VBN cord-023095-4dannjjm 68 8 using use VBG cord-023095-4dannjjm 68 9 a a DT cord-023095-4dannjjm 68 10 Mouse Mouse NNP cord-023095-4dannjjm 68 11 / / SYM cord-023095-4dannjjm 68 12 Rat Rat NNP cord-023095-4dannjjm 68 13 Adiponectin Adiponectin NNP cord-023095-4dannjjm 68 14 ELISA ELISA NNP cord-023095-4dannjjm 68 15 and and CC cord-023095-4dannjjm 68 16 a a DT cord-023095-4dannjjm 68 17 Canine Canine NNP cord-023095-4dannjjm 68 18 CRP CRP NNP cord-023095-4dannjjm 68 19 ELISA ELISA NNP cord-023095-4dannjjm 68 20 . . . cord-023095-4dannjjm 69 1 We -PRON- PRP cord-023095-4dannjjm 69 2 found find VBD cord-023095-4dannjjm 69 3 lower low JJR cord-023095-4dannjjm 69 4 mean mean JJ cord-023095-4dannjjm 69 5 CRP CRP NNP cord-023095-4dannjjm 69 6 concentrations concentration NNS cord-023095-4dannjjm 69 7 in in IN cord-023095-4dannjjm 69 8 normal normal JJ cord-023095-4dannjjm 69 9 dogs dog NNS cord-023095-4dannjjm 69 10 ( ( -LRB- cord-023095-4dannjjm 69 11 3.5 3.5 CD cord-023095-4dannjjm 69 12 AE AE NNP cord-023095-4dannjjm 69 13 2.3 2.3 CD cord-023095-4dannjjm 69 14 mg/ mg/ NN cord-023095-4dannjjm 69 15 ml ml NNP cord-023095-4dannjjm 69 16 ) ) -RRB- cord-023095-4dannjjm 69 17 than than IN cord-023095-4dannjjm 69 18 dogs dog NNS cord-023095-4dannjjm 69 19 with with IN cord-023095-4dannjjm 69 20 CHF CHF NNP cord-023095-4dannjjm 69 21 ( ( -LRB- cord-023095-4dannjjm 69 22 17.9 17.9 CD cord-023095-4dannjjm 69 23 AE AE NNP cord-023095-4dannjjm 69 24 17.1 17.1 CD cord-023095-4dannjjm 69 25 mg mg NNP cord-023095-4dannjjm 69 26 / / SYM cord-023095-4dannjjm 69 27 ml ml NNP cord-023095-4dannjjm 69 28 ) ) -RRB- cord-023095-4dannjjm 69 29 , , , cord-023095-4dannjjm 69 30 however however RB cord-023095-4dannjjm 69 31 , , , cord-023095-4dannjjm 69 32 the the DT cord-023095-4dannjjm 69 33 results result NNS cord-023095-4dannjjm 69 34 were be VBD cord-023095-4dannjjm 69 35 not not RB cord-023095-4dannjjm 69 36 statistically statistically RB cord-023095-4dannjjm 69 37 significant significant JJ cord-023095-4dannjjm 69 38 due due IN cord-023095-4dannjjm 69 39 to to IN cord-023095-4dannjjm 69 40 the the DT cord-023095-4dannjjm 69 41 large large JJ cord-023095-4dannjjm 69 42 variability variability NN cord-023095-4dannjjm 69 43 seen see VBN cord-023095-4dannjjm 69 44 among among IN cord-023095-4dannjjm 69 45 the the DT cord-023095-4dannjjm 69 46 CHF CHF NNP cord-023095-4dannjjm 69 47 dogs dog NNS cord-023095-4dannjjm 69 48 ( ( -LRB- cord-023095-4dannjjm 69 49 p p NN cord-023095-4dannjjm 69 50 5 5 CD cord-023095-4dannjjm 69 51 0.07 0.07 CD cord-023095-4dannjjm 69 52 ) ) -RRB- cord-023095-4dannjjm 69 53 . . . cord-023095-4dannjjm 70 1 We -PRON- PRP cord-023095-4dannjjm 70 2 found find VBD cord-023095-4dannjjm 70 3 greater great JJR cord-023095-4dannjjm 70 4 mean mean VB cord-023095-4dannjjm 70 5 ADPN ADPN NNP cord-023095-4dannjjm 70 6 concentrations concentration NNS cord-023095-4dannjjm 70 7 in in IN cord-023095-4dannjjm 70 8 normal normal JJ cord-023095-4dannjjm 70 9 dogs dog NNS cord-023095-4dannjjm 70 10 ( ( -LRB- cord-023095-4dannjjm 70 11 11.46 11.46 CD cord-023095-4dannjjm 70 12 AE AE NNP cord-023095-4dannjjm 70 13 3.3 3.3 CD cord-023095-4dannjjm 70 14 mg mg NNP cord-023095-4dannjjm 70 15 / / SYM cord-023095-4dannjjm 70 16 ml ml NNP cord-023095-4dannjjm 70 17 ) ) -RRB- cord-023095-4dannjjm 70 18 than than IN cord-023095-4dannjjm 70 19 CHF CHF NNP cord-023095-4dannjjm 70 20 dogs dog NNS cord-023095-4dannjjm 70 21 ( ( -LRB- cord-023095-4dannjjm 70 22 9.2 9.2 CD cord-023095-4dannjjm 70 23 AE AE NNP cord-023095-4dannjjm 70 24 3.2 3.2 CD cord-023095-4dannjjm 70 25 mg mg NNP cord-023095-4dannjjm 70 26 / / SYM cord-023095-4dannjjm 70 27 ml ml NN cord-023095-4dannjjm 70 28 ) ) -RRB- cord-023095-4dannjjm 71 1 ( ( -LRB- cord-023095-4dannjjm 71 2 p p NN cord-023095-4dannjjm 71 3 5 5 CD cord-023095-4dannjjm 71 4 0.05 0.05 CD cord-023095-4dannjjm 71 5 ) ) -RRB- cord-023095-4dannjjm 71 6 . . . cord-023095-4dannjjm 72 1 In in IN cord-023095-4dannjjm 72 2 general general JJ cord-023095-4dannjjm 72 3 , , , cord-023095-4dannjjm 72 4 the the DT cord-023095-4dannjjm 72 5 greater great JJR cord-023095-4dannjjm 72 6 the the DT cord-023095-4dannjjm 72 7 severity severity NN cord-023095-4dannjjm 72 8 of of IN cord-023095-4dannjjm 72 9 the the DT cord-023095-4dannjjm 72 10 heart heart NN cord-023095-4dannjjm 72 11 failure failure NN cord-023095-4dannjjm 72 12 , , , cord-023095-4dannjjm 72 13 the the DT cord-023095-4dannjjm 72 14 lower low JJR cord-023095-4dannjjm 72 15 the the DT cord-023095-4dannjjm 72 16 level level NN cord-023095-4dannjjm 72 17 of of IN cord-023095-4dannjjm 72 18 serum serum NN cord-023095-4dannjjm 72 19 ADPN ADPN NNP cord-023095-4dannjjm 72 20 . . . cord-023095-4dannjjm 73 1 When when WRB cord-023095-4dannjjm 73 2 the the DT cord-023095-4dannjjm 73 3 2 2 CD cord-023095-4dannjjm 73 4 tests test NNS cord-023095-4dannjjm 73 5 The the DT cord-023095-4dannjjm 73 6 purpose purpose NN cord-023095-4dannjjm 73 7 of of IN cord-023095-4dannjjm 73 8 this this DT cord-023095-4dannjjm 73 9 study study NN cord-023095-4dannjjm 73 10 was be VBD cord-023095-4dannjjm 73 11 to to TO cord-023095-4dannjjm 73 12 determine determine VB cord-023095-4dannjjm 73 13 if if IN cord-023095-4dannjjm 73 14 there there EX cord-023095-4dannjjm 73 15 are be VBP cord-023095-4dannjjm 73 16 any any DT cord-023095-4dannjjm 73 17 clinically clinically RB cord-023095-4dannjjm 73 18 important important JJ cord-023095-4dannjjm 73 19 differences difference NNS cord-023095-4dannjjm 73 20 between between IN cord-023095-4dannjjm 73 21 the the DT cord-023095-4dannjjm 73 22 approaches approach NNS cord-023095-4dannjjm 73 23 ( ( -LRB- cord-023095-4dannjjm 73 24 including include VBG cord-023095-4dannjjm 73 25 devices device NNS cord-023095-4dannjjm 73 26 ) ) -RRB- cord-023095-4dannjjm 73 27 used use VBN cord-023095-4dannjjm 73 28 in in IN cord-023095-4dannjjm 73 29 non non JJ cord-023095-4dannjjm 73 30 invasive invasive JJ cord-023095-4dannjjm 73 31 transvascular transvascular JJ cord-023095-4dannjjm 73 32 ( ( -LRB- cord-023095-4dannjjm 73 33 interventional interventional JJ cord-023095-4dannjjm 73 34 ) ) -RRB- cord-023095-4dannjjm 73 35 closure closure NN cord-023095-4dannjjm 73 36 of of IN cord-023095-4dannjjm 73 37 patent patent NN cord-023095-4dannjjm 73 38 ductus ductus NN cord-023095-4dannjjm 73 39 arteriosus arteriosus NN cord-023095-4dannjjm 73 40 ( ( -LRB- cord-023095-4dannjjm 73 41 PDA PDA NNP cord-023095-4dannjjm 73 42 ) ) -RRB- cord-023095-4dannjjm 73 43 in in IN cord-023095-4dannjjm 73 44 dogs dog NNS cord-023095-4dannjjm 73 45 in in IN cord-023095-4dannjjm 73 46 our -PRON- PRP$ cord-023095-4dannjjm 73 47 institution institution NN cord-023095-4dannjjm 73 48 . . . cord-023095-4dannjjm 74 1 Initial initial JJ cord-023095-4dannjjm 74 2 and and CC cord-023095-4dannjjm 74 3 follow follow VB cord-023095-4dannjjm 74 4 up up RP cord-023095-4dannjjm 74 5 records record NNS cord-023095-4dannjjm 74 6 from from IN cord-023095-4dannjjm 74 7 all all DT cord-023095-4dannjjm 74 8 dogs dog NNS cord-023095-4dannjjm 74 9 ( ( -LRB- cord-023095-4dannjjm 74 10 n n NN cord-023095-4dannjjm 74 11 5 5 CD cord-023095-4dannjjm 74 12 112 112 CD cord-023095-4dannjjm 74 13 ) ) -RRB- cord-023095-4dannjjm 74 14 that that WDT cord-023095-4dannjjm 74 15 underwent undergo VBD cord-023095-4dannjjm 74 16 attempted attempt VBN cord-023095-4dannjjm 74 17 transvascular transvascular JJ cord-023095-4dannjjm 74 18 PDA pda NN cord-023095-4dannjjm 74 19 occlusion occlusion NN cord-023095-4dannjjm 74 20 from from IN cord-023095-4dannjjm 74 21 January January NNP cord-023095-4dannjjm 74 22 2006-December 2006-december CD cord-023095-4dannjjm 74 23 2009 2009 CD cord-023095-4dannjjm 74 24 were be VBD cord-023095-4dannjjm 74 25 examined examine VBN cord-023095-4dannjjm 74 26 . . . cord-023095-4dannjjm 75 1 Dogs dog NNS cord-023095-4dannjjm 75 2 were be VBD cord-023095-4dannjjm 75 3 placed place VBN cord-023095-4dannjjm 75 4 into into IN cord-023095-4dannjjm 75 5 4 4 CD cord-023095-4dannjjm 75 6 groups group NNS cord-023095-4dannjjm 75 7 depending depend VBG cord-023095-4dannjjm 75 8 on on IN cord-023095-4dannjjm 75 9 the the DT cord-023095-4dannjjm 75 10 device device NN cord-023095-4dannjjm 75 11 and and CC cord-023095-4dannjjm 75 12 route route NN cord-023095-4dannjjm 75 13 of of IN cord-023095-4dannjjm 75 14 vascular vascular JJ cord-023095-4dannjjm 75 15 access access NN cord-023095-4dannjjm 75 16 ( ( -LRB- cord-023095-4dannjjm 75 17 transvenous transvenous JJ cord-023095-4dannjjm 75 18 or or CC cord-023095-4dannjjm 75 19 transarterial transarterial NNP cord-023095-4dannjjm 75 20 ) ) -RRB- cord-023095-4dannjjm 75 21 . . . cord-023095-4dannjjm 76 1 Group group NN cord-023095-4dannjjm 76 2 1 1 CD cord-023095-4dannjjm 76 3 : : : cord-023095-4dannjjm 77 1 Amplatz Amplatz NNP cord-023095-4dannjjm 77 2 s s POS cord-023095-4dannjjm 77 3 Canine Canine NNP cord-023095-4dannjjm 77 4 Ductal Ductal NNP cord-023095-4dannjjm 77 5 Occluder Occluder NNP cord-023095-4dannjjm 77 6 ( ( -LRB- cord-023095-4dannjjm 77 7 ACDO ACDO NNP cord-023095-4dannjjm 77 8 ) ) -RRB- cord-023095-4dannjjm 78 1 ( ( -LRB- cord-023095-4dannjjm 78 2 transarterial transarterial JJ cord-023095-4dannjjm 78 3 ) ) -RRB- cord-023095-4dannjjm 79 1 -36 -36 XX cord-023095-4dannjjm 80 1 dogs dog NNS cord-023095-4dannjjm 80 2 ; ; : cord-023095-4dannjjm 80 3 Group group NN cord-023095-4dannjjm 80 4 2 2 CD cord-023095-4dannjjm 80 5 : : : cord-023095-4dannjjm 80 6 Gianturco Gianturco NNP cord-023095-4dannjjm 80 7 s s POS cord-023095-4dannjjm 80 8 or or CC cord-023095-4dannjjm 80 9 MReye MReye NNP cord-023095-4dannjjm 80 10 Flipper Flipper NNP cord-023095-4dannjjm 80 11 s s POS cord-023095-4dannjjm 80 12 Detachable detachable JJ cord-023095-4dannjjm 80 13 Embolization Embolization NNP cord-023095-4dannjjm 80 14 ( ( -LRB- cord-023095-4dannjjm 80 15 Flipper flipper NN cord-023095-4dannjjm 80 16 ) ) -RRB- cord-023095-4dannjjm 80 17 coil coil NN cord-023095-4dannjjm 80 18 ( ( -LRB- cord-023095-4dannjjm 80 19 transarterial transarterial JJ cord-023095-4dannjjm 80 20 ) ) -RRB- cord-023095-4dannjjm 80 21 -38 -38 JJ cord-023095-4dannjjm 80 22 dogs dog NNS cord-023095-4dannjjm 80 23 ; ; : cord-023095-4dannjjm 80 24 Group group NN cord-023095-4dannjjm 80 25 3 3 CD cord-023095-4dannjjm 80 26 : : : cord-023095-4dannjjm 81 1 Amplatzer Amplatzer NNP cord-023095-4dannjjm 81 2 s s NNP cord-023095-4dannjjm 82 1 Vascular vascular JJ cord-023095-4dannjjm 82 2 Plug Plug NNP cord-023095-4dannjjm 82 3 ( ( -LRB- cord-023095-4dannjjm 82 4 AVP AVP NNP cord-023095-4dannjjm 82 5 ) ) -RRB- cord-023095-4dannjjm 82 6 ( ( -LRB- cord-023095-4dannjjm 82 7 transarterial transarterial JJ cord-023095-4dannjjm 82 8 ) ) -RRB- cord-023095-4dannjjm 83 1 -23 -23 . cord-023095-4dannjjm 84 1 dogs dog NNS cord-023095-4dannjjm 84 2 ; ; : cord-023095-4dannjjm 84 3 Group group NN cord-023095-4dannjjm 84 4 4 4 CD cord-023095-4dannjjm 84 5 : : : cord-023095-4dannjjm 84 6 Flipper flipper NN cord-023095-4dannjjm 84 7 coil coil NN cord-023095-4dannjjm 84 8 ( ( -LRB- cord-023095-4dannjjm 84 9 transvenous transvenous NNP cord-023095-4dannjjm 84 10 ) ) -RRB- cord-023095-4dannjjm 84 11 -15 -15 CD cord-023095-4dannjjm 84 12 dogs dog NNS cord-023095-4dannjjm 84 13 . . . cord-023095-4dannjjm 85 1 Statistical statistical JJ cord-023095-4dannjjm 85 2 comparisons comparison NNS cord-023095-4dannjjm 85 3 were be VBD cord-023095-4dannjjm 85 4 made make VBN cord-023095-4dannjjm 85 5 using use VBG cord-023095-4dannjjm 85 6 the the DT cord-023095-4dannjjm 85 7 Kruskal Kruskal NNP cord-023095-4dannjjm 85 8 - - HYPH cord-023095-4dannjjm 85 9 Wallis Wallis NNP cord-023095-4dannjjm 85 10 test test NN cord-023095-4dannjjm 85 11 with with IN cord-023095-4dannjjm 85 12 Mann Mann NNP cord-023095-4dannjjm 85 13 - - HYPH cord-023095-4dannjjm 85 14 Whitney Whitney NNP cord-023095-4dannjjm 85 15 tests test VBZ cord-023095-4dannjjm 85 16 to to TO cord-023095-4dannjjm 85 17 compare compare VB cord-023095-4dannjjm 85 18 pairs pair NNS cord-023095-4dannjjm 85 19 of of IN cord-023095-4dannjjm 85 20 groups group NNS cord-023095-4dannjjm 85 21 when when WRB cord-023095-4dannjjm 85 22 significance significance NN cord-023095-4dannjjm 85 23 was be VBD cord-023095-4dannjjm 85 24 detected detect VBN cord-023095-4dannjjm 85 25 . . . cord-023095-4dannjjm 86 1 P p NN cord-023095-4dannjjm 86 2 o o NN cord-023095-4dannjjm 86 3 0.05 0.05 CD cord-023095-4dannjjm 86 4 was be VBD cord-023095-4dannjjm 86 5 considered consider VBN cord-023095-4dannjjm 86 6 significant significant JJ cord-023095-4dannjjm 86 7 . . . cord-023095-4dannjjm 87 1 There there EX cord-023095-4dannjjm 87 2 was be VBD cord-023095-4dannjjm 87 3 no no DT cord-023095-4dannjjm 87 4 significant significant JJ cord-023095-4dannjjm 87 5 difference difference NN cord-023095-4dannjjm 87 6 in in IN cord-023095-4dannjjm 87 7 ages age NNS cord-023095-4dannjjm 87 8 between between IN cord-023095-4dannjjm 87 9 the the DT cord-023095-4dannjjm 87 10 4 4 CD cord-023095-4dannjjm 87 11 groups group NNS cord-023095-4dannjjm 87 12 . . . cord-023095-4dannjjm 88 1 There there EX cord-023095-4dannjjm 88 2 was be VBD cord-023095-4dannjjm 88 3 a a DT cord-023095-4dannjjm 88 4 significant significant JJ cord-023095-4dannjjm 88 5 difference difference NN cord-023095-4dannjjm 88 6 in in IN cord-023095-4dannjjm 88 7 body body NN cord-023095-4dannjjm 88 8 weight weight NN cord-023095-4dannjjm 88 9 between between IN cord-023095-4dannjjm 88 10 groups group NNS cord-023095-4dannjjm 88 11 with with IN cord-023095-4dannjjm 88 12 dogs dog NNS cord-023095-4dannjjm 88 13 receiving receive VBG cord-023095-4dannjjm 88 14 a a DT cord-023095-4dannjjm 88 15 coil coil NN cord-023095-4dannjjm 88 16 either either CC cord-023095-4dannjjm 88 17 transarterially transarterially RB cord-023095-4dannjjm 88 18 or or CC cord-023095-4dannjjm 88 19 transvenously transvenously RB cord-023095-4dannjjm 89 1 ( ( -LRB- cord-023095-4dannjjm 89 2 groups group NNS cord-023095-4dannjjm 89 3 2 2 CD cord-023095-4dannjjm 89 4 and and CC cord-023095-4dannjjm 89 5 4 4 LS cord-023095-4dannjjm 89 6 ) ) -RRB- cord-023095-4dannjjm 89 7 being be VBG cord-023095-4dannjjm 89 8 significantly significantly RB cord-023095-4dannjjm 89 9 smaller small JJR cord-023095-4dannjjm 89 10 than than IN cord-023095-4dannjjm 89 11 dogs dog NNS cord-023095-4dannjjm 89 12 receiving receive VBG cord-023095-4dannjjm 89 13 an an DT cord-023095-4dannjjm 89 14 ACDO ACDO NNP cord-023095-4dannjjm 89 15 or or CC cord-023095-4dannjjm 89 16 AVP AVP NNP cord-023095-4dannjjm 89 17 . . . cord-023095-4dannjjm 90 1 This this DT cord-023095-4dannjjm 90 2 was be VBD cord-023095-4dannjjm 90 3 by by IN cord-023095-4dannjjm 90 4 design design NN cord-023095-4dannjjm 90 5 since since IN cord-023095-4dannjjm 90 6 the the DT cord-023095-4dannjjm 90 7 ACDO ACDO NNP cord-023095-4dannjjm 90 8 and and CC cord-023095-4dannjjm 90 9 AVP AVP NNP cord-023095-4dannjjm 90 10 can can MD cord-023095-4dannjjm 90 11 not not RB cord-023095-4dannjjm 90 12 be be VB cord-023095-4dannjjm 90 13 used use VBN cord-023095-4dannjjm 90 14 in in IN cord-023095-4dannjjm 90 15 small small JJ cord-023095-4dannjjm 90 16 dogs dog NNS cord-023095-4dannjjm 90 17 . . . cord-023095-4dannjjm 91 1 Overall overall RB cord-023095-4dannjjm 91 2 , , , cord-023095-4dannjjm 91 3 the the DT cord-023095-4dannjjm 91 4 success success NN cord-023095-4dannjjm 91 5 rate rate NN cord-023095-4dannjjm 91 6 of of IN cord-023095-4dannjjm 91 7 the the DT cord-023095-4dannjjm 91 8 total total JJ cord-023095-4dannjjm 91 9 procedure procedure NN cord-023095-4dannjjm 91 10 ( ( -LRB- cord-023095-4dannjjm 91 11 including include VBG cord-023095-4dannjjm 91 12 vascular vascular JJ cord-023095-4dannjjm 91 13 access access NN cord-023095-4dannjjm 91 14 and and CC cord-023095-4dannjjm 91 15 satisfactory satisfactory JJ cord-023095-4dannjjm 91 16 PDA pda NN cord-023095-4dannjjm 91 17 occlusion occlusion NN cord-023095-4dannjjm 91 18 ) ) -RRB- cord-023095-4dannjjm 91 19 was be VBD cord-023095-4dannjjm 91 20 high high JJ cord-023095-4dannjjm 91 21 ( ( -LRB- cord-023095-4dannjjm 91 22 92 92 CD cord-023095-4dannjjm 91 23 % % NN cord-023095-4dannjjm 91 24 ) ) -RRB- cord-023095-4dannjjm 91 25 with with IN cord-023095-4dannjjm 91 26 success success NN cord-023095-4dannjjm 91 27 rates rate NNS cord-023095-4dannjjm 91 28 being be VBG cord-023095-4dannjjm 91 29 comparable comparable JJ cord-023095-4dannjjm 91 30 between between IN cord-023095-4dannjjm 91 31 groups group NNS cord-023095-4dannjjm 91 32 ( ( -LRB- cord-023095-4dannjjm 91 33 87 87 CD cord-023095-4dannjjm 91 34 - - SYM cord-023095-4dannjjm 91 35 97 97 CD cord-023095-4dannjjm 91 36 % % NN cord-023095-4dannjjm 91 37 ) ) -RRB- cord-023095-4dannjjm 91 38 . . . cord-023095-4dannjjm 92 1 There there EX cord-023095-4dannjjm 92 2 was be VBD cord-023095-4dannjjm 92 3 a a DT cord-023095-4dannjjm 92 4 significant significant JJ cord-023095-4dannjjm 92 5 difference difference NN cord-023095-4dannjjm 92 6 in in IN cord-023095-4dannjjm 92 7 complication complication NN cord-023095-4dannjjm 92 8 rate rate NN cord-023095-4dannjjm 92 9 between between IN cord-023095-4dannjjm 92 10 groups group NNS cord-023095-4dannjjm 92 11 ( ( -LRB- cord-023095-4dannjjm 92 12 p p NN cord-023095-4dannjjm 92 13 o o NN cord-023095-4dannjjm 92 14 0.0001 0.0001 CD cord-023095-4dannjjm 92 15 ) ) -RRB- cord-023095-4dannjjm 92 16 with with IN cord-023095-4dannjjm 92 17 the the DT cord-023095-4dannjjm 92 18 ACDO ACDO NNP cord-023095-4dannjjm 92 19 group group NN cord-023095-4dannjjm 92 20 having have VBG cord-023095-4dannjjm 92 21 a a DT cord-023095-4dannjjm 92 22 markedly markedly RB cord-023095-4dannjjm 92 23 lower low JJR cord-023095-4dannjjm 92 24 complication complication NN cord-023095-4dannjjm 92 25 rate rate NN cord-023095-4dannjjm 92 26 than than IN cord-023095-4dannjjm 92 27 the the DT cord-023095-4dannjjm 92 28 remaining remain VBG cord-023095-4dannjjm 92 29 groups group NNS cord-023095-4dannjjm 92 30 ( ( -LRB- cord-023095-4dannjjm 92 31 3 3 CD cord-023095-4dannjjm 92 32 % % NN cord-023095-4dannjjm 92 33 for for IN cord-023095-4dannjjm 92 34 ACDO ACDO NNP cord-023095-4dannjjm 92 35 versus versus IN cord-023095-4dannjjm 92 36 24 24 CD cord-023095-4dannjjm 92 37 - - SYM cord-023095-4dannjjm 92 38 33 33 CD cord-023095-4dannjjm 92 39 % % NN cord-023095-4dannjjm 92 40 for for IN cord-023095-4dannjjm 92 41 the the DT cord-023095-4dannjjm 92 42 other other JJ cord-023095-4dannjjm 92 43 groups group NNS cord-023095-4dannjjm 92 44 ) ) -RRB- cord-023095-4dannjjm 92 45 . . . cord-023095-4dannjjm 93 1 Total total JJ cord-023095-4dannjjm 93 2 fluoroscopy fluoroscopy JJ cord-023095-4dannjjm 93 3 time time NN cord-023095-4dannjjm 93 4 ranged range VBD cord-023095-4dannjjm 93 5 from from IN cord-023095-4dannjjm 93 6 3 3 CD cord-023095-4dannjjm 93 7 - - SYM cord-023095-4dannjjm 93 8 78 78 CD cord-023095-4dannjjm 93 9 minutes minute NNS cord-023095-4dannjjm 93 10 ( ( -LRB- cord-023095-4dannjjm 93 11 median median JJ cord-023095-4dannjjm 93 12 8 8 CD cord-023095-4dannjjm 93 13 minutes minute NNS cord-023095-4dannjjm 93 14 ) ) -RRB- cord-023095-4dannjjm 93 15 . . . cord-023095-4dannjjm 94 1 Fluoroscopy fluoroscopy JJ cord-023095-4dannjjm 94 2 time time NN cord-023095-4dannjjm 94 3 for for IN cord-023095-4dannjjm 94 4 the the DT cord-023095-4dannjjm 94 5 transvenous transvenous JJ cord-023095-4dannjjm 94 6 method method NN cord-023095-4dannjjm 94 7 was be VBD cord-023095-4dannjjm 94 8 significantly significantly RB cord-023095-4dannjjm 94 9 longer long JJR cord-023095-4dannjjm 94 10 ( ( -LRB- cord-023095-4dannjjm 94 11 median median JJ cord-023095-4dannjjm 94 12 13 13 CD cord-023095-4dannjjm 94 13 minutes minute NNS cord-023095-4dannjjm 94 14 ; ; : cord-023095-4dannjjm 94 15 range range VBP cord-023095-4dannjjm 94 16 10 10 CD cord-023095-4dannjjm 94 17 - - SYM cord-023095-4dannjjm 94 18 78 78 CD cord-023095-4dannjjm 94 19 minutes minute NNS cord-023095-4dannjjm 94 20 ) ) -RRB- cord-023095-4dannjjm 94 21 than than IN cord-023095-4dannjjm 94 22 in in IN cord-023095-4dannjjm 94 23 the the DT cord-023095-4dannjjm 94 24 remaining remain VBG cord-023095-4dannjjm 94 25 groups group NNS cord-023095-4dannjjm 94 26 ( ( -LRB- cord-023095-4dannjjm 94 27 median median JJ cord-023095-4dannjjm 94 28 6 6 CD cord-023095-4dannjjm 94 29 minutes minute NNS cord-023095-4dannjjm 94 30 ; ; : cord-023095-4dannjjm 94 31 range range VBP cord-023095-4dannjjm 94 32 3 3 CD cord-023095-4dannjjm 94 33 - - SYM cord-023095-4dannjjm 94 34 33 33 CD cord-023095-4dannjjm 94 35 minutes minute NNS cord-023095-4dannjjm 94 36 ) ) -RRB- cord-023095-4dannjjm 94 37 ( ( -LRB- cord-023095-4dannjjm 94 38 p p NN cord-023095-4dannjjm 94 39 o o NN cord-023095-4dannjjm 94 40 0.0001 0.0001 CD cord-023095-4dannjjm 94 41 ) ) -RRB- cord-023095-4dannjjm 94 42 . . . cord-023095-4dannjjm 95 1 Number number NN cord-023095-4dannjjm 95 2 of of IN cord-023095-4dannjjm 95 3 dogs dog NNS cord-023095-4dannjjm 95 4 with with IN cord-023095-4dannjjm 95 5 residual residual JJ cord-023095-4dannjjm 95 6 flow flow NN cord-023095-4dannjjm 95 7 immediately immediately RB cord-023095-4dannjjm 95 8 following follow VBG cord-023095-4dannjjm 95 9 the the DT cord-023095-4dannjjm 95 10 procedure procedure NN cord-023095-4dannjjm 95 11 and and CC cord-023095-4dannjjm 95 12 24 24 CD cord-023095-4dannjjm 95 13 hrs hrs NN cord-023095-4dannjjm 95 14 later later RB cord-023095-4dannjjm 95 15 was be VBD cord-023095-4dannjjm 95 16 significantly significantly RB cord-023095-4dannjjm 95 17 less less JJR cord-023095-4dannjjm 95 18 in in IN cord-023095-4dannjjm 95 19 the the DT cord-023095-4dannjjm 95 20 ACDO ACDO NNP cord-023095-4dannjjm 95 21 group group NN cord-023095-4dannjjm 95 22 than than IN cord-023095-4dannjjm 95 23 in in IN cord-023095-4dannjjm 95 24 the the DT cord-023095-4dannjjm 95 25 remaining remain VBG cord-023095-4dannjjm 95 26 groups group NNS cord-023095-4dannjjm 95 27 ( ( -LRB- cord-023095-4dannjjm 95 28 2 2 CD cord-023095-4dannjjm 95 29 dogs dog NNS cord-023095-4dannjjm 95 30 from from IN cord-023095-4dannjjm 95 31 group group NN cord-023095-4dannjjm 95 32 2 2 CD cord-023095-4dannjjm 95 33 and and CC cord-023095-4dannjjm 95 34 3 3 CD cord-023095-4dannjjm 95 35 from from IN cord-023095-4dannjjm 95 36 group group NN cord-023095-4dannjjm 95 37 3 3 CD cord-023095-4dannjjm 95 38 had have VBD cord-023095-4dannjjm 95 39 moderate moderate JJ cord-023095-4dannjjm 95 40 persistent persistent JJ cord-023095-4dannjjm 95 41 flow flow NN cord-023095-4dannjjm 95 42 while while IN cord-023095-4dannjjm 95 43 1 1 CD cord-023095-4dannjjm 95 44 dog dog NN cord-023095-4dannjjm 95 45 from from IN cord-023095-4dannjjm 95 46 group group NN cord-023095-4dannjjm 95 47 2 2 CD cord-023095-4dannjjm 95 48 and and CC cord-023095-4dannjjm 95 49 1 1 CD cord-023095-4dannjjm 95 50 from from IN cord-023095-4dannjjm 95 51 group group NN cord-023095-4dannjjm 95 52 4 4 CD cord-023095-4dannjjm 95 53 had have VBD cord-023095-4dannjjm 95 54 severe severe JJ cord-023095-4dannjjm 95 55 persistent persistent JJ cord-023095-4dannjjm 95 56 flow flow NN cord-023095-4dannjjm 95 57 24 24 CD cord-023095-4dannjjm 95 58 hours hour NNS cord-023095-4dannjjm 95 59 after after IN cord-023095-4dannjjm 95 60 the the DT cord-023095-4dannjjm 95 61 procedure procedure NN cord-023095-4dannjjm 95 62 ) ) -RRB- cord-023095-4dannjjm 95 63 . . . cord-023095-4dannjjm 96 1 The the DT cord-023095-4dannjjm 96 2 ACDO ACDO NNP cord-023095-4dannjjm 96 3 appears appear VBZ cord-023095-4dannjjm 96 4 superior superior JJ cord-023095-4dannjjm 96 5 in in IN cord-023095-4dannjjm 96 6 ease ease NN cord-023095-4dannjjm 96 7 of of IN cord-023095-4dannjjm 96 8 use use NN cord-023095-4dannjjm 96 9 , , , cord-023095-4dannjjm 96 10 complication complication NN cord-023095-4dannjjm 96 11 rate rate NN cord-023095-4dannjjm 96 12 , , , cord-023095-4dannjjm 96 13 completeness completeness NN cord-023095-4dannjjm 96 14 of of IN cord-023095-4dannjjm 96 15 occlusion occlusion NN cord-023095-4dannjjm 96 16 and and CC cord-023095-4dannjjm 96 17 fluoroscopy fluoroscopy JJ cord-023095-4dannjjm 96 18 time time NN cord-023095-4dannjjm 96 19 than than IN cord-023095-4dannjjm 96 20 other other JJ cord-023095-4dannjjm 96 21 devices device NNS cord-023095-4dannjjm 96 22 . . . cord-023095-4dannjjm 97 1 The the DT cord-023095-4dannjjm 97 2 remaining remain VBG cord-023095-4dannjjm 97 3 limiting limit VBG cord-023095-4dannjjm 97 4 factor factor NN cord-023095-4dannjjm 97 5 with with IN cord-023095-4dannjjm 97 6 this this DT cord-023095-4dannjjm 97 7 device device NN cord-023095-4dannjjm 97 8 is be VBZ cord-023095-4dannjjm 97 9 patient patient JJ cord-023095-4dannjjm 97 10 size size NN cord-023095-4dannjjm 97 11 . . . cord-023095-4dannjjm 98 1 Until until IN cord-023095-4dannjjm 98 2 a a DT cord-023095-4dannjjm 98 3 smaller small JJR cord-023095-4dannjjm 98 4 ACDO ACDO NNP cord-023095-4dannjjm 98 5 device device NN cord-023095-4dannjjm 98 6 is be VBZ cord-023095-4dannjjm 98 7 marketed market VBN cord-023095-4dannjjm 98 8 , , , cord-023095-4dannjjm 98 9 coils coil NNS cord-023095-4dannjjm 98 10 remain remain VBP cord-023095-4dannjjm 98 11 the the DT cord-023095-4dannjjm 98 12 only only JJ cord-023095-4dannjjm 98 13 choice choice NN cord-023095-4dannjjm 98 14 for for IN cord-023095-4dannjjm 98 15 interventional interventional JJ cord-023095-4dannjjm 98 16 closure closure NN cord-023095-4dannjjm 98 17 in in IN cord-023095-4dannjjm 98 18 very very RB cord-023095-4dannjjm 98 19 small small JJ cord-023095-4dannjjm 98 20 dogs dog NNS cord-023095-4dannjjm 98 21 ( ( -LRB- cord-023095-4dannjjm 98 22 o o NN cord-023095-4dannjjm 98 23 2.5 2.5 CD cord-023095-4dannjjm 98 24 kg kg NNS cord-023095-4dannjjm 98 25 ) ) -RRB- cord-023095-4dannjjm 98 26 . . . cord-023095-4dannjjm 99 1 Previously previously RB cord-023095-4dannjjm 99 2 presented present VBN cord-023095-4dannjjm 99 3 at at IN cord-023095-4dannjjm 99 4 the the DT cord-023095-4dannjjm 99 5 University University NNP cord-023095-4dannjjm 99 6 of of IN cord-023095-4dannjjm 99 7 California California NNP cord-023095-4dannjjm 99 8 Davis Davis NNP cord-023095-4dannjjm 99 9 , , , cord-023095-4dannjjm 99 10 House House NNP cord-023095-4dannjjm 99 11 Officers Officers NNPS cord-023095-4dannjjm 99 12 Seminar Seminar NNP cord-023095-4dannjjm 99 13 Day Day NNP cord-023095-4dannjjm 99 14 . . . cord-023095-4dannjjm 100 1 Subvalvular subvalvular JJ cord-023095-4dannjjm 100 2 aortic aortic JJ cord-023095-4dannjjm 100 3 stenosis stenosis NN cord-023095-4dannjjm 101 1 ( ( -LRB- cord-023095-4dannjjm 101 2 SAS SAS NNP cord-023095-4dannjjm 101 3 ) ) -RRB- cord-023095-4dannjjm 101 4 is be VBZ cord-023095-4dannjjm 101 5 one one CD cord-023095-4dannjjm 101 6 of of IN cord-023095-4dannjjm 101 7 the the DT cord-023095-4dannjjm 101 8 most most RBS cord-023095-4dannjjm 101 9 commonly commonly RB cord-023095-4dannjjm 101 10 reported report VBN cord-023095-4dannjjm 101 11 canine canine JJ cord-023095-4dannjjm 101 12 congenital congenital JJ cord-023095-4dannjjm 101 13 heart heart NN cord-023095-4dannjjm 101 14 defects defect NNS cord-023095-4dannjjm 101 15 and and CC cord-023095-4dannjjm 101 16 is be VBZ cord-023095-4dannjjm 101 17 inherited inherit VBN cord-023095-4dannjjm 101 18 in in IN cord-023095-4dannjjm 101 19 Newfoundland Newfoundland NNP cord-023095-4dannjjm 101 20 dogs dog NNS cord-023095-4dannjjm 101 21 and and CC cord-023095-4dannjjm 101 22 human human JJ cord-023095-4dannjjm 101 23 beings being NNS cord-023095-4dannjjm 101 24 . . . cord-023095-4dannjjm 102 1 The the DT cord-023095-4dannjjm 102 2 golden golden JJ cord-023095-4dannjjm 102 3 retriever retriever NN cord-023095-4dannjjm 102 4 and and CC cord-023095-4dannjjm 102 5 Rottweiler Rottweiler NNP cord-023095-4dannjjm 102 6 are be VBP cord-023095-4dannjjm 102 7 breeds breed NNS cord-023095-4dannjjm 102 8 over over RB cord-023095-4dannjjm 102 9 - - HYPH cord-023095-4dannjjm 102 10 represented represent VBN cord-023095-4dannjjm 102 11 in in IN cord-023095-4dannjjm 102 12 dogs dog NNS cord-023095-4dannjjm 102 13 with with IN cord-023095-4dannjjm 102 14 subvalvular subvalvular JJ cord-023095-4dannjjm 102 15 aortic aortic JJ cord-023095-4dannjjm 102 16 stenosis stenosis NN cord-023095-4dannjjm 102 17 ; ; : cord-023095-4dannjjm 102 18 however however RB cord-023095-4dannjjm 102 19 , , , cord-023095-4dannjjm 102 20 a a DT cord-023095-4dannjjm 102 21 genetic genetic JJ cord-023095-4dannjjm 102 22 cause cause NN cord-023095-4dannjjm 102 23 of of IN cord-023095-4dannjjm 102 24 this this DT cord-023095-4dannjjm 102 25 disease disease NN cord-023095-4dannjjm 102 26 in in IN cord-023095-4dannjjm 102 27 these these DT cord-023095-4dannjjm 102 28 breeds breed NNS cord-023095-4dannjjm 102 29 has have VBZ cord-023095-4dannjjm 102 30 not not RB cord-023095-4dannjjm 102 31 been be VBN cord-023095-4dannjjm 102 32 described describe VBN cord-023095-4dannjjm 102 33 . . . cord-023095-4dannjjm 103 1 We -PRON- PRP cord-023095-4dannjjm 103 2 performed perform VBD cord-023095-4dannjjm 103 3 genome genome NN cord-023095-4dannjjm 103 4 wide wide NNP cord-023095-4dannjjm 103 5 association association NN cord-023095-4dannjjm 103 6 analysis analysis NN cord-023095-4dannjjm 103 7 in in IN cord-023095-4dannjjm 103 8 both both CC cord-023095-4dannjjm 103 9 normal normal JJ cord-023095-4dannjjm 103 10 and and CC cord-023095-4dannjjm 103 11 SAS SAS NNP cord-023095-4dannjjm 103 12 affected affect VBD cord-023095-4dannjjm 103 13 Rottweilers Rottweilers NNPS cord-023095-4dannjjm 103 14 and and CC cord-023095-4dannjjm 103 15 golden golden JJ cord-023095-4dannjjm 103 16 retrievers retriever NNS cord-023095-4dannjjm 103 17 to to TO cord-023095-4dannjjm 103 18 identify identify VB cord-023095-4dannjjm 103 19 chromosomal chromosomal JJ cord-023095-4dannjjm 103 20 regions region NNS cord-023095-4dannjjm 103 21 of of IN cord-023095-4dannjjm 103 22 interest interest NN cord-023095-4dannjjm 103 23 that that WDT cord-023095-4dannjjm 103 24 could could MD cord-023095-4dannjjm 103 25 implicate implicate VB cord-023095-4dannjjm 103 26 a a DT cord-023095-4dannjjm 103 27 causative causative JJ cord-023095-4dannjjm 103 28 mutation mutation NN cord-023095-4dannjjm 103 29 by by IN cord-023095-4dannjjm 103 30 high high JJ cord-023095-4dannjjm 103 31 density density NN cord-023095-4dannjjm 103 32 single single JJ cord-023095-4dannjjm 103 33 nucleotide nucleotide JJ cord-023095-4dannjjm 103 34 polymorphism polymorphism NN cord-023095-4dannjjm 103 35 ( ( -LRB- cord-023095-4dannjjm 103 36 SNP SNP NNP cord-023095-4dannjjm 103 37 ) ) -RRB- cord-023095-4dannjjm 103 38 array array NN cord-023095-4dannjjm 103 39 . . . cord-023095-4dannjjm 104 1 48 48 CD cord-023095-4dannjjm 105 1 ( ( -LRB- cord-023095-4dannjjm 105 2 24 24 CD cord-023095-4dannjjm 105 3 unaffected/24 unaffected/24 NNP cord-023095-4dannjjm 105 4 affected affected JJ cord-023095-4dannjjm 105 5 ) ) -RRB- cord-023095-4dannjjm 105 6 adult adult NN cord-023095-4dannjjm 105 7 golden golden JJ cord-023095-4dannjjm 105 8 retrievers retriever NNS cord-023095-4dannjjm 105 9 and and CC cord-023095-4dannjjm 105 10 48 48 CD cord-023095-4dannjjm 105 11 ( ( -LRB- cord-023095-4dannjjm 105 12 20 20 CD cord-023095-4dannjjm 105 13 unaffected/28 unaffected/28 JJ cord-023095-4dannjjm 105 14 affected affected JJ cord-023095-4dannjjm 105 15 ) ) -RRB- cord-023095-4dannjjm 105 16 adult adult NN cord-023095-4dannjjm 105 17 Rottweilers rottweiler NNS cord-023095-4dannjjm 105 18 were be VBD cord-023095-4dannjjm 105 19 included include VBN cord-023095-4dannjjm 105 20 in in IN cord-023095-4dannjjm 105 21 this this DT cord-023095-4dannjjm 105 22 study study NN cord-023095-4dannjjm 105 23 . . . cord-023095-4dannjjm 106 1 Criteria criterion NNS cord-023095-4dannjjm 106 2 for for IN cord-023095-4dannjjm 106 3 affected affect VBN cord-023095-4dannjjm 106 4 included include VBD cord-023095-4dannjjm 106 5 a a DT cord-023095-4dannjjm 106 6 subcostal subcostal JJ cord-023095-4dannjjm 106 7 continuous continuous JJ cord-023095-4dannjjm 106 8 - - HYPH cord-023095-4dannjjm 106 9 wave wave NN cord-023095-4dannjjm 106 10 Doppler Doppler NNP cord-023095-4dannjjm 106 11 aortic aortic JJ cord-023095-4dannjjm 106 12 velocity velocity NN cord-023095-4dannjjm 106 13 ! ! . cord-023095-4dannjjm 107 1 2.5 2.5 CD cord-023095-4dannjjm 107 2 m m NN cord-023095-4dannjjm 107 3 / / SYM cord-023095-4dannjjm 107 4 s s NN cord-023095-4dannjjm 107 5 and and CC cord-023095-4dannjjm 107 6 presence presence NN cord-023095-4dannjjm 107 7 of of IN cord-023095-4dannjjm 107 8 a a DT cord-023095-4dannjjm 107 9 left left JJ cord-023095-4dannjjm 107 10 basilar basilar JJ cord-023095-4dannjjm 107 11 systolic systolic JJ cord-023095-4dannjjm 107 12 ejection ejection NN cord-023095-4dannjjm 107 13 murmur murmur NN cord-023095-4dannjjm 108 1 ; ; : cord-023095-4dannjjm 108 2 criteria criterion NNS cord-023095-4dannjjm 108 3 for for IN cord-023095-4dannjjm 108 4 unaffected unaffected JJ cord-023095-4dannjjm 108 5 included include VBD cord-023095-4dannjjm 108 6 a a DT cord-023095-4dannjjm 108 7 Doppler Doppler NNP cord-023095-4dannjjm 108 8 aortic aortic JJ cord-023095-4dannjjm 108 9 velocity velocity NN cord-023095-4dannjjm 108 10 1.8 1.8 CD cord-023095-4dannjjm 108 11 m m NN cord-023095-4dannjjm 108 12 / / SYM cord-023095-4dannjjm 108 13 s s NN cord-023095-4dannjjm 108 14 . . . cord-023095-4dannjjm 109 1 DNA dna NN cord-023095-4dannjjm 109 2 samples sample NNS cord-023095-4dannjjm 109 3 were be VBD cord-023095-4dannjjm 109 4 obtained obtain VBN cord-023095-4dannjjm 109 5 from from IN cord-023095-4dannjjm 109 6 anticoagulated anticoagulated JJ cord-023095-4dannjjm 109 7 blood blood NN cord-023095-4dannjjm 109 8 . . . cord-023095-4dannjjm 110 1 Genotypes genotype NNS cord-023095-4dannjjm 110 2 were be VBD cord-023095-4dannjjm 110 3 obtained obtain VBN cord-023095-4dannjjm 110 4 using use VBG cord-023095-4dannjjm 110 5 high high JJ cord-023095-4dannjjm 110 6 density density NN cord-023095-4dannjjm 110 7 ( ( -LRB- cord-023095-4dannjjm 110 8 173,662 173,662 CD cord-023095-4dannjjm 110 9 ) ) -RRB- cord-023095-4dannjjm 110 10 SNP SNP NNP cord-023095-4dannjjm 110 11 arrays array NNS cord-023095-4dannjjm 110 12 , , , cord-023095-4dannjjm 110 13 and and CC cord-023095-4dannjjm 110 14 genome genome NNP cord-023095-4dannjjm 110 15 wide wide JJ cord-023095-4dannjjm 110 16 association association NN cord-023095-4dannjjm 110 17 with with IN cord-023095-4dannjjm 110 18 SAS SAS NNP cord-023095-4dannjjm 110 19 was be VBD cord-023095-4dannjjm 110 20 evaluated evaluate VBN cord-023095-4dannjjm 110 21 for for IN cord-023095-4dannjjm 110 22 each each DT cord-023095-4dannjjm 110 23 breed breed NN cord-023095-4dannjjm 110 24 . . . cord-023095-4dannjjm 111 1 Significance significance NN cord-023095-4dannjjm 111 2 cut cut NN cord-023095-4dannjjm 111 3 - - HYPH cord-023095-4dannjjm 111 4 off off NN cord-023095-4dannjjm 111 5 was be VBD cord-023095-4dannjjm 111 6 set set VBN cord-023095-4dannjjm 111 7 at at IN cord-023095-4dannjjm 111 8 p p NN cord-023095-4dannjjm 111 9 5 5 CD cord-023095-4dannjjm 111 10 5 5 CD cord-023095-4dannjjm 111 11 Â â CD cord-023095-4dannjjm 111 12 10 10 CD cord-023095-4dannjjm 111 13 À5 À5 NNP cord-023095-4dannjjm 111 14 , , , cord-023095-4dannjjm 111 15 and and CC cord-023095-4dannjjm 111 16 all all DT cord-023095-4dannjjm 111 17 SNPs SNPs NNPS cord-023095-4dannjjm 111 18 meeting meet VBG cord-023095-4dannjjm 111 19 this this DT cord-023095-4dannjjm 111 20 criterion criterion NN cord-023095-4dannjjm 111 21 were be VBD cord-023095-4dannjjm 111 22 plotted plot VBN cord-023095-4dannjjm 111 23 within within IN cord-023095-4dannjjm 111 24 each each DT cord-023095-4dannjjm 111 25 breed breed NN cord-023095-4dannjjm 111 26 and and CC cord-023095-4dannjjm 111 27 compared compare VBN cord-023095-4dannjjm 111 28 across across IN cord-023095-4dannjjm 111 29 breeds breed NNS cord-023095-4dannjjm 111 30 using use VBG cord-023095-4dannjjm 111 31 PLINK PLINK NNP cord-023095-4dannjjm 111 32 . . . cord-023095-4dannjjm 112 1 Affected affected JJ cord-023095-4dannjjm 112 2 golden golden JJ cord-023095-4dannjjm 112 3 retriever retriever NN cord-023095-4dannjjm 112 4 data datum NNS cord-023095-4dannjjm 112 5 implicate implicate VBP cord-023095-4dannjjm 112 6 the the DT cord-023095-4dannjjm 112 7 most most RBS cord-023095-4dannjjm 112 8 significant significant JJ cord-023095-4dannjjm 112 9 region region NN cord-023095-4dannjjm 112 10 of of IN cord-023095-4dannjjm 112 11 genetic genetic JJ cord-023095-4dannjjm 112 12 variation variation NN cord-023095-4dannjjm 112 13 on on IN cord-023095-4dannjjm 112 14 chromosome chromosome NN cord-023095-4dannjjm 112 15 21 21 CD cord-023095-4dannjjm 112 16 at at IN cord-023095-4dannjjm 112 17 location location NN cord-023095-4dannjjm 112 18 27384260 27384260 CD cord-023095-4dannjjm 113 1 ( ( -LRB- cord-023095-4dannjjm 113 2 p p NN cord-023095-4dannjjm 113 3 5 5 CD cord-023095-4dannjjm 113 4 1.15 1.15 CD cord-023095-4dannjjm 113 5 Â â CD cord-023095-4dannjjm 113 6 10 10 CD cord-023095-4dannjjm 113 7 À5 À5 NNP cord-023095-4dannjjm 113 8 ; ; : cord-023095-4dannjjm 113 9 odds odd NNS cord-023095-4dannjjm 113 10 ratio ratio NN cord-023095-4dannjjm 113 11 7.58 7.58 CD cord-023095-4dannjjm 113 12 ) ) -RRB- cord-023095-4dannjjm 113 13 with with IN cord-023095-4dannjjm 113 14 11 11 CD cord-023095-4dannjjm 113 15 other other JJ cord-023095-4dannjjm 113 16 significant significant JJ cord-023095-4dannjjm 113 17 surrounding surround VBG cord-023095-4dannjjm 113 18 SNPs snp NNS cord-023095-4dannjjm 113 19 . . . cord-023095-4dannjjm 114 1 Affected affected JJ cord-023095-4dannjjm 114 2 Rottweiler Rottweiler NNP cord-023095-4dannjjm 114 3 data datum NNS cord-023095-4dannjjm 114 4 also also RB cord-023095-4dannjjm 114 5 implicate implicate VBP cord-023095-4dannjjm 114 6 the the DT cord-023095-4dannjjm 114 7 most most RBS cord-023095-4dannjjm 114 8 significant significant JJ cord-023095-4dannjjm 114 9 region region NN cord-023095-4dannjjm 114 10 of of IN cord-023095-4dannjjm 114 11 genetic genetic JJ cord-023095-4dannjjm 114 12 variation variation NN cord-023095-4dannjjm 114 13 on on IN cord-023095-4dannjjm 114 14 chromosome chromosome NN cord-023095-4dannjjm 114 15 21 21 CD cord-023095-4dannjjm 114 16 at at IN cord-023095-4dannjjm 114 17 location location NN cord-023095-4dannjjm 114 18 27895300 27895300 CD cord-023095-4dannjjm 115 1 ( ( -LRB- cord-023095-4dannjjm 115 2 p p NN cord-023095-4dannjjm 115 3 5 5 CD cord-023095-4dannjjm 115 4 8.98 8.98 CD cord-023095-4dannjjm 115 5 Â â CD cord-023095-4dannjjm 115 6 10 10 CD cord-023095-4dannjjm 115 7 À6 à6 NN cord-023095-4dannjjm 115 8 ; ; : cord-023095-4dannjjm 115 9 odds odd NNS cord-023095-4dannjjm 115 10 ratio ratio NN cord-023095-4dannjjm 115 11 23.39 23.39 CD cord-023095-4dannjjm 115 12 ) ) -RRB- cord-023095-4dannjjm 115 13 with with IN cord-023095-4dannjjm 115 14 3 3 CD cord-023095-4dannjjm 115 15 other other JJ cord-023095-4dannjjm 115 16 significant significant JJ cord-023095-4dannjjm 115 17 surrounding surround VBG cord-023095-4dannjjm 115 18 SNPs snp NNS cord-023095-4dannjjm 115 19 . . . cord-023095-4dannjjm 116 1 Other other JJ cord-023095-4dannjjm 116 2 regions region NNS cord-023095-4dannjjm 116 3 of of IN cord-023095-4dannjjm 116 4 statistical statistical JJ cord-023095-4dannjjm 116 5 significance significance NN cord-023095-4dannjjm 116 6 were be VBD cord-023095-4dannjjm 116 7 on on IN cord-023095-4dannjjm 116 8 chromosomes chromosome NNS cord-023095-4dannjjm 116 9 4 4 CD cord-023095-4dannjjm 116 10 and and CC cord-023095-4dannjjm 116 11 7 7 CD cord-023095-4dannjjm 116 12 in in IN cord-023095-4dannjjm 116 13 the the DT cord-023095-4dannjjm 116 14 golden golden JJ cord-023095-4dannjjm 116 15 retriever retriever NN cord-023095-4dannjjm 116 16 and and CC cord-023095-4dannjjm 116 17 11 11 CD cord-023095-4dannjjm 116 18 and and CC cord-023095-4dannjjm 116 19 38 38 CD cord-023095-4dannjjm 116 20 in in IN cord-023095-4dannjjm 116 21 the the DT cord-023095-4dannjjm 116 22 Rottweiler Rottweiler NNP cord-023095-4dannjjm 116 23 . . . cord-023095-4dannjjm 117 1 Genome Genome NNP cord-023095-4dannjjm 117 2 wide wide JJ cord-023095-4dannjjm 117 3 association association NN cord-023095-4dannjjm 117 4 with with IN cord-023095-4dannjjm 117 5 subvalvular subvalvular JJ cord-023095-4dannjjm 117 6 aortic aortic JJ cord-023095-4dannjjm 117 7 stenosis stenosis NN cord-023095-4dannjjm 117 8 in in IN cord-023095-4dannjjm 117 9 the the DT cord-023095-4dannjjm 117 10 golden golden JJ cord-023095-4dannjjm 117 11 retriever retriever NN cord-023095-4dannjjm 117 12 and and CC cord-023095-4dannjjm 117 13 Rottweiler Rottweiler NNP cord-023095-4dannjjm 117 14 implicate implicate VBP cord-023095-4dannjjm 117 15 overlapping overlap VBG cord-023095-4dannjjm 117 16 chromosomal chromosomal JJ cord-023095-4dannjjm 117 17 regions region NNS cord-023095-4dannjjm 117 18 of of IN cord-023095-4dannjjm 117 19 interest interest NN cord-023095-4dannjjm 117 20 for for IN cord-023095-4dannjjm 117 21 causative causative JJ cord-023095-4dannjjm 117 22 mutations mutation NNS cord-023095-4dannjjm 117 23 on on IN cord-023095-4dannjjm 117 24 chromosome chromosome NN cord-023095-4dannjjm 117 25 21 21 CD cord-023095-4dannjjm 117 26 . . . cord-023095-4dannjjm 118 1 The the DT cord-023095-4dannjjm 118 2 different different JJ cord-023095-4dannjjm 118 3 secondary secondary JJ cord-023095-4dannjjm 118 4 chromosomal chromosomal JJ cord-023095-4dannjjm 118 5 regions region NNS cord-023095-4dannjjm 118 6 of of IN cord-023095-4dannjjm 118 7 interest interest NN cord-023095-4dannjjm 118 8 ( ( -LRB- cord-023095-4dannjjm 118 9 CHR CHR NNP cord-023095-4dannjjm 118 10 4 4 CD cord-023095-4dannjjm 118 11 , , , cord-023095-4dannjjm 118 12 7 7 CD cord-023095-4dannjjm 118 13 in in IN cord-023095-4dannjjm 118 14 golden golden JJ cord-023095-4dannjjm 118 15 retrievers retriever NNS cord-023095-4dannjjm 118 16 and and CC cord-023095-4dannjjm 118 17 11 11 CD cord-023095-4dannjjm 118 18 , , , cord-023095-4dannjjm 118 19 38 38 CD cord-023095-4dannjjm 118 20 in in IN cord-023095-4dannjjm 118 21 Rottweilers Rottweilers NNPS cord-023095-4dannjjm 118 22 ) ) -RRB- cord-023095-4dannjjm 118 23 supports support VBZ cord-023095-4dannjjm 118 24 the the DT cord-023095-4dannjjm 118 25 known know VBN cord-023095-4dannjjm 118 26 familial familial JJ cord-023095-4dannjjm 118 27 nature nature NN cord-023095-4dannjjm 118 28 of of IN cord-023095-4dannjjm 118 29 this this DT cord-023095-4dannjjm 118 30 disease disease NN cord-023095-4dannjjm 118 31 within within IN cord-023095-4dannjjm 118 32 different different JJ cord-023095-4dannjjm 118 33 breeds breed NNS cord-023095-4dannjjm 118 34 and and CC cord-023095-4dannjjm 118 35 may may MD cord-023095-4dannjjm 118 36 suggest suggest VB cord-023095-4dannjjm 118 37 the the DT cord-023095-4dannjjm 118 38 presence presence NN cord-023095-4dannjjm 118 39 of of IN cord-023095-4dannjjm 118 40 multiple multiple JJ cord-023095-4dannjjm 118 41 mutations mutation NNS cord-023095-4dannjjm 118 42 or or CC cord-023095-4dannjjm 118 43 breed breed VB cord-023095-4dannjjm 118 44 specific specific JJ cord-023095-4dannjjm 118 45 disease disease NN cord-023095-4dannjjm 118 46 modifiers modifier NNS cord-023095-4dannjjm 118 47 . . . cord-023095-4dannjjm 119 1 These these DT cord-023095-4dannjjm 119 2 data datum NNS cord-023095-4dannjjm 119 3 highlight highlight VBP cord-023095-4dannjjm 119 4 the the DT cord-023095-4dannjjm 119 5 need need NN cord-023095-4dannjjm 119 6 for for IN cord-023095-4dannjjm 119 7 candidate candidate NN cord-023095-4dannjjm 119 8 gene gene NN cord-023095-4dannjjm 119 9 evaluation evaluation NN cord-023095-4dannjjm 119 10 on on IN cord-023095-4dannjjm 119 11 chromosome chromosome NN cord-023095-4dannjjm 119 12 21 21 CD cord-023095-4dannjjm 119 13 in in IN cord-023095-4dannjjm 119 14 golden golden JJ cord-023095-4dannjjm 119 15 retrievers retriever NNS cord-023095-4dannjjm 119 16 and and CC cord-023095-4dannjjm 119 17 Rottweilers Rottweilers NNPS cord-023095-4dannjjm 119 18 with with IN cord-023095-4dannjjm 119 19 SAS SAS NNP cord-023095-4dannjjm 119 20 . . . cord-023095-4dannjjm 120 1 Heart heart NN cord-023095-4dannjjm 120 2 valves valve NNS cord-023095-4dannjjm 120 3 share share VBP cord-023095-4dannjjm 120 4 developmental developmental JJ cord-023095-4dannjjm 120 5 signaling signal VBG cord-023095-4dannjjm 120 6 pathways pathway NNS cord-023095-4dannjjm 120 7 with with IN cord-023095-4dannjjm 120 8 bone bone NN cord-023095-4dannjjm 120 9 and and CC cord-023095-4dannjjm 120 10 cartilage cartilage NN cord-023095-4dannjjm 120 11 . . . cord-023095-4dannjjm 121 1 Degenerative degenerative JJ cord-023095-4dannjjm 121 2 aortic aortic JJ cord-023095-4dannjjm 121 3 valve valve NN cord-023095-4dannjjm 121 4 disease disease NN cord-023095-4dannjjm 121 5 in in IN cord-023095-4dannjjm 121 6 humans human NNS cord-023095-4dannjjm 121 7 is be VBZ cord-023095-4dannjjm 121 8 characterized characterize VBN cord-023095-4dannjjm 121 9 by by IN cord-023095-4dannjjm 121 10 valve valve NN cord-023095-4dannjjm 121 11 stenosis stenosis NN cord-023095-4dannjjm 121 12 and and CC cord-023095-4dannjjm 121 13 calcification calcification NN cord-023095-4dannjjm 121 14 . . . cord-023095-4dannjjm 122 1 Recent recent JJ cord-023095-4dannjjm 122 2 evidence evidence NN cord-023095-4dannjjm 122 3 suggests suggest VBZ cord-023095-4dannjjm 122 4 that that IN cord-023095-4dannjjm 122 5 degenerative degenerative JJ cord-023095-4dannjjm 122 6 aortic aortic JJ cord-023095-4dannjjm 122 7 valves valve NNS cord-023095-4dannjjm 122 8 are be VBP cord-023095-4dannjjm 122 9 undergoing undergo VBG cord-023095-4dannjjm 122 10 pathologic pathologic JJ cord-023095-4dannjjm 122 11 processes process NNS cord-023095-4dannjjm 122 12 that that WDT cord-023095-4dannjjm 122 13 mimic mimic VBP cord-023095-4dannjjm 122 14 osteogenesis osteogenesis NN cord-023095-4dannjjm 122 15 . . . cord-023095-4dannjjm 123 1 Degenerative degenerative JJ cord-023095-4dannjjm 123 2 mitral mitral JJ cord-023095-4dannjjm 123 3 valves valve NNS cord-023095-4dannjjm 123 4 in in IN cord-023095-4dannjjm 123 5 dogs dog NNS cord-023095-4dannjjm 123 6 and and CC cord-023095-4dannjjm 123 7 humans human NNS cord-023095-4dannjjm 123 8 are be VBP cord-023095-4dannjjm 123 9 characterized characterize VBN cord-023095-4dannjjm 123 10 by by IN cord-023095-4dannjjm 123 11 valve valve NN cord-023095-4dannjjm 123 12 regurgitation regurgitation NN cord-023095-4dannjjm 123 13 , , , cord-023095-4dannjjm 123 14 and and CC cord-023095-4dannjjm 123 15 rarely rarely RB cord-023095-4dannjjm 123 16 undergo undergo VB cord-023095-4dannjjm 123 17 calcification calcification NN cord-023095-4dannjjm 123 18 . . . cord-023095-4dannjjm 124 1 We -PRON- PRP cord-023095-4dannjjm 124 2 tested test VBD cord-023095-4dannjjm 124 3 the the DT cord-023095-4dannjjm 124 4 hypothesis hypothesis NN cord-023095-4dannjjm 124 5 that that IN cord-023095-4dannjjm 124 6 canine canine JJ cord-023095-4dannjjm 124 7 and and CC cord-023095-4dannjjm 124 8 human human JJ cord-023095-4dannjjm 124 9 degenerative degenerative JJ cord-023095-4dannjjm 124 10 mitral mitral JJ cord-023095-4dannjjm 124 11 valves valve NNS cord-023095-4dannjjm 124 12 might may MD cord-023095-4dannjjm 124 13 be be VB cord-023095-4dannjjm 124 14 undergoing undergo VBG cord-023095-4dannjjm 124 15 pathologic pathologic JJ cord-023095-4dannjjm 124 16 processes process NNS cord-023095-4dannjjm 124 17 that that WDT cord-023095-4dannjjm 124 18 mimic mimic VBP cord-023095-4dannjjm 124 19 chondrogenesis chondrogenesis NN cord-023095-4dannjjm 124 20 . . . cord-023095-4dannjjm 125 1 To to TO cord-023095-4dannjjm 125 2 test test VB cord-023095-4dannjjm 125 3 this this DT cord-023095-4dannjjm 125 4 hypothesis hypothesis NN cord-023095-4dannjjm 125 5 , , , cord-023095-4dannjjm 125 6 expression expression NN cord-023095-4dannjjm 125 7 of of IN cord-023095-4dannjjm 125 8 bone bone NN cord-023095-4dannjjm 125 9 morphogenic morphogenic JJ cord-023095-4dannjjm 125 10 protein protein NN cord-023095-4dannjjm 125 11 2 2 CD cord-023095-4dannjjm 125 12 ( ( -LRB- cord-023095-4dannjjm 125 13 BMP2 BMP2 NNP cord-023095-4dannjjm 125 14 ) ) -RRB- cord-023095-4dannjjm 125 15 , , , cord-023095-4dannjjm 125 16 a a DT cord-023095-4dannjjm 125 17 chondrogenic chondrogenic JJ cord-023095-4dannjjm 125 18 growth growth NN cord-023095-4dannjjm 125 19 factor factor NN cord-023095-4dannjjm 125 20 ; ; : cord-023095-4dannjjm 125 21 Sox Sox NNP cord-023095-4dannjjm 125 22 9 9 CD cord-023095-4dannjjm 125 23 , , , cord-023095-4dannjjm 125 24 a a DT cord-023095-4dannjjm 125 25 chondrogenic chondrogenic NN cord-023095-4dannjjm 125 26 transcription transcription NN cord-023095-4dannjjm 125 27 factor factor NN cord-023095-4dannjjm 125 28 ; ; : cord-023095-4dannjjm 125 29 aggrecan aggrecan NNP cord-023095-4dannjjm 125 30 , , , cord-023095-4dannjjm 125 31 a a DT cord-023095-4dannjjm 125 32 proteoglycan proteoglycan NN cord-023095-4dannjjm 125 33 abundant abundant JJ cord-023095-4dannjjm 125 34 in in IN cord-023095-4dannjjm 125 35 cartilage cartilage NN cord-023095-4dannjjm 125 36 ; ; : cord-023095-4dannjjm 125 37 and and CC cord-023095-4dannjjm 125 38 type type NN cord-023095-4dannjjm 125 39 II ii CD cord-023095-4dannjjm 125 40 collagen collagen NN cord-023095-4dannjjm 125 41 were be VBD cord-023095-4dannjjm 125 42 evaluated evaluate VBN cord-023095-4dannjjm 125 43 utilizing utilize VBG cord-023095-4dannjjm 125 44 immunohistochemistry immunohistochemistry NN cord-023095-4dannjjm 125 45 . . . cord-023095-4dannjjm 126 1 Normal normal JJ cord-023095-4dannjjm 126 2 canine canine JJ cord-023095-4dannjjm 126 3 mitral mitral JJ cord-023095-4dannjjm 126 4 valves valve NNS cord-023095-4dannjjm 126 5 , , , cord-023095-4dannjjm 126 6 different different JJ cord-023095-4dannjjm 126 7 stages stage NNS cord-023095-4dannjjm 126 8 of of IN cord-023095-4dannjjm 126 9 canine canine JJ cord-023095-4dannjjm 126 10 degenerative degenerative JJ cord-023095-4dannjjm 126 11 mitral mitral JJ cord-023095-4dannjjm 126 12 valves valve NNS cord-023095-4dannjjm 126 13 ( ( -LRB- cord-023095-4dannjjm 126 14 early early JJ cord-023095-4dannjjm 126 15 , , , cord-023095-4dannjjm 126 16 intermediate intermediate JJ cord-023095-4dannjjm 126 17 , , , cord-023095-4dannjjm 126 18 and and CC cord-023095-4dannjjm 126 19 late late RB cord-023095-4dannjjm 126 20 ) ) -RRB- cord-023095-4dannjjm 126 21 , , , cord-023095-4dannjjm 126 22 and and CC cord-023095-4dannjjm 126 23 late late JJ cord-023095-4dannjjm 126 24 - - HYPH cord-023095-4dannjjm 126 25 stage stage NN cord-023095-4dannjjm 126 26 human human JJ cord-023095-4dannjjm 126 27 degenerative degenerative JJ cord-023095-4dannjjm 126 28 mitral mitral JJ cord-023095-4dannjjm 126 29 valves valve NNS cord-023095-4dannjjm 126 30 were be VBD cord-023095-4dannjjm 126 31 studied study VBN cord-023095-4dannjjm 126 32 . . . cord-023095-4dannjjm 127 1 Canine canine JJ cord-023095-4dannjjm 127 2 and and CC cord-023095-4dannjjm 127 3 human human JJ cord-023095-4dannjjm 127 4 degenerative degenerative JJ cord-023095-4dannjjm 127 5 mitral mitral JJ cord-023095-4dannjjm 127 6 valves valve NNS cord-023095-4dannjjm 127 7 showed show VBD cord-023095-4dannjjm 127 8 focal focal JJ cord-023095-4dannjjm 127 9 areas area NNS cord-023095-4dannjjm 127 10 that that WDT cord-023095-4dannjjm 127 11 co co VBD cord-023095-4dannjjm 127 12 - - VBD cord-023095-4dannjjm 127 13 expressed express VBD cord-023095-4dannjjm 127 14 all all DT cord-023095-4dannjjm 127 15 four four CD cord-023095-4dannjjm 127 16 markers marker NNS cord-023095-4dannjjm 127 17 of of IN cord-023095-4dannjjm 127 18 chondrogenic chondrogenic NN cord-023095-4dannjjm 127 19 signaling signaling NN cord-023095-4dannjjm 127 20 and and CC cord-023095-4dannjjm 127 21 phenotype phenotype NN cord-023095-4dannjjm 127 22 . . . cord-023095-4dannjjm 128 1 Valve valve NN cord-023095-4dannjjm 128 2 interstitial interstitial JJ cord-023095-4dannjjm 128 3 cells cell NNS cord-023095-4dannjjm 128 4 and and CC cord-023095-4dannjjm 128 5 surrounding surround VBG cord-023095-4dannjjm 128 6 extracellular extracellular JJ cord-023095-4dannjjm 128 7 matrix matrix NN cord-023095-4dannjjm 128 8 in in IN cord-023095-4dannjjm 128 9 these these DT cord-023095-4dannjjm 128 10 focal focal JJ cord-023095-4dannjjm 128 11 areas area NNS cord-023095-4dannjjm 128 12 adopted adopt VBD cord-023095-4dannjjm 128 13 a a DT cord-023095-4dannjjm 128 14 morphologic morphologic JJ cord-023095-4dannjjm 128 15 appearance appearance NN cord-023095-4dannjjm 128 16 reminiscent reminiscent JJ cord-023095-4dannjjm 128 17 of of IN cord-023095-4dannjjm 128 18 cartilage cartilage NN cord-023095-4dannjjm 128 19 . . . cord-023095-4dannjjm 129 1 Focal focal JJ cord-023095-4dannjjm 129 2 chondrogenesis chondrogenesis NN cord-023095-4dannjjm 129 3 was be VBD cord-023095-4dannjjm 129 4 present present JJ cord-023095-4dannjjm 129 5 in in IN cord-023095-4dannjjm 129 6 all all DT cord-023095-4dannjjm 129 7 stages stage NNS cord-023095-4dannjjm 129 8 of of IN cord-023095-4dannjjm 129 9 canine canine JJ cord-023095-4dannjjm 129 10 degenerative degenerative JJ cord-023095-4dannjjm 129 11 mitral mitral JJ cord-023095-4dannjjm 129 12 valves valve NNS cord-023095-4dannjjm 129 13 , , , cord-023095-4dannjjm 129 14 but but CC cord-023095-4dannjjm 129 15 not not RB cord-023095-4dannjjm 129 16 normal normal JJ cord-023095-4dannjjm 129 17 canine canine JJ cord-023095-4dannjjm 129 18 mitral mitral JJ cord-023095-4dannjjm 129 19 valves valve NNS cord-023095-4dannjjm 129 20 . . . cord-023095-4dannjjm 130 1 Focal focal JJ cord-023095-4dannjjm 130 2 areas area NNS cord-023095-4dannjjm 130 3 of of IN cord-023095-4dannjjm 130 4 chondrogenesis chondrogenesis NNP cord-023095-4dannjjm 130 5 did do VBD cord-023095-4dannjjm 130 6 not not RB cord-023095-4dannjjm 130 7 coincide coincide VB cord-023095-4dannjjm 130 8 with with IN cord-023095-4dannjjm 130 9 nodular nodular JJ cord-023095-4dannjjm 130 10 areas area NNS cord-023095-4dannjjm 130 11 of of IN cord-023095-4dannjjm 130 12 glycosaminoglycan glycosaminoglycan JJ cord-023095-4dannjjm 130 13 accumulation accumulation NN cord-023095-4dannjjm 130 14 on on IN cord-023095-4dannjjm 130 15 the the DT cord-023095-4dannjjm 130 16 leaflet leaflet NN cord-023095-4dannjjm 130 17 edge edge NN cord-023095-4dannjjm 130 18 , , , cord-023095-4dannjjm 130 19 but but CC cord-023095-4dannjjm 130 20 rather rather RB cord-023095-4dannjjm 130 21 seemed seem VBD cord-023095-4dannjjm 130 22 to to TO cord-023095-4dannjjm 130 23 occur occur VB cord-023095-4dannjjm 130 24 at at IN cord-023095-4dannjjm 130 25 points point NNS cord-023095-4dannjjm 130 26 of of IN cord-023095-4dannjjm 130 27 chordae chordae NNP cord-023095-4dannjjm 130 28 attachment attachment NN cord-023095-4dannjjm 130 29 to to IN cord-023095-4dannjjm 130 30 leaflets leaflet NNS cord-023095-4dannjjm 130 31 . . . cord-023095-4dannjjm 131 1 In in IN cord-023095-4dannjjm 131 2 conclusion conclusion NN cord-023095-4dannjjm 131 3 , , , cord-023095-4dannjjm 131 4 canine canine JJ cord-023095-4dannjjm 131 5 and and CC cord-023095-4dannjjm 131 6 human human JJ cord-023095-4dannjjm 131 7 degenerative degenerative JJ cord-023095-4dannjjm 131 8 mitral mitral JJ cord-023095-4dannjjm 131 9 valves valve NNS cord-023095-4dannjjm 131 10 undergo undergo VBP cord-023095-4dannjjm 131 11 pathologic pathologic JJ cord-023095-4dannjjm 131 12 processes process NNS cord-023095-4dannjjm 131 13 that that WDT cord-023095-4dannjjm 131 14 mimic mimic VBP cord-023095-4dannjjm 131 15 chondrogenesis chondrogenesis NN cord-023095-4dannjjm 131 16 . . . cord-023095-4dannjjm 132 1 This this DT cord-023095-4dannjjm 132 2 finding finding NN cord-023095-4dannjjm 132 3 suggests suggest VBZ cord-023095-4dannjjm 132 4 that that IN cord-023095-4dannjjm 132 5 mitral mitral JJ cord-023095-4dannjjm 132 6 valve valve NN cord-023095-4dannjjm 132 7 degeneration degeneration NN cord-023095-4dannjjm 132 8 may may MD cord-023095-4dannjjm 132 9 be be VB cord-023095-4dannjjm 132 10 recapitulating recapitulate VBG cord-023095-4dannjjm 132 11 developmental developmental JJ cord-023095-4dannjjm 132 12 signaling signal VBG cord-023095-4dannjjm 132 13 pathways pathway NNS cord-023095-4dannjjm 132 14 shared share VBN cord-023095-4dannjjm 132 15 by by IN cord-023095-4dannjjm 132 16 heart heart NN cord-023095-4dannjjm 132 17 valves valve NNS cord-023095-4dannjjm 132 18 and and CC cord-023095-4dannjjm 132 19 cartilage cartilage NN cord-023095-4dannjjm 132 20 . . . cord-023095-4dannjjm 133 1 The the DT cord-023095-4dannjjm 133 2 triggering trigger VBG cord-023095-4dannjjm 133 3 events event NNS cord-023095-4dannjjm 133 4 for for IN cord-023095-4dannjjm 133 5 chondrogenesis chondrogenesis NNP cord-023095-4dannjjm 133 6 in in IN cord-023095-4dannjjm 133 7 mitral mitral JJ cord-023095-4dannjjm 133 8 valves valve NNS cord-023095-4dannjjm 133 9 remain remain VBP cord-023095-4dannjjm 133 10 unknown unknown JJ cord-023095-4dannjjm 133 11 ; ; : cord-023095-4dannjjm 133 12 as as IN cord-023095-4dannjjm 133 13 does do VBZ cord-023095-4dannjjm 133 14 the the DT cord-023095-4dannjjm 133 15 reason reason NN cord-023095-4dannjjm 133 16 why why WRB cord-023095-4dannjjm 133 17 aortic aortic JJ cord-023095-4dannjjm 133 18 and and CC cord-023095-4dannjjm 133 19 mitral mitral JJ cord-023095-4dannjjm 133 20 valves valve NNS cord-023095-4dannjjm 133 21 appear appear VBP cord-023095-4dannjjm 133 22 to to TO cord-023095-4dannjjm 133 23 be be VB cord-023095-4dannjjm 133 24 undergoing undergo VBG cord-023095-4dannjjm 133 25 different different JJ cord-023095-4dannjjm 133 26 pathologic pathologic JJ cord-023095-4dannjjm 133 27 processes process NNS cord-023095-4dannjjm 133 28 . . . cord-023095-4dannjjm 134 1 The the DT cord-023095-4dannjjm 134 2 fact fact NN cord-023095-4dannjjm 134 3 that that IN cord-023095-4dannjjm 134 4 humans human NNS cord-023095-4dannjjm 134 5 exhibit exhibit VBP cord-023095-4dannjjm 134 6 degeneration degeneration NN cord-023095-4dannjjm 134 7 of of IN cord-023095-4dannjjm 134 8 both both CC cord-023095-4dannjjm 134 9 the the DT cord-023095-4dannjjm 134 10 aortic aortic JJ cord-023095-4dannjjm 134 11 and and CC cord-023095-4dannjjm 134 12 mitral mitral JJ cord-023095-4dannjjm 134 13 valve valve NN cord-023095-4dannjjm 134 14 , , , cord-023095-4dannjjm 134 15 and and CC cord-023095-4dannjjm 134 16 that that IN cord-023095-4dannjjm 134 17 dogs dog NNS cord-023095-4dannjjm 134 18 commonly commonly RB cord-023095-4dannjjm 134 19 exhibit exhibit VBP cord-023095-4dannjjm 134 20 only only RB cord-023095-4dannjjm 134 21 the the DT cord-023095-4dannjjm 134 22 latter latter JJ cord-023095-4dannjjm 134 23 could could MD cord-023095-4dannjjm 134 24 eventually eventually RB cord-023095-4dannjjm 134 25 provide provide VB cord-023095-4dannjjm 134 26 insight insight NN cord-023095-4dannjjm 134 27 into into IN cord-023095-4dannjjm 134 28 both both DT cord-023095-4dannjjm 134 29 processes process NNS cord-023095-4dannjjm 134 30 . . . cord-023095-4dannjjm 135 1 Arrhythmogenic Arrhythmogenic NNP cord-023095-4dannjjm 135 2 right right JJ cord-023095-4dannjjm 135 3 ventricular ventricular JJ cord-023095-4dannjjm 135 4 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 135 5 ( ( -LRB- cord-023095-4dannjjm 135 6 ARVC ARVC NNP cord-023095-4dannjjm 135 7 ) ) -RRB- cord-023095-4dannjjm 135 8 is be VBZ cord-023095-4dannjjm 135 9 a a DT cord-023095-4dannjjm 135 10 familial familial JJ cord-023095-4dannjjm 135 11 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 135 12 characterized characterize VBN cord-023095-4dannjjm 135 13 by by IN cord-023095-4dannjjm 135 14 right right JJ cord-023095-4dannjjm 135 15 ventricular ventricular JJ cord-023095-4dannjjm 135 16 fibrofatty fibrofatty JJ cord-023095-4dannjjm 135 17 infiltration infiltration NN cord-023095-4dannjjm 135 18 and and CC cord-023095-4dannjjm 135 19 ventricular ventricular JJ cord-023095-4dannjjm 135 20 ectopy ectopy NN cord-023095-4dannjjm 135 21 of of IN cord-023095-4dannjjm 135 22 left left JJ cord-023095-4dannjjm 135 23 bundle bundle NN cord-023095-4dannjjm 135 24 branch branch NN cord-023095-4dannjjm 135 25 block block NN cord-023095-4dannjjm 135 26 morphology morphology NN cord-023095-4dannjjm 135 27 ( ( -LRB- cord-023095-4dannjjm 135 28 VPC VPC NNP cord-023095-4dannjjm 135 29 ) ) -RRB- cord-023095-4dannjjm 135 30 . . . cord-023095-4dannjjm 136 1 A a DT cord-023095-4dannjjm 136 2 deletion deletion NN cord-023095-4dannjjm 136 3 in in IN cord-023095-4dannjjm 136 4 the the DT cord-023095-4dannjjm 136 5 striatin striatin NN cord-023095-4dannjjm 136 6 gene gene NN cord-023095-4dannjjm 136 7 has have VBZ cord-023095-4dannjjm 136 8 been be VBN cord-023095-4dannjjm 136 9 associated associate VBN cord-023095-4dannjjm 136 10 with with IN cord-023095-4dannjjm 136 11 ARVC ARVC NNP cord-023095-4dannjjm 136 12 in in RP cord-023095-4dannjjm 136 13 at at IN cord-023095-4dannjjm 136 14 least least JJS cord-023095-4dannjjm 136 15 some some DT cord-023095-4dannjjm 136 16 boxer boxer NN cord-023095-4dannjjm 136 17 families family NNS cord-023095-4dannjjm 136 18 . . . cord-023095-4dannjjm 137 1 Syncope syncope NN cord-023095-4dannjjm 137 2 and and CC cord-023095-4dannjjm 137 3 sudden sudden JJ cord-023095-4dannjjm 137 4 death death NN cord-023095-4dannjjm 137 5 ( ( -LRB- cord-023095-4dannjjm 137 6 SD sd NN cord-023095-4dannjjm 137 7 ) ) -RRB- cord-023095-4dannjjm 137 8 occur occur VBP cord-023095-4dannjjm 137 9 in in IN cord-023095-4dannjjm 137 10 some some DT cord-023095-4dannjjm 137 11 affected affect VBN cord-023095-4dannjjm 137 12 dogs dog NNS cord-023095-4dannjjm 137 13 , , , cord-023095-4dannjjm 137 14 although although IN cord-023095-4dannjjm 137 15 many many JJ cord-023095-4dannjjm 137 16 affected affect VBN cord-023095-4dannjjm 137 17 dogs dog NNS cord-023095-4dannjjm 137 18 survive survive VBP cord-023095-4dannjjm 137 19 for for IN cord-023095-4dannjjm 137 20 years year NNS cord-023095-4dannjjm 137 21 . . . cord-023095-4dannjjm 138 1 The the DT cord-023095-4dannjjm 138 2 objective objective NN cord-023095-4dannjjm 138 3 of of IN cord-023095-4dannjjm 138 4 this this DT cord-023095-4dannjjm 138 5 study study NN cord-023095-4dannjjm 138 6 was be VBD cord-023095-4dannjjm 138 7 to to TO cord-023095-4dannjjm 138 8 define define VB cord-023095-4dannjjm 138 9 clinical clinical JJ cord-023095-4dannjjm 138 10 characteristics characteristic NNS cord-023095-4dannjjm 138 11 of of IN cord-023095-4dannjjm 138 12 ARVC ARVC NNP cord-023095-4dannjjm 138 13 in in IN cord-023095-4dannjjm 138 14 boxers boxer NNS cord-023095-4dannjjm 138 15 that that WDT cord-023095-4dannjjm 138 16 experienced experience VBD cord-023095-4dannjjm 138 17 SD sd NN cord-023095-4dannjjm 138 18 , , , cord-023095-4dannjjm 138 19 and and CC cord-023095-4dannjjm 138 20 compare compare VB cord-023095-4dannjjm 138 21 them -PRON- PRP cord-023095-4dannjjm 138 22 to to IN cord-023095-4dannjjm 138 23 those those DT cord-023095-4dannjjm 138 24 of of IN cord-023095-4dannjjm 138 25 a a DT cord-023095-4dannjjm 138 26 contemporaneous contemporaneous JJ cord-023095-4dannjjm 138 27 group group NN cord-023095-4dannjjm 138 28 of of IN cord-023095-4dannjjm 138 29 ARVC ARVC NNP cord-023095-4dannjjm 138 30 boxers boxer NNS cord-023095-4dannjjm 138 31 that that WDT cord-023095-4dannjjm 138 32 had have VBD cord-023095-4dannjjm 138 33 not not RB cord-023095-4dannjjm 138 34 died die VBN cord-023095-4dannjjm 138 35 suddenly suddenly RB cord-023095-4dannjjm 138 36 ( ( -LRB- cord-023095-4dannjjm 138 37 NSD NSD NNP cord-023095-4dannjjm 138 38 ) ) -RRB- cord-023095-4dannjjm 138 39 . . . cord-023095-4dannjjm 139 1 Data datum NNS cord-023095-4dannjjm 139 2 for for IN cord-023095-4dannjjm 139 3 both both DT cord-023095-4dannjjm 139 4 groups group NNS cord-023095-4dannjjm 139 5 were be VBD cord-023095-4dannjjm 139 6 collected collect VBN cord-023095-4dannjjm 139 7 from from IN cord-023095-4dannjjm 139 8 adult adult NN cord-023095-4dannjjm 139 9 boxers boxer NNS cord-023095-4dannjjm 139 10 enrolled enrol VBN cord-023095-4dannjjm 139 11 in in IN cord-023095-4dannjjm 139 12 a a DT cord-023095-4dannjjm 139 13 long long JJ cord-023095-4dannjjm 139 14 term term NN cord-023095-4dannjjm 139 15 prospective prospective JJ cord-023095-4dannjjm 139 16 study study NN cord-023095-4dannjjm 139 17 of of IN cord-023095-4dannjjm 139 18 ARVC ARVC NNP cord-023095-4dannjjm 139 19 in in IN cord-023095-4dannjjm 139 20 which which WDT cord-023095-4dannjjm 139 21 echocardiograms echocardiogram VBZ cord-023095-4dannjjm 139 22 and and CC cord-023095-4dannjjm 139 23 24 24 CD cord-023095-4dannjjm 139 24 hour hour NN cord-023095-4dannjjm 139 25 ambulatory ambulatory JJ cord-023095-4dannjjm 139 26 ECG ECG NNP cord-023095-4dannjjm 139 27 ( ( -LRB- cord-023095-4dannjjm 139 28 AECG AECG NNP cord-023095-4dannjjm 139 29 ) ) -RRB- cord-023095-4dannjjm 139 30 are be VBP cord-023095-4dannjjm 139 31 evaluated evaluate VBN cord-023095-4dannjjm 139 32 annually annually RB cord-023095-4dannjjm 139 33 . . . cord-023095-4dannjjm 140 1 AECG AECG NNP cord-023095-4dannjjm 140 2 are be VBP cord-023095-4dannjjm 140 3 quantitated quantitate VBN cord-023095-4dannjjm 140 4 for for IN cord-023095-4dannjjm 140 5 VPC VPC NNP cord-023095-4dannjjm 140 6 numbers number NNS cord-023095-4dannjjm 140 7 and and CC cord-023095-4dannjjm 140 8 arrhythmia arrhythmia NN cord-023095-4dannjjm 140 9 grade grade NN cord-023095-4dannjjm 140 10 ( ( -LRB- cord-023095-4dannjjm 140 11 1 1 CD cord-023095-4dannjjm 140 12 - - SYM cord-023095-4dannjjm 140 13 4 4 CD cord-023095-4dannjjm 140 14 ) ) -RRB- cord-023095-4dannjjm 140 15 . . . cord-023095-4dannjjm 141 1 ARVC ARVC NNP cord-023095-4dannjjm 141 2 diagnosis diagnosis NN cord-023095-4dannjjm 141 3 requires require VBZ cord-023095-4dannjjm 141 4 at at IN cord-023095-4dannjjm 141 5 least least JJS cord-023095-4dannjjm 141 6 100 100 CD cord-023095-4dannjjm 141 7 VPCs/ VPCs/ NNP cord-023095-4dannjjm 141 8 24 24 CD cord-023095-4dannjjm 141 9 hours hour NNS cord-023095-4dannjjm 141 10 in in IN cord-023095-4dannjjm 141 11 the the DT cord-023095-4dannjjm 141 12 absence absence NN cord-023095-4dannjjm 141 13 of of IN cord-023095-4dannjjm 141 14 other other JJ cord-023095-4dannjjm 141 15 disease disease NN cord-023095-4dannjjm 141 16 . . . cord-023095-4dannjjm 142 1 Forty forty CD cord-023095-4dannjjm 142 2 three three CD cord-023095-4dannjjm 142 3 adult adult NN cord-023095-4dannjjm 142 4 boxers boxer NNS cord-023095-4dannjjm 142 5 that that WDT cord-023095-4dannjjm 142 6 entered enter VBD cord-023095-4dannjjm 142 7 the the DT cord-023095-4dannjjm 142 8 study study NN cord-023095-4dannjjm 142 9 had have VBD cord-023095-4dannjjm 142 10 died die VBN cord-023095-4dannjjm 142 11 suddenly suddenly RB cord-023095-4dannjjm 142 12 at at IN cord-023095-4dannjjm 142 13 the the DT cord-023095-4dannjjm 142 14 time time NN cord-023095-4dannjjm 142 15 of of IN cord-023095-4dannjjm 142 16 analysis analysis NN cord-023095-4dannjjm 142 17 ( ( -LRB- cord-023095-4dannjjm 142 18 SD SD NNP cord-023095-4dannjjm 142 19 defined define VBN cord-023095-4dannjjm 142 20 as as IN cord-023095-4dannjjm 142 21 the the DT cord-023095-4dannjjm 142 22 absence absence NN cord-023095-4dannjjm 142 23 of of IN cord-023095-4dannjjm 142 24 observed observed JJ cord-023095-4dannjjm 142 25 clinical clinical JJ cord-023095-4dannjjm 142 26 signs sign NNS cord-023095-4dannjjm 142 27 within within IN cord-023095-4dannjjm 142 28 24 24 CD cord-023095-4dannjjm 142 29 hours hour NNS cord-023095-4dannjjm 142 30 prior prior RB cord-023095-4dannjjm 142 31 to to IN cord-023095-4dannjjm 142 32 an an DT cord-023095-4dannjjm 142 33 unexpected unexpected JJ cord-023095-4dannjjm 142 34 and and CC cord-023095-4dannjjm 142 35 unexplained unexplained JJ cord-023095-4dannjjm 142 36 death death NN cord-023095-4dannjjm 142 37 ) ) -RRB- cord-023095-4dannjjm 142 38 . . . cord-023095-4dannjjm 143 1 Striatin Striatin NNP cord-023095-4dannjjm 143 2 genotype genotype NN cord-023095-4dannjjm 143 3 was be VBD cord-023095-4dannjjm 143 4 available available JJ cord-023095-4dannjjm 143 5 for for IN cord-023095-4dannjjm 143 6 28 28 CD cord-023095-4dannjjm 143 7 of of IN cord-023095-4dannjjm 143 8 the the DT cord-023095-4dannjjm 143 9 43 43 CD cord-023095-4dannjjm 143 10 SD sd NN cord-023095-4dannjjm 143 11 dogs dog NNS cord-023095-4dannjjm 143 12 ( ( -LRB- cord-023095-4dannjjm 143 13 17 17 CD cord-023095-4dannjjm 143 14 heterozygotes heterozygote NNS cord-023095-4dannjjm 143 15 , , , cord-023095-4dannjjm 143 16 11 11 CD cord-023095-4dannjjm 143 17 homozygotes homozygote NNS cord-023095-4dannjjm 143 18 ) ) -RRB- cord-023095-4dannjjm 143 19 ; ; : cord-023095-4dannjjm 143 20 19 19 CD cord-023095-4dannjjm 143 21 were be VBD cord-023095-4dannjjm 143 22 female female JJ cord-023095-4dannjjm 143 23 ( ( -LRB- cord-023095-4dannjjm 143 24 9 9 CD cord-023095-4dannjjm 143 25 intact intact JJ cord-023095-4dannjjm 143 26 ) ) -RRB- cord-023095-4dannjjm 143 27 and and CC cord-023095-4dannjjm 143 28 24 24 CD cord-023095-4dannjjm 143 29 were be VBD cord-023095-4dannjjm 143 30 male male JJ cord-023095-4dannjjm 143 31 ( ( -LRB- cord-023095-4dannjjm 143 32 14 14 CD cord-023095-4dannjjm 143 33 intact intact JJ cord-023095-4dannjjm 143 34 ) ) -RRB- cord-023095-4dannjjm 143 35 . . . cord-023095-4dannjjm 144 1 SD SD NNP cord-023095-4dannjjm 144 2 occurred occur VBD cord-023095-4dannjjm 144 3 at at IN cord-023095-4dannjjm 144 4 a a DT cord-023095-4dannjjm 144 5 mean mean JJ cord-023095-4dannjjm 144 6 age age NN cord-023095-4dannjjm 144 7 of of IN cord-023095-4dannjjm 144 8 8 8 CD cord-023095-4dannjjm 144 9 years year NNS cord-023095-4dannjjm 145 1 ( ( -LRB- cord-023095-4dannjjm 145 2 range range NN cord-023095-4dannjjm 145 3 , , , cord-023095-4dannjjm 145 4 1 1 CD cord-023095-4dannjjm 145 5 - - SYM cord-023095-4dannjjm 145 6 12 12 CD cord-023095-4dannjjm 145 7 ) ) -RRB- cord-023095-4dannjjm 145 8 ; ; : cord-023095-4dannjjm 145 9 27 27 CD cord-023095-4dannjjm 145 10 SD sd NN cord-023095-4dannjjm 145 11 dogs dog NNS cord-023095-4dannjjm 145 12 ( ( -LRB- cord-023095-4dannjjm 145 13 63 63 CD cord-023095-4dannjjm 145 14 % % NN cord-023095-4dannjjm 145 15 ) ) -RRB- cord-023095-4dannjjm 145 16 had have VBD cord-023095-4dannjjm 145 17 no no DT cord-023095-4dannjjm 145 18 prior prior JJ cord-023095-4dannjjm 145 19 history history NN cord-023095-4dannjjm 145 20 of of IN cord-023095-4dannjjm 145 21 syncope syncope NN cord-023095-4dannjjm 145 22 . . . cord-023095-4dannjjm 146 1 Twelve twelve CD cord-023095-4dannjjm 146 2 SD sd NN cord-023095-4dannjjm 146 3 dogs dog NNS cord-023095-4dannjjm 146 4 ( ( -LRB- cord-023095-4dannjjm 146 5 28 28 CD cord-023095-4dannjjm 146 6 % % NN cord-023095-4dannjjm 146 7 ) ) -RRB- cord-023095-4dannjjm 146 8 were be VBD cord-023095-4dannjjm 146 9 on on IN cord-023095-4dannjjm 146 10 antiarrhythmics antiarrhythmic NNS cord-023095-4dannjjm 146 11 at at IN cord-023095-4dannjjm 146 12 the the DT cord-023095-4dannjjm 146 13 time time NN cord-023095-4dannjjm 146 14 of of IN cord-023095-4dannjjm 146 15 death death NN cord-023095-4dannjjm 146 16 ( ( -LRB- cord-023095-4dannjjm 146 17 metop metop NNP cord-023095-4dannjjm 146 18 - - HYPH cord-023095-4dannjjm 146 19 p0oooooooooooprolol p0oooooooooooprolol NNP cord-023095-4dannjjm 146 20 ( ( -LRB- cord-023095-4dannjjm 146 21 1 1 CD cord-023095-4dannjjm 146 22 ) ) -RRB- cord-023095-4dannjjm 146 23 , , , cord-023095-4dannjjm 146 24 sotalol sotalol NNP cord-023095-4dannjjm 146 25 ( ( -LRB- cord-023095-4dannjjm 146 26 4 4 CD cord-023095-4dannjjm 146 27 ) ) -RRB- cord-023095-4dannjjm 146 28 , , , cord-023095-4dannjjm 146 29 amiodarone amiodarone NN cord-023095-4dannjjm 146 30 ( ( -LRB- cord-023095-4dannjjm 146 31 1 1 CD cord-023095-4dannjjm 146 32 ) ) -RRB- cord-023095-4dannjjm 146 33 , , , cord-023095-4dannjjm 146 34 procainamide procainamide NNP cord-023095-4dannjjm 146 35 ( ( -LRB- cord-023095-4dannjjm 146 36 2 2 CD cord-023095-4dannjjm 146 37 ) ) -RRB- cord-023095-4dannjjm 146 38 , , , cord-023095-4dannjjm 146 39 mexiletine mexiletine NNP cord-023095-4dannjjm 146 40 & & CC cord-023095-4dannjjm 146 41 atenolol atenolol NNP cord-023095-4dannjjm 146 42 ( ( -LRB- cord-023095-4dannjjm 146 43 3 3 CD cord-023095-4dannjjm 146 44 ) ) -RRB- cord-023095-4dannjjm 146 45 , , , cord-023095-4dannjjm 146 46 atenolol atenolol NNP cord-023095-4dannjjm 146 47 ( ( -LRB- cord-023095-4dannjjm 146 48 1 1 CD cord-023095-4dannjjm 146 49 ) ) -RRB- cord-023095-4dannjjm 146 50 ) ) -RRB- cord-023095-4dannjjm 146 51 . . . cord-023095-4dannjjm 147 1 Eleven eleven CD cord-023095-4dannjjm 147 2 SD sd NN cord-023095-4dannjjm 147 3 dogs dog NNS cord-023095-4dannjjm 147 4 ( ( -LRB- cord-023095-4dannjjm 147 5 25 25 CD cord-023095-4dannjjm 147 6 % % NN cord-023095-4dannjjm 147 7 ) ) -RRB- cord-023095-4dannjjm 147 8 had have VBD cord-023095-4dannjjm 147 9 decreased decrease VBN cord-023095-4dannjjm 147 10 myocardial myocardial JJ cord-023095-4dannjjm 147 11 systolic systolic JJ cord-023095-4dannjjm 147 12 function function NN cord-023095-4dannjjm 147 13 defined define VBN cord-023095-4dannjjm 147 14 by by IN cord-023095-4dannjjm 147 15 a a DT cord-023095-4dannjjm 147 16 shortening shorten VBG cord-023095-4dannjjm 147 17 fraction fraction NN cord-023095-4dannjjm 147 18 ( ( -LRB- cord-023095-4dannjjm 147 19 % % NN cord-023095-4dannjjm 147 20 FS fs NN cord-023095-4dannjjm 147 21 ) ) -RRB- cord-023095-4dannjjm 148 1 o o UH cord-023095-4dannjjm 149 1 25 25 CD cord-023095-4dannjjm 149 2 % % NN cord-023095-4dannjjm 149 3 ( ( -LRB- cord-023095-4dannjjm 149 4 range range NN cord-023095-4dannjjm 149 5 11 11 CD cord-023095-4dannjjm 149 6 - - SYM cord-023095-4dannjjm 149 7 45 45 CD cord-023095-4dannjjm 149 8 , , , cord-023095-4dannjjm 149 9 mean mean VBP cord-023095-4dannjjm 149 10 5 5 CD cord-023095-4dannjjm 149 11 27 27 CD cord-023095-4dannjjm 149 12 ) ) -RRB- cord-023095-4dannjjm 149 13 on on IN cord-023095-4dannjjm 149 14 the the DT cord-023095-4dannjjm 149 15 most most RBS cord-023095-4dannjjm 149 16 recent recent JJ cord-023095-4dannjjm 149 17 echocardiogram echocardiogram NN cord-023095-4dannjjm 149 18 prior prior RB cord-023095-4dannjjm 149 19 to to IN cord-023095-4dannjjm 149 20 SD SD NNP cord-023095-4dannjjm 149 21 . . . cord-023095-4dannjjm 150 1 Median median JJ cord-023095-4dannjjm 150 2 VPCs/24 vpcs/24 NN cord-023095-4dannjjm 150 3 hours hour NNS cord-023095-4dannjjm 150 4 on on IN cord-023095-4dannjjm 150 5 annual annual JJ cord-023095-4dannjjm 150 6 AECG AECG NNP cord-023095-4dannjjm 150 7 was be VBD cord-023095-4dannjjm 150 8 7,700 7,700 CD cord-023095-4dannjjm 151 1 ( ( -LRB- cord-023095-4dannjjm 151 2 range range NNP cord-023095-4dannjjm 151 3 106 106 CD cord-023095-4dannjjm 151 4 - - SYM cord-023095-4dannjjm 151 5 91,000 91,000 CD cord-023095-4dannjjm 151 6 ) ) -RRB- cord-023095-4dannjjm 151 7 with with IN cord-023095-4dannjjm 151 8 a a DT cord-023095-4dannjjm 151 9 median median JJ cord-023095-4dannjjm 151 10 arrhythmia arrhythmia NN cord-023095-4dannjjm 151 11 grade grade NN cord-023095-4dannjjm 151 12 of of IN cord-023095-4dannjjm 151 13 4 4 CD cord-023095-4dannjjm 151 14 ( ( -LRB- cord-023095-4dannjjm 151 15 range range NNP cord-023095-4dannjjm 151 16 2 2 CD cord-023095-4dannjjm 151 17 - - SYM cord-023095-4dannjjm 151 18 4 4 CD cord-023095-4dannjjm 151 19 ) ) -RRB- cord-023095-4dannjjm 151 20 . . . cord-023095-4dannjjm 152 1 Twenty twenty CD cord-023095-4dannjjm 152 2 one one NN cord-023095-4dannjjm 152 3 contemporaneously contemporaneously RB cord-023095-4dannjjm 152 4 entered enter VBD cord-023095-4dannjjm 152 5 ARVC ARVC NNP cord-023095-4dannjjm 152 6 boxers boxer NNS cord-023095-4dannjjm 152 7 that that WDT cord-023095-4dannjjm 152 8 had have VBD cord-023095-4dannjjm 152 9 survived survive VBN cord-023095-4dannjjm 152 10 to to IN cord-023095-4dannjjm 152 11 at at IN cord-023095-4dannjjm 152 12 least least JJS cord-023095-4dannjjm 152 13 the the DT cord-023095-4dannjjm 152 14 median median JJ cord-023095-4dannjjm 152 15 age age NN cord-023095-4dannjjm 152 16 of of IN cord-023095-4dannjjm 152 17 the the DT cord-023095-4dannjjm 152 18 SD SD NNP cord-023095-4dannjjm 152 19 group group NN cord-023095-4dannjjm 152 20 with with IN cord-023095-4dannjjm 152 21 NSD NSD NNP cord-023095-4dannjjm 152 22 were be VBD cord-023095-4dannjjm 152 23 available available JJ cord-023095-4dannjjm 152 24 for for IN cord-023095-4dannjjm 152 25 comparison comparison NN cord-023095-4dannjjm 152 26 ; ; : cord-023095-4dannjjm 152 27 15/21 15/21 CD cord-023095-4dannjjm 152 28 were be VBD cord-023095-4dannjjm 152 29 genotyped genotype VBN cord-023095-4dannjjm 152 30 ( ( -LRB- cord-023095-4dannjjm 152 31 10 10 CD cord-023095-4dannjjm 152 32 heterozygous heterozygous JJ cord-023095-4dannjjm 152 33 , , , cord-023095-4dannjjm 152 34 1 1 CD cord-023095-4dannjjm 152 35 homozygous homozygous JJ cord-023095-4dannjjm 152 36 , , , cord-023095-4dannjjm 152 37 4 4 CD cord-023095-4dannjjm 152 38 negative negative JJ cord-023095-4dannjjm 152 39 ) ) -RRB- cord-023095-4dannjjm 152 40 , , , cord-023095-4dannjjm 152 41 13 13 CD cord-023095-4dannjjm 152 42 were be VBD cord-023095-4dannjjm 152 43 female female JJ cord-023095-4dannjjm 152 44 ( ( -LRB- cord-023095-4dannjjm 152 45 3 3 CD cord-023095-4dannjjm 152 46 intact intact JJ cord-023095-4dannjjm 152 47 ) ) -RRB- cord-023095-4dannjjm 152 48 and and CC cord-023095-4dannjjm 152 49 8 8 CD cord-023095-4dannjjm 152 50 male male NN cord-023095-4dannjjm 152 51 ( ( -LRB- cord-023095-4dannjjm 152 52 2 2 CD cord-023095-4dannjjm 152 53 intact intact JJ cord-023095-4dannjjm 152 54 ) ) -RRB- cord-023095-4dannjjm 152 55 . . . cord-023095-4dannjjm 153 1 Twelve twelve CD cord-023095-4dannjjm 153 2 NSD NSD NNP cord-023095-4dannjjm 153 3 dogs dog NNS cord-023095-4dannjjm 153 4 ( ( -LRB- cord-023095-4dannjjm 153 5 57 57 CD cord-023095-4dannjjm 153 6 % % NN cord-023095-4dannjjm 153 7 ) ) -RRB- cord-023095-4dannjjm 153 8 had have VBD cord-023095-4dannjjm 153 9 no no DT cord-023095-4dannjjm 153 10 prior prior JJ cord-023095-4dannjjm 153 11 history history NN cord-023095-4dannjjm 153 12 of of IN cord-023095-4dannjjm 153 13 syncope syncope NN cord-023095-4dannjjm 153 14 . . . cord-023095-4dannjjm 154 1 Median median JJ cord-023095-4dannjjm 154 2 NSD NSD NNP cord-023095-4dannjjm 154 3 group group NN cord-023095-4dannjjm 154 4 age age NN cord-023095-4dannjjm 154 5 was be VBD cord-023095-4dannjjm 154 6 10 10 CD cord-023095-4dannjjm 154 7 years year NNS cord-023095-4dannjjm 154 8 ( ( -LRB- cord-023095-4dannjjm 154 9 range range NN cord-023095-4dannjjm 154 10 , , , cord-023095-4dannjjm 154 11 8 8 CD cord-023095-4dannjjm 154 12 - - SYM cord-023095-4dannjjm 154 13 13 13 CD cord-023095-4dannjjm 154 14 ) ) -RRB- cord-023095-4dannjjm 154 15 ; ; : cord-023095-4dannjjm 154 16 11/21 11/21 CD cord-023095-4dannjjm 154 17 ( ( -LRB- cord-023095-4dannjjm 154 18 52 52 CD cord-023095-4dannjjm 154 19 % % NN cord-023095-4dannjjm 154 20 ) ) -RRB- cord-023095-4dannjjm 154 21 were be VBD cord-023095-4dannjjm 154 22 on on IN cord-023095-4dannjjm 154 23 an an DT cord-023095-4dannjjm 154 24 antiarrhythmics antiarrhythmic NNS cord-023095-4dannjjm 154 25 ( ( -LRB- cord-023095-4dannjjm 154 26 sotalol sotalol NNP cord-023095-4dannjjm 154 27 ( ( -LRB- cord-023095-4dannjjm 154 28 9 9 CD cord-023095-4dannjjm 154 29 ) ) -RRB- cord-023095-4dannjjm 154 30 , , , cord-023095-4dannjjm 154 31 mexiletine mexiletine NNP cord-023095-4dannjjm 154 32 & & CC cord-023095-4dannjjm 154 33 sotalol sotalol NNP cord-023095-4dannjjm 154 34 ( ( -LRB- cord-023095-4dannjjm 154 35 1 1 CD cord-023095-4dannjjm 154 36 ) ) -RRB- cord-023095-4dannjjm 154 37 , , , cord-023095-4dannjjm 154 38 mexiletine mexiletine NNP cord-023095-4dannjjm 154 39 & & CC cord-023095-4dannjjm 154 40 atenolol atenolol NNP cord-023095-4dannjjm 154 41 ( ( -LRB- cord-023095-4dannjjm 154 42 1 1 CD cord-023095-4dannjjm 154 43 ) ) -RRB- cord-023095-4dannjjm 154 44 ) ) -RRB- cord-023095-4dannjjm 154 45 . . . cord-023095-4dannjjm 155 1 One one CD cord-023095-4dannjjm 155 2 NSD NSD NNP cord-023095-4dannjjm 155 3 dog dog NN cord-023095-4dannjjm 155 4 had have VBD cord-023095-4dannjjm 155 5 decreased decrease VBN cord-023095-4dannjjm 155 6 % % NN cord-023095-4dannjjm 155 7 FS fs NN cord-023095-4dannjjm 155 8 ( ( -LRB- cord-023095-4dannjjm 155 9 NSD NSD NNP cord-023095-4dannjjm 155 10 group group NN cord-023095-4dannjjm 155 11 % % NN cord-023095-4dannjjm 155 12 FS fs NN cord-023095-4dannjjm 155 13 range range NN cord-023095-4dannjjm 155 14 20 20 CD cord-023095-4dannjjm 155 15 - - SYM cord-023095-4dannjjm 155 16 42 42 CD cord-023095-4dannjjm 155 17 , , , cord-023095-4dannjjm 155 18 mean mean JJ cord-023095-4dannjjm 155 19 5 5 CD cord-023095-4dannjjm 155 20 32 32 CD cord-023095-4dannjjm 155 21 ) ) -RRB- cord-023095-4dannjjm 155 22 . . . cord-023095-4dannjjm 156 1 The the DT cord-023095-4dannjjm 156 2 NSD NSD NNP cord-023095-4dannjjm 156 3 median median JJ cord-023095-4dannjjm 156 4 number number NN cord-023095-4dannjjm 156 5 of of IN cord-023095-4dannjjm 156 6 VPCs vpc NNS cord-023095-4dannjjm 156 7 was be VBD cord-023095-4dannjjm 156 8 5,342 5,342 CD cord-023095-4dannjjm 157 1 ( ( -LRB- cord-023095-4dannjjm 157 2 range range NNP cord-023095-4dannjjm 157 3 622 622 CD cord-023095-4dannjjm 157 4 - - HYPH cord-023095-4dannjjm 157 5 62,622 62,622 CD cord-023095-4dannjjm 157 6 ) ) -RRB- cord-023095-4dannjjm 157 7 , , , cord-023095-4dannjjm 157 8 median median JJ cord-023095-4dannjjm 157 9 arrhythmia arrhythmia NN cord-023095-4dannjjm 157 10 grade grade NN cord-023095-4dannjjm 157 11 was be VBD cord-023095-4dannjjm 157 12 4 4 CD cord-023095-4dannjjm 158 1 ( ( -LRB- cord-023095-4dannjjm 158 2 range range NNP cord-023095-4dannjjm 158 3 2 2 CD cord-023095-4dannjjm 158 4 - - SYM cord-023095-4dannjjm 158 5 4 4 CD cord-023095-4dannjjm 158 6 ) ) -RRB- cord-023095-4dannjjm 158 7 . . . cord-023095-4dannjjm 159 1 Striatin Striatin NNP cord-023095-4dannjjm 159 2 genotype genotype NN cord-023095-4dannjjm 159 3 was be VBD cord-023095-4dannjjm 159 4 significantly significantly RB cord-023095-4dannjjm 159 5 associated associate VBN cord-023095-4dannjjm 159 6 with with IN cord-023095-4dannjjm 159 7 SD sd NN cord-023095-4dannjjm 159 8 . . . cord-023095-4dannjjm 160 1 No no DT cord-023095-4dannjjm 160 2 significant significant JJ cord-023095-4dannjjm 160 3 differences difference NNS cord-023095-4dannjjm 160 4 were be VBD cord-023095-4dannjjm 160 5 found find VBN cord-023095-4dannjjm 160 6 between between IN cord-023095-4dannjjm 160 7 groups group NNS cord-023095-4dannjjm 160 8 with with IN cord-023095-4dannjjm 160 9 respect respect NN cord-023095-4dannjjm 160 10 to to IN cord-023095-4dannjjm 160 11 VPC VPC NNP cord-023095-4dannjjm 160 12 numbers number NNS cord-023095-4dannjjm 160 13 or or CC cord-023095-4dannjjm 160 14 arrhythmia arrhythmia NN cord-023095-4dannjjm 160 15 grade grade NN cord-023095-4dannjjm 160 16 . . . cord-023095-4dannjjm 161 1 Shortening shorten VBG cord-023095-4dannjjm 161 2 fraction fraction NN cord-023095-4dannjjm 161 3 was be VBD cord-023095-4dannjjm 161 4 significantly significantly RB cord-023095-4dannjjm 161 5 lower low JJR cord-023095-4dannjjm 161 6 in in IN cord-023095-4dannjjm 161 7 the the DT cord-023095-4dannjjm 161 8 SD sd NN cord-023095-4dannjjm 161 9 group group NN cord-023095-4dannjjm 161 10 ( ( -LRB- cord-023095-4dannjjm 161 11 p p NN cord-023095-4dannjjm 161 12 o o NN cord-023095-4dannjjm 161 13 0.01 0.01 CD cord-023095-4dannjjm 161 14 ) ) -RRB- cord-023095-4dannjjm 161 15 . . . cord-023095-4dannjjm 162 1 SD SD NNP cord-023095-4dannjjm 162 2 in in IN cord-023095-4dannjjm 162 3 ARVC ARVC NNP cord-023095-4dannjjm 162 4 appears appear VBZ cord-023095-4dannjjm 162 5 to to TO cord-023095-4dannjjm 162 6 be be VB cord-023095-4dannjjm 162 7 associated associate VBN cord-023095-4dannjjm 162 8 with with IN cord-023095-4dannjjm 162 9 the the DT cord-023095-4dannjjm 162 10 presence presence NN cord-023095-4dannjjm 162 11 of of IN cord-023095-4dannjjm 162 12 the the DT cord-023095-4dannjjm 162 13 striatin striatin NNP cord-023095-4dannjjm 162 14 mutation mutation NN cord-023095-4dannjjm 162 15 and and CC cord-023095-4dannjjm 162 16 reduced reduce VBN cord-023095-4dannjjm 162 17 % % NN cord-023095-4dannjjm 162 18 FS fs NN cord-023095-4dannjjm 162 19 , , , cord-023095-4dannjjm 162 20 it -PRON- PRP cord-023095-4dannjjm 162 21 does do VBZ cord-023095-4dannjjm 162 22 not not RB cord-023095-4dannjjm 162 23 appear appear VB cord-023095-4dannjjm 162 24 to to TO cord-023095-4dannjjm 162 25 be be VB cord-023095-4dannjjm 162 26 associated associate VBN cord-023095-4dannjjm 162 27 with with IN cord-023095-4dannjjm 162 28 number number NN cord-023095-4dannjjm 162 29 of of IN cord-023095-4dannjjm 162 30 VPCS VPCS NNP cord-023095-4dannjjm 162 31 or or CC cord-023095-4dannjjm 162 32 arrhythmia arrhythmia NN cord-023095-4dannjjm 162 33 grade grade NN cord-023095-4dannjjm 162 34 . . . cord-023095-4dannjjm 163 1 Coughing cough VBG cord-023095-4dannjjm 163 2 in in IN cord-023095-4dannjjm 163 3 the the DT cord-023095-4dannjjm 163 4 small small JJ cord-023095-4dannjjm 163 5 breed breed NN cord-023095-4dannjjm 163 6 dog dog NN cord-023095-4dannjjm 163 7 may may MD cord-023095-4dannjjm 163 8 be be VB cord-023095-4dannjjm 163 9 related relate VBN cord-023095-4dannjjm 163 10 to to IN cord-023095-4dannjjm 163 11 cardiac cardiac JJ cord-023095-4dannjjm 163 12 causes cause NNS cord-023095-4dannjjm 163 13 associated associate VBN cord-023095-4dannjjm 163 14 with with IN cord-023095-4dannjjm 163 15 myxomatous myxomatous JJ cord-023095-4dannjjm 163 16 mitral mitral JJ cord-023095-4dannjjm 163 17 valve valve NN cord-023095-4dannjjm 163 18 degeneration degeneration NN cord-023095-4dannjjm 163 19 ( ( -LRB- cord-023095-4dannjjm 163 20 MMVD MMVD NNP cord-023095-4dannjjm 163 21 ) ) -RRB- cord-023095-4dannjjm 163 22 including include VBG cord-023095-4dannjjm 163 23 pulmonary pulmonary JJ cord-023095-4dannjjm 163 24 edema edema NN cord-023095-4dannjjm 163 25 and and CC cord-023095-4dannjjm 163 26 compression compression NN cord-023095-4dannjjm 163 27 of of IN cord-023095-4dannjjm 163 28 the the DT cord-023095-4dannjjm 163 29 mainstem mainstem JJ cord-023095-4dannjjm 163 30 bronchus bronchus NN cord-023095-4dannjjm 163 31 by by IN cord-023095-4dannjjm 163 32 a a DT cord-023095-4dannjjm 163 33 severely severely RB cord-023095-4dannjjm 163 34 enlarged enlarge VBN cord-023095-4dannjjm 163 35 left left JJ cord-023095-4dannjjm 163 36 atrium atrium NN cord-023095-4dannjjm 163 37 , , , cord-023095-4dannjjm 163 38 or or CC cord-023095-4dannjjm 163 39 due due IN cord-023095-4dannjjm 163 40 to to IN cord-023095-4dannjjm 163 41 respiratory respiratory JJ cord-023095-4dannjjm 163 42 causes cause NNS cord-023095-4dannjjm 163 43 such such JJ cord-023095-4dannjjm 163 44 as as IN cord-023095-4dannjjm 163 45 tracheal tracheal NN cord-023095-4dannjjm 163 46 and/or and/or CC cord-023095-4dannjjm 163 47 bronchial bronchial JJ cord-023095-4dannjjm 163 48 collapse collapse NN cord-023095-4dannjjm 163 49 or or CC cord-023095-4dannjjm 163 50 chronic chronic JJ cord-023095-4dannjjm 163 51 bronchitis bronchitis NN cord-023095-4dannjjm 163 52 . . . cord-023095-4dannjjm 164 1 The the DT cord-023095-4dannjjm 164 2 purpose purpose NN cord-023095-4dannjjm 164 3 of of IN cord-023095-4dannjjm 164 4 this this DT cord-023095-4dannjjm 164 5 study study NN cord-023095-4dannjjm 164 6 was be VBD cord-023095-4dannjjm 164 7 to to TO cord-023095-4dannjjm 164 8 evaluate evaluate VB cord-023095-4dannjjm 164 9 the the DT cord-023095-4dannjjm 164 10 association association NN cord-023095-4dannjjm 164 11 between between IN cord-023095-4dannjjm 164 12 left left JJ cord-023095-4dannjjm 164 13 atrial atrial JJ cord-023095-4dannjjm 164 14 enlargement enlargement NN cord-023095-4dannjjm 164 15 and and CC cord-023095-4dannjjm 164 16 large large JJ cord-023095-4dannjjm 164 17 airway airway NN cord-023095-4dannjjm 164 18 collapse collapse NN cord-023095-4dannjjm 164 19 in in IN cord-023095-4dannjjm 164 20 dogs dog NNS cord-023095-4dannjjm 164 21 with with IN cord-023095-4dannjjm 164 22 MMVD MMVD NNP cord-023095-4dannjjm 164 23 and and CC cord-023095-4dannjjm 164 24 chronic chronic JJ cord-023095-4dannjjm 164 25 cough cough NN cord-023095-4dannjjm 164 26 . . . cord-023095-4dannjjm 165 1 We -PRON- PRP cord-023095-4dannjjm 165 2 hypothesized hypothesize VBD cord-023095-4dannjjm 165 3 that that IN cord-023095-4dannjjm 165 4 airway airway NN cord-023095-4dannjjm 165 5 collapse collapse NN cord-023095-4dannjjm 165 6 was be VBD cord-023095-4dannjjm 165 7 independent independent JJ cord-023095-4dannjjm 165 8 of of IN cord-023095-4dannjjm 165 9 degree degree NN cord-023095-4dannjjm 165 10 of of IN cord-023095-4dannjjm 165 11 left left JJ cord-023095-4dannjjm 165 12 atrial atrial JJ cord-023095-4dannjjm 165 13 enlargement enlargement NN cord-023095-4dannjjm 165 14 . . . cord-023095-4dannjjm 166 1 Twelve twelve CD cord-023095-4dannjjm 166 2 dogs dog NNS cord-023095-4dannjjm 166 3 with with IN cord-023095-4dannjjm 166 4 MMVD MMVD NNP cord-023095-4dannjjm 166 5 and and CC cord-023095-4dannjjm 166 6 a a DT cord-023095-4dannjjm 166 7 chronic chronic JJ cord-023095-4dannjjm 166 8 cough cough NN cord-023095-4dannjjm 166 9 in in IN cord-023095-4dannjjm 166 10 the the DT cord-023095-4dannjjm 166 11 absence absence NN cord-023095-4dannjjm 166 12 of of IN cord-023095-4dannjjm 166 13 congestive congestive JJ cord-023095-4dannjjm 166 14 heart heart NN cord-023095-4dannjjm 166 15 failure failure NN cord-023095-4dannjjm 166 16 were be VBD cord-023095-4dannjjm 166 17 prospectively prospectively RB cord-023095-4dannjjm 166 18 evaluated evaluate VBN cord-023095-4dannjjm 166 19 with with IN cord-023095-4dannjjm 166 20 thoracic thoracic JJ cord-023095-4dannjjm 166 21 and and CC cord-023095-4dannjjm 166 22 cervical cervical JJ cord-023095-4dannjjm 166 23 radiography radiography NN cord-023095-4dannjjm 166 24 , , , cord-023095-4dannjjm 166 25 echocardiography echocardiography NN cord-023095-4dannjjm 166 26 , , , cord-023095-4dannjjm 166 27 fluoroscopy fluoroscopy NN cord-023095-4dannjjm 166 28 , , , cord-023095-4dannjjm 166 29 bronchoscopy bronchoscopy NN cord-023095-4dannjjm 166 30 and and CC cord-023095-4dannjjm 166 31 bronchoalveolar bronchoalveolar NNP cord-023095-4dannjjm 166 32 lavage lavage NNP cord-023095-4dannjjm 166 33 ( ( -LRB- cord-023095-4dannjjm 166 34 BAL BAL NNP cord-023095-4dannjjm 166 35 ) ) -RRB- cord-023095-4dannjjm 166 36 . . . cord-023095-4dannjjm 167 1 Group group NN cord-023095-4dannjjm 167 2 1 1 CD cord-023095-4dannjjm 167 3 dogs dog NNS cord-023095-4dannjjm 167 4 ( ( -LRB- cord-023095-4dannjjm 167 5 n n NN cord-023095-4dannjjm 167 6 5 5 CD cord-023095-4dannjjm 167 7 8) 8) NNP cord-023095-4dannjjm 167 8 had have VBD cord-023095-4dannjjm 167 9 moderate moderate JJ cord-023095-4dannjjm 167 10 to to TO cord-023095-4dannjjm 167 11 severe severe JJ cord-023095-4dannjjm 167 12 left left JJ cord-023095-4dannjjm 167 13 atrial atrial JJ cord-023095-4dannjjm 167 14 enlargement enlargement NN cord-023095-4dannjjm 167 15 based base VBN cord-023095-4dannjjm 167 16 on on IN cord-023095-4dannjjm 167 17 an an DT cord-023095-4dannjjm 167 18 echocardiographically echocardiographically RB cord-023095-4dannjjm 167 19 calculated calculate VBN cord-023095-4dannjjm 167 20 left left JJ cord-023095-4dannjjm 167 21 atrial atrial NN cord-023095-4dannjjm 167 22 : : : cord-023095-4dannjjm 167 23 aortic aortic JJ cord-023095-4dannjjm 167 24 surface surface NN cord-023095-4dannjjm 167 25 area area NN cord-023095-4dannjjm 167 26 [ [ -LRB- cord-023095-4dannjjm 167 27 LA la NN cord-023095-4dannjjm 167 28 : : : cord-023095-4dannjjm 167 29 Ao(a Ao(a NNP cord-023095-4dannjjm 167 30 ) ) -RRB- cord-023095-4dannjjm 167 31 ] ] -RRB- cord-023095-4dannjjm 168 1 4 4 CD cord-023095-4dannjjm 168 2 6 6 CD cord-023095-4dannjjm 168 3 . . . cord-023095-4dannjjm 169 1 Group group NN cord-023095-4dannjjm 169 2 2 2 CD cord-023095-4dannjjm 169 3 dogs dog NNS cord-023095-4dannjjm 169 4 ( ( -LRB- cord-023095-4dannjjm 169 5 n n NN cord-023095-4dannjjm 169 6 5 5 CD cord-023095-4dannjjm 169 7 4 4 CD cord-023095-4dannjjm 169 8 ) ) -RRB- cord-023095-4dannjjm 169 9 had have VBD cord-023095-4dannjjm 169 10 no no DT cord-023095-4dannjjm 169 11 to to TO cord-023095-4dannjjm 169 12 mild mild VB cord-023095-4dannjjm 169 13 left left JJ cord-023095-4dannjjm 169 14 atrial atrial JJ cord-023095-4dannjjm 169 15 enlargement enlargement NN cord-023095-4dannjjm 169 16 [ [ -LRB- cord-023095-4dannjjm 169 17 LA la NN cord-023095-4dannjjm 169 18 : : : cord-023095-4dannjjm 169 19 Ao(a Ao(a NNP cord-023095-4dannjjm 169 20 ) ) -RRB- cord-023095-4dannjjm 169 21 6 6 CD cord-023095-4dannjjm 169 22 ] ] -RRB- cord-023095-4dannjjm 169 23 . . . cord-023095-4dannjjm 170 1 The the DT cord-023095-4dannjjm 170 2 site site NN cord-023095-4dannjjm 170 3 and and CC cord-023095-4dannjjm 170 4 severity severity NN cord-023095-4dannjjm 170 5 of of IN cord-023095-4dannjjm 170 6 airway airway NN cord-023095-4dannjjm 170 7 collapse collapse NN cord-023095-4dannjjm 170 8 was be VBD cord-023095-4dannjjm 170 9 graded grade VBN cord-023095-4dannjjm 170 10 on on IN cord-023095-4dannjjm 170 11 bronchoscopy bronchoscopy NN cord-023095-4dannjjm 170 12 and and CC cord-023095-4dannjjm 170 13 BAL bal NN cord-023095-4dannjjm 170 14 cytology cytology NN cord-023095-4dannjjm 170 15 was be VBD cord-023095-4dannjjm 170 16 assessed assess VBN cord-023095-4dannjjm 170 17 for for IN cord-023095-4dannjjm 170 18 evidence evidence NN cord-023095-4dannjjm 170 19 of of IN cord-023095-4dannjjm 170 20 inflammation inflammation NN cord-023095-4dannjjm 170 21 or or CC cord-023095-4dannjjm 170 22 infection infection NN cord-023095-4dannjjm 170 23 . . . cord-023095-4dannjjm 171 1 The the DT cord-023095-4dannjjm 171 2 occurrence occurrence NN cord-023095-4dannjjm 171 3 of of IN cord-023095-4dannjjm 171 4 bronchoscopic bronchoscopic NNP cord-023095-4dannjjm 171 5 abnormalities abnormality NNS cord-023095-4dannjjm 171 6 was be VBD cord-023095-4dannjjm 171 7 compared compare VBN cord-023095-4dannjjm 171 8 between between IN cord-023095-4dannjjm 171 9 groups group NNS cord-023095-4dannjjm 171 10 using use VBG cord-023095-4dannjjm 171 11 Fisher Fisher NNP cord-023095-4dannjjm 171 12 's 's POS cord-023095-4dannjjm 171 13 Exact Exact NNP cord-023095-4dannjjm 171 14 Test test NN cord-023095-4dannjjm 171 15 . . . cord-023095-4dannjjm 172 1 P p NN cord-023095-4dannjjm 172 2 o o NN cord-023095-4dannjjm 172 3 0.05 0.05 CD cord-023095-4dannjjm 172 4 was be VBD cord-023095-4dannjjm 172 5 considered consider VBN cord-023095-4dannjjm 172 6 significant significant JJ cord-023095-4dannjjm 172 7 . . . cord-023095-4dannjjm 173 1 Age age NN cord-023095-4dannjjm 173 2 and and CC cord-023095-4dannjjm 173 3 body body NN cord-023095-4dannjjm 173 4 weight weight NN cord-023095-4dannjjm 173 5 did do VBD cord-023095-4dannjjm 173 6 not not RB cord-023095-4dannjjm 173 7 differ differ VB cord-023095-4dannjjm 173 8 between between IN cord-023095-4dannjjm 173 9 groups group NNS cord-023095-4dannjjm 173 10 . . . cord-023095-4dannjjm 174 1 Left leave VBN cord-023095-4dannjjm 174 2 atrial atrial JJ cord-023095-4dannjjm 174 3 size size NN cord-023095-4dannjjm 174 4 was be VBD cord-023095-4dannjjm 174 5 interpreted interpret VBN cord-023095-4dannjjm 174 6 radiographically radiographically RB cord-023095-4dannjjm 174 7 as as RB cord-023095-4dannjjm 174 8 moderately moderately RB cord-023095-4dannjjm 174 9 to to TO cord-023095-4dannjjm 174 10 severely severely RB cord-023095-4dannjjm 174 11 enlarged enlarge VBN cord-023095-4dannjjm 174 12 in in IN cord-023095-4dannjjm 174 13 7 7 CD cord-023095-4dannjjm 174 14 of of IN cord-023095-4dannjjm 174 15 8 8 CD cord-023095-4dannjjm 174 16 dogs dog NNS cord-023095-4dannjjm 174 17 in in IN cord-023095-4dannjjm 174 18 group group NN cord-023095-4dannjjm 174 19 1 1 CD cord-023095-4dannjjm 174 20 and and CC cord-023095-4dannjjm 174 21 as as IN cord-023095-4dannjjm 174 22 moderately moderately RB cord-023095-4dannjjm 174 23 enlarged enlarged JJ cord-023095-4dannjjm 174 24 in in IN cord-023095-4dannjjm 174 25 2 2 CD cord-023095-4dannjjm 174 26 of of IN cord-023095-4dannjjm 174 27 4 4 CD cord-023095-4dannjjm 174 28 dogs dog NNS cord-023095-4dannjjm 174 29 in in IN cord-023095-4dannjjm 174 30 group group NN cord-023095-4dannjjm 174 31 2 2 CD cord-023095-4dannjjm 174 32 . . . cord-023095-4dannjjm 175 1 Fluoroscopy Fluoroscopy NNP cord-023095-4dannjjm 175 2 revealed reveal VBD cord-023095-4dannjjm 175 3 variable variable JJ cord-023095-4dannjjm 175 4 degrees degree NNS cord-023095-4dannjjm 175 5 of of IN cord-023095-4dannjjm 175 6 airway airway NN cord-023095-4dannjjm 175 7 collapse collapse NN cord-023095-4dannjjm 175 8 during during IN cord-023095-4dannjjm 175 9 normal normal JJ cord-023095-4dannjjm 175 10 respiration respiration NN cord-023095-4dannjjm 175 11 and and CC cord-023095-4dannjjm 175 12 induced induce VBN cord-023095-4dannjjm 175 13 cough cough NN cord-023095-4dannjjm 175 14 in in IN cord-023095-4dannjjm 175 15 both both DT cord-023095-4dannjjm 175 16 groups group NNS cord-023095-4dannjjm 175 17 . . . cord-023095-4dannjjm 176 1 Radiography radiography NN cord-023095-4dannjjm 176 2 and and CC cord-023095-4dannjjm 176 3 fluoroscopy fluoroscopy NN cord-023095-4dannjjm 176 4 were be VBD cord-023095-4dannjjm 176 5 not not RB cord-023095-4dannjjm 176 6 accurate accurate JJ cord-023095-4dannjjm 176 7 in in IN cord-023095-4dannjjm 176 8 identifying identify VBG cord-023095-4dannjjm 176 9 site site NN cord-023095-4dannjjm 176 10 and and CC cord-023095-4dannjjm 176 11 degree degree NN cord-023095-4dannjjm 176 12 of of IN cord-023095-4dannjjm 176 13 collapse collapse NN cord-023095-4dannjjm 176 14 in in IN cord-023095-4dannjjm 176 15 either either DT cord-023095-4dannjjm 176 16 group group NN cord-023095-4dannjjm 176 17 when when WRB cord-023095-4dannjjm 176 18 compared compare VBN cord-023095-4dannjjm 176 19 to to IN cord-023095-4dannjjm 176 20 bronchoscopy bronchoscopy NN cord-023095-4dannjjm 176 21 . . . cord-023095-4dannjjm 177 1 Cervical cervical JJ cord-023095-4dannjjm 177 2 tracheal tracheal NN cord-023095-4dannjjm 177 3 collapse collapse NN cord-023095-4dannjjm 177 4 was be VBD cord-023095-4dannjjm 177 5 identified identify VBN cord-023095-4dannjjm 177 6 during during IN cord-023095-4dannjjm 177 7 bronchoscopy bronchoscopy NN cord-023095-4dannjjm 177 8 in in IN cord-023095-4dannjjm 177 9 both both DT cord-023095-4dannjjm 177 10 group group NN cord-023095-4dannjjm 177 11 1 1 CD cord-023095-4dannjjm 177 12 ( ( -LRB- cord-023095-4dannjjm 177 13 2 2 CD cord-023095-4dannjjm 177 14 of of IN cord-023095-4dannjjm 177 15 8) 8) NN cord-023095-4dannjjm 177 16 and and CC cord-023095-4dannjjm 177 17 group group NN cord-023095-4dannjjm 177 18 2 2 CD cord-023095-4dannjjm 177 19 ( ( -LRB- cord-023095-4dannjjm 177 20 3 3 CD cord-023095-4dannjjm 177 21 of of IN cord-023095-4dannjjm 177 22 4 4 CD cord-023095-4dannjjm 177 23 ) ) -RRB- cord-023095-4dannjjm 177 24 dogs dog NNS cord-023095-4dannjjm 177 25 but but CC cord-023095-4dannjjm 177 26 was be VBD cord-023095-4dannjjm 177 27 subjectively subjectively RB cord-023095-4dannjjm 177 28 less less RBR cord-023095-4dannjjm 177 29 severe severe JJ cord-023095-4dannjjm 177 30 in in IN cord-023095-4dannjjm 177 31 group group NN cord-023095-4dannjjm 177 32 1 1 CD cord-023095-4dannjjm 177 33 dogs dog NNS cord-023095-4dannjjm 177 34 . . . cord-023095-4dannjjm 178 1 Bronchial bronchial JJ cord-023095-4dannjjm 178 2 collapse collapse NN cord-023095-4dannjjm 179 1 4 4 CD cord-023095-4dannjjm 179 2 50 50 CD cord-023095-4dannjjm 179 3 % % NN cord-023095-4dannjjm 179 4 was be VBD cord-023095-4dannjjm 179 5 evident evident JJ cord-023095-4dannjjm 179 6 at at IN cord-023095-4dannjjm 179 7 multiple multiple JJ cord-023095-4dannjjm 179 8 sites site NNS cord-023095-4dannjjm 179 9 in in IN cord-023095-4dannjjm 179 10 both both DT cord-023095-4dannjjm 179 11 groups group NNS cord-023095-4dannjjm 179 12 of of IN cord-023095-4dannjjm 179 13 dogs dog NNS cord-023095-4dannjjm 179 14 with with IN cord-023095-4dannjjm 179 15 no no DT cord-023095-4dannjjm 179 16 difference difference NN cord-023095-4dannjjm 179 17 between between IN cord-023095-4dannjjm 179 18 groups group NNS cord-023095-4dannjjm 179 19 . . . cord-023095-4dannjjm 180 1 All all DT cord-023095-4dannjjm 180 2 dogs dog NNS cord-023095-4dannjjm 180 3 had have VBD cord-023095-4dannjjm 180 4 suppurative suppurative JJ cord-023095-4dannjjm 180 5 and/or and/or CC cord-023095-4dannjjm 180 6 lymphocytic lymphocytic JJ cord-023095-4dannjjm 180 7 inflammation inflammation NN cord-023095-4dannjjm 180 8 on on IN cord-023095-4dannjjm 180 9 airway airway NN cord-023095-4dannjjm 180 10 cytology cytology NN cord-023095-4dannjjm 180 11 . . . cord-023095-4dannjjm 181 1 Infection infection NN cord-023095-4dannjjm 181 2 was be VBD cord-023095-4dannjjm 181 3 not not RB cord-023095-4dannjjm 181 4 present present JJ cord-023095-4dannjjm 181 5 in in IN cord-023095-4dannjjm 181 6 either either DT cord-023095-4dannjjm 181 7 group group NN cord-023095-4dannjjm 181 8 of of IN cord-023095-4dannjjm 181 9 dogs dog NNS cord-023095-4dannjjm 181 10 , , , cord-023095-4dannjjm 181 11 although although IN cord-023095-4dannjjm 181 12 non non JJ cord-023095-4dannjjm 181 13 - - JJ cord-023095-4dannjjm 181 14 specific specific JJ cord-023095-4dannjjm 181 15 light light JJ cord-023095-4dannjjm 181 16 bacterial bacterial JJ cord-023095-4dannjjm 181 17 growth growth NN cord-023095-4dannjjm 181 18 was be VBD cord-023095-4dannjjm 181 19 detected detect VBN cord-023095-4dannjjm 181 20 in in IN cord-023095-4dannjjm 181 21 6 6 CD cord-023095-4dannjjm 181 22 of of IN cord-023095-4dannjjm 181 23 8 8 CD cord-023095-4dannjjm 181 24 group group NN cord-023095-4dannjjm 181 25 1 1 CD cord-023095-4dannjjm 181 26 dogs dog NNS cord-023095-4dannjjm 181 27 and and CC cord-023095-4dannjjm 181 28 1 1 CD cord-023095-4dannjjm 181 29 of of IN cord-023095-4dannjjm 181 30 4 4 CD cord-023095-4dannjjm 181 31 group group NN cord-023095-4dannjjm 181 32 2 2 CD cord-023095-4dannjjm 181 33 dogs dog NNS cord-023095-4dannjjm 181 34 ( ( -LRB- cord-023095-4dannjjm 181 35 p p NN cord-023095-4dannjjm 181 36 5 5 CD cord-023095-4dannjjm 181 37 0.22 0.22 CD cord-023095-4dannjjm 181 38 ) ) -RRB- cord-023095-4dannjjm 181 39 . . . cord-023095-4dannjjm 182 1 Preliminary preliminary JJ cord-023095-4dannjjm 182 2 results result NNS cord-023095-4dannjjm 182 3 failed fail VBD cord-023095-4dannjjm 182 4 to to TO cord-023095-4dannjjm 182 5 identify identify VB cord-023095-4dannjjm 182 6 an an DT cord-023095-4dannjjm 182 7 association association NN cord-023095-4dannjjm 182 8 between between IN cord-023095-4dannjjm 182 9 left left JJ cord-023095-4dannjjm 182 10 atrial atrial JJ cord-023095-4dannjjm 182 11 enlargement enlargement NN cord-023095-4dannjjm 182 12 and and CC cord-023095-4dannjjm 182 13 airway airway NN cord-023095-4dannjjm 182 14 collapse collapse NN cord-023095-4dannjjm 182 15 in in IN cord-023095-4dannjjm 182 16 dogs dog NNS cord-023095-4dannjjm 182 17 with with IN cord-023095-4dannjjm 182 18 MMVD MMVD NNP cord-023095-4dannjjm 182 19 but but CC cord-023095-4dannjjm 182 20 did do VBD cord-023095-4dannjjm 182 21 suggest suggest VB cord-023095-4dannjjm 182 22 that that IN cord-023095-4dannjjm 182 23 airway airway JJ cord-023095-4dannjjm 182 24 inflammation inflammation NN cord-023095-4dannjjm 182 25 is be VBZ cord-023095-4dannjjm 182 26 common common JJ cord-023095-4dannjjm 182 27 in in IN cord-023095-4dannjjm 182 28 affected affected JJ cord-023095-4dannjjm 182 29 dogs dog NNS cord-023095-4dannjjm 182 30 . . . cord-023095-4dannjjm 183 1 Further further JJ cord-023095-4dannjjm 183 2 studies study NNS cord-023095-4dannjjm 183 3 are be VBP cord-023095-4dannjjm 183 4 needed need VBN cord-023095-4dannjjm 183 5 to to TO cord-023095-4dannjjm 183 6 identify identify VB cord-023095-4dannjjm 183 7 factors factor NNS cord-023095-4dannjjm 183 8 contributing contribute VBG cord-023095-4dannjjm 183 9 to to IN cord-023095-4dannjjm 183 10 airway airway NN cord-023095-4dannjjm 183 11 collapse collapse NN cord-023095-4dannjjm 183 12 in in IN cord-023095-4dannjjm 183 13 dogs dog NNS cord-023095-4dannjjm 183 14 with with IN cord-023095-4dannjjm 183 15 and and CC cord-023095-4dannjjm 183 16 without without IN cord-023095-4dannjjm 183 17 MMVD MMVD NNP cord-023095-4dannjjm 183 18 . . . cord-023095-4dannjjm 184 1 Atenolol Atenolol NNP cord-023095-4dannjjm 184 2 is be VBZ cord-023095-4dannjjm 184 3 often often RB cord-023095-4dannjjm 184 4 used use VBN cord-023095-4dannjjm 184 5 empirically empirically RB cord-023095-4dannjjm 184 6 in in IN cord-023095-4dannjjm 184 7 cats cat NNS cord-023095-4dannjjm 184 8 with with IN cord-023095-4dannjjm 184 9 asymptomatic asymptomatic JJ cord-023095-4dannjjm 184 10 HCM HCM NNP cord-023095-4dannjjm 184 11 , , , cord-023095-4dannjjm 184 12 even even RB cord-023095-4dannjjm 184 13 though though IN cord-023095-4dannjjm 184 14 clinical clinical JJ cord-023095-4dannjjm 184 15 and and CC cord-023095-4dannjjm 184 16 experimental experimental JJ cord-023095-4dannjjm 184 17 evidence evidence NN cord-023095-4dannjjm 184 18 of of IN cord-023095-4dannjjm 184 19 efficacy efficacy NN cord-023095-4dannjjm 184 20 is be VBZ cord-023095-4dannjjm 184 21 lacking lack VBG cord-023095-4dannjjm 184 22 . . . cord-023095-4dannjjm 185 1 Cardiac cardiac JJ cord-023095-4dannjjm 185 2 biomarkers biomarker NNS cord-023095-4dannjjm 185 3 play play VBP cord-023095-4dannjjm 185 4 a a DT cord-023095-4dannjjm 185 5 critical critical JJ cord-023095-4dannjjm 185 6 role role NN cord-023095-4dannjjm 185 7 in in IN cord-023095-4dannjjm 185 8 the the DT cord-023095-4dannjjm 185 9 early early JJ cord-023095-4dannjjm 185 10 detection detection NN cord-023095-4dannjjm 185 11 of of IN cord-023095-4dannjjm 185 12 subclinical subclinical JJ cord-023095-4dannjjm 185 13 cardiac cardiac JJ cord-023095-4dannjjm 185 14 disease disease NN cord-023095-4dannjjm 185 15 , , , cord-023095-4dannjjm 185 16 in in IN cord-023095-4dannjjm 185 17 the the DT cord-023095-4dannjjm 185 18 prediction prediction NN cord-023095-4dannjjm 185 19 of of IN cord-023095-4dannjjm 185 20 long long JJ cord-023095-4dannjjm 185 21 - - HYPH cord-023095-4dannjjm 185 22 term term NN cord-023095-4dannjjm 185 23 prognosis prognosis NN cord-023095-4dannjjm 185 24 , , , cord-023095-4dannjjm 185 25 and and CC cord-023095-4dannjjm 185 26 in in IN cord-023095-4dannjjm 185 27 monitoring monitor VBG cord-023095-4dannjjm 185 28 the the DT cord-023095-4dannjjm 185 29 response response NN cord-023095-4dannjjm 185 30 to to IN cord-023095-4dannjjm 185 31 therapy therapy NN cord-023095-4dannjjm 185 32 in in IN cord-023095-4dannjjm 185 33 humans human NNS cord-023095-4dannjjm 185 34 . . . cord-023095-4dannjjm 186 1 We -PRON- PRP cord-023095-4dannjjm 186 2 hypothesized hypothesize VBD cord-023095-4dannjjm 186 3 that that IN cord-023095-4dannjjm 186 4 serum serum NN cord-023095-4dannjjm 186 5 concentrations concentration NNS cord-023095-4dannjjm 186 6 of of IN cord-023095-4dannjjm 186 7 the the DT cord-023095-4dannjjm 186 8 biomarkers biomarker NNS cord-023095-4dannjjm 186 9 , , , cord-023095-4dannjjm 186 10 Nterminal Nterminal NNP cord-023095-4dannjjm 186 11 pro pro JJ cord-023095-4dannjjm 186 12 - - JJ cord-023095-4dannjjm 186 13 brain brain JJ cord-023095-4dannjjm 186 14 natriuretic natriuretic JJ cord-023095-4dannjjm 186 15 peptide peptide NN cord-023095-4dannjjm 186 16 ( ( -LRB- cord-023095-4dannjjm 186 17 NT NT NNP cord-023095-4dannjjm 186 18 - - HYPH cord-023095-4dannjjm 186 19 proBNP proBNP NNP cord-023095-4dannjjm 186 20 ) ) -RRB- cord-023095-4dannjjm 186 21 and and CC cord-023095-4dannjjm 186 22 cardiac cardiac NN cord-023095-4dannjjm 186 23 troponin troponin NN cord-023095-4dannjjm 186 24 I -PRON- PRP cord-023095-4dannjjm 186 25 ( ( -LRB- cord-023095-4dannjjm 186 26 cTnI cTnI NNP cord-023095-4dannjjm 186 27 ) ) -RRB- cord-023095-4dannjjm 186 28 , , , cord-023095-4dannjjm 186 29 would would MD cord-023095-4dannjjm 186 30 improve improve VB cord-023095-4dannjjm 186 31 following follow VBG cord-023095-4dannjjm 186 32 the the DT cord-023095-4dannjjm 186 33 chronic chronic JJ cord-023095-4dannjjm 186 34 administration administration NN cord-023095-4dannjjm 186 35 of of IN cord-023095-4dannjjm 186 36 atenolol atenolol NNP cord-023095-4dannjjm 186 37 PO PO NNP cord-023095-4dannjjm 186 38 to to IN cord-023095-4dannjjm 186 39 asymptomatic asymptomatic JJ cord-023095-4dannjjm 186 40 cats cat NNS cord-023095-4dannjjm 186 41 with with IN cord-023095-4dannjjm 186 42 HCM HCM NNP cord-023095-4dannjjm 186 43 . . . cord-023095-4dannjjm 187 1 Six six CD cord-023095-4dannjjm 187 2 Maine Maine NNP cord-023095-4dannjjm 187 3 Coon Coon NNP cord-023095-4dannjjm 187 4 or or CC cord-023095-4dannjjm 187 5 Maine Maine NNP cord-023095-4dannjjm 187 6 Coon Coon NNP cord-023095-4dannjjm 187 7 cross cross NN cord-023095-4dannjjm 187 8 cats cat NNS cord-023095-4dannjjm 187 9 with with IN cord-023095-4dannjjm 187 10 severe severe JJ cord-023095-4dannjjm 187 11 HCM HCM NNP cord-023095-4dannjjm 187 12 from from IN cord-023095-4dannjjm 187 13 the the DT cord-023095-4dannjjm 187 14 research research NN cord-023095-4dannjjm 187 15 colony colony NN cord-023095-4dannjjm 187 16 at at IN cord-023095-4dannjjm 187 17 UCDavis UCDavis NNP cord-023095-4dannjjm 187 18 were be VBD cord-023095-4dannjjm 187 19 administered administer VBN cord-023095-4dannjjm 187 20 atenolol atenolol NN cord-023095-4dannjjm 187 21 ( ( -LRB- cord-023095-4dannjjm 187 22 12.5 12.5 CD cord-023095-4dannjjm 187 23 mg mg NNP cord-023095-4dannjjm 187 24 PO PO NNP cord-023095-4dannjjm 187 25 twice twice PDT cord-023095-4dannjjm 187 26 a a DT cord-023095-4dannjjm 187 27 day day NN cord-023095-4dannjjm 187 28 ) ) -RRB- cord-023095-4dannjjm 187 29 for for IN cord-023095-4dannjjm 187 30 30 30 CD cord-023095-4dannjjm 187 31 days day NNS cord-023095-4dannjjm 187 32 . . . cord-023095-4dannjjm 188 1 No no DT cord-023095-4dannjjm 188 2 cat cat NN cord-023095-4dannjjm 188 3 had have VBD cord-023095-4dannjjm 188 4 severe severe RB cord-023095-4dannjjm 188 5 left leave VBN cord-023095-4dannjjm 188 6 ventricular ventricular JJ cord-023095-4dannjjm 188 7 dynamic dynamic JJ cord-023095-4dannjjm 188 8 outflow outflow NN cord-023095-4dannjjm 188 9 tract tract NN cord-023095-4dannjjm 188 10 obstruction obstruction NN cord-023095-4dannjjm 188 11 due due JJ cord-023095-4dannjjm 188 12 to to IN cord-023095-4dannjjm 188 13 systolic systolic JJ cord-023095-4dannjjm 188 14 anterior anterior JJ cord-023095-4dannjjm 188 15 motion motion NN cord-023095-4dannjjm 188 16 of of IN cord-023095-4dannjjm 188 17 the the DT cord-023095-4dannjjm 188 18 mitral mitral JJ cord-023095-4dannjjm 188 19 valve valve NN cord-023095-4dannjjm 188 20 . . . cord-023095-4dannjjm 189 1 The the DT cord-023095-4dannjjm 189 2 concentrations concentration NNS cord-023095-4dannjjm 189 3 of of IN cord-023095-4dannjjm 189 4 NT NT NNP cord-023095-4dannjjm 189 5 - - HYPH cord-023095-4dannjjm 189 6 proBNP probnp NN cord-023095-4dannjjm 189 7 and and CC cord-023095-4dannjjm 189 8 cTnI cTnI NNP cord-023095-4dannjjm 189 9 were be VBD cord-023095-4dannjjm 189 10 assayed assay VBN cord-023095-4dannjjm 189 11 prior prior RB cord-023095-4dannjjm 189 12 to to IN cord-023095-4dannjjm 189 13 drug drug NN cord-023095-4dannjjm 189 14 administration administration NN cord-023095-4dannjjm 189 15 and and CC cord-023095-4dannjjm 189 16 on on IN cord-023095-4dannjjm 189 17 the the DT cord-023095-4dannjjm 189 18 last last JJ cord-023095-4dannjjm 189 19 day day NN cord-023095-4dannjjm 189 20 of of IN cord-023095-4dannjjm 189 21 drug drug NN cord-023095-4dannjjm 189 22 administration administration NN cord-023095-4dannjjm 189 23 . . . cord-023095-4dannjjm 190 1 There there EX cord-023095-4dannjjm 190 2 was be VBD cord-023095-4dannjjm 190 3 no no DT cord-023095-4dannjjm 190 4 statistically statistically RB cord-023095-4dannjjm 190 5 significant significant JJ cord-023095-4dannjjm 190 6 difference difference NN cord-023095-4dannjjm 190 7 identified identify VBN cord-023095-4dannjjm 190 8 in in IN cord-023095-4dannjjm 190 9 NT NT NNP cord-023095-4dannjjm 190 10 - - HYPH cord-023095-4dannjjm 190 11 proBNP probnp NN cord-023095-4dannjjm 190 12 [ [ -LRB- cord-023095-4dannjjm 190 13 median median NN cord-023095-4dannjjm 190 14 before before RB cord-023095-4dannjjm 190 15 : : : cord-023095-4dannjjm 190 16 394 394 CD cord-023095-4dannjjm 190 17 pmol pmol NNP cord-023095-4dannjjm 190 18 / / SYM cord-023095-4dannjjm 190 19 L l NN cord-023095-4dannjjm 190 20 ( ( -LRB- cord-023095-4dannjjm 190 21 range range NN cord-023095-4dannjjm 190 22 : : : cord-023095-4dannjjm 190 23 71 71 CD cord-023095-4dannjjm 190 24 - - SYM cord-023095-4dannjjm 190 25 1500 1500 CD cord-023095-4dannjjm 190 26 pmol pmol NNP cord-023095-4dannjjm 190 27 / / SYM cord-023095-4dannjjm 190 28 L L NNP cord-023095-4dannjjm 190 29 ) ) -RRB- cord-023095-4dannjjm 190 30 , , . cord-023095-4dannjjm 191 1 median median NN cord-023095-4dannjjm 191 2 after after RB cord-023095-4dannjjm 191 3 : : : cord-023095-4dannjjm 191 4 439 439 CD cord-023095-4dannjjm 191 5 pmol pmol NNP cord-023095-4dannjjm 191 6 / / SYM cord-023095-4dannjjm 191 7 L l NN cord-023095-4dannjjm 191 8 ( ( -LRB- cord-023095-4dannjjm 191 9 range range NN cord-023095-4dannjjm 191 10 : : : cord-023095-4dannjjm 191 11 24 24 CD cord-023095-4dannjjm 191 12 - - SYM cord-023095-4dannjjm 191 13 1500 1500 CD cord-023095-4dannjjm 191 14 pmol pmol NNP cord-023095-4dannjjm 191 15 / / SYM cord-023095-4dannjjm 191 16 L L NNP cord-023095-4dannjjm 191 17 ) ) -RRB- cord-023095-4dannjjm 191 18 ; ; : cord-023095-4dannjjm 191 19 p p NN cord-023095-4dannjjm 191 20 5 5 CD cord-023095-4dannjjm 191 21 0.63 0.63 CD cord-023095-4dannjjm 191 22 ] ] -RRB- cord-023095-4dannjjm 191 23 or or CC cord-023095-4dannjjm 191 24 cTnI ctni XX cord-023095-4dannjjm 192 1 [ [ -LRB- cord-023095-4dannjjm 192 2 median median NN cord-023095-4dannjjm 192 3 before before RB cord-023095-4dannjjm 192 4 : : : cord-023095-4dannjjm 192 5 0.24 0.24 CD cord-023095-4dannjjm 192 6 ng ng NNP cord-023095-4dannjjm 192 7 / / SYM cord-023095-4dannjjm 192 8 ml ml NN cord-023095-4dannjjm 193 1 ( ( -LRB- cord-023095-4dannjjm 193 2 range:0.10 range:0.10 NN cord-023095-4dannjjm 193 3 - - HYPH cord-023095-4dannjjm 193 4 0.97 0.97 CD cord-023095-4dannjjm 193 5 ng ng NN cord-023095-4dannjjm 193 6 / / SYM cord-023095-4dannjjm 193 7 ml ml NNP cord-023095-4dannjjm 193 8 ) ) -RRB- cord-023095-4dannjjm 193 9 , , . cord-023095-4dannjjm 194 1 median median NN cord-023095-4dannjjm 194 2 after after RB cord-023095-4dannjjm 194 3 : : : cord-023095-4dannjjm 194 4 0.28 0.28 CD cord-023095-4dannjjm 194 5 ng ng NNP cord-023095-4dannjjm 194 6 / / SYM cord-023095-4dannjjm 194 7 ml ml NN cord-023095-4dannjjm 195 1 ( ( -LRB- cord-023095-4dannjjm 195 2 range range NN cord-023095-4dannjjm 195 3 : : : cord-023095-4dannjjm 195 4 0.09 0.09 CD cord-023095-4dannjjm 195 5 - - SYM cord-023095-4dannjjm 195 6 1.0 1.0 CD cord-023095-4dannjjm 195 7 ng ng NN cord-023095-4dannjjm 195 8 / / SYM cord-023095-4dannjjm 195 9 ml ml NN cord-023095-4dannjjm 195 10 ) ) -RRB- cord-023095-4dannjjm 195 11 ; ; : cord-023095-4dannjjm 195 12 p p NN cord-023095-4dannjjm 195 13 5 5 CD cord-023095-4dannjjm 195 14 0.69 0.69 CD cord-023095-4dannjjm 195 15 ] ] -RRB- cord-023095-4dannjjm 195 16 concentrations concentration NNS cord-023095-4dannjjm 195 17 before before IN cord-023095-4dannjjm 195 18 and and CC cord-023095-4dannjjm 195 19 after after IN cord-023095-4dannjjm 195 20 drug drug NN cord-023095-4dannjjm 195 21 administration administration NN cord-023095-4dannjjm 195 22 using use VBG cord-023095-4dannjjm 195 23 the the DT cord-023095-4dannjjm 195 24 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 195 25 matched match VBN cord-023095-4dannjjm 195 26 pairs pair NNS cord-023095-4dannjjm 195 27 test test VBP cord-023095-4dannjjm 195 28 . . . cord-023095-4dannjjm 196 1 The the DT cord-023095-4dannjjm 196 2 cTnI cTnI NNP cord-023095-4dannjjm 196 3 finding finding NN cord-023095-4dannjjm 196 4 suggests suggest VBZ cord-023095-4dannjjm 196 5 that that IN cord-023095-4dannjjm 196 6 atenolol atenolol NN cord-023095-4dannjjm 196 7 does do VBZ cord-023095-4dannjjm 196 8 not not RB cord-023095-4dannjjm 196 9 reduce reduce VB cord-023095-4dannjjm 196 10 chronic chronic JJ cord-023095-4dannjjm 196 11 myocyte myocyte NN cord-023095-4dannjjm 196 12 death death NN cord-023095-4dannjjm 196 13 in in IN cord-023095-4dannjjm 196 14 cats cat NNS cord-023095-4dannjjm 196 15 with with IN cord-023095-4dannjjm 196 16 HCM HCM NNP cord-023095-4dannjjm 196 17 . . . cord-023095-4dannjjm 197 1 The the DT cord-023095-4dannjjm 197 2 lack lack NN cord-023095-4dannjjm 197 3 of of IN cord-023095-4dannjjm 197 4 improvement improvement NN cord-023095-4dannjjm 197 5 in in IN cord-023095-4dannjjm 197 6 NT NT NNP cord-023095-4dannjjm 197 7 - - HYPH cord-023095-4dannjjm 197 8 proBNP proBNP NNP cord-023095-4dannjjm 197 9 suggests suggest VBZ cord-023095-4dannjjm 197 10 that that IN cord-023095-4dannjjm 197 11 atenolol atenolol NN cord-023095-4dannjjm 197 12 does do VBZ cord-023095-4dannjjm 197 13 not not RB cord-023095-4dannjjm 197 14 improve improve VB cord-023095-4dannjjm 197 15 myocardial myocardial JJ cord-023095-4dannjjm 197 16 wall wall NN cord-023095-4dannjjm 197 17 stress stress NN cord-023095-4dannjjm 197 18 in in IN cord-023095-4dannjjm 197 19 cats cat NNS cord-023095-4dannjjm 197 20 with with IN cord-023095-4dannjjm 197 21 HCM HCM NNP cord-023095-4dannjjm 197 22 . . . cord-023095-4dannjjm 198 1 A a DT cord-023095-4dannjjm 198 2 clinical clinical JJ cord-023095-4dannjjm 198 3 trial trial NN cord-023095-4dannjjm 198 4 is be VBZ cord-023095-4dannjjm 198 5 warranted warrant VBN cord-023095-4dannjjm 198 6 to to TO cord-023095-4dannjjm 198 7 confirm confirm VB cord-023095-4dannjjm 198 8 or or CC cord-023095-4dannjjm 198 9 refute refute VB cord-023095-4dannjjm 198 10 the the DT cord-023095-4dannjjm 198 11 findings finding NNS cord-023095-4dannjjm 198 12 from from IN cord-023095-4dannjjm 198 13 this this DT cord-023095-4dannjjm 198 14 study study NN cord-023095-4dannjjm 198 15 . . . cord-023095-4dannjjm 199 1 Therefore therefore RB cord-023095-4dannjjm 199 2 , , , cord-023095-4dannjjm 199 3 leptin leptin NN cord-023095-4dannjjm 199 4 - - HYPH cord-023095-4dannjjm 199 5 gene gene NN cord-023095-4dannjjm 199 6 expression expression NN cord-023095-4dannjjm 199 7 was be VBD cord-023095-4dannjjm 199 8 investigated investigate VBN cord-023095-4dannjjm 199 9 in in IN cord-023095-4dannjjm 199 10 blood blood NN cord-023095-4dannjjm 199 11 samples sample NNS cord-023095-4dannjjm 199 12 of of IN cord-023095-4dannjjm 199 13 dogs dog NNS cord-023095-4dannjjm 199 14 with with IN cord-023095-4dannjjm 199 15 congestive congestive JJ cord-023095-4dannjjm 199 16 heart heart NN cord-023095-4dannjjm 199 17 failure failure NN cord-023095-4dannjjm 199 18 ( ( -LRB- cord-023095-4dannjjm 199 19 CHF CHF NNP cord-023095-4dannjjm 199 20 ; ; : cord-023095-4dannjjm 199 21 n n NN cord-023095-4dannjjm 199 22 5 5 CD cord-023095-4dannjjm 199 23 8) 8) NN cord-023095-4dannjjm 199 24 in in IN cord-023095-4dannjjm 199 25 comparison comparison NN cord-023095-4dannjjm 199 26 to to IN cord-023095-4dannjjm 199 27 dogs dog NNS cord-023095-4dannjjm 199 28 presented present VBN cord-023095-4dannjjm 199 29 for for IN cord-023095-4dannjjm 199 30 cardiac cardiac JJ cord-023095-4dannjjm 199 31 screening screening NN cord-023095-4dannjjm 199 32 ( ( -LRB- cord-023095-4dannjjm 199 33 n n NN cord-023095-4dannjjm 199 34 5 5 CD cord-023095-4dannjjm 199 35 8) 8) NN cord-023095-4dannjjm 199 36 without without IN cord-023095-4dannjjm 199 37 abnormalities abnormality NNS cord-023095-4dannjjm 199 38 . . . cord-023095-4dannjjm 200 1 Additionally additionally RB cord-023095-4dannjjm 200 2 myocardial myocardial JJ cord-023095-4dannjjm 200 3 samples sample NNS cord-023095-4dannjjm 200 4 ( ( -LRB- cord-023095-4dannjjm 200 5 interventricular interventricular NNP cord-023095-4dannjjm 200 6 septum septum NN cord-023095-4dannjjm 200 7 , , , cord-023095-4dannjjm 200 8 right right UH cord-023095-4dannjjm 200 9 and and CC cord-023095-4dannjjm 200 10 left left JJ cord-023095-4dannjjm 200 11 atrium atrium NN cord-023095-4dannjjm 200 12 and and CC cord-023095-4dannjjm 200 13 ventricle ventricle NNP cord-023095-4dannjjm 200 14 ) ) -RRB- cord-023095-4dannjjm 200 15 of of IN cord-023095-4dannjjm 200 16 10 10 CD cord-023095-4dannjjm 200 17 dogs dog NNS cord-023095-4dannjjm 200 18 with with IN cord-023095-4dannjjm 200 19 no no DT cord-023095-4dannjjm 200 20 cardiac cardiac JJ cord-023095-4dannjjm 200 21 abnormalities abnormality NNS cord-023095-4dannjjm 200 22 ( ( -LRB- cord-023095-4dannjjm 200 23 controls control NNS cord-023095-4dannjjm 200 24 ) ) -RRB- cord-023095-4dannjjm 200 25 , , , cord-023095-4dannjjm 200 26 seven seven CD cord-023095-4dannjjm 200 27 dogs dog NNS cord-023095-4dannjjm 200 28 with with IN cord-023095-4dannjjm 200 29 acquired acquire VBN cord-023095-4dannjjm 200 30 and and CC cord-023095-4dannjjm 200 31 three three CD cord-023095-4dannjjm 200 32 with with IN cord-023095-4dannjjm 200 33 congenital congenital JJ cord-023095-4dannjjm 200 34 cardiac cardiac JJ cord-023095-4dannjjm 200 35 diseases disease NNS cord-023095-4dannjjm 200 36 were be VBD cord-023095-4dannjjm 200 37 investigated investigate VBN cord-023095-4dannjjm 200 38 using use VBG cord-023095-4dannjjm 200 39 quantitative quantitative JJ cord-023095-4dannjjm 200 40 RT RT NNP cord-023095-4dannjjm 200 41 - - HYPH cord-023095-4dannjjm 200 42 PCR PCR NNP cord-023095-4dannjjm 200 43 . . . cord-023095-4dannjjm 201 1 Leptin leptin NN cord-023095-4dannjjm 201 2 blood blood NN cord-023095-4dannjjm 201 3 levels level NNS cord-023095-4dannjjm 201 4 were be VBD cord-023095-4dannjjm 201 5 significantly significantly RB cord-023095-4dannjjm 201 6 higher high JJR cord-023095-4dannjjm 201 7 in in IN cord-023095-4dannjjm 201 8 dogs dog NNS cord-023095-4dannjjm 201 9 with with IN cord-023095-4dannjjm 201 10 CHF CHF NNP cord-023095-4dannjjm 201 11 in in IN cord-023095-4dannjjm 201 12 comparison comparison NN cord-023095-4dannjjm 201 13 to to IN cord-023095-4dannjjm 201 14 dogs dog NNS cord-023095-4dannjjm 201 15 without without IN cord-023095-4dannjjm 201 16 diseases disease NNS cord-023095-4dannjjm 201 17 ( ( -LRB- cord-023095-4dannjjm 201 18 p p NN cord-023095-4dannjjm 201 19 5 5 CD cord-023095-4dannjjm 201 20 0.013 0.013 CD cord-023095-4dannjjm 201 21 ) ) -RRB- cord-023095-4dannjjm 201 22 . . . cord-023095-4dannjjm 202 1 There there EX cord-023095-4dannjjm 202 2 was be VBD cord-023095-4dannjjm 202 3 an an DT cord-023095-4dannjjm 202 4 association association NN cord-023095-4dannjjm 202 5 with with IN cord-023095-4dannjjm 202 6 gender gender NN cord-023095-4dannjjm 202 7 with with IN cord-023095-4dannjjm 202 8 higher high JJR cord-023095-4dannjjm 202 9 myocardial myocardial JJ cord-023095-4dannjjm 202 10 leptin leptin NN cord-023095-4dannjjm 202 11 levels level NNS cord-023095-4dannjjm 202 12 in in IN cord-023095-4dannjjm 202 13 female female JJ cord-023095-4dannjjm 202 14 dogs dog NNS cord-023095-4dannjjm 202 15 with with IN cord-023095-4dannjjm 202 16 cardiac cardiac JJ cord-023095-4dannjjm 202 17 diseases disease NNS cord-023095-4dannjjm 202 18 ( ( -LRB- cord-023095-4dannjjm 202 19 p p NN cord-023095-4dannjjm 202 20 5 5 CD cord-023095-4dannjjm 202 21 0.001 0.001 CD cord-023095-4dannjjm 202 22 ) ) -RRB- cord-023095-4dannjjm 202 23 . . . cord-023095-4dannjjm 203 1 Differences difference NNS cord-023095-4dannjjm 203 2 between between IN cord-023095-4dannjjm 203 3 cardiac cardiac JJ cord-023095-4dannjjm 203 4 regions region NNS cord-023095-4dannjjm 203 5 were be VBD cord-023095-4dannjjm 203 6 present present JJ cord-023095-4dannjjm 203 7 ( ( -LRB- cord-023095-4dannjjm 203 8 p p NN cord-023095-4dannjjm 203 9 o o NN cord-023095-4dannjjm 203 10 0.05 0.05 CD cord-023095-4dannjjm 203 11 ) ) -RRB- cord-023095-4dannjjm 203 12 and and CC cord-023095-4dannjjm 203 13 cardiac cardiac JJ cord-023095-4dannjjm 203 14 diseases disease NNS cord-023095-4dannjjm 203 15 resulted result VBD cord-023095-4dannjjm 203 16 in in IN cord-023095-4dannjjm 203 17 an an DT cord-023095-4dannjjm 203 18 increase increase NN cord-023095-4dannjjm 203 19 in in IN cord-023095-4dannjjm 203 20 atrial atrial JJ cord-023095-4dannjjm 203 21 leptin leptin NN cord-023095-4dannjjm 203 22 levels level NNS cord-023095-4dannjjm 203 23 in in IN cord-023095-4dannjjm 203 24 both both DT cord-023095-4dannjjm 203 25 sexes sex NNS cord-023095-4dannjjm 203 26 ( ( -LRB- cord-023095-4dannjjm 203 27 p p NN cord-023095-4dannjjm 203 28 5 5 CD cord-023095-4dannjjm 203 29 0.006 0.006 CD cord-023095-4dannjjm 203 30 ) ) -RRB- cord-023095-4dannjjm 203 31 . . . cord-023095-4dannjjm 204 1 Interestingly interestingly RB cord-023095-4dannjjm 204 2 , , , cord-023095-4dannjjm 204 3 a a DT cord-023095-4dannjjm 204 4 significant significant JJ cord-023095-4dannjjm 204 5 reduction reduction NN cord-023095-4dannjjm 204 6 of of IN cord-023095-4dannjjm 204 7 myocardial myocardial JJ cord-023095-4dannjjm 204 8 leptin leptin NN cord-023095-4dannjjm 204 9 was be VBD cord-023095-4dannjjm 204 10 present present JJ cord-023095-4dannjjm 204 11 in in IN cord-023095-4dannjjm 204 12 dogs dog NNS cord-023095-4dannjjm 204 13 with with IN cord-023095-4dannjjm 204 14 congenital congenital JJ cord-023095-4dannjjm 204 15 cardiac cardiac JJ cord-023095-4dannjjm 204 16 diseases disease NNS cord-023095-4dannjjm 204 17 ( ( -LRB- cord-023095-4dannjjm 204 18 p p NN cord-023095-4dannjjm 204 19 5 5 CD cord-023095-4dannjjm 204 20 0.016 0.016 CD cord-023095-4dannjjm 204 21 ) ) -RRB- cord-023095-4dannjjm 204 22 , , , cord-023095-4dannjjm 204 23 whereas whereas IN cord-023095-4dannjjm 204 24 acquired acquire VBN cord-023095-4dannjjm 204 25 cardiac cardiac JJ cord-023095-4dannjjm 204 26 diseases disease NNS cord-023095-4dannjjm 204 27 resulted result VBD cord-023095-4dannjjm 204 28 in in IN cord-023095-4dannjjm 204 29 an an DT cord-023095-4dannjjm 204 30 increase increase NN cord-023095-4dannjjm 204 31 in in IN cord-023095-4dannjjm 204 32 leptin leptin NN cord-023095-4dannjjm 204 33 ( ( -LRB- cord-023095-4dannjjm 204 34 p p NN cord-023095-4dannjjm 204 35 5 5 CD cord-023095-4dannjjm 204 36 0.035 0.035 CD cord-023095-4dannjjm 204 37 ) ) -RRB- cord-023095-4dannjjm 204 38 in in IN cord-023095-4dannjjm 204 39 comparison comparison NN cord-023095-4dannjjm 204 40 to to IN cord-023095-4dannjjm 204 41 controls control NNS cord-023095-4dannjjm 204 42 . . . cord-023095-4dannjjm 205 1 These these DT cord-023095-4dannjjm 205 2 results result NNS cord-023095-4dannjjm 205 3 suggest suggest VBP cord-023095-4dannjjm 205 4 that that IN cord-023095-4dannjjm 205 5 the the DT cord-023095-4dannjjm 205 6 heart heart NN cord-023095-4dannjjm 205 7 might may MD cord-023095-4dannjjm 205 8 be be VB cord-023095-4dannjjm 205 9 a a DT cord-023095-4dannjjm 205 10 target target NN cord-023095-4dannjjm 205 11 of of IN cord-023095-4dannjjm 205 12 leptin leptin NN cord-023095-4dannjjm 205 13 action action NN cord-023095-4dannjjm 205 14 in in IN cord-023095-4dannjjm 205 15 the the DT cord-023095-4dannjjm 205 16 dog dog NN cord-023095-4dannjjm 205 17 and and CC cord-023095-4dannjjm 205 18 myocardial myocardial JJ cord-023095-4dannjjm 205 19 leptin leptin NN cord-023095-4dannjjm 205 20 production production NN cord-023095-4dannjjm 205 21 might may MD cord-023095-4dannjjm 205 22 play play VB cord-023095-4dannjjm 205 23 a a DT cord-023095-4dannjjm 205 24 role role NN cord-023095-4dannjjm 205 25 in in IN cord-023095-4dannjjm 205 26 regulating regulate VBG cord-023095-4dannjjm 205 27 cardiac cardiac JJ cord-023095-4dannjjm 205 28 function function NN cord-023095-4dannjjm 205 29 in in IN cord-023095-4dannjjm 205 30 an an DT cord-023095-4dannjjm 205 31 auto auto NN cord-023095-4dannjjm 205 32 - - HYPH cord-023095-4dannjjm 205 33 and and CC cord-023095-4dannjjm 205 34 paracrine paracrine JJ cord-023095-4dannjjm 205 35 manner manner NN cord-023095-4dannjjm 205 36 . . . cord-023095-4dannjjm 206 1 Predicting predict VBG cord-023095-4dannjjm 206 2 risk risk NN cord-023095-4dannjjm 206 3 of of IN cord-023095-4dannjjm 206 4 CHF CHF NNP cord-023095-4dannjjm 206 5 in in IN cord-023095-4dannjjm 206 6 asymptomatic asymptomatic JJ cord-023095-4dannjjm 206 7 dogs dog NNS cord-023095-4dannjjm 206 8 with with IN cord-023095-4dannjjm 206 9 mitral mitral JJ cord-023095-4dannjjm 206 10 valve valve NN cord-023095-4dannjjm 206 11 disease disease NN cord-023095-4dannjjm 206 12 ( ( -LRB- cord-023095-4dannjjm 206 13 MVD MVD NNP cord-023095-4dannjjm 206 14 ) ) -RRB- cord-023095-4dannjjm 206 15 is be VBZ cord-023095-4dannjjm 206 16 challenging challenging JJ cord-023095-4dannjjm 206 17 . . . cord-023095-4dannjjm 207 1 We -PRON- PRP cord-023095-4dannjjm 207 2 examined examine VBD cord-023095-4dannjjm 207 3 ability ability NN cord-023095-4dannjjm 207 4 of of IN cord-023095-4dannjjm 207 5 NT NT NNP cord-023095-4dannjjm 207 6 - - HYPH cord-023095-4dannjjm 207 7 proBNP probnp NN cord-023095-4dannjjm 207 8 to to TO cord-023095-4dannjjm 207 9 identify identify VB cord-023095-4dannjjm 207 10 asymptomatic asymptomatic JJ cord-023095-4dannjjm 207 11 dogs dog NNS cord-023095-4dannjjm 207 12 at at IN cord-023095-4dannjjm 207 13 high high JJ cord-023095-4dannjjm 207 14 risk risk NN cord-023095-4dannjjm 207 15 for for IN cord-023095-4dannjjm 207 16 CHF CHF NNP cord-023095-4dannjjm 207 17 . . . cord-023095-4dannjjm 208 1 Dogs dog NNS cord-023095-4dannjjm 208 2 with with IN cord-023095-4dannjjm 208 3 ISACHC-1b ISACHC-1b NNP cord-023095-4dannjjm 209 1 ( ( -LRB- cord-023095-4dannjjm 209 2 LA LA NNP cord-023095-4dannjjm 209 3 : : : cord-023095-4dannjjm 209 4 Ao Ao NNP cord-023095-4dannjjm 209 5 4 4 CD cord-023095-4dannjjm 209 6 1.6 1.6 CD cord-023095-4dannjjm 209 7 ) ) -RRB- cord-023095-4dannjjm 209 8 were be VBD cord-023095-4dannjjm 209 9 prospectively prospectively RB cord-023095-4dannjjm 209 10 recruited recruit VBN cord-023095-4dannjjm 209 11 ; ; : cord-023095-4dannjjm 209 12 dogs dog NNS cord-023095-4dannjjm 209 13 with with IN cord-023095-4dannjjm 209 14 current current JJ cord-023095-4dannjjm 209 15 or or CC cord-023095-4dannjjm 209 16 previous previous JJ cord-023095-4dannjjm 209 17 CHF CHF NNP cord-023095-4dannjjm 209 18 or or CC cord-023095-4dannjjm 209 19 diuretic diuretic JJ cord-023095-4dannjjm 209 20 therapy therapy NN cord-023095-4dannjjm 209 21 were be VBD cord-023095-4dannjjm 209 22 excluded exclude VBN cord-023095-4dannjjm 209 23 . . . cord-023095-4dannjjm 210 1 Physical physical JJ cord-023095-4dannjjm 210 2 examination examination NN cord-023095-4dannjjm 210 3 , , , cord-023095-4dannjjm 210 4 radiography radiography NN cord-023095-4dannjjm 210 5 , , , cord-023095-4dannjjm 210 6 echocardiography echocardiography NN cord-023095-4dannjjm 210 7 , , , cord-023095-4dannjjm 210 8 and and CC cord-023095-4dannjjm 210 9 NT NT NNP cord-023095-4dannjjm 210 10 - - HYPH cord-023095-4dannjjm 210 11 proBNP proBNP NNP cord-023095-4dannjjm 210 12 were be VBD cord-023095-4dannjjm 210 13 performed perform VBN cord-023095-4dannjjm 210 14 at at IN cord-023095-4dannjjm 210 15 2 2 CD cord-023095-4dannjjm 210 16 - - SYM cord-023095-4dannjjm 210 17 9 9 CD cord-023095-4dannjjm 210 18 mo mo NN cord-023095-4dannjjm 210 19 intervals interval NNS cord-023095-4dannjjm 210 20 for for IN cord-023095-4dannjjm 210 21 66 66 CD cord-023095-4dannjjm 210 22 dogs dog NNS cord-023095-4dannjjm 210 23 ( ( -LRB- cord-023095-4dannjjm 210 24 median median JJ cord-023095-4dannjjm 210 25 follow follow NN cord-023095-4dannjjm 210 26 - - HYPH cord-023095-4dannjjm 210 27 up up NN cord-023095-4dannjjm 210 28 5 5 CD cord-023095-4dannjjm 210 29 276 276 CD cord-023095-4dannjjm 210 30 d d NN cord-023095-4dannjjm 210 31 , , , cord-023095-4dannjjm 210 32 range range NN cord-023095-4dannjjm 210 33 , , , cord-023095-4dannjjm 210 34 17 17 CD cord-023095-4dannjjm 210 35 - - SYM cord-023095-4dannjjm 210 36 1334 1334 CD cord-023095-4dannjjm 210 37 d d NN cord-023095-4dannjjm 210 38 ) ) -RRB- cord-023095-4dannjjm 210 39 . . . cord-023095-4dannjjm 211 1 Thirty thirty CD cord-023095-4dannjjm 211 2 - - HYPH cord-023095-4dannjjm 211 3 one one CD cord-023095-4dannjjm 211 4 patients patient NNS cord-023095-4dannjjm 211 5 reached reach VBD cord-023095-4dannjjm 211 6 a a DT cord-023095-4dannjjm 211 7 study study NN cord-023095-4dannjjm 211 8 endpoint endpoint NN cord-023095-4dannjjm 211 9 of of IN cord-023095-4dannjjm 211 10 radiographic radiographic JJ cord-023095-4dannjjm 211 11 pulmonary pulmonary JJ cord-023095-4dannjjm 211 12 edema edema NN cord-023095-4dannjjm 211 13 ; ; : cord-023095-4dannjjm 211 14 35 35 CD cord-023095-4dannjjm 211 15 remained remain VBD cord-023095-4dannjjm 211 16 asymptomatic asymptomatic JJ cord-023095-4dannjjm 211 17 . . . cord-023095-4dannjjm 212 1 Parameters parameter NNS cord-023095-4dannjjm 212 2 from from IN cord-023095-4dannjjm 212 3 the the DT cord-023095-4dannjjm 212 4 visit visit NN cord-023095-4dannjjm 212 5 immediately immediately RB cord-023095-4dannjjm 212 6 previous previous JJ cord-023095-4dannjjm 212 7 to to IN cord-023095-4dannjjm 212 8 onset onset NN cord-023095-4dannjjm 212 9 of of IN cord-023095-4dannjjm 212 10 CHF CHF NNP cord-023095-4dannjjm 212 11 ( ( -LRB- cord-023095-4dannjjm 212 12 Future Future NNP cord-023095-4dannjjm 212 13 - - HYPH cord-023095-4dannjjm 212 14 CHF CHF NNP cord-023095-4dannjjm 212 15 ) ) -RRB- cord-023095-4dannjjm 212 16 or or CC cord-023095-4dannjjm 212 17 prior prior RB cord-023095-4dannjjm 212 18 to to IN cord-023095-4dannjjm 212 19 the the DT cord-023095-4dannjjm 212 20 most most RBS cord-023095-4dannjjm 212 21 recent recent JJ cord-023095-4dannjjm 212 22 visit visit NN cord-023095-4dannjjm 212 23 without without IN cord-023095-4dannjjm 212 24 CHF CHF NNP cord-023095-4dannjjm 212 25 ( ( -LRB- cord-023095-4dannjjm 212 26 Remain Remain NNP cord-023095-4dannjjm 212 27 - - HYPH cord-023095-4dannjjm 212 28 Asympt Asympt NNP cord-023095-4dannjjm 212 29 ) ) -RRB- cord-023095-4dannjjm 212 30 were be VBD cord-023095-4dannjjm 212 31 analyzed analyze VBN cord-023095-4dannjjm 212 32 . . . cord-023095-4dannjjm 213 1 Median median JJ cord-023095-4dannjjm 213 2 NT NT NNP cord-023095-4dannjjm 213 3 - - HYPH cord-023095-4dannjjm 213 4 proBNP probnp NN cord-023095-4dannjjm 213 5 of of IN cord-023095-4dannjjm 213 6 Future Future NNP cord-023095-4dannjjm 213 7 - - HYPH cord-023095-4dannjjm 213 8 CHF CHF NNP cord-023095-4dannjjm 214 1 ( ( -LRB- cord-023095-4dannjjm 214 2 3001pmol 3001pmol NNP cord-023095-4dannjjm 214 3 / / SYM cord-023095-4dannjjm 214 4 Lpmol Lpmol NNP cord-023095-4dannjjm 214 5 / / SYM cord-023095-4dannjjm 214 6 L L NNP cord-023095-4dannjjm 214 7 , , , cord-023095-4dannjjm 214 8 IQR IQR NNP cord-023095-4dannjjm 214 9 2255 2255 CD cord-023095-4dannjjm 214 10 - - HYPH cord-023095-4dannjjm 214 11 3001 3001 CD cord-023095-4dannjjm 214 12 ) ) -RRB- cord-023095-4dannjjm 214 13 was be VBD cord-023095-4dannjjm 214 14 significantly significantly RB cord-023095-4dannjjm 214 15 different different JJ cord-023095-4dannjjm 214 16 from from IN cord-023095-4dannjjm 214 17 Remain Remain NNP cord-023095-4dannjjm 214 18 - - HYPH cord-023095-4dannjjm 214 19 Asympt Asympt NNP cord-023095-4dannjjm 214 20 ( ( -LRB- cord-023095-4dannjjm 214 21 1600 1600 CD cord-023095-4dannjjm 214 22 pmol pmol NNP cord-023095-4dannjjm 214 23 / / SYM cord-023095-4dannjjm 214 24 L L NNP cord-023095-4dannjjm 214 25 , , , cord-023095-4dannjjm 214 26 984 984 CD cord-023095-4dannjjm 214 27 - - HYPH cord-023095-4dannjjm 214 28 2863 2863 CD cord-023095-4dannjjm 214 29 ; ; : cord-023095-4dannjjm 214 30 P p NN cord-023095-4dannjjm 214 31 5 5 CD cord-023095-4dannjjm 214 32 0.0004 0.0004 CD cord-023095-4dannjjm 214 33 ) ) -RRB- cord-023095-4dannjjm 214 34 . . . cord-023095-4dannjjm 215 1 Median median JJ cord-023095-4dannjjm 215 2 time time NN cord-023095-4dannjjm 215 3 to to IN cord-023095-4dannjjm 215 4 CHF CHF NNP cord-023095-4dannjjm 215 5 of of IN cord-023095-4dannjjm 215 6 Future Future NNP cord-023095-4dannjjm 215 7 - - HYPH cord-023095-4dannjjm 215 8 CHF CHF NNP cord-023095-4dannjjm 215 9 was be VBD cord-023095-4dannjjm 215 10 86d 86d . cord-023095-4dannjjm 216 1 ( ( -LRB- cord-023095-4dannjjm 216 2 IQR IQR NNP cord-023095-4dannjjm 216 3 , , , cord-023095-4dannjjm 216 4 . . . cord-023095-4dannjjm 217 1 Groups group NNS cord-023095-4dannjjm 217 2 also also RB cord-023095-4dannjjm 217 3 differed differ VBD cord-023095-4dannjjm 217 4 in in IN cord-023095-4dannjjm 217 5 median median JJ cord-023095-4dannjjm 217 6 LA LA NNP cord-023095-4dannjjm 217 7 : : : cord-023095-4dannjjm 217 8 Ao Ao NNP cord-023095-4dannjjm 217 9 ( ( -LRB- cord-023095-4dannjjm 217 10 Future Future NNP cord-023095-4dannjjm 217 11 - - HYPH cord-023095-4dannjjm 217 12 CHF CHF NNP cord-023095-4dannjjm 217 13 2.20 2.20 CD cord-023095-4dannjjm 217 14 [ [ -LRB- cord-023095-4dannjjm 217 15 2.00 2.00 CD cord-023095-4dannjjm 217 16 - - SYM cord-023095-4dannjjm 217 17 2.50 2.50 CD cord-023095-4dannjjm 217 18 ] ] -RRB- cord-023095-4dannjjm 217 19 ; ; : cord-023095-4dannjjm 217 20 Remain remain VB cord-023095-4dannjjm 217 21 - - HYPH cord-023095-4dannjjm 217 22 Asympt Asympt NNP cord-023095-4dannjjm 217 23 1.96 1.96 CD cord-023095-4dannjjm 217 24 [ [ -LRB- cord-023095-4dannjjm 217 25 1.85 1.85 CD cord-023095-4dannjjm 217 26 - - SYM cord-023095-4dannjjm 217 27 2.13 2.13 CD cord-023095-4dannjjm 217 28 ] ] -RRB- cord-023095-4dannjjm 217 29 , , , cord-023095-4dannjjm 217 30 P p NN cord-023095-4dannjjm 217 31 5 5 CD cord-023095-4dannjjm 217 32 0.0014 0.0014 CD cord-023095-4dannjjm 217 33 ) ) -RRB- cord-023095-4dannjjm 217 34 ; ; : cord-023095-4dannjjm 217 35 VHS VHS NNP cord-023095-4dannjjm 217 36 ( ( -LRB- cord-023095-4dannjjm 217 37 Future- Future- NNP cord-023095-4dannjjm 217 38 ] ] -RRB- cord-023095-4dannjjm 217 39 ; ; : cord-023095-4dannjjm 217 40 Remain remain VB cord-023095-4dannjjm 217 41 - - HYPH cord-023095-4dannjjm 217 42 Asympt Asympt NNP cord-023095-4dannjjm 217 43 11.3 11.3 CD cord-023095-4dannjjm 217 44 [ [ -LRB- cord-023095-4dannjjm 217 45 10.75 10.75 CD cord-023095-4dannjjm 217 46 - - SYM cord-023095-4dannjjm 217 47 12.0 12.0 CD cord-023095-4dannjjm 217 48 ] ] -RRB- cord-023095-4dannjjm 217 49 , , , cord-023095-4dannjjm 217 50 P p NN cord-023095-4dannjjm 217 51 5 5 CD cord-023095-4dannjjm 217 52 0.003 0.003 CD cord-023095-4dannjjm 217 53 ) ) -RRB- cord-023095-4dannjjm 217 54 ; ; : cord-023095-4dannjjm 217 55 and and CC cord-023095-4dannjjm 217 56 LVIDd LVIDd NNS cord-023095-4dannjjm 217 57 : : : cord-023095-4dannjjm 217 58 Ao Ao NNP cord-023095-4dannjjm 217 59 ] ] -RRB- cord-023095-4dannjjm 217 60 ; ; : cord-023095-4dannjjm 217 61 Remain remain VB cord-023095-4dannjjm 217 62 - - HYPH cord-023095-4dannjjm 217 63 Asympt Asympt NNP cord-023095-4dannjjm 217 64 2.33 2.33 CD cord-023095-4dannjjm 218 1 [ [ -LRB- cord-023095-4dannjjm 218 2 2.15 2.15 CD cord-023095-4dannjjm 218 3 - - SYM cord-023095-4dannjjm 218 4 2.64 2.64 CD cord-023095-4dannjjm 218 5 ] ] -RRB- cord-023095-4dannjjm 218 6 , , , cord-023095-4dannjjm 218 7 P p NN cord-023095-4dannjjm 218 8 5 5 CD cord-023095-4dannjjm 218 9 0.0001 0.0001 CD cord-023095-4dannjjm 218 10 ) ) -RRB- cord-023095-4dannjjm 218 11 . . . cord-023095-4dannjjm 219 1 ROC ROC NNP cord-023095-4dannjjm 219 2 analysis analysis NN cord-023095-4dannjjm 219 3 to to TO cord-023095-4dannjjm 219 4 predict predict VB cord-023095-4dannjjm 219 5 if if IN cord-023095-4dannjjm 219 6 CHF CHF NNP cord-023095-4dannjjm 219 7 would would MD cord-023095-4dannjjm 219 8 occur occur VB cord-023095-4dannjjm 219 9 prior prior RB cord-023095-4dannjjm 219 10 to to IN cord-023095-4dannjjm 219 11 the the DT cord-023095-4dannjjm 219 12 next next JJ cord-023095-4dannjjm 219 13 visit visit NN cord-023095-4dannjjm 219 14 yielded yield VBD cord-023095-4dannjjm 219 15 AUC AUC NNP cord-023095-4dannjjm 219 16 5 5 CD cord-023095-4dannjjm 219 17 0.753 0.753 CD cord-023095-4dannjjm 219 18 ( ( -LRB- cord-023095-4dannjjm 219 19 95%CI 95%ci CD cord-023095-4dannjjm 219 20 , , , cord-023095-4dannjjm 219 21 0.632 0.632 CD cord-023095-4dannjjm 219 22 - - SYM cord-023095-4dannjjm 219 23 0.851 0.851 CD cord-023095-4dannjjm 219 24 ) ) -RRB- cord-023095-4dannjjm 219 25 . . . cord-023095-4dannjjm 220 1 Sensitivity sensitivity NN cord-023095-4dannjjm 220 2 was be VBD cord-023095-4dannjjm 220 3 90.3 90.3 CD cord-023095-4dannjjm 220 4 % % NN cord-023095-4dannjjm 220 5 or or CC cord-023095-4dannjjm 220 6 77.4 77.4 CD cord-023095-4dannjjm 220 7 % % NN cord-023095-4dannjjm 220 8 and and CC cord-023095-4dannjjm 220 9 specificity specificity NN cord-023095-4dannjjm 220 10 48.6 48.6 CD cord-023095-4dannjjm 220 11 % % NN cord-023095-4dannjjm 220 12 or or CC cord-023095-4dannjjm 220 13 68.6 68.6 CD cord-023095-4dannjjm 220 14 % % NN cord-023095-4dannjjm 220 15 for for IN cord-023095-4dannjjm 220 16 NT NT NNP cord-023095-4dannjjm 220 17 - - HYPH cord-023095-4dannjjm 220 18 proBNP proBNP NNP cord-023095-4dannjjm 220 19 41490 41490 CD cord-023095-4dannjjm 220 20 pmol pmol NNP cord-023095-4dannjjm 220 21 / / SYM cord-023095-4dannjjm 220 22 L l NN cord-023095-4dannjjm 220 23 or or CC cord-023095-4dannjjm 220 24 42150 42150 CD cord-023095-4dannjjm 220 25 pmol pmol NNP cord-023095-4dannjjm 220 26 / / SYM cord-023095-4dannjjm 220 27 L L NNP cord-023095-4dannjjm 220 28 , , , cord-023095-4dannjjm 220 29 respectively respectively RB cord-023095-4dannjjm 220 30 . . . cord-023095-4dannjjm 221 1 Mean mean JJ cord-023095-4dannjjm 221 2 increase increase NN cord-023095-4dannjjm 221 3 in in IN cord-023095-4dannjjm 221 4 NT NT NNP cord-023095-4dannjjm 221 5 - - HYPH cord-023095-4dannjjm 221 6 proBNP probnp NN cord-023095-4dannjjm 221 7 between between IN cord-023095-4dannjjm 221 8 penultimate penultimate JJ cord-023095-4dannjjm 221 9 visit visit NN cord-023095-4dannjjm 221 10 and and CC cord-023095-4dannjjm 221 11 two two CD cord-023095-4dannjjm 221 12 visits visit NNS cord-023095-4dannjjm 221 13 prior prior RB cord-023095-4dannjjm 221 14 to to IN cord-023095-4dannjjm 221 15 endpoint endpoint NN cord-023095-4dannjjm 221 16 : : : cord-023095-4dannjjm 221 17 Future future JJ cord-023095-4dannjjm 221 18 - - HYPH cord-023095-4dannjjm 221 19 CHF CHF NNP cord-023095-4dannjjm 221 20 5 5 CD cord-023095-4dannjjm 221 21 1440.1 1440.1 CD cord-023095-4dannjjm 221 22 pmol pmol NNP cord-023095-4dannjjm 221 23 / / SYM cord-023095-4dannjjm 221 24 L l NN cord-023095-4dannjjm 221 25 vs. vs. FW cord-023095-4dannjjm 221 26 Remain Remain NNP cord-023095-4dannjjm 221 27 - - HYPH cord-023095-4dannjjm 221 28 Asympt Asympt NNP cord-023095-4dannjjm 221 29 5 5 CD cord-023095-4dannjjm 222 1 110.5 110.5 CD cord-023095-4dannjjm 222 2 pmol pmol NNP cord-023095-4dannjjm 223 1 /L. /L. . cord-023095-4dannjjm 224 1 Within within IN cord-023095-4dannjjm 224 2 6 6 CD cord-023095-4dannjjm 224 3 mo mo NN cord-023095-4dannjjm 224 4 , , , cord-023095-4dannjjm 224 5 4.5 4.5 CD cord-023095-4dannjjm 224 6 % % NN cord-023095-4dannjjm 224 7 , , , cord-023095-4dannjjm 224 8 10.7 10.7 CD cord-023095-4dannjjm 224 9 % % NN cord-023095-4dannjjm 224 10 , , , cord-023095-4dannjjm 224 11 17.4 17.4 CD cord-023095-4dannjjm 224 12 % % NN cord-023095-4dannjjm 224 13 , , , cord-023095-4dannjjm 224 14 and and CC cord-023095-4dannjjm 224 15 36.7 36.7 CD cord-023095-4dannjjm 224 16 % % NN cord-023095-4dannjjm 224 17 of of IN cord-023095-4dannjjm 224 18 dogs dog NNS cord-023095-4dannjjm 224 19 with with IN cord-023095-4dannjjm 224 20 NT NT NNP cord-023095-4dannjjm 224 21 - - HYPH cord-023095-4dannjjm 224 22 proBNP probnp NN cord-023095-4dannjjm 224 23 o o NN cord-023095-4dannjjm 224 24 1000 1000 CD cord-023095-4dannjjm 224 25 , , , cord-023095-4dannjjm 224 26 , , , cord-023095-4dannjjm 224 27 and and CC cord-023095-4dannjjm 224 28 43000 43000 CD cord-023095-4dannjjm 224 29 pmol pmol NNP cord-023095-4dannjjm 224 30 / / SYM cord-023095-4dannjjm 224 31 L L NNP cord-023095-4dannjjm 224 32 developed develop VBD cord-023095-4dannjjm 224 33 CHF CHF NNP cord-023095-4dannjjm 224 34 . . . cord-023095-4dannjjm 225 1 NT NT NNP cord-023095-4dannjjm 225 2 - - HYPH cord-023095-4dannjjm 225 3 proBNP probnp NN cord-023095-4dannjjm 225 4 and and CC cord-023095-4dannjjm 225 5 heart heart NN cord-023095-4dannjjm 225 6 size size NN cord-023095-4dannjjm 225 7 helped help VBD cord-023095-4dannjjm 225 8 assess assess VB cord-023095-4dannjjm 225 9 risk risk NN cord-023095-4dannjjm 225 10 of of IN cord-023095-4dannjjm 225 11 CHF CHF NNP cord-023095-4dannjjm 225 12 in in IN cord-023095-4dannjjm 225 13 asymptomatic asymptomatic JJ cord-023095-4dannjjm 225 14 MVD MVD NNP cord-023095-4dannjjm 225 15 . . . cord-023095-4dannjjm 226 1 Increasing increase VBG cord-023095-4dannjjm 226 2 the the DT cord-023095-4dannjjm 226 3 assay assay NN cord-023095-4dannjjm 226 4 's 's POS cord-023095-4dannjjm 226 5 upper upper JJ cord-023095-4dannjjm 226 6 limit limit NN cord-023095-4dannjjm 226 7 of of IN cord-023095-4dannjjm 226 8 detection detection NN cord-023095-4dannjjm 226 9 would would MD cord-023095-4dannjjm 226 10 likely likely RB cord-023095-4dannjjm 226 11 improve improve VB cord-023095-4dannjjm 226 12 utility utility NN cord-023095-4dannjjm 226 13 of of IN cord-023095-4dannjjm 226 14 NT NT NNP cord-023095-4dannjjm 226 15 - - HYPH cord-023095-4dannjjm 226 16 proBNP probnp NN cord-023095-4dannjjm 226 17 . . . cord-023095-4dannjjm 227 1 PIIINP PIIINP NNP cord-023095-4dannjjm 227 2 is be VBZ cord-023095-4dannjjm 227 3 a a DT cord-023095-4dannjjm 227 4 serum serum NN cord-023095-4dannjjm 227 5 biomarker biomarker NN cord-023095-4dannjjm 227 6 of of IN cord-023095-4dannjjm 227 7 collagen collagen NN cord-023095-4dannjjm 227 8 biosynthesis biosynthesis NN cord-023095-4dannjjm 227 9 and and CC cord-023095-4dannjjm 227 10 is be VBZ cord-023095-4dannjjm 227 11 described describe VBN cord-023095-4dannjjm 227 12 as as IN cord-023095-4dannjjm 227 13 a a DT cord-023095-4dannjjm 227 14 marker marker NN cord-023095-4dannjjm 227 15 of of IN cord-023095-4dannjjm 227 16 myocardial myocardial JJ cord-023095-4dannjjm 227 17 fibrosis fibrosis NN cord-023095-4dannjjm 227 18 in in IN cord-023095-4dannjjm 227 19 human human JJ cord-023095-4dannjjm 227 20 patients patient NNS cord-023095-4dannjjm 227 21 . . . cord-023095-4dannjjm 228 1 We -PRON- PRP cord-023095-4dannjjm 228 2 hypothesised hypothesise VBD cord-023095-4dannjjm 228 3 that that IN cord-023095-4dannjjm 228 4 PIIINP PIIINP NNP cord-023095-4dannjjm 228 5 concentrations concentration NNS cord-023095-4dannjjm 228 6 would would MD cord-023095-4dannjjm 228 7 vary vary VB cord-023095-4dannjjm 228 8 according accord VBG cord-023095-4dannjjm 228 9 to to IN cord-023095-4dannjjm 228 10 the the DT cord-023095-4dannjjm 228 11 degree degree NN cord-023095-4dannjjm 228 12 of of IN cord-023095-4dannjjm 228 13 remodelling remodelle VBG cord-023095-4dannjjm 228 14 demonstrable demonstrable JJ cord-023095-4dannjjm 228 15 in in IN cord-023095-4dannjjm 228 16 dogs dog NNS cord-023095-4dannjjm 228 17 with with IN cord-023095-4dannjjm 228 18 naturallyoccurring naturallyoccurre VBG cord-023095-4dannjjm 228 19 myxomatous myxomatous JJ cord-023095-4dannjjm 228 20 mitral mitral JJ cord-023095-4dannjjm 228 21 valve valve NN cord-023095-4dannjjm 228 22 disease disease NN cord-023095-4dannjjm 228 23 ( ( -LRB- cord-023095-4dannjjm 228 24 MMVD MMVD NNP cord-023095-4dannjjm 228 25 ) ) -RRB- cord-023095-4dannjjm 228 26 . . . cord-023095-4dannjjm 229 1 Serum serum NN cord-023095-4dannjjm 229 2 PIIINP PIIINP NNP cord-023095-4dannjjm 229 3 concentrations concentration NNS cord-023095-4dannjjm 229 4 ( ( -LRB- cord-023095-4dannjjm 229 5 mg mg NNP cord-023095-4dannjjm 229 6 / / SYM cord-023095-4dannjjm 229 7 ml ml NNP cord-023095-4dannjjm 229 8 ) ) -RRB- cord-023095-4dannjjm 229 9 were be VBD cord-023095-4dannjjm 229 10 measured measure VBN cord-023095-4dannjjm 229 11 in in IN cord-023095-4dannjjm 229 12 dogs dog NNS cord-023095-4dannjjm 229 13 with with IN cord-023095-4dannjjm 229 14 MMVD MMVD NNP cord-023095-4dannjjm 229 15 and and CC cord-023095-4dannjjm 229 16 healthy healthy JJ cord-023095-4dannjjm 229 17 controls control NNS cord-023095-4dannjjm 229 18 using use VBG cord-023095-4dannjjm 229 19 a a DT cord-023095-4dannjjm 229 20 validated validate VBN cord-023095-4dannjjm 229 21 commerciallyavailable commerciallyavailable NN cord-023095-4dannjjm 229 22 radioimmunoassay radioimmunoassay NN cord-023095-4dannjjm 229 23 . . . cord-023095-4dannjjm 230 1 Results result NNS cord-023095-4dannjjm 230 2 are be VBP cord-023095-4dannjjm 230 3 reported report VBN cord-023095-4dannjjm 230 4 as as IN cord-023095-4dannjjm 230 5 ( ( -LRB- cord-023095-4dannjjm 230 6 Mean mean JJ cord-023095-4dannjjm 230 7 AE AE NNP cord-023095-4dannjjm 230 8 SD SD NNP cord-023095-4dannjjm 230 9 ) ) -RRB- cord-023095-4dannjjm 230 10 . . . cord-023095-4dannjjm 231 1 Non Non NNS cord-023095-4dannjjm 231 2 - - JJ cord-023095-4dannjjm 231 3 normally normally RB cord-023095-4dannjjm 231 4 distributed distribute VBN cord-023095-4dannjjm 231 5 variables variable NNS cord-023095-4dannjjm 231 6 were be VBD cord-023095-4dannjjm 231 7 logarithmically logarithmically RB cord-023095-4dannjjm 231 8 transformed transform VBN cord-023095-4dannjjm 231 9 . . . cord-023095-4dannjjm 232 1 Comparisons comparison NNS cord-023095-4dannjjm 232 2 of of IN cord-023095-4dannjjm 232 3 continuous continuous JJ cord-023095-4dannjjm 232 4 variables variable NNS cord-023095-4dannjjm 232 5 were be VBD cord-023095-4dannjjm 232 6 made make VBN cord-023095-4dannjjm 232 7 between between IN cord-023095-4dannjjm 232 8 groups group NNS cord-023095-4dannjjm 232 9 using use VBG cord-023095-4dannjjm 232 10 t t NN cord-023095-4dannjjm 232 11 - - HYPH cord-023095-4dannjjm 232 12 tests test NNS cord-023095-4dannjjm 232 13 and and CC cord-023095-4dannjjm 232 14 one one CD cord-023095-4dannjjm 232 15 - - HYPH cord-023095-4dannjjm 232 16 way way NN cord-023095-4dannjjm 232 17 ANOVAs anova NNS cord-023095-4dannjjm 232 18 with with IN cord-023095-4dannjjm 232 19 Tukey Tukey NNP cord-023095-4dannjjm 232 20 's 's POS cord-023095-4dannjjm 232 21 post post JJ cord-023095-4dannjjm 232 22 - - JJ cord-023095-4dannjjm 232 23 hoc hoc JJ cord-023095-4dannjjm 232 24 comparisons comparison NNS cord-023095-4dannjjm 232 25 . . . cord-023095-4dannjjm 233 1 Univariable univariable JJ cord-023095-4dannjjm 233 2 analyses analysis NNS cord-023095-4dannjjm 233 3 were be VBD cord-023095-4dannjjm 233 4 used use VBN cord-023095-4dannjjm 233 5 to to TO cord-023095-4dannjjm 233 6 evaluate evaluate VB cord-023095-4dannjjm 233 7 associations association NNS cord-023095-4dannjjm 233 8 between between IN cord-023095-4dannjjm 233 9 PIIINP PIIINP NNP cord-023095-4dannjjm 233 10 and and CC cord-023095-4dannjjm 233 11 clinical clinical JJ cord-023095-4dannjjm 233 12 characteristics characteristic NNS cord-023095-4dannjjm 233 13 ( ( -LRB- cord-023095-4dannjjm 233 14 age age NN cord-023095-4dannjjm 233 15 , , , cord-023095-4dannjjm 233 16 breed breed VB cord-023095-4dannjjm 233 17 [ [ -LRB- cord-023095-4dannjjm 233 18 cavalier cavalier JJ cord-023095-4dannjjm 233 19 King King NNP cord-023095-4dannjjm 233 20 Charles Charles NNP cord-023095-4dannjjm 233 21 spaniel spaniel NN cord-023095-4dannjjm 233 22 ( ( -LRB- cord-023095-4dannjjm 233 23 CKCS CKCS NNP cord-023095-4dannjjm 233 24 ) ) -RRB- cord-023095-4dannjjm 233 25 yes/ yes/ NNP cord-023095-4dannjjm 233 26 no no NN cord-023095-4dannjjm 233 27 ] ] -RRB- cord-023095-4dannjjm 233 28 , , , cord-023095-4dannjjm 233 29 sex sex NN cord-023095-4dannjjm 233 30 , , , cord-023095-4dannjjm 233 31 weight weight NN cord-023095-4dannjjm 233 32 , , , cord-023095-4dannjjm 233 33 heart heart NN cord-023095-4dannjjm 233 34 rate rate NN cord-023095-4dannjjm 233 35 [ [ -LRB- cord-023095-4dannjjm 233 36 measured measure VBN cord-023095-4dannjjm 233 37 from from IN cord-023095-4dannjjm 233 38 ECG ECG NNP cord-023095-4dannjjm 233 39 ] ] -RRB- cord-023095-4dannjjm 233 40 , , , cord-023095-4dannjjm 233 41 treatment treatment NN cord-023095-4dannjjm 233 42 with with IN cord-023095-4dannjjm 233 43 ACEi ACEi NNS cord-023095-4dannjjm 233 44 [ [ -LRB- cord-023095-4dannjjm 233 45 yes/ yes/ NNP cord-023095-4dannjjm 233 46 no no NN cord-023095-4dannjjm 233 47 ] ] -RRB- cord-023095-4dannjjm 233 48 , , , cord-023095-4dannjjm 233 49 treatment treatment NN cord-023095-4dannjjm 233 50 with with IN cord-023095-4dannjjm 233 51 diuretics diuretic NNS cord-023095-4dannjjm 233 52 [ [ -LRB- cord-023095-4dannjjm 233 53 yes/ yes/ NNP cord-023095-4dannjjm 233 54 no no NN cord-023095-4dannjjm 233 55 ] ] -RRB- cord-023095-4dannjjm 233 56 and and CC cord-023095-4dannjjm 233 57 echocardiographic echocardiographic JJ cord-023095-4dannjjm 233 58 measurements measurement NNS cord-023095-4dannjjm 234 1 [ [ -LRB- cord-023095-4dannjjm 234 2 LA LA NNP cord-023095-4dannjjm 234 3 / / SYM cord-023095-4dannjjm 234 4 Ao Ao NNP cord-023095-4dannjjm 234 5 , , , cord-023095-4dannjjm 234 6 LVEDD/ LVEDD/ NNP cord-023095-4dannjjm 234 7 LVFWd LVFWd NNS cord-023095-4dannjjm 234 8 , , , cord-023095-4dannjjm 234 9 LVEDDN LVEDDN NNP cord-023095-4dannjjm 234 10 , , , cord-023095-4dannjjm 234 11 LVESDN LVESDN NNP cord-023095-4dannjjm 234 12 ] ] -RRB- cord-023095-4dannjjm 234 13 ) ) -RRB- cord-023095-4dannjjm 234 14 . . . cord-023095-4dannjjm 235 1 Multivariable multivariable JJ cord-023095-4dannjjm 235 2 analysis analysis NN cord-023095-4dannjjm 235 3 was be VBD cord-023095-4dannjjm 235 4 initially initially RB cord-023095-4dannjjm 235 5 performed perform VBN cord-023095-4dannjjm 235 6 with with IN cord-023095-4dannjjm 235 7 all all DT cord-023095-4dannjjm 235 8 dogs dog NNS cord-023095-4dannjjm 235 9 included include VBN cord-023095-4dannjjm 235 10 and and CC cord-023095-4dannjjm 235 11 then then RB cord-023095-4dannjjm 235 12 repeated repeat VBD cord-023095-4dannjjm 235 13 excluding exclude VBG cord-023095-4dannjjm 235 14 all all DT cord-023095-4dannjjm 235 15 dogs dog NNS cord-023095-4dannjjm 235 16 receiving receive VBG cord-023095-4dannjjm 235 17 therapy therapy NN cord-023095-4dannjjm 235 18 . . . cord-023095-4dannjjm 236 1 Dogs dog NNS cord-023095-4dannjjm 236 2 with with IN cord-023095-4dannjjm 236 3 MMVD MMVD NNP cord-023095-4dannjjm 236 4 were be VBD cord-023095-4dannjjm 236 5 divided divide VBN cord-023095-4dannjjm 236 6 into into IN cord-023095-4dannjjm 236 7 those those DT cord-023095-4dannjjm 236 8 with with IN cord-023095-4dannjjm 236 9 no no DT cord-023095-4dannjjm 236 10 cardiomegaly cardiomegaly NN cord-023095-4dannjjm 236 11 ( ( -LRB- cord-023095-4dannjjm 236 12 NC NC NNP cord-023095-4dannjjm 236 13 ) ) -RRB- cord-023095-4dannjjm 237 1 ( ( -LRB- cord-023095-4dannjjm 237 2 LA LA NNP cord-023095-4dannjjm 237 3 / / SYM cord-023095-4dannjjm 237 4 Ao Ao NNP cord-023095-4dannjjm 237 5 o o NNP cord-023095-4dannjjm 237 6 1.5 1.5 CD cord-023095-4dannjjm 237 7 and and CC cord-023095-4dannjjm 237 8 LVEDDN LVEDDN NNP cord-023095-4dannjjm 237 9 o o NNP cord-023095-4dannjjm 237 10 1.8 1.8 CD cord-023095-4dannjjm 237 11 ) ) -RRB- cord-023095-4dannjjm 237 12 , , . cord-023095-4dannjjm 238 1 those those DT cord-023095-4dannjjm 238 2 with with IN cord-023095-4dannjjm 238 3 cardiomegaly cardiomegaly NN cord-023095-4dannjjm 238 4 ( ( -LRB- cord-023095-4dannjjm 238 5 LA LA NNP cord-023095-4dannjjm 238 6 / / SYM cord-023095-4dannjjm 238 7 Ao Ao NNP cord-023095-4dannjjm 238 8 ! ! . cord-023095-4dannjjm 239 1 1.5 1.5 CD cord-023095-4dannjjm 239 2 and/ and/ CD cord-023095-4dannjjm 239 3 or or CC cord-023095-4dannjjm 239 4 LVEDDN LVEDDN NNP cord-023095-4dannjjm 239 5 ! ! . cord-023095-4dannjjm 239 6 1.8 1.8 CD cord-023095-4dannjjm 239 7 ) ) -RRB- cord-023095-4dannjjm 240 1 but but CC cord-023095-4dannjjm 240 2 no no DT cord-023095-4dannjjm 240 3 clinical clinical JJ cord-023095-4dannjjm 240 4 signs sign NNS cord-023095-4dannjjm 240 5 ( ( -LRB- cord-023095-4dannjjm 240 6 C C NNP cord-023095-4dannjjm 240 7 ) ) -RRB- cord-023095-4dannjjm 240 8 and and CC cord-023095-4dannjjm 240 9 those those DT cord-023095-4dannjjm 240 10 dogs dog NNS cord-023095-4dannjjm 240 11 with with IN cord-023095-4dannjjm 240 12 cardiomegaly cardiomegaly NN cord-023095-4dannjjm 240 13 requiring require VBG cord-023095-4dannjjm 240 14 treatment treatment NN cord-023095-4dannjjm 240 15 for for IN cord-023095-4dannjjm 240 16 congestive congestive JJ cord-023095-4dannjjm 240 17 heart heart NN cord-023095-4dannjjm 240 18 failure failure NN cord-023095-4dannjjm 240 19 ( ( -LRB- cord-023095-4dannjjm 240 20 CHF CHF NNP cord-023095-4dannjjm 240 21 ) ) -RRB- cord-023095-4dannjjm 240 22 . . . cord-023095-4dannjjm 241 1 One one CD cord-023095-4dannjjm 241 2 hundred hundred CD cord-023095-4dannjjm 241 3 and and CC cord-023095-4dannjjm 241 4 fifty fifty CD cord-023095-4dannjjm 241 5 - - HYPH cord-023095-4dannjjm 241 6 four four CD cord-023095-4dannjjm 241 7 dogs dog NNS cord-023095-4dannjjm 241 8 with with IN cord-023095-4dannjjm 241 9 MMVD MMVD NNP cord-023095-4dannjjm 241 10 and and CC cord-023095-4dannjjm 241 11 23 23 CD cord-023095-4dannjjm 241 12 control control NN cord-023095-4dannjjm 241 13 dogs dog NNS cord-023095-4dannjjm 241 14 were be VBD cord-023095-4dannjjm 241 15 studied study VBN cord-023095-4dannjjm 241 16 . . . cord-023095-4dannjjm 242 1 There there EX cord-023095-4dannjjm 242 2 was be VBD cord-023095-4dannjjm 242 3 no no DT cord-023095-4dannjjm 242 4 difference difference NN cord-023095-4dannjjm 242 5 in in IN cord-023095-4dannjjm 242 6 age age NN cord-023095-4dannjjm 242 7 ( ( -LRB- cord-023095-4dannjjm 242 8 P p NN cord-023095-4dannjjm 242 9 5 5 CD cord-023095-4dannjjm 242 10 0.870 0.870 CD cord-023095-4dannjjm 242 11 ) ) -RRB- cord-023095-4dannjjm 242 12 or or CC cord-023095-4dannjjm 242 13 weight weight NN cord-023095-4dannjjm 242 14 ( ( -LRB- cord-023095-4dannjjm 242 15 P p NN cord-023095-4dannjjm 242 16 5 5 CD cord-023095-4dannjjm 242 17 0.606 0.606 CD cord-023095-4dannjjm 242 18 ) ) -RRB- cord-023095-4dannjjm 242 19 between between IN cord-023095-4dannjjm 242 20 the the DT cord-023095-4dannjjm 242 21 MMVD MMVD NNP cord-023095-4dannjjm 242 22 and and CC cord-023095-4dannjjm 242 23 control control NN cord-023095-4dannjjm 242 24 groups group NNS cord-023095-4dannjjm 242 25 . . . cord-023095-4dannjjm 243 1 There there EX cord-023095-4dannjjm 243 2 was be VBD cord-023095-4dannjjm 243 3 a a DT cord-023095-4dannjjm 243 4 significant significant JJ cord-023095-4dannjjm 243 5 difference difference NN cord-023095-4dannjjm 243 6 in in IN cord-023095-4dannjjm 243 7 serum serum NN cord-023095-4dannjjm 243 8 PIIINP PIIINP NNP cord-023095-4dannjjm 243 9 ( ( -LRB- cord-023095-4dannjjm 243 10 P p NN cord-023095-4dannjjm 243 11 5 5 CD cord-023095-4dannjjm 243 12 0.034 0.034 CD cord-023095-4dannjjm 243 13 ) ) -RRB- cord-023095-4dannjjm 243 14 between between IN cord-023095-4dannjjm 243 15 normal normal JJ cord-023095-4dannjjm 243 16 ( ( -LRB- cord-023095-4dannjjm 243 17 11.2 11.2 CD cord-023095-4dannjjm 243 18 AE AE NNP cord-023095-4dannjjm 243 19 3.66 3.66 CD cord-023095-4dannjjm 243 20 ) ) -RRB- cord-023095-4dannjjm 243 21 , , , cord-023095-4dannjjm 243 22 NC NC NNP cord-023095-4dannjjm 243 23 ( ( -LRB- cord-023095-4dannjjm 243 24 11.6 11.6 CD cord-023095-4dannjjm 243 25 AE AE NNP cord-023095-4dannjjm 243 26 4.57 4.57 CD cord-023095-4dannjjm 243 27 ) ) -RRB- cord-023095-4dannjjm 243 28 , , , cord-023095-4dannjjm 243 29 C C NNP cord-023095-4dannjjm 243 30 ( ( -LRB- cord-023095-4dannjjm 243 31 10.1 10.1 CD cord-023095-4dannjjm 243 32 AE AE NNP cord-023095-4dannjjm 243 33 3.44 3.44 CD cord-023095-4dannjjm 243 34 ) ) -RRB- cord-023095-4dannjjm 243 35 and and CC cord-023095-4dannjjm 243 36 CHF CHF NNP cord-023095-4dannjjm 243 37 ( ( -LRB- cord-023095-4dannjjm 243 38 9.4 9.4 CD cord-023095-4dannjjm 243 39 AE AE NNP cord-023095-4dannjjm 243 40 3.06 3.06 CD cord-023095-4dannjjm 243 41 ) ) -RRB- cord-023095-4dannjjm 243 42 groups group NNS cord-023095-4dannjjm 243 43 . . . cord-023095-4dannjjm 244 1 Post post JJ cord-023095-4dannjjm 244 2 - - JJ cord-023095-4dannjjm 244 3 hoc hoc JJ cord-023095-4dannjjm 244 4 comparisons comparison NNS cord-023095-4dannjjm 244 5 demonstrated demonstrate VBD cord-023095-4dannjjm 244 6 a a DT cord-023095-4dannjjm 244 7 difference difference NN cord-023095-4dannjjm 244 8 between between IN cord-023095-4dannjjm 244 9 NC NC NNP cord-023095-4dannjjm 244 10 and and CC cord-023095-4dannjjm 244 11 CHF CHF NNP cord-023095-4dannjjm 244 12 groups group NNS cord-023095-4dannjjm 244 13 ( ( -LRB- cord-023095-4dannjjm 244 14 P p NN cord-023095-4dannjjm 244 15 5 5 CD cord-023095-4dannjjm 244 16 0.038 0.038 CD cord-023095-4dannjjm 244 17 ) ) -RRB- cord-023095-4dannjjm 244 18 . . . cord-023095-4dannjjm 245 1 There there EX cord-023095-4dannjjm 245 2 was be VBD cord-023095-4dannjjm 245 3 no no DT cord-023095-4dannjjm 245 4 difference difference NN cord-023095-4dannjjm 245 5 in in IN cord-023095-4dannjjm 245 6 serum serum NN cord-023095-4dannjjm 245 7 PIIINP PIIINP NNS cord-023095-4dannjjm 245 8 between between IN cord-023095-4dannjjm 245 9 genders gender NNS cord-023095-4dannjjm 245 10 ( ( -LRB- cord-023095-4dannjjm 245 11 P p NN cord-023095-4dannjjm 245 12 5 5 CD cord-023095-4dannjjm 245 13 0.228 0.228 CD cord-023095-4dannjjm 245 14 ) ) -RRB- cord-023095-4dannjjm 245 15 . . . cord-023095-4dannjjm 246 1 In in IN cord-023095-4dannjjm 246 2 the the DT cord-023095-4dannjjm 246 3 univariable univariable JJ cord-023095-4dannjjm 246 4 analysis analysis NN cord-023095-4dannjjm 246 5 CKCS CKCS NNP cord-023095-4dannjjm 246 6 ( ( -LRB- cord-023095-4dannjjm 246 7 yes/ yes/ NNP cord-023095-4dannjjm 246 8 no no NN cord-023095-4dannjjm 246 9 ) ) -RRB- cord-023095-4dannjjm 246 10 ( ( -LRB- cord-023095-4dannjjm 246 11 P p NN cord-023095-4dannjjm 246 12 5 5 CD cord-023095-4dannjjm 246 13 0.016 0.016 CD cord-023095-4dannjjm 246 14 ) ) -RRB- cord-023095-4dannjjm 246 15 was be VBD cord-023095-4dannjjm 246 16 positively positively RB cord-023095-4dannjjm 246 17 associated associate VBN cord-023095-4dannjjm 246 18 with with IN cord-023095-4dannjjm 246 19 serum serum NN cord-023095-4dannjjm 246 20 PIIINP PIIINP NNP cord-023095-4dannjjm 246 21 . . . cord-023095-4dannjjm 247 1 Age age NN cord-023095-4dannjjm 247 2 ( ( -LRB- cord-023095-4dannjjm 247 3 P p NN cord-023095-4dannjjm 247 4 o o NN cord-023095-4dannjjm 247 5 0.0001 0.0001 CD cord-023095-4dannjjm 247 6 ) ) -RRB- cord-023095-4dannjjm 247 7 , , , cord-023095-4dannjjm 247 8 Log Log NNP cord-023095-4dannjjm 247 9 ( ( -LRB- cord-023095-4dannjjm 247 10 LA LA NNP cord-023095-4dannjjm 247 11 / / SYM cord-023095-4dannjjm 247 12 Ao Ao NNP cord-023095-4dannjjm 247 13 ) ) -RRB- cord-023095-4dannjjm 248 1 ( ( -LRB- cord-023095-4dannjjm 248 2 P p NN cord-023095-4dannjjm 248 3 5 5 CD cord-023095-4dannjjm 248 4 0.002 0.002 CD cord-023095-4dannjjm 248 5 ) ) -RRB- cord-023095-4dannjjm 248 6 and and CC cord-023095-4dannjjm 248 7 LVEDDN LVEDDN NNP cord-023095-4dannjjm 248 8 ( ( -LRB- cord-023095-4dannjjm 248 9 P p NN cord-023095-4dannjjm 248 10 5 5 CD cord-023095-4dannjjm 248 11 0.002 0.002 CD cord-023095-4dannjjm 248 12 ) ) -RRB- cord-023095-4dannjjm 248 13 were be VBD cord-023095-4dannjjm 248 14 negatively negatively RB cord-023095-4dannjjm 248 15 associated associate VBN cord-023095-4dannjjm 248 16 with with IN cord-023095-4dannjjm 248 17 serum serum NN cord-023095-4dannjjm 248 18 PIIINP PIIINP NNP cord-023095-4dannjjm 248 19 . . . cord-023095-4dannjjm 249 1 In in IN cord-023095-4dannjjm 249 2 the the DT cord-023095-4dannjjm 249 3 multivariable multivariable JJ cord-023095-4dannjjm 249 4 model model NN cord-023095-4dannjjm 249 5 including include VBG cord-023095-4dannjjm 249 6 all all DT cord-023095-4dannjjm 249 7 dogs dog NNS cord-023095-4dannjjm 249 8 , , , cord-023095-4dannjjm 249 9 LVEDDN LVEDDN NNP cord-023095-4dannjjm 249 10 ( ( -LRB- cord-023095-4dannjjm 249 11 P p NN cord-023095-4dannjjm 249 12 o o NN cord-023095-4dannjjm 249 13 0.0001 0.0001 CD cord-023095-4dannjjm 249 14 , , , cord-023095-4dannjjm 249 15 B b NN cord-023095-4dannjjm 249 16 5 5 CD cord-023095-4dannjjm 249 17 À4.04 à4.04 NN cord-023095-4dannjjm 249 18 ( ( -LRB- cord-023095-4dannjjm 249 19 95%CI 95%ci CD cord-023095-4dannjjm 249 20 5 5 CD cord-023095-4dannjjm 249 21 À6.11 à6.11 DT cord-023095-4dannjjm 249 22 to to IN cord-023095-4dannjjm 249 23 À1.97 À1.97 NNP cord-023095-4dannjjm 249 24 ) ) -RRB- cord-023095-4dannjjm 249 25 ) ) -RRB- cord-023095-4dannjjm 249 26 , , , cord-023095-4dannjjm 249 27 age age NN cord-023095-4dannjjm 249 28 ( ( -LRB- cord-023095-4dannjjm 249 29 P p NN cord-023095-4dannjjm 249 30 5 5 CD cord-023095-4dannjjm 249 31 0.006 0.006 CD cord-023095-4dannjjm 249 32 , , , cord-023095-4dannjjm 249 33 B b NN cord-023095-4dannjjm 249 34 5 5 CD cord-023095-4dannjjm 249 35 À0.28 à0.28 NN cord-023095-4dannjjm 249 36 ( ( -LRB- cord-023095-4dannjjm 249 37 95%CI 95%ci CD cord-023095-4dannjjm 249 38 5 5 CD cord-023095-4dannjjm 249 39 À0.47 à0.47 NN cord-023095-4dannjjm 249 40 to to IN cord-023095-4dannjjm 249 41 À0.08 À0.08 NNP cord-023095-4dannjjm 249 42 ) ) -RRB- cord-023095-4dannjjm 249 43 ) ) -RRB- cord-023095-4dannjjm 249 44 and and CC cord-023095-4dannjjm 249 45 CKCS CKCS NNP cord-023095-4dannjjm 249 46 ( ( -LRB- cord-023095-4dannjjm 249 47 yes/ yes/ NNP cord-023095-4dannjjm 249 48 no no NN cord-023095-4dannjjm 249 49 ) ) -RRB- cord-023095-4dannjjm 250 1 ( ( -LRB- cord-023095-4dannjjm 250 2 P p NN cord-023095-4dannjjm 250 3 5 5 CD cord-023095-4dannjjm 250 4 0.003 0.003 CD cord-023095-4dannjjm 250 5 , , , cord-023095-4dannjjm 250 6 B b NN cord-023095-4dannjjm 250 7 5 5 CD cord-023095-4dannjjm 250 8 2.01 2.01 CD cord-023095-4dannjjm 250 9 ( ( -LRB- cord-023095-4dannjjm 250 10 95%CI 95%ci CD cord-023095-4dannjjm 250 11 5 5 CD cord-023095-4dannjjm 250 12 0.67 0.67 CD cord-023095-4dannjjm 250 13 to to IN cord-023095-4dannjjm 250 14 3.34 3.34 CD cord-023095-4dannjjm 250 15 ) ) -RRB- cord-023095-4dannjjm 250 16 ) ) -RRB- cord-023095-4dannjjm 250 17 were be VBD cord-023095-4dannjjm 250 18 independently independently RB cord-023095-4dannjjm 250 19 associated associate VBN cord-023095-4dannjjm 250 20 with with IN cord-023095-4dannjjm 250 21 serum serum NN cord-023095-4dannjjm 250 22 PIIINP PIIINP NNP cord-023095-4dannjjm 250 23 . . . cord-023095-4dannjjm 251 1 In in IN cord-023095-4dannjjm 251 2 the the DT cord-023095-4dannjjm 251 3 multivariable multivariable JJ cord-023095-4dannjjm 251 4 model model NN cord-023095-4dannjjm 251 5 including include VBG cord-023095-4dannjjm 251 6 only only JJ cord-023095-4dannjjm 251 7 dogs dog NNS cord-023095-4dannjjm 251 8 not not RB cord-023095-4dannjjm 251 9 receiving receive VBG cord-023095-4dannjjm 251 10 therapy therapy NN cord-023095-4dannjjm 251 11 ( ( -LRB- cord-023095-4dannjjm 251 12 n n NN cord-023095-4dannjjm 251 13 5 5 CD cord-023095-4dannjjm 251 14 141 141 CD cord-023095-4dannjjm 251 15 ) ) -RRB- cord-023095-4dannjjm 251 16 , , , cord-023095-4dannjjm 251 17 LVEDDN LVEDDN NNP cord-023095-4dannjjm 251 18 ( ( -LRB- cord-023095-4dannjjm 251 19 P p NN cord-023095-4dannjjm 251 20 5 5 CD cord-023095-4dannjjm 251 21 0.006 0.006 CD cord-023095-4dannjjm 251 22 , , , cord-023095-4dannjjm 251 23 B B NNP cord-023095-4dannjjm 251 24 5 5 CD cord-023095-4dannjjm 251 25 À4.30 À4.30 NNP cord-023095-4dannjjm 251 26 ( ( -LRB- cord-023095-4dannjjm 251 27 95%CI 95%ci CD cord-023095-4dannjjm 251 28 5 5 CD cord-023095-4dannjjm 251 29 À7.32 à7.32 NN cord-023095-4dannjjm 251 30 to to IN cord-023095-4dannjjm 251 31 À1.29 À1.29 NNP cord-023095-4dannjjm 251 32 ) ) -RRB- cord-023095-4dannjjm 251 33 ) ) -RRB- cord-023095-4dannjjm 251 34 , , , cord-023095-4dannjjm 251 35 age age NN cord-023095-4dannjjm 251 36 ( ( -LRB- cord-023095-4dannjjm 251 37 P p NN cord-023095-4dannjjm 251 38 5 5 CD cord-023095-4dannjjm 251 39 0.011 0.011 CD cord-023095-4dannjjm 251 40 , , , cord-023095-4dannjjm 251 41 B b NN cord-023095-4dannjjm 251 42 5 5 CD cord-023095-4dannjjm 251 43 À0.31 À0.31 NNP cord-023095-4dannjjm 251 44 ( ( -LRB- cord-023095-4dannjjm 251 45 95%CI 95%ci CD cord-023095-4dannjjm 251 46 5 5 CD cord-023095-4dannjjm 251 47 À0.55 À0.55 NNS cord-023095-4dannjjm 251 48 to to IN cord-023095-4dannjjm 251 49 À0.07 À0.07 NNS cord-023095-4dannjjm 251 50 ) ) -RRB- cord-023095-4dannjjm 251 51 ) ) -RRB- cord-023095-4dannjjm 251 52 and and CC cord-023095-4dannjjm 251 53 CKCS CKCS NNP cord-023095-4dannjjm 251 54 ( ( -LRB- cord-023095-4dannjjm 251 55 yes/ yes/ NNP cord-023095-4dannjjm 251 56 no no NN cord-023095-4dannjjm 251 57 ) ) -RRB- cord-023095-4dannjjm 251 58 ( ( -LRB- cord-023095-4dannjjm 251 59 P p NN cord-023095-4dannjjm 251 60 5 5 CD cord-023095-4dannjjm 251 61 0.034 0.034 CD cord-023095-4dannjjm 251 62 , , , cord-023095-4dannjjm 251 63 B b NN cord-023095-4dannjjm 251 64 5 5 CD cord-023095-4dannjjm 251 65 1.75 1.75 CD cord-023095-4dannjjm 251 66 ( ( -LRB- cord-023095-4dannjjm 251 67 95%CI 95%ci CD cord-023095-4dannjjm 251 68 5 5 CD cord-023095-4dannjjm 251 69 0.13 0.13 CD cord-023095-4dannjjm 251 70 to to IN cord-023095-4dannjjm 251 71 3.37 3.37 CD cord-023095-4dannjjm 251 72 ) ) -RRB- cord-023095-4dannjjm 251 73 ) ) -RRB- cord-023095-4dannjjm 251 74 were be VBD cord-023095-4dannjjm 251 75 independently independently RB cord-023095-4dannjjm 251 76 associated associate VBN cord-023095-4dannjjm 251 77 with with IN cord-023095-4dannjjm 251 78 serum serum NN cord-023095-4dannjjm 251 79 PIIINP PIIINP NNP cord-023095-4dannjjm 251 80 . . . cord-023095-4dannjjm 252 1 In in IN cord-023095-4dannjjm 252 2 conclusion conclusion NN cord-023095-4dannjjm 252 3 , , , cord-023095-4dannjjm 252 4 serum serum NN cord-023095-4dannjjm 252 5 PIIINP PIIINP NNP cord-023095-4dannjjm 252 6 decreases decrease VBZ cord-023095-4dannjjm 252 7 with with IN cord-023095-4dannjjm 252 8 age age NN cord-023095-4dannjjm 252 9 and and CC cord-023095-4dannjjm 252 10 with with IN cord-023095-4dannjjm 252 11 increasing increase VBG cord-023095-4dannjjm 252 12 LVEDDN LVEDDN NNP cord-023095-4dannjjm 252 13 . . . cord-023095-4dannjjm 253 1 CKCS CKCS NNP cord-023095-4dannjjm 253 2 have have VBP cord-023095-4dannjjm 253 3 higher high JJR cord-023095-4dannjjm 253 4 serum serum NN cord-023095-4dannjjm 253 5 PIIINP PIIINP NNP cord-023095-4dannjjm 253 6 measurements measurement NNS cord-023095-4dannjjm 253 7 independent independent JJ cord-023095-4dannjjm 253 8 of of IN cord-023095-4dannjjm 253 9 age age NN cord-023095-4dannjjm 253 10 and and CC cord-023095-4dannjjm 253 11 LVEDDN LVEDDN NNP cord-023095-4dannjjm 253 12 , , , cord-023095-4dannjjm 253 13 which which WDT cord-023095-4dannjjm 253 14 may may MD cord-023095-4dannjjm 253 15 reflect reflect VB cord-023095-4dannjjm 253 16 a a DT cord-023095-4dannjjm 253 17 difference difference NN cord-023095-4dannjjm 253 18 in in IN cord-023095-4dannjjm 253 19 collagen collagen NN cord-023095-4dannjjm 253 20 turnover turnover NN cord-023095-4dannjjm 253 21 in in IN cord-023095-4dannjjm 253 22 this this DT cord-023095-4dannjjm 253 23 breed breed NN cord-023095-4dannjjm 253 24 . . . cord-023095-4dannjjm 254 1 Left leave VBN cord-023095-4dannjjm 254 2 atrial atrial NN cord-023095-4dannjjm 254 3 ( ( -LRB- cord-023095-4dannjjm 254 4 LA LA NNP cord-023095-4dannjjm 254 5 ) ) -RRB- cord-023095-4dannjjm 254 6 chamber chamber NN cord-023095-4dannjjm 254 7 dilation dilation NN cord-023095-4dannjjm 254 8 and and CC cord-023095-4dannjjm 254 9 congestive congestive JJ cord-023095-4dannjjm 254 10 heart heart NN cord-023095-4dannjjm 254 11 failure failure NN cord-023095-4dannjjm 254 12 ( ( -LRB- cord-023095-4dannjjm 254 13 CHF CHF NNP cord-023095-4dannjjm 254 14 ) ) -RRB- cord-023095-4dannjjm 254 15 are be VBP cord-023095-4dannjjm 254 16 common common JJ cord-023095-4dannjjm 254 17 consequences consequence NNS cord-023095-4dannjjm 254 18 of of IN cord-023095-4dannjjm 254 19 cardiac cardiac JJ cord-023095-4dannjjm 254 20 conditions condition NNS cord-023095-4dannjjm 254 21 in in IN cord-023095-4dannjjm 254 22 cats cat NNS cord-023095-4dannjjm 254 23 . . . cord-023095-4dannjjm 255 1 In in IN cord-023095-4dannjjm 255 2 some some DT cord-023095-4dannjjm 255 3 cases case NNS cord-023095-4dannjjm 255 4 CHF CHF NNP cord-023095-4dannjjm 255 5 is be VBZ cord-023095-4dannjjm 255 6 manifest manifest JJ cord-023095-4dannjjm 255 7 as as IN cord-023095-4dannjjm 255 8 right right JJ cord-023095-4dannjjm 255 9 - - HYPH cord-023095-4dannjjm 255 10 sided sided JJ cord-023095-4dannjjm 255 11 CHF CHF NNP cord-023095-4dannjjm 255 12 ( ( -LRB- cord-023095-4dannjjm 255 13 R R NNP cord-023095-4dannjjm 255 14 - - HYPH cord-023095-4dannjjm 255 15 CHF CHF NNP cord-023095-4dannjjm 255 16 ) ) -RRB- cord-023095-4dannjjm 255 17 or or CC cord-023095-4dannjjm 255 18 pleural pleural JJ cord-023095-4dannjjm 255 19 effusion effusion NN cord-023095-4dannjjm 255 20 , , , cord-023095-4dannjjm 255 21 in in IN cord-023095-4dannjjm 255 22 other other JJ cord-023095-4dannjjm 255 23 cases case NNS cord-023095-4dannjjm 255 24 CHF CHF NNP cord-023095-4dannjjm 255 25 manifests manifest VBZ cord-023095-4dannjjm 255 26 as as IN cord-023095-4dannjjm 255 27 left leave VBN cord-023095-4dannjjm 255 28 - - HYPH cord-023095-4dannjjm 255 29 sided sided JJ cord-023095-4dannjjm 255 30 CHF CHF NNP cord-023095-4dannjjm 255 31 ( ( -LRB- cord-023095-4dannjjm 255 32 L L NNP cord-023095-4dannjjm 255 33 - - HYPH cord-023095-4dannjjm 255 34 CHF CHF NNP cord-023095-4dannjjm 255 35 ) ) -RRB- cord-023095-4dannjjm 255 36 or or CC cord-023095-4dannjjm 255 37 pulmonary pulmonary JJ cord-023095-4dannjjm 255 38 edema edema NN cord-023095-4dannjjm 255 39 . . . cord-023095-4dannjjm 256 1 It -PRON- PRP cord-023095-4dannjjm 256 2 is be VBZ cord-023095-4dannjjm 256 3 not not RB cord-023095-4dannjjm 256 4 always always RB cord-023095-4dannjjm 256 5 readily readily RB cord-023095-4dannjjm 256 6 apparent apparent JJ cord-023095-4dannjjm 256 7 as as IN cord-023095-4dannjjm 256 8 to to IN cord-023095-4dannjjm 256 9 which which WDT cord-023095-4dannjjm 256 10 cats cat NNS cord-023095-4dannjjm 256 11 will will MD cord-023095-4dannjjm 256 12 develop develop VB cord-023095-4dannjjm 256 13 what what WDT cord-023095-4dannjjm 256 14 form form NN cord-023095-4dannjjm 256 15 of of IN cord-023095-4dannjjm 256 16 CHF CHF NNP cord-023095-4dannjjm 256 17 . . . cord-023095-4dannjjm 257 1 A a DT cord-023095-4dannjjm 257 2 general general JJ cord-023095-4dannjjm 257 3 impression impression NN cord-023095-4dannjjm 257 4 has have VBZ cord-023095-4dannjjm 257 5 been be VBN cord-023095-4dannjjm 257 6 that that IN cord-023095-4dannjjm 257 7 LA LA NNP cord-023095-4dannjjm 257 8 enlargement enlargement NN cord-023095-4dannjjm 257 9 is be VBZ cord-023095-4dannjjm 257 10 associated associate VBN cord-023095-4dannjjm 257 11 with with IN cord-023095-4dannjjm 257 12 the the DT cord-023095-4dannjjm 257 13 average average JJ cord-023095-4dannjjm 257 14 burden burden NN cord-023095-4dannjjm 257 15 of of IN cord-023095-4dannjjm 257 16 elevated elevated JJ cord-023095-4dannjjm 257 17 filling filling NN cord-023095-4dannjjm 257 18 pressures pressure NNS cord-023095-4dannjjm 257 19 , , , cord-023095-4dannjjm 257 20 but but CC cord-023095-4dannjjm 257 21 little little JJ cord-023095-4dannjjm 257 22 attention attention NN cord-023095-4dannjjm 257 23 has have VBZ cord-023095-4dannjjm 257 24 been be VBN cord-023095-4dannjjm 257 25 paid pay VBN cord-023095-4dannjjm 257 26 to to IN cord-023095-4dannjjm 257 27 the the DT cord-023095-4dannjjm 257 28 function function NN cord-023095-4dannjjm 257 29 of of IN cord-023095-4dannjjm 257 30 the the DT cord-023095-4dannjjm 257 31 LA LA NNP cord-023095-4dannjjm 257 32 chamber chamber NN cord-023095-4dannjjm 257 33 itself -PRON- PRP cord-023095-4dannjjm 257 34 . . . cord-023095-4dannjjm 258 1 Since since IN cord-023095-4dannjjm 258 2 CHF CHF NNP cord-023095-4dannjjm 258 3 is be VBZ cord-023095-4dannjjm 258 4 classically classically RB cord-023095-4dannjjm 258 5 preceded precede VBN cord-023095-4dannjjm 258 6 by by IN cord-023095-4dannjjm 258 7 abnormal abnormal JJ cord-023095-4dannjjm 258 8 atrial atrial JJ cord-023095-4dannjjm 258 9 chamber chamber NN cord-023095-4dannjjm 258 10 dilation dilation NN cord-023095-4dannjjm 258 11 and and CC cord-023095-4dannjjm 258 12 alterations alteration NNS cord-023095-4dannjjm 258 13 in in IN cord-023095-4dannjjm 258 14 atrial atrial JJ cord-023095-4dannjjm 258 15 chamber chamber NN cord-023095-4dannjjm 258 16 function function NN cord-023095-4dannjjm 258 17 , , , cord-023095-4dannjjm 258 18 we -PRON- PRP cord-023095-4dannjjm 258 19 want want VBP cord-023095-4dannjjm 258 20 to to TO cord-023095-4dannjjm 258 21 understand understand VB cord-023095-4dannjjm 258 22 how how WRB cord-023095-4dannjjm 258 23 these these DT cord-023095-4dannjjm 258 24 changes change NNS cord-023095-4dannjjm 258 25 may may MD cord-023095-4dannjjm 258 26 help help VB cord-023095-4dannjjm 258 27 us -PRON- PRP cord-023095-4dannjjm 258 28 manage manage VB cord-023095-4dannjjm 258 29 or or CC cord-023095-4dannjjm 258 30 predict predict VB cord-023095-4dannjjm 258 31 CHF CHF NNP cord-023095-4dannjjm 258 32 in in IN cord-023095-4dannjjm 258 33 the the DT cord-023095-4dannjjm 258 34 cat cat NN cord-023095-4dannjjm 258 35 . . . cord-023095-4dannjjm 259 1 We -PRON- PRP cord-023095-4dannjjm 259 2 hypothesized hypothesize VBD cord-023095-4dannjjm 259 3 that that IN cord-023095-4dannjjm 259 4 cats cat NNS cord-023095-4dannjjm 259 5 manifesting manifest VBG cord-023095-4dannjjm 259 6 R R NNP cord-023095-4dannjjm 259 7 - - HYPH cord-023095-4dannjjm 259 8 CHF CHF NNP cord-023095-4dannjjm 259 9 have have VB cord-023095-4dannjjm 259 10 LA LA NNP cord-023095-4dannjjm 259 11 failure failure NN cord-023095-4dannjjm 259 12 with with IN cord-023095-4dannjjm 259 13 the the DT cord-023095-4dannjjm 259 14 LA LA NNP cord-023095-4dannjjm 259 15 acting act VBG cord-023095-4dannjjm 259 16 primarily primarily RB cord-023095-4dannjjm 259 17 as as IN cord-023095-4dannjjm 259 18 a a DT cord-023095-4dannjjm 259 19 conduit conduit NN cord-023095-4dannjjm 259 20 , , , cord-023095-4dannjjm 259 21 resulting result VBG cord-023095-4dannjjm 259 22 in in IN cord-023095-4dannjjm 259 23 greater great JJR cord-023095-4dannjjm 259 24 pulmonary pulmonary JJ cord-023095-4dannjjm 259 25 hypertension hypertension NN cord-023095-4dannjjm 259 26 , , , cord-023095-4dannjjm 259 27 whereas whereas IN cord-023095-4dannjjm 259 28 L L NNP cord-023095-4dannjjm 259 29 - - HYPH cord-023095-4dannjjm 259 30 CHF CHF NNP cord-023095-4dannjjm 259 31 cats cat NNS cord-023095-4dannjjm 259 32 maintain maintain VBP cord-023095-4dannjjm 259 33 some some DT cord-023095-4dannjjm 259 34 booster booster NN cord-023095-4dannjjm 259 35 pump pump NN cord-023095-4dannjjm 259 36 and and CC cord-023095-4dannjjm 259 37 reservoir reservoir NN cord-023095-4dannjjm 259 38 function function NN cord-023095-4dannjjm 259 39 . . . cord-023095-4dannjjm 260 1 We -PRON- PRP cord-023095-4dannjjm 260 2 measured measure VBD cord-023095-4dannjjm 260 3 LA LA NNP cord-023095-4dannjjm 260 4 maximum maximum NN cord-023095-4dannjjm 260 5 and and CC cord-023095-4dannjjm 260 6 minimum minimum JJ cord-023095-4dannjjm 260 7 areas area NNS cord-023095-4dannjjm 260 8 from from IN cord-023095-4dannjjm 260 9 right right JJ cord-023095-4dannjjm 260 10 parasternal parasternal JJ cord-023095-4dannjjm 260 11 long long JJ cord-023095-4dannjjm 260 12 axis axis NN cord-023095-4dannjjm 260 13 four four CD cord-023095-4dannjjm 260 14 - - HYPH cord-023095-4dannjjm 260 15 chamber chamber NN cord-023095-4dannjjm 260 16 views view NNS cord-023095-4dannjjm 260 17 on on IN cord-023095-4dannjjm 260 18 2D 2D NNP cord-023095-4dannjjm 260 19 echo echo NN cord-023095-4dannjjm 260 20 , , , cord-023095-4dannjjm 260 21 and and CC cord-023095-4dannjjm 260 22 LA LA NNP cord-023095-4dannjjm 260 23 M M NNP cord-023095-4dannjjm 260 24 - - HYPH cord-023095-4dannjjm 260 25 mode mode NN cord-023095-4dannjjm 260 26 dimensions dimension NNS cord-023095-4dannjjm 260 27 at at IN cord-023095-4dannjjm 260 28 maximum maximum JJ cord-023095-4dannjjm 260 29 , , , cord-023095-4dannjjm 260 30 minimum minimum NN cord-023095-4dannjjm 260 31 , , , cord-023095-4dannjjm 260 32 and and CC cord-023095-4dannjjm 260 33 beginning beginning NN cord-023095-4dannjjm 260 34 of of IN cord-023095-4dannjjm 260 35 atrial atrial JJ cord-023095-4dannjjm 260 36 contraction contraction NN cord-023095-4dannjjm 260 37 . . . cord-023095-4dannjjm 261 1 LA LA NNP cord-023095-4dannjjm 261 2 area area NN cord-023095-4dannjjm 261 3 change change NN cord-023095-4dannjjm 261 4 , , , cord-023095-4dannjjm 261 5 fractional fractional JJ cord-023095-4dannjjm 261 6 shortening shortening NN cord-023095-4dannjjm 261 7 , , , cord-023095-4dannjjm 261 8 active active JJ cord-023095-4dannjjm 261 9 emptying emptying NN cord-023095-4dannjjm 261 10 fraction fraction NN cord-023095-4dannjjm 261 11 , , , cord-023095-4dannjjm 261 12 and and CC cord-023095-4dannjjm 261 13 expansion expansion NN cord-023095-4dannjjm 261 14 index index NN cord-023095-4dannjjm 261 15 were be VBD cord-023095-4dannjjm 261 16 calculated calculate VBN cord-023095-4dannjjm 261 17 from from IN cord-023095-4dannjjm 261 18 these these DT cord-023095-4dannjjm 261 19 measurements measurement NNS cord-023095-4dannjjm 261 20 . . . cord-023095-4dannjjm 262 1 Right right JJ cord-023095-4dannjjm 262 2 ventricular ventricular JJ cord-023095-4dannjjm 262 3 internal internal JJ cord-023095-4dannjjm 262 4 diastolic diastolic JJ cord-023095-4dannjjm 262 5 diameter diameter NN cord-023095-4dannjjm 262 6 was be VBD cord-023095-4dannjjm 262 7 also also RB cord-023095-4dannjjm 262 8 measured measure VBN cord-023095-4dannjjm 262 9 on on IN cord-023095-4dannjjm 262 10 M M NNP cord-023095-4dannjjm 262 11 - - HYPH cord-023095-4dannjjm 262 12 mode mode NN cord-023095-4dannjjm 262 13 views view NNS cord-023095-4dannjjm 262 14 . . . cord-023095-4dannjjm 263 1 Preliminary preliminary JJ cord-023095-4dannjjm 263 2 data datum NNS cord-023095-4dannjjm 263 3 revealed reveal VBD cord-023095-4dannjjm 263 4 that that IN cord-023095-4dannjjm 263 5 maximum maximum JJ cord-023095-4dannjjm 263 6 left left JJ cord-023095-4dannjjm 263 7 atrial atrial JJ cord-023095-4dannjjm 263 8 size size NN cord-023095-4dannjjm 263 9 is be VBZ cord-023095-4dannjjm 263 10 not not RB cord-023095-4dannjjm 263 11 significantly significantly RB cord-023095-4dannjjm 263 12 different different JJ cord-023095-4dannjjm 263 13 between between IN cord-023095-4dannjjm 263 14 R R NNP cord-023095-4dannjjm 263 15 - - HYPH cord-023095-4dannjjm 263 16 CHF CHF NNP cord-023095-4dannjjm 263 17 and and CC cord-023095-4dannjjm 263 18 L L NNP cord-023095-4dannjjm 263 19 - - HYPH cord-023095-4dannjjm 263 20 CHF CHF NNP cord-023095-4dannjjm 263 21 cats cat NNS cord-023095-4dannjjm 263 22 on on IN cord-023095-4dannjjm 263 23 2D 2d CD cord-023095-4dannjjm 263 24 or or CC cord-023095-4dannjjm 263 25 M M NNP cord-023095-4dannjjm 263 26 - - HYPH cord-023095-4dannjjm 263 27 mode mode NN cord-023095-4dannjjm 263 28 measurements measurement NNS cord-023095-4dannjjm 263 29 due due IN cord-023095-4dannjjm 263 30 to to IN cord-023095-4dannjjm 263 31 high high JJ cord-023095-4dannjjm 263 32 variability variability NN cord-023095-4dannjjm 263 33 . . . cord-023095-4dannjjm 264 1 However however RB cord-023095-4dannjjm 264 2 , , , cord-023095-4dannjjm 264 3 total total JJ cord-023095-4dannjjm 264 4 left left JJ cord-023095-4dannjjm 264 5 atrial atrial JJ cord-023095-4dannjjm 264 6 fractional fractional JJ cord-023095-4dannjjm 264 7 shortening shortening NN cord-023095-4dannjjm 264 8 is be VBZ cord-023095-4dannjjm 264 9 significantly significantly RB cord-023095-4dannjjm 264 10 reduced reduce VBN cord-023095-4dannjjm 264 11 in in IN cord-023095-4dannjjm 264 12 R R NNP cord-023095-4dannjjm 264 13 - - HYPH cord-023095-4dannjjm 264 14 CHF CHF NNP cord-023095-4dannjjm 264 15 cats cat NNS cord-023095-4dannjjm 264 16 ( ( -LRB- cord-023095-4dannjjm 264 17 11.32 11.32 CD cord-023095-4dannjjm 264 18 % % NN cord-023095-4dannjjm 264 19 AE AE NNP cord-023095-4dannjjm 264 20 4.9 4.9 CD cord-023095-4dannjjm 264 21 ) ) -RRB- cord-023095-4dannjjm 264 22 compared compare VBN cord-023095-4dannjjm 264 23 to to IN cord-023095-4dannjjm 264 24 L L NNP cord-023095-4dannjjm 264 25 - - HYPH cord-023095-4dannjjm 264 26 CHF CHF NNP cord-023095-4dannjjm 264 27 cats cat NNS cord-023095-4dannjjm 264 28 ( ( -LRB- cord-023095-4dannjjm 264 29 19.7 19.7 CD cord-023095-4dannjjm 264 30 % % NN cord-023095-4dannjjm 264 31 AE AE NNP cord-023095-4dannjjm 264 32 5.1)(p 5.1)(p CD cord-023095-4dannjjm 264 33 5 5 CD cord-023095-4dannjjm 264 34 0.001 0.001 CD cord-023095-4dannjjm 264 35 ) ) -RRB- cord-023095-4dannjjm 264 36 , , , cord-023095-4dannjjm 264 37 and and CC cord-023095-4dannjjm 264 38 R R NNP cord-023095-4dannjjm 264 39 - - HYPH cord-023095-4dannjjm 264 40 CHF CHF NNP cord-023095-4dannjjm 264 41 cats cat NNS cord-023095-4dannjjm 264 42 have have VBP cord-023095-4dannjjm 264 43 reduced reduce VBN cord-023095-4dannjjm 264 44 left leave VBN cord-023095-4dannjjm 264 45 atrial atrial JJ cord-023095-4dannjjm 264 46 active active JJ cord-023095-4dannjjm 264 47 emptying empty VBG cord-023095-4dannjjm 264 48 fraction fraction NN cord-023095-4dannjjm 264 49 ( ( -LRB- cord-023095-4dannjjm 264 50 6.12 6.12 CD cord-023095-4dannjjm 264 51 % % NN cord-023095-4dannjjm 264 52 AE AE NNP cord-023095-4dannjjm 264 53 3.5 3.5 CD cord-023095-4dannjjm 264 54 ) ) -RRB- cord-023095-4dannjjm 264 55 as as IN cord-023095-4dannjjm 264 56 compared compare VBN cord-023095-4dannjjm 264 57 to to IN cord-023095-4dannjjm 264 58 L L NNP cord-023095-4dannjjm 264 59 - - HYPH cord-023095-4dannjjm 264 60 CHF CHF NNP cord-023095-4dannjjm 264 61 cats cat NNS cord-023095-4dannjjm 264 62 ( ( -LRB- cord-023095-4dannjjm 264 63 13.7 13.7 CD cord-023095-4dannjjm 264 64 % % NN cord-023095-4dannjjm 264 65 AE AE NNP cord-023095-4dannjjm 264 66 3)(p 3)(p CD cord-023095-4dannjjm 264 67 o o NN cord-023095-4dannjjm 264 68 0.001 0.001 CD cord-023095-4dannjjm 264 69 ) ) -RRB- cord-023095-4dannjjm 264 70 . . . cord-023095-4dannjjm 265 1 Left leave VBN cord-023095-4dannjjm 265 2 atrial atrial JJ cord-023095-4dannjjm 265 3 expansion expansion NN cord-023095-4dannjjm 265 4 ability ability NN cord-023095-4dannjjm 265 5 is be VBZ cord-023095-4dannjjm 265 6 poorer poor JJR cord-023095-4dannjjm 265 7 in in IN cord-023095-4dannjjm 265 8 R R NNP cord-023095-4dannjjm 265 9 - - HYPH cord-023095-4dannjjm 265 10 CHF CHF NNP cord-023095-4dannjjm 265 11 cats cat NNS cord-023095-4dannjjm 265 12 ( ( -LRB- cord-023095-4dannjjm 265 13 13.11 13.11 CD cord-023095-4dannjjm 265 14 % % NN cord-023095-4dannjjm 265 15 AE AE NNP cord-023095-4dannjjm 265 16 6.7 6.7 CD cord-023095-4dannjjm 265 17 ) ) -RRB- cord-023095-4dannjjm 265 18 than than IN cord-023095-4dannjjm 265 19 in in IN cord-023095-4dannjjm 265 20 L L NNP cord-023095-4dannjjm 265 21 - - HYPH cord-023095-4dannjjm 265 22 CHF CHF NNP cord-023095-4dannjjm 265 23 cats cat NNS cord-023095-4dannjjm 265 24 ( ( -LRB- cord-023095-4dannjjm 265 25 25.0 25.0 CD cord-023095-4dannjjm 265 26 % % NN cord-023095-4dannjjm 265 27 AE AE NNP cord-023095-4dannjjm 265 28 8)(p 8)(p CD cord-023095-4dannjjm 265 29 5 5 CD cord-023095-4dannjjm 265 30 0.002 0.002 CD cord-023095-4dannjjm 265 31 ) ) -RRB- cord-023095-4dannjjm 265 32 . . . cord-023095-4dannjjm 266 1 These these DT cord-023095-4dannjjm 266 2 findings finding NNS cord-023095-4dannjjm 266 3 may may MD cord-023095-4dannjjm 266 4 suggest suggest VB cord-023095-4dannjjm 266 5 that that IN cord-023095-4dannjjm 266 6 atrial atrial JJ cord-023095-4dannjjm 266 7 stiffness stiffness NN cord-023095-4dannjjm 266 8 and and CC cord-023095-4dannjjm 266 9 poorer poor JJR cord-023095-4dannjjm 266 10 atrial atrial JJ cord-023095-4dannjjm 266 11 function function NN cord-023095-4dannjjm 266 12 is be VBZ cord-023095-4dannjjm 266 13 associated associate VBN cord-023095-4dannjjm 266 14 with with IN cord-023095-4dannjjm 266 15 a a DT cord-023095-4dannjjm 266 16 greater great JJR cord-023095-4dannjjm 266 17 degree degree NN cord-023095-4dannjjm 266 18 of of IN cord-023095-4dannjjm 266 19 pulmonary pulmonary JJ cord-023095-4dannjjm 266 20 venous venous NN cord-023095-4dannjjm 266 21 and and CC cord-023095-4dannjjm 266 22 thus thus RB cord-023095-4dannjjm 266 23 secondary secondary JJ cord-023095-4dannjjm 266 24 pulmonary pulmonary JJ cord-023095-4dannjjm 266 25 arterial arterial JJ cord-023095-4dannjjm 266 26 hypertension hypertension NN cord-023095-4dannjjm 266 27 resulting result VBG cord-023095-4dannjjm 266 28 in in IN cord-023095-4dannjjm 266 29 pleural pleural JJ cord-023095-4dannjjm 266 30 effusion effusion NN cord-023095-4dannjjm 266 31 ( ( -LRB- cord-023095-4dannjjm 266 32 R R NNP cord-023095-4dannjjm 266 33 - - HYPH cord-023095-4dannjjm 266 34 CHF CHF NNP cord-023095-4dannjjm 266 35 ) ) -RRB- cord-023095-4dannjjm 266 36 . . . cord-023095-4dannjjm 267 1 Right right JJ cord-023095-4dannjjm 267 2 ventricular ventricular JJ cord-023095-4dannjjm 267 3 diameter diameter NN cord-023095-4dannjjm 267 4 on on IN cord-023095-4dannjjm 267 5 M M NNP cord-023095-4dannjjm 267 6 - - HYPH cord-023095-4dannjjm 267 7 mode mode NN cord-023095-4dannjjm 267 8 was be VBD cord-023095-4dannjjm 267 9 increased increase VBN cord-023095-4dannjjm 267 10 in in IN cord-023095-4dannjjm 267 11 R R NNP cord-023095-4dannjjm 267 12 - - HYPH cord-023095-4dannjjm 267 13 CHF CHF NNP cord-023095-4dannjjm 267 14 cats cat NNS cord-023095-4dannjjm 267 15 ( ( -LRB- cord-023095-4dannjjm 267 16 4.8 4.8 CD cord-023095-4dannjjm 267 17 mm mm NN cord-023095-4dannjjm 267 18 AE AE NNP cord-023095-4dannjjm 267 19 2.1 2.1 CD cord-023095-4dannjjm 267 20 ) ) -RRB- cord-023095-4dannjjm 267 21 when when WRB cord-023095-4dannjjm 267 22 compared compare VBN cord-023095-4dannjjm 267 23 to to IN cord-023095-4dannjjm 267 24 L L NNP cord-023095-4dannjjm 267 25 - - HYPH cord-023095-4dannjjm 267 26 CHF CHF NNP cord-023095-4dannjjm 267 27 cats cat NNS cord-023095-4dannjjm 267 28 ( ( -LRB- cord-023095-4dannjjm 267 29 2.89 2.89 CD cord-023095-4dannjjm 267 30 mm mm NN cord-023095-4dannjjm 267 31 AE AE NNP cord-023095-4dannjjm 267 32 0.8)(p 0.8)(p CD cord-023095-4dannjjm 267 33 5 5 CD cord-023095-4dannjjm 267 34 0.002 0.002 CD cord-023095-4dannjjm 267 35 ) ) -RRB- cord-023095-4dannjjm 267 36 and and CC cord-023095-4dannjjm 267 37 normal normal JJ cord-023095-4dannjjm 267 38 cats cat NNS cord-023095-4dannjjm 267 39 ( ( -LRB- cord-023095-4dannjjm 267 40 2.74 2.74 CD cord-023095-4dannjjm 267 41 mm mm NNS cord-023095-4dannjjm 267 42 AE AE NNP cord-023095-4dannjjm 267 43 0.8)(p 0.8)(p CD cord-023095-4dannjjm 267 44 5 5 CD cord-023095-4dannjjm 267 45 0.002 0.002 CD cord-023095-4dannjjm 267 46 ) ) -RRB- cord-023095-4dannjjm 267 47 , , , cord-023095-4dannjjm 267 48 which which WDT cord-023095-4dannjjm 267 49 may may MD cord-023095-4dannjjm 267 50 also also RB cord-023095-4dannjjm 267 51 be be VB cord-023095-4dannjjm 267 52 evidence evidence NN cord-023095-4dannjjm 267 53 for for IN cord-023095-4dannjjm 267 54 a a DT cord-023095-4dannjjm 267 55 greater great JJR cord-023095-4dannjjm 267 56 degree degree NN cord-023095-4dannjjm 267 57 of of IN cord-023095-4dannjjm 267 58 pulmonary pulmonary JJ cord-023095-4dannjjm 267 59 arterial arterial JJ cord-023095-4dannjjm 267 60 hypertension hypertension NN cord-023095-4dannjjm 267 61 in in IN cord-023095-4dannjjm 267 62 these these DT cord-023095-4dannjjm 267 63 cats cat NNS cord-023095-4dannjjm 267 64 . . . cord-023095-4dannjjm 268 1 Episodic episodic JJ cord-023095-4dannjjm 268 2 weakness weakness NN cord-023095-4dannjjm 268 3 and and CC cord-023095-4dannjjm 268 4 syncope syncope NN cord-023095-4dannjjm 268 5 are be VBP cord-023095-4dannjjm 268 6 common common JJ cord-023095-4dannjjm 268 7 in in IN cord-023095-4dannjjm 268 8 Boxer Boxer NNP cord-023095-4dannjjm 268 9 dogs dog NNS cord-023095-4dannjjm 268 10 . . . cord-023095-4dannjjm 269 1 Reported report VBN cord-023095-4dannjjm 269 2 causes cause NNS cord-023095-4dannjjm 269 3 include include VBP cord-023095-4dannjjm 269 4 rapid rapid JJ cord-023095-4dannjjm 269 5 ventricular ventricular JJ cord-023095-4dannjjm 269 6 tachycardia tachycardia NN cord-023095-4dannjjm 269 7 ( ( -LRB- cord-023095-4dannjjm 269 8 VT VT NNP cord-023095-4dannjjm 269 9 ) ) -RRB- cord-023095-4dannjjm 269 10 and and CC cord-023095-4dannjjm 269 11 exertion exertion NN cord-023095-4dannjjm 269 12 - - HYPH cord-023095-4dannjjm 269 13 excitement excitement NN cord-023095-4dannjjm 269 14 triggered trigger VBD cord-023095-4dannjjm 269 15 neurally neurally RB cord-023095-4dannjjm 269 16 - - HYPH cord-023095-4dannjjm 269 17 mediated mediate VBN cord-023095-4dannjjm 269 18 bradycardia bradycardia NN cord-023095-4dannjjm 269 19 ( ( -LRB- cord-023095-4dannjjm 269 20 NMB NMB NNP cord-023095-4dannjjm 269 21 ) ) -RRB- cord-023095-4dannjjm 270 1 .The .The . cord-023095-4dannjjm 271 1 purpose purpose NN cord-023095-4dannjjm 271 2 of of IN cord-023095-4dannjjm 271 3 this this DT cord-023095-4dannjjm 271 4 retrospective retrospective JJ cord-023095-4dannjjm 271 5 study study NN cord-023095-4dannjjm 271 6 is be VBZ cord-023095-4dannjjm 271 7 to to TO cord-023095-4dannjjm 271 8 describe describe VB cord-023095-4dannjjm 271 9 the the DT cord-023095-4dannjjm 271 10 features feature NNS cord-023095-4dannjjm 271 11 of of IN cord-023095-4dannjjm 271 12 presumed presume VBN cord-023095-4dannjjm 271 13 NMB NMB NNP cord-023095-4dannjjm 271 14 in in IN cord-023095-4dannjjm 271 15 Boxers Boxers NNPS cord-023095-4dannjjm 271 16 . . . cord-023095-4dannjjm 272 1 To to TO cord-023095-4dannjjm 272 2 be be VB cord-023095-4dannjjm 272 3 included include VBN cord-023095-4dannjjm 272 4 in in IN cord-023095-4dannjjm 272 5 the the DT cord-023095-4dannjjm 272 6 study study NN cord-023095-4dannjjm 272 7 , , , cord-023095-4dannjjm 272 8 each each DT cord-023095-4dannjjm 272 9 dog dog NN cord-023095-4dannjjm 272 10 must must MD cord-023095-4dannjjm 272 11 have have VB cord-023095-4dannjjm 272 12 been be VBN cord-023095-4dannjjm 272 13 overtly overtly RB cord-023095-4dannjjm 272 14 healthy healthy JJ cord-023095-4dannjjm 272 15 with with IN cord-023095-4dannjjm 272 16 a a DT cord-023095-4dannjjm 272 17 history history NN cord-023095-4dannjjm 272 18 of of IN cord-023095-4dannjjm 272 19 exertion exertion NN cord-023095-4dannjjm 272 20 - - HYPH cord-023095-4dannjjm 272 21 excitement excitement NN cord-023095-4dannjjm 272 22 triggered trigger VBD cord-023095-4dannjjm 272 23 syncope syncope NN cord-023095-4dannjjm 272 24 or or CC cord-023095-4dannjjm 272 25 presyncope presyncope NN cord-023095-4dannjjm 272 26 ; ; , cord-023095-4dannjjm 272 27 had have VBD cord-023095-4dannjjm 272 28 a a DT cord-023095-4dannjjm 272 29 normal normal JJ cord-023095-4dannjjm 272 30 echocardiogram echocardiogram NN cord-023095-4dannjjm 272 31 ( ( -LRB- cord-023095-4dannjjm 272 32 EC EC NNP cord-023095-4dannjjm 272 33 ) ) -RRB- cord-023095-4dannjjm 272 34 ; ; , cord-023095-4dannjjm 272 35 had have VBD cord-023095-4dannjjm 272 36 absence absence NN cord-023095-4dannjjm 272 37 of of IN cord-023095-4dannjjm 272 38 VT VT NNP cord-023095-4dannjjm 272 39 and and CC cord-023095-4dannjjm 272 40 fewer few JJR cord-023095-4dannjjm 272 41 than than IN cord-023095-4dannjjm 272 42 500 500 CD cord-023095-4dannjjm 272 43 ventricular ventricular JJ cord-023095-4dannjjm 272 44 premature premature JJ cord-023095-4dannjjm 272 45 complexes complex NNS cord-023095-4dannjjm 272 46 ( ( -LRB- cord-023095-4dannjjm 272 47 VPC VPC NNP cord-023095-4dannjjm 272 48 ) ) -RRB- cord-023095-4dannjjm 272 49 on on IN cord-023095-4dannjjm 272 50 an an DT cord-023095-4dannjjm 272 51 initial initial JJ cord-023095-4dannjjm 272 52 and and CC cord-023095-4dannjjm 272 53 subsequent subsequent JJ cord-023095-4dannjjm 272 54 24 24 CD cord-023095-4dannjjm 272 55 hour hour NN cord-023095-4dannjjm 272 56 Holter Holter NNP cord-023095-4dannjjm 272 57 recordings recording NNS cord-023095-4dannjjm 272 58 ; ; : cord-023095-4dannjjm 272 59 and and CC cord-023095-4dannjjm 272 60 been be VBN cord-023095-4dannjjm 272 61 alive alive JJ cord-023095-4dannjjm 272 62 and and CC cord-023095-4dannjjm 272 63 overtly overtly RB cord-023095-4dannjjm 272 64 healthy healthy JJ cord-023095-4dannjjm 272 65 for for IN cord-023095-4dannjjm 272 66 at at RB cord-023095-4dannjjm 272 67 least least JJS cord-023095-4dannjjm 272 68 six six CD cord-023095-4dannjjm 272 69 months month NNS cord-023095-4dannjjm 272 70 following follow VBG cord-023095-4dannjjm 272 71 the the DT cord-023095-4dannjjm 272 72 initial initial JJ cord-023095-4dannjjm 272 73 evaluation evaluation NN cord-023095-4dannjjm 272 74 . . . cord-023095-4dannjjm 273 1 A a DT cord-023095-4dannjjm 273 2 total total NN cord-023095-4dannjjm 273 3 of of IN cord-023095-4dannjjm 273 4 27 27 CD cord-023095-4dannjjm 273 5 Boxers Boxers NNPS cord-023095-4dannjjm 273 6 were be VBD cord-023095-4dannjjm 273 7 identified identify VBN cord-023095-4dannjjm 273 8 . . . cord-023095-4dannjjm 274 1 Sixteen sixteen CD cord-023095-4dannjjm 274 2 were be VBD cord-023095-4dannjjm 274 3 male male JJ cord-023095-4dannjjm 274 4 and and CC cord-023095-4dannjjm 274 5 11 11 CD cord-023095-4dannjjm 274 6 were be VBD cord-023095-4dannjjm 274 7 female female JJ cord-023095-4dannjjm 274 8 . . . cord-023095-4dannjjm 275 1 Most Most JJS cord-023095-4dannjjm 275 2 ( ( -LRB- cord-023095-4dannjjm 275 3 90 90 CD cord-023095-4dannjjm 275 4 % % NN cord-023095-4dannjjm 275 5 ) ) -RRB- cord-023095-4dannjjm 276 1 dogs dog NNS cord-023095-4dannjjm 276 2 were be VBD cord-023095-4dannjjm 276 3 either either CC cord-023095-4dannjjm 276 4 less less JJR cord-023095-4dannjjm 276 5 than than IN cord-023095-4dannjjm 276 6 4 4 CD cord-023095-4dannjjm 276 7 or or CC cord-023095-4dannjjm 276 8 more more JJR cord-023095-4dannjjm 276 9 than than IN cord-023095-4dannjjm 276 10 7 7 CD cord-023095-4dannjjm 276 11 years year NNS cord-023095-4dannjjm 276 12 of of IN cord-023095-4dannjjm 276 13 age age NN cord-023095-4dannjjm 276 14 . . . cord-023095-4dannjjm 277 1 Most Most JJS cord-023095-4dannjjm 277 2 dogs dog NNS cord-023095-4dannjjm 277 3 had have VBD cord-023095-4dannjjm 277 4 multiple multiple JJ cord-023095-4dannjjm 277 5 , , , cord-023095-4dannjjm 277 6 but but CC cord-023095-4dannjjm 277 7 infrequent infrequent JJ cord-023095-4dannjjm 277 8 , , , cord-023095-4dannjjm 277 9 episodes episode NNS cord-023095-4dannjjm 277 10 and and CC cord-023095-4dannjjm 277 11 heart heart NN cord-023095-4dannjjm 277 12 rhythm rhythm NN cord-023095-4dannjjm 277 13 was be VBD cord-023095-4dannjjm 277 14 documented document VBN cord-023095-4dannjjm 277 15 at at IN cord-023095-4dannjjm 277 16 the the DT cord-023095-4dannjjm 277 17 time time NN cord-023095-4dannjjm 277 18 of of IN cord-023095-4dannjjm 277 19 an an DT cord-023095-4dannjjm 277 20 episode episode NN cord-023095-4dannjjm 277 21 in in IN cord-023095-4dannjjm 277 22 only only RB cord-023095-4dannjjm 277 23 8 8 CD cord-023095-4dannjjm 277 24 ( ( -LRB- cord-023095-4dannjjm 277 25 30 30 CD cord-023095-4dannjjm 277 26 % % NN cord-023095-4dannjjm 277 27 ) ) -RRB- cord-023095-4dannjjm 277 28 and and CC cord-023095-4dannjjm 277 29 only only RB cord-023095-4dannjjm 277 30 once once RB cord-023095-4dannjjm 277 31 ( ( -LRB- cord-023095-4dannjjm 277 32 bradycardia bradycardia JJ cord-023095-4dannjjm 277 33 ) ) -RRB- cord-023095-4dannjjm 277 34 on on IN cord-023095-4dannjjm 277 35 the the DT cord-023095-4dannjjm 277 36 first first JJ cord-023095-4dannjjm 277 37 Holter Holter NNP cord-023095-4dannjjm 277 38 recording recording NN cord-023095-4dannjjm 277 39 . . . cord-023095-4dannjjm 278 1 Owners owner NNS cord-023095-4dannjjm 278 2 were be VBD cord-023095-4dannjjm 278 3 instructed instruct VBN cord-023095-4dannjjm 278 4 to to TO cord-023095-4dannjjm 278 5 attempt attempt VB cord-023095-4dannjjm 278 6 to to TO cord-023095-4dannjjm 278 7 precipitate precipitate VB cord-023095-4dannjjm 278 8 episodes episode NNS cord-023095-4dannjjm 278 9 . . . cord-023095-4dannjjm 279 1 Bradycardia bradycardia JJ cord-023095-4dannjjm 279 2 related related JJ cord-023095-4dannjjm 279 3 episodes episode NNS cord-023095-4dannjjm 279 4 were be VBD cord-023095-4dannjjm 279 5 subsequently subsequently RB cord-023095-4dannjjm 279 6 recorded record VBN cord-023095-4dannjjm 279 7 in in IN cord-023095-4dannjjm 279 8 5 5 CD cord-023095-4dannjjm 279 9 : : : cord-023095-4dannjjm 279 10 during during IN cord-023095-4dannjjm 279 11 the the DT cord-023095-4dannjjm 279 12 2nd 2nd JJ cord-023095-4dannjjm 279 13 ( ( -LRB- cord-023095-4dannjjm 279 14 1 1 CD cord-023095-4dannjjm 279 15 ) ) -RRB- cord-023095-4dannjjm 279 16 , , , cord-023095-4dannjjm 279 17 3rd 3rd NN cord-023095-4dannjjm 279 18 ( ( -LRB- cord-023095-4dannjjm 279 19 2 2 CD cord-023095-4dannjjm 279 20 ) ) -RRB- cord-023095-4dannjjm 279 21 or or CC cord-023095-4dannjjm 279 22 4th 4th JJ cord-023095-4dannjjm 279 23 ( ( -LRB- cord-023095-4dannjjm 279 24 1 1 CD cord-023095-4dannjjm 279 25 ) ) -RRB- cord-023095-4dannjjm 279 26 day day NN cord-023095-4dannjjm 279 27 of of IN cord-023095-4dannjjm 279 28 120 120 CD cord-023095-4dannjjm 279 29 hour hour NN cord-023095-4dannjjm 279 30 Holter Holter NNP cord-023095-4dannjjm 279 31 recordings recording NNS cord-023095-4dannjjm 279 32 and and CC cord-023095-4dannjjm 279 33 during during IN cord-023095-4dannjjm 279 34 the the DT cord-023095-4dannjjm 279 35 5th 5th JJ cord-023095-4dannjjm 279 36 day day NN cord-023095-4dannjjm 279 37 of of IN cord-023095-4dannjjm 279 38 an an DT cord-023095-4dannjjm 279 39 event event NN cord-023095-4dannjjm 279 40 recording record VBG cord-023095-4dannjjm 279 41 ( ( -LRB- cord-023095-4dannjjm 279 42 1 1 CD cord-023095-4dannjjm 279 43 ) ) -RRB- cord-023095-4dannjjm 279 44 . . . cord-023095-4dannjjm 280 1 Collapse collapse VB cord-023095-4dannjjm 280 2 and and CC cord-023095-4dannjjm 280 3 bradycardia bradycardia NN cord-023095-4dannjjm 280 4 were be VBD cord-023095-4dannjjm 280 5 documented document VBN cord-023095-4dannjjm 280 6 during during IN cord-023095-4dannjjm 280 7 auscultation auscultation NN cord-023095-4dannjjm 280 8 in in IN cord-023095-4dannjjm 280 9 2 2 CD cord-023095-4dannjjm 280 10 additional additional JJ cord-023095-4dannjjm 280 11 dogs dog NNS cord-023095-4dannjjm 280 12 . . . cord-023095-4dannjjm 281 1 The the DT cord-023095-4dannjjm 281 2 heart heart NN cord-023095-4dannjjm 281 3 rate rate NN cord-023095-4dannjjm 281 4 during during IN cord-023095-4dannjjm 281 5 syncope syncope NN cord-023095-4dannjjm 281 6 was be VBD cord-023095-4dannjjm 281 7 never never RB cord-023095-4dannjjm 281 8 documented document VBN cord-023095-4dannjjm 281 9 in in IN cord-023095-4dannjjm 281 10 19 19 CD cord-023095-4dannjjm 281 11 ( ( -LRB- cord-023095-4dannjjm 281 12 70 70 CD cord-023095-4dannjjm 281 13 % % NN cord-023095-4dannjjm 281 14 ) ) -RRB- cord-023095-4dannjjm 281 15 dogs dog NNS cord-023095-4dannjjm 281 16 . . . cord-023095-4dannjjm 282 1 A a DT cord-023095-4dannjjm 282 2 presumptive presumptive JJ cord-023095-4dannjjm 282 3 diagnosis diagnosis NN cord-023095-4dannjjm 282 4 of of IN cord-023095-4dannjjm 282 5 NMB NMB NNP cord-023095-4dannjjm 282 6 was be VBD cord-023095-4dannjjm 282 7 based base VBN cord-023095-4dannjjm 282 8 on on IN cord-023095-4dannjjm 282 9 the the DT cord-023095-4dannjjm 282 10 absence absence NN cord-023095-4dannjjm 282 11 of of IN cord-023095-4dannjjm 282 12 initial initial JJ cord-023095-4dannjjm 282 13 and and CC cord-023095-4dannjjm 282 14 follow follow NN cord-023095-4dannjjm 282 15 - - HYPH cord-023095-4dannjjm 282 16 up up NN cord-023095-4dannjjm 282 17 of of IN cord-023095-4dannjjm 282 18 EC EC NNP cord-023095-4dannjjm 282 19 abnormalities abnormality NNS cord-023095-4dannjjm 282 20 and and CC cord-023095-4dannjjm 282 21 the the DT cord-023095-4dannjjm 282 22 presence presence NN cord-023095-4dannjjm 282 23 of of IN cord-023095-4dannjjm 282 24 no no DT cord-023095-4dannjjm 282 25 or or CC cord-023095-4dannjjm 282 26 few few JJ cord-023095-4dannjjm 282 27 VPC VPC NNP cord-023095-4dannjjm 282 28 during during IN cord-023095-4dannjjm 282 29 extended extended JJ cord-023095-4dannjjm 282 30 ECG ECG NNP cord-023095-4dannjjm 282 31 monitoring monitoring NN cord-023095-4dannjjm 282 32 . . . cord-023095-4dannjjm 283 1 Multiple multiple JJ cord-023095-4dannjjm 283 2 Holter Holter NNP cord-023095-4dannjjm 283 3 recordings recording NNS cord-023095-4dannjjm 283 4 ( ( -LRB- cord-023095-4dannjjm 283 5 48 48 CD cord-023095-4dannjjm 283 6 - - SYM cord-023095-4dannjjm 283 7 168 168 CD cord-023095-4dannjjm 283 8 hours hour NNS cord-023095-4dannjjm 283 9 ) ) -RRB- cord-023095-4dannjjm 283 10 were be VBD cord-023095-4dannjjm 283 11 performed perform VBN cord-023095-4dannjjm 283 12 in in IN cord-023095-4dannjjm 283 13 8 8 CD cord-023095-4dannjjm 283 14 of of IN cord-023095-4dannjjm 283 15 19 19 CD cord-023095-4dannjjm 283 16 ( ( -LRB- cord-023095-4dannjjm 283 17 42 42 CD cord-023095-4dannjjm 283 18 % % NN cord-023095-4dannjjm 283 19 ) ) -RRB- cord-023095-4dannjjm 284 1 dogs dog NNS cord-023095-4dannjjm 284 2 and and CC cord-023095-4dannjjm 284 3 event event NN cord-023095-4dannjjm 284 4 monitoring monitoring NN cord-023095-4dannjjm 284 5 of of IN cord-023095-4dannjjm 284 6 5 5 CD cord-023095-4dannjjm 284 7 days day NNS cord-023095-4dannjjm 284 8 ( ( -LRB- cord-023095-4dannjjm 284 9 1 1 CD cord-023095-4dannjjm 284 10 ) ) -RRB- cord-023095-4dannjjm 284 11 and and CC cord-023095-4dannjjm 284 12 7 7 CD cord-023095-4dannjjm 284 13 days day NNS cord-023095-4dannjjm 284 14 ( ( -LRB- cord-023095-4dannjjm 284 15 1 1 CD cord-023095-4dannjjm 284 16 ) ) -RRB- cord-023095-4dannjjm 284 17 was be VBD cord-023095-4dannjjm 284 18 performed perform VBN cord-023095-4dannjjm 284 19 in in IN cord-023095-4dannjjm 284 20 2 2 CD cord-023095-4dannjjm 284 21 additional additional JJ cord-023095-4dannjjm 284 22 dogs dog NNS cord-023095-4dannjjm 284 23 . . . cord-023095-4dannjjm 285 1 In in IN cord-023095-4dannjjm 285 2 conclusion conclusion NN cord-023095-4dannjjm 285 3 , , , cord-023095-4dannjjm 285 4 documentation documentation NN cord-023095-4dannjjm 285 5 of of IN cord-023095-4dannjjm 285 6 the the DT cord-023095-4dannjjm 285 7 heart heart NN cord-023095-4dannjjm 285 8 rhythm rhythm NN cord-023095-4dannjjm 285 9 during during IN cord-023095-4dannjjm 285 10 episodes episode NNS cord-023095-4dannjjm 285 11 of of IN cord-023095-4dannjjm 285 12 collapse collapse NN cord-023095-4dannjjm 285 13 was be VBD cord-023095-4dannjjm 285 14 difficult difficult JJ cord-023095-4dannjjm 285 15 , , , cord-023095-4dannjjm 285 16 accomplished accomplish VBN cord-023095-4dannjjm 285 17 in in IN cord-023095-4dannjjm 285 18 only only RB cord-023095-4dannjjm 285 19 30 30 CD cord-023095-4dannjjm 285 20 % % NN cord-023095-4dannjjm 285 21 and and CC cord-023095-4dannjjm 285 22 was be VBD cord-023095-4dannjjm 285 23 unlikely unlikely JJ cord-023095-4dannjjm 285 24 during during IN cord-023095-4dannjjm 285 25 the the DT cord-023095-4dannjjm 285 26 first first JJ cord-023095-4dannjjm 285 27 Holter Holter NNP cord-023095-4dannjjm 285 28 recording recording NN cord-023095-4dannjjm 285 29 . . . cord-023095-4dannjjm 286 1 In in IN cord-023095-4dannjjm 286 2 Boxers boxer NNS cord-023095-4dannjjm 286 3 with with IN cord-023095-4dannjjm 286 4 suspected suspect VBN cord-023095-4dannjjm 286 5 NMB NMB NNP cord-023095-4dannjjm 286 6 , , , cord-023095-4dannjjm 286 7 extended extended JJ cord-023095-4dannjjm 286 8 ECG ECG NNP cord-023095-4dannjjm 286 9 monitoring monitoring NN cord-023095-4dannjjm 286 10 and and CC cord-023095-4dannjjm 286 11 implantable implantable JJ cord-023095-4dannjjm 286 12 loop loop NN cord-023095-4dannjjm 286 13 recorders recorder NNS cord-023095-4dannjjm 286 14 may may MD cord-023095-4dannjjm 286 15 be be VB cord-023095-4dannjjm 286 16 best good JJS cord-023095-4dannjjm 286 17 for for IN cord-023095-4dannjjm 286 18 HR hr NN cord-023095-4dannjjm 286 19 documentation documentation NN cord-023095-4dannjjm 286 20 . . . cord-023095-4dannjjm 287 1 Arrhythmogenic Arrhythmogenic NNP cord-023095-4dannjjm 287 2 right right JJ cord-023095-4dannjjm 287 3 ventricular ventricular JJ cord-023095-4dannjjm 287 4 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 287 5 ( ( -LRB- cord-023095-4dannjjm 287 6 ARVC ARVC NNP cord-023095-4dannjjm 287 7 ) ) -RRB- cord-023095-4dannjjm 287 8 is be VBZ cord-023095-4dannjjm 287 9 an an DT cord-023095-4dannjjm 287 10 inherited inherit VBN cord-023095-4dannjjm 287 11 myocardial myocardial JJ cord-023095-4dannjjm 287 12 disease disease NN cord-023095-4dannjjm 287 13 with with IN cord-023095-4dannjjm 287 14 high high JJ cord-023095-4dannjjm 287 15 prevalence prevalence NN cord-023095-4dannjjm 287 16 in in IN cord-023095-4dannjjm 287 17 the the DT cord-023095-4dannjjm 287 18 boxer boxer NN cord-023095-4dannjjm 287 19 dog dog NN cord-023095-4dannjjm 287 20 population population NN cord-023095-4dannjjm 287 21 , , , cord-023095-4dannjjm 287 22 and and CC cord-023095-4dannjjm 287 23 is be VBZ cord-023095-4dannjjm 287 24 associated associate VBN cord-023095-4dannjjm 287 25 with with IN cord-023095-4dannjjm 287 26 sustained sustained JJ cord-023095-4dannjjm 287 27 monomorphic monomorphic JJ cord-023095-4dannjjm 287 28 ventricular ventricular JJ cord-023095-4dannjjm 287 29 tachycardia tachycardia NN cord-023095-4dannjjm 287 30 , , , cord-023095-4dannjjm 287 31 sudden sudden JJ cord-023095-4dannjjm 287 32 cardiac cardiac JJ cord-023095-4dannjjm 287 33 death death NN cord-023095-4dannjjm 287 34 , , , cord-023095-4dannjjm 287 35 and and CC cord-023095-4dannjjm 287 36 replacement replacement NN cord-023095-4dannjjm 287 37 of of IN cord-023095-4dannjjm 287 38 myocardium myocardium NN cord-023095-4dannjjm 287 39 with with IN cord-023095-4dannjjm 287 40 fatty fatty JJ cord-023095-4dannjjm 287 41 or or CC cord-023095-4dannjjm 287 42 fibro fibro NN cord-023095-4dannjjm 287 43 - - HYPH cord-023095-4dannjjm 287 44 fatty fatty JJ cord-023095-4dannjjm 287 45 tissue tissue NN cord-023095-4dannjjm 287 46 . . . cord-023095-4dannjjm 288 1 Though though IN cord-023095-4dannjjm 288 2 several several JJ cord-023095-4dannjjm 288 3 genes gene NNS cord-023095-4dannjjm 288 4 have have VBP cord-023095-4dannjjm 288 5 been be VBN cord-023095-4dannjjm 288 6 linked link VBN cord-023095-4dannjjm 288 7 to to IN cord-023095-4dannjjm 288 8 the the DT cord-023095-4dannjjm 288 9 disease disease NN cord-023095-4dannjjm 288 10 both both CC cord-023095-4dannjjm 288 11 in in IN cord-023095-4dannjjm 288 12 humans human NNS cord-023095-4dannjjm 288 13 and and CC cord-023095-4dannjjm 288 14 in in IN cord-023095-4dannjjm 288 15 boxers boxer NNS cord-023095-4dannjjm 288 16 , , , cord-023095-4dannjjm 288 17 the the DT cord-023095-4dannjjm 288 18 etiology etiology NN cord-023095-4dannjjm 288 19 of of IN cord-023095-4dannjjm 288 20 ARVC ARVC NNP cord-023095-4dannjjm 288 21 is be VBZ cord-023095-4dannjjm 288 22 still still RB cord-023095-4dannjjm 288 23 unclear unclear JJ cord-023095-4dannjjm 288 24 . . . cord-023095-4dannjjm 289 1 Several several JJ cord-023095-4dannjjm 289 2 mechanisms mechanism NNS cord-023095-4dannjjm 289 3 for for IN cord-023095-4dannjjm 289 4 the the DT cord-023095-4dannjjm 289 5 development development NN cord-023095-4dannjjm 289 6 of of IN cord-023095-4dannjjm 289 7 ARVC ARVC NNP cord-023095-4dannjjm 289 8 have have VBP cord-023095-4dannjjm 289 9 been be VBN cord-023095-4dannjjm 289 10 suggested suggest VBN cord-023095-4dannjjm 289 11 , , , cord-023095-4dannjjm 289 12 including include VBG cord-023095-4dannjjm 289 13 dysfunction dysfunction NN cord-023095-4dannjjm 289 14 of of IN cord-023095-4dannjjm 289 15 the the DT cord-023095-4dannjjm 289 16 canonical canonical JJ cord-023095-4dannjjm 289 17 Wnt Wnt NNP cord-023095-4dannjjm 289 18 pathway pathway NN cord-023095-4dannjjm 289 19 , , , cord-023095-4dannjjm 289 20 which which WDT cord-023095-4dannjjm 289 21 results result VBZ cord-023095-4dannjjm 289 22 in in IN cord-023095-4dannjjm 289 23 an an DT cord-023095-4dannjjm 289 24 ARVC ARVC NNP cord-023095-4dannjjm 289 25 phenotype phenotype NN cord-023095-4dannjjm 289 26 in in IN cord-023095-4dannjjm 289 27 the the DT cord-023095-4dannjjm 289 28 mouse mouse NN cord-023095-4dannjjm 289 29 . . . cord-023095-4dannjjm 290 1 The the DT cord-023095-4dannjjm 290 2 canonical canonical JJ cord-023095-4dannjjm 290 3 Wnt Wnt NNP cord-023095-4dannjjm 290 4 pathway pathway NN cord-023095-4dannjjm 290 5 has have VBZ cord-023095-4dannjjm 290 6 been be VBN cord-023095-4dannjjm 290 7 linked link VBN cord-023095-4dannjjm 290 8 to to IN cord-023095-4dannjjm 290 9 many many JJ cord-023095-4dannjjm 290 10 cellular cellular JJ cord-023095-4dannjjm 290 11 functions function NNS cord-023095-4dannjjm 290 12 , , , cord-023095-4dannjjm 290 13 including include VBG cord-023095-4dannjjm 290 14 growth growth NN cord-023095-4dannjjm 290 15 and and CC cord-023095-4dannjjm 290 16 differentiation differentiation NN cord-023095-4dannjjm 290 17 of of IN cord-023095-4dannjjm 290 18 adipocytes adipocyte NNS cord-023095-4dannjjm 290 19 . . . cord-023095-4dannjjm 291 1 With with IN cord-023095-4dannjjm 291 2 the the DT cord-023095-4dannjjm 291 3 recent recent JJ cord-023095-4dannjjm 291 4 discovery discovery NN cord-023095-4dannjjm 291 5 that that IN cord-023095-4dannjjm 291 6 the the DT cord-023095-4dannjjm 291 7 gene gene NN cord-023095-4dannjjm 291 8 encoding encoding NN cord-023095-4dannjjm 291 9 striatin striatin NNP cord-023095-4dannjjm 291 10 , , , cord-023095-4dannjjm 291 11 a a DT cord-023095-4dannjjm 291 12 protein protein NN cord-023095-4dannjjm 291 13 involved involve VBN cord-023095-4dannjjm 291 14 in in IN cord-023095-4dannjjm 291 15 Wnt Wnt NNP cord-023095-4dannjjm 291 16 signaling signal VBG cord-023095-4dannjjm 291 17 , , , cord-023095-4dannjjm 291 18 may may MD cord-023095-4dannjjm 291 19 be be VB cord-023095-4dannjjm 291 20 involved involve VBN cord-023095-4dannjjm 291 21 in in IN cord-023095-4dannjjm 291 22 the the DT cord-023095-4dannjjm 291 23 development development NN cord-023095-4dannjjm 291 24 of of IN cord-023095-4dannjjm 291 25 boxer boxer NN cord-023095-4dannjjm 291 26 ARVC ARVC NNP cord-023095-4dannjjm 291 27 , , , cord-023095-4dannjjm 291 28 we -PRON- PRP cord-023095-4dannjjm 291 29 hypothesized hypothesize VBD cord-023095-4dannjjm 291 30 that that IN cord-023095-4dannjjm 291 31 changes change NNS cord-023095-4dannjjm 291 32 in in IN cord-023095-4dannjjm 291 33 the the DT cord-023095-4dannjjm 291 34 Wnt Wnt NNP cord-023095-4dannjjm 291 35 pathway pathway NN cord-023095-4dannjjm 291 36 may may MD cord-023095-4dannjjm 291 37 also also RB cord-023095-4dannjjm 291 38 play play VB cord-023095-4dannjjm 291 39 a a DT cord-023095-4dannjjm 291 40 role role NN cord-023095-4dannjjm 291 41 in in IN cord-023095-4dannjjm 291 42 the the DT cord-023095-4dannjjm 291 43 etiology etiology NN cord-023095-4dannjjm 291 44 . . . cord-023095-4dannjjm 292 1 Here here RB cord-023095-4dannjjm 292 2 , , , cord-023095-4dannjjm 292 3 we -PRON- PRP cord-023095-4dannjjm 292 4 show show VBP cord-023095-4dannjjm 292 5 changes change NNS cord-023095-4dannjjm 292 6 in in IN cord-023095-4dannjjm 292 7 the the DT cord-023095-4dannjjm 292 8 localization localization NN cord-023095-4dannjjm 292 9 and and CC cord-023095-4dannjjm 292 10 decreased decrease VBN cord-023095-4dannjjm 292 11 amount amount NN cord-023095-4dannjjm 292 12 of of IN cord-023095-4dannjjm 292 13 proteins protein NNS cord-023095-4dannjjm 292 14 affiliated affiliate VBN cord-023095-4dannjjm 292 15 with with IN cord-023095-4dannjjm 292 16 the the DT cord-023095-4dannjjm 292 17 canonical canonical JJ cord-023095-4dannjjm 292 18 Wnt Wnt NNP cord-023095-4dannjjm 292 19 pathway pathway NN cord-023095-4dannjjm 292 20 . . . cord-023095-4dannjjm 293 1 Afflicted afflicted JJ cord-023095-4dannjjm 293 2 boxers boxer NNS cord-023095-4dannjjm 293 3 were be VBD cord-023095-4dannjjm 293 4 identified identify VBN cord-023095-4dannjjm 293 5 by by IN cord-023095-4dannjjm 293 6 24-hour 24-hour JJ cord-023095-4dannjjm 293 7 Holter Holter NNP cord-023095-4dannjjm 293 8 monitoring monitoring NN cord-023095-4dannjjm 293 9 and and CC cord-023095-4dannjjm 293 10 histopathological histopathological JJ cord-023095-4dannjjm 293 11 examination examination NN cord-023095-4dannjjm 293 12 of of IN cord-023095-4dannjjm 293 13 the the DT cord-023095-4dannjjm 293 14 heart heart NN cord-023095-4dannjjm 293 15 . . . cord-023095-4dannjjm 294 1 Samples sample NNS cord-023095-4dannjjm 294 2 from from IN cord-023095-4dannjjm 294 3 the the DT cord-023095-4dannjjm 294 4 right right JJ cord-023095-4dannjjm 294 5 ventricle ventricle NN cord-023095-4dannjjm 294 6 RV RV NNP cord-023095-4dannjjm 294 7 ) ) -RRB- cord-023095-4dannjjm 294 8 of of IN cord-023095-4dannjjm 294 9 15 15 CD cord-023095-4dannjjm 294 10 ARVC ARVC NNP cord-023095-4dannjjm 294 11 afflicted afflict VBN cord-023095-4dannjjm 294 12 boxers boxer NNS cord-023095-4dannjjm 294 13 , , , cord-023095-4dannjjm 294 14 and and CC cord-023095-4dannjjm 294 15 5 5 CD cord-023095-4dannjjm 294 16 unafflicted unafflicted JJ cord-023095-4dannjjm 294 17 dogs dog NNS cord-023095-4dannjjm 294 18 ( ( -LRB- cord-023095-4dannjjm 294 19 1 1 CD cord-023095-4dannjjm 294 20 beagle beagle NN cord-023095-4dannjjm 294 21 , , , cord-023095-4dannjjm 294 22 2 2 CD cord-023095-4dannjjm 294 23 mongrels mongrel NNS cord-023095-4dannjjm 294 24 , , , cord-023095-4dannjjm 294 25 and and CC cord-023095-4dannjjm 294 26 2 2 CD cord-023095-4dannjjm 294 27 German german JJ cord-023095-4dannjjm 294 28 shepherds shepherd NNS cord-023095-4dannjjm 294 29 ) ) -RRB- cord-023095-4dannjjm 294 30 were be VBD cord-023095-4dannjjm 294 31 collected collect VBN cord-023095-4dannjjm 294 32 , , , cord-023095-4dannjjm 294 33 fixed fix VBN cord-023095-4dannjjm 294 34 in in IN cord-023095-4dannjjm 294 35 10 10 CD cord-023095-4dannjjm 294 36 % % NN cord-023095-4dannjjm 294 37 formalin formalin NN cord-023095-4dannjjm 294 38 , , , cord-023095-4dannjjm 294 39 processed process VBN cord-023095-4dannjjm 294 40 , , , cord-023095-4dannjjm 294 41 treated treat VBN cord-023095-4dannjjm 294 42 with with IN cord-023095-4dannjjm 294 43 antibodies antibody NNS cord-023095-4dannjjm 294 44 recognizingcatenin recognizingcatenin NNS cord-023095-4dannjjm 294 45 , , , cord-023095-4dannjjm 294 46 striatin striatin NN cord-023095-4dannjjm 294 47 , , , cord-023095-4dannjjm 294 48 and and CC cord-023095-4dannjjm 294 49 calnexin calnexin NN cord-023095-4dannjjm 294 50 , , , cord-023095-4dannjjm 294 51 and and CC cord-023095-4dannjjm 294 52 examined examine VBD cord-023095-4dannjjm 294 53 using use VBG cord-023095-4dannjjm 294 54 confocal confocal JJ cord-023095-4dannjjm 294 55 microscopy microscopy NNS cord-023095-4dannjjm 294 56 . . . cord-023095-4dannjjm 295 1 Western western JJ cord-023095-4dannjjm 295 2 blots blot NNS cord-023095-4dannjjm 295 3 were be VBD cord-023095-4dannjjm 295 4 performed perform VBN cord-023095-4dannjjm 295 5 on on IN cord-023095-4dannjjm 295 6 3 3 CD cord-023095-4dannjjm 295 7 unafflicted unafflicted JJ cord-023095-4dannjjm 295 8 RV rv NN cord-023095-4dannjjm 295 9 samples sample NNS cord-023095-4dannjjm 295 10 , , , cord-023095-4dannjjm 295 11 and and CC cord-023095-4dannjjm 295 12 2 2 CD cord-023095-4dannjjm 295 13 ARVC ARVC NNP cord-023095-4dannjjm 295 14 afflicted afflict VBN cord-023095-4dannjjm 295 15 RV RV NNP cord-023095-4dannjjm 295 16 samples sample NNS cord-023095-4dannjjm 295 17 . . . cord-023095-4dannjjm 296 1 Frozen frozen JJ cord-023095-4dannjjm 296 2 tissue tissue NN cord-023095-4dannjjm 296 3 samples sample NNS cord-023095-4dannjjm 296 4 were be VBD cord-023095-4dannjjm 296 5 homogenized homogenize VBN cord-023095-4dannjjm 296 6 in in IN cord-023095-4dannjjm 296 7 Laemmli Laemmli NNP cord-023095-4dannjjm 296 8 buffer buffer NN cord-023095-4dannjjm 296 9 , , , cord-023095-4dannjjm 296 10 and and CC cord-023095-4dannjjm 296 11 10 10 CD cord-023095-4dannjjm 296 12 mg mg NNS cord-023095-4dannjjm 296 13 of of IN cord-023095-4dannjjm 296 14 protein protein NN cord-023095-4dannjjm 296 15 was be VBD cord-023095-4dannjjm 296 16 loaded load VBN cord-023095-4dannjjm 296 17 into into IN cord-023095-4dannjjm 296 18 each each DT cord-023095-4dannjjm 296 19 well well NN cord-023095-4dannjjm 296 20 of of IN cord-023095-4dannjjm 296 21 a a DT cord-023095-4dannjjm 296 22 8 8 CD cord-023095-4dannjjm 296 23 - - SYM cord-023095-4dannjjm 296 24 16 16 CD cord-023095-4dannjjm 296 25 % % NN cord-023095-4dannjjm 296 26 gradient gradient NN cord-023095-4dannjjm 296 27 gel gel NN cord-023095-4dannjjm 296 28 . . . cord-023095-4dannjjm 297 1 -catenin -catenin : cord-023095-4dannjjm 297 2 , , , cord-023095-4dannjjm 297 3 an an DT cord-023095-4dannjjm 297 4 integral integral JJ cord-023095-4dannjjm 297 5 modulator modulator NN cord-023095-4dannjjm 297 6 of of IN cord-023095-4dannjjm 297 7 the the DT cord-023095-4dannjjm 297 8 Wnt Wnt NNP cord-023095-4dannjjm 297 9 pathway pathway NN cord-023095-4dannjjm 297 10 , , , cord-023095-4dannjjm 297 11 and and CC cord-023095-4dannjjm 297 12 striatin striatin NNS cord-023095-4dannjjm 297 13 were be VBD cord-023095-4dannjjm 297 14 colocalized colocalize VBN cord-023095-4dannjjm 297 15 with with IN cord-023095-4dannjjm 297 16 the the DT cord-023095-4dannjjm 297 17 endoplasmic endoplasmic NN cord-023095-4dannjjm 297 18 reticulum reticulum NN cord-023095-4dannjjm 297 19 ( ( -LRB- cord-023095-4dannjjm 297 20 ER ER NNP cord-023095-4dannjjm 297 21 ) ) -RRB- cord-023095-4dannjjm 297 22 marker marker NN cord-023095-4dannjjm 297 23 , , , cord-023095-4dannjjm 297 24 calnexin calnexin NNP cord-023095-4dannjjm 297 25 . . . cord-023095-4dannjjm 298 1 In in IN cord-023095-4dannjjm 298 2 the the DT cord-023095-4dannjjm 298 3 unafflicted unafflicted JJ cord-023095-4dannjjm 298 4 animals animal NNS cord-023095-4dannjjm 298 5 , , , cord-023095-4dannjjm 298 6 -catenin -catenin : cord-023095-4dannjjm 298 7 localized localize VBN cord-023095-4dannjjm 298 8 at at IN cord-023095-4dannjjm 298 9 sites site NNS cord-023095-4dannjjm 298 10 of of IN cord-023095-4dannjjm 298 11 cell cell NN cord-023095-4dannjjm 298 12 - - HYPH cord-023095-4dannjjm 298 13 to to IN cord-023095-4dannjjm 298 14 - - HYPH cord-023095-4dannjjm 298 15 cell cell NN cord-023095-4dannjjm 298 16 apposition apposition NN cord-023095-4dannjjm 298 17 , , , cord-023095-4dannjjm 298 18 and and CC cord-023095-4dannjjm 298 19 striatin striatin NN cord-023095-4dannjjm 298 20 localized localize VBN cord-023095-4dannjjm 298 21 in in IN cord-023095-4dannjjm 298 22 a a DT cord-023095-4dannjjm 298 23 diffuse diffuse JJ cord-023095-4dannjjm 298 24 intracellular intracellular JJ cord-023095-4dannjjm 298 25 pattern pattern NN cord-023095-4dannjjm 298 26 , , , cord-023095-4dannjjm 298 27 with with IN cord-023095-4dannjjm 298 28 no no DT cord-023095-4dannjjm 298 29 detectable detectable JJ cord-023095-4dannjjm 298 30 localization localization NN cord-023095-4dannjjm 298 31 in in IN cord-023095-4dannjjm 298 32 the the DT cord-023095-4dannjjm 298 33 ER er NN cord-023095-4dannjjm 298 34 . . . cord-023095-4dannjjm 299 1 In in IN cord-023095-4dannjjm 299 2 contrast contrast NN cord-023095-4dannjjm 299 3 , , , cord-023095-4dannjjm 299 4 in in IN cord-023095-4dannjjm 299 5 the the DT cord-023095-4dannjjm 299 6 15 15 CD cord-023095-4dannjjm 299 7 ARVC ARVC NNP cord-023095-4dannjjm 299 8 boxers boxer NNS cord-023095-4dannjjm 299 9 , , , cord-023095-4dannjjm 299 10 bothcatenin bothcatenin NNP cord-023095-4dannjjm 299 11 and and CC cord-023095-4dannjjm 299 12 striatin striatin NNS cord-023095-4dannjjm 299 13 were be VBD cord-023095-4dannjjm 299 14 colocalized colocalize VBN cord-023095-4dannjjm 299 15 with with IN cord-023095-4dannjjm 299 16 calnexin calnexin NNP cord-023095-4dannjjm 299 17 in in IN cord-023095-4dannjjm 299 18 an an DT cord-023095-4dannjjm 299 19 ER ER NNP cord-023095-4dannjjm 299 20 pattern pattern NN cord-023095-4dannjjm 299 21 . . . cord-023095-4dannjjm 300 1 In in IN cord-023095-4dannjjm 300 2 the the DT cord-023095-4dannjjm 300 3 afflicted afflict VBN cord-023095-4dannjjm 300 4 samples sample NNS cord-023095-4dannjjm 300 5 , , , cord-023095-4dannjjm 300 6 -catenin -catenin : cord-023095-4dannjjm 300 7 and and CC cord-023095-4dannjjm 300 8 striatin striatin NN cord-023095-4dannjjm 300 9 were be VBD cord-023095-4dannjjm 300 10 not not RB cord-023095-4dannjjm 300 11 visualized visualize VBN cord-023095-4dannjjm 300 12 to to IN cord-023095-4dannjjm 300 13 the the DT cord-023095-4dannjjm 300 14 intercalated intercalate VBN cord-023095-4dannjjm 300 15 disc disc NN cord-023095-4dannjjm 300 16 and and CC cord-023095-4dannjjm 300 17 intracellular intracellular JJ cord-023095-4dannjjm 300 18 space space NN cord-023095-4dannjjm 300 19 , , , cord-023095-4dannjjm 300 20 respectively respectively RB cord-023095-4dannjjm 300 21 . . . cord-023095-4dannjjm 301 1 Western western JJ cord-023095-4dannjjm 301 2 blots blot NNS cord-023095-4dannjjm 301 3 of of IN cord-023095-4dannjjm 301 4 striatin striatin NNS cord-023095-4dannjjm 301 5 and and CC cord-023095-4dannjjm 301 6 -catenin -catenin : cord-023095-4dannjjm 301 7 revealed reveal VBD cord-023095-4dannjjm 301 8 no no DT cord-023095-4dannjjm 301 9 changes change NNS cord-023095-4dannjjm 301 10 in in IN cord-023095-4dannjjm 301 11 the the DT cord-023095-4dannjjm 301 12 amount amount NN cord-023095-4dannjjm 301 13 of of IN cord-023095-4dannjjm 301 14 protein protein NN cord-023095-4dannjjm 301 15 . . . cord-023095-4dannjjm 302 1 Interestingly interestingly RB cord-023095-4dannjjm 302 2 , , , cord-023095-4dannjjm 302 3 a a DT cord-023095-4dannjjm 302 4 Western western JJ cord-023095-4dannjjm 302 5 blot blot NN cord-023095-4dannjjm 302 6 for for IN cord-023095-4dannjjm 302 7 the the DT cord-023095-4dannjjm 302 8 Wnt Wnt NNP cord-023095-4dannjjm 302 9 protein protein NN cord-023095-4dannjjm 302 10 revealed reveal VBD cord-023095-4dannjjm 302 11 a a DT cord-023095-4dannjjm 302 12 decrease decrease NN cord-023095-4dannjjm 302 13 in in IN cord-023095-4dannjjm 302 14 the the DT cord-023095-4dannjjm 302 15 amount amount NN cord-023095-4dannjjm 302 16 of of IN cord-023095-4dannjjm 302 17 protein protein NN cord-023095-4dannjjm 302 18 in in IN cord-023095-4dannjjm 302 19 ARVC ARVC NNP cord-023095-4dannjjm 302 20 samples sample NNS cord-023095-4dannjjm 302 21 , , , cord-023095-4dannjjm 302 22 compared compare VBN cord-023095-4dannjjm 302 23 to to IN cord-023095-4dannjjm 302 24 unafflicted unafflicted JJ cord-023095-4dannjjm 302 25 samples sample NNS cord-023095-4dannjjm 302 26 . . . cord-023095-4dannjjm 303 1 Our -PRON- PRP$ cord-023095-4dannjjm 303 2 preliminary preliminary JJ cord-023095-4dannjjm 303 3 data datum NNS cord-023095-4dannjjm 303 4 suggest suggest VBP cord-023095-4dannjjm 303 5 that that IN cord-023095-4dannjjm 303 6 disturbances disturbance NNS cord-023095-4dannjjm 303 7 of of IN cord-023095-4dannjjm 303 8 the the DT cord-023095-4dannjjm 303 9 canonical canonical JJ cord-023095-4dannjjm 303 10 Wnt Wnt NNP cord-023095-4dannjjm 303 11 pathway pathway NN cord-023095-4dannjjm 303 12 may may MD cord-023095-4dannjjm 303 13 play play VB cord-023095-4dannjjm 303 14 an an DT cord-023095-4dannjjm 303 15 etiological etiological JJ cord-023095-4dannjjm 303 16 role role NN cord-023095-4dannjjm 303 17 in in IN cord-023095-4dannjjm 303 18 the the DT cord-023095-4dannjjm 303 19 development development NN cord-023095-4dannjjm 303 20 of of IN cord-023095-4dannjjm 303 21 ARVC ARVC NNP cord-023095-4dannjjm 303 22 in in IN cord-023095-4dannjjm 303 23 the the DT cord-023095-4dannjjm 303 24 boxer boxer NN cord-023095-4dannjjm 303 25 dog dog NN cord-023095-4dannjjm 303 26 . . . cord-023095-4dannjjm 304 1 There there EX cord-023095-4dannjjm 304 2 are be VBP cord-023095-4dannjjm 304 3 numerous numerous JJ cord-023095-4dannjjm 304 4 benefits benefit NNS cord-023095-4dannjjm 304 5 of of IN cord-023095-4dannjjm 304 6 omega-3 omega-3 NN cord-023095-4dannjjm 304 7 fatty fatty JJ cord-023095-4dannjjm 304 8 acid acid NN cord-023095-4dannjjm 304 9 supplementation supplementation NN cord-023095-4dannjjm 304 10 in in IN cord-023095-4dannjjm 304 11 human human JJ cord-023095-4dannjjm 304 12 heart heart NN cord-023095-4dannjjm 304 13 disease disease NN cord-023095-4dannjjm 304 14 , , , cord-023095-4dannjjm 304 15 including include VBG cord-023095-4dannjjm 304 16 reduction reduction NN cord-023095-4dannjjm 304 17 in in IN cord-023095-4dannjjm 304 18 arrhythmias arrhythmia NNS cord-023095-4dannjjm 304 19 , , , cord-023095-4dannjjm 304 20 decreased decrease VBD cord-023095-4dannjjm 304 21 incidence incidence NN cord-023095-4dannjjm 304 22 of of IN cord-023095-4dannjjm 304 23 sudden sudden JJ cord-023095-4dannjjm 304 24 death death NN cord-023095-4dannjjm 304 25 , , , cord-023095-4dannjjm 304 26 and and CC cord-023095-4dannjjm 304 27 improved improve VBN cord-023095-4dannjjm 304 28 survival survival NN cord-023095-4dannjjm 304 29 in in IN cord-023095-4dannjjm 304 30 heart heart NN cord-023095-4dannjjm 304 31 failure failure NN cord-023095-4dannjjm 304 32 . . . cord-023095-4dannjjm 305 1 Antithrombotic antithrombotic JJ cord-023095-4dannjjm 305 2 effects effect NNS cord-023095-4dannjjm 305 3 of of IN cord-023095-4dannjjm 305 4 omega-3 omega-3 NN cord-023095-4dannjjm 305 5 fatty fatty JJ cord-023095-4dannjjm 305 6 acids acid NNS cord-023095-4dannjjm 305 7 have have VBP cord-023095-4dannjjm 305 8 been be VBN cord-023095-4dannjjm 305 9 demonstrated demonstrate VBN cord-023095-4dannjjm 305 10 in in IN cord-023095-4dannjjm 305 11 people people NNS cord-023095-4dannjjm 305 12 , , , cord-023095-4dannjjm 305 13 which which WDT cord-023095-4dannjjm 305 14 may may MD cord-023095-4dannjjm 305 15 have have VB cord-023095-4dannjjm 305 16 particular particular JJ cord-023095-4dannjjm 305 17 benefit benefit NN cord-023095-4dannjjm 305 18 in in IN cord-023095-4dannjjm 305 19 cats cat NNS cord-023095-4dannjjm 305 20 given give VBN cord-023095-4dannjjm 305 21 their -PRON- PRP$ cord-023095-4dannjjm 305 22 risk risk NN cord-023095-4dannjjm 305 23 of of IN cord-023095-4dannjjm 305 24 thromboembolic thromboembolic JJ cord-023095-4dannjjm 305 25 complications complication NNS cord-023095-4dannjjm 305 26 with with IN cord-023095-4dannjjm 305 27 cardiac cardiac JJ cord-023095-4dannjjm 305 28 disease disease NN cord-023095-4dannjjm 305 29 . . . cord-023095-4dannjjm 306 1 Benefits benefit NNS cord-023095-4dannjjm 306 2 also also RB cord-023095-4dannjjm 306 3 have have VBP cord-023095-4dannjjm 306 4 been be VBN cord-023095-4dannjjm 306 5 found find VBN cord-023095-4dannjjm 306 6 in in IN cord-023095-4dannjjm 306 7 canine canine JJ cord-023095-4dannjjm 306 8 heart heart NN cord-023095-4dannjjm 306 9 disease disease NN cord-023095-4dannjjm 306 10 , , , cord-023095-4dannjjm 306 11 and and CC cord-023095-4dannjjm 306 12 reduced reduced JJ cord-023095-4dannjjm 306 13 serum serum NN cord-023095-4dannjjm 306 14 concentrations concentration NNS cord-023095-4dannjjm 306 15 of of IN cord-023095-4dannjjm 306 16 the the DT cord-023095-4dannjjm 306 17 omega-3 omega-3 NN cord-023095-4dannjjm 306 18 fatty fatty JJ cord-023095-4dannjjm 306 19 acids acid NNS cord-023095-4dannjjm 306 20 , , , cord-023095-4dannjjm 306 21 eicosapentaenoic eicosapentaenoic NN cord-023095-4dannjjm 306 22 acid acid NN cord-023095-4dannjjm 306 23 ( ( -LRB- cord-023095-4dannjjm 306 24 EPA EPA NNP cord-023095-4dannjjm 306 25 ) ) -RRB- cord-023095-4dannjjm 306 26 and and CC cord-023095-4dannjjm 306 27 docosahexaenoic docosahexaenoic NNP cord-023095-4dannjjm 306 28 acid acid NNP cord-023095-4dannjjm 306 29 ( ( -LRB- cord-023095-4dannjjm 306 30 DHA DHA NNP cord-023095-4dannjjm 306 31 ) ) -RRB- cord-023095-4dannjjm 306 32 have have VBP cord-023095-4dannjjm 306 33 been be VBN cord-023095-4dannjjm 306 34 found find VBN cord-023095-4dannjjm 306 35 in in IN cord-023095-4dannjjm 306 36 dogs dog NNS cord-023095-4dannjjm 306 37 with with IN cord-023095-4dannjjm 306 38 congestive congestive JJ cord-023095-4dannjjm 306 39 heart heart NN cord-023095-4dannjjm 306 40 failure failure NN cord-023095-4dannjjm 306 41 ( ( -LRB- cord-023095-4dannjjm 306 42 CHF CHF NNP cord-023095-4dannjjm 306 43 ) ) -RRB- cord-023095-4dannjjm 306 44 secondary secondary JJ cord-023095-4dannjjm 306 45 to to IN cord-023095-4dannjjm 306 46 DCM DCM NNP cord-023095-4dannjjm 306 47 . . . cord-023095-4dannjjm 307 1 To to IN cord-023095-4dannjjm 307 2 the the DT cord-023095-4dannjjm 307 3 authors author NNS cord-023095-4dannjjm 307 4 ' ' POS cord-023095-4dannjjm 307 5 knowledge knowledge NN cord-023095-4dannjjm 307 6 , , , cord-023095-4dannjjm 307 7 no no DT cord-023095-4dannjjm 307 8 studies study NNS cord-023095-4dannjjm 307 9 to to IN cord-023095-4dannjjm 307 10 date date NN cord-023095-4dannjjm 307 11 have have VBP cord-023095-4dannjjm 307 12 investigated investigate VBN cord-023095-4dannjjm 307 13 fatty fatty JJ cord-023095-4dannjjm 307 14 acid acid NN cord-023095-4dannjjm 307 15 concentrations concentration NNS cord-023095-4dannjjm 307 16 in in IN cord-023095-4dannjjm 307 17 cats cat NNS cord-023095-4dannjjm 307 18 with with IN cord-023095-4dannjjm 307 19 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 307 20 . . . cord-023095-4dannjjm 308 1 The the DT cord-023095-4dannjjm 308 2 purpose purpose NN cord-023095-4dannjjm 308 3 of of IN cord-023095-4dannjjm 308 4 this this DT cord-023095-4dannjjm 308 5 study study NN cord-023095-4dannjjm 308 6 was be VBD cord-023095-4dannjjm 308 7 to to TO cord-023095-4dannjjm 308 8 measure measure VB cord-023095-4dannjjm 308 9 serum serum JJ cord-023095-4dannjjm 308 10 fatty fatty JJ cord-023095-4dannjjm 308 11 acid acid NN cord-023095-4dannjjm 308 12 concentrations concentration NNS cord-023095-4dannjjm 308 13 in in IN cord-023095-4dannjjm 308 14 normal normal JJ cord-023095-4dannjjm 308 15 cats cat NNS cord-023095-4dannjjm 308 16 and and CC cord-023095-4dannjjm 308 17 cats cat NNS cord-023095-4dannjjm 308 18 with with IN cord-023095-4dannjjm 308 19 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 308 20 . . . cord-023095-4dannjjm 309 1 Serum serum NN cord-023095-4dannjjm 309 2 fatty fatty JJ cord-023095-4dannjjm 309 3 acid acid NN cord-023095-4dannjjm 309 4 concentrations concentration NNS cord-023095-4dannjjm 309 5 were be VBD cord-023095-4dannjjm 309 6 measured measure VBN cord-023095-4dannjjm 309 7 in in IN cord-023095-4dannjjm 309 8 normal normal JJ cord-023095-4dannjjm 309 9 cats cat NNS cord-023095-4dannjjm 309 10 and and CC cord-023095-4dannjjm 309 11 cats cat NNS cord-023095-4dannjjm 309 12 with with IN cord-023095-4dannjjm 309 13 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 309 14 using use VBG cord-023095-4dannjjm 309 15 gas gas NN cord-023095-4dannjjm 309 16 chromatography chromatography NN cord-023095-4dannjjm 309 17 . . . cord-023095-4dannjjm 310 1 Cats cat NNS cord-023095-4dannjjm 310 2 with with IN cord-023095-4dannjjm 310 3 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 310 4 and and CC cord-023095-4dannjjm 310 5 at at IN cord-023095-4dannjjm 310 6 least least JJS cord-023095-4dannjjm 310 7 mild mild JJ cord-023095-4dannjjm 310 8 left left JJ cord-023095-4dannjjm 310 9 atrial atrial NN cord-023095-4dannjjm 310 10 ( ( -LRB- cord-023095-4dannjjm 310 11 LA LA NNP cord-023095-4dannjjm 310 12 ) ) -RRB- cord-023095-4dannjjm 310 13 enlargement enlargement NN cord-023095-4dannjjm 310 14 ( ( -LRB- cord-023095-4dannjjm 310 15 LA LA NNP cord-023095-4dannjjm 310 16 to to IN cord-023095-4dannjjm 310 17 aortic aortic JJ cord-023095-4dannjjm 310 18 ratio ratio NN cord-023095-4dannjjm 310 19 4 4 CD cord-023095-4dannjjm 310 20 1.5 1.5 CD cord-023095-4dannjjm 310 21 on on IN cord-023095-4dannjjm 310 22 two two CD cord-023095-4dannjjm 310 23 - - HYPH cord-023095-4dannjjm 310 24 dimensional dimensional JJ cord-023095-4dannjjm 310 25 echocardiography echocardiography NN cord-023095-4dannjjm 310 26 from from IN cord-023095-4dannjjm 310 27 a a DT cord-023095-4dannjjm 310 28 right right JJ cord-023095-4dannjjm 310 29 parasternal parasternal JJ cord-023095-4dannjjm 310 30 short short JJ cord-023095-4dannjjm 310 31 axis axis NN cord-023095-4dannjjm 310 32 view view NN cord-023095-4dannjjm 310 33 ) ) -RRB- cord-023095-4dannjjm 310 34 were be VBD cord-023095-4dannjjm 310 35 candidates candidate NNS cord-023095-4dannjjm 310 36 for for IN cord-023095-4dannjjm 310 37 study study NN cord-023095-4dannjjm 310 38 . . . cord-023095-4dannjjm 311 1 Normal normal JJ cord-023095-4dannjjm 311 2 cats cat NNS cord-023095-4dannjjm 311 3 had have VBD cord-023095-4dannjjm 311 4 a a DT cord-023095-4dannjjm 311 5 normal normal JJ cord-023095-4dannjjm 311 6 history history NN cord-023095-4dannjjm 311 7 , , , cord-023095-4dannjjm 311 8 physical physical JJ cord-023095-4dannjjm 311 9 examination examination NN cord-023095-4dannjjm 311 10 , , , cord-023095-4dannjjm 311 11 echocardiogram echocardiogram NN cord-023095-4dannjjm 311 12 , , , cord-023095-4dannjjm 311 13 packed pack VBN cord-023095-4dannjjm 311 14 cell cell NN cord-023095-4dannjjm 311 15 volume volume NN cord-023095-4dannjjm 311 16 , , , cord-023095-4dannjjm 311 17 total total JJ cord-023095-4dannjjm 311 18 solids solid NNS cord-023095-4dannjjm 311 19 and and CC cord-023095-4dannjjm 311 20 platelet platelet NN cord-023095-4dannjjm 311 21 count count NN cord-023095-4dannjjm 311 22 . . . cord-023095-4dannjjm 312 1 Cats cat NNS cord-023095-4dannjjm 312 2 with with IN cord-023095-4dannjjm 312 3 evidence evidence NN cord-023095-4dannjjm 312 4 of of IN cord-023095-4dannjjm 312 5 other other JJ cord-023095-4dannjjm 312 6 systemic systemic JJ cord-023095-4dannjjm 312 7 disease disease NN cord-023095-4dannjjm 312 8 or or CC cord-023095-4dannjjm 312 9 those those DT cord-023095-4dannjjm 312 10 receiving receive VBG cord-023095-4dannjjm 312 11 anticoagulants anticoagulant NNS cord-023095-4dannjjm 312 12 were be VBD cord-023095-4dannjjm 312 13 excluded exclude VBN cord-023095-4dannjjm 312 14 from from IN cord-023095-4dannjjm 312 15 the the DT cord-023095-4dannjjm 312 16 study study NN cord-023095-4dannjjm 312 17 . . . cord-023095-4dannjjm 313 1 Normally normally RB cord-023095-4dannjjm 313 2 distributed distributed JJ cord-023095-4dannjjm 313 3 and and CC cord-023095-4dannjjm 313 4 skewed skewed JJ cord-023095-4dannjjm 313 5 data datum NNS cord-023095-4dannjjm 313 6 were be VBD cord-023095-4dannjjm 313 7 compared compare VBN cord-023095-4dannjjm 313 8 between between IN cord-023095-4dannjjm 313 9 the the DT cord-023095-4dannjjm 313 10 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 313 11 and and CC cord-023095-4dannjjm 313 12 control control NN cord-023095-4dannjjm 313 13 groups group NNS cord-023095-4dannjjm 313 14 with with IN cord-023095-4dannjjm 313 15 independent independent JJ cord-023095-4dannjjm 313 16 t t NN cord-023095-4dannjjm 313 17 tests test NNS cord-023095-4dannjjm 313 18 or or CC cord-023095-4dannjjm 313 19 Mann Mann NNP cord-023095-4dannjjm 313 20 Whitney Whitney NNP cord-023095-4dannjjm 313 21 U U NNP cord-023095-4dannjjm 313 22 tests test NNS cord-023095-4dannjjm 313 23 , , , cord-023095-4dannjjm 313 24 respectively respectively RB cord-023095-4dannjjm 313 25 . . . cord-023095-4dannjjm 314 1 Statistical statistical JJ cord-023095-4dannjjm 314 2 significance significance NN cord-023095-4dannjjm 314 3 was be VBD cord-023095-4dannjjm 314 4 set set VBN cord-023095-4dannjjm 314 5 at at IN cord-023095-4dannjjm 314 6 P p NN cord-023095-4dannjjm 314 7 o o NN cord-023095-4dannjjm 314 8 0.01 0.01 CD cord-023095-4dannjjm 314 9 . . . cord-023095-4dannjjm 315 1 Thirty thirty CD cord-023095-4dannjjm 315 2 cats cat NNS cord-023095-4dannjjm 315 3 with with IN cord-023095-4dannjjm 315 4 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 315 5 ( ( -LRB- cord-023095-4dannjjm 315 6 23 23 CD cord-023095-4dannjjm 315 7 neutered neutered JJ cord-023095-4dannjjm 315 8 males male NNS cord-023095-4dannjjm 315 9 and and CC cord-023095-4dannjjm 315 10 7 7 CD cord-023095-4dannjjm 315 11 neutered neutered JJ cord-023095-4dannjjm 315 12 females female NNS cord-023095-4dannjjm 315 13 ) ) -RRB- cord-023095-4dannjjm 315 14 and and CC cord-023095-4dannjjm 315 15 27 27 CD cord-023095-4dannjjm 315 16 healthy healthy JJ cord-023095-4dannjjm 315 17 controls control NNS cord-023095-4dannjjm 315 18 ( ( -LRB- cord-023095-4dannjjm 315 19 13 13 CD cord-023095-4dannjjm 315 20 neutered neutered JJ cord-023095-4dannjjm 315 21 males male NNS cord-023095-4dannjjm 315 22 and and CC cord-023095-4dannjjm 315 23 14 14 CD cord-023095-4dannjjm 315 24 neutered neutered JJ cord-023095-4dannjjm 315 25 females female NNS cord-023095-4dannjjm 315 26 ) ) -RRB- cord-023095-4dannjjm 315 27 were be VBD cord-023095-4dannjjm 315 28 enrolled enrol VBN cord-023095-4dannjjm 315 29 . . . cord-023095-4dannjjm 316 1 Median median JJ cord-023095-4dannjjm 316 2 age age NN cord-023095-4dannjjm 316 3 was be VBD cord-023095-4dannjjm 316 4 8 8 CD cord-023095-4dannjjm 316 5 yr yr NN cord-023095-4dannjjm 316 6 ( ( -LRB- cord-023095-4dannjjm 316 7 range range NN cord-023095-4dannjjm 316 8 , , , cord-023095-4dannjjm 316 9 2 2 CD cord-023095-4dannjjm 316 10 - - SYM cord-023095-4dannjjm 316 11 16 16 CD cord-023095-4dannjjm 316 12 yr yr NN cord-023095-4dannjjm 316 13 ) ) -RRB- cord-023095-4dannjjm 316 14 in in IN cord-023095-4dannjjm 316 15 the the DT cord-023095-4dannjjm 316 16 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 316 17 group group NN cord-023095-4dannjjm 316 18 and and CC cord-023095-4dannjjm 316 19 5 5 CD cord-023095-4dannjjm 316 20 yr yr NN cord-023095-4dannjjm 316 21 ( ( -LRB- cord-023095-4dannjjm 316 22 range range NN cord-023095-4dannjjm 316 23 , , , cord-023095-4dannjjm 316 24 1 1 CD cord-023095-4dannjjm 316 25 - - SYM cord-023095-4dannjjm 316 26 10 10 CD cord-023095-4dannjjm 316 27 yr yr NN cord-023095-4dannjjm 316 28 ) ) -RRB- cord-023095-4dannjjm 316 29 in in IN cord-023095-4dannjjm 316 30 the the DT cord-023095-4dannjjm 316 31 control control NN cord-023095-4dannjjm 316 32 group group NN cord-023095-4dannjjm 316 33 ( ( -LRB- cord-023095-4dannjjm 316 34 P p NN cord-023095-4dannjjm 316 35 5 5 CD cord-023095-4dannjjm 316 36 .009 .009 CD cord-023095-4dannjjm 316 37 ) ) -RRB- cord-023095-4dannjjm 316 38 . . . cord-023095-4dannjjm 317 1 Cats cat NNS cord-023095-4dannjjm 317 2 in in IN cord-023095-4dannjjm 317 3 the the DT cord-023095-4dannjjm 317 4 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 317 5 group group NN cord-023095-4dannjjm 317 6 were be VBD cord-023095-4dannjjm 317 7 classified classify VBN cord-023095-4dannjjm 317 8 in in IN cord-023095-4dannjjm 317 9 the the DT cord-023095-4dannjjm 317 10 International International NNP cord-023095-4dannjjm 317 11 Small Small NNP cord-023095-4dannjjm 317 12 Animal Animal NNP cord-023095-4dannjjm 317 13 Cardiac Cardiac NNP cord-023095-4dannjjm 317 14 Health Health NNP cord-023095-4dannjjm 317 15 Council Council NNP cord-023095-4dannjjm 317 16 stage stage NN cord-023095-4dannjjm 317 17 1b 1b CD cord-023095-4dannjjm 317 18 ( ( -LRB- cord-023095-4dannjjm 317 19 n n NN cord-023095-4dannjjm 317 20 5 5 CD cord-023095-4dannjjm 317 21 10 10 CD cord-023095-4dannjjm 317 22 ) ) -RRB- cord-023095-4dannjjm 317 23 , , , cord-023095-4dannjjm 317 24 2 2 CD cord-023095-4dannjjm 317 25 ( ( -LRB- cord-023095-4dannjjm 317 26 n n NN cord-023095-4dannjjm 317 27 5 5 CD cord-023095-4dannjjm 317 28 8) 8) NNP cord-023095-4dannjjm 317 29 , , , cord-023095-4dannjjm 317 30 3a 3a NNP cord-023095-4dannjjm 317 31 ( ( -LRB- cord-023095-4dannjjm 317 32 n n NN cord-023095-4dannjjm 317 33 5 5 CD cord-023095-4dannjjm 317 34 3 3 CD cord-023095-4dannjjm 317 35 ) ) -RRB- cord-023095-4dannjjm 317 36 and and CC cord-023095-4dannjjm 317 37 3b 3b LS cord-023095-4dannjjm 317 38 ( ( -LRB- cord-023095-4dannjjm 317 39 n n NN cord-023095-4dannjjm 317 40 5 5 CD cord-023095-4dannjjm 317 41 9 9 CD cord-023095-4dannjjm 317 42 ) ) -RRB- cord-023095-4dannjjm 317 43 . . . cord-023095-4dannjjm 318 1 Compared compare VBN cord-023095-4dannjjm 318 2 to to TO cord-023095-4dannjjm 318 3 control control VB cord-023095-4dannjjm 318 4 cats cat NNS cord-023095-4dannjjm 318 5 , , , cord-023095-4dannjjm 318 6 cardiomyopathic cardiomyopathic NNP cord-023095-4dannjjm 318 7 cats cat NNS cord-023095-4dannjjm 318 8 had have VBD cord-023095-4dannjjm 318 9 higher high JJR cord-023095-4dannjjm 318 10 concentrations concentration NNS cord-023095-4dannjjm 318 11 of of IN cord-023095-4dannjjm 318 12 palmitic palmitic JJ cord-023095-4dannjjm 318 13 acid acid NN cord-023095-4dannjjm 318 14 ( ( -LRB- cord-023095-4dannjjm 318 15 P p NN cord-023095-4dannjjm 318 16 5 5 CD cord-023095-4dannjjm 318 17 .002 .002 NFP cord-023095-4dannjjm 318 18 ) ) -RRB- cord-023095-4dannjjm 318 19 and and CC cord-023095-4dannjjm 318 20 DHA DHA NNP cord-023095-4dannjjm 318 21 ( ( -LRB- cord-023095-4dannjjm 318 22 P p NN cord-023095-4dannjjm 318 23 o o NN cord-023095-4dannjjm 318 24 .001 .001 CD cord-023095-4dannjjm 318 25 ) ) -RRB- cord-023095-4dannjjm 318 26 , , , cord-023095-4dannjjm 318 27 and and CC cord-023095-4dannjjm 318 28 lower low JJR cord-023095-4dannjjm 318 29 concentrations concentration NNS cord-023095-4dannjjm 318 30 of of IN cord-023095-4dannjjm 318 31 linoleic linoleic JJ cord-023095-4dannjjm 318 32 acid acid NN cord-023095-4dannjjm 318 33 ( ( -LRB- cord-023095-4dannjjm 318 34 P p NN cord-023095-4dannjjm 318 35 5 5 CD cord-023095-4dannjjm 318 36 .005 .005 CD cord-023095-4dannjjm 318 37 ) ) -RRB- cord-023095-4dannjjm 318 38 . . . cord-023095-4dannjjm 319 1 Among among IN cord-023095-4dannjjm 319 2 cats cat NNS cord-023095-4dannjjm 319 3 with with IN cord-023095-4dannjjm 319 4 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 319 5 , , , cord-023095-4dannjjm 319 6 there there EX cord-023095-4dannjjm 319 7 was be VBD cord-023095-4dannjjm 319 8 no no DT cord-023095-4dannjjm 319 9 significant significant JJ cord-023095-4dannjjm 319 10 correlation correlation NN cord-023095-4dannjjm 319 11 between between IN cord-023095-4dannjjm 319 12 any any DT cord-023095-4dannjjm 319 13 serum serum NN cord-023095-4dannjjm 319 14 fatty fatty JJ cord-023095-4dannjjm 319 15 acid acid NN cord-023095-4dannjjm 319 16 concentration concentration NN cord-023095-4dannjjm 319 17 and and CC cord-023095-4dannjjm 319 18 left leave VBN cord-023095-4dannjjm 319 19 atrial atrial JJ cord-023095-4dannjjm 319 20 size size NN cord-023095-4dannjjm 319 21 or or CC cord-023095-4dannjjm 319 22 age age NN cord-023095-4dannjjm 319 23 . . . cord-023095-4dannjjm 320 1 These these DT cord-023095-4dannjjm 320 2 findings finding NNS cord-023095-4dannjjm 320 3 warrant warrant VBP cord-023095-4dannjjm 320 4 further further JJ cord-023095-4dannjjm 320 5 investigation investigation NN cord-023095-4dannjjm 320 6 into into IN cord-023095-4dannjjm 320 7 the the DT cord-023095-4dannjjm 320 8 role role NN cord-023095-4dannjjm 320 9 of of IN cord-023095-4dannjjm 320 10 fatty fatty JJ cord-023095-4dannjjm 320 11 acids acid NNS cord-023095-4dannjjm 320 12 in in IN cord-023095-4dannjjm 320 13 cats cat NNS cord-023095-4dannjjm 320 14 with with IN cord-023095-4dannjjm 320 15 cardiac cardiac JJ cord-023095-4dannjjm 320 16 disease disease NN cord-023095-4dannjjm 320 17 . . . cord-023095-4dannjjm 321 1 Platelet platelet NN cord-023095-4dannjjm 321 2 mapping mapping NN cord-023095-4dannjjm 321 3 is be VBZ cord-023095-4dannjjm 321 4 an an DT cord-023095-4dannjjm 321 5 application application NN cord-023095-4dannjjm 321 6 of of IN cord-023095-4dannjjm 321 7 thromboelastography thromboelastography NNP cord-023095-4dannjjm 321 8 that that WDT cord-023095-4dannjjm 321 9 relies rely VBZ cord-023095-4dannjjm 321 10 on on IN cord-023095-4dannjjm 321 11 the the DT cord-023095-4dannjjm 321 12 generation generation NN cord-023095-4dannjjm 321 13 of of IN cord-023095-4dannjjm 321 14 at at RB cord-023095-4dannjjm 321 15 least least RBS cord-023095-4dannjjm 321 16 three three CD cord-023095-4dannjjm 321 17 tracings tracing NNS cord-023095-4dannjjm 321 18 : : : cord-023095-4dannjjm 321 19 MA MA NNP cord-023095-4dannjjm 321 20 THROMBIN THROMBIN NNP cord-023095-4dannjjm 321 21 ( ( -LRB- cord-023095-4dannjjm 321 22 maximum maximum JJ cord-023095-4dannjjm 321 23 platelet platelet NN cord-023095-4dannjjm 321 24 activity),MA activity),MA NNP cord-023095-4dannjjm 321 25 FIBRIN fibrin NN cord-023095-4dannjjm 321 26 ( ( -LRB- cord-023095-4dannjjm 321 27 fibrin fibrin NN cord-023095-4dannjjm 321 28 activity activity NN cord-023095-4dannjjm 321 29 only only RB cord-023095-4dannjjm 321 30 ) ) -RRB- cord-023095-4dannjjm 321 31 , , , cord-023095-4dannjjm 321 32 an an DT cord-023095-4dannjjm 321 33 - - HYPH cord-023095-4dannjjm 321 34 dMA dma JJ cord-023095-4dannjjm 321 35 AA AA NNP cord-023095-4dannjjm 321 36 or or CC cord-023095-4dannjjm 321 37 ADP ADP NNP cord-023095-4dannjjm 321 38 ( ( -LRB- cord-023095-4dannjjm 321 39 platelet platelet NN cord-023095-4dannjjm 321 40 activity activity NN cord-023095-4dannjjm 321 41 not not RB cord-023095-4dannjjm 321 42 inhibited inhibit VBN cord-023095-4dannjjm 321 43 by by IN cord-023095-4dannjjm 321 44 arachidonic arachidonic JJ cord-023095-4dannjjm 321 45 acid acid NN cord-023095-4dannjjm 321 46 or or CC cord-023095-4dannjjm 321 47 ADP ADP NNP cord-023095-4dannjjm 321 48 receptor receptor NN cord-023095-4dannjjm 321 49 antagonists antagonist NNS cord-023095-4dannjjm 321 50 , , , cord-023095-4dannjjm 321 51 respectively respectively RB cord-023095-4dannjjm 321 52 ) ) -RRB- cord-023095-4dannjjm 321 53 . . . cord-023095-4dannjjm 322 1 Using use VBG cord-023095-4dannjjm 322 2 these these DT cord-023095-4dannjjm 322 3 three three CD cord-023095-4dannjjm 322 4 tracings tracing NNS cord-023095-4dannjjm 322 5 , , , cord-023095-4dannjjm 322 6 the the DT cord-023095-4dannjjm 322 7 % % NN cord-023095-4dannjjm 322 8 inhibition inhibition NN cord-023095-4dannjjm 322 9 of of IN cord-023095-4dannjjm 322 10 platelets platelet NNS cord-023095-4dannjjm 322 11 can can MD cord-023095-4dannjjm 322 12 be be VB cord-023095-4dannjjm 322 13 calculated calculate VBN cord-023095-4dannjjm 322 14 . . . cord-023095-4dannjjm 323 1 The the DT cord-023095-4dannjjm 323 2 purpose purpose NN cord-023095-4dannjjm 323 3 of of IN cord-023095-4dannjjm 323 4 this this DT cord-023095-4dannjjm 323 5 study study NN cord-023095-4dannjjm 323 6 was be VBD cord-023095-4dannjjm 323 7 to to TO cord-023095-4dannjjm 323 8 evaluate evaluate VB cord-023095-4dannjjm 323 9 the the DT cord-023095-4dannjjm 323 10 Platelet Platelet NNP cord-023095-4dannjjm 323 11 Mapping Mapping NNP cord-023095-4dannjjm 323 12 assay assay NN cord-023095-4dannjjm 323 13 in in IN cord-023095-4dannjjm 323 14 normal normal JJ cord-023095-4dannjjm 323 15 cats cat NNS cord-023095-4dannjjm 323 16 and and CC cord-023095-4dannjjm 323 17 assess assess VB cord-023095-4dannjjm 323 18 platelet platelet NN cord-023095-4dannjjm 323 19 inhibition inhibition NN cord-023095-4dannjjm 323 20 in in IN cord-023095-4dannjjm 323 21 cats cat NNS cord-023095-4dannjjm 323 22 receiving receive VBG cord-023095-4dannjjm 323 23 clopidogrel clopidogrel NN cord-023095-4dannjjm 323 24 . . . cord-023095-4dannjjm 324 1 Employee employee NN cord-023095-4dannjjm 324 2 - - HYPH cord-023095-4dannjjm 324 3 owned own VBN cord-023095-4dannjjm 324 4 cats cat NNS cord-023095-4dannjjm 324 5 with with IN cord-023095-4dannjjm 324 6 normal normal JJ cord-023095-4dannjjm 324 7 history history NN cord-023095-4dannjjm 324 8 , , , cord-023095-4dannjjm 324 9 physical physical JJ cord-023095-4dannjjm 324 10 exam exam NN cord-023095-4dannjjm 324 11 , , , cord-023095-4dannjjm 324 12 echocardiogram echocardiogram NN cord-023095-4dannjjm 324 13 , , , cord-023095-4dannjjm 324 14 thromboelastography thromboelastography NNP cord-023095-4dannjjm 324 15 , , , cord-023095-4dannjjm 324 16 packed pack VBN cord-023095-4dannjjm 324 17 cell cell NN cord-023095-4dannjjm 324 18 volume volume NN cord-023095-4dannjjm 324 19 , , , cord-023095-4dannjjm 324 20 total total JJ cord-023095-4dannjjm 324 21 solids solid NNS cord-023095-4dannjjm 324 22 and and CC cord-023095-4dannjjm 324 23 platelet platelet NN cord-023095-4dannjjm 324 24 count count NN cord-023095-4dannjjm 324 25 were be VBD cord-023095-4dannjjm 324 26 eligible eligible JJ cord-023095-4dannjjm 324 27 . . . cord-023095-4dannjjm 325 1 Clopidogrel Clopidogrel NNP cord-023095-4dannjjm 325 2 ( ( -LRB- cord-023095-4dannjjm 325 3 18.75 18.75 CD cord-023095-4dannjjm 325 4 mg mg NNP cord-023095-4dannjjm 325 5 PO PO NNP cord-023095-4dannjjm 325 6 Q24h Q24h NNP cord-023095-4dannjjm 325 7 ) ) -RRB- cord-023095-4dannjjm 325 8 was be VBD cord-023095-4dannjjm 325 9 administered administer VBN cord-023095-4dannjjm 325 10 for for IN cord-023095-4dannjjm 325 11 10 10 CD cord-023095-4dannjjm 325 12 days day NNS cord-023095-4dannjjm 325 13 with with IN cord-023095-4dannjjm 325 14 Platelet platelet NN cord-023095-4dannjjm 325 15 Mapping Mapping NNP cord-023095-4dannjjm 325 16 performed perform VBN cord-023095-4dannjjm 325 17 on on IN cord-023095-4dannjjm 325 18 days day NNS cord-023095-4dannjjm 325 19 0 0 CD cord-023095-4dannjjm 325 20 and and CC cord-023095-4dannjjm 325 21 10 10 CD cord-023095-4dannjjm 325 22 . . . cord-023095-4dannjjm 326 1 Platelet platelet NN cord-023095-4dannjjm 326 2 Mapping mapping NN cord-023095-4dannjjm 326 3 values value NNS cord-023095-4dannjjm 326 4 were be VBD cord-023095-4dannjjm 326 5 compared compare VBN cord-023095-4dannjjm 326 6 using use VBG cord-023095-4dannjjm 326 7 a a DT cord-023095-4dannjjm 326 8 paired paired JJ cord-023095-4dannjjm 326 9 t t NN cord-023095-4dannjjm 326 10 test test NN cord-023095-4dannjjm 326 11 , , , cord-023095-4dannjjm 326 12 with with IN cord-023095-4dannjjm 326 13 significance significance NN cord-023095-4dannjjm 326 14 set set VBN cord-023095-4dannjjm 326 15 at at IN cord-023095-4dannjjm 326 16 P p NN cord-023095-4dannjjm 326 17 o o NN cord-023095-4dannjjm 326 18 0.05 0.05 CD cord-023095-4dannjjm 326 19 . . . cord-023095-4dannjjm 327 1 Seven seven CD cord-023095-4dannjjm 327 2 cats cat NNS cord-023095-4dannjjm 327 3 ( ( -LRB- cord-023095-4dannjjm 327 4 4 4 CD cord-023095-4dannjjm 327 5 FS fs NN cord-023095-4dannjjm 327 6 , , , cord-023095-4dannjjm 327 7 3 3 CD cord-023095-4dannjjm 327 8 CM cm NN cord-023095-4dannjjm 327 9 , , , cord-023095-4dannjjm 327 10 aged aged JJ cord-023095-4dannjjm 327 11 2 2 CD cord-023095-4dannjjm 327 12 - - SYM cord-023095-4dannjjm 327 13 10 10 CD cord-023095-4dannjjm 327 14 years year NNS cord-023095-4dannjjm 327 15 ) ) -RRB- cord-023095-4dannjjm 327 16 were be VBD cord-023095-4dannjjm 327 17 enrolled enrol VBN cord-023095-4dannjjm 327 18 . . . cord-023095-4dannjjm 328 1 Compared compare VBN cord-023095-4dannjjm 328 2 to to IN cord-023095-4dannjjm 328 3 day day NN cord-023095-4dannjjm 328 4 0 0 CD cord-023095-4dannjjm 328 5 , , , cord-023095-4dannjjm 328 6 MA MA NNP cord-023095-4dannjjm 328 7 ADP ADP NNP cord-023095-4dannjjm 328 8 ( ( -LRB- cord-023095-4dannjjm 328 9 P p NN cord-023095-4dannjjm 328 10 o o NN cord-023095-4dannjjm 328 11 .001 .001 CD cord-023095-4dannjjm 328 12 ) ) -RRB- cord-023095-4dannjjm 328 13 and and CC cord-023095-4dannjjm 328 14 MA MA NNP cord-023095-4dannjjm 328 15 FIBRIN FIBRIN NNP cord-023095-4dannjjm 329 1 ( ( -LRB- cord-023095-4dannjjm 329 2 P p NN cord-023095-4dannjjm 329 3 o o NN cord-023095-4dannjjm 329 4 .001 .001 CD cord-023095-4dannjjm 329 5 ) ) -RRB- cord-023095-4dannjjm 329 6 were be VBD cord-023095-4dannjjm 329 7 lower low JJR cord-023095-4dannjjm 329 8 on on IN cord-023095-4dannjjm 329 9 day day NN cord-023095-4dannjjm 329 10 10 10 CD cord-023095-4dannjjm 329 11 . . . cord-023095-4dannjjm 330 1 The the DT cord-023095-4dannjjm 330 2 latter latter JJ cord-023095-4dannjjm 330 3 unexpected unexpected JJ cord-023095-4dannjjm 330 4 result result NN cord-023095-4dannjjm 330 5 prompted prompt VBD cord-023095-4dannjjm 330 6 measurement measurement NN cord-023095-4dannjjm 330 7 of of IN cord-023095-4dannjjm 330 8 fibrinogen fibrinogen JJ cord-023095-4dannjjm 330 9 concentrations concentration NNS cord-023095-4dannjjm 330 10 at at IN cord-023095-4dannjjm 330 11 day day NN cord-023095-4dannjjm 330 12 0 0 CD cord-023095-4dannjjm 330 13 and and CC cord-023095-4dannjjm 330 14 10 10 CD cord-023095-4dannjjm 330 15 in in IN cord-023095-4dannjjm 330 16 the the DT cord-023095-4dannjjm 330 17 last last JJ cord-023095-4dannjjm 330 18 5 5 CD cord-023095-4dannjjm 330 19 of of IN cord-023095-4dannjjm 330 20 these these DT cord-023095-4dannjjm 330 21 7 7 CD cord-023095-4dannjjm 330 22 cats cat NNS cord-023095-4dannjjm 330 23 . . . cord-023095-4dannjjm 331 1 Fibrinogen fibrinogen NN cord-023095-4dannjjm 331 2 was be VBD cord-023095-4dannjjm 331 3 not not RB cord-023095-4dannjjm 331 4 different different JJ cord-023095-4dannjjm 331 5 from from IN cord-023095-4dannjjm 331 6 day day NN cord-023095-4dannjjm 331 7 0 0 CD cord-023095-4dannjjm 331 8 to to IN cord-023095-4dannjjm 331 9 10 10 CD cord-023095-4dannjjm 331 10 in in IN cord-023095-4dannjjm 331 11 these these DT cord-023095-4dannjjm 331 12 5 5 CD cord-023095-4dannjjm 331 13 cats cat NNS cord-023095-4dannjjm 331 14 . . . cord-023095-4dannjjm 332 1 These these DT cord-023095-4dannjjm 332 2 results result NNS cord-023095-4dannjjm 332 3 suggest suggest VBP cord-023095-4dannjjm 332 4 that that IN cord-023095-4dannjjm 332 5 Platelet platelet NN cord-023095-4dannjjm 332 6 Mapping mapping NN cord-023095-4dannjjm 332 7 may may MD cord-023095-4dannjjm 332 8 be be VB cord-023095-4dannjjm 332 9 a a DT cord-023095-4dannjjm 332 10 simple simple JJ cord-023095-4dannjjm 332 11 , , , cord-023095-4dannjjm 332 12 outpatient outpatient JJ cord-023095-4dannjjm 332 13 clinical clinical JJ cord-023095-4dannjjm 332 14 tool tool NN cord-023095-4dannjjm 332 15 to to TO cord-023095-4dannjjm 332 16 measure measure VB cord-023095-4dannjjm 332 17 antiplatelet antiplatelet JJ cord-023095-4dannjjm 332 18 activity activity NN cord-023095-4dannjjm 332 19 in in IN cord-023095-4dannjjm 332 20 cats cat NNS cord-023095-4dannjjm 332 21 receiving receive VBG cord-023095-4dannjjm 332 22 clopidogrel clopidogrel NN cord-023095-4dannjjm 332 23 . . . cord-023095-4dannjjm 333 1 This this DT cord-023095-4dannjjm 333 2 clopidogrel clopidogrel NN cord-023095-4dannjjm 333 3 dose dose NN cord-023095-4dannjjm 333 4 resulted result VBD cord-023095-4dannjjm 333 5 in in IN cord-023095-4dannjjm 333 6 significant significant JJ cord-023095-4dannjjm 333 7 platelet platelet NN cord-023095-4dannjjm 333 8 inhibition inhibition NN cord-023095-4dannjjm 333 9 as as IN cord-023095-4dannjjm 333 10 measured measure VBN cord-023095-4dannjjm 333 11 by by IN cord-023095-4dannjjm 333 12 MA MA NNP cord-023095-4dannjjm 333 13 ADP ADP NNP cord-023095-4dannjjm 333 14 in in IN cord-023095-4dannjjm 333 15 all all DT cord-023095-4dannjjm 333 16 cats cat NNS cord-023095-4dannjjm 333 17 . . . cord-023095-4dannjjm 334 1 Further further JJ cord-023095-4dannjjm 334 2 studies study NNS cord-023095-4dannjjm 334 3 correlating correlate VBG cord-023095-4dannjjm 334 4 antiplatelet antiplatelet JJ cord-023095-4dannjjm 334 5 effects effect NNS cord-023095-4dannjjm 334 6 measured measure VBN cord-023095-4dannjjm 334 7 by by IN cord-023095-4dannjjm 334 8 Platelet platelet NN cord-023095-4dannjjm 334 9 Mapping mapping NN cord-023095-4dannjjm 334 10 with with IN cord-023095-4dannjjm 334 11 clinical clinical JJ cord-023095-4dannjjm 334 12 outcomes outcome NNS cord-023095-4dannjjm 334 13 in in IN cord-023095-4dannjjm 334 14 cats cat NNS cord-023095-4dannjjm 334 15 with with IN cord-023095-4dannjjm 334 16 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 334 17 are be VBP cord-023095-4dannjjm 334 18 warranted warrant VBN cord-023095-4dannjjm 334 19 . . . cord-023095-4dannjjm 335 1 This this DT cord-023095-4dannjjm 335 2 study study NN cord-023095-4dannjjm 335 3 investigated investigate VBD cord-023095-4dannjjm 335 4 the the DT cord-023095-4dannjjm 335 5 hemodynamic hemodynamic JJ cord-023095-4dannjjm 335 6 effects effect NNS cord-023095-4dannjjm 335 7 of of IN cord-023095-4dannjjm 335 8 application application NN cord-023095-4dannjjm 335 9 of of IN cord-023095-4dannjjm 335 10 an an DT cord-023095-4dannjjm 335 11 ITD itd NN cord-023095-4dannjjm 335 12 in in IN cord-023095-4dannjjm 335 13 a a DT cord-023095-4dannjjm 335 14 canine canine JJ cord-023095-4dannjjm 335 15 model model NN cord-023095-4dannjjm 335 16 of of IN cord-023095-4dannjjm 335 17 cardiopulmonary cardiopulmonary JJ cord-023095-4dannjjm 335 18 arrest arrest NN cord-023095-4dannjjm 335 19 . . . cord-023095-4dannjjm 336 1 8 8 CD cord-023095-4dannjjm 336 2 laboratory laboratory NN cord-023095-4dannjjm 336 3 beagles beagle NNS cord-023095-4dannjjm 336 4 which which WDT cord-023095-4dannjjm 336 5 were be VBD cord-023095-4dannjjm 336 6 part part NN cord-023095-4dannjjm 336 7 of of IN cord-023095-4dannjjm 336 8 a a DT cord-023095-4dannjjm 336 9 separate separate JJ cord-023095-4dannjjm 336 10 terminal terminal JJ cord-023095-4dannjjm 336 11 study study NN cord-023095-4dannjjm 336 12 were be VBD cord-023095-4dannjjm 336 13 anesthetized anesthetize VBN cord-023095-4dannjjm 336 14 and and CC cord-023095-4dannjjm 336 15 instrumented instrument VBN cord-023095-4dannjjm 336 16 for for IN cord-023095-4dannjjm 336 17 continuous continuous JJ cord-023095-4dannjjm 336 18 measurement measurement NN cord-023095-4dannjjm 336 19 and and CC cord-023095-4dannjjm 336 20 recording recording NN cord-023095-4dannjjm 336 21 of of IN cord-023095-4dannjjm 336 22 right right JJ cord-023095-4dannjjm 336 23 atrial atrial JJ cord-023095-4dannjjm 336 24 pressure pressure NN cord-023095-4dannjjm 336 25 , , , cord-023095-4dannjjm 336 26 arterial arterial JJ cord-023095-4dannjjm 336 27 pressure pressure NN cord-023095-4dannjjm 336 28 and and CC cord-023095-4dannjjm 336 29 carotid carotid JJ cord-023095-4dannjjm 336 30 blood blood NN cord-023095-4dannjjm 336 31 flow flow NN cord-023095-4dannjjm 336 32 . . . cord-023095-4dannjjm 337 1 Following follow VBG cord-023095-4dannjjm 337 2 euthanasia euthanasia NN cord-023095-4dannjjm 337 3 , , , cord-023095-4dannjjm 337 4 CPR CPR NNP cord-023095-4dannjjm 337 5 was be VBD cord-023095-4dannjjm 337 6 performed perform VBN cord-023095-4dannjjm 337 7 for for IN cord-023095-4dannjjm 337 8 one one CD cord-023095-4dannjjm 337 9 minute minute NN cord-023095-4dannjjm 337 10 , , , cord-023095-4dannjjm 337 11 then then RB cord-023095-4dannjjm 337 12 a a DT cord-023095-4dannjjm 337 13 pause pause NN cord-023095-4dannjjm 337 14 of of IN cord-023095-4dannjjm 337 15 one one CD cord-023095-4dannjjm 337 16 minute minute NN cord-023095-4dannjjm 337 17 followed follow VBN cord-023095-4dannjjm 337 18 by by IN cord-023095-4dannjjm 337 19 a a DT cord-023095-4dannjjm 337 20 second second JJ cord-023095-4dannjjm 337 21 one one CD cord-023095-4dannjjm 337 22 minute minute NN cord-023095-4dannjjm 337 23 period period NN cord-023095-4dannjjm 337 24 at at IN cord-023095-4dannjjm 337 25 a a DT cord-023095-4dannjjm 337 26 compression compression NN cord-023095-4dannjjm 337 27 rate rate NN cord-023095-4dannjjm 337 28 of of IN cord-023095-4dannjjm 337 29 100 100 CD cord-023095-4dannjjm 337 30 - - HYPH cord-023095-4dannjjm 337 31 120 120 CD cord-023095-4dannjjm 337 32 / / SYM cord-023095-4dannjjm 337 33 minute minute NN cord-023095-4dannjjm 337 34 , , , cord-023095-4dannjjm 337 35 ventilation ventilation NN cord-023095-4dannjjm 337 36 with with IN cord-023095-4dannjjm 337 37 100 100 CD cord-023095-4dannjjm 337 38 % % NN cord-023095-4dannjjm 337 39 oxygen oxygen NN cord-023095-4dannjjm 337 40 was be VBD cord-023095-4dannjjm 337 41 delivered deliver VBN cord-023095-4dannjjm 337 42 at at IN cord-023095-4dannjjm 337 43 eight eight CD cord-023095-4dannjjm 337 44 breaths breath NNS cord-023095-4dannjjm 337 45 / / SYM cord-023095-4dannjjm 337 46 min min NN cord-023095-4dannjjm 337 47 and and CC cord-023095-4dannjjm 337 48 15 15 CD cord-023095-4dannjjm 337 49 ml ml NNS cord-023095-4dannjjm 337 50 / / SYM cord-023095-4dannjjm 337 51 kg kg CC cord-023095-4dannjjm 337 52 tidal tidal JJ cord-023095-4dannjjm 337 53 volume volume NN cord-023095-4dannjjm 337 54 . . . cord-023095-4dannjjm 338 1 CPR CPR NNP cord-023095-4dannjjm 338 2 was be VBD cord-023095-4dannjjm 338 3 performed perform VBN cord-023095-4dannjjm 338 4 with with IN cord-023095-4dannjjm 338 5 the the DT cord-023095-4dannjjm 338 6 ITD ITD NNP cord-023095-4dannjjm 338 7 in in IN cord-023095-4dannjjm 338 8 place place NN cord-023095-4dannjjm 339 1 ( ( -LRB- cord-023095-4dannjjm 339 2 ITD ITD NNP cord-023095-4dannjjm 339 3 - - HYPH cord-023095-4dannjjm 339 4 CPR CPR NNP cord-023095-4dannjjm 339 5 ) ) -RRB- cord-023095-4dannjjm 340 1 and and CC cord-023095-4dannjjm 340 2 without without IN cord-023095-4dannjjm 340 3 the the DT cord-023095-4dannjjm 340 4 ITD ITD NNP cord-023095-4dannjjm 340 5 ( ( -LRB- cord-023095-4dannjjm 340 6 S S NNP cord-023095-4dannjjm 340 7 - - HYPH cord-023095-4dannjjm 340 8 CPR CPR NNP cord-023095-4dannjjm 340 9 ) ) -RRB- cord-023095-4dannjjm 340 10 for for IN cord-023095-4dannjjm 340 11 one one CD cord-023095-4dannjjm 340 12 period period NN cord-023095-4dannjjm 340 13 each each DT cord-023095-4dannjjm 340 14 in in IN cord-023095-4dannjjm 340 15 a a DT cord-023095-4dannjjm 340 16 randomized randomized JJ cord-023095-4dannjjm 340 17 fashion fashion NN cord-023095-4dannjjm 340 18 with with IN cord-023095-4dannjjm 340 19 the the DT cord-023095-4dannjjm 340 20 rescuer rescuer NN cord-023095-4dannjjm 340 21 blinded blind VBN cord-023095-4dannjjm 340 22 to to IN cord-023095-4dannjjm 340 23 its -PRON- PRP$ cord-023095-4dannjjm 340 24 application application NN cord-023095-4dannjjm 340 25 . . . cord-023095-4dannjjm 341 1 Baseline Baseline NNP cord-023095-4dannjjm 341 2 , , , cord-023095-4dannjjm 341 3 S S NNP cord-023095-4dannjjm 341 4 - - HYPH cord-023095-4dannjjm 341 5 CPR CPR NNP cord-023095-4dannjjm 341 6 and and CC cord-023095-4dannjjm 341 7 ITD ITD NNP cord-023095-4dannjjm 341 8 - - HYPH cord-023095-4dannjjm 341 9 CPR CPR NNP cord-023095-4dannjjm 341 10 data datum NNS cord-023095-4dannjjm 341 11 were be VBD cord-023095-4dannjjm 341 12 assessed assess VBN cord-023095-4dannjjm 341 13 for for IN cord-023095-4dannjjm 341 14 normality normality NN cord-023095-4dannjjm 341 15 , , , cord-023095-4dannjjm 341 16 a a DT cord-023095-4dannjjm 341 17 Kruskal Kruskal NNP cord-023095-4dannjjm 341 18 - - HYPH cord-023095-4dannjjm 341 19 Wallis Wallis NNP cord-023095-4dannjjm 341 20 one one CD cord-023095-4dannjjm 341 21 - - HYPH cord-023095-4dannjjm 341 22 way way NN cord-023095-4dannjjm 341 23 ANOVA anova NN cord-023095-4dannjjm 341 24 on on IN cord-023095-4dannjjm 341 25 ranks rank NNS cord-023095-4dannjjm 341 26 was be VBD cord-023095-4dannjjm 341 27 used use VBN cord-023095-4dannjjm 341 28 ( ( -LRB- cord-023095-4dannjjm 341 29 baseline baseline NN cord-023095-4dannjjm 341 30 v v IN cord-023095-4dannjjm 341 31 CPR CPR NNP cord-023095-4dannjjm 341 32 ) ) -RRB- cord-023095-4dannjjm 341 33 . . . cord-023095-4dannjjm 342 1 When when WRB cord-023095-4dannjjm 342 2 appropriate appropriate VB cord-023095-4dannjjm 342 3 a a DT cord-023095-4dannjjm 342 4 pairwise pairwise JJ cord-023095-4dannjjm 342 5 multiple multiple JJ cord-023095-4dannjjm 342 6 comparison comparison NN cord-023095-4dannjjm 342 7 procedure procedure NN cord-023095-4dannjjm 342 8 ( ( -LRB- cord-023095-4dannjjm 342 9 Dunn Dunn NNP cord-023095-4dannjjm 342 10 's 's POS cord-023095-4dannjjm 342 11 method method NN cord-023095-4dannjjm 342 12 ) ) -RRB- cord-023095-4dannjjm 342 13 was be VBD cord-023095-4dannjjm 342 14 used use VBN cord-023095-4dannjjm 342 15 . . . cord-023095-4dannjjm 343 1 Percentage percentage NN cord-023095-4dannjjm 343 2 of of IN cord-023095-4dannjjm 343 3 baseline baseline JJ cord-023095-4dannjjm 343 4 S S NNP cord-023095-4dannjjm 343 5 - - HYPH cord-023095-4dannjjm 343 6 CPR CPR NNP cord-023095-4dannjjm 344 1 v v LS cord-023095-4dannjjm 345 1 ITD ITD NNP cord-023095-4dannjjm 345 2 - - HYPH cord-023095-4dannjjm 345 3 CPR CPR NNP cord-023095-4dannjjm 345 4 was be VBD cord-023095-4dannjjm 345 5 assessed assess VBN cord-023095-4dannjjm 345 6 using use VBG cord-023095-4dannjjm 345 7 the the DT cord-023095-4dannjjm 345 8 Student Student NNP cord-023095-4dannjjm 345 9 t t NN cord-023095-4dannjjm 345 10 - - HYPH cord-023095-4dannjjm 345 11 test test NN cord-023095-4dannjjm 345 12 . . . cord-023095-4dannjjm 346 1 The the DT cord-023095-4dannjjm 346 2 right right JJ cord-023095-4dannjjm 346 3 atrial atrial JJ cord-023095-4dannjjm 346 4 diastolic diastolic JJ cord-023095-4dannjjm 346 5 pressure pressure NN cord-023095-4dannjjm 346 6 was be VBD cord-023095-4dannjjm 346 7 significantly significantly RB cord-023095-4dannjjm 346 8 more more RBR cord-023095-4dannjjm 346 9 negative negative JJ cord-023095-4dannjjm 346 10 with with IN cord-023095-4dannjjm 346 11 the the DT cord-023095-4dannjjm 346 12 ITD ITD NNP cord-023095-4dannjjm 346 13 attached attach VBN cord-023095-4dannjjm 346 14 than than IN cord-023095-4dannjjm 346 15 without without IN cord-023095-4dannjjm 346 16 ( ( -LRB- cord-023095-4dannjjm 346 17 p p NN cord-023095-4dannjjm 346 18 5 5 CD cord-023095-4dannjjm 346 19 0.02 0.02 CD cord-023095-4dannjjm 346 20 ) ) -RRB- cord-023095-4dannjjm 346 21 , , , cord-023095-4dannjjm 346 22 the the DT cord-023095-4dannjjm 346 23 coronary coronary JJ cord-023095-4dannjjm 346 24 perfusion perfusion NN cord-023095-4dannjjm 346 25 pressure pressure NN cord-023095-4dannjjm 346 26 and and CC cord-023095-4dannjjm 346 27 carotid carotid JJ cord-023095-4dannjjm 346 28 blood blood NN cord-023095-4dannjjm 346 29 flow flow NN cord-023095-4dannjjm 346 30 were be VBD cord-023095-4dannjjm 346 31 significantly significantly RB cord-023095-4dannjjm 346 32 higher high JJR cord-023095-4dannjjm 346 33 during during IN cord-023095-4dannjjm 346 34 CPR CPR NNP cord-023095-4dannjjm 346 35 with with IN cord-023095-4dannjjm 346 36 the the DT cord-023095-4dannjjm 346 37 ITD ITD NNP cord-023095-4dannjjm 346 38 than than IN cord-023095-4dannjjm 346 39 standard standard JJ cord-023095-4dannjjm 346 40 CPR CPR NNP cord-023095-4dannjjm 346 41 ( ( -LRB- cord-023095-4dannjjm 346 42 p p NN cord-023095-4dannjjm 346 43 5 5 CD cord-023095-4dannjjm 346 44 0.015 0.015 CD cord-023095-4dannjjm 346 45 , , , cord-023095-4dannjjm 346 46 p p NN cord-023095-4dannjjm 346 47 5 5 CD cord-023095-4dannjjm 346 48 0.017 0.017 CD cord-023095-4dannjjm 346 49 ) ) -RRB- cord-023095-4dannjjm 346 50 . . . cord-023095-4dannjjm 347 1 No no DT cord-023095-4dannjjm 347 2 significant significant JJ cord-023095-4dannjjm 347 3 differences difference NNS cord-023095-4dannjjm 347 4 in in IN cord-023095-4dannjjm 347 5 diastolic diastolic JJ cord-023095-4dannjjm 347 6 , , , cord-023095-4dannjjm 347 7 mean mean JJ cord-023095-4dannjjm 347 8 or or CC cord-023095-4dannjjm 347 9 systolic systolic JJ cord-023095-4dannjjm 347 10 arterial arterial JJ cord-023095-4dannjjm 347 11 pressure pressure NN cord-023095-4dannjjm 347 12 or or CC cord-023095-4dannjjm 347 13 end end VB cord-023095-4dannjjm 347 14 tidal tidal JJ cord-023095-4dannjjm 347 15 CO co NN cord-023095-4dannjjm 347 16 2 2 CD cord-023095-4dannjjm 347 17 were be VBD cord-023095-4dannjjm 347 18 seen see VBN cord-023095-4dannjjm 347 19 . . . cord-023095-4dannjjm 348 1 Application application NN cord-023095-4dannjjm 348 2 of of IN cord-023095-4dannjjm 348 3 the the DT cord-023095-4dannjjm 348 4 ITD ITD NNP cord-023095-4dannjjm 348 5 resulted result VBD cord-023095-4dannjjm 348 6 in in IN cord-023095-4dannjjm 348 7 significantly significantly RB cord-023095-4dannjjm 348 8 improved improve VBN cord-023095-4dannjjm 348 9 hemodynamics hemodynamic NNS cord-023095-4dannjjm 348 10 during during IN cord-023095-4dannjjm 348 11 CPR CPR NNP cord-023095-4dannjjm 348 12 in in IN cord-023095-4dannjjm 348 13 dogs dog NNS cord-023095-4dannjjm 348 14 . . . cord-023095-4dannjjm 349 1 Clinical clinical JJ cord-023095-4dannjjm 349 2 evaluation evaluation NN cord-023095-4dannjjm 349 3 of of IN cord-023095-4dannjjm 349 4 the the DT cord-023095-4dannjjm 349 5 device device NN cord-023095-4dannjjm 349 6 is be VBZ cord-023095-4dannjjm 349 7 warranted warrant VBN cord-023095-4dannjjm 349 8 to to TO cord-023095-4dannjjm 349 9 examine examine VB cord-023095-4dannjjm 349 10 whether whether IN cord-023095-4dannjjm 349 11 this this DT cord-023095-4dannjjm 349 12 translates translate VBZ cord-023095-4dannjjm 349 13 into into IN cord-023095-4dannjjm 349 14 improved improved JJ cord-023095-4dannjjm 349 15 success success NN cord-023095-4dannjjm 349 16 in in IN cord-023095-4dannjjm 349 17 resuscitation resuscitation NN cord-023095-4dannjjm 349 18 and and CC cord-023095-4dannjjm 349 19 survival survival NN cord-023095-4dannjjm 349 20 . . . cord-023095-4dannjjm 350 1 Left leave VBN cord-023095-4dannjjm 350 2 ventricular ventricular JJ cord-023095-4dannjjm 350 3 ( ( -LRB- cord-023095-4dannjjm 350 4 LV LV NNP cord-023095-4dannjjm 350 5 ) ) -RRB- cord-023095-4dannjjm 350 6 systolic systolic JJ cord-023095-4dannjjm 350 7 dysfunction dysfunction NN cord-023095-4dannjjm 350 8 is be VBZ cord-023095-4dannjjm 350 9 a a DT cord-023095-4dannjjm 350 10 common common JJ cord-023095-4dannjjm 350 11 problem problem NN cord-023095-4dannjjm 350 12 in in IN cord-023095-4dannjjm 350 13 dogs dog NNS cord-023095-4dannjjm 350 14 and and CC cord-023095-4dannjjm 350 15 can can MD cord-023095-4dannjjm 350 16 be be VB cord-023095-4dannjjm 350 17 due due JJ cord-023095-4dannjjm 350 18 to to IN cord-023095-4dannjjm 350 19 a a DT cord-023095-4dannjjm 350 20 variety variety NN cord-023095-4dannjjm 350 21 of of IN cord-023095-4dannjjm 350 22 etiologies etiology NNS cord-023095-4dannjjm 350 23 . . . cord-023095-4dannjjm 351 1 One one CD cord-023095-4dannjjm 351 2 potential potential JJ cord-023095-4dannjjm 351 3 etiology etiology NN cord-023095-4dannjjm 351 4 for for IN cord-023095-4dannjjm 351 5 systolic systolic JJ cord-023095-4dannjjm 351 6 dysfunction dysfunction NN cord-023095-4dannjjm 351 7 is be VBZ cord-023095-4dannjjm 351 8 persistent persistent JJ cord-023095-4dannjjm 351 9 or or CC cord-023095-4dannjjm 351 10 paroxysmal paroxysmal JJ cord-023095-4dannjjm 351 11 tachyarrhythmias tachyarrhythmia NNS cord-023095-4dannjjm 351 12 , , , cord-023095-4dannjjm 351 13 leading lead VBG cord-023095-4dannjjm 351 14 to to IN cord-023095-4dannjjm 351 15 tachycardia tachycardia NN cord-023095-4dannjjm 351 16 - - HYPH cord-023095-4dannjjm 351 17 induced induce VBN cord-023095-4dannjjm 351 18 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 351 19 ( ( -LRB- cord-023095-4dannjjm 351 20 TICM TICM NNP cord-023095-4dannjjm 351 21 ) ) -RRB- cord-023095-4dannjjm 351 22 . . . cord-023095-4dannjjm 352 1 In in IN cord-023095-4dannjjm 352 2 humans human NNS cord-023095-4dannjjm 352 3 , , , cord-023095-4dannjjm 352 4 TICM TICM NNP cord-023095-4dannjjm 352 5 carries carry VBZ cord-023095-4dannjjm 352 6 a a DT cord-023095-4dannjjm 352 7 relatively relatively RB cord-023095-4dannjjm 352 8 good good JJ cord-023095-4dannjjm 352 9 prognosis prognosis NN cord-023095-4dannjjm 352 10 in in IN cord-023095-4dannjjm 352 11 that that DT cord-023095-4dannjjm 352 12 remodeling remodeling NN cord-023095-4dannjjm 352 13 may may MD cord-023095-4dannjjm 352 14 be be VB cord-023095-4dannjjm 352 15 reversible reversible JJ cord-023095-4dannjjm 352 16 with with IN cord-023095-4dannjjm 352 17 normalization normalization NN cord-023095-4dannjjm 352 18 of of IN cord-023095-4dannjjm 352 19 heart heart NN cord-023095-4dannjjm 352 20 rate rate NN cord-023095-4dannjjm 352 21 . . . cord-023095-4dannjjm 353 1 Differentiating differentiate VBG cord-023095-4dannjjm 353 2 between between IN cord-023095-4dannjjm 353 3 primary primary JJ cord-023095-4dannjjm 353 4 and and CC cord-023095-4dannjjm 353 5 secondary secondary JJ cord-023095-4dannjjm 353 6 tachyarrhythmias tachyarrhythmia NNS cord-023095-4dannjjm 353 7 in in IN cord-023095-4dannjjm 353 8 dogs dog NNS cord-023095-4dannjjm 353 9 with with IN cord-023095-4dannjjm 353 10 systolic systolic JJ cord-023095-4dannjjm 353 11 dysfunction dysfunction NN cord-023095-4dannjjm 353 12 is be VBZ cord-023095-4dannjjm 353 13 critical critical JJ cord-023095-4dannjjm 353 14 for for IN cord-023095-4dannjjm 353 15 prognostic prognostic JJ cord-023095-4dannjjm 353 16 purposes purpose NNS cord-023095-4dannjjm 353 17 as as IN cord-023095-4dannjjm 353 18 primary primary JJ cord-023095-4dannjjm 353 19 tachyarrhythmias tachyarrhythmia NNS cord-023095-4dannjjm 353 20 may may MD cord-023095-4dannjjm 353 21 be be VB cord-023095-4dannjjm 353 22 associated associate VBN cord-023095-4dannjjm 353 23 with with IN cord-023095-4dannjjm 353 24 a a DT cord-023095-4dannjjm 353 25 better well JJR cord-023095-4dannjjm 353 26 outcome outcome NN cord-023095-4dannjjm 353 27 . . . cord-023095-4dannjjm 354 1 The the DT cord-023095-4dannjjm 354 2 goal goal NN cord-023095-4dannjjm 354 3 of of IN cord-023095-4dannjjm 354 4 our -PRON- PRP$ cord-023095-4dannjjm 354 5 study study NN cord-023095-4dannjjm 354 6 was be VBD cord-023095-4dannjjm 354 7 to to TO cord-023095-4dannjjm 354 8 describe describe VB cord-023095-4dannjjm 354 9 a a DT cord-023095-4dannjjm 354 10 population population NN cord-023095-4dannjjm 354 11 of of IN cord-023095-4dannjjm 354 12 dogs dog NNS cord-023095-4dannjjm 354 13 with with IN cord-023095-4dannjjm 354 14 TICM TICM NNP cord-023095-4dannjjm 354 15 and and CC cord-023095-4dannjjm 354 16 to to TO cord-023095-4dannjjm 354 17 determine determine VB cord-023095-4dannjjm 354 18 if if IN cord-023095-4dannjjm 354 19 treatment treatment NN cord-023095-4dannjjm 354 20 of of IN cord-023095-4dannjjm 354 21 arrhythmias arrhythmia NNS cord-023095-4dannjjm 354 22 was be VBD cord-023095-4dannjjm 354 23 associated associate VBN cord-023095-4dannjjm 354 24 with with IN cord-023095-4dannjjm 354 25 reversible reversible JJ cord-023095-4dannjjm 354 26 cardiac cardiac JJ cord-023095-4dannjjm 354 27 remodeling remodeling NN cord-023095-4dannjjm 354 28 as as IN cord-023095-4dannjjm 354 29 indicated indicate VBN cord-023095-4dannjjm 354 30 by by IN cord-023095-4dannjjm 354 31 standard standard JJ cord-023095-4dannjjm 354 32 echocardiographic echocardiographic JJ cord-023095-4dannjjm 354 33 parameters parameter NNS cord-023095-4dannjjm 354 34 . . . cord-023095-4dannjjm 355 1 Medical medical JJ cord-023095-4dannjjm 355 2 records record NNS cord-023095-4dannjjm 355 3 of of IN cord-023095-4dannjjm 355 4 dogs dog NNS cord-023095-4dannjjm 355 5 referred refer VBN cord-023095-4dannjjm 355 6 to to IN cord-023095-4dannjjm 355 7 the the DT cord-023095-4dannjjm 355 8 cardiology cardiology NN cord-023095-4dannjjm 355 9 service service NN cord-023095-4dannjjm 355 10 of of IN cord-023095-4dannjjm 355 11 KSU KSU NNP cord-023095-4dannjjm 355 12 VMTH VMTH NNP cord-023095-4dannjjm 355 13 from from IN cord-023095-4dannjjm 355 14 2008 2008 CD cord-023095-4dannjjm 355 15 to to IN cord-023095-4dannjjm 355 16 2010 2010 CD cord-023095-4dannjjm 355 17 were be VBD cord-023095-4dannjjm 355 18 reviewed review VBN cord-023095-4dannjjm 355 19 . . . cord-023095-4dannjjm 356 1 TICM TICM NNP cord-023095-4dannjjm 356 2 was be VBD cord-023095-4dannjjm 356 3 defined define VBN cord-023095-4dannjjm 356 4 as as IN cord-023095-4dannjjm 356 5 the the DT cord-023095-4dannjjm 356 6 presence presence NN cord-023095-4dannjjm 356 7 of of IN cord-023095-4dannjjm 356 8 severe severe JJ cord-023095-4dannjjm 356 9 tachyarrhythmias tachyarrhythmia NNS cord-023095-4dannjjm 356 10 that that WDT cord-023095-4dannjjm 356 11 were be VBD cord-023095-4dannjjm 356 12 reversible reversible JJ cord-023095-4dannjjm 356 13 with with IN cord-023095-4dannjjm 356 14 treatment treatment NN cord-023095-4dannjjm 356 15 , , , cord-023095-4dannjjm 356 16 systolic systolic JJ cord-023095-4dannjjm 356 17 dysfunction dysfunction NN cord-023095-4dannjjm 356 18 or or CC cord-023095-4dannjjm 356 19 ventricular ventricular JJ cord-023095-4dannjjm 356 20 enlargement enlargement NN cord-023095-4dannjjm 356 21 that that WDT cord-023095-4dannjjm 356 22 improved improve VBD cord-023095-4dannjjm 356 23 with with IN cord-023095-4dannjjm 356 24 treatment treatment NN cord-023095-4dannjjm 356 25 of of IN cord-023095-4dannjjm 356 26 the the DT cord-023095-4dannjjm 356 27 arrhythmia arrhythmia NN cord-023095-4dannjjm 356 28 , , , cord-023095-4dannjjm 356 29 or or CC cord-023095-4dannjjm 356 30 dogs dog NNS cord-023095-4dannjjm 356 31 with with IN cord-023095-4dannjjm 356 32 severe severe JJ cord-023095-4dannjjm 356 33 tachyarrhythmias tachyarrhythmia NNS cord-023095-4dannjjm 356 34 and and CC cord-023095-4dannjjm 356 35 systolic systolic JJ cord-023095-4dannjjm 356 36 dysfunction dysfunction NN cord-023095-4dannjjm 356 37 of of IN cord-023095-4dannjjm 356 38 breeds breed NNS cord-023095-4dannjjm 356 39 with with IN cord-023095-4dannjjm 356 40 that that DT cord-023095-4dannjjm 356 41 are be VBP cord-023095-4dannjjm 356 42 atypical atypical JJ cord-023095-4dannjjm 356 43 for for IN cord-023095-4dannjjm 356 44 idiopathic idiopathic JJ cord-023095-4dannjjm 356 45 dilated dilated JJ cord-023095-4dannjjm 356 46 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 356 47 . . . cord-023095-4dannjjm 357 1 Exclusion exclusion NN cord-023095-4dannjjm 357 2 criteria criterion NNS cord-023095-4dannjjm 357 3 were be VBD cord-023095-4dannjjm 357 4 dogs dog NNS cord-023095-4dannjjm 357 5 with with IN cord-023095-4dannjjm 357 6 congenital congenital JJ cord-023095-4dannjjm 357 7 heart heart NN cord-023095-4dannjjm 357 8 disease disease NN cord-023095-4dannjjm 357 9 , , , cord-023095-4dannjjm 357 10 severe severe JJ cord-023095-4dannjjm 357 11 mitral mitral JJ cord-023095-4dannjjm 357 12 regurgitation regurgitation NN cord-023095-4dannjjm 357 13 , , , cord-023095-4dannjjm 357 14 and and CC cord-023095-4dannjjm 357 15 endocarditis endocarditis NN cord-023095-4dannjjm 357 16 . . . cord-023095-4dannjjm 358 1 Transthoracic Transthoracic NNP cord-023095-4dannjjm 358 2 echocardiography echocardiography NN cord-023095-4dannjjm 358 3 , , , cord-023095-4dannjjm 358 4 thoracic thoracic JJ cord-023095-4dannjjm 358 5 radiographs radiograph NNS cord-023095-4dannjjm 358 6 and and CC cord-023095-4dannjjm 358 7 electrocardiography electrocardiography NN cord-023095-4dannjjm 358 8 ( ( -LRB- cord-023095-4dannjjm 358 9 ECG ECG NNP cord-023095-4dannjjm 358 10 ) ) -RRB- cord-023095-4dannjjm 358 11 were be VBD cord-023095-4dannjjm 358 12 performed perform VBN cord-023095-4dannjjm 358 13 in in IN cord-023095-4dannjjm 358 14 all all DT cord-023095-4dannjjm 358 15 dogs dog NNS cord-023095-4dannjjm 358 16 . . . cord-023095-4dannjjm 359 1 Ventricular ventricular JJ cord-023095-4dannjjm 359 2 enlargement enlargement NN cord-023095-4dannjjm 359 3 and and CC cord-023095-4dannjjm 359 4 systolic systolic JJ cord-023095-4dannjjm 359 5 dysfunction dysfunction NN cord-023095-4dannjjm 359 6 were be VBD cord-023095-4dannjjm 359 7 defined define VBN cord-023095-4dannjjm 359 8 according accord VBG cord-023095-4dannjjm 359 9 to to IN cord-023095-4dannjjm 359 10 standard standard JJ cord-023095-4dannjjm 359 11 echocardiographic echocardiographic JJ cord-023095-4dannjjm 359 12 parameters parameter NNS cord-023095-4dannjjm 359 13 . . . cord-023095-4dannjjm 360 1 Arrhythmias arrhythmia NNS cord-023095-4dannjjm 360 2 were be VBD cord-023095-4dannjjm 360 3 confirmed confirm VBN cord-023095-4dannjjm 360 4 with with IN cord-023095-4dannjjm 360 5 a a DT cord-023095-4dannjjm 360 6 Holter Holter NNP cord-023095-4dannjjm 360 7 monitor monitor NN cord-023095-4dannjjm 360 8 in in IN cord-023095-4dannjjm 360 9 7 7 CD cord-023095-4dannjjm 360 10 dogs dog NNS cord-023095-4dannjjm 360 11 . . . cord-023095-4dannjjm 361 1 A a DT cord-023095-4dannjjm 361 2 total total NN cord-023095-4dannjjm 361 3 of of IN cord-023095-4dannjjm 361 4 12 12 CD cord-023095-4dannjjm 361 5 dogs dog NNS cord-023095-4dannjjm 361 6 were be VBD cord-023095-4dannjjm 361 7 included include VBN cord-023095-4dannjjm 361 8 in in IN cord-023095-4dannjjm 361 9 the the DT cord-023095-4dannjjm 361 10 study study NN cord-023095-4dannjjm 361 11 . . . cord-023095-4dannjjm 362 1 Mean mean JJ cord-023095-4dannjjm 362 2 age age NN cord-023095-4dannjjm 362 3 was be VBD cord-023095-4dannjjm 362 4 7 7 CD cord-023095-4dannjjm 362 5 years year NNS cord-023095-4dannjjm 363 1 ( ( -LRB- cord-023095-4dannjjm 363 2 range range NNP cord-023095-4dannjjm 363 3 2 2 CD cord-023095-4dannjjm 363 4 - - SYM cord-023095-4dannjjm 363 5 12 12 CD cord-023095-4dannjjm 363 6 years year NNS cord-023095-4dannjjm 363 7 ) ) -RRB- cord-023095-4dannjjm 363 8 with with IN cord-023095-4dannjjm 363 9 8 8 CD cord-023095-4dannjjm 363 10 males male NNS cord-023095-4dannjjm 363 11 ( ( -LRB- cord-023095-4dannjjm 363 12 4 4 CD cord-023095-4dannjjm 363 13 intact intact JJ cord-023095-4dannjjm 363 14 , , , cord-023095-4dannjjm 363 15 4 4 CD cord-023095-4dannjjm 363 16 castrated castrate VBN cord-023095-4dannjjm 363 17 ) ) -RRB- cord-023095-4dannjjm 363 18 and and CC cord-023095-4dannjjm 363 19 4 4 CD cord-023095-4dannjjm 363 20 females female NNS cord-023095-4dannjjm 363 21 ( ( -LRB- cord-023095-4dannjjm 363 22 3 3 CD cord-023095-4dannjjm 363 23 spayed spay VBN cord-023095-4dannjjm 363 24 , , , cord-023095-4dannjjm 363 25 1 1 CD cord-023095-4dannjjm 363 26 intact intact JJ cord-023095-4dannjjm 363 27 ) ) -RRB- cord-023095-4dannjjm 363 28 . . . cord-023095-4dannjjm 364 1 Four four CD cord-023095-4dannjjm 364 2 dogs dog NNS cord-023095-4dannjjm 364 3 had have VBD cord-023095-4dannjjm 364 4 pulmonary pulmonary JJ cord-023095-4dannjjm 364 5 venous venous JJ cord-023095-4dannjjm 364 6 congestion congestion NN cord-023095-4dannjjm 364 7 or or CC cord-023095-4dannjjm 364 8 pulmonary pulmonary JJ cord-023095-4dannjjm 364 9 edema edema NN cord-023095-4dannjjm 364 10 and and CC cord-023095-4dannjjm 364 11 two two CD cord-023095-4dannjjm 364 12 dogs dog NNS cord-023095-4dannjjm 364 13 had have VBD cord-023095-4dannjjm 364 14 ascites ascite NNS cord-023095-4dannjjm 364 15 . . . cord-023095-4dannjjm 365 1 At at IN cord-023095-4dannjjm 365 2 initial initial JJ cord-023095-4dannjjm 365 3 presentation presentation NN cord-023095-4dannjjm 365 4 , , , cord-023095-4dannjjm 365 5 the the DT cord-023095-4dannjjm 365 6 meanAESD meanaesd FW cord-023095-4dannjjm 365 7 values value NNS cord-023095-4dannjjm 365 8 were be VBD cord-023095-4dannjjm 365 9 as as IN cord-023095-4dannjjm 365 10 follows follow VBZ cord-023095-4dannjjm 365 11 : : : cord-023095-4dannjjm 365 12 heart heart NN cord-023095-4dannjjm 365 13 rate rate NN cord-023095-4dannjjm 365 14 219AE75 219AE75 NNP cord-023095-4dannjjm 365 15 bpm bpm NNP cord-023095-4dannjjm 365 16 , , , cord-023095-4dannjjm 365 17 M M NNP cord-023095-4dannjjm 365 18 - - HYPH cord-023095-4dannjjm 365 19 mode mode NN cord-023095-4dannjjm 365 20 fractional fractional JJ cord-023095-4dannjjm 365 21 shortening shortening NN cord-023095-4dannjjm 365 22 ( ( -LRB- cord-023095-4dannjjm 365 23 FS FS NNP cord-023095-4dannjjm 365 24 ) ) -RRB- cord-023095-4dannjjm 365 25 17.29AE9.05 17.29ae9.05 CD cord-023095-4dannjjm 365 26 % % NN cord-023095-4dannjjm 365 27 , , , cord-023095-4dannjjm 365 28 ejection ejection NN cord-023095-4dannjjm 365 29 fraction fraction NN cord-023095-4dannjjm 365 30 ( ( -LRB- cord-023095-4dannjjm 365 31 EF EF NNP cord-023095-4dannjjm 365 32 ) ) -RRB- cord-023095-4dannjjm 365 33 using use VBG cord-023095-4dannjjm 365 34 the the DT cord-023095-4dannjjm 365 35 area area NN cord-023095-4dannjjm 365 36 - - HYPH cord-023095-4dannjjm 365 37 length length NN cord-023095-4dannjjm 365 38 method method NN cord-023095-4dannjjm 365 39 30.69AE13.45 30.69ae13.45 CD cord-023095-4dannjjm 365 40 % % NN cord-023095-4dannjjm 365 41 , , , cord-023095-4dannjjm 365 42 and and CC cord-023095-4dannjjm 365 43 left leave VBN cord-023095-4dannjjm 365 44 atrial atrial JJ cord-023095-4dannjjm 365 45 to to IN cord-023095-4dannjjm 365 46 aortic aortic JJ cord-023095-4dannjjm 365 47 root root NN cord-023095-4dannjjm 365 48 ratio ratio NN cord-023095-4dannjjm 365 49 ( ( -LRB- cord-023095-4dannjjm 365 50 LA LA NNP cord-023095-4dannjjm 365 51 / / SYM cord-023095-4dannjjm 365 52 Ao Ao NNP cord-023095-4dannjjm 365 53 ) ) -RRB- cord-023095-4dannjjm 365 54 1.92AE0.37 1.92ae0.37 CD cord-023095-4dannjjm 365 55 . . . cord-023095-4dannjjm 366 1 Initial initial JJ cord-023095-4dannjjm 366 2 meanAESD meanaesd NN cord-023095-4dannjjm 366 3 M M NNP cord-023095-4dannjjm 366 4 - - HYPH cord-023095-4dannjjm 366 5 mode mode NN cord-023095-4dannjjm 366 6 derived derive VBN cord-023095-4dannjjm 366 7 LV LV NNP cord-023095-4dannjjm 366 8 internal internal JJ cord-023095-4dannjjm 366 9 dimensions dimension NNS cord-023095-4dannjjm 366 10 corrected correct VBN cord-023095-4dannjjm 366 11 for for IN cord-023095-4dannjjm 366 12 body body NN cord-023095-4dannjjm 366 13 weight weight NN cord-023095-4dannjjm 366 14 were be VBD cord-023095-4dannjjm 366 15 as as IN cord-023095-4dannjjm 366 16 follows follow VBZ cord-023095-4dannjjm 366 17 : : : cord-023095-4dannjjm 366 18 diastolic diastolic JJ cord-023095-4dannjjm 366 19 1.92AE0.37 1.92ae0.37 CD cord-023095-4dannjjm 366 20 and and CC cord-023095-4dannjjm 366 21 systolic systolic JJ cord-023095-4dannjjm 366 22 1.49AE0.38 1.49ae0.38 CD cord-023095-4dannjjm 366 23 . . . cord-023095-4dannjjm 367 1 At at RB cord-023095-4dannjjm 367 2 least least RBS cord-023095-4dannjjm 367 3 one one CD cord-023095-4dannjjm 367 4 of of IN cord-023095-4dannjjm 367 5 the the DT cord-023095-4dannjjm 367 6 following following JJ cord-023095-4dannjjm 367 7 tachyarrhythmias tachyarrhythmia NNS cord-023095-4dannjjm 367 8 were be VBD cord-023095-4dannjjm 367 9 identified identify VBN cord-023095-4dannjjm 367 10 in in IN cord-023095-4dannjjm 367 11 each each DT cord-023095-4dannjjm 367 12 dog dog NN cord-023095-4dannjjm 367 13 : : : cord-023095-4dannjjm 367 14 atrial atrial JJ cord-023095-4dannjjm 367 15 fibrillation fibrillation NN cord-023095-4dannjjm 367 16 ( ( -LRB- cord-023095-4dannjjm 367 17 4 4 CD cord-023095-4dannjjm 367 18 ) ) -RRB- cord-023095-4dannjjm 367 19 , , , cord-023095-4dannjjm 367 20 supraventricular supraventricular JJ cord-023095-4dannjjm 367 21 tachycardia tachycardia NN cord-023095-4dannjjm 367 22 ( ( -LRB- cord-023095-4dannjjm 367 23 5 5 CD cord-023095-4dannjjm 367 24 ) ) -RRB- cord-023095-4dannjjm 367 25 , , , cord-023095-4dannjjm 367 26 junctional junctional JJ cord-023095-4dannjjm 367 27 tachycardia tachycardia NN cord-023095-4dannjjm 367 28 ( ( -LRB- cord-023095-4dannjjm 367 29 2 2 CD cord-023095-4dannjjm 367 30 ) ) -RRB- cord-023095-4dannjjm 367 31 , , , cord-023095-4dannjjm 367 32 and and CC cord-023095-4dannjjm 367 33 ventricular ventricular JJ cord-023095-4dannjjm 367 34 arrhythmias arrhythmia NNS cord-023095-4dannjjm 367 35 ( ( -LRB- cord-023095-4dannjjm 367 36 3 3 CD cord-023095-4dannjjm 367 37 ) ) -RRB- cord-023095-4dannjjm 367 38 . . . cord-023095-4dannjjm 368 1 Ten ten CD cord-023095-4dannjjm 368 2 dogs dog NNS cord-023095-4dannjjm 368 3 were be VBD cord-023095-4dannjjm 368 4 available available JJ cord-023095-4dannjjm 368 5 for for IN cord-023095-4dannjjm 368 6 follow follow NN cord-023095-4dannjjm 368 7 up up RP cord-023095-4dannjjm 368 8 . . . cord-023095-4dannjjm 369 1 Seven seven CD cord-023095-4dannjjm 369 2 dogs dog NNS cord-023095-4dannjjm 369 3 improved improve VBD cord-023095-4dannjjm 369 4 in in IN cord-023095-4dannjjm 369 5 at at RB cord-023095-4dannjjm 369 6 least least RBS cord-023095-4dannjjm 369 7 one one CD cord-023095-4dannjjm 369 8 of of IN cord-023095-4dannjjm 369 9 the the DT cord-023095-4dannjjm 369 10 following follow VBG cord-023095-4dannjjm 369 11 parameters parameter NNS cord-023095-4dannjjm 369 12 : : : cord-023095-4dannjjm 369 13 resolution resolution NN cord-023095-4dannjjm 369 14 of of IN cord-023095-4dannjjm 369 15 tachyarrhythmia tachyarrhythmia NN cord-023095-4dannjjm 369 16 ( ( -LRB- cord-023095-4dannjjm 369 17 3 3 CD cord-023095-4dannjjm 369 18 ) ) -RRB- cord-023095-4dannjjm 369 19 , , , cord-023095-4dannjjm 369 20 improved improve VBN cord-023095-4dannjjm 369 21 systolic systolic JJ cord-023095-4dannjjm 369 22 function function NN cord-023095-4dannjjm 369 23 ( ( -LRB- cord-023095-4dannjjm 369 24 3 3 CD cord-023095-4dannjjm 369 25 ) ) -RRB- cord-023095-4dannjjm 370 1 Antidiuretic antidiuretic JJ cord-023095-4dannjjm 370 2 hormone hormone NN cord-023095-4dannjjm 370 3 ( ( -LRB- cord-023095-4dannjjm 370 4 ADH ADH NNP cord-023095-4dannjjm 370 5 ) ) -RRB- cord-023095-4dannjjm 370 6 has have VBZ cord-023095-4dannjjm 370 7 been be VBN cord-023095-4dannjjm 370 8 shown show VBN cord-023095-4dannjjm 370 9 to to TO cord-023095-4dannjjm 370 10 be be VB cord-023095-4dannjjm 370 11 elevated elevate VBN cord-023095-4dannjjm 370 12 in in IN cord-023095-4dannjjm 370 13 humans human NNS cord-023095-4dannjjm 370 14 with with IN cord-023095-4dannjjm 370 15 congestive congestive JJ cord-023095-4dannjjm 370 16 heart heart NN cord-023095-4dannjjm 370 17 failure failure NN cord-023095-4dannjjm 370 18 ( ( -LRB- cord-023095-4dannjjm 370 19 CHF CHF NNP cord-023095-4dannjjm 370 20 ) ) -RRB- cord-023095-4dannjjm 370 21 . . . cord-023095-4dannjjm 371 1 Recently recently RB cord-023095-4dannjjm 371 2 , , , cord-023095-4dannjjm 371 3 antidiuretic antidiuretic JJ cord-023095-4dannjjm 371 4 hormone hormone NN cord-023095-4dannjjm 371 5 antagonists antagonist NNS cord-023095-4dannjjm 371 6 were be VBD cord-023095-4dannjjm 371 7 successful successful JJ cord-023095-4dannjjm 371 8 during during IN cord-023095-4dannjjm 371 9 investigational investigational JJ cord-023095-4dannjjm 371 10 treatment treatment NN cord-023095-4dannjjm 371 11 of of IN cord-023095-4dannjjm 371 12 refractory refractory JJ cord-023095-4dannjjm 371 13 congestive congestive JJ cord-023095-4dannjjm 371 14 heart heart NN cord-023095-4dannjjm 371 15 failure failure NN cord-023095-4dannjjm 371 16 in in IN cord-023095-4dannjjm 371 17 humans human NNS cord-023095-4dannjjm 371 18 . . . cord-023095-4dannjjm 372 1 ADH ADH NNP cord-023095-4dannjjm 372 2 levels level NNS cord-023095-4dannjjm 372 3 have have VBP cord-023095-4dannjjm 372 4 been be VBN cord-023095-4dannjjm 372 5 only only RB cord-023095-4dannjjm 372 6 modestly modestly RB cord-023095-4dannjjm 372 7 investigated investigate VBN cord-023095-4dannjjm 372 8 in in IN cord-023095-4dannjjm 372 9 dogs dog NNS cord-023095-4dannjjm 372 10 with with IN cord-023095-4dannjjm 372 11 cardiac cardiac JJ cord-023095-4dannjjm 372 12 disease disease NN cord-023095-4dannjjm 372 13 , , , cord-023095-4dannjjm 372 14 primarily primarily RB cord-023095-4dannjjm 372 15 due due IN cord-023095-4dannjjm 372 16 to to IN cord-023095-4dannjjm 372 17 the the DT cord-023095-4dannjjm 372 18 technical technical JJ cord-023095-4dannjjm 372 19 difficulty difficulty NN cord-023095-4dannjjm 372 20 in in IN cord-023095-4dannjjm 372 21 measuring measure VBG cord-023095-4dannjjm 372 22 ADH ADH NNP cord-023095-4dannjjm 372 23 levels level NNS cord-023095-4dannjjm 372 24 via via IN cord-023095-4dannjjm 372 25 radioimmunoassay radioimmunoassay NN cord-023095-4dannjjm 372 26 . . . cord-023095-4dannjjm 373 1 Based base VBN cord-023095-4dannjjm 373 2 on on IN cord-023095-4dannjjm 373 3 the the DT cord-023095-4dannjjm 373 4 homologous homologous JJ cord-023095-4dannjjm 373 5 structure structure NN cord-023095-4dannjjm 373 6 of of IN cord-023095-4dannjjm 373 7 canine canine JJ cord-023095-4dannjjm 373 8 and and CC cord-023095-4dannjjm 373 9 human human JJ cord-023095-4dannjjm 373 10 ADH ADH NNP cord-023095-4dannjjm 373 11 , , , cord-023095-4dannjjm 373 12 we -PRON- PRP cord-023095-4dannjjm 373 13 aimed aim VBD cord-023095-4dannjjm 373 14 first first RB cord-023095-4dannjjm 373 15 to to TO cord-023095-4dannjjm 373 16 determine determine VB cord-023095-4dannjjm 373 17 the the DT cord-023095-4dannjjm 373 18 feasibility feasibility NN cord-023095-4dannjjm 373 19 of of IN cord-023095-4dannjjm 373 20 measuring measure VBG cord-023095-4dannjjm 373 21 ADH ADH NNP cord-023095-4dannjjm 373 22 in in IN cord-023095-4dannjjm 373 23 dog dog NN cord-023095-4dannjjm 373 24 plasma plasma NN cord-023095-4dannjjm 373 25 using use VBG cord-023095-4dannjjm 373 26 a a DT cord-023095-4dannjjm 373 27 human human JJ cord-023095-4dannjjm 373 28 ELISA ELISA NNP cord-023095-4dannjjm 373 29 kit kit NN cord-023095-4dannjjm 373 30 , , , cord-023095-4dannjjm 373 31 and and CC cord-023095-4dannjjm 373 32 secondly secondly RB cord-023095-4dannjjm 373 33 to to TO cord-023095-4dannjjm 373 34 investigate investigate VB cord-023095-4dannjjm 373 35 the the DT cord-023095-4dannjjm 373 36 level level NN cord-023095-4dannjjm 373 37 of of IN cord-023095-4dannjjm 373 38 ADH ADH NNP cord-023095-4dannjjm 373 39 in in IN cord-023095-4dannjjm 373 40 dogs dog NNS cord-023095-4dannjjm 373 41 with with IN cord-023095-4dannjjm 373 42 congestive congestive JJ cord-023095-4dannjjm 373 43 heart heart NN cord-023095-4dannjjm 373 44 failure failure NN cord-023095-4dannjjm 373 45 due due JJ cord-023095-4dannjjm 373 46 to to IN cord-023095-4dannjjm 373 47 acquired acquire VBN cord-023095-4dannjjm 373 48 cardiac cardiac JJ cord-023095-4dannjjm 373 49 disease disease NN cord-023095-4dannjjm 373 50 . . . cord-023095-4dannjjm 374 1 ELISA ELISA NNP cord-023095-4dannjjm 374 2 assay assay NNP cord-023095-4dannjjm 374 3 kit kit NNP cord-023095-4dannjjm 374 4 validation validation NN cord-023095-4dannjjm 374 5 was be VBD cord-023095-4dannjjm 374 6 performed perform VBN cord-023095-4dannjjm 374 7 using use VBG cord-023095-4dannjjm 374 8 six six CD cord-023095-4dannjjm 374 9 healthy healthy JJ cord-023095-4dannjjm 374 10 dogs dog NNS cord-023095-4dannjjm 374 11 with with IN cord-023095-4dannjjm 374 12 normal normal JJ cord-023095-4dannjjm 374 13 clinical clinical JJ cord-023095-4dannjjm 374 14 and and CC cord-023095-4dannjjm 374 15 echocardiographic echocardiographic JJ cord-023095-4dannjjm 374 16 examinations examination NNS cord-023095-4dannjjm 374 17 . . . cord-023095-4dannjjm 375 1 Pooled pool VBN cord-023095-4dannjjm 375 2 canine canine JJ cord-023095-4dannjjm 375 3 plasma plasma NN cord-023095-4dannjjm 375 4 was be VBD cord-023095-4dannjjm 375 5 spiked spike VBN cord-023095-4dannjjm 375 6 with with IN cord-023095-4dannjjm 375 7 synthetic synthetic JJ cord-023095-4dannjjm 375 8 ADH ADH NNP cord-023095-4dannjjm 375 9 and and CC cord-023095-4dannjjm 375 10 intra intra JJ cord-023095-4dannjjm 375 11 - - JJ cord-023095-4dannjjm 375 12 assay assay JJ cord-023095-4dannjjm 375 13 precision precision NN cord-023095-4dannjjm 375 14 , , , cord-023095-4dannjjm 375 15 dilutional dilutional JJ cord-023095-4dannjjm 375 16 parallelism parallelism NN cord-023095-4dannjjm 375 17 , , , cord-023095-4dannjjm 375 18 and and CC cord-023095-4dannjjm 375 19 linearity linearity NN cord-023095-4dannjjm 375 20 were be VBD cord-023095-4dannjjm 375 21 assessed assess VBN cord-023095-4dannjjm 375 22 . . . cord-023095-4dannjjm 376 1 To to TO cord-023095-4dannjjm 376 2 address address VB cord-023095-4dannjjm 376 3 the the DT cord-023095-4dannjjm 376 4 second second JJ cord-023095-4dannjjm 376 5 aim aim NN cord-023095-4dannjjm 376 6 of of IN cord-023095-4dannjjm 376 7 the the DT cord-023095-4dannjjm 376 8 study study NN cord-023095-4dannjjm 376 9 , , , cord-023095-4dannjjm 376 10 samples sample NNS cord-023095-4dannjjm 376 11 were be VBD cord-023095-4dannjjm 376 12 collected collect VBN cord-023095-4dannjjm 376 13 from from IN cord-023095-4dannjjm 376 14 normal normal JJ cord-023095-4dannjjm 376 15 dogs dog NNS cord-023095-4dannjjm 376 16 and and CC cord-023095-4dannjjm 376 17 dogs dog NNS cord-023095-4dannjjm 376 18 with with IN cord-023095-4dannjjm 376 19 heart heart NN cord-023095-4dannjjm 376 20 failure failure NN cord-023095-4dannjjm 376 21 due due JJ cord-023095-4dannjjm 376 22 to to IN cord-023095-4dannjjm 376 23 one one CD cord-023095-4dannjjm 376 24 of of IN cord-023095-4dannjjm 376 25 two two CD cord-023095-4dannjjm 376 26 types type NNS cord-023095-4dannjjm 376 27 of of IN cord-023095-4dannjjm 376 28 acquired acquire VBN cord-023095-4dannjjm 376 29 cardiac cardiac JJ cord-023095-4dannjjm 376 30 disease disease NN cord-023095-4dannjjm 376 31 : : : cord-023095-4dannjjm 376 32 chronic chronic JJ cord-023095-4dannjjm 376 33 degenerative degenerative JJ cord-023095-4dannjjm 376 34 valve valve NN cord-023095-4dannjjm 376 35 disease disease NN cord-023095-4dannjjm 376 36 ( ( -LRB- cord-023095-4dannjjm 376 37 CDVD CDVD NNP cord-023095-4dannjjm 376 38 ) ) -RRB- cord-023095-4dannjjm 376 39 or or CC cord-023095-4dannjjm 376 40 dilated dilated JJ cord-023095-4dannjjm 376 41 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 376 42 ( ( -LRB- cord-023095-4dannjjm 376 43 DCM DCM NNP cord-023095-4dannjjm 376 44 ) ) -RRB- cord-023095-4dannjjm 376 45 . . . cord-023095-4dannjjm 377 1 Patients patient NNS cord-023095-4dannjjm 377 2 underwent undergo VBD cord-023095-4dannjjm 377 3 clinical clinical JJ cord-023095-4dannjjm 377 4 , , , cord-023095-4dannjjm 377 5 radiographic radiographic JJ cord-023095-4dannjjm 377 6 , , , cord-023095-4dannjjm 377 7 and and CC cord-023095-4dannjjm 377 8 echocardiographic echocardiographic JJ cord-023095-4dannjjm 377 9 examination examination NN cord-023095-4dannjjm 377 10 to to TO cord-023095-4dannjjm 377 11 confirm confirm VB cord-023095-4dannjjm 377 12 diagnosis diagnosis NN cord-023095-4dannjjm 377 13 , , , cord-023095-4dannjjm 377 14 assess assess VB cord-023095-4dannjjm 377 15 severity severity NN cord-023095-4dannjjm 377 16 of of IN cord-023095-4dannjjm 377 17 disease disease NN cord-023095-4dannjjm 377 18 , , , cord-023095-4dannjjm 377 19 and and CC cord-023095-4dannjjm 377 20 determine determine VB cord-023095-4dannjjm 377 21 presence presence NN cord-023095-4dannjjm 377 22 of of IN cord-023095-4dannjjm 377 23 pulmonary pulmonary JJ cord-023095-4dannjjm 377 24 edema edema NN cord-023095-4dannjjm 377 25 . . . cord-023095-4dannjjm 378 1 Whole whole JJ cord-023095-4dannjjm 378 2 blood blood NN cord-023095-4dannjjm 378 3 was be VBD cord-023095-4dannjjm 378 4 collected collect VBN cord-023095-4dannjjm 378 5 into into IN cord-023095-4dannjjm 378 6 EDTA EDTA NNP cord-023095-4dannjjm 378 7 tubes tube NNS cord-023095-4dannjjm 378 8 containing contain VBG cord-023095-4dannjjm 378 9 protease protease NN cord-023095-4dannjjm 378 10 inhibitors inhibitor NNS cord-023095-4dannjjm 378 11 , , , cord-023095-4dannjjm 378 12 cold cold JJ cord-023095-4dannjjm 378 13 centrifuged centrifuge VBN cord-023095-4dannjjm 378 14 , , , cord-023095-4dannjjm 378 15 and and CC cord-023095-4dannjjm 378 16 plasma plasma NN cord-023095-4dannjjm 378 17 was be VBD cord-023095-4dannjjm 378 18 stored store VBN cord-023095-4dannjjm 378 19 at at IN cord-023095-4dannjjm 378 20 À801 À801 NNS cord-023095-4dannjjm 378 21 until until IN cord-023095-4dannjjm 378 22 analysis analysis NN cord-023095-4dannjjm 378 23 . . . cord-023095-4dannjjm 379 1 Following follow VBG cord-023095-4dannjjm 379 2 ether ether NN cord-023095-4dannjjm 379 3 extraction extraction NN cord-023095-4dannjjm 379 4 , , , cord-023095-4dannjjm 379 5 plasma plasma NN cord-023095-4dannjjm 379 6 ADH ADH NNP cord-023095-4dannjjm 379 7 in in IN cord-023095-4dannjjm 379 8 each each DT cord-023095-4dannjjm 379 9 sample sample NN cord-023095-4dannjjm 379 10 was be VBD cord-023095-4dannjjm 379 11 measured measure VBN cord-023095-4dannjjm 379 12 in in IN cord-023095-4dannjjm 379 13 duplicate duplicate NN cord-023095-4dannjjm 379 14 using use VBG cord-023095-4dannjjm 379 15 a a DT cord-023095-4dannjjm 379 16 human human JJ cord-023095-4dannjjm 379 17 ELISA ELISA NNP cord-023095-4dannjjm 379 18 kit kit NN cord-023095-4dannjjm 379 19 . . . cord-023095-4dannjjm 380 1 Statistical statistical JJ cord-023095-4dannjjm 380 2 analysis analysis NN cord-023095-4dannjjm 380 3 included include VBD cord-023095-4dannjjm 380 4 a a DT cord-023095-4dannjjm 380 5 D D NNP cord-023095-4dannjjm 380 6 - - HYPH cord-023095-4dannjjm 380 7 Agostino Agostino NNP cord-023095-4dannjjm 380 8 and and CC cord-023095-4dannjjm 380 9 Pearson Pearson NNP cord-023095-4dannjjm 380 10 test test VBP cord-023095-4dannjjm 380 11 for for IN cord-023095-4dannjjm 380 12 normality normality NN cord-023095-4dannjjm 380 13 ; ; : cord-023095-4dannjjm 380 14 group group NN cord-023095-4dannjjm 380 15 results result NNS cord-023095-4dannjjm 380 16 were be VBD cord-023095-4dannjjm 380 17 compared compare VBN cord-023095-4dannjjm 380 18 using use VBG cord-023095-4dannjjm 380 19 a a DT cord-023095-4dannjjm 380 20 nonparametric nonparametric JJ cord-023095-4dannjjm 380 21 Mann Mann NNP cord-023095-4dannjjm 380 22 - - HYPH cord-023095-4dannjjm 380 23 Whitney Whitney NNP cord-023095-4dannjjm 380 24 test test NN cord-023095-4dannjjm 380 25 . . . cord-023095-4dannjjm 381 1 ADH ADH NNP cord-023095-4dannjjm 381 2 was be VBD cord-023095-4dannjjm 381 3 measured measure VBN cord-023095-4dannjjm 381 4 in in IN cord-023095-4dannjjm 381 5 canine canine JJ cord-023095-4dannjjm 381 6 plasma plasma NN cord-023095-4dannjjm 381 7 using use VBG cord-023095-4dannjjm 381 8 the the DT cord-023095-4dannjjm 381 9 human human JJ cord-023095-4dannjjm 381 10 ELISA ELISA NNP cord-023095-4dannjjm 381 11 kit kit NN cord-023095-4dannjjm 381 12 with with IN cord-023095-4dannjjm 381 13 acceptable acceptable JJ cord-023095-4dannjjm 381 14 intra intra JJ cord-023095-4dannjjm 381 15 - - JJ cord-023095-4dannjjm 381 16 assay assay JJ cord-023095-4dannjjm 381 17 precision precision NN cord-023095-4dannjjm 381 18 , , , cord-023095-4dannjjm 381 19 linearity linearity NN cord-023095-4dannjjm 381 20 , , , cord-023095-4dannjjm 381 21 and and CC cord-023095-4dannjjm 381 22 dilutional dilutional JJ cord-023095-4dannjjm 381 23 parallelism parallelism NN cord-023095-4dannjjm 381 24 . . . cord-023095-4dannjjm 382 1 Intra intra JJ cord-023095-4dannjjm 382 2 - - JJ cord-023095-4dannjjm 382 3 assay assay JJ cord-023095-4dannjjm 382 4 coefficient coefficient NN cord-023095-4dannjjm 382 5 of of IN cord-023095-4dannjjm 382 6 variation variation NN cord-023095-4dannjjm 382 7 was be VBD cord-023095-4dannjjm 382 8 11 11 CD cord-023095-4dannjjm 382 9 % % NN cord-023095-4dannjjm 382 10 . . . cord-023095-4dannjjm 383 1 Twenty twenty CD cord-023095-4dannjjm 383 2 - - HYPH cord-023095-4dannjjm 383 3 four four CD cord-023095-4dannjjm 383 4 dogs dog NNS cord-023095-4dannjjm 383 5 were be VBD cord-023095-4dannjjm 383 6 recruited recruit VBN cord-023095-4dannjjm 383 7 for for IN cord-023095-4dannjjm 383 8 the the DT cord-023095-4dannjjm 383 9 second second JJ cord-023095-4dannjjm 383 10 phase phase NN cord-023095-4dannjjm 383 11 of of IN cord-023095-4dannjjm 383 12 the the DT cord-023095-4dannjjm 383 13 study study NN cord-023095-4dannjjm 383 14 . . . cord-023095-4dannjjm 384 1 Six six CD cord-023095-4dannjjm 384 2 normal normal JJ cord-023095-4dannjjm 384 3 dogs dog NNS cord-023095-4dannjjm 384 4 and and CC cord-023095-4dannjjm 384 5 twelve twelve CD cord-023095-4dannjjm 384 6 dogs dog NNS cord-023095-4dannjjm 384 7 with with IN cord-023095-4dannjjm 384 8 radiographic radiographic JJ cord-023095-4dannjjm 384 9 evidence evidence NN cord-023095-4dannjjm 384 10 of of IN cord-023095-4dannjjm 384 11 pulmonary pulmonary JJ cord-023095-4dannjjm 384 12 edema edema NN cord-023095-4dannjjm 384 13 due due IN cord-023095-4dannjjm 384 14 to to IN cord-023095-4dannjjm 384 15 either either CC cord-023095-4dannjjm 384 16 CDVD CDVD NNP cord-023095-4dannjjm 384 17 or or CC cord-023095-4dannjjm 384 18 DCM DCM NNP cord-023095-4dannjjm 384 19 were be VBD cord-023095-4dannjjm 384 20 selected select VBN cord-023095-4dannjjm 384 21 for for IN cord-023095-4dannjjm 384 22 participation participation NN cord-023095-4dannjjm 384 23 . . . cord-023095-4dannjjm 385 1 The the DT cord-023095-4dannjjm 385 2 remaining remain VBG cord-023095-4dannjjm 385 3 six six CD cord-023095-4dannjjm 385 4 dogs dog NNS cord-023095-4dannjjm 385 5 were be VBD cord-023095-4dannjjm 385 6 excluded exclude VBN cord-023095-4dannjjm 385 7 due due IN cord-023095-4dannjjm 385 8 to to IN cord-023095-4dannjjm 385 9 lack lack NN cord-023095-4dannjjm 385 10 of of IN cord-023095-4dannjjm 385 11 definitive definitive JJ cord-023095-4dannjjm 385 12 radiographic radiographic JJ cord-023095-4dannjjm 385 13 evidence evidence NN cord-023095-4dannjjm 385 14 of of IN cord-023095-4dannjjm 385 15 congestive congestive JJ cord-023095-4dannjjm 385 16 heart heart NN cord-023095-4dannjjm 385 17 failure failure NN cord-023095-4dannjjm 385 18 . . . cord-023095-4dannjjm 386 1 Median median JJ cord-023095-4dannjjm 386 2 ADH ADH NNP cord-023095-4dannjjm 386 3 values value NNS cord-023095-4dannjjm 386 4 were be VBD cord-023095-4dannjjm 386 5 3.67 3.67 CD cord-023095-4dannjjm 386 6 AE AE NNP cord-023095-4dannjjm 386 7 .38 .38 . cord-023095-4dannjjm 386 8 pg pg NN cord-023095-4dannjjm 386 9 / / SYM cord-023095-4dannjjm 386 10 mL ml NN cord-023095-4dannjjm 386 11 for for IN cord-023095-4dannjjm 386 12 the the DT cord-023095-4dannjjm 386 13 normal normal JJ cord-023095-4dannjjm 386 14 group group NN cord-023095-4dannjjm 386 15 ( ( -LRB- cord-023095-4dannjjm 386 16 n n NN cord-023095-4dannjjm 386 17 5 5 CD cord-023095-4dannjjm 386 18 6 6 CD cord-023095-4dannjjm 386 19 ) ) -RRB- cord-023095-4dannjjm 386 20 and and CC cord-023095-4dannjjm 386 21 6.155 6.155 CD cord-023095-4dannjjm 386 22 AE AE NNP cord-023095-4dannjjm 386 23 .94 .94 . cord-023095-4dannjjm 386 24 pg pg NN cord-023095-4dannjjm 386 25 / / SYM cord-023095-4dannjjm 386 26 mL ml NN cord-023095-4dannjjm 386 27 for for IN cord-023095-4dannjjm 386 28 the the DT cord-023095-4dannjjm 386 29 heart heart NN cord-023095-4dannjjm 386 30 failure failure NN cord-023095-4dannjjm 386 31 group group NNP cord-023095-4dannjjm 386 32 ( ( -LRB- cord-023095-4dannjjm 386 33 n n NN cord-023095-4dannjjm 386 34 5 5 CD cord-023095-4dannjjm 386 35 12 12 CD cord-023095-4dannjjm 386 36 ) ) -RRB- cord-023095-4dannjjm 386 37 . . . cord-023095-4dannjjm 387 1 Median median JJ cord-023095-4dannjjm 387 2 ADH ADH NNP cord-023095-4dannjjm 387 3 values value NNS cord-023095-4dannjjm 387 4 for for IN cord-023095-4dannjjm 387 5 the the DT cord-023095-4dannjjm 387 6 two two CD cord-023095-4dannjjm 387 7 groups group NNS cord-023095-4dannjjm 387 8 were be VBD cord-023095-4dannjjm 387 9 statistically statistically RB cord-023095-4dannjjm 387 10 different different JJ cord-023095-4dannjjm 387 11 ( ( -LRB- cord-023095-4dannjjm 387 12 p p NN cord-023095-4dannjjm 387 13 5 5 CD cord-023095-4dannjjm 387 14 0.0057 0.0057 CD cord-023095-4dannjjm 387 15 ) ) -RRB- cord-023095-4dannjjm 387 16 . . . cord-023095-4dannjjm 388 1 Our -PRON- PRP$ cord-023095-4dannjjm 388 2 preliminary preliminary JJ cord-023095-4dannjjm 388 3 results result NNS cord-023095-4dannjjm 388 4 indicate indicate VBP cord-023095-4dannjjm 388 5 that that IN cord-023095-4dannjjm 388 6 measuring measure VBG cord-023095-4dannjjm 388 7 canine canine JJ cord-023095-4dannjjm 388 8 ADH ADH NNP cord-023095-4dannjjm 388 9 using use VBG cord-023095-4dannjjm 388 10 a a DT cord-023095-4dannjjm 388 11 human human JJ cord-023095-4dannjjm 388 12 ELISA ELISA NNP cord-023095-4dannjjm 388 13 kit kit NN cord-023095-4dannjjm 388 14 is be VBZ cord-023095-4dannjjm 388 15 feasible feasible JJ cord-023095-4dannjjm 388 16 and and CC cord-023095-4dannjjm 388 17 provides provide VBZ cord-023095-4dannjjm 388 18 results result NNS cord-023095-4dannjjm 388 19 with with IN cord-023095-4dannjjm 388 20 an an DT cord-023095-4dannjjm 388 21 acceptable acceptable JJ cord-023095-4dannjjm 388 22 coefficient coefficient NN cord-023095-4dannjjm 388 23 of of IN cord-023095-4dannjjm 388 24 variation variation NN cord-023095-4dannjjm 388 25 . . . cord-023095-4dannjjm 389 1 We -PRON- PRP cord-023095-4dannjjm 389 2 also also RB cord-023095-4dannjjm 389 3 showed show VBD cord-023095-4dannjjm 389 4 that that IN cord-023095-4dannjjm 389 5 dogs dog NNS cord-023095-4dannjjm 389 6 with with IN cord-023095-4dannjjm 389 7 congestive congestive JJ cord-023095-4dannjjm 389 8 heart heart NN cord-023095-4dannjjm 389 9 failure failure NN cord-023095-4dannjjm 389 10 due due JJ cord-023095-4dannjjm 389 11 to to IN cord-023095-4dannjjm 389 12 CDVD CDVD NNP cord-023095-4dannjjm 389 13 and and CC cord-023095-4dannjjm 389 14 DCM DCM NNP cord-023095-4dannjjm 389 15 have have VBP cord-023095-4dannjjm 389 16 elevated elevate VBN cord-023095-4dannjjm 389 17 ADH ADH NNP cord-023095-4dannjjm 389 18 levels level NNS cord-023095-4dannjjm 389 19 in in IN cord-023095-4dannjjm 389 20 comparison comparison NN cord-023095-4dannjjm 389 21 to to IN cord-023095-4dannjjm 389 22 normal normal JJ cord-023095-4dannjjm 389 23 dogs dog NNS cord-023095-4dannjjm 389 24 . . . cord-023095-4dannjjm 390 1 Our -PRON- PRP$ cord-023095-4dannjjm 390 2 findings finding NNS cord-023095-4dannjjm 390 3 motivate motivate VBP cord-023095-4dannjjm 390 4 further further JJ cord-023095-4dannjjm 390 5 investigation investigation NN cord-023095-4dannjjm 390 6 to to TO cord-023095-4dannjjm 390 7 assess assess VB cord-023095-4dannjjm 390 8 the the DT cord-023095-4dannjjm 390 9 degree degree NN cord-023095-4dannjjm 390 10 of of IN cord-023095-4dannjjm 390 11 plasma plasma NN cord-023095-4dannjjm 390 12 ADH ADH NNP cord-023095-4dannjjm 390 13 level level NN cord-023095-4dannjjm 390 14 elevation elevation NN cord-023095-4dannjjm 390 15 and and CC cord-023095-4dannjjm 390 16 the the DT cord-023095-4dannjjm 390 17 possible possible JJ cord-023095-4dannjjm 390 18 use use NN cord-023095-4dannjjm 390 19 of of IN cord-023095-4dannjjm 390 20 ADH ADH NNP cord-023095-4dannjjm 390 21 antagonists antagonist NNS cord-023095-4dannjjm 390 22 as as IN cord-023095-4dannjjm 390 23 an an DT cord-023095-4dannjjm 390 24 adjunct adjunct JJ cord-023095-4dannjjm 390 25 treatment treatment NN cord-023095-4dannjjm 390 26 for for IN cord-023095-4dannjjm 390 27 refractory refractory JJ cord-023095-4dannjjm 390 28 congestive congestive JJ cord-023095-4dannjjm 390 29 heart heart NN cord-023095-4dannjjm 390 30 failure failure NN cord-023095-4dannjjm 390 31 in in IN cord-023095-4dannjjm 390 32 dogs dog NNS cord-023095-4dannjjm 390 33 . . . cord-023095-4dannjjm 391 1 Aortic aortic JJ cord-023095-4dannjjm 391 2 thromboembolism thromboembolism NN cord-023095-4dannjjm 391 3 ( ( -LRB- cord-023095-4dannjjm 391 4 ATE ate NN cord-023095-4dannjjm 391 5 ) ) -RRB- cord-023095-4dannjjm 391 6 occurs occur VBZ cord-023095-4dannjjm 391 7 in in IN cord-023095-4dannjjm 391 8 both both DT cord-023095-4dannjjm 391 9 cats cat NNS cord-023095-4dannjjm 391 10 and and CC cord-023095-4dannjjm 391 11 dogs dog NNS cord-023095-4dannjjm 391 12 . . . cord-023095-4dannjjm 392 1 Whereas whereas IN cord-023095-4dannjjm 392 2 ATE eat VBD cord-023095-4dannjjm 392 3 in in IN cord-023095-4dannjjm 392 4 cats cat NNS cord-023095-4dannjjm 392 5 is be VBZ cord-023095-4dannjjm 392 6 strongly strongly RB cord-023095-4dannjjm 392 7 associated associate VBN cord-023095-4dannjjm 392 8 with with IN cord-023095-4dannjjm 392 9 structural structural JJ cord-023095-4dannjjm 392 10 heart heart NN cord-023095-4dannjjm 392 11 disease disease NN cord-023095-4dannjjm 392 12 and and CC cord-023095-4dannjjm 392 13 typically typically RB cord-023095-4dannjjm 392 14 has have VBZ cord-023095-4dannjjm 392 15 an an DT cord-023095-4dannjjm 392 16 acute acute JJ cord-023095-4dannjjm 392 17 catastrophic catastrophic JJ cord-023095-4dannjjm 392 18 presentation presentation NN cord-023095-4dannjjm 392 19 ; ; : cord-023095-4dannjjm 392 20 the the DT cord-023095-4dannjjm 392 21 pathogenesis pathogenesis NN cord-023095-4dannjjm 392 22 and and CC cord-023095-4dannjjm 392 23 presentation presentation NN cord-023095-4dannjjm 392 24 of of IN cord-023095-4dannjjm 392 25 ATE eat VBD cord-023095-4dannjjm 392 26 in in IN cord-023095-4dannjjm 392 27 dogs dog NNS cord-023095-4dannjjm 392 28 is be VBZ cord-023095-4dannjjm 392 29 less less RBR cord-023095-4dannjjm 392 30 well well RB cord-023095-4dannjjm 392 31 known known JJ cord-023095-4dannjjm 392 32 or or CC cord-023095-4dannjjm 392 33 understood understand VBN cord-023095-4dannjjm 392 34 . . . cord-023095-4dannjjm 393 1 Further further RB cord-023095-4dannjjm 393 2 , , , cord-023095-4dannjjm 393 3 an an DT cord-023095-4dannjjm 393 4 effective effective JJ cord-023095-4dannjjm 393 5 antithrombotic antithrombotic JJ cord-023095-4dannjjm 393 6 strategy strategy NN cord-023095-4dannjjm 393 7 for for IN cord-023095-4dannjjm 393 8 ATE eat VBD cord-023095-4dannjjm 393 9 in in IN cord-023095-4dannjjm 393 10 dogs dog NNS cord-023095-4dannjjm 393 11 has have VBZ cord-023095-4dannjjm 393 12 not not RB cord-023095-4dannjjm 393 13 been be VBN cord-023095-4dannjjm 393 14 reported report VBN cord-023095-4dannjjm 393 15 . . . cord-023095-4dannjjm 394 1 Medical medical JJ cord-023095-4dannjjm 394 2 records record NNS cord-023095-4dannjjm 394 3 of of IN cord-023095-4dannjjm 394 4 dogs dog NNS cord-023095-4dannjjm 394 5 diagnosed diagnose VBN cord-023095-4dannjjm 394 6 with with IN cord-023095-4dannjjm 394 7 ATE eat VBD cord-023095-4dannjjm 394 8 between between IN cord-023095-4dannjjm 394 9 2003 2003 CD cord-023095-4dannjjm 394 10 and and CC cord-023095-4dannjjm 394 11 2010 2010 CD cord-023095-4dannjjm 394 12 were be VBD cord-023095-4dannjjm 394 13 examined examine VBN cord-023095-4dannjjm 394 14 retrospectively retrospectively RB cord-023095-4dannjjm 394 15 . . . cord-023095-4dannjjm 395 1 Diagnosis diagnosis NN cord-023095-4dannjjm 395 2 of of IN cord-023095-4dannjjm 395 3 ATE ATE NNP cord-023095-4dannjjm 395 4 was be VBD cord-023095-4dannjjm 395 5 based base VBN cord-023095-4dannjjm 395 6 on on IN cord-023095-4dannjjm 395 7 ultrasonography ultrasonography NN cord-023095-4dannjjm 395 8 , , , cord-023095-4dannjjm 395 9 Doppler Doppler NNP cord-023095-4dannjjm 395 10 flow flow NN cord-023095-4dannjjm 395 11 studies study NNS cord-023095-4dannjjm 395 12 , , , cord-023095-4dannjjm 395 13 and and CC cord-023095-4dannjjm 395 14 diminished diminish VBD cord-023095-4dannjjm 395 15 or or CC cord-023095-4dannjjm 395 16 absent absent JJ cord-023095-4dannjjm 395 17 femoral femoral JJ cord-023095-4dannjjm 395 18 pulses pulse NNS cord-023095-4dannjjm 395 19 . . . cord-023095-4dannjjm 396 1 Dogs dog NNS cord-023095-4dannjjm 396 2 were be VBD cord-023095-4dannjjm 396 3 treated treat VBN cord-023095-4dannjjm 396 4 with with IN cord-023095-4dannjjm 396 5 various various JJ cord-023095-4dannjjm 396 6 acute acute JJ cord-023095-4dannjjm 396 7 and and CC cord-023095-4dannjjm 396 8 chronic chronic JJ cord-023095-4dannjjm 396 9 antithrombotic antithrombotic JJ cord-023095-4dannjjm 396 10 therapies therapy NNS cord-023095-4dannjjm 396 11 . . . cord-023095-4dannjjm 397 1 The the DT cord-023095-4dannjjm 397 2 severity severity NN cord-023095-4dannjjm 397 3 of of IN cord-023095-4dannjjm 397 4 ambulatory ambulatory JJ cord-023095-4dannjjm 397 5 dysfunction dysfunction NN cord-023095-4dannjjm 397 6 was be VBD cord-023095-4dannjjm 397 7 graded grade VBN cord-023095-4dannjjm 397 8 as as IN cord-023095-4dannjjm 397 9 none none NN cord-023095-4dannjjm 397 10 , , , cord-023095-4dannjjm 397 11 mild mild JJ cord-023095-4dannjjm 397 12 , , , cord-023095-4dannjjm 397 13 moderate moderate JJ cord-023095-4dannjjm 397 14 , , , cord-023095-4dannjjm 397 15 severe severe JJ cord-023095-4dannjjm 397 16 , , , cord-023095-4dannjjm 397 17 or or CC cord-023095-4dannjjm 397 18 non non JJ cord-023095-4dannjjm 397 19 - - JJ cord-023095-4dannjjm 397 20 ambulatory ambulatory JJ cord-023095-4dannjjm 397 21 at at IN cord-023095-4dannjjm 397 22 presentation presentation NN cord-023095-4dannjjm 397 23 and and CC cord-023095-4dannjjm 397 24 after after IN cord-023095-4dannjjm 397 25 therapy therapy NN cord-023095-4dannjjm 397 26 . . . cord-023095-4dannjjm 398 1 A a DT cord-023095-4dannjjm 398 2 cohort cohort NN cord-023095-4dannjjm 398 3 of of IN cord-023095-4dannjjm 398 4 dogs dog NNS cord-023095-4dannjjm 398 5 in in IN cord-023095-4dannjjm 398 6 this this DT cord-023095-4dannjjm 398 7 study study NN cord-023095-4dannjjm 398 8 received receive VBD cord-023095-4dannjjm 398 9 a a DT cord-023095-4dannjjm 398 10 standardized standardized JJ cord-023095-4dannjjm 398 11 protocol protocol NN cord-023095-4dannjjm 398 12 of of IN cord-023095-4dannjjm 398 13 chronic chronic JJ cord-023095-4dannjjm 398 14 warfarin warfarin NN cord-023095-4dannjjm 398 15 therapy therapy NN cord-023095-4dannjjm 398 16 with with IN cord-023095-4dannjjm 398 17 or or CC cord-023095-4dannjjm 398 18 without without IN cord-023095-4dannjjm 398 19 antiplatelet antiplatelet JJ cord-023095-4dannjjm 398 20 drugs drug NNS cord-023095-4dannjjm 398 21 . . . cord-023095-4dannjjm 399 1 Target target VB cord-023095-4dannjjm 399 2 international international JJ cord-023095-4dannjjm 399 3 normalized normalize VBN cord-023095-4dannjjm 399 4 ratio ratio NN cord-023095-4dannjjm 399 5 for for IN cord-023095-4dannjjm 399 6 warfarin warfarin NN cord-023095-4dannjjm 399 7 therapy therapy NN cord-023095-4dannjjm 399 8 was be VBD cord-023095-4dannjjm 399 9 2 2 CD cord-023095-4dannjjm 399 10 to to IN cord-023095-4dannjjm 399 11 3 3 CD cord-023095-4dannjjm 399 12 . . . cord-023095-4dannjjm 400 1 Twenty twenty CD cord-023095-4dannjjm 400 2 - - HYPH cord-023095-4dannjjm 400 3 six six CD cord-023095-4dannjjm 400 4 dogs dog NNS cord-023095-4dannjjm 400 5 were be VBD cord-023095-4dannjjm 400 6 diagnosed diagnose VBN cord-023095-4dannjjm 400 7 with with IN cord-023095-4dannjjm 400 8 ATE ATE NNP cord-023095-4dannjjm 400 9 . . . cord-023095-4dannjjm 401 1 All all DT cord-023095-4dannjjm 401 2 had have VBD cord-023095-4dannjjm 401 3 an an DT cord-023095-4dannjjm 401 4 apparent apparent JJ cord-023095-4dannjjm 401 5 mural mural JJ cord-023095-4dannjjm 401 6 aortic aortic JJ cord-023095-4dannjjm 401 7 thrombus thrombus NN cord-023095-4dannjjm 401 8 caudal caudal RB cord-023095-4dannjjm 401 9 to to IN cord-023095-4dannjjm 401 10 the the DT cord-023095-4dannjjm 401 11 renal renal JJ cord-023095-4dannjjm 401 12 arteries artery NNS cord-023095-4dannjjm 401 13 with with IN cord-023095-4dannjjm 401 14 most most RBS cord-023095-4dannjjm 401 15 having have VBG cord-023095-4dannjjm 401 16 evidence evidence NN cord-023095-4dannjjm 401 17 of of IN cord-023095-4dannjjm 401 18 embolization embolization NN cord-023095-4dannjjm 401 19 to to IN cord-023095-4dannjjm 401 20 the the DT cord-023095-4dannjjm 401 21 iliac iliac JJ cord-023095-4dannjjm 401 22 and and CC cord-023095-4dannjjm 401 23 femoral femoral JJ cord-023095-4dannjjm 401 24 arteries artery NNS cord-023095-4dannjjm 401 25 . . . cord-023095-4dannjjm 402 1 None none NN cord-023095-4dannjjm 402 2 had have VBD cord-023095-4dannjjm 402 3 structural structural JJ cord-023095-4dannjjm 402 4 heart heart NN cord-023095-4dannjjm 402 5 disease disease NN cord-023095-4dannjjm 402 6 at at IN cord-023095-4dannjjm 402 7 diagnosis diagnosis NN cord-023095-4dannjjm 402 8 . . . cord-023095-4dannjjm 403 1 Twenty twenty CD cord-023095-4dannjjm 403 2 dogs dog NNS cord-023095-4dannjjm 403 3 ( ( -LRB- cord-023095-4dannjjm 403 4 77 77 CD cord-023095-4dannjjm 403 5 % % NN cord-023095-4dannjjm 403 6 ) ) -RRB- cord-023095-4dannjjm 403 7 were be VBD cord-023095-4dannjjm 403 8 still still RB cord-023095-4dannjjm 403 9 ambulatory ambulatory JJ cord-023095-4dannjjm 403 10 at at IN cord-023095-4dannjjm 403 11 diagnosis diagnosis NN cord-023095-4dannjjm 403 12 . . . cord-023095-4dannjjm 404 1 The the DT cord-023095-4dannjjm 404 2 median median JJ cord-023095-4dannjjm 404 3 duration duration NN cord-023095-4dannjjm 404 4 of of IN cord-023095-4dannjjm 404 5 ambulatory ambulatory JJ cord-023095-4dannjjm 404 6 dysfunction dysfunction NN cord-023095-4dannjjm 404 7 prior prior RB cord-023095-4dannjjm 404 8 to to IN cord-023095-4dannjjm 404 9 presentation presentation NN cord-023095-4dannjjm 404 10 was be VBD cord-023095-4dannjjm 404 11 7.8 7.8 CD cord-023095-4dannjjm 404 12 weeks week NNS cord-023095-4dannjjm 405 1 ( ( -LRB- cord-023095-4dannjjm 405 2 range range NN cord-023095-4dannjjm 405 3 1 1 CD cord-023095-4dannjjm 405 4 day day NN cord-023095-4dannjjm 405 5 -52 -52 CD cord-023095-4dannjjm 405 6 weeks week NNS cord-023095-4dannjjm 405 7 ) ) -RRB- cord-023095-4dannjjm 405 8 . . . cord-023095-4dannjjm 406 1 A a DT cord-023095-4dannjjm 406 2 majority majority NN cord-023095-4dannjjm 406 3 of of IN cord-023095-4dannjjm 406 4 dogs dog NNS cord-023095-4dannjjm 406 5 ( ( -LRB- cord-023095-4dannjjm 406 6 58 58 CD cord-023095-4dannjjm 406 7 % % NN cord-023095-4dannjjm 406 8 ) ) -RRB- cord-023095-4dannjjm 406 9 had have VBD cord-023095-4dannjjm 406 10 no no DT cord-023095-4dannjjm 406 11 concurrent concurrent JJ cord-023095-4dannjjm 406 12 conditions condition NNS cord-023095-4dannjjm 406 13 at at IN cord-023095-4dannjjm 406 14 diagnosis diagnosis NN cord-023095-4dannjjm 406 15 . . . cord-023095-4dannjjm 407 1 Nine nine CD cord-023095-4dannjjm 407 2 dogs dog NNS cord-023095-4dannjjm 407 3 ( ( -LRB- cord-023095-4dannjjm 407 4 33 33 CD cord-023095-4dannjjm 407 5 % % NN cord-023095-4dannjjm 407 6 ) ) -RRB- cord-023095-4dannjjm 407 7 had have VBD cord-023095-4dannjjm 407 8 protein protein NN cord-023095-4dannjjm 407 9 - - HYPH cord-023095-4dannjjm 407 10 losing lose VBG cord-023095-4dannjjm 407 11 nephropathy nephropathy NN cord-023095-4dannjjm 407 12 . . . cord-023095-4dannjjm 408 1 Four four CD cord-023095-4dannjjm 408 2 dogs dog NNS cord-023095-4dannjjm 408 3 ( ( -LRB- cord-023095-4dannjjm 408 4 15 15 CD cord-023095-4dannjjm 408 5 % % NN cord-023095-4dannjjm 408 6 ) ) -RRB- cord-023095-4dannjjm 408 7 were be VBD cord-023095-4dannjjm 408 8 hypothyroid hypothyroid JJ cord-023095-4dannjjm 408 9 . . . cord-023095-4dannjjm 409 1 Fourteen fourteen CD cord-023095-4dannjjm 409 2 dogs dog NNS cord-023095-4dannjjm 409 3 were be VBD cord-023095-4dannjjm 409 4 treated treat VBN cord-023095-4dannjjm 409 5 with with IN cord-023095-4dannjjm 409 6 a a DT cord-023095-4dannjjm 409 7 standard standard JJ cord-023095-4dannjjm 409 8 warfarin warfarin NN cord-023095-4dannjjm 409 9 protocol protocol NN cord-023095-4dannjjm 409 10 for for IN cord-023095-4dannjjm 409 11 a a DT cord-023095-4dannjjm 409 12 median median JJ cord-023095-4dannjjm 409 13 period period NN cord-023095-4dannjjm 409 14 of of IN cord-023095-4dannjjm 409 15 22.9 22.9 CD cord-023095-4dannjjm 409 16 months month NNS cord-023095-4dannjjm 409 17 ( ( -LRB- cord-023095-4dannjjm 409 18 range range VBP cord-023095-4dannjjm 409 19 0.5 0.5 CD cord-023095-4dannjjm 409 20 - - HYPH cord-023095-4dannjjm 409 21 53 53 CD cord-023095-4dannjjm 409 22 months month NNS cord-023095-4dannjjm 409 23 ) ) -RRB- cord-023095-4dannjjm 409 24 . . . cord-023095-4dannjjm 410 1 Eight eight CD cord-023095-4dannjjm 410 2 dogs dog NNS cord-023095-4dannjjm 410 3 were be VBD cord-023095-4dannjjm 410 4 treated treat VBN cord-023095-4dannjjm 410 5 concurrently concurrently RB cord-023095-4dannjjm 410 6 with with IN cord-023095-4dannjjm 410 7 aspirin aspirin NN cord-023095-4dannjjm 410 8 , , , cord-023095-4dannjjm 410 9 2 2 CD cord-023095-4dannjjm 410 10 dogs dog NNS cord-023095-4dannjjm 410 11 were be VBD cord-023095-4dannjjm 410 12 treated treat VBN cord-023095-4dannjjm 410 13 concurrently concurrently RB cord-023095-4dannjjm 410 14 with with IN cord-023095-4dannjjm 410 15 clopidogrel clopidogrel NN cord-023095-4dannjjm 410 16 , , , cord-023095-4dannjjm 410 17 and and CC cord-023095-4dannjjm 410 18 4 4 CD cord-023095-4dannjjm 410 19 dogs dog NNS cord-023095-4dannjjm 410 20 were be VBD cord-023095-4dannjjm 410 21 treated treat VBN cord-023095-4dannjjm 410 22 with with IN cord-023095-4dannjjm 410 23 warfarin warfarin NN cord-023095-4dannjjm 410 24 only only RB cord-023095-4dannjjm 410 25 . . . cord-023095-4dannjjm 411 1 Ambulatory ambulatory JJ cord-023095-4dannjjm 411 2 function function NN cord-023095-4dannjjm 411 3 improved improve VBN cord-023095-4dannjjm 411 4 between between IN cord-023095-4dannjjm 411 5 1 1 CD cord-023095-4dannjjm 411 6 and and CC cord-023095-4dannjjm 411 7 3 3 CD cord-023095-4dannjjm 411 8 grades grade NNS cord-023095-4dannjjm 411 9 in in IN cord-023095-4dannjjm 411 10 dogs dog NNS cord-023095-4dannjjm 411 11 treated treat VBN cord-023095-4dannjjm 411 12 with with IN cord-023095-4dannjjm 411 13 chronic chronic JJ cord-023095-4dannjjm 411 14 warfarin warfarin NN cord-023095-4dannjjm 411 15 . . . cord-023095-4dannjjm 412 1 The the DT cord-023095-4dannjjm 412 2 median median JJ cord-023095-4dannjjm 412 3 period period NN cord-023095-4dannjjm 412 4 until until IN cord-023095-4dannjjm 412 5 clinical clinical JJ cord-023095-4dannjjm 412 6 improvement improvement NN cord-023095-4dannjjm 412 7 was be VBD cord-023095-4dannjjm 412 8 13.9 13.9 CD cord-023095-4dannjjm 412 9 days day NNS cord-023095-4dannjjm 412 10 ( ( -LRB- cord-023095-4dannjjm 412 11 range range NNP cord-023095-4dannjjm 412 12 2 2 CD cord-023095-4dannjjm 412 13 - - SYM cord-023095-4dannjjm 412 14 49 49 CD cord-023095-4dannjjm 412 15 days day NNS cord-023095-4dannjjm 412 16 ) ) -RRB- cord-023095-4dannjjm 412 17 . . . cord-023095-4dannjjm 413 1 Two two CD cord-023095-4dannjjm 413 2 dogs dog NNS cord-023095-4dannjjm 413 3 treated treat VBN cord-023095-4dannjjm 413 4 with with IN cord-023095-4dannjjm 413 5 chronic chronic JJ cord-023095-4dannjjm 413 6 warfarin warfarin NN cord-023095-4dannjjm 413 7 therapy therapy NN cord-023095-4dannjjm 413 8 had have VBD cord-023095-4dannjjm 413 9 documented document VBN cord-023095-4dannjjm 413 10 resolution resolution NN cord-023095-4dannjjm 413 11 of of IN cord-023095-4dannjjm 413 12 ATE ATE NNP cord-023095-4dannjjm 413 13 , , , cord-023095-4dannjjm 413 14 and and CC cord-023095-4dannjjm 413 15 5 5 CD cord-023095-4dannjjm 413 16 dogs dog NNS cord-023095-4dannjjm 413 17 had have VBD cord-023095-4dannjjm 413 18 complete complete JJ cord-023095-4dannjjm 413 19 resolution resolution NN cord-023095-4dannjjm 413 20 of of IN cord-023095-4dannjjm 413 21 ambulatory ambulatory JJ cord-023095-4dannjjm 413 22 dysfunction dysfunction NN cord-023095-4dannjjm 413 23 . . . cord-023095-4dannjjm 414 1 None none NN cord-023095-4dannjjm 414 2 of of IN cord-023095-4dannjjm 414 3 the the DT cord-023095-4dannjjm 414 4 14 14 CD cord-023095-4dannjjm 414 5 dogs dog NNS cord-023095-4dannjjm 414 6 treated treat VBN cord-023095-4dannjjm 414 7 with with IN cord-023095-4dannjjm 414 8 chronic chronic JJ cord-023095-4dannjjm 414 9 warfarin warfarin NN cord-023095-4dannjjm 414 10 became become VBD cord-023095-4dannjjm 414 11 nonambulatory nonambulatory NNP cord-023095-4dannjjm 414 12 , , , cord-023095-4dannjjm 414 13 died die VBD cord-023095-4dannjjm 414 14 , , , cord-023095-4dannjjm 414 15 or or CC cord-023095-4dannjjm 414 16 underwent undergo VBD cord-023095-4dannjjm 414 17 euthanasia euthanasia JJ cord-023095-4dannjjm 414 18 because because IN cord-023095-4dannjjm 414 19 of of IN cord-023095-4dannjjm 414 20 ATE ate NN cord-023095-4dannjjm 414 21 . . . cord-023095-4dannjjm 415 1 The the DT cord-023095-4dannjjm 415 2 median median JJ cord-023095-4dannjjm 415 3 period period NN cord-023095-4dannjjm 415 4 of of IN cord-023095-4dannjjm 415 5 freedom freedom NN cord-023095-4dannjjm 415 6 from from IN cord-023095-4dannjjm 415 7 an an DT cord-023095-4dannjjm 415 8 adverse adverse JJ cord-023095-4dannjjm 415 9 event event NN cord-023095-4dannjjm 415 10 was be VBD cord-023095-4dannjjm 415 11 24.2 24.2 CD cord-023095-4dannjjm 415 12 months month NNS cord-023095-4dannjjm 415 13 . . . cord-023095-4dannjjm 416 1 No no DT cord-023095-4dannjjm 416 2 serious serious JJ cord-023095-4dannjjm 416 3 hemorrhagic hemorrhagic JJ cord-023095-4dannjjm 416 4 events event NNS cord-023095-4dannjjm 416 5 were be VBD cord-023095-4dannjjm 416 6 reported report VBN cord-023095-4dannjjm 416 7 . . . cord-023095-4dannjjm 417 1 Four four CD cord-023095-4dannjjm 417 2 dogs dog NNS cord-023095-4dannjjm 417 3 were be VBD cord-023095-4dannjjm 417 4 treated treat VBN cord-023095-4dannjjm 417 5 with with IN cord-023095-4dannjjm 417 6 tPA tPA NNP cord-023095-4dannjjm 417 7 . . . cord-023095-4dannjjm 418 1 Three three CD cord-023095-4dannjjm 418 2 of of IN cord-023095-4dannjjm 418 3 these these DT cord-023095-4dannjjm 418 4 had have VBD cord-023095-4dannjjm 418 5 an an DT cord-023095-4dannjjm 418 6 unfavorable unfavorable JJ cord-023095-4dannjjm 418 7 outcome outcome NN cord-023095-4dannjjm 418 8 . . . cord-023095-4dannjjm 419 1 Two two CD cord-023095-4dannjjm 419 2 dogs dog NNS cord-023095-4dannjjm 419 3 were be VBD cord-023095-4dannjjm 419 4 ambulatory ambulatory JJ cord-023095-4dannjjm 419 5 before before IN cord-023095-4dannjjm 419 6 tPA tPA NNP cord-023095-4dannjjm 419 7 and and CC cord-023095-4dannjjm 419 8 become become VB cord-023095-4dannjjm 419 9 non non JJ cord-023095-4dannjjm 419 10 - - JJ cord-023095-4dannjjm 419 11 ambulatory ambulatory JJ cord-023095-4dannjjm 419 12 after after IN cord-023095-4dannjjm 419 13 treatment treatment NN cord-023095-4dannjjm 419 14 . . . cord-023095-4dannjjm 420 1 Two two CD cord-023095-4dannjjm 420 2 dogs dog NNS cord-023095-4dannjjm 420 3 underwent undergo VBD cord-023095-4dannjjm 420 4 surgical surgical JJ cord-023095-4dannjjm 420 5 thrombectomy thrombectomy NN cord-023095-4dannjjm 420 6 . . . cord-023095-4dannjjm 421 1 One one PRP cord-023095-4dannjjm 421 2 had have VBD cord-023095-4dannjjm 421 3 a a DT cord-023095-4dannjjm 421 4 favorable favorable JJ cord-023095-4dannjjm 421 5 outcome outcome NN cord-023095-4dannjjm 421 6 until until IN cord-023095-4dannjjm 421 7 ATE eat VBD cord-023095-4dannjjm 421 8 recurred recur VBN cord-023095-4dannjjm 421 9 14 14 CD cord-023095-4dannjjm 421 10 months month NNS cord-023095-4dannjjm 421 11 after after IN cord-023095-4dannjjm 421 12 surgery surgery NN cord-023095-4dannjjm 421 13 . . . cord-023095-4dannjjm 422 1 In in IN cord-023095-4dannjjm 422 2 conclusion conclusion NN cord-023095-4dannjjm 422 3 , , , cord-023095-4dannjjm 422 4 the the DT cord-023095-4dannjjm 422 5 pathogenesis pathogenesis NN cord-023095-4dannjjm 422 6 of of IN cord-023095-4dannjjm 422 7 ATE eat VBD cord-023095-4dannjjm 422 8 in in IN cord-023095-4dannjjm 422 9 dogs dog NNS cord-023095-4dannjjm 422 10 is be VBZ cord-023095-4dannjjm 422 11 not not RB cord-023095-4dannjjm 422 12 associated associate VBN cord-023095-4dannjjm 422 13 with with IN cord-023095-4dannjjm 422 14 structural structural JJ cord-023095-4dannjjm 422 15 heart heart NN cord-023095-4dannjjm 422 16 disease disease NN cord-023095-4dannjjm 422 17 or or CC cord-023095-4dannjjm 422 18 left left JJ cord-023095-4dannjjm 422 19 atrial atrial JJ cord-023095-4dannjjm 422 20 thrombus thrombus NN cord-023095-4dannjjm 422 21 formation formation NN cord-023095-4dannjjm 422 22 . . . cord-023095-4dannjjm 423 1 The the DT cord-023095-4dannjjm 423 2 presentation presentation NN cord-023095-4dannjjm 423 3 tends tend VBZ cord-023095-4dannjjm 423 4 to to TO cord-023095-4dannjjm 423 5 be be VB cord-023095-4dannjjm 423 6 for for IN cord-023095-4dannjjm 423 7 chronic chronic JJ cord-023095-4dannjjm 423 8 ambulatory ambulatory JJ cord-023095-4dannjjm 423 9 dysfunction dysfunction NN cord-023095-4dannjjm 423 10 . . . cord-023095-4dannjjm 424 1 Most Most JJS cord-023095-4dannjjm 424 2 dogs dog NNS cord-023095-4dannjjm 424 3 are be VBP cord-023095-4dannjjm 424 4 still still RB cord-023095-4dannjjm 424 5 ambulatory ambulatory JJ cord-023095-4dannjjm 424 6 at at IN cord-023095-4dannjjm 424 7 presentation presentation NN cord-023095-4dannjjm 424 8 . . . cord-023095-4dannjjm 425 1 Warfarin warfarin UH cord-023095-4dannjjm 425 2 , , , cord-023095-4dannjjm 425 3 with with IN cord-023095-4dannjjm 425 4 or or CC cord-023095-4dannjjm 425 5 without without IN cord-023095-4dannjjm 425 6 concurrent concurrent JJ cord-023095-4dannjjm 425 7 antiplatelet antiplatelet NN cord-023095-4dannjjm 425 8 therapy therapy NN cord-023095-4dannjjm 425 9 , , , cord-023095-4dannjjm 425 10 is be VBZ cord-023095-4dannjjm 425 11 an an DT cord-023095-4dannjjm 425 12 effective effective JJ cord-023095-4dannjjm 425 13 antithrombotic antithrombotic JJ cord-023095-4dannjjm 425 14 treatment treatment NN cord-023095-4dannjjm 425 15 strategy strategy NN cord-023095-4dannjjm 425 16 for for IN cord-023095-4dannjjm 425 17 dogs dog NNS cord-023095-4dannjjm 425 18 with with IN cord-023095-4dannjjm 425 19 ATE ate NN cord-023095-4dannjjm 425 20 . . . cord-023095-4dannjjm 426 1 information information NN cord-023095-4dannjjm 426 2 is be VBZ cord-023095-4dannjjm 426 3 known know VBN cord-023095-4dannjjm 426 4 . . . cord-023095-4dannjjm 427 1 Through through IN cord-023095-4dannjjm 427 2 previous previous JJ cord-023095-4dannjjm 427 3 work work NN cord-023095-4dannjjm 427 4 , , , cord-023095-4dannjjm 427 5 investigators investigator NNS cord-023095-4dannjjm 427 6 have have VBP cord-023095-4dannjjm 427 7 encountered encounter VBN cord-023095-4dannjjm 427 8 Norfolk Norfolk NNP cord-023095-4dannjjm 427 9 Terriers Terriers NNP cord-023095-4dannjjm 427 10 ( ( -LRB- cord-023095-4dannjjm 427 11 NT NT NNP cord-023095-4dannjjm 427 12 ) ) -RRB- cord-023095-4dannjjm 427 13 with with IN cord-023095-4dannjjm 427 14 echocardiographically echocardiographically RB cord-023095-4dannjjm 427 15 apparent apparent JJ cord-023095-4dannjjm 427 16 DMVD DMVD NNS cord-023095-4dannjjm 427 17 in in IN cord-023095-4dannjjm 427 18 the the DT cord-023095-4dannjjm 427 19 absence absence NN cord-023095-4dannjjm 427 20 of of IN cord-023095-4dannjjm 427 21 a a DT cord-023095-4dannjjm 427 22 heart heart NN cord-023095-4dannjjm 427 23 murmur murmur NN cord-023095-4dannjjm 427 24 . . . cord-023095-4dannjjm 428 1 In in IN cord-023095-4dannjjm 428 2 order order NN cord-023095-4dannjjm 428 3 to to TO cord-023095-4dannjjm 428 4 more more RBR cord-023095-4dannjjm 428 5 fully fully RB cord-023095-4dannjjm 428 6 understand understand VB cord-023095-4dannjjm 428 7 DMVD DMVD NNS cord-023095-4dannjjm 428 8 in in IN cord-023095-4dannjjm 428 9 this this DT cord-023095-4dannjjm 428 10 breed breed NN cord-023095-4dannjjm 428 11 of of IN cord-023095-4dannjjm 428 12 dog dog NN cord-023095-4dannjjm 428 13 , , , cord-023095-4dannjjm 428 14 we -PRON- PRP cord-023095-4dannjjm 428 15 sought seek VBD cord-023095-4dannjjm 428 16 to to TO cord-023095-4dannjjm 428 17 characterize characterize VB cord-023095-4dannjjm 428 18 findings finding NNS cord-023095-4dannjjm 428 19 from from IN cord-023095-4dannjjm 428 20 the the DT cord-023095-4dannjjm 428 21 physical physical JJ cord-023095-4dannjjm 428 22 and and CC cord-023095-4dannjjm 428 23 echocardiographic echocardiographic JJ cord-023095-4dannjjm 428 24 exam exam NN cord-023095-4dannjjm 428 25 , , , cord-023095-4dannjjm 428 26 biochemical biochemical JJ cord-023095-4dannjjm 428 27 , , , cord-023095-4dannjjm 428 28 biomarker biomarker NN cord-023095-4dannjjm 428 29 , , , cord-023095-4dannjjm 428 30 and and CC cord-023095-4dannjjm 428 31 nutritional nutritional JJ cord-023095-4dannjjm 428 32 profile profile NN cord-023095-4dannjjm 428 33 , , , cord-023095-4dannjjm 428 34 and and CC cord-023095-4dannjjm 428 35 select select VB cord-023095-4dannjjm 428 36 environmental environmental JJ cord-023095-4dannjjm 428 37 variables variable NNS cord-023095-4dannjjm 428 38 from from IN cord-023095-4dannjjm 428 39 a a DT cord-023095-4dannjjm 428 40 cohort cohort NN cord-023095-4dannjjm 428 41 of of IN cord-023095-4dannjjm 428 42 apparently apparently RB cord-023095-4dannjjm 428 43 healthy healthy JJ cord-023095-4dannjjm 428 44 NT NT NNP cord-023095-4dannjjm 428 45 . . . cord-023095-4dannjjm 429 1 Overtly overtly RB cord-023095-4dannjjm 429 2 healthy healthy JJ cord-023095-4dannjjm 429 3 NT NT NNP cord-023095-4dannjjm 429 4 ! ! . cord-023095-4dannjjm 430 1 6yrs 6yrs CD cord-023095-4dannjjm 430 2 old old JJ cord-023095-4dannjjm 430 3 were be VBD cord-023095-4dannjjm 430 4 recruited recruit VBN cord-023095-4dannjjm 430 5 by by IN cord-023095-4dannjjm 430 6 3 3 CD cord-023095-4dannjjm 430 7 different different JJ cord-023095-4dannjjm 430 8 veterinary veterinary JJ cord-023095-4dannjjm 430 9 hospitals hospital NNS cord-023095-4dannjjm 430 10 and and CC cord-023095-4dannjjm 430 11 underwent undergo VBD cord-023095-4dannjjm 430 12 historical historical JJ cord-023095-4dannjjm 430 13 , , , cord-023095-4dannjjm 430 14 physical physical JJ cord-023095-4dannjjm 430 15 , , , cord-023095-4dannjjm 430 16 ECG ECG NNP cord-023095-4dannjjm 430 17 , , , cord-023095-4dannjjm 430 18 and and CC cord-023095-4dannjjm 430 19 2D 2d NN cord-023095-4dannjjm 430 20 / / SYM cord-023095-4dannjjm 430 21 color color NN cord-023095-4dannjjm 430 22 - - HYPH cord-023095-4dannjjm 430 23 flow flow NN cord-023095-4dannjjm 430 24 Doppler Doppler NNP cord-023095-4dannjjm 430 25 echocardiographic echocardiographic JJ cord-023095-4dannjjm 430 26 exam exam NN cord-023095-4dannjjm 430 27 . . . cord-023095-4dannjjm 431 1 Anterior anterior JJ cord-023095-4dannjjm 431 2 mitral mitral JJ cord-023095-4dannjjm 431 3 valve valve NN cord-023095-4dannjjm 431 4 length length NN cord-023095-4dannjjm 431 5 , , , cord-023095-4dannjjm 431 6 maximal maximal JJ cord-023095-4dannjjm 431 7 thickness thickness NN cord-023095-4dannjjm 431 8 , , , cord-023095-4dannjjm 431 9 area area NN cord-023095-4dannjjm 431 10 , , , cord-023095-4dannjjm 431 11 and and CC cord-023095-4dannjjm 431 12 prolapse prolapse NN cord-023095-4dannjjm 431 13 were be VBD cord-023095-4dannjjm 431 14 measured measure VBN cord-023095-4dannjjm 431 15 from from IN cord-023095-4dannjjm 431 16 2D 2d NN cord-023095-4dannjjm 431 17 images image NNS cord-023095-4dannjjm 431 18 . . . cord-023095-4dannjjm 432 1 Presence presence NN cord-023095-4dannjjm 432 2 of of IN cord-023095-4dannjjm 432 3 DMVD DMVD NNP cord-023095-4dannjjm 432 4 was be VBD cord-023095-4dannjjm 432 5 defined define VBN cord-023095-4dannjjm 432 6 as as IN cord-023095-4dannjjm 432 7 thickened thicken VBN cord-023095-4dannjjm 432 8 , , , cord-023095-4dannjjm 432 9 prolapsing prolapsing NN cord-023095-4dannjjm 432 10 , , , cord-023095-4dannjjm 432 11 or or CC cord-023095-4dannjjm 432 12 flail flail VB cord-023095-4dannjjm 432 13 mitral mitral JJ cord-023095-4dannjjm 432 14 valve valve NN cord-023095-4dannjjm 432 15 leaflets leaflet NNS cord-023095-4dannjjm 432 16 in in IN cord-023095-4dannjjm 432 17 the the DT cord-023095-4dannjjm 432 18 presence presence NN cord-023095-4dannjjm 432 19 of of IN cord-023095-4dannjjm 432 20 color color NN cord-023095-4dannjjm 432 21 flow flow NN cord-023095-4dannjjm 432 22 Doppler Doppler NNP cord-023095-4dannjjm 432 23 evidence evidence NN cord-023095-4dannjjm 432 24 of of IN cord-023095-4dannjjm 432 25 mitral mitral JJ cord-023095-4dannjjm 432 26 regurgitation regurgitation NN cord-023095-4dannjjm 432 27 . . . cord-023095-4dannjjm 433 1 Blood blood NN cord-023095-4dannjjm 433 2 samples sample NNS cord-023095-4dannjjm 433 3 were be VBD cord-023095-4dannjjm 433 4 obtained obtain VBN cord-023095-4dannjjm 433 5 for for IN cord-023095-4dannjjm 433 6 serum serum NN cord-023095-4dannjjm 433 7 biochemistry biochemistry NN cord-023095-4dannjjm 433 8 and and CC cord-023095-4dannjjm 433 9 serotonin serotonin NN cord-023095-4dannjjm 433 10 , , , cord-023095-4dannjjm 433 11 plasma plasma NN cord-023095-4dannjjm 433 12 NT nt NN cord-023095-4dannjjm 433 13 - - HYPH cord-023095-4dannjjm 433 14 proBNP probnp NN cord-023095-4dannjjm 433 15 , , , cord-023095-4dannjjm 433 16 amino amino NN cord-023095-4dannjjm 433 17 acid acid NN cord-023095-4dannjjm 433 18 profile profile NN cord-023095-4dannjjm 433 19 , , , cord-023095-4dannjjm 433 20 C c NN cord-023095-4dannjjm 433 21 - - HYPH cord-023095-4dannjjm 433 22 reactive reactive JJ cord-023095-4dannjjm 433 23 protein protein NN cord-023095-4dannjjm 433 24 , , , cord-023095-4dannjjm 433 25 and and CC cord-023095-4dannjjm 433 26 cardiac cardiac JJ cord-023095-4dannjjm 433 27 troponin troponin JJ cord-023095-4dannjjm 433 28 - - HYPH cord-023095-4dannjjm 433 29 I. I. NNP cord-023095-4dannjjm 433 30 Forty Forty NNP cord-023095-4dannjjm 433 31 - - HYPH cord-023095-4dannjjm 433 32 eight eight CD cord-023095-4dannjjm 433 33 dogs dog NNS cord-023095-4dannjjm 433 34 were be VBD cord-023095-4dannjjm 433 35 entered enter VBN cord-023095-4dannjjm 433 36 into into IN cord-023095-4dannjjm 433 37 the the DT cord-023095-4dannjjm 433 38 study study NN cord-023095-4dannjjm 433 39 ( ( -LRB- cord-023095-4dannjjm 433 40 median median JJ cord-023095-4dannjjm 433 41 age age NN cord-023095-4dannjjm 433 42 , , , cord-023095-4dannjjm 433 43 8yrs 8yrs NNP cord-023095-4dannjjm 433 44 IQR IQR NNP cord-023095-4dannjjm 433 45 [ [ -LRB- cord-023095-4dannjjm 433 46 7 7 CD cord-023095-4dannjjm 433 47 - - SYM cord-023095-4dannjjm 433 48 10 10 CD cord-023095-4dannjjm 433 49 ] ] -RRB- cord-023095-4dannjjm 433 50 ; ; : cord-023095-4dannjjm 433 51 gender gender NN cord-023095-4dannjjm 433 52 , , , cord-023095-4dannjjm 433 53 29F 29f CD cord-023095-4dannjjm 433 54 , , , cord-023095-4dannjjm 433 55 19 19 CD cord-023095-4dannjjm 433 56 M M NNP cord-023095-4dannjjm 433 57 ; ; : cord-023095-4dannjjm 433 58 median median JJ cord-023095-4dannjjm 433 59 BCS BCS NNP cord-023095-4dannjjm 433 60 , , , cord-023095-4dannjjm 433 61 ) ) -RRB- cord-023095-4dannjjm 433 62 . . . cord-023095-4dannjjm 434 1 Of of IN cord-023095-4dannjjm 434 2 the the DT cord-023095-4dannjjm 434 3 48 48 CD cord-023095-4dannjjm 434 4 dogs dog NNS cord-023095-4dannjjm 434 5 , , , cord-023095-4dannjjm 434 6 23 23 CD cord-023095-4dannjjm 434 7 ( ( -LRB- cord-023095-4dannjjm 434 8 48 48 CD cord-023095-4dannjjm 434 9 % % NN cord-023095-4dannjjm 434 10 ) ) -RRB- cord-023095-4dannjjm 434 11 had have VBD cord-023095-4dannjjm 434 12 murmurs murmur NNS cord-023095-4dannjjm 434 13 , , , cord-023095-4dannjjm 434 14 2 2 CD cord-023095-4dannjjm 434 15 ( ( -LRB- cord-023095-4dannjjm 434 16 4 4 CD cord-023095-4dannjjm 434 17 % % NN cord-023095-4dannjjm 434 18 ) ) -RRB- cord-023095-4dannjjm 434 19 had have VBD cord-023095-4dannjjm 434 20 mid mid JJ cord-023095-4dannjjm 434 21 - - JJ cord-023095-4dannjjm 434 22 systolic systolic JJ cord-023095-4dannjjm 434 23 clicks click NNS cord-023095-4dannjjm 434 24 , , , cord-023095-4dannjjm 434 25 11 11 CD cord-023095-4dannjjm 434 26 ( ( -LRB- cord-023095-4dannjjm 434 27 23 23 CD cord-023095-4dannjjm 434 28 % % NN cord-023095-4dannjjm 434 29 ) ) -RRB- cord-023095-4dannjjm 434 30 had have VBD cord-023095-4dannjjm 434 31 ECG ECG NNP cord-023095-4dannjjm 434 32 p p NN cord-023095-4dannjjm 434 33 - - HYPH cord-023095-4dannjjm 434 34 pulmonale pulmonale NN cord-023095-4dannjjm 434 35 , , , cord-023095-4dannjjm 434 36 and and CC cord-023095-4dannjjm 434 37 41 41 CD cord-023095-4dannjjm 434 38 ( ( -LRB- cord-023095-4dannjjm 434 39 85 85 CD cord-023095-4dannjjm 434 40 % % NN cord-023095-4dannjjm 434 41 ) ) -RRB- cord-023095-4dannjjm 434 42 were be VBD cord-023095-4dannjjm 434 43 deemed deem VBN cord-023095-4dannjjm 434 44 to to TO cord-023095-4dannjjm 434 45 have have VB cord-023095-4dannjjm 434 46 echocardiographic echocardiographic JJ cord-023095-4dannjjm 434 47 evidence evidence NN cord-023095-4dannjjm 434 48 of of IN cord-023095-4dannjjm 434 49 DMVD DMVD NNP cord-023095-4dannjjm 434 50 , , , cord-023095-4dannjjm 434 51 including include VBG cord-023095-4dannjjm 434 52 18 18 CD cord-023095-4dannjjm 434 53 NT NT NNP cord-023095-4dannjjm 434 54 without without IN cord-023095-4dannjjm 434 55 a a DT cord-023095-4dannjjm 434 56 murmur murmur NN cord-023095-4dannjjm 434 57 . . . cord-023095-4dannjjm 435 1 Seven seven CD cord-023095-4dannjjm 435 2 ( ( -LRB- cord-023095-4dannjjm 435 3 15 15 CD cord-023095-4dannjjm 435 4 % % NN cord-023095-4dannjjm 435 5 ) ) -RRB- cord-023095-4dannjjm 435 6 , , , cord-023095-4dannjjm 435 7 28 28 CD cord-023095-4dannjjm 435 8 ( ( -LRB- cord-023095-4dannjjm 435 9 58 58 CD cord-023095-4dannjjm 435 10 % % NN cord-023095-4dannjjm 435 11 ) ) -RRB- cord-023095-4dannjjm 435 12 , , , cord-023095-4dannjjm 435 13 and and CC cord-023095-4dannjjm 435 14 13 13 CD cord-023095-4dannjjm 435 15 ( ( -LRB- cord-023095-4dannjjm 435 16 27 27 CD cord-023095-4dannjjm 435 17 % % NN cord-023095-4dannjjm 435 18 ) ) -RRB- cord-023095-4dannjjm 435 19 dogs dog NNS cord-023095-4dannjjm 435 20 were be VBD cord-023095-4dannjjm 435 21 classified classify VBN cord-023095-4dannjjm 435 22 as as IN cord-023095-4dannjjm 435 23 ISACHC ISACHC NNP cord-023095-4dannjjm 435 24 0 0 NFP cord-023095-4dannjjm 435 25 , , , cord-023095-4dannjjm 435 26 1a 1a CD cord-023095-4dannjjm 435 27 , , , cord-023095-4dannjjm 435 28 and and CC cord-023095-4dannjjm 435 29 1b 1b CD cord-023095-4dannjjm 435 30 , , , cord-023095-4dannjjm 435 31 respectively respectively RB cord-023095-4dannjjm 435 32 . . . cord-023095-4dannjjm 436 1 Mean mean JJ cord-023095-4dannjjm 436 2 indexed index VBN cord-023095-4dannjjm 436 3 echocardiographic echocardiographic JJ cord-023095-4dannjjm 436 4 mitral mitral JJ cord-023095-4dannjjm 436 5 leaflet leaflet NN cord-023095-4dannjjm 436 6 length length NN cord-023095-4dannjjm 436 7 ( ( -LRB- cord-023095-4dannjjm 436 8 P p NN cord-023095-4dannjjm 436 9 o o NN cord-023095-4dannjjm 436 10 0.0001 0.0001 CD cord-023095-4dannjjm 436 11 ) ) -RRB- cord-023095-4dannjjm 436 12 , , , cord-023095-4dannjjm 436 13 thickness thickness NN cord-023095-4dannjjm 436 14 ( ( -LRB- cord-023095-4dannjjm 436 15 P p NN cord-023095-4dannjjm 436 16 5 5 CD cord-023095-4dannjjm 436 17 0.019 0.019 CD cord-023095-4dannjjm 436 18 ) ) -RRB- cord-023095-4dannjjm 436 19 , , , cord-023095-4dannjjm 436 20 prolapse prolapse NN cord-023095-4dannjjm 436 21 ( ( -LRB- cord-023095-4dannjjm 436 22 P p NN cord-023095-4dannjjm 436 23 5 5 CD cord-023095-4dannjjm 436 24 0.0005 0.0005 CD cord-023095-4dannjjm 436 25 ) ) -RRB- cord-023095-4dannjjm 436 26 , , , cord-023095-4dannjjm 436 27 and and CC cord-023095-4dannjjm 436 28 LA la NN cord-023095-4dannjjm 436 29 : : : cord-023095-4dannjjm 436 30 AoD AoD NNP cord-023095-4dannjjm 436 31 ( ( -LRB- cord-023095-4dannjjm 436 32 P p NN cord-023095-4dannjjm 436 33 5 5 CD cord-023095-4dannjjm 436 34 0.01 0.01 CD cord-023095-4dannjjm 436 35 ) ) -RRB- cord-023095-4dannjjm 436 36 were be VBD cord-023095-4dannjjm 436 37 significantly significantly RB cord-023095-4dannjjm 436 38 different different JJ cord-023095-4dannjjm 436 39 between between IN cord-023095-4dannjjm 436 40 ISACHC ISACHC NNP cord-023095-4dannjjm 436 41 1a 1a NNP cord-023095-4dannjjm 436 42 / / SYM cord-023095-4dannjjm 436 43 b b NN cord-023095-4dannjjm 436 44 vs vs IN cord-023095-4dannjjm 436 45 0 0 CD cord-023095-4dannjjm 436 46 . . . cord-023095-4dannjjm 437 1 Between between IN cord-023095-4dannjjm 437 2 ISACHC ISACHC NNP cord-023095-4dannjjm 437 3 1a/1b 1a/1b CD cord-023095-4dannjjm 437 4 and and CC cord-023095-4dannjjm 437 5 0 0 CD cord-023095-4dannjjm 437 6 , , , cord-023095-4dannjjm 437 7 there there EX cord-023095-4dannjjm 437 8 were be VBD cord-023095-4dannjjm 437 9 no no DT cord-023095-4dannjjm 437 10 differences difference NNS cord-023095-4dannjjm 437 11 in in IN cord-023095-4dannjjm 437 12 serum serum NN cord-023095-4dannjjm 437 13 amino amino NN cord-023095-4dannjjm 437 14 acids acid NNS cord-023095-4dannjjm 437 15 , , , cord-023095-4dannjjm 437 16 C c NN cord-023095-4dannjjm 437 17 - - HYPH cord-023095-4dannjjm 437 18 reactive reactive JJ cord-023095-4dannjjm 437 19 protein protein NN cord-023095-4dannjjm 437 20 , , , cord-023095-4dannjjm 437 21 troponin troponin JJ cord-023095-4dannjjm 437 22 , , , cord-023095-4dannjjm 437 23 diet diet NN cord-023095-4dannjjm 437 24 , , , cord-023095-4dannjjm 437 25 or or CC cord-023095-4dannjjm 437 26 environmental environmental JJ cord-023095-4dannjjm 437 27 factors factor NNS cord-023095-4dannjjm 437 28 ; ; : cord-023095-4dannjjm 437 29 however however RB cord-023095-4dannjjm 437 30 6 6 CD cord-023095-4dannjjm 437 31 different different JJ cord-023095-4dannjjm 437 32 amino amino NN cord-023095-4dannjjm 437 33 acids acid NNS cord-023095-4dannjjm 437 34 ( ( -LRB- cord-023095-4dannjjm 437 35 Ala Ala NNP cord-023095-4dannjjm 437 36 , , , cord-023095-4dannjjm 437 37 Gly Gly NNP cord-023095-4dannjjm 437 38 , , , cord-023095-4dannjjm 437 39 Phe Phe NNP cord-023095-4dannjjm 437 40 , , , cord-023095-4dannjjm 437 41 Pro Pro NNP cord-023095-4dannjjm 437 42 , , , cord-023095-4dannjjm 437 43 Trp Trp NNP cord-023095-4dannjjm 437 44 , , , cord-023095-4dannjjm 437 45 Tyr Tyr NNP cord-023095-4dannjjm 437 46 ) ) -RRB- cord-023095-4dannjjm 437 47 were be VBD cord-023095-4dannjjm 437 48 significantly significantly RB cord-023095-4dannjjm 437 49 higher high JJR cord-023095-4dannjjm 437 50 in in IN cord-023095-4dannjjm 437 51 ISACHC ISACHC NNP cord-023095-4dannjjm 437 52 1b 1b CD cord-023095-4dannjjm 437 53 vs. vs. FW cord-023095-4dannjjm 437 54 1a 1a CD cord-023095-4dannjjm 437 55 . . . cord-023095-4dannjjm 438 1 Median median JJ cord-023095-4dannjjm 438 2 serum serum NN cord-023095-4dannjjm 438 3 serotonin serotonin NN cord-023095-4dannjjm 438 4 was be VBD cord-023095-4dannjjm 438 5 increased increase VBN cord-023095-4dannjjm 438 6 in in IN cord-023095-4dannjjm 438 7 dogs dog NNS cord-023095-4dannjjm 438 8 with with IN cord-023095-4dannjjm 438 9 1a 1a CD cord-023095-4dannjjm 438 10 / / SYM cord-023095-4dannjjm 438 11 b b NN cord-023095-4dannjjm 438 12 vs. vs. NN cord-023095-4dannjjm 438 13 0 0 NFP cord-023095-4dannjjm 439 1 ( ( -LRB- cord-023095-4dannjjm 439 2 P p NN cord-023095-4dannjjm 439 3 5 5 CD cord-023095-4dannjjm 439 4 0.025 0.025 CD cord-023095-4dannjjm 439 5 ) ) -RRB- cord-023095-4dannjjm 439 6 . . . cord-023095-4dannjjm 440 1 Dogs dog NNS cord-023095-4dannjjm 440 2 whose whose WP$ cord-023095-4dannjjm 440 3 diets diet NNS cord-023095-4dannjjm 440 4 contained contain VBD cord-023095-4dannjjm 440 5 some some DT cord-023095-4dannjjm 440 6 canned can VBN cord-023095-4dannjjm 440 7 food food NN cord-023095-4dannjjm 440 8 ( ( -LRB- cord-023095-4dannjjm 440 9 P p NN cord-023095-4dannjjm 440 10 5 5 CD cord-023095-4dannjjm 440 11 0.12 0.12 CD cord-023095-4dannjjm 440 12 ) ) -RRB- cord-023095-4dannjjm 440 13 and and CC cord-023095-4dannjjm 440 14 dogs dog NNS cord-023095-4dannjjm 440 15 residing reside VBG cord-023095-4dannjjm 440 16 in in IN cord-023095-4dannjjm 440 17 suburban suburban JJ cord-023095-4dannjjm 440 18 environments environment NNS cord-023095-4dannjjm 440 19 ( ( -LRB- cord-023095-4dannjjm 440 20 P p NN cord-023095-4dannjjm 440 21 5 5 CD cord-023095-4dannjjm 440 22 0.03 0.03 CD cord-023095-4dannjjm 440 23 ) ) -RRB- cord-023095-4dannjjm 440 24 had have VBD cord-023095-4dannjjm 440 25 higher high JJR cord-023095-4dannjjm 440 26 serotonin serotonin NN cord-023095-4dannjjm 440 27 concentrations concentration NNS cord-023095-4dannjjm 440 28 . . . cord-023095-4dannjjm 441 1 NT NT NNP cord-023095-4dannjjm 441 2 - - HYPH cord-023095-4dannjjm 441 3 proBNP proBNP NNP cord-023095-4dannjjm 441 4 tended tend VBD cord-023095-4dannjjm 441 5 ( ( -LRB- cord-023095-4dannjjm 441 6 P p NN cord-023095-4dannjjm 441 7 5 5 CD cord-023095-4dannjjm 441 8 0.07 0.07 CD cord-023095-4dannjjm 441 9 ) ) -RRB- cord-023095-4dannjjm 441 10 to to TO cord-023095-4dannjjm 441 11 be be VB cord-023095-4dannjjm 441 12 higher high JJR cord-023095-4dannjjm 441 13 in in IN cord-023095-4dannjjm 441 14 ISACHC ISACHC NNP cord-023095-4dannjjm 441 15 1a/1b 1a/1b CD cord-023095-4dannjjm 441 16 vs. vs. IN cord-023095-4dannjjm 441 17 0 0 CD cord-023095-4dannjjm 441 18 . . . cord-023095-4dannjjm 442 1 DMVD DMVD NNP cord-023095-4dannjjm 442 2 appears appear VBZ cord-023095-4dannjjm 442 3 to to TO cord-023095-4dannjjm 442 4 be be VB cord-023095-4dannjjm 442 5 relatively relatively RB cord-023095-4dannjjm 442 6 common common JJ cord-023095-4dannjjm 442 7 in in IN cord-023095-4dannjjm 442 8 NT NT NNP cord-023095-4dannjjm 442 9 and and CC cord-023095-4dannjjm 442 10 echocardiographic echocardiographic JJ cord-023095-4dannjjm 442 11 changes change VBZ cord-023095-4dannjjm 442 12 consistent consistent JJ cord-023095-4dannjjm 442 13 with with IN cord-023095-4dannjjm 442 14 mild mild JJ cord-023095-4dannjjm 442 15 DMVD DMVD NNS cord-023095-4dannjjm 442 16 can can MD cord-023095-4dannjjm 442 17 be be VB cord-023095-4dannjjm 442 18 seen see VBN cord-023095-4dannjjm 442 19 in in IN cord-023095-4dannjjm 442 20 dogs dog NNS cord-023095-4dannjjm 442 21 without without IN cord-023095-4dannjjm 442 22 a a DT cord-023095-4dannjjm 442 23 heart heart NN cord-023095-4dannjjm 442 24 murmur murmur NN cord-023095-4dannjjm 442 25 . . . cord-023095-4dannjjm 443 1 The the DT cord-023095-4dannjjm 443 2 results result NNS cord-023095-4dannjjm 443 3 of of IN cord-023095-4dannjjm 443 4 this this DT cord-023095-4dannjjm 443 5 study study NN cord-023095-4dannjjm 443 6 establish establish VB cord-023095-4dannjjm 443 7 a a DT cord-023095-4dannjjm 443 8 foundation foundation NN cord-023095-4dannjjm 443 9 of of IN cord-023095-4dannjjm 443 10 useful useful JJ cord-023095-4dannjjm 443 11 information information NN cord-023095-4dannjjm 443 12 upon upon IN cord-023095-4dannjjm 443 13 which which WDT cord-023095-4dannjjm 443 14 additional additional JJ cord-023095-4dannjjm 443 15 prospective prospective JJ cord-023095-4dannjjm 443 16 studies study NNS cord-023095-4dannjjm 443 17 can can MD cord-023095-4dannjjm 443 18 be be VB cord-023095-4dannjjm 443 19 developed develop VBN cord-023095-4dannjjm 443 20 . . . cord-023095-4dannjjm 444 1 Left left JJ cord-023095-4dannjjm 444 2 ventricle ventricle NN cord-023095-4dannjjm 444 3 ( ( -LRB- cord-023095-4dannjjm 444 4 LV LV NNP cord-023095-4dannjjm 444 5 ) ) -RRB- cord-023095-4dannjjm 444 6 evaluation evaluation NN cord-023095-4dannjjm 444 7 is be VBZ cord-023095-4dannjjm 444 8 one one CD cord-023095-4dannjjm 444 9 of of IN cord-023095-4dannjjm 444 10 the the DT cord-023095-4dannjjm 444 11 most most RBS cord-023095-4dannjjm 444 12 important important JJ cord-023095-4dannjjm 444 13 contributions contribution NNS cord-023095-4dannjjm 444 14 of of IN cord-023095-4dannjjm 444 15 echocardiography echocardiography NN cord-023095-4dannjjm 444 16 in in IN cord-023095-4dannjjm 444 17 the the DT cord-023095-4dannjjm 444 18 assessment assessment NN cord-023095-4dannjjm 444 19 of of IN cord-023095-4dannjjm 444 20 cardiac cardiac JJ cord-023095-4dannjjm 444 21 function function NN cord-023095-4dannjjm 444 22 . . . cord-023095-4dannjjm 445 1 However however RB cord-023095-4dannjjm 445 2 , , , cord-023095-4dannjjm 445 3 LV LV NNP cord-023095-4dannjjm 445 4 analysis analysis NN cord-023095-4dannjjm 445 5 can can MD cord-023095-4dannjjm 445 6 be be VB cord-023095-4dannjjm 445 7 made make VBN cord-023095-4dannjjm 445 8 from from IN cord-023095-4dannjjm 445 9 images image NNS cord-023095-4dannjjm 445 10 obtained obtain VBN cord-023095-4dannjjm 445 11 by by IN cord-023095-4dannjjm 445 12 different different JJ cord-023095-4dannjjm 445 13 modes mode NNS cord-023095-4dannjjm 445 14 and and CC cord-023095-4dannjjm 445 15 views view NNS cord-023095-4dannjjm 445 16 of of IN cord-023095-4dannjjm 445 17 the the DT cord-023095-4dannjjm 445 18 heart heart NN cord-023095-4dannjjm 445 19 . . . cord-023095-4dannjjm 446 1 The the DT cord-023095-4dannjjm 446 2 aim aim NN cord-023095-4dannjjm 446 3 of of IN cord-023095-4dannjjm 446 4 this this DT cord-023095-4dannjjm 446 5 study study NN cord-023095-4dannjjm 446 6 was be VBD cord-023095-4dannjjm 446 7 to to TO cord-023095-4dannjjm 446 8 compare compare VB cord-023095-4dannjjm 446 9 LV LV NNP cord-023095-4dannjjm 446 10 measurements measurement NNS cord-023095-4dannjjm 446 11 , , , cord-023095-4dannjjm 446 12 shortening shorten VBG cord-023095-4dannjjm 446 13 fraction fraction NN cord-023095-4dannjjm 446 14 ( ( -LRB- cord-023095-4dannjjm 446 15 SF SF NNP cord-023095-4dannjjm 446 16 ) ) -RRB- cord-023095-4dannjjm 446 17 and and CC cord-023095-4dannjjm 446 18 ejection ejection NN cord-023095-4dannjjm 446 19 fraction fraction NN cord-023095-4dannjjm 446 20 ( ( -LRB- cord-023095-4dannjjm 446 21 EF EF NNP cord-023095-4dannjjm 446 22 ) ) -RRB- cord-023095-4dannjjm 446 23 obtained obtain VBD cord-023095-4dannjjm 446 24 from from IN cord-023095-4dannjjm 446 25 four four CD cord-023095-4dannjjm 446 26 methods method NNS cord-023095-4dannjjm 446 27 : : : cord-023095-4dannjjm 446 28 M m NN cord-023095-4dannjjm 446 29 mode mode NN cord-023095-4dannjjm 446 30 in in IN cord-023095-4dannjjm 446 31 short short JJ cord-023095-4dannjjm 446 32 - - HYPH cord-023095-4dannjjm 446 33 axis axis NN cord-023095-4dannjjm 446 34 and and CC cord-023095-4dannjjm 446 35 in in IN cord-023095-4dannjjm 446 36 long long JJ cord-023095-4dannjjm 446 37 - - HYPH cord-023095-4dannjjm 446 38 axis axis NN cord-023095-4dannjjm 446 39 , , , cord-023095-4dannjjm 446 40 bidimensional bidimensional FW cord-023095-4dannjjm 446 41 mode mode NN cord-023095-4dannjjm 446 42 in in IN cord-023095-4dannjjm 446 43 short short JJ cord-023095-4dannjjm 446 44 - - HYPH cord-023095-4dannjjm 446 45 axis axis NN cord-023095-4dannjjm 446 46 and and CC cord-023095-4dannjjm 446 47 in in IN cord-023095-4dannjjm 446 48 long long JJ cord-023095-4dannjjm 446 49 - - HYPH cord-023095-4dannjjm 446 50 axis axis NN cord-023095-4dannjjm 446 51 views view NNS cord-023095-4dannjjm 446 52 of of IN cord-023095-4dannjjm 446 53 the the DT cord-023095-4dannjjm 446 54 heart heart NN cord-023095-4dannjjm 446 55 . . . cord-023095-4dannjjm 447 1 Forty forty CD cord-023095-4dannjjm 447 2 normal normal JJ cord-023095-4dannjjm 447 3 adult adult NN cord-023095-4dannjjm 447 4 German german JJ cord-023095-4dannjjm 447 5 Shepherds Shepherds NNPS cord-023095-4dannjjm 447 6 were be VBD cord-023095-4dannjjm 447 7 selected select VBN cord-023095-4dannjjm 447 8 . . . cord-023095-4dannjjm 448 1 Echocardiographic echocardiographic JJ cord-023095-4dannjjm 448 2 study study NN cord-023095-4dannjjm 448 3 of of IN cord-023095-4dannjjm 448 4 LV LV NNP cord-023095-4dannjjm 448 5 of of IN cord-023095-4dannjjm 448 6 each each DT cord-023095-4dannjjm 448 7 animal animal NN cord-023095-4dannjjm 448 8 was be VBD cord-023095-4dannjjm 448 9 performed perform VBN cord-023095-4dannjjm 448 10 by by IN cord-023095-4dannjjm 448 11 the the DT cord-023095-4dannjjm 448 12 four four CD cord-023095-4dannjjm 448 13 methods method NNS cord-023095-4dannjjm 448 14 described describe VBN cord-023095-4dannjjm 448 15 above above RB cord-023095-4dannjjm 448 16 . . . cord-023095-4dannjjm 449 1 ANCOVA ANCOVA NNP cord-023095-4dannjjm 449 2 test test NN cord-023095-4dannjjm 449 3 was be VBD cord-023095-4dannjjm 449 4 used use VBN cord-023095-4dannjjm 449 5 to to TO cord-023095-4dannjjm 449 6 examine examine VB cord-023095-4dannjjm 449 7 the the DT cord-023095-4dannjjm 449 8 effects effect NNS cord-023095-4dannjjm 449 9 of of IN cord-023095-4dannjjm 449 10 axis axis NN cord-023095-4dannjjm 449 11 , , , cord-023095-4dannjjm 449 12 mode mode NN cord-023095-4dannjjm 449 13 , , , cord-023095-4dannjjm 449 14 weight weight NN cord-023095-4dannjjm 449 15 and and CC cord-023095-4dannjjm 449 16 gender gender NN cord-023095-4dannjjm 449 17 over over IN cord-023095-4dannjjm 449 18 LV LV NNP cord-023095-4dannjjm 449 19 measurements measurement NNS cord-023095-4dannjjm 449 20 . . . cord-023095-4dannjjm 450 1 Isolated isolated JJ cord-023095-4dannjjm 450 2 effect effect NN cord-023095-4dannjjm 450 3 of of IN cord-023095-4dannjjm 450 4 the the DT cord-023095-4dannjjm 450 5 axis axis NN cord-023095-4dannjjm 450 6 was be VBD cord-023095-4dannjjm 450 7 observed observe VBN cord-023095-4dannjjm 450 8 for for IN cord-023095-4dannjjm 450 9 LV LV NNP cord-023095-4dannjjm 450 10 end end NN cord-023095-4dannjjm 450 11 - - HYPH cord-023095-4dannjjm 450 12 diastolic diastolic JJ cord-023095-4dannjjm 450 13 diameter diameter NN cord-023095-4dannjjm 450 14 ( ( -LRB- cord-023095-4dannjjm 450 15 LVEDD LVEDD NNP cord-023095-4dannjjm 450 16 ) ) -RRB- cord-023095-4dannjjm 450 17 , , , cord-023095-4dannjjm 450 18 with with IN cord-023095-4dannjjm 450 19 greater great JJR cord-023095-4dannjjm 450 20 values value NNS cord-023095-4dannjjm 450 21 obtained obtain VBN cord-023095-4dannjjm 450 22 from from IN cord-023095-4dannjjm 450 23 short short JJ cord-023095-4dannjjm 450 24 - - HYPH cord-023095-4dannjjm 450 25 axis axis NN cord-023095-4dannjjm 450 26 views view NNS cord-023095-4dannjjm 450 27 . . . cord-023095-4dannjjm 451 1 There there EX cord-023095-4dannjjm 451 2 was be VBD cord-023095-4dannjjm 451 3 isolated isolate VBN cord-023095-4dannjjm 451 4 effect effect NN cord-023095-4dannjjm 451 5 of of IN cord-023095-4dannjjm 451 6 mode mode NN cord-023095-4dannjjm 451 7 over over IN cord-023095-4dannjjm 451 8 EF EF NNP cord-023095-4dannjjm 451 9 and and CC cord-023095-4dannjjm 451 10 SF SF NNP cord-023095-4dannjjm 451 11 , , , cord-023095-4dannjjm 451 12 with with IN cord-023095-4dannjjm 451 13 greater great JJR cord-023095-4dannjjm 451 14 measurements measurement NNS cord-023095-4dannjjm 451 15 derived derive VBN cord-023095-4dannjjm 451 16 from from IN cord-023095-4dannjjm 451 17 bidimensional bidimensional JJ cord-023095-4dannjjm 451 18 mode mode NN cord-023095-4dannjjm 451 19 methods method NNS cord-023095-4dannjjm 451 20 . . . cord-023095-4dannjjm 452 1 Weight weight NN cord-023095-4dannjjm 452 2 correlated correlate VBD cord-023095-4dannjjm 452 3 with with IN cord-023095-4dannjjm 452 4 all all DT cord-023095-4dannjjm 452 5 linear linear JJ cord-023095-4dannjjm 452 6 LV LV NNP cord-023095-4dannjjm 452 7 measures measure NNS cord-023095-4dannjjm 452 8 at at IN cord-023095-4dannjjm 452 9 least least JJS cord-023095-4dannjjm 452 10 in in IN cord-023095-4dannjjm 452 11 one one CD cord-023095-4dannjjm 452 12 method method NN cord-023095-4dannjjm 452 13 , , , cord-023095-4dannjjm 452 14 but but CC cord-023095-4dannjjm 452 15 not not RB cord-023095-4dannjjm 452 16 with with IN cord-023095-4dannjjm 452 17 EF EF NNP cord-023095-4dannjjm 452 18 and and CC cord-023095-4dannjjm 452 19 SF SF NNP cord-023095-4dannjjm 452 20 . . . cord-023095-4dannjjm 453 1 Weight weight NN cord-023095-4dannjjm 453 2 had have VBD cord-023095-4dannjjm 453 3 positive positive JJ cord-023095-4dannjjm 453 4 effect effect NN cord-023095-4dannjjm 453 5 over over IN cord-023095-4dannjjm 453 6 LV LV NNP cord-023095-4dannjjm 453 7 endsystolic endsystolic JJ cord-023095-4dannjjm 453 8 diameter diameter NN cord-023095-4dannjjm 453 9 and and CC cord-023095-4dannjjm 453 10 LV LV NNP cord-023095-4dannjjm 453 11 end end NN cord-023095-4dannjjm 453 12 - - HYPH cord-023095-4dannjjm 453 13 diastole diastole NN cord-023095-4dannjjm 453 14 posterior posterior JJ cord-023095-4dannjjm 453 15 wall wall NN cord-023095-4dannjjm 453 16 thickness thickness NN cord-023095-4dannjjm 453 17 in in IN cord-023095-4dannjjm 453 18 all all DT cord-023095-4dannjjm 453 19 methods method NNS cord-023095-4dannjjm 453 20 , , , cord-023095-4dannjjm 453 21 except except IN cord-023095-4dannjjm 453 22 from from IN cord-023095-4dannjjm 453 23 M M NNP cord-023095-4dannjjm 453 24 mode mode NN cord-023095-4dannjjm 453 25 in in IN cord-023095-4dannjjm 453 26 short short JJ cord-023095-4dannjjm 453 27 axis axis NN cord-023095-4dannjjm 453 28 in in IN cord-023095-4dannjjm 453 29 the the DT cord-023095-4dannjjm 453 30 last last JJ cord-023095-4dannjjm 453 31 one one NN cord-023095-4dannjjm 453 32 . . . cord-023095-4dannjjm 454 1 Gender gender NN cord-023095-4dannjjm 454 2 had have VBD cord-023095-4dannjjm 454 3 isolated isolate VBN cord-023095-4dannjjm 454 4 effect effect NN cord-023095-4dannjjm 454 5 over over IN cord-023095-4dannjjm 454 6 LVEDD LVEDD NNP cord-023095-4dannjjm 454 7 , , , cord-023095-4dannjjm 454 8 males male NNS cord-023095-4dannjjm 454 9 showing show VBG cord-023095-4dannjjm 454 10 greater great JJR cord-023095-4dannjjm 454 11 values value NNS cord-023095-4dannjjm 454 12 than than IN cord-023095-4dannjjm 454 13 females female NNS cord-023095-4dannjjm 454 14 in in IN cord-023095-4dannjjm 454 15 bidimensional bidimensional JJ cord-023095-4dannjjm 454 16 mode mode NN cord-023095-4dannjjm 454 17 in in IN cord-023095-4dannjjm 454 18 short short JJ cord-023095-4dannjjm 454 19 and and CC cord-023095-4dannjjm 454 20 long long JJ cord-023095-4dannjjm 454 21 axis axis NN cord-023095-4dannjjm 454 22 . . . cord-023095-4dannjjm 455 1 The the DT cord-023095-4dannjjm 455 2 combined combined JJ cord-023095-4dannjjm 455 3 effect effect NN cord-023095-4dannjjm 455 4 of of IN cord-023095-4dannjjm 455 5 axis axis NN cord-023095-4dannjjm 455 6 , , , cord-023095-4dannjjm 455 7 gender gender NN cord-023095-4dannjjm 455 8 and and CC cord-023095-4dannjjm 455 9 weight weight NN cord-023095-4dannjjm 455 10 was be VBD cord-023095-4dannjjm 455 11 identified identify VBN cord-023095-4dannjjm 455 12 in in IN cord-023095-4dannjjm 455 13 interventricular interventricular JJ cord-023095-4dannjjm 455 14 septal septal JJ cord-023095-4dannjjm 455 15 end end NN cord-023095-4dannjjm 455 16 - - HYPH cord-023095-4dannjjm 455 17 diastolic diastolic JJ cord-023095-4dannjjm 455 18 thickness thickness NN cord-023095-4dannjjm 455 19 . . . cord-023095-4dannjjm 456 1 We -PRON- PRP cord-023095-4dannjjm 456 2 concluded conclude VBD cord-023095-4dannjjm 456 3 that that IN cord-023095-4dannjjm 456 4 normal normal JJ cord-023095-4dannjjm 456 5 reference reference NN cord-023095-4dannjjm 456 6 values value NNS cord-023095-4dannjjm 456 7 obtained obtain VBN cord-023095-4dannjjm 456 8 by by IN cord-023095-4dannjjm 456 9 different different JJ cord-023095-4dannjjm 456 10 echocardiographic echocardiographic JJ cord-023095-4dannjjm 456 11 modes mode NNS cord-023095-4dannjjm 456 12 and and CC cord-023095-4dannjjm 456 13 planes plane NNS cord-023095-4dannjjm 456 14 should should MD cord-023095-4dannjjm 456 15 not not RB cord-023095-4dannjjm 456 16 be be VB cord-023095-4dannjjm 456 17 used use VBN cord-023095-4dannjjm 456 18 interchangeably interchangeably RB cord-023095-4dannjjm 456 19 . . . cord-023095-4dannjjm 457 1 ABSTRACT ABSTRACT NNP cord-023095-4dannjjm 457 2 C-29 C-29 NNP cord-023095-4dannjjm 457 3 _SP cord-023095-4dannjjm 457 4 ASSESSMENT assessment NN cord-023095-4dannjjm 457 5 OF of IN cord-023095-4dannjjm 457 6 LEFT left JJ cord-023095-4dannjjm 457 7 VENTRICULAR ventricular JJ cord-023095-4dannjjm 457 8 DIASTOLIC diastolic JJ cord-023095-4dannjjm 457 9 FUNC func NN cord-023095-4dannjjm 457 10 - - HYPH cord-023095-4dannjjm 457 11 TION tion NN cord-023095-4dannjjm 457 12 BY by IN cord-023095-4dannjjm 457 13 COLOR color NN cord-023095-4dannjjm 457 14 TISSUE tissue NN cord-023095-4dannjjm 457 15 DOPPLER doppler NN cord-023095-4dannjjm 457 16 IMAGING imaging NN cord-023095-4dannjjm 457 17 ECHO echo NN cord-023095-4dannjjm 457 18 - - HYPH cord-023095-4dannjjm 457 19 CARDIOGRAPHY CARDIOGRAPHY NNP cord-023095-4dannjjm 457 20 IN in IN cord-023095-4dannjjm 457 21 MAINE MAINE NNP cord-023095-4dannjjm 457 22 COON COON NNP cord-023095-4dannjjm 458 1 CATS cat NNS cord-023095-4dannjjm 458 2 TESTED test VBN cord-023095-4dannjjm 458 3 FOR for IN cord-023095-4dannjjm 458 4 _SP cord-023095-4dannjjm 458 5 MYPBC MYPBC NNP cord-023095-4dannjjm 458 6 - - HYPH cord-023095-4dannjjm 458 7 AP31 AP31 NNP cord-023095-4dannjjm 458 8 MUTATION mutation NN cord-023095-4dannjjm 458 9 Hypertrophic hypertrophic JJ cord-023095-4dannjjm 458 10 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 458 11 ( ( -LRB- cord-023095-4dannjjm 458 12 HCM HCM NNP cord-023095-4dannjjm 458 13 ) ) -RRB- cord-023095-4dannjjm 458 14 , , , cord-023095-4dannjjm 458 15 characterized characterize VBN cord-023095-4dannjjm 458 16 by by IN cord-023095-4dannjjm 458 17 increased increase VBN cord-023095-4dannjjm 458 18 cardiac cardiac JJ cord-023095-4dannjjm 458 19 mass mass NN cord-023095-4dannjjm 458 20 and and CC cord-023095-4dannjjm 458 21 diastolic diastolic JJ cord-023095-4dannjjm 458 22 dysfunction dysfunction NN cord-023095-4dannjjm 458 23 , , , cord-023095-4dannjjm 458 24 is be VBZ cord-023095-4dannjjm 458 25 the the DT cord-023095-4dannjjm 458 26 most most RBS cord-023095-4dannjjm 458 27 common common JJ cord-023095-4dannjjm 458 28 feline feline JJ cord-023095-4dannjjm 458 29 heart heart NN cord-023095-4dannjjm 458 30 disease disease NN cord-023095-4dannjjm 458 31 . . . cord-023095-4dannjjm 459 1 Myocardial myocardial JJ cord-023095-4dannjjm 459 2 analysis analysis NN cord-023095-4dannjjm 459 3 by by IN cord-023095-4dannjjm 459 4 color color NN cord-023095-4dannjjm 459 5 tissue tissue NN cord-023095-4dannjjm 459 6 Doppler doppler NN cord-023095-4dannjjm 459 7 imaging imaging NN cord-023095-4dannjjm 459 8 ( ( -LRB- cord-023095-4dannjjm 459 9 TDI TDI NNP cord-023095-4dannjjm 459 10 ) ) -RRB- cord-023095-4dannjjm 459 11 is be VBZ cord-023095-4dannjjm 459 12 more more RBR cord-023095-4dannjjm 459 13 sensitive sensitive JJ cord-023095-4dannjjm 459 14 than than IN cord-023095-4dannjjm 459 15 conventional conventional JJ cord-023095-4dannjjm 459 16 echocardiography echocardiography NN cord-023095-4dannjjm 459 17 . . . cord-023095-4dannjjm 460 1 This this DT cord-023095-4dannjjm 460 2 study study NN cord-023095-4dannjjm 460 3 evaluated evaluate VBD cord-023095-4dannjjm 460 4 diastolic diastolic JJ cord-023095-4dannjjm 460 5 dysfunction dysfunction NN cord-023095-4dannjjm 460 6 in in IN cord-023095-4dannjjm 460 7 various various JJ cord-023095-4dannjjm 460 8 stages stage NNS cord-023095-4dannjjm 460 9 of of IN cord-023095-4dannjjm 460 10 feline feline JJ cord-023095-4dannjjm 460 11 HCM HCM NNP cord-023095-4dannjjm 460 12 . . . cord-023095-4dannjjm 461 1 Maine Maine NNP cord-023095-4dannjjm 461 2 Coon Coon NNP cord-023095-4dannjjm 461 3 cats cat NNS cord-023095-4dannjjm 461 4 ( ( -LRB- cord-023095-4dannjjm 461 5 n n NN cord-023095-4dannjjm 461 6 5 5 CD cord-023095-4dannjjm 461 7 57 57 CD cord-023095-4dannjjm 461 8 ) ) -RRB- cord-023095-4dannjjm 461 9 were be VBD cord-023095-4dannjjm 461 10 screened screen VBN cord-023095-4dannjjm 461 11 for for IN cord-023095-4dannjjm 461 12 the the DT cord-023095-4dannjjm 461 13 MyBPC MyBPC NNP cord-023095-4dannjjm 461 14 - - HYPH cord-023095-4dannjjm 461 15 A31P A31P NNP cord-023095-4dannjjm 461 16 mutation mutation NN cord-023095-4dannjjm 461 17 and and CC cord-023095-4dannjjm 461 18 examined examine VBD cord-023095-4dannjjm 461 19 with with IN cord-023095-4dannjjm 461 20 both both DT cord-023095-4dannjjm 461 21 echocardiography echocardiography NN cord-023095-4dannjjm 461 22 and and CC cord-023095-4dannjjm 461 23 TDI TDI NNP cord-023095-4dannjjm 461 24 . . . cord-023095-4dannjjm 462 1 Then then RB cord-023095-4dannjjm 462 2 , , , cord-023095-4dannjjm 462 3 were be VBD cord-023095-4dannjjm 462 4 phenotypically phenotypically RB cord-023095-4dannjjm 462 5 classified classify VBN cord-023095-4dannjjm 462 6 in in IN cord-023095-4dannjjm 462 7 : : : cord-023095-4dannjjm 462 8 normal normal JJ cord-023095-4dannjjm 462 9 ( ( -LRB- cord-023095-4dannjjm 462 10 n n NN cord-023095-4dannjjm 462 11 5 5 CD cord-023095-4dannjjm 462 12 45 45 CD cord-023095-4dannjjm 462 13 ) ) -RRB- cord-023095-4dannjjm 462 14 , , , cord-023095-4dannjjm 462 15 suspects suspect NNS cord-023095-4dannjjm 462 16 for for IN cord-023095-4dannjjm 462 17 HCM HCM NNP cord-023095-4dannjjm 462 18 ( ( -LRB- cord-023095-4dannjjm 462 19 n n NN cord-023095-4dannjjm 462 20 5 5 CD cord-023095-4dannjjm 462 21 7 7 CD cord-023095-4dannjjm 462 22 ) ) -RRB- cord-023095-4dannjjm 462 23 and and CC cord-023095-4dannjjm 462 24 HCM HCM NNP cord-023095-4dannjjm 462 25 group group NN cord-023095-4dannjjm 462 26 ( ( -LRB- cord-023095-4dannjjm 462 27 n n NN cord-023095-4dannjjm 462 28 5 5 CD cord-023095-4dannjjm 462 29 5 5 CD cord-023095-4dannjjm 462 30 ) ) -RRB- cord-023095-4dannjjm 462 31 ; ; : cord-023095-4dannjjm 462 32 and and CC cord-023095-4dannjjm 462 33 genotypically genotypically RB cord-023095-4dannjjm 462 34 classified classify VBN cord-023095-4dannjjm 462 35 in in IN cord-023095-4dannjjm 462 36 : : : cord-023095-4dannjjm 462 37 negative negative JJ cord-023095-4dannjjm 462 38 ( ( -LRB- cord-023095-4dannjjm 462 39 n n NN cord-023095-4dannjjm 462 40 5 5 CD cord-023095-4dannjjm 462 41 28 28 CD cord-023095-4dannjjm 462 42 ) ) -RRB- cord-023095-4dannjjm 462 43 , , , cord-023095-4dannjjm 462 44 heterozygous heterozygous JJ cord-023095-4dannjjm 462 45 ( ( -LRB- cord-023095-4dannjjm 462 46 n n NN cord-023095-4dannjjm 462 47 5 5 CD cord-023095-4dannjjm 462 48 26 26 CD cord-023095-4dannjjm 462 49 ) ) -RRB- cord-023095-4dannjjm 462 50 and and CC cord-023095-4dannjjm 462 51 homozygous homozygous JJ cord-023095-4dannjjm 462 52 group group NN cord-023095-4dannjjm 462 53 ( ( -LRB- cord-023095-4dannjjm 462 54 n n NN cord-023095-4dannjjm 462 55 5 5 CD cord-023095-4dannjjm 462 56 3 3 CD cord-023095-4dannjjm 462 57 ) ) -RRB- cord-023095-4dannjjm 462 58 . . . cord-023095-4dannjjm 463 1 Myocardial myocardial JJ cord-023095-4dannjjm 463 2 velocities velocity NNS cord-023095-4dannjjm 463 3 , , , cord-023095-4dannjjm 463 4 measured measure VBN cord-023095-4dannjjm 463 5 in in IN cord-023095-4dannjjm 463 6 the the DT cord-023095-4dannjjm 463 7 basal basal NN cord-023095-4dannjjm 463 8 and and CC cord-023095-4dannjjm 463 9 mild mild JJ cord-023095-4dannjjm 463 10 ventricular ventricular JJ cord-023095-4dannjjm 463 11 segment segment NN cord-023095-4dannjjm 463 12 of of IN cord-023095-4dannjjm 463 13 the the DT cord-023095-4dannjjm 463 14 interventricular interventricular JJ cord-023095-4dannjjm 463 15 septal septal JJ cord-023095-4dannjjm 463 16 wall wall NN cord-023095-4dannjjm 463 17 ( ( -LRB- cord-023095-4dannjjm 463 18 IVS IVS NNP cord-023095-4dannjjm 463 19 ) ) -RRB- cord-023095-4dannjjm 463 20 , , , cord-023095-4dannjjm 463 21 left leave VBD cord-023095-4dannjjm 463 22 ventricular ventricular JJ cord-023095-4dannjjm 463 23 free free JJ cord-023095-4dannjjm 463 24 wall wall NN cord-023095-4dannjjm 463 25 ( ( -LRB- cord-023095-4dannjjm 463 26 LVW LVW NNP cord-023095-4dannjjm 463 27 ) ) -RRB- cord-023095-4dannjjm 463 28 and and CC cord-023095-4dannjjm 463 29 in in IN cord-023095-4dannjjm 463 30 radial radial JJ cord-023095-4dannjjm 463 31 segment segment NN cord-023095-4dannjjm 463 32 of of IN cord-023095-4dannjjm 463 33 left left JJ cord-023095-4dannjjm 463 34 ventricular ventricular JJ cord-023095-4dannjjm 463 35 wall wall NN cord-023095-4dannjjm 463 36 , , , cord-023095-4dannjjm 463 37 was be VBD cord-023095-4dannjjm 463 38 compared compare VBN cord-023095-4dannjjm 463 39 among among IN cord-023095-4dannjjm 463 40 different different JJ cord-023095-4dannjjm 463 41 groups group NNS cord-023095-4dannjjm 463 42 . . . cord-023095-4dannjjm 464 1 A a DT cord-023095-4dannjjm 464 2 significant significant JJ cord-023095-4dannjjm 464 3 decreased decrease VBD cord-023095-4dannjjm 464 4 ( ( -LRB- cord-023095-4dannjjm 464 5 P p NN cord-023095-4dannjjm 464 6 5 5 CD cord-023095-4dannjjm 464 7 0,01 0,01 CD cord-023095-4dannjjm 464 8 ) ) -RRB- cord-023095-4dannjjm 465 1 longitudinal longitudinal NNP cord-023095-4dannjjm 465 2 Em Em NNP cord-023095-4dannjjm 465 3 / / SYM cord-023095-4dannjjm 465 4 Am be VBP cord-023095-4dannjjm 465 5 at at IN cord-023095-4dannjjm 465 6 the the DT cord-023095-4dannjjm 465 7 basal basal NN cord-023095-4dannjjm 465 8 segment segment NN cord-023095-4dannjjm 465 9 of of IN cord-023095-4dannjjm 465 10 IVS IVS NNP cord-023095-4dannjjm 465 11 was be VBD cord-023095-4dannjjm 465 12 observed observe VBN cord-023095-4dannjjm 465 13 in in IN cord-023095-4dannjjm 465 14 HCM HCM NNP cord-023095-4dannjjm 465 15 cats cat NNS cord-023095-4dannjjm 465 16 compared compare VBN cord-023095-4dannjjm 465 17 with with IN cord-023095-4dannjjm 465 18 suspects suspect NNS cord-023095-4dannjjm 465 19 and and CC cord-023095-4dannjjm 465 20 normal normal JJ cord-023095-4dannjjm 465 21 cats cat NNS cord-023095-4dannjjm 465 22 . . . cord-023095-4dannjjm 466 1 A a DT cord-023095-4dannjjm 466 2 significant significant JJ cord-023095-4dannjjm 466 3 increased increase VBN cord-023095-4dannjjm 466 4 ( ( -LRB- cord-023095-4dannjjm 466 5 P p NN cord-023095-4dannjjm 466 6 5 5 CD cord-023095-4dannjjm 466 7 0,01 0,01 CD cord-023095-4dannjjm 466 8 ) ) -RRB- cord-023095-4dannjjm 467 1 longitudinal longitudinal NNP cord-023095-4dannjjm 467 2 E E NNP cord-023095-4dannjjm 467 3 / / SYM cord-023095-4dannjjm 467 4 Em Em NNP cord-023095-4dannjjm 467 5 at at IN cord-023095-4dannjjm 467 6 the the DT cord-023095-4dannjjm 467 7 basal basal NN cord-023095-4dannjjm 467 8 segment segment NN cord-023095-4dannjjm 467 9 of of IN cord-023095-4dannjjm 467 10 IVS IVS NNP cord-023095-4dannjjm 467 11 was be VBD cord-023095-4dannjjm 467 12 observed observe VBN cord-023095-4dannjjm 467 13 in in IN cord-023095-4dannjjm 467 14 HCM HCM NNP cord-023095-4dannjjm 467 15 cats cat NNS cord-023095-4dannjjm 467 16 compared compare VBN cord-023095-4dannjjm 467 17 with with IN cord-023095-4dannjjm 467 18 suspects suspect NNS cord-023095-4dannjjm 467 19 and and CC cord-023095-4dannjjm 467 20 normal normal JJ cord-023095-4dannjjm 467 21 cats cat NNS cord-023095-4dannjjm 467 22 . . . cord-023095-4dannjjm 468 1 And and CC cord-023095-4dannjjm 468 2 a a DT cord-023095-4dannjjm 468 3 significant significant JJ cord-023095-4dannjjm 468 4 decreased decrease VBN cord-023095-4dannjjm 468 5 ( ( -LRB- cord-023095-4dannjjm 468 6 P p NN cord-023095-4dannjjm 468 7 5 5 CD cord-023095-4dannjjm 468 8 0,02 0,02 CD cord-023095-4dannjjm 468 9 ) ) -RRB- cord-023095-4dannjjm 469 1 longitudinal longitudinal NNP cord-023095-4dannjjm 469 2 Sm Sm NNP cord-023095-4dannjjm 469 3 at at IN cord-023095-4dannjjm 469 4 the the DT cord-023095-4dannjjm 469 5 basal basal NN cord-023095-4dannjjm 469 6 segment segment NN cord-023095-4dannjjm 469 7 of of IN cord-023095-4dannjjm 469 8 the the DT cord-023095-4dannjjm 469 9 LVW LVW NNP cord-023095-4dannjjm 469 10 was be VBD cord-023095-4dannjjm 469 11 observed observe VBN cord-023095-4dannjjm 469 12 in in IN cord-023095-4dannjjm 469 13 heterozygous heterozygous JJ cord-023095-4dannjjm 469 14 cats cat NNS cord-023095-4dannjjm 469 15 compared compare VBN cord-023095-4dannjjm 469 16 with with IN cord-023095-4dannjjm 469 17 negative negative JJ cord-023095-4dannjjm 469 18 cats cat NNS cord-023095-4dannjjm 469 19 , , , cord-023095-4dannjjm 469 20 both both CC cord-023095-4dannjjm 469 21 without without IN cord-023095-4dannjjm 469 22 hypertrophy hypertrophy NN cord-023095-4dannjjm 469 23 . . . cord-023095-4dannjjm 470 1 There there EX cord-023095-4dannjjm 470 2 was be VBD cord-023095-4dannjjm 470 3 a a DT cord-023095-4dannjjm 470 4 significant significant JJ cord-023095-4dannjjm 470 5 positive positive JJ cord-023095-4dannjjm 470 6 correlation correlation NN cord-023095-4dannjjm 470 7 between between IN cord-023095-4dannjjm 470 8 summated summate VBN cord-023095-4dannjjm 470 9 early early JJ cord-023095-4dannjjm 470 10 and and CC cord-023095-4dannjjm 470 11 late late JJ cord-023095-4dannjjm 470 12 diastolic diastolic JJ cord-023095-4dannjjm 470 13 velocities velocity NNS cord-023095-4dannjjm 470 14 ( ( -LRB- cord-023095-4dannjjm 470 15 EmAm EmAm NNP cord-023095-4dannjjm 470 16 ) ) -RRB- cord-023095-4dannjjm 470 17 and and CC cord-023095-4dannjjm 470 18 heart heart NN cord-023095-4dannjjm 470 19 rate rate NN cord-023095-4dannjjm 470 20 ( ( -LRB- cord-023095-4dannjjm 470 21 P p NN cord-023095-4dannjjm 470 22 o o NN cord-023095-4dannjjm 470 23 0,001 0,001 CD cord-023095-4dannjjm 470 24 ) ) -RRB- cord-023095-4dannjjm 470 25 ; ; : cord-023095-4dannjjm 470 26 and and CC cord-023095-4dannjjm 470 27 a a DT cord-023095-4dannjjm 470 28 positive positive JJ cord-023095-4dannjjm 470 29 correlation correlation NN cord-023095-4dannjjm 470 30 between between IN cord-023095-4dannjjm 470 31 Sm Sm NNP cord-023095-4dannjjm 470 32 and and CC cord-023095-4dannjjm 470 33 Em Em NNP cord-023095-4dannjjm 470 34 velocities velocity NNS cord-023095-4dannjjm 470 35 and and CC cord-023095-4dannjjm 470 36 heart heart NN cord-023095-4dannjjm 470 37 rate rate NN cord-023095-4dannjjm 470 38 ( ( -LRB- cord-023095-4dannjjm 470 39 P p NN cord-023095-4dannjjm 470 40 o o NN cord-023095-4dannjjm 470 41 0,01 0,01 NN cord-023095-4dannjjm 470 42 ) ) -RRB- cord-023095-4dannjjm 470 43 . . . cord-023095-4dannjjm 471 1 The the DT cord-023095-4dannjjm 471 2 MYBPC MYBPC NNP cord-023095-4dannjjm 471 3 - - HYPH cord-023095-4dannjjm 471 4 A31P A31P NNP cord-023095-4dannjjm 471 5 mutation mutation NN cord-023095-4dannjjm 471 6 is be VBZ cord-023095-4dannjjm 471 7 not not RB cord-023095-4dannjjm 471 8 consistently consistently RB cord-023095-4dannjjm 471 9 associated associate VBN cord-023095-4dannjjm 471 10 with with IN cord-023095-4dannjjm 471 11 ventricular ventricular JJ cord-023095-4dannjjm 471 12 hypertrophy hypertrophy NN cord-023095-4dannjjm 471 13 and and CC cord-023095-4dannjjm 471 14 negatives negative NNS cord-023095-4dannjjm 471 15 cats cat NNS cord-023095-4dannjjm 471 16 can can MD cord-023095-4dannjjm 471 17 also also RB cord-023095-4dannjjm 471 18 develop develop VB cord-023095-4dannjjm 471 19 HCM HCM NNP cord-023095-4dannjjm 471 20 . . . cord-023095-4dannjjm 472 1 The the DT cord-023095-4dannjjm 472 2 TDI TDI NNP cord-023095-4dannjjm 472 3 alone alone RB cord-023095-4dannjjm 472 4 is be VBZ cord-023095-4dannjjm 472 5 not not RB cord-023095-4dannjjm 472 6 able able JJ cord-023095-4dannjjm 472 7 to to TO cord-023095-4dannjjm 472 8 identify identify VB cord-023095-4dannjjm 472 9 cats cat NNS cord-023095-4dannjjm 472 10 with with IN cord-023095-4dannjjm 472 11 mutation mutation NN cord-023095-4dannjjm 472 12 before before IN cord-023095-4dannjjm 472 13 myocardial myocardial JJ cord-023095-4dannjjm 472 14 hypertrophy hypertrophy NN cord-023095-4dannjjm 472 15 . . . cord-023095-4dannjjm 473 1 Diastolic diastolic JJ cord-023095-4dannjjm 473 2 dysfunction dysfunction NN cord-023095-4dannjjm 473 3 occurs occur VBZ cord-023095-4dannjjm 473 4 in in IN cord-023095-4dannjjm 473 5 many many JJ cord-023095-4dannjjm 473 6 cats cat NNS cord-023095-4dannjjm 473 7 with with IN cord-023095-4dannjjm 473 8 hypertrophic hypertrophic JJ cord-023095-4dannjjm 473 9 cardiomyopathy cardiomyopathy NN cord-023095-4dannjjm 473 10 ( ( -LRB- cord-023095-4dannjjm 473 11 HCM HCM NNP cord-023095-4dannjjm 473 12 ) ) -RRB- cord-023095-4dannjjm 473 13 but but CC cord-023095-4dannjjm 473 14 less less JJR cord-023095-4dannjjm 473 15 is be VBZ cord-023095-4dannjjm 473 16 known know VBN cord-023095-4dannjjm 473 17 about about IN cord-023095-4dannjjm 473 18 systolic systolic JJ cord-023095-4dannjjm 473 19 function function NN cord-023095-4dannjjm 473 20 in in IN cord-023095-4dannjjm 473 21 various various JJ cord-023095-4dannjjm 473 22 stages stage NNS cord-023095-4dannjjm 473 23 of of IN cord-023095-4dannjjm 473 24 HCM HCM NNP cord-023095-4dannjjm 473 25 . . . cord-023095-4dannjjm 474 1 Myocardial myocardial JJ cord-023095-4dannjjm 474 2 strain strain NN cord-023095-4dannjjm 474 3 analysis analysis NN cord-023095-4dannjjm 474 4 by by IN cord-023095-4dannjjm 474 5 tissue tissue NN cord-023095-4dannjjm 474 6 Doppler Doppler NNP cord-023095-4dannjjm 474 7 imaging imaging NN cord-023095-4dannjjm 475 1 is be VBZ cord-023095-4dannjjm 475 2 a a DT cord-023095-4dannjjm 475 3 noninvasive noninvasive JJ cord-023095-4dannjjm 475 4 echocardiographic echocardiographic JJ cord-023095-4dannjjm 475 5 method method NN cord-023095-4dannjjm 475 6 to to TO cord-023095-4dannjjm 475 7 assess assess VB cord-023095-4dannjjm 475 8 systolic systolic JJ cord-023095-4dannjjm 475 9 function function NN cord-023095-4dannjjm 475 10 . . . cord-023095-4dannjjm 476 1 This this DT cord-023095-4dannjjm 476 2 study study NN cord-023095-4dannjjm 476 3 evaluated evaluate VBD cord-023095-4dannjjm 476 4 systolic systolic JJ cord-023095-4dannjjm 476 5 function function NN cord-023095-4dannjjm 476 6 in in IN cord-023095-4dannjjm 476 7 various various JJ cord-023095-4dannjjm 476 8 stages stage NNS cord-023095-4dannjjm 476 9 of of IN cord-023095-4dannjjm 476 10 feline feline JJ cord-023095-4dannjjm 476 11 HCM HCM NNP cord-023095-4dannjjm 476 12 . . . cord-023095-4dannjjm 477 1 Maine Maine NNP cord-023095-4dannjjm 477 2 Coon Coon NNP cord-023095-4dannjjm 477 3 cats cat NNS cord-023095-4dannjjm 477 4 ( ( -LRB- cord-023095-4dannjjm 477 5 n n NN cord-023095-4dannjjm 477 6 5 5 CD cord-023095-4dannjjm 477 7 57 57 CD cord-023095-4dannjjm 477 8 ) ) -RRB- cord-023095-4dannjjm 477 9 were be VBD cord-023095-4dannjjm 477 10 screened screen VBN cord-023095-4dannjjm 477 11 for for IN cord-023095-4dannjjm 477 12 the the DT cord-023095-4dannjjm 477 13 MyBPC MyBPC NNP cord-023095-4dannjjm 477 14 - - HYPH cord-023095-4dannjjm 477 15 A31P A31P NNP cord-023095-4dannjjm 477 16 mutation mutation NN cord-023095-4dannjjm 477 17 an an DT cord-023095-4dannjjm 477 18 examined examine VBN cord-023095-4dannjjm 477 19 with with IN cord-023095-4dannjjm 477 20 both both DT cord-023095-4dannjjm 477 21 echocardiography echocardiography NN cord-023095-4dannjjm 477 22 and and CC cord-023095-4dannjjm 477 23 strain strain NN cord-023095-4dannjjm 477 24 . . . cord-023095-4dannjjm 478 1 Then then RB cord-023095-4dannjjm 478 2 , , , cord-023095-4dannjjm 478 3 were be VBD cord-023095-4dannjjm 478 4 phenotypically phenotypically RB cord-023095-4dannjjm 478 5 classified classify VBN cord-023095-4dannjjm 478 6 in in IN cord-023095-4dannjjm 478 7 : : : cord-023095-4dannjjm 478 8 normal normal JJ cord-023095-4dannjjm 478 9 ( ( -LRB- cord-023095-4dannjjm 478 10 n n NN cord-023095-4dannjjm 478 11 5 5 CD cord-023095-4dannjjm 478 12 45 45 CD cord-023095-4dannjjm 478 13 ) ) -RRB- cord-023095-4dannjjm 478 14 , , , cord-023095-4dannjjm 478 15 suspects suspect NNS cord-023095-4dannjjm 478 16 for for IN cord-023095-4dannjjm 478 17 HCM HCM NNP cord-023095-4dannjjm 478 18 ( ( -LRB- cord-023095-4dannjjm 478 19 n n NN cord-023095-4dannjjm 478 20 5 5 CD cord-023095-4dannjjm 478 21 7 7 CD cord-023095-4dannjjm 478 22 ) ) -RRB- cord-023095-4dannjjm 478 23 and and CC cord-023095-4dannjjm 478 24 HCM HCM NNP cord-023095-4dannjjm 478 25 group group NN cord-023095-4dannjjm 478 26 ( ( -LRB- cord-023095-4dannjjm 478 27 n n NN cord-023095-4dannjjm 478 28 5 5 CD cord-023095-4dannjjm 478 29 5 5 CD cord-023095-4dannjjm 478 30 ) ) -RRB- cord-023095-4dannjjm 478 31 ; ; : cord-023095-4dannjjm 478 32 and and CC cord-023095-4dannjjm 478 33 genotypically genotypically RB cord-023095-4dannjjm 478 34 classified classify VBN cord-023095-4dannjjm 478 35 in in IN cord-023095-4dannjjm 478 36 : : : cord-023095-4dannjjm 478 37 negative negative JJ cord-023095-4dannjjm 478 38 ( ( -LRB- cord-023095-4dannjjm 478 39 n n NN cord-023095-4dannjjm 478 40 5 5 CD cord-023095-4dannjjm 478 41 28 28 CD cord-023095-4dannjjm 478 42 ) ) -RRB- cord-023095-4dannjjm 478 43 , , , cord-023095-4dannjjm 478 44 heterozygous heterozygous JJ cord-023095-4dannjjm 478 45 ( ( -LRB- cord-023095-4dannjjm 478 46 n n NN cord-023095-4dannjjm 478 47 5 5 CD cord-023095-4dannjjm 478 48 26 26 CD cord-023095-4dannjjm 478 49 ) ) -RRB- cord-023095-4dannjjm 478 50 and and CC cord-023095-4dannjjm 478 51 homozygous homozygous JJ cord-023095-4dannjjm 478 52 group group NN cord-023095-4dannjjm 478 53 ( ( -LRB- cord-023095-4dannjjm 478 54 n n NN cord-023095-4dannjjm 478 55 5 5 CD cord-023095-4dannjjm 478 56 3 3 CD cord-023095-4dannjjm 478 57 ) ) -RRB- cord-023095-4dannjjm 478 58 . . . cord-023095-4dannjjm 479 1 Peak peak JJ cord-023095-4dannjjm 479 2 myocardial myocardial JJ cord-023095-4dannjjm 479 3 strain strain NN cord-023095-4dannjjm 479 4 , , , cord-023095-4dannjjm 479 5 measured measure VBN cord-023095-4dannjjm 479 6 in in IN cord-023095-4dannjjm 479 7 the the DT cord-023095-4dannjjm 479 8 basal basal NN cord-023095-4dannjjm 479 9 and and CC cord-023095-4dannjjm 479 10 mildventricular mildventricular JJ cord-023095-4dannjjm 479 11 segment segment NN cord-023095-4dannjjm 479 12 of of IN cord-023095-4dannjjm 479 13 the the DT cord-023095-4dannjjm 479 14 interventricular interventricular JJ cord-023095-4dannjjm 479 15 septal septal JJ cord-023095-4dannjjm 479 16 wall wall NN cord-023095-4dannjjm 479 17 ( ( -LRB- cord-023095-4dannjjm 479 18 IVS IVS NNP cord-023095-4dannjjm 479 19 ) ) -RRB- cord-023095-4dannjjm 479 20 , , , cord-023095-4dannjjm 479 21 left leave VBD cord-023095-4dannjjm 479 22 ventricular ventricular JJ cord-023095-4dannjjm 479 23 free free JJ cord-023095-4dannjjm 479 24 wall wall NN cord-023095-4dannjjm 479 25 ( ( -LRB- cord-023095-4dannjjm 479 26 LVW LVW NNP cord-023095-4dannjjm 479 27 ) ) -RRB- cord-023095-4dannjjm 479 28 , , , cord-023095-4dannjjm 479 29 left leave VBD cord-023095-4dannjjm 479 30 ventricular ventricular JJ cord-023095-4dannjjm 479 31 anterior anterior JJ cord-023095-4dannjjm 479 32 wall wall NN cord-023095-4dannjjm 479 33 ( ( -LRB- cord-023095-4dannjjm 479 34 LVAW LVAW NNP cord-023095-4dannjjm 479 35 ) ) -RRB- cord-023095-4dannjjm 479 36 , , , cord-023095-4dannjjm 479 37 left leave VBD cord-023095-4dannjjm 479 38 ventricular ventricular JJ cord-023095-4dannjjm 479 39 posterior posterior JJ cord-023095-4dannjjm 479 40 wall wall NN cord-023095-4dannjjm 479 41 ( ( -LRB- cord-023095-4dannjjm 479 42 LVPW LVPW NNP cord-023095-4dannjjm 479 43 ) ) -RRB- cord-023095-4dannjjm 479 44 and and CC cord-023095-4dannjjm 479 45 radial radial JJ cord-023095-4dannjjm 479 46 segment segment NN cord-023095-4dannjjm 479 47 of of IN cord-023095-4dannjjm 479 48 left left JJ cord-023095-4dannjjm 479 49 ventricular ventricular JJ cord-023095-4dannjjm 479 50 wall wall NN cord-023095-4dannjjm 479 51 , , , cord-023095-4dannjjm 479 52 was be VBD cord-023095-4dannjjm 479 53 compared compare VBN cord-023095-4dannjjm 479 54 among among IN cord-023095-4dannjjm 479 55 different different JJ cord-023095-4dannjjm 479 56 groups group NNS cord-023095-4dannjjm 479 57 . . . cord-023095-4dannjjm 480 1 Whereas whereas IN cord-023095-4dannjjm 480 2 conventional conventional JJ cord-023095-4dannjjm 480 3 echocardiography echocardiography NN cord-023095-4dannjjm 480 4 demonstrated demonstrate VBD cord-023095-4dannjjm 480 5 an an DT cord-023095-4dannjjm 480 6 apparently apparently RB cord-023095-4dannjjm 480 7 normal normal JJ cord-023095-4dannjjm 480 8 contractile contractile JJ cord-023095-4dannjjm 480 9 state state NN cord-023095-4dannjjm 480 10 based base VBN cord-023095-4dannjjm 480 11 on on IN cord-023095-4dannjjm 480 12 fractional fractional JJ cord-023095-4dannjjm 480 13 shortening shortening NN cord-023095-4dannjjm 480 14 , , , cord-023095-4dannjjm 480 15 myocardial myocardial JJ cord-023095-4dannjjm 480 16 strain strain NN cord-023095-4dannjjm 480 17 ( ( -LRB- cord-023095-4dannjjm 480 18 at at IN cord-023095-4dannjjm 480 19 mildventricular mildventricular NNP cord-023095-4dannjjm 480 20 segment segment NN cord-023095-4dannjjm 480 21 of of IN cord-023095-4dannjjm 480 22 IVS IVS NNP cord-023095-4dannjjm 480 23 ) ) -RRB- cord-023095-4dannjjm 480 24 in in IN cord-023095-4dannjjm 480 25 HCM HCM NNP cord-023095-4dannjjm 480 26 cats cat NNS cord-023095-4dannjjm 480 27 was be VBD cord-023095-4dannjjm 480 28 significantly significantly RB cord-023095-4dannjjm 480 29 decreased decrease VBN cord-023095-4dannjjm 480 30 compared compare VBN cord-023095-4dannjjm 480 31 with with IN cord-023095-4dannjjm 480 32 normal normal JJ cord-023095-4dannjjm 480 33 group group NN cord-023095-4dannjjm 480 34 ( ( -LRB- cord-023095-4dannjjm 480 35 P p NN cord-023095-4dannjjm 480 36 5 5 CD cord-023095-4dannjjm 480 37 0,01 0,01 CD cord-023095-4dannjjm 480 38 ) ) -RRB- cord-023095-4dannjjm 480 39 . . . cord-023095-4dannjjm 481 1 Myocardial myocardial JJ cord-023095-4dannjjm 481 2 strain strain NN cord-023095-4dannjjm 481 3 ( ( -LRB- cord-023095-4dannjjm 481 4 at at IN cord-023095-4dannjjm 481 5 basal basal NN cord-023095-4dannjjm 481 6 segment segment NN cord-023095-4dannjjm 481 7 of of IN cord-023095-4dannjjm 481 8 LVAW LVAW NNP cord-023095-4dannjjm 481 9 ) ) -RRB- cord-023095-4dannjjm 481 10 also also RB cord-023095-4dannjjm 481 11 was be VBD cord-023095-4dannjjm 481 12 significantly significantly RB cord-023095-4dannjjm 481 13 decreased decrease VBN cord-023095-4dannjjm 481 14 in in IN cord-023095-4dannjjm 481 15 heterozygous heterozygous JJ cord-023095-4dannjjm 481 16 cats cat NNS cord-023095-4dannjjm 481 17 compared compare VBN cord-023095-4dannjjm 481 18 with with IN cord-023095-4dannjjm 481 19 negative negative JJ cord-023095-4dannjjm 481 20 group group NN cord-023095-4dannjjm 481 21 ( ( -LRB- cord-023095-4dannjjm 481 22 P p NN cord-023095-4dannjjm 481 23 5 5 CD cord-023095-4dannjjm 481 24 0,00 0,00 NN cord-023095-4dannjjm 481 25 ) ) -RRB- cord-023095-4dannjjm 481 26 ; ; : cord-023095-4dannjjm 481 27 and and CC cord-023095-4dannjjm 481 28 was be VBD cord-023095-4dannjjm 481 29 significantly significantly RB cord-023095-4dannjjm 481 30 decreased decrease VBN cord-023095-4dannjjm 481 31 in in IN cord-023095-4dannjjm 481 32 heterozygous heterozygous JJ cord-023095-4dannjjm 481 33 cats cat NNS cord-023095-4dannjjm 481 34 compared compare VBN cord-023095-4dannjjm 481 35 with with IN cord-023095-4dannjjm 481 36 negative negative JJ cord-023095-4dannjjm 481 37 group group NN cord-023095-4dannjjm 481 38 , , , cord-023095-4dannjjm 481 39 both both CC cord-023095-4dannjjm 481 40 without without IN cord-023095-4dannjjm 481 41 ventricular ventricular JJ cord-023095-4dannjjm 481 42 hypertrophy hypertrophy NN cord-023095-4dannjjm 481 43 ( ( -LRB- cord-023095-4dannjjm 481 44 P p NN cord-023095-4dannjjm 481 45 5 5 CD cord-023095-4dannjjm 481 46 0,019 0,019 CD cord-023095-4dannjjm 481 47 ) ) -RRB- cord-023095-4dannjjm 481 48 . . . cord-023095-4dannjjm 482 1 There there EX cord-023095-4dannjjm 482 2 was be VBD cord-023095-4dannjjm 482 3 a a DT cord-023095-4dannjjm 482 4 significant significant JJ cord-023095-4dannjjm 482 5 negative negative JJ cord-023095-4dannjjm 482 6 correlation correlation NN cord-023095-4dannjjm 482 7 between between IN cord-023095-4dannjjm 482 8 strain strain NN cord-023095-4dannjjm 482 9 values value NNS cord-023095-4dannjjm 482 10 and and CC cord-023095-4dannjjm 482 11 wall wall NN cord-023095-4dannjjm 482 12 thickness thickness NN cord-023095-4dannjjm 482 13 ( ( -LRB- cord-023095-4dannjjm 482 14 P p NN cord-023095-4dannjjm 482 15 o o NN cord-023095-4dannjjm 482 16 0,05 0,05 NN cord-023095-4dannjjm 482 17 ) ) -RRB- cord-023095-4dannjjm 482 18 . . . cord-023095-4dannjjm 483 1 This this DT cord-023095-4dannjjm 483 2 method method NN cord-023095-4dannjjm 483 3 allows allow VBZ cord-023095-4dannjjm 483 4 detection detection NN cord-023095-4dannjjm 483 5 of of IN cord-023095-4dannjjm 483 6 abnormal abnormal JJ cord-023095-4dannjjm 483 7 systolic systolic JJ cord-023095-4dannjjm 483 8 deformation deformation NN cord-023095-4dannjjm 483 9 in in IN cord-023095-4dannjjm 483 10 Maine Maine NNP cord-023095-4dannjjm 483 11 Coons Coons NNPS cord-023095-4dannjjm 483 12 cats cat NNS cord-023095-4dannjjm 483 13 with with IN cord-023095-4dannjjm 483 14 HCM HCM NNP cord-023095-4dannjjm 483 15 mutation mutation NN cord-023095-4dannjjm 483 16 despite despite IN cord-023095-4dannjjm 483 17 apparently apparently RB cord-023095-4dannjjm 483 18 normal normal JJ cord-023095-4dannjjm 483 19 systolic systolic JJ cord-023095-4dannjjm 483 20 function function NN cord-023095-4dannjjm 483 21 . . . cord-023095-4dannjjm 484 1 The the DT cord-023095-4dannjjm 484 2 abnormal abnormal JJ cord-023095-4dannjjm 484 3 systolic systolic JJ cord-023095-4dannjjm 484 4 deformation deformation NN cord-023095-4dannjjm 484 5 already already RB cord-023095-4dannjjm 484 6 can can MD cord-023095-4dannjjm 484 7 be be VB cord-023095-4dannjjm 484 8 present present JJ cord-023095-4dannjjm 484 9 in in IN cord-023095-4dannjjm 484 10 heterozygous heterozygous JJ cord-023095-4dannjjm 484 11 cats cat NNS cord-023095-4dannjjm 484 12 without without IN cord-023095-4dannjjm 484 13 hypertrophy hypertrophy NN cord-023095-4dannjjm 484 14 and and CC cord-023095-4dannjjm 484 15 increased increase VBD cord-023095-4dannjjm 484 16 with with IN cord-023095-4dannjjm 484 17 progressive progressive JJ cord-023095-4dannjjm 484 18 ventricular ventricular JJ cord-023095-4dannjjm 484 19 hypertrophy hypertrophy NN cord-023095-4dannjjm 484 20 . . . cord-023095-4dannjjm 485 1 Recently recently RB cord-023095-4dannjjm 485 2 , , , cord-023095-4dannjjm 485 3 multiple multiple JJ cord-023095-4dannjjm 485 4 advanced advanced JJ cord-023095-4dannjjm 485 5 resting resting NN cord-023095-4dannjjm 485 6 electrocardiographic electrocardiographic NNP cord-023095-4dannjjm 485 7 ( ( -LRB- cord-023095-4dannjjm 485 8 ECG ECG NNP cord-023095-4dannjjm 485 9 ) ) -RRB- cord-023095-4dannjjm 485 10 techniques technique NNS cord-023095-4dannjjm 485 11 have have VBP cord-023095-4dannjjm 485 12 been be VBN cord-023095-4dannjjm 485 13 applied apply VBN cord-023095-4dannjjm 485 14 in in IN cord-023095-4dannjjm 485 15 humans human NNS cord-023095-4dannjjm 485 16 for for IN cord-023095-4dannjjm 485 17 detection detection NN cord-023095-4dannjjm 485 18 of of IN cord-023095-4dannjjm 485 19 cardiac cardiac JJ cord-023095-4dannjjm 485 20 autonomic autonomic JJ cord-023095-4dannjjm 485 21 and and CC cord-023095-4dannjjm 485 22 repolarisation repolarisation NN cord-023095-4dannjjm 485 23 function function NN cord-023095-4dannjjm 485 24 . . . cord-023095-4dannjjm 486 1 This this DT cord-023095-4dannjjm 486 2 has have VBZ cord-023095-4dannjjm 486 3 improved improve VBN cord-023095-4dannjjm 486 4 the the DT cord-023095-4dannjjm 486 5 diagnostic diagnostic JJ cord-023095-4dannjjm 486 6 and/or and/or CC cord-023095-4dannjjm 486 7 prognostic prognostic JJ cord-023095-4dannjjm 486 8 value value NN cord-023095-4dannjjm 486 9 of of IN cord-023095-4dannjjm 486 10 short short JJ cord-023095-4dannjjm 486 11 - - HYPH cord-023095-4dannjjm 486 12 time time NN cord-023095-4dannjjm 486 13 ECG ECG NNP cord-023095-4dannjjm 486 14 in in IN cord-023095-4dannjjm 486 15 detection detection NN cord-023095-4dannjjm 486 16 of of IN cord-023095-4dannjjm 486 17 common common JJ cord-023095-4dannjjm 486 18 human human JJ cord-023095-4dannjjm 486 19 cardiac cardiac JJ cord-023095-4dannjjm 486 20 diseases disease NNS cord-023095-4dannjjm 486 21 even even RB cord-023095-4dannjjm 486 22 before before IN cord-023095-4dannjjm 486 23 onset onset NN cord-023095-4dannjjm 486 24 of of IN cord-023095-4dannjjm 486 25 symptoms symptom NNS cord-023095-4dannjjm 486 26 or or CC cord-023095-4dannjjm 486 27 changes change NNS cord-023095-4dannjjm 486 28 in in IN cord-023095-4dannjjm 486 29 the the DT cord-023095-4dannjjm 486 30 standard standard JJ cord-023095-4dannjjm 486 31 ECG ECG NNP cord-023095-4dannjjm 486 32 . . . cord-023095-4dannjjm 487 1 Therefore therefore RB cord-023095-4dannjjm 487 2 , , , cord-023095-4dannjjm 487 3 this this DT cord-023095-4dannjjm 487 4 study study NN cord-023095-4dannjjm 487 5 investigates investigate VBZ cord-023095-4dannjjm 487 6 , , , cord-023095-4dannjjm 487 7 if if IN cord-023095-4dannjjm 487 8 advanced advanced JJ cord-023095-4dannjjm 487 9 ECG ECG NNP cord-023095-4dannjjm 487 10 can can MD cord-023095-4dannjjm 487 11 predict predict VB cord-023095-4dannjjm 487 12 the the DT cord-023095-4dannjjm 487 13 severity severity NN cord-023095-4dannjjm 487 14 of of IN cord-023095-4dannjjm 487 15 mitral mitral JJ cord-023095-4dannjjm 487 16 regurgitation regurgitation NN cord-023095-4dannjjm 487 17 ( ( -LRB- cord-023095-4dannjjm 487 18 MR MR NNP cord-023095-4dannjjm 487 19 ) ) -RRB- cord-023095-4dannjjm 487 20 in in IN cord-023095-4dannjjm 487 21 dogs dog NNS cord-023095-4dannjjm 487 22 with with IN cord-023095-4dannjjm 487 23 myxomatous myxomatous JJ cord-023095-4dannjjm 487 24 mitral mitral JJ cord-023095-4dannjjm 487 25 valve valve NN cord-023095-4dannjjm 487 26 disease disease NN cord-023095-4dannjjm 487 27 ( ( -LRB- cord-023095-4dannjjm 487 28 MMVD MMVD NNP cord-023095-4dannjjm 487 29 ) ) -RRB- cord-023095-4dannjjm 487 30 and and CC cord-023095-4dannjjm 487 31 thereby thereby RB cord-023095-4dannjjm 487 32 improve improve VB cord-023095-4dannjjm 487 33 the the DT cord-023095-4dannjjm 487 34 diagnostic diagnostic JJ cord-023095-4dannjjm 487 35 value value NN cord-023095-4dannjjm 487 36 of of IN cord-023095-4dannjjm 487 37 ECG ECG NNP cord-023095-4dannjjm 487 38 . . . cord-023095-4dannjjm 488 1 The the DT cord-023095-4dannjjm 488 2 study study NN cord-023095-4dannjjm 488 3 included include VBD cord-023095-4dannjjm 488 4 77 77 CD cord-023095-4dannjjm 488 5 privately privately RB cord-023095-4dannjjm 488 6 owned own VBN cord-023095-4dannjjm 488 7 Cavalier Cavalier NNP cord-023095-4dannjjm 488 8 King King NNP cord-023095-4dannjjm 488 9 Charles Charles NNP cord-023095-4dannjjm 488 10 Spaniels Spaniels NNPS cord-023095-4dannjjm 488 11 ( ( -LRB- cord-023095-4dannjjm 488 12 CKCSs ckcs NNS cord-023095-4dannjjm 488 13 ) ) -RRB- cord-023095-4dannjjm 488 14 ( ( -LRB- cord-023095-4dannjjm 488 15 age age NN cord-023095-4dannjjm 488 16 6.0 6.0 CD cord-023095-4dannjjm 488 17 AE AE NNP cord-023095-4dannjjm 488 18 2.7 2.7 CD cord-023095-4dannjjm 488 19 years year NNS cord-023095-4dannjjm 488 20 ; ; : cord-023095-4dannjjm 488 21 30 30 CD cord-023095-4dannjjm 488 22 males male NNS cord-023095-4dannjjm 488 23 and and CC cord-023095-4dannjjm 488 24 47 47 CD cord-023095-4dannjjm 488 25 females female NNS cord-023095-4dannjjm 488 26 ) ) -RRB- cord-023095-4dannjjm 488 27 . . . cord-023095-4dannjjm 489 1 All all DT cord-023095-4dannjjm 489 2 dogs dog NNS cord-023095-4dannjjm 489 3 were be VBD cord-023095-4dannjjm 489 4 examined examine VBN cord-023095-4dannjjm 489 5 by by IN cord-023095-4dannjjm 489 6 echocardiography echocardiography NN cord-023095-4dannjjm 489 7 and and CC cord-023095-4dannjjm 489 8 a a DT cord-023095-4dannjjm 489 9 short short JJ cord-023095-4dannjjm 489 10 - - HYPH cord-023095-4dannjjm 489 11 time time NN cord-023095-4dannjjm 489 12 ( ( -LRB- cord-023095-4dannjjm 489 13 3 3 CD cord-023095-4dannjjm 489 14 - - SYM cord-023095-4dannjjm 489 15 5 5 CD cord-023095-4dannjjm 489 16 min min NN cord-023095-4dannjjm 489 17 ) ) -RRB- cord-023095-4dannjjm 489 18 high high JJ cord-023095-4dannjjm 489 19 - - HYPH cord-023095-4dannjjm 489 20 fidelity fidelity NN cord-023095-4dannjjm 489 21 12-lead 12-lead JJ cord-023095-4dannjjm 489 22 ECG ECG NNP cord-023095-4dannjjm 489 23 , , , cord-023095-4dannjjm 489 24 with with IN cord-023095-4dannjjm 489 25 the the DT cord-023095-4dannjjm 489 26 dog dog NN cord-023095-4dannjjm 489 27 in in IN cord-023095-4dannjjm 489 28 a a DT cord-023095-4dannjjm 489 29 resting rest VBG cord-023095-4dannjjm 489 30 position position NN cord-023095-4dannjjm 489 31 and and CC cord-023095-4dannjjm 489 32 in in IN cord-023095-4dannjjm 489 33 sinus sinus NN cord-023095-4dannjjm 489 34 rhythm rhythm NN cord-023095-4dannjjm 489 35 . . . cord-023095-4dannjjm 490 1 Dogs dog NNS cord-023095-4dannjjm 490 2 were be VBD cord-023095-4dannjjm 490 3 divided divide VBN cord-023095-4dannjjm 490 4 into into IN cord-023095-4dannjjm 490 5 5 5 CD cord-023095-4dannjjm 490 6 groups group NNS cord-023095-4dannjjm 490 7 according accord VBG cord-023095-4dannjjm 490 8 to to IN cord-023095-4dannjjm 490 9 the the DT cord-023095-4dannjjm 490 10 degree degree NN cord-023095-4dannjjm 490 11 of of IN cord-023095-4dannjjm 490 12 MR MR NNP cord-023095-4dannjjm 490 13 estimated estimate VBD cord-023095-4dannjjm 490 14 as as IN cord-023095-4dannjjm 490 15 the the DT cord-023095-4dannjjm 490 16 percentage percentage NN cord-023095-4dannjjm 490 17 of of IN cord-023095-4dannjjm 490 18 the the DT cord-023095-4dannjjm 490 19 left left JJ cord-023095-4dannjjm 490 20 atrium atrium NN cord-023095-4dannjjm 490 21 area area NN cord-023095-4dannjjm 490 22 using use VBG cord-023095-4dannjjm 490 23 color color NN cord-023095-4dannjjm 490 24 Doppler Doppler NNP cord-023095-4dannjjm 490 25 mapping mapping NN cord-023095-4dannjjm 490 26 ( ( -LRB- cord-023095-4dannjjm 490 27 0 0 CD cord-023095-4dannjjm 490 28 % % NN cord-023095-4dannjjm 490 29 ; ; : cord-023095-4dannjjm 490 30 0 0 CD cord-023095-4dannjjm 490 31 % % NN cord-023095-4dannjjm 490 32 o o NN cord-023095-4dannjjm 490 33 jet jet NN cord-023095-4dannjjm 490 34 15 15 CD cord-023095-4dannjjm 490 35 % % NN cord-023095-4dannjjm 490 36 ; ; : cord-023095-4dannjjm 490 37 15 15 CD cord-023095-4dannjjm 490 38 % % NN cord-023095-4dannjjm 490 39 o o UH cord-023095-4dannjjm 490 40 jet jet NN cord-023095-4dannjjm 490 41 50 50 CD cord-023095-4dannjjm 490 42 % % NN cord-023095-4dannjjm 490 43 ; ; : cord-023095-4dannjjm 490 44 jet jet NN cord-023095-4dannjjm 490 45 4 4 CD cord-023095-4dannjjm 490 46 50 50 CD cord-023095-4dannjjm 490 47 % % NN cord-023095-4dannjjm 490 48 ; ; : cord-023095-4dannjjm 490 49 jet jet NN cord-023095-4dannjjm 490 50 5 5 CD cord-023095-4dannjjm 490 51 100 100 CD cord-023095-4dannjjm 490 52 % % NN cord-023095-4dannjjm 490 53 and and CC cord-023095-4dannjjm 490 54 with with IN cord-023095-4dannjjm 490 55 clinical clinical JJ cord-023095-4dannjjm 490 56 signs sign NNS cord-023095-4dannjjm 490 57 of of IN cord-023095-4dannjjm 490 58 congestive congestive JJ cord-023095-4dannjjm 490 59 heart heart NN cord-023095-4dannjjm 490 60 failure failure NN cord-023095-4dannjjm 490 61 ) ) -RRB- cord-023095-4dannjjm 490 62 . . . cord-023095-4dannjjm 491 1 ECG ECG NNP cord-023095-4dannjjm 491 2 recordings recording NNS cord-023095-4dannjjm 491 3 were be VBD cord-023095-4dannjjm 491 4 evaluated evaluate VBN cord-023095-4dannjjm 491 5 via via IN cord-023095-4dannjjm 491 6 custom custom NN cord-023095-4dannjjm 491 7 software software NN cord-023095-4dannjjm 491 8 programs program NNS cord-023095-4dannjjm 491 9 to to TO cord-023095-4dannjjm 491 10 calculate calculate VB cord-023095-4dannjjm 491 11 76 76 CD cord-023095-4dannjjm 491 12 different different JJ cord-023095-4dannjjm 491 13 parameters parameter NNS cord-023095-4dannjjm 491 14 , , , cord-023095-4dannjjm 491 15 including include VBG cord-023095-4dannjjm 491 16 heart heart NN cord-023095-4dannjjm 491 17 rate rate NN cord-023095-4dannjjm 491 18 variability variability NN cord-023095-4dannjjm 491 19 ( ( -LRB- cord-023095-4dannjjm 491 20 HRV HRV NNP cord-023095-4dannjjm 491 21 ) ) -RRB- cord-023095-4dannjjm 491 22 , , , cord-023095-4dannjjm 491 23 QT qt NN cord-023095-4dannjjm 491 24 variability variability NN cord-023095-4dannjjm 491 25 ( ( -LRB- cord-023095-4dannjjm 491 26 QTV QTV NNP cord-023095-4dannjjm 491 27 ) ) -RRB- cord-023095-4dannjjm 491 28 , , , cord-023095-4dannjjm 491 29 T t NN cord-023095-4dannjjm 491 30 - - HYPH cord-023095-4dannjjm 491 31 wave wave NN cord-023095-4dannjjm 491 32 complexity complexity NN cord-023095-4dannjjm 491 33 , , , cord-023095-4dannjjm 491 34 wave wave NN cord-023095-4dannjjm 491 35 morphology morphology NN cord-023095-4dannjjm 491 36 and and CC cord-023095-4dannjjm 491 37 3-D 3-d JJ cord-023095-4dannjjm 491 38 ECG ECG NNP cord-023095-4dannjjm 491 39 . . . cord-023095-4dannjjm 492 1 One one CD cord-023095-4dannjjm 492 2 - - HYPH cord-023095-4dannjjm 492 3 way way NN cord-023095-4dannjjm 492 4 ANOVA anova NN cord-023095-4dannjjm 492 5 determined determine VBD cord-023095-4dannjjm 492 6 21 21 CD cord-023095-4dannjjm 492 7 ECG ECG NNP cord-023095-4dannjjm 492 8 parameters parameter NNS cord-023095-4dannjjm 492 9 , , , cord-023095-4dannjjm 492 10 which which WDT cord-023095-4dannjjm 492 11 were be VBD cord-023095-4dannjjm 492 12 significantly significantly RB cord-023095-4dannjjm 492 13 different different JJ cord-023095-4dannjjm 492 14 ( ( -LRB- cord-023095-4dannjjm 492 15 P p NN cord-023095-4dannjjm 492 16 o o NN cord-023095-4dannjjm 492 17 0.05 0.05 CD cord-023095-4dannjjm 492 18 ) ) -RRB- cord-023095-4dannjjm 492 19 between between IN cord-023095-4dannjjm 492 20 the the DT cord-023095-4dannjjm 492 21 5 5 CD cord-023095-4dannjjm 492 22 dog dog NN cord-023095-4dannjjm 492 23 groups group NNS cord-023095-4dannjjm 492 24 . . . cord-023095-4dannjjm 493 1 Principal principal JJ cord-023095-4dannjjm 493 2 component component NN cord-023095-4dannjjm 493 3 factor factor NN cord-023095-4dannjjm 493 4 analysis analysis NN cord-023095-4dannjjm 493 5 identified identify VBD cord-023095-4dannjjm 493 6 a a DT cord-023095-4dannjjm 493 7 5factor 5factor CD cord-023095-4dannjjm 493 8 model model NN cord-023095-4dannjjm 493 9 with with IN cord-023095-4dannjjm 493 10 83.2 83.2 CD cord-023095-4dannjjm 493 11 % % NN cord-023095-4dannjjm 493 12 explained explain VBD cord-023095-4dannjjm 493 13 variability variability NN cord-023095-4dannjjm 493 14 . . . cord-023095-4dannjjm 494 1 QRS QRS NNP cord-023095-4dannjjm 494 2 dipolar dipolar JJ cord-023095-4dannjjm 494 3 voltage voltage NN cord-023095-4dannjjm 494 4 and and CC cord-023095-4dannjjm 494 5 two two CD cord-023095-4dannjjm 494 6 repolarization repolarization NN cord-023095-4dannjjm 494 7 indices index NNS cord-023095-4dannjjm 494 8 of of IN cord-023095-4dannjjm 494 9 QTV QTV NNP cord-023095-4dannjjm 494 10 increased increase VBD cord-023095-4dannjjm 494 11 significantly significantly RB cord-023095-4dannjjm 494 12 with with IN cord-023095-4dannjjm 494 13 MR MR NNP cord-023095-4dannjjm 494 14 severity severity NN cord-023095-4dannjjm 494 15 , , , cord-023095-4dannjjm 494 16 whereas whereas IN cord-023095-4dannjjm 494 17 total total JJ cord-023095-4dannjjm 494 18 power power NN cord-023095-4dannjjm 494 19 of of IN cord-023095-4dannjjm 494 20 the the DT cord-023095-4dannjjm 494 21 frequency frequency NN cord-023095-4dannjjm 494 22 spectrum spectrum NN cord-023095-4dannjjm 494 23 of of IN cord-023095-4dannjjm 494 24 RR RR NNP cord-023095-4dannjjm 494 25 interval interval NN cord-023095-4dannjjm 494 26 and and CC cord-023095-4dannjjm 494 27 the the DT cord-023095-4dannjjm 494 28 standard standard JJ cord-023095-4dannjjm 494 29 deviation deviation NN cord-023095-4dannjjm 494 30 of of IN cord-023095-4dannjjm 494 31 QTV QTV NNP cord-023095-4dannjjm 494 32 decreased decrease VBD cord-023095-4dannjjm 494 33 significantly significantly RB cord-023095-4dannjjm 494 34 with with IN cord-023095-4dannjjm 494 35 MR MR NNP cord-023095-4dannjjm 494 36 severity severity NN cord-023095-4dannjjm 494 37 . . . cord-023095-4dannjjm 495 1 For for IN cord-023095-4dannjjm 495 2 the the DT cord-023095-4dannjjm 495 3 5 5 CD cord-023095-4dannjjm 495 4 selected select VBN cord-023095-4dannjjm 495 5 parameters parameter NNS cord-023095-4dannjjm 495 6 the the DT cord-023095-4dannjjm 495 7 prediction prediction NN cord-023095-4dannjjm 495 8 of of IN cord-023095-4dannjjm 495 9 MR MR NNP cord-023095-4dannjjm 495 10 jet jet NN cord-023095-4dannjjm 495 11 value value NN cord-023095-4dannjjm 495 12 was be VBD cord-023095-4dannjjm 495 13 tested test VBN cord-023095-4dannjjm 495 14 by by IN cord-023095-4dannjjm 495 15 multiple multiple JJ cord-023095-4dannjjm 495 16 linear linear JJ cord-023095-4dannjjm 495 17 regression regression NN cord-023095-4dannjjm 495 18 . . . cord-023095-4dannjjm 496 1 A a DT cord-023095-4dannjjm 496 2 correlation correlation NN cord-023095-4dannjjm 496 3 coefficient coefficient NN cord-023095-4dannjjm 496 4 ( ( -LRB- cord-023095-4dannjjm 496 5 R r NN cord-023095-4dannjjm 496 6 ) ) -RRB- cord-023095-4dannjjm 496 7 of of IN cord-023095-4dannjjm 496 8 0.65 0.65 CD cord-023095-4dannjjm 496 9 indicated indicate VBD cord-023095-4dannjjm 496 10 that that IN cord-023095-4dannjjm 496 11 the the DT cord-023095-4dannjjm 496 12 prediction prediction NN cord-023095-4dannjjm 496 13 value value NN cord-023095-4dannjjm 496 14 was be VBD cord-023095-4dannjjm 496 15 significant significant JJ cord-023095-4dannjjm 497 1 ( ( -LRB- cord-023095-4dannjjm 497 2 P p NN cord-023095-4dannjjm 497 3 o o NN cord-023095-4dannjjm 497 4 0.01 0.01 CD cord-023095-4dannjjm 497 5 ) ) -RRB- cord-023095-4dannjjm 497 6 . . . cord-023095-4dannjjm 498 1 If if IN cord-023095-4dannjjm 498 2 age age NN cord-023095-4dannjjm 498 3 was be VBD cord-023095-4dannjjm 498 4 included include VBN cord-023095-4dannjjm 498 5 in in IN cord-023095-4dannjjm 498 6 the the DT cord-023095-4dannjjm 498 7 multiple multiple JJ cord-023095-4dannjjm 498 8 linear linear JJ cord-023095-4dannjjm 498 9 regression regression NN cord-023095-4dannjjm 498 10 the the DT cord-023095-4dannjjm 498 11 prediction prediction NN cord-023095-4dannjjm 498 12 value value NN cord-023095-4dannjjm 498 13 was be VBD cord-023095-4dannjjm 498 14 further further RB cord-023095-4dannjjm 498 15 increased increase VBN cord-023095-4dannjjm 498 16 ( ( -LRB- cord-023095-4dannjjm 498 17 R r NN cord-023095-4dannjjm 498 18 5 5 CD cord-023095-4dannjjm 498 19 0.80 0.80 CD cord-023095-4dannjjm 498 20 ) ) -RRB- cord-023095-4dannjjm 498 21 . . . cord-023095-4dannjjm 499 1 Our -PRON- PRP$ cord-023095-4dannjjm 499 2 results result NNS cord-023095-4dannjjm 499 3 indicate indicate VBP cord-023095-4dannjjm 499 4 that that IN cord-023095-4dannjjm 499 5 for for IN cord-023095-4dannjjm 499 6 a a DT cord-023095-4dannjjm 499 7 cut cut VB cord-023095-4dannjjm 499 8 - - HYPH cord-023095-4dannjjm 499 9 off off RP cord-023095-4dannjjm 499 10 criteria criterion NNS cord-023095-4dannjjm 499 11 of of IN cord-023095-4dannjjm 499 12 MR MR NNP cord-023095-4dannjjm 499 13 ! ! . cord-023095-4dannjjm 500 1 50 50 CD cord-023095-4dannjjm 500 2 % % NN cord-023095-4dannjjm 500 3 jet jet NN cord-023095-4dannjjm 501 1 the the DT cord-023095-4dannjjm 501 2 five five CD cord-023095-4dannjjm 501 3 selected select VBN cord-023095-4dannjjm 501 4 ECG ECG NNP cord-023095-4dannjjm 501 5 parameters parameter NNS cord-023095-4dannjjm 501 6 could could MD cord-023095-4dannjjm 501 7 predict predict VB cord-023095-4dannjjm 501 8 the the DT cord-023095-4dannjjm 501 9 severity severity NN cord-023095-4dannjjm 501 10 of of IN cord-023095-4dannjjm 501 11 MR MR NNP cord-023095-4dannjjm 501 12 caused cause VBN cord-023095-4dannjjm 501 13 by by IN cord-023095-4dannjjm 501 14 MMVD MMVD NNP cord-023095-4dannjjm 501 15 in in IN cord-023095-4dannjjm 501 16 CKCSs ckcs NNS cord-023095-4dannjjm 501 17 with with IN cord-023095-4dannjjm 501 18 sinus sinus NN cord-023095-4dannjjm 501 19 rhythm rhythm NN cord-023095-4dannjjm 501 20 with with IN cord-023095-4dannjjm 501 21 sensitivity sensitivity NN cord-023095-4dannjjm 501 22 65 65 CD cord-023095-4dannjjm 501 23 % % NN cord-023095-4dannjjm 501 24 ( ( -LRB- cord-023095-4dannjjm 501 25 78 78 CD cord-023095-4dannjjm 501 26 % % NN cord-023095-4dannjjm 501 27 with with IN cord-023095-4dannjjm 501 28 age age NN cord-023095-4dannjjm 501 29 inclusion inclusion NN cord-023095-4dannjjm 501 30 ) ) -RRB- cord-023095-4dannjjm 501 31 and and CC cord-023095-4dannjjm 501 32 specificity specificity NN cord-023095-4dannjjm 501 33 98 98 CD cord-023095-4dannjjm 501 34 % % NN cord-023095-4dannjjm 501 35 ( ( -LRB- cord-023095-4dannjjm 501 36 92 92 CD cord-023095-4dannjjm 501 37 % % NN cord-023095-4dannjjm 501 38 with with IN cord-023095-4dannjjm 501 39 age age NN cord-023095-4dannjjm 501 40 inclusion inclusion NN cord-023095-4dannjjm 501 41 ) ) -RRB- cord-023095-4dannjjm 501 42 ( ( -LRB- cord-023095-4dannjjm 501 43 P p NN cord-023095-4dannjjm 501 44 o o NN cord-023095-4dannjjm 501 45 0.05 0.05 CD cord-023095-4dannjjm 501 46 ) ) -RRB- cord-023095-4dannjjm 501 47 . . . cord-023095-4dannjjm 502 1 NT NT NNP cord-023095-4dannjjm 502 2 - - HYPH cord-023095-4dannjjm 502 3 proBNP probnp NN cord-023095-4dannjjm 502 4 concentration concentration NN cord-023095-4dannjjm 502 5 is be VBZ cord-023095-4dannjjm 502 6 increased increase VBN cord-023095-4dannjjm 502 7 in in IN cord-023095-4dannjjm 502 8 canine canine JJ cord-023095-4dannjjm 502 9 patients patient NNS cord-023095-4dannjjm 502 10 with with IN cord-023095-4dannjjm 502 11 heart heart NN cord-023095-4dannjjm 502 12 disease disease NN cord-023095-4dannjjm 502 13 . . . cord-023095-4dannjjm 503 1 Relatively relatively RB cord-023095-4dannjjm 503 2 little little JJ cord-023095-4dannjjm 503 3 is be VBZ cord-023095-4dannjjm 503 4 known know VBN cord-023095-4dannjjm 503 5 about about IN cord-023095-4dannjjm 503 6 the the DT cord-023095-4dannjjm 503 7 stimuli stimulus NNS cord-023095-4dannjjm 503 8 for for IN cord-023095-4dannjjm 503 9 release release NN cord-023095-4dannjjm 503 10 of of IN cord-023095-4dannjjm 503 11 NT NT NNP cord-023095-4dannjjm 503 12 - - HYPH cord-023095-4dannjjm 503 13 proBNP probnp NN cord-023095-4dannjjm 503 14 in in IN cord-023095-4dannjjm 503 15 dogs dog NNS cord-023095-4dannjjm 503 16 . . . cord-023095-4dannjjm 504 1 Physical physical JJ cord-023095-4dannjjm 504 2 activity activity NN cord-023095-4dannjjm 504 3 independent independent JJ cord-023095-4dannjjm 504 4 of of IN cord-023095-4dannjjm 504 5 cardiac cardiac JJ cord-023095-4dannjjm 504 6 disease disease NN cord-023095-4dannjjm 504 7 and and CC cord-023095-4dannjjm 504 8 the the DT cord-023095-4dannjjm 504 9 stress stress NN cord-023095-4dannjjm 504 10 of of IN cord-023095-4dannjjm 504 11 being be VBG cord-023095-4dannjjm 504 12 in in IN cord-023095-4dannjjm 504 13 the the DT cord-023095-4dannjjm 504 14 hospital hospital NN cord-023095-4dannjjm 504 15 could could MD cord-023095-4dannjjm 504 16 influence influence VB cord-023095-4dannjjm 504 17 NT NT NNP cord-023095-4dannjjm 504 18 - - HYPH cord-023095-4dannjjm 504 19 proBNP probnp NN cord-023095-4dannjjm 504 20 release release NN cord-023095-4dannjjm 504 21 and and CC cord-023095-4dannjjm 504 22 affect affect VB cord-023095-4dannjjm 504 23 diagnosis diagnosis NN cord-023095-4dannjjm 504 24 and and CC cord-023095-4dannjjm 504 25 management management NN cord-023095-4dannjjm 504 26 of of IN cord-023095-4dannjjm 504 27 patients patient NNS cord-023095-4dannjjm 504 28 . . . cord-023095-4dannjjm 505 1 We -PRON- PRP cord-023095-4dannjjm 505 2 hypothesized hypothesize VBD cord-023095-4dannjjm 505 3 that that IN cord-023095-4dannjjm 505 4 NT NT NNP cord-023095-4dannjjm 505 5 - - HYPH cord-023095-4dannjjm 505 6 proBNP probnp NN cord-023095-4dannjjm 505 7 concentration concentration NN cord-023095-4dannjjm 505 8 in in IN cord-023095-4dannjjm 505 9 healthy healthy JJ cord-023095-4dannjjm 505 10 dogs dog NNS cord-023095-4dannjjm 505 11 would would MD cord-023095-4dannjjm 505 12 not not RB cord-023095-4dannjjm 505 13 exceed exceed VB cord-023095-4dannjjm 505 14 the the DT cord-023095-4dannjjm 505 15 normal normal JJ cord-023095-4dannjjm 505 16 reference reference NN cord-023095-4dannjjm 505 17 value value NN cord-023095-4dannjjm 505 18 ( ( -LRB- cord-023095-4dannjjm 505 19 900 900 CD cord-023095-4dannjjm 505 20 pmol pmol NN cord-023095-4dannjjm 505 21 / / SYM cord-023095-4dannjjm 505 22 L l NN cord-023095-4dannjjm 505 23 ) ) -RRB- cord-023095-4dannjjm 505 24 following follow VBG cord-023095-4dannjjm 505 25 a a DT cord-023095-4dannjjm 505 26 period period NN cord-023095-4dannjjm 505 27 of of IN cord-023095-4dannjjm 505 28 exercise exercise NN cord-023095-4dannjjm 505 29 . . . cord-023095-4dannjjm 506 1 The the DT cord-023095-4dannjjm 506 2 goal goal NN cord-023095-4dannjjm 506 3 of of IN cord-023095-4dannjjm 506 4 this this DT cord-023095-4dannjjm 506 5 study study NN cord-023095-4dannjjm 506 6 was be VBD cord-023095-4dannjjm 506 7 to to TO cord-023095-4dannjjm 506 8 examine examine VB cord-023095-4dannjjm 506 9 whether whether IN cord-023095-4dannjjm 506 10 physical physical JJ cord-023095-4dannjjm 506 11 activity activity NN cord-023095-4dannjjm 506 12 could could MD cord-023095-4dannjjm 506 13 elevate elevate VB cord-023095-4dannjjm 506 14 plasma plasma NN cord-023095-4dannjjm 506 15 NT nt NN cord-023095-4dannjjm 506 16 - - HYPH cord-023095-4dannjjm 506 17 proBNP probnp NN cord-023095-4dannjjm 506 18 and and CC cord-023095-4dannjjm 506 19 cause cause VB cord-023095-4dannjjm 506 20 false false JJ cord-023095-4dannjjm 506 21 positive positive JJ cord-023095-4dannjjm 506 22 results result NNS cord-023095-4dannjjm 506 23 in in IN cord-023095-4dannjjm 506 24 healthy healthy JJ cord-023095-4dannjjm 506 25 dogs dog NNS cord-023095-4dannjjm 506 26 . . . cord-023095-4dannjjm 507 1 The the DT cord-023095-4dannjjm 507 2 study study NN cord-023095-4dannjjm 507 3 population population NN cord-023095-4dannjjm 507 4 included include VBD cord-023095-4dannjjm 507 5 healthy healthy JJ cord-023095-4dannjjm 507 6 dogs dog NNS cord-023095-4dannjjm 507 7 41 41 CD cord-023095-4dannjjm 507 8 yr yr NN cord-023095-4dannjjm 507 9 of of IN cord-023095-4dannjjm 507 10 age age NN cord-023095-4dannjjm 507 11 without without IN cord-023095-4dannjjm 507 12 heart heart NN cord-023095-4dannjjm 507 13 murmur murmur NN cord-023095-4dannjjm 507 14 or or CC cord-023095-4dannjjm 507 15 known know VBN cord-023095-4dannjjm 507 16 systemic systemic JJ cord-023095-4dannjjm 507 17 disease disease NN cord-023095-4dannjjm 507 18 , , , cord-023095-4dannjjm 507 19 and and CC cord-023095-4dannjjm 507 20 normal normal JJ cord-023095-4dannjjm 507 21 2D 2d NN cord-023095-4dannjjm 507 22 / / SYM cord-023095-4dannjjm 507 23 color color NN cord-023095-4dannjjm 507 24 flow flow NN cord-023095-4dannjjm 507 25 echocardiographic echocardiographic JJ cord-023095-4dannjjm 507 26 exam exam NN cord-023095-4dannjjm 507 27 . . . cord-023095-4dannjjm 508 1 Plasma plasma NN cord-023095-4dannjjm 508 2 samples sample NNS cord-023095-4dannjjm 508 3 for for IN cord-023095-4dannjjm 508 4 NT NT NNP cord-023095-4dannjjm 508 5 - - HYPH cord-023095-4dannjjm 508 6 proBNP proBNP NNP cord-023095-4dannjjm 508 7 were be VBD cord-023095-4dannjjm 508 8 obtained obtain VBN cord-023095-4dannjjm 508 9 before before RB cord-023095-4dannjjm 508 10 , , , cord-023095-4dannjjm 508 11 immediately immediately RB cord-023095-4dannjjm 508 12 after after RB cord-023095-4dannjjm 508 13 , , , cord-023095-4dannjjm 508 14 and and CC cord-023095-4dannjjm 508 15 1 1 CD cord-023095-4dannjjm 508 16 hour hour NN cord-023095-4dannjjm 508 17 after after IN cord-023095-4dannjjm 508 18 a a DT cord-023095-4dannjjm 508 19 standardized standardize VBN cord-023095-4dannjjm 508 20 5-minute 5-minute CD cord-023095-4dannjjm 508 21 submaximal submaximal JJ cord-023095-4dannjjm 508 22 exercise exercise NN cord-023095-4dannjjm 508 23 regimen regimen NN cord-023095-4dannjjm 508 24 . . . cord-023095-4dannjjm 509 1 The the DT cord-023095-4dannjjm 509 2 study study NN cord-023095-4dannjjm 509 3 included include VBD cord-023095-4dannjjm 509 4 14 14 CD cord-023095-4dannjjm 509 5 dogs dog NNS cord-023095-4dannjjm 509 6 with with IN cord-023095-4dannjjm 509 7 a a DT cord-023095-4dannjjm 509 8 median median JJ cord-023095-4dannjjm 509 9 age age NN cord-023095-4dannjjm 509 10 of of IN cord-023095-4dannjjm 509 11 5.3yrs 5.3yrs CD cord-023095-4dannjjm 509 12 and and CC cord-023095-4dannjjm 509 13 included include VBD cord-023095-4dannjjm 509 14 6 6 CD cord-023095-4dannjjm 509 15 females female NNS cord-023095-4dannjjm 509 16 and and CC cord-023095-4dannjjm 509 17 8 8 CD cord-023095-4dannjjm 509 18 males male NNS cord-023095-4dannjjm 509 19 . . . cord-023095-4dannjjm 510 1 There there EX cord-023095-4dannjjm 510 2 was be VBD cord-023095-4dannjjm 510 3 no no DT cord-023095-4dannjjm 510 4 statistical statistical JJ cord-023095-4dannjjm 510 5 difference difference NN cord-023095-4dannjjm 510 6 in in IN cord-023095-4dannjjm 510 7 median median JJ cord-023095-4dannjjm 510 8 plasma plasma NN cord-023095-4dannjjm 510 9 NT nt NN cord-023095-4dannjjm 510 10 - - HYPH cord-023095-4dannjjm 510 11 proBNP probnp NN cord-023095-4dannjjm 510 12 concentration concentration NN cord-023095-4dannjjm 510 13 across across IN cord-023095-4dannjjm 510 14 the the DT cord-023095-4dannjjm 510 15 three three CD cord-023095-4dannjjm 510 16 time time NN cord-023095-4dannjjm 510 17 points point NNS cord-023095-4dannjjm 510 18 ( ( -LRB- cord-023095-4dannjjm 510 19 baseline baseline JJ cord-023095-4dannjjm 510 20 median median NN cord-023095-4dannjjm 510 21 , , , cord-023095-4dannjjm 510 22 617 617 CD cord-023095-4dannjjm 510 23 [ [ -LRB- cord-023095-4dannjjm 510 24 IQR IQR NNP cord-023095-4dannjjm 510 25 , , , cord-023095-4dannjjm 510 26 immediately immediately RB cord-023095-4dannjjm 510 27 post post VBP cord-023095-4dannjjm 510 28 , , , cord-023095-4dannjjm 510 29 ; ; : cord-023095-4dannjjm 510 30 P p NN cord-023095-4dannjjm 510 31 5 5 CD cord-023095-4dannjjm 510 32 0.11 0.11 CD cord-023095-4dannjjm 510 33 ) ) -RRB- cord-023095-4dannjjm 510 34 . . . cord-023095-4dannjjm 511 1 The the DT cord-023095-4dannjjm 511 2 average average JJ cord-023095-4dannjjm 511 3 coefficient coefficient NN cord-023095-4dannjjm 511 4 of of IN cord-023095-4dannjjm 511 5 variation variation NN cord-023095-4dannjjm 511 6 of of IN cord-023095-4dannjjm 511 7 NT NT NNP cord-023095-4dannjjm 511 8 - - HYPH cord-023095-4dannjjm 511 9 proBNP probnp NN cord-023095-4dannjjm 511 10 concentration concentration NN cord-023095-4dannjjm 511 11 across across IN cord-023095-4dannjjm 511 12 the the DT cord-023095-4dannjjm 511 13 exercise exercise NN cord-023095-4dannjjm 511 14 regimen regimen NN cord-023095-4dannjjm 511 15 was be VBD cord-023095-4dannjjm 511 16 23.0 23.0 CD cord-023095-4dannjjm 511 17 AE AE NNP cord-023095-4dannjjm 511 18 18.9 18.9 CD cord-023095-4dannjjm 511 19 % % NN cord-023095-4dannjjm 511 20 . . . cord-023095-4dannjjm 512 1 In in IN cord-023095-4dannjjm 512 2 1 1 CD cord-023095-4dannjjm 512 3 of of IN cord-023095-4dannjjm 512 4 14 14 CD cord-023095-4dannjjm 512 5 dogs dog NNS cord-023095-4dannjjm 512 6 ( ( -LRB- cord-023095-4dannjjm 512 7 7.1 7.1 CD cord-023095-4dannjjm 512 8 % % NN cord-023095-4dannjjm 512 9 ) ) -RRB- cord-023095-4dannjjm 512 10 , , , cord-023095-4dannjjm 512 11 NT NT NNP cord-023095-4dannjjm 512 12 - - HYPH cord-023095-4dannjjm 512 13 proBNP proBNP NNP cord-023095-4dannjjm 512 14 increased increase VBD cord-023095-4dannjjm 512 15 from from IN cord-023095-4dannjjm 512 16 790 790 CD cord-023095-4dannjjm 512 17 to to IN cord-023095-4dannjjm 512 18 1054 1054 CD cord-023095-4dannjjm 512 19 pmol pmol NNP cord-023095-4dannjjm 512 20 / / SYM cord-023095-4dannjjm 512 21 L L NNP cord-023095-4dannjjm 512 22 immediately immediately RB cord-023095-4dannjjm 512 23 after after IN cord-023095-4dannjjm 512 24 exercise exercise NN cord-023095-4dannjjm 512 25 . . . cord-023095-4dannjjm 513 1 The the DT cord-023095-4dannjjm 513 2 results result NNS cord-023095-4dannjjm 513 3 of of IN cord-023095-4dannjjm 513 4 this this DT cord-023095-4dannjjm 513 5 study study NN cord-023095-4dannjjm 513 6 demonstrate demonstrate VBP cord-023095-4dannjjm 513 7 that that IN cord-023095-4dannjjm 513 8 submaximal submaximal JJ cord-023095-4dannjjm 513 9 exercise exercise NN cord-023095-4dannjjm 513 10 does do VBZ cord-023095-4dannjjm 513 11 not not RB cord-023095-4dannjjm 513 12 significantly significantly RB cord-023095-4dannjjm 513 13 change change VB cord-023095-4dannjjm 513 14 median median JJ cord-023095-4dannjjm 513 15 NT NT NNP cord-023095-4dannjjm 513 16 - - HYPH cord-023095-4dannjjm 513 17 proBNP probnp NN cord-023095-4dannjjm 513 18 concentration concentration NN cord-023095-4dannjjm 513 19 and and CC cord-023095-4dannjjm 513 20 the the DT cord-023095-4dannjjm 513 21 incidence incidence NN cord-023095-4dannjjm 513 22 of of IN cord-023095-4dannjjm 513 23 false false JJ cord-023095-4dannjjm 513 24 positive positive JJ cord-023095-4dannjjm 513 25 results result NNS cord-023095-4dannjjm 513 26 is be VBZ cord-023095-4dannjjm 513 27 low low JJ cord-023095-4dannjjm 513 28 . . . cord-023095-4dannjjm 514 1 Further further JJ cord-023095-4dannjjm 514 2 studies study NNS cord-023095-4dannjjm 514 3 should should MD cord-023095-4dannjjm 514 4 investigate investigate VB cord-023095-4dannjjm 514 5 effects effect NNS cord-023095-4dannjjm 514 6 of of IN cord-023095-4dannjjm 514 7 exercise exercise NN cord-023095-4dannjjm 514 8 on on IN cord-023095-4dannjjm 514 9 NT NT NNP cord-023095-4dannjjm 514 10 - - HYPH cord-023095-4dannjjm 514 11 proBNP probnp NN cord-023095-4dannjjm 514 12 concentrations concentration NNS cord-023095-4dannjjm 514 13 in in IN cord-023095-4dannjjm 514 14 dogs dog NNS cord-023095-4dannjjm 514 15 with with IN cord-023095-4dannjjm 514 16 heart heart NN cord-023095-4dannjjm 514 17 disease disease NN cord-023095-4dannjjm 514 18 . . . cord-023095-4dannjjm 515 1 Obesity obesity NN cord-023095-4dannjjm 515 2 is be VBZ cord-023095-4dannjjm 515 3 an an DT cord-023095-4dannjjm 515 4 increasing increase VBG cord-023095-4dannjjm 515 5 problem problem NN cord-023095-4dannjjm 515 6 in in IN cord-023095-4dannjjm 515 7 veterinary veterinary JJ cord-023095-4dannjjm 515 8 medicine medicine NN cord-023095-4dannjjm 515 9 . . . cord-023095-4dannjjm 516 1 Obese obese JJ cord-023095-4dannjjm 516 2 human human JJ cord-023095-4dannjjm 516 3 patients patient NNS cord-023095-4dannjjm 516 4 are be VBP cord-023095-4dannjjm 516 5 shown show VBN cord-023095-4dannjjm 516 6 to to TO cord-023095-4dannjjm 516 7 present present VB cord-023095-4dannjjm 516 8 lower low JJR cord-023095-4dannjjm 516 9 levels level NNS cord-023095-4dannjjm 516 10 of of IN cord-023095-4dannjjm 516 11 natriuretic natriuretic JJ cord-023095-4dannjjm 516 12 peptides peptide NNS cord-023095-4dannjjm 516 13 , , , cord-023095-4dannjjm 516 14 regardless regardless RB cord-023095-4dannjjm 516 15 of of IN cord-023095-4dannjjm 516 16 an an DT cord-023095-4dannjjm 516 17 increased increase VBN cord-023095-4dannjjm 516 18 volume volume NN cord-023095-4dannjjm 516 19 and and CC cord-023095-4dannjjm 516 20 pressure pressure NN cord-023095-4dannjjm 516 21 load load NN cord-023095-4dannjjm 516 22 , , , cord-023095-4dannjjm 516 23 what what WP cord-023095-4dannjjm 516 24 raises raise VBZ cord-023095-4dannjjm 516 25 the the DT cord-023095-4dannjjm 516 26 possibility possibility NN cord-023095-4dannjjm 516 27 that that IN cord-023095-4dannjjm 516 28 the the DT cord-023095-4dannjjm 516 29 natriuretic natriuretic JJ cord-023095-4dannjjm 516 30 response response NN cord-023095-4dannjjm 516 31 is be VBZ cord-023095-4dannjjm 516 32 impaired impair VBN cord-023095-4dannjjm 516 33 in in IN cord-023095-4dannjjm 516 34 these these DT cord-023095-4dannjjm 516 35 individuals individual NNS cord-023095-4dannjjm 516 36 . . . cord-023095-4dannjjm 517 1 Considering consider VBG cord-023095-4dannjjm 517 2 the the DT cord-023095-4dannjjm 517 3 controversial controversial JJ cord-023095-4dannjjm 517 4 findings finding NNS cord-023095-4dannjjm 517 5 in in IN cord-023095-4dannjjm 517 6 obese obese JJ cord-023095-4dannjjm 517 7 humans human NNS cord-023095-4dannjjm 517 8 , , , cord-023095-4dannjjm 517 9 and and CC cord-023095-4dannjjm 517 10 the the DT cord-023095-4dannjjm 517 11 lack lack NN cord-023095-4dannjjm 517 12 of of IN cord-023095-4dannjjm 517 13 studies study NNS cord-023095-4dannjjm 517 14 reported report VBN cord-023095-4dannjjm 517 15 in in IN cord-023095-4dannjjm 517 16 dogs dog NNS cord-023095-4dannjjm 517 17 , , , cord-023095-4dannjjm 517 18 this this DT cord-023095-4dannjjm 517 19 study study NN cord-023095-4dannjjm 517 20 proposed propose VBD cord-023095-4dannjjm 517 21 the the DT cord-023095-4dannjjm 517 22 evaluation evaluation NN cord-023095-4dannjjm 517 23 of of IN cord-023095-4dannjjm 517 24 Nt Nt NNP cord-023095-4dannjjm 517 25 - - HYPH cord-023095-4dannjjm 517 26 proANP proanp NN cord-023095-4dannjjm 517 27 concentration concentration NN cord-023095-4dannjjm 517 28 in in IN cord-023095-4dannjjm 517 29 obese obese JJ cord-023095-4dannjjm 517 30 dogs dog NNS cord-023095-4dannjjm 517 31 . . . cord-023095-4dannjjm 518 1 Nt Nt NNP cord-023095-4dannjjm 518 2 - - HYPH cord-023095-4dannjjm 518 3 proANP proanp NN cord-023095-4dannjjm 518 4 concentration concentration NN cord-023095-4dannjjm 518 5 was be VBD cord-023095-4dannjjm 518 6 determined determine VBN cord-023095-4dannjjm 518 7 prospectively prospectively RB cord-023095-4dannjjm 518 8 in in IN cord-023095-4dannjjm 518 9 39 39 CD cord-023095-4dannjjm 518 10 obese obese JJ cord-023095-4dannjjm 518 11 dogs dog NNS cord-023095-4dannjjm 518 12 ( ( -LRB- cord-023095-4dannjjm 518 13 27 27 CD cord-023095-4dannjjm 518 14 females female NNS cord-023095-4dannjjm 518 15 ; ; : cord-023095-4dannjjm 518 16 12 12 CD cord-023095-4dannjjm 518 17 males male NNS cord-023095-4dannjjm 518 18 ; ; : cord-023095-4dannjjm 518 19 6 6 CD cord-023095-4dannjjm 518 20 - - SYM cord-023095-4dannjjm 518 21 108 108 CD cord-023095-4dannjjm 518 22 months month NNS cord-023095-4dannjjm 518 23 ) ) -RRB- cord-023095-4dannjjm 518 24 and and CC cord-023095-4dannjjm 518 25 in in IN cord-023095-4dannjjm 518 26 23 23 CD cord-023095-4dannjjm 518 27 non non JJ cord-023095-4dannjjm 518 28 - - JJ cord-023095-4dannjjm 518 29 obese obese JJ cord-023095-4dannjjm 518 30 dogs dog NNS cord-023095-4dannjjm 518 31 ( ( -LRB- cord-023095-4dannjjm 518 32 controls control NNS cord-023095-4dannjjm 518 33 ; ; : cord-023095-4dannjjm 518 34 13 13 CD cord-023095-4dannjjm 518 35 females female NNS cord-023095-4dannjjm 518 36 ; ; : cord-023095-4dannjjm 518 37 10 10 CD cord-023095-4dannjjm 518 38 males male NNS cord-023095-4dannjjm 518 39 ; ; : cord-023095-4dannjjm 518 40 12 12 CD cord-023095-4dannjjm 518 41 - - SYM cord-023095-4dannjjm 518 42 108 108 CD cord-023095-4dannjjm 518 43 months month NNS cord-023095-4dannjjm 518 44 ) ) -RRB- cord-023095-4dannjjm 518 45 from from IN cord-023095-4dannjjm 518 46 a a DT cord-023095-4dannjjm 518 47 veterinary veterinary JJ cord-023095-4dannjjm 518 48 hospital hospital NN cord-023095-4dannjjm 518 49 population population NN cord-023095-4dannjjm 518 50 . . . cord-023095-4dannjjm 519 1 Obesity obesity NN cord-023095-4dannjjm 519 2 was be VBD cord-023095-4dannjjm 519 3 determined determine VBN cord-023095-4dannjjm 519 4 by by IN cord-023095-4dannjjm 519 5 body body NN cord-023095-4dannjjm 519 6 condition condition NN cord-023095-4dannjjm 519 7 score score NN cord-023095-4dannjjm 519 8 [ [ -LRB- cord-023095-4dannjjm 519 9 2 2 CD cord-023095-4dannjjm 519 10 ( ( -LRB- cord-023095-4dannjjm 519 11 4/9 4/9 CD cord-023095-4dannjjm 519 12 ) ) -RRB- cord-023095-4dannjjm 519 13 ; ; : cord-023095-4dannjjm 519 14 21 21 CD cord-023095-4dannjjm 519 15 ( ( -LRB- cord-023095-4dannjjm 519 16 5/9 5/9 CD cord-023095-4dannjjm 519 17 ) ) -RRB- cord-023095-4dannjjm 519 18 ; ; : cord-023095-4dannjjm 519 19 1 1 LS cord-023095-4dannjjm 519 20 ( ( -LRB- cord-023095-4dannjjm 519 21 6/9 6/9 CD cord-023095-4dannjjm 519 22 ) ) -RRB- cord-023095-4dannjjm 519 23 ; ; : cord-023095-4dannjjm 519 24 3 3 LS cord-023095-4dannjjm 519 25 ( ( -LRB- cord-023095-4dannjjm 519 26 7/9 7/9 CD cord-023095-4dannjjm 519 27 ) ) -RRB- cord-023095-4dannjjm 519 28 ; ; : cord-023095-4dannjjm 519 29 19 19 CD cord-023095-4dannjjm 519 30 ( ( -LRB- cord-023095-4dannjjm 519 31 8/9 8/9 CD cord-023095-4dannjjm 519 32 ) ) -RRB- cord-023095-4dannjjm 519 33 ; ; : cord-023095-4dannjjm 519 34 18 18 CD cord-023095-4dannjjm 519 35 ( ( -LRB- cord-023095-4dannjjm 519 36 9/9 9/9 CD cord-023095-4dannjjm 519 37 ) ) -RRB- cord-023095-4dannjjm 519 38 ] ] -RRB- cord-023095-4dannjjm 519 39 . . . cord-023095-4dannjjm 520 1 Dogs dog NNS cord-023095-4dannjjm 520 2 were be VBD cord-023095-4dannjjm 520 3 excluded exclude VBN cord-023095-4dannjjm 520 4 if if IN cord-023095-4dannjjm 520 5 they -PRON- PRP cord-023095-4dannjjm 520 6 had have VBD cord-023095-4dannjjm 520 7 any any DT cord-023095-4dannjjm 520 8 primary primary JJ cord-023095-4dannjjm 520 9 cardiac cardiac JJ cord-023095-4dannjjm 520 10 disease disease NN cord-023095-4dannjjm 520 11 , , , cord-023095-4dannjjm 520 12 renal renal JJ cord-023095-4dannjjm 520 13 insufficiency insufficiency NN cord-023095-4dannjjm 520 14 , , , cord-023095-4dannjjm 520 15 endocrine endocrine JJ cord-023095-4dannjjm 520 16 disease disease NN cord-023095-4dannjjm 520 17 , , , cord-023095-4dannjjm 520 18 or or CC cord-023095-4dannjjm 520 19 if if IN cord-023095-4dannjjm 520 20 they -PRON- PRP cord-023095-4dannjjm 520 21 were be VBD cord-023095-4dannjjm 520 22 receiving receive VBG cord-023095-4dannjjm 520 23 diuretics diuretic NNS cord-023095-4dannjjm 520 24 , , , cord-023095-4dannjjm 520 25 vasodilators vasodilator NNS cord-023095-4dannjjm 520 26 , , , cord-023095-4dannjjm 520 27 antiepileptic antiepileptic JJ cord-023095-4dannjjm 520 28 drugs drug NNS cord-023095-4dannjjm 520 29 or or CC cord-023095-4dannjjm 520 30 corticosteroids corticosteroid NNS cord-023095-4dannjjm 520 31 . . . cord-023095-4dannjjm 521 1 Commercial commercial JJ cord-023095-4dannjjm 521 2 kits kit NNS cord-023095-4dannjjm 521 3 were be VBD cord-023095-4dannjjm 521 4 used use VBN cord-023095-4dannjjm 522 1 ( ( -LRB- cord-023095-4dannjjm 522 2 Vetsign Vetsign NNP cord-023095-4dannjjm 522 3 s s POS cord-023095-4dannjjm 522 4 Canine Canine NNP cord-023095-4dannjjm 522 5 Cardio cardio NN cord-023095-4dannjjm 522 6 Screen screen NN cord-023095-4dannjjm 522 7 Nt nt NN cord-023095-4dannjjm 522 8 - - HYPH cord-023095-4dannjjm 522 9 pro pro JJ cord-023095-4dannjjm 522 10 - - JJ cord-023095-4dannjjm 522 11 ANP ANP NNP cord-023095-4dannjjm 522 12 VC3167 VC3167 NNS cord-023095-4dannjjm 522 13 -Guildhay -Guildhay NNP cord-023095-4dannjjm 522 14 / / SYM cord-023095-4dannjjm 522 15 Biomedica Biomedica NNP cord-023095-4dannjjm 522 16 ) ) -RRB- cord-023095-4dannjjm 522 17 . . . cord-023095-4dannjjm 523 1 Mann Mann NNP cord-023095-4dannjjm 523 2 Whitney Whitney NNP cord-023095-4dannjjm 523 3 test test NN cord-023095-4dannjjm 523 4 was be VBD cord-023095-4dannjjm 523 5 used use VBN cord-023095-4dannjjm 523 6 for for IN cord-023095-4dannjjm 523 7 group group NN cord-023095-4dannjjm 523 8 comparison comparison NN cord-023095-4dannjjm 523 9 . . . cord-023095-4dannjjm 524 1 Results result NNS cord-023095-4dannjjm 524 2 are be VBP cord-023095-4dannjjm 524 3 presented present VBN cord-023095-4dannjjm 524 4 as as IN cord-023095-4dannjjm 524 5 median median NN cord-023095-4dannjjm 524 6 ; ; : cord-023095-4dannjjm 524 7 interval interval NN cord-023095-4dannjjm 524 8 ; ; : cord-023095-4dannjjm 524 9 P25 P25 NNP cord-023095-4dannjjm 524 10 and and CC cord-023095-4dannjjm 524 11 P75 P75 NNP cord-023095-4dannjjm 524 12 ) ) -RRB- cord-023095-4dannjjm 524 13 . . . cord-023095-4dannjjm 525 1 Nt Nt NNP cord-023095-4dannjjm 525 2 - - HYPH cord-023095-4dannjjm 525 3 proANP proANP NNP cord-023095-4dannjjm 525 4 was be VBD cord-023095-4dannjjm 525 5 significantly significantly RB cord-023095-4dannjjm 525 6 lower low JJR cord-023095-4dannjjm 525 7 in in IN cord-023095-4dannjjm 525 8 obese obese JJ cord-023095-4dannjjm 525 9 dogs dog NNS cord-023095-4dannjjm 525 10 [ [ -LRB- cord-023095-4dannjjm 525 11 413.56fmol 413.56fmol CD cord-023095-4dannjjm 525 12 / / SYM cord-023095-4dannjjm 525 13 mL ml NN cord-023095-4dannjjm 525 14 ( ( -LRB- cord-023095-4dannjjm 525 15 0.0 0.0 CD cord-023095-4dannjjm 525 16 - - SYM cord-023095-4dannjjm 525 17 1287.14 1287.14 CD cord-023095-4dannjjm 525 18 ) ) -RRB- cord-023095-4dannjjm 525 19 ; ; : cord-023095-4dannjjm 525 20 P25 P25 NNP cord-023095-4dannjjm 525 21 5 5 CD cord-023095-4dannjjm 525 22 228.673 228.673 CD cord-023095-4dannjjm 525 23 ; ; : cord-023095-4dannjjm 525 24 P75 P75 NNP cord-023095-4dannjjm 525 25 5 5 CD cord-023095-4dannjjm 525 26 595.205 595.205 CD cord-023095-4dannjjm 525 27 ] ] -RRB- cord-023095-4dannjjm 525 28 than than IN cord-023095-4dannjjm 525 29 in in IN cord-023095-4dannjjm 525 30 controls control NNS cord-023095-4dannjjm 525 31 [ [ -LRB- cord-023095-4dannjjm 525 32 647.98fmol 647.98fmol CD cord-023095-4dannjjm 525 33 / / SYM cord-023095-4dannjjm 525 34 mL mL NNP cord-023095-4dannjjm 525 35 ( ( -LRB- cord-023095-4dannjjm 525 36 34.99 34.99 CD cord-023095-4dannjjm 525 37 - - SYM cord-023095-4dannjjm 525 38 1596.82 1596.82 CD cord-023095-4dannjjm 525 39 ) ) -RRB- cord-023095-4dannjjm 525 40 ; ; : cord-023095-4dannjjm 525 41 P25 P25 NNP cord-023095-4dannjjm 525 42 5 5 CD cord-023095-4dannjjm 525 43 490.785 490.785 CD cord-023095-4dannjjm 525 44 ; ; : cord-023095-4dannjjm 525 45 P75 P75 NNP cord-023095-4dannjjm 525 46 5 5 CD cord-023095-4dannjjm 526 1 957.055 957.055 LS cord-023095-4dannjjm 526 2 ] ] -RRB- cord-023095-4dannjjm 526 3 ; ; : cord-023095-4dannjjm 526 4 ( ( -LRB- cord-023095-4dannjjm 526 5 P p NN cord-023095-4dannjjm 526 6 5 5 CD cord-023095-4dannjjm 526 7 0.004 0.004 CD cord-023095-4dannjjm 526 8 ) ) -RRB- cord-023095-4dannjjm 526 9 . . . cord-023095-4dannjjm 527 1 Results result NNS cord-023095-4dannjjm 527 2 were be VBD cord-023095-4dannjjm 527 3 similar similar JJ cord-023095-4dannjjm 527 4 to to IN cord-023095-4dannjjm 527 5 what what WP cord-023095-4dannjjm 527 6 has have VBZ cord-023095-4dannjjm 527 7 been be VBN cord-023095-4dannjjm 527 8 found find VBN cord-023095-4dannjjm 527 9 in in IN cord-023095-4dannjjm 527 10 obese obese JJ cord-023095-4dannjjm 527 11 humans human NNS cord-023095-4dannjjm 527 12 . . . cord-023095-4dannjjm 528 1 Lower low JJR cord-023095-4dannjjm 528 2 levels level NNS cord-023095-4dannjjm 528 3 of of IN cord-023095-4dannjjm 528 4 natriuretic natriuretic JJ cord-023095-4dannjjm 528 5 peptides peptide NNS cord-023095-4dannjjm 528 6 are be VBP cord-023095-4dannjjm 528 7 also also RB cord-023095-4dannjjm 528 8 seen see VBN cord-023095-4dannjjm 528 9 in in IN cord-023095-4dannjjm 528 10 obese obese JJ cord-023095-4dannjjm 528 11 heart heart NN cord-023095-4dannjjm 528 12 failure failure NN cord-023095-4dannjjm 528 13 patients patient NNS cord-023095-4dannjjm 528 14 . . . cord-023095-4dannjjm 529 1 This this DT cord-023095-4dannjjm 529 2 study study NN cord-023095-4dannjjm 529 3 provides provide VBZ cord-023095-4dannjjm 529 4 important important JJ cord-023095-4dannjjm 529 5 information information NN cord-023095-4dannjjm 529 6 regarding regard VBG cord-023095-4dannjjm 529 7 Nt Nt NNP cord-023095-4dannjjm 529 8 - - HYPH cord-023095-4dannjjm 529 9 proANP proanp NN cord-023095-4dannjjm 529 10 concentration concentration NN cord-023095-4dannjjm 529 11 in in IN cord-023095-4dannjjm 529 12 obese obese JJ cord-023095-4dannjjm 529 13 dogs dog NNS cord-023095-4dannjjm 529 14 , , , cord-023095-4dannjjm 529 15 which which WDT cord-023095-4dannjjm 529 16 should should MD cord-023095-4dannjjm 529 17 be be VB cord-023095-4dannjjm 529 18 better well RBR cord-023095-4dannjjm 529 19 explored explore VBN cord-023095-4dannjjm 529 20 characterizing characterize VBG cord-023095-4dannjjm 529 21 the the DT cord-023095-4dannjjm 529 22 behavior behavior NN cord-023095-4dannjjm 529 23 of of IN cord-023095-4dannjjm 529 24 natriuretic natriuretic JJ cord-023095-4dannjjm 529 25 peptides peptide NNS cord-023095-4dannjjm 529 26 after after IN cord-023095-4dannjjm 529 27 weight weight NN cord-023095-4dannjjm 529 28 loss loss NN cord-023095-4dannjjm 529 29 , , , cord-023095-4dannjjm 529 30 and and CC cord-023095-4dannjjm 529 31 also also RB cord-023095-4dannjjm 529 32 in in IN cord-023095-4dannjjm 529 33 obese obese JJ cord-023095-4dannjjm 529 34 dogs dog NNS cord-023095-4dannjjm 529 35 with with IN cord-023095-4dannjjm 529 36 primary primary JJ cord-023095-4dannjjm 529 37 heart heart NN cord-023095-4dannjjm 529 38 disease disease NN cord-023095-4dannjjm 529 39 . . . cord-023095-4dannjjm 530 1 Left leave VBN cord-023095-4dannjjm 530 2 - - HYPH cord-023095-4dannjjm 530 3 to to IN cord-023095-4dannjjm 530 4 - - HYPH cord-023095-4dannjjm 530 5 right right JJ cord-023095-4dannjjm 530 6 shunting shunt VBG cord-023095-4dannjjm 530 7 patent patent NN cord-023095-4dannjjm 530 8 ductus ductus NN cord-023095-4dannjjm 530 9 arteriosus arteriosus NN cord-023095-4dannjjm 530 10 ( ( -LRB- cord-023095-4dannjjm 530 11 PDA PDA NNP cord-023095-4dannjjm 530 12 ) ) -RRB- cord-023095-4dannjjm 530 13 is be VBZ cord-023095-4dannjjm 530 14 one one CD cord-023095-4dannjjm 530 15 of of IN cord-023095-4dannjjm 530 16 the the DT cord-023095-4dannjjm 530 17 most most RBS cord-023095-4dannjjm 530 18 common common JJ cord-023095-4dannjjm 530 19 canine canine JJ cord-023095-4dannjjm 530 20 congenital congenital JJ cord-023095-4dannjjm 530 21 cardiovascular cardiovascular JJ cord-023095-4dannjjm 530 22 defects defect NNS cord-023095-4dannjjm 530 23 . . . cord-023095-4dannjjm 531 1 Human human JJ cord-023095-4dannjjm 531 2 studies study NNS cord-023095-4dannjjm 531 3 have have VBP cord-023095-4dannjjm 531 4 shown show VBN cord-023095-4dannjjm 531 5 that that IN cord-023095-4dannjjm 531 6 BNP BNP NNP cord-023095-4dannjjm 531 7 and and CC cord-023095-4dannjjm 531 8 NT NT NNP cord-023095-4dannjjm 531 9 - - HYPH cord-023095-4dannjjm 531 10 proBNP probnp NN cord-023095-4dannjjm 531 11 concentrations concentration NNS cord-023095-4dannjjm 531 12 are be VBP cord-023095-4dannjjm 531 13 elevated elevate VBN cord-023095-4dannjjm 531 14 in in IN cord-023095-4dannjjm 531 15 patients patient NNS cord-023095-4dannjjm 531 16 with with IN cord-023095-4dannjjm 531 17 PDA PDA NNP cord-023095-4dannjjm 531 18 , , , cord-023095-4dannjjm 531 19 and and CC cord-023095-4dannjjm 531 20 can can MD cord-023095-4dannjjm 531 21 be be VB cord-023095-4dannjjm 531 22 used use VBN cord-023095-4dannjjm 531 23 to to TO cord-023095-4dannjjm 531 24 detect detect VB cord-023095-4dannjjm 531 25 hemodynamically hemodynamically RB cord-023095-4dannjjm 531 26 significant significant JJ cord-023095-4dannjjm 531 27 PDA pda NN cord-023095-4dannjjm 531 28 . . . cord-023095-4dannjjm 532 1 The the DT cord-023095-4dannjjm 532 2 purpose purpose NN cord-023095-4dannjjm 532 3 of of IN cord-023095-4dannjjm 532 4 this this DT cord-023095-4dannjjm 532 5 study study NN cord-023095-4dannjjm 532 6 was be VBD cord-023095-4dannjjm 532 7 to to TO cord-023095-4dannjjm 532 8 measure measure VB cord-023095-4dannjjm 532 9 NT NT NNP cord-023095-4dannjjm 532 10 - - HYPH cord-023095-4dannjjm 532 11 proBNP probnp NN cord-023095-4dannjjm 532 12 concentrations concentration NNS cord-023095-4dannjjm 532 13 in in IN cord-023095-4dannjjm 532 14 dogs dog NNS cord-023095-4dannjjm 532 15 with with IN cord-023095-4dannjjm 532 16 PDA PDA NNP cord-023095-4dannjjm 532 17 , , , cord-023095-4dannjjm 532 18 and and CC cord-023095-4dannjjm 532 19 to to TO cord-023095-4dannjjm 532 20 assess assess VB cord-023095-4dannjjm 532 21 whether whether IN cord-023095-4dannjjm 532 22 additional additional JJ cord-023095-4dannjjm 532 23 indicators indicator NNS cord-023095-4dannjjm 532 24 of of IN cord-023095-4dannjjm 532 25 hemodynamics hemodynamic NNS cord-023095-4dannjjm 532 26 correlate correlate VBP cord-023095-4dannjjm 532 27 with with IN cord-023095-4dannjjm 532 28 NTproBNP NTproBNP NNP cord-023095-4dannjjm 532 29 . . . cord-023095-4dannjjm 533 1 We -PRON- PRP cord-023095-4dannjjm 533 2 hypothesized hypothesize VBD cord-023095-4dannjjm 533 3 that that IN cord-023095-4dannjjm 533 4 NT NT NNP cord-023095-4dannjjm 533 5 - - HYPH cord-023095-4dannjjm 533 6 proBNP proBNP NNP cord-023095-4dannjjm 533 7 will will MD cord-023095-4dannjjm 533 8 serve serve VB cord-023095-4dannjjm 533 9 as as IN cord-023095-4dannjjm 533 10 a a DT cord-023095-4dannjjm 533 11 simple simple JJ cord-023095-4dannjjm 533 12 non non JJ cord-023095-4dannjjm 533 13 - - JJ cord-023095-4dannjjm 533 14 invasive invasive JJ cord-023095-4dannjjm 533 15 marker marker NN cord-023095-4dannjjm 533 16 of of IN cord-023095-4dannjjm 533 17 hemodynamic hemodynamic JJ cord-023095-4dannjjm 533 18 significance significance NN cord-023095-4dannjjm 533 19 in in IN cord-023095-4dannjjm 533 20 dogs dog NNS cord-023095-4dannjjm 533 21 with with IN cord-023095-4dannjjm 533 22 PDA PDA NNP cord-023095-4dannjjm 533 23 prior prior RB cord-023095-4dannjjm 533 24 to to IN cord-023095-4dannjjm 533 25 and and CC cord-023095-4dannjjm 533 26 following follow VBG cord-023095-4dannjjm 533 27 transcatheter transcatheter NNP cord-023095-4dannjjm 533 28 ductal ductal JJ cord-023095-4dannjjm 533 29 occlusion occlusion NN cord-023095-4dannjjm 533 30 . . . cord-023095-4dannjjm 534 1 NT NT NNP cord-023095-4dannjjm 534 2 - - HYPH cord-023095-4dannjjm 534 3 proBNP proBNP NNP cord-023095-4dannjjm 534 4 was be VBD cord-023095-4dannjjm 534 5 measured measure VBN cord-023095-4dannjjm 534 6 in in IN cord-023095-4dannjjm 534 7 30 30 CD cord-023095-4dannjjm 534 8 client client NN cord-023095-4dannjjm 534 9 - - HYPH cord-023095-4dannjjm 534 10 owned own VBN cord-023095-4dannjjm 534 11 dogs dog NNS cord-023095-4dannjjm 534 12 with with IN cord-023095-4dannjjm 534 13 echocardiographically echocardiographically RB cord-023095-4dannjjm 534 14 normal normal JJ cord-023095-4dannjjm 534 15 hearts heart NNS cord-023095-4dannjjm 534 16 . . . cord-023095-4dannjjm 535 1 Ten ten CD cord-023095-4dannjjm 535 2 dogs dog NNS cord-023095-4dannjjm 535 3 with with IN cord-023095-4dannjjm 535 4 PDA PDA NNP cord-023095-4dannjjm 535 5 were be VBD cord-023095-4dannjjm 535 6 initially initially RB cord-023095-4dannjjm 535 7 evaluated evaluate VBN cord-023095-4dannjjm 535 8 with with IN cord-023095-4dannjjm 535 9 thoracic thoracic JJ cord-023095-4dannjjm 535 10 radiographs radiograph NNS cord-023095-4dannjjm 535 11 , , , cord-023095-4dannjjm 535 12 transthoracic transthoracic NNP cord-023095-4dannjjm 535 13 and and CC cord-023095-4dannjjm 535 14 transesophageal transesophageal NN cord-023095-4dannjjm 535 15 echocardiography echocardiography NN cord-023095-4dannjjm 535 16 , , , cord-023095-4dannjjm 535 17 pulmonary pulmonary JJ cord-023095-4dannjjm 535 18 capillary capillary NN cord-023095-4dannjjm 535 19 wedge wedge NN cord-023095-4dannjjm 535 20 pressure pressure NN cord-023095-4dannjjm 535 21 ( ( -LRB- cord-023095-4dannjjm 535 22 PCWP PCWP NNP cord-023095-4dannjjm 535 23 ) ) -RRB- cord-023095-4dannjjm 535 24 and and CC cord-023095-4dannjjm 535 25 NT NT NNP cord-023095-4dannjjm 535 26 - - HYPH cord-023095-4dannjjm 535 27 proBNP probnp NN cord-023095-4dannjjm 535 28 . . . cord-023095-4dannjjm 536 1 NT NT NNP cord-023095-4dannjjm 536 2 - - HYPH cord-023095-4dannjjm 536 3 proBNP probnp NN cord-023095-4dannjjm 536 4 and and CC cord-023095-4dannjjm 536 5 echocardiography echocardiography NN cord-023095-4dannjjm 536 6 were be VBD cord-023095-4dannjjm 536 7 repeated repeat VBN cord-023095-4dannjjm 536 8 at at IN cord-023095-4dannjjm 536 9 1 1 CD cord-023095-4dannjjm 536 10 day day NN cord-023095-4dannjjm 536 11 and and CC cord-023095-4dannjjm 536 12 3 3 CD cord-023095-4dannjjm 536 13 months month NNS cord-023095-4dannjjm 536 14 following follow VBG cord-023095-4dannjjm 536 15 ductal ductal JJ cord-023095-4dannjjm 536 16 occlusion occlusion NN cord-023095-4dannjjm 536 17 . . . cord-023095-4dannjjm 537 1 PCWP PCWP NNP cord-023095-4dannjjm 537 2 was be VBD cord-023095-4dannjjm 537 3 repeated repeat VBN cord-023095-4dannjjm 537 4 at at IN cord-023095-4dannjjm 537 5 3 3 CD cord-023095-4dannjjm 537 6 months month NNS cord-023095-4dannjjm 537 7 . . . cord-023095-4dannjjm 538 1 Baseline baseline JJ cord-023095-4dannjjm 538 2 NT NT NNP cord-023095-4dannjjm 538 3 - - HYPH cord-023095-4dannjjm 538 4 proBNP proBNP NNP cord-023095-4dannjjm 538 5 was be VBD cord-023095-4dannjjm 538 6 significantly significantly RB cord-023095-4dannjjm 538 7 higher high JJR cord-023095-4dannjjm 538 8 in in IN cord-023095-4dannjjm 538 9 PDA PDA NNP cord-023095-4dannjjm 538 10 dogs dog NNS cord-023095-4dannjjm 538 11 compared compare VBN cord-023095-4dannjjm 538 12 to to IN cord-023095-4dannjjm 538 13 control control NN cord-023095-4dannjjm 538 14 ( ( -LRB- cord-023095-4dannjjm 538 15 1877 1877 CD cord-023095-4dannjjm 538 16 AE AE NNP cord-023095-4dannjjm 538 17 2081 2081 CD cord-023095-4dannjjm 538 18 pmol pmol NNP cord-023095-4dannjjm 538 19 / / SYM cord-023095-4dannjjm 538 20 L l NN cord-023095-4dannjjm 539 1 ( ( -LRB- cord-023095-4dannjjm 539 2 mean mean VB cord-023095-4dannjjm 539 3 AE AE NNP cord-023095-4dannjjm 539 4 SD SD NNP cord-023095-4dannjjm 539 5 ) ) -RRB- cord-023095-4dannjjm 539 6 , , , cord-023095-4dannjjm 539 7 651 651 CD cord-023095-4dannjjm 539 8 AE AE NNP cord-023095-4dannjjm 539 9 301 301 CD cord-023095-4dannjjm 539 10 ; ; : cord-023095-4dannjjm 539 11 p p NN cord-023095-4dannjjm 539 12 o o CD cord-023095-4dannjjm 539 13 0.0025 0.0025 CD cord-023095-4dannjjm 539 14 ) ) -RRB- cord-023095-4dannjjm 539 15 . . . cord-023095-4dannjjm 540 1 At at IN cord-023095-4dannjjm 540 2 1 1 CD cord-023095-4dannjjm 540 3 day day NN cord-023095-4dannjjm 540 4 and and CC cord-023095-4dannjjm 540 5 3 3 CD cord-023095-4dannjjm 540 6 months month NNS cord-023095-4dannjjm 540 7 following follow VBG cord-023095-4dannjjm 540 8 ductal ductal JJ cord-023095-4dannjjm 540 9 occlusion occlusion NN cord-023095-4dannjjm 540 10 , , , cord-023095-4dannjjm 540 11 NT NT NNP cord-023095-4dannjjm 540 12 - - HYPH cord-023095-4dannjjm 540 13 proBNP proBNP NNP cord-023095-4dannjjm 540 14 was be VBD cord-023095-4dannjjm 540 15 1347 1347 CD cord-023095-4dannjjm 540 16 AE AE NNP cord-023095-4dannjjm 540 17 1256 1256 CD cord-023095-4dannjjm 540 18 and and CC cord-023095-4dannjjm 540 19 466 466 CD cord-023095-4dannjjm 540 20 AE AE NNP cord-023095-4dannjjm 540 21 380 380 CD cord-023095-4dannjjm 540 22 , , , cord-023095-4dannjjm 540 23 respectively respectively RB cord-023095-4dannjjm 540 24 . . . cord-023095-4dannjjm 541 1 The the DT cord-023095-4dannjjm 541 2 following follow VBG cord-023095-4dannjjm 541 3 decreased decrease VBD cord-023095-4dannjjm 541 4 significantly significantly RB cord-023095-4dannjjm 541 5 from from IN cord-023095-4dannjjm 541 6 baseline baseline NN cord-023095-4dannjjm 541 7 : : : cord-023095-4dannjjm 541 8 PCWP PCWP NNP cord-023095-4dannjjm 541 9 ( ( -LRB- cord-023095-4dannjjm 541 10 11.8 11.8 CD cord-023095-4dannjjm 541 11 AE AE NNP cord-023095-4dannjjm 541 12 4.7 4.7 CD cord-023095-4dannjjm 541 13 to to IN cord-023095-4dannjjm 541 14 6.4 6.4 CD cord-023095-4dannjjm 541 15 AE AE NNP cord-023095-4dannjjm 541 16 3.2 3.2 CD cord-023095-4dannjjm 541 17 mmHg mmHg NNS cord-023095-4dannjjm 541 18 ; ; : cord-023095-4dannjjm 541 19 p p NN cord-023095-4dannjjm 541 20 5 5 CD cord-023095-4dannjjm 541 21 0.018 0.018 CD cord-023095-4dannjjm 541 22 ) ) -RRB- cord-023095-4dannjjm 541 23 , , , cord-023095-4dannjjm 541 24 and and CC cord-023095-4dannjjm 541 25 indexed index VBN cord-023095-4dannjjm 541 26 left leave VBN cord-023095-4dannjjm 541 27 ventricular ventricular JJ cord-023095-4dannjjm 541 28 internal internal JJ cord-023095-4dannjjm 541 29 dimensions dimension NNS cord-023095-4dannjjm 541 30 in in IN cord-023095-4dannjjm 541 31 diastole diastole NN cord-023095-4dannjjm 541 32 ( ( -LRB- cord-023095-4dannjjm 541 33 2.26 2.26 CD cord-023095-4dannjjm 541 34 AE AE NNP cord-023095-4dannjjm 541 35 0.47 0.47 CD cord-023095-4dannjjm 541 36 to to IN cord-023095-4dannjjm 541 37 1.67 1.67 CD cord-023095-4dannjjm 541 38 AE AE NNP cord-023095-4dannjjm 541 39 0.19 0.19 CD cord-023095-4dannjjm 541 40 ; ; : cord-023095-4dannjjm 541 41 p p NN cord-023095-4dannjjm 541 42 5 5 CD cord-023095-4dannjjm 541 43 0.006 0.006 CD cord-023095-4dannjjm 541 44 ) ) -RRB- cord-023095-4dannjjm 541 45 but but CC cord-023095-4dannjjm 541 46 not not RB cord-023095-4dannjjm 541 47 significantly significantly RB cord-023095-4dannjjm 541 48 in in IN cord-023095-4dannjjm 541 49 systole systole NN cord-023095-4dannjjm 541 50 ( ( -LRB- cord-023095-4dannjjm 541 51 1.40 1.40 CD cord-023095-4dannjjm 541 52 AE AE NNP cord-023095-4dannjjm 541 53 0.31 0.31 CD cord-023095-4dannjjm 541 54 to to IN cord-023095-4dannjjm 541 55 1.20 1.20 CD cord-023095-4dannjjm 541 56 AE AE NNP cord-023095-4dannjjm 541 57 0.19 0.19 CD cord-023095-4dannjjm 541 58 ; ; : cord-023095-4dannjjm 541 59 p p NN cord-023095-4dannjjm 541 60 5 5 CD cord-023095-4dannjjm 541 61 0.13 0.13 CD cord-023095-4dannjjm 541 62 ) ) -RRB- cord-023095-4dannjjm 541 63 . . . cord-023095-4dannjjm 542 1 NT NT NNP cord-023095-4dannjjm 542 2 - - HYPH cord-023095-4dannjjm 542 3 proBNP proBNP NNP cord-023095-4dannjjm 542 4 is be VBZ cord-023095-4dannjjm 542 5 elevated elevate VBN cord-023095-4dannjjm 542 6 in in IN cord-023095-4dannjjm 542 7 dogs dog NNS cord-023095-4dannjjm 542 8 with with IN cord-023095-4dannjjm 542 9 PDA PDA NNP cord-023095-4dannjjm 542 10 and and CC cord-023095-4dannjjm 542 11 transductal transductal JJ cord-023095-4dannjjm 542 12 closure closure NN cord-023095-4dannjjm 542 13 is be VBZ cord-023095-4dannjjm 542 14 associated associate VBN cord-023095-4dannjjm 542 15 with with IN cord-023095-4dannjjm 542 16 a a DT cord-023095-4dannjjm 542 17 reduction reduction NN cord-023095-4dannjjm 542 18 in in IN cord-023095-4dannjjm 542 19 NT NT NNP cord-023095-4dannjjm 542 20 - - HYPH cord-023095-4dannjjm 542 21 proBNP probnp NN cord-023095-4dannjjm 542 22 , , , cord-023095-4dannjjm 542 23 PCWP PCWP NNP cord-023095-4dannjjm 542 24 and and CC cord-023095-4dannjjm 542 25 left leave VBD cord-023095-4dannjjm 542 26 ventricular ventricular JJ cord-023095-4dannjjm 542 27 size size NN cord-023095-4dannjjm 542 28 . . . cord-023095-4dannjjm 543 1 Cardiac cardiac JJ cord-023095-4dannjjm 543 2 biomarkers biomarker NNS cord-023095-4dannjjm 543 3 , , , cord-023095-4dannjjm 543 4 particularly particularly RB cord-023095-4dannjjm 543 5 NT NT NNP cord-023095-4dannjjm 543 6 - - HYPH cord-023095-4dannjjm 543 7 proBNP probnp NN cord-023095-4dannjjm 543 8 , , , cord-023095-4dannjjm 543 9 are be VBP cord-023095-4dannjjm 543 10 becoming become VBG cord-023095-4dannjjm 543 11 more more RBR cord-023095-4dannjjm 543 12 commonly commonly RB cord-023095-4dannjjm 543 13 used use VBN cord-023095-4dannjjm 543 14 in in IN cord-023095-4dannjjm 543 15 dogs dog NNS cord-023095-4dannjjm 543 16 and and CC cord-023095-4dannjjm 543 17 cats cat NNS cord-023095-4dannjjm 543 18 as as IN cord-023095-4dannjjm 543 19 part part NN cord-023095-4dannjjm 543 20 of of IN cord-023095-4dannjjm 543 21 a a DT cord-023095-4dannjjm 543 22 diagnostic diagnostic JJ cord-023095-4dannjjm 543 23 work work NN cord-023095-4dannjjm 543 24 up up RP cord-023095-4dannjjm 543 25 . . . cord-023095-4dannjjm 544 1 Multiple multiple JJ cord-023095-4dannjjm 544 2 studies study NNS cord-023095-4dannjjm 544 3 already already RB cord-023095-4dannjjm 544 4 have have VBP cord-023095-4dannjjm 544 5 documented document VBN cord-023095-4dannjjm 544 6 the the DT cord-023095-4dannjjm 544 7 correlation correlation NN cord-023095-4dannjjm 544 8 of of IN cord-023095-4dannjjm 544 9 this this DT cord-023095-4dannjjm 544 10 peptide peptide NN cord-023095-4dannjjm 544 11 with with IN cord-023095-4dannjjm 544 12 cardiac cardiac JJ cord-023095-4dannjjm 544 13 disease disease NN cord-023095-4dannjjm 544 14 status status NN cord-023095-4dannjjm 544 15 and and CC cord-023095-4dannjjm 544 16 potential potential JJ cord-023095-4dannjjm 544 17 clinical clinical JJ cord-023095-4dannjjm 544 18 implications implication NNS cord-023095-4dannjjm 544 19 . . . cord-023095-4dannjjm 545 1 In in IN cord-023095-4dannjjm 545 2 a a DT cord-023095-4dannjjm 545 3 portion portion NN cord-023095-4dannjjm 545 4 of of IN cord-023095-4dannjjm 545 5 these these DT cord-023095-4dannjjm 545 6 reports report NNS cord-023095-4dannjjm 545 7 the the DT cord-023095-4dannjjm 545 8 manner manner NN cord-023095-4dannjjm 545 9 in in IN cord-023095-4dannjjm 545 10 which which WDT cord-023095-4dannjjm 545 11 samples sample NNS cord-023095-4dannjjm 545 12 were be VBD cord-023095-4dannjjm 545 13 handled handle VBN cord-023095-4dannjjm 545 14 was be VBD cord-023095-4dannjjm 545 15 placement placement NN cord-023095-4dannjjm 545 16 of of IN cord-023095-4dannjjm 545 17 whole whole JJ cord-023095-4dannjjm 545 18 blood blood NN cord-023095-4dannjjm 545 19 into into IN cord-023095-4dannjjm 545 20 an an DT cord-023095-4dannjjm 545 21 EDTA edta NN cord-023095-4dannjjm 545 22 tube tube NN cord-023095-4dannjjm 545 23 , , , cord-023095-4dannjjm 545 24 followed follow VBN cord-023095-4dannjjm 545 25 by by IN cord-023095-4dannjjm 545 26 centrifugation centrifugation NN cord-023095-4dannjjm 545 27 and and CC cord-023095-4dannjjm 545 28 decanting decanting NN cord-023095-4dannjjm 545 29 of of IN cord-023095-4dannjjm 545 30 the the DT cord-023095-4dannjjm 545 31 supernatant supernatant NN cord-023095-4dannjjm 545 32 that that WDT cord-023095-4dannjjm 545 33 was be VBD cord-023095-4dannjjm 545 34 ultimately ultimately RB cord-023095-4dannjjm 545 35 stored store VBN cord-023095-4dannjjm 545 36 at at IN cord-023095-4dannjjm 545 37 À201C à201c CD cord-023095-4dannjjm 545 38 or or CC cord-023095-4dannjjm 545 39 À801C À801C NNPS cord-023095-4dannjjm 545 40 prior prior RB cord-023095-4dannjjm 545 41 to to IN cord-023095-4dannjjm 545 42 shipment shipment NN cord-023095-4dannjjm 545 43 , , , cord-023095-4dannjjm 545 44 either either CC cord-023095-4dannjjm 545 45 with with IN cord-023095-4dannjjm 545 46 or or CC cord-023095-4dannjjm 545 47 without without IN cord-023095-4dannjjm 545 48 protease protease NN cord-023095-4dannjjm 545 49 inhibition inhibition NN cord-023095-4dannjjm 545 50 . . . cord-023095-4dannjjm 546 1 Our -PRON- PRP$ cord-023095-4dannjjm 546 2 objective objective NN cord-023095-4dannjjm 546 3 was be VBD cord-023095-4dannjjm 546 4 to to TO cord-023095-4dannjjm 546 5 compare compare VB cord-023095-4dannjjm 546 6 the the DT cord-023095-4dannjjm 546 7 NT NT NNP cord-023095-4dannjjm 546 8 - - HYPH cord-023095-4dannjjm 546 9 proBNP probnp NN cord-023095-4dannjjm 546 10 concentrations concentration NNS cord-023095-4dannjjm 546 11 in in IN cord-023095-4dannjjm 546 12 feline feline JJ cord-023095-4dannjjm 546 13 plasma plasma NN cord-023095-4dannjjm 546 14 collected collect VBN cord-023095-4dannjjm 546 15 using use VBG cord-023095-4dannjjm 546 16 the the DT cord-023095-4dannjjm 546 17 previously previously RB cord-023095-4dannjjm 546 18 reported report VBN cord-023095-4dannjjm 546 19 methods method NNS cord-023095-4dannjjm 546 20 to to IN cord-023095-4dannjjm 546 21 the the DT cord-023095-4dannjjm 546 22 California California NNP cord-023095-4dannjjm 546 23 Animal Animal NNP cord-023095-4dannjjm 546 24 Hospital Hospital NNP cord-023095-4dannjjm 546 25 ( ( -LRB- cord-023095-4dannjjm 546 26 CAH CAH NNP cord-023095-4dannjjm 546 27 ) ) -RRB- cord-023095-4dannjjm 546 28 collection collection NN cord-023095-4dannjjm 546 29 method method NN cord-023095-4dannjjm 546 30 using use VBG cord-023095-4dannjjm 546 31 tubes tube NNS cord-023095-4dannjjm 546 32 containing contain VBG cord-023095-4dannjjm 546 33 a a DT cord-023095-4dannjjm 546 34 protease protease NN cord-023095-4dannjjm 546 35 inhibitor inhibitor NN cord-023095-4dannjjm 546 36 . . . cord-023095-4dannjjm 547 1 This this DT cord-023095-4dannjjm 547 2 study study NN cord-023095-4dannjjm 547 3 compared compare VBD cord-023095-4dannjjm 547 4 NT NT NNP cord-023095-4dannjjm 547 5 - - HYPH cord-023095-4dannjjm 547 6 proBNP probnp NN cord-023095-4dannjjm 547 7 concentrations concentration NNS cord-023095-4dannjjm 547 8 using use VBG cord-023095-4dannjjm 547 9 the the DT cord-023095-4dannjjm 547 10 protease protease NN cord-023095-4dannjjm 547 11 inhibitor inhibitor NN cord-023095-4dannjjm 547 12 tubes tube NNS cord-023095-4dannjjm 547 13 vs. vs. IN cord-023095-4dannjjm 547 14 EDTA edta NN cord-023095-4dannjjm 547 15 tubes tube NNS cord-023095-4dannjjm 547 16 from from IN cord-023095-4dannjjm 547 17 18 18 CD cord-023095-4dannjjm 547 18 privately privately RB cord-023095-4dannjjm 547 19 owned own VBN cord-023095-4dannjjm 547 20 feline feline JJ cord-023095-4dannjjm 547 21 patients patient NNS cord-023095-4dannjjm 547 22 , , , cord-023095-4dannjjm 547 23 with with IN cord-023095-4dannjjm 547 24 confirmed confirm VBN cord-023095-4dannjjm 547 25 cardiac cardiac JJ cord-023095-4dannjjm 547 26 disease disease NN cord-023095-4dannjjm 547 27 , , , cord-023095-4dannjjm 547 28 and and CC cord-023095-4dannjjm 547 29 6 6 CD cord-023095-4dannjjm 547 30 control control NN cord-023095-4dannjjm 547 31 feline feline JJ cord-023095-4dannjjm 547 32 patients patient NNS cord-023095-4dannjjm 547 33 . . . cord-023095-4dannjjm 548 1 For for IN cord-023095-4dannjjm 548 2 all all DT cord-023095-4dannjjm 548 3 study study NN cord-023095-4dannjjm 548 4 participants participant NNS cord-023095-4dannjjm 548 5 , , , cord-023095-4dannjjm 548 6 we -PRON- PRP cord-023095-4dannjjm 548 7 performed perform VBD cord-023095-4dannjjm 548 8 a a DT cord-023095-4dannjjm 548 9 full full JJ cord-023095-4dannjjm 548 10 history history NN cord-023095-4dannjjm 548 11 and and CC cord-023095-4dannjjm 548 12 physical physical JJ cord-023095-4dannjjm 548 13 examination examination NN cord-023095-4dannjjm 548 14 , , , cord-023095-4dannjjm 548 15 a a DT cord-023095-4dannjjm 548 16 hematology hematology NN cord-023095-4dannjjm 548 17 and and CC cord-023095-4dannjjm 548 18 chemistry chemistry NN cord-023095-4dannjjm 548 19 panel panel NN cord-023095-4dannjjm 548 20 , , , cord-023095-4dannjjm 548 21 thoracic thoracic JJ cord-023095-4dannjjm 548 22 radiographs radiograph NNS cord-023095-4dannjjm 548 23 , , , cord-023095-4dannjjm 548 24 ECG ECG NNP cord-023095-4dannjjm 548 25 , , , cord-023095-4dannjjm 548 26 and and CC cord-023095-4dannjjm 548 27 echocardiogram echocardiogram NN cord-023095-4dannjjm 548 28 . . . cord-023095-4dannjjm 549 1 In in IN cord-023095-4dannjjm 549 2 each each DT cord-023095-4dannjjm 549 3 study study NN cord-023095-4dannjjm 549 4 participant participant NN cord-023095-4dannjjm 549 5 , , , cord-023095-4dannjjm 549 6 at at IN cord-023095-4dannjjm 549 7 least least JJS cord-023095-4dannjjm 549 8 4 4 CD cord-023095-4dannjjm 549 9 ml ml NN cord-023095-4dannjjm 549 10 's 's POS cord-023095-4dannjjm 549 11 of of IN cord-023095-4dannjjm 549 12 whole whole JJ cord-023095-4dannjjm 549 13 blood blood NN cord-023095-4dannjjm 549 14 was be VBD cord-023095-4dannjjm 549 15 drawn draw VBN cord-023095-4dannjjm 549 16 from from IN cord-023095-4dannjjm 549 17 a a DT cord-023095-4dannjjm 549 18 peripheral peripheral JJ cord-023095-4dannjjm 549 19 vein vein NN cord-023095-4dannjjm 549 20 , , , cord-023095-4dannjjm 549 21 and and CC cord-023095-4dannjjm 549 22 transferred transfer VBN cord-023095-4dannjjm 549 23 to to IN cord-023095-4dannjjm 549 24 a a DT cord-023095-4dannjjm 549 25 plastic plastic JJ cord-023095-4dannjjm 549 26 EDTA edta NN cord-023095-4dannjjm 549 27 tube tube NN cord-023095-4dannjjm 549 28 . . . cord-023095-4dannjjm 550 1 The the DT cord-023095-4dannjjm 550 2 sample sample NN cord-023095-4dannjjm 550 3 was be VBD cord-023095-4dannjjm 550 4 centrifuged centrifuge VBN cord-023095-4dannjjm 550 5 within within IN cord-023095-4dannjjm 550 6 1 1 CD cord-023095-4dannjjm 550 7 hour hour NN cord-023095-4dannjjm 550 8 after after IN cord-023095-4dannjjm 550 9 collection collection NN cord-023095-4dannjjm 550 10 . . . cord-023095-4dannjjm 551 1 1 1 CD cord-023095-4dannjjm 551 2 ml ml NNS cord-023095-4dannjjm 551 3 of of IN cord-023095-4dannjjm 551 4 plasma plasma NN cord-023095-4dannjjm 551 5 was be VBD cord-023095-4dannjjm 551 6 then then RB cord-023095-4dannjjm 551 7 transferred transfer VBN cord-023095-4dannjjm 551 8 to to IN cord-023095-4dannjjm 551 9 a a DT cord-023095-4dannjjm 551 10 tube tube NN cord-023095-4dannjjm 551 11 containing contain VBG cord-023095-4dannjjm 551 12 a a DT cord-023095-4dannjjm 551 13 protease protease NN cord-023095-4dannjjm 551 14 inhibitor inhibitor NN cord-023095-4dannjjm 551 15 , , , cord-023095-4dannjjm 551 16 which which WDT cord-023095-4dannjjm 551 17 was be VBD cord-023095-4dannjjm 551 18 stored store VBN cord-023095-4dannjjm 551 19 at at IN cord-023095-4dannjjm 551 20 41C 41c CD cord-023095-4dannjjm 551 21 until until IN cord-023095-4dannjjm 551 22 being be VBG cord-023095-4dannjjm 551 23 shipped ship VBN cord-023095-4dannjjm 551 24 within within IN cord-023095-4dannjjm 551 25 24 24 CD cord-023095-4dannjjm 551 26 hours hour NNS cord-023095-4dannjjm 551 27 of of IN cord-023095-4dannjjm 551 28 collection collection NN cord-023095-4dannjjm 551 29 . . . cord-023095-4dannjjm 552 1 The the DT cord-023095-4dannjjm 552 2 remaining remain VBG cord-023095-4dannjjm 552 3 plasma plasma NN cord-023095-4dannjjm 552 4 was be VBD cord-023095-4dannjjm 552 5 placed place VBN cord-023095-4dannjjm 552 6 into into IN cord-023095-4dannjjm 552 7 2 2 CD cord-023095-4dannjjm 552 8 separate separate JJ cord-023095-4dannjjm 552 9 microtubes microtube NNS cord-023095-4dannjjm 552 10 , , , cord-023095-4dannjjm 552 11 which which WDT cord-023095-4dannjjm 552 12 did do VBD cord-023095-4dannjjm 552 13 not not RB cord-023095-4dannjjm 552 14 contain contain VB cord-023095-4dannjjm 552 15 a a DT cord-023095-4dannjjm 552 16 protease protease NN cord-023095-4dannjjm 552 17 inhibitor inhibitor NN cord-023095-4dannjjm 552 18 . . . cord-023095-4dannjjm 553 1 One one CD cord-023095-4dannjjm 553 2 microtube microtube NN cord-023095-4dannjjm 553 3 was be VBD cord-023095-4dannjjm 553 4 then then RB cord-023095-4dannjjm 553 5 stored store VBN cord-023095-4dannjjm 553 6 and and CC cord-023095-4dannjjm 553 7 shipped ship VBN cord-023095-4dannjjm 553 8 as as IN cord-023095-4dannjjm 553 9 previous previous JJ cord-023095-4dannjjm 553 10 studies study NNS cord-023095-4dannjjm 553 11 have have VBP cord-023095-4dannjjm 553 12 reported report VBN cord-023095-4dannjjm 553 13 ( ( -LRB- cord-023095-4dannjjm 553 14 À201C À201C NNPS cord-023095-4dannjjm 553 15 , , , cord-023095-4dannjjm 553 16 Styrofoam Styrofoam NNP cord-023095-4dannjjm 553 17 container container NN cord-023095-4dannjjm 553 18 , , , cord-023095-4dannjjm 553 19 shipment shipment NN cord-023095-4dannjjm 553 20 within within IN cord-023095-4dannjjm 553 21 24 24 CD cord-023095-4dannjjm 553 22 hours hour NNS cord-023095-4dannjjm 553 23 ) ) -RRB- cord-023095-4dannjjm 553 24 , , , cord-023095-4dannjjm 553 25 and and CC cord-023095-4dannjjm 553 26 the the DT cord-023095-4dannjjm 553 27 second second JJ cord-023095-4dannjjm 553 28 microtube microtube NN cord-023095-4dannjjm 553 29 was be VBD cord-023095-4dannjjm 553 30 frozen freeze VBN cord-023095-4dannjjm 553 31 at at IN cord-023095-4dannjjm 553 32 À801C. à801c. CD cord-023095-4dannjjm 554 1 All all DT cord-023095-4dannjjm 554 2 samples sample NNS cord-023095-4dannjjm 554 3 were be VBD cord-023095-4dannjjm 554 4 shipped ship VBN cord-023095-4dannjjm 554 5 , , , cord-023095-4dannjjm 554 6 received receive VBN cord-023095-4dannjjm 554 7 and and CC cord-023095-4dannjjm 554 8 analyzed analyze VBN cord-023095-4dannjjm 554 9 within within IN cord-023095-4dannjjm 554 10 24 24 CD cord-023095-4dannjjm 554 11 hours hour NNS cord-023095-4dannjjm 554 12 of of IN cord-023095-4dannjjm 554 13 collection collection NN cord-023095-4dannjjm 554 14 . . . cord-023095-4dannjjm 555 1 Results result NNS cord-023095-4dannjjm 555 2 of of IN cord-023095-4dannjjm 555 3 this this DT cord-023095-4dannjjm 555 4 study study NN cord-023095-4dannjjm 555 5 showed show VBD cord-023095-4dannjjm 555 6 that that IN cord-023095-4dannjjm 555 7 no no DT cord-023095-4dannjjm 555 8 difference difference NN cord-023095-4dannjjm 555 9 was be VBD cord-023095-4dannjjm 555 10 found find VBN cord-023095-4dannjjm 555 11 between between IN cord-023095-4dannjjm 555 12 the the DT cord-023095-4dannjjm 555 13 2 2 CD cord-023095-4dannjjm 555 14 frozen frozen JJ cord-023095-4dannjjm 555 15 sample sample NN cord-023095-4dannjjm 555 16 methods method NNS cord-023095-4dannjjm 555 17 ( ( -LRB- cord-023095-4dannjjm 555 18 663 663 CD cord-023095-4dannjjm 555 19 pmol pmol NN cord-023095-4dannjjm 555 20 / / SYM cord-023095-4dannjjm 555 21 L l NN cord-023095-4dannjjm 555 22 and and CC cord-023095-4dannjjm 555 23 650 650 CD cord-023095-4dannjjm 555 24 pmol pmol NN cord-023095-4dannjjm 555 25 / / SYM cord-023095-4dannjjm 555 26 L l NN cord-023095-4dannjjm 555 27 p p NN cord-023095-4dannjjm 555 28 5 5 CD cord-023095-4dannjjm 555 29 0.40 0.40 CD cord-023095-4dannjjm 555 30 ) ) -RRB- cord-023095-4dannjjm 555 31 . . . cord-023095-4dannjjm 556 1 It -PRON- PRP cord-023095-4dannjjm 556 2 was be VBD cord-023095-4dannjjm 556 3 determined determine VBN cord-023095-4dannjjm 556 4 that that IN cord-023095-4dannjjm 556 5 both both DT cord-023095-4dannjjm 556 6 frozen frozen JJ cord-023095-4dannjjm 556 7 methods method NNS cord-023095-4dannjjm 556 8 had have VBD cord-023095-4dannjjm 556 9 lower low JJR cord-023095-4dannjjm 556 10 NT NT NNP cord-023095-4dannjjm 556 11 - - HYPH cord-023095-4dannjjm 556 12 proBNP probnp NN cord-023095-4dannjjm 556 13 levels level NNS cord-023095-4dannjjm 556 14 ( ( -LRB- cord-023095-4dannjjm 556 15 655 655 CD cord-023095-4dannjjm 556 16 and and CC cord-023095-4dannjjm 556 17 646 646 CD cord-023095-4dannjjm 556 18 pmol pmol NNP cord-023095-4dannjjm 556 19 / / SYM cord-023095-4dannjjm 556 20 L L NNP cord-023095-4dannjjm 556 21 ) ) -RRB- cord-023095-4dannjjm 556 22 when when WRB cord-023095-4dannjjm 556 23 compared compare VBN cord-023095-4dannjjm 556 24 to to IN cord-023095-4dannjjm 556 25 plasma plasma NN cord-023095-4dannjjm 556 26 samples sample NNS cord-023095-4dannjjm 556 27 shipped ship VBN cord-023095-4dannjjm 556 28 in in IN cord-023095-4dannjjm 556 29 protease protease JJ cord-023095-4dannjjm 556 30 inhibitor inhibitor NN cord-023095-4dannjjm 556 31 tubes tube NNS cord-023095-4dannjjm 556 32 ( ( -LRB- cord-023095-4dannjjm 556 33 756 756 CD cord-023095-4dannjjm 556 34 and and CC cord-023095-4dannjjm 556 35 794 794 CD cord-023095-4dannjjm 556 36 pmol pmol NNP cord-023095-4dannjjm 556 37 / / SYM cord-023095-4dannjjm 556 38 L L NNP cord-023095-4dannjjm 556 39 ) ) -RRB- cord-023095-4dannjjm 556 40 . . . cord-023095-4dannjjm 557 1 The the DT cord-023095-4dannjjm 557 2 findings finding NNS cord-023095-4dannjjm 557 3 of of IN cord-023095-4dannjjm 557 4 this this DT cord-023095-4dannjjm 557 5 trial trial NN cord-023095-4dannjjm 557 6 demonstrate demonstrate VBP cord-023095-4dannjjm 557 7 that that IN cord-023095-4dannjjm 557 8 the the DT cord-023095-4dannjjm 557 9 NT NT NNP cord-023095-4dannjjm 557 10 - - HYPH cord-023095-4dannjjm 557 11 proBNP probnp NN cord-023095-4dannjjm 557 12 levels level NNS cord-023095-4dannjjm 557 13 are be VBP cord-023095-4dannjjm 557 14 significantly significantly RB cord-023095-4dannjjm 557 15 different different JJ cord-023095-4dannjjm 557 16 between between IN cord-023095-4dannjjm 557 17 samples sample NNS cord-023095-4dannjjm 557 18 placed place VBN cord-023095-4dannjjm 557 19 in in IN cord-023095-4dannjjm 557 20 EDTA EDTA NNP cord-023095-4dannjjm 557 21 tubes tube NNS cord-023095-4dannjjm 557 22 vs. vs. IN cord-023095-4dannjjm 557 23 contain contain VBP cord-023095-4dannjjm 557 24 protease protease NN cord-023095-4dannjjm 557 25 inhibitor inhibitor NN cord-023095-4dannjjm 557 26 ( ( -LRB- cord-023095-4dannjjm 557 27 p p NN cord-023095-4dannjjm 557 28 5 5 CD cord-023095-4dannjjm 557 29 0.008 0.008 CD cord-023095-4dannjjm 557 30 and and CC cord-023095-4dannjjm 557 31 p p NN cord-023095-4dannjjm 557 32 5 5 CD cord-023095-4dannjjm 557 33 0.0006 0.0006 CD cord-023095-4dannjjm 557 34 ) ) -RRB- cord-023095-4dannjjm 557 35 . . . cord-023095-4dannjjm 558 1 Utilizing utilize VBG cord-023095-4dannjjm 558 2 protease protease NN cord-023095-4dannjjm 558 3 inhibitor inhibitor NN cord-023095-4dannjjm 558 4 tubes tube NNS cord-023095-4dannjjm 558 5 allows allow VBZ cord-023095-4dannjjm 558 6 more more RBR cord-023095-4dannjjm 558 7 accurate accurate JJ cord-023095-4dannjjm 558 8 measurement measurement NN cord-023095-4dannjjm 558 9 of of IN cord-023095-4dannjjm 558 10 plasma plasma NN cord-023095-4dannjjm 558 11 NT NT NNP cord-023095-4dannjjm 558 12 - - HYPH cord-023095-4dannjjm 558 13 proBNP probnp NN cord-023095-4dannjjm 558 14 . . . cord-023095-4dannjjm 559 1 As as IN cord-023095-4dannjjm 559 2 for for IN cord-023095-4dannjjm 559 3 its -PRON- PRP$ cord-023095-4dannjjm 559 4 relevance relevance NN cord-023095-4dannjjm 559 5 for for IN cord-023095-4dannjjm 559 6 future future JJ cord-023095-4dannjjm 559 7 research research NN cord-023095-4dannjjm 559 8 and and CC cord-023095-4dannjjm 559 9 publications publication NNS cord-023095-4dannjjm 559 10 , , , cord-023095-4dannjjm 559 11 authors author NNS cord-023095-4dannjjm 559 12 should should MD cord-023095-4dannjjm 559 13 take take VB cord-023095-4dannjjm 559 14 care care NN cord-023095-4dannjjm 559 15 to to TO cord-023095-4dannjjm 559 16 investigate investigate VB cord-023095-4dannjjm 559 17 the the DT cord-023095-4dannjjm 559 18 manner manner NN cord-023095-4dannjjm 559 19 in in IN cord-023095-4dannjjm 559 20 which which WDT cord-023095-4dannjjm 559 21 blood blood NN cord-023095-4dannjjm 559 22 samples sample NNS cord-023095-4dannjjm 559 23 were be VBD cord-023095-4dannjjm 559 24 handled handle VBN cord-023095-4dannjjm 559 25 and and CC cord-023095-4dannjjm 559 26 the the DT cord-023095-4dannjjm 559 27 conclusion conclusion NN cord-023095-4dannjjm 559 28 / / SYM cord-023095-4dannjjm 559 29 results result NNS cord-023095-4dannjjm 559 30 of of IN cord-023095-4dannjjm 559 31 these these DT cord-023095-4dannjjm 559 32 studies study NNS cord-023095-4dannjjm 559 33 should should MD cord-023095-4dannjjm 559 34 be be VB cord-023095-4dannjjm 559 35 taken take VBN cord-023095-4dannjjm 559 36 in in IN cord-023095-4dannjjm 559 37 light light NN cord-023095-4dannjjm 559 38 of of IN cord-023095-4dannjjm 559 39 the the DT cord-023095-4dannjjm 559 40 methodologies methodology NNS cord-023095-4dannjjm 559 41 used use VBN cord-023095-4dannjjm 559 42 in in IN cord-023095-4dannjjm 559 43 collecting collect VBG cord-023095-4dannjjm 559 44 , , , cord-023095-4dannjjm 559 45 storing store VBG cord-023095-4dannjjm 559 46 , , , cord-023095-4dannjjm 559 47 shipping ship VBG cord-023095-4dannjjm 559 48 and and CC cord-023095-4dannjjm 559 49 analyzing analyze VBG cord-023095-4dannjjm 559 50 the the DT cord-023095-4dannjjm 559 51 samples sample NNS cord-023095-4dannjjm 559 52 . . . cord-023095-4dannjjm 560 1 Degenerative degenerative JJ cord-023095-4dannjjm 560 2 mitral mitral JJ cord-023095-4dannjjm 560 3 valve valve NN cord-023095-4dannjjm 560 4 disease disease NN cord-023095-4dannjjm 560 5 ( ( -LRB- cord-023095-4dannjjm 560 6 DMVD DMVD NNP cord-023095-4dannjjm 560 7 ) ) -RRB- cord-023095-4dannjjm 560 8 is be VBZ cord-023095-4dannjjm 560 9 one one CD cord-023095-4dannjjm 560 10 of of IN cord-023095-4dannjjm 560 11 the the DT cord-023095-4dannjjm 560 12 most most RBS cord-023095-4dannjjm 560 13 common common JJ cord-023095-4dannjjm 560 14 heart heart NN cord-023095-4dannjjm 560 15 disease disease NN cord-023095-4dannjjm 560 16 and and CC cord-023095-4dannjjm 560 17 is be VBZ cord-023095-4dannjjm 560 18 present present JJ cord-023095-4dannjjm 560 19 approximately approximately RB cord-023095-4dannjjm 560 20 75 75 CD cord-023095-4dannjjm 560 21 % % NN cord-023095-4dannjjm 560 22 of of IN cord-023095-4dannjjm 560 23 the the DT cord-023095-4dannjjm 560 24 canine canine JJ cord-023095-4dannjjm 560 25 heart heart NN cord-023095-4dannjjm 560 26 disease disease NN cord-023095-4dannjjm 560 27 . . . cord-023095-4dannjjm 561 1 Although although IN cord-023095-4dannjjm 561 2 the the DT cord-023095-4dannjjm 561 3 high high JJ cord-023095-4dannjjm 561 4 prevalence prevalence NN cord-023095-4dannjjm 561 5 exists exist VBZ cord-023095-4dannjjm 561 6 in in IN cord-023095-4dannjjm 561 7 small small JJ cord-023095-4dannjjm 561 8 dogs dog NNS cord-023095-4dannjjm 561 9 , , , cord-023095-4dannjjm 561 10 the the DT cord-023095-4dannjjm 561 11 underlying underlying JJ cord-023095-4dannjjm 561 12 molecular molecular JJ cord-023095-4dannjjm 561 13 mechanism mechanism NN cord-023095-4dannjjm 561 14 of of IN cord-023095-4dannjjm 561 15 its -PRON- PRP$ cord-023095-4dannjjm 561 16 pathophysiology pathophysiology NN cord-023095-4dannjjm 561 17 is be VBZ cord-023095-4dannjjm 561 18 rarely rarely RB cord-023095-4dannjjm 561 19 known know VBN cord-023095-4dannjjm 561 20 . . . cord-023095-4dannjjm 562 1 DMVD DMVD NNP cord-023095-4dannjjm 562 2 is be VBZ cord-023095-4dannjjm 562 3 functionally functionally RB cord-023095-4dannjjm 562 4 and and CC cord-023095-4dannjjm 562 5 pathologically pathologically RB cord-023095-4dannjjm 562 6 similar similar JJ cord-023095-4dannjjm 562 7 in in IN cord-023095-4dannjjm 562 8 humans human NNS cord-023095-4dannjjm 562 9 and and CC cord-023095-4dannjjm 562 10 dogs dog NNS cord-023095-4dannjjm 562 11 , , , cord-023095-4dannjjm 562 12 thus thus RB cord-023095-4dannjjm 562 13 , , , cord-023095-4dannjjm 562 14 there there EX cord-023095-4dannjjm 562 15 will will MD cord-023095-4dannjjm 562 16 be be VB cord-023095-4dannjjm 562 17 a a DT cord-023095-4dannjjm 562 18 common common JJ cord-023095-4dannjjm 562 19 pathogenesis pathogenesis NN cord-023095-4dannjjm 562 20 in in IN cord-023095-4dannjjm 562 21 human human NN cord-023095-4dannjjm 562 22 and and CC cord-023095-4dannjjm 562 23 dogs dog NNS cord-023095-4dannjjm 562 24 with with IN cord-023095-4dannjjm 562 25 naturally naturally RB cord-023095-4dannjjm 562 26 occurring occur VBG cord-023095-4dannjjm 562 27 DMVD DMVD NNS cord-023095-4dannjjm 562 28 . . . cord-023095-4dannjjm 563 1 Serotonin serotonin NN cord-023095-4dannjjm 563 2 and and CC cord-023095-4dannjjm 563 3 serotonin serotonin NN cord-023095-4dannjjm 563 4 - - HYPH cord-023095-4dannjjm 563 5 related relate VBN cord-023095-4dannjjm 563 6 mechanisms mechanism NNS cord-023095-4dannjjm 563 7 have have VBP cord-023095-4dannjjm 563 8 been be VBN cord-023095-4dannjjm 563 9 implicated implicate VBN cord-023095-4dannjjm 563 10 as as IN cord-023095-4dannjjm 563 11 a a DT cord-023095-4dannjjm 563 12 cause cause NN cord-023095-4dannjjm 563 13 of of IN cord-023095-4dannjjm 563 14 valvular valvular JJ cord-023095-4dannjjm 563 15 disease disease NN cord-023095-4dannjjm 563 16 in in IN cord-023095-4dannjjm 563 17 human human NN cord-023095-4dannjjm 563 18 and and CC cord-023095-4dannjjm 563 19 animals animal NNS cord-023095-4dannjjm 563 20 , , , cord-023095-4dannjjm 563 21 including include VBG cord-023095-4dannjjm 563 22 spontaneous spontaneous JJ cord-023095-4dannjjm 563 23 DMVD DMVD NNS cord-023095-4dannjjm 563 24 in in IN cord-023095-4dannjjm 563 25 dogs dog NNS cord-023095-4dannjjm 563 26 . . . cord-023095-4dannjjm 564 1 Increased increase VBN cord-023095-4dannjjm 564 2 circulating circulate VBG cord-023095-4dannjjm 564 3 5HT 5ht NN cord-023095-4dannjjm 564 4 concentration concentration NN cord-023095-4dannjjm 564 5 as as IN cord-023095-4dannjjm 564 6 a a DT cord-023095-4dannjjm 564 7 potential potential JJ cord-023095-4dannjjm 564 8 source source NN cord-023095-4dannjjm 564 9 of of IN cord-023095-4dannjjm 564 10 heightened heighten VBN cord-023095-4dannjjm 564 11 5HT 5ht NN cord-023095-4dannjjm 564 12 signaling signaling NN cord-023095-4dannjjm 564 13 is be VBZ cord-023095-4dannjjm 564 14 demonstrated demonstrate VBN cord-023095-4dannjjm 564 15 in in IN cord-023095-4dannjjm 564 16 small small JJ cord-023095-4dannjjm 564 17 dogs dog NNS cord-023095-4dannjjm 564 18 with with IN cord-023095-4dannjjm 564 19 DMVD DMVD NNS cord-023095-4dannjjm 564 20 . . . cord-023095-4dannjjm 565 1 The the DT cord-023095-4dannjjm 565 2 aim aim NN cord-023095-4dannjjm 565 3 of of IN cord-023095-4dannjjm 565 4 this this DT cord-023095-4dannjjm 565 5 study study NN cord-023095-4dannjjm 565 6 was be VBD cord-023095-4dannjjm 565 7 to to TO cord-023095-4dannjjm 565 8 investigate investigate VB cord-023095-4dannjjm 565 9 whether whether IN cord-023095-4dannjjm 565 10 serum serum NN cord-023095-4dannjjm 565 11 5HT 5ht NN cord-023095-4dannjjm 565 12 concentrations concentration NNS cord-023095-4dannjjm 565 13 were be VBD cord-023095-4dannjjm 565 14 associated associate VBN cord-023095-4dannjjm 565 15 with with IN cord-023095-4dannjjm 565 16 severity severity NN cord-023095-4dannjjm 565 17 of of IN cord-023095-4dannjjm 565 18 naturally naturally RB cord-023095-4dannjjm 565 19 occurring occur VBG cord-023095-4dannjjm 565 20 DMVD DMVD NNP cord-023095-4dannjjm 565 21 in in IN cord-023095-4dannjjm 565 22 small small JJ cord-023095-4dannjjm 565 23 dogs dog NNS cord-023095-4dannjjm 565 24 and and CC cord-023095-4dannjjm 565 25 to to TO cord-023095-4dannjjm 565 26 investigate investigate VB cord-023095-4dannjjm 565 27 potential potential JJ cord-023095-4dannjjm 565 28 associations association NNS cord-023095-4dannjjm 565 29 of of IN cord-023095-4dannjjm 565 30 dog dog NN cord-023095-4dannjjm 565 31 characteristics characteristic NNS cord-023095-4dannjjm 565 32 on on IN cord-023095-4dannjjm 565 33 serum serum NN cord-023095-4dannjjm 565 34 5HT 5ht NN cord-023095-4dannjjm 565 35 concentrations concentration NNS cord-023095-4dannjjm 565 36 in in IN cord-023095-4dannjjm 565 37 our -PRON- PRP$ cord-023095-4dannjjm 565 38 study study NN cord-023095-4dannjjm 565 39 population population NN cord-023095-4dannjjm 565 40 . . . cord-023095-4dannjjm 566 1 Forty forty CD cord-023095-4dannjjm 566 2 - - HYPH cord-023095-4dannjjm 566 3 eight eight CD cord-023095-4dannjjm 566 4 dogs dog NNS cord-023095-4dannjjm 566 5 were be VBD cord-023095-4dannjjm 566 6 included include VBN cord-023095-4dannjjm 566 7 in in IN cord-023095-4dannjjm 566 8 this this DT cord-023095-4dannjjm 566 9 study study NN cord-023095-4dannjjm 566 10 and and CC cord-023095-4dannjjm 566 11 were be VBD cord-023095-4dannjjm 566 12 classified classify VBN cord-023095-4dannjjm 566 13 into into IN cord-023095-4dannjjm 566 14 control control NN cord-023095-4dannjjm 566 15 and and CC cord-023095-4dannjjm 566 16 DMVD DMVD NNP cord-023095-4dannjjm 566 17 groups group NNS cord-023095-4dannjjm 566 18 according accord VBG cord-023095-4dannjjm 566 19 to to IN cord-023095-4dannjjm 566 20 the the DT cord-023095-4dannjjm 566 21 results result NNS cord-023095-4dannjjm 566 22 of of IN cord-023095-4dannjjm 566 23 physical physical JJ cord-023095-4dannjjm 566 24 and and CC cord-023095-4dannjjm 566 25 echocardiographic echocardiographic JJ cord-023095-4dannjjm 566 26 examinations examination NNS cord-023095-4dannjjm 566 27 . . . cord-023095-4dannjjm 567 1 Based base VBN cord-023095-4dannjjm 567 2 on on IN cord-023095-4dannjjm 567 3 the the DT cord-023095-4dannjjm 567 4 LA la NN cord-023095-4dannjjm 567 5 : : : cord-023095-4dannjjm 567 6 Ao Ao NNP cord-023095-4dannjjm 567 7 ratio ratio NN cord-023095-4dannjjm 567 8 , , , cord-023095-4dannjjm 567 9 dogs dog NNS cord-023095-4dannjjm 567 10 with with IN cord-023095-4dannjjm 567 11 DMVD DMVD NNP cord-023095-4dannjjm 567 12 were be VBD cord-023095-4dannjjm 567 13 classified classify VBN cord-023095-4dannjjm 567 14 as as IN cord-023095-4dannjjm 567 15 follow follow NN cord-023095-4dannjjm 567 16 : : : cord-023095-4dannjjm 568 1 Control Control NNP cord-023095-4dannjjm 568 2 ( ( -LRB- cord-023095-4dannjjm 568 3 LA LA NNP cord-023095-4dannjjm 568 4 : : : cord-023095-4dannjjm 569 1 Ao Ao NNP cord-023095-4dannjjm 569 2 ratio ratio NN cord-023095-4dannjjm 569 3 1.5 1.5 CD cord-023095-4dannjjm 569 4 and and CC cord-023095-4dannjjm 569 5 no no DT cord-023095-4dannjjm 569 6 MR MR NNP cord-023095-4dannjjm 569 7 ) ) -RRB- cord-023095-4dannjjm 569 8 , , . cord-023095-4dannjjm 570 1 mild mild JJ cord-023095-4dannjjm 570 2 ( ( -LRB- cord-023095-4dannjjm 570 3 LA LA NNP cord-023095-4dannjjm 570 4 : : : cord-023095-4dannjjm 571 1 Ao Ao NNP cord-023095-4dannjjm 571 2 ratio ratio NN cord-023095-4dannjjm 571 3 1.5 1.5 CD cord-023095-4dannjjm 571 4 and and CC cord-023095-4dannjjm 571 5 MR MR NNP cord-023095-4dannjjm 571 6 ) ) -RRB- cord-023095-4dannjjm 571 7 , , . cord-023095-4dannjjm 572 1 moderate moderate JJ cord-023095-4dannjjm 572 2 ( ( -LRB- cord-023095-4dannjjm 572 3 1.5 1.5 CD cord-023095-4dannjjm 572 4 o o NN cord-023095-4dannjjm 572 5 LA la NN cord-023095-4dannjjm 572 6 : : : cord-023095-4dannjjm 573 1 Ao ao NN cord-023095-4dannjjm 573 2 ratio ratio NN cord-023095-4dannjjm 573 3 1.8 1.8 CD cord-023095-4dannjjm 573 4 and and CC cord-023095-4dannjjm 573 5 MR MR NNP cord-023095-4dannjjm 573 6 ) ) -RRB- cord-023095-4dannjjm 573 7 , , . cord-023095-4dannjjm 574 1 Severe severe JJ cord-023095-4dannjjm 574 2 ( ( -LRB- cord-023095-4dannjjm 574 3 LA la NN cord-023095-4dannjjm 574 4 : : : cord-023095-4dannjjm 575 1 Ao ao NN cord-023095-4dannjjm 575 2 ratio ratio NN cord-023095-4dannjjm 575 3 41.8 41.8 CD cord-023095-4dannjjm 575 4 and and CC cord-023095-4dannjjm 575 5 MR MR NNP cord-023095-4dannjjm 575 6 ) ) -RRB- cord-023095-4dannjjm 575 7 . . . cord-023095-4dannjjm 576 1 Serum serum NN cord-023095-4dannjjm 576 2 serotonin serotonin NN cord-023095-4dannjjm 576 3 concentrations concentration NNS cord-023095-4dannjjm 576 4 were be VBD cord-023095-4dannjjm 576 5 measured measure VBN cord-023095-4dannjjm 576 6 by by IN cord-023095-4dannjjm 576 7 ELISA ELISA NNP cord-023095-4dannjjm 576 8 . . . cord-023095-4dannjjm 577 1 An an DT cord-023095-4dannjjm 577 2 overall overall JJ cord-023095-4dannjjm 577 3 significant significant JJ cord-023095-4dannjjm 577 4 difference difference NN cord-023095-4dannjjm 577 5 ( ( -LRB- cord-023095-4dannjjm 577 6 P p NN cord-023095-4dannjjm 577 7 o o NN cord-023095-4dannjjm 577 8 .05 .05 NFP cord-023095-4dannjjm 577 9 ) ) -RRB- cord-023095-4dannjjm 577 10 was be VBD cord-023095-4dannjjm 577 11 found find VBN cord-023095-4dannjjm 577 12 among among IN cord-023095-4dannjjm 577 13 4 4 CD cord-023095-4dannjjm 577 14 groups group NNS cord-023095-4dannjjm 577 15 and and CC cord-023095-4dannjjm 577 16 5HT 5ht NN cord-023095-4dannjjm 577 17 concentrations concentration NNS cord-023095-4dannjjm 577 18 ( ( -LRB- cord-023095-4dannjjm 577 19 control control NN cord-023095-4dannjjm 577 20 , , , cord-023095-4dannjjm 577 21 72.38 72.38 CD cord-023095-4dannjjm 577 22 ng ng NN cord-023095-4dannjjm 577 23 / / SYM cord-023095-4dannjjm 577 24 ml ml NNP cord-023095-4dannjjm 577 25 [ [ -LRB- cord-023095-4dannjjm 577 26 51.34 51.34 CD cord-023095-4dannjjm 577 27 - - HYPH cord-023095-4dannjjm 577 28 95.11 95.11 CD cord-023095-4dannjjm 577 29 DMVD DMVD NNS cord-023095-4dannjjm 577 30 , , , cord-023095-4dannjjm 577 31 ) ) -RRB- cord-023095-4dannjjm 577 32 . . . cord-023095-4dannjjm 578 1 Significantly significantly RB cord-023095-4dannjjm 578 2 higher high JJR cord-023095-4dannjjm 578 3 5HT 5ht NN cord-023095-4dannjjm 578 4 concentrations concentration NNS cord-023095-4dannjjm 578 5 were be VBD cord-023095-4dannjjm 578 6 observed observe VBN cord-023095-4dannjjm 578 7 in in IN cord-023095-4dannjjm 578 8 dogs dog NNS cord-023095-4dannjjm 578 9 with with IN cord-023095-4dannjjm 578 10 moderate moderate JJ cord-023095-4dannjjm 578 11 ( ( -LRB- cord-023095-4dannjjm 578 12 P p NN cord-023095-4dannjjm 578 13 o o NN cord-023095-4dannjjm 578 14 .05 .05 NFP cord-023095-4dannjjm 578 15 ) ) -RRB- cord-023095-4dannjjm 578 16 and and CC cord-023095-4dannjjm 578 17 severe severe JJ cord-023095-4dannjjm 578 18 ( ( -LRB- cord-023095-4dannjjm 578 19 P p NN cord-023095-4dannjjm 578 20 o o NN cord-023095-4dannjjm 578 21 .05 .05 NFP cord-023095-4dannjjm 578 22 ) ) -RRB- cord-023095-4dannjjm 578 23 DMVD DMVD NNS cord-023095-4dannjjm 578 24 , , , cord-023095-4dannjjm 578 25 compared compare VBN cord-023095-4dannjjm 578 26 with with IN cord-023095-4dannjjm 578 27 concentration concentration NN cord-023095-4dannjjm 578 28 in in IN cord-023095-4dannjjm 578 29 control control NN cord-023095-4dannjjm 578 30 group group NN cord-023095-4dannjjm 578 31 . . . cord-023095-4dannjjm 579 1 Additionally additionally RB cord-023095-4dannjjm 579 2 , , , cord-023095-4dannjjm 579 3 5HT 5ht NN cord-023095-4dannjjm 579 4 concentration concentration NN cord-023095-4dannjjm 579 5 in in IN cord-023095-4dannjjm 579 6 dogs dog NNS cord-023095-4dannjjm 579 7 with with IN cord-023095-4dannjjm 579 8 moderate moderate JJ cord-023095-4dannjjm 579 9 DMVD DMVD NNS cord-023095-4dannjjm 579 10 were be VBD cord-023095-4dannjjm 579 11 significantly significantly RB cord-023095-4dannjjm 579 12 higher high JJR cord-023095-4dannjjm 580 1 ( ( -LRB- cord-023095-4dannjjm 580 2 P p NN cord-023095-4dannjjm 580 3 o o NN cord-023095-4dannjjm 580 4 .05 .05 NFP cord-023095-4dannjjm 580 5 ) ) -RRB- cord-023095-4dannjjm 580 6 than than IN cord-023095-4dannjjm 580 7 concentration concentration NN cord-023095-4dannjjm 580 8 in in IN cord-023095-4dannjjm 580 9 dogs dog NNS cord-023095-4dannjjm 580 10 with with IN cord-023095-4dannjjm 580 11 mild mild JJ cord-023095-4dannjjm 580 12 DMVD DMVD NNS cord-023095-4dannjjm 580 13 . . . cord-023095-4dannjjm 581 1 Also also RB cord-023095-4dannjjm 581 2 , , , cord-023095-4dannjjm 581 3 dogs dog NNS cord-023095-4dannjjm 581 4 with with IN cord-023095-4dannjjm 581 5 severe severe JJ cord-023095-4dannjjm 581 6 DMVD DMVD NNS cord-023095-4dannjjm 581 7 had have VBD cord-023095-4dannjjm 581 8 significantly significantly RB cord-023095-4dannjjm 581 9 higher high JJR cord-023095-4dannjjm 581 10 5HT 5ht NN cord-023095-4dannjjm 581 11 concentration concentration NN cord-023095-4dannjjm 581 12 than than IN cord-023095-4dannjjm 581 13 dogs dog NNS cord-023095-4dannjjm 581 14 with with IN cord-023095-4dannjjm 581 15 mild mild JJ cord-023095-4dannjjm 581 16 ( ( -LRB- cord-023095-4dannjjm 581 17 P p NN cord-023095-4dannjjm 581 18 o o NN cord-023095-4dannjjm 581 19 .05 .05 NFP cord-023095-4dannjjm 581 20 ) ) -RRB- cord-023095-4dannjjm 581 21 and and CC cord-023095-4dannjjm 581 22 moderate moderate JJ cord-023095-4dannjjm 581 23 ( ( -LRB- cord-023095-4dannjjm 581 24 P p NN cord-023095-4dannjjm 581 25 o o NN cord-023095-4dannjjm 581 26 .05 .05 NFP cord-023095-4dannjjm 581 27 ) ) -RRB- cord-023095-4dannjjm 581 28 DMVD DMVD NNS cord-023095-4dannjjm 581 29 . . . cord-023095-4dannjjm 582 1 There there EX cord-023095-4dannjjm 582 2 was be VBD cord-023095-4dannjjm 582 3 no no DT cord-023095-4dannjjm 582 4 significant significant JJ cord-023095-4dannjjm 582 5 association association NN cord-023095-4dannjjm 582 6 of of IN cord-023095-4dannjjm 582 7 age age NN cord-023095-4dannjjm 582 8 , , , cord-023095-4dannjjm 582 9 platelet platelet NN cord-023095-4dannjjm 582 10 , , , cord-023095-4dannjjm 582 11 and and CC cord-023095-4dannjjm 582 12 LVIDd LVIDd NNP cord-023095-4dannjjm 582 13 , , , cord-023095-4dannjjm 582 14 on on IN cord-023095-4dannjjm 582 15 serum serum NN cord-023095-4dannjjm 582 16 5HT 5ht NN cord-023095-4dannjjm 582 17 concentration concentration NN cord-023095-4dannjjm 582 18 , , , cord-023095-4dannjjm 582 19 however however RB cord-023095-4dannjjm 582 20 , , , cord-023095-4dannjjm 582 21 weak weak JJ cord-023095-4dannjjm 582 22 correlation correlation NN cord-023095-4dannjjm 582 23 between between IN cord-023095-4dannjjm 582 24 serum serum NN cord-023095-4dannjjm 582 25 5HT 5ht NN cord-023095-4dannjjm 582 26 increased increase VBD cord-023095-4dannjjm 582 27 significantly significantly RB cord-023095-4dannjjm 582 28 and and CC cord-023095-4dannjjm 582 29 LA LA NNP cord-023095-4dannjjm 582 30 : : : cord-023095-4dannjjm 583 1 Ao Ao NNP cord-023095-4dannjjm 583 2 ratio ratio NN cord-023095-4dannjjm 583 3 ( ( -LRB- cord-023095-4dannjjm 583 4 R r NN cord-023095-4dannjjm 583 5 2 2 CD cord-023095-4dannjjm 583 6 5 5 CD cord-023095-4dannjjm 583 7 .211 .211 CD cord-023095-4dannjjm 583 8 , , , cord-023095-4dannjjm 584 1 P p NN cord-023095-4dannjjm 584 2 o o NN cord-023095-4dannjjm 584 3 .05 .05 NFP cord-023095-4dannjjm 584 4 ) ) -RRB- cord-023095-4dannjjm 584 5 was be VBD cord-023095-4dannjjm 584 6 observed observe VBN cord-023095-4dannjjm 584 7 . . . cord-023095-4dannjjm 585 1 The the DT cord-023095-4dannjjm 585 2 results result NNS cord-023095-4dannjjm 585 3 of of IN cord-023095-4dannjjm 585 4 this this DT cord-023095-4dannjjm 585 5 study study NN cord-023095-4dannjjm 585 6 indicate indicate VBP cord-023095-4dannjjm 585 7 that that IN cord-023095-4dannjjm 585 8 serum serum NN cord-023095-4dannjjm 585 9 5HT 5ht NN cord-023095-4dannjjm 585 10 concentrations concentration NNS cord-023095-4dannjjm 585 11 were be VBD cord-023095-4dannjjm 585 12 higher high JJR cord-023095-4dannjjm 585 13 with with IN cord-023095-4dannjjm 585 14 increasing increase VBG cord-023095-4dannjjm 585 15 severity severity NN cord-023095-4dannjjm 585 16 of of IN cord-023095-4dannjjm 585 17 spontaneous spontaneous JJ cord-023095-4dannjjm 585 18 DMVD DMVD NNS cord-023095-4dannjjm 585 19 , , , cord-023095-4dannjjm 585 20 which which WDT cord-023095-4dannjjm 585 21 may may MD cord-023095-4dannjjm 585 22 be be VB cord-023095-4dannjjm 585 23 the the DT cord-023095-4dannjjm 585 24 potential potential JJ cord-023095-4dannjjm 585 25 cause cause NN cord-023095-4dannjjm 585 26 to to TO cord-023095-4dannjjm 585 27 advance advance VB cord-023095-4dannjjm 585 28 the the DT cord-023095-4dannjjm 585 29 progression progression NN cord-023095-4dannjjm 585 30 of of IN cord-023095-4dannjjm 585 31 DMVD DMVD NNP cord-023095-4dannjjm 585 32 . . . cord-023095-4dannjjm 586 1 Further further JJ cord-023095-4dannjjm 586 2 studies study NNS cord-023095-4dannjjm 586 3 should should MD cord-023095-4dannjjm 586 4 be be VB cord-023095-4dannjjm 586 5 performed perform VBN cord-023095-4dannjjm 586 6 to to TO cord-023095-4dannjjm 586 7 reveal reveal VB cord-023095-4dannjjm 586 8 the the DT cord-023095-4dannjjm 586 9 role role NN cord-023095-4dannjjm 586 10 of of IN cord-023095-4dannjjm 586 11 5HT 5ht NN cord-023095-4dannjjm 586 12 in in IN cord-023095-4dannjjm 586 13 inducing induce VBG cord-023095-4dannjjm 586 14 and and CC cord-023095-4dannjjm 586 15 accelerating accelerate VBG cord-023095-4dannjjm 586 16 spontaneous spontaneous JJ cord-023095-4dannjjm 586 17 DMVD DMVD NNS cord-023095-4dannjjm 586 18 and and CC cord-023095-4dannjjm 586 19 to to TO cord-023095-4dannjjm 586 20 investigate investigate VB cord-023095-4dannjjm 586 21 if if IN cord-023095-4dannjjm 586 22 lowering lower VBG cord-023095-4dannjjm 586 23 serum serum NN cord-023095-4dannjjm 586 24 5HT 5ht NN cord-023095-4dannjjm 586 25 concentration concentration NN cord-023095-4dannjjm 586 26 could could MD cord-023095-4dannjjm 586 27 alter alter VB cord-023095-4dannjjm 586 28 the the DT cord-023095-4dannjjm 586 29 progression progression NN cord-023095-4dannjjm 586 30 of of IN cord-023095-4dannjjm 586 31 DMVD DMVD NNS cord-023095-4dannjjm 586 32 . . . cord-023095-4dannjjm 587 1 The the DT cord-023095-4dannjjm 587 2 objective objective NN cord-023095-4dannjjm 587 3 of of IN cord-023095-4dannjjm 587 4 this this DT cord-023095-4dannjjm 587 5 prospective prospective JJ cord-023095-4dannjjm 587 6 study study NN cord-023095-4dannjjm 587 7 was be VBD cord-023095-4dannjjm 587 8 to to TO cord-023095-4dannjjm 587 9 evaluate evaluate VB cord-023095-4dannjjm 587 10 the the DT cord-023095-4dannjjm 587 11 utility utility NN cord-023095-4dannjjm 587 12 of of IN cord-023095-4dannjjm 587 13 cardiac cardiac NN cord-023095-4dannjjm 587 14 troponin troponin NN cord-023095-4dannjjm 587 15 I -PRON- PRP cord-023095-4dannjjm 587 16 ( ( -LRB- cord-023095-4dannjjm 587 17 cTnI cTnI NNP cord-023095-4dannjjm 587 18 ) ) -RRB- cord-023095-4dannjjm 587 19 in in IN cord-023095-4dannjjm 587 20 differentiating differentiate VBG cord-023095-4dannjjm 587 21 between between IN cord-023095-4dannjjm 587 22 underlying underlying JJ cord-023095-4dannjjm 587 23 etiologies etiology NNS cord-023095-4dannjjm 587 24 of of IN cord-023095-4dannjjm 587 25 pericardial pericardial JJ cord-023095-4dannjjm 587 26 effusion effusion NN cord-023095-4dannjjm 587 27 in in IN cord-023095-4dannjjm 587 28 the the DT cord-023095-4dannjjm 587 29 canine canine JJ cord-023095-4dannjjm 587 30 patient patient NN cord-023095-4dannjjm 587 31 . . . cord-023095-4dannjjm 588 1 Patients patient NNS cord-023095-4dannjjm 588 2 were be VBD cord-023095-4dannjjm 588 3 prospectively prospectively RB cord-023095-4dannjjm 588 4 recruited recruit VBN cord-023095-4dannjjm 588 5 at at IN cord-023095-4dannjjm 588 6 time time NN cord-023095-4dannjjm 588 7 of of IN cord-023095-4dannjjm 588 8 diagnosis diagnosis NN cord-023095-4dannjjm 588 9 of of IN cord-023095-4dannjjm 588 10 novel novel JJ cord-023095-4dannjjm 588 11 pericardial pericardial JJ cord-023095-4dannjjm 588 12 effusion effusion NN cord-023095-4dannjjm 588 13 . . . cord-023095-4dannjjm 589 1 Serum serum NN cord-023095-4dannjjm 589 2 samples sample NNS cord-023095-4dannjjm 589 3 were be VBD cord-023095-4dannjjm 589 4 collected collect VBN cord-023095-4dannjjm 589 5 prior prior RB cord-023095-4dannjjm 589 6 to to IN cord-023095-4dannjjm 589 7 pericardiocentesis pericardiocentesis NN cord-023095-4dannjjm 589 8 . . . cord-023095-4dannjjm 590 1 Patients patient NNS cord-023095-4dannjjm 590 2 were be VBD cord-023095-4dannjjm 590 3 evaluated evaluate VBN cord-023095-4dannjjm 590 4 by by IN cord-023095-4dannjjm 590 5 echocardiography echocardiography NN cord-023095-4dannjjm 590 6 and and CC cord-023095-4dannjjm 590 7 classified classify VBN cord-023095-4dannjjm 590 8 with with IN cord-023095-4dannjjm 590 9 the the DT cord-023095-4dannjjm 590 10 diagnosis diagnosis NN cord-023095-4dannjjm 590 11 of of IN cord-023095-4dannjjm 590 12 hemangiosarcoma hemangiosarcoma NN cord-023095-4dannjjm 590 13 ( ( -LRB- cord-023095-4dannjjm 590 14 HSA HSA NNP cord-023095-4dannjjm 590 15 ) ) -RRB- cord-023095-4dannjjm 590 16 , , , cord-023095-4dannjjm 590 17 heart heart NN cord-023095-4dannjjm 590 18 base base NN cord-023095-4dannjjm 590 19 tumor tumor NN cord-023095-4dannjjm 590 20 ( ( -LRB- cord-023095-4dannjjm 590 21 HBT HBT NNP cord-023095-4dannjjm 590 22 ) ) -RRB- cord-023095-4dannjjm 590 23 , , , cord-023095-4dannjjm 590 24 or or CC cord-023095-4dannjjm 590 25 unknown unknown JJ cord-023095-4dannjjm 590 26 etiology etiology NN cord-023095-4dannjjm 590 27 at at IN cord-023095-4dannjjm 590 28 the the DT cord-023095-4dannjjm 590 29 initial initial JJ cord-023095-4dannjjm 590 30 evaluation evaluation NN cord-023095-4dannjjm 590 31 based base VBN cord-023095-4dannjjm 590 32 on on IN cord-023095-4dannjjm 590 33 established establish VBN cord-023095-4dannjjm 590 34 characteristic characteristic JJ cord-023095-4dannjjm 590 35 echocardiographic echocardiographic JJ cord-023095-4dannjjm 590 36 findings finding NNS cord-023095-4dannjjm 590 37 . . . cord-023095-4dannjjm 591 1 Idiopathic idiopathic JJ cord-023095-4dannjjm 591 2 pericardial pericardial JJ cord-023095-4dannjjm 591 3 effusion effusion NN cord-023095-4dannjjm 591 4 ( ( -LRB- cord-023095-4dannjjm 591 5 IPE IPE NNP cord-023095-4dannjjm 591 6 ) ) -RRB- cord-023095-4dannjjm 591 7 was be VBD cord-023095-4dannjjm 591 8 defined define VBN cord-023095-4dannjjm 591 9 by by IN cord-023095-4dannjjm 591 10 histopathology histopathology NN cord-023095-4dannjjm 591 11 , , , cord-023095-4dannjjm 591 12 echonegative echonegative NNP cord-023095-4dannjjm 591 13 for for IN cord-023095-4dannjjm 591 14 a a DT cord-023095-4dannjjm 591 15 mass mass JJ cord-023095-4dannjjm 591 16 lesion lesion NN cord-023095-4dannjjm 591 17 with with IN cord-023095-4dannjjm 591 18 no no DT cord-023095-4dannjjm 591 19 recurrence recurrence NN cord-023095-4dannjjm 591 20 of of IN cord-023095-4dannjjm 591 21 pericardial pericardial JJ cord-023095-4dannjjm 591 22 effusion effusion NN cord-023095-4dannjjm 591 23 46 46 CD cord-023095-4dannjjm 591 24 months month NNS cord-023095-4dannjjm 591 25 , , , cord-023095-4dannjjm 591 26 or or CC cord-023095-4dannjjm 591 27 symptom symptom NN cord-023095-4dannjjm 591 28 free free JJ cord-023095-4dannjjm 591 29 412 412 CD cord-023095-4dannjjm 591 30 months month NNS cord-023095-4dannjjm 591 31 from from IN cord-023095-4dannjjm 591 32 time time NN cord-023095-4dannjjm 591 33 of of IN cord-023095-4dannjjm 591 34 enrollment enrollment NN cord-023095-4dannjjm 591 35 . . . cord-023095-4dannjjm 592 1 Patients patient NNS cord-023095-4dannjjm 592 2 were be VBD cord-023095-4dannjjm 592 3 excluded exclude VBN cord-023095-4dannjjm 592 4 from from IN cord-023095-4dannjjm 592 5 analysis analysis NN cord-023095-4dannjjm 592 6 if if IN cord-023095-4dannjjm 592 7 a a DT cord-023095-4dannjjm 592 8 diagnosis diagnosis NN cord-023095-4dannjjm 592 9 could could MD cord-023095-4dannjjm 592 10 not not RB cord-023095-4dannjjm 592 11 be be VB cord-023095-4dannjjm 592 12 established establish VBN cord-023095-4dannjjm 592 13 based base VBN cord-023095-4dannjjm 592 14 on on IN cord-023095-4dannjjm 592 15 above above JJ cord-023095-4dannjjm 592 16 criteria criterion NNS cord-023095-4dannjjm 592 17 or or CC cord-023095-4dannjjm 592 18 concurrent concurrent JJ cord-023095-4dannjjm 592 19 moderate moderate JJ cord-023095-4dannjjm 592 20 azotemia azotemia NN cord-023095-4dannjjm 592 21 ( ( -LRB- cord-023095-4dannjjm 592 22 Creatinine creatinine NN cord-023095-4dannjjm 592 23 43.0 43.0 CD cord-023095-4dannjjm 592 24 mg mg NNP cord-023095-4dannjjm 592 25 / / SYM cord-023095-4dannjjm 592 26 dL dL NNP cord-023095-4dannjjm 592 27 ) ) -RRB- cord-023095-4dannjjm 592 28 was be VBD cord-023095-4dannjjm 592 29 present present JJ cord-023095-4dannjjm 592 30 at at IN cord-023095-4dannjjm 592 31 time time NN cord-023095-4dannjjm 592 32 of of IN cord-023095-4dannjjm 592 33 sample sample NN cord-023095-4dannjjm 592 34 collection collection NN cord-023095-4dannjjm 592 35 . . . cord-023095-4dannjjm 593 1 Serum serum NN cord-023095-4dannjjm 593 2 samples sample NNS cord-023095-4dannjjm 593 3 were be VBD cord-023095-4dannjjm 593 4 frozen freeze VBN cord-023095-4dannjjm 593 5 and and CC cord-023095-4dannjjm 593 6 analyzed analyze VBN cord-023095-4dannjjm 593 7 in in IN cord-023095-4dannjjm 593 8 batches batch NNS cord-023095-4dannjjm 593 9 within within IN cord-023095-4dannjjm 593 10 60 60 CD cord-023095-4dannjjm 593 11 days day NNS cord-023095-4dannjjm 593 12 of of IN cord-023095-4dannjjm 593 13 collection collection NN cord-023095-4dannjjm 593 14 by by IN cord-023095-4dannjjm 593 15 a a DT cord-023095-4dannjjm 593 16 cTnI ctni JJ cord-023095-4dannjjm 593 17 assay assay NN cord-023095-4dannjjm 593 18 with with IN cord-023095-4dannjjm 593 19 a a DT cord-023095-4dannjjm 593 20 0.2ng 0.2ng CD cord-023095-4dannjjm 593 21 / / SYM cord-023095-4dannjjm 593 22 mL ml NN cord-023095-4dannjjm 593 23 lower low JJR cord-023095-4dannjjm 593 24 limit limit NN cord-023095-4dannjjm 593 25 sensitivity sensitivity NN cord-023095-4dannjjm 593 26 . . . cord-023095-4dannjjm 594 1 Sixty sixty CD cord-023095-4dannjjm 594 2 - - HYPH cord-023095-4dannjjm 594 3 three three CD cord-023095-4dannjjm 594 4 patients patient NNS cord-023095-4dannjjm 594 5 were be VBD cord-023095-4dannjjm 594 6 recruited recruit VBN cord-023095-4dannjjm 594 7 over over IN cord-023095-4dannjjm 594 8 a a DT cord-023095-4dannjjm 594 9 one one CD cord-023095-4dannjjm 594 10 year year NN cord-023095-4dannjjm 594 11 period period NN cord-023095-4dannjjm 594 12 with with IN cord-023095-4dannjjm 594 13 15 15 CD cord-023095-4dannjjm 594 14 patients patient NNS cord-023095-4dannjjm 594 15 excluded exclude VBN cord-023095-4dannjjm 594 16 due due IN cord-023095-4dannjjm 594 17 to to IN cord-023095-4dannjjm 594 18 lack lack NN cord-023095-4dannjjm 594 19 of of IN cord-023095-4dannjjm 594 20 diagnosis diagnosis NN cord-023095-4dannjjm 594 21 ( ( -LRB- cord-023095-4dannjjm 594 22 13 13 CD cord-023095-4dannjjm 594 23 ) ) -RRB- cord-023095-4dannjjm 594 24 or or CC cord-023095-4dannjjm 594 25 azotemia azotemia NNP cord-023095-4dannjjm 594 26 ( ( -LRB- cord-023095-4dannjjm 594 27 2 2 CD cord-023095-4dannjjm 594 28 ) ) -RRB- cord-023095-4dannjjm 594 29 . . . cord-023095-4dannjjm 595 1 Median median JJ cord-023095-4dannjjm 595 2 cTnI ctni JJ cord-023095-4dannjjm 595 3 levels level NNS cord-023095-4dannjjm 595 4 of of IN cord-023095-4dannjjm 595 5 dogs dog NNS cord-023095-4dannjjm 595 6 with with IN cord-023095-4dannjjm 595 7 HSA HSA NNP cord-023095-4dannjjm 595 8 ( ( -LRB- cord-023095-4dannjjm 595 9 n n NN cord-023095-4dannjjm 595 10 5 5 CD cord-023095-4dannjjm 595 11 24 24 CD cord-023095-4dannjjm 595 12 ) ) -RRB- cord-023095-4dannjjm 595 13 , , , cord-023095-4dannjjm 595 14 HBT HBT NNP cord-023095-4dannjjm 595 15 ( ( -LRB- cord-023095-4dannjjm 595 16 n n NN cord-023095-4dannjjm 595 17 5 5 CD cord-023095-4dannjjm 595 18 19 19 CD cord-023095-4dannjjm 595 19 ) ) -RRB- cord-023095-4dannjjm 595 20 , , , cord-023095-4dannjjm 595 21 and and CC cord-023095-4dannjjm 595 22 IPE IPE NNP cord-023095-4dannjjm 595 23 ( ( -LRB- cord-023095-4dannjjm 595 24 n n NN cord-023095-4dannjjm 595 25 5 5 CD cord-023095-4dannjjm 595 26 5 5 CD cord-023095-4dannjjm 595 27 ) ) -RRB- cord-023095-4dannjjm 595 28 were be VBD cord-023095-4dannjjm 595 29 14.8 14.8 CD cord-023095-4dannjjm 595 30 ng ng NN cord-023095-4dannjjm 595 31 / / SYM cord-023095-4dannjjm 595 32 dL dl NN cord-023095-4dannjjm 596 1 ( ( -LRB- cord-023095-4dannjjm 596 2 interquartile interquartile JJ cord-023095-4dannjjm 596 3 range range NN cord-023095-4dannjjm 596 4 ( ( -LRB- cord-023095-4dannjjm 596 5 IQR iqr NN cord-023095-4dannjjm 596 6 ) ) -RRB- cord-023095-4dannjjm 597 1 o o LS cord-023095-4dannjjm 597 2 0.2 0.2 CD cord-023095-4dannjjm 597 3 - - HYPH cord-023095-4dannjjm 597 4 11.3 11.3 CD cord-023095-4dannjjm 597 5 ) ) -RRB- cord-023095-4dannjjm 597 6 , , , cord-023095-4dannjjm 597 7 0.23 0.23 CD cord-023095-4dannjjm 597 8 ng ng NN cord-023095-4dannjjm 597 9 / / SYM cord-023095-4dannjjm 597 10 dL dl NN cord-023095-4dannjjm 598 1 ( ( -LRB- cord-023095-4dannjjm 598 2 IQR IQR NNP cord-023095-4dannjjm 598 3 o o NNP cord-023095-4dannjjm 598 4 0.2 0.2 CD cord-023095-4dannjjm 598 5 - - HYPH cord-023095-4dannjjm 598 6 0.29 0.29 CD cord-023095-4dannjjm 598 7 ) ) -RRB- cord-023095-4dannjjm 598 8 , , , cord-023095-4dannjjm 598 9 and and CC cord-023095-4dannjjm 598 10 o o NN cord-023095-4dannjjm 598 11 0.2 0.2 CD cord-023095-4dannjjm 598 12 ng ng NN cord-023095-4dannjjm 598 13 / / SYM cord-023095-4dannjjm 598 14 dL dl NN cord-023095-4dannjjm 599 1 ( ( -LRB- cord-023095-4dannjjm 599 2 IQR IQR NNP cord-023095-4dannjjm 599 3 o o NNP cord-023095-4dannjjm 599 4 0.2-o 0.2-o CD cord-023095-4dannjjm 599 5 0.2 0.2 CD cord-023095-4dannjjm 599 6 ) ) -RRB- cord-023095-4dannjjm 599 7 respectively respectively RB cord-023095-4dannjjm 599 8 . . . cord-023095-4dannjjm 600 1 Concentrations concentration NNS cord-023095-4dannjjm 600 2 of of IN cord-023095-4dannjjm 600 3 cTnI cTnI NNP cord-023095-4dannjjm 600 4 differed differ VBD cord-023095-4dannjjm 600 5 significantly significantly RB cord-023095-4dannjjm 600 6 between between IN cord-023095-4dannjjm 600 7 dogs dog NNS cord-023095-4dannjjm 600 8 with with IN cord-023095-4dannjjm 600 9 HSA HSA NNP cord-023095-4dannjjm 600 10 and and CC cord-023095-4dannjjm 600 11 HBT HBT NNP cord-023095-4dannjjm 600 12 ( ( -LRB- cord-023095-4dannjjm 600 13 p p NN cord-023095-4dannjjm 600 14 5 5 CD cord-023095-4dannjjm 600 15 0.001 0.001 CD cord-023095-4dannjjm 600 16 ) ) -RRB- cord-023095-4dannjjm 600 17 and and CC cord-023095-4dannjjm 600 18 IPE IPE NNP cord-023095-4dannjjm 600 19 ( ( -LRB- cord-023095-4dannjjm 600 20 p p NN cord-023095-4dannjjm 600 21 5 5 CD cord-023095-4dannjjm 600 22 0.0029 0.0029 CD cord-023095-4dannjjm 600 23 ) ) -RRB- cord-023095-4dannjjm 600 24 . . . cord-023095-4dannjjm 601 1 There there EX cord-023095-4dannjjm 601 2 was be VBD cord-023095-4dannjjm 601 3 no no DT cord-023095-4dannjjm 601 4 difference difference NN cord-023095-4dannjjm 601 5 between between IN cord-023095-4dannjjm 601 6 cTnI cTnI NNP cord-023095-4dannjjm 601 7 concentrations concentration NNS cord-023095-4dannjjm 601 8 between between IN cord-023095-4dannjjm 601 9 HBT HBT NNP cord-023095-4dannjjm 601 10 and and CC cord-023095-4dannjjm 601 11 IPE IPE NNP cord-023095-4dannjjm 601 12 dogs dog NNS cord-023095-4dannjjm 601 13 ( ( -LRB- cord-023095-4dannjjm 601 14 p p NN cord-023095-4dannjjm 601 15 5 5 CD cord-023095-4dannjjm 601 16 0.911 0.911 CD cord-023095-4dannjjm 601 17 ) ) -RRB- cord-023095-4dannjjm 601 18 . . . cord-023095-4dannjjm 602 1 Receiver receiver NN cord-023095-4dannjjm 602 2 operating operating NN cord-023095-4dannjjm 602 3 curve curve NN cord-023095-4dannjjm 602 4 analysis analysis NN cord-023095-4dannjjm 602 5 to to TO cord-023095-4dannjjm 602 6 determine determine VB cord-023095-4dannjjm 602 7 the the DT cord-023095-4dannjjm 602 8 optimal optimal JJ cord-023095-4dannjjm 602 9 cutoff cutoff NN cord-023095-4dannjjm 602 10 for for IN cord-023095-4dannjjm 602 11 differentiation differentiation NN cord-023095-4dannjjm 602 12 of of IN cord-023095-4dannjjm 602 13 dogs dog NNS cord-023095-4dannjjm 602 14 affected affect VBN cord-023095-4dannjjm 602 15 with with IN cord-023095-4dannjjm 602 16 HSA HSA NNP cord-023095-4dannjjm 602 17 and and CC cord-023095-4dannjjm 602 18 both both DT cord-023095-4dannjjm 602 19 HBT HBT NNP cord-023095-4dannjjm 602 20 and and CC cord-023095-4dannjjm 602 21 IPE IPE NNP cord-023095-4dannjjm 602 22 revealed reveal VBD cord-023095-4dannjjm 602 23 a a DT cord-023095-4dannjjm 602 24 significant significant JJ cord-023095-4dannjjm 602 25 ( ( -LRB- cord-023095-4dannjjm 602 26 p p NN cord-023095-4dannjjm 602 27 5 5 CD cord-023095-4dannjjm 602 28 o o NN cord-023095-4dannjjm 602 29 0.001 0.001 CD cord-023095-4dannjjm 602 30 ) ) -RRB- cord-023095-4dannjjm 602 31 area area NN cord-023095-4dannjjm 602 32 under under IN cord-023095-4dannjjm 602 33 the the DT cord-023095-4dannjjm 602 34 curve curve NN cord-023095-4dannjjm 602 35 ( ( -LRB- cord-023095-4dannjjm 602 36 0.79 0.79 CD cord-023095-4dannjjm 602 37 ) ) -RRB- cord-023095-4dannjjm 602 38 . . . cord-023095-4dannjjm 603 1 A a DT cord-023095-4dannjjm 603 2 cut cut VB cord-023095-4dannjjm 603 3 - - HYPH cord-023095-4dannjjm 603 4 off off RP cord-023095-4dannjjm 603 5 point point NN cord-023095-4dannjjm 603 6 of of IN cord-023095-4dannjjm 603 7 cTnI cTnI NNP cord-023095-4dannjjm 603 8 of of IN cord-023095-4dannjjm 603 9 40.78 40.78 CD cord-023095-4dannjjm 603 10 yielded yield VBD cord-023095-4dannjjm 603 11 a a DT cord-023095-4dannjjm 603 12 sensitivity sensitivity NN cord-023095-4dannjjm 603 13 of of IN cord-023095-4dannjjm 603 14 67 67 CD cord-023095-4dannjjm 603 15 % % NN cord-023095-4dannjjm 603 16 ( ( -LRB- cord-023095-4dannjjm 603 17 95 95 CD cord-023095-4dannjjm 603 18 % % NN cord-023095-4dannjjm 603 19 CI CI NNP cord-023095-4dannjjm 603 20 , , , cord-023095-4dannjjm 603 21 45 45 CD cord-023095-4dannjjm 603 22 - - SYM cord-023095-4dannjjm 603 23 84 84 CD cord-023095-4dannjjm 603 24 % % NN cord-023095-4dannjjm 603 25 ) ) -RRB- cord-023095-4dannjjm 603 26 and and CC cord-023095-4dannjjm 603 27 specificity specificity NN cord-023095-4dannjjm 603 28 of of IN cord-023095-4dannjjm 603 29 95 95 CD cord-023095-4dannjjm 603 30 % % NN cord-023095-4dannjjm 603 31 ( ( -LRB- cord-023095-4dannjjm 603 32 95 95 CD cord-023095-4dannjjm 603 33 % % NN cord-023095-4dannjjm 603 34 CI CI NNP cord-023095-4dannjjm 603 35 , , , cord-023095-4dannjjm 603 36 79 79 CD cord-023095-4dannjjm 603 37 - - SYM cord-023095-4dannjjm 603 38 99 99 CD cord-023095-4dannjjm 603 39 % % NN cord-023095-4dannjjm 603 40 ) ) -RRB- cord-023095-4dannjjm 603 41 . . . cord-023095-4dannjjm 604 1 Utilizing utilize VBG cord-023095-4dannjjm 604 2 a a DT cord-023095-4dannjjm 604 3 higher high JJR cord-023095-4dannjjm 604 4 cut cut VBN cord-023095-4dannjjm 604 5 - - HYPH cord-023095-4dannjjm 604 6 off off RP cord-023095-4dannjjm 604 7 point point NN cord-023095-4dannjjm 604 8 of of IN cord-023095-4dannjjm 604 9 43.0 43.0 CD cord-023095-4dannjjm 604 10 yielded yield VBD cord-023095-4dannjjm 604 11 a a DT cord-023095-4dannjjm 604 12 lower low JJR cord-023095-4dannjjm 604 13 sensitivity sensitivity NN cord-023095-4dannjjm 604 14 of of IN cord-023095-4dannjjm 604 15 50 50 CD cord-023095-4dannjjm 604 16 % % NN cord-023095-4dannjjm 604 17 ( ( -LRB- cord-023095-4dannjjm 604 18 95 95 CD cord-023095-4dannjjm 604 19 % % NN cord-023095-4dannjjm 604 20 CI CI NNP cord-023095-4dannjjm 604 21 , , , cord-023095-4dannjjm 604 22 29 29 CD cord-023095-4dannjjm 604 23 - - SYM cord-023095-4dannjjm 604 24 71 71 CD cord-023095-4dannjjm 604 25 % % NN cord-023095-4dannjjm 604 26 ) ) -RRB- cord-023095-4dannjjm 604 27 , , , cord-023095-4dannjjm 604 28 but but CC cord-023095-4dannjjm 604 29 a a DT cord-023095-4dannjjm 604 30 higher high JJR cord-023095-4dannjjm 604 31 specificity specificity NN cord-023095-4dannjjm 604 32 of of IN cord-023095-4dannjjm 604 33 100 100 CD cord-023095-4dannjjm 604 34 % % NN cord-023095-4dannjjm 604 35 ( ( -LRB- cord-023095-4dannjjm 604 36 95 95 CD cord-023095-4dannjjm 604 37 % % NN cord-023095-4dannjjm 604 38 CI CI NNP cord-023095-4dannjjm 604 39 , , , cord-023095-4dannjjm 604 40 86 86 CD cord-023095-4dannjjm 604 41 - - SYM cord-023095-4dannjjm 604 42 100 100 CD cord-023095-4dannjjm 604 43 % % NN cord-023095-4dannjjm 604 44 ) ) -RRB- cord-023095-4dannjjm 604 45 which which WDT cord-023095-4dannjjm 604 46 may may MD cord-023095-4dannjjm 604 47 have have VB cord-023095-4dannjjm 604 48 more more RBR cord-023095-4dannjjm 604 49 clinical clinical JJ cord-023095-4dannjjm 604 50 utility utility NN cord-023095-4dannjjm 604 51 given give VBN cord-023095-4dannjjm 604 52 the the DT cord-023095-4dannjjm 604 53 disparity disparity NN cord-023095-4dannjjm 604 54 in in IN cord-023095-4dannjjm 604 55 prognoses prognosis NNS cord-023095-4dannjjm 604 56 of of IN cord-023095-4dannjjm 604 57 the the DT cord-023095-4dannjjm 604 58 etiologies etiology NNS cord-023095-4dannjjm 604 59 compared compare VBN cord-023095-4dannjjm 604 60 . . . cord-023095-4dannjjm 605 1 In in IN cord-023095-4dannjjm 605 2 conclusion conclusion NN cord-023095-4dannjjm 605 3 , , , cord-023095-4dannjjm 605 4 this this DT cord-023095-4dannjjm 605 5 study study NN cord-023095-4dannjjm 605 6 supports support VBZ cord-023095-4dannjjm 605 7 the the DT cord-023095-4dannjjm 605 8 diagnostic diagnostic JJ cord-023095-4dannjjm 605 9 utility utility NN cord-023095-4dannjjm 605 10 of of IN cord-023095-4dannjjm 605 11 cTnI cTnI NNP cord-023095-4dannjjm 605 12 concentrations concentration NNS cord-023095-4dannjjm 605 13 to to TO cord-023095-4dannjjm 605 14 delineate delineate VB cord-023095-4dannjjm 605 15 between between IN cord-023095-4dannjjm 605 16 patients patient NNS cord-023095-4dannjjm 605 17 with with IN cord-023095-4dannjjm 605 18 HSA HSA NNP cord-023095-4dannjjm 605 19 and and CC cord-023095-4dannjjm 605 20 other other JJ cord-023095-4dannjjm 605 21 etiologies etiology NNS cord-023095-4dannjjm 605 22 of of IN cord-023095-4dannjjm 605 23 pericardial pericardial JJ cord-023095-4dannjjm 605 24 effusion effusion NN cord-023095-4dannjjm 605 25 , , , cord-023095-4dannjjm 605 26 but but CC cord-023095-4dannjjm 605 27 does do VBZ cord-023095-4dannjjm 605 28 not not RB cord-023095-4dannjjm 605 29 reliably reliably RB cord-023095-4dannjjm 605 30 differentiate differentiate VB cord-023095-4dannjjm 605 31 between between IN cord-023095-4dannjjm 605 32 dogs dog NNS cord-023095-4dannjjm 605 33 with with IN cord-023095-4dannjjm 605 34 IPE IPE NNP cord-023095-4dannjjm 605 35 and and CC cord-023095-4dannjjm 605 36 other other JJ cord-023095-4dannjjm 605 37 neoplastic neoplastic JJ cord-023095-4dannjjm 605 38 etiologies etiology NNS cord-023095-4dannjjm 605 39 . . . cord-023095-4dannjjm 606 1 The the DT cord-023095-4dannjjm 606 2 pathogenesis pathogenesis NN cord-023095-4dannjjm 606 3 of of IN cord-023095-4dannjjm 606 4 degenerative degenerative JJ cord-023095-4dannjjm 606 5 mitral mitral JJ cord-023095-4dannjjm 606 6 valve valve NN cord-023095-4dannjjm 606 7 disease disease NN cord-023095-4dannjjm 606 8 ( ( -LRB- cord-023095-4dannjjm 606 9 DMVD DMVD NNP cord-023095-4dannjjm 606 10 ) ) -RRB- cord-023095-4dannjjm 606 11 in in IN cord-023095-4dannjjm 606 12 dogs dog NNS cord-023095-4dannjjm 606 13 remains remain VBZ cord-023095-4dannjjm 606 14 to to TO cord-023095-4dannjjm 606 15 be be VB cord-023095-4dannjjm 606 16 fully fully RB cord-023095-4dannjjm 606 17 elucidated elucidate VBN cord-023095-4dannjjm 606 18 . . . cord-023095-4dannjjm 607 1 The the DT cord-023095-4dannjjm 607 2 high high JJ cord-023095-4dannjjm 607 3 sheer sheer JJ cord-023095-4dannjjm 607 4 stress stress NN cord-023095-4dannjjm 607 5 caused cause VBN cord-023095-4dannjjm 607 6 by by IN cord-023095-4dannjjm 607 7 mitral mitral JJ cord-023095-4dannjjm 607 8 regurgitation regurgitation NN cord-023095-4dannjjm 607 9 damages damage VBZ cord-023095-4dannjjm 607 10 the the DT cord-023095-4dannjjm 607 11 endothelial endothelial JJ cord-023095-4dannjjm 607 12 surface surface NN cord-023095-4dannjjm 607 13 of of IN cord-023095-4dannjjm 607 14 the the DT cord-023095-4dannjjm 607 15 valve valve NN cord-023095-4dannjjm 607 16 , , , cord-023095-4dannjjm 607 17 and and CC cord-023095-4dannjjm 607 18 a a DT cord-023095-4dannjjm 607 19 previous previous JJ cord-023095-4dannjjm 607 20 study study NN cord-023095-4dannjjm 607 21 demonstrated demonstrate VBD cord-023095-4dannjjm 607 22 increased increased JJ cord-023095-4dannjjm 607 23 transcription transcription NN cord-023095-4dannjjm 607 24 of of IN cord-023095-4dannjjm 607 25 intercellular intercellular JJ cord-023095-4dannjjm 607 26 adhesion adhesion NN cord-023095-4dannjjm 607 27 molecule-1 molecule-1 NN cord-023095-4dannjjm 607 28 ( ( -LRB- cord-023095-4dannjjm 607 29 ICAM-1 ICAM-1 NNP cord-023095-4dannjjm 607 30 ) ) -RRB- cord-023095-4dannjjm 607 31 and and CC cord-023095-4dannjjm 607 32 E E NNS cord-023095-4dannjjm 607 33 - - NN cord-023095-4dannjjm 607 34 selectin selectin NNS cord-023095-4dannjjm 607 35 in in IN cord-023095-4dannjjm 607 36 affected affect VBN cord-023095-4dannjjm 607 37 mitral mitral JJ cord-023095-4dannjjm 607 38 leaflet leaflet NN cord-023095-4dannjjm 607 39 tissue tissue NN cord-023095-4dannjjm 607 40 . . . cord-023095-4dannjjm 608 1 We -PRON- PRP cord-023095-4dannjjm 608 2 hypothesized hypothesize VBD cord-023095-4dannjjm 608 3 that that IN cord-023095-4dannjjm 608 4 this this DT cord-023095-4dannjjm 608 5 may may MD cord-023095-4dannjjm 608 6 be be VB cord-023095-4dannjjm 608 7 responsible responsible JJ cord-023095-4dannjjm 608 8 for for IN cord-023095-4dannjjm 608 9 platelet platelet NN cord-023095-4dannjjm 608 10 recruitment recruitment NN cord-023095-4dannjjm 608 11 and and CC cord-023095-4dannjjm 608 12 adhesion adhesion NN cord-023095-4dannjjm 608 13 , , , cord-023095-4dannjjm 608 14 and and CC cord-023095-4dannjjm 608 15 initiation initiation NN cord-023095-4dannjjm 608 16 of of IN cord-023095-4dannjjm 608 17 a a DT cord-023095-4dannjjm 608 18 proliferative proliferative JJ cord-023095-4dannjjm 608 19 cascade cascade NN cord-023095-4dannjjm 608 20 , , , cord-023095-4dannjjm 608 21 resulting result VBG cord-023095-4dannjjm 608 22 in in IN cord-023095-4dannjjm 608 23 further further JJ cord-023095-4dannjjm 608 24 myxomatous myxomatous JJ cord-023095-4dannjjm 608 25 changes change NNS cord-023095-4dannjjm 608 26 . . . cord-023095-4dannjjm 609 1 The the DT cord-023095-4dannjjm 609 2 goal goal NN cord-023095-4dannjjm 609 3 of of IN cord-023095-4dannjjm 609 4 this this DT cord-023095-4dannjjm 609 5 study study NN cord-023095-4dannjjm 609 6 was be VBD cord-023095-4dannjjm 609 7 to to TO cord-023095-4dannjjm 609 8 compare compare VB cord-023095-4dannjjm 609 9 plasma plasma NN cord-023095-4dannjjm 609 10 levels level NNS cord-023095-4dannjjm 609 11 of of IN cord-023095-4dannjjm 609 12 ICAM-1 icam-1 NN cord-023095-4dannjjm 609 13 and and CC cord-023095-4dannjjm 609 14 E E NNS cord-023095-4dannjjm 609 15 - - NN cord-023095-4dannjjm 609 16 selectin selectin JJ cord-023095-4dannjjm 609 17 in in IN cord-023095-4dannjjm 609 18 healthy healthy JJ cord-023095-4dannjjm 609 19 dogs dog NNS cord-023095-4dannjjm 609 20 and and CC cord-023095-4dannjjm 609 21 those those DT cord-023095-4dannjjm 609 22 with with IN cord-023095-4dannjjm 609 23 DMVD DMVD NNS cord-023095-4dannjjm 609 24 . . . cord-023095-4dannjjm 610 1 The the DT cord-023095-4dannjjm 610 2 study study NN cord-023095-4dannjjm 610 3 population population NN cord-023095-4dannjjm 610 4 included include VBD cord-023095-4dannjjm 610 5 dogs dog NNS cord-023095-4dannjjm 610 6 with with IN cord-023095-4dannjjm 610 7 echocardiographic echocardiographic JJ cord-023095-4dannjjm 610 8 evidence evidence NN cord-023095-4dannjjm 610 9 of of IN cord-023095-4dannjjm 610 10 DMVD DMVD NNP cord-023095-4dannjjm 610 11 and and CC cord-023095-4dannjjm 610 12 healthy healthy JJ cord-023095-4dannjjm 610 13 control control NN cord-023095-4dannjjm 610 14 dogs dog NNS cord-023095-4dannjjm 610 15 41 41 CD cord-023095-4dannjjm 610 16 year year NN cord-023095-4dannjjm 610 17 old old JJ cord-023095-4dannjjm 610 18 with with IN cord-023095-4dannjjm 610 19 no no DT cord-023095-4dannjjm 610 20 heart heart NN cord-023095-4dannjjm 610 21 murmur murmur NN cord-023095-4dannjjm 610 22 or or CC cord-023095-4dannjjm 610 23 known know VBN cord-023095-4dannjjm 610 24 systemic systemic JJ cord-023095-4dannjjm 610 25 diseases disease NNS cord-023095-4dannjjm 610 26 . . . cord-023095-4dannjjm 611 1 DMVD DMVD NNP cord-023095-4dannjjm 611 2 dogs dog NNS cord-023095-4dannjjm 611 3 underwent undergo VBD cord-023095-4dannjjm 611 4 2D 2d JJ cord-023095-4dannjjm 611 5 / / SYM cord-023095-4dannjjm 611 6 color color NN cord-023095-4dannjjm 611 7 - - HYPH cord-023095-4dannjjm 611 8 flow flow NN cord-023095-4dannjjm 611 9 Doppler Doppler NNP cord-023095-4dannjjm 611 10 echocardiographic echocardiographic JJ cord-023095-4dannjjm 611 11 exam exam NN cord-023095-4dannjjm 611 12 . . . cord-023095-4dannjjm 612 1 Blood blood NN cord-023095-4dannjjm 612 2 samples sample NNS cord-023095-4dannjjm 612 3 were be VBD cord-023095-4dannjjm 612 4 obtained obtain VBN cord-023095-4dannjjm 612 5 for for IN cord-023095-4dannjjm 612 6 plasma plasma NN cord-023095-4dannjjm 612 7 ICAM-1 icam-1 NN cord-023095-4dannjjm 612 8 and and CC cord-023095-4dannjjm 612 9 E e NN cord-023095-4dannjjm 612 10 - - NN cord-023095-4dannjjm 612 11 selectin selectin JJ cord-023095-4dannjjm 612 12 analysis analysis NN cord-023095-4dannjjm 612 13 using use VBG cord-023095-4dannjjm 612 14 commercially commercially RB cord-023095-4dannjjm 612 15 available available JJ cord-023095-4dannjjm 612 16 ELISA ELISA NNP cord-023095-4dannjjm 612 17 kits kit NNS cord-023095-4dannjjm 612 18 . . . cord-023095-4dannjjm 613 1 The the DT cord-023095-4dannjjm 613 2 study study NN cord-023095-4dannjjm 613 3 included include VBD cord-023095-4dannjjm 613 4 34 34 CD cord-023095-4dannjjm 613 5 dogs dog NNS cord-023095-4dannjjm 613 6 , , , cord-023095-4dannjjm 613 7 of of IN cord-023095-4dannjjm 613 8 which which WDT cord-023095-4dannjjm 613 9 20 20 CD cord-023095-4dannjjm 613 10 had have VBD cord-023095-4dannjjm 613 11 DMVD DMVD NNS cord-023095-4dannjjm 613 12 and and CC cord-023095-4dannjjm 613 13 14 14 CD cord-023095-4dannjjm 613 14 were be VBD cord-023095-4dannjjm 613 15 normal normal JJ cord-023095-4dannjjm 613 16 . . . cord-023095-4dannjjm 614 1 The the DT cord-023095-4dannjjm 614 2 DMVD DMVD NNP cord-023095-4dannjjm 614 3 group group NN cord-023095-4dannjjm 614 4 had have VBD cord-023095-4dannjjm 614 5 a a DT cord-023095-4dannjjm 614 6 median median JJ cord-023095-4dannjjm 614 7 age age NN cord-023095-4dannjjm 614 8 of of IN cord-023095-4dannjjm 614 9 9.5yrs 9.5yrs CD cord-023095-4dannjjm 614 10 ) ) -RRB- cord-023095-4dannjjm 614 11 and and CC cord-023095-4dannjjm 614 12 included include VBD cord-023095-4dannjjm 614 13 6 6 CD cord-023095-4dannjjm 614 14 females female NNS cord-023095-4dannjjm 614 15 and and CC cord-023095-4dannjjm 614 16 14 14 CD cord-023095-4dannjjm 614 17 males male NNS cord-023095-4dannjjm 614 18 . . . cord-023095-4dannjjm 615 1 Two two CD cord-023095-4dannjjm 615 2 ( ( -LRB- cord-023095-4dannjjm 615 3 10 10 CD cord-023095-4dannjjm 615 4 % % NN cord-023095-4dannjjm 615 5 ) ) -RRB- cord-023095-4dannjjm 615 6 , , , cord-023095-4dannjjm 615 7 13 13 CD cord-023095-4dannjjm 615 8 ( ( -LRB- cord-023095-4dannjjm 615 9 65 65 CD cord-023095-4dannjjm 615 10 % % NN cord-023095-4dannjjm 615 11 ) ) -RRB- cord-023095-4dannjjm 615 12 , , , cord-023095-4dannjjm 615 13 2 2 CD cord-023095-4dannjjm 615 14 ( ( -LRB- cord-023095-4dannjjm 615 15 10 10 CD cord-023095-4dannjjm 615 16 % % NN cord-023095-4dannjjm 615 17 ) ) -RRB- cord-023095-4dannjjm 615 18 and and CC cord-023095-4dannjjm 615 19 3 3 CD cord-023095-4dannjjm 615 20 ( ( -LRB- cord-023095-4dannjjm 615 21 15 15 CD cord-023095-4dannjjm 615 22 % % NN cord-023095-4dannjjm 615 23 ) ) -RRB- cord-023095-4dannjjm 615 24 dogs dog NNS cord-023095-4dannjjm 615 25 were be VBD cord-023095-4dannjjm 615 26 classified classify VBN cord-023095-4dannjjm 615 27 as as IN cord-023095-4dannjjm 615 28 ISACHC ISACHC NNP cord-023095-4dannjjm 615 29 1a 1a NN cord-023095-4dannjjm 615 30 , , , cord-023095-4dannjjm 615 31 1b 1b CD cord-023095-4dannjjm 615 32 , , , cord-023095-4dannjjm 615 33 2 2 CD cord-023095-4dannjjm 615 34 and and CC cord-023095-4dannjjm 615 35 3a 3a NN cord-023095-4dannjjm 615 36 , , , cord-023095-4dannjjm 615 37 respectively respectively RB cord-023095-4dannjjm 615 38 . . . cord-023095-4dannjjm 616 1 Of of IN cord-023095-4dannjjm 616 2 the the DT cord-023095-4dannjjm 616 3 control control NN cord-023095-4dannjjm 616 4 dogs dog NNS cord-023095-4dannjjm 616 5 , , , cord-023095-4dannjjm 616 6 median median JJ cord-023095-4dannjjm 616 7 age age NN cord-023095-4dannjjm 616 8 was be VBD cord-023095-4dannjjm 616 9 4.5yrs 4.5yrs CD cord-023095-4dannjjm 616 10 [ [ -LRB- cord-023095-4dannjjm 616 11 2 2 CD cord-023095-4dannjjm 616 12 - - SYM cord-023095-4dannjjm 616 13 6.5 6.5 CD cord-023095-4dannjjm 616 14 ] ] -RRB- cord-023095-4dannjjm 616 15 , , , cord-023095-4dannjjm 616 16 with with IN cord-023095-4dannjjm 616 17 5 5 CD cord-023095-4dannjjm 616 18 females female NNS cord-023095-4dannjjm 616 19 and and CC cord-023095-4dannjjm 616 20 9 9 CD cord-023095-4dannjjm 616 21 males male NNS cord-023095-4dannjjm 616 22 . . . cord-023095-4dannjjm 617 1 There there EX cord-023095-4dannjjm 617 2 was be VBD cord-023095-4dannjjm 617 3 no no DT cord-023095-4dannjjm 617 4 statistical statistical JJ cord-023095-4dannjjm 617 5 difference difference NN cord-023095-4dannjjm 617 6 in in IN cord-023095-4dannjjm 617 7 plasma plasma NN cord-023095-4dannjjm 617 8 E e NN cord-023095-4dannjjm 617 9 - - NN cord-023095-4dannjjm 617 10 selectin selectin NNS cord-023095-4dannjjm 617 11 between between IN cord-023095-4dannjjm 617 12 control control NN cord-023095-4dannjjm 617 13 dogs dog NNS cord-023095-4dannjjm 617 14 ( ( -LRB- cord-023095-4dannjjm 617 15 median median JJ cord-023095-4dannjjm 617 16 2.71 2.71 CD cord-023095-4dannjjm 617 17 [ [ -LRB- cord-023095-4dannjjm 617 18 2.05 2.05 CD cord-023095-4dannjjm 617 19 - - SYM cord-023095-4dannjjm 617 20 7.66 7.66 CD cord-023095-4dannjjm 617 21 ] ] -RRB- cord-023095-4dannjjm 617 22 ) ) -RRB- cord-023095-4dannjjm 617 23 and and CC cord-023095-4dannjjm 617 24 those those DT cord-023095-4dannjjm 617 25 with with IN cord-023095-4dannjjm 617 26 DMVD DMVD NNS cord-023095-4dannjjm 617 27 ( ( -LRB- cord-023095-4dannjjm 617 28 2.46 2.46 CD cord-023095-4dannjjm 617 29 [ [ -LRB- cord-023095-4dannjjm 617 30 1.54 1.54 CD cord-023095-4dannjjm 617 31 - - SYM cord-023095-4dannjjm 617 32 3.55 3.55 CD cord-023095-4dannjjm 617 33 ] ] -RRB- cord-023095-4dannjjm 617 34 ) ) -RRB- cord-023095-4dannjjm 617 35 ; ; : cord-023095-4dannjjm 617 36 P p NN cord-023095-4dannjjm 617 37 5 5 CD cord-023095-4dannjjm 617 38 0.35 0.35 CD cord-023095-4dannjjm 617 39 . . . cord-023095-4dannjjm 618 1 Plasma plasma NN cord-023095-4dannjjm 618 2 ICAM-1 icam-1 NN cord-023095-4dannjjm 618 3 concentrations concentration NNS cord-023095-4dannjjm 618 4 were be VBD cord-023095-4dannjjm 618 5 higher high JJR cord-023095-4dannjjm 618 6 in in IN cord-023095-4dannjjm 618 7 DMVD DMVD NNP cord-023095-4dannjjm 618 8 dogs dog NNS cord-023095-4dannjjm 618 9 ( ( -LRB- cord-023095-4dannjjm 618 10 1.58 1.58 CD cord-023095-4dannjjm 618 11 [ [ -LRB- cord-023095-4dannjjm 618 12 1.20 1.20 CD cord-023095-4dannjjm 618 13 - - SYM cord-023095-4dannjjm 618 14 10.58 10.58 CD cord-023095-4dannjjm 618 15 ] ] -RRB- cord-023095-4dannjjm 618 16 ) ) -RRB- cord-023095-4dannjjm 618 17 than than IN cord-023095-4dannjjm 618 18 controls control NNS cord-023095-4dannjjm 618 19 ( ( -LRB- cord-023095-4dannjjm 618 20 median median NN cord-023095-4dannjjm 618 21 1.31 1.31 CD cord-023095-4dannjjm 618 22 [ [ -LRB- cord-023095-4dannjjm 618 23 1.11 1.11 CD cord-023095-4dannjjm 618 24 - - SYM cord-023095-4dannjjm 618 25 1.65 1.65 CD cord-023095-4dannjjm 618 26 ] ] -RRB- cord-023095-4dannjjm 618 27 , , , cord-023095-4dannjjm 618 28 but but CC cord-023095-4dannjjm 618 29 this this DT cord-023095-4dannjjm 618 30 difference difference NN cord-023095-4dannjjm 618 31 did do VBD cord-023095-4dannjjm 618 32 not not RB cord-023095-4dannjjm 618 33 reach reach VB cord-023095-4dannjjm 618 34 statistical statistical JJ cord-023095-4dannjjm 618 35 significance significance NN cord-023095-4dannjjm 618 36 ( ( -LRB- cord-023095-4dannjjm 618 37 P p NN cord-023095-4dannjjm 618 38 5 5 CD cord-023095-4dannjjm 618 39 0.22 0.22 CD cord-023095-4dannjjm 618 40 ) ) -RRB- cord-023095-4dannjjm 618 41 . . . cord-023095-4dannjjm 619 1 Linear linear JJ cord-023095-4dannjjm 619 2 regression regression NN cord-023095-4dannjjm 619 3 analysis analysis NN cord-023095-4dannjjm 619 4 showed show VBD cord-023095-4dannjjm 619 5 no no DT cord-023095-4dannjjm 619 6 significant significant JJ cord-023095-4dannjjm 619 7 correlation correlation NN cord-023095-4dannjjm 619 8 between between IN cord-023095-4dannjjm 619 9 ICAM-1 icam-1 NN cord-023095-4dannjjm 619 10 or or CC cord-023095-4dannjjm 619 11 E e NN cord-023095-4dannjjm 619 12 - - NN cord-023095-4dannjjm 619 13 selectin selectin JJ cord-023095-4dannjjm 619 14 and and CC cord-023095-4dannjjm 619 15 serum serum NN cord-023095-4dannjjm 619 16 serotonin serotonin NN cord-023095-4dannjjm 619 17 level level NN cord-023095-4dannjjm 619 18 , , , cord-023095-4dannjjm 619 19 NT NT NNP cord-023095-4dannjjm 619 20 - - HYPH cord-023095-4dannjjm 619 21 proBNP probnp NN cord-023095-4dannjjm 619 22 or or CC cord-023095-4dannjjm 619 23 echocardiographic echocardiographic JJ cord-023095-4dannjjm 619 24 measures measure NNS cord-023095-4dannjjm 619 25 of of IN cord-023095-4dannjjm 619 26 DMVD DMVD NNP cord-023095-4dannjjm 619 27 severity severity NN cord-023095-4dannjjm 620 1 ( ( -LRB- cord-023095-4dannjjm 620 2 LA LA NNP cord-023095-4dannjjm 620 3 : : : cord-023095-4dannjjm 621 1 Ao Ao NNP cord-023095-4dannjjm 621 2 , , , cord-023095-4dannjjm 621 3 LVIDd LVIDd NNP cord-023095-4dannjjm 621 4 : : : cord-023095-4dannjjm 622 1 Ao Ao NNP cord-023095-4dannjjm 622 2 , , , cord-023095-4dannjjm 622 3 LVIDs lvid NNS cord-023095-4dannjjm 622 4 : : : cord-023095-4dannjjm 622 5 Ao Ao NNP cord-023095-4dannjjm 622 6 ) ) -RRB- cord-023095-4dannjjm 622 7 . . . cord-023095-4dannjjm 623 1 The the DT cord-023095-4dannjjm 623 2 results result NNS cord-023095-4dannjjm 623 3 of of IN cord-023095-4dannjjm 623 4 this this DT cord-023095-4dannjjm 623 5 study study NN cord-023095-4dannjjm 623 6 demonstrate demonstrate VBP cord-023095-4dannjjm 623 7 no no DT cord-023095-4dannjjm 623 8 significant significant JJ cord-023095-4dannjjm 623 9 difference difference NN cord-023095-4dannjjm 623 10 in in IN cord-023095-4dannjjm 623 11 circulating circulate VBG cord-023095-4dannjjm 623 12 adhesion adhesion NN cord-023095-4dannjjm 623 13 molecules molecule NNS cord-023095-4dannjjm 623 14 ICAM-1 icam-1 JJ cord-023095-4dannjjm 623 15 and and CC cord-023095-4dannjjm 623 16 E E NNS cord-023095-4dannjjm 623 17 - - NN cord-023095-4dannjjm 623 18 selectin selectin NNS cord-023095-4dannjjm 623 19 in in IN cord-023095-4dannjjm 623 20 dogs dog NNS cord-023095-4dannjjm 623 21 with with IN cord-023095-4dannjjm 623 22 DMVD DMVD NNS cord-023095-4dannjjm 623 23 as as IN cord-023095-4dannjjm 623 24 compared compare VBN cord-023095-4dannjjm 623 25 with with IN cord-023095-4dannjjm 623 26 healthy healthy JJ cord-023095-4dannjjm 623 27 controls control NNS cord-023095-4dannjjm 623 28 . . . cord-023095-4dannjjm 624 1 Further further JJ cord-023095-4dannjjm 624 2 studies study NNS cord-023095-4dannjjm 624 3 investigating investigate VBG cord-023095-4dannjjm 624 4 adhesion adhesion NN cord-023095-4dannjjm 624 5 molecules molecule NNS cord-023095-4dannjjm 624 6 within within IN cord-023095-4dannjjm 624 7 the the DT cord-023095-4dannjjm 624 8 mitral mitral JJ cord-023095-4dannjjm 624 9 valve valve NN cord-023095-4dannjjm 624 10 tissue tissue NN cord-023095-4dannjjm 624 11 itself -PRON- PRP cord-023095-4dannjjm 624 12 are be VBP cord-023095-4dannjjm 624 13 likely likely RB cord-023095-4dannjjm 624 14 needed need VBN cord-023095-4dannjjm 624 15 if if IN cord-023095-4dannjjm 624 16 ICAM-1 icam-1 NN cord-023095-4dannjjm 624 17 and and CC cord-023095-4dannjjm 624 18 E E NNS cord-023095-4dannjjm 624 19 - - NN cord-023095-4dannjjm 624 20 selectin selectin NN cord-023095-4dannjjm 624 21 play play VBP cord-023095-4dannjjm 624 22 a a DT cord-023095-4dannjjm 624 23 role role NN cord-023095-4dannjjm 624 24 in in IN cord-023095-4dannjjm 624 25 the the DT cord-023095-4dannjjm 624 26 pathophysiology pathophysiology NN cord-023095-4dannjjm 624 27 of of IN cord-023095-4dannjjm 624 28 DMVD DMVD NNS cord-023095-4dannjjm 624 29 . . . cord-023095-4dannjjm 625 1 The the DT cord-023095-4dannjjm 625 2 rate rate NN cord-023095-4dannjjm 625 3 of of IN cord-023095-4dannjjm 625 4 glucose glucose NN cord-023095-4dannjjm 625 5 utilization utilization NN cord-023095-4dannjjm 625 6 in in IN cord-023095-4dannjjm 625 7 the the DT cord-023095-4dannjjm 625 8 heart heart NN cord-023095-4dannjjm 625 9 is be VBZ cord-023095-4dannjjm 625 10 greater great JJR cord-023095-4dannjjm 625 11 than than IN cord-023095-4dannjjm 625 12 in in IN cord-023095-4dannjjm 625 13 other other JJ cord-023095-4dannjjm 625 14 tissues tissue NNS cord-023095-4dannjjm 625 15 , , , cord-023095-4dannjjm 625 16 and and CC cord-023095-4dannjjm 625 17 impaired impair VBD cord-023095-4dannjjm 625 18 glucose glucose NN cord-023095-4dannjjm 625 19 uptake uptake NN cord-023095-4dannjjm 625 20 may may MD cord-023095-4dannjjm 625 21 play play VB cord-023095-4dannjjm 625 22 a a DT cord-023095-4dannjjm 625 23 major major JJ cord-023095-4dannjjm 625 24 role role NN cord-023095-4dannjjm 625 25 in in IN cord-023095-4dannjjm 625 26 the the DT cord-023095-4dannjjm 625 27 pathogenesis pathogenesis NN cord-023095-4dannjjm 625 28 of of IN cord-023095-4dannjjm 625 29 heart heart NN cord-023095-4dannjjm 625 30 failure failure NN cord-023095-4dannjjm 625 31 ( ( -LRB- cord-023095-4dannjjm 625 32 HF HF NNP cord-023095-4dannjjm 625 33 ) ) -RRB- cord-023095-4dannjjm 625 34 . . . cord-023095-4dannjjm 626 1 Glucose glucose NN cord-023095-4dannjjm 626 2 uptake uptake NN cord-023095-4dannjjm 626 3 across across IN cord-023095-4dannjjm 626 4 the the DT cord-023095-4dannjjm 626 5 sarcolemma sarcolemma NN cord-023095-4dannjjm 626 6 is be VBZ cord-023095-4dannjjm 626 7 regulated regulate VBN cord-023095-4dannjjm 626 8 by by IN cord-023095-4dannjjm 626 9 a a DT cord-023095-4dannjjm 626 10 family family NN cord-023095-4dannjjm 626 11 of of IN cord-023095-4dannjjm 626 12 membrane membrane NN cord-023095-4dannjjm 626 13 proteins protein NNS cord-023095-4dannjjm 626 14 called call VBD cord-023095-4dannjjm 626 15 glucose glucose NN cord-023095-4dannjjm 626 16 transporters transporter NNS cord-023095-4dannjjm 626 17 ( ( -LRB- cord-023095-4dannjjm 626 18 GLUTs GLUTs NNP cord-023095-4dannjjm 626 19 ) ) -RRB- cord-023095-4dannjjm 626 20 , , , cord-023095-4dannjjm 626 21 which which WDT cord-023095-4dannjjm 626 22 includes include VBZ cord-023095-4dannjjm 626 23 GLUT-4 glut-4 NN cord-023095-4dannjjm 626 24 , , , cord-023095-4dannjjm 626 25 the the DT cord-023095-4dannjjm 626 26 major major JJ cord-023095-4dannjjm 626 27 cardiac cardiac JJ cord-023095-4dannjjm 626 28 isoform isoform NN cord-023095-4dannjjm 626 29 , , , cord-023095-4dannjjm 626 30 and and CC cord-023095-4dannjjm 626 31 GLUT-12 GLUT-12 NNP cord-023095-4dannjjm 626 32 , , , cord-023095-4dannjjm 626 33 a a DT cord-023095-4dannjjm 626 34 recently recently RB cord-023095-4dannjjm 626 35 discovered discover VBN cord-023095-4dannjjm 626 36 isoform isoform NN cord-023095-4dannjjm 626 37 , , , cord-023095-4dannjjm 626 38 the the DT cord-023095-4dannjjm 626 39 role role NN cord-023095-4dannjjm 626 40 of of IN cord-023095-4dannjjm 626 41 which which WDT cord-023095-4dannjjm 626 42 is be VBZ cord-023095-4dannjjm 626 43 unknown unknown JJ cord-023095-4dannjjm 626 44 in in IN cord-023095-4dannjjm 626 45 the the DT cord-023095-4dannjjm 626 46 heart heart NN cord-023095-4dannjjm 626 47 . . . cord-023095-4dannjjm 627 1 In in IN cord-023095-4dannjjm 627 2 addition addition NN cord-023095-4dannjjm 627 3 , , , cord-023095-4dannjjm 627 4 despite despite IN cord-023095-4dannjjm 627 5 the the DT cord-023095-4dannjjm 627 6 wellknown wellknown JJ cord-023095-4dannjjm 627 7 regional regional JJ cord-023095-4dannjjm 627 8 differences difference NNS cord-023095-4dannjjm 627 9 in in IN cord-023095-4dannjjm 627 10 myocardial myocardial JJ cord-023095-4dannjjm 627 11 structure structure NN cord-023095-4dannjjm 627 12 and and CC cord-023095-4dannjjm 627 13 function function NN cord-023095-4dannjjm 627 14 , , , cord-023095-4dannjjm 627 15 potential potential JJ cord-023095-4dannjjm 627 16 regional regional JJ cord-023095-4dannjjm 627 17 patterns pattern NNS cord-023095-4dannjjm 627 18 in in IN cord-023095-4dannjjm 627 19 glucose glucose NN cord-023095-4dannjjm 627 20 transport transport NN cord-023095-4dannjjm 627 21 have have VBP cord-023095-4dannjjm 627 22 not not RB cord-023095-4dannjjm 627 23 been be VBN cord-023095-4dannjjm 627 24 investigated investigate VBN cord-023095-4dannjjm 627 25 . . . cord-023095-4dannjjm 628 1 Thus thus RB cord-023095-4dannjjm 628 2 , , , cord-023095-4dannjjm 628 3 we -PRON- PRP cord-023095-4dannjjm 628 4 hypothesized hypothesize VBD cord-023095-4dannjjm 628 5 that that IN cord-023095-4dannjjm 628 6 GLUT-4 glut-4 NN cord-023095-4dannjjm 628 7 and and CC cord-023095-4dannjjm 628 8 -12 -12 : cord-023095-4dannjjm 628 9 protein protein NN cord-023095-4dannjjm 628 10 and and CC cord-023095-4dannjjm 628 11 gene gene NN cord-023095-4dannjjm 628 12 expression expression NN cord-023095-4dannjjm 628 13 would would MD cord-023095-4dannjjm 628 14 be be VB cord-023095-4dannjjm 628 15 chamber chamber NN cord-023095-4dannjjm 628 16 specific specific JJ cord-023095-4dannjjm 628 17 in in IN cord-023095-4dannjjm 628 18 healthy healthy JJ cord-023095-4dannjjm 628 19 dogs dog NNS cord-023095-4dannjjm 628 20 and and CC cord-023095-4dannjjm 628 21 during during IN cord-023095-4dannjjm 628 22 chronic chronic JJ cord-023095-4dannjjm 628 23 HF HF NNP cord-023095-4dannjjm 628 24 . . . cord-023095-4dannjjm 629 1 Using use VBG cord-023095-4dannjjm 629 2 a a DT cord-023095-4dannjjm 629 3 canine canine JJ cord-023095-4dannjjm 629 4 model model NN cord-023095-4dannjjm 629 5 of of IN cord-023095-4dannjjm 629 6 tachypacing tachypace VBG cord-023095-4dannjjm 629 7 induced induce VBN cord-023095-4dannjjm 629 8 chronic chronic JJ cord-023095-4dannjjm 629 9 HF HF NNP cord-023095-4dannjjm 629 10 , , , cord-023095-4dannjjm 629 11 GLUT glut NN cord-023095-4dannjjm 629 12 protein protein NN cord-023095-4dannjjm 629 13 and and CC cord-023095-4dannjjm 629 14 messenger messenger NN cord-023095-4dannjjm 629 15 RNA RNA NNP cord-023095-4dannjjm 629 16 in in IN cord-023095-4dannjjm 629 17 both both CC cord-023095-4dannjjm 629 18 ventricles ventricle NNS cord-023095-4dannjjm 629 19 and and CC cord-023095-4dannjjm 629 20 atria atria NN cord-023095-4dannjjm 629 21 were be VBD cord-023095-4dannjjm 629 22 investigated investigate VBN cord-023095-4dannjjm 629 23 by by IN cord-023095-4dannjjm 629 24 immunoblotting immunoblotte VBG cord-023095-4dannjjm 629 25 and and CC cord-023095-4dannjjm 629 26 real real JJ cord-023095-4dannjjm 629 27 time time NN cord-023095-4dannjjm 629 28 PCR PCR NNP cord-023095-4dannjjm 629 29 . . . cord-023095-4dannjjm 630 1 In in IN cord-023095-4dannjjm 630 2 control control NN cord-023095-4dannjjm 630 3 dogs dog NNS cord-023095-4dannjjm 630 4 , , , cord-023095-4dannjjm 630 5 GLUT-4 GLUT-4 VBG cord-023095-4dannjjm 630 6 , , , cord-023095-4dannjjm 630 7 but but CC cord-023095-4dannjjm 630 8 not not RB cord-023095-4dannjjm 630 9 GLUT-12 glut-12 CD cord-023095-4dannjjm 630 10 , , , cord-023095-4dannjjm 630 11 protein protein NN cord-023095-4dannjjm 630 12 expression expression NN cord-023095-4dannjjm 630 13 were be VBD cord-023095-4dannjjm 630 14 significantly significantly RB cord-023095-4dannjjm 630 15 higher high JJR cord-023095-4dannjjm 630 16 in in IN cord-023095-4dannjjm 630 17 the the DT cord-023095-4dannjjm 630 18 atria atria NN cord-023095-4dannjjm 630 19 compared compare VBN cord-023095-4dannjjm 630 20 to to IN cord-023095-4dannjjm 630 21 the the DT cord-023095-4dannjjm 630 22 ventricles ventricle NNS cord-023095-4dannjjm 630 23 , , , cord-023095-4dannjjm 630 24 with with IN cord-023095-4dannjjm 630 25 the the DT cord-023095-4dannjjm 630 26 highest high JJS cord-023095-4dannjjm 630 27 content content NN cord-023095-4dannjjm 630 28 in in IN cord-023095-4dannjjm 630 29 the the DT cord-023095-4dannjjm 630 30 right right JJ cord-023095-4dannjjm 630 31 atrium atrium NN cord-023095-4dannjjm 630 32 ( ( -LRB- cord-023095-4dannjjm 630 33 RA RA NNP cord-023095-4dannjjm 630 34 , , , cord-023095-4dannjjm 630 35 P p NN cord-023095-4dannjjm 630 36 o o NN cord-023095-4dannjjm 630 37 0.001 0.001 CD cord-023095-4dannjjm 630 38 ) ) -RRB- cord-023095-4dannjjm 630 39 . . . cord-023095-4dannjjm 631 1 GLUT-4 glut-4 NN cord-023095-4dannjjm 631 2 and and CC cord-023095-4dannjjm 631 3 -12 -12 . cord-023095-4dannjjm 632 1 mRNA mRNA NNP cord-023095-4dannjjm 632 2 were be VBD cord-023095-4dannjjm 632 3 homogeneously homogeneously RB cord-023095-4dannjjm 632 4 expressed express VBN cord-023095-4dannjjm 632 5 in in IN cord-023095-4dannjjm 632 6 all all PDT cord-023095-4dannjjm 632 7 the the DT cord-023095-4dannjjm 632 8 cardiac cardiac JJ cord-023095-4dannjjm 632 9 chambers chamber NNS cord-023095-4dannjjm 632 10 . . . cord-023095-4dannjjm 633 1 During during IN cord-023095-4dannjjm 633 2 chronic chronic JJ cord-023095-4dannjjm 633 3 HF HF NNP cord-023095-4dannjjm 633 4 , , , cord-023095-4dannjjm 633 5 GLUT glut NN cord-023095-4dannjjm 633 6 -4 -4 NNS cord-023095-4dannjjm 633 7 and and CC cord-023095-4dannjjm 633 8 -12 -12 CD cord-023095-4dannjjm 633 9 expression expression NN cord-023095-4dannjjm 633 10 was be VBD cord-023095-4dannjjm 633 11 highest high JJS cord-023095-4dannjjm 633 12 in in IN cord-023095-4dannjjm 633 13 the the DT cord-023095-4dannjjm 633 14 left left JJ cord-023095-4dannjjm 633 15 ventricle ventricle NN cord-023095-4dannjjm 633 16 ( ( -LRB- cord-023095-4dannjjm 633 17 LV LV NNP cord-023095-4dannjjm 633 18 , , , cord-023095-4dannjjm 633 19 by by IN cord-023095-4dannjjm 633 20 2.5 2.5 CD cord-023095-4dannjjm 633 21 and and CC cord-023095-4dannjjm 633 22 4.2 4.2 CD cord-023095-4dannjjm 633 23 fold fold VB cord-023095-4dannjjm 633 24 , , , cord-023095-4dannjjm 633 25 respectively respectively RB cord-023095-4dannjjm 633 26 , , , cord-023095-4dannjjm 633 27 P p NN cord-023095-4dannjjm 633 28 o o NN cord-023095-4dannjjm 633 29 0.01 0.01 CD cord-023095-4dannjjm 633 30 ) ) -RRB- cord-023095-4dannjjm 633 31 , , , cord-023095-4dannjjm 633 32 with with IN cord-023095-4dannjjm 633 33 a a DT cord-023095-4dannjjm 633 34 concomitant concomitant JJ cord-023095-4dannjjm 633 35 increase increase NN cord-023095-4dannjjm 633 36 in in IN cord-023095-4dannjjm 633 37 GLUT-4 GLUT-4 NNP cord-023095-4dannjjm 633 38 and and CC cord-023095-4dannjjm 633 39 -12 -12 : cord-023095-4dannjjm 633 40 mRNA mRNA NNP cord-023095-4dannjjm 633 41 ( ( -LRB- cord-023095-4dannjjm 633 42 P p NN cord-023095-4dannjjm 633 43 o o NN cord-023095-4dannjjm 633 44 0.001 0.001 CD cord-023095-4dannjjm 633 45 ) ) -RRB- cord-023095-4dannjjm 633 46 . . . cord-023095-4dannjjm 634 1 GLUT glut NN cord-023095-4dannjjm 634 2 -4 -4 XX cord-023095-4dannjjm 634 3 , , , cord-023095-4dannjjm 634 4 but but CC cord-023095-4dannjjm 634 5 not not RB cord-023095-4dannjjm 634 6 GLUT-12 glut-12 CD cord-023095-4dannjjm 634 7 , , , cord-023095-4dannjjm 634 8 was be VBD cord-023095-4dannjjm 634 9 decreased decrease VBN cord-023095-4dannjjm 634 10 in in IN cord-023095-4dannjjm 634 11 RA RA NNP cord-023095-4dannjjm 634 12 during during IN cord-023095-4dannjjm 634 13 chronic chronic JJ cord-023095-4dannjjm 634 14 HF HF NNP cord-023095-4dannjjm 634 15 ( ( -LRB- cord-023095-4dannjjm 634 16 P p NN cord-023095-4dannjjm 634 17 5 5 CD cord-023095-4dannjjm 634 18 0.001 0.001 CD cord-023095-4dannjjm 634 19 ) ) -RRB- cord-023095-4dannjjm 634 20 . . . cord-023095-4dannjjm 635 1 Our -PRON- PRP$ cord-023095-4dannjjm 635 2 data datum NNS cord-023095-4dannjjm 635 3 suggest suggest VBP cord-023095-4dannjjm 635 4 that that IN cord-023095-4dannjjm 635 5 GLUT-4 GLUT-4 NNP cord-023095-4dannjjm 635 6 protein protein NN cord-023095-4dannjjm 635 7 was be VBD cord-023095-4dannjjm 635 8 differentially differentially RB cord-023095-4dannjjm 635 9 expressed express VBN cord-023095-4dannjjm 635 10 across across IN cord-023095-4dannjjm 635 11 the the DT cord-023095-4dannjjm 635 12 cardiac cardiac JJ cord-023095-4dannjjm 635 13 chambers chamber NNS cord-023095-4dannjjm 635 14 in in IN cord-023095-4dannjjm 635 15 the the DT cord-023095-4dannjjm 635 16 healthy healthy JJ cord-023095-4dannjjm 635 17 heart heart NN cord-023095-4dannjjm 635 18 . . . cord-023095-4dannjjm 636 1 During during IN cord-023095-4dannjjm 636 2 chronic chronic JJ cord-023095-4dannjjm 636 3 HF HF NNP cord-023095-4dannjjm 636 4 , , , cord-023095-4dannjjm 636 5 LV LV NNP cord-023095-4dannjjm 636 6 was be VBD cord-023095-4dannjjm 636 7 the the DT cord-023095-4dannjjm 636 8 primary primary JJ cord-023095-4dannjjm 636 9 site site NN cord-023095-4dannjjm 636 10 dependent dependent JJ cord-023095-4dannjjm 636 11 on on IN cord-023095-4dannjjm 636 12 both both DT cord-023095-4dannjjm 636 13 GLUT4and GLUT4and NNP cord-023095-4dannjjm 636 14 GLUT12-mediated glut12-mediated JJ cord-023095-4dannjjm 636 15 glucose glucose NN cord-023095-4dannjjm 636 16 transport transport NN cord-023095-4dannjjm 636 17 , , , cord-023095-4dannjjm 636 18 which which WDT cord-023095-4dannjjm 636 19 was be VBD cord-023095-4dannjjm 636 20 transcriptionally transcriptionally RB cord-023095-4dannjjm 636 21 regulated regulate VBN cord-023095-4dannjjm 636 22 . . . cord-023095-4dannjjm 637 1 In in IN cord-023095-4dannjjm 637 2 addition addition NN cord-023095-4dannjjm 637 3 , , , cord-023095-4dannjjm 637 4 the the DT cord-023095-4dannjjm 637 5 paradoxical paradoxical JJ cord-023095-4dannjjm 637 6 decrease decrease NN cord-023095-4dannjjm 637 7 in in IN cord-023095-4dannjjm 637 8 GLUT4 GLUT4 NNP cord-023095-4dannjjm 637 9 content content NN cord-023095-4dannjjm 637 10 in in IN cord-023095-4dannjjm 637 11 RA RA NNP cord-023095-4dannjjm 637 12 may may MD cord-023095-4dannjjm 637 13 induce induce VB cord-023095-4dannjjm 637 14 perturbations perturbation NNS cord-023095-4dannjjm 637 15 in in IN cord-023095-4dannjjm 637 16 atrial atrial JJ cord-023095-4dannjjm 637 17 energy energy NN cord-023095-4dannjjm 637 18 production production NN cord-023095-4dannjjm 637 19 during during IN cord-023095-4dannjjm 637 20 chronic chronic JJ cord-023095-4dannjjm 637 21 HF HF NNP cord-023095-4dannjjm 637 22 . . . cord-023095-4dannjjm 638 1 Some some DT cord-023095-4dannjjm 638 2 obese obese JJ cord-023095-4dannjjm 638 3 dogs dog NNS cord-023095-4dannjjm 638 4 are be VBP cord-023095-4dannjjm 638 5 suspected suspect VBN cord-023095-4dannjjm 638 6 to to TO cord-023095-4dannjjm 638 7 have have VB cord-023095-4dannjjm 638 8 cardiac cardiac JJ cord-023095-4dannjjm 638 9 disease disease NN cord-023095-4dannjjm 638 10 because because IN cord-023095-4dannjjm 638 11 they -PRON- PRP cord-023095-4dannjjm 638 12 have have VBP cord-023095-4dannjjm 638 13 enlargement enlargement NN cord-023095-4dannjjm 638 14 of of IN cord-023095-4dannjjm 638 15 the the DT cord-023095-4dannjjm 638 16 heart heart NN cord-023095-4dannjjm 638 17 on on IN cord-023095-4dannjjm 638 18 thoracic thoracic JJ cord-023095-4dannjjm 638 19 radiograph radiograph NN cord-023095-4dannjjm 638 20 . . . cord-023095-4dannjjm 639 1 It -PRON- PRP cord-023095-4dannjjm 639 2 has have VBZ cord-023095-4dannjjm 639 3 been be VBN cord-023095-4dannjjm 639 4 reported report VBN cord-023095-4dannjjm 639 5 in in IN cord-023095-4dannjjm 639 6 cats cat NNS cord-023095-4dannjjm 639 7 that that IN cord-023095-4dannjjm 639 8 the the DT cord-023095-4dannjjm 639 9 fat fat NN cord-023095-4dannjjm 639 10 increases increase VBZ cord-023095-4dannjjm 639 11 the the DT cord-023095-4dannjjm 639 12 cardiac cardiac JJ cord-023095-4dannjjm 639 13 silhouette silhouette NN cord-023095-4dannjjm 639 14 , , , cord-023095-4dannjjm 639 15 while while IN cord-023095-4dannjjm 639 16 echocardiograms echocardiograms NNP cord-023095-4dannjjm 639 17 revealed reveal VBD cord-023095-4dannjjm 639 18 normal normal JJ cord-023095-4dannjjm 639 19 cardiac cardiac JJ cord-023095-4dannjjm 639 20 dimensions dimension NNS cord-023095-4dannjjm 639 21 . . . cord-023095-4dannjjm 640 1 The the DT cord-023095-4dannjjm 640 2 purpose purpose NN cord-023095-4dannjjm 640 3 of of IN cord-023095-4dannjjm 640 4 this this DT cord-023095-4dannjjm 640 5 study study NN cord-023095-4dannjjm 640 6 was be VBD cord-023095-4dannjjm 640 7 to to TO cord-023095-4dannjjm 640 8 determine determine VB cord-023095-4dannjjm 640 9 whether whether IN cord-023095-4dannjjm 640 10 obesity obesity NN cord-023095-4dannjjm 640 11 overestimates overestimate VBZ cord-023095-4dannjjm 640 12 cardiac cardiac JJ cord-023095-4dannjjm 640 13 dimension dimension NN cord-023095-4dannjjm 640 14 in in IN cord-023095-4dannjjm 640 15 radiographs radiograph NNS cord-023095-4dannjjm 640 16 compared compare VBN cord-023095-4dannjjm 640 17 to to IN cord-023095-4dannjjm 640 18 echocardiographic echocardiographic JJ cord-023095-4dannjjm 640 19 findings finding NNS cord-023095-4dannjjm 640 20 in in IN cord-023095-4dannjjm 640 21 dogs dog NNS cord-023095-4dannjjm 640 22 . . . cord-023095-4dannjjm 641 1 Twenty twenty CD cord-023095-4dannjjm 641 2 three three CD cord-023095-4dannjjm 641 3 obese obese JJ cord-023095-4dannjjm 641 4 dogs dog NNS cord-023095-4dannjjm 641 5 and and CC cord-023095-4dannjjm 641 6 20 20 CD cord-023095-4dannjjm 641 7 controls control NNS cord-023095-4dannjjm 641 8 were be VBD cord-023095-4dannjjm 641 9 included include VBN cord-023095-4dannjjm 641 10 based base VBN cord-023095-4dannjjm 641 11 on on IN cord-023095-4dannjjm 641 12 a a DT cord-023095-4dannjjm 641 13 1 1 CD cord-023095-4dannjjm 641 14 - - SYM cord-023095-4dannjjm 641 15 9 9 CD cord-023095-4dannjjm 641 16 body body NN cord-023095-4dannjjm 641 17 condition condition NN cord-023095-4dannjjm 641 18 scoring scoring NN cord-023095-4dannjjm 641 19 ( ( -LRB- cord-023095-4dannjjm 641 20 BCS BCS NNP cord-023095-4dannjjm 641 21 ) ) -RRB- cord-023095-4dannjjm 641 22 . . . cord-023095-4dannjjm 642 1 Computerized computerized JJ cord-023095-4dannjjm 642 2 radiography radiography NN cord-023095-4dannjjm 642 3 was be VBD cord-023095-4dannjjm 642 4 obtained obtain VBN cord-023095-4dannjjm 642 5 and and CC cord-023095-4dannjjm 642 6 VHS VHS NNP cord-023095-4dannjjm 642 7 measurement measurement NN cord-023095-4dannjjm 642 8 was be VBD cord-023095-4dannjjm 642 9 performed perform VBN cord-023095-4dannjjm 642 10 as as IN cord-023095-4dannjjm 642 11 previously previously RB cord-023095-4dannjjm 642 12 described describe VBN cord-023095-4dannjjm 642 13 . . . cord-023095-4dannjjm 643 1 Echocardiographic echocardiographic JJ cord-023095-4dannjjm 643 2 measurements measurement NNS cord-023095-4dannjjm 643 3 were be VBD cord-023095-4dannjjm 643 4 interpreted interpret VBN cord-023095-4dannjjm 643 5 based base VBN cord-023095-4dannjjm 643 6 on on IN cord-023095-4dannjjm 643 7 reference reference NN cord-023095-4dannjjm 643 8 values value NNS cord-023095-4dannjjm 643 9 according accord VBG cord-023095-4dannjjm 643 10 to to IN cord-023095-4dannjjm 643 11 lean lean JJ cord-023095-4dannjjm 643 12 body body NN cord-023095-4dannjjm 643 13 weight weight NN cord-023095-4dannjjm 643 14 regression regression NN cord-023095-4dannjjm 643 15 equations equation NNS cord-023095-4dannjjm 643 16 . . . cord-023095-4dannjjm 644 1 Results result NNS cord-023095-4dannjjm 644 2 for for IN cord-023095-4dannjjm 644 3 echo echo NN cord-023095-4dannjjm 644 4 and and CC cord-023095-4dannjjm 644 5 VHS vhs NN cord-023095-4dannjjm 644 6 measurements measurement NNS cord-023095-4dannjjm 644 7 were be VBD cord-023095-4dannjjm 644 8 classified classify VBN cord-023095-4dannjjm 644 9 in in IN cord-023095-4dannjjm 644 10 scores score NNS cord-023095-4dannjjm 644 11 as as IN cord-023095-4dannjjm 644 12 normal normal JJ cord-023095-4dannjjm 644 13 , , , cord-023095-4dannjjm 644 14 mild mild JJ cord-023095-4dannjjm 644 15 , , , cord-023095-4dannjjm 644 16 moderate moderate JJ cord-023095-4dannjjm 644 17 or or CC cord-023095-4dannjjm 644 18 severe severe JJ cord-023095-4dannjjm 644 19 increase increase NN cord-023095-4dannjjm 644 20 . . . cord-023095-4dannjjm 645 1 Student student NN cord-023095-4dannjjm 645 2 's 's POS cord-023095-4dannjjm 645 3 t t NN cord-023095-4dannjjm 645 4 test test NN cord-023095-4dannjjm 645 5 was be VBD cord-023095-4dannjjm 645 6 used use VBN cord-023095-4dannjjm 645 7 for for IN cord-023095-4dannjjm 645 8 comparison comparison NN cord-023095-4dannjjm 645 9 of of IN cord-023095-4dannjjm 645 10 VHS vhs NN cord-023095-4dannjjm 645 11 between between IN cord-023095-4dannjjm 645 12 groups group NNS cord-023095-4dannjjm 645 13 . . . cord-023095-4dannjjm 646 1 Mann Mann NNP cord-023095-4dannjjm 646 2 - - HYPH cord-023095-4dannjjm 646 3 Whitney Whitney NNP cord-023095-4dannjjm 646 4 Rank Rank NNP cord-023095-4dannjjm 646 5 Sum Sum NNP cord-023095-4dannjjm 646 6 test test NN cord-023095-4dannjjm 646 7 was be VBD cord-023095-4dannjjm 646 8 used use VBN cord-023095-4dannjjm 646 9 to to TO cord-023095-4dannjjm 646 10 assess assess VB cord-023095-4dannjjm 646 11 echocardiographic echocardiographic JJ cord-023095-4dannjjm 646 12 scores score NNS cord-023095-4dannjjm 646 13 between between IN cord-023095-4dannjjm 646 14 groups group NNS cord-023095-4dannjjm 646 15 . . . cord-023095-4dannjjm 647 1 Spearman Spearman NNP cord-023095-4dannjjm 647 2 Rank Rank NNP cord-023095-4dannjjm 647 3 Order Order NNP cord-023095-4dannjjm 647 4 Correlation Correlation NNP cord-023095-4dannjjm 647 5 was be VBD cord-023095-4dannjjm 647 6 used use VBN cord-023095-4dannjjm 647 7 to to TO cord-023095-4dannjjm 647 8 assess assess VB cord-023095-4dannjjm 647 9 relationships relationship NNS cord-023095-4dannjjm 647 10 between between IN cord-023095-4dannjjm 647 11 any any DT cord-023095-4dannjjm 647 12 pairs pair NNS cord-023095-4dannjjm 647 13 of of IN cord-023095-4dannjjm 647 14 variables variable NNS cord-023095-4dannjjm 647 15 between between IN cord-023095-4dannjjm 647 16 echo echo NN cord-023095-4dannjjm 647 17 and and CC cord-023095-4dannjjm 647 18 VHS VHS NNP cord-023095-4dannjjm 647 19 scores score NNS cord-023095-4dannjjm 647 20 , , , cord-023095-4dannjjm 647 21 echo echo VBP cord-023095-4dannjjm 647 22 vs vs IN cord-023095-4dannjjm 647 23 BCS BCS NNP cord-023095-4dannjjm 647 24 and and CC cord-023095-4dannjjm 647 25 VHS VHS NNP cord-023095-4dannjjm 647 26 vs vs IN cord-023095-4dannjjm 647 27 BCS BCS NNP cord-023095-4dannjjm 647 28 . . . cord-023095-4dannjjm 648 1 Groups group NNS cord-023095-4dannjjm 648 2 were be VBD cord-023095-4dannjjm 648 3 similar similar JJ cord-023095-4dannjjm 648 4 regarding regard VBG cord-023095-4dannjjm 648 5 age age NN cord-023095-4dannjjm 648 6 [ [ -LRB- cord-023095-4dannjjm 648 7 obese obese JJ cord-023095-4dannjjm 648 8 ( ( -LRB- cord-023095-4dannjjm 648 9 69AE24 69ae24 NN cord-023095-4dannjjm 648 10 ) ) -RRB- cord-023095-4dannjjm 648 11 ; ; : cord-023095-4dannjjm 648 12 control control NN cord-023095-4dannjjm 648 13 ( ( -LRB- cord-023095-4dannjjm 648 14 62AE27 62ae27 NN cord-023095-4dannjjm 648 15 ) ) -RRB- cord-023095-4dannjjm 648 16 ; ; : cord-023095-4dannjjm 648 17 P p NN cord-023095-4dannjjm 648 18 5 5 CD cord-023095-4dannjjm 648 19 0.368 0.368 CD cord-023095-4dannjjm 648 20 ] ] -RRB- cord-023095-4dannjjm 648 21 , , , cord-023095-4dannjjm 648 22 breeds breed NNS cord-023095-4dannjjm 648 23 and and CC cord-023095-4dannjjm 648 24 gender gender NN cord-023095-4dannjjm 648 25 distribution distribution NN cord-023095-4dannjjm 648 26 . . . cord-023095-4dannjjm 649 1 Obese obese JJ cord-023095-4dannjjm 649 2 dogs dog NNS cord-023095-4dannjjm 649 3 had have VBD cord-023095-4dannjjm 649 4 significantly significantly RB cord-023095-4dannjjm 649 5 higher high JJR cord-023095-4dannjjm 649 6 VHS vhs NN cord-023095-4dannjjm 649 7 and and CC cord-023095-4dannjjm 649 8 echo echo NN cord-023095-4dannjjm 649 9 scores score NNS cord-023095-4dannjjm 649 10 compared compare VBN cord-023095-4dannjjm 649 11 with with IN cord-023095-4dannjjm 649 12 controls control NNS cord-023095-4dannjjm 649 13 [ [ -LRB- cord-023095-4dannjjm 649 14 VHS vhs NN cord-023095-4dannjjm 649 15 : : : cord-023095-4dannjjm 649 16 ( ( -LRB- cord-023095-4dannjjm 649 17 10.58AE0.69 10.58ae0.69 CD cord-023095-4dannjjm 649 18 ) ) -RRB- cord-023095-4dannjjm 649 19 vs vs IN cord-023095-4dannjjm 649 20 ( ( -LRB- cord-023095-4dannjjm 649 21 9.77AE0.54 9.77ae0.54 CD cord-023095-4dannjjm 649 22 ) ) -RRB- cord-023095-4dannjjm 649 23 ; ; : cord-023095-4dannjjm 650 1 P p NN cord-023095-4dannjjm 650 2 o o NN cord-023095-4dannjjm 650 3 0.001 0.001 CD cord-023095-4dannjjm 650 4 ; ; : cord-023095-4dannjjm 650 5 Echo Echo NNP cord-023095-4dannjjm 650 6 score score NN cord-023095-4dannjjm 650 7 : : : cord-023095-4dannjjm 650 8 range range NN cord-023095-4dannjjm 650 9 ( ( -LRB- cord-023095-4dannjjm 650 10 1 1 CD cord-023095-4dannjjm 650 11 - - SYM cord-023095-4dannjjm 650 12 4 4 CD cord-023095-4dannjjm 650 13 ) ) -RRB- cord-023095-4dannjjm 651 1 vs vs IN cord-023095-4dannjjm 651 2 ( ( -LRB- cord-023095-4dannjjm 651 3 1 1 CD cord-023095-4dannjjm 651 4 - - SYM cord-023095-4dannjjm 651 5 2 2 CD cord-023095-4dannjjm 651 6 ) ) -RRB- cord-023095-4dannjjm 651 7 ; ; : cord-023095-4dannjjm 651 8 P p NN cord-023095-4dannjjm 651 9 4 4 CD cord-023095-4dannjjm 651 10 0.05 0.05 CD cord-023095-4dannjjm 651 11 ] ] -RRB- cord-023095-4dannjjm 651 12 . . . cord-023095-4dannjjm 652 1 There there EX cord-023095-4dannjjm 652 2 were be VBD cord-023095-4dannjjm 652 3 no no DT cord-023095-4dannjjm 652 4 relationships relationship NNS cord-023095-4dannjjm 652 5 between between IN cord-023095-4dannjjm 652 6 any any DT cord-023095-4dannjjm 652 7 pair pair NN cord-023095-4dannjjm 652 8 of of IN cord-023095-4dannjjm 652 9 variables variable NNS cord-023095-4dannjjm 652 10 analyzed analyze VBN cord-023095-4dannjjm 652 11 . . . cord-023095-4dannjjm 653 1 These these DT cord-023095-4dannjjm 653 2 results result NNS cord-023095-4dannjjm 653 3 show show VBP cord-023095-4dannjjm 653 4 that that IN cord-023095-4dannjjm 653 5 there there EX cord-023095-4dannjjm 653 6 are be VBP cord-023095-4dannjjm 653 7 changes change NNS cord-023095-4dannjjm 653 8 both both DT cord-023095-4dannjjm 653 9 in in IN cord-023095-4dannjjm 653 10 echo echo NN cord-023095-4dannjjm 653 11 and and CC cord-023095-4dannjjm 653 12 radiographic radiographic JJ cord-023095-4dannjjm 653 13 appearance appearance NN cord-023095-4dannjjm 653 14 of of IN cord-023095-4dannjjm 653 15 the the DT cord-023095-4dannjjm 653 16 heart heart NN cord-023095-4dannjjm 653 17 in in IN cord-023095-4dannjjm 653 18 obese obese JJ cord-023095-4dannjjm 653 19 dogs dog NNS cord-023095-4dannjjm 653 20 , , , cord-023095-4dannjjm 653 21 but but CC cord-023095-4dannjjm 653 22 VHS VHS NNP cord-023095-4dannjjm 653 23 overestimates overestimate VBZ cord-023095-4dannjjm 653 24 cardiac cardiac JJ cord-023095-4dannjjm 653 25 silhouette silhouette NN cord-023095-4dannjjm 653 26 compared compare VBN cord-023095-4dannjjm 653 27 to to TO cord-023095-4dannjjm 653 28 echo echo VB cord-023095-4dannjjm 653 29 , , , cord-023095-4dannjjm 653 30 probably probably RB cord-023095-4dannjjm 653 31 related relate VBD cord-023095-4dannjjm 653 32 to to IN cord-023095-4dannjjm 653 33 pericardial pericardial JJ cord-023095-4dannjjm 653 34 fat fat JJ cord-023095-4dannjjm 653 35 accumulation accumulation NN cord-023095-4dannjjm 653 36 . . . cord-023095-4dannjjm 654 1 Heart heart NN cord-023095-4dannjjm 654 2 rate rate NN cord-023095-4dannjjm 654 3 variability variability NN cord-023095-4dannjjm 654 4 ( ( -LRB- cord-023095-4dannjjm 654 5 HRV HRV NNP cord-023095-4dannjjm 654 6 ) ) -RRB- cord-023095-4dannjjm 654 7 is be VBZ cord-023095-4dannjjm 654 8 an an DT cord-023095-4dannjjm 654 9 indirect indirect JJ cord-023095-4dannjjm 654 10 measurement measurement NN cord-023095-4dannjjm 654 11 of of IN cord-023095-4dannjjm 654 12 the the DT cord-023095-4dannjjm 654 13 autonomic autonomic JJ cord-023095-4dannjjm 654 14 modulation modulation NN cord-023095-4dannjjm 654 15 of of IN cord-023095-4dannjjm 654 16 heart heart NN cord-023095-4dannjjm 654 17 rate rate NN cord-023095-4dannjjm 654 18 ( ( -LRB- cord-023095-4dannjjm 654 19 HR HR NNP cord-023095-4dannjjm 654 20 ) ) -RRB- cord-023095-4dannjjm 654 21 . . . cord-023095-4dannjjm 655 1 Reduced reduce VBN cord-023095-4dannjjm 655 2 HRV HRV NNP cord-023095-4dannjjm 655 3 measured measure VBN cord-023095-4dannjjm 655 4 from from IN cord-023095-4dannjjm 655 5 short short JJ cord-023095-4dannjjm 655 6 - - HYPH cord-023095-4dannjjm 655 7 time time NN cord-023095-4dannjjm 655 8 electrocardiography electrocardiography NN cord-023095-4dannjjm 655 9 is be VBZ cord-023095-4dannjjm 655 10 seen see VBN cord-023095-4dannjjm 655 11 in in IN cord-023095-4dannjjm 655 12 dogs dog NNS cord-023095-4dannjjm 655 13 with with IN cord-023095-4dannjjm 655 14 heart heart NN cord-023095-4dannjjm 655 15 failure failure NN cord-023095-4dannjjm 655 16 ( ( -LRB- cord-023095-4dannjjm 655 17 HF HF NNP cord-023095-4dannjjm 655 18 ) ) -RRB- cord-023095-4dannjjm 655 19 secondary secondary JJ cord-023095-4dannjjm 655 20 to to IN cord-023095-4dannjjm 655 21 myxomatous myxomatous JJ cord-023095-4dannjjm 655 22 mitral mitral JJ cord-023095-4dannjjm 655 23 valve valve NN cord-023095-4dannjjm 655 24 disease disease NN cord-023095-4dannjjm 655 25 ( ( -LRB- cord-023095-4dannjjm 655 26 MMVD MMVD NNP cord-023095-4dannjjm 655 27 ) ) -RRB- cord-023095-4dannjjm 655 28 . . . cord-023095-4dannjjm 656 1 However however RB cord-023095-4dannjjm 656 2 , , , cord-023095-4dannjjm 656 3 HRV HRV NNP cord-023095-4dannjjm 656 4 is be VBZ cord-023095-4dannjjm 656 5 suggested suggest VBN cord-023095-4dannjjm 656 6 to to TO cord-023095-4dannjjm 656 7 increase increase VB cord-023095-4dannjjm 656 8 with with IN cord-023095-4dannjjm 656 9 disease disease NN cord-023095-4dannjjm 656 10 severity severity NN cord-023095-4dannjjm 656 11 at at IN cord-023095-4dannjjm 656 12 early early JJ cord-023095-4dannjjm 656 13 stages stage NNS cord-023095-4dannjjm 656 14 of of IN cord-023095-4dannjjm 656 15 MMVD MMVD NNP cord-023095-4dannjjm 656 16 . . . cord-023095-4dannjjm 657 1 The the DT cord-023095-4dannjjm 657 2 aims aim NNS cord-023095-4dannjjm 657 3 of of IN cord-023095-4dannjjm 657 4 this this DT cord-023095-4dannjjm 657 5 study study NN cord-023095-4dannjjm 657 6 were be VBD cord-023095-4dannjjm 657 7 1 1 CD cord-023095-4dannjjm 657 8 ) ) -RRB- cord-023095-4dannjjm 657 9 to to TO cord-023095-4dannjjm 657 10 associate associate VB cord-023095-4dannjjm 657 11 HR HR NNP cord-023095-4dannjjm 657 12 and and CC cord-023095-4dannjjm 657 13 HRV HRV NNP cord-023095-4dannjjm 657 14 with with IN cord-023095-4dannjjm 657 15 severity severity NN cord-023095-4dannjjm 657 16 of of IN cord-023095-4dannjjm 657 17 MMVD MMVD NNP cord-023095-4dannjjm 657 18 in in IN cord-023095-4dannjjm 657 19 Cavalier Cavalier NNP cord-023095-4dannjjm 657 20 King King NNP cord-023095-4dannjjm 657 21 Charles Charles NNP cord-023095-4dannjjm 657 22 Spaniels Spaniels NNPS cord-023095-4dannjjm 658 1 ( ( -LRB- cord-023095-4dannjjm 658 2 CKCS CKCS NNP cord-023095-4dannjjm 658 3 ) ) -RRB- cord-023095-4dannjjm 658 4 and and CC cord-023095-4dannjjm 658 5 2 2 LS cord-023095-4dannjjm 658 6 ) ) -RRB- cord-023095-4dannjjm 659 1 to to TO cord-023095-4dannjjm 659 2 compare compare VB cord-023095-4dannjjm 659 3 HR HR NNP cord-023095-4dannjjm 659 4 and and CC cord-023095-4dannjjm 659 5 HRV HRV NNP cord-023095-4dannjjm 659 6 between between IN cord-023095-4dannjjm 659 7 CKCS CKCS NNP cord-023095-4dannjjm 659 8 and and CC cord-023095-4dannjjm 659 9 other other JJ cord-023095-4dannjjm 659 10 dog dog NN cord-023095-4dannjjm 659 11 breeds breed NNS cord-023095-4dannjjm 659 12 in in IN cord-023095-4dannjjm 659 13 a a DT cord-023095-4dannjjm 659 14 group group NN cord-023095-4dannjjm 659 15 of of IN cord-023095-4dannjjm 659 16 dogs dog NNS cord-023095-4dannjjm 659 17 in in IN cord-023095-4dannjjm 659 18 HF HF NNP cord-023095-4dannjjm 659 19 secondary secondary JJ cord-023095-4dannjjm 659 20 to to IN cord-023095-4dannjjm 659 21 MMVD MMVD NNP cord-023095-4dannjjm 659 22 . . . cord-023095-4dannjjm 660 1 One one CD cord-023095-4dannjjm 660 2 - - HYPH cord-023095-4dannjjm 660 3 hundred hundred CD cord-023095-4dannjjm 660 4 dogs dog NNS cord-023095-4dannjjm 660 5 were be VBD cord-023095-4dannjjm 660 6 examined examine VBN cord-023095-4dannjjm 660 7 by by IN cord-023095-4dannjjm 660 8 echocardiography echocardiography NN cord-023095-4dannjjm 660 9 and and CC cord-023095-4dannjjm 660 10 24hour 24hour JJ cord-023095-4dannjjm 660 11 electrocardiography electrocardiography NN cord-023095-4dannjjm 660 12 . . . cord-023095-4dannjjm 661 1 The the DT cord-023095-4dannjjm 661 2 dogs dog NNS cord-023095-4dannjjm 661 3 were be VBD cord-023095-4dannjjm 661 4 divided divide VBN cord-023095-4dannjjm 661 5 into into IN cord-023095-4dannjjm 661 6 five five CD cord-023095-4dannjjm 661 7 groups group NNS cord-023095-4dannjjm 661 8 : : : cord-023095-4dannjjm 662 1 1 1 LS cord-023095-4dannjjm 662 2 ) ) -RRB- cord-023095-4dannjjm 662 3 CKCS ckcs NN cord-023095-4dannjjm 662 4 with with IN cord-023095-4dannjjm 662 5 no no DT cord-023095-4dannjjm 662 6 / / SYM cord-023095-4dannjjm 662 7 minimal minimal JJ cord-023095-4dannjjm 662 8 mitral mitral JJ cord-023095-4dannjjm 662 9 regurgitation regurgitation NN cord-023095-4dannjjm 662 10 ( ( -LRB- cord-023095-4dannjjm 662 11 MR MR NNP cord-023095-4dannjjm 662 12 ) ) -RRB- cord-023095-4dannjjm 662 13 ( ( -LRB- cord-023095-4dannjjm 662 14 MR MR NNP cord-023095-4dannjjm 662 15 jet jet NN cord-023095-4dannjjm 662 16 15 15 CD cord-023095-4dannjjm 662 17 % % NN cord-023095-4dannjjm 662 18 of of IN cord-023095-4dannjjm 662 19 the the DT cord-023095-4dannjjm 662 20 left left JJ cord-023095-4dannjjm 662 21 atrial atrial JJ cord-023095-4dannjjm 662 22 area area NN cord-023095-4dannjjm 662 23 using use VBG cord-023095-4dannjjm 662 24 color color NN cord-023095-4dannjjm 662 25 Doppler Doppler NNP cord-023095-4dannjjm 662 26 mapping mapping NN cord-023095-4dannjjm 662 27 ) ) -RRB- cord-023095-4dannjjm 662 28 and and CC cord-023095-4dannjjm 662 29 no no DT cord-023095-4dannjjm 662 30 murmur murmur NN cord-023095-4dannjjm 662 31 , , , cord-023095-4dannjjm 662 32 2 2 CD cord-023095-4dannjjm 662 33 ) ) -RRB- cord-023095-4dannjjm 663 1 CKCS CKCS NNP cord-023095-4dannjjm 663 2 with with IN cord-023095-4dannjjm 663 3 mild mild JJ cord-023095-4dannjjm 663 4 MR MR NNP cord-023095-4dannjjm 663 5 ( ( -LRB- cord-023095-4dannjjm 663 6 20 20 CD cord-023095-4dannjjm 663 7 % % NN cord-023095-4dannjjm 664 1 o o UH cord-023095-4dannjjm 664 2 jet jet NN cord-023095-4dannjjm 664 3 50 50 CD cord-023095-4dannjjm 664 4 % % NN cord-023095-4dannjjm 664 5 ) ) -RRB- cord-023095-4dannjjm 664 6 , , . cord-023095-4dannjjm 665 1 3 3 LS cord-023095-4dannjjm 665 2 ) ) -RRB- cord-023095-4dannjjm 665 3 CKCS CKCS NNP cord-023095-4dannjjm 665 4 with with IN cord-023095-4dannjjm 665 5 moderate/ moderate/ CD cord-023095-4dannjjm 666 1 severe severe JJ cord-023095-4dannjjm 666 2 MR MR NNP cord-023095-4dannjjm 666 3 ( ( -LRB- cord-023095-4dannjjm 666 4 jet450 jet450 NNP cord-023095-4dannjjm 666 5 % % NN cord-023095-4dannjjm 666 6 ) ) -RRB- cord-023095-4dannjjm 666 7 and and CC cord-023095-4dannjjm 666 8 no no DT cord-023095-4dannjjm 666 9 clinical clinical JJ cord-023095-4dannjjm 666 10 signs sign NNS cord-023095-4dannjjm 666 11 of of IN cord-023095-4dannjjm 666 12 HF HF NNP cord-023095-4dannjjm 666 13 , , , cord-023095-4dannjjm 666 14 4 4 CD cord-023095-4dannjjm 666 15 ) ) -RRB- cord-023095-4dannjjm 667 1 CKCS CKCS NNP cord-023095-4dannjjm 667 2 in in IN cord-023095-4dannjjm 667 3 HF HF NNP cord-023095-4dannjjm 667 4 ( ( -LRB- cord-023095-4dannjjm 667 5 HF HF NNP cord-023095-4dannjjm 667 6 defined define VBN cord-023095-4dannjjm 667 7 as as IN cord-023095-4dannjjm 667 8 left leave VBN cord-023095-4dannjjm 667 9 atrium atrium NN cord-023095-4dannjjm 667 10 to to IN cord-023095-4dannjjm 667 11 aortic aortic JJ cord-023095-4dannjjm 667 12 root root NN cord-023095-4dannjjm 667 13 ratio ratio NN cord-023095-4dannjjm 667 14 ( ( -LRB- cord-023095-4dannjjm 667 15 LA LA NNP cord-023095-4dannjjm 667 16 / / SYM cord-023095-4dannjjm 667 17 Ao Ao NNP cord-023095-4dannjjm 667 18 ) ) -RRB- cord-023095-4dannjjm 667 19 41.5 41.5 CD cord-023095-4dannjjm 667 20 , , , cord-023095-4dannjjm 667 21 clinical clinical JJ cord-023095-4dannjjm 667 22 signs sign NNS cord-023095-4dannjjm 667 23 of of IN cord-023095-4dannjjm 667 24 HF HF NNP cord-023095-4dannjjm 667 25 and and CC cord-023095-4dannjjm 667 26 furosemide furosemide NN cord-023095-4dannjjm 667 27 responsiveness responsiveness NN cord-023095-4dannjjm 667 28 ) ) -RRB- cord-023095-4dannjjm 667 29 and and CC cord-023095-4dannjjm 667 30 5 5 LS cord-023095-4dannjjm 667 31 ) ) -RRB- cord-023095-4dannjjm 667 32 non non JJ cord-023095-4dannjjm 667 33 - - JJ cord-023095-4dannjjm 667 34 CKCS CKCS NNP cord-023095-4dannjjm 667 35 in in IN cord-023095-4dannjjm 667 36 HF HF NNP cord-023095-4dannjjm 667 37 . . . cord-023095-4dannjjm 668 1 Dogs Dogs NNP cord-023095-4dannjjm 668 2 in in IN cord-023095-4dannjjm 668 3 HF HF NNP cord-023095-4dannjjm 668 4 were be VBD cord-023095-4dannjjm 668 5 allowed allow VBN cord-023095-4dannjjm 668 6 HF HF NNP cord-023095-4dannjjm 668 7 therapy therapy NN cord-023095-4dannjjm 668 8 . . . cord-023095-4dannjjm 669 1 Both both DT cord-023095-4dannjjm 669 2 HR HR NNP cord-023095-4dannjjm 669 3 and and CC cord-023095-4dannjjm 669 4 HRV HRV NNP cord-023095-4dannjjm 669 5 were be VBD cord-023095-4dannjjm 669 6 analyzed analyze VBN cord-023095-4dannjjm 669 7 over over IN cord-023095-4dannjjm 669 8 a a DT cord-023095-4dannjjm 669 9 24-hour 24-hour JJ cord-023095-4dannjjm 669 10 period period NN cord-023095-4dannjjm 669 11 , , , cord-023095-4dannjjm 669 12 while while IN cord-023095-4dannjjm 669 13 HRV HRV NNP cord-023095-4dannjjm 669 14 were be VBD cord-023095-4dannjjm 669 15 also also RB cord-023095-4dannjjm 669 16 analysed analyse VBN cord-023095-4dannjjm 669 17 over over IN cord-023095-4dannjjm 669 18 a a DT cord-023095-4dannjjm 669 19 6-hour 6-hour CD cord-023095-4dannjjm 669 20 nightly nightly JJ cord-023095-4dannjjm 669 21 period period NN cord-023095-4dannjjm 669 22 . . . cord-023095-4dannjjm 670 1 Analyses analysis NNS cord-023095-4dannjjm 670 2 of of IN cord-023095-4dannjjm 670 3 variance variance NN cord-023095-4dannjjm 670 4 were be VBD cord-023095-4dannjjm 670 5 performed perform VBN cord-023095-4dannjjm 670 6 with with IN cord-023095-4dannjjm 670 7 HR HR NNP cord-023095-4dannjjm 670 8 or or CC cord-023095-4dannjjm 670 9 HRV HRV NNP cord-023095-4dannjjm 670 10 as as IN cord-023095-4dannjjm 670 11 response response NN cord-023095-4dannjjm 670 12 variables variable NNS cord-023095-4dannjjm 670 13 and and CC cord-023095-4dannjjm 670 14 the the DT cord-023095-4dannjjm 670 15 explanatory explanatory JJ cord-023095-4dannjjm 670 16 variables variable NNS cord-023095-4dannjjm 670 17 dog dog NN cord-023095-4dannjjm 670 18 group group NN cord-023095-4dannjjm 670 19 and and CC cord-023095-4dannjjm 670 20 echocardiographic echocardiographic JJ cord-023095-4dannjjm 670 21 indices index NNS cord-023095-4dannjjm 670 22 of of IN cord-023095-4dannjjm 670 23 MMVD MMVD NNP cord-023095-4dannjjm 670 24 were be VBD cord-023095-4dannjjm 670 25 included include VBN cord-023095-4dannjjm 670 26 separately separately RB cord-023095-4dannjjm 670 27 . . . cord-023095-4dannjjm 671 1 All all DT cord-023095-4dannjjm 671 2 P p NN cord-023095-4dannjjm 671 3 - - HYPH cord-023095-4dannjjm 671 4 values value NNS cord-023095-4dannjjm 671 5 were be VBD cord-023095-4dannjjm 671 6 Bonferroni Bonferroni NNP cord-023095-4dannjjm 671 7 corrected correct VBN cord-023095-4dannjjm 671 8 . . . cord-023095-4dannjjm 672 1 Minimum minimum NN cord-023095-4dannjjm 672 2 - - : cord-023095-4dannjjm 672 3 and and CC cord-023095-4dannjjm 672 4 mean mean VB cord-023095-4dannjjm 672 5 HR HR NNP cord-023095-4dannjjm 672 6 were be VBD cord-023095-4dannjjm 672 7 significantly significantly RB cord-023095-4dannjjm 672 8 higher high JJR cord-023095-4dannjjm 672 9 in in IN cord-023095-4dannjjm 672 10 CKCS CKCS NNP cord-023095-4dannjjm 672 11 with with IN cord-023095-4dannjjm 672 12 moderate moderate JJ cord-023095-4dannjjm 672 13 / / SYM cord-023095-4dannjjm 672 14 severe severe JJ cord-023095-4dannjjm 672 15 MR MR NNP cord-023095-4dannjjm 672 16 and and CC cord-023095-4dannjjm 672 17 in in IN cord-023095-4dannjjm 672 18 HF HF NNP cord-023095-4dannjjm 672 19 compared compare VBN cord-023095-4dannjjm 672 20 to to IN cord-023095-4dannjjm 672 21 CKCS CKCS NNP cord-023095-4dannjjm 672 22 with with IN cord-023095-4dannjjm 672 23 no/ no/ NNP cord-023095-4dannjjm 672 24 minimal minimal JJ cord-023095-4dannjjm 672 25 and and CC cord-023095-4dannjjm 672 26 mild mild JJ cord-023095-4dannjjm 672 27 MR MR NNP cord-023095-4dannjjm 672 28 ( ( -LRB- cord-023095-4dannjjm 672 29 all all DT cord-023095-4dannjjm 672 30 P p NN cord-023095-4dannjjm 672 31 o o NN cord-023095-4dannjjm 672 32 0.001 0.001 CD cord-023095-4dannjjm 672 33 ) ) -RRB- cord-023095-4dannjjm 672 34 . . . cord-023095-4dannjjm 673 1 Seven seven CD cord-023095-4dannjjm 673 2 out out IN cord-023095-4dannjjm 673 3 of of IN cord-023095-4dannjjm 673 4 26 26 CD cord-023095-4dannjjm 673 5 HRV HRV NNP cord-023095-4dannjjm 673 6 variables variable NNS cord-023095-4dannjjm 673 7 were be VBD cord-023095-4dannjjm 673 8 significantly significantly RB cord-023095-4dannjjm 673 9 decreased decrease VBN cord-023095-4dannjjm 673 10 in in IN cord-023095-4dannjjm 673 11 CKCS CKCS NNP cord-023095-4dannjjm 673 12 with with IN cord-023095-4dannjjm 673 13 moderate/ moderate/ CD cord-023095-4dannjjm 674 1 severe severe JJ cord-023095-4dannjjm 674 2 MR MR NNP cord-023095-4dannjjm 674 3 and and CC cord-023095-4dannjjm 674 4 in in IN cord-023095-4dannjjm 674 5 HF HF NNP cord-023095-4dannjjm 675 1 compared compare VBN cord-023095-4dannjjm 675 2 to to IN cord-023095-4dannjjm 675 3 CKCS CKCS NNP cord-023095-4dannjjm 675 4 with with IN cord-023095-4dannjjm 675 5 no no DT cord-023095-4dannjjm 675 6 / / SYM cord-023095-4dannjjm 675 7 minimal minimal JJ cord-023095-4dannjjm 675 8 and and CC cord-023095-4dannjjm 675 9 mild mild JJ cord-023095-4dannjjm 675 10 MR MR NNP cord-023095-4dannjjm 675 11 ( ( -LRB- cord-023095-4dannjjm 675 12 all all DT cord-023095-4dannjjm 675 13 P p NN cord-023095-4dannjjm 675 14 o o NN cord-023095-4dannjjm 675 15 0.02 0.02 CD cord-023095-4dannjjm 675 16 ) ) -RRB- cord-023095-4dannjjm 675 17 . . . cord-023095-4dannjjm 676 1 Another another DT cord-023095-4dannjjm 676 2 10 10 CD cord-023095-4dannjjm 676 3 HRV HRV NNP cord-023095-4dannjjm 676 4 variables variable NNS cord-023095-4dannjjm 676 5 showed show VBD cord-023095-4dannjjm 676 6 the the DT cord-023095-4dannjjm 676 7 same same JJ cord-023095-4dannjjm 676 8 groupwise groupwise NNP cord-023095-4dannjjm 676 9 differences difference NNS cord-023095-4dannjjm 676 10 ( ( -LRB- cord-023095-4dannjjm 676 11 all all DT cord-023095-4dannjjm 676 12 P p NN cord-023095-4dannjjm 676 13 o o NN cord-023095-4dannjjm 676 14 0.02 0.02 CD cord-023095-4dannjjm 676 15 ) ) -RRB- cord-023095-4dannjjm 676 16 , , , cord-023095-4dannjjm 676 17 except except IN cord-023095-4dannjjm 676 18 that that IN cord-023095-4dannjjm 676 19 the the DT cord-023095-4dannjjm 676 20 difference difference NN cord-023095-4dannjjm 676 21 between between IN cord-023095-4dannjjm 676 22 CKCS CKCS NNP cord-023095-4dannjjm 676 23 with with IN cord-023095-4dannjjm 676 24 mild mild JJ cord-023095-4dannjjm 676 25 MR MR NNP cord-023095-4dannjjm 676 26 and and CC cord-023095-4dannjjm 676 27 CKCS CKCS NNP cord-023095-4dannjjm 676 28 with with IN cord-023095-4dannjjm 676 29 moderate moderate JJ cord-023095-4dannjjm 676 30 / / SYM cord-023095-4dannjjm 676 31 severe severe JJ cord-023095-4dannjjm 676 32 MR MR NNP cord-023095-4dannjjm 676 33 did do VBD cord-023095-4dannjjm 676 34 not not RB cord-023095-4dannjjm 676 35 reach reach VB cord-023095-4dannjjm 676 36 statistical statistical JJ cord-023095-4dannjjm 676 37 significance significance NN cord-023095-4dannjjm 676 38 . . . cord-023095-4dannjjm 677 1 Mminimum Mminimum NNP cord-023095-4dannjjm 677 2 HR HR NNP cord-023095-4dannjjm 677 3 , , , cord-023095-4dannjjm 677 4 mean mean JJ cord-023095-4dannjjm 677 5 HR HR NNP cord-023095-4dannjjm 677 6 and and CC cord-023095-4dannjjm 677 7 the the DT cord-023095-4dannjjm 677 8 HRV HRV NNP cord-023095-4dannjjm 677 9 variables variable NNS cord-023095-4dannjjm 677 10 ( ( -LRB- cord-023095-4dannjjm 677 11 7 7 CD cord-023095-4dannjjm 677 12 and and CC cord-023095-4dannjjm 677 13 10 10 CD cord-023095-4dannjjm 677 14 ) ) -RRB- cord-023095-4dannjjm 677 15 differing differ VBG cord-023095-4dannjjm 677 16 between between IN cord-023095-4dannjjm 677 17 dog dog NN cord-023095-4dannjjm 677 18 groups group NNS cord-023095-4dannjjm 677 19 , , , cord-023095-4dannjjm 677 20 also also RB cord-023095-4dannjjm 677 21 consistently consistently RB cord-023095-4dannjjm 677 22 decreased decrease VBD cord-023095-4dannjjm 677 23 with with IN cord-023095-4dannjjm 677 24 increasing increase VBG cord-023095-4dannjjm 677 25 MR MR NNP cord-023095-4dannjjm 677 26 , , , cord-023095-4dannjjm 677 27 LA LA NNP cord-023095-4dannjjm 677 28 / / SYM cord-023095-4dannjjm 677 29 Ao Ao NNP cord-023095-4dannjjm 677 30 and and CC cord-023095-4dannjjm 677 31 the the DT cord-023095-4dannjjm 677 32 proximal proximal JJ cord-023095-4dannjjm 677 33 isovelocity isovelocity NN cord-023095-4dannjjm 677 34 surface surface NN cord-023095-4dannjjm 677 35 area area NN cord-023095-4dannjjm 677 36 in in IN cord-023095-4dannjjm 677 37 CKCS CKCS NNP cord-023095-4dannjjm 677 38 . . . cord-023095-4dannjjm 678 1 Non non JJ cord-023095-4dannjjm 678 2 - - NNP cord-023095-4dannjjm 678 3 CKCS CKCS NNP cord-023095-4dannjjm 678 4 in in IN cord-023095-4dannjjm 678 5 HF HF NNP cord-023095-4dannjjm 678 6 had have VBD cord-023095-4dannjjm 678 7 a a DT cord-023095-4dannjjm 678 8 lower low JJR cord-023095-4dannjjm 678 9 minimum minimum NN cord-023095-4dannjjm 678 10 HR hr NN cord-023095-4dannjjm 678 11 compared compare VBN cord-023095-4dannjjm 678 12 to to IN cord-023095-4dannjjm 678 13 CKCS CKCS NNP cord-023095-4dannjjm 678 14 in in IN cord-023095-4dannjjm 678 15 HF HF NNP cord-023095-4dannjjm 678 16 ( ( -LRB- cord-023095-4dannjjm 678 17 P p NN cord-023095-4dannjjm 678 18 5 5 CD cord-023095-4dannjjm 678 19 0.03 0.03 CD cord-023095-4dannjjm 678 20 ) ) -RRB- cord-023095-4dannjjm 678 21 and and CC cord-023095-4dannjjm 678 22 a a DT cord-023095-4dannjjm 678 23 higher high JJR cord-023095-4dannjjm 678 24 triangular triangular JJ cord-023095-4dannjjm 678 25 index index NN cord-023095-4dannjjm 678 26 measured measure VBN cord-023095-4dannjjm 678 27 in in IN cord-023095-4dannjjm 678 28 both both DT cord-023095-4dannjjm 678 29 periods period NNS cord-023095-4dannjjm 678 30 ( ( -LRB- cord-023095-4dannjjm 678 31 all all DT cord-023095-4dannjjm 678 32 P p NN cord-023095-4dannjjm 678 33 o o NN cord-023095-4dannjjm 678 34 0.04 0.04 CD cord-023095-4dannjjm 678 35 ) ) -RRB- cord-023095-4dannjjm 678 36 . . . cord-023095-4dannjjm 679 1 In in IN cord-023095-4dannjjm 679 2 conclusion conclusion NN cord-023095-4dannjjm 679 3 , , , cord-023095-4dannjjm 679 4 HR HR NNP cord-023095-4dannjjm 679 5 increased increase VBD cord-023095-4dannjjm 679 6 and and CC cord-023095-4dannjjm 679 7 most most JJS cord-023095-4dannjjm 679 8 HRV HRV NNP cord-023095-4dannjjm 679 9 variables variable NNS cord-023095-4dannjjm 679 10 decreased decrease VBD cord-023095-4dannjjm 679 11 with with IN cord-023095-4dannjjm 679 12 increasing increase VBG cord-023095-4dannjjm 679 13 severity severity NN cord-023095-4dannjjm 679 14 of of IN cord-023095-4dannjjm 679 15 MMVD MMVD NNP cord-023095-4dannjjm 679 16 in in IN cord-023095-4dannjjm 679 17 CKCS CKCS NNP cord-023095-4dannjjm 679 18 , , , cord-023095-4dannjjm 679 19 even even RB cord-023095-4dannjjm 679 20 prior prior RB cord-023095-4dannjjm 679 21 to to IN cord-023095-4dannjjm 679 22 the the DT cord-023095-4dannjjm 679 23 development development NN cord-023095-4dannjjm 679 24 of of IN cord-023095-4dannjjm 679 25 HF HF NNP cord-023095-4dannjjm 679 26 . . . cord-023095-4dannjjm 680 1 Other other JJ cord-023095-4dannjjm 680 2 breeds breed NNS cord-023095-4dannjjm 680 3 in in IN cord-023095-4dannjjm 680 4 HF HF NNP cord-023095-4dannjjm 680 5 secondary secondary JJ cord-023095-4dannjjm 680 6 to to IN cord-023095-4dannjjm 680 7 MMVD MMVD NNP cord-023095-4dannjjm 680 8 had have VBD cord-023095-4dannjjm 680 9 lower low JJR cord-023095-4dannjjm 680 10 minimum minimum NN cord-023095-4dannjjm 680 11 HR hr NN cord-023095-4dannjjm 680 12 , , , cord-023095-4dannjjm 680 13 but but CC cord-023095-4dannjjm 680 14 higher high JJR cord-023095-4dannjjm 680 15 triangular triangular JJ cord-023095-4dannjjm 680 16 index index NN cord-023095-4dannjjm 680 17 compared compare VBN cord-023095-4dannjjm 680 18 to to IN cord-023095-4dannjjm 680 19 CKCS CKCS NNP cord-023095-4dannjjm 680 20 in in IN cord-023095-4dannjjm 680 21 HF HF NNP cord-023095-4dannjjm 680 22 . . . cord-023095-4dannjjm 681 1 Although although IN cord-023095-4dannjjm 681 2 the the DT cord-023095-4dannjjm 681 3 cells cell NNS cord-023095-4dannjjm 681 4 in in IN cord-023095-4dannjjm 681 5 the the DT cord-023095-4dannjjm 681 6 specialized specialized JJ cord-023095-4dannjjm 681 7 conduction conduction NN cord-023095-4dannjjm 681 8 system system NN cord-023095-4dannjjm 681 9 in in IN cord-023095-4dannjjm 681 10 the the DT cord-023095-4dannjjm 681 11 heart heart NN cord-023095-4dannjjm 681 12 are be VBP cord-023095-4dannjjm 681 13 capable capable JJ cord-023095-4dannjjm 681 14 of of IN cord-023095-4dannjjm 681 15 initiating initiate VBG cord-023095-4dannjjm 681 16 their -PRON- PRP$ cord-023095-4dannjjm 681 17 own own JJ cord-023095-4dannjjm 681 18 impulse impulse NN cord-023095-4dannjjm 681 19 , , , cord-023095-4dannjjm 681 20 the the DT cord-023095-4dannjjm 681 21 rate rate NN cord-023095-4dannjjm 681 22 in in IN cord-023095-4dannjjm 681 23 which which WDT cord-023095-4dannjjm 681 24 those those DT cord-023095-4dannjjm 681 25 impulses impulse NNS cord-023095-4dannjjm 681 26 are be VBP cord-023095-4dannjjm 681 27 generated generate VBN cord-023095-4dannjjm 681 28 can can MD cord-023095-4dannjjm 681 29 be be VB cord-023095-4dannjjm 681 30 influenced influence VBN cord-023095-4dannjjm 681 31 by by IN cord-023095-4dannjjm 681 32 autonomic autonomic JJ cord-023095-4dannjjm 681 33 nervous nervous JJ cord-023095-4dannjjm 681 34 system system NN cord-023095-4dannjjm 681 35 . . . cord-023095-4dannjjm 682 1 Different different JJ cord-023095-4dannjjm 682 2 types type NNS cord-023095-4dannjjm 682 3 of of IN cord-023095-4dannjjm 682 4 respiratory respiratory JJ cord-023095-4dannjjm 682 5 patterns pattern NNS cord-023095-4dannjjm 682 6 can can MD cord-023095-4dannjjm 682 7 stimulate stimulate VB cord-023095-4dannjjm 682 8 autonomic autonomic JJ cord-023095-4dannjjm 682 9 nervous nervous JJ cord-023095-4dannjjm 682 10 system system NN cord-023095-4dannjjm 682 11 in in IN cord-023095-4dannjjm 682 12 different different JJ cord-023095-4dannjjm 682 13 manners manner NNS cord-023095-4dannjjm 682 14 . . . cord-023095-4dannjjm 683 1 Thus thus RB cord-023095-4dannjjm 683 2 , , , cord-023095-4dannjjm 683 3 non non JJ cord-023095-4dannjjm 683 4 - - JJ cord-023095-4dannjjm 683 5 sedated sedated JJ cord-023095-4dannjjm 683 6 rabbits rabbit NNS cord-023095-4dannjjm 683 7 were be VBD cord-023095-4dannjjm 683 8 studied study VBN cord-023095-4dannjjm 683 9 during during IN cord-023095-4dannjjm 683 10 forced force VBN cord-023095-4dannjjm 683 11 respiration respiration NN cord-023095-4dannjjm 683 12 aiming aim VBG cord-023095-4dannjjm 683 13 to to TO cord-023095-4dannjjm 683 14 evaluate evaluate VB cord-023095-4dannjjm 683 15 the the DT cord-023095-4dannjjm 683 16 influence influence NN cord-023095-4dannjjm 683 17 of of IN cord-023095-4dannjjm 683 18 this this DT cord-023095-4dannjjm 683 19 breathing breathing NN cord-023095-4dannjjm 683 20 pattern pattern NN cord-023095-4dannjjm 683 21 on on IN cord-023095-4dannjjm 683 22 heart heart NN cord-023095-4dannjjm 683 23 rate rate NN cord-023095-4dannjjm 683 24 . . . cord-023095-4dannjjm 684 1 Twenty twenty CD cord-023095-4dannjjm 684 2 male male NN cord-023095-4dannjjm 684 3 , , , cord-023095-4dannjjm 684 4 one one CD cord-023095-4dannjjm 684 5 - - HYPH cord-023095-4dannjjm 684 6 year year NN cord-023095-4dannjjm 684 7 - - HYPH cord-023095-4dannjjm 684 8 old old JJ cord-023095-4dannjjm 684 9 healthy healthy JJ cord-023095-4dannjjm 684 10 New New NNP cord-023095-4dannjjm 684 11 Zealand Zealand NNP cord-023095-4dannjjm 684 12 rabbits rabbit NNS cord-023095-4dannjjm 684 13 were be VBD cord-023095-4dannjjm 684 14 enrolled enrol VBN cord-023095-4dannjjm 684 15 in in IN cord-023095-4dannjjm 684 16 the the DT cord-023095-4dannjjm 684 17 study study NN cord-023095-4dannjjm 684 18 . . . cord-023095-4dannjjm 685 1 Animals animal NNS cord-023095-4dannjjm 685 2 were be VBD cord-023095-4dannjjm 685 3 set set VBN cord-023095-4dannjjm 685 4 in in IN cord-023095-4dannjjm 685 5 right right JJ cord-023095-4dannjjm 685 6 lateral lateral JJ cord-023095-4dannjjm 685 7 recumbency recumbency NN cord-023095-4dannjjm 685 8 and and CC cord-023095-4dannjjm 685 9 maintained maintain VBD cord-023095-4dannjjm 685 10 that that DT cord-023095-4dannjjm 685 11 way way NN cord-023095-4dannjjm 685 12 by by IN cord-023095-4dannjjm 685 13 physical physical JJ cord-023095-4dannjjm 685 14 contention contention NN cord-023095-4dannjjm 685 15 . . . cord-023095-4dannjjm 686 1 Chemical chemical JJ cord-023095-4dannjjm 686 2 sedation sedation NN cord-023095-4dannjjm 686 3 was be VBD cord-023095-4dannjjm 686 4 not not RB cord-023095-4dannjjm 686 5 used use VBN cord-023095-4dannjjm 686 6 . . . cord-023095-4dannjjm 687 1 Partial partial JJ cord-023095-4dannjjm 687 2 nasal nasal JJ cord-023095-4dannjjm 687 3 obstruction obstruction NN cord-023095-4dannjjm 687 4 by by IN cord-023095-4dannjjm 687 5 digital digital JJ cord-023095-4dannjjm 687 6 compression compression NN cord-023095-4dannjjm 687 7 was be VBD cord-023095-4dannjjm 687 8 applied apply VBN cord-023095-4dannjjm 687 9 to to IN cord-023095-4dannjjm 687 10 those those DT cord-023095-4dannjjm 687 11 rabbits rabbit NNS cord-023095-4dannjjm 687 12 for for IN cord-023095-4dannjjm 687 13 five five CD cord-023095-4dannjjm 687 14 seconds second NNS cord-023095-4dannjjm 687 15 , , , cord-023095-4dannjjm 687 16 eliciting elicit VBG cord-023095-4dannjjm 687 17 a a DT cord-023095-4dannjjm 687 18 forced force VBN cord-023095-4dannjjm 687 19 inhaling inhaling NN cord-023095-4dannjjm 687 20 and and CC cord-023095-4dannjjm 687 21 exhaling exhale VBG cord-023095-4dannjjm 687 22 against against IN cord-023095-4dannjjm 687 23 semi semi JJ cord-023095-4dannjjm 687 24 closed closed JJ cord-023095-4dannjjm 687 25 nostrils nostril NNS cord-023095-4dannjjm 687 26 . . . cord-023095-4dannjjm 688 1 Heart heart NN cord-023095-4dannjjm 688 2 rate rate NN cord-023095-4dannjjm 688 3 was be VBD cord-023095-4dannjjm 688 4 obtained obtain VBN cord-023095-4dannjjm 688 5 by by IN cord-023095-4dannjjm 688 6 measurement measurement NN cord-023095-4dannjjm 688 7 of of IN cord-023095-4dannjjm 688 8 two two CD cord-023095-4dannjjm 688 9 consecutives consecutive NNS cord-023095-4dannjjm 688 10 RR rr NN cord-023095-4dannjjm 688 11 intervals interval NNS cord-023095-4dannjjm 688 12 in in IN cord-023095-4dannjjm 688 13 the the DT cord-023095-4dannjjm 688 14 computerized computerized JJ cord-023095-4dannjjm 688 15 electrocardiography electrocardiography NN cord-023095-4dannjjm 688 16 , , , cord-023095-4dannjjm 688 17 recorded record VBN cord-023095-4dannjjm 688 18 continuously continuously RB cord-023095-4dannjjm 688 19 prior prior RB cord-023095-4dannjjm 688 20 and and CC cord-023095-4dannjjm 688 21 during during IN cord-023095-4dannjjm 688 22 the the DT cord-023095-4dannjjm 688 23 maneuver maneuver NN cord-023095-4dannjjm 688 24 . . . cord-023095-4dannjjm 689 1 Heart heart NN cord-023095-4dannjjm 689 2 rate rate NN cord-023095-4dannjjm 689 3 before before IN cord-023095-4dannjjm 689 4 the the DT cord-023095-4dannjjm 689 5 intervention intervention NN cord-023095-4dannjjm 689 6 was be VBD cord-023095-4dannjjm 689 7 251 251 CD cord-023095-4dannjjm 689 8 AE AE NNP cord-023095-4dannjjm 689 9 34 34 CD cord-023095-4dannjjm 689 10 bpm bpm NN cord-023095-4dannjjm 689 11 ( ( -LRB- cord-023095-4dannjjm 689 12 mean mean VB cord-023095-4dannjjm 689 13 AE AE NNP cord-023095-4dannjjm 689 14 standard standard JJ cord-023095-4dannjjm 689 15 deviation deviation NN cord-023095-4dannjjm 689 16 ) ) -RRB- cord-023095-4dannjjm 689 17 . . . cord-023095-4dannjjm 690 1 All all DT cord-023095-4dannjjm 690 2 rabbits rabbit NNS cord-023095-4dannjjm 690 3 submitted submit VBN cord-023095-4dannjjm 690 4 to to IN cord-023095-4dannjjm 690 5 the the DT cord-023095-4dannjjm 690 6 maneuver maneuver NN cord-023095-4dannjjm 690 7 showed show VBD cord-023095-4dannjjm 690 8 a a DT cord-023095-4dannjjm 690 9 dramatic dramatic JJ cord-023095-4dannjjm 690 10 reduction reduction NN cord-023095-4dannjjm 690 11 in in IN cord-023095-4dannjjm 690 12 this this DT cord-023095-4dannjjm 690 13 parameter parameter NN cord-023095-4dannjjm 690 14 . . . cord-023095-4dannjjm 691 1 After after IN cord-023095-4dannjjm 691 2 nasal nasal JJ cord-023095-4dannjjm 691 3 partial partial JJ cord-023095-4dannjjm 691 4 obstruction obstruction NN cord-023095-4dannjjm 691 5 , , , cord-023095-4dannjjm 691 6 heart heart NN cord-023095-4dannjjm 691 7 rate rate NN cord-023095-4dannjjm 691 8 was be VBD cord-023095-4dannjjm 691 9 142 142 CD cord-023095-4dannjjm 691 10 AE AE NNP cord-023095-4dannjjm 691 11 32 32 CD cord-023095-4dannjjm 691 12 bpm bpm NN cord-023095-4dannjjm 691 13 . . . cord-023095-4dannjjm 692 1 Data datum NNS cord-023095-4dannjjm 692 2 was be VBD cord-023095-4dannjjm 692 3 submitted submit VBN cord-023095-4dannjjm 692 4 to to IN cord-023095-4dannjjm 692 5 statistical statistical JJ cord-023095-4dannjjm 692 6 analysis analysis NN cord-023095-4dannjjm 692 7 by by IN cord-023095-4dannjjm 692 8 paired pair VBN cord-023095-4dannjjm 692 9 Student Student NNP cord-023095-4dannjjm 692 10 's 's POS cord-023095-4dannjjm 692 11 t t NN cord-023095-4dannjjm 692 12 test test NN cord-023095-4dannjjm 692 13 and and CC cord-023095-4dannjjm 692 14 a a DT cord-023095-4dannjjm 692 15 significant significant JJ cord-023095-4dannjjm 692 16 difference difference NN cord-023095-4dannjjm 692 17 between between IN cord-023095-4dannjjm 692 18 the the DT cord-023095-4dannjjm 692 19 heart heart NN cord-023095-4dannjjm 692 20 rate rate NN cord-023095-4dannjjm 692 21 before before RB cord-023095-4dannjjm 692 22 and and CC cord-023095-4dannjjm 692 23 after after IN cord-023095-4dannjjm 692 24 the the DT cord-023095-4dannjjm 692 25 maneuver maneuver NN cord-023095-4dannjjm 692 26 was be VBD cord-023095-4dannjjm 692 27 observed observe VBN cord-023095-4dannjjm 692 28 ( ( -LRB- cord-023095-4dannjjm 692 29 p p NN cord-023095-4dannjjm 692 30 o o CD cord-023095-4dannjjm 692 31 0.0001 0.0001 CD cord-023095-4dannjjm 692 32 ) ) -RRB- cord-023095-4dannjjm 692 33 . . . cord-023095-4dannjjm 693 1 Although although IN cord-023095-4dannjjm 693 2 the the DT cord-023095-4dannjjm 693 3 exactly exactly RB cord-023095-4dannjjm 693 4 mechanism mechanism NN cord-023095-4dannjjm 693 5 involved involve VBN cord-023095-4dannjjm 693 6 in in IN cord-023095-4dannjjm 693 7 this this DT cord-023095-4dannjjm 693 8 response response NN cord-023095-4dannjjm 693 9 was be VBD cord-023095-4dannjjm 693 10 not not RB cord-023095-4dannjjm 693 11 elucidated elucidate VBN cord-023095-4dannjjm 693 12 , , , cord-023095-4dannjjm 693 13 the the DT cord-023095-4dannjjm 693 14 presented present VBN cord-023095-4dannjjm 693 15 data datum NNS cord-023095-4dannjjm 693 16 support support VBP cord-023095-4dannjjm 693 17 the the DT cord-023095-4dannjjm 693 18 applicability applicability NN cord-023095-4dannjjm 693 19 of of IN cord-023095-4dannjjm 693 20 this this DT cord-023095-4dannjjm 693 21 maneuver maneuver NN cord-023095-4dannjjm 693 22 as as IN cord-023095-4dannjjm 693 23 an an DT cord-023095-4dannjjm 693 24 efficient efficient JJ cord-023095-4dannjjm 693 25 method method NN cord-023095-4dannjjm 693 26 for for IN cord-023095-4dannjjm 693 27 non non JJ cord-023095-4dannjjm 693 28 - - JJ cord-023095-4dannjjm 693 29 pharmacological pharmacological JJ cord-023095-4dannjjm 693 30 heart heart NN cord-023095-4dannjjm 693 31 rate rate NN cord-023095-4dannjjm 693 32 reduction reduction NN cord-023095-4dannjjm 693 33 in in IN cord-023095-4dannjjm 693 34 rabbits rabbit NNS cord-023095-4dannjjm 693 35 . . . cord-023095-4dannjjm 694 1 Obesity obesity NN cord-023095-4dannjjm 694 2 can can MD cord-023095-4dannjjm 694 3 affect affect VB cord-023095-4dannjjm 694 4 cardiac cardiac JJ cord-023095-4dannjjm 694 5 function function NN cord-023095-4dannjjm 694 6 due due IN cord-023095-4dannjjm 694 7 to to IN cord-023095-4dannjjm 694 8 effects effect NNS cord-023095-4dannjjm 694 9 on on IN cord-023095-4dannjjm 694 10 cardiac cardiac JJ cord-023095-4dannjjm 694 11 rhythm rhythm NN cord-023095-4dannjjm 694 12 , , , cord-023095-4dannjjm 694 13 ventricular ventricular JJ cord-023095-4dannjjm 694 14 volume volume NN cord-023095-4dannjjm 694 15 and and CC cord-023095-4dannjjm 694 16 blood blood NN cord-023095-4dannjjm 694 17 pressure pressure NN cord-023095-4dannjjm 694 18 . . . cord-023095-4dannjjm 695 1 The the DT cord-023095-4dannjjm 695 2 purpose purpose NN cord-023095-4dannjjm 695 3 of of IN cord-023095-4dannjjm 695 4 this this DT cord-023095-4dannjjm 695 5 study study NN cord-023095-4dannjjm 695 6 was be VBD cord-023095-4dannjjm 695 7 to to TO cord-023095-4dannjjm 695 8 determine determine VB cord-023095-4dannjjm 695 9 the the DT cord-023095-4dannjjm 695 10 effects effect NNS cord-023095-4dannjjm 695 11 of of IN cord-023095-4dannjjm 695 12 obesity obesity NN cord-023095-4dannjjm 695 13 and and CC cord-023095-4dannjjm 695 14 overweight overweight NN cord-023095-4dannjjm 695 15 on on IN cord-023095-4dannjjm 695 16 noninvasive noninvasive JJ cord-023095-4dannjjm 695 17 systemic systemic JJ cord-023095-4dannjjm 695 18 blood blood NN cord-023095-4dannjjm 695 19 pressure pressure NN cord-023095-4dannjjm 695 20 and and CC cord-023095-4dannjjm 695 21 Doppler Doppler NNP cord-023095-4dannjjm 695 22 echocardiographic echocardiographic JJ cord-023095-4dannjjm 695 23 parameters parameter NNS cord-023095-4dannjjm 695 24 in in IN cord-023095-4dannjjm 695 25 cats cat NNS cord-023095-4dannjjm 695 26 without without IN cord-023095-4dannjjm 695 27 others other NNS cord-023095-4dannjjm 695 28 causes cause VBZ cord-023095-4dannjjm 695 29 of of IN cord-023095-4dannjjm 695 30 cardiac cardiac JJ cord-023095-4dannjjm 695 31 hypertrophy hypertrophy NN cord-023095-4dannjjm 695 32 . . . cord-023095-4dannjjm 696 1 The the DT cord-023095-4dannjjm 696 2 study study NN cord-023095-4dannjjm 696 3 groups group NNS cord-023095-4dannjjm 696 4 comprised comprise VBD cord-023095-4dannjjm 696 5 fifteen fifteen CD cord-023095-4dannjjm 696 6 obese obese JJ cord-023095-4dannjjm 696 7 cats cat NNS cord-023095-4dannjjm 696 8 with with IN cord-023095-4dannjjm 696 9 mean mean JJ cord-023095-4dannjjm 696 10 body body NN cord-023095-4dannjjm 696 11 score score NN cord-023095-4dannjjm 696 12 index index NN cord-023095-4dannjjm 696 13 ( ( -LRB- cord-023095-4dannjjm 696 14 BSI BSI NNP cord-023095-4dannjjm 696 15 ) ) -RRB- cord-023095-4dannjjm 696 16 of of IN cord-023095-4dannjjm 696 17 8,8 8,8 CD cord-023095-4dannjjm 696 18 , , , cord-023095-4dannjjm 696 19 seven seven CD cord-023095-4dannjjm 696 20 overweight overweight JJ cord-023095-4dannjjm 696 21 cats cat NNS cord-023095-4dannjjm 696 22 ( ( -LRB- cord-023095-4dannjjm 696 23 BSI BSI NNP cord-023095-4dannjjm 696 24 5 5 CD cord-023095-4dannjjm 696 25 6,3 6,3 CD cord-023095-4dannjjm 696 26 ) ) -RRB- cord-023095-4dannjjm 696 27 and and CC cord-023095-4dannjjm 696 28 seven seven CD cord-023095-4dannjjm 696 29 cats cat NNS cord-023095-4dannjjm 696 30 with with IN cord-023095-4dannjjm 696 31 ideal ideal JJ cord-023095-4dannjjm 696 32 BSI BSI NNP cord-023095-4dannjjm 696 33 ( ( -LRB- cord-023095-4dannjjm 696 34 4,9 4,9 CD cord-023095-4dannjjm 696 35 ) ) -RRB- cord-023095-4dannjjm 696 36 . . . cord-023095-4dannjjm 697 1 The the DT cord-023095-4dannjjm 697 2 blood blood NN cord-023095-4dannjjm 697 3 pressure pressure NN cord-023095-4dannjjm 697 4 was be VBD cord-023095-4dannjjm 697 5 measured measure VBN cord-023095-4dannjjm 697 6 by by IN cord-023095-4dannjjm 697 7 Doppler Doppler NNP cord-023095-4dannjjm 697 8 method method NN cord-023095-4dannjjm 697 9 and and CC cord-023095-4dannjjm 697 10 the the DT cord-023095-4dannjjm 697 11 Doppler Doppler NNP cord-023095-4dannjjm 697 12 echocardiography echocardiography NN cord-023095-4dannjjm 697 13 was be VBD cord-023095-4dannjjm 697 14 performed perform VBN cord-023095-4dannjjm 697 15 in in IN cord-023095-4dannjjm 697 16 conscious conscious JJ cord-023095-4dannjjm 697 17 animals animal NNS cord-023095-4dannjjm 697 18 . . . cord-023095-4dannjjm 698 1 The the DT cord-023095-4dannjjm 698 2 statistical statistical JJ cord-023095-4dannjjm 698 3 analysis analysis NN cord-023095-4dannjjm 698 4 was be VBD cord-023095-4dannjjm 698 5 performed perform VBN cord-023095-4dannjjm 698 6 by by IN cord-023095-4dannjjm 698 7 analysis analysis NN cord-023095-4dannjjm 698 8 of of IN cord-023095-4dannjjm 698 9 variance variance NN cord-023095-4dannjjm 698 10 followed follow VBN cord-023095-4dannjjm 698 11 by by IN cord-023095-4dannjjm 698 12 Tukey Tukey NNP cord-023095-4dannjjm 698 13 's 's POS cord-023095-4dannjjm 698 14 test test NN cord-023095-4dannjjm 698 15 and and CC cord-023095-4dannjjm 698 16 Pearson Pearson NNP cord-023095-4dannjjm 698 17 's 's POS cord-023095-4dannjjm 698 18 correlation correlation NN cord-023095-4dannjjm 698 19 . . . cord-023095-4dannjjm 699 1 The the DT cord-023095-4dannjjm 699 2 blood blood NN cord-023095-4dannjjm 699 3 pressure pressure NN cord-023095-4dannjjm 699 4 values value NNS cord-023095-4dannjjm 699 5 of of IN cord-023095-4dannjjm 699 6 the the DT cord-023095-4dannjjm 699 7 obese obese JJ cord-023095-4dannjjm 699 8 cats cat NNS cord-023095-4dannjjm 699 9 were be VBD cord-023095-4dannjjm 699 10 superior superior JJ cord-023095-4dannjjm 699 11 ( ( -LRB- cord-023095-4dannjjm 699 12 159,12 159,12 NNP cord-023095-4dannjjm 699 13 AE AE NNP cord-023095-4dannjjm 699 14 11,22 11,22 CD cord-023095-4dannjjm 699 15 mmHg mmHg NNS cord-023095-4dannjjm 699 16 , , , cord-023095-4dannjjm 699 17 p p NN cord-023095-4dannjjm 699 18 o o NN cord-023095-4dannjjm 699 19 0,0001 0,0001 CD cord-023095-4dannjjm 699 20 ) ) -RRB- cord-023095-4dannjjm 699 21 than than IN cord-023095-4dannjjm 699 22 in in IN cord-023095-4dannjjm 699 23 overweight overweight NN cord-023095-4dannjjm 699 24 ( ( -LRB- cord-023095-4dannjjm 699 25 134,45 134,45 CD cord-023095-4dannjjm 699 26 AE AE NNP cord-023095-4dannjjm 699 27 13,81 13,81 CD cord-023095-4dannjjm 699 28 mmHg mmHg NNS cord-023095-4dannjjm 699 29 ) ) -RRB- cord-023095-4dannjjm 699 30 and and CC cord-023095-4dannjjm 699 31 normal normal JJ cord-023095-4dannjjm 699 32 cats cat NNS cord-023095-4dannjjm 700 1 ( ( -LRB- cord-023095-4dannjjm 700 2 136,90 136,90 CD cord-023095-4dannjjm 700 3 AE AE NNP cord-023095-4dannjjm 700 4 13,17 13,17 CD cord-023095-4dannjjm 700 5 mmHg mmHg NNS cord-023095-4dannjjm 700 6 ) ) -RRB- cord-023095-4dannjjm 700 7 and and CC cord-023095-4dannjjm 701 1 57 57 CD cord-023095-4dannjjm 701 2 % % NN cord-023095-4dannjjm 701 3 of of IN cord-023095-4dannjjm 701 4 the the DT cord-023095-4dannjjm 701 5 obese obese JJ cord-023095-4dannjjm 701 6 cats cat NNS cord-023095-4dannjjm 701 7 had have VBD cord-023095-4dannjjm 701 8 blood blood NN cord-023095-4dannjjm 701 9 pressure pressure NN cord-023095-4dannjjm 701 10 higher high JJR cord-023095-4dannjjm 701 11 than than IN cord-023095-4dannjjm 701 12 160 160 CD cord-023095-4dannjjm 701 13 mmHg mmHg NNS cord-023095-4dannjjm 701 14 . . . cord-023095-4dannjjm 702 1 There there EX cord-023095-4dannjjm 702 2 were be VBD cord-023095-4dannjjm 702 3 observed observe VBN cord-023095-4dannjjm 702 4 differences difference NNS cord-023095-4dannjjm 702 5 on on IN cord-023095-4dannjjm 702 6 the the DT cord-023095-4dannjjm 702 7 ratio ratio NN cord-023095-4dannjjm 702 8 of of IN cord-023095-4dannjjm 702 9 early early JJ cord-023095-4dannjjm 702 10 ( ( -LRB- cord-023095-4dannjjm 702 11 E e NN cord-023095-4dannjjm 702 12 ) ) -RRB- cord-023095-4dannjjm 702 13 and and CC cord-023095-4dannjjm 702 14 late late JJ cord-023095-4dannjjm 702 15 ( ( -LRB- cord-023095-4dannjjm 702 16 A a NN cord-023095-4dannjjm 702 17 ) ) -RRB- cord-023095-4dannjjm 702 18 left leave VBN cord-023095-4dannjjm 702 19 ventricular ventricular JJ cord-023095-4dannjjm 702 20 filling filling NN cord-023095-4dannjjm 702 21 velocity velocity NN cord-023095-4dannjjm 702 22 ( ( -LRB- cord-023095-4dannjjm 702 23 p p NN cord-023095-4dannjjm 702 24 5 5 CD cord-023095-4dannjjm 702 25 0,008 0,008 CD cord-023095-4dannjjm 702 26 ) ) -RRB- cord-023095-4dannjjm 702 27 of of IN cord-023095-4dannjjm 702 28 obese obese JJ cord-023095-4dannjjm 702 29 animals animal NNS cord-023095-4dannjjm 703 1 ( ( -LRB- cord-023095-4dannjjm 703 2 E E NNP cord-023095-4dannjjm 703 3 / / SYM cord-023095-4dannjjm 703 4 A a NN cord-023095-4dannjjm 703 5 5 5 CD cord-023095-4dannjjm 703 6 1,07 1,07 CD cord-023095-4dannjjm 703 7 AE AE NNP cord-023095-4dannjjm 703 8 0,39 0,39 NNP cord-023095-4dannjjm 703 9 ) ) -RRB- cord-023095-4dannjjm 704 1 compared compare VBN cord-023095-4dannjjm 704 2 to to IN cord-023095-4dannjjm 704 3 overweight overweight NN cord-023095-4dannjjm 704 4 ( ( -LRB- cord-023095-4dannjjm 704 5 1,68 1,68 CD cord-023095-4dannjjm 704 6 AE AE NNP cord-023095-4dannjjm 704 7 0,37 0,37 NNP cord-023095-4dannjjm 704 8 ) ) -RRB- cord-023095-4dannjjm 704 9 and and CC cord-023095-4dannjjm 704 10 normal normal JJ cord-023095-4dannjjm 704 11 cats cat NNS cord-023095-4dannjjm 704 12 ( ( -LRB- cord-023095-4dannjjm 704 13 1,43 1,43 CD cord-023095-4dannjjm 704 14 AE AE NNP cord-023095-4dannjjm 704 15 0,24 0,24 NN cord-023095-4dannjjm 704 16 ) ) -RRB- cord-023095-4dannjjm 704 17 . . . cord-023095-4dannjjm 705 1 Seven seven CD cord-023095-4dannjjm 705 2 obese obese JJ cord-023095-4dannjjm 705 3 cats cat NNS cord-023095-4dannjjm 705 4 ( ( -LRB- cord-023095-4dannjjm 705 5 50 50 CD cord-023095-4dannjjm 705 6 % % NN cord-023095-4dannjjm 705 7 ) ) -RRB- cord-023095-4dannjjm 705 8 had have VBD cord-023095-4dannjjm 705 9 inversion inversion NN cord-023095-4dannjjm 705 10 of of IN cord-023095-4dannjjm 705 11 E e NN cord-023095-4dannjjm 705 12 / / CC cord-023095-4dannjjm 705 13 A a NN cord-023095-4dannjjm 705 14 compatible compatible JJ cord-023095-4dannjjm 705 15 with with IN cord-023095-4dannjjm 705 16 diastolic diastolic JJ cord-023095-4dannjjm 705 17 dysfunction dysfunction NN cord-023095-4dannjjm 705 18 and and CC cord-023095-4dannjjm 705 19 there there EX cord-023095-4dannjjm 705 20 were be VBD cord-023095-4dannjjm 705 21 negative negative JJ cord-023095-4dannjjm 705 22 correlation correlation NN cord-023095-4dannjjm 705 23 ( ( -LRB- cord-023095-4dannjjm 706 1 r r LS cord-023095-4dannjjm 706 2 5 5 CD cord-023095-4dannjjm 706 3 À0,453 à0,453 CD cord-023095-4dannjjm 706 4 , , , cord-023095-4dannjjm 706 5 p p NN cord-023095-4dannjjm 706 6 5 5 CD cord-023095-4dannjjm 706 7 0,026 0,026 CD cord-023095-4dannjjm 706 8 ) ) -RRB- cord-023095-4dannjjm 706 9 between between IN cord-023095-4dannjjm 706 10 the the DT cord-023095-4dannjjm 706 11 E e NN cord-023095-4dannjjm 706 12 / / SYM cord-023095-4dannjjm 706 13 A a DT cord-023095-4dannjjm 706 14 ratio ratio NN cord-023095-4dannjjm 706 15 and and CC cord-023095-4dannjjm 706 16 blood blood NN cord-023095-4dannjjm 706 17 pressure pressure NN cord-023095-4dannjjm 706 18 values value NNS cord-023095-4dannjjm 706 19 . . . cord-023095-4dannjjm 707 1 Other other JJ cord-023095-4dannjjm 707 2 differences difference NNS cord-023095-4dannjjm 707 3 observed observe VBD cord-023095-4dannjjm 707 4 were be VBD cord-023095-4dannjjm 707 5 increases increase NNS cord-023095-4dannjjm 707 6 in in IN cord-023095-4dannjjm 707 7 left left JJ cord-023095-4dannjjm 707 8 ventricular ventricular JJ cord-023095-4dannjjm 707 9 septum septum NN cord-023095-4dannjjm 707 10 in in IN cord-023095-4dannjjm 707 11 diastole diastole NN cord-023095-4dannjjm 707 12 ( ( -LRB- cord-023095-4dannjjm 707 13 p p NN cord-023095-4dannjjm 707 14 5 5 CD cord-023095-4dannjjm 707 15 0,002 0,002 CD cord-023095-4dannjjm 707 16 ) ) -RRB- cord-023095-4dannjjm 707 17 and and CC cord-023095-4dannjjm 707 18 in in IN cord-023095-4dannjjm 707 19 free free JJ cord-023095-4dannjjm 707 20 wall wall NN cord-023095-4dannjjm 707 21 in in IN cord-023095-4dannjjm 707 22 diastole diastole NN cord-023095-4dannjjm 707 23 ( ( -LRB- cord-023095-4dannjjm 707 24 p p NN cord-023095-4dannjjm 707 25 5 5 CD cord-023095-4dannjjm 707 26 0,023 0,023 CD cord-023095-4dannjjm 707 27 ) ) -RRB- cord-023095-4dannjjm 707 28 and and CC cord-023095-4dannjjm 707 29 systole systole NN cord-023095-4dannjjm 707 30 ( ( -LRB- cord-023095-4dannjjm 707 31 p p NN cord-023095-4dannjjm 707 32 5 5 CD cord-023095-4dannjjm 707 33 0,042 0,042 CD cord-023095-4dannjjm 707 34 ) ) -RRB- cord-023095-4dannjjm 707 35 of of IN cord-023095-4dannjjm 707 36 the the DT cord-023095-4dannjjm 707 37 obese obese JJ cord-023095-4dannjjm 707 38 animals animal NNS cord-023095-4dannjjm 707 39 compared compare VBN cord-023095-4dannjjm 707 40 to to IN cord-023095-4dannjjm 707 41 overweight overweight JJ cord-023095-4dannjjm 707 42 and and CC cord-023095-4dannjjm 707 43 normal normal JJ cord-023095-4dannjjm 707 44 cats cat NNS cord-023095-4dannjjm 707 45 . . . cord-023095-4dannjjm 708 1 These these DT cord-023095-4dannjjm 708 2 results result NNS cord-023095-4dannjjm 708 3 demonstrate demonstrate VBP cord-023095-4dannjjm 708 4 the the DT cord-023095-4dannjjm 708 5 possibility possibility NN cord-023095-4dannjjm 708 6 of of IN cord-023095-4dannjjm 708 7 cardiovascular cardiovascular JJ cord-023095-4dannjjm 708 8 effects effect NNS cord-023095-4dannjjm 708 9 related relate VBN cord-023095-4dannjjm 708 10 to to IN cord-023095-4dannjjm 708 11 obesity obesity NN cord-023095-4dannjjm 708 12 in in IN cord-023095-4dannjjm 708 13 cats cat NNS cord-023095-4dannjjm 708 14 , , , cord-023095-4dannjjm 708 15 such such JJ cord-023095-4dannjjm 708 16 as as IN cord-023095-4dannjjm 708 17 systemic systemic JJ cord-023095-4dannjjm 708 18 arterial arterial JJ cord-023095-4dannjjm 708 19 hypertension hypertension NN cord-023095-4dannjjm 708 20 and and CC cord-023095-4dannjjm 708 21 secondary secondary JJ cord-023095-4dannjjm 708 22 diastolic diastolic JJ cord-023095-4dannjjm 708 23 dysfunction dysfunction NN cord-023095-4dannjjm 708 24 . . . cord-023095-4dannjjm 709 1 Diuretic diuretic JJ cord-023095-4dannjjm 709 2 therapy therapy NN cord-023095-4dannjjm 709 3 reduces reduce VBZ cord-023095-4dannjjm 709 4 preload preload NN cord-023095-4dannjjm 709 5 , , , cord-023095-4dannjjm 709 6 and and CC cord-023095-4dannjjm 709 7 relieves relieve VBZ cord-023095-4dannjjm 709 8 congestion congestion NN cord-023095-4dannjjm 709 9 secondary secondary JJ cord-023095-4dannjjm 709 10 to to IN cord-023095-4dannjjm 709 11 cardiac cardiac JJ cord-023095-4dannjjm 709 12 dysfunction dysfunction NN cord-023095-4dannjjm 709 13 . . . cord-023095-4dannjjm 710 1 Torsemide Torsemide NNP cord-023095-4dannjjm 710 2 ( ( -LRB- cord-023095-4dannjjm 710 3 torasemide torasemide NNP cord-023095-4dannjjm 710 4 ) ) -RRB- cord-023095-4dannjjm 710 5 is be VBZ cord-023095-4dannjjm 710 6 a a DT cord-023095-4dannjjm 710 7 loop loop NN cord-023095-4dannjjm 710 8 diuretic diuretic NN cord-023095-4dannjjm 710 9 with with IN cord-023095-4dannjjm 710 10 longer long JJR cord-023095-4dannjjm 710 11 duration duration NN cord-023095-4dannjjm 710 12 of of IN cord-023095-4dannjjm 710 13 action action NN cord-023095-4dannjjm 710 14 , , , cord-023095-4dannjjm 710 15 less less RBR cord-023095-4dannjjm 710 16 diuretic diuretic JJ cord-023095-4dannjjm 710 17 resistance resistance NN cord-023095-4dannjjm 710 18 , , , cord-023095-4dannjjm 710 19 and and CC cord-023095-4dannjjm 710 20 adjunctive adjunctive JJ cord-023095-4dannjjm 710 21 aldosterone aldosterone NN cord-023095-4dannjjm 710 22 antagonism antagonism NN cord-023095-4dannjjm 710 23 as as IN cord-023095-4dannjjm 710 24 compared compare VBN cord-023095-4dannjjm 710 25 to to IN cord-023095-4dannjjm 710 26 furosemide furosemide NN cord-023095-4dannjjm 710 27 . . . cord-023095-4dannjjm 711 1 We -PRON- PRP cord-023095-4dannjjm 711 2 hypothesized hypothesize VBD cord-023095-4dannjjm 711 3 that that IN cord-023095-4dannjjm 711 4 torsemide torsemide NN cord-023095-4dannjjm 711 5 was be VBD cord-023095-4dannjjm 711 6 no no DT cord-023095-4dannjjm 711 7 less less RBR cord-023095-4dannjjm 711 8 effective effective JJ cord-023095-4dannjjm 711 9 than than IN cord-023095-4dannjjm 711 10 furosemide furosemide NN cord-023095-4dannjjm 711 11 at at IN cord-023095-4dannjjm 711 12 diuresis diuresis NN cord-023095-4dannjjm 711 13 , , , cord-023095-4dannjjm 711 14 control control NN cord-023095-4dannjjm 711 15 of of IN cord-023095-4dannjjm 711 16 clinical clinical JJ cord-023095-4dannjjm 711 17 signs sign NNS cord-023095-4dannjjm 711 18 , , , cord-023095-4dannjjm 711 19 and and CC cord-023095-4dannjjm 711 20 maintenance maintenance NN cord-023095-4dannjjm 711 21 of of IN cord-023095-4dannjjm 711 22 quality quality NN cord-023095-4dannjjm 711 23 of of IN cord-023095-4dannjjm 711 24 life life NN cord-023095-4dannjjm 711 25 in in IN cord-023095-4dannjjm 711 26 dogs dog NNS cord-023095-4dannjjm 711 27 with with IN cord-023095-4dannjjm 711 28 congestive congestive JJ cord-023095-4dannjjm 711 29 heart heart NN cord-023095-4dannjjm 711 30 failure failure NN cord-023095-4dannjjm 711 31 . . . cord-023095-4dannjjm 712 1 A a DT cord-023095-4dannjjm 712 2 double double RB cord-023095-4dannjjm 712 3 - - HYPH cord-023095-4dannjjm 712 4 blinded blinded JJ cord-023095-4dannjjm 712 5 , , , cord-023095-4dannjjm 712 6 randomized randomized JJ cord-023095-4dannjjm 712 7 , , , cord-023095-4dannjjm 712 8 crossover crossover JJ cord-023095-4dannjjm 712 9 clinical clinical JJ cord-023095-4dannjjm 712 10 trial trial NN cord-023095-4dannjjm 712 11 was be VBD cord-023095-4dannjjm 712 12 performed perform VBN cord-023095-4dannjjm 712 13 in in IN cord-023095-4dannjjm 712 14 7 7 CD cord-023095-4dannjjm 712 15 dogs dog NNS cord-023095-4dannjjm 712 16 with with IN cord-023095-4dannjjm 712 17 stable stable JJ cord-023095-4dannjjm 712 18 heart heart NN cord-023095-4dannjjm 712 19 failure failure NN cord-023095-4dannjjm 712 20 receiving receive VBG cord-023095-4dannjjm 712 21 BID BID VBN cord-023095-4dannjjm 712 22 furosemide furosemide NN cord-023095-4dannjjm 712 23 and and CC cord-023095-4dannjjm 712 24 adjunctive adjunctive JJ cord-023095-4dannjjm 712 25 medications medication NNS cord-023095-4dannjjm 712 26 . . . cord-023095-4dannjjm 713 1 Dogs dog NNS cord-023095-4dannjjm 713 2 were be VBD cord-023095-4dannjjm 713 3 randomized randomize VBN cord-023095-4dannjjm 713 4 to to IN cord-023095-4dannjjm 713 5 their -PRON- PRP$ cord-023095-4dannjjm 713 6 current current JJ cord-023095-4dannjjm 713 7 furosemide furosemide NN cord-023095-4dannjjm 713 8 dose dose NN cord-023095-4dannjjm 713 9 or or CC cord-023095-4dannjjm 713 10 torsemide torsemide NN cord-023095-4dannjjm 713 11 ( ( -LRB- cord-023095-4dannjjm 713 12 calculated calculate VBN cord-023095-4dannjjm 713 13 as as IN cord-023095-4dannjjm 713 14 1/10 1/10 CD cord-023095-4dannjjm 713 15 of of IN cord-023095-4dannjjm 713 16 the the DT cord-023095-4dannjjm 713 17 daily daily JJ cord-023095-4dannjjm 713 18 furosemide furosemide NN cord-023095-4dannjjm 713 19 dose dose NN cord-023095-4dannjjm 713 20 divided divide VBN cord-023095-4dannjjm 713 21 into into IN cord-023095-4dannjjm 713 22 BID BID NNP cord-023095-4dannjjm 713 23 dosing dosing NN cord-023095-4dannjjm 713 24 ) ) -RRB- cord-023095-4dannjjm 713 25 . . . cord-023095-4dannjjm 714 1 Crossover crossover NN cord-023095-4dannjjm 714 2 occurred occur VBD cord-023095-4dannjjm 714 3 at at IN cord-023095-4dannjjm 714 4 day day NN cord-023095-4dannjjm 714 5 7 7 CD cord-023095-4dannjjm 714 6 and and CC cord-023095-4dannjjm 714 7 the the DT cord-023095-4dannjjm 714 8 study study NN cord-023095-4dannjjm 714 9 ended end VBD cord-023095-4dannjjm 714 10 on on IN cord-023095-4dannjjm 714 11 day day NN cord-023095-4dannjjm 714 12 14 14 CD cord-023095-4dannjjm 714 13 . . . cord-023095-4dannjjm 715 1 Clinical clinical JJ cord-023095-4dannjjm 715 2 , , , cord-023095-4dannjjm 715 3 laboratory laboratory NN cord-023095-4dannjjm 715 4 , , , cord-023095-4dannjjm 715 5 radiographic radiographic JJ cord-023095-4dannjjm 715 6 , , , cord-023095-4dannjjm 715 7 and and CC cord-023095-4dannjjm 715 8 owner owner NN cord-023095-4dannjjm 715 9 - - HYPH cord-023095-4dannjjm 715 10 perceived perceive VBN cord-023095-4dannjjm 715 11 quality quality NN cord-023095-4dannjjm 715 12 of of IN cord-023095-4dannjjm 715 13 life life NN cord-023095-4dannjjm 715 14 variables variable NNS cord-023095-4dannjjm 715 15 were be VBD cord-023095-4dannjjm 715 16 evaluated evaluate VBN cord-023095-4dannjjm 715 17 on on IN cord-023095-4dannjjm 715 18 days day NNS cord-023095-4dannjjm 715 19 0 0 CD cord-023095-4dannjjm 715 20 , , , cord-023095-4dannjjm 715 21 7 7 CD cord-023095-4dannjjm 715 22 and and CC cord-023095-4dannjjm 715 23 14 14 CD cord-023095-4dannjjm 715 24 . . . cord-023095-4dannjjm 716 1 No no DT cord-023095-4dannjjm 716 2 dog dog NN cord-023095-4dannjjm 716 3 developed develop VBD cord-023095-4dannjjm 716 4 recurrent recurrent JJ cord-023095-4dannjjm 716 5 heart heart NN cord-023095-4dannjjm 716 6 failure failure NN cord-023095-4dannjjm 716 7 during during IN cord-023095-4dannjjm 716 8 the the DT cord-023095-4dannjjm 716 9 study study NN cord-023095-4dannjjm 716 10 . . . cord-023095-4dannjjm 717 1 Average average JJ cord-023095-4dannjjm 717 2 furosemide furosemide NN cord-023095-4dannjjm 717 3 dose dose NN cord-023095-4dannjjm 717 4 on on IN cord-023095-4dannjjm 717 5 day day NN cord-023095-4dannjjm 717 6 0 0 CD cord-023095-4dannjjm 717 7 was be VBD cord-023095-4dannjjm 717 8 5.13 5.13 CD cord-023095-4dannjjm 717 9 mg mg NNP cord-023095-4dannjjm 717 10 / / SYM cord-023095-4dannjjm 717 11 kg kg NNP cord-023095-4dannjjm 717 12 / / SYM cord-023095-4dannjjm 717 13 day day NN cord-023095-4dannjjm 717 14 ( ( -LRB- cord-023095-4dannjjm 717 15 range range NN cord-023095-4dannjjm 717 16 , , , cord-023095-4dannjjm 717 17 2.8 2.8 CD cord-023095-4dannjjm 717 18 - - SYM cord-023095-4dannjjm 717 19 9.6 9.6 CD cord-023095-4dannjjm 717 20 ) ) -RRB- cord-023095-4dannjjm 717 21 . . . cord-023095-4dannjjm 718 1 Following follow VBG cord-023095-4dannjjm 718 2 torsemide torsemide JJ cord-023095-4dannjjm 718 3 treatment treatment NN cord-023095-4dannjjm 718 4 , , , cord-023095-4dannjjm 718 5 blood blood NN cord-023095-4dannjjm 718 6 urea urea NN cord-023095-4dannjjm 718 7 nitrogen nitrogen NN cord-023095-4dannjjm 718 8 ( ( -LRB- cord-023095-4dannjjm 718 9 P p NN cord-023095-4dannjjm 718 10 5 5 CD cord-023095-4dannjjm 718 11 0.0028 0.0028 CD cord-023095-4dannjjm 718 12 ) ) -RRB- cord-023095-4dannjjm 718 13 , , , cord-023095-4dannjjm 718 14 albumin albumin NN cord-023095-4dannjjm 718 15 ( ( -LRB- cord-023095-4dannjjm 718 16 P p NN cord-023095-4dannjjm 718 17 5 5 CD cord-023095-4dannjjm 718 18 0.0287 0.0287 CD cord-023095-4dannjjm 718 19 ) ) -RRB- cord-023095-4dannjjm 718 20 , , , cord-023095-4dannjjm 718 21 and and CC cord-023095-4dannjjm 718 22 albumin albumin NN cord-023095-4dannjjm 718 23 : : : cord-023095-4dannjjm 718 24 globulin globulin NN cord-023095-4dannjjm 718 25 ratio ratio NN cord-023095-4dannjjm 718 26 ( ( -LRB- cord-023095-4dannjjm 718 27 P p NN cord-023095-4dannjjm 718 28 5 5 CD cord-023095-4dannjjm 718 29 0.0012 0.0012 CD cord-023095-4dannjjm 718 30 ) ) -RRB- cord-023095-4dannjjm 718 31 were be VBD cord-023095-4dannjjm 718 32 significantly significantly RB cord-023095-4dannjjm 718 33 increased increase VBN cord-023095-4dannjjm 718 34 , , , cord-023095-4dannjjm 718 35 and and CC cord-023095-4dannjjm 718 36 urine urine VB cord-023095-4dannjjm 718 37 specific specific JJ cord-023095-4dannjjm 718 38 gravity gravity NN cord-023095-4dannjjm 718 39 ( ( -LRB- cord-023095-4dannjjm 718 40 P p NN cord-023095-4dannjjm 718 41 5 5 CD cord-023095-4dannjjm 718 42 0.0062 0.0062 CD cord-023095-4dannjjm 718 43 ) ) -RRB- cord-023095-4dannjjm 718 44 and and CC cord-023095-4dannjjm 718 45 chloride chloride NN cord-023095-4dannjjm 718 46 ( ( -LRB- cord-023095-4dannjjm 718 47 P p NN cord-023095-4dannjjm 718 48 5 5 CD cord-023095-4dannjjm 718 49 0.0051 0.0051 CD cord-023095-4dannjjm 718 50 ) ) -RRB- cord-023095-4dannjjm 718 51 were be VBD cord-023095-4dannjjm 718 52 significantly significantly RB cord-023095-4dannjjm 718 53 decreased decrease VBN cord-023095-4dannjjm 718 54 as as IN cord-023095-4dannjjm 718 55 compared compare VBN cord-023095-4dannjjm 718 56 to to IN cord-023095-4dannjjm 718 57 baseline baseline NN cord-023095-4dannjjm 718 58 and/or and/or CC cord-023095-4dannjjm 718 59 furosemide furosemide NN cord-023095-4dannjjm 718 60 dosing dosing NN cord-023095-4dannjjm 718 61 ( ( -LRB- cord-023095-4dannjjm 718 62 one one CD cord-023095-4dannjjm 718 63 - - HYPH cord-023095-4dannjjm 718 64 way way NN cord-023095-4dannjjm 718 65 ANOVA anova NN cord-023095-4dannjjm 718 66 with with IN cord-023095-4dannjjm 718 67 Bonferroni Bonferroni NNP cord-023095-4dannjjm 718 68 correction correction NN cord-023095-4dannjjm 718 69 ) ) -RRB- cord-023095-4dannjjm 718 70 . . . cord-023095-4dannjjm 719 1 No no DT cord-023095-4dannjjm 719 2 differences difference NNS cord-023095-4dannjjm 719 3 in in IN cord-023095-4dannjjm 719 4 QOL QOL NNP cord-023095-4dannjjm 719 5 were be VBD cord-023095-4dannjjm 719 6 found find VBN cord-023095-4dannjjm 719 7 . . . cord-023095-4dannjjm 720 1 Results result NNS cord-023095-4dannjjm 720 2 indicate indicate VBP cord-023095-4dannjjm 720 3 that that IN cord-023095-4dannjjm 720 4 torsemide torsemide NN cord-023095-4dannjjm 720 5 is be VBZ cord-023095-4dannjjm 720 6 equivalent equivalent JJ cord-023095-4dannjjm 720 7 to to TO cord-023095-4dannjjm 720 8 furosemide furosemide VB cord-023095-4dannjjm 720 9 at at IN cord-023095-4dannjjm 720 10 controlling control VBG cord-023095-4dannjjm 720 11 clinical clinical JJ cord-023095-4dannjjm 720 12 heart heart NN cord-023095-4dannjjm 720 13 failure failure NN cord-023095-4dannjjm 720 14 in in IN cord-023095-4dannjjm 720 15 dogs dog NNS cord-023095-4dannjjm 720 16 , , , cord-023095-4dannjjm 720 17 and and CC cord-023095-4dannjjm 720 18 might may MD cord-023095-4dannjjm 720 19 in in IN cord-023095-4dannjjm 720 20 fact fact NN cord-023095-4dannjjm 720 21 , , , cord-023095-4dannjjm 720 22 achieve achieve VB cord-023095-4dannjjm 720 23 greater great JJR cord-023095-4dannjjm 720 24 diuresis diuresis NN cord-023095-4dannjjm 720 25 vs. vs. IN cord-023095-4dannjjm 720 26 furosemide furosemide NN cord-023095-4dannjjm 720 27 . . . cord-023095-4dannjjm 721 1 Larger large JJR cord-023095-4dannjjm 721 2 clinical clinical JJ cord-023095-4dannjjm 721 3 trials trial NNS cord-023095-4dannjjm 721 4 evaluating evaluate VBG cord-023095-4dannjjm 721 5 furosemide furosemide NN cord-023095-4dannjjm 721 6 resistance resistance NN cord-023095-4dannjjm 722 1 and/or and/or CC cord-023095-4dannjjm 722 2 torsemide torsemide RB cord-023095-4dannjjm 722 3 as as IN cord-023095-4dannjjm 722 4 a a DT cord-023095-4dannjjm 722 5 first first JJ cord-023095-4dannjjm 722 6 - - HYPH cord-023095-4dannjjm 722 7 line line NN cord-023095-4dannjjm 722 8 loop loop NN cord-023095-4dannjjm 722 9 diuretic diuretic NN cord-023095-4dannjjm 722 10 for for IN cord-023095-4dannjjm 722 11 congestive congestive JJ cord-023095-4dannjjm 722 12 heart heart NN cord-023095-4dannjjm 722 13 failure failure NN cord-023095-4dannjjm 722 14 in in IN cord-023095-4dannjjm 722 15 dogs dog NNS cord-023095-4dannjjm 722 16 with with IN cord-023095-4dannjjm 722 17 heart heart NN cord-023095-4dannjjm 722 18 failure failure NN cord-023095-4dannjjm 723 1 are be VBP cord-023095-4dannjjm 723 2 warranted warrant VBN cord-023095-4dannjjm 723 3 . . . cord-023095-4dannjjm 724 1 The the DT cord-023095-4dannjjm 724 2 purpose purpose NN cord-023095-4dannjjm 724 3 of of IN cord-023095-4dannjjm 724 4 this this DT cord-023095-4dannjjm 724 5 study study NN cord-023095-4dannjjm 724 6 was be VBD cord-023095-4dannjjm 724 7 to to TO cord-023095-4dannjjm 724 8 investigate investigate VB cord-023095-4dannjjm 724 9 the the DT cord-023095-4dannjjm 724 10 feasibility feasibility NN cord-023095-4dannjjm 724 11 of of IN cord-023095-4dannjjm 724 12 speckle speckle NN cord-023095-4dannjjm 724 13 tracking tracking NN cord-023095-4dannjjm 724 14 echocardiography echocardiography NN cord-023095-4dannjjm 724 15 ( ( -LRB- cord-023095-4dannjjm 724 16 STE STE NNP cord-023095-4dannjjm 724 17 ) ) -RRB- cord-023095-4dannjjm 724 18 in in IN cord-023095-4dannjjm 724 19 healthy healthy JJ cord-023095-4dannjjm 724 20 cats cat NNS cord-023095-4dannjjm 724 21 and and CC cord-023095-4dannjjm 724 22 to to TO cord-023095-4dannjjm 724 23 determine determine VB cord-023095-4dannjjm 724 24 whether whether IN cord-023095-4dannjjm 724 25 or or CC cord-023095-4dannjjm 724 26 not not RB cord-023095-4dannjjm 724 27 it -PRON- PRP cord-023095-4dannjjm 724 28 can can MD cord-023095-4dannjjm 724 29 detect detect VB cord-023095-4dannjjm 724 30 myocardial myocardial JJ cord-023095-4dannjjm 724 31 dysfunction dysfunction NN cord-023095-4dannjjm 724 32 in in IN cord-023095-4dannjjm 724 33 cats cat NNS cord-023095-4dannjjm 724 34 with with IN cord-023095-4dannjjm 724 35 diseased diseased JJ cord-023095-4dannjjm 724 36 heart heart NN cord-023095-4dannjjm 724 37 . . . cord-023095-4dannjjm 725 1 Radial radial JJ cord-023095-4dannjjm 725 2 and and CC cord-023095-4dannjjm 725 3 circumferential circumferential JJ cord-023095-4dannjjm 725 4 strain strain NN cord-023095-4dannjjm 725 5 and and CC cord-023095-4dannjjm 725 6 strain strain NN cord-023095-4dannjjm 725 7 rate rate NN cord-023095-4dannjjm 725 8 were be VBD cord-023095-4dannjjm 725 9 measured measure VBN cord-023095-4dannjjm 725 10 by by IN cord-023095-4dannjjm 725 11 STE STE NNP cord-023095-4dannjjm 725 12 using use VBG cord-023095-4dannjjm 725 13 left left JJ cord-023095-4dannjjm 725 14 ventricle ventricle NN cord-023095-4dannjjm 725 15 short short JJ cord-023095-4dannjjm 725 16 - - HYPH cord-023095-4dannjjm 725 17 axis axis NN cord-023095-4dannjjm 725 18 view view NN cord-023095-4dannjjm 725 19 in in IN cord-023095-4dannjjm 725 20 clinically clinically RB cord-023095-4dannjjm 725 21 healthy healthy JJ cord-023095-4dannjjm 725 22 cats cat NNS cord-023095-4dannjjm 725 23 . . . cord-023095-4dannjjm 726 1 Eighteen eighteen CD cord-023095-4dannjjm 726 2 cats cat NNS cord-023095-4dannjjm 726 3 with with IN cord-023095-4dannjjm 726 4 HCM HCM NNP cord-023095-4dannjjm 726 5 whose whose WP$ cord-023095-4dannjjm 726 6 LV LV NNP cord-023095-4dannjjm 726 7 thickness thickness NN cord-023095-4dannjjm 726 8 at at IN cord-023095-4dannjjm 726 9 end end NN cord-023095-4dannjjm 726 10 - - HYPH cord-023095-4dannjjm 726 11 diastole diastole NN cord-023095-4dannjjm 726 12 with with IN cord-023095-4dannjjm 726 13 6 6 CD cord-023095-4dannjjm 726 14 mm mm NNS cord-023095-4dannjjm 726 15 or or CC cord-023095-4dannjjm 726 16 more more JJR cord-023095-4dannjjm 726 17 were be VBD cord-023095-4dannjjm 726 18 evaluated evaluate VBN cord-023095-4dannjjm 726 19 with with IN cord-023095-4dannjjm 726 20 STE STE NNP cord-023095-4dannjjm 726 21 analysis analysis NN cord-023095-4dannjjm 726 22 , , , cord-023095-4dannjjm 726 23 and and CC cord-023095-4dannjjm 726 24 compared compare VBN cord-023095-4dannjjm 726 25 with with IN cord-023095-4dannjjm 726 26 healthy healthy JJ cord-023095-4dannjjm 726 27 cats cat NNS cord-023095-4dannjjm 726 28 . . . cord-023095-4dannjjm 727 1 Index index NN cord-023095-4dannjjm 727 2 of of IN cord-023095-4dannjjm 727 3 left left JJ cord-023095-4dannjjm 727 4 ventricular ventricular JJ cord-023095-4dannjjm 727 5 synchrony synchrony NN cord-023095-4dannjjm 727 6 ( ( -LRB- cord-023095-4dannjjm 727 7 Trs Trs NNP cord-023095-4dannjjm 727 8 - - HYPH cord-023095-4dannjjm 727 9 SD SD NNP cord-023095-4dannjjm 727 10 ) ) -RRB- cord-023095-4dannjjm 727 11 was be VBD cord-023095-4dannjjm 727 12 also also RB cord-023095-4dannjjm 727 13 assessed assess VBN cord-023095-4dannjjm 727 14 in in IN cord-023095-4dannjjm 727 15 cats cat NNS cord-023095-4dannjjm 727 16 with with IN cord-023095-4dannjjm 727 17 HCM HCM NNP cord-023095-4dannjjm 727 18 , , , cord-023095-4dannjjm 727 19 and and CC cord-023095-4dannjjm 727 20 compared compare VBN cord-023095-4dannjjm 727 21 to to IN cord-023095-4dannjjm 727 22 healthy healthy JJ cord-023095-4dannjjm 727 23 subjects subject NNS cord-023095-4dannjjm 727 24 . . . cord-023095-4dannjjm 728 1 STE STE NNP cord-023095-4dannjjm 728 2 resulted result VBD cord-023095-4dannjjm 728 3 in in IN cord-023095-4dannjjm 728 4 technically technically RB cord-023095-4dannjjm 728 5 adequate adequate JJ cord-023095-4dannjjm 728 6 images image NNS cord-023095-4dannjjm 728 7 in in IN cord-023095-4dannjjm 728 8 100 100 CD cord-023095-4dannjjm 728 9 % % NN cord-023095-4dannjjm 728 10 of of IN cord-023095-4dannjjm 728 11 the the DT cord-023095-4dannjjm 728 12 cats cat NNS cord-023095-4dannjjm 728 13 . . . cord-023095-4dannjjm 729 1 Fusions fusion NNS cord-023095-4dannjjm 729 2 of of IN cord-023095-4dannjjm 729 3 early early JJ cord-023095-4dannjjm 729 4 and and CC cord-023095-4dannjjm 729 5 late late JJ cord-023095-4dannjjm 729 6 diastolic diastolic NN cord-023095-4dannjjm 729 7 ( ( -LRB- cord-023095-4dannjjm 729 8 E e NN cord-023095-4dannjjm 729 9 and and CC cord-023095-4dannjjm 729 10 A a NN cord-023095-4dannjjm 729 11 ) ) -RRB- cord-023095-4dannjjm 729 12 wave wave NN cord-023095-4dannjjm 729 13 in in IN cord-023095-4dannjjm 729 14 strain strain NN cord-023095-4dannjjm 729 15 rate rate NN cord-023095-4dannjjm 729 16 were be VBD cord-023095-4dannjjm 729 17 seen see VBN cord-023095-4dannjjm 729 18 in in IN cord-023095-4dannjjm 729 19 3 3 CD cord-023095-4dannjjm 729 20 of of IN cord-023095-4dannjjm 729 21 16 16 CD cord-023095-4dannjjm 729 22 cats cat NNS cord-023095-4dannjjm 729 23 . . . cord-023095-4dannjjm 730 1 Percent percent NN cord-023095-4dannjjm 730 2 errors error NNS cord-023095-4dannjjm 730 3 in in IN cord-023095-4dannjjm 730 4 analysis analysis NN cord-023095-4dannjjm 730 5 with with IN cord-023095-4dannjjm 730 6 or or CC cord-023095-4dannjjm 730 7 without without IN cord-023095-4dannjjm 730 8 simultaneous simultaneous JJ cord-023095-4dannjjm 730 9 ECG ECG NNP cord-023095-4dannjjm 730 10 monitoring monitoring NN cord-023095-4dannjjm 730 11 were be VBD cord-023095-4dannjjm 730 12 5.3 5.3 CD cord-023095-4dannjjm 730 13 - - SYM cord-023095-4dannjjm 730 14 14.7 14.7 CD cord-023095-4dannjjm 730 15 % % NN cord-023095-4dannjjm 730 16 in in IN cord-023095-4dannjjm 730 17 all all DT cord-023095-4dannjjm 730 18 parameters parameter NNS cord-023095-4dannjjm 730 19 . . . cord-023095-4dannjjm 731 1 Inter Inter NNP cord-023095-4dannjjm 731 2 - - : cord-023095-4dannjjm 731 3 and and CC cord-023095-4dannjjm 731 4 intraobserver intraobserver NNP cord-023095-4dannjjm 731 5 variability variability NN cord-023095-4dannjjm 731 6 of of IN cord-023095-4dannjjm 731 7 STE STE NNP cord-023095-4dannjjm 731 8 parameters parameter NNS cord-023095-4dannjjm 731 9 in in IN cord-023095-4dannjjm 731 10 healthy healthy JJ cord-023095-4dannjjm 731 11 cats cat NNS cord-023095-4dannjjm 731 12 was be VBD cord-023095-4dannjjm 731 13 minimal minimal JJ cord-023095-4dannjjm 731 14 ( ( -LRB- cord-023095-4dannjjm 731 15 4.1 4.1 CD cord-023095-4dannjjm 731 16 - - SYM cord-023095-4dannjjm 731 17 15.6 15.6 CD cord-023095-4dannjjm 731 18 % % NN cord-023095-4dannjjm 731 19 ) ) -RRB- cord-023095-4dannjjm 731 20 except except IN cord-023095-4dannjjm 731 21 for for IN cord-023095-4dannjjm 731 22 the the DT cord-023095-4dannjjm 731 23 systolic systolic JJ cord-023095-4dannjjm 731 24 circumferential circumferential JJ cord-023095-4dannjjm 731 25 strain strain NN cord-023095-4dannjjm 731 26 rate rate NN cord-023095-4dannjjm 731 27 . . . cord-023095-4dannjjm 732 1 Sedation sedation NN cord-023095-4dannjjm 732 2 using use VBG cord-023095-4dannjjm 732 3 buprenorphine buprenorphine NN cord-023095-4dannjjm 732 4 and and CC cord-023095-4dannjjm 732 5 acepromazine acepromazine NN cord-023095-4dannjjm 732 6 did do VBD cord-023095-4dannjjm 732 7 not not RB cord-023095-4dannjjm 732 8 affect affect VB cord-023095-4dannjjm 732 9 any any DT cord-023095-4dannjjm 732 10 STE STE NNP cord-023095-4dannjjm 732 11 parameter parameter NN cord-023095-4dannjjm 732 12 . . . cord-023095-4dannjjm 733 1 E e NN cord-023095-4dannjjm 733 2 wave wave NN cord-023095-4dannjjm 733 3 in in IN cord-023095-4dannjjm 733 4 radial radial JJ cord-023095-4dannjjm 733 5 and and CC cord-023095-4dannjjm 733 6 circumferential circumferential JJ cord-023095-4dannjjm 733 7 strain strain NN cord-023095-4dannjjm 733 8 rate rate NN cord-023095-4dannjjm 733 9 of of IN cord-023095-4dannjjm 733 10 HCM HCM NNP cord-023095-4dannjjm 733 11 cats cat NNS cord-023095-4dannjjm 733 12 was be VBD cord-023095-4dannjjm 733 13 significantly significantly RB cord-023095-4dannjjm 733 14 decreased decrease VBN cord-023095-4dannjjm 733 15 compared compare VBN cord-023095-4dannjjm 733 16 with with IN cord-023095-4dannjjm 733 17 healthy healthy JJ cord-023095-4dannjjm 733 18 cats cat NNS cord-023095-4dannjjm 733 19 . . . cord-023095-4dannjjm 734 1 No no DT cord-023095-4dannjjm 734 2 significant significant JJ cord-023095-4dannjjm 734 3 difference difference NN cord-023095-4dannjjm 734 4 was be VBD cord-023095-4dannjjm 734 5 seen see VBN cord-023095-4dannjjm 734 6 in in IN cord-023095-4dannjjm 734 7 Trs Trs NNP cord-023095-4dannjjm 734 8 - - HYPH cord-023095-4dannjjm 734 9 SD SD NNP cord-023095-4dannjjm 734 10 . . . cord-023095-4dannjjm 735 1 STE STE NNP cord-023095-4dannjjm 735 2 analysis analysis NN cord-023095-4dannjjm 735 3 was be VBD cord-023095-4dannjjm 735 4 considered consider VBN cord-023095-4dannjjm 735 5 clinically clinically RB cord-023095-4dannjjm 735 6 feasible feasible JJ cord-023095-4dannjjm 735 7 to to TO cord-023095-4dannjjm 735 8 assess assess VB cord-023095-4dannjjm 735 9 cardiac cardiac JJ cord-023095-4dannjjm 735 10 function function NN cord-023095-4dannjjm 735 11 in in IN cord-023095-4dannjjm 735 12 cats cat NNS cord-023095-4dannjjm 735 13 , , , cord-023095-4dannjjm 735 14 and and CC cord-023095-4dannjjm 735 15 could could MD cord-023095-4dannjjm 735 16 detect detect VB cord-023095-4dannjjm 735 17 myocardial myocardial JJ cord-023095-4dannjjm 735 18 dysfunction dysfunction NN cord-023095-4dannjjm 735 19 in in IN cord-023095-4dannjjm 735 20 cats cat NNS cord-023095-4dannjjm 735 21 with with IN cord-023095-4dannjjm 735 22 HCM HCM NNP cord-023095-4dannjjm 735 23 . . . cord-023095-4dannjjm 736 1 Further further JJ cord-023095-4dannjjm 736 2 study study NN cord-023095-4dannjjm 736 3 is be VBZ cord-023095-4dannjjm 736 4 warranted warrant VBN cord-023095-4dannjjm 736 5 to to TO cord-023095-4dannjjm 736 6 investigate investigate VB cord-023095-4dannjjm 736 7 to to TO cord-023095-4dannjjm 736 8 assess assess VB cord-023095-4dannjjm 736 9 whether whether IN cord-023095-4dannjjm 736 10 or or CC cord-023095-4dannjjm 736 11 not not RB cord-023095-4dannjjm 736 12 STE STE NNP cord-023095-4dannjjm 736 13 can can MD cord-023095-4dannjjm 736 14 differentiate differentiate VB cord-023095-4dannjjm 736 15 the the DT cord-023095-4dannjjm 736 16 etiology etiology NN cord-023095-4dannjjm 736 17 of of IN cord-023095-4dannjjm 736 18 left left JJ cord-023095-4dannjjm 736 19 ventricular ventricular JJ cord-023095-4dannjjm 736 20 concentric concentric JJ cord-023095-4dannjjm 736 21 hypertrophy hypertrophy NN cord-023095-4dannjjm 736 22 since since IN cord-023095-4dannjjm 736 23 it -PRON- PRP cord-023095-4dannjjm 736 24 is be VBZ cord-023095-4dannjjm 736 25 clinically clinically RB cord-023095-4dannjjm 736 26 important important JJ cord-023095-4dannjjm 736 27 . . . cord-023095-4dannjjm 737 1 Carvedilol Carvedilol NNP cord-023095-4dannjjm 737 2 , , , cord-023095-4dannjjm 737 3 a a DT cord-023095-4dannjjm 737 4 3rd 3rd JJ cord-023095-4dannjjm 737 5 generation generation NN cord-023095-4dannjjm 737 6 non non JJ cord-023095-4dannjjm 737 7 - - JJ cord-023095-4dannjjm 737 8 selective selective JJ cord-023095-4dannjjm 737 9 beta beta NN cord-023095-4dannjjm 737 10 - - HYPH cord-023095-4dannjjm 737 11 blocker blocker NN cord-023095-4dannjjm 737 12 with with IN cord-023095-4dannjjm 737 13 ancillary ancillary JJ cord-023095-4dannjjm 737 14 alpha alpha NN cord-023095-4dannjjm 737 15 1 1 CD cord-023095-4dannjjm 737 16 -blocking -blocking NN cord-023095-4dannjjm 737 17 and and CC cord-023095-4dannjjm 737 18 antioxidant antioxidant NN cord-023095-4dannjjm 737 19 properties property NNS cord-023095-4dannjjm 737 20 may may MD cord-023095-4dannjjm 737 21 have have VB cord-023095-4dannjjm 737 22 therapeutic therapeutic JJ cord-023095-4dannjjm 737 23 implications implication NNS cord-023095-4dannjjm 737 24 for for IN cord-023095-4dannjjm 737 25 multiple multiple JJ cord-023095-4dannjjm 737 26 diseases disease NNS cord-023095-4dannjjm 737 27 in in IN cord-023095-4dannjjm 737 28 cats cat NNS cord-023095-4dannjjm 737 29 ; ; : cord-023095-4dannjjm 737 30 however however RB cord-023095-4dannjjm 737 31 , , , cord-023095-4dannjjm 737 32 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 737 33 and and CC cord-023095-4dannjjm 737 34 bioavailability bioavailability NN cord-023095-4dannjjm 737 35 of of IN cord-023095-4dannjjm 737 36 commercially commercially RB cord-023095-4dannjjm 737 37 prepared prepare VBN cord-023095-4dannjjm 737 38 oral oral JJ cord-023095-4dannjjm 737 39 carvedilol carvedilol NN cord-023095-4dannjjm 737 40 has have VBZ cord-023095-4dannjjm 737 41 not not RB cord-023095-4dannjjm 737 42 been be VBN cord-023095-4dannjjm 737 43 determined determine VBN cord-023095-4dannjjm 737 44 . . . cord-023095-4dannjjm 738 1 HPLC HPLC NNP cord-023095-4dannjjm 738 2 for for IN cord-023095-4dannjjm 738 3 carvedilol carvedilol NN cord-023095-4dannjjm 738 4 measurement measurement NN cord-023095-4dannjjm 738 5 in in IN cord-023095-4dannjjm 738 6 feline feline JJ cord-023095-4dannjjm 738 7 plasma plasma NN cord-023095-4dannjjm 738 8 was be VBD cord-023095-4dannjjm 738 9 validated validate VBN cord-023095-4dannjjm 738 10 and and CC cord-023095-4dannjjm 738 11 standardization standardization NN cord-023095-4dannjjm 738 12 curves curve NNS cord-023095-4dannjjm 738 13 created create VBN cord-023095-4dannjjm 738 14 . . . cord-023095-4dannjjm 739 1 The the DT cord-023095-4dannjjm 739 2 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 739 3 ( ( -LRB- cord-023095-4dannjjm 739 4 PK PK NNP cord-023095-4dannjjm 739 5 ) ) -RRB- cord-023095-4dannjjm 739 6 of of IN cord-023095-4dannjjm 739 7 carvedilol carvedilol NNP cord-023095-4dannjjm 739 8 was be VBD cord-023095-4dannjjm 739 9 evaluated evaluate VBN cord-023095-4dannjjm 739 10 in in IN cord-023095-4dannjjm 739 11 5 5 CD cord-023095-4dannjjm 739 12 apparently apparently RB cord-023095-4dannjjm 739 13 healthy healthy JJ cord-023095-4dannjjm 739 14 male male JJ cord-023095-4dannjjm 739 15 neutered neuter VBN cord-023095-4dannjjm 739 16 adult adult NN cord-023095-4dannjjm 739 17 cats cat NNS cord-023095-4dannjjm 739 18 ( ( -LRB- cord-023095-4dannjjm 739 19 average average JJ cord-023095-4dannjjm 739 20 weight weight NN cord-023095-4dannjjm 739 21 of of IN cord-023095-4dannjjm 739 22 5 5 CD cord-023095-4dannjjm 739 23 kg kg NN cord-023095-4dannjjm 739 24 ) ) -RRB- cord-023095-4dannjjm 739 25 following follow VBG cord-023095-4dannjjm 739 26 single single JJ cord-023095-4dannjjm 739 27 dose dose NN cord-023095-4dannjjm 739 28 intravenous intravenous NN cord-023095-4dannjjm 739 29 ( ( -LRB- cord-023095-4dannjjm 739 30 IV IV NNP cord-023095-4dannjjm 739 31 ) ) -RRB- cord-023095-4dannjjm 739 32 of of IN cord-023095-4dannjjm 739 33 0.5 0.5 CD cord-023095-4dannjjm 739 34 mg mg NNP cord-023095-4dannjjm 739 35 / / SYM cord-023095-4dannjjm 739 36 kg kg NNS cord-023095-4dannjjm 739 37 and and CC cord-023095-4dannjjm 739 38 single single JJ cord-023095-4dannjjm 739 39 dose dose NN cord-023095-4dannjjm 739 40 oral oral JJ cord-023095-4dannjjm 739 41 administration administration NN cord-023095-4dannjjm 739 42 of of IN cord-023095-4dannjjm 739 43 1.6 1.6 CD cord-023095-4dannjjm 739 44 to to TO cord-023095-4dannjjm 739 45 2.0 2.0 CD cord-023095-4dannjjm 739 46 mg mg NNS cord-023095-4dannjjm 739 47 / / SYM cord-023095-4dannjjm 739 48 kg kg NN cord-023095-4dannjjm 739 49 . . . cord-023095-4dannjjm 740 1 Concentrations concentration NNS cord-023095-4dannjjm 740 2 of of IN cord-023095-4dannjjm 740 3 the the DT cord-023095-4dannjjm 740 4 active active JJ cord-023095-4dannjjm 740 5 parent parent NN cord-023095-4dannjjm 740 6 compound compound NN cord-023095-4dannjjm 740 7 , , , cord-023095-4dannjjm 740 8 carvedilol carvedilol NN cord-023095-4dannjjm 740 9 , , , cord-023095-4dannjjm 740 10 were be VBD cord-023095-4dannjjm 740 11 detected detect VBN cord-023095-4dannjjm 740 12 in in IN cord-023095-4dannjjm 740 13 plasma plasma NN cord-023095-4dannjjm 740 14 using use VBG cord-023095-4dannjjm 740 15 HPLC HPLC NNP cord-023095-4dannjjm 740 16 analysis analysis NN cord-023095-4dannjjm 740 17 . . . cord-023095-4dannjjm 741 1 Lower low JJR cord-023095-4dannjjm 741 2 limit limit NN cord-023095-4dannjjm 741 3 of of IN cord-023095-4dannjjm 741 4 quantification quantification NN cord-023095-4dannjjm 741 5 was be VBD cord-023095-4dannjjm 741 6 5 5 CD cord-023095-4dannjjm 741 7 ng ng NN cord-023095-4dannjjm 741 8 / / SYM cord-023095-4dannjjm 741 9 ml ml NN cord-023095-4dannjjm 741 10 . . . cord-023095-4dannjjm 742 1 The the DT cord-023095-4dannjjm 742 2 mean mean JJ cord-023095-4dannjjm 742 3 peak peak NN cord-023095-4dannjjm 742 4 concentration concentration NN cord-023095-4dannjjm 742 5 after after IN cord-023095-4dannjjm 742 6 IV IV NNP cord-023095-4dannjjm 742 7 administration administration NN cord-023095-4dannjjm 742 8 of of IN cord-023095-4dannjjm 742 9 carvedilol carvedilol NNP cord-023095-4dannjjm 742 10 was be VBD cord-023095-4dannjjm 742 11 8639 8639 CD cord-023095-4dannjjm 742 12 ng ng NN cord-023095-4dannjjm 742 13 / / SYM cord-023095-4dannjjm 742 14 mL ml NN cord-023095-4dannjjm 742 15 ( ( -LRB- cord-023095-4dannjjm 742 16 range range NN cord-023095-4dannjjm 742 17 , , , cord-023095-4dannjjm 742 18 901 901 CD cord-023095-4dannjjm 742 19 to to IN cord-023095-4dannjjm 742 20 8648 8648 CD cord-023095-4dannjjm 742 21 ) ) -RRB- cord-023095-4dannjjm 742 22 , , , cord-023095-4dannjjm 742 23 elimination elimination NN cord-023095-4dannjjm 742 24 half half JJ cord-023095-4dannjjm 742 25 - - HYPH cord-023095-4dannjjm 742 26 life life NN cord-023095-4dannjjm 742 27 was be VBD cord-023095-4dannjjm 742 28 2.9 2.9 CD cord-023095-4dannjjm 742 29 hours hour NNS cord-023095-4dannjjm 742 30 ( ( -LRB- cord-023095-4dannjjm 742 31 range range NN cord-023095-4dannjjm 742 32 , , , cord-023095-4dannjjm 742 33 2.0 2.0 CD cord-023095-4dannjjm 742 34 to to IN cord-023095-4dannjjm 742 35 5.4 5.4 CD cord-023095-4dannjjm 742 36 ) ) -RRB- cord-023095-4dannjjm 742 37 , , , cord-023095-4dannjjm 742 38 and and CC cord-023095-4dannjjm 742 39 clearance clearance NN cord-023095-4dannjjm 742 40 was be VBD cord-023095-4dannjjm 742 41 0.35 0.35 CD cord-023095-4dannjjm 742 42 L l NN cord-023095-4dannjjm 742 43 / / SYM cord-023095-4dannjjm 742 44 hr hr NN cord-023095-4dannjjm 742 45 / / SYM cord-023095-4dannjjm 742 46 kg kg NNS cord-023095-4dannjjm 742 47 . . . cord-023095-4dannjjm 743 1 The the DT cord-023095-4dannjjm 743 2 volume volume NN cord-023095-4dannjjm 743 3 of of IN cord-023095-4dannjjm 743 4 distribution distribution NN cord-023095-4dannjjm 743 5 was be VBD cord-023095-4dannjjm 743 6 1.18 1.18 CD cord-023095-4dannjjm 743 7 L l NN cord-023095-4dannjjm 743 8 / / SYM cord-023095-4dannjjm 743 9 hr hr NN cord-023095-4dannjjm 743 10 . . . cord-023095-4dannjjm 744 1 After after IN cord-023095-4dannjjm 744 2 a a DT cord-023095-4dannjjm 744 3 single single JJ cord-023095-4dannjjm 744 4 oral oral JJ cord-023095-4dannjjm 744 5 administration administration NN cord-023095-4dannjjm 744 6 of of IN cord-023095-4dannjjm 744 7 carvedilol carvedilol NNP cord-023095-4dannjjm 744 8 , , , cord-023095-4dannjjm 744 9 the the DT cord-023095-4dannjjm 744 10 time time NN cord-023095-4dannjjm 744 11 to to TO cord-023095-4dannjjm 744 12 peak peak VB cord-023095-4dannjjm 744 13 plasma plasma NN cord-023095-4dannjjm 744 14 concentration concentration NN cord-023095-4dannjjm 744 15 was be VBD cord-023095-4dannjjm 744 16 60 60 CD cord-023095-4dannjjm 744 17 minutes minute NNS cord-023095-4dannjjm 744 18 ( ( -LRB- cord-023095-4dannjjm 744 19 range range NN cord-023095-4dannjjm 744 20 , , , cord-023095-4dannjjm 744 21 30 30 CD cord-023095-4dannjjm 744 22 to to TO cord-023095-4dannjjm 744 23 90 90 CD cord-023095-4dannjjm 744 24 minutes minute NNS cord-023095-4dannjjm 744 25 ) ) -RRB- cord-023095-4dannjjm 744 26 and and CC cord-023095-4dannjjm 744 27 the the DT cord-023095-4dannjjm 744 28 mean mean JJ cord-023095-4dannjjm 744 29 residual residual JJ cord-023095-4dannjjm 744 30 time time NN cord-023095-4dannjjm 744 31 was be VBD cord-023095-4dannjjm 744 32 4.8 4.8 CD cord-023095-4dannjjm 744 33 hours hour NNS cord-023095-4dannjjm 744 34 . . . cord-023095-4dannjjm 745 1 The the DT cord-023095-4dannjjm 745 2 half half JJ cord-023095-4dannjjm 745 3 life life NN cord-023095-4dannjjm 745 4 was be VBD cord-023095-4dannjjm 745 5 4.44 4.44 CD cord-023095-4dannjjm 745 6 hours hour NNS cord-023095-4dannjjm 745 7 . . . cord-023095-4dannjjm 746 1 Maximal maximal JJ cord-023095-4dannjjm 746 2 concentration concentration NN cord-023095-4dannjjm 746 3 294 294 CD cord-023095-4dannjjm 746 4 ng/ ng/ NN cord-023095-4dannjjm 746 5 mL ml NN cord-023095-4dannjjm 747 1 and and CC cord-023095-4dannjjm 747 2 the the DT cord-023095-4dannjjm 747 3 mean mean JJ cord-023095-4dannjjm 747 4 bioavailability bioavailability NN cord-023095-4dannjjm 747 5 was be VBD cord-023095-4dannjjm 747 6 15.7 15.7 CD cord-023095-4dannjjm 747 7 % % NN cord-023095-4dannjjm 747 8 with with IN cord-023095-4dannjjm 747 9 a a DT cord-023095-4dannjjm 747 10 median median NN cord-023095-4dannjjm 747 11 of of IN cord-023095-4dannjjm 747 12 9.97 9.97 CD cord-023095-4dannjjm 747 13 % % NN cord-023095-4dannjjm 747 14 ( ( -LRB- cord-023095-4dannjjm 747 15 range range NN cord-023095-4dannjjm 747 16 , , , cord-023095-4dannjjm 747 17 4.7 4.7 CD cord-023095-4dannjjm 747 18 % % NN cord-023095-4dannjjm 747 19 to to IN cord-023095-4dannjjm 747 20 46 46 CD cord-023095-4dannjjm 747 21 % % NN cord-023095-4dannjjm 747 22 ) ) -RRB- cord-023095-4dannjjm 747 23 . . . cord-023095-4dannjjm 748 1 These these DT cord-023095-4dannjjm 748 2 data datum NNS cord-023095-4dannjjm 748 3 demonstrate demonstrate VBP cord-023095-4dannjjm 748 4 a a DT cord-023095-4dannjjm 748 5 low low JJ cord-023095-4dannjjm 748 6 bioavailability bioavailability NN cord-023095-4dannjjm 748 7 of of IN cord-023095-4dannjjm 748 8 oral oral JJ cord-023095-4dannjjm 748 9 carvedilol carvedilol NN cord-023095-4dannjjm 748 10 and and CC cord-023095-4dannjjm 748 11 a a DT cord-023095-4dannjjm 748 12 wide wide JJ cord-023095-4dannjjm 748 13 variation variation NN cord-023095-4dannjjm 748 14 in in IN cord-023095-4dannjjm 748 15 cats cat NNS cord-023095-4dannjjm 748 16 . . . cord-023095-4dannjjm 749 1 All all DT cord-023095-4dannjjm 749 2 cats cat NNS cord-023095-4dannjjm 749 3 tolerated tolerate VBD cord-023095-4dannjjm 749 4 the the DT cord-023095-4dannjjm 749 5 oral oral JJ cord-023095-4dannjjm 749 6 dose dose NN cord-023095-4dannjjm 749 7 of of IN cord-023095-4dannjjm 749 8 carvedilol carvedilol NN cord-023095-4dannjjm 749 9 with with IN cord-023095-4dannjjm 749 10 no no DT cord-023095-4dannjjm 749 11 major major JJ cord-023095-4dannjjm 749 12 adverse adverse JJ cord-023095-4dannjjm 749 13 effects effect NNS cord-023095-4dannjjm 749 14 . . . cord-023095-4dannjjm 750 1 Also also RB cord-023095-4dannjjm 750 2 , , , cord-023095-4dannjjm 750 3 a a DT cord-023095-4dannjjm 750 4 mean mean JJ cord-023095-4dannjjm 750 5 residual residual JJ cord-023095-4dannjjm 750 6 time time NN cord-023095-4dannjjm 750 7 of of IN cord-023095-4dannjjm 750 8 4.8 4.8 CD cord-023095-4dannjjm 750 9 hours hour NNS cord-023095-4dannjjm 750 10 would would MD cord-023095-4dannjjm 750 11 suggest suggest VB cord-023095-4dannjjm 750 12 that that IN cord-023095-4dannjjm 750 13 a a DT cord-023095-4dannjjm 750 14 more more RBR cord-023095-4dannjjm 750 15 frequent frequent JJ cord-023095-4dannjjm 750 16 dosing dosing NN cord-023095-4dannjjm 750 17 schedule schedule NN cord-023095-4dannjjm 750 18 may may MD cord-023095-4dannjjm 750 19 be be VB cord-023095-4dannjjm 750 20 required require VBN cord-023095-4dannjjm 750 21 to to TO cord-023095-4dannjjm 750 22 maintain maintain VB cord-023095-4dannjjm 750 23 therapeutic therapeutic JJ cord-023095-4dannjjm 750 24 plasma plasma NN cord-023095-4dannjjm 750 25 levels level NNS cord-023095-4dannjjm 750 26 . . . cord-023095-4dannjjm 751 1 Pharmacodynamic Pharmacodynamic NNP cord-023095-4dannjjm 751 2 studies study NNS cord-023095-4dannjjm 751 3 investigating investigate VBG cord-023095-4dannjjm 751 4 beta beta JJ cord-023095-4dannjjm 751 5 - - HYPH cord-023095-4dannjjm 751 6 adrenergic adrenergic NN cord-023095-4dannjjm 751 7 blockade blockade NN cord-023095-4dannjjm 751 8 duration duration NN cord-023095-4dannjjm 751 9 may may MD cord-023095-4dannjjm 751 10 provide provide VB cord-023095-4dannjjm 751 11 a a DT cord-023095-4dannjjm 751 12 more more RBR cord-023095-4dannjjm 751 13 accurate accurate JJ cord-023095-4dannjjm 751 14 dosing dosing NN cord-023095-4dannjjm 751 15 interval interval NN cord-023095-4dannjjm 751 16 of of IN cord-023095-4dannjjm 751 17 carvedilol carvedilol NN cord-023095-4dannjjm 751 18 . . . cord-023095-4dannjjm 752 1 ABSTRACT abstract JJ cord-023095-4dannjjm 752 2 C-49 C-49 NNP cord-023095-4dannjjm 752 3 EFFECTS effects NN cord-023095-4dannjjm 752 4 OF of IN cord-023095-4dannjjm 752 5 SILDENAFIL SILDENAFIL NNP cord-023095-4dannjjm 752 6 CITRATE CITRATE NNP cord-023095-4dannjjm 752 7 ON on IN cord-023095-4dannjjm 752 8 DOGS dog NNS cord-023095-4dannjjm 752 9 WITH with IN cord-023095-4dannjjm 752 10 EI EI NNP cord-023095-4dannjjm 752 11 - - HYPH cord-023095-4dannjjm 752 12 SENMENGER SENMENGER NNP cord-023095-4dannjjm 752 13 'S 's POS cord-023095-4dannjjm 752 14 SYNDROME syndrome NN cord-023095-4dannjjm 752 15 . . . cord-023095-4dannjjm 753 1 K K NNP cord-023095-4dannjjm 753 2 Nakamura Nakamura NNP cord-023095-4dannjjm 753 3 , , , cord-023095-4dannjjm 753 4 M M NNP cord-023095-4dannjjm 753 5 Yamasaki Yamasaki NNP cord-023095-4dannjjm 753 6 , , , cord-023095-4dannjjm 753 7 H H NNP cord-023095-4dannjjm 753 8 Ohta Ohta NNP cord-023095-4dannjjm 753 9 , , , cord-023095-4dannjjm 753 10 M M NNP cord-023095-4dannjjm 753 11 Takiguchi Takiguchi NNP cord-023095-4dannjjm 753 12 . . . cord-023095-4dannjjm 754 1 Department Department NNP cord-023095-4dannjjm 754 2 of of IN cord-023095-4dannjjm 754 3 Veterinary Veterinary NNP cord-023095-4dannjjm 754 4 Clinical Clinical NNP cord-023095-4dannjjm 754 5 Sciences Sciences NNPS cord-023095-4dannjjm 754 6 , , , cord-023095-4dannjjm 754 7 Graduate Graduate NNP cord-023095-4dannjjm 754 8 School School NNP cord-023095-4dannjjm 754 9 of of IN cord-023095-4dannjjm 754 10 Veterinary Veterinary NNP cord-023095-4dannjjm 754 11 Medicine Medicine NNP cord-023095-4dannjjm 754 12 , , , cord-023095-4dannjjm 754 13 Hokkaido Hokkaido NNP cord-023095-4dannjjm 754 14 University University NNP cord-023095-4dannjjm 754 15 , , , cord-023095-4dannjjm 754 16 Sapporo Sapporo NNP cord-023095-4dannjjm 754 17 , , , cord-023095-4dannjjm 754 18 Hokkaido Hokkaido NNP cord-023095-4dannjjm 754 19 , , , cord-023095-4dannjjm 754 20 Japan Japan NNP cord-023095-4dannjjm 754 21 . . . cord-023095-4dannjjm 755 1 Sildenafil Sildenafil NNP cord-023095-4dannjjm 755 2 has have VBZ cord-023095-4dannjjm 755 3 shown show VBN cord-023095-4dannjjm 755 4 to to TO cord-023095-4dannjjm 755 5 be be VB cord-023095-4dannjjm 755 6 effective effective JJ cord-023095-4dannjjm 755 7 for for IN cord-023095-4dannjjm 755 8 dogs dog NNS cord-023095-4dannjjm 755 9 with with IN cord-023095-4dannjjm 755 10 pulmonary pulmonary JJ cord-023095-4dannjjm 755 11 hypertension hypertension NN cord-023095-4dannjjm 755 12 ; ; : cord-023095-4dannjjm 755 13 however however RB cord-023095-4dannjjm 755 14 , , , cord-023095-4dannjjm 755 15 its -PRON- PRP$ cord-023095-4dannjjm 755 16 efficacy efficacy NN cord-023095-4dannjjm 755 17 for for IN cord-023095-4dannjjm 755 18 dogs dog NNS cord-023095-4dannjjm 755 19 with with IN cord-023095-4dannjjm 755 20 Eisenmenger Eisenmenger NNP cord-023095-4dannjjm 755 21 's 's POS cord-023095-4dannjjm 755 22 syndrome syndrome NN cord-023095-4dannjjm 755 23 ( ( -LRB- cord-023095-4dannjjm 755 24 ES ES NNP cord-023095-4dannjjm 755 25 ) ) -RRB- cord-023095-4dannjjm 755 26 and and CC cord-023095-4dannjjm 755 27 secondary secondary JJ cord-023095-4dannjjm 755 28 erythrocytosis erythrocytosis NN cord-023095-4dannjjm 755 29 has have VBZ cord-023095-4dannjjm 755 30 not not RB cord-023095-4dannjjm 755 31 yet yet RB cord-023095-4dannjjm 755 32 been be VBN cord-023095-4dannjjm 755 33 determined determine VBN cord-023095-4dannjjm 755 34 . . . cord-023095-4dannjjm 756 1 The the DT cord-023095-4dannjjm 756 2 objective objective NN cord-023095-4dannjjm 756 3 of of IN cord-023095-4dannjjm 756 4 this this DT cord-023095-4dannjjm 756 5 study study NN cord-023095-4dannjjm 756 6 is be VBZ cord-023095-4dannjjm 756 7 to to TO cord-023095-4dannjjm 756 8 determine determine VB cord-023095-4dannjjm 756 9 the the DT cord-023095-4dannjjm 756 10 effect effect NN cord-023095-4dannjjm 756 11 of of IN cord-023095-4dannjjm 756 12 Sildenafil Sildenafil NNP cord-023095-4dannjjm 756 13 for for IN cord-023095-4dannjjm 756 14 dogs dog NNS cord-023095-4dannjjm 756 15 with with IN cord-023095-4dannjjm 756 16 Eisenmeger Eisenmeger NNP cord-023095-4dannjjm 756 17 's 's POS cord-023095-4dannjjm 756 18 syndrome syndrome NN cord-023095-4dannjjm 756 19 and and CC cord-023095-4dannjjm 756 20 secondary secondary JJ cord-023095-4dannjjm 756 21 erythrocytosis erythrocytosis NN cord-023095-4dannjjm 756 22 . . . cord-023095-4dannjjm 757 1 This this DT cord-023095-4dannjjm 757 2 was be VBD cord-023095-4dannjjm 757 3 a a DT cord-023095-4dannjjm 757 4 prospective prospective JJ cord-023095-4dannjjm 757 5 , , , cord-023095-4dannjjm 757 6 single single JJ cord-023095-4dannjjm 757 7 arm arm NN cord-023095-4dannjjm 757 8 , , , cord-023095-4dannjjm 757 9 open open JJ cord-023095-4dannjjm 757 10 - - HYPH cord-023095-4dannjjm 757 11 label label NN cord-023095-4dannjjm 757 12 study study NN cord-023095-4dannjjm 757 13 . . . cord-023095-4dannjjm 758 1 Five five CD cord-023095-4dannjjm 758 2 clinical clinical JJ cord-023095-4dannjjm 758 3 dogs dog NNS cord-023095-4dannjjm 758 4 with with IN cord-023095-4dannjjm 758 5 ES es NN cord-023095-4dannjjm 758 6 and and CC cord-023095-4dannjjm 758 7 secondary secondary JJ cord-023095-4dannjjm 758 8 erythrocytosis erythrocytosis NN cord-023095-4dannjjm 758 9 were be VBD cord-023095-4dannjjm 758 10 included include VBN cord-023095-4dannjjm 758 11 . . . cord-023095-4dannjjm 759 1 New New NNP cord-023095-4dannjjm 759 2 York York NNP cord-023095-4dannjjm 759 3 Heart Heart NNP cord-023095-4dannjjm 759 4 Association Association NNP cord-023095-4dannjjm 759 5 ( ( -LRB- cord-023095-4dannjjm 759 6 NYHA NYHA NNP cord-023095-4dannjjm 759 7 ) ) -RRB- cord-023095-4dannjjm 759 8 functional functional JJ cord-023095-4dannjjm 759 9 class class NN cord-023095-4dannjjm 759 10 , , , cord-023095-4dannjjm 759 11 PCV pcv NN cord-023095-4dannjjm 759 12 , , , cord-023095-4dannjjm 759 13 and and CC cord-023095-4dannjjm 759 14 pulmonary pulmonary JJ cord-023095-4dannjjm 759 15 artery artery NN cord-023095-4dannjjm 759 16 acceleration acceleration NN cord-023095-4dannjjm 759 17 time time NN cord-023095-4dannjjm 759 18 to to IN cord-023095-4dannjjm 759 19 ejection ejection NN cord-023095-4dannjjm 759 20 time time NN cord-023095-4dannjjm 759 21 ratio ratio NN cord-023095-4dannjjm 759 22 ( ( -LRB- cord-023095-4dannjjm 759 23 PA PA NNP cord-023095-4dannjjm 759 24 AT AT NNP cord-023095-4dannjjm 759 25 : : : cord-023095-4dannjjm 759 26 ET ET NNP cord-023095-4dannjjm 759 27 ) ) -RRB- cord-023095-4dannjjm 759 28 were be VBD cord-023095-4dannjjm 759 29 evaluated evaluate VBN cord-023095-4dannjjm 759 30 before before IN cord-023095-4dannjjm 759 31 and and CC cord-023095-4dannjjm 759 32 after after IN cord-023095-4dannjjm 759 33 sildenafil sildenafil NNP cord-023095-4dannjjm 759 34 therapy therapy NNP cord-023095-4dannjjm 759 35 ( ( -LRB- cord-023095-4dannjjm 759 36 0.5 0.5 CD cord-023095-4dannjjm 759 37 mg mg NNP cord-023095-4dannjjm 759 38 / / SYM cord-023095-4dannjjm 759 39 kg kg NNP cord-023095-4dannjjm 759 40 , , , cord-023095-4dannjjm 759 41 bid bid NN cord-023095-4dannjjm 759 42 ) ) -RRB- cord-023095-4dannjjm 759 43 . . . cord-023095-4dannjjm 760 1 NYHA NYHA NNP cord-023095-4dannjjm 760 2 functional functional JJ cord-023095-4dannjjm 760 3 class class NN cord-023095-4dannjjm 760 4 was be VBD cord-023095-4dannjjm 760 5 significantly significantly RB cord-023095-4dannjjm 760 6 improved improve VBN cord-023095-4dannjjm 760 7 after after IN cord-023095-4dannjjm 760 8 1 1 CD cord-023095-4dannjjm 760 9 ( ( -LRB- cord-023095-4dannjjm 760 10 median median JJ cord-023095-4dannjjm 760 11 2 2 CD cord-023095-4dannjjm 760 12 ; ; : cord-023095-4dannjjm 760 13 range range VBP cord-023095-4dannjjm 760 14 1 1 CD cord-023095-4dannjjm 760 15 - - SYM cord-023095-4dannjjm 760 16 2 2 CD cord-023095-4dannjjm 760 17 , , , cord-023095-4dannjjm 760 18 P p NN cord-023095-4dannjjm 760 19 5 5 CD cord-023095-4dannjjm 760 20 0.031 0.031 CD cord-023095-4dannjjm 760 21 ) ) -RRB- cord-023095-4dannjjm 760 22 and and CC cord-023095-4dannjjm 760 23 3 3 CD cord-023095-4dannjjm 760 24 months month NNS cord-023095-4dannjjm 760 25 ( ( -LRB- cord-023095-4dannjjm 760 26 median median JJ cord-023095-4dannjjm 760 27 2 2 CD cord-023095-4dannjjm 760 28 ; ; : cord-023095-4dannjjm 760 29 range range VBP cord-023095-4dannjjm 760 30 1 1 CD cord-023095-4dannjjm 760 31 - - SYM cord-023095-4dannjjm 760 32 2 2 CD cord-023095-4dannjjm 760 33 , , , cord-023095-4dannjjm 760 34 P p NN cord-023095-4dannjjm 760 35 5 5 CD cord-023095-4dannjjm 760 36 0.031 0.031 CD cord-023095-4dannjjm 760 37 ) ) -RRB- cord-023095-4dannjjm 760 38 of of IN cord-023095-4dannjjm 760 39 sildenafil sildenafil NNP cord-023095-4dannjjm 760 40 therapy therapy NN cord-023095-4dannjjm 760 41 , , , cord-023095-4dannjjm 760 42 compared compare VBN cord-023095-4dannjjm 760 43 with with IN cord-023095-4dannjjm 760 44 the the DT cord-023095-4dannjjm 760 45 baseline baseline NN cord-023095-4dannjjm 760 46 ( ( -LRB- cord-023095-4dannjjm 760 47 median median NN cord-023095-4dannjjm 760 48 3 3 CD cord-023095-4dannjjm 760 49 , , , cord-023095-4dannjjm 760 50 range range VBP cord-023095-4dannjjm 760 51 2 2 CD cord-023095-4dannjjm 760 52 - - SYM cord-023095-4dannjjm 760 53 3 3 CD cord-023095-4dannjjm 760 54 ) ) -RRB- cord-023095-4dannjjm 760 55 . . . cord-023095-4dannjjm 761 1 PCV PCV NNP cord-023095-4dannjjm 761 2 was be VBD cord-023095-4dannjjm 761 3 significantly significantly RB cord-023095-4dannjjm 761 4 decreased decrease VBN cord-023095-4dannjjm 761 5 after after IN cord-023095-4dannjjm 761 6 1 1 CD cord-023095-4dannjjm 761 7 month month NN cord-023095-4dannjjm 761 8 ( ( -LRB- cord-023095-4dannjjm 761 9 62.4 62.4 CD cord-023095-4dannjjm 761 10 AE AE NNP cord-023095-4dannjjm 761 11 4.7 4.7 CD cord-023095-4dannjjm 761 12 % % NN cord-023095-4dannjjm 761 13 , , , cord-023095-4dannjjm 761 14 P p NN cord-023095-4dannjjm 761 15 5 5 CD cord-023095-4dannjjm 761 16 0.015 0.015 CD cord-023095-4dannjjm 761 17 ) ) -RRB- cord-023095-4dannjjm 761 18 and and CC cord-023095-4dannjjm 761 19 3 3 CD cord-023095-4dannjjm 761 20 months month NNS cord-023095-4dannjjm 761 21 ( ( -LRB- cord-023095-4dannjjm 761 22 59.9 59.9 CD cord-023095-4dannjjm 761 23 AE AE NNP cord-023095-4dannjjm 761 24 3.6 3.6 CD cord-023095-4dannjjm 761 25 % % NN cord-023095-4dannjjm 761 26 , , , cord-023095-4dannjjm 761 27 P p NN cord-023095-4dannjjm 761 28 5 5 CD cord-023095-4dannjjm 761 29 0.01 0.01 CD cord-023095-4dannjjm 761 30 ) ) -RRB- cord-023095-4dannjjm 761 31 of of IN cord-023095-4dannjjm 761 32 therapy therapy NN cord-023095-4dannjjm 761 33 , , , cord-023095-4dannjjm 761 34 compared compare VBN cord-023095-4dannjjm 761 35 with with IN cord-023095-4dannjjm 761 36 the the DT cord-023095-4dannjjm 761 37 baseline baseline NN cord-023095-4dannjjm 761 38 ( ( -LRB- cord-023095-4dannjjm 761 39 68.0 68.0 CD cord-023095-4dannjjm 761 40 AE AE NNP cord-023095-4dannjjm 761 41 5.6 5.6 CD cord-023095-4dannjjm 761 42 % % NN cord-023095-4dannjjm 761 43 ) ) -RRB- cord-023095-4dannjjm 761 44 . . . cord-023095-4dannjjm 762 1 AT at IN cord-023095-4dannjjm 762 2 : : : cord-023095-4dannjjm 762 3 ET ET NNP cord-023095-4dannjjm 762 4 was be VBD cord-023095-4dannjjm 762 5 significantly significantly RB cord-023095-4dannjjm 762 6 increased increase VBN cord-023095-4dannjjm 762 7 after after IN cord-023095-4dannjjm 762 8 1 1 CD cord-023095-4dannjjm 762 9 month month NN cord-023095-4dannjjm 762 10 of of IN cord-023095-4dannjjm 762 11 therapy therapy NN cord-023095-4dannjjm 762 12 ( ( -LRB- cord-023095-4dannjjm 762 13 0.39 0.39 CD cord-023095-4dannjjm 762 14 AE AE NNP cord-023095-4dannjjm 762 15 0.06 0.06 CD cord-023095-4dannjjm 762 16 , , , cord-023095-4dannjjm 762 17 P p NN cord-023095-4dannjjm 762 18 5 5 CD cord-023095-4dannjjm 762 19 0.013 0.013 CD cord-023095-4dannjjm 762 20 ) ) -RRB- cord-023095-4dannjjm 762 21 from from IN cord-023095-4dannjjm 762 22 the the DT cord-023095-4dannjjm 762 23 baseline baseline NN cord-023095-4dannjjm 762 24 ( ( -LRB- cord-023095-4dannjjm 762 25 0.28 0.28 CD cord-023095-4dannjjm 762 26 AE AE NNP cord-023095-4dannjjm 762 27 0.04 0.04 CD cord-023095-4dannjjm 762 28 ) ) -RRB- cord-023095-4dannjjm 762 29 . . . cord-023095-4dannjjm 763 1 Sildenafil Sildenafil NNP cord-023095-4dannjjm 763 2 resolved resolve VBD cord-023095-4dannjjm 763 3 the the DT cord-023095-4dannjjm 763 4 clinical clinical JJ cord-023095-4dannjjm 763 5 signs sign NNS cord-023095-4dannjjm 763 6 and and CC cord-023095-4dannjjm 763 7 secondary secondary JJ cord-023095-4dannjjm 763 8 erythrocytosis erythrocytosis NN cord-023095-4dannjjm 763 9 in in IN cord-023095-4dannjjm 763 10 dogs dog NNS cord-023095-4dannjjm 763 11 with with IN cord-023095-4dannjjm 763 12 ES ES NNP cord-023095-4dannjjm 763 13 . . . cord-023095-4dannjjm 764 1 Sildenafil sildenafil NN cord-023095-4dannjjm 764 2 therapy therapy NN cord-023095-4dannjjm 764 3 could could MD cord-023095-4dannjjm 764 4 be be VB cord-023095-4dannjjm 764 5 the the DT cord-023095-4dannjjm 764 6 treatment treatment NN cord-023095-4dannjjm 764 7 of of IN cord-023095-4dannjjm 764 8 choice choice NN cord-023095-4dannjjm 764 9 for for IN cord-023095-4dannjjm 764 10 dogs dog NNS cord-023095-4dannjjm 764 11 with with IN cord-023095-4dannjjm 764 12 ES ES NNP cord-023095-4dannjjm 764 13 . . . cord-023095-4dannjjm 765 1 Sepsis sepsis NN cord-023095-4dannjjm 765 2 is be VBZ cord-023095-4dannjjm 765 3 the the DT cord-023095-4dannjjm 765 4 number number NN cord-023095-4dannjjm 765 5 one one CD cord-023095-4dannjjm 765 6 cause cause NN cord-023095-4dannjjm 765 7 of of IN cord-023095-4dannjjm 765 8 mortality mortality NN cord-023095-4dannjjm 765 9 in in IN cord-023095-4dannjjm 765 10 neonatal neonatal JJ cord-023095-4dannjjm 765 11 foals foal NNS cord-023095-4dannjjm 765 12 . . . cord-023095-4dannjjm 766 1 The the DT cord-023095-4dannjjm 766 2 role role NN cord-023095-4dannjjm 766 3 of of IN cord-023095-4dannjjm 766 4 the the DT cord-023095-4dannjjm 766 5 RAAS raa NNS cord-023095-4dannjjm 766 6 and and CC cord-023095-4dannjjm 766 7 HPAA HPAA NNP cord-023095-4dannjjm 766 8 in in IN cord-023095-4dannjjm 766 9 systemic systemic JJ cord-023095-4dannjjm 766 10 inflammation inflammation NN cord-023095-4dannjjm 766 11 and and CC cord-023095-4dannjjm 766 12 response response NN cord-023095-4dannjjm 766 13 to to IN cord-023095-4dannjjm 766 14 stress stress NN cord-023095-4dannjjm 766 15 is be VBZ cord-023095-4dannjjm 766 16 well well RB cord-023095-4dannjjm 766 17 documented document VBN cord-023095-4dannjjm 766 18 in in IN cord-023095-4dannjjm 766 19 critically critically RB cord-023095-4dannjjm 766 20 ill ill JJ cord-023095-4dannjjm 766 21 human human JJ cord-023095-4dannjjm 766 22 neonates neonate NNS cord-023095-4dannjjm 766 23 , , , cord-023095-4dannjjm 766 24 but but CC cord-023095-4dannjjm 766 25 limited limited JJ cord-023095-4dannjjm 766 26 information information NN cord-023095-4dannjjm 766 27 exists exist VBZ cord-023095-4dannjjm 766 28 in in IN cord-023095-4dannjjm 766 29 foals foal NNS cord-023095-4dannjjm 766 30 . . . cord-023095-4dannjjm 767 1 We -PRON- PRP cord-023095-4dannjjm 767 2 hypothesized hypothesize VBD cord-023095-4dannjjm 767 3 that that IN cord-023095-4dannjjm 767 4 in in IN cord-023095-4dannjjm 767 5 septic septic JJ cord-023095-4dannjjm 767 6 foals foal NNS cord-023095-4dannjjm 767 7 the the DT cord-023095-4dannjjm 767 8 RAAS raa NNS cord-023095-4dannjjm 767 9 and and CC cord-023095-4dannjjm 767 10 HPAA HPAA NNP cord-023095-4dannjjm 767 11 will will MD cord-023095-4dannjjm 767 12 be be VB cord-023095-4dannjjm 767 13 activated activate VBN cord-023095-4dannjjm 767 14 by by IN cord-023095-4dannjjm 767 15 systemic systemic JJ cord-023095-4dannjjm 767 16 inflammation inflammation NN cord-023095-4dannjjm 767 17 and and CC cord-023095-4dannjjm 767 18 hypoperfusion hypoperfusion NN cord-023095-4dannjjm 767 19 and and CC cord-023095-4dannjjm 767 20 the the DT cord-023095-4dannjjm 767 21 degree degree NN cord-023095-4dannjjm 767 22 of of IN cord-023095-4dannjjm 767 23 activation activation NN cord-023095-4dannjjm 767 24 will will MD cord-023095-4dannjjm 767 25 be be VB cord-023095-4dannjjm 767 26 associated associate VBN cord-023095-4dannjjm 767 27 with with IN cord-023095-4dannjjm 767 28 severity severity NN cord-023095-4dannjjm 767 29 of of IN cord-023095-4dannjjm 767 30 sepsis sepsis NN cord-023095-4dannjjm 767 31 and and CC cord-023095-4dannjjm 767 32 mortality mortality NN cord-023095-4dannjjm 767 33 . . . cord-023095-4dannjjm 768 1 Blood blood NN cord-023095-4dannjjm 768 2 samples sample NNS cord-023095-4dannjjm 768 3 were be VBD cord-023095-4dannjjm 768 4 collected collect VBN cord-023095-4dannjjm 768 5 on on IN cord-023095-4dannjjm 768 6 admission admission NN cord-023095-4dannjjm 768 7 from from IN cord-023095-4dannjjm 768 8 60 60 CD cord-023095-4dannjjm 768 9 septic septic NN cord-023095-4dannjjm 768 10 ( ( -LRB- cord-023095-4dannjjm 768 11 sepsis sepsis NN cord-023095-4dannjjm 768 12 score score NN cord-023095-4dannjjm 768 13 4 4 CD cord-023095-4dannjjm 768 14 12 12 CD cord-023095-4dannjjm 768 15 ) ) -RRB- cord-023095-4dannjjm 768 16 , , , cord-023095-4dannjjm 768 17 102 102 CD cord-023095-4dannjjm 768 18 sick sick JJ cord-023095-4dannjjm 768 19 non non JJ cord-023095-4dannjjm 768 20 - - JJ cord-023095-4dannjjm 768 21 septic septic JJ cord-023095-4dannjjm 768 22 ( ( -LRB- cord-023095-4dannjjm 768 23 SNS SNS NNP cord-023095-4dannjjm 768 24 ) ) -RRB- cord-023095-4dannjjm 768 25 , , , cord-023095-4dannjjm 768 26 and and CC cord-023095-4dannjjm 768 27 18 18 CD cord-023095-4dannjjm 768 28 healthy healthy JJ cord-023095-4dannjjm 768 29 foals foal NNS cord-023095-4dannjjm 768 30 of of IN cord-023095-4dannjjm 768 31 o o NN cord-023095-4dannjjm 768 32 7 7 CD cord-023095-4dannjjm 768 33 days day NNS cord-023095-4dannjjm 768 34 of of IN cord-023095-4dannjjm 768 35 age age NN cord-023095-4dannjjm 768 36 . . . cord-023095-4dannjjm 769 1 Blood blood NN cord-023095-4dannjjm 769 2 concentrations concentration NNS cord-023095-4dannjjm 769 3 of of IN cord-023095-4dannjjm 769 4 corticotropin corticotropin NNP cord-023095-4dannjjm 769 5 - - HYPH cord-023095-4dannjjm 769 6 releasing release VBG cord-023095-4dannjjm 769 7 hormone hormone NN cord-023095-4dannjjm 769 8 ( ( -LRB- cord-023095-4dannjjm 769 9 CRH CRH NNP cord-023095-4dannjjm 769 10 ) ) -RRB- cord-023095-4dannjjm 769 11 , , , cord-023095-4dannjjm 769 12 adrenocorticotropin adrenocorticotropin NNP cord-023095-4dannjjm 769 13 ( ( -LRB- cord-023095-4dannjjm 769 14 ACTH ACTH NNP cord-023095-4dannjjm 769 15 ) ) -RRB- cord-023095-4dannjjm 770 1 , , , cord-023095-4dannjjm 770 2 cortisol cortisol NN cord-023095-4dannjjm 770 3 , , , cord-023095-4dannjjm 770 4 aldosterone aldosterone NN cord-023095-4dannjjm 770 5 , , , cord-023095-4dannjjm 770 6 angiotensin angiotensin NN cord-023095-4dannjjm 770 7 - - HYPH cord-023095-4dannjjm 770 8 II II NNP cord-023095-4dannjjm 770 9 ( ( -LRB- cord-023095-4dannjjm 770 10 ANG ANG NNP cord-023095-4dannjjm 770 11 - - HYPH cord-023095-4dannjjm 770 12 II II NNP cord-023095-4dannjjm 770 13 ) ) -RRB- cord-023095-4dannjjm 770 14 , , , cord-023095-4dannjjm 770 15 arginine arginine NN cord-023095-4dannjjm 770 16 vasopressin vasopressin FW cord-023095-4dannjjm 770 17 ( ( -LRB- cord-023095-4dannjjm 770 18 AVP AVP NNP cord-023095-4dannjjm 770 19 ) ) -RRB- cord-023095-4dannjjm 770 20 and and CC cord-023095-4dannjjm 770 21 plasma plasma NN cord-023095-4dannjjm 770 22 renin renin NN cord-023095-4dannjjm 770 23 activity activity NN cord-023095-4dannjjm 770 24 were be VBD cord-023095-4dannjjm 770 25 determined determine VBN cord-023095-4dannjjm 770 26 by by IN cord-023095-4dannjjm 770 27 radioimmunoassays radioimmunoassay NNS cord-023095-4dannjjm 770 28 . . . cord-023095-4dannjjm 771 1 ACTH ACTH NNP cord-023095-4dannjjm 771 2 , , , cord-023095-4dannjjm 771 3 cortisol cortisol NN cord-023095-4dannjjm 771 4 , , , cord-023095-4dannjjm 771 5 aldosterone aldosterone NN cord-023095-4dannjjm 771 6 , , , cord-023095-4dannjjm 771 7 ANG ANG NNP cord-023095-4dannjjm 771 8 - - HYPH cord-023095-4dannjjm 771 9 II II NNP cord-023095-4dannjjm 771 10 and and CC cord-023095-4dannjjm 771 11 AVP AVP NNP cord-023095-4dannjjm 771 12 concentrations concentration NNS cord-023095-4dannjjm 771 13 were be VBD cord-023095-4dannjjm 771 14 higher high JJR cord-023095-4dannjjm 771 15 while while IN cord-023095-4dannjjm 771 16 CRH CRH NNP cord-023095-4dannjjm 771 17 was be VBD cord-023095-4dannjjm 771 18 lower low JJR cord-023095-4dannjjm 771 19 in in IN cord-023095-4dannjjm 771 20 septic septic NN cord-023095-4dannjjm 771 21 and and CC cord-023095-4dannjjm 771 22 SNS SNS NNP cord-023095-4dannjjm 771 23 foals foal NNS cord-023095-4dannjjm 771 24 compared compare VBN cord-023095-4dannjjm 771 25 to to IN cord-023095-4dannjjm 771 26 healthy healthy JJ cord-023095-4dannjjm 771 27 foals foal NNS cord-023095-4dannjjm 771 28 ( ( -LRB- cord-023095-4dannjjm 771 29 P p NN cord-023095-4dannjjm 771 30 o o NN cord-023095-4dannjjm 771 31 0.05 0.05 CD cord-023095-4dannjjm 771 32 ) ) -RRB- cord-023095-4dannjjm 771 33 . . . cord-023095-4dannjjm 772 1 Septic septic JJ cord-023095-4dannjjm 772 2 non non JJ cord-023095-4dannjjm 772 3 - - JJ cord-023095-4dannjjm 772 4 survivor survivor JJ cord-023095-4dannjjm 772 5 foals foal NNS cord-023095-4dannjjm 772 6 had have VBD cord-023095-4dannjjm 772 7 higher high JJR cord-023095-4dannjjm 772 8 concentrations concentration NNS cord-023095-4dannjjm 772 9 of of IN cord-023095-4dannjjm 772 10 aldosterone aldosterone NN cord-023095-4dannjjm 772 11 , , , cord-023095-4dannjjm 772 12 cortisol cortisol NN cord-023095-4dannjjm 772 13 , , , cord-023095-4dannjjm 772 14 ACTH ACTH NNP cord-023095-4dannjjm 772 15 and and CC cord-023095-4dannjjm 772 16 AVP AVP NNP cord-023095-4dannjjm 772 17 and and CC cord-023095-4dannjjm 772 18 lower low JJR cord-023095-4dannjjm 772 19 concentrations concentration NNS cord-023095-4dannjjm 772 20 of of IN cord-023095-4dannjjm 772 21 ANG ANG NNP cord-023095-4dannjjm 772 22 - - HYPH cord-023095-4dannjjm 772 23 II II NNP cord-023095-4dannjjm 772 24 and and CC cord-023095-4dannjjm 772 25 CRH CRH NNP cord-023095-4dannjjm 772 26 than than IN cord-023095-4dannjjm 772 27 survivors survivor NNS cord-023095-4dannjjm 772 28 . . . cord-023095-4dannjjm 773 1 AVP AVP NNP cord-023095-4dannjjm 773 2 was be VBD cord-023095-4dannjjm 773 3 associated associate VBN cord-023095-4dannjjm 773 4 with with IN cord-023095-4dannjjm 773 5 ANG ANG NNP cord-023095-4dannjjm 773 6 - - HYPH cord-023095-4dannjjm 773 7 II II NNP cord-023095-4dannjjm 773 8 in in IN cord-023095-4dannjjm 773 9 septic septic NN cord-023095-4dannjjm 773 10 , , , cord-023095-4dannjjm 773 11 and and CC cord-023095-4dannjjm 773 12 with with IN cord-023095-4dannjjm 773 13 ACTH ACTH NNP cord-023095-4dannjjm 773 14 in in IN cord-023095-4dannjjm 773 15 septic septic NN cord-023095-4dannjjm 773 16 and and CC cord-023095-4dannjjm 773 17 SNS SNS NNP cord-023095-4dannjjm 773 18 foals foal NNS cord-023095-4dannjjm 773 19 ( ( -LRB- cord-023095-4dannjjm 773 20 P p NN cord-023095-4dannjjm 773 21 o o NN cord-023095-4dannjjm 773 22 0.05 0.05 CD cord-023095-4dannjjm 773 23 ) ) -RRB- cord-023095-4dannjjm 773 24 . . . cord-023095-4dannjjm 774 1 There there EX cord-023095-4dannjjm 774 2 was be VBD cord-023095-4dannjjm 774 3 no no DT cord-023095-4dannjjm 774 4 difference difference NN cord-023095-4dannjjm 774 5 in in IN cord-023095-4dannjjm 774 6 renin renin NN cord-023095-4dannjjm 774 7 activity activity NN cord-023095-4dannjjm 774 8 and and CC cord-023095-4dannjjm 774 9 ANG ANG NNP cord-023095-4dannjjm 774 10 - - HYPH cord-023095-4dannjjm 774 11 II II NNP cord-023095-4dannjjm 774 12 concentrations concentration NNS cord-023095-4dannjjm 774 13 among among IN cord-023095-4dannjjm 774 14 foal foal NN cord-023095-4dannjjm 774 15 groups group NNS cord-023095-4dannjjm 774 16 . . . cord-023095-4dannjjm 775 1 Septic septic JJ cord-023095-4dannjjm 775 2 foals foal NNS cord-023095-4dannjjm 775 3 had have VBD cord-023095-4dannjjm 775 4 a a DT cord-023095-4dannjjm 775 5 higher high JJR cord-023095-4dannjjm 775 6 ACTH ACTH NNP cord-023095-4dannjjm 775 7 : : : cord-023095-4dannjjm 775 8 aldosterone aldosterone NN cord-023095-4dannjjm 775 9 ratio ratio NN cord-023095-4dannjjm 775 10 than than IN cord-023095-4dannjjm 775 11 healthy healthy JJ cord-023095-4dannjjm 775 12 foals foal NNS cord-023095-4dannjjm 775 13 ( ( -LRB- cord-023095-4dannjjm 775 14 P p NN cord-023095-4dannjjm 775 15 o o NN cord-023095-4dannjjm 775 16 0.001 0.001 CD cord-023095-4dannjjm 775 17 ) ) -RRB- cord-023095-4dannjjm 775 18 . . . cord-023095-4dannjjm 776 1 This this DT cord-023095-4dannjjm 776 2 study study NN cord-023095-4dannjjm 776 3 shows show VBZ cord-023095-4dannjjm 776 4 that that IN cord-023095-4dannjjm 776 5 in in IN cord-023095-4dannjjm 776 6 response response NN cord-023095-4dannjjm 776 7 to to IN cord-023095-4dannjjm 776 8 sepsis sepsis NN cord-023095-4dannjjm 776 9 there there EX cord-023095-4dannjjm 776 10 is be VBZ cord-023095-4dannjjm 776 11 RAAS RAAS NNP cord-023095-4dannjjm 776 12 and and CC cord-023095-4dannjjm 776 13 HPAA HPAA NNP cord-023095-4dannjjm 776 14 activation activation NN cord-023095-4dannjjm 776 15 in in IN cord-023095-4dannjjm 776 16 critically critically RB cord-023095-4dannjjm 776 17 ill ill JJ cord-023095-4dannjjm 776 18 foals foal NNS cord-023095-4dannjjm 776 19 . . . cord-023095-4dannjjm 777 1 We -PRON- PRP cord-023095-4dannjjm 777 2 propose propose VBP cord-023095-4dannjjm 777 3 that that IN cord-023095-4dannjjm 777 4 in in IN cord-023095-4dannjjm 777 5 sick sick JJ cord-023095-4dannjjm 777 6 foals foal NNS cord-023095-4dannjjm 777 7 AVP AVP NNP cord-023095-4dannjjm 777 8 is be VBZ cord-023095-4dannjjm 777 9 more more RBR cord-023095-4dannjjm 777 10 important important JJ cord-023095-4dannjjm 777 11 than than IN cord-023095-4dannjjm 777 12 CRH CRH NNP cord-023095-4dannjjm 777 13 in in IN cord-023095-4dannjjm 777 14 regulating regulate VBG cord-023095-4dannjjm 777 15 ACTH ACTH NNP cord-023095-4dannjjm 777 16 secretion secretion NN cord-023095-4dannjjm 777 17 . . . cord-023095-4dannjjm 778 1 The the DT cord-023095-4dannjjm 778 2 increased increase VBN cord-023095-4dannjjm 778 3 ACTH ACTH NNP cord-023095-4dannjjm 778 4 : : : cord-023095-4dannjjm 778 5 aldosterone aldosterone NN cord-023095-4dannjjm 778 6 ratio ratio NN cord-023095-4dannjjm 778 7 further further RB cord-023095-4dannjjm 778 8 supports support VBZ cord-023095-4dannjjm 778 9 relative relative JJ cord-023095-4dannjjm 778 10 adrenal adrenal JJ cord-023095-4dannjjm 778 11 insufficiency insufficiency NN cord-023095-4dannjjm 778 12 in in IN cord-023095-4dannjjm 778 13 septic septic JJ cord-023095-4dannjjm 778 14 foals foal NNS cord-023095-4dannjjm 778 15 . . . cord-023095-4dannjjm 779 1 This this DT cord-023095-4dannjjm 779 2 prospective prospective NN cord-023095-4dannjjm 779 3 , , , cord-023095-4dannjjm 779 4 cohort cohort NN cord-023095-4dannjjm 779 5 study study NN cord-023095-4dannjjm 779 6 aimed aim VBN cord-023095-4dannjjm 779 7 to to TO cord-023095-4dannjjm 779 8 characterize characterize VB cord-023095-4dannjjm 779 9 alterations alteration NNS cord-023095-4dannjjm 779 10 in in IN cord-023095-4dannjjm 779 11 coagulation coagulation NN cord-023095-4dannjjm 779 12 and and CC cord-023095-4dannjjm 779 13 blood blood NN cord-023095-4dannjjm 779 14 - - HYPH cord-023095-4dannjjm 779 15 derived derive VBN cord-023095-4dannjjm 779 16 inflammatory inflammatory JJ cord-023095-4dannjjm 779 17 biomarkers biomarker NNS cord-023095-4dannjjm 779 18 in in IN cord-023095-4dannjjm 779 19 adult adult NN cord-023095-4dannjjm 779 20 horses horse NNS cord-023095-4dannjjm 779 21 that that WDT cord-023095-4dannjjm 779 22 developed develop VBD cord-023095-4dannjjm 779 23 diarrhea diarrhea NN cord-023095-4dannjjm 779 24 during during IN cord-023095-4dannjjm 779 25 hospitalization hospitalization NN cord-023095-4dannjjm 779 26 . . . cord-023095-4dannjjm 780 1 Physical physical JJ cord-023095-4dannjjm 780 2 and and CC cord-023095-4dannjjm 780 3 hematological hematological JJ cord-023095-4dannjjm 780 4 parameters parameter NNS cord-023095-4dannjjm 780 5 were be VBD cord-023095-4dannjjm 780 6 evaluated evaluate VBN cord-023095-4dannjjm 780 7 at at IN cord-023095-4dannjjm 780 8 times time NNS cord-023095-4dannjjm 780 9 0 0 NFP cord-023095-4dannjjm 780 10 ( ( -LRB- cord-023095-4dannjjm 780 11 onset onset NN cord-023095-4dannjjm 780 12 of of IN cord-023095-4dannjjm 780 13 diarrhea diarrhea NN cord-023095-4dannjjm 780 14 ) ) -RRB- cord-023095-4dannjjm 780 15 , , , cord-023095-4dannjjm 780 16 6 6 CD cord-023095-4dannjjm 780 17 , , , cord-023095-4dannjjm 780 18 12 12 CD cord-023095-4dannjjm 780 19 , , , cord-023095-4dannjjm 780 20 24 24 CD cord-023095-4dannjjm 780 21 and and CC cord-023095-4dannjjm 780 22 48h 48h NNS cord-023095-4dannjjm 780 23 , , , cord-023095-4dannjjm 780 24 then then RB cord-023095-4dannjjm 780 25 every every DT cord-023095-4dannjjm 780 26 48 48 CD cord-023095-4dannjjm 780 27 h h NN cord-023095-4dannjjm 780 28 until until IN cord-023095-4dannjjm 780 29 resolution resolution NN cord-023095-4dannjjm 780 30 of of IN cord-023095-4dannjjm 780 31 diarrhea diarrhea NN cord-023095-4dannjjm 780 32 or or CC cord-023095-4dannjjm 780 33 death death NN cord-023095-4dannjjm 780 34 . . . cord-023095-4dannjjm 781 1 Each each DT cord-023095-4dannjjm 781 2 hematological hematological JJ cord-023095-4dannjjm 781 3 analysis analysis NN cord-023095-4dannjjm 781 4 included include VBD cord-023095-4dannjjm 781 5 a a DT cord-023095-4dannjjm 781 6 complete complete JJ cord-023095-4dannjjm 781 7 blood blood NN cord-023095-4dannjjm 781 8 count count NN cord-023095-4dannjjm 781 9 ( ( -LRB- cord-023095-4dannjjm 781 10 CBC CBC NNP cord-023095-4dannjjm 781 11 ) ) -RRB- cord-023095-4dannjjm 781 12 , , , cord-023095-4dannjjm 781 13 thromboelastography thromboelastography NNP cord-023095-4dannjjm 781 14 ( ( -LRB- cord-023095-4dannjjm 781 15 TEG TEG NNP cord-023095-4dannjjm 781 16 ) ) -RRB- cord-023095-4dannjjm 781 17 , , , cord-023095-4dannjjm 781 18 partial partial JJ cord-023095-4dannjjm 781 19 - - HYPH cord-023095-4dannjjm 781 20 thromboplastin thromboplastin NN cord-023095-4dannjjm 781 21 - - HYPH cord-023095-4dannjjm 781 22 time time NN cord-023095-4dannjjm 781 23 ( ( -LRB- cord-023095-4dannjjm 781 24 PTT PTT NNP cord-023095-4dannjjm 781 25 ) ) -RRB- cord-023095-4dannjjm 781 26 , , , cord-023095-4dannjjm 781 27 prothrombin prothrombin NN cord-023095-4dannjjm 781 28 - - HYPH cord-023095-4dannjjm 781 29 time time NN cord-023095-4dannjjm 781 30 ( ( -LRB- cord-023095-4dannjjm 781 31 PT PT NNP cord-023095-4dannjjm 781 32 ) ) -RRB- cord-023095-4dannjjm 781 33 , , , cord-023095-4dannjjm 781 34 plasma plasma NN cord-023095-4dannjjm 781 35 concentrations concentration NNS cord-023095-4dannjjm 781 36 of of IN cord-023095-4dannjjm 781 37 lactate lactate NN cord-023095-4dannjjm 781 38 , , , cord-023095-4dannjjm 781 39 tumor tumor NN cord-023095-4dannjjm 781 40 necrosis necrosis NN cord-023095-4dannjjm 781 41 factor factor NN cord-023095-4dannjjm 781 42 alpha alpha NN cord-023095-4dannjjm 781 43 ( ( -LRB- cord-023095-4dannjjm 781 44 TNF TNF NNP cord-023095-4dannjjm 781 45 - - HYPH cord-023095-4dannjjm 781 46 a a NNP cord-023095-4dannjjm 781 47 ) ) -RRB- cord-023095-4dannjjm 781 48 , , , cord-023095-4dannjjm 781 49 interleukin interleukin FW cord-023095-4dannjjm 781 50 ( ( -LRB- cord-023095-4dannjjm 781 51 IL)-1 IL)-1 '' cord-023095-4dannjjm 781 52 , , , cord-023095-4dannjjm 781 53 IL-6 IL-6 NNP cord-023095-4dannjjm 781 54 , , , cord-023095-4dannjjm 781 55 IL-10 IL-10 NNP cord-023095-4dannjjm 781 56 and and CC cord-023095-4dannjjm 781 57 NT NT NNP cord-023095-4dannjjm 781 58 - - HYPH cord-023095-4dannjjm 781 59 proC proc JJ cord-023095-4dannjjm 781 60 - - HYPH cord-023095-4dannjjm 781 61 type type NN cord-023095-4dannjjm 781 62 - - HYPH cord-023095-4dannjjm 781 63 natriuretic natriuretic NN cord-023095-4dannjjm 781 64 peptide peptide NN cord-023095-4dannjjm 781 65 ( ( -LRB- cord-023095-4dannjjm 781 66 pCNP pCNP NNP cord-023095-4dannjjm 781 67 ) ) -RRB- cord-023095-4dannjjm 781 68 . . . cord-023095-4dannjjm 782 1 Horses horse NNS cord-023095-4dannjjm 782 2 were be VBD cord-023095-4dannjjm 782 3 categorized categorize VBN cord-023095-4dannjjm 782 4 into into IN cord-023095-4dannjjm 782 5 three three CD cord-023095-4dannjjm 782 6 groups group NNS cord-023095-4dannjjm 782 7 based base VBN cord-023095-4dannjjm 782 8 on on IN cord-023095-4dannjjm 782 9 the the DT cord-023095-4dannjjm 782 10 duration duration NN cord-023095-4dannjjm 782 11 of of IN cord-023095-4dannjjm 782 12 diarrhea diarrhea NN cord-023095-4dannjjm 782 13 and and CC cord-023095-4dannjjm 782 14 evidence evidence NN cord-023095-4dannjjm 782 15 of of IN cord-023095-4dannjjm 782 16 systemic systemic JJ cord-023095-4dannjjm 782 17 inflammation inflammation NN cord-023095-4dannjjm 782 18 . . . cord-023095-4dannjjm 783 1 Group group NN cord-023095-4dannjjm 783 2 0 0 CD cord-023095-4dannjjm 783 3 : : : cord-023095-4dannjjm 783 4 Diarrhea diarrhea NN cord-023095-4dannjjm 783 5 o o NN cord-023095-4dannjjm 783 6 6 6 CD cord-023095-4dannjjm 783 7 h h NN cord-023095-4dannjjm 783 8 without without IN cord-023095-4dannjjm 783 9 systemic systemic JJ cord-023095-4dannjjm 783 10 inflammation inflammation NN cord-023095-4dannjjm 783 11 ( ( -LRB- cord-023095-4dannjjm 783 12 SI SI NNP cord-023095-4dannjjm 783 13 ) ) -RRB- cord-023095-4dannjjm 783 14 ; ; : cord-023095-4dannjjm 783 15 Group group NN cord-023095-4dannjjm 783 16 1 1 CD cord-023095-4dannjjm 783 17 -Diarrhea -Diarrhea NNP cord-023095-4dannjjm 783 18 ! ! . cord-023095-4dannjjm 784 1 6 6 CD cord-023095-4dannjjm 784 2 h h NN cord-023095-4dannjjm 784 3 without without IN cord-023095-4dannjjm 784 4 SI SI NNP cord-023095-4dannjjm 784 5 ; ; : cord-023095-4dannjjm 784 6 Group Group NNP cord-023095-4dannjjm 784 7 2-Diarrhea 2-Diarrhea NNP cord-023095-4dannjjm 784 8 with with IN cord-023095-4dannjjm 784 9 SI SI NNP cord-023095-4dannjjm 784 10 . . . cord-023095-4dannjjm 785 1 Assessment assessment NN cord-023095-4dannjjm 785 2 of of IN cord-023095-4dannjjm 785 3 vital vital JJ cord-023095-4dannjjm 785 4 parameters parameter NNS cord-023095-4dannjjm 785 5 and and CC cord-023095-4dannjjm 785 6 CBC CBC NNP cord-023095-4dannjjm 785 7 established establish VBD cord-023095-4dannjjm 785 8 a a DT cord-023095-4dannjjm 785 9 diagnosis diagnosis NN cord-023095-4dannjjm 785 10 of of IN cord-023095-4dannjjm 785 11 SI SI NNP cord-023095-4dannjjm 785 12 as as IN cord-023095-4dannjjm 785 13 previously previously RB cord-023095-4dannjjm 785 14 described describe VBN cord-023095-4dannjjm 785 15 ( ( -LRB- cord-023095-4dannjjm 785 16 Levy Levy NNP cord-023095-4dannjjm 785 17 , , , cord-023095-4dannjjm 785 18 2003 2003 CD cord-023095-4dannjjm 785 19 ) ) -RRB- cord-023095-4dannjjm 785 20 . . . cord-023095-4dannjjm 786 1 Descriptive descriptive JJ cord-023095-4dannjjm 786 2 and and CC cord-023095-4dannjjm 786 3 univariate univariate JJ cord-023095-4dannjjm 786 4 outcome outcome NN cord-023095-4dannjjm 786 5 analyses analysis NNS cord-023095-4dannjjm 786 6 were be VBD cord-023095-4dannjjm 786 7 based base VBN cord-023095-4dannjjm 786 8 on on IN cord-023095-4dannjjm 786 9 data datum NNS cord-023095-4dannjjm 786 10 normality normality NN cord-023095-4dannjjm 786 11 . . . cord-023095-4dannjjm 787 1 19 19 CD cord-023095-4dannjjm 787 2 horses horse NNS cord-023095-4dannjjm 787 3 were be VBD cord-023095-4dannjjm 787 4 enrolled enrol VBN cord-023095-4dannjjm 787 5 , , , cord-023095-4dannjjm 787 6 of of IN cord-023095-4dannjjm 787 7 which which WDT cord-023095-4dannjjm 787 8 16 16 CD cord-023095-4dannjjm 787 9 ( ( -LRB- cord-023095-4dannjjm 787 10 84.2 84.2 CD cord-023095-4dannjjm 787 11 % % NN cord-023095-4dannjjm 787 12 ) ) -RRB- cord-023095-4dannjjm 787 13 survived survive VBD cord-023095-4dannjjm 787 14 to to TO cord-023095-4dannjjm 787 15 discharge discharge VB cord-023095-4dannjjm 787 16 . . . cord-023095-4dannjjm 788 1 The the DT cord-023095-4dannjjm 788 2 mean mean JJ cord-023095-4dannjjm 788 3 age age NN cord-023095-4dannjjm 788 4 was be VBD cord-023095-4dannjjm 788 5 13.61/-5.3 13.61/-5.3 CD cord-023095-4dannjjm 788 6 years year NNS cord-023095-4dannjjm 788 7 . . . cord-023095-4dannjjm 789 1 Eight eight CD cord-023095-4dannjjm 789 2 horses horse NNS cord-023095-4dannjjm 789 3 ( ( -LRB- cord-023095-4dannjjm 789 4 42.1 42.1 CD cord-023095-4dannjjm 789 5 % % NN cord-023095-4dannjjm 789 6 ) ) -RRB- cord-023095-4dannjjm 789 7 were be VBD cord-023095-4dannjjm 789 8 categorized categorize VBN cord-023095-4dannjjm 789 9 as as IN cord-023095-4dannjjm 789 10 group-0 group-0 NNP cord-023095-4dannjjm 789 11 , , , cord-023095-4dannjjm 789 12 2 2 CD cord-023095-4dannjjm 789 13 ( ( -LRB- cord-023095-4dannjjm 789 14 10.5 10.5 CD cord-023095-4dannjjm 789 15 % % NN cord-023095-4dannjjm 789 16 ) ) -RRB- cord-023095-4dannjjm 789 17 as as IN cord-023095-4dannjjm 789 18 group-1 group-1 NN cord-023095-4dannjjm 789 19 and and CC cord-023095-4dannjjm 789 20 9 9 CD cord-023095-4dannjjm 789 21 ( ( -LRB- cord-023095-4dannjjm 789 22 47.4 47.4 CD cord-023095-4dannjjm 789 23 % % NN cord-023095-4dannjjm 789 24 ) ) -RRB- cord-023095-4dannjjm 789 25 as as IN cord-023095-4dannjjm 789 26 group-2 group-2 NNP cord-023095-4dannjjm 789 27 . . . cord-023095-4dannjjm 790 1 Two two CD cord-023095-4dannjjm 790 2 horses horse NNS cord-023095-4dannjjm 790 3 developed develop VBD cord-023095-4dannjjm 790 4 thrombophlebitis thrombophlebitis NNP cord-023095-4dannjjm 790 5 . . . cord-023095-4dannjjm 791 1 Based base VBN cord-023095-4dannjjm 791 2 on on IN cord-023095-4dannjjm 791 3 the the DT cord-023095-4dannjjm 791 4 results result NNS cord-023095-4dannjjm 791 5 of of IN cord-023095-4dannjjm 791 6 TEG TEG NNP cord-023095-4dannjjm 791 7 , , , cord-023095-4dannjjm 791 8 6/19 6/19 CD cord-023095-4dannjjm 791 9 ( ( -LRB- cord-023095-4dannjjm 791 10 31.6 31.6 CD cord-023095-4dannjjm 791 11 % % NN cord-023095-4dannjjm 791 12 ) ) -RRB- cord-023095-4dannjjm 791 13 were be VBD cord-023095-4dannjjm 791 14 normocoagulable normocoagulable JJ cord-023095-4dannjjm 791 15 , , , cord-023095-4dannjjm 791 16 7/19(36.8 7/19(36.8 CD cord-023095-4dannjjm 791 17 % % NN cord-023095-4dannjjm 791 18 ) ) -RRB- cord-023095-4dannjjm 791 19 were be VBD cord-023095-4dannjjm 791 20 hypocoagulable hypocoagulable NNP cord-023095-4dannjjm 791 21 and and CC cord-023095-4dannjjm 791 22 6/19 6/19 CD cord-023095-4dannjjm 791 23 ( ( -LRB- cord-023095-4dannjjm 791 24 31.6 31.6 CD cord-023095-4dannjjm 791 25 % % NN cord-023095-4dannjjm 791 26 ) ) -RRB- cord-023095-4dannjjm 791 27 were be VBD cord-023095-4dannjjm 791 28 hypercoagulable hypercoagulable JJ cord-023095-4dannjjm 791 29 , , , cord-023095-4dannjjm 791 30 at at IN cord-023095-4dannjjm 791 31 one one CD cord-023095-4dannjjm 791 32 or or CC cord-023095-4dannjjm 791 33 more more JJR cord-023095-4dannjjm 791 34 time time NN cord-023095-4dannjjm 791 35 points point NNS cord-023095-4dannjjm 791 36 . . . cord-023095-4dannjjm 792 1 Of of IN cord-023095-4dannjjm 792 2 these these DT cord-023095-4dannjjm 792 3 , , , cord-023095-4dannjjm 792 4 7/9 7/9 CD cord-023095-4dannjjm 792 5 ( ( -LRB- cord-023095-4dannjjm 792 6 77.8 77.8 CD cord-023095-4dannjjm 792 7 % % NN cord-023095-4dannjjm 792 8 ) ) -RRB- cord-023095-4dannjjm 793 1 group-2 group-2 NNP cord-023095-4dannjjm 793 2 horses horse NNS cord-023095-4dannjjm 793 3 were be VBD cord-023095-4dannjjm 793 4 coagulopathic coagulopathic JJ cord-023095-4dannjjm 793 5 . . . cord-023095-4dannjjm 794 1 Additionally additionally RB cord-023095-4dannjjm 794 2 , , , cord-023095-4dannjjm 794 3 group-2 group-2 NNP cord-023095-4dannjjm 794 4 horses horse NNS cord-023095-4dannjjm 794 5 had have VBD cord-023095-4dannjjm 794 6 a a DT cord-023095-4dannjjm 794 7 significantly significantly RB cord-023095-4dannjjm 794 8 lower low JJR cord-023095-4dannjjm 794 9 MA MA NNP cord-023095-4dannjjm 794 10 than than IN cord-023095-4dannjjm 794 11 group-0 group-0 NNP cord-023095-4dannjjm 794 12 horses horse NNS cord-023095-4dannjjm 794 13 at at IN cord-023095-4dannjjm 794 14 baseline baseline NN cord-023095-4dannjjm 794 15 ( ( -LRB- cord-023095-4dannjjm 794 16 43.6 43.6 CD cord-023095-4dannjjm 794 17 AE AE NNP cord-023095-4dannjjm 794 18 16.7 16.7 CD cord-023095-4dannjjm 794 19 vs. vs. IN cord-023095-4dannjjm 794 20 61.9 61.9 CD cord-023095-4dannjjm 794 21 AE AE NNP cord-023095-4dannjjm 794 22 7.2 7.2 CD cord-023095-4dannjjm 794 23 ) ) -RRB- cord-023095-4dannjjm 794 24 and and CC cord-023095-4dannjjm 794 25 6h 6h NN cord-023095-4dannjjm 794 26 ( ( -LRB- cord-023095-4dannjjm 794 27 45.9 45.9 CD cord-023095-4dannjjm 794 28 AE AE NNP cord-023095-4dannjjm 794 29 15.9 15.9 CD cord-023095-4dannjjm 794 30 vs. vs. IN cord-023095-4dannjjm 794 31 65.5 65.5 CD cord-023095-4dannjjm 794 32 AE AE NNP cord-023095-4dannjjm 794 33 5.8 5.8 CD cord-023095-4dannjjm 794 34 ) ) -RRB- cord-023095-4dannjjm 794 35 . . . cord-023095-4dannjjm 795 1 Biomarker Biomarker NNP cord-023095-4dannjjm 795 2 analyses analysis NNS cord-023095-4dannjjm 795 3 are be VBP cord-023095-4dannjjm 795 4 pending pende VBG cord-023095-4dannjjm 795 5 . . . cord-023095-4dannjjm 796 1 In in IN cord-023095-4dannjjm 796 2 conclusion conclusion NN cord-023095-4dannjjm 796 3 , , , cord-023095-4dannjjm 796 4 SI SI NNP cord-023095-4dannjjm 796 5 was be VBD cord-023095-4dannjjm 796 6 associated associate VBN cord-023095-4dannjjm 796 7 with with IN cord-023095-4dannjjm 796 8 coagulation coagulation NN cord-023095-4dannjjm 796 9 disorders disorder NNS cord-023095-4dannjjm 796 10 in in IN cord-023095-4dannjjm 796 11 horses horse NNS cord-023095-4dannjjm 796 12 with with IN cord-023095-4dannjjm 796 13 hospital hospital NN cord-023095-4dannjjm 796 14 acquired acquire VBN cord-023095-4dannjjm 796 15 diarrhea diarrhea NN cord-023095-4dannjjm 796 16 . . . cord-023095-4dannjjm 797 1 Clostridium clostridium NN cord-023095-4dannjjm 797 2 difficile difficile NN cord-023095-4dannjjm 797 3 and and CC cord-023095-4dannjjm 797 4 Clostridium clostridium NN cord-023095-4dannjjm 797 5 perfringens perfringen NNS cord-023095-4dannjjm 797 6 are be VBP cord-023095-4dannjjm 797 7 commonly commonly RB cord-023095-4dannjjm 797 8 associated associate VBN cord-023095-4dannjjm 797 9 with with IN cord-023095-4dannjjm 797 10 colitis colitis NN cord-023095-4dannjjm 797 11 and and CC cord-023095-4dannjjm 797 12 diarrhea diarrhea NN cord-023095-4dannjjm 797 13 in in IN cord-023095-4dannjjm 797 14 equines equine NNS cord-023095-4dannjjm 797 15 but but CC cord-023095-4dannjjm 797 16 asymptomatic asymptomatic JJ cord-023095-4dannjjm 797 17 carriers carrier NNS cord-023095-4dannjjm 797 18 exist exist VBP cord-023095-4dannjjm 797 19 . . . cord-023095-4dannjjm 798 1 Reported report VBN cord-023095-4dannjjm 798 2 carrier carrier NN cord-023095-4dannjjm 798 3 rates rate NNS cord-023095-4dannjjm 798 4 of of IN cord-023095-4dannjjm 798 5 toxigenic toxigenic JJ cord-023095-4dannjjm 798 6 C. C. NNP cord-023095-4dannjjm 798 7 difficile difficile NNP cord-023095-4dannjjm 798 8 and and CC cord-023095-4dannjjm 798 9 C. C. NNP cord-023095-4dannjjm 798 10 perfringens perfringen VBZ cord-023095-4dannjjm 798 11 strains strain NNS cord-023095-4dannjjm 798 12 in in IN cord-023095-4dannjjm 798 13 feces fece NNS cord-023095-4dannjjm 798 14 range range VBP cord-023095-4dannjjm 798 15 between between IN cord-023095-4dannjjm 798 16 0 0 CD cord-023095-4dannjjm 798 17 - - SYM cord-023095-4dannjjm 798 18 25 25 CD cord-023095-4dannjjm 798 19 % % NN cord-023095-4dannjjm 798 20 and and CC cord-023095-4dannjjm 798 21 0 0 CD cord-023095-4dannjjm 798 22 - - SYM cord-023095-4dannjjm 798 23 30 30 CD cord-023095-4dannjjm 798 24 % % NN cord-023095-4dannjjm 798 25 respectively respectively RB cord-023095-4dannjjm 798 26 . . . cord-023095-4dannjjm 799 1 Toxigenic Toxigenic NNP cord-023095-4dannjjm 799 2 C. C. NNP cord-023095-4dannjjm 799 3 difficile difficile NN cord-023095-4dannjjm 799 4 has have VBZ cord-023095-4dannjjm 799 5 also also RB cord-023095-4dannjjm 799 6 been be VBN cord-023095-4dannjjm 799 7 isolated isolate VBN cord-023095-4dannjjm 799 8 from from IN cord-023095-4dannjjm 799 9 the the DT cord-023095-4dannjjm 799 10 small small JJ cord-023095-4dannjjm 799 11 intestine intestine NN cord-023095-4dannjjm 799 12 of of IN cord-023095-4dannjjm 799 13 diseased diseased JJ cord-023095-4dannjjm 799 14 foals foal NNS cord-023095-4dannjjm 799 15 and and CC cord-023095-4dannjjm 799 16 is be VBZ cord-023095-4dannjjm 799 17 implicated implicate VBN cord-023095-4dannjjm 799 18 as as IN cord-023095-4dannjjm 799 19 etiologic etiologic JJ cord-023095-4dannjjm 799 20 agent agent NN cord-023095-4dannjjm 799 21 of of IN cord-023095-4dannjjm 799 22 duodenitis duodenitis NNP cord-023095-4dannjjm 799 23 / / SYM cord-023095-4dannjjm 799 24 proximal proximal JJ cord-023095-4dannjjm 799 25 jejunitis jejunitis NN cord-023095-4dannjjm 799 26 in in IN cord-023095-4dannjjm 799 27 adult adult NN cord-023095-4dannjjm 799 28 horses horse NNS cord-023095-4dannjjm 800 1 however however RB cord-023095-4dannjjm 800 2 scarce scarce JJ cord-023095-4dannjjm 800 3 information information NN cord-023095-4dannjjm 800 4 is be VBZ cord-023095-4dannjjm 800 5 available available JJ cord-023095-4dannjjm 800 6 on on IN cord-023095-4dannjjm 800 7 prevalence prevalence NN cord-023095-4dannjjm 800 8 in in IN cord-023095-4dannjjm 800 9 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 800 10 compartments compartment NNS cord-023095-4dannjjm 800 11 other other JJ cord-023095-4dannjjm 800 12 than than IN cord-023095-4dannjjm 800 13 feces fece NNS cord-023095-4dannjjm 800 14 in in IN cord-023095-4dannjjm 800 15 healthy healthy JJ cord-023095-4dannjjm 800 16 horses horse NNS cord-023095-4dannjjm 800 17 , , , cord-023095-4dannjjm 800 18 and and CC cord-023095-4dannjjm 800 19 it -PRON- PRP cord-023095-4dannjjm 800 20 is be VBZ cord-023095-4dannjjm 800 21 unclear unclear JJ cord-023095-4dannjjm 800 22 whether whether IN cord-023095-4dannjjm 800 23 fecal fecal JJ cord-023095-4dannjjm 800 24 samples sample NNS cord-023095-4dannjjm 800 25 are be VBP cord-023095-4dannjjm 800 26 good good JJ cord-023095-4dannjjm 800 27 predictors predictor NNS cord-023095-4dannjjm 800 28 of of IN cord-023095-4dannjjm 800 29 the the DT cord-023095-4dannjjm 800 30 status status NN cord-023095-4dannjjm 800 31 of of IN cord-023095-4dannjjm 800 32 proximal proximal JJ cord-023095-4dannjjm 800 33 intestinal intestinal JJ cord-023095-4dannjjm 800 34 sites site NNS cord-023095-4dannjjm 800 35 . . . cord-023095-4dannjjm 801 1 The the DT cord-023095-4dannjjm 801 2 objectives objective NNS cord-023095-4dannjjm 801 3 of of IN cord-023095-4dannjjm 801 4 this this DT cord-023095-4dannjjm 801 5 study study NN cord-023095-4dannjjm 801 6 were be VBD cord-023095-4dannjjm 801 7 to to TO cord-023095-4dannjjm 801 8 investigate investigate VB cord-023095-4dannjjm 801 9 the the DT cord-023095-4dannjjm 801 10 presence presence NN cord-023095-4dannjjm 801 11 of of IN cord-023095-4dannjjm 801 12 C. C. NNP cord-023095-4dannjjm 801 13 difficile difficile NNP cord-023095-4dannjjm 801 14 and and CC cord-023095-4dannjjm 801 15 C. C. NNP cord-023095-4dannjjm 801 16 perfringens perfringen NNS cord-023095-4dannjjm 801 17 in in IN cord-023095-4dannjjm 801 18 various various JJ cord-023095-4dannjjm 801 19 intestinal intestinal JJ cord-023095-4dannjjm 801 20 compartments compartment NNS cord-023095-4dannjjm 801 21 of of IN cord-023095-4dannjjm 801 22 healthy healthy JJ cord-023095-4dannjjm 801 23 adult adult NN cord-023095-4dannjjm 801 24 horses horse NNS cord-023095-4dannjjm 801 25 and and CC cord-023095-4dannjjm 801 26 to to TO cord-023095-4dannjjm 801 27 molecularly molecularly RB cord-023095-4dannjjm 801 28 characterize characterize VB cord-023095-4dannjjm 801 29 isolates isolate NNS cord-023095-4dannjjm 801 30 . . . cord-023095-4dannjjm 802 1 Intestinal intestinal JJ cord-023095-4dannjjm 802 2 contents content NNS cord-023095-4dannjjm 802 3 were be VBD cord-023095-4dannjjm 802 4 collected collect VBN cord-023095-4dannjjm 802 5 from from IN cord-023095-4dannjjm 802 6 the the DT cord-023095-4dannjjm 802 7 stomach stomach NN cord-023095-4dannjjm 802 8 , , , cord-023095-4dannjjm 802 9 duodenum duodenum NN cord-023095-4dannjjm 802 10 jejunum jejunum NNS cord-023095-4dannjjm 802 11 , , , cord-023095-4dannjjm 802 12 ileum ileum NN cord-023095-4dannjjm 802 13 , , , cord-023095-4dannjjm 802 14 cecum cecum NN cord-023095-4dannjjm 802 15 , , , cord-023095-4dannjjm 802 16 right right JJ cord-023095-4dannjjm 802 17 dorsal dorsal NN cord-023095-4dannjjm 802 18 and and CC cord-023095-4dannjjm 802 19 left left JJ cord-023095-4dannjjm 802 20 ventral ventral JJ cord-023095-4dannjjm 802 21 colon colon NN cord-023095-4dannjjm 802 22 , , , cord-023095-4dannjjm 802 23 small small JJ cord-023095-4dannjjm 802 24 colon colon NN cord-023095-4dannjjm 802 25 and and CC cord-023095-4dannjjm 802 26 rectum rectum NN cord-023095-4dannjjm 802 27 of of IN cord-023095-4dannjjm 802 28 10 10 CD cord-023095-4dannjjm 802 29 euthanized euthanize VBN cord-023095-4dannjjm 802 30 horses horse NNS cord-023095-4dannjjm 802 31 free free JJ cord-023095-4dannjjm 802 32 of of IN cord-023095-4dannjjm 802 33 apparent apparent JJ cord-023095-4dannjjm 802 34 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 802 35 disease disease NN cord-023095-4dannjjm 802 36 . . . cord-023095-4dannjjm 803 1 Enrichment enrichment NN cord-023095-4dannjjm 803 2 culture culture NN cord-023095-4dannjjm 803 3 was be VBD cord-023095-4dannjjm 803 4 performed perform VBN cord-023095-4dannjjm 803 5 for for IN cord-023095-4dannjjm 803 6 C. C. NNP cord-023095-4dannjjm 803 7 difficile difficile NNP cord-023095-4dannjjm 803 8 and and CC cord-023095-4dannjjm 803 9 C. C. NNP cord-023095-4dannjjm 803 10 perfringens perfringen NNS cord-023095-4dannjjm 803 11 and and CC cord-023095-4dannjjm 803 12 C. C. NNP cord-023095-4dannjjm 803 13 difficile difficile NN cord-023095-4dannjjm 803 14 isolates isolate NNS cord-023095-4dannjjm 803 15 were be VBD cord-023095-4dannjjm 803 16 further further RB cord-023095-4dannjjm 803 17 characterized characterize VBN cord-023095-4dannjjm 803 18 via via IN cord-023095-4dannjjm 803 19 toxin toxin NN cord-023095-4dannjjm 803 20 gene gene NN cord-023095-4dannjjm 803 21 detection detection NN cord-023095-4dannjjm 803 22 and and CC cord-023095-4dannjjm 803 23 ribotyping ribotyping NN cord-023095-4dannjjm 803 24 . . . cord-023095-4dannjjm 804 1 C. C. NNP cord-023095-4dannjjm 804 2 difficile difficile NNP cord-023095-4dannjjm 804 3 was be VBD cord-023095-4dannjjm 804 4 isolated isolate VBN cord-023095-4dannjjm 804 5 from from IN cord-023095-4dannjjm 804 6 9/90 9/90 CD cord-023095-4dannjjm 804 7 ( ( -LRB- cord-023095-4dannjjm 804 8 10 10 CD cord-023095-4dannjjm 804 9 % % NN cord-023095-4dannjjm 804 10 ) ) -RRB- cord-023095-4dannjjm 804 11 samples sample NNS cord-023095-4dannjjm 804 12 from from IN cord-023095-4dannjjm 804 13 5/10 5/10 CD cord-023095-4dannjjm 804 14 ( ( -LRB- cord-023095-4dannjjm 804 15 50 50 CD cord-023095-4dannjjm 804 16 % % NN cord-023095-4dannjjm 804 17 ) ) -RRB- cord-023095-4dannjjm 804 18 horses horse NNS cord-023095-4dannjjm 804 19 . . . cord-023095-4dannjjm 805 1 Between between IN cord-023095-4dannjjm 805 2 zero zero CD cord-023095-4dannjjm 805 3 and and CC cord-023095-4dannjjm 805 4 three three CD cord-023095-4dannjjm 805 5 sites site NNS cord-023095-4dannjjm 805 6 were be VBD cord-023095-4dannjjm 805 7 positive positive JJ cord-023095-4dannjjm 805 8 per per IN cord-023095-4dannjjm 805 9 horse horse NN cord-023095-4dannjjm 805 10 , , , cord-023095-4dannjjm 805 11 and and CC cord-023095-4dannjjm 805 12 multiple multiple JJ cord-023095-4dannjjm 805 13 sites site NNS cord-023095-4dannjjm 805 14 were be VBD cord-023095-4dannjjm 805 15 positive positive JJ cord-023095-4dannjjm 805 16 in in IN cord-023095-4dannjjm 805 17 three three CD cord-023095-4dannjjm 805 18 horses horse NNS cord-023095-4dannjjm 805 19 . . . cord-023095-4dannjjm 806 1 Isolates isolate NNS cord-023095-4dannjjm 806 2 were be VBD cord-023095-4dannjjm 806 3 recovered recover VBN cord-023095-4dannjjm 806 4 from from IN cord-023095-4dannjjm 806 5 duodenum duodenum NNP cord-023095-4dannjjm 806 6 ( ( -LRB- cord-023095-4dannjjm 806 7 n n NN cord-023095-4dannjjm 806 8 5 5 CD cord-023095-4dannjjm 806 9 1 1 CD cord-023095-4dannjjm 806 10 ) ) -RRB- cord-023095-4dannjjm 806 11 , , , cord-023095-4dannjjm 806 12 right right JJ cord-023095-4dannjjm 806 13 dorsal dorsal JJ cord-023095-4dannjjm 806 14 colon colon NN cord-023095-4dannjjm 806 15 ( ( -LRB- cord-023095-4dannjjm 806 16 n n NN cord-023095-4dannjjm 806 17 5 5 CD cord-023095-4dannjjm 806 18 3 3 CD cord-023095-4dannjjm 806 19 ) ) -RRB- cord-023095-4dannjjm 806 20 , , , cord-023095-4dannjjm 806 21 small small JJ cord-023095-4dannjjm 806 22 colon colon NN cord-023095-4dannjjm 806 23 ( ( -LRB- cord-023095-4dannjjm 806 24 n n NN cord-023095-4dannjjm 806 25 5 5 CD cord-023095-4dannjjm 806 26 1 1 CD cord-023095-4dannjjm 806 27 ) ) -RRB- cord-023095-4dannjjm 806 28 and and CC cord-023095-4dannjjm 806 29 rectum rectum NN cord-023095-4dannjjm 806 30 ( ( -LRB- cord-023095-4dannjjm 806 31 n n NN cord-023095-4dannjjm 806 32 5 5 CD cord-023095-4dannjjm 806 33 4 4 CD cord-023095-4dannjjm 806 34 ) ) -RRB- cord-023095-4dannjjm 806 35 . . . cord-023095-4dannjjm 807 1 In in IN cord-023095-4dannjjm 807 2 one one CD cord-023095-4dannjjm 807 3 horse horse NN cord-023095-4dannjjm 807 4 , , , cord-023095-4dannjjm 807 5 the the DT cord-023095-4dannjjm 807 6 rectal rectal JJ cord-023095-4dannjjm 807 7 sample sample NN cord-023095-4dannjjm 807 8 was be VBD cord-023095-4dannjjm 807 9 negative negative JJ cord-023095-4dannjjm 807 10 but but CC cord-023095-4dannjjm 807 11 C. C. NNP cord-023095-4dannjjm 807 12 difficile difficile NNP cord-023095-4dannjjm 807 13 was be VBD cord-023095-4dannjjm 807 14 isolated isolate VBN cord-023095-4dannjjm 807 15 from from IN cord-023095-4dannjjm 807 16 a a DT cord-023095-4dannjjm 807 17 proximal proximal JJ cord-023095-4dannjjm 807 18 site site NN cord-023095-4dannjjm 807 19 , , , cord-023095-4dannjjm 807 20 all all DT cord-023095-4dannjjm 807 21 other other JJ cord-023095-4dannjjm 807 22 horses horse NNS cord-023095-4dannjjm 807 23 were be VBD cord-023095-4dannjjm 807 24 positive positive JJ cord-023095-4dannjjm 807 25 on on IN cord-023095-4dannjjm 807 26 the the DT cord-023095-4dannjjm 807 27 rectal rectal JJ cord-023095-4dannjjm 807 28 sample sample NN cord-023095-4dannjjm 807 29 if if IN cord-023095-4dannjjm 807 30 a a DT cord-023095-4dannjjm 807 31 more more RBR cord-023095-4dannjjm 807 32 proximal proximal JJ cord-023095-4dannjjm 807 33 compartment compartment NN cord-023095-4dannjjm 807 34 was be VBD cord-023095-4dannjjm 807 35 positive positive JJ cord-023095-4dannjjm 807 36 . . . cord-023095-4dannjjm 808 1 In in IN cord-023095-4dannjjm 808 2 three three CD cord-023095-4dannjjm 808 3 horses horse NNS cord-023095-4dannjjm 808 4 multiple multiple JJ cord-023095-4dannjjm 808 5 compartments compartment NNS cord-023095-4dannjjm 808 6 were be VBD cord-023095-4dannjjm 808 7 positive positive JJ cord-023095-4dannjjm 808 8 however however RB cord-023095-4dannjjm 808 9 different different JJ cord-023095-4dannjjm 808 10 strains strain NNS cord-023095-4dannjjm 808 11 were be VBD cord-023095-4dannjjm 808 12 always always RB cord-023095-4dannjjm 808 13 present present JJ cord-023095-4dannjjm 808 14 within within IN cord-023095-4dannjjm 808 15 the the DT cord-023095-4dannjjm 808 16 same same JJ cord-023095-4dannjjm 808 17 horse horse NN cord-023095-4dannjjm 808 18 ( ( -LRB- cord-023095-4dannjjm 808 19 n n NN cord-023095-4dannjjm 808 20 5 5 CD cord-023095-4dannjjm 808 21 2 2 CD cord-023095-4dannjjm 808 22 ) ) -RRB- cord-023095-4dannjjm 808 23 . . . cord-023095-4dannjjm 809 1 All all DT cord-023095-4dannjjm 809 2 isolates isolate NNS cord-023095-4dannjjm 809 3 possessed possess VBD cord-023095-4dannjjm 809 4 genes gene NNS cord-023095-4dannjjm 809 5 encoding encode VBG cord-023095-4dannjjm 809 6 toxins toxin NNS cord-023095-4dannjjm 809 7 A A NNP cord-023095-4dannjjm 809 8 and and CC cord-023095-4dannjjm 809 9 B. B. NNP cord-023095-4dannjjm 809 10 Five five CD cord-023095-4dannjjm 809 11 isolates isolate NNS cord-023095-4dannjjm 809 12 were be VBD cord-023095-4dannjjm 809 13 ribotype ribotype NNP cord-023095-4dannjjm 809 14 078 078 CD cord-023095-4dannjjm 809 15 and and CC cord-023095-4dannjjm 809 16 also also RB cord-023095-4dannjjm 809 17 possessed possess VBD cord-023095-4dannjjm 809 18 genes gene NNS cord-023095-4dannjjm 809 19 encoding encode VBG cord-023095-4dannjjm 809 20 the the DT cord-023095-4dannjjm 809 21 binary binary JJ cord-023095-4dannjjm 809 22 toxin toxin NN cord-023095-4dannjjm 809 23 . . . cord-023095-4dannjjm 810 1 The the DT cord-023095-4dannjjm 810 2 other other JJ cord-023095-4dannjjm 810 3 isolates isolate NNS cord-023095-4dannjjm 810 4 were be VBD cord-023095-4dannjjm 810 5 ribotype ribotype NNP cord-023095-4dannjjm 810 6 001 001 CD cord-023095-4dannjjm 810 7 and and CC cord-023095-4dannjjm 810 8 were be VBD cord-023095-4dannjjm 810 9 negative negative JJ cord-023095-4dannjjm 810 10 for for IN cord-023095-4dannjjm 810 11 the the DT cord-023095-4dannjjm 810 12 genes gene NNS cord-023095-4dannjjm 810 13 encoding encode VBG cord-023095-4dannjjm 810 14 the the DT cord-023095-4dannjjm 810 15 binary binary JJ cord-023095-4dannjjm 810 16 toxin toxin NN cord-023095-4dannjjm 810 17 . . . cord-023095-4dannjjm 811 1 Despite despite IN cord-023095-4dannjjm 811 2 using use VBG cord-023095-4dannjjm 811 3 a a DT cord-023095-4dannjjm 811 4 method method NN cord-023095-4dannjjm 811 5 with with IN cord-023095-4dannjjm 811 6 a a DT cord-023095-4dannjjm 811 7 detection detection NN cord-023095-4dannjjm 811 8 level level NN cord-023095-4dannjjm 811 9 as as RB cord-023095-4dannjjm 811 10 low low JJ cord-023095-4dannjjm 811 11 as as IN cord-023095-4dannjjm 811 12 9 9 CD cord-023095-4dannjjm 811 13 cfu cfu NN cord-023095-4dannjjm 811 14 / / SYM cord-023095-4dannjjm 811 15 g g NN cord-023095-4dannjjm 811 16 of of IN cord-023095-4dannjjm 811 17 feces fece NNS cord-023095-4dannjjm 811 18 , , , cord-023095-4dannjjm 811 19 no no DT cord-023095-4dannjjm 811 20 C. C. NNP cord-023095-4dannjjm 811 21 perfringens perfringen NNS cord-023095-4dannjjm 811 22 was be VBD cord-023095-4dannjjm 811 23 recovered recover VBN cord-023095-4dannjjm 811 24 . . . cord-023095-4dannjjm 812 1 Rectal rectal JJ cord-023095-4dannjjm 812 2 samples sample NNS cord-023095-4dannjjm 812 3 were be VBD cord-023095-4dannjjm 812 4 a a DT cord-023095-4dannjjm 812 5 good good JJ cord-023095-4dannjjm 812 6 predictor predictor NN cord-023095-4dannjjm 812 7 of of IN cord-023095-4dannjjm 812 8 overall overall JJ cord-023095-4dannjjm 812 9 C. C. NNP cord-023095-4dannjjm 812 10 difficile difficile NN cord-023095-4dannjjm 812 11 carrier carrier NN cord-023095-4dannjjm 812 12 status status NN cord-023095-4dannjjm 812 13 ( ( -LRB- cord-023095-4dannjjm 812 14 4/5 4/5 CD cord-023095-4dannjjm 812 15 horses horse NNS cord-023095-4dannjjm 812 16 ) ) -RRB- cord-023095-4dannjjm 812 17 , , , cord-023095-4dannjjm 812 18 however however RB cord-023095-4dannjjm 812 19 rectal rectal JJ cord-023095-4dannjjm 812 20 samples sample NNS cord-023095-4dannjjm 812 21 were be VBD cord-023095-4dannjjm 812 22 not not RB cord-023095-4dannjjm 812 23 always always RB cord-023095-4dannjjm 812 24 representative representative JJ cord-023095-4dannjjm 812 25 for for IN cord-023095-4dannjjm 812 26 the the DT cord-023095-4dannjjm 812 27 ribotype ribotype NNP cord-023095-4dannjjm 812 28 carried carry VBD cord-023095-4dannjjm 812 29 in in IN cord-023095-4dannjjm 812 30 more more RBR cord-023095-4dannjjm 812 31 proximal proximal JJ cord-023095-4dannjjm 812 32 compartments compartment NNS cord-023095-4dannjjm 812 33 . . . cord-023095-4dannjjm 813 1 The the DT cord-023095-4dannjjm 813 2 presence presence NN cord-023095-4dannjjm 813 3 of of IN cord-023095-4dannjjm 813 4 variable variable JJ cord-023095-4dannjjm 813 5 strains strain NNS cord-023095-4dannjjm 813 6 within within IN cord-023095-4dannjjm 813 7 the the DT cord-023095-4dannjjm 813 8 same same JJ cord-023095-4dannjjm 813 9 horse horse NN cord-023095-4dannjjm 813 10 suggests suggest VBZ cord-023095-4dannjjm 813 11 transient transient JJ cord-023095-4dannjjm 813 12 passage passage NN cord-023095-4dannjjm 813 13 of of IN cord-023095-4dannjjm 813 14 the the DT cord-023095-4dannjjm 813 15 bacterium bacterium NN cord-023095-4dannjjm 813 16 through through IN cord-023095-4dannjjm 813 17 the the DT cord-023095-4dannjjm 813 18 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 813 19 system system NN cord-023095-4dannjjm 813 20 rather rather RB cord-023095-4dannjjm 813 21 than than IN cord-023095-4dannjjm 813 22 actual actual JJ cord-023095-4dannjjm 813 23 colonization colonization NN cord-023095-4dannjjm 813 24 although although IN cord-023095-4dannjjm 813 25 further further JJ cord-023095-4dannjjm 813 26 study study NN cord-023095-4dannjjm 813 27 testing test VBG cord-023095-4dannjjm 813 28 multiple multiple JJ cord-023095-4dannjjm 813 29 colonies colony NNS cord-023095-4dannjjm 813 30 per per IN cord-023095-4dannjjm 813 31 site site NN cord-023095-4dannjjm 813 32 is be VBZ cord-023095-4dannjjm 813 33 needed need VBN cord-023095-4dannjjm 813 34 . . . cord-023095-4dannjjm 814 1 The the DT cord-023095-4dannjjm 814 2 predominance predominance NN cord-023095-4dannjjm 814 3 of of IN cord-023095-4dannjjm 814 4 ribotype ribotype NNP cord-023095-4dannjjm 814 5 078 078 CD cord-023095-4dannjjm 814 6 is be VBZ cord-023095-4dannjjm 814 7 consistent consistent JJ cord-023095-4dannjjm 814 8 with with IN cord-023095-4dannjjm 814 9 recent recent JJ cord-023095-4dannjjm 814 10 emergence emergence NN cord-023095-4dannjjm 814 11 of of IN cord-023095-4dannjjm 814 12 this this DT cord-023095-4dannjjm 814 13 strain strain NN cord-023095-4dannjjm 814 14 in in IN cord-023095-4dannjjm 814 15 this this DT cord-023095-4dannjjm 814 16 region region NN cord-023095-4dannjjm 814 17 , , , cord-023095-4dannjjm 814 18 as as IN cord-023095-4dannjjm 814 19 earlier early JJR cord-023095-4dannjjm 814 20 studies study NNS cord-023095-4dannjjm 814 21 found find VBD cord-023095-4dannjjm 814 22 other other JJ cord-023095-4dannjjm 814 23 strains strain NNS cord-023095-4dannjjm 814 24 ( ( -LRB- cord-023095-4dannjjm 814 25 027 027 CD cord-023095-4dannjjm 814 26 , , , cord-023095-4dannjjm 814 27 001 001 CD cord-023095-4dannjjm 814 28 ) ) -RRB- cord-023095-4dannjjm 814 29 to to TO cord-023095-4dannjjm 814 30 be be VB cord-023095-4dannjjm 814 31 more more RBR cord-023095-4dannjjm 814 32 prevalent prevalent JJ cord-023095-4dannjjm 814 33 and and CC cord-023095-4dannjjm 814 34 a a DT cord-023095-4dannjjm 814 35 variety variety NN cord-023095-4dannjjm 814 36 of of IN cord-023095-4dannjjm 814 37 ribotypes ribotype NNS cord-023095-4dannjjm 814 38 were be VBD cord-023095-4dannjjm 814 39 typically typically RB cord-023095-4dannjjm 814 40 recovered recover VBN cord-023095-4dannjjm 814 41 from from IN cord-023095-4dannjjm 814 42 horses horse NNS cord-023095-4dannjjm 814 43 . . . cord-023095-4dannjjm 815 1 Interestingly interestingly RB cord-023095-4dannjjm 815 2 ribotype ribotype NNP cord-023095-4dannjjm 815 3 078 078 CD cord-023095-4dannjjm 815 4 has have VBZ cord-023095-4dannjjm 815 5 recently recently RB cord-023095-4dannjjm 815 6 emerged emerge VBN cord-023095-4dannjjm 815 7 as as IN cord-023095-4dannjjm 815 8 a a DT cord-023095-4dannjjm 815 9 hypervirulent hypervirulent NN cord-023095-4dannjjm 815 10 strain strain NN cord-023095-4dannjjm 815 11 in in IN cord-023095-4dannjjm 815 12 humans human NNS cord-023095-4dannjjm 815 13 in in IN cord-023095-4dannjjm 815 14 our -PRON- PRP$ cord-023095-4dannjjm 815 15 area area NN cord-023095-4dannjjm 815 16 . . . cord-023095-4dannjjm 816 1 Clostridium clostridium NN cord-023095-4dannjjm 816 2 difficile difficile NN cord-023095-4dannjjm 816 3 , , , cord-023095-4dannjjm 816 4 Clostridium clostridium NN cord-023095-4dannjjm 816 5 perfringens perfringen NNS cord-023095-4dannjjm 816 6 and and CC cord-023095-4dannjjm 816 7 Salmonella Salmonella NNP cord-023095-4dannjjm 816 8 are be VBP cord-023095-4dannjjm 816 9 important important JJ cord-023095-4dannjjm 816 10 enteric enteric JJ cord-023095-4dannjjm 816 11 pathogens pathogen NNS cord-023095-4dannjjm 816 12 in in IN cord-023095-4dannjjm 816 13 horses horse NNS cord-023095-4dannjjm 816 14 , , , cord-023095-4dannjjm 816 15 however however RB cord-023095-4dannjjm 816 16 some some DT cord-023095-4dannjjm 816 17 healthy healthy JJ cord-023095-4dannjjm 816 18 animals animal NNS cord-023095-4dannjjm 816 19 also also RB cord-023095-4dannjjm 816 20 harbour harbour VBP cord-023095-4dannjjm 816 21 these these DT cord-023095-4dannjjm 816 22 pathogens pathogen NNS cord-023095-4dannjjm 816 23 . . . cord-023095-4dannjjm 817 1 Point point NN cord-023095-4dannjjm 817 2 prevalence prevalence NN cord-023095-4dannjjm 817 3 studies study NNS cord-023095-4dannjjm 817 4 have have VBP cord-023095-4dannjjm 817 5 reported report VBN cord-023095-4dannjjm 817 6 these these DT cord-023095-4dannjjm 817 7 carriage carriage NN cord-023095-4dannjjm 817 8 rates rate NNS cord-023095-4dannjjm 817 9 , , , cord-023095-4dannjjm 817 10 but but CC cord-023095-4dannjjm 817 11 there there EX cord-023095-4dannjjm 817 12 are be VBP cord-023095-4dannjjm 817 13 no no DT cord-023095-4dannjjm 817 14 data datum NNS cord-023095-4dannjjm 817 15 regarding regard VBG cord-023095-4dannjjm 817 16 longitudinal longitudinal JJ cord-023095-4dannjjm 817 17 prevalence prevalence NN cord-023095-4dannjjm 817 18 of of IN cord-023095-4dannjjm 817 19 these these DT cord-023095-4dannjjm 817 20 enteric enteric JJ cord-023095-4dannjjm 817 21 bacteria bacteria NNS cord-023095-4dannjjm 817 22 , , , cord-023095-4dannjjm 817 23 information information NN cord-023095-4dannjjm 817 24 that that WDT cord-023095-4dannjjm 817 25 would would MD cord-023095-4dannjjm 817 26 be be VB cord-023095-4dannjjm 817 27 useful useful JJ cord-023095-4dannjjm 817 28 to to TO cord-023095-4dannjjm 817 29 better better RB cord-023095-4dannjjm 817 30 understand understand VB cord-023095-4dannjjm 817 31 the the DT cord-023095-4dannjjm 817 32 epidemiology epidemiology NN cord-023095-4dannjjm 817 33 of of IN cord-023095-4dannjjm 817 34 these these DT cord-023095-4dannjjm 817 35 pathogens pathogen NNS cord-023095-4dannjjm 817 36 . . . cord-023095-4dannjjm 818 1 Additionally additionally RB cord-023095-4dannjjm 818 2 , , , cord-023095-4dannjjm 818 3 antimicrobial antimicrobial JJ cord-023095-4dannjjm 818 4 resistance resistance NN cord-023095-4dannjjm 818 5 is be VBZ cord-023095-4dannjjm 818 6 a a DT cord-023095-4dannjjm 818 7 pressing press VBG cord-023095-4dannjjm 818 8 concern concern NN cord-023095-4dannjjm 818 9 . . . cord-023095-4dannjjm 819 1 Commensal Commensal NNP cord-023095-4dannjjm 819 2 E.coli E.coli NNS cord-023095-4dannjjm 819 3 is be VBZ cord-023095-4dannjjm 819 4 often often RB cord-023095-4dannjjm 819 5 used use VBN cord-023095-4dannjjm 819 6 as as IN cord-023095-4dannjjm 819 7 an an DT cord-023095-4dannjjm 819 8 indicator indicator NN cord-023095-4dannjjm 819 9 organism organism NN cord-023095-4dannjjm 819 10 to to TO cord-023095-4dannjjm 819 11 evaluate evaluate VB cord-023095-4dannjjm 819 12 antimicrobial antimicrobial JJ cord-023095-4dannjjm 819 13 resistance resistance NN cord-023095-4dannjjm 819 14 of of IN cord-023095-4dannjjm 819 15 enteric enteric JJ cord-023095-4dannjjm 819 16 bacteria bacteria NNS cord-023095-4dannjjm 819 17 , , , cord-023095-4dannjjm 819 18 yet yet CC cord-023095-4dannjjm 819 19 there there EX cord-023095-4dannjjm 819 20 are be VBP cord-023095-4dannjjm 819 21 limited limited JJ cord-023095-4dannjjm 819 22 data datum NNS cord-023095-4dannjjm 819 23 from from IN cord-023095-4dannjjm 819 24 horses horse NNS cord-023095-4dannjjm 819 25 on on IN cord-023095-4dannjjm 819 26 farms farm NNS cord-023095-4dannjjm 819 27 . . . cord-023095-4dannjjm 820 1 The the DT cord-023095-4dannjjm 820 2 objectives objective NNS cord-023095-4dannjjm 820 3 of of IN cord-023095-4dannjjm 820 4 this this DT cord-023095-4dannjjm 820 5 study study NN cord-023095-4dannjjm 820 6 were be VBD cord-023095-4dannjjm 820 7 to to TO cord-023095-4dannjjm 820 8 longitudinally longitudinally RB cord-023095-4dannjjm 820 9 investigate investigate VB cord-023095-4dannjjm 820 10 the the DT cord-023095-4dannjjm 820 11 above above JJ cord-023095-4dannjjm 820 12 enteric enteric JJ cord-023095-4dannjjm 820 13 pathogens pathogen NNS cord-023095-4dannjjm 820 14 over over IN cord-023095-4dannjjm 820 15 the the DT cord-023095-4dannjjm 820 16 course course NN cord-023095-4dannjjm 820 17 of of IN cord-023095-4dannjjm 820 18 one one CD cord-023095-4dannjjm 820 19 year year NN cord-023095-4dannjjm 820 20 , , , cord-023095-4dannjjm 820 21 molecularly molecularly RB cord-023095-4dannjjm 820 22 characterize characterize VB cord-023095-4dannjjm 820 23 obtained obtain VBN cord-023095-4dannjjm 820 24 isolates isolate NNS cord-023095-4dannjjm 820 25 and and CC cord-023095-4dannjjm 820 26 determine determine VB cord-023095-4dannjjm 820 27 the the DT cord-023095-4dannjjm 820 28 antibiotic antibiotic JJ cord-023095-4dannjjm 820 29 susceptibility susceptibility NN cord-023095-4dannjjm 820 30 profile profile NN cord-023095-4dannjjm 820 31 for for IN cord-023095-4dannjjm 820 32 E. E. NNP cord-023095-4dannjjm 820 33 coli coli NNS cord-023095-4dannjjm 820 34 . . . cord-023095-4dannjjm 821 1 Fecal fecal JJ cord-023095-4dannjjm 821 2 samples sample NNS cord-023095-4dannjjm 821 3 were be VBD cord-023095-4dannjjm 821 4 collected collect VBN cord-023095-4dannjjm 821 5 from from IN cord-023095-4dannjjm 821 6 25 25 CD cord-023095-4dannjjm 821 7 adult adult NN cord-023095-4dannjjm 821 8 horses horse NNS cord-023095-4dannjjm 821 9 from from IN cord-023095-4dannjjm 821 10 five five CD cord-023095-4dannjjm 821 11 farms farm NNS cord-023095-4dannjjm 821 12 on on IN cord-023095-4dannjjm 821 13 a a DT cord-023095-4dannjjm 821 14 monthly monthly JJ cord-023095-4dannjjm 821 15 basis basis NN cord-023095-4dannjjm 821 16 over over IN cord-023095-4dannjjm 821 17 the the DT cord-023095-4dannjjm 821 18 course course NN cord-023095-4dannjjm 821 19 of of IN cord-023095-4dannjjm 821 20 one one CD cord-023095-4dannjjm 821 21 year year NN cord-023095-4dannjjm 821 22 . . . cord-023095-4dannjjm 822 1 Selective selective JJ cord-023095-4dannjjm 822 2 cultures culture NNS cord-023095-4dannjjm 822 3 were be VBD cord-023095-4dannjjm 822 4 performed perform VBN cord-023095-4dannjjm 822 5 for for IN cord-023095-4dannjjm 822 6 C. C. NNP cord-023095-4dannjjm 822 7 difficile difficile NNP cord-023095-4dannjjm 822 8 , , , cord-023095-4dannjjm 822 9 C. C. NNP cord-023095-4dannjjm 822 10 perfringens perfringen NNS cord-023095-4dannjjm 822 11 , , , cord-023095-4dannjjm 822 12 Salmonella Salmonella NNP cord-023095-4dannjjm 822 13 and and CC cord-023095-4dannjjm 822 14 E. E. NNP cord-023095-4dannjjm 822 15 coli coli NNS cord-023095-4dannjjm 822 16 . . . cord-023095-4dannjjm 823 1 C. C. NNP cord-023095-4dannjjm 823 2 difficile difficile NN cord-023095-4dannjjm 823 3 isolates isolate NNS cord-023095-4dannjjm 823 4 were be VBD cord-023095-4dannjjm 823 5 characterized characterize VBN cord-023095-4dannjjm 823 6 via via IN cord-023095-4dannjjm 823 7 toxin toxin NN cord-023095-4dannjjm 823 8 gene gene NN cord-023095-4dannjjm 823 9 PCR PCR NNP cord-023095-4dannjjm 823 10 and and CC cord-023095-4dannjjm 823 11 ribotyping ribotype VBG cord-023095-4dannjjm 823 12 . . . cord-023095-4dannjjm 824 1 Broth Broth NNP cord-023095-4dannjjm 824 2 microdilution microdilution NN cord-023095-4dannjjm 824 3 was be VBD cord-023095-4dannjjm 824 4 performed perform VBN cord-023095-4dannjjm 824 5 to to TO cord-023095-4dannjjm 824 6 assess assess VB cord-023095-4dannjjm 824 7 antimicrobial antimicrobial JJ cord-023095-4dannjjm 824 8 susceptibility susceptibility NN cord-023095-4dannjjm 824 9 profiles profile NNS cord-023095-4dannjjm 824 10 of of IN cord-023095-4dannjjm 824 11 E. E. NNP cord-023095-4dannjjm 824 12 coli coli NNS cord-023095-4dannjjm 824 13 . . . cord-023095-4dannjjm 825 1 Clostridium clostridium NN cord-023095-4dannjjm 825 2 difficile difficile NN cord-023095-4dannjjm 825 3 was be VBD cord-023095-4dannjjm 825 4 isolated isolate VBN cord-023095-4dannjjm 825 5 from from IN cord-023095-4dannjjm 825 6 15/275 15/275 CD cord-023095-4dannjjm 825 7 ( ( -LRB- cord-023095-4dannjjm 825 8 5.45 5.45 CD cord-023095-4dannjjm 825 9 % % NN cord-023095-4dannjjm 825 10 ) ) -RRB- cord-023095-4dannjjm 825 11 samples sample NNS cord-023095-4dannjjm 825 12 from from IN cord-023095-4dannjjm 825 13 11/25 11/25 CD cord-023095-4dannjjm 825 14 ( ( -LRB- cord-023095-4dannjjm 825 15 44 44 CD cord-023095-4dannjjm 825 16 % % NN cord-023095-4dannjjm 825 17 ) ) -RRB- cord-023095-4dannjjm 825 18 horses horse NNS cord-023095-4dannjjm 825 19 . . . cord-023095-4dannjjm 826 1 Four four CD cord-023095-4dannjjm 826 2 horses horse NNS cord-023095-4dannjjm 826 3 were be VBD cord-023095-4dannjjm 826 4 positive positive JJ cord-023095-4dannjjm 826 5 on on IN cord-023095-4dannjjm 826 6 more more JJR cord-023095-4dannjjm 826 7 than than IN cord-023095-4dannjjm 826 8 one one CD cord-023095-4dannjjm 826 9 occasion occasion NN cord-023095-4dannjjm 826 10 , , , cord-023095-4dannjjm 826 11 three three CD cord-023095-4dannjjm 826 12 were be VBD cord-023095-4dannjjm 826 13 positive positive JJ cord-023095-4dannjjm 826 14 in in IN cord-023095-4dannjjm 826 15 two two CD cord-023095-4dannjjm 826 16 consecutive consecutive JJ cord-023095-4dannjjm 826 17 months month NNS cord-023095-4dannjjm 826 18 . . . cord-023095-4dannjjm 827 1 Different different JJ cord-023095-4dannjjm 827 2 ribotypes ribotype NNS cord-023095-4dannjjm 827 3 were be VBD cord-023095-4dannjjm 827 4 found find VBN cord-023095-4dannjjm 827 5 in in IN cord-023095-4dannjjm 827 6 two two CD cord-023095-4dannjjm 827 7 of of IN cord-023095-4dannjjm 827 8 the the DT cord-023095-4dannjjm 827 9 latter latter JJ cord-023095-4dannjjm 827 10 horses horse NNS cord-023095-4dannjjm 827 11 . . . cord-023095-4dannjjm 828 1 Most Most JJS cord-023095-4dannjjm 828 2 isolates isolate NNS cord-023095-4dannjjm 828 3 were be VBD cord-023095-4dannjjm 828 4 ribotype ribotype NNP cord-023095-4dannjjm 828 5 078 078 CD cord-023095-4dannjjm 829 1 ( ( -LRB- cord-023095-4dannjjm 829 2 n n NN cord-023095-4dannjjm 829 3 5 5 CD cord-023095-4dannjjm 829 4 6 6 CD cord-023095-4dannjjm 829 5 ) ) -RRB- cord-023095-4dannjjm 829 6 with with IN cord-023095-4dannjjm 829 7 ribotype ribotype NNP cord-023095-4dannjjm 829 8 001 001 CD cord-023095-4dannjjm 830 1 ( ( -LRB- cord-023095-4dannjjm 830 2 n n NN cord-023095-4dannjjm 830 3 5 5 CD cord-023095-4dannjjm 830 4 5 5 CD cord-023095-4dannjjm 830 5 ) ) -RRB- cord-023095-4dannjjm 830 6 and and CC cord-023095-4dannjjm 830 7 ribotype ribotype NNP cord-023095-4dannjjm 830 8 C C NNP cord-023095-4dannjjm 830 9 ( ( -LRB- cord-023095-4dannjjm 830 10 n n NN cord-023095-4dannjjm 830 11 5 5 CD cord-023095-4dannjjm 830 12 4 4 CD cord-023095-4dannjjm 830 13 ) ) -RRB- cord-023095-4dannjjm 830 14 also also RB cord-023095-4dannjjm 830 15 identified identify VBN cord-023095-4dannjjm 830 16 . . . cord-023095-4dannjjm 831 1 Ribotypes Ribotypes NNP cord-023095-4dannjjm 831 2 078 078 CD cord-023095-4dannjjm 831 3 and and CC cord-023095-4dannjjm 831 4 C C NNP cord-023095-4dannjjm 831 5 possessed possess VBD cord-023095-4dannjjm 831 6 genes gene NNS cord-023095-4dannjjm 831 7 encoding encode VBG cord-023095-4dannjjm 831 8 toxins toxin NNS cord-023095-4dannjjm 832 1 A a LS cord-023095-4dannjjm 832 2 , , , cord-023095-4dannjjm 832 3 B b NN cord-023095-4dannjjm 832 4 and and CC cord-023095-4dannjjm 832 5 binary binary JJ cord-023095-4dannjjm 832 6 toxin toxin NN cord-023095-4dannjjm 832 7 , , , cord-023095-4dannjjm 832 8 while while IN cord-023095-4dannjjm 832 9 ribotype ribotype NNP cord-023095-4dannjjm 832 10 001 001 CD cord-023095-4dannjjm 832 11 only only RB cord-023095-4dannjjm 832 12 possessed possess VBD cord-023095-4dannjjm 832 13 toxin toxin NN cord-023095-4dannjjm 832 14 A a NN cord-023095-4dannjjm 832 15 and and CC cord-023095-4dannjjm 832 16 B b NN cord-023095-4dannjjm 832 17 genes gene NNS cord-023095-4dannjjm 832 18 . . . cord-023095-4dannjjm 833 1 Despite despite IN cord-023095-4dannjjm 833 2 a a DT cord-023095-4dannjjm 833 3 detection detection NN cord-023095-4dannjjm 833 4 threshold threshold NN cord-023095-4dannjjm 833 5 of of IN cord-023095-4dannjjm 833 6 9 9 CD cord-023095-4dannjjm 833 7 cfu cfu NN cord-023095-4dannjjm 833 8 / / SYM cord-023095-4dannjjm 833 9 g g NNP cord-023095-4dannjjm 833 10 feces fece NNS cord-023095-4dannjjm 833 11 , , , cord-023095-4dannjjm 833 12 C. C. NNP cord-023095-4dannjjm 833 13 perfringens perfringen NNS cord-023095-4dannjjm 833 14 was be VBD cord-023095-4dannjjm 833 15 not not RB cord-023095-4dannjjm 833 16 detected detect VBN cord-023095-4dannjjm 833 17 in in IN cord-023095-4dannjjm 833 18 any any DT cord-023095-4dannjjm 833 19 samples sample NNS cord-023095-4dannjjm 833 20 , , , cord-023095-4dannjjm 833 21 nor nor CC cord-023095-4dannjjm 833 22 was be VBD cord-023095-4dannjjm 833 23 Salmonella Salmonella NNP cord-023095-4dannjjm 833 24 . . . cord-023095-4dannjjm 834 1 E e NN cord-023095-4dannjjm 834 2 coli coli NNS cord-023095-4dannjjm 834 3 was be VBD cord-023095-4dannjjm 834 4 isolated isolate VBN cord-023095-4dannjjm 834 5 from from IN cord-023095-4dannjjm 834 6 117/225 117/225 CD cord-023095-4dannjjm 834 7 ( ( -LRB- cord-023095-4dannjjm 834 8 52 52 CD cord-023095-4dannjjm 834 9 % % NN cord-023095-4dannjjm 834 10 ) ) -RRB- cord-023095-4dannjjm 834 11 samples sample NNS cord-023095-4dannjjm 834 12 . . . cord-023095-4dannjjm 835 1 Resistance resistance NN cord-023095-4dannjjm 835 2 to to IN cord-023095-4dannjjm 835 3 ! ! . cord-023095-4dannjjm 836 1 1 1 CD cord-023095-4dannjjm 836 2 antimicrobial antimicrobial NN cord-023095-4dannjjm 836 3 was be VBD cord-023095-4dannjjm 836 4 present present JJ cord-023095-4dannjjm 836 5 in in IN cord-023095-4dannjjm 836 6 only only RB cord-023095-4dannjjm 836 7 19/117 19/117 CD cord-023095-4dannjjm 836 8 ( ( -LRB- cord-023095-4dannjjm 836 9 16.9 16.9 CD cord-023095-4dannjjm 836 10 % % NN cord-023095-4dannjjm 836 11 ) ) -RRB- cord-023095-4dannjjm 836 12 isolates isolate NNS cord-023095-4dannjjm 836 13 . . . cord-023095-4dannjjm 837 1 Multidrug multidrug JJ cord-023095-4dannjjm 837 2 resistance resistance NN cord-023095-4dannjjm 837 3 ( ( -LRB- cord-023095-4dannjjm 837 4 ! ! . cord-023095-4dannjjm 837 5 3 3 CD cord-023095-4dannjjm 837 6 antibiotics antibiotic NNS cord-023095-4dannjjm 837 7 ) ) -RRB- cord-023095-4dannjjm 837 8 was be VBD cord-023095-4dannjjm 837 9 present present JJ cord-023095-4dannjjm 837 10 in in IN cord-023095-4dannjjm 837 11 5/117 5/117 CD cord-023095-4dannjjm 837 12 ( ( -LRB- cord-023095-4dannjjm 837 13 4 4 CD cord-023095-4dannjjm 837 14 % % NN cord-023095-4dannjjm 837 15 ) ) -RRB- cord-023095-4dannjjm 837 16 . . . cord-023095-4dannjjm 838 1 Most most RBS cord-023095-4dannjjm 838 2 commonly commonly RB cord-023095-4dannjjm 838 3 , , , cord-023095-4dannjjm 838 4 isolates isolate NNS cord-023095-4dannjjm 838 5 were be VBD cord-023095-4dannjjm 838 6 resistant resistant JJ cord-023095-4dannjjm 838 7 to to IN cord-023095-4dannjjm 838 8 sulfisoxazole sulfisoxazole NNP cord-023095-4dannjjm 838 9 ( ( -LRB- cord-023095-4dannjjm 838 10 17/ 17/ CD cord-023095-4dannjjm 838 11 117 117 CD cord-023095-4dannjjm 838 12 ) ) -RRB- cord-023095-4dannjjm 838 13 and and CC cord-023095-4dannjjm 838 14 trimethoprim trimethoprim NNP cord-023095-4dannjjm 838 15 sulfamethoxazole sulfamethoxazole NNP cord-023095-4dannjjm 838 16 ( ( -LRB- cord-023095-4dannjjm 838 17 16/117 16/117 CD cord-023095-4dannjjm 838 18 ) ) -RRB- cord-023095-4dannjjm 838 19 . . . cord-023095-4dannjjm 839 1 The the DT cord-023095-4dannjjm 839 2 overall overall JJ cord-023095-4dannjjm 839 3 detection detection NN cord-023095-4dannjjm 839 4 rate rate NN cord-023095-4dannjjm 839 5 for for IN cord-023095-4dannjjm 839 6 toxigenic toxigenic NNP cord-023095-4dannjjm 839 7 C. C. NNP cord-023095-4dannjjm 839 8 difficile difficile NN cord-023095-4dannjjm 839 9 in in IN cord-023095-4dannjjm 839 10 fecal fecal JJ cord-023095-4dannjjm 839 11 samples sample NNS cord-023095-4dannjjm 839 12 of of IN cord-023095-4dannjjm 839 13 healthy healthy JJ cord-023095-4dannjjm 839 14 horses horse NNS cord-023095-4dannjjm 839 15 was be VBD cord-023095-4dannjjm 839 16 5.4 5.4 CD cord-023095-4dannjjm 839 17 % % NN cord-023095-4dannjjm 839 18 which which WDT cord-023095-4dannjjm 839 19 is be VBZ cord-023095-4dannjjm 839 20 consistent consistent JJ cord-023095-4dannjjm 839 21 with with IN cord-023095-4dannjjm 839 22 previous previous JJ cord-023095-4dannjjm 839 23 studies study NNS cord-023095-4dannjjm 839 24 . . . cord-023095-4dannjjm 840 1 The the DT cord-023095-4dannjjm 840 2 cumulative cumulative JJ cord-023095-4dannjjm 840 3 prevalence prevalence NN cord-023095-4dannjjm 840 4 of of IN cord-023095-4dannjjm 840 5 44 44 CD cord-023095-4dannjjm 840 6 % % NN cord-023095-4dannjjm 840 7 was be VBD cord-023095-4dannjjm 840 8 striking striking JJ cord-023095-4dannjjm 840 9 but but CC cord-023095-4dannjjm 840 10 only only RB cord-023095-4dannjjm 840 11 one one CD cord-023095-4dannjjm 840 12 horse horse NN cord-023095-4dannjjm 840 13 shed shed VBD cord-023095-4dannjjm 840 14 the the DT cord-023095-4dannjjm 840 15 same same JJ cord-023095-4dannjjm 840 16 strain strain NN cord-023095-4dannjjm 840 17 for for IN cord-023095-4dannjjm 840 18 more more JJR cord-023095-4dannjjm 840 19 than than IN cord-023095-4dannjjm 840 20 one one CD cord-023095-4dannjjm 840 21 month month NN cord-023095-4dannjjm 840 22 , , , cord-023095-4dannjjm 840 23 indicating indicate VBG cord-023095-4dannjjm 840 24 C. C. NNP cord-023095-4dannjjm 840 25 difficile difficile NN cord-023095-4dannjjm 840 26 shedding shedding NN cord-023095-4dannjjm 840 27 is be VBZ cord-023095-4dannjjm 840 28 a a DT cord-023095-4dannjjm 840 29 transient transient JJ cord-023095-4dannjjm 840 30 and and CC cord-023095-4dannjjm 840 31 dynamic dynamic JJ cord-023095-4dannjjm 840 32 state state NN cord-023095-4dannjjm 840 33 . . . cord-023095-4dannjjm 841 1 The the DT cord-023095-4dannjjm 841 2 predominant predominant JJ cord-023095-4dannjjm 841 3 isolation isolation NN cord-023095-4dannjjm 841 4 of of IN cord-023095-4dannjjm 841 5 ribotype ribotype NNP cord-023095-4dannjjm 841 6 078 078 CD cord-023095-4dannjjm 841 7 is be VBZ cord-023095-4dannjjm 841 8 consistent consistent JJ cord-023095-4dannjjm 841 9 with with IN cord-023095-4dannjjm 841 10 the the DT cord-023095-4dannjjm 841 11 suspicion suspicion NN cord-023095-4dannjjm 841 12 that that IN cord-023095-4dannjjm 841 13 this this DT cord-023095-4dannjjm 841 14 strain strain NN cord-023095-4dannjjm 841 15 has have VBZ cord-023095-4dannjjm 841 16 emerged emerge VBN cord-023095-4dannjjm 841 17 and and CC cord-023095-4dannjjm 841 18 become become VBN cord-023095-4dannjjm 841 19 widely widely RB cord-023095-4dannjjm 841 20 disseminated disseminate VBN cord-023095-4dannjjm 841 21 in in IN cord-023095-4dannjjm 841 22 this this DT cord-023095-4dannjjm 841 23 region region NN cord-023095-4dannjjm 841 24 in in IN cord-023095-4dannjjm 841 25 recent recent JJ cord-023095-4dannjjm 841 26 years year NNS cord-023095-4dannjjm 841 27 . . . cord-023095-4dannjjm 842 1 The the DT cord-023095-4dannjjm 842 2 low low JJ cord-023095-4dannjjm 842 3 prevalence prevalence NN cord-023095-4dannjjm 842 4 of of IN cord-023095-4dannjjm 842 5 C. C. NNP cord-023095-4dannjjm 842 6 perfringens perfringen NNS cord-023095-4dannjjm 842 7 and and CC cord-023095-4dannjjm 842 8 Salmonella Salmonella NNP cord-023095-4dannjjm 842 9 is be VBZ cord-023095-4dannjjm 842 10 in in IN cord-023095-4dannjjm 842 11 agreement agreement NN cord-023095-4dannjjm 842 12 with with IN cord-023095-4dannjjm 842 13 some some DT cord-023095-4dannjjm 842 14 other other JJ cord-023095-4dannjjm 842 15 studies study NNS cord-023095-4dannjjm 842 16 . . . cord-023095-4dannjjm 843 1 The the DT cord-023095-4dannjjm 843 2 low low JJ cord-023095-4dannjjm 843 3 prevalence prevalence NN cord-023095-4dannjjm 843 4 of of IN cord-023095-4dannjjm 843 5 antibiotic antibiotic JJ cord-023095-4dannjjm 843 6 resistance resistance NN cord-023095-4dannjjm 843 7 in in IN cord-023095-4dannjjm 843 8 commensal commensal JJ cord-023095-4dannjjm 843 9 E. E. NNP cord-023095-4dannjjm 843 10 coli coli NNS cord-023095-4dannjjm 843 11 was be VBD cord-023095-4dannjjm 843 12 encouraging encouraging JJ cord-023095-4dannjjm 843 13 and and CC cord-023095-4dannjjm 843 14 suggests suggest VBZ cord-023095-4dannjjm 843 15 that that IN cord-023095-4dannjjm 843 16 healthy healthy JJ cord-023095-4dannjjm 843 17 horses horse NNS cord-023095-4dannjjm 843 18 on on IN cord-023095-4dannjjm 843 19 pleasure pleasure NN cord-023095-4dannjjm 843 20 horse horse NN cord-023095-4dannjjm 843 21 farms farm NNS cord-023095-4dannjjm 843 22 are be VBP cord-023095-4dannjjm 843 23 not not RB cord-023095-4dannjjm 843 24 likely likely RB cord-023095-4dannjjm 843 25 a a DT cord-023095-4dannjjm 843 26 major major JJ cord-023095-4dannjjm 843 27 reservoir reservoir NN cord-023095-4dannjjm 843 28 of of IN cord-023095-4dannjjm 843 29 resistance resistance NN cord-023095-4dannjjm 843 30 in in IN cord-023095-4dannjjm 843 31 enteric enteric JJ cord-023095-4dannjjm 843 32 bacteria bacteria NNS cord-023095-4dannjjm 843 33 . . . cord-023095-4dannjjm 844 1 Type type NN cord-023095-4dannjjm 844 2 1 1 CD cord-023095-4dannjjm 844 3 Polysaccharide polysaccharide NN cord-023095-4dannjjm 844 4 Storage Storage NNP cord-023095-4dannjjm 844 5 Myopathy Myopathy NNP cord-023095-4dannjjm 844 6 ( ( -LRB- cord-023095-4dannjjm 844 7 PSSM PSSM NNP cord-023095-4dannjjm 844 8 ) ) -RRB- cord-023095-4dannjjm 844 9 in in IN cord-023095-4dannjjm 844 10 horses horse NNS cord-023095-4dannjjm 844 11 is be VBZ cord-023095-4dannjjm 844 12 associated associate VBN cord-023095-4dannjjm 844 13 with with IN cord-023095-4dannjjm 844 14 a a DT cord-023095-4dannjjm 844 15 dominant dominant JJ cord-023095-4dannjjm 844 16 missense missense NN cord-023095-4dannjjm 844 17 mutation mutation NN cord-023095-4dannjjm 844 18 ( ( -LRB- cord-023095-4dannjjm 844 19 R309H R309H NNP cord-023095-4dannjjm 844 20 ) ) -RRB- cord-023095-4dannjjm 844 21 in in IN cord-023095-4dannjjm 844 22 the the DT cord-023095-4dannjjm 844 23 skeletal skeletal JJ cord-023095-4dannjjm 844 24 muscle muscle NN cord-023095-4dannjjm 844 25 glycogen glycogen NN cord-023095-4dannjjm 844 26 synthase synthase NN cord-023095-4dannjjm 844 27 gene gene NN cord-023095-4dannjjm 844 28 ( ( -LRB- cord-023095-4dannjjm 844 29 GYS1 GYS1 NNP cord-023095-4dannjjm 844 30 ) ) -RRB- cord-023095-4dannjjm 844 31 . . . cord-023095-4dannjjm 845 1 Since since IN cord-023095-4dannjjm 845 2 disease disease NN cord-023095-4dannjjm 845 3 severity severity NN cord-023095-4dannjjm 845 4 varies vary VBZ cord-023095-4dannjjm 845 5 between between IN cord-023095-4dannjjm 845 6 affected affected JJ cord-023095-4dannjjm 845 7 horses horse NNS cord-023095-4dannjjm 845 8 , , , cord-023095-4dannjjm 845 9 we -PRON- PRP cord-023095-4dannjjm 845 10 hypothesised hypothesise VBD cord-023095-4dannjjm 845 11 that that IN cord-023095-4dannjjm 845 12 some some DT cord-023095-4dannjjm 845 13 clinical clinical JJ cord-023095-4dannjjm 845 14 variability variability NN cord-023095-4dannjjm 845 15 could could MD cord-023095-4dannjjm 845 16 be be VB cord-023095-4dannjjm 845 17 accounted account VBN cord-023095-4dannjjm 845 18 for for IN cord-023095-4dannjjm 845 19 by by IN cord-023095-4dannjjm 845 20 the the DT cord-023095-4dannjjm 845 21 underlying underlie VBG cord-023095-4dannjjm 845 22 genotype genotype NN cord-023095-4dannjjm 845 23 . . . cord-023095-4dannjjm 846 1 107 107 CD cord-023095-4dannjjm 846 2 Belgian belgian JJ cord-023095-4dannjjm 846 3 / / SYM cord-023095-4dannjjm 846 4 Percheron Percheron NNP cord-023095-4dannjjm 846 5 horses horse NNS cord-023095-4dannjjm 846 6 were be VBD cord-023095-4dannjjm 846 7 genotyped genotype VBN cord-023095-4dannjjm 846 8 using use VBG cord-023095-4dannjjm 846 9 a a DT cord-023095-4dannjjm 846 10 validated validate VBN cord-023095-4dannjjm 846 11 restriction restriction NN cord-023095-4dannjjm 846 12 fragment fragment NN cord-023095-4dannjjm 846 13 length length NN cord-023095-4dannjjm 846 14 polymorphism polymorphism NN cord-023095-4dannjjm 846 15 assay assay NN cord-023095-4dannjjm 846 16 enabling enable VBG cord-023095-4dannjjm 846 17 grouping grouping NN cord-023095-4dannjjm 846 18 of of IN cord-023095-4dannjjm 846 19 horses horse NNS cord-023095-4dannjjm 846 20 as as IN cord-023095-4dannjjm 846 21 homozygotes homozygote NNS cord-023095-4dannjjm 846 22 ( ( -LRB- cord-023095-4dannjjm 846 23 HH HH NNP cord-023095-4dannjjm 846 24 ) ) -RRB- cord-023095-4dannjjm 846 25 , , , cord-023095-4dannjjm 846 26 heterozygotes(HR heterozygotes(hr ADD cord-023095-4dannjjm 846 27 ) ) -RRB- cord-023095-4dannjjm 846 28 or or CC cord-023095-4dannjjm 846 29 normal normal JJ cord-023095-4dannjjm 846 30 ( ( -LRB- cord-023095-4dannjjm 846 31 RR rr NN cord-023095-4dannjjm 846 32 ) ) -RRB- cord-023095-4dannjjm 846 33 . . . cord-023095-4dannjjm 847 1 Subsequently subsequently RB cord-023095-4dannjjm 847 2 , , , cord-023095-4dannjjm 847 3 semimembranosis semimembranosis NN cord-023095-4dannjjm 847 4 muscle muscle NN cord-023095-4dannjjm 847 5 samples sample NNS cord-023095-4dannjjm 847 6 were be VBD cord-023095-4dannjjm 847 7 biopsied biopsie VBN cord-023095-4dannjjm 847 8 from from IN cord-023095-4dannjjm 847 9 each each DT cord-023095-4dannjjm 847 10 of of IN cord-023095-4dannjjm 847 11 six six CD cord-023095-4dannjjm 847 12 matched match VBN cord-023095-4dannjjm 847 13 sedentary sedentary JJ cord-023095-4dannjjm 847 14 horses horse NNS cord-023095-4dannjjm 847 15 from from IN cord-023095-4dannjjm 847 16 each each DT cord-023095-4dannjjm 847 17 group group NN cord-023095-4dannjjm 847 18 ; ; : cord-023095-4dannjjm 847 19 one one CD cord-023095-4dannjjm 847 20 sample sample NN cord-023095-4dannjjm 847 21 was be VBD cord-023095-4dannjjm 847 22 formalin formalin NN cord-023095-4dannjjm 847 23 - - HYPH cord-023095-4dannjjm 847 24 fixed fix VBN cord-023095-4dannjjm 847 25 and and CC cord-023095-4dannjjm 847 26 one one CD cord-023095-4dannjjm 847 27 fresh fresh JJ cord-023095-4dannjjm 847 28 frozen frozen JJ cord-023095-4dannjjm 847 29 . . . cord-023095-4dannjjm 848 1 Sections section NNS cord-023095-4dannjjm 848 2 were be VBD cord-023095-4dannjjm 848 3 stained stain VBN cord-023095-4dannjjm 848 4 using use VBG cord-023095-4dannjjm 848 5 haematoxylin haematoxylin NNP cord-023095-4dannjjm 848 6 and and CC cord-023095-4dannjjm 848 7 eosin eosin NNP cord-023095-4dannjjm 848 8 , , , cord-023095-4dannjjm 848 9 periodic periodic JJ cord-023095-4dannjjm 848 10 acid acid NN cord-023095-4dannjjm 848 11 schiff schiff NNP cord-023095-4dannjjm 848 12 1 1 CD cord-023095-4dannjjm 849 1 /diastase /diastase . cord-023095-4dannjjm 849 2 . . . cord-023095-4dannjjm 850 1 Anti anti JJ cord-023095-4dannjjm 850 2 - - JJ cord-023095-4dannjjm 850 3 dystrophin dystrophin JJ cord-023095-4dannjjm 850 4 , , , cord-023095-4dannjjm 850 5 nNOS nNOS NNP cord-023095-4dannjjm 850 6 and and CC cord-023095-4dannjjm 850 7 myosin myosin NN cord-023095-4dannjjm 850 8 heavy heavy JJ cord-023095-4dannjjm 850 9 chain chain NN cord-023095-4dannjjm 850 10 immunohistochemistry immunohistochemistry NN cord-023095-4dannjjm 850 11 was be VBD cord-023095-4dannjjm 850 12 performed perform VBN cord-023095-4dannjjm 850 13 to to TO cord-023095-4dannjjm 850 14 examine examine VB cord-023095-4dannjjm 850 15 sarcolemmal sarcolemmal NNP cord-023095-4dannjjm 850 16 intregrity intregrity NN cord-023095-4dannjjm 850 17 , , , cord-023095-4dannjjm 850 18 There there EX cord-023095-4dannjjm 850 19 were be VBD cord-023095-4dannjjm 850 20 significant significant JJ cord-023095-4dannjjm 850 21 differences difference NNS cord-023095-4dannjjm 850 22 in in IN cord-023095-4dannjjm 850 23 resting rest VBG cord-023095-4dannjjm 850 24 CK CK NNP cord-023095-4dannjjm 850 25 activity activity NN cord-023095-4dannjjm 850 26 ( ( -LRB- cord-023095-4dannjjm 850 27 P p NN cord-023095-4dannjjm 850 28 5 5 CD cord-023095-4dannjjm 850 29 0.023 0.023 CD cord-023095-4dannjjm 850 30 ) ) -RRB- cord-023095-4dannjjm 851 1 ( ( -LRB- cord-023095-4dannjjm 851 2 median median JJ cord-023095-4dannjjm 851 3 HH HH NNP cord-023095-4dannjjm 851 4 5 5 CD cord-023095-4dannjjm 851 5 364U 364u CD cord-023095-4dannjjm 852 1 /l /l NFP cord-023095-4dannjjm 852 2 interquartile interquartile JJ cord-023095-4dannjjm 852 3 range(IR range(IR NNS cord-023095-4dannjjm 852 4 ) ) -RRB- cord-023095-4dannjjm 853 1 332 332 CD cord-023095-4dannjjm 853 2 - - SYM cord-023095-4dannjjm 853 3 764 764 CD cord-023095-4dannjjm 853 4 ; ; . cord-023095-4dannjjm 854 1 HR HR NNP cord-023095-4dannjjm 854 2 5 5 CD cord-023095-4dannjjm 854 3 301U/ 301u/ CD cord-023095-4dannjjm 855 1 l l NNP cord-023095-4dannjjm 855 2 IR222 ir222 NN cord-023095-4dannjjm 855 3 - - HYPH cord-023095-4dannjjm 855 4 377 377 CD cord-023095-4dannjjm 855 5 ; ; : cord-023095-4dannjjm 855 6 RR RR NNP cord-023095-4dannjjm 855 7 5 5 CD cord-023095-4dannjjm 855 8 260U 260u CD cord-023095-4dannjjm 855 9 / / SYM cord-023095-4dannjjm 855 10 l l NNP cord-023095-4dannjjm 855 11 IR216 IR216 NNP cord-023095-4dannjjm 855 12 - - HYPH cord-023095-4dannjjm 855 13 320 320 CD cord-023095-4dannjjm 855 14 ) ) -RRB- cord-023095-4dannjjm 855 15 and and CC cord-023095-4dannjjm 855 16 AST ast NN cord-023095-4dannjjm 855 17 activity activity NN cord-023095-4dannjjm 856 1 ( ( -LRB- cord-023095-4dannjjm 856 2 P p NN cord-023095-4dannjjm 856 3 o o NN cord-023095-4dannjjm 856 4 0.001 0.001 CD cord-023095-4dannjjm 856 5 ) ) -RRB- cord-023095-4dannjjm 857 1 ( ( -LRB- cord-023095-4dannjjm 857 2 AST AST NNP cord-023095-4dannjjm 857 3 mean mean VBP cord-023095-4dannjjm 857 4 HH HH NNP cord-023095-4dannjjm 857 5 5 5 CD cord-023095-4dannjjm 858 1 502U 502u CD cord-023095-4dannjjm 859 1 /l /l NNP cord-023095-4dannjjm 859 2 SD116 SD116 NNP cord-023095-4dannjjm 860 1 ; ; : cord-023095-4dannjjm 860 2 HR HR NNP cord-023095-4dannjjm 860 3 5 5 CD cord-023095-4dannjjm 860 4 357U 357U NNP cord-023095-4dannjjm 860 5 / / SYM cord-023095-4dannjjm 860 6 l l NNP cord-023095-4dannjjm 860 7 SD92 SD92 NNP cord-023095-4dannjjm 860 8 ; ; : cord-023095-4dannjjm 860 9 RR RR NNP cord-023095-4dannjjm 860 10 5 5 CD cord-023095-4dannjjm 860 11 311U 311u CD cord-023095-4dannjjm 860 12 / / SYM cord-023095-4dannjjm 860 13 l l NNP cord-023095-4dannjjm 860 14 SD64 SD64 NNP cord-023095-4dannjjm 860 15 ) ) -RRB- cord-023095-4dannjjm 860 16 and and CC cord-023095-4dannjjm 860 17 muscle muscle NN cord-023095-4dannjjm 860 18 pathology pathology NN cord-023095-4dannjjm 860 19 between between IN cord-023095-4dannjjm 860 20 the the DT cord-023095-4dannjjm 860 21 3 3 CD cord-023095-4dannjjm 860 22 groups group NNS cord-023095-4dannjjm 860 23 , , , cord-023095-4dannjjm 860 24 with with IN cord-023095-4dannjjm 860 25 severity severity NN cord-023095-4dannjjm 860 26 increasing increase VBG cord-023095-4dannjjm 860 27 RR rr NN cord-023095-4dannjjm 860 28 o o NN cord-023095-4dannjjm 860 29 HR hr NN cord-023095-4dannjjm 860 30 o o NN cord-023095-4dannjjm 860 31 HH hh NN cord-023095-4dannjjm 860 32 . . . cord-023095-4dannjjm 861 1 There there EX cord-023095-4dannjjm 861 2 were be VBD cord-023095-4dannjjm 861 3 significantly significantly RB cord-023095-4dannjjm 861 4 more more JJR cord-023095-4dannjjm 861 5 type type NN cord-023095-4dannjjm 861 6 2a 2a CD cord-023095-4dannjjm 861 7 ( ( -LRB- cord-023095-4dannjjm 861 8 P p NN cord-023095-4dannjjm 861 9 5 5 CD cord-023095-4dannjjm 861 10 0.04 0.04 CD cord-023095-4dannjjm 861 11 ) ) -RRB- cord-023095-4dannjjm 861 12 and and CC cord-023095-4dannjjm 861 13 fewer few JJR cord-023095-4dannjjm 861 14 type type NN cord-023095-4dannjjm 861 15 2x 2x CD cord-023095-4dannjjm 861 16 fibres fibre NNS cord-023095-4dannjjm 861 17 ( ( -LRB- cord-023095-4dannjjm 861 18 P p NN cord-023095-4dannjjm 861 19 5 5 CD cord-023095-4dannjjm 861 20 0.02 0.02 CD cord-023095-4dannjjm 861 21 ) ) -RRB- cord-023095-4dannjjm 861 22 in in IN cord-023095-4dannjjm 861 23 homozygotes homozygote NNS cord-023095-4dannjjm 861 24 ( ( -LRB- cord-023095-4dannjjm 861 25 2a 2a CD cord-023095-4dannjjm 861 26 55 55 CD cord-023095-4dannjjm 861 27 % % NN cord-023095-4dannjjm 861 28 SD sd NN cord-023095-4dannjjm 861 29 10.2 10.2 CD cord-023095-4dannjjm 861 30 ; ; : cord-023095-4dannjjm 861 31 2x 2x CD cord-023095-4dannjjm 861 32 32 32 CD cord-023095-4dannjjm 861 33 % % NN cord-023095-4dannjjm 861 34 SD SD NNP cord-023095-4dannjjm 861 35 18 18 CD cord-023095-4dannjjm 861 36 ) ) -RRB- cord-023095-4dannjjm 861 37 compared compare VBN cord-023095-4dannjjm 861 38 with with IN cord-023095-4dannjjm 861 39 the the DT cord-023095-4dannjjm 861 40 other other JJ cord-023095-4dannjjm 861 41 groups group NNS cord-023095-4dannjjm 861 42 ( ( -LRB- cord-023095-4dannjjm 861 43 HR HR NNP cord-023095-4dannjjm 861 44 2a 2a CD cord-023095-4dannjjm 861 45 38 38 CD cord-023095-4dannjjm 861 46 % % NN cord-023095-4dannjjm 861 47 SD SD NNP cord-023095-4dannjjm 861 48 10.9 10.9 CD cord-023095-4dannjjm 861 49 , , , cord-023095-4dannjjm 861 50 2x 2x CD cord-023095-4dannjjm 861 51 44 44 CD cord-023095-4dannjjm 861 52 % % NN cord-023095-4dannjjm 861 53 SD sd NN cord-023095-4dannjjm 861 54 10.8 10.8 CD cord-023095-4dannjjm 861 55 ; ; : cord-023095-4dannjjm 861 56 RR rr NN cord-023095-4dannjjm 861 57 : : : cord-023095-4dannjjm 862 1 2a 2a CD cord-023095-4dannjjm 862 2 36.5 36.5 CD cord-023095-4dannjjm 862 3 % % NN cord-023095-4dannjjm 862 4 SD SD NNP cord-023095-4dannjjm 862 5 12.4 12.4 CD cord-023095-4dannjjm 862 6 2x 2x CD cord-023095-4dannjjm 862 7 57 57 CD cord-023095-4dannjjm 862 8 % % NN cord-023095-4dannjjm 862 9 SD sd NN cord-023095-4dannjjm 862 10 11.5 11.5 CD cord-023095-4dannjjm 862 11 ) ) -RRB- cord-023095-4dannjjm 862 12 . . . cord-023095-4dannjjm 863 1 More More JJR cord-023095-4dannjjm 863 2 type type NN cord-023095-4dannjjm 863 3 2a 2a CD cord-023095-4dannjjm 863 4 fibres fibre NNS cord-023095-4dannjjm 863 5 contained contain VBD cord-023095-4dannjjm 863 6 polysaccharide polysaccharide NN cord-023095-4dannjjm 863 7 inclusions inclusion NNS cord-023095-4dannjjm 863 8 in in IN cord-023095-4dannjjm 863 9 homozygotes homozygote NNS cord-023095-4dannjjm 863 10 ( ( -LRB- cord-023095-4dannjjm 863 11 30 30 CD cord-023095-4dannjjm 863 12 % % NN cord-023095-4dannjjm 863 13 SD sd NN cord-023095-4dannjjm 863 14 11.1 11.1 CD cord-023095-4dannjjm 863 15 ) ) -RRB- cord-023095-4dannjjm 863 16 than than IN cord-023095-4dannjjm 863 17 in in IN cord-023095-4dannjjm 863 18 heterozygotes heterozygote NNS cord-023095-4dannjjm 863 19 ( ( -LRB- cord-023095-4dannjjm 863 20 10.6 10.6 CD cord-023095-4dannjjm 863 21 % % NN cord-023095-4dannjjm 863 22 SD sd NN cord-023095-4dannjjm 863 23 6.9 6.9 CD cord-023095-4dannjjm 863 24 ) ) -RRB- cord-023095-4dannjjm 864 1 ( ( -LRB- cord-023095-4dannjjm 864 2 P p NN cord-023095-4dannjjm 864 3 o o NN cord-023095-4dannjjm 864 4 0.001 0.001 CD cord-023095-4dannjjm 864 5 ) ) -RRB- cord-023095-4dannjjm 864 6 . . . cord-023095-4dannjjm 865 1 Both both DT cord-023095-4dannjjm 865 2 dystrophin dystrophin NN cord-023095-4dannjjm 865 3 and and CC cord-023095-4dannjjm 865 4 nNOS nnos JJ cord-023095-4dannjjm 865 5 expression expression NN cord-023095-4dannjjm 865 6 was be VBD cord-023095-4dannjjm 865 7 normally normally RB cord-023095-4dannjjm 865 8 localised localised JJ cord-023095-4dannjjm 865 9 to to IN cord-023095-4dannjjm 865 10 the the DT cord-023095-4dannjjm 865 11 sarcolemma sarcolemma NN cord-023095-4dannjjm 865 12 in in IN cord-023095-4dannjjm 865 13 pathologically pathologically RB cord-023095-4dannjjm 865 14 normal normal JJ cord-023095-4dannjjm 865 15 and and CC cord-023095-4dannjjm 865 16 vacuolated vacuolated JJ cord-023095-4dannjjm 865 17 fibres fibre NNS cord-023095-4dannjjm 865 18 from from IN cord-023095-4dannjjm 865 19 mutant mutant JJ cord-023095-4dannjjm 865 20 horses horse NNS cord-023095-4dannjjm 865 21 . . . cord-023095-4dannjjm 866 1 In in IN cord-023095-4dannjjm 866 2 conclusion conclusion NN cord-023095-4dannjjm 866 3 , , , cord-023095-4dannjjm 866 4 sedentary sedentary JJ cord-023095-4dannjjm 866 5 homozygotes homozygote NNS cord-023095-4dannjjm 866 6 have have VBP cord-023095-4dannjjm 866 7 more more RBR cord-023095-4dannjjm 866 8 severe severe JJ cord-023095-4dannjjm 866 9 skeletal skeletal JJ cord-023095-4dannjjm 866 10 muscle muscle NN cord-023095-4dannjjm 866 11 pathology pathology NN cord-023095-4dannjjm 866 12 and and CC cord-023095-4dannjjm 866 13 higher high JJR cord-023095-4dannjjm 866 14 resting rest VBG cord-023095-4dannjjm 866 15 plasma plasma NN cord-023095-4dannjjm 866 16 CK CK NNP cord-023095-4dannjjm 866 17 and and CC cord-023095-4dannjjm 866 18 AST AST NNP cord-023095-4dannjjm 866 19 activities activity NNS cord-023095-4dannjjm 866 20 than than IN cord-023095-4dannjjm 866 21 heterozygotes heterozygote NNS cord-023095-4dannjjm 866 22 , , , cord-023095-4dannjjm 866 23 and and CC cord-023095-4dannjjm 866 24 PSSM1 pssm1 NN cord-023095-4dannjjm 866 25 is be VBZ cord-023095-4dannjjm 866 26 associated associate VBN cord-023095-4dannjjm 866 27 with with IN cord-023095-4dannjjm 866 28 a a DT cord-023095-4dannjjm 866 29 fibre fibre NN cord-023095-4dannjjm 866 30 type type NN cord-023095-4dannjjm 866 31 shift shift NN cord-023095-4dannjjm 866 32 towards towards IN cord-023095-4dannjjm 866 33 type type NN cord-023095-4dannjjm 866 34 2a 2a CD cord-023095-4dannjjm 866 35 . . . cord-023095-4dannjjm 867 1 Although although IN cord-023095-4dannjjm 867 2 subsarcolemmal subsarcolemmal JJ cord-023095-4dannjjm 867 3 vacuolation vacuolation NN cord-023095-4dannjjm 867 4 likely likely RB cord-023095-4dannjjm 867 5 disrupts disrupt VBZ cord-023095-4dannjjm 867 6 the the DT cord-023095-4dannjjm 867 7 contractile contractile JJ cord-023095-4dannjjm 867 8 apparatus apparatus NN cord-023095-4dannjjm 867 9 's 's POS cord-023095-4dannjjm 867 10 attachment attachment NN cord-023095-4dannjjm 867 11 to to IN cord-023095-4dannjjm 867 12 the the DT cord-023095-4dannjjm 867 13 sarcolemma sarcolemma NNP cord-023095-4dannjjm 867 14 , , , cord-023095-4dannjjm 867 15 the the DT cord-023095-4dannjjm 867 16 latter latter NN cord-023095-4dannjjm 867 17 's 's POS cord-023095-4dannjjm 867 18 integrity integrity NN cord-023095-4dannjjm 867 19 appeared appear VBD cord-023095-4dannjjm 867 20 intact intact JJ cord-023095-4dannjjm 867 21 . . . cord-023095-4dannjjm 868 1 The the DT cord-023095-4dannjjm 868 2 recumbent recumbent JJ cord-023095-4dannjjm 868 3 horse horse NN cord-023095-4dannjjm 868 4 presents present VBZ cord-023095-4dannjjm 868 5 a a DT cord-023095-4dannjjm 868 6 logistic logistic JJ cord-023095-4dannjjm 868 7 , , , cord-023095-4dannjjm 868 8 diagnostic diagnostic JJ cord-023095-4dannjjm 868 9 , , , cord-023095-4dannjjm 868 10 and and CC cord-023095-4dannjjm 868 11 therapeutic therapeutic JJ cord-023095-4dannjjm 868 12 challenge challenge NN cord-023095-4dannjjm 868 13 to to IN cord-023095-4dannjjm 868 14 the the DT cord-023095-4dannjjm 868 15 equine equine JJ cord-023095-4dannjjm 868 16 practitioner practitioner NN cord-023095-4dannjjm 868 17 . . . cord-023095-4dannjjm 869 1 There there EX cord-023095-4dannjjm 869 2 is be VBZ cord-023095-4dannjjm 869 3 currently currently RB cord-023095-4dannjjm 869 4 very very RB cord-023095-4dannjjm 869 5 little little JJ cord-023095-4dannjjm 869 6 data datum NNS cord-023095-4dannjjm 869 7 available available JJ cord-023095-4dannjjm 869 8 on on IN cord-023095-4dannjjm 869 9 the the DT cord-023095-4dannjjm 869 10 prognosis prognosis NN cord-023095-4dannjjm 869 11 and and CC cord-023095-4dannjjm 869 12 outcome outcome NN cord-023095-4dannjjm 869 13 of of IN cord-023095-4dannjjm 869 14 horses horse NNS cord-023095-4dannjjm 869 15 that that WDT cord-023095-4dannjjm 869 16 are be VBP cord-023095-4dannjjm 869 17 recumbent recumbent JJ cord-023095-4dannjjm 869 18 . . . cord-023095-4dannjjm 870 1 Therefore therefore RB cord-023095-4dannjjm 870 2 , , , cord-023095-4dannjjm 870 3 the the DT cord-023095-4dannjjm 870 4 purpose purpose NN cord-023095-4dannjjm 870 5 of of IN cord-023095-4dannjjm 870 6 this this DT cord-023095-4dannjjm 870 7 study study NN cord-023095-4dannjjm 870 8 was be VBD cord-023095-4dannjjm 870 9 to to TO cord-023095-4dannjjm 870 10 investigate investigate VB cord-023095-4dannjjm 870 11 the the DT cord-023095-4dannjjm 870 12 outcome outcome NN cord-023095-4dannjjm 870 13 of of IN cord-023095-4dannjjm 870 14 hospitalized hospitalize VBN cord-023095-4dannjjm 870 15 horses horse NNS cord-023095-4dannjjm 870 16 that that WDT cord-023095-4dannjjm 870 17 had have VBD cord-023095-4dannjjm 870 18 been be VBN cord-023095-4dannjjm 870 19 recumbent recumbent JJ cord-023095-4dannjjm 870 20 in in IN cord-023095-4dannjjm 870 21 the the DT cord-023095-4dannjjm 870 22 field field NN cord-023095-4dannjjm 870 23 or or CC cord-023095-4dannjjm 870 24 in in IN cord-023095-4dannjjm 870 25 the the DT cord-023095-4dannjjm 870 26 hospital hospital NN cord-023095-4dannjjm 870 27 and and CC cord-023095-4dannjjm 870 28 the the DT cord-023095-4dannjjm 870 29 factors factor NNS cord-023095-4dannjjm 870 30 affecting affect VBG cord-023095-4dannjjm 870 31 their -PRON- PRP$ cord-023095-4dannjjm 870 32 survival survival NN cord-023095-4dannjjm 870 33 . . . cord-023095-4dannjjm 871 1 Records record NNS cord-023095-4dannjjm 871 2 of of IN cord-023095-4dannjjm 871 3 horses horse NNS cord-023095-4dannjjm 871 4 admitted admit VBN cord-023095-4dannjjm 871 5 to to IN cord-023095-4dannjjm 871 6 the the DT cord-023095-4dannjjm 871 7 School School NNP cord-023095-4dannjjm 871 8 of of IN cord-023095-4dannjjm 871 9 Veterinary Veterinary NNP cord-023095-4dannjjm 871 10 Medicine Medicine NNP cord-023095-4dannjjm 871 11 , , , cord-023095-4dannjjm 871 12 University University NNP cord-023095-4dannjjm 871 13 of of IN cord-023095-4dannjjm 871 14 California California NNP cord-023095-4dannjjm 871 15 Davis Davis NNP cord-023095-4dannjjm 871 16 from from IN cord-023095-4dannjjm 871 17 January January NNP cord-023095-4dannjjm 871 18 of of IN cord-023095-4dannjjm 871 19 1995 1995 CD cord-023095-4dannjjm 871 20 to to IN cord-023095-4dannjjm 871 21 December December NNP cord-023095-4dannjjm 871 22 of of IN cord-023095-4dannjjm 871 23 2010 2010 CD cord-023095-4dannjjm 871 24 with with IN cord-023095-4dannjjm 871 25 a a DT cord-023095-4dannjjm 871 26 history history NN cord-023095-4dannjjm 871 27 of of IN cord-023095-4dannjjm 871 28 recumbency recumbency NN cord-023095-4dannjjm 871 29 or or CC cord-023095-4dannjjm 871 30 horses horse NNS cord-023095-4dannjjm 871 31 that that WDT cord-023095-4dannjjm 871 32 became become VBD cord-023095-4dannjjm 871 33 recumbent recumbent JJ cord-023095-4dannjjm 871 34 while while IN cord-023095-4dannjjm 871 35 hospitalized hospitalize VBN cord-023095-4dannjjm 871 36 were be VBD cord-023095-4dannjjm 871 37 evaluated evaluate VBN cord-023095-4dannjjm 871 38 . . . cord-023095-4dannjjm 872 1 A a DT cord-023095-4dannjjm 872 2 horse horse NN cord-023095-4dannjjm 872 3 was be VBD cord-023095-4dannjjm 872 4 defined define VBN cord-023095-4dannjjm 872 5 as as IN cord-023095-4dannjjm 872 6 recumbent recumbent JJ cord-023095-4dannjjm 872 7 if if IN cord-023095-4dannjjm 872 8 it -PRON- PRP cord-023095-4dannjjm 872 9 was be VBD cord-023095-4dannjjm 872 10 unable unable JJ cord-023095-4dannjjm 872 11 to to TO cord-023095-4dannjjm 872 12 stand stand VB cord-023095-4dannjjm 872 13 on on IN cord-023095-4dannjjm 872 14 its -PRON- PRP$ cord-023095-4dannjjm 872 15 own own JJ cord-023095-4dannjjm 872 16 . . . cord-023095-4dannjjm 873 1 The the DT cord-023095-4dannjjm 873 2 medical medical JJ cord-023095-4dannjjm 873 3 record record NN cord-023095-4dannjjm 873 4 was be VBD cord-023095-4dannjjm 873 5 examined examine VBN cord-023095-4dannjjm 873 6 for for IN cord-023095-4dannjjm 873 7 the the DT cord-023095-4dannjjm 873 8 following follow VBG cord-023095-4dannjjm 873 9 criteria criterion NNS cord-023095-4dannjjm 873 10 : : : cord-023095-4dannjjm 873 11 history history NN cord-023095-4dannjjm 873 12 pertaining pertain VBG cord-023095-4dannjjm 873 13 to to IN cord-023095-4dannjjm 873 14 the the DT cord-023095-4dannjjm 873 15 current current JJ cord-023095-4dannjjm 873 16 illness illness NN cord-023095-4dannjjm 873 17 including include VBG cord-023095-4dannjjm 873 18 treatment treatment NN cord-023095-4dannjjm 873 19 by by IN cord-023095-4dannjjm 873 20 the the DT cord-023095-4dannjjm 873 21 rDVM rdvm NN cord-023095-4dannjjm 873 22 , , , cord-023095-4dannjjm 873 23 breed breed NN cord-023095-4dannjjm 873 24 , , , cord-023095-4dannjjm 873 25 age age NN cord-023095-4dannjjm 873 26 , , , cord-023095-4dannjjm 873 27 weight weight NN cord-023095-4dannjjm 873 28 , , , cord-023095-4dannjjm 873 29 date date NN cord-023095-4dannjjm 873 30 of of IN cord-023095-4dannjjm 873 31 presentation presentation NN cord-023095-4dannjjm 873 32 , , , cord-023095-4dannjjm 873 33 physical physical JJ cord-023095-4dannjjm 873 34 and and CC cord-023095-4dannjjm 873 35 neurological neurological JJ cord-023095-4dannjjm 873 36 examination examination NN cord-023095-4dannjjm 873 37 findings finding NNS cord-023095-4dannjjm 873 38 , , , cord-023095-4dannjjm 873 39 CBC CBC NNP cord-023095-4dannjjm 873 40 and and CC cord-023095-4dannjjm 873 41 biochemical biochemical JJ cord-023095-4dannjjm 873 42 profile profile NN cord-023095-4dannjjm 873 43 results result NNS cord-023095-4dannjjm 873 44 , , , cord-023095-4dannjjm 873 45 initial initial JJ cord-023095-4dannjjm 873 46 drugs drug NNS cord-023095-4dannjjm 873 47 administered administer VBN cord-023095-4dannjjm 873 48 on on IN cord-023095-4dannjjm 873 49 arrival arrival NN cord-023095-4dannjjm 873 50 , , , cord-023095-4dannjjm 873 51 time time NN cord-023095-4dannjjm 873 52 spent spend VBD cord-023095-4dannjjm 873 53 recumbent recumbent JJ cord-023095-4dannjjm 873 54 , , , cord-023095-4dannjjm 873 55 time time NN cord-023095-4dannjjm 873 56 spent spend VBN cord-023095-4dannjjm 873 57 in in IN cord-023095-4dannjjm 873 58 a a DT cord-023095-4dannjjm 873 59 sling sling NN cord-023095-4dannjjm 873 60 , , , cord-023095-4dannjjm 873 61 diagnosis diagnosis NN cord-023095-4dannjjm 873 62 , , , cord-023095-4dannjjm 873 63 and and CC cord-023095-4dannjjm 873 64 hospitalization hospitalization NN cord-023095-4dannjjm 873 65 costs cost NNS cord-023095-4dannjjm 873 66 . . . cord-023095-4dannjjm 874 1 Statistical statistical JJ cord-023095-4dannjjm 874 2 analysis analysis NN cord-023095-4dannjjm 874 3 correlating correlate VBG cord-023095-4dannjjm 874 4 factors factor NNS cord-023095-4dannjjm 874 5 associated associate VBN cord-023095-4dannjjm 874 6 with with IN cord-023095-4dannjjm 874 7 survival survival NN cord-023095-4dannjjm 874 8 was be VBD cord-023095-4dannjjm 874 9 performed perform VBN cord-023095-4dannjjm 874 10 using use VBG cord-023095-4dannjjm 874 11 logistic logistic JJ cord-023095-4dannjjm 874 12 regression regression NN cord-023095-4dannjjm 874 13 . . . cord-023095-4dannjjm 875 1 Overall overall RB cord-023095-4dannjjm 875 2 there there EX cord-023095-4dannjjm 875 3 were be VBD cord-023095-4dannjjm 875 4 112 112 CD cord-023095-4dannjjm 875 5 non non JJ cord-023095-4dannjjm 875 6 survivors survivor NNS cord-023095-4dannjjm 875 7 and and CC cord-023095-4dannjjm 875 8 49 49 CD cord-023095-4dannjjm 875 9 survivors survivor NNS cord-023095-4dannjjm 875 10 . . . cord-023095-4dannjjm 876 1 Factors factor NNS cord-023095-4dannjjm 876 2 that that WDT cord-023095-4dannjjm 876 3 favored favor VBD cord-023095-4dannjjm 876 4 survival survival NN cord-023095-4dannjjm 876 5 included include VBD cord-023095-4dannjjm 876 6 early early JJ cord-023095-4dannjjm 876 7 initiation initiation NN cord-023095-4dannjjm 876 8 of of IN cord-023095-4dannjjm 876 9 treatment treatment NN cord-023095-4dannjjm 876 10 in in IN cord-023095-4dannjjm 876 11 the the DT cord-023095-4dannjjm 876 12 field field NN cord-023095-4dannjjm 876 13 by by IN cord-023095-4dannjjm 876 14 the the DT cord-023095-4dannjjm 876 15 rDVM rdvm NN cord-023095-4dannjjm 876 16 , , , cord-023095-4dannjjm 876 17 horses horse NNS cord-023095-4dannjjm 876 18 that that WDT cord-023095-4dannjjm 876 19 tolerated tolerate VBD cord-023095-4dannjjm 876 20 a a DT cord-023095-4dannjjm 876 21 sling sling NN cord-023095-4dannjjm 876 22 and and CC cord-023095-4dannjjm 876 23 spent spend VBD cord-023095-4dannjjm 876 24 more more JJR cord-023095-4dannjjm 876 25 time time NN cord-023095-4dannjjm 876 26 in in IN cord-023095-4dannjjm 876 27 a a DT cord-023095-4dannjjm 876 28 sling sling NN cord-023095-4dannjjm 876 29 , , , cord-023095-4dannjjm 876 30 increased increase VBN cord-023095-4dannjjm 876 31 duration duration NN cord-023095-4dannjjm 876 32 and and CC cord-023095-4dannjjm 876 33 costs cost NNS cord-023095-4dannjjm 876 34 of of IN cord-023095-4dannjjm 876 35 hospitalization hospitalization NN cord-023095-4dannjjm 876 36 , , , cord-023095-4dannjjm 876 37 horses horse NNS cord-023095-4dannjjm 876 38 that that WDT cord-023095-4dannjjm 876 39 were be VBD cord-023095-4dannjjm 876 40 recumbent recumbent JJ cord-023095-4dannjjm 876 41 post post NN cord-023095-4dannjjm 876 42 anesthesia anesthesia NN cord-023095-4dannjjm 876 43 , , , cord-023095-4dannjjm 876 44 and and CC cord-023095-4dannjjm 876 45 those those DT cord-023095-4dannjjm 876 46 recumbent recumbent JJ cord-023095-4dannjjm 876 47 due due IN cord-023095-4dannjjm 876 48 to to IN cord-023095-4dannjjm 876 49 disease disease NN cord-023095-4dannjjm 876 50 of of IN cord-023095-4dannjjm 876 51 the the DT cord-023095-4dannjjm 876 52 musculoskeletal musculoskeletal JJ cord-023095-4dannjjm 876 53 system system NN cord-023095-4dannjjm 876 54 . . . cord-023095-4dannjjm 877 1 Factors factor NNS cord-023095-4dannjjm 877 2 that that WDT cord-023095-4dannjjm 877 3 increased increase VBD cord-023095-4dannjjm 877 4 likelihood likelihood NN cord-023095-4dannjjm 877 5 of of IN cord-023095-4dannjjm 877 6 non non JJ cord-023095-4dannjjm 877 7 survival survival NN cord-023095-4dannjjm 877 8 included include VBD cord-023095-4dannjjm 877 9 horses horse NNS cord-023095-4dannjjm 877 10 that that WDT cord-023095-4dannjjm 877 11 were be VBD cord-023095-4dannjjm 877 12 ataxic ataxic JJ cord-023095-4dannjjm 877 13 on on IN cord-023095-4dannjjm 877 14 presentation presentation NN cord-023095-4dannjjm 877 15 , , , cord-023095-4dannjjm 877 16 horses horse NNS cord-023095-4dannjjm 877 17 with with IN cord-023095-4dannjjm 877 18 increased increase VBN cord-023095-4dannjjm 877 19 BUN bun NN cord-023095-4dannjjm 877 20 , , , cord-023095-4dannjjm 877 21 horses horse NNS cord-023095-4dannjjm 877 22 that that WDT cord-023095-4dannjjm 877 23 spent spend VBD cord-023095-4dannjjm 877 24 more more JJR cord-023095-4dannjjm 877 25 time time NN cord-023095-4dannjjm 877 26 recumbent recumbent NN cord-023095-4dannjjm 877 27 , , , cord-023095-4dannjjm 877 28 those those DT cord-023095-4dannjjm 877 29 that that WDT cord-023095-4dannjjm 877 30 did do VBD cord-023095-4dannjjm 877 31 not not RB cord-023095-4dannjjm 877 32 tolerate tolerate VB cord-023095-4dannjjm 877 33 a a DT cord-023095-4dannjjm 877 34 sling sling NN cord-023095-4dannjjm 877 35 , , , cord-023095-4dannjjm 877 36 and and CC cord-023095-4dannjjm 877 37 horses horse NNS cord-023095-4dannjjm 877 38 diagnosed diagnose VBN cord-023095-4dannjjm 877 39 with with IN cord-023095-4dannjjm 877 40 botulism botulism NN cord-023095-4dannjjm 877 41 and and CC cord-023095-4dannjjm 877 42 spinal spinal JJ cord-023095-4dannjjm 877 43 cord cord NN cord-023095-4dannjjm 877 44 disease disease NN cord-023095-4dannjjm 877 45 . . . cord-023095-4dannjjm 878 1 In in IN cord-023095-4dannjjm 878 2 conclusion conclusion NN cord-023095-4dannjjm 878 3 , , , cord-023095-4dannjjm 878 4 this this DT cord-023095-4dannjjm 878 5 retrospective retrospective JJ cord-023095-4dannjjm 878 6 study study NN cord-023095-4dannjjm 878 7 demonstrated demonstrate VBD cord-023095-4dannjjm 878 8 that that IN cord-023095-4dannjjm 878 9 both both CC cord-023095-4dannjjm 878 10 the the DT cord-023095-4dannjjm 878 11 cause cause NN cord-023095-4dannjjm 878 12 of of IN cord-023095-4dannjjm 878 13 recumbency recumbency NN cord-023095-4dannjjm 878 14 and and CC cord-023095-4dannjjm 878 15 the the DT cord-023095-4dannjjm 878 16 ability ability NN cord-023095-4dannjjm 878 17 of of IN cord-023095-4dannjjm 878 18 horses horse NNS cord-023095-4dannjjm 878 19 to to TO cord-023095-4dannjjm 878 20 tolerate tolerate VB cord-023095-4dannjjm 878 21 a a DT cord-023095-4dannjjm 878 22 sling sling NN cord-023095-4dannjjm 878 23 had have VBD cord-023095-4dannjjm 878 24 a a DT cord-023095-4dannjjm 878 25 direct direct JJ cord-023095-4dannjjm 878 26 effect effect NN cord-023095-4dannjjm 878 27 on on IN cord-023095-4dannjjm 878 28 survival survival NN cord-023095-4dannjjm 878 29 . . . cord-023095-4dannjjm 879 1 ABSTRACT ABSTRACT NNP cord-023095-4dannjjm 879 2 E-7 E-7 NNP cord-023095-4dannjjm 880 1 PLASMA plasma NN cord-023095-4dannjjm 880 2 PEAK peak NN cord-023095-4dannjjm 880 3 AND and CC cord-023095-4dannjjm 880 4 TROUGH trough NN cord-023095-4dannjjm 880 5 GENTAMICIN GENTAMICIN NNP cord-023095-4dannjjm 880 6 CONCENTRA CONCENTRA NNP cord-023095-4dannjjm 880 7 - - HYPH cord-023095-4dannjjm 880 8 TIONS TIONS NNP cord-023095-4dannjjm 881 1 IN in IN cord-023095-4dannjjm 881 2 HOSPITALIZED hospitalized JJ cord-023095-4dannjjm 881 3 HORSES horse NNS cord-023095-4dannjjm 881 4 RECEIVING receive VBG cord-023095-4dannjjm 881 5 ONCE once RB cord-023095-4dannjjm 881 6 DAILY daily JJ cord-023095-4dannjjm 881 7 GENTAMICIN gentamicin NN cord-023095-4dannjjm 881 8 . . . cord-023095-4dannjjm 882 1 JR JR NNP cord-023095-4dannjjm 882 2 Read Read NNP cord-023095-4dannjjm 882 3 1 1 CD cord-023095-4dannjjm 882 4 , , , cord-023095-4dannjjm 882 5 PA PA NNP cord-023095-4dannjjm 882 6 Wilkins Wilkins NNP cord-023095-4dannjjm 882 7 2 2 CD cord-023095-4dannjjm 882 8 , , , cord-023095-4dannjjm 882 9 RD RD NNP cord-023095-4dannjjm 882 10 Nolen Nolen NNP cord-023095-4dannjjm 882 11 - - HYPH cord-023095-4dannjjm 882 12 Walston Walston NNP cord-023095-4dannjjm 882 13 1 1 CD cord-023095-4dannjjm 882 14 . . . cord-023095-4dannjjm 883 1 1 1 CD cord-023095-4dannjjm 883 2 University University NNP cord-023095-4dannjjm 883 3 of of IN cord-023095-4dannjjm 883 4 Pennsylvania Pennsylvania NNP cord-023095-4dannjjm 883 5 , , , cord-023095-4dannjjm 883 6 New New NNP cord-023095-4dannjjm 883 7 Bolton Bolton NNP cord-023095-4dannjjm 883 8 Center Center NNP cord-023095-4dannjjm 883 9 , , , cord-023095-4dannjjm 883 10 Kennett Kennett NNP cord-023095-4dannjjm 883 11 Square Square NNP cord-023095-4dannjjm 883 12 , , , cord-023095-4dannjjm 883 13 PA PA NNP cord-023095-4dannjjm 883 14 . . . cord-023095-4dannjjm 884 1 2 2 CD cord-023095-4dannjjm 884 2 University University NNP cord-023095-4dannjjm 884 3 of of IN cord-023095-4dannjjm 884 4 Illinois Illinois NNP cord-023095-4dannjjm 884 5 , , , cord-023095-4dannjjm 884 6 Champaign Champaign NNP cord-023095-4dannjjm 884 7 - - HYPH cord-023095-4dannjjm 884 8 Urbana Urbana NNP cord-023095-4dannjjm 884 9 , , , cord-023095-4dannjjm 884 10 IL IL NNP cord-023095-4dannjjm 884 11 . . . cord-023095-4dannjjm 885 1 Gentamicin Gentamicin NNP cord-023095-4dannjjm 885 2 is be VBZ cord-023095-4dannjjm 885 3 often often RB cord-023095-4dannjjm 885 4 used use VBN cord-023095-4dannjjm 885 5 to to TO cord-023095-4dannjjm 885 6 provide provide VB cord-023095-4dannjjm 885 7 gram gram NN cord-023095-4dannjjm 885 8 negative negative JJ cord-023095-4dannjjm 885 9 antimicrobial antimicrobial JJ cord-023095-4dannjjm 885 10 coverage coverage NN cord-023095-4dannjjm 885 11 in in IN cord-023095-4dannjjm 885 12 horses horse NNS cord-023095-4dannjjm 885 13 at at IN cord-023095-4dannjjm 885 14 6.6 6.6 CD cord-023095-4dannjjm 885 15 mg mg NNP cord-023095-4dannjjm 885 16 / / SYM cord-023095-4dannjjm 885 17 kg kg NNP cord-023095-4dannjjm 885 18 IV IV NNP cord-023095-4dannjjm 885 19 every every DT cord-023095-4dannjjm 885 20 24 24 CD cord-023095-4dannjjm 885 21 hours hour NNS cord-023095-4dannjjm 885 22 . . . cord-023095-4dannjjm 886 1 Therapeutic therapeutic JJ cord-023095-4dannjjm 886 2 drug drug NN cord-023095-4dannjjm 886 3 monitoring monitoring NN cord-023095-4dannjjm 886 4 in in IN cord-023095-4dannjjm 886 5 our -PRON- PRP$ cord-023095-4dannjjm 886 6 hospital hospital NN cord-023095-4dannjjm 886 7 suggests suggest VBZ cord-023095-4dannjjm 886 8 larger large JJR cord-023095-4dannjjm 886 9 doses dose NNS cord-023095-4dannjjm 886 10 are be VBP cord-023095-4dannjjm 886 11 required require VBN cord-023095-4dannjjm 886 12 in in IN cord-023095-4dannjjm 886 13 many many JJ cord-023095-4dannjjm 886 14 clinical clinical JJ cord-023095-4dannjjm 886 15 cases case NNS cord-023095-4dannjjm 886 16 to to TO cord-023095-4dannjjm 886 17 achieve achieve VB cord-023095-4dannjjm 886 18 the the DT cord-023095-4dannjjm 886 19 desired desire VBN cord-023095-4dannjjm 886 20 concentration concentration NN cord-023095-4dannjjm 886 21 ( ( -LRB- cord-023095-4dannjjm 886 22 8 8 CD cord-023095-4dannjjm 886 23 - - SYM cord-023095-4dannjjm 886 24 10Â 10â CD cord-023095-4dannjjm 886 25 minimum minimum JJ cord-023095-4dannjjm 886 26 inhibitory inhibitory JJ cord-023095-4dannjjm 886 27 concentration concentration NN cord-023095-4dannjjm 886 28 ) ) -RRB- cord-023095-4dannjjm 886 29 for for IN cord-023095-4dannjjm 886 30 common common JJ cord-023095-4dannjjm 886 31 bacterial bacterial JJ cord-023095-4dannjjm 886 32 isolates isolate NNS cord-023095-4dannjjm 886 33 ( ( -LRB- cord-023095-4dannjjm 886 34 peak peak NN cord-023095-4dannjjm 886 35 target target NN cord-023095-4dannjjm 886 36 range range NNP cord-023095-4dannjjm 886 37 32 32 CD cord-023095-4dannjjm 886 38 - - SYM cord-023095-4dannjjm 886 39 40 40 CD cord-023095-4dannjjm 886 40 mg mg NNP cord-023095-4dannjjm 886 41 / / SYM cord-023095-4dannjjm 886 42 ml ml NNP cord-023095-4dannjjm 886 43 ) ) -RRB- cord-023095-4dannjjm 886 44 . . . cord-023095-4dannjjm 887 1 The the DT cord-023095-4dannjjm 887 2 aim aim NN cord-023095-4dannjjm 887 3 of of IN cord-023095-4dannjjm 887 4 this this DT cord-023095-4dannjjm 887 5 study study NN cord-023095-4dannjjm 887 6 was be VBD cord-023095-4dannjjm 887 7 to to TO cord-023095-4dannjjm 887 8 determine determine VB cord-023095-4dannjjm 887 9 the the DT cord-023095-4dannjjm 887 10 correlation correlation NN cord-023095-4dannjjm 887 11 between between IN cord-023095-4dannjjm 887 12 gentamicin gentamicin NN cord-023095-4dannjjm 887 13 dose dose NN cord-023095-4dannjjm 887 14 and and CC cord-023095-4dannjjm 887 15 plasma plasma NN cord-023095-4dannjjm 887 16 concentration concentration NN cord-023095-4dannjjm 887 17 in in IN cord-023095-4dannjjm 887 18 hospitalized hospitalize VBN cord-023095-4dannjjm 887 19 horses horse NNS cord-023095-4dannjjm 887 20 receiving receive VBG cord-023095-4dannjjm 887 21 gentamicin gentamicin NN cord-023095-4dannjjm 887 22 treatment treatment NN cord-023095-4dannjjm 887 23 in in IN cord-023095-4dannjjm 887 24 order order NN cord-023095-4dannjjm 887 25 to to TO cord-023095-4dannjjm 887 26 identify identify VB cord-023095-4dannjjm 887 27 an an DT cord-023095-4dannjjm 887 28 optimum optimum JJ cord-023095-4dannjjm 887 29 dose dose NN cord-023095-4dannjjm 887 30 range range NN cord-023095-4dannjjm 887 31 for for IN cord-023095-4dannjjm 887 32 this this DT cord-023095-4dannjjm 887 33 population population NN cord-023095-4dannjjm 887 34 . . . cord-023095-4dannjjm 888 1 Review Review NNP cord-023095-4dannjjm 888 2 of of IN cord-023095-4dannjjm 888 3 records record NNS cord-023095-4dannjjm 888 4 ( ( -LRB- cord-023095-4dannjjm 888 5 2002 2002 CD cord-023095-4dannjjm 888 6 ) ) -RRB- cord-023095-4dannjjm 888 7 ( ( -LRB- cord-023095-4dannjjm 888 8 2003 2003 CD cord-023095-4dannjjm 888 9 ) ) -RRB- cord-023095-4dannjjm 888 10 ( ( -LRB- cord-023095-4dannjjm 888 11 2004 2004 CD cord-023095-4dannjjm 888 12 ) ) -RRB- cord-023095-4dannjjm 888 13 ( ( -LRB- cord-023095-4dannjjm 888 14 2005 2005 CD cord-023095-4dannjjm 888 15 ) ) -RRB- cord-023095-4dannjjm 888 16 ( ( -LRB- cord-023095-4dannjjm 888 17 2006 2006 CD cord-023095-4dannjjm 888 18 ) ) -RRB- cord-023095-4dannjjm 888 19 ( ( -LRB- cord-023095-4dannjjm 888 20 2007 2007 CD cord-023095-4dannjjm 888 21 ) ) -RRB- cord-023095-4dannjjm 889 1 ( ( -LRB- cord-023095-4dannjjm 889 2 2008 2008 CD cord-023095-4dannjjm 889 3 ) ) -RRB- cord-023095-4dannjjm 890 1 ( ( -LRB- cord-023095-4dannjjm 890 2 2009 2009 CD cord-023095-4dannjjm 890 3 ) ) -RRB- cord-023095-4dannjjm 891 1 ( ( -LRB- cord-023095-4dannjjm 891 2 2010 2010 CD cord-023095-4dannjjm 891 3 ) ) -RRB- cord-023095-4dannjjm 891 4 identified identify VBD cord-023095-4dannjjm 891 5 71 71 CD cord-023095-4dannjjm 891 6 horses horse NNS cord-023095-4dannjjm 891 7 ! ! . cord-023095-4dannjjm 892 1 3 3 CD cord-023095-4dannjjm 892 2 months month NNS cord-023095-4dannjjm 892 3 old old JJ cord-023095-4dannjjm 892 4 receiving receive VBG cord-023095-4dannjjm 892 5 once once RB cord-023095-4dannjjm 892 6 - - HYPH cord-023095-4dannjjm 892 7 daily daily NN cord-023095-4dannjjm 892 8 gentamicin gentamicin NN cord-023095-4dannjjm 892 9 with with IN cord-023095-4dannjjm 893 1 peak peak NNP cord-023095-4dannjjm 893 2 and and CC cord-023095-4dannjjm 893 3 trough trough NN cord-023095-4dannjjm 893 4 assays assay NNS cord-023095-4dannjjm 893 5 performed perform VBD cord-023095-4dannjjm 893 6 ( ( -LRB- cord-023095-4dannjjm 893 7 N n CD cord-023095-4dannjjm 893 8 5 5 CD cord-023095-4dannjjm 893 9 107 107 CD cord-023095-4dannjjm 893 10 sets set NNS cord-023095-4dannjjm 893 11 ) ) -RRB- cord-023095-4dannjjm 893 12 . . . cord-023095-4dannjjm 894 1 Spearman Spearman NNP cord-023095-4dannjjm 894 2 Rank Rank NNP cord-023095-4dannjjm 894 3 Correlation Correlation NNP cord-023095-4dannjjm 894 4 coefficient coefficient NN cord-023095-4dannjjm 894 5 analysis analysis NN cord-023095-4dannjjm 894 6 revealed reveal VBD cord-023095-4dannjjm 894 7 a a DT cord-023095-4dannjjm 894 8 weak weak JJ cord-023095-4dannjjm 894 9 ( ( -LRB- cord-023095-4dannjjm 894 10 R r NN cord-023095-4dannjjm 894 11 5 5 CD cord-023095-4dannjjm 894 12 0.289 0.289 CD cord-023095-4dannjjm 894 13 ) ) -RRB- cord-023095-4dannjjm 894 14 but but CC cord-023095-4dannjjm 894 15 statistically statistically RB cord-023095-4dannjjm 894 16 significant significant JJ cord-023095-4dannjjm 894 17 correlation correlation NN cord-023095-4dannjjm 894 18 ( ( -LRB- cord-023095-4dannjjm 894 19 P p NN cord-023095-4dannjjm 894 20 5 5 CD cord-023095-4dannjjm 894 21 0.003 0.003 CD cord-023095-4dannjjm 894 22 ) ) -RRB- cord-023095-4dannjjm 894 23 between between IN cord-023095-4dannjjm 894 24 gentamicin gentamicin NNS cord-023095-4dannjjm 894 25 dose dose NN cord-023095-4dannjjm 894 26 and and CC cord-023095-4dannjjm 894 27 peak peak NN cord-023095-4dannjjm 894 28 plasma plasma NN cord-023095-4dannjjm 894 29 concentration concentration NN cord-023095-4dannjjm 894 30 . . . cord-023095-4dannjjm 895 1 Horses horse NNS cord-023095-4dannjjm 895 2 receiving receive VBG cord-023095-4dannjjm 895 3 7.7 7.7 CD cord-023095-4dannjjm 895 4 - - SYM cord-023095-4dannjjm 895 5 9.7 9.7 CD cord-023095-4dannjjm 895 6 and and CC cord-023095-4dannjjm 895 7 4 4 CD cord-023095-4dannjjm 895 8 9.7 9.7 CD cord-023095-4dannjjm 895 9 mg mg NN cord-023095-4dannjjm 895 10 / / SYM cord-023095-4dannjjm 895 11 kg kg NN cord-023095-4dannjjm 895 12 gentamicin gentamicin NNP cord-023095-4dannjjm 895 13 ( ( -LRB- cord-023095-4dannjjm 895 14 Groups group NNS cord-023095-4dannjjm 895 15 2 2 CD cord-023095-4dannjjm 895 16 and and CC cord-023095-4dannjjm 895 17 3 3 LS cord-023095-4dannjjm 895 18 ) ) -RRB- cord-023095-4dannjjm 895 19 had have VBD cord-023095-4dannjjm 895 20 higher high JJR cord-023095-4dannjjm 895 21 median median JJ cord-023095-4dannjjm 895 22 peaks peak NNS cord-023095-4dannjjm 895 23 ( ( -LRB- cord-023095-4dannjjm 895 24 31 31 CD cord-023095-4dannjjm 895 25 mg mg NNP cord-023095-4dannjjm 895 26 / / SYM cord-023095-4dannjjm 895 27 ml ml NNP cord-023095-4dannjjm 895 28 ) ) -RRB- cord-023095-4dannjjm 895 29 than than IN cord-023095-4dannjjm 895 30 horses horse NNS cord-023095-4dannjjm 895 31 receiving receive VBG cord-023095-4dannjjm 895 32 5.6 5.6 CD cord-023095-4dannjjm 895 33 - - SYM cord-023095-4dannjjm 895 34 7.6 7.6 CD cord-023095-4dannjjm 895 35 mg mg NNP cord-023095-4dannjjm 895 36 / / SYM cord-023095-4dannjjm 895 37 kg kg NNP cord-023095-4dannjjm 895 38 ( ( -LRB- cord-023095-4dannjjm 895 39 Group Group NNP cord-023095-4dannjjm 895 40 1 1 CD cord-023095-4dannjjm 895 41 ; ; : cord-023095-4dannjjm 895 42 25.7 25.7 CD cord-023095-4dannjjm 895 43 mg mg NNP cord-023095-4dannjjm 895 44 / / SYM cord-023095-4dannjjm 895 45 ml ml NNP cord-023095-4dannjjm 895 46 ) ) -RRB- cord-023095-4dannjjm 895 47 . . . cord-023095-4dannjjm 896 1 Higher high JJR cord-023095-4dannjjm 896 2 doses dose NNS cord-023095-4dannjjm 896 3 were be VBD cord-023095-4dannjjm 896 4 more more RBR cord-023095-4dannjjm 896 5 likely likely JJ cord-023095-4dannjjm 896 6 to to TO cord-023095-4dannjjm 896 7 result result VB cord-023095-4dannjjm 896 8 in in IN cord-023095-4dannjjm 896 9 peaks peak NNS cord-023095-4dannjjm 896 10 4 4 CD cord-023095-4dannjjm 896 11 32 32 CD cord-023095-4dannjjm 896 12 mg mg NNP cord-023095-4dannjjm 896 13 / / SYM cord-023095-4dannjjm 896 14 ml ml NN cord-023095-4dannjjm 896 15 ( ( -LRB- cord-023095-4dannjjm 896 16 42 42 CD cord-023095-4dannjjm 896 17 and and CC cord-023095-4dannjjm 896 18 41 41 CD cord-023095-4dannjjm 896 19 % % NN cord-023095-4dannjjm 896 20 , , , cord-023095-4dannjjm 896 21 Groups Groups NNPS cord-023095-4dannjjm 896 22 2 2 CD cord-023095-4dannjjm 896 23 and and CC cord-023095-4dannjjm 896 24 3 3 CD cord-023095-4dannjjm 896 25 respectively respectively RB cord-023095-4dannjjm 896 26 ) ) -RRB- cord-023095-4dannjjm 896 27 than than IN cord-023095-4dannjjm 896 28 horses horse NNS cord-023095-4dannjjm 896 29 receiving receive VBG cord-023095-4dannjjm 896 30 5.6 5.6 CD cord-023095-4dannjjm 896 31 - - SYM cord-023095-4dannjjm 896 32 7.6 7.6 CD cord-023095-4dannjjm 896 33 mg mg NNP cord-023095-4dannjjm 896 34 / / SYM cord-023095-4dannjjm 896 35 kg kg NNP cord-023095-4dannjjm 896 36 ( ( -LRB- cord-023095-4dannjjm 896 37 Group Group NNP cord-023095-4dannjjm 896 38 1 1 CD cord-023095-4dannjjm 896 39 ; ; : cord-023095-4dannjjm 896 40 16 16 CD cord-023095-4dannjjm 896 41 % % NN cord-023095-4dannjjm 896 42 ) ) -RRB- cord-023095-4dannjjm 896 43 . . . cord-023095-4dannjjm 897 1 All all DT cord-023095-4dannjjm 897 2 22 22 CD cord-023095-4dannjjm 897 3 hour hour NN cord-023095-4dannjjm 897 4 post post NN cord-023095-4dannjjm 897 5 - - JJ cord-023095-4dannjjm 897 6 gentamicin gentamicin JJ cord-023095-4dannjjm 897 7 administration administration NN cord-023095-4dannjjm 897 8 trough trough NN cord-023095-4dannjjm 897 9 values value NNS cord-023095-4dannjjm 897 10 were be VBD cord-023095-4dannjjm 897 11 o o XX cord-023095-4dannjjm 898 1 2 2 CD cord-023095-4dannjjm 898 2 mg mg NNP cord-023095-4dannjjm 898 3 / / SYM cord-023095-4dannjjm 898 4 ml ml NN cord-023095-4dannjjm 898 5 . . . cord-023095-4dannjjm 899 1 No no DT cord-023095-4dannjjm 899 2 correlation correlation NN cord-023095-4dannjjm 899 3 was be VBD cord-023095-4dannjjm 899 4 found find VBN cord-023095-4dannjjm 899 5 between between IN cord-023095-4dannjjm 899 6 dose dose NN cord-023095-4dannjjm 899 7 and and CC cord-023095-4dannjjm 899 8 change change NN cord-023095-4dannjjm 899 9 in in IN cord-023095-4dannjjm 899 10 plasma plasma NN cord-023095-4dannjjm 899 11 creatinine creatinine NN cord-023095-4dannjjm 899 12 during during IN cord-023095-4dannjjm 899 13 treatment treatment NN cord-023095-4dannjjm 899 14 , , , cord-023095-4dannjjm 899 15 nor nor CC cord-023095-4dannjjm 899 16 dose dose NN cord-023095-4dannjjm 899 17 and and CC cord-023095-4dannjjm 899 18 trough trough NN cord-023095-4dannjjm 899 19 level level NN cord-023095-4dannjjm 899 20 . . . cord-023095-4dannjjm 900 1 These these DT cord-023095-4dannjjm 900 2 data datum NNS cord-023095-4dannjjm 900 3 suggest suggest VBP cord-023095-4dannjjm 900 4 that that IN cord-023095-4dannjjm 900 5 gentamicin gentamicin NN cord-023095-4dannjjm 900 6 dosage dosage NN cord-023095-4dannjjm 900 7 in in IN cord-023095-4dannjjm 900 8 horses horse NNS cord-023095-4dannjjm 900 9 should should MD cord-023095-4dannjjm 900 10 be be VB cord-023095-4dannjjm 900 11 individually individually RB cord-023095-4dannjjm 900 12 determined determine VBN cord-023095-4dannjjm 900 13 by by IN cord-023095-4dannjjm 900 14 therapeutic therapeutic JJ cord-023095-4dannjjm 900 15 monitoring monitoring NN cord-023095-4dannjjm 900 16 . . . cord-023095-4dannjjm 901 1 Additionally additionally RB cord-023095-4dannjjm 901 2 , , , cord-023095-4dannjjm 901 3 these these DT cord-023095-4dannjjm 901 4 data datum NNS cord-023095-4dannjjm 901 5 support support VBP cord-023095-4dannjjm 901 6 an an DT cord-023095-4dannjjm 901 7 initial initial JJ cord-023095-4dannjjm 901 8 dose dose NN cord-023095-4dannjjm 901 9 of of IN cord-023095-4dannjjm 901 10 7.7 7.7 CD cord-023095-4dannjjm 901 11 - - SYM cord-023095-4dannjjm 901 12 9.7 9.7 CD cord-023095-4dannjjm 901 13 mg mg NNP cord-023095-4dannjjm 901 14 / / SYM cord-023095-4dannjjm 901 15 kg kg NNP cord-023095-4dannjjm 901 16 IV IV NNP cord-023095-4dannjjm 901 17 every every DT cord-023095-4dannjjm 901 18 24 24 CD cord-023095-4dannjjm 901 19 hours hour NNS cord-023095-4dannjjm 901 20 in in IN cord-023095-4dannjjm 901 21 order order NN cord-023095-4dannjjm 901 22 to to TO cord-023095-4dannjjm 901 23 achieve achieve VB cord-023095-4dannjjm 901 24 desired desire VBN cord-023095-4dannjjm 901 25 peak peak NN cord-023095-4dannjjm 901 26 concentration concentration NN cord-023095-4dannjjm 901 27 and and CC cord-023095-4dannjjm 901 28 an an DT cord-023095-4dannjjm 901 29 appropriately appropriately RB cord-023095-4dannjjm 901 30 low low JJ cord-023095-4dannjjm 901 31 trough trough NN cord-023095-4dannjjm 901 32 concentration concentration NN cord-023095-4dannjjm 901 33 . . . cord-023095-4dannjjm 902 1 Heaves Heaves NNP cord-023095-4dannjjm 902 2 is be VBZ cord-023095-4dannjjm 902 3 a a DT cord-023095-4dannjjm 902 4 common common JJ cord-023095-4dannjjm 902 5 respiratory respiratory JJ cord-023095-4dannjjm 902 6 inflammatory inflammatory JJ cord-023095-4dannjjm 902 7 disease disease NN cord-023095-4dannjjm 902 8 , , , cord-023095-4dannjjm 902 9 characterized characterize VBN cord-023095-4dannjjm 902 10 by by IN cord-023095-4dannjjm 902 11 a a DT cord-023095-4dannjjm 902 12 pulmonary pulmonary JJ cord-023095-4dannjjm 902 13 neutrophilia neutrophilia NN cord-023095-4dannjjm 902 14 . . . cord-023095-4dannjjm 903 1 This this DT cord-023095-4dannjjm 903 2 disease disease NN cord-023095-4dannjjm 903 3 is be VBZ cord-023095-4dannjjm 903 4 also also RB cord-023095-4dannjjm 903 5 characterized characterize VBN cord-023095-4dannjjm 903 6 by by IN cord-023095-4dannjjm 903 7 an an DT cord-023095-4dannjjm 903 8 activation activation NN cord-023095-4dannjjm 903 9 of of IN cord-023095-4dannjjm 903 10 circulating circulate VBG cord-023095-4dannjjm 903 11 neutrophils neutrophil NNS cord-023095-4dannjjm 903 12 after after IN cord-023095-4dannjjm 903 13 antigen antigen NN cord-023095-4dannjjm 903 14 challenge challenge NN cord-023095-4dannjjm 903 15 but but CC cord-023095-4dannjjm 903 16 their -PRON- PRP$ cord-023095-4dannjjm 903 17 specific specific JJ cord-023095-4dannjjm 903 18 role role NN cord-023095-4dannjjm 903 19 in in IN cord-023095-4dannjjm 903 20 heaves heaves NN cord-023095-4dannjjm 903 21 is be VBZ cord-023095-4dannjjm 903 22 not not RB cord-023095-4dannjjm 903 23 well well RB cord-023095-4dannjjm 903 24 understood understand VBN cord-023095-4dannjjm 903 25 . . . cord-023095-4dannjjm 904 1 Also also RB cord-023095-4dannjjm 904 2 , , , cord-023095-4dannjjm 904 3 there there EX cord-023095-4dannjjm 904 4 are be VBP cord-023095-4dannjjm 904 5 anecdotal anecdotal JJ cord-023095-4dannjjm 904 6 studies study NNS cord-023095-4dannjjm 904 7 concerning concern VBG cord-023095-4dannjjm 904 8 heaves heave NNS cord-023095-4dannjjm 904 9 - - HYPH cord-023095-4dannjjm 904 10 affected affect VBN cord-023095-4dannjjm 904 11 horse horse NN cord-023095-4dannjjm 904 12 to to TO cord-023095-4dannjjm 904 13 be be VB cord-023095-4dannjjm 904 14 more more RBR cord-023095-4dannjjm 904 15 susceptible susceptible JJ cord-023095-4dannjjm 904 16 to to IN cord-023095-4dannjjm 904 17 infection infection NN cord-023095-4dannjjm 904 18 . . . cord-023095-4dannjjm 905 1 However however RB cord-023095-4dannjjm 905 2 , , , cord-023095-4dannjjm 905 3 to to IN cord-023095-4dannjjm 905 4 our -PRON- PRP$ cord-023095-4dannjjm 905 5 knowledge knowledge NN cord-023095-4dannjjm 905 6 , , , cord-023095-4dannjjm 905 7 the the DT cord-023095-4dannjjm 905 8 antibacterial antibacterial JJ cord-023095-4dannjjm 905 9 host host NN cord-023095-4dannjjm 905 10 defense defense NN cord-023095-4dannjjm 905 11 role role NN cord-023095-4dannjjm 905 12 mediated mediate VBN cord-023095-4dannjjm 905 13 by by IN cord-023095-4dannjjm 905 14 circulating circulate VBG cord-023095-4dannjjm 905 15 neutrophils neutrophil NNS cord-023095-4dannjjm 905 16 was be VBD cord-023095-4dannjjm 905 17 not not RB cord-023095-4dannjjm 905 18 investigated investigate VBN cord-023095-4dannjjm 905 19 in in IN cord-023095-4dannjjm 905 20 heaves heaves NN cord-023095-4dannjjm 905 21 - - HYPH cord-023095-4dannjjm 905 22 affected affect VBN cord-023095-4dannjjm 905 23 horses horse NNS cord-023095-4dannjjm 905 24 . . . cord-023095-4dannjjm 906 1 The the DT cord-023095-4dannjjm 906 2 objective objective NN cord-023095-4dannjjm 906 3 of of IN cord-023095-4dannjjm 906 4 this this DT cord-023095-4dannjjm 906 5 study study NN cord-023095-4dannjjm 906 6 was be VBD cord-023095-4dannjjm 906 7 to to TO cord-023095-4dannjjm 906 8 compare compare VB cord-023095-4dannjjm 906 9 phagocytosis phagocytosis NN cord-023095-4dannjjm 906 10 activity activity NN cord-023095-4dannjjm 906 11 and and CC cord-023095-4dannjjm 906 12 bacterial bacterial JJ cord-023095-4dannjjm 906 13 killing killing NN cord-023095-4dannjjm 906 14 by by IN cord-023095-4dannjjm 906 15 circulating circulate VBG cord-023095-4dannjjm 906 16 blood blood NN cord-023095-4dannjjm 906 17 neutrophils neutrophil NNS cord-023095-4dannjjm 906 18 of of IN cord-023095-4dannjjm 906 19 heaves heave NNS cord-023095-4dannjjm 906 20 - - HYPH cord-023095-4dannjjm 906 21 affected affect VBN cord-023095-4dannjjm 906 22 and and CC cord-023095-4dannjjm 906 23 control control NN cord-023095-4dannjjm 906 24 horses horse NNS cord-023095-4dannjjm 906 25 . . . cord-023095-4dannjjm 907 1 Peripheral peripheral JJ cord-023095-4dannjjm 907 2 neutrophils neutrophil NNS cord-023095-4dannjjm 907 3 were be VBD cord-023095-4dannjjm 907 4 isolated isolate VBN cord-023095-4dannjjm 907 5 from from IN cord-023095-4dannjjm 907 6 heaves heave NNS cord-023095-4dannjjm 907 7 - - HYPH cord-023095-4dannjjm 907 8 affected affect VBN cord-023095-4dannjjm 907 9 ( ( -LRB- cord-023095-4dannjjm 907 10 n n NN cord-023095-4dannjjm 907 11 5 5 CD cord-023095-4dannjjm 907 12 6 6 CD cord-023095-4dannjjm 907 13 ) ) -RRB- cord-023095-4dannjjm 907 14 and and CC cord-023095-4dannjjm 907 15 control control NN cord-023095-4dannjjm 907 16 ( ( -LRB- cord-023095-4dannjjm 907 17 n n NN cord-023095-4dannjjm 907 18 5 5 CD cord-023095-4dannjjm 907 19 6 6 CD cord-023095-4dannjjm 907 20 ) ) -RRB- cord-023095-4dannjjm 907 21 horses horse NNS cord-023095-4dannjjm 907 22 using use VBG cord-023095-4dannjjm 907 23 a a DT cord-023095-4dannjjm 907 24 density density NN cord-023095-4dannjjm 907 25 gradient gradient NN cord-023095-4dannjjm 907 26 technique technique NN cord-023095-4dannjjm 907 27 . . . cord-023095-4dannjjm 908 1 The the DT cord-023095-4dannjjm 908 2 killing killing NN cord-023095-4dannjjm 908 3 capacity capacity NN cord-023095-4dannjjm 908 4 was be VBD cord-023095-4dannjjm 908 5 assessed assess VBN cord-023095-4dannjjm 908 6 by by IN cord-023095-4dannjjm 908 7 incubating incubate VBG cord-023095-4dannjjm 908 8 neutrophils neutrophil NNS cord-023095-4dannjjm 908 9 with with IN cord-023095-4dannjjm 908 10 Streptococcus streptococcus NN cord-023095-4dannjjm 908 11 equi equi NN cord-023095-4dannjjm 908 12 spp spp NN cord-023095-4dannjjm 908 13 equi equi NN cord-023095-4dannjjm 908 14 and and CC cord-023095-4dannjjm 908 15 spp spp NNP cord-023095-4dannjjm 908 16 zooepidemicus zooepidemicus NNP cord-023095-4dannjjm 908 17 . . . cord-023095-4dannjjm 909 1 After after IN cord-023095-4dannjjm 909 2 1 1 CD cord-023095-4dannjjm 909 3 h h NN cord-023095-4dannjjm 909 4 of of IN cord-023095-4dannjjm 909 5 bacterianeutrophil bacterianeutrophil NNP cord-023095-4dannjjm 909 6 coculture coculture NNP cord-023095-4dannjjm 909 7 , , , cord-023095-4dannjjm 909 8 total total JJ cord-023095-4dannjjm 909 9 viable viable JJ cord-023095-4dannjjm 909 10 bacterial bacterial JJ cord-023095-4dannjjm 909 11 cells cell NNS cord-023095-4dannjjm 909 12 were be VBD cord-023095-4dannjjm 909 13 measured measure VBN cord-023095-4dannjjm 909 14 by by IN cord-023095-4dannjjm 909 15 quantitative quantitative JJ cord-023095-4dannjjm 909 16 plating plating NN cord-023095-4dannjjm 909 17 . . . cord-023095-4dannjjm 910 1 The the DT cord-023095-4dannjjm 910 2 phagocytosis phagocytosis NN cord-023095-4dannjjm 910 3 was be VBD cord-023095-4dannjjm 910 4 evaluated evaluate VBN cord-023095-4dannjjm 910 5 by by IN cord-023095-4dannjjm 910 6 flow flow NN cord-023095-4dannjjm 910 7 cytometry cytometry NN cord-023095-4dannjjm 910 8 using use VBG cord-023095-4dannjjm 910 9 fluorescent fluorescent JJ cord-023095-4dannjjm 910 10 beads bead NNS cord-023095-4dannjjm 910 11 and and CC cord-023095-4dannjjm 910 12 GFP GFP NNP cord-023095-4dannjjm 910 13 - - HYPH cord-023095-4dannjjm 910 14 transformed transform VBN cord-023095-4dannjjm 910 15 Streptococcus Streptococcus NNP cord-023095-4dannjjm 910 16 suis suis FW cord-023095-4dannjjm 910 17 suilysin suilysin JJ cord-023095-4dannjjm 910 18 - - HYPH cord-023095-4dannjjm 910 19 negative negative JJ cord-023095-4dannjjm 910 20 mutant mutant JJ cord-023095-4dannjjm 910 21 strain strain NN cord-023095-4dannjjm 910 22 . . . cord-023095-4dannjjm 911 1 Circulating circulate VBG cord-023095-4dannjjm 911 2 neutrophils neutrophil NNS cord-023095-4dannjjm 911 3 from from IN cord-023095-4dannjjm 911 4 heaves heave NNS cord-023095-4dannjjm 911 5 - - HYPH cord-023095-4dannjjm 911 6 affected affect VBN cord-023095-4dannjjm 911 7 horses horse NNS cord-023095-4dannjjm 911 8 showed show VBD cord-023095-4dannjjm 911 9 a a DT cord-023095-4dannjjm 911 10 significant significant JJ cord-023095-4dannjjm 911 11 decrease decrease NN cord-023095-4dannjjm 911 12 in in IN cord-023095-4dannjjm 911 13 their -PRON- PRP$ cord-023095-4dannjjm 911 14 killing killing NN cord-023095-4dannjjm 911 15 capacity capacity NN cord-023095-4dannjjm 911 16 toward toward IN cord-023095-4dannjjm 911 17 S. S. NNP cord-023095-4dannjjm 911 18 zooepidemicus zooepidemicus NNP cord-023095-4dannjjm 911 19 ( ( -LRB- cord-023095-4dannjjm 911 20 p p NN cord-023095-4dannjjm 911 21 5 5 CD cord-023095-4dannjjm 911 22 0.046 0.046 CD cord-023095-4dannjjm 911 23 ) ) -RRB- cord-023095-4dannjjm 911 24 . . . cord-023095-4dannjjm 912 1 A a DT cord-023095-4dannjjm 912 2 reduced reduce VBN cord-023095-4dannjjm 912 3 , , , cord-023095-4dannjjm 912 4 although although IN cord-023095-4dannjjm 912 5 not not RB cord-023095-4dannjjm 912 6 significant significant JJ cord-023095-4dannjjm 912 7 ( ( -LRB- cord-023095-4dannjjm 912 8 p p NN cord-023095-4dannjjm 912 9 5 5 CD cord-023095-4dannjjm 912 10 0.1 0.1 CD cord-023095-4dannjjm 912 11 ) ) -RRB- cord-023095-4dannjjm 912 12 , , , cord-023095-4dannjjm 912 13 killing kill VBG cord-023095-4dannjjm 912 14 capacity capacity NN cord-023095-4dannjjm 912 15 of of IN cord-023095-4dannjjm 912 16 S. S. NNP cord-023095-4dannjjm 912 17 equi equi NN cord-023095-4dannjjm 912 18 by by IN cord-023095-4dannjjm 912 19 these these DT cord-023095-4dannjjm 912 20 neutrophils neutrophil NNS cord-023095-4dannjjm 912 21 was be VBD cord-023095-4dannjjm 912 22 also also RB cord-023095-4dannjjm 912 23 observed observe VBN cord-023095-4dannjjm 912 24 . . . cord-023095-4dannjjm 913 1 The the DT cord-023095-4dannjjm 913 2 phagocytosis phagocytosis NN cord-023095-4dannjjm 913 3 activity activity NN cord-023095-4dannjjm 913 4 was be VBD cord-023095-4dannjjm 913 5 not not RB cord-023095-4dannjjm 913 6 different different JJ cord-023095-4dannjjm 913 7 between between IN cord-023095-4dannjjm 913 8 groups group NNS cord-023095-4dannjjm 913 9 . . . cord-023095-4dannjjm 914 1 This this DT cord-023095-4dannjjm 914 2 impairment impairment NN cord-023095-4dannjjm 914 3 of of IN cord-023095-4dannjjm 914 4 blood blood NN cord-023095-4dannjjm 914 5 neutrophil neutrophil NN cord-023095-4dannjjm 914 6 bactericidal bactericidal JJ cord-023095-4dannjjm 914 7 activity activity NN cord-023095-4dannjjm 914 8 in in IN cord-023095-4dannjjm 914 9 heaves heaves NN cord-023095-4dannjjm 914 10 - - HYPH cord-023095-4dannjjm 914 11 affected affect VBN cord-023095-4dannjjm 914 12 horses horse NNS cord-023095-4dannjjm 914 13 could could MD cord-023095-4dannjjm 914 14 contribute contribute VB cord-023095-4dannjjm 914 15 to to IN cord-023095-4dannjjm 914 16 an an DT cord-023095-4dannjjm 914 17 increase increase NN cord-023095-4dannjjm 914 18 susceptibility susceptibility NN cord-023095-4dannjjm 914 19 to to IN cord-023095-4dannjjm 914 20 infection infection NN cord-023095-4dannjjm 914 21 . . . cord-023095-4dannjjm 915 1 Obesity obesity NN cord-023095-4dannjjm 915 2 is be VBZ cord-023095-4dannjjm 915 3 a a DT cord-023095-4dannjjm 915 4 common common JJ cord-023095-4dannjjm 915 5 disorder disorder NN cord-023095-4dannjjm 915 6 of of IN cord-023095-4dannjjm 915 7 the the DT cord-023095-4dannjjm 915 8 horse horse NN cord-023095-4dannjjm 915 9 , , , cord-023095-4dannjjm 915 10 with with IN cord-023095-4dannjjm 915 11 current current JJ cord-023095-4dannjjm 915 12 prevalence prevalence NN cord-023095-4dannjjm 915 13 estimated estimate VBN cord-023095-4dannjjm 915 14 at at IN cord-023095-4dannjjm 915 15 30 30 CD cord-023095-4dannjjm 915 16 % % NN cord-023095-4dannjjm 915 17 . . . cord-023095-4dannjjm 916 1 In in IN cord-023095-4dannjjm 916 2 people people NNS cord-023095-4dannjjm 916 3 , , , cord-023095-4dannjjm 916 4 obesity obesity NN cord-023095-4dannjjm 916 5 is be VBZ cord-023095-4dannjjm 916 6 associated associate VBN cord-023095-4dannjjm 916 7 with with IN cord-023095-4dannjjm 916 8 dyslipidemia dyslipidemia NN cord-023095-4dannjjm 916 9 , , , cord-023095-4dannjjm 916 10 insulin insulin NN cord-023095-4dannjjm 916 11 resistance resistance NN cord-023095-4dannjjm 916 12 , , , cord-023095-4dannjjm 916 13 mitochondrial mitochondrial JJ cord-023095-4dannjjm 916 14 dysfunction dysfunction NN cord-023095-4dannjjm 916 15 and and CC cord-023095-4dannjjm 916 16 downregulation downregulation NN cord-023095-4dannjjm 916 17 of of IN cord-023095-4dannjjm 916 18 lipid lipid NN cord-023095-4dannjjm 916 19 and and CC cord-023095-4dannjjm 916 20 glucose glucose NN cord-023095-4dannjjm 916 21 metabolic metabolic JJ cord-023095-4dannjjm 916 22 pathways pathway NNS cord-023095-4dannjjm 916 23 . . . cord-023095-4dannjjm 917 1 In in IN cord-023095-4dannjjm 917 2 the the DT cord-023095-4dannjjm 917 3 horse horse NN cord-023095-4dannjjm 917 4 , , , cord-023095-4dannjjm 917 5 obesity obesity NN cord-023095-4dannjjm 917 6 is be VBZ cord-023095-4dannjjm 917 7 similarly similarly RB cord-023095-4dannjjm 917 8 associated associate VBN cord-023095-4dannjjm 917 9 with with IN cord-023095-4dannjjm 917 10 insulin insulin NN cord-023095-4dannjjm 917 11 resistance resistance NN cord-023095-4dannjjm 917 12 and and CC cord-023095-4dannjjm 917 13 alterations alteration NNS cord-023095-4dannjjm 917 14 in in IN cord-023095-4dannjjm 917 15 lipid lipid NN cord-023095-4dannjjm 917 16 profiles profile NNS cord-023095-4dannjjm 917 17 ; ; : cord-023095-4dannjjm 917 18 however however RB cord-023095-4dannjjm 917 19 , , , cord-023095-4dannjjm 917 20 metabolic metabolic JJ cord-023095-4dannjjm 917 21 regulatory regulatory JJ cord-023095-4dannjjm 917 22 gene gene NN cord-023095-4dannjjm 917 23 expression expression NN cord-023095-4dannjjm 917 24 profiles profile NNS cord-023095-4dannjjm 917 25 have have VBP cord-023095-4dannjjm 917 26 not not RB cord-023095-4dannjjm 917 27 been be VBN cord-023095-4dannjjm 917 28 fully fully RB cord-023095-4dannjjm 917 29 characterized characterize VBN cord-023095-4dannjjm 917 30 . . . cord-023095-4dannjjm 918 1 We -PRON- PRP cord-023095-4dannjjm 918 2 hypothesized hypothesize VBD cord-023095-4dannjjm 918 3 that that IN cord-023095-4dannjjm 918 4 obese obese JJ cord-023095-4dannjjm 918 5 horses horse NNS cord-023095-4dannjjm 918 6 have have VBP cord-023095-4dannjjm 918 7 decreased decrease VBN cord-023095-4dannjjm 918 8 expression expression NN cord-023095-4dannjjm 918 9 of of IN cord-023095-4dannjjm 918 10 metabolic metabolic JJ cord-023095-4dannjjm 918 11 regulatory regulatory JJ cord-023095-4dannjjm 918 12 genes gene NNS cord-023095-4dannjjm 918 13 and and CC cord-023095-4dannjjm 918 14 decreased decrease VBD cord-023095-4dannjjm 918 15 mitochondrial mitochondrial JJ cord-023095-4dannjjm 918 16 content content NN cord-023095-4dannjjm 918 17 in in IN cord-023095-4dannjjm 918 18 skeletal skeletal JJ cord-023095-4dannjjm 918 19 muscle muscle NN cord-023095-4dannjjm 918 20 compared compare VBN cord-023095-4dannjjm 918 21 with with IN cord-023095-4dannjjm 918 22 non non JJ cord-023095-4dannjjm 918 23 - - JJ cord-023095-4dannjjm 918 24 obese obese JJ cord-023095-4dannjjm 918 25 horses horse NNS cord-023095-4dannjjm 918 26 . . . cord-023095-4dannjjm 919 1 Sixteen sixteen CD cord-023095-4dannjjm 919 2 light light JJ cord-023095-4dannjjm 919 3 breed breed NN cord-023095-4dannjjm 919 4 horses horse NNS cord-023095-4dannjjm 919 5 , , , cord-023095-4dannjjm 919 6 2 2 CD cord-023095-4dannjjm 919 7 - - SYM cord-023095-4dannjjm 919 8 27 27 CD cord-023095-4dannjjm 919 9 years year NNS cord-023095-4dannjjm 919 10 of of IN cord-023095-4dannjjm 919 11 age age NN cord-023095-4dannjjm 919 12 were be VBD cord-023095-4dannjjm 919 13 included include VBN cord-023095-4dannjjm 919 14 . . . cord-023095-4dannjjm 920 1 Body body NN cord-023095-4dannjjm 920 2 condition condition NN cord-023095-4dannjjm 920 3 score score NN cord-023095-4dannjjm 920 4 ( ( -LRB- cord-023095-4dannjjm 920 5 n n NN cord-023095-4dannjjm 920 6 5 5 CD cord-023095-4dannjjm 920 7 16 16 CD cord-023095-4dannjjm 920 8 ) ) -RRB- cord-023095-4dannjjm 920 9 and and CC cord-023095-4dannjjm 920 10 neck neck NN cord-023095-4dannjjm 920 11 circumference circumference NN cord-023095-4dannjjm 920 12 ( ( -LRB- cord-023095-4dannjjm 920 13 n n NN cord-023095-4dannjjm 920 14 5 5 CD cord-023095-4dannjjm 920 15 9 9 CD cord-023095-4dannjjm 920 16 ) ) -RRB- cord-023095-4dannjjm 920 17 were be VBD cord-023095-4dannjjm 920 18 recorded record VBN cord-023095-4dannjjm 920 19 . . . cord-023095-4dannjjm 921 1 Post post JJ cord-023095-4dannjjm 921 2 - - JJ cord-023095-4dannjjm 921 3 mortem mortem JJ cord-023095-4dannjjm 921 4 biopsy biopsy NN cord-023095-4dannjjm 921 5 samples sample NNS cord-023095-4dannjjm 921 6 of of IN cord-023095-4dannjjm 921 7 the the DT cord-023095-4dannjjm 921 8 semi semi JJ cord-023095-4dannjjm 921 9 - - JJ cord-023095-4dannjjm 921 10 membranosus membranosus JJ cord-023095-4dannjjm 921 11 muscle muscle NN cord-023095-4dannjjm 921 12 were be VBD cord-023095-4dannjjm 921 13 obtained obtain VBN cord-023095-4dannjjm 921 14 . . . cord-023095-4dannjjm 922 1 DNA DNA NNP cord-023095-4dannjjm 922 2 and and CC cord-023095-4dannjjm 922 3 RNA RNA NNP cord-023095-4dannjjm 922 4 were be VBD cord-023095-4dannjjm 922 5 isolated isolate VBN cord-023095-4dannjjm 922 6 . . . cord-023095-4dannjjm 923 1 Relative relative JJ cord-023095-4dannjjm 923 2 expression expression NN cord-023095-4dannjjm 923 3 of of IN cord-023095-4dannjjm 923 4 the the DT cord-023095-4dannjjm 923 5 metabolic metabolic JJ cord-023095-4dannjjm 923 6 genes gene NNS cord-023095-4dannjjm 923 7 , , , cord-023095-4dannjjm 923 8 peroxisome peroxisome NN cord-023095-4dannjjm 923 9 proliferator proliferator NN cord-023095-4dannjjm 923 10 activated activate VBD cord-023095-4dannjjm 923 11 receptor receptor NN cord-023095-4dannjjm 923 12 g g NN cord-023095-4dannjjm 923 13 ( ( -LRB- cord-023095-4dannjjm 923 14 PPARg PPARg NNP cord-023095-4dannjjm 923 15 ) ) -RRB- cord-023095-4dannjjm 923 16 , , , cord-023095-4dannjjm 923 17 PPARg PPARg NNS cord-023095-4dannjjm 923 18 coactivator-1a coactivator-1a NNP cord-023095-4dannjjm 923 19 ( ( -LRB- cord-023095-4dannjjm 923 20 PGC-1a PGC-1a NNP cord-023095-4dannjjm 923 21 ) ) -RRB- cord-023095-4dannjjm 923 22 , , , cord-023095-4dannjjm 923 23 fatty fatty JJ cord-023095-4dannjjm 923 24 acid acid NN cord-023095-4dannjjm 923 25 translocase translocase NN cord-023095-4dannjjm 923 26 ( ( -LRB- cord-023095-4dannjjm 923 27 FAT fat NN cord-023095-4dannjjm 923 28 ) ) -RRB- cord-023095-4dannjjm 923 29 and and CC cord-023095-4dannjjm 923 30 estrogen estrogen NN cord-023095-4dannjjm 923 31 related relate VBN cord-023095-4dannjjm 923 32 receptor receptor NN cord-023095-4dannjjm 923 33 a a NN cord-023095-4dannjjm 923 34 ( ( -LRB- cord-023095-4dannjjm 923 35 ERRa ERRa NNS cord-023095-4dannjjm 923 36 ) ) -RRB- cord-023095-4dannjjm 923 37 was be VBD cord-023095-4dannjjm 923 38 determined determine VBN cord-023095-4dannjjm 923 39 by by IN cord-023095-4dannjjm 923 40 quantitative quantitative JJ cord-023095-4dannjjm 923 41 polymerase polymerase NN cord-023095-4dannjjm 923 42 chain chain NN cord-023095-4dannjjm 923 43 reaction reaction NN cord-023095-4dannjjm 923 44 ( ( -LRB- cord-023095-4dannjjm 923 45 qPCR qPCR NNP cord-023095-4dannjjm 923 46 ) ) -RRB- cord-023095-4dannjjm 923 47 . . . cord-023095-4dannjjm 924 1 Mitochondrial mitochondrial JJ cord-023095-4dannjjm 924 2 content content NN cord-023095-4dannjjm 924 3 was be VBD cord-023095-4dannjjm 924 4 assessed assess VBN cord-023095-4dannjjm 924 5 by by IN cord-023095-4dannjjm 924 6 determining determine VBG cord-023095-4dannjjm 924 7 mitochondrial mitochondrial JJ cord-023095-4dannjjm 924 8 DNA dna NN cord-023095-4dannjjm 924 9 / / SYM cord-023095-4dannjjm 924 10 nuclear nuclear JJ cord-023095-4dannjjm 924 11 DNA dna NN cord-023095-4dannjjm 924 12 ratio ratio NN cord-023095-4dannjjm 924 13 by by IN cord-023095-4dannjjm 924 14 qPCR qPCR NNP cord-023095-4dannjjm 924 15 , , , cord-023095-4dannjjm 924 16 using use VBG cord-023095-4dannjjm 924 17 NADH NADH NNP cord-023095-4dannjjm 924 18 - - HYPH cord-023095-4dannjjm 924 19 dehydrogenase dehydrogenase NN cord-023095-4dannjjm 924 20 subunit subunit NN cord-023095-4dannjjm 924 21 2 2 CD cord-023095-4dannjjm 924 22 and and CC cord-023095-4dannjjm 924 23 cytochrome cytochrome NN cord-023095-4dannjjm 924 24 oxidase oxidase NN cord-023095-4dannjjm 924 25 subunit subunit NN cord-023095-4dannjjm 924 26 2 2 CD cord-023095-4dannjjm 924 27 as as IN cord-023095-4dannjjm 924 28 mitochondrial mitochondrial JJ cord-023095-4dannjjm 924 29 genes gene NNS cord-023095-4dannjjm 924 30 and and CC cord-023095-4dannjjm 924 31 beta beta NN cord-023095-4dannjjm 924 32 actin actin NN cord-023095-4dannjjm 924 33 as as IN cord-023095-4dannjjm 924 34 the the DT cord-023095-4dannjjm 924 35 nuclear nuclear JJ cord-023095-4dannjjm 924 36 reference reference NN cord-023095-4dannjjm 924 37 gene gene NN cord-023095-4dannjjm 924 38 . . . cord-023095-4dannjjm 925 1 Non non JJ cord-023095-4dannjjm 925 2 - - JJ cord-023095-4dannjjm 925 3 normal normal JJ cord-023095-4dannjjm 925 4 data datum NNS cord-023095-4dannjjm 925 5 was be VBD cord-023095-4dannjjm 925 6 log log NN cord-023095-4dannjjm 925 7 transformed transform VBN cord-023095-4dannjjm 925 8 for for IN cord-023095-4dannjjm 925 9 analysis analysis NN cord-023095-4dannjjm 925 10 and and CC cord-023095-4dannjjm 925 11 a a DT cord-023095-4dannjjm 925 12 Pearson Pearson NNP cord-023095-4dannjjm 925 13 coefficient coefficient NN cord-023095-4dannjjm 925 14 of of IN cord-023095-4dannjjm 925 15 correlation correlation NN cord-023095-4dannjjm 925 16 was be VBD cord-023095-4dannjjm 925 17 calculated calculate VBN cord-023095-4dannjjm 925 18 for for IN cord-023095-4dannjjm 925 19 relative relative JJ cord-023095-4dannjjm 925 20 gene gene NN cord-023095-4dannjjm 925 21 expression expression NN cord-023095-4dannjjm 925 22 , , , cord-023095-4dannjjm 925 23 body body NN cord-023095-4dannjjm 925 24 condition condition NN cord-023095-4dannjjm 925 25 score score NN cord-023095-4dannjjm 925 26 and and CC cord-023095-4dannjjm 925 27 neck neck NN cord-023095-4dannjjm 925 28 circumference circumference NN cord-023095-4dannjjm 925 29 . . . cord-023095-4dannjjm 926 1 A a DT cord-023095-4dannjjm 926 2 value value NN cord-023095-4dannjjm 926 3 of of IN cord-023095-4dannjjm 926 4 p p NN cord-023095-4dannjjm 926 5 o o NN cord-023095-4dannjjm 926 6 0.05 0.05 CD cord-023095-4dannjjm 926 7 was be VBD cord-023095-4dannjjm 926 8 considered consider VBN cord-023095-4dannjjm 926 9 significant significant JJ cord-023095-4dannjjm 926 10 . . . cord-023095-4dannjjm 927 1 Body body NN cord-023095-4dannjjm 927 2 condition condition NN cord-023095-4dannjjm 927 3 score score NN cord-023095-4dannjjm 927 4 was be VBD cord-023095-4dannjjm 927 5 strongly strongly RB cord-023095-4dannjjm 927 6 correlated correlate VBN cord-023095-4dannjjm 927 7 with with IN cord-023095-4dannjjm 927 8 neck neck NN cord-023095-4dannjjm 927 9 circumference circumference NN cord-023095-4dannjjm 928 1 ( ( -LRB- cord-023095-4dannjjm 928 2 n n NN cord-023095-4dannjjm 928 3 5 5 CD cord-023095-4dannjjm 928 4 9 9 CD cord-023095-4dannjjm 928 5 , , , cord-023095-4dannjjm 929 1 r r LS cord-023095-4dannjjm 929 2 5 5 CD cord-023095-4dannjjm 929 3 0.72 0.72 CD cord-023095-4dannjjm 929 4 , , , cord-023095-4dannjjm 929 5 p p NN cord-023095-4dannjjm 929 6 5 5 CD cord-023095-4dannjjm 929 7 0.03 0.03 CD cord-023095-4dannjjm 929 8 ) ) -RRB- cord-023095-4dannjjm 929 9 . . . cord-023095-4dannjjm 930 1 Relative relative JJ cord-023095-4dannjjm 930 2 expression expression NN cord-023095-4dannjjm 930 3 of of IN cord-023095-4dannjjm 930 4 ERRa ERRa NNS cord-023095-4dannjjm 930 5 and and CC cord-023095-4dannjjm 930 6 GLUT-4 GLUT-4 NNP cord-023095-4dannjjm 930 7 increased increase VBD cord-023095-4dannjjm 930 8 with with IN cord-023095-4dannjjm 930 9 body body NN cord-023095-4dannjjm 930 10 condition condition NN cord-023095-4dannjjm 930 11 score score NN cord-023095-4dannjjm 930 12 ( ( -LRB- cord-023095-4dannjjm 930 13 ERRa ERRa NNS cord-023095-4dannjjm 930 14 : : : cord-023095-4dannjjm 930 15 n n NN cord-023095-4dannjjm 930 16 5 5 CD cord-023095-4dannjjm 930 17 16 16 CD cord-023095-4dannjjm 930 18 , , , cord-023095-4dannjjm 930 19 r r NN cord-023095-4dannjjm 930 20 5 5 CD cord-023095-4dannjjm 930 21 0.66 0.66 CD cord-023095-4dannjjm 930 22 , , , cord-023095-4dannjjm 930 23 p p NN cord-023095-4dannjjm 930 24 5 5 CD cord-023095-4dannjjm 930 25 0.005 0.005 CD cord-023095-4dannjjm 930 26 ; ; : cord-023095-4dannjjm 931 1 GLUT-4 glut-4 NN cord-023095-4dannjjm 931 2 : : : cord-023095-4dannjjm 932 1 n n NN cord-023095-4dannjjm 932 2 5 5 CD cord-023095-4dannjjm 932 3 16 16 CD cord-023095-4dannjjm 932 4 , , , cord-023095-4dannjjm 932 5 r r NN cord-023095-4dannjjm 932 6 5 5 CD cord-023095-4dannjjm 932 7 0.50 0.50 CD cord-023095-4dannjjm 932 8 , , , cord-023095-4dannjjm 932 9 p p NN cord-023095-4dannjjm 932 10 5 5 CD cord-023095-4dannjjm 932 11 0.05 0.05 CD cord-023095-4dannjjm 932 12 ) ) -RRB- cord-023095-4dannjjm 932 13 . . . cord-023095-4dannjjm 933 1 Copy copy JJ cord-023095-4dannjjm 933 2 number number NN cord-023095-4dannjjm 933 3 of of IN cord-023095-4dannjjm 933 4 the the DT cord-023095-4dannjjm 933 5 mitochondrial mitochondrial JJ cord-023095-4dannjjm 933 6 genes gene NNS cord-023095-4dannjjm 933 7 ( ( -LRB- cord-023095-4dannjjm 933 8 NADH NADH NNP cord-023095-4dannjjm 933 9 - - HYPH cord-023095-4dannjjm 933 10 DH DH NNP cord-023095-4dannjjm 933 11 and and CC cord-023095-4dannjjm 933 12 COX-2 COX-2 NNP cord-023095-4dannjjm 933 13 ) ) -RRB- cord-023095-4dannjjm 933 14 was be VBD cord-023095-4dannjjm 933 15 not not RB cord-023095-4dannjjm 933 16 related relate VBN cord-023095-4dannjjm 933 17 to to IN cord-023095-4dannjjm 933 18 body body NN cord-023095-4dannjjm 933 19 condition condition NN cord-023095-4dannjjm 933 20 score score NN cord-023095-4dannjjm 933 21 or or CC cord-023095-4dannjjm 933 22 metabolic metabolic JJ cord-023095-4dannjjm 933 23 gene gene NN cord-023095-4dannjjm 933 24 expression expression NN cord-023095-4dannjjm 933 25 . . . cord-023095-4dannjjm 934 1 Expression expression NN cord-023095-4dannjjm 934 2 of of IN cord-023095-4dannjjm 934 3 GLUT-4 GLUT-4 NNP cord-023095-4dannjjm 934 4 , , , cord-023095-4dannjjm 934 5 ERRa ERRa NNS cord-023095-4dannjjm 934 6 , , , cord-023095-4dannjjm 934 7 PPARg PPARg NNS cord-023095-4dannjjm 934 8 , , , cord-023095-4dannjjm 934 9 and and CC cord-023095-4dannjjm 934 10 FAT fat NN cord-023095-4dannjjm 934 11 were be VBD cord-023095-4dannjjm 934 12 strongly strongly RB cord-023095-4dannjjm 934 13 correlated correlate VBN cord-023095-4dannjjm 934 14 to to IN cord-023095-4dannjjm 934 15 each each DT cord-023095-4dannjjm 934 16 other other JJ cord-023095-4dannjjm 934 17 , , , cord-023095-4dannjjm 934 18 but but CC cord-023095-4dannjjm 934 19 not not RB cord-023095-4dannjjm 934 20 PGC-1a PGC-1a NNP cord-023095-4dannjjm 934 21 . . . cord-023095-4dannjjm 935 1 There there EX cord-023095-4dannjjm 935 2 was be VBD cord-023095-4dannjjm 935 3 a a DT cord-023095-4dannjjm 935 4 strong strong JJ cord-023095-4dannjjm 935 5 trend trend NN cord-023095-4dannjjm 935 6 towards towards IN cord-023095-4dannjjm 935 7 correlation correlation NN cord-023095-4dannjjm 935 8 between between IN cord-023095-4dannjjm 935 9 PPARg PPARg NNS cord-023095-4dannjjm 935 10 and and CC cord-023095-4dannjjm 935 11 PGC-1a PGC-1a NNP cord-023095-4dannjjm 935 12 in in IN cord-023095-4dannjjm 935 13 horses horse NNS cord-023095-4dannjjm 935 14 with with IN cord-023095-4dannjjm 935 15 body body NN cord-023095-4dannjjm 935 16 condition condition NN cord-023095-4dannjjm 935 17 score score NN cord-023095-4dannjjm 935 18 4 4 CD cord-023095-4dannjjm 935 19 6 6 CD cord-023095-4dannjjm 935 20 ( ( -LRB- cord-023095-4dannjjm 935 21 n n NN cord-023095-4dannjjm 935 22 5 5 CD cord-023095-4dannjjm 935 23 6 6 CD cord-023095-4dannjjm 935 24 , , , cord-023095-4dannjjm 936 1 r r LS cord-023095-4dannjjm 936 2 5 5 CD cord-023095-4dannjjm 936 3 0.77 0.77 CD cord-023095-4dannjjm 936 4 , , , cord-023095-4dannjjm 936 5 p p NN cord-023095-4dannjjm 936 6 5 5 CD cord-023095-4dannjjm 936 7 0.07 0.07 CD cord-023095-4dannjjm 936 8 ) ) -RRB- cord-023095-4dannjjm 936 9 . . . cord-023095-4dannjjm 937 1 In in IN cord-023095-4dannjjm 937 2 this this DT cord-023095-4dannjjm 937 3 study study NN cord-023095-4dannjjm 937 4 , , , cord-023095-4dannjjm 937 5 there there EX cord-023095-4dannjjm 937 6 was be VBD cord-023095-4dannjjm 937 7 no no DT cord-023095-4dannjjm 937 8 change change NN cord-023095-4dannjjm 937 9 in in IN cord-023095-4dannjjm 937 10 mitochondrial mitochondrial JJ cord-023095-4dannjjm 937 11 content content NN cord-023095-4dannjjm 937 12 in in IN cord-023095-4dannjjm 937 13 obese obese JJ cord-023095-4dannjjm 937 14 horses horse NNS cord-023095-4dannjjm 937 15 . . . cord-023095-4dannjjm 938 1 Assessment assessment NN cord-023095-4dannjjm 938 2 of of IN cord-023095-4dannjjm 938 3 mitochondrial mitochondrial JJ cord-023095-4dannjjm 938 4 function function NN cord-023095-4dannjjm 938 5 in in IN cord-023095-4dannjjm 938 6 obese obese JJ cord-023095-4dannjjm 938 7 horses horse NNS cord-023095-4dannjjm 938 8 and and CC cord-023095-4dannjjm 938 9 horses horse NNS cord-023095-4dannjjm 938 10 with with IN cord-023095-4dannjjm 938 11 EMS EMS NNP cord-023095-4dannjjm 938 12 is be VBZ cord-023095-4dannjjm 938 13 under under IN cord-023095-4dannjjm 938 14 way way NN cord-023095-4dannjjm 938 15 . . . cord-023095-4dannjjm 939 1 The the DT cord-023095-4dannjjm 939 2 strong strong JJ cord-023095-4dannjjm 939 3 correlation correlation NN cord-023095-4dannjjm 939 4 between between IN cord-023095-4dannjjm 939 5 PPARg PPARg NNS cord-023095-4dannjjm 939 6 and and CC cord-023095-4dannjjm 939 7 PGC-1a PGC-1a NNP cord-023095-4dannjjm 939 8 observed observe VBD cord-023095-4dannjjm 939 9 only only RB cord-023095-4dannjjm 939 10 in in IN cord-023095-4dannjjm 939 11 horses horse NNS cord-023095-4dannjjm 939 12 with with IN cord-023095-4dannjjm 939 13 high high JJ cord-023095-4dannjjm 939 14 body body NN cord-023095-4dannjjm 939 15 condition condition NN cord-023095-4dannjjm 939 16 scores score NNS cord-023095-4dannjjm 940 1 suggests suggest VBZ cord-023095-4dannjjm 940 2 this this DT cord-023095-4dannjjm 940 3 pathway pathway NN cord-023095-4dannjjm 940 4 is be VBZ cord-023095-4dannjjm 940 5 activated activate VBN cord-023095-4dannjjm 940 6 with with IN cord-023095-4dannjjm 940 7 obesity obesity NN cord-023095-4dannjjm 940 8 . . . cord-023095-4dannjjm 941 1 The the DT cord-023095-4dannjjm 941 2 role role NN cord-023095-4dannjjm 941 3 of of IN cord-023095-4dannjjm 941 4 PPARg PPARg NNS cord-023095-4dannjjm 941 5 and and CC cord-023095-4dannjjm 941 6 PGC-1a PGC-1a NNP cord-023095-4dannjjm 941 7 in in IN cord-023095-4dannjjm 941 8 equine equine JJ cord-023095-4dannjjm 941 9 obesity obesity NN cord-023095-4dannjjm 941 10 should should MD cord-023095-4dannjjm 941 11 be be VB cord-023095-4dannjjm 941 12 further further RB cord-023095-4dannjjm 941 13 investigated investigate VBN cord-023095-4dannjjm 941 14 to to TO cord-023095-4dannjjm 941 15 determine determine VB cord-023095-4dannjjm 941 16 their -PRON- PRP$ cord-023095-4dannjjm 941 17 potential potential NN cord-023095-4dannjjm 941 18 as as IN cord-023095-4dannjjm 941 19 therapeutic therapeutic JJ cord-023095-4dannjjm 941 20 targets target NNS cord-023095-4dannjjm 941 21 . . . cord-023095-4dannjjm 942 1 Upregulation Upregulation NNP cord-023095-4dannjjm 942 2 of of IN cord-023095-4dannjjm 942 3 ERRa ERRa NNS cord-023095-4dannjjm 942 4 and and CC cord-023095-4dannjjm 942 5 GLUT-4 glut-4 NN cord-023095-4dannjjm 942 6 in in IN cord-023095-4dannjjm 942 7 horses horse NNS cord-023095-4dannjjm 942 8 with with IN cord-023095-4dannjjm 942 9 increasing increase VBG cord-023095-4dannjjm 942 10 body body NN cord-023095-4dannjjm 942 11 condition condition NN cord-023095-4dannjjm 942 12 score score NN cord-023095-4dannjjm 942 13 is be VBZ cord-023095-4dannjjm 942 14 unexpected unexpected JJ cord-023095-4dannjjm 942 15 , , , cord-023095-4dannjjm 942 16 and and CC cord-023095-4dannjjm 942 17 may may MD cord-023095-4dannjjm 942 18 indicate indicate VB cord-023095-4dannjjm 942 19 a a DT cord-023095-4dannjjm 942 20 compensatory compensatory JJ cord-023095-4dannjjm 942 21 response response NN cord-023095-4dannjjm 942 22 to to IN cord-023095-4dannjjm 942 23 dysfunction dysfunction NN cord-023095-4dannjjm 942 24 of of IN cord-023095-4dannjjm 942 25 a a DT cord-023095-4dannjjm 942 26 downstream downstream JJ cord-023095-4dannjjm 942 27 pathway pathway NN cord-023095-4dannjjm 942 28 . . . cord-023095-4dannjjm 943 1 Further further JJ cord-023095-4dannjjm 943 2 studies study NNS cord-023095-4dannjjm 943 3 to to TO cord-023095-4dannjjm 943 4 better better RB cord-023095-4dannjjm 943 5 define define VB cord-023095-4dannjjm 943 6 the the DT cord-023095-4dannjjm 943 7 role role NN cord-023095-4dannjjm 943 8 of of IN cord-023095-4dannjjm 943 9 metabolic metabolic JJ cord-023095-4dannjjm 943 10 regulatory regulatory JJ cord-023095-4dannjjm 943 11 gene gene NN cord-023095-4dannjjm 943 12 expression expression NN cord-023095-4dannjjm 943 13 in in IN cord-023095-4dannjjm 943 14 obese obese JJ cord-023095-4dannjjm 943 15 horses horse NNS cord-023095-4dannjjm 943 16 and and CC cord-023095-4dannjjm 943 17 those those DT cord-023095-4dannjjm 943 18 with with IN cord-023095-4dannjjm 943 19 EMS EMS NNP cord-023095-4dannjjm 943 20 are be VBP cord-023095-4dannjjm 943 21 ongoing ongoing JJ cord-023095-4dannjjm 943 22 . . . cord-023095-4dannjjm 944 1 Previously previously RB cord-023095-4dannjjm 944 2 presented present VBN cord-023095-4dannjjm 944 3 at at IN cord-023095-4dannjjm 944 4 the the DT cord-023095-4dannjjm 944 5 7th 7th JJ cord-023095-4dannjjm 944 6 Annual Annual NNP cord-023095-4dannjjm 944 7 Harold Harold NNP cord-023095-4dannjjm 944 8 Hamm Hamm NNP cord-023095-4dannjjm 944 9 Diabetes diabete VBZ cord-023095-4dannjjm 944 10 Center Center NNP cord-023095-4dannjjm 944 11 Research Research NNP cord-023095-4dannjjm 944 12 Retreat Retreat NNP cord-023095-4dannjjm 944 13 , , , cord-023095-4dannjjm 944 14 Oklahoma Oklahoma NNP cord-023095-4dannjjm 944 15 City City NNP cord-023095-4dannjjm 944 16 , , , cord-023095-4dannjjm 944 17 OK ok UH cord-023095-4dannjjm 944 18 . . . cord-023095-4dannjjm 945 1 Inflammatory inflammatory JJ cord-023095-4dannjjm 945 2 bowel bowel NN cord-023095-4dannjjm 945 3 disease disease NN cord-023095-4dannjjm 945 4 is be VBZ cord-023095-4dannjjm 945 5 a a DT cord-023095-4dannjjm 945 6 cause cause NN cord-023095-4dannjjm 945 7 of of IN cord-023095-4dannjjm 945 8 weight weight NN cord-023095-4dannjjm 945 9 loss loss NN cord-023095-4dannjjm 945 10 , , , cord-023095-4dannjjm 945 11 decreased decrease VBD cord-023095-4dannjjm 945 12 performance performance NN cord-023095-4dannjjm 945 13 , , , cord-023095-4dannjjm 945 14 and and CC cord-023095-4dannjjm 945 15 colic colic NN cord-023095-4dannjjm 945 16 in in IN cord-023095-4dannjjm 945 17 horses horse NNS cord-023095-4dannjjm 945 18 . . . cord-023095-4dannjjm 946 1 This this DT cord-023095-4dannjjm 946 2 condition condition NN cord-023095-4dannjjm 946 3 is be VBZ cord-023095-4dannjjm 946 4 difficult difficult JJ cord-023095-4dannjjm 946 5 to to TO cord-023095-4dannjjm 946 6 diagnose diagnose VB cord-023095-4dannjjm 946 7 and and CC cord-023095-4dannjjm 946 8 clinicians clinician NNS cord-023095-4dannjjm 946 9 rely rely VBP cord-023095-4dannjjm 946 10 upon upon IN cord-023095-4dannjjm 946 11 absorption absorption NN cord-023095-4dannjjm 946 12 tests test NNS cord-023095-4dannjjm 946 13 to to TO cord-023095-4dannjjm 946 14 document document VB cord-023095-4dannjjm 946 15 malabsorption malabsorption NN cord-023095-4dannjjm 946 16 . . . cord-023095-4dannjjm 947 1 The the DT cord-023095-4dannjjm 947 2 purpose purpose NN cord-023095-4dannjjm 947 3 of of IN cord-023095-4dannjjm 947 4 this this DT cord-023095-4dannjjm 947 5 study study NN cord-023095-4dannjjm 947 6 was be VBD cord-023095-4dannjjm 947 7 to to TO cord-023095-4dannjjm 947 8 compare compare VB cord-023095-4dannjjm 947 9 glucose glucose NN cord-023095-4dannjjm 947 10 and and CC cord-023095-4dannjjm 947 11 xylose xylose NN cord-023095-4dannjjm 947 12 absorption absorption NN cord-023095-4dannjjm 947 13 tests test NNS cord-023095-4dannjjm 947 14 in in IN cord-023095-4dannjjm 947 15 normal normal JJ cord-023095-4dannjjm 947 16 horses horse NNS cord-023095-4dannjjm 947 17 and and CC cord-023095-4dannjjm 947 18 determine determine VB cord-023095-4dannjjm 947 19 the the DT cord-023095-4dannjjm 947 20 repeatability repeatability NN cord-023095-4dannjjm 947 21 of of IN cord-023095-4dannjjm 947 22 these these DT cord-023095-4dannjjm 947 23 procedures procedure NNS cord-023095-4dannjjm 947 24 . . . cord-023095-4dannjjm 948 1 Eight eight CD cord-023095-4dannjjm 948 2 horses horse NNS cord-023095-4dannjjm 948 3 received receive VBD cord-023095-4dannjjm 948 4 500 500 CD cord-023095-4dannjjm 948 5 mg mg NNP cord-023095-4dannjjm 948 6 / / SYM cord-023095-4dannjjm 948 7 kg kg NNS cord-023095-4dannjjm 948 8 dextrose dextrose NN cord-023095-4dannjjm 948 9 or or CC cord-023095-4dannjjm 948 10 D d NN cord-023095-4dannjjm 948 11 - - HYPH cord-023095-4dannjjm 948 12 xylose xylose NN cord-023095-4dannjjm 948 13 powder powder NN cord-023095-4dannjjm 948 14 mixed mix VBN cord-023095-4dannjjm 948 15 as as IN cord-023095-4dannjjm 948 16 a a DT cord-023095-4dannjjm 948 17 10 10 CD cord-023095-4dannjjm 948 18 % % NN cord-023095-4dannjjm 948 19 solution solution NN cord-023095-4dannjjm 948 20 in in IN cord-023095-4dannjjm 948 21 water water NN cord-023095-4dannjjm 948 22 or or CC cord-023095-4dannjjm 948 23 water water NN cord-023095-4dannjjm 948 24 alone alone RB cord-023095-4dannjjm 948 25 via via IN cord-023095-4dannjjm 948 26 nasogastric nasogastric NN cord-023095-4dannjjm 948 27 intubation intubation NN cord-023095-4dannjjm 948 28 on on IN cord-023095-4dannjjm 948 29 three three CD cord-023095-4dannjjm 948 30 different different JJ cord-023095-4dannjjm 948 31 occasions occasion NNS cord-023095-4dannjjm 948 32 within within IN cord-023095-4dannjjm 948 33 the the DT cord-023095-4dannjjm 948 34 same same JJ cord-023095-4dannjjm 948 35 week week NN cord-023095-4dannjjm 948 36 for for IN cord-023095-4dannjjm 948 37 three three CD cord-023095-4dannjjm 948 38 consecutive consecutive JJ cord-023095-4dannjjm 948 39 weeks week NNS cord-023095-4dannjjm 948 40 ( ( -LRB- cord-023095-4dannjjm 948 41 9 9 CD cord-023095-4dannjjm 948 42 tests test NNS cord-023095-4dannjjm 948 43 / / SYM cord-023095-4dannjjm 948 44 horse horse NN cord-023095-4dannjjm 948 45 ) ) -RRB- cord-023095-4dannjjm 948 46 . . . cord-023095-4dannjjm 949 1 A a DT cord-023095-4dannjjm 949 2 crossover crossover NN cord-023095-4dannjjm 949 3 design design NN cord-023095-4dannjjm 949 4 was be VBD cord-023095-4dannjjm 949 5 employed employ VBN cord-023095-4dannjjm 949 6 and and CC cord-023095-4dannjjm 949 7 the the DT cord-023095-4dannjjm 949 8 order order NN cord-023095-4dannjjm 949 9 of of IN cord-023095-4dannjjm 949 10 treatments treatment NNS cord-023095-4dannjjm 949 11 was be VBD cord-023095-4dannjjm 949 12 randomized randomize VBN cord-023095-4dannjjm 949 13 . . . cord-023095-4dannjjm 950 1 Blood blood NN cord-023095-4dannjjm 950 2 samples sample NNS cord-023095-4dannjjm 950 3 were be VBD cord-023095-4dannjjm 950 4 collected collect VBN cord-023095-4dannjjm 950 5 at at IN cord-023095-4dannjjm 950 6 time time NN cord-023095-4dannjjm 950 7 5 5 CD cord-023095-4dannjjm 950 8 0 0 CD cord-023095-4dannjjm 950 9 , , , cord-023095-4dannjjm 950 10 30 30 CD cord-023095-4dannjjm 950 11 , , , cord-023095-4dannjjm 950 12 60 60 CD cord-023095-4dannjjm 950 13 , , , cord-023095-4dannjjm 950 14 90 90 CD cord-023095-4dannjjm 950 15 , , , cord-023095-4dannjjm 950 16 120 120 CD cord-023095-4dannjjm 950 17 , , , cord-023095-4dannjjm 950 18 150 150 CD cord-023095-4dannjjm 950 19 , , , cord-023095-4dannjjm 950 20 and and CC cord-023095-4dannjjm 950 21 180 180 CD cord-023095-4dannjjm 950 22 min min NN cord-023095-4dannjjm 950 23 . . . cord-023095-4dannjjm 951 1 Data datum NNS cord-023095-4dannjjm 951 2 were be VBD cord-023095-4dannjjm 951 3 analyzed analyze VBN cord-023095-4dannjjm 951 4 by by IN cord-023095-4dannjjm 951 5 repeated repeat VBN cord-023095-4dannjjm 951 6 measures measure NNS cord-023095-4dannjjm 951 7 ANOVA ANOVA NNP cord-023095-4dannjjm 951 8 and and CC cord-023095-4dannjjm 951 9 t t NN cord-023095-4dannjjm 951 10 - - HYPH cord-023095-4dannjjm 951 11 tests test NNS cord-023095-4dannjjm 951 12 . . . cord-023095-4dannjjm 952 1 Results result NNS cord-023095-4dannjjm 952 2 showed show VBD cord-023095-4dannjjm 952 3 that that IN cord-023095-4dannjjm 952 4 the the DT cord-023095-4dannjjm 952 5 xylose xylose NN cord-023095-4dannjjm 952 6 response response NN cord-023095-4dannjjm 952 7 over over IN cord-023095-4dannjjm 952 8 time time NN cord-023095-4dannjjm 952 9 differed differ VBD cord-023095-4dannjjm 952 10 significantly significantly RB cord-023095-4dannjjm 952 11 from from IN cord-023095-4dannjjm 952 12 the the DT cord-023095-4dannjjm 952 13 glucose glucose NN cord-023095-4dannjjm 952 14 response response NN cord-023095-4dannjjm 952 15 over over IN cord-023095-4dannjjm 952 16 time time NN cord-023095-4dannjjm 952 17 ( ( -LRB- cord-023095-4dannjjm 952 18 test test NN cord-023095-4dannjjm 952 19 Â â CD cord-023095-4dannjjm 952 20 time time NN cord-023095-4dannjjm 952 21 ; ; : cord-023095-4dannjjm 952 22 P p NN cord-023095-4dannjjm 952 23 o o NN cord-023095-4dannjjm 952 24 0.001 0.001 CD cord-023095-4dannjjm 952 25 ) ) -RRB- cord-023095-4dannjjm 952 26 . . . cord-023095-4dannjjm 953 1 Mean mean JJ cord-023095-4dannjjm 953 2 time time NN cord-023095-4dannjjm 953 3 to to TO cord-023095-4dannjjm 953 4 maximum maximum VB cord-023095-4dannjjm 953 5 concentration concentration NN cord-023095-4dannjjm 953 6 differed differ VBD cord-023095-4dannjjm 953 7 ( ( -LRB- cord-023095-4dannjjm 953 8 P p NN cord-023095-4dannjjm 953 9 o o NN cord-023095-4dannjjm 953 10 0.001 0.001 CD cord-023095-4dannjjm 953 11 ) ) -RRB- cord-023095-4dannjjm 953 12 between between IN cord-023095-4dannjjm 953 13 tests test NNS cord-023095-4dannjjm 953 14 ( ( -LRB- cord-023095-4dannjjm 953 15 glucose glucose NN cord-023095-4dannjjm 953 16 90 90 CD cord-023095-4dannjjm 953 17 min min NN cord-023095-4dannjjm 953 18 ; ; : cord-023095-4dannjjm 953 19 xylose xylose NNP cord-023095-4dannjjm 953 20 60 60 CD cord-023095-4dannjjm 953 21 min min NN cord-023095-4dannjjm 953 22 ) ) -RRB- cord-023095-4dannjjm 953 23 . . . cord-023095-4dannjjm 954 1 Within within IN cord-023095-4dannjjm 954 2 - - HYPH cord-023095-4dannjjm 954 3 horse horse NN cord-023095-4dannjjm 954 4 area area NN cord-023095-4dannjjm 954 5 under under IN cord-023095-4dannjjm 954 6 the the DT cord-023095-4dannjjm 954 7 curve curve NN cord-023095-4dannjjm 954 8 , , , cord-023095-4dannjjm 954 9 maximum maximum JJ cord-023095-4dannjjm 954 10 concentration concentration NN cord-023095-4dannjjm 954 11 , , , cord-023095-4dannjjm 954 12 and and CC cord-023095-4dannjjm 954 13 time time NN cord-023095-4dannjjm 954 14 to to TO cord-023095-4dannjjm 954 15 maximum maximum VB cord-023095-4dannjjm 954 16 concentration concentration NN cord-023095-4dannjjm 954 17 values value NNS cord-023095-4dannjjm 954 18 for for IN cord-023095-4dannjjm 954 19 dextrose dextrose NN cord-023095-4dannjjm 954 20 and and CC cord-023095-4dannjjm 954 21 xylose xylose NNP cord-023095-4dannjjm 954 22 did do VBD cord-023095-4dannjjm 954 23 not not RB cord-023095-4dannjjm 954 24 differ differ VB cord-023095-4dannjjm 954 25 significantly significantly RB cord-023095-4dannjjm 954 26 when when WRB cord-023095-4dannjjm 954 27 tests test NNS cord-023095-4dannjjm 954 28 were be VBD cord-023095-4dannjjm 954 29 repeated repeat VBN cord-023095-4dannjjm 954 30 . . . cord-023095-4dannjjm 955 1 Results result NNS cord-023095-4dannjjm 955 2 indicate indicate VBP cord-023095-4dannjjm 955 3 that that IN cord-023095-4dannjjm 955 4 glucose glucose NN cord-023095-4dannjjm 955 5 and and CC cord-023095-4dannjjm 955 6 xylose xylose NN cord-023095-4dannjjm 955 7 absorption absorption NN cord-023095-4dannjjm 955 8 tests test NNS cord-023095-4dannjjm 955 9 are be VBP cord-023095-4dannjjm 955 10 repeatable repeatable JJ cord-023095-4dannjjm 955 11 within within IN cord-023095-4dannjjm 955 12 the the DT cord-023095-4dannjjm 955 13 same same JJ cord-023095-4dannjjm 955 14 horse horse NN cord-023095-4dannjjm 955 15 , , , cord-023095-4dannjjm 955 16 but but CC cord-023095-4dannjjm 955 17 plotted plot VBN cord-023095-4dannjjm 955 18 curves curve NNS cord-023095-4dannjjm 955 19 differ differ VBP cord-023095-4dannjjm 955 20 between between IN cord-023095-4dannjjm 955 21 tests test NNS cord-023095-4dannjjm 955 22 , , , cord-023095-4dannjjm 955 23 with with IN cord-023095-4dannjjm 955 24 peak peak NN cord-023095-4dannjjm 955 25 concentrations concentration NNS cord-023095-4dannjjm 955 26 occurring occur VBG cord-023095-4dannjjm 955 27 at at IN cord-023095-4dannjjm 955 28 a a DT cord-023095-4dannjjm 955 29 later later JJ cord-023095-4dannjjm 955 30 time time NN cord-023095-4dannjjm 955 31 point point NN cord-023095-4dannjjm 955 32 for for IN cord-023095-4dannjjm 955 33 the the DT cord-023095-4dannjjm 955 34 glucose glucose NN cord-023095-4dannjjm 955 35 absorption absorption NN cord-023095-4dannjjm 955 36 test test NN cord-023095-4dannjjm 955 37 . . . cord-023095-4dannjjm 956 1 We -PRON- PRP cord-023095-4dannjjm 956 2 conclude conclude VBP cord-023095-4dannjjm 956 3 that that IN cord-023095-4dannjjm 956 4 both both DT cord-023095-4dannjjm 956 5 tests test NNS cord-023095-4dannjjm 956 6 provide provide VBP cord-023095-4dannjjm 956 7 repeatable repeatable JJ cord-023095-4dannjjm 956 8 measures measure NNS cord-023095-4dannjjm 956 9 of of IN cord-023095-4dannjjm 956 10 intestinal intestinal JJ cord-023095-4dannjjm 956 11 absorption absorption NN cord-023095-4dannjjm 956 12 , , , cord-023095-4dannjjm 956 13 but but CC cord-023095-4dannjjm 956 14 glucose glucose NN cord-023095-4dannjjm 956 15 and and CC cord-023095-4dannjjm 956 16 xylose xylose NN cord-023095-4dannjjm 956 17 appear appear VBP cord-023095-4dannjjm 956 18 to to TO cord-023095-4dannjjm 956 19 differ differ VB cord-023095-4dannjjm 956 20 in in IN cord-023095-4dannjjm 956 21 their -PRON- PRP$ cord-023095-4dannjjm 956 22 rates rate NNS cord-023095-4dannjjm 956 23 of of IN cord-023095-4dannjjm 956 24 absorption absorption NN cord-023095-4dannjjm 956 25 and and CC cord-023095-4dannjjm 956 26 clearance clearance NN cord-023095-4dannjjm 956 27 . . . cord-023095-4dannjjm 957 1 The the DT cord-023095-4dannjjm 957 2 purpose purpose NN cord-023095-4dannjjm 957 3 of of IN cord-023095-4dannjjm 957 4 this this DT cord-023095-4dannjjm 957 5 study study NN cord-023095-4dannjjm 957 6 was be VBD cord-023095-4dannjjm 957 7 to to TO cord-023095-4dannjjm 957 8 examine examine VB cord-023095-4dannjjm 957 9 the the DT cord-023095-4dannjjm 957 10 records record NNS cord-023095-4dannjjm 957 11 of of IN cord-023095-4dannjjm 957 12 a a DT cord-023095-4dannjjm 957 13 population population NN cord-023095-4dannjjm 957 14 of of IN cord-023095-4dannjjm 957 15 Thoroughbreds Thoroughbreds NNPS cord-023095-4dannjjm 957 16 with with IN cord-023095-4dannjjm 957 17 cervical cervical JJ cord-023095-4dannjjm 957 18 vertebral vertebral JJ cord-023095-4dannjjm 957 19 malformation malformation NN cord-023095-4dannjjm 957 20 ( ( -LRB- cord-023095-4dannjjm 957 21 CVM CVM NNP cord-023095-4dannjjm 957 22 ) ) -RRB- cord-023095-4dannjjm 957 23 and and CC cord-023095-4dannjjm 957 24 to to TO cord-023095-4dannjjm 957 25 determine determine VB cord-023095-4dannjjm 957 26 which which WDT cord-023095-4dannjjm 957 27 factors factor NNS cord-023095-4dannjjm 957 28 have have VBP cord-023095-4dannjjm 957 29 an an DT cord-023095-4dannjjm 957 30 effect effect NN cord-023095-4dannjjm 957 31 on on IN cord-023095-4dannjjm 957 32 these these DT cord-023095-4dannjjm 957 33 horses horse NNS cord-023095-4dannjjm 957 34 achieving achieve VBG cord-023095-4dannjjm 957 35 athletic athletic JJ cord-023095-4dannjjm 957 36 function function NN cord-023095-4dannjjm 957 37 . . . cord-023095-4dannjjm 958 1 This this DT cord-023095-4dannjjm 958 2 was be VBD cord-023095-4dannjjm 958 3 a a DT cord-023095-4dannjjm 958 4 retrospective retrospective JJ cord-023095-4dannjjm 958 5 case case NN cord-023095-4dannjjm 958 6 study study NN cord-023095-4dannjjm 958 7 of of IN cord-023095-4dannjjm 958 8 119 119 CD cord-023095-4dannjjm 958 9 Thoroughbreds Thoroughbreds NNPS cord-023095-4dannjjm 958 10 with with IN cord-023095-4dannjjm 958 11 CVM CVM NNP cord-023095-4dannjjm 958 12 treated treat VBD cord-023095-4dannjjm 958 13 medically medically RB cord-023095-4dannjjm 958 14 from from IN cord-023095-4dannjjm 958 15 2002 2002 CD cord-023095-4dannjjm 958 16 to to IN cord-023095-4dannjjm 958 17 2010 2010 CD cord-023095-4dannjjm 958 18 . . . cord-023095-4dannjjm 959 1 Forty forty CD cord-023095-4dannjjm 959 2 - - HYPH cord-023095-4dannjjm 959 3 one one CD cord-023095-4dannjjm 959 4 were be VBD cord-023095-4dannjjm 959 5 euthanized euthanize VBN cord-023095-4dannjjm 959 6 after after IN cord-023095-4dannjjm 959 7 diagnosis diagnosis NN cord-023095-4dannjjm 959 8 , , , cord-023095-4dannjjm 959 9 while while IN cord-023095-4dannjjm 959 10 the the DT cord-023095-4dannjjm 959 11 remaining remain VBG cord-023095-4dannjjm 959 12 78 78 CD cord-023095-4dannjjm 959 13 were be VBD cord-023095-4dannjjm 959 14 discharged discharge VBN cord-023095-4dannjjm 959 15 for for IN cord-023095-4dannjjm 959 16 treatment treatment NN cord-023095-4dannjjm 959 17 . . . cord-023095-4dannjjm 960 1 Racing racing NN cord-023095-4dannjjm 960 2 records record NNS cord-023095-4dannjjm 960 3 were be VBD cord-023095-4dannjjm 960 4 reviewed review VBN cord-023095-4dannjjm 960 5 to to TO cord-023095-4dannjjm 960 6 determine determine VB cord-023095-4dannjjm 960 7 which which WDT cord-023095-4dannjjm 960 8 horses horse NNS cord-023095-4dannjjm 960 9 raced race VBD cord-023095-4dannjjm 960 10 after after IN cord-023095-4dannjjm 960 11 treatment treatment NN cord-023095-4dannjjm 960 12 . . . cord-023095-4dannjjm 961 1 Horses horse NNS cord-023095-4dannjjm 961 2 were be VBD cord-023095-4dannjjm 961 3 separated separate VBN cord-023095-4dannjjm 961 4 into into IN cord-023095-4dannjjm 961 5 groups group NNS cord-023095-4dannjjm 961 6 based base VBN cord-023095-4dannjjm 961 7 on on IN cord-023095-4dannjjm 961 8 whether whether IN cord-023095-4dannjjm 961 9 or or CC cord-023095-4dannjjm 961 10 not not RB cord-023095-4dannjjm 961 11 they -PRON- PRP cord-023095-4dannjjm 961 12 raced race VBD cord-023095-4dannjjm 961 13 . . . cord-023095-4dannjjm 962 1 Medical medical JJ cord-023095-4dannjjm 962 2 records record NNS cord-023095-4dannjjm 962 3 were be VBD cord-023095-4dannjjm 962 4 reviewed review VBN cord-023095-4dannjjm 962 5 , , , cord-023095-4dannjjm 962 6 and and CC cord-023095-4dannjjm 962 7 results result NNS cord-023095-4dannjjm 962 8 of of IN cord-023095-4dannjjm 962 9 neurologic neurologic JJ cord-023095-4dannjjm 962 10 examination examination NN cord-023095-4dannjjm 962 11 , , , cord-023095-4dannjjm 962 12 radiographic radiographic JJ cord-023095-4dannjjm 962 13 and and CC cord-023095-4dannjjm 962 14 laboratory laboratory NN cord-023095-4dannjjm 962 15 findings finding NNS cord-023095-4dannjjm 962 16 , , , cord-023095-4dannjjm 962 17 treatments treatment NNS cord-023095-4dannjjm 962 18 , , , cord-023095-4dannjjm 962 19 and and CC cord-023095-4dannjjm 962 20 outcome outcome NN cord-023095-4dannjjm 962 21 were be VBD cord-023095-4dannjjm 962 22 assessed assess VBN cord-023095-4dannjjm 962 23 and and CC cord-023095-4dannjjm 962 24 compared compare VBN cord-023095-4dannjjm 962 25 between between IN cord-023095-4dannjjm 962 26 groups group NNS cord-023095-4dannjjm 962 27 . . . cord-023095-4dannjjm 963 1 Twenty twenty CD cord-023095-4dannjjm 963 2 - - HYPH cord-023095-4dannjjm 963 3 one one CD cord-023095-4dannjjm 963 4 of of IN cord-023095-4dannjjm 963 5 78 78 CD cord-023095-4dannjjm 963 6 horses horse NNS cord-023095-4dannjjm 963 7 treated treat VBN cord-023095-4dannjjm 963 8 medically medically RB cord-023095-4dannjjm 963 9 ( ( -LRB- cord-023095-4dannjjm 963 10 27 27 CD cord-023095-4dannjjm 963 11 % % NN cord-023095-4dannjjm 963 12 ) ) -RRB- cord-023095-4dannjjm 963 13 improved improve VBN cord-023095-4dannjjm 963 14 enough enough RB cord-023095-4dannjjm 963 15 to to TO cord-023095-4dannjjm 963 16 race race VB cord-023095-4dannjjm 963 17 . . . cord-023095-4dannjjm 964 1 Median median JJ cord-023095-4dannjjm 964 2 neurologic neurologic JJ cord-023095-4dannjjm 964 3 grade grade NN cord-023095-4dannjjm 964 4 between between IN cord-023095-4dannjjm 964 5 groups group NNS cord-023095-4dannjjm 964 6 was be VBD cord-023095-4dannjjm 964 7 significantly significantly RB cord-023095-4dannjjm 964 8 different different JJ cord-023095-4dannjjm 964 9 ( ( -LRB- cord-023095-4dannjjm 964 10 p p NN cord-023095-4dannjjm 964 11 o o CD cord-023095-4dannjjm 964 12 0.0001 0.0001 CD cord-023095-4dannjjm 964 13 ) ) -RRB- cord-023095-4dannjjm 964 14 , , , cord-023095-4dannjjm 964 15 with with IN cord-023095-4dannjjm 964 16 a a DT cord-023095-4dannjjm 964 17 hind hind NN cord-023095-4dannjjm 964 18 limb limb NN cord-023095-4dannjjm 964 19 grade grade NN cord-023095-4dannjjm 964 20 of of IN cord-023095-4dannjjm 964 21 2.0 2.0 CD cord-023095-4dannjjm 964 22 ( ( -LRB- cord-023095-4dannjjm 964 23 range range NNP cord-023095-4dannjjm 964 24 1 1 CD cord-023095-4dannjjm 964 25 - - SYM cord-023095-4dannjjm 964 26 3 3 CD cord-023095-4dannjjm 964 27 ) ) -RRB- cord-023095-4dannjjm 964 28 for for IN cord-023095-4dannjjm 964 29 the the DT cord-023095-4dannjjm 964 30 raced race VBN cord-023095-4dannjjm 964 31 group group NN cord-023095-4dannjjm 964 32 and and CC cord-023095-4dannjjm 964 33 2.5 2.5 CD cord-023095-4dannjjm 964 34 ( ( -LRB- cord-023095-4dannjjm 964 35 range range VBP cord-023095-4dannjjm 964 36 0.5 0.5 CD cord-023095-4dannjjm 964 37 - - SYM cord-023095-4dannjjm 964 38 4 4 CD cord-023095-4dannjjm 964 39 ) ) -RRB- cord-023095-4dannjjm 964 40 for for IN cord-023095-4dannjjm 964 41 the the DT cord-023095-4dannjjm 964 42 unraced unraced JJ cord-023095-4dannjjm 964 43 . . . cord-023095-4dannjjm 965 1 Intravertebral intravertebral JJ cord-023095-4dannjjm 965 2 sagittal sagittal JJ cord-023095-4dannjjm 965 3 ratios ratio NNS cord-023095-4dannjjm 965 4 measured measure VBN cord-023095-4dannjjm 965 5 from from IN cord-023095-4dannjjm 965 6 standing stand VBG cord-023095-4dannjjm 965 7 lateral lateral JJ cord-023095-4dannjjm 965 8 cervical cervical JJ cord-023095-4dannjjm 965 9 radiographs radiograph NNS cord-023095-4dannjjm 965 10 were be VBD cord-023095-4dannjjm 965 11 equivocal equivocal JJ cord-023095-4dannjjm 965 12 between between IN cord-023095-4dannjjm 965 13 groups group NNS cord-023095-4dannjjm 965 14 . . . cord-023095-4dannjjm 966 1 Radiographs radiograph NNS cord-023095-4dannjjm 966 2 of of IN cord-023095-4dannjjm 966 3 all all DT cord-023095-4dannjjm 966 4 horses horse NNS cord-023095-4dannjjm 966 5 were be VBD cord-023095-4dannjjm 966 6 examined examine VBN cord-023095-4dannjjm 966 7 for for IN cord-023095-4dannjjm 966 8 kyphosis kyphosis NN cord-023095-4dannjjm 966 9 , , , cord-023095-4dannjjm 966 10 dorsal dorsal JJ cord-023095-4dannjjm 966 11 over over IN cord-023095-4dannjjm 966 12 - - HYPH cord-023095-4dannjjm 966 13 riding riding NN cord-023095-4dannjjm 966 14 arch arch NN cord-023095-4dannjjm 966 15 , , , cord-023095-4dannjjm 966 16 caudal caudal JJ cord-023095-4dannjjm 966 17 epiphysitis epiphysitis NN cord-023095-4dannjjm 966 18 , , , cord-023095-4dannjjm 966 19 degenerative degenerative JJ cord-023095-4dannjjm 966 20 joint joint JJ cord-023095-4dannjjm 966 21 disease disease NN cord-023095-4dannjjm 966 22 , , , cord-023095-4dannjjm 966 23 cystic cystic JJ cord-023095-4dannjjm 966 24 bone bone NN cord-023095-4dannjjm 966 25 lesions lesion NNS cord-023095-4dannjjm 966 26 , , , cord-023095-4dannjjm 966 27 and and CC cord-023095-4dannjjm 966 28 cranial cranial JJ cord-023095-4dannjjm 966 29 stenosis stenosis NN cord-023095-4dannjjm 966 30 of of IN cord-023095-4dannjjm 966 31 the the DT cord-023095-4dannjjm 966 32 vertebral vertebral JJ cord-023095-4dannjjm 966 33 canal canal NN cord-023095-4dannjjm 966 34 . . . cord-023095-4dannjjm 967 1 Horses horse NNS cord-023095-4dannjjm 967 2 with with IN cord-023095-4dannjjm 967 3 kyphosis kyphosis NN cord-023095-4dannjjm 967 4 ( ( -LRB- cord-023095-4dannjjm 967 5 p p NN cord-023095-4dannjjm 967 6 5 5 CD cord-023095-4dannjjm 967 7 0.0178 0.0178 CD cord-023095-4dannjjm 967 8 ) ) -RRB- cord-023095-4dannjjm 967 9 , , , cord-023095-4dannjjm 967 10 degenerative degenerative JJ cord-023095-4dannjjm 967 11 joint joint JJ cord-023095-4dannjjm 967 12 disease disease NN cord-023095-4dannjjm 967 13 ( ( -LRB- cord-023095-4dannjjm 967 14 p p NN cord-023095-4dannjjm 967 15 5 5 CD cord-023095-4dannjjm 967 16 0.0497 0.0497 CD cord-023095-4dannjjm 967 17 ) ) -RRB- cord-023095-4dannjjm 967 18 , , , cord-023095-4dannjjm 967 19 or or CC cord-023095-4dannjjm 967 20 cranial cranial JJ cord-023095-4dannjjm 967 21 stenosis stenosis NN cord-023095-4dannjjm 968 1 ( ( -LRB- cord-023095-4dannjjm 968 2 p p NN cord-023095-4dannjjm 968 3 5 5 CD cord-023095-4dannjjm 968 4 0.0357 0.0357 CD cord-023095-4dannjjm 968 5 ) ) -RRB- cord-023095-4dannjjm 968 6 at at IN cord-023095-4dannjjm 968 7 any any DT cord-023095-4dannjjm 968 8 site site NN cord-023095-4dannjjm 968 9 were be VBD cord-023095-4dannjjm 968 10 less less RBR cord-023095-4dannjjm 968 11 likely likely JJ cord-023095-4dannjjm 968 12 to to TO cord-023095-4dannjjm 968 13 return return VB cord-023095-4dannjjm 968 14 to to IN cord-023095-4dannjjm 968 15 racing racing NN cord-023095-4dannjjm 968 16 . . . cord-023095-4dannjjm 969 1 Racing race VBG cord-023095-4dannjjm 969 2 prognosis prognosis NN cord-023095-4dannjjm 969 3 for for IN cord-023095-4dannjjm 969 4 horses horse NNS cord-023095-4dannjjm 969 5 with with IN cord-023095-4dannjjm 969 6 CVM CVM NNP cord-023095-4dannjjm 969 7 treated treat VBD cord-023095-4dannjjm 969 8 conservatively conservatively RB cord-023095-4dannjjm 969 9 is be VBZ cord-023095-4dannjjm 969 10 equivalent equivalent JJ cord-023095-4dannjjm 969 11 to to IN cord-023095-4dannjjm 969 12 that that DT cord-023095-4dannjjm 969 13 of of IN cord-023095-4dannjjm 969 14 those those DT cord-023095-4dannjjm 969 15 treated treat VBN cord-023095-4dannjjm 969 16 surgically surgically RB cord-023095-4dannjjm 969 17 as as IN cord-023095-4dannjjm 969 18 reported report VBN cord-023095-4dannjjm 969 19 by by IN cord-023095-4dannjjm 969 20 Rush Rush NNP cord-023095-4dannjjm 969 21 Moore Moore NNP cord-023095-4dannjjm 969 22 et et NNP cord-023095-4dannjjm 969 23 al al NNP cord-023095-4dannjjm 969 24 ( ( -LRB- cord-023095-4dannjjm 969 25 JAVMA JAVMA NNP cord-023095-4dannjjm 969 26 , , , cord-023095-4dannjjm 969 27 1993 1993 CD cord-023095-4dannjjm 969 28 ) ) -RRB- cord-023095-4dannjjm 969 29 . . . cord-023095-4dannjjm 970 1 Radiographic radiographic JJ cord-023095-4dannjjm 970 2 changes change NNS cord-023095-4dannjjm 970 3 and and CC cord-023095-4dannjjm 970 4 neurologic neurologic JJ cord-023095-4dannjjm 970 5 grade grade NN cord-023095-4dannjjm 970 6 may may MD cord-023095-4dannjjm 970 7 help help VB cord-023095-4dannjjm 970 8 serve serve VB cord-023095-4dannjjm 970 9 as as IN cord-023095-4dannjjm 970 10 indicators indicator NNS cord-023095-4dannjjm 970 11 for for IN cord-023095-4dannjjm 970 12 whether whether IN cord-023095-4dannjjm 970 13 a a DT cord-023095-4dannjjm 970 14 horse horse NN cord-023095-4dannjjm 970 15 will will MD cord-023095-4dannjjm 970 16 respond respond VB cord-023095-4dannjjm 970 17 to to IN cord-023095-4dannjjm 970 18 conservative conservative JJ cord-023095-4dannjjm 970 19 therapy therapy NN cord-023095-4dannjjm 970 20 . . . cord-023095-4dannjjm 971 1 Since since IN cord-023095-4dannjjm 971 2 pain pain NN cord-023095-4dannjjm 971 3 assessment assessment NN cord-023095-4dannjjm 971 4 is be VBZ cord-023095-4dannjjm 971 5 vital vital JJ cord-023095-4dannjjm 971 6 for for IN cord-023095-4dannjjm 971 7 management management NN cord-023095-4dannjjm 971 8 of of IN cord-023095-4dannjjm 971 9 colic colic NN cord-023095-4dannjjm 971 10 , , , cord-023095-4dannjjm 971 11 a a DT cord-023095-4dannjjm 971 12 valid valid JJ cord-023095-4dannjjm 971 13 , , , cord-023095-4dannjjm 971 14 reliable reliable JJ cord-023095-4dannjjm 971 15 and and CC cord-023095-4dannjjm 971 16 feasible feasible JJ cord-023095-4dannjjm 971 17 tool tool NN cord-023095-4dannjjm 971 18 for for IN cord-023095-4dannjjm 971 19 assessing assess VBG cord-023095-4dannjjm 971 20 the the DT cord-023095-4dannjjm 971 21 severity severity NN cord-023095-4dannjjm 971 22 of of IN cord-023095-4dannjjm 971 23 acute acute JJ cord-023095-4dannjjm 971 24 abdominal abdominal JJ cord-023095-4dannjjm 971 25 pain pain NN cord-023095-4dannjjm 971 26 in in IN cord-023095-4dannjjm 971 27 horses horse NNS cord-023095-4dannjjm 971 28 is be VBZ cord-023095-4dannjjm 971 29 urgently urgently RB cord-023095-4dannjjm 971 30 needed need VBN cord-023095-4dannjjm 971 31 . . . cord-023095-4dannjjm 972 1 Our -PRON- PRP$ cord-023095-4dannjjm 972 2 aim aim NN cord-023095-4dannjjm 972 3 was be VBD cord-023095-4dannjjm 972 4 to to TO cord-023095-4dannjjm 972 5 construct construct VB cord-023095-4dannjjm 972 6 and and CC cord-023095-4dannjjm 972 7 validate validate VB cord-023095-4dannjjm 972 8 a a DT cord-023095-4dannjjm 972 9 behavior behavior NN cord-023095-4dannjjm 972 10 - - HYPH cord-023095-4dannjjm 972 11 based base VBN cord-023095-4dannjjm 972 12 pain pain NN cord-023095-4dannjjm 972 13 scale scale NN cord-023095-4dannjjm 972 14 by by IN cord-023095-4dannjjm 972 15 methodology methodology NN cord-023095-4dannjjm 972 16 utilized utilize VBN cord-023095-4dannjjm 972 17 in in IN cord-023095-4dannjjm 972 18 construction construction NN cord-023095-4dannjjm 972 19 of of IN cord-023095-4dannjjm 972 20 pain pain NN cord-023095-4dannjjm 972 21 scales scale NNS cord-023095-4dannjjm 972 22 in in IN cord-023095-4dannjjm 972 23 non non JJ cord-023095-4dannjjm 972 24 - - JJ cord-023095-4dannjjm 972 25 verbal verbal JJ cord-023095-4dannjjm 972 26 humans human NNS cord-023095-4dannjjm 972 27 . . . cord-023095-4dannjjm 973 1 The the DT cord-023095-4dannjjm 973 2 project project NN cord-023095-4dannjjm 973 3 consisted consist VBD cord-023095-4dannjjm 973 4 of of IN cord-023095-4dannjjm 973 5 four four CD cord-023095-4dannjjm 973 6 stages stage NNS cord-023095-4dannjjm 973 7 . . . cord-023095-4dannjjm 974 1 Firstly firstly RB cord-023095-4dannjjm 974 2 , , , cord-023095-4dannjjm 974 3 behaviors behavior NNS cord-023095-4dannjjm 974 4 to to TO cord-023095-4dannjjm 974 5 include include VB cord-023095-4dannjjm 974 6 in in IN cord-023095-4dannjjm 974 7 a a DT cord-023095-4dannjjm 974 8 scale scale NN cord-023095-4dannjjm 974 9 were be VBD cord-023095-4dannjjm 974 10 empirically empirically RB cord-023095-4dannjjm 974 11 identified identify VBN cord-023095-4dannjjm 974 12 . . . cord-023095-4dannjjm 975 1 Thirty thirty CD cord-023095-4dannjjm 975 2 equine equine JJ cord-023095-4dannjjm 975 3 clinicians clinician NNS cord-023095-4dannjjm 975 4 noted note VBD cord-023095-4dannjjm 975 5 behaviors behavior NNS cord-023095-4dannjjm 975 6 in in IN cord-023095-4dannjjm 975 7 each each DT cord-023095-4dannjjm 975 8 of of IN cord-023095-4dannjjm 975 9 23 23 CD cord-023095-4dannjjm 975 10 random random JJ cord-023095-4dannjjm 975 11 film film NN cord-023095-4dannjjm 975 12 clips clip NNS cord-023095-4dannjjm 975 13 of of IN cord-023095-4dannjjm 975 14 horses horse NNS cord-023095-4dannjjm 975 15 with with IN cord-023095-4dannjjm 975 16 colic colic NN cord-023095-4dannjjm 975 17 using use VBG cord-023095-4dannjjm 975 18 a a DT cord-023095-4dannjjm 975 19 checklist checklist NN cord-023095-4dannjjm 975 20 . . . cord-023095-4dannjjm 976 1 Nine nine CD cord-023095-4dannjjm 976 2 behaviors behavior NNS cord-023095-4dannjjm 976 3 ( ( -LRB- cord-023095-4dannjjm 976 4 e.g. e.g. RB cord-023095-4dannjjm 976 5 rolling roll VBG cord-023095-4dannjjm 976 6 , , , cord-023095-4dannjjm 976 7 pawing paw VBG cord-023095-4dannjjm 976 8 , , , cord-023095-4dannjjm 976 9 and and CC cord-023095-4dannjjm 976 10 flank flank VB cord-023095-4dannjjm 976 11 watching watch VBG cord-023095-4dannjjm 976 12 ) ) -RRB- cord-023095-4dannjjm 976 13 demonstrated demonstrate VBN cord-023095-4dannjjm 976 14 good good JJ cord-023095-4dannjjm 976 15 inter inter JJ cord-023095-4dannjjm 976 16 - - JJ cord-023095-4dannjjm 976 17 observer observer JJ cord-023095-4dannjjm 976 18 agreement agreement NN cord-023095-4dannjjm 976 19 without without IN cord-023095-4dannjjm 976 20 bias bias NN cord-023095-4dannjjm 976 21 ( ( -LRB- cord-023095-4dannjjm 976 22 multi multi JJ cord-023095-4dannjjm 976 23 - - JJ cord-023095-4dannjjm 976 24 rater rater JJ cord-023095-4dannjjm 976 25 kappas kappa NNS cord-023095-4dannjjm 976 26 : : : cord-023095-4dannjjm 976 27 0.5 0.5 CD cord-023095-4dannjjm 976 28 - - HYPH cord-023095-4dannjjm 976 29 0.95 0.95 CD cord-023095-4dannjjm 976 30 ) ) -RRB- cord-023095-4dannjjm 976 31 . . . cord-023095-4dannjjm 977 1 Secondly secondly RB cord-023095-4dannjjm 977 2 , , , cord-023095-4dannjjm 977 3 the the DT cord-023095-4dannjjm 977 4 clinical clinical JJ cord-023095-4dannjjm 977 5 judgment judgment NN cord-023095-4dannjjm 977 6 of of IN cord-023095-4dannjjm 977 7 experts expert NNS cord-023095-4dannjjm 977 8 was be VBD cord-023095-4dannjjm 977 9 utilized utilize VBN cord-023095-4dannjjm 977 10 to to TO cord-023095-4dannjjm 977 11 identify identify VB cord-023095-4dannjjm 977 12 and and CC cord-023095-4dannjjm 977 13 to to TO cord-023095-4dannjjm 977 14 weight weight NN cord-023095-4dannjjm 977 15 behaviors behavior NNS cord-023095-4dannjjm 977 16 . . . cord-023095-4dannjjm 978 1 Six six CD cord-023095-4dannjjm 978 2 expert expert NN cord-023095-4dannjjm 978 3 clinicians clinician NNS cord-023095-4dannjjm 978 4 independently independently RB cord-023095-4dannjjm 978 5 expressed express VBD cord-023095-4dannjjm 978 6 opinions opinion NNS cord-023095-4dannjjm 978 7 as as IN cord-023095-4dannjjm 978 8 to to IN cord-023095-4dannjjm 978 9 which which WDT cord-023095-4dannjjm 978 10 of of IN cord-023095-4dannjjm 978 11 46 46 CD cord-023095-4dannjjm 978 12 behaviors behavior NNS cord-023095-4dannjjm 978 13 to to TO cord-023095-4dannjjm 978 14 include include VB cord-023095-4dannjjm 978 15 and and CC cord-023095-4dannjjm 978 16 the the DT cord-023095-4dannjjm 978 17 severity severity NN cord-023095-4dannjjm 978 18 of of IN cord-023095-4dannjjm 978 19 pain pain NN cord-023095-4dannjjm 978 20 they -PRON- PRP cord-023095-4dannjjm 978 21 indicate indicate VBP cord-023095-4dannjjm 978 22 . . . cord-023095-4dannjjm 979 1 Two two CD cord-023095-4dannjjm 979 2 contending contend VBG cord-023095-4dannjjm 979 3 scales scale NNS cord-023095-4dannjjm 979 4 ( ( -LRB- cord-023095-4dannjjm 979 5 Equine equine JJ cord-023095-4dannjjm 979 6 Acute acute JJ cord-023095-4dannjjm 979 7 Abdominal abdominal JJ cord-023095-4dannjjm 979 8 Pain pain NN cord-023095-4dannjjm 979 9 Scales scale NNS cord-023095-4dannjjm 979 10 ( ( -LRB- cord-023095-4dannjjm 979 11 EAAPS EAAPS NNP cord-023095-4dannjjm 979 12 ) ) -RRB- cord-023095-4dannjjm 979 13 1 1 CD cord-023095-4dannjjm 979 14 & & CC cord-023095-4dannjjm 979 15 2 2 CD cord-023095-4dannjjm 979 16 ) ) -RRB- cord-023095-4dannjjm 979 17 were be VBD cord-023095-4dannjjm 979 18 constructed construct VBN cord-023095-4dannjjm 979 19 based base VBN cord-023095-4dannjjm 979 20 on on IN cord-023095-4dannjjm 979 21 both both CC cord-023095-4dannjjm 979 22 the the DT cord-023095-4dannjjm 979 23 empirical empirical JJ cord-023095-4dannjjm 979 24 and and CC cord-023095-4dannjjm 979 25 the the DT cord-023095-4dannjjm 979 26 judgmental judgmental JJ cord-023095-4dannjjm 979 27 approaches approach NNS cord-023095-4dannjjm 979 28 . . . cord-023095-4dannjjm 980 1 Each each DT cord-023095-4dannjjm 980 2 included include VBD cord-023095-4dannjjm 980 3 12 12 CD cord-023095-4dannjjm 980 4 identical identical JJ cord-023095-4dannjjm 980 5 behaviors behavior NNS cord-023095-4dannjjm 980 6 with with IN cord-023095-4dannjjm 980 7 a a DT cord-023095-4dannjjm 980 8 1 1 CD cord-023095-4dannjjm 980 9 - - SYM cord-023095-4dannjjm 980 10 5 5 CD cord-023095-4dannjjm 980 11 point point NN cord-023095-4dannjjm 980 12 score score NN cord-023095-4dannjjm 980 13 range range NN cord-023095-4dannjjm 980 14 ; ; : cord-023095-4dannjjm 980 15 EAAPS-2 eaaps-2 NN cord-023095-4dannjjm 980 16 with with IN cord-023095-4dannjjm 980 17 gradations gradation NNS cord-023095-4dannjjm 980 18 to to IN cord-023095-4dannjjm 980 19 some some DT cord-023095-4dannjjm 980 20 of of IN cord-023095-4dannjjm 980 21 the the DT cord-023095-4dannjjm 980 22 behaviors behavior NNS cord-023095-4dannjjm 980 23 and and CC cord-023095-4dannjjm 980 24 EAAPS-1 eaaps-1 NN cord-023095-4dannjjm 980 25 without without IN cord-023095-4dannjjm 980 26 . . . cord-023095-4dannjjm 981 1 In in IN cord-023095-4dannjjm 981 2 the the DT cord-023095-4dannjjm 981 3 third third JJ cord-023095-4dannjjm 981 4 stage stage NN cord-023095-4dannjjm 981 5 , , , cord-023095-4dannjjm 981 6 blood blood NN cord-023095-4dannjjm 981 7 cortisol cortisol NN cord-023095-4dannjjm 981 8 and and CC cord-023095-4dannjjm 981 9 lactate lactate NN cord-023095-4dannjjm 981 10 levels level NNS cord-023095-4dannjjm 981 11 and and CC cord-023095-4dannjjm 981 12 heart heart NN cord-023095-4dannjjm 981 13 rate rate NN cord-023095-4dannjjm 981 14 were be VBD cord-023095-4dannjjm 981 15 shown show VBN cord-023095-4dannjjm 981 16 to to IN cord-023095-4dannjjm 981 17 only only JJ cord-023095-4dannjjm 981 18 approximate approximate JJ cord-023095-4dannjjm 981 19 pain pain NN cord-023095-4dannjjm 981 20 since since IN cord-023095-4dannjjm 981 21 they -PRON- PRP cord-023095-4dannjjm 981 22 correlate correlate VBP cord-023095-4dannjjm 981 23 poorly poorly RB cord-023095-4dannjjm 981 24 with with IN cord-023095-4dannjjm 981 25 degree degree NN cord-023095-4dannjjm 981 26 of of IN cord-023095-4dannjjm 981 27 pain pain NN cord-023095-4dannjjm 981 28 as as IN cord-023095-4dannjjm 981 29 assessed assess VBN cord-023095-4dannjjm 981 30 by by IN cord-023095-4dannjjm 981 31 visual visual JJ cord-023095-4dannjjm 981 32 analog analog NN cord-023095-4dannjjm 981 33 scale scale NN cord-023095-4dannjjm 981 34 ( ( -LRB- cord-023095-4dannjjm 981 35 VAS VAS NNP cord-023095-4dannjjm 981 36 ) ) -RRB- cord-023095-4dannjjm 981 37 in in IN cord-023095-4dannjjm 981 38 32 32 CD cord-023095-4dannjjm 981 39 horses horse NNS cord-023095-4dannjjm 981 40 with with IN cord-023095-4dannjjm 981 41 colic colic NN cord-023095-4dannjjm 981 42 and and CC cord-023095-4dannjjm 981 43 8 8 CD cord-023095-4dannjjm 981 44 controls control NNS cord-023095-4dannjjm 981 45 ( ( -LRB- cord-023095-4dannjjm 981 46 Spearman Spearman NNP cord-023095-4dannjjm 981 47 rho rho NN cord-023095-4dannjjm 981 48 ; ; : cord-023095-4dannjjm 981 49 lactate lactate NNP cord-023095-4dannjjm 981 50 0.359 0.359 CD cord-023095-4dannjjm 981 51 ; ; : cord-023095-4dannjjm 981 52 cortisol cortisol NN cord-023095-4dannjjm 981 53 0.214 0.214 CD cord-023095-4dannjjm 981 54 ; ; : cord-023095-4dannjjm 981 55 heart heart NN cord-023095-4dannjjm 981 56 rate rate NN cord-023095-4dannjjm 981 57 0.261 0.261 CD cord-023095-4dannjjm 981 58 ) ) -RRB- cord-023095-4dannjjm 981 59 . . . cord-023095-4dannjjm 982 1 Finally finally RB cord-023095-4dannjjm 982 2 , , , cord-023095-4dannjjm 982 3 reliability reliability NN cord-023095-4dannjjm 982 4 and and CC cord-023095-4dannjjm 982 5 validity validity NN cord-023095-4dannjjm 982 6 of of IN cord-023095-4dannjjm 982 7 the the DT cord-023095-4dannjjm 982 8 pain pain NN cord-023095-4dannjjm 982 9 scales scale NNS cord-023095-4dannjjm 982 10 were be VBD cord-023095-4dannjjm 982 11 evaluated evaluate VBN cord-023095-4dannjjm 982 12 including include VBG cord-023095-4dannjjm 982 13 constructs construct NNS cord-023095-4dannjjm 982 14 of of IN cord-023095-4dannjjm 982 15 pain pain NN cord-023095-4dannjjm 982 16 ; ; : cord-023095-4dannjjm 982 17 face face NN cord-023095-4dannjjm 982 18 validity validity NN cord-023095-4dannjjm 982 19 , , , cord-023095-4dannjjm 982 20 convergent convergent JJ cord-023095-4dannjjm 982 21 and and CC cord-023095-4dannjjm 982 22 discriminate discriminate VB cord-023095-4dannjjm 982 23 validity validity NN cord-023095-4dannjjm 982 24 and and CC cord-023095-4dannjjm 982 25 extreme extreme JJ cord-023095-4dannjjm 982 26 groups group NNS cord-023095-4dannjjm 982 27 . . . cord-023095-4dannjjm 983 1 Thirty thirty CD cord-023095-4dannjjm 983 2 of of IN cord-023095-4dannjjm 983 3 40 40 CD cord-023095-4dannjjm 983 4 films film NNS cord-023095-4dannjjm 983 5 of of IN cord-023095-4dannjjm 983 6 horses horse NNS cord-023095-4dannjjm 983 7 with with IN cord-023095-4dannjjm 983 8 colic colic NN cord-023095-4dannjjm 983 9 were be VBD cord-023095-4dannjjm 983 10 randomly randomly RB cord-023095-4dannjjm 983 11 presented present VBN cord-023095-4dannjjm 983 12 to to IN cord-023095-4dannjjm 983 13 44 44 CD cord-023095-4dannjjm 983 14 expert expert JJ cord-023095-4dannjjm 983 15 equine equine JJ cord-023095-4dannjjm 983 16 clinicians clinician NNS cord-023095-4dannjjm 983 17 internationally internationally RB cord-023095-4dannjjm 983 18 who who WP cord-023095-4dannjjm 983 19 were be VBD cord-023095-4dannjjm 983 20 randomly randomly RB cord-023095-4dannjjm 983 21 allocated allocate VBN cord-023095-4dannjjm 983 22 into into IN cord-023095-4dannjjm 983 23 three three CD cord-023095-4dannjjm 983 24 groups group NNS cord-023095-4dannjjm 983 25 to to TO cord-023095-4dannjjm 983 26 score score VB cord-023095-4dannjjm 983 27 pain pain NN cord-023095-4dannjjm 983 28 ; ; : cord-023095-4dannjjm 983 29 one one CD cord-023095-4dannjjm 983 30 group group NN cord-023095-4dannjjm 983 31 by by IN cord-023095-4dannjjm 983 32 both both CC cord-023095-4dannjjm 983 33 VAS VAS NNP cord-023095-4dannjjm 983 34 and and CC cord-023095-4dannjjm 983 35 numerical numerical JJ cord-023095-4dannjjm 983 36 rating rating NN cord-023095-4dannjjm 983 37 scale scale NN cord-023095-4dannjjm 983 38 ( ( -LRB- cord-023095-4dannjjm 983 39 NRS NRS NNP cord-023095-4dannjjm 983 40 ) ) -RRB- cord-023095-4dannjjm 983 41 ) ) -RRB- cord-023095-4dannjjm 983 42 , , , cord-023095-4dannjjm 983 43 and and CC cord-023095-4dannjjm 983 44 two two CD cord-023095-4dannjjm 983 45 groups group NNS cord-023095-4dannjjm 983 46 , , , cord-023095-4dannjjm 983 47 each each DT cord-023095-4dannjjm 983 48 by by IN cord-023095-4dannjjm 983 49 one one CD cord-023095-4dannjjm 983 50 of of IN cord-023095-4dannjjm 983 51 the the DT cord-023095-4dannjjm 983 52 two two CD cord-023095-4dannjjm 983 53 EAAPS EAAPS NNP cord-023095-4dannjjm 983 54 scales scale NNS cord-023095-4dannjjm 983 55 . . . cord-023095-4dannjjm 984 1 Inter inter JJ cord-023095-4dannjjm 984 2 - - JJ cord-023095-4dannjjm 984 3 observer observer JJ cord-023095-4dannjjm 984 4 reliability reliability NN cord-023095-4dannjjm 984 5 of of IN cord-023095-4dannjjm 984 6 both both DT cord-023095-4dannjjm 984 7 EAAPS EAAPS NNP cord-023095-4dannjjm 984 8 scales scale NNS cord-023095-4dannjjm 984 9 was be VBD cord-023095-4dannjjm 984 10 excellent excellent JJ cord-023095-4dannjjm 985 1 ( ( -LRB- cord-023095-4dannjjm 985 2 Intraclass Intraclass NNP cord-023095-4dannjjm 985 3 Correlation Correlation NNP cord-023095-4dannjjm 985 4 0.8 0.8 CD cord-023095-4dannjjm 985 5 ) ) -RRB- cord-023095-4dannjjm 985 6 . . . cord-023095-4dannjjm 986 1 Intra intra JJ cord-023095-4dannjjm 986 2 - - JJ cord-023095-4dannjjm 986 3 observer observer JJ cord-023095-4dannjjm 986 4 reliability reliability NN cord-023095-4dannjjm 986 5 based base VBN cord-023095-4dannjjm 986 6 on on IN cord-023095-4dannjjm 986 7 scores score NNS cord-023095-4dannjjm 986 8 given give VBN cord-023095-4dannjjm 986 9 for for IN cord-023095-4dannjjm 986 10 identical identical JJ cord-023095-4dannjjm 986 11 films film NNS cord-023095-4dannjjm 986 12 demonstrated demonstrate VBN cord-023095-4dannjjm 986 13 ; ; : cord-023095-4dannjjm 986 14 87 87 CD cord-023095-4dannjjm 986 15 % % NN cord-023095-4dannjjm 986 16 and and CC cord-023095-4dannjjm 986 17 56 56 CD cord-023095-4dannjjm 986 18 % % NN cord-023095-4dannjjm 986 19 agreement agreement NN cord-023095-4dannjjm 986 20 , , , cord-023095-4dannjjm 986 21 kappa kappa NNP cord-023095-4dannjjm 986 22 0.9 0.9 CD cord-023095-4dannjjm 986 23 and and CC cord-023095-4dannjjm 986 24 0.35 0.35 CD cord-023095-4dannjjm 986 25 , , , cord-023095-4dannjjm 986 26 and and CC cord-023095-4dannjjm 986 27 Spearman Spearman NNP cord-023095-4dannjjm 986 28 's 's POS cord-023095-4dannjjm 986 29 rho rho NN cord-023095-4dannjjm 986 30 5 5 CD cord-023095-4dannjjm 986 31 0.97 0.97 CD cord-023095-4dannjjm 986 32 and and CC cord-023095-4dannjjm 986 33 0.58 0.58 CD cord-023095-4dannjjm 986 34 for for IN cord-023095-4dannjjm 986 35 EAAPS-1 eaaps-1 NN cord-023095-4dannjjm 986 36 and and CC cord-023095-4dannjjm 986 37 2 2 CD cord-023095-4dannjjm 986 38 , , , cord-023095-4dannjjm 986 39 respectively respectively RB cord-023095-4dannjjm 986 40 . . . cord-023095-4dannjjm 987 1 Both both DT cord-023095-4dannjjm 987 2 scales scale NNS cord-023095-4dannjjm 987 3 varied vary VBN cord-023095-4dannjjm 987 4 by by IN cord-023095-4dannjjm 987 5 1 1 CD cord-023095-4dannjjm 987 6 score score NN cord-023095-4dannjjm 987 7 between between IN cord-023095-4dannjjm 987 8 observations observation NNS cord-023095-4dannjjm 987 9 . . . cord-023095-4dannjjm 988 1 Face face NN cord-023095-4dannjjm 988 2 validity validity NN cord-023095-4dannjjm 988 3 ; ; : cord-023095-4dannjjm 988 4 each each DT cord-023095-4dannjjm 988 5 group group NN cord-023095-4dannjjm 988 6 reported report VBD cord-023095-4dannjjm 988 7 their -PRON- PRP$ cord-023095-4dannjjm 988 8 scale scale NN cord-023095-4dannjjm 988 9 to to TO cord-023095-4dannjjm 988 10 be be VB cord-023095-4dannjjm 988 11 valid valid JJ cord-023095-4dannjjm 988 12 ( ( -LRB- cord-023095-4dannjjm 988 13 67 67 CD cord-023095-4dannjjm 988 14 % % NN cord-023095-4dannjjm 988 15 & & CC cord-023095-4dannjjm 988 16 81 81 CD cord-023095-4dannjjm 988 17 % % NN cord-023095-4dannjjm 988 18 ) ) -RRB- cord-023095-4dannjjm 988 19 . . . cord-023095-4dannjjm 989 1 Convergent convergent JJ cord-023095-4dannjjm 989 2 validity validity NN cord-023095-4dannjjm 989 3 ; ; : cord-023095-4dannjjm 989 4 the the DT cord-023095-4dannjjm 989 5 scales scale NNS cord-023095-4dannjjm 989 6 compared compare VBN cord-023095-4dannjjm 989 7 favorably favorably RB cord-023095-4dannjjm 989 8 with with IN cord-023095-4dannjjm 989 9 VAS VAS NNP cord-023095-4dannjjm 989 10 / / SYM cord-023095-4dannjjm 989 11 NRS NRS NNP cord-023095-4dannjjm 989 12 scores score NNS cord-023095-4dannjjm 990 1 ( ( -LRB- cord-023095-4dannjjm 990 2 Spearman Spearman NNP cord-023095-4dannjjm 990 3 's 's POS cord-023095-4dannjjm 990 4 rho rho NN cord-023095-4dannjjm 990 5 : : : cord-023095-4dannjjm 990 6 0.84 0.84 CD cord-023095-4dannjjm 990 7 - - HYPH cord-023095-4dannjjm 990 8 0.89 0.89 CD cord-023095-4dannjjm 990 9 ) ) -RRB- cord-023095-4dannjjm 990 10 . . . cord-023095-4dannjjm 991 1 Discriminate discriminate VB cord-023095-4dannjjm 991 2 validity validity NN cord-023095-4dannjjm 991 3 ; ; : cord-023095-4dannjjm 991 4 correlation correlation NN cord-023095-4dannjjm 991 5 to to IN cord-023095-4dannjjm 991 6 heart heart NN cord-023095-4dannjjm 991 7 rate rate NN cord-023095-4dannjjm 991 8 , , , cord-023095-4dannjjm 991 9 lactate lactate NN cord-023095-4dannjjm 991 10 and and CC cord-023095-4dannjjm 991 11 cortisol cortisol NN cord-023095-4dannjjm 991 12 levels level NNS cord-023095-4dannjjm 991 13 was be VBD cord-023095-4dannjjm 991 14 predictably predictably RB cord-023095-4dannjjm 991 15 low low JJ cord-023095-4dannjjm 992 1 ( ( -LRB- cord-023095-4dannjjm 992 2 rho rho NNP cord-023095-4dannjjm 992 3 5 5 CD cord-023095-4dannjjm 992 4 0.2 0.2 CD cord-023095-4dannjjm 992 5 - - HYPH cord-023095-4dannjjm 992 6 0.5 0.5 CD cord-023095-4dannjjm 992 7 ) ) -RRB- cord-023095-4dannjjm 992 8 . . . cord-023095-4dannjjm 993 1 Extreme extreme JJ cord-023095-4dannjjm 993 2 group group NN cord-023095-4dannjjm 993 3 validity validity NN cord-023095-4dannjjm 993 4 ; ; : cord-023095-4dannjjm 993 5 colic colic NN cord-023095-4dannjjm 993 6 horses horse NNS cord-023095-4dannjjm 993 7 scored score VBD cord-023095-4dannjjm 993 8 significantly significantly RB cord-023095-4dannjjm 993 9 higher high JJR cord-023095-4dannjjm 993 10 than than IN cord-023095-4dannjjm 993 11 control control NN cord-023095-4dannjjm 993 12 horses horse NNS cord-023095-4dannjjm 993 13 ; ; : cord-023095-4dannjjm 993 14 scores score NNS cord-023095-4dannjjm 993 15 of of IN cord-023095-4dannjjm 993 16 0.6 0.6 CD cord-023095-4dannjjm 993 17 - - SYM cord-023095-4dannjjm 993 18 0.7 0.7 CD cord-023095-4dannjjm 993 19 in in IN cord-023095-4dannjjm 993 20 controls control NNS cord-023095-4dannjjm 993 21 versus versus IN cord-023095-4dannjjm 993 22 2.6 2.6 CD cord-023095-4dannjjm 993 23 - - SYM cord-023095-4dannjjm 993 24 2.7 2.7 CD cord-023095-4dannjjm 993 25 in in IN cord-023095-4dannjjm 993 26 cases case NNS cord-023095-4dannjjm 993 27 . . . cord-023095-4dannjjm 994 1 In in IN cord-023095-4dannjjm 994 2 conclusion conclusion NN cord-023095-4dannjjm 994 3 , , , cord-023095-4dannjjm 994 4 methodology methodology NN cord-023095-4dannjjm 994 5 established establish VBN cord-023095-4dannjjm 994 6 in in IN cord-023095-4dannjjm 994 7 human human JJ cord-023095-4dannjjm 994 8 medicine medicine NN cord-023095-4dannjjm 994 9 but but CC cord-023095-4dannjjm 994 10 novel novel NN cord-023095-4dannjjm 994 11 in in IN cord-023095-4dannjjm 994 12 veterinary veterinary JJ cord-023095-4dannjjm 994 13 medicine medicine NN cord-023095-4dannjjm 994 14 was be VBD cord-023095-4dannjjm 994 15 used use VBN cord-023095-4dannjjm 994 16 to to TO cord-023095-4dannjjm 994 17 construct construct VB cord-023095-4dannjjm 994 18 and and CC cord-023095-4dannjjm 994 19 validate validate VB cord-023095-4dannjjm 994 20 two two CD cord-023095-4dannjjm 994 21 clinically clinically RB cord-023095-4dannjjm 994 22 feasible feasible JJ cord-023095-4dannjjm 994 23 equine equine JJ cord-023095-4dannjjm 994 24 abdominal abdominal JJ cord-023095-4dannjjm 994 25 pain pain NN cord-023095-4dannjjm 994 26 severity severity NN cord-023095-4dannjjm 994 27 scales scale NNS cord-023095-4dannjjm 994 28 that that WDT cord-023095-4dannjjm 994 29 showed show VBD cord-023095-4dannjjm 994 30 excellent excellent JJ cord-023095-4dannjjm 994 31 reliability reliability NN cord-023095-4dannjjm 994 32 and and CC cord-023095-4dannjjm 994 33 validity validity NN cord-023095-4dannjjm 994 34 . . . cord-023095-4dannjjm 995 1 Further further JJ cord-023095-4dannjjm 995 2 refinement refinement NN cord-023095-4dannjjm 995 3 of of IN cord-023095-4dannjjm 995 4 the the DT cord-023095-4dannjjm 995 5 EAAPS EAAPS NNP cord-023095-4dannjjm 995 6 scale scale NN cord-023095-4dannjjm 995 7 is be VBZ cord-023095-4dannjjm 995 8 advised advise VBN cord-023095-4dannjjm 995 9 prior prior RB cord-023095-4dannjjm 995 10 to to IN cord-023095-4dannjjm 995 11 introduction introduction NN cord-023095-4dannjjm 995 12 into into IN cord-023095-4dannjjm 995 13 clinical clinical JJ cord-023095-4dannjjm 995 14 practice practice NN cord-023095-4dannjjm 995 15 . . . cord-023095-4dannjjm 996 1 Aortic aortic JJ cord-023095-4dannjjm 996 2 valve valve NN cord-023095-4dannjjm 996 3 prolapse prolapse NN cord-023095-4dannjjm 996 4 ( ( -LRB- cord-023095-4dannjjm 996 5 AVP AVP NNP cord-023095-4dannjjm 996 6 ) ) -RRB- cord-023095-4dannjjm 996 7 is be VBZ cord-023095-4dannjjm 996 8 a a DT cord-023095-4dannjjm 996 9 common common JJ cord-023095-4dannjjm 996 10 echocardiographic echocardiographic JJ cord-023095-4dannjjm 996 11 finding finding NN cord-023095-4dannjjm 996 12 in in IN cord-023095-4dannjjm 996 13 horses horse NNS cord-023095-4dannjjm 996 14 , , , cord-023095-4dannjjm 996 15 but but CC cord-023095-4dannjjm 996 16 when when WRB cord-023095-4dannjjm 996 17 compared compare VBN cord-023095-4dannjjm 996 18 with with IN cord-023095-4dannjjm 996 19 mitral mitral JJ cord-023095-4dannjjm 996 20 valve valve NN cord-023095-4dannjjm 996 21 prolapse prolapse NN cord-023095-4dannjjm 996 22 in in IN cord-023095-4dannjjm 996 23 dogs dog NNS cord-023095-4dannjjm 996 24 , , , cord-023095-4dannjjm 996 25 little little JJ cord-023095-4dannjjm 996 26 is be VBZ cord-023095-4dannjjm 996 27 known know VBN cord-023095-4dannjjm 996 28 about about IN cord-023095-4dannjjm 996 29 the the DT cord-023095-4dannjjm 996 30 natural natural JJ cord-023095-4dannjjm 996 31 progression progression NN cord-023095-4dannjjm 996 32 of of IN cord-023095-4dannjjm 996 33 this this DT cord-023095-4dannjjm 996 34 condition condition NN cord-023095-4dannjjm 996 35 . . . cord-023095-4dannjjm 997 1 Previously previously RB cord-023095-4dannjjm 997 2 published publish VBN cord-023095-4dannjjm 997 3 data datum NNS cord-023095-4dannjjm 997 4 has have VBZ cord-023095-4dannjjm 997 5 shown show VBN cord-023095-4dannjjm 997 6 that that IN cord-023095-4dannjjm 997 7 echocardiographic echocardiographic JJ cord-023095-4dannjjm 997 8 identification identification NN cord-023095-4dannjjm 997 9 of of IN cord-023095-4dannjjm 997 10 AVP AVP NNP cord-023095-4dannjjm 997 11 in in IN cord-023095-4dannjjm 997 12 horses horse NNS cord-023095-4dannjjm 997 13 is be VBZ cord-023095-4dannjjm 997 14 reliable reliable JJ cord-023095-4dannjjm 997 15 , , , cord-023095-4dannjjm 997 16 diagnostic diagnostic JJ cord-023095-4dannjjm 997 17 criteria criterion NNS cord-023095-4dannjjm 997 18 have have VBP cord-023095-4dannjjm 997 19 been be VBN cord-023095-4dannjjm 997 20 established establish VBN cord-023095-4dannjjm 997 21 and and CC cord-023095-4dannjjm 997 22 that that IN cord-023095-4dannjjm 997 23 development development NN cord-023095-4dannjjm 997 24 occurs occur VBZ cord-023095-4dannjjm 997 25 with with IN cord-023095-4dannjjm 997 26 training training NN cord-023095-4dannjjm 997 27 . . . cord-023095-4dannjjm 998 1 The the DT cord-023095-4dannjjm 998 2 aims aim NNS cord-023095-4dannjjm 998 3 of of IN cord-023095-4dannjjm 998 4 this this DT cord-023095-4dannjjm 998 5 study study NN cord-023095-4dannjjm 998 6 were be VBD cord-023095-4dannjjm 998 7 to to TO cord-023095-4dannjjm 998 8 evaluate evaluate VB cord-023095-4dannjjm 998 9 the the DT cord-023095-4dannjjm 998 10 different different JJ cord-023095-4dannjjm 998 11 RNA RNA NNP cord-023095-4dannjjm 998 12 and and CC cord-023095-4dannjjm 998 13 protein protein NN cord-023095-4dannjjm 998 14 expressions expression NNS cord-023095-4dannjjm 998 15 of of IN cord-023095-4dannjjm 998 16 smooth smooth JJ cord-023095-4dannjjm 998 17 muscle muscle NN cord-023095-4dannjjm 998 18 actin actin NN cord-023095-4dannjjm 998 19 ( ( -LRB- cord-023095-4dannjjm 998 20 SMA SMA NNP cord-023095-4dannjjm 998 21 ) ) -RRB- cord-023095-4dannjjm 998 22 , , , cord-023095-4dannjjm 998 23 transforming transform VBG cord-023095-4dannjjm 998 24 growth growth NN cord-023095-4dannjjm 998 25 factor factor NN cord-023095-4dannjjm 998 26 - - HYPH cord-023095-4dannjjm 998 27 b b NN cord-023095-4dannjjm 998 28 1 1 CD cord-023095-4dannjjm 998 29 ( ( -LRB- cord-023095-4dannjjm 998 30 TGF TGF NNP cord-023095-4dannjjm 998 31 ) ) -RRB- cord-023095-4dannjjm 998 32 , , , cord-023095-4dannjjm 998 33 nitric nitric JJ cord-023095-4dannjjm 998 34 oxide oxide NN cord-023095-4dannjjm 998 35 synthase synthase NN cord-023095-4dannjjm 998 36 ( ( -LRB- cord-023095-4dannjjm 998 37 NOS NOS NNP cord-023095-4dannjjm 998 38 ) ) -RRB- cord-023095-4dannjjm 998 39 and and CC cord-023095-4dannjjm 998 40 the the DT cord-023095-4dannjjm 998 41 concentrations concentration NNS cord-023095-4dannjjm 998 42 of of IN cord-023095-4dannjjm 998 43 elastin elastin NN cord-023095-4dannjjm 998 44 and and CC cord-023095-4dannjjm 998 45 collagen collagen NN cord-023095-4dannjjm 998 46 in in IN cord-023095-4dannjjm 998 47 normal normal JJ cord-023095-4dannjjm 998 48 , , , cord-023095-4dannjjm 998 49 prolapsing prolapse VBG cord-023095-4dannjjm 998 50 and and CC cord-023095-4dannjjm 998 51 diseased diseased JJ cord-023095-4dannjjm 998 52 cusps cusp NNS cord-023095-4dannjjm 998 53 to to TO cord-023095-4dannjjm 998 54 evaluate evaluate VB cord-023095-4dannjjm 998 55 what what WP cord-023095-4dannjjm 998 56 structural structural JJ cord-023095-4dannjjm 998 57 changes change NNS cord-023095-4dannjjm 998 58 may may MD cord-023095-4dannjjm 998 59 predispose predispose VB cord-023095-4dannjjm 998 60 them -PRON- PRP cord-023095-4dannjjm 998 61 to to TO cord-023095-4dannjjm 998 62 prolapse prolapse VB cord-023095-4dannjjm 998 63 . . . cord-023095-4dannjjm 999 1 Valve valve NN cord-023095-4dannjjm 999 2 cusps cusp NNS cord-023095-4dannjjm 999 3 were be VBD cord-023095-4dannjjm 999 4 harvested harvest VBN cord-023095-4dannjjm 999 5 and and CC cord-023095-4dannjjm 999 6 processed process VBN cord-023095-4dannjjm 999 7 from from IN cord-023095-4dannjjm 999 8 a a DT cord-023095-4dannjjm 999 9 group group NN cord-023095-4dannjjm 999 10 of of IN cord-023095-4dannjjm 999 11 176 176 CD cord-023095-4dannjjm 999 12 horses horse NNS cord-023095-4dannjjm 999 13 at at IN cord-023095-4dannjjm 999 14 a a DT cord-023095-4dannjjm 999 15 commercial commercial JJ cord-023095-4dannjjm 999 16 abattoir abattoir NN cord-023095-4dannjjm 999 17 following follow VBG cord-023095-4dannjjm 999 18 disease disease NN cord-023095-4dannjjm 999 19 classification classification NN cord-023095-4dannjjm 999 20 using use VBG cord-023095-4dannjjm 999 21 echocardiography echocardiography NN cord-023095-4dannjjm 999 22 . . . cord-023095-4dannjjm 1000 1 Horses horse NNS cord-023095-4dannjjm 1000 2 were be VBD cord-023095-4dannjjm 1000 3 aged aged JJ cord-023095-4dannjjm 1000 4 13.7 13.7 CD cord-023095-4dannjjm 1000 5 AE AE NNP cord-023095-4dannjjm 1000 6 6.7years 6.7year NNS cord-023095-4dannjjm 1000 7 , , , cord-023095-4dannjjm 1000 8 weighing weigh VBG cord-023095-4dannjjm 1000 9 518 518 CD cord-023095-4dannjjm 1000 10 AE AE NNP cord-023095-4dannjjm 1000 11 51 51 CD cord-023095-4dannjjm 1000 12 Kg kg CD cord-023095-4dannjjm 1000 13 and and CC cord-023095-4dannjjm 1000 14 with with IN cord-023095-4dannjjm 1000 15 a a DT cord-023095-4dannjjm 1000 16 median median JJ cord-023095-4dannjjm 1000 17 body body NN cord-023095-4dannjjm 1000 18 condition condition NN cord-023095-4dannjjm 1000 19 score score NN cord-023095-4dannjjm 1000 20 of of IN cord-023095-4dannjjm 1000 21 4/9 4/9 CD cord-023095-4dannjjm 1000 22 . . . cord-023095-4dannjjm 1001 1 Cusps Cusps NNP cord-023095-4dannjjm 1001 2 were be VBD cord-023095-4dannjjm 1001 3 collected collect VBN cord-023095-4dannjjm 1001 4 in in IN cord-023095-4dannjjm 1001 5 RNAlater RNAlater NNP cord-023095-4dannjjm 1001 6 s s NNP cord-023095-4dannjjm 1001 7 and and CC cord-023095-4dannjjm 1001 8 stored store VBN cord-023095-4dannjjm 1001 9 at at IN cord-023095-4dannjjm 1001 10 À801C À801C NNPS cord-023095-4dannjjm 1001 11 prior prior RB cord-023095-4dannjjm 1001 12 to to IN cord-023095-4dannjjm 1001 13 processing processing NN cord-023095-4dannjjm 1001 14 . . . cord-023095-4dannjjm 1002 1 cDNA cDNA NNP cord-023095-4dannjjm 1002 2 was be VBD cord-023095-4dannjjm 1002 3 produced produce VBN cord-023095-4dannjjm 1002 4 from from IN cord-023095-4dannjjm 1002 5 half half PDT cord-023095-4dannjjm 1002 6 a a DT cord-023095-4dannjjm 1002 7 valve valve NN cord-023095-4dannjjm 1002 8 using use VBG cord-023095-4dannjjm 1002 9 a a DT cord-023095-4dannjjm 1002 10 standard standard JJ cord-023095-4dannjjm 1002 11 protocoland protocoland NN cord-023095-4dannjjm 1002 12 qRT qRT NNP cord-023095-4dannjjm 1002 13 - - HYPH cord-023095-4dannjjm 1002 14 PCR PCR NNP cord-023095-4dannjjm 1002 15 performed perform VBN cord-023095-4dannjjm 1002 16 to to TO cord-023095-4dannjjm 1002 17 assess assess VB cord-023095-4dannjjm 1002 18 relative relative JJ cord-023095-4dannjjm 1002 19 RNA RNA NNP cord-023095-4dannjjm 1002 20 expression expression NN cord-023095-4dannjjm 1002 21 of of IN cord-023095-4dannjjm 1002 22 SMA SMA NNP cord-023095-4dannjjm 1002 23 , , , cord-023095-4dannjjm 1002 24 TGFb tgfb JJ cord-023095-4dannjjm 1002 25 1 1 CD cord-023095-4dannjjm 1002 26 , , , cord-023095-4dannjjm 1002 27 endothelial endothelial JJ cord-023095-4dannjjm 1002 28 ( ( -LRB- cord-023095-4dannjjm 1002 29 eNOS enos JJ cord-023095-4dannjjm 1002 30 ) ) -RRB- cord-023095-4dannjjm 1002 31 and and CC cord-023095-4dannjjm 1002 32 inducible inducible JJ cord-023095-4dannjjm 1002 33 NOS NOS NNP cord-023095-4dannjjm 1002 34 ( ( -LRB- cord-023095-4dannjjm 1002 35 iNOS inos NN cord-023095-4dannjjm 1002 36 ) ) -RRB- cord-023095-4dannjjm 1002 37 and and CC cord-023095-4dannjjm 1002 38 compared compare VBN cord-023095-4dannjjm 1002 39 with with IN cord-023095-4dannjjm 1002 40 the the DT cord-023095-4dannjjm 1002 41 housekeeping housekeeping NN cord-023095-4dannjjm 1002 42 gene gene NN cord-023095-4dannjjm 1002 43 18S. 18s. CD cord-023095-4dannjjm 1002 44 A a DT cord-023095-4dannjjm 1002 45 quarter quarter NN cord-023095-4dannjjm 1002 46 of of IN cord-023095-4dannjjm 1002 47 cusp cusp NN cord-023095-4dannjjm 1002 48 was be VBD cord-023095-4dannjjm 1002 49 processed process VBN cord-023095-4dannjjm 1002 50 using use VBG cord-023095-4dannjjm 1002 51 an an DT cord-023095-4dannjjm 1002 52 adapted adapt VBN cord-023095-4dannjjm 1002 53 commercial commercial JJ cord-023095-4dannjjm 1002 54 protocol protocol NN cord-023095-4dannjjm 1002 55 to to TO cord-023095-4dannjjm 1002 56 evaluate evaluate VB cord-023095-4dannjjm 1002 57 protein protein NN cord-023095-4dannjjm 1002 58 expression expression NN cord-023095-4dannjjm 1002 59 of of IN cord-023095-4dannjjm 1002 60 SMA SMA NNP cord-023095-4dannjjm 1002 61 , , , cord-023095-4dannjjm 1002 62 TGF TGF NNP cord-023095-4dannjjm 1002 63 b b NNP cord-023095-4dannjjm 1002 64 1 1 CD cord-023095-4dannjjm 1002 65 , , , cord-023095-4dannjjm 1002 66 eNOS enos JJ cord-023095-4dannjjm 1002 67 and and CC cord-023095-4dannjjm 1002 68 compared compare VBN cord-023095-4dannjjm 1002 69 to to IN cord-023095-4dannjjm 1002 70 vimentin vimentin NNS cord-023095-4dannjjm 1002 71 . . . cord-023095-4dannjjm 1003 1 Specific specific JJ cord-023095-4dannjjm 1003 2 antibody antibody NN cord-023095-4dannjjm 1003 3 binding binding NN cord-023095-4dannjjm 1003 4 was be VBD cord-023095-4dannjjm 1003 5 assessed assess VBN cord-023095-4dannjjm 1003 6 with with IN cord-023095-4dannjjm 1003 7 western western JJ cord-023095-4dannjjm 1003 8 blotting blotting NN cord-023095-4dannjjm 1003 9 and and CC cord-023095-4dannjjm 1003 10 protein protein NN cord-023095-4dannjjm 1003 11 expression expression NN cord-023095-4dannjjm 1003 12 evaluated evaluate VBD cord-023095-4dannjjm 1003 13 using use VBG cord-023095-4dannjjm 1003 14 dot dot NN cord-023095-4dannjjm 1003 15 blots blot NNS cord-023095-4dannjjm 1003 16 . . . cord-023095-4dannjjm 1004 1 The the DT cord-023095-4dannjjm 1004 2 remaining remain VBG cord-023095-4dannjjm 1004 3 quarter quarter NN cord-023095-4dannjjm 1004 4 cusp cusp NN cord-023095-4dannjjm 1004 5 was be VBD cord-023095-4dannjjm 1004 6 used use VBN cord-023095-4dannjjm 1004 7 to to TO cord-023095-4dannjjm 1004 8 measure measure VB cord-023095-4dannjjm 1004 9 soluble soluble JJ cord-023095-4dannjjm 1004 10 collagen collagen NN cord-023095-4dannjjm 1004 11 and and CC cord-023095-4dannjjm 1004 12 elastin elastin NN cord-023095-4dannjjm 1004 13 concentrations concentration NNS cord-023095-4dannjjm 1004 14 using use VBG cord-023095-4dannjjm 1004 15 commercial commercial JJ cord-023095-4dannjjm 1004 16 assays assay NNS cord-023095-4dannjjm 1004 17 3 3 CD cord-023095-4dannjjm 1004 18 . . . cord-023095-4dannjjm 1005 1 Statistical statistical JJ cord-023095-4dannjjm 1005 2 analyses analysis NNS cord-023095-4dannjjm 1005 3 included include VBD cord-023095-4dannjjm 1005 4 one one CD cord-023095-4dannjjm 1005 5 way way NN cord-023095-4dannjjm 1005 6 ANOVA ANOVA NNP cord-023095-4dannjjm 1005 7 with with IN cord-023095-4dannjjm 1005 8 post post JJ cord-023095-4dannjjm 1005 9 - - JJ cord-023095-4dannjjm 1005 10 hoc hoc JJ cord-023095-4dannjjm 1005 11 Bonferoni Bonferoni NNP cord-023095-4dannjjm 1005 12 , , , cord-023095-4dannjjm 1005 13 paired pair VBN cord-023095-4dannjjm 1005 14 Student Student NNP cord-023095-4dannjjm 1005 15 's 's POS cord-023095-4dannjjm 1005 16 T t NN cord-023095-4dannjjm 1005 17 - - HYPH cord-023095-4dannjjm 1005 18 test test NN cord-023095-4dannjjm 1005 19 , , , cord-023095-4dannjjm 1005 20 linear linear JJ cord-023095-4dannjjm 1005 21 and and CC cord-023095-4dannjjm 1005 22 logistic logistic JJ cord-023095-4dannjjm 1005 23 regression regression NN cord-023095-4dannjjm 1005 24 . . . cord-023095-4dannjjm 1006 1 There there EX cord-023095-4dannjjm 1006 2 was be VBD cord-023095-4dannjjm 1006 3 no no DT cord-023095-4dannjjm 1006 4 effect effect NN cord-023095-4dannjjm 1006 5 of of IN cord-023095-4dannjjm 1006 6 gender gender NN cord-023095-4dannjjm 1006 7 or or CC cord-023095-4dannjjm 1006 8 age age NN cord-023095-4dannjjm 1006 9 on on IN cord-023095-4dannjjm 1006 10 any any DT cord-023095-4dannjjm 1006 11 of of IN cord-023095-4dannjjm 1006 12 the the DT cord-023095-4dannjjm 1006 13 measurements measurement NNS cord-023095-4dannjjm 1006 14 . . . cord-023095-4dannjjm 1007 1 Valves valve NNS cord-023095-4dannjjm 1007 2 from from IN cord-023095-4dannjjm 1007 3 animals animal NNS cord-023095-4dannjjm 1007 4 with with IN cord-023095-4dannjjm 1007 5 AVP AVP NNP cord-023095-4dannjjm 1007 6 had have VBD cord-023095-4dannjjm 1007 7 lower low JJR cord-023095-4dannjjm 1007 8 expression expression NN cord-023095-4dannjjm 1007 9 of of IN cord-023095-4dannjjm 1007 10 SMA SMA NNP cord-023095-4dannjjm 1007 11 and and CC cord-023095-4dannjjm 1007 12 Elastin Elastin NNP cord-023095-4dannjjm 1007 13 compared compare VBN cord-023095-4dannjjm 1007 14 to to IN cord-023095-4dannjjm 1007 15 normal normal JJ cord-023095-4dannjjm 1007 16 and and CC cord-023095-4dannjjm 1007 17 diseased diseased JJ cord-023095-4dannjjm 1007 18 valves valve NNS cord-023095-4dannjjm 1007 19 , , , cord-023095-4dannjjm 1007 20 increased increase VBN cord-023095-4dannjjm 1007 21 expression expression NN cord-023095-4dannjjm 1007 22 of of IN cord-023095-4dannjjm 1007 23 TGFb tgfb JJ cord-023095-4dannjjm 1007 24 1 1 CD cord-023095-4dannjjm 1007 25 and and CC cord-023095-4dannjjm 1007 26 eNOS enos JJ cord-023095-4dannjjm 1007 27 , , , cord-023095-4dannjjm 1007 28 whereas whereas IN cord-023095-4dannjjm 1007 29 iNOS inos JJ cord-023095-4dannjjm 1007 30 expression expression NN cord-023095-4dannjjm 1007 31 was be VBD cord-023095-4dannjjm 1007 32 greater great JJR cord-023095-4dannjjm 1007 33 than than IN cord-023095-4dannjjm 1007 34 normal normal JJ cord-023095-4dannjjm 1007 35 valves valve NNS cord-023095-4dannjjm 1007 36 ( ( -LRB- cord-023095-4dannjjm 1007 37 Table table NN cord-023095-4dannjjm 1007 38 1 1 CD cord-023095-4dannjjm 1007 39 ) ) -RRB- cord-023095-4dannjjm 1007 40 . . . cord-023095-4dannjjm 1008 1 Collagen collagen NN cord-023095-4dannjjm 1008 2 content content NN cord-023095-4dannjjm 1008 3 of of IN cord-023095-4dannjjm 1008 4 valves valve NNS cord-023095-4dannjjm 1008 5 from from IN cord-023095-4dannjjm 1008 6 horses horse NNS cord-023095-4dannjjm 1008 7 with with IN cord-023095-4dannjjm 1008 8 AVP AVP NNP cord-023095-4dannjjm 1008 9 was be VBD cord-023095-4dannjjm 1008 10 increased increase VBN cord-023095-4dannjjm 1008 11 compared compare VBN cord-023095-4dannjjm 1008 12 to to IN cord-023095-4dannjjm 1008 13 normal normal JJ cord-023095-4dannjjm 1008 14 but but CC cord-023095-4dannjjm 1008 15 lower low JJR cord-023095-4dannjjm 1008 16 than than IN cord-023095-4dannjjm 1008 17 horses horse NNS cord-023095-4dannjjm 1008 18 with with IN cord-023095-4dannjjm 1008 19 valve valve NN cord-023095-4dannjjm 1008 20 disease disease NN cord-023095-4dannjjm 1008 21 . . . cord-023095-4dannjjm 1009 1 Prolapsing prolapse VBG cord-023095-4dannjjm 1009 2 cusps cusp NNS cord-023095-4dannjjm 1009 3 appear appear VBP cord-023095-4dannjjm 1009 4 to to TO cord-023095-4dannjjm 1009 5 be be VB cord-023095-4dannjjm 1009 6 a a DT cord-023095-4dannjjm 1009 7 different different JJ cord-023095-4dannjjm 1009 8 phenotype phenotype NN cord-023095-4dannjjm 1009 9 from from IN cord-023095-4dannjjm 1009 10 diseased diseased JJ cord-023095-4dannjjm 1009 11 cusps cusp NNS cord-023095-4dannjjm 1009 12 . . . cord-023095-4dannjjm 1010 1 Further further JJ cord-023095-4dannjjm 1010 2 studies study NNS cord-023095-4dannjjm 1010 3 will will MD cord-023095-4dannjjm 1010 4 help help VB cord-023095-4dannjjm 1010 5 to to TO cord-023095-4dannjjm 1010 6 elucidate elucidate VB cord-023095-4dannjjm 1010 7 the the DT cord-023095-4dannjjm 1010 8 significance significance NN cord-023095-4dannjjm 1010 9 of of IN cord-023095-4dannjjm 1010 10 these these DT cord-023095-4dannjjm 1010 11 findings finding NNS cord-023095-4dannjjm 1010 12 in in IN cord-023095-4dannjjm 1010 13 vivo vivo NN cord-023095-4dannjjm 1010 14 . . . cord-023095-4dannjjm 1011 1 A a DT cord-023095-4dannjjm 1011 2 clear clear JJ cord-023095-4dannjjm 1011 3 association association NN cord-023095-4dannjjm 1011 4 between between IN cord-023095-4dannjjm 1011 5 heart heart NN cord-023095-4dannjjm 1011 6 rate rate NN cord-023095-4dannjjm 1011 7 ( ( -LRB- cord-023095-4dannjjm 1011 8 HR HR NNP cord-023095-4dannjjm 1011 9 ) ) -RRB- cord-023095-4dannjjm 1011 10 and and CC cord-023095-4dannjjm 1011 11 body body NN cord-023095-4dannjjm 1011 12 mass mass NN cord-023095-4dannjjm 1011 13 has have VBZ cord-023095-4dannjjm 1011 14 been be VBN cord-023095-4dannjjm 1011 15 observed observe VBN cord-023095-4dannjjm 1011 16 across across IN cord-023095-4dannjjm 1011 17 a a DT cord-023095-4dannjjm 1011 18 wide wide JJ cord-023095-4dannjjm 1011 19 range range NN cord-023095-4dannjjm 1011 20 of of IN cord-023095-4dannjjm 1011 21 mammalian mammalian JJ cord-023095-4dannjjm 1011 22 species specie NNS cord-023095-4dannjjm 1011 23 . . . cord-023095-4dannjjm 1012 1 Furthermore furthermore RB cord-023095-4dannjjm 1012 2 , , , cord-023095-4dannjjm 1012 3 it -PRON- PRP cord-023095-4dannjjm 1012 4 is be VBZ cord-023095-4dannjjm 1012 5 well well RB cord-023095-4dannjjm 1012 6 known know VBN cord-023095-4dannjjm 1012 7 that that IN cord-023095-4dannjjm 1012 8 electrocardiographic electrocardiographic NNP cord-023095-4dannjjm 1012 9 ( ( -LRB- cord-023095-4dannjjm 1012 10 ECG ECG NNP cord-023095-4dannjjm 1012 11 ) ) -RRB- cord-023095-4dannjjm 1012 12 time time NN cord-023095-4dannjjm 1012 13 intervals interval NNS cord-023095-4dannjjm 1012 14 vary vary VBP cord-023095-4dannjjm 1012 15 with with IN cord-023095-4dannjjm 1012 16 heart heart NN cord-023095-4dannjjm 1012 17 rate rate NN cord-023095-4dannjjm 1012 18 and and CC cord-023095-4dannjjm 1012 19 body body NN cord-023095-4dannjjm 1012 20 mass mass NN cord-023095-4dannjjm 1012 21 . . . cord-023095-4dannjjm 1013 1 Within within IN cord-023095-4dannjjm 1013 2 the the DT cord-023095-4dannjjm 1013 3 equine equine JJ cord-023095-4dannjjm 1013 4 species specie NNS cord-023095-4dannjjm 1013 5 , , , cord-023095-4dannjjm 1013 6 small small JJ cord-023095-4dannjjm 1013 7 breeds breed NNS cord-023095-4dannjjm 1013 8 are be VBP cord-023095-4dannjjm 1013 9 generally generally RB cord-023095-4dannjjm 1013 10 thought think VBN cord-023095-4dannjjm 1013 11 to to TO cord-023095-4dannjjm 1013 12 have have VB cord-023095-4dannjjm 1013 13 higher high JJR cord-023095-4dannjjm 1013 14 heart heart NN cord-023095-4dannjjm 1013 15 rates rate NNS cord-023095-4dannjjm 1013 16 than than IN cord-023095-4dannjjm 1013 17 large large JJ cord-023095-4dannjjm 1013 18 breeds breed NNS cord-023095-4dannjjm 1013 19 . . . cord-023095-4dannjjm 1014 1 However however RB cord-023095-4dannjjm 1014 2 , , , cord-023095-4dannjjm 1014 3 despite despite IN cord-023095-4dannjjm 1014 4 the the DT cord-023095-4dannjjm 1014 5 large large JJ cord-023095-4dannjjm 1014 6 differences difference NNS cord-023095-4dannjjm 1014 7 in in IN cord-023095-4dannjjm 1014 8 size size NN cord-023095-4dannjjm 1014 9 among among IN cord-023095-4dannjjm 1014 10 different different JJ cord-023095-4dannjjm 1014 11 equine equine NN cord-023095-4dannjjm 1014 12 breeds breed NNS cord-023095-4dannjjm 1014 13 , , , cord-023095-4dannjjm 1014 14 there there EX cord-023095-4dannjjm 1014 15 is be VBZ cord-023095-4dannjjm 1014 16 little little JJ cord-023095-4dannjjm 1014 17 information information NN cord-023095-4dannjjm 1014 18 about about IN cord-023095-4dannjjm 1014 19 normal normal JJ cord-023095-4dannjjm 1014 20 heart heart NN cord-023095-4dannjjm 1014 21 rates rate NNS cord-023095-4dannjjm 1014 22 and and CC cord-023095-4dannjjm 1014 23 normal normal JJ cord-023095-4dannjjm 1014 24 ECG ECG NNP cord-023095-4dannjjm 1014 25 time time NN cord-023095-4dannjjm 1014 26 intervals interval NNS cord-023095-4dannjjm 1014 27 in in IN cord-023095-4dannjjm 1014 28 horses horse NNS cord-023095-4dannjjm 1014 29 and and CC cord-023095-4dannjjm 1014 30 ponies pony NNS cord-023095-4dannjjm 1014 31 of of IN cord-023095-4dannjjm 1014 32 different different JJ cord-023095-4dannjjm 1014 33 body body NN cord-023095-4dannjjm 1014 34 size size NN cord-023095-4dannjjm 1014 35 . . . cord-023095-4dannjjm 1015 1 Similarly similarly RB cord-023095-4dannjjm 1015 2 , , , cord-023095-4dannjjm 1015 3 the the DT cord-023095-4dannjjm 1015 4 relationship relationship NN cord-023095-4dannjjm 1015 5 between between IN cord-023095-4dannjjm 1015 6 HR hr NN cord-023095-4dannjjm 1015 7 and and CC cord-023095-4dannjjm 1015 8 body body NN cord-023095-4dannjjm 1015 9 mass mass NN cord-023095-4dannjjm 1015 10 in in IN cord-023095-4dannjjm 1015 11 dogs dog NNS cord-023095-4dannjjm 1015 12 of of IN cord-023095-4dannjjm 1015 13 various various JJ cord-023095-4dannjjm 1015 14 breeds breed NNS cord-023095-4dannjjm 1015 15 and and CC cord-023095-4dannjjm 1015 16 sizes size NNS cord-023095-4dannjjm 1015 17 is be VBZ cord-023095-4dannjjm 1015 18 still still RB cord-023095-4dannjjm 1015 19 under under IN cord-023095-4dannjjm 1015 20 debate debate NN cord-023095-4dannjjm 1015 21 . . . cord-023095-4dannjjm 1016 1 The the DT cord-023095-4dannjjm 1016 2 goal goal NN cord-023095-4dannjjm 1016 3 of of IN cord-023095-4dannjjm 1016 4 this this DT cord-023095-4dannjjm 1016 5 study study NN cord-023095-4dannjjm 1016 6 was be VBD cord-023095-4dannjjm 1016 7 to to TO cord-023095-4dannjjm 1016 8 investigate investigate VB cord-023095-4dannjjm 1016 9 the the DT cord-023095-4dannjjm 1016 10 relationship relationship NN cord-023095-4dannjjm 1016 11 between between IN cord-023095-4dannjjm 1016 12 heart heart NN cord-023095-4dannjjm 1016 13 rate rate NN cord-023095-4dannjjm 1016 14 and and CC cord-023095-4dannjjm 1016 15 ECG ECG NNP cord-023095-4dannjjm 1016 16 time time NN cord-023095-4dannjjm 1016 17 intervals interval NNS cord-023095-4dannjjm 1016 18 to to IN cord-023095-4dannjjm 1016 19 body body NN cord-023095-4dannjjm 1016 20 mass mass NN cord-023095-4dannjjm 1016 21 in in IN cord-023095-4dannjjm 1016 22 apparently apparently RB cord-023095-4dannjjm 1016 23 healthy healthy JJ cord-023095-4dannjjm 1016 24 horses horse NNS cord-023095-4dannjjm 1016 25 and and CC cord-023095-4dannjjm 1016 26 ponies pony NNS cord-023095-4dannjjm 1016 27 and and CC cord-023095-4dannjjm 1016 28 to to TO cord-023095-4dannjjm 1016 29 calculate calculate VB cord-023095-4dannjjm 1016 30 normal normal JJ cord-023095-4dannjjm 1016 31 ranges range NNS cord-023095-4dannjjm 1016 32 for for IN cord-023095-4dannjjm 1016 33 different different JJ cord-023095-4dannjjm 1016 34 weight weight NN cord-023095-4dannjjm 1016 35 groups group NNS cord-023095-4dannjjm 1016 36 . . . cord-023095-4dannjjm 1017 1 250 250 CD cord-023095-4dannjjm 1017 2 adult adult NN cord-023095-4dannjjm 1017 3 horses horse NNS cord-023095-4dannjjm 1017 4 and and CC cord-023095-4dannjjm 1017 5 ponies pony NNS cord-023095-4dannjjm 1017 6 at at IN cord-023095-4dannjjm 1017 7 an an DT cord-023095-4dannjjm 1017 8 age age NN cord-023095-4dannjjm 1017 9 of of IN cord-023095-4dannjjm 1017 10 5.5 5.5 CD cord-023095-4dannjjm 1017 11 ( ( -LRB- cord-023095-4dannjjm 1017 12 1 1 CD cord-023095-4dannjjm 1017 13 - - SYM cord-023095-4dannjjm 1017 14 30 30 CD cord-023095-4dannjjm 1017 15 ) ) -RRB- cord-023095-4dannjjm 1017 16 y y NN cord-023095-4dannjjm 1017 17 [ [ -LRB- cord-023095-4dannjjm 1017 18 median median NN cord-023095-4dannjjm 1017 19 ( ( -LRB- cord-023095-4dannjjm 1017 20 range range NN cord-023095-4dannjjm 1017 21 ) ) -RRB- cord-023095-4dannjjm 1017 22 ] ] -RRB- cord-023095-4dannjjm 1017 23 and and CC cord-023095-4dannjjm 1017 24 a a DT cord-023095-4dannjjm 1017 25 body body NN cord-023095-4dannjjm 1017 26 weight weight NN cord-023095-4dannjjm 1017 27 of of IN cord-023095-4dannjjm 1017 28 479 479 CD cord-023095-4dannjjm 1017 29 ( ( -LRB- cord-023095-4dannjjm 1017 30 46 46 CD cord-023095-4dannjjm 1017 31 - - SYM cord-023095-4dannjjm 1017 32 1120 1120 CD cord-023095-4dannjjm 1017 33 ) ) -RRB- cord-023095-4dannjjm 1017 34 kg kg NNS cord-023095-4dannjjm 1017 35 were be VBD cord-023095-4dannjjm 1017 36 included include VBN cord-023095-4dannjjm 1017 37 in in IN cord-023095-4dannjjm 1017 38 the the DT cord-023095-4dannjjm 1017 39 study study NN cord-023095-4dannjjm 1017 40 . . . cord-023095-4dannjjm 1018 1 All all DT cord-023095-4dannjjm 1018 2 animals animal NNS cord-023095-4dannjjm 1018 3 were be VBD cord-023095-4dannjjm 1018 4 considered consider VBN cord-023095-4dannjjm 1018 5 clinically clinically RB cord-023095-4dannjjm 1018 6 healthy healthy JJ cord-023095-4dannjjm 1018 7 based base VBN cord-023095-4dannjjm 1018 8 on on IN cord-023095-4dannjjm 1018 9 history history NN cord-023095-4dannjjm 1018 10 and and CC cord-023095-4dannjjm 1018 11 physical physical JJ cord-023095-4dannjjm 1018 12 examination examination NN cord-023095-4dannjjm 1018 13 . . . cord-023095-4dannjjm 1019 1 A a DT cord-023095-4dannjjm 1019 2 standard standard JJ cord-023095-4dannjjm 1019 3 base base NN cord-023095-4dannjjm 1019 4 - - HYPH cord-023095-4dannjjm 1019 5 apex apex NN cord-023095-4dannjjm 1019 6 ECG ECG NNP cord-023095-4dannjjm 1019 7 was be VBD cord-023095-4dannjjm 1019 8 recorded record VBN cord-023095-4dannjjm 1019 9 at at IN cord-023095-4dannjjm 1019 10 a a DT cord-023095-4dannjjm 1019 11 speed speed NN cord-023095-4dannjjm 1019 12 of of IN cord-023095-4dannjjm 1019 13 25 25 CD cord-023095-4dannjjm 1019 14 ( ( -LRB- cord-023095-4dannjjm 1019 15 n n NN cord-023095-4dannjjm 1019 16 5 5 CD cord-023095-4dannjjm 1019 17 4 4 CD cord-023095-4dannjjm 1019 18 ) ) -RRB- cord-023095-4dannjjm 1019 19 or or CC cord-023095-4dannjjm 1019 20 50 50 CD cord-023095-4dannjjm 1019 21 mm mm NNS cord-023095-4dannjjm 1019 22 / / SYM cord-023095-4dannjjm 1019 23 s s NN cord-023095-4dannjjm 1019 24 ( ( -LRB- cord-023095-4dannjjm 1019 25 n n NN cord-023095-4dannjjm 1019 26 5 5 CD cord-023095-4dannjjm 1019 27 246 246 CD cord-023095-4dannjjm 1019 28 ) ) -RRB- cord-023095-4dannjjm 1019 29 using use VBG cord-023095-4dannjjm 1019 30 a a DT cord-023095-4dannjjm 1019 31 multiparameter multiparameter NN cord-023095-4dannjjm 1019 32 monitor monitor NN cord-023095-4dannjjm 1019 33 ( ( -LRB- cord-023095-4dannjjm 1019 34 Datascope Datascope NNP cord-023095-4dannjjm 1019 35 Passport Passport NNP cord-023095-4dannjjm 1019 36 ) ) -RRB- cord-023095-4dannjjm 1019 37 . . . cord-023095-4dannjjm 1020 1 During during IN cord-023095-4dannjjm 1020 2 the the DT cord-023095-4dannjjm 1020 3 procedure procedure NN cord-023095-4dannjjm 1020 4 , , , cord-023095-4dannjjm 1020 5 the the DT cord-023095-4dannjjm 1020 6 horses horse NNS cord-023095-4dannjjm 1020 7 were be VBD cord-023095-4dannjjm 1020 8 unsedated unsedate VBN cord-023095-4dannjjm 1020 9 , , , cord-023095-4dannjjm 1020 10 standing stand VBG cord-023095-4dannjjm 1020 11 quiet quiet JJ cord-023095-4dannjjm 1020 12 in in IN cord-023095-4dannjjm 1020 13 a a DT cord-023095-4dannjjm 1020 14 box box NN cord-023095-4dannjjm 1020 15 stall stall NN cord-023095-4dannjjm 1020 16 . . . cord-023095-4dannjjm 1021 1 Mean mean JJ cord-023095-4dannjjm 1021 2 HR hr NN cord-023095-4dannjjm 1021 3 over over IN cord-023095-4dannjjm 1021 4 15 15 CD cord-023095-4dannjjm 1021 5 sec sec NNP cord-023095-4dannjjm 1021 6 was be VBD cord-023095-4dannjjm 1021 7 determined determine VBN cord-023095-4dannjjm 1021 8 for for IN cord-023095-4dannjjm 1021 9 each each DT cord-023095-4dannjjm 1021 10 recording recording NN cord-023095-4dannjjm 1021 11 . . . cord-023095-4dannjjm 1022 1 The the DT cord-023095-4dannjjm 1022 2 following follow VBG cord-023095-4dannjjm 1022 3 ECG ECG NNP cord-023095-4dannjjm 1022 4 time time NN cord-023095-4dannjjm 1022 5 intervals interval NNS cord-023095-4dannjjm 1022 6 were be VBD cord-023095-4dannjjm 1022 7 measured measure VBN cord-023095-4dannjjm 1022 8 in in IN cord-023095-4dannjjm 1022 9 triplicate triplicate NN cord-023095-4dannjjm 1022 10 and and CC cord-023095-4dannjjm 1022 11 averaged average VBD cord-023095-4dannjjm 1022 12 for for IN cord-023095-4dannjjm 1022 13 further further JJ cord-023095-4dannjjm 1022 14 analyses analysis NNS cord-023095-4dannjjm 1022 15 : : : cord-023095-4dannjjm 1022 16 PQ pq NN cord-023095-4dannjjm 1022 17 interval interval NN cord-023095-4dannjjm 1022 18 , , , cord-023095-4dannjjm 1022 19 QRS qrs NN cord-023095-4dannjjm 1022 20 duration duration NN cord-023095-4dannjjm 1022 21 , , , cord-023095-4dannjjm 1022 22 QT QT NNP cord-023095-4dannjjm 1022 23 interval interval NN cord-023095-4dannjjm 1022 24 , , , cord-023095-4dannjjm 1022 25 and and CC cord-023095-4dannjjm 1022 26 difference difference NN cord-023095-4dannjjm 1022 27 between between IN cord-023095-4dannjjm 1022 28 QT qt NN cord-023095-4dannjjm 1022 29 and and CC cord-023095-4dannjjm 1022 30 QRS qrs NN cord-023095-4dannjjm 1022 31 ( ( -LRB- cord-023095-4dannjjm 1022 32 QT qt NN cord-023095-4dannjjm 1022 33 - - HYPH cord-023095-4dannjjm 1022 34 QRS qrs NN cord-023095-4dannjjm 1022 35 duration duration NN cord-023095-4dannjjm 1022 36 ) ) -RRB- cord-023095-4dannjjm 1022 37 . . . cord-023095-4dannjjm 1023 1 The the DT cord-023095-4dannjjm 1023 2 relationship relationship NN cord-023095-4dannjjm 1023 3 between between IN cord-023095-4dannjjm 1023 4 HR hr NN cord-023095-4dannjjm 1023 5 , , , cord-023095-4dannjjm 1023 6 ECG ECG NNP cord-023095-4dannjjm 1023 7 time time NN cord-023095-4dannjjm 1023 8 intervals interval NNS cord-023095-4dannjjm 1023 9 , , , cord-023095-4dannjjm 1023 10 and and CC cord-023095-4dannjjm 1023 11 body body NN cord-023095-4dannjjm 1023 12 mass mass NN cord-023095-4dannjjm 1023 13 was be VBD cord-023095-4dannjjm 1023 14 assessed assess VBN cord-023095-4dannjjm 1023 15 using use VBG cord-023095-4dannjjm 1023 16 linear linear JJ cord-023095-4dannjjm 1023 17 regression regression NN cord-023095-4dannjjm 1023 18 analyses analysis NNS cord-023095-4dannjjm 1023 19 . . . cord-023095-4dannjjm 1024 1 Normal normal JJ cord-023095-4dannjjm 1024 2 ranges range NNS cord-023095-4dannjjm 1024 3 ( ( -LRB- cord-023095-4dannjjm 1024 4 2.5 2.5 CD cord-023095-4dannjjm 1024 5 % % NN cord-023095-4dannjjm 1024 6 to to IN cord-023095-4dannjjm 1024 7 97.5 97.5 CD cord-023095-4dannjjm 1024 8 % % NN cord-023095-4dannjjm 1024 9 percentile percentile NN cord-023095-4dannjjm 1024 10 ) ) -RRB- cord-023095-4dannjjm 1024 11 were be VBD cord-023095-4dannjjm 1024 12 calculated calculate VBN cord-023095-4dannjjm 1024 13 for for IN cord-023095-4dannjjm 1024 14 5 5 CD cord-023095-4dannjjm 1024 15 different different JJ cord-023095-4dannjjm 1024 16 weight weight NN cord-023095-4dannjjm 1024 17 groups group NNS cord-023095-4dannjjm 1024 18 . . . cord-023095-4dannjjm 1025 1 The the DT cord-023095-4dannjjm 1025 2 level level NN cord-023095-4dannjjm 1025 3 of of IN cord-023095-4dannjjm 1025 4 significance significance NN cord-023095-4dannjjm 1025 5 was be VBD cord-023095-4dannjjm 1025 6 p p NN cord-023095-4dannjjm 1025 7 5 5 CD cord-023095-4dannjjm 1025 8 0.05 0.05 CD cord-023095-4dannjjm 1025 9 . . . cord-023095-4dannjjm 1026 1 Heart heart NN cord-023095-4dannjjm 1026 2 rate rate NN cord-023095-4dannjjm 1026 3 was be VBD cord-023095-4dannjjm 1026 4 inversely inversely RB cord-023095-4dannjjm 1026 5 related relate VBN cord-023095-4dannjjm 1026 6 to to IN cord-023095-4dannjjm 1026 7 body body NN cord-023095-4dannjjm 1026 8 mass mass NN cord-023095-4dannjjm 1026 9 ( ( -LRB- cord-023095-4dannjjm 1026 10 p p NN cord-023095-4dannjjm 1026 11 o o NN cord-023095-4dannjjm 1027 1 0.0001 0.0001 CD cord-023095-4dannjjm 1027 2 , , , cord-023095-4dannjjm 1027 3 R r NN cord-023095-4dannjjm 1027 4 2 2 CD cord-023095-4dannjjm 1027 5 5 5 CD cord-023095-4dannjjm 1027 6 0.122 0.122 CD cord-023095-4dannjjm 1027 7 ) ) -RRB- cord-023095-4dannjjm 1027 8 . . . cord-023095-4dannjjm 1028 1 The the DT cord-023095-4dannjjm 1028 2 PQ PQ NNP cord-023095-4dannjjm 1028 3 interval interval NN cord-023095-4dannjjm 1028 4 ( ( -LRB- cord-023095-4dannjjm 1028 5 p p NN cord-023095-4dannjjm 1028 6 o o NN cord-023095-4dannjjm 1028 7 0.0001 0.0001 CD cord-023095-4dannjjm 1028 8 , , , cord-023095-4dannjjm 1028 9 R r NN cord-023095-4dannjjm 1028 10 2 2 CD cord-023095-4dannjjm 1028 11 5 5 CD cord-023095-4dannjjm 1028 12 0.413 0.413 CD cord-023095-4dannjjm 1028 13 ) ) -RRB- cord-023095-4dannjjm 1028 14 , , , cord-023095-4dannjjm 1028 15 QRS qrs NN cord-023095-4dannjjm 1028 16 duration duration NN cord-023095-4dannjjm 1028 17 ( ( -LRB- cord-023095-4dannjjm 1028 18 p p NN cord-023095-4dannjjm 1028 19 o o NN cord-023095-4dannjjm 1028 20 0.0001 0.0001 CD cord-023095-4dannjjm 1028 21 , , , cord-023095-4dannjjm 1028 22 R r NN cord-023095-4dannjjm 1028 23 2 2 CD cord-023095-4dannjjm 1028 24 5 5 CD cord-023095-4dannjjm 1028 25 0.147 0.147 CD cord-023095-4dannjjm 1028 26 ) ) -RRB- cord-023095-4dannjjm 1028 27 , , , cord-023095-4dannjjm 1028 28 QT QT NNP cord-023095-4dannjjm 1028 29 interval interval NN cord-023095-4dannjjm 1028 30 ( ( -LRB- cord-023095-4dannjjm 1028 31 p p NN cord-023095-4dannjjm 1028 32 o o NN cord-023095-4dannjjm 1028 33 0.0001 0.0001 CD cord-023095-4dannjjm 1028 34 , , , cord-023095-4dannjjm 1028 35 R r NN cord-023095-4dannjjm 1028 36 2 2 CD cord-023095-4dannjjm 1028 37 5 5 CD cord-023095-4dannjjm 1028 38 0.089 0.089 CD cord-023095-4dannjjm 1028 39 ) ) -RRB- cord-023095-4dannjjm 1028 40 , , , cord-023095-4dannjjm 1028 41 and and CC cord-023095-4dannjjm 1028 42 QT qt NN cord-023095-4dannjjm 1028 43 - - HYPH cord-023095-4dannjjm 1028 44 QRS qrs NN cord-023095-4dannjjm 1028 45 duration duration NN cord-023095-4dannjjm 1029 1 ( ( -LRB- cord-023095-4dannjjm 1029 2 p p NN cord-023095-4dannjjm 1029 3 o o NN cord-023095-4dannjjm 1030 1 0.0001 0.0001 CD cord-023095-4dannjjm 1030 2 , , , cord-023095-4dannjjm 1030 3 R r NN cord-023095-4dannjjm 1030 4 2 2 CD cord-023095-4dannjjm 1030 5 5 5 CD cord-023095-4dannjjm 1030 6 0.028 0.028 CD cord-023095-4dannjjm 1030 7 ) ) -RRB- cord-023095-4dannjjm 1030 8 were be VBD cord-023095-4dannjjm 1030 9 directly directly RB cord-023095-4dannjjm 1030 10 related relate VBN cord-023095-4dannjjm 1030 11 to to IN cord-023095-4dannjjm 1030 12 body body NN cord-023095-4dannjjm 1030 13 mass mass NN cord-023095-4dannjjm 1030 14 . . . cord-023095-4dannjjm 1031 1 Normal normal JJ cord-023095-4dannjjm 1031 2 ranges range NNS cord-023095-4dannjjm 1031 3 for for IN cord-023095-4dannjjm 1031 4 HR hr NN cord-023095-4dannjjm 1031 5 , , , cord-023095-4dannjjm 1031 6 PQ PQ NNP cord-023095-4dannjjm 1031 7 , , , cord-023095-4dannjjm 1031 8 QRS QRS NNP cord-023095-4dannjjm 1031 9 , , , cord-023095-4dannjjm 1031 10 and and CC cord-023095-4dannjjm 1031 11 QT qt NN cord-023095-4dannjjm 1031 12 within within IN cord-023095-4dannjjm 1031 13 the the DT cord-023095-4dannjjm 1031 14 different different JJ cord-023095-4dannjjm 1031 15 weight weight NN cord-023095-4dannjjm 1031 16 groups group NNS cord-023095-4dannjjm 1031 17 were be VBD cord-023095-4dannjjm 1031 18 36 36 CD cord-023095-4dannjjm 1031 19 - - SYM cord-023095-4dannjjm 1031 20 64 64 CD cord-023095-4dannjjm 1031 21 bpm bpm NN cord-023095-4dannjjm 1031 22 , , , cord-023095-4dannjjm 1031 23 107 107 CD cord-023095-4dannjjm 1031 24 - - SYM cord-023095-4dannjjm 1031 25 230 230 CD cord-023095-4dannjjm 1031 26 ms m NNS cord-023095-4dannjjm 1031 27 , , , cord-023095-4dannjjm 1031 28 60 60 CD cord-023095-4dannjjm 1031 29 - - SYM cord-023095-4dannjjm 1031 30 127 127 CD cord-023095-4dannjjm 1031 31 ms m NNS cord-023095-4dannjjm 1031 32 , , , cord-023095-4dannjjm 1031 33 360 360 CD cord-023095-4dannjjm 1031 34 - - HYPH cord-023095-4dannjjm 1031 35 510 510 CD cord-023095-4dannjjm 1031 36 ms ms NNP cord-023095-4dannjjm 1031 37 ( ( -LRB- cord-023095-4dannjjm 1031 38 o200 o200 NNP cord-023095-4dannjjm 1031 39 kg kg NNP cord-023095-4dannjjm 1031 40 ) ) -RRB- cord-023095-4dannjjm 1031 41 ; ; : cord-023095-4dannjjm 1031 42 28 28 CD cord-023095-4dannjjm 1031 43 - - SYM cord-023095-4dannjjm 1031 44 68 68 CD cord-023095-4dannjjm 1031 45 bpm bpm NN cord-023095-4dannjjm 1031 46 , , , cord-023095-4dannjjm 1031 47 162 162 CD cord-023095-4dannjjm 1031 48 - - SYM cord-023095-4dannjjm 1031 49 319 319 CD cord-023095-4dannjjm 1031 50 ms m NNS cord-023095-4dannjjm 1031 51 , , , cord-023095-4dannjjm 1031 52 74 74 CD cord-023095-4dannjjm 1031 53 - - SYM cord-023095-4dannjjm 1031 54 155 155 CD cord-023095-4dannjjm 1031 55 ms m NNS cord-023095-4dannjjm 1031 56 , , , cord-023095-4dannjjm 1031 57 362 362 CD cord-023095-4dannjjm 1031 58 - - SYM cord-023095-4dannjjm 1031 59 610 610 CD cord-023095-4dannjjm 1031 60 ms ms NNP cord-023095-4dannjjm 1031 61 ( ( -LRB- cord-023095-4dannjjm 1031 62 200 200 CD cord-023095-4dannjjm 1031 63 - - SYM cord-023095-4dannjjm 1031 64 399 399 CD cord-023095-4dannjjm 1031 65 kg kg NN cord-023095-4dannjjm 1031 66 ) ) -RRB- cord-023095-4dannjjm 1031 67 ; ; : cord-023095-4dannjjm 1031 68 28 28 CD cord-023095-4dannjjm 1031 69 - - SYM cord-023095-4dannjjm 1031 70 60 60 CD cord-023095-4dannjjm 1031 71 bpm bpm NN cord-023095-4dannjjm 1031 72 , , , cord-023095-4dannjjm 1031 73 211 211 CD cord-023095-4dannjjm 1031 74 - - SYM cord-023095-4dannjjm 1031 75 423 423 CD cord-023095-4dannjjm 1031 76 ms m NNS cord-023095-4dannjjm 1031 77 , , , cord-023095-4dannjjm 1031 78 89 89 CD cord-023095-4dannjjm 1031 79 - - SYM cord-023095-4dannjjm 1031 80 147 147 CD cord-023095-4dannjjm 1031 81 ms ms NNP cord-023095-4dannjjm 1031 82 , , , cord-023095-4dannjjm 1031 83 390 390 CD cord-023095-4dannjjm 1031 84 - - SYM cord-023095-4dannjjm 1031 85 581 581 CD cord-023095-4dannjjm 1031 86 ms ms NN cord-023095-4dannjjm 1031 87 ( ( -LRB- cord-023095-4dannjjm 1031 88 400 400 CD cord-023095-4dannjjm 1031 89 - - SYM cord-023095-4dannjjm 1031 90 599 599 CD cord-023095-4dannjjm 1031 91 kg kg NN cord-023095-4dannjjm 1031 92 ) ) -RRB- cord-023095-4dannjjm 1031 93 ; ; : cord-023095-4dannjjm 1031 94 28 28 CD cord-023095-4dannjjm 1031 95 - - SYM cord-023095-4dannjjm 1031 96 54 54 CD cord-023095-4dannjjm 1031 97 bpm bpm NNS cord-023095-4dannjjm 1031 98 , , , cord-023095-4dannjjm 1031 99 220 220 CD cord-023095-4dannjjm 1031 100 - - SYM cord-023095-4dannjjm 1031 101 380 380 CD cord-023095-4dannjjm 1031 102 ms m NNS cord-023095-4dannjjm 1031 103 , , , cord-023095-4dannjjm 1031 104 87 87 CD cord-023095-4dannjjm 1031 105 - - SYM cord-023095-4dannjjm 1031 106 150 150 CD cord-023095-4dannjjm 1031 107 ms m NNS cord-023095-4dannjjm 1031 108 , , , cord-023095-4dannjjm 1031 109 367 367 CD cord-023095-4dannjjm 1031 110 - - SYM cord-023095-4dannjjm 1031 111 587 587 CD cord-023095-4dannjjm 1031 112 ms m NNS cord-023095-4dannjjm 1031 113 ( ( -LRB- cord-023095-4dannjjm 1031 114 600 600 CD cord-023095-4dannjjm 1031 115 - - SYM cord-023095-4dannjjm 1031 116 799 799 CD cord-023095-4dannjjm 1031 117 kg kg NN cord-023095-4dannjjm 1031 118 ) ) -RRB- cord-023095-4dannjjm 1031 119 ; ; : cord-023095-4dannjjm 1031 120 and and CC cord-023095-4dannjjm 1031 121 24 24 CD cord-023095-4dannjjm 1031 122 - - SYM cord-023095-4dannjjm 1031 123 52 52 CD cord-023095-4dannjjm 1031 124 bpm bpm NN cord-023095-4dannjjm 1031 125 , , , cord-023095-4dannjjm 1032 1 240 240 CD cord-023095-4dannjjm 1032 2 - - SYM cord-023095-4dannjjm 1032 3 463 463 CD cord-023095-4dannjjm 1032 4 ms m NNS cord-023095-4dannjjm 1032 5 , , , cord-023095-4dannjjm 1032 6 87 87 CD cord-023095-4dannjjm 1032 7 - - SYM cord-023095-4dannjjm 1032 8 140 140 CD cord-023095-4dannjjm 1032 9 ms m NNS cord-023095-4dannjjm 1032 10 , , , cord-023095-4dannjjm 1032 11 437 437 CD cord-023095-4dannjjm 1032 12 - - SYM cord-023095-4dannjjm 1032 13 533 533 CD cord-023095-4dannjjm 1032 14 ms ms NNP cord-023095-4dannjjm 1032 15 ( ( -LRB- cord-023095-4dannjjm 1032 16 4 4 CD cord-023095-4dannjjm 1032 17 799 799 CD cord-023095-4dannjjm 1032 18 kg kg NN cord-023095-4dannjjm 1032 19 ) ) -RRB- cord-023095-4dannjjm 1032 20 . . . cord-023095-4dannjjm 1033 1 We -PRON- PRP cord-023095-4dannjjm 1033 2 conclude conclude VBP cord-023095-4dannjjm 1033 3 that that IN cord-023095-4dannjjm 1033 4 in in IN cord-023095-4dannjjm 1033 5 healthy healthy JJ cord-023095-4dannjjm 1033 6 horses horse NNS cord-023095-4dannjjm 1033 7 there there EX cord-023095-4dannjjm 1033 8 is be VBZ cord-023095-4dannjjm 1033 9 a a DT cord-023095-4dannjjm 1033 10 significant significant JJ cord-023095-4dannjjm 1033 11 but but CC cord-023095-4dannjjm 1033 12 weak weak JJ cord-023095-4dannjjm 1033 13 relationship relationship NN cord-023095-4dannjjm 1033 14 between between IN cord-023095-4dannjjm 1033 15 body body NN cord-023095-4dannjjm 1033 16 mass mass NN cord-023095-4dannjjm 1033 17 and and CC cord-023095-4dannjjm 1033 18 HR HR NNP cord-023095-4dannjjm 1033 19 and and CC cord-023095-4dannjjm 1033 20 between between IN cord-023095-4dannjjm 1033 21 body body NN cord-023095-4dannjjm 1033 22 mass mass NN cord-023095-4dannjjm 1033 23 and and CC cord-023095-4dannjjm 1033 24 ECG ECG NNP cord-023095-4dannjjm 1033 25 time time NN cord-023095-4dannjjm 1033 26 intervals interval NNS cord-023095-4dannjjm 1033 27 , , , cord-023095-4dannjjm 1033 28 respectively respectively RB cord-023095-4dannjjm 1033 29 . . . cord-023095-4dannjjm 1034 1 This this DT cord-023095-4dannjjm 1034 2 study study NN cord-023095-4dannjjm 1034 3 therefore therefore RB cord-023095-4dannjjm 1034 4 supports support VBZ cord-023095-4dannjjm 1034 5 the the DT cord-023095-4dannjjm 1034 6 hypothesis hypothesis NN cord-023095-4dannjjm 1034 7 that that IN cord-023095-4dannjjm 1034 8 within within IN cord-023095-4dannjjm 1034 9 the the DT cord-023095-4dannjjm 1034 10 equine equine JJ cord-023095-4dannjjm 1034 11 species specie NNS cord-023095-4dannjjm 1034 12 , , , cord-023095-4dannjjm 1034 13 small small JJ cord-023095-4dannjjm 1034 14 breeds breed NNS cord-023095-4dannjjm 1034 15 have have VBP cord-023095-4dannjjm 1034 16 faster fast JJR cord-023095-4dannjjm 1034 17 heart heart NN cord-023095-4dannjjm 1034 18 rates rate NNS cord-023095-4dannjjm 1034 19 and and CC cord-023095-4dannjjm 1034 20 shorter short JJR cord-023095-4dannjjm 1034 21 ECG ECG NNP cord-023095-4dannjjm 1034 22 time time NN cord-023095-4dannjjm 1034 23 intervals interval NNS cord-023095-4dannjjm 1034 24 than than IN cord-023095-4dannjjm 1034 25 large large JJ cord-023095-4dannjjm 1034 26 breeds breed NNS cord-023095-4dannjjm 1034 27 . . . cord-023095-4dannjjm 1035 1 Therefore therefore RB cord-023095-4dannjjm 1035 2 , , , cord-023095-4dannjjm 1035 3 body body NN cord-023095-4dannjjm 1035 4 mass mass NN cord-023095-4dannjjm 1035 5 has have VBZ cord-023095-4dannjjm 1035 6 to to TO cord-023095-4dannjjm 1035 7 be be VB cord-023095-4dannjjm 1035 8 considered consider VBN cord-023095-4dannjjm 1035 9 when when WRB cord-023095-4dannjjm 1035 10 comparing compare VBG cord-023095-4dannjjm 1035 11 HR HR NNP cord-023095-4dannjjm 1035 12 and and CC cord-023095-4dannjjm 1035 13 ECG ECG NNP cord-023095-4dannjjm 1035 14 time time NN cord-023095-4dannjjm 1035 15 intervals interval NNS cord-023095-4dannjjm 1035 16 to to IN cord-023095-4dannjjm 1035 17 normal normal JJ cord-023095-4dannjjm 1035 18 ranges range NNS cord-023095-4dannjjm 1035 19 in in IN cord-023095-4dannjjm 1035 20 horses horse NNS cord-023095-4dannjjm 1035 21 . . . cord-023095-4dannjjm 1036 1 Horses horse NNS cord-023095-4dannjjm 1036 2 with with IN cord-023095-4dannjjm 1036 3 pituitary pituitary NNP cord-023095-4dannjjm 1036 4 pars pars NNP cord-023095-4dannjjm 1036 5 intermedia intermedia NN cord-023095-4dannjjm 1036 6 dysfunction dysfunction NN cord-023095-4dannjjm 1036 7 ( ( -LRB- cord-023095-4dannjjm 1036 8 PPID PPID NNP cord-023095-4dannjjm 1036 9 ) ) -RRB- cord-023095-4dannjjm 1036 10 often often RB cord-023095-4dannjjm 1036 11 have have VBP cord-023095-4dannjjm 1036 12 elevated elevate VBN cord-023095-4dannjjm 1036 13 plasma plasma NN cord-023095-4dannjjm 1036 14 ACTH ACTH NNP cord-023095-4dannjjm 1036 15 concentrations concentration NNS cord-023095-4dannjjm 1036 16 . . . cord-023095-4dannjjm 1037 1 However however RB cord-023095-4dannjjm 1037 2 , , , cord-023095-4dannjjm 1037 3 PPIDaffected ppidaffected JJ cord-023095-4dannjjm 1037 4 horses horse NNS cord-023095-4dannjjm 1037 5 rarely rarely RB cord-023095-4dannjjm 1037 6 have have VBP cord-023095-4dannjjm 1037 7 resting rest VBG cord-023095-4dannjjm 1037 8 serum serum NN cord-023095-4dannjjm 1037 9 cortisol cortisol NN cord-023095-4dannjjm 1037 10 levels level NNS cord-023095-4dannjjm 1037 11 above above IN cord-023095-4dannjjm 1037 12 the the DT cord-023095-4dannjjm 1037 13 reference reference NN cord-023095-4dannjjm 1037 14 range range NN cord-023095-4dannjjm 1037 15 or or CC cord-023095-4dannjjm 1037 16 adrenal adrenal JJ cord-023095-4dannjjm 1037 17 hyperplasia hyperplasia NN cord-023095-4dannjjm 1037 18 . . . cord-023095-4dannjjm 1038 1 We -PRON- PRP cord-023095-4dannjjm 1038 2 hypothesized hypothesize VBD cord-023095-4dannjjm 1038 3 that that IN cord-023095-4dannjjm 1038 4 this this DT cord-023095-4dannjjm 1038 5 apparent apparent JJ cord-023095-4dannjjm 1038 6 dissociation dissociation NN cord-023095-4dannjjm 1038 7 between between IN cord-023095-4dannjjm 1038 8 plasma plasma NN cord-023095-4dannjjm 1038 9 ACTH ACTH NNP cord-023095-4dannjjm 1038 10 levels level NNS cord-023095-4dannjjm 1038 11 and and CC cord-023095-4dannjjm 1038 12 adrenal adrenal JJ cord-023095-4dannjjm 1038 13 response response NN cord-023095-4dannjjm 1038 14 in in IN cord-023095-4dannjjm 1038 15 horses horse NNS cord-023095-4dannjjm 1038 16 with with IN cord-023095-4dannjjm 1038 17 PPID PPID NNP cord-023095-4dannjjm 1038 18 is be VBZ cord-023095-4dannjjm 1038 19 due due JJ cord-023095-4dannjjm 1038 20 to to IN cord-023095-4dannjjm 1038 21 the the DT cord-023095-4dannjjm 1038 22 secretion secretion NN cord-023095-4dannjjm 1038 23 of of IN cord-023095-4dannjjm 1038 24 ACTH ACTH NNP cord-023095-4dannjjm 1038 25 that that WDT cord-023095-4dannjjm 1038 26 is be VBZ cord-023095-4dannjjm 1038 27 less less RBR cord-023095-4dannjjm 1038 28 biologically biologically RB cord-023095-4dannjjm 1038 29 active active JJ cord-023095-4dannjjm 1038 30 than than IN cord-023095-4dannjjm 1038 31 that that DT cord-023095-4dannjjm 1038 32 from from IN cord-023095-4dannjjm 1038 33 normal normal JJ cord-023095-4dannjjm 1038 34 horses horse NNS cord-023095-4dannjjm 1038 35 . . . cord-023095-4dannjjm 1039 1 To to TO cord-023095-4dannjjm 1039 2 test test VB cord-023095-4dannjjm 1039 3 our -PRON- PRP$ cord-023095-4dannjjm 1039 4 hypothesis hypothesis NN cord-023095-4dannjjm 1039 5 , , , cord-023095-4dannjjm 1039 6 a a DT cord-023095-4dannjjm 1039 7 bioassay bioassay NN cord-023095-4dannjjm 1039 8 to to TO cord-023095-4dannjjm 1039 9 evaluate evaluate VB cord-023095-4dannjjm 1039 10 ACTH ACTH NNP cord-023095-4dannjjm 1039 11 activity activity NN cord-023095-4dannjjm 1039 12 was be VBD cord-023095-4dannjjm 1039 13 developed develop VBN cord-023095-4dannjjm 1039 14 . . . cord-023095-4dannjjm 1040 1 Adrenocortical adrenocortical JJ cord-023095-4dannjjm 1040 2 explants explant NNS cord-023095-4dannjjm 1040 3 were be VBD cord-023095-4dannjjm 1040 4 harvested harvest VBN cord-023095-4dannjjm 1040 5 aseptically aseptically RB cord-023095-4dannjjm 1040 6 from from IN cord-023095-4dannjjm 1040 7 normal normal JJ cord-023095-4dannjjm 1040 8 horses horse NNS cord-023095-4dannjjm 1040 9 at at IN cord-023095-4dannjjm 1040 10 euthanasia euthanasia NN cord-023095-4dannjjm 1040 11 and and CC cord-023095-4dannjjm 1040 12 stimulated stimulate VBN cord-023095-4dannjjm 1040 13 with with IN cord-023095-4dannjjm 1040 14 plasma plasma NN cord-023095-4dannjjm 1040 15 from from IN cord-023095-4dannjjm 1040 16 healthy healthy JJ cord-023095-4dannjjm 1040 17 ( ( -LRB- cord-023095-4dannjjm 1040 18 n n NN cord-023095-4dannjjm 1040 19 5 5 CD cord-023095-4dannjjm 1040 20 9 9 CD cord-023095-4dannjjm 1040 21 ) ) -RRB- cord-023095-4dannjjm 1040 22 and and CC cord-023095-4dannjjm 1040 23 PPID PPID NNP cord-023095-4dannjjm 1040 24 - - HYPH cord-023095-4dannjjm 1040 25 affected affect VBN cord-023095-4dannjjm 1040 26 horses horse NNS cord-023095-4dannjjm 1040 27 ( ( -LRB- cord-023095-4dannjjm 1040 28 n n NN cord-023095-4dannjjm 1040 29 5 5 CD cord-023095-4dannjjm 1040 30 11 11 CD cord-023095-4dannjjm 1040 31 ) ) -RRB- cord-023095-4dannjjm 1040 32 . . . cord-023095-4dannjjm 1041 1 The the DT cord-023095-4dannjjm 1041 2 assay assay NN cord-023095-4dannjjm 1041 3 was be VBD cord-023095-4dannjjm 1041 4 performed perform VBN cord-023095-4dannjjm 1041 5 three three CD cord-023095-4dannjjm 1041 6 times time NNS cord-023095-4dannjjm 1041 7 with with IN cord-023095-4dannjjm 1041 8 explants explant NNS cord-023095-4dannjjm 1041 9 obtained obtain VBN cord-023095-4dannjjm 1041 10 from from IN cord-023095-4dannjjm 1041 11 different different JJ cord-023095-4dannjjm 1041 12 horses horse NNS cord-023095-4dannjjm 1041 13 . . . cord-023095-4dannjjm 1042 1 Cortisol cortisol NN cord-023095-4dannjjm 1042 2 secreted secrete VBN cord-023095-4dannjjm 1042 3 by by IN cord-023095-4dannjjm 1042 4 the the DT cord-023095-4dannjjm 1042 5 explants explant NNS cord-023095-4dannjjm 1042 6 and and CC cord-023095-4dannjjm 1042 7 plasma plasma NN cord-023095-4dannjjm 1042 8 ACTH ACTH NNP cord-023095-4dannjjm 1042 9 levels level NNS cord-023095-4dannjjm 1042 10 were be VBD cord-023095-4dannjjm 1042 11 measured measure VBN cord-023095-4dannjjm 1042 12 with with IN cord-023095-4dannjjm 1042 13 commercially commercially RB cord-023095-4dannjjm 1042 14 available available JJ cord-023095-4dannjjm 1042 15 radioimmunoassays radioimmunoassay NNS cord-023095-4dannjjm 1042 16 . . . cord-023095-4dannjjm 1043 1 Cortisol cortisol NN cord-023095-4dannjjm 1043 2 secretion secretion NN cord-023095-4dannjjm 1043 3 stimulated stimulate VBN cord-023095-4dannjjm 1043 4 by by IN cord-023095-4dannjjm 1043 5 each each DT cord-023095-4dannjjm 1043 6 sample sample NN cord-023095-4dannjjm 1043 7 was be VBD cord-023095-4dannjjm 1043 8 standardized standardize VBN cord-023095-4dannjjm 1043 9 to to IN cord-023095-4dannjjm 1043 10 the the DT cord-023095-4dannjjm 1043 11 respective respective JJ cord-023095-4dannjjm 1043 12 explant explant NN cord-023095-4dannjjm 1043 13 protein protein NN cord-023095-4dannjjm 1043 14 concentration concentration NN cord-023095-4dannjjm 1043 15 . . . cord-023095-4dannjjm 1044 1 Cortisol cortisol NN cord-023095-4dannjjm 1044 2 data datum NNS cord-023095-4dannjjm 1044 3 was be VBD cord-023095-4dannjjm 1044 4 normalized normalize VBN cord-023095-4dannjjm 1044 5 for for IN cord-023095-4dannjjm 1044 6 ACTH ACTH NNP cord-023095-4dannjjm 1044 7 concentration concentration NN cord-023095-4dannjjm 1044 8 in in IN cord-023095-4dannjjm 1044 9 each each DT cord-023095-4dannjjm 1044 10 plasma plasma NN cord-023095-4dannjjm 1044 11 sample sample NN cord-023095-4dannjjm 1044 12 and and CC cord-023095-4dannjjm 1044 13 expressed express VBD cord-023095-4dannjjm 1044 14 as as IN cord-023095-4dannjjm 1044 15 a a DT cord-023095-4dannjjm 1044 16 cortisol cortisol NN cord-023095-4dannjjm 1044 17 : : : cord-023095-4dannjjm 1044 18 protein protein NN cord-023095-4dannjjm 1044 19 : : : cord-023095-4dannjjm 1044 20 ACTH ACTH NNP cord-023095-4dannjjm 1044 21 ratio ratio NN cord-023095-4dannjjm 1044 22 . . . cord-023095-4dannjjm 1045 1 Ratios ratio NNS cord-023095-4dannjjm 1045 2 from from IN cord-023095-4dannjjm 1045 3 horses horse NNS cord-023095-4dannjjm 1045 4 with with IN cord-023095-4dannjjm 1045 5 PPID PPID NNP cord-023095-4dannjjm 1045 6 and and CC cord-023095-4dannjjm 1045 7 normal normal JJ cord-023095-4dannjjm 1045 8 horses horse NNS cord-023095-4dannjjm 1045 9 were be VBD cord-023095-4dannjjm 1045 10 compared compare VBN cord-023095-4dannjjm 1045 11 by by IN cord-023095-4dannjjm 1045 12 unpaired unpaired JJ cord-023095-4dannjjm 1045 13 t t NN cord-023095-4dannjjm 1045 14 - - HYPH cord-023095-4dannjjm 1045 15 test test NN cord-023095-4dannjjm 1045 16 . . . cord-023095-4dannjjm 1046 1 Horses horse NNS cord-023095-4dannjjm 1046 2 with with IN cord-023095-4dannjjm 1046 3 PPID PPID NNP cord-023095-4dannjjm 1046 4 had have VBD cord-023095-4dannjjm 1046 5 significantly significantly RB cord-023095-4dannjjm 1046 6 lower low JJR cord-023095-4dannjjm 1046 7 cortisol cortisol NN cord-023095-4dannjjm 1046 8 : : : cord-023095-4dannjjm 1046 9 protein protein NN cord-023095-4dannjjm 1046 10 : : : cord-023095-4dannjjm 1046 11 ACTH ACTH NNP cord-023095-4dannjjm 1046 12 ratios ratio NNS cord-023095-4dannjjm 1046 13 compared compare VBN cord-023095-4dannjjm 1046 14 to to IN cord-023095-4dannjjm 1046 15 normal normal JJ cord-023095-4dannjjm 1046 16 horses horse NNS cord-023095-4dannjjm 1046 17 . . . cord-023095-4dannjjm 1047 1 ( ( -LRB- cord-023095-4dannjjm 1047 2 Assay assay NN cord-023095-4dannjjm 1047 3 1 1 CD cord-023095-4dannjjm 1047 4 : : : cord-023095-4dannjjm 1047 5 0.06 0.06 CD cord-023095-4dannjjm 1047 6 AE AE NNP cord-023095-4dannjjm 1047 7 0.04 0.04 CD cord-023095-4dannjjm 1047 8 vs. vs. NN cord-023095-4dannjjm 1047 9 0.33 0.33 CD cord-023095-4dannjjm 1047 10 AE AE NNP cord-023095-4dannjjm 1047 11 0.11 0.11 CD cord-023095-4dannjjm 1047 12 , , , cord-023095-4dannjjm 1047 13 P p NN cord-023095-4dannjjm 1047 14 o o NN cord-023095-4dannjjm 1047 15 0.001 0.001 CD cord-023095-4dannjjm 1047 16 ; ; : cord-023095-4dannjjm 1047 17 Assay assay NN cord-023095-4dannjjm 1047 18 2 2 CD cord-023095-4dannjjm 1047 19 : : : cord-023095-4dannjjm 1047 20 0.06 0.06 CD cord-023095-4dannjjm 1047 21 AE AE NNP cord-023095-4dannjjm 1047 22 0.04 0.04 CD cord-023095-4dannjjm 1047 23 vs. vs. NN cord-023095-4dannjjm 1047 24 0.30 0.30 CD cord-023095-4dannjjm 1047 25 AE AE NNP cord-023095-4dannjjm 1047 26 0.10 0.10 CD cord-023095-4dannjjm 1047 27 , , , cord-023095-4dannjjm 1047 28 P p NN cord-023095-4dannjjm 1047 29 o o NN cord-023095-4dannjjm 1047 30 0.001 0.001 CD cord-023095-4dannjjm 1047 31 ; ; : cord-023095-4dannjjm 1047 32 Assay assay NN cord-023095-4dannjjm 1047 33 3 3 CD cord-023095-4dannjjm 1047 34 : : : cord-023095-4dannjjm 1047 35 0.07 0.07 CD cord-023095-4dannjjm 1047 36 AE AE NNP cord-023095-4dannjjm 1047 37 0.06 0.06 CD cord-023095-4dannjjm 1047 38 vs. vs. NN cord-023095-4dannjjm 1047 39 0.20 0.20 CD cord-023095-4dannjjm 1047 40 AE AE NNP cord-023095-4dannjjm 1047 41 0.13 0.13 CD cord-023095-4dannjjm 1047 42 , , , cord-023095-4dannjjm 1047 43 P p NN cord-023095-4dannjjm 1047 44 o o NN cord-023095-4dannjjm 1047 45 0.01 0.01 CD cord-023095-4dannjjm 1047 46 ) ) -RRB- cord-023095-4dannjjm 1047 47 . . . cord-023095-4dannjjm 1048 1 These these DT cord-023095-4dannjjm 1048 2 results result NNS cord-023095-4dannjjm 1048 3 suggest suggest VBP cord-023095-4dannjjm 1048 4 that that IN cord-023095-4dannjjm 1048 5 plasma plasma NN cord-023095-4dannjjm 1048 6 ACTH ACTH NNP cord-023095-4dannjjm 1048 7 from from IN cord-023095-4dannjjm 1048 8 PPID PPID NNP cord-023095-4dannjjm 1048 9 horses horse NNS cord-023095-4dannjjm 1048 10 is be VBZ cord-023095-4dannjjm 1048 11 less less RBR cord-023095-4dannjjm 1048 12 biologically biologically RB cord-023095-4dannjjm 1048 13 active active JJ cord-023095-4dannjjm 1048 14 than than IN cord-023095-4dannjjm 1048 15 plasma plasma NN cord-023095-4dannjjm 1048 16 ACTH ACTH NNP cord-023095-4dannjjm 1048 17 from from IN cord-023095-4dannjjm 1048 18 normal normal JJ cord-023095-4dannjjm 1048 19 horses horse NNS cord-023095-4dannjjm 1048 20 . . . cord-023095-4dannjjm 1049 1 Our -PRON- PRP$ cord-023095-4dannjjm 1049 2 findings finding NNS cord-023095-4dannjjm 1049 3 give give VBP cord-023095-4dannjjm 1049 4 further further JJ cord-023095-4dannjjm 1049 5 insight insight NN cord-023095-4dannjjm 1049 6 into into IN cord-023095-4dannjjm 1049 7 the the DT cord-023095-4dannjjm 1049 8 pathophysiology pathophysiology NN cord-023095-4dannjjm 1049 9 of of IN cord-023095-4dannjjm 1049 10 PPID PPID NNP cord-023095-4dannjjm 1049 11 and and CC cord-023095-4dannjjm 1049 12 may may MD cord-023095-4dannjjm 1049 13 aid aid VB cord-023095-4dannjjm 1049 14 in in IN cord-023095-4dannjjm 1049 15 the the DT cord-023095-4dannjjm 1049 16 development development NN cord-023095-4dannjjm 1049 17 of of IN cord-023095-4dannjjm 1049 18 novel novel JJ cord-023095-4dannjjm 1049 19 diagnostic diagnostic JJ cord-023095-4dannjjm 1049 20 testing testing NN cord-023095-4dannjjm 1049 21 protocols protocol NNS cord-023095-4dannjjm 1049 22 . . . cord-023095-4dannjjm 1050 1 An an DT cord-023095-4dannjjm 1050 2 online online JJ cord-023095-4dannjjm 1050 3 survey survey NN cord-023095-4dannjjm 1050 4 was be VBD cord-023095-4dannjjm 1050 5 conducted conduct VBN cord-023095-4dannjjm 1050 6 to to TO cord-023095-4dannjjm 1050 7 determine determine VB cord-023095-4dannjjm 1050 8 perceived perceive VBN cord-023095-4dannjjm 1050 9 needs need NNS cord-023095-4dannjjm 1050 10 of of IN cord-023095-4dannjjm 1050 11 potential potential JJ cord-023095-4dannjjm 1050 12 employers employer NNS cord-023095-4dannjjm 1050 13 of of IN cord-023095-4dannjjm 1050 14 new new JJ cord-023095-4dannjjm 1050 15 ACVIM ACVIM NNP cord-023095-4dannjjm 1050 16 - - HYPH cord-023095-4dannjjm 1050 17 LAIM LAIM NNP cord-023095-4dannjjm 1050 18 diplomates diplomate NNS cord-023095-4dannjjm 1050 19 . . . cord-023095-4dannjjm 1051 1 The the DT cord-023095-4dannjjm 1051 2 survey survey NN cord-023095-4dannjjm 1051 3 was be VBD cord-023095-4dannjjm 1051 4 designed design VBN cord-023095-4dannjjm 1051 5 as as IN cord-023095-4dannjjm 1051 6 the the DT cord-023095-4dannjjm 1051 7 first first JJ cord-023095-4dannjjm 1051 8 step step NN cord-023095-4dannjjm 1051 9 in in IN cord-023095-4dannjjm 1051 10 determining determine VBG cord-023095-4dannjjm 1051 11 what what WP cord-023095-4dannjjm 1051 12 is be VBZ cord-023095-4dannjjm 1051 13 needed need VBN cord-023095-4dannjjm 1051 14 for for IN cord-023095-4dannjjm 1051 15 success success NN cord-023095-4dannjjm 1051 16 in in IN cord-023095-4dannjjm 1051 17 the the DT cord-023095-4dannjjm 1051 18 various various JJ cord-023095-4dannjjm 1051 19 sectors sector NNS cord-023095-4dannjjm 1051 20 of of IN cord-023095-4dannjjm 1051 21 practice practice NN cord-023095-4dannjjm 1051 22 employing employ VBG cord-023095-4dannjjm 1051 23 ACVIM ACVIM NNP cord-023095-4dannjjm 1051 24 - - HYPH cord-023095-4dannjjm 1051 25 LAIM LAIM NNP cord-023095-4dannjjm 1051 26 diplomates diplomate NNS cord-023095-4dannjjm 1051 27 . . . cord-023095-4dannjjm 1052 1 Demographic demographic JJ cord-023095-4dannjjm 1052 2 and and CC cord-023095-4dannjjm 1052 3 background background NN cord-023095-4dannjjm 1052 4 data datum NNS cord-023095-4dannjjm 1052 5 were be VBD cord-023095-4dannjjm 1052 6 collected collect VBN cord-023095-4dannjjm 1052 7 using use VBG cord-023095-4dannjjm 1052 8 questions question NNS cord-023095-4dannjjm 1052 9 and and CC cord-023095-4dannjjm 1052 10 drop drop VB cord-023095-4dannjjm 1052 11 - - HYPH cord-023095-4dannjjm 1052 12 down down RP cord-023095-4dannjjm 1052 13 menus menu NNS cord-023095-4dannjjm 1052 14 on on IN cord-023095-4dannjjm 1052 15 the the DT cord-023095-4dannjjm 1052 16 first first JJ cord-023095-4dannjjm 1052 17 page page NN cord-023095-4dannjjm 1052 18 . . . cord-023095-4dannjjm 1053 1 The the DT cord-023095-4dannjjm 1053 2 survey survey NN cord-023095-4dannjjm 1053 3 evaluated evaluate VBD cord-023095-4dannjjm 1053 4 189 189 CD cord-023095-4dannjjm 1053 5 skills skill NNS cord-023095-4dannjjm 1053 6 or or CC cord-023095-4dannjjm 1053 7 concepts concept NNS cord-023095-4dannjjm 1053 8 in in IN cord-023095-4dannjjm 1053 9 26 26 CD cord-023095-4dannjjm 1053 10 areas area NNS cord-023095-4dannjjm 1053 11 of of IN cord-023095-4dannjjm 1053 12 veterinary veterinary JJ cord-023095-4dannjjm 1053 13 practice practice NN cord-023095-4dannjjm 1053 14 . . . cord-023095-4dannjjm 1054 1 Participants participant NNS cord-023095-4dannjjm 1054 2 answered answer VBD cord-023095-4dannjjm 1054 3 4 4 CD cord-023095-4dannjjm 1054 4 questions question NNS cord-023095-4dannjjm 1054 5 about about IN cord-023095-4dannjjm 1054 6 each each DT cord-023095-4dannjjm 1054 7 skill skill NN cord-023095-4dannjjm 1054 8 or or CC cord-023095-4dannjjm 1054 9 concept concept NN cord-023095-4dannjjm 1054 10 using use VBG cord-023095-4dannjjm 1054 11 drop drop NN cord-023095-4dannjjm 1054 12 - - HYPH cord-023095-4dannjjm 1054 13 down down RP cord-023095-4dannjjm 1054 14 ranked rank VBN cord-023095-4dannjjm 1054 15 lists list NNS cord-023095-4dannjjm 1054 16 . . . cord-023095-4dannjjm 1055 1 Those those DT cord-023095-4dannjjm 1055 2 participants participant NNS cord-023095-4dannjjm 1055 3 that that WDT cord-023095-4dannjjm 1055 4 had have VBD cord-023095-4dannjjm 1055 5 completed complete VBN cord-023095-4dannjjm 1055 6 an an DT cord-023095-4dannjjm 1055 7 ACVIM ACVIM NNP cord-023095-4dannjjm 1055 8 - - HYPH cord-023095-4dannjjm 1055 9 LAIM LAIM NNP cord-023095-4dannjjm 1055 10 training training NN cord-023095-4dannjjm 1055 11 program program NN cord-023095-4dannjjm 1055 12 were be VBD cord-023095-4dannjjm 1055 13 asked ask VBN cord-023095-4dannjjm 1055 14 3 3 CD cord-023095-4dannjjm 1055 15 additional additional JJ cord-023095-4dannjjm 1055 16 questions question NNS cord-023095-4dannjjm 1055 17 about about IN cord-023095-4dannjjm 1055 18 whether whether IN cord-023095-4dannjjm 1055 19 they -PRON- PRP cord-023095-4dannjjm 1055 20 were be VBD cord-023095-4dannjjm 1055 21 taught teach VBN cord-023095-4dannjjm 1055 22 the the DT cord-023095-4dannjjm 1055 23 skill skill NN cord-023095-4dannjjm 1055 24 or or CC cord-023095-4dannjjm 1055 25 concept concept NN cord-023095-4dannjjm 1055 26 during during IN cord-023095-4dannjjm 1055 27 their -PRON- PRP$ cord-023095-4dannjjm 1055 28 own own JJ cord-023095-4dannjjm 1055 29 residency residency NN cord-023095-4dannjjm 1055 30 . . . cord-023095-4dannjjm 1056 1 Data datum NNS cord-023095-4dannjjm 1056 2 were be VBD cord-023095-4dannjjm 1056 3 collated collate VBN cord-023095-4dannjjm 1056 4 and and CC cord-023095-4dannjjm 1056 5 descriptive descriptive JJ cord-023095-4dannjjm 1056 6 statistics statistic NNS cord-023095-4dannjjm 1056 7 calculated calculate VBN cord-023095-4dannjjm 1056 8 . . . cord-023095-4dannjjm 1057 1 The the DT cord-023095-4dannjjm 1057 2 mean mean JJ cord-023095-4dannjjm 1057 3 scores score NNS cord-023095-4dannjjm 1057 4 or or CC cord-023095-4dannjjm 1057 5 frequencies frequency NNS cord-023095-4dannjjm 1057 6 of of IN cord-023095-4dannjjm 1057 7 use use NN cord-023095-4dannjjm 1057 8 for for IN cord-023095-4dannjjm 1057 9 each each DT cord-023095-4dannjjm 1057 10 skills skill NNS cord-023095-4dannjjm 1057 11 or or CC cord-023095-4dannjjm 1057 12 concepts concept NNS cord-023095-4dannjjm 1057 13 were be VBD cord-023095-4dannjjm 1057 14 ranked rank VBN cord-023095-4dannjjm 1057 15 to to TO cord-023095-4dannjjm 1057 16 determine determine VB cord-023095-4dannjjm 1057 17 which which WDT cord-023095-4dannjjm 1057 18 of of IN cord-023095-4dannjjm 1057 19 the the DT cord-023095-4dannjjm 1057 20 skills skill NNS cord-023095-4dannjjm 1057 21 or or CC cord-023095-4dannjjm 1057 22 concepts concept NNS cord-023095-4dannjjm 1057 23 were be VBD cord-023095-4dannjjm 1057 24 most most RBS cord-023095-4dannjjm 1057 25 important important JJ cord-023095-4dannjjm 1057 26 for for IN cord-023095-4dannjjm 1057 27 an an DT cord-023095-4dannjjm 1057 28 entry entry NN cord-023095-4dannjjm 1057 29 - - HYPH cord-023095-4dannjjm 1057 30 level level NN cord-023095-4dannjjm 1057 31 diplomate diplomate NN cord-023095-4dannjjm 1057 32 . . . cord-023095-4dannjjm 1058 1 Eighty eighty CD cord-023095-4dannjjm 1058 2 - - HYPH cord-023095-4dannjjm 1058 3 eight eight CD cord-023095-4dannjjm 1058 4 individuals individual NNS cord-023095-4dannjjm 1058 5 participated participate VBD cord-023095-4dannjjm 1058 6 in in IN cord-023095-4dannjjm 1058 7 the the DT cord-023095-4dannjjm 1058 8 survey survey NN cord-023095-4dannjjm 1058 9 with with IN cord-023095-4dannjjm 1058 10 86 86 CD cord-023095-4dannjjm 1058 11 respondents respondent NNS cord-023095-4dannjjm 1058 12 being be VBG cord-023095-4dannjjm 1058 13 ACVIM ACVIM NNP cord-023095-4dannjjm 1058 14 diplomates diplomate NNS cord-023095-4dannjjm 1058 15 , , , cord-023095-4dannjjm 1058 16 1 1 CD cord-023095-4dannjjm 1058 17 respondent respondent NN cord-023095-4dannjjm 1058 18 was be VBD cord-023095-4dannjjm 1058 19 not not RB cord-023095-4dannjjm 1058 20 board board NN cord-023095-4dannjjm 1058 21 - - HYPH cord-023095-4dannjjm 1058 22 certified certify VBN cord-023095-4dannjjm 1058 23 and and CC cord-023095-4dannjjm 1058 24 1 1 CD cord-023095-4dannjjm 1058 25 respondent respondent NN cord-023095-4dannjjm 1058 26 was be VBD cord-023095-4dannjjm 1058 27 an an DT cord-023095-4dannjjm 1058 28 ACT ACT NNP cord-023095-4dannjjm 1058 29 diplomate diplomate NN cord-023095-4dannjjm 1058 30 . . . cord-023095-4dannjjm 1059 1 Nineteen nineteen CD cord-023095-4dannjjm 1059 2 respondents respondent NNS cord-023095-4dannjjm 1059 3 were be VBD cord-023095-4dannjjm 1059 4 diplomates diplomate NNS cord-023095-4dannjjm 1059 5 of of IN cord-023095-4dannjjm 1059 6 ACVIM ACVIM NNP cord-023095-4dannjjm 1059 7 and and CC cord-023095-4dannjjm 1059 8 an an DT cord-023095-4dannjjm 1059 9 additional additional JJ cord-023095-4dannjjm 1059 10 specialty specialty NN cord-023095-4dannjjm 1059 11 . . . cord-023095-4dannjjm 1060 1 Eighty eighty CD cord-023095-4dannjjm 1060 2 - - HYPH cord-023095-4dannjjm 1060 3 three three CD cord-023095-4dannjjm 1060 4 respondents respondent NNS cord-023095-4dannjjm 1060 5 had have VBD cord-023095-4dannjjm 1060 6 completed complete VBN cord-023095-4dannjjm 1060 7 an an DT cord-023095-4dannjjm 1060 8 ACVIM ACVIM NNP cord-023095-4dannjjm 1060 9 residency residency NN cord-023095-4dannjjm 1060 10 . . . cord-023095-4dannjjm 1061 1 The the DT cord-023095-4dannjjm 1061 2 majority majority NN cord-023095-4dannjjm 1061 3 of of IN cord-023095-4dannjjm 1061 4 respondents respondent NNS cord-023095-4dannjjm 1061 5 were be VBD cord-023095-4dannjjm 1061 6 in in IN cord-023095-4dannjjm 1061 7 academia academia NN cord-023095-4dannjjm 1061 8 ( ( -LRB- cord-023095-4dannjjm 1061 9 65 65 CD cord-023095-4dannjjm 1061 10 % % NN cord-023095-4dannjjm 1061 11 ) ) -RRB- cord-023095-4dannjjm 1061 12 with with IN cord-023095-4dannjjm 1061 13 30 30 CD cord-023095-4dannjjm 1061 14 % % NN cord-023095-4dannjjm 1061 15 being be VBG cord-023095-4dannjjm 1061 16 in in IN cord-023095-4dannjjm 1061 17 private private JJ cord-023095-4dannjjm 1061 18 practice practice NN cord-023095-4dannjjm 1061 19 . . . cord-023095-4dannjjm 1062 1 Equine equine NN cord-023095-4dannjjm 1062 2 specialists specialist NNS cord-023095-4dannjjm 1062 3 prevailed prevail VBD cord-023095-4dannjjm 1062 4 ( ( -LRB- cord-023095-4dannjjm 1062 5 53 53 CD cord-023095-4dannjjm 1062 6 % % NN cord-023095-4dannjjm 1062 7 ) ) -RRB- cord-023095-4dannjjm 1062 8 followed follow VBN cord-023095-4dannjjm 1062 9 by by IN cord-023095-4dannjjm 1062 10 mixed mixed JJ cord-023095-4dannjjm 1062 11 large large JJ cord-023095-4dannjjm 1062 12 animal animal NN cord-023095-4dannjjm 1062 13 ( ( -LRB- cord-023095-4dannjjm 1062 14 28 28 CD cord-023095-4dannjjm 1062 15 % % NN cord-023095-4dannjjm 1062 16 ) ) -RRB- cord-023095-4dannjjm 1062 17 and and CC cord-023095-4dannjjm 1062 18 then then RB cord-023095-4dannjjm 1062 19 food food NN cord-023095-4dannjjm 1062 20 animal animal NN cord-023095-4dannjjm 1062 21 only only RB cord-023095-4dannjjm 1062 22 specialists specialist NNS cord-023095-4dannjjm 1062 23 ( ( -LRB- cord-023095-4dannjjm 1062 24 13 13 CD cord-023095-4dannjjm 1062 25 % % NN cord-023095-4dannjjm 1062 26 ) ) -RRB- cord-023095-4dannjjm 1062 27 . . . cord-023095-4dannjjm 1063 1 The the DT cord-023095-4dannjjm 1063 2 distribution distribution NN cord-023095-4dannjjm 1063 3 of of IN cord-023095-4dannjjm 1063 4 years year NNS cord-023095-4dannjjm 1063 5 post post NN cord-023095-4dannjjm 1063 6 - - NN cord-023095-4dannjjm 1063 7 residency residency NN cord-023095-4dannjjm 1063 8 was be VBD cord-023095-4dannjjm 1063 9 slightly slightly RB cord-023095-4dannjjm 1063 10 skewed skewed JJ cord-023095-4dannjjm 1063 11 toward toward IN cord-023095-4dannjjm 1063 12 younger young JJR cord-023095-4dannjjm 1063 13 diplomates diplomate NNS cord-023095-4dannjjm 1063 14 , , , cord-023095-4dannjjm 1063 15 but but CC cord-023095-4dannjjm 1063 16 overall overall JJ cord-023095-4dannjjm 1063 17 there there EX cord-023095-4dannjjm 1063 18 was be VBD cord-023095-4dannjjm 1063 19 a a DT cord-023095-4dannjjm 1063 20 good good JJ cord-023095-4dannjjm 1063 21 distribution distribution NN cord-023095-4dannjjm 1063 22 of of IN cord-023095-4dannjjm 1063 23 diplomates diplomate NNS cord-023095-4dannjjm 1063 24 across across IN cord-023095-4dannjjm 1063 25 years year NNS cord-023095-4dannjjm 1063 26 of of IN cord-023095-4dannjjm 1063 27 experience experience NN cord-023095-4dannjjm 1063 28 . . . cord-023095-4dannjjm 1064 1 Most Most JJS cord-023095-4dannjjm 1064 2 respondents respondent NNS cord-023095-4dannjjm 1064 3 stated state VBD cord-023095-4dannjjm 1064 4 that that IN cord-023095-4dannjjm 1064 5 they -PRON- PRP cord-023095-4dannjjm 1064 6 did do VBD cord-023095-4dannjjm 1064 7 not not RB cord-023095-4dannjjm 1064 8 make make VB cord-023095-4dannjjm 1064 9 hiring hire VBG cord-023095-4dannjjm 1064 10 decisions decision NNS cord-023095-4dannjjm 1064 11 in in IN cord-023095-4dannjjm 1064 12 their -PRON- PRP$ cord-023095-4dannjjm 1064 13 practice practice NN cord-023095-4dannjjm 1064 14 . . . cord-023095-4dannjjm 1065 1 Competency competency NN cord-023095-4dannjjm 1065 2 in in IN cord-023095-4dannjjm 1065 3 disciplines discipline NNS cord-023095-4dannjjm 1065 4 other other JJ cord-023095-4dannjjm 1065 5 than than IN cord-023095-4dannjjm 1065 6 internal internal JJ cord-023095-4dannjjm 1065 7 medicine medicine NN cord-023095-4dannjjm 1065 8 was be VBD cord-023095-4dannjjm 1065 9 expected expect VBN cord-023095-4dannjjm 1065 10 with with IN cord-023095-4dannjjm 1065 11 ultrasonography ultrasonography NN cord-023095-4dannjjm 1065 12 and and CC cord-023095-4dannjjm 1065 13 radiology radiology NN cord-023095-4dannjjm 1065 14 being be VBG cord-023095-4dannjjm 1065 15 the the DT cord-023095-4dannjjm 1065 16 most most RBS cord-023095-4dannjjm 1065 17 desirable desirable JJ cord-023095-4dannjjm 1065 18 followed follow VBN cord-023095-4dannjjm 1065 19 by by IN cord-023095-4dannjjm 1065 20 theriogenology theriogenology NN cord-023095-4dannjjm 1065 21 and and CC cord-023095-4dannjjm 1065 22 lameness lameness NN cord-023095-4dannjjm 1065 23 . . . cord-023095-4dannjjm 1066 1 Surgical surgical JJ cord-023095-4dannjjm 1066 2 skills skill NNS cord-023095-4dannjjm 1066 3 , , , cord-023095-4dannjjm 1066 4 both both DT cord-023095-4dannjjm 1066 5 equine equine JJ cord-023095-4dannjjm 1066 6 abdominal abdominal NN cord-023095-4dannjjm 1066 7 ( ( -LRB- cord-023095-4dannjjm 1066 8 10 10 CD cord-023095-4dannjjm 1066 9 % % NN cord-023095-4dannjjm 1066 10 ) ) -RRB- cord-023095-4dannjjm 1066 11 and and CC cord-023095-4dannjjm 1066 12 food food NN cord-023095-4dannjjm 1066 13 animal animal NN cord-023095-4dannjjm 1066 14 general general JJ cord-023095-4dannjjm 1066 15 surgery surgery NN cord-023095-4dannjjm 1066 16 ( ( -LRB- cord-023095-4dannjjm 1066 17 11 11 CD cord-023095-4dannjjm 1066 18 % % NN cord-023095-4dannjjm 1066 19 ) ) -RRB- cord-023095-4dannjjm 1066 20 were be VBD cord-023095-4dannjjm 1066 21 considered consider VBN cord-023095-4dannjjm 1066 22 important important JJ cord-023095-4dannjjm 1066 23 by by IN cord-023095-4dannjjm 1066 24 some some DT cord-023095-4dannjjm 1066 25 respondents respondent NNS cord-023095-4dannjjm 1066 26 . . . cord-023095-4dannjjm 1067 1 Thirty thirty CD cord-023095-4dannjjm 1067 2 - - HYPH cord-023095-4dannjjm 1067 3 six six CD cord-023095-4dannjjm 1067 4 per per IN cord-023095-4dannjjm 1067 5 cent cent NN cord-023095-4dannjjm 1067 6 of of IN cord-023095-4dannjjm 1067 7 respondents respondent NNS cord-023095-4dannjjm 1067 8 thought think VBD cord-023095-4dannjjm 1067 9 that that IN cord-023095-4dannjjm 1067 10 a a DT cord-023095-4dannjjm 1067 11 new new JJ cord-023095-4dannjjm 1067 12 diplomate diplomate NN cord-023095-4dannjjm 1067 13 should should MD cord-023095-4dannjjm 1067 14 expect expect VB cord-023095-4dannjjm 1067 15 to to TO cord-023095-4dannjjm 1067 16 make make VB cord-023095-4dannjjm 1067 17 o o NN cord-023095-4dannjjm 1067 18 $ $ $ cord-023095-4dannjjm 1067 19 50,000 50,000 CD cord-023095-4dannjjm 1067 20 per per IN cord-023095-4dannjjm 1067 21 annum annum NN cord-023095-4dannjjm 1067 22 , , , cord-023095-4dannjjm 1067 23 while while IN cord-023095-4dannjjm 1067 24 only only RB cord-023095-4dannjjm 1067 25 13 13 CD cord-023095-4dannjjm 1067 26 % % NN cord-023095-4dannjjm 1067 27 of of IN cord-023095-4dannjjm 1067 28 respondents respondent NNS cord-023095-4dannjjm 1067 29 thought think VBD cord-023095-4dannjjm 1067 30 that that IN cord-023095-4dannjjm 1067 31 a a DT cord-023095-4dannjjm 1067 32 new new JJ cord-023095-4dannjjm 1067 33 diplomate diplomate NN cord-023095-4dannjjm 1067 34 should should MD cord-023095-4dannjjm 1067 35 expect expect VB cord-023095-4dannjjm 1067 36 to to TO cord-023095-4dannjjm 1067 37 make make VB cord-023095-4dannjjm 1067 38 ! ! . cord-023095-4dannjjm 1068 1 $ $ $ cord-023095-4dannjjm 1068 2 90,000 90,000 CD cord-023095-4dannjjm 1068 3 per per IN cord-023095-4dannjjm 1068 4 annum annum NN cord-023095-4dannjjm 1068 5 . . . cord-023095-4dannjjm 1069 1 Not not RB cord-023095-4dannjjm 1069 2 all all DT cord-023095-4dannjjm 1069 3 respondents respondent NNS cord-023095-4dannjjm 1069 4 answered answer VBD cord-023095-4dannjjm 1069 5 questions question NNS cord-023095-4dannjjm 1069 6 on on IN cord-023095-4dannjjm 1069 7 all all DT cord-023095-4dannjjm 1069 8 skills skill NNS cord-023095-4dannjjm 1069 9 or or CC cord-023095-4dannjjm 1069 10 concepts concept NNS cord-023095-4dannjjm 1069 11 . . . cord-023095-4dannjjm 1070 1 The the DT cord-023095-4dannjjm 1070 2 mean mean JJ cord-023095-4dannjjm 1070 3 number number NN cord-023095-4dannjjm 1070 4 of of IN cord-023095-4dannjjm 1070 5 skills skill NNS cord-023095-4dannjjm 1070 6 or or CC cord-023095-4dannjjm 1070 7 concepts concept NNS cord-023095-4dannjjm 1070 8 evaluated evaluate VBN cord-023095-4dannjjm 1070 9 was be VBD cord-023095-4dannjjm 1070 10 86 86 CD cord-023095-4dannjjm 1071 1 ( ( -LRB- cord-023095-4dannjjm 1071 2 SD SD NNP cord-023095-4dannjjm 1071 3 5 5 CD cord-023095-4dannjjm 1071 4 75 75 CD cord-023095-4dannjjm 1071 5 ) ) -RRB- cord-023095-4dannjjm 1071 6 with with IN cord-023095-4dannjjm 1071 7 only only RB cord-023095-4dannjjm 1071 8 18 18 CD cord-023095-4dannjjm 1071 9 respondents respondent NNS cord-023095-4dannjjm 1071 10 answering answer VBG cord-023095-4dannjjm 1071 11 all all DT cord-023095-4dannjjm 1071 12 189 189 CD cord-023095-4dannjjm 1071 13 . . . cord-023095-4dannjjm 1072 1 All all DT cord-023095-4dannjjm 1072 2 skills skill NNS cord-023095-4dannjjm 1072 3 or or CC cord-023095-4dannjjm 1072 4 concepts concept NNS cord-023095-4dannjjm 1072 5 evaluated evaluate VBN cord-023095-4dannjjm 1072 6 were be VBD cord-023095-4dannjjm 1072 7 found find VBN cord-023095-4dannjjm 1072 8 to to TO cord-023095-4dannjjm 1072 9 be be VB cord-023095-4dannjjm 1072 10 at at IN cord-023095-4dannjjm 1072 11 least least JJS cord-023095-4dannjjm 1072 12 somewhat somewhat RB cord-023095-4dannjjm 1072 13 important important JJ cord-023095-4dannjjm 1072 14 , , , cord-023095-4dannjjm 1072 15 were be VBD cord-023095-4dannjjm 1072 16 estimated estimate VBN cord-023095-4dannjjm 1072 17 to to TO cord-023095-4dannjjm 1072 18 be be VB cord-023095-4dannjjm 1072 19 used use VBN cord-023095-4dannjjm 1072 20 at at IN cord-023095-4dannjjm 1072 21 least least JJS cord-023095-4dannjjm 1072 22 occasionally occasionally RB cord-023095-4dannjjm 1072 23 , , , cord-023095-4dannjjm 1072 24 were be VBD cord-023095-4dannjjm 1072 25 recommended recommend VBN cord-023095-4dannjjm 1072 26 for for IN cord-023095-4dannjjm 1072 27 inclusion inclusion NN cord-023095-4dannjjm 1072 28 in in IN cord-023095-4dannjjm 1072 29 training training NN cord-023095-4dannjjm 1072 30 programs program NNS cord-023095-4dannjjm 1072 31 as as IN cord-023095-4dannjjm 1072 32 core core NN cord-023095-4dannjjm 1072 33 or or CC cord-023095-4dannjjm 1072 34 elective elective JJ cord-023095-4dannjjm 1072 35 , , , cord-023095-4dannjjm 1072 36 and and CC cord-023095-4dannjjm 1072 37 some some DT cord-023095-4dannjjm 1072 38 level level NN cord-023095-4dannjjm 1072 39 of of IN cord-023095-4dannjjm 1072 40 knowledge knowledge NN cord-023095-4dannjjm 1072 41 was be VBD cord-023095-4dannjjm 1072 42 expected expect VBN cord-023095-4dannjjm 1072 43 . . . cord-023095-4dannjjm 1073 1 At at IN cord-023095-4dannjjm 1073 2 least least JJS cord-023095-4dannjjm 1073 3 some some DT cord-023095-4dannjjm 1073 4 of of IN cord-023095-4dannjjm 1073 5 the the DT cord-023095-4dannjjm 1073 6 respondents respondent NNS cord-023095-4dannjjm 1073 7 were be VBD cord-023095-4dannjjm 1073 8 taught teach VBN cord-023095-4dannjjm 1073 9 each each DT cord-023095-4dannjjm 1073 10 of of IN cord-023095-4dannjjm 1073 11 the the DT cord-023095-4dannjjm 1073 12 skills skill NNS cord-023095-4dannjjm 1073 13 or or CC cord-023095-4dannjjm 1073 14 concepts concept NNS cord-023095-4dannjjm 1073 15 during during IN cord-023095-4dannjjm 1073 16 their -PRON- PRP$ cord-023095-4dannjjm 1073 17 residency residency NN cord-023095-4dannjjm 1073 18 , , , cord-023095-4dannjjm 1073 19 practiced practice VBD cord-023095-4dannjjm 1073 20 the the DT cord-023095-4dannjjm 1073 21 skill skill NN cord-023095-4dannjjm 1073 22 or or CC cord-023095-4dannjjm 1073 23 concept concept NN cord-023095-4dannjjm 1073 24 at at IN cord-023095-4dannjjm 1073 25 least least JJS cord-023095-4dannjjm 1073 26 occasionally occasionally RB cord-023095-4dannjjm 1073 27 during during IN cord-023095-4dannjjm 1073 28 their -PRON- PRP$ cord-023095-4dannjjm 1073 29 residency residency NN cord-023095-4dannjjm 1073 30 , , , cord-023095-4dannjjm 1073 31 and and CC cord-023095-4dannjjm 1073 32 some some DT cord-023095-4dannjjm 1073 33 degree degree NN cord-023095-4dannjjm 1073 34 of of IN cord-023095-4dannjjm 1073 35 competency competency NN cord-023095-4dannjjm 1073 36 was be VBD cord-023095-4dannjjm 1073 37 expected expect VBN cord-023095-4dannjjm 1073 38 at at IN cord-023095-4dannjjm 1073 39 the the DT cord-023095-4dannjjm 1073 40 time time NN cord-023095-4dannjjm 1073 41 of of IN cord-023095-4dannjjm 1073 42 completion completion NN cord-023095-4dannjjm 1073 43 of of IN cord-023095-4dannjjm 1073 44 their -PRON- PRP$ cord-023095-4dannjjm 1073 45 residency residency NN cord-023095-4dannjjm 1073 46 . . . cord-023095-4dannjjm 1074 1 These these DT cord-023095-4dannjjm 1074 2 data datum NNS cord-023095-4dannjjm 1074 3 will will MD cord-023095-4dannjjm 1074 4 provide provide VB cord-023095-4dannjjm 1074 5 a a DT cord-023095-4dannjjm 1074 6 framework framework NN cord-023095-4dannjjm 1074 7 for for IN cord-023095-4dannjjm 1074 8 designing design VBG cord-023095-4dannjjm 1074 9 future future JJ cord-023095-4dannjjm 1074 10 LAIM LAIM NNP cord-023095-4dannjjm 1074 11 residency residency NN cord-023095-4dannjjm 1074 12 programs program NNS cord-023095-4dannjjm 1074 13 . . . cord-023095-4dannjjm 1075 1 ABSTRACT ABSTRACT NNP cord-023095-4dannjjm 1076 1 This this DT cord-023095-4dannjjm 1076 2 study study NN cord-023095-4dannjjm 1076 3 evaluated evaluate VBD cord-023095-4dannjjm 1076 4 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 1076 5 and and CC cord-023095-4dannjjm 1076 6 clinical clinical JJ cord-023095-4dannjjm 1076 7 safety safety NN cord-023095-4dannjjm 1076 8 of of IN cord-023095-4dannjjm 1076 9 an an DT cord-023095-4dannjjm 1076 10 oral oral JJ cord-023095-4dannjjm 1076 11 paste paste NN cord-023095-4dannjjm 1076 12 formulation formulation NN cord-023095-4dannjjm 1076 13 of of IN cord-023095-4dannjjm 1076 14 a a DT cord-023095-4dannjjm 1076 15 commercially commercially RB cord-023095-4dannjjm 1076 16 available available JJ cord-023095-4dannjjm 1076 17 COX1-sparing cox1-spare VBG cord-023095-4dannjjm 1076 18 NSAID NSAID NNP cord-023095-4dannjjm 1076 19 in in IN cord-023095-4dannjjm 1076 20 clinically clinically RB cord-023095-4dannjjm 1076 21 healthy healthy JJ cord-023095-4dannjjm 1076 22 pony pony NN cord-023095-4dannjjm 1076 23 foals foal NNS cord-023095-4dannjjm 1076 24 in in IN cord-023095-4dannjjm 1076 25 a a DT cord-023095-4dannjjm 1076 26 randomized randomized JJ cord-023095-4dannjjm 1076 27 controlled control VBN cord-023095-4dannjjm 1076 28 clinical clinical JJ cord-023095-4dannjjm 1076 29 trial trial NN cord-023095-4dannjjm 1076 30 . . . cord-023095-4dannjjm 1077 1 Values value NNS cord-023095-4dannjjm 1077 2 for for IN cord-023095-4dannjjm 1077 3 complete complete JJ cord-023095-4dannjjm 1077 4 blood blood NN cord-023095-4dannjjm 1077 5 count count NN cord-023095-4dannjjm 1077 6 , , , cord-023095-4dannjjm 1077 7 serum serum NN cord-023095-4dannjjm 1077 8 chemistry chemistry NN cord-023095-4dannjjm 1077 9 profile profile NN cord-023095-4dannjjm 1077 10 , , , cord-023095-4dannjjm 1077 11 urinalysis urinalysis NN cord-023095-4dannjjm 1077 12 , , , cord-023095-4dannjjm 1077 13 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 1077 14 assay assay NN cord-023095-4dannjjm 1077 15 , , , cord-023095-4dannjjm 1077 16 and and CC cord-023095-4dannjjm 1077 17 gastric gastric JJ cord-023095-4dannjjm 1077 18 endoscopy endoscopy NN cord-023095-4dannjjm 1077 19 were be VBD cord-023095-4dannjjm 1077 20 evaluated evaluate VBN cord-023095-4dannjjm 1077 21 in in IN cord-023095-4dannjjm 1077 22 eighteen eighteen CD cord-023095-4dannjjm 1077 23 Shetland Shetland NNP cord-023095-4dannjjm 1077 24 pony pony NN cord-023095-4dannjjm 1077 25 foals foal NNS cord-023095-4dannjjm 1077 26 treated treat VBN cord-023095-4dannjjm 1077 27 with with IN cord-023095-4dannjjm 1077 28 firocoxib firocoxib NNS cord-023095-4dannjjm 1077 29 ( ( -LRB- cord-023095-4dannjjm 1077 30 0.1 0.1 CD cord-023095-4dannjjm 1077 31 mg mg NNP cord-023095-4dannjjm 1077 32 / / SYM cord-023095-4dannjjm 1077 33 kg kg NNP cord-023095-4dannjjm 1077 34 , , , cord-023095-4dannjjm 1077 35 PO PO NNP cord-023095-4dannjjm 1077 36 , , , cord-023095-4dannjjm 1077 37 q q NNP cord-023095-4dannjjm 1077 38 24 24 CD cord-023095-4dannjjm 1077 39 h h NNP cord-023095-4dannjjm 1077 40 ) ) -RRB- cord-023095-4dannjjm 1077 41 or or CC cord-023095-4dannjjm 1077 42 placebo placebo NN cord-023095-4dannjjm 1077 43 for for IN cord-023095-4dannjjm 1077 44 14 14 CD cord-023095-4dannjjm 1077 45 days day NNS cord-023095-4dannjjm 1077 46 . . . cord-023095-4dannjjm 1078 1 Foals foal NNS cord-023095-4dannjjm 1078 2 were be VBD cord-023095-4dannjjm 1078 3 divided divide VBN cord-023095-4dannjjm 1078 4 into into IN cord-023095-4dannjjm 1078 5 3 3 CD cord-023095-4dannjjm 1078 6 treatment treatment NN cord-023095-4dannjjm 1078 7 groups group NNS cord-023095-4dannjjm 1078 8 . . . cord-023095-4dannjjm 1079 1 Group group NN cord-023095-4dannjjm 1079 2 1 1 CD cord-023095-4dannjjm 1079 3 and and CC cord-023095-4dannjjm 1079 4 2 2 CD cord-023095-4dannjjm 1079 5 foals foal NNS cord-023095-4dannjjm 1079 6 received receive VBD cord-023095-4dannjjm 1079 7 firocoxib firocoxib NNS cord-023095-4dannjjm 1079 8 while while IN cord-023095-4dannjjm 1079 9 a a DT cord-023095-4dannjjm 1079 10 3rd 3rd JJ cord-023095-4dannjjm 1079 11 group group NN cord-023095-4dannjjm 1079 12 was be VBD cord-023095-4dannjjm 1079 13 administered administer VBN cord-023095-4dannjjm 1079 14 an an DT cord-023095-4dannjjm 1079 15 oral oral JJ cord-023095-4dannjjm 1079 16 placebo placebo NN cord-023095-4dannjjm 1079 17 . . . cord-023095-4dannjjm 1080 1 Gastric gastric JJ cord-023095-4dannjjm 1080 2 endoscopy endoscopy NN cord-023095-4dannjjm 1080 3 was be VBD cord-023095-4dannjjm 1080 4 performed perform VBN cord-023095-4dannjjm 1080 5 on on IN cord-023095-4dannjjm 1080 6 group group NN cord-023095-4dannjjm 1080 7 1 1 CD cord-023095-4dannjjm 1080 8 and and CC cord-023095-4dannjjm 1080 9 3 3 CD cord-023095-4dannjjm 1080 10 foals foal NNS cord-023095-4dannjjm 1080 11 prior prior RB cord-023095-4dannjjm 1080 12 to to IN cord-023095-4dannjjm 1080 13 treatment treatment NN cord-023095-4dannjjm 1080 14 and and CC cord-023095-4dannjjm 1080 15 on on IN cord-023095-4dannjjm 1080 16 days day NNS cord-023095-4dannjjm 1080 17 7 7 CD cord-023095-4dannjjm 1080 18 and and CC cord-023095-4dannjjm 1080 19 14 14 CD cord-023095-4dannjjm 1080 20 to to TO cord-023095-4dannjjm 1080 21 monitor monitor VB cord-023095-4dannjjm 1080 22 for for IN cord-023095-4dannjjm 1080 23 the the DT cord-023095-4dannjjm 1080 24 presence presence NN cord-023095-4dannjjm 1080 25 of of IN cord-023095-4dannjjm 1080 26 gastric gastric JJ cord-023095-4dannjjm 1080 27 ulcers ulcer NNS cord-023095-4dannjjm 1080 28 . . . cord-023095-4dannjjm 1081 1 Group group NN cord-023095-4dannjjm 1081 2 2 2 CD cord-023095-4dannjjm 1081 3 and and CC cord-023095-4dannjjm 1081 4 3 3 CD cord-023095-4dannjjm 1081 5 foals foal NNS cord-023095-4dannjjm 1081 6 had have VBD cord-023095-4dannjjm 1081 7 blood blood NN cord-023095-4dannjjm 1081 8 and and CC cord-023095-4dannjjm 1081 9 urine urine NN cord-023095-4dannjjm 1081 10 samples sample NNS cord-023095-4dannjjm 1081 11 taken take VBN cord-023095-4dannjjm 1081 12 sequentially sequentially RB cord-023095-4dannjjm 1081 13 for for IN cord-023095-4dannjjm 1081 14 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 1081 15 analysis analysis NN cord-023095-4dannjjm 1081 16 , , , cord-023095-4dannjjm 1081 17 CBC CBC NNP cord-023095-4dannjjm 1081 18 , , , cord-023095-4dannjjm 1081 19 serum serum NN cord-023095-4dannjjm 1081 20 chemistry chemistry NN cord-023095-4dannjjm 1081 21 evaluation evaluation NN cord-023095-4dannjjm 1081 22 , , , cord-023095-4dannjjm 1081 23 and and CC cord-023095-4dannjjm 1081 24 urinalysis urinalysis NN cord-023095-4dannjjm 1081 25 . . . cord-023095-4dannjjm 1082 1 Physical physical JJ cord-023095-4dannjjm 1082 2 examinations examination NNS cord-023095-4dannjjm 1082 3 were be VBD cord-023095-4dannjjm 1082 4 performed perform VBN cord-023095-4dannjjm 1082 5 prior prior RB cord-023095-4dannjjm 1082 6 to to IN cord-023095-4dannjjm 1082 7 treatment treatment NN cord-023095-4dannjjm 1082 8 and and CC cord-023095-4dannjjm 1082 9 daily daily NN cord-023095-4dannjjm 1082 10 for for IN cord-023095-4dannjjm 1082 11 17 17 CD cord-023095-4dannjjm 1082 12 days day NNS cord-023095-4dannjjm 1082 13 . . . cord-023095-4dannjjm 1083 1 Data datum NNS cord-023095-4dannjjm 1083 2 were be VBD cord-023095-4dannjjm 1083 3 analyzed analyze VBN cord-023095-4dannjjm 1083 4 using use VBG cord-023095-4dannjjm 1083 5 anova anova NNP cord-023095-4dannjjm 1083 6 and and CC cord-023095-4dannjjm 1083 7 paired pair VBD cord-023095-4dannjjm 1083 8 t t NN cord-023095-4dannjjm 1083 9 - - HYPH cord-023095-4dannjjm 1083 10 tests test NNS cord-023095-4dannjjm 1083 11 ( ( -LRB- cord-023095-4dannjjm 1083 12 P p NN cord-023095-4dannjjm 1083 13 o o NN cord-023095-4dannjjm 1083 14 0.05 0.05 CD cord-023095-4dannjjm 1083 15 ) ) -RRB- cord-023095-4dannjjm 1083 16 . . . cord-023095-4dannjjm 1084 1 None none NN cord-023095-4dannjjm 1084 2 of of IN cord-023095-4dannjjm 1084 3 the the DT cord-023095-4dannjjm 1084 4 foals foal NNS cord-023095-4dannjjm 1084 5 presented present VBD cord-023095-4dannjjm 1084 6 adverse adverse JJ cord-023095-4dannjjm 1084 7 clinical clinical JJ cord-023095-4dannjjm 1084 8 effects effect NNS cord-023095-4dannjjm 1084 9 . . . cord-023095-4dannjjm 1085 1 There there EX cord-023095-4dannjjm 1085 2 were be VBD cord-023095-4dannjjm 1085 3 no no DT cord-023095-4dannjjm 1085 4 significant significant JJ cord-023095-4dannjjm 1085 5 changes change NNS cord-023095-4dannjjm 1085 6 in in IN cord-023095-4dannjjm 1085 7 CBC CBC NNP cord-023095-4dannjjm 1085 8 , , , cord-023095-4dannjjm 1085 9 biochemical biochemical JJ cord-023095-4dannjjm 1085 10 profiles profile NNS cord-023095-4dannjjm 1085 11 within within IN cord-023095-4dannjjm 1085 12 groups group NNS cord-023095-4dannjjm 1085 13 , , , cord-023095-4dannjjm 1085 14 or or CC cord-023095-4dannjjm 1085 15 differences difference NNS cord-023095-4dannjjm 1085 16 between between IN cord-023095-4dannjjm 1085 17 groups group NNS cord-023095-4dannjjm 1085 18 . . . cord-023095-4dannjjm 1086 1 Pretreatment pretreatment JJ cord-023095-4dannjjm 1086 2 gastric gastric JJ cord-023095-4dannjjm 1086 3 endoscopy endoscopy NN cord-023095-4dannjjm 1086 4 scores score NNS cord-023095-4dannjjm 1086 5 were be VBD cord-023095-4dannjjm 1086 6 not not RB cord-023095-4dannjjm 1086 7 significantly significantly RB cord-023095-4dannjjm 1086 8 different different JJ cord-023095-4dannjjm 1086 9 from from IN cord-023095-4dannjjm 1086 10 evaluations evaluation NNS cord-023095-4dannjjm 1086 11 at at IN cord-023095-4dannjjm 1086 12 7 7 CD cord-023095-4dannjjm 1086 13 and and CC cord-023095-4dannjjm 1086 14 14 14 CD cord-023095-4dannjjm 1086 15 days day NNS cord-023095-4dannjjm 1086 16 . . . cord-023095-4dannjjm 1087 1 Firocoxib Firocoxib NNP cord-023095-4dannjjm 1087 2 was be VBD cord-023095-4dannjjm 1087 3 quickly quickly RB cord-023095-4dannjjm 1087 4 absorbed absorb VBN cord-023095-4dannjjm 1087 5 with with IN cord-023095-4dannjjm 1087 6 an an DT cord-023095-4dannjjm 1087 7 observed observed JJ cord-023095-4dannjjm 1087 8 maximum maximum JJ cord-023095-4dannjjm 1087 9 concentration concentration NN cord-023095-4dannjjm 1087 10 at at IN cord-023095-4dannjjm 1087 11 2 2 CD cord-023095-4dannjjm 1087 12 hr hr NN cord-023095-4dannjjm 1087 13 , , , cord-023095-4dannjjm 1087 14 the the DT cord-023095-4dannjjm 1087 15 first first JJ cord-023095-4dannjjm 1087 16 sampling sampling NN cord-023095-4dannjjm 1087 17 interval interval NN cord-023095-4dannjjm 1087 18 , , , cord-023095-4dannjjm 1087 19 for for IN cord-023095-4dannjjm 1087 20 the the DT cord-023095-4dannjjm 1087 21 majority majority NN cord-023095-4dannjjm 1087 22 of of IN cord-023095-4dannjjm 1087 23 animals animal NNS cord-023095-4dannjjm 1087 24 . . . cord-023095-4dannjjm 1088 1 Firocoxib Firocoxib NNP cord-023095-4dannjjm 1088 2 plasma plasma NN cord-023095-4dannjjm 1088 3 concentrations concentration NNS cord-023095-4dannjjm 1088 4 decreased decrease VBD cord-023095-4dannjjm 1088 5 in in IN cord-023095-4dannjjm 1088 6 a a DT cord-023095-4dannjjm 1088 7 log log NN cord-023095-4dannjjm 1088 8 - - HYPH cord-023095-4dannjjm 1088 9 linear linear JJ cord-023095-4dannjjm 1088 10 manner manner NN cord-023095-4dannjjm 1088 11 after after IN cord-023095-4dannjjm 1088 12 reaching reach VBG cord-023095-4dannjjm 1088 13 the the DT cord-023095-4dannjjm 1088 14 maximum maximum JJ cord-023095-4dannjjm 1088 15 concentration concentration NN cord-023095-4dannjjm 1088 16 and and CC cord-023095-4dannjjm 1088 17 steady steady JJ cord-023095-4dannjjm 1088 18 state state NN cord-023095-4dannjjm 1088 19 concentrations concentration NNS cord-023095-4dannjjm 1088 20 were be VBD cord-023095-4dannjjm 1088 21 achieved achieve VBN cord-023095-4dannjjm 1088 22 by by IN cord-023095-4dannjjm 1088 23 the the DT cord-023095-4dannjjm 1088 24 7th 7th JJ cord-023095-4dannjjm 1088 25 dose dose NN cord-023095-4dannjjm 1088 26 . . . cord-023095-4dannjjm 1089 1 Based base VBN cord-023095-4dannjjm 1089 2 on on IN cord-023095-4dannjjm 1089 3 the the DT cord-023095-4dannjjm 1089 4 sampling sampling NN cord-023095-4dannjjm 1089 5 times time NNS cord-023095-4dannjjm 1089 6 after after IN cord-023095-4dannjjm 1089 7 the the DT cord-023095-4dannjjm 1089 8 final final JJ cord-023095-4dannjjm 1089 9 and and CC cord-023095-4dannjjm 1089 10 14th 14th JJ cord-023095-4dannjjm 1089 11 dose dose NN cord-023095-4dannjjm 1089 12 , , , cord-023095-4dannjjm 1089 13 an an DT cord-023095-4dannjjm 1089 14 average average JJ cord-023095-4dannjjm 1089 15 half half JJ cord-023095-4dannjjm 1089 16 life life NN cord-023095-4dannjjm 1089 17 of of IN cord-023095-4dannjjm 1089 18 1.3 1.3 CD cord-023095-4dannjjm 1089 19 days day NNS cord-023095-4dannjjm 1089 20 was be VBD cord-023095-4dannjjm 1089 21 estimated estimate VBN cord-023095-4dannjjm 1089 22 . . . cord-023095-4dannjjm 1090 1 Administration Administration NNP cord-023095-4dannjjm 1090 2 of of IN cord-023095-4dannjjm 1090 3 firocoxib firocoxib NNP cord-023095-4dannjjm 1090 4 did do VBD cord-023095-4dannjjm 1090 5 not not RB cord-023095-4dannjjm 1090 6 cause cause VB cord-023095-4dannjjm 1090 7 any any DT cord-023095-4dannjjm 1090 8 adverse adverse JJ cord-023095-4dannjjm 1090 9 effects effect NNS cord-023095-4dannjjm 1090 10 on on IN cord-023095-4dannjjm 1090 11 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1090 12 , , , cord-023095-4dannjjm 1090 13 or or CC cord-023095-4dannjjm 1090 14 hematological hematological JJ cord-023095-4dannjjm 1090 15 or or CC cord-023095-4dannjjm 1090 16 serum serum JJ cord-023095-4dannjjm 1090 17 biochemical biochemical JJ cord-023095-4dannjjm 1090 18 variables variable NNS cord-023095-4dannjjm 1090 19 , , , cord-023095-4dannjjm 1090 20 appears appear VBZ cord-023095-4dannjjm 1090 21 to to TO cord-023095-4dannjjm 1090 22 have have VB cord-023095-4dannjjm 1090 23 been be VBN cord-023095-4dannjjm 1090 24 well well RB cord-023095-4dannjjm 1090 25 tolerated tolerate VBN cord-023095-4dannjjm 1090 26 , , , cord-023095-4dannjjm 1090 27 and and CC cord-023095-4dannjjm 1090 28 follows follow VBZ cord-023095-4dannjjm 1090 29 a a DT cord-023095-4dannjjm 1090 30 predictable predictable JJ cord-023095-4dannjjm 1090 31 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 1090 32 pattern pattern NN cord-023095-4dannjjm 1090 33 in in IN cord-023095-4dannjjm 1090 34 4 4 CD cord-023095-4dannjjm 1090 35 - - SYM cord-023095-4dannjjm 1090 36 6 6 CD cord-023095-4dannjjm 1090 37 week week NN cord-023095-4dannjjm 1090 38 old old JJ cord-023095-4dannjjm 1090 39 foals foal NNS cord-023095-4dannjjm 1090 40 . . . cord-023095-4dannjjm 1091 1 Equine equine JJ cord-023095-4dannjjm 1091 2 herpesvirus herpesvirus NN cord-023095-4dannjjm 1091 3 1 1 CD cord-023095-4dannjjm 1091 4 ( ( -LRB- cord-023095-4dannjjm 1091 5 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1091 6 ) ) -RRB- cord-023095-4dannjjm 1091 7 is be VBZ cord-023095-4dannjjm 1091 8 highly highly RB cord-023095-4dannjjm 1091 9 prevalent prevalent JJ cord-023095-4dannjjm 1091 10 in in IN cord-023095-4dannjjm 1091 11 most most JJS cord-023095-4dannjjm 1091 12 horse horse NN cord-023095-4dannjjm 1091 13 populations population NNS cord-023095-4dannjjm 1091 14 . . . cord-023095-4dannjjm 1092 1 Horses horse NNS cord-023095-4dannjjm 1092 2 are be VBP cord-023095-4dannjjm 1092 3 routinely routinely RB cord-023095-4dannjjm 1092 4 vaccinated vaccinate VBN cord-023095-4dannjjm 1092 5 against against IN cord-023095-4dannjjm 1092 6 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1092 7 , , , cord-023095-4dannjjm 1092 8 and and CC cord-023095-4dannjjm 1092 9 neutralizing neutralize VBG cord-023095-4dannjjm 1092 10 antibodies antibody NNS cord-023095-4dannjjm 1092 11 have have VBP cord-023095-4dannjjm 1092 12 helped help VBN cord-023095-4dannjjm 1092 13 to to TO cord-023095-4dannjjm 1092 14 prevent prevent VB cord-023095-4dannjjm 1092 15 disease disease NN cord-023095-4dannjjm 1092 16 . . . cord-023095-4dannjjm 1093 1 However however RB cord-023095-4dannjjm 1093 2 , , , cord-023095-4dannjjm 1093 3 the the DT cord-023095-4dannjjm 1093 4 USDA USDA NNP cord-023095-4dannjjm 1093 5 has have VBZ cord-023095-4dannjjm 1093 6 recently recently RB cord-023095-4dannjjm 1093 7 classified classify VBN cord-023095-4dannjjm 1093 8 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1093 9 myeloencephalopathy myeloencephalopathy . cord-023095-4dannjjm 1093 10 ( ( -LRB- cord-023095-4dannjjm 1093 11 EHM ehm UH cord-023095-4dannjjm 1093 12 ) ) -RRB- cord-023095-4dannjjm 1093 13 as as IN cord-023095-4dannjjm 1093 14 an an DT cord-023095-4dannjjm 1093 15 emerging emerge VBG cord-023095-4dannjjm 1093 16 disease disease NN cord-023095-4dannjjm 1093 17 , , , cord-023095-4dannjjm 1093 18 in in IN cord-023095-4dannjjm 1093 19 response response NN cord-023095-4dannjjm 1093 20 to to IN cord-023095-4dannjjm 1093 21 the the DT cord-023095-4dannjjm 1093 22 apparent apparent JJ cord-023095-4dannjjm 1093 23 increase increase NN cord-023095-4dannjjm 1093 24 in in IN cord-023095-4dannjjm 1093 25 incidence incidence NN cord-023095-4dannjjm 1093 26 , , , cord-023095-4dannjjm 1093 27 morbidity morbidity NN cord-023095-4dannjjm 1093 28 , , , cord-023095-4dannjjm 1093 29 and and CC cord-023095-4dannjjm 1093 30 mortality mortality NN cord-023095-4dannjjm 1093 31 of of IN cord-023095-4dannjjm 1093 32 EHM EHM NNP cord-023095-4dannjjm 1093 33 that that WDT cord-023095-4dannjjm 1093 34 suggests suggest VBZ cord-023095-4dannjjm 1093 35 a a DT cord-023095-4dannjjm 1093 36 change change NN cord-023095-4dannjjm 1093 37 in in IN cord-023095-4dannjjm 1093 38 virulence virulence NN cord-023095-4dannjjm 1093 39 of of IN cord-023095-4dannjjm 1093 40 the the DT cord-023095-4dannjjm 1093 41 virus virus NN cord-023095-4dannjjm 1093 42 . . . cord-023095-4dannjjm 1094 1 It -PRON- PRP cord-023095-4dannjjm 1094 2 has have VBZ cord-023095-4dannjjm 1094 3 been be VBN cord-023095-4dannjjm 1094 4 reported report VBN cord-023095-4dannjjm 1094 5 that that IN cord-023095-4dannjjm 1094 6 cellular cellular JJ cord-023095-4dannjjm 1094 7 immune immune JJ cord-023095-4dannjjm 1094 8 mechanisms mechanism NNS cord-023095-4dannjjm 1094 9 , , , cord-023095-4dannjjm 1094 10 in in IN cord-023095-4dannjjm 1094 11 particular particular JJ cord-023095-4dannjjm 1094 12 cytotoxic cytotoxic JJ cord-023095-4dannjjm 1094 13 T t NN cord-023095-4dannjjm 1094 14 - - HYPH cord-023095-4dannjjm 1094 15 cells cell NNS cord-023095-4dannjjm 1094 16 ( ( -LRB- cord-023095-4dannjjm 1094 17 CTLs CTLs NNP cord-023095-4dannjjm 1094 18 ) ) -RRB- cord-023095-4dannjjm 1094 19 , , , cord-023095-4dannjjm 1094 20 are be VBP cord-023095-4dannjjm 1094 21 important important JJ cord-023095-4dannjjm 1094 22 in in IN cord-023095-4dannjjm 1094 23 controlling control VBG cord-023095-4dannjjm 1094 24 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1094 25 viremia viremia NN cord-023095-4dannjjm 1094 26 . . . cord-023095-4dannjjm 1095 1 Interferon interferon NN cord-023095-4dannjjm 1095 2 - - HYPH cord-023095-4dannjjm 1095 3 alpha alpha NN cord-023095-4dannjjm 1095 4 ( ( -LRB- cord-023095-4dannjjm 1095 5 IFN IFN NNP cord-023095-4dannjjm 1095 6 - - HYPH cord-023095-4dannjjm 1095 7 a a LS cord-023095-4dannjjm 1095 8 ) ) -RRB- cord-023095-4dannjjm 1095 9 has have VBZ cord-023095-4dannjjm 1095 10 a a DT cord-023095-4dannjjm 1095 11 key key JJ cord-023095-4dannjjm 1095 12 function function NN cord-023095-4dannjjm 1095 13 in in IN cord-023095-4dannjjm 1095 14 innate innate JJ cord-023095-4dannjjm 1095 15 immune immune JJ cord-023095-4dannjjm 1095 16 regulation regulation NN cord-023095-4dannjjm 1095 17 by by IN cord-023095-4dannjjm 1095 18 inducing induce VBG cord-023095-4dannjjm 1095 19 the the DT cord-023095-4dannjjm 1095 20 differentiation differentiation NN cord-023095-4dannjjm 1095 21 and and CC cord-023095-4dannjjm 1095 22 maturation maturation NN cord-023095-4dannjjm 1095 23 of of IN cord-023095-4dannjjm 1095 24 CTLs ctl NNS cord-023095-4dannjjm 1095 25 . . . cord-023095-4dannjjm 1096 1 Here here RB cord-023095-4dannjjm 1096 2 , , , cord-023095-4dannjjm 1096 3 we -PRON- PRP cord-023095-4dannjjm 1096 4 investigated investigate VBD cord-023095-4dannjjm 1096 5 the the DT cord-023095-4dannjjm 1096 6 influence influence NN cord-023095-4dannjjm 1096 7 of of IN cord-023095-4dannjjm 1096 8 abortogenic abortogenic NNP cord-023095-4dannjjm 1096 9 ( ( -LRB- cord-023095-4dannjjm 1096 10 RacL11 RacL11 NNP cord-023095-4dannjjm 1096 11 , , , cord-023095-4dannjjm 1096 12 NY03 NY03 NNP cord-023095-4dannjjm 1096 13 ) ) -RRB- cord-023095-4dannjjm 1096 14 and and CC cord-023095-4dannjjm 1096 15 neuropathogenic neuropathogenic NNP cord-023095-4dannjjm 1096 16 ( ( -LRB- cord-023095-4dannjjm 1096 17 Ab4 ab4 NN cord-023095-4dannjjm 1096 18 ) ) -RRB- cord-023095-4dannjjm 1097 1 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1097 2 virus virus NN cord-023095-4dannjjm 1097 3 strains strain VBZ cord-023095-4dannjjm 1097 4 on on IN cord-023095-4dannjjm 1097 5 IFN IFN NNP cord-023095-4dannjjm 1097 6 - - HYPH cord-023095-4dannjjm 1097 7 a a NNP cord-023095-4dannjjm 1097 8 , , , cord-023095-4dannjjm 1097 9 IL-4 IL-4 NNP cord-023095-4dannjjm 1097 10 and and CC cord-023095-4dannjjm 1097 11 IL-10 IL-10 NNP cord-023095-4dannjjm 1097 12 secretion secretion NN cord-023095-4dannjjm 1097 13 in in IN cord-023095-4dannjjm 1097 14 equine equine JJ cord-023095-4dannjjm 1097 15 PBMC PBMC NNS cord-023095-4dannjjm 1097 16 . . . cord-023095-4dannjjm 1098 1 Equine Equine NNP cord-023095-4dannjjm 1098 2 PBMC PBMC NNP cord-023095-4dannjjm 1098 3 were be VBD cord-023095-4dannjjm 1098 4 infected infect VBN cord-023095-4dannjjm 1098 5 with with IN cord-023095-4dannjjm 1098 6 RacL11 racl11 NN cord-023095-4dannjjm 1098 7 , , , cord-023095-4dannjjm 1098 8 NY03 NY03 NNP cord-023095-4dannjjm 1098 9 or or CC cord-023095-4dannjjm 1098 10 Ab4 Ab4 NNP cord-023095-4dannjjm 1098 11 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1098 12 strains strain NNS cord-023095-4dannjjm 1098 13 or or CC cord-023095-4dannjjm 1098 14 kept keep VBN cord-023095-4dannjjm 1098 15 in in IN cord-023095-4dannjjm 1098 16 medium medium NN cord-023095-4dannjjm 1098 17 for for IN cord-023095-4dannjjm 1098 18 24 24 CD cord-023095-4dannjjm 1098 19 hours hour NNS cord-023095-4dannjjm 1098 20 . . . cord-023095-4dannjjm 1099 1 IFN IFN NNP cord-023095-4dannjjm 1099 2 - - HYPH cord-023095-4dannjjm 1099 3 a a NNP cord-023095-4dannjjm 1099 4 , , , cord-023095-4dannjjm 1099 5 IL-10 IL-10 NNP cord-023095-4dannjjm 1099 6 and and CC cord-023095-4dannjjm 1099 7 IL-4 IL-4 NNP cord-023095-4dannjjm 1099 8 secretion secretion NN cord-023095-4dannjjm 1099 9 was be VBD cord-023095-4dannjjm 1099 10 detected detect VBN cord-023095-4dannjjm 1099 11 in in IN cord-023095-4dannjjm 1099 12 the the DT cord-023095-4dannjjm 1099 13 supernatants supernatant NNS cord-023095-4dannjjm 1099 14 by by IN cord-023095-4dannjjm 1099 15 a a DT cord-023095-4dannjjm 1099 16 fluorescent fluorescent JJ cord-023095-4dannjjm 1099 17 bead bead NN cord-023095-4dannjjm 1099 18 - - HYPH cord-023095-4dannjjm 1099 19 based base VBN cord-023095-4dannjjm 1099 20 cytokine cytokine NN cord-023095-4dannjjm 1099 21 assay assay NN cord-023095-4dannjjm 1099 22 . . . cord-023095-4dannjjm 1100 1 The the DT cord-023095-4dannjjm 1100 2 production production NN cord-023095-4dannjjm 1100 3 of of IN cord-023095-4dannjjm 1100 4 IFN IFN NNP cord-023095-4dannjjm 1100 5 - - : cord-023095-4dannjjm 1100 6 a a DT cord-023095-4dannjjm 1100 7 increased increase VBD cord-023095-4dannjjm 1100 8 with with IN cord-023095-4dannjjm 1100 9 increasing increase VBG cord-023095-4dannjjm 1100 10 viral viral JJ cord-023095-4dannjjm 1100 11 doses dose NNS cord-023095-4dannjjm 1100 12 and and CC cord-023095-4dannjjm 1100 13 similarly similarly RB cord-023095-4dannjjm 1100 14 for for IN cord-023095-4dannjjm 1100 15 all all DT cord-023095-4dannjjm 1100 16 three three CD cord-023095-4dannjjm 1100 17 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1100 18 strains strain NNS cord-023095-4dannjjm 1100 19 . . . cord-023095-4dannjjm 1101 1 The the DT cord-023095-4dannjjm 1101 2 production production NN cord-023095-4dannjjm 1101 3 of of IN cord-023095-4dannjjm 1101 4 the the DT cord-023095-4dannjjm 1101 5 antiinflammatory antiinflammatory JJ cord-023095-4dannjjm 1101 6 cytokine cytokine NN cord-023095-4dannjjm 1101 7 IL-10 IL-10 NNP cord-023095-4dannjjm 1101 8 was be VBD cord-023095-4dannjjm 1101 9 significantly significantly RB cord-023095-4dannjjm 1101 10 decreased decrease VBN cord-023095-4dannjjm 1101 11 after after IN cord-023095-4dannjjm 1101 12 Ab4 ab4 NN cord-023095-4dannjjm 1101 13 infection infection NN cord-023095-4dannjjm 1101 14 compared compare VBN cord-023095-4dannjjm 1101 15 to to IN cord-023095-4dannjjm 1101 16 RacL11 racl11 NN cord-023095-4dannjjm 1101 17 and and CC cord-023095-4dannjjm 1101 18 NY03 NY03 NNP cord-023095-4dannjjm 1101 19 strains strain NNS cord-023095-4dannjjm 1101 20 at at IN cord-023095-4dannjjm 1101 21 viral viral JJ cord-023095-4dannjjm 1101 22 infection infection NN cord-023095-4dannjjm 1101 23 doses dose NNS cord-023095-4dannjjm 1101 24 of of IN cord-023095-4dannjjm 1101 25 MOI MOI NNP cord-023095-4dannjjm 1101 26 0.3 0.3 CD cord-023095-4dannjjm 1101 27 - - HYPH cord-023095-4dannjjm 1101 28 1 1 CD cord-023095-4dannjjm 1101 29 . . . cord-023095-4dannjjm 1102 1 At at IN cord-023095-4dannjjm 1102 2 high high JJ cord-023095-4dannjjm 1102 3 doses dose NNS cord-023095-4dannjjm 1102 4 ( ( -LRB- cord-023095-4dannjjm 1102 5 MOI MOI NNP cord-023095-4dannjjm 1102 6 3 3 CD cord-023095-4dannjjm 1102 7 ) ) -RRB- cord-023095-4dannjjm 1102 8 , , , cord-023095-4dannjjm 1102 9 IL-10 IL-10 NNP cord-023095-4dannjjm 1102 10 production production NN cord-023095-4dannjjm 1102 11 was be VBD cord-023095-4dannjjm 1102 12 suppressed suppress VBN cord-023095-4dannjjm 1102 13 by by IN cord-023095-4dannjjm 1102 14 all all DT cord-023095-4dannjjm 1102 15 three three CD cord-023095-4dannjjm 1102 16 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1102 17 strains strain NNS cord-023095-4dannjjm 1102 18 . . . cord-023095-4dannjjm 1103 1 The the DT cord-023095-4dannjjm 1103 2 results result NNS cord-023095-4dannjjm 1103 3 suggested suggest VBD cord-023095-4dannjjm 1103 4 that that IN cord-023095-4dannjjm 1103 5 abortogenic abortogenic NNP cord-023095-4dannjjm 1103 6 and and CC cord-023095-4dannjjm 1103 7 neuropathogenic neuropathogenic NNP cord-023095-4dannjjm 1103 8 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1103 9 strains strain NNS cord-023095-4dannjjm 1103 10 equally equally RB cord-023095-4dannjjm 1103 11 induce induce VBP cord-023095-4dannjjm 1103 12 antiviral antiviral JJ cord-023095-4dannjjm 1103 13 IFN IFN NNP cord-023095-4dannjjm 1103 14 - - : cord-023095-4dannjjm 1103 15 a a DT cord-023095-4dannjjm 1103 16 production production NN cord-023095-4dannjjm 1103 17 in in IN cord-023095-4dannjjm 1103 18 equine equine JJ cord-023095-4dannjjm 1103 19 PBMC PBMC NNS cord-023095-4dannjjm 1103 20 . . . cord-023095-4dannjjm 1104 1 They -PRON- PRP cord-023095-4dannjjm 1104 2 also also RB cord-023095-4dannjjm 1104 3 illustrated illustrate VBD cord-023095-4dannjjm 1104 4 the the DT cord-023095-4dannjjm 1104 5 differences difference NNS cord-023095-4dannjjm 1104 6 in in IN cord-023095-4dannjjm 1104 7 the the DT cord-023095-4dannjjm 1104 8 ability ability NN cord-023095-4dannjjm 1104 9 of of IN cord-023095-4dannjjm 1104 10 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1104 11 strains strain NNS cord-023095-4dannjjm 1104 12 to to TO cord-023095-4dannjjm 1104 13 modulate modulate VB cord-023095-4dannjjm 1104 14 anti anti JJ cord-023095-4dannjjm 1104 15 - - JJ cord-023095-4dannjjm 1104 16 inflammatory inflammatory JJ cord-023095-4dannjjm 1104 17 IL-10 IL-10 NNP cord-023095-4dannjjm 1104 18 . . . cord-023095-4dannjjm 1105 1 Neuropathogenic Neuropathogenic NNP cord-023095-4dannjjm 1105 2 Ab4 ab4 NN cord-023095-4dannjjm 1105 3 strain strain NN cord-023095-4dannjjm 1105 4 had have VBD cord-023095-4dannjjm 1105 5 an an DT cord-023095-4dannjjm 1105 6 increased increase VBN cord-023095-4dannjjm 1105 7 potential potential NN cord-023095-4dannjjm 1105 8 to to IN cord-023095-4dannjjm 1105 9 down down RB cord-023095-4dannjjm 1105 10 - - HYPH cord-023095-4dannjjm 1105 11 regulate regulate VB cord-023095-4dannjjm 1105 12 IL-10 IL-10 NNP cord-023095-4dannjjm 1105 13 production production NN cord-023095-4dannjjm 1105 14 suggesting suggest VBG cord-023095-4dannjjm 1105 15 specific specific JJ cord-023095-4dannjjm 1105 16 viral viral JJ cord-023095-4dannjjm 1105 17 mechanisms mechanism NNS cord-023095-4dannjjm 1105 18 that that WDT cord-023095-4dannjjm 1105 19 interfere interfere VBP cord-023095-4dannjjm 1105 20 with with IN cord-023095-4dannjjm 1105 21 the the DT cord-023095-4dannjjm 1105 22 control control NN cord-023095-4dannjjm 1105 23 of of IN cord-023095-4dannjjm 1105 24 inflammation inflammation NN cord-023095-4dannjjm 1105 25 in in IN cord-023095-4dannjjm 1105 26 the the DT cord-023095-4dannjjm 1105 27 host host NN cord-023095-4dannjjm 1105 28 . . . cord-023095-4dannjjm 1106 1 The the DT cord-023095-4dannjjm 1106 2 variations variation NNS cord-023095-4dannjjm 1106 3 in in IN cord-023095-4dannjjm 1106 4 innate innate JJ cord-023095-4dannjjm 1106 5 IL-10 IL-10 NNP cord-023095-4dannjjm 1106 6 secretion secretion NN cord-023095-4dannjjm 1106 7 might may MD cord-023095-4dannjjm 1106 8 influence influence VB cord-023095-4dannjjm 1106 9 the the DT cord-023095-4dannjjm 1106 10 development development NN cord-023095-4dannjjm 1106 11 of of IN cord-023095-4dannjjm 1106 12 protective protective JJ cord-023095-4dannjjm 1106 13 immunity immunity NN cord-023095-4dannjjm 1106 14 and and CC cord-023095-4dannjjm 1106 15 might may MD cord-023095-4dannjjm 1106 16 offer offer VB cord-023095-4dannjjm 1106 17 an an DT cord-023095-4dannjjm 1106 18 explanation explanation NN cord-023095-4dannjjm 1106 19 why why WRB cord-023095-4dannjjm 1106 20 neuropathogenic neuropathogenic NNP cord-023095-4dannjjm 1106 21 Ab4 Ab4 NNP cord-023095-4dannjjm 1106 22 induces induce VBZ cord-023095-4dannjjm 1106 23 more more RBR cord-023095-4dannjjm 1106 24 severe severe JJ cord-023095-4dannjjm 1106 25 disease disease NN cord-023095-4dannjjm 1106 26 , , , cord-023095-4dannjjm 1106 27 including include VBG cord-023095-4dannjjm 1106 28 myeloencephalopathy myeloencephalopathy NNP cord-023095-4dannjjm 1106 29 , , , cord-023095-4dannjjm 1106 30 than than IN cord-023095-4dannjjm 1106 31 abortogenic abortogenic NNP cord-023095-4dannjjm 1106 32 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1106 33 strains strain NNS cord-023095-4dannjjm 1106 34 . . . cord-023095-4dannjjm 1107 1 Previously previously RB cord-023095-4dannjjm 1107 2 presented present VBN cord-023095-4dannjjm 1107 3 at at IN cord-023095-4dannjjm 1107 4 a a DT cord-023095-4dannjjm 1107 5 conference conference NN cord-023095-4dannjjm 1107 6 of of IN cord-023095-4dannjjm 1107 7 research research NN cord-023095-4dannjjm 1107 8 workers worker NNS cord-023095-4dannjjm 1107 9 in in IN cord-023095-4dannjjm 1107 10 animal animal NN cord-023095-4dannjjm 1107 11 disease disease NN cord-023095-4dannjjm 1107 12 . . . cord-023095-4dannjjm 1108 1 Rhodoccocus rhodoccocus NN cord-023095-4dannjjm 1108 2 equi equi NN cord-023095-4dannjjm 1108 3 is be VBZ cord-023095-4dannjjm 1108 4 the the DT cord-023095-4dannjjm 1108 5 major major JJ cord-023095-4dannjjm 1108 6 cause cause NN cord-023095-4dannjjm 1108 7 of of IN cord-023095-4dannjjm 1108 8 pneumonia pneumonia NN cord-023095-4dannjjm 1108 9 in in IN cord-023095-4dannjjm 1108 10 foals foal NNS cord-023095-4dannjjm 1108 11 during during IN cord-023095-4dannjjm 1108 12 the the DT cord-023095-4dannjjm 1108 13 first first JJ cord-023095-4dannjjm 1108 14 six six CD cord-023095-4dannjjm 1108 15 months month NNS cord-023095-4dannjjm 1108 16 and and CC cord-023095-4dannjjm 1108 17 control control NN cord-023095-4dannjjm 1108 18 measures measure NNS cord-023095-4dannjjm 1108 19 are be VBP cord-023095-4dannjjm 1108 20 frequently frequently RB cord-023095-4dannjjm 1108 21 ineffective ineffective JJ cord-023095-4dannjjm 1108 22 . . . cord-023095-4dannjjm 1109 1 Treatment treatment NN cord-023095-4dannjjm 1109 2 protocols protocol NNS cord-023095-4dannjjm 1109 3 are be VBP cord-023095-4dannjjm 1109 4 long long JJ cord-023095-4dannjjm 1109 5 , , , cord-023095-4dannjjm 1109 6 expensive expensive JJ cord-023095-4dannjjm 1109 7 and and CC cord-023095-4dannjjm 1109 8 do do VBP cord-023095-4dannjjm 1109 9 not not RB cord-023095-4dannjjm 1109 10 always always RB cord-023095-4dannjjm 1109 11 produce produce VB cord-023095-4dannjjm 1109 12 good good JJ cord-023095-4dannjjm 1109 13 results result NNS cord-023095-4dannjjm 1109 14 . . . cord-023095-4dannjjm 1110 1 Rhodococcosis rhodococcosis NN cord-023095-4dannjjm 1110 2 prevention prevention NN cord-023095-4dannjjm 1110 3 through through IN cord-023095-4dannjjm 1110 4 immunization immunization NN cord-023095-4dannjjm 1110 5 of of IN cord-023095-4dannjjm 1110 6 foals foal NNS cord-023095-4dannjjm 1110 7 using use VBG cord-023095-4dannjjm 1110 8 a a DT cord-023095-4dannjjm 1110 9 safe safe JJ cord-023095-4dannjjm 1110 10 and and CC cord-023095-4dannjjm 1110 11 efficient efficient JJ cord-023095-4dannjjm 1110 12 vaccine vaccine NN cord-023095-4dannjjm 1110 13 is be VBZ cord-023095-4dannjjm 1110 14 still still RB cord-023095-4dannjjm 1110 15 a a DT cord-023095-4dannjjm 1110 16 challenge challenge NN cord-023095-4dannjjm 1110 17 . . . cord-023095-4dannjjm 1111 1 Recent recent JJ cord-023095-4dannjjm 1111 2 studies study NNS cord-023095-4dannjjm 1111 3 are be VBP cord-023095-4dannjjm 1111 4 based base VBN cord-023095-4dannjjm 1111 5 on on IN cord-023095-4dannjjm 1111 6 the the DT cord-023095-4dannjjm 1111 7 use use NN cord-023095-4dannjjm 1111 8 of of IN cord-023095-4dannjjm 1111 9 the the DT cord-023095-4dannjjm 1111 10 virulence virulence NN cord-023095-4dannjjm 1111 11 associated associate VBD cord-023095-4dannjjm 1111 12 protein protein NN cord-023095-4dannjjm 1111 13 A a NN cord-023095-4dannjjm 1111 14 ( ( -LRB- cord-023095-4dannjjm 1111 15 vapA vapa NN cord-023095-4dannjjm 1111 16 ) ) -RRB- cord-023095-4dannjjm 1111 17 which which WDT cord-023095-4dannjjm 1111 18 has have VBZ cord-023095-4dannjjm 1111 19 been be VBN cord-023095-4dannjjm 1111 20 described describe VBN cord-023095-4dannjjm 1111 21 as as IN cord-023095-4dannjjm 1111 22 an an DT cord-023095-4dannjjm 1111 23 important important JJ cord-023095-4dannjjm 1111 24 inducer inducer NN cord-023095-4dannjjm 1111 25 of of IN cord-023095-4dannjjm 1111 26 immunity immunity NN cord-023095-4dannjjm 1111 27 against against IN cord-023095-4dannjjm 1111 28 R. R. NNP cord-023095-4dannjjm 1111 29 equi equi NN cord-023095-4dannjjm 1111 30 . . . cord-023095-4dannjjm 1112 1 The the DT cord-023095-4dannjjm 1112 2 present present JJ cord-023095-4dannjjm 1112 3 study study NN cord-023095-4dannjjm 1112 4 evaluated evaluate VBD cord-023095-4dannjjm 1112 5 the the DT cord-023095-4dannjjm 1112 6 clinical clinical JJ cord-023095-4dannjjm 1112 7 and and CC cord-023095-4dannjjm 1112 8 immune immune JJ cord-023095-4dannjjm 1112 9 response response NN cord-023095-4dannjjm 1112 10 of of IN cord-023095-4dannjjm 1112 11 foals foal NNS cord-023095-4dannjjm 1112 12 vaccinated vaccinate VBN cord-023095-4dannjjm 1112 13 with with IN cord-023095-4dannjjm 1112 14 an an DT cord-023095-4dannjjm 1112 15 attenuated attenuated JJ cord-023095-4dannjjm 1112 16 strain strain NN cord-023095-4dannjjm 1112 17 of of IN cord-023095-4dannjjm 1112 18 S. S. NNP cord-023095-4dannjjm 1112 19 enterica enterica NNP cord-023095-4dannjjm 1112 20 typhimurium typhimurium NNP cord-023095-4dannjjm 1112 21 expressing express VBG cord-023095-4dannjjm 1112 22 VapA VapA NNP cord-023095-4dannjjm 1112 23 antigen antigen NNP cord-023095-4dannjjm 1112 24 ( ( -LRB- cord-023095-4dannjjm 1112 25 test test NN cord-023095-4dannjjm 1112 26 group group NN cord-023095-4dannjjm 1112 27 ) ) -RRB- cord-023095-4dannjjm 1112 28 or or CC cord-023095-4dannjjm 1112 29 S. S. NNP cord-023095-4dannjjm 1112 30 enterica enterica NNP cord-023095-4dannjjm 1112 31 typhimurium typhimurium NN cord-023095-4dannjjm 1112 32 without without IN cord-023095-4dannjjm 1112 33 the the DT cord-023095-4dannjjm 1112 34 vapA vapa CD cord-023095-4dannjjm 1112 35 gene gene NN cord-023095-4dannjjm 1112 36 ( ( -LRB- cord-023095-4dannjjm 1112 37 control control NNP cord-023095-4dannjjm 1112 38 group group NN cord-023095-4dannjjm 1112 39 ) ) -RRB- cord-023095-4dannjjm 1112 40 , , , cord-023095-4dannjjm 1112 41 previous previous JJ cord-023095-4dannjjm 1112 42 to to IN cord-023095-4dannjjm 1112 43 and and CC cord-023095-4dannjjm 1112 44 following follow VBG cord-023095-4dannjjm 1112 45 experimental experimental JJ cord-023095-4dannjjm 1112 46 challenge challenge NN cord-023095-4dannjjm 1112 47 . . . cord-023095-4dannjjm 1113 1 Two two CD cord-023095-4dannjjm 1113 2 experimental experimental JJ cord-023095-4dannjjm 1113 3 phases phase NNS cord-023095-4dannjjm 1113 4 were be VBD cord-023095-4dannjjm 1113 5 established establish VBN cord-023095-4dannjjm 1113 6 according accord VBG cord-023095-4dannjjm 1113 7 to to IN cord-023095-4dannjjm 1113 8 the the DT cord-023095-4dannjjm 1113 9 immunization immunization NN cord-023095-4dannjjm 1113 10 route route NN cord-023095-4dannjjm 1113 11 : : : cord-023095-4dannjjm 1113 12 intranasal intranasal NN cord-023095-4dannjjm 1113 13 or or CC cord-023095-4dannjjm 1113 14 oral oral JJ cord-023095-4dannjjm 1113 15 vaccination vaccination NN cord-023095-4dannjjm 1113 16 up up IN cord-023095-4dannjjm 1113 17 to to TO cord-023095-4dannjjm 1113 18 12 12 CD cord-023095-4dannjjm 1113 19 hrs hrs NN cord-023095-4dannjjm 1113 20 following follow VBG cord-023095-4dannjjm 1113 21 birth birth NN cord-023095-4dannjjm 1113 22 and and CC cord-023095-4dannjjm 1113 23 at at IN cord-023095-4dannjjm 1113 24 14 14 CD cord-023095-4dannjjm 1113 25 days day NNS cord-023095-4dannjjm 1113 26 of of IN cord-023095-4dannjjm 1113 27 age age NN cord-023095-4dannjjm 1113 28 . . . cord-023095-4dannjjm 1114 1 The the DT cord-023095-4dannjjm 1114 2 experimental experimental JJ cord-023095-4dannjjm 1114 3 and and CC cord-023095-4dannjjm 1114 4 control control NN cord-023095-4dannjjm 1114 5 groups group NNS cord-023095-4dannjjm 1114 6 were be VBD cord-023095-4dannjjm 1114 7 challenged challenge VBN cord-023095-4dannjjm 1114 8 on on IN cord-023095-4dannjjm 1114 9 day day NN cord-023095-4dannjjm 1114 10 28 28 CD cord-023095-4dannjjm 1114 11 with with IN cord-023095-4dannjjm 1114 12 a a DT cord-023095-4dannjjm 1114 13 virulent virulent JJ cord-023095-4dannjjm 1114 14 stain stain NN cord-023095-4dannjjm 1114 15 of of IN cord-023095-4dannjjm 1114 16 R. R. NNP cord-023095-4dannjjm 1114 17 equi equi NN cord-023095-4dannjjm 1114 18 . . . cord-023095-4dannjjm 1115 1 Clinical clinical JJ cord-023095-4dannjjm 1115 2 examination examination NN cord-023095-4dannjjm 1115 3 , , , cord-023095-4dannjjm 1115 4 CBC CBC NNP cord-023095-4dannjjm 1115 5 and and CC cord-023095-4dannjjm 1115 6 image image NN cord-023095-4dannjjm 1115 7 complementary complementary JJ cord-023095-4dannjjm 1115 8 exams exam NNS cord-023095-4dannjjm 1115 9 were be VBD cord-023095-4dannjjm 1115 10 used use VBN cord-023095-4dannjjm 1115 11 to to TO cord-023095-4dannjjm 1115 12 evaluate evaluate VB cord-023095-4dannjjm 1115 13 the the DT cord-023095-4dannjjm 1115 14 development development NN cord-023095-4dannjjm 1115 15 of of IN cord-023095-4dannjjm 1115 16 clinical clinical JJ cord-023095-4dannjjm 1115 17 signs sign NNS cord-023095-4dannjjm 1115 18 . . . cord-023095-4dannjjm 1116 1 Immune immune JJ cord-023095-4dannjjm 1116 2 response response NN cord-023095-4dannjjm 1116 3 patterns pattern NNS cord-023095-4dannjjm 1116 4 were be VBD cord-023095-4dannjjm 1116 5 evaluated evaluate VBN cord-023095-4dannjjm 1116 6 though though IN cord-023095-4dannjjm 1116 7 immunoglobulin immunoglobulin NN cord-023095-4dannjjm 1116 8 dosage dosage NN cord-023095-4dannjjm 1116 9 , , , cord-023095-4dannjjm 1116 10 cytokine cytokine JJ cord-023095-4dannjjm 1116 11 expression expression NN cord-023095-4dannjjm 1116 12 , , , cord-023095-4dannjjm 1116 13 lymphocyte lymphocyte NN cord-023095-4dannjjm 1116 14 proliferation proliferation NN cord-023095-4dannjjm 1116 15 assays assay NNS cord-023095-4dannjjm 1116 16 , , , cord-023095-4dannjjm 1116 17 isolation isolation NN cord-023095-4dannjjm 1116 18 of of IN cord-023095-4dannjjm 1116 19 R. R. NNP cord-023095-4dannjjm 1116 20 equi equi NN cord-023095-4dannjjm 1116 21 and and CC cord-023095-4dannjjm 1116 22 cytological cytological JJ cord-023095-4dannjjm 1116 23 profiles profile NNS cord-023095-4dannjjm 1116 24 of of IN cord-023095-4dannjjm 1116 25 TBW TBW NNP cord-023095-4dannjjm 1116 26 . . . cord-023095-4dannjjm 1117 1 Clinical clinical JJ cord-023095-4dannjjm 1117 2 manifestation manifestation NN cord-023095-4dannjjm 1117 3 was be VBD cord-023095-4dannjjm 1117 4 less less RBR cord-023095-4dannjjm 1117 5 intense intense JJ cord-023095-4dannjjm 1117 6 in in IN cord-023095-4dannjjm 1117 7 the the DT cord-023095-4dannjjm 1117 8 test test NN cord-023095-4dannjjm 1117 9 group group NN cord-023095-4dannjjm 1117 10 during during IN cord-023095-4dannjjm 1117 11 the the DT cord-023095-4dannjjm 1117 12 second second JJ cord-023095-4dannjjm 1117 13 experimental experimental JJ cord-023095-4dannjjm 1117 14 phase phase NN cord-023095-4dannjjm 1117 15 , , , cord-023095-4dannjjm 1117 16 and and CC cord-023095-4dannjjm 1117 17 death death NN cord-023095-4dannjjm 1117 18 occurred occur VBD cord-023095-4dannjjm 1117 19 only only RB cord-023095-4dannjjm 1117 20 in in IN cord-023095-4dannjjm 1117 21 the the DT cord-023095-4dannjjm 1117 22 control control NN cord-023095-4dannjjm 1117 23 group group NN cord-023095-4dannjjm 1117 24 ( ( -LRB- cord-023095-4dannjjm 1117 25 2/3 2/3 CD cord-023095-4dannjjm 1117 26 ) ) -RRB- cord-023095-4dannjjm 1117 27 and and CC cord-023095-4dannjjm 1117 28 was be VBD cord-023095-4dannjjm 1117 29 due due JJ cord-023095-4dannjjm 1117 30 to to IN cord-023095-4dannjjm 1117 31 R. R. NNP cord-023095-4dannjjm 1117 32 equi equi JJ cord-023095-4dannjjm 1117 33 pneumonia pneumonia NN cord-023095-4dannjjm 1117 34 . . . cord-023095-4dannjjm 1118 1 The the DT cord-023095-4dannjjm 1118 2 test test NN cord-023095-4dannjjm 1118 3 group group NN cord-023095-4dannjjm 1118 4 produced produce VBD cord-023095-4dannjjm 1118 5 a a DT cord-023095-4dannjjm 1118 6 more more RBR cord-023095-4dannjjm 1118 7 intense intense JJ cord-023095-4dannjjm 1118 8 IgGb IgGb NNP cord-023095-4dannjjm 1118 9 response response NN cord-023095-4dannjjm 1118 10 when when WRB cord-023095-4dannjjm 1118 11 compared compare VBN cord-023095-4dannjjm 1118 12 to to IN cord-023095-4dannjjm 1118 13 controls control NNS cord-023095-4dannjjm 1118 14 however however RB cord-023095-4dannjjm 1118 15 no no DT cord-023095-4dannjjm 1118 16 statistical statistical JJ cord-023095-4dannjjm 1118 17 difference difference NN cord-023095-4dannjjm 1118 18 was be VBD cord-023095-4dannjjm 1118 19 observed observe VBN cord-023095-4dannjjm 1118 20 . . . cord-023095-4dannjjm 1119 1 Lymphoproliferation lymphoproliferation NN cord-023095-4dannjjm 1119 2 and and CC cord-023095-4dannjjm 1119 3 Th1 th1 NN cord-023095-4dannjjm 1119 4 cytokine cytokine NN cord-023095-4dannjjm 1119 5 expression expression NN cord-023095-4dannjjm 1119 6 were be VBD cord-023095-4dannjjm 1119 7 higher high JJR cord-023095-4dannjjm 1119 8 in in IN cord-023095-4dannjjm 1119 9 the the DT cord-023095-4dannjjm 1119 10 test test NN cord-023095-4dannjjm 1119 11 group group NN cord-023095-4dannjjm 1119 12 . . . cord-023095-4dannjjm 1120 1 In in IN cord-023095-4dannjjm 1120 2 contrast contrast NN cord-023095-4dannjjm 1120 3 , , , cord-023095-4dannjjm 1120 4 controls control NNS cord-023095-4dannjjm 1120 5 produced produce VBD cord-023095-4dannjjm 1120 6 an an DT cord-023095-4dannjjm 1120 7 IL-4 IL-4 NNP cord-023095-4dannjjm 1120 8 response response NN cord-023095-4dannjjm 1120 9 . . . cord-023095-4dannjjm 1121 1 Local local JJ cord-023095-4dannjjm 1121 2 IgA iga NN cord-023095-4dannjjm 1121 3 was be VBD cord-023095-4dannjjm 1121 4 significantly significantly RB cord-023095-4dannjjm 1121 5 higher high JJR cord-023095-4dannjjm 1121 6 in in IN cord-023095-4dannjjm 1121 7 animals animal NNS cord-023095-4dannjjm 1121 8 immunized immunize VBN cord-023095-4dannjjm 1121 9 with with IN cord-023095-4dannjjm 1121 10 Salmonella salmonella NN cord-023095-4dannjjm 1121 11 carrying carry VBG cord-023095-4dannjjm 1121 12 vapA. vapA. NNP cord-023095-4dannjjm 1122 1 Immunization immunization NN cord-023095-4dannjjm 1122 2 protocols protocol NNS cord-023095-4dannjjm 1122 3 produced produce VBD cord-023095-4dannjjm 1122 4 no no DT cord-023095-4dannjjm 1122 5 severe severe JJ cord-023095-4dannjjm 1122 6 toxic toxic JJ cord-023095-4dannjjm 1122 7 effects effect NNS cord-023095-4dannjjm 1122 8 . . . cord-023095-4dannjjm 1123 1 The the DT cord-023095-4dannjjm 1123 2 vaccination vaccination NN cord-023095-4dannjjm 1123 3 of of IN cord-023095-4dannjjm 1123 4 neonatal neonatal JJ cord-023095-4dannjjm 1123 5 foals foal NNS cord-023095-4dannjjm 1123 6 with with IN cord-023095-4dannjjm 1123 7 S. S. NNP cord-023095-4dannjjm 1123 8 enterica enterica NNP cord-023095-4dannjjm 1123 9 typhimurium typhimurium NNP cord-023095-4dannjjm 1123 10 expressing express VBG cord-023095-4dannjjm 1123 11 VapA VapA NNP cord-023095-4dannjjm 1123 12 was be VBD cord-023095-4dannjjm 1123 13 considered consider VBN cord-023095-4dannjjm 1123 14 safe safe JJ cord-023095-4dannjjm 1123 15 , , , cord-023095-4dannjjm 1123 16 produced produce VBD cord-023095-4dannjjm 1123 17 efficient efficient JJ cord-023095-4dannjjm 1123 18 modulation modulation NN cord-023095-4dannjjm 1123 19 of of IN cord-023095-4dannjjm 1123 20 the the DT cord-023095-4dannjjm 1123 21 immune immune JJ cord-023095-4dannjjm 1123 22 response response NN cord-023095-4dannjjm 1123 23 and and CC cord-023095-4dannjjm 1123 24 is be VBZ cord-023095-4dannjjm 1123 25 apparently apparently RB cord-023095-4dannjjm 1123 26 able able JJ cord-023095-4dannjjm 1123 27 to to TO cord-023095-4dannjjm 1123 28 protect protect VB cord-023095-4dannjjm 1123 29 against against IN cord-023095-4dannjjm 1123 30 experimental experimental JJ cord-023095-4dannjjm 1123 31 R.equi r.equi JJ cord-023095-4dannjjm 1123 32 infection infection NN cord-023095-4dannjjm 1123 33 . . . cord-023095-4dannjjm 1124 1 This this DT cord-023095-4dannjjm 1124 2 study study NN cord-023095-4dannjjm 1124 3 was be VBD cord-023095-4dannjjm 1124 4 conducted conduct VBN cord-023095-4dannjjm 1124 5 to to TO cord-023095-4dannjjm 1124 6 test test VB cord-023095-4dannjjm 1124 7 the the DT cord-023095-4dannjjm 1124 8 hypothesis hypothesis NN cord-023095-4dannjjm 1124 9 that that IN cord-023095-4dannjjm 1124 10 the the DT cord-023095-4dannjjm 1124 11 32 32 CD cord-023095-4dannjjm 1124 12 kD kD NNP cord-023095-4dannjjm 1124 13 protein protein NN cord-023095-4dannjjm 1124 14 , , , cord-023095-4dannjjm 1124 15 Myristolated Myristolated NNP cord-023095-4dannjjm 1124 16 Alanine Alanine NNP cord-023095-4dannjjm 1124 17 - - HYPH cord-023095-4dannjjm 1124 18 Rich Rich NNP cord-023095-4dannjjm 1124 19 C C NNP cord-023095-4dannjjm 1124 20 - - HYPH cord-023095-4dannjjm 1124 21 Kinase Kinase NNP cord-023095-4dannjjm 1124 22 Substrate Substrate NNP cord-023095-4dannjjm 1124 23 ( ( -LRB- cord-023095-4dannjjm 1124 24 MARCKS MARCKS NNP cord-023095-4dannjjm 1124 25 ) ) -RRB- cord-023095-4dannjjm 1124 26 , , , cord-023095-4dannjjm 1124 27 is be VBZ cord-023095-4dannjjm 1124 28 involved involve VBN cord-023095-4dannjjm 1124 29 in in IN cord-023095-4dannjjm 1124 30 equine equine JJ cord-023095-4dannjjm 1124 31 neutrophil neutrophil NN cord-023095-4dannjjm 1124 32 migration migration NN cord-023095-4dannjjm 1124 33 and and CC cord-023095-4dannjjm 1124 34 adhesion adhesion NN cord-023095-4dannjjm 1124 35 . . . cord-023095-4dannjjm 1125 1 In in IN cord-023095-4dannjjm 1125 2 other other JJ cord-023095-4dannjjm 1125 3 species specie NNS cord-023095-4dannjjm 1125 4 , , , cord-023095-4dannjjm 1125 5 MARCKS MARCKS NNP cord-023095-4dannjjm 1125 6 phosphorylation phosphorylation NN cord-023095-4dannjjm 1125 7 and and CC cord-023095-4dannjjm 1125 8 dephosphorylation dephosphorylation NN cord-023095-4dannjjm 1125 9 causes cause VBZ cord-023095-4dannjjm 1125 10 the the DT cord-023095-4dannjjm 1125 11 protein protein NN cord-023095-4dannjjm 1125 12 to to TO cord-023095-4dannjjm 1125 13 cycle cycle VB cord-023095-4dannjjm 1125 14 between between IN cord-023095-4dannjjm 1125 15 the the DT cord-023095-4dannjjm 1125 16 cell cell NN cord-023095-4dannjjm 1125 17 membrane membrane NN cord-023095-4dannjjm 1125 18 and and CC cord-023095-4dannjjm 1125 19 cytosol cytosol NN cord-023095-4dannjjm 1125 20 , , , cord-023095-4dannjjm 1125 21 respectively respectively RB cord-023095-4dannjjm 1125 22 . . . cord-023095-4dannjjm 1126 1 To to TO cord-023095-4dannjjm 1126 2 investigate investigate VB cord-023095-4dannjjm 1126 3 MARCKS MARCKS NNP cord-023095-4dannjjm 1126 4 phosphorylation phosphorylation NN cord-023095-4dannjjm 1126 5 in in IN cord-023095-4dannjjm 1126 6 horses horse NNS cord-023095-4dannjjm 1126 7 , , , cord-023095-4dannjjm 1126 8 neutrophils neutrophil NNS cord-023095-4dannjjm 1126 9 were be VBD cord-023095-4dannjjm 1126 10 isolated isolate VBN cord-023095-4dannjjm 1126 11 from from IN cord-023095-4dannjjm 1126 12 whole whole JJ cord-023095-4dannjjm 1126 13 blood blood NN cord-023095-4dannjjm 1126 14 and and CC cord-023095-4dannjjm 1126 15 stimulated stimulate VBD cord-023095-4dannjjm 1126 16 with with IN cord-023095-4dannjjm 1126 17 platelet platelet NN cord-023095-4dannjjm 1126 18 activating activate VBG cord-023095-4dannjjm 1126 19 factor factor NN cord-023095-4dannjjm 1126 20 ( ( -LRB- cord-023095-4dannjjm 1126 21 PAF PAF NNP cord-023095-4dannjjm 1126 22 ) ) -RRB- cord-023095-4dannjjm 1126 23 , , , cord-023095-4dannjjm 1126 24 leukotriene leukotriene NN cord-023095-4dannjjm 1126 25 B B NNP cord-023095-4dannjjm 1126 26 4 4 CD cord-023095-4dannjjm 1127 1 ( ( -LRB- cord-023095-4dannjjm 1127 2 LTB LTB NNP cord-023095-4dannjjm 1127 3 4 4 CD cord-023095-4dannjjm 1127 4 ) ) -RRB- cord-023095-4dannjjm 1127 5 or or CC cord-023095-4dannjjm 1127 6 phorbol phorbol NNP cord-023095-4dannjjm 1127 7 myristate myristate NNP cord-023095-4dannjjm 1127 8 acetate acetate NNP cord-023095-4dannjjm 1127 9 ( ( -LRB- cord-023095-4dannjjm 1127 10 PMA PMA NNP cord-023095-4dannjjm 1127 11 ) ) -RRB- cord-023095-4dannjjm 1127 12 . . . cord-023095-4dannjjm 1128 1 Western western JJ cord-023095-4dannjjm 1128 2 blot blot NN cord-023095-4dannjjm 1128 3 was be VBD cord-023095-4dannjjm 1128 4 performed perform VBN cord-023095-4dannjjm 1128 5 using use VBG cord-023095-4dannjjm 1128 6 specific specific JJ cord-023095-4dannjjm 1128 7 phospho phospho NNP cord-023095-4dannjjm 1128 8 - - HYPH cord-023095-4dannjjm 1128 9 MARCKS MARCKS NNP cord-023095-4dannjjm 1128 10 and and CC cord-023095-4dannjjm 1128 11 total total JJ cord-023095-4dannjjm 1128 12 MARCKS MARCKS NNP cord-023095-4dannjjm 1128 13 primary primary JJ cord-023095-4dannjjm 1128 14 antibodies antibody NNS cord-023095-4dannjjm 1128 15 . . . cord-023095-4dannjjm 1129 1 These these DT cord-023095-4dannjjm 1129 2 results result NNS cord-023095-4dannjjm 1129 3 determined determine VBD cord-023095-4dannjjm 1129 4 MARCKS MARCKS NNP cord-023095-4dannjjm 1129 5 phosphorylation phosphorylation NN cord-023095-4dannjjm 1129 6 is be VBZ cord-023095-4dannjjm 1129 7 maximal maximal JJ cord-023095-4dannjjm 1129 8 30 30 CD cord-023095-4dannjjm 1129 9 seconds second NNS cord-023095-4dannjjm 1129 10 following follow VBG cord-023095-4dannjjm 1129 11 stimulation stimulation NN cord-023095-4dannjjm 1129 12 and and CC cord-023095-4dannjjm 1129 13 that that IN cord-023095-4dannjjm 1129 14 dephosphorylation dephosphorylation NN cord-023095-4dannjjm 1129 15 occurs occur VBZ cord-023095-4dannjjm 1129 16 within within IN cord-023095-4dannjjm 1129 17 3 3 CD cord-023095-4dannjjm 1129 18 minutes minute NNS cord-023095-4dannjjm 1129 19 . . . cord-023095-4dannjjm 1130 1 To to TO cord-023095-4dannjjm 1130 2 investigate investigate VB cord-023095-4dannjjm 1130 3 the the DT cord-023095-4dannjjm 1130 4 requirement requirement NN cord-023095-4dannjjm 1130 5 for for IN cord-023095-4dannjjm 1130 6 MARCKS marck NNS cord-023095-4dannjjm 1130 7 in in IN cord-023095-4dannjjm 1130 8 equine equine JJ cord-023095-4dannjjm 1130 9 neutrophil neutrophil NN cord-023095-4dannjjm 1130 10 chemotaxis chemotaxis NN cord-023095-4dannjjm 1130 11 , , , cord-023095-4dannjjm 1130 12 isolated isolated JJ cord-023095-4dannjjm 1130 13 neutrophils neutrophil NNS cord-023095-4dannjjm 1130 14 were be VBD cord-023095-4dannjjm 1130 15 pre pre VBN cord-023095-4dannjjm 1130 16 - - VBN cord-023095-4dannjjm 1130 17 treated treat VBN cord-023095-4dannjjm 1130 18 with with IN cord-023095-4dannjjm 1130 19 MANS MANS NNP cord-023095-4dannjjm 1130 20 ( ( -LRB- cord-023095-4dannjjm 1130 21 a a DT cord-023095-4dannjjm 1130 22 cell cell NN cord-023095-4dannjjm 1130 23 permeant permeant JJ cord-023095-4dannjjm 1130 24 peptide peptide NN cord-023095-4dannjjm 1130 25 identical identical JJ cord-023095-4dannjjm 1130 26 to to IN cord-023095-4dannjjm 1130 27 the the DT cord-023095-4dannjjm 1130 28 N n CD cord-023095-4dannjjm 1130 29 - - HYPH cord-023095-4dannjjm 1130 30 terminal terminal JJ cord-023095-4dannjjm 1130 31 24 24 CD cord-023095-4dannjjm 1130 32 amino amino NN cord-023095-4dannjjm 1130 33 acids acid NNS cord-023095-4dannjjm 1130 34 of of IN cord-023095-4dannjjm 1130 35 MARCKS MARCKS NNP cord-023095-4dannjjm 1130 36 ) ) -RRB- cord-023095-4dannjjm 1131 1 , , , cord-023095-4dannjjm 1131 2 RNS RNS NNP cord-023095-4dannjjm 1131 3 ( ( -LRB- cord-023095-4dannjjm 1131 4 a a DT cord-023095-4dannjjm 1131 5 control control NN cord-023095-4dannjjm 1131 6 peptide peptide NN cord-023095-4dannjjm 1131 7 ) ) -RRB- cord-023095-4dannjjm 1131 8 or or CC cord-023095-4dannjjm 1131 9 vehicle vehicle NN cord-023095-4dannjjm 1131 10 control control NN cord-023095-4dannjjm 1131 11 ( ( -LRB- cord-023095-4dannjjm 1131 12 VC VC NNP cord-023095-4dannjjm 1131 13 ) ) -RRB- cord-023095-4dannjjm 1132 1 prior prior RB cord-023095-4dannjjm 1132 2 to to IN cord-023095-4dannjjm 1132 3 a a DT cord-023095-4dannjjm 1132 4 migration migration NN cord-023095-4dannjjm 1132 5 assay assay NN cord-023095-4dannjjm 1132 6 toward toward IN cord-023095-4dannjjm 1132 7 known know VBN cord-023095-4dannjjm 1132 8 neutrophil neutrophil NN cord-023095-4dannjjm 1132 9 chemoattractants chemoattractant NNS cord-023095-4dannjjm 1132 10 ( ( -LRB- cord-023095-4dannjjm 1132 11 LTB LTB NNP cord-023095-4dannjjm 1132 12 4 4 CD cord-023095-4dannjjm 1132 13 or or CC cord-023095-4dannjjm 1132 14 PAF PAF NNP cord-023095-4dannjjm 1132 15 ) ) -RRB- cord-023095-4dannjjm 1132 16 . . . cord-023095-4dannjjm 1133 1 Pre pre JJ cord-023095-4dannjjm 1133 2 - - JJ cord-023095-4dannjjm 1133 3 treatment treatment NN cord-023095-4dannjjm 1133 4 of of IN cord-023095-4dannjjm 1133 5 equine equine JJ cord-023095-4dannjjm 1133 6 neutrophils neutrophil NNS cord-023095-4dannjjm 1133 7 with with IN cord-023095-4dannjjm 1133 8 MANS MANS NNP cord-023095-4dannjjm 1133 9 significantly significantly RB cord-023095-4dannjjm 1133 10 inhibited inhibit VBN cord-023095-4dannjjm 1133 11 migration migration NN cord-023095-4dannjjm 1133 12 while while IN cord-023095-4dannjjm 1133 13 RNS RNS NNP cord-023095-4dannjjm 1133 14 pre pre JJ cord-023095-4dannjjm 1133 15 - - JJ cord-023095-4dannjjm 1133 16 treatment treatment NN cord-023095-4dannjjm 1133 17 had have VBD cord-023095-4dannjjm 1133 18 no no DT cord-023095-4dannjjm 1133 19 effect effect NN cord-023095-4dannjjm 1133 20 . . . cord-023095-4dannjjm 1134 1 To to TO cord-023095-4dannjjm 1134 2 investigate investigate VB cord-023095-4dannjjm 1134 3 MARCKS MARCKS NNP cord-023095-4dannjjm 1134 4 requirement requirement NN cord-023095-4dannjjm 1134 5 in in IN cord-023095-4dannjjm 1134 6 equine equine JJ cord-023095-4dannjjm 1134 7 neutrophil neutrophil NN cord-023095-4dannjjm 1134 8 adhesion adhesion NN cord-023095-4dannjjm 1134 9 , , , cord-023095-4dannjjm 1134 10 MANS MANS NNP cord-023095-4dannjjm 1134 11 , , , cord-023095-4dannjjm 1134 12 RNS RNS NNP cord-023095-4dannjjm 1134 13 or or CC cord-023095-4dannjjm 1134 14 VC VC NNP cord-023095-4dannjjm 1134 15 treated treat VBN cord-023095-4dannjjm 1134 16 cells cell NNS cord-023095-4dannjjm 1134 17 were be VBD cord-023095-4dannjjm 1134 18 stimulated stimulate VBN cord-023095-4dannjjm 1134 19 to to TO cord-023095-4dannjjm 1134 20 adhere adhere VB cord-023095-4dannjjm 1134 21 to to IN cord-023095-4dannjjm 1134 22 Immulon Immulon NNP cord-023095-4dannjjm 1134 23 2 2 CD cord-023095-4dannjjm 1134 24 plates plate NNS cord-023095-4dannjjm 1134 25 coated coat VBN cord-023095-4dannjjm 1134 26 with with IN cord-023095-4dannjjm 1134 27 5 5 CD cord-023095-4dannjjm 1134 28 % % NN cord-023095-4dannjjm 1134 29 FBS FBS NNP cord-023095-4dannjjm 1134 30 . . . cord-023095-4dannjjm 1135 1 Pre pre JJ cord-023095-4dannjjm 1135 2 - - JJ cord-023095-4dannjjm 1135 3 treatment treatment NN cord-023095-4dannjjm 1135 4 of of IN cord-023095-4dannjjm 1135 5 equine equine JJ cord-023095-4dannjjm 1135 6 neutrophils neutrophil NNS cord-023095-4dannjjm 1135 7 with with IN cord-023095-4dannjjm 1135 8 MANS MANS NNP cord-023095-4dannjjm 1135 9 significantly significantly RB cord-023095-4dannjjm 1135 10 inhibited inhibited JJ cord-023095-4dannjjm 1135 11 adhesion adhesion NN cord-023095-4dannjjm 1135 12 while while IN cord-023095-4dannjjm 1135 13 RNS RNS NNP cord-023095-4dannjjm 1135 14 pre pre JJ cord-023095-4dannjjm 1135 15 - - JJ cord-023095-4dannjjm 1135 16 treatment treatment NN cord-023095-4dannjjm 1135 17 had have VBD cord-023095-4dannjjm 1135 18 no no DT cord-023095-4dannjjm 1135 19 effect effect NN cord-023095-4dannjjm 1135 20 . . . cord-023095-4dannjjm 1136 1 Inhibition inhibition NN cord-023095-4dannjjm 1136 2 of of IN cord-023095-4dannjjm 1136 3 MARCKS MARCKS NNPS cord-023095-4dannjjm 1136 4 using use VBG cord-023095-4dannjjm 1136 5 a a DT cord-023095-4dannjjm 1136 6 cell cell NN cord-023095-4dannjjm 1136 7 permeant permeant JJ cord-023095-4dannjjm 1136 8 peptide peptide NN cord-023095-4dannjjm 1136 9 identical identical JJ cord-023095-4dannjjm 1136 10 to to IN cord-023095-4dannjjm 1136 11 the the DT cord-023095-4dannjjm 1136 12 protein protein NN cord-023095-4dannjjm 1136 13 's 's POS cord-023095-4dannjjm 1136 14 N n CD cord-023095-4dannjjm 1136 15 - - HYPH cord-023095-4dannjjm 1136 16 terminus terminus NN cord-023095-4dannjjm 1136 17 significantly significantly RB cord-023095-4dannjjm 1136 18 inhibited inhibit VBN cord-023095-4dannjjm 1136 19 equine equine JJ cord-023095-4dannjjm 1136 20 neutrophil neutrophil NN cord-023095-4dannjjm 1136 21 adhesion adhesion NN cord-023095-4dannjjm 1136 22 and and CC cord-023095-4dannjjm 1136 23 migration migration NN cord-023095-4dannjjm 1136 24 . . . cord-023095-4dannjjm 1137 1 These these DT cord-023095-4dannjjm 1137 2 results result NNS cord-023095-4dannjjm 1137 3 indicate indicate VBP cord-023095-4dannjjm 1137 4 that that IN cord-023095-4dannjjm 1137 5 MARCKS MARCKS NNP cord-023095-4dannjjm 1137 6 is be VBZ cord-023095-4dannjjm 1137 7 an an DT cord-023095-4dannjjm 1137 8 important important JJ cord-023095-4dannjjm 1137 9 regulator regulator NN cord-023095-4dannjjm 1137 10 of of IN cord-023095-4dannjjm 1137 11 equine equine JJ cord-023095-4dannjjm 1137 12 neutrophil neutrophil NN cord-023095-4dannjjm 1137 13 chemotaxis chemotaxis NN cord-023095-4dannjjm 1137 14 and and CC cord-023095-4dannjjm 1137 15 represents represent VBZ cord-023095-4dannjjm 1137 16 a a DT cord-023095-4dannjjm 1137 17 potential potential JJ cord-023095-4dannjjm 1137 18 target target NN cord-023095-4dannjjm 1137 19 for for IN cord-023095-4dannjjm 1137 20 anti anti JJ cord-023095-4dannjjm 1137 21 - - JJ cord-023095-4dannjjm 1137 22 inflammatory inflammatory JJ cord-023095-4dannjjm 1137 23 therapy therapy NN cord-023095-4dannjjm 1137 24 . . . cord-023095-4dannjjm 1138 1 Amongst amongst IN cord-023095-4dannjjm 1138 2 other other JJ cord-023095-4dannjjm 1138 3 tests test NNS cord-023095-4dannjjm 1138 4 , , , cord-023095-4dannjjm 1138 5 a a DT cord-023095-4dannjjm 1138 6 thorough thorough JJ cord-023095-4dannjjm 1138 7 neurologic neurologic JJ cord-023095-4dannjjm 1138 8 examination examination NN cord-023095-4dannjjm 1138 9 of of IN cord-023095-4dannjjm 1138 10 horses horse NNS cord-023095-4dannjjm 1138 11 may may MD cord-023095-4dannjjm 1138 12 include include VB cord-023095-4dannjjm 1138 13 walking walk VBG cord-023095-4dannjjm 1138 14 with with IN cord-023095-4dannjjm 1138 15 the the DT cord-023095-4dannjjm 1138 16 head head NN cord-023095-4dannjjm 1138 17 elevated elevate VBN cord-023095-4dannjjm 1138 18 and and CC cord-023095-4dannjjm 1138 19 during during IN cord-023095-4dannjjm 1138 20 blindfolding blindfolding NN cord-023095-4dannjjm 1138 21 , , , cord-023095-4dannjjm 1138 22 in in IN cord-023095-4dannjjm 1138 23 order order NN cord-023095-4dannjjm 1138 24 to to TO cord-023095-4dannjjm 1138 25 help help VB cord-023095-4dannjjm 1138 26 differentiate differentiate VB cord-023095-4dannjjm 1138 27 normal normal JJ cord-023095-4dannjjm 1138 28 from from IN cord-023095-4dannjjm 1138 29 abnormal abnormal JJ cord-023095-4dannjjm 1138 30 and and CC cord-023095-4dannjjm 1138 31 to to TO cord-023095-4dannjjm 1138 32 help help VB cord-023095-4dannjjm 1138 33 with with IN cord-023095-4dannjjm 1138 34 neuroanatomically neuroanatomically RB cord-023095-4dannjjm 1138 35 localising localise VBG cord-023095-4dannjjm 1138 36 any any DT cord-023095-4dannjjm 1138 37 lesion(s lesion(s NNP cord-023095-4dannjjm 1138 38 ) ) -RRB- cord-023095-4dannjjm 1138 39 i.e. i.e. FW cord-023095-4dannjjm 1138 40 in in IN cord-023095-4dannjjm 1138 41 the the DT cord-023095-4dannjjm 1138 42 ataxic ataxic JJ cord-023095-4dannjjm 1138 43 horse horse NN cord-023095-4dannjjm 1138 44 . . . cord-023095-4dannjjm 1139 1 Consensus consensus NN cord-023095-4dannjjm 1139 2 amongst amongst IN cord-023095-4dannjjm 1139 3 equine equine JJ cord-023095-4dannjjm 1139 4 neurologists neurologist NNS cord-023095-4dannjjm 1139 5 suggests suggest VBZ cord-023095-4dannjjm 1139 6 that that IN cord-023095-4dannjjm 1139 7 gait gait JJ cord-023095-4dannjjm 1139 8 abnormalities abnormality NNS cord-023095-4dannjjm 1139 9 associated associate VBN cord-023095-4dannjjm 1139 10 with with IN cord-023095-4dannjjm 1139 11 these these DT cord-023095-4dannjjm 1139 12 specific specific JJ cord-023095-4dannjjm 1139 13 tests test NNS cord-023095-4dannjjm 1139 14 are be VBP cord-023095-4dannjjm 1139 15 often often RB cord-023095-4dannjjm 1139 16 exacerbated exacerbate VBN cord-023095-4dannjjm 1139 17 in in IN cord-023095-4dannjjm 1139 18 horses horse NNS cord-023095-4dannjjm 1139 19 with with IN cord-023095-4dannjjm 1139 20 underlying underlying JJ cord-023095-4dannjjm 1139 21 proprioceptive proprioceptive JJ cord-023095-4dannjjm 1139 22 deficits deficit NNS cord-023095-4dannjjm 1139 23 however however RB cord-023095-4dannjjm 1139 24 the the DT cord-023095-4dannjjm 1139 25 effect effect NN cord-023095-4dannjjm 1139 26 of of IN cord-023095-4dannjjm 1139 27 these these DT cord-023095-4dannjjm 1139 28 tests test NNS cord-023095-4dannjjm 1139 29 on on IN cord-023095-4dannjjm 1139 30 temporal temporal JJ cord-023095-4dannjjm 1139 31 gait gait JJ cord-023095-4dannjjm 1139 32 characteristics characteristic NNS cord-023095-4dannjjm 1139 33 in in IN cord-023095-4dannjjm 1139 34 normal normal JJ cord-023095-4dannjjm 1139 35 horses horse NNS cord-023095-4dannjjm 1139 36 has have VBZ cord-023095-4dannjjm 1139 37 not not RB cord-023095-4dannjjm 1139 38 previously previously RB cord-023095-4dannjjm 1139 39 been be VBN cord-023095-4dannjjm 1139 40 assessed assess VBN cord-023095-4dannjjm 1139 41 quantitatively quantitatively RB cord-023095-4dannjjm 1139 42 . . . cord-023095-4dannjjm 1140 1 We -PRON- PRP cord-023095-4dannjjm 1140 2 hypothesized hypothesize VBD cord-023095-4dannjjm 1140 3 that that IN cord-023095-4dannjjm 1140 4 head head NN cord-023095-4dannjjm 1140 5 elevation elevation NN cord-023095-4dannjjm 1140 6 or or CC cord-023095-4dannjjm 1140 7 blindfolding blindfolding NN cord-023095-4dannjjm 1140 8 , , , cord-023095-4dannjjm 1140 9 in in IN cord-023095-4dannjjm 1140 10 comparison comparison NN cord-023095-4dannjjm 1140 11 with with IN cord-023095-4dannjjm 1140 12 walking walk VBG cord-023095-4dannjjm 1140 13 in in IN cord-023095-4dannjjm 1140 14 a a DT cord-023095-4dannjjm 1140 15 straight straight JJ cord-023095-4dannjjm 1140 16 line line NN cord-023095-4dannjjm 1140 17 would would MD cord-023095-4dannjjm 1140 18 result result VB cord-023095-4dannjjm 1140 19 in in IN cord-023095-4dannjjm 1140 20 a a DT cord-023095-4dannjjm 1140 21 compensatory compensatory JJ cord-023095-4dannjjm 1140 22 decrease decrease NN cord-023095-4dannjjm 1140 23 in in IN cord-023095-4dannjjm 1140 24 lateral lateral JJ cord-023095-4dannjjm 1140 25 ( ( -LRB- cord-023095-4dannjjm 1140 26 left left JJ cord-023095-4dannjjm 1140 27 front front NN cord-023095-4dannjjm 1140 28 - - HYPH cord-023095-4dannjjm 1140 29 on on RP cord-023095-4dannjjm 1140 30 to to IN cord-023095-4dannjjm 1140 31 left left JJ cord-023095-4dannjjm 1140 32 hind hind NN cord-023095-4dannjjm 1140 33 - - HYPH cord-023095-4dannjjm 1140 34 on on JJ cord-023095-4dannjjm 1140 35 and and CC cord-023095-4dannjjm 1140 36 right right JJ cord-023095-4dannjjm 1140 37 front front NN cord-023095-4dannjjm 1140 38 - - HYPH cord-023095-4dannjjm 1140 39 on on NN cord-023095-4dannjjm 1140 40 to to IN cord-023095-4dannjjm 1140 41 right right JJ cord-023095-4dannjjm 1140 42 hind hind NN cord-023095-4dannjjm 1140 43 - - HYPH cord-023095-4dannjjm 1140 44 on on RP cord-023095-4dannjjm 1140 45 ) ) -RRB- cord-023095-4dannjjm 1140 46 and and CC cord-023095-4dannjjm 1140 47 diagonal diagonal JJ cord-023095-4dannjjm 1140 48 coupling coupling NN cord-023095-4dannjjm 1140 49 intervals interval NNS cord-023095-4dannjjm 1140 50 ( ( -LRB- cord-023095-4dannjjm 1140 51 left leave VBN cord-023095-4dannjjm 1140 52 front front NN cord-023095-4dannjjm 1140 53 - - HYPH cord-023095-4dannjjm 1140 54 on on NN cord-023095-4dannjjm 1140 55 to to IN cord-023095-4dannjjm 1140 56 right right JJ cord-023095-4dannjjm 1140 57 hind hind NN cord-023095-4dannjjm 1140 58 - - HYPH cord-023095-4dannjjm 1140 59 on on JJ cord-023095-4dannjjm 1140 60 and and CC cord-023095-4dannjjm 1140 61 right right JJ cord-023095-4dannjjm 1140 62 front front NN cord-023095-4dannjjm 1140 63 - - HYPH cord-023095-4dannjjm 1140 64 on on RP cord-023095-4dannjjm 1140 65 to to IN cord-023095-4dannjjm 1140 66 left left JJ cord-023095-4dannjjm 1140 67 hind hind NN cord-023095-4dannjjm 1140 68 - - HYPH cord-023095-4dannjjm 1140 69 on on IN cord-023095-4dannjjm 1140 70 ) ) -RRB- cord-023095-4dannjjm 1140 71 in in IN cord-023095-4dannjjm 1140 72 normal normal JJ cord-023095-4dannjjm 1140 73 horses horse NNS cord-023095-4dannjjm 1140 74 . . . cord-023095-4dannjjm 1141 1 Four four CD cord-023095-4dannjjm 1141 2 Thoroughbreds thoroughbred NNS cord-023095-4dannjjm 1141 3 without without IN cord-023095-4dannjjm 1141 4 any any DT cord-023095-4dannjjm 1141 5 history history NN cord-023095-4dannjjm 1141 6 or or CC cord-023095-4dannjjm 1141 7 clinical clinical JJ cord-023095-4dannjjm 1141 8 signs sign NNS cord-023095-4dannjjm 1141 9 suggestive suggestive JJ cord-023095-4dannjjm 1141 10 of of IN cord-023095-4dannjjm 1141 11 neurological neurological JJ cord-023095-4dannjjm 1141 12 disease disease NN cord-023095-4dannjjm 1141 13 ( ( -LRB- cord-023095-4dannjjm 1141 14 age age NN cord-023095-4dannjjm 1141 15 range range NN cord-023095-4dannjjm 1141 16 3 3 CD cord-023095-4dannjjm 1141 17 to to TO cord-023095-4dannjjm 1141 18 5 5 CD cord-023095-4dannjjm 1141 19 years year NNS cord-023095-4dannjjm 1141 20 ) ) -RRB- cord-023095-4dannjjm 1141 21 were be VBD cord-023095-4dannjjm 1141 22 included include VBN cord-023095-4dannjjm 1141 23 in in IN cord-023095-4dannjjm 1141 24 the the DT cord-023095-4dannjjm 1141 25 study study NN cord-023095-4dannjjm 1141 26 . . . cord-023095-4dannjjm 1142 1 Retroreflective retroreflective JJ cord-023095-4dannjjm 1142 2 markers marker NNS cord-023095-4dannjjm 1142 3 were be VBD cord-023095-4dannjjm 1142 4 applied apply VBN cord-023095-4dannjjm 1142 5 to to IN cord-023095-4dannjjm 1142 6 the the DT cord-023095-4dannjjm 1142 7 withers withers NN cord-023095-4dannjjm 1142 8 , , , cord-023095-4dannjjm 1142 9 to to IN cord-023095-4dannjjm 1142 10 the the DT cord-023095-4dannjjm 1142 11 sacrum sacrum NN cord-023095-4dannjjm 1142 12 and and CC cord-023095-4dannjjm 1142 13 to to TO cord-023095-4dannjjm 1142 14 left left VB cord-023095-4dannjjm 1142 15 and and CC cord-023095-4dannjjm 1142 16 right right JJ cord-023095-4dannjjm 1142 17 tuber tuber NN cord-023095-4dannjjm 1142 18 coxae coxae NN cord-023095-4dannjjm 1142 19 ; ; : cord-023095-4dannjjm 1142 20 for for IN cord-023095-4dannjjm 1142 21 each each DT cord-023095-4dannjjm 1142 22 limb limb NN cord-023095-4dannjjm 1142 23 , , , cord-023095-4dannjjm 1142 24 lateral lateral JJ cord-023095-4dannjjm 1142 25 fetlock fetlock NN cord-023095-4dannjjm 1142 26 markers marker NNS cord-023095-4dannjjm 1142 27 and and CC cord-023095-4dannjjm 1142 28 dorsal dorsal JJ cord-023095-4dannjjm 1142 29 and and CC cord-023095-4dannjjm 1142 30 lateral lateral JJ cord-023095-4dannjjm 1142 31 hoof hoof NN cord-023095-4dannjjm 1142 32 wall wall NN cord-023095-4dannjjm 1142 33 markers marker NNS cord-023095-4dannjjm 1142 34 were be VBD cord-023095-4dannjjm 1142 35 used use VBN cord-023095-4dannjjm 1142 36 . . . cord-023095-4dannjjm 1143 1 A a DT cord-023095-4dannjjm 1143 2 minimum minimum NN cord-023095-4dannjjm 1143 3 of of IN cord-023095-4dannjjm 1143 4 3 3 CD cord-023095-4dannjjm 1143 5 trials trial NNS cord-023095-4dannjjm 1143 6 each each DT cord-023095-4dannjjm 1143 7 with with IN cord-023095-4dannjjm 1143 8 2 2 CD cord-023095-4dannjjm 1143 9 - - SYM cord-023095-4dannjjm 1143 10 4 4 CD cord-023095-4dannjjm 1143 11 walk walk NN cord-023095-4dannjjm 1143 12 strides stride NNS cord-023095-4dannjjm 1143 13 for for IN cord-023095-4dannjjm 1143 14 each each DT cord-023095-4dannjjm 1143 15 task task NN cord-023095-4dannjjm 1143 16 were be VBD cord-023095-4dannjjm 1143 17 analysed analyse VBN cord-023095-4dannjjm 1143 18 as as IN cord-023095-4dannjjm 1143 19 horses horse NNS cord-023095-4dannjjm 1143 20 walked walk VBD cord-023095-4dannjjm 1143 21 across across IN cord-023095-4dannjjm 1143 22 an an DT cord-023095-4dannjjm 1143 23 8-force 8-force CD cord-023095-4dannjjm 1143 24 - - HYPH cord-023095-4dannjjm 1143 25 plate plate NN cord-023095-4dannjjm 1143 26 runway runway NN cord-023095-4dannjjm 1143 27 i i PRP cord-023095-4dannjjm 1143 28 surrounded surround VBD cord-023095-4dannjjm 1143 29 by by IN cord-023095-4dannjjm 1143 30 a a DT cord-023095-4dannjjm 1143 31 12-camera 12-camera CD cord-023095-4dannjjm 1143 32 kinematic kinematic JJ cord-023095-4dannjjm 1143 33 system system NN cord-023095-4dannjjm 1143 34 . . . cord-023095-4dannjjm 1144 1 ii ii NNP cord-023095-4dannjjm 1144 2 Force Force NNP cord-023095-4dannjjm 1144 3 - - HYPH cord-023095-4dannjjm 1144 4 plate plate NN cord-023095-4dannjjm 1144 5 data datum NNS cord-023095-4dannjjm 1144 6 were be VBD cord-023095-4dannjjm 1144 7 processed process VBN cord-023095-4dannjjm 1144 8 with with IN cord-023095-4dannjjm 1144 9 semi semi JJ cord-023095-4dannjjm 1144 10 - - JJ cord-023095-4dannjjm 1144 11 automated automated JJ cord-023095-4dannjjm 1144 12 custom custom NN cord-023095-4dannjjm 1144 13 written write VBN cord-023095-4dannjjm 1144 14 Matlab Matlab NNP cord-023095-4dannjjm 1144 15 iii iii NNP cord-023095-4dannjjm 1144 16 scripts script NNS cord-023095-4dannjjm 1144 17 . . . cord-023095-4dannjjm 1145 1 Data datum NNS cord-023095-4dannjjm 1145 2 were be VBD cord-023095-4dannjjm 1145 3 analysed analyse VBN cord-023095-4dannjjm 1145 4 with with IN cord-023095-4dannjjm 1145 5 a a DT cord-023095-4dannjjm 1145 6 mixed mixed JJ cord-023095-4dannjjm 1145 7 model model NN cord-023095-4dannjjm 1145 8 using use VBG cord-023095-4dannjjm 1145 9 the the DT cord-023095-4dannjjm 1145 10 statistical statistical JJ cord-023095-4dannjjm 1145 11 software software NN cord-023095-4dannjjm 1145 12 R. R. NNP cord-023095-4dannjjm 1146 1 There there EX cord-023095-4dannjjm 1146 2 was be VBD cord-023095-4dannjjm 1146 3 a a DT cord-023095-4dannjjm 1146 4 significant significant JJ cord-023095-4dannjjm 1146 5 fixed fix VBN cord-023095-4dannjjm 1146 6 effect effect NN cord-023095-4dannjjm 1146 7 of of IN cord-023095-4dannjjm 1146 8 normal normal JJ cord-023095-4dannjjm 1146 9 walk walk NN cord-023095-4dannjjm 1146 10 on on IN cord-023095-4dannjjm 1146 11 a a DT cord-023095-4dannjjm 1146 12 straight straight JJ cord-023095-4dannjjm 1146 13 line line NN cord-023095-4dannjjm 1146 14 and and CC cord-023095-4dannjjm 1146 15 head head NN cord-023095-4dannjjm 1146 16 elevation elevation NN cord-023095-4dannjjm 1146 17 on on IN cord-023095-4dannjjm 1146 18 left left JJ cord-023095-4dannjjm 1146 19 and and CC cord-023095-4dannjjm 1146 20 right right JJ cord-023095-4dannjjm 1146 21 lateral lateral JJ cord-023095-4dannjjm 1146 22 coupling coupling NN cord-023095-4dannjjm 1146 23 intervals interval NNS cord-023095-4dannjjm 1146 24 ( ( -LRB- cord-023095-4dannjjm 1146 25 p p NN cord-023095-4dannjjm 1146 26 o o NN cord-023095-4dannjjm 1146 27 0.0001 0.0001 CD cord-023095-4dannjjm 1146 28 ) ) -RRB- cord-023095-4dannjjm 1146 29 and and CC cord-023095-4dannjjm 1146 30 of of IN cord-023095-4dannjjm 1146 31 the the DT cord-023095-4dannjjm 1146 32 left left JJ cord-023095-4dannjjm 1146 33 and and CC cord-023095-4dannjjm 1146 34 right right JJ cord-023095-4dannjjm 1146 35 diagonal diagonal JJ cord-023095-4dannjjm 1146 36 coupling coupling NN cord-023095-4dannjjm 1146 37 intervals interval NNS cord-023095-4dannjjm 1146 38 ( ( -LRB- cord-023095-4dannjjm 1146 39 p p NN cord-023095-4dannjjm 1146 40 o o NN cord-023095-4dannjjm 1146 41 0.0001 0.0001 CD cord-023095-4dannjjm 1146 42 ) ) -RRB- cord-023095-4dannjjm 1146 43 . . . cord-023095-4dannjjm 1147 1 There there EX cord-023095-4dannjjm 1147 2 was be VBD cord-023095-4dannjjm 1147 3 no no DT cord-023095-4dannjjm 1147 4 significant significant JJ cord-023095-4dannjjm 1147 5 effect effect NN cord-023095-4dannjjm 1147 6 of of IN cord-023095-4dannjjm 1147 7 blindfolding blindfold VBG cord-023095-4dannjjm 1147 8 on on IN cord-023095-4dannjjm 1147 9 neither neither DT cord-023095-4dannjjm 1147 10 lateral lateral JJ cord-023095-4dannjjm 1147 11 nor nor CC cord-023095-4dannjjm 1147 12 diagonal diagonal JJ cord-023095-4dannjjm 1147 13 coupling coupling NN cord-023095-4dannjjm 1147 14 intervals interval NNS cord-023095-4dannjjm 1147 15 . . . cord-023095-4dannjjm 1148 1 The the DT cord-023095-4dannjjm 1148 2 random random JJ cord-023095-4dannjjm 1148 3 effect effect NN cord-023095-4dannjjm 1148 4 of of IN cord-023095-4dannjjm 1148 5 horse horse NN cord-023095-4dannjjm 1148 6 had have VBD cord-023095-4dannjjm 1148 7 no no DT cord-023095-4dannjjm 1148 8 influence influence NN cord-023095-4dannjjm 1148 9 on on IN cord-023095-4dannjjm 1148 10 the the DT cord-023095-4dannjjm 1148 11 coupling coupling NN cord-023095-4dannjjm 1148 12 intervals interval NNS cord-023095-4dannjjm 1148 13 . . . cord-023095-4dannjjm 1149 1 The the DT cord-023095-4dannjjm 1149 2 decrease decrease NN cord-023095-4dannjjm 1149 3 of of IN cord-023095-4dannjjm 1149 4 the the DT cord-023095-4dannjjm 1149 5 lateral lateral JJ cord-023095-4dannjjm 1149 6 coupling coupling NN cord-023095-4dannjjm 1149 7 intervals interval NNS cord-023095-4dannjjm 1149 8 indicates indicate VBZ cord-023095-4dannjjm 1149 9 a a DT cord-023095-4dannjjm 1149 10 tendency tendency NN cord-023095-4dannjjm 1149 11 towards towards IN cord-023095-4dannjjm 1149 12 a a DT cord-023095-4dannjjm 1149 13 pacing pace VBG cord-023095-4dannjjm 1149 14 gait gait NN cord-023095-4dannjjm 1149 15 during during IN cord-023095-4dannjjm 1149 16 head head NN cord-023095-4dannjjm 1149 17 elevation elevation NN cord-023095-4dannjjm 1149 18 . . . cord-023095-4dannjjm 1150 1 We -PRON- PRP cord-023095-4dannjjm 1150 2 conclude conclude VBP cord-023095-4dannjjm 1150 3 that that IN cord-023095-4dannjjm 1150 4 there there EX cord-023095-4dannjjm 1150 5 is be VBZ cord-023095-4dannjjm 1150 6 a a DT cord-023095-4dannjjm 1150 7 significant significant JJ cord-023095-4dannjjm 1150 8 change change NN cord-023095-4dannjjm 1150 9 in in IN cord-023095-4dannjjm 1150 10 temporal temporal JJ cord-023095-4dannjjm 1150 11 gait gait JJ cord-023095-4dannjjm 1150 12 characteristics characteristic NNS cord-023095-4dannjjm 1150 13 of of IN cord-023095-4dannjjm 1150 14 non non JJ cord-023095-4dannjjm 1150 15 - - JJ cord-023095-4dannjjm 1150 16 neurologic neurologic JJ cord-023095-4dannjjm 1150 17 horses horse NNS cord-023095-4dannjjm 1150 18 when when WRB cord-023095-4dannjjm 1150 19 the the DT cord-023095-4dannjjm 1150 20 head head NN cord-023095-4dannjjm 1150 21 is be VBZ cord-023095-4dannjjm 1150 22 elevated elevate VBN cord-023095-4dannjjm 1150 23 but but CC cord-023095-4dannjjm 1150 24 not not RB cord-023095-4dannjjm 1150 25 during during IN cord-023095-4dannjjm 1150 26 blindfolding blindfold VBG cord-023095-4dannjjm 1150 27 compared compare VBN cord-023095-4dannjjm 1150 28 to to IN cord-023095-4dannjjm 1150 29 normal normal JJ cord-023095-4dannjjm 1150 30 walking walking NN cord-023095-4dannjjm 1150 31 . . . cord-023095-4dannjjm 1151 1 Current current JJ cord-023095-4dannjjm 1151 2 results result NNS cord-023095-4dannjjm 1151 3 suggest suggest VBP cord-023095-4dannjjm 1151 4 that that IN cord-023095-4dannjjm 1151 5 pacing pace VBG cord-023095-4dannjjm 1151 6 and and CC cord-023095-4dannjjm 1151 7 increased increase VBN cord-023095-4dannjjm 1151 8 variation variation NN cord-023095-4dannjjm 1151 9 in in IN cord-023095-4dannjjm 1151 10 foot foot NN cord-023095-4dannjjm 1151 11 - - HYPH cord-023095-4dannjjm 1151 12 placement placement NN cord-023095-4dannjjm 1151 13 during during IN cord-023095-4dannjjm 1151 14 head head NN cord-023095-4dannjjm 1151 15 elevation elevation NN cord-023095-4dannjjm 1151 16 should should MD cord-023095-4dannjjm 1151 17 be be VB cord-023095-4dannjjm 1151 18 interpreted interpret VBN cord-023095-4dannjjm 1151 19 with with IN cord-023095-4dannjjm 1151 20 caution caution NN cord-023095-4dannjjm 1151 21 however however RB cord-023095-4dannjjm 1151 22 further further JJ cord-023095-4dannjjm 1151 23 work work NN cord-023095-4dannjjm 1151 24 is be VBZ cord-023095-4dannjjm 1151 25 required require VBN cord-023095-4dannjjm 1151 26 to to TO cord-023095-4dannjjm 1151 27 determine determine VB cord-023095-4dannjjm 1151 28 whether whether IN cord-023095-4dannjjm 1151 29 the the DT cord-023095-4dannjjm 1151 30 change change NN cord-023095-4dannjjm 1151 31 differs differ VBZ cord-023095-4dannjjm 1151 32 between between IN cord-023095-4dannjjm 1151 33 horses horse NNS cord-023095-4dannjjm 1151 34 with with IN cord-023095-4dannjjm 1151 35 neurological neurological JJ cord-023095-4dannjjm 1151 36 disease disease NN cord-023095-4dannjjm 1151 37 and and CC cord-023095-4dannjjm 1151 38 non non JJ cord-023095-4dannjjm 1151 39 - - JJ cord-023095-4dannjjm 1151 40 neurologic neurologic JJ cord-023095-4dannjjm 1151 41 disease disease NN cord-023095-4dannjjm 1151 42 . . . cord-023095-4dannjjm 1152 1 Hereditary hereditary JJ cord-023095-4dannjjm 1152 2 Equine Equine NNP cord-023095-4dannjjm 1152 3 Regional Regional NNP cord-023095-4dannjjm 1152 4 Dermal Dermal NNP cord-023095-4dannjjm 1152 5 Asthenia Asthenia NNP cord-023095-4dannjjm 1152 6 ( ( -LRB- cord-023095-4dannjjm 1152 7 HERDA HERDA NNP cord-023095-4dannjjm 1152 8 ) ) -RRB- cord-023095-4dannjjm 1152 9 is be VBZ cord-023095-4dannjjm 1152 10 an an DT cord-023095-4dannjjm 1152 11 autosomal autosomal JJ cord-023095-4dannjjm 1152 12 recessive recessive JJ cord-023095-4dannjjm 1152 13 connective connective JJ cord-023095-4dannjjm 1152 14 tissue tissue NN cord-023095-4dannjjm 1152 15 disorder disorder NN cord-023095-4dannjjm 1152 16 associated associate VBN cord-023095-4dannjjm 1152 17 with with IN cord-023095-4dannjjm 1152 18 a a DT cord-023095-4dannjjm 1152 19 mutation mutation NN cord-023095-4dannjjm 1152 20 in in IN cord-023095-4dannjjm 1152 21 cyclophillin cyclophillin NNP cord-023095-4dannjjm 1152 22 B B NNP cord-023095-4dannjjm 1152 23 that that WDT cord-023095-4dannjjm 1152 24 leads lead VBZ cord-023095-4dannjjm 1152 25 to to IN cord-023095-4dannjjm 1152 26 impaired impaired JJ cord-023095-4dannjjm 1152 27 collagen collagen NN cord-023095-4dannjjm 1152 28 folding folding NN cord-023095-4dannjjm 1152 29 , , , cord-023095-4dannjjm 1152 30 aberrant aberrant JJ cord-023095-4dannjjm 1152 31 wound wound NN cord-023095-4dannjjm 1152 32 repair repair NN cord-023095-4dannjjm 1152 33 , , , cord-023095-4dannjjm 1152 34 and and CC cord-023095-4dannjjm 1152 35 corneal corneal JJ cord-023095-4dannjjm 1152 36 abnormalities abnormality NNS cord-023095-4dannjjm 1152 37 . . . cord-023095-4dannjjm 1153 1 It -PRON- PRP cord-023095-4dannjjm 1153 2 affects affect VBZ cord-023095-4dannjjm 1153 3 young young JJ cord-023095-4dannjjm 1153 4 Quarter Quarter NNP cord-023095-4dannjjm 1153 5 Horses Horses NNPS cord-023095-4dannjjm 1153 6 , , , cord-023095-4dannjjm 1153 7 Appaloosa Appaloosa NNP cord-023095-4dannjjm 1153 8 , , , cord-023095-4dannjjm 1153 9 and and CC cord-023095-4dannjjm 1153 10 Paints paint NNS cord-023095-4dannjjm 1153 11 . . . cord-023095-4dannjjm 1154 1 HERDA HERDA NNP cord-023095-4dannjjm 1154 2 shows show VBZ cord-023095-4dannjjm 1154 3 similarities similarity NNS cord-023095-4dannjjm 1154 4 to to IN cord-023095-4dannjjm 1154 5 the the DT cord-023095-4dannjjm 1154 6 human human JJ cord-023095-4dannjjm 1154 7 hereditary hereditary JJ cord-023095-4dannjjm 1154 8 connective connective JJ cord-023095-4dannjjm 1154 9 tissue tissue NN cord-023095-4dannjjm 1154 10 syndrome syndrome NN cord-023095-4dannjjm 1154 11 Ehlers Ehlers NNP cord-023095-4dannjjm 1154 12 Danlos Danlos NNP cord-023095-4dannjjm 1154 13 ( ( -LRB- cord-023095-4dannjjm 1154 14 EDS EDS NNP cord-023095-4dannjjm 1154 15 ) ) -RRB- cord-023095-4dannjjm 1154 16 . . . cord-023095-4dannjjm 1155 1 Many many JJ cord-023095-4dannjjm 1155 2 EDS EDS NNP cord-023095-4dannjjm 1155 3 patients patient NNS cord-023095-4dannjjm 1155 4 suffer suffer VBP cord-023095-4dannjjm 1155 5 from from IN cord-023095-4dannjjm 1155 6 joint joint JJ cord-023095-4dannjjm 1155 7 pain pain NN cord-023095-4dannjjm 1155 8 and and CC cord-023095-4dannjjm 1155 9 osteoarthritis osteoarthritis NN cord-023095-4dannjjm 1155 10 ( ( -LRB- cord-023095-4dannjjm 1155 11 OA OA NNP cord-023095-4dannjjm 1155 12 ) ) -RRB- cord-023095-4dannjjm 1155 13 as as IN cord-023095-4dannjjm 1155 14 adults adult NNS cord-023095-4dannjjm 1155 15 . . . cord-023095-4dannjjm 1156 1 The the DT cord-023095-4dannjjm 1156 2 similarity similarity NN cord-023095-4dannjjm 1156 3 between between IN cord-023095-4dannjjm 1156 4 EDS EDS NNP cord-023095-4dannjjm 1156 5 and and CC cord-023095-4dannjjm 1156 6 HERDA HERDA NNP cord-023095-4dannjjm 1156 7 raises raise VBZ cord-023095-4dannjjm 1156 8 the the DT cord-023095-4dannjjm 1156 9 question question NN cord-023095-4dannjjm 1156 10 whether whether IN cord-023095-4dannjjm 1156 11 horses horse NNS cord-023095-4dannjjm 1156 12 suffering suffer VBG cord-023095-4dannjjm 1156 13 from from IN cord-023095-4dannjjm 1156 14 HERDA HERDA NNP cord-023095-4dannjjm 1156 15 develop develop VBP cord-023095-4dannjjm 1156 16 OA OA NNP cord-023095-4dannjjm 1156 17 . . . cord-023095-4dannjjm 1157 1 In in IN cord-023095-4dannjjm 1157 2 OA OA NNP cord-023095-4dannjjm 1157 3 , , , cord-023095-4dannjjm 1157 4 excess excess JJ cord-023095-4dannjjm 1157 5 production production NN cord-023095-4dannjjm 1157 6 of of IN cord-023095-4dannjjm 1157 7 inflammatory inflammatory JJ cord-023095-4dannjjm 1157 8 mediators mediator NNS cord-023095-4dannjjm 1157 9 such such JJ cord-023095-4dannjjm 1157 10 as as IN cord-023095-4dannjjm 1157 11 prostaglandin prostaglandin NN cord-023095-4dannjjm 1157 12 E2 e2 NN cord-023095-4dannjjm 1157 13 ( ( -LRB- cord-023095-4dannjjm 1157 14 PGE PGE NNP cord-023095-4dannjjm 1157 15 2 2 CD cord-023095-4dannjjm 1157 16 ) ) -RRB- cord-023095-4dannjjm 1157 17 activate activate VBP cord-023095-4dannjjm 1157 18 enzymes enzyme NNS cord-023095-4dannjjm 1157 19 that that WDT cord-023095-4dannjjm 1157 20 degrade degrade VBP cord-023095-4dannjjm 1157 21 cartilage cartilage NN cord-023095-4dannjjm 1157 22 as as RB cord-023095-4dannjjm 1157 23 well well RB cord-023095-4dannjjm 1157 24 as as IN cord-023095-4dannjjm 1157 25 impede impede NNS cord-023095-4dannjjm 1157 26 wound wind VBN cord-023095-4dannjjm 1157 27 healing healing NN cord-023095-4dannjjm 1157 28 . . . cord-023095-4dannjjm 1158 1 The the DT cord-023095-4dannjjm 1158 2 present present JJ cord-023095-4dannjjm 1158 3 study study NN cord-023095-4dannjjm 1158 4 examined examine VBD cord-023095-4dannjjm 1158 5 articular articular JJ cord-023095-4dannjjm 1158 6 cartilage cartilage NN cord-023095-4dannjjm 1158 7 from from IN cord-023095-4dannjjm 1158 8 yearling yearling JJ cord-023095-4dannjjm 1158 9 horses horse NNS cord-023095-4dannjjm 1158 10 afflicted afflict VBN cord-023095-4dannjjm 1158 11 with with IN cord-023095-4dannjjm 1158 12 HERDA HERDA NNP cord-023095-4dannjjm 1158 13 . . . cord-023095-4dannjjm 1159 1 We -PRON- PRP cord-023095-4dannjjm 1159 2 hypothesized hypothesize VBD cord-023095-4dannjjm 1159 3 that that IN cord-023095-4dannjjm 1159 4 chondrocytes chondrocyte NNS cord-023095-4dannjjm 1159 5 from from IN cord-023095-4dannjjm 1159 6 these these DT cord-023095-4dannjjm 1159 7 horses horse NNS cord-023095-4dannjjm 1159 8 are be VBP cord-023095-4dannjjm 1159 9 continually continually RB cord-023095-4dannjjm 1159 10 activated activate VBN cord-023095-4dannjjm 1159 11 to to TO cord-023095-4dannjjm 1159 12 produce produce VB cord-023095-4dannjjm 1159 13 inflammatory inflammatory JJ cord-023095-4dannjjm 1159 14 mediators mediator NNS cord-023095-4dannjjm 1159 15 . . . cord-023095-4dannjjm 1160 1 To to TO cord-023095-4dannjjm 1160 2 test test VB cord-023095-4dannjjm 1160 3 this this DT cord-023095-4dannjjm 1160 4 hypothesis hypothesis NN cord-023095-4dannjjm 1160 5 , , , cord-023095-4dannjjm 1160 6 articular articular JJ cord-023095-4dannjjm 1160 7 cartilage cartilage NN cord-023095-4dannjjm 1160 8 from from IN cord-023095-4dannjjm 1160 9 carpal carpal NN cord-023095-4dannjjm 1160 10 and and CC cord-023095-4dannjjm 1160 11 tarsal tarsal NN cord-023095-4dannjjm 1160 12 joints joint NNS cord-023095-4dannjjm 1160 13 of of IN cord-023095-4dannjjm 1160 14 HERDA HERDA NNP cord-023095-4dannjjm 1160 15 horses horse NNS cord-023095-4dannjjm 1160 16 were be VBD cord-023095-4dannjjm 1160 17 evaluated evaluate VBN cord-023095-4dannjjm 1160 18 using use VBG cord-023095-4dannjjm 1160 19 histology histology NN cord-023095-4dannjjm 1160 20 . . . cord-023095-4dannjjm 1161 1 PGE PGE NNP cord-023095-4dannjjm 1161 2 2 2 CD cord-023095-4dannjjm 1161 3 production production NN cord-023095-4dannjjm 1161 4 by by IN cord-023095-4dannjjm 1161 5 chondrocyte chondrocyte NNP cord-023095-4dannjjm 1161 6 cultures culture NNS cord-023095-4dannjjm 1161 7 was be VBD cord-023095-4dannjjm 1161 8 measured measure VBN cord-023095-4dannjjm 1161 9 by by IN cord-023095-4dannjjm 1161 10 ELISA ELISA NNP cord-023095-4dannjjm 1161 11 and and CC cord-023095-4dannjjm 1161 12 analyzed analyze VBN cord-023095-4dannjjm 1161 13 by by IN cord-023095-4dannjjm 1161 14 one one CD cord-023095-4dannjjm 1161 15 - - HYPH cord-023095-4dannjjm 1161 16 way way NN cord-023095-4dannjjm 1161 17 ANOVA anova NN cord-023095-4dannjjm 1161 18 , , , cord-023095-4dannjjm 1161 19 Tukey Tukey NNP cord-023095-4dannjjm 1161 20 post post NN cord-023095-4dannjjm 1161 21 - - JJ cord-023095-4dannjjm 1161 22 hoc hoc JJ cord-023095-4dannjjm 1161 23 test test NN cord-023095-4dannjjm 1161 24 , , , cord-023095-4dannjjm 1161 25 p p NN cord-023095-4dannjjm 1161 26 o o NN cord-023095-4dannjjm 1161 27 0.05 0.05 CD cord-023095-4dannjjm 1161 28 significance significance NN cord-023095-4dannjjm 1161 29 . . . cord-023095-4dannjjm 1162 1 We -PRON- PRP cord-023095-4dannjjm 1162 2 also also RB cord-023095-4dannjjm 1162 3 determined determine VBD cord-023095-4dannjjm 1162 4 the the DT cord-023095-4dannjjm 1162 5 antiinflammatory antiinflammatory JJ cord-023095-4dannjjm 1162 6 effects effect NNS cord-023095-4dannjjm 1162 7 of of IN cord-023095-4dannjjm 1162 8 an an DT cord-023095-4dannjjm 1162 9 avocado avocado NN cord-023095-4dannjjm 1162 10 / / SYM cord-023095-4dannjjm 1162 11 soybean soybean NN cord-023095-4dannjjm 1162 12 unsaponifiables unsaponifiable NNS cord-023095-4dannjjm 1162 13 ( ( -LRB- cord-023095-4dannjjm 1162 14 ASU ASU NNP cord-023095-4dannjjm 1162 15 ) ) -RRB- cord-023095-4dannjjm 1162 16 , , , cord-023095-4dannjjm 1162 17 glucosamine glucosamine FW cord-023095-4dannjjm 1162 18 ( ( -LRB- cord-023095-4dannjjm 1162 19 GLU GLU NNP cord-023095-4dannjjm 1162 20 ) ) -RRB- cord-023095-4dannjjm 1162 21 , , , cord-023095-4dannjjm 1162 22 and and CC cord-023095-4dannjjm 1162 23 chondroitin chondroitin NN cord-023095-4dannjjm 1162 24 sulfate sulfate NN cord-023095-4dannjjm 1162 25 ( ( -LRB- cord-023095-4dannjjm 1162 26 CS CS NNP cord-023095-4dannjjm 1162 27 ) ) -RRB- cord-023095-4dannjjm 1162 28 mixture mixture NN cord-023095-4dannjjm 1162 29 ( ( -LRB- cord-023095-4dannjjm 1162 30 ingredients ingredient NNS cord-023095-4dannjjm 1162 31 found find VBN cord-023095-4dannjjm 1162 32 in in IN cord-023095-4dannjjm 1162 33 Cosequin Cosequin NNP cord-023095-4dannjjm 1162 34 s s POS cord-023095-4dannjjm 1162 35 ASU ASU NNP cord-023095-4dannjjm 1162 36 ) ) -RRB- cord-023095-4dannjjm 1162 37 and and CC cord-023095-4dannjjm 1162 38 phenylbutazone phenylbutazone NNP cord-023095-4dannjjm 1162 39 ( ( -LRB- cord-023095-4dannjjm 1162 40 PBZ PBZ NNP cord-023095-4dannjjm 1162 41 ) ) -RRB- cord-023095-4dannjjm 1162 42 on on IN cord-023095-4dannjjm 1162 43 chondrocytes chondrocyte NNS cord-023095-4dannjjm 1162 44 . . . cord-023095-4dannjjm 1163 1 Cosequin Cosequin NNP cord-023095-4dannjjm 1163 2 s s POS cord-023095-4dannjjm 1163 3 ASU ASU NNP cord-023095-4dannjjm 1163 4 and and CC cord-023095-4dannjjm 1163 5 PBZ PBZ NNP cord-023095-4dannjjm 1163 6 are be VBP cord-023095-4dannjjm 1163 7 used use VBN cord-023095-4dannjjm 1163 8 alone alone RB cord-023095-4dannjjm 1163 9 or or CC cord-023095-4dannjjm 1163 10 in in IN cord-023095-4dannjjm 1163 11 combination combination NN cord-023095-4dannjjm 1163 12 for for IN cord-023095-4dannjjm 1163 13 the the DT cord-023095-4dannjjm 1163 14 management management NN cord-023095-4dannjjm 1163 15 of of IN cord-023095-4dannjjm 1163 16 OA OA NNP cord-023095-4dannjjm 1163 17 . . . cord-023095-4dannjjm 1164 1 Chondrocyte Chondrocyte NNP cord-023095-4dannjjm 1164 2 cultures culture NNS cord-023095-4dannjjm 1164 3 were be VBD cord-023095-4dannjjm 1164 4 incubated incubate VBN cord-023095-4dannjjm 1164 5 for for IN cord-023095-4dannjjm 1164 6 24 24 CD cord-023095-4dannjjm 1164 7 hrs hrs NN cord-023095-4dannjjm 1164 8 with with IN cord-023095-4dannjjm 1164 9 control control NN cord-023095-4dannjjm 1164 10 media medium NNS cord-023095-4dannjjm 1164 11 alone alone RB cord-023095-4dannjjm 1164 12 , , , cord-023095-4dannjjm 1164 13 a a DT cord-023095-4dannjjm 1164 14 clinically clinically RB cord-023095-4dannjjm 1164 15 relevant relevant JJ cord-023095-4dannjjm 1164 16 concentration concentration NN cord-023095-4dannjjm 1164 17 of of IN cord-023095-4dannjjm 1164 18 PBZ PBZ NNP cord-023095-4dannjjm 1164 19 ( ( -LRB- cord-023095-4dannjjm 1164 20 4 4 CD cord-023095-4dannjjm 1164 21 mg mg NNP cord-023095-4dannjjm 1164 22 / / SYM cord-023095-4dannjjm 1164 23 ml ml NNP cord-023095-4dannjjm 1164 24 ) ) -RRB- cord-023095-4dannjjm 1164 25 , , , cord-023095-4dannjjm 1164 26 or or CC cord-023095-4dannjjm 1164 27 the the DT cord-023095-4dannjjm 1164 28 combination combination NN cord-023095-4dannjjm 1164 29 of of IN cord-023095-4dannjjm 1164 30 ASU ASU NNP cord-023095-4dannjjm 1164 31 ( ( -LRB- cord-023095-4dannjjm 1164 32 NMX1000 NMX1000 NNP cord-023095-4dannjjm 1164 33 s s NNP cord-023095-4dannjjm 1164 34 , , , cord-023095-4dannjjm 1164 35 8.3 8.3 CD cord-023095-4dannjjm 1164 36 mg mg NNP cord-023095-4dannjjm 1164 37 / / SYM cord-023095-4dannjjm 1164 38 ml ml NN cord-023095-4dannjjm 1164 39 ) ) -RRB- cord-023095-4dannjjm 1164 40 1 1 CD cord-023095-4dannjjm 1164 41 GLU GLU NNP cord-023095-4dannjjm 1164 42 ( ( -LRB- cord-023095-4dannjjm 1164 43 FCHG49 FCHG49 NNP cord-023095-4dannjjm 1164 44 s s NNP cord-023095-4dannjjm 1164 45 , , , cord-023095-4dannjjm 1164 46 11mg 11mg NN cord-023095-4dannjjm 1164 47 / / SYM cord-023095-4dannjjm 1164 48 ml ml NN cord-023095-4dannjjm 1164 49 ) ) -RRB- cord-023095-4dannjjm 1164 50 1 1 CD cord-023095-4dannjjm 1164 51 CS CS NNP cord-023095-4dannjjm 1164 52 ( ( -LRB- cord-023095-4dannjjm 1164 53 TRH122 TRH122 NNP cord-023095-4dannjjm 1164 54 s s NNP cord-023095-4dannjjm 1164 55 , , , cord-023095-4dannjjm 1164 56 20 20 CD cord-023095-4dannjjm 1164 57 mg mg NNP cord-023095-4dannjjm 1164 58 / / SYM cord-023095-4dannjjm 1164 59 ml ml NNP cord-023095-4dannjjm 1164 60 ) ) -RRB- cord-023095-4dannjjm 1164 61 . . . cord-023095-4dannjjm 1165 1 Articular articular JJ cord-023095-4dannjjm 1165 2 cartilage cartilage NN cord-023095-4dannjjm 1165 3 from from IN cord-023095-4dannjjm 1165 4 joints joint NNS cord-023095-4dannjjm 1165 5 of of IN cord-023095-4dannjjm 1165 6 five five CD cord-023095-4dannjjm 1165 7 HERDA HERDA NNP cord-023095-4dannjjm 1165 8 - - HYPH cord-023095-4dannjjm 1165 9 afflicted afflict VBN cord-023095-4dannjjm 1165 10 horses horse NNS cord-023095-4dannjjm 1165 11 showed show VBD cord-023095-4dannjjm 1165 12 gross gross JJ cord-023095-4dannjjm 1165 13 and and CC cord-023095-4dannjjm 1165 14 histologic histologic JJ cord-023095-4dannjjm 1165 15 evidence evidence NN cord-023095-4dannjjm 1165 16 of of IN cord-023095-4dannjjm 1165 17 osteoarthritic osteoarthritic JJ cord-023095-4dannjjm 1165 18 lesions lesion NNS cord-023095-4dannjjm 1165 19 . . . cord-023095-4dannjjm 1166 1 Chondrocyte Chondrocyte NNP cord-023095-4dannjjm 1166 2 cultures culture NNS cord-023095-4dannjjm 1166 3 from from IN cord-023095-4dannjjm 1166 4 cartilage cartilage NN cord-023095-4dannjjm 1166 5 of of IN cord-023095-4dannjjm 1166 6 horses horse NNS cord-023095-4dannjjm 1166 7 suffering suffer VBG cord-023095-4dannjjm 1166 8 from from IN cord-023095-4dannjjm 1166 9 HERDA HERDA NNP cord-023095-4dannjjm 1166 10 spontaneously spontaneously RB cord-023095-4dannjjm 1166 11 produced produce VBD cord-023095-4dannjjm 1166 12 greater great JJR cord-023095-4dannjjm 1166 13 PGE PGE NNP cord-023095-4dannjjm 1166 14 2 2 CD cord-023095-4dannjjm 1166 15 than than IN cord-023095-4dannjjm 1166 16 chondrocytes chondrocyte NNS cord-023095-4dannjjm 1166 17 from from IN cord-023095-4dannjjm 1166 18 normal normal JJ cord-023095-4dannjjm 1166 19 horses horse NNS cord-023095-4dannjjm 1166 20 ( ( -LRB- cord-023095-4dannjjm 1166 21 41000-fold 41000-fold CD cord-023095-4dannjjm 1166 22 ) ) -RRB- cord-023095-4dannjjm 1166 23 . . . cord-023095-4dannjjm 1167 1 PBZ pbz NN cord-023095-4dannjjm 1167 2 significantly significantly RB cord-023095-4dannjjm 1167 3 decreased decrease VBD cord-023095-4dannjjm 1167 4 PGE PGE NNP cord-023095-4dannjjm 1167 5 2 2 CD cord-023095-4dannjjm 1167 6 production production NN cord-023095-4dannjjm 1167 7 by by IN cord-023095-4dannjjm 1167 8 $ $ $ cord-023095-4dannjjm 1167 9 90 90 CD cord-023095-4dannjjm 1167 10 % % NN cord-023095-4dannjjm 1167 11 ( ( -LRB- cord-023095-4dannjjm 1167 12 p p NN cord-023095-4dannjjm 1167 13 o o CD cord-023095-4dannjjm 1167 14 0.001 0.001 CD cord-023095-4dannjjm 1167 15 ) ) -RRB- cord-023095-4dannjjm 1167 16 . . . cord-023095-4dannjjm 1168 1 The the DT cord-023095-4dannjjm 1168 2 combination combination NN cord-023095-4dannjjm 1168 3 of of IN cord-023095-4dannjjm 1168 4 ASU1-GLU1CS asu1-glu1c NNS cord-023095-4dannjjm 1168 5 also also RB cord-023095-4dannjjm 1168 6 significantly significantly RB cord-023095-4dannjjm 1168 7 reduced reduce VBD cord-023095-4dannjjm 1168 8 PGE PGE NNP cord-023095-4dannjjm 1168 9 2 2 CD cord-023095-4dannjjm 1168 10 production production NN cord-023095-4dannjjm 1168 11 by by IN cord-023095-4dannjjm 1168 12 $ $ $ cord-023095-4dannjjm 1168 13 60 60 CD cord-023095-4dannjjm 1168 14 % % NN cord-023095-4dannjjm 1168 15 ( ( -LRB- cord-023095-4dannjjm 1168 16 p p NN cord-023095-4dannjjm 1168 17 o o CD cord-023095-4dannjjm 1168 18 0.001 0.001 CD cord-023095-4dannjjm 1168 19 ) ) -RRB- cord-023095-4dannjjm 1168 20 . . . cord-023095-4dannjjm 1169 1 The the DT cord-023095-4dannjjm 1169 2 present present JJ cord-023095-4dannjjm 1169 3 study study NN cord-023095-4dannjjm 1169 4 supports support VBZ cord-023095-4dannjjm 1169 5 anecdotal anecdotal JJ cord-023095-4dannjjm 1169 6 findings finding NNS cord-023095-4dannjjm 1169 7 that that WDT cord-023095-4dannjjm 1169 8 horses horse NNS cord-023095-4dannjjm 1169 9 suffering suffer VBG cord-023095-4dannjjm 1169 10 from from IN cord-023095-4dannjjm 1169 11 HERDA HERDA NNP cord-023095-4dannjjm 1169 12 are be VBP cord-023095-4dannjjm 1169 13 likely likely JJ cord-023095-4dannjjm 1169 14 to to TO cord-023095-4dannjjm 1169 15 develop develop VB cord-023095-4dannjjm 1169 16 OA OA NNP cord-023095-4dannjjm 1169 17 . . . cord-023095-4dannjjm 1170 1 The the DT cord-023095-4dannjjm 1170 2 inhibition inhibition NN cord-023095-4dannjjm 1170 3 of of IN cord-023095-4dannjjm 1170 4 PGE PGE NNP cord-023095-4dannjjm 1170 5 2 2 CD cord-023095-4dannjjm 1170 6 synthesis synthesis NN cord-023095-4dannjjm 1170 7 by by IN cord-023095-4dannjjm 1170 8 ASU1GLU1CS asu1glu1cs CD cord-023095-4dannjjm 1170 9 suggests suggest VBZ cord-023095-4dannjjm 1170 10 that that IN cord-023095-4dannjjm 1170 11 this this DT cord-023095-4dannjjm 1170 12 combination combination NN cord-023095-4dannjjm 1170 13 may may MD cord-023095-4dannjjm 1170 14 be be VB cord-023095-4dannjjm 1170 15 beneficial beneficial JJ cord-023095-4dannjjm 1170 16 for for IN cord-023095-4dannjjm 1170 17 the the DT cord-023095-4dannjjm 1170 18 management management NN cord-023095-4dannjjm 1170 19 of of IN cord-023095-4dannjjm 1170 20 OA OA NNP cord-023095-4dannjjm 1170 21 in in IN cord-023095-4dannjjm 1170 22 HERDA HERDA NNP cord-023095-4dannjjm 1170 23 . . . cord-023095-4dannjjm 1171 1 Research research NN cord-023095-4dannjjm 1171 2 supported support VBN cord-023095-4dannjjm 1171 3 by by IN cord-023095-4dannjjm 1171 4 Nutramax Nutramax NNP cord-023095-4dannjjm 1171 5 Laboratories Laboratories NNP cord-023095-4dannjjm 1171 6 , , , cord-023095-4dannjjm 1172 1 Inc. Inc. NNP cord-023095-4dannjjm 1172 2 Equine Equine NNP cord-023095-4dannjjm 1172 3 Inflammatory Inflammatory NNP cord-023095-4dannjjm 1172 4 Airway Airway NNP cord-023095-4dannjjm 1172 5 Disease Disease NNP cord-023095-4dannjjm 1172 6 ( ( -LRB- cord-023095-4dannjjm 1172 7 IAD IAD NNP cord-023095-4dannjjm 1172 8 ) ) -RRB- cord-023095-4dannjjm 1172 9 is be VBZ cord-023095-4dannjjm 1172 10 a a DT cord-023095-4dannjjm 1172 11 common common JJ cord-023095-4dannjjm 1172 12 condition condition NN cord-023095-4dannjjm 1172 13 often often RB cord-023095-4dannjjm 1172 14 treated treat VBN cord-023095-4dannjjm 1172 15 empirically empirically RB cord-023095-4dannjjm 1172 16 with with IN cord-023095-4dannjjm 1172 17 corticosteroids corticosteroid NNS cord-023095-4dannjjm 1172 18 . . . cord-023095-4dannjjm 1173 1 Gene gene NN cord-023095-4dannjjm 1173 2 expression expression NN cord-023095-4dannjjm 1173 3 analysis analysis NN cord-023095-4dannjjm 1173 4 in in IN cord-023095-4dannjjm 1173 5 the the DT cord-023095-4dannjjm 1173 6 bronchoalveolar bronchoalveolar NNP cord-023095-4dannjjm 1173 7 lavage lavage NN cord-023095-4dannjjm 1173 8 fluid fluid NN cord-023095-4dannjjm 1173 9 ( ( -LRB- cord-023095-4dannjjm 1173 10 BALF BALF NNP cord-023095-4dannjjm 1173 11 ) ) -RRB- cord-023095-4dannjjm 1173 12 may may MD cord-023095-4dannjjm 1173 13 help help VB cord-023095-4dannjjm 1173 14 understand understand VB cord-023095-4dannjjm 1173 15 the the DT cord-023095-4dannjjm 1173 16 effects effect NNS cord-023095-4dannjjm 1173 17 of of IN cord-023095-4dannjjm 1173 18 corticosteroids corticosteroid NNS cord-023095-4dannjjm 1173 19 in in IN cord-023095-4dannjjm 1173 20 IAD IAD NNP cord-023095-4dannjjm 1173 21 . . . cord-023095-4dannjjm 1174 1 The the DT cord-023095-4dannjjm 1174 2 first first JJ cord-023095-4dannjjm 1174 3 part part NN cord-023095-4dannjjm 1174 4 of of IN cord-023095-4dannjjm 1174 5 the the DT cord-023095-4dannjjm 1174 6 study study NN cord-023095-4dannjjm 1174 7 aimed aim VBN cord-023095-4dannjjm 1174 8 at at IN cord-023095-4dannjjm 1174 9 identifying identify VBG cord-023095-4dannjjm 1174 10 reference reference NN cord-023095-4dannjjm 1174 11 genes gene NNS cord-023095-4dannjjm 1174 12 in in IN cord-023095-4dannjjm 1174 13 the the DT cord-023095-4dannjjm 1174 14 BALF BALF NNP cord-023095-4dannjjm 1174 15 of of IN cord-023095-4dannjjm 1174 16 IAD IAD NNP cord-023095-4dannjjm 1174 17 horses horse NNS cord-023095-4dannjjm 1174 18 treated treat VBN cord-023095-4dannjjm 1174 19 with with IN cord-023095-4dannjjm 1174 20 corticosteroids corticosteroid NNS cord-023095-4dannjjm 1174 21 . . . cord-023095-4dannjjm 1175 1 The the DT cord-023095-4dannjjm 1175 2 second second JJ cord-023095-4dannjjm 1175 3 part part NN cord-023095-4dannjjm 1175 4 of of IN cord-023095-4dannjjm 1175 5 the the DT cord-023095-4dannjjm 1175 6 study study NN cord-023095-4dannjjm 1175 7 investigated investigate VBD cord-023095-4dannjjm 1175 8 the the DT cord-023095-4dannjjm 1175 9 effects effect NNS cord-023095-4dannjjm 1175 10 of of IN cord-023095-4dannjjm 1175 11 dexamethasone dexamethasone NN cord-023095-4dannjjm 1175 12 and and CC cord-023095-4dannjjm 1175 13 fluticasone fluticasone NN cord-023095-4dannjjm 1175 14 propionate propionate NN cord-023095-4dannjjm 1175 15 treatments treatment NNS cord-023095-4dannjjm 1175 16 on on IN cord-023095-4dannjjm 1175 17 the the DT cord-023095-4dannjjm 1175 18 mRNA mRNA NNP cord-023095-4dannjjm 1175 19 expression expression NN cord-023095-4dannjjm 1175 20 of of IN cord-023095-4dannjjm 1175 21 IL-1b IL-1b NNS cord-023095-4dannjjm 1175 22 , , , cord-023095-4dannjjm 1175 23 IL-4 IL-4 NNP cord-023095-4dannjjm 1175 24 , , , cord-023095-4dannjjm 1175 25 IL-8 IL-8 NNP cord-023095-4dannjjm 1175 26 and and CC cord-023095-4dannjjm 1175 27 IL-17 IL-17 NNP cord-023095-4dannjjm 1175 28 . . . cord-023095-4dannjjm 1176 1 The the DT cord-023095-4dannjjm 1176 2 expression expression NN cord-023095-4dannjjm 1176 3 stability stability NN cord-023095-4dannjjm 1176 4 of of IN cord-023095-4dannjjm 1176 5 seven seven CD cord-023095-4dannjjm 1176 6 candidate candidate NN cord-023095-4dannjjm 1176 7 reference reference NN cord-023095-4dannjjm 1176 8 genes gene NNS cord-023095-4dannjjm 1176 9 was be VBD cord-023095-4dannjjm 1176 10 determined determine VBN cord-023095-4dannjjm 1176 11 in in IN cord-023095-4dannjjm 1176 12 BALF BALF NNP cord-023095-4dannjjm 1176 13 taken take VBN cord-023095-4dannjjm 1176 14 pre pre AFX cord-023095-4dannjjm 1176 15 - - HYPH cord-023095-4dannjjm 1176 16 and and CC cord-023095-4dannjjm 1176 17 post post JJ cord-023095-4dannjjm 1176 18 - - NN cord-023095-4dannjjm 1176 19 treatment treatment NN cord-023095-4dannjjm 1176 20 with with IN cord-023095-4dannjjm 1176 21 dexamethasone dexamethasone NN cord-023095-4dannjjm 1176 22 and and CC cord-023095-4dannjjm 1176 23 fluticasone fluticasone NN cord-023095-4dannjjm 1176 24 propionate propionate NN cord-023095-4dannjjm 1176 25 in in IN cord-023095-4dannjjm 1176 26 horses horse NNS cord-023095-4dannjjm 1176 27 with with IN cord-023095-4dannjjm 1176 28 IAD IAD NNP cord-023095-4dannjjm 1176 29 . . . cord-023095-4dannjjm 1177 1 Primers primer NNS cord-023095-4dannjjm 1177 2 ' ' POS cord-023095-4dannjjm 1177 3 efficiencies efficiency NNS cord-023095-4dannjjm 1177 4 were be VBD cord-023095-4dannjjm 1177 5 calculated calculate VBN cord-023095-4dannjjm 1177 6 using use VBG cord-023095-4dannjjm 1177 7 LinRegPCR LinRegPCR NNP cord-023095-4dannjjm 1177 8 . . . cord-023095-4dannjjm 1178 1 NormFinder NormFinder NNP cord-023095-4dannjjm 1178 2 , , , cord-023095-4dannjjm 1178 3 GeNorm genorm NN cord-023095-4dannjjm 1178 4 and and CC cord-023095-4dannjjm 1179 1 qBasePlus qBasePlus NNP cord-023095-4dannjjm 1179 2 softwares software NNS cord-023095-4dannjjm 1179 3 were be VBD cord-023095-4dannjjm 1179 4 used use VBN cord-023095-4dannjjm 1179 5 to to TO cord-023095-4dannjjm 1179 6 rank rank VB cord-023095-4dannjjm 1179 7 the the DT cord-023095-4dannjjm 1179 8 genes gene NNS cord-023095-4dannjjm 1179 9 according accord VBG cord-023095-4dannjjm 1179 10 to to IN cord-023095-4dannjjm 1179 11 their -PRON- PRP$ cord-023095-4dannjjm 1179 12 stability stability NN cord-023095-4dannjjm 1179 13 . . . cord-023095-4dannjjm 1180 1 GAPDH GAPDH NNP cord-023095-4dannjjm 1180 2 was be VBD cord-023095-4dannjjm 1180 3 the the DT cord-023095-4dannjjm 1180 4 most most RBS cord-023095-4dannjjm 1180 5 stably stably RB cord-023095-4dannjjm 1180 6 expressed express VBN cord-023095-4dannjjm 1180 7 gene gene NN cord-023095-4dannjjm 1180 8 whereas whereas IN cord-023095-4dannjjm 1180 9 B2 B2 NNP cord-023095-4dannjjm 1180 10 M M NNP cord-023095-4dannjjm 1180 11 was be VBD cord-023095-4dannjjm 1180 12 the the DT cord-023095-4dannjjm 1180 13 least least JJS cord-023095-4dannjjm 1180 14 stable stable JJ cord-023095-4dannjjm 1180 15 gene gene NN cord-023095-4dannjjm 1180 16 . . . cord-023095-4dannjjm 1181 1 In in IN cord-023095-4dannjjm 1181 2 addition addition NN cord-023095-4dannjjm 1181 3 , , , cord-023095-4dannjjm 1181 4 GeNorm genorm NN cord-023095-4dannjjm 1181 5 analysis analysis NN cord-023095-4dannjjm 1181 6 revealed reveal VBD cord-023095-4dannjjm 1181 7 that that IN cord-023095-4dannjjm 1181 8 the the DT cord-023095-4dannjjm 1181 9 number number NN cord-023095-4dannjjm 1181 10 of of IN cord-023095-4dannjjm 1181 11 genes gene NNS cord-023095-4dannjjm 1181 12 required require VBN cord-023095-4dannjjm 1181 13 for for IN cord-023095-4dannjjm 1181 14 optimal optimal JJ cord-023095-4dannjjm 1181 15 normalization normalization NN cord-023095-4dannjjm 1181 16 was be VBD cord-023095-4dannjjm 1181 17 four four CD cord-023095-4dannjjm 1181 18 ( ( -LRB- cord-023095-4dannjjm 1181 19 GAPDH GAPDH NNP cord-023095-4dannjjm 1181 20 , , , cord-023095-4dannjjm 1181 21 SDHA SDHA NNP cord-023095-4dannjjm 1181 22 , , , cord-023095-4dannjjm 1181 23 HPRT HPRT NNP cord-023095-4dannjjm 1181 24 , , , cord-023095-4dannjjm 1181 25 RPL32 RPL32 NNP cord-023095-4dannjjm 1181 26 ) ) -RRB- cord-023095-4dannjjm 1181 27 . . . cord-023095-4dannjjm 1182 1 In in IN cord-023095-4dannjjm 1182 2 the the DT cord-023095-4dannjjm 1182 3 second second JJ cord-023095-4dannjjm 1182 4 part part NN cord-023095-4dannjjm 1182 5 of of IN cord-023095-4dannjjm 1182 6 the the DT cord-023095-4dannjjm 1182 7 study study NN cord-023095-4dannjjm 1182 8 the the DT cord-023095-4dannjjm 1182 9 mRNA mRNA NNP cord-023095-4dannjjm 1182 10 expression expression NN cord-023095-4dannjjm 1182 11 of of IN cord-023095-4dannjjm 1182 12 IL-1b IL-1b NNS cord-023095-4dannjjm 1182 13 , , , cord-023095-4dannjjm 1182 14 IL-4 IL-4 NNP cord-023095-4dannjjm 1182 15 , , , cord-023095-4dannjjm 1182 16 IL-8 IL-8 NNP cord-023095-4dannjjm 1182 17 and and CC cord-023095-4dannjjm 1182 18 IL-17 IL-17 NNP cord-023095-4dannjjm 1182 19 was be VBD cord-023095-4dannjjm 1182 20 measured measure VBN cord-023095-4dannjjm 1182 21 in in IN cord-023095-4dannjjm 1182 22 BALF BALF NNP cord-023095-4dannjjm 1182 23 samples sample NNS cord-023095-4dannjjm 1182 24 from from IN cord-023095-4dannjjm 1182 25 seven seven CD cord-023095-4dannjjm 1182 26 IAD IAD NNP cord-023095-4dannjjm 1182 27 horses horse NNS cord-023095-4dannjjm 1182 28 treated treat VBN cord-023095-4dannjjm 1182 29 in in IN cord-023095-4dannjjm 1182 30 a a DT cord-023095-4dannjjm 1182 31 randomized randomized JJ cord-023095-4dannjjm 1182 32 cross cross NN cord-023095-4dannjjm 1182 33 - - HYPH cord-023095-4dannjjm 1182 34 over over RP cord-023095-4dannjjm 1182 35 design design NN cord-023095-4dannjjm 1182 36 with with IN cord-023095-4dannjjm 1182 37 dexamethasone dexamethasone NNP cord-023095-4dannjjm 1182 38 ( ( -LRB- cord-023095-4dannjjm 1182 39 0.05 0.05 CD cord-023095-4dannjjm 1182 40 mg mg NNP cord-023095-4dannjjm 1182 41 / / SYM cord-023095-4dannjjm 1182 42 kg kg NNP cord-023095-4dannjjm 1182 43 SID SID NNP cord-023095-4dannjjm 1182 44 , , , cord-023095-4dannjjm 1182 45 15 15 CD cord-023095-4dannjjm 1182 46 days day NNS cord-023095-4dannjjm 1182 47 ) ) -RRB- cord-023095-4dannjjm 1182 48 or or CC cord-023095-4dannjjm 1182 49 inhaled inhale VBN cord-023095-4dannjjm 1182 50 fluticasone fluticasone NN cord-023095-4dannjjm 1182 51 propionate propionate NN cord-023095-4dannjjm 1182 52 ( ( -LRB- cord-023095-4dannjjm 1182 53 3000 3000 CD cord-023095-4dannjjm 1182 54 mcg mcg NN cord-023095-4dannjjm 1182 55 BID BID NNP cord-023095-4dannjjm 1182 56 with with IN cord-023095-4dannjjm 1182 57 Aerohippus Aerohippus NNP cord-023095-4dannjjm 1182 58 , , , cord-023095-4dannjjm 1182 59 15 15 CD cord-023095-4dannjjm 1182 60 days day NNS cord-023095-4dannjjm 1182 61 ) ) -RRB- cord-023095-4dannjjm 1182 62 . . . cord-023095-4dannjjm 1183 1 The the DT cord-023095-4dannjjm 1183 2 BALF BALF NNP cord-023095-4dannjjm 1183 3 samples sample NNS cord-023095-4dannjjm 1183 4 were be VBD cord-023095-4dannjjm 1183 5 taken take VBN cord-023095-4dannjjm 1183 6 at at IN cord-023095-4dannjjm 1183 7 baseline baseline NN cord-023095-4dannjjm 1183 8 and and CC cord-023095-4dannjjm 1183 9 after after IN cord-023095-4dannjjm 1183 10 each each DT cord-023095-4dannjjm 1183 11 treatment treatment NN cord-023095-4dannjjm 1183 12 period period NN cord-023095-4dannjjm 1183 13 . . . cord-023095-4dannjjm 1184 1 There there EX cord-023095-4dannjjm 1184 2 was be VBD cord-023095-4dannjjm 1184 3 no no DT cord-023095-4dannjjm 1184 4 significant significant JJ cord-023095-4dannjjm 1184 5 effect effect NN cord-023095-4dannjjm 1184 6 of of IN cord-023095-4dannjjm 1184 7 the the DT cord-023095-4dannjjm 1184 8 corticosteroids corticosteroid NNS cord-023095-4dannjjm 1184 9 treatment treatment NN cord-023095-4dannjjm 1184 10 on on IN cord-023095-4dannjjm 1184 11 the the DT cord-023095-4dannjjm 1184 12 mRNA mRNA NNP cord-023095-4dannjjm 1184 13 expression expression NN cord-023095-4dannjjm 1184 14 of of IN cord-023095-4dannjjm 1184 15 IL-1b IL-1b NNS cord-023095-4dannjjm 1184 16 , , , cord-023095-4dannjjm 1184 17 IL-4 IL-4 NNP cord-023095-4dannjjm 1184 18 and and CC cord-023095-4dannjjm 1184 19 IL-8 IL-8 NNP cord-023095-4dannjjm 1184 20 in in IN cord-023095-4dannjjm 1184 21 the the DT cord-023095-4dannjjm 1184 22 BALF BALF NNP cord-023095-4dannjjm 1184 23 . . . cord-023095-4dannjjm 1185 1 The the DT cord-023095-4dannjjm 1185 2 mRNA mrna NN cord-023095-4dannjjm 1185 3 expression expression NN cord-023095-4dannjjm 1185 4 of of IN cord-023095-4dannjjm 1185 5 IL-17 IL-17 NNP cord-023095-4dannjjm 1185 6 was be VBD cord-023095-4dannjjm 1185 7 suppressed suppress VBN cord-023095-4dannjjm 1185 8 by by IN cord-023095-4dannjjm 1185 9 dexamethasone dexamethasone NN cord-023095-4dannjjm 1185 10 and and CC cord-023095-4dannjjm 1185 11 fluticasone fluticasone NN cord-023095-4dannjjm 1185 12 propionate propionate NN cord-023095-4dannjjm 1185 13 treatments treatment NNS cord-023095-4dannjjm 1185 14 . . . cord-023095-4dannjjm 1186 1 Pneumonia pneumonia NN cord-023095-4dannjjm 1186 2 is be VBZ cord-023095-4dannjjm 1186 3 observed observe VBN cord-023095-4dannjjm 1186 4 in in IN cord-023095-4dannjjm 1186 5 horses horse NNS cord-023095-4dannjjm 1186 6 after after IN cord-023095-4dannjjm 1186 7 long long JJ cord-023095-4dannjjm 1186 8 distance distance NN cord-023095-4dannjjm 1186 9 transportation transportation NN cord-023095-4dannjjm 1186 10 in in IN cord-023095-4dannjjm 1186 11 association association NN cord-023095-4dannjjm 1186 12 with with IN cord-023095-4dannjjm 1186 13 confinement confinement NN cord-023095-4dannjjm 1186 14 of of IN cord-023095-4dannjjm 1186 15 horses horse NNS cord-023095-4dannjjm 1186 16 ' ' POS cord-023095-4dannjjm 1186 17 head head NN cord-023095-4dannjjm 1186 18 position position NN cord-023095-4dannjjm 1186 19 leading lead VBG cord-023095-4dannjjm 1186 20 to to IN cord-023095-4dannjjm 1186 21 a a DT cord-023095-4dannjjm 1186 22 reduction reduction NN cord-023095-4dannjjm 1186 23 in in IN cord-023095-4dannjjm 1186 24 tracheal tracheal JJ cord-023095-4dannjjm 1186 25 mucociliary mucociliary JJ cord-023095-4dannjjm 1186 26 clearance clearance NN cord-023095-4dannjjm 1186 27 time time NN cord-023095-4dannjjm 1186 28 ( ( -LRB- cord-023095-4dannjjm 1186 29 TMCT TMCT NNP cord-023095-4dannjjm 1186 30 ) ) -RRB- cord-023095-4dannjjm 1186 31 . . . cord-023095-4dannjjm 1187 1 We -PRON- PRP cord-023095-4dannjjm 1187 2 hypothesize hypothesize VBP cord-023095-4dannjjm 1187 3 that that IN cord-023095-4dannjjm 1187 4 clenbuterol clenbuterol NN cord-023095-4dannjjm 1187 5 , , , cord-023095-4dannjjm 1187 6 a a DT cord-023095-4dannjjm 1187 7 beta-2 beta-2 NN cord-023095-4dannjjm 1187 8 agonist agonist NN cord-023095-4dannjjm 1187 9 shown show VBN cord-023095-4dannjjm 1187 10 to to TO cord-023095-4dannjjm 1187 11 increase increase VB cord-023095-4dannjjm 1187 12 TMCT TMCT NNS cord-023095-4dannjjm 1187 13 in in IN cord-023095-4dannjjm 1187 14 the the DT cord-023095-4dannjjm 1187 15 horse horse NN cord-023095-4dannjjm 1187 16 , , , cord-023095-4dannjjm 1187 17 will will MD cord-023095-4dannjjm 1187 18 ameliorate ameliorate VB cord-023095-4dannjjm 1187 19 the the DT cord-023095-4dannjjm 1187 20 affect affect NN cord-023095-4dannjjm 1187 21 of of IN cord-023095-4dannjjm 1187 22 a a DT cord-023095-4dannjjm 1187 23 fixed fixed JJ cord-023095-4dannjjm 1187 24 head head NN cord-023095-4dannjjm 1187 25 position position NN cord-023095-4dannjjm 1187 26 on on IN cord-023095-4dannjjm 1187 27 large large JJ cord-023095-4dannjjm 1187 28 airway airway NN cord-023095-4dannjjm 1187 29 contamination contamination NN cord-023095-4dannjjm 1187 30 and and CC cord-023095-4dannjjm 1187 31 inflammation inflammation NN cord-023095-4dannjjm 1187 32 in in IN cord-023095-4dannjjm 1187 33 a a DT cord-023095-4dannjjm 1187 34 long long JJ cord-023095-4dannjjm 1187 35 - - HYPH cord-023095-4dannjjm 1187 36 distance distance NN cord-023095-4dannjjm 1187 37 shipping shipping NN cord-023095-4dannjjm 1187 38 model model NN cord-023095-4dannjjm 1187 39 . . . cord-023095-4dannjjm 1188 1 Six six CD cord-023095-4dannjjm 1188 2 adult adult NN cord-023095-4dannjjm 1188 3 horses horse NNS cord-023095-4dannjjm 1188 4 were be VBD cord-023095-4dannjjm 1188 5 enrolled enrol VBN cord-023095-4dannjjm 1188 6 in in IN cord-023095-4dannjjm 1188 7 a a DT cord-023095-4dannjjm 1188 8 cross cross NN cord-023095-4dannjjm 1188 9 - - HYPH cord-023095-4dannjjm 1188 10 over over RP cord-023095-4dannjjm 1188 11 design design NN cord-023095-4dannjjm 1188 12 prospective prospective JJ cord-023095-4dannjjm 1188 13 study study NN cord-023095-4dannjjm 1188 14 . . . cord-023095-4dannjjm 1189 1 Horses horse NNS cord-023095-4dannjjm 1189 2 were be VBD cord-023095-4dannjjm 1189 3 housed house VBN cord-023095-4dannjjm 1189 4 with with IN cord-023095-4dannjjm 1189 5 their -PRON- PRP$ cord-023095-4dannjjm 1189 6 heads head NNS cord-023095-4dannjjm 1189 7 in in IN cord-023095-4dannjjm 1189 8 a a DT cord-023095-4dannjjm 1189 9 fixed fix VBN cord-023095-4dannjjm 1189 10 position position NN cord-023095-4dannjjm 1189 11 for for IN cord-023095-4dannjjm 1189 12 48 48 CD cord-023095-4dannjjm 1189 13 hours hour NNS cord-023095-4dannjjm 1189 14 to to TO cord-023095-4dannjjm 1189 15 simulate simulate VB cord-023095-4dannjjm 1189 16 long long JJ cord-023095-4dannjjm 1189 17 distance distance NN cord-023095-4dannjjm 1189 18 transport transport NN cord-023095-4dannjjm 1189 19 , , , cord-023095-4dannjjm 1189 20 and and CC cord-023095-4dannjjm 1189 21 treated treat VBN cord-023095-4dannjjm 1189 22 with with IN cord-023095-4dannjjm 1189 23 clenbuterol clenbuterol NN cord-023095-4dannjjm 1189 24 ( ( -LRB- cord-023095-4dannjjm 1189 25 0.8 0.8 CD cord-023095-4dannjjm 1189 26 ug ug NNP cord-023095-4dannjjm 1189 27 / / SYM cord-023095-4dannjjm 1189 28 kg kg NNP cord-023095-4dannjjm 1189 29 PO po NN cord-023095-4dannjjm 1189 30 q12 q12 NN cord-023095-4dannjjm 1189 31 h h NNP cord-023095-4dannjjm 1189 32 ) ) -RRB- cord-023095-4dannjjm 1189 33 or or CC cord-023095-4dannjjm 1189 34 a a DT cord-023095-4dannjjm 1189 35 placebo placebo NN cord-023095-4dannjjm 1189 36 starting start VBG cord-023095-4dannjjm 1189 37 12 12 CD cord-023095-4dannjjm 1189 38 hours hour NNS cord-023095-4dannjjm 1189 39 before before IN cord-023095-4dannjjm 1189 40 simulated simulated JJ cord-023095-4dannjjm 1189 41 shipping shipping NN cord-023095-4dannjjm 1189 42 . . . cord-023095-4dannjjm 1190 1 TMCT TMCT NNP cord-023095-4dannjjm 1190 2 was be VBD cord-023095-4dannjjm 1190 3 measured measure VBN cord-023095-4dannjjm 1190 4 using use VBG cord-023095-4dannjjm 1190 5 a a DT cord-023095-4dannjjm 1190 6 charcoal charcoal NN cord-023095-4dannjjm 1190 7 clearance clearance NN cord-023095-4dannjjm 1190 8 technique technique NN cord-023095-4dannjjm 1190 9 . . . cord-023095-4dannjjm 1191 1 Data datum NNS cord-023095-4dannjjm 1191 2 were be VBD cord-023095-4dannjjm 1191 3 collected collect VBN cord-023095-4dannjjm 1191 4 at at IN cord-023095-4dannjjm 1191 5 baseline baseline NN cord-023095-4dannjjm 1191 6 and and CC cord-023095-4dannjjm 1191 7 48 48 CD cord-023095-4dannjjm 1191 8 hours hour NNS cord-023095-4dannjjm 1191 9 , , , cord-023095-4dannjjm 1191 10 and and CC cord-023095-4dannjjm 1191 11 included include VBD cord-023095-4dannjjm 1191 12 TMCT TMCT NNP cord-023095-4dannjjm 1191 13 , , , cord-023095-4dannjjm 1191 14 tracheal tracheal JJ cord-023095-4dannjjm 1191 15 wash wash NN cord-023095-4dannjjm 1191 16 cytology cytology NN cord-023095-4dannjjm 1191 17 and and CC cord-023095-4dannjjm 1191 18 quantitative quantitative JJ cord-023095-4dannjjm 1191 19 culture culture NN cord-023095-4dannjjm 1191 20 , , , cord-023095-4dannjjm 1191 21 rectal rectal JJ cord-023095-4dannjjm 1191 22 temperature temperature NN cord-023095-4dannjjm 1191 23 , , , cord-023095-4dannjjm 1191 24 CBC CBC NNP cord-023095-4dannjjm 1191 25 , , , cord-023095-4dannjjm 1191 26 fibrinogen fibrinogen NN cord-023095-4dannjjm 1191 27 , , , cord-023095-4dannjjm 1191 28 and and CC cord-023095-4dannjjm 1191 29 serum serum NN cord-023095-4dannjjm 1191 30 TNFa TNFa NNS cord-023095-4dannjjm 1191 31 , , , cord-023095-4dannjjm 1191 32 IL-10 IL-10 NNP cord-023095-4dannjjm 1191 33 and and CC cord-023095-4dannjjm 1191 34 IL-2 IL-2 NNP cord-023095-4dannjjm 1191 35 levels level NNS cord-023095-4dannjjm 1191 36 . . . cord-023095-4dannjjm 1192 1 There there EX cord-023095-4dannjjm 1192 2 was be VBD cord-023095-4dannjjm 1192 3 a a DT cord-023095-4dannjjm 1192 4 3-week 3-week CD cord-023095-4dannjjm 1192 5 washout washout NN cord-023095-4dannjjm 1192 6 between between IN cord-023095-4dannjjm 1192 7 study study NN cord-023095-4dannjjm 1192 8 arms arm NNS cord-023095-4dannjjm 1192 9 , , , cord-023095-4dannjjm 1192 10 and and CC cord-023095-4dannjjm 1192 11 each each DT cord-023095-4dannjjm 1192 12 horse horse NN cord-023095-4dannjjm 1192 13 served serve VBD cord-023095-4dannjjm 1192 14 as as IN cord-023095-4dannjjm 1192 15 its -PRON- PRP$ cord-023095-4dannjjm 1192 16 own own JJ cord-023095-4dannjjm 1192 17 control control NN cord-023095-4dannjjm 1192 18 . . . cord-023095-4dannjjm 1193 1 The the DT cord-023095-4dannjjm 1193 2 data datum NNS cord-023095-4dannjjm 1193 3 was be VBD cord-023095-4dannjjm 1193 4 analyzed analyze VBN cord-023095-4dannjjm 1193 5 using use VBG cord-023095-4dannjjm 1193 6 regression regression NN cord-023095-4dannjjm 1193 7 analysis analysis NN cord-023095-4dannjjm 1193 8 and and CC cord-023095-4dannjjm 1193 9 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 1193 10 rank rank NN cord-023095-4dannjjm 1193 11 - - HYPH cord-023095-4dannjjm 1193 12 sum sum NN cord-023095-4dannjjm 1193 13 tests test NNS cord-023095-4dannjjm 1193 14 . . . cord-023095-4dannjjm 1194 1 No no DT cord-023095-4dannjjm 1194 2 statistically statistically RB cord-023095-4dannjjm 1194 3 significant significant JJ cord-023095-4dannjjm 1194 4 difference difference NN cord-023095-4dannjjm 1194 5 was be VBD cord-023095-4dannjjm 1194 6 seen see VBN cord-023095-4dannjjm 1194 7 between between IN cord-023095-4dannjjm 1194 8 treatment treatment NN cord-023095-4dannjjm 1194 9 and and CC cord-023095-4dannjjm 1194 10 placebo placebo NN cord-023095-4dannjjm 1194 11 groups group NNS cord-023095-4dannjjm 1194 12 for for IN cord-023095-4dannjjm 1194 13 any any DT cord-023095-4dannjjm 1194 14 of of IN cord-023095-4dannjjm 1194 15 the the DT cord-023095-4dannjjm 1194 16 variables variable NNS cord-023095-4dannjjm 1194 17 investigated investigate VBN cord-023095-4dannjjm 1194 18 . . . cord-023095-4dannjjm 1195 1 TMCT TMCT NNP cord-023095-4dannjjm 1195 2 did do VBD cord-023095-4dannjjm 1195 3 not not RB cord-023095-4dannjjm 1195 4 differ differ VB cord-023095-4dannjjm 1195 5 after after IN cord-023095-4dannjjm 1195 6 treatment treatment NN cord-023095-4dannjjm 1195 7 ( ( -LRB- cord-023095-4dannjjm 1195 8 1.71 1.71 CD cord-023095-4dannjjm 1195 9 AE AE NNP cord-023095-4dannjjm 1195 10 0.64 0.64 CD cord-023095-4dannjjm 1195 11 cm cm NNP cord-023095-4dannjjm 1195 12 / / SYM cord-023095-4dannjjm 1195 13 min min NNP cord-023095-4dannjjm 1195 14 ) ) -RRB- cord-023095-4dannjjm 1195 15 versus versus IN cord-023095-4dannjjm 1195 16 placebo placebo NN cord-023095-4dannjjm 1195 17 ( ( -LRB- cord-023095-4dannjjm 1195 18 1.55 1.55 CD cord-023095-4dannjjm 1195 19 AE AE NNP cord-023095-4dannjjm 1195 20 0.82 0.82 CD cord-023095-4dannjjm 1195 21 cm/ cm/ NN cord-023095-4dannjjm 1195 22 min min NN cord-023095-4dannjjm 1195 23 ; ; : cord-023095-4dannjjm 1195 24 P p NN cord-023095-4dannjjm 1195 25 4 4 CD cord-023095-4dannjjm 1195 26 0.10 0.10 CD cord-023095-4dannjjm 1195 27 ) ) -RRB- cord-023095-4dannjjm 1195 28 , , , cord-023095-4dannjjm 1195 29 and and CC cord-023095-4dannjjm 1195 30 intratracheal intratracheal JJ cord-023095-4dannjjm 1195 31 bacterial bacterial JJ cord-023095-4dannjjm 1195 32 counts count NNS cord-023095-4dannjjm 1195 33 were be VBD cord-023095-4dannjjm 1195 34 similar similar JJ cord-023095-4dannjjm 1195 35 for for IN cord-023095-4dannjjm 1195 36 treatment treatment NN cord-023095-4dannjjm 1195 37 ( ( -LRB- cord-023095-4dannjjm 1195 38 105 105 CD cord-023095-4dannjjm 1195 39 Â â CD cord-023095-4dannjjm 1195 40 10 10 CD cord-023095-4dannjjm 1195 41 3 3 CD cord-023095-4dannjjm 1195 42 AE AE NNP cord-023095-4dannjjm 1195 43 42 42 CD cord-023095-4dannjjm 1195 44 Â â NN cord-023095-4dannjjm 1195 45 103 103 CD cord-023095-4dannjjm 1195 46 cfu cfu NN cord-023095-4dannjjm 1195 47 ; ; : cord-023095-4dannjjm 1195 48 P p NN cord-023095-4dannjjm 1195 49 4 4 CD cord-023095-4dannjjm 1195 50 0.10 0.10 CD cord-023095-4dannjjm 1195 51 ) ) -RRB- cord-023095-4dannjjm 1195 52 and and CC cord-023095-4dannjjm 1195 53 placebo placebo NN cord-023095-4dannjjm 1195 54 ( ( -LRB- cord-023095-4dannjjm 1195 55 98 98 CD cord-023095-4dannjjm 1195 56 Â â CD cord-023095-4dannjjm 1195 57 10 10 CD cord-023095-4dannjjm 1195 58 3 3 CD cord-023095-4dannjjm 1195 59 AE AE NNP cord-023095-4dannjjm 1195 60 41 41 CD cord-023095-4dannjjm 1195 61 Â â CD cord-023095-4dannjjm 1195 62 103 103 CD cord-023095-4dannjjm 1195 63 cfu cfu NNP cord-023095-4dannjjm 1195 64 ) ) -RRB- cord-023095-4dannjjm 1195 65 groups group NNS cord-023095-4dannjjm 1195 66 . . . cord-023095-4dannjjm 1196 1 A a DT cord-023095-4dannjjm 1196 2 reduction reduction NN cord-023095-4dannjjm 1196 3 of of IN cord-023095-4dannjjm 1196 4 tracheal tracheal NN cord-023095-4dannjjm 1196 5 b b NN cord-023095-4dannjjm 1196 6 hemolytic hemolytic JJ cord-023095-4dannjjm 1196 7 Streptococcus streptococcus NN cord-023095-4dannjjm 1196 8 . . . cord-023095-4dannjjm 1196 9 spp spp NNS cord-023095-4dannjjm 1196 10 . . . cord-023095-4dannjjm 1197 1 after after IN cord-023095-4dannjjm 1197 2 clenbuterol clenbuterol NNP cord-023095-4dannjjm 1197 3 versus versus IN cord-023095-4dannjjm 1197 4 placebo placebo NN cord-023095-4dannjjm 1197 5 was be VBD cord-023095-4dannjjm 1197 6 also also RB cord-023095-4dannjjm 1197 7 nonsignificant nonsignificant JJ cord-023095-4dannjjm 1197 8 ( ( -LRB- cord-023095-4dannjjm 1197 9 0 0 CD cord-023095-4dannjjm 1197 10 % % NN cord-023095-4dannjjm 1197 11 versus versus IN cord-023095-4dannjjm 1197 12 33 33 CD cord-023095-4dannjjm 1197 13 % % NN cord-023095-4dannjjm 1197 14 ; ; : cord-023095-4dannjjm 1197 15 P p NN cord-023095-4dannjjm 1197 16 4 4 CD cord-023095-4dannjjm 1197 17 0.10 0.10 CD cord-023095-4dannjjm 1197 18 ) ) -RRB- cord-023095-4dannjjm 1197 19 . . . cord-023095-4dannjjm 1198 1 In in IN cord-023095-4dannjjm 1198 2 conclusion conclusion NN cord-023095-4dannjjm 1198 3 , , , cord-023095-4dannjjm 1198 4 treatment treatment NN cord-023095-4dannjjm 1198 5 with with IN cord-023095-4dannjjm 1198 6 clenbuterol clenbuterol NN cord-023095-4dannjjm 1198 7 does do VBZ cord-023095-4dannjjm 1198 8 not not RB cord-023095-4dannjjm 1198 9 appear appear VB cord-023095-4dannjjm 1198 10 to to TO cord-023095-4dannjjm 1198 11 combat combat VB cord-023095-4dannjjm 1198 12 the the DT cord-023095-4dannjjm 1198 13 deleterious deleterious JJ cord-023095-4dannjjm 1198 14 effects effect NNS cord-023095-4dannjjm 1198 15 of of IN cord-023095-4dannjjm 1198 16 this this DT cord-023095-4dannjjm 1198 17 long long JJ cord-023095-4dannjjm 1198 18 - - HYPH cord-023095-4dannjjm 1198 19 term term NN cord-023095-4dannjjm 1198 20 shipping shipping NN cord-023095-4dannjjm 1198 21 model model NN cord-023095-4dannjjm 1198 22 . . . cord-023095-4dannjjm 1199 1 Breathing breathe VBG cord-023095-4dannjjm 1199 2 cold cold JJ cord-023095-4dannjjm 1199 3 air air NN cord-023095-4dannjjm 1199 4 during during IN cord-023095-4dannjjm 1199 5 strenuous strenuous JJ cord-023095-4dannjjm 1199 6 exercise exercise NN cord-023095-4dannjjm 1199 7 is be VBZ cord-023095-4dannjjm 1199 8 associated associate VBN cord-023095-4dannjjm 1199 9 with with IN cord-023095-4dannjjm 1199 10 airway airway JJ cord-023095-4dannjjm 1199 11 inflammation inflammation NN cord-023095-4dannjjm 1199 12 . . . cord-023095-4dannjjm 1200 1 Under under IN cord-023095-4dannjjm 1200 2 these these DT cord-023095-4dannjjm 1200 3 conditions condition NNS cord-023095-4dannjjm 1200 4 , , , cord-023095-4dannjjm 1200 5 warming warming NN cord-023095-4dannjjm 1200 6 and and CC cord-023095-4dannjjm 1200 7 humidification humidification NN cord-023095-4dannjjm 1200 8 of of IN cord-023095-4dannjjm 1200 9 inspired inspire VBN cord-023095-4dannjjm 1200 10 air air NN cord-023095-4dannjjm 1200 11 occurs occur VBZ cord-023095-4dannjjm 1200 12 in in IN cord-023095-4dannjjm 1200 13 the the DT cord-023095-4dannjjm 1200 14 lower low JJR cord-023095-4dannjjm 1200 15 respiratory respiratory JJ cord-023095-4dannjjm 1200 16 tract tract NN cord-023095-4dannjjm 1200 17 resulting result VBG cord-023095-4dannjjm 1200 18 in in IN cord-023095-4dannjjm 1200 19 mucosal mucosal JJ cord-023095-4dannjjm 1200 20 cooling cooling NN cord-023095-4dannjjm 1200 21 , , , cord-023095-4dannjjm 1200 22 desiccation desiccation NN cord-023095-4dannjjm 1200 23 , , , cord-023095-4dannjjm 1200 24 and and CC cord-023095-4dannjjm 1200 25 hyperosmolarity hyperosmolarity NN cord-023095-4dannjjm 1200 26 . . . cord-023095-4dannjjm 1201 1 The the DT cord-023095-4dannjjm 1201 2 purpose purpose NN cord-023095-4dannjjm 1201 3 of of IN cord-023095-4dannjjm 1201 4 this this DT cord-023095-4dannjjm 1201 5 research research NN cord-023095-4dannjjm 1201 6 was be VBD cord-023095-4dannjjm 1201 7 to to TO cord-023095-4dannjjm 1201 8 test test VB cord-023095-4dannjjm 1201 9 the the DT cord-023095-4dannjjm 1201 10 hypothesis hypothesis NN cord-023095-4dannjjm 1201 11 that that IN cord-023095-4dannjjm 1201 12 airway airway NNP cord-023095-4dannjjm 1201 13 hypertonicity hypertonicity NN cord-023095-4dannjjm 1201 14 causes cause VBZ cord-023095-4dannjjm 1201 15 inflammatory inflammatory JJ cord-023095-4dannjjm 1201 16 cell cell NN cord-023095-4dannjjm 1201 17 migration migration NN cord-023095-4dannjjm 1201 18 and and CC cord-023095-4dannjjm 1201 19 alterations alteration NNS cord-023095-4dannjjm 1201 20 in in IN cord-023095-4dannjjm 1201 21 cytokine cytokine JJ cord-023095-4dannjjm 1201 22 expression expression NN cord-023095-4dannjjm 1201 23 associated associate VBN cord-023095-4dannjjm 1201 24 with with IN cord-023095-4dannjjm 1201 25 exercise exercise NN cord-023095-4dannjjm 1201 26 induced induce VBN cord-023095-4dannjjm 1201 27 airway airway NN cord-023095-4dannjjm 1201 28 inflammation inflammation NN cord-023095-4dannjjm 1201 29 . . . cord-023095-4dannjjm 1202 1 Horses horse NNS cord-023095-4dannjjm 1202 2 ( ( -LRB- cord-023095-4dannjjm 1202 3 n n NN cord-023095-4dannjjm 1202 4 5 5 CD cord-023095-4dannjjm 1202 5 9 9 CD cord-023095-4dannjjm 1202 6 ) ) -RRB- cord-023095-4dannjjm 1202 7 were be VBD cord-023095-4dannjjm 1202 8 examined examine VBN cord-023095-4dannjjm 1202 9 in in IN cord-023095-4dannjjm 1202 10 a a DT cord-023095-4dannjjm 1202 11 randomized randomized JJ cord-023095-4dannjjm 1202 12 crossover crossover NN cord-023095-4dannjjm 1202 13 design design NN cord-023095-4dannjjm 1202 14 after after IN cord-023095-4dannjjm 1202 15 exposure exposure NN cord-023095-4dannjjm 1202 16 to to IN cord-023095-4dannjjm 1202 17 hypertonic hypertonic JJ cord-023095-4dannjjm 1202 18 aerosols aerosol NNS cord-023095-4dannjjm 1202 19 ( ( -LRB- cord-023095-4dannjjm 1202 20 5 5 CD cord-023095-4dannjjm 1202 21 minute minute NN cord-023095-4dannjjm 1202 22 nebulization nebulization NN cord-023095-4dannjjm 1202 23 with with IN cord-023095-4dannjjm 1202 24 solutions solution NNS cord-023095-4dannjjm 1202 25 of of IN cord-023095-4dannjjm 1202 26 either either CC cord-023095-4dannjjm 1202 27 isotonic isotonic JJ cord-023095-4dannjjm 1202 28 or or CC cord-023095-4dannjjm 1202 29 hypertonic hypertonic JJ cord-023095-4dannjjm 1202 30 mannitol mannitol NN cord-023095-4dannjjm 1202 31 ) ) -RRB- cord-023095-4dannjjm 1202 32 . . . cord-023095-4dannjjm 1203 1 Airway airway NN cord-023095-4dannjjm 1203 2 leukocytes leukocyte NNS cord-023095-4dannjjm 1203 3 were be VBD cord-023095-4dannjjm 1203 4 harvested harvest VBN cord-023095-4dannjjm 1203 5 5 5 CD cord-023095-4dannjjm 1203 6 and and CC cord-023095-4dannjjm 1203 7 24 24 CD cord-023095-4dannjjm 1203 8 hours hour NNS cord-023095-4dannjjm 1203 9 post post NN cord-023095-4dannjjm 1203 10 aerosol aerosol NN cord-023095-4dannjjm 1203 11 challenge challenge NN cord-023095-4dannjjm 1203 12 via via IN cord-023095-4dannjjm 1203 13 bronchoaveolar bronchoaveolar NNP cord-023095-4dannjjm 1203 14 lavage lavage NN cord-023095-4dannjjm 1203 15 , , , cord-023095-4dannjjm 1203 16 and and CC cord-023095-4dannjjm 1203 17 were be VBD cord-023095-4dannjjm 1203 18 used use VBN cord-023095-4dannjjm 1203 19 to to TO cord-023095-4dannjjm 1203 20 determine determine VB cord-023095-4dannjjm 1203 21 total total JJ cord-023095-4dannjjm 1203 22 and and CC cord-023095-4dannjjm 1203 23 differential differential JJ cord-023095-4dannjjm 1203 24 nucleated nucleated JJ cord-023095-4dannjjm 1203 25 cell cell NN cord-023095-4dannjjm 1203 26 count count NN cord-023095-4dannjjm 1203 27 and and CC cord-023095-4dannjjm 1203 28 expression expression NN cord-023095-4dannjjm 1203 29 of of IN cord-023095-4dannjjm 1203 30 cytokinespecific cytokinespecific NNP cord-023095-4dannjjm 1203 31 mRNA mRNA NNP cord-023095-4dannjjm 1203 32 . . . cord-023095-4dannjjm 1204 1 Hypertonic Hypertonic NNP cord-023095-4dannjjm 1204 2 aerosol aerosol NN cord-023095-4dannjjm 1204 3 challenge challenge NN cord-023095-4dannjjm 1204 4 resulted result VBD cord-023095-4dannjjm 1204 5 in in IN cord-023095-4dannjjm 1204 6 an an DT cord-023095-4dannjjm 1204 7 increase increase NN cord-023095-4dannjjm 1204 8 in in IN cord-023095-4dannjjm 1204 9 total total JJ cord-023095-4dannjjm 1204 10 number number NN cord-023095-4dannjjm 1204 11 of of IN cord-023095-4dannjjm 1204 12 cells cell NNS cord-023095-4dannjjm 1204 13 5 5 CD cord-023095-4dannjjm 1204 14 hr hr NN cord-023095-4dannjjm 1204 15 after after IN cord-023095-4dannjjm 1204 16 challenge challenge NN cord-023095-4dannjjm 1204 17 , , , cord-023095-4dannjjm 1204 18 characterized characterize VBN cord-023095-4dannjjm 1204 19 by by IN cord-023095-4dannjjm 1204 20 increased increase VBN cord-023095-4dannjjm 1204 21 macrophage macrophage NN cord-023095-4dannjjm 1204 22 ( ( -LRB- cord-023095-4dannjjm 1204 23 p p NN cord-023095-4dannjjm 1204 24 5 5 CD cord-023095-4dannjjm 1204 25 0.04 0.04 CD cord-023095-4dannjjm 1204 26 ) ) -RRB- cord-023095-4dannjjm 1204 27 and and CC cord-023095-4dannjjm 1204 28 neutrophil neutrophil NN cord-023095-4dannjjm 1204 29 ( ( -LRB- cord-023095-4dannjjm 1204 30 p p NN cord-023095-4dannjjm 1204 31 5 5 CD cord-023095-4dannjjm 1204 32 0.03 0.03 CD cord-023095-4dannjjm 1204 33 ) ) -RRB- cord-023095-4dannjjm 1204 34 concentrations concentration NNS cord-023095-4dannjjm 1204 35 , , , cord-023095-4dannjjm 1204 36 but but CC cord-023095-4dannjjm 1204 37 there there EX cord-023095-4dannjjm 1204 38 was be VBD cord-023095-4dannjjm 1204 39 no no DT cord-023095-4dannjjm 1204 40 effect effect NN cord-023095-4dannjjm 1204 41 on on IN cord-023095-4dannjjm 1204 42 airway airway NN cord-023095-4dannjjm 1204 43 leukocyte leukocyte NN cord-023095-4dannjjm 1204 44 concentrations concentration NNS cord-023095-4dannjjm 1204 45 24 24 CD cord-023095-4dannjjm 1204 46 hours hour NNS cord-023095-4dannjjm 1204 47 after after IN cord-023095-4dannjjm 1204 48 nebulization nebulization NN cord-023095-4dannjjm 1204 49 . . . cord-023095-4dannjjm 1205 1 No no DT cord-023095-4dannjjm 1205 2 significant significant JJ cord-023095-4dannjjm 1205 3 changes change NNS cord-023095-4dannjjm 1205 4 in in IN cord-023095-4dannjjm 1205 5 the the DT cord-023095-4dannjjm 1205 6 relative relative JJ cord-023095-4dannjjm 1205 7 quantity quantity NN cord-023095-4dannjjm 1205 8 of of IN cord-023095-4dannjjm 1205 9 mRNA mrna NN cord-023095-4dannjjm 1205 10 for for IN cord-023095-4dannjjm 1205 11 airway airway NN cord-023095-4dannjjm 1205 12 cytokines cytokine NNS cord-023095-4dannjjm 1205 13 were be VBD cord-023095-4dannjjm 1205 14 noted note VBN cord-023095-4dannjjm 1205 15 at at IN cord-023095-4dannjjm 1205 16 either either DT cord-023095-4dannjjm 1205 17 time time NN cord-023095-4dannjjm 1205 18 point point NN cord-023095-4dannjjm 1205 19 . . . cord-023095-4dannjjm 1206 1 These these DT cord-023095-4dannjjm 1206 2 data datum NNS cord-023095-4dannjjm 1206 3 demonstrate demonstrate VBP cord-023095-4dannjjm 1206 4 that that IN cord-023095-4dannjjm 1206 5 transient transient JJ cord-023095-4dannjjm 1206 6 airway airway NN cord-023095-4dannjjm 1206 7 hypertonicity hypertonicity NN cord-023095-4dannjjm 1206 8 can can MD cord-023095-4dannjjm 1206 9 cause cause VB cord-023095-4dannjjm 1206 10 airway airway NN cord-023095-4dannjjm 1206 11 leukocyte leukocyte NN cord-023095-4dannjjm 1206 12 influx influx NN cord-023095-4dannjjm 1206 13 and and CC cord-023095-4dannjjm 1206 14 may may MD cord-023095-4dannjjm 1206 15 be be VB cord-023095-4dannjjm 1206 16 responsible responsible JJ cord-023095-4dannjjm 1206 17 for for IN cord-023095-4dannjjm 1206 18 the the DT cord-023095-4dannjjm 1206 19 airway airway NN cord-023095-4dannjjm 1206 20 inflammation inflammation NN cord-023095-4dannjjm 1206 21 commonly commonly RB cord-023095-4dannjjm 1206 22 found find VBN cord-023095-4dannjjm 1206 23 in in IN cord-023095-4dannjjm 1206 24 athletes athlete NNS cord-023095-4dannjjm 1206 25 that that WDT cord-023095-4dannjjm 1206 26 exercise exercise VBP cord-023095-4dannjjm 1206 27 in in IN cord-023095-4dannjjm 1206 28 cold cold JJ cord-023095-4dannjjm 1206 29 conditions condition NNS cord-023095-4dannjjm 1206 30 . . . cord-023095-4dannjjm 1207 1 However however RB cord-023095-4dannjjm 1207 2 , , , cord-023095-4dannjjm 1207 3 our -PRON- PRP$ cord-023095-4dannjjm 1207 4 data datum NNS cord-023095-4dannjjm 1207 5 do do VBP cord-023095-4dannjjm 1207 6 not not RB cord-023095-4dannjjm 1207 7 support support VB cord-023095-4dannjjm 1207 8 the the DT cord-023095-4dannjjm 1207 9 hypothesis hypothesis NN cord-023095-4dannjjm 1207 10 that that IN cord-023095-4dannjjm 1207 11 hypertonicity hypertonicity NN cord-023095-4dannjjm 1207 12 is be VBZ cord-023095-4dannjjm 1207 13 the the DT cord-023095-4dannjjm 1207 14 sole sole JJ cord-023095-4dannjjm 1207 15 initiating initiate VBG cord-023095-4dannjjm 1207 16 cause cause NN cord-023095-4dannjjm 1207 17 of of IN cord-023095-4dannjjm 1207 18 changes change NNS cord-023095-4dannjjm 1207 19 in in IN cord-023095-4dannjjm 1207 20 cytokine cytokine JJ cord-023095-4dannjjm 1207 21 expression expression NN cord-023095-4dannjjm 1207 22 secondary secondary JJ cord-023095-4dannjjm 1207 23 to to IN cord-023095-4dannjjm 1207 24 cold cold JJ cord-023095-4dannjjm 1207 25 weather weather NN cord-023095-4dannjjm 1207 26 exercise exercise NN cord-023095-4dannjjm 1207 27 . . . cord-023095-4dannjjm 1208 1 It -PRON- PRP cord-023095-4dannjjm 1208 2 is be VBZ cord-023095-4dannjjm 1208 3 likely likely JJ cord-023095-4dannjjm 1208 4 that that IN cord-023095-4dannjjm 1208 5 factors factor NNS cord-023095-4dannjjm 1208 6 such such JJ cord-023095-4dannjjm 1208 7 as as IN cord-023095-4dannjjm 1208 8 airway airway NN cord-023095-4dannjjm 1208 9 temperature temperature NN cord-023095-4dannjjm 1208 10 , , , cord-023095-4dannjjm 1208 11 shear shear NN cord-023095-4dannjjm 1208 12 stress stress NN cord-023095-4dannjjm 1208 13 or or CC cord-023095-4dannjjm 1208 14 epithelial epithelial JJ cord-023095-4dannjjm 1208 15 damage damage NN cord-023095-4dannjjm 1208 16 also also RB cord-023095-4dannjjm 1208 17 play play VBP cord-023095-4dannjjm 1208 18 a a DT cord-023095-4dannjjm 1208 19 role role NN cord-023095-4dannjjm 1208 20 in in IN cord-023095-4dannjjm 1208 21 this this DT cord-023095-4dannjjm 1208 22 phenomenon phenomenon NN cord-023095-4dannjjm 1208 23 . . . cord-023095-4dannjjm 1209 1 We -PRON- PRP cord-023095-4dannjjm 1209 2 studied study VBD cord-023095-4dannjjm 1209 3 the the DT cord-023095-4dannjjm 1209 4 importance importance NN cord-023095-4dannjjm 1209 5 of of IN cord-023095-4dannjjm 1209 6 abdominal abdominal JJ cord-023095-4dannjjm 1209 7 sonograms sonogram NNS cord-023095-4dannjjm 1209 8 in in IN cord-023095-4dannjjm 1209 9 neonatal neonatal JJ cord-023095-4dannjjm 1209 10 foals foal NNS cord-023095-4dannjjm 1209 11 suffering suffer VBG cord-023095-4dannjjm 1209 12 from from IN cord-023095-4dannjjm 1209 13 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1209 14 conditions condition NNS cord-023095-4dannjjm 1209 15 . . . cord-023095-4dannjjm 1210 1 We -PRON- PRP cord-023095-4dannjjm 1210 2 hypothesized hypothesize VBD cord-023095-4dannjjm 1210 3 that that IN cord-023095-4dannjjm 1210 4 there there EX cord-023095-4dannjjm 1210 5 would would MD cord-023095-4dannjjm 1210 6 be be VB cord-023095-4dannjjm 1210 7 a a DT cord-023095-4dannjjm 1210 8 subgroup subgroup NN cord-023095-4dannjjm 1210 9 of of IN cord-023095-4dannjjm 1210 10 neonates neonate NNS cord-023095-4dannjjm 1210 11 with with IN cord-023095-4dannjjm 1210 12 sonographically sonographically RB cord-023095-4dannjjm 1210 13 detectable detectable JJ cord-023095-4dannjjm 1210 14 pneumatosis pneumatosis NN cord-023095-4dannjjm 1210 15 intestinalis intestinalis FW cord-023095-4dannjjm 1210 16 ( ( -LRB- cord-023095-4dannjjm 1210 17 PI PI NNP cord-023095-4dannjjm 1210 18 ) ) -RRB- cord-023095-4dannjjm 1210 19 as as IN cord-023095-4dannjjm 1210 20 a a DT cord-023095-4dannjjm 1210 21 reflection reflection NN cord-023095-4dannjjm 1210 22 of of IN cord-023095-4dannjjm 1210 23 a a DT cord-023095-4dannjjm 1210 24 necrotizing necrotize VBG cord-023095-4dannjjm 1210 25 component component NN cord-023095-4dannjjm 1210 26 of of IN cord-023095-4dannjjm 1210 27 the the DT cord-023095-4dannjjm 1210 28 disease disease NN cord-023095-4dannjjm 1210 29 . . . cord-023095-4dannjjm 1211 1 Records record NNS cord-023095-4dannjjm 1211 2 of of IN cord-023095-4dannjjm 1211 3 foals foal NNS cord-023095-4dannjjm 1211 4 7 7 CD cord-023095-4dannjjm 1211 5 days day NNS cord-023095-4dannjjm 1211 6 of of IN cord-023095-4dannjjm 1211 7 age age NN cord-023095-4dannjjm 1211 8 hospitalized hospitalize VBN cord-023095-4dannjjm 1211 9 between between IN cord-023095-4dannjjm 1211 10 2005 2005 CD cord-023095-4dannjjm 1211 11 and and CC cord-023095-4dannjjm 1211 12 2009 2009 CD cord-023095-4dannjjm 1211 13 with with IN cord-023095-4dannjjm 1211 14 signs sign NNS cord-023095-4dannjjm 1211 15 of of IN cord-023095-4dannjjm 1211 16 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1211 17 disease disease NN cord-023095-4dannjjm 1211 18 were be VBD cord-023095-4dannjjm 1211 19 evaluated evaluate VBN cord-023095-4dannjjm 1211 20 ( ( -LRB- cord-023095-4dannjjm 1211 21 N N NNP cord-023095-4dannjjm 1211 22 5 5 CD cord-023095-4dannjjm 1211 23 89 89 CD cord-023095-4dannjjm 1211 24 ) ) -RRB- cord-023095-4dannjjm 1211 25 . . . cord-023095-4dannjjm 1212 1 The the DT cord-023095-4dannjjm 1212 2 association association NN cord-023095-4dannjjm 1212 3 of of IN cord-023095-4dannjjm 1212 4 sonographic sonographic NNP cord-023095-4dannjjm 1212 5 , , , cord-023095-4dannjjm 1212 6 clinical clinical JJ cord-023095-4dannjjm 1212 7 , , , cord-023095-4dannjjm 1212 8 pathological pathological JJ cord-023095-4dannjjm 1212 9 and and CC cord-023095-4dannjjm 1212 10 clinicopathological clinicopathological JJ cord-023095-4dannjjm 1212 11 signs sign NNS cord-023095-4dannjjm 1212 12 with with IN cord-023095-4dannjjm 1212 13 outcome outcome NN cord-023095-4dannjjm 1212 14 and and CC cord-023095-4dannjjm 1212 15 severity severity NN cord-023095-4dannjjm 1212 16 of of IN cord-023095-4dannjjm 1212 17 disease disease NN cord-023095-4dannjjm 1212 18 was be VBD cord-023095-4dannjjm 1212 19 determined determine VBN cord-023095-4dannjjm 1212 20 . . . cord-023095-4dannjjm 1213 1 Pneumatosis Pneumatosis NNP cord-023095-4dannjjm 1213 2 intestinalis intestinalis NNP cord-023095-4dannjjm 1213 3 was be VBD cord-023095-4dannjjm 1213 4 imaged image VBN cord-023095-4dannjjm 1213 5 in in IN cord-023095-4dannjjm 1213 6 19 19 CD cord-023095-4dannjjm 1213 7 foals foal NNS cord-023095-4dannjjm 1213 8 . . . cord-023095-4dannjjm 1214 1 Twenty twenty CD cord-023095-4dannjjm 1214 2 - - HYPH cord-023095-4dannjjm 1214 3 seven seven CD cord-023095-4dannjjm 1214 4 foals foal NNS cord-023095-4dannjjm 1214 5 were be VBD cord-023095-4dannjjm 1214 6 classified classify VBN cord-023095-4dannjjm 1214 7 as as IN cord-023095-4dannjjm 1214 8 having have VBG cord-023095-4dannjjm 1214 9 necrotizing necrotize VBG cord-023095-4dannjjm 1214 10 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1214 11 disease disease NN cord-023095-4dannjjm 1214 12 based base VBN cord-023095-4dannjjm 1214 13 on on IN cord-023095-4dannjjm 1214 14 the the DT cord-023095-4dannjjm 1214 15 presence presence NN cord-023095-4dannjjm 1214 16 of of IN cord-023095-4dannjjm 1214 17 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1214 18 signs sign NNS cord-023095-4dannjjm 1214 19 ( ( -LRB- cord-023095-4dannjjm 1214 20 colic colic NN cord-023095-4dannjjm 1214 21 , , , cord-023095-4dannjjm 1214 22 diarrhea diarrhea NN cord-023095-4dannjjm 1214 23 , , , cord-023095-4dannjjm 1214 24 gastric gastric JJ cord-023095-4dannjjm 1214 25 reflux reflux NN cord-023095-4dannjjm 1214 26 or or CC cord-023095-4dannjjm 1214 27 abdominal abdominal JJ cord-023095-4dannjjm 1214 28 distension distension NN cord-023095-4dannjjm 1214 29 ) ) -RRB- cord-023095-4dannjjm 1214 30 and and CC cord-023095-4dannjjm 1214 31 PI PI NNP cord-023095-4dannjjm 1214 32 detected detect VBD cord-023095-4dannjjm 1214 33 sonographically sonographically RB cord-023095-4dannjjm 1214 34 ( ( -LRB- cord-023095-4dannjjm 1214 35 19 19 CD cord-023095-4dannjjm 1214 36 ) ) -RRB- cord-023095-4dannjjm 1214 37 , , , cord-023095-4dannjjm 1214 38 surgical surgical JJ cord-023095-4dannjjm 1214 39 ( ( -LRB- cord-023095-4dannjjm 1214 40 2 2 CD cord-023095-4dannjjm 1214 41 ) ) -RRB- cord-023095-4dannjjm 1214 42 or or CC cord-023095-4dannjjm 1214 43 pathological pathological JJ cord-023095-4dannjjm 1214 44 ( ( -LRB- cord-023095-4dannjjm 1214 45 6 6 CD cord-023095-4dannjjm 1214 46 ) ) -RRB- cord-023095-4dannjjm 1214 47 evidence evidence NN cord-023095-4dannjjm 1214 48 of of IN cord-023095-4dannjjm 1214 49 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1214 50 necrosis necrosis NN cord-023095-4dannjjm 1214 51 . . . cord-023095-4dannjjm 1215 1 There there EX cord-023095-4dannjjm 1215 2 was be VBD cord-023095-4dannjjm 1215 3 a a DT cord-023095-4dannjjm 1215 4 difference difference NN cord-023095-4dannjjm 1215 5 between between IN cord-023095-4dannjjm 1215 6 overall overall JJ cord-023095-4dannjjm 1215 7 survival survival NN cord-023095-4dannjjm 1215 8 rate rate NN cord-023095-4dannjjm 1215 9 ( ( -LRB- cord-023095-4dannjjm 1215 10 58 58 CD cord-023095-4dannjjm 1215 11 % % NN cord-023095-4dannjjm 1215 12 ) ) -RRB- cord-023095-4dannjjm 1215 13 and and CC cord-023095-4dannjjm 1215 14 survival survival NN cord-023095-4dannjjm 1215 15 rate rate NN cord-023095-4dannjjm 1215 16 in in IN cord-023095-4dannjjm 1215 17 foals foal NNS cord-023095-4dannjjm 1215 18 with with IN cord-023095-4dannjjm 1215 19 necrotizing necrotize VBG cord-023095-4dannjjm 1215 20 disease disease NN cord-023095-4dannjjm 1215 21 ( ( -LRB- cord-023095-4dannjjm 1215 22 33 33 CD cord-023095-4dannjjm 1215 23 % % NN cord-023095-4dannjjm 1215 24 , , , cord-023095-4dannjjm 1215 25 P p NN cord-023095-4dannjjm 1215 26 5 5 CD cord-023095-4dannjjm 1215 27 0.005 0.005 CD cord-023095-4dannjjm 1215 28 ) ) -RRB- cord-023095-4dannjjm 1215 29 or or CC cord-023095-4dannjjm 1215 30 foals foal NNS cord-023095-4dannjjm 1215 31 with with IN cord-023095-4dannjjm 1215 32 PI PI NNP cord-023095-4dannjjm 1215 33 detected detect VBN cord-023095-4dannjjm 1215 34 sonographically sonographically RB cord-023095-4dannjjm 1215 35 ( ( -LRB- cord-023095-4dannjjm 1215 36 37 37 CD cord-023095-4dannjjm 1215 37 % % NN cord-023095-4dannjjm 1215 38 , , , cord-023095-4dannjjm 1215 39 P p NN cord-023095-4dannjjm 1215 40 5 5 CD cord-023095-4dannjjm 1215 41 0.02 0.02 CD cord-023095-4dannjjm 1215 42 ) ) -RRB- cord-023095-4dannjjm 1215 43 . . . cord-023095-4dannjjm 1216 1 Pneumatosis Pneumatosis NNP cord-023095-4dannjjm 1216 2 intestinalis intestinalis NNP cord-023095-4dannjjm 1216 3 was be VBD cord-023095-4dannjjm 1216 4 the the DT cord-023095-4dannjjm 1216 5 only only JJ cord-023095-4dannjjm 1216 6 sonographic sonographic JJ cord-023095-4dannjjm 1216 7 finding finding NN cord-023095-4dannjjm 1216 8 associated associate VBN cord-023095-4dannjjm 1216 9 with with IN cord-023095-4dannjjm 1216 10 outcome outcome NN cord-023095-4dannjjm 1216 11 . . . cord-023095-4dannjjm 1217 1 Sonographic sonographic JJ cord-023095-4dannjjm 1217 2 abnormalities abnormality NNS cord-023095-4dannjjm 1217 3 in in IN cord-023095-4dannjjm 1217 4 peritoneal peritoneal JJ cord-023095-4dannjjm 1217 5 fluid fluid NN cord-023095-4dannjjm 1217 6 , , , cord-023095-4dannjjm 1217 7 stomach stomach NN cord-023095-4dannjjm 1217 8 , , , cord-023095-4dannjjm 1217 9 duodenum duodenum NN cord-023095-4dannjjm 1217 10 , , , cord-023095-4dannjjm 1217 11 jejunum jejunum NN cord-023095-4dannjjm 1217 12 , , , cord-023095-4dannjjm 1217 13 cecum cecum NN cord-023095-4dannjjm 1217 14 , , , cord-023095-4dannjjm 1217 15 umbilicus umbilicus NN cord-023095-4dannjjm 1217 16 or or CC cord-023095-4dannjjm 1217 17 the the DT cord-023095-4dannjjm 1217 18 presence presence NN cord-023095-4dannjjm 1217 19 of of IN cord-023095-4dannjjm 1217 20 meconium meconium NN cord-023095-4dannjjm 1217 21 were be VBD cord-023095-4dannjjm 1217 22 associated associate VBN cord-023095-4dannjjm 1217 23 ( ( -LRB- cord-023095-4dannjjm 1217 24 P p NN cord-023095-4dannjjm 1217 25 o o NN cord-023095-4dannjjm 1217 26 0.05 0.05 CD cord-023095-4dannjjm 1217 27 ) ) -RRB- cord-023095-4dannjjm 1217 28 with with IN cord-023095-4dannjjm 1217 29 surrogates surrogate NNS cord-023095-4dannjjm 1217 30 of of IN cord-023095-4dannjjm 1217 31 severity severity NN cord-023095-4dannjjm 1217 32 of of IN cord-023095-4dannjjm 1217 33 disease disease NN cord-023095-4dannjjm 1217 34 ( ( -LRB- cord-023095-4dannjjm 1217 35 hospitalization hospitalization NN cord-023095-4dannjjm 1217 36 cost cost NN cord-023095-4dannjjm 1217 37 or or CC cord-023095-4dannjjm 1217 38 days day NNS cord-023095-4dannjjm 1217 39 of of IN cord-023095-4dannjjm 1217 40 hospitalization hospitalization NN cord-023095-4dannjjm 1217 41 ) ) -RRB- cord-023095-4dannjjm 1217 42 . . . cord-023095-4dannjjm 1218 1 Hypoproteinemia Hypoproteinemia NNP cord-023095-4dannjjm 1218 2 was be VBD cord-023095-4dannjjm 1218 3 associated associate VBN cord-023095-4dannjjm 1218 4 with with IN cord-023095-4dannjjm 1218 5 PI pi NN cord-023095-4dannjjm 1218 6 ( ( -LRB- cord-023095-4dannjjm 1218 7 P p NN cord-023095-4dannjjm 1218 8 5 5 CD cord-023095-4dannjjm 1218 9 0.02 0.02 CD cord-023095-4dannjjm 1218 10 ) ) -RRB- cord-023095-4dannjjm 1218 11 . . . cord-023095-4dannjjm 1219 1 The the DT cord-023095-4dannjjm 1219 2 presence presence NN cord-023095-4dannjjm 1219 3 of of IN cord-023095-4dannjjm 1219 4 blood blood NN cord-023095-4dannjjm 1219 5 in in IN cord-023095-4dannjjm 1219 6 the the DT cord-023095-4dannjjm 1219 7 feces fece NNS cord-023095-4dannjjm 1219 8 , , , cord-023095-4dannjjm 1219 9 reflux reflux NN cord-023095-4dannjjm 1219 10 and and CC cord-023095-4dannjjm 1219 11 abdominal abdominal JJ cord-023095-4dannjjm 1219 12 distension distension NN cord-023095-4dannjjm 1219 13 was be VBD cord-023095-4dannjjm 1219 14 associated associate VBN cord-023095-4dannjjm 1219 15 with with IN cord-023095-4dannjjm 1219 16 necrotizing necrotize VBG cord-023095-4dannjjm 1219 17 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1219 18 disease disease NN cord-023095-4dannjjm 1219 19 ( ( -LRB- cord-023095-4dannjjm 1219 20 P p NN cord-023095-4dannjjm 1219 21 o o NN cord-023095-4dannjjm 1219 22 0.05 0.05 CD cord-023095-4dannjjm 1219 23 ) ) -RRB- cord-023095-4dannjjm 1219 24 . . . cord-023095-4dannjjm 1220 1 Abdominal abdominal JJ cord-023095-4dannjjm 1220 2 sonograms sonogram NNS cord-023095-4dannjjm 1220 3 have have VBP cord-023095-4dannjjm 1220 4 prognostic prognostic JJ cord-023095-4dannjjm 1220 5 value value NN cord-023095-4dannjjm 1220 6 in in IN cord-023095-4dannjjm 1220 7 neonatal neonatal JJ cord-023095-4dannjjm 1220 8 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1220 9 disease disease NN cord-023095-4dannjjm 1220 10 . . . cord-023095-4dannjjm 1221 1 Pneumatosis Pneumatosis NNP cord-023095-4dannjjm 1221 2 intestinalis intestinalis NNP cord-023095-4dannjjm 1221 3 was be VBD cord-023095-4dannjjm 1221 4 a a DT cord-023095-4dannjjm 1221 5 common common JJ cord-023095-4dannjjm 1221 6 sonographic sonographic JJ cord-023095-4dannjjm 1221 7 sign sign NN cord-023095-4dannjjm 1221 8 that that WDT cord-023095-4dannjjm 1221 9 worsened worsen VBD cord-023095-4dannjjm 1221 10 the the DT cord-023095-4dannjjm 1221 11 prognosis prognosis NN cord-023095-4dannjjm 1221 12 . . . cord-023095-4dannjjm 1222 1 The the DT cord-023095-4dannjjm 1222 2 therapeutic therapeutic JJ cord-023095-4dannjjm 1222 3 implications implication NNS cord-023095-4dannjjm 1222 4 of of IN cord-023095-4dannjjm 1222 5 detecting detect VBG cord-023095-4dannjjm 1222 6 a a DT cord-023095-4dannjjm 1222 7 necrotizing necrotize VBG cord-023095-4dannjjm 1222 8 component component NN cord-023095-4dannjjm 1222 9 of of IN cord-023095-4dannjjm 1222 10 the the DT cord-023095-4dannjjm 1222 11 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1222 12 disease disease NN cord-023095-4dannjjm 1222 13 deserve deserve VBP cord-023095-4dannjjm 1222 14 further further JJ cord-023095-4dannjjm 1222 15 study study NN cord-023095-4dannjjm 1222 16 . . . cord-023095-4dannjjm 1223 1 The the DT cord-023095-4dannjjm 1223 2 interaction interaction NN cord-023095-4dannjjm 1223 3 of of IN cord-023095-4dannjjm 1223 4 insulin insulin NN cord-023095-4dannjjm 1223 5 and and CC cord-023095-4dannjjm 1223 6 the the DT cord-023095-4dannjjm 1223 7 microvascular microvascular JJ cord-023095-4dannjjm 1223 8 endothelial endothelial JJ cord-023095-4dannjjm 1223 9 insulin insulin NN cord-023095-4dannjjm 1223 10 receptor receptor NN cord-023095-4dannjjm 1223 11 ( ( -LRB- cord-023095-4dannjjm 1223 12 IRc IRc NNP cord-023095-4dannjjm 1223 13 ) ) -RRB- cord-023095-4dannjjm 1223 14 plays play VBZ cord-023095-4dannjjm 1223 15 an an DT cord-023095-4dannjjm 1223 16 important important JJ cord-023095-4dannjjm 1223 17 role role NN cord-023095-4dannjjm 1223 18 in in IN cord-023095-4dannjjm 1223 19 the the DT cord-023095-4dannjjm 1223 20 normal normal JJ cord-023095-4dannjjm 1223 21 and and CC cord-023095-4dannjjm 1223 22 insulin insulin NN cord-023095-4dannjjm 1223 23 resistant resistant JJ cord-023095-4dannjjm 1223 24 ( ( -LRB- cord-023095-4dannjjm 1223 25 IR IR NNP cord-023095-4dannjjm 1223 26 ) ) -RRB- cord-023095-4dannjjm 1223 27 individual individual NN cord-023095-4dannjjm 1223 28 . . . cord-023095-4dannjjm 1224 1 While while IN cord-023095-4dannjjm 1224 2 endothelial endothelial JJ cord-023095-4dannjjm 1224 3 IRc irc NN cord-023095-4dannjjm 1224 4 signaling signaling NN cord-023095-4dannjjm 1224 5 is be VBZ cord-023095-4dannjjm 1224 6 normally normally RB cord-023095-4dannjjm 1224 7 vasodilatory vasodilatory NN cord-023095-4dannjjm 1224 8 , , , cord-023095-4dannjjm 1224 9 this this DT cord-023095-4dannjjm 1224 10 effect effect NN cord-023095-4dannjjm 1224 11 is be VBZ cord-023095-4dannjjm 1224 12 well well RB cord-023095-4dannjjm 1224 13 - - HYPH cord-023095-4dannjjm 1224 14 documented document VBN cord-023095-4dannjjm 1224 15 to to TO cord-023095-4dannjjm 1224 16 reverse reverse VB cord-023095-4dannjjm 1224 17 in in IN cord-023095-4dannjjm 1224 18 the the DT cord-023095-4dannjjm 1224 19 IR IR NNP cord-023095-4dannjjm 1224 20 individual individual NN cord-023095-4dannjjm 1224 21 , , , cord-023095-4dannjjm 1224 22 resulting result VBG cord-023095-4dannjjm 1224 23 in in IN cord-023095-4dannjjm 1224 24 vasoconstriction vasoconstriction NN cord-023095-4dannjjm 1224 25 . . . cord-023095-4dannjjm 1225 1 Although although IN cord-023095-4dannjjm 1225 2 vascular vascular JJ cord-023095-4dannjjm 1225 3 dysfunction dysfunction NN cord-023095-4dannjjm 1225 4 has have VBZ cord-023095-4dannjjm 1225 5 been be VBN cord-023095-4dannjjm 1225 6 reported report VBN cord-023095-4dannjjm 1225 7 in in IN cord-023095-4dannjjm 1225 8 sepsis sepsis NN cord-023095-4dannjjm 1225 9 - - HYPH cord-023095-4dannjjm 1225 10 associated associate VBN cord-023095-4dannjjm 1225 11 equine equine NN cord-023095-4dannjjm 1225 12 laminitis laminitis NN cord-023095-4dannjjm 1225 13 , , , cord-023095-4dannjjm 1225 14 the the DT cord-023095-4dannjjm 1225 15 role role NN cord-023095-4dannjjm 1225 16 of of IN cord-023095-4dannjjm 1225 17 the the DT cord-023095-4dannjjm 1225 18 laminar laminar JJ cord-023095-4dannjjm 1225 19 microvasculature microvasculature NN cord-023095-4dannjjm 1225 20 in in IN cord-023095-4dannjjm 1225 21 endocrinopathic endocrinopathic NNP cord-023095-4dannjjm 1225 22 laminitis laminitis NN cord-023095-4dannjjm 1225 23 remains remain VBZ cord-023095-4dannjjm 1225 24 poorly poorly RB cord-023095-4dannjjm 1225 25 characterized characterize VBN cord-023095-4dannjjm 1225 26 . . . cord-023095-4dannjjm 1226 1 The the DT cord-023095-4dannjjm 1226 2 purpose purpose NN cord-023095-4dannjjm 1226 3 of of IN cord-023095-4dannjjm 1226 4 this this DT cord-023095-4dannjjm 1226 5 study study NN cord-023095-4dannjjm 1226 6 was be VBD cord-023095-4dannjjm 1226 7 to to TO cord-023095-4dannjjm 1226 8 characterize characterize VB cord-023095-4dannjjm 1226 9 the the DT cord-023095-4dannjjm 1226 10 pattern pattern NN cord-023095-4dannjjm 1226 11 of of IN cord-023095-4dannjjm 1226 12 IRc irc JJ cord-023095-4dannjjm 1226 13 expression expression NN cord-023095-4dannjjm 1226 14 in in IN cord-023095-4dannjjm 1226 15 digital digital JJ cord-023095-4dannjjm 1226 16 laminae laminae NNP cord-023095-4dannjjm 1226 17 in in IN cord-023095-4dannjjm 1226 18 ponies pony NNS cord-023095-4dannjjm 1226 19 subjected subject VBN cord-023095-4dannjjm 1226 20 to to IN cord-023095-4dannjjm 1226 21 a a DT cord-023095-4dannjjm 1226 22 dietary dietary JJ cord-023095-4dannjjm 1226 23 carbohydrate carbohydrate NN cord-023095-4dannjjm 1226 24 challenge challenge NN cord-023095-4dannjjm 1226 25 that that WDT cord-023095-4dannjjm 1226 26 mimicked mimic VBD cord-023095-4dannjjm 1226 27 abrupt abrupt JJ cord-023095-4dannjjm 1226 28 exposure exposure NN cord-023095-4dannjjm 1226 29 to to TO cord-023095-4dannjjm 1226 30 pasture pasture VB cord-023095-4dannjjm 1226 31 rich rich JJ cord-023095-4dannjjm 1226 32 in in IN cord-023095-4dannjjm 1226 33 nonstructural nonstructural JJ cord-023095-4dannjjm 1226 34 carbohydrates carbohydrate NNS cord-023095-4dannjjm 1226 35 ( ( -LRB- cord-023095-4dannjjm 1226 36 NSC NSC NNP cord-023095-4dannjjm 1226 37 ) ) -RRB- cord-023095-4dannjjm 1226 38 . . . cord-023095-4dannjjm 1227 1 Mixed mixed JJ cord-023095-4dannjjm 1227 2 - - HYPH cord-023095-4dannjjm 1227 3 breed breed NN cord-023095-4dannjjm 1227 4 ponies pony NNS cord-023095-4dannjjm 1227 5 ( ( -LRB- cord-023095-4dannjjm 1227 6 body body NN cord-023095-4dannjjm 1227 7 weight weight NN cord-023095-4dannjjm 1227 8 270.9 270.9 CD cord-023095-4dannjjm 1227 9 1/-74.4 1/-74.4 CD cord-023095-4dannjjm 1227 10 kg kg NNS cord-023095-4dannjjm 1227 11 ) ) -RRB- cord-023095-4dannjjm 1227 12 received receive VBD cord-023095-4dannjjm 1227 13 a a DT cord-023095-4dannjjm 1227 14 diet diet NN cord-023095-4dannjjm 1227 15 of of IN cord-023095-4dannjjm 1227 16 hay hay NN cord-023095-4dannjjm 1227 17 chop chop NN cord-023095-4dannjjm 1227 18 ( ( -LRB- cord-023095-4dannjjm 1227 19 NSC NSC NNP cord-023095-4dannjjm 1227 20 $ $ $ cord-023095-4dannjjm 1227 21 6 6 CD cord-023095-4dannjjm 1227 22 % % NN cord-023095-4dannjjm 1227 23 on on IN cord-023095-4dannjjm 1227 24 a a DT cord-023095-4dannjjm 1227 25 DM dm NN cord-023095-4dannjjm 1227 26 basis basis NN cord-023095-4dannjjm 1227 27 ) ) -RRB- cord-023095-4dannjjm 1227 28 for for IN cord-023095-4dannjjm 1227 29 4 4 CD cord-023095-4dannjjm 1227 30 weeks week NNS cord-023095-4dannjjm 1227 31 prior prior RB cord-023095-4dannjjm 1227 32 to to IN cord-023095-4dannjjm 1227 33 initiation initiation NN cord-023095-4dannjjm 1227 34 of of IN cord-023095-4dannjjm 1227 35 the the DT cord-023095-4dannjjm 1227 36 experimental experimental JJ cord-023095-4dannjjm 1227 37 feeding feeding NN cord-023095-4dannjjm 1227 38 protocol protocol NN cord-023095-4dannjjm 1227 39 . . . cord-023095-4dannjjm 1228 1 Following follow VBG cord-023095-4dannjjm 1228 2 conditioning conditioning NN cord-023095-4dannjjm 1228 3 , , , cord-023095-4dannjjm 1228 4 ponies pony NNS cord-023095-4dannjjm 1228 5 either either CC cord-023095-4dannjjm 1228 6 remained remain VBD cord-023095-4dannjjm 1228 7 on on IN cord-023095-4dannjjm 1228 8 the the DT cord-023095-4dannjjm 1228 9 control control NN cord-023095-4dannjjm 1228 10 diet diet NN cord-023095-4dannjjm 1228 11 ( ( -LRB- cord-023095-4dannjjm 1228 12 n n NN cord-023095-4dannjjm 1228 13 5 5 CD cord-023095-4dannjjm 1228 14 11 11 CD cord-023095-4dannjjm 1228 15 ) ) -RRB- cord-023095-4dannjjm 1228 16 or or CC cord-023095-4dannjjm 1228 17 received receive VBD cord-023095-4dannjjm 1228 18 the the DT cord-023095-4dannjjm 1228 19 same same JJ cord-023095-4dannjjm 1228 20 diet diet NN cord-023095-4dannjjm 1228 21 supplemented supplement VBN cord-023095-4dannjjm 1228 22 with with IN cord-023095-4dannjjm 1228 23 sweet sweet JJ cord-023095-4dannjjm 1228 24 feed feed NN cord-023095-4dannjjm 1228 25 and and CC cord-023095-4dannjjm 1228 26 oligofructose oligofructose JJ cord-023095-4dannjjm 1228 27 ( ( -LRB- cord-023095-4dannjjm 1228 28 total total JJ cord-023095-4dannjjm 1228 29 diet diet NN cord-023095-4dannjjm 1228 30 $ $ $ cord-023095-4dannjjm 1228 31 42 42 CD cord-023095-4dannjjm 1228 32 % % NN cord-023095-4dannjjm 1228 33 NSC NSC NNP cord-023095-4dannjjm 1228 34 ; ; : cord-023095-4dannjjm 1228 35 n n NN cord-023095-4dannjjm 1228 36 5 5 CD cord-023095-4dannjjm 1228 37 11 11 CD cord-023095-4dannjjm 1228 38 ) ) -RRB- cord-023095-4dannjjm 1228 39 for for IN cord-023095-4dannjjm 1228 40 a a DT cord-023095-4dannjjm 1228 41 period period NN cord-023095-4dannjjm 1228 42 of of IN cord-023095-4dannjjm 1228 43 7 7 CD cord-023095-4dannjjm 1228 44 days day NNS cord-023095-4dannjjm 1228 45 . . . cord-023095-4dannjjm 1229 1 Serum serum NN cord-023095-4dannjjm 1229 2 insulin insulin NN cord-023095-4dannjjm 1229 3 concentrations concentration NNS cord-023095-4dannjjm 1229 4 were be VBD cord-023095-4dannjjm 1229 5 measured measure VBN cord-023095-4dannjjm 1229 6 prior prior RB cord-023095-4dannjjm 1229 7 to to IN cord-023095-4dannjjm 1229 8 and and CC cord-023095-4dannjjm 1229 9 after after IN cord-023095-4dannjjm 1229 10 completion completion NN cord-023095-4dannjjm 1229 11 of of IN cord-023095-4dannjjm 1229 12 the the DT cord-023095-4dannjjm 1229 13 feeding feeding NN cord-023095-4dannjjm 1229 14 protocol protocol NN cord-023095-4dannjjm 1229 15 . . . cord-023095-4dannjjm 1230 1 At at IN cord-023095-4dannjjm 1230 2 the the DT cord-023095-4dannjjm 1230 3 end end NN cord-023095-4dannjjm 1230 4 of of IN cord-023095-4dannjjm 1230 5 the the DT cord-023095-4dannjjm 1230 6 feeding feeding NN cord-023095-4dannjjm 1230 7 protocol protocol NN cord-023095-4dannjjm 1230 8 , , , cord-023095-4dannjjm 1230 9 sections section NNS cord-023095-4dannjjm 1230 10 of of IN cord-023095-4dannjjm 1230 11 numerous numerous JJ cord-023095-4dannjjm 1230 12 tissues tissue NNS cord-023095-4dannjjm 1230 13 , , , cord-023095-4dannjjm 1230 14 including include VBG cord-023095-4dannjjm 1230 15 dorsal dorsal JJ cord-023095-4dannjjm 1230 16 digital digital JJ cord-023095-4dannjjm 1230 17 laminae laminae NN cord-023095-4dannjjm 1230 18 , , , cord-023095-4dannjjm 1230 19 were be VBD cord-023095-4dannjjm 1230 20 collected collect VBN cord-023095-4dannjjm 1230 21 immediately immediately RB cord-023095-4dannjjm 1230 22 following follow VBG cord-023095-4dannjjm 1230 23 euthanasia euthanasia NN cord-023095-4dannjjm 1230 24 . . . cord-023095-4dannjjm 1231 1 The the DT cord-023095-4dannjjm 1231 2 samples sample NNS cord-023095-4dannjjm 1231 3 were be VBD cord-023095-4dannjjm 1231 4 formalin formalin NN cord-023095-4dannjjm 1231 5 - - HYPH cord-023095-4dannjjm 1231 6 fixed fix VBN cord-023095-4dannjjm 1231 7 for for IN cord-023095-4dannjjm 1231 8 48 48 CD cord-023095-4dannjjm 1231 9 hours hour NNS cord-023095-4dannjjm 1231 10 , , , cord-023095-4dannjjm 1231 11 transferred transfer VBN cord-023095-4dannjjm 1231 12 to to IN cord-023095-4dannjjm 1231 13 70 70 CD cord-023095-4dannjjm 1231 14 % % NN cord-023095-4dannjjm 1231 15 ethanol ethanol NN cord-023095-4dannjjm 1231 16 , , , cord-023095-4dannjjm 1231 17 and and CC cord-023095-4dannjjm 1231 18 paraffin paraffin NN cord-023095-4dannjjm 1231 19 - - HYPH cord-023095-4dannjjm 1231 20 embedded embed VBN cord-023095-4dannjjm 1231 21 . . . cord-023095-4dannjjm 1232 1 Laminar laminar JJ cord-023095-4dannjjm 1232 2 sections section NNS cord-023095-4dannjjm 1232 3 were be VBD cord-023095-4dannjjm 1232 4 stained stain VBN cord-023095-4dannjjm 1232 5 immunohistochemically immunohistochemically RB cord-023095-4dannjjm 1232 6 for for IN cord-023095-4dannjjm 1232 7 IRc irc NN cord-023095-4dannjjm 1232 8 using use VBG cord-023095-4dannjjm 1232 9 a a DT cord-023095-4dannjjm 1232 10 commercially commercially RB cord-023095-4dannjjm 1232 11 - - HYPH cord-023095-4dannjjm 1232 12 available available JJ cord-023095-4dannjjm 1232 13 antibody antibody NN cord-023095-4dannjjm 1232 14 ( ( -LRB- cord-023095-4dannjjm 1232 15 Abcam Abcam NNP cord-023095-4dannjjm 1232 16 ) ) -RRB- cord-023095-4dannjjm 1232 17 ; ; : cord-023095-4dannjjm 1232 18 the the DT cord-023095-4dannjjm 1232 19 number number NN cord-023095-4dannjjm 1232 20 of of IN cord-023095-4dannjjm 1232 21 IRc irc NN cord-023095-4dannjjm 1232 22 ( ( -LRB- cord-023095-4dannjjm 1232 23 1 1 CD cord-023095-4dannjjm 1232 24 ) ) -RRB- cord-023095-4dannjjm 1232 25 cells cell NNS cord-023095-4dannjjm 1232 26 was be VBD cord-023095-4dannjjm 1232 27 quantified quantify VBN cord-023095-4dannjjm 1232 28 in in IN cord-023095-4dannjjm 1232 29 40x 40x CD cord-023095-4dannjjm 1232 30 light light JJ cord-023095-4dannjjm 1232 31 microscopy microscopy NN cord-023095-4dannjjm 1232 32 fields field NNS cord-023095-4dannjjm 1232 33 ( ( -LRB- cord-023095-4dannjjm 1232 34 n n NN cord-023095-4dannjjm 1232 35 5 5 CD cord-023095-4dannjjm 1232 36 10 10 CD cord-023095-4dannjjm 1232 37 ) ) -RRB- cord-023095-4dannjjm 1232 38 for for IN cord-023095-4dannjjm 1232 39 each each DT cord-023095-4dannjjm 1232 40 section section NN cord-023095-4dannjjm 1232 41 . . . cord-023095-4dannjjm 1233 1 The the DT cord-023095-4dannjjm 1233 2 total total JJ cord-023095-4dannjjm 1233 3 number number NN cord-023095-4dannjjm 1233 4 of of IN cord-023095-4dannjjm 1233 5 IRc irc NN cord-023095-4dannjjm 1233 6 ( ( -LRB- cord-023095-4dannjjm 1233 7 1 1 CD cord-023095-4dannjjm 1233 8 ) ) -RRB- cord-023095-4dannjjm 1233 9 cells cell NNS cord-023095-4dannjjm 1233 10 was be VBD cord-023095-4dannjjm 1233 11 greater great JJR cord-023095-4dannjjm 1233 12 in in IN cord-023095-4dannjjm 1233 13 the the DT cord-023095-4dannjjm 1233 14 laminae laminae NN cord-023095-4dannjjm 1233 15 of of IN cord-023095-4dannjjm 1233 16 challenged challenge VBN cord-023095-4dannjjm 1233 17 ponies pony NNS cord-023095-4dannjjm 1233 18 than than IN cord-023095-4dannjjm 1233 19 control control NN cord-023095-4dannjjm 1233 20 ponies pony NNS cord-023095-4dannjjm 1233 21 ( ( -LRB- cord-023095-4dannjjm 1233 22 p p NN cord-023095-4dannjjm 1233 23 5 5 CD cord-023095-4dannjjm 1233 24 0.0096 0.0096 CD cord-023095-4dannjjm 1233 25 ) ) -RRB- cord-023095-4dannjjm 1233 26 , , , cord-023095-4dannjjm 1233 27 and and CC cord-023095-4dannjjm 1233 28 there there EX cord-023095-4dannjjm 1233 29 was be VBD cord-023095-4dannjjm 1233 30 a a DT cord-023095-4dannjjm 1233 31 significant significant JJ cord-023095-4dannjjm 1233 32 correlation correlation NN cord-023095-4dannjjm 1233 33 between between IN cord-023095-4dannjjm 1233 34 the the DT cord-023095-4dannjjm 1233 35 change change NN cord-023095-4dannjjm 1233 36 in in IN cord-023095-4dannjjm 1233 37 serum serum NN cord-023095-4dannjjm 1233 38 basal basal NN cord-023095-4dannjjm 1233 39 insulin insulin NN cord-023095-4dannjjm 1233 40 concentration concentration NN cord-023095-4dannjjm 1233 41 and and CC cord-023095-4dannjjm 1233 42 number number NN cord-023095-4dannjjm 1233 43 of of IN cord-023095-4dannjjm 1233 44 laminar laminar JJ cord-023095-4dannjjm 1233 45 IRc irc NN cord-023095-4dannjjm 1233 46 ( ( -LRB- cord-023095-4dannjjm 1233 47 1 1 CD cord-023095-4dannjjm 1233 48 ) ) -RRB- cord-023095-4dannjjm 1233 49 endothelial endothelial JJ cord-023095-4dannjjm 1233 50 cells cell NNS cord-023095-4dannjjm 1233 51 ( ( -LRB- cord-023095-4dannjjm 1233 52 r r NN cord-023095-4dannjjm 1233 53 5 5 CD cord-023095-4dannjjm 1233 54 0.74 0.74 CD cord-023095-4dannjjm 1233 55 ; ; : cord-023095-4dannjjm 1233 56 p p NN cord-023095-4dannjjm 1233 57 o o NN cord-023095-4dannjjm 1233 58 0.05 0.05 CD cord-023095-4dannjjm 1233 59 ) ) -RRB- cord-023095-4dannjjm 1233 60 . . . cord-023095-4dannjjm 1234 1 While while IN cord-023095-4dannjjm 1234 2 the the DT cord-023095-4dannjjm 1234 3 number number NN cord-023095-4dannjjm 1234 4 of of IN cord-023095-4dannjjm 1234 5 IRc irc NN cord-023095-4dannjjm 1234 6 ( ( -LRB- cord-023095-4dannjjm 1234 7 1 1 CD cord-023095-4dannjjm 1234 8 ) ) -RRB- cord-023095-4dannjjm 1234 9 endothelial endothelial JJ cord-023095-4dannjjm 1234 10 cells cell NNS cord-023095-4dannjjm 1234 11 was be VBD cord-023095-4dannjjm 1234 12 significantly significantly RB cord-023095-4dannjjm 1234 13 greater great JJR cord-023095-4dannjjm 1234 14 in in IN cord-023095-4dannjjm 1234 15 the the DT cord-023095-4dannjjm 1234 16 dermal dermal JJ cord-023095-4dannjjm 1234 17 laminae laminae NN cord-023095-4dannjjm 1234 18 of of IN cord-023095-4dannjjm 1234 19 challenged challenge VBN cord-023095-4dannjjm 1234 20 ponies pony NNS cord-023095-4dannjjm 1234 21 ( ( -LRB- cord-023095-4dannjjm 1234 22 p p NN cord-023095-4dannjjm 1234 23 5 5 CD cord-023095-4dannjjm 1234 24 0.0095 0.0095 CD cord-023095-4dannjjm 1234 25 ) ) -RRB- cord-023095-4dannjjm 1234 26 , , , cord-023095-4dannjjm 1234 27 there there EX cord-023095-4dannjjm 1234 28 was be VBD cord-023095-4dannjjm 1234 29 no no DT cord-023095-4dannjjm 1234 30 difference difference NN cord-023095-4dannjjm 1234 31 in in IN cord-023095-4dannjjm 1234 32 the the DT cord-023095-4dannjjm 1234 33 number number NN cord-023095-4dannjjm 1234 34 of of IN cord-023095-4dannjjm 1234 35 interstitial interstitial JJ cord-023095-4dannjjm 1234 36 IRc irc NN cord-023095-4dannjjm 1234 37 ( ( -LRB- cord-023095-4dannjjm 1234 38 1 1 CD cord-023095-4dannjjm 1234 39 ) ) -RRB- cord-023095-4dannjjm 1234 40 cells cell NNS cord-023095-4dannjjm 1234 41 ( ( -LRB- cord-023095-4dannjjm 1234 42 p p NN cord-023095-4dannjjm 1234 43 5 5 CD cord-023095-4dannjjm 1234 44 0.82 0.82 CD cord-023095-4dannjjm 1234 45 ) ) -RRB- cord-023095-4dannjjm 1234 46 . . . cord-023095-4dannjjm 1235 1 No no DT cord-023095-4dannjjm 1235 2 epithelial epithelial JJ cord-023095-4dannjjm 1235 3 IRc irc NN cord-023095-4dannjjm 1235 4 ( ( -LRB- cord-023095-4dannjjm 1235 5 1 1 CD cord-023095-4dannjjm 1235 6 ) ) -RRB- cord-023095-4dannjjm 1235 7 cells cell NNS cord-023095-4dannjjm 1235 8 were be VBD cord-023095-4dannjjm 1235 9 observed observe VBN cord-023095-4dannjjm 1235 10 in in IN cord-023095-4dannjjm 1235 11 any any DT cord-023095-4dannjjm 1235 12 laminar laminar JJ cord-023095-4dannjjm 1235 13 section section NN cord-023095-4dannjjm 1235 14 , , , cord-023095-4dannjjm 1235 15 and and CC cord-023095-4dannjjm 1235 16 IRc irc NN cord-023095-4dannjjm 1235 17 ( ( -LRB- cord-023095-4dannjjm 1235 18 1 1 CD cord-023095-4dannjjm 1235 19 ) ) -RRB- cord-023095-4dannjjm 1235 20 cells cell NNS cord-023095-4dannjjm 1235 21 were be VBD cord-023095-4dannjjm 1235 22 conspicuously conspicuously RB cord-023095-4dannjjm 1235 23 absent absent JJ cord-023095-4dannjjm 1235 24 from from IN cord-023095-4dannjjm 1235 25 the the DT cord-023095-4dannjjm 1235 26 deep deep JJ cord-023095-4dannjjm 1235 27 dermal dermal JJ cord-023095-4dannjjm 1235 28 tissue tissue NN cord-023095-4dannjjm 1235 29 ( ( -LRB- cord-023095-4dannjjm 1235 30 including include VBG cord-023095-4dannjjm 1235 31 vessels vessel NNS cord-023095-4dannjjm 1235 32 ) ) -RRB- cord-023095-4dannjjm 1235 33 . . . cord-023095-4dannjjm 1236 1 Up up IN cord-023095-4dannjjm 1236 2 - - HYPH cord-023095-4dannjjm 1236 3 regulation regulation NN cord-023095-4dannjjm 1236 4 of of IN cord-023095-4dannjjm 1236 5 IRc irc JJ cord-023095-4dannjjm 1236 6 expression expression NN cord-023095-4dannjjm 1236 7 in in IN cord-023095-4dannjjm 1236 8 the the DT cord-023095-4dannjjm 1236 9 laminar laminar JJ cord-023095-4dannjjm 1236 10 vasculature vasculature NN cord-023095-4dannjjm 1236 11 occurs occur VBZ cord-023095-4dannjjm 1236 12 acutely acutely RB cord-023095-4dannjjm 1236 13 in in IN cord-023095-4dannjjm 1236 14 response response NN cord-023095-4dannjjm 1236 15 to to IN cord-023095-4dannjjm 1236 16 dietary dietary JJ cord-023095-4dannjjm 1236 17 carbohydrate carbohydrate NN cord-023095-4dannjjm 1236 18 challenge challenge NN cord-023095-4dannjjm 1236 19 and and CC cord-023095-4dannjjm 1236 20 accompanies accompany VBZ cord-023095-4dannjjm 1236 21 hyperinsulinemia hyperinsulinemia NN cord-023095-4dannjjm 1236 22 in in IN cord-023095-4dannjjm 1236 23 ponies pony NNS cord-023095-4dannjjm 1236 24 . . . cord-023095-4dannjjm 1237 1 The the DT cord-023095-4dannjjm 1237 2 dramatic dramatic JJ cord-023095-4dannjjm 1237 3 increase increase NN cord-023095-4dannjjm 1237 4 in in IN cord-023095-4dannjjm 1237 5 endothelial endothelial JJ cord-023095-4dannjjm 1237 6 IRc irc JJ cord-023095-4dannjjm 1237 7 expression expression NN cord-023095-4dannjjm 1237 8 in in IN cord-023095-4dannjjm 1237 9 the the DT cord-023095-4dannjjm 1237 10 laminar laminar JJ cord-023095-4dannjjm 1237 11 microvasculature microvasculature NN cord-023095-4dannjjm 1237 12 in in IN cord-023095-4dannjjm 1237 13 nutritionally nutritionally RB cord-023095-4dannjjm 1237 14 challenged challenge VBN cord-023095-4dannjjm 1237 15 ponies pony NNS cord-023095-4dannjjm 1237 16 , , , cord-023095-4dannjjm 1237 17 with with IN cord-023095-4dannjjm 1237 18 no no DT cord-023095-4dannjjm 1237 19 apparent apparent JJ cord-023095-4dannjjm 1237 20 epithelial epithelial JJ cord-023095-4dannjjm 1237 21 IRc irc NN cord-023095-4dannjjm 1237 22 present present NN cord-023095-4dannjjm 1237 23 , , , cord-023095-4dannjjm 1237 24 suggests suggest VBZ cord-023095-4dannjjm 1237 25 that that IN cord-023095-4dannjjm 1237 26 hyperinsulinemia hyperinsulinemia NN cord-023095-4dannjjm 1237 27 associated associate VBN cord-023095-4dannjjm 1237 28 with with IN cord-023095-4dannjjm 1237 29 exposure exposure NN cord-023095-4dannjjm 1237 30 to to IN cord-023095-4dannjjm 1237 31 increased increase VBN cord-023095-4dannjjm 1237 32 dietary dietary JJ cord-023095-4dannjjm 1237 33 NSC NSC NNP cord-023095-4dannjjm 1237 34 may may MD cord-023095-4dannjjm 1237 35 induce induce VB cord-023095-4dannjjm 1237 36 laminar laminar JJ cord-023095-4dannjjm 1237 37 injury injury NN cord-023095-4dannjjm 1237 38 by by IN cord-023095-4dannjjm 1237 39 causing cause VBG cord-023095-4dannjjm 1237 40 a a DT cord-023095-4dannjjm 1237 41 similar similar JJ cord-023095-4dannjjm 1237 42 vasoconstriction vasoconstriction NN cord-023095-4dannjjm 1237 43 in in IN cord-023095-4dannjjm 1237 44 IR IR NNP cord-023095-4dannjjm 1237 45 equids equid NNS cord-023095-4dannjjm 1237 46 as as IN cord-023095-4dannjjm 1237 47 described describe VBN cord-023095-4dannjjm 1237 48 in in IN cord-023095-4dannjjm 1237 49 the the DT cord-023095-4dannjjm 1237 50 microvasculature microvasculature NN cord-023095-4dannjjm 1237 51 of of IN cord-023095-4dannjjm 1237 52 IR IR NNP cord-023095-4dannjjm 1237 53 humans human NNS cord-023095-4dannjjm 1237 54 . . . cord-023095-4dannjjm 1238 1 Glucose glucose NN cord-023095-4dannjjm 1238 2 transport transport NN cord-023095-4dannjjm 1238 3 from from IN cord-023095-4dannjjm 1238 4 the the DT cord-023095-4dannjjm 1238 5 blood blood NN cord-023095-4dannjjm 1238 6 stream stream NN cord-023095-4dannjjm 1238 7 into into IN cord-023095-4dannjjm 1238 8 cells cell NNS cord-023095-4dannjjm 1238 9 , , , cord-023095-4dannjjm 1238 10 the the DT cord-023095-4dannjjm 1238 11 limiting limit VBG cord-023095-4dannjjm 1238 12 step step NN cord-023095-4dannjjm 1238 13 in in IN cord-023095-4dannjjm 1238 14 whole whole JJ cord-023095-4dannjjm 1238 15 - - HYPH cord-023095-4dannjjm 1238 16 body body NN cord-023095-4dannjjm 1238 17 glucose glucose NN cord-023095-4dannjjm 1238 18 utilization utilization NN cord-023095-4dannjjm 1238 19 , , , cord-023095-4dannjjm 1238 20 is be VBZ cord-023095-4dannjjm 1238 21 regulated regulate VBN cord-023095-4dannjjm 1238 22 by by IN cord-023095-4dannjjm 1238 23 a a DT cord-023095-4dannjjm 1238 24 family family NN cord-023095-4dannjjm 1238 25 of of IN cord-023095-4dannjjm 1238 26 glucose glucose NN cord-023095-4dannjjm 1238 27 transporter transporter NN cord-023095-4dannjjm 1238 28 ( ( -LRB- cord-023095-4dannjjm 1238 29 GLUT glut NN cord-023095-4dannjjm 1238 30 ) ) -RRB- cord-023095-4dannjjm 1238 31 proteins protein NNS cord-023095-4dannjjm 1238 32 in in IN cord-023095-4dannjjm 1238 33 insulin insulin NN cord-023095-4dannjjm 1238 34 - - HYPH cord-023095-4dannjjm 1238 35 sensitive sensitive JJ cord-023095-4dannjjm 1238 36 ( ( -LRB- cord-023095-4dannjjm 1238 37 i.e. i.e. FW cord-023095-4dannjjm 1238 38 , , , cord-023095-4dannjjm 1238 39 muscle muscle NN cord-023095-4dannjjm 1238 40 and and CC cord-023095-4dannjjm 1238 41 adipose adipose NN cord-023095-4dannjjm 1238 42 ) ) -RRB- cord-023095-4dannjjm 1238 43 tissues tissue NNS cord-023095-4dannjjm 1238 44 . . . cord-023095-4dannjjm 1239 1 We -PRON- PRP cord-023095-4dannjjm 1239 2 previously previously RB cord-023095-4dannjjm 1239 3 demonstrated demonstrate VBD cord-023095-4dannjjm 1239 4 that that IN cord-023095-4dannjjm 1239 5 GLUT4 GLUT4 NNP cord-023095-4dannjjm 1239 6 , , , cord-023095-4dannjjm 1239 7 the the DT cord-023095-4dannjjm 1239 8 major major JJ cord-023095-4dannjjm 1239 9 isoform isoform NN cord-023095-4dannjjm 1239 10 , , , cord-023095-4dannjjm 1239 11 is be VBZ cord-023095-4dannjjm 1239 12 a a DT cord-023095-4dannjjm 1239 13 key key JJ cord-023095-4dannjjm 1239 14 factor factor NN cord-023095-4dannjjm 1239 15 in in IN cord-023095-4dannjjm 1239 16 the the DT cord-023095-4dannjjm 1239 17 pathogenesis pathogenesis NN cord-023095-4dannjjm 1239 18 of of IN cord-023095-4dannjjm 1239 19 equine equine JJ cord-023095-4dannjjm 1239 20 insulin insulin NN cord-023095-4dannjjm 1239 21 resistance resistance NN cord-023095-4dannjjm 1239 22 ( ( -LRB- cord-023095-4dannjjm 1239 23 IR IR NNP cord-023095-4dannjjm 1239 24 ) ) -RRB- cord-023095-4dannjjm 1239 25 . . . cord-023095-4dannjjm 1240 1 While while IN cord-023095-4dannjjm 1240 2 it -PRON- PRP cord-023095-4dannjjm 1240 3 has have VBZ cord-023095-4dannjjm 1240 4 been be VBN cord-023095-4dannjjm 1240 5 recently recently RB cord-023095-4dannjjm 1240 6 demonstrated demonstrate VBN cord-023095-4dannjjm 1240 7 that that IN cord-023095-4dannjjm 1240 8 GLUT12 GLUT12 NNP cord-023095-4dannjjm 1240 9 ( ( -LRB- cord-023095-4dannjjm 1240 10 a a DT cord-023095-4dannjjm 1240 11 newly newly RB cord-023095-4dannjjm 1240 12 discovered discover VBN cord-023095-4dannjjm 1240 13 isoform isoform NN cord-023095-4dannjjm 1240 14 ) ) -RRB- cord-023095-4dannjjm 1240 15 increases increase VBZ cord-023095-4dannjjm 1240 16 insulin insulin NN cord-023095-4dannjjm 1240 17 - - HYPH cord-023095-4dannjjm 1240 18 stimulated stimulate VBN cord-023095-4dannjjm 1240 19 glucose glucose NN cord-023095-4dannjjm 1240 20 transport transport NN cord-023095-4dannjjm 1240 21 in in IN cord-023095-4dannjjm 1240 22 human human JJ cord-023095-4dannjjm 1240 23 muscle muscle NN cord-023095-4dannjjm 1240 24 , , , cord-023095-4dannjjm 1240 25 its -PRON- PRP$ cord-023095-4dannjjm 1240 26 role role NN cord-023095-4dannjjm 1240 27 in in IN cord-023095-4dannjjm 1240 28 other other JJ cord-023095-4dannjjm 1240 29 tissues tissue NNS cord-023095-4dannjjm 1240 30 , , , cord-023095-4dannjjm 1240 31 particularly particularly RB cord-023095-4dannjjm 1240 32 in in IN cord-023095-4dannjjm 1240 33 the the DT cord-023095-4dannjjm 1240 34 setting setting NN cord-023095-4dannjjm 1240 35 of of IN cord-023095-4dannjjm 1240 36 IR IR NNP cord-023095-4dannjjm 1240 37 , , , cord-023095-4dannjjm 1240 38 is be VBZ cord-023095-4dannjjm 1240 39 not not RB cord-023095-4dannjjm 1240 40 well well RB cord-023095-4dannjjm 1240 41 characterized characterize VBN cord-023095-4dannjjm 1240 42 in in IN cord-023095-4dannjjm 1240 43 any any DT cord-023095-4dannjjm 1240 44 species specie NNS cord-023095-4dannjjm 1240 45 . . . cord-023095-4dannjjm 1241 1 In in IN cord-023095-4dannjjm 1241 2 addition addition NN cord-023095-4dannjjm 1241 3 , , , cord-023095-4dannjjm 1241 4 AS160 AS160 NNP cord-023095-4dannjjm 1241 5 has have VBZ cord-023095-4dannjjm 1241 6 recently recently RB cord-023095-4dannjjm 1241 7 emerged emerge VBN cord-023095-4dannjjm 1241 8 as as IN cord-023095-4dannjjm 1241 9 a a DT cord-023095-4dannjjm 1241 10 key key JJ cord-023095-4dannjjm 1241 11 downstream downstream NN cord-023095-4dannjjm 1241 12 signaling signaling NN cord-023095-4dannjjm 1241 13 molecule molecule NN cord-023095-4dannjjm 1241 14 regulating regulate VBG cord-023095-4dannjjm 1241 15 translocation translocation NN cord-023095-4dannjjm 1241 16 of of IN cord-023095-4dannjjm 1241 17 GLUT glut NN cord-023095-4dannjjm 1241 18 to to IN cord-023095-4dannjjm 1241 19 the the DT cord-023095-4dannjjm 1241 20 cell cell NN cord-023095-4dannjjm 1241 21 surface surface NN cord-023095-4dannjjm 1241 22 , , , cord-023095-4dannjjm 1241 23 the the DT cord-023095-4dannjjm 1241 24 rate rate NN cord-023095-4dannjjm 1241 25 - - HYPH cord-023095-4dannjjm 1241 26 limiting limit VBG cord-023095-4dannjjm 1241 27 step step NN cord-023095-4dannjjm 1241 28 in in IN cord-023095-4dannjjm 1241 29 glucose glucose NN cord-023095-4dannjjm 1241 30 uptake uptake NN cord-023095-4dannjjm 1241 31 . . . cord-023095-4dannjjm 1242 1 We -PRON- PRP cord-023095-4dannjjm 1242 2 hypothesized hypothesize VBD cord-023095-4dannjjm 1242 3 that that IN cord-023095-4dannjjm 1242 4 GLUT12 GLUT12 NNP cord-023095-4dannjjm 1242 5 content content NN cord-023095-4dannjjm 1242 6 would would MD cord-023095-4dannjjm 1242 7 be be VB cord-023095-4dannjjm 1242 8 differentially differentially RB cord-023095-4dannjjm 1242 9 expressed express VBN cord-023095-4dannjjm 1242 10 across across IN cord-023095-4dannjjm 1242 11 tissues tissue NNS cord-023095-4dannjjm 1242 12 and and CC cord-023095-4dannjjm 1242 13 that that IN cord-023095-4dannjjm 1242 14 IR IR NNP cord-023095-4dannjjm 1242 15 would would MD cord-023095-4dannjjm 1242 16 induce induce VB cord-023095-4dannjjm 1242 17 alteration alteration NN cord-023095-4dannjjm 1242 18 in in IN cord-023095-4dannjjm 1242 19 glucose glucose NN cord-023095-4dannjjm 1242 20 transport transport NN cord-023095-4dannjjm 1242 21 by by IN cord-023095-4dannjjm 1242 22 affecting affect VBG cord-023095-4dannjjm 1242 23 active active JJ cord-023095-4dannjjm 1242 24 cell cell NN cord-023095-4dannjjm 1242 25 surface surface NN cord-023095-4dannjjm 1243 1 GLUT12 glut12 RB cord-023095-4dannjjm 1243 2 . . . cord-023095-4dannjjm 1244 1 Biopsies biopsy NNS cord-023095-4dannjjm 1244 2 of of IN cord-023095-4dannjjm 1244 3 skeletal skeletal JJ cord-023095-4dannjjm 1244 4 muscle muscle NN cord-023095-4dannjjm 1244 5 , , , cord-023095-4dannjjm 1244 6 and and CC cord-023095-4dannjjm 1244 7 subcutaneous subcutaneous JJ cord-023095-4dannjjm 1244 8 and and CC cord-023095-4dannjjm 1244 9 visceral visceral JJ cord-023095-4dannjjm 1244 10 adipose adipose JJ cord-023095-4dannjjm 1244 11 tissue tissue NN cord-023095-4dannjjm 1244 12 were be VBD cord-023095-4dannjjm 1244 13 collected collect VBN cord-023095-4dannjjm 1244 14 from from IN cord-023095-4dannjjm 1244 15 light light JJ cord-023095-4dannjjm 1244 16 - - HYPH cord-023095-4dannjjm 1244 17 breed breed NN cord-023095-4dannjjm 1244 18 horses horse NNS cord-023095-4dannjjm 1244 19 , , , cord-023095-4dannjjm 1244 20 characterized characterize VBN cord-023095-4dannjjm 1244 21 as as IN cord-023095-4dannjjm 1244 22 either either DT cord-023095-4dannjjm 1244 23 insulin insulin NN cord-023095-4dannjjm 1244 24 sensitive sensitive JJ cord-023095-4dannjjm 1244 25 or or CC cord-023095-4dannjjm 1244 26 compensated compensate VBN cord-023095-4dannjjm 1244 27 IR IR NNP cord-023095-4dannjjm 1244 28 , , , cord-023095-4dannjjm 1244 29 based base VBN cord-023095-4dannjjm 1244 30 on on IN cord-023095-4dannjjm 1244 31 the the DT cord-023095-4dannjjm 1244 32 results result NNS cord-023095-4dannjjm 1244 33 of of IN cord-023095-4dannjjm 1244 34 an an DT cord-023095-4dannjjm 1244 35 insulin insulin NN cord-023095-4dannjjm 1244 36 - - HYPH cord-023095-4dannjjm 1244 37 modified modify VBN cord-023095-4dannjjm 1244 38 frequently frequently RB cord-023095-4dannjjm 1244 39 - - HYPH cord-023095-4dannjjm 1244 40 sampled sample VBN cord-023095-4dannjjm 1244 41 intravenous intravenous JJ cord-023095-4dannjjm 1244 42 glucose glucose NN cord-023095-4dannjjm 1244 43 tolerance tolerance NN cord-023095-4dannjjm 1244 44 test test NN cord-023095-4dannjjm 1244 45 ( ( -LRB- cord-023095-4dannjjm 1244 46 n n NN cord-023095-4dannjjm 1244 47 5 5 CD cord-023095-4dannjjm 1244 48 5 5 CD cord-023095-4dannjjm 1244 49 / / SYM cord-023095-4dannjjm 1244 50 group group NN cord-023095-4dannjjm 1244 51 ) ) -RRB- cord-023095-4dannjjm 1244 52 . . . cord-023095-4dannjjm 1245 1 We -PRON- PRP cord-023095-4dannjjm 1245 2 specifically specifically RB cord-023095-4dannjjm 1245 3 quantified quantify VBD cord-023095-4dannjjm 1245 4 active active JJ cord-023095-4dannjjm 1245 5 cell cell NN cord-023095-4dannjjm 1245 6 - - HYPH cord-023095-4dannjjm 1245 7 surface surface NN cord-023095-4dannjjm 1245 8 GLUT12 glut12 RB cord-023095-4dannjjm 1245 9 in in IN cord-023095-4dannjjm 1245 10 these these DT cord-023095-4dannjjm 1245 11 biopsies biopsy NNS cord-023095-4dannjjm 1245 12 , , , cord-023095-4dannjjm 1245 13 using use VBG cord-023095-4dannjjm 1245 14 an an DT cord-023095-4dannjjm 1245 15 innovative innovative JJ cord-023095-4dannjjm 1245 16 exofacial exofacial JJ cord-023095-4dannjjm 1245 17 bismannose bismannose NN cord-023095-4dannjjm 1245 18 photolabeled photolabeled JJ cord-023095-4dannjjm 1245 19 assay assay NN cord-023095-4dannjjm 1245 20 , , , cord-023095-4dannjjm 1245 21 which which WDT cord-023095-4dannjjm 1245 22 has have VBZ cord-023095-4dannjjm 1245 23 not not RB cord-023095-4dannjjm 1245 24 been be VBN cord-023095-4dannjjm 1245 25 previously previously RB cord-023095-4dannjjm 1245 26 applied apply VBN cord-023095-4dannjjm 1245 27 to to IN cord-023095-4dannjjm 1245 28 GLUT12 GLUT12 NNP cord-023095-4dannjjm 1245 29 . . . cord-023095-4dannjjm 1246 1 Total total JJ cord-023095-4dannjjm 1247 1 GLUT12 glut12 RB cord-023095-4dannjjm 1247 2 protein protein NN cord-023095-4dannjjm 1247 3 expression expression NN cord-023095-4dannjjm 1247 4 was be VBD cord-023095-4dannjjm 1247 5 measured measure VBN cord-023095-4dannjjm 1247 6 by by IN cord-023095-4dannjjm 1247 7 Western western JJ cord-023095-4dannjjm 1247 8 blots blot NNS cord-023095-4dannjjm 1247 9 , , , cord-023095-4dannjjm 1247 10 as as RB cord-023095-4dannjjm 1247 11 well well RB cord-023095-4dannjjm 1247 12 as as IN cord-023095-4dannjjm 1247 13 total total JJ cord-023095-4dannjjm 1247 14 and and CC cord-023095-4dannjjm 1247 15 phosphorylated phosphorylated JJ cord-023095-4dannjjm 1247 16 ( ( -LRB- cord-023095-4dannjjm 1247 17 indicating indicate VBG cord-023095-4dannjjm 1247 18 activation activation NN cord-023095-4dannjjm 1247 19 of of IN cord-023095-4dannjjm 1247 20 ) ) -RRB- cord-023095-4dannjjm 1248 1 AS160 AS160 NNP cord-023095-4dannjjm 1248 2 . . . cord-023095-4dannjjm 1249 1 GLUT12 GLUT12 NNP cord-023095-4dannjjm 1249 2 was be VBD cord-023095-4dannjjm 1249 3 expressed express VBN cord-023095-4dannjjm 1249 4 in in IN cord-023095-4dannjjm 1249 5 all all PDT cord-023095-4dannjjm 1249 6 the the DT cord-023095-4dannjjm 1249 7 depots depot NNS cord-023095-4dannjjm 1249 8 with with IN cord-023095-4dannjjm 1249 9 a a DT cord-023095-4dannjjm 1249 10 significant significant JJ cord-023095-4dannjjm 1249 11 regional regional JJ cord-023095-4dannjjm 1249 12 effect effect NN cord-023095-4dannjjm 1249 13 . . . cord-023095-4dannjjm 1250 1 Total total JJ cord-023095-4dannjjm 1250 2 GLUT12 GLUT12 NNP cord-023095-4dannjjm 1250 3 protein protein NN cord-023095-4dannjjm 1250 4 content content NN cord-023095-4dannjjm 1250 5 was be VBD cord-023095-4dannjjm 1250 6 increased increase VBN cord-023095-4dannjjm 1250 7 ( ( -LRB- cord-023095-4dannjjm 1250 8 P p NN cord-023095-4dannjjm 1250 9 o o NN cord-023095-4dannjjm 1250 10 0.05 0.05 CD cord-023095-4dannjjm 1250 11 ) ) -RRB- cord-023095-4dannjjm 1250 12 in in IN cord-023095-4dannjjm 1250 13 visceral visceral JJ cord-023095-4dannjjm 1250 14 ( ( -LRB- cord-023095-4dannjjm 1250 15 omental omental JJ cord-023095-4dannjjm 1250 16 and and CC cord-023095-4dannjjm 1250 17 mesenteric mesenteric JJ cord-023095-4dannjjm 1250 18 ) ) -RRB- cord-023095-4dannjjm 1250 19 compared compare VBN cord-023095-4dannjjm 1250 20 to to IN cord-023095-4dannjjm 1250 21 subcutaneous subcutaneous JJ cord-023095-4dannjjm 1250 22 ( ( -LRB- cord-023095-4dannjjm 1250 23 nuchal nuchal JJ cord-023095-4dannjjm 1250 24 ligament ligament NN cord-023095-4dannjjm 1250 25 and and CC cord-023095-4dannjjm 1250 26 tailhead tailhead NN cord-023095-4dannjjm 1250 27 ) ) -RRB- cord-023095-4dannjjm 1250 28 adipose adipose JJ cord-023095-4dannjjm 1250 29 tissue tissue NN cord-023095-4dannjjm 1250 30 and and CC cord-023095-4dannjjm 1250 31 skeletal skeletal JJ cord-023095-4dannjjm 1250 32 muscle muscle NN cord-023095-4dannjjm 1250 33 of of IN cord-023095-4dannjjm 1250 34 healthy healthy JJ cord-023095-4dannjjm 1250 35 horses horse NNS cord-023095-4dannjjm 1250 36 . . . cord-023095-4dannjjm 1251 1 IR IR NNP cord-023095-4dannjjm 1251 2 did do VBD cord-023095-4dannjjm 1251 3 not not RB cord-023095-4dannjjm 1251 4 induce induce VB cord-023095-4dannjjm 1251 5 alterations alteration NNS cord-023095-4dannjjm 1251 6 in in IN cord-023095-4dannjjm 1251 7 active active JJ cord-023095-4dannjjm 1251 8 cell cell NN cord-023095-4dannjjm 1251 9 - - HYPH cord-023095-4dannjjm 1251 10 surface surface NN cord-023095-4dannjjm 1251 11 and and CC cord-023095-4dannjjm 1251 12 total total NN cord-023095-4dannjjm 1251 13 GLUT12 GLUT12 NNP cord-023095-4dannjjm 1251 14 content content NN cord-023095-4dannjjm 1251 15 nor nor CC cord-023095-4dannjjm 1251 16 in in IN cord-023095-4dannjjm 1251 17 total total JJ cord-023095-4dannjjm 1251 18 and and CC cord-023095-4dannjjm 1251 19 phosphorylated phosphorylated JJ cord-023095-4dannjjm 1251 20 AS160 as160 NN cord-023095-4dannjjm 1251 21 in in IN cord-023095-4dannjjm 1251 22 any any DT cord-023095-4dannjjm 1251 23 of of IN cord-023095-4dannjjm 1251 24 the the DT cord-023095-4dannjjm 1251 25 tissues tissue NNS cord-023095-4dannjjm 1251 26 evaluated evaluate VBN cord-023095-4dannjjm 1251 27 . . . cord-023095-4dannjjm 1252 1 Our -PRON- PRP$ cord-023095-4dannjjm 1252 2 data data NN cord-023095-4dannjjm 1252 3 suggests suggest VBZ cord-023095-4dannjjm 1252 4 that that IN cord-023095-4dannjjm 1252 5 GLUT12 GLUT12 NNP cord-023095-4dannjjm 1252 6 is be VBZ cord-023095-4dannjjm 1252 7 abundant abundant JJ cord-023095-4dannjjm 1252 8 in in IN cord-023095-4dannjjm 1252 9 visceral visceral JJ cord-023095-4dannjjm 1252 10 adipose adipose JJ cord-023095-4dannjjm 1252 11 tissue tissue NN cord-023095-4dannjjm 1252 12 and and CC cord-023095-4dannjjm 1252 13 is be VBZ cord-023095-4dannjjm 1252 14 therefore therefore RB cord-023095-4dannjjm 1252 15 likely likely JJ cord-023095-4dannjjm 1252 16 to to TO cord-023095-4dannjjm 1252 17 play play VB cord-023095-4dannjjm 1252 18 a a DT cord-023095-4dannjjm 1252 19 substantial substantial JJ cord-023095-4dannjjm 1252 20 role role NN cord-023095-4dannjjm 1252 21 in in IN cord-023095-4dannjjm 1252 22 the the DT cord-023095-4dannjjm 1252 23 regulation regulation NN cord-023095-4dannjjm 1252 24 of of IN cord-023095-4dannjjm 1252 25 glucose glucose NN cord-023095-4dannjjm 1252 26 transport transport NN cord-023095-4dannjjm 1252 27 . . . cord-023095-4dannjjm 1253 1 However however RB cord-023095-4dannjjm 1253 2 , , , cord-023095-4dannjjm 1253 3 neither neither CC cord-023095-4dannjjm 1253 4 GLUT12 GLUT12 NNP cord-023095-4dannjjm 1253 5 translocation translocation NN cord-023095-4dannjjm 1253 6 nor nor CC cord-023095-4dannjjm 1253 7 AS160 as160 CD cord-023095-4dannjjm 1253 8 activation activation NN cord-023095-4dannjjm 1253 9 are be VBP cord-023095-4dannjjm 1253 10 impaired impair VBN cord-023095-4dannjjm 1253 11 in in IN cord-023095-4dannjjm 1253 12 insulin insulin NN cord-023095-4dannjjm 1253 13 - - HYPH cord-023095-4dannjjm 1253 14 sensitive sensitive JJ cord-023095-4dannjjm 1253 15 tissues tissue NNS cord-023095-4dannjjm 1253 16 of of IN cord-023095-4dannjjm 1253 17 IR IR NNP cord-023095-4dannjjm 1253 18 horses horse NNS cord-023095-4dannjjm 1253 19 . . . cord-023095-4dannjjm 1254 1 It -PRON- PRP cord-023095-4dannjjm 1254 2 is be VBZ cord-023095-4dannjjm 1254 3 concluded conclude VBN cord-023095-4dannjjm 1254 4 that that IN cord-023095-4dannjjm 1254 5 , , , cord-023095-4dannjjm 1254 6 in in IN cord-023095-4dannjjm 1254 7 contrast contrast NN cord-023095-4dannjjm 1254 8 with with IN cord-023095-4dannjjm 1254 9 GLUT4 GLUT4 NNP cord-023095-4dannjjm 1254 10 , , , cord-023095-4dannjjm 1254 11 GLUT12 GLUT12 NNP cord-023095-4dannjjm 1254 12 does do VBZ cord-023095-4dannjjm 1254 13 not not RB cord-023095-4dannjjm 1254 14 appear appear VB cord-023095-4dannjjm 1254 15 to to TO cord-023095-4dannjjm 1254 16 contribute contribute VB cord-023095-4dannjjm 1254 17 to to IN cord-023095-4dannjjm 1254 18 glucose glucose NN cord-023095-4dannjjm 1254 19 transport transport NN cord-023095-4dannjjm 1254 20 alterations alteration NNS cord-023095-4dannjjm 1254 21 during during IN cord-023095-4dannjjm 1254 22 naturally naturally RB cord-023095-4dannjjm 1254 23 - - HYPH cord-023095-4dannjjm 1254 24 occurring occur VBG cord-023095-4dannjjm 1254 25 equine equine NN cord-023095-4dannjjm 1254 26 IR IR NNP cord-023095-4dannjjm 1254 27 . . . cord-023095-4dannjjm 1255 1 Insulin insulin NN cord-023095-4dannjjm 1255 2 resistance resistance NN cord-023095-4dannjjm 1255 3 ( ( -LRB- cord-023095-4dannjjm 1255 4 IR IR NNP cord-023095-4dannjjm 1255 5 ) ) -RRB- cord-023095-4dannjjm 1255 6 , , , cord-023095-4dannjjm 1255 7 characterized characterize VBN cord-023095-4dannjjm 1255 8 by by IN cord-023095-4dannjjm 1255 9 exaggerated exaggerated JJ cord-023095-4dannjjm 1255 10 glycemic glycemic NNP cord-023095-4dannjjm 1255 11 or or CC cord-023095-4dannjjm 1255 12 insulinemic insulinemic NNP cord-023095-4dannjjm 1255 13 responses response NNS cord-023095-4dannjjm 1255 14 to to IN cord-023095-4dannjjm 1255 15 glucose glucose NN cord-023095-4dannjjm 1255 16 challenge challenge NN cord-023095-4dannjjm 1255 17 , , , cord-023095-4dannjjm 1255 18 is be VBZ cord-023095-4dannjjm 1255 19 a a DT cord-023095-4dannjjm 1255 20 key key JJ cord-023095-4dannjjm 1255 21 metabolic metabolic JJ cord-023095-4dannjjm 1255 22 disturbance disturbance NN cord-023095-4dannjjm 1255 23 in in IN cord-023095-4dannjjm 1255 24 horses horse NNS cord-023095-4dannjjm 1255 25 that that WDT cord-023095-4dannjjm 1255 26 develop develop VBP cord-023095-4dannjjm 1255 27 obesity obesity NN cord-023095-4dannjjm 1255 28 - - HYPH cord-023095-4dannjjm 1255 29 associated associate VBN cord-023095-4dannjjm 1255 30 laminitis laminitis NN cord-023095-4dannjjm 1255 31 . . . cord-023095-4dannjjm 1256 1 In in IN cord-023095-4dannjjm 1256 2 addition addition NN cord-023095-4dannjjm 1256 3 to to IN cord-023095-4dannjjm 1256 4 obesity obesity NN cord-023095-4dannjjm 1256 5 , , , cord-023095-4dannjjm 1256 6 diet diet NN cord-023095-4dannjjm 1256 7 and and CC cord-023095-4dannjjm 1256 8 age age NN cord-023095-4dannjjm 1256 9 have have VBP cord-023095-4dannjjm 1256 10 been be VBN cord-023095-4dannjjm 1256 11 demonstrated demonstrate VBN cord-023095-4dannjjm 1256 12 to to TO cord-023095-4dannjjm 1256 13 affect affect VB cord-023095-4dannjjm 1256 14 tissue tissue NN cord-023095-4dannjjm 1256 15 sensitivity sensitivity NN cord-023095-4dannjjm 1256 16 to to IN cord-023095-4dannjjm 1256 17 insulin insulin NN cord-023095-4dannjjm 1256 18 in in IN cord-023095-4dannjjm 1256 19 other other JJ cord-023095-4dannjjm 1256 20 species specie NNS cord-023095-4dannjjm 1256 21 but but CC cord-023095-4dannjjm 1256 22 these these DT cord-023095-4dannjjm 1256 23 factors factor NNS cord-023095-4dannjjm 1256 24 have have VBP cord-023095-4dannjjm 1256 25 received receive VBN cord-023095-4dannjjm 1256 26 limited limited JJ cord-023095-4dannjjm 1256 27 investigation investigation NN cord-023095-4dannjjm 1256 28 in in IN cord-023095-4dannjjm 1256 29 horses horse NNS cord-023095-4dannjjm 1256 30 . . . cord-023095-4dannjjm 1257 1 We -PRON- PRP cord-023095-4dannjjm 1257 2 hypothesized hypothesize VBD cord-023095-4dannjjm 1257 3 that that IN cord-023095-4dannjjm 1257 4 there there EX cord-023095-4dannjjm 1257 5 would would MD cord-023095-4dannjjm 1257 6 be be VB cord-023095-4dannjjm 1257 7 greater great JJR cord-023095-4dannjjm 1257 8 glycemic glycemic NNP cord-023095-4dannjjm 1257 9 and and CC cord-023095-4dannjjm 1257 10 insulinemic insulinemic NNP cord-023095-4dannjjm 1257 11 responses response NNS cord-023095-4dannjjm 1257 12 to to IN cord-023095-4dannjjm 1257 13 a a DT cord-023095-4dannjjm 1257 14 sweet sweet JJ cord-023095-4dannjjm 1257 15 feed feed NN cord-023095-4dannjjm 1257 16 meal meal NN cord-023095-4dannjjm 1257 17 in in IN cord-023095-4dannjjm 1257 18 aged aged JJ cord-023095-4dannjjm 1257 19 horses horse NNS cord-023095-4dannjjm 1257 20 , , , cord-023095-4dannjjm 1257 21 as as IN cord-023095-4dannjjm 1257 22 compared compare VBN cord-023095-4dannjjm 1257 23 to to IN cord-023095-4dannjjm 1257 24 adult adult NN cord-023095-4dannjjm 1257 25 horses horse NNS cord-023095-4dannjjm 1257 26 , , , cord-023095-4dannjjm 1257 27 as as RB cord-023095-4dannjjm 1257 28 well well RB cord-023095-4dannjjm 1257 29 as as IN cord-023095-4dannjjm 1257 30 in in IN cord-023095-4dannjjm 1257 31 horses horse NNS cord-023095-4dannjjm 1257 32 adapted adapt VBN cord-023095-4dannjjm 1257 33 to to IN cord-023095-4dannjjm 1257 34 a a DT cord-023095-4dannjjm 1257 35 forage forage NN cord-023095-4dannjjm 1257 36 - - HYPH cord-023095-4dannjjm 1257 37 only only JJ cord-023095-4dannjjm 1257 38 diet diet NN cord-023095-4dannjjm 1257 39 . . . cord-023095-4dannjjm 1258 1 Three three CD cord-023095-4dannjjm 1258 2 diets diet NNS cord-023095-4dannjjm 1258 3 , , , cord-023095-4dannjjm 1258 4 grass grass NN cord-023095-4dannjjm 1258 5 hay hay NN cord-023095-4dannjjm 1258 6 only only RB cord-023095-4dannjjm 1258 7 , , , cord-023095-4dannjjm 1258 8 grass grass NN cord-023095-4dannjjm 1258 9 hay hay NN cord-023095-4dannjjm 1258 10 plus plus CC cord-023095-4dannjjm 1258 11 sweet sweet JJ cord-023095-4dannjjm 1258 12 feed feed NN cord-023095-4dannjjm 1258 13 ( ( -LRB- cord-023095-4dannjjm 1258 14 starch starch NN cord-023095-4dannjjm 1258 15 and and CC cord-023095-4dannjjm 1258 16 sugar sugar NN cord-023095-4dannjjm 1258 17 - - HYPH cord-023095-4dannjjm 1258 18 rich rich JJ cord-023095-4dannjjm 1258 19 , , , cord-023095-4dannjjm 1258 20 SS SS NNP cord-023095-4dannjjm 1258 21 ) ) -RRB- cord-023095-4dannjjm 1258 22 , , , cord-023095-4dannjjm 1258 23 and and CC cord-023095-4dannjjm 1258 24 grass grass NN cord-023095-4dannjjm 1258 25 hay hay NN cord-023095-4dannjjm 1258 26 plus plus CC cord-023095-4dannjjm 1258 27 a a DT cord-023095-4dannjjm 1258 28 fat fat NN cord-023095-4dannjjm 1258 29 and and CC cord-023095-4dannjjm 1258 30 fiber fiber NN cord-023095-4dannjjm 1258 31 ( ( -LRB- cord-023095-4dannjjm 1258 32 FF ff NN cord-023095-4dannjjm 1258 33 ) ) -RRB- cord-023095-4dannjjm 1258 34 feed feed NN cord-023095-4dannjjm 1258 35 , , , cord-023095-4dannjjm 1258 36 were be VBD cord-023095-4dannjjm 1258 37 fed feed VBN cord-023095-4dannjjm 1258 38 to to IN cord-023095-4dannjjm 1258 39 17 17 CD cord-023095-4dannjjm 1258 40 mares mare NNS cord-023095-4dannjjm 1258 41 , , , cord-023095-4dannjjm 1258 42 8 8 CD cord-023095-4dannjjm 1258 43 adult adult NN cord-023095-4dannjjm 1258 44 ( ( -LRB- cord-023095-4dannjjm 1258 45 5 5 CD cord-023095-4dannjjm 1258 46 - - SYM cord-023095-4dannjjm 1258 47 12 12 CD cord-023095-4dannjjm 1258 48 yr yr NN cord-023095-4dannjjm 1258 49 ) ) -RRB- cord-023095-4dannjjm 1258 50 and and CC cord-023095-4dannjjm 1258 51 9 9 CD cord-023095-4dannjjm 1258 52 aged aged JJ cord-023095-4dannjjm 1258 53 ( ( -LRB- cord-023095-4dannjjm 1258 54 4 4 CD cord-023095-4dannjjm 1258 55 19 19 CD cord-023095-4dannjjm 1258 56 yr yr NNS cord-023095-4dannjjm 1258 57 ) ) -RRB- cord-023095-4dannjjm 1258 58 , , , cord-023095-4dannjjm 1258 59 for for IN cord-023095-4dannjjm 1258 60 a a DT cord-023095-4dannjjm 1258 61 6-week 6-week JJ cord-023095-4dannjjm 1258 62 adaptation adaptation NN cord-023095-4dannjjm 1258 63 period period NN cord-023095-4dannjjm 1258 64 in in IN cord-023095-4dannjjm 1258 65 a a DT cord-023095-4dannjjm 1258 66 randomized randomized JJ cord-023095-4dannjjm 1258 67 design design NN cord-023095-4dannjjm 1258 68 . . . cord-023095-4dannjjm 1259 1 Glycemic Glycemic NNP cord-023095-4dannjjm 1259 2 and and CC cord-023095-4dannjjm 1259 3 insulinemic insulinemic NN cord-023095-4dannjjm 1259 4 responses response NNS cord-023095-4dannjjm 1259 5 to to IN cord-023095-4dannjjm 1259 6 a a DT cord-023095-4dannjjm 1259 7 standardized standardized JJ cord-023095-4dannjjm 1259 8 meal meal NN cord-023095-4dannjjm 1259 9 of of IN cord-023095-4dannjjm 1259 10 sweet sweet JJ cord-023095-4dannjjm 1259 11 feed feed NN cord-023095-4dannjjm 1259 12 ( ( -LRB- cord-023095-4dannjjm 1259 13 4 4 CD cord-023095-4dannjjm 1259 14 g g NN cord-023095-4dannjjm 1259 15 / / SYM cord-023095-4dannjjm 1259 16 kg kg NNP cord-023095-4dannjjm 1259 17 BW BW NNP cord-023095-4dannjjm 1259 18 offered offer VBD cord-023095-4dannjjm 1259 19 for for IN cord-023095-4dannjjm 1259 20 1 1 CD cord-023095-4dannjjm 1259 21 hour hour NN cord-023095-4dannjjm 1259 22 ) ) -RRB- cord-023095-4dannjjm 1259 23 were be VBD cord-023095-4dannjjm 1259 24 determined determine VBN cord-023095-4dannjjm 1259 25 for for IN cord-023095-4dannjjm 1259 26 6 6 CD cord-023095-4dannjjm 1259 27 hours hour NNS cord-023095-4dannjjm 1259 28 from from IN cord-023095-4dannjjm 1259 29 the the DT cord-023095-4dannjjm 1259 30 onset onset NN cord-023095-4dannjjm 1259 31 of of IN cord-023095-4dannjjm 1259 32 feeding feeding NN cord-023095-4dannjjm 1259 33 . . . cord-023095-4dannjjm 1260 1 Peak peak NN cord-023095-4dannjjm 1260 2 glucose glucose NN cord-023095-4dannjjm 1260 3 and and CC cord-023095-4dannjjm 1260 4 insulin insulin NN cord-023095-4dannjjm 1260 5 concentrations concentration NNS cord-023095-4dannjjm 1260 6 and and CC cord-023095-4dannjjm 1260 7 areas area NNS cord-023095-4dannjjm 1260 8 under under IN cord-023095-4dannjjm 1260 9 the the DT cord-023095-4dannjjm 1260 10 glucose glucose NN cord-023095-4dannjjm 1260 11 or or CC cord-023095-4dannjjm 1260 12 insulin insulin NN cord-023095-4dannjjm 1260 13 vs. vs. IN cord-023095-4dannjjm 1260 14 time time NN cord-023095-4dannjjm 1260 15 curves curve NNS cord-023095-4dannjjm 1260 16 ( ( -LRB- cord-023095-4dannjjm 1260 17 AUC AUC NNP cord-023095-4dannjjm 1260 18 - - HYPH cord-023095-4dannjjm 1260 19 G G NNP cord-023095-4dannjjm 1260 20 , , , cord-023095-4dannjjm 1260 21 mg/ mg/ NN cord-023095-4dannjjm 1260 22 dl/360 dl/360 NNP cord-023095-4dannjjm 1260 23 min min NNP cord-023095-4dannjjm 1260 24 , , , cord-023095-4dannjjm 1260 25 and and CC cord-023095-4dannjjm 1260 26 AUC AUC NNP cord-023095-4dannjjm 1260 27 - - HYPH cord-023095-4dannjjm 1260 28 I I NNP cord-023095-4dannjjm 1260 29 , , , cord-023095-4dannjjm 1260 30 mU mU NNP cord-023095-4dannjjm 1260 31 / / SYM cord-023095-4dannjjm 1260 32 ml/360 ml/360 NNPS cord-023095-4dannjjm 1260 33 min min NNP cord-023095-4dannjjm 1260 34 ) ) -RRB- cord-023095-4dannjjm 1260 35 were be VBD cord-023095-4dannjjm 1260 36 determined determine VBN cord-023095-4dannjjm 1260 37 and and CC cord-023095-4dannjjm 1260 38 data datum NNS cord-023095-4dannjjm 1260 39 were be VBD cord-023095-4dannjjm 1260 40 analyzed analyze VBN cord-023095-4dannjjm 1260 41 by by IN cord-023095-4dannjjm 1260 42 one one CD cord-023095-4dannjjm 1260 43 - - HYPH cord-023095-4dannjjm 1260 44 and and CC cord-023095-4dannjjm 1260 45 two two CD cord-023095-4dannjjm 1260 46 - - HYPH cord-023095-4dannjjm 1260 47 factor factor NN cord-023095-4dannjjm 1260 48 repeated repeat VBD cord-023095-4dannjjm 1260 49 measures measure NNS cord-023095-4dannjjm 1260 50 ANOVA ANOVA NNP cord-023095-4dannjjm 1260 51 . . . cord-023095-4dannjjm 1261 1 There there EX cord-023095-4dannjjm 1261 2 were be VBD cord-023095-4dannjjm 1261 3 no no DT cord-023095-4dannjjm 1261 4 differences difference NNS cord-023095-4dannjjm 1261 5 between between IN cord-023095-4dannjjm 1261 6 age age NN cord-023095-4dannjjm 1261 7 groups group NNS cord-023095-4dannjjm 1261 8 in in IN cord-023095-4dannjjm 1261 9 glycemic glycemic JJ cord-023095-4dannjjm 1261 10 responses response NNS cord-023095-4dannjjm 1261 11 to to IN cord-023095-4dannjjm 1261 12 any any DT cord-023095-4dannjjm 1261 13 of of IN cord-023095-4dannjjm 1261 14 the the DT cord-023095-4dannjjm 1261 15 diets diet NNS cord-023095-4dannjjm 1261 16 . . . cord-023095-4dannjjm 1262 1 However however RB cord-023095-4dannjjm 1262 2 , , , cord-023095-4dannjjm 1262 3 in in IN cord-023095-4dannjjm 1262 4 aged aged JJ cord-023095-4dannjjm 1262 5 horses horse NNS cord-023095-4dannjjm 1262 6 peak peak VBP cord-023095-4dannjjm 1262 7 glucose glucose NN cord-023095-4dannjjm 1262 8 concentration concentration NN cord-023095-4dannjjm 1262 9 ( ( -LRB- cord-023095-4dannjjm 1262 10 p p NN cord-023095-4dannjjm 1262 11 o o NN cord-023095-4dannjjm 1262 12 0.03 0.03 CD cord-023095-4dannjjm 1262 13 ) ) -RRB- cord-023095-4dannjjm 1262 14 and and CC cord-023095-4dannjjm 1262 15 AUC AUC NNP cord-023095-4dannjjm 1262 16 - - HYPH cord-023095-4dannjjm 1262 17 G G NNP cord-023095-4dannjjm 1262 18 ( ( -LRB- cord-023095-4dannjjm 1262 19 p p NN cord-023095-4dannjjm 1262 20 o o NN cord-023095-4dannjjm 1262 21 0.01 0.01 CD cord-023095-4dannjjm 1262 22 ) ) -RRB- cord-023095-4dannjjm 1262 23 were be VBD cord-023095-4dannjjm 1262 24 greater great JJR cord-023095-4dannjjm 1262 25 after after IN cord-023095-4dannjjm 1262 26 adaptation adaptation NN cord-023095-4dannjjm 1262 27 to to IN cord-023095-4dannjjm 1262 28 the the DT cord-023095-4dannjjm 1262 29 forage forage NN cord-023095-4dannjjm 1262 30 - - HYPH cord-023095-4dannjjm 1262 31 only only RB cord-023095-4dannjjm 1262 32 diet diet NN cord-023095-4dannjjm 1262 33 , , , cord-023095-4dannjjm 1262 34 as as IN cord-023095-4dannjjm 1262 35 compared compare VBN cord-023095-4dannjjm 1262 36 to to IN cord-023095-4dannjjm 1262 37 the the DT cord-023095-4dannjjm 1262 38 other other JJ cord-023095-4dannjjm 1262 39 two two CD cord-023095-4dannjjm 1262 40 diets diet NNS cord-023095-4dannjjm 1262 41 . . . cord-023095-4dannjjm 1263 1 In in IN cord-023095-4dannjjm 1263 2 contrast contrast NN cord-023095-4dannjjm 1263 3 , , , cord-023095-4dannjjm 1263 4 aged aged JJ cord-023095-4dannjjm 1263 5 horses horse NNS cord-023095-4dannjjm 1263 6 had have VBD cord-023095-4dannjjm 1263 7 a a DT cord-023095-4dannjjm 1263 8 greater great JJR cord-023095-4dannjjm 1263 9 peak peak NN cord-023095-4dannjjm 1263 10 insulin insulin NN cord-023095-4dannjjm 1263 11 concentration concentration NN cord-023095-4dannjjm 1263 12 ( ( -LRB- cord-023095-4dannjjm 1263 13 p p NN cord-023095-4dannjjm 1263 14 o o NN cord-023095-4dannjjm 1263 15 0.05 0.05 CD cord-023095-4dannjjm 1263 16 ) ) -RRB- cord-023095-4dannjjm 1263 17 and and CC cord-023095-4dannjjm 1263 18 AUC AUC NNP cord-023095-4dannjjm 1263 19 - - HYPH cord-023095-4dannjjm 1263 20 I I NNP cord-023095-4dannjjm 1263 21 ( ( -LRB- cord-023095-4dannjjm 1263 22 p p NN cord-023095-4dannjjm 1263 23 o o NN cord-023095-4dannjjm 1263 24 0.03 0.03 CD cord-023095-4dannjjm 1263 25 ) ) -RRB- cord-023095-4dannjjm 1263 26 than than IN cord-023095-4dannjjm 1263 27 adult adult NN cord-023095-4dannjjm 1263 28 horses horse NNS cord-023095-4dannjjm 1263 29 on on IN cord-023095-4dannjjm 1263 30 all all DT cord-023095-4dannjjm 1263 31 diets diet NNS cord-023095-4dannjjm 1263 32 but but CC cord-023095-4dannjjm 1263 33 no no DT cord-023095-4dannjjm 1263 34 differences difference NNS cord-023095-4dannjjm 1263 35 in in IN cord-023095-4dannjjm 1263 36 peak peak JJ cord-023095-4dannjjm 1263 37 insulin insulin NN cord-023095-4dannjjm 1263 38 concentration concentration NN cord-023095-4dannjjm 1263 39 or or CC cord-023095-4dannjjm 1263 40 AUC AUC NNP cord-023095-4dannjjm 1263 41 - - : cord-023095-4dannjjm 1263 42 I -PRON- PRP cord-023095-4dannjjm 1263 43 was be VBD cord-023095-4dannjjm 1263 44 found find VBN cord-023095-4dannjjm 1263 45 between between IN cord-023095-4dannjjm 1263 46 diets diet NNS cord-023095-4dannjjm 1263 47 within within IN cord-023095-4dannjjm 1263 48 age age NN cord-023095-4dannjjm 1263 49 groups group NNS cord-023095-4dannjjm 1263 50 . . . cord-023095-4dannjjm 1264 1 As as IN cord-023095-4dannjjm 1264 2 hypothesized hypothesize VBN cord-023095-4dannjjm 1264 3 , , , cord-023095-4dannjjm 1264 4 the the DT cord-023095-4dannjjm 1264 5 insulin insulin NN cord-023095-4dannjjm 1264 6 response response NN cord-023095-4dannjjm 1264 7 , , , cord-023095-4dannjjm 1264 8 but but CC cord-023095-4dannjjm 1264 9 not not RB cord-023095-4dannjjm 1264 10 the the DT cord-023095-4dannjjm 1264 11 glycemic glycemic JJ cord-023095-4dannjjm 1264 12 response response NN cord-023095-4dannjjm 1264 13 , , , cord-023095-4dannjjm 1264 14 to to IN cord-023095-4dannjjm 1264 15 a a DT cord-023095-4dannjjm 1264 16 sweet sweet JJ cord-023095-4dannjjm 1264 17 feed feed NN cord-023095-4dannjjm 1264 18 meal meal NN cord-023095-4dannjjm 1264 19 was be VBD cord-023095-4dannjjm 1264 20 greater great JJR cord-023095-4dannjjm 1264 21 in in IN cord-023095-4dannjjm 1264 22 aged aged JJ cord-023095-4dannjjm 1264 23 horses horse NNS cord-023095-4dannjjm 1264 24 , , , cord-023095-4dannjjm 1264 25 regardless regardless RB cord-023095-4dannjjm 1264 26 of of IN cord-023095-4dannjjm 1264 27 background background NN cord-023095-4dannjjm 1264 28 diet diet NN cord-023095-4dannjjm 1264 29 . . . cord-023095-4dannjjm 1265 1 Further further RB cord-023095-4dannjjm 1265 2 , , , cord-023095-4dannjjm 1265 3 the the DT cord-023095-4dannjjm 1265 4 glycemic glycemic JJ cord-023095-4dannjjm 1265 5 response response NN cord-023095-4dannjjm 1265 6 was be VBD cord-023095-4dannjjm 1265 7 greatest great JJS cord-023095-4dannjjm 1265 8 after after IN cord-023095-4dannjjm 1265 9 adaptation adaptation NN cord-023095-4dannjjm 1265 10 to to IN cord-023095-4dannjjm 1265 11 a a DT cord-023095-4dannjjm 1265 12 forage forage NN cord-023095-4dannjjm 1265 13 - - HYPH cord-023095-4dannjjm 1265 14 only only RB cord-023095-4dannjjm 1265 15 diet diet NN cord-023095-4dannjjm 1265 16 , , , cord-023095-4dannjjm 1265 17 but but CC cord-023095-4dannjjm 1265 18 this this DT cord-023095-4dannjjm 1265 19 finding finding NN cord-023095-4dannjjm 1265 20 was be VBD cord-023095-4dannjjm 1265 21 only only RB cord-023095-4dannjjm 1265 22 significant significant JJ cord-023095-4dannjjm 1265 23 in in IN cord-023095-4dannjjm 1265 24 aged aged JJ cord-023095-4dannjjm 1265 25 horses horse NNS cord-023095-4dannjjm 1265 26 . . . cord-023095-4dannjjm 1266 1 morbidity morbidity NN cord-023095-4dannjjm 1266 2 , , , cord-023095-4dannjjm 1266 3 mortality mortality NN cord-023095-4dannjjm 1266 4 , , , cord-023095-4dannjjm 1266 5 and and CC cord-023095-4dannjjm 1266 6 economic economic JJ cord-023095-4dannjjm 1266 7 loss loss NN cord-023095-4dannjjm 1266 8 to to IN cord-023095-4dannjjm 1266 9 the the DT cord-023095-4dannjjm 1266 10 equine equine NN cord-023095-4dannjjm 1266 11 industry industry NN cord-023095-4dannjjm 1266 12 . . . cord-023095-4dannjjm 1267 1 In in IN cord-023095-4dannjjm 1267 2 obese obese JJ cord-023095-4dannjjm 1267 3 humans human NNS cord-023095-4dannjjm 1267 4 and and CC cord-023095-4dannjjm 1267 5 rodent rodent NN cord-023095-4dannjjm 1267 6 models model NNS cord-023095-4dannjjm 1267 7 of of IN cord-023095-4dannjjm 1267 8 nutritional nutritional JJ cord-023095-4dannjjm 1267 9 obesity obesity NN cord-023095-4dannjjm 1267 10 , , , cord-023095-4dannjjm 1267 11 systemic systemic JJ cord-023095-4dannjjm 1267 12 insulin insulin NN cord-023095-4dannjjm 1267 13 resistance resistance NN cord-023095-4dannjjm 1267 14 and and CC cord-023095-4dannjjm 1267 15 hyperinsulinemia hyperinsulinemia NN cord-023095-4dannjjm 1267 16 are be VBP cord-023095-4dannjjm 1267 17 followed follow VBN cord-023095-4dannjjm 1267 18 temporally temporally RB cord-023095-4dannjjm 1267 19 in in IN cord-023095-4dannjjm 1267 20 a a DT cord-023095-4dannjjm 1267 21 majority majority NN cord-023095-4dannjjm 1267 22 of of IN cord-023095-4dannjjm 1267 23 individuals individual NNS cord-023095-4dannjjm 1267 24 by by IN cord-023095-4dannjjm 1267 25 decreased decrease VBD cord-023095-4dannjjm 1267 26 glucose glucose NN cord-023095-4dannjjm 1267 27 tolerance tolerance NN cord-023095-4dannjjm 1267 28 , , , cord-023095-4dannjjm 1267 29 pancreatic pancreatic JJ cord-023095-4dannjjm 1267 30 bcell bcell NN cord-023095-4dannjjm 1267 31 failure failure NN cord-023095-4dannjjm 1267 32 , , , cord-023095-4dannjjm 1267 33 and and CC cord-023095-4dannjjm 1267 34 type type NN cord-023095-4dannjjm 1267 35 II ii CD cord-023095-4dannjjm 1267 36 diabetes diabetes NN cord-023095-4dannjjm 1267 37 mellitus mellitus NN cord-023095-4dannjjm 1267 38 . . . cord-023095-4dannjjm 1268 1 In in IN cord-023095-4dannjjm 1268 2 stark stark JJ cord-023095-4dannjjm 1268 3 contrast contrast NN cord-023095-4dannjjm 1268 4 to to IN cord-023095-4dannjjm 1268 5 humans human NNS cord-023095-4dannjjm 1268 6 , , , cord-023095-4dannjjm 1268 7 obese obese JJ cord-023095-4dannjjm 1268 8 horses horse NNS cord-023095-4dannjjm 1268 9 and and CC cord-023095-4dannjjm 1268 10 ponies pony NNS cord-023095-4dannjjm 1268 11 chronically chronically RB cord-023095-4dannjjm 1268 12 remain remain VBP cord-023095-4dannjjm 1268 13 in in IN cord-023095-4dannjjm 1268 14 what what WP cord-023095-4dannjjm 1268 15 is be VBZ cord-023095-4dannjjm 1268 16 termed term VBN cord-023095-4dannjjm 1268 17 a a DT cord-023095-4dannjjm 1268 18 ' ' `` cord-023095-4dannjjm 1268 19 ' ' `` cord-023095-4dannjjm 1268 20 prediabetic prediabetic JJ cord-023095-4dannjjm 1268 21 ' ' '' cord-023095-4dannjjm 1268 22 ' ' '' cord-023095-4dannjjm 1268 23 state state NN cord-023095-4dannjjm 1268 24 in in IN cord-023095-4dannjjm 1268 25 human human JJ cord-023095-4dannjjm 1268 26 IR IR NNP cord-023095-4dannjjm 1268 27 , , , cord-023095-4dannjjm 1268 28 characterized characterize VBN cord-023095-4dannjjm 1268 29 by by IN cord-023095-4dannjjm 1268 30 hyperinsulinemic hyperinsulinemic NNP cord-023095-4dannjjm 1268 31 euglycemia euglycemia NNP cord-023095-4dannjjm 1268 32 . . . cord-023095-4dannjjm 1269 1 Few few JJ cord-023095-4dannjjm 1269 2 data datum NNS cord-023095-4dannjjm 1269 3 exist exist VBP cord-023095-4dannjjm 1269 4 describing describe VBG cord-023095-4dannjjm 1269 5 the the DT cord-023095-4dannjjm 1269 6 biology biology NN cord-023095-4dannjjm 1269 7 of of IN cord-023095-4dannjjm 1269 8 the the DT cord-023095-4dannjjm 1269 9 equine equine JJ cord-023095-4dannjjm 1269 10 endocrine endocrine JJ cord-023095-4dannjjm 1269 11 pancreas pancrea NNS cord-023095-4dannjjm 1269 12 in in IN cord-023095-4dannjjm 1269 13 the the DT cord-023095-4dannjjm 1269 14 chronically chronically RB cord-023095-4dannjjm 1269 15 IR IR NNP cord-023095-4dannjjm 1269 16 animal animal NN cord-023095-4dannjjm 1269 17 that that WDT cord-023095-4dannjjm 1269 18 may may MD cord-023095-4dannjjm 1269 19 both both DT cord-023095-4dannjjm 1269 20 : : : cord-023095-4dannjjm 1269 21 1 1 LS cord-023095-4dannjjm 1269 22 ) ) -RRB- cord-023095-4dannjjm 1269 23 explain explain VB cord-023095-4dannjjm 1269 24 this this DT cord-023095-4dannjjm 1269 25 unique unique JJ cord-023095-4dannjjm 1269 26 equine equine JJ cord-023095-4dannjjm 1269 27 endocrine endocrine JJ cord-023095-4dannjjm 1269 28 physiology physiology NN cord-023095-4dannjjm 1269 29 and and CC cord-023095-4dannjjm 1269 30 2 2 LS cord-023095-4dannjjm 1269 31 ) ) -RRB- cord-023095-4dannjjm 1269 32 characterize characterize VB cord-023095-4dannjjm 1269 33 the the DT cord-023095-4dannjjm 1269 34 animal animal NN cord-023095-4dannjjm 1269 35 at at IN cord-023095-4dannjjm 1269 36 - - HYPH cord-023095-4dannjjm 1269 37 risk risk NN cord-023095-4dannjjm 1269 38 for for IN cord-023095-4dannjjm 1269 39 hyperinsulinemia hyperinsulinemia NN cord-023095-4dannjjm 1269 40 - - HYPH cord-023095-4dannjjm 1269 41 associated associate VBN cord-023095-4dannjjm 1269 42 laminitis laminitis NN cord-023095-4dannjjm 1269 43 . . . cord-023095-4dannjjm 1270 1 The the DT cord-023095-4dannjjm 1270 2 purpose purpose NN cord-023095-4dannjjm 1270 3 of of IN cord-023095-4dannjjm 1270 4 the the DT cord-023095-4dannjjm 1270 5 study study NN cord-023095-4dannjjm 1270 6 reported report VBN cord-023095-4dannjjm 1270 7 here here RB cord-023095-4dannjjm 1270 8 was be VBD cord-023095-4dannjjm 1270 9 to to TO cord-023095-4dannjjm 1270 10 characterize characterize VB cord-023095-4dannjjm 1270 11 the the DT cord-023095-4dannjjm 1270 12 morphology morphology NN cord-023095-4dannjjm 1270 13 and and CC cord-023095-4dannjjm 1270 14 physiology physiology NN cord-023095-4dannjjm 1270 15 of of IN cord-023095-4dannjjm 1270 16 the the DT cord-023095-4dannjjm 1270 17 equine equine JJ cord-023095-4dannjjm 1270 18 endocrine endocrine JJ cord-023095-4dannjjm 1270 19 pancreas pancrea NNS cord-023095-4dannjjm 1270 20 in in IN cord-023095-4dannjjm 1270 21 response response NN cord-023095-4dannjjm 1270 22 to to IN cord-023095-4dannjjm 1270 23 a a DT cord-023095-4dannjjm 1270 24 dietary dietary JJ cord-023095-4dannjjm 1270 25 carbohydrate carbohydrate NN cord-023095-4dannjjm 1270 26 challenge challenge NN cord-023095-4dannjjm 1270 27 . . . cord-023095-4dannjjm 1271 1 Twenty twenty CD cord-023095-4dannjjm 1271 2 - - HYPH cord-023095-4dannjjm 1271 3 two two CD cord-023095-4dannjjm 1271 4 mixedbreed mixedbreed NN cord-023095-4dannjjm 1271 5 ponies pony NNS cord-023095-4dannjjm 1271 6 ( ( -LRB- cord-023095-4dannjjm 1271 7 body body NN cord-023095-4dannjjm 1271 8 weight weight NN cord-023095-4dannjjm 1272 1 266.6 266.6 CD cord-023095-4dannjjm 1272 2 AE AE NNP cord-023095-4dannjjm 1272 3 170.5 170.5 CD cord-023095-4dannjjm 1272 4 kg kg NNP cord-023095-4dannjjm 1272 5 ) ) -RRB- cord-023095-4dannjjm 1272 6 were be VBD cord-023095-4dannjjm 1272 7 conditioned condition VBN cord-023095-4dannjjm 1272 8 to to IN cord-023095-4dannjjm 1272 9 a a DT cord-023095-4dannjjm 1272 10 diet diet NN cord-023095-4dannjjm 1272 11 of of IN cord-023095-4dannjjm 1272 12 chopped chop VBN cord-023095-4dannjjm 1272 13 hay hay NN cord-023095-4dannjjm 1272 14 ( ( -LRB- cord-023095-4dannjjm 1272 15 NSC NSC NNP cord-023095-4dannjjm 1272 16 $ $ $ cord-023095-4dannjjm 1272 17 6 6 CD cord-023095-4dannjjm 1272 18 % % NN cord-023095-4dannjjm 1272 19 on on IN cord-023095-4dannjjm 1272 20 DM DM NNP cord-023095-4dannjjm 1272 21 basis basis NN cord-023095-4dannjjm 1272 22 ) ) -RRB- cord-023095-4dannjjm 1272 23 for for IN cord-023095-4dannjjm 1272 24 4 4 CD cord-023095-4dannjjm 1272 25 weeks week NNS cord-023095-4dannjjm 1272 26 ; ; : cord-023095-4dannjjm 1272 27 following follow VBG cord-023095-4dannjjm 1272 28 conditioning conditioning NN cord-023095-4dannjjm 1272 29 , , , cord-023095-4dannjjm 1272 30 ponies pony NNS cord-023095-4dannjjm 1272 31 either either CC cord-023095-4dannjjm 1272 32 remained remain VBD cord-023095-4dannjjm 1272 33 on on IN cord-023095-4dannjjm 1272 34 the the DT cord-023095-4dannjjm 1272 35 control control NN cord-023095-4dannjjm 1272 36 diet diet NN cord-023095-4dannjjm 1272 37 ( ( -LRB- cord-023095-4dannjjm 1272 38 n n NN cord-023095-4dannjjm 1272 39 5 5 CD cord-023095-4dannjjm 1272 40 11 11 CD cord-023095-4dannjjm 1272 41 ) ) -RRB- cord-023095-4dannjjm 1272 42 , , , cord-023095-4dannjjm 1272 43 or or CC cord-023095-4dannjjm 1272 44 received receive VBD cord-023095-4dannjjm 1272 45 the the DT cord-023095-4dannjjm 1272 46 same same JJ cord-023095-4dannjjm 1272 47 hay hay NN cord-023095-4dannjjm 1272 48 supplemented supplement VBN cord-023095-4dannjjm 1272 49 with with IN cord-023095-4dannjjm 1272 50 sweet sweet JJ cord-023095-4dannjjm 1272 51 feed feed NN cord-023095-4dannjjm 1272 52 and and CC cord-023095-4dannjjm 1272 53 oligofructose oligofructose JJ cord-023095-4dannjjm 1272 54 ( ( -LRB- cord-023095-4dannjjm 1272 55 total total JJ cord-023095-4dannjjm 1272 56 diet diet NN cord-023095-4dannjjm 1272 57 $ $ $ cord-023095-4dannjjm 1272 58 42 42 CD cord-023095-4dannjjm 1272 59 % % NN cord-023095-4dannjjm 1272 60 NSC NSC NNP cord-023095-4dannjjm 1272 61 ; ; : cord-023095-4dannjjm 1272 62 n n NN cord-023095-4dannjjm 1272 63 5 5 CD cord-023095-4dannjjm 1272 64 11 11 CD cord-023095-4dannjjm 1272 65 ) ) -RRB- cord-023095-4dannjjm 1272 66 for for IN cord-023095-4dannjjm 1272 67 7 7 CD cord-023095-4dannjjm 1272 68 days day NNS cord-023095-4dannjjm 1272 69 . . . cord-023095-4dannjjm 1273 1 Serum serum NN cord-023095-4dannjjm 1273 2 insulin insulin NN cord-023095-4dannjjm 1273 3 concentrations concentration NNS cord-023095-4dannjjm 1273 4 were be VBD cord-023095-4dannjjm 1273 5 measured measure VBN cord-023095-4dannjjm 1273 6 prior prior RB cord-023095-4dannjjm 1273 7 to to IN cord-023095-4dannjjm 1273 8 and and CC cord-023095-4dannjjm 1273 9 after after IN cord-023095-4dannjjm 1273 10 completion completion NN cord-023095-4dannjjm 1273 11 of of IN cord-023095-4dannjjm 1273 12 the the DT cord-023095-4dannjjm 1273 13 feeding feeding NN cord-023095-4dannjjm 1273 14 protocol protocol NN cord-023095-4dannjjm 1273 15 . . . cord-023095-4dannjjm 1274 1 At at IN cord-023095-4dannjjm 1274 2 the the DT cord-023095-4dannjjm 1274 3 end end NN cord-023095-4dannjjm 1274 4 of of IN cord-023095-4dannjjm 1274 5 the the DT cord-023095-4dannjjm 1274 6 feeding feeding NN cord-023095-4dannjjm 1274 7 protocol protocol NN cord-023095-4dannjjm 1274 8 , , , cord-023095-4dannjjm 1274 9 sections section NNS cord-023095-4dannjjm 1274 10 of of IN cord-023095-4dannjjm 1274 11 numerous numerous JJ cord-023095-4dannjjm 1274 12 tissues tissue NNS cord-023095-4dannjjm 1274 13 , , , cord-023095-4dannjjm 1274 14 including include VBG cord-023095-4dannjjm 1274 15 pancreas pancrea NNS cord-023095-4dannjjm 1274 16 , , , cord-023095-4dannjjm 1274 17 were be VBD cord-023095-4dannjjm 1274 18 collected collect VBN cord-023095-4dannjjm 1274 19 immediately immediately RB cord-023095-4dannjjm 1274 20 following follow VBG cord-023095-4dannjjm 1274 21 euthanasia euthanasia NN cord-023095-4dannjjm 1274 22 . . . cord-023095-4dannjjm 1275 1 The the DT cord-023095-4dannjjm 1275 2 samples sample NNS cord-023095-4dannjjm 1275 3 were be VBD cord-023095-4dannjjm 1275 4 formalin formalin NN cord-023095-4dannjjm 1275 5 - - HYPH cord-023095-4dannjjm 1275 6 fixed fix VBN cord-023095-4dannjjm 1275 7 for for IN cord-023095-4dannjjm 1275 8 48 48 CD cord-023095-4dannjjm 1275 9 hours hour NNS cord-023095-4dannjjm 1275 10 , , , cord-023095-4dannjjm 1275 11 transferred transfer VBN cord-023095-4dannjjm 1275 12 to to IN cord-023095-4dannjjm 1275 13 70 70 CD cord-023095-4dannjjm 1275 14 % % NN cord-023095-4dannjjm 1275 15 ethanol ethanol NN cord-023095-4dannjjm 1275 16 , , , cord-023095-4dannjjm 1275 17 and and CC cord-023095-4dannjjm 1275 18 paraffin paraffin NN cord-023095-4dannjjm 1275 19 - - HYPH cord-023095-4dannjjm 1275 20 embedded embed VBN cord-023095-4dannjjm 1275 21 . . . cord-023095-4dannjjm 1276 1 Immunohistochemistry Immunohistochemistry NNP cord-023095-4dannjjm 1276 2 was be VBD cord-023095-4dannjjm 1276 3 performed perform VBN cord-023095-4dannjjm 1276 4 on on IN cord-023095-4dannjjm 1276 5 pancreas pancreas NN cord-023095-4dannjjm 1276 6 sections section NNS cord-023095-4dannjjm 1276 7 using use VBG cord-023095-4dannjjm 1276 8 a a DT cord-023095-4dannjjm 1276 9 commerciallyavailable commerciallyavailable JJ cord-023095-4dannjjm 1276 10 anti anti JJ cord-023095-4dannjjm 1276 11 - - JJ cord-023095-4dannjjm 1276 12 insulin insulin JJ cord-023095-4dannjjm 1276 13 antibody antibody NN cord-023095-4dannjjm 1276 14 ( ( -LRB- cord-023095-4dannjjm 1276 15 Abcam Abcam NNP cord-023095-4dannjjm 1276 16 ) ) -RRB- cord-023095-4dannjjm 1276 17 , , , cord-023095-4dannjjm 1276 18 and and CC cord-023095-4dannjjm 1276 19 measurements measurement NNS cord-023095-4dannjjm 1276 20 of of IN cord-023095-4dannjjm 1276 21 islet islet NN cord-023095-4dannjjm 1276 22 surface surface NN cord-023095-4dannjjm 1276 23 area area NN cord-023095-4dannjjm 1276 24 and and CC cord-023095-4dannjjm 1276 25 b b NN cord-023095-4dannjjm 1276 26 - - HYPH cord-023095-4dannjjm 1276 27 cell cell NN cord-023095-4dannjjm 1276 28 surface surface NN cord-023095-4dannjjm 1276 29 area area NN cord-023095-4dannjjm 1276 30 were be VBD cord-023095-4dannjjm 1276 31 performed perform VBN cord-023095-4dannjjm 1276 32 ( ( -LRB- cord-023095-4dannjjm 1276 33 n n NN cord-023095-4dannjjm 1276 34 5 5 CD cord-023095-4dannjjm 1276 35 10 10 CD cord-023095-4dannjjm 1276 36 islets islet NNS cord-023095-4dannjjm 1276 37 per per IN cord-023095-4dannjjm 1276 38 tissue tissue NN cord-023095-4dannjjm 1276 39 section section NN cord-023095-4dannjjm 1276 40 ) ) -RRB- cord-023095-4dannjjm 1276 41 using use VBG cord-023095-4dannjjm 1276 42 a a DT cord-023095-4dannjjm 1276 43 commercially commercially RB cord-023095-4dannjjm 1276 44 - - HYPH cord-023095-4dannjjm 1276 45 available available JJ cord-023095-4dannjjm 1276 46 computer computer NN cord-023095-4dannjjm 1276 47 software software NN cord-023095-4dannjjm 1276 48 program program NN cord-023095-4dannjjm 1276 49 ( ( -LRB- cord-023095-4dannjjm 1276 50 Image Image NNP cord-023095-4dannjjm 1276 51 J J NNP cord-023095-4dannjjm 1276 52 ) ) -RRB- cord-023095-4dannjjm 1276 53 . . . cord-023095-4dannjjm 1277 1 There there EX cord-023095-4dannjjm 1277 2 was be VBD cord-023095-4dannjjm 1277 3 a a DT cord-023095-4dannjjm 1277 4 trend trend NN cord-023095-4dannjjm 1277 5 for for IN cord-023095-4dannjjm 1277 6 greater great JJR cord-023095-4dannjjm 1277 7 total total JJ cord-023095-4dannjjm 1277 8 islet islet NN cord-023095-4dannjjm 1277 9 surface surface NN cord-023095-4dannjjm 1277 10 area area NN cord-023095-4dannjjm 1277 11 in in IN cord-023095-4dannjjm 1277 12 pancreatic pancreatic JJ cord-023095-4dannjjm 1277 13 tissue tissue NN cord-023095-4dannjjm 1277 14 from from IN cord-023095-4dannjjm 1277 15 ponies pony NNS cord-023095-4dannjjm 1277 16 fed feed VBD cord-023095-4dannjjm 1277 17 the the DT cord-023095-4dannjjm 1277 18 high high JJ cord-023095-4dannjjm 1277 19 NSC NSC NNP cord-023095-4dannjjm 1277 20 diet diet NN cord-023095-4dannjjm 1277 21 when when WRB cord-023095-4dannjjm 1277 22 compared compare VBN cord-023095-4dannjjm 1277 23 to to IN cord-023095-4dannjjm 1277 24 the the DT cord-023095-4dannjjm 1277 25 ponies pony NNS cord-023095-4dannjjm 1277 26 on on IN cord-023095-4dannjjm 1277 27 the the DT cord-023095-4dannjjm 1277 28 hay hay NN cord-023095-4dannjjm 1277 29 diet diet NN cord-023095-4dannjjm 1277 30 ( ( -LRB- cord-023095-4dannjjm 1277 31 p p NN cord-023095-4dannjjm 1277 32 5 5 CD cord-023095-4dannjjm 1277 33 0.068 0.068 CD cord-023095-4dannjjm 1277 34 ) ) -RRB- cord-023095-4dannjjm 1277 35 ; ; : cord-023095-4dannjjm 1277 36 however however RB cord-023095-4dannjjm 1277 37 , , , cord-023095-4dannjjm 1277 38 no no DT cord-023095-4dannjjm 1277 39 difference difference NN cord-023095-4dannjjm 1277 40 was be VBD cord-023095-4dannjjm 1277 41 noted note VBN cord-023095-4dannjjm 1277 42 in in IN cord-023095-4dannjjm 1277 43 b b NN cord-023095-4dannjjm 1277 44 - - HYPH cord-023095-4dannjjm 1277 45 cell cell NN cord-023095-4dannjjm 1277 46 surface surface NN cord-023095-4dannjjm 1277 47 area area NN cord-023095-4dannjjm 1277 48 between between IN cord-023095-4dannjjm 1277 49 diet diet NN cord-023095-4dannjjm 1277 50 treatments treatment NNS cord-023095-4dannjjm 1277 51 ( ( -LRB- cord-023095-4dannjjm 1277 52 p p NN cord-023095-4dannjjm 1277 53 5 5 CD cord-023095-4dannjjm 1277 54 0.12 0.12 CD cord-023095-4dannjjm 1277 55 ) ) -RRB- cord-023095-4dannjjm 1277 56 . . . cord-023095-4dannjjm 1278 1 The the DT cord-023095-4dannjjm 1278 2 change change NN cord-023095-4dannjjm 1278 3 in in IN cord-023095-4dannjjm 1278 4 serum serum NN cord-023095-4dannjjm 1278 5 insulin insulin NN cord-023095-4dannjjm 1278 6 concentration concentration NN cord-023095-4dannjjm 1278 7 was be VBD cord-023095-4dannjjm 1278 8 significantly significantly RB cord-023095-4dannjjm 1278 9 greater great JJR cord-023095-4dannjjm 1278 10 in in IN cord-023095-4dannjjm 1278 11 the the DT cord-023095-4dannjjm 1278 12 high high JJ cord-023095-4dannjjm 1278 13 NSC NSC NNP cord-023095-4dannjjm 1278 14 - - HYPH cord-023095-4dannjjm 1278 15 fed fed NNP cord-023095-4dannjjm 1278 16 ponies pony NNS cord-023095-4dannjjm 1278 17 than than IN cord-023095-4dannjjm 1278 18 in in IN cord-023095-4dannjjm 1278 19 controls control NNS cord-023095-4dannjjm 1278 20 ( ( -LRB- cord-023095-4dannjjm 1278 21 403.8 403.8 CD cord-023095-4dannjjm 1278 22 1/-317.1 1/-317.1 CD cord-023095-4dannjjm 1278 23 mIU mIU NNP cord-023095-4dannjjm 1278 24 / / SYM cord-023095-4dannjjm 1278 25 L l NN cord-023095-4dannjjm 1278 26 vs. vs. IN cord-023095-4dannjjm 1278 27 1.00 1.00 CD cord-023095-4dannjjm 1278 28 1 1 CD cord-023095-4dannjjm 1278 29 / / SYM cord-023095-4dannjjm 1278 30 À à NN cord-023095-4dannjjm 1278 31 4.03 4.03 CD cord-023095-4dannjjm 1278 32 mIU mIU NNP cord-023095-4dannjjm 1278 33 / / SYM cord-023095-4dannjjm 1278 34 L l NN cord-023095-4dannjjm 1278 35 ; ; : cord-023095-4dannjjm 1278 36 p p NN cord-023095-4dannjjm 1278 37 5 5 CD cord-023095-4dannjjm 1278 38 0.002 0.002 CD cord-023095-4dannjjm 1278 39 ) ) -RRB- cord-023095-4dannjjm 1278 40 ; ; : cord-023095-4dannjjm 1278 41 however however RB cord-023095-4dannjjm 1278 42 , , , cord-023095-4dannjjm 1278 43 this this DT cord-023095-4dannjjm 1278 44 variable variable NN cord-023095-4dannjjm 1278 45 was be VBD cord-023095-4dannjjm 1278 46 not not RB cord-023095-4dannjjm 1278 47 correlated correlate VBN cord-023095-4dannjjm 1278 48 with with IN cord-023095-4dannjjm 1278 49 total total JJ cord-023095-4dannjjm 1278 50 islet islet NN cord-023095-4dannjjm 1278 51 surface surface NN cord-023095-4dannjjm 1278 52 area area NN cord-023095-4dannjjm 1278 53 ( ( -LRB- cord-023095-4dannjjm 1278 54 r r NN cord-023095-4dannjjm 1278 55 5 5 CD cord-023095-4dannjjm 1278 56 0.32 0.32 CD cord-023095-4dannjjm 1278 57 ; ; : cord-023095-4dannjjm 1278 58 p p NN cord-023095-4dannjjm 1278 59 5 5 CD cord-023095-4dannjjm 1278 60 0.17 0.17 CD cord-023095-4dannjjm 1278 61 ) ) -RRB- cord-023095-4dannjjm 1278 62 or or CC cord-023095-4dannjjm 1278 63 b b NN cord-023095-4dannjjm 1278 64 - - HYPH cord-023095-4dannjjm 1278 65 cell cell NN cord-023095-4dannjjm 1278 66 surface surface NN cord-023095-4dannjjm 1278 67 area area NN cord-023095-4dannjjm 1278 68 ( ( -LRB- cord-023095-4dannjjm 1278 69 r r NN cord-023095-4dannjjm 1278 70 5 5 CD cord-023095-4dannjjm 1278 71 0.25 0.25 CD cord-023095-4dannjjm 1278 72 ; ; : cord-023095-4dannjjm 1278 73 p p NN cord-023095-4dannjjm 1278 74 5 5 CD cord-023095-4dannjjm 1278 75 0.3 0.3 CD cord-023095-4dannjjm 1278 76 ) ) -RRB- cord-023095-4dannjjm 1278 77 . . . cord-023095-4dannjjm 1279 1 Due due IN cord-023095-4dannjjm 1279 2 to to IN cord-023095-4dannjjm 1279 3 the the DT cord-023095-4dannjjm 1279 4 relatively relatively RB cord-023095-4dannjjm 1279 5 modest modest JJ cord-023095-4dannjjm 1279 6 changes change NNS cord-023095-4dannjjm 1279 7 in in IN cord-023095-4dannjjm 1279 8 pancreatic pancreatic JJ cord-023095-4dannjjm 1279 9 islet islet NN cord-023095-4dannjjm 1279 10 surface surface NN cord-023095-4dannjjm 1279 11 area area NN cord-023095-4dannjjm 1279 12 that that WDT cord-023095-4dannjjm 1279 13 accompany accompany VBP cord-023095-4dannjjm 1279 14 marked marked JJ cord-023095-4dannjjm 1279 15 increases increase NNS cord-023095-4dannjjm 1279 16 in in IN cord-023095-4dannjjm 1279 17 serum serum NN cord-023095-4dannjjm 1279 18 insulin insulin NN cord-023095-4dannjjm 1279 19 concentrations concentration NNS cord-023095-4dannjjm 1279 20 in in IN cord-023095-4dannjjm 1279 21 ponies pony NNS cord-023095-4dannjjm 1279 22 fed feed VBD cord-023095-4dannjjm 1279 23 a a DT cord-023095-4dannjjm 1279 24 high high JJ cord-023095-4dannjjm 1279 25 NSC NSC NNP cord-023095-4dannjjm 1279 26 diet diet NN cord-023095-4dannjjm 1279 27 , , , cord-023095-4dannjjm 1279 28 it -PRON- PRP cord-023095-4dannjjm 1279 29 is be VBZ cord-023095-4dannjjm 1279 30 important important JJ cord-023095-4dannjjm 1279 31 to to TO cord-023095-4dannjjm 1279 32 assess assess VB cord-023095-4dannjjm 1279 33 both both DT cord-023095-4dannjjm 1279 34 b b NN cord-023095-4dannjjm 1279 35 - - HYPH cord-023095-4dannjjm 1279 36 cell cell NN cord-023095-4dannjjm 1279 37 function function NN cord-023095-4dannjjm 1279 38 and and CC cord-023095-4dannjjm 1279 39 insulin insulin NN cord-023095-4dannjjm 1279 40 clearance clearance NN cord-023095-4dannjjm 1279 41 mechanisms mechanism NNS cord-023095-4dannjjm 1279 42 in in IN cord-023095-4dannjjm 1279 43 future future JJ cord-023095-4dannjjm 1279 44 studies study NNS cord-023095-4dannjjm 1279 45 to to TO cord-023095-4dannjjm 1279 46 delineate delineate VB cord-023095-4dannjjm 1279 47 the the DT cord-023095-4dannjjm 1279 48 mechanism(s mechanism(s NNP cord-023095-4dannjjm 1279 49 ) ) -RRB- cord-023095-4dannjjm 1279 50 of of IN cord-023095-4dannjjm 1279 51 hyperinsulinemia hyperinsulinemia NN cord-023095-4dannjjm 1279 52 in in IN cord-023095-4dannjjm 1279 53 this this DT cord-023095-4dannjjm 1279 54 model model NN cord-023095-4dannjjm 1279 55 . . . cord-023095-4dannjjm 1280 1 Humans human NNS cord-023095-4dannjjm 1280 2 that that WDT cord-023095-4dannjjm 1280 3 suffer suffer VBP cord-023095-4dannjjm 1280 4 from from IN cord-023095-4dannjjm 1280 5 obesity obesity NN cord-023095-4dannjjm 1280 6 show show NN cord-023095-4dannjjm 1280 7 exaggerated exaggerate VBD cord-023095-4dannjjm 1280 8 inflammatory inflammatory JJ cord-023095-4dannjjm 1280 9 responses response NNS cord-023095-4dannjjm 1280 10 and and CC cord-023095-4dannjjm 1280 11 this this DT cord-023095-4dannjjm 1280 12 may may MD cord-023095-4dannjjm 1280 13 be be VB cord-023095-4dannjjm 1280 14 relevant relevant JJ cord-023095-4dannjjm 1280 15 to to IN cord-023095-4dannjjm 1280 16 the the DT cord-023095-4dannjjm 1280 17 association association NN cord-023095-4dannjjm 1280 18 between between IN cord-023095-4dannjjm 1280 19 increased increase VBN cord-023095-4dannjjm 1280 20 adiposity adiposity NN cord-023095-4dannjjm 1280 21 and and CC cord-023095-4dannjjm 1280 22 laminitis laminitis NN cord-023095-4dannjjm 1280 23 in in IN cord-023095-4dannjjm 1280 24 horses horse NNS cord-023095-4dannjjm 1280 25 with with IN cord-023095-4dannjjm 1280 26 Equine equine JJ cord-023095-4dannjjm 1280 27 Metabolic Metabolic NNP cord-023095-4dannjjm 1280 28 Syndrome Syndrome NNP cord-023095-4dannjjm 1280 29 ( ( -LRB- cord-023095-4dannjjm 1280 30 EMS EMS NNP cord-023095-4dannjjm 1280 31 ) ) -RRB- cord-023095-4dannjjm 1280 32 . . . cord-023095-4dannjjm 1281 1 This this DT cord-023095-4dannjjm 1281 2 study study NN cord-023095-4dannjjm 1281 3 was be VBD cord-023095-4dannjjm 1281 4 performed perform VBN cord-023095-4dannjjm 1281 5 to to TO cord-023095-4dannjjm 1281 6 test test VB cord-023095-4dannjjm 1281 7 the the DT cord-023095-4dannjjm 1281 8 hypothesis hypothesis NN cord-023095-4dannjjm 1281 9 that that IN cord-023095-4dannjjm 1281 10 inflammatory inflammatory JJ cord-023095-4dannjjm 1281 11 responses response NNS cord-023095-4dannjjm 1281 12 to to IN cord-023095-4dannjjm 1281 13 endotoxemia endotoxemia NN cord-023095-4dannjjm 1281 14 differ differ VBP cord-023095-4dannjjm 1281 15 between between IN cord-023095-4dannjjm 1281 16 healthy healthy JJ cord-023095-4dannjjm 1281 17 horses horse NNS cord-023095-4dannjjm 1281 18 and and CC cord-023095-4dannjjm 1281 19 those those DT cord-023095-4dannjjm 1281 20 affected affect VBN cord-023095-4dannjjm 1281 21 by by IN cord-023095-4dannjjm 1281 22 EMS EMS NNP cord-023095-4dannjjm 1281 23 . . . cord-023095-4dannjjm 1282 1 Six six CD cord-023095-4dannjjm 1282 2 healthy healthy JJ cord-023095-4dannjjm 1282 3 adult adult NN cord-023095-4dannjjm 1282 4 mares mare NNS cord-023095-4dannjjm 1282 5 and and CC cord-023095-4dannjjm 1282 6 6 6 CD cord-023095-4dannjjm 1282 7 horses horse NNS cord-023095-4dannjjm 1282 8 with with IN cord-023095-4dannjjm 1282 9 EMS EMS NNP cord-023095-4dannjjm 1282 10 received receive VBD cord-023095-4dannjjm 1282 11 an an DT cord-023095-4dannjjm 1282 12 intravenous intravenous JJ cord-023095-4dannjjm 1282 13 infusion infusion NN cord-023095-4dannjjm 1282 14 of of IN cord-023095-4dannjjm 1282 15 lipopolysaccharide lipopolysaccharide NN cord-023095-4dannjjm 1282 16 ( ( -LRB- cord-023095-4dannjjm 1282 17 LPS LPS NNP cord-023095-4dannjjm 1282 18 ; ; : cord-023095-4dannjjm 1282 19 20 20 CD cord-023095-4dannjjm 1282 20 ng ng NN cord-023095-4dannjjm 1282 21 / / SYM cord-023095-4dannjjm 1282 22 kg kg NNS cord-023095-4dannjjm 1282 23 in in IN cord-023095-4dannjjm 1282 24 60 60 CD cord-023095-4dannjjm 1282 25 mL ml NN cord-023095-4dannjjm 1282 26 sterile sterile JJ cord-023095-4dannjjm 1282 27 saline saline NN cord-023095-4dannjjm 1282 28 ) ) -RRB- cord-023095-4dannjjm 1282 29 or or CC cord-023095-4dannjjm 1282 30 saline saline NN cord-023095-4dannjjm 1282 31 alone alone RB cord-023095-4dannjjm 1282 32 . . . cord-023095-4dannjjm 1283 1 A a DT cord-023095-4dannjjm 1283 2 crossover crossover NN cord-023095-4dannjjm 1283 3 design design NN cord-023095-4dannjjm 1283 4 was be VBD cord-023095-4dannjjm 1283 5 employed employ VBN cord-023095-4dannjjm 1283 6 with with IN cord-023095-4dannjjm 1283 7 a a DT cord-023095-4dannjjm 1283 8 7-day 7-day JJ cord-023095-4dannjjm 1283 9 washout washout NN cord-023095-4dannjjm 1283 10 period period NN cord-023095-4dannjjm 1283 11 . . . cord-023095-4dannjjm 1284 1 Physical physical JJ cord-023095-4dannjjm 1284 2 examinations examination NNS cord-023095-4dannjjm 1284 3 were be VBD cord-023095-4dannjjm 1284 4 performed perform VBN cord-023095-4dannjjm 1284 5 hourly hourly JJ cord-023095-4dannjjm 1284 6 for for IN cord-023095-4dannjjm 1284 7 9h 9h CD cord-023095-4dannjjm 1284 8 and and CC cord-023095-4dannjjm 1284 9 whole whole JJ cord-023095-4dannjjm 1284 10 blood blood NN cord-023095-4dannjjm 1284 11 was be VBD cord-023095-4dannjjm 1284 12 collected collect VBN cord-023095-4dannjjm 1284 13 at at IN cord-023095-4dannjjm 1284 14 30 30 CD cord-023095-4dannjjm 1284 15 , , , cord-023095-4dannjjm 1284 16 60 60 CD cord-023095-4dannjjm 1284 17 , , , cord-023095-4dannjjm 1284 18 90 90 CD cord-023095-4dannjjm 1284 19 , , , cord-023095-4dannjjm 1284 20 120 120 CD cord-023095-4dannjjm 1284 21 , , , cord-023095-4dannjjm 1284 22 180 180 CD cord-023095-4dannjjm 1284 23 , , , cord-023095-4dannjjm 1284 24 and and CC cord-023095-4dannjjm 1284 25 240 240 CD cord-023095-4dannjjm 1284 26 min min NN cord-023095-4dannjjm 1284 27 for for IN cord-023095-4dannjjm 1284 28 assessment assessment NN cord-023095-4dannjjm 1284 29 of of IN cord-023095-4dannjjm 1284 30 inflammatory inflammatory JJ cord-023095-4dannjjm 1284 31 cytokine cytokine NN cord-023095-4dannjjm 1284 32 gene gene NN cord-023095-4dannjjm 1284 33 expression expression NN cord-023095-4dannjjm 1284 34 . . . cord-023095-4dannjjm 1285 1 A a DT cord-023095-4dannjjm 1285 2 liver liver NN cord-023095-4dannjjm 1285 3 biopsy biopsy NN cord-023095-4dannjjm 1285 4 was be VBD cord-023095-4dannjjm 1285 5 performed perform VBN cord-023095-4dannjjm 1285 6 between between IN cord-023095-4dannjjm 1285 7 240 240 CD cord-023095-4dannjjm 1285 8 and and CC cord-023095-4dannjjm 1285 9 360 360 CD cord-023095-4dannjjm 1285 10 min min NN cord-023095-4dannjjm 1285 11 postinfusion postinfusion NN cord-023095-4dannjjm 1285 12 . . . cord-023095-4dannjjm 1286 1 Data datum NNS cord-023095-4dannjjm 1286 2 were be VBD cord-023095-4dannjjm 1286 3 analyzed analyze VBN cord-023095-4dannjjm 1286 4 using use VBG cord-023095-4dannjjm 1286 5 mixed mixed JJ cord-023095-4dannjjm 1286 6 model model NN cord-023095-4dannjjm 1286 7 ANOVA ANOVA NNP cord-023095-4dannjjm 1286 8 . . . cord-023095-4dannjjm 1287 1 Mean mean JJ cord-023095-4dannjjm 1287 2 rectal rectal JJ cord-023095-4dannjjm 1287 3 temperature temperature NN cord-023095-4dannjjm 1287 4 , , , cord-023095-4dannjjm 1287 5 heart heart NN cord-023095-4dannjjm 1287 6 rate rate NN cord-023095-4dannjjm 1287 7 , , , cord-023095-4dannjjm 1287 8 and and CC cord-023095-4dannjjm 1287 9 respiratory respiratory JJ cord-023095-4dannjjm 1287 10 rate rate NN cord-023095-4dannjjm 1287 11 increased increase VBD cord-023095-4dannjjm 1287 12 following follow VBG cord-023095-4dannjjm 1287 13 LPS LPS NNP cord-023095-4dannjjm 1287 14 infusion infusion NN cord-023095-4dannjjm 1287 15 ( ( -LRB- cord-023095-4dannjjm 1287 16 treatment treatment NN cord-023095-4dannjjm 1287 17 Â â CD cord-023095-4dannjjm 1287 18 time time NN cord-023095-4dannjjm 1287 19 ; ; : cord-023095-4dannjjm 1287 20 P p NN cord-023095-4dannjjm 1287 21 o o NN cord-023095-4dannjjm 1287 22 0.001 0.001 CD cord-023095-4dannjjm 1287 23 ) ) -RRB- cord-023095-4dannjjm 1287 24 , , , cord-023095-4dannjjm 1287 25 with with IN cord-023095-4dannjjm 1287 26 higher high JJR cord-023095-4dannjjm 1287 27 heart heart NN cord-023095-4dannjjm 1287 28 ( ( -LRB- cord-023095-4dannjjm 1287 29 group group NN cord-023095-4dannjjm 1287 30 Â â CD cord-023095-4dannjjm 1287 31 treatment treatment NN cord-023095-4dannjjm 1287 32 ; ; : cord-023095-4dannjjm 1287 33 P p NN cord-023095-4dannjjm 1287 34 5 5 CD cord-023095-4dannjjm 1287 35 0.087 0.087 CD cord-023095-4dannjjm 1287 36 ) ) -RRB- cord-023095-4dannjjm 1287 37 and and CC cord-023095-4dannjjm 1287 38 respiratory respiratory JJ cord-023095-4dannjjm 1287 39 rates rate NNS cord-023095-4dannjjm 1287 40 ( ( -LRB- cord-023095-4dannjjm 1287 41 group group NN cord-023095-4dannjjm 1287 42 ; ; : cord-023095-4dannjjm 1287 43 P p NN cord-023095-4dannjjm 1287 44 5 5 CD cord-023095-4dannjjm 1287 45 0.017 0.017 CD cord-023095-4dannjjm 1287 46 ) ) -RRB- cord-023095-4dannjjm 1287 47 detected detect VBN cord-023095-4dannjjm 1287 48 in in IN cord-023095-4dannjjm 1287 49 EMS EMS NNP cord-023095-4dannjjm 1287 50 horses horse NNS cord-023095-4dannjjm 1287 51 . . . cord-023095-4dannjjm 1288 1 Lipopolysaccharide Lipopolysaccharide NNP cord-023095-4dannjjm 1288 2 infusion infusion NN cord-023095-4dannjjm 1288 3 significantly significantly RB cord-023095-4dannjjm 1288 4 increased increase VBD cord-023095-4dannjjm 1288 5 whole whole JJ cord-023095-4dannjjm 1288 6 blood blood NN cord-023095-4dannjjm 1288 7 gene gene NN cord-023095-4dannjjm 1288 8 expression expression NN cord-023095-4dannjjm 1288 9 of of IN cord-023095-4dannjjm 1288 10 tumor tumor NN cord-023095-4dannjjm 1288 11 necrosis necrosis NN cord-023095-4dannjjm 1288 12 factor factor NN cord-023095-4dannjjm 1288 13 a a NN cord-023095-4dannjjm 1288 14 ( ( -LRB- cord-023095-4dannjjm 1288 15 TNFa TNFa NNP cord-023095-4dannjjm 1288 16 ) ) -RRB- cord-023095-4dannjjm 1288 17 , , , cord-023095-4dannjjm 1288 18 interleukin interleukin FW cord-023095-4dannjjm 1288 19 ( ( -LRB- cord-023095-4dannjjm 1288 20 IL)-1b IL)-1b NNP cord-023095-4dannjjm 1288 21 ( ( -LRB- cord-023095-4dannjjm 1288 22 P p NN cord-023095-4dannjjm 1288 23 o o NN cord-023095-4dannjjm 1288 24 0.001 0.001 CD cord-023095-4dannjjm 1288 25 ) ) -RRB- cord-023095-4dannjjm 1288 26 , , , cord-023095-4dannjjm 1288 27 IL-6 IL-6 NNP cord-023095-4dannjjm 1288 28 ( ( -LRB- cord-023095-4dannjjm 1288 29 P p NN cord-023095-4dannjjm 1288 30 o o CD cord-023095-4dannjjm 1288 31 0.001 0.001 CD cord-023095-4dannjjm 1288 32 ) ) -RRB- cord-023095-4dannjjm 1288 33 , , . cord-023095-4dannjjm 1289 1 IL-8 IL-8 NNP cord-023095-4dannjjm 1289 2 ( ( -LRB- cord-023095-4dannjjm 1289 3 P p NN cord-023095-4dannjjm 1289 4 o o NN cord-023095-4dannjjm 1289 5 0.001 0.001 CD cord-023095-4dannjjm 1289 6 ) ) -RRB- cord-023095-4dannjjm 1289 7 , , , cord-023095-4dannjjm 1289 8 and and CC cord-023095-4dannjjm 1289 9 IL-10 IL-10 NNP cord-023095-4dannjjm 1289 10 ( ( -LRB- cord-023095-4dannjjm 1289 11 P p NN cord-023095-4dannjjm 1289 12 5 5 CD cord-023095-4dannjjm 1289 13 0.002 0.002 CD cord-023095-4dannjjm 1289 14 ) ) -RRB- cord-023095-4dannjjm 1289 15 , , , cord-023095-4dannjjm 1289 16 and and CC cord-023095-4dannjjm 1289 17 hepatic hepatic JJ cord-023095-4dannjjm 1289 18 gene gene NN cord-023095-4dannjjm 1289 19 expression expression NN cord-023095-4dannjjm 1289 20 of of IN cord-023095-4dannjjm 1289 21 IL-6 IL-6 NNP cord-023095-4dannjjm 1289 22 ( ( -LRB- cord-023095-4dannjjm 1289 23 P p NN cord-023095-4dannjjm 1289 24 o o CD cord-023095-4dannjjm 1289 25 0.001 0.001 CD cord-023095-4dannjjm 1289 26 ) ) -RRB- cord-023095-4dannjjm 1289 27 , , . cord-023095-4dannjjm 1290 1 IL-8 IL-8 NNP cord-023095-4dannjjm 1290 2 ( ( -LRB- cord-023095-4dannjjm 1290 3 P p NN cord-023095-4dannjjm 1290 4 o o NN cord-023095-4dannjjm 1290 5 0.001 0.001 CD cord-023095-4dannjjm 1290 6 ) ) -RRB- cord-023095-4dannjjm 1290 7 , , , cord-023095-4dannjjm 1290 8 and and CC cord-023095-4dannjjm 1290 9 IL-10 IL-10 NNP cord-023095-4dannjjm 1290 10 ( ( -LRB- cord-023095-4dannjjm 1290 11 P p NN cord-023095-4dannjjm 1290 12 5 5 CD cord-023095-4dannjjm 1290 13 0.016 0.016 CD cord-023095-4dannjjm 1290 14 ) ) -RRB- cord-023095-4dannjjm 1290 15 . . . cord-023095-4dannjjm 1291 1 Inflammatory inflammatory JJ cord-023095-4dannjjm 1291 2 gene gene NN cord-023095-4dannjjm 1291 3 expression expression NN cord-023095-4dannjjm 1291 4 did do VBD cord-023095-4dannjjm 1291 5 not not RB cord-023095-4dannjjm 1291 6 differ differ VB cord-023095-4dannjjm 1291 7 significantly significantly RB cord-023095-4dannjjm 1291 8 between between IN cord-023095-4dannjjm 1291 9 groups group NNS cord-023095-4dannjjm 1291 10 , , , cord-023095-4dannjjm 1291 11 so so RB cord-023095-4dannjjm 1291 12 our -PRON- PRP$ cord-023095-4dannjjm 1291 13 hypothesis hypothesis NN cord-023095-4dannjjm 1291 14 was be VBD cord-023095-4dannjjm 1291 15 not not RB cord-023095-4dannjjm 1291 16 supported support VBN cord-023095-4dannjjm 1291 17 . . . cord-023095-4dannjjm 1292 1 Heart heart NN cord-023095-4dannjjm 1292 2 rates rate NNS cord-023095-4dannjjm 1292 3 tended tend VBD cord-023095-4dannjjm 1292 4 to to TO cord-023095-4dannjjm 1292 5 be be VB cord-023095-4dannjjm 1292 6 higher high JJR cord-023095-4dannjjm 1292 7 when when WRB cord-023095-4dannjjm 1292 8 LPS LPS NNP cord-023095-4dannjjm 1292 9 was be VBD cord-023095-4dannjjm 1292 10 administered administer VBN cord-023095-4dannjjm 1292 11 to to IN cord-023095-4dannjjm 1292 12 horses horse NNS cord-023095-4dannjjm 1292 13 with with IN cord-023095-4dannjjm 1292 14 EMS EMS NNP cord-023095-4dannjjm 1292 15 . . . cord-023095-4dannjjm 1293 1 Elevated elevated JJ cord-023095-4dannjjm 1293 2 serum serum NN cord-023095-4dannjjm 1293 3 concentration concentration NN cord-023095-4dannjjm 1293 4 of of IN cord-023095-4dannjjm 1293 5 cardiac cardiac NN cord-023095-4dannjjm 1293 6 troponin troponin NN cord-023095-4dannjjm 1293 7 I -PRON- PRP cord-023095-4dannjjm 1293 8 ( ( -LRB- cord-023095-4dannjjm 1293 9 cTnI cTnI NNP cord-023095-4dannjjm 1293 10 ) ) -RRB- cord-023095-4dannjjm 1293 11 is be VBZ cord-023095-4dannjjm 1293 12 a a DT cord-023095-4dannjjm 1293 13 biomarker biomarker NN cord-023095-4dannjjm 1293 14 for for IN cord-023095-4dannjjm 1293 15 myocardial myocardial JJ cord-023095-4dannjjm 1293 16 damage damage NN cord-023095-4dannjjm 1293 17 in in IN cord-023095-4dannjjm 1293 18 horses horse NNS cord-023095-4dannjjm 1293 19 . . . cord-023095-4dannjjm 1294 1 Preferred preferred JJ cord-023095-4dannjjm 1294 2 times time NNS cord-023095-4dannjjm 1294 3 to to TO cord-023095-4dannjjm 1294 4 test test VB cord-023095-4dannjjm 1294 5 blood blood NN cord-023095-4dannjjm 1294 6 for for IN cord-023095-4dannjjm 1294 7 cTnI cTnI NNP cord-023095-4dannjjm 1294 8 levels level NNS cord-023095-4dannjjm 1294 9 following follow VBG cord-023095-4dannjjm 1294 10 athletic athletic JJ cord-023095-4dannjjm 1294 11 performance performance NN cord-023095-4dannjjm 1294 12 or or CC cord-023095-4dannjjm 1294 13 other other JJ cord-023095-4dannjjm 1294 14 events event NNS cord-023095-4dannjjm 1294 15 that that WDT cord-023095-4dannjjm 1294 16 may may MD cord-023095-4dannjjm 1294 17 cause cause VB cord-023095-4dannjjm 1294 18 myocardial myocardial JJ cord-023095-4dannjjm 1294 19 injury injury NN cord-023095-4dannjjm 1294 20 are be VBP cord-023095-4dannjjm 1294 21 not not RB cord-023095-4dannjjm 1294 22 yet yet RB cord-023095-4dannjjm 1294 23 established establish VBN cord-023095-4dannjjm 1294 24 and and CC cord-023095-4dannjjm 1294 25 would would MD cord-023095-4dannjjm 1294 26 be be VB cord-023095-4dannjjm 1294 27 affected affect VBN cord-023095-4dannjjm 1294 28 by by IN cord-023095-4dannjjm 1294 29 time time NN cord-023095-4dannjjm 1294 30 of of IN cord-023095-4dannjjm 1294 31 release release NN cord-023095-4dannjjm 1294 32 from from IN cord-023095-4dannjjm 1294 33 the the DT cord-023095-4dannjjm 1294 34 myocytes myocyte NNS cord-023095-4dannjjm 1294 35 , , , cord-023095-4dannjjm 1294 36 location location NN cord-023095-4dannjjm 1294 37 of of IN cord-023095-4dannjjm 1294 38 release release NN cord-023095-4dannjjm 1294 39 within within IN cord-023095-4dannjjm 1294 40 the the DT cord-023095-4dannjjm 1294 41 myocytes myocytes NN cord-023095-4dannjjm 1294 42 , , , cord-023095-4dannjjm 1294 43 duration duration NN cord-023095-4dannjjm 1294 44 of of IN cord-023095-4dannjjm 1294 45 release release NN cord-023095-4dannjjm 1294 46 and and CC cord-023095-4dannjjm 1294 47 half half JJ cord-023095-4dannjjm 1294 48 - - HYPH cord-023095-4dannjjm 1294 49 life life NN cord-023095-4dannjjm 1294 50 of of IN cord-023095-4dannjjm 1294 51 cTnI cTnI NNP cord-023095-4dannjjm 1294 52 in in IN cord-023095-4dannjjm 1294 53 the the DT cord-023095-4dannjjm 1294 54 horse horse NN cord-023095-4dannjjm 1294 55 . . . cord-023095-4dannjjm 1295 1 This this DT cord-023095-4dannjjm 1295 2 information information NN cord-023095-4dannjjm 1295 3 would would MD cord-023095-4dannjjm 1295 4 be be VB cord-023095-4dannjjm 1295 5 necessary necessary JJ cord-023095-4dannjjm 1295 6 to to TO cord-023095-4dannjjm 1295 7 more more RBR cord-023095-4dannjjm 1295 8 accurately accurately RB cord-023095-4dannjjm 1295 9 and and CC cord-023095-4dannjjm 1295 10 reliably reliably RB cord-023095-4dannjjm 1295 11 test test VB cord-023095-4dannjjm 1295 12 horses horse NNS cord-023095-4dannjjm 1295 13 for for IN cord-023095-4dannjjm 1295 14 myocardial myocardial JJ cord-023095-4dannjjm 1295 15 injury injury NN cord-023095-4dannjjm 1295 16 . . . cord-023095-4dannjjm 1296 1 The the DT cord-023095-4dannjjm 1296 2 aim aim NN cord-023095-4dannjjm 1296 3 of of IN cord-023095-4dannjjm 1296 4 this this DT cord-023095-4dannjjm 1296 5 study study NN cord-023095-4dannjjm 1296 6 was be VBD cord-023095-4dannjjm 1296 7 to to TO cord-023095-4dannjjm 1296 8 determine determine VB cord-023095-4dannjjm 1296 9 the the DT cord-023095-4dannjjm 1296 10 elimination elimination NN cord-023095-4dannjjm 1296 11 half half JJ cord-023095-4dannjjm 1296 12 - - HYPH cord-023095-4dannjjm 1296 13 life life NN cord-023095-4dannjjm 1296 14 ( ( -LRB- cord-023095-4dannjjm 1296 15 T1/2 T1/2 NNP cord-023095-4dannjjm 1296 16 ) ) -RRB- cord-023095-4dannjjm 1296 17 of of IN cord-023095-4dannjjm 1296 18 equine equine NN cord-023095-4dannjjm 1296 19 cTnI. ctni. ADD cord-023095-4dannjjm 1297 1 To to TO cord-023095-4dannjjm 1297 2 establish establish VB cord-023095-4dannjjm 1297 3 the the DT cord-023095-4dannjjm 1297 4 T1/2 t1/2 NN cord-023095-4dannjjm 1297 5 of of IN cord-023095-4dannjjm 1297 6 equine equine NN cord-023095-4dannjjm 1297 7 cTnI cTnI VBN cord-023095-4dannjjm 1297 8 in in IN cord-023095-4dannjjm 1297 9 horses horse NNS cord-023095-4dannjjm 1297 10 , , , cord-023095-4dannjjm 1297 11 cTnI cTnI NNP cord-023095-4dannjjm 1297 12 was be VBD cord-023095-4dannjjm 1297 13 recombinantly recombinantly RB cord-023095-4dannjjm 1297 14 expressed express VBN cord-023095-4dannjjm 1297 15 in in IN cord-023095-4dannjjm 1297 16 E.coli E.coli NNS cord-023095-4dannjjm 1297 17 . . . cord-023095-4dannjjm 1298 1 Two two CD cord-023095-4dannjjm 1298 2 healthy healthy JJ cord-023095-4dannjjm 1298 3 ponies pony NNS cord-023095-4dannjjm 1298 4 received receive VBD cord-023095-4dannjjm 1298 5 intravenous intravenous JJ cord-023095-4dannjjm 1298 6 injections injection NNS cord-023095-4dannjjm 1298 7 of of IN cord-023095-4dannjjm 1298 8 recombinant recombinant JJ cord-023095-4dannjjm 1298 9 equine equine NN cord-023095-4dannjjm 1298 10 cTnI cTnI NNP cord-023095-4dannjjm 1298 11 and and CC cord-023095-4dannjjm 1298 12 plasma plasma NN cord-023095-4dannjjm 1298 13 cTnI cTnI NNP cord-023095-4dannjjm 1298 14 concentrations concentration NNS cord-023095-4dannjjm 1298 15 were be VBD cord-023095-4dannjjm 1298 16 measured measure VBN cord-023095-4dannjjm 1298 17 with with IN cord-023095-4dannjjm 1298 18 a a DT cord-023095-4dannjjm 1298 19 point point NN cord-023095-4dannjjm 1298 20 - - HYPH cord-023095-4dannjjm 1298 21 of of IN cord-023095-4dannjjm 1298 22 - - HYPH cord-023095-4dannjjm 1298 23 care care NN cord-023095-4dannjjm 1298 24 cTnI cTnI NNP cord-023095-4dannjjm 1298 25 analyzer analyzer NN cord-023095-4dannjjm 1298 26 at at IN cord-023095-4dannjjm 1298 27 multiple multiple JJ cord-023095-4dannjjm 1298 28 time time NN cord-023095-4dannjjm 1298 29 points point NNS cord-023095-4dannjjm 1298 30 after after IN cord-023095-4dannjjm 1298 31 injection injection NN cord-023095-4dannjjm 1298 32 . . . cord-023095-4dannjjm 1299 1 Standard standard JJ cord-023095-4dannjjm 1299 2 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 1299 3 analysis analysis NN cord-023095-4dannjjm 1299 4 was be VBD cord-023095-4dannjjm 1299 5 performed perform VBN cord-023095-4dannjjm 1299 6 to to TO cord-023095-4dannjjm 1299 7 establish establish VB cord-023095-4dannjjm 1299 8 the the DT cord-023095-4dannjjm 1299 9 elimination elimination NN cord-023095-4dannjjm 1299 10 half half JJ cord-023095-4dannjjm 1299 11 - - HYPH cord-023095-4dannjjm 1299 12 life life NN cord-023095-4dannjjm 1299 13 of of IN cord-023095-4dannjjm 1299 14 cTnI. ctni. ADD cord-023095-4dannjjm 1300 1 For for IN cord-023095-4dannjjm 1300 2 comparative comparative JJ cord-023095-4dannjjm 1300 3 purposes purpose NNS cord-023095-4dannjjm 1300 4 , , , cord-023095-4dannjjm 1300 5 data datum NNS cord-023095-4dannjjm 1300 6 were be VBD cord-023095-4dannjjm 1300 7 subjected subject VBN cord-023095-4dannjjm 1300 8 to to IN cord-023095-4dannjjm 1300 9 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 1300 10 models model NNS cord-023095-4dannjjm 1300 11 describing describe VBG cord-023095-4dannjjm 1300 12 a a DT cord-023095-4dannjjm 1300 13 single single JJ cord-023095-4dannjjm 1300 14 versus versus IN cord-023095-4dannjjm 1300 15 biphasic biphasic JJ cord-023095-4dannjjm 1300 16 elimination elimination NN cord-023095-4dannjjm 1300 17 profile profile NN cord-023095-4dannjjm 1300 18 . . . cord-023095-4dannjjm 1301 1 Elimination elimination NN cord-023095-4dannjjm 1301 2 of of IN cord-023095-4dannjjm 1301 3 recombinant recombinant JJ cord-023095-4dannjjm 1301 4 equine equine NN cord-023095-4dannjjm 1301 5 cTnI cTnI NNP cord-023095-4dannjjm 1301 6 following follow VBG cord-023095-4dannjjm 1301 7 intravenous intravenous JJ cord-023095-4dannjjm 1301 8 administration administration NN cord-023095-4dannjjm 1301 9 exhibits exhibit VBZ cord-023095-4dannjjm 1301 10 a a DT cord-023095-4dannjjm 1301 11 short short JJ cord-023095-4dannjjm 1301 12 half half JJ cord-023095-4dannjjm 1301 13 - - HYPH cord-023095-4dannjjm 1301 14 life life NN cord-023095-4dannjjm 1301 15 . . . cord-023095-4dannjjm 1302 1 Establishing establish VBG cord-023095-4dannjjm 1302 2 the the DT cord-023095-4dannjjm 1302 3 T1/2 t1/2 NN cord-023095-4dannjjm 1302 4 of of IN cord-023095-4dannjjm 1302 5 troponin troponin JJ cord-023095-4dannjjm 1302 6 provides provide VBZ cord-023095-4dannjjm 1302 7 critical critical JJ cord-023095-4dannjjm 1302 8 information information NN cord-023095-4dannjjm 1302 9 in in IN cord-023095-4dannjjm 1302 10 understanding understand VBG cord-023095-4dannjjm 1302 11 the the DT cord-023095-4dannjjm 1302 12 clinical clinical JJ cord-023095-4dannjjm 1302 13 application application NN cord-023095-4dannjjm 1302 14 of of IN cord-023095-4dannjjm 1302 15 this this DT cord-023095-4dannjjm 1302 16 cardiac cardiac JJ cord-023095-4dannjjm 1302 17 biomarker biomarker NN cord-023095-4dannjjm 1302 18 in in IN cord-023095-4dannjjm 1302 19 clinical clinical JJ cord-023095-4dannjjm 1302 20 practice practice NN cord-023095-4dannjjm 1302 21 . . . cord-023095-4dannjjm 1303 1 This this DT cord-023095-4dannjjm 1303 2 study study NN cord-023095-4dannjjm 1303 3 describes describe VBZ cord-023095-4dannjjm 1303 4 a a DT cord-023095-4dannjjm 1303 5 true true JJ cord-023095-4dannjjm 1303 6 biological biological JJ cord-023095-4dannjjm 1303 7 cTnI cTnI VBN cord-023095-4dannjjm 1303 8 T1/2 t1/2 NN cord-023095-4dannjjm 1303 9 , , , cord-023095-4dannjjm 1303 10 which which WDT cord-023095-4dannjjm 1303 11 has have VBZ cord-023095-4dannjjm 1303 12 not not RB cord-023095-4dannjjm 1303 13 been be VBN cord-023095-4dannjjm 1303 14 documented document VBN cord-023095-4dannjjm 1303 15 in in IN cord-023095-4dannjjm 1303 16 any any DT cord-023095-4dannjjm 1303 17 species specie NNS cord-023095-4dannjjm 1303 18 thus thus RB cord-023095-4dannjjm 1303 19 far far RB cord-023095-4dannjjm 1303 20 . . . cord-023095-4dannjjm 1304 1 Stall stall JJ cord-023095-4dannjjm 1304 2 - - HYPH cord-023095-4dannjjm 1304 3 side side NN cord-023095-4dannjjm 1304 4 assessment assessment NN cord-023095-4dannjjm 1304 5 of of IN cord-023095-4dannjjm 1304 6 this this DT cord-023095-4dannjjm 1304 7 cardiac cardiac JJ cord-023095-4dannjjm 1304 8 biomarker biomarker NN cord-023095-4dannjjm 1304 9 in in IN cord-023095-4dannjjm 1304 10 horses horse NNS cord-023095-4dannjjm 1304 11 should should MD cord-023095-4dannjjm 1304 12 enhance enhance VB cord-023095-4dannjjm 1304 13 the the DT cord-023095-4dannjjm 1304 14 ability ability NN cord-023095-4dannjjm 1304 15 of of IN cord-023095-4dannjjm 1304 16 clinicians clinician NNS cord-023095-4dannjjm 1304 17 to to TO cord-023095-4dannjjm 1304 18 detect detect VB cord-023095-4dannjjm 1304 19 myocardial myocardial JJ cord-023095-4dannjjm 1304 20 damage damage NN cord-023095-4dannjjm 1304 21 and and CC cord-023095-4dannjjm 1304 22 aid aid NN cord-023095-4dannjjm 1304 23 in in IN cord-023095-4dannjjm 1304 24 the the DT cord-023095-4dannjjm 1304 25 management management NN cord-023095-4dannjjm 1304 26 and and CC cord-023095-4dannjjm 1304 27 treatment treatment NN cord-023095-4dannjjm 1304 28 of of IN cord-023095-4dannjjm 1304 29 horses horse NNS cord-023095-4dannjjm 1304 30 with with IN cord-023095-4dannjjm 1304 31 cardiac cardiac JJ cord-023095-4dannjjm 1304 32 disease disease NN cord-023095-4dannjjm 1304 33 . . . cord-023095-4dannjjm 1305 1 The the DT cord-023095-4dannjjm 1305 2 objective objective NN cord-023095-4dannjjm 1305 3 of of IN cord-023095-4dannjjm 1305 4 the the DT cord-023095-4dannjjm 1305 5 study study NN cord-023095-4dannjjm 1305 6 was be VBD cord-023095-4dannjjm 1305 7 to to TO cord-023095-4dannjjm 1305 8 evaluate evaluate VB cord-023095-4dannjjm 1305 9 the the DT cord-023095-4dannjjm 1305 10 between between IN cord-023095-4dannjjm 1305 11 - - HYPH cord-023095-4dannjjm 1305 12 pony pony NN cord-023095-4dannjjm 1305 13 , , , cord-023095-4dannjjm 1305 14 within within IN cord-023095-4dannjjm 1305 15 - - HYPH cord-023095-4dannjjm 1305 16 pony pony NN cord-023095-4dannjjm 1305 17 , , , cord-023095-4dannjjm 1305 18 between between IN cord-023095-4dannjjm 1305 19 - - HYPH cord-023095-4dannjjm 1305 20 analyser analyser NN cord-023095-4dannjjm 1305 21 and and CC cord-023095-4dannjjm 1305 22 within within IN cord-023095-4dannjjm 1305 23 - - HYPH cord-023095-4dannjjm 1305 24 analyser analyser NN cord-023095-4dannjjm 1305 25 variation variation NN cord-023095-4dannjjm 1305 26 of of IN cord-023095-4dannjjm 1305 27 flow flow NN cord-023095-4dannjjm 1305 28 - - HYPH cord-023095-4dannjjm 1305 29 mediated mediate VBN cord-023095-4dannjjm 1305 30 vasodilation vasodilation NN cord-023095-4dannjjm 1305 31 ( ( -LRB- cord-023095-4dannjjm 1305 32 FMD FMD NNP cord-023095-4dannjjm 1305 33 ) ) -RRB- cord-023095-4dannjjm 1305 34 measurement measurement NN cord-023095-4dannjjm 1305 35 in in IN cord-023095-4dannjjm 1305 36 healthy healthy JJ cord-023095-4dannjjm 1305 37 ponies pony NNS cord-023095-4dannjjm 1305 38 , , , cord-023095-4dannjjm 1305 39 to to TO cord-023095-4dannjjm 1305 40 investigate investigate VB cord-023095-4dannjjm 1305 41 the the DT cord-023095-4dannjjm 1305 42 hypothesis hypothesis NN cord-023095-4dannjjm 1305 43 that that IN cord-023095-4dannjjm 1305 44 FMD FMD NNP cord-023095-4dannjjm 1305 45 occurs occur VBZ cord-023095-4dannjjm 1305 46 in in IN cord-023095-4dannjjm 1305 47 healthy healthy JJ cord-023095-4dannjjm 1305 48 ponies pony NNS cord-023095-4dannjjm 1305 49 . . . cord-023095-4dannjjm 1306 1 Six six CD cord-023095-4dannjjm 1306 2 healthy healthy JJ cord-023095-4dannjjm 1306 3 , , , cord-023095-4dannjjm 1306 4 native native JJ cord-023095-4dannjjm 1306 5 breed breed NN cord-023095-4dannjjm 1306 6 , , , cord-023095-4dannjjm 1306 7 unrelated unrelated JJ cord-023095-4dannjjm 1306 8 pony pony NN cord-023095-4dannjjm 1306 9 mares mare NNS cord-023095-4dannjjm 1306 10 of of IN cord-023095-4dannjjm 1306 11 varying vary VBG cord-023095-4dannjjm 1306 12 weight weight NN cord-023095-4dannjjm 1306 13 ( ( -LRB- cord-023095-4dannjjm 1306 14 236 236 CD cord-023095-4dannjjm 1306 15 - - SYM cord-023095-4dannjjm 1306 16 406 406 CD cord-023095-4dannjjm 1306 17 kg kg NNP cord-023095-4dannjjm 1306 18 ) ) -RRB- cord-023095-4dannjjm 1306 19 , , , cord-023095-4dannjjm 1306 20 body body NN cord-023095-4dannjjm 1306 21 condition condition NN cord-023095-4dannjjm 1306 22 score score NN cord-023095-4dannjjm 1306 23 ( ( -LRB- cord-023095-4dannjjm 1306 24 3/9 3/9 CD cord-023095-4dannjjm 1306 25 - - SYM cord-023095-4dannjjm 1306 26 7/9 7/9 CD cord-023095-4dannjjm 1306 27 ) ) -RRB- cord-023095-4dannjjm 1306 28 and and CC cord-023095-4dannjjm 1306 29 age age NN cord-023095-4dannjjm 1306 30 ( ( -LRB- cord-023095-4dannjjm 1306 31 14 14 CD cord-023095-4dannjjm 1306 32 - - SYM cord-023095-4dannjjm 1306 33 25 25 CD cord-023095-4dannjjm 1306 34 years year NNS cord-023095-4dannjjm 1306 35 ) ) -RRB- cord-023095-4dannjjm 1306 36 were be VBD cord-023095-4dannjjm 1306 37 used use VBN cord-023095-4dannjjm 1306 38 . . . cord-023095-4dannjjm 1307 1 The the DT cord-023095-4dannjjm 1307 2 median median JJ cord-023095-4dannjjm 1307 3 artery artery NN cord-023095-4dannjjm 1307 4 was be VBD cord-023095-4dannjjm 1307 5 occluded occlude VBN cord-023095-4dannjjm 1307 6 for for IN cord-023095-4dannjjm 1307 7 5 5 CD cord-023095-4dannjjm 1307 8 minutes minute NNS cord-023095-4dannjjm 1307 9 . . . cord-023095-4dannjjm 1308 1 Twodimensional Twodimensional NNP cord-023095-4dannjjm 1308 2 ( ( -LRB- cord-023095-4dannjjm 1308 3 2D 2D NNP cord-023095-4dannjjm 1308 4 ) ) -RRB- cord-023095-4dannjjm 1308 5 ultrasonographic ultrasonographic JJ cord-023095-4dannjjm 1308 6 images image NNS cord-023095-4dannjjm 1308 7 of of IN cord-023095-4dannjjm 1308 8 the the DT cord-023095-4dannjjm 1308 9 artery artery NN cord-023095-4dannjjm 1308 10 were be VBD cord-023095-4dannjjm 1308 11 recorded record VBN cord-023095-4dannjjm 1308 12 for for IN cord-023095-4dannjjm 1308 13 30 30 CD cord-023095-4dannjjm 1308 14 seconds second NNS cord-023095-4dannjjm 1308 15 prior prior RB cord-023095-4dannjjm 1308 16 to to IN cord-023095-4dannjjm 1308 17 and and CC cord-023095-4dannjjm 1308 18 for for IN cord-023095-4dannjjm 1308 19 2 2 CD cord-023095-4dannjjm 1308 20 minutes minute NNS cord-023095-4dannjjm 1308 21 after after IN cord-023095-4dannjjm 1308 22 occlusion occlusion NN cord-023095-4dannjjm 1308 23 . . . cord-023095-4dannjjm 1309 1 The the DT cord-023095-4dannjjm 1309 2 peak peak NN cord-023095-4dannjjm 1309 3 luminal luminal JJ cord-023095-4dannjjm 1309 4 diameter diameter NN cord-023095-4dannjjm 1309 5 was be VBD cord-023095-4dannjjm 1309 6 compared compare VBN cord-023095-4dannjjm 1309 7 to to IN cord-023095-4dannjjm 1309 8 baseline baseline JJ cord-023095-4dannjjm 1309 9 diameter diameter NN cord-023095-4dannjjm 1309 10 to to TO cord-023095-4dannjjm 1309 11 calculate calculate VB cord-023095-4dannjjm 1309 12 the the DT cord-023095-4dannjjm 1309 13 relative relative JJ cord-023095-4dannjjm 1309 14 percentage percentage NN cord-023095-4dannjjm 1309 15 increase increase NN cord-023095-4dannjjm 1309 16 in in IN cord-023095-4dannjjm 1309 17 luminal luminal JJ cord-023095-4dannjjm 1309 18 size size NN cord-023095-4dannjjm 1309 19 ( ( -LRB- cord-023095-4dannjjm 1309 20 FMD FMD NNP cord-023095-4dannjjm 1309 21 ) ) -RRB- cord-023095-4dannjjm 1309 22 . . . cord-023095-4dannjjm 1310 1 Images image NNS cord-023095-4dannjjm 1310 2 were be VBD cord-023095-4dannjjm 1310 3 obtained obtain VBN cord-023095-4dannjjm 1310 4 from from IN cord-023095-4dannjjm 1310 5 six six CD cord-023095-4dannjjm 1310 6 ponies pony NNS cord-023095-4dannjjm 1310 7 on on IN cord-023095-4dannjjm 1310 8 one one CD cord-023095-4dannjjm 1310 9 occasion occasion NN cord-023095-4dannjjm 1310 10 and and CC cord-023095-4dannjjm 1310 11 from from IN cord-023095-4dannjjm 1310 12 one one CD cord-023095-4dannjjm 1310 13 pony pony NN cord-023095-4dannjjm 1310 14 on on IN cord-023095-4dannjjm 1310 15 six six CD cord-023095-4dannjjm 1310 16 occasions occasion NNS cord-023095-4dannjjm 1310 17 . . . cord-023095-4dannjjm 1311 1 Analysis analysis NN cord-023095-4dannjjm 1311 2 of of IN cord-023095-4dannjjm 1311 3 images image NNS cord-023095-4dannjjm 1311 4 was be VBD cord-023095-4dannjjm 1311 5 performed perform VBN cord-023095-4dannjjm 1311 6 by by IN cord-023095-4dannjjm 1311 7 two two CD cord-023095-4dannjjm 1311 8 independent independent JJ cord-023095-4dannjjm 1311 9 analysers analyser NNS cord-023095-4dannjjm 1311 10 and and CC cord-023095-4dannjjm 1311 11 by by IN cord-023095-4dannjjm 1311 12 one one CD cord-023095-4dannjjm 1311 13 analyser analyser NN cord-023095-4dannjjm 1311 14 twice twice RB cord-023095-4dannjjm 1311 15 . . . cord-023095-4dannjjm 1312 1 The the DT cord-023095-4dannjjm 1312 2 mean mean JJ cord-023095-4dannjjm 1312 3 ( ( -LRB- cord-023095-4dannjjm 1312 4 SD sd NN cord-023095-4dannjjm 1312 5 ) ) -RRB- cord-023095-4dannjjm 1312 6 FMD FMD NNP cord-023095-4dannjjm 1312 7 in in IN cord-023095-4dannjjm 1312 8 6 6 CD cord-023095-4dannjjm 1312 9 ponies pony NNS cord-023095-4dannjjm 1312 10 was be VBD cord-023095-4dannjjm 1312 11 12.57 12.57 CD cord-023095-4dannjjm 1312 12 % % NN cord-023095-4dannjjm 1312 13 ( ( -LRB- cord-023095-4dannjjm 1312 14 4.28 4.28 CD cord-023095-4dannjjm 1312 15 % % NN cord-023095-4dannjjm 1312 16 ) ) -RRB- cord-023095-4dannjjm 1312 17 and and CC cord-023095-4dannjjm 1312 18 in in IN cord-023095-4dannjjm 1312 19 1 1 CD cord-023095-4dannjjm 1312 20 pony pony NN cord-023095-4dannjjm 1312 21 ( ( -LRB- cord-023095-4dannjjm 1312 22 6 6 CD cord-023095-4dannjjm 1312 23 occasions occasion NNS cord-023095-4dannjjm 1312 24 ) ) -RRB- cord-023095-4dannjjm 1312 25 was be VBD cord-023095-4dannjjm 1312 26 7.30 7.30 CD cord-023095-4dannjjm 1312 27 % % NN cord-023095-4dannjjm 1312 28 ( ( -LRB- cord-023095-4dannjjm 1312 29 2.11 2.11 CD cord-023095-4dannjjm 1312 30 % % NN cord-023095-4dannjjm 1312 31 ) ) -RRB- cord-023095-4dannjjm 1312 32 . . . cord-023095-4dannjjm 1313 1 Coefficients coefficient NNS cord-023095-4dannjjm 1313 2 of of IN cord-023095-4dannjjm 1313 3 variation variation NN cord-023095-4dannjjm 1313 4 were be VBD cord-023095-4dannjjm 1313 5 34.09 34.09 CD cord-023095-4dannjjm 1313 6 % % NN cord-023095-4dannjjm 1313 7 and and CC cord-023095-4dannjjm 1313 8 28.84 28.84 CD cord-023095-4dannjjm 1313 9 % % NN cord-023095-4dannjjm 1313 10 respectively respectively RB cord-023095-4dannjjm 1313 11 . . . cord-023095-4dannjjm 1314 1 Agreement agreement NN cord-023095-4dannjjm 1314 2 between between IN cord-023095-4dannjjm 1314 3 analysers analyser NNS cord-023095-4dannjjm 1314 4 was be VBD cord-023095-4dannjjm 1314 5 fair fair JJ cord-023095-4dannjjm 1314 6 ( ( -LRB- cord-023095-4dannjjm 1314 7 ICC ICC NNP cord-023095-4dannjjm 1314 8 5 5 CD cord-023095-4dannjjm 1314 9 0.47 0.47 CD cord-023095-4dannjjm 1314 10 ) ) -RRB- cord-023095-4dannjjm 1314 11 and and CC cord-023095-4dannjjm 1314 12 within within IN cord-023095-4dannjjm 1314 13 analyser analyser NN cord-023095-4dannjjm 1314 14 was be VBD cord-023095-4dannjjm 1314 15 poor poor JJ cord-023095-4dannjjm 1314 16 ( ( -LRB- cord-023095-4dannjjm 1314 17 ICC ICC NNP cord-023095-4dannjjm 1314 18 5 5 CD cord-023095-4dannjjm 1314 19 0.30 0.30 CD cord-023095-4dannjjm 1314 20 ) ) -RRB- cord-023095-4dannjjm 1314 21 . . . cord-023095-4dannjjm 1315 1 FMD FMD NNP cord-023095-4dannjjm 1315 2 is be VBZ cord-023095-4dannjjm 1315 3 used use VBN cord-023095-4dannjjm 1315 4 to to TO cord-023095-4dannjjm 1315 5 assess assess VB cord-023095-4dannjjm 1315 6 endothelial endothelial JJ cord-023095-4dannjjm 1315 7 function function NN cord-023095-4dannjjm 1315 8 in in IN cord-023095-4dannjjm 1315 9 humans human NNS cord-023095-4dannjjm 1315 10 and and CC cord-023095-4dannjjm 1315 11 has have VBZ cord-023095-4dannjjm 1315 12 recently recently RB cord-023095-4dannjjm 1315 13 been be VBN cord-023095-4dannjjm 1315 14 assessed assess VBN cord-023095-4dannjjm 1315 15 for for IN cord-023095-4dannjjm 1315 16 its -PRON- PRP$ cord-023095-4dannjjm 1315 17 use use NN cord-023095-4dannjjm 1315 18 in in IN cord-023095-4dannjjm 1315 19 canine canine JJ cord-023095-4dannjjm 1315 20 subjects subject NNS cord-023095-4dannjjm 1315 21 . . . cord-023095-4dannjjm 1316 1 FMD FMD NNP cord-023095-4dannjjm 1316 2 occurs occur VBZ cord-023095-4dannjjm 1316 3 and and CC cord-023095-4dannjjm 1316 4 measurement measurement NN cord-023095-4dannjjm 1316 5 is be VBZ cord-023095-4dannjjm 1316 6 feasible feasible JJ cord-023095-4dannjjm 1316 7 in in IN cord-023095-4dannjjm 1316 8 ponies pony NNS cord-023095-4dannjjm 1316 9 . . . cord-023095-4dannjjm 1317 1 FMD FMD NNP cord-023095-4dannjjm 1317 2 could could MD cord-023095-4dannjjm 1317 3 be be VB cord-023095-4dannjjm 1317 4 used use VBN cord-023095-4dannjjm 1317 5 to to TO cord-023095-4dannjjm 1317 6 assess assess VB cord-023095-4dannjjm 1317 7 endothelial endothelial JJ cord-023095-4dannjjm 1317 8 function function NN cord-023095-4dannjjm 1317 9 , , , cord-023095-4dannjjm 1317 10 in in IN cord-023095-4dannjjm 1317 11 the the DT cord-023095-4dannjjm 1317 12 context context NN cord-023095-4dannjjm 1317 13 of of IN cord-023095-4dannjjm 1317 14 laminitis laminitis NN cord-023095-4dannjjm 1317 15 or or CC cord-023095-4dannjjm 1317 16 other other JJ cord-023095-4dannjjm 1317 17 cardiovascular cardiovascular JJ cord-023095-4dannjjm 1317 18 diseases disease NNS cord-023095-4dannjjm 1317 19 . . . cord-023095-4dannjjm 1318 1 Current current JJ cord-023095-4dannjjm 1318 2 state state NN cord-023095-4dannjjm 1318 3 - - HYPH cord-023095-4dannjjm 1318 4 of of IN cord-023095-4dannjjm 1318 5 - - HYPH cord-023095-4dannjjm 1318 6 the the DT cord-023095-4dannjjm 1318 7 - - HYPH cord-023095-4dannjjm 1318 8 art art NN cord-023095-4dannjjm 1318 9 technique technique NN cord-023095-4dannjjm 1318 10 for for IN cord-023095-4dannjjm 1318 11 measuring measure VBG cord-023095-4dannjjm 1318 12 blood blood NN cord-023095-4dannjjm 1318 13 pressure pressure NN cord-023095-4dannjjm 1318 14 ( ( -LRB- cord-023095-4dannjjm 1318 15 BP BP NNP cord-023095-4dannjjm 1318 16 ) ) -RRB- cord-023095-4dannjjm 1318 17 in in IN cord-023095-4dannjjm 1318 18 the the DT cord-023095-4dannjjm 1318 19 horse horse NN cord-023095-4dannjjm 1318 20 is be VBZ cord-023095-4dannjjm 1318 21 invasive invasive JJ cord-023095-4dannjjm 1318 22 and and CC cord-023095-4dannjjm 1318 23 involves involve VBZ cord-023095-4dannjjm 1318 24 cannulation cannulation NN cord-023095-4dannjjm 1318 25 of of IN cord-023095-4dannjjm 1318 26 the the DT cord-023095-4dannjjm 1318 27 facial facial JJ cord-023095-4dannjjm 1318 28 artery artery NN cord-023095-4dannjjm 1318 29 . . . cord-023095-4dannjjm 1319 1 Indirect indirect JJ cord-023095-4dannjjm 1319 2 techniques technique NNS cord-023095-4dannjjm 1319 3 , , , cord-023095-4dannjjm 1319 4 such such JJ cord-023095-4dannjjm 1319 5 as as IN cord-023095-4dannjjm 1319 6 oscillometry oscillometry NNP cord-023095-4dannjjm 1319 7 , , , cord-023095-4dannjjm 1319 8 have have VBP cord-023095-4dannjjm 1319 9 proven prove VBN cord-023095-4dannjjm 1319 10 useful useful JJ cord-023095-4dannjjm 1319 11 in in IN cord-023095-4dannjjm 1319 12 the the DT cord-023095-4dannjjm 1319 13 anaesthetised anaesthetised JJ cord-023095-4dannjjm 1319 14 horse horse NN cord-023095-4dannjjm 1319 15 , , , cord-023095-4dannjjm 1319 16 but but CC cord-023095-4dannjjm 1319 17 have have VBP cord-023095-4dannjjm 1319 18 not not RB cord-023095-4dannjjm 1319 19 become become VBN cord-023095-4dannjjm 1319 20 routine routine JJ cord-023095-4dannjjm 1319 21 in in IN cord-023095-4dannjjm 1319 22 the the DT cord-023095-4dannjjm 1319 23 standing standing JJ cord-023095-4dannjjm 1319 24 horse horse NN cord-023095-4dannjjm 1319 25 . . . cord-023095-4dannjjm 1320 1 Monitoring Monitoring NNP cord-023095-4dannjjm 1320 2 BP BP NNP cord-023095-4dannjjm 1320 3 can can MD cord-023095-4dannjjm 1320 4 be be VB cord-023095-4dannjjm 1320 5 indicated indicate VBN cord-023095-4dannjjm 1320 6 for for IN cord-023095-4dannjjm 1320 7 the the DT cord-023095-4dannjjm 1320 8 diagnosis diagnosis NN cord-023095-4dannjjm 1320 9 and and CC cord-023095-4dannjjm 1320 10 treatment treatment NN cord-023095-4dannjjm 1320 11 of of IN cord-023095-4dannjjm 1320 12 the the DT cord-023095-4dannjjm 1320 13 hypotensive hypotensive JJ cord-023095-4dannjjm 1320 14 patient patient NN cord-023095-4dannjjm 1320 15 ( ( -LRB- cord-023095-4dannjjm 1320 16 ie ie FW cord-023095-4dannjjm 1320 17 . . . cord-023095-4dannjjm 1320 18 caused cause VBN cord-023095-4dannjjm 1320 19 by by IN cord-023095-4dannjjm 1320 20 endotoxemia endotoxemia NN cord-023095-4dannjjm 1320 21 , , , cord-023095-4dannjjm 1320 22 hypovolemia hypovolemia NN cord-023095-4dannjjm 1320 23 , , , cord-023095-4dannjjm 1321 1 Systemic systemic JJ cord-023095-4dannjjm 1321 2 Inflammatory Inflammatory NNP cord-023095-4dannjjm 1321 3 Response Response NNP cord-023095-4dannjjm 1321 4 Syndrome Syndrome NNP cord-023095-4dannjjm 1321 5 and and CC cord-023095-4dannjjm 1321 6 cardiac cardiac JJ cord-023095-4dannjjm 1321 7 failure failure NN cord-023095-4dannjjm 1321 8 ) ) -RRB- cord-023095-4dannjjm 1321 9 or or CC cord-023095-4dannjjm 1321 10 the the DT cord-023095-4dannjjm 1321 11 hypertensive hypertensive JJ cord-023095-4dannjjm 1321 12 patient patient NN cord-023095-4dannjjm 1321 13 ( ( -LRB- cord-023095-4dannjjm 1322 1 ie ie NNP cord-023095-4dannjjm 1322 2 . . . cord-023095-4dannjjm 1323 1 due due IN cord-023095-4dannjjm 1323 2 to to IN cord-023095-4dannjjm 1323 3 equine equine JJ cord-023095-4dannjjm 1323 4 metabolic metabolic JJ cord-023095-4dannjjm 1323 5 syndrome syndrome NN cord-023095-4dannjjm 1323 6 or or CC cord-023095-4dannjjm 1323 7 pain pain NN cord-023095-4dannjjm 1323 8 ) ) -RRB- cord-023095-4dannjjm 1323 9 . . . cord-023095-4dannjjm 1324 1 The the DT cord-023095-4dannjjm 1324 2 objective objective NN cord-023095-4dannjjm 1324 3 of of IN cord-023095-4dannjjm 1324 4 this this DT cord-023095-4dannjjm 1324 5 study study NN cord-023095-4dannjjm 1324 6 was be VBD cord-023095-4dannjjm 1324 7 therefore therefore RB cord-023095-4dannjjm 1324 8 to to IN cord-023095-4dannjjm 1324 9 a a DT cord-023095-4dannjjm 1324 10 ) ) -RRB- cord-023095-4dannjjm 1324 11 describe describe VB cord-023095-4dannjjm 1324 12 the the DT cord-023095-4dannjjm 1324 13 methodology methodology NN cord-023095-4dannjjm 1324 14 for for IN cord-023095-4dannjjm 1324 15 application application NN cord-023095-4dannjjm 1324 16 of of IN cord-023095-4dannjjm 1324 17 oscillometric oscillometric NNP cord-023095-4dannjjm 1324 18 BP BP NNP cord-023095-4dannjjm 1324 19 using use VBG cord-023095-4dannjjm 1324 20 a a DT cord-023095-4dannjjm 1324 21 cuff cuff NN cord-023095-4dannjjm 1324 22 applied apply VBN cord-023095-4dannjjm 1324 23 to to IN cord-023095-4dannjjm 1324 24 the the DT cord-023095-4dannjjm 1324 25 tail tail NN cord-023095-4dannjjm 1324 26 in in IN cord-023095-4dannjjm 1324 27 the the DT cord-023095-4dannjjm 1324 28 standing standing NN cord-023095-4dannjjm 1324 29 horse horse NN cord-023095-4dannjjm 1324 30 and and CC cord-023095-4dannjjm 1324 31 b b LS cord-023095-4dannjjm 1324 32 ) ) -RRB- cord-023095-4dannjjm 1324 33 and and CC cord-023095-4dannjjm 1324 34 to to TO cord-023095-4dannjjm 1324 35 determine determine VB cord-023095-4dannjjm 1324 36 accuracy accuracy NN cord-023095-4dannjjm 1324 37 and and CC cord-023095-4dannjjm 1324 38 precision precision NN cord-023095-4dannjjm 1324 39 of of IN cord-023095-4dannjjm 1324 40 this this DT cord-023095-4dannjjm 1324 41 method method NN cord-023095-4dannjjm 1324 42 applied apply VBN cord-023095-4dannjjm 1324 43 to to IN cord-023095-4dannjjm 1324 44 the the DT cord-023095-4dannjjm 1324 45 normotensive normotensive JJ cord-023095-4dannjjm 1324 46 standing standing NNP cord-023095-4dannjjm 1324 47 horse horse NN cord-023095-4dannjjm 1324 48 . . . cord-023095-4dannjjm 1325 1 The the DT cord-023095-4dannjjm 1325 2 oscillometric oscillometric JJ cord-023095-4dannjjm 1325 3 method method NN cord-023095-4dannjjm 1325 4 is be VBZ cord-023095-4dannjjm 1325 5 simple simple JJ cord-023095-4dannjjm 1325 6 to to TO cord-023095-4dannjjm 1325 7 apply apply VB cord-023095-4dannjjm 1325 8 in in IN cord-023095-4dannjjm 1325 9 a a DT cord-023095-4dannjjm 1325 10 clinical clinical JJ cord-023095-4dannjjm 1325 11 setting setting NN cord-023095-4dannjjm 1325 12 . . . cord-023095-4dannjjm 1326 1 A a DT cord-023095-4dannjjm 1326 2 pneumatic pneumatic JJ cord-023095-4dannjjm 1326 3 cuff cuff NN cord-023095-4dannjjm 1326 4 is be VBZ cord-023095-4dannjjm 1326 5 snugly snugly RB cord-023095-4dannjjm 1326 6 applied apply VBN cord-023095-4dannjjm 1326 7 to to IN cord-023095-4dannjjm 1326 8 the the DT cord-023095-4dannjjm 1326 9 unclipped unclipped JJ cord-023095-4dannjjm 1326 10 tail tail NN cord-023095-4dannjjm 1326 11 - - HYPH cord-023095-4dannjjm 1326 12 base base NN cord-023095-4dannjjm 1326 13 with with IN cord-023095-4dannjjm 1326 14 the the DT cord-023095-4dannjjm 1326 15 cuff cuff NN cord-023095-4dannjjm 1326 16 bladder bladder NN cord-023095-4dannjjm 1326 17 centered center VBN cord-023095-4dannjjm 1326 18 over over IN cord-023095-4dannjjm 1326 19 the the DT cord-023095-4dannjjm 1326 20 middle middle JJ cord-023095-4dannjjm 1326 21 coccygeal coccygeal NN cord-023095-4dannjjm 1326 22 artery artery NN cord-023095-4dannjjm 1326 23 . . . cord-023095-4dannjjm 1327 1 The the DT cord-023095-4dannjjm 1327 2 tail tail NN cord-023095-4dannjjm 1327 3 circumference circumference NN cord-023095-4dannjjm 1327 4 must must MD cord-023095-4dannjjm 1327 5 match match VB cord-023095-4dannjjm 1327 6 the the DT cord-023095-4dannjjm 1327 7 manufacturers manufacturer NNS cord-023095-4dannjjm 1327 8 description description NN cord-023095-4dannjjm 1327 9 of of IN cord-023095-4dannjjm 1327 10 the the DT cord-023095-4dannjjm 1327 11 cuffs cuff NNS cord-023095-4dannjjm 1327 12 diameter diameter NN cord-023095-4dannjjm 1327 13 range range NN cord-023095-4dannjjm 1327 14 . . . cord-023095-4dannjjm 1328 1 The the DT cord-023095-4dannjjm 1328 2 oscillometric oscillometric NN cord-023095-4dannjjm 1328 3 apparatus apparatus NN cord-023095-4dannjjm 1328 4 inflates inflate VBZ cord-023095-4dannjjm 1328 5 the the DT cord-023095-4dannjjm 1328 6 cuff cuff NN cord-023095-4dannjjm 1328 7 and and CC cord-023095-4dannjjm 1328 8 obtain obtain VB cord-023095-4dannjjm 1328 9 systolic systolic JJ cord-023095-4dannjjm 1328 10 , , , cord-023095-4dannjjm 1328 11 diastolic diastolic JJ cord-023095-4dannjjm 1328 12 and and CC cord-023095-4dannjjm 1328 13 mean mean VBP cord-023095-4dannjjm 1328 14 arterial arterial JJ cord-023095-4dannjjm 1328 15 BP BP NNP cord-023095-4dannjjm 1328 16 ( ( -LRB- cord-023095-4dannjjm 1328 17 SAP SAP NNP cord-023095-4dannjjm 1328 18 , , , cord-023095-4dannjjm 1328 19 DAP DAP NNP cord-023095-4dannjjm 1328 20 and and CC cord-023095-4dannjjm 1328 21 MAP MAP NNP cord-023095-4dannjjm 1328 22 ) ) -RRB- cord-023095-4dannjjm 1328 23 . . . cord-023095-4dannjjm 1329 1 At at RB cord-023095-4dannjjm 1329 2 least least JJS cord-023095-4dannjjm 1329 3 2 2 CD cord-023095-4dannjjm 1329 4 consecutive consecutive JJ cord-023095-4dannjjm 1329 5 measurements measurement NNS cord-023095-4dannjjm 1329 6 must must MD cord-023095-4dannjjm 1329 7 be be VB cord-023095-4dannjjm 1329 8 obtained obtain VBN cord-023095-4dannjjm 1329 9 . . . cord-023095-4dannjjm 1330 1 A a DT cord-023095-4dannjjm 1330 2 correction correction NN cord-023095-4dannjjm 1330 3 of of IN cord-023095-4dannjjm 1330 4 0.7 0.7 CD cord-023095-4dannjjm 1330 5 mmHg mmHg NNS cord-023095-4dannjjm 1330 6 / / SYM cord-023095-4dannjjm 1330 7 cm cm NN cord-023095-4dannjjm 1330 8 vertical vertical JJ cord-023095-4dannjjm 1330 9 distance distance NN cord-023095-4dannjjm 1330 10 between between IN cord-023095-4dannjjm 1330 11 cuff cuff NN cord-023095-4dannjjm 1330 12 and and CC cord-023095-4dannjjm 1330 13 heart heart NN cord-023095-4dannjjm 1330 14 level level NN cord-023095-4dannjjm 1330 15 is be VBZ cord-023095-4dannjjm 1330 16 added add VBN cord-023095-4dannjjm 1330 17 to to IN cord-023095-4dannjjm 1330 18 the the DT cord-023095-4dannjjm 1330 19 measurement measurement NN cord-023095-4dannjjm 1330 20 to to TO cord-023095-4dannjjm 1330 21 correct correct VB cord-023095-4dannjjm 1330 22 for for IN cord-023095-4dannjjm 1330 23 hydrostatic hydrostatic JJ cord-023095-4dannjjm 1330 24 pressure pressure NN cord-023095-4dannjjm 1330 25 difference difference NN cord-023095-4dannjjm 1330 26 . . . cord-023095-4dannjjm 1331 1 For for IN cord-023095-4dannjjm 1331 2 determination determination NN cord-023095-4dannjjm 1331 3 of of IN cord-023095-4dannjjm 1331 4 accuracy accuracy NN cord-023095-4dannjjm 1331 5 and and CC cord-023095-4dannjjm 1331 6 precision precision NN cord-023095-4dannjjm 1331 7 of of IN cord-023095-4dannjjm 1331 8 indirect indirect JJ cord-023095-4dannjjm 1331 9 SAP SAP NNP cord-023095-4dannjjm 1331 10 , , , cord-023095-4dannjjm 1331 11 DAP DAP NNP cord-023095-4dannjjm 1331 12 and and CC cord-023095-4dannjjm 1331 13 MAP MAP NNP cord-023095-4dannjjm 1331 14 , , , cord-023095-4dannjjm 1331 15 eight eight CD cord-023095-4dannjjm 1331 16 healthy healthy JJ cord-023095-4dannjjm 1331 17 horses horse NNS cord-023095-4dannjjm 1331 18 ( ( -LRB- cord-023095-4dannjjm 1331 19 age age NN cord-023095-4dannjjm 1331 20 3 3 CD cord-023095-4dannjjm 1331 21 to to TO cord-023095-4dannjjm 1331 22 16 16 CD cord-023095-4dannjjm 1331 23 years year NNS cord-023095-4dannjjm 1331 24 ) ) -RRB- cord-023095-4dannjjm 1331 25 , , , cord-023095-4dannjjm 1331 26 was be VBD cord-023095-4dannjjm 1331 27 equipped equip VBN cord-023095-4dannjjm 1331 28 with with IN cord-023095-4dannjjm 1331 29 an an DT cord-023095-4dannjjm 1331 30 intra intra JJ cord-023095-4dannjjm 1331 31 - - JJ cord-023095-4dannjjm 1331 32 arterial arterial JJ cord-023095-4dannjjm 1331 33 catheter catheter NN cord-023095-4dannjjm 1331 34 ii ii NN cord-023095-4dannjjm 1331 35 in in IN cord-023095-4dannjjm 1331 36 the the DT cord-023095-4dannjjm 1331 37 facial facial JJ cord-023095-4dannjjm 1331 38 artery artery NN cord-023095-4dannjjm 1331 39 and and CC cord-023095-4dannjjm 1331 40 a a DT cord-023095-4dannjjm 1331 41 commercial commercial JJ cord-023095-4dannjjm 1331 42 tail tail NN cord-023095-4dannjjm 1331 43 - - HYPH cord-023095-4dannjjm 1331 44 cuff cuff NN cord-023095-4dannjjm 1331 45 oscillometric oscillometric NN cord-023095-4dannjjm 1331 46 apparatus apparatus NN cord-023095-4dannjjm 1331 47 . . . cord-023095-4dannjjm 1332 1 i i PRP cord-023095-4dannjjm 1332 2 Measurements Measurements NNPS cord-023095-4dannjjm 1332 3 were be VBD cord-023095-4dannjjm 1332 4 recorded record VBN cord-023095-4dannjjm 1332 5 every every DT cord-023095-4dannjjm 1332 6 2 2 CD cord-023095-4dannjjm 1332 7 minutes minute NNS cord-023095-4dannjjm 1332 8 for for IN cord-023095-4dannjjm 1332 9 20 20 CD cord-023095-4dannjjm 1332 10 minutes minute NNS cord-023095-4dannjjm 1332 11 . . . cord-023095-4dannjjm 1333 1 The the DT cord-023095-4dannjjm 1333 2 data datum NNS cord-023095-4dannjjm 1333 3 were be VBD cord-023095-4dannjjm 1333 4 analysed analyse VBN cord-023095-4dannjjm 1333 5 with with IN cord-023095-4dannjjm 1333 6 the the DT cord-023095-4dannjjm 1333 7 statistical statistical JJ cord-023095-4dannjjm 1333 8 software software NN cord-023095-4dannjjm 1333 9 R r NN cord-023095-4dannjjm 1333 10 using use VBG cord-023095-4dannjjm 1333 11 a a DT cord-023095-4dannjjm 1333 12 mixed mixed JJ cord-023095-4dannjjm 1333 13 model model NN cord-023095-4dannjjm 1333 14 with with IN cord-023095-4dannjjm 1333 15 repeated repeat VBN cord-023095-4dannjjm 1333 16 measurements measurement NNS cord-023095-4dannjjm 1333 17 and and CC cord-023095-4dannjjm 1333 18 a a DT cord-023095-4dannjjm 1333 19 Bland Bland NNP cord-023095-4dannjjm 1333 20 - - HYPH cord-023095-4dannjjm 1333 21 Altman Altman NNP cord-023095-4dannjjm 1333 22 analysis analysis NN cord-023095-4dannjjm 1333 23 corrected correct VBD cord-023095-4dannjjm 1333 24 for for IN cord-023095-4dannjjm 1333 25 repeated repeat VBN cord-023095-4dannjjm 1333 26 measurements measurement NNS cord-023095-4dannjjm 1333 27 . . . cord-023095-4dannjjm 1334 1 Oscillometric Oscillometric NNP cord-023095-4dannjjm 1334 2 BP BP NNP cord-023095-4dannjjm 1334 3 was be VBD cord-023095-4dannjjm 1334 4 accurate accurate JJ cord-023095-4dannjjm 1334 5 and and CC cord-023095-4dannjjm 1334 6 precise precise JJ cord-023095-4dannjjm 1334 7 for for IN cord-023095-4dannjjm 1334 8 MAP MAP NNP cord-023095-4dannjjm 1334 9 ( ( -LRB- cord-023095-4dannjjm 1334 10 mean mean VB cord-023095-4dannjjm 1334 11 bias bias NN cord-023095-4dannjjm 1334 12 , , , cord-023095-4dannjjm 1334 13 lower lower VB cord-023095-4dannjjm 1334 14 confidence confidence NN cord-023095-4dannjjm 1334 15 level level NN cord-023095-4dannjjm 1334 16 , , , cord-023095-4dannjjm 1334 17 upper upper JJ cord-023095-4dannjjm 1334 18 confidence confidence NN cord-023095-4dannjjm 1334 19 level level NN cord-023095-4dannjjm 1334 20 , , , cord-023095-4dannjjm 1334 21 variation variation NN cord-023095-4dannjjm 1334 22 in in IN cord-023095-4dannjjm 1334 23 difference difference NN cord-023095-4dannjjm 1334 24 , , , cord-023095-4dannjjm 1334 25 all all DT cord-023095-4dannjjm 1334 26 mmHg mmHg NNS cord-023095-4dannjjm 1334 27 ) ) -RRB- cord-023095-4dannjjm 1334 28 ( ( -LRB- cord-023095-4dannjjm 1334 29 À0.3 À0.3 NNP cord-023095-4dannjjm 1334 30 , , , cord-023095-4dannjjm 1334 31 À18.5 à18.5 CD cord-023095-4dannjjm 1334 32 , , , cord-023095-4dannjjm 1334 33 19.1 19.1 CD cord-023095-4dannjjm 1334 34 , , , cord-023095-4dannjjm 1334 35 33.2 33.2 CD cord-023095-4dannjjm 1334 36 , , , cord-023095-4dannjjm 1334 37 respectively respectively RB cord-023095-4dannjjm 1334 38 ) ) -RRB- cord-023095-4dannjjm 1334 39 in in IN cord-023095-4dannjjm 1334 40 the the DT cord-023095-4dannjjm 1334 41 conscious conscious JJ cord-023095-4dannjjm 1334 42 horse horse NN cord-023095-4dannjjm 1334 43 but but CC cord-023095-4dannjjm 1334 44 not not RB cord-023095-4dannjjm 1334 45 for for IN cord-023095-4dannjjm 1334 46 SAP SAP NNP cord-023095-4dannjjm 1334 47 ( ( -LRB- cord-023095-4dannjjm 1334 48 À1.5 À1.5 NNS cord-023095-4dannjjm 1334 49 , , , cord-023095-4dannjjm 1334 50 À19.3 à19.3 CD cord-023095-4dannjjm 1334 51 , , , cord-023095-4dannjjm 1334 52 16.3 16.3 CD cord-023095-4dannjjm 1334 53 , , , cord-023095-4dannjjm 1334 54 38.2 38.2 CD cord-023095-4dannjjm 1334 55 , , , cord-023095-4dannjjm 1334 56 respectively respectively RB cord-023095-4dannjjm 1334 57 ) ) -RRB- cord-023095-4dannjjm 1334 58 and and CC cord-023095-4dannjjm 1334 59 DAP DAP NNP cord-023095-4dannjjm 1334 60 ( ( -LRB- cord-023095-4dannjjm 1334 61 0.05 0.05 CD cord-023095-4dannjjm 1334 62 , , , cord-023095-4dannjjm 1334 63 15.9 15.9 CD cord-023095-4dannjjm 1334 64 , , , cord-023095-4dannjjm 1334 65 16.0 16.0 CD cord-023095-4dannjjm 1334 66 , , , cord-023095-4dannjjm 1334 67 49 49 CD cord-023095-4dannjjm 1334 68 , , , cord-023095-4dannjjm 1334 69 respectively respectively RB cord-023095-4dannjjm 1334 70 ) ) -RRB- cord-023095-4dannjjm 1334 71 . . . cord-023095-4dannjjm 1335 1 There there EX cord-023095-4dannjjm 1335 2 was be VBD cord-023095-4dannjjm 1335 3 no no DT cord-023095-4dannjjm 1335 4 significant significant JJ cord-023095-4dannjjm 1335 5 contribution contribution NN cord-023095-4dannjjm 1335 6 to to IN cord-023095-4dannjjm 1335 7 the the DT cord-023095-4dannjjm 1335 8 statistical statistical JJ cord-023095-4dannjjm 1335 9 model model NN cord-023095-4dannjjm 1335 10 of of IN cord-023095-4dannjjm 1335 11 either either DT cord-023095-4dannjjm 1335 12 horse horse NN cord-023095-4dannjjm 1335 13 or or CC cord-023095-4dannjjm 1335 14 measurement measurement NN cord-023095-4dannjjm 1335 15 number number NN cord-023095-4dannjjm 1335 16 . . . cord-023095-4dannjjm 1336 1 All all DT cord-023095-4dannjjm 1336 2 horses horse NNS cord-023095-4dannjjm 1336 3 tolerated tolerate VBD cord-023095-4dannjjm 1336 4 the the DT cord-023095-4dannjjm 1336 5 tail tail NN cord-023095-4dannjjm 1336 6 - - HYPH cord-023095-4dannjjm 1336 7 cuff cuff NN cord-023095-4dannjjm 1336 8 well well NN cord-023095-4dannjjm 1336 9 and and CC cord-023095-4dannjjm 1336 10 the the DT cord-023095-4dannjjm 1336 11 method method NN cord-023095-4dannjjm 1336 12 was be VBD cord-023095-4dannjjm 1336 13 simple simple JJ cord-023095-4dannjjm 1336 14 to to TO cord-023095-4dannjjm 1336 15 apply apply VB cord-023095-4dannjjm 1336 16 . . . cord-023095-4dannjjm 1337 1 Only only RB cord-023095-4dannjjm 1337 2 MAP MAP NNP cord-023095-4dannjjm 1337 3 could could MD cord-023095-4dannjjm 1337 4 be be VB cord-023095-4dannjjm 1337 5 measured measure VBN cord-023095-4dannjjm 1337 6 with with IN cord-023095-4dannjjm 1337 7 acceptable acceptable JJ cord-023095-4dannjjm 1337 8 accuracy accuracy NN cord-023095-4dannjjm 1337 9 and and CC cord-023095-4dannjjm 1337 10 precision precision NN cord-023095-4dannjjm 1337 11 in in IN cord-023095-4dannjjm 1337 12 the the DT cord-023095-4dannjjm 1337 13 normotensive normotensive JJ cord-023095-4dannjjm 1337 14 standing standing NNP cord-023095-4dannjjm 1337 15 horse horse NN cord-023095-4dannjjm 1337 16 using use VBG cord-023095-4dannjjm 1337 17 the the DT cord-023095-4dannjjm 1337 18 described describe VBN cord-023095-4dannjjm 1337 19 oscillometric oscillometric JJ cord-023095-4dannjjm 1337 20 method method NN cord-023095-4dannjjm 1337 21 . . . cord-023095-4dannjjm 1338 1 Reference reference NN cord-023095-4dannjjm 1338 2 intervals interval NNS cord-023095-4dannjjm 1338 3 for for IN cord-023095-4dannjjm 1338 4 thyroid thyroid NN cord-023095-4dannjjm 1338 5 hormone hormone NN cord-023095-4dannjjm 1338 6 ( ( -LRB- cord-023095-4dannjjm 1338 7 TH TH NNP cord-023095-4dannjjm 1338 8 ) ) -RRB- cord-023095-4dannjjm 1338 9 concentrations concentration NNS cord-023095-4dannjjm 1338 10 have have VBP cord-023095-4dannjjm 1338 11 not not RB cord-023095-4dannjjm 1338 12 been be VBN cord-023095-4dannjjm 1338 13 established establish VBN cord-023095-4dannjjm 1338 14 for for IN cord-023095-4dannjjm 1338 15 donkeys donkey NNS cord-023095-4dannjjm 1338 16 . . . cord-023095-4dannjjm 1339 1 Therefore therefore RB cord-023095-4dannjjm 1339 2 , , , cord-023095-4dannjjm 1339 3 clinicians clinician NNS cord-023095-4dannjjm 1339 4 must must MD cord-023095-4dannjjm 1339 5 use use VB cord-023095-4dannjjm 1339 6 reference reference NN cord-023095-4dannjjm 1339 7 ranges range NNS cord-023095-4dannjjm 1339 8 from from IN cord-023095-4dannjjm 1339 9 horses horse NNS cord-023095-4dannjjm 1339 10 , , , cord-023095-4dannjjm 1339 11 potentially potentially RB cord-023095-4dannjjm 1339 12 leading lead VBG cord-023095-4dannjjm 1339 13 to to IN cord-023095-4dannjjm 1339 14 misdiagnosis misdiagnosis NN cord-023095-4dannjjm 1339 15 of of IN cord-023095-4dannjjm 1339 16 thyroid thyroid JJ cord-023095-4dannjjm 1339 17 diseases disease NNS cord-023095-4dannjjm 1339 18 . . . cord-023095-4dannjjm 1340 1 We -PRON- PRP cord-023095-4dannjjm 1340 2 hypothesized hypothesize VBD cord-023095-4dannjjm 1340 3 that that IN cord-023095-4dannjjm 1340 4 TH TH NNP cord-023095-4dannjjm 1340 5 concentrations concentration NNS cord-023095-4dannjjm 1340 6 are be VBP cord-023095-4dannjjm 1340 7 different different JJ cord-023095-4dannjjm 1340 8 between between IN cord-023095-4dannjjm 1340 9 donkeys donkey NNS cord-023095-4dannjjm 1340 10 and and CC cord-023095-4dannjjm 1340 11 horses horse NNS cord-023095-4dannjjm 1340 12 . . . cord-023095-4dannjjm 1341 1 The the DT cord-023095-4dannjjm 1341 2 purposes purpose NNS cord-023095-4dannjjm 1341 3 of of IN cord-023095-4dannjjm 1341 4 this this DT cord-023095-4dannjjm 1341 5 study study NN cord-023095-4dannjjm 1341 6 were be VBD cord-023095-4dannjjm 1341 7 : : : cord-023095-4dannjjm 1341 8 a a LS cord-023095-4dannjjm 1341 9 ) ) -RRB- cord-023095-4dannjjm 1341 10 to to TO cord-023095-4dannjjm 1341 11 compare compare VB cord-023095-4dannjjm 1341 12 TH TH NNP cord-023095-4dannjjm 1341 13 concentrations concentration NNS cord-023095-4dannjjm 1341 14 between between IN cord-023095-4dannjjm 1341 15 donkeys donkey NNS cord-023095-4dannjjm 1341 16 and and CC cord-023095-4dannjjm 1341 17 horses horse NNS cord-023095-4dannjjm 1341 18 and and CC cord-023095-4dannjjm 1341 19 , , , cord-023095-4dannjjm 1341 20 b b LS cord-023095-4dannjjm 1341 21 ) ) -RRB- cord-023095-4dannjjm 1341 22 to to TO cord-023095-4dannjjm 1341 23 determine determine VB cord-023095-4dannjjm 1341 24 whether whether IN cord-023095-4dannjjm 1341 25 the the DT cord-023095-4dannjjm 1341 26 age age NN cord-023095-4dannjjm 1341 27 may may MD cord-023095-4dannjjm 1341 28 influence influence VB cord-023095-4dannjjm 1341 29 TH TH NNP cord-023095-4dannjjm 1341 30 concentrations concentration NNS cord-023095-4dannjjm 1341 31 . . . cord-023095-4dannjjm 1342 1 Thirty thirty CD cord-023095-4dannjjm 1342 2 - - HYPH cord-023095-4dannjjm 1342 3 eight eight CD cord-023095-4dannjjm 1342 4 healthy healthy JJ cord-023095-4dannjjm 1342 5 donkeys donkey NNS cord-023095-4dannjjm 1342 6 ( ( -LRB- cord-023095-4dannjjm 1342 7 8.5 8.5 CD cord-023095-4dannjjm 1342 8 AE AE NNP cord-023095-4dannjjm 1342 9 0.8 0.8 CD cord-023095-4dannjjm 1342 10 years year NNS cord-023095-4dannjjm 1342 11 ) ) -RRB- cord-023095-4dannjjm 1342 12 , , . cord-023095-4dannjjm 1343 1 mixed mixed JJ cord-023095-4dannjjm 1343 2 breeds breed NNS cord-023095-4dannjjm 1343 3 , , , cord-023095-4dannjjm 1343 4 and and CC cord-023095-4dannjjm 1343 5 20 20 CD cord-023095-4dannjjm 1343 6 healthy healthy JJ cord-023095-4dannjjm 1343 7 Andalusian andalusian JJ cord-023095-4dannjjm 1343 8 horses horse NNS cord-023095-4dannjjm 1343 9 ( ( -LRB- cord-023095-4dannjjm 1343 10 6.4 6.4 CD cord-023095-4dannjjm 1343 11 AE AE NNP cord-023095-4dannjjm 1343 12 0.5 0.5 CD cord-023095-4dannjjm 1343 13 years year NNS cord-023095-4dannjjm 1343 14 ) ) -RRB- cord-023095-4dannjjm 1343 15 were be VBD cord-023095-4dannjjm 1343 16 used use VBN cord-023095-4dannjjm 1343 17 . . . cord-023095-4dannjjm 1344 1 Donkeys donkey NNS cord-023095-4dannjjm 1344 2 were be VBD cord-023095-4dannjjm 1344 3 divided divide VBN cord-023095-4dannjjm 1344 4 into into IN cord-023095-4dannjjm 1344 5 three three CD cord-023095-4dannjjm 1344 6 groups group NNS cord-023095-4dannjjm 1344 7 : : : cord-023095-4dannjjm 1344 8 o o NN cord-023095-4dannjjm 1344 9 5 5 CD cord-023095-4dannjjm 1344 10 years year NNS cord-023095-4dannjjm 1344 11 ( ( -LRB- cord-023095-4dannjjm 1344 12 n n NN cord-023095-4dannjjm 1344 13 5 5 CD cord-023095-4dannjjm 1344 14 13 13 CD cord-023095-4dannjjm 1344 15 ) ) -RRB- cord-023095-4dannjjm 1344 16 , , , cord-023095-4dannjjm 1344 17 5 5 CD cord-023095-4dannjjm 1344 18 - - SYM cord-023095-4dannjjm 1344 19 10 10 CD cord-023095-4dannjjm 1344 20 years year NNS cord-023095-4dannjjm 1344 21 ( ( -LRB- cord-023095-4dannjjm 1344 22 n n NN cord-023095-4dannjjm 1344 23 5 5 CD cord-023095-4dannjjm 1344 24 12 12 CD cord-023095-4dannjjm 1344 25 ) ) -RRB- cord-023095-4dannjjm 1344 26 , , , cord-023095-4dannjjm 1344 27 and and CC cord-023095-4dannjjm 1344 28 411 411 CD cord-023095-4dannjjm 1344 29 years year NNS cord-023095-4dannjjm 1344 30 ( ( -LRB- cord-023095-4dannjjm 1344 31 n n NN cord-023095-4dannjjm 1344 32 5 5 CD cord-023095-4dannjjm 1344 33 13 13 CD cord-023095-4dannjjm 1344 34 ) ) -RRB- cord-023095-4dannjjm 1344 35 . . . cord-023095-4dannjjm 1345 1 Serum serum NN cord-023095-4dannjjm 1345 2 concentrations concentration NNS cord-023095-4dannjjm 1345 3 of of IN cord-023095-4dannjjm 1345 4 total total JJ cord-023095-4dannjjm 1345 5 triiodothyronine triiodothyronine NN cord-023095-4dannjjm 1345 6 ( ( -LRB- cord-023095-4dannjjm 1345 7 tT3 tT3 NNP cord-023095-4dannjjm 1345 8 ) ) -RRB- cord-023095-4dannjjm 1345 9 , , , cord-023095-4dannjjm 1345 10 free free JJ cord-023095-4dannjjm 1345 11 triiodothyronine triiodothyronine NN cord-023095-4dannjjm 1345 12 ( ( -LRB- cord-023095-4dannjjm 1345 13 fT3 ft3 NN cord-023095-4dannjjm 1345 14 ) ) -RRB- cord-023095-4dannjjm 1345 15 , , , cord-023095-4dannjjm 1345 16 total total JJ cord-023095-4dannjjm 1345 17 thyroxine thyroxine NN cord-023095-4dannjjm 1345 18 ( ( -LRB- cord-023095-4dannjjm 1345 19 tT4 tT4 NNP cord-023095-4dannjjm 1345 20 ) ) -RRB- cord-023095-4dannjjm 1345 21 , , , cord-023095-4dannjjm 1345 22 free free JJ cord-023095-4dannjjm 1345 23 thyroxine thyroxine NN cord-023095-4dannjjm 1345 24 ( ( -LRB- cord-023095-4dannjjm 1345 25 fT4 ft4 NN cord-023095-4dannjjm 1345 26 ) ) -RRB- cord-023095-4dannjjm 1345 27 , , . cord-023095-4dannjjm 1346 1 reverse reverse NNP cord-023095-4dannjjm 1346 2 triiodothyronine triiodothyronine NNP cord-023095-4dannjjm 1346 3 ( ( -LRB- cord-023095-4dannjjm 1346 4 rT3 rT3 NNP cord-023095-4dannjjm 1346 5 ) ) -RRB- cord-023095-4dannjjm 1346 6 and and CC cord-023095-4dannjjm 1346 7 thyroid thyroid NN cord-023095-4dannjjm 1346 8 - - HYPH cord-023095-4dannjjm 1346 9 stimulating stimulate VBG cord-023095-4dannjjm 1346 10 hormone hormone NN cord-023095-4dannjjm 1346 11 ( ( -LRB- cord-023095-4dannjjm 1346 12 TSH TSH NNP cord-023095-4dannjjm 1346 13 ) ) -RRB- cord-023095-4dannjjm 1346 14 were be VBD cord-023095-4dannjjm 1346 15 quantified quantify VBN cord-023095-4dannjjm 1346 16 by by IN cord-023095-4dannjjm 1346 17 radioimmunoassay radioimmunoassay JJ cord-023095-4dannjjm 1346 18 . . . cord-023095-4dannjjm 1347 1 All all DT cord-023095-4dannjjm 1347 2 blood blood NN cord-023095-4dannjjm 1347 3 samples sample NNS cord-023095-4dannjjm 1347 4 were be VBD cord-023095-4dannjjm 1347 5 collected collect VBN cord-023095-4dannjjm 1347 6 the the DT cord-023095-4dannjjm 1347 7 same same JJ cord-023095-4dannjjm 1347 8 day day NN cord-023095-4dannjjm 1347 9 . . . cord-023095-4dannjjm 1348 1 Neither neither CC cord-023095-4dannjjm 1348 2 horses horse NNS cord-023095-4dannjjm 1348 3 nor nor CC cord-023095-4dannjjm 1348 4 donkeys donkey NNS cord-023095-4dannjjm 1348 5 had have VBD cord-023095-4dannjjm 1348 6 received receive VBN cord-023095-4dannjjm 1348 7 any any DT cord-023095-4dannjjm 1348 8 treatment treatment NN cord-023095-4dannjjm 1348 9 for for IN cord-023095-4dannjjm 1348 10 30 30 CD cord-023095-4dannjjm 1348 11 days day NNS cord-023095-4dannjjm 1348 12 before before IN cord-023095-4dannjjm 1348 13 sampling sampling NN cord-023095-4dannjjm 1348 14 and and CC cord-023095-4dannjjm 1348 15 both both DT cord-023095-4dannjjm 1348 16 farms farm NNS cord-023095-4dannjjm 1348 17 had have VBD cord-023095-4dannjjm 1348 18 similar similar JJ cord-023095-4dannjjm 1348 19 production production NN cord-023095-4dannjjm 1348 20 conditions condition NNS cord-023095-4dannjjm 1348 21 . . . cord-023095-4dannjjm 1349 1 Total total JJ cord-023095-4dannjjm 1349 2 T3 T3 NNP cord-023095-4dannjjm 1349 3 , , , cord-023095-4dannjjm 1349 4 fT3 ft3 NN cord-023095-4dannjjm 1349 5 , , , cord-023095-4dannjjm 1349 6 fT4 ft4 VB cord-023095-4dannjjm 1349 7 and and CC cord-023095-4dannjjm 1349 8 tT4 tT4 NNP cord-023095-4dannjjm 1349 9 concentrations concentration NNS cord-023095-4dannjjm 1349 10 were be VBD cord-023095-4dannjjm 1349 11 higher high JJR cord-023095-4dannjjm 1349 12 ( ( -LRB- cord-023095-4dannjjm 1349 13 P p NN cord-023095-4dannjjm 1349 14 o o NN cord-023095-4dannjjm 1349 15 0.01 0.01 CD cord-023095-4dannjjm 1349 16 ) ) -RRB- cord-023095-4dannjjm 1349 17 in in IN cord-023095-4dannjjm 1349 18 donkeys donkey NNS cord-023095-4dannjjm 1349 19 than than IN cord-023095-4dannjjm 1349 20 horses horse NNS cord-023095-4dannjjm 1349 21 . . . cord-023095-4dannjjm 1350 1 In in IN cord-023095-4dannjjm 1350 2 contrast contrast NN cord-023095-4dannjjm 1350 3 , , , cord-023095-4dannjjm 1350 4 no no DT cord-023095-4dannjjm 1350 5 statistical statistical JJ cord-023095-4dannjjm 1350 6 differences difference NNS cord-023095-4dannjjm 1350 7 were be VBD cord-023095-4dannjjm 1350 8 found find VBN cord-023095-4dannjjm 1350 9 for for IN cord-023095-4dannjjm 1350 10 rT3 rt3 NN cord-023095-4dannjjm 1350 11 and and CC cord-023095-4dannjjm 1350 12 TSH TSH NNP cord-023095-4dannjjm 1350 13 concentrations concentration NNS cord-023095-4dannjjm 1350 14 . . . cord-023095-4dannjjm 1351 1 Young young JJ cord-023095-4dannjjm 1351 2 donkeys donkey NNS cord-023095-4dannjjm 1351 3 ( ( -LRB- cord-023095-4dannjjm 1351 4 o o NN cord-023095-4dannjjm 1351 5 5 5 CD cord-023095-4dannjjm 1351 6 years year NNS cord-023095-4dannjjm 1351 7 ) ) -RRB- cord-023095-4dannjjm 1351 8 had have VBD cord-023095-4dannjjm 1351 9 higher high JJR cord-023095-4dannjjm 1351 10 fT4 ft4 NN cord-023095-4dannjjm 1351 11 , , , cord-023095-4dannjjm 1351 12 tT4 tT4 NNP cord-023095-4dannjjm 1351 13 and and CC cord-023095-4dannjjm 1351 14 rT3 rt3 JJ cord-023095-4dannjjm 1351 15 concentrations concentration NNS cord-023095-4dannjjm 1351 16 compared compare VBN cord-023095-4dannjjm 1351 17 to to IN cord-023095-4dannjjm 1351 18 other other JJ cord-023095-4dannjjm 1351 19 donkey donkey NN cord-023095-4dannjjm 1351 20 groups group NNS cord-023095-4dannjjm 1351 21 ( ( -LRB- cord-023095-4dannjjm 1351 22 P p NN cord-023095-4dannjjm 1351 23 o o NN cord-023095-4dannjjm 1351 24 0.05 0.05 CD cord-023095-4dannjjm 1351 25 ) ) -RRB- cord-023095-4dannjjm 1351 26 . . . cord-023095-4dannjjm 1352 1 Old old JJ cord-023095-4dannjjm 1352 2 donkeys donkey NNS cord-023095-4dannjjm 1352 3 ( ( -LRB- cord-023095-4dannjjm 1352 4 411 411 CD cord-023095-4dannjjm 1352 5 years year NNS cord-023095-4dannjjm 1352 6 ) ) -RRB- cord-023095-4dannjjm 1352 7 had have VBD cord-023095-4dannjjm 1352 8 lower low JJR cord-023095-4dannjjm 1352 9 tT3 tt3 NN cord-023095-4dannjjm 1352 10 and and CC cord-023095-4dannjjm 1352 11 fT3 ft3 NN cord-023095-4dannjjm 1352 12 concentrations concentration NNS cord-023095-4dannjjm 1352 13 than than IN cord-023095-4dannjjm 1352 14 both both DT cord-023095-4dannjjm 1352 15 younger young JJR cord-023095-4dannjjm 1352 16 donkeys donkey NNS cord-023095-4dannjjm 1352 17 groups group NNS cord-023095-4dannjjm 1352 18 ( ( -LRB- cord-023095-4dannjjm 1352 19 P p NN cord-023095-4dannjjm 1352 20 o o NN cord-023095-4dannjjm 1352 21 0.05 0.05 CD cord-023095-4dannjjm 1352 22 ) ) -RRB- cord-023095-4dannjjm 1352 23 . . . cord-023095-4dannjjm 1353 1 This this DT cord-023095-4dannjjm 1353 2 study study NN cord-023095-4dannjjm 1353 3 shows show VBZ cord-023095-4dannjjm 1353 4 that that IN cord-023095-4dannjjm 1353 5 there there EX cord-023095-4dannjjm 1353 6 are be VBP cord-023095-4dannjjm 1353 7 differences difference NNS cord-023095-4dannjjm 1353 8 in in IN cord-023095-4dannjjm 1353 9 TH TH NNP cord-023095-4dannjjm 1353 10 concentrations concentration NNS cord-023095-4dannjjm 1353 11 between between IN cord-023095-4dannjjm 1353 12 donkeys donkey NNS cord-023095-4dannjjm 1353 13 and and CC cord-023095-4dannjjm 1353 14 horses horse NNS cord-023095-4dannjjm 1353 15 , , , cord-023095-4dannjjm 1353 16 raising raise VBG cord-023095-4dannjjm 1353 17 awareness awareness NN cord-023095-4dannjjm 1353 18 on on IN cord-023095-4dannjjm 1353 19 the the DT cord-023095-4dannjjm 1353 20 possibility possibility NN cord-023095-4dannjjm 1353 21 of of IN cord-023095-4dannjjm 1353 22 misdiagnosis misdiagnosis NN cord-023095-4dannjjm 1353 23 of of IN cord-023095-4dannjjm 1353 24 thyroid thyroid JJ cord-023095-4dannjjm 1353 25 gland gland NN cord-023095-4dannjjm 1353 26 dysfunction dysfunction NN cord-023095-4dannjjm 1353 27 when when WRB cord-023095-4dannjjm 1353 28 using use VBG cord-023095-4dannjjm 1353 29 values value NNS cord-023095-4dannjjm 1353 30 from from IN cord-023095-4dannjjm 1353 31 horses horse NNS cord-023095-4dannjjm 1353 32 , , , cord-023095-4dannjjm 1353 33 being be VBG cord-023095-4dannjjm 1353 34 necessary necessary JJ cord-023095-4dannjjm 1353 35 to to TO cord-023095-4dannjjm 1353 36 determine determine VB cord-023095-4dannjjm 1353 37 exclusive exclusive JJ cord-023095-4dannjjm 1353 38 reference reference NN cord-023095-4dannjjm 1353 39 intervals interval NNS cord-023095-4dannjjm 1353 40 for for IN cord-023095-4dannjjm 1353 41 donkeys donkey NNS cord-023095-4dannjjm 1353 42 . . . cord-023095-4dannjjm 1354 1 Ovariectomy Ovariectomy NNP cord-023095-4dannjjm 1354 2 is be VBZ cord-023095-4dannjjm 1354 3 associated associate VBN cord-023095-4dannjjm 1354 4 with with IN cord-023095-4dannjjm 1354 5 alterations alteration NNS cord-023095-4dannjjm 1354 6 of of IN cord-023095-4dannjjm 1354 7 responses response NNS cord-023095-4dannjjm 1354 8 to to IN cord-023095-4dannjjm 1354 9 many many JJ cord-023095-4dannjjm 1354 10 hormones hormone NNS cord-023095-4dannjjm 1354 11 , , , cord-023095-4dannjjm 1354 12 not not RB cord-023095-4dannjjm 1354 13 just just RB cord-023095-4dannjjm 1354 14 those those DT cord-023095-4dannjjm 1354 15 associated associate VBN cord-023095-4dannjjm 1354 16 with with IN cord-023095-4dannjjm 1354 17 reproductive reproductive JJ cord-023095-4dannjjm 1354 18 function function NN cord-023095-4dannjjm 1354 19 . . . cord-023095-4dannjjm 1355 1 In in IN cord-023095-4dannjjm 1355 2 humans human NNS cord-023095-4dannjjm 1355 3 and and CC cord-023095-4dannjjm 1355 4 rats rat NNS cord-023095-4dannjjm 1355 5 , , , cord-023095-4dannjjm 1355 6 ovariectomy ovariectomy NN cord-023095-4dannjjm 1355 7 leads lead VBZ cord-023095-4dannjjm 1355 8 to to IN cord-023095-4dannjjm 1355 9 insulin insulin NN cord-023095-4dannjjm 1355 10 resistance resistance NN cord-023095-4dannjjm 1355 11 , , , cord-023095-4dannjjm 1355 12 increased increase VBD cord-023095-4dannjjm 1355 13 adiposity adiposity NN cord-023095-4dannjjm 1355 14 and and CC cord-023095-4dannjjm 1355 15 altered alter VBN cord-023095-4dannjjm 1355 16 fat fat JJ cord-023095-4dannjjm 1355 17 mobilization mobilization NN cord-023095-4dannjjm 1355 18 . . . cord-023095-4dannjjm 1356 1 The the DT cord-023095-4dannjjm 1356 2 effects effect NNS cord-023095-4dannjjm 1356 3 of of IN cord-023095-4dannjjm 1356 4 ovariectomy ovariectomy NN cord-023095-4dannjjm 1356 5 on on IN cord-023095-4dannjjm 1356 6 energy energy NN cord-023095-4dannjjm 1356 7 metabolism metabolism NN cord-023095-4dannjjm 1356 8 have have VBP cord-023095-4dannjjm 1356 9 not not RB cord-023095-4dannjjm 1356 10 been be VBN cord-023095-4dannjjm 1356 11 reported report VBN cord-023095-4dannjjm 1356 12 in in IN cord-023095-4dannjjm 1356 13 horses horse NNS cord-023095-4dannjjm 1356 14 . . . cord-023095-4dannjjm 1357 1 Ovariectomized Ovariectomized NNP cord-023095-4dannjjm 1357 2 mares mare NNS cord-023095-4dannjjm 1357 3 have have VBP cord-023095-4dannjjm 1357 4 been be VBN cord-023095-4dannjjm 1357 5 shown show VBN cord-023095-4dannjjm 1357 6 to to TO cord-023095-4dannjjm 1357 7 respond respond VB cord-023095-4dannjjm 1357 8 normally normally RB cord-023095-4dannjjm 1357 9 to to IN cord-023095-4dannjjm 1357 10 an an DT cord-023095-4dannjjm 1357 11 ACTH ACTH NNP cord-023095-4dannjjm 1357 12 stimulation stimulation NN cord-023095-4dannjjm 1357 13 test test NN cord-023095-4dannjjm 1357 14 , , , cord-023095-4dannjjm 1357 15 but but CC cord-023095-4dannjjm 1357 16 the the DT cord-023095-4dannjjm 1357 17 response response NN cord-023095-4dannjjm 1357 18 to to IN cord-023095-4dannjjm 1357 19 suppression suppression NN cord-023095-4dannjjm 1357 20 of of IN cord-023095-4dannjjm 1357 21 the the DT cord-023095-4dannjjm 1357 22 hypothalamo hypothalamo JJ cord-023095-4dannjjm 1357 23 - - HYPH cord-023095-4dannjjm 1357 24 pituitary pituitary NN cord-023095-4dannjjm 1357 25 - - HYPH cord-023095-4dannjjm 1357 26 adrenal adrenal NN cord-023095-4dannjjm 1357 27 axis axis NN cord-023095-4dannjjm 1357 28 has have VBZ cord-023095-4dannjjm 1357 29 not not RB cord-023095-4dannjjm 1357 30 been be VBN cord-023095-4dannjjm 1357 31 previously previously RB cord-023095-4dannjjm 1357 32 described describe VBN cord-023095-4dannjjm 1357 33 . . . cord-023095-4dannjjm 1358 1 The the DT cord-023095-4dannjjm 1358 2 aim aim NN cord-023095-4dannjjm 1358 3 of of IN cord-023095-4dannjjm 1358 4 this this DT cord-023095-4dannjjm 1358 5 study study NN cord-023095-4dannjjm 1358 6 was be VBD cord-023095-4dannjjm 1358 7 to to TO cord-023095-4dannjjm 1358 8 evaluate evaluate VB cord-023095-4dannjjm 1358 9 the the DT cord-023095-4dannjjm 1358 10 effect effect NN cord-023095-4dannjjm 1358 11 of of IN cord-023095-4dannjjm 1358 12 ovariectomy ovariectomy NN cord-023095-4dannjjm 1358 13 on on IN cord-023095-4dannjjm 1358 14 insulin insulin NN cord-023095-4dannjjm 1358 15 response response NN cord-023095-4dannjjm 1358 16 in in IN cord-023095-4dannjjm 1358 17 mares mare NNS cord-023095-4dannjjm 1358 18 and and CC cord-023095-4dannjjm 1358 19 to to TO cord-023095-4dannjjm 1358 20 determine determine VB cord-023095-4dannjjm 1358 21 if if IN cord-023095-4dannjjm 1358 22 mares mare NNS cord-023095-4dannjjm 1358 23 exhibit exhibit VBP cord-023095-4dannjjm 1358 24 alterations alteration NNS cord-023095-4dannjjm 1358 25 in in IN cord-023095-4dannjjm 1358 26 response response NN cord-023095-4dannjjm 1358 27 to to IN cord-023095-4dannjjm 1358 28 dexamethasone dexamethasone NNP cord-023095-4dannjjm 1358 29 administration administration NN cord-023095-4dannjjm 1358 30 after after IN cord-023095-4dannjjm 1358 31 ovariectomy ovariectomy NN cord-023095-4dannjjm 1358 32 . . . cord-023095-4dannjjm 1359 1 Six six CD cord-023095-4dannjjm 1359 2 healthy healthy JJ cord-023095-4dannjjm 1359 3 mares mare NNS cord-023095-4dannjjm 1359 4 underwent undergo VBD cord-023095-4dannjjm 1359 5 an an DT cord-023095-4dannjjm 1359 6 intravenous intravenous JJ cord-023095-4dannjjm 1359 7 glucose glucose NN cord-023095-4dannjjm 1359 8 tolerance tolerance NN cord-023095-4dannjjm 1359 9 test test NN cord-023095-4dannjjm 1359 10 ( ( -LRB- cord-023095-4dannjjm 1359 11 IVGTT IVGTT NNP cord-023095-4dannjjm 1359 12 ) ) -RRB- cord-023095-4dannjjm 1359 13 , , , cord-023095-4dannjjm 1359 14 an an DT cord-023095-4dannjjm 1359 15 insulin insulin NN cord-023095-4dannjjm 1359 16 sensitivity sensitivity NN cord-023095-4dannjjm 1359 17 test test NN cord-023095-4dannjjm 1359 18 ( ( -LRB- cord-023095-4dannjjm 1359 19 IST IST NNP cord-023095-4dannjjm 1359 20 ) ) -RRB- cord-023095-4dannjjm 1359 21 and and CC cord-023095-4dannjjm 1359 22 a a DT cord-023095-4dannjjm 1359 23 dexamethasone dexamethasone NN cord-023095-4dannjjm 1359 24 suppression suppression NN cord-023095-4dannjjm 1359 25 test test NN cord-023095-4dannjjm 1359 26 ( ( -LRB- cord-023095-4dannjjm 1359 27 DST DST NNP cord-023095-4dannjjm 1359 28 ) ) -RRB- cord-023095-4dannjjm 1359 29 before before IN cord-023095-4dannjjm 1359 30 and and CC cord-023095-4dannjjm 1359 31 5 5 CD cord-023095-4dannjjm 1359 32 weeks week NNS cord-023095-4dannjjm 1359 33 after after IN cord-023095-4dannjjm 1359 34 bilateral bilateral JJ cord-023095-4dannjjm 1359 35 ovariectomy ovariectomy NN cord-023095-4dannjjm 1359 36 . . . cord-023095-4dannjjm 1360 1 Body body NN cord-023095-4dannjjm 1360 2 weight weight NN cord-023095-4dannjjm 1360 3 , , , cord-023095-4dannjjm 1360 4 cortisol cortisol NN cord-023095-4dannjjm 1360 5 values value NNS cord-023095-4dannjjm 1360 6 at at IN cord-023095-4dannjjm 1360 7 baseline baseline NN cord-023095-4dannjjm 1360 8 , , , cord-023095-4dannjjm 1360 9 15 15 CD cord-023095-4dannjjm 1360 10 and and CC cord-023095-4dannjjm 1360 11 24 24 CD cord-023095-4dannjjm 1360 12 hours hour NNS cord-023095-4dannjjm 1360 13 after after IN cord-023095-4dannjjm 1360 14 dexamethasone dexamethasone NN cord-023095-4dannjjm 1360 15 injection injection NN cord-023095-4dannjjm 1360 16 and and CC cord-023095-4dannjjm 1360 17 ACTH ACTH NNP cord-023095-4dannjjm 1360 18 values value NNS cord-023095-4dannjjm 1360 19 at at IN cord-023095-4dannjjm 1360 20 baseline baseline NN cord-023095-4dannjjm 1360 21 , , , cord-023095-4dannjjm 1360 22 15 15 CD cord-023095-4dannjjm 1360 23 and and CC cord-023095-4dannjjm 1360 24 24 24 CD cord-023095-4dannjjm 1360 25 hours hour NNS cord-023095-4dannjjm 1360 26 after after IN cord-023095-4dannjjm 1360 27 dexamethasone dexamethasone NN cord-023095-4dannjjm 1360 28 injection injection NN cord-023095-4dannjjm 1360 29 , , , cord-023095-4dannjjm 1360 30 basal basal JJ cord-023095-4dannjjm 1360 31 insulin insulin NN cord-023095-4dannjjm 1360 32 / / SYM cord-023095-4dannjjm 1360 33 glucose glucose NN cord-023095-4dannjjm 1360 34 ratio ratio NN cord-023095-4dannjjm 1360 35 , , , cord-023095-4dannjjm 1360 36 time time NN cord-023095-4dannjjm 1360 37 to to TO cord-023095-4dannjjm 1360 38 reach reach VB cord-023095-4dannjjm 1360 39 a a DT cord-023095-4dannjjm 1360 40 60 60 CD cord-023095-4dannjjm 1360 41 % % NN cord-023095-4dannjjm 1360 42 decrease decrease NN cord-023095-4dannjjm 1360 43 in in IN cord-023095-4dannjjm 1360 44 blood blood NN cord-023095-4dannjjm 1360 45 glucose glucose NN cord-023095-4dannjjm 1360 46 in in IN cord-023095-4dannjjm 1360 47 the the DT cord-023095-4dannjjm 1360 48 IST IST NNP cord-023095-4dannjjm 1360 49 , , , cord-023095-4dannjjm 1360 50 time time NN cord-023095-4dannjjm 1360 51 to to TO cord-023095-4dannjjm 1360 52 reach reach VB cord-023095-4dannjjm 1360 53 baseline baseline JJ cord-023095-4dannjjm 1360 54 glucose glucose NN cord-023095-4dannjjm 1360 55 concentration concentration NN cord-023095-4dannjjm 1360 56 in in IN cord-023095-4dannjjm 1360 57 the the DT cord-023095-4dannjjm 1360 58 IVGTT IVGTT NNP cord-023095-4dannjjm 1360 59 and and CC cord-023095-4dannjjm 1360 60 area area NN cord-023095-4dannjjm 1360 61 under under IN cord-023095-4dannjjm 1360 62 the the DT cord-023095-4dannjjm 1360 63 curves curve NNS cord-023095-4dannjjm 1360 64 plotting plot VBG cord-023095-4dannjjm 1360 65 blood blood NN cord-023095-4dannjjm 1360 66 glucose glucose NN cord-023095-4dannjjm 1360 67 and and CC cord-023095-4dannjjm 1360 68 time time NN cord-023095-4dannjjm 1360 69 to to IN cord-023095-4dannjjm 1360 70 injection injection NN cord-023095-4dannjjm 1360 71 of of IN cord-023095-4dannjjm 1360 72 glucose glucose NN cord-023095-4dannjjm 1360 73 or or CC cord-023095-4dannjjm 1360 74 insulin insulin NN cord-023095-4dannjjm 1360 75 were be VBD cord-023095-4dannjjm 1360 76 compared compare VBN cord-023095-4dannjjm 1360 77 before before RB cord-023095-4dannjjm 1360 78 and and CC cord-023095-4dannjjm 1360 79 after after IN cord-023095-4dannjjm 1360 80 ovariectomy ovariectomy NN cord-023095-4dannjjm 1360 81 using use VBG cord-023095-4dannjjm 1360 82 a a DT cord-023095-4dannjjm 1360 83 paired paired JJ cord-023095-4dannjjm 1360 84 t t NN cord-023095-4dannjjm 1360 85 - - HYPH cord-023095-4dannjjm 1360 86 test test NN cord-023095-4dannjjm 1360 87 or or CC cord-023095-4dannjjm 1360 88 an an DT cord-023095-4dannjjm 1360 89 ANOVA anova NN cord-023095-4dannjjm 1360 90 for for IN cord-023095-4dannjjm 1360 91 repeated repeat VBN cord-023095-4dannjjm 1360 92 measures measure NNS cord-023095-4dannjjm 1360 93 . . . cord-023095-4dannjjm 1361 1 Significance significance NN cord-023095-4dannjjm 1361 2 level level NN cord-023095-4dannjjm 1361 3 was be VBD cord-023095-4dannjjm 1361 4 P p NN cord-023095-4dannjjm 1361 5 o o NN cord-023095-4dannjjm 1361 6 0.05 0.05 CD cord-023095-4dannjjm 1361 7 . . . cord-023095-4dannjjm 1362 1 Average average JJ cord-023095-4dannjjm 1362 2 body body NN cord-023095-4dannjjm 1362 3 weight weight NN cord-023095-4dannjjm 1362 4 was be VBD cord-023095-4dannjjm 1362 5 decreased decrease VBN cord-023095-4dannjjm 1362 6 after after IN cord-023095-4dannjjm 1362 7 surgery surgery NN cord-023095-4dannjjm 1362 8 ( ( -LRB- cord-023095-4dannjjm 1362 9 6 6 CD cord-023095-4dannjjm 1362 10 kg kg NN cord-023095-4dannjjm 1362 11 ) ) -RRB- cord-023095-4dannjjm 1362 12 . . . cord-023095-4dannjjm 1363 1 The the DT cord-023095-4dannjjm 1363 2 injection injection NN cord-023095-4dannjjm 1363 3 of of IN cord-023095-4dannjjm 1363 4 dexamethasone dexamethasone NN cord-023095-4dannjjm 1363 5 resulted result VBD cord-023095-4dannjjm 1363 6 in in IN cord-023095-4dannjjm 1363 7 a a DT cord-023095-4dannjjm 1363 8 serum serum NN cord-023095-4dannjjm 1363 9 cortisol cortisol NN cord-023095-4dannjjm 1363 10 concentration concentration NN cord-023095-4dannjjm 1363 11 of of IN cord-023095-4dannjjm 1363 12 less less JJR cord-023095-4dannjjm 1363 13 than than IN cord-023095-4dannjjm 1363 14 1 1 CD cord-023095-4dannjjm 1363 15 mg mg NNP cord-023095-4dannjjm 1363 16 / / SYM cord-023095-4dannjjm 1363 17 dL dl NN cord-023095-4dannjjm 1363 18 in in IN cord-023095-4dannjjm 1363 19 all all DT cord-023095-4dannjjm 1363 20 mares mare NNS cord-023095-4dannjjm 1363 21 before before IN cord-023095-4dannjjm 1363 22 ovariectomy ovariectomy NN cord-023095-4dannjjm 1363 23 , , , cord-023095-4dannjjm 1363 24 whereas whereas IN cord-023095-4dannjjm 1363 25 after after IN cord-023095-4dannjjm 1363 26 ovariectomy ovariectomy NN cord-023095-4dannjjm 1363 27 , , , cord-023095-4dannjjm 1363 28 dexamethasone dexamethasone NN cord-023095-4dannjjm 1363 29 injection injection NN cord-023095-4dannjjm 1363 30 resulted result VBD cord-023095-4dannjjm 1363 31 in in IN cord-023095-4dannjjm 1363 32 a a DT cord-023095-4dannjjm 1363 33 serum serum NN cord-023095-4dannjjm 1363 34 cortisol cortisol NN cord-023095-4dannjjm 1363 35 concentration concentration NN cord-023095-4dannjjm 1363 36 of of IN cord-023095-4dannjjm 1363 37 less less JJR cord-023095-4dannjjm 1363 38 than than IN cord-023095-4dannjjm 1363 39 1 1 CD cord-023095-4dannjjm 1363 40 mg mg NNP cord-023095-4dannjjm 1363 41 / / SYM cord-023095-4dannjjm 1363 42 dL dl NN cord-023095-4dannjjm 1363 43 in in IN cord-023095-4dannjjm 1363 44 5 5 CD cord-023095-4dannjjm 1363 45 out out IN cord-023095-4dannjjm 1363 46 of of IN cord-023095-4dannjjm 1363 47 6 6 CD cord-023095-4dannjjm 1363 48 mares mare NNS cord-023095-4dannjjm 1363 49 . . . cord-023095-4dannjjm 1364 1 In in IN cord-023095-4dannjjm 1364 2 all all DT cord-023095-4dannjjm 1364 3 cases case NNS cord-023095-4dannjjm 1364 4 , , , cord-023095-4dannjjm 1364 5 ACTH ACTH NNP cord-023095-4dannjjm 1364 6 concentration concentration NN cord-023095-4dannjjm 1364 7 was be VBD cord-023095-4dannjjm 1364 8 within within IN cord-023095-4dannjjm 1364 9 the the DT cord-023095-4dannjjm 1364 10 reference reference NN cord-023095-4dannjjm 1364 11 range range NN cord-023095-4dannjjm 1364 12 ( ( -LRB- cord-023095-4dannjjm 1364 13 9 9 CD cord-023095-4dannjjm 1364 14 - - SYM cord-023095-4dannjjm 1364 15 35 35 CD cord-023095-4dannjjm 1364 16 pg pg NN cord-023095-4dannjjm 1364 17 / / SYM cord-023095-4dannjjm 1364 18 mL mL NNP cord-023095-4dannjjm 1364 19 ) ) -RRB- cord-023095-4dannjjm 1364 20 before before IN cord-023095-4dannjjm 1364 21 and and CC cord-023095-4dannjjm 1364 22 after after IN cord-023095-4dannjjm 1364 23 ovariectomy ovariectomy NN cord-023095-4dannjjm 1364 24 . . . cord-023095-4dannjjm 1365 1 However however RB cord-023095-4dannjjm 1365 2 , , , cord-023095-4dannjjm 1365 3 ACTH ACTH NNP cord-023095-4dannjjm 1365 4 concentrations concentration NNS cord-023095-4dannjjm 1365 5 at at IN cord-023095-4dannjjm 1365 6 t t NN cord-023095-4dannjjm 1365 7 0 0 CD cord-023095-4dannjjm 1365 8 and and CC cord-023095-4dannjjm 1365 9 at at IN cord-023095-4dannjjm 1365 10 t t NNP cord-023095-4dannjjm 1365 11 15 15 CD cord-023095-4dannjjm 1365 12 were be VBD cord-023095-4dannjjm 1365 13 significantly significantly RB cord-023095-4dannjjm 1365 14 higher high JJR cord-023095-4dannjjm 1365 15 after after IN cord-023095-4dannjjm 1365 16 ovariectomy ovariectomy NN cord-023095-4dannjjm 1365 17 . . . cord-023095-4dannjjm 1366 1 Each each DT cord-023095-4dannjjm 1366 2 mare mare NN cord-023095-4dannjjm 1366 3 had have VBD cord-023095-4dannjjm 1366 4 a a DT cord-023095-4dannjjm 1366 5 normal normal JJ cord-023095-4dannjjm 1366 6 IVGTT IVGTT NNP cord-023095-4dannjjm 1366 7 , , , cord-023095-4dannjjm 1366 8 both both CC cord-023095-4dannjjm 1366 9 before before IN cord-023095-4dannjjm 1366 10 and and CC cord-023095-4dannjjm 1366 11 after after IN cord-023095-4dannjjm 1366 12 ovariectomy ovariectomy NN cord-023095-4dannjjm 1366 13 . . . cord-023095-4dannjjm 1367 1 Additionally additionally RB cord-023095-4dannjjm 1367 2 , , , cord-023095-4dannjjm 1367 3 no no DT cord-023095-4dannjjm 1367 4 significant significant JJ cord-023095-4dannjjm 1367 5 differences difference NNS cord-023095-4dannjjm 1367 6 were be VBD cord-023095-4dannjjm 1367 7 observed observe VBN cord-023095-4dannjjm 1367 8 in in IN cord-023095-4dannjjm 1367 9 basal basal JJ cord-023095-4dannjjm 1367 10 blood blood NN cord-023095-4dannjjm 1367 11 glucose glucose NN cord-023095-4dannjjm 1367 12 ( ( -LRB- cord-023095-4dannjjm 1367 13 84 84 CD cord-023095-4dannjjm 1367 14 AE AE NNP cord-023095-4dannjjm 1367 15 12 12 CD cord-023095-4dannjjm 1367 16 mg mg NNP cord-023095-4dannjjm 1367 17 / / SYM cord-023095-4dannjjm 1367 18 dL dl NN cord-023095-4dannjjm 1367 19 before before RB cord-023095-4dannjjm 1367 20 and and CC cord-023095-4dannjjm 1367 21 85 85 CD cord-023095-4dannjjm 1367 22 AE AE NNP cord-023095-4dannjjm 1368 1 3 3 CD cord-023095-4dannjjm 1368 2 mg mg NN cord-023095-4dannjjm 1368 3 / / SYM cord-023095-4dannjjm 1368 4 dL dl NN cord-023095-4dannjjm 1368 5 after after IN cord-023095-4dannjjm 1368 6 ) ) -RRB- cord-023095-4dannjjm 1368 7 or or CC cord-023095-4dannjjm 1368 8 in in IN cord-023095-4dannjjm 1368 9 the the DT cord-023095-4dannjjm 1368 10 time time NN cord-023095-4dannjjm 1368 11 to to TO cord-023095-4dannjjm 1368 12 reach reach VB cord-023095-4dannjjm 1368 13 glucose glucose NN cord-023095-4dannjjm 1368 14 baseline baseline NN cord-023095-4dannjjm 1368 15 ( ( -LRB- cord-023095-4dannjjm 1368 16 108 108 CD cord-023095-4dannjjm 1368 17 AE AE NNP cord-023095-4dannjjm 1368 18 66 66 CD cord-023095-4dannjjm 1368 19 min min NN cord-023095-4dannjjm 1368 20 before before RB cord-023095-4dannjjm 1368 21 and and CC cord-023095-4dannjjm 1368 22 99 99 CD cord-023095-4dannjjm 1368 23 AE AE NNP cord-023095-4dannjjm 1368 24 51 51 CD cord-023095-4dannjjm 1368 25 min min NN cord-023095-4dannjjm 1368 26 after after RB cord-023095-4dannjjm 1368 27 ) ) -RRB- cord-023095-4dannjjm 1368 28 . . . cord-023095-4dannjjm 1369 1 Serum serum NN cord-023095-4dannjjm 1369 2 basal basal NN cord-023095-4dannjjm 1369 3 insulin insulin NN cord-023095-4dannjjm 1369 4 concentration concentration NN cord-023095-4dannjjm 1369 5 and and CC cord-023095-4dannjjm 1369 6 insulin insulin NN cord-023095-4dannjjm 1369 7 / / SYM cord-023095-4dannjjm 1369 8 glucose glucose NN cord-023095-4dannjjm 1369 9 ratio ratio NN cord-023095-4dannjjm 1369 10 was be VBD cord-023095-4dannjjm 1369 11 not not RB cord-023095-4dannjjm 1369 12 significantly significantly RB cord-023095-4dannjjm 1369 13 different different JJ cord-023095-4dannjjm 1369 14 before before IN cord-023095-4dannjjm 1369 15 or or CC cord-023095-4dannjjm 1369 16 after after IN cord-023095-4dannjjm 1369 17 ovariectomy ovariectomy NN cord-023095-4dannjjm 1369 18 ( ( -LRB- cord-023095-4dannjjm 1369 19 22.0 22.0 CD cord-023095-4dannjjm 1369 20 AE AE NNP cord-023095-4dannjjm 1369 21 7.9 7.9 CD cord-023095-4dannjjm 1369 22 mIU mIU NNP cord-023095-4dannjjm 1369 23 / / SYM cord-023095-4dannjjm 1369 24 mL ml NN cord-023095-4dannjjm 1369 25 and and CC cord-023095-4dannjjm 1369 26 17.5 17.5 CD cord-023095-4dannjjm 1369 27 AE AE NNP cord-023095-4dannjjm 1369 28 8.9 8.9 CD cord-023095-4dannjjm 1369 29 mIU mIU NNP cord-023095-4dannjjm 1369 30 / / SYM cord-023095-4dannjjm 1369 31 mL ml NN cord-023095-4dannjjm 1369 32 and and CC cord-023095-4dannjjm 1369 33 0.26 0.26 CD cord-023095-4dannjjm 1369 34 AE AE NNP cord-023095-4dannjjm 1369 35 0.09 0.09 CD cord-023095-4dannjjm 1369 36 and and CC cord-023095-4dannjjm 1369 37 0.20 0.20 CD cord-023095-4dannjjm 1369 38 AE AE NNP cord-023095-4dannjjm 1369 39 0.10 0.10 CD cord-023095-4dannjjm 1369 40 , , , cord-023095-4dannjjm 1369 41 respectively respectively RB cord-023095-4dannjjm 1369 42 ) ) -RRB- cord-023095-4dannjjm 1369 43 , , , cord-023095-4dannjjm 1369 44 nor nor CC cord-023095-4dannjjm 1369 45 was be VBD cord-023095-4dannjjm 1369 46 the the DT cord-023095-4dannjjm 1369 47 average average JJ cord-023095-4dannjjm 1369 48 time time NN cord-023095-4dannjjm 1369 49 to to TO cord-023095-4dannjjm 1369 50 reach reach VB cord-023095-4dannjjm 1369 51 a a DT cord-023095-4dannjjm 1369 52 60 60 CD cord-023095-4dannjjm 1369 53 % % NN cord-023095-4dannjjm 1369 54 decrease decrease NN cord-023095-4dannjjm 1369 55 in in IN cord-023095-4dannjjm 1369 56 blood blood NN cord-023095-4dannjjm 1369 57 glucose glucose NN cord-023095-4dannjjm 1369 58 after after IN cord-023095-4dannjjm 1369 59 insulin insulin NN cord-023095-4dannjjm 1369 60 injection injection NN cord-023095-4dannjjm 1369 61 ( ( -LRB- cord-023095-4dannjjm 1369 62 30 30 CD cord-023095-4dannjjm 1369 63 AE AE NNP cord-023095-4dannjjm 1369 64 7 7 CD cord-023095-4dannjjm 1369 65 min min NN cord-023095-4dannjjm 1369 66 and and CC cord-023095-4dannjjm 1369 67 25 25 CD cord-023095-4dannjjm 1369 68 AE AE NNP cord-023095-4dannjjm 1369 69 9 9 CD cord-023095-4dannjjm 1369 70 min min NN cord-023095-4dannjjm 1369 71 , , , cord-023095-4dannjjm 1369 72 respectively respectively RB cord-023095-4dannjjm 1369 73 ) ) -RRB- cord-023095-4dannjjm 1369 74 . . . cord-023095-4dannjjm 1370 1 These these DT cord-023095-4dannjjm 1370 2 findings finding NNS cord-023095-4dannjjm 1370 3 suggest suggest VBP cord-023095-4dannjjm 1370 4 that that IN cord-023095-4dannjjm 1370 5 , , , cord-023095-4dannjjm 1370 6 as as IN cord-023095-4dannjjm 1370 7 reported report VBN cord-023095-4dannjjm 1370 8 in in IN cord-023095-4dannjjm 1370 9 other other JJ cord-023095-4dannjjm 1370 10 species specie NNS cord-023095-4dannjjm 1370 11 , , , cord-023095-4dannjjm 1370 12 the the DT cord-023095-4dannjjm 1370 13 shortterm shortterm JJ cord-023095-4dannjjm 1370 14 effect effect NN cord-023095-4dannjjm 1370 15 of of IN cord-023095-4dannjjm 1370 16 ovariectomy ovariectomy NN cord-023095-4dannjjm 1370 17 may may MD cord-023095-4dannjjm 1370 18 modify modify VB cord-023095-4dannjjm 1370 19 dexamethasone dexamethasone NN cord-023095-4dannjjm 1370 20 response response NN cord-023095-4dannjjm 1370 21 in in IN cord-023095-4dannjjm 1370 22 mares mare NNS cord-023095-4dannjjm 1370 23 and and CC cord-023095-4dannjjm 1370 24 that that IN cord-023095-4dannjjm 1370 25 , , , cord-023095-4dannjjm 1370 26 contrary contrary JJ cord-023095-4dannjjm 1370 27 to to IN cord-023095-4dannjjm 1370 28 other other JJ cord-023095-4dannjjm 1370 29 species specie NNS cord-023095-4dannjjm 1370 30 , , , cord-023095-4dannjjm 1370 31 it -PRON- PRP cord-023095-4dannjjm 1370 32 may may MD cord-023095-4dannjjm 1370 33 not not RB cord-023095-4dannjjm 1370 34 modify modify VB cord-023095-4dannjjm 1370 35 insulin insulin NN cord-023095-4dannjjm 1370 36 response response NN cord-023095-4dannjjm 1370 37 . . . cord-023095-4dannjjm 1371 1 Equine equine JJ cord-023095-4dannjjm 1371 2 Gastric gastric JJ cord-023095-4dannjjm 1371 3 Ulcer ulcer NN cord-023095-4dannjjm 1371 4 Syndrome syndrome NN cord-023095-4dannjjm 1371 5 ( ( -LRB- cord-023095-4dannjjm 1371 6 EGUS EGUS NNP cord-023095-4dannjjm 1371 7 ) ) -RRB- cord-023095-4dannjjm 1371 8 is be VBZ cord-023095-4dannjjm 1371 9 a a DT cord-023095-4dannjjm 1371 10 common common JJ cord-023095-4dannjjm 1371 11 medical medical JJ cord-023095-4dannjjm 1371 12 problem problem NN cord-023095-4dannjjm 1371 13 in in IN cord-023095-4dannjjm 1371 14 horses horse NNS cord-023095-4dannjjm 1371 15 . . . cord-023095-4dannjjm 1372 1 The the DT cord-023095-4dannjjm 1372 2 high high JJ cord-023095-4dannjjm 1372 3 prevalence prevalence NN cord-023095-4dannjjm 1372 4 of of IN cord-023095-4dannjjm 1372 5 gastric gastric JJ cord-023095-4dannjjm 1372 6 ulcers ulcer NNS cord-023095-4dannjjm 1372 7 , , , cord-023095-4dannjjm 1372 8 vague vague JJ cord-023095-4dannjjm 1372 9 clinical clinical JJ cord-023095-4dannjjm 1372 10 signs sign NNS cord-023095-4dannjjm 1372 11 and and CC cord-023095-4dannjjm 1372 12 negative negative JJ cord-023095-4dannjjm 1372 13 effect effect NN cord-023095-4dannjjm 1372 14 on on IN cord-023095-4dannjjm 1372 15 performance performance NN cord-023095-4dannjjm 1372 16 make make VBP cord-023095-4dannjjm 1372 17 it -PRON- PRP cord-023095-4dannjjm 1372 18 a a DT cord-023095-4dannjjm 1372 19 significant significant JJ cord-023095-4dannjjm 1372 20 clinical clinical JJ cord-023095-4dannjjm 1372 21 and and CC cord-023095-4dannjjm 1372 22 economic economic JJ cord-023095-4dannjjm 1372 23 problem problem NN cord-023095-4dannjjm 1372 24 within within IN cord-023095-4dannjjm 1372 25 the the DT cord-023095-4dannjjm 1372 26 horse horse NN cord-023095-4dannjjm 1372 27 industry industry NN cord-023095-4dannjjm 1372 28 . . . cord-023095-4dannjjm 1373 1 Current current JJ cord-023095-4dannjjm 1373 2 pharmaceutical pharmaceutical JJ cord-023095-4dannjjm 1373 3 treatments treatment NNS cord-023095-4dannjjm 1373 4 are be VBP cord-023095-4dannjjm 1373 5 expensive expensive JJ cord-023095-4dannjjm 1373 6 and and CC cord-023095-4dannjjm 1373 7 alter alter VB cord-023095-4dannjjm 1373 8 the the DT cord-023095-4dannjjm 1373 9 acidic acidic JJ cord-023095-4dannjjm 1373 10 environment environment NN cord-023095-4dannjjm 1373 11 of of IN cord-023095-4dannjjm 1373 12 the the DT cord-023095-4dannjjm 1373 13 stomach stomach NN cord-023095-4dannjjm 1373 14 . . . cord-023095-4dannjjm 1374 1 Berries berry NNS cord-023095-4dannjjm 1374 2 and and CC cord-023095-4dannjjm 1374 3 pulp pulp NN cord-023095-4dannjjm 1374 4 from from IN cord-023095-4dannjjm 1374 5 the the DT cord-023095-4dannjjm 1374 6 seabuckthorn seabuckthorn JJ cord-023095-4dannjjm 1374 7 plant plant NN cord-023095-4dannjjm 1374 8 ( ( -LRB- cord-023095-4dannjjm 1374 9 Hippophae Hippophae NNP cord-023095-4dannjjm 1374 10 rhamnoides rhamnoides NNP cord-023095-4dannjjm 1374 11 ) ) -RRB- cord-023095-4dannjjm 1374 12 are be VBP cord-023095-4dannjjm 1374 13 a a DT cord-023095-4dannjjm 1374 14 rich rich JJ cord-023095-4dannjjm 1374 15 source source NN cord-023095-4dannjjm 1374 16 of of IN cord-023095-4dannjjm 1374 17 vitamins vitamin NNS cord-023095-4dannjjm 1374 18 , , , cord-023095-4dannjjm 1374 19 trace trace NN cord-023095-4dannjjm 1374 20 minerals mineral NNS cord-023095-4dannjjm 1374 21 , , , cord-023095-4dannjjm 1374 22 amino amino JJ cord-023095-4dannjjm 1374 23 acids acid NNS cord-023095-4dannjjm 1374 24 , , , cord-023095-4dannjjm 1374 25 antioxidants antioxidant NNS cord-023095-4dannjjm 1374 26 , , , cord-023095-4dannjjm 1374 27 and and CC cord-023095-4dannjjm 1374 28 other other JJ cord-023095-4dannjjm 1374 29 bioactive bioactive JJ cord-023095-4dannjjm 1374 30 substances substance NNS cord-023095-4dannjjm 1374 31 and and CC cord-023095-4dannjjm 1374 32 have have VBP cord-023095-4dannjjm 1374 33 been be VBN cord-023095-4dannjjm 1374 34 used use VBN cord-023095-4dannjjm 1374 35 successfully successfully RB cord-023095-4dannjjm 1374 36 to to TO cord-023095-4dannjjm 1374 37 treat treat VB cord-023095-4dannjjm 1374 38 stomach stomach NN cord-023095-4dannjjm 1374 39 ulcers ulcer NNS cord-023095-4dannjjm 1374 40 in in IN cord-023095-4dannjjm 1374 41 man man NN cord-023095-4dannjjm 1374 42 and and CC cord-023095-4dannjjm 1374 43 rats rat NNS cord-023095-4dannjjm 1374 44 . . . cord-023095-4dannjjm 1375 1 The the DT cord-023095-4dannjjm 1375 2 purpose purpose NN cord-023095-4dannjjm 1375 3 of of IN cord-023095-4dannjjm 1375 4 this this DT cord-023095-4dannjjm 1375 5 study study NN cord-023095-4dannjjm 1375 6 was be VBD cord-023095-4dannjjm 1375 7 to to TO cord-023095-4dannjjm 1375 8 evaluate evaluate VB cord-023095-4dannjjm 1375 9 the the DT cord-023095-4dannjjm 1375 10 efficacy efficacy NN cord-023095-4dannjjm 1375 11 of of IN cord-023095-4dannjjm 1375 12 a a DT cord-023095-4dannjjm 1375 13 commercially commercially RB cord-023095-4dannjjm 1375 14 sold sell VBN cord-023095-4dannjjm 1375 15 , , , cord-023095-4dannjjm 1375 16 liquid liquid JJ cord-023095-4dannjjm 1375 17 extract extract NN cord-023095-4dannjjm 1375 18 of of IN cord-023095-4dannjjm 1375 19 seabuckthorn seabuckthorn JJ cord-023095-4dannjjm 1375 20 berries berry NNS cord-023095-4dannjjm 1376 1 ( ( -LRB- cord-023095-4dannjjm 1376 2 SeaBuck SeaBuck NNP cord-023095-4dannjjm 1376 3 TM TM NNP cord-023095-4dannjjm 1376 4 SBT SBT NNP cord-023095-4dannjjm 1376 5 Gastro Gastro NNP cord-023095-4dannjjm 1376 6 - - HYPH cord-023095-4dannjjm 1376 7 Plus Plus NNP cord-023095-4dannjjm 1376 8 ) ) -RRB- cord-023095-4dannjjm 1376 9 for for IN cord-023095-4dannjjm 1376 10 treatment treatment NN cord-023095-4dannjjm 1376 11 and and CC cord-023095-4dannjjm 1376 12 prevention prevention NN cord-023095-4dannjjm 1376 13 of of IN cord-023095-4dannjjm 1376 14 gastric gastric JJ cord-023095-4dannjjm 1376 15 ulcers ulcer NNS cord-023095-4dannjjm 1376 16 in in IN cord-023095-4dannjjm 1376 17 horses horse NNS cord-023095-4dannjjm 1376 18 . . . cord-023095-4dannjjm 1377 1 Eight eight CD cord-023095-4dannjjm 1377 2 Thoroughbred Thoroughbred NNP cord-023095-4dannjjm 1377 3 and and CC cord-023095-4dannjjm 1377 4 Thoroughbred Thoroughbred NNP cord-023095-4dannjjm 1377 5 - - HYPH cord-023095-4dannjjm 1377 6 cross cross NN cord-023095-4dannjjm 1377 7 horses horse NNS cord-023095-4dannjjm 1377 8 ( ( -LRB- cord-023095-4dannjjm 1377 9 3 3 CD cord-023095-4dannjjm 1377 10 - - SYM cord-023095-4dannjjm 1377 11 10 10 CD cord-023095-4dannjjm 1377 12 years year NNS cord-023095-4dannjjm 1377 13 of of IN cord-023095-4dannjjm 1377 14 age age NN cord-023095-4dannjjm 1377 15 , , , cord-023095-4dannjjm 1377 16 5 5 CD cord-023095-4dannjjm 1377 17 geldings gelding NNS cord-023095-4dannjjm 1377 18 & & CC cord-023095-4dannjjm 1377 19 3 3 CD cord-023095-4dannjjm 1377 20 mares mare NNS cord-023095-4dannjjm 1377 21 , , , cord-023095-4dannjjm 1377 22 380 380 CD cord-023095-4dannjjm 1377 23 - - SYM cord-023095-4dannjjm 1377 24 600 600 CD cord-023095-4dannjjm 1377 25 kg kg NNS cord-023095-4dannjjm 1377 26 ) ) -RRB- cord-023095-4dannjjm 1377 27 were be VBD cord-023095-4dannjjm 1377 28 used use VBN cord-023095-4dannjjm 1377 29 in in IN cord-023095-4dannjjm 1377 30 a a DT cord-023095-4dannjjm 1377 31 blinded blinded JJ cord-023095-4dannjjm 1377 32 two two CD cord-023095-4dannjjm 1377 33 - - HYPH cord-023095-4dannjjm 1377 34 period period NN cord-023095-4dannjjm 1377 35 cross cross NN cord-023095-4dannjjm 1377 36 - - HYPH cord-023095-4dannjjm 1377 37 over over RP cord-023095-4dannjjm 1377 38 study study NN cord-023095-4dannjjm 1377 39 . . . cord-023095-4dannjjm 1378 1 Treatments treatment NNS cord-023095-4dannjjm 1378 2 consisted consist VBN cord-023095-4dannjjm 1378 3 of of IN cord-023095-4dannjjm 1378 4 control control NN cord-023095-4dannjjm 1378 5 ( ( -LRB- cord-023095-4dannjjm 1378 6 untreated untreated JJ cord-023095-4dannjjm 1378 7 ) ) -RRB- cord-023095-4dannjjm 1378 8 and and CC cord-023095-4dannjjm 1378 9 treatment treatment NN cord-023095-4dannjjm 1379 1 ( ( -LRB- cord-023095-4dannjjm 1379 2 SeaBuck SeaBuck NNP cord-023095-4dannjjm 1379 3 TM TM NNP cord-023095-4dannjjm 1379 4 SBT SBT NNP cord-023095-4dannjjm 1379 5 Gastro Gastro NNP cord-023095-4dannjjm 1379 6 - - HYPH cord-023095-4dannjjm 1379 7 Plus Plus NNP cord-023095-4dannjjm 1379 8 ) ) -RRB- cord-023095-4dannjjm 1379 9 twice twice RB cord-023095-4dannjjm 1379 10 daily daily RB cord-023095-4dannjjm 1379 11 mixed mix VBN cord-023095-4dannjjm 1379 12 with with IN cord-023095-4dannjjm 1379 13 the the DT cord-023095-4dannjjm 1379 14 grain grain NN cord-023095-4dannjjm 1379 15 meal meal NN cord-023095-4dannjjm 1379 16 . . . cord-023095-4dannjjm 1380 1 Horses horse NNS cord-023095-4dannjjm 1380 2 were be VBD cord-023095-4dannjjm 1380 3 treated treat VBN cord-023095-4dannjjm 1380 4 for for IN cord-023095-4dannjjm 1380 5 5 5 CD cord-023095-4dannjjm 1380 6 weeks week NNS cord-023095-4dannjjm 1380 7 followed follow VBN cord-023095-4dannjjm 1380 8 by by IN cord-023095-4dannjjm 1380 9 a a DT cord-023095-4dannjjm 1380 10 1 1 CD cord-023095-4dannjjm 1380 11 week week NN cord-023095-4dannjjm 1380 12 alternating alternate VBG cord-023095-4dannjjm 1380 13 feed feed NN cord-023095-4dannjjm 1380 14 - - HYPH cord-023095-4dannjjm 1380 15 deprivation deprivation NN cord-023095-4dannjjm 1380 16 period period NN cord-023095-4dannjjm 1380 17 to to TO cord-023095-4dannjjm 1380 18 induce induce VB cord-023095-4dannjjm 1380 19 or or CC cord-023095-4dannjjm 1380 20 worsen worsen VB cord-023095-4dannjjm 1380 21 existing exist VBG cord-023095-4dannjjm 1380 22 ulcers ulcer NNS cord-023095-4dannjjm 1380 23 . . . cord-023095-4dannjjm 1381 1 Gastroscopies gastroscopy NNS cord-023095-4dannjjm 1381 2 were be VBD cord-023095-4dannjjm 1381 3 performed perform VBN cord-023095-4dannjjm 1381 4 on on IN cord-023095-4dannjjm 1381 5 all all DT cord-023095-4dannjjm 1381 6 horses horse NNS cord-023095-4dannjjm 1381 7 on on IN cord-023095-4dannjjm 1381 8 day day NN cord-023095-4dannjjm 1381 9 0 0 CD cord-023095-4dannjjm 1381 10 , , , cord-023095-4dannjjm 1381 11 week week NN cord-023095-4dannjjm 1381 12 5 5 CD cord-023095-4dannjjm 1381 13 , , , cord-023095-4dannjjm 1381 14 and and CC cord-023095-4dannjjm 1381 15 week week NN cord-023095-4dannjjm 1381 16 6 6 CD cord-023095-4dannjjm 1381 17 ( ( -LRB- cord-023095-4dannjjm 1381 18 at at IN cord-023095-4dannjjm 1381 19 the the DT cord-023095-4dannjjm 1381 20 end end NN cord-023095-4dannjjm 1381 21 of of IN cord-023095-4dannjjm 1381 22 the the DT cord-023095-4dannjjm 1381 23 alternating alternate VBG cord-023095-4dannjjm 1381 24 feed feed NN cord-023095-4dannjjm 1381 25 - - HYPH cord-023095-4dannjjm 1381 26 deprivation deprivation NN cord-023095-4dannjjm 1381 27 period period NN cord-023095-4dannjjm 1381 28 ) ) -RRB- cord-023095-4dannjjm 1381 29 . . . cord-023095-4dannjjm 1382 1 Gastric gastric JJ cord-023095-4dannjjm 1382 2 juice juice NN cord-023095-4dannjjm 1382 3 was be VBD cord-023095-4dannjjm 1382 4 aspirated aspirate VBN cord-023095-4dannjjm 1382 5 and and CC cord-023095-4dannjjm 1382 6 pH pH NNP cord-023095-4dannjjm 1382 7 was be VBD cord-023095-4dannjjm 1382 8 measured measure VBN cord-023095-4dannjjm 1382 9 . . . cord-023095-4dannjjm 1383 1 During during IN cord-023095-4dannjjm 1383 2 gastroscopy gastroscopy NN cord-023095-4dannjjm 1383 3 , , , cord-023095-4dannjjm 1383 4 gastric gastric JJ cord-023095-4dannjjm 1383 5 ulcer ulcer NN cord-023095-4dannjjm 1383 6 scores score NNS cord-023095-4dannjjm 1383 7 were be VBD cord-023095-4dannjjm 1383 8 assigned assign VBN cord-023095-4dannjjm 1383 9 to to IN cord-023095-4dannjjm 1383 10 each each DT cord-023095-4dannjjm 1383 11 stomach stomach NN cord-023095-4dannjjm 1383 12 based base VBN cord-023095-4dannjjm 1383 13 on on IN cord-023095-4dannjjm 1383 14 lesion lesion NN cord-023095-4dannjjm 1383 15 number number NN cord-023095-4dannjjm 1383 16 and and CC cord-023095-4dannjjm 1383 17 severity severity NN cord-023095-4dannjjm 1383 18 . . . cord-023095-4dannjjm 1384 1 Horses horse NNS cord-023095-4dannjjm 1384 2 acted act VBD cord-023095-4dannjjm 1384 3 as as IN cord-023095-4dannjjm 1384 4 their -PRON- PRP$ cord-023095-4dannjjm 1384 5 own own JJ cord-023095-4dannjjm 1384 6 controls control NNS cord-023095-4dannjjm 1384 7 , , , cord-023095-4dannjjm 1384 8 and and CC cord-023095-4dannjjm 1384 9 between between IN cord-023095-4dannjjm 1384 10 each each DT cord-023095-4dannjjm 1384 11 treatment treatment NN cord-023095-4dannjjm 1384 12 period period NN cord-023095-4dannjjm 1384 13 the the DT cord-023095-4dannjjm 1384 14 horses horse NNS cord-023095-4dannjjm 1384 15 had have VBD cord-023095-4dannjjm 1384 16 a a DT cord-023095-4dannjjm 1384 17 2-week 2-week CD cord-023095-4dannjjm 1384 18 washout washout NN cord-023095-4dannjjm 1384 19 period period NN cord-023095-4dannjjm 1384 20 . . . cord-023095-4dannjjm 1385 1 Data datum NNS cord-023095-4dannjjm 1385 2 was be VBD cord-023095-4dannjjm 1385 3 analyzed analyze VBN cord-023095-4dannjjm 1385 4 by by IN cord-023095-4dannjjm 1385 5 ANOVA ANOVA NNP cord-023095-4dannjjm 1385 6 for for IN cord-023095-4dannjjm 1385 7 repeated repeat VBN cord-023095-4dannjjm 1385 8 measures measure NNS cord-023095-4dannjjm 1385 9 via via IN cord-023095-4dannjjm 1385 10 the the DT cord-023095-4dannjjm 1385 11 GLM GLM NNP cord-023095-4dannjjm 1385 12 procedure procedure NN cord-023095-4dannjjm 1385 13 ( ( -LRB- cord-023095-4dannjjm 1385 14 SAS SAS NNP cord-023095-4dannjjm 1385 15 Inst Inst NNP cord-023095-4dannjjm 1385 16 . . . cord-023095-4dannjjm 1385 17 Inc. Inc. NNP cord-023095-4dannjjm 1385 18 , , , cord-023095-4dannjjm 1385 19 Cary Cary NNP cord-023095-4dannjjm 1385 20 , , , cord-023095-4dannjjm 1385 21 NC NC NNP cord-023095-4dannjjm 1385 22 ) ) -RRB- cord-023095-4dannjjm 1385 23 . . . cord-023095-4dannjjm 1386 1 When when WRB cord-023095-4dannjjm 1386 2 significant significant JJ cord-023095-4dannjjm 1386 3 differences difference NNS cord-023095-4dannjjm 1386 4 ( ( -LRB- cord-023095-4dannjjm 1386 5 P p NN cord-023095-4dannjjm 1386 6 o o NN cord-023095-4dannjjm 1386 7 0.05 0.05 CD cord-023095-4dannjjm 1386 8 ) ) -RRB- cord-023095-4dannjjm 1386 9 were be VBD cord-023095-4dannjjm 1386 10 observed observe VBN cord-023095-4dannjjm 1386 11 , , , cord-023095-4dannjjm 1386 12 a a DT cord-023095-4dannjjm 1386 13 post post JJ cord-023095-4dannjjm 1386 14 - - JJ cord-023095-4dannjjm 1386 15 hoc hoc FW cord-023095-4dannjjm 1386 16 Tukey Tukey NNP cord-023095-4dannjjm 1386 17 's 's POS cord-023095-4dannjjm 1386 18 test test NN cord-023095-4dannjjm 1386 19 was be VBD cord-023095-4dannjjm 1386 20 used use VBN cord-023095-4dannjjm 1386 21 to to TO cord-023095-4dannjjm 1386 22 determine determine VB cord-023095-4dannjjm 1386 23 differences difference NNS cord-023095-4dannjjm 1386 24 . . . cord-023095-4dannjjm 1387 1 Non non JJ cord-023095-4dannjjm 1387 2 - - JJ cord-023095-4dannjjm 1387 3 glandular glandular JJ cord-023095-4dannjjm 1387 4 gastric gastric JJ cord-023095-4dannjjm 1387 5 ulcer ulcer NN cord-023095-4dannjjm 1387 6 scores score NNS cord-023095-4dannjjm 1387 7 significantly significantly RB cord-023095-4dannjjm 1387 8 increased increase VBD cord-023095-4dannjjm 1387 9 in in IN cord-023095-4dannjjm 1387 10 all all DT cord-023095-4dannjjm 1387 11 control control NN cord-023095-4dannjjm 1387 12 and and CC cord-023095-4dannjjm 1387 13 SBT SBT NNP cord-023095-4dannjjm 1387 14 - - HYPH cord-023095-4dannjjm 1387 15 treated treat VBN cord-023095-4dannjjm 1387 16 horses horse NNS cord-023095-4dannjjm 1387 17 from from IN cord-023095-4dannjjm 1387 18 Week week NN cord-023095-4dannjjm 1387 19 5 5 CD cord-023095-4dannjjm 1387 20 to to IN cord-023095-4dannjjm 1387 21 Week week NN cord-023095-4dannjjm 1387 22 6 6 CD cord-023095-4dannjjm 1387 23 , , , cord-023095-4dannjjm 1387 24 after after IN cord-023095-4dannjjm 1387 25 the the DT cord-023095-4dannjjm 1387 26 feed feed NN cord-023095-4dannjjm 1387 27 - - HYPH cord-023095-4dannjjm 1387 28 deprivation deprivation NN cord-023095-4dannjjm 1387 29 phase phase NN cord-023095-4dannjjm 1387 30 of of IN cord-023095-4dannjjm 1387 31 the the DT cord-023095-4dannjjm 1387 32 study study NN cord-023095-4dannjjm 1387 33 . . . cord-023095-4dannjjm 1388 1 There there EX cord-023095-4dannjjm 1388 2 was be VBD cord-023095-4dannjjm 1388 3 no no DT cord-023095-4dannjjm 1388 4 significant significant JJ cord-023095-4dannjjm 1388 5 difference difference NN cord-023095-4dannjjm 1388 6 in in IN cord-023095-4dannjjm 1388 7 the the DT cord-023095-4dannjjm 1388 8 non non JJ cord-023095-4dannjjm 1388 9 - - JJ cord-023095-4dannjjm 1388 10 glandular glandular JJ cord-023095-4dannjjm 1388 11 gastric gastric JJ cord-023095-4dannjjm 1388 12 number number NN cord-023095-4dannjjm 1388 13 ( ( -LRB- cord-023095-4dannjjm 1388 14 P p NN cord-023095-4dannjjm 1388 15 5 5 CD cord-023095-4dannjjm 1388 16 0.84 0.84 CD cord-023095-4dannjjm 1388 17 ) ) -RRB- cord-023095-4dannjjm 1388 18 and and CC cord-023095-4dannjjm 1388 19 nonglandular nonglandular JJ cord-023095-4dannjjm 1388 20 gastric gastric JJ cord-023095-4dannjjm 1388 21 severity severity NN cord-023095-4dannjjm 1388 22 ( ( -LRB- cord-023095-4dannjjm 1388 23 P p NN cord-023095-4dannjjm 1388 24 5 5 CD cord-023095-4dannjjm 1388 25 0.51 0.51 CD cord-023095-4dannjjm 1388 26 ) ) -RRB- cord-023095-4dannjjm 1388 27 scores score NNS cord-023095-4dannjjm 1388 28 in in IN cord-023095-4dannjjm 1388 29 SBT SBT NNP cord-023095-4dannjjm 1388 30 - - HYPH cord-023095-4dannjjm 1388 31 treated treat VBN cord-023095-4dannjjm 1388 32 horses horse NNS cord-023095-4dannjjm 1388 33 compared compare VBN cord-023095-4dannjjm 1388 34 to to IN cord-023095-4dannjjm 1388 35 non non JJ cord-023095-4dannjjm 1388 36 - - JJ cord-023095-4dannjjm 1388 37 treated treat VBN cord-023095-4dannjjm 1388 38 controls control NNS cord-023095-4dannjjm 1388 39 . . . cord-023095-4dannjjm 1389 1 Glandular glandular JJ cord-023095-4dannjjm 1389 2 ulcer ulcer NN cord-023095-4dannjjm 1389 3 number number NN cord-023095-4dannjjm 1389 4 ( ( -LRB- cord-023095-4dannjjm 1389 5 P p NN cord-023095-4dannjjm 1389 6 5 5 CD cord-023095-4dannjjm 1389 7 0.02 0.02 CD cord-023095-4dannjjm 1389 8 ) ) -RRB- cord-023095-4dannjjm 1389 9 and and CC cord-023095-4dannjjm 1389 10 glandular glandular JJ cord-023095-4dannjjm 1389 11 ulcer ulcer NN cord-023095-4dannjjm 1389 12 severity severity NN cord-023095-4dannjjm 1389 13 ( ( -LRB- cord-023095-4dannjjm 1389 14 P p NN cord-023095-4dannjjm 1389 15 5 5 CD cord-023095-4dannjjm 1389 16 0.02 0.02 CD cord-023095-4dannjjm 1389 17 ) ) -RRB- cord-023095-4dannjjm 1389 18 was be VBD cord-023095-4dannjjm 1389 19 significantly significantly RB cord-023095-4dannjjm 1389 20 lower low JJR cord-023095-4dannjjm 1389 21 in in IN cord-023095-4dannjjm 1389 22 the the DT cord-023095-4dannjjm 1389 23 SBT SBT NNP cord-023095-4dannjjm 1389 24 - - HYPH cord-023095-4dannjjm 1389 25 treated treat VBN cord-023095-4dannjjm 1389 26 horses horse NNS cord-023095-4dannjjm 1389 27 compared compare VBN cord-023095-4dannjjm 1389 28 to to IN cord-023095-4dannjjm 1389 29 the the DT cord-023095-4dannjjm 1389 30 control control NN cord-023095-4dannjjm 1389 31 horses horse NNS cord-023095-4dannjjm 1389 32 . . . cord-023095-4dannjjm 1390 1 There there EX cord-023095-4dannjjm 1390 2 was be VBD cord-023095-4dannjjm 1390 3 no no DT cord-023095-4dannjjm 1390 4 significant significant JJ cord-023095-4dannjjm 1390 5 difference difference NN cord-023095-4dannjjm 1390 6 in in IN cord-023095-4dannjjm 1390 7 the the DT cord-023095-4dannjjm 1390 8 pH ph NN cord-023095-4dannjjm 1391 1 ( ( -LRB- cord-023095-4dannjjm 1391 2 P p NN cord-023095-4dannjjm 1391 3 5 5 CD cord-023095-4dannjjm 1391 4 0.06 0.06 CD cord-023095-4dannjjm 1391 5 ) ) -RRB- cord-023095-4dannjjm 1391 6 in in IN cord-023095-4dannjjm 1391 7 SBT SBT NNP cord-023095-4dannjjm 1391 8 - - HYPH cord-023095-4dannjjm 1391 9 treated treat VBN cord-023095-4dannjjm 1391 10 horses horse NNS cord-023095-4dannjjm 1391 11 compared compare VBN cord-023095-4dannjjm 1391 12 to to IN cord-023095-4dannjjm 1391 13 non non JJ cord-023095-4dannjjm 1391 14 - - JJ cord-023095-4dannjjm 1391 15 treated treat VBN cord-023095-4dannjjm 1391 16 controls control NNS cord-023095-4dannjjm 1391 17 . . . cord-023095-4dannjjm 1392 1 Thus thus RB cord-023095-4dannjjm 1392 2 , , , cord-023095-4dannjjm 1392 3 SeaBuck SeaBuck NNP cord-023095-4dannjjm 1392 4 TM TM NNP cord-023095-4dannjjm 1392 5 SBT SBT NNP cord-023095-4dannjjm 1392 6 Gastro Gastro NNP cord-023095-4dannjjm 1392 7 - - HYPH cord-023095-4dannjjm 1392 8 Plus Plus NNP cord-023095-4dannjjm 1392 9 , , , cord-023095-4dannjjm 1392 10 mixed mixed JJ cord-023095-4dannjjm 1392 11 in in IN cord-023095-4dannjjm 1392 12 the the DT cord-023095-4dannjjm 1392 13 feed feed NN cord-023095-4dannjjm 1392 14 twice twice RB cord-023095-4dannjjm 1392 15 daily daily RB cord-023095-4dannjjm 1392 16 , , , cord-023095-4dannjjm 1392 17 may may MD cord-023095-4dannjjm 1392 18 be be VB cord-023095-4dannjjm 1392 19 efficacious efficacious JJ cord-023095-4dannjjm 1392 20 in in IN cord-023095-4dannjjm 1392 21 controlling control VBG cord-023095-4dannjjm 1392 22 the the DT cord-023095-4dannjjm 1392 23 severity severity NN cord-023095-4dannjjm 1392 24 of of IN cord-023095-4dannjjm 1392 25 glandular glandular JJ cord-023095-4dannjjm 1392 26 ulcers ulcer NNS cord-023095-4dannjjm 1392 27 in in IN cord-023095-4dannjjm 1392 28 horses horse NNS cord-023095-4dannjjm 1392 29 during during IN cord-023095-4dannjjm 1392 30 stress stress NN cord-023095-4dannjjm 1392 31 , , , cord-023095-4dannjjm 1392 32 without without IN cord-023095-4dannjjm 1392 33 increasing increase VBG cord-023095-4dannjjm 1392 34 stomach stomach NN cord-023095-4dannjjm 1392 35 pH. ph. NN cord-023095-4dannjjm 1393 1 The the DT cord-023095-4dannjjm 1393 2 availability availability NN cord-023095-4dannjjm 1393 3 of of IN cord-023095-4dannjjm 1393 4 rapid rapid JJ cord-023095-4dannjjm 1393 5 and and CC cord-023095-4dannjjm 1393 6 accurate accurate JJ cord-023095-4dannjjm 1393 7 quantitative quantitative JJ cord-023095-4dannjjm 1393 8 fibrinogen fibrinogen NN cord-023095-4dannjjm 1393 9 measurements measurement NNS cord-023095-4dannjjm 1393 10 may may MD cord-023095-4dannjjm 1393 11 be be VB cord-023095-4dannjjm 1393 12 useful useful JJ cord-023095-4dannjjm 1393 13 for for IN cord-023095-4dannjjm 1393 14 evaluation evaluation NN cord-023095-4dannjjm 1393 15 of of IN cord-023095-4dannjjm 1393 16 hospitalized hospitalize VBN cord-023095-4dannjjm 1393 17 equine equine JJ cord-023095-4dannjjm 1393 18 patients patient NNS cord-023095-4dannjjm 1393 19 . . . cord-023095-4dannjjm 1394 1 The the DT cord-023095-4dannjjm 1394 2 Abaxis Abaxis NNP cord-023095-4dannjjm 1394 3 VSPro vspro NN cord-023095-4dannjjm 1394 4 analyzer analyzer NN cord-023095-4dannjjm 1394 5 was be VBD cord-023095-4dannjjm 1394 6 evaluated evaluate VBN cord-023095-4dannjjm 1394 7 for for IN cord-023095-4dannjjm 1394 8 precision precision NN cord-023095-4dannjjm 1394 9 using use VBG cord-023095-4dannjjm 1394 10 two two CD cord-023095-4dannjjm 1394 11 levels level NNS cord-023095-4dannjjm 1394 12 of of IN cord-023095-4dannjjm 1394 13 human human JJ cord-023095-4dannjjm 1394 14 fibrinogen fibrinogen NN cord-023095-4dannjjm 1394 15 controls control NNS cord-023095-4dannjjm 1394 16 ( ( -LRB- cord-023095-4dannjjm 1394 17 300 300 CD cord-023095-4dannjjm 1394 18 mg mg NNP cord-023095-4dannjjm 1394 19 / / SYM cord-023095-4dannjjm 1394 20 dL dl NN cord-023095-4dannjjm 1394 21 and and CC cord-023095-4dannjjm 1394 22 150 150 CD cord-023095-4dannjjm 1394 23 mg mg NNP cord-023095-4dannjjm 1394 24 / / SYM cord-023095-4dannjjm 1394 25 dL dl NN cord-023095-4dannjjm 1394 26 ) ) -RRB- cord-023095-4dannjjm 1394 27 , , , cord-023095-4dannjjm 1394 28 four four CD cord-023095-4dannjjm 1394 29 different different JJ cord-023095-4dannjjm 1394 30 VSPro vspro NN cord-023095-4dannjjm 1394 31 machines machine NNS cord-023095-4dannjjm 1394 32 , , , cord-023095-4dannjjm 1394 33 and and CC cord-023095-4dannjjm 1394 34 two two CD cord-023095-4dannjjm 1394 35 different different JJ cord-023095-4dannjjm 1394 36 lots lot NNS cord-023095-4dannjjm 1394 37 of of IN cord-023095-4dannjjm 1394 38 cartridges cartridge NNS cord-023095-4dannjjm 1394 39 , , , cord-023095-4dannjjm 1394 40 assessed assess VBN cord-023095-4dannjjm 1394 41 over over IN cord-023095-4dannjjm 1394 42 5 5 CD cord-023095-4dannjjm 1394 43 subsequent subsequent JJ cord-023095-4dannjjm 1394 44 days day NNS cord-023095-4dannjjm 1394 45 . . . cord-023095-4dannjjm 1395 1 The the DT cord-023095-4dannjjm 1395 2 coefficients coefficient NNS cord-023095-4dannjjm 1395 3 of of IN cord-023095-4dannjjm 1395 4 variation variation NN cord-023095-4dannjjm 1395 5 of of IN cord-023095-4dannjjm 1395 6 the the DT cord-023095-4dannjjm 1395 7 assay assay NN cord-023095-4dannjjm 1395 8 ranged range VBD cord-023095-4dannjjm 1395 9 from from IN cord-023095-4dannjjm 1395 10 4 4 CD cord-023095-4dannjjm 1395 11 % % NN cord-023095-4dannjjm 1395 12 ( ( -LRB- cord-023095-4dannjjm 1395 13 300 300 CD cord-023095-4dannjjm 1395 14 mg mg NNP cord-023095-4dannjjm 1395 15 / / SYM cord-023095-4dannjjm 1395 16 dL dl NN cord-023095-4dannjjm 1395 17 ) ) -RRB- cord-023095-4dannjjm 1395 18 to to IN cord-023095-4dannjjm 1395 19 8 8 CD cord-023095-4dannjjm 1395 20 % % NN cord-023095-4dannjjm 1395 21 ( ( -LRB- cord-023095-4dannjjm 1395 22 150 150 CD cord-023095-4dannjjm 1395 23 mg/ mg/ NN cord-023095-4dannjjm 1395 24 dL dl NN cord-023095-4dannjjm 1395 25 ) ) -RRB- cord-023095-4dannjjm 1395 26 . . . cord-023095-4dannjjm 1396 1 We -PRON- PRP cord-023095-4dannjjm 1396 2 subsequently subsequently RB cord-023095-4dannjjm 1396 3 evaluated evaluate VBD cord-023095-4dannjjm 1396 4 the the DT cord-023095-4dannjjm 1396 5 Abaxis Abaxis NNP cord-023095-4dannjjm 1396 6 VSPro VSPro VBN cord-023095-4dannjjm 1396 7 fibrinogen fibrinogen NN cord-023095-4dannjjm 1396 8 assay assay NN cord-023095-4dannjjm 1396 9 compared compare VBN cord-023095-4dannjjm 1396 10 to to IN cord-023095-4dannjjm 1396 11 fibrinogen fibrinogen NN cord-023095-4dannjjm 1396 12 concentration concentration NN cord-023095-4dannjjm 1396 13 measured measure VBN cord-023095-4dannjjm 1396 14 using use VBG cord-023095-4dannjjm 1396 15 the the DT cord-023095-4dannjjm 1396 16 Beckman Beckman NNP cord-023095-4dannjjm 1396 17 Coulter Coulter NNP cord-023095-4dannjjm 1396 18 ACL-1000 ACL-1000 NNP cord-023095-4dannjjm 1396 19 in in IN cord-023095-4dannjjm 1396 20 50 50 CD cord-023095-4dannjjm 1396 21 equine equine JJ cord-023095-4dannjjm 1396 22 samples sample NNS cord-023095-4dannjjm 1396 23 of of IN cord-023095-4dannjjm 1396 24 varying vary VBG cord-023095-4dannjjm 1396 25 fibrinogen fibrinogen NN cord-023095-4dannjjm 1396 26 concentrations concentration NNS cord-023095-4dannjjm 1396 27 obtained obtain VBN cord-023095-4dannjjm 1396 28 from from IN cord-023095-4dannjjm 1396 29 horses horse NNS cord-023095-4dannjjm 1396 30 with with IN cord-023095-4dannjjm 1396 31 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1396 32 disease disease NN cord-023095-4dannjjm 1396 33 . . . cord-023095-4dannjjm 1397 1 All all DT cord-023095-4dannjjm 1397 2 samples sample NNS cord-023095-4dannjjm 1397 3 were be VBD cord-023095-4dannjjm 1397 4 measured measure VBN cord-023095-4dannjjm 1397 5 in in IN cord-023095-4dannjjm 1397 6 citrated citrated JJ cord-023095-4dannjjm 1397 7 plasma plasma NN cord-023095-4dannjjm 1397 8 . . . cord-023095-4dannjjm 1398 1 Fibrinogen fibrinogen NN cord-023095-4dannjjm 1398 2 samples sample NNS cord-023095-4dannjjm 1398 3 measured measure VBN cord-023095-4dannjjm 1398 4 on on IN cord-023095-4dannjjm 1398 5 the the DT cord-023095-4dannjjm 1398 6 ACL-1000 acl-1000 NN cord-023095-4dannjjm 1398 7 ranged range VBD cord-023095-4dannjjm 1398 8 from from IN cord-023095-4dannjjm 1398 9 226 226 CD cord-023095-4dannjjm 1398 10 to to TO cord-023095-4dannjjm 1398 11 959 959 CD cord-023095-4dannjjm 1398 12 mg mg NNP cord-023095-4dannjjm 1398 13 / / SYM cord-023095-4dannjjm 1398 14 dL dl NN cord-023095-4dannjjm 1398 15 ( ( -LRB- cord-023095-4dannjjm 1398 16 median median JJ cord-023095-4dannjjm 1398 17 501 501 CD cord-023095-4dannjjm 1398 18 mg mg NNP cord-023095-4dannjjm 1398 19 / / SYM cord-023095-4dannjjm 1398 20 dL dl NN cord-023095-4dannjjm 1398 21 ) ) -RRB- cord-023095-4dannjjm 1398 22 . . . cord-023095-4dannjjm 1399 1 VSPro vspro JJ cord-023095-4dannjjm 1399 2 samples sample NNS cord-023095-4dannjjm 1399 3 were be VBD cord-023095-4dannjjm 1399 4 run run VBN cord-023095-4dannjjm 1399 5 in in IN cord-023095-4dannjjm 1399 6 duplicate duplicate NN cord-023095-4dannjjm 1399 7 , , , cord-023095-4dannjjm 1399 8 and and CC cord-023095-4dannjjm 1399 9 the the DT cord-023095-4dannjjm 1399 10 mean mean NN cord-023095-4dannjjm 1399 11 compared compare VBN cord-023095-4dannjjm 1399 12 to to IN cord-023095-4dannjjm 1399 13 the the DT cord-023095-4dannjjm 1399 14 ACL ACL NNP cord-023095-4dannjjm 1399 15 values value NNS cord-023095-4dannjjm 1399 16 . . . cord-023095-4dannjjm 1400 1 Pearson Pearson NNP cord-023095-4dannjjm 1400 2 correlation correlation NN cord-023095-4dannjjm 1400 3 coefficient coefficient NN cord-023095-4dannjjm 1400 4 analysis analysis NN cord-023095-4dannjjm 1400 5 generated generate VBD cord-023095-4dannjjm 1400 6 an an DT cord-023095-4dannjjm 1400 7 r r NN cord-023095-4dannjjm 1400 8 value value NN cord-023095-4dannjjm 1400 9 of of IN cord-023095-4dannjjm 1400 10 0.949 0.949 CD cord-023095-4dannjjm 1401 1 ( ( -LRB- cord-023095-4dannjjm 1401 2 P p NN cord-023095-4dannjjm 1401 3 o o NN cord-023095-4dannjjm 1401 4 0.001 0.001 CD cord-023095-4dannjjm 1401 5 ) ) -RRB- cord-023095-4dannjjm 1401 6 . . . cord-023095-4dannjjm 1402 1 Duplicate duplicate JJ cord-023095-4dannjjm 1402 2 measurements measurement NNS cord-023095-4dannjjm 1402 3 on on IN cord-023095-4dannjjm 1402 4 the the DT cord-023095-4dannjjm 1402 5 VSPro vspro NN cord-023095-4dannjjm 1402 6 were be VBD cord-023095-4dannjjm 1402 7 strongly strongly RB cord-023095-4dannjjm 1402 8 correlated correlate VBN cord-023095-4dannjjm 1402 9 to to IN cord-023095-4dannjjm 1402 10 each each DT cord-023095-4dannjjm 1402 11 other other JJ cord-023095-4dannjjm 1402 12 with with IN cord-023095-4dannjjm 1402 13 an an DT cord-023095-4dannjjm 1402 14 r r NN cord-023095-4dannjjm 1402 15 value value NN cord-023095-4dannjjm 1402 16 of of IN cord-023095-4dannjjm 1402 17 0.9690 0.9690 CD cord-023095-4dannjjm 1403 1 ( ( -LRB- cord-023095-4dannjjm 1403 2 P p NN cord-023095-4dannjjm 1403 3 o o NN cord-023095-4dannjjm 1403 4 0.001 0.001 CD cord-023095-4dannjjm 1403 5 ) ) -RRB- cord-023095-4dannjjm 1403 6 . . . cord-023095-4dannjjm 1404 1 Bland Bland NNP cord-023095-4dannjjm 1404 2 - - HYPH cord-023095-4dannjjm 1404 3 Altman Altman NNP cord-023095-4dannjjm 1404 4 analysis analysis NN cord-023095-4dannjjm 1404 5 of of IN cord-023095-4dannjjm 1404 6 these these DT cord-023095-4dannjjm 1404 7 samples sample NNS cord-023095-4dannjjm 1404 8 for for IN cord-023095-4dannjjm 1404 9 the the DT cord-023095-4dannjjm 1404 10 VSPro vspro NN cord-023095-4dannjjm 1405 1 compared compare VBN cord-023095-4dannjjm 1405 2 to to IN cord-023095-4dannjjm 1405 3 the the DT cord-023095-4dannjjm 1405 4 ACL-1000 ACL-1000 NNP cord-023095-4dannjjm 1405 5 noted note VBD cord-023095-4dannjjm 1405 6 a a DT cord-023095-4dannjjm 1405 7 bias bias NN cord-023095-4dannjjm 1405 8 of of IN cord-023095-4dannjjm 1405 9 À84 À84 NNP cord-023095-4dannjjm 1405 10 AE AE NNP cord-023095-4dannjjm 1405 11 57 57 CD cord-023095-4dannjjm 1405 12 mg mg NNP cord-023095-4dannjjm 1405 13 / / SYM cord-023095-4dannjjm 1405 14 dL dl NN cord-023095-4dannjjm 1406 1 The the DT cord-023095-4dannjjm 1406 2 results result NNS cord-023095-4dannjjm 1406 3 of of IN cord-023095-4dannjjm 1406 4 this this DT cord-023095-4dannjjm 1406 5 study study NN cord-023095-4dannjjm 1406 6 indicate indicate VBP cord-023095-4dannjjm 1406 7 that that IN cord-023095-4dannjjm 1406 8 the the DT cord-023095-4dannjjm 1406 9 VSPro VSPro VBN cord-023095-4dannjjm 1406 10 benchtop benchtop NN cord-023095-4dannjjm 1406 11 fibrinogen fibrinogen NN cord-023095-4dannjjm 1406 12 analyzer analyzer NN cord-023095-4dannjjm 1406 13 provides provide VBZ cord-023095-4dannjjm 1406 14 accurate accurate JJ cord-023095-4dannjjm 1406 15 and and CC cord-023095-4dannjjm 1406 16 precise precise JJ cord-023095-4dannjjm 1406 17 fibrinogen fibrinogen NN cord-023095-4dannjjm 1406 18 data datum NNS cord-023095-4dannjjm 1406 19 compared compare VBN cord-023095-4dannjjm 1406 20 to to IN cord-023095-4dannjjm 1406 21 the the DT cord-023095-4dannjjm 1406 22 ACL-1000 ACL-1000 NNP cord-023095-4dannjjm 1406 23 reference reference NN cord-023095-4dannjjm 1406 24 analyzer analyzer NN cord-023095-4dannjjm 1406 25 . . . cord-023095-4dannjjm 1407 1 The the DT cord-023095-4dannjjm 1407 2 immune immune JJ cord-023095-4dannjjm 1407 3 response response NN cord-023095-4dannjjm 1407 4 of of IN cord-023095-4dannjjm 1407 5 foals foal NNS cord-023095-4dannjjm 1407 6 to to IN cord-023095-4dannjjm 1407 7 R. R. NNP cord-023095-4dannjjm 1407 8 equi equi NN cord-023095-4dannjjm 1407 9 is be VBZ cord-023095-4dannjjm 1407 10 incompletely incompletely RB cord-023095-4dannjjm 1407 11 understood understand VBN cord-023095-4dannjjm 1407 12 and and CC cord-023095-4dannjjm 1407 13 believed believe VBN cord-023095-4dannjjm 1407 14 to to TO cord-023095-4dannjjm 1407 15 be be VB cord-023095-4dannjjm 1407 16 responsible responsible JJ cord-023095-4dannjjm 1407 17 for for IN cord-023095-4dannjjm 1407 18 clinical clinical JJ cord-023095-4dannjjm 1407 19 disease disease NN cord-023095-4dannjjm 1407 20 caused cause VBN cord-023095-4dannjjm 1407 21 by by IN cord-023095-4dannjjm 1407 22 this this DT cord-023095-4dannjjm 1407 23 pulmonary pulmonary JJ cord-023095-4dannjjm 1407 24 pathogen pathogen NN cord-023095-4dannjjm 1407 25 . . . cord-023095-4dannjjm 1408 1 In in IN cord-023095-4dannjjm 1408 2 a a DT cord-023095-4dannjjm 1408 3 recent recent JJ cord-023095-4dannjjm 1408 4 study study NN cord-023095-4dannjjm 1408 5 foals foal NNS cord-023095-4dannjjm 1408 6 receiving receive VBG cord-023095-4dannjjm 1408 7 a a DT cord-023095-4dannjjm 1408 8 large large JJ cord-023095-4dannjjm 1408 9 inoculum inoculum NN cord-023095-4dannjjm 1408 10 exhibited exhibit VBD cord-023095-4dannjjm 1408 11 Th2 Th2 NNP cord-023095-4dannjjm 1408 12 skewing skew VBG cord-023095-4dannjjm 1408 13 with with IN cord-023095-4dannjjm 1408 14 pneumonia pneumonia NN cord-023095-4dannjjm 1408 15 and and CC cord-023095-4dannjjm 1408 16 a a DT cord-023095-4dannjjm 1408 17 small small JJ cord-023095-4dannjjm 1408 18 inoculum inoculum NN cord-023095-4dannjjm 1408 19 exhibited exhibit VBD cord-023095-4dannjjm 1408 20 Th1 th1 NN cord-023095-4dannjjm 1408 21 skewing skew VBG cord-023095-4dannjjm 1408 22 without without IN cord-023095-4dannjjm 1408 23 clinical clinical JJ cord-023095-4dannjjm 1408 24 disease disease NN cord-023095-4dannjjm 1408 25 . . . cord-023095-4dannjjm 1409 1 We -PRON- PRP cord-023095-4dannjjm 1409 2 hypothesized hypothesize VBD cord-023095-4dannjjm 1409 3 that that IN cord-023095-4dannjjm 1409 4 cytokine cytokine NN cord-023095-4dannjjm 1409 5 / / SYM cord-023095-4dannjjm 1409 6 chemokine chemokine NN cord-023095-4dannjjm 1409 7 production production NN cord-023095-4dannjjm 1409 8 by by IN cord-023095-4dannjjm 1409 9 pulmonary pulmonary JJ cord-023095-4dannjjm 1409 10 alveolar alveolar NN cord-023095-4dannjjm 1409 11 macrophages macrophage NNS cord-023095-4dannjjm 1409 12 , , , cord-023095-4dannjjm 1409 13 in in IN cord-023095-4dannjjm 1409 14 vitro vitro FW cord-023095-4dannjjm 1409 15 , , , cord-023095-4dannjjm 1409 16 would would MD cord-023095-4dannjjm 1409 17 increase increase VB cord-023095-4dannjjm 1409 18 with with IN cord-023095-4dannjjm 1409 19 the the DT cord-023095-4dannjjm 1409 20 infective infective JJ cord-023095-4dannjjm 1409 21 dose dose NN cord-023095-4dannjjm 1409 22 and and CC cord-023095-4dannjjm 1409 23 that that IN cord-023095-4dannjjm 1409 24 the the DT cord-023095-4dannjjm 1409 25 magnitude magnitude NN cord-023095-4dannjjm 1409 26 of of IN cord-023095-4dannjjm 1409 27 the the DT cord-023095-4dannjjm 1409 28 response response NN cord-023095-4dannjjm 1409 29 would would MD cord-023095-4dannjjm 1409 30 differ differ VB cord-023095-4dannjjm 1409 31 between between IN cord-023095-4dannjjm 1409 32 foals foal NNS cord-023095-4dannjjm 1409 33 and and CC cord-023095-4dannjjm 1409 34 adults adult NNS cord-023095-4dannjjm 1409 35 . . . cord-023095-4dannjjm 1410 1 Alveolar alveolar NN cord-023095-4dannjjm 1410 2 macrophages macrophage NNS cord-023095-4dannjjm 1410 3 were be VBD cord-023095-4dannjjm 1410 4 obtained obtain VBN cord-023095-4dannjjm 1410 5 by by IN cord-023095-4dannjjm 1410 6 bronchoalevolar bronchoalevolar NNP cord-023095-4dannjjm 1410 7 lavage lavage NN cord-023095-4dannjjm 1410 8 from from IN cord-023095-4dannjjm 1410 9 7 7 CD cord-023095-4dannjjm 1410 10 healthy healthy JJ cord-023095-4dannjjm 1410 11 mares mare NNS cord-023095-4dannjjm 1410 12 and and CC cord-023095-4dannjjm 1410 13 their -PRON- PRP$ cord-023095-4dannjjm 1410 14 5-week 5-week JJ cord-023095-4dannjjm 1410 15 - - HYPH cord-023095-4dannjjm 1410 16 old old JJ cord-023095-4dannjjm 1410 17 foals foal NNS cord-023095-4dannjjm 1410 18 . . . cord-023095-4dannjjm 1411 1 Macrophage macrophage NN cord-023095-4dannjjm 1411 2 cultures culture NNS cord-023095-4dannjjm 1411 3 were be VBD cord-023095-4dannjjm 1411 4 infected infect VBN cord-023095-4dannjjm 1411 5 with with IN cord-023095-4dannjjm 1411 6 R. R. NNP cord-023095-4dannjjm 1411 7 equi equi NN cord-023095-4dannjjm 1411 8 ( ( -LRB- cord-023095-4dannjjm 1411 9 337011 337011 CD cord-023095-4dannjjm 1411 10 or or CC cord-023095-4dannjjm 1411 11 33701- 33701- NNP cord-023095-4dannjjm 1411 12 ) ) -RRB- cord-023095-4dannjjm 1411 13 at at IN cord-023095-4dannjjm 1411 14 a a DT cord-023095-4dannjjm 1411 15 multiplicity multiplicity NN cord-023095-4dannjjm 1411 16 of of IN cord-023095-4dannjjm 1411 17 infection infection NN cord-023095-4dannjjm 1411 18 ( ( -LRB- cord-023095-4dannjjm 1411 19 MOI MOI NNP cord-023095-4dannjjm 1411 20 ) ) -RRB- cord-023095-4dannjjm 1411 21 of of IN cord-023095-4dannjjm 1411 22 1 1 CD cord-023095-4dannjjm 1411 23 or or CC cord-023095-4dannjjm 1411 24 100 100 CD cord-023095-4dannjjm 1411 25 . . . cord-023095-4dannjjm 1412 1 Total Total NNP cord-023095-4dannjjm 1412 2 RNA RNA NNP cord-023095-4dannjjm 1412 3 was be VBD cord-023095-4dannjjm 1412 4 harvested harvest VBN cord-023095-4dannjjm 1412 5 4 4 CD cord-023095-4dannjjm 1412 6 and and CC cord-023095-4dannjjm 1412 7 24 24 CD cord-023095-4dannjjm 1412 8 hours hour NNS cord-023095-4dannjjm 1412 9 post post NN cord-023095-4dannjjm 1412 10 - - NN cord-023095-4dannjjm 1412 11 infection infection JJ cord-023095-4dannjjm 1412 12 , , , cord-023095-4dannjjm 1412 13 reverse reverse VB cord-023095-4dannjjm 1412 14 transcribed transcribe VBN cord-023095-4dannjjm 1412 15 and and CC cord-023095-4dannjjm 1412 16 used use VBN cord-023095-4dannjjm 1412 17 as as IN cord-023095-4dannjjm 1412 18 template template NN cord-023095-4dannjjm 1412 19 for for IN cord-023095-4dannjjm 1412 20 quantita quantita NNP cord-023095-4dannjjm 1412 21 - - HYPH cord-023095-4dannjjm 1412 22 tive tive JJ cord-023095-4dannjjm 1412 23 PCR PCR NNP cord-023095-4dannjjm 1412 24 . . . cord-023095-4dannjjm 1413 1 The the DT cord-023095-4dannjjm 1413 2 DDCt DDCt NNS cord-023095-4dannjjm 1413 3 method method NN cord-023095-4dannjjm 1413 4 was be VBD cord-023095-4dannjjm 1413 5 used use VBN cord-023095-4dannjjm 1413 6 to to TO cord-023095-4dannjjm 1413 7 calculate calculate VB cord-023095-4dannjjm 1413 8 relative relative JJ cord-023095-4dannjjm 1413 9 gene gene NN cord-023095-4dannjjm 1413 10 transcripts transcript NNS cord-023095-4dannjjm 1413 11 for for IN cord-023095-4dannjjm 1413 12 IL-6 IL-6 NNP cord-023095-4dannjjm 1413 13 , , , cord-023095-4dannjjm 1413 14 IL-12p40 IL-12p40 NNP cord-023095-4dannjjm 1413 15 , , , cord-023095-4dannjjm 1413 16 TNFa TNFa NNP cord-023095-4dannjjm 1413 17 and and CC cord-023095-4dannjjm 1413 18 CXCL10 CXCL10 NNP cord-023095-4dannjjm 1413 19 . . . cord-023095-4dannjjm 1414 1 Cellular cellular JJ cord-023095-4dannjjm 1414 2 infections infection NNS cord-023095-4dannjjm 1414 3 at at IN cord-023095-4dannjjm 1414 4 MOI MOI NNP cord-023095-4dannjjm 1414 5 100 100 CD cord-023095-4dannjjm 1414 6 resulted result VBD cord-023095-4dannjjm 1414 7 in in IN cord-023095-4dannjjm 1414 8 significantly significantly RB cord-023095-4dannjjm 1414 9 higher high JJR cord-023095-4dannjjm 1414 10 expression expression NN cord-023095-4dannjjm 1414 11 of of IN cord-023095-4dannjjm 1414 12 IL-6 IL-6 NNP cord-023095-4dannjjm 1414 13 , , , cord-023095-4dannjjm 1414 14 IL-12p40 IL-12p40 NNP cord-023095-4dannjjm 1414 15 and and CC cord-023095-4dannjjm 1414 16 TNFa TNFa NNP cord-023095-4dannjjm 1414 17 mRNA mrna NN cord-023095-4dannjjm 1414 18 transcripts transcript NNS cord-023095-4dannjjm 1414 19 compared compare VBN cord-023095-4dannjjm 1414 20 to to IN cord-023095-4dannjjm 1414 21 MOI MOI NNP cord-023095-4dannjjm 1414 22 1 1 CD cord-023095-4dannjjm 1414 23 . . . cord-023095-4dannjjm 1415 1 However however RB cord-023095-4dannjjm 1415 2 , , , cord-023095-4dannjjm 1415 3 the the DT cord-023095-4dannjjm 1415 4 dose dose NN cord-023095-4dannjjm 1415 5 - - HYPH cord-023095-4dannjjm 1415 6 effect effect NN cord-023095-4dannjjm 1415 7 was be VBD cord-023095-4dannjjm 1415 8 reversed reverse VBN cord-023095-4dannjjm 1415 9 for for IN cord-023095-4dannjjm 1415 10 CXCL10 CXCL10 NNP cord-023095-4dannjjm 1415 11 with with IN cord-023095-4dannjjm 1415 12 significantly significantly RB cord-023095-4dannjjm 1415 13 lower low JJR cord-023095-4dannjjm 1415 14 expression expression NN cord-023095-4dannjjm 1415 15 at at IN cord-023095-4dannjjm 1415 16 the the DT cord-023095-4dannjjm 1415 17 higher high JJR cord-023095-4dannjjm 1415 18 MOI MOI NNP cord-023095-4dannjjm 1415 19 . . . cord-023095-4dannjjm 1416 1 There there EX cord-023095-4dannjjm 1416 2 was be VBD cord-023095-4dannjjm 1416 3 no no DT cord-023095-4dannjjm 1416 4 difference difference NN cord-023095-4dannjjm 1416 5 in in IN cord-023095-4dannjjm 1416 6 magnitude magnitude NN cord-023095-4dannjjm 1416 7 of of IN cord-023095-4dannjjm 1416 8 cytokine cytokine NN cord-023095-4dannjjm 1416 9 / / SYM cord-023095-4dannjjm 1416 10 chemokine chemokine NN cord-023095-4dannjjm 1416 11 responses response NNS cord-023095-4dannjjm 1416 12 by by IN cord-023095-4dannjjm 1416 13 the the DT cord-023095-4dannjjm 1416 14 alveolar alveolar JJ cord-023095-4dannjjm 1416 15 macrophages macrophage NNS cord-023095-4dannjjm 1416 16 between between IN cord-023095-4dannjjm 1416 17 adults adult NNS cord-023095-4dannjjm 1416 18 and and CC cord-023095-4dannjjm 1416 19 foals foal NNS cord-023095-4dannjjm 1416 20 . . . cord-023095-4dannjjm 1417 1 Dose dose JJ cord-023095-4dannjjm 1417 2 - - HYPH cord-023095-4dannjjm 1417 3 dependent dependent JJ cord-023095-4dannjjm 1417 4 responses response NNS cord-023095-4dannjjm 1417 5 of of IN cord-023095-4dannjjm 1417 6 alveolar alveolar JJ cord-023095-4dannjjm 1417 7 macrophages macrophage NNS cord-023095-4dannjjm 1417 8 may may MD cord-023095-4dannjjm 1417 9 represent represent VB cord-023095-4dannjjm 1417 10 a a DT cord-023095-4dannjjm 1417 11 novel novel JJ cord-023095-4dannjjm 1417 12 mechanism mechanism NN cord-023095-4dannjjm 1417 13 by by IN cord-023095-4dannjjm 1417 14 which which WDT cord-023095-4dannjjm 1417 15 R. R. NNP cord-023095-4dannjjm 1417 16 equi equi NN cord-023095-4dannjjm 1417 17 could could MD cord-023095-4dannjjm 1417 18 modulate modulate VB cord-023095-4dannjjm 1417 19 immune immune JJ cord-023095-4dannjjm 1417 20 responses response NNS cord-023095-4dannjjm 1417 21 and and CC cord-023095-4dannjjm 1417 22 therefore therefore RB cord-023095-4dannjjm 1417 23 disease disease NN cord-023095-4dannjjm 1417 24 . . . cord-023095-4dannjjm 1418 1 Significant significant JJ cord-023095-4dannjjm 1418 2 down down JJ cord-023095-4dannjjm 1418 3 - - HYPH cord-023095-4dannjjm 1418 4 regulation regulation NN cord-023095-4dannjjm 1418 5 of of IN cord-023095-4dannjjm 1418 6 CXCL10 CXCL10 NNP cord-023095-4dannjjm 1418 7 mRNA mrna NN cord-023095-4dannjjm 1418 8 transcripts transcript NNS cord-023095-4dannjjm 1418 9 associated associate VBN cord-023095-4dannjjm 1418 10 with with IN cord-023095-4dannjjm 1418 11 a a DT cord-023095-4dannjjm 1418 12 higher high JJR cord-023095-4dannjjm 1418 13 dose dose NN cord-023095-4dannjjm 1418 14 is be VBZ cord-023095-4dannjjm 1418 15 of of IN cord-023095-4dannjjm 1418 16 particular particular JJ cord-023095-4dannjjm 1418 17 interest interest NN cord-023095-4dannjjm 1418 18 as as IN cord-023095-4dannjjm 1418 19 this this DT cord-023095-4dannjjm 1418 20 chemokine chemokine NN cord-023095-4dannjjm 1418 21 plays play VBZ cord-023095-4dannjjm 1418 22 a a DT cord-023095-4dannjjm 1418 23 role role NN cord-023095-4dannjjm 1418 24 in in IN cord-023095-4dannjjm 1418 25 development development NN cord-023095-4dannjjm 1418 26 of of IN cord-023095-4dannjjm 1418 27 protective protective JJ cord-023095-4dannjjm 1418 28 Th1 th1 CD cord-023095-4dannjjm 1418 29 responses response NNS cord-023095-4dannjjm 1418 30 . . . cord-023095-4dannjjm 1419 1 The the DT cord-023095-4dannjjm 1419 2 intent intent NN cord-023095-4dannjjm 1419 3 of of IN cord-023095-4dannjjm 1419 4 this this DT cord-023095-4dannjjm 1419 5 study study NN cord-023095-4dannjjm 1419 6 was be VBD cord-023095-4dannjjm 1419 7 to to TO cord-023095-4dannjjm 1419 8 develop develop VB cord-023095-4dannjjm 1419 9 likelihood likelihood NN cord-023095-4dannjjm 1419 10 ratios ratio NNS cord-023095-4dannjjm 1419 11 ( ( -LRB- cord-023095-4dannjjm 1419 12 LRs LRs NNP cord-023095-4dannjjm 1419 13 ) ) -RRB- cord-023095-4dannjjm 1419 14 for for IN cord-023095-4dannjjm 1419 15 infection infection NN cord-023095-4dannjjm 1419 16 attributable attributable JJ cord-023095-4dannjjm 1419 17 to to IN cord-023095-4dannjjm 1419 18 Corynebacterium Corynebacterium NNP cord-023095-4dannjjm 1419 19 pseudotuberculosis pseudotuberculosis NN cord-023095-4dannjjm 1419 20 in in IN cord-023095-4dannjjm 1419 21 horses horse NNS cord-023095-4dannjjm 1419 22 based base VBN cord-023095-4dannjjm 1419 23 on on IN cord-023095-4dannjjm 1419 24 synergistic synergistic JJ cord-023095-4dannjjm 1419 25 hemolysis hemolysis NN cord-023095-4dannjjm 1419 26 inhibition inhibition NN cord-023095-4dannjjm 1419 27 ( ( -LRB- cord-023095-4dannjjm 1419 28 SHI SHI NNP cord-023095-4dannjjm 1419 29 ) ) -RRB- cord-023095-4dannjjm 1419 30 test test NN cord-023095-4dannjjm 1419 31 titers titer NNS cord-023095-4dannjjm 1419 32 . . . cord-023095-4dannjjm 1420 1 Medical medical JJ cord-023095-4dannjjm 1420 2 records record NNS cord-023095-4dannjjm 1420 3 for for IN cord-023095-4dannjjm 1420 4 horses horse NNS cord-023095-4dannjjm 1420 5 presented present VBN cord-023095-4dannjjm 1420 6 to to IN cord-023095-4dannjjm 1420 7 the the DT cord-023095-4dannjjm 1420 8 UC UC NNP cord-023095-4dannjjm 1420 9 Davis Davis NNP cord-023095-4dannjjm 1420 10 Veterinary Veterinary NNP cord-023095-4dannjjm 1420 11 Teaching Teaching NNP cord-023095-4dannjjm 1420 12 Hospital Hospital NNP cord-023095-4dannjjm 1420 13 with with IN cord-023095-4dannjjm 1420 14 serum serum NN cord-023095-4dannjjm 1420 15 submitted submit VBN cord-023095-4dannjjm 1420 16 for for IN cord-023095-4dannjjm 1420 17 SHI SHI NNP cord-023095-4dannjjm 1420 18 titer titer NN cord-023095-4dannjjm 1420 19 determination determination NN cord-023095-4dannjjm 1420 20 were be VBD cord-023095-4dannjjm 1420 21 evaluated evaluate VBN cord-023095-4dannjjm 1420 22 and and CC cord-023095-4dannjjm 1420 23 171 171 CD cord-023095-4dannjjm 1420 24 cases case NNS cord-023095-4dannjjm 1420 25 met meet VBD cord-023095-4dannjjm 1420 26 study study NN cord-023095-4dannjjm 1420 27 inclusion inclusion NN cord-023095-4dannjjm 1420 28 criteria criterion NNS cord-023095-4dannjjm 1420 29 . . . cord-023095-4dannjjm 1421 1 These these DT cord-023095-4dannjjm 1421 2 cases case NNS cord-023095-4dannjjm 1421 3 were be VBD cord-023095-4dannjjm 1421 4 grouped group VBN cord-023095-4dannjjm 1421 5 based base VBN cord-023095-4dannjjm 1421 6 on on IN cord-023095-4dannjjm 1421 7 evidence evidence NN cord-023095-4dannjjm 1421 8 of of IN cord-023095-4dannjjm 1421 9 internal internal JJ cord-023095-4dannjjm 1421 10 and/or and/or CC cord-023095-4dannjjm 1421 11 external external JJ cord-023095-4dannjjm 1421 12 infection infection NN cord-023095-4dannjjm 1421 13 attributable attributable JJ cord-023095-4dannjjm 1421 14 to to IN cord-023095-4dannjjm 1421 15 C. C. NNP cord-023095-4dannjjm 1421 16 pseudotuberculosis pseudotuberculosis NN cord-023095-4dannjjm 1421 17 and and CC cord-023095-4dannjjm 1421 18 likelihood likelihood NN cord-023095-4dannjjm 1421 19 ratios ratio NNS cord-023095-4dannjjm 1421 20 with with IN cord-023095-4dannjjm 1421 21 95 95 CD cord-023095-4dannjjm 1421 22 % % NN cord-023095-4dannjjm 1421 23 confidence confidence NN cord-023095-4dannjjm 1421 24 intervals interval NNS cord-023095-4dannjjm 1421 25 determined determine VBN cord-023095-4dannjjm 1421 26 . . . cord-023095-4dannjjm 1422 1 Results result NNS cord-023095-4dannjjm 1422 2 showed show VBD cord-023095-4dannjjm 1422 3 increasing increase VBG cord-023095-4dannjjm 1422 4 LRs lr NNS cord-023095-4dannjjm 1422 5 indicating indicate VBG cord-023095-4dannjjm 1422 6 increasing increase VBG cord-023095-4dannjjm 1422 7 odds odd NNS cord-023095-4dannjjm 1422 8 for for IN cord-023095-4dannjjm 1422 9 any any DT cord-023095-4dannjjm 1422 10 form form NN cord-023095-4dannjjm 1422 11 of of IN cord-023095-4dannjjm 1422 12 active active JJ cord-023095-4dannjjm 1422 13 disease disease NN cord-023095-4dannjjm 1422 14 as as IN cord-023095-4dannjjm 1422 15 titer titer NN cord-023095-4dannjjm 1422 16 increased increase VBD cord-023095-4dannjjm 1422 17 with with IN cord-023095-4dannjjm 1422 18 all all DT cord-023095-4dannjjm 1422 19 cases case NNS cord-023095-4dannjjm 1422 20 considered consider VBN cord-023095-4dannjjm 1422 21 . . . cord-023095-4dannjjm 1423 1 LRs LRs NNP cord-023095-4dannjjm 1423 2 for for IN cord-023095-4dannjjm 1423 3 internal internal JJ cord-023095-4dannjjm 1423 4 infection infection NN cord-023095-4dannjjm 1423 5 were be VBD cord-023095-4dannjjm 1423 6 4 4 CD cord-023095-4dannjjm 1423 7 1 1 CD cord-023095-4dannjjm 1423 8 for for IN cord-023095-4dannjjm 1423 9 titers titer NNS cord-023095-4dannjjm 1423 10 ! ! . cord-023095-4dannjjm 1424 1 1280 1280 CD cord-023095-4dannjjm 1424 2 overall overall RB cord-023095-4dannjjm 1424 3 and and CC cord-023095-4dannjjm 1424 4 for for IN cord-023095-4dannjjm 1424 5 titers titer NNS cord-023095-4dannjjm 1424 6 4 4 CD cord-023095-4dannjjm 1424 7 160 160 CD cord-023095-4dannjjm 1424 8 with with IN cord-023095-4dannjjm 1424 9 external external JJ cord-023095-4dannjjm 1424 10 abscess abscess NN cord-023095-4dannjjm 1424 11 cases case NNS cord-023095-4dannjjm 1424 12 excluded exclude VBN cord-023095-4dannjjm 1424 13 . . . cord-023095-4dannjjm 1425 1 No no DT cord-023095-4dannjjm 1425 2 difference difference NN cord-023095-4dannjjm 1425 3 from from IN cord-023095-4dannjjm 1425 4 1 1 CD cord-023095-4dannjjm 1425 5 ( ( -LRB- cord-023095-4dannjjm 1425 6 and and CC cord-023095-4dannjjm 1425 7 therefore therefore RB cord-023095-4dannjjm 1425 8 no no DT cord-023095-4dannjjm 1425 9 significant significant JJ cord-023095-4dannjjm 1425 10 change change NN cord-023095-4dannjjm 1425 11 in in IN cord-023095-4dannjjm 1425 12 pre pre JJ cord-023095-4dannjjm 1425 13 - - JJ cord-023095-4dannjjm 1425 14 test test NN cord-023095-4dannjjm 1425 15 to to TO cord-023095-4dannjjm 1425 16 post post VB cord-023095-4dannjjm 1425 17 - - JJ cord-023095-4dannjjm 1425 18 test test JJ cord-023095-4dannjjm 1425 19 odds odd NNS cord-023095-4dannjjm 1425 20 ) ) -RRB- cord-023095-4dannjjm 1425 21 was be VBD cord-023095-4dannjjm 1425 22 seen see VBN cord-023095-4dannjjm 1425 23 in in IN cord-023095-4dannjjm 1425 24 any any DT cord-023095-4dannjjm 1425 25 LRs LRs NNP cord-023095-4dannjjm 1425 26 for for IN cord-023095-4dannjjm 1425 27 internal internal JJ cord-023095-4dannjjm 1425 28 disease disease NN cord-023095-4dannjjm 1425 29 when when WRB cord-023095-4dannjjm 1425 30 only only RB cord-023095-4dannjjm 1425 31 cases case NNS cord-023095-4dannjjm 1425 32 with with IN cord-023095-4dannjjm 1425 33 external external JJ cord-023095-4dannjjm 1425 34 disease disease NN cord-023095-4dannjjm 1425 35 were be VBD cord-023095-4dannjjm 1425 36 examined examine VBN cord-023095-4dannjjm 1425 37 ( ( -LRB- cord-023095-4dannjjm 1425 38 external external JJ cord-023095-4dannjjm 1425 39 and and CC cord-023095-4dannjjm 1425 40 internal internal JJ cord-023095-4dannjjm 1425 41 disease disease NN cord-023095-4dannjjm 1425 42 vs. vs. FW cord-023095-4dannjjm 1425 43 external external JJ cord-023095-4dannjjm 1425 44 only only RB cord-023095-4dannjjm 1425 45 ) ) -RRB- cord-023095-4dannjjm 1425 46 . . . cord-023095-4dannjjm 1426 1 Overall overall RB cord-023095-4dannjjm 1426 2 , , , cord-023095-4dannjjm 1426 3 the the DT cord-023095-4dannjjm 1426 4 SHI SHI NNP cord-023095-4dannjjm 1426 5 test test NN cord-023095-4dannjjm 1426 6 results result NNS cord-023095-4dannjjm 1426 7 showed show VBD cord-023095-4dannjjm 1426 8 usefulness usefulness NN cord-023095-4dannjjm 1426 9 in in IN cord-023095-4dannjjm 1426 10 determining determine VBG cord-023095-4dannjjm 1426 11 internal internal JJ cord-023095-4dannjjm 1426 12 C. C. NNP cord-023095-4dannjjm 1426 13 pseudotuberculosis pseudotuberculosis NN cord-023095-4dannjjm 1426 14 infection infection NN cord-023095-4dannjjm 1426 15 in in IN cord-023095-4dannjjm 1426 16 horses horse NNS cord-023095-4dannjjm 1426 17 with with IN cord-023095-4dannjjm 1426 18 no no DT cord-023095-4dannjjm 1426 19 evidence evidence NN cord-023095-4dannjjm 1426 20 of of IN cord-023095-4dannjjm 1426 21 external external JJ cord-023095-4dannjjm 1426 22 abscessation abscessation NN cord-023095-4dannjjm 1426 23 . . . cord-023095-4dannjjm 1427 1 Overall overall RB cord-023095-4dannjjm 1427 2 , , , cord-023095-4dannjjm 1427 3 however however RB cord-023095-4dannjjm 1427 4 , , , cord-023095-4dannjjm 1427 5 higher high JJR cord-023095-4dannjjm 1427 6 titers titer NNS cord-023095-4dannjjm 1427 7 were be VBD cord-023095-4dannjjm 1427 8 more more RBR cord-023095-4dannjjm 1427 9 indicative indicative JJ cord-023095-4dannjjm 1427 10 of of IN cord-023095-4dannjjm 1427 11 active active JJ cord-023095-4dannjjm 1427 12 external external JJ cord-023095-4dannjjm 1427 13 or or CC cord-023095-4dannjjm 1427 14 internal internal JJ cord-023095-4dannjjm 1427 15 disease disease NN cord-023095-4dannjjm 1427 16 than than IN cord-023095-4dannjjm 1427 17 internal internal JJ cord-023095-4dannjjm 1427 18 disease disease NN cord-023095-4dannjjm 1427 19 specifically specifically RB cord-023095-4dannjjm 1427 20 in in IN cord-023095-4dannjjm 1427 21 contrast contrast NN cord-023095-4dannjjm 1427 22 to to IN cord-023095-4dannjjm 1427 23 previous previous JJ cord-023095-4dannjjm 1427 24 reports report NNS cord-023095-4dannjjm 1427 25 . . . cord-023095-4dannjjm 1428 1 The the DT cord-023095-4dannjjm 1428 2 SHI SHI NNP cord-023095-4dannjjm 1428 3 test test NN cord-023095-4dannjjm 1428 4 was be VBD cord-023095-4dannjjm 1428 5 unable unable JJ cord-023095-4dannjjm 1428 6 to to TO cord-023095-4dannjjm 1428 7 distinguish distinguish VB cord-023095-4dannjjm 1428 8 internal internal JJ cord-023095-4dannjjm 1428 9 infection infection NN cord-023095-4dannjjm 1428 10 when when WRB cord-023095-4dannjjm 1428 11 external external JJ cord-023095-4dannjjm 1428 12 abscesses abscess NNS cord-023095-4dannjjm 1428 13 were be VBD cord-023095-4dannjjm 1428 14 present present JJ cord-023095-4dannjjm 1428 15 . . . cord-023095-4dannjjm 1429 1 Salmonella Salmonella NNP cord-023095-4dannjjm 1429 2 enterica enterica NN cord-023095-4dannjjm 1429 3 is be VBZ cord-023095-4dannjjm 1429 4 a a DT cord-023095-4dannjjm 1429 5 zoonotic zoonotic JJ cord-023095-4dannjjm 1429 6 pathogen pathogen NN cord-023095-4dannjjm 1429 7 that that WDT cord-023095-4dannjjm 1429 8 has have VBZ cord-023095-4dannjjm 1429 9 tremendous tremendous JJ cord-023095-4dannjjm 1429 10 impact impact NN cord-023095-4dannjjm 1429 11 on on IN cord-023095-4dannjjm 1429 12 many many JJ cord-023095-4dannjjm 1429 13 different different JJ cord-023095-4dannjjm 1429 14 animal animal NN cord-023095-4dannjjm 1429 15 production production NN cord-023095-4dannjjm 1429 16 and and CC cord-023095-4dannjjm 1429 17 management management NN cord-023095-4dannjjm 1429 18 systems system NNS cord-023095-4dannjjm 1429 19 . . . cord-023095-4dannjjm 1430 1 Rapid rapid JJ cord-023095-4dannjjm 1430 2 detection detection NN cord-023095-4dannjjm 1430 3 of of IN cord-023095-4dannjjm 1430 4 S. S. NNP cord-023095-4dannjjm 1430 5 enterica enterica NN cord-023095-4dannjjm 1430 6 in in IN cord-023095-4dannjjm 1430 7 fecal fecal JJ cord-023095-4dannjjm 1430 8 samples sample NNS cord-023095-4dannjjm 1430 9 may may MD cord-023095-4dannjjm 1430 10 facilitate facilitate VB cord-023095-4dannjjm 1430 11 effective effective JJ cord-023095-4dannjjm 1430 12 infection infection NN cord-023095-4dannjjm 1430 13 control control NN cord-023095-4dannjjm 1430 14 practices practice NNS cord-023095-4dannjjm 1430 15 . . . cord-023095-4dannjjm 1431 1 Current current JJ cord-023095-4dannjjm 1431 2 detection detection NN cord-023095-4dannjjm 1431 3 methods method NNS cord-023095-4dannjjm 1431 4 require require VBP cord-023095-4dannjjm 1431 5 24 24 CD cord-023095-4dannjjm 1431 6 - - SYM cord-023095-4dannjjm 1431 7 48 48 CD cord-023095-4dannjjm 1431 8 hours hour NNS cord-023095-4dannjjm 1432 1 ( ( -LRB- cord-023095-4dannjjm 1432 2 Polymerase Polymerase NNP cord-023095-4dannjjm 1432 3 Chain Chain NNP cord-023095-4dannjjm 1432 4 Reaction Reaction NNP cord-023095-4dannjjm 1432 5 or or CC cord-023095-4dannjjm 1432 6 PCR PCR NNP cord-023095-4dannjjm 1432 7 ) ) -RRB- cord-023095-4dannjjm 1432 8 or or CC cord-023095-4dannjjm 1432 9 48 48 CD cord-023095-4dannjjm 1432 10 - - SYM cord-023095-4dannjjm 1432 11 72 72 CD cord-023095-4dannjjm 1432 12 hours hour NNS cord-023095-4dannjjm 1432 13 ( ( -LRB- cord-023095-4dannjjm 1432 14 enriched enrich VBN cord-023095-4dannjjm 1432 15 aerobic aerobic JJ cord-023095-4dannjjm 1432 16 culture culture NN cord-023095-4dannjjm 1432 17 ) ) -RRB- cord-023095-4dannjjm 1433 1 to to TO cord-023095-4dannjjm 1433 2 obtain obtain VB cord-023095-4dannjjm 1433 3 results result NNS cord-023095-4dannjjm 1433 4 . . . cord-023095-4dannjjm 1434 1 Alternatives alternative NNS cord-023095-4dannjjm 1434 2 have have VBP cord-023095-4dannjjm 1434 3 been be VBN cord-023095-4dannjjm 1434 4 developed develop VBN cord-023095-4dannjjm 1434 5 , , , cord-023095-4dannjjm 1434 6 lateral lateral JJ cord-023095-4dannjjm 1434 7 flow flow NN cord-023095-4dannjjm 1434 8 antigen antigen NN cord-023095-4dannjjm 1434 9 detection detection NN cord-023095-4dannjjm 1434 10 systems system NNS cord-023095-4dannjjm 1434 11 ( ( -LRB- cord-023095-4dannjjm 1434 12 LFADS LFADS NNP cord-023095-4dannjjm 1434 13 ) ) -RRB- cord-023095-4dannjjm 1434 14 , , , cord-023095-4dannjjm 1434 15 which which WDT cord-023095-4dannjjm 1434 16 are be VBP cord-023095-4dannjjm 1434 17 currently currently RB cord-023095-4dannjjm 1434 18 marketed market VBN cord-023095-4dannjjm 1434 19 for for IN cord-023095-4dannjjm 1434 20 Salmonella Salmonella NNP cord-023095-4dannjjm 1434 21 detection detection NN cord-023095-4dannjjm 1434 22 related relate VBN cord-023095-4dannjjm 1434 23 to to IN cord-023095-4dannjjm 1434 24 food food NN cord-023095-4dannjjm 1434 25 safety safety NN cord-023095-4dannjjm 1434 26 microbiology microbiology NN cord-023095-4dannjjm 1434 27 . . . cord-023095-4dannjjm 1435 1 The the DT cord-023095-4dannjjm 1435 2 objective objective NN cord-023095-4dannjjm 1435 3 of of IN cord-023095-4dannjjm 1435 4 this this DT cord-023095-4dannjjm 1435 5 study study NN cord-023095-4dannjjm 1435 6 was be VBD cord-023095-4dannjjm 1435 7 to to TO cord-023095-4dannjjm 1435 8 evaluate evaluate VB cord-023095-4dannjjm 1435 9 two two CD cord-023095-4dannjjm 1435 10 commercially commercially RB cord-023095-4dannjjm 1435 11 available available JJ cord-023095-4dannjjm 1435 12 rapid rapid JJ cord-023095-4dannjjm 1435 13 Salmonella Salmonella NNP cord-023095-4dannjjm 1435 14 detection detection NN cord-023095-4dannjjm 1435 15 systems system NNS cord-023095-4dannjjm 1435 16 in in IN cord-023095-4dannjjm 1435 17 equine equine JJ cord-023095-4dannjjm 1435 18 feces fece NNS cord-023095-4dannjjm 1435 19 . . . cord-023095-4dannjjm 1436 1 Fecal fecal JJ cord-023095-4dannjjm 1436 2 samples sample NNS cord-023095-4dannjjm 1436 3 collected collect VBN cord-023095-4dannjjm 1436 4 from from IN cord-023095-4dannjjm 1436 5 repeatedly repeatedly RB cord-023095-4dannjjm 1436 6 culture culture NN cord-023095-4dannjjm 1436 7 - - HYPH cord-023095-4dannjjm 1436 8 negative negative JJ cord-023095-4dannjjm 1436 9 horses horse NNS cord-023095-4dannjjm 1436 10 were be VBD cord-023095-4dannjjm 1436 11 inoculated inoculate VBN cord-023095-4dannjjm 1436 12 with with IN cord-023095-4dannjjm 1436 13 known know VBN cord-023095-4dannjjm 1436 14 concentrations concentration NNS cord-023095-4dannjjm 1436 15 of of IN cord-023095-4dannjjm 1436 16 Salmonella Salmonella NNP cord-023095-4dannjjm 1436 17 enterica enterica NN cord-023095-4dannjjm 1436 18 serotype serotype NN cord-023095-4dannjjm 1436 19 Typhimurium Typhimurium NNP cord-023095-4dannjjm 1436 20 ( ( -LRB- cord-023095-4dannjjm 1436 21 five five CD cord-023095-4dannjjm 1436 22 uninoculated uninoculated JJ cord-023095-4dannjjm 1436 23 control control NN cord-023095-4dannjjm 1436 24 samples sample NNS cord-023095-4dannjjm 1436 25 , , , cord-023095-4dannjjm 1436 26 and and CC cord-023095-4dannjjm 1436 27 5 5 CD cord-023095-4dannjjm 1436 28 samples sample NNS cord-023095-4dannjjm 1436 29 of of IN cord-023095-4dannjjm 1436 30 each each DT cord-023095-4dannjjm 1436 31 10-fold 10-fold CD cord-023095-4dannjjm 1436 32 dilution dilution NN cord-023095-4dannjjm 1436 33 [ [ -LRB- cord-023095-4dannjjm 1436 34 1.9 1.9 CD cord-023095-4dannjjm 1436 35 Â â CD cord-023095-4dannjjm 1436 36 10 10 CD cord-023095-4dannjjm 1436 37 0 0 CD cord-023095-4dannjjm 1436 38 -1.9 -1.9 CD cord-023095-4dannjjm 1436 39 Â â CD cord-023095-4dannjjm 1436 40 10 10 CD cord-023095-4dannjjm 1436 41 4 4 CD cord-023095-4dannjjm 1436 42 cfu cfu NN cord-023095-4dannjjm 1436 43 / / SYM cord-023095-4dannjjm 1436 44 gram gram NN cord-023095-4dannjjm 1436 45 of of IN cord-023095-4dannjjm 1436 46 feces fece NNS cord-023095-4dannjjm 1436 47 ] ] -RRB- cord-023095-4dannjjm 1436 48 ) ) -RRB- cord-023095-4dannjjm 1436 49 . . . cord-023095-4dannjjm 1437 1 All all DT cord-023095-4dannjjm 1437 2 samples sample NNS cord-023095-4dannjjm 1437 3 were be VBD cord-023095-4dannjjm 1437 4 aerobically aerobically RB cord-023095-4dannjjm 1437 5 cultured cultured JJ cord-023095-4dannjjm 1437 6 using use VBG cord-023095-4dannjjm 1437 7 a a DT cord-023095-4dannjjm 1437 8 standard standard JJ cord-023095-4dannjjm 1437 9 enrichment enrichment NN cord-023095-4dannjjm 1437 10 technique technique NN cord-023095-4dannjjm 1437 11 . . . cord-023095-4dannjjm 1438 1 In in IN cord-023095-4dannjjm 1438 2 a a DT cord-023095-4dannjjm 1438 3 blinded blinded JJ cord-023095-4dannjjm 1438 4 fashion fashion NN cord-023095-4dannjjm 1438 5 , , , cord-023095-4dannjjm 1438 6 samples sample NNS cord-023095-4dannjjm 1438 7 were be VBD cord-023095-4dannjjm 1438 8 tested test VBN cord-023095-4dannjjm 1438 9 using use VBG cord-023095-4dannjjm 1438 10 two two CD cord-023095-4dannjjm 1438 11 different different JJ cord-023095-4dannjjm 1438 12 LFADS LFADS NNP cord-023095-4dannjjm 1438 13 as as RB cord-023095-4dannjjm 1438 14 well well RB cord-023095-4dannjjm 1438 15 as as IN cord-023095-4dannjjm 1438 16 plated plate VBN cord-023095-4dannjjm 1438 17 on on IN cord-023095-4dannjjm 1438 18 agar agar JJ cord-023095-4dannjjm 1438 19 media medium NNS cord-023095-4dannjjm 1438 20 for for IN cord-023095-4dannjjm 1438 21 confirmatory confirmatory JJ cord-023095-4dannjjm 1438 22 testing testing NN cord-023095-4dannjjm 1438 23 . . . cord-023095-4dannjjm 1439 1 At at IN cord-023095-4dannjjm 1439 2 24 24 CD cord-023095-4dannjjm 1439 3 hours hour NNS cord-023095-4dannjjm 1439 4 of of IN cord-023095-4dannjjm 1439 5 incubation incubation NN cord-023095-4dannjjm 1439 6 , , , cord-023095-4dannjjm 1439 7 using use VBG cord-023095-4dannjjm 1439 8 bacterial bacterial JJ cord-023095-4dannjjm 1439 9 culture culture NN cord-023095-4dannjjm 1439 10 as as IN cord-023095-4dannjjm 1439 11 the the DT cord-023095-4dannjjm 1439 12 reference reference NN cord-023095-4dannjjm 1439 13 method method NN cord-023095-4dannjjm 1439 14 , , , cord-023095-4dannjjm 1439 15 Test test NN cord-023095-4dannjjm 1439 16 1 1 CD cord-023095-4dannjjm 1439 17 was be VBD cord-023095-4dannjjm 1439 18 correctly correctly RB cord-023095-4dannjjm 1439 19 identify identify VB cord-023095-4dannjjm 1439 20 70 70 CD cord-023095-4dannjjm 1439 21 % % NN cord-023095-4dannjjm 1439 22 of of IN cord-023095-4dannjjm 1439 23 samples sample NNS cord-023095-4dannjjm 1439 24 ( ( -LRB- cord-023095-4dannjjm 1439 25 Bacterial bacterial JJ cord-023095-4dannjjm 1439 26 contamination contamination NN cord-023095-4dannjjm 1439 27 of of IN cord-023095-4dannjjm 1439 28 stalls stall NNS cord-023095-4dannjjm 1439 29 with with IN cord-023095-4dannjjm 1439 30 Salmonella Salmonella NNP cord-023095-4dannjjm 1439 31 sp sp NNP cord-023095-4dannjjm 1439 32 . . . cord-023095-4dannjjm 1440 1 is be VBZ cord-023095-4dannjjm 1440 2 a a DT cord-023095-4dannjjm 1440 3 serious serious JJ cord-023095-4dannjjm 1440 4 problem problem NN cord-023095-4dannjjm 1440 5 in in IN cord-023095-4dannjjm 1440 6 equine equine JJ cord-023095-4dannjjm 1440 7 hospitals hospital NNS cord-023095-4dannjjm 1440 8 . . . cord-023095-4dannjjm 1441 1 Salmonella salmonella NN cord-023095-4dannjjm 1441 2 sp sp NN cord-023095-4dannjjm 1441 3 . . . cord-023095-4dannjjm 1442 1 exposure exposure NN cord-023095-4dannjjm 1442 2 to to IN cord-023095-4dannjjm 1442 3 horses horse NNS cord-023095-4dannjjm 1442 4 in in IN cord-023095-4dannjjm 1442 5 the the DT cord-023095-4dannjjm 1442 6 facility facility NN cord-023095-4dannjjm 1442 7 can can MD cord-023095-4dannjjm 1442 8 result result VB cord-023095-4dannjjm 1442 9 in in IN cord-023095-4dannjjm 1442 10 nosocomial nosocomial JJ cord-023095-4dannjjm 1442 11 infections infection NNS cord-023095-4dannjjm 1442 12 which which WDT cord-023095-4dannjjm 1442 13 results result VBZ cord-023095-4dannjjm 1442 14 in in IN cord-023095-4dannjjm 1442 15 temporary temporary JJ cord-023095-4dannjjm 1442 16 facility facility NN cord-023095-4dannjjm 1442 17 closure closure NN cord-023095-4dannjjm 1442 18 , , , cord-023095-4dannjjm 1442 19 until until IN cord-023095-4dannjjm 1442 20 the the DT cord-023095-4dannjjm 1442 21 organism organism NN cord-023095-4dannjjm 1442 22 is be VBZ cord-023095-4dannjjm 1442 23 eradicated eradicate VBN cord-023095-4dannjjm 1442 24 . . . cord-023095-4dannjjm 1443 1 Hospital hospital NN cord-023095-4dannjjm 1443 2 closure closure NN cord-023095-4dannjjm 1443 3 can can MD cord-023095-4dannjjm 1443 4 result result VB cord-023095-4dannjjm 1443 5 in in IN cord-023095-4dannjjm 1443 6 loss loss NN cord-023095-4dannjjm 1443 7 of of IN cord-023095-4dannjjm 1443 8 revenue revenue NN cord-023095-4dannjjm 1443 9 , , , cord-023095-4dannjjm 1443 10 damage damage NN cord-023095-4dannjjm 1443 11 to to IN cord-023095-4dannjjm 1443 12 reputation reputation NN cord-023095-4dannjjm 1443 13 and and CC cord-023095-4dannjjm 1443 14 interference interference NN cord-023095-4dannjjm 1443 15 with with IN cord-023095-4dannjjm 1443 16 patient patient JJ cord-023095-4dannjjm 1443 17 care care NN cord-023095-4dannjjm 1443 18 . . . cord-023095-4dannjjm 1444 1 The the DT cord-023095-4dannjjm 1444 2 purpose purpose NN cord-023095-4dannjjm 1444 3 of of IN cord-023095-4dannjjm 1444 4 this this DT cord-023095-4dannjjm 1444 5 study study NN cord-023095-4dannjjm 1444 6 was be VBD cord-023095-4dannjjm 1444 7 to to TO cord-023095-4dannjjm 1444 8 evaluate evaluate VB cord-023095-4dannjjm 1444 9 three three CD cord-023095-4dannjjm 1444 10 stall stall NN cord-023095-4dannjjm 1444 11 cleaning cleaning NN cord-023095-4dannjjm 1444 12 methods method NNS cord-023095-4dannjjm 1444 13 on on IN cord-023095-4dannjjm 1444 14 eradication eradication NN cord-023095-4dannjjm 1444 15 of of IN cord-023095-4dannjjm 1444 16 Salmonella Salmonella NNP cord-023095-4dannjjm 1444 17 sp sp NNP cord-023095-4dannjjm 1444 18 . . . cord-023095-4dannjjm 1445 1 at at IN cord-023095-4dannjjm 1445 2 an an DT cord-023095-4dannjjm 1445 3 equine equine JJ cord-023095-4dannjjm 1445 4 veterinary veterinary JJ cord-023095-4dannjjm 1445 5 teaching teaching NN cord-023095-4dannjjm 1445 6 hospital hospital NN cord-023095-4dannjjm 1445 7 ( ( -LRB- cord-023095-4dannjjm 1445 8 VTH VTH NNP cord-023095-4dannjjm 1445 9 ) ) -RRB- cord-023095-4dannjjm 1445 10 . . . cord-023095-4dannjjm 1446 1 Horses horse NNS cord-023095-4dannjjm 1446 2 admitted admit VBD cord-023095-4dannjjm 1446 3 to to IN cord-023095-4dannjjm 1446 4 the the DT cord-023095-4dannjjm 1446 5 VTH VTH NNP cord-023095-4dannjjm 1446 6 were be VBD cord-023095-4dannjjm 1446 7 assigned assign VBN cord-023095-4dannjjm 1446 8 to to IN cord-023095-4dannjjm 1446 9 Salmonella Salmonella NNP cord-023095-4dannjjm 1446 10 sp.negative sp.negative NNP cord-023095-4dannjjm 1446 11 stalls stall NNS cord-023095-4dannjjm 1446 12 within within IN cord-023095-4dannjjm 1446 13 areas area NNS cord-023095-4dannjjm 1446 14 of of IN cord-023095-4dannjjm 1446 15 the the DT cord-023095-4dannjjm 1446 16 VTH VTH NNP cord-023095-4dannjjm 1446 17 during during IN cord-023095-4dannjjm 1446 18 the the DT cord-023095-4dannjjm 1446 19 study study NN cord-023095-4dannjjm 1446 20 period period NN cord-023095-4dannjjm 1446 21 ( ( -LRB- cord-023095-4dannjjm 1446 22 September September NNP cord-023095-4dannjjm 1446 23 2009 2009 CD cord-023095-4dannjjm 1446 24 -January -january SYM cord-023095-4dannjjm 1446 25 2010 2010 CD cord-023095-4dannjjm 1446 26 . . . cord-023095-4dannjjm 1447 1 When when WRB cord-023095-4dannjjm 1447 2 the the DT cord-023095-4dannjjm 1447 3 horses horse NNS cord-023095-4dannjjm 1447 4 were be VBD cord-023095-4dannjjm 1447 5 discharged discharge VBN cord-023095-4dannjjm 1447 6 stalls stall NNS cord-023095-4dannjjm 1447 7 were be VBD cord-023095-4dannjjm 1447 8 randomly randomly RB cord-023095-4dannjjm 1447 9 assigned assign VBN cord-023095-4dannjjm 1447 10 to to IN cord-023095-4dannjjm 1447 11 one one CD cord-023095-4dannjjm 1447 12 of of IN cord-023095-4dannjjm 1447 13 three three CD cord-023095-4dannjjm 1447 14 cleaning cleaning NN cord-023095-4dannjjm 1447 15 methods method NNS cord-023095-4dannjjm 1447 16 ( ( -LRB- cord-023095-4dannjjm 1447 17 pressure pressure NN cord-023095-4dannjjm 1447 18 - - HYPH cord-023095-4dannjjm 1447 19 washing wash VBG cord-023095-4dannjjm 1447 20 only only RB cord-023095-4dannjjm 1447 21 [ [ -LRB- cord-023095-4dannjjm 1447 22 PW pw NN cord-023095-4dannjjm 1447 23 ] ] -RRB- cord-023095-4dannjjm 1447 24 , , , cord-023095-4dannjjm 1447 25 pressure pressure NN cord-023095-4dannjjm 1447 26 washing washing NN cord-023095-4dannjjm 1447 27 and and CC cord-023095-4dannjjm 1447 28 hand hand NN cord-023095-4dannjjm 1447 29 scrubbing scrubbing NN cord-023095-4dannjjm 1447 30 [ [ -LRB- cord-023095-4dannjjm 1447 31 PWS PWS NNP cord-023095-4dannjjm 1447 32 ] ] -RRB- cord-023095-4dannjjm 1447 33 , , , cord-023095-4dannjjm 1447 34 or or CC cord-023095-4dannjjm 1447 35 hand hand NN cord-023095-4dannjjm 1447 36 scrubbing scrubbing NN cord-023095-4dannjjm 1447 37 only only RB cord-023095-4dannjjm 1447 38 [ [ -LRB- cord-023095-4dannjjm 1447 39 S S NNP cord-023095-4dannjjm 1447 40 ] ] -RRB- cord-023095-4dannjjm 1447 41 ) ) -RRB- cord-023095-4dannjjm 1447 42 in in IN cord-023095-4dannjjm 1447 43 a a DT cord-023095-4dannjjm 1447 44 single single JJ cord-023095-4dannjjm 1447 45 period period NN cord-023095-4dannjjm 1447 46 , , , cord-023095-4dannjjm 1447 47 non non JJ cord-023095-4dannjjm 1447 48 cross cross JJ cord-023095-4dannjjm 1447 49 - - HYPH cord-023095-4dannjjm 1447 50 over over RP cord-023095-4dannjjm 1447 51 design design NN cord-023095-4dannjjm 1447 52 . . . cord-023095-4dannjjm 1448 1 All all DT cord-023095-4dannjjm 1448 2 stalls stall NNS cord-023095-4dannjjm 1448 3 were be VBD cord-023095-4dannjjm 1448 4 stripped strip VBN cord-023095-4dannjjm 1448 5 of of IN cord-023095-4dannjjm 1448 6 bedding bedding NN cord-023095-4dannjjm 1448 7 and and CC cord-023095-4dannjjm 1448 8 surfaces surface NNS cord-023095-4dannjjm 1448 9 sprayed spray VBN cord-023095-4dannjjm 1448 10 with with IN cord-023095-4dannjjm 1448 11 tap tap NN cord-023095-4dannjjm 1448 12 water water NN cord-023095-4dannjjm 1448 13 and and CC cord-023095-4dannjjm 1448 14 cleaned clean VBD cord-023095-4dannjjm 1448 15 with with IN cord-023095-4dannjjm 1448 16 a a DT cord-023095-4dannjjm 1448 17 disinfectant disinfectant JJ cord-023095-4dannjjm 1448 18 quaternary quaternary NN cord-023095-4dannjjm 1448 19 - - HYPH cord-023095-4dannjjm 1448 20 ammonia ammonia NN cord-023095-4dannjjm 1448 21 solution solution NN cord-023095-4dannjjm 1448 22 ( ( -LRB- cord-023095-4dannjjm 1448 23 Super Super NNP cord-023095-4dannjjm 1448 24 HDQ HDQ NNP cord-023095-4dannjjm 1448 25 Neutral Neutral NNP cord-023095-4dannjjm 1448 26 , , , cord-023095-4dannjjm 1448 27 Spartan Spartan NNP cord-023095-4dannjjm 1448 28 Chemical Chemical NNP cord-023095-4dannjjm 1448 29 Co. Co. NNP cord-023095-4dannjjm 1448 30 , , , cord-023095-4dannjjm 1448 31 Inc Inc NNP cord-023095-4dannjjm 1448 32 , , , cord-023095-4dannjjm 1448 33 Maumee Maumee NNP cord-023095-4dannjjm 1448 34 , , , cord-023095-4dannjjm 1448 35 OH OH NNP cord-023095-4dannjjm 1448 36 ) ) -RRB- cord-023095-4dannjjm 1448 37 . . . cord-023095-4dannjjm 1449 1 The the DT cord-023095-4dannjjm 1449 2 pressure pressure NN cord-023095-4dannjjm 1449 3 - - HYPH cord-023095-4dannjjm 1449 4 washing wash VBG cord-023095-4dannjjm 1449 5 system system NN cord-023095-4dannjjm 1449 6 ( ( -LRB- cord-023095-4dannjjm 1449 7 PSC PSC NNP cord-023095-4dannjjm 1449 8 Cleaning Cleaning NNP cord-023095-4dannjjm 1449 9 Systems Systems NNPS cord-023095-4dannjjm 1449 10 , , , cord-023095-4dannjjm 1449 11 Inc. Inc. NNP cord-023095-4dannjjm 1449 12 , , , cord-023095-4dannjjm 1449 13 Toronto Toronto NNP cord-023095-4dannjjm 1449 14 , , , cord-023095-4dannjjm 1449 15 Canada Canada NNP cord-023095-4dannjjm 1449 16 ) ) -RRB- cord-023095-4dannjjm 1449 17 used use VBD cord-023095-4dannjjm 1449 18 , , , cord-023095-4dannjjm 1449 19 provided provide VBD cord-023095-4dannjjm 1449 20 a a DT cord-023095-4dannjjm 1449 21 pressure pressure NN cord-023095-4dannjjm 1449 22 of of IN cord-023095-4dannjjm 1449 23 3000 3000 CD cord-023095-4dannjjm 1449 24 psi psi NN cord-023095-4dannjjm 1449 25 and and CC cord-023095-4dannjjm 1449 26 a a DT cord-023095-4dannjjm 1449 27 temperature temperature NN cord-023095-4dannjjm 1449 28 range range NN cord-023095-4dannjjm 1449 29 of of IN cord-023095-4dannjjm 1449 30 1851 1851 CD cord-023095-4dannjjm 1449 31 - - SYM cord-023095-4dannjjm 1449 32 2151F. 2151f. CD cord-023095-4dannjjm 1450 1 Following follow VBG cord-023095-4dannjjm 1450 2 cleaning clean VBG cord-023095-4dannjjm 1450 3 , , , cord-023095-4dannjjm 1450 4 each each DT cord-023095-4dannjjm 1450 5 stall stall NN cord-023095-4dannjjm 1450 6 was be VBD cord-023095-4dannjjm 1450 7 allowed allow VBN cord-023095-4dannjjm 1450 8 to to TO cord-023095-4dannjjm 1450 9 air air NN cord-023095-4dannjjm 1450 10 dry dry JJ cord-023095-4dannjjm 1450 11 and and CC cord-023095-4dannjjm 1450 12 within within IN cord-023095-4dannjjm 1450 13 48 48 CD cord-023095-4dannjjm 1450 14 hours hour NNS cord-023095-4dannjjm 1450 15 , , , cord-023095-4dannjjm 1450 16 stall stall NN cord-023095-4dannjjm 1450 17 surfaces surface NNS cord-023095-4dannjjm 1450 18 were be VBD cord-023095-4dannjjm 1450 19 sampled sample VBN cord-023095-4dannjjm 1450 20 using use VBG cord-023095-4dannjjm 1450 21 three three CD cord-023095-4dannjjm 1450 22 4 4 CD cord-023095-4dannjjm 1450 23 00 00 CD cord-023095-4dannjjm 1450 24 Â â CD cord-023095-4dannjjm 1450 25 4 4 CD cord-023095-4dannjjm 1450 26 00 00 NFP cord-023095-4dannjjm 1450 27 sponges sponge NNS cord-023095-4dannjjm 1450 28 moistened moisten VBN cord-023095-4dannjjm 1450 29 with with IN cord-023095-4dannjjm 1450 30 sterile sterile JJ cord-023095-4dannjjm 1450 31 saline saline NN cord-023095-4dannjjm 1450 32 . . . cord-023095-4dannjjm 1451 1 The the DT cord-023095-4dannjjm 1451 2 person person NN cord-023095-4dannjjm 1451 3 collecting collect VBG cord-023095-4dannjjm 1451 4 the the DT cord-023095-4dannjjm 1451 5 samples sample NNS cord-023095-4dannjjm 1451 6 was be VBD cord-023095-4dannjjm 1451 7 masked mask VBN cord-023095-4dannjjm 1451 8 to to IN cord-023095-4dannjjm 1451 9 the the DT cord-023095-4dannjjm 1451 10 method method NN cord-023095-4dannjjm 1451 11 of of IN cord-023095-4dannjjm 1451 12 cleaning clean VBG cord-023095-4dannjjm 1451 13 . . . cord-023095-4dannjjm 1452 1 Sponges sponge NNS cord-023095-4dannjjm 1452 2 were be VBD cord-023095-4dannjjm 1452 3 submitted submit VBN cord-023095-4dannjjm 1452 4 to to IN cord-023095-4dannjjm 1452 5 the the DT cord-023095-4dannjjm 1452 6 Louisiana Louisiana NNP cord-023095-4dannjjm 1452 7 Animal Animal NNP cord-023095-4dannjjm 1452 8 Disease Disease NNP cord-023095-4dannjjm 1452 9 Diagnostic Diagnostic NNP cord-023095-4dannjjm 1452 10 Laboratory Laboratory NNP cord-023095-4dannjjm 1452 11 ( ( -LRB- cord-023095-4dannjjm 1452 12 LADDL LADDL NNP cord-023095-4dannjjm 1452 13 ) ) -RRB- cord-023095-4dannjjm 1452 14 for for IN cord-023095-4dannjjm 1452 15 culture culture NN cord-023095-4dannjjm 1452 16 of of IN cord-023095-4dannjjm 1452 17 Salmonella Salmonella NNP cord-023095-4dannjjm 1452 18 sp sp NNP cord-023095-4dannjjm 1452 19 . . . cord-023095-4dannjjm 1453 1 A a DT cord-023095-4dannjjm 1453 2 Chi Chi NNP cord-023095-4dannjjm 1453 3 - - HYPH cord-023095-4dannjjm 1453 4 Squared Squared NNP cord-023095-4dannjjm 1453 5 analysis analysis NN cord-023095-4dannjjm 1453 6 was be VBD cord-023095-4dannjjm 1453 7 used use VBN cord-023095-4dannjjm 1453 8 to to TO cord-023095-4dannjjm 1453 9 determine determine VB cord-023095-4dannjjm 1453 10 significant significant JJ cord-023095-4dannjjm 1453 11 differences difference NNS cord-023095-4dannjjm 1453 12 ( ( -LRB- cord-023095-4dannjjm 1453 13 limit limit NN cord-023095-4dannjjm 1453 14 p p NN cord-023095-4dannjjm 1453 15 o o NN cord-023095-4dannjjm 1453 16 0.05 0.05 CD cord-023095-4dannjjm 1453 17 ) ) -RRB- cord-023095-4dannjjm 1453 18 between between IN cord-023095-4dannjjm 1453 19 cleaning cleaning NN cord-023095-4dannjjm 1453 20 methods method NNS cord-023095-4dannjjm 1453 21 and and CC cord-023095-4dannjjm 1453 22 Salmonella Salmonella NNP cord-023095-4dannjjm 1453 23 sp sp NN cord-023095-4dannjjm 1453 24 . . . cord-023095-4dannjjm 1453 25 isolation isolation NN cord-023095-4dannjjm 1453 26 . . . cord-023095-4dannjjm 1454 1 During during IN cord-023095-4dannjjm 1454 2 the the DT cord-023095-4dannjjm 1454 3 study study NN cord-023095-4dannjjm 1454 4 period period NN cord-023095-4dannjjm 1454 5 , , , cord-023095-4dannjjm 1454 6 112 112 CD cord-023095-4dannjjm 1454 7 stalls stall NNS cord-023095-4dannjjm 1454 8 ( ( -LRB- cord-023095-4dannjjm 1454 9 PW pw NN cord-023095-4dannjjm 1454 10 [ [ -LRB- cord-023095-4dannjjm 1454 11 n n NN cord-023095-4dannjjm 1454 12 5 5 CD cord-023095-4dannjjm 1454 13 29 29 CD cord-023095-4dannjjm 1454 14 ] ] -RRB- cord-023095-4dannjjm 1454 15 ; ; : cord-023095-4dannjjm 1454 16 PWS PWS NNP cord-023095-4dannjjm 1454 17 [ [ -LRB- cord-023095-4dannjjm 1454 18 n n NN cord-023095-4dannjjm 1454 19 5 5 CD cord-023095-4dannjjm 1454 20 50 50 CD cord-023095-4dannjjm 1454 21 ] ] -RRB- cord-023095-4dannjjm 1454 22 ; ; : cord-023095-4dannjjm 1454 23 S S NNP cord-023095-4dannjjm 1454 24 [ [ -LRB- cord-023095-4dannjjm 1454 25 n n NN cord-023095-4dannjjm 1454 26 5 5 CD cord-023095-4dannjjm 1454 27 33 33 CD cord-023095-4dannjjm 1454 28 ] ] -RRB- cord-023095-4dannjjm 1454 29 were be VBD cord-023095-4dannjjm 1454 30 included include VBN cord-023095-4dannjjm 1454 31 . . . cord-023095-4dannjjm 1455 1 All all DT cord-023095-4dannjjm 1455 2 stalls stall NNS cord-023095-4dannjjm 1455 3 had have VBD cord-023095-4dannjjm 1455 4 negative negative JJ cord-023095-4dannjjm 1455 5 environmental environmental JJ cord-023095-4dannjjm 1455 6 salmonella salmonella NN cord-023095-4dannjjm 1455 7 sp sp NNP cord-023095-4dannjjm 1455 8 . . . cord-023095-4dannjjm 1456 1 cultures culture NNS cord-023095-4dannjjm 1456 2 prior prior RB cord-023095-4dannjjm 1456 3 to to IN cord-023095-4dannjjm 1456 4 beginning begin VBG cord-023095-4dannjjm 1456 5 the the DT cord-023095-4dannjjm 1456 6 study study NN cord-023095-4dannjjm 1456 7 . . . cord-023095-4dannjjm 1457 1 For for IN cord-023095-4dannjjm 1457 2 PW pw NN cord-023095-4dannjjm 1457 3 cleaned clean VBD cord-023095-4dannjjm 1457 4 stalls stall NNS cord-023095-4dannjjm 1457 5 , , , cord-023095-4dannjjm 1457 6 6/23 6/23 CD cord-023095-4dannjjm 1457 7 ( ( -LRB- cord-023095-4dannjjm 1457 8 20.7 20.7 CD cord-023095-4dannjjm 1457 9 % % NN cord-023095-4dannjjm 1457 10 ) ) -RRB- cord-023095-4dannjjm 1457 11 were be VBD cord-023095-4dannjjm 1457 12 Salmonella Salmonella NNP cord-023095-4dannjjm 1457 13 sp.-positive sp.-positive NNP cord-023095-4dannjjm 1457 14 , , , cord-023095-4dannjjm 1457 15 for for IN cord-023095-4dannjjm 1457 16 PWS PWS NNP cord-023095-4dannjjm 1457 17 cleaned clean VBD cord-023095-4dannjjm 1457 18 stalls stall NNS cord-023095-4dannjjm 1457 19 , , , cord-023095-4dannjjm 1457 20 12/38 12/38 CD cord-023095-4dannjjm 1457 21 ( ( -LRB- cord-023095-4dannjjm 1457 22 24 24 CD cord-023095-4dannjjm 1457 23 % % NN cord-023095-4dannjjm 1457 24 ) ) -RRB- cord-023095-4dannjjm 1457 25 were be VBD cord-023095-4dannjjm 1457 26 Salmonella Salmonella NNP cord-023095-4dannjjm 1457 27 sp.-positive sp.-positive NNP cord-023095-4dannjjm 1457 28 , , , cord-023095-4dannjjm 1457 29 and and CC cord-023095-4dannjjm 1457 30 for for IN cord-023095-4dannjjm 1457 31 S S NNP cord-023095-4dannjjm 1457 32 cleaned clean VBD cord-023095-4dannjjm 1457 33 stalls stall NNS cord-023095-4dannjjm 1457 34 , , , cord-023095-4dannjjm 1457 35 4/29 4/29 CD cord-023095-4dannjjm 1457 36 ( ( -LRB- cord-023095-4dannjjm 1457 37 12.1 12.1 CD cord-023095-4dannjjm 1457 38 % % NN cord-023095-4dannjjm 1457 39 ) ) -RRB- cord-023095-4dannjjm 1457 40 were be VBD cord-023095-4dannjjm 1457 41 Salmonella Salmonella NNP cord-023095-4dannjjm 1457 42 sp.-positive sp.-positive NNP cord-023095-4dannjjm 1457 43 . . . cord-023095-4dannjjm 1458 1 Although although IN cord-023095-4dannjjm 1458 2 , , , cord-023095-4dannjjm 1458 3 there there EX cord-023095-4dannjjm 1458 4 were be VBD cord-023095-4dannjjm 1458 5 fewer few JJR cord-023095-4dannjjm 1458 6 Salmonella Salmonella NNP cord-023095-4dannjjm 1458 7 sp.-positive sp.-positive JJ cord-023095-4dannjjm 1458 8 stalls stall NNS cord-023095-4dannjjm 1458 9 ( ( -LRB- cord-023095-4dannjjm 1458 10 12.1 12.1 CD cord-023095-4dannjjm 1458 11 % % NN cord-023095-4dannjjm 1458 12 ) ) -RRB- cord-023095-4dannjjm 1458 13 in in IN cord-023095-4dannjjm 1458 14 the the DT cord-023095-4dannjjm 1458 15 handscrubbed handscrubbed NNP cord-023095-4dannjjm 1458 16 stalls stall NNS cord-023095-4dannjjm 1458 17 , , , cord-023095-4dannjjm 1458 18 cleaning cleaning NN cord-023095-4dannjjm 1458 19 method method NN cord-023095-4dannjjm 1458 20 did do VBD cord-023095-4dannjjm 1458 21 not not RB cord-023095-4dannjjm 1458 22 significantly significantly RB cord-023095-4dannjjm 1458 23 ( ( -LRB- cord-023095-4dannjjm 1458 24 p p NN cord-023095-4dannjjm 1458 25 5 5 CD cord-023095-4dannjjm 1458 26 0.4057 0.4057 CD cord-023095-4dannjjm 1458 27 ) ) -RRB- cord-023095-4dannjjm 1458 28 affect affect VB cord-023095-4dannjjm 1458 29 the the DT cord-023095-4dannjjm 1458 30 isolation isolation NN cord-023095-4dannjjm 1458 31 of of IN cord-023095-4dannjjm 1458 32 Salmonella Salmonella NNP cord-023095-4dannjjm 1458 33 sp sp NNP cord-023095-4dannjjm 1458 34 . . . cord-023095-4dannjjm 1459 1 from from IN cord-023095-4dannjjm 1459 2 the the DT cord-023095-4dannjjm 1459 3 stall stall JJ cord-023095-4dannjjm 1459 4 environment environment NN cord-023095-4dannjjm 1459 5 . . . cord-023095-4dannjjm 1460 1 In in IN cord-023095-4dannjjm 1460 2 conclusion conclusion NN cord-023095-4dannjjm 1460 3 , , , cord-023095-4dannjjm 1460 4 power power NN cord-023095-4dannjjm 1460 5 washing washing NN cord-023095-4dannjjm 1460 6 alone alone RB cord-023095-4dannjjm 1460 7 , , , cord-023095-4dannjjm 1460 8 power power NN cord-023095-4dannjjm 1460 9 washing washing NN cord-023095-4dannjjm 1460 10 and and CC cord-023095-4dannjjm 1460 11 hand hand NN cord-023095-4dannjjm 1460 12 scrubbing scrubbing NN cord-023095-4dannjjm 1460 13 , , , cord-023095-4dannjjm 1460 14 and and CC cord-023095-4dannjjm 1460 15 hand hand NN cord-023095-4dannjjm 1460 16 scrubbing scrubbing NN cord-023095-4dannjjm 1460 17 alone alone RB cord-023095-4dannjjm 1460 18 , , , cord-023095-4dannjjm 1460 19 using use VBG cord-023095-4dannjjm 1460 20 a a DT cord-023095-4dannjjm 1460 21 quaternary quaternary JJ cord-023095-4dannjjm 1460 22 - - HYPH cord-023095-4dannjjm 1460 23 ammonia ammonia NN cord-023095-4dannjjm 1460 24 solution solution NN cord-023095-4dannjjm 1460 25 did do VBD cord-023095-4dannjjm 1460 26 not not RB cord-023095-4dannjjm 1460 27 significantly significantly RB cord-023095-4dannjjm 1460 28 affect affect VB cord-023095-4dannjjm 1460 29 environmental environmental JJ cord-023095-4dannjjm 1460 30 isolation isolation NN cord-023095-4dannjjm 1460 31 of of IN cord-023095-4dannjjm 1460 32 Salmonella Salmonella NNP cord-023095-4dannjjm 1460 33 sp sp NNP cord-023095-4dannjjm 1460 34 . . . cord-023095-4dannjjm 1461 1 from from IN cord-023095-4dannjjm 1461 2 stalls stall NNS cord-023095-4dannjjm 1461 3 surfaces surface NNS cord-023095-4dannjjm 1461 4 in in IN cord-023095-4dannjjm 1461 5 the the DT cord-023095-4dannjjm 1461 6 VTH VTH NNP cord-023095-4dannjjm 1461 7 during during IN cord-023095-4dannjjm 1461 8 this this DT cord-023095-4dannjjm 1461 9 study study NN cord-023095-4dannjjm 1461 10 . . . cord-023095-4dannjjm 1462 1 The the DT cord-023095-4dannjjm 1462 2 objectives objective NNS cord-023095-4dannjjm 1462 3 of of IN cord-023095-4dannjjm 1462 4 this this DT cord-023095-4dannjjm 1462 5 study study NN cord-023095-4dannjjm 1462 6 were be VBD cord-023095-4dannjjm 1462 7 to to TO cord-023095-4dannjjm 1462 8 determine determine VB cord-023095-4dannjjm 1462 9 the the DT cord-023095-4dannjjm 1462 10 plasma plasma NN cord-023095-4dannjjm 1462 11 and and CC cord-023095-4dannjjm 1462 12 pulmonary pulmonary JJ cord-023095-4dannjjm 1462 13 disposition disposition NN cord-023095-4dannjjm 1462 14 of of IN cord-023095-4dannjjm 1462 15 gamithromycin gamithromycin NNS cord-023095-4dannjjm 1462 16 in in IN cord-023095-4dannjjm 1462 17 foals foal NNS cord-023095-4dannjjm 1462 18 and and CC cord-023095-4dannjjm 1462 19 to to TO cord-023095-4dannjjm 1462 20 investigate investigate VB cord-023095-4dannjjm 1462 21 the the DT cord-023095-4dannjjm 1462 22 in in FW cord-023095-4dannjjm 1462 23 vitro vitro FW cord-023095-4dannjjm 1462 24 activity activity NN cord-023095-4dannjjm 1462 25 of of IN cord-023095-4dannjjm 1462 26 the the DT cord-023095-4dannjjm 1462 27 drug drug NN cord-023095-4dannjjm 1462 28 against against IN cord-023095-4dannjjm 1462 29 Streptococcus streptococcus NN cord-023095-4dannjjm 1462 30 equi equi NN cord-023095-4dannjjm 1462 31 subsp subsp NN cord-023095-4dannjjm 1462 32 . . . cord-023095-4dannjjm 1463 1 zooepidemicus zooepidemicus NNP cord-023095-4dannjjm 1463 2 ( ( -LRB- cord-023095-4dannjjm 1463 3 S. S. NNP cord-023095-4dannjjm 1463 4 zooepidemicus zooepidemicus NNP cord-023095-4dannjjm 1463 5 ) ) -RRB- cord-023095-4dannjjm 1463 6 and and CC cord-023095-4dannjjm 1463 7 Rhodococcus Rhodococcus NNP cord-023095-4dannjjm 1463 8 equi equi NN cord-023095-4dannjjm 1463 9 isolates isolate NNS cord-023095-4dannjjm 1463 10 . . . cord-023095-4dannjjm 1464 1 A a DT cord-023095-4dannjjm 1464 2 single single JJ cord-023095-4dannjjm 1464 3 dose dose NN cord-023095-4dannjjm 1464 4 of of IN cord-023095-4dannjjm 1464 5 gamithromycin gamithromycin NNS cord-023095-4dannjjm 1464 6 ( ( -LRB- cord-023095-4dannjjm 1464 7 6 6 CD cord-023095-4dannjjm 1464 8 mg mg NNP cord-023095-4dannjjm 1464 9 / / SYM cord-023095-4dannjjm 1464 10 kg kg NNS cord-023095-4dannjjm 1464 11 of of IN cord-023095-4dannjjm 1464 12 body body NN cord-023095-4dannjjm 1464 13 weight weight NN cord-023095-4dannjjm 1464 14 ) ) -RRB- cord-023095-4dannjjm 1464 15 was be VBD cord-023095-4dannjjm 1464 16 administered administer VBN cord-023095-4dannjjm 1464 17 intramuscularly intramuscularly RB cord-023095-4dannjjm 1464 18 . . . cord-023095-4dannjjm 1465 1 Concentrations concentration NNS cord-023095-4dannjjm 1465 2 of of IN cord-023095-4dannjjm 1465 3 gamithromycin gamithromycin NNS cord-023095-4dannjjm 1465 4 in in IN cord-023095-4dannjjm 1465 5 plasma plasma NN cord-023095-4dannjjm 1465 6 , , , cord-023095-4dannjjm 1465 7 pulmonary pulmonary JJ cord-023095-4dannjjm 1465 8 epithelial epithelial JJ cord-023095-4dannjjm 1465 9 lining lining NN cord-023095-4dannjjm 1465 10 fluid fluid NN cord-023095-4dannjjm 1465 11 ( ( -LRB- cord-023095-4dannjjm 1465 12 PELF PELF NNP cord-023095-4dannjjm 1465 13 ) ) -RRB- cord-023095-4dannjjm 1465 14 , , , cord-023095-4dannjjm 1465 15 bronchoalveolar bronchoalveolar NNP cord-023095-4dannjjm 1465 16 lavage lavage NNP cord-023095-4dannjjm 1465 17 ( ( -LRB- cord-023095-4dannjjm 1465 18 BAL BAL NNP cord-023095-4dannjjm 1465 19 ) ) -RRB- cord-023095-4dannjjm 1465 20 cells cell NNS cord-023095-4dannjjm 1465 21 , , , cord-023095-4dannjjm 1465 22 and and CC cord-023095-4dannjjm 1465 23 blood blood NN cord-023095-4dannjjm 1465 24 neutrophils neutrophil NNS cord-023095-4dannjjm 1465 25 were be VBD cord-023095-4dannjjm 1465 26 determined determine VBN cord-023095-4dannjjm 1465 27 using use VBG cord-023095-4dannjjm 1465 28 HPLC HPLC NNP cord-023095-4dannjjm 1465 29 with with IN cord-023095-4dannjjm 1465 30 tandem tandem JJ cord-023095-4dannjjm 1465 31 mass mass NN cord-023095-4dannjjm 1465 32 spectrometry spectrometry NN cord-023095-4dannjjm 1465 33 detection detection NN cord-023095-4dannjjm 1465 34 . . . cord-023095-4dannjjm 1466 1 The the DT cord-023095-4dannjjm 1466 2 minimum minimum JJ cord-023095-4dannjjm 1466 3 inhibitory inhibitory JJ cord-023095-4dannjjm 1466 4 concentration concentration NN cord-023095-4dannjjm 1466 5 of of IN cord-023095-4dannjjm 1466 6 gamithromycin gamithromycin NNS cord-023095-4dannjjm 1466 7 required require VBN cord-023095-4dannjjm 1466 8 to to TO cord-023095-4dannjjm 1466 9 inhibit inhibit VB cord-023095-4dannjjm 1466 10 growth growth NN cord-023095-4dannjjm 1466 11 of of IN cord-023095-4dannjjm 1466 12 90 90 CD cord-023095-4dannjjm 1466 13 % % NN cord-023095-4dannjjm 1466 14 of of IN cord-023095-4dannjjm 1466 15 R. R. NNP cord-023095-4dannjjm 1466 16 equi equi NN cord-023095-4dannjjm 1466 17 and and CC cord-023095-4dannjjm 1466 18 S. S. NNP cord-023095-4dannjjm 1466 19 zooepidemicus zooepidemicus NNP cord-023095-4dannjjm 1466 20 isolates isolate VBZ cord-023095-4dannjjm 1466 21 ( ( -LRB- cord-023095-4dannjjm 1466 22 MIC MIC NNP cord-023095-4dannjjm 1466 23 90 90 CD cord-023095-4dannjjm 1466 24 ) ) -RRB- cord-023095-4dannjjm 1466 25 was be VBD cord-023095-4dannjjm 1466 26 determined determine VBN cord-023095-4dannjjm 1466 27 . . . cord-023095-4dannjjm 1467 1 Additionally additionally RB cord-023095-4dannjjm 1467 2 , , , cord-023095-4dannjjm 1467 3 the the DT cord-023095-4dannjjm 1467 4 activity activity NN cord-023095-4dannjjm 1467 5 of of IN cord-023095-4dannjjm 1467 6 gamithromycin gamithromycin NNS cord-023095-4dannjjm 1467 7 against against IN cord-023095-4dannjjm 1467 8 intracellular intracellular JJ cord-023095-4dannjjm 1467 9 R. R. NNP cord-023095-4dannjjm 1467 10 equi equi NN cord-023095-4dannjjm 1467 11 was be VBD cord-023095-4dannjjm 1467 12 measured measure VBN cord-023095-4dannjjm 1467 13 . . . cord-023095-4dannjjm 1468 1 Mean mean JJ cord-023095-4dannjjm 1468 2 peak peak NN cord-023095-4dannjjm 1468 3 gamithromycin gamithromycin NNS cord-023095-4dannjjm 1468 4 concentrations concentration NNS cord-023095-4dannjjm 1468 5 were be VBD cord-023095-4dannjjm 1468 6 significantly significantly RB cord-023095-4dannjjm 1468 7 higher high JJR cord-023095-4dannjjm 1468 8 in in IN cord-023095-4dannjjm 1468 9 blood blood NN cord-023095-4dannjjm 1468 10 neutrophils neutrophil NNS cord-023095-4dannjjm 1468 11 ( ( -LRB- cord-023095-4dannjjm 1468 12 8.35 8.35 CD cord-023095-4dannjjm 1468 13 AE AE NNP cord-023095-4dannjjm 1468 14 1.77 1.77 CD cord-023095-4dannjjm 1468 15 g g NN cord-023095-4dannjjm 1468 16 / / SYM cord-023095-4dannjjm 1468 17 mL mL NNP cord-023095-4dannjjm 1468 18 ) ) -RRB- cord-023095-4dannjjm 1468 19 and and CC cord-023095-4dannjjm 1468 20 BAL bal NN cord-023095-4dannjjm 1468 21 cells cell NNS cord-023095-4dannjjm 1468 22 ( ( -LRB- cord-023095-4dannjjm 1468 23 8.91 8.91 CD cord-023095-4dannjjm 1468 24 AE AE NNP cord-023095-4dannjjm 1468 25 1.65 1.65 CD cord-023095-4dannjjm 1468 26 g g NN cord-023095-4dannjjm 1468 27 / / SYM cord-023095-4dannjjm 1468 28 mL ml NN cord-023095-4dannjjm 1468 29 ) ) -RRB- cord-023095-4dannjjm 1468 30 compared compare VBN cord-023095-4dannjjm 1468 31 to to IN cord-023095-4dannjjm 1468 32 PELF PELF NNP cord-023095-4dannjjm 1468 33 ( ( -LRB- cord-023095-4dannjjm 1468 34 2.15 2.15 CD cord-023095-4dannjjm 1468 35 AE AE NNP cord-023095-4dannjjm 1468 36 2.78 2.78 CD cord-023095-4dannjjm 1468 37 g g NN cord-023095-4dannjjm 1468 38 / / SYM cord-023095-4dannjjm 1468 39 mL mL NNP cord-023095-4dannjjm 1468 40 ) ) -RRB- cord-023095-4dannjjm 1468 41 and and CC cord-023095-4dannjjm 1468 42 plasma plasma NN cord-023095-4dannjjm 1468 43 ( ( -LRB- cord-023095-4dannjjm 1468 44 0.33 0.33 CD cord-023095-4dannjjm 1468 45 AE AE NNP cord-023095-4dannjjm 1468 46 0.12 0.12 CD cord-023095-4dannjjm 1468 47 g g NN cord-023095-4dannjjm 1468 48 / / SYM cord-023095-4dannjjm 1468 49 mL mL NNP cord-023095-4dannjjm 1468 50 ) ) -RRB- cord-023095-4dannjjm 1468 51 . . . cord-023095-4dannjjm 1469 1 Mean mean JJ cord-023095-4dannjjm 1469 2 terminal terminal JJ cord-023095-4dannjjm 1469 3 half half RB cord-023095-4dannjjm 1469 4 - - HYPH cord-023095-4dannjjm 1469 5 lives life NNS cord-023095-4dannjjm 1469 6 in in IN cord-023095-4dannjjm 1469 7 neutrophils neutrophil NNS cord-023095-4dannjjm 1469 8 ( ( -LRB- cord-023095-4dannjjm 1469 9 78.6 78.6 CD cord-023095-4dannjjm 1469 10 h h NN cord-023095-4dannjjm 1469 11 ) ) -RRB- cord-023095-4dannjjm 1470 1 , , , cord-023095-4dannjjm 1470 2 BAL BAL NNP cord-023095-4dannjjm 1470 3 cells cell NNS cord-023095-4dannjjm 1470 4 ( ( -LRB- cord-023095-4dannjjm 1470 5 70.3 70.3 CD cord-023095-4dannjjm 1470 6 h h NNP cord-023095-4dannjjm 1470 7 ) ) -RRB- cord-023095-4dannjjm 1470 8 , , , cord-023095-4dannjjm 1470 9 and and CC cord-023095-4dannjjm 1470 10 PELF PELF NNP cord-023095-4dannjjm 1470 11 ( ( -LRB- cord-023095-4dannjjm 1470 12 63.6 63.6 CD cord-023095-4dannjjm 1470 13 h h NN cord-023095-4dannjjm 1470 14 ) ) -RRB- cord-023095-4dannjjm 1470 15 were be VBD cord-023095-4dannjjm 1470 16 significantly significantly RB cord-023095-4dannjjm 1470 17 longer long JJR cord-023095-4dannjjm 1470 18 than than IN cord-023095-4dannjjm 1470 19 that that DT cord-023095-4dannjjm 1470 20 of of IN cord-023095-4dannjjm 1470 21 plasma plasma NN cord-023095-4dannjjm 1470 22 ( ( -LRB- cord-023095-4dannjjm 1470 23 39.1 39.1 CD cord-023095-4dannjjm 1470 24 h h NN cord-023095-4dannjjm 1470 25 ) ) -RRB- cord-023095-4dannjjm 1470 26 . . . cord-023095-4dannjjm 1471 1 The the DT cord-023095-4dannjjm 1471 2 MIC MIC NNP cord-023095-4dannjjm 1471 3 90 90 CD cord-023095-4dannjjm 1471 4 of of IN cord-023095-4dannjjm 1471 5 S. S. NNP cord-023095-4dannjjm 1471 6 zooepidemicus zooepidemicus NNP cord-023095-4dannjjm 1471 7 isolates isolates NNP cord-023095-4dannjjm 1471 8 was be VBD cord-023095-4dannjjm 1471 9 0.125 0.125 CD cord-023095-4dannjjm 1471 10 g g NN cord-023095-4dannjjm 1471 11 / / SYM cord-023095-4dannjjm 1471 12 mL. mL. NNP cord-023095-4dannjjm 1472 1 The the DT cord-023095-4dannjjm 1472 2 MIC MIC NNP cord-023095-4dannjjm 1472 3 90 90 CD cord-023095-4dannjjm 1472 4 of of IN cord-023095-4dannjjm 1472 5 gamithromycin gamithromycin NNS cord-023095-4dannjjm 1472 6 for for IN cord-023095-4dannjjm 1472 7 macrolide macrolide JJ cord-023095-4dannjjm 1472 8 - - HYPH cord-023095-4dannjjm 1472 9 resistant resistant JJ cord-023095-4dannjjm 1472 10 R. R. NNP cord-023095-4dannjjm 1472 11 equi equi NN cord-023095-4dannjjm 1472 12 isolates isolate NNS cord-023095-4dannjjm 1472 13 ( ( -LRB- cord-023095-4dannjjm 1472 14 128 128 CD cord-023095-4dannjjm 1472 15 g g NN cord-023095-4dannjjm 1472 16 / / SYM cord-023095-4dannjjm 1472 17 mL ml NN cord-023095-4dannjjm 1472 18 ) ) -RRB- cord-023095-4dannjjm 1472 19 was be VBD cord-023095-4dannjjm 1472 20 significantly significantly RB cord-023095-4dannjjm 1472 21 higher high JJR cord-023095-4dannjjm 1472 22 than than IN cord-023095-4dannjjm 1472 23 that that DT cord-023095-4dannjjm 1472 24 of of IN cord-023095-4dannjjm 1472 25 macrolide macrolide NN cord-023095-4dannjjm 1472 26 - - HYPH cord-023095-4dannjjm 1472 27 susceptible susceptible JJ cord-023095-4dannjjm 1472 28 isolates isolate NNS cord-023095-4dannjjm 1472 29 ( ( -LRB- cord-023095-4dannjjm 1472 30 1.0g/ 1.0g/ CD cord-023095-4dannjjm 1472 31 mL ml NN cord-023095-4dannjjm 1472 32 ) ) -RRB- cord-023095-4dannjjm 1472 33 . . . cord-023095-4dannjjm 1473 1 The the DT cord-023095-4dannjjm 1473 2 activity activity NN cord-023095-4dannjjm 1473 3 of of IN cord-023095-4dannjjm 1473 4 gamithromycin gamithromycin NNS cord-023095-4dannjjm 1473 5 against against IN cord-023095-4dannjjm 1473 6 intracellular intracellular JJ cord-023095-4dannjjm 1473 7 R. R. NNP cord-023095-4dannjjm 1473 8 equi equi NN cord-023095-4dannjjm 1473 9 was be VBD cord-023095-4dannjjm 1473 10 similar similar JJ cord-023095-4dannjjm 1473 11 to to IN cord-023095-4dannjjm 1473 12 that that DT cord-023095-4dannjjm 1473 13 of of IN cord-023095-4dannjjm 1473 14 azithromycin azithromycin NN cord-023095-4dannjjm 1473 15 and and CC cord-023095-4dannjjm 1473 16 erythromycin erythromycin NN cord-023095-4dannjjm 1473 17 . . . cord-023095-4dannjjm 1474 1 Intramuscular intramuscular JJ cord-023095-4dannjjm 1474 2 administration administration NN cord-023095-4dannjjm 1474 3 of of IN cord-023095-4dannjjm 1474 4 gamithromycin gamithromycin NNS cord-023095-4dannjjm 1474 5 at at IN cord-023095-4dannjjm 1474 6 a a DT cord-023095-4dannjjm 1474 7 dosage dosage NN cord-023095-4dannjjm 1474 8 of of IN cord-023095-4dannjjm 1474 9 6 6 CD cord-023095-4dannjjm 1474 10 mg mg NNP cord-023095-4dannjjm 1474 11 / / SYM cord-023095-4dannjjm 1474 12 kg kg NNS cord-023095-4dannjjm 1474 13 would would MD cord-023095-4dannjjm 1474 14 maintain maintain VB cord-023095-4dannjjm 1474 15 PELF PELF NNP cord-023095-4dannjjm 1474 16 concentrations concentration NNS cord-023095-4dannjjm 1474 17 above above IN cord-023095-4dannjjm 1474 18 the the DT cord-023095-4dannjjm 1474 19 MIC MIC NNP cord-023095-4dannjjm 1474 20 90 90 CD cord-023095-4dannjjm 1474 21 for for IN cord-023095-4dannjjm 1474 22 S. S. NNP cord-023095-4dannjjm 1474 23 zooepidemicus zooepidemicus NNP cord-023095-4dannjjm 1474 24 and and CC cord-023095-4dannjjm 1474 25 phagocytic phagocytic JJ cord-023095-4dannjjm 1474 26 cell cell NN cord-023095-4dannjjm 1474 27 concentrations concentration NNS cord-023095-4dannjjm 1474 28 above above IN cord-023095-4dannjjm 1474 29 the the DT cord-023095-4dannjjm 1474 30 MIC MIC NNP cord-023095-4dannjjm 1474 31 90 90 CD cord-023095-4dannjjm 1474 32 for for IN cord-023095-4dannjjm 1474 33 R. R. NNP cord-023095-4dannjjm 1474 34 equi equi NN cord-023095-4dannjjm 1474 35 for for IN cord-023095-4dannjjm 1474 36 approximately approximately RB cord-023095-4dannjjm 1474 37 7 7 CD cord-023095-4dannjjm 1474 38 days day NNS cord-023095-4dannjjm 1474 39 . . . cord-023095-4dannjjm 1475 1 Eight eight CD cord-023095-4dannjjm 1475 2 Western western JJ cord-023095-4dannjjm 1475 3 stock stock NN cord-023095-4dannjjm 1475 4 yearling yearling NN cord-023095-4dannjjm 1475 5 horses horse NNS cord-023095-4dannjjm 1475 6 were be VBD cord-023095-4dannjjm 1475 7 infected infect VBN cord-023095-4dannjjm 1475 8 with with IN cord-023095-4dannjjm 1475 9 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1475 10 ( ( -LRB- cord-023095-4dannjjm 1475 11 Ab4 ab4 NN cord-023095-4dannjjm 1475 12 ) ) -RRB- cord-023095-4dannjjm 1475 13 by by IN cord-023095-4dannjjm 1475 14 nasopharyngeal nasopharyngeal JJ cord-023095-4dannjjm 1475 15 instillation instillation NN cord-023095-4dannjjm 1475 16 . . . cord-023095-4dannjjm 1476 1 Venous venous JJ cord-023095-4dannjjm 1476 2 blood blood NN cord-023095-4dannjjm 1476 3 samples sample NNS cord-023095-4dannjjm 1476 4 for for IN cord-023095-4dannjjm 1476 5 collection collection NN cord-023095-4dannjjm 1476 6 of of IN cord-023095-4dannjjm 1476 7 plasma plasma NN cord-023095-4dannjjm 1476 8 were be VBD cord-023095-4dannjjm 1476 9 collected collect VBN cord-023095-4dannjjm 1476 10 in in IN cord-023095-4dannjjm 1476 11 Na Na NNP cord-023095-4dannjjm 1476 12 - - HYPH cord-023095-4dannjjm 1476 13 citrate citrate NN cord-023095-4dannjjm 1476 14 tubes tube NNS cord-023095-4dannjjm 1476 15 on on IN cord-023095-4dannjjm 1476 16 the the DT cord-023095-4dannjjm 1476 17 day day NN cord-023095-4dannjjm 1476 18 prior prior RB cord-023095-4dannjjm 1476 19 to to IN cord-023095-4dannjjm 1476 20 infection infection NN cord-023095-4dannjjm 1476 21 ( ( -LRB- cord-023095-4dannjjm 1476 22 D D NNP cord-023095-4dannjjm 1476 23 -1 -1 NN cord-023095-4dannjjm 1476 24 ) ) -RRB- cord-023095-4dannjjm 1476 25 and and CC cord-023095-4dannjjm 1476 26 on on IN cord-023095-4dannjjm 1476 27 D4 d4 NN cord-023095-4dannjjm 1476 28 through through IN cord-023095-4dannjjm 1476 29 D11 D11 NNP cord-023095-4dannjjm 1476 30 . . . cord-023095-4dannjjm 1477 1 In in IN cord-023095-4dannjjm 1477 2 addition addition NN cord-023095-4dannjjm 1477 3 , , , cord-023095-4dannjjm 1477 4 clinical clinical JJ cord-023095-4dannjjm 1477 5 data datum NNS cord-023095-4dannjjm 1477 6 , , , cord-023095-4dannjjm 1477 7 nasal nasal NN cord-023095-4dannjjm 1477 8 swabs swab NNS cord-023095-4dannjjm 1477 9 and and CC cord-023095-4dannjjm 1477 10 peripheral peripheral JJ cord-023095-4dannjjm 1477 11 blood blood NN cord-023095-4dannjjm 1477 12 mononuclear mononuclear NN cord-023095-4dannjjm 1477 13 cells cell NNS cord-023095-4dannjjm 1477 14 ( ( -LRB- cord-023095-4dannjjm 1477 15 PBMC PBMC NNP cord-023095-4dannjjm 1477 16 ) ) -RRB- cord-023095-4dannjjm 1477 17 for for IN cord-023095-4dannjjm 1477 18 detection detection NN cord-023095-4dannjjm 1477 19 of of IN cord-023095-4dannjjm 1477 20 viremia viremia NN cord-023095-4dannjjm 1477 21 were be VBD cord-023095-4dannjjm 1477 22 collected collect VBN cord-023095-4dannjjm 1477 23 on on IN cord-023095-4dannjjm 1477 24 the the DT cord-023095-4dannjjm 1477 25 day day NN cord-023095-4dannjjm 1477 26 before before IN cord-023095-4dannjjm 1477 27 infection infection NN cord-023095-4dannjjm 1477 28 ( ( -LRB- cord-023095-4dannjjm 1477 29 D D NNP cord-023095-4dannjjm 1477 30 -1 -1 NN cord-023095-4dannjjm 1477 31 ) ) -RRB- cord-023095-4dannjjm 1477 32 and and CC cord-023095-4dannjjm 1477 33 on on IN cord-023095-4dannjjm 1477 34 D1 d1 NN cord-023095-4dannjjm 1477 35 through through IN cord-023095-4dannjjm 1477 36 D14 D14 NNP cord-023095-4dannjjm 1477 37 post post NN cord-023095-4dannjjm 1477 38 - - NN cord-023095-4dannjjm 1477 39 infection infection NN cord-023095-4dannjjm 1477 40 . . . cord-023095-4dannjjm 1478 1 D d NN cord-023095-4dannjjm 1478 2 - - HYPH cord-023095-4dannjjm 1478 3 dimer dimer NN cord-023095-4dannjjm 1478 4 concentrations concentration NNS cord-023095-4dannjjm 1478 5 were be VBD cord-023095-4dannjjm 1478 6 determined determine VBN cord-023095-4dannjjm 1478 7 in in IN cord-023095-4dannjjm 1478 8 citrated citrate VBN cord-023095-4dannjjm 1478 9 plasma plasma NN cord-023095-4dannjjm 1478 10 samples sample NNS cord-023095-4dannjjm 1478 11 using use VBG cord-023095-4dannjjm 1478 12 a a DT cord-023095-4dannjjm 1478 13 latex latex NN cord-023095-4dannjjm 1478 14 agglutination agglutination NN cord-023095-4dannjjm 1478 15 test test NN cord-023095-4dannjjm 1478 16 ( ( -LRB- cord-023095-4dannjjm 1478 17 Minutex Minutex NNP cord-023095-4dannjjm 1478 18 D D NNP cord-023095-4dannjjm 1478 19 - - HYPH cord-023095-4dannjjm 1478 20 dimer dimer NN cord-023095-4dannjjm 1478 21 , , , cord-023095-4dannjjm 1478 22 biopool biopool NN cord-023095-4dannjjm 1478 23 , , , cord-023095-4dannjjm 1478 24 Ireland Ireland NNP cord-023095-4dannjjm 1478 25 ) ) -RRB- cord-023095-4dannjjm 1478 26 . . . cord-023095-4dannjjm 1479 1 Viral viral JJ cord-023095-4dannjjm 1479 2 load load NN cord-023095-4dannjjm 1479 3 in in IN cord-023095-4dannjjm 1479 4 PBMC PBMC NNP cord-023095-4dannjjm 1479 5 was be VBD cord-023095-4dannjjm 1479 6 determined determine VBN cord-023095-4dannjjm 1479 7 using use VBG cord-023095-4dannjjm 1479 8 quantitative quantitative JJ cord-023095-4dannjjm 1479 9 PCR PCR NNP cord-023095-4dannjjm 1479 10 . . . cord-023095-4dannjjm 1480 1 All all DT cord-023095-4dannjjm 1480 2 horses horse NNS cord-023095-4dannjjm 1480 3 showed show VBD cord-023095-4dannjjm 1480 4 bi bi JJ cord-023095-4dannjjm 1480 5 - - JJ cord-023095-4dannjjm 1480 6 phasic phasic JJ cord-023095-4dannjjm 1480 7 fevers fever NNS cord-023095-4dannjjm 1480 8 typical typical JJ cord-023095-4dannjjm 1480 9 for for IN cord-023095-4dannjjm 1480 10 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1480 11 infections infection NNS cord-023095-4dannjjm 1480 12 . . . cord-023095-4dannjjm 1481 1 One one CD cord-023095-4dannjjm 1481 2 horse horse NN cord-023095-4dannjjm 1481 3 developed develop VBD cord-023095-4dannjjm 1481 4 acute acute JJ cord-023095-4dannjjm 1481 5 EHM ehm UH cord-023095-4dannjjm 1481 6 on on IN cord-023095-4dannjjm 1481 7 D10 D10 NNP cord-023095-4dannjjm 1481 8 and and CC cord-023095-4dannjjm 1481 9 was be VBD cord-023095-4dannjjm 1481 10 euthanized euthanize VBN cord-023095-4dannjjm 1481 11 after after IN cord-023095-4dannjjm 1481 12 samples sample NNS cord-023095-4dannjjm 1481 13 were be VBD cord-023095-4dannjjm 1481 14 collected collect VBN cord-023095-4dannjjm 1481 15 . . . cord-023095-4dannjjm 1482 1 In in IN cord-023095-4dannjjm 1482 2 all all DT cord-023095-4dannjjm 1482 3 horses horse NNS cord-023095-4dannjjm 1482 4 D D NNS cord-023095-4dannjjm 1482 5 - - HYPH cord-023095-4dannjjm 1482 6 dimers dimer NNS cord-023095-4dannjjm 1482 7 were be VBD cord-023095-4dannjjm 1482 8 undetectable undetectable JJ cord-023095-4dannjjm 1482 9 on on IN cord-023095-4dannjjm 1482 10 D D NNP cord-023095-4dannjjm 1482 11 -1 -1 NN cord-023095-4dannjjm 1482 12 and and CC cord-023095-4dannjjm 1482 13 on on IN cord-023095-4dannjjm 1482 14 D4 d4 NN cord-023095-4dannjjm 1482 15 , , , cord-023095-4dannjjm 1482 16 5 5 CD cord-023095-4dannjjm 1482 17 and and CC cord-023095-4dannjjm 1482 18 11 11 CD cord-023095-4dannjjm 1482 19 . . . cord-023095-4dannjjm 1483 1 In in IN cord-023095-4dannjjm 1483 2 contrast contrast NN cord-023095-4dannjjm 1483 3 , , , cord-023095-4dannjjm 1483 4 all all DT cord-023095-4dannjjm 1483 5 horses horse NNS cord-023095-4dannjjm 1483 6 had have VBD cord-023095-4dannjjm 1483 7 increased increase VBN cord-023095-4dannjjm 1483 8 Ddimer Ddimer NNP cord-023095-4dannjjm 1483 9 concentrations concentration NNS cord-023095-4dannjjm 1483 10 for for IN cord-023095-4dannjjm 1483 11 3 3 CD cord-023095-4dannjjm 1483 12 to to TO cord-023095-4dannjjm 1483 13 5 5 CD cord-023095-4dannjjm 1483 14 consecutive consecutive JJ cord-023095-4dannjjm 1483 15 days day NNS cord-023095-4dannjjm 1483 16 starting start VBG cord-023095-4dannjjm 1483 17 on on IN cord-023095-4dannjjm 1483 18 day day NN cord-023095-4dannjjm 1483 19 6 6 CD cord-023095-4dannjjm 1483 20 post post NN cord-023095-4dannjjm 1483 21 - - NN cord-023095-4dannjjm 1483 22 infection infection NN cord-023095-4dannjjm 1483 23 . . . cord-023095-4dannjjm 1484 1 D d NN cord-023095-4dannjjm 1484 2 - - HYPH cord-023095-4dannjjm 1484 3 dimer dimer JJ cord-023095-4dannjjm 1484 4 concentrations concentration NNS cord-023095-4dannjjm 1484 5 in in IN cord-023095-4dannjjm 1484 6 2 2 CD cord-023095-4dannjjm 1484 7 horses horse NNS cord-023095-4dannjjm 1484 8 increased increase VBD cord-023095-4dannjjm 1484 9 to to IN cord-023095-4dannjjm 1484 10 1000 1000 CD cord-023095-4dannjjm 1484 11 ug ug NNP cord-023095-4dannjjm 1484 12 / / SYM cord-023095-4dannjjm 1484 13 ml ml NN cord-023095-4dannjjm 1484 14 and and CC cord-023095-4dannjjm 1484 15 one one CD cord-023095-4dannjjm 1484 16 of of IN cord-023095-4dannjjm 1484 17 these these DT cord-023095-4dannjjm 1484 18 horses horse NNS cord-023095-4dannjjm 1484 19 was be VBD cord-023095-4dannjjm 1484 20 the the DT cord-023095-4dannjjm 1484 21 horse horse NN cord-023095-4dannjjm 1484 22 with with IN cord-023095-4dannjjm 1484 23 acute acute JJ cord-023095-4dannjjm 1484 24 EHM EHM NNP cord-023095-4dannjjm 1484 25 . . . cord-023095-4dannjjm 1485 1 Interestingly interestingly RB cord-023095-4dannjjm 1485 2 , , , cord-023095-4dannjjm 1485 3 mean mean JJ cord-023095-4dannjjm 1485 4 increased increase VBN cord-023095-4dannjjm 1485 5 D d NN cord-023095-4dannjjm 1485 6 - - HYPH cord-023095-4dannjjm 1485 7 dimer dimer NN cord-023095-4dannjjm 1485 8 concentrations concentration NNS cord-023095-4dannjjm 1485 9 showed show VBD cord-023095-4dannjjm 1485 10 timely timely RB cord-023095-4dannjjm 1485 11 overlap overlap VBP cord-023095-4dannjjm 1485 12 with with IN cord-023095-4dannjjm 1485 13 the the DT cord-023095-4dannjjm 1485 14 mean mean JJ cord-023095-4dannjjm 1485 15 fever fever NN cord-023095-4dannjjm 1485 16 curve curve NN cord-023095-4dannjjm 1485 17 and and CC cord-023095-4dannjjm 1485 18 , , , cord-023095-4dannjjm 1485 19 delayed delay VBN cord-023095-4dannjjm 1485 20 by by IN cord-023095-4dannjjm 1485 21 1 1 CD cord-023095-4dannjjm 1485 22 day day NN cord-023095-4dannjjm 1485 23 , , , cord-023095-4dannjjm 1485 24 with with IN cord-023095-4dannjjm 1485 25 the the DT cord-023095-4dannjjm 1485 26 mean mean JJ cord-023095-4dannjjm 1485 27 viremia viremia NN cord-023095-4dannjjm 1485 28 curve curve NN cord-023095-4dannjjm 1485 29 . . . cord-023095-4dannjjm 1486 1 Because because IN cord-023095-4dannjjm 1486 2 plasma plasma NN cord-023095-4dannjjm 1486 3 samples sample NNS cord-023095-4dannjjm 1486 4 for for IN cord-023095-4dannjjm 1486 5 D d NN cord-023095-4dannjjm 1486 6 - - HYPH cord-023095-4dannjjm 1486 7 dimer dimer NN cord-023095-4dannjjm 1486 8 measurements measurement NNS cord-023095-4dannjjm 1486 9 were be VBD cord-023095-4dannjjm 1486 10 not not RB cord-023095-4dannjjm 1486 11 collected collect VBN cord-023095-4dannjjm 1486 12 during during IN cord-023095-4dannjjm 1486 13 the the DT cord-023095-4dannjjm 1486 14 first first JJ cord-023095-4dannjjm 1486 15 3 3 CD cord-023095-4dannjjm 1486 16 days day NNS cord-023095-4dannjjm 1486 17 post post NN cord-023095-4dannjjm 1486 18 - - NN cord-023095-4dannjjm 1486 19 infection infection NN cord-023095-4dannjjm 1486 20 , , , cord-023095-4dannjjm 1486 21 which which WDT cord-023095-4dannjjm 1486 22 are be VBP cord-023095-4dannjjm 1486 23 typically typically RB cord-023095-4dannjjm 1486 24 associated associate VBN cord-023095-4dannjjm 1486 25 with with IN cord-023095-4dannjjm 1486 26 a a DT cord-023095-4dannjjm 1486 27 primary primary JJ cord-023095-4dannjjm 1486 28 fever fever NN cord-023095-4dannjjm 1486 29 , , , cord-023095-4dannjjm 1486 30 conclusion conclusion NN cord-023095-4dannjjm 1486 31 on on IN cord-023095-4dannjjm 1486 32 the the DT cord-023095-4dannjjm 1486 33 association association NN cord-023095-4dannjjm 1486 34 of of IN cord-023095-4dannjjm 1486 35 D D NNP cord-023095-4dannjjm 1486 36 - - HYPH cord-023095-4dannjjm 1486 37 Dimers Dimers NNPS cord-023095-4dannjjm 1486 38 with with IN cord-023095-4dannjjm 1486 39 fever fever NN cord-023095-4dannjjm 1486 40 of of IN cord-023095-4dannjjm 1486 41 viremia viremia NN cord-023095-4dannjjm 1486 42 await await VBP cord-023095-4dannjjm 1486 43 analysis analysis NN cord-023095-4dannjjm 1486 44 of of IN cord-023095-4dannjjm 1486 45 a a DT cord-023095-4dannjjm 1486 46 second second JJ cord-023095-4dannjjm 1486 47 study study NN cord-023095-4dannjjm 1486 48 currently currently RB cord-023095-4dannjjm 1486 49 conducted conduct VBN cord-023095-4dannjjm 1486 50 in in IN cord-023095-4dannjjm 1486 51 our -PRON- PRP$ cord-023095-4dannjjm 1486 52 laboratory laboratory NN cord-023095-4dannjjm 1486 53 . . . cord-023095-4dannjjm 1487 1 In in IN cord-023095-4dannjjm 1487 2 conclusion conclusion NN cord-023095-4dannjjm 1487 3 our -PRON- PRP$ cord-023095-4dannjjm 1487 4 data data NN cord-023095-4dannjjm 1487 5 indicates indicate VBZ cord-023095-4dannjjm 1487 6 that that IN cord-023095-4dannjjm 1487 7 during during IN cord-023095-4dannjjm 1487 8 EHV-1 EHV-1 NNP cord-023095-4dannjjm 1487 9 infection infection NN cord-023095-4dannjjm 1487 10 with with IN cord-023095-4dannjjm 1487 11 neuropathogenic neuropathogenic NNP cord-023095-4dannjjm 1487 12 strains strain NNS cord-023095-4dannjjm 1487 13 activation activation NN cord-023095-4dannjjm 1487 14 of of IN cord-023095-4dannjjm 1487 15 the the DT cord-023095-4dannjjm 1487 16 coagulation coagulation NN cord-023095-4dannjjm 1487 17 cascade cascade NN cord-023095-4dannjjm 1487 18 and and CC cord-023095-4dannjjm 1487 19 production production NN cord-023095-4dannjjm 1487 20 of of IN cord-023095-4dannjjm 1487 21 cross cross NN cord-023095-4dannjjm 1487 22 - - JJ cord-023095-4dannjjm 1487 23 linked link VBN cord-023095-4dannjjm 1487 24 fibrin fibrin NN cord-023095-4dannjjm 1487 25 is be VBZ cord-023095-4dannjjm 1487 26 wide wide JJ cord-023095-4dannjjm 1487 27 - - HYPH cord-023095-4dannjjm 1487 28 spread spread NN cord-023095-4dannjjm 1487 29 ; ; : cord-023095-4dannjjm 1487 30 not not RB cord-023095-4dannjjm 1487 31 limited limit VBN cord-023095-4dannjjm 1487 32 to to IN cord-023095-4dannjjm 1487 33 horses horse NNS cord-023095-4dannjjm 1487 34 with with IN cord-023095-4dannjjm 1487 35 clinical clinical JJ cord-023095-4dannjjm 1487 36 signs sign NNS cord-023095-4dannjjm 1487 37 of of IN cord-023095-4dannjjm 1487 38 EHM EHM NNP cord-023095-4dannjjm 1487 39 , , , cord-023095-4dannjjm 1487 40 and and CC cord-023095-4dannjjm 1487 41 can can MD cord-023095-4dannjjm 1487 42 be be VB cord-023095-4dannjjm 1487 43 expected expect VBN cord-023095-4dannjjm 1487 44 between between IN cord-023095-4dannjjm 1487 45 days day NNS cord-023095-4dannjjm 1487 46 6 6 CD cord-023095-4dannjjm 1487 47 and and CC cord-023095-4dannjjm 1487 48 10 10 CD cord-023095-4dannjjm 1487 49 post post NN cord-023095-4dannjjm 1487 50 - - NN cord-023095-4dannjjm 1487 51 infection infection NN cord-023095-4dannjjm 1487 52 . . . cord-023095-4dannjjm 1488 1 Lawsonia Lawsonia NNP cord-023095-4dannjjm 1488 2 intracellularis intracellularis NN cord-023095-4dannjjm 1488 3 is be VBZ cord-023095-4dannjjm 1488 4 an an DT cord-023095-4dannjjm 1488 5 emerging emerge VBG cord-023095-4dannjjm 1488 6 pathogen pathogen NN cord-023095-4dannjjm 1488 7 in in IN cord-023095-4dannjjm 1488 8 horses horse NNS cord-023095-4dannjjm 1488 9 and and CC cord-023095-4dannjjm 1488 10 the the DT cord-023095-4dannjjm 1488 11 causative causative JJ cord-023095-4dannjjm 1488 12 agent agent NN cord-023095-4dannjjm 1488 13 in in IN cord-023095-4dannjjm 1488 14 Equine Equine NNP cord-023095-4dannjjm 1488 15 Proliferative Proliferative NNP cord-023095-4dannjjm 1488 16 Enteropathy Enteropathy NNP cord-023095-4dannjjm 1488 17 ( ( -LRB- cord-023095-4dannjjm 1488 18 EPE EPE NNP cord-023095-4dannjjm 1488 19 ) ) -RRB- cord-023095-4dannjjm 1488 20 . . . cord-023095-4dannjjm 1489 1 The the DT cord-023095-4dannjjm 1489 2 goal goal NN cord-023095-4dannjjm 1489 3 of of IN cord-023095-4dannjjm 1489 4 this this DT cord-023095-4dannjjm 1489 5 study study NN cord-023095-4dannjjm 1489 6 was be VBD cord-023095-4dannjjm 1489 7 to to TO cord-023095-4dannjjm 1489 8 evaluate evaluate VB cord-023095-4dannjjm 1489 9 the the DT cord-023095-4dannjjm 1489 10 exposure exposure NN cord-023095-4dannjjm 1489 11 of of IN cord-023095-4dannjjm 1489 12 pre pre JJ cord-023095-4dannjjm 1489 13 - - JJ cord-023095-4dannjjm 1489 14 weanling weanling JJ cord-023095-4dannjjm 1489 15 foals foal NNS cord-023095-4dannjjm 1489 16 and and CC cord-023095-4dannjjm 1489 17 broodmares broodmare NNS cord-023095-4dannjjm 1489 18 to to IN cord-023095-4dannjjm 1489 19 Lawsonia Lawsonia NNP cord-023095-4dannjjm 1489 20 intracelluaris intracelluaris RB cord-023095-4dannjjm 1489 21 on on IN cord-023095-4dannjjm 1489 22 several several JJ cord-023095-4dannjjm 1489 23 farms farm NNS cord-023095-4dannjjm 1489 24 in in IN cord-023095-4dannjjm 1489 25 Louisiana Louisiana NNP cord-023095-4dannjjm 1489 26 with with IN cord-023095-4dannjjm 1489 27 a a DT cord-023095-4dannjjm 1489 28 history history NN cord-023095-4dannjjm 1489 29 of of IN cord-023095-4dannjjm 1489 30 EPE EPE NNP cord-023095-4dannjjm 1489 31 and and CC cord-023095-4dannjjm 1489 32 compare compare VB cord-023095-4dannjjm 1489 33 the the DT cord-023095-4dannjjm 1489 34 results result NNS cord-023095-4dannjjm 1489 35 to to IN cord-023095-4dannjjm 1489 36 several several JJ cord-023095-4dannjjm 1489 37 farms farm NNS cord-023095-4dannjjm 1489 38 with with IN cord-023095-4dannjjm 1489 39 no no DT cord-023095-4dannjjm 1489 40 known know VBN cord-023095-4dannjjm 1489 41 clinical clinical JJ cord-023095-4dannjjm 1489 42 cases case NNS cord-023095-4dannjjm 1489 43 of of IN cord-023095-4dannjjm 1489 44 EPE EPE NNP cord-023095-4dannjjm 1489 45 in in IN cord-023095-4dannjjm 1489 46 foals foal NNS cord-023095-4dannjjm 1489 47 . . . cord-023095-4dannjjm 1490 1 An an DT cord-023095-4dannjjm 1490 2 additional additional JJ cord-023095-4dannjjm 1490 3 goal goal NN cord-023095-4dannjjm 1490 4 of of IN cord-023095-4dannjjm 1490 5 the the DT cord-023095-4dannjjm 1490 6 study study NN cord-023095-4dannjjm 1490 7 was be VBD cord-023095-4dannjjm 1490 8 to to TO cord-023095-4dannjjm 1490 9 identify identify VB cord-023095-4dannjjm 1490 10 whether whether IN cord-023095-4dannjjm 1490 11 a a DT cord-023095-4dannjjm 1490 12 relationship relationship NN cord-023095-4dannjjm 1490 13 exists exist VBZ cord-023095-4dannjjm 1490 14 between between IN cord-023095-4dannjjm 1490 15 Lawsonia Lawsonia NNP cord-023095-4dannjjm 1490 16 intracelluaris intracelluaris JJ cord-023095-4dannjjm 1490 17 and and CC cord-023095-4dannjjm 1490 18 other other JJ cord-023095-4dannjjm 1490 19 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1490 20 pathogens pathogen NNS cord-023095-4dannjjm 1490 21 in in IN cord-023095-4dannjjm 1490 22 foals foal NNS cord-023095-4dannjjm 1490 23 . . . cord-023095-4dannjjm 1491 1 Whole whole JJ cord-023095-4dannjjm 1491 2 blood blood NN cord-023095-4dannjjm 1491 3 and and CC cord-023095-4dannjjm 1491 4 fecal fecal JJ cord-023095-4dannjjm 1491 5 samples sample NNS cord-023095-4dannjjm 1491 6 were be VBD cord-023095-4dannjjm 1491 7 collected collect VBN cord-023095-4dannjjm 1491 8 from from IN cord-023095-4dannjjm 1491 9 66 66 CD cord-023095-4dannjjm 1491 10 mares mare NNS cord-023095-4dannjjm 1491 11 and and CC cord-023095-4dannjjm 1491 12 68 68 CD cord-023095-4dannjjm 1491 13 foals foal NNS cord-023095-4dannjjm 1491 14 from from IN cord-023095-4dannjjm 1491 15 four four CD cord-023095-4dannjjm 1491 16 breeding breed VBG cord-023095-4dannjjm 1491 17 farms farm NNS cord-023095-4dannjjm 1491 18 in in IN cord-023095-4dannjjm 1491 19 Louisiana Louisiana NNP cord-023095-4dannjjm 1491 20 . . . cord-023095-4dannjjm 1492 1 Farms farm NNS cord-023095-4dannjjm 1492 2 A A NNP cord-023095-4dannjjm 1492 3 and and CC cord-023095-4dannjjm 1492 4 B B NNP cord-023095-4dannjjm 1492 5 had have VBD cord-023095-4dannjjm 1492 6 no no DT cord-023095-4dannjjm 1492 7 known know VBN cord-023095-4dannjjm 1492 8 clinical clinical JJ cord-023095-4dannjjm 1492 9 cases case NNS cord-023095-4dannjjm 1492 10 of of IN cord-023095-4dannjjm 1492 11 EPE EPE NNP cord-023095-4dannjjm 1492 12 , , , cord-023095-4dannjjm 1492 13 while while IN cord-023095-4dannjjm 1492 14 Farms farm NNS cord-023095-4dannjjm 1492 15 C C NNP cord-023095-4dannjjm 1492 16 and and CC cord-023095-4dannjjm 1492 17 D D NNP cord-023095-4dannjjm 1492 18 had have VBD cord-023095-4dannjjm 1492 19 previous previous JJ cord-023095-4dannjjm 1492 20 know know NN cord-023095-4dannjjm 1492 21 cases case NNS cord-023095-4dannjjm 1492 22 of of IN cord-023095-4dannjjm 1492 23 EPE EPE NNP cord-023095-4dannjjm 1492 24 in in IN cord-023095-4dannjjm 1492 25 2009 2009 CD cord-023095-4dannjjm 1492 26 . . . cord-023095-4dannjjm 1493 1 Serum serum NN cord-023095-4dannjjm 1493 2 samples sample NNS cord-023095-4dannjjm 1493 3 were be VBD cord-023095-4dannjjm 1493 4 examined examine VBN cord-023095-4dannjjm 1493 5 for for IN cord-023095-4dannjjm 1493 6 the the DT cord-023095-4dannjjm 1493 7 presence presence NN cord-023095-4dannjjm 1493 8 of of IN cord-023095-4dannjjm 1493 9 antibodies antibody NNS cord-023095-4dannjjm 1493 10 against against IN cord-023095-4dannjjm 1493 11 Lawsonia Lawsonia NNP cord-023095-4dannjjm 1493 12 intracellularis intracellularis NNP cord-023095-4dannjjm 1493 13 using use VBG cord-023095-4dannjjm 1493 14 an an DT cord-023095-4dannjjm 1493 15 immunoperoxidase immunoperoxidase NN cord-023095-4dannjjm 1493 16 monolayer monolayer NN cord-023095-4dannjjm 1493 17 assay assay NN cord-023095-4dannjjm 1493 18 ( ( -LRB- cord-023095-4dannjjm 1493 19 IPMA IPMA NNP cord-023095-4dannjjm 1493 20 ) ) -RRB- cord-023095-4dannjjm 1493 21 . . . cord-023095-4dannjjm 1494 1 DNA DNA NNP cord-023095-4dannjjm 1494 2 was be VBD cord-023095-4dannjjm 1494 3 extracted extract VBN cord-023095-4dannjjm 1494 4 from from IN cord-023095-4dannjjm 1494 5 fecal fecal JJ cord-023095-4dannjjm 1494 6 samples sample NNS cord-023095-4dannjjm 1494 7 using use VBG cord-023095-4dannjjm 1494 8 a a DT cord-023095-4dannjjm 1494 9 commercial commercial JJ cord-023095-4dannjjm 1494 10 DNA dna NN cord-023095-4dannjjm 1494 11 kit kit NN cord-023095-4dannjjm 1494 12 and and CC cord-023095-4dannjjm 1494 13 molecular molecular JJ cord-023095-4dannjjm 1494 14 detection detection NN cord-023095-4dannjjm 1494 15 of of IN cord-023095-4dannjjm 1494 16 Lawsonia Lawsonia NNP cord-023095-4dannjjm 1494 17 intracelluaris intracelluaris NNP cord-023095-4dannjjm 1494 18 was be VBD cord-023095-4dannjjm 1494 19 assayed assay VBN cord-023095-4dannjjm 1494 20 using use VBG cord-023095-4dannjjm 1494 21 real real JJ cord-023095-4dannjjm 1494 22 - - HYPH cord-023095-4dannjjm 1494 23 time time NN cord-023095-4dannjjm 1494 24 PCR PCR NNP cord-023095-4dannjjm 1494 25 . . . cord-023095-4dannjjm 1495 1 Fecal fecal JJ cord-023095-4dannjjm 1495 2 ova ova NN cord-023095-4dannjjm 1495 3 were be VBD cord-023095-4dannjjm 1495 4 determined determine VBN cord-023095-4dannjjm 1495 5 using use VBG cord-023095-4dannjjm 1495 6 quantitative quantitative JJ cord-023095-4dannjjm 1495 7 sucrose sucrose NN cord-023095-4dannjjm 1495 8 floatation floatation NN cord-023095-4dannjjm 1495 9 . . . cord-023095-4dannjjm 1496 1 The the DT cord-023095-4dannjjm 1496 2 presence presence NN cord-023095-4dannjjm 1496 3 of of IN cord-023095-4dannjjm 1496 4 fecal fecal JJ cord-023095-4dannjjm 1496 5 Clostridium clostridium NN cord-023095-4dannjjm 1496 6 difficile difficile NN cord-023095-4dannjjm 1496 7 toxin toxin NN cord-023095-4dannjjm 1496 8 was be VBD cord-023095-4dannjjm 1496 9 measured measure VBN cord-023095-4dannjjm 1496 10 using use VBG cord-023095-4dannjjm 1496 11 a a DT cord-023095-4dannjjm 1496 12 commercial commercial JJ cord-023095-4dannjjm 1496 13 enzyme enzyme NN cord-023095-4dannjjm 1496 14 linked link VBN cord-023095-4dannjjm 1496 15 immunosorbent immunosorbent JJ cord-023095-4dannjjm 1496 16 assay assay NN cord-023095-4dannjjm 1496 17 ( ( -LRB- cord-023095-4dannjjm 1496 18 ELISA ELISA NNP cord-023095-4dannjjm 1496 19 ) ) -RRB- cord-023095-4dannjjm 1496 20 . . . cord-023095-4dannjjm 1497 1 Three three CD cord-023095-4dannjjm 1497 2 of of IN cord-023095-4dannjjm 1497 3 the the DT cord-023095-4dannjjm 1497 4 4 4 CD cord-023095-4dannjjm 1497 5 farms farm NNS cord-023095-4dannjjm 1497 6 examined examine VBN cord-023095-4dannjjm 1497 7 had have VBD cord-023095-4dannjjm 1497 8 foals foal NNS cord-023095-4dannjjm 1497 9 and and CC cord-023095-4dannjjm 1497 10 mares mare NNS cord-023095-4dannjjm 1497 11 with with IN cord-023095-4dannjjm 1497 12 exposure exposure NN cord-023095-4dannjjm 1497 13 to to IN cord-023095-4dannjjm 1497 14 L. L. NNP cord-023095-4dannjjm 1497 15 intracellularis intracellularis NNP cord-023095-4dannjjm 1497 16 as as IN cord-023095-4dannjjm 1497 17 evidenced evidence VBN cord-023095-4dannjjm 1497 18 by by IN cord-023095-4dannjjm 1497 19 serum serum NN cord-023095-4dannjjm 1497 20 antibodies antibody NNS cord-023095-4dannjjm 1497 21 against against IN cord-023095-4dannjjm 1497 22 the the DT cord-023095-4dannjjm 1497 23 organism organism NN cord-023095-4dannjjm 1497 24 . . . cord-023095-4dannjjm 1498 1 Of of IN cord-023095-4dannjjm 1498 2 the the DT cord-023095-4dannjjm 1498 3 total total JJ cord-023095-4dannjjm 1498 4 population population NN cord-023095-4dannjjm 1498 5 sampled sample VBN cord-023095-4dannjjm 1498 6 , , , cord-023095-4dannjjm 1498 7 6 6 CD cord-023095-4dannjjm 1498 8 foals foal NNS cord-023095-4dannjjm 1498 9 ( ( -LRB- cord-023095-4dannjjm 1498 10 8.8 8.8 CD cord-023095-4dannjjm 1498 11 % % NN cord-023095-4dannjjm 1498 12 ) ) -RRB- cord-023095-4dannjjm 1498 13 and and CC cord-023095-4dannjjm 1498 14 14 14 CD cord-023095-4dannjjm 1498 15 mares mare NNS cord-023095-4dannjjm 1498 16 ( ( -LRB- cord-023095-4dannjjm 1498 17 21.2 21.2 CD cord-023095-4dannjjm 1498 18 % % NN cord-023095-4dannjjm 1498 19 ) ) -RRB- cord-023095-4dannjjm 1498 20 had have VBD cord-023095-4dannjjm 1498 21 evidence evidence NN cord-023095-4dannjjm 1498 22 of of IN cord-023095-4dannjjm 1498 23 antibodies antibody NNS cord-023095-4dannjjm 1498 24 to to IN cord-023095-4dannjjm 1498 25 L. L. NNP cord-023095-4dannjjm 1498 26 intracellularis intracellularis NNP cord-023095-4dannjjm 1498 27 based base VBN cord-023095-4dannjjm 1498 28 on on IN cord-023095-4dannjjm 1498 29 serology serology NN cord-023095-4dannjjm 1498 30 . . . cord-023095-4dannjjm 1499 1 Three three CD cord-023095-4dannjjm 1499 2 foals foal NNS cord-023095-4dannjjm 1499 3 ( ( -LRB- cord-023095-4dannjjm 1499 4 4.4 4.4 CD cord-023095-4dannjjm 1499 5 % % NN cord-023095-4dannjjm 1499 6 ) ) -RRB- cord-023095-4dannjjm 1499 7 tested test VBD cord-023095-4dannjjm 1499 8 positive positive JJ cord-023095-4dannjjm 1499 9 for for IN cord-023095-4dannjjm 1499 10 L. L. NNP cord-023095-4dannjjm 1499 11 intracellularis intracellularis JJ cord-023095-4dannjjm 1499 12 organism organism NN cord-023095-4dannjjm 1499 13 by by IN cord-023095-4dannjjm 1499 14 fecal fecal JJ cord-023095-4dannjjm 1499 15 PCR PCR NNP cord-023095-4dannjjm 1499 16 , , , cord-023095-4dannjjm 1499 17 and and CC cord-023095-4dannjjm 1499 18 all all DT cord-023095-4dannjjm 1499 19 of of IN cord-023095-4dannjjm 1499 20 these these DT cord-023095-4dannjjm 1499 21 foals foal NNS cord-023095-4dannjjm 1499 22 were be VBD cord-023095-4dannjjm 1499 23 located locate VBN cord-023095-4dannjjm 1499 24 on on IN cord-023095-4dannjjm 1499 25 farm farm NN cord-023095-4dannjjm 1499 26 C. C. NNP cord-023095-4dannjjm 1499 27 Of of IN cord-023095-4dannjjm 1499 28 these these DT cord-023095-4dannjjm 1499 29 , , , cord-023095-4dannjjm 1499 30 one one CD cord-023095-4dannjjm 1499 31 of of IN cord-023095-4dannjjm 1499 32 the the DT cord-023095-4dannjjm 1499 33 foals foal NNS cord-023095-4dannjjm 1499 34 was be VBD cord-023095-4dannjjm 1499 35 seronegative seronegative JJ cord-023095-4dannjjm 1499 36 , , , cord-023095-4dannjjm 1499 37 while while IN cord-023095-4dannjjm 1499 38 the the DT cord-023095-4dannjjm 1499 39 other other JJ cord-023095-4dannjjm 1499 40 two two CD cord-023095-4dannjjm 1499 41 were be VBD cord-023095-4dannjjm 1499 42 seropositive seropositive JJ cord-023095-4dannjjm 1499 43 . . . cord-023095-4dannjjm 1500 1 Farm farm NN cord-023095-4dannjjm 1500 2 C C NNP cord-023095-4dannjjm 1500 3 also also RB cord-023095-4dannjjm 1500 4 had have VBD cord-023095-4dannjjm 1500 5 the the DT cord-023095-4dannjjm 1500 6 highest high JJS cord-023095-4dannjjm 1500 7 percentage percentage NN cord-023095-4dannjjm 1500 8 of of IN cord-023095-4dannjjm 1500 9 mares mare NNS cord-023095-4dannjjm 1500 10 ( ( -LRB- cord-023095-4dannjjm 1500 11 28.6 28.6 CD cord-023095-4dannjjm 1500 12 % % NN cord-023095-4dannjjm 1500 13 ) ) -RRB- cord-023095-4dannjjm 1500 14 serologically serologically RB cord-023095-4dannjjm 1500 15 positive positive JJ cord-023095-4dannjjm 1500 16 for for IN cord-023095-4dannjjm 1500 17 L. L. NNP cord-023095-4dannjjm 1500 18 intracellularis intracellularis NNP cord-023095-4dannjjm 1500 19 , , , cord-023095-4dannjjm 1500 20 while while IN cord-023095-4dannjjm 1500 21 Farm Farm NNP cord-023095-4dannjjm 1500 22 A A NNP cord-023095-4dannjjm 1500 23 had have VBD cord-023095-4dannjjm 1500 24 the the DT cord-023095-4dannjjm 1500 25 highest high JJS cord-023095-4dannjjm 1500 26 percentage percentage NN cord-023095-4dannjjm 1500 27 of of IN cord-023095-4dannjjm 1500 28 foals foal NNS cord-023095-4dannjjm 1500 29 ( ( -LRB- cord-023095-4dannjjm 1500 30 14.3 14.3 CD cord-023095-4dannjjm 1500 31 % % NN cord-023095-4dannjjm 1500 32 ) ) -RRB- cord-023095-4dannjjm 1500 33 with with IN cord-023095-4dannjjm 1500 34 antibody antibody NN cord-023095-4dannjjm 1500 35 titers titer NNS cord-023095-4dannjjm 1500 36 against against IN cord-023095-4dannjjm 1500 37 L L NNP cord-023095-4dannjjm 1500 38 intracellaris intracellaris NNP cord-023095-4dannjjm 1500 39 . . . cord-023095-4dannjjm 1501 1 Farm farm NN cord-023095-4dannjjm 1501 2 C C NNP cord-023095-4dannjjm 1501 3 also also RB cord-023095-4dannjjm 1501 4 had have VBD cord-023095-4dannjjm 1501 5 the the DT cord-023095-4dannjjm 1501 6 only only JJ cord-023095-4dannjjm 1501 7 pairs pair NNS cord-023095-4dannjjm 1501 8 ( ( -LRB- cord-023095-4dannjjm 1501 9 n n NN cord-023095-4dannjjm 1501 10 5 5 CD cord-023095-4dannjjm 1501 11 3 3 CD cord-023095-4dannjjm 1501 12 ) ) -RRB- cord-023095-4dannjjm 1501 13 of of IN cord-023095-4dannjjm 1501 14 serologically serologically RB cord-023095-4dannjjm 1501 15 positive positive JJ cord-023095-4dannjjm 1501 16 mares mare NNS cord-023095-4dannjjm 1501 17 with with IN cord-023095-4dannjjm 1501 18 seropositive seropositive JJ cord-023095-4dannjjm 1501 19 foals foal NNS cord-023095-4dannjjm 1501 20 . . . cord-023095-4dannjjm 1502 1 While while IN cord-023095-4dannjjm 1502 2 Farm Farm NNP cord-023095-4dannjjm 1502 3 A A NNP cord-023095-4dannjjm 1502 4 and and CC cord-023095-4dannjjm 1502 5 B B NNP cord-023095-4dannjjm 1502 6 had have VBD cord-023095-4dannjjm 1502 7 seropositive seropositive JJ cord-023095-4dannjjm 1502 8 mares mare NNS cord-023095-4dannjjm 1502 9 and/or and/or CC cord-023095-4dannjjm 1502 10 foals foal NNS cord-023095-4dannjjm 1502 11 , , , cord-023095-4dannjjm 1502 12 none none NN cord-023095-4dannjjm 1502 13 of of IN cord-023095-4dannjjm 1502 14 the the DT cord-023095-4dannjjm 1502 15 foals foal NNS cord-023095-4dannjjm 1502 16 were be VBD cord-023095-4dannjjm 1502 17 positive positive JJ cord-023095-4dannjjm 1502 18 for for IN cord-023095-4dannjjm 1502 19 L. L. NNP cord-023095-4dannjjm 1502 20 intracellularis intracellularis JJ cord-023095-4dannjjm 1502 21 fecal fecal JJ cord-023095-4dannjjm 1502 22 shedding shed VBG cord-023095-4dannjjm 1502 23 by by IN cord-023095-4dannjjm 1502 24 PCR PCR NNP cord-023095-4dannjjm 1502 25 . . . cord-023095-4dannjjm 1503 1 All all DT cord-023095-4dannjjm 1503 2 serum serum NN cord-023095-4dannjjm 1503 3 and and CC cord-023095-4dannjjm 1503 4 fecal fecal JJ cord-023095-4dannjjm 1503 5 samples sample NNS cord-023095-4dannjjm 1503 6 were be VBD cord-023095-4dannjjm 1503 7 negative negative JJ cord-023095-4dannjjm 1503 8 for for IN cord-023095-4dannjjm 1503 9 evidence evidence NN cord-023095-4dannjjm 1503 10 of of IN cord-023095-4dannjjm 1503 11 L. L. NNP cord-023095-4dannjjm 1503 12 intracellaris intracellaris NNP cord-023095-4dannjjm 1503 13 on on IN cord-023095-4dannjjm 1503 14 Farm Farm NNP cord-023095-4dannjjm 1503 15 D. D. NNP cord-023095-4dannjjm 1503 16 Ten ten CD cord-023095-4dannjjm 1503 17 foals foal NNS cord-023095-4dannjjm 1503 18 ( ( -LRB- cord-023095-4dannjjm 1503 19 14 14 CD cord-023095-4dannjjm 1503 20 % % NN cord-023095-4dannjjm 1503 21 ) ) -RRB- cord-023095-4dannjjm 1503 22 had have VBD cord-023095-4dannjjm 1503 23 fecal fecal JJ cord-023095-4dannjjm 1503 24 egg egg NN cord-023095-4dannjjm 1503 25 counts count NNS cord-023095-4dannjjm 1504 1 greater great JJR cord-023095-4dannjjm 1504 2 than than IN cord-023095-4dannjjm 1504 3 200 200 CD cord-023095-4dannjjm 1504 4 egg egg NN cord-023095-4dannjjm 1504 5 per per IN cord-023095-4dannjjm 1504 6 gram gram NN cord-023095-4dannjjm 1504 7 and and CC cord-023095-4dannjjm 1504 8 2 2 CD cord-023095-4dannjjm 1504 9 foals foal NNS cord-023095-4dannjjm 1504 10 ( ( -LRB- cord-023095-4dannjjm 1504 11 3 3 CD cord-023095-4dannjjm 1504 12 % % NN cord-023095-4dannjjm 1504 13 ) ) -RRB- cord-023095-4dannjjm 1504 14 were be VBD cord-023095-4dannjjm 1504 15 positive positive JJ cord-023095-4dannjjm 1504 16 for for IN cord-023095-4dannjjm 1504 17 C. C. NNP cord-023095-4dannjjm 1504 18 difficile difficile NN cord-023095-4dannjjm 1504 19 toxin toxin NN cord-023095-4dannjjm 1504 20 . . . cord-023095-4dannjjm 1505 1 This this DT cord-023095-4dannjjm 1505 2 study study NN cord-023095-4dannjjm 1505 3 demonstrated demonstrate VBD cord-023095-4dannjjm 1505 4 evidence evidence NN cord-023095-4dannjjm 1505 5 of of IN cord-023095-4dannjjm 1505 6 natural natural JJ cord-023095-4dannjjm 1505 7 exposure exposure NN cord-023095-4dannjjm 1505 8 to to IN cord-023095-4dannjjm 1505 9 L L NNP cord-023095-4dannjjm 1505 10 intracellularis intracellularis NNP cord-023095-4dannjjm 1505 11 on on IN cord-023095-4dannjjm 1505 12 farms farm NNS cord-023095-4dannjjm 1505 13 both both CC cord-023095-4dannjjm 1505 14 with with IN cord-023095-4dannjjm 1505 15 and and CC cord-023095-4dannjjm 1505 16 without without IN cord-023095-4dannjjm 1505 17 a a DT cord-023095-4dannjjm 1505 18 history history NN cord-023095-4dannjjm 1505 19 of of IN cord-023095-4dannjjm 1505 20 EPE EPE NNP cord-023095-4dannjjm 1505 21 in in IN cord-023095-4dannjjm 1505 22 Louisiana Louisiana NNP cord-023095-4dannjjm 1505 23 . . . cord-023095-4dannjjm 1506 1 Further further RB cord-023095-4dannjjm 1506 2 , , , cord-023095-4dannjjm 1506 3 this this DT cord-023095-4dannjjm 1506 4 study study NN cord-023095-4dannjjm 1506 5 failed fail VBD cord-023095-4dannjjm 1506 6 to to TO cord-023095-4dannjjm 1506 7 establish establish VB cord-023095-4dannjjm 1506 8 a a DT cord-023095-4dannjjm 1506 9 relationship relationship NN cord-023095-4dannjjm 1506 10 between between IN cord-023095-4dannjjm 1506 11 L L NNP cord-023095-4dannjjm 1506 12 intracellularis intracellularis NNP cord-023095-4dannjjm 1506 13 and and CC cord-023095-4dannjjm 1506 14 other other JJ cord-023095-4dannjjm 1506 15 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1506 16 pathogens pathogen NNS cord-023095-4dannjjm 1506 17 . . . cord-023095-4dannjjm 1507 1 The the DT cord-023095-4dannjjm 1507 2 objective objective NN cord-023095-4dannjjm 1507 3 of of IN cord-023095-4dannjjm 1507 4 this this DT cord-023095-4dannjjm 1507 5 study study NN cord-023095-4dannjjm 1507 6 was be VBD cord-023095-4dannjjm 1507 7 to to TO cord-023095-4dannjjm 1507 8 examine examine VB cord-023095-4dannjjm 1507 9 the the DT cord-023095-4dannjjm 1507 10 clinical clinical JJ cord-023095-4dannjjm 1507 11 , , , cord-023095-4dannjjm 1507 12 hematological hematological JJ cord-023095-4dannjjm 1507 13 , , , cord-023095-4dannjjm 1507 14 biochemical biochemical JJ cord-023095-4dannjjm 1507 15 , , , cord-023095-4dannjjm 1507 16 and and CC cord-023095-4dannjjm 1507 17 outcome outcome NN cord-023095-4dannjjm 1507 18 data datum NNS cord-023095-4dannjjm 1507 19 from from IN cord-023095-4dannjjm 1507 20 equids equid NNS cord-023095-4dannjjm 1507 21 infected infect VBN cord-023095-4dannjjm 1507 22 with with IN cord-023095-4dannjjm 1507 23 Anaplasma Anaplasma NNP cord-023095-4dannjjm 1507 24 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 1507 25 presented present VBD cord-023095-4dannjjm 1507 26 to to IN cord-023095-4dannjjm 1507 27 a a DT cord-023095-4dannjjm 1507 28 primary primary JJ cord-023095-4dannjjm 1507 29 care care NN cord-023095-4dannjjm 1507 30 field field NN cord-023095-4dannjjm 1507 31 setting set VBG cord-023095-4dannjjm 1507 32 in in IN cord-023095-4dannjjm 1507 33 southeastern southeastern JJ cord-023095-4dannjjm 1507 34 Pennsylvania Pennsylvania NNP cord-023095-4dannjjm 1507 35 . . . cord-023095-4dannjjm 1508 1 Computerized computerized JJ cord-023095-4dannjjm 1508 2 medical medical JJ cord-023095-4dannjjm 1508 3 records record NNS cord-023095-4dannjjm 1508 4 from from IN cord-023095-4dannjjm 1508 5 19 19 CD cord-023095-4dannjjm 1508 6 febrile febrile JJ cord-023095-4dannjjm 1508 7 equids equid NNS cord-023095-4dannjjm 1508 8 with with IN cord-023095-4dannjjm 1508 9 confirmed confirm VBN cord-023095-4dannjjm 1508 10 Anaplasma Anaplasma NNP cord-023095-4dannjjm 1508 11 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 1508 12 infection infection NN cord-023095-4dannjjm 1508 13 were be VBD cord-023095-4dannjjm 1508 14 reviewed review VBN cord-023095-4dannjjm 1508 15 . . . cord-023095-4dannjjm 1509 1 Confirmation Confirmation NNP cord-023095-4dannjjm 1509 2 of of IN cord-023095-4dannjjm 1509 3 Anaplasma Anaplasma NNP cord-023095-4dannjjm 1509 4 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 1509 5 was be VBD cord-023095-4dannjjm 1509 6 defined define VBN cord-023095-4dannjjm 1509 7 by by IN cord-023095-4dannjjm 1509 8 the the DT cord-023095-4dannjjm 1509 9 presence presence NN cord-023095-4dannjjm 1509 10 of of IN cord-023095-4dannjjm 1509 11 granular granular JJ cord-023095-4dannjjm 1509 12 inclusion inclusion NN cord-023095-4dannjjm 1509 13 bodies body NNS cord-023095-4dannjjm 1509 14 seen see VBN cord-023095-4dannjjm 1509 15 within within IN cord-023095-4dannjjm 1509 16 leukocytes leukocyte NNS cord-023095-4dannjjm 1509 17 or or CC cord-023095-4dannjjm 1509 18 eosinophils eosinophil NNS cord-023095-4dannjjm 1509 19 on on IN cord-023095-4dannjjm 1509 20 microscopic microscopic JJ cord-023095-4dannjjm 1509 21 blood blood NN cord-023095-4dannjjm 1509 22 smear smear NN cord-023095-4dannjjm 1509 23 evaluation evaluation NN cord-023095-4dannjjm 1509 24 and/or and/or CC cord-023095-4dannjjm 1509 25 a a DT cord-023095-4dannjjm 1509 26 positive positive JJ cord-023095-4dannjjm 1509 27 polymerase polymerase NN cord-023095-4dannjjm 1509 28 chain chain NN cord-023095-4dannjjm 1509 29 reaction reaction NN cord-023095-4dannjjm 1509 30 ( ( -LRB- cord-023095-4dannjjm 1509 31 PCR PCR NNP cord-023095-4dannjjm 1509 32 ) ) -RRB- cord-023095-4dannjjm 1509 33 for for IN cord-023095-4dannjjm 1509 34 Anaplasma Anaplasma NNP cord-023095-4dannjjm 1509 35 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 1509 36 . . . cord-023095-4dannjjm 1510 1 18 18 CD cord-023095-4dannjjm 1510 2 horses horse NNS cord-023095-4dannjjm 1510 3 and and CC cord-023095-4dannjjm 1510 4 1 1 CD cord-023095-4dannjjm 1510 5 donkey donkey NN cord-023095-4dannjjm 1510 6 presented present VBN cord-023095-4dannjjm 1510 7 with with IN cord-023095-4dannjjm 1510 8 a a DT cord-023095-4dannjjm 1510 9 mean mean JJ cord-023095-4dannjjm 1510 10 fever fever NN cord-023095-4dannjjm 1510 11 of of IN cord-023095-4dannjjm 1510 12 104.41F 104.41f CD cord-023095-4dannjjm 1510 13 and and CC cord-023095-4dannjjm 1510 14 mean mean VB cord-023095-4dannjjm 1510 15 fever fever NN cord-023095-4dannjjm 1510 16 duration duration NN cord-023095-4dannjjm 1510 17 of of IN cord-023095-4dannjjm 1510 18 39 39 CD cord-023095-4dannjjm 1510 19 hours hour NNS cord-023095-4dannjjm 1510 20 . . . cord-023095-4dannjjm 1511 1 The the DT cord-023095-4dannjjm 1511 2 mean mean JJ cord-023095-4dannjjm 1511 3 age age NN cord-023095-4dannjjm 1511 4 at at IN cord-023095-4dannjjm 1511 5 presentation presentation NN cord-023095-4dannjjm 1511 6 was be VBD cord-023095-4dannjjm 1511 7 9.6 9.6 CD cord-023095-4dannjjm 1511 8 years year NNS cord-023095-4dannjjm 1511 9 and and CC cord-023095-4dannjjm 1511 10 the the DT cord-023095-4dannjjm 1511 11 mean mean JJ cord-023095-4dannjjm 1511 12 pack pack NN cord-023095-4dannjjm 1511 13 cell cell NN cord-023095-4dannjjm 1511 14 volume volume NN cord-023095-4dannjjm 1511 15 was be VBD cord-023095-4dannjjm 1511 16 30.8 30.8 CD cord-023095-4dannjjm 1511 17 % % NN cord-023095-4dannjjm 1511 18 . . . cord-023095-4dannjjm 1512 1 15/19 15/19 CD cord-023095-4dannjjm 1512 2 cases case NNS cord-023095-4dannjjm 1512 3 were be VBD cord-023095-4dannjjm 1512 4 diagnosed diagnose VBN cord-023095-4dannjjm 1512 5 in in IN cord-023095-4dannjjm 1512 6 the the DT cord-023095-4dannjjm 1512 7 months month NNS cord-023095-4dannjjm 1512 8 of of IN cord-023095-4dannjjm 1512 9 May May NNP cord-023095-4dannjjm 1512 10 to to IN cord-023095-4dannjjm 1512 11 December December NNP cord-023095-4dannjjm 1512 12 . . . cord-023095-4dannjjm 1513 1 Equids Equids NNP cord-023095-4dannjjm 1513 2 ages age NNS cord-023095-4dannjjm 1513 3 5 5 CD cord-023095-4dannjjm 1513 4 to to TO cord-023095-4dannjjm 1513 5 15 15 CD cord-023095-4dannjjm 1513 6 years year NNS cord-023095-4dannjjm 1513 7 had have VBD cord-023095-4dannjjm 1513 8 significantly significantly RB cord-023095-4dannjjm 1513 9 lower low JJR cord-023095-4dannjjm 1513 10 platelet platelet NN cord-023095-4dannjjm 1513 11 counts count NNS cord-023095-4dannjjm 1513 12 . . . cord-023095-4dannjjm 1514 1 16/18 16/18 CD cord-023095-4dannjjm 1514 2 cases case NNS cord-023095-4dannjjm 1514 3 were be VBD cord-023095-4dannjjm 1514 4 positive positive JJ cord-023095-4dannjjm 1514 5 on on IN cord-023095-4dannjjm 1514 6 blood blood NN cord-023095-4dannjjm 1514 7 smear smear NN cord-023095-4dannjjm 1514 8 for for IN cord-023095-4dannjjm 1514 9 inclusion inclusion NN cord-023095-4dannjjm 1514 10 bodies body NNS cord-023095-4dannjjm 1514 11 and and CC cord-023095-4dannjjm 1514 12 6/6 6/6 CD cord-023095-4dannjjm 1514 13 cases case NNS cord-023095-4dannjjm 1514 14 were be VBD cord-023095-4dannjjm 1514 15 positive positive JJ cord-023095-4dannjjm 1514 16 for for IN cord-023095-4dannjjm 1514 17 Anaplasma Anaplasma NNP cord-023095-4dannjjm 1514 18 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 1514 19 on on IN cord-023095-4dannjjm 1514 20 PCR PCR NNP cord-023095-4dannjjm 1514 21 . . . cord-023095-4dannjjm 1515 1 Treatments treatment NNS cord-023095-4dannjjm 1515 2 included include VBD cord-023095-4dannjjm 1515 3 intravenous intravenous JJ cord-023095-4dannjjm 1515 4 oxytetracycline oxytetracycline NN cord-023095-4dannjjm 1515 5 , , , cord-023095-4dannjjm 1515 6 oral oral JJ cord-023095-4dannjjm 1515 7 doxycycline doxycycline NN cord-023095-4dannjjm 1515 8 , , , cord-023095-4dannjjm 1515 9 or or CC cord-023095-4dannjjm 1515 10 both both DT cord-023095-4dannjjm 1515 11 . . . cord-023095-4dannjjm 1516 1 Mean mean JJ cord-023095-4dannjjm 1516 2 treatment treatment NN cord-023095-4dannjjm 1516 3 duration duration NN cord-023095-4dannjjm 1516 4 was be VBD cord-023095-4dannjjm 1516 5 4.8 4.8 CD cord-023095-4dannjjm 1516 6 days day NNS cord-023095-4dannjjm 1516 7 and and CC cord-023095-4dannjjm 1516 8 mean mean VB cord-023095-4dannjjm 1516 9 treatment treatment NN cord-023095-4dannjjm 1516 10 cost cost NN cord-023095-4dannjjm 1516 11 was be VBD cord-023095-4dannjjm 1516 12 $ $ $ cord-023095-4dannjjm 1516 13 621 621 CD cord-023095-4dannjjm 1516 14 . . . cord-023095-4dannjjm 1517 1 17/19 17/19 CD cord-023095-4dannjjm 1517 2 cases case NNS cord-023095-4dannjjm 1517 3 were be VBD cord-023095-4dannjjm 1517 4 normothermic normothermic JJ cord-023095-4dannjjm 1517 5 within within IN cord-023095-4dannjjm 1517 6 48 48 CD cord-023095-4dannjjm 1517 7 hours hour NNS cord-023095-4dannjjm 1517 8 . . . cord-023095-4dannjjm 1518 1 The the DT cord-023095-4dannjjm 1518 2 treatment treatment NN cord-023095-4dannjjm 1518 3 used use VBN cord-023095-4dannjjm 1518 4 in in IN cord-023095-4dannjjm 1518 5 the the DT cord-023095-4dannjjm 1518 6 two two CD cord-023095-4dannjjm 1518 7 remaining remain VBG cord-023095-4dannjjm 1518 8 cases case NNS cord-023095-4dannjjm 1518 9 was be VBD cord-023095-4dannjjm 1518 10 changed change VBN cord-023095-4dannjjm 1518 11 from from IN cord-023095-4dannjjm 1518 12 oral oral JJ cord-023095-4dannjjm 1518 13 doxycycline doxycycline NN cord-023095-4dannjjm 1518 14 to to IN cord-023095-4dannjjm 1518 15 intravenous intravenous JJ cord-023095-4dannjjm 1518 16 oxtetracycline oxtetracycline NN cord-023095-4dannjjm 1518 17 and and CC cord-023095-4dannjjm 1518 18 was be VBD cord-023095-4dannjjm 1518 19 successful successful JJ cord-023095-4dannjjm 1518 20 . . . cord-023095-4dannjjm 1519 1 This this DT cord-023095-4dannjjm 1519 2 is be VBZ cord-023095-4dannjjm 1519 3 the the DT cord-023095-4dannjjm 1519 4 first first JJ cord-023095-4dannjjm 1519 5 case case NN cord-023095-4dannjjm 1519 6 series series NN cord-023095-4dannjjm 1519 7 of of IN cord-023095-4dannjjm 1519 8 equine equine JJ cord-023095-4dannjjm 1519 9 granulocytic granulocytic JJ cord-023095-4dannjjm 1519 10 anaplasmosis anaplasmosis NN cord-023095-4dannjjm 1519 11 in in IN cord-023095-4dannjjm 1519 12 the the DT cord-023095-4dannjjm 1519 13 mid mid JJ cord-023095-4dannjjm 1519 14 - - JJ cord-023095-4dannjjm 1519 15 Atlantic atlantic JJ cord-023095-4dannjjm 1519 16 states state NNS cord-023095-4dannjjm 1519 17 . . . cord-023095-4dannjjm 1520 1 All all DT cord-023095-4dannjjm 1520 2 cases case NNS cord-023095-4dannjjm 1520 3 were be VBD cord-023095-4dannjjm 1520 4 examined examine VBN cord-023095-4dannjjm 1520 5 and and CC cord-023095-4dannjjm 1520 6 treated treat VBN cord-023095-4dannjjm 1520 7 in in IN cord-023095-4dannjjm 1520 8 the the DT cord-023095-4dannjjm 1520 9 field field NN cord-023095-4dannjjm 1520 10 . . . cord-023095-4dannjjm 1521 1 In in IN cord-023095-4dannjjm 1521 2 order order NN cord-023095-4dannjjm 1521 3 to to TO cord-023095-4dannjjm 1521 4 make make VB cord-023095-4dannjjm 1521 5 a a DT cord-023095-4dannjjm 1521 6 definitive definitive JJ cord-023095-4dannjjm 1521 7 diagnosis diagnosis NN cord-023095-4dannjjm 1521 8 , , , cord-023095-4dannjjm 1521 9 some some DT cord-023095-4dannjjm 1521 10 cases case NNS cord-023095-4dannjjm 1521 11 required require VBD cord-023095-4dannjjm 1521 12 PCR PCR NNP cord-023095-4dannjjm 1521 13 . . . cord-023095-4dannjjm 1522 1 Treatment treatment NN cord-023095-4dannjjm 1522 2 failures failure NNS cord-023095-4dannjjm 1522 3 were be VBD cord-023095-4dannjjm 1522 4 documented document VBN cord-023095-4dannjjm 1522 5 with with IN cord-023095-4dannjjm 1522 6 the the DT cord-023095-4dannjjm 1522 7 use use NN cord-023095-4dannjjm 1522 8 of of IN cord-023095-4dannjjm 1522 9 oral oral JJ cord-023095-4dannjjm 1522 10 doxycycline doxycycline NN cord-023095-4dannjjm 1522 11 alone alone JJ cord-023095-4dannjjm 1522 12 . . . cord-023095-4dannjjm 1523 1 100 100 CD cord-023095-4dannjjm 1523 2 % % NN cord-023095-4dannjjm 1523 3 of of IN cord-023095-4dannjjm 1523 4 the the DT cord-023095-4dannjjm 1523 5 cases case NNS cord-023095-4dannjjm 1523 6 survived survive VBD cord-023095-4dannjjm 1523 7 . . . cord-023095-4dannjjm 1524 1 A a DT cord-023095-4dannjjm 1524 2 high high JJ cord-023095-4dannjjm 1524 3 incidence incidence NN cord-023095-4dannjjm 1524 4 of of IN cord-023095-4dannjjm 1524 5 clinical clinical JJ cord-023095-4dannjjm 1524 6 and and CC cord-023095-4dannjjm 1524 7 possibly possibly RB cord-023095-4dannjjm 1524 8 genetic genetic JJ cord-023095-4dannjjm 1524 9 abnormalities abnormality NNS cord-023095-4dannjjm 1524 10 has have VBZ cord-023095-4dannjjm 1524 11 been be VBN cord-023095-4dannjjm 1524 12 reported report VBN cord-023095-4dannjjm 1524 13 amongst amongst IN cord-023095-4dannjjm 1524 14 Friesian friesian JJ cord-023095-4dannjjm 1524 15 horses horse NNS cord-023095-4dannjjm 1524 16 including include VBG cord-023095-4dannjjm 1524 17 dwarfism dwarfism NN cord-023095-4dannjjm 1524 18 , , , cord-023095-4dannjjm 1524 19 hydrocephalus hydrocephalus NN cord-023095-4dannjjm 1524 20 , , , cord-023095-4dannjjm 1524 21 dissecting dissect VBG cord-023095-4dannjjm 1524 22 aortic aortic JJ cord-023095-4dannjjm 1524 23 aneurism aneurism NN cord-023095-4dannjjm 1524 24 and and CC cord-023095-4dannjjm 1524 25 esophageal esophageal JJ cord-023095-4dannjjm 1524 26 dysfunction dysfunction NN cord-023095-4dannjjm 1524 27 . . . cord-023095-4dannjjm 1525 1 The the DT cord-023095-4dannjjm 1525 2 purpose purpose NN cord-023095-4dannjjm 1525 3 of of IN cord-023095-4dannjjm 1525 4 the the DT cord-023095-4dannjjm 1525 5 current current JJ cord-023095-4dannjjm 1525 6 study study NN cord-023095-4dannjjm 1525 7 was be VBD cord-023095-4dannjjm 1525 8 to to TO cord-023095-4dannjjm 1525 9 develop develop VB cord-023095-4dannjjm 1525 10 a a DT cord-023095-4dannjjm 1525 11 new new JJ cord-023095-4dannjjm 1525 12 electromyography electromyography NN cord-023095-4dannjjm 1525 13 ( ( -LRB- cord-023095-4dannjjm 1525 14 EMG EMG NNP cord-023095-4dannjjm 1525 15 ) ) -RRB- cord-023095-4dannjjm 1525 16 method method NN cord-023095-4dannjjm 1525 17 to to TO cord-023095-4dannjjm 1525 18 assess assess VB cord-023095-4dannjjm 1525 19 neurophysiological neurophysiological JJ cord-023095-4dannjjm 1525 20 function function NN cord-023095-4dannjjm 1525 21 of of IN cord-023095-4dannjjm 1525 22 the the DT cord-023095-4dannjjm 1525 23 esophagus esophagus NN cord-023095-4dannjjm 1525 24 especially especially RB cord-023095-4dannjjm 1525 25 for for IN cord-023095-4dannjjm 1525 26 Friesian friesian JJ cord-023095-4dannjjm 1525 27 horses horse NNS cord-023095-4dannjjm 1525 28 . . . cord-023095-4dannjjm 1526 1 Five five CD cord-023095-4dannjjm 1526 2 Friesian friesian JJ cord-023095-4dannjjm 1526 3 horses horse NNS cord-023095-4dannjjm 1526 4 with with IN cord-023095-4dannjjm 1526 5 esophageal esophageal JJ cord-023095-4dannjjm 1526 6 dysfunction dysfunction NN cord-023095-4dannjjm 1526 7 were be VBD cord-023095-4dannjjm 1526 8 included include VBN cord-023095-4dannjjm 1526 9 ( ( -LRB- cord-023095-4dannjjm 1526 10 ranging range VBG cord-023095-4dannjjm 1526 11 in in IN cord-023095-4dannjjm 1526 12 age age NN cord-023095-4dannjjm 1526 13 from from IN cord-023095-4dannjjm 1526 14 0.5 0.5 CD cord-023095-4dannjjm 1526 15 - - HYPH cord-023095-4dannjjm 1526 16 24 24 CD cord-023095-4dannjjm 1526 17 years year NNS cord-023095-4dannjjm 1526 18 and and CC cord-023095-4dannjjm 1526 19 comprising comprise VBG cord-023095-4dannjjm 1526 20 4 4 CD cord-023095-4dannjjm 1526 21 mares mare NNS cord-023095-4dannjjm 1526 22 and and CC cord-023095-4dannjjm 1526 23 a a DT cord-023095-4dannjjm 1526 24 stallion stallion NN cord-023095-4dannjjm 1526 25 ) ) -RRB- cord-023095-4dannjjm 1526 26 and and CC cord-023095-4dannjjm 1526 27 two two CD cord-023095-4dannjjm 1526 28 Friesian friesian JJ cord-023095-4dannjjm 1526 29 control control NN cord-023095-4dannjjm 1526 30 horses horse NNS cord-023095-4dannjjm 1526 31 ( ( -LRB- cord-023095-4dannjjm 1526 32 a a DT cord-023095-4dannjjm 1526 33 10-and 10-and CD cord-023095-4dannjjm 1526 34 12-year 12-year JJ cord-023095-4dannjjm 1526 35 - - HYPH cord-023095-4dannjjm 1526 36 old old JJ cord-023095-4dannjjm 1526 37 gelding gelding NN cord-023095-4dannjjm 1526 38 ) ) -RRB- cord-023095-4dannjjm 1526 39 . . . cord-023095-4dannjjm 1527 1 All all DT cord-023095-4dannjjm 1527 2 five five CD cord-023095-4dannjjm 1527 3 horses horse NNS cord-023095-4dannjjm 1527 4 with with IN cord-023095-4dannjjm 1527 5 esophageal esophageal JJ cord-023095-4dannjjm 1527 6 dysfunction dysfunction NN cord-023095-4dannjjm 1527 7 had have VBD cord-023095-4dannjjm 1527 8 a a DT cord-023095-4dannjjm 1527 9 history history NN cord-023095-4dannjjm 1527 10 of of IN cord-023095-4dannjjm 1527 11 recurrent recurrent JJ cord-023095-4dannjjm 1527 12 esophageal esophageal JJ cord-023095-4dannjjm 1527 13 obstruction obstruction NN cord-023095-4dannjjm 1527 14 and and CC cord-023095-4dannjjm 1527 15 were be VBD cord-023095-4dannjjm 1527 16 examined examine VBN cord-023095-4dannjjm 1527 17 histopathologically histopathologically RB cord-023095-4dannjjm 1527 18 post post JJ cord-023095-4dannjjm 1527 19 - - NN cord-023095-4dannjjm 1527 20 mortem mortem JJ cord-023095-4dannjjm 1527 21 . . . cord-023095-4dannjjm 1528 1 Barium barium NN cord-023095-4dannjjm 1528 2 contrast contrast NN cord-023095-4dannjjm 1528 3 radiography radiography NN cord-023095-4dannjjm 1528 4 was be VBD cord-023095-4dannjjm 1528 5 used use VBN cord-023095-4dannjjm 1528 6 as as IN cord-023095-4dannjjm 1528 7 the the DT cord-023095-4dannjjm 1528 8 gold gold NN cord-023095-4dannjjm 1528 9 standard standard NN cord-023095-4dannjjm 1528 10 to to TO cord-023095-4dannjjm 1528 11 distinguish distinguish VB cord-023095-4dannjjm 1528 12 the the DT cord-023095-4dannjjm 1528 13 diseased disease VBN cord-023095-4dannjjm 1528 14 from from IN cord-023095-4dannjjm 1528 15 the the DT cord-023095-4dannjjm 1528 16 control control NN cord-023095-4dannjjm 1528 17 horses horse NNS cord-023095-4dannjjm 1528 18 . . . cord-023095-4dannjjm 1529 1 An an DT cord-023095-4dannjjm 1529 2 endoscopically endoscopically RB cord-023095-4dannjjm 1529 3 - - HYPH cord-023095-4dannjjm 1529 4 guided guide VBN cord-023095-4dannjjm 1529 5 percutaneous percutaneous JJ cord-023095-4dannjjm 1529 6 needle needle NN cord-023095-4dannjjm 1529 7 EMG EMG NNP cord-023095-4dannjjm 1529 8 procedure procedure NN cord-023095-4dannjjm 1529 9 ( ( -LRB- cord-023095-4dannjjm 1529 10 Viking Viking NNP cord-023095-4dannjjm 1529 11 Quest Quest NNP cord-023095-4dannjjm 1529 12 r r NN cord-023095-4dannjjm 1529 13 ; ; : cord-023095-4dannjjm 1529 14 software software NN cord-023095-4dannjjm 1529 15 version version NN cord-023095-4dannjjm 1529 16 11.0 11.0 CD cord-023095-4dannjjm 1529 17 ) ) -RRB- cord-023095-4dannjjm 1529 18 was be VBD cord-023095-4dannjjm 1529 19 performed perform VBN cord-023095-4dannjjm 1529 20 just just RB cord-023095-4dannjjm 1529 21 caudal caudal JJ cord-023095-4dannjjm 1529 22 to to IN cord-023095-4dannjjm 1529 23 the the DT cord-023095-4dannjjm 1529 24 larynx larynx NN cord-023095-4dannjjm 1529 25 and and CC cord-023095-4dannjjm 1529 26 just just RB cord-023095-4dannjjm 1529 27 cranial cranial JJ cord-023095-4dannjjm 1529 28 to to IN cord-023095-4dannjjm 1529 29 the the DT cord-023095-4dannjjm 1529 30 thoracic thoracic JJ cord-023095-4dannjjm 1529 31 inlet inlet NN cord-023095-4dannjjm 1529 32 ( ( -LRB- cord-023095-4dannjjm 1529 33 to to TO cord-023095-4dannjjm 1529 34 monitor monitor VB cord-023095-4dannjjm 1529 35 striated striated JJ cord-023095-4dannjjm 1529 36 and and CC cord-023095-4dannjjm 1529 37 smooth smooth JJ cord-023095-4dannjjm 1529 38 muscle muscle NN cord-023095-4dannjjm 1529 39 , , , cord-023095-4dannjjm 1529 40 respectively respectively RB cord-023095-4dannjjm 1529 41 ) ) -RRB- cord-023095-4dannjjm 1529 42 to to TO cord-023095-4dannjjm 1529 43 visualize visualize VB cord-023095-4dannjjm 1529 44 esophageal esophageal JJ cord-023095-4dannjjm 1529 45 motility motility NN cord-023095-4dannjjm 1529 46 . . . cord-023095-4dannjjm 1530 1 Esophageal esophageal JJ cord-023095-4dannjjm 1530 2 contractility contractility NN cord-023095-4dannjjm 1530 3 in in IN cord-023095-4dannjjm 1530 4 both both DT cord-023095-4dannjjm 1530 5 control control NN cord-023095-4dannjjm 1530 6 horses horse NNS cord-023095-4dannjjm 1530 7 was be VBD cord-023095-4dannjjm 1530 8 predominantly predominantly RB cord-023095-4dannjjm 1530 9 reflected reflect VBN cord-023095-4dannjjm 1530 10 by by IN cord-023095-4dannjjm 1530 11 interference interference NN cord-023095-4dannjjm 1530 12 patterns pattern NNS cord-023095-4dannjjm 1530 13 associated associate VBN cord-023095-4dannjjm 1530 14 with with IN cord-023095-4dannjjm 1530 15 longer long JJR cord-023095-4dannjjm 1530 16 duration duration NN cord-023095-4dannjjm 1530 17 and and CC cord-023095-4dannjjm 1530 18 lower low JJR cord-023095-4dannjjm 1530 19 amplitude amplitude NN cord-023095-4dannjjm 1530 20 in in IN cord-023095-4dannjjm 1530 21 smooth smooth JJ cord-023095-4dannjjm 1530 22 muscle muscle NN cord-023095-4dannjjm 1530 23 compared compare VBN cord-023095-4dannjjm 1530 24 to to IN cord-023095-4dannjjm 1530 25 striated striated JJ cord-023095-4dannjjm 1530 26 muscle muscle NN cord-023095-4dannjjm 1530 27 . . . cord-023095-4dannjjm 1531 1 Mean mean JJ cord-023095-4dannjjm 1531 2 ( ( -LRB- cord-023095-4dannjjm 1531 3 AE AE NNP cord-023095-4dannjjm 1531 4 SD SD NNP cord-023095-4dannjjm 1531 5 ) ) -RRB- cord-023095-4dannjjm 1531 6 values value NNS cord-023095-4dannjjm 1531 7 were be VBD cord-023095-4dannjjm 1531 8 35.1 35.1 CD cord-023095-4dannjjm 1531 9 AE AE NNP cord-023095-4dannjjm 1531 10 19.4 19.4 CD cord-023095-4dannjjm 1531 11 ms ms NNP cord-023095-4dannjjm 1531 12 and and CC cord-023095-4dannjjm 1531 13 167.7 167.7 CD cord-023095-4dannjjm 1531 14 AE AE NNP cord-023095-4dannjjm 1531 15 96.7 96.7 CD cord-023095-4dannjjm 1531 16 mV mV NNP cord-023095-4dannjjm 1531 17 ( ( -LRB- cord-023095-4dannjjm 1531 18 n n NN cord-023095-4dannjjm 1531 19 5 5 CD cord-023095-4dannjjm 1531 20 19 19 CD cord-023095-4dannjjm 1531 21 readings reading NNS cord-023095-4dannjjm 1531 22 ) ) -RRB- cord-023095-4dannjjm 1531 23 and and CC cord-023095-4dannjjm 1531 24 10.8 10.8 CD cord-023095-4dannjjm 1531 25 AE AE NNP cord-023095-4dannjjm 1531 26 14.3 14.3 CD cord-023095-4dannjjm 1531 27 ms ms NNP cord-023095-4dannjjm 1531 28 and and CC cord-023095-4dannjjm 1531 29 305.8 305.8 CD cord-023095-4dannjjm 1531 30 AE AE NNP cord-023095-4dannjjm 1532 1 233.7 233.7 NNP cord-023095-4dannjjm 1532 2 mV mV NNP cord-023095-4dannjjm 1532 3 ( ( -LRB- cord-023095-4dannjjm 1532 4 n n NN cord-023095-4dannjjm 1532 5 5 5 CD cord-023095-4dannjjm 1532 6 24 24 CD cord-023095-4dannjjm 1532 7 readings reading NNS cord-023095-4dannjjm 1532 8 ) ) -RRB- cord-023095-4dannjjm 1532 9 , , , cord-023095-4dannjjm 1532 10 respectively respectively RB cord-023095-4dannjjm 1532 11 . . . cord-023095-4dannjjm 1533 1 In in IN cord-023095-4dannjjm 1533 2 diseased diseased JJ cord-023095-4dannjjm 1533 3 horses horse NNS cord-023095-4dannjjm 1533 4 , , , cord-023095-4dannjjm 1533 5 aperistalsis aperistalsis NN cord-023095-4dannjjm 1533 6 in in IN cord-023095-4dannjjm 1533 7 smooth smooth JJ cord-023095-4dannjjm 1533 8 muscle muscle NN cord-023095-4dannjjm 1533 9 was be VBD cord-023095-4dannjjm 1533 10 the the DT cord-023095-4dannjjm 1533 11 most most RBS cord-023095-4dannjjm 1533 12 remarkable remarkable JJ cord-023095-4dannjjm 1533 13 finding finding NN cord-023095-4dannjjm 1533 14 suggesting suggest VBG cord-023095-4dannjjm 1533 15 a a DT cord-023095-4dannjjm 1533 16 loss loss NN cord-023095-4dannjjm 1533 17 of of IN cord-023095-4dannjjm 1533 18 inhibitory inhibitory JJ cord-023095-4dannjjm 1533 19 neurogenic neurogenic JJ cord-023095-4dannjjm 1533 20 input input NN cord-023095-4dannjjm 1533 21 resulting result VBG cord-023095-4dannjjm 1533 22 in in IN cord-023095-4dannjjm 1533 23 aperistalsis aperistalsis NN cord-023095-4dannjjm 1533 24 and and CC cord-023095-4dannjjm 1533 25 thus thus RB cord-023095-4dannjjm 1533 26 esophageal esophageal JJ cord-023095-4dannjjm 1533 27 dysfunction dysfunction NN cord-023095-4dannjjm 1533 28 . . . cord-023095-4dannjjm 1534 1 Preliminary preliminary JJ cord-023095-4dannjjm 1534 2 findings finding NNS cord-023095-4dannjjm 1534 3 suggest suggest VBP cord-023095-4dannjjm 1534 4 that that IN cord-023095-4dannjjm 1534 5 endoscopically endoscopically RB cord-023095-4dannjjm 1534 6 - - HYPH cord-023095-4dannjjm 1534 7 guided guide VBN cord-023095-4dannjjm 1534 8 percutaneous percutaneous JJ cord-023095-4dannjjm 1534 9 needle needle NN cord-023095-4dannjjm 1534 10 EMG EMG NNP cord-023095-4dannjjm 1534 11 might may MD cord-023095-4dannjjm 1534 12 become become VB cord-023095-4dannjjm 1534 13 a a DT cord-023095-4dannjjm 1534 14 valuable valuable JJ cord-023095-4dannjjm 1534 15 method method NN cord-023095-4dannjjm 1534 16 in in IN cord-023095-4dannjjm 1534 17 elucidating elucidate VBG cord-023095-4dannjjm 1534 18 the the DT cord-023095-4dannjjm 1534 19 pathophysiology pathophysiology NN cord-023095-4dannjjm 1534 20 of of IN cord-023095-4dannjjm 1534 21 dysfunction dysfunction NN cord-023095-4dannjjm 1534 22 of of IN cord-023095-4dannjjm 1534 23 esophageal esophageal JJ cord-023095-4dannjjm 1534 24 motility motility NN cord-023095-4dannjjm 1534 25 especially especially RB cord-023095-4dannjjm 1534 26 in in IN cord-023095-4dannjjm 1534 27 Friesian friesian JJ cord-023095-4dannjjm 1534 28 horses horse NNS cord-023095-4dannjjm 1534 29 . . . cord-023095-4dannjjm 1535 1 Lymphoma lymphoma NN cord-023095-4dannjjm 1535 2 affects affect VBZ cord-023095-4dannjjm 1535 3 horses horse NNS cord-023095-4dannjjm 1535 4 of of IN cord-023095-4dannjjm 1535 5 all all DT cord-023095-4dannjjm 1535 6 ages age NNS cord-023095-4dannjjm 1535 7 . . . cord-023095-4dannjjm 1536 1 Unlike unlike IN cord-023095-4dannjjm 1536 2 in in IN cord-023095-4dannjjm 1536 3 humans human NNS cord-023095-4dannjjm 1536 4 , , , cord-023095-4dannjjm 1536 5 no no DT cord-023095-4dannjjm 1536 6 etiologic etiologic JJ cord-023095-4dannjjm 1536 7 agent agent NN cord-023095-4dannjjm 1536 8 has have VBZ cord-023095-4dannjjm 1536 9 been be VBN cord-023095-4dannjjm 1536 10 discovered discover VBN cord-023095-4dannjjm 1536 11 . . . cord-023095-4dannjjm 1537 1 A a DT cord-023095-4dannjjm 1537 2 9 9 CD cord-023095-4dannjjm 1537 3 year year NN cord-023095-4dannjjm 1537 4 old old JJ cord-023095-4dannjjm 1537 5 Thoroughbred Thoroughbred NNP cord-023095-4dannjjm 1537 6 / / SYM cord-023095-4dannjjm 1537 7 Warmblood Warmblood NNP cord-023095-4dannjjm 1537 8 cross cross NN cord-023095-4dannjjm 1537 9 mare mare NN cord-023095-4dannjjm 1537 10 presented present VBN cord-023095-4dannjjm 1537 11 with with IN cord-023095-4dannjjm 1537 12 signs sign NNS cord-023095-4dannjjm 1537 13 of of IN cord-023095-4dannjjm 1537 14 upper upper JJ cord-023095-4dannjjm 1537 15 and and CC cord-023095-4dannjjm 1537 16 lower low JJR cord-023095-4dannjjm 1537 17 respiratory respiratory JJ cord-023095-4dannjjm 1537 18 disease disease NN cord-023095-4dannjjm 1537 19 and and CC cord-023095-4dannjjm 1537 20 was be VBD cord-023095-4dannjjm 1537 21 subsequently subsequently RB cord-023095-4dannjjm 1537 22 diagnosed diagnose VBN cord-023095-4dannjjm 1537 23 with with IN cord-023095-4dannjjm 1537 24 lymphoma lymphoma NN cord-023095-4dannjjm 1537 25 and and CC cord-023095-4dannjjm 1537 26 equine equine JJ cord-023095-4dannjjm 1537 27 multinodular multinodular JJ cord-023095-4dannjjm 1537 28 pulmonary pulmonary JJ cord-023095-4dannjjm 1537 29 fibrosis fibrosis NN cord-023095-4dannjjm 1537 30 ( ( -LRB- cord-023095-4dannjjm 1537 31 EMPF EMPF NNP cord-023095-4dannjjm 1537 32 ) ) -RRB- cord-023095-4dannjjm 1537 33 and and CC cord-023095-4dannjjm 1537 34 was be VBD cord-023095-4dannjjm 1537 35 positive positive JJ cord-023095-4dannjjm 1537 36 for for IN cord-023095-4dannjjm 1537 37 equine equine JJ cord-023095-4dannjjm 1537 38 herpes herpes NN cord-023095-4dannjjm 1537 39 virus virus NN cord-023095-4dannjjm 1537 40 5 5 CD cord-023095-4dannjjm 1537 41 ( ( -LRB- cord-023095-4dannjjm 1537 42 EHV-5 EHV-5 NNP cord-023095-4dannjjm 1537 43 ) ) -RRB- cord-023095-4dannjjm 1537 44 in in IN cord-023095-4dannjjm 1537 45 both both CC cord-023095-4dannjjm 1537 46 the the DT cord-023095-4dannjjm 1537 47 pulmonary pulmonary JJ cord-023095-4dannjjm 1537 48 tissue tissue NN cord-023095-4dannjjm 1537 49 and and CC cord-023095-4dannjjm 1537 50 the the DT cord-023095-4dannjjm 1537 51 lymph lymph NN cord-023095-4dannjjm 1537 52 nodes node NNS cord-023095-4dannjjm 1537 53 . . . cord-023095-4dannjjm 1538 1 Retrospective retrospective JJ cord-023095-4dannjjm 1538 2 polymerase polymerase NN cord-023095-4dannjjm 1538 3 chain chain NN cord-023095-4dannjjm 1538 4 reaction reaction NN cord-023095-4dannjjm 1538 5 ( ( -LRB- cord-023095-4dannjjm 1538 6 PCR PCR NNP cord-023095-4dannjjm 1538 7 ) ) -RRB- cord-023095-4dannjjm 1538 8 testing testing NN cord-023095-4dannjjm 1538 9 of of IN cord-023095-4dannjjm 1538 10 six six CD cord-023095-4dannjjm 1538 11 lymphoma lymphoma NN cord-023095-4dannjjm 1538 12 cases case NNS cord-023095-4dannjjm 1538 13 found find VBD cord-023095-4dannjjm 1538 14 that that IN cord-023095-4dannjjm 1538 15 5 5 CD cord-023095-4dannjjm 1538 16 of of IN cord-023095-4dannjjm 1538 17 6 6 CD cord-023095-4dannjjm 1538 18 of of IN cord-023095-4dannjjm 1538 19 the the DT cord-023095-4dannjjm 1538 20 cases case NNS cord-023095-4dannjjm 1538 21 were be VBD cord-023095-4dannjjm 1538 22 positive positive JJ cord-023095-4dannjjm 1538 23 on on IN cord-023095-4dannjjm 1538 24 PCR PCR NNP cord-023095-4dannjjm 1538 25 for for IN cord-023095-4dannjjm 1538 26 EHV-5 EHV-5 NNP cord-023095-4dannjjm 1538 27 ( ( -LRB- cord-023095-4dannjjm 1538 28 83.3 83.3 CD cord-023095-4dannjjm 1538 29 % % NN cord-023095-4dannjjm 1538 30 , , , cord-023095-4dannjjm 1538 31 p p NN cord-023095-4dannjjm 1538 32 5 5 CD cord-023095-4dannjjm 1538 33 0.0045 0.0045 CD cord-023095-4dannjjm 1538 34 , , , cord-023095-4dannjjm 1538 35 RR RR NNP cord-023095-4dannjjm 1538 36 5.55 5.55 CD cord-023095-4dannjjm 1538 37 ) ) -RRB- cord-023095-4dannjjm 1538 38 . . . cord-023095-4dannjjm 1539 1 Electron electron NN cord-023095-4dannjjm 1539 2 microscopy microscopy NN cord-023095-4dannjjm 1539 3 was be VBD cord-023095-4dannjjm 1539 4 performed perform VBN cord-023095-4dannjjm 1539 5 on on IN cord-023095-4dannjjm 1539 6 one one CD cord-023095-4dannjjm 1539 7 sample sample NN cord-023095-4dannjjm 1539 8 and and CC cord-023095-4dannjjm 1539 9 herpes herpes NN cord-023095-4dannjjm 1539 10 virus virus NN cord-023095-4dannjjm 1539 11 particles particle NNS cord-023095-4dannjjm 1539 12 were be VBD cord-023095-4dannjjm 1539 13 identified identify VBN cord-023095-4dannjjm 1539 14 . . . cord-023095-4dannjjm 1540 1 Of of IN cord-023095-4dannjjm 1540 2 the the DT cord-023095-4dannjjm 1540 3 samples sample NNS cord-023095-4dannjjm 1540 4 in in IN cord-023095-4dannjjm 1540 5 which which WDT cord-023095-4dannjjm 1540 6 immunohistochemistry immunohistochemistry NN cord-023095-4dannjjm 1540 7 was be VBD cord-023095-4dannjjm 1540 8 performed perform VBN cord-023095-4dannjjm 1540 9 ( ( -LRB- cord-023095-4dannjjm 1540 10 3 3 CD cord-023095-4dannjjm 1540 11 of of IN cord-023095-4dannjjm 1540 12 6 6 CD cord-023095-4dannjjm 1540 13 ) ) -RRB- cord-023095-4dannjjm 1540 14 , , , cord-023095-4dannjjm 1540 15 only only RB cord-023095-4dannjjm 1540 16 T t NN cord-023095-4dannjjm 1540 17 - - HYPH cord-023095-4dannjjm 1540 18 cell cell NN cord-023095-4dannjjm 1540 19 rich rich JJ cord-023095-4dannjjm 1540 20 B b NN cord-023095-4dannjjm 1540 21 - - HYPH cord-023095-4dannjjm 1540 22 cell cell NN cord-023095-4dannjjm 1540 23 lymphoma lymphoma NN cord-023095-4dannjjm 1540 24 was be VBD cord-023095-4dannjjm 1540 25 identified identify VBN cord-023095-4dannjjm 1540 26 . . . cord-023095-4dannjjm 1541 1 Samples sample NNS cord-023095-4dannjjm 1541 2 of of IN cord-023095-4dannjjm 1541 3 mesenteric mesenteric JJ cord-023095-4dannjjm 1541 4 or or CC cord-023095-4dannjjm 1541 5 submandibular submandibular JJ cord-023095-4dannjjm 1541 6 lymph lymph NN cord-023095-4dannjjm 1541 7 nodes node NNS cord-023095-4dannjjm 1541 8 from from IN cord-023095-4dannjjm 1541 9 20 20 CD cord-023095-4dannjjm 1541 10 clinically clinically RB cord-023095-4dannjjm 1541 11 healthy healthy JJ cord-023095-4dannjjm 1541 12 horses horse NNS cord-023095-4dannjjm 1541 13 were be VBD cord-023095-4dannjjm 1541 14 submitted submit VBN cord-023095-4dannjjm 1541 15 for for IN cord-023095-4dannjjm 1541 16 EHV-5 EHV-5 NNP cord-023095-4dannjjm 1541 17 PCR PCR NNP cord-023095-4dannjjm 1541 18 analysis analysis NN cord-023095-4dannjjm 1541 19 ; ; : cord-023095-4dannjjm 1541 20 15 15 CD cord-023095-4dannjjm 1541 21 % % NN cord-023095-4dannjjm 1541 22 were be VBD cord-023095-4dannjjm 1541 23 positive positive JJ cord-023095-4dannjjm 1541 24 . . . cord-023095-4dannjjm 1542 1 Gamma gamma NN cord-023095-4dannjjm 1542 2 herpesviruses herpesviruse NNS cord-023095-4dannjjm 1542 3 in in IN cord-023095-4dannjjm 1542 4 humans human NNS cord-023095-4dannjjm 1542 5 have have VBP cord-023095-4dannjjm 1542 6 been be VBN cord-023095-4dannjjm 1542 7 associated associate VBN cord-023095-4dannjjm 1542 8 with with IN cord-023095-4dannjjm 1542 9 lymphoproliferative lymphoproliferative JJ cord-023095-4dannjjm 1542 10 diseases disease NNS cord-023095-4dannjjm 1542 11 such such JJ cord-023095-4dannjjm 1542 12 as as IN cord-023095-4dannjjm 1542 13 Kaposi Kaposi NNP cord-023095-4dannjjm 1542 14 's 's POS cord-023095-4dannjjm 1542 15 sarcoma sarcoma NN cord-023095-4dannjjm 1542 16 and and CC cord-023095-4dannjjm 1542 17 Burkitt Burkitt NNP cord-023095-4dannjjm 1542 18 's 's POS cord-023095-4dannjjm 1542 19 lymphoma lymphoma NN cord-023095-4dannjjm 1542 20 . . . cord-023095-4dannjjm 1543 1 Equine equine JJ cord-023095-4dannjjm 1543 2 herpesvirus herpesvirus NN cord-023095-4dannjjm 1543 3 5 5 CD cord-023095-4dannjjm 1543 4 , , , cord-023095-4dannjjm 1543 5 also also RB cord-023095-4dannjjm 1543 6 a a DT cord-023095-4dannjjm 1543 7 gamma gamma NN cord-023095-4dannjjm 1543 8 herpesvirus herpesvirus NN cord-023095-4dannjjm 1543 9 , , , cord-023095-4dannjjm 1543 10 is be VBZ cord-023095-4dannjjm 1543 11 found find VBN cord-023095-4dannjjm 1543 12 in in IN cord-023095-4dannjjm 1543 13 association association NN cord-023095-4dannjjm 1543 14 with with IN cord-023095-4dannjjm 1543 15 equine equine JJ cord-023095-4dannjjm 1543 16 lymphoma lymphoma NN cord-023095-4dannjjm 1543 17 ; ; : cord-023095-4dannjjm 1543 18 although although IN cord-023095-4dannjjm 1543 19 the the DT cord-023095-4dannjjm 1543 20 exact exact JJ cord-023095-4dannjjm 1543 21 role role NN cord-023095-4dannjjm 1543 22 this this DT cord-023095-4dannjjm 1543 23 virus virus NN cord-023095-4dannjjm 1543 24 plays play VBZ cord-023095-4dannjjm 1543 25 in in IN cord-023095-4dannjjm 1543 26 the the DT cord-023095-4dannjjm 1543 27 initiation initiation NN cord-023095-4dannjjm 1543 28 or or CC cord-023095-4dannjjm 1543 29 perpetuation perpetuation NN cord-023095-4dannjjm 1543 30 of of IN cord-023095-4dannjjm 1543 31 lymphoproliferative lymphoproliferative JJ cord-023095-4dannjjm 1543 32 neoplasia neoplasia NN cord-023095-4dannjjm 1543 33 remains remain VBZ cord-023095-4dannjjm 1543 34 unknown unknown JJ cord-023095-4dannjjm 1543 35 . . . cord-023095-4dannjjm 1544 1 Pathologic pathologic JJ cord-023095-4dannjjm 1544 2 events event NNS cord-023095-4dannjjm 1544 3 reported report VBN cord-023095-4dannjjm 1544 4 to to TO cord-023095-4dannjjm 1544 5 occur occur VB cord-023095-4dannjjm 1544 6 in in IN cord-023095-4dannjjm 1544 7 the the DT cord-023095-4dannjjm 1544 8 digital digital JJ cord-023095-4dannjjm 1544 9 laminae laminae NN cord-023095-4dannjjm 1544 10 in in IN cord-023095-4dannjjm 1544 11 early early JJ cord-023095-4dannjjm 1544 12 stages stage NNS cord-023095-4dannjjm 1544 13 of of IN cord-023095-4dannjjm 1544 14 sepsis sepsis NN cord-023095-4dannjjm 1544 15 - - HYPH cord-023095-4dannjjm 1544 16 related relate VBN cord-023095-4dannjjm 1544 17 equine equine NN cord-023095-4dannjjm 1544 18 laminitis laminitis NN cord-023095-4dannjjm 1544 19 include include VBP cord-023095-4dannjjm 1544 20 leukocyte leukocyte NN cord-023095-4dannjjm 1544 21 extravasa extravasa NNP cord-023095-4dannjjm 1544 22 - - HYPH cord-023095-4dannjjm 1544 23 tion tion NN cord-023095-4dannjjm 1544 24 into into IN cord-023095-4dannjjm 1544 25 the the DT cord-023095-4dannjjm 1544 26 laminar laminar JJ cord-023095-4dannjjm 1544 27 interstitium interstitium NN cord-023095-4dannjjm 1544 28 , , , cord-023095-4dannjjm 1544 29 pro pro JJ cord-023095-4dannjjm 1544 30 - - JJ cord-023095-4dannjjm 1544 31 inflammatory inflammatory JJ cord-023095-4dannjjm 1544 32 cytokine cytokine NN cord-023095-4dannjjm 1544 33 expression expression NN cord-023095-4dannjjm 1544 34 , , , cord-023095-4dannjjm 1544 35 and and CC cord-023095-4dannjjm 1544 36 epithelial epithelial JJ cord-023095-4dannjjm 1544 37 stress stress NN cord-023095-4dannjjm 1544 38 . . . cord-023095-4dannjjm 1545 1 While while IN cord-023095-4dannjjm 1545 2 these these DT cord-023095-4dannjjm 1545 3 events event NNS cord-023095-4dannjjm 1545 4 have have VBP cord-023095-4dannjjm 1545 5 been be VBN cord-023095-4dannjjm 1545 6 documented document VBN cord-023095-4dannjjm 1545 7 early early RB cord-023095-4dannjjm 1545 8 in in IN cord-023095-4dannjjm 1545 9 the the DT cord-023095-4dannjjm 1545 10 disease disease NN cord-023095-4dannjjm 1545 11 process process NN cord-023095-4dannjjm 1545 12 at at IN cord-023095-4dannjjm 1545 13 both both CC cord-023095-4dannjjm 1545 14 a a DT cord-023095-4dannjjm 1545 15 developmental developmental JJ cord-023095-4dannjjm 1545 16 stage stage NN cord-023095-4dannjjm 1545 17 and and CC cord-023095-4dannjjm 1545 18 at at IN cord-023095-4dannjjm 1545 19 the the DT cord-023095-4dannjjm 1545 20 onset onset NN cord-023095-4dannjjm 1545 21 of of IN cord-023095-4dannjjm 1545 22 Obel Obel NNP cord-023095-4dannjjm 1545 23 Grade Grade NNP cord-023095-4dannjjm 1545 24 1 1 CD cord-023095-4dannjjm 1545 25 ( ( -LRB- cord-023095-4dannjjm 1545 26 OG1 OG1 NNP cord-023095-4dannjjm 1545 27 ) ) -RRB- cord-023095-4dannjjm 1545 28 lameness lameness NN cord-023095-4dannjjm 1545 29 in in IN cord-023095-4dannjjm 1545 30 the the DT cord-023095-4dannjjm 1545 31 carbohydrate carbohydrate NN cord-023095-4dannjjm 1545 32 overload overload NN cord-023095-4dannjjm 1545 33 ( ( -LRB- cord-023095-4dannjjm 1545 34 CHO CHO NNP cord-023095-4dannjjm 1545 35 ) ) -RRB- cord-023095-4dannjjm 1545 36 model model NN cord-023095-4dannjjm 1545 37 of of IN cord-023095-4dannjjm 1545 38 laminitis laminitis NN cord-023095-4dannjjm 1545 39 , , , cord-023095-4dannjjm 1545 40 the the DT cord-023095-4dannjjm 1545 41 later later JJ cord-023095-4dannjjm 1545 42 events event NNS cord-023095-4dannjjm 1545 43 occurring occur VBG cord-023095-4dannjjm 1545 44 at at IN cord-023095-4dannjjm 1545 45 the the DT cord-023095-4dannjjm 1545 46 onset onset NN cord-023095-4dannjjm 1545 47 of of IN cord-023095-4dannjjm 1545 48 Obel Obel NNP cord-023095-4dannjjm 1545 49 Grade Grade NNP cord-023095-4dannjjm 1545 50 3 3 CD cord-023095-4dannjjm 1545 51 lameness(OG3 lameness(og3 NN cord-023095-4dannjjm 1545 52 , , , cord-023095-4dannjjm 1545 53 time time NN cord-023095-4dannjjm 1545 54 point point NN cord-023095-4dannjjm 1545 55 at at IN cord-023095-4dannjjm 1545 56 which which WDT cord-023095-4dannjjm 1545 57 structural structural JJ cord-023095-4dannjjm 1545 58 failure failure NN cord-023095-4dannjjm 1545 59 of of IN cord-023095-4dannjjm 1545 60 the the DT cord-023095-4dannjjm 1545 61 laminae laminae NNP cord-023095-4dannjjm 1545 62 usually usually RB cord-023095-4dannjjm 1545 63 occurs occur VBZ cord-023095-4dannjjm 1545 64 ) ) -RRB- cord-023095-4dannjjm 1545 65 have have VBP cord-023095-4dannjjm 1545 66 not not RB cord-023095-4dannjjm 1545 67 been be VBN cord-023095-4dannjjm 1545 68 determined determine VBN cord-023095-4dannjjm 1545 69 . . . cord-023095-4dannjjm 1546 1 We -PRON- PRP cord-023095-4dannjjm 1546 2 hypothesized hypothesize VBD cord-023095-4dannjjm 1546 3 that that IN cord-023095-4dannjjm 1546 4 the the DT cord-023095-4dannjjm 1546 5 inflammatory inflammatory JJ cord-023095-4dannjjm 1546 6 events event NNS cord-023095-4dannjjm 1546 7 described describe VBN cord-023095-4dannjjm 1546 8 above above RB cord-023095-4dannjjm 1546 9 are be VBP cord-023095-4dannjjm 1546 10 sustained sustain VBN cord-023095-4dannjjm 1546 11 through through IN cord-023095-4dannjjm 1546 12 OG OG NNP cord-023095-4dannjjm 1546 13 3 3 CD cord-023095-4dannjjm 1546 14 lameness lameness NN cord-023095-4dannjjm 1546 15 , , , cord-023095-4dannjjm 1546 16 likely likely RB cord-023095-4dannjjm 1546 17 playing play VBG cord-023095-4dannjjm 1546 18 an an DT cord-023095-4dannjjm 1546 19 injurious injurious JJ cord-023095-4dannjjm 1546 20 role role NN cord-023095-4dannjjm 1546 21 culminating culminate VBG cord-023095-4dannjjm 1546 22 in in IN cord-023095-4dannjjm 1546 23 laminar laminar JJ cord-023095-4dannjjm 1546 24 failure failure NN cord-023095-4dannjjm 1546 25 . . . cord-023095-4dannjjm 1547 1 Our -PRON- PRP$ cord-023095-4dannjjm 1547 2 objectives objective NNS cord-023095-4dannjjm 1547 3 were be VBD cord-023095-4dannjjm 1547 4 to to TO cord-023095-4dannjjm 1547 5 determine determine VB cord-023095-4dannjjm 1547 6 pro pro JJ cord-023095-4dannjjm 1547 7 - - JJ cord-023095-4dannjjm 1547 8 inflammatory inflammatory JJ cord-023095-4dannjjm 1547 9 gene gene NN cord-023095-4dannjjm 1547 10 expression expression NN cord-023095-4dannjjm 1547 11 , , , cord-023095-4dannjjm 1547 12 leukocyte leukocyte NN cord-023095-4dannjjm 1547 13 extravasation extravasation NN cord-023095-4dannjjm 1547 14 , , , cord-023095-4dannjjm 1547 15 and and CC cord-023095-4dannjjm 1547 16 epithelial epithelial JJ cord-023095-4dannjjm 1547 17 stress stress NN cord-023095-4dannjjm 1547 18 at at IN cord-023095-4dannjjm 1547 19 OG OG NNP cord-023095-4dannjjm 1547 20 3 3 CD cord-023095-4dannjjm 1547 21 induced induce VBD cord-023095-4dannjjm 1547 22 using use VBG cord-023095-4dannjjm 1547 23 the the DT cord-023095-4dannjjm 1547 24 CHO CHO NNP cord-023095-4dannjjm 1547 25 model model NN cord-023095-4dannjjm 1547 26 . . . cord-023095-4dannjjm 1548 1 Archived archived JJ cord-023095-4dannjjm 1548 2 laminar laminar JJ cord-023095-4dannjjm 1548 3 tissue tissue NN cord-023095-4dannjjm 1548 4 samples sample NNS cord-023095-4dannjjm 1548 5 ( ( -LRB- cord-023095-4dannjjm 1548 6 snap snap VB cord-023095-4dannjjm 1548 7 frozen frozen JJ cord-023095-4dannjjm 1548 8 and and CC cord-023095-4dannjjm 1548 9 paraffin paraffin NN cord-023095-4dannjjm 1548 10 embedded embed VBN cord-023095-4dannjjm 1548 11 sections section NNS cord-023095-4dannjjm 1548 12 ) ) -RRB- cord-023095-4dannjjm 1548 13 were be VBD cord-023095-4dannjjm 1548 14 used use VBN cord-023095-4dannjjm 1548 15 from from IN cord-023095-4dannjjm 1548 16 a a DT cord-023095-4dannjjm 1548 17 previous previous JJ cord-023095-4dannjjm 1548 18 CHO CHO NNP cord-023095-4dannjjm 1548 19 study study NN cord-023095-4dannjjm 1548 20 at at IN cord-023095-4dannjjm 1548 21 Louisiana Louisiana NNP cord-023095-4dannjjm 1548 22 State State NNP cord-023095-4dannjjm 1548 23 University University NNP cord-023095-4dannjjm 1548 24 ( ( -LRB- cord-023095-4dannjjm 1548 25 Control Control NNP cord-023095-4dannjjm 1548 26 group group NN cord-023095-4dannjjm 1548 27 [ [ -LRB- cord-023095-4dannjjm 1548 28 n n NN cord-023095-4dannjjm 1548 29 5 5 CD cord-023095-4dannjjm 1548 30 6 6 CD cord-023095-4dannjjm 1548 31 , , , cord-023095-4dannjjm 1548 32 water water NN cord-023095-4dannjjm 1548 33 ] ] -RRB- cord-023095-4dannjjm 1548 34 , , , cord-023095-4dannjjm 1548 35 CHO CHO NNP cord-023095-4dannjjm 1548 36 group group NN cord-023095-4dannjjm 1548 37 [ [ -LRB- cord-023095-4dannjjm 1548 38 n n NN cord-023095-4dannjjm 1548 39 5 5 CD cord-023095-4dannjjm 1548 40 7 7 CD cord-023095-4dannjjm 1548 41 , , , cord-023095-4dannjjm 1548 42 corn corn NN cord-023095-4dannjjm 1548 43 starch starch NN cord-023095-4dannjjm 1548 44 ] ] -RRB- cord-023095-4dannjjm 1548 45 . . . cord-023095-4dannjjm 1549 1 Calprotectin Calprotectin NNP cord-023095-4dannjjm 1549 2 ( ( -LRB- cord-023095-4dannjjm 1549 3 CP CP NNP cord-023095-4dannjjm 1549 4 ) ) -RRB- cord-023095-4dannjjm 1549 5 immunohistochemistry immunohistochemistry NN cord-023095-4dannjjm 1549 6 ( ( -LRB- cord-023095-4dannjjm 1549 7 IHC IHC NNP cord-023095-4dannjjm 1549 8 ) ) -RRB- cord-023095-4dannjjm 1549 9 was be VBD cord-023095-4dannjjm 1549 10 used use VBN cord-023095-4dannjjm 1549 11 to to TO cord-023095-4dannjjm 1549 12 assess assess VB cord-023095-4dannjjm 1549 13 both both DT cord-023095-4dannjjm 1549 14 laminar laminar JJ cord-023095-4dannjjm 1549 15 myeloid myeloid JJ cord-023095-4dannjjm 1549 16 leukocyte leukocyte NN cord-023095-4dannjjm 1549 17 numbers number NNS cord-023095-4dannjjm 1549 18 and and CC cord-023095-4dannjjm 1549 19 epithelial epithelial JJ cord-023095-4dannjjm 1549 20 stress stress NN cord-023095-4dannjjm 1549 21 ; ; : cord-023095-4dannjjm 1549 22 RT RT NNP cord-023095-4dannjjm 1549 23 - - HYPH cord-023095-4dannjjm 1549 24 qPCR qPCR NNP cord-023095-4dannjjm 1549 25 was be VBD cord-023095-4dannjjm 1549 26 used use VBN cord-023095-4dannjjm 1549 27 to to TO cord-023095-4dannjjm 1549 28 assess assess VB cord-023095-4dannjjm 1549 29 inflammatory inflammatory JJ cord-023095-4dannjjm 1549 30 gene gene NN cord-023095-4dannjjm 1549 31 expression expression NN cord-023095-4dannjjm 1549 32 . . . cord-023095-4dannjjm 1550 1 Minimal minimal JJ cord-023095-4dannjjm 1550 2 inflammatory inflammatory JJ cord-023095-4dannjjm 1550 3 changes change NNS cord-023095-4dannjjm 1550 4 were be VBD cord-023095-4dannjjm 1550 5 present present JJ cord-023095-4dannjjm 1550 6 at at IN cord-023095-4dannjjm 1550 7 OG3 og3 NN cord-023095-4dannjjm 1550 8 compared compare VBN cord-023095-4dannjjm 1550 9 to to IN cord-023095-4dannjjm 1550 10 published publish VBN cord-023095-4dannjjm 1550 11 values value NNS cord-023095-4dannjjm 1550 12 at at IN cord-023095-4dannjjm 1550 13 OG1 OG1 NNP cord-023095-4dannjjm 1550 14 stage stage NN cord-023095-4dannjjm 1550 15 in in IN cord-023095-4dannjjm 1550 16 the the DT cord-023095-4dannjjm 1550 17 CHO CHO NNP cord-023095-4dannjjm 1550 18 lameness lameness NN cord-023095-4dannjjm 1550 19 model model NN cord-023095-4dannjjm 1550 20 including include VBG cord-023095-4dannjjm 1550 21 decreased decrease VBD cord-023095-4dannjjm 1550 22 mRNA mRNA NNP cord-023095-4dannjjm 1550 23 concentrations concentration NNS cord-023095-4dannjjm 1550 24 of of IN cord-023095-4dannjjm 1550 25 cytokines cytokine NNS cord-023095-4dannjjm 1550 26 ( ( -LRB- cord-023095-4dannjjm 1550 27 i.e. i.e. FW cord-023095-4dannjjm 1550 28 20-fold 20-fold JJ cord-023095-4dannjjm 1550 29 increase increase NN cord-023095-4dannjjm 1550 30 in in IN cord-023095-4dannjjm 1550 31 IL-6 IL-6 NNP cord-023095-4dannjjm 1550 32 at at IN cord-023095-4dannjjm 1550 33 OG3 OG3 NNP cord-023095-4dannjjm 1550 34 vs. vs. IN cord-023095-4dannjjm 1550 35 4 4 CD cord-023095-4dannjjm 1550 36 2000-fold 2000-fold CD cord-023095-4dannjjm 1550 37 increase increase NN cord-023095-4dannjjm 1550 38 at at IN cord-023095-4dannjjm 1550 39 OG1 OG1 NNP cord-023095-4dannjjm 1550 40 , , , cord-023095-4dannjjm 1550 41 no no DT cord-023095-4dannjjm 1550 42 increase increase NN cord-023095-4dannjjm 1550 43 in in IN cord-023095-4dannjjm 1550 44 IL-1b IL-1b NNS cord-023095-4dannjjm 1550 45 at at IN cord-023095-4dannjjm 1550 46 OG3 OG3 NNP cord-023095-4dannjjm 1550 47 vs. vs. IN cord-023095-4dannjjm 1550 48 11-fold 11-fold CD cord-023095-4dannjjm 1550 49 increase increase NN cord-023095-4dannjjm 1550 50 at at IN cord-023095-4dannjjm 1550 51 OG1 OG1 NNP cord-023095-4dannjjm 1550 52 ) ) -RRB- cord-023095-4dannjjm 1550 53 , , , cord-023095-4dannjjm 1550 54 chemokines chemokine NNS cord-023095-4dannjjm 1550 55 ( ( -LRB- cord-023095-4dannjjm 1550 56 no no DT cord-023095-4dannjjm 1550 57 change change NN cord-023095-4dannjjm 1550 58 in in IN cord-023095-4dannjjm 1550 59 MCP-1at MCP-1at NNP cord-023095-4dannjjm 1550 60 OG3 OG3 NNP cord-023095-4dannjjm 1550 61 vs. vs. IN cord-023095-4dannjjm 1550 62 4 4 CD cord-023095-4dannjjm 1550 63 30 30 CD cord-023095-4dannjjm 1550 64 fold fold NN cord-023095-4dannjjm 1550 65 increase increase NN cord-023095-4dannjjm 1550 66 at at IN cord-023095-4dannjjm 1550 67 OG1 OG1 NNP cord-023095-4dannjjm 1550 68 , , , cord-023095-4dannjjm 1551 1 8-fold 8-fold JJ cord-023095-4dannjjm 1551 2 increase increase NN cord-023095-4dannjjm 1551 3 in in IN cord-023095-4dannjjm 1551 4 IL-8 IL-8 NNP cord-023095-4dannjjm 1551 5 at at IN cord-023095-4dannjjm 1551 6 OG3 og3 NN cord-023095-4dannjjm 1551 7 vs. vs. FW cord-023095-4dannjjm 1551 8 95fold 95fold CD cord-023095-4dannjjm 1551 9 increase increase NN cord-023095-4dannjjm 1551 10 at at IN cord-023095-4dannjjm 1551 11 OG1 OG1 NNP cord-023095-4dannjjm 1551 12 ) ) -RRB- cord-023095-4dannjjm 1551 13 and and CC cord-023095-4dannjjm 1551 14 adhesion adhesion NN cord-023095-4dannjjm 1551 15 molecules molecule NNS cord-023095-4dannjjm 1551 16 ( ( -LRB- cord-023095-4dannjjm 1551 17 no no DT cord-023095-4dannjjm 1551 18 change change NN cord-023095-4dannjjm 1551 19 in in IN cord-023095-4dannjjm 1551 20 E e NN cord-023095-4dannjjm 1551 21 - - NN cord-023095-4dannjjm 1551 22 selectin selectin NN cord-023095-4dannjjm 1551 23 at at IN cord-023095-4dannjjm 1551 24 OG3 og3 NN cord-023095-4dannjjm 1551 25 vs. vs. IN cord-023095-4dannjjm 1551 26 10-fold 10-fold CD cord-023095-4dannjjm 1551 27 increase increase NN cord-023095-4dannjjm 1551 28 at at IN cord-023095-4dannjjm 1551 29 OG1 OG1 NNP cord-023095-4dannjjm 1551 30 ) ) -RRB- cord-023095-4dannjjm 1551 31 . . . cord-023095-4dannjjm 1552 1 Laminar laminar JJ cord-023095-4dannjjm 1552 2 leukocyte leukocyte NN cord-023095-4dannjjm 1552 3 emigration emigration NN cord-023095-4dannjjm 1552 4 was be VBD cord-023095-4dannjjm 1552 5 also also RB cord-023095-4dannjjm 1552 6 decreased decrease VBN cord-023095-4dannjjm 1552 7 at at IN cord-023095-4dannjjm 1552 8 the the DT cord-023095-4dannjjm 1552 9 onset onset NN cord-023095-4dannjjm 1552 10 of of IN cord-023095-4dannjjm 1552 11 OG OG NNP cord-023095-4dannjjm 1552 12 3 3 CD cord-023095-4dannjjm 1552 13 lameness lameness NN cord-023095-4dannjjm 1552 14 compared compare VBN cord-023095-4dannjjm 1552 15 to to IN cord-023095-4dannjjm 1552 16 previously previously RB cord-023095-4dannjjm 1552 17 reported report VBN cord-023095-4dannjjm 1552 18 leukocyte leukocyte NN cord-023095-4dannjjm 1552 19 infiltration infiltration NN cord-023095-4dannjjm 1552 20 at at IN cord-023095-4dannjjm 1552 21 OG OG NNP cord-023095-4dannjjm 1552 22 1 1 CD cord-023095-4dannjjm 1552 23 . . . cord-023095-4dannjjm 1553 1 Interestingly interestingly RB cord-023095-4dannjjm 1553 2 COX-2 COX-2 NNP cord-023095-4dannjjm 1553 3 , , , cord-023095-4dannjjm 1553 4 underwent undergo VBD cord-023095-4dannjjm 1553 5 a a DT cord-023095-4dannjjm 1553 6 greater great JJR cord-023095-4dannjjm 1553 7 increase increase NN cord-023095-4dannjjm 1553 8 at at IN cord-023095-4dannjjm 1553 9 OG3 og3 NN cord-023095-4dannjjm 1553 10 ( ( -LRB- cord-023095-4dannjjm 1553 11 approx approx NN cord-023095-4dannjjm 1553 12 . . . cord-023095-4dannjjm 1553 13 50-fold 50-fold CD cord-023095-4dannjjm 1553 14 ) ) -RRB- cord-023095-4dannjjm 1554 1 compared compare VBN cord-023095-4dannjjm 1554 2 to to IN cord-023095-4dannjjm 1554 3 that that DT cord-023095-4dannjjm 1554 4 reported report VBN cord-023095-4dannjjm 1554 5 at at IN cord-023095-4dannjjm 1554 6 OG1 OG1 NNP cord-023095-4dannjjm 1554 7 lameness lameness NN cord-023095-4dannjjm 1554 8 ( ( -LRB- cord-023095-4dannjjm 1554 9 35-fold 35-fold CD cord-023095-4dannjjm 1554 10 ) ) -RRB- cord-023095-4dannjjm 1554 11 . . . cord-023095-4dannjjm 1555 1 Finally finally RB cord-023095-4dannjjm 1555 2 , , , cord-023095-4dannjjm 1555 3 epithelial epithelial JJ cord-023095-4dannjjm 1555 4 stress stress NN cord-023095-4dannjjm 1555 5 at at IN cord-023095-4dannjjm 1555 6 OG3 OG3 NNP cord-023095-4dannjjm 1555 7 evidenced evidence VBN cord-023095-4dannjjm 1555 8 by by IN cord-023095-4dannjjm 1555 9 CP CP NNP cord-023095-4dannjjm 1555 10 IHC IHC NNP cord-023095-4dannjjm 1555 11 did do VBD cord-023095-4dannjjm 1555 12 not not RB cord-023095-4dannjjm 1555 13 follow follow VB cord-023095-4dannjjm 1555 14 the the DT cord-023095-4dannjjm 1555 15 uniform uniform JJ cord-023095-4dannjjm 1555 16 widespread widespread JJ cord-023095-4dannjjm 1555 17 distribution distribution NN cord-023095-4dannjjm 1555 18 reported report VBN cord-023095-4dannjjm 1555 19 at at IN cord-023095-4dannjjm 1555 20 OG1 OG1 NNP cord-023095-4dannjjm 1555 21 lameness lameness NN cord-023095-4dannjjm 1555 22 , , , cord-023095-4dannjjm 1555 23 but but CC cord-023095-4dannjjm 1555 24 instead instead RB cord-023095-4dannjjm 1555 25 was be VBD cord-023095-4dannjjm 1555 26 present present JJ cord-023095-4dannjjm 1555 27 in in IN cord-023095-4dannjjm 1555 28 focal focal JJ cord-023095-4dannjjm 1555 29 areas area NNS cord-023095-4dannjjm 1555 30 in in IN cord-023095-4dannjjm 1555 31 which which WDT cord-023095-4dannjjm 1555 32 secondary secondary JJ cord-023095-4dannjjm 1555 33 epidermal epidermal JJ cord-023095-4dannjjm 1555 34 laminae laminae RB cord-023095-4dannjjm 1555 35 on on IN cord-023095-4dannjjm 1555 36 either either DT cord-023095-4dannjjm 1555 37 side side NN cord-023095-4dannjjm 1555 38 of of IN cord-023095-4dannjjm 1555 39 a a DT cord-023095-4dannjjm 1555 40 common common JJ cord-023095-4dannjjm 1555 41 primary primary JJ cord-023095-4dannjjm 1555 42 dermal dermal JJ cord-023095-4dannjjm 1555 43 vascular vascular JJ cord-023095-4dannjjm 1555 44 supply supply NN cord-023095-4dannjjm 1556 1 demonstrated demonstrate VBN cord-023095-4dannjjm 1556 2 increased increased JJ cord-023095-4dannjjm 1556 3 CP cp NN cord-023095-4dannjjm 1556 4 signal signal NN cord-023095-4dannjjm 1556 5 . . . cord-023095-4dannjjm 1557 1 Overall overall RB cord-023095-4dannjjm 1557 2 , , , cord-023095-4dannjjm 1557 3 laminar laminar JJ cord-023095-4dannjjm 1557 4 inflammation inflammation NN cord-023095-4dannjjm 1557 5 appears appear VBZ cord-023095-4dannjjm 1557 6 to to TO cord-023095-4dannjjm 1557 7 be be VB cord-023095-4dannjjm 1557 8 subsiding subside VBG cord-023095-4dannjjm 1557 9 at at IN cord-023095-4dannjjm 1557 10 OG3 og3 JJ cord-023095-4dannjjm 1557 11 lameness lameness NN cord-023095-4dannjjm 1557 12 , , , cord-023095-4dannjjm 1557 13 with with IN cord-023095-4dannjjm 1557 14 epithelial epithelial JJ cord-023095-4dannjjm 1557 15 stress stress NN cord-023095-4dannjjm 1557 16 possibly possibly RB cord-023095-4dannjjm 1557 17 more more RBR cord-023095-4dannjjm 1557 18 dependent dependent JJ cord-023095-4dannjjm 1557 19 on on IN cord-023095-4dannjjm 1557 20 vascular vascular JJ cord-023095-4dannjjm 1557 21 dysregulation dysregulation NN cord-023095-4dannjjm 1557 22 instead instead RB cord-023095-4dannjjm 1557 23 of of IN cord-023095-4dannjjm 1557 24 inflammatory inflammatory JJ cord-023095-4dannjjm 1557 25 events event NNS cord-023095-4dannjjm 1557 26 . . . cord-023095-4dannjjm 1558 1 The the DT cord-023095-4dannjjm 1558 2 sustained sustained JJ cord-023095-4dannjjm 1558 3 increase increase NN cord-023095-4dannjjm 1558 4 in in IN cord-023095-4dannjjm 1558 5 COX-2 COX-2 NNP cord-023095-4dannjjm 1558 6 , , , cord-023095-4dannjjm 1558 7 central central JJ cord-023095-4dannjjm 1558 8 to to IN cord-023095-4dannjjm 1558 9 the the DT cord-023095-4dannjjm 1558 10 induced induce VBN cord-023095-4dannjjm 1558 11 production production NN cord-023095-4dannjjm 1558 12 of of IN cord-023095-4dannjjm 1558 13 vasoactive vasoactive JJ cord-023095-4dannjjm 1558 14 prostanoids prostanoid NNS cord-023095-4dannjjm 1558 15 in in IN cord-023095-4dannjjm 1558 16 disease disease NN cord-023095-4dannjjm 1558 17 processes process NNS cord-023095-4dannjjm 1558 18 , , , cord-023095-4dannjjm 1558 19 may may MD cord-023095-4dannjjm 1558 20 play play VB cord-023095-4dannjjm 1558 21 a a DT cord-023095-4dannjjm 1558 22 role role NN cord-023095-4dannjjm 1558 23 in in IN cord-023095-4dannjjm 1558 24 vascular vascular JJ cord-023095-4dannjjm 1558 25 dysregulation dysregulation NN cord-023095-4dannjjm 1558 26 . . . cord-023095-4dannjjm 1559 1 This this DT cord-023095-4dannjjm 1559 2 study study NN cord-023095-4dannjjm 1559 3 was be VBD cord-023095-4dannjjm 1559 4 conducted conduct VBN cord-023095-4dannjjm 1559 5 to to TO cord-023095-4dannjjm 1559 6 characterize characterize VB cord-023095-4dannjjm 1559 7 clinical clinical JJ cord-023095-4dannjjm 1559 8 , , , cord-023095-4dannjjm 1559 9 laboratory laboratory NN cord-023095-4dannjjm 1559 10 and and CC cord-023095-4dannjjm 1559 11 postmortem postmortem JJ cord-023095-4dannjjm 1559 12 findings finding NNS cord-023095-4dannjjm 1559 13 associated associate VBN cord-023095-4dannjjm 1559 14 with with IN cord-023095-4dannjjm 1559 15 oleander oleander NN cord-023095-4dannjjm 1559 16 toxicosis toxicosis NN cord-023095-4dannjjm 1559 17 in in IN cord-023095-4dannjjm 1559 18 equids equid NNS cord-023095-4dannjjm 1559 19 and and CC cord-023095-4dannjjm 1559 20 to to TO cord-023095-4dannjjm 1559 21 determine determine VB cord-023095-4dannjjm 1559 22 factors factor NNS cord-023095-4dannjjm 1559 23 predictive predictive JJ cord-023095-4dannjjm 1559 24 of of IN cord-023095-4dannjjm 1559 25 survival survival NN cord-023095-4dannjjm 1559 26 in in IN cord-023095-4dannjjm 1559 27 these these DT cord-023095-4dannjjm 1559 28 cases case NNS cord-023095-4dannjjm 1559 29 . . . cord-023095-4dannjjm 1560 1 Retrospective retrospective JJ cord-023095-4dannjjm 1560 2 analysis analysis NN cord-023095-4dannjjm 1560 3 of of IN cord-023095-4dannjjm 1560 4 medical medical JJ cord-023095-4dannjjm 1560 5 records record NNS cord-023095-4dannjjm 1560 6 from from IN cord-023095-4dannjjm 1560 7 our -PRON- PRP$ cord-023095-4dannjjm 1560 8 veterinary veterinary JJ cord-023095-4dannjjm 1560 9 medical medical JJ cord-023095-4dannjjm 1560 10 teaching teaching NN cord-023095-4dannjjm 1560 11 hospital hospital NN cord-023095-4dannjjm 1560 12 from from IN cord-023095-4dannjjm 1560 13 January January NNP cord-023095-4dannjjm 1560 14 1 1 CD cord-023095-4dannjjm 1560 15 , , , cord-023095-4dannjjm 1560 16 1995 1995 CD cord-023095-4dannjjm 1560 17 to to IN cord-023095-4dannjjm 1560 18 July July NNP cord-023095-4dannjjm 1560 19 15 15 CD cord-023095-4dannjjm 1560 20 , , , cord-023095-4dannjjm 1560 21 2010 2010 CD cord-023095-4dannjjm 1560 22 was be VBD cord-023095-4dannjjm 1560 23 completed complete VBN cord-023095-4dannjjm 1560 24 . . . cord-023095-4dannjjm 1561 1 Records record NNS cord-023095-4dannjjm 1561 2 of of IN cord-023095-4dannjjm 1561 3 equids equid NNS cord-023095-4dannjjm 1561 4 demonstrating demonstrate VBG cord-023095-4dannjjm 1561 5 detectable detectable JJ cord-023095-4dannjjm 1561 6 oleandrin oleandrin NN cord-023095-4dannjjm 1561 7 in in IN cord-023095-4dannjjm 1561 8 serum serum NN cord-023095-4dannjjm 1561 9 , , , cord-023095-4dannjjm 1561 10 plasma plasma NN cord-023095-4dannjjm 1561 11 , , , cord-023095-4dannjjm 1561 12 urine urine NN cord-023095-4dannjjm 1561 13 or or CC cord-023095-4dannjjm 1561 14 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1561 15 fluid fluid JJ cord-023095-4dannjjm 1561 16 samples sample NNS cord-023095-4dannjjm 1561 17 or or CC cord-023095-4dannjjm 1561 18 detectable detectable JJ cord-023095-4dannjjm 1561 19 serum serum NN cord-023095-4dannjjm 1561 20 digoxin digoxin NN cord-023095-4dannjjm 1561 21 in in IN cord-023095-4dannjjm 1561 22 the the DT cord-023095-4dannjjm 1561 23 absence absence NN cord-023095-4dannjjm 1561 24 of of IN cord-023095-4dannjjm 1561 25 pharmaceutical pharmaceutical JJ cord-023095-4dannjjm 1561 26 cardiac cardiac JJ cord-023095-4dannjjm 1561 27 glycoside glycoside NN cord-023095-4dannjjm 1561 28 administration administration NNP cord-023095-4dannjjm 1561 29 were be VBD cord-023095-4dannjjm 1561 30 included include VBN cord-023095-4dannjjm 1561 31 . . . cord-023095-4dannjjm 1562 1 Descriptive descriptive JJ cord-023095-4dannjjm 1562 2 statistics statistic NNS cord-023095-4dannjjm 1562 3 were be VBD cord-023095-4dannjjm 1562 4 used use VBN cord-023095-4dannjjm 1562 5 to to TO cord-023095-4dannjjm 1562 6 evaluate evaluate VB cord-023095-4dannjjm 1562 7 the the DT cord-023095-4dannjjm 1562 8 history history NN cord-023095-4dannjjm 1562 9 , , , cord-023095-4dannjjm 1562 10 physical physical JJ cord-023095-4dannjjm 1562 11 examination examination NN cord-023095-4dannjjm 1562 12 , , , cord-023095-4dannjjm 1562 13 and and CC cord-023095-4dannjjm 1562 14 laboratory laboratory NN cord-023095-4dannjjm 1562 15 and and CC cord-023095-4dannjjm 1562 16 postmortem postmortem JJ cord-023095-4dannjjm 1562 17 data datum NNS cord-023095-4dannjjm 1562 18 of of IN cord-023095-4dannjjm 1562 19 affected affect VBN cord-023095-4dannjjm 1562 20 individuals individual NNS cord-023095-4dannjjm 1562 21 . . . cord-023095-4dannjjm 1563 1 Logistic logistic JJ cord-023095-4dannjjm 1563 2 regression regression NN cord-023095-4dannjjm 1563 3 analysis analysis NN cord-023095-4dannjjm 1563 4 was be VBD cord-023095-4dannjjm 1563 5 used use VBN cord-023095-4dannjjm 1563 6 to to TO cord-023095-4dannjjm 1563 7 detect detect VB cord-023095-4dannjjm 1563 8 physical physical JJ cord-023095-4dannjjm 1563 9 examination examination NN cord-023095-4dannjjm 1563 10 and and CC cord-023095-4dannjjm 1563 11 laboratory laboratory NN cord-023095-4dannjjm 1563 12 factors factor NNS cord-023095-4dannjjm 1563 13 significantly significantly RB cord-023095-4dannjjm 1563 14 associated associate VBN cord-023095-4dannjjm 1563 15 with with IN cord-023095-4dannjjm 1563 16 survival survival NN cord-023095-4dannjjm 1563 17 . . . cord-023095-4dannjjm 1564 1 Thirty thirty CD cord-023095-4dannjjm 1564 2 equids equid NNS cord-023095-4dannjjm 1564 3 met meet VBD cord-023095-4dannjjm 1564 4 inclusion inclusion NN cord-023095-4dannjjm 1564 5 criteria criterion NNS cord-023095-4dannjjm 1564 6 of of IN cord-023095-4dannjjm 1564 7 the the DT cord-023095-4dannjjm 1564 8 study study NN cord-023095-4dannjjm 1564 9 . . . cord-023095-4dannjjm 1565 1 Three three CD cord-023095-4dannjjm 1565 2 of of IN cord-023095-4dannjjm 1565 3 30 30 CD cord-023095-4dannjjm 1565 4 subjects subject NNS cord-023095-4dannjjm 1565 5 were be VBD cord-023095-4dannjjm 1565 6 dead dead JJ cord-023095-4dannjjm 1565 7 on on IN cord-023095-4dannjjm 1565 8 arrival arrival NN cord-023095-4dannjjm 1565 9 or or CC cord-023095-4dannjjm 1565 10 died die VBD cord-023095-4dannjjm 1565 11 immediately immediately RB cord-023095-4dannjjm 1565 12 upon upon IN cord-023095-4dannjjm 1565 13 arrival arrival NN cord-023095-4dannjjm 1565 14 ( ( -LRB- cord-023095-4dannjjm 1565 15 10 10 CD cord-023095-4dannjjm 1565 16 % % NN cord-023095-4dannjjm 1565 17 ) ) -RRB- cord-023095-4dannjjm 1565 18 . . . cord-023095-4dannjjm 1566 1 Of of IN cord-023095-4dannjjm 1566 2 the the DT cord-023095-4dannjjm 1566 3 remaining remain VBG cord-023095-4dannjjm 1566 4 27 27 CD cord-023095-4dannjjm 1566 5 equids equid NNS cord-023095-4dannjjm 1566 6 , , , cord-023095-4dannjjm 1566 7 85 85 CD cord-023095-4dannjjm 1566 8 % % NN cord-023095-4dannjjm 1566 9 presented present VBN cord-023095-4dannjjm 1566 10 with with IN cord-023095-4dannjjm 1566 11 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1566 12 abnormalities abnormality NNS cord-023095-4dannjjm 1566 13 , , , cord-023095-4dannjjm 1566 14 70 70 CD cord-023095-4dannjjm 1566 15 % % NN cord-023095-4dannjjm 1566 16 were be VBD cord-023095-4dannjjm 1566 17 azotemic azotemic JJ cord-023095-4dannjjm 1566 18 and and CC cord-023095-4dannjjm 1566 19 48 48 CD cord-023095-4dannjjm 1566 20 % % NN cord-023095-4dannjjm 1566 21 had have VBD cord-023095-4dannjjm 1566 22 cardiac cardiac JJ cord-023095-4dannjjm 1566 23 arrhythmias arrhythmia NNS cord-023095-4dannjjm 1566 24 . . . cord-023095-4dannjjm 1567 1 Mortality mortality NN cord-023095-4dannjjm 1567 2 was be VBD cord-023095-4dannjjm 1567 3 50 50 CD cord-023095-4dannjjm 1567 4 % % NN cord-023095-4dannjjm 1567 5 for for IN cord-023095-4dannjjm 1567 6 all all DT cord-023095-4dannjjm 1567 7 subjects subject NNS cord-023095-4dannjjm 1567 8 and and CC cord-023095-4dannjjm 1567 9 44 44 CD cord-023095-4dannjjm 1567 10 % % NN cord-023095-4dannjjm 1567 11 for for IN cord-023095-4dannjjm 1567 12 those those DT cord-023095-4dannjjm 1567 13 treated treat VBN cord-023095-4dannjjm 1567 14 . . . cord-023095-4dannjjm 1568 1 The the DT cord-023095-4dannjjm 1568 2 predominant predominant JJ cord-023095-4dannjjm 1568 3 cause cause NN cord-023095-4dannjjm 1568 4 for for IN cord-023095-4dannjjm 1568 5 non non JJ cord-023095-4dannjjm 1568 6 - - JJ cord-023095-4dannjjm 1568 7 survival survival JJ cord-023095-4dannjjm 1568 8 was be VBD cord-023095-4dannjjm 1568 9 cardiac cardiac JJ cord-023095-4dannjjm 1568 10 dysfunction dysfunction NN cord-023095-4dannjjm 1568 11 . . . cord-023095-4dannjjm 1569 1 Factors factor NNS cord-023095-4dannjjm 1569 2 significantly significantly RB cord-023095-4dannjjm 1569 3 associated associate VBD cord-023095-4dannjjm 1569 4 with with IN cord-023095-4dannjjm 1569 5 survival survival NN cord-023095-4dannjjm 1569 6 included include VBD cord-023095-4dannjjm 1569 7 relatively relatively RB cord-023095-4dannjjm 1569 8 decreased decrease VBD cord-023095-4dannjjm 1569 9 hematocrit hematocrit NN cord-023095-4dannjjm 1569 10 and and CC cord-023095-4dannjjm 1569 11 serum serum NN cord-023095-4dannjjm 1569 12 glucose glucose NN cord-023095-4dannjjm 1569 13 , , , cord-023095-4dannjjm 1569 14 relatively relatively RB cord-023095-4dannjjm 1569 15 increased increase VBN cord-023095-4dannjjm 1569 16 serum serum NN cord-023095-4dannjjm 1569 17 chloride chloride NN cord-023095-4dannjjm 1569 18 , , , cord-023095-4dannjjm 1569 19 absence absence NN cord-023095-4dannjjm 1569 20 of of IN cord-023095-4dannjjm 1569 21 cardiac cardiac JJ cord-023095-4dannjjm 1569 22 arrhythmias arrhythmia NNS cord-023095-4dannjjm 1569 23 , , , cord-023095-4dannjjm 1569 24 and and CC cord-023095-4dannjjm 1569 25 increased increase VBN cord-023095-4dannjjm 1569 26 duration duration NN cord-023095-4dannjjm 1569 27 of of IN cord-023095-4dannjjm 1569 28 hospitalization hospitalization NN cord-023095-4dannjjm 1569 29 . . . cord-023095-4dannjjm 1570 1 Equids Equids NNP cord-023095-4dannjjm 1570 2 with with IN cord-023095-4dannjjm 1570 3 oleander oleander NN cord-023095-4dannjjm 1570 4 toxicosis toxicosis NN cord-023095-4dannjjm 1570 5 frequently frequently RB cord-023095-4dannjjm 1570 6 present present VBP cord-023095-4dannjjm 1570 7 with with IN cord-023095-4dannjjm 1570 8 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1570 9 upset upset NN cord-023095-4dannjjm 1570 10 and and CC cord-023095-4dannjjm 1570 11 may may MD cord-023095-4dannjjm 1570 12 develop develop VB cord-023095-4dannjjm 1570 13 cardiac cardiac JJ cord-023095-4dannjjm 1570 14 and and CC cord-023095-4dannjjm 1570 15 renal renal JJ cord-023095-4dannjjm 1570 16 disturbances disturbance NNS cord-023095-4dannjjm 1570 17 . . . cord-023095-4dannjjm 1571 1 Patients patient NNS cord-023095-4dannjjm 1571 2 with with IN cord-023095-4dannjjm 1571 3 cardiac cardiac JJ cord-023095-4dannjjm 1571 4 arrhythmias arrhythmia NNS cord-023095-4dannjjm 1571 5 and and CC cord-023095-4dannjjm 1571 6 relatively relatively RB cord-023095-4dannjjm 1571 7 increased increase VBN cord-023095-4dannjjm 1571 8 hematocrit hematocrit NN cord-023095-4dannjjm 1571 9 and and CC cord-023095-4dannjjm 1571 10 serum serum NN cord-023095-4dannjjm 1571 11 glucose glucose NN cord-023095-4dannjjm 1571 12 and and CC cord-023095-4dannjjm 1571 13 decreased decrease VBD cord-023095-4dannjjm 1571 14 serum serum NN cord-023095-4dannjjm 1571 15 chloride chloride NN cord-023095-4dannjjm 1571 16 are be VBP cord-023095-4dannjjm 1571 17 significantly significantly RB cord-023095-4dannjjm 1571 18 less less RBR cord-023095-4dannjjm 1571 19 likely likely JJ cord-023095-4dannjjm 1571 20 to to TO cord-023095-4dannjjm 1571 21 survive survive VB cord-023095-4dannjjm 1571 22 . . . cord-023095-4dannjjm 1572 1 Oleander oleander NN cord-023095-4dannjjm 1572 2 intoxication intoxication NN cord-023095-4dannjjm 1572 3 is be VBZ cord-023095-4dannjjm 1572 4 a a DT cord-023095-4dannjjm 1572 5 differential differential JJ cord-023095-4dannjjm 1572 6 diagnosis diagnosis NN cord-023095-4dannjjm 1572 7 for for IN cord-023095-4dannjjm 1572 8 colic colic NN cord-023095-4dannjjm 1572 9 in in IN cord-023095-4dannjjm 1572 10 endemic endemic JJ cord-023095-4dannjjm 1572 11 areas area NNS cord-023095-4dannjjm 1572 12 , , , cord-023095-4dannjjm 1572 13 particularly particularly RB cord-023095-4dannjjm 1572 14 with with IN cord-023095-4dannjjm 1572 15 concurrent concurrent JJ cord-023095-4dannjjm 1572 16 azotemia azotemia NN cord-023095-4dannjjm 1572 17 or or CC cord-023095-4dannjjm 1572 18 cardiac cardiac JJ cord-023095-4dannjjm 1572 19 dysrhythmia dysrhythmia NN cord-023095-4dannjjm 1572 20 . . . cord-023095-4dannjjm 1573 1 The the DT cord-023095-4dannjjm 1573 2 quantitative quantitative JJ cord-023095-4dannjjm 1573 3 physicochemical physicochemical JJ cord-023095-4dannjjm 1573 4 approach approach NN cord-023095-4dannjjm 1573 5 emphasizes emphasize VBZ cord-023095-4dannjjm 1573 6 the the DT cord-023095-4dannjjm 1573 7 importance importance NN cord-023095-4dannjjm 1573 8 of of IN cord-023095-4dannjjm 1573 9 strong strong JJ cord-023095-4dannjjm 1573 10 ions ion NNS cord-023095-4dannjjm 1573 11 ( ( -LRB- cord-023095-4dannjjm 1573 12 Na na UH cord-023095-4dannjjm 1573 13 , , , cord-023095-4dannjjm 1573 14 K K NNP cord-023095-4dannjjm 1573 15 , , , cord-023095-4dannjjm 1573 16 Cl Cl NNP cord-023095-4dannjjm 1573 17 , , , cord-023095-4dannjjm 1573 18 lactate lactate NN cord-023095-4dannjjm 1573 19 ) ) -RRB- cord-023095-4dannjjm 1573 20 , , , cord-023095-4dannjjm 1573 21 pCO pCO NNP cord-023095-4dannjjm 1573 22 2 2 CD cord-023095-4dannjjm 1573 23 , , , cord-023095-4dannjjm 1573 24 and and CC cord-023095-4dannjjm 1573 25 the the DT cord-023095-4dannjjm 1573 26 plasma plasma NN cord-023095-4dannjjm 1573 27 protein protein NN cord-023095-4dannjjm 1573 28 concentrations concentration NNS cord-023095-4dannjjm 1573 29 in in IN cord-023095-4dannjjm 1573 30 determining determine VBG cord-023095-4dannjjm 1573 31 plasma plasma NN cord-023095-4dannjjm 1573 32 pH. ph. NN cord-023095-4dannjjm 1573 33 Serum Serum NNP cord-023095-4dannjjm 1573 34 concentrations concentration NNS cord-023095-4dannjjm 1573 35 of of IN cord-023095-4dannjjm 1573 36 strong strong JJ cord-023095-4dannjjm 1573 37 ions ion NNS cord-023095-4dannjjm 1573 38 , , , cord-023095-4dannjjm 1573 39 proteins protein NNS cord-023095-4dannjjm 1573 40 , , , cord-023095-4dannjjm 1573 41 and and CC cord-023095-4dannjjm 1573 42 total total JJ cord-023095-4dannjjm 1573 43 CO CO NNP cord-023095-4dannjjm 1573 44 2 2 CD cord-023095-4dannjjm 1573 45 are be VBP cord-023095-4dannjjm 1573 46 reported report VBN cord-023095-4dannjjm 1573 47 on on IN cord-023095-4dannjjm 1573 48 modern modern JJ cord-023095-4dannjjm 1573 49 biochemical biochemical JJ cord-023095-4dannjjm 1573 50 profiles profile NNS cord-023095-4dannjjm 1573 51 . . . cord-023095-4dannjjm 1574 1 We -PRON- PRP cord-023095-4dannjjm 1574 2 hypothesized hypothesize VBD cord-023095-4dannjjm 1574 3 that that IN cord-023095-4dannjjm 1574 4 the the DT cord-023095-4dannjjm 1574 5 results result NNS cord-023095-4dannjjm 1574 6 of of IN cord-023095-4dannjjm 1574 7 serum serum NN cord-023095-4dannjjm 1574 8 biochemical biochemical JJ cord-023095-4dannjjm 1574 9 analysis analysis NN cord-023095-4dannjjm 1574 10 can can MD cord-023095-4dannjjm 1574 11 be be VB cord-023095-4dannjjm 1574 12 used use VBN cord-023095-4dannjjm 1574 13 for for IN cord-023095-4dannjjm 1574 14 acid acid NN cord-023095-4dannjjm 1574 15 - - HYPH cord-023095-4dannjjm 1574 16 base base NN cord-023095-4dannjjm 1574 17 interpretation interpretation NN cord-023095-4dannjjm 1574 18 in in IN cord-023095-4dannjjm 1574 19 horses horse NNS cord-023095-4dannjjm 1574 20 . . . cord-023095-4dannjjm 1575 1 The the DT cord-023095-4dannjjm 1575 2 objective objective NN cord-023095-4dannjjm 1575 3 was be VBD cord-023095-4dannjjm 1575 4 to to TO cord-023095-4dannjjm 1575 5 determine determine VB cord-023095-4dannjjm 1575 6 whether whether IN cord-023095-4dannjjm 1575 7 blood blood NN cord-023095-4dannjjm 1575 8 pH ph NN cord-023095-4dannjjm 1575 9 , , , cord-023095-4dannjjm 1575 10 anion anion NN cord-023095-4dannjjm 1575 11 gap gap NN cord-023095-4dannjjm 1575 12 , , , cord-023095-4dannjjm 1575 13 and and CC cord-023095-4dannjjm 1575 14 strong strong JJ cord-023095-4dannjjm 1575 15 ion ion NN cord-023095-4dannjjm 1575 16 gap gap NN cord-023095-4dannjjm 1575 17 could could MD cord-023095-4dannjjm 1575 18 be be VB cord-023095-4dannjjm 1575 19 quantitatively quantitatively RB cord-023095-4dannjjm 1575 20 estimated estimate VBN cord-023095-4dannjjm 1575 21 and and CC cord-023095-4dannjjm 1575 22 clinically clinically RB cord-023095-4dannjjm 1575 23 used use VBN cord-023095-4dannjjm 1575 24 based base VBN cord-023095-4dannjjm 1575 25 on on IN cord-023095-4dannjjm 1575 26 the the DT cord-023095-4dannjjm 1575 27 results result NNS cord-023095-4dannjjm 1575 28 of of IN cord-023095-4dannjjm 1575 29 serum serum NN cord-023095-4dannjjm 1575 30 or or CC cord-023095-4dannjjm 1575 31 plasma plasma NN cord-023095-4dannjjm 1575 32 biochemical biochemical JJ cord-023095-4dannjjm 1575 33 analysis analysis NN cord-023095-4dannjjm 1575 34 . . . cord-023095-4dannjjm 1576 1 100 100 CD cord-023095-4dannjjm 1576 2 horses horse NNS cord-023095-4dannjjm 1576 3 ( ( -LRB- cord-023095-4dannjjm 1576 4 70 70 CD cord-023095-4dannjjm 1576 5 adults adult NNS cord-023095-4dannjjm 1576 6 and and CC cord-023095-4dannjjm 1576 7 30 30 CD cord-023095-4dannjjm 1576 8 foals foal NNS cord-023095-4dannjjm 1576 9 ) ) -RRB- cord-023095-4dannjjm 1576 10 presented present VBD cord-023095-4dannjjm 1576 11 to to IN cord-023095-4dannjjm 1576 12 the the DT cord-023095-4dannjjm 1576 13 isolation isolation NN cord-023095-4dannjjm 1576 14 unit unit NN cord-023095-4dannjjm 1576 15 of of IN cord-023095-4dannjjm 1576 16 our -PRON- PRP$ cord-023095-4dannjjm 1576 17 Veterinary Veterinary NNP cord-023095-4dannjjm 1576 18 Teaching Teaching NNP cord-023095-4dannjjm 1576 19 Hospital Hospital NNP cord-023095-4dannjjm 1576 20 for for IN cord-023095-4dannjjm 1576 21 suspected suspect VBN cord-023095-4dannjjm 1576 22 infectious infectious JJ cord-023095-4dannjjm 1576 23 diseases disease NNS cord-023095-4dannjjm 1576 24 were be VBD cord-023095-4dannjjm 1576 25 prospectively prospectively RB cord-023095-4dannjjm 1576 26 enrolled enrol VBN cord-023095-4dannjjm 1576 27 . . . cord-023095-4dannjjm 1577 1 A a DT cord-023095-4dannjjm 1577 2 venous venous JJ cord-023095-4dannjjm 1577 3 serum serum NN cord-023095-4dannjjm 1577 4 sample sample NN cord-023095-4dannjjm 1577 5 was be VBD cord-023095-4dannjjm 1577 6 analyzed analyze VBN cord-023095-4dannjjm 1577 7 using use VBG cord-023095-4dannjjm 1577 8 a a DT cord-023095-4dannjjm 1577 9 Hitachi Hitachi NNP cord-023095-4dannjjm 1577 10 911 911 CD cord-023095-4dannjjm 1577 11 or or CC cord-023095-4dannjjm 1577 12 Copas Copas NNPS cord-023095-4dannjjm 1577 13 6000 6000 CD cord-023095-4dannjjm 1577 14 C501 c501 SYM cord-023095-4dannjjm 1577 15 automated automate VBN cord-023095-4dannjjm 1577 16 machine machine NN cord-023095-4dannjjm 1577 17 . . . cord-023095-4dannjjm 1578 1 Measured measured JJ cord-023095-4dannjjm 1578 2 parameters parameter NNS cord-023095-4dannjjm 1578 3 included include VBD cord-023095-4dannjjm 1578 4 strong strong JJ cord-023095-4dannjjm 1578 5 ion ion NN cord-023095-4dannjjm 1578 6 difference difference NN cord-023095-4dannjjm 1578 7 ( ( -LRB- cord-023095-4dannjjm 1578 8 SID SID NNP cord-023095-4dannjjm 1578 9 5 5 CD cord-023095-4dannjjm 1578 10 { { -LRB- cord-023095-4dannjjm 1578 11 Na1K}-{Cl1lac Na1K}-{Cl1lac NNP cord-023095-4dannjjm 1578 12 - - HYPH cord-023095-4dannjjm 1578 13 tate tate NNP cord-023095-4dannjjm 1578 14 } } -RRB- cord-023095-4dannjjm 1578 15 ) ) -RRB- cord-023095-4dannjjm 1578 16 , , , cord-023095-4dannjjm 1578 17 total total JJ cord-023095-4dannjjm 1578 18 protein protein NN cord-023095-4dannjjm 1578 19 concentration concentration NN cord-023095-4dannjjm 1578 20 ( ( -LRB- cord-023095-4dannjjm 1578 21 TP TP NNP cord-023095-4dannjjm 1578 22 ) ) -RRB- cord-023095-4dannjjm 1578 23 , , , cord-023095-4dannjjm 1578 24 and and CC cord-023095-4dannjjm 1578 25 total total JJ cord-023095-4dannjjm 1578 26 CO co NN cord-023095-4dannjjm 1578 27 2 2 CD cord-023095-4dannjjm 1578 28 ( ( -LRB- cord-023095-4dannjjm 1578 29 tCO tCO NNP cord-023095-4dannjjm 1578 30 2 2 CD cord-023095-4dannjjm 1578 31 ) ) -RRB- cord-023095-4dannjjm 1578 32 , , , cord-023095-4dannjjm 1578 33 with with IN cord-023095-4dannjjm 1578 34 lactate lactate NN cord-023095-4dannjjm 1578 35 being be VBG cord-023095-4dannjjm 1578 36 measured measure VBN cord-023095-4dannjjm 1578 37 by by IN cord-023095-4dannjjm 1578 38 blood blood NN cord-023095-4dannjjm 1578 39 gas gas NN cord-023095-4dannjjm 1578 40 analyzer analyzer NN cord-023095-4dannjjm 1578 41 . . . cord-023095-4dannjjm 1579 1 A a DT cord-023095-4dannjjm 1579 2 second second JJ cord-023095-4dannjjm 1579 3 venous venous JJ cord-023095-4dannjjm 1579 4 blood blood NN cord-023095-4dannjjm 1579 5 sample sample NN cord-023095-4dannjjm 1579 6 was be VBD cord-023095-4dannjjm 1579 7 collected collect VBN cord-023095-4dannjjm 1579 8 into into IN cord-023095-4dannjjm 1579 9 a a DT cord-023095-4dannjjm 1579 10 Na Na NNP cord-023095-4dannjjm 1579 11 - - HYPH cord-023095-4dannjjm 1579 12 heparin heparin JJ cord-023095-4dannjjm 1579 13 blood blood NN cord-023095-4dannjjm 1579 14 gas gas NN cord-023095-4dannjjm 1579 15 syringe syringe NN cord-023095-4dannjjm 1579 16 and and CC cord-023095-4dannjjm 1579 17 analyzed analyze VBD cord-023095-4dannjjm 1579 18 for for IN cord-023095-4dannjjm 1579 19 pH pH NNP cord-023095-4dannjjm 1579 20 ( ( -LRB- cord-023095-4dannjjm 1579 21 pH pH NNP cord-023095-4dannjjm 1579 22 m m NNP cord-023095-4dannjjm 1579 23 ) ) -RRB- cord-023095-4dannjjm 1579 24 , , , cord-023095-4dannjjm 1579 25 pCO pCO NNP cord-023095-4dannjjm 1579 26 2 2 CD cord-023095-4dannjjm 1579 27 and and CC cord-023095-4dannjjm 1579 28 concentrations concentration NNS cord-023095-4dannjjm 1579 29 of of IN cord-023095-4dannjjm 1579 30 Na Na NNP cord-023095-4dannjjm 1579 31 , , , cord-023095-4dannjjm 1579 32 K K NNP cord-023095-4dannjjm 1579 33 , , , cord-023095-4dannjjm 1579 34 Cl Cl NNP cord-023095-4dannjjm 1579 35 , , , cord-023095-4dannjjm 1579 36 and and CC cord-023095-4dannjjm 1579 37 lactate lactate NN cord-023095-4dannjjm 1579 38 using use VBG cord-023095-4dannjjm 1579 39 a a DT cord-023095-4dannjjm 1579 40 Radiometer Radiometer NNP cord-023095-4dannjjm 1579 41 800 800 CD cord-023095-4dannjjm 1579 42 Flex flex JJ cord-023095-4dannjjm 1579 43 blood blood NN cord-023095-4dannjjm 1579 44 gas gas NN cord-023095-4dannjjm 1579 45 analyzer analyzer NN cord-023095-4dannjjm 1579 46 ; ; : cord-023095-4dannjjm 1579 47 SID SID NNP cord-023095-4dannjjm 1579 48 was be VBD cord-023095-4dannjjm 1579 49 calculated calculate VBN cord-023095-4dannjjm 1579 50 from from IN cord-023095-4dannjjm 1579 51 the the DT cord-023095-4dannjjm 1579 52 measured measure VBN cord-023095-4dannjjm 1579 53 values value NNS cord-023095-4dannjjm 1579 54 , , , cord-023095-4dannjjm 1579 55 and and CC cord-023095-4dannjjm 1579 56 total total JJ cord-023095-4dannjjm 1579 57 solids solid NNS cord-023095-4dannjjm 1579 58 ( ( -LRB- cord-023095-4dannjjm 1579 59 TS TS NNP cord-023095-4dannjjm 1579 60 ) ) -RRB- cord-023095-4dannjjm 1579 61 were be VBD cord-023095-4dannjjm 1579 62 estimated estimate VBN cord-023095-4dannjjm 1579 63 using use VBG cord-023095-4dannjjm 1579 64 refractometry refractometry NNP cord-023095-4dannjjm 1579 65 . . . cord-023095-4dannjjm 1580 1 Serum/ serum/ NN cord-023095-4dannjjm 1580 2 plasma plasma NN cord-023095-4dannjjm 1580 3 pH ph NN cord-023095-4dannjjm 1581 1 ( ( -LRB- cord-023095-4dannjjm 1581 2 pH pH NNP cord-023095-4dannjjm 1581 3 calc calc NNP cord-023095-4dannjjm 1581 4 ) ) -RRB- cord-023095-4dannjjm 1581 5 was be VBD cord-023095-4dannjjm 1581 6 calculated calculate VBN cord-023095-4dannjjm 1581 7 using use VBG cord-023095-4dannjjm 1581 8 Stewart Stewart NNP cord-023095-4dannjjm 1581 9 's 's POS cord-023095-4dannjjm 1581 10 8 8 CD cord-023095-4dannjjm 1581 11 factor factor NN cord-023095-4dannjjm 1581 12 equation equation NN cord-023095-4dannjjm 1581 13 from from IN cord-023095-4dannjjm 1581 14 the the DT cord-023095-4dannjjm 1581 15 results result NNS cord-023095-4dannjjm 1581 16 of of IN cord-023095-4dannjjm 1581 17 serum serum NN cord-023095-4dannjjm 1581 18 or or CC cord-023095-4dannjjm 1581 19 plasma plasma NN cord-023095-4dannjjm 1581 20 biochemical biochemical JJ cord-023095-4dannjjm 1581 21 analysis analysis NN cord-023095-4dannjjm 1581 22 , , , cord-023095-4dannjjm 1581 23 assuming assume VBG cord-023095-4dannjjm 1581 24 pCO pCO NNP cord-023095-4dannjjm 1581 25 2 2 CD cord-023095-4dannjjm 1581 26 5 5 CD cord-023095-4dannjjm 1581 27 40 40 CD cord-023095-4dannjjm 1581 28 mmHg mmHg NNS cord-023095-4dannjjm 1581 29 for for IN cord-023095-4dannjjm 1581 30 serum serum NN cord-023095-4dannjjm 1581 31 and and CC cord-023095-4dannjjm 1581 32 pCO pco CD cord-023095-4dannjjm 1581 33 2 2 CD cord-023095-4dannjjm 1581 34 accurate accurate JJ cord-023095-4dannjjm 1581 35 for for IN cord-023095-4dannjjm 1581 36 plasma plasma NN cord-023095-4dannjjm 1581 37 . . . cord-023095-4dannjjm 1582 1 Anion anion NN cord-023095-4dannjjm 1582 2 gap gap NN cord-023095-4dannjjm 1582 3 ( ( -LRB- cord-023095-4dannjjm 1582 4 AG AG NNP cord-023095-4dannjjm 1582 5 ) ) -RRB- cord-023095-4dannjjm 1582 6 was be VBD cord-023095-4dannjjm 1582 7 calculated calculate VBN cord-023095-4dannjjm 1582 8 as as IN cord-023095-4dannjjm 1582 9 : : : cord-023095-4dannjjm 1582 10 AG AG NNP cord-023095-4dannjjm 1582 11 5 5 CD cord-023095-4dannjjm 1582 12 ( ( -LRB- cord-023095-4dannjjm 1582 13 Na1K)-(Cl1tCO Na1K)-(Cl1tCO NNP cord-023095-4dannjjm 1582 14 2 2 CD cord-023095-4dannjjm 1582 15 ) ) -RRB- cord-023095-4dannjjm 1582 16 . . . cord-023095-4dannjjm 1583 1 Strong strong JJ cord-023095-4dannjjm 1583 2 ion ion NN cord-023095-4dannjjm 1583 3 gap gap NN cord-023095-4dannjjm 1583 4 ( ( -LRB- cord-023095-4dannjjm 1583 5 SIG SIG NNP cord-023095-4dannjjm 1583 6 ) ) -RRB- cord-023095-4dannjjm 1583 7 was be VBD cord-023095-4dannjjm 1583 8 calculated calculate VBN cord-023095-4dannjjm 1583 9 as as IN cord-023095-4dannjjm 1583 10 : : : cord-023095-4dannjjm 1583 11 SIG SIG NNP cord-023095-4dannjjm 1583 12 5 5 CD cord-023095-4dannjjm 1583 13 0.21x[total 0.21x[total CD cord-023095-4dannjjm 1584 1 protein protein NN cord-023095-4dannjjm 1584 2 , , , cord-023095-4dannjjm 1584 3 g g NNP cord-023095-4dannjjm 1584 4 / / SYM cord-023095-4dannjjm 1584 5 L]/ L]/ NNP cord-023095-4dannjjm 1584 6 ( ( -LRB- cord-023095-4dannjjm 1584 7 1110 1110 CD cord-023095-4dannjjm 1584 8 { { -LRB- cord-023095-4dannjjm 1584 9 pKa pKa NNP cord-023095-4dannjjm 1584 10 - - HYPH cord-023095-4dannjjm 1584 11 pH pH NNP cord-023095-4dannjjm 1584 12 } } -RRB- cord-023095-4dannjjm 1584 13 ) ) -RRB- cord-023095-4dannjjm 1585 1 -AG -ag UH cord-023095-4dannjjm 1585 2 . . . cord-023095-4dannjjm 1586 1 Linear linear JJ cord-023095-4dannjjm 1586 2 regression regression NN cord-023095-4dannjjm 1586 3 analysis analysis NN cord-023095-4dannjjm 1586 4 was be VBD cord-023095-4dannjjm 1586 5 used use VBN cord-023095-4dannjjm 1586 6 to to TO cord-023095-4dannjjm 1586 7 compare compare VB cord-023095-4dannjjm 1586 8 pH pH NNP cord-023095-4dannjjm 1586 9 calc calc NNP cord-023095-4dannjjm 1586 10 to to IN cord-023095-4dannjjm 1586 11 pH pH NNP cord-023095-4dannjjm 1586 12 m m NNP cord-023095-4dannjjm 1586 13 , , , cord-023095-4dannjjm 1586 14 as as RB cord-023095-4dannjjm 1586 15 well well RB cord-023095-4dannjjm 1586 16 as as IN cord-023095-4dannjjm 1586 17 AG AG NNP cord-023095-4dannjjm 1586 18 and and CC cord-023095-4dannjjm 1586 19 SIG SIG NNP cord-023095-4dannjjm 1586 20 to to IN cord-023095-4dannjjm 1586 21 blood blood NN cord-023095-4dannjjm 1586 22 lactate lactate NN cord-023095-4dannjjm 1586 23 concentrations concentration NNS cord-023095-4dannjjm 1586 24 . . . cord-023095-4dannjjm 1587 1 Measured measure VBN cord-023095-4dannjjm 1587 2 pH pH NNP cord-023095-4dannjjm 1587 3 ranged range VBD cord-023095-4dannjjm 1587 4 from from IN cord-023095-4dannjjm 1587 5 7.03 7.03 CD cord-023095-4dannjjm 1587 6 to to IN cord-023095-4dannjjm 1587 7 7.48 7.48 CD cord-023095-4dannjjm 1587 8 ( ( -LRB- cord-023095-4dannjjm 1587 9 7.37 7.37 CD cord-023095-4dannjjm 1587 10 AE AE NNP cord-023095-4dannjjm 1587 11 0.07 0.07 CD cord-023095-4dannjjm 1587 12 ) ) -RRB- cord-023095-4dannjjm 1587 13 . . . cord-023095-4dannjjm 1588 1 Measured measure VBN cord-023095-4dannjjm 1588 2 SID SID NNP cord-023095-4dannjjm 1588 3 from from IN cord-023095-4dannjjm 1588 4 serum serum NN cord-023095-4dannjjm 1588 5 biochemistry biochemistry NN cord-023095-4dannjjm 1588 6 ( ( -LRB- cord-023095-4dannjjm 1588 7 SID SID NNP cord-023095-4dannjjm 1588 8 SB SB NNP cord-023095-4dannjjm 1588 9 ) ) -RRB- cord-023095-4dannjjm 1588 10 ranged range VBD cord-023095-4dannjjm 1588 11 from from IN cord-023095-4dannjjm 1588 12 22.3 22.3 CD cord-023095-4dannjjm 1588 13 to to IN cord-023095-4dannjjm 1588 14 51.4 51.4 CD cord-023095-4dannjjm 1588 15 mEq mEq NNS cord-023095-4dannjjm 1588 16 / / SYM cord-023095-4dannjjm 1588 17 L L NNP cord-023095-4dannjjm 1588 18 ( ( -LRB- cord-023095-4dannjjm 1588 19 36.2 36.2 CD cord-023095-4dannjjm 1588 20 AE AE NNP cord-023095-4dannjjm 1588 21 4.7 4.7 CD cord-023095-4dannjjm 1588 22 mEq mEq NNS cord-023095-4dannjjm 1588 23 / / SYM cord-023095-4dannjjm 1588 24 L L NNP cord-023095-4dannjjm 1588 25 ) ) -RRB- cord-023095-4dannjjm 1588 26 and and CC cord-023095-4dannjjm 1588 27 SID SID NNP cord-023095-4dannjjm 1588 28 from from IN cord-023095-4dannjjm 1588 29 blood blood NN cord-023095-4dannjjm 1588 30 gas gas NN cord-023095-4dannjjm 1588 31 analyzer analyzer NN cord-023095-4dannjjm 1588 32 ( ( -LRB- cord-023095-4dannjjm 1588 33 SID SID NNP cord-023095-4dannjjm 1588 34 BG BG NNP cord-023095-4dannjjm 1588 35 ) ) -RRB- cord-023095-4dannjjm 1588 36 from from IN cord-023095-4dannjjm 1588 37 14.3 14.3 CD cord-023095-4dannjjm 1588 38 to to IN cord-023095-4dannjjm 1588 39 46.6 46.6 CD cord-023095-4dannjjm 1588 40 mEq mEq NNS cord-023095-4dannjjm 1588 41 / / SYM cord-023095-4dannjjm 1588 42 L L NNP cord-023095-4dannjjm 1588 43 ( ( -LRB- cord-023095-4dannjjm 1588 44 33.3 33.3 CD cord-023095-4dannjjm 1588 45 AE AE NNP cord-023095-4dannjjm 1588 46 5.4 5.4 CD cord-023095-4dannjjm 1588 47 mEq mEq NNS cord-023095-4dannjjm 1588 48 / / SYM cord-023095-4dannjjm 1588 49 L l NN cord-023095-4dannjjm 1588 50 ; ; : cord-023095-4dannjjm 1588 51 R r NN cord-023095-4dannjjm 1588 52 2 2 CD cord-023095-4dannjjm 1588 53 5 5 CD cord-023095-4dannjjm 1588 54 0.59 0.59 CD cord-023095-4dannjjm 1588 55 ; ; : cord-023095-4dannjjm 1588 56 SID SID NNP cord-023095-4dannjjm 1588 57 BG BG NNP cord-023095-4dannjjm 1588 58 5 5 CD cord-023095-4dannjjm 1588 59 0.919 0.919 CD cord-023095-4dannjjm 1589 1 Â Â NNP cord-023095-4dannjjm 1589 2 SID SID NNP cord-023095-4dannjjm 1589 3 SB SB NNP cord-023095-4dannjjm 1589 4 ) ) -RRB- cord-023095-4dannjjm 1589 5 . . . cord-023095-4dannjjm 1590 1 SID SID NNP cord-023095-4dannjjm 1590 2 SB SB NNP cord-023095-4dannjjm 1590 3 and and CC cord-023095-4dannjjm 1590 4 SID SID NNP cord-023095-4dannjjm 1590 5 BG BG NNP cord-023095-4dannjjm 1590 6 showed show VBD cord-023095-4dannjjm 1590 7 small small JJ cord-023095-4dannjjm 1590 8 variability variability NN cord-023095-4dannjjm 1590 9 in in IN cord-023095-4dannjjm 1590 10 measurements measurement NNS cord-023095-4dannjjm 1590 11 . . . cord-023095-4dannjjm 1591 1 TP TP NNP cord-023095-4dannjjm 1591 2 ranged range VBD cord-023095-4dannjjm 1591 3 from from IN cord-023095-4dannjjm 1591 4 18 18 CD cord-023095-4dannjjm 1591 5 to to TO cord-023095-4dannjjm 1591 6 88 88 CD cord-023095-4dannjjm 1591 7 g g NN cord-023095-4dannjjm 1591 8 / / SYM cord-023095-4dannjjm 1591 9 L l NN cord-023095-4dannjjm 1591 10 ( ( -LRB- cord-023095-4dannjjm 1591 11 51.0 51.0 CD cord-023095-4dannjjm 1591 12 AE AE NNP cord-023095-4dannjjm 1591 13 13.9 13.9 CD cord-023095-4dannjjm 1591 14 g g NNP cord-023095-4dannjjm 1591 15 / / SYM cord-023095-4dannjjm 1591 16 L L NNP cord-023095-4dannjjm 1591 17 ) ) -RRB- cord-023095-4dannjjm 1591 18 and and CC cord-023095-4dannjjm 1591 19 TS TS NNP cord-023095-4dannjjm 1591 20 from from IN cord-023095-4dannjjm 1591 21 20 20 CD cord-023095-4dannjjm 1591 22 - - SYM cord-023095-4dannjjm 1591 23 84 84 CD cord-023095-4dannjjm 1591 24 ( ( -LRB- cord-023095-4dannjjm 1591 25 55.2 55.2 CD cord-023095-4dannjjm 1591 26 AE AE NNP cord-023095-4dannjjm 1591 27 13.8 13.8 CD cord-023095-4dannjjm 1591 28 g g NN cord-023095-4dannjjm 1591 29 / / SYM cord-023095-4dannjjm 1591 30 L l NN cord-023095-4dannjjm 1591 31 ; ; : cord-023095-4dannjjm 1591 32 R r NN cord-023095-4dannjjm 1591 33 2 2 CD cord-023095-4dannjjm 1591 34 5 5 CD cord-023095-4dannjjm 1591 35 0.77 0.77 CD cord-023095-4dannjjm 1591 36 ; ; : cord-023095-4dannjjm 1591 37 TS TS NNP cord-023095-4dannjjm 1591 38 5 5 CD cord-023095-4dannjjm 1591 39 1.071 1.071 CD cord-023095-4dannjjm 1591 40 Â â CD cord-023095-4dannjjm 1591 41 TP tp NN cord-023095-4dannjjm 1591 42 ) ) -RRB- cord-023095-4dannjjm 1591 43 . . . cord-023095-4dannjjm 1592 1 Using use VBG cord-023095-4dannjjm 1592 2 SID SID NNP cord-023095-4dannjjm 1592 3 SB SB NNP cord-023095-4dannjjm 1592 4 and and CC cord-023095-4dannjjm 1592 5 tCO tco NN cord-023095-4dannjjm 1592 6 2 2 CD cord-023095-4dannjjm 1592 7 values value NNS cord-023095-4dannjjm 1592 8 with with IN cord-023095-4dannjjm 1592 9 constant constant JJ cord-023095-4dannjjm 1592 10 pCO pco CD cord-023095-4dannjjm 1592 11 2 2 CD cord-023095-4dannjjm 1592 12 , , , cord-023095-4dannjjm 1592 13 pH pH NNP cord-023095-4dannjjm 1592 14 calc calc NNP cord-023095-4dannjjm 1592 15 was be VBD cord-023095-4dannjjm 1592 16 poorly poorly RB cord-023095-4dannjjm 1592 17 associated associate VBN cord-023095-4dannjjm 1592 18 with with IN cord-023095-4dannjjm 1592 19 pH pH NNP cord-023095-4dannjjm 1592 20 m m NNP cord-023095-4dannjjm 1592 21 ( ( -LRB- cord-023095-4dannjjm 1592 22 R r NN cord-023095-4dannjjm 1592 23 2 2 CD cord-023095-4dannjjm 1592 24 5 5 CD cord-023095-4dannjjm 1592 25 0.27 0.27 CD cord-023095-4dannjjm 1592 26 ; ; : cord-023095-4dannjjm 1592 27 pH pH NNP cord-023095-4dannjjm 1592 28 calc calc NNP cord-023095-4dannjjm 1592 29 5 5 CD cord-023095-4dannjjm 1592 30 0.48 0.48 CD cord-023095-4dannjjm 1592 31 1 1 CD cord-023095-4dannjjm 1592 32 3.89 3.89 CD cord-023095-4dannjjm 1592 33 ) ) -RRB- cord-023095-4dannjjm 1592 34 . . . cord-023095-4dannjjm 1593 1 In in IN cord-023095-4dannjjm 1593 2 contrast contrast NN cord-023095-4dannjjm 1593 3 , , , cord-023095-4dannjjm 1593 4 using use VBG cord-023095-4dannjjm 1593 5 SID SID NNP cord-023095-4dannjjm 1593 6 BG BG NNP cord-023095-4dannjjm 1593 7 with with IN cord-023095-4dannjjm 1593 8 accurate accurate JJ cord-023095-4dannjjm 1593 9 pCO pco CD cord-023095-4dannjjm 1593 10 2 2 CD cord-023095-4dannjjm 1593 11 , , , cord-023095-4dannjjm 1593 12 pH pH NNP cord-023095-4dannjjm 1593 13 calc calc NNP cord-023095-4dannjjm 1593 14 was be VBD cord-023095-4dannjjm 1593 15 closely closely RB cord-023095-4dannjjm 1593 16 associated associate VBN cord-023095-4dannjjm 1593 17 with with IN cord-023095-4dannjjm 1593 18 pH pH NNP cord-023095-4dannjjm 1593 19 m m NNP cord-023095-4dannjjm 1593 20 ( ( -LRB- cord-023095-4dannjjm 1593 21 R R NNP cord-023095-4dannjjm 1593 22 2 2 CD cord-023095-4dannjjm 1593 23 5 5 CD cord-023095-4dannjjm 1593 24 0.54 0.54 CD cord-023095-4dannjjm 1593 25 ; ; . cord-023095-4dannjjm 1594 1 pHcalc pHcalc NNP cord-023095-4dannjjm 1594 2 5 5 CD cord-023095-4dannjjm 1594 3 0.98 0.98 CD cord-023095-4dannjjm 1594 4 1 1 CD cord-023095-4dannjjm 1594 5 0.15 0.15 CD cord-023095-4dannjjm 1594 6 ) ) -RRB- cord-023095-4dannjjm 1594 7 and and CC cord-023095-4dannjjm 1594 8 the the DT cord-023095-4dannjjm 1594 9 equation equation NN cord-023095-4dannjjm 1594 10 was be VBD cord-023095-4dannjjm 1594 11 not not RB cord-023095-4dannjjm 1594 12 different different JJ cord-023095-4dannjjm 1594 13 from from IN cord-023095-4dannjjm 1594 14 the the DT cord-023095-4dannjjm 1594 15 line line NN cord-023095-4dannjjm 1594 16 of of IN cord-023095-4dannjjm 1594 17 identity identity NN cord-023095-4dannjjm 1594 18 . . . cord-023095-4dannjjm 1595 1 Anion anion NN cord-023095-4dannjjm 1595 2 gap gap NN cord-023095-4dannjjm 1595 3 and and CC cord-023095-4dannjjm 1595 4 SIG SIG NNP cord-023095-4dannjjm 1595 5 ( ( -LRB- cord-023095-4dannjjm 1595 6 mEq mEq NNS cord-023095-4dannjjm 1595 7 / / SYM cord-023095-4dannjjm 1595 8 L L NNP cord-023095-4dannjjm 1595 9 ) ) -RRB- cord-023095-4dannjjm 1595 10 calculated calculate VBN cord-023095-4dannjjm 1595 11 were be VBD cord-023095-4dannjjm 1595 12 significantly significantly RB cord-023095-4dannjjm 1595 13 linearly linearly RB cord-023095-4dannjjm 1595 14 correlated correlate VBN cord-023095-4dannjjm 1595 15 with with IN cord-023095-4dannjjm 1595 16 lactate lactate NN cord-023095-4dannjjm 1595 17 concentrations concentration NNS cord-023095-4dannjjm 1595 18 ( ( -LRB- cord-023095-4dannjjm 1595 19 mmol mmol NNP cord-023095-4dannjjm 1595 20 / / SYM cord-023095-4dannjjm 1595 21 L L NNP cord-023095-4dannjjm 1595 22 ) ) -RRB- cord-023095-4dannjjm 1595 23 ; ; : cord-023095-4dannjjm 1595 24 AG AG NNP cord-023095-4dannjjm 1595 25 5 5 CD cord-023095-4dannjjm 1595 26 0.93 0.93 CD cord-023095-4dannjjm 1595 27 Â â NN cord-023095-4dannjjm 1596 1 [ [ -LRB- cord-023095-4dannjjm 1596 2 lactate lactate NN cord-023095-4dannjjm 1596 3 ] ] -RRB- cord-023095-4dannjjm 1596 4 1 1 CD cord-023095-4dannjjm 1596 5 8.3 8.3 CD cord-023095-4dannjjm 1597 1 ( ( -LRB- cord-023095-4dannjjm 1597 2 R r NN cord-023095-4dannjjm 1597 3 2 2 CD cord-023095-4dannjjm 1597 4 5 5 CD cord-023095-4dannjjm 1597 5 0.39 0.39 CD cord-023095-4dannjjm 1597 6 ) ) -RRB- cord-023095-4dannjjm 1597 7 , , , cord-023095-4dannjjm 1597 8 and and CC cord-023095-4dannjjm 1597 9 SIG SIG NNP cord-023095-4dannjjm 1597 10 5 5 CD cord-023095-4dannjjm 1598 1 À0.91 À0.91 NNP cord-023095-4dannjjm 1599 1 Â â LS cord-023095-4dannjjm 1599 2 [ [ -LRB- cord-023095-4dannjjm 1599 3 lactate lactate NN cord-023095-4dannjjm 1599 4 ] ] -RRB- cord-023095-4dannjjm 1599 5 1 1 CD cord-023095-4dannjjm 1599 6 0.5 0.5 CD cord-023095-4dannjjm 1600 1 ( ( -LRB- cord-023095-4dannjjm 1600 2 R r NN cord-023095-4dannjjm 1600 3 2 2 CD cord-023095-4dannjjm 1600 4 5 5 CD cord-023095-4dannjjm 1600 5 0.41 0.41 CD cord-023095-4dannjjm 1600 6 ) ) -RRB- cord-023095-4dannjjm 1600 7 . . . cord-023095-4dannjjm 1601 1 We -PRON- PRP cord-023095-4dannjjm 1601 2 conclude conclude VBP cord-023095-4dannjjm 1601 3 that that IN cord-023095-4dannjjm 1601 4 pH pH NNP cord-023095-4dannjjm 1601 5 calc calc NNP cord-023095-4dannjjm 1601 6 using use VBG cord-023095-4dannjjm 1601 7 SID SID NNP cord-023095-4dannjjm 1601 8 SB SB NNP cord-023095-4dannjjm 1601 9 , , , cord-023095-4dannjjm 1601 10 tCO tco NN cord-023095-4dannjjm 1601 11 2 2 CD cord-023095-4dannjjm 1601 12 and and CC cord-023095-4dannjjm 1601 13 constant constant JJ cord-023095-4dannjjm 1601 14 pCO pCO VBN cord-023095-4dannjjm 1601 15 2 2 CD cord-023095-4dannjjm 1601 16 values value NNS cord-023095-4dannjjm 1601 17 is be VBZ cord-023095-4dannjjm 1601 18 not not RB cord-023095-4dannjjm 1601 19 accurate accurate JJ cord-023095-4dannjjm 1601 20 . . . cord-023095-4dannjjm 1602 1 However however RB cord-023095-4dannjjm 1602 2 , , , cord-023095-4dannjjm 1602 3 variability variability NN cord-023095-4dannjjm 1602 4 of of IN cord-023095-4dannjjm 1602 5 measured measure VBN cord-023095-4dannjjm 1602 6 biochemical biochemical JJ cord-023095-4dannjjm 1602 7 parameters parameter NNS cord-023095-4dannjjm 1602 8 between between IN cord-023095-4dannjjm 1602 9 machines machine NNS cord-023095-4dannjjm 1602 10 was be VBD cord-023095-4dannjjm 1602 11 small small JJ cord-023095-4dannjjm 1602 12 , , , cord-023095-4dannjjm 1602 13 permitting permit VBG cord-023095-4dannjjm 1602 14 use use NN cord-023095-4dannjjm 1602 15 of of IN cord-023095-4dannjjm 1602 16 serum serum NN cord-023095-4dannjjm 1602 17 biochemistry biochemistry NN cord-023095-4dannjjm 1602 18 for for IN cord-023095-4dannjjm 1602 19 clinical clinical JJ cord-023095-4dannjjm 1602 20 metabolic metabolic JJ cord-023095-4dannjjm 1602 21 acid acid NN cord-023095-4dannjjm 1602 22 - - HYPH cord-023095-4dannjjm 1602 23 base base NN cord-023095-4dannjjm 1602 24 abnormalities abnormality NNS cord-023095-4dannjjm 1602 25 interpretations interpretation NNS cord-023095-4dannjjm 1602 26 of of IN cord-023095-4dannjjm 1602 27 patients patient NNS cord-023095-4dannjjm 1602 28 . . . cord-023095-4dannjjm 1603 1 These these DT cord-023095-4dannjjm 1603 2 results result NNS cord-023095-4dannjjm 1603 3 reemphasize reemphasize VBP cord-023095-4dannjjm 1603 4 the the DT cord-023095-4dannjjm 1603 5 importance importance NN cord-023095-4dannjjm 1603 6 of of IN cord-023095-4dannjjm 1603 7 strong strong JJ cord-023095-4dannjjm 1603 8 electrolytes electrolyte NNS cord-023095-4dannjjm 1603 9 and and CC cord-023095-4dannjjm 1603 10 proteins protein NNS cord-023095-4dannjjm 1603 11 in in IN cord-023095-4dannjjm 1603 12 acid acid NN cord-023095-4dannjjm 1603 13 - - HYPH cord-023095-4dannjjm 1603 14 base base NN cord-023095-4dannjjm 1603 15 balance balance NN cord-023095-4dannjjm 1603 16 . . . cord-023095-4dannjjm 1604 1 Metalloproteinases Metalloproteinases NNP cord-023095-4dannjjm 1604 2 ( ( -LRB- cord-023095-4dannjjm 1604 3 MMPs MMPs NNP cord-023095-4dannjjm 1604 4 ) ) -RRB- cord-023095-4dannjjm 1604 5 are be VBP cord-023095-4dannjjm 1604 6 critically critically RB cord-023095-4dannjjm 1604 7 important important JJ cord-023095-4dannjjm 1604 8 in in IN cord-023095-4dannjjm 1604 9 remodeling remodel VBG cord-023095-4dannjjm 1604 10 processes process NNS cord-023095-4dannjjm 1604 11 and and CC cord-023095-4dannjjm 1604 12 in in IN cord-023095-4dannjjm 1604 13 wound wound JJ cord-023095-4dannjjm 1604 14 healing healing NN cord-023095-4dannjjm 1604 15 . . . cord-023095-4dannjjm 1605 1 However however RB cord-023095-4dannjjm 1605 2 , , , cord-023095-4dannjjm 1605 3 excessive excessive JJ cord-023095-4dannjjm 1605 4 activation activation NN cord-023095-4dannjjm 1605 5 of of IN cord-023095-4dannjjm 1605 6 MMPs mmp NNS cord-023095-4dannjjm 1605 7 by by IN cord-023095-4dannjjm 1605 8 pro pro JJ cord-023095-4dannjjm 1605 9 - - JJ cord-023095-4dannjjm 1605 10 inflammatory inflammatory JJ cord-023095-4dannjjm 1605 11 mediators mediator NNS cord-023095-4dannjjm 1605 12 including include VBG cord-023095-4dannjjm 1605 13 cytokines cytokine NNS cord-023095-4dannjjm 1605 14 , , , cord-023095-4dannjjm 1605 15 prostaglandin prostaglandin NN cord-023095-4dannjjm 1605 16 E2 e2 NN cord-023095-4dannjjm 1605 17 , , , cord-023095-4dannjjm 1605 18 and and CC cord-023095-4dannjjm 1605 19 nitric nitric NN cord-023095-4dannjjm 1605 20 oxide oxide NN cord-023095-4dannjjm 1605 21 lead lead NN cord-023095-4dannjjm 1605 22 to to IN cord-023095-4dannjjm 1605 23 tissue tissue NN cord-023095-4dannjjm 1605 24 breakdown breakdown NN cord-023095-4dannjjm 1605 25 . . . cord-023095-4dannjjm 1606 1 This this DT cord-023095-4dannjjm 1606 2 is be VBZ cord-023095-4dannjjm 1606 3 observed observe VBN cord-023095-4dannjjm 1606 4 in in IN cord-023095-4dannjjm 1606 5 osteoarthritis osteoarthritis NN cord-023095-4dannjjm 1606 6 ( ( -LRB- cord-023095-4dannjjm 1606 7 OA OA NNP cord-023095-4dannjjm 1606 8 ) ) -RRB- cord-023095-4dannjjm 1606 9 which which WDT cord-023095-4dannjjm 1606 10 is be VBZ cord-023095-4dannjjm 1606 11 characterized characterize VBN cord-023095-4dannjjm 1606 12 by by IN cord-023095-4dannjjm 1606 13 erosive erosive JJ cord-023095-4dannjjm 1606 14 lesions lesion NNS cord-023095-4dannjjm 1606 15 in in IN cord-023095-4dannjjm 1606 16 articular articular JJ cord-023095-4dannjjm 1606 17 cartilage cartilage NN cord-023095-4dannjjm 1606 18 . . . cord-023095-4dannjjm 1607 1 In in IN cord-023095-4dannjjm 1607 2 Hereditary Hereditary NNP cord-023095-4dannjjm 1607 3 Equine Equine NNP cord-023095-4dannjjm 1607 4 Regional Regional NNP cord-023095-4dannjjm 1607 5 Dermal Dermal NNP cord-023095-4dannjjm 1607 6 Asthenia Asthenia NNP cord-023095-4dannjjm 1607 7 ( ( -LRB- cord-023095-4dannjjm 1607 8 HERDA HERDA NNP cord-023095-4dannjjm 1607 9 ) ) -RRB- cord-023095-4dannjjm 1607 10 , , , cord-023095-4dannjjm 1607 11 afflicted afflict VBN cord-023095-4dannjjm 1607 12 horses horse NNS cord-023095-4dannjjm 1607 13 exhibit exhibit VBP cord-023095-4dannjjm 1607 14 collagen collagen NN cord-023095-4dannjjm 1607 15 abnormalities abnormality NNS cord-023095-4dannjjm 1607 16 and and CC cord-023095-4dannjjm 1607 17 can can MD cord-023095-4dannjjm 1607 18 have have VB cord-023095-4dannjjm 1607 19 associated associate VBN cord-023095-4dannjjm 1607 20 chronic chronic JJ cord-023095-4dannjjm 1607 21 inflammation inflammation NN cord-023095-4dannjjm 1607 22 and and CC cord-023095-4dannjjm 1607 23 aberrant aberrant JJ cord-023095-4dannjjm 1607 24 wound wound NN cord-023095-4dannjjm 1607 25 repair repair NN cord-023095-4dannjjm 1607 26 . . . cord-023095-4dannjjm 1608 1 HERDA HERDA NNP cord-023095-4dannjjm 1608 2 affects affect VBZ cord-023095-4dannjjm 1608 3 horses horse NNS cord-023095-4dannjjm 1608 4 with with IN cord-023095-4dannjjm 1608 5 Quarter Quarter NNP cord-023095-4dannjjm 1608 6 Horse Horse NNP cord-023095-4dannjjm 1608 7 bloodlines bloodline NNS cord-023095-4dannjjm 1608 8 and and CC cord-023095-4dannjjm 1608 9 is be VBZ cord-023095-4dannjjm 1608 10 similar similar JJ cord-023095-4dannjjm 1608 11 to to IN cord-023095-4dannjjm 1608 12 the the DT cord-023095-4dannjjm 1608 13 human human JJ cord-023095-4dannjjm 1608 14 hereditary hereditary JJ cord-023095-4dannjjm 1608 15 connective connective JJ cord-023095-4dannjjm 1608 16 tissue tissue NN cord-023095-4dannjjm 1608 17 syndrome syndrome NN cord-023095-4dannjjm 1608 18 Ehlers Ehlers NNP cord-023095-4dannjjm 1608 19 Danlos Danlos NNP cord-023095-4dannjjm 1608 20 ( ( -LRB- cord-023095-4dannjjm 1608 21 EDS EDS NNP cord-023095-4dannjjm 1608 22 ) ) -RRB- cord-023095-4dannjjm 1608 23 . . . cord-023095-4dannjjm 1609 1 Many many JJ cord-023095-4dannjjm 1609 2 adult adult NN cord-023095-4dannjjm 1609 3 EDS EDS NNP cord-023095-4dannjjm 1609 4 patients patient NNS cord-023095-4dannjjm 1609 5 suffer suffer VBP cord-023095-4dannjjm 1609 6 from from IN cord-023095-4dannjjm 1609 7 joint joint JJ cord-023095-4dannjjm 1609 8 pain pain NN cord-023095-4dannjjm 1609 9 and and CC cord-023095-4dannjjm 1609 10 OA OA NNP cord-023095-4dannjjm 1609 11 . . . cord-023095-4dannjjm 1610 1 We -PRON- PRP cord-023095-4dannjjm 1610 2 hypothesized hypothesize VBD cord-023095-4dannjjm 1610 3 that that IN cord-023095-4dannjjm 1610 4 chondrocytes chondrocyte NNS cord-023095-4dannjjm 1610 5 from from IN cord-023095-4dannjjm 1610 6 articular articular JJ cord-023095-4dannjjm 1610 7 cartilage cartilage NN cord-023095-4dannjjm 1610 8 of of IN cord-023095-4dannjjm 1610 9 HERDA HERDA NNP cord-023095-4dannjjm 1610 10 horses horse NNS cord-023095-4dannjjm 1610 11 have have VBP cord-023095-4dannjjm 1610 12 increased increase VBN cord-023095-4dannjjm 1610 13 activity activity NN cord-023095-4dannjjm 1610 14 of of IN cord-023095-4dannjjm 1610 15 MMPs mmp NNS cord-023095-4dannjjm 1610 16 . . . cord-023095-4dannjjm 1611 1 To to TO cord-023095-4dannjjm 1611 2 test test VB cord-023095-4dannjjm 1611 3 this this DT cord-023095-4dannjjm 1611 4 hypothesis hypothesis NN cord-023095-4dannjjm 1611 5 , , , cord-023095-4dannjjm 1611 6 chondrocytes chondrocyte NNS cord-023095-4dannjjm 1611 7 were be VBD cord-023095-4dannjjm 1611 8 retrieved retrieve VBN cord-023095-4dannjjm 1611 9 from from IN cord-023095-4dannjjm 1611 10 articular articular JJ cord-023095-4dannjjm 1611 11 cartilage cartilage NN cord-023095-4dannjjm 1611 12 of of IN cord-023095-4dannjjm 1611 13 homozygous homozygous JJ cord-023095-4dannjjm 1611 14 HERDA HERDA NNP cord-023095-4dannjjm 1611 15 carpal carpal NN cord-023095-4dannjjm 1611 16 and and CC cord-023095-4dannjjm 1611 17 hock hock NN cord-023095-4dannjjm 1611 18 joints joint NNS cord-023095-4dannjjm 1611 19 . . . cord-023095-4dannjjm 1612 1 Chondrocytes chondrocyte NNS cord-023095-4dannjjm 1612 2 from from IN cord-023095-4dannjjm 1612 3 normal normal JJ cord-023095-4dannjjm 1612 4 horses horse NNS cord-023095-4dannjjm 1612 5 were be VBD cord-023095-4dannjjm 1612 6 also also RB cord-023095-4dannjjm 1612 7 obtained obtain VBN cord-023095-4dannjjm 1612 8 for for IN cord-023095-4dannjjm 1612 9 comparison comparison NN cord-023095-4dannjjm 1612 10 . . . cord-023095-4dannjjm 1613 1 Chondrocytes Chondrocytes NNP cord-023095-4dannjjm 1613 2 were be VBD cord-023095-4dannjjm 1613 3 seeded seed VBN cord-023095-4dannjjm 1613 4 at at IN cord-023095-4dannjjm 1613 5 5 5 CD cord-023095-4dannjjm 1613 6 x x SYM cord-023095-4dannjjm 1613 7 10 10 CD cord-023095-4dannjjm 1613 8 6 6 CD cord-023095-4dannjjm 1613 9 /ml /ml . cord-023095-4dannjjm 1613 10 into into IN cord-023095-4dannjjm 1613 11 6-well 6-well CD cord-023095-4dannjjm 1613 12 plates plate NNS cord-023095-4dannjjm 1613 13 and and CC cord-023095-4dannjjm 1613 14 incubated incubate VBN cord-023095-4dannjjm 1613 15 at at IN cord-023095-4dannjjm 1613 16 371C 371c CD cord-023095-4dannjjm 1613 17 , , , cord-023095-4dannjjm 1613 18 5 5 CD cord-023095-4dannjjm 1613 19 % % NN cord-023095-4dannjjm 1613 20 CO co NN cord-023095-4dannjjm 1613 21 2 2 CD cord-023095-4dannjjm 1613 22 for for IN cord-023095-4dannjjm 1613 23 up up IN cord-023095-4dannjjm 1613 24 to to TO cord-023095-4dannjjm 1613 25 seven seven CD cord-023095-4dannjjm 1613 26 days day NNS cord-023095-4dannjjm 1613 27 . . . cord-023095-4dannjjm 1614 1 Activity activity NN cord-023095-4dannjjm 1614 2 of of IN cord-023095-4dannjjm 1614 3 secreted secrete VBN cord-023095-4dannjjm 1614 4 MMPs mmp NNS cord-023095-4dannjjm 1614 5 was be VBD cord-023095-4dannjjm 1614 6 determined determine VBN cord-023095-4dannjjm 1614 7 by by IN cord-023095-4dannjjm 1614 8 zymography zymography NNP cord-023095-4dannjjm 1614 9 using use VBG cord-023095-4dannjjm 1614 10 equal equal JJ cord-023095-4dannjjm 1614 11 amounts amount NNS cord-023095-4dannjjm 1614 12 of of IN cord-023095-4dannjjm 1614 13 proteins protein NNS cord-023095-4dannjjm 1614 14 for for IN cord-023095-4dannjjm 1614 15 loading loading NN cord-023095-4dannjjm 1614 16 . . . cord-023095-4dannjjm 1615 1 Secreted secreted JJ cord-023095-4dannjjm 1615 2 MMPs mmp NNS cord-023095-4dannjjm 1615 3 were be VBD cord-023095-4dannjjm 1615 4 analyzed analyze VBN cord-023095-4dannjjm 1615 5 by by IN cord-023095-4dannjjm 1615 6 Western western JJ cord-023095-4dannjjm 1615 7 blot blot NN cord-023095-4dannjjm 1615 8 . . . cord-023095-4dannjjm 1616 1 Zymography Zymography NNP cord-023095-4dannjjm 1616 2 showed show VBD cord-023095-4dannjjm 1616 3 that that IN cord-023095-4dannjjm 1616 4 normal normal JJ cord-023095-4dannjjm 1616 5 chondrocytes chondrocyte NNS cord-023095-4dannjjm 1616 6 secreted secrete VBD cord-023095-4dannjjm 1616 7 two two CD cord-023095-4dannjjm 1616 8 major major JJ cord-023095-4dannjjm 1616 9 bands band NNS cord-023095-4dannjjm 1616 10 with with IN cord-023095-4dannjjm 1616 11 gelatinolytic gelatinolytic JJ cord-023095-4dannjjm 1616 12 activity activity NN cord-023095-4dannjjm 1616 13 observed observe VBN cord-023095-4dannjjm 1616 14 at at IN cord-023095-4dannjjm 1616 15 92 92 CD cord-023095-4dannjjm 1616 16 and and CC cord-023095-4dannjjm 1616 17 72 72 CD cord-023095-4dannjjm 1616 18 kDa kDa NNS cord-023095-4dannjjm 1616 19 suggestive suggestive JJ cord-023095-4dannjjm 1616 20 of of IN cord-023095-4dannjjm 1616 21 the the DT cord-023095-4dannjjm 1616 22 latent latent JJ cord-023095-4dannjjm 1616 23 form form NN cord-023095-4dannjjm 1616 24 of of IN cord-023095-4dannjjm 1616 25 MMP-2 MMP-2 NNP cord-023095-4dannjjm 1616 26 and and CC cord-023095-4dannjjm 1616 27 MMP-9 MMP-9 NNP cord-023095-4dannjjm 1616 28 , , , cord-023095-4dannjjm 1616 29 respectively respectively RB cord-023095-4dannjjm 1616 30 . . . cord-023095-4dannjjm 1617 1 Less less RBR cord-023095-4dannjjm 1617 2 intense intense JJ cord-023095-4dannjjm 1617 3 bands band NNS cord-023095-4dannjjm 1617 4 of of IN cord-023095-4dannjjm 1617 5 gelatinolytic gelatinolytic JJ cord-023095-4dannjjm 1617 6 activity activity NN cord-023095-4dannjjm 1617 7 were be VBD cord-023095-4dannjjm 1617 8 observed observe VBN cord-023095-4dannjjm 1617 9 at at IN cord-023095-4dannjjm 1617 10 about about RB cord-023095-4dannjjm 1617 11 82 82 CD cord-023095-4dannjjm 1617 12 and and CC cord-023095-4dannjjm 1617 13 62 62 CD cord-023095-4dannjjm 1617 14 kDa kDa NNS cord-023095-4dannjjm 1617 15 suggestive suggestive JJ cord-023095-4dannjjm 1617 16 of of IN cord-023095-4dannjjm 1617 17 the the DT cord-023095-4dannjjm 1617 18 active active JJ cord-023095-4dannjjm 1617 19 form form NN cord-023095-4dannjjm 1617 20 of of IN cord-023095-4dannjjm 1617 21 MMP-2 MMP-2 NNP cord-023095-4dannjjm 1617 22 and and CC cord-023095-4dannjjm 1617 23 MMP-9 MMP-9 NNP cord-023095-4dannjjm 1617 24 . . . cord-023095-4dannjjm 1618 1 Another another DT cord-023095-4dannjjm 1618 2 band band NN cord-023095-4dannjjm 1618 3 of of IN cord-023095-4dannjjm 1618 4 activity activity NN cord-023095-4dannjjm 1618 5 was be VBD cord-023095-4dannjjm 1618 6 also also RB cord-023095-4dannjjm 1618 7 seen see VBN cord-023095-4dannjjm 1618 8 at at IN cord-023095-4dannjjm 1618 9 240 240 CD cord-023095-4dannjjm 1618 10 kDa kDa NNS cord-023095-4dannjjm 1618 11 which which WDT cord-023095-4dannjjm 1618 12 is be VBZ cord-023095-4dannjjm 1618 13 suggestive suggestive JJ cord-023095-4dannjjm 1618 14 of of IN cord-023095-4dannjjm 1618 15 a a DT cord-023095-4dannjjm 1618 16 dimer dimer NN cord-023095-4dannjjm 1618 17 of of IN cord-023095-4dannjjm 1618 18 MMP-9 MMP-9 NNP cord-023095-4dannjjm 1618 19 that that WDT cord-023095-4dannjjm 1618 20 has have VBZ cord-023095-4dannjjm 1618 21 been be VBN cord-023095-4dannjjm 1618 22 reported report VBN cord-023095-4dannjjm 1618 23 when when WRB cord-023095-4dannjjm 1618 24 MMPs mmp NNS cord-023095-4dannjjm 1618 25 are be VBP cord-023095-4dannjjm 1618 26 in in IN cord-023095-4dannjjm 1618 27 excess excess NN cord-023095-4dannjjm 1618 28 of of IN cord-023095-4dannjjm 1618 29 tissue tissue NN cord-023095-4dannjjm 1618 30 inhibitors inhibitor NNS cord-023095-4dannjjm 1618 31 of of IN cord-023095-4dannjjm 1618 32 metalloproteinases metalloproteinase NNS cord-023095-4dannjjm 1618 33 ( ( -LRB- cord-023095-4dannjjm 1618 34 TIMPs TIMPs NNP cord-023095-4dannjjm 1618 35 ) ) -RRB- cord-023095-4dannjjm 1618 36 . . . cord-023095-4dannjjm 1619 1 Chondrocyte Chondrocyte NNP cord-023095-4dannjjm 1619 2 cultures culture NNS cord-023095-4dannjjm 1619 3 from from IN cord-023095-4dannjjm 1619 4 homozygous homozygous JJ cord-023095-4dannjjm 1619 5 HERDA HERDA NNP cord-023095-4dannjjm 1619 6 cartilage cartilage NN cord-023095-4dannjjm 1619 7 showed show VBD cord-023095-4dannjjm 1619 8 a a DT cord-023095-4dannjjm 1619 9 similar similar JJ cord-023095-4dannjjm 1619 10 profile profile NN cord-023095-4dannjjm 1619 11 but but CC cord-023095-4dannjjm 1619 12 with with IN cord-023095-4dannjjm 1619 13 decreased decrease VBN cord-023095-4dannjjm 1619 14 activity activity NN cord-023095-4dannjjm 1619 15 by by IN cord-023095-4dannjjm 1619 16 90 90 CD cord-023095-4dannjjm 1619 17 % % NN cord-023095-4dannjjm 1619 18 at at IN cord-023095-4dannjjm 1619 19 92 92 CD cord-023095-4dannjjm 1619 20 kDa kDa NNS cord-023095-4dannjjm 1619 21 and and CC cord-023095-4dannjjm 1619 22 10 10 CD cord-023095-4dannjjm 1619 23 - - SYM cord-023095-4dannjjm 1619 24 50 50 CD cord-023095-4dannjjm 1619 25 % % NN cord-023095-4dannjjm 1619 26 increased increase VBN cord-023095-4dannjjm 1619 27 activity activity NN cord-023095-4dannjjm 1619 28 at at IN cord-023095-4dannjjm 1619 29 72 72 CD cord-023095-4dannjjm 1619 30 kDA kda XX cord-023095-4dannjjm 1619 31 compared compare VBN cord-023095-4dannjjm 1619 32 to to IN cord-023095-4dannjjm 1619 33 normal normal JJ cord-023095-4dannjjm 1619 34 chondrocytes chondrocyte NNS cord-023095-4dannjjm 1619 35 . . . cord-023095-4dannjjm 1620 1 Western western JJ cord-023095-4dannjjm 1620 2 blot blot NN cord-023095-4dannjjm 1620 3 analysis analysis NN cord-023095-4dannjjm 1620 4 detected detect VBD cord-023095-4dannjjm 1620 5 MMP-2 MMP-2 NNP cord-023095-4dannjjm 1620 6 and and CC cord-023095-4dannjjm 1620 7 MMP-9 MMP-9 NNP cord-023095-4dannjjm 1620 8 immunoreactivity immunoreactivity NN cord-023095-4dannjjm 1620 9 in in IN cord-023095-4dannjjm 1620 10 chondrocyte chondrocyte NN cord-023095-4dannjjm 1620 11 culture culture NN cord-023095-4dannjjm 1620 12 media medium NNS cord-023095-4dannjjm 1620 13 of of IN cord-023095-4dannjjm 1620 14 HERDA HERDA NNP cord-023095-4dannjjm 1620 15 - - HYPH cord-023095-4dannjjm 1620 16 afflicted afflict VBN cord-023095-4dannjjm 1620 17 and and CC cord-023095-4dannjjm 1620 18 normal normal JJ cord-023095-4dannjjm 1620 19 horses horse NNS cord-023095-4dannjjm 1620 20 . . . cord-023095-4dannjjm 1621 1 The the DT cord-023095-4dannjjm 1621 2 present present JJ cord-023095-4dannjjm 1621 3 study study NN cord-023095-4dannjjm 1621 4 demonstrates demonstrate VBZ cord-023095-4dannjjm 1621 5 for for IN cord-023095-4dannjjm 1621 6 the the DT cord-023095-4dannjjm 1621 7 first first JJ cord-023095-4dannjjm 1621 8 time time NN cord-023095-4dannjjm 1621 9 that that WDT cord-023095-4dannjjm 1621 10 horses horse NNS cord-023095-4dannjjm 1621 11 suffering suffer VBG cord-023095-4dannjjm 1621 12 from from IN cord-023095-4dannjjm 1621 13 HERDA HERDA NNP cord-023095-4dannjjm 1621 14 have have VBP cord-023095-4dannjjm 1621 15 increased increase VBN cord-023095-4dannjjm 1621 16 MMP MMP NNP cord-023095-4dannjjm 1621 17 activity activity NN cord-023095-4dannjjm 1621 18 which which WDT cord-023095-4dannjjm 1621 19 may may MD cord-023095-4dannjjm 1621 20 predispose predispose VB cord-023095-4dannjjm 1621 21 them -PRON- PRP cord-023095-4dannjjm 1621 22 to to IN cord-023095-4dannjjm 1621 23 the the DT cord-023095-4dannjjm 1621 24 development development NN cord-023095-4dannjjm 1621 25 of of IN cord-023095-4dannjjm 1621 26 lesions lesion NNS cord-023095-4dannjjm 1621 27 in in IN cord-023095-4dannjjm 1621 28 articular articular JJ cord-023095-4dannjjm 1621 29 cartilage cartilage NN cord-023095-4dannjjm 1621 30 . . . cord-023095-4dannjjm 1622 1 Research research NN cord-023095-4dannjjm 1622 2 supported support VBN cord-023095-4dannjjm 1622 3 by by IN cord-023095-4dannjjm 1622 4 Nutramax Nutramax NNP cord-023095-4dannjjm 1622 5 Laboratories Laboratories NNP cord-023095-4dannjjm 1622 6 , , , cord-023095-4dannjjm 1623 1 Inc. Inc. NNP cord-023095-4dannjjm 1623 2 Equine Equine NNP cord-023095-4dannjjm 1623 3 Polysaccharide Polysaccharide NNP cord-023095-4dannjjm 1623 4 Storage Storage NNP cord-023095-4dannjjm 1623 5 Myopathy Myopathy NNP cord-023095-4dannjjm 1623 6 ( ( -LRB- cord-023095-4dannjjm 1623 7 PSSM PSSM NNP cord-023095-4dannjjm 1623 8 ) ) -RRB- cord-023095-4dannjjm 1623 9 type type NN cord-023095-4dannjjm 1623 10 1 1 CD cord-023095-4dannjjm 1623 11 is be VBZ cord-023095-4dannjjm 1623 12 a a DT cord-023095-4dannjjm 1623 13 dominantly dominantly RB cord-023095-4dannjjm 1623 14 inherited inherit VBN cord-023095-4dannjjm 1623 15 glycogenosis glycogenosis NN cord-023095-4dannjjm 1623 16 caused cause VBN cord-023095-4dannjjm 1623 17 by by IN cord-023095-4dannjjm 1623 18 a a DT cord-023095-4dannjjm 1623 19 mutation mutation NN cord-023095-4dannjjm 1623 20 in in IN cord-023095-4dannjjm 1623 21 the the DT cord-023095-4dannjjm 1623 22 gene gene NN cord-023095-4dannjjm 1623 23 coding code VBG cord-023095-4dannjjm 1623 24 for for IN cord-023095-4dannjjm 1623 25 skeletal skeletal JJ cord-023095-4dannjjm 1623 26 muscle muscle NN cord-023095-4dannjjm 1623 27 glycogen glycogen NN cord-023095-4dannjjm 1623 28 synthase synthase NN cord-023095-4dannjjm 1623 29 type type NN cord-023095-4dannjjm 1623 30 1 1 CD cord-023095-4dannjjm 1623 31 ( ( -LRB- cord-023095-4dannjjm 1623 32 GYS-1 GYS-1 NNP cord-023095-4dannjjm 1623 33 ) ) -RRB- cord-023095-4dannjjm 1623 34 . . . cord-023095-4dannjjm 1624 1 The the DT cord-023095-4dannjjm 1624 2 disease disease NN cord-023095-4dannjjm 1624 3 has have VBZ cord-023095-4dannjjm 1624 4 been be VBN cord-023095-4dannjjm 1624 5 reported report VBN cord-023095-4dannjjm 1624 6 to to TO cord-023095-4dannjjm 1624 7 affect affect VB cord-023095-4dannjjm 1624 8 the the DT cord-023095-4dannjjm 1624 9 Haflinger Haflinger NNP cord-023095-4dannjjm 1624 10 breed breed NN cord-023095-4dannjjm 1625 1 but but CC cord-023095-4dannjjm 1625 2 so so RB cord-023095-4dannjjm 1625 3 far far RB cord-023095-4dannjjm 1625 4 its -PRON- PRP$ cord-023095-4dannjjm 1625 5 prevalence prevalence NN cord-023095-4dannjjm 1625 6 is be VBZ cord-023095-4dannjjm 1625 7 unknown unknown JJ cord-023095-4dannjjm 1625 8 . . . cord-023095-4dannjjm 1626 1 Aim aim VB cord-023095-4dannjjm 1626 2 of of IN cord-023095-4dannjjm 1626 3 this this DT cord-023095-4dannjjm 1626 4 preliminary preliminary JJ cord-023095-4dannjjm 1626 5 study study NN cord-023095-4dannjjm 1626 6 was be VBD cord-023095-4dannjjm 1626 7 to to TO cord-023095-4dannjjm 1626 8 estimate estimate VB cord-023095-4dannjjm 1626 9 the the DT cord-023095-4dannjjm 1626 10 occurrence occurrence NN cord-023095-4dannjjm 1626 11 of of IN cord-023095-4dannjjm 1626 12 the the DT cord-023095-4dannjjm 1626 13 GYS-1 GYS-1 NNP cord-023095-4dannjjm 1626 14 mutation mutation NN cord-023095-4dannjjm 1626 15 in in IN cord-023095-4dannjjm 1626 16 Austrian Austrian NNP cord-023095-4dannjjm 1626 17 Haflingers Haflingers NNP cord-023095-4dannjjm 1626 18 and and CC cord-023095-4dannjjm 1626 19 establish establish VB cord-023095-4dannjjm 1626 20 which which WDT cord-023095-4dannjjm 1626 21 of of IN cord-023095-4dannjjm 1626 22 the the DT cord-023095-4dannjjm 1626 23 seven seven CD cord-023095-4dannjjm 1626 24 Haflinger Haflinger NNP cord-023095-4dannjjm 1626 25 sire sire NN cord-023095-4dannjjm 1626 26 lines line NNS cord-023095-4dannjjm 1626 27 appear appear VBP cord-023095-4dannjjm 1626 28 mostly mostly RB cord-023095-4dannjjm 1626 29 affected affect VBN cord-023095-4dannjjm 1626 30 . . . cord-023095-4dannjjm 1627 1 GYS-1 GYS-1 NNP cord-023095-4dannjjm 1627 2 genotyping genotyping NN cord-023095-4dannjjm 1627 3 of of IN cord-023095-4dannjjm 1627 4 50 50 CD cord-023095-4dannjjm 1627 5 randomly randomly RB cord-023095-4dannjjm 1627 6 chosen choose VBN cord-023095-4dannjjm 1627 7 Haflingers Haflingers NNPS cord-023095-4dannjjm 1627 8 was be VBD cord-023095-4dannjjm 1627 9 performed perform VBN cord-023095-4dannjjm 1627 10 with with IN cord-023095-4dannjjm 1627 11 a a DT cord-023095-4dannjjm 1627 12 validated validate VBN cord-023095-4dannjjm 1627 13 restriction restriction NN cord-023095-4dannjjm 1627 14 fragment fragment NN cord-023095-4dannjjm 1627 15 length length NN cord-023095-4dannjjm 1627 16 polymorphism polymorphism NN cord-023095-4dannjjm 1627 17 assay assay NN cord-023095-4dannjjm 1627 18 . . . cord-023095-4dannjjm 1628 1 Resting rest VBG cord-023095-4dannjjm 1628 2 and and CC cord-023095-4dannjjm 1628 3 post post JJ cord-023095-4dannjjm 1628 4 - - JJ cord-023095-4dannjjm 1628 5 exercise exercise JJ cord-023095-4dannjjm 1628 6 muscle muscle NN cord-023095-4dannjjm 1628 7 enzyme enzyme NN cord-023095-4dannjjm 1628 8 activities activity NNS cord-023095-4dannjjm 1628 9 ( ( -LRB- cord-023095-4dannjjm 1628 10 creatine creatine NN cord-023095-4dannjjm 1628 11 kinase kinase NN cord-023095-4dannjjm 1628 12 ( ( -LRB- cord-023095-4dannjjm 1628 13 CK CK NNP cord-023095-4dannjjm 1628 14 ) ) -RRB- cord-023095-4dannjjm 1628 15 , , , cord-023095-4dannjjm 1628 16 aspartate aspartate NN cord-023095-4dannjjm 1628 17 aminotransferase aminotransferase NN cord-023095-4dannjjm 1628 18 ( ( -LRB- cord-023095-4dannjjm 1628 19 AST AST NNP cord-023095-4dannjjm 1628 20 ) ) -RRB- cord-023095-4dannjjm 1628 21 , , , cord-023095-4dannjjm 1628 22 lacate lacate NN cord-023095-4dannjjm 1628 23 dehydrogenase dehydrogenase NN cord-023095-4dannjjm 1628 24 ( ( -LRB- cord-023095-4dannjjm 1628 25 LDH LDH NNP cord-023095-4dannjjm 1628 26 ) ) -RRB- cord-023095-4dannjjm 1628 27 ) ) -RRB- cord-023095-4dannjjm 1628 28 and and CC cord-023095-4dannjjm 1628 29 blood blood NN cord-023095-4dannjjm 1628 30 lactate lactate NN cord-023095-4dannjjm 1628 31 concentrations concentration NNS cord-023095-4dannjjm 1628 32 were be VBD cord-023095-4dannjjm 1628 33 compared compare VBN cord-023095-4dannjjm 1628 34 between between IN cord-023095-4dannjjm 1628 35 horses horse NNS cord-023095-4dannjjm 1628 36 with with IN cord-023095-4dannjjm 1628 37 and and CC cord-023095-4dannjjm 1628 38 without without IN cord-023095-4dannjjm 1628 39 the the DT cord-023095-4dannjjm 1628 40 mutation mutation NN cord-023095-4dannjjm 1628 41 . . . cord-023095-4dannjjm 1629 1 Among among IN cord-023095-4dannjjm 1629 2 the the DT cord-023095-4dannjjm 1629 3 50 50 CD cord-023095-4dannjjm 1629 4 horses horse NNS cord-023095-4dannjjm 1629 5 9 9 CD cord-023095-4dannjjm 1629 6 were be VBD cord-023095-4dannjjm 1629 7 heterozygous heterozygous JJ cord-023095-4dannjjm 1629 8 ( ( -LRB- cord-023095-4dannjjm 1629 9 HR HR NNP cord-023095-4dannjjm 1629 10 ) ) -RRB- cord-023095-4dannjjm 1629 11 carrier carrier NN cord-023095-4dannjjm 1629 12 of of IN cord-023095-4dannjjm 1629 13 the the DT cord-023095-4dannjjm 1629 14 mutation mutation NN cord-023095-4dannjjm 1629 15 . . . cord-023095-4dannjjm 1630 1 No no DT cord-023095-4dannjjm 1630 2 homozygotes homozygote NNS cord-023095-4dannjjm 1630 3 ( ( -LRB- cord-023095-4dannjjm 1630 4 HH HH NNP cord-023095-4dannjjm 1630 5 ) ) -RRB- cord-023095-4dannjjm 1630 6 were be VBD cord-023095-4dannjjm 1630 7 identified identify VBN cord-023095-4dannjjm 1630 8 . . . cord-023095-4dannjjm 1631 1 All all DT cord-023095-4dannjjm 1631 2 horses horse NNS cord-023095-4dannjjm 1631 3 with with IN cord-023095-4dannjjm 1631 4 the the DT cord-023095-4dannjjm 1631 5 GYS-1 GYS-1 NNP cord-023095-4dannjjm 1631 6 mutation mutation NN cord-023095-4dannjjm 1631 7 were be VBD cord-023095-4dannjjm 1631 8 descendents descendent NNS cord-023095-4dannjjm 1631 9 of of IN cord-023095-4dannjjm 1631 10 the the DT cord-023095-4dannjjm 1631 11 A A NNP cord-023095-4dannjjm 1631 12 - - : cord-023095-4dannjjm 1631 13 or or CC cord-023095-4dannjjm 1631 14 W w NN cord-023095-4dannjjm 1631 15 - - HYPH cord-023095-4dannjjm 1631 16 sire sire JJ cord-023095-4dannjjm 1631 17 lines line NNS cord-023095-4dannjjm 1631 18 . . . cord-023095-4dannjjm 1632 1 The the DT cord-023095-4dannjjm 1632 2 estimated estimated JJ cord-023095-4dannjjm 1632 3 HR hr NN cord-023095-4dannjjm 1632 4 prevalence prevalence NN cord-023095-4dannjjm 1632 5 was be VBD cord-023095-4dannjjm 1632 6 18 18 CD cord-023095-4dannjjm 1632 7 % % NN cord-023095-4dannjjm 1632 8 ( ( -LRB- cord-023095-4dannjjm 1632 9 95 95 CD cord-023095-4dannjjm 1632 10 % % NN cord-023095-4dannjjm 1632 11 CI ci NN cord-023095-4dannjjm 1632 12 : : : cord-023095-4dannjjm 1632 13 8.6 8.6 CD cord-023095-4dannjjm 1632 14 - - HYPH cord-023095-4dannjjm 1632 15 32.4 32.4 CD cord-023095-4dannjjm 1632 16 % % NN cord-023095-4dannjjm 1632 17 ) ) -RRB- cord-023095-4dannjjm 1632 18 . . . cord-023095-4dannjjm 1633 1 CK CK NNP cord-023095-4dannjjm 1633 2 activity activity NN cord-023095-4dannjjm 1633 3 after after IN cord-023095-4dannjjm 1633 4 exercise exercise NN cord-023095-4dannjjm 1633 5 ( ( -LRB- cord-023095-4dannjjm 1633 6 p p NN cord-023095-4dannjjm 1633 7 5 5 CD cord-023095-4dannjjm 1633 8 0.022 0.022 CD cord-023095-4dannjjm 1633 9 ) ) -RRB- cord-023095-4dannjjm 1633 10 was be VBD cord-023095-4dannjjm 1633 11 significantly significantly RB cord-023095-4dannjjm 1633 12 higher high JJR cord-023095-4dannjjm 1633 13 in in IN cord-023095-4dannjjm 1633 14 HR hr NN cord-023095-4dannjjm 1633 15 horses horse NNS cord-023095-4dannjjm 1633 16 compared compare VBN cord-023095-4dannjjm 1633 17 with with IN cord-023095-4dannjjm 1633 18 horses horse NNS cord-023095-4dannjjm 1633 19 not not RB cord-023095-4dannjjm 1633 20 carrying carry VBG cord-023095-4dannjjm 1633 21 the the DT cord-023095-4dannjjm 1633 22 mutation mutation NN cord-023095-4dannjjm 1633 23 ( ( -LRB- cord-023095-4dannjjm 1633 24 RR RR NNP cord-023095-4dannjjm 1633 25 ) ) -RRB- cord-023095-4dannjjm 1633 26 . . . cord-023095-4dannjjm 1634 1 AST ast NN cord-023095-4dannjjm 1634 2 activity activity NN cord-023095-4dannjjm 1634 3 was be VBD cord-023095-4dannjjm 1634 4 significantly significantly RB cord-023095-4dannjjm 1634 5 higher high JJR cord-023095-4dannjjm 1634 6 in in IN cord-023095-4dannjjm 1634 7 the the DT cord-023095-4dannjjm 1634 8 HR hr NN cord-023095-4dannjjm 1634 9 group group NN cord-023095-4dannjjm 1634 10 at at IN cord-023095-4dannjjm 1634 11 rest rest NN cord-023095-4dannjjm 1634 12 and and CC cord-023095-4dannjjm 1634 13 after after IN cord-023095-4dannjjm 1634 14 exercise exercise NN cord-023095-4dannjjm 1634 15 ( ( -LRB- cord-023095-4dannjjm 1634 16 p p NN cord-023095-4dannjjm 1634 17 o o CD cord-023095-4dannjjm 1634 18 0.001 0.001 CD cord-023095-4dannjjm 1634 19 ) ) -RRB- cord-023095-4dannjjm 1634 20 . . . cord-023095-4dannjjm 1635 1 There there EX cord-023095-4dannjjm 1635 2 was be VBD cord-023095-4dannjjm 1635 3 no no DT cord-023095-4dannjjm 1635 4 statistically statistically RB cord-023095-4dannjjm 1635 5 significant significant JJ cord-023095-4dannjjm 1635 6 difference difference NN cord-023095-4dannjjm 1635 7 in in IN cord-023095-4dannjjm 1635 8 resting rest VBG cord-023095-4dannjjm 1635 9 CK CK NNP cord-023095-4dannjjm 1635 10 , , , cord-023095-4dannjjm 1635 11 resting resting NN cord-023095-4dannjjm 1635 12 and and CC cord-023095-4dannjjm 1635 13 post post NN cord-023095-4dannjjm 1635 14 exercise exercise NN cord-023095-4dannjjm 1636 1 LDH LDH NNP cord-023095-4dannjjm 1636 2 activity activity NN cord-023095-4dannjjm 1636 3 or or CC cord-023095-4dannjjm 1636 4 blood blood NN cord-023095-4dannjjm 1636 5 lactate lactate NN cord-023095-4dannjjm 1636 6 between between IN cord-023095-4dannjjm 1636 7 HR hr NN cord-023095-4dannjjm 1636 8 and and CC cord-023095-4dannjjm 1636 9 RR rr NN cord-023095-4dannjjm 1636 10 . . . cord-023095-4dannjjm 1637 1 Results result NNS cord-023095-4dannjjm 1637 2 suggest suggest VBP cord-023095-4dannjjm 1637 3 that that IN cord-023095-4dannjjm 1637 4 the the DT cord-023095-4dannjjm 1637 5 prevalence prevalence NN cord-023095-4dannjjm 1637 6 of of IN cord-023095-4dannjjm 1637 7 HR hr NN cord-023095-4dannjjm 1637 8 in in IN cord-023095-4dannjjm 1637 9 the the DT cord-023095-4dannjjm 1637 10 Austrian austrian JJ cord-023095-4dannjjm 1637 11 Haflinger Haflinger NNP cord-023095-4dannjjm 1637 12 population population NN cord-023095-4dannjjm 1637 13 is be VBZ cord-023095-4dannjjm 1637 14 higher high JJR cord-023095-4dannjjm 1637 15 than than IN cord-023095-4dannjjm 1637 16 in in IN cord-023095-4dannjjm 1637 17 the the DT cord-023095-4dannjjm 1637 18 overall overall JJ cord-023095-4dannjjm 1637 19 Quarter Quarter NNP cord-023095-4dannjjm 1637 20 Horse Horse NNP cord-023095-4dannjjm 1637 21 population population NN cord-023095-4dannjjm 1637 22 and and CC cord-023095-4dannjjm 1637 23 might may MD cord-023095-4dannjjm 1637 24 be be VB cord-023095-4dannjjm 1637 25 as as RB cord-023095-4dannjjm 1637 26 high high JJ cord-023095-4dannjjm 1637 27 as as IN cord-023095-4dannjjm 1637 28 30 30 CD cord-023095-4dannjjm 1637 29 % % NN cord-023095-4dannjjm 1637 30 , , , cord-023095-4dannjjm 1637 31 similar similar JJ cord-023095-4dannjjm 1637 32 to to IN cord-023095-4dannjjm 1637 33 some some DT cord-023095-4dannjjm 1637 34 Draft Draft NNP cord-023095-4dannjjm 1637 35 horse horse NN cord-023095-4dannjjm 1637 36 breeds breed NNS cord-023095-4dannjjm 1637 37 . . . cord-023095-4dannjjm 1638 1 Further further JJ cord-023095-4dannjjm 1638 2 research research NN cord-023095-4dannjjm 1638 3 is be VBZ cord-023095-4dannjjm 1638 4 needed need VBN cord-023095-4dannjjm 1638 5 to to TO cord-023095-4dannjjm 1638 6 establish establish VB cord-023095-4dannjjm 1638 7 the the DT cord-023095-4dannjjm 1638 8 prevalence prevalence NN cord-023095-4dannjjm 1638 9 within within IN cord-023095-4dannjjm 1638 10 the the DT cord-023095-4dannjjm 1638 11 different different JJ cord-023095-4dannjjm 1638 12 breeding breeding NN cord-023095-4dannjjm 1638 13 lines line NNS cord-023095-4dannjjm 1638 14 . . . cord-023095-4dannjjm 1639 1 Hereditary hereditary JJ cord-023095-4dannjjm 1639 2 equine equine JJ cord-023095-4dannjjm 1639 3 regional regional JJ cord-023095-4dannjjm 1639 4 dermal dermal JJ cord-023095-4dannjjm 1639 5 asthenia asthenia NN cord-023095-4dannjjm 1639 6 ( ( -LRB- cord-023095-4dannjjm 1639 7 HERDA HERDA NNP cord-023095-4dannjjm 1639 8 ) ) -RRB- cord-023095-4dannjjm 1639 9 is be VBZ cord-023095-4dannjjm 1639 10 an an DT cord-023095-4dannjjm 1639 11 autosomal autosomal JJ cord-023095-4dannjjm 1639 12 recessive recessive JJ cord-023095-4dannjjm 1639 13 connective connective JJ cord-023095-4dannjjm 1639 14 tissue tissue NN cord-023095-4dannjjm 1639 15 disorder disorder NN cord-023095-4dannjjm 1639 16 affecting affect VBG cord-023095-4dannjjm 1639 17 Quarter Quarter NNP cord-023095-4dannjjm 1639 18 Horse Horse NNP cord-023095-4dannjjm 1639 19 lineages lineage NNS cord-023095-4dannjjm 1639 20 . . . cord-023095-4dannjjm 1640 1 1 1 LS cord-023095-4dannjjm 1641 1 Although although IN cord-023095-4dannjjm 1641 2 a a DT cord-023095-4dannjjm 1641 3 mutation mutation NN cord-023095-4dannjjm 1641 4 in in IN cord-023095-4dannjjm 1641 5 the the DT cord-023095-4dannjjm 1641 6 gene gene NN cord-023095-4dannjjm 1641 7 encoding encode VBG cord-023095-4dannjjm 1641 8 cyclophilin cyclophilin NNP cord-023095-4dannjjm 1641 9 B B NNP cord-023095-4dannjjm 1641 10 has have VBZ cord-023095-4dannjjm 1641 11 been be VBN cord-023095-4dannjjm 1641 12 genetically genetically RB cord-023095-4dannjjm 1641 13 linked link VBN cord-023095-4dannjjm 1641 14 to to IN cord-023095-4dannjjm 1641 15 HERDA HERDA NNP cord-023095-4dannjjm 1641 16 , , , cord-023095-4dannjjm 1641 17 its -PRON- PRP$ cord-023095-4dannjjm 1641 18 causal causal JJ cord-023095-4dannjjm 1641 19 association association NN cord-023095-4dannjjm 1641 20 with with IN cord-023095-4dannjjm 1641 21 the the DT cord-023095-4dannjjm 1641 22 disease disease NN cord-023095-4dannjjm 1641 23 is be VBZ cord-023095-4dannjjm 1641 24 not not RB cord-023095-4dannjjm 1641 25 yet yet RB cord-023095-4dannjjm 1641 26 documented document VBN cord-023095-4dannjjm 1641 27 . . . cord-023095-4dannjjm 1642 1 2 2 LS cord-023095-4dannjjm 1643 1 Previously previously RB cord-023095-4dannjjm 1643 2 , , , cord-023095-4dannjjm 1643 3 we -PRON- PRP cord-023095-4dannjjm 1643 4 demonstrated demonstrate VBD cord-023095-4dannjjm 1643 5 reductions reduction NNS cord-023095-4dannjjm 1643 6 in in IN cord-023095-4dannjjm 1643 7 ultimate ultimate JJ cord-023095-4dannjjm 1643 8 tensile tensile JJ cord-023095-4dannjjm 1643 9 strength strength NN cord-023095-4dannjjm 1643 10 ( ( -LRB- cord-023095-4dannjjm 1643 11 UTS UTS NNP cord-023095-4dannjjm 1643 12 ) ) -RRB- cord-023095-4dannjjm 1643 13 , , , cord-023095-4dannjjm 1643 14 modulus modulus NN cord-023095-4dannjjm 1643 15 of of IN cord-023095-4dannjjm 1643 16 elasticity elasticity NN cord-023095-4dannjjm 1643 17 , , , cord-023095-4dannjjm 1643 18 and and CC cord-023095-4dannjjm 1643 19 energy energy NN cord-023095-4dannjjm 1643 20 to to IN cord-023095-4dannjjm 1643 21 failure failure NN cord-023095-4dannjjm 1643 22 ( ( -LRB- cord-023095-4dannjjm 1643 23 toughness toughness NN cord-023095-4dannjjm 1643 24 ) ) -RRB- cord-023095-4dannjjm 1643 25 of of IN cord-023095-4dannjjm 1643 26 skin skin NN cord-023095-4dannjjm 1643 27 from from IN cord-023095-4dannjjm 1643 28 many many JJ cord-023095-4dannjjm 1643 29 corporal corporal JJ cord-023095-4dannjjm 1643 30 regions region NNS cord-023095-4dannjjm 1643 31 of of IN cord-023095-4dannjjm 1643 32 HERDA HERDA NNP cord-023095-4dannjjm 1643 33 animals animal NNS cord-023095-4dannjjm 1643 34 . . . cord-023095-4dannjjm 1644 1 3 3 LS cord-023095-4dannjjm 1645 1 Given give VBN cord-023095-4dannjjm 1645 2 the the DT cord-023095-4dannjjm 1645 3 presumed presume VBN cord-023095-4dannjjm 1645 4 relationship relationship NN cord-023095-4dannjjm 1645 5 between between IN cord-023095-4dannjjm 1645 6 HER HER NNP cord-023095-4dannjjm 1645 7 - - HYPH cord-023095-4dannjjm 1645 8 DA DA NNP cord-023095-4dannjjm 1645 9 and and CC cord-023095-4dannjjm 1645 10 abnormal abnormal JJ cord-023095-4dannjjm 1645 11 collagen collagen NN cord-023095-4dannjjm 1645 12 structure structure NN cord-023095-4dannjjm 1645 13 , , , cord-023095-4dannjjm 1645 14 and and CC cord-023095-4dannjjm 1645 15 the the DT cord-023095-4dannjjm 1645 16 predominance predominance NN cord-023095-4dannjjm 1645 17 of of IN cord-023095-4dannjjm 1645 18 Type type NN cord-023095-4dannjjm 1645 19 I -PRON- PRP cord-023095-4dannjjm 1645 20 collagen collagen NN cord-023095-4dannjjm 1645 21 in in IN cord-023095-4dannjjm 1645 22 skin skin NN cord-023095-4dannjjm 1645 23 , , , cord-023095-4dannjjm 1645 24 we -PRON- PRP cord-023095-4dannjjm 1645 25 hypothesized hypothesize VBD cord-023095-4dannjjm 1645 26 that that IN cord-023095-4dannjjm 1645 27 altered alter VBN cord-023095-4dannjjm 1645 28 biomechanical biomechanical JJ cord-023095-4dannjjm 1645 29 properties property NNS cord-023095-4dannjjm 1645 30 would would MD cord-023095-4dannjjm 1645 31 be be VB cord-023095-4dannjjm 1645 32 detected detect VBN cord-023095-4dannjjm 1645 33 in in IN cord-023095-4dannjjm 1645 34 tendons tendon NNS cord-023095-4dannjjm 1645 35 which which WDT cord-023095-4dannjjm 1645 36 are be VBP cord-023095-4dannjjm 1645 37 rich rich JJ cord-023095-4dannjjm 1645 38 in in IN cord-023095-4dannjjm 1645 39 Type type NN cord-023095-4dannjjm 1645 40 I -PRON- PRP cord-023095-4dannjjm 1645 41 collagen collagen NN cord-023095-4dannjjm 1645 42 . . . cord-023095-4dannjjm 1646 1 To to TO cord-023095-4dannjjm 1646 2 evaluate evaluate VB cord-023095-4dannjjm 1646 3 this this DT cord-023095-4dannjjm 1646 4 hypothesis hypothesis NN cord-023095-4dannjjm 1646 5 we -PRON- PRP cord-023095-4dannjjm 1646 6 compared compare VBD cord-023095-4dannjjm 1646 7 the the DT cord-023095-4dannjjm 1646 8 UTS UTS NNP cord-023095-4dannjjm 1646 9 , , , cord-023095-4dannjjm 1646 10 modulus modulus NN cord-023095-4dannjjm 1646 11 of of IN cord-023095-4dannjjm 1646 12 elasticity elasticity NN cord-023095-4dannjjm 1646 13 , , , cord-023095-4dannjjm 1646 14 and and CC cord-023095-4dannjjm 1646 15 energy energy NN cord-023095-4dannjjm 1646 16 to to IN cord-023095-4dannjjm 1646 17 failure failure NN cord-023095-4dannjjm 1646 18 of of IN cord-023095-4dannjjm 1646 19 forelimb forelimb NN cord-023095-4dannjjm 1646 20 deep deep JJ cord-023095-4dannjjm 1646 21 digital digital JJ cord-023095-4dannjjm 1646 22 flexor flexor NN cord-023095-4dannjjm 1646 23 tendons tendon NNS cord-023095-4dannjjm 1646 24 ( ( -LRB- cord-023095-4dannjjm 1646 25 DFT DFT NNP cord-023095-4dannjjm 1646 26 ) ) -RRB- cord-023095-4dannjjm 1646 27 from from IN cord-023095-4dannjjm 1646 28 six six CD cord-023095-4dannjjm 1646 29 HERDA HERDA NNP cord-023095-4dannjjm 1646 30 horses horse NNS cord-023095-4dannjjm 1646 31 to to IN cord-023095-4dannjjm 1646 32 six six CD cord-023095-4dannjjm 1646 33 age age NN cord-023095-4dannjjm 1646 34 - - HYPH cord-023095-4dannjjm 1646 35 matched match VBN cord-023095-4dannjjm 1646 36 controls control NNS cord-023095-4dannjjm 1646 37 . . . cord-023095-4dannjjm 1647 1 Isolated isolated JJ cord-023095-4dannjjm 1647 2 DFT DFT NNP cord-023095-4dannjjm 1647 3 was be VBD cord-023095-4dannjjm 1647 4 secured secure VBN cord-023095-4dannjjm 1647 5 and and CC cord-023095-4dannjjm 1647 6 pulled pull VBN cord-023095-4dannjjm 1647 7 to to IN cord-023095-4dannjjm 1647 8 failure failure NN cord-023095-4dannjjm 1647 9 on on IN cord-023095-4dannjjm 1647 10 an an DT cord-023095-4dannjjm 1647 11 Instron Instron NNP cord-023095-4dannjjm 1647 12 s s POS cord-023095-4dannjjm 1647 13 1011 1011 CD cord-023095-4dannjjm 1647 14 Universal Universal NNP cord-023095-4dannjjm 1647 15 Testing Testing NNP cord-023095-4dannjjm 1647 16 Instrument Instrument NNP cord-023095-4dannjjm 1647 17 using use VBG cord-023095-4dannjjm 1647 18 purpose purpose NN cord-023095-4dannjjm 1647 19 - - HYPH cord-023095-4dannjjm 1647 20 built build VBN cord-023095-4dannjjm 1647 21 cryogenic cryogenic JJ cord-023095-4dannjjm 1647 22 clamps clamp NNS cord-023095-4dannjjm 1647 23 . . . cord-023095-4dannjjm 1648 1 Analysis analysis NN cord-023095-4dannjjm 1648 2 of of IN cord-023095-4dannjjm 1648 3 Variance variance NN cord-023095-4dannjjm 1648 4 was be VBD cord-023095-4dannjjm 1648 5 executed execute VBN cord-023095-4dannjjm 1648 6 using use VBG cord-023095-4dannjjm 1648 7 SAS SAS NNP cord-023095-4dannjjm 1648 8 9.2 9.2 CD cord-023095-4dannjjm 1648 9 PROC proc NN cord-023095-4dannjjm 1648 10 GLIMMIX GLIMMIX NNP cord-023095-4dannjjm 1648 11 program program NN cord-023095-4dannjjm 1648 12 ( ( -LRB- cord-023095-4dannjjm 1648 13 SAS SAS NNP cord-023095-4dannjjm 1648 14 Institute Institute NNP cord-023095-4dannjjm 1648 15 , , , cord-023095-4dannjjm 1648 16 2009 2009 CD cord-023095-4dannjjm 1648 17 ) ) -RRB- cord-023095-4dannjjm 1648 18 . . . cord-023095-4dannjjm 1649 1 P p NN cord-023095-4dannjjm 1649 2 - - HYPH cord-023095-4dannjjm 1649 3 values value NNS cord-023095-4dannjjm 1649 4 0.05 0.05 CD cord-023095-4dannjjm 1649 5 were be VBD cord-023095-4dannjjm 1649 6 identified identify VBN cord-023095-4dannjjm 1649 7 as as IN cord-023095-4dannjjm 1649 8 significant significant JJ cord-023095-4dannjjm 1649 9 . . . cord-023095-4dannjjm 1650 1 UTS UTS NNP cord-023095-4dannjjm 1650 2 and and CC cord-023095-4dannjjm 1650 3 modulus modulus NN cord-023095-4dannjjm 1650 4 of of IN cord-023095-4dannjjm 1650 5 elasticity elasticity NN cord-023095-4dannjjm 1650 6 were be VBD cord-023095-4dannjjm 1650 7 significantly significantly RB cord-023095-4dannjjm 1650 8 lower low JJR cord-023095-4dannjjm 1650 9 in in IN cord-023095-4dannjjm 1650 10 HERDA HERDA NNP cord-023095-4dannjjm 1650 11 DFT DFT NNP cord-023095-4dannjjm 1650 12 when when WRB cord-023095-4dannjjm 1650 13 compared compare VBN cord-023095-4dannjjm 1650 14 with with IN cord-023095-4dannjjm 1650 15 controls control NNS cord-023095-4dannjjm 1650 16 ( ( -LRB- cord-023095-4dannjjm 1650 17 P p NN cord-023095-4dannjjm 1650 18 o o CD cord-023095-4dannjjm 1650 19 0.0001 0.0001 CD cord-023095-4dannjjm 1650 20 ) ) -RRB- cord-023095-4dannjjm 1650 21 ; ; : cord-023095-4dannjjm 1650 22 energy energy NN cord-023095-4dannjjm 1650 23 to to IN cord-023095-4dannjjm 1650 24 failure failure NN cord-023095-4dannjjm 1650 25 did do VBD cord-023095-4dannjjm 1650 26 not not RB cord-023095-4dannjjm 1650 27 differ differ VB cord-023095-4dannjjm 1650 28 between between IN cord-023095-4dannjjm 1650 29 groups group NNS cord-023095-4dannjjm 1650 30 . . . cord-023095-4dannjjm 1651 1 These these DT cord-023095-4dannjjm 1651 2 findings finding NNS cord-023095-4dannjjm 1651 3 document document NN cord-023095-4dannjjm 1651 4 abnormal abnormal JJ cord-023095-4dannjjm 1651 5 biomechanics biomechanic NNS cord-023095-4dannjjm 1651 6 in in IN cord-023095-4dannjjm 1651 7 HERDA HERDA NNP cord-023095-4dannjjm 1651 8 tendon tendon NN cord-023095-4dannjjm 1651 9 , , , cord-023095-4dannjjm 1651 10 leading lead VBG cord-023095-4dannjjm 1651 11 us -PRON- PRP cord-023095-4dannjjm 1651 12 to to TO cord-023095-4dannjjm 1651 13 postulate postulate VB cord-023095-4dannjjm 1651 14 that that IN cord-023095-4dannjjm 1651 15 lower low JJR cord-023095-4dannjjm 1651 16 UTS UTS NNP cord-023095-4dannjjm 1651 17 and and CC cord-023095-4dannjjm 1651 18 modulus modulus NN cord-023095-4dannjjm 1651 19 of of IN cord-023095-4dannjjm 1651 20 elasticity elasticity NN cord-023095-4dannjjm 1651 21 associated associate VBN cord-023095-4dannjjm 1651 22 with with IN cord-023095-4dannjjm 1651 23 the the DT cord-023095-4dannjjm 1651 24 HERDA HERDA NNP cord-023095-4dannjjm 1651 25 defect defect NN cord-023095-4dannjjm 1651 26 could could MD cord-023095-4dannjjm 1651 27 convey convey VB cord-023095-4dannjjm 1651 28 a a DT cord-023095-4dannjjm 1651 29 competitive competitive JJ cord-023095-4dannjjm 1651 30 advantage advantage NN cord-023095-4dannjjm 1651 31 in in IN cord-023095-4dannjjm 1651 32 the the DT cord-023095-4dannjjm 1651 33 athletic athletic JJ cord-023095-4dannjjm 1651 34 disciplines discipline NNS cord-023095-4dannjjm 1651 35 in in IN cord-023095-4dannjjm 1651 36 which which WDT cord-023095-4dannjjm 1651 37 this this DT cord-023095-4dannjjm 1651 38 defect defect NN cord-023095-4dannjjm 1651 39 has have VBZ cord-023095-4dannjjm 1651 40 segregated segregate VBN cord-023095-4dannjjm 1651 41 . . . cord-023095-4dannjjm 1652 1 ( ( -LRB- cord-023095-4dannjjm 1652 2 References reference NNS cord-023095-4dannjjm 1652 3 on on IN cord-023095-4dannjjm 1652 4 request request NN cord-023095-4dannjjm 1652 5 ) ) -RRB- cord-023095-4dannjjm 1652 6 . . . cord-023095-4dannjjm 1653 1 A a DT cord-023095-4dannjjm 1653 2 proprietary proprietary JJ cord-023095-4dannjjm 1653 3 herbal herbal JJ cord-023095-4dannjjm 1653 4 biocontamination biocontamination NN cord-023095-4dannjjm 1653 5 product product NN cord-023095-4dannjjm 1653 6 ( ( -LRB- cord-023095-4dannjjm 1653 7 BIOS BIOS NNP cord-023095-4dannjjm 1653 8 ) ) -RRB- cord-023095-4dannjjm 1653 9 approved approve VBN cord-023095-4dannjjm 1653 10 for for IN cord-023095-4dannjjm 1653 11 cosmetic cosmetic JJ cord-023095-4dannjjm 1653 12 use use NN cord-023095-4dannjjm 1653 13 in in IN cord-023095-4dannjjm 1653 14 France France NNP cord-023095-4dannjjm 1653 15 , , , cord-023095-4dannjjm 1653 16 inhibits inhibit VBZ cord-023095-4dannjjm 1653 17 proliferation proliferation NN cord-023095-4dannjjm 1653 18 of of IN cord-023095-4dannjjm 1653 19 medically medically RB cord-023095-4dannjjm 1653 20 relevant relevant JJ cord-023095-4dannjjm 1653 21 bacteria bacteria NNS cord-023095-4dannjjm 1653 22 , , , cord-023095-4dannjjm 1653 23 mold mold NN cord-023095-4dannjjm 1653 24 , , , cord-023095-4dannjjm 1653 25 and and CC cord-023095-4dannjjm 1653 26 viruses virus NNS cord-023095-4dannjjm 1653 27 . . . cord-023095-4dannjjm 1654 1 These these DT cord-023095-4dannjjm 1654 2 properties property NNS cord-023095-4dannjjm 1654 3 make make VBP cord-023095-4dannjjm 1654 4 BIOS bio NNS cord-023095-4dannjjm 1654 5 potentially potentially RB cord-023095-4dannjjm 1654 6 useful useful JJ cord-023095-4dannjjm 1654 7 as as IN cord-023095-4dannjjm 1654 8 a a DT cord-023095-4dannjjm 1654 9 topical topical JJ cord-023095-4dannjjm 1654 10 wound wound NN cord-023095-4dannjjm 1654 11 medication medication NN cord-023095-4dannjjm 1654 12 , , , cord-023095-4dannjjm 1654 13 prompting prompt VBG cord-023095-4dannjjm 1654 14 us -PRON- PRP cord-023095-4dannjjm 1654 15 to to TO cord-023095-4dannjjm 1654 16 compare compare VB cord-023095-4dannjjm 1654 17 BIOS bio NNS cord-023095-4dannjjm 1654 18 to to IN cord-023095-4dannjjm 1654 19 silver silver NN cord-023095-4dannjjm 1654 20 sulfadiazine sulfadiazine NNP cord-023095-4dannjjm 1654 21 ( ( -LRB- cord-023095-4dannjjm 1654 22 SSD SSD NNP cord-023095-4dannjjm 1654 23 ) ) -RRB- cord-023095-4dannjjm 1654 24 in in IN cord-023095-4dannjjm 1654 25 a a DT cord-023095-4dannjjm 1654 26 distal distal JJ cord-023095-4dannjjm 1654 27 extremity extremity NN cord-023095-4dannjjm 1654 28 wound wound NN cord-023095-4dannjjm 1654 29 healing healing NN cord-023095-4dannjjm 1654 30 model model NN cord-023095-4dannjjm 1654 31 in in IN cord-023095-4dannjjm 1654 32 horses horse NNS cord-023095-4dannjjm 1654 33 . . . cord-023095-4dannjjm 1655 1 1 1 LS cord-023095-4dannjjm 1656 1 Using use VBG cord-023095-4dannjjm 1656 2 general general JJ cord-023095-4dannjjm 1656 3 anesthesia anesthesia NNP cord-023095-4dannjjm 1656 4 , , , cord-023095-4dannjjm 1656 5 two two CD cord-023095-4dannjjm 1656 6 6.25 6.25 CD cord-023095-4dannjjm 1656 7 cm cm NNS cord-023095-4dannjjm 1656 8 2 2 CD cord-023095-4dannjjm 1656 9 wounds wound NNS cord-023095-4dannjjm 1656 10 were be VBD cord-023095-4dannjjm 1656 11 aseptically aseptically RB cord-023095-4dannjjm 1656 12 created create VBN cord-023095-4dannjjm 1656 13 on on IN cord-023095-4dannjjm 1656 14 the the DT cord-023095-4dannjjm 1656 15 dorsomedial dorsomedial JJ cord-023095-4dannjjm 1656 16 aspect aspect NN cord-023095-4dannjjm 1656 17 of of IN cord-023095-4dannjjm 1656 18 all all DT cord-023095-4dannjjm 1656 19 limbs limb NNS cord-023095-4dannjjm 1656 20 . . . cord-023095-4dannjjm 1657 1 For for IN cord-023095-4dannjjm 1657 2 the the DT cord-023095-4dannjjm 1657 3 duration duration NN cord-023095-4dannjjm 1657 4 of of IN cord-023095-4dannjjm 1657 5 the the DT cord-023095-4dannjjm 1657 6 study study NN cord-023095-4dannjjm 1657 7 , , , cord-023095-4dannjjm 1657 8 two two CD cord-023095-4dannjjm 1657 9 contralateral contralateral JJ cord-023095-4dannjjm 1657 10 limbs limb NNS cord-023095-4dannjjm 1657 11 were be VBD cord-023095-4dannjjm 1657 12 randomly randomly RB cord-023095-4dannjjm 1657 13 chosen choose VBN cord-023095-4dannjjm 1657 14 to to TO cord-023095-4dannjjm 1657 15 be be VB cord-023095-4dannjjm 1657 16 bandaged bandage VBN cord-023095-4dannjjm 1657 17 ; ; : cord-023095-4dannjjm 1657 18 the the DT cord-023095-4dannjjm 1657 19 other other JJ cord-023095-4dannjjm 1657 20 two two CD cord-023095-4dannjjm 1657 21 limbs limb NNS cord-023095-4dannjjm 1657 22 were be VBD cord-023095-4dannjjm 1657 23 un un NNP cord-023095-4dannjjm 1657 24 - - JJ cord-023095-4dannjjm 1657 25 bandaged bandage VBN cord-023095-4dannjjm 1658 1 -with -with : cord-023095-4dannjjm 1658 2 one one CD cord-023095-4dannjjm 1658 3 limb limb NN cord-023095-4dannjjm 1658 4 of of IN cord-023095-4dannjjm 1658 5 each each DT cord-023095-4dannjjm 1658 6 group group NN cord-023095-4dannjjm 1658 7 being be VBG cord-023095-4dannjjm 1658 8 treated treat VBN cord-023095-4dannjjm 1658 9 with with IN cord-023095-4dannjjm 1658 10 10 10 CD cord-023095-4dannjjm 1658 11 % % NN cord-023095-4dannjjm 1658 12 BIOS bio NNS cord-023095-4dannjjm 1658 13 and and CC cord-023095-4dannjjm 1658 14 the the DT cord-023095-4dannjjm 1658 15 other other JJ cord-023095-4dannjjm 1658 16 with with IN cord-023095-4dannjjm 1658 17 SSD SSD NNP cord-023095-4dannjjm 1658 18 . . . cord-023095-4dannjjm 1659 1 For for IN cord-023095-4dannjjm 1659 2 each each DT cord-023095-4dannjjm 1659 3 limb limb NN cord-023095-4dannjjm 1659 4 the the DT cord-023095-4dannjjm 1659 5 most most RBS cord-023095-4dannjjm 1659 6 proximal proximal JJ cord-023095-4dannjjm 1659 7 wound wound NN cord-023095-4dannjjm 1659 8 served serve VBD cord-023095-4dannjjm 1659 9 as as IN cord-023095-4dannjjm 1659 10 an an DT cord-023095-4dannjjm 1659 11 untreated untreated JJ cord-023095-4dannjjm 1659 12 control control NN cord-023095-4dannjjm 1659 13 . . . cord-023095-4dannjjm 1660 1 Every every DT cord-023095-4dannjjm 1660 2 48 48 CD cord-023095-4dannjjm 1660 3 hours hour NNS cord-023095-4dannjjm 1660 4 wounds wound NNS cord-023095-4dannjjm 1660 5 were be VBD cord-023095-4dannjjm 1660 6 evaluated evaluate VBN cord-023095-4dannjjm 1660 7 , , , cord-023095-4dannjjm 1660 8 digitally digitally RB cord-023095-4dannjjm 1660 9 photographed photograph VBN cord-023095-4dannjjm 1660 10 , , , cord-023095-4dannjjm 1660 11 and and CC cord-023095-4dannjjm 1660 12 perimeter perimeter NN cord-023095-4dannjjm 1660 13 and and CC cord-023095-4dannjjm 1660 14 area area NN cord-023095-4dannjjm 1660 15 determined determine VBD cord-023095-4dannjjm 1660 16 using use VBG cord-023095-4dannjjm 1660 17 morphometric morphometric JJ cord-023095-4dannjjm 1660 18 software software NN cord-023095-4dannjjm 1660 19 ( ( -LRB- cord-023095-4dannjjm 1660 20 ImageJ imagej RB cord-023095-4dannjjm 1660 21 , , , cord-023095-4dannjjm 1660 22 NIH NIH NNP cord-023095-4dannjjm 1660 23 ) ) -RRB- cord-023095-4dannjjm 1660 24 . . . cord-023095-4dannjjm 1661 1 Analysis analysis NN cord-023095-4dannjjm 1661 2 of of IN cord-023095-4dannjjm 1661 3 variance variance NN cord-023095-4dannjjm 1661 4 did do VBD cord-023095-4dannjjm 1661 5 not not RB cord-023095-4dannjjm 1661 6 identify identify VB cord-023095-4dannjjm 1661 7 significant significant JJ cord-023095-4dannjjm 1661 8 differences difference NNS cord-023095-4dannjjm 1661 9 between between IN cord-023095-4dannjjm 1661 10 SSD SSD NNP cord-023095-4dannjjm 1661 11 or or CC cord-023095-4dannjjm 1661 12 BIOS bios NN cord-023095-4dannjjm 1661 13 treatment treatment NN cord-023095-4dannjjm 1661 14 for for IN cord-023095-4dannjjm 1661 15 wound wound NN cord-023095-4dannjjm 1661 16 perimeter perimeter NN cord-023095-4dannjjm 1661 17 ( ( -LRB- cord-023095-4dannjjm 1661 18 p p NN cord-023095-4dannjjm 1661 19 5 5 CD cord-023095-4dannjjm 1661 20 0.76 0.76 CD cord-023095-4dannjjm 1661 21 ) ) -RRB- cord-023095-4dannjjm 1661 22 or or CC cord-023095-4dannjjm 1661 23 area area NN cord-023095-4dannjjm 1661 24 ( ( -LRB- cord-023095-4dannjjm 1661 25 p p NN cord-023095-4dannjjm 1661 26 5 5 CD cord-023095-4dannjjm 1661 27 0.95 0.95 CD cord-023095-4dannjjm 1661 28 ) ) -RRB- cord-023095-4dannjjm 1661 29 . . . cord-023095-4dannjjm 1662 1 At at IN cord-023095-4dannjjm 1662 2 individual individual JJ cord-023095-4dannjjm 1662 3 time time NN cord-023095-4dannjjm 1662 4 points point VBZ cord-023095-4dannjjm 1662 5 the the DT cord-023095-4dannjjm 1662 6 effect effect NN cord-023095-4dannjjm 1662 7 of of IN cord-023095-4dannjjm 1662 8 bandaging bandaging NN cord-023095-4dannjjm 1662 9 was be VBD cord-023095-4dannjjm 1662 10 significant significant JJ cord-023095-4dannjjm 1662 11 when when WRB cord-023095-4dannjjm 1662 12 area area NN cord-023095-4dannjjm 1662 13 was be VBD cord-023095-4dannjjm 1662 14 evaluated evaluate VBN cord-023095-4dannjjm 1662 15 ( ( -LRB- cord-023095-4dannjjm 1662 16 p p NN cord-023095-4dannjjm 1662 17 5 5 CD cord-023095-4dannjjm 1662 18 0.019 0.019 CD cord-023095-4dannjjm 1662 19 ) ) -RRB- cord-023095-4dannjjm 1662 20 and and CC cord-023095-4dannjjm 1662 21 trended trend VBD cord-023095-4dannjjm 1662 22 toward toward IN cord-023095-4dannjjm 1662 23 significance significance NN cord-023095-4dannjjm 1662 24 for for IN cord-023095-4dannjjm 1662 25 perimeter perimeter NN cord-023095-4dannjjm 1662 26 ( ( -LRB- cord-023095-4dannjjm 1662 27 p p NN cord-023095-4dannjjm 1662 28 5 5 CD cord-023095-4dannjjm 1662 29 0.084 0.084 CD cord-023095-4dannjjm 1662 30 ) ) -RRB- cord-023095-4dannjjm 1662 31 comparisons comparison NNS cord-023095-4dannjjm 1662 32 , , , cord-023095-4dannjjm 1662 33 substantiating substantiate VBG cord-023095-4dannjjm 1662 34 published publish VBN cord-023095-4dannjjm 1662 35 reports report NNS cord-023095-4dannjjm 1662 36 that that IN cord-023095-4dannjjm 1662 37 bandaging bandaging NN cord-023095-4dannjjm 1662 38 modifies modify VBZ cord-023095-4dannjjm 1662 39 wound wind VBN cord-023095-4dannjjm 1662 40 healing healing NN cord-023095-4dannjjm 1662 41 . . . cord-023095-4dannjjm 1663 1 Difference difference NN cord-023095-4dannjjm 1663 2 in in IN cord-023095-4dannjjm 1663 3 perimeter perimeter NN cord-023095-4dannjjm 1663 4 and and CC cord-023095-4dannjjm 1663 5 area area NN cord-023095-4dannjjm 1663 6 between between IN cord-023095-4dannjjm 1663 7 control control NN cord-023095-4dannjjm 1663 8 and and CC cord-023095-4dannjjm 1663 9 treatment treatment NN cord-023095-4dannjjm 1663 10 were be VBD cord-023095-4dannjjm 1663 11 highly highly RB cord-023095-4dannjjm 1663 12 significant significant JJ cord-023095-4dannjjm 1663 13 ( ( -LRB- cord-023095-4dannjjm 1663 14 p p NN cord-023095-4dannjjm 1663 15 o o NN cord-023095-4dannjjm 1663 16 0.0001 0.0001 CD cord-023095-4dannjjm 1663 17 ) ) -RRB- cord-023095-4dannjjm 1663 18 , , , cord-023095-4dannjjm 1663 19 substantiating substantiate VBG cord-023095-4dannjjm 1663 20 the the DT cord-023095-4dannjjm 1663 21 importance importance NN cord-023095-4dannjjm 1663 22 of of IN cord-023095-4dannjjm 1663 23 topical topical JJ cord-023095-4dannjjm 1663 24 treatment treatment NN cord-023095-4dannjjm 1663 25 . . . cord-023095-4dannjjm 1664 1 Over over IN cord-023095-4dannjjm 1664 2 the the DT cord-023095-4dannjjm 1664 3 study study NN cord-023095-4dannjjm 1664 4 duration duration NN cord-023095-4dannjjm 1664 5 , , , cord-023095-4dannjjm 1664 6 effects effect NNS cord-023095-4dannjjm 1664 7 of of IN cord-023095-4dannjjm 1664 8 bandaging bandaging NN cord-023095-4dannjjm 1664 9 ( ( -LRB- cord-023095-4dannjjm 1664 10 p p NN cord-023095-4dannjjm 1664 11 o o NN cord-023095-4dannjjm 1664 12 0.0001 0.0001 CD cord-023095-4dannjjm 1664 13 ) ) -RRB- cord-023095-4dannjjm 1664 14 and and CC cord-023095-4dannjjm 1664 15 topical topical JJ cord-023095-4dannjjm 1664 16 treatment treatment NN cord-023095-4dannjjm 1664 17 ( ( -LRB- cord-023095-4dannjjm 1664 18 perimeter perimeter NN cord-023095-4dannjjm 1664 19 p p NN cord-023095-4dannjjm 1664 20 o o NN cord-023095-4dannjjm 1664 21 0.0001 0.0001 CD cord-023095-4dannjjm 1664 22 ; ; : cord-023095-4dannjjm 1664 23 area area NN cord-023095-4dannjjm 1664 24 p p NN cord-023095-4dannjjm 1664 25 5 5 CD cord-023095-4dannjjm 1664 26 0.0016 0.0016 CD cord-023095-4dannjjm 1664 27 ) ) -RRB- cord-023095-4dannjjm 1664 28 continued continue VBD cord-023095-4dannjjm 1664 29 to to TO cord-023095-4dannjjm 1664 30 be be VB cord-023095-4dannjjm 1664 31 highly highly RB cord-023095-4dannjjm 1664 32 significant significant JJ cord-023095-4dannjjm 1664 33 . . . cord-023095-4dannjjm 1665 1 BIOS bios NN cord-023095-4dannjjm 1665 2 performance performance NN cord-023095-4dannjjm 1665 3 in in IN cord-023095-4dannjjm 1665 4 the the DT cord-023095-4dannjjm 1665 5 equine equine JJ cord-023095-4dannjjm 1665 6 distal distal JJ cord-023095-4dannjjm 1665 7 extremity extremity NN cord-023095-4dannjjm 1665 8 wound wound NN cord-023095-4dannjjm 1665 9 model model NN cord-023095-4dannjjm 1665 10 was be VBD cord-023095-4dannjjm 1665 11 equivalent equivalent JJ cord-023095-4dannjjm 1665 12 to to IN cord-023095-4dannjjm 1665 13 SSD SSD NNP cord-023095-4dannjjm 1665 14 . . . cord-023095-4dannjjm 1666 1 Both both DT cord-023095-4dannjjm 1666 2 bandaging bandaging NN cord-023095-4dannjjm 1666 3 and and CC cord-023095-4dannjjm 1666 4 topical topical JJ cord-023095-4dannjjm 1666 5 treatment treatment NN cord-023095-4dannjjm 1666 6 significantly significantly RB cord-023095-4dannjjm 1666 7 impacted impact VBD cord-023095-4dannjjm 1666 8 wound wound NN cord-023095-4dannjjm 1666 9 healing healing NN cord-023095-4dannjjm 1666 10 . . . cord-023095-4dannjjm 1667 1 This this DT cord-023095-4dannjjm 1667 2 effect effect NN cord-023095-4dannjjm 1667 3 was be VBD cord-023095-4dannjjm 1667 4 compounded compound VBN cord-023095-4dannjjm 1667 5 when when WRB cord-023095-4dannjjm 1667 6 both both DT cord-023095-4dannjjm 1667 7 variables variable NNS cord-023095-4dannjjm 1667 8 were be VBD cord-023095-4dannjjm 1667 9 evaluated evaluate VBN cord-023095-4dannjjm 1667 10 over over IN cord-023095-4dannjjm 1667 11 time time NN cord-023095-4dannjjm 1667 12 . . . cord-023095-4dannjjm 1668 1 Radiolabeled Radiolabeled NNP cord-023095-4dannjjm 1668 2 leukocytes leukocyte NNS cord-023095-4dannjjm 1668 3 are be VBP cord-023095-4dannjjm 1668 4 the the DT cord-023095-4dannjjm 1668 5 only only JJ cord-023095-4dannjjm 1668 6 scintigraphic scintigraphic JJ cord-023095-4dannjjm 1668 7 method method NN cord-023095-4dannjjm 1668 8 currently currently RB cord-023095-4dannjjm 1668 9 available available JJ cord-023095-4dannjjm 1668 10 for for IN cord-023095-4dannjjm 1668 11 identifying identify VBG cord-023095-4dannjjm 1668 12 sites site NNS cord-023095-4dannjjm 1668 13 of of IN cord-023095-4dannjjm 1668 14 infection infection NN cord-023095-4dannjjm 1668 15 and/or and/or CC cord-023095-4dannjjm 1668 16 inflammation inflammation NN cord-023095-4dannjjm 1668 17 in in IN cord-023095-4dannjjm 1668 18 horses horse NNS cord-023095-4dannjjm 1668 19 ; ; : cord-023095-4dannjjm 1668 20 however however RB cord-023095-4dannjjm 1668 21 the the DT cord-023095-4dannjjm 1668 22 clinical clinical JJ cord-023095-4dannjjm 1668 23 applicability applicability NN cord-023095-4dannjjm 1668 24 of of IN cord-023095-4dannjjm 1668 25 this this DT cord-023095-4dannjjm 1668 26 technique technique NN cord-023095-4dannjjm 1668 27 is be VBZ cord-023095-4dannjjm 1668 28 limited limit VBN cord-023095-4dannjjm 1668 29 by by IN cord-023095-4dannjjm 1668 30 expense expense NN cord-023095-4dannjjm 1668 31 and and CC cord-023095-4dannjjm 1668 32 poor poor JJ cord-023095-4dannjjm 1668 33 efficacy efficacy NN cord-023095-4dannjjm 1668 34 . . . cord-023095-4dannjjm 1669 1 This this DT cord-023095-4dannjjm 1669 2 pilot pilot NN cord-023095-4dannjjm 1669 3 study study NN cord-023095-4dannjjm 1669 4 compares compare VBZ cord-023095-4dannjjm 1669 5 the the DT cord-023095-4dannjjm 1669 6 accumulation accumulation NN cord-023095-4dannjjm 1669 7 of of IN cord-023095-4dannjjm 1669 8 99 99 CD cord-023095-4dannjjm 1669 9 m m NN cord-023095-4dannjjm 1669 10 Tc Tc NNP cord-023095-4dannjjm 1669 11 - - HYPH cord-023095-4dannjjm 1669 12 labeled label VBN cord-023095-4dannjjm 1669 13 IgG igg NN cord-023095-4dannjjm 1669 14 , , , cord-023095-4dannjjm 1669 15 PEG peg NN cord-023095-4dannjjm 1669 16 - - HYPH cord-023095-4dannjjm 1669 17 liposomes liposome NNS cord-023095-4dannjjm 1669 18 and and CC cord-023095-4dannjjm 1669 19 leukocytes leukocyte NNS cord-023095-4dannjjm 1669 20 in in IN cord-023095-4dannjjm 1669 21 an an DT cord-023095-4dannjjm 1669 22 equine equine JJ cord-023095-4dannjjm 1669 23 muscle muscle NN cord-023095-4dannjjm 1669 24 abscess abscess NN cord-023095-4dannjjm 1669 25 model model NN cord-023095-4dannjjm 1669 26 . . . cord-023095-4dannjjm 1670 1 Three three CD cord-023095-4dannjjm 1670 2 mixed mixed JJ cord-023095-4dannjjm 1670 3 breed breed NN cord-023095-4dannjjm 1670 4 adult adult NN cord-023095-4dannjjm 1670 5 horses horse NNS cord-023095-4dannjjm 1670 6 had have VBD cord-023095-4dannjjm 1670 7 2 2 CD cord-023095-4dannjjm 1670 8 Â â CD cord-023095-4dannjjm 1670 9 10 10 CD cord-023095-4dannjjm 1670 10 6 6 CD cord-023095-4dannjjm 1670 11 CFU CFU NNP cord-023095-4dannjjm 1670 12 S. S. NNP cord-023095-4dannjjm 1670 13 equi equi NN cord-023095-4dannjjm 1670 14 zooepidemicus zooepidemicus NN cord-023095-4dannjjm 1670 15 inoculated inoculate VBN cord-023095-4dannjjm 1670 16 into into IN cord-023095-4dannjjm 1670 17 the the DT cord-023095-4dannjjm 1670 18 right right JJ cord-023095-4dannjjm 1670 19 semitendonosis semitendonosis NN cord-023095-4dannjjm 1670 20 to to TO cord-023095-4dannjjm 1670 21 create create VB cord-023095-4dannjjm 1670 22 an an DT cord-023095-4dannjjm 1670 23 abscess abscess NN cord-023095-4dannjjm 1670 24 . . . cord-023095-4dannjjm 1671 1 PEG peg NN cord-023095-4dannjjm 1671 2 - - HYPH cord-023095-4dannjjm 1671 3 liposomes liposome NNS cord-023095-4dannjjm 1671 4 were be VBD cord-023095-4dannjjm 1671 5 prepared prepare VBN cord-023095-4dannjjm 1671 6 via via IN cord-023095-4dannjjm 1671 7 the the DT cord-023095-4dannjjm 1671 8 film film NN cord-023095-4dannjjm 1671 9 hydration hydration NN cord-023095-4dannjjm 1671 10 method method NN cord-023095-4dannjjm 1671 11 and and CC cord-023095-4dannjjm 1671 12 labeled label VBD cord-023095-4dannjjm 1671 13 using use VBG cord-023095-4dannjjm 1671 14 200 200 CD cord-023095-4dannjjm 1671 15 mCi mCi NNS cord-023095-4dannjjm 1671 16 99 99 CD cord-023095-4dannjjm 1671 17 m m NN cord-023095-4dannjjm 1671 18 Tc Tc NNP cord-023095-4dannjjm 1671 19 - - HYPH cord-023095-4dannjjm 1671 20 hexamethyl hexamethyl JJ cord-023095-4dannjjm 1671 21 - - HYPH cord-023095-4dannjjm 1671 22 propylene propylene NN cord-023095-4dannjjm 1671 23 - - HYPH cord-023095-4dannjjm 1671 24 amine amine NN cord-023095-4dannjjm 1671 25 - - HYPH cord-023095-4dannjjm 1671 26 oxime oxime NN cord-023095-4dannjjm 1671 27 ( ( -LRB- cord-023095-4dannjjm 1671 28 99 99 CD cord-023095-4dannjjm 1671 29 m m NN cord-023095-4dannjjm 1671 30 Tc Tc NNP cord-023095-4dannjjm 1671 31 - - HYPH cord-023095-4dannjjm 1671 32 HMPAO HMPAO NNP cord-023095-4dannjjm 1671 33 ) ) -RRB- cord-023095-4dannjjm 1671 34 . . . cord-023095-4dannjjm 1672 1 Autologous autologous JJ cord-023095-4dannjjm 1672 2 leukocytes leukocyte NNS cord-023095-4dannjjm 1672 3 were be VBD cord-023095-4dannjjm 1672 4 obtained obtain VBN cord-023095-4dannjjm 1672 5 from from IN cord-023095-4dannjjm 1672 6 120 120 CD cord-023095-4dannjjm 1672 7 ml ml NN cord-023095-4dannjjm 1672 8 whole whole JJ cord-023095-4dannjjm 1672 9 blood blood NN cord-023095-4dannjjm 1672 10 and and CC cord-023095-4dannjjm 1672 11 labelled label VBD cord-023095-4dannjjm 1672 12 using use VBG cord-023095-4dannjjm 1672 13 200 200 CD cord-023095-4dannjjm 1672 14 mCi mCi NNS cord-023095-4dannjjm 1672 15 99 99 CD cord-023095-4dannjjm 1672 16 m m NNP cord-023095-4dannjjm 1672 17 Tc Tc NNP cord-023095-4dannjjm 1672 18 - - HYPH cord-023095-4dannjjm 1672 19 HMPAO HMPAO NNP cord-023095-4dannjjm 1672 20 . . . cord-023095-4dannjjm 1673 1 Commercial commercial JJ cord-023095-4dannjjm 1673 2 equine equine JJ cord-023095-4dannjjm 1673 3 polyclonal polyclonal JJ cord-023095-4dannjjm 1673 4 IgG igg NN cord-023095-4dannjjm 1673 5 was be VBD cord-023095-4dannjjm 1673 6 conjugated conjugate VBN cord-023095-4dannjjm 1673 7 with with IN cord-023095-4dannjjm 1673 8 the the DT cord-023095-4dannjjm 1673 9 chelator chelator NN cord-023095-4dannjjm 1673 10 hydrazinonicotinamide hydrazinonicotinamide NN cord-023095-4dannjjm 1673 11 ( ( -LRB- cord-023095-4dannjjm 1673 12 HYNIC HYNIC NNP cord-023095-4dannjjm 1673 13 ) ) -RRB- cord-023095-4dannjjm 1673 14 and and CC cord-023095-4dannjjm 1673 15 labelled label VBN cord-023095-4dannjjm 1673 16 with with IN cord-023095-4dannjjm 1673 17 200 200 CD cord-023095-4dannjjm 1673 18 mCi mCi NNS cord-023095-4dannjjm 1673 19 99 99 CD cord-023095-4dannjjm 1673 20 m m NN cord-023095-4dannjjm 1673 21 Tc Tc NNP cord-023095-4dannjjm 1673 22 . . . cord-023095-4dannjjm 1673 23 Radiopharmaceutical Radiopharmaceutical NNP cord-023095-4dannjjm 1673 24 administration administration NN cord-023095-4dannjjm 1673 25 was be VBD cord-023095-4dannjjm 1673 26 initiated initiate VBN cord-023095-4dannjjm 1673 27 24 24 CD cord-023095-4dannjjm 1673 28 hours hour NNS cord-023095-4dannjjm 1673 29 after after IN cord-023095-4dannjjm 1673 30 inoculation inoculation NN cord-023095-4dannjjm 1673 31 . . . cord-023095-4dannjjm 1674 1 Horses horse NNS cord-023095-4dannjjm 1674 2 1 1 CD cord-023095-4dannjjm 1674 3 and and CC cord-023095-4dannjjm 1674 4 2 2 CD cord-023095-4dannjjm 1674 5 received receive VBD cord-023095-4dannjjm 1674 6 5 5 CD cord-023095-4dannjjm 1674 7 mg mg CD cord-023095-4dannjjm 1674 8 99 99 CD cord-023095-4dannjjm 1674 9 m m NNP cord-023095-4dannjjm 1674 10 Tc Tc NNP cord-023095-4dannjjm 1674 11 - - HYPH cord-023095-4dannjjm 1674 12 IgG IgG NNP cord-023095-4dannjjm 1674 13 , , , cord-023095-4dannjjm 1674 14 2.7 2.7 CD cord-023095-4dannjjm 1674 15 mmol mmol JJ cord-023095-4dannjjm 1674 16 / / SYM cord-023095-4dannjjm 1674 17 kg kg NN cord-023095-4dannjjm 1674 18 99 99 CD cord-023095-4dannjjm 1674 19 m m NNP cord-023095-4dannjjm 1674 20 Tc Tc NNP cord-023095-4dannjjm 1674 21 - - HYPH cord-023095-4dannjjm 1674 22 liposomes liposome NNS cord-023095-4dannjjm 1674 23 and and CC cord-023095-4dannjjm 1674 24 99 99 CD cord-023095-4dannjjm 1674 25 m m NN cord-023095-4dannjjm 1674 26 Tc Tc NNP cord-023095-4dannjjm 1674 27 - - HYPH cord-023095-4dannjjm 1674 28 leukocytes leukocyte NNS cord-023095-4dannjjm 1674 29 , , , cord-023095-4dannjjm 1674 30 with with IN cord-023095-4dannjjm 1674 31 a a DT cord-023095-4dannjjm 1674 32 48 48 CD cord-023095-4dannjjm 1674 33 hour hour NN cord-023095-4dannjjm 1674 34 interval interval NN cord-023095-4dannjjm 1674 35 between between IN cord-023095-4dannjjm 1674 36 each each DT cord-023095-4dannjjm 1674 37 radiopharmaceutical radiopharmaceutical NN cord-023095-4dannjjm 1674 38 . . . cord-023095-4dannjjm 1675 1 Horse horse NN cord-023095-4dannjjm 1675 2 3 3 CD cord-023095-4dannjjm 1675 3 received receive VBD cord-023095-4dannjjm 1675 4 only only RB cord-023095-4dannjjm 1675 5 99 99 CD cord-023095-4dannjjm 1675 6 m m NN cord-023095-4dannjjm 1675 7 Tc Tc NNP cord-023095-4dannjjm 1675 8 - - HYPH cord-023095-4dannjjm 1675 9 leukocytes leukocyte NNS cord-023095-4dannjjm 1675 10 . . . cord-023095-4dannjjm 1676 1 Scintigraphic scintigraphic JJ cord-023095-4dannjjm 1676 2 examinations examination NNS cord-023095-4dannjjm 1676 3 were be VBD cord-023095-4dannjjm 1676 4 performed perform VBN cord-023095-4dannjjm 1676 5 at at IN cord-023095-4dannjjm 1676 6 8 8 CD cord-023095-4dannjjm 1676 7 and and CC cord-023095-4dannjjm 1676 8 21 21 CD cord-023095-4dannjjm 1676 9 hours hour NNS cord-023095-4dannjjm 1676 10 post post NN cord-023095-4dannjjm 1676 11 injection injection NN cord-023095-4dannjjm 1676 12 ( ( -LRB- cord-023095-4dannjjm 1676 13 p.i p.i NNP cord-023095-4dannjjm 1676 14 . . NNP cord-023095-4dannjjm 1676 15 ) ) -RRB- cord-023095-4dannjjm 1676 16 with with IN cord-023095-4dannjjm 1676 17 each each DT cord-023095-4dannjjm 1676 18 radiopharmaceutical radiopharmaceutical NN cord-023095-4dannjjm 1676 19 . . . cord-023095-4dannjjm 1677 1 After after IN cord-023095-4dannjjm 1677 2 the the DT cord-023095-4dannjjm 1677 3 final final JJ cord-023095-4dannjjm 1677 4 study study NN cord-023095-4dannjjm 1677 5 , , , cord-023095-4dannjjm 1677 6 horses horse NNS cord-023095-4dannjjm 1677 7 were be VBD cord-023095-4dannjjm 1677 8 euthanized euthanize VBN cord-023095-4dannjjm 1677 9 and and CC cord-023095-4dannjjm 1677 10 tissue tissue NN cord-023095-4dannjjm 1677 11 samples sample NNS cord-023095-4dannjjm 1677 12 collected collect VBN cord-023095-4dannjjm 1677 13 . . . cord-023095-4dannjjm 1678 1 The the DT cord-023095-4dannjjm 1678 2 percentage percentage NN cord-023095-4dannjjm 1678 3 of of IN cord-023095-4dannjjm 1678 4 injected inject VBN cord-023095-4dannjjm 1678 5 dose dose NN cord-023095-4dannjjm 1678 6 per per IN cord-023095-4dannjjm 1678 7 kilogram kilogram NN cord-023095-4dannjjm 1678 8 of of IN cord-023095-4dannjjm 1678 9 tissue tissue NN cord-023095-4dannjjm 1678 10 ( ( -LRB- cord-023095-4dannjjm 1678 11 % % NN cord-023095-4dannjjm 1678 12 ID ID NNP cord-023095-4dannjjm 1678 13 / / SYM cord-023095-4dannjjm 1678 14 kg kg NNP cord-023095-4dannjjm 1678 15 ) ) -RRB- cord-023095-4dannjjm 1678 16 was be VBD cord-023095-4dannjjm 1678 17 calculated calculate VBN cord-023095-4dannjjm 1678 18 for for IN cord-023095-4dannjjm 1678 19 the the DT cord-023095-4dannjjm 1678 20 region region NN cord-023095-4dannjjm 1678 21 of of IN cord-023095-4dannjjm 1678 22 the the DT cord-023095-4dannjjm 1678 23 abscess abscess NN cord-023095-4dannjjm 1678 24 , , , cord-023095-4dannjjm 1678 25 normal normal JJ cord-023095-4dannjjm 1678 26 muscle muscle NN cord-023095-4dannjjm 1678 27 and and CC cord-023095-4dannjjm 1678 28 multiple multiple JJ cord-023095-4dannjjm 1678 29 organs organ NNS cord-023095-4dannjjm 1678 30 . . . cord-023095-4dannjjm 1679 1 Scintigraphic scintigraphic JJ cord-023095-4dannjjm 1679 2 examinations examination NNS cord-023095-4dannjjm 1679 3 demonstrated demonstrate VBD cord-023095-4dannjjm 1679 4 increased increase VBN cord-023095-4dannjjm 1679 5 radiopharmaceutical radiopharmaceutical NN cord-023095-4dannjjm 1679 6 in in IN cord-023095-4dannjjm 1679 7 the the DT cord-023095-4dannjjm 1679 8 region region NN cord-023095-4dannjjm 1679 9 of of IN cord-023095-4dannjjm 1679 10 the the DT cord-023095-4dannjjm 1679 11 abscess abscess NN cord-023095-4dannjjm 1679 12 with with IN cord-023095-4dannjjm 1679 13 all all DT cord-023095-4dannjjm 1679 14 three three CD cord-023095-4dannjjm 1679 15 techniques technique NNS cord-023095-4dannjjm 1679 16 at at IN cord-023095-4dannjjm 1679 17 both both DT cord-023095-4dannjjm 1679 18 time time NN cord-023095-4dannjjm 1679 19 - - HYPH cord-023095-4dannjjm 1679 20 points point NNS cord-023095-4dannjjm 1679 21 . . . cord-023095-4dannjjm 1680 1 At at IN cord-023095-4dannjjm 1680 2 8 8 CD cord-023095-4dannjjm 1680 3 hours hour NNS cord-023095-4dannjjm 1680 4 p.i p.i NNP cord-023095-4dannjjm 1680 5 . . NNP cord-023095-4dannjjm 1680 6 abscess abscess NN cord-023095-4dannjjm 1680 7 - - HYPH cord-023095-4dannjjm 1680 8 to to IN cord-023095-4dannjjm 1680 9 - - HYPH cord-023095-4dannjjm 1680 10 background background NN cord-023095-4dannjjm 1680 11 ratio ratio NN cord-023095-4dannjjm 1680 12 was be VBD cord-023095-4dannjjm 1680 13 highest highest RBS cord-023095-4dannjjm 1680 14 using use VBG cord-023095-4dannjjm 1680 15 99 99 CD cord-023095-4dannjjm 1680 16 m m NNP cord-023095-4dannjjm 1680 17 Tc Tc NNP cord-023095-4dannjjm 1680 18 - - HYPH cord-023095-4dannjjm 1680 19 IgG IgG NNP cord-023095-4dannjjm 1680 20 ( ( -LRB- cord-023095-4dannjjm 1680 21 3.7 3.7 CD cord-023095-4dannjjm 1680 22 AE AE NNP cord-023095-4dannjjm 1680 23 0.2 0.2 CD cord-023095-4dannjjm 1680 24 ) ) -RRB- cord-023095-4dannjjm 1680 25 . . . cord-023095-4dannjjm 1681 1 At at IN cord-023095-4dannjjm 1681 2 21 21 CD cord-023095-4dannjjm 1681 3 hours hour NNS cord-023095-4dannjjm 1681 4 p.i p.i NNP cord-023095-4dannjjm 1681 5 . . NNP cord-023095-4dannjjm 1681 6 abscess abscess NN cord-023095-4dannjjm 1681 7 to to IN cord-023095-4dannjjm 1681 8 background background NN cord-023095-4dannjjm 1681 9 ratio ratio NN cord-023095-4dannjjm 1681 10 was be VBD cord-023095-4dannjjm 1681 11 highest highest RBS cord-023095-4dannjjm 1681 12 using use VBG cord-023095-4dannjjm 1681 13 99 99 CD cord-023095-4dannjjm 1681 14 m m NNP cord-023095-4dannjjm 1681 15 Tc Tc NNP cord-023095-4dannjjm 1681 16 - - HYPH cord-023095-4dannjjm 1681 17 liposomes liposomes NNP cord-023095-4dannjjm 1681 18 ( ( -LRB- cord-023095-4dannjjm 1681 19 5.9 5.9 CD cord-023095-4dannjjm 1681 20 AE AE NNP cord-023095-4dannjjm 1681 21 2 2 CD cord-023095-4dannjjm 1681 22 ) ) -RRB- cord-023095-4dannjjm 1681 23 . . . cord-023095-4dannjjm 1682 1 Tissue tissue NN cord-023095-4dannjjm 1682 2 biodistribution biodistribution NNP cord-023095-4dannjjm 1682 3 data datum NNS cord-023095-4dannjjm 1682 4 revealed reveal VBD cord-023095-4dannjjm 1682 5 abscess abscess NN cord-023095-4dannjjm 1682 6 to to IN cord-023095-4dannjjm 1682 7 muscle muscle NN cord-023095-4dannjjm 1682 8 ratios ratio NNS cord-023095-4dannjjm 1682 9 of of IN cord-023095-4dannjjm 1682 10 36 36 CD cord-023095-4dannjjm 1682 11 ( ( -LRB- cord-023095-4dannjjm 1682 12 99 99 CD cord-023095-4dannjjm 1682 13 m m NNP cord-023095-4dannjjm 1682 14 Tc Tc NNP cord-023095-4dannjjm 1682 15 - - HYPH cord-023095-4dannjjm 1682 16 IgG IgG NNP cord-023095-4dannjjm 1682 17 ) ) -RRB- cord-023095-4dannjjm 1682 18 , , , cord-023095-4dannjjm 1682 19 24 24 CD cord-023095-4dannjjm 1682 20 ( ( -LRB- cord-023095-4dannjjm 1682 21 99 99 CD cord-023095-4dannjjm 1682 22 m m NN cord-023095-4dannjjm 1682 23 Tc Tc NNP cord-023095-4dannjjm 1682 24 - - HYPH cord-023095-4dannjjm 1682 25 liposomes liposomes NNP cord-023095-4dannjjm 1682 26 ) ) -RRB- cord-023095-4dannjjm 1682 27 , , , cord-023095-4dannjjm 1682 28 and and CC cord-023095-4dannjjm 1682 29 4.1 4.1 CD cord-023095-4dannjjm 1682 30 ( ( -LRB- cord-023095-4dannjjm 1682 31 99 99 CD cord-023095-4dannjjm 1682 32 m m NN cord-023095-4dannjjm 1682 33 Tc Tc NNP cord-023095-4dannjjm 1682 34 - - HYPH cord-023095-4dannjjm 1682 35 leukocytes leukocyte NNS cord-023095-4dannjjm 1682 36 ) ) -RRB- cord-023095-4dannjjm 1682 37 . . . cord-023095-4dannjjm 1683 1 This this DT cord-023095-4dannjjm 1683 2 preliminary preliminary JJ cord-023095-4dannjjm 1683 3 data data NN cord-023095-4dannjjm 1683 4 demonstrates demonstrate VBZ cord-023095-4dannjjm 1683 5 that that IN cord-023095-4dannjjm 1683 6 99 99 CD cord-023095-4dannjjm 1683 7 m m NN cord-023095-4dannjjm 1683 8 Tc tc NN cord-023095-4dannjjm 1683 9 - - HYPH cord-023095-4dannjjm 1683 10 liposomes liposome NNS cord-023095-4dannjjm 1683 11 , , , cord-023095-4dannjjm 1683 12 99 99 CD cord-023095-4dannjjm 1683 13 m m NNP cord-023095-4dannjjm 1683 14 Tc Tc NNP cord-023095-4dannjjm 1683 15 - - HYPH cord-023095-4dannjjm 1683 16 IgG IgG NNP cord-023095-4dannjjm 1683 17 and and CC cord-023095-4dannjjm 1683 18 99 99 CD cord-023095-4dannjjm 1683 19 m m NNP cord-023095-4dannjjm 1683 20 Tc Tc NNP cord-023095-4dannjjm 1683 21 - - HYPH cord-023095-4dannjjm 1683 22 leukocytes leukocyte NNS cord-023095-4dannjjm 1683 23 exhibit exhibit VBP cord-023095-4dannjjm 1683 24 long long RB cord-023095-4dannjjm 1683 25 circulating circulate VBG cord-023095-4dannjjm 1683 26 characteristics characteristic NNS cord-023095-4dannjjm 1683 27 and and CC cord-023095-4dannjjm 1683 28 accumulate accumulate VBP cord-023095-4dannjjm 1683 29 at at IN cord-023095-4dannjjm 1683 30 inflammatory inflammatory JJ cord-023095-4dannjjm 1683 31 / / SYM cord-023095-4dannjjm 1683 32 infectious infectious JJ cord-023095-4dannjjm 1683 33 foci foci NN cord-023095-4dannjjm 1683 34 after after IN cord-023095-4dannjjm 1683 35 intravenous intravenous JJ cord-023095-4dannjjm 1683 36 injection injection NN cord-023095-4dannjjm 1683 37 in in IN cord-023095-4dannjjm 1683 38 horses horse NNS cord-023095-4dannjjm 1683 39 . . . cord-023095-4dannjjm 1684 1 99 99 CD cord-023095-4dannjjm 1684 2 m m NNP cord-023095-4dannjjm 1684 3 Tc Tc NNP cord-023095-4dannjjm 1684 4 - - HYPH cord-023095-4dannjjm 1684 5 IgG IgG NNP cord-023095-4dannjjm 1684 6 and and CC cord-023095-4dannjjm 1684 7 99 99 CD cord-023095-4dannjjm 1684 8 m m NNP cord-023095-4dannjjm 1684 9 Tc Tc NNP cord-023095-4dannjjm 1684 10 - - HYPH cord-023095-4dannjjm 1684 11 liposomes liposome NNS cord-023095-4dannjjm 1684 12 appear appear VBP cord-023095-4dannjjm 1684 13 to to TO cord-023095-4dannjjm 1684 14 be be VB cord-023095-4dannjjm 1684 15 superior superior JJ cord-023095-4dannjjm 1684 16 to to IN cord-023095-4dannjjm 1684 17 99 99 CD cord-023095-4dannjjm 1684 18 m m NN cord-023095-4dannjjm 1684 19 Tc Tc NNP cord-023095-4dannjjm 1684 20 - - HYPH cord-023095-4dannjjm 1684 21 labelled label VBN cord-023095-4dannjjm 1684 22 leukocytes leukocyte NNS cord-023095-4dannjjm 1684 23 in in IN cord-023095-4dannjjm 1684 24 this this DT cord-023095-4dannjjm 1684 25 model model NN cord-023095-4dannjjm 1684 26 . . . cord-023095-4dannjjm 1685 1 Due due IN cord-023095-4dannjjm 1685 2 to to IN cord-023095-4dannjjm 1685 3 its -PRON- PRP$ cord-023095-4dannjjm 1685 4 low low JJ cord-023095-4dannjjm 1685 5 cost cost NN cord-023095-4dannjjm 1685 6 and and CC cord-023095-4dannjjm 1685 7 ease ease NN cord-023095-4dannjjm 1685 8 of of IN cord-023095-4dannjjm 1685 9 preparation preparation NN cord-023095-4dannjjm 1685 10 , , , cord-023095-4dannjjm 1685 11 99 99 CD cord-023095-4dannjjm 1685 12 m m NNP cord-023095-4dannjjm 1685 13 Tc Tc NNP cord-023095-4dannjjm 1685 14 - - HYPH cord-023095-4dannjjm 1685 15 IgG IgG NNP cord-023095-4dannjjm 1685 16 has have VBZ cord-023095-4dannjjm 1685 17 great great JJ cord-023095-4dannjjm 1685 18 potential potential NN cord-023095-4dannjjm 1685 19 for for IN cord-023095-4dannjjm 1685 20 clinical clinical JJ cord-023095-4dannjjm 1685 21 use use NN cord-023095-4dannjjm 1685 22 where where WRB cord-023095-4dannjjm 1685 23 identification identification NN cord-023095-4dannjjm 1685 24 of of IN cord-023095-4dannjjm 1685 25 infectious infectious JJ cord-023095-4dannjjm 1685 26 or or CC cord-023095-4dannjjm 1685 27 inflammatory inflammatory JJ cord-023095-4dannjjm 1685 28 foci foci NN cord-023095-4dannjjm 1685 29 is be VBZ cord-023095-4dannjjm 1685 30 necessary necessary JJ cord-023095-4dannjjm 1685 31 . . . cord-023095-4dannjjm 1686 1 Digital digital JJ cord-023095-4dannjjm 1686 2 hypothermia hypothermia NN cord-023095-4dannjjm 1686 3 is be VBZ cord-023095-4dannjjm 1686 4 used use VBN cord-023095-4dannjjm 1686 5 clinically clinically RB cord-023095-4dannjjm 1686 6 to to TO cord-023095-4dannjjm 1686 7 decrease decrease VB cord-023095-4dannjjm 1686 8 the the DT cord-023095-4dannjjm 1686 9 incidence incidence NN cord-023095-4dannjjm 1686 10 of of IN cord-023095-4dannjjm 1686 11 sepsis sepsis NN cord-023095-4dannjjm 1686 12 - - HYPH cord-023095-4dannjjm 1686 13 related relate VBN cord-023095-4dannjjm 1686 14 equine equine NN cord-023095-4dannjjm 1686 15 laminitis laminitis NN cord-023095-4dannjjm 1686 16 , , , cord-023095-4dannjjm 1686 17 a a DT cord-023095-4dannjjm 1686 18 disease disease NN cord-023095-4dannjjm 1686 19 causing cause VBG cord-023095-4dannjjm 1686 20 structural structural JJ cord-023095-4dannjjm 1686 21 failure failure NN cord-023095-4dannjjm 1686 22 of of IN cord-023095-4dannjjm 1686 23 digital digital JJ cord-023095-4dannjjm 1686 24 laminae laminae NNP cord-023095-4dannjjm 1686 25 resulting result VBG cord-023095-4dannjjm 1686 26 in in IN cord-023095-4dannjjm 1686 27 crippling crippling JJ cord-023095-4dannjjm 1686 28 lameness lameness NN cord-023095-4dannjjm 1686 29 . . . cord-023095-4dannjjm 1687 1 Due due IN cord-023095-4dannjjm 1687 2 to to IN cord-023095-4dannjjm 1687 3 the the DT cord-023095-4dannjjm 1687 4 fact fact NN cord-023095-4dannjjm 1687 5 that that IN cord-023095-4dannjjm 1687 6 hypothermia hypothermia NN cord-023095-4dannjjm 1687 7 was be VBD cord-023095-4dannjjm 1687 8 recently recently RB cord-023095-4dannjjm 1687 9 reported report VBN cord-023095-4dannjjm 1687 10 to to TO cord-023095-4dannjjm 1687 11 effectively effectively RB cord-023095-4dannjjm 1687 12 decrease decrease VB cord-023095-4dannjjm 1687 13 laminar laminar JJ cord-023095-4dannjjm 1687 14 expression expression NN cord-023095-4dannjjm 1687 15 of of IN cord-023095-4dannjjm 1687 16 inflammatory inflammatory JJ cord-023095-4dannjjm 1687 17 molecules molecule NNS cord-023095-4dannjjm 1687 18 including include VBG cord-023095-4dannjjm 1687 19 pro pro JJ cord-023095-4dannjjm 1687 20 - - JJ cord-023095-4dannjjm 1687 21 inflammatory inflammatory JJ cord-023095-4dannjjm 1687 22 cytokines cytokine NNS cord-023095-4dannjjm 1687 23 , , , cord-023095-4dannjjm 1687 24 chemokines chemokine NNS cord-023095-4dannjjm 1687 25 and and CC cord-023095-4dannjjm 1687 26 COX-2 COX-2 NNP cord-023095-4dannjjm 1687 27 in in IN cord-023095-4dannjjm 1687 28 equine equine JJ cord-023095-4dannjjm 1687 29 laminitis laminitis NN cord-023095-4dannjjm 1687 30 , , , cord-023095-4dannjjm 1687 31 our -PRON- PRP$ cord-023095-4dannjjm 1687 32 laboratory laboratory NN cord-023095-4dannjjm 1687 33 is be VBZ cord-023095-4dannjjm 1687 34 investigating investigate VBG cord-023095-4dannjjm 1687 35 the the DT cord-023095-4dannjjm 1687 36 effect effect NN cord-023095-4dannjjm 1687 37 of of IN cord-023095-4dannjjm 1687 38 hypothermia hypothermia NN cord-023095-4dannjjm 1687 39 on on IN cord-023095-4dannjjm 1687 40 central central JJ cord-023095-4dannjjm 1687 41 upstream upstream RB cord-023095-4dannjjm 1687 42 signaling signal VBG cord-023095-4dannjjm 1687 43 cascades cascade NNS cord-023095-4dannjjm 1687 44 which which WDT cord-023095-4dannjjm 1687 45 may may MD cord-023095-4dannjjm 1687 46 induce induce VB cord-023095-4dannjjm 1687 47 expression expression NN cord-023095-4dannjjm 1687 48 of of IN cord-023095-4dannjjm 1687 49 these these DT cord-023095-4dannjjm 1687 50 diverse diverse JJ cord-023095-4dannjjm 1687 51 inflammatory inflammatory JJ cord-023095-4dannjjm 1687 52 molecules molecule NNS cord-023095-4dannjjm 1687 53 . . . cord-023095-4dannjjm 1688 1 The the DT cord-023095-4dannjjm 1688 2 p38 p38 CD cord-023095-4dannjjm 1688 3 MAPK MAPK NNP cord-023095-4dannjjm 1688 4 pathway pathway NN cord-023095-4dannjjm 1688 5 has have VBZ cord-023095-4dannjjm 1688 6 recently recently RB cord-023095-4dannjjm 1688 7 been be VBN cord-023095-4dannjjm 1688 8 reported report VBN cord-023095-4dannjjm 1688 9 to to TO cord-023095-4dannjjm 1688 10 be be VB cord-023095-4dannjjm 1688 11 a a DT cord-023095-4dannjjm 1688 12 central central JJ cord-023095-4dannjjm 1688 13 component component NN cord-023095-4dannjjm 1688 14 of of IN cord-023095-4dannjjm 1688 15 inflammatory inflammatory JJ cord-023095-4dannjjm 1688 16 signaling signaling NN cord-023095-4dannjjm 1688 17 in in IN cord-023095-4dannjjm 1688 18 multiple multiple JJ cord-023095-4dannjjm 1688 19 diseases disease NNS cord-023095-4dannjjm 1688 20 including include VBG cord-023095-4dannjjm 1688 21 human human JJ cord-023095-4dannjjm 1688 22 sepsis sepsis NN cord-023095-4dannjjm 1688 23 , , , cord-023095-4dannjjm 1688 24 and and CC cord-023095-4dannjjm 1688 25 is be VBZ cord-023095-4dannjjm 1688 26 currently currently RB cord-023095-4dannjjm 1688 27 being be VBG cord-023095-4dannjjm 1688 28 assessed assess VBN cord-023095-4dannjjm 1688 29 as as IN cord-023095-4dannjjm 1688 30 a a DT cord-023095-4dannjjm 1688 31 therapeutic therapeutic JJ cord-023095-4dannjjm 1688 32 target target NN cord-023095-4dannjjm 1688 33 . . . cord-023095-4dannjjm 1689 1 We -PRON- PRP cord-023095-4dannjjm 1689 2 thus thus RB cord-023095-4dannjjm 1689 3 hypothesized hypothesize VBD cord-023095-4dannjjm 1689 4 that that IN cord-023095-4dannjjm 1689 5 1 1 CD cord-023095-4dannjjm 1689 6 ) ) -RRB- cord-023095-4dannjjm 1689 7 p38 p38 CD cord-023095-4dannjjm 1689 8 MAPK MAPK NNP cord-023095-4dannjjm 1689 9 is be VBZ cord-023095-4dannjjm 1689 10 upregulated upregulate VBN cord-023095-4dannjjm 1689 11 and and CC cord-023095-4dannjjm 1689 12 activated activate VBN cord-023095-4dannjjm 1689 13 in in IN cord-023095-4dannjjm 1689 14 affected affect VBN cord-023095-4dannjjm 1689 15 laminae laminae RB cord-023095-4dannjjm 1689 16 in in IN cord-023095-4dannjjm 1689 17 equine equine JJ cord-023095-4dannjjm 1689 18 laminitis laminitis NN cord-023095-4dannjjm 1689 19 and and CC cord-023095-4dannjjm 1689 20 2 2 CD cord-023095-4dannjjm 1689 21 ) ) -RRB- cord-023095-4dannjjm 1690 1 digital digital JJ cord-023095-4dannjjm 1690 2 hypothermia hypothermia NN cord-023095-4dannjjm 1690 3 inhibits inhibit VBZ cord-023095-4dannjjm 1690 4 inflammatory inflammatory JJ cord-023095-4dannjjm 1690 5 mediator mediator NN cord-023095-4dannjjm 1690 6 expression expression NN cord-023095-4dannjjm 1690 7 by by IN cord-023095-4dannjjm 1690 8 blocking block VBG cord-023095-4dannjjm 1690 9 p38 p38 CD cord-023095-4dannjjm 1690 10 MAPK MAPK NNP cord-023095-4dannjjm 1690 11 phosphorylation phosphorylation NN cord-023095-4dannjjm 1690 12 ( ( -LRB- cord-023095-4dannjjm 1690 13 indicator indicator NN cord-023095-4dannjjm 1690 14 of of IN cord-023095-4dannjjm 1690 15 p38 p38 NNP cord-023095-4dannjjm 1690 16 MAPK MAPK NNP cord-023095-4dannjjm 1690 17 activation activation NN cord-023095-4dannjjm 1690 18 ) ) -RRB- cord-023095-4dannjjm 1690 19 . . . cord-023095-4dannjjm 1691 1 Western western JJ cord-023095-4dannjjm 1691 2 hybridizations hybridization NNS cord-023095-4dannjjm 1691 3 using use VBG cord-023095-4dannjjm 1691 4 both both CC cord-023095-4dannjjm 1691 5 a a DT cord-023095-4dannjjm 1691 6 total total JJ cord-023095-4dannjjm 1691 7 p38 p38 CD cord-023095-4dannjjm 1691 8 MAPK MAPK NNP cord-023095-4dannjjm 1691 9 and and CC cord-023095-4dannjjm 1691 10 a a DT cord-023095-4dannjjm 1691 11 phospho phospho NN cord-023095-4dannjjm 1691 12 - - HYPH cord-023095-4dannjjm 1691 13 p38 p38 CD cord-023095-4dannjjm 1691 14 MAPK MAPK NNP cord-023095-4dannjjm 1691 15 antibody antibody NN cord-023095-4dannjjm 1691 16 were be VBD cord-023095-4dannjjm 1691 17 performed perform VBN cord-023095-4dannjjm 1691 18 on on IN cord-023095-4dannjjm 1691 19 archived archived JJ cord-023095-4dannjjm 1691 20 pooled pool VBN cord-023095-4dannjjm 1691 21 laminar laminar JJ cord-023095-4dannjjm 1691 22 samples sample NNS cord-023095-4dannjjm 1691 23 from from IN cord-023095-4dannjjm 1691 24 black black JJ cord-023095-4dannjjm 1691 25 walnut walnut NN cord-023095-4dannjjm 1691 26 extract extract NN cord-023095-4dannjjm 1691 27 ( ( -LRB- cord-023095-4dannjjm 1691 28 BWE BWE NNP cord-023095-4dannjjm 1691 29 ) ) -RRB- cord-023095-4dannjjm 1691 30 model model NN cord-023095-4dannjjm 1691 31 ( ( -LRB- cord-023095-4dannjjm 1691 32 10 10 CD cord-023095-4dannjjm 1691 33 control control NN cord-023095-4dannjjm 1691 34 , , , cord-023095-4dannjjm 1691 35 2 2 CD cord-023095-4dannjjm 1691 36 developmental developmental JJ cord-023095-4dannjjm 1691 37 ( ( -LRB- cord-023095-4dannjjm 1691 38 DEV dev NN cord-023095-4dannjjm 1691 39 ) ) -RRB- cord-023095-4dannjjm 1691 40 groups group NNS cord-023095-4dannjjm 1691 41 [ [ -LRB- cord-023095-4dannjjm 1691 42 1.5H 1.5H NNP cord-023095-4dannjjm 1691 43 & & CC cord-023095-4dannjjm 1691 44 3H 3H NNP cord-023095-4dannjjm 1691 45 post post NNP cord-023095-4dannjjm 1691 46 BWE BWE NNP cord-023095-4dannjjm 1691 47 administration administration NN cord-023095-4dannjjm 1691 48 ] ] -RRB- cord-023095-4dannjjm 1691 49 and and CC cord-023095-4dannjjm 1691 50 the the DT cord-023095-4dannjjm 1691 51 onset onset NN cord-023095-4dannjjm 1691 52 of of IN cord-023095-4dannjjm 1691 53 Obel Obel NNP cord-023095-4dannjjm 1691 54 Grade Grade NNP cord-023095-4dannjjm 1691 55 1 1 CD cord-023095-4dannjjm 1691 56 lameness lameness NN cord-023095-4dannjjm 1691 57 ( ( -LRB- cord-023095-4dannjjm 1691 58 OG1 OG1 NNP cord-023095-4dannjjm 1691 59 ) ) -RRB- cord-023095-4dannjjm 1691 60 [ [ -LRB- cord-023095-4dannjjm 1691 61 n n NN cord-023095-4dannjjm 1691 62 5 5 CD cord-023095-4dannjjm 1691 63 5 5 CD cord-023095-4dannjjm 1691 64 each each DT cord-023095-4dannjjm 1691 65 ] ] -RRB- cord-023095-4dannjjm 1691 66 ) ) -RRB- cord-023095-4dannjjm 1691 67 and and CC cord-023095-4dannjjm 1691 68 carbohydrate carbohydrate NN cord-023095-4dannjjm 1691 69 overload overload NN cord-023095-4dannjjm 1691 70 ( ( -LRB- cord-023095-4dannjjm 1691 71 CHO CHO NNP cord-023095-4dannjjm 1691 72 ) ) -RRB- cord-023095-4dannjjm 1691 73 models model NNS cord-023095-4dannjjm 1691 74 ( ( -LRB- cord-023095-4dannjjm 1691 75 CON con NN cord-023095-4dannjjm 1691 76 [ [ -LRB- cord-023095-4dannjjm 1691 77 n n NN cord-023095-4dannjjm 1691 78 5 5 CD cord-023095-4dannjjm 1691 79 8 8 CD cord-023095-4dannjjm 1691 80 ] ] -RRB- cord-023095-4dannjjm 1691 81 , , , cord-023095-4dannjjm 1691 82 DEV DEV NNP cord-023095-4dannjjm 1691 83 [ [ -LRB- cord-023095-4dannjjm 1691 84 n n NN cord-023095-4dannjjm 1691 85 5 5 CD cord-023095-4dannjjm 1691 86 6 6 CD cord-023095-4dannjjm 1691 87 ] ] -RRB- cord-023095-4dannjjm 1691 88 , , , cord-023095-4dannjjm 1691 89 OG1[n OG1[n NNP cord-023095-4dannjjm 1691 90 5 5 CD cord-023095-4dannjjm 1691 91 6 6 CD cord-023095-4dannjjm 1691 92 ] ] -RRB- cord-023095-4dannjjm 1691 93 ) ) -RRB- cord-023095-4dannjjm 1691 94 of of IN cord-023095-4dannjjm 1691 95 laminitis laminitis NN cord-023095-4dannjjm 1691 96 , , , cord-023095-4dannjjm 1691 97 and and CC cord-023095-4dannjjm 1691 98 individual individual JJ cord-023095-4dannjjm 1691 99 laminar laminar JJ cord-023095-4dannjjm 1691 100 samples sample NNS cord-023095-4dannjjm 1691 101 from from IN cord-023095-4dannjjm 1691 102 two two CD cord-023095-4dannjjm 1691 103 groups group NNS cord-023095-4dannjjm 1691 104 of of IN cord-023095-4dannjjm 1691 105 horses horse NNS cord-023095-4dannjjm 1691 106 from from IN cord-023095-4dannjjm 1691 107 a a DT cord-023095-4dannjjm 1691 108 digital digital JJ cord-023095-4dannjjm 1691 109 hypothermia hypothermia NN cord-023095-4dannjjm 1691 110 ( ( -LRB- cord-023095-4dannjjm 1691 111 DH DH NNP cord-023095-4dannjjm 1691 112 ) ) -RRB- cord-023095-4dannjjm 1691 113 study study NN cord-023095-4dannjjm 1691 114 . . . cord-023095-4dannjjm 1692 1 In in IN cord-023095-4dannjjm 1692 2 the the DT cord-023095-4dannjjm 1692 3 DH DH NNP cord-023095-4dannjjm 1692 4 study study NN cord-023095-4dannjjm 1692 5 , , , cord-023095-4dannjjm 1692 6 one one CD cord-023095-4dannjjm 1692 7 forelimb forelimb NN cord-023095-4dannjjm 1692 8 of of IN cord-023095-4dannjjm 1692 9 each each DT cord-023095-4dannjjm 1692 10 horse horse NN cord-023095-4dannjjm 1692 11 was be VBD cord-023095-4dannjjm 1692 12 kept keep VBN cord-023095-4dannjjm 1692 13 at at IN cord-023095-4dannjjm 1692 14 approximately approximately RB cord-023095-4dannjjm 1692 15 41C 41c CD cord-023095-4dannjjm 1692 16 in in IN cord-023095-4dannjjm 1692 17 ice ice NN cord-023095-4dannjjm 1692 18 water water NN cord-023095-4dannjjm 1692 19 and and CC cord-023095-4dannjjm 1692 20 the the DT cord-023095-4dannjjm 1692 21 other other JJ cord-023095-4dannjjm 1692 22 at at IN cord-023095-4dannjjm 1692 23 ambient ambient JJ cord-023095-4dannjjm 1692 24 temperature temperature NN cord-023095-4dannjjm 1692 25 following follow VBG cord-023095-4dannjjm 1692 26 administration administration NN cord-023095-4dannjjm 1692 27 of of IN cord-023095-4dannjjm 1692 28 10 10 CD cord-023095-4dannjjm 1692 29 g g NN cord-023095-4dannjjm 1692 30 / / SYM cord-023095-4dannjjm 1692 31 kg kg NNP cord-023095-4dannjjm 1692 32 oligofructose oligofructose RB cord-023095-4dannjjm 1693 1 ( ( -LRB- cord-023095-4dannjjm 1693 2 OF of NN cord-023095-4dannjjm 1693 3 ) ) -RRB- cord-023095-4dannjjm 1693 4 . . . cord-023095-4dannjjm 1694 1 Dorsal dorsal JJ cord-023095-4dannjjm 1694 2 laminae laminae RB cord-023095-4dannjjm 1694 3 were be VBD cord-023095-4dannjjm 1694 4 harvested harvest VBN cord-023095-4dannjjm 1694 5 for for IN cord-023095-4dannjjm 1694 6 snap snap JJ cord-023095-4dannjjm 1694 7 freezing freezing NN cord-023095-4dannjjm 1694 8 at at IN cord-023095-4dannjjm 1694 9 either either CC cord-023095-4dannjjm 1694 10 24 24 CD cord-023095-4dannjjm 1694 11 hours hour NNS cord-023095-4dannjjm 1694 12 after after IN cord-023095-4dannjjm 1694 13 OF of IN cord-023095-4dannjjm 1694 14 administration administration NN cord-023095-4dannjjm 1694 15 ( ( -LRB- cord-023095-4dannjjm 1694 16 DEV DEV NNP cord-023095-4dannjjm 1694 17 , , , cord-023095-4dannjjm 1694 18 n n NN cord-023095-4dannjjm 1694 19 5 5 CD cord-023095-4dannjjm 1694 20 7 7 CD cord-023095-4dannjjm 1694 21 ) ) -RRB- cord-023095-4dannjjm 1694 22 or or CC cord-023095-4dannjjm 1694 23 at at IN cord-023095-4dannjjm 1694 24 the the DT cord-023095-4dannjjm 1694 25 onset onset NN cord-023095-4dannjjm 1694 26 of of IN cord-023095-4dannjjm 1694 27 lameness lameness NN cord-023095-4dannjjm 1694 28 ( ( -LRB- cord-023095-4dannjjm 1694 29 OG1 OG1 NNP cord-023095-4dannjjm 1694 30 , , , cord-023095-4dannjjm 1694 31 n n NN cord-023095-4dannjjm 1694 32 5 5 CD cord-023095-4dannjjm 1694 33 6 6 CD cord-023095-4dannjjm 1694 34 ) ) -RRB- cord-023095-4dannjjm 1694 35 using use VBG cord-023095-4dannjjm 1694 36 protein protein NN cord-023095-4dannjjm 1694 37 extracted extract VBN cord-023095-4dannjjm 1694 38 from from IN cord-023095-4dannjjm 1694 39 treated treat VBN cord-023095-4dannjjm 1694 40 and and CC cord-023095-4dannjjm 1694 41 untreated untreated JJ cord-023095-4dannjjm 1694 42 digital digital JJ cord-023095-4dannjjm 1694 43 laminae laminae NN cord-023095-4dannjjm 1694 44 of of IN cord-023095-4dannjjm 1694 45 each each DT cord-023095-4dannjjm 1694 46 horse horse NN cord-023095-4dannjjm 1694 47 . . . cord-023095-4dannjjm 1695 1 Increased increase VBN cord-023095-4dannjjm 1695 2 laminar laminar JJ cord-023095-4dannjjm 1695 3 concentrations concentration NNS cord-023095-4dannjjm 1695 4 of of IN cord-023095-4dannjjm 1695 5 phospho phospho NN cord-023095-4dannjjm 1695 6 - - HYPH cord-023095-4dannjjm 1695 7 p38 p38 JJ cord-023095-4dannjjm 1695 8 MAPK MAPK NNP cord-023095-4dannjjm 1695 9 were be VBD cord-023095-4dannjjm 1695 10 present present JJ cord-023095-4dannjjm 1695 11 in in IN cord-023095-4dannjjm 1695 12 the the DT cord-023095-4dannjjm 1695 13 developmental developmental JJ cord-023095-4dannjjm 1695 14 periods period NNS cord-023095-4dannjjm 1695 15 ( ( -LRB- cord-023095-4dannjjm 1695 16 1.5H 1.5h NN cord-023095-4dannjjm 1695 17 and and CC cord-023095-4dannjjm 1695 18 3H 3H NNP cord-023095-4dannjjm 1695 19 ) ) -RRB- cord-023095-4dannjjm 1695 20 in in IN cord-023095-4dannjjm 1695 21 the the DT cord-023095-4dannjjm 1695 22 BWE BWE NNP cord-023095-4dannjjm 1695 23 model model NN cord-023095-4dannjjm 1695 24 , , , cord-023095-4dannjjm 1695 25 and and CC cord-023095-4dannjjm 1695 26 in in IN cord-023095-4dannjjm 1695 27 both both CC cord-023095-4dannjjm 1695 28 the the DT cord-023095-4dannjjm 1695 29 DEV DEV NNP cord-023095-4dannjjm 1695 30 and and CC cord-023095-4dannjjm 1695 31 OG1 OG1 VBN cord-023095-4dannjjm 1695 32 periods period NNS cord-023095-4dannjjm 1695 33 in in IN cord-023095-4dannjjm 1695 34 the the DT cord-023095-4dannjjm 1695 35 CHO CHO NNP cord-023095-4dannjjm 1695 36 laminitis laminitis NN cord-023095-4dannjjm 1695 37 models model NNS cord-023095-4dannjjm 1695 38 . . . cord-023095-4dannjjm 1696 1 However however RB cord-023095-4dannjjm 1696 2 , , , cord-023095-4dannjjm 1696 3 digital digital JJ cord-023095-4dannjjm 1696 4 hypothermia hypothermia NN cord-023095-4dannjjm 1696 5 had have VBD cord-023095-4dannjjm 1696 6 no no DT cord-023095-4dannjjm 1696 7 effect effect NN cord-023095-4dannjjm 1696 8 on on IN cord-023095-4dannjjm 1696 9 laminar laminar JJ cord-023095-4dannjjm 1696 10 phospho phospho JJ cord-023095-4dannjjm 1696 11 - - HYPH cord-023095-4dannjjm 1696 12 p38 p38 CD cord-023095-4dannjjm 1696 13 MAPK MAPK NNP cord-023095-4dannjjm 1696 14 concentrations concentration NNS cord-023095-4dannjjm 1696 15 . . . cord-023095-4dannjjm 1697 1 Thus thus RB cord-023095-4dannjjm 1697 2 , , , cord-023095-4dannjjm 1697 3 p38 p38 JJ cord-023095-4dannjjm 1697 4 MAPK MAPK NNP cord-023095-4dannjjm 1697 5 is be VBZ cord-023095-4dannjjm 1697 6 activated activate VBN cord-023095-4dannjjm 1697 7 in in IN cord-023095-4dannjjm 1697 8 affected affect VBN cord-023095-4dannjjm 1697 9 laminae laminae RB cord-023095-4dannjjm 1697 10 in in IN cord-023095-4dannjjm 1697 11 multiple multiple JJ cord-023095-4dannjjm 1697 12 models model NNS cord-023095-4dannjjm 1697 13 of of IN cord-023095-4dannjjm 1697 14 laminitis laminitis NN cord-023095-4dannjjm 1697 15 , , , cord-023095-4dannjjm 1697 16 but but CC cord-023095-4dannjjm 1697 17 does do VBZ cord-023095-4dannjjm 1697 18 not not RB cord-023095-4dannjjm 1697 19 appear appear VB cord-023095-4dannjjm 1697 20 to to TO cord-023095-4dannjjm 1697 21 be be VB cord-023095-4dannjjm 1697 22 the the DT cord-023095-4dannjjm 1697 23 central central JJ cord-023095-4dannjjm 1697 24 signaling signal VBG cord-023095-4dannjjm 1697 25 cascade cascade NN cord-023095-4dannjjm 1697 26 through through IN cord-023095-4dannjjm 1697 27 which which WDT cord-023095-4dannjjm 1697 28 hypothermia hypothermia NN cord-023095-4dannjjm 1697 29 works work VBZ cord-023095-4dannjjm 1697 30 to to TO cord-023095-4dannjjm 1697 31 block block VB cord-023095-4dannjjm 1697 32 the the DT cord-023095-4dannjjm 1697 33 expression expression NN cord-023095-4dannjjm 1697 34 of of IN cord-023095-4dannjjm 1697 35 inflammatory inflammatory JJ cord-023095-4dannjjm 1697 36 molecules molecule NNS cord-023095-4dannjjm 1697 37 . . . cord-023095-4dannjjm 1698 1 Therefore therefore RB cord-023095-4dannjjm 1698 2 , , , cord-023095-4dannjjm 1698 3 p38 p38 JJ cord-023095-4dannjjm 1698 4 MAPK MAPK NNP cord-023095-4dannjjm 1698 5 is be VBZ cord-023095-4dannjjm 1698 6 not not RB cord-023095-4dannjjm 1698 7 likely likely JJ cord-023095-4dannjjm 1698 8 to to TO cord-023095-4dannjjm 1698 9 be be VB cord-023095-4dannjjm 1698 10 a a DT cord-023095-4dannjjm 1698 11 viable viable JJ cord-023095-4dannjjm 1698 12 therapeutic therapeutic JJ cord-023095-4dannjjm 1698 13 target target NN cord-023095-4dannjjm 1698 14 as as IN cord-023095-4dannjjm 1698 15 a a DT cord-023095-4dannjjm 1698 16 sole sole JJ cord-023095-4dannjjm 1698 17 source source NN cord-023095-4dannjjm 1698 18 for for IN cord-023095-4dannjjm 1698 19 blocking block VBG cord-023095-4dannjjm 1698 20 the the DT cord-023095-4dannjjm 1698 21 multiple multiple JJ cord-023095-4dannjjm 1698 22 inflammatory inflammatory JJ cord-023095-4dannjjm 1698 23 signaling signaling NN cord-023095-4dannjjm 1698 24 mechanisms mechanism NNS cord-023095-4dannjjm 1698 25 inhibited inhibit VBN cord-023095-4dannjjm 1698 26 by by IN cord-023095-4dannjjm 1698 27 local local JJ cord-023095-4dannjjm 1698 28 hypothermia hypothermia NN cord-023095-4dannjjm 1698 29 . . . cord-023095-4dannjjm 1699 1 ABSTRACT ABSTRACT NNP cord-023095-4dannjjm 1699 2 E-60 E-60 NNP cord-023095-4dannjjm 1699 3 DOES do VBZ cord-023095-4dannjjm 1699 4 CEFQUINOME CEFQUINOME NNP cord-023095-4dannjjm 1699 5 PENETRATE penetrate VB cord-023095-4dannjjm 1699 6 THE the DT cord-023095-4dannjjm 1699 7 BLOOD blood NN cord-023095-4dannjjm 1699 8 BRAIN brain NN cord-023095-4dannjjm 1699 9 BARRIER barrier NN cord-023095-4dannjjm 1699 10 IN in IN cord-023095-4dannjjm 1699 11 THE the DT cord-023095-4dannjjm 1699 12 NORMAL normal JJ cord-023095-4dannjjm 1699 13 HORSE horse NN cord-023095-4dannjjm 1699 14 ? ? . cord-023095-4dannjjm 1700 1 Hollis Hollis NNP cord-023095-4dannjjm 1700 2 AR AR NNP cord-023095-4dannjjm 1700 3 1 1 CD cord-023095-4dannjjm 1700 4 Duggan Duggan NNP cord-023095-4dannjjm 1700 5 VE VE NNP cord-023095-4dannjjm 1700 6 2 2 CD cord-023095-4dannjjm 1700 7 and and CC cord-023095-4dannjjm 1700 8 Corley Corley NNP cord-023095-4dannjjm 1700 9 KTT KTT NNP cord-023095-4dannjjm 1700 10 3 3 CD cord-023095-4dannjjm 1700 11 . . . cord-023095-4dannjjm 1700 12 1 1 CD cord-023095-4dannjjm 1701 1 Scott Scott NNP cord-023095-4dannjjm 1701 2 Dunn Dunn NNP cord-023095-4dannjjm 1701 3 's 's POS cord-023095-4dannjjm 1701 4 Equine Equine NNP cord-023095-4dannjjm 1701 5 Clinic Clinic NNP cord-023095-4dannjjm 1701 6 , , , cord-023095-4dannjjm 1701 7 Berkshire Berkshire NNP cord-023095-4dannjjm 1701 8 , , , cord-023095-4dannjjm 1701 9 UK UK NNP cord-023095-4dannjjm 1701 10 ; ; : cord-023095-4dannjjm 1701 11 2 2 CD cord-023095-4dannjjm 1701 12 University University NNP cord-023095-4dannjjm 1701 13 College College NNP cord-023095-4dannjjm 1701 14 Dublin Dublin NNP cord-023095-4dannjjm 1701 15 , , , cord-023095-4dannjjm 1701 16 Dublin Dublin NNP cord-023095-4dannjjm 1701 17 , , , cord-023095-4dannjjm 1701 18 Ireland Ireland NNP cord-023095-4dannjjm 1701 19 ; ; : cord-023095-4dannjjm 1701 20 3 3 CD cord-023095-4dannjjm 1701 21 Anglesey Anglesey NNP cord-023095-4dannjjm 1701 22 Lodge Lodge NNP cord-023095-4dannjjm 1701 23 Equine Equine NNP cord-023095-4dannjjm 1701 24 Hospital Hospital NNP cord-023095-4dannjjm 1701 25 , , , cord-023095-4dannjjm 1701 26 The the DT cord-023095-4dannjjm 1701 27 Curragh Curragh NNP cord-023095-4dannjjm 1701 28 , , , cord-023095-4dannjjm 1701 29 Ireland Ireland NNP cord-023095-4dannjjm 1701 30 . . . cord-023095-4dannjjm 1702 1 Meningitis meningitis NN cord-023095-4dannjjm 1702 2 is be VBZ cord-023095-4dannjjm 1702 3 a a DT cord-023095-4dannjjm 1702 4 rare rare JJ cord-023095-4dannjjm 1702 5 but but CC cord-023095-4dannjjm 1702 6 serious serious JJ cord-023095-4dannjjm 1702 7 condition condition NN cord-023095-4dannjjm 1702 8 that that WDT cord-023095-4dannjjm 1702 9 occurs occur VBZ cord-023095-4dannjjm 1702 10 in in IN cord-023095-4dannjjm 1702 11 both both DT cord-023095-4dannjjm 1702 12 foals foal NNS cord-023095-4dannjjm 1702 13 and and CC cord-023095-4dannjjm 1702 14 adult adult NN cord-023095-4dannjjm 1702 15 horses horse NNS cord-023095-4dannjjm 1702 16 . . . cord-023095-4dannjjm 1703 1 There there EX cord-023095-4dannjjm 1703 2 is be VBZ cord-023095-4dannjjm 1703 3 currently currently RB cord-023095-4dannjjm 1703 4 a a DT cord-023095-4dannjjm 1703 5 restricted restricted JJ cord-023095-4dannjjm 1703 6 choice choice NN cord-023095-4dannjjm 1703 7 of of IN cord-023095-4dannjjm 1703 8 antimicrobials antimicrobial NNS cord-023095-4dannjjm 1703 9 that that WDT cord-023095-4dannjjm 1703 10 are be VBP cord-023095-4dannjjm 1703 11 both both RB cord-023095-4dannjjm 1703 12 safe safe JJ cord-023095-4dannjjm 1703 13 to to TO cord-023095-4dannjjm 1703 14 use use VB cord-023095-4dannjjm 1703 15 in in IN cord-023095-4dannjjm 1703 16 horses horse NNS cord-023095-4dannjjm 1703 17 and and CC cord-023095-4dannjjm 1703 18 penetrate penetrate VB cord-023095-4dannjjm 1703 19 the the DT cord-023095-4dannjjm 1703 20 blood blood NN cord-023095-4dannjjm 1703 21 brain brain NN cord-023095-4dannjjm 1703 22 barrier barrier NN cord-023095-4dannjjm 1703 23 . . . cord-023095-4dannjjm 1704 1 Cefquinome Cefquinome NNP cord-023095-4dannjjm 1704 2 is be VBZ cord-023095-4dannjjm 1704 3 a a DT cord-023095-4dannjjm 1704 4 fourth fourth JJ cord-023095-4dannjjm 1704 5 generation generation NN cord-023095-4dannjjm 1704 6 cephalosporin cephalosporin NN cord-023095-4dannjjm 1704 7 that that WDT cord-023095-4dannjjm 1704 8 has have VBZ cord-023095-4dannjjm 1704 9 activity activity NN cord-023095-4dannjjm 1704 10 against against IN cord-023095-4dannjjm 1704 11 Streptococcus Streptococcus NNP cord-023095-4dannjjm 1704 12 , , , cord-023095-4dannjjm 1704 13 the the DT cord-023095-4dannjjm 1704 14 most most RBS cord-023095-4dannjjm 1704 15 commonly commonly RB cord-023095-4dannjjm 1704 16 reported report VBN cord-023095-4dannjjm 1704 17 causative causative JJ cord-023095-4dannjjm 1704 18 organism organism NN cord-023095-4dannjjm 1704 19 in in IN cord-023095-4dannjjm 1704 20 adult adult NN cord-023095-4dannjjm 1704 21 horse horse NN cord-023095-4dannjjm 1704 22 meningitis meningitis NN cord-023095-4dannjjm 1704 23 . . . cord-023095-4dannjjm 1705 1 Therefore therefore RB cord-023095-4dannjjm 1705 2 , , , cord-023095-4dannjjm 1705 3 if if IN cord-023095-4dannjjm 1705 4 cefquinome cefquinome NNP cord-023095-4dannjjm 1705 5 were be VBD cord-023095-4dannjjm 1705 6 to to TO cord-023095-4dannjjm 1705 7 achieve achieve VB cord-023095-4dannjjm 1705 8 therapeutic therapeutic JJ cord-023095-4dannjjm 1705 9 concentrations concentration NNS cord-023095-4dannjjm 1705 10 in in IN cord-023095-4dannjjm 1705 11 cerebrospinal cerebrospinal JJ cord-023095-4dannjjm 1705 12 fluid fluid NN cord-023095-4dannjjm 1705 13 following follow VBG cord-023095-4dannjjm 1705 14 routine routine JJ cord-023095-4dannjjm 1705 15 administration administration NN cord-023095-4dannjjm 1705 16 , , , cord-023095-4dannjjm 1705 17 this this DT cord-023095-4dannjjm 1705 18 would would MD cord-023095-4dannjjm 1705 19 be be VB cord-023095-4dannjjm 1705 20 an an DT cord-023095-4dannjjm 1705 21 exciting exciting JJ cord-023095-4dannjjm 1705 22 advance advance NN cord-023095-4dannjjm 1705 23 for for IN cord-023095-4dannjjm 1705 24 the the DT cord-023095-4dannjjm 1705 25 treatment treatment NN cord-023095-4dannjjm 1705 26 of of IN cord-023095-4dannjjm 1705 27 meningitis meningitis NN cord-023095-4dannjjm 1705 28 in in IN cord-023095-4dannjjm 1705 29 the the DT cord-023095-4dannjjm 1705 30 horse horse NN cord-023095-4dannjjm 1705 31 . . . cord-023095-4dannjjm 1706 1 5 5 CD cord-023095-4dannjjm 1706 2 mature mature JJ cord-023095-4dannjjm 1706 3 , , , cord-023095-4dannjjm 1706 4 healthy healthy JJ cord-023095-4dannjjm 1706 5 horses horse NNS cord-023095-4dannjjm 1706 6 were be VBD cord-023095-4dannjjm 1706 7 used use VBN cord-023095-4dannjjm 1706 8 on on IN cord-023095-4dannjjm 1706 9 2 2 CD cord-023095-4dannjjm 1706 10 separate separate JJ cord-023095-4dannjjm 1706 11 occasions occasion NNS cord-023095-4dannjjm 1706 12 , , , cord-023095-4dannjjm 1706 13 seven seven CD cord-023095-4dannjjm 1706 14 days day NNS cord-023095-4dannjjm 1706 15 apart apart RB cord-023095-4dannjjm 1706 16 , , , cord-023095-4dannjjm 1706 17 in in IN cord-023095-4dannjjm 1706 18 a a DT cord-023095-4dannjjm 1706 19 crossover crossover NN cord-023095-4dannjjm 1706 20 design design NN cord-023095-4dannjjm 1706 21 . . . cord-023095-4dannjjm 1707 1 Each each DT cord-023095-4dannjjm 1707 2 horse horse NN cord-023095-4dannjjm 1707 3 was be VBD cord-023095-4dannjjm 1707 4 administered administer VBN cord-023095-4dannjjm 1707 5 either either CC cord-023095-4dannjjm 1707 6 cefquinome cefquinome NNP cord-023095-4dannjjm 1707 7 ( ( -LRB- cord-023095-4dannjjm 1707 8 1 1 CD cord-023095-4dannjjm 1707 9 mg mg NNP cord-023095-4dannjjm 1707 10 / / SYM cord-023095-4dannjjm 1707 11 kg kg NNP cord-023095-4dannjjm 1707 12 ) ) -RRB- cord-023095-4dannjjm 1707 13 or or CC cord-023095-4dannjjm 1707 14 saline saline NN cord-023095-4dannjjm 1707 15 ( ( -LRB- cord-023095-4dannjjm 1707 16 equivalent equivalent JJ cord-023095-4dannjjm 1707 17 volume volume NN cord-023095-4dannjjm 1707 18 ) ) -RRB- cord-023095-4dannjjm 1707 19 . . . cord-023095-4dannjjm 1708 1 Cerebrospinal cerebrospinal NN cord-023095-4dannjjm 1708 2 fluid fluid NN cord-023095-4dannjjm 1708 3 was be VBD cord-023095-4dannjjm 1708 4 collected collect VBN cord-023095-4dannjjm 1708 5 via via IN cord-023095-4dannjjm 1708 6 atlanto atlanto XX cord-023095-4dannjjm 1708 7 - - HYPH cord-023095-4dannjjm 1708 8 occipital occipital JJ cord-023095-4dannjjm 1708 9 puncture puncture NN cord-023095-4dannjjm 1708 10 under under IN cord-023095-4dannjjm 1708 11 general general JJ cord-023095-4dannjjm 1708 12 anaesthesia anaesthesia NN cord-023095-4dannjjm 1708 13 1 1 CD cord-023095-4dannjjm 1708 14 and and CC cord-023095-4dannjjm 1708 15 4 4 CD cord-023095-4dannjjm 1708 16 hours hour NNS cord-023095-4dannjjm 1708 17 after after IN cord-023095-4dannjjm 1708 18 administration administration NN cord-023095-4dannjjm 1708 19 of of IN cord-023095-4dannjjm 1708 20 cefquinome cefquinome NNP cord-023095-4dannjjm 1708 21 or or CC cord-023095-4dannjjm 1708 22 saline saline NN cord-023095-4dannjjm 1708 23 placebo placebo NN cord-023095-4dannjjm 1708 24 . . . cord-023095-4dannjjm 1709 1 Blood blood NN cord-023095-4dannjjm 1709 2 samples sample NNS cord-023095-4dannjjm 1709 3 were be VBD cord-023095-4dannjjm 1709 4 collected collect VBN cord-023095-4dannjjm 1709 5 prior prior RB cord-023095-4dannjjm 1709 6 to to IN cord-023095-4dannjjm 1709 7 , , , cord-023095-4dannjjm 1709 8 and and CC cord-023095-4dannjjm 1709 9 1 1 CD cord-023095-4dannjjm 1709 10 and and CC cord-023095-4dannjjm 1709 11 4 4 CD cord-023095-4dannjjm 1709 12 hours hour NNS cord-023095-4dannjjm 1709 13 after after IN cord-023095-4dannjjm 1709 14 administration administration NN cord-023095-4dannjjm 1709 15 of of IN cord-023095-4dannjjm 1709 16 cefquinome cefquinome NNP cord-023095-4dannjjm 1709 17 or or CC cord-023095-4dannjjm 1709 18 placebo placebo NN cord-023095-4dannjjm 1709 19 . . . cord-023095-4dannjjm 1710 1 All all DT cord-023095-4dannjjm 1710 2 samples sample NNS cord-023095-4dannjjm 1710 3 were be VBD cord-023095-4dannjjm 1710 4 analysed analyse VBN cord-023095-4dannjjm 1710 5 for for IN cord-023095-4dannjjm 1710 6 the the DT cord-023095-4dannjjm 1710 7 presence presence NN cord-023095-4dannjjm 1710 8 of of IN cord-023095-4dannjjm 1710 9 cefquinome cefquinome NNP cord-023095-4dannjjm 1710 10 by by IN cord-023095-4dannjjm 1710 11 a a DT cord-023095-4dannjjm 1710 12 laboratory laboratory NN cord-023095-4dannjjm 1710 13 masked mask VBN cord-023095-4dannjjm 1710 14 to to IN cord-023095-4dannjjm 1710 15 treatments treatment NNS cord-023095-4dannjjm 1710 16 administered administer VBN cord-023095-4dannjjm 1710 17 . . . cord-023095-4dannjjm 1711 1 Cefquinome Cefquinome NNP cord-023095-4dannjjm 1711 2 was be VBD cord-023095-4dannjjm 1711 3 detectable detectable JJ cord-023095-4dannjjm 1711 4 in in IN cord-023095-4dannjjm 1711 5 the the DT cord-023095-4dannjjm 1711 6 cerebrospinal cerebrospinal JJ cord-023095-4dannjjm 1711 7 fluid fluid NN cord-023095-4dannjjm 1711 8 in in IN cord-023095-4dannjjm 1711 9 all all DT cord-023095-4dannjjm 1711 10 horses horse NNS cord-023095-4dannjjm 1711 11 4 4 CD cord-023095-4dannjjm 1711 12 hours hour NNS cord-023095-4dannjjm 1711 13 after after IN cord-023095-4dannjjm 1711 14 intravenous intravenous JJ cord-023095-4dannjjm 1711 15 administration administration NN cord-023095-4dannjjm 1711 16 , , , cord-023095-4dannjjm 1711 17 and and CC cord-023095-4dannjjm 1711 18 in in IN cord-023095-4dannjjm 1711 19 2 2 CD cord-023095-4dannjjm 1711 20 horses horse NNS cord-023095-4dannjjm 1711 21 1 1 CD cord-023095-4dannjjm 1711 22 hour hour NN cord-023095-4dannjjm 1711 23 after after IN cord-023095-4dannjjm 1711 24 administration administration NN cord-023095-4dannjjm 1711 25 . . . cord-023095-4dannjjm 1712 1 Cefquinome Cefquinome NNP cord-023095-4dannjjm 1712 2 penetrates penetrate VBZ cord-023095-4dannjjm 1712 3 the the DT cord-023095-4dannjjm 1712 4 blood blood NN cord-023095-4dannjjm 1712 5 - - HYPH cord-023095-4dannjjm 1712 6 brain brain NN cord-023095-4dannjjm 1712 7 barrier barrier NN cord-023095-4dannjjm 1712 8 and and CC cord-023095-4dannjjm 1712 9 it -PRON- PRP cord-023095-4dannjjm 1712 10 is be VBZ cord-023095-4dannjjm 1712 11 therefore therefore RB cord-023095-4dannjjm 1712 12 a a DT cord-023095-4dannjjm 1712 13 potential potential JJ cord-023095-4dannjjm 1712 14 treatment treatment NN cord-023095-4dannjjm 1712 15 for for IN cord-023095-4dannjjm 1712 16 equine equine JJ cord-023095-4dannjjm 1712 17 meningitis meningitis NN cord-023095-4dannjjm 1712 18 . . . cord-023095-4dannjjm 1713 1 Further further JJ cord-023095-4dannjjm 1713 2 investigation investigation NN cord-023095-4dannjjm 1713 3 of of IN cord-023095-4dannjjm 1713 4 the the DT cord-023095-4dannjjm 1713 5 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 1713 6 and and CC cord-023095-4dannjjm 1713 7 pharmacodynamics pharmacodynamic NNS cord-023095-4dannjjm 1713 8 of of IN cord-023095-4dannjjm 1713 9 cefquinome cefquinome NNP cord-023095-4dannjjm 1713 10 in in IN cord-023095-4dannjjm 1713 11 the the DT cord-023095-4dannjjm 1713 12 cerebrospinal cerebrospinal JJ cord-023095-4dannjjm 1713 13 fluid fluid NN cord-023095-4dannjjm 1713 14 is be VBZ cord-023095-4dannjjm 1713 15 warranted warrant VBN cord-023095-4dannjjm 1713 16 to to TO cord-023095-4dannjjm 1713 17 establish establish VB cord-023095-4dannjjm 1713 18 the the DT cord-023095-4dannjjm 1713 19 optimum optimum JJ cord-023095-4dannjjm 1713 20 intravenous intravenous JJ cord-023095-4dannjjm 1713 21 dose dose NN cord-023095-4dannjjm 1713 22 . . . cord-023095-4dannjjm 1714 1 The the DT cord-023095-4dannjjm 1714 2 purpose purpose NN cord-023095-4dannjjm 1714 3 of of IN cord-023095-4dannjjm 1714 4 this this DT cord-023095-4dannjjm 1714 5 study study NN cord-023095-4dannjjm 1714 6 was be VBD cord-023095-4dannjjm 1714 7 to to TO cord-023095-4dannjjm 1714 8 determine determine VB cord-023095-4dannjjm 1714 9 if if IN cord-023095-4dannjjm 1714 10 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 1714 11 alters alter VBZ cord-023095-4dannjjm 1714 12 the the DT cord-023095-4dannjjm 1714 13 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 1714 14 of of IN cord-023095-4dannjjm 1714 15 firocoxib firocoxib NNP cord-023095-4dannjjm 1714 16 in in IN cord-023095-4dannjjm 1714 17 the the DT cord-023095-4dannjjm 1714 18 horse horse NN cord-023095-4dannjjm 1714 19 . . . cord-023095-4dannjjm 1715 1 Firocoxib Firocoxib NNP cord-023095-4dannjjm 1715 2 is be VBZ cord-023095-4dannjjm 1715 3 a a DT cord-023095-4dannjjm 1715 4 coxibclass coxibclass NNP cord-023095-4dannjjm 1715 5 nonsteroidal nonsteroidal JJ cord-023095-4dannjjm 1715 6 anti anti JJ cord-023095-4dannjjm 1715 7 - - JJ cord-023095-4dannjjm 1715 8 inflammatory inflammatory JJ cord-023095-4dannjjm 1715 9 drug drug NN cord-023095-4dannjjm 1715 10 ( ( -LRB- cord-023095-4dannjjm 1715 11 NSAID NSAID NNP cord-023095-4dannjjm 1715 12 ) ) -RRB- cord-023095-4dannjjm 1715 13 approved approve VBD cord-023095-4dannjjm 1715 14 for for IN cord-023095-4dannjjm 1715 15 use use NN cord-023095-4dannjjm 1715 16 in in IN cord-023095-4dannjjm 1715 17 horses horse NNS cord-023095-4dannjjm 1715 18 to to TO cord-023095-4dannjjm 1715 19 control control VB cord-023095-4dannjjm 1715 20 pain pain NN cord-023095-4dannjjm 1715 21 and and CC cord-023095-4dannjjm 1715 22 inflammation inflammation NN cord-023095-4dannjjm 1715 23 associated associate VBN cord-023095-4dannjjm 1715 24 with with IN cord-023095-4dannjjm 1715 25 osteoarthritis osteoarthritis NN cord-023095-4dannjjm 1715 26 . . . cord-023095-4dannjjm 1716 1 Dosages dosage NNS cord-023095-4dannjjm 1716 2 of of IN cord-023095-4dannjjm 1716 3 firocoxib firocoxib NNS cord-023095-4dannjjm 1716 4 are be VBP cord-023095-4dannjjm 1716 5 species specie NNS cord-023095-4dannjjm 1716 6 dependent dependent JJ cord-023095-4dannjjm 1716 7 , , , cord-023095-4dannjjm 1716 8 with with IN cord-023095-4dannjjm 1716 9 the the DT cord-023095-4dannjjm 1716 10 recommended recommend VBN cord-023095-4dannjjm 1716 11 dose dose NN cord-023095-4dannjjm 1716 12 for for IN cord-023095-4dannjjm 1716 13 horses horse NNS cord-023095-4dannjjm 1716 14 being be VBG cord-023095-4dannjjm 1716 15 0.1 0.1 CD cord-023095-4dannjjm 1716 16 mg mg NNP cord-023095-4dannjjm 1716 17 / / SYM cord-023095-4dannjjm 1716 18 kg kg NNP cord-023095-4dannjjm 1716 19 as as IN cord-023095-4dannjjm 1716 20 an an DT cord-023095-4dannjjm 1716 21 oral oral JJ cord-023095-4dannjjm 1716 22 paste paste NN cord-023095-4dannjjm 1716 23 every every DT cord-023095-4dannjjm 1716 24 24 24 CD cord-023095-4dannjjm 1716 25 h. h. NN cord-023095-4dannjjm 1717 1 The the DT cord-023095-4dannjjm 1717 2 main main JJ cord-023095-4dannjjm 1717 3 elimination elimination NN cord-023095-4dannjjm 1717 4 pathway pathway NN cord-023095-4dannjjm 1717 5 of of IN cord-023095-4dannjjm 1717 6 firocoxib firocoxib NNP cord-023095-4dannjjm 1717 7 is be VBZ cord-023095-4dannjjm 1717 8 hepatic hepatic JJ cord-023095-4dannjjm 1717 9 ; ; : cord-023095-4dannjjm 1717 10 however however RB cord-023095-4dannjjm 1717 11 the the DT cord-023095-4dannjjm 1717 12 effects effect NNS cord-023095-4dannjjm 1717 13 of of IN cord-023095-4dannjjm 1717 14 concurrent concurrent JJ cord-023095-4dannjjm 1717 15 administration administration NN cord-023095-4dannjjm 1717 16 of of IN cord-023095-4dannjjm 1717 17 drugs drug NNS cord-023095-4dannjjm 1717 18 that that WDT cord-023095-4dannjjm 1717 19 may may MD cord-023095-4dannjjm 1717 20 inhibit inhibit VB cord-023095-4dannjjm 1717 21 its -PRON- PRP$ cord-023095-4dannjjm 1717 22 metabolism metabolism NN cord-023095-4dannjjm 1717 23 have have VBP cord-023095-4dannjjm 1717 24 not not RB cord-023095-4dannjjm 1717 25 been be VBN cord-023095-4dannjjm 1717 26 evaluated evaluate VBN cord-023095-4dannjjm 1717 27 . . . cord-023095-4dannjjm 1718 1 Enrofloxacin Enrofloxacin NNP cord-023095-4dannjjm 1718 2 is be VBZ cord-023095-4dannjjm 1718 3 a a DT cord-023095-4dannjjm 1718 4 synthetic synthetic JJ cord-023095-4dannjjm 1718 5 antibacterial antibacterial JJ cord-023095-4dannjjm 1718 6 agent agent NN cord-023095-4dannjjm 1718 7 from from IN cord-023095-4dannjjm 1718 8 the the DT cord-023095-4dannjjm 1718 9 flouroquinolone flouroquinolone NNP cord-023095-4dannjjm 1718 10 group group NN cord-023095-4dannjjm 1718 11 developed develop VBN cord-023095-4dannjjm 1718 12 for for IN cord-023095-4dannjjm 1718 13 veterinary veterinary JJ cord-023095-4dannjjm 1718 14 use use NN cord-023095-4dannjjm 1718 15 . . . cord-023095-4dannjjm 1719 1 It -PRON- PRP cord-023095-4dannjjm 1719 2 is be VBZ cord-023095-4dannjjm 1719 3 primarily primarily RB cord-023095-4dannjjm 1719 4 used use VBN cord-023095-4dannjjm 1719 5 for for IN cord-023095-4dannjjm 1719 6 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 1719 7 , , , cord-023095-4dannjjm 1719 8 urogenital urogenital JJ cord-023095-4dannjjm 1719 9 , , , cord-023095-4dannjjm 1719 10 skin skin NN cord-023095-4dannjjm 1719 11 and and CC cord-023095-4dannjjm 1719 12 respiratory respiratory JJ cord-023095-4dannjjm 1719 13 tract tract NN cord-023095-4dannjjm 1719 14 infections infection NNS cord-023095-4dannjjm 1719 15 in in IN cord-023095-4dannjjm 1719 16 various various JJ cord-023095-4dannjjm 1719 17 animals animal NNS cord-023095-4dannjjm 1719 18 . . . cord-023095-4dannjjm 1720 1 A a DT cord-023095-4dannjjm 1720 2 well well RB cord-023095-4dannjjm 1720 3 acknowledged acknowledge VBN cord-023095-4dannjjm 1720 4 problem problem NN cord-023095-4dannjjm 1720 5 associated associate VBN cord-023095-4dannjjm 1720 6 with with IN cord-023095-4dannjjm 1720 7 flouroquinolone flouroquinolone JJ cord-023095-4dannjjm 1720 8 usage usage NN cord-023095-4dannjjm 1720 9 is be VBZ cord-023095-4dannjjm 1720 10 their -PRON- PRP$ cord-023095-4dannjjm 1720 11 effect effect NN cord-023095-4dannjjm 1720 12 on on IN cord-023095-4dannjjm 1720 13 the the DT cord-023095-4dannjjm 1720 14 metabolism metabolism NN cord-023095-4dannjjm 1720 15 of of IN cord-023095-4dannjjm 1720 16 other other JJ cord-023095-4dannjjm 1720 17 drugs drug NNS cord-023095-4dannjjm 1720 18 . . . cord-023095-4dannjjm 1721 1 Co co NN cord-023095-4dannjjm 1721 2 - - NN cord-023095-4dannjjm 1721 3 administration administration NN cord-023095-4dannjjm 1721 4 of of IN cord-023095-4dannjjm 1721 5 multiple multiple JJ cord-023095-4dannjjm 1721 6 drugs drug NNS cord-023095-4dannjjm 1721 7 can can MD cord-023095-4dannjjm 1721 8 result result VB cord-023095-4dannjjm 1721 9 in in IN cord-023095-4dannjjm 1721 10 unpredictable unpredictable JJ cord-023095-4dannjjm 1721 11 therapeutic therapeutic JJ cord-023095-4dannjjm 1721 12 outcomes outcome NNS cord-023095-4dannjjm 1721 13 . . . cord-023095-4dannjjm 1722 1 Often often RB cord-023095-4dannjjm 1722 2 it -PRON- PRP cord-023095-4dannjjm 1722 3 is be VBZ cord-023095-4dannjjm 1722 4 either either CC cord-023095-4dannjjm 1722 5 diminished diminish VBN cord-023095-4dannjjm 1722 6 therapeutic therapeutic JJ cord-023095-4dannjjm 1722 7 efficacy efficacy NN cord-023095-4dannjjm 1722 8 or or CC cord-023095-4dannjjm 1722 9 increased increase VBN cord-023095-4dannjjm 1722 10 toxicity toxicity NN cord-023095-4dannjjm 1722 11 of of IN cord-023095-4dannjjm 1722 12 one one CD cord-023095-4dannjjm 1722 13 or or CC cord-023095-4dannjjm 1722 14 more more JJR cord-023095-4dannjjm 1722 15 of of IN cord-023095-4dannjjm 1722 16 the the DT cord-023095-4dannjjm 1722 17 administered administer VBN cord-023095-4dannjjm 1722 18 drugs drug NNS cord-023095-4dannjjm 1722 19 . . . cord-023095-4dannjjm 1723 1 Various various JJ cord-023095-4dannjjm 1723 2 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 1723 3 interactions interaction NNS cord-023095-4dannjjm 1723 4 between between IN cord-023095-4dannjjm 1723 5 antimicrobials antimicrobial NNS cord-023095-4dannjjm 1723 6 and and CC cord-023095-4dannjjm 1723 7 NSAIDs nsaid NNS cord-023095-4dannjjm 1723 8 have have VBP cord-023095-4dannjjm 1723 9 been be VBN cord-023095-4dannjjm 1723 10 described describe VBN cord-023095-4dannjjm 1723 11 . . . cord-023095-4dannjjm 1724 1 Six six CD cord-023095-4dannjjm 1724 2 healthy healthy JJ cord-023095-4dannjjm 1724 3 , , , cord-023095-4dannjjm 1724 4 adult adult NN cord-023095-4dannjjm 1724 5 mares mare NNS cord-023095-4dannjjm 1724 6 were be VBD cord-023095-4dannjjm 1724 7 administered administer VBN cord-023095-4dannjjm 1724 8 0.1 0.1 CD cord-023095-4dannjjm 1724 9 mg mg NNP cord-023095-4dannjjm 1724 10 / / SYM cord-023095-4dannjjm 1724 11 kg kg NNS cord-023095-4dannjjm 1724 12 of of IN cord-023095-4dannjjm 1724 13 firocoxib firocoxib NN cord-023095-4dannjjm 1724 14 orally orally RB cord-023095-4dannjjm 1724 15 . . . cord-023095-4dannjjm 1725 1 Samples sample NNS cord-023095-4dannjjm 1725 2 were be VBD cord-023095-4dannjjm 1725 3 collected collect VBN cord-023095-4dannjjm 1725 4 by by IN cord-023095-4dannjjm 1725 5 direct direct JJ cord-023095-4dannjjm 1725 6 venipuncture venipuncture NN cord-023095-4dannjjm 1725 7 of of IN cord-023095-4dannjjm 1725 8 the the DT cord-023095-4dannjjm 1725 9 jugular jugular NN cord-023095-4dannjjm 1725 10 vein vein NN cord-023095-4dannjjm 1725 11 at at IN cord-023095-4dannjjm 1725 12 0 0 NFP cord-023095-4dannjjm 1725 13 ( ( -LRB- cord-023095-4dannjjm 1725 14 control control NN cord-023095-4dannjjm 1725 15 ) ) -RRB- cord-023095-4dannjjm 1725 16 , , , cord-023095-4dannjjm 1725 17 15 15 CD cord-023095-4dannjjm 1725 18 , , , cord-023095-4dannjjm 1725 19 30 30 CD cord-023095-4dannjjm 1725 20 , , , cord-023095-4dannjjm 1725 21 and and CC cord-023095-4dannjjm 1725 22 60 60 CD cord-023095-4dannjjm 1725 23 min min NN cord-023095-4dannjjm 1725 24 , , , cord-023095-4dannjjm 1725 25 2 2 CD cord-023095-4dannjjm 1725 26 , , , cord-023095-4dannjjm 1725 27 4 4 CD cord-023095-4dannjjm 1725 28 , , , cord-023095-4dannjjm 1725 29 8 8 CD cord-023095-4dannjjm 1725 30 , , , cord-023095-4dannjjm 1725 31 12 12 CD cord-023095-4dannjjm 1725 32 , , , cord-023095-4dannjjm 1725 33 16 16 CD cord-023095-4dannjjm 1725 34 , , , cord-023095-4dannjjm 1725 35 24 24 CD cord-023095-4dannjjm 1725 36 , , , cord-023095-4dannjjm 1725 37 48 48 CD cord-023095-4dannjjm 1725 38 , , , cord-023095-4dannjjm 1725 39 72 72 CD cord-023095-4dannjjm 1725 40 , , , cord-023095-4dannjjm 1725 41 and and CC cord-023095-4dannjjm 1725 42 96 96 CD cord-023095-4dannjjm 1725 43 h h NN cord-023095-4dannjjm 1725 44 after after IN cord-023095-4dannjjm 1725 45 administration administration NN cord-023095-4dannjjm 1725 46 . . . cord-023095-4dannjjm 1726 1 After after IN cord-023095-4dannjjm 1726 2 a a DT cord-023095-4dannjjm 1726 3 20 20 CD cord-023095-4dannjjm 1726 4 day day NN cord-023095-4dannjjm 1726 5 washout washout NN cord-023095-4dannjjm 1726 6 period period NN cord-023095-4dannjjm 1726 7 the the DT cord-023095-4dannjjm 1726 8 six six CD cord-023095-4dannjjm 1726 9 horses horse NNS cord-023095-4dannjjm 1726 10 were be VBD cord-023095-4dannjjm 1726 11 pretreated pretreate VBN cord-023095-4dannjjm 1726 12 3 3 CD cord-023095-4dannjjm 1726 13 days day NNS cord-023095-4dannjjm 1726 14 with with IN cord-023095-4dannjjm 1726 15 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 1727 1 5 5 CD cord-023095-4dannjjm 1727 2 mg mg NNP cord-023095-4dannjjm 1727 3 / / SYM cord-023095-4dannjjm 1727 4 kg kg XX cord-023095-4dannjjm 1727 5 intravenously intravenously RB cord-023095-4dannjjm 1727 6 every every DT cord-023095-4dannjjm 1727 7 24 24 CD cord-023095-4dannjjm 1727 8 h h NN cord-023095-4dannjjm 1727 9 then then RB cord-023095-4dannjjm 1727 10 on on IN cord-023095-4dannjjm 1727 11 the the DT cord-023095-4dannjjm 1727 12 fourth fourth JJ cord-023095-4dannjjm 1727 13 day day NN cord-023095-4dannjjm 1727 14 given give VBN cord-023095-4dannjjm 1727 15 0.1 0.1 CD cord-023095-4dannjjm 1727 16 mg mg NNP cord-023095-4dannjjm 1727 17 / / SYM cord-023095-4dannjjm 1727 18 kg kg NNS cord-023095-4dannjjm 1727 19 of of IN cord-023095-4dannjjm 1727 20 firocoxib firocoxib NN cord-023095-4dannjjm 1727 21 orally orally RB cord-023095-4dannjjm 1727 22 . . . cord-023095-4dannjjm 1728 1 Samples sample NNS cord-023095-4dannjjm 1728 2 were be VBD cord-023095-4dannjjm 1728 3 collected collect VBN cord-023095-4dannjjm 1728 4 at at IN cord-023095-4dannjjm 1728 5 0 0 CD cord-023095-4dannjjm 1728 6 ( ( -LRB- cord-023095-4dannjjm 1728 7 control control NN cord-023095-4dannjjm 1728 8 ) ) -RRB- cord-023095-4dannjjm 1728 9 , , , cord-023095-4dannjjm 1728 10 15 15 CD cord-023095-4dannjjm 1728 11 , , , cord-023095-4dannjjm 1728 12 30 30 CD cord-023095-4dannjjm 1728 13 , , , cord-023095-4dannjjm 1728 14 and and CC cord-023095-4dannjjm 1728 15 60 60 CD cord-023095-4dannjjm 1728 16 min min NN cord-023095-4dannjjm 1728 17 , , , cord-023095-4dannjjm 1728 18 2 2 CD cord-023095-4dannjjm 1728 19 , , , cord-023095-4dannjjm 1728 20 4 4 CD cord-023095-4dannjjm 1728 21 , , , cord-023095-4dannjjm 1728 22 8 8 CD cord-023095-4dannjjm 1728 23 , , , cord-023095-4dannjjm 1728 24 12 12 CD cord-023095-4dannjjm 1728 25 , , , cord-023095-4dannjjm 1728 26 16 16 CD cord-023095-4dannjjm 1728 27 , , , cord-023095-4dannjjm 1728 28 24 24 CD cord-023095-4dannjjm 1728 29 , , , cord-023095-4dannjjm 1728 30 48 48 CD cord-023095-4dannjjm 1728 31 , , , cord-023095-4dannjjm 1728 32 72 72 CD cord-023095-4dannjjm 1728 33 , , , cord-023095-4dannjjm 1728 34 and and CC cord-023095-4dannjjm 1728 35 96 96 CD cord-023095-4dannjjm 1728 36 h h NN cord-023095-4dannjjm 1728 37 after after IN cord-023095-4dannjjm 1728 38 administration administration NN cord-023095-4dannjjm 1728 39 . . . cord-023095-4dannjjm 1729 1 All all DT cord-023095-4dannjjm 1729 2 samples sample NNS cord-023095-4dannjjm 1729 3 were be VBD cord-023095-4dannjjm 1729 4 stored store VBN cord-023095-4dannjjm 1729 5 at at IN cord-023095-4dannjjm 1729 6 À801C À801C NNPS cord-023095-4dannjjm 1729 7 until until IN cord-023095-4dannjjm 1729 8 analysis analysis NN cord-023095-4dannjjm 1729 9 using use VBG cord-023095-4dannjjm 1729 10 a a DT cord-023095-4dannjjm 1729 11 validated validate VBN cord-023095-4dannjjm 1729 12 HPLC HPLC NNP cord-023095-4dannjjm 1729 13 method method NN cord-023095-4dannjjm 1729 14 . . . cord-023095-4dannjjm 1730 1 The the DT cord-023095-4dannjjm 1730 2 t1/2 t1/2 NN cord-023095-4dannjjm 1730 3 , , , cord-023095-4dannjjm 1730 4 C C NNP cord-023095-4dannjjm 1730 5 max max NN cord-023095-4dannjjm 1730 6 , , , cord-023095-4dannjjm 1730 7 T T NNP cord-023095-4dannjjm 1730 8 max max NN cord-023095-4dannjjm 1730 9 , , , cord-023095-4dannjjm 1730 10 AUC AUC NNP cord-023095-4dannjjm 1730 11 0 0 CD cord-023095-4dannjjm 1730 12 - - HYPH cord-023095-4dannjjm 1730 13 24 24 CD cord-023095-4dannjjm 1730 14 and and CC cord-023095-4dannjjm 1730 15 AUC AUC NNP cord-023095-4dannjjm 1730 16 0-f 0-f CD cord-023095-4dannjjm 1730 17 after after IN cord-023095-4dannjjm 1730 18 firocoxib firocoxib NNP cord-023095-4dannjjm 1730 19 administration administration NNP cord-023095-4dannjjm 1730 20 were be VBD cord-023095-4dannjjm 1730 21 30 30 CD cord-023095-4dannjjm 1730 22 . . . cord-023095-4dannjjm 1731 1 66 66 CD cord-023095-4dannjjm 1732 1 Angiotensin angiotensin NN cord-023095-4dannjjm 1732 2 converting convert VBG cord-023095-4dannjjm 1732 3 enzyme enzyme NN cord-023095-4dannjjm 1732 4 ( ( -LRB- cord-023095-4dannjjm 1732 5 ACE ACE NNP cord-023095-4dannjjm 1732 6 ) ) -RRB- cord-023095-4dannjjm 1732 7 inhibitors inhibitor NNS cord-023095-4dannjjm 1732 8 improve improve VBP cord-023095-4dannjjm 1732 9 survival survival NN cord-023095-4dannjjm 1732 10 and and CC cord-023095-4dannjjm 1732 11 quality quality NN cord-023095-4dannjjm 1732 12 of of IN cord-023095-4dannjjm 1732 13 life life NN cord-023095-4dannjjm 1732 14 in in IN cord-023095-4dannjjm 1732 15 humans human NNS cord-023095-4dannjjm 1732 16 and and CC cord-023095-4dannjjm 1732 17 small small JJ cord-023095-4dannjjm 1732 18 animals animal NNS cord-023095-4dannjjm 1732 19 with with IN cord-023095-4dannjjm 1732 20 cardiovascular cardiovascular JJ cord-023095-4dannjjm 1732 21 and and CC cord-023095-4dannjjm 1732 22 renal renal JJ cord-023095-4dannjjm 1732 23 disease disease NN cord-023095-4dannjjm 1732 24 . . . cord-023095-4dannjjm 1733 1 There there EX cord-023095-4dannjjm 1733 2 is be VBZ cord-023095-4dannjjm 1733 3 limited limited JJ cord-023095-4dannjjm 1733 4 information information NN cord-023095-4dannjjm 1733 5 regarding regard VBG cord-023095-4dannjjm 1733 6 their -PRON- PRP$ cord-023095-4dannjjm 1733 7 effects effect NNS cord-023095-4dannjjm 1733 8 in in IN cord-023095-4dannjjm 1733 9 horses horse NNS cord-023095-4dannjjm 1733 10 . . . cord-023095-4dannjjm 1734 1 The the DT cord-023095-4dannjjm 1734 2 purpose purpose NN cord-023095-4dannjjm 1734 3 of of IN cord-023095-4dannjjm 1734 4 this this DT cord-023095-4dannjjm 1734 5 study study NN cord-023095-4dannjjm 1734 6 was be VBD cord-023095-4dannjjm 1734 7 to to TO cord-023095-4dannjjm 1734 8 determine determine VB cord-023095-4dannjjm 1734 9 the the DT cord-023095-4dannjjm 1734 10 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 1734 11 of of IN cord-023095-4dannjjm 1734 12 quinapril quinapril NNP cord-023095-4dannjjm 1734 13 and and CC cord-023095-4dannjjm 1734 14 its -PRON- PRP$ cord-023095-4dannjjm 1734 15 effects effect NNS cord-023095-4dannjjm 1734 16 on on IN cord-023095-4dannjjm 1734 17 ACE ace NN cord-023095-4dannjjm 1734 18 inhibition inhibition NN cord-023095-4dannjjm 1734 19 in in IN cord-023095-4dannjjm 1734 20 horses horse NNS cord-023095-4dannjjm 1734 21 . . . cord-023095-4dannjjm 1735 1 Six six CD cord-023095-4dannjjm 1735 2 healthy healthy JJ cord-023095-4dannjjm 1735 3 horses horse NNS cord-023095-4dannjjm 1735 4 were be VBD cord-023095-4dannjjm 1735 5 administered administer VBN cord-023095-4dannjjm 1735 6 quinapril quinapril NNP cord-023095-4dannjjm 1735 7 at at IN cord-023095-4dannjjm 1735 8 120 120 CD cord-023095-4dannjjm 1735 9 mg mg NNP cord-023095-4dannjjm 1735 10 IV IV NNP cord-023095-4dannjjm 1735 11 , , , cord-023095-4dannjjm 1735 12 120 120 CD cord-023095-4dannjjm 1735 13 mg mg NNP cord-023095-4dannjjm 1735 14 PO PO NNP cord-023095-4dannjjm 1735 15 or or CC cord-023095-4dannjjm 1735 16 240 240 CD cord-023095-4dannjjm 1735 17 mg mg NNP cord-023095-4dannjjm 1735 18 PO PO NNP cord-023095-4dannjjm 1735 19 in in IN cord-023095-4dannjjm 1735 20 a a DT cord-023095-4dannjjm 1735 21 3-way 3-way JJ cord-023095-4dannjjm 1735 22 crossover crossover NN cord-023095-4dannjjm 1735 23 design design NN cord-023095-4dannjjm 1735 24 . . . cord-023095-4dannjjm 1736 1 Blood blood NN cord-023095-4dannjjm 1736 2 was be VBD cord-023095-4dannjjm 1736 3 collected collect VBN cord-023095-4dannjjm 1736 4 at at IN cord-023095-4dannjjm 1736 5 predetermined predetermined JJ cord-023095-4dannjjm 1736 6 times time NNS cord-023095-4dannjjm 1736 7 for for IN cord-023095-4dannjjm 1736 8 measurement measurement NN cord-023095-4dannjjm 1736 9 of of IN cord-023095-4dannjjm 1736 10 quinapril quinapril NNP cord-023095-4dannjjm 1736 11 and and CC cord-023095-4dannjjm 1736 12 quinaprilat quinaprilat NNP cord-023095-4dannjjm 1736 13 concentrations concentration NNS cord-023095-4dannjjm 1736 14 using use VBG cord-023095-4dannjjm 1736 15 high high JJ cord-023095-4dannjjm 1736 16 pressure pressure NN cord-023095-4dannjjm 1736 17 liquid liquid NN cord-023095-4dannjjm 1736 18 chromatography chromatography NN cord-023095-4dannjjm 1736 19 , , , cord-023095-4dannjjm 1736 20 as as RB cord-023095-4dannjjm 1736 21 well well RB cord-023095-4dannjjm 1736 22 as as IN cord-023095-4dannjjm 1736 23 ACE ace NN cord-023095-4dannjjm 1736 24 concentrations concentration NNS cord-023095-4dannjjm 1736 25 using use VBG cord-023095-4dannjjm 1736 26 a a DT cord-023095-4dannjjm 1736 27 radioenzymatic radioenzymatic JJ cord-023095-4dannjjm 1736 28 assay assay NN cord-023095-4dannjjm 1736 29 . . . cord-023095-4dannjjm 1737 1 Normally normally RB cord-023095-4dannjjm 1737 2 distributed distribute VBN cord-023095-4dannjjm 1737 3 data datum NNS cord-023095-4dannjjm 1737 4 were be VBD cord-023095-4dannjjm 1737 5 analyzed analyze VBN cord-023095-4dannjjm 1737 6 with with IN cord-023095-4dannjjm 1737 7 one one CD cord-023095-4dannjjm 1737 8 way way NN cord-023095-4dannjjm 1737 9 repeated repeat VBN cord-023095-4dannjjm 1737 10 measures measure NNS cord-023095-4dannjjm 1737 11 analysis analysis NN cord-023095-4dannjjm 1737 12 of of IN cord-023095-4dannjjm 1737 13 variance variance NN cord-023095-4dannjjm 1737 14 ( ( -LRB- cord-023095-4dannjjm 1737 15 RM rm NN cord-023095-4dannjjm 1737 16 - - HYPH cord-023095-4dannjjm 1737 17 ANOVA ANOVA NNP cord-023095-4dannjjm 1737 18 ) ) -RRB- cord-023095-4dannjjm 1737 19 and and CC cord-023095-4dannjjm 1737 20 non non JJ cord-023095-4dannjjm 1737 21 - - JJ cord-023095-4dannjjm 1737 22 normally normally RB cord-023095-4dannjjm 1737 23 distributed distribute VBN cord-023095-4dannjjm 1737 24 data datum NNS cord-023095-4dannjjm 1737 25 were be VBD cord-023095-4dannjjm 1737 26 analyzed analyze VBN cord-023095-4dannjjm 1737 27 using use VBG cord-023095-4dannjjm 1737 28 Friedman Friedman NNP cord-023095-4dannjjm 1737 29 RM_ANOVA RM_ANOVA NNP cord-023095-4dannjjm 1737 30 on on IN cord-023095-4dannjjm 1737 31 ranks rank NNS cord-023095-4dannjjm 1737 32 . . . cord-023095-4dannjjm 1738 1 Significance significance NN cord-023095-4dannjjm 1738 2 was be VBD cord-023095-4dannjjm 1738 3 set set VBN cord-023095-4dannjjm 1738 4 at at IN cord-023095-4dannjjm 1738 5 P p NN cord-023095-4dannjjm 1738 6 o o NN cord-023095-4dannjjm 1738 7 0.05 0.05 CD cord-023095-4dannjjm 1738 8 . . . cord-023095-4dannjjm 1739 1 No no DT cord-023095-4dannjjm 1739 2 adverse adverse JJ cord-023095-4dannjjm 1739 3 effects effect NNS cord-023095-4dannjjm 1739 4 were be VBD cord-023095-4dannjjm 1739 5 observed observe VBN cord-023095-4dannjjm 1739 6 during during IN cord-023095-4dannjjm 1739 7 the the DT cord-023095-4dannjjm 1739 8 study study NN cord-023095-4dannjjm 1739 9 period period NN cord-023095-4dannjjm 1739 10 . . . cord-023095-4dannjjm 1740 1 Plasma plasma NN cord-023095-4dannjjm 1740 2 quinapril quinapril NN cord-023095-4dannjjm 1740 3 concentrations concentration NNS cord-023095-4dannjjm 1740 4 were be VBD cord-023095-4dannjjm 1740 5 low low JJ cord-023095-4dannjjm 1740 6 and and CC cord-023095-4dannjjm 1740 7 rapidly rapidly RB cord-023095-4dannjjm 1740 8 declined decline VBD cord-023095-4dannjjm 1740 9 after after IN cord-023095-4dannjjm 1740 10 IV IV NNP cord-023095-4dannjjm 1740 11 administration administration NN cord-023095-4dannjjm 1740 12 . . . cord-023095-4dannjjm 1741 1 Quinaprilat Quinaprilat NNP cord-023095-4dannjjm 1741 2 concentrations concentration NNS cord-023095-4dannjjm 1741 3 were be VBD cord-023095-4dannjjm 1741 4 below below IN cord-023095-4dannjjm 1741 5 the the DT cord-023095-4dannjjm 1741 6 limit limit NN cord-023095-4dannjjm 1741 7 of of IN cord-023095-4dannjjm 1741 8 quantification quantification NN cord-023095-4dannjjm 1741 9 ( ( -LRB- cord-023095-4dannjjm 1741 10 0.1 0.1 CD cord-023095-4dannjjm 1741 11 mg mg NNP cord-023095-4dannjjm 1741 12 / / SYM cord-023095-4dannjjm 1741 13 mL mL NNP cord-023095-4dannjjm 1741 14 ) ) -RRB- cord-023095-4dannjjm 1741 15 . . . cord-023095-4dannjjm 1742 1 ACE ace NN cord-023095-4dannjjm 1742 2 activity activity NN cord-023095-4dannjjm 1742 3 was be VBD cord-023095-4dannjjm 1742 4 significantly significantly RB cord-023095-4dannjjm 1742 5 decreased decrease VBN cord-023095-4dannjjm 1742 6 from from IN cord-023095-4dannjjm 1742 7 baseline baseline NN cord-023095-4dannjjm 1742 8 at at IN cord-023095-4dannjjm 1742 9 0.5 0.5 CD cord-023095-4dannjjm 1742 10 and and CC cord-023095-4dannjjm 1742 11 1 1 CD cord-023095-4dannjjm 1742 12 hour hour NN cord-023095-4dannjjm 1742 13 after after IN cord-023095-4dannjjm 1742 14 IV IV NNP cord-023095-4dannjjm 1742 15 dosing dose VBG cord-023095-4dannjjm 1742 16 and and CC cord-023095-4dannjjm 1742 17 at at IN cord-023095-4dannjjm 1742 18 all all DT cord-023095-4dannjjm 1742 19 timepoints timepoint NNS cord-023095-4dannjjm 1742 20 after after IN cord-023095-4dannjjm 1742 21 oral oral JJ cord-023095-4dannjjm 1742 22 dosing dosing NN cord-023095-4dannjjm 1742 23 . . . cord-023095-4dannjjm 1743 1 Maximum maximum JJ cord-023095-4dannjjm 1743 2 % % NN cord-023095-4dannjjm 1743 3 ACE ace NN cord-023095-4dannjjm 1743 4 inhibition inhibition NN cord-023095-4dannjjm 1743 5 was be VBD cord-023095-4dannjjm 1743 6 72 72 CD cord-023095-4dannjjm 1743 7 , , , cord-023095-4dannjjm 1743 8 53 53 CD cord-023095-4dannjjm 1743 9 and and CC cord-023095-4dannjjm 1743 10 47 47 CD cord-023095-4dannjjm 1743 11 % % NN cord-023095-4dannjjm 1743 12 with with IN cord-023095-4dannjjm 1743 13 the the DT cord-023095-4dannjjm 1743 14 IV IV NNP cord-023095-4dannjjm 1743 15 , , , cord-023095-4dannjjm 1743 16 high high JJ cord-023095-4dannjjm 1743 17 and and CC cord-023095-4dannjjm 1743 18 low low JJ cord-023095-4dannjjm 1743 19 oral oral JJ cord-023095-4dannjjm 1743 20 doses dose NNS cord-023095-4dannjjm 1743 21 , , , cord-023095-4dannjjm 1743 22 respectively respectively RB cord-023095-4dannjjm 1743 23 . . . cord-023095-4dannjjm 1744 1 These these DT cord-023095-4dannjjm 1744 2 results result NNS cord-023095-4dannjjm 1744 3 suggest suggest VBP cord-023095-4dannjjm 1744 4 that that IN cord-023095-4dannjjm 1744 5 , , , cord-023095-4dannjjm 1744 6 despite despite IN cord-023095-4dannjjm 1744 7 low low JJ cord-023095-4dannjjm 1744 8 plasma plasma NN cord-023095-4dannjjm 1744 9 concentrations concentration NNS cord-023095-4dannjjm 1744 10 , , , cord-023095-4dannjjm 1744 11 quinapril quinapril NNP cord-023095-4dannjjm 1744 12 has have VBZ cord-023095-4dannjjm 1744 13 sufficient sufficient JJ cord-023095-4dannjjm 1744 14 oral oral JJ cord-023095-4dannjjm 1744 15 absorption absorption NN cord-023095-4dannjjm 1744 16 and and CC cord-023095-4dannjjm 1744 17 results result NNS cord-023095-4dannjjm 1744 18 in in IN cord-023095-4dannjjm 1744 19 inhibition inhibition NN cord-023095-4dannjjm 1744 20 of of IN cord-023095-4dannjjm 1744 21 ACE ace NN cord-023095-4dannjjm 1744 22 in in IN cord-023095-4dannjjm 1744 23 healthy healthy JJ cord-023095-4dannjjm 1744 24 horses horse NNS cord-023095-4dannjjm 1744 25 . . . cord-023095-4dannjjm 1745 1 Controlled controlled JJ cord-023095-4dannjjm 1745 2 studies study NNS cord-023095-4dannjjm 1745 3 in in IN cord-023095-4dannjjm 1745 4 clinically clinically RB cord-023095-4dannjjm 1745 5 affected affected JJ cord-023095-4dannjjm 1745 6 horses horse NNS cord-023095-4dannjjm 1745 7 are be VBP cord-023095-4dannjjm 1745 8 indicated indicate VBN cord-023095-4dannjjm 1745 9 . . . cord-023095-4dannjjm 1746 1 This this DT cord-023095-4dannjjm 1746 2 study study NN cord-023095-4dannjjm 1746 3 determined determine VBD cord-023095-4dannjjm 1746 4 the the DT cord-023095-4dannjjm 1746 5 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 1746 6 profile profile NN cord-023095-4dannjjm 1746 7 of of IN cord-023095-4dannjjm 1746 8 firocoxib firocoxib NN cord-023095-4dannjjm 1746 9 in in IN cord-023095-4dannjjm 1746 10 healthy healthy JJ cord-023095-4dannjjm 1746 11 neonatal neonatal JJ cord-023095-4dannjjm 1746 12 foals foal NNS cord-023095-4dannjjm 1746 13 . . . cord-023095-4dannjjm 1747 1 Foals foal NNS cord-023095-4dannjjm 1747 2 are be VBP cord-023095-4dannjjm 1747 3 more more RBR cord-023095-4dannjjm 1747 4 sensitive sensitive JJ cord-023095-4dannjjm 1747 5 to to IN cord-023095-4dannjjm 1747 6 the the DT cord-023095-4dannjjm 1747 7 side side JJ cord-023095-4dannjjm 1747 8 effects effect NNS cord-023095-4dannjjm 1747 9 of of IN cord-023095-4dannjjm 1747 10 NSAID NSAID NNP cord-023095-4dannjjm 1747 11 , , , cord-023095-4dannjjm 1747 12 primarily primarily RB cord-023095-4dannjjm 1747 13 due due JJ cord-023095-4dannjjm 1747 14 to to IN cord-023095-4dannjjm 1747 15 immature immature JJ cord-023095-4dannjjm 1747 16 renal renal JJ cord-023095-4dannjjm 1747 17 clearance clearance NN cord-023095-4dannjjm 1747 18 mechanisms mechanism NNS cord-023095-4dannjjm 1747 19 and and CC cord-023095-4dannjjm 1747 20 ulcerogenic ulcerogenic JJ cord-023095-4dannjjm 1747 21 effects effect NNS cord-023095-4dannjjm 1747 22 on on IN cord-023095-4dannjjm 1747 23 gastric gastric JJ cord-023095-4dannjjm 1747 24 mucosa mucosa NN cord-023095-4dannjjm 1747 25 . . . cord-023095-4dannjjm 1748 1 Firocoxib Firocoxib NNP cord-023095-4dannjjm 1748 2 , , , cord-023095-4dannjjm 1748 3 a a DT cord-023095-4dannjjm 1748 4 novel novel NN cord-023095-4dannjjm 1748 5 , , , cord-023095-4dannjjm 1748 6 second second JJ cord-023095-4dannjjm 1748 7 generation generation NN cord-023095-4dannjjm 1748 8 NSAID NSAID NNP cord-023095-4dannjjm 1748 9 , , , cord-023095-4dannjjm 1748 10 is be VBZ cord-023095-4dannjjm 1748 11 reported report VBN cord-023095-4dannjjm 1748 12 to to TO cord-023095-4dannjjm 1748 13 have have VB cord-023095-4dannjjm 1748 14 reduced reduce VBN cord-023095-4dannjjm 1748 15 side side NN cord-023095-4dannjjm 1748 16 effects effect NNS cord-023095-4dannjjm 1748 17 due due IN cord-023095-4dannjjm 1748 18 to to IN cord-023095-4dannjjm 1748 19 COX-2 cox-2 JJ cord-023095-4dannjjm 1748 20 selectivity selectivity NN cord-023095-4dannjjm 1748 21 . . . cord-023095-4dannjjm 1749 1 The the DT cord-023095-4dannjjm 1749 2 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 1749 3 profile profile NN cord-023095-4dannjjm 1749 4 of of IN cord-023095-4dannjjm 1749 5 firocoxib firocoxib NN cord-023095-4dannjjm 1749 6 in in IN cord-023095-4dannjjm 1749 7 neonates neonate NNS cord-023095-4dannjjm 1749 8 has have VBZ cord-023095-4dannjjm 1749 9 not not RB cord-023095-4dannjjm 1749 10 been be VBN cord-023095-4dannjjm 1749 11 established establish VBN cord-023095-4dannjjm 1749 12 . . . cord-023095-4dannjjm 1750 1 We -PRON- PRP cord-023095-4dannjjm 1750 2 hypothesized hypothesize VBD cord-023095-4dannjjm 1750 3 that that IN cord-023095-4dannjjm 1750 4 firocoxib firocoxib NNP cord-023095-4dannjjm 1750 5 given give VBN cord-023095-4dannjjm 1750 6 PO po NN cord-023095-4dannjjm 1750 7 to to IN cord-023095-4dannjjm 1750 8 neonatal neonatal JJ cord-023095-4dannjjm 1750 9 foals foal NNS cord-023095-4dannjjm 1750 10 would would MD cord-023095-4dannjjm 1750 11 achieve achieve VB cord-023095-4dannjjm 1750 12 therapeutic therapeutic JJ cord-023095-4dannjjm 1750 13 concentrations concentration NNS cord-023095-4dannjjm 1750 14 in in IN cord-023095-4dannjjm 1750 15 plasma plasma NN cord-023095-4dannjjm 1750 16 . . . cord-023095-4dannjjm 1751 1 Seven seven CD cord-023095-4dannjjm 1751 2 healthy healthy JJ cord-023095-4dannjjm 1751 3 foals foal NNS cord-023095-4dannjjm 1751 4 of of IN cord-023095-4dannjjm 1751 5 mixed mixed JJ cord-023095-4dannjjm 1751 6 gender gender NN cord-023095-4dannjjm 1751 7 were be VBD cord-023095-4dannjjm 1751 8 administered administer VBN cord-023095-4dannjjm 1752 1 0.1 0.1 CD cord-023095-4dannjjm 1752 2 mg mg NNP cord-023095-4dannjjm 1752 3 / / SYM cord-023095-4dannjjm 1752 4 kg kg NNP cord-023095-4dannjjm 1752 5 firocoxib firocoxib NN cord-023095-4dannjjm 1752 6 PO PO NNP cord-023095-4dannjjm 1753 1 q24h q24h NNS cord-023095-4dannjjm 1753 2 for for IN cord-023095-4dannjjm 1753 3 nine nine CD cord-023095-4dannjjm 1753 4 consecutive consecutive JJ cord-023095-4dannjjm 1753 5 days day NNS cord-023095-4dannjjm 1753 6 , , , cord-023095-4dannjjm 1754 1 commencing commence VBG cord-023095-4dannjjm 1754 2 at at IN cord-023095-4dannjjm 1754 3 36h 36h CD cord-023095-4dannjjm 1754 4 old old JJ cord-023095-4dannjjm 1754 5 . . . cord-023095-4dannjjm 1755 1 Blood blood NN cord-023095-4dannjjm 1755 2 was be VBD cord-023095-4dannjjm 1755 3 collected collect VBN cord-023095-4dannjjm 1755 4 for for IN cord-023095-4dannjjm 1755 5 firocoxib firocoxib NN cord-023095-4dannjjm 1755 6 analysis analysis NN cord-023095-4dannjjm 1755 7 at at IN cord-023095-4dannjjm 1755 8 0 0 CD cord-023095-4dannjjm 1755 9 ( ( -LRB- cord-023095-4dannjjm 1755 10 dose dose NN cord-023095-4dannjjm 1755 11 # # $ cord-023095-4dannjjm 1755 12 1 1 CD cord-023095-4dannjjm 1755 13 only only RB cord-023095-4dannjjm 1755 14 ) ) -RRB- cord-023095-4dannjjm 1755 15 , , , cord-023095-4dannjjm 1755 16 0.25 0.25 CD cord-023095-4dannjjm 1755 17 , , , cord-023095-4dannjjm 1755 18 0.5 0.5 CD cord-023095-4dannjjm 1755 19 , , , cord-023095-4dannjjm 1755 20 1 1 CD cord-023095-4dannjjm 1755 21 , , , cord-023095-4dannjjm 1755 22 2 2 CD cord-023095-4dannjjm 1755 23 , , , cord-023095-4dannjjm 1755 24 4 4 CD cord-023095-4dannjjm 1755 25 , , , cord-023095-4dannjjm 1755 26 8 8 CD cord-023095-4dannjjm 1755 27 , , , cord-023095-4dannjjm 1755 28 16 16 CD cord-023095-4dannjjm 1755 29 and and CC cord-023095-4dannjjm 1755 30 24h 24h NNS cord-023095-4dannjjm 1755 31 after after IN cord-023095-4dannjjm 1755 32 doses dose NNS cord-023095-4dannjjm 1755 33 # # $ cord-023095-4dannjjm 1755 34 1 1 CD cord-023095-4dannjjm 1755 35 , , , cord-023095-4dannjjm 1755 36 5 5 CD cord-023095-4dannjjm 1755 37 and and CC cord-023095-4dannjjm 1755 38 9 9 CD cord-023095-4dannjjm 1755 39 . . . cord-023095-4dannjjm 1756 1 For for IN cord-023095-4dannjjm 1756 2 all all DT cord-023095-4dannjjm 1756 3 other other JJ cord-023095-4dannjjm 1756 4 doses dose NNS cord-023095-4dannjjm 1756 5 ( ( -LRB- cord-023095-4dannjjm 1756 6 2 2 CD cord-023095-4dannjjm 1756 7 , , , cord-023095-4dannjjm 1756 8 3 3 CD cord-023095-4dannjjm 1756 9 , , , cord-023095-4dannjjm 1756 10 4 4 CD cord-023095-4dannjjm 1756 11 , , , cord-023095-4dannjjm 1756 12 6 6 CD cord-023095-4dannjjm 1756 13 , , , cord-023095-4dannjjm 1756 14 7 7 CD cord-023095-4dannjjm 1756 15 and and CC cord-023095-4dannjjm 1756 16 8) 8) NN cord-023095-4dannjjm 1756 17 blood blood NN cord-023095-4dannjjm 1756 18 was be VBD cord-023095-4dannjjm 1756 19 collected collect VBN cord-023095-4dannjjm 1756 20 immediately immediately RB cord-023095-4dannjjm 1756 21 prior prior RB cord-023095-4dannjjm 1756 22 to to IN cord-023095-4dannjjm 1756 23 the the DT cord-023095-4dannjjm 1756 24 next next JJ cord-023095-4dannjjm 1756 25 dose dose NN cord-023095-4dannjjm 1756 26 ( ( -LRB- cord-023095-4dannjjm 1756 27 24h 24h NNS cord-023095-4dannjjm 1756 28 trough trough NN cord-023095-4dannjjm 1756 29 ) ) -RRB- cord-023095-4dannjjm 1756 30 . . . cord-023095-4dannjjm 1757 1 Elimination elimination NN cord-023095-4dannjjm 1757 2 samples sample NNS cord-023095-4dannjjm 1757 3 were be VBD cord-023095-4dannjjm 1757 4 collected collect VBN cord-023095-4dannjjm 1757 5 after after IN cord-023095-4dannjjm 1757 6 dose dose NN cord-023095-4dannjjm 1757 7 # # NN cord-023095-4dannjjm 1757 8 9 9 CD cord-023095-4dannjjm 1757 9 . . . cord-023095-4dannjjm 1758 1 Plasma plasma NN cord-023095-4dannjjm 1758 2 was be VBD cord-023095-4dannjjm 1758 3 stored store VBN cord-023095-4dannjjm 1758 4 at at IN cord-023095-4dannjjm 1758 5 À801C À801C NNPS cord-023095-4dannjjm 1758 6 until until IN cord-023095-4dannjjm 1758 7 analysis analysis NN cord-023095-4dannjjm 1758 8 . . . cord-023095-4dannjjm 1759 1 Physical physical JJ cord-023095-4dannjjm 1759 2 examinations examination NNS cord-023095-4dannjjm 1759 3 were be VBD cord-023095-4dannjjm 1759 4 performed perform VBN cord-023095-4dannjjm 1759 5 on on IN cord-023095-4dannjjm 1759 6 foals foal NNS cord-023095-4dannjjm 1759 7 daily daily JJ cord-023095-4dannjjm 1759 8 and and CC cord-023095-4dannjjm 1759 9 body body NN cord-023095-4dannjjm 1759 10 weight weight NN cord-023095-4dannjjm 1759 11 obtained obtain VBD cord-023095-4dannjjm 1759 12 every every DT cord-023095-4dannjjm 1759 13 two two CD cord-023095-4dannjjm 1759 14 days day NNS cord-023095-4dannjjm 1759 15 during during IN cord-023095-4dannjjm 1759 16 the the DT cord-023095-4dannjjm 1759 17 sampling sampling NN cord-023095-4dannjjm 1759 18 period period NN cord-023095-4dannjjm 1759 19 . . . cord-023095-4dannjjm 1760 1 Analysis analysis NN cord-023095-4dannjjm 1760 2 of of IN cord-023095-4dannjjm 1760 3 plasma plasma NN cord-023095-4dannjjm 1760 4 samples sample NNS cord-023095-4dannjjm 1760 5 by by IN cord-023095-4dannjjm 1760 6 liquid liquid JJ cord-023095-4dannjjm 1760 7 chromatography chromatography NN cord-023095-4dannjjm 1760 8 - - HYPH cord-023095-4dannjjm 1760 9 mass mass NN cord-023095-4dannjjm 1760 10 spectrometry spectrometry NN cord-023095-4dannjjm 1760 11 revealed reveal VBN cord-023095-4dannjjm 1760 12 firocoxib firocoxib NNP cord-023095-4dannjjm 1760 13 was be VBD cord-023095-4dannjjm 1760 14 rapidly rapidly RB cord-023095-4dannjjm 1760 15 absorbed absorb VBN cord-023095-4dannjjm 1760 16 . . . cord-023095-4dannjjm 1761 1 After after IN cord-023095-4dannjjm 1761 2 the the DT cord-023095-4dannjjm 1761 3 initial initial JJ cord-023095-4dannjjm 1761 4 dose dose NN cord-023095-4dannjjm 1761 5 , , , cord-023095-4dannjjm 1761 6 a a DT cord-023095-4dannjjm 1761 7 maximum maximum JJ cord-023095-4dannjjm 1761 8 plasma plasma NN cord-023095-4dannjjm 1761 9 concentration concentration NN cord-023095-4dannjjm 1761 10 was be VBD cord-023095-4dannjjm 1761 11 reached reach VBN cord-023095-4dannjjm 1761 12 in in IN cord-023095-4dannjjm 1761 13 30 30 CD cord-023095-4dannjjm 1761 14 min min NN cord-023095-4dannjjm 1761 15 , , , cord-023095-4dannjjm 1761 16 minimal minimal JJ cord-023095-4dannjjm 1761 17 accumulation accumulation NN cord-023095-4dannjjm 1761 18 after after IN cord-023095-4dannjjm 1761 19 repeat repeat NN cord-023095-4dannjjm 1761 20 dosing dosing NN cord-023095-4dannjjm 1761 21 occurred occur VBD cord-023095-4dannjjm 1761 22 and and CC cord-023095-4dannjjm 1761 23 steady steady JJ cord-023095-4dannjjm 1761 24 state state NN cord-023095-4dannjjm 1761 25 was be VBD cord-023095-4dannjjm 1761 26 obtained obtain VBN cord-023095-4dannjjm 1761 27 after after IN cord-023095-4dannjjm 1761 28 approximately approximately RB cord-023095-4dannjjm 1761 29 four four CD cord-023095-4dannjjm 1761 30 doses dose NNS cord-023095-4dannjjm 1761 31 . . . cord-023095-4dannjjm 1762 1 After after IN cord-023095-4dannjjm 1762 2 the the DT cord-023095-4dannjjm 1762 3 final final JJ cord-023095-4dannjjm 1762 4 dose dose NN cord-023095-4dannjjm 1762 5 , , , cord-023095-4dannjjm 1762 6 plasma plasma NN cord-023095-4dannjjm 1762 7 drug drug NN cord-023095-4dannjjm 1762 8 concentration concentration NN cord-023095-4dannjjm 1762 9 decreased decrease VBD cord-023095-4dannjjm 1762 10 in in IN cord-023095-4dannjjm 1762 11 a a DT cord-023095-4dannjjm 1762 12 linear linear JJ cord-023095-4dannjjm 1762 13 manner manner NN cord-023095-4dannjjm 1762 14 with with IN cord-023095-4dannjjm 1762 15 an an DT cord-023095-4dannjjm 1762 16 estimated estimate VBN cord-023095-4dannjjm 1762 17 terminal terminal NN cord-023095-4dannjjm 1762 18 t1/2 t1/2 NN cord-023095-4dannjjm 1762 19 of of IN cord-023095-4dannjjm 1762 20 11h 11h NNS cord-023095-4dannjjm 1762 21 . . . cord-023095-4dannjjm 1763 1 Seventy seventy CD cord-023095-4dannjjm 1763 2 - - HYPH cord-023095-4dannjjm 1763 3 two two CD cord-023095-4dannjjm 1763 4 hours hour NNS cord-023095-4dannjjm 1763 5 after after IN cord-023095-4dannjjm 1763 6 the the DT cord-023095-4dannjjm 1763 7 final final JJ cord-023095-4dannjjm 1763 8 dose dose NN cord-023095-4dannjjm 1763 9 , , , cord-023095-4dannjjm 1763 10 firocoxib firocoxib NNP cord-023095-4dannjjm 1763 11 was be VBD cord-023095-4dannjjm 1763 12 not not RB cord-023095-4dannjjm 1763 13 detectable detectable JJ cord-023095-4dannjjm 1764 1 ( ( -LRB- cord-023095-4dannjjm 1764 2 o o UH cord-023095-4dannjjm 1764 3 2ng 2ng NN cord-023095-4dannjjm 1764 4 / / SYM cord-023095-4dannjjm 1764 5 mL ml NN cord-023095-4dannjjm 1764 6 ) ) -RRB- cord-023095-4dannjjm 1764 7 . . . cord-023095-4dannjjm 1765 1 Erythrocytosis Erythrocytosis NNP cord-023095-4dannjjm 1765 2 is be VBZ cord-023095-4dannjjm 1765 3 reportedly reportedly RB cord-023095-4dannjjm 1765 4 a a DT cord-023095-4dannjjm 1765 5 rare rare JJ cord-023095-4dannjjm 1765 6 finding finding NN cord-023095-4dannjjm 1765 7 associated associate VBN cord-023095-4dannjjm 1765 8 with with IN cord-023095-4dannjjm 1765 9 hepatocellular hepatocellular JJ cord-023095-4dannjjm 1765 10 carcinoma carcinoma NN cord-023095-4dannjjm 1765 11 in in IN cord-023095-4dannjjm 1765 12 horses horse NNS cord-023095-4dannjjm 1765 13 . . . cord-023095-4dannjjm 1766 1 The the DT cord-023095-4dannjjm 1766 2 purpose purpose NN cord-023095-4dannjjm 1766 3 of of IN cord-023095-4dannjjm 1766 4 this this DT cord-023095-4dannjjm 1766 5 study study NN cord-023095-4dannjjm 1766 6 was be VBD cord-023095-4dannjjm 1766 7 to to TO cord-023095-4dannjjm 1766 8 determine determine VB cord-023095-4dannjjm 1766 9 the the DT cord-023095-4dannjjm 1766 10 relative relative JJ cord-023095-4dannjjm 1766 11 frequency frequency NN cord-023095-4dannjjm 1766 12 of of IN cord-023095-4dannjjm 1766 13 erythrocytosis erythrocytosis NN cord-023095-4dannjjm 1766 14 and and CC cord-023095-4dannjjm 1766 15 the the DT cord-023095-4dannjjm 1766 16 clinicopathologic clinicopathologic JJ cord-023095-4dannjjm 1766 17 abnormalities abnormality NNS cord-023095-4dannjjm 1766 18 and and CC cord-023095-4dannjjm 1766 19 hepatic hepatic JJ cord-023095-4dannjjm 1766 20 histopathology histopathology NN cord-023095-4dannjjm 1766 21 associated associate VBN cord-023095-4dannjjm 1766 22 with with IN cord-023095-4dannjjm 1766 23 erythrocytosis erythrocytosis NN cord-023095-4dannjjm 1766 24 in in IN cord-023095-4dannjjm 1766 25 horses horse NNS cord-023095-4dannjjm 1766 26 with with IN cord-023095-4dannjjm 1766 27 liver liver NN cord-023095-4dannjjm 1766 28 disease disease NN cord-023095-4dannjjm 1766 29 . . . cord-023095-4dannjjm 1767 1 Ninety ninety CD cord-023095-4dannjjm 1767 2 - - HYPH cord-023095-4dannjjm 1767 3 seven seven CD cord-023095-4dannjjm 1767 4 horses horse NNS cord-023095-4dannjjm 1767 5 aged age VBN cord-023095-4dannjjm 1767 6 ! ! . cord-023095-4dannjjm 1768 1 1 1 CD cord-023095-4dannjjm 1768 2 year year NN cord-023095-4dannjjm 1768 3 with with IN cord-023095-4dannjjm 1768 4 clinicopathologic clinicopathologic JJ cord-023095-4dannjjm 1768 5 or or CC cord-023095-4dannjjm 1768 6 clinical clinical JJ cord-023095-4dannjjm 1768 7 signs sign NNS cord-023095-4dannjjm 1768 8 of of IN cord-023095-4dannjjm 1768 9 liver liver NN cord-023095-4dannjjm 1768 10 disease disease NN cord-023095-4dannjjm 1768 11 , , , cord-023095-4dannjjm 1768 12 a a DT cord-023095-4dannjjm 1768 13 complete complete JJ cord-023095-4dannjjm 1768 14 blood blood NN cord-023095-4dannjjm 1768 15 count count NN cord-023095-4dannjjm 1768 16 ( ( -LRB- cord-023095-4dannjjm 1768 17 CBC CBC NNP cord-023095-4dannjjm 1768 18 ) ) -RRB- cord-023095-4dannjjm 1768 19 , , , cord-023095-4dannjjm 1768 20 and and CC cord-023095-4dannjjm 1768 21 hepatic hepatic JJ cord-023095-4dannjjm 1768 22 histopathology histopathology NN cord-023095-4dannjjm 1768 23 were be VBD cord-023095-4dannjjm 1768 24 included include VBN cord-023095-4dannjjm 1768 25 . . . cord-023095-4dannjjm 1769 1 Information information NN cord-023095-4dannjjm 1769 2 on on IN cord-023095-4dannjjm 1769 3 CBC CBC NNP cord-023095-4dannjjm 1769 4 , , , cord-023095-4dannjjm 1769 5 biochemical biochemical JJ cord-023095-4dannjjm 1769 6 variables variable NNS cord-023095-4dannjjm 1769 7 , , , cord-023095-4dannjjm 1769 8 and and CC cord-023095-4dannjjm 1769 9 hepatic hepatic JJ cord-023095-4dannjjm 1769 10 histopathology histopathology NN cord-023095-4dannjjm 1769 11 was be VBD cord-023095-4dannjjm 1769 12 collected collect VBN cord-023095-4dannjjm 1769 13 from from IN cord-023095-4dannjjm 1769 14 records record NNS cord-023095-4dannjjm 1769 15 . . . cord-023095-4dannjjm 1770 1 Data datum NNS cord-023095-4dannjjm 1770 2 from from IN cord-023095-4dannjjm 1770 3 horses horse NNS cord-023095-4dannjjm 1770 4 with with IN cord-023095-4dannjjm 1770 5 erythrocytosis erythrocytosis NN cord-023095-4dannjjm 1770 6 ( ( -LRB- cord-023095-4dannjjm 1770 7 packed pack VBN cord-023095-4dannjjm 1770 8 cell cell NN cord-023095-4dannjjm 1770 9 volume volume NN cord-023095-4dannjjm 1770 10 4 4 CD cord-023095-4dannjjm 1770 11 45 45 CD cord-023095-4dannjjm 1770 12 % % NN cord-023095-4dannjjm 1770 13 ) ) -RRB- cord-023095-4dannjjm 1770 14 were be VBD cord-023095-4dannjjm 1770 15 compared compare VBN cord-023095-4dannjjm 1770 16 to to IN cord-023095-4dannjjm 1770 17 those those DT cord-023095-4dannjjm 1770 18 without without IN cord-023095-4dannjjm 1770 19 using use VBG cord-023095-4dannjjm 1770 20 the the DT cord-023095-4dannjjm 1770 21 Mann Mann NNP cord-023095-4dannjjm 1770 22 - - HYPH cord-023095-4dannjjm 1770 23 Whitney Whitney NNP cord-023095-4dannjjm 1770 24 rank rank NN cord-023095-4dannjjm 1770 25 sum sum NN cord-023095-4dannjjm 1770 26 test test NN cord-023095-4dannjjm 1770 27 with with IN cord-023095-4dannjjm 1770 28 significance significance NN cord-023095-4dannjjm 1770 29 set set VBN cord-023095-4dannjjm 1770 30 at at IN cord-023095-4dannjjm 1770 31 p p NN cord-023095-4dannjjm 1770 32 o o NN cord-023095-4dannjjm 1770 33 0.05 0.05 CD cord-023095-4dannjjm 1770 34 . . . cord-023095-4dannjjm 1771 1 There there EX cord-023095-4dannjjm 1771 2 were be VBD cord-023095-4dannjjm 1771 3 no no DT cord-023095-4dannjjm 1771 4 differences difference NNS cord-023095-4dannjjm 1771 5 between between IN cord-023095-4dannjjm 1771 6 groups group NNS cord-023095-4dannjjm 1771 7 in in IN cord-023095-4dannjjm 1771 8 white white JJ cord-023095-4dannjjm 1771 9 blood blood NN cord-023095-4dannjjm 1771 10 cell cell NN cord-023095-4dannjjm 1771 11 count count NN cord-023095-4dannjjm 1771 12 , , , cord-023095-4dannjjm 1771 13 gamma gamma NN cord-023095-4dannjjm 1771 14 - - HYPH cord-023095-4dannjjm 1771 15 glutamyl glutamyl JJ cord-023095-4dannjjm 1771 16 transferase transferase NN cord-023095-4dannjjm 1771 17 , , , cord-023095-4dannjjm 1771 18 sorbitol sorbitol NN cord-023095-4dannjjm 1771 19 dehydrogenase dehydrogenase NN cord-023095-4dannjjm 1771 20 , , , cord-023095-4dannjjm 1771 21 aspartate aspartate NN cord-023095-4dannjjm 1771 22 aminotransferase aminotransferase NN cord-023095-4dannjjm 1771 23 , , , cord-023095-4dannjjm 1771 24 and and CC cord-023095-4dannjjm 1771 25 alkaline alkaline JJ cord-023095-4dannjjm 1771 26 phosphatase phosphatase NN cord-023095-4dannjjm 1771 27 activities activity NNS cord-023095-4dannjjm 1771 28 , , , cord-023095-4dannjjm 1771 29 total total JJ cord-023095-4dannjjm 1771 30 protein protein NN cord-023095-4dannjjm 1771 31 , , , cord-023095-4dannjjm 1771 32 albumin albumin NN cord-023095-4dannjjm 1771 33 , , , cord-023095-4dannjjm 1771 34 globulin globulin NN cord-023095-4dannjjm 1771 35 , , , cord-023095-4dannjjm 1771 36 blood blood NN cord-023095-4dannjjm 1771 37 urea urea NN cord-023095-4dannjjm 1771 38 nitrogen nitrogen NN cord-023095-4dannjjm 1771 39 , , , cord-023095-4dannjjm 1771 40 or or CC cord-023095-4dannjjm 1771 41 glucose glucose NN cord-023095-4dannjjm 1771 42 concentrations concentration NNS cord-023095-4dannjjm 1771 43 . . . cord-023095-4dannjjm 1772 1 Fibrosis fibrosis NN cord-023095-4dannjjm 1772 2 ( ( -LRB- cord-023095-4dannjjm 1772 3 64 64 CD cord-023095-4dannjjm 1772 4 % % NN cord-023095-4dannjjm 1772 5 ) ) -RRB- cord-023095-4dannjjm 1772 6 , , , cord-023095-4dannjjm 1772 7 biliary biliary JJ cord-023095-4dannjjm 1772 8 hyperplasia hyperplasia NN cord-023095-4dannjjm 1772 9 ( ( -LRB- cord-023095-4dannjjm 1772 10 56 56 CD cord-023095-4dannjjm 1772 11 % % NN cord-023095-4dannjjm 1772 12 ) ) -RRB- cord-023095-4dannjjm 1772 13 , , , cord-023095-4dannjjm 1772 14 inflammatory inflammatory JJ cord-023095-4dannjjm 1772 15 infiltrate infiltrate NN cord-023095-4dannjjm 1772 16 ( ( -LRB- cord-023095-4dannjjm 1772 17 50 50 CD cord-023095-4dannjjm 1772 18 % % NN cord-023095-4dannjjm 1772 19 ) ) -RRB- cord-023095-4dannjjm 1772 20 , , . cord-023095-4dannjjm 1773 1 megalocytosis megalocytosis NNP cord-023095-4dannjjm 1773 2 ( ( -LRB- cord-023095-4dannjjm 1773 3 25 25 CD cord-023095-4dannjjm 1773 4 % % NN cord-023095-4dannjjm 1773 5 ) ) -RRB- cord-023095-4dannjjm 1773 6 , , , cord-023095-4dannjjm 1773 7 degeneration degeneration NN cord-023095-4dannjjm 1773 8 ( ( -LRB- cord-023095-4dannjjm 1773 9 25 25 CD cord-023095-4dannjjm 1773 10 % % NN cord-023095-4dannjjm 1773 11 ) ) -RRB- cord-023095-4dannjjm 1773 12 , , , cord-023095-4dannjjm 1773 13 necrosis necrosis NN cord-023095-4dannjjm 1773 14 ( ( -LRB- cord-023095-4dannjjm 1773 15 25 25 CD cord-023095-4dannjjm 1773 16 % % NN cord-023095-4dannjjm 1773 17 ) ) -RRB- cord-023095-4dannjjm 1774 1 , , , cord-023095-4dannjjm 1774 2 cholestasis cholestasis NN cord-023095-4dannjjm 1774 3 ( ( -LRB- cord-023095-4dannjjm 1774 4 25 25 CD cord-023095-4dannjjm 1774 5 % % NN cord-023095-4dannjjm 1774 6 ) ) -RRB- cord-023095-4dannjjm 1774 7 , , , cord-023095-4dannjjm 1774 8 anisocytosis anisocytosis NNP cord-023095-4dannjjm 1774 9 and and CC cord-023095-4dannjjm 1774 10 anisokaryosis anisokaryosis NNP cord-023095-4dannjjm 1774 11 ( ( -LRB- cord-023095-4dannjjm 1774 12 11 11 CD cord-023095-4dannjjm 1774 13 % % NN cord-023095-4dannjjm 1774 14 ) ) -RRB- cord-023095-4dannjjm 1774 15 , , , cord-023095-4dannjjm 1774 16 and and CC cord-023095-4dannjjm 1774 17 lipidosis lipidosis NN cord-023095-4dannjjm 1774 18 ( ( -LRB- cord-023095-4dannjjm 1774 19 3 3 CD cord-023095-4dannjjm 1774 20 % % NN cord-023095-4dannjjm 1774 21 ) ) -RRB- cord-023095-4dannjjm 1774 22 were be VBD cord-023095-4dannjjm 1774 23 observed observe VBN cord-023095-4dannjjm 1774 24 in in IN cord-023095-4dannjjm 1774 25 livers liver NNS cord-023095-4dannjjm 1774 26 of of IN cord-023095-4dannjjm 1774 27 horses horse NNS cord-023095-4dannjjm 1774 28 with with IN cord-023095-4dannjjm 1774 29 erythrocytosis erythrocytosis NN cord-023095-4dannjjm 1774 30 . . . cord-023095-4dannjjm 1775 1 Neoplasia neoplasia NN cord-023095-4dannjjm 1775 2 ( ( -LRB- cord-023095-4dannjjm 1775 3 3 3 CD cord-023095-4dannjjm 1775 4 % % NN cord-023095-4dannjjm 1775 5 ) ) -RRB- cord-023095-4dannjjm 1775 6 was be VBD cord-023095-4dannjjm 1775 7 observed observe VBN cord-023095-4dannjjm 1775 8 rarely rarely RB cord-023095-4dannjjm 1775 9 . . . cord-023095-4dannjjm 1776 1 This this DT cord-023095-4dannjjm 1776 2 study study NN cord-023095-4dannjjm 1776 3 reports report VBZ cord-023095-4dannjjm 1776 4 a a DT cord-023095-4dannjjm 1776 5 high high JJ cord-023095-4dannjjm 1776 6 frequency frequency NN cord-023095-4dannjjm 1776 7 of of IN cord-023095-4dannjjm 1776 8 erythrocytosis erythrocytosis NN cord-023095-4dannjjm 1776 9 in in IN cord-023095-4dannjjm 1776 10 horses horse NNS cord-023095-4dannjjm 1776 11 with with IN cord-023095-4dannjjm 1776 12 liver liver NN cord-023095-4dannjjm 1776 13 disease disease NN cord-023095-4dannjjm 1776 14 . . . cord-023095-4dannjjm 1777 1 Erythrocytosis Erythrocytosis NNP cord-023095-4dannjjm 1777 2 is be VBZ cord-023095-4dannjjm 1777 3 associated associate VBN cord-023095-4dannjjm 1777 4 with with IN cord-023095-4dannjjm 1777 5 higher high JJR cord-023095-4dannjjm 1777 6 total total JJ cord-023095-4dannjjm 1777 7 bilirubin bilirubin NN cord-023095-4dannjjm 1777 8 and and CC cord-023095-4dannjjm 1777 9 serum serum NN cord-023095-4dannjjm 1777 10 bile bile NN cord-023095-4dannjjm 1777 11 acids acid NNS cord-023095-4dannjjm 1777 12 concentrations concentration NNS cord-023095-4dannjjm 1777 13 . . . cord-023095-4dannjjm 1778 1 Common common JJ cord-023095-4dannjjm 1778 2 histopathologic histopathologic JJ cord-023095-4dannjjm 1778 3 changes change NNS cord-023095-4dannjjm 1778 4 include include VBP cord-023095-4dannjjm 1778 5 fibrosis fibrosis NN cord-023095-4dannjjm 1778 6 , , , cord-023095-4dannjjm 1778 7 biliary biliary JJ cord-023095-4dannjjm 1778 8 hyperplasia hyperplasia NN cord-023095-4dannjjm 1778 9 , , , cord-023095-4dannjjm 1778 10 and and CC cord-023095-4dannjjm 1778 11 inflammatory inflammatory JJ cord-023095-4dannjjm 1778 12 infiltrate infiltrate NN cord-023095-4dannjjm 1778 13 . . . cord-023095-4dannjjm 1779 1 Hepatic hepatic JJ cord-023095-4dannjjm 1779 2 neoplasia neoplasia NN cord-023095-4dannjjm 1779 3 was be VBD cord-023095-4dannjjm 1779 4 rare rare JJ cord-023095-4dannjjm 1779 5 . . . cord-023095-4dannjjm 1780 1 This this DT cord-023095-4dannjjm 1780 2 study study NN cord-023095-4dannjjm 1780 3 was be VBD cord-023095-4dannjjm 1780 4 performed perform VBN cord-023095-4dannjjm 1780 5 to to TO cord-023095-4dannjjm 1780 6 determine determine VB cord-023095-4dannjjm 1780 7 if if IN cord-023095-4dannjjm 1780 8 horses horse NNS cord-023095-4dannjjm 1780 9 diagnosed diagnose VBN cord-023095-4dannjjm 1780 10 with with IN cord-023095-4dannjjm 1780 11 equine equine JJ cord-023095-4dannjjm 1780 12 proliferative proliferative FW cord-023095-4dannjjm 1780 13 enteropathy enteropathy NNP cord-023095-4dannjjm 1780 14 ( ( -LRB- cord-023095-4dannjjm 1780 15 EPE EPE NNP cord-023095-4dannjjm 1780 16 ) ) -RRB- cord-023095-4dannjjm 1780 17 from from IN cord-023095-4dannjjm 1780 18 Lawsonia Lawsonia NNP cord-023095-4dannjjm 1780 19 intracellularis intracellularis . cord-023095-4dannjjm 1780 20 ( ( -LRB- cord-023095-4dannjjm 1780 21 LI LI NNP cord-023095-4dannjjm 1780 22 ) ) -RRB- cord-023095-4dannjjm 1780 23 infection infection NN cord-023095-4dannjjm 1780 24 had have VBD cord-023095-4dannjjm 1780 25 long long JJ cord-023095-4dannjjm 1780 26 term term NN cord-023095-4dannjjm 1780 27 effects effect NNS cord-023095-4dannjjm 1780 28 from from IN cord-023095-4dannjjm 1780 29 disease disease NN cord-023095-4dannjjm 1780 30 based base VBN cord-023095-4dannjjm 1780 31 on on IN cord-023095-4dannjjm 1780 32 their -PRON- PRP$ cord-023095-4dannjjm 1780 33 sale sale NN cord-023095-4dannjjm 1780 34 price price NN cord-023095-4dannjjm 1780 35 as as IN cord-023095-4dannjjm 1780 36 yearlings yearling NNS cord-023095-4dannjjm 1780 37 and and CC cord-023095-4dannjjm 1780 38 race race NN cord-023095-4dannjjm 1780 39 earnings earning NNS cord-023095-4dannjjm 1780 40 . . . cord-023095-4dannjjm 1781 1 A a DT cord-023095-4dannjjm 1781 2 retrospective retrospective JJ cord-023095-4dannjjm 1781 3 review review NN cord-023095-4dannjjm 1781 4 of of IN cord-023095-4dannjjm 1781 5 medical medical JJ cord-023095-4dannjjm 1781 6 records record NNS cord-023095-4dannjjm 1781 7 of of IN cord-023095-4dannjjm 1781 8 Thoroughbred thoroughbred JJ cord-023095-4dannjjm 1781 9 horses horse NNS cord-023095-4dannjjm 1781 10 that that WDT cord-023095-4dannjjm 1781 11 were be VBD cord-023095-4dannjjm 1781 12 treated treat VBN cord-023095-4dannjjm 1781 13 for for IN cord-023095-4dannjjm 1781 14 Lawsonia Lawsonia NNP cord-023095-4dannjjm 1781 15 intracellularis intracellularis JJ cord-023095-4dannjjm 1781 16 infection infection NN cord-023095-4dannjjm 1781 17 between between IN cord-023095-4dannjjm 1781 18 January January NNP cord-023095-4dannjjm 1781 19 1 1 CD cord-023095-4dannjjm 1781 20 , , , cord-023095-4dannjjm 1781 21 2002 2002 CD cord-023095-4dannjjm 1781 22 and and CC cord-023095-4dannjjm 1781 23 January January NNP cord-023095-4dannjjm 1781 24 31 31 CD cord-023095-4dannjjm 1781 25 , , , cord-023095-4dannjjm 1781 26 2008 2008 CD cord-023095-4dannjjm 1781 27 at at IN cord-023095-4dannjjm 1781 28 Hagyard Hagyard NNP cord-023095-4dannjjm 1781 29 Equine Equine NNP cord-023095-4dannjjm 1781 30 Medical Medical NNP cord-023095-4dannjjm 1781 31 Institute Institute NNP cord-023095-4dannjjm 1781 32 in in IN cord-023095-4dannjjm 1781 33 Lexington Lexington NNP cord-023095-4dannjjm 1781 34 , , , cord-023095-4dannjjm 1781 35 Kentucky Kentucky NNP cord-023095-4dannjjm 1781 36 was be VBD cord-023095-4dannjjm 1781 37 performed perform VBN cord-023095-4dannjjm 1781 38 . . . cord-023095-4dannjjm 1782 1 Three three CD cord-023095-4dannjjm 1782 2 criteria criterion NNS cord-023095-4dannjjm 1782 3 were be VBD cord-023095-4dannjjm 1782 4 used use VBN cord-023095-4dannjjm 1782 5 for for IN cord-023095-4dannjjm 1782 6 inclusion inclusion NN cord-023095-4dannjjm 1782 7 in in IN cord-023095-4dannjjm 1782 8 this this DT cord-023095-4dannjjm 1782 9 study study NN cord-023095-4dannjjm 1782 10 . . . cord-023095-4dannjjm 1783 1 First first RB cord-023095-4dannjjm 1783 2 , , , cord-023095-4dannjjm 1783 3 each each DT cord-023095-4dannjjm 1783 4 horse horse NN cord-023095-4dannjjm 1783 5 had have VBD cord-023095-4dannjjm 1783 6 presumptively presumptively RB cord-023095-4dannjjm 1783 7 been be VBN cord-023095-4dannjjm 1783 8 diagnosed diagnose VBN cord-023095-4dannjjm 1783 9 with with IN cord-023095-4dannjjm 1783 10 LI LI NNP cord-023095-4dannjjm 1783 11 based base VBN cord-023095-4dannjjm 1783 12 on on IN cord-023095-4dannjjm 1783 13 physical physical JJ cord-023095-4dannjjm 1783 14 examination examination NN cord-023095-4dannjjm 1783 15 findings finding NNS cord-023095-4dannjjm 1783 16 such such JJ cord-023095-4dannjjm 1783 17 as as IN cord-023095-4dannjjm 1783 18 ventral ventral JJ cord-023095-4dannjjm 1783 19 edema edema NN cord-023095-4dannjjm 1783 20 , , , cord-023095-4dannjjm 1783 21 diarrhea diarrhea NN cord-023095-4dannjjm 1783 22 , , , cord-023095-4dannjjm 1783 23 lethargy lethargy NN cord-023095-4dannjjm 1783 24 , , , cord-023095-4dannjjm 1783 25 or or CC cord-023095-4dannjjm 1783 26 poor poor JJ cord-023095-4dannjjm 1783 27 body body NN cord-023095-4dannjjm 1783 28 condition condition NN cord-023095-4dannjjm 1783 29 . . . cord-023095-4dannjjm 1784 1 Second second RB cord-023095-4dannjjm 1784 2 , , , cord-023095-4dannjjm 1784 3 horses horse NNS cord-023095-4dannjjm 1784 4 had have VBD cord-023095-4dannjjm 1784 5 hypoalbuminemia hypoalbuminemia NN cord-023095-4dannjjm 1784 6 of of IN cord-023095-4dannjjm 1784 7 less less JJR cord-023095-4dannjjm 1784 8 than than IN cord-023095-4dannjjm 1784 9 2.5 2.5 CD cord-023095-4dannjjm 1784 10 mg mg NNP cord-023095-4dannjjm 1784 11 / / SYM cord-023095-4dannjjm 1784 12 dL dl NN cord-023095-4dannjjm 1785 1 ( ( -LRB- cord-023095-4dannjjm 1785 2 normal normal JJ cord-023095-4dannjjm 1785 3 reference reference NN cord-023095-4dannjjm 1785 4 range range NN cord-023095-4dannjjm 1785 5 : : : cord-023095-4dannjjm 1785 6 3.4 3.4 CD cord-023095-4dannjjm 1785 7 - - SYM cord-023095-4dannjjm 1785 8 4.5 4.5 CD cord-023095-4dannjjm 1785 9 mg mg NNP cord-023095-4dannjjm 1785 10 / / SYM cord-023095-4dannjjm 1785 11 dL dl NN cord-023095-4dannjjm 1785 12 ) ) -RRB- cord-023095-4dannjjm 1785 13 . . . cord-023095-4dannjjm 1786 1 Third third RB cord-023095-4dannjjm 1786 2 , , , cord-023095-4dannjjm 1786 3 each each DT cord-023095-4dannjjm 1786 4 horse horse NN cord-023095-4dannjjm 1786 5 had have VBD cord-023095-4dannjjm 1786 6 a a DT cord-023095-4dannjjm 1786 7 positive positive JJ cord-023095-4dannjjm 1786 8 fecal fecal JJ cord-023095-4dannjjm 1786 9 polymerase polymerase NN cord-023095-4dannjjm 1786 10 chain chain NN cord-023095-4dannjjm 1786 11 reaction reaction NN cord-023095-4dannjjm 1786 12 ( ( -LRB- cord-023095-4dannjjm 1786 13 PCR PCR NNP cord-023095-4dannjjm 1786 14 ) ) -RRB- cord-023095-4dannjjm 1786 15 for for IN cord-023095-4dannjjm 1786 16 LI LI NNP cord-023095-4dannjjm 1786 17 , , , cord-023095-4dannjjm 1786 18 a a DT cord-023095-4dannjjm 1786 19 positive positive JJ cord-023095-4dannjjm 1786 20 serum serum NN cord-023095-4dannjjm 1786 21 immunoperoxidase immunoperoxidase NN cord-023095-4dannjjm 1786 22 monolayer monolayer NN cord-023095-4dannjjm 1786 23 assay assay NN cord-023095-4dannjjm 1786 24 ( ( -LRB- cord-023095-4dannjjm 1786 25 IPMA IPMA NNP cord-023095-4dannjjm 1786 26 ) ) -RRB- cord-023095-4dannjjm 1786 27 , , , cord-023095-4dannjjm 1786 28 or or CC cord-023095-4dannjjm 1786 29 both both DT cord-023095-4dannjjm 1786 30 . . . cord-023095-4dannjjm 1787 1 An an DT cord-023095-4dannjjm 1787 2 IPMA IPMA NNP cord-023095-4dannjjm 1787 3 titer titer NN cord-023095-4dannjjm 1787 4 greater great JJR cord-023095-4dannjjm 1787 5 than than IN cord-023095-4dannjjm 1787 6 or or CC cord-023095-4dannjjm 1787 7 equal equal JJ cord-023095-4dannjjm 1787 8 to to IN cord-023095-4dannjjm 1787 9 60 60 CD cord-023095-4dannjjm 1787 10 was be VBD cord-023095-4dannjjm 1787 11 considered consider VBN cord-023095-4dannjjm 1787 12 positive positive JJ cord-023095-4dannjjm 1787 13 for for IN cord-023095-4dannjjm 1787 14 disease disease NN cord-023095-4dannjjm 1787 15 . . . cord-023095-4dannjjm 1788 1 116 116 CD cord-023095-4dannjjm 1788 2 horses horse NNS cord-023095-4dannjjm 1788 3 met meet VBD cord-023095-4dannjjm 1788 4 the the DT cord-023095-4dannjjm 1788 5 initial initial JJ cord-023095-4dannjjm 1788 6 criteria criterion NNS cord-023095-4dannjjm 1788 7 . . . cord-023095-4dannjjm 1789 1 36 36 CD cord-023095-4dannjjm 1789 2 of of IN cord-023095-4dannjjm 1789 3 the the DT cord-023095-4dannjjm 1789 4 116 116 CD cord-023095-4dannjjm 1789 5 horses horse NNS cord-023095-4dannjjm 1789 6 sold sell VBN cord-023095-4dannjjm 1789 7 at at IN cord-023095-4dannjjm 1789 8 public public JJ cord-023095-4dannjjm 1789 9 auction auction NN cord-023095-4dannjjm 1789 10 as as IN cord-023095-4dannjjm 1789 11 yearlings yearling NNS cord-023095-4dannjjm 1789 12 . . . cord-023095-4dannjjm 1790 1 The the DT cord-023095-4dannjjm 1790 2 sale sale NN cord-023095-4dannjjm 1790 3 price price NN cord-023095-4dannjjm 1790 4 of of IN cord-023095-4dannjjm 1790 5 these these DT cord-023095-4dannjjm 1790 6 horses horse NNS cord-023095-4dannjjm 1790 7 was be VBD cord-023095-4dannjjm 1790 8 compared compare VBN cord-023095-4dannjjm 1790 9 to to IN cord-023095-4dannjjm 1790 10 the the DT cord-023095-4dannjjm 1790 11 average average JJ cord-023095-4dannjjm 1790 12 sale sale NN cord-023095-4dannjjm 1790 13 price price NN cord-023095-4dannjjm 1790 14 of of IN cord-023095-4dannjjm 1790 15 all all DT cord-023095-4dannjjm 1790 16 yearlings yearling NNS cord-023095-4dannjjm 1790 17 by by IN cord-023095-4dannjjm 1790 18 the the DT cord-023095-4dannjjm 1790 19 same same JJ cord-023095-4dannjjm 1790 20 sire sire NN cord-023095-4dannjjm 1790 21 as as IN cord-023095-4dannjjm 1790 22 the the DT cord-023095-4dannjjm 1790 23 affected affected JJ cord-023095-4dannjjm 1790 24 horse horse NN cord-023095-4dannjjm 1790 25 ( ( -LRB- cord-023095-4dannjjm 1790 26 control control NNP cord-023095-4dannjjm 1790 27 group group NN cord-023095-4dannjjm 1790 28 ) ) -RRB- cord-023095-4dannjjm 1790 29 . . . cord-023095-4dannjjm 1791 1 30 30 CD cord-023095-4dannjjm 1791 2 of of IN cord-023095-4dannjjm 1791 3 the the DT cord-023095-4dannjjm 1791 4 116 116 CD cord-023095-4dannjjm 1791 5 horses horse NNS cord-023095-4dannjjm 1791 6 raced race VBD cord-023095-4dannjjm 1791 7 in in IN cord-023095-4dannjjm 1791 8 the the DT cord-023095-4dannjjm 1791 9 United United NNP cord-023095-4dannjjm 1791 10 States States NNP cord-023095-4dannjjm 1791 11 . . . cord-023095-4dannjjm 1792 1 Their -PRON- PRP$ cord-023095-4dannjjm 1792 2 monetary monetary JJ cord-023095-4dannjjm 1792 3 earnings earning NNS cord-023095-4dannjjm 1792 4 from from IN cord-023095-4dannjjm 1792 5 racing racing NN cord-023095-4dannjjm 1792 6 were be VBD cord-023095-4dannjjm 1792 7 compared compare VBN cord-023095-4dannjjm 1792 8 to to IN cord-023095-4dannjjm 1792 9 the the DT cord-023095-4dannjjm 1792 10 average average JJ cord-023095-4dannjjm 1792 11 monetary monetary JJ cord-023095-4dannjjm 1792 12 earnings earning NNS cord-023095-4dannjjm 1792 13 of of IN cord-023095-4dannjjm 1792 14 all all DT cord-023095-4dannjjm 1792 15 progeny progeny NN cord-023095-4dannjjm 1792 16 by by IN cord-023095-4dannjjm 1792 17 the the DT cord-023095-4dannjjm 1792 18 same same JJ cord-023095-4dannjjm 1792 19 sire sire NN cord-023095-4dannjjm 1792 20 as as IN cord-023095-4dannjjm 1792 21 the the DT cord-023095-4dannjjm 1792 22 affected affected JJ cord-023095-4dannjjm 1792 23 horse horse NN cord-023095-4dannjjm 1792 24 ( ( -LRB- cord-023095-4dannjjm 1792 25 control control NNP cord-023095-4dannjjm 1792 26 group group NN cord-023095-4dannjjm 1792 27 ) ) -RRB- cord-023095-4dannjjm 1792 28 . . . cord-023095-4dannjjm 1793 1 Earnings earning NNS cord-023095-4dannjjm 1793 2 of of IN cord-023095-4dannjjm 1793 3 horses horse NNS cord-023095-4dannjjm 1793 4 that that WDT cord-023095-4dannjjm 1793 5 were be VBD cord-023095-4dannjjm 1793 6 between between IN cord-023095-4dannjjm 1793 7 3 3 CD cord-023095-4dannjjm 1793 8 and and CC cord-023095-4dannjjm 1793 9 7 7 CD cord-023095-4dannjjm 1793 10 years year NNS cord-023095-4dannjjm 1793 11 of of IN cord-023095-4dannjjm 1793 12 age age NN cord-023095-4dannjjm 1793 13 ( ( -LRB- cord-023095-4dannjjm 1793 14 23/30 23/30 CD cord-023095-4dannjjm 1793 15 horses horse NNS cord-023095-4dannjjm 1793 16 ) ) -RRB- cord-023095-4dannjjm 1793 17 at at IN cord-023095-4dannjjm 1793 18 the the DT cord-023095-4dannjjm 1793 19 conclusion conclusion NN cord-023095-4dannjjm 1793 20 of of IN cord-023095-4dannjjm 1793 21 the the DT cord-023095-4dannjjm 1793 22 study study NN cord-023095-4dannjjm 1793 23 were be VBD cord-023095-4dannjjm 1793 24 compared compare VBN cord-023095-4dannjjm 1793 25 to to IN cord-023095-4dannjjm 1793 26 the the DT cord-023095-4dannjjm 1793 27 lifetime lifetime NN cord-023095-4dannjjm 1793 28 average average JJ cord-023095-4dannjjm 1793 29 earnings earning NNS cord-023095-4dannjjm 1793 30 of of IN cord-023095-4dannjjm 1793 31 the the DT cord-023095-4dannjjm 1793 32 stallion stallion NN cord-023095-4dannjjm 1793 33 's 's POS cord-023095-4dannjjm 1793 34 progeny progeny NN cord-023095-4dannjjm 1793 35 . . . cord-023095-4dannjjm 1794 1 Earnings earning NNS cord-023095-4dannjjm 1794 2 from from IN cord-023095-4dannjjm 1794 3 horses horse NNS cord-023095-4dannjjm 1794 4 that that WDT cord-023095-4dannjjm 1794 5 were be VBD cord-023095-4dannjjm 1794 6 two two CD cord-023095-4dannjjm 1794 7 years year NNS cord-023095-4dannjjm 1794 8 of of IN cord-023095-4dannjjm 1794 9 age age NN cord-023095-4dannjjm 1794 10 ( ( -LRB- cord-023095-4dannjjm 1794 11 7/30 7/30 CD cord-023095-4dannjjm 1794 12 ) ) -RRB- cord-023095-4dannjjm 1794 13 at at IN cord-023095-4dannjjm 1794 14 the the DT cord-023095-4dannjjm 1794 15 end end NN cord-023095-4dannjjm 1794 16 of of IN cord-023095-4dannjjm 1794 17 the the DT cord-023095-4dannjjm 1794 18 study study NN cord-023095-4dannjjm 1794 19 were be VBD cord-023095-4dannjjm 1794 20 compared compare VBN cord-023095-4dannjjm 1794 21 to to IN cord-023095-4dannjjm 1794 22 the the DT cord-023095-4dannjjm 1794 23 two two CD cord-023095-4dannjjm 1794 24 year year NN cord-023095-4dannjjm 1794 25 old old JJ cord-023095-4dannjjm 1794 26 average average JJ cord-023095-4dannjjm 1794 27 earnings earning NNS cord-023095-4dannjjm 1794 28 of of IN cord-023095-4dannjjm 1794 29 the the DT cord-023095-4dannjjm 1794 30 stallion stallion NN cord-023095-4dannjjm 1794 31 's 's POS cord-023095-4dannjjm 1794 32 progeny progeny NN cord-023095-4dannjjm 1794 33 . . . cord-023095-4dannjjm 1795 1 Monetary monetary JJ cord-023095-4dannjjm 1795 2 earnings earning NNS cord-023095-4dannjjm 1795 3 from from IN cord-023095-4dannjjm 1795 4 all all DT cord-023095-4dannjjm 1795 5 races race NNS cord-023095-4dannjjm 1795 6 prior prior RB cord-023095-4dannjjm 1795 7 to to IN cord-023095-4dannjjm 1795 8 December December NNP cord-023095-4dannjjm 1795 9 31 31 CD cord-023095-4dannjjm 1795 10 , , , cord-023095-4dannjjm 1795 11 2008 2008 CD cord-023095-4dannjjm 1795 12 were be VBD cord-023095-4dannjjm 1795 13 included include VBN cord-023095-4dannjjm 1795 14 in in IN cord-023095-4dannjjm 1795 15 the the DT cord-023095-4dannjjm 1795 16 study study NN cord-023095-4dannjjm 1795 17 . . . cord-023095-4dannjjm 1796 1 12 12 CD cord-023095-4dannjjm 1796 2 horses horse NNS cord-023095-4dannjjm 1796 3 both both DT cord-023095-4dannjjm 1796 4 sold sell VBD cord-023095-4dannjjm 1796 5 at at IN cord-023095-4dannjjm 1796 6 public public JJ cord-023095-4dannjjm 1796 7 auction auction NN cord-023095-4dannjjm 1796 8 and and CC cord-023095-4dannjjm 1796 9 raced race VBD cord-023095-4dannjjm 1796 10 . . . cord-023095-4dannjjm 1797 1 As as RB cord-023095-4dannjjm 1797 2 well well RB cord-023095-4dannjjm 1797 3 as as IN cord-023095-4dannjjm 1797 4 being be VBG cord-023095-4dannjjm 1797 5 included include VBN cord-023095-4dannjjm 1797 6 in in IN cord-023095-4dannjjm 1797 7 the the DT cord-023095-4dannjjm 1797 8 total total JJ cord-023095-4dannjjm 1797 9 number number NN cord-023095-4dannjjm 1797 10 of of IN cord-023095-4dannjjm 1797 11 horses horse NNS cord-023095-4dannjjm 1797 12 that that WDT cord-023095-4dannjjm 1797 13 sold sell VBD cord-023095-4dannjjm 1797 14 and and CC cord-023095-4dannjjm 1797 15 raced race VBD cord-023095-4dannjjm 1797 16 , , , cord-023095-4dannjjm 1797 17 their -PRON- PRP$ cord-023095-4dannjjm 1797 18 sale sale NN cord-023095-4dannjjm 1797 19 records record NNS cord-023095-4dannjjm 1797 20 and and CC cord-023095-4dannjjm 1797 21 monetary monetary JJ cord-023095-4dannjjm 1797 22 earnings earning NNS cord-023095-4dannjjm 1797 23 were be VBD cord-023095-4dannjjm 1797 24 compared compare VBN cord-023095-4dannjjm 1797 25 to to IN cord-023095-4dannjjm 1797 26 the the DT cord-023095-4dannjjm 1797 27 averages average NNS cord-023095-4dannjjm 1797 28 from from IN cord-023095-4dannjjm 1797 29 their -PRON- PRP$ cord-023095-4dannjjm 1797 30 respective respective JJ cord-023095-4dannjjm 1797 31 sire sire NN cord-023095-4dannjjm 1797 32 as as IN cord-023095-4dannjjm 1797 33 a a DT cord-023095-4dannjjm 1797 34 separate separate JJ cord-023095-4dannjjm 1797 35 group group NN cord-023095-4dannjjm 1797 36 . . . cord-023095-4dannjjm 1798 1 This this DT cord-023095-4dannjjm 1798 2 retrospective retrospective JJ cord-023095-4dannjjm 1798 3 study study NN cord-023095-4dannjjm 1798 4 indicated indicate VBD cord-023095-4dannjjm 1798 5 that that IN cord-023095-4dannjjm 1798 6 yearling yearling NN cord-023095-4dannjjm 1798 7 horses horse NNS cord-023095-4dannjjm 1798 8 previously previously RB cord-023095-4dannjjm 1798 9 infected infect VBN cord-023095-4dannjjm 1798 10 with with IN cord-023095-4dannjjm 1798 11 LI LI NNP cord-023095-4dannjjm 1798 12 do do VBP cord-023095-4dannjjm 1798 13 not not RB cord-023095-4dannjjm 1798 14 sell sell VB cord-023095-4dannjjm 1798 15 for for IN cord-023095-4dannjjm 1798 16 as as RB cord-023095-4dannjjm 1798 17 much much JJ cord-023095-4dannjjm 1798 18 at at IN cord-023095-4dannjjm 1798 19 public public JJ cord-023095-4dannjjm 1798 20 auction auction NN cord-023095-4dannjjm 1798 21 as as IN cord-023095-4dannjjm 1798 22 their -PRON- PRP$ cord-023095-4dannjjm 1798 23 herdmates herdmate NNS cord-023095-4dannjjm 1798 24 , , , cord-023095-4dannjjm 1798 25 but but CC cord-023095-4dannjjm 1798 26 their -PRON- PRP$ cord-023095-4dannjjm 1798 27 monetary monetary JJ cord-023095-4dannjjm 1798 28 earnings earning NNS cord-023095-4dannjjm 1798 29 from from IN cord-023095-4dannjjm 1798 30 racing racing NN cord-023095-4dannjjm 1798 31 are be VBP cord-023095-4dannjjm 1798 32 not not RB cord-023095-4dannjjm 1798 33 significantly significantly RB cord-023095-4dannjjm 1798 34 different different JJ cord-023095-4dannjjm 1798 35 from from IN cord-023095-4dannjjm 1798 36 other other JJ cord-023095-4dannjjm 1798 37 horses horse NNS cord-023095-4dannjjm 1798 38 . . . cord-023095-4dannjjm 1799 1 These these DT cord-023095-4dannjjm 1799 2 results result NNS cord-023095-4dannjjm 1799 3 should should MD cord-023095-4dannjjm 1799 4 assist assist VB cord-023095-4dannjjm 1799 5 practitioners practitioner NNS cord-023095-4dannjjm 1799 6 in in IN cord-023095-4dannjjm 1799 7 guiding guide VBG cord-023095-4dannjjm 1799 8 owners owner NNS cord-023095-4dannjjm 1799 9 in in IN cord-023095-4dannjjm 1799 10 determing determe VBG cord-023095-4dannjjm 1799 11 if if IN cord-023095-4dannjjm 1799 12 treatment treatment NN cord-023095-4dannjjm 1799 13 of of IN cord-023095-4dannjjm 1799 14 horses horse NNS cord-023095-4dannjjm 1799 15 with with IN cord-023095-4dannjjm 1799 16 EPE EPE NNP cord-023095-4dannjjm 1799 17 is be VBZ cord-023095-4dannjjm 1799 18 appropriate appropriate JJ cord-023095-4dannjjm 1799 19 and and CC cord-023095-4dannjjm 1799 20 it -PRON- PRP cord-023095-4dannjjm 1799 21 may may MD cord-023095-4dannjjm 1799 22 aid aid VB cord-023095-4dannjjm 1799 23 in in IN cord-023095-4dannjjm 1799 24 reassuring reassuring JJ cord-023095-4dannjjm 1799 25 owners owner NNS cord-023095-4dannjjm 1799 26 that that IN cord-023095-4dannjjm 1799 27 despite despite IN cord-023095-4dannjjm 1799 28 the the DT cord-023095-4dannjjm 1799 29 poor poor JJ cord-023095-4dannjjm 1799 30 condition condition NN cord-023095-4dannjjm 1799 31 of of IN cord-023095-4dannjjm 1799 32 the the DT cord-023095-4dannjjm 1799 33 horse horse NN cord-023095-4dannjjm 1799 34 during during IN cord-023095-4dannjjm 1799 35 and and CC cord-023095-4dannjjm 1799 36 shortly shortly RB cord-023095-4dannjjm 1799 37 after after IN cord-023095-4dannjjm 1799 38 the the DT cord-023095-4dannjjm 1799 39 course course NN cord-023095-4dannjjm 1799 40 of of IN cord-023095-4dannjjm 1799 41 disease disease NN cord-023095-4dannjjm 1799 42 , , , cord-023095-4dannjjm 1799 43 horse horse NN cord-023095-4dannjjm 1799 44 may may MD cord-023095-4dannjjm 1799 45 still still RB cord-023095-4dannjjm 1799 46 have have VB cord-023095-4dannjjm 1799 47 future future JJ cord-023095-4dannjjm 1799 48 athletic athletic JJ cord-023095-4dannjjm 1799 49 potential potential NN cord-023095-4dannjjm 1799 50 . . . cord-023095-4dannjjm 1800 1 This this DT cord-023095-4dannjjm 1800 2 abstract abstract NN cord-023095-4dannjjm 1800 3 was be VBD cord-023095-4dannjjm 1800 4 presented present VBN cord-023095-4dannjjm 1800 5 at at IN cord-023095-4dannjjm 1800 6 the the DT cord-023095-4dannjjm 1800 7 AAEP AAEP NNP cord-023095-4dannjjm 1800 8 in in IN cord-023095-4dannjjm 1800 9 December December NNP cord-023095-4dannjjm 1800 10 2009 2009 CD cord-023095-4dannjjm 1800 11 . . . cord-023095-4dannjjm 1801 1 Bronchopneumonia bronchopneumonia NN cord-023095-4dannjjm 1801 2 caused cause VBN cord-023095-4dannjjm 1801 3 by by IN cord-023095-4dannjjm 1801 4 Streptococccus streptococccus JJ cord-023095-4dannjjm 1801 5 equi equi NN cord-023095-4dannjjm 1801 6 subsp subsp NN cord-023095-4dannjjm 1801 7 . . . cord-023095-4dannjjm 1802 1 zooepidemicus zooepidemicus NNP cord-023095-4dannjjm 1802 2 ( ( -LRB- cord-023095-4dannjjm 1802 3 S. S. NNP cord-023095-4dannjjm 1802 4 zooepidemicus zooepidemicus NNP cord-023095-4dannjjm 1802 5 ) ) -RRB- cord-023095-4dannjjm 1802 6 is be VBZ cord-023095-4dannjjm 1802 7 one one CD cord-023095-4dannjjm 1802 8 of of IN cord-023095-4dannjjm 1802 9 the the DT cord-023095-4dannjjm 1802 10 most most RBS cord-023095-4dannjjm 1802 11 important important JJ cord-023095-4dannjjm 1802 12 causes cause NNS cord-023095-4dannjjm 1802 13 of of IN cord-023095-4dannjjm 1802 14 morbidity morbidity NN cord-023095-4dannjjm 1802 15 in in IN cord-023095-4dannjjm 1802 16 weanling weanle VBG cord-023095-4dannjjm 1802 17 foals foal NNS cord-023095-4dannjjm 1802 18 . . . cord-023095-4dannjjm 1803 1 Ceftiofur ceftiofur JJ cord-023095-4dannjjm 1803 2 crystalline crystalline NN cord-023095-4dannjjm 1803 3 free free JJ cord-023095-4dannjjm 1803 4 acid acid NN cord-023095-4dannjjm 1803 5 ( ( -LRB- cord-023095-4dannjjm 1803 6 CCFA CCFA NNP cord-023095-4dannjjm 1803 7 ) ) -RRB- cord-023095-4dannjjm 1803 8 is be VBZ cord-023095-4dannjjm 1803 9 a a DT cord-023095-4dannjjm 1803 10 long long JJ cord-023095-4dannjjm 1803 11 acting act VBG cord-023095-4dannjjm 1803 12 third third JJ cord-023095-4dannjjm 1803 13 - - HYPH cord-023095-4dannjjm 1803 14 generation generation NN cord-023095-4dannjjm 1803 15 cephalosporin cephalosporin NN cord-023095-4dannjjm 1803 16 antimicrobial antimicrobial NNP cord-023095-4dannjjm 1803 17 recently recently RB cord-023095-4dannjjm 1803 18 approved approve VBN cord-023095-4dannjjm 1803 19 for for IN cord-023095-4dannjjm 1803 20 the the DT cord-023095-4dannjjm 1803 21 treatment treatment NN cord-023095-4dannjjm 1803 22 of of IN cord-023095-4dannjjm 1803 23 bronchopneumonia bronchopneumonia NN cord-023095-4dannjjm 1803 24 associated associate VBN cord-023095-4dannjjm 1803 25 with with IN cord-023095-4dannjjm 1803 26 S. S. NNP cord-023095-4dannjjm 1803 27 zooepidemicus zooepidemicus NN cord-023095-4dannjjm 1803 28 in in IN cord-023095-4dannjjm 1803 29 adult adult NN cord-023095-4dannjjm 1803 30 horses horse NNS cord-023095-4dannjjm 1803 31 . . . cord-023095-4dannjjm 1804 1 The the DT cord-023095-4dannjjm 1804 2 objective objective NN cord-023095-4dannjjm 1804 3 of of IN cord-023095-4dannjjm 1804 4 the the DT cord-023095-4dannjjm 1804 5 present present JJ cord-023095-4dannjjm 1804 6 study study NN cord-023095-4dannjjm 1804 7 was be VBD cord-023095-4dannjjm 1804 8 to to TO cord-023095-4dannjjm 1804 9 determine determine VB cord-023095-4dannjjm 1804 10 the the DT cord-023095-4dannjjm 1804 11 disposition disposition NN cord-023095-4dannjjm 1804 12 of of IN cord-023095-4dannjjm 1804 13 CCFA CCFA NNP cord-023095-4dannjjm 1804 14 in in IN cord-023095-4dannjjm 1804 15 plasma plasma NN cord-023095-4dannjjm 1804 16 and and CC cord-023095-4dannjjm 1804 17 pulmonary pulmonary JJ cord-023095-4dannjjm 1804 18 epithelial epithelial JJ cord-023095-4dannjjm 1804 19 lining lining NN cord-023095-4dannjjm 1804 20 fluid fluid NN cord-023095-4dannjjm 1804 21 ( ( -LRB- cord-023095-4dannjjm 1804 22 PELF PELF NNP cord-023095-4dannjjm 1804 23 ) ) -RRB- cord-023095-4dannjjm 1804 24 of of IN cord-023095-4dannjjm 1804 25 weanling weanle VBG cord-023095-4dannjjm 1804 26 foals foal NNS cord-023095-4dannjjm 1804 27 . . . cord-023095-4dannjjm 1805 1 Six six CD cord-023095-4dannjjm 1805 2 healthy healthy JJ cord-023095-4dannjjm 1805 3 4-to 4-to CD cord-023095-4dannjjm 1805 4 5month 5month JJ cord-023095-4dannjjm 1805 5 - - JJ cord-023095-4dannjjm 1805 6 old old JJ cord-023095-4dannjjm 1805 7 weanling weanle VBG cord-023095-4dannjjm 1805 8 foals foal NNS cord-023095-4dannjjm 1805 9 were be VBD cord-023095-4dannjjm 1805 10 administered administer VBN cord-023095-4dannjjm 1805 11 a a DT cord-023095-4dannjjm 1805 12 single single JJ cord-023095-4dannjjm 1805 13 intramuscular intramuscular JJ cord-023095-4dannjjm 1805 14 injection injection NN cord-023095-4dannjjm 1805 15 of of IN cord-023095-4dannjjm 1805 16 CCFA CCFA NNP cord-023095-4dannjjm 1805 17 at at IN cord-023095-4dannjjm 1805 18 a a DT cord-023095-4dannjjm 1805 19 dose dose NN cord-023095-4dannjjm 1805 20 of of IN cord-023095-4dannjjm 1805 21 6.6 6.6 CD cord-023095-4dannjjm 1805 22 mg mg NNP cord-023095-4dannjjm 1805 23 / / SYM cord-023095-4dannjjm 1805 24 kg kg NNS cord-023095-4dannjjm 1805 25 of of IN cord-023095-4dannjjm 1805 26 body body NN cord-023095-4dannjjm 1805 27 weight weight NN cord-023095-4dannjjm 1805 28 . . . cord-023095-4dannjjm 1806 1 Concentrations concentration NNS cord-023095-4dannjjm 1806 2 of of IN cord-023095-4dannjjm 1806 3 desfuroylceftiofur desfuroylceftiofur JJ cord-023095-4dannjjm 1806 4 acetamide acetamide NNP cord-023095-4dannjjm 1806 5 ( ( -LRB- cord-023095-4dannjjm 1806 6 DCA DCA NNP cord-023095-4dannjjm 1806 7 ) ) -RRB- cord-023095-4dannjjm 1806 8 and and CC cord-023095-4dannjjm 1806 9 related relate VBN cord-023095-4dannjjm 1806 10 metabolites metabolite NNS cord-023095-4dannjjm 1806 11 were be VBD cord-023095-4dannjjm 1806 12 measured measure VBN cord-023095-4dannjjm 1806 13 by by IN cord-023095-4dannjjm 1806 14 use use NN cord-023095-4dannjjm 1806 15 of of IN cord-023095-4dannjjm 1806 16 ultra ultra JJ cord-023095-4dannjjm 1806 17 - - JJ cord-023095-4dannjjm 1806 18 high high JJ cord-023095-4dannjjm 1806 19 performance performance NN cord-023095-4dannjjm 1806 20 liquid liquid NN cord-023095-4dannjjm 1806 21 chromatography chromatography NN cord-023095-4dannjjm 1806 22 and and CC cord-023095-4dannjjm 1806 23 tandem tandem JJ cord-023095-4dannjjm 1806 24 mass mass NN cord-023095-4dannjjm 1806 25 spectrometry spectrometry NN cord-023095-4dannjjm 1806 26 . . . cord-023095-4dannjjm 1807 1 Following follow VBG cord-023095-4dannjjm 1807 2 IM IM NNP cord-023095-4dannjjm 1807 3 administration administration NN cord-023095-4dannjjm 1807 4 , , , cord-023095-4dannjjm 1807 5 median median JJ cord-023095-4dannjjm 1807 6 time time NN cord-023095-4dannjjm 1807 7 to to TO cord-023095-4dannjjm 1807 8 maximum maximum VB cord-023095-4dannjjm 1807 9 plasma plasma NN cord-023095-4dannjjm 1807 10 and and CC cord-023095-4dannjjm 1807 11 PELF PELF NNP cord-023095-4dannjjm 1807 12 concentrations concentration NNS cord-023095-4dannjjm 1807 13 was be VBD cord-023095-4dannjjm 1807 14 24 24 CD cord-023095-4dannjjm 1807 15 h h NN cord-023095-4dannjjm 1807 16 ( ( -LRB- cord-023095-4dannjjm 1807 17 12 12 CD cord-023095-4dannjjm 1807 18 - - SYM cord-023095-4dannjjm 1807 19 48 48 CD cord-023095-4dannjjm 1807 20 h h NN cord-023095-4dannjjm 1807 21 ) ) -RRB- cord-023095-4dannjjm 1807 22 . . . cord-023095-4dannjjm 1808 1 Mean mean JJ cord-023095-4dannjjm 1808 2 ( ( -LRB- cord-023095-4dannjjm 1808 3 AE AE NNP cord-023095-4dannjjm 1808 4 SD SD NNP cord-023095-4dannjjm 1808 5 ) ) -RRB- cord-023095-4dannjjm 1808 6 peak peak NN cord-023095-4dannjjm 1808 7 DCA DCA NNP cord-023095-4dannjjm 1808 8 concentration concentration NN cord-023095-4dannjjm 1808 9 in in IN cord-023095-4dannjjm 1808 10 plasma plasma NN cord-023095-4dannjjm 1808 11 ( ( -LRB- cord-023095-4dannjjm 1808 12 1.44 1.44 CD cord-023095-4dannjjm 1808 13 AE AE NNP cord-023095-4dannjjm 1808 14 0.46 0.46 CD cord-023095-4dannjjm 1808 15 mg mg NNP cord-023095-4dannjjm 1808 16 / / SYM cord-023095-4dannjjm 1808 17 mL mL NNP cord-023095-4dannjjm 1808 18 ) ) -RRB- cord-023095-4dannjjm 1808 19 was be VBD cord-023095-4dannjjm 1808 20 significantly significantly RB cord-023095-4dannjjm 1808 21 higher high JJR cord-023095-4dannjjm 1808 22 than than IN cord-023095-4dannjjm 1808 23 that that DT cord-023095-4dannjjm 1808 24 in in IN cord-023095-4dannjjm 1808 25 PELF PELF NNP cord-023095-4dannjjm 1808 26 ( ( -LRB- cord-023095-4dannjjm 1808 27 0.46 0.46 CD cord-023095-4dannjjm 1808 28 AE AE NNP cord-023095-4dannjjm 1808 29 0.03 0.03 CD cord-023095-4dannjjm 1808 30 mg mg NNP cord-023095-4dannjjm 1808 31 / / SYM cord-023095-4dannjjm 1808 32 mL mL NNP cord-023095-4dannjjm 1808 33 ) ) -RRB- cord-023095-4dannjjm 1808 34 . . . cord-023095-4dannjjm 1809 1 Terminal terminal JJ cord-023095-4dannjjm 1809 2 half half JJ cord-023095-4dannjjm 1809 3 - - HYPH cord-023095-4dannjjm 1809 4 life life NN cord-023095-4dannjjm 1809 5 of of IN cord-023095-4dannjjm 1809 6 DCA DCA NNP cord-023095-4dannjjm 1809 7 in in IN cord-023095-4dannjjm 1809 8 plasma plasma NN cord-023095-4dannjjm 1809 9 ( ( -LRB- cord-023095-4dannjjm 1809 10 74.8 74.8 CD cord-023095-4dannjjm 1809 11 AE AE NNP cord-023095-4dannjjm 1809 12 20.9 20.9 CD cord-023095-4dannjjm 1809 13 h h NNP cord-023095-4dannjjm 1809 14 ) ) -RRB- cord-023095-4dannjjm 1809 15 was be VBD cord-023095-4dannjjm 1809 16 not not RB cord-023095-4dannjjm 1809 17 significantly significantly RB cord-023095-4dannjjm 1809 18 different different JJ cord-023095-4dannjjm 1809 19 from from IN cord-023095-4dannjjm 1809 20 that that DT cord-023095-4dannjjm 1809 21 of of IN cord-023095-4dannjjm 1809 22 PELF PELF NNP cord-023095-4dannjjm 1809 23 ( ( -LRB- cord-023095-4dannjjm 1809 24 58.5 58.5 CD cord-023095-4dannjjm 1809 25 AE AE NNP cord-023095-4dannjjm 1809 26 11.4 11.4 CD cord-023095-4dannjjm 1809 27 h h NNP cord-023095-4dannjjm 1809 28 ) ) -RRB- cord-023095-4dannjjm 1809 29 . . . cord-023095-4dannjjm 1810 1 Time time NN cord-023095-4dannjjm 1810 2 above above IN cord-023095-4dannjjm 1810 3 the the DT cord-023095-4dannjjm 1810 4 therapeutic therapeutic JJ cord-023095-4dannjjm 1810 5 target target NN cord-023095-4dannjjm 1810 6 of of IN cord-023095-4dannjjm 1810 7 0.2 0.2 CD cord-023095-4dannjjm 1810 8 mg mg NN cord-023095-4dannjjm 1810 9 / / SYM cord-023095-4dannjjm 1810 10 mL mL NNP cord-023095-4dannjjm 1810 11 was be VBD cord-023095-4dannjjm 1810 12 significantly significantly RB cord-023095-4dannjjm 1810 13 longer long JJR cord-023095-4dannjjm 1810 14 in in IN cord-023095-4dannjjm 1810 15 plasma plasma NN cord-023095-4dannjjm 1810 16 ( ( -LRB- cord-023095-4dannjjm 1810 17 185 185 CD cord-023095-4dannjjm 1810 18 AE AE NNP cord-023095-4dannjjm 1810 19 20 20 CD cord-023095-4dannjjm 1810 20 h h NN cord-023095-4dannjjm 1810 21 ) ) -RRB- cord-023095-4dannjjm 1810 22 than than IN cord-023095-4dannjjm 1810 23 in in IN cord-023095-4dannjjm 1810 24 PELF PELF NNP cord-023095-4dannjjm 1810 25 ( ( -LRB- cord-023095-4dannjjm 1810 26 107 107 CD cord-023095-4dannjjm 1810 27 AE AE NNP cord-023095-4dannjjm 1810 28 31 31 CD cord-023095-4dannjjm 1810 29 h h NN cord-023095-4dannjjm 1810 30 ) ) -RRB- cord-023095-4dannjjm 1810 31 . . . cord-023095-4dannjjm 1811 1 Based base VBN cord-023095-4dannjjm 1811 2 on on IN cord-023095-4dannjjm 1811 3 the the DT cord-023095-4dannjjm 1811 4 results result NNS cord-023095-4dannjjm 1811 5 of of IN cord-023095-4dannjjm 1811 6 the the DT cord-023095-4dannjjm 1811 7 present present JJ cord-023095-4dannjjm 1811 8 study study NN cord-023095-4dannjjm 1811 9 , , , cord-023095-4dannjjm 1811 10 intramuscular intramuscular JJ cord-023095-4dannjjm 1811 11 administration administration NN cord-023095-4dannjjm 1811 12 of of IN cord-023095-4dannjjm 1811 13 CCFA CCFA NNP cord-023095-4dannjjm 1811 14 at at IN cord-023095-4dannjjm 1811 15 a a DT cord-023095-4dannjjm 1811 16 dose dose NN cord-023095-4dannjjm 1811 17 of of IN cord-023095-4dannjjm 1811 18 6.6 6.6 CD cord-023095-4dannjjm 1811 19 mg mg NNP cord-023095-4dannjjm 1811 20 / / SYM cord-023095-4dannjjm 1811 21 kg kg NN cord-023095-4dannjjm 1811 22 would would MD cord-023095-4dannjjm 1811 23 be be VB cord-023095-4dannjjm 1811 24 appropriate appropriate JJ cord-023095-4dannjjm 1811 25 for for IN cord-023095-4dannjjm 1811 26 the the DT cord-023095-4dannjjm 1811 27 treatment treatment NN cord-023095-4dannjjm 1811 28 of of IN cord-023095-4dannjjm 1811 29 bronchopneumonia bronchopneumonia NN cord-023095-4dannjjm 1811 30 caused cause VBN cord-023095-4dannjjm 1811 31 by by IN cord-023095-4dannjjm 1811 32 S. S. NNP cord-023095-4dannjjm 1811 33 zooepidemicus zooepidemicus NNP cord-023095-4dannjjm 1811 34 and and CC cord-023095-4dannjjm 1811 35 other other JJ cord-023095-4dannjjm 1811 36 susceptible susceptible JJ cord-023095-4dannjjm 1811 37 pathogens pathogen NNS cord-023095-4dannjjm 1811 38 in in IN cord-023095-4dannjjm 1811 39 weanling weanle VBG cord-023095-4dannjjm 1811 40 foals foal NNS cord-023095-4dannjjm 1811 41 . . . cord-023095-4dannjjm 1812 1 FGF-23 FGF-23 NNP cord-023095-4dannjjm 1812 2 is be VBZ cord-023095-4dannjjm 1812 3 secreted secrete VBN cord-023095-4dannjjm 1812 4 by by IN cord-023095-4dannjjm 1812 5 osteocytes osteocyte NNS cord-023095-4dannjjm 1812 6 and and CC cord-023095-4dannjjm 1812 7 osteoblasts osteoblast NNS cord-023095-4dannjjm 1812 8 in in IN cord-023095-4dannjjm 1812 9 response response NN cord-023095-4dannjjm 1812 10 to to IN cord-023095-4dannjjm 1812 11 hyperphosphatemia hyperphosphatemia NN cord-023095-4dannjjm 1812 12 . . . cord-023095-4dannjjm 1813 1 FGF-23 FGF-23 NNP cord-023095-4dannjjm 1813 2 enhances enhance VBZ cord-023095-4dannjjm 1813 3 phosphaturia phosphaturia NNS cord-023095-4dannjjm 1813 4 and and CC cord-023095-4dannjjm 1813 5 is be VBZ cord-023095-4dannjjm 1813 6 postulated postulate VBN cord-023095-4dannjjm 1813 7 to to TO cord-023095-4dannjjm 1813 8 have have VB cord-023095-4dannjjm 1813 9 a a DT cord-023095-4dannjjm 1813 10 central central JJ cord-023095-4dannjjm 1813 11 role role NN cord-023095-4dannjjm 1813 12 in in IN cord-023095-4dannjjm 1813 13 the the DT cord-023095-4dannjjm 1813 14 development development NN cord-023095-4dannjjm 1813 15 of of IN cord-023095-4dannjjm 1813 16 secondary secondary JJ cord-023095-4dannjjm 1813 17 renal renal JJ cord-023095-4dannjjm 1813 18 hyperparathyroidism hyperparathyroidism NN cord-023095-4dannjjm 1813 19 . . . cord-023095-4dannjjm 1814 1 Hyperthyroid Hyperthyroid NNP cord-023095-4dannjjm 1814 2 cats cat NNS cord-023095-4dannjjm 1814 3 have have VBP cord-023095-4dannjjm 1814 4 elevated elevate VBN cord-023095-4dannjjm 1814 5 plasma plasma NN cord-023095-4dannjjm 1814 6 phosphate phosphate NN cord-023095-4dannjjm 1814 7 and and CC cord-023095-4dannjjm 1814 8 parathyroid parathyroid JJ cord-023095-4dannjjm 1814 9 hormone hormone NN cord-023095-4dannjjm 1814 10 concentrations concentration NNS cord-023095-4dannjjm 1814 11 , , , cord-023095-4dannjjm 1814 12 which which WDT cord-023095-4dannjjm 1814 13 may may MD cord-023095-4dannjjm 1814 14 in in IN cord-023095-4dannjjm 1814 15 part part NN cord-023095-4dannjjm 1814 16 be be VB cord-023095-4dannjjm 1814 17 associated associate VBN cord-023095-4dannjjm 1814 18 with with IN cord-023095-4dannjjm 1814 19 underlying underlie VBG cord-023095-4dannjjm 1814 20 chronic chronic JJ cord-023095-4dannjjm 1814 21 kidney kidney NN cord-023095-4dannjjm 1814 22 disease disease NN cord-023095-4dannjjm 1814 23 ( ( -LRB- cord-023095-4dannjjm 1814 24 CKD CKD NNP cord-023095-4dannjjm 1814 25 ) ) -RRB- cord-023095-4dannjjm 1814 26 . . . cord-023095-4dannjjm 1815 1 The the DT cord-023095-4dannjjm 1815 2 aim aim NN cord-023095-4dannjjm 1815 3 of of IN cord-023095-4dannjjm 1815 4 this this DT cord-023095-4dannjjm 1815 5 study study NN cord-023095-4dannjjm 1815 6 was be VBD cord-023095-4dannjjm 1815 7 to to TO cord-023095-4dannjjm 1815 8 determine determine VB cord-023095-4dannjjm 1815 9 if if IN cord-023095-4dannjjm 1815 10 plasma plasma NN cord-023095-4dannjjm 1815 11 FGF-23 FGF-23 NNP cord-023095-4dannjjm 1815 12 concentrations concentration NNS cord-023095-4dannjjm 1815 13 were be VBD cord-023095-4dannjjm 1815 14 associated associate VBN cord-023095-4dannjjm 1815 15 with with IN cord-023095-4dannjjm 1815 16 the the DT cord-023095-4dannjjm 1815 17 presence presence NN cord-023095-4dannjjm 1815 18 of of IN cord-023095-4dannjjm 1815 19 underlying underlie VBG cord-023095-4dannjjm 1815 20 CKD CKD NNP cord-023095-4dannjjm 1815 21 in in IN cord-023095-4dannjjm 1815 22 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 1815 23 cats cat NNS cord-023095-4dannjjm 1815 24 , , , cord-023095-4dannjjm 1815 25 and and CC cord-023095-4dannjjm 1815 26 to to TO cord-023095-4dannjjm 1815 27 investigate investigate VB cord-023095-4dannjjm 1815 28 the the DT cord-023095-4dannjjm 1815 29 changes change NNS cord-023095-4dannjjm 1815 30 in in IN cord-023095-4dannjjm 1815 31 plasma plasma NN cord-023095-4dannjjm 1815 32 FGF-23 FGF-23 NNP cord-023095-4dannjjm 1815 33 concentrations concentration NNS cord-023095-4dannjjm 1815 34 that that WDT cord-023095-4dannjjm 1815 35 occur occur VBP cord-023095-4dannjjm 1815 36 following follow VBG cord-023095-4dannjjm 1815 37 treatment treatment NN cord-023095-4dannjjm 1815 38 of of IN cord-023095-4dannjjm 1815 39 HTH HTH NNP cord-023095-4dannjjm 1815 40 . . . cord-023095-4dannjjm 1816 1 Hyperthyroid Hyperthyroid NNP cord-023095-4dannjjm 1816 2 cats cat NNS cord-023095-4dannjjm 1816 3 were be VBD cord-023095-4dannjjm 1816 4 recruited recruit VBN cord-023095-4dannjjm 1816 5 from from IN cord-023095-4dannjjm 1816 6 two two CD cord-023095-4dannjjm 1816 7 London London NNP cord-023095-4dannjjm 1816 8 - - HYPH cord-023095-4dannjjm 1816 9 based base VBN cord-023095-4dannjjm 1816 10 first first JJ cord-023095-4dannjjm 1816 11 opinion opinion NN cord-023095-4dannjjm 1816 12 practices practice NNS cord-023095-4dannjjm 1816 13 between between IN cord-023095-4dannjjm 1816 14 1999 1999 CD cord-023095-4dannjjm 1816 15 and and CC cord-023095-4dannjjm 1816 16 2009 2009 CD cord-023095-4dannjjm 1816 17 . . . cord-023095-4dannjjm 1817 1 Cats cat NNS cord-023095-4dannjjm 1817 2 that that WDT cord-023095-4dannjjm 1817 3 were be VBD cord-023095-4dannjjm 1817 4 azotemic azotemic JJ cord-023095-4dannjjm 1817 5 at at IN cord-023095-4dannjjm 1817 6 diagnosis diagnosis NN cord-023095-4dannjjm 1817 7 were be VBD cord-023095-4dannjjm 1817 8 excluded exclude VBN cord-023095-4dannjjm 1817 9 . . . cord-023095-4dannjjm 1818 1 HTH HTH NNP cord-023095-4dannjjm 1818 2 was be VBD cord-023095-4dannjjm 1818 3 treated treat VBN cord-023095-4dannjjm 1818 4 with with IN cord-023095-4dannjjm 1818 5 anti anti JJ cord-023095-4dannjjm 1818 6 - - JJ cord-023095-4dannjjm 1818 7 thyroid thyroid JJ cord-023095-4dannjjm 1818 8 medication medication NN cord-023095-4dannjjm 1818 9 alone alone RB cord-023095-4dannjjm 1818 10 or or CC cord-023095-4dannjjm 1818 11 in in IN cord-023095-4dannjjm 1818 12 combination combination NN cord-023095-4dannjjm 1818 13 with with IN cord-023095-4dannjjm 1818 14 thyroidectomy thyroidectomy NN cord-023095-4dannjjm 1818 15 . . . cord-023095-4dannjjm 1819 1 Cats cat NNS cord-023095-4dannjjm 1819 2 were be VBD cord-023095-4dannjjm 1819 3 included include VBN cord-023095-4dannjjm 1819 4 in in IN cord-023095-4dannjjm 1819 5 the the DT cord-023095-4dannjjm 1819 6 study study NN cord-023095-4dannjjm 1819 7 if if IN cord-023095-4dannjjm 1819 8 they -PRON- PRP cord-023095-4dannjjm 1819 9 had have VBD cord-023095-4dannjjm 1819 10 a a DT cord-023095-4dannjjm 1819 11 plasma plasma JJ cord-023095-4dannjjm 1819 12 total total JJ cord-023095-4dannjjm 1819 13 thyroxine thyroxine JJ cord-023095-4dannjjm 1819 14 concentration concentration NN cord-023095-4dannjjm 1819 15 o o NNP cord-023095-4dannjjm 1819 16 40 40 CD cord-023095-4dannjjm 1819 17 nmol nmol NNP cord-023095-4dannjjm 1819 18 / / SYM cord-023095-4dannjjm 1819 19 l l NNP cord-023095-4dannjjm 1819 20 documented document VBD cord-023095-4dannjjm 1819 21 for for IN cord-023095-4dannjjm 1819 22 a a DT cord-023095-4dannjjm 1819 23 six six CD cord-023095-4dannjjm 1819 24 month month NN cord-023095-4dannjjm 1819 25 period period NN cord-023095-4dannjjm 1819 26 following follow VBG cord-023095-4dannjjm 1819 27 commencement commencement NN cord-023095-4dannjjm 1819 28 of of IN cord-023095-4dannjjm 1819 29 treatment treatment NN cord-023095-4dannjjm 1819 30 . . . cord-023095-4dannjjm 1820 1 Cats cat NNS cord-023095-4dannjjm 1820 2 were be VBD cord-023095-4dannjjm 1820 3 classified classify VBN cord-023095-4dannjjm 1820 4 as as IN cord-023095-4dannjjm 1820 5 having have VBG cord-023095-4dannjjm 1820 6 azotemic azotemic JJ cord-023095-4dannjjm 1820 7 CKD CKD NNP cord-023095-4dannjjm 1820 8 if if IN cord-023095-4dannjjm 1820 9 they -PRON- PRP cord-023095-4dannjjm 1820 10 developed develop VBD cord-023095-4dannjjm 1820 11 renal renal JJ cord-023095-4dannjjm 1820 12 azotemia azotemia NN cord-023095-4dannjjm 1820 13 within within IN cord-023095-4dannjjm 1820 14 six six CD cord-023095-4dannjjm 1820 15 months month NNS cord-023095-4dannjjm 1820 16 of of IN cord-023095-4dannjjm 1820 17 establishment establishment NN cord-023095-4dannjjm 1820 18 of of IN cord-023095-4dannjjm 1820 19 euthyroidism euthyroidism NN cord-023095-4dannjjm 1820 20 . . . cord-023095-4dannjjm 1821 1 Otherwise otherwise RB cord-023095-4dannjjm 1821 2 cats cat NNS cord-023095-4dannjjm 1821 3 were be VBD cord-023095-4dannjjm 1821 4 deemed deem VBN cord-023095-4dannjjm 1821 5 to to TO cord-023095-4dannjjm 1821 6 have have VB cord-023095-4dannjjm 1821 7 normal normal JJ cord-023095-4dannjjm 1821 8 renal renal JJ cord-023095-4dannjjm 1821 9 function function NN cord-023095-4dannjjm 1821 10 . . . cord-023095-4dannjjm 1822 1 Stored store VBN cord-023095-4dannjjm 1822 2 EDTA edta NN cord-023095-4dannjjm 1822 3 plasma plasma NN cord-023095-4dannjjm 1822 4 samples sample NNS cord-023095-4dannjjm 1822 5 were be VBD cord-023095-4dannjjm 1822 6 assayed assay VBN cord-023095-4dannjjm 1822 7 for for IN cord-023095-4dannjjm 1822 8 FGF-23 FGF-23 NNPS cord-023095-4dannjjm 1822 9 using use VBG cord-023095-4dannjjm 1822 10 a a DT cord-023095-4dannjjm 1822 11 recently recently RB cord-023095-4dannjjm 1822 12 validated validate VBN cord-023095-4dannjjm 1822 13 ELISA ELISA NNP cord-023095-4dannjjm 1822 14 . . . cord-023095-4dannjjm 1823 1 The the DT cord-023095-4dannjjm 1823 2 Mann Mann NNP cord-023095-4dannjjm 1823 3 - - HYPH cord-023095-4dannjjm 1823 4 Whitney Whitney NNP cord-023095-4dannjjm 1823 5 U U NNP cord-023095-4dannjjm 1823 6 test test NN cord-023095-4dannjjm 1823 7 and and CC cord-023095-4dannjjm 1823 8 the the DT cord-023095-4dannjjm 1823 9 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 1823 10 signed sign VBD cord-023095-4dannjjm 1823 11 rank rank NN cord-023095-4dannjjm 1823 12 test test NN cord-023095-4dannjjm 1823 13 were be VBD cord-023095-4dannjjm 1823 14 used use VBN cord-023095-4dannjjm 1823 15 to to TO cord-023095-4dannjjm 1823 16 compare compare VB cord-023095-4dannjjm 1823 17 between between IN cord-023095-4dannjjm 1823 18 the the DT cord-023095-4dannjjm 1823 19 groups group NNS cord-023095-4dannjjm 1823 20 and and CC cord-023095-4dannjjm 1823 21 assess assess VB cord-023095-4dannjjm 1823 22 the the DT cord-023095-4dannjjm 1823 23 response response NN cord-023095-4dannjjm 1823 24 to to IN cord-023095-4dannjjm 1823 25 treatment treatment NN cord-023095-4dannjjm 1823 26 respectively respectively RB cord-023095-4dannjjm 1823 27 . . . cord-023095-4dannjjm 1824 1 Results result NNS cord-023095-4dannjjm 1824 2 are be VBP cord-023095-4dannjjm 1824 3 reported report VBN cord-023095-4dannjjm 1824 4 as as IN cord-023095-4dannjjm 1824 5 median median JJ cord-023095-4dannjjm 1824 6 [ [ -LRB- cord-023095-4dannjjm 1824 7 25 25 CD cord-023095-4dannjjm 1824 8 th th XX cord-023095-4dannjjm 1824 9 , , , cord-023095-4dannjjm 1824 10 75 75 CD cord-023095-4dannjjm 1824 11 th th XX cord-023095-4dannjjm 1824 12 percentiles percentile NNS cord-023095-4dannjjm 1824 13 ] ] -RRB- cord-023095-4dannjjm 1824 14 . . . cord-023095-4dannjjm 1825 1 Correlations correlation NNS cord-023095-4dannjjm 1825 2 were be VBD cord-023095-4dannjjm 1825 3 made make VBN cord-023095-4dannjjm 1825 4 using use VBG cord-023095-4dannjjm 1825 5 Spearman Spearman NNP cord-023095-4dannjjm 1825 6 's 's POS cord-023095-4dannjjm 1825 7 correlation correlation NN cord-023095-4dannjjm 1825 8 coefficient coefficient NN cord-023095-4dannjjm 1825 9 . . . cord-023095-4dannjjm 1826 1 Thirty thirty CD cord-023095-4dannjjm 1826 2 one one CD cord-023095-4dannjjm 1826 3 cats cat NNS cord-023095-4dannjjm 1826 4 with with IN cord-023095-4dannjjm 1826 5 HTH HTH NNP cord-023095-4dannjjm 1826 6 ( ( -LRB- cord-023095-4dannjjm 1826 7 14 14 CD cord-023095-4dannjjm 1826 8 azotemic azotemic NNS cord-023095-4dannjjm 1826 9 and and CC cord-023095-4dannjjm 1826 10 17 17 CD cord-023095-4dannjjm 1826 11 non non JJ cord-023095-4dannjjm 1826 12 - - JJ cord-023095-4dannjjm 1826 13 azotemic azotemic JJ cord-023095-4dannjjm 1826 14 ) ) -RRB- cord-023095-4dannjjm 1826 15 were be VBD cord-023095-4dannjjm 1826 16 included include VBN cord-023095-4dannjjm 1826 17 in in IN cord-023095-4dannjjm 1826 18 the the DT cord-023095-4dannjjm 1826 19 study study NN cord-023095-4dannjjm 1826 20 . . . cord-023095-4dannjjm 1827 1 Plasma plasma NN cord-023095-4dannjjm 1827 2 phosphate phosphate NN cord-023095-4dannjjm 1827 3 concentrations concentration NNS cord-023095-4dannjjm 1827 4 decreased decrease VBD cord-023095-4dannjjm 1827 5 following follow VBG cord-023095-4dannjjm 1827 6 treatment treatment NN cord-023095-4dannjjm 1827 7 in in IN cord-023095-4dannjjm 1827 8 cats cat NNS cord-023095-4dannjjm 1827 9 that that WDT cord-023095-4dannjjm 1827 10 did do VBD cord-023095-4dannjjm 1827 11 not not RB cord-023095-4dannjjm 1827 12 develop develop VB cord-023095-4dannjjm 1827 13 azotemia azotemia NN cord-023095-4dannjjm 1827 14 ( ( -LRB- cord-023095-4dannjjm 1827 15 4.84 4.84 CD cord-023095-4dannjjm 1827 16 [ [ -LRB- cord-023095-4dannjjm 1827 17 3.91 3.91 CD cord-023095-4dannjjm 1827 18 , , , cord-023095-4dannjjm 1827 19 5.64 5.64 CD cord-023095-4dannjjm 1827 20 ] ] -RRB- cord-023095-4dannjjm 1827 21 mg mg NNP cord-023095-4dannjjm 1827 22 / / SYM cord-023095-4dannjjm 1827 23 dl dl NNP cord-023095-4dannjjm 1827 24 vs. vs. NNP cord-023095-4dannjjm 1827 25 3.91 3.91 CD cord-023095-4dannjjm 1827 26 [ [ -LRB- cord-023095-4dannjjm 1827 27 3.38 3.38 CD cord-023095-4dannjjm 1827 28 , , , cord-023095-4dannjjm 1827 29 4.37 4.37 CD cord-023095-4dannjjm 1827 30 ] ] -RRB- cord-023095-4dannjjm 1827 31 mg mg NNP cord-023095-4dannjjm 1827 32 / / SYM cord-023095-4dannjjm 1827 33 dl dl NN cord-023095-4dannjjm 1827 34 ; ; : cord-023095-4dannjjm 1827 35 n n NNP cord-023095-4dannjjm 1827 36 5 5 CD cord-023095-4dannjjm 1827 37 13 13 CD cord-023095-4dannjjm 1827 38 , , , cord-023095-4dannjjm 1827 39 P p NN cord-023095-4dannjjm 1827 40 5 5 CD cord-023095-4dannjjm 1827 41 0.01 0.01 CD cord-023095-4dannjjm 1827 42 ) ) -RRB- cord-023095-4dannjjm 1828 1 whereas whereas IN cord-023095-4dannjjm 1828 2 plasma plasma NN cord-023095-4dannjjm 1828 3 phosphate phosphate NN cord-023095-4dannjjm 1828 4 concentrations concentration NNS cord-023095-4dannjjm 1828 5 did do VBD cord-023095-4dannjjm 1828 6 not not RB cord-023095-4dannjjm 1828 7 change change VB cord-023095-4dannjjm 1828 8 significantly significantly RB cord-023095-4dannjjm 1828 9 following follow VBG cord-023095-4dannjjm 1828 10 treatment treatment NN cord-023095-4dannjjm 1828 11 in in IN cord-023095-4dannjjm 1828 12 cats cat NNS cord-023095-4dannjjm 1828 13 that that WDT cord-023095-4dannjjm 1828 14 did do VBD cord-023095-4dannjjm 1828 15 develop develop VB cord-023095-4dannjjm 1828 16 azotemia azotemia NN cord-023095-4dannjjm 1828 17 ( ( -LRB- cord-023095-4dannjjm 1828 18 4.28 4.28 CD cord-023095-4dannjjm 1828 19 [ [ -LRB- cord-023095-4dannjjm 1828 20 3.81 3.81 CD cord-023095-4dannjjm 1828 21 , , , cord-023095-4dannjjm 1828 22 5.64 5.64 CD cord-023095-4dannjjm 1828 23 ] ] -RRB- cord-023095-4dannjjm 1829 1 mg/ mg/ NNP cord-023095-4dannjjm 1829 2 dl dl NNP cord-023095-4dannjjm 1829 3 vs. vs. NNP cord-023095-4dannjjm 1829 4 4.22 4.22 CD cord-023095-4dannjjm 1829 5 [ [ -LRB- cord-023095-4dannjjm 1829 6 3.10 3.10 CD cord-023095-4dannjjm 1829 7 , , , cord-023095-4dannjjm 1829 8 5.33 5.33 CD cord-023095-4dannjjm 1829 9 ] ] -RRB- cord-023095-4dannjjm 1829 10 mg mg NNP cord-023095-4dannjjm 1829 11 / / SYM cord-023095-4dannjjm 1829 12 dl dl NN cord-023095-4dannjjm 1829 13 ; ; : cord-023095-4dannjjm 1830 1 n n NN cord-023095-4dannjjm 1830 2 5 5 CD cord-023095-4dannjjm 1830 3 14 14 CD cord-023095-4dannjjm 1830 4 , , , cord-023095-4dannjjm 1830 5 P p NN cord-023095-4dannjjm 1830 6 5 5 CD cord-023095-4dannjjm 1830 7 0.158 0.158 CD cord-023095-4dannjjm 1830 8 ) ) -RRB- cord-023095-4dannjjm 1830 9 . . . cord-023095-4dannjjm 1831 1 Plasma plasma NN cord-023095-4dannjjm 1831 2 FGF-23 FGF-23 NNP cord-023095-4dannjjm 1831 3 concentrations concentration NNS cord-023095-4dannjjm 1831 4 were be VBD cord-023095-4dannjjm 1831 5 significantly significantly RB cord-023095-4dannjjm 1831 6 higher high JJR cord-023095-4dannjjm 1831 7 in in IN cord-023095-4dannjjm 1831 8 cats cat NNS cord-023095-4dannjjm 1831 9 that that WDT cord-023095-4dannjjm 1831 10 developed develop VBD cord-023095-4dannjjm 1831 11 azotemia azotemia NN cord-023095-4dannjjm 1831 12 than than IN cord-023095-4dannjjm 1831 13 cats cat NNS cord-023095-4dannjjm 1831 14 that that WDT cord-023095-4dannjjm 1831 15 did do VBD cord-023095-4dannjjm 1831 16 not not RB cord-023095-4dannjjm 1831 17 at at IN cord-023095-4dannjjm 1831 18 both both DT cord-023095-4dannjjm 1831 19 pre pre JJ cord-023095-4dannjjm 1831 20 treatment treatment NN cord-023095-4dannjjm 1831 21 ( ( -LRB- cord-023095-4dannjjm 1831 22 211.7 211.7 CD cord-023095-4dannjjm 1831 23 [ [ -LRB- cord-023095-4dannjjm 1831 24 176.4 176.4 CD cord-023095-4dannjjm 1831 25 , , , cord-023095-4dannjjm 1831 26 356 356 CD cord-023095-4dannjjm 1831 27 .3 .3 NN cord-023095-4dannjjm 1831 28 ] ] -RRB- cord-023095-4dannjjm 1832 1 pg pg NNP cord-023095-4dannjjm 1832 2 / / SYM cord-023095-4dannjjm 1832 3 ml ml IN cord-023095-4dannjjm 1832 4 vs. vs. FW cord-023095-4dannjjm 1832 5 148.3 148.3 CD cord-023095-4dannjjm 1832 6 [ [ -LRB- cord-023095-4dannjjm 1832 7 118.8 118.8 CD cord-023095-4dannjjm 1832 8 , , , cord-023095-4dannjjm 1832 9 274 274 CD cord-023095-4dannjjm 1832 10 .9 .9 CD cord-023095-4dannjjm 1832 11 ] ] -RRB- cord-023095-4dannjjm 1833 1 pg pg NNP cord-023095-4dannjjm 1833 2 / / SYM cord-023095-4dannjjm 1833 3 ml ml NN cord-023095-4dannjjm 1833 4 ; ; : cord-023095-4dannjjm 1833 5 P p NN cord-023095-4dannjjm 1833 6 5 5 CD cord-023095-4dannjjm 1833 7 0.039 0.039 CD cord-023095-4dannjjm 1833 8 ) ) -RRB- cord-023095-4dannjjm 1833 9 and and CC cord-023095-4dannjjm 1833 10 post post JJ cord-023095-4dannjjm 1833 11 treatment treatment NN cord-023095-4dannjjm 1833 12 ( ( -LRB- cord-023095-4dannjjm 1833 13 514.0 514.0 CD cord-023095-4dannjjm 1833 14 [ [ -LRB- cord-023095-4dannjjm 1833 15 250.2 250.2 CD cord-023095-4dannjjm 1833 16 , , , cord-023095-4dannjjm 1833 17 800.0 800.0 CD cord-023095-4dannjjm 1833 18 ] ] -RRB- cord-023095-4dannjjm 1833 19 pg pg NNS cord-023095-4dannjjm 1833 20 / / SYM cord-023095-4dannjjm 1833 21 ml ml NNS cord-023095-4dannjjm 1833 22 vs. vs. IN cord-023095-4dannjjm 1833 23 195.1 195.1 CD cord-023095-4dannjjm 1833 24 [ [ -LRB- cord-023095-4dannjjm 1833 25 160.7 160.7 CD cord-023095-4dannjjm 1833 26 , , , cord-023095-4dannjjm 1833 27 287 287 CD cord-023095-4dannjjm 1833 28 .3 .3 CD cord-023095-4dannjjm 1833 29 ] ] -RRB- cord-023095-4dannjjm 1834 1 pg pg NNP cord-023095-4dannjjm 1834 2 / / SYM cord-023095-4dannjjm 1834 3 ml ml NN cord-023095-4dannjjm 1834 4 ; ; : cord-023095-4dannjjm 1834 5 P p NN cord-023095-4dannjjm 1834 6 5 5 CD cord-023095-4dannjjm 1834 7 0.001 0.001 CD cord-023095-4dannjjm 1834 8 ) ) -RRB- cord-023095-4dannjjm 1834 9 timepoints timepoint NNS cord-023095-4dannjjm 1834 10 . . . cord-023095-4dannjjm 1835 1 Plasma plasma NN cord-023095-4dannjjm 1835 2 FGF-23 FGF-23 NNP cord-023095-4dannjjm 1835 3 concentrations concentration NNS cord-023095-4dannjjm 1835 4 increased increase VBD cord-023095-4dannjjm 1835 5 following follow VBG cord-023095-4dannjjm 1835 6 treatment treatment NN cord-023095-4dannjjm 1835 7 in in IN cord-023095-4dannjjm 1835 8 both both DT cord-023095-4dannjjm 1835 9 azotemic azotemic NNS cord-023095-4dannjjm 1835 10 ( ( -LRB- cord-023095-4dannjjm 1835 11 P p NN cord-023095-4dannjjm 1835 12 5 5 CD cord-023095-4dannjjm 1835 13 0.004 0.004 CD cord-023095-4dannjjm 1835 14 ) ) -RRB- cord-023095-4dannjjm 1835 15 and and CC cord-023095-4dannjjm 1835 16 non non JJ cord-023095-4dannjjm 1835 17 - - JJ cord-023095-4dannjjm 1835 18 azotemic azotemic JJ cord-023095-4dannjjm 1835 19 groups group NNS cord-023095-4dannjjm 1835 20 ( ( -LRB- cord-023095-4dannjjm 1835 21 P p NN cord-023095-4dannjjm 1835 22 5 5 CD cord-023095-4dannjjm 1835 23 0.025 0.025 CD cord-023095-4dannjjm 1835 24 ) ) -RRB- cord-023095-4dannjjm 1835 25 . . . cord-023095-4dannjjm 1836 1 Plasma plasma NN cord-023095-4dannjjm 1836 2 FGF-23 FGF-23 NNP cord-023095-4dannjjm 1836 3 concentrations concentration NNS cord-023095-4dannjjm 1836 4 and and CC cord-023095-4dannjjm 1836 5 plasma plasma NN cord-023095-4dannjjm 1836 6 phosphate phosphate NN cord-023095-4dannjjm 1836 7 concentrations concentration NNS cord-023095-4dannjjm 1836 8 were be VBD cord-023095-4dannjjm 1836 9 not not RB cord-023095-4dannjjm 1836 10 correlated correlate VBN cord-023095-4dannjjm 1836 11 at at IN cord-023095-4dannjjm 1836 12 baseline baseline NN cord-023095-4dannjjm 1836 13 ( ( -LRB- cord-023095-4dannjjm 1836 14 r r NN cord-023095-4dannjjm 1836 15 s s NN cord-023095-4dannjjm 1836 16 5 5 CD cord-023095-4dannjjm 1836 17 0.189 0.189 CD cord-023095-4dannjjm 1836 18 , , , cord-023095-4dannjjm 1836 19 P p NN cord-023095-4dannjjm 1836 20 5 5 CD cord-023095-4dannjjm 1836 21 0.335 0.335 CD cord-023095-4dannjjm 1836 22 ) ) -RRB- cord-023095-4dannjjm 1836 23 or or CC cord-023095-4dannjjm 1836 24 following follow VBG cord-023095-4dannjjm 1836 25 treatment treatment NN cord-023095-4dannjjm 1837 1 ( ( -LRB- cord-023095-4dannjjm 1837 2 r r NNP cord-023095-4dannjjm 1837 3 s s NN cord-023095-4dannjjm 1837 4 5 5 CD cord-023095-4dannjjm 1837 5 0.136 0.136 CD cord-023095-4dannjjm 1837 6 , , , cord-023095-4dannjjm 1837 7 P p NN cord-023095-4dannjjm 1837 8 5 5 CD cord-023095-4dannjjm 1837 9 0.472 0.472 CD cord-023095-4dannjjm 1837 10 ) ) -RRB- cord-023095-4dannjjm 1837 11 . . . cord-023095-4dannjjm 1838 1 Plasma plasma NN cord-023095-4dannjjm 1838 2 FGF-23 FGF-23 NNP cord-023095-4dannjjm 1838 3 concentrations concentration NNS cord-023095-4dannjjm 1838 4 were be VBD cord-023095-4dannjjm 1838 5 higher high JJR cord-023095-4dannjjm 1838 6 in in IN cord-023095-4dannjjm 1838 7 pre pre JJ cord-023095-4dannjjm 1838 8 - - JJ cord-023095-4dannjjm 1838 9 azotemic azotemic JJ cord-023095-4dannjjm 1838 10 cats cat NNS cord-023095-4dannjjm 1838 11 than than IN cord-023095-4dannjjm 1838 12 non non JJ cord-023095-4dannjjm 1838 13 - - JJ cord-023095-4dannjjm 1838 14 azotemic azotemic JJ cord-023095-4dannjjm 1838 15 cats cat NNS cord-023095-4dannjjm 1838 16 and and CC cord-023095-4dannjjm 1838 17 increased increase VBD cord-023095-4dannjjm 1838 18 following follow VBG cord-023095-4dannjjm 1838 19 treatment treatment NN cord-023095-4dannjjm 1838 20 of of IN cord-023095-4dannjjm 1838 21 HTH HTH NNP cord-023095-4dannjjm 1838 22 . . . cord-023095-4dannjjm 1839 1 The the DT cord-023095-4dannjjm 1839 2 reason reason NN cord-023095-4dannjjm 1839 3 that that IN cord-023095-4dannjjm 1839 4 FGF-23 FGF-23 NNP cord-023095-4dannjjm 1839 5 concentrations concentration NNS cord-023095-4dannjjm 1839 6 increased increase VBD cord-023095-4dannjjm 1839 7 following follow VBG cord-023095-4dannjjm 1839 8 treatment treatment NN cord-023095-4dannjjm 1839 9 , , , cord-023095-4dannjjm 1839 10 particularly particularly RB cord-023095-4dannjjm 1839 11 in in IN cord-023095-4dannjjm 1839 12 the the DT cord-023095-4dannjjm 1839 13 face face NN cord-023095-4dannjjm 1839 14 of of IN cord-023095-4dannjjm 1839 15 decreasing decrease VBG cord-023095-4dannjjm 1839 16 plasma plasma NN cord-023095-4dannjjm 1839 17 phosphate phosphate NN cord-023095-4dannjjm 1839 18 concentrations concentration NNS cord-023095-4dannjjm 1839 19 in in IN cord-023095-4dannjjm 1839 20 cats cat NNS cord-023095-4dannjjm 1839 21 that that WDT cord-023095-4dannjjm 1839 22 remain remain VBP cord-023095-4dannjjm 1839 23 non non JJ cord-023095-4dannjjm 1839 24 - - JJ cord-023095-4dannjjm 1839 25 azotemic azotemic JJ cord-023095-4dannjjm 1839 26 , , , cord-023095-4dannjjm 1839 27 is be VBZ cord-023095-4dannjjm 1839 28 unclear unclear JJ cord-023095-4dannjjm 1839 29 but but CC cord-023095-4dannjjm 1839 30 may may MD cord-023095-4dannjjm 1839 31 be be VB cord-023095-4dannjjm 1839 32 related relate VBN cord-023095-4dannjjm 1839 33 to to IN cord-023095-4dannjjm 1839 34 the the DT cord-023095-4dannjjm 1839 35 decline decline NN cord-023095-4dannjjm 1839 36 in in IN cord-023095-4dannjjm 1839 37 glomerular glomerular JJ cord-023095-4dannjjm 1839 38 filtration filtration NN cord-023095-4dannjjm 1839 39 rate rate NN cord-023095-4dannjjm 1839 40 . . . cord-023095-4dannjjm 1840 1 Hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 1840 2 is be VBZ cord-023095-4dannjjm 1840 3 a a DT cord-023095-4dannjjm 1840 4 disorder disorder NN cord-023095-4dannjjm 1840 5 resulting result VBG cord-023095-4dannjjm 1840 6 from from IN cord-023095-4dannjjm 1840 7 the the DT cord-023095-4dannjjm 1840 8 excessive excessive JJ cord-023095-4dannjjm 1840 9 production production NN cord-023095-4dannjjm 1840 10 and and CC cord-023095-4dannjjm 1840 11 secretion secretion NN cord-023095-4dannjjm 1840 12 of of IN cord-023095-4dannjjm 1840 13 T4 T4 NNP cord-023095-4dannjjm 1840 14 and and CC cord-023095-4dannjjm 1840 15 T3 T3 NNP cord-023095-4dannjjm 1840 16 by by IN cord-023095-4dannjjm 1840 17 the the DT cord-023095-4dannjjm 1840 18 thyroid thyroid NN cord-023095-4dannjjm 1840 19 gland gland NN cord-023095-4dannjjm 1840 20 . . . cord-023095-4dannjjm 1841 1 Although although IN cord-023095-4dannjjm 1841 2 the the DT cord-023095-4dannjjm 1841 3 disorder disorder NN cord-023095-4dannjjm 1841 4 and and CC cord-023095-4dannjjm 1841 5 its -PRON- PRP$ cord-023095-4dannjjm 1841 6 pathological pathological JJ cord-023095-4dannjjm 1841 7 lesions lesion NNS cord-023095-4dannjjm 1841 8 have have VBP cord-023095-4dannjjm 1841 9 been be VBN cord-023095-4dannjjm 1841 10 well well RB cord-023095-4dannjjm 1841 11 studied study VBN cord-023095-4dannjjm 1841 12 and and CC cord-023095-4dannjjm 1841 13 described describe VBD cord-023095-4dannjjm 1841 14 the the DT cord-023095-4dannjjm 1841 15 cause cause NN cord-023095-4dannjjm 1841 16 remains remain VBZ cord-023095-4dannjjm 1841 17 illusive illusive JJ cord-023095-4dannjjm 1841 18 . . . cord-023095-4dannjjm 1842 1 Whole whole JJ cord-023095-4dannjjm 1842 2 blood blood NN cord-023095-4dannjjm 1842 3 and and CC cord-023095-4dannjjm 1842 4 solid solid JJ cord-023095-4dannjjm 1842 5 tissue tissue NN cord-023095-4dannjjm 1842 6 samples sample NNS cord-023095-4dannjjm 1842 7 from from IN cord-023095-4dannjjm 1842 8 non non JJ cord-023095-4dannjjm 1842 9 - - JJ cord-023095-4dannjjm 1842 10 diseased diseased JJ cord-023095-4dannjjm 1842 11 , , , cord-023095-4dannjjm 1842 12 severe severe JJ cord-023095-4dannjjm 1842 13 disease disease NN cord-023095-4dannjjm 1842 14 and and CC cord-023095-4dannjjm 1842 15 mild mild JJ cord-023095-4dannjjm 1842 16 disease disease NN cord-023095-4dannjjm 1842 17 cats cat NNS cord-023095-4dannjjm 1842 18 based base VBN cord-023095-4dannjjm 1842 19 on on IN cord-023095-4dannjjm 1842 20 T4 T4 NNP cord-023095-4dannjjm 1842 21 levels level NNS cord-023095-4dannjjm 1842 22 and and CC cord-023095-4dannjjm 1842 23 thyroid thyroid NN cord-023095-4dannjjm 1842 24 histology histology NN cord-023095-4dannjjm 1842 25 were be VBD cord-023095-4dannjjm 1842 26 used use VBN cord-023095-4dannjjm 1842 27 in in IN cord-023095-4dannjjm 1842 28 this this DT cord-023095-4dannjjm 1842 29 study study NN cord-023095-4dannjjm 1842 30 . . . cord-023095-4dannjjm 1843 1 Whole whole JJ cord-023095-4dannjjm 1843 2 blood blood NN cord-023095-4dannjjm 1843 3 samples sample NNS cord-023095-4dannjjm 1843 4 from from IN cord-023095-4dannjjm 1843 5 29 29 CD cord-023095-4dannjjm 1843 6 non non JJ cord-023095-4dannjjm 1843 7 - - JJ cord-023095-4dannjjm 1843 8 disease disease JJ cord-023095-4dannjjm 1843 9 cats cat NNS cord-023095-4dannjjm 1843 10 , , , cord-023095-4dannjjm 1843 11 28 28 CD cord-023095-4dannjjm 1843 12 severe severe JJ cord-023095-4dannjjm 1843 13 disease disease NN cord-023095-4dannjjm 1843 14 cats cat NNS cord-023095-4dannjjm 1843 15 and and CC cord-023095-4dannjjm 1843 16 17 17 CD cord-023095-4dannjjm 1843 17 mild mild JJ cord-023095-4dannjjm 1843 18 disease disease NN cord-023095-4dannjjm 1843 19 cats cat NNS cord-023095-4dannjjm 1843 20 as as RB cord-023095-4dannjjm 1843 21 well well RB cord-023095-4dannjjm 1843 22 as as IN cord-023095-4dannjjm 1843 23 solid solid JJ cord-023095-4dannjjm 1843 24 thyroid thyroid NN cord-023095-4dannjjm 1843 25 tissue tissue NN cord-023095-4dannjjm 1843 26 samples sample NNS cord-023095-4dannjjm 1843 27 from from IN cord-023095-4dannjjm 1843 28 30 30 CD cord-023095-4dannjjm 1843 29 non non JJ cord-023095-4dannjjm 1843 30 - - JJ cord-023095-4dannjjm 1843 31 disease disease JJ cord-023095-4dannjjm 1843 32 cats cat NNS cord-023095-4dannjjm 1843 33 , , , cord-023095-4dannjjm 1843 34 31 31 CD cord-023095-4dannjjm 1843 35 severe severe JJ cord-023095-4dannjjm 1843 36 disease disease NN cord-023095-4dannjjm 1843 37 cats cat NNS cord-023095-4dannjjm 1843 38 and and CC cord-023095-4dannjjm 1843 39 27 27 CD cord-023095-4dannjjm 1843 40 mild mild JJ cord-023095-4dannjjm 1843 41 disease disease NN cord-023095-4dannjjm 1843 42 cats cat NNS cord-023095-4dannjjm 1843 43 were be VBD cord-023095-4dannjjm 1843 44 collected collect VBN cord-023095-4dannjjm 1843 45 and and CC cord-023095-4dannjjm 1843 46 processed process VBN cord-023095-4dannjjm 1843 47 . . . cord-023095-4dannjjm 1844 1 The the DT cord-023095-4dannjjm 1844 2 resulting result VBG cord-023095-4dannjjm 1844 3 total total JJ cord-023095-4dannjjm 1844 4 RNA RNA NNP cord-023095-4dannjjm 1844 5 samples sample NNS cord-023095-4dannjjm 1844 6 were be VBD cord-023095-4dannjjm 1844 7 used use VBN cord-023095-4dannjjm 1844 8 for for IN cord-023095-4dannjjm 1844 9 GeneChip GeneChip NNP cord-023095-4dannjjm 1844 10 analysis analysis NN cord-023095-4dannjjm 1844 11 using use VBG cord-023095-4dannjjm 1844 12 our -PRON- PRP$ cord-023095-4dannjjm 1844 13 custom custom NN cord-023095-4dannjjm 1844 14 feline feline JJ cord-023095-4dannjjm 1844 15 gene gene NN cord-023095-4dannjjm 1844 16 chip chip NN cord-023095-4dannjjm 1844 17 designed design VBN cord-023095-4dannjjm 1844 18 by by IN cord-023095-4dannjjm 1844 19 Affymetrix Affymetrix NNP cord-023095-4dannjjm 1844 20 . . . cord-023095-4dannjjm 1845 1 Data data NN cord-023095-4dannjjm 1845 2 analysis analysis NN cord-023095-4dannjjm 1845 3 was be VBD cord-023095-4dannjjm 1845 4 performed perform VBN cord-023095-4dannjjm 1845 5 using use VBG cord-023095-4dannjjm 1845 6 The the DT cord-023095-4dannjjm 1845 7 Partek Partek NNP cord-023095-4dannjjm 1845 8 s s POS cord-023095-4dannjjm 1845 9 GS GS NNP cord-023095-4dannjjm 1845 10 software software NN cord-023095-4dannjjm 1845 11 for for IN cord-023095-4dannjjm 1845 12 Gene Gene NNP cord-023095-4dannjjm 1845 13 Expression Expression NNP cord-023095-4dannjjm 1845 14 data datum NNS cord-023095-4dannjjm 1845 15 . . . cord-023095-4dannjjm 1846 1 The the DT cord-023095-4dannjjm 1846 2 Robust Robust NNP cord-023095-4dannjjm 1846 3 Multichip Multichip NNP cord-023095-4dannjjm 1846 4 Average average JJ cord-023095-4dannjjm 1846 5 algorithm algorithm NN cord-023095-4dannjjm 1846 6 was be VBD cord-023095-4dannjjm 1846 7 used use VBN cord-023095-4dannjjm 1846 8 for for IN cord-023095-4dannjjm 1846 9 background background NN cord-023095-4dannjjm 1846 10 adjustment adjustment NN cord-023095-4dannjjm 1846 11 , , , cord-023095-4dannjjm 1846 12 normalization normalization NN cord-023095-4dannjjm 1846 13 , , , cord-023095-4dannjjm 1846 14 and and CC cord-023095-4dannjjm 1846 15 probe probe NN cord-023095-4dannjjm 1846 16 - - HYPH cord-023095-4dannjjm 1846 17 level level NN cord-023095-4dannjjm 1846 18 summarization summarization NN cord-023095-4dannjjm 1846 19 of of IN cord-023095-4dannjjm 1846 20 the the DT cord-023095-4dannjjm 1846 21 raw raw JJ cord-023095-4dannjjm 1846 22 data datum NNS cord-023095-4dannjjm 1846 23 . . . cord-023095-4dannjjm 1847 1 ANOVA ANOVA NNP cord-023095-4dannjjm 1847 2 analysis analysis NN cord-023095-4dannjjm 1847 3 was be VBD cord-023095-4dannjjm 1847 4 performed perform VBN cord-023095-4dannjjm 1847 5 to to TO cord-023095-4dannjjm 1847 6 find find VB cord-023095-4dannjjm 1847 7 significant significant JJ cord-023095-4dannjjm 1847 8 differentially differentially RB cord-023095-4dannjjm 1847 9 expressed express VBN cord-023095-4dannjjm 1847 10 genes gene NNS cord-023095-4dannjjm 1847 11 with with IN cord-023095-4dannjjm 1847 12 a a DT cord-023095-4dannjjm 1847 13 minimal minimal JJ cord-023095-4dannjjm 1847 14 False false JJ cord-023095-4dannjjm 1847 15 Discovery discovery NN cord-023095-4dannjjm 1847 16 Rate rate NN cord-023095-4dannjjm 1847 17 control control NN cord-023095-4dannjjm 1847 18 of of IN cord-023095-4dannjjm 1847 19 0.1 0.1 CD cord-023095-4dannjjm 1847 20 and and CC cord-023095-4dannjjm 1847 21 a a DT cord-023095-4dannjjm 1847 22 fold fold JJ cord-023095-4dannjjm 1847 23 change change NN cord-023095-4dannjjm 1847 24 of of IN cord-023095-4dannjjm 1847 25 1.3 1.3 CD cord-023095-4dannjjm 1847 26 in in IN cord-023095-4dannjjm 1847 27 each each DT cord-023095-4dannjjm 1847 28 direction direction NN cord-023095-4dannjjm 1847 29 . . . cord-023095-4dannjjm 1848 1 During during IN cord-023095-4dannjjm 1848 2 the the DT cord-023095-4dannjjm 1848 3 mild mild JJ cord-023095-4dannjjm 1848 4 disease disease NN cord-023095-4dannjjm 1848 5 state state NN cord-023095-4dannjjm 1848 6 , , , cord-023095-4dannjjm 1848 7 pathways pathway NNS cord-023095-4dannjjm 1848 8 associated associate VBN cord-023095-4dannjjm 1848 9 with with IN cord-023095-4dannjjm 1848 10 DNA dna NN cord-023095-4dannjjm 1848 11 damage damage NN cord-023095-4dannjjm 1848 12 and and CC cord-023095-4dannjjm 1848 13 apoptosis apoptosis NN cord-023095-4dannjjm 1848 14 are be VBP cord-023095-4dannjjm 1848 15 most most RBS cord-023095-4dannjjm 1848 16 prominent prominent JJ cord-023095-4dannjjm 1848 17 . . . cord-023095-4dannjjm 1849 1 At at IN cord-023095-4dannjjm 1849 2 later later JJ cord-023095-4dannjjm 1849 3 stages stage NNS cord-023095-4dannjjm 1849 4 when when WRB cord-023095-4dannjjm 1849 5 the the DT cord-023095-4dannjjm 1849 6 histopathological histopathological JJ cord-023095-4dannjjm 1849 7 disease disease NN cord-023095-4dannjjm 1849 8 is be VBZ cord-023095-4dannjjm 1849 9 more more RBR cord-023095-4dannjjm 1849 10 severe severe JJ cord-023095-4dannjjm 1849 11 in in IN cord-023095-4dannjjm 1849 12 addition addition NN cord-023095-4dannjjm 1849 13 to to IN cord-023095-4dannjjm 1849 14 the the DT cord-023095-4dannjjm 1849 15 aforementioned aforementioned JJ cord-023095-4dannjjm 1849 16 pathways pathway NNS cord-023095-4dannjjm 1849 17 others other NNS cord-023095-4dannjjm 1849 18 associated associate VBN cord-023095-4dannjjm 1849 19 with with IN cord-023095-4dannjjm 1849 20 TGF TGF NNP cord-023095-4dannjjm 1849 21 - - HYPH cord-023095-4dannjjm 1849 22 beta beta NN cord-023095-4dannjjm 1849 23 signaling signaling NN cord-023095-4dannjjm 1849 24 , , , cord-023095-4dannjjm 1849 25 cell cell NN cord-023095-4dannjjm 1849 26 adhesion adhesion NN cord-023095-4dannjjm 1849 27 and and CC cord-023095-4dannjjm 1849 28 extracellular extracellular JJ cord-023095-4dannjjm 1849 29 matrix matrix NN cord-023095-4dannjjm 1849 30 remodeling remodeling NN cord-023095-4dannjjm 1850 1 take take VB cord-023095-4dannjjm 1850 2 more more JJR cord-023095-4dannjjm 1850 3 prominence prominence NN cord-023095-4dannjjm 1850 4 . . . cord-023095-4dannjjm 1851 1 The the DT cord-023095-4dannjjm 1851 2 analysis analysis NN cord-023095-4dannjjm 1851 3 of of IN cord-023095-4dannjjm 1851 4 this this DT cord-023095-4dannjjm 1851 5 unique unique JJ cord-023095-4dannjjm 1851 6 data data NN cord-023095-4dannjjm 1851 7 set set NN cord-023095-4dannjjm 1851 8 generated generate VBN cord-023095-4dannjjm 1851 9 from from IN cord-023095-4dannjjm 1851 10 the the DT cord-023095-4dannjjm 1851 11 use use NN cord-023095-4dannjjm 1851 12 of of IN cord-023095-4dannjjm 1851 13 our -PRON- PRP$ cord-023095-4dannjjm 1851 14 proprietary proprietary JJ cord-023095-4dannjjm 1851 15 GeneChip GeneChip NNP cord-023095-4dannjjm 1851 16 revealed reveal VBD cord-023095-4dannjjm 1851 17 molecular molecular JJ cord-023095-4dannjjm 1851 18 mechanisms mechanism NNS cord-023095-4dannjjm 1851 19 that that WDT cord-023095-4dannjjm 1851 20 are be VBP cord-023095-4dannjjm 1851 21 associated associate VBN cord-023095-4dannjjm 1851 22 with with IN cord-023095-4dannjjm 1851 23 the the DT cord-023095-4dannjjm 1851 24 transition transition NN cord-023095-4dannjjm 1851 25 from from IN cord-023095-4dannjjm 1851 26 non non JJ cord-023095-4dannjjm 1851 27 - - JJ cord-023095-4dannjjm 1851 28 disease disease JJ cord-023095-4dannjjm 1851 29 , , , cord-023095-4dannjjm 1851 30 to to IN cord-023095-4dannjjm 1851 31 mild mild JJ cord-023095-4dannjjm 1851 32 disease disease NN cord-023095-4dannjjm 1851 33 to to IN cord-023095-4dannjjm 1851 34 severe severe JJ cord-023095-4dannjjm 1851 35 disease disease NN cord-023095-4dannjjm 1851 36 , , , cord-023095-4dannjjm 1851 37 in in IN cord-023095-4dannjjm 1851 38 the the DT cord-023095-4dannjjm 1851 39 thyroid thyroid NN cord-023095-4dannjjm 1851 40 tissue tissue NN cord-023095-4dannjjm 1851 41 as as RB cord-023095-4dannjjm 1851 42 well well RB cord-023095-4dannjjm 1851 43 as as IN cord-023095-4dannjjm 1851 44 the the DT cord-023095-4dannjjm 1851 45 blood blood NN cord-023095-4dannjjm 1851 46 . . . cord-023095-4dannjjm 1852 1 These these DT cord-023095-4dannjjm 1852 2 mechanisms mechanism NNS cord-023095-4dannjjm 1852 3 could could MD cord-023095-4dannjjm 1852 4 provide provide VB cord-023095-4dannjjm 1852 5 insights insight NNS cord-023095-4dannjjm 1852 6 into into IN cord-023095-4dannjjm 1852 7 the the DT cord-023095-4dannjjm 1852 8 causes cause NNS cord-023095-4dannjjm 1852 9 of of IN cord-023095-4dannjjm 1852 10 the the DT cord-023095-4dannjjm 1852 11 disease disease NN cord-023095-4dannjjm 1852 12 and and CC cord-023095-4dannjjm 1852 13 identify identify VB cord-023095-4dannjjm 1852 14 potential potential JJ cord-023095-4dannjjm 1852 15 new new JJ cord-023095-4dannjjm 1852 16 therapeutic therapeutic JJ cord-023095-4dannjjm 1852 17 and and CC cord-023095-4dannjjm 1852 18 diagnostic diagnostic JJ cord-023095-4dannjjm 1852 19 targets target NNS cord-023095-4dannjjm 1852 20 . . . cord-023095-4dannjjm 1853 1 Although although IN cord-023095-4dannjjm 1853 2 it -PRON- PRP cord-023095-4dannjjm 1853 3 is be VBZ cord-023095-4dannjjm 1853 4 well well RB cord-023095-4dannjjm 1853 5 established establish VBN cord-023095-4dannjjm 1853 6 that that IN cord-023095-4dannjjm 1853 7 concurrent concurrent JJ cord-023095-4dannjjm 1853 8 chronic chronic JJ cord-023095-4dannjjm 1853 9 kidney kidney NN cord-023095-4dannjjm 1853 10 disease disease NN cord-023095-4dannjjm 1853 11 ( ( -LRB- cord-023095-4dannjjm 1853 12 CKD CKD NNP cord-023095-4dannjjm 1853 13 ) ) -RRB- cord-023095-4dannjjm 1853 14 develops develop VBZ cord-023095-4dannjjm 1853 15 in in IN cord-023095-4dannjjm 1853 16 about about RB cord-023095-4dannjjm 1853 17 30 30 CD cord-023095-4dannjjm 1853 18 % % NN cord-023095-4dannjjm 1853 19 of of IN cord-023095-4dannjjm 1853 20 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 1853 21 cats cat NNS cord-023095-4dannjjm 1853 22 , , , cord-023095-4dannjjm 1853 23 no no DT cord-023095-4dannjjm 1853 24 one one NN cord-023095-4dannjjm 1853 25 has have VBZ cord-023095-4dannjjm 1853 26 reported report VBN cord-023095-4dannjjm 1853 27 the the DT cord-023095-4dannjjm 1853 28 use use NN cord-023095-4dannjjm 1853 29 of of IN cord-023095-4dannjjm 1853 30 the the DT cord-023095-4dannjjm 1853 31 IRIS IRIS NNP cord-023095-4dannjjm 1853 32 staging staging NN cord-023095-4dannjjm 1853 33 system system NN cord-023095-4dannjjm 1853 34 for for IN cord-023095-4dannjjm 1853 35 CKD CKD NNP cord-023095-4dannjjm 1853 36 before before RB cord-023095-4dannjjm 1853 37 and and CC cord-023095-4dannjjm 1853 38 after after IN cord-023095-4dannjjm 1853 39 treatment treatment NN cord-023095-4dannjjm 1853 40 of of IN cord-023095-4dannjjm 1853 41 these these DT cord-023095-4dannjjm 1853 42 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 1853 43 cats cat NNS cord-023095-4dannjjm 1853 44 . . . cord-023095-4dannjjm 1854 1 The the DT cord-023095-4dannjjm 1854 2 purpose purpose NN cord-023095-4dannjjm 1854 3 of of IN cord-023095-4dannjjm 1854 4 this this DT cord-023095-4dannjjm 1854 5 study study NN cord-023095-4dannjjm 1854 6 was be VBD cord-023095-4dannjjm 1854 7 to to TO cord-023095-4dannjjm 1854 8 compare compare VB cord-023095-4dannjjm 1854 9 the the DT cord-023095-4dannjjm 1854 10 effects effect NNS cord-023095-4dannjjm 1854 11 of of IN cord-023095-4dannjjm 1854 12 treatment treatment NN cord-023095-4dannjjm 1854 13 in in IN cord-023095-4dannjjm 1854 14 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 1854 15 cats cat NNS cord-023095-4dannjjm 1854 16 with with IN cord-023095-4dannjjm 1854 17 known know VBN cord-023095-4dannjjm 1854 18 stage stage NN cord-023095-4dannjjm 1854 19 1 1 CD cord-023095-4dannjjm 1854 20 and and CC cord-023095-4dannjjm 1854 21 2 2 CD cord-023095-4dannjjm 1854 22 CKD CKD NNP cord-023095-4dannjjm 1854 23 in in IN cord-023095-4dannjjm 1854 24 order order NN cord-023095-4dannjjm 1854 25 to to TO cord-023095-4dannjjm 1854 26 determine determine VB cord-023095-4dannjjm 1854 27 the the DT cord-023095-4dannjjm 1854 28 effects effect NNS cord-023095-4dannjjm 1854 29 of of IN cord-023095-4dannjjm 1854 30 restoring restore VBG cord-023095-4dannjjm 1854 31 euthyroidism euthyroidism NN cord-023095-4dannjjm 1854 32 or or CC cord-023095-4dannjjm 1854 33 inducing inducing JJ cord-023095-4dannjjm 1854 34 hypothyroidism hypothyroidism NN cord-023095-4dannjjm 1854 35 has have VBZ cord-023095-4dannjjm 1854 36 on on IN cord-023095-4dannjjm 1854 37 the the DT cord-023095-4dannjjm 1854 38 IRIS IRIS NNP cord-023095-4dannjjm 1854 39 stage stage NN cord-023095-4dannjjm 1854 40 in in IN cord-023095-4dannjjm 1854 41 these these DT cord-023095-4dannjjm 1854 42 cats cat NNS cord-023095-4dannjjm 1854 43 . . . cord-023095-4dannjjm 1855 1 We -PRON- PRP cord-023095-4dannjjm 1855 2 evaluated evaluate VBD cord-023095-4dannjjm 1855 3 36 36 CD cord-023095-4dannjjm 1855 4 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 1855 5 cats cat NNS cord-023095-4dannjjm 1855 6 ( ( -LRB- cord-023095-4dannjjm 1855 7 median median JJ cord-023095-4dannjjm 1855 8 age age NN cord-023095-4dannjjm 1855 9 , , , cord-023095-4dannjjm 1855 10 14 14 CD cord-023095-4dannjjm 1855 11 years year NNS cord-023095-4dannjjm 1855 12 ) ) -RRB- cord-023095-4dannjjm 1855 13 in in IN cord-023095-4dannjjm 1855 14 this this DT cord-023095-4dannjjm 1855 15 study study NN cord-023095-4dannjjm 1855 16 . . . cord-023095-4dannjjm 1856 1 One one CD cord-023095-4dannjjm 1856 2 day day NN cord-023095-4dannjjm 1856 3 prior prior RB cord-023095-4dannjjm 1856 4 to to IN cord-023095-4dannjjm 1856 5 treatment treatment NN cord-023095-4dannjjm 1856 6 , , , cord-023095-4dannjjm 1856 7 serum serum NN cord-023095-4dannjjm 1856 8 T t NN cord-023095-4dannjjm 1856 9 4 4 CD cord-023095-4dannjjm 1856 10 concentration concentration NN cord-023095-4dannjjm 1856 11 , , , cord-023095-4dannjjm 1856 12 serum serum NN cord-023095-4dannjjm 1856 13 chemistry chemistry NN cord-023095-4dannjjm 1856 14 analysis analysis NN cord-023095-4dannjjm 1856 15 , , , cord-023095-4dannjjm 1856 16 complete complete JJ cord-023095-4dannjjm 1856 17 urinalysis urinalysis NN cord-023095-4dannjjm 1856 18 , , , cord-023095-4dannjjm 1856 19 and and CC cord-023095-4dannjjm 1856 20 urine urine NN cord-023095-4dannjjm 1856 21 protein protein NN cord-023095-4dannjjm 1856 22 - - HYPH cord-023095-4dannjjm 1856 23 to to IN cord-023095-4dannjjm 1856 24 - - HYPH cord-023095-4dannjjm 1856 25 creatinine creatinine NN cord-023095-4dannjjm 1856 26 ratio ratio NN cord-023095-4dannjjm 1856 27 ( ( -LRB- cord-023095-4dannjjm 1856 28 UPC UPC NNP cord-023095-4dannjjm 1856 29 ) ) -RRB- cord-023095-4dannjjm 1856 30 were be VBD cord-023095-4dannjjm 1856 31 measured measure VBN cord-023095-4dannjjm 1856 32 . . . cord-023095-4dannjjm 1857 1 All all DT cord-023095-4dannjjm 1857 2 cats cat NNS cord-023095-4dannjjm 1857 3 were be VBD cord-023095-4dannjjm 1857 4 again again RB cord-023095-4dannjjm 1857 5 evaluated evaluate VBN cord-023095-4dannjjm 1857 6 with with IN cord-023095-4dannjjm 1857 7 the the DT cord-023095-4dannjjm 1857 8 same same JJ cord-023095-4dannjjm 1857 9 parameters parameter NNS cord-023095-4dannjjm 1857 10 again again RB cord-023095-4dannjjm 1857 11 3 3 CD cord-023095-4dannjjm 1857 12 months month NNS cord-023095-4dannjjm 1857 13 after after IN cord-023095-4dannjjm 1857 14 treatment treatment NN cord-023095-4dannjjm 1857 15 with with IN cord-023095-4dannjjm 1857 16 131 131 CD cord-023095-4dannjjm 1857 17 I. i. NN cord-023095-4dannjjm 1857 18 Prior Prior NNP cord-023095-4dannjjm 1857 19 to to IN cord-023095-4dannjjm 1857 20 treatment treatment NN cord-023095-4dannjjm 1857 21 , , , cord-023095-4dannjjm 1857 22 26 26 CD cord-023095-4dannjjm 1857 23 ( ( -LRB- cord-023095-4dannjjm 1857 24 72 72 CD cord-023095-4dannjjm 1857 25 % % NN cord-023095-4dannjjm 1857 26 ) ) -RRB- cord-023095-4dannjjm 1857 27 of of IN cord-023095-4dannjjm 1857 28 the the DT cord-023095-4dannjjm 1857 29 36 36 CD cord-023095-4dannjjm 1857 30 cats cat NNS cord-023095-4dannjjm 1857 31 had have VBD cord-023095-4dannjjm 1857 32 no no DT cord-023095-4dannjjm 1857 33 evidence evidence NN cord-023095-4dannjjm 1857 34 of of IN cord-023095-4dannjjm 1857 35 azotemia azotemia NNP cord-023095-4dannjjm 1857 36 ( ( -LRB- cord-023095-4dannjjm 1857 37 serum serum NN cord-023095-4dannjjm 1857 38 creatinine creatinine NN cord-023095-4dannjjm 1857 39 o o NNP cord-023095-4dannjjm 1857 40 1.6 1.6 CD cord-023095-4dannjjm 1857 41 mg mg NNP cord-023095-4dannjjm 1857 42 / / SYM cord-023095-4dannjjm 1857 43 dl dl NNP cord-023095-4dannjjm 1857 44 ) ) -RRB- cord-023095-4dannjjm 1857 45 , , , cord-023095-4dannjjm 1857 46 whereas whereas IN cord-023095-4dannjjm 1857 47 10 10 CD cord-023095-4dannjjm 1857 48 cats cat NNS cord-023095-4dannjjm 1857 49 ( ( -LRB- cord-023095-4dannjjm 1857 50 28 28 CD cord-023095-4dannjjm 1857 51 % % NN cord-023095-4dannjjm 1857 52 ) ) -RRB- cord-023095-4dannjjm 1857 53 had have VBD cord-023095-4dannjjm 1857 54 stage stage NN cord-023095-4dannjjm 1857 55 2 2 CD cord-023095-4dannjjm 1857 56 CKD CKD NNP cord-023095-4dannjjm 1857 57 ( ( -LRB- cord-023095-4dannjjm 1857 58 serum serum NN cord-023095-4dannjjm 1857 59 creatinine creatinine NN cord-023095-4dannjjm 1857 60 , , , cord-023095-4dannjjm 1857 61 1.6 1.6 CD cord-023095-4dannjjm 1857 62 - - SYM cord-023095-4dannjjm 1857 63 2.8 2.8 CD cord-023095-4dannjjm 1857 64 mg mg NNP cord-023095-4dannjjm 1857 65 / / SYM cord-023095-4dannjjm 1857 66 dl dl NNP cord-023095-4dannjjm 1857 67 ) ) -RRB- cord-023095-4dannjjm 1857 68 . . . cord-023095-4dannjjm 1858 1 In in IN cord-023095-4dannjjm 1858 2 the the DT cord-023095-4dannjjm 1858 3 36 36 CD cord-023095-4dannjjm 1858 4 cats cat NNS cord-023095-4dannjjm 1858 5 , , , cord-023095-4dannjjm 1858 6 IRIS IRIS NNP cord-023095-4dannjjm 1858 7 staging stage VBG cord-023095-4dannjjm 1858 8 revealed reveal VBD cord-023095-4dannjjm 1858 9 proteinuria proteinuria NN cord-023095-4dannjjm 1858 10 in in IN cord-023095-4dannjjm 1858 11 33 33 CD cord-023095-4dannjjm 1858 12 cats cat NNS cord-023095-4dannjjm 1858 13 ( ( -LRB- cord-023095-4dannjjm 1858 14 92 92 CD cord-023095-4dannjjm 1858 15 % % NN cord-023095-4dannjjm 1858 16 ) ) -RRB- cord-023095-4dannjjm 1858 17 , , , cord-023095-4dannjjm 1858 18 21 21 CD cord-023095-4dannjjm 1858 19 with with IN cord-023095-4dannjjm 1858 20 borderline borderline JJ cord-023095-4dannjjm 1858 21 proteinuria proteinuria NN cord-023095-4dannjjm 1858 22 ( ( -LRB- cord-023095-4dannjjm 1858 23 UPC UPC NNP cord-023095-4dannjjm 1858 24 , , , cord-023095-4dannjjm 1858 25 0.2 0.2 CD cord-023095-4dannjjm 1858 26 - - SYM cord-023095-4dannjjm 1858 27 0.4 0.4 CD cord-023095-4dannjjm 1858 28 ) ) -RRB- cord-023095-4dannjjm 1858 29 and and CC cord-023095-4dannjjm 1858 30 12 12 CD cord-023095-4dannjjm 1858 31 with with IN cord-023095-4dannjjm 1858 32 overt overt JJ cord-023095-4dannjjm 1858 33 proteinuria proteinuria NN cord-023095-4dannjjm 1858 34 ( ( -LRB- cord-023095-4dannjjm 1858 35 UPC UPC NNP cord-023095-4dannjjm 1858 36 4 4 CD cord-023095-4dannjjm 1858 37 0.4 0.4 CD cord-023095-4dannjjm 1858 38 ) ) -RRB- cord-023095-4dannjjm 1858 39 . . . cord-023095-4dannjjm 1859 1 Hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 1859 2 was be VBD cord-023095-4dannjjm 1859 3 cured cure VBN cord-023095-4dannjjm 1859 4 in in IN cord-023095-4dannjjm 1859 5 all all DT cord-023095-4dannjjm 1859 6 36 36 CD cord-023095-4dannjjm 1859 7 cats cat NNS cord-023095-4dannjjm 1859 8 ( ( -LRB- cord-023095-4dannjjm 1859 9 median median JJ cord-023095-4dannjjm 1859 10 post post JJ cord-023095-4dannjjm 1859 11 - - JJ cord-023095-4dannjjm 1859 12 T4 T4 NNP cord-023095-4dannjjm 1859 13 , , , cord-023095-4dannjjm 1859 14 1.3 1.3 CD cord-023095-4dannjjm 1859 15 mg mg NNP cord-023095-4dannjjm 1859 16 / / SYM cord-023095-4dannjjm 1859 17 dl dl NNP cord-023095-4dannjjm 1859 18 ) ) -RRB- cord-023095-4dannjjm 1859 19 . . . cord-023095-4dannjjm 1860 1 All all DT cord-023095-4dannjjm 1860 2 cats cat NNS cord-023095-4dannjjm 1860 3 had have VBD cord-023095-4dannjjm 1860 4 a a DT cord-023095-4dannjjm 1860 5 good good JJ cord-023095-4dannjjm 1860 6 response response NN cord-023095-4dannjjm 1860 7 to to IN cord-023095-4dannjjm 1860 8 treatment treatment NN cord-023095-4dannjjm 1860 9 ; ; : cord-023095-4dannjjm 1860 10 there there EX cord-023095-4dannjjm 1860 11 were be VBD cord-023095-4dannjjm 1860 12 no no DT cord-023095-4dannjjm 1860 13 signs sign NNS cord-023095-4dannjjm 1860 14 of of IN cord-023095-4dannjjm 1860 15 CKD CKD NNP cord-023095-4dannjjm 1860 16 except except IN cord-023095-4dannjjm 1860 17 for for IN cord-023095-4dannjjm 1860 18 polyuria polyuria NN cord-023095-4dannjjm 1860 19 and and CC cord-023095-4dannjjm 1860 20 polydipsia polydipsia NN cord-023095-4dannjjm 1860 21 in in IN cord-023095-4dannjjm 1860 22 some some DT cord-023095-4dannjjm 1860 23 cats cat NNS cord-023095-4dannjjm 1860 24 . . . cord-023095-4dannjjm 1861 1 A a DT cord-023095-4dannjjm 1861 2 significant significant JJ cord-023095-4dannjjm 1861 3 ( ( -LRB- cord-023095-4dannjjm 1861 4 P p NN cord-023095-4dannjjm 1861 5 o o NN cord-023095-4dannjjm 1861 6 0.001 0.001 CD cord-023095-4dannjjm 1861 7 ) ) -RRB- cord-023095-4dannjjm 1861 8 increase increase NN cord-023095-4dannjjm 1861 9 in in IN cord-023095-4dannjjm 1861 10 median median JJ cord-023095-4dannjjm 1861 11 values value NNS cord-023095-4dannjjm 1861 12 for for IN cord-023095-4dannjjm 1861 13 both both DT cord-023095-4dannjjm 1861 14 serum serum NN cord-023095-4dannjjm 1861 15 urea urea NN cord-023095-4dannjjm 1861 16 nitrogen nitrogen NN cord-023095-4dannjjm 1861 17 ( ( -LRB- cord-023095-4dannjjm 1861 18 26 26 CD cord-023095-4dannjjm 1861 19 mg mg NNP cord-023095-4dannjjm 1861 20 / / SYM cord-023095-4dannjjm 1861 21 dl dl NNP cord-023095-4dannjjm 1861 22 to to IN cord-023095-4dannjjm 1861 23 31 31 CD cord-023095-4dannjjm 1861 24 mg mg NNP cord-023095-4dannjjm 1861 25 / / SYM cord-023095-4dannjjm 1861 26 dl dl NNP cord-023095-4dannjjm 1861 27 ) ) -RRB- cord-023095-4dannjjm 1861 28 ) ) -RRB- cord-023095-4dannjjm 1861 29 and and CC cord-023095-4dannjjm 1861 30 creatinine creatinine NN cord-023095-4dannjjm 1861 31 ( ( -LRB- cord-023095-4dannjjm 1861 32 1.1 1.1 CD cord-023095-4dannjjm 1861 33 to to TO cord-023095-4dannjjm 1861 34 1.7 1.7 CD cord-023095-4dannjjm 1861 35 mg mg NNP cord-023095-4dannjjm 1861 36 / / SYM cord-023095-4dannjjm 1861 37 dl dl NNP cord-023095-4dannjjm 1861 38 ) ) -RRB- cord-023095-4dannjjm 1861 39 occurred occur VBD cord-023095-4dannjjm 1861 40 after after IN cord-023095-4dannjjm 1861 41 treatment treatment NN cord-023095-4dannjjm 1861 42 . . . cord-023095-4dannjjm 1862 1 Nine nine CD cord-023095-4dannjjm 1862 2 of of IN cord-023095-4dannjjm 1862 3 the the DT cord-023095-4dannjjm 1862 4 26 26 CD cord-023095-4dannjjm 1862 5 cats cat NNS cord-023095-4dannjjm 1862 6 ( ( -LRB- cord-023095-4dannjjm 1862 7 34.6 34.6 CD cord-023095-4dannjjm 1862 8 % % NN cord-023095-4dannjjm 1862 9 ) ) -RRB- cord-023095-4dannjjm 1862 10 classified classify VBN cord-023095-4dannjjm 1862 11 as as IN cord-023095-4dannjjm 1862 12 nonazotemic nonazotemic JJ cord-023095-4dannjjm 1862 13 or or CC cord-023095-4dannjjm 1862 14 IRIS IRIS NNP cord-023095-4dannjjm 1862 15 stage stage NN cord-023095-4dannjjm 1862 16 1 1 CD cord-023095-4dannjjm 1862 17 prior prior RB cord-023095-4dannjjm 1862 18 to to IN cord-023095-4dannjjm 1862 19 131 131 CD cord-023095-4dannjjm 1863 1 I -PRON- PRP cord-023095-4dannjjm 1863 2 progressed progress VBD cord-023095-4dannjjm 1863 3 to to TO cord-023095-4dannjjm 1863 4 stage stage VB cord-023095-4dannjjm 1863 5 2 2 CD cord-023095-4dannjjm 1863 6 CKD CKD NNP cord-023095-4dannjjm 1863 7 after after IN cord-023095-4dannjjm 1863 8 131 131 CD cord-023095-4dannjjm 1863 9 I. i. NN cord-023095-4dannjjm 1864 1 All all DT cord-023095-4dannjjm 1864 2 10 10 CD cord-023095-4dannjjm 1864 3 cats cat NNS cord-023095-4dannjjm 1864 4 with with IN cord-023095-4dannjjm 1864 5 stage stage NN cord-023095-4dannjjm 1864 6 2 2 CD cord-023095-4dannjjm 1864 7 CKD CKD NNP cord-023095-4dannjjm 1864 8 before before IN cord-023095-4dannjjm 1864 9 treatment treatment NN cord-023095-4dannjjm 1864 10 remained remain VBD cord-023095-4dannjjm 1864 11 azotemic azotemic JJ cord-023095-4dannjjm 1864 12 after after IN cord-023095-4dannjjm 1864 13 131 131 CD cord-023095-4dannjjm 1864 14 I I NNP cord-023095-4dannjjm 1864 15 , , , cord-023095-4dannjjm 1864 16 with with IN cord-023095-4dannjjm 1864 17 5 5 CD cord-023095-4dannjjm 1864 18 cats cat NNS cord-023095-4dannjjm 1864 19 remaining remain VBG cord-023095-4dannjjm 1864 20 in in IN cord-023095-4dannjjm 1864 21 stage stage NN cord-023095-4dannjjm 1864 22 2 2 CD cord-023095-4dannjjm 1864 23 CKD CKD NNP cord-023095-4dannjjm 1864 24 , , , cord-023095-4dannjjm 1864 25 and and CC cord-023095-4dannjjm 1864 26 4 4 CD cord-023095-4dannjjm 1864 27 cats cat NNS cord-023095-4dannjjm 1864 28 progressing progress VBG cord-023095-4dannjjm 1864 29 to to IN cord-023095-4dannjjm 1864 30 stage stage VB cord-023095-4dannjjm 1864 31 3 3 CD cord-023095-4dannjjm 1864 32 CKD CKD NNP cord-023095-4dannjjm 1864 33 ( ( -LRB- cord-023095-4dannjjm 1864 34 serum serum NN cord-023095-4dannjjm 1864 35 creatinine creatinine NN cord-023095-4dannjjm 1864 36 , , , cord-023095-4dannjjm 1864 37 3.1 3.1 CD cord-023095-4dannjjm 1864 38 - - SYM cord-023095-4dannjjm 1864 39 3.7 3.7 CD cord-023095-4dannjjm 1864 40 mg mg NNP cord-023095-4dannjjm 1864 41 / / SYM cord-023095-4dannjjm 1864 42 dl dl NN cord-023095-4dannjjm 1864 43 ) ) -RRB- cord-023095-4dannjjm 1864 44 . . . cord-023095-4dannjjm 1865 1 There there EX cord-023095-4dannjjm 1865 2 was be VBD cord-023095-4dannjjm 1865 3 a a DT cord-023095-4dannjjm 1865 4 significant significant JJ cord-023095-4dannjjm 1865 5 inverse inverse NN cord-023095-4dannjjm 1865 6 relationship relationship NN cord-023095-4dannjjm 1865 7 ( ( -LRB- cord-023095-4dannjjm 1865 8 P p NN cord-023095-4dannjjm 1865 9 5 5 CD cord-023095-4dannjjm 1865 10 0.002 0.002 CD cord-023095-4dannjjm 1865 11 ) ) -RRB- cord-023095-4dannjjm 1865 12 between between IN cord-023095-4dannjjm 1865 13 pretreatment pretreatment NN cord-023095-4dannjjm 1865 14 urine urine NN cord-023095-4dannjjm 1865 15 specific specific JJ cord-023095-4dannjjm 1865 16 gravity gravity NN cord-023095-4dannjjm 1865 17 ( ( -LRB- cord-023095-4dannjjm 1865 18 USG USG NNP cord-023095-4dannjjm 1865 19 ) ) -RRB- cord-023095-4dannjjm 1865 20 and and CC cord-023095-4dannjjm 1865 21 post post JJ cord-023095-4dannjjm 1865 22 - - JJ cord-023095-4dannjjm 1865 23 treatment treatment JJ cord-023095-4dannjjm 1865 24 serum serum NN cord-023095-4dannjjm 1865 25 creatinine creatinine NN cord-023095-4dannjjm 1865 26 in in IN cord-023095-4dannjjm 1865 27 the the DT cord-023095-4dannjjm 1865 28 36 36 CD cord-023095-4dannjjm 1865 29 cats cat NNS cord-023095-4dannjjm 1865 30 . . . cord-023095-4dannjjm 1866 1 Of of IN cord-023095-4dannjjm 1866 2 the the DT cord-023095-4dannjjm 1866 3 19 19 CD cord-023095-4dannjjm 1866 4 cats cat NNS cord-023095-4dannjjm 1866 5 with with IN cord-023095-4dannjjm 1866 6 post post JJ cord-023095-4dannjjm 1866 7 - - JJ cord-023095-4dannjjm 1866 8 treatment treatment JJ cord-023095-4dannjjm 1866 9 serum serum NN cord-023095-4dannjjm 1866 10 creatinine creatinine NN cord-023095-4dannjjm 1866 11 values value NNS cord-023095-4dannjjm 1866 12 4 4 CD cord-023095-4dannjjm 1866 13 1.5 1.5 CD cord-023095-4dannjjm 1866 14 mg mg NNP cord-023095-4dannjjm 1866 15 / / SYM cord-023095-4dannjjm 1866 16 dl dl NNP cord-023095-4dannjjm 1866 17 ( ( -LRB- cord-023095-4dannjjm 1866 18 stage stage NN cord-023095-4dannjjm 1866 19 2 2 CD cord-023095-4dannjjm 1866 20 to to IN cord-023095-4dannjjm 1866 21 3 3 CD cord-023095-4dannjjm 1866 22 CKD CKD NNP cord-023095-4dannjjm 1866 23 ) ) -RRB- cord-023095-4dannjjm 1866 24 , , , cord-023095-4dannjjm 1866 25 15 15 CD cord-023095-4dannjjm 1866 26 ( ( -LRB- cord-023095-4dannjjm 1866 27 79 79 CD cord-023095-4dannjjm 1866 28 % % NN cord-023095-4dannjjm 1866 29 ) ) -RRB- cord-023095-4dannjjm 1866 30 had have VBD cord-023095-4dannjjm 1866 31 pretreatment pretreatment NN cord-023095-4dannjjm 1866 32 USG USG NNP cord-023095-4dannjjm 1866 33 of of IN cord-023095-4dannjjm 1866 34 o o CD cord-023095-4dannjjm 1866 35 1.040 1.040 CD cord-023095-4dannjjm 1866 36 . . . cord-023095-4dannjjm 1867 1 In in IN cord-023095-4dannjjm 1867 2 contrast contrast NN cord-023095-4dannjjm 1867 3 , , , cord-023095-4dannjjm 1867 4 in in IN cord-023095-4dannjjm 1867 5 the the DT cord-023095-4dannjjm 1867 6 17 17 CD cord-023095-4dannjjm 1867 7 cats cat NNS cord-023095-4dannjjm 1867 8 with with IN cord-023095-4dannjjm 1867 9 post post JJ cord-023095-4dannjjm 1867 10 - - JJ cord-023095-4dannjjm 1867 11 treatment treatment JJ cord-023095-4dannjjm 1867 12 serum serum NN cord-023095-4dannjjm 1867 13 creatinine creatinine NN cord-023095-4dannjjm 1867 14 values value NNS cord-023095-4dannjjm 1867 15 o o CD cord-023095-4dannjjm 1867 16 1.5 1.5 CD cord-023095-4dannjjm 1867 17 mg mg NNP cord-023095-4dannjjm 1867 18 / / SYM cord-023095-4dannjjm 1867 19 dl dl NNP cord-023095-4dannjjm 1867 20 , , , cord-023095-4dannjjm 1867 21 only only RB cord-023095-4dannjjm 1867 22 3 3 CD cord-023095-4dannjjm 1867 23 ( ( -LRB- cord-023095-4dannjjm 1867 24 18 18 CD cord-023095-4dannjjm 1867 25 % % NN cord-023095-4dannjjm 1867 26 ) ) -RRB- cord-023095-4dannjjm 1867 27 had have VBD cord-023095-4dannjjm 1867 28 pretreatment pretreatment NN cord-023095-4dannjjm 1867 29 USG USG NNP cord-023095-4dannjjm 1867 30 of of IN cord-023095-4dannjjm 1867 31 o o CD cord-023095-4dannjjm 1867 32 1.040 1.040 CD cord-023095-4dannjjm 1867 33 . . . cord-023095-4dannjjm 1868 1 A a DT cord-023095-4dannjjm 1868 2 significant significant JJ cord-023095-4dannjjm 1868 3 ( ( -LRB- cord-023095-4dannjjm 1868 4 P p NN cord-023095-4dannjjm 1868 5 o o NN cord-023095-4dannjjm 1868 6 0.001 0.001 CD cord-023095-4dannjjm 1868 7 ) ) -RRB- cord-023095-4dannjjm 1868 8 decrease decrease NN cord-023095-4dannjjm 1868 9 in in IN cord-023095-4dannjjm 1868 10 median median JJ cord-023095-4dannjjm 1868 11 UPC UPC NNP cord-023095-4dannjjm 1868 12 from from IN cord-023095-4dannjjm 1868 13 0.3 0.3 CD cord-023095-4dannjjm 1868 14 to to IN cord-023095-4dannjjm 1868 15 0.1 0.1 CD cord-023095-4dannjjm 1868 16 occurred occur VBD cord-023095-4dannjjm 1868 17 after after IN cord-023095-4dannjjm 1868 18 treatment treatment NN cord-023095-4dannjjm 1868 19 , , , cord-023095-4dannjjm 1868 20 but but CC cord-023095-4dannjjm 1868 21 there there EX cord-023095-4dannjjm 1868 22 was be VBD cord-023095-4dannjjm 1868 23 no no DT cord-023095-4dannjjm 1868 24 relationship relationship NN cord-023095-4dannjjm 1868 25 between between IN cord-023095-4dannjjm 1868 26 degree degree NN cord-023095-4dannjjm 1868 27 of of IN cord-023095-4dannjjm 1868 28 proteinuria proteinuria NN cord-023095-4dannjjm 1868 29 and and CC cord-023095-4dannjjm 1868 30 IRIS IRIS NNP cord-023095-4dannjjm 1868 31 stage stage NN cord-023095-4dannjjm 1868 32 in in IN cord-023095-4dannjjm 1868 33 these these DT cord-023095-4dannjjm 1868 34 cats cat NNS cord-023095-4dannjjm 1868 35 . . . cord-023095-4dannjjm 1869 1 Two two CD cord-023095-4dannjjm 1869 2 cats cat NNS cord-023095-4dannjjm 1869 3 developed develop VBD cord-023095-4dannjjm 1869 4 iatrogenic iatrogenic JJ cord-023095-4dannjjm 1869 5 hypothyroidism hypothyroidism NN cord-023095-4dannjjm 1869 6 after after IN cord-023095-4dannjjm 1869 7 131 131 CD cord-023095-4dannjjm 1869 8 I i NN cord-023095-4dannjjm 1869 9 , , , cord-023095-4dannjjm 1869 10 diagnosed diagnose VBN cord-023095-4dannjjm 1869 11 by by IN cord-023095-4dannjjm 1869 12 finding find VBG cord-023095-4dannjjm 1869 13 low low JJ cord-023095-4dannjjm 1869 14 serum serum NN cord-023095-4dannjjm 1869 15 T T NNP cord-023095-4dannjjm 1869 16 4 4 CD cord-023095-4dannjjm 1869 17 and and CC cord-023095-4dannjjm 1869 18 high high JJ cord-023095-4dannjjm 1869 19 cTSH cTSH NNP cord-023095-4dannjjm 1869 20 concentrations concentration NNS cord-023095-4dannjjm 1869 21 . . . cord-023095-4dannjjm 1870 1 Both both DT cord-023095-4dannjjm 1870 2 hypothyroid hypothyroid JJ cord-023095-4dannjjm 1870 3 cats cat NNS cord-023095-4dannjjm 1870 4 had have VBD cord-023095-4dannjjm 1870 5 progressed progress VBN cord-023095-4dannjjm 1870 6 from from IN cord-023095-4dannjjm 1870 7 stage stage NN cord-023095-4dannjjm 1870 8 1 1 CD cord-023095-4dannjjm 1870 9 before before IN cord-023095-4dannjjm 1870 10 treatment treatment NN cord-023095-4dannjjm 1870 11 to to IN cord-023095-4dannjjm 1870 12 stage stage VB cord-023095-4dannjjm 1870 13 2 2 CD cord-023095-4dannjjm 1870 14 and and CC cord-023095-4dannjjm 1870 15 3 3 CD cord-023095-4dannjjm 1870 16 CKD CKD NNP cord-023095-4dannjjm 1870 17 , , , cord-023095-4dannjjm 1870 18 respectively respectively RB cord-023095-4dannjjm 1870 19 , , , cord-023095-4dannjjm 1870 20 after after IN cord-023095-4dannjjm 1870 21 131 131 CD cord-023095-4dannjjm 1870 22 I -PRON- PRP cord-023095-4dannjjm 1870 23 ; ; : cord-023095-4dannjjm 1870 24 after after IN cord-023095-4dannjjm 1870 25 thyroxine thyroxine NN cord-023095-4dannjjm 1870 26 replacement replacement NN cord-023095-4dannjjm 1870 27 , , , cord-023095-4dannjjm 1870 28 serum serum NN cord-023095-4dannjjm 1870 29 creatinine creatinine NN cord-023095-4dannjjm 1870 30 decreased decrease VBD cord-023095-4dannjjm 1870 31 to to IN cord-023095-4dannjjm 1870 32 near near JJ cord-023095-4dannjjm 1870 33 pretreatment pretreatment NN cord-023095-4dannjjm 1870 34 concentrations concentration NNS cord-023095-4dannjjm 1870 35 in in IN cord-023095-4dannjjm 1870 36 both both DT cord-023095-4dannjjm 1870 37 cats cat NNS cord-023095-4dannjjm 1870 38 . . . cord-023095-4dannjjm 1871 1 Conclusions conclusion NNS cord-023095-4dannjjm 1871 2 : : : cord-023095-4dannjjm 1872 1 1 1 LS cord-023095-4dannjjm 1872 2 ) ) -RRB- cord-023095-4dannjjm 1872 3 IRIS IRIS NNP cord-023095-4dannjjm 1872 4 stage stage NN cord-023095-4dannjjm 1873 1 2 2 LS cord-023095-4dannjjm 1873 2 CKD CKD NNP cord-023095-4dannjjm 1873 3 is be VBZ cord-023095-4dannjjm 1873 4 common common JJ cord-023095-4dannjjm 1873 5 in in IN cord-023095-4dannjjm 1873 6 untreated untreated JJ cord-023095-4dannjjm 1873 7 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 1873 8 cats cat NNS cord-023095-4dannjjm 1873 9 . . . cord-023095-4dannjjm 1874 1 2 2 LS cord-023095-4dannjjm 1874 2 ) ) -RRB- cord-023095-4dannjjm 1874 3 Progression progression NN cord-023095-4dannjjm 1874 4 to to IN cord-023095-4dannjjm 1874 5 next next RB cord-023095-4dannjjm 1874 6 higher high JJR cord-023095-4dannjjm 1874 7 IRIS IRIS NNP cord-023095-4dannjjm 1874 8 stage stage NN cord-023095-4dannjjm 1874 9 is be VBZ cord-023095-4dannjjm 1874 10 common common JJ cord-023095-4dannjjm 1874 11 after after IN cord-023095-4dannjjm 1874 12 treatment treatment NN cord-023095-4dannjjm 1874 13 , , , cord-023095-4dannjjm 1874 14 but but CC cord-023095-4dannjjm 1874 15 most most JJS cord-023095-4dannjjm 1874 16 cats cat NNS cord-023095-4dannjjm 1874 17 with with IN cord-023095-4dannjjm 1874 18 remain remain VBP cord-023095-4dannjjm 1874 19 relatively relatively RB cord-023095-4dannjjm 1874 20 asymptomatic asymptomatic JJ cord-023095-4dannjjm 1874 21 for for IN cord-023095-4dannjjm 1874 22 CKD CKD NNP cord-023095-4dannjjm 1874 23 . . . cord-023095-4dannjjm 1875 1 3 3 LS cord-023095-4dannjjm 1875 2 ) ) -RRB- cord-023095-4dannjjm 1875 3 USG USG NNP cord-023095-4dannjjm 1875 4 may may MD cord-023095-4dannjjm 1875 5 be be VB cord-023095-4dannjjm 1875 6 helpful helpful JJ cord-023095-4dannjjm 1875 7 in in IN cord-023095-4dannjjm 1875 8 predicting predict VBG cord-023095-4dannjjm 1875 9 which which WDT cord-023095-4dannjjm 1875 10 cat cat NN cord-023095-4dannjjm 1875 11 's 's POS cord-023095-4dannjjm 1875 12 IRIS IRIS NNP cord-023095-4dannjjm 1875 13 stage stage NN cord-023095-4dannjjm 1875 14 will will MD cord-023095-4dannjjm 1875 15 progress progress VB cord-023095-4dannjjm 1875 16 after after IN cord-023095-4dannjjm 1875 17 131 131 CD cord-023095-4dannjjm 1875 18 I. i. NN cord-023095-4dannjjm 1875 19 4 4 CD cord-023095-4dannjjm 1875 20 ) ) -RRB- cord-023095-4dannjjm 1876 1 Iatrogenic iatrogenic JJ cord-023095-4dannjjm 1876 2 hypothyroidism hypothyroidism NN cord-023095-4dannjjm 1876 3 worsens worsen VBZ cord-023095-4dannjjm 1876 4 azotemia azotemia NN cord-023095-4dannjjm 1876 5 , , , cord-023095-4dannjjm 1876 6 an an DT cord-023095-4dannjjm 1876 7 effect effect NN cord-023095-4dannjjm 1876 8 that that WDT cord-023095-4dannjjm 1876 9 appears appear VBZ cord-023095-4dannjjm 1876 10 reversible reversible JJ cord-023095-4dannjjm 1876 11 with with IN cord-023095-4dannjjm 1876 12 replacement replacement NN cord-023095-4dannjjm 1876 13 therapy therapy NN cord-023095-4dannjjm 1876 14 . . . cord-023095-4dannjjm 1877 1 Home home NN cord-023095-4dannjjm 1877 2 blood blood NN cord-023095-4dannjjm 1877 3 glucose glucose NN cord-023095-4dannjjm 1877 4 monitoring monitoring NN cord-023095-4dannjjm 1877 5 ( ( -LRB- cord-023095-4dannjjm 1877 6 HBGM HBGM NNP cord-023095-4dannjjm 1877 7 ) ) -RRB- cord-023095-4dannjjm 1877 8 of of IN cord-023095-4dannjjm 1877 9 diabetic diabetic JJ cord-023095-4dannjjm 1877 10 pets pet NNS cord-023095-4dannjjm 1877 11 is be VBZ cord-023095-4dannjjm 1877 12 likely likely JJ cord-023095-4dannjjm 1877 13 to to TO cord-023095-4dannjjm 1877 14 result result VB cord-023095-4dannjjm 1877 15 in in IN cord-023095-4dannjjm 1877 16 superior superior JJ cord-023095-4dannjjm 1877 17 glycaemic glycaemic JJ cord-023095-4dannjjm 1877 18 control control NN cord-023095-4dannjjm 1877 19 , , , cord-023095-4dannjjm 1877 20 minimizing minimize VBG cord-023095-4dannjjm 1877 21 episodes episode NNS cord-023095-4dannjjm 1877 22 and and CC cord-023095-4dannjjm 1877 23 impact impact NN cord-023095-4dannjjm 1877 24 of of IN cord-023095-4dannjjm 1877 25 dangerous dangerous JJ cord-023095-4dannjjm 1877 26 hypoglycaemia hypoglycaemia NN cord-023095-4dannjjm 1877 27 and and CC cord-023095-4dannjjm 1877 28 reducing reduce VBG cord-023095-4dannjjm 1877 29 costs cost NNS cord-023095-4dannjjm 1877 30 . . . cord-023095-4dannjjm 1878 1 Nevertheless nevertheless RB cord-023095-4dannjjm 1878 2 , , , cord-023095-4dannjjm 1878 3 it -PRON- PRP cord-023095-4dannjjm 1878 4 has have VBZ cord-023095-4dannjjm 1878 5 proven prove VBN cord-023095-4dannjjm 1878 6 difficult difficult JJ cord-023095-4dannjjm 1878 7 to to TO cord-023095-4dannjjm 1878 8 objectively objectively RB cord-023095-4dannjjm 1878 9 establish establish VB cord-023095-4dannjjm 1878 10 a a DT cord-023095-4dannjjm 1878 11 clear clear JJ cord-023095-4dannjjm 1878 12 benefit benefit NN cord-023095-4dannjjm 1878 13 of of IN cord-023095-4dannjjm 1878 14 HBGM HBGM NNS cord-023095-4dannjjm 1878 15 using use VBG cord-023095-4dannjjm 1878 16 biological biological JJ cord-023095-4dannjjm 1878 17 parameters parameter NNS cord-023095-4dannjjm 1878 18 ( ( -LRB- cord-023095-4dannjjm 1878 19 clinical clinical JJ cord-023095-4dannjjm 1878 20 signs sign NNS cord-023095-4dannjjm 1878 21 , , , cord-023095-4dannjjm 1878 22 blood blood NN cord-023095-4dannjjm 1878 23 glucose glucose NN cord-023095-4dannjjm 1878 24 , , , cord-023095-4dannjjm 1878 25 fructosamine fructosamine NN cord-023095-4dannjjm 1878 26 ) ) -RRB- cord-023095-4dannjjm 1878 27 . . . cord-023095-4dannjjm 1879 1 The the DT cord-023095-4dannjjm 1879 2 current current JJ cord-023095-4dannjjm 1879 3 study study NN cord-023095-4dannjjm 1879 4 aimed aim VBN cord-023095-4dannjjm 1879 5 to to TO cord-023095-4dannjjm 1879 6 assess assess VB cord-023095-4dannjjm 1879 7 the the DT cord-023095-4dannjjm 1879 8 impact impact NN cord-023095-4dannjjm 1879 9 of of IN cord-023095-4dannjjm 1879 10 HBGM HBGM NNP cord-023095-4dannjjm 1879 11 on on IN cord-023095-4dannjjm 1879 12 owner owner NN cord-023095-4dannjjm 1879 13 perceived perceive VBN cord-023095-4dannjjm 1879 14 quality quality NN cord-023095-4dannjjm 1879 15 of of IN cord-023095-4dannjjm 1879 16 life life NN cord-023095-4dannjjm 1879 17 ( ( -LRB- cord-023095-4dannjjm 1879 18 QoL QoL NNP cord-023095-4dannjjm 1879 19 ) ) -RRB- cord-023095-4dannjjm 1879 20 aspects aspect NNS cord-023095-4dannjjm 1879 21 of of IN cord-023095-4dannjjm 1879 22 diabetes diabetes NN cord-023095-4dannjjm 1879 23 mellitus mellitus NN cord-023095-4dannjjm 1879 24 ( ( -LRB- cord-023095-4dannjjm 1879 25 DM dm NN cord-023095-4dannjjm 1879 26 ) ) -RRB- cord-023095-4dannjjm 1879 27 treatment treatment NN cord-023095-4dannjjm 1879 28 , , , cord-023095-4dannjjm 1879 29 using use VBG cord-023095-4dannjjm 1879 30 the the DT cord-023095-4dannjjm 1879 31 recently recently RB cord-023095-4dannjjm 1879 32 validated validate VBN cord-023095-4dannjjm 1879 33 psychometric psychometric JJ cord-023095-4dannjjm 1879 34 tool tool NN cord-023095-4dannjjm 1879 35 DIAQoL diaqol NN cord-023095-4dannjjm 1879 36 - - HYPH cord-023095-4dannjjm 1879 37 pet pet NN cord-023095-4dannjjm 1879 38 . . . cord-023095-4dannjjm 1880 1 Owners owner NNS cord-023095-4dannjjm 1880 2 of of IN cord-023095-4dannjjm 1880 3 insulin insulin NN cord-023095-4dannjjm 1880 4 treated treat VBN cord-023095-4dannjjm 1880 5 diabetic diabetic JJ cord-023095-4dannjjm 1880 6 cats cat NNS cord-023095-4dannjjm 1880 7 were be VBD cord-023095-4dannjjm 1880 8 recruited recruit VBN cord-023095-4dannjjm 1880 9 to to TO cord-023095-4dannjjm 1880 10 complete complete VB cord-023095-4dannjjm 1880 11 the the DT cord-023095-4dannjjm 1880 12 29-item 29-item CD cord-023095-4dannjjm 1880 13 tool tool NN cord-023095-4dannjjm 1880 14 , , , cord-023095-4dannjjm 1880 15 evaluating evaluate VBG cord-023095-4dannjjm 1880 16 areas area NNS cord-023095-4dannjjm 1880 17 affecting affect VBG cord-023095-4dannjjm 1880 18 the the DT cord-023095-4dannjjm 1880 19 cat cat NN cord-023095-4dannjjm 1880 20 's 's POS cord-023095-4dannjjm 1880 21 and and CC cord-023095-4dannjjm 1880 22 owner owner NN cord-023095-4dannjjm 1880 23 's 's POS cord-023095-4dannjjm 1880 24 QoL qol NN cord-023095-4dannjjm 1880 25 , , , cord-023095-4dannjjm 1880 26 including include VBG cord-023095-4dannjjm 1880 27 : : : cord-023095-4dannjjm 1880 28 worry worry VB cord-023095-4dannjjm 1880 29 about about IN cord-023095-4dannjjm 1880 30 pet pet NN cord-023095-4dannjjm 1880 31 's 's POS cord-023095-4dannjjm 1880 32 DM dm NN cord-023095-4dannjjm 1880 33 , , , cord-023095-4dannjjm 1880 34 hypoglycaemia hypoglycaemia NN cord-023095-4dannjjm 1880 35 , , , cord-023095-4dannjjm 1880 36 costs cost NNS cord-023095-4dannjjm 1880 37 , , , cord-023095-4dannjjm 1880 38 owner owner NN cord-023095-4dannjjm 1880 39 's 's POS cord-023095-4dannjjm 1880 40 desire desire NN cord-023095-4dannjjm 1880 41 for for IN cord-023095-4dannjjm 1880 42 autonomous autonomous JJ cord-023095-4dannjjm 1880 43 control control NN cord-023095-4dannjjm 1880 44 over over IN cord-023095-4dannjjm 1880 45 the the DT cord-023095-4dannjjm 1880 46 pet pet NN cord-023095-4dannjjm 1880 47 's 's POS cord-023095-4dannjjm 1880 48 DM dm NN cord-023095-4dannjjm 1880 49 , , , cord-023095-4dannjjm 1880 50 etc etc FW cord-023095-4dannjjm 1880 51 . . . cord-023095-4dannjjm 1881 1 Item item NN cord-023095-4dannjjm 1881 2 - - HYPH cord-023095-4dannjjm 1881 3 weighted weight VBN cord-023095-4dannjjm 1881 4 - - HYPH cord-023095-4dannjjm 1881 5 impact impact NN cord-023095-4dannjjm 1881 6 - - HYPH cord-023095-4dannjjm 1881 7 scores score NNS cord-023095-4dannjjm 1881 8 ( ( -LRB- cord-023095-4dannjjm 1881 9 IWIS IWIS NNP cord-023095-4dannjjm 1881 10 ) ) -RRB- cord-023095-4dannjjm 1881 11 , , . cord-023095-4dannjjm 1882 1 reflecting reflect VBG cord-023095-4dannjjm 1882 2 frequency frequency NN cord-023095-4dannjjm 1882 3 and and CC cord-023095-4dannjjm 1882 4 importance importance NN cord-023095-4dannjjm 1882 5 ratings rating NNS cord-023095-4dannjjm 1882 6 of of IN cord-023095-4dannjjm 1882 7 each each DT cord-023095-4dannjjm 1882 8 item item NN cord-023095-4dannjjm 1882 9 , , , cord-023095-4dannjjm 1882 10 were be VBD cord-023095-4dannjjm 1882 11 calculated calculate VBN cord-023095-4dannjjm 1882 12 , , , cord-023095-4dannjjm 1882 13 as as RB cord-023095-4dannjjm 1882 14 well well RB cord-023095-4dannjjm 1882 15 as as IN cord-023095-4dannjjm 1882 16 averageweighted averageweighte VBN cord-023095-4dannjjm 1882 17 - - HYPH cord-023095-4dannjjm 1882 18 impact impact NN cord-023095-4dannjjm 1882 19 - - HYPH cord-023095-4dannjjm 1882 20 scores score NNS cord-023095-4dannjjm 1882 21 ( ( -LRB- cord-023095-4dannjjm 1882 22 AWIS AWIS NNP cord-023095-4dannjjm 1882 23 ; ; : cord-023095-4dannjjm 1882 24 average average JJ cord-023095-4dannjjm 1882 25 IWIS IWIS NNP cord-023095-4dannjjm 1882 26 of of IN cord-023095-4dannjjm 1882 27 all all DT cord-023095-4dannjjm 1882 28 items item NNS cord-023095-4dannjjm 1882 29 ) ) -RRB- cord-023095-4dannjjm 1882 30 , , , cord-023095-4dannjjm 1882 31 as as IN cord-023095-4dannjjm 1882 32 an an DT cord-023095-4dannjjm 1882 33 overall overall JJ cord-023095-4dannjjm 1882 34 measure measure NN cord-023095-4dannjjm 1882 35 of of IN cord-023095-4dannjjm 1882 36 diabetes diabetes NN cord-023095-4dannjjm 1882 37 dependent dependent JJ cord-023095-4dannjjm 1882 38 QoL. QoL. NNP cord-023095-4dannjjm 1882 39 Frequencies Frequencies NNPS cord-023095-4dannjjm 1882 40 , , , cord-023095-4dannjjm 1882 41 IWIS IWIS NNP cord-023095-4dannjjm 1882 42 and and CC cord-023095-4dannjjm 1882 43 AWIS AWIS NNP cord-023095-4dannjjm 1882 44 were be VBD cord-023095-4dannjjm 1882 45 compared compare VBN cord-023095-4dannjjm 1882 46 between between IN cord-023095-4dannjjm 1882 47 owners owner NNS cord-023095-4dannjjm 1882 48 practising practise VBG cord-023095-4dannjjm 1882 49 HBGM HBGM NNS cord-023095-4dannjjm 1882 50 and and CC cord-023095-4dannjjm 1882 51 those those DT cord-023095-4dannjjm 1882 52 who who WP cord-023095-4dannjjm 1882 53 did do VBD cord-023095-4dannjjm 1882 54 not not RB cord-023095-4dannjjm 1882 55 using use VBG cord-023095-4dannjjm 1882 56 Mann Mann NNP cord-023095-4dannjjm 1882 57 Whitney Whitney NNP cord-023095-4dannjjm 1882 58 U U NNP cord-023095-4dannjjm 1882 59 test test NN cord-023095-4dannjjm 1882 60 ( ( -LRB- cord-023095-4dannjjm 1882 61 significance significance NN cord-023095-4dannjjm 1882 62 p p NN cord-023095-4dannjjm 1882 63 o o NN cord-023095-4dannjjm 1882 64 0.05 0.05 CD cord-023095-4dannjjm 1882 65 ) ) -RRB- cord-023095-4dannjjm 1882 66 . . . cord-023095-4dannjjm 1883 1 Two two CD cord-023095-4dannjjm 1883 2 hundred hundred CD cord-023095-4dannjjm 1883 3 and and CC cord-023095-4dannjjm 1883 4 eleven eleven CD cord-023095-4dannjjm 1883 5 owners owner NNS cord-023095-4dannjjm 1883 6 of of IN cord-023095-4dannjjm 1883 7 insulin insulin NN cord-023095-4dannjjm 1883 8 treated treat VBN cord-023095-4dannjjm 1883 9 diabetic diabetic JJ cord-023095-4dannjjm 1883 10 cats cat NNS cord-023095-4dannjjm 1883 11 completed complete VBD cord-023095-4dannjjm 1883 12 the the DT cord-023095-4dannjjm 1883 13 DIAQoL diaqol NN cord-023095-4dannjjm 1883 14 - - HYPH cord-023095-4dannjjm 1883 15 pet pet NN cord-023095-4dannjjm 1883 16 ; ; : cord-023095-4dannjjm 1883 17 161 161 CD cord-023095-4dannjjm 1883 18 owners owner NNS cord-023095-4dannjjm 1883 19 practised practise VBD cord-023095-4dannjjm 1883 20 HBGM HBGM NNS cord-023095-4dannjjm 1883 21 , , , cord-023095-4dannjjm 1883 22 whereas whereas IN cord-023095-4dannjjm 1883 23 the the DT cord-023095-4dannjjm 1883 24 remaining remain VBG cord-023095-4dannjjm 1883 25 50 50 CD cord-023095-4dannjjm 1883 26 did do VBD cord-023095-4dannjjm 1883 27 not not RB cord-023095-4dannjjm 1883 28 practise practise VB cord-023095-4dannjjm 1883 29 any any DT cord-023095-4dannjjm 1883 30 form form NN cord-023095-4dannjjm 1883 31 of of IN cord-023095-4dannjjm 1883 32 home home NN cord-023095-4dannjjm 1883 33 monitoring monitoring NN cord-023095-4dannjjm 1883 34 ( ( -LRB- cord-023095-4dannjjm 1883 35 including include VBG cord-023095-4dannjjm 1883 36 urine urine NN cord-023095-4dannjjm 1883 37 glucose glucose NN cord-023095-4dannjjm 1883 38 ) ) -RRB- cord-023095-4dannjjm 1883 39 . . . cord-023095-4dannjjm 1884 1 IWIS IWIS NNP cord-023095-4dannjjm 1884 2 for for IN cord-023095-4dannjjm 1884 3 ' ' `` cord-023095-4dannjjm 1884 4 excessive excessive JJ cord-023095-4dannjjm 1884 5 drinking drinking NN cord-023095-4dannjjm 1884 6 ' ' '' cord-023095-4dannjjm 1884 7 and and CC cord-023095-4dannjjm 1885 1 ' ' POS cord-023095-4dannjjm 1885 2 owner owner NN cord-023095-4dannjjm 1885 3 wanting want VBG cord-023095-4dannjjm 1885 4 more more JJR cord-023095-4dannjjm 1885 5 control control NN cord-023095-4dannjjm 1885 6 ' ' '' cord-023095-4dannjjm 1885 7 were be VBD cord-023095-4dannjjm 1885 8 significantly significantly RB cord-023095-4dannjjm 1885 9 different different JJ cord-023095-4dannjjm 1885 10 between between IN cord-023095-4dannjjm 1885 11 the the DT cord-023095-4dannjjm 1885 12 HBGM HBGM NNP cord-023095-4dannjjm 1885 13 - - HYPH cord-023095-4dannjjm 1885 14 group group NN cord-023095-4dannjjm 1885 15 ( ( -LRB- cord-023095-4dannjjm 1885 16 mean1/-standard mean1/-standard NNP cord-023095-4dannjjm 1885 17 deviation deviation NN cord-023095-4dannjjm 1885 18 : : : cord-023095-4dannjjm 1885 19 À2.011 à2.011 CD cord-023095-4dannjjm 1885 20 / / SYM cord-023095-4dannjjm 1885 21 À2.4 À2.4 NNP cord-023095-4dannjjm 1885 22 and and CC cord-023095-4dannjjm 1885 23 À5.071 à5.071 CD cord-023095-4dannjjm 1885 24 / / SYM cord-023095-4dannjjm 1885 25 À4.8 À4.8 NNP cord-023095-4dannjjm 1885 26 ) ) -RRB- cord-023095-4dannjjm 1885 27 and and CC cord-023095-4dannjjm 1885 28 the the DT cord-023095-4dannjjm 1885 29 non non JJ cord-023095-4dannjjm 1885 30 - - JJ cord-023095-4dannjjm 1885 31 HBGM hbgm JJ cord-023095-4dannjjm 1885 32 - - HYPH cord-023095-4dannjjm 1885 33 group group NN cord-023095-4dannjjm 1886 1 ( ( -LRB- cord-023095-4dannjjm 1886 2 À3.361 À3.361 VBG cord-023095-4dannjjm 1886 3 / / SYM cord-023095-4dannjjm 1886 4 À3.8 À3.8 NNP cord-023095-4dannjjm 1886 5 and and CC cord-023095-4dannjjm 1886 6 À1.861 à1.861 CD cord-023095-4dannjjm 1886 7 / / SYM cord-023095-4dannjjm 1886 8 À3.2 À3.2 NNP cord-023095-4dannjjm 1886 9 ) ) -RRB- cord-023095-4dannjjm 1886 10 . . . cord-023095-4dannjjm 1887 1 There there EX cord-023095-4dannjjm 1887 2 was be VBD cord-023095-4dannjjm 1887 3 no no DT cord-023095-4dannjjm 1887 4 significant significant JJ cord-023095-4dannjjm 1887 5 difference difference NN cord-023095-4dannjjm 1887 6 between between IN cord-023095-4dannjjm 1887 7 the the DT cord-023095-4dannjjm 1887 8 groups group NNS cord-023095-4dannjjm 1887 9 with with IN cord-023095-4dannjjm 1887 10 regards regard NNS cord-023095-4dannjjm 1887 11 to to IN cord-023095-4dannjjm 1887 12 the the DT cord-023095-4dannjjm 1887 13 IWIS IWIS NNP cord-023095-4dannjjm 1887 14 for for IN cord-023095-4dannjjm 1887 15 other other JJ cord-023095-4dannjjm 1887 16 items item NNS cord-023095-4dannjjm 1887 17 , , , cord-023095-4dannjjm 1887 18 including include VBG cord-023095-4dannjjm 1887 19 ' ' '' cord-023095-4dannjjm 1887 20 worry worry NN cord-023095-4dannjjm 1887 21 about about IN cord-023095-4dannjjm 1887 22 hypoglycaemia hypoglycaemia NN cord-023095-4dannjjm 1887 23 ' ' '' cord-023095-4dannjjm 1887 24 or or CC cord-023095-4dannjjm 1887 25 ' ' '' cord-023095-4dannjjm 1887 26 worry worry NN cord-023095-4dannjjm 1887 27 about about IN cord-023095-4dannjjm 1887 28 pet pet NN cord-023095-4dannjjm 1887 29 's 's POS cord-023095-4dannjjm 1887 30 DM dm NN cord-023095-4dannjjm 1887 31 ' ' '' cord-023095-4dannjjm 1887 32 . . . cord-023095-4dannjjm 1888 1 Polydipsia Polydipsia NNP cord-023095-4dannjjm 1888 2 was be VBD cord-023095-4dannjjm 1888 3 reported report VBN cord-023095-4dannjjm 1888 4 significantly significantly RB cord-023095-4dannjjm 1888 5 more more RBR cord-023095-4dannjjm 1888 6 frequently frequently RB cord-023095-4dannjjm 1888 7 in in IN cord-023095-4dannjjm 1888 8 the the DT cord-023095-4dannjjm 1888 9 non non JJ cord-023095-4dannjjm 1888 10 - - JJ cord-023095-4dannjjm 1888 11 HBGM hbgm JJ cord-023095-4dannjjm 1888 12 - - HYPH cord-023095-4dannjjm 1888 13 group group NN cord-023095-4dannjjm 1888 14 and and CC cord-023095-4dannjjm 1888 15 this this DT cord-023095-4dannjjm 1888 16 was be VBD cord-023095-4dannjjm 1888 17 the the DT cord-023095-4dannjjm 1888 18 reason reason NN cord-023095-4dannjjm 1888 19 for for IN cord-023095-4dannjjm 1888 20 the the DT cord-023095-4dannjjm 1888 21 difference difference NN cord-023095-4dannjjm 1888 22 between between IN cord-023095-4dannjjm 1888 23 groups group NNS cord-023095-4dannjjm 1888 24 in in IN cord-023095-4dannjjm 1888 25 this this DT cord-023095-4dannjjm 1888 26 item item NN cord-023095-4dannjjm 1888 27 's 's POS cord-023095-4dannjjm 1888 28 IWIS IWIS NNP cord-023095-4dannjjm 1888 29 as as IN cord-023095-4dannjjm 1888 30 it -PRON- PRP cord-023095-4dannjjm 1888 31 was be VBD cord-023095-4dannjjm 1888 32 considered consider VBN cord-023095-4dannjjm 1888 33 of of IN cord-023095-4dannjjm 1888 34 equal equal JJ cord-023095-4dannjjm 1888 35 importance importance NN cord-023095-4dannjjm 1888 36 . . . cord-023095-4dannjjm 1889 1 Frequency frequency NN cord-023095-4dannjjm 1889 2 and and CC cord-023095-4dannjjm 1889 3 IWIS IWIS NNP cord-023095-4dannjjm 1889 4 of of IN cord-023095-4dannjjm 1889 5 reported report VBN cord-023095-4dannjjm 1889 6 occurrence occurrence NN cord-023095-4dannjjm 1889 7 of of IN cord-023095-4dannjjm 1889 8 hypoglycaemia hypoglycaemia NN cord-023095-4dannjjm 1889 9 signs sign NNS cord-023095-4dannjjm 1889 10 were be VBD cord-023095-4dannjjm 1889 11 not not RB cord-023095-4dannjjm 1889 12 significantly significantly RB cord-023095-4dannjjm 1889 13 different different JJ cord-023095-4dannjjm 1889 14 . . . cord-023095-4dannjjm 1890 1 AWIS AWIS NNP cord-023095-4dannjjm 1890 2 for for IN cord-023095-4dannjjm 1890 3 both both DT cord-023095-4dannjjm 1890 4 groups group NNS cord-023095-4dannjjm 1890 5 was be VBD cord-023095-4dannjjm 1890 6 not not RB cord-023095-4dannjjm 1890 7 significantly significantly RB cord-023095-4dannjjm 1890 8 different different JJ cord-023095-4dannjjm 1891 1 ( ( -LRB- cord-023095-4dannjjm 1891 2 HBGM HBGM NNP cord-023095-4dannjjm 1891 3 : : : cord-023095-4dannjjm 1892 1 À1.851 À1.851 NNP cord-023095-4dannjjm 1892 2 / / SYM cord-023095-4dannjjm 1892 3 À1.3 à1.3 XX cord-023095-4dannjjm 1892 4 ; ; : cord-023095-4dannjjm 1892 5 non non JJ cord-023095-4dannjjm 1892 6 - - JJ cord-023095-4dannjjm 1892 7 HBGM hbgm JJ cord-023095-4dannjjm 1892 8 : : : cord-023095-4dannjjm 1892 9 À1.871 à1.871 CD cord-023095-4dannjjm 1892 10 / / SYM cord-023095-4dannjjm 1892 11 À1.1 à1.1 CD cord-023095-4dannjjm 1892 12 ) ) -RRB- cord-023095-4dannjjm 1892 13 . . . cord-023095-4dannjjm 1893 1 The the DT cord-023095-4dannjjm 1893 2 current current JJ cord-023095-4dannjjm 1893 3 study study NN cord-023095-4dannjjm 1893 4 suggests suggest VBZ cord-023095-4dannjjm 1893 5 that that IN cord-023095-4dannjjm 1893 6 HBGM HBGM NNP cord-023095-4dannjjm 1893 7 is be VBZ cord-023095-4dannjjm 1893 8 predominantly predominantly RB cord-023095-4dannjjm 1893 9 practised practise VBN cord-023095-4dannjjm 1893 10 by by IN cord-023095-4dannjjm 1893 11 owners owner NNS cord-023095-4dannjjm 1893 12 who who WP cord-023095-4dannjjm 1893 13 desire desire VBP cord-023095-4dannjjm 1893 14 more more RBR cord-023095-4dannjjm 1893 15 autonomous autonomous JJ cord-023095-4dannjjm 1893 16 control control NN cord-023095-4dannjjm 1893 17 over over IN cord-023095-4dannjjm 1893 18 their -PRON- PRP$ cord-023095-4dannjjm 1893 19 cat cat NN cord-023095-4dannjjm 1893 20 's 's POS cord-023095-4dannjjm 1893 21 DM dm NN cord-023095-4dannjjm 1893 22 . . . cord-023095-4dannjjm 1894 1 The the DT cord-023095-4dannjjm 1894 2 frequency frequency NN cord-023095-4dannjjm 1894 3 of of IN cord-023095-4dannjjm 1894 4 polydipsia polydipsia NN cord-023095-4dannjjm 1894 5 was be VBD cord-023095-4dannjjm 1894 6 lower low JJR cord-023095-4dannjjm 1894 7 in in IN cord-023095-4dannjjm 1894 8 the the DT cord-023095-4dannjjm 1894 9 HBGM HBGM NNP cord-023095-4dannjjm 1894 10 - - HYPH cord-023095-4dannjjm 1894 11 group group NN cord-023095-4dannjjm 1894 12 perhaps perhaps RB cord-023095-4dannjjm 1894 13 suggesting suggest VBG cord-023095-4dannjjm 1894 14 superior superior JJ cord-023095-4dannjjm 1894 15 control control NN cord-023095-4dannjjm 1894 16 . . . cord-023095-4dannjjm 1895 1 However however RB cord-023095-4dannjjm 1895 2 , , , cord-023095-4dannjjm 1895 3 HBGM HBGM NNP cord-023095-4dannjjm 1895 4 did do VBD cord-023095-4dannjjm 1895 5 not not RB cord-023095-4dannjjm 1895 6 detectably detectably RB cord-023095-4dannjjm 1895 7 affect affect VB cord-023095-4dannjjm 1895 8 the the DT cord-023095-4dannjjm 1895 9 impact impact NN cord-023095-4dannjjm 1895 10 of of IN cord-023095-4dannjjm 1895 11 the the DT cord-023095-4dannjjm 1895 12 majority majority NN cord-023095-4dannjjm 1895 13 of of IN cord-023095-4dannjjm 1895 14 QoL qol NN cord-023095-4dannjjm 1895 15 - - HYPH cord-023095-4dannjjm 1895 16 items item NNS cord-023095-4dannjjm 1895 17 , , , cord-023095-4dannjjm 1895 18 nor nor CC cord-023095-4dannjjm 1895 19 the the DT cord-023095-4dannjjm 1895 20 frequency frequency NN cord-023095-4dannjjm 1895 21 of of IN cord-023095-4dannjjm 1895 22 hypoglycaemic hypoglycaemic JJ cord-023095-4dannjjm 1895 23 episodes episode NNS cord-023095-4dannjjm 1895 24 . . . cord-023095-4dannjjm 1896 1 Overall overall JJ cord-023095-4dannjjm 1896 2 diabetes diabetes NN cord-023095-4dannjjm 1896 3 dependent dependent JJ cord-023095-4dannjjm 1896 4 QoL qol NN cord-023095-4dannjjm 1896 5 of of IN cord-023095-4dannjjm 1896 6 diabetic diabetic JJ cord-023095-4dannjjm 1896 7 cat cat NN cord-023095-4dannjjm 1896 8 and and CC cord-023095-4dannjjm 1896 9 owner owner NN cord-023095-4dannjjm 1896 10 , , , cord-023095-4dannjjm 1896 11 as as IN cord-023095-4dannjjm 1896 12 measured measure VBN cord-023095-4dannjjm 1896 13 per per IN cord-023095-4dannjjm 1896 14 DIAQoL diaqol NN cord-023095-4dannjjm 1896 15 - - HYPH cord-023095-4dannjjm 1896 16 pet pet NN cord-023095-4dannjjm 1896 17 , , , cord-023095-4dannjjm 1896 18 was be VBD cord-023095-4dannjjm 1896 19 unaffected unaffected JJ cord-023095-4dannjjm 1896 20 by by IN cord-023095-4dannjjm 1896 21 HBGM HBGM NNS cord-023095-4dannjjm 1896 22 . . . cord-023095-4dannjjm 1897 1 These these DT cord-023095-4dannjjm 1897 2 data datum NNS cord-023095-4dannjjm 1897 3 argue argue VBP cord-023095-4dannjjm 1897 4 for for IN cord-023095-4dannjjm 1897 5 the the DT cord-023095-4dannjjm 1897 6 use use NN cord-023095-4dannjjm 1897 7 of of IN cord-023095-4dannjjm 1897 8 HBGM HBGM NNP cord-023095-4dannjjm 1897 9 in in IN cord-023095-4dannjjm 1897 10 selected select VBN cord-023095-4dannjjm 1897 11 pet pet JJ cord-023095-4dannjjm 1897 12 - - HYPH cord-023095-4dannjjm 1897 13 owner owner NN cord-023095-4dannjjm 1897 14 combinations combination NNS cord-023095-4dannjjm 1897 15 rather rather RB cord-023095-4dannjjm 1897 16 than than IN cord-023095-4dannjjm 1897 17 as as IN cord-023095-4dannjjm 1897 18 part part NN cord-023095-4dannjjm 1897 19 of of IN cord-023095-4dannjjm 1897 20 a a DT cord-023095-4dannjjm 1897 21 practice practice NN cord-023095-4dannjjm 1897 22 's 's POS cord-023095-4dannjjm 1897 23 standard standard JJ cord-023095-4dannjjm 1897 24 DM dm NN cord-023095-4dannjjm 1897 25 management management NN cord-023095-4dannjjm 1897 26 protocol protocol NN cord-023095-4dannjjm 1897 27 , , , cord-023095-4dannjjm 1897 28 although although IN cord-023095-4dannjjm 1897 29 further further JJ cord-023095-4dannjjm 1897 30 studies study NNS cord-023095-4dannjjm 1897 31 are be VBP cord-023095-4dannjjm 1897 32 indicated indicate VBN cord-023095-4dannjjm 1897 33 . . . cord-023095-4dannjjm 1898 1 Insulin insulin NN cord-023095-4dannjjm 1898 2 resistance resistance NN cord-023095-4dannjjm 1898 3 is be VBZ cord-023095-4dannjjm 1898 4 associated associate VBN cord-023095-4dannjjm 1898 5 with with IN cord-023095-4dannjjm 1898 6 impaired impaired JJ cord-023095-4dannjjm 1898 7 activation activation NN cord-023095-4dannjjm 1898 8 of of IN cord-023095-4dannjjm 1898 9 the the DT cord-023095-4dannjjm 1898 10 insulin insulin NN cord-023095-4dannjjm 1898 11 signaling signal VBG cord-023095-4dannjjm 1898 12 pathway pathway NN cord-023095-4dannjjm 1898 13 in in IN cord-023095-4dannjjm 1898 14 peripheral peripheral JJ cord-023095-4dannjjm 1898 15 tissues tissue NNS cord-023095-4dannjjm 1898 16 such such JJ cord-023095-4dannjjm 1898 17 as as IN cord-023095-4dannjjm 1898 18 skeletal skeletal JJ cord-023095-4dannjjm 1898 19 muscle muscle NN cord-023095-4dannjjm 1898 20 , , , cord-023095-4dannjjm 1898 21 visceral visceral JJ cord-023095-4dannjjm 1898 22 and and CC cord-023095-4dannjjm 1898 23 subcutaneous subcutaneous JJ cord-023095-4dannjjm 1898 24 ( ( -LRB- cord-023095-4dannjjm 1898 25 SC SC NNP cord-023095-4dannjjm 1898 26 ) ) -RRB- cord-023095-4dannjjm 1898 27 adipose adipose JJ cord-023095-4dannjjm 1898 28 tissue tissue NN cord-023095-4dannjjm 1898 29 . . . cord-023095-4dannjjm 1899 1 High high JJ cord-023095-4dannjjm 1899 2 plasma plasma NN cord-023095-4dannjjm 1899 3 glucose glucose NN cord-023095-4dannjjm 1899 4 , , , cord-023095-4dannjjm 1899 5 fatty fatty JJ cord-023095-4dannjjm 1899 6 acid acid NN cord-023095-4dannjjm 1899 7 and and CC cord-023095-4dannjjm 1899 8 endotoxin endotoxin NN cord-023095-4dannjjm 1899 9 levels level NNS cord-023095-4dannjjm 1899 10 are be VBP cord-023095-4dannjjm 1899 11 three three CD cord-023095-4dannjjm 1899 12 major major JJ cord-023095-4dannjjm 1899 13 causes cause NNS cord-023095-4dannjjm 1899 14 of of IN cord-023095-4dannjjm 1899 15 insulin insulin NN cord-023095-4dannjjm 1899 16 resistance resistance NN cord-023095-4dannjjm 1899 17 in in IN cord-023095-4dannjjm 1899 18 feline feline JJ cord-023095-4dannjjm 1899 19 and and CC cord-023095-4dannjjm 1899 20 human human JJ cord-023095-4dannjjm 1899 21 obesity obesity NN cord-023095-4dannjjm 1899 22 and and CC cord-023095-4dannjjm 1899 23 in in IN cord-023095-4dannjjm 1899 24 type type NN cord-023095-4dannjjm 1899 25 2 2 CD cord-023095-4dannjjm 1899 26 diabetes diabetes NN cord-023095-4dannjjm 1899 27 mellitus mellitus NN cord-023095-4dannjjm 1899 28 . . . cord-023095-4dannjjm 1900 1 However however RB cord-023095-4dannjjm 1900 2 , , , cord-023095-4dannjjm 1900 3 the the DT cord-023095-4dannjjm 1900 4 mechanisms mechanism NNS cord-023095-4dannjjm 1900 5 by by IN cord-023095-4dannjjm 1900 6 which which WDT cord-023095-4dannjjm 1900 7 these these DT cord-023095-4dannjjm 1900 8 factors factor NNS cord-023095-4dannjjm 1900 9 influence influence VBP cord-023095-4dannjjm 1900 10 insulin insulin NN cord-023095-4dannjjm 1900 11 action action NN cord-023095-4dannjjm 1900 12 are be VBP cord-023095-4dannjjm 1900 13 still still RB cord-023095-4dannjjm 1900 14 unclear unclear JJ cord-023095-4dannjjm 1900 15 . . . cord-023095-4dannjjm 1901 1 Therefore therefore RB cord-023095-4dannjjm 1901 2 , , , cord-023095-4dannjjm 1901 3 our -PRON- PRP$ cord-023095-4dannjjm 1901 4 aim aim NN cord-023095-4dannjjm 1901 5 was be VBD cord-023095-4dannjjm 1901 6 to to TO cord-023095-4dannjjm 1901 7 investigate investigate VB cord-023095-4dannjjm 1901 8 the the DT cord-023095-4dannjjm 1901 9 tissue tissue NN cord-023095-4dannjjm 1901 10 - - HYPH cord-023095-4dannjjm 1901 11 specific specific JJ cord-023095-4dannjjm 1901 12 expression expression NN cord-023095-4dannjjm 1901 13 of of IN cord-023095-4dannjjm 1901 14 crucial crucial JJ cord-023095-4dannjjm 1901 15 mediators mediator NNS cord-023095-4dannjjm 1901 16 of of IN cord-023095-4dannjjm 1901 17 insulin insulin NN cord-023095-4dannjjm 1901 18 action action NN cord-023095-4dannjjm 1901 19 such such JJ cord-023095-4dannjjm 1901 20 as as IN cord-023095-4dannjjm 1901 21 the the DT cord-023095-4dannjjm 1901 22 insulin insulin NN cord-023095-4dannjjm 1901 23 - - HYPH cord-023095-4dannjjm 1901 24 receptor receptor NN cord-023095-4dannjjm 1901 25 substrate substrate NN cord-023095-4dannjjm 1901 26 1 1 CD cord-023095-4dannjjm 1901 27 ( ( -LRB- cord-023095-4dannjjm 1901 28 IRS1 IRS1 NNP cord-023095-4dannjjm 1901 29 ) ) -RRB- cord-023095-4dannjjm 1902 1 , , , cord-023095-4dannjjm 1902 2 the the DT cord-023095-4dannjjm 1902 3 serine serine NN cord-023095-4dannjjm 1902 4 / / SYM cord-023095-4dannjjm 1902 5 threonine threonine NN cord-023095-4dannjjm 1902 6 protein protein NN cord-023095-4dannjjm 1902 7 kinase kinase NN cord-023095-4dannjjm 1902 8 B B NNP cord-023095-4dannjjm 1902 9 ( ( -LRB- cord-023095-4dannjjm 1902 10 PKB PKB NNP cord-023095-4dannjjm 1902 11 / / SYM cord-023095-4dannjjm 1902 12 Akt Akt NNP cord-023095-4dannjjm 1902 13 ) ) -RRB- cord-023095-4dannjjm 1902 14 and and CC cord-023095-4dannjjm 1903 1 of of IN cord-023095-4dannjjm 1903 2 the the DT cord-023095-4dannjjm 1903 3 principal principal JJ cord-023095-4dannjjm 1903 4 insulin insulin NN cord-023095-4dannjjm 1903 5 - - HYPH cord-023095-4dannjjm 1903 6 dependent dependent JJ cord-023095-4dannjjm 1903 7 glucose glucose NN cord-023095-4dannjjm 1903 8 transporter transporter NN cord-023095-4dannjjm 1903 9 protein protein NN cord-023095-4dannjjm 1903 10 ( ( -LRB- cord-023095-4dannjjm 1903 11 GLUT4 GLUT4 NNP cord-023095-4dannjjm 1903 12 ) ) -RRB- cord-023095-4dannjjm 1903 13 in in IN cord-023095-4dannjjm 1903 14 feline feline JJ cord-023095-4dannjjm 1903 15 models model NNS cord-023095-4dannjjm 1903 16 of of IN cord-023095-4dannjjm 1903 17 hyperglycemia hyperglycemia NN cord-023095-4dannjjm 1903 18 , , , cord-023095-4dannjjm 1903 19 hyperlipidemia hyperlipidemia NN cord-023095-4dannjjm 1903 20 and and CC cord-023095-4dannjjm 1903 21 subacute subacute JJ cord-023095-4dannjjm 1903 22 endotoxemia endotoxemia NN cord-023095-4dannjjm 1903 23 . . . cord-023095-4dannjjm 1904 1 Healthy healthy JJ cord-023095-4dannjjm 1904 2 cats cat NNS cord-023095-4dannjjm 1904 3 were be VBD cord-023095-4dannjjm 1904 4 infused infuse VBN cord-023095-4dannjjm 1904 5 through through IN cord-023095-4dannjjm 1904 6 the the DT cord-023095-4dannjjm 1904 7 jugular jugular NN cord-023095-4dannjjm 1904 8 vein vein NN cord-023095-4dannjjm 1904 9 with with IN cord-023095-4dannjjm 1904 10 glucose glucose NN cord-023095-4dannjjm 1904 11 ( ( -LRB- cord-023095-4dannjjm 1904 12 n n NN cord-023095-4dannjjm 1904 13 5 5 CD cord-023095-4dannjjm 1904 14 5 5 CD cord-023095-4dannjjm 1904 15 ) ) -RRB- cord-023095-4dannjjm 1904 16 , , , cord-023095-4dannjjm 1904 17 lipids lipid NNS cord-023095-4dannjjm 1904 18 ( ( -LRB- cord-023095-4dannjjm 1904 19 n n NN cord-023095-4dannjjm 1904 20 5 5 CD cord-023095-4dannjjm 1904 21 6 6 CD cord-023095-4dannjjm 1904 22 ) ) -RRB- cord-023095-4dannjjm 1904 23 or or CC cord-023095-4dannjjm 1904 24 lipopolysaccharide lipopolysaccharide NN cord-023095-4dannjjm 1904 25 ( ( -LRB- cord-023095-4dannjjm 1904 26 LPS LPS NNP cord-023095-4dannjjm 1904 27 ; ; : cord-023095-4dannjjm 1904 28 n n NN cord-023095-4dannjjm 1904 29 5 5 CD cord-023095-4dannjjm 1904 30 5 5 CD cord-023095-4dannjjm 1904 31 ) ) -RRB- cord-023095-4dannjjm 1904 32 for for IN cord-023095-4dannjjm 1904 33 10 10 CD cord-023095-4dannjjm 1904 34 days day NNS cord-023095-4dannjjm 1904 35 to to TO cord-023095-4dannjjm 1904 36 clamp clamp VB cord-023095-4dannjjm 1904 37 their -PRON- PRP$ cord-023095-4dannjjm 1904 38 blood blood NN cord-023095-4dannjjm 1904 39 concentrations concentration NNS cord-023095-4dannjjm 1904 40 at at IN cord-023095-4dannjjm 1904 41 the the DT cord-023095-4dannjjm 1904 42 approximate approximate JJ cord-023095-4dannjjm 1904 43 level level NN cord-023095-4dannjjm 1904 44 found find VBN cord-023095-4dannjjm 1904 45 in in IN cord-023095-4dannjjm 1904 46 untreated untreated JJ cord-023095-4dannjjm 1904 47 feline feline JJ cord-023095-4dannjjm 1904 48 diabetes diabetes NN cord-023095-4dannjjm 1904 49 ( ( -LRB- cord-023095-4dannjjm 1904 50 glucose glucose NN cord-023095-4dannjjm 1904 51 : : : cord-023095-4dannjjm 1904 52 25 25 CD cord-023095-4dannjjm 1904 53 - - SYM cord-023095-4dannjjm 1904 54 30 30 CD cord-023095-4dannjjm 1904 55 mmol mmol NN cord-023095-4dannjjm 1904 56 / / SYM cord-023095-4dannjjm 1904 57 l l NN cord-023095-4dannjjm 1904 58 ; ; : cord-023095-4dannjjm 1904 59 triglycerides triglyceride NNS cord-023095-4dannjjm 1904 60 : : : cord-023095-4dannjjm 1904 61 3 3 CD cord-023095-4dannjjm 1904 62 - - SYM cord-023095-4dannjjm 1904 63 7 7 CD cord-023095-4dannjjm 1904 64 mmol mmol NN cord-023095-4dannjjm 1904 65 / / SYM cord-023095-4dannjjm 1904 66 l l NN cord-023095-4dannjjm 1904 67 ) ) -RRB- cord-023095-4dannjjm 1904 68 or or CC cord-023095-4dannjjm 1904 69 to to TO cord-023095-4dannjjm 1904 70 induce induce VB cord-023095-4dannjjm 1904 71 a a DT cord-023095-4dannjjm 1904 72 systemic systemic JJ cord-023095-4dannjjm 1904 73 low low JJ cord-023095-4dannjjm 1904 74 - - HYPH cord-023095-4dannjjm 1904 75 grade grade NN cord-023095-4dannjjm 1904 76 inflammation inflammation NN cord-023095-4dannjjm 1904 77 ( ( -LRB- cord-023095-4dannjjm 1904 78 LPS lp NNS cord-023095-4dannjjm 1904 79 ; ; : cord-023095-4dannjjm 1904 80 rectal rectal JJ cord-023095-4dannjjm 1904 81 temperature temperature NN cord-023095-4dannjjm 1904 82 : : : cord-023095-4dannjjm 1904 83 39.2 39.2 CD cord-023095-4dannjjm 1904 84 - - HYPH cord-023095-4dannjjm 1904 85 40.51C 40.51c CD cord-023095-4dannjjm 1904 86 ) ) -RRB- cord-023095-4dannjjm 1904 87 , , , cord-023095-4dannjjm 1904 88 respectively respectively RB cord-023095-4dannjjm 1904 89 . . . cord-023095-4dannjjm 1905 1 Healthy healthy JJ cord-023095-4dannjjm 1905 2 control control NN cord-023095-4dannjjm 1905 3 cats cat NNS cord-023095-4dannjjm 1905 4 were be VBD cord-023095-4dannjjm 1905 5 infused infuse VBN cord-023095-4dannjjm 1905 6 with with IN cord-023095-4dannjjm 1905 7 saline saline NN cord-023095-4dannjjm 1905 8 ( ( -LRB- cord-023095-4dannjjm 1905 9 n n NN cord-023095-4dannjjm 1905 10 5 5 CD cord-023095-4dannjjm 1905 11 10 10 CD cord-023095-4dannjjm 1905 12 ) ) -RRB- cord-023095-4dannjjm 1905 13 . . . cord-023095-4dannjjm 1906 1 On on IN cord-023095-4dannjjm 1906 2 day day NN cord-023095-4dannjjm 1906 3 10 10 CD cord-023095-4dannjjm 1906 4 , , , cord-023095-4dannjjm 1906 5 specimens specimen NNS cord-023095-4dannjjm 1906 6 were be VBD cord-023095-4dannjjm 1906 7 collected collect VBN cord-023095-4dannjjm 1906 8 from from IN cord-023095-4dannjjm 1906 9 skeletal skeletal JJ cord-023095-4dannjjm 1906 10 muscles muscle NNS cord-023095-4dannjjm 1906 11 , , , cord-023095-4dannjjm 1906 12 visceral visceral JJ cord-023095-4dannjjm 1906 13 and and CC cord-023095-4dannjjm 1906 14 SC SC NNP cord-023095-4dannjjm 1906 15 fat fat NN cord-023095-4dannjjm 1906 16 and and CC cord-023095-4dannjjm 1906 17 processed process VBN cord-023095-4dannjjm 1906 18 for for IN cord-023095-4dannjjm 1907 1 IRS1 IRS1 NNP cord-023095-4dannjjm 1907 2 mRNA mRNA NNP cord-023095-4dannjjm 1907 3 expression expression NN cord-023095-4dannjjm 1907 4 , , , cord-023095-4dannjjm 1907 5 total total JJ cord-023095-4dannjjm 1907 6 and and CC cord-023095-4dannjjm 1907 7 phosphorylated phosphorylated JJ cord-023095-4dannjjm 1907 8 PKB PKB NNP cord-023095-4dannjjm 1907 9 / / SYM cord-023095-4dannjjm 1907 10 Akt Akt NNP cord-023095-4dannjjm 1907 11 and and CC cord-023095-4dannjjm 1907 12 GLUT4 GLUT4 NNP cord-023095-4dannjjm 1907 13 protein protein NN cord-023095-4dannjjm 1907 14 expression expression NN cord-023095-4dannjjm 1907 15 . . . cord-023095-4dannjjm 1908 1 Gene gene NN cord-023095-4dannjjm 1908 2 transcripts transcript NNS cord-023095-4dannjjm 1908 3 of of IN cord-023095-4dannjjm 1908 4 IRS1 IRS1 NNP cord-023095-4dannjjm 1908 5 were be VBD cord-023095-4dannjjm 1908 6 not not RB cord-023095-4dannjjm 1908 7 different different JJ cord-023095-4dannjjm 1908 8 between between IN cord-023095-4dannjjm 1908 9 the the DT cord-023095-4dannjjm 1908 10 groups group NNS cord-023095-4dannjjm 1908 11 . . . cord-023095-4dannjjm 1909 1 Compared compare VBN cord-023095-4dannjjm 1909 2 to to IN cord-023095-4dannjjm 1909 3 controls control NNS cord-023095-4dannjjm 1909 4 , , , cord-023095-4dannjjm 1909 5 skeletal skeletal JJ cord-023095-4dannjjm 1909 6 muscle muscle NN cord-023095-4dannjjm 1909 7 PKB PKB NNP cord-023095-4dannjjm 1909 8 / / SYM cord-023095-4dannjjm 1909 9 Akt Akt NNP cord-023095-4dannjjm 1909 10 phosphorylation phosphorylation NN cord-023095-4dannjjm 1909 11 was be VBD cord-023095-4dannjjm 1909 12 91 91 CD cord-023095-4dannjjm 1909 13 % % NN cord-023095-4dannjjm 1909 14 lower low JJR cord-023095-4dannjjm 1909 15 in in IN cord-023095-4dannjjm 1909 16 cats cat NNS cord-023095-4dannjjm 1909 17 infused infuse VBN cord-023095-4dannjjm 1909 18 with with IN cord-023095-4dannjjm 1909 19 glucose glucose NN cord-023095-4dannjjm 1909 20 ( ( -LRB- cord-023095-4dannjjm 1909 21 P p NN cord-023095-4dannjjm 1909 22 o o NN cord-023095-4dannjjm 1909 23 0.01 0.01 CD cord-023095-4dannjjm 1909 24 ) ) -RRB- cord-023095-4dannjjm 1909 25 ; ; : cord-023095-4dannjjm 1909 26 lipid lipid NN cord-023095-4dannjjm 1909 27 - - HYPH cord-023095-4dannjjm 1909 28 infused infuse VBN cord-023095-4dannjjm 1909 29 cats cat NNS cord-023095-4dannjjm 1909 30 showed show VBD cord-023095-4dannjjm 1909 31 a a DT cord-023095-4dannjjm 1909 32 trend trend NN cord-023095-4dannjjm 1909 33 for for IN cord-023095-4dannjjm 1909 34 a a DT cord-023095-4dannjjm 1909 35 decrease decrease NN cord-023095-4dannjjm 1909 36 in in IN cord-023095-4dannjjm 1909 37 PKB PKB NNP cord-023095-4dannjjm 1909 38 / / SYM cord-023095-4dannjjm 1909 39 Akt Akt NNP cord-023095-4dannjjm 1909 40 phosphorylation phosphorylation NN cord-023095-4dannjjm 1909 41 ( ( -LRB- cord-023095-4dannjjm 1909 42 31 31 CD cord-023095-4dannjjm 1909 43 % % NN cord-023095-4dannjjm 1909 44 lower low JJR cord-023095-4dannjjm 1909 45 than than IN cord-023095-4dannjjm 1909 46 saline saline NN cord-023095-4dannjjm 1909 47 ) ) -RRB- cord-023095-4dannjjm 1909 48 and and CC cord-023095-4dannjjm 1909 49 had have VBD cord-023095-4dannjjm 1909 50 decreased decrease VBN cord-023095-4dannjjm 1909 51 GLUT4 glut4 JJ cord-023095-4dannjjm 1909 52 expression expression NN cord-023095-4dannjjm 1909 53 ( ( -LRB- cord-023095-4dannjjm 1909 54 P p NN cord-023095-4dannjjm 1909 55 o o NN cord-023095-4dannjjm 1909 56 0.05 0.05 CD cord-023095-4dannjjm 1909 57 ) ) -RRB- cord-023095-4dannjjm 1909 58 in in IN cord-023095-4dannjjm 1909 59 muscle muscle NN cord-023095-4dannjjm 1909 60 . . . cord-023095-4dannjjm 1910 1 Total total JJ cord-023095-4dannjjm 1910 2 ( ( -LRB- cord-023095-4dannjjm 1910 3 p p NN cord-023095-4dannjjm 1910 4 o o NN cord-023095-4dannjjm 1910 5 0.01 0.01 CD cord-023095-4dannjjm 1910 6 ) ) -RRB- cord-023095-4dannjjm 1910 7 and and CC cord-023095-4dannjjm 1910 8 phosphorylated phosphorylate VBN cord-023095-4dannjjm 1910 9 ( ( -LRB- cord-023095-4dannjjm 1910 10 P p NN cord-023095-4dannjjm 1910 11 o o NN cord-023095-4dannjjm 1910 12 0.05 0.05 CD cord-023095-4dannjjm 1910 13 ) ) -RRB- cord-023095-4dannjjm 1911 1 PKB PKB NNP cord-023095-4dannjjm 1911 2 / / SYM cord-023095-4dannjjm 1911 3 Akt Akt NNP cord-023095-4dannjjm 1911 4 protein protein NN cord-023095-4dannjjm 1911 5 expression expression NN cord-023095-4dannjjm 1911 6 were be VBD cord-023095-4dannjjm 1911 7 decreased decrease VBN cord-023095-4dannjjm 1911 8 in in IN cord-023095-4dannjjm 1911 9 the the DT cord-023095-4dannjjm 1911 10 SC SC NNP cord-023095-4dannjjm 1911 11 adipose adipose JJ cord-023095-4dannjjm 1911 12 tissue tissue NN cord-023095-4dannjjm 1911 13 of of IN cord-023095-4dannjjm 1911 14 LPS LPS NNP cord-023095-4dannjjm 1911 15 - - HYPH cord-023095-4dannjjm 1911 16 infused infuse VBN cord-023095-4dannjjm 1911 17 cats cat NNS cord-023095-4dannjjm 1911 18 compared compare VBN cord-023095-4dannjjm 1911 19 to to IN cord-023095-4dannjjm 1911 20 controls control NNS cord-023095-4dannjjm 1911 21 . . . cord-023095-4dannjjm 1912 1 In in IN cord-023095-4dannjjm 1912 2 these these DT cord-023095-4dannjjm 1912 3 cats cat NNS cord-023095-4dannjjm 1912 4 , , , cord-023095-4dannjjm 1912 5 phosphorylation phosphorylation NN cord-023095-4dannjjm 1912 6 of of IN cord-023095-4dannjjm 1912 7 PKB PKB NNP cord-023095-4dannjjm 1912 8 / / SYM cord-023095-4dannjjm 1912 9 Akt Akt NNP cord-023095-4dannjjm 1912 10 protein protein NN cord-023095-4dannjjm 1912 11 was be VBD cord-023095-4dannjjm 1912 12 also also RB cord-023095-4dannjjm 1912 13 decreased decrease VBN cord-023095-4dannjjm 1912 14 in in IN cord-023095-4dannjjm 1912 15 visceral visceral JJ cord-023095-4dannjjm 1912 16 fat fat NN cord-023095-4dannjjm 1912 17 ( ( -LRB- cord-023095-4dannjjm 1912 18 p p NN cord-023095-4dannjjm 1912 19 o o NN cord-023095-4dannjjm 1912 20 0.01 0.01 CD cord-023095-4dannjjm 1912 21 ) ) -RRB- cord-023095-4dannjjm 1912 22 . . . cord-023095-4dannjjm 1913 1 Sustained sustained JJ cord-023095-4dannjjm 1913 2 hyperglycemia hyperglycemia NN cord-023095-4dannjjm 1913 3 and and CC cord-023095-4dannjjm 1913 4 , , , cord-023095-4dannjjm 1913 5 to to IN cord-023095-4dannjjm 1913 6 a a DT cord-023095-4dannjjm 1913 7 lesser less JJR cord-023095-4dannjjm 1913 8 extent extent NN cord-023095-4dannjjm 1913 9 , , , cord-023095-4dannjjm 1913 10 hyperlipidemia hyperlipidemia NN cord-023095-4dannjjm 1913 11 impaired impair VBD cord-023095-4dannjjm 1913 12 insulin insulin NN cord-023095-4dannjjm 1913 13 signaling signaling NN cord-023095-4dannjjm 1913 14 and and CC cord-023095-4dannjjm 1913 15 glucose glucose NN cord-023095-4dannjjm 1913 16 transport transport NN cord-023095-4dannjjm 1913 17 pathways pathway NNS cord-023095-4dannjjm 1913 18 primarily primarily RB cord-023095-4dannjjm 1913 19 in in IN cord-023095-4dannjjm 1913 20 skeletal skeletal JJ cord-023095-4dannjjm 1913 21 muscle muscle NN cord-023095-4dannjjm 1913 22 ; ; : cord-023095-4dannjjm 1913 23 endotoxemia endotoxemia NN cord-023095-4dannjjm 1913 24 reduced reduce VBD cord-023095-4dannjjm 1913 25 insulin insulin NN cord-023095-4dannjjm 1913 26 sensitivity sensitivity NN cord-023095-4dannjjm 1913 27 mainly mainly RB cord-023095-4dannjjm 1913 28 in in IN cord-023095-4dannjjm 1913 29 adipose adipose JJ cord-023095-4dannjjm 1913 30 tissues tissue NNS cord-023095-4dannjjm 1913 31 . . . cord-023095-4dannjjm 1914 1 Thus thus RB cord-023095-4dannjjm 1914 2 , , , cord-023095-4dannjjm 1914 3 the the DT cord-023095-4dannjjm 1914 4 development development NN cord-023095-4dannjjm 1914 5 of of IN cord-023095-4dannjjm 1914 6 insulin insulin NN cord-023095-4dannjjm 1914 7 resistance resistance NN cord-023095-4dannjjm 1914 8 in in IN cord-023095-4dannjjm 1914 9 response response NN cord-023095-4dannjjm 1914 10 to to IN cord-023095-4dannjjm 1914 11 hyperglycemia hyperglycemia NN cord-023095-4dannjjm 1914 12 , , , cord-023095-4dannjjm 1914 13 hyperlipidemia hyperlipidemia NN cord-023095-4dannjjm 1914 14 or or CC cord-023095-4dannjjm 1914 15 endotoxemia endotoxemia NN cord-023095-4dannjjm 1914 16 might may MD cord-023095-4dannjjm 1914 17 be be VB cord-023095-4dannjjm 1914 18 affected affect VBN cord-023095-4dannjjm 1914 19 by by IN cord-023095-4dannjjm 1914 20 tissue tissue NN cord-023095-4dannjjm 1914 21 - - HYPH cord-023095-4dannjjm 1914 22 specific specific JJ cord-023095-4dannjjm 1914 23 mechanisms mechanism NNS cord-023095-4dannjjm 1914 24 in in IN cord-023095-4dannjjm 1914 25 cats cat NNS cord-023095-4dannjjm 1914 26 . . . cord-023095-4dannjjm 1915 1 Separately separately RB cord-023095-4dannjjm 1915 2 used use VBN cord-023095-4dannjjm 1915 3 , , , cord-023095-4dannjjm 1915 4 Single Single NNP cord-023095-4dannjjm 1915 5 Photon Photon NNP cord-023095-4dannjjm 1915 6 Emission Emission NNP cord-023095-4dannjjm 1915 7 Computed compute VBN cord-023095-4dannjjm 1915 8 Tomography Tomography NNP cord-023095-4dannjjm 1915 9 ( ( -LRB- cord-023095-4dannjjm 1915 10 SPECT SPECT NNP cord-023095-4dannjjm 1915 11 ) ) -RRB- cord-023095-4dannjjm 1915 12 and and CC cord-023095-4dannjjm 1915 13 Computed compute VBN cord-023095-4dannjjm 1915 14 Tomography Tomography NNP cord-023095-4dannjjm 1915 15 ( ( -LRB- cord-023095-4dannjjm 1915 16 CT CT NNP cord-023095-4dannjjm 1915 17 ) ) -RRB- cord-023095-4dannjjm 1915 18 both both DT cord-023095-4dannjjm 1915 19 lack lack VBP cord-023095-4dannjjm 1915 20 sensitivity sensitivity NN cord-023095-4dannjjm 1915 21 and and CC cord-023095-4dannjjm 1915 22 are be VBP cord-023095-4dannjjm 1915 23 additionally additionally RB cord-023095-4dannjjm 1915 24 hampered hamper VBN cord-023095-4dannjjm 1915 25 by by IN cord-023095-4dannjjm 1915 26 a a DT cord-023095-4dannjjm 1915 27 poor poor JJ cord-023095-4dannjjm 1915 28 anatomical anatomical JJ cord-023095-4dannjjm 1915 29 location location NN cord-023095-4dannjjm 1915 30 capacity capacity NN cord-023095-4dannjjm 1915 31 and and CC cord-023095-4dannjjm 1915 32 a a DT cord-023095-4dannjjm 1915 33 lack lack NN cord-023095-4dannjjm 1915 34 of of IN cord-023095-4dannjjm 1915 35 specificity specificity NN cord-023095-4dannjjm 1915 36 , , , cord-023095-4dannjjm 1915 37 respectively respectively RB cord-023095-4dannjjm 1915 38 . . . cord-023095-4dannjjm 1916 1 These these DT cord-023095-4dannjjm 1916 2 drawbacks drawback NNS cord-023095-4dannjjm 1916 3 suggest suggest VBP cord-023095-4dannjjm 1916 4 an an DT cord-023095-4dannjjm 1916 5 interest interest NN cord-023095-4dannjjm 1916 6 in in IN cord-023095-4dannjjm 1916 7 the the DT cord-023095-4dannjjm 1916 8 fusion fusion NN cord-023095-4dannjjm 1916 9 of of IN cord-023095-4dannjjm 1916 10 images image NNS cord-023095-4dannjjm 1916 11 obtained obtain VBN cord-023095-4dannjjm 1916 12 by by IN cord-023095-4dannjjm 1916 13 the the DT cord-023095-4dannjjm 1916 14 2 2 CD cord-023095-4dannjjm 1916 15 techniques technique NNS cord-023095-4dannjjm 1916 16 . . . cord-023095-4dannjjm 1917 1 The the DT cord-023095-4dannjjm 1917 2 aim aim NN cord-023095-4dannjjm 1917 3 of of IN cord-023095-4dannjjm 1917 4 this this DT cord-023095-4dannjjm 1917 5 study study NN cord-023095-4dannjjm 1917 6 is be VBZ cord-023095-4dannjjm 1917 7 to to TO cord-023095-4dannjjm 1917 8 test test VB cord-023095-4dannjjm 1917 9 SPECT SPECT NNP cord-023095-4dannjjm 1917 10 / / SYM cord-023095-4dannjjm 1917 11 CT CT NNP cord-023095-4dannjjm 1917 12 fusion fusion NN cord-023095-4dannjjm 1917 13 performance performance NN cord-023095-4dannjjm 1917 14 in in IN cord-023095-4dannjjm 1917 15 dogs dog NNS cord-023095-4dannjjm 1917 16 with with IN cord-023095-4dannjjm 1917 17 insulinoma insulinoma NN cord-023095-4dannjjm 1917 18 . . . cord-023095-4dannjjm 1918 1 Inclusion inclusion NN cord-023095-4dannjjm 1918 2 criteria criterion NNS cord-023095-4dannjjm 1918 3 were be VBD cord-023095-4dannjjm 1918 4 : : : cord-023095-4dannjjm 1918 5 1/ 1/ CD cord-023095-4dannjjm 1918 6 a a DT cord-023095-4dannjjm 1918 7 biological biological JJ cord-023095-4dannjjm 1918 8 diagnosis diagnosis NN cord-023095-4dannjjm 1918 9 of of IN cord-023095-4dannjjm 1918 10 insulinoma insulinoma NN cord-023095-4dannjjm 1918 11 ; ; : cord-023095-4dannjjm 1918 12 2/ 2/ CD cord-023095-4dannjjm 1918 13 an an DT cord-023095-4dannjjm 1918 14 examination examination NN cord-023095-4dannjjm 1918 15 by by IN cord-023095-4dannjjm 1918 16 high high JJ cord-023095-4dannjjm 1918 17 resolution resolution NN cord-023095-4dannjjm 1918 18 CT CT NNP cord-023095-4dannjjm 1918 19 scan scan NN cord-023095-4dannjjm 1918 20 and and CC cord-023095-4dannjjm 1919 1 111 111 CD cord-023095-4dannjjm 1919 2 In in IN cord-023095-4dannjjm 1919 3 - - HYPH cord-023095-4dannjjm 1919 4 pentetreotide pentetreotide NN cord-023095-4dannjjm 1919 5 SPECT SPECT NNS cord-023095-4dannjjm 1919 6 followed follow VBN cord-023095-4dannjjm 1919 7 by by IN cord-023095-4dannjjm 1919 8 SPECT SPECT NNP cord-023095-4dannjjm 1919 9 / / SYM cord-023095-4dannjjm 1919 10 CT CT NNP cord-023095-4dannjjm 1919 11 fusion fusion NN cord-023095-4dannjjm 1919 12 ; ; : cord-023095-4dannjjm 1919 13 3/ 3/ CD cord-023095-4dannjjm 1919 14 a a DT cord-023095-4dannjjm 1919 15 surgical surgical JJ cord-023095-4dannjjm 1919 16 or or CC cord-023095-4dannjjm 1919 17 post post AFX cord-023095-4dannjjm 1919 18 mortem mortem NN cord-023095-4dannjjm 1919 19 examination examination NN cord-023095-4dannjjm 1919 20 completed complete VBN cord-023095-4dannjjm 1919 21 by by IN cord-023095-4dannjjm 1919 22 histopathological histopathological NNP cord-023095-4dannjjm 1919 23 analysis analysis NN cord-023095-4dannjjm 1919 24 . . . cord-023095-4dannjjm 1920 1 SPECT SPECT NNP cord-023095-4dannjjm 1920 2 examination examination NN cord-023095-4dannjjm 1920 3 showing show VBG cord-023095-4dannjjm 1920 4 abnormal abnormal JJ cord-023095-4dannjjm 1920 5 foci foci NN cord-023095-4dannjjm 1920 6 and and CC cord-023095-4dannjjm 1920 7 CT CT NNP cord-023095-4dannjjm 1920 8 scan scan NN cord-023095-4dannjjm 1920 9 showing show VBG cord-023095-4dannjjm 1920 10 pancreas pancreas NN cord-023095-4dannjjm 1920 11 , , , cord-023095-4dannjjm 1920 12 lymph lymph NN cord-023095-4dannjjm 1920 13 nodes node NNS cord-023095-4dannjjm 1920 14 ( ( -LRB- cord-023095-4dannjjm 1920 15 LN LN NNP cord-023095-4dannjjm 1920 16 ) ) -RRB- cord-023095-4dannjjm 1920 17 or or CC cord-023095-4dannjjm 1920 18 liver liver NN cord-023095-4dannjjm 1920 19 abnormalities abnormality NNS cord-023095-4dannjjm 1920 20 were be VBD cord-023095-4dannjjm 1920 21 considered consider VBN cord-023095-4dannjjm 1920 22 positive positive JJ cord-023095-4dannjjm 1920 23 . . . cord-023095-4dannjjm 1921 1 In in IN cord-023095-4dannjjm 1921 2 case case NN cord-023095-4dannjjm 1921 3 of of IN cord-023095-4dannjjm 1921 4 double double JJ cord-023095-4dannjjm 1921 5 positivity positivity NN cord-023095-4dannjjm 1921 6 , , , cord-023095-4dannjjm 1921 7 presence presence NN cord-023095-4dannjjm 1921 8 ( ( -LRB- cord-023095-4dannjjm 1921 9 IMP1 IMP1 NNP cord-023095-4dannjjm 1921 10 ) ) -RRB- cord-023095-4dannjjm 1921 11 or or CC cord-023095-4dannjjm 1921 12 absence absence NN cord-023095-4dannjjm 1921 13 ( ( -LRB- cord-023095-4dannjjm 1921 14 IMP- IMP- NNP cord-023095-4dannjjm 1921 15 ) ) -RRB- cord-023095-4dannjjm 1921 16 of of IN cord-023095-4dannjjm 1921 17 superimposition superimposition NN cord-023095-4dannjjm 1921 18 of of IN cord-023095-4dannjjm 1921 19 abnormal abnormal JJ cord-023095-4dannjjm 1921 20 images image NNS cord-023095-4dannjjm 1921 21 was be VBD cord-023095-4dannjjm 1921 22 noted note VBN cord-023095-4dannjjm 1921 23 . . . cord-023095-4dannjjm 1922 1 Ten ten CD cord-023095-4dannjjm 1922 2 dogs dog NNS cord-023095-4dannjjm 1922 3 were be VBD cord-023095-4dannjjm 1922 4 included include VBN cord-023095-4dannjjm 1922 5 . . . cord-023095-4dannjjm 1923 1 In in IN cord-023095-4dannjjm 1923 2 2/10 2/10 CD cord-023095-4dannjjm 1923 3 dogs dog NNS cord-023095-4dannjjm 1923 4 , , , cord-023095-4dannjjm 1923 5 superimposition superimposition NN cord-023095-4dannjjm 1923 6 of of IN cord-023095-4dannjjm 1923 7 abnormalities abnormality NNS cord-023095-4dannjjm 1923 8 could could MD cord-023095-4dannjjm 1923 9 n't not RB cord-023095-4dannjjm 1923 10 be be VB cord-023095-4dannjjm 1923 11 tested test VBN cord-023095-4dannjjm 1923 12 . . . cord-023095-4dannjjm 1924 1 CT CT NNP cord-023095-4dannjjm 1924 2 scan scan NN cord-023095-4dannjjm 1924 3 detected detect VBD cord-023095-4dannjjm 1924 4 3 3 CD cord-023095-4dannjjm 1924 5 abnormal abnormal JJ cord-023095-4dannjjm 1924 6 images image NNS cord-023095-4dannjjm 1924 7 [ [ -LRB- cord-023095-4dannjjm 1924 8 2 2 CD cord-023095-4dannjjm 1924 9 pancreatic pancreatic JJ cord-023095-4dannjjm 1924 10 nodules nodule NNS cord-023095-4dannjjm 1924 11 ( ( -LRB- cord-023095-4dannjjm 1924 12 PN PN NNP cord-023095-4dannjjm 1924 13 ) ) -RRB- cord-023095-4dannjjm 1924 14 , , , cord-023095-4dannjjm 1924 15 1 1 CD cord-023095-4dannjjm 1924 16 enlarged enlarge VBD cord-023095-4dannjjm 1924 17 LN LN NNP cord-023095-4dannjjm 1924 18 ( ( -LRB- cord-023095-4dannjjm 1924 19 ELN ELN NNP cord-023095-4dannjjm 1924 20 ) ) -RRB- cord-023095-4dannjjm 1924 21 ] ] -RRB- cord-023095-4dannjjm 1924 22 while while IN cord-023095-4dannjjm 1924 23 SPECT SPECT NNP cord-023095-4dannjjm 1924 24 failed fail VBD cord-023095-4dannjjm 1924 25 to to TO cord-023095-4dannjjm 1924 26 show show VB cord-023095-4dannjjm 1924 27 any any DT cord-023095-4dannjjm 1924 28 abnormal abnormal JJ cord-023095-4dannjjm 1924 29 uptake uptake NN cord-023095-4dannjjm 1924 30 . . . cord-023095-4dannjjm 1925 1 Both both DT cord-023095-4dannjjm 1925 2 dogs dog NNS cord-023095-4dannjjm 1925 3 became become VBD cord-023095-4dannjjm 1925 4 euglycemic euglycemic JJ cord-023095-4dannjjm 1925 5 after after IN cord-023095-4dannjjm 1925 6 removal removal NN cord-023095-4dannjjm 1925 7 of of IN cord-023095-4dannjjm 1925 8 PN PN NNP cord-023095-4dannjjm 1925 9 and and CC cord-023095-4dannjjm 1925 10 LN LN NNP cord-023095-4dannjjm 1925 11 designed design VBN cord-023095-4dannjjm 1925 12 by by IN cord-023095-4dannjjm 1925 13 CT CT NNP cord-023095-4dannjjm 1925 14 scan scan NN cord-023095-4dannjjm 1925 15 . . . cord-023095-4dannjjm 1926 1 In in IN cord-023095-4dannjjm 1926 2 6/ 6/ CD cord-023095-4dannjjm 1926 3 10 10 CD cord-023095-4dannjjm 1926 4 , , , cord-023095-4dannjjm 1926 5 all all DT cord-023095-4dannjjm 1926 6 abnormal abnormal JJ cord-023095-4dannjjm 1926 7 images image NNS cord-023095-4dannjjm 1926 8 were be VBD cord-023095-4dannjjm 1926 9 classified classify VBN cord-023095-4dannjjm 1926 10 as as IN cord-023095-4dannjjm 1926 11 IMP1 IMP1 NNP cord-023095-4dannjjm 1926 12 [ [ -LRB- cord-023095-4dannjjm 1926 13 6 6 CD cord-023095-4dannjjm 1926 14 PN PN NNP cord-023095-4dannjjm 1926 15 , , , cord-023095-4dannjjm 1926 16 1 1 CD cord-023095-4dannjjm 1926 17 ELN ELN NNP cord-023095-4dannjjm 1926 18 and and CC cord-023095-4dannjjm 1926 19 1 1 CD cord-023095-4dannjjm 1926 20 diffuse diffuse JJ cord-023095-4dannjjm 1926 21 hepatic hepatic JJ cord-023095-4dannjjm 1926 22 infiltration infiltration NN cord-023095-4dannjjm 1926 23 ( ( -LRB- cord-023095-4dannjjm 1926 24 DHI DHI NNP cord-023095-4dannjjm 1926 25 ) ) -RRB- cord-023095-4dannjjm 1926 26 ] ] -RRB- cord-023095-4dannjjm 1926 27 . . . cord-023095-4dannjjm 1927 1 Surgery surgery NN cord-023095-4dannjjm 1927 2 performed perform VBD cord-023095-4dannjjm 1927 3 on on IN cord-023095-4dannjjm 1927 4 5/6 5/6 CD cord-023095-4dannjjm 1927 5 resulted result VBD cord-023095-4dannjjm 1927 6 in in IN cord-023095-4dannjjm 1927 7 euglycemia euglycemia NN cord-023095-4dannjjm 1927 8 in in IN cord-023095-4dannjjm 1927 9 4 4 CD cord-023095-4dannjjm 1927 10 ; ; SYM cord-023095-4dannjjm 1927 11 1 1 CD cord-023095-4dannjjm 1927 12 dog dog NN cord-023095-4dannjjm 1927 13 remained remain VBD cord-023095-4dannjjm 1927 14 hypoglycemic hypoglycemic JJ cord-023095-4dannjjm 1927 15 after after IN cord-023095-4dannjjm 1927 16 partial partial JJ cord-023095-4dannjjm 1927 17 removal removal NN cord-023095-4dannjjm 1927 18 of of IN cord-023095-4dannjjm 1927 19 1 1 CD cord-023095-4dannjjm 1927 20 PN pn NN cord-023095-4dannjjm 1927 21 . . . cord-023095-4dannjjm 1928 1 PN PN NNP cord-023095-4dannjjm 1928 2 localization localization NN cord-023095-4dannjjm 1928 3 and and CC cord-023095-4dannjjm 1928 4 DHI DHI NNP cord-023095-4dannjjm 1928 5 were be VBD cord-023095-4dannjjm 1928 6 confirmed confirm VBN cord-023095-4dannjjm 1928 7 after after IN cord-023095-4dannjjm 1928 8 necropsy necropsy JJ cord-023095-4dannjjm 1928 9 in in IN cord-023095-4dannjjm 1928 10 the the DT cord-023095-4dannjjm 1928 11 6 6 CD cord-023095-4dannjjm 1928 12 th th XX cord-023095-4dannjjm 1928 13 dog dog NN cord-023095-4dannjjm 1928 14 . . . cord-023095-4dannjjm 1929 1 In in IN cord-023095-4dannjjm 1929 2 2/10 2/10 CD cord-023095-4dannjjm 1929 3 dogs dog NNS cord-023095-4dannjjm 1929 4 IMP1 IMP1 NNP cord-023095-4dannjjm 1929 5 and and CC cord-023095-4dannjjm 1929 6 IMP IMP NNP cord-023095-4dannjjm 1929 7 - - HYPH cord-023095-4dannjjm 1929 8 images image NNS cord-023095-4dannjjm 1929 9 were be VBD cord-023095-4dannjjm 1929 10 both both DT cord-023095-4dannjjm 1929 11 recorded record VBN cord-023095-4dannjjm 1929 12 . . . cord-023095-4dannjjm 1930 1 In in IN cord-023095-4dannjjm 1930 2 1 1 CD cord-023095-4dannjjm 1930 3 dog dog NN cord-023095-4dannjjm 1930 4 , , , cord-023095-4dannjjm 1930 5 a a DT cord-023095-4dannjjm 1930 6 DHI DHI NNP cord-023095-4dannjjm 1930 7 was be VBD cord-023095-4dannjjm 1930 8 classified classify VBN cord-023095-4dannjjm 1930 9 as as IN cord-023095-4dannjjm 1930 10 IMP1 IMP1 NNP cord-023095-4dannjjm 1930 11 but but CC cord-023095-4dannjjm 1930 12 PN PN NNP cord-023095-4dannjjm 1930 13 localization localization NN cord-023095-4dannjjm 1930 14 was be VBD cord-023095-4dannjjm 1930 15 IMP- IMP- NNP cord-023095-4dannjjm 1930 16 : : : cord-023095-4dannjjm 1930 17 localized localize VBN cord-023095-4dannjjm 1930 18 in in IN cord-023095-4dannjjm 1930 19 the the DT cord-023095-4dannjjm 1930 20 left left JJ cord-023095-4dannjjm 1930 21 lobe lobe NN cord-023095-4dannjjm 1930 22 by by IN cord-023095-4dannjjm 1930 23 CT CT NNP cord-023095-4dannjjm 1930 24 scan scan NNP cord-023095-4dannjjm 1930 25 and and CC cord-023095-4dannjjm 1930 26 in in IN cord-023095-4dannjjm 1930 27 the the DT cord-023095-4dannjjm 1930 28 corpus corpus NN cord-023095-4dannjjm 1930 29 by by IN cord-023095-4dannjjm 1930 30 SPECT SPECT NNP cord-023095-4dannjjm 1930 31 , , , cord-023095-4dannjjm 1930 32 the the DT cord-023095-4dannjjm 1930 33 latest late JJS cord-023095-4dannjjm 1930 34 localization localization NN cord-023095-4dannjjm 1930 35 being be VBG cord-023095-4dannjjm 1930 36 confirmed confirm VBN cord-023095-4dannjjm 1930 37 after after IN cord-023095-4dannjjm 1930 38 necropsy necropsy JJ cord-023095-4dannjjm 1930 39 . . . cord-023095-4dannjjm 1931 1 In in IN cord-023095-4dannjjm 1931 2 the the DT cord-023095-4dannjjm 1931 3 other other JJ cord-023095-4dannjjm 1931 4 dog dog NN cord-023095-4dannjjm 1931 5 PN pn NN cord-023095-4dannjjm 1931 6 localization localization NN cord-023095-4dannjjm 1931 7 was be VBD cord-023095-4dannjjm 1931 8 IMP1 IMP1 NNP cord-023095-4dannjjm 1931 9 but but CC cord-023095-4dannjjm 1931 10 a a DT cord-023095-4dannjjm 1931 11 diffuse diffuse JJ cord-023095-4dannjjm 1931 12 SPECT spect NN cord-023095-4dannjjm 1931 13 signal signal NN cord-023095-4dannjjm 1931 14 superimposing superimposing NN cord-023095-4dannjjm 1931 15 to to IN cord-023095-4dannjjm 1931 16 the the DT cord-023095-4dannjjm 1931 17 liver liver NN cord-023095-4dannjjm 1931 18 considered consider VBN cord-023095-4dannjjm 1931 19 as as RB cord-023095-4dannjjm 1931 20 normal normal JJ cord-023095-4dannjjm 1931 21 on on IN cord-023095-4dannjjm 1931 22 CT CT NNP cord-023095-4dannjjm 1931 23 scan scan NNP cord-023095-4dannjjm 1931 24 was be VBD cord-023095-4dannjjm 1931 25 noted note VBN cord-023095-4dannjjm 1931 26 . . . cord-023095-4dannjjm 1932 1 Hepatic hepatic JJ cord-023095-4dannjjm 1932 2 biopsy biopsy NN cord-023095-4dannjjm 1932 3 confirmed confirm VBD cord-023095-4dannjjm 1932 4 SPECT SPECT NNP cord-023095-4dannjjm 1932 5 results result NNS cord-023095-4dannjjm 1932 6 . . . cord-023095-4dannjjm 1933 1 This this DT cord-023095-4dannjjm 1933 2 study study NN cord-023095-4dannjjm 1933 3 confirms confirm VBZ cord-023095-4dannjjm 1933 4 an an DT cord-023095-4dannjjm 1933 5 imperfect imperfect JJ cord-023095-4dannjjm 1933 6 sensitivity sensitivity NN cord-023095-4dannjjm 1933 7 of of IN cord-023095-4dannjjm 1933 8 both both DT cord-023095-4dannjjm 1933 9 CT CT NNP cord-023095-4dannjjm 1933 10 scan scan NN cord-023095-4dannjjm 1933 11 and and CC cord-023095-4dannjjm 1933 12 SPECT SPECT NNS cord-023095-4dannjjm 1933 13 . . . cord-023095-4dannjjm 1934 1 It -PRON- PRP cord-023095-4dannjjm 1934 2 confirms confirm VBZ cord-023095-4dannjjm 1934 3 that that IN cord-023095-4dannjjm 1934 4 CT CT NNP cord-023095-4dannjjm 1934 5 scan scan NN cord-023095-4dannjjm 1934 6 can can MD cord-023095-4dannjjm 1934 7 be be VB cord-023095-4dannjjm 1934 8 associated associate VBN cord-023095-4dannjjm 1934 9 with with IN cord-023095-4dannjjm 1934 10 unspecific unspecific JJ cord-023095-4dannjjm 1934 11 abnormal abnormal JJ cord-023095-4dannjjm 1934 12 images image NNS cord-023095-4dannjjm 1934 13 . . . cord-023095-4dannjjm 1935 1 Subject subject JJ cord-023095-4dannjjm 1935 2 to to IN cord-023095-4dannjjm 1935 3 a a DT cord-023095-4dannjjm 1935 4 confirmation confirmation NN cord-023095-4dannjjm 1935 5 on on IN cord-023095-4dannjjm 1935 6 a a DT cord-023095-4dannjjm 1935 7 larger large JJR cord-023095-4dannjjm 1935 8 cohort cohort NN cord-023095-4dannjjm 1935 9 of of IN cord-023095-4dannjjm 1935 10 dogs dog NNS cord-023095-4dannjjm 1935 11 , , , cord-023095-4dannjjm 1935 12 it -PRON- PRP cord-023095-4dannjjm 1935 13 indicates indicate VBZ cord-023095-4dannjjm 1935 14 that that IN cord-023095-4dannjjm 1935 15 IMP1 IMP1 NNP cord-023095-4dannjjm 1935 16 images image NNS cord-023095-4dannjjm 1935 17 provide provide VB cord-023095-4dannjjm 1935 18 specific specific JJ cord-023095-4dannjjm 1935 19 detection detection NN cord-023095-4dannjjm 1935 20 and and CC cord-023095-4dannjjm 1935 21 accurate accurate JJ cord-023095-4dannjjm 1935 22 localization localization NN cord-023095-4dannjjm 1935 23 of of IN cord-023095-4dannjjm 1935 24 canine canine JJ cord-023095-4dannjjm 1935 25 insulinomas insulinomas NNP cord-023095-4dannjjm 1935 26 ' ' POS cord-023095-4dannjjm 1935 27 primary primary JJ cord-023095-4dannjjm 1935 28 lesions lesion NNS cord-023095-4dannjjm 1935 29 and and CC cord-023095-4dannjjm 1935 30 metastasis metastasis NN cord-023095-4dannjjm 1935 31 . . . cord-023095-4dannjjm 1936 1 The the DT cord-023095-4dannjjm 1936 2 majority majority NN cord-023095-4dannjjm 1936 3 of of IN cord-023095-4dannjjm 1936 4 dogs dog NNS cord-023095-4dannjjm 1936 5 with with IN cord-023095-4dannjjm 1936 6 primary primary JJ cord-023095-4dannjjm 1936 7 hypoadrenocorticism hypoadrenocorticism NN cord-023095-4dannjjm 1936 8 ( ( -LRB- cord-023095-4dannjjm 1936 9 PH PH NNP cord-023095-4dannjjm 1936 10 ) ) -RRB- cord-023095-4dannjjm 1936 11 reveal reveal VB cord-023095-4dannjjm 1936 12 clinical clinical JJ cord-023095-4dannjjm 1936 13 and and CC cord-023095-4dannjjm 1936 14 laboratory laboratory NN cord-023095-4dannjjm 1936 15 abnormalities abnormality NNS cord-023095-4dannjjm 1936 16 of of IN cord-023095-4dannjjm 1936 17 gluco gluco NNP cord-023095-4dannjjm 1936 18 - - HYPH cord-023095-4dannjjm 1936 19 and and CC cord-023095-4dannjjm 1936 20 mineralocorticoid mineralocorticoid NN cord-023095-4dannjjm 1936 21 deficiency deficiency NN cord-023095-4dannjjm 1936 22 . . . cord-023095-4dannjjm 1937 1 In in IN cord-023095-4dannjjm 1937 2 some some DT cord-023095-4dannjjm 1937 3 of of IN cord-023095-4dannjjm 1937 4 them -PRON- PRP cord-023095-4dannjjm 1937 5 sodium sodium NN cord-023095-4dannjjm 1937 6 and and CC cord-023095-4dannjjm 1937 7 potassium potassium NN cord-023095-4dannjjm 1937 8 levels level NNS cord-023095-4dannjjm 1937 9 are be VBP cord-023095-4dannjjm 1937 10 normal normal JJ cord-023095-4dannjjm 1937 11 , , , cord-023095-4dannjjm 1937 12 a a DT cord-023095-4dannjjm 1937 13 phenomenon phenomenon NN cord-023095-4dannjjm 1937 14 currently currently RB cord-023095-4dannjjm 1937 15 called call VBN cord-023095-4dannjjm 1937 16 atypical atypical JJ cord-023095-4dannjjm 1937 17 Addison Addison NNP cord-023095-4dannjjm 1937 18 's 's POS cord-023095-4dannjjm 1937 19 . . . cord-023095-4dannjjm 1938 1 It -PRON- PRP cord-023095-4dannjjm 1938 2 has have VBZ cord-023095-4dannjjm 1938 3 been be VBN cord-023095-4dannjjm 1938 4 postulated postulate VBN cord-023095-4dannjjm 1938 5 that that IN cord-023095-4dannjjm 1938 6 in in IN cord-023095-4dannjjm 1938 7 those those DT cord-023095-4dannjjm 1938 8 cases case NNS cord-023095-4dannjjm 1938 9 adrenal adrenal JJ cord-023095-4dannjjm 1938 10 destruction destruction NN cord-023095-4dannjjm 1938 11 is be VBZ cord-023095-4dannjjm 1938 12 confined confine VBN cord-023095-4dannjjm 1938 13 to to IN cord-023095-4dannjjm 1938 14 the the DT cord-023095-4dannjjm 1938 15 zona zona NNP cord-023095-4dannjjm 1938 16 fasciculata fasciculata NNP cord-023095-4dannjjm 1938 17 / / SYM cord-023095-4dannjjm 1938 18 reticularis reticularis NNPS cord-023095-4dannjjm 1938 19 , , , cord-023095-4dannjjm 1938 20 resulting result VBG cord-023095-4dannjjm 1938 21 in in IN cord-023095-4dannjjm 1938 22 isolated isolate VBN cord-023095-4dannjjm 1938 23 glucocorticoid glucocorticoid NN cord-023095-4dannjjm 1938 24 deficiency deficiency NN cord-023095-4dannjjm 1938 25 . . . cord-023095-4dannjjm 1939 1 However however RB cord-023095-4dannjjm 1939 2 , , , cord-023095-4dannjjm 1939 3 there there EX cord-023095-4dannjjm 1939 4 are be VBP cord-023095-4dannjjm 1939 5 no no DT cord-023095-4dannjjm 1939 6 histological histological JJ cord-023095-4dannjjm 1939 7 studies study NNS cord-023095-4dannjjm 1939 8 confirming confirm VBG cord-023095-4dannjjm 1939 9 a a DT cord-023095-4dannjjm 1939 10 normal normal JJ cord-023095-4dannjjm 1939 11 zona zona NNP cord-023095-4dannjjm 1939 12 glomerulosa glomerulosa JJ cord-023095-4dannjjm 1939 13 and and CC cord-023095-4dannjjm 1939 14 in in IN cord-023095-4dannjjm 1939 15 most most RBS cord-023095-4dannjjm 1939 16 reported report VBN cord-023095-4dannjjm 1939 17 cases case NNS cord-023095-4dannjjm 1939 18 diagnosis diagnosis NN cord-023095-4dannjjm 1939 19 was be VBD cord-023095-4dannjjm 1939 20 based base VBN cord-023095-4dannjjm 1939 21 solely solely RB cord-023095-4dannjjm 1939 22 on on IN cord-023095-4dannjjm 1939 23 low low JJ cord-023095-4dannjjm 1939 24 post post JJ cord-023095-4dannjjm 1939 25 - - JJ cord-023095-4dannjjm 1939 26 ACTH acth JJ cord-023095-4dannjjm 1939 27 cortisol cortisol NN cord-023095-4dannjjm 1939 28 levels level NNS cord-023095-4dannjjm 1939 29 . . . cord-023095-4dannjjm 1940 1 The the DT cord-023095-4dannjjm 1940 2 aim aim NN cord-023095-4dannjjm 1940 3 of of IN cord-023095-4dannjjm 1940 4 the the DT cord-023095-4dannjjm 1940 5 study study NN cord-023095-4dannjjm 1940 6 was be VBD cord-023095-4dannjjm 1940 7 to to TO cord-023095-4dannjjm 1940 8 evaluate evaluate VB cord-023095-4dannjjm 1940 9 aldosterone aldosterone NN cord-023095-4dannjjm 1940 10 ( ( -LRB- cord-023095-4dannjjm 1940 11 ALDO ALDO NNP cord-023095-4dannjjm 1940 12 ) ) -RRB- cord-023095-4dannjjm 1940 13 levels level NNS cord-023095-4dannjjm 1940 14 in in IN cord-023095-4dannjjm 1940 15 dogs dog NNS cord-023095-4dannjjm 1940 16 with with IN cord-023095-4dannjjm 1940 17 PH PH NNP cord-023095-4dannjjm 1940 18 with with IN cord-023095-4dannjjm 1940 19 and and CC cord-023095-4dannjjm 1940 20 without without IN cord-023095-4dannjjm 1940 21 electrolyte electrolyte JJ cord-023095-4dannjjm 1940 22 abnormalities abnormality NNS cord-023095-4dannjjm 1940 23 . . . cord-023095-4dannjjm 1941 1 Seventy seventy CD cord-023095-4dannjjm 1941 2 dogs dog NNS cord-023095-4dannjjm 1941 3 with with IN cord-023095-4dannjjm 1941 4 newly newly RB cord-023095-4dannjjm 1941 5 diagnosed diagnose VBN cord-023095-4dannjjm 1941 6 PH PH NNP cord-023095-4dannjjm 1941 7 were be VBD cord-023095-4dannjjm 1941 8 included include VBN cord-023095-4dannjjm 1941 9 . . . cord-023095-4dannjjm 1942 1 ALDO ALDO NNP cord-023095-4dannjjm 1942 2 concentrations concentration NNS cord-023095-4dannjjm 1942 3 ( ( -LRB- cord-023095-4dannjjm 1942 4 RIA RIA NNP cord-023095-4dannjjm 1942 5 , , , cord-023095-4dannjjm 1942 6 Coat Coat NNP cord-023095-4dannjjm 1942 7 - - HYPH cord-023095-4dannjjm 1942 8 A A NNP cord-023095-4dannjjm 1942 9 - - HYPH cord-023095-4dannjjm 1942 10 Count Count NNP cord-023095-4dannjjm 1942 11 s s NNP cord-023095-4dannjjm 1942 12 , , , cord-023095-4dannjjm 1942 13 Siemens Siemens NNP cord-023095-4dannjjm 1942 14 ) ) -RRB- cord-023095-4dannjjm 1942 15 were be VBD cord-023095-4dannjjm 1942 16 measured measure VBN cord-023095-4dannjjm 1942 17 before before RB cord-023095-4dannjjm 1942 18 and and CC cord-023095-4dannjjm 1942 19 60 60 CD cord-023095-4dannjjm 1942 20 min min NN cord-023095-4dannjjm 1942 21 after after IN cord-023095-4dannjjm 1942 22 administration administration NN cord-023095-4dannjjm 1942 23 of of IN cord-023095-4dannjjm 1942 24 250 250 CD cord-023095-4dannjjm 1942 25 mg mg CD cord-023095-4dannjjm 1942 26 synthetic synthetic JJ cord-023095-4dannjjm 1942 27 ACTH ACTH NNP cord-023095-4dannjjm 1943 1 ( ( -LRB- cord-023095-4dannjjm 1943 2 Synacthen Synacthen NNP cord-023095-4dannjjm 1943 3 s s NNP cord-023095-4dannjjm 1943 4 , , , cord-023095-4dannjjm 1943 5 Novartis Novartis NNP cord-023095-4dannjjm 1943 6 ) ) -RRB- cord-023095-4dannjjm 1943 7 IV IV NNP cord-023095-4dannjjm 1943 8 . . . cord-023095-4dannjjm 1944 1 Results result NNS cord-023095-4dannjjm 1944 2 were be VBD cord-023095-4dannjjm 1944 3 compared compare VBN cord-023095-4dannjjm 1944 4 to to IN cord-023095-4dannjjm 1944 5 those those DT cord-023095-4dannjjm 1944 6 of of IN cord-023095-4dannjjm 1944 7 19 19 CD cord-023095-4dannjjm 1944 8 healthy healthy JJ cord-023095-4dannjjm 1944 9 dogs dog NNS cord-023095-4dannjjm 1944 10 and and CC cord-023095-4dannjjm 1944 11 17 17 CD cord-023095-4dannjjm 1944 12 dogs dog NNS cord-023095-4dannjjm 1944 13 with with IN cord-023095-4dannjjm 1944 14 diseases disease NNS cord-023095-4dannjjm 1944 15 mimicking mimic VBG cord-023095-4dannjjm 1944 16 PH PH NNP cord-023095-4dannjjm 1944 17 . . . cord-023095-4dannjjm 1945 1 To to TO cord-023095-4dannjjm 1945 2 confirm confirm VB cord-023095-4dannjjm 1945 3 that that IN cord-023095-4dannjjm 1945 4 peak peak NN cord-023095-4dannjjm 1945 5 concentrations concentration NNS cord-023095-4dannjjm 1945 6 were be VBD cord-023095-4dannjjm 1945 7 not not RB cord-023095-4dannjjm 1945 8 missed miss VBN cord-023095-4dannjjm 1945 9 ALDO ALDO NNP cord-023095-4dannjjm 1945 10 was be VBD cord-023095-4dannjjm 1945 11 additionally additionally RB cord-023095-4dannjjm 1945 12 measured measure VBN cord-023095-4dannjjm 1945 13 15 15 CD cord-023095-4dannjjm 1945 14 , , , cord-023095-4dannjjm 1945 15 30 30 CD cord-023095-4dannjjm 1945 16 and and CC cord-023095-4dannjjm 1945 17 45 45 CD cord-023095-4dannjjm 1945 18 min min NN cord-023095-4dannjjm 1945 19 after after IN cord-023095-4dannjjm 1945 20 ACTH ACTH NNP cord-023095-4dannjjm 1945 21 in in IN cord-023095-4dannjjm 1945 22 19 19 CD cord-023095-4dannjjm 1945 23 dogs dog NNS cord-023095-4dannjjm 1945 24 ( ( -LRB- cord-023095-4dannjjm 1945 25 5 5 CD cord-023095-4dannjjm 1945 26 with with IN cord-023095-4dannjjm 1945 27 PH PH NNP cord-023095-4dannjjm 1945 28 , , , cord-023095-4dannjjm 1945 29 14 14 CD cord-023095-4dannjjm 1945 30 with with IN cord-023095-4dannjjm 1945 31 PH PH NNP cord-023095-4dannjjm 1945 32 mimicking mimic VBG cord-023095-4dannjjm 1945 33 diseases disease NNS cord-023095-4dannjjm 1945 34 ) ) -RRB- cord-023095-4dannjjm 1945 35 . . . cord-023095-4dannjjm 1946 1 Results result NNS cord-023095-4dannjjm 1946 2 were be VBD cord-023095-4dannjjm 1946 3 analysed analyse VBN cord-023095-4dannjjm 1946 4 by by IN cord-023095-4dannjjm 1946 5 means mean NNS cord-023095-4dannjjm 1946 6 of of IN cord-023095-4dannjjm 1946 7 non non JJ cord-023095-4dannjjm 1946 8 - - JJ cord-023095-4dannjjm 1946 9 parametric parametric JJ cord-023095-4dannjjm 1946 10 statistical statistical JJ cord-023095-4dannjjm 1946 11 methods method NNS cord-023095-4dannjjm 1946 12 ( ( -LRB- cord-023095-4dannjjm 1946 13 p p NN cord-023095-4dannjjm 1946 14 o o NN cord-023095-4dannjjm 1946 15 0.05 0.05 CD cord-023095-4dannjjm 1946 16 ) ) -RRB- cord-023095-4dannjjm 1946 17 . . . cord-023095-4dannjjm 1947 1 Post post JJ cord-023095-4dannjjm 1947 2 - - JJ cord-023095-4dannjjm 1947 3 ACTH ACTH NNP cord-023095-4dannjjm 1947 4 ALDO ALDO NNP cord-023095-4dannjjm 1947 5 was be VBD cord-023095-4dannjjm 1947 6 significantly significantly RB cord-023095-4dannjjm 1947 7 lower low JJR cord-023095-4dannjjm 1947 8 in in IN cord-023095-4dannjjm 1947 9 dogs dog NNS cord-023095-4dannjjm 1947 10 with with IN cord-023095-4dannjjm 1947 11 PH PH NNP cord-023095-4dannjjm 1947 12 ( ( -LRB- cord-023095-4dannjjm 1947 13 0 0 CD cord-023095-4dannjjm 1947 14 - - SYM cord-023095-4dannjjm 1947 15 253 253 CD cord-023095-4dannjjm 1947 16 pg pg NN cord-023095-4dannjjm 1947 17 / / SYM cord-023095-4dannjjm 1947 18 ml ml NN cord-023095-4dannjjm 1947 19 , , , cord-023095-4dannjjm 1947 20 median median JJ cord-023095-4dannjjm 1947 21 0 0 CD cord-023095-4dannjjm 1947 22 pg pg NN cord-023095-4dannjjm 1947 23 / / SYM cord-023095-4dannjjm 1947 24 ml ml NNP cord-023095-4dannjjm 1947 25 ) ) -RRB- cord-023095-4dannjjm 1947 26 than than IN cord-023095-4dannjjm 1947 27 in in IN cord-023095-4dannjjm 1947 28 healthy healthy JJ cord-023095-4dannjjm 1947 29 dogs dog NNS cord-023095-4dannjjm 1947 30 ( ( -LRB- cord-023095-4dannjjm 1947 31 46 46 CD cord-023095-4dannjjm 1947 32 - - SYM cord-023095-4dannjjm 1947 33 602 602 CD cord-023095-4dannjjm 1947 34 pg pg NNP cord-023095-4dannjjm 1947 35 / / SYM cord-023095-4dannjjm 1947 36 ml ml NN cord-023095-4dannjjm 1947 37 , , , cord-023095-4dannjjm 1947 38 median median NN cord-023095-4dannjjm 1947 39 187 187 CD cord-023095-4dannjjm 1947 40 pg pg NN cord-023095-4dannjjm 1947 41 / / SYM cord-023095-4dannjjm 1947 42 ml ml NNP cord-023095-4dannjjm 1947 43 ) ) -RRB- cord-023095-4dannjjm 1947 44 and and CC cord-023095-4dannjjm 1947 45 in in IN cord-023095-4dannjjm 1947 46 dogs dog NNS cord-023095-4dannjjm 1947 47 with with IN cord-023095-4dannjjm 1947 48 PH PH NNP cord-023095-4dannjjm 1947 49 mimicking mimic VBG cord-023095-4dannjjm 1947 50 diseases disease NNS cord-023095-4dannjjm 1947 51 ( ( -LRB- cord-023095-4dannjjm 1947 52 0 0 CD cord-023095-4dannjjm 1947 53 - - SYM cord-023095-4dannjjm 1947 54 639 639 CD cord-023095-4dannjjm 1947 55 pg pg NNP cord-023095-4dannjjm 1947 56 / / SYM cord-023095-4dannjjm 1947 57 ml ml NN cord-023095-4dannjjm 1947 58 , , , cord-023095-4dannjjm 1947 59 median median NN cord-023095-4dannjjm 1947 60 155 155 CD cord-023095-4dannjjm 1947 61 pg pg NN cord-023095-4dannjjm 1947 62 / / SYM cord-023095-4dannjjm 1947 63 ml ml NN cord-023095-4dannjjm 1947 64 ) ) -RRB- cord-023095-4dannjjm 1947 65 . . . cord-023095-4dannjjm 1948 1 Low low JJ cord-023095-4dannjjm 1948 2 post post JJ cord-023095-4dannjjm 1948 3 - - JJ cord-023095-4dannjjm 1948 4 ACTH ACTH NNP cord-023095-4dannjjm 1948 5 ALDO ALDO NNP cord-023095-4dannjjm 1948 6 was be VBD cord-023095-4dannjjm 1948 7 found find VBN cord-023095-4dannjjm 1948 8 in in IN cord-023095-4dannjjm 1948 9 67/70 67/70 CD cord-023095-4dannjjm 1948 10 dogs dog NNS cord-023095-4dannjjm 1948 11 with with IN cord-023095-4dannjjm 1948 12 PH PH NNP cord-023095-4dannjjm 1948 13 , , , cord-023095-4dannjjm 1948 14 in in IN cord-023095-4dannjjm 1948 15 64/67 64/67 CD cord-023095-4dannjjm 1948 16 of of IN cord-023095-4dannjjm 1948 17 them -PRON- PRP cord-023095-4dannjjm 1948 18 levels level NNS cord-023095-4dannjjm 1948 19 were be VBD cord-023095-4dannjjm 1948 20 below below IN cord-023095-4dannjjm 1948 21 the the DT cord-023095-4dannjjm 1948 22 detection detection NN cord-023095-4dannjjm 1948 23 limit limit NN cord-023095-4dannjjm 1948 24 of of IN cord-023095-4dannjjm 1948 25 the the DT cord-023095-4dannjjm 1948 26 assay assay NN cord-023095-4dannjjm 1948 27 . . . cord-023095-4dannjjm 1949 1 Normal normal JJ cord-023095-4dannjjm 1949 2 sodium sodium NN cord-023095-4dannjjm 1949 3 and and CC cord-023095-4dannjjm 1949 4 potassium potassium NN cord-023095-4dannjjm 1949 5 levels level NNS cord-023095-4dannjjm 1949 6 were be VBD cord-023095-4dannjjm 1949 7 found find VBN cord-023095-4dannjjm 1949 8 in in IN cord-023095-4dannjjm 1949 9 5/67 5/67 CD cord-023095-4dannjjm 1949 10 dogs dog NNS cord-023095-4dannjjm 1949 11 ( ( -LRB- cord-023095-4dannjjm 1949 12 7 7 CD cord-023095-4dannjjm 1949 13 % % NN cord-023095-4dannjjm 1949 14 ) ) -RRB- cord-023095-4dannjjm 1949 15 , , , cord-023095-4dannjjm 1949 16 6/67 6/67 CD cord-023095-4dannjjm 1949 17 dogs dog NNS cord-023095-4dannjjm 1949 18 ( ( -LRB- cord-023095-4dannjjm 1949 19 9 9 CD cord-023095-4dannjjm 1949 20 % % NN cord-023095-4dannjjm 1949 21 ) ) -RRB- cord-023095-4dannjjm 1949 22 had have VBD cord-023095-4dannjjm 1949 23 hyponatremia hyponatremia NN cord-023095-4dannjjm 1949 24 and and CC cord-023095-4dannjjm 1949 25 normal normal JJ cord-023095-4dannjjm 1949 26 potassium potassium NN cord-023095-4dannjjm 1949 27 , , , cord-023095-4dannjjm 1949 28 56/67 56/67 CD cord-023095-4dannjjm 1949 29 dogs dog NNS cord-023095-4dannjjm 1949 30 ( ( -LRB- cord-023095-4dannjjm 1949 31 84 84 CD cord-023095-4dannjjm 1949 32 % % NN cord-023095-4dannjjm 1949 33 ) ) -RRB- cord-023095-4dannjjm 1949 34 had have VBD cord-023095-4dannjjm 1949 35 hyponatremia hyponatremia NN cord-023095-4dannjjm 1949 36 and and CC cord-023095-4dannjjm 1949 37 hyperkalemia hyperkalemia NN cord-023095-4dannjjm 1949 38 . . . cord-023095-4dannjjm 1950 1 Electrolyte electrolyte NN cord-023095-4dannjjm 1950 2 abnormalities abnormality NNS cord-023095-4dannjjm 1950 3 ranged range VBD cord-023095-4dannjjm 1950 4 from from IN cord-023095-4dannjjm 1950 5 mild mild JJ cord-023095-4dannjjm 1950 6 to to IN cord-023095-4dannjjm 1950 7 severe severe JJ cord-023095-4dannjjm 1950 8 . . . cord-023095-4dannjjm 1951 1 There there EX cord-023095-4dannjjm 1951 2 was be VBD cord-023095-4dannjjm 1951 3 no no DT cord-023095-4dannjjm 1951 4 correlation correlation NN cord-023095-4dannjjm 1951 5 between between IN cord-023095-4dannjjm 1951 6 post post JJ cord-023095-4dannjjm 1951 7 - - JJ cord-023095-4dannjjm 1951 8 ACTH acth JJ cord-023095-4dannjjm 1951 9 ALDO ALDO NNP cord-023095-4dannjjm 1951 10 and and CC cord-023095-4dannjjm 1951 11 sodium sodium NN cord-023095-4dannjjm 1951 12 and and CC cord-023095-4dannjjm 1951 13 a a DT cord-023095-4dannjjm 1951 14 weak weak JJ cord-023095-4dannjjm 1951 15 correlation correlation NN cord-023095-4dannjjm 1951 16 between between IN cord-023095-4dannjjm 1951 17 post post JJ cord-023095-4dannjjm 1951 18 - - JJ cord-023095-4dannjjm 1951 19 ACTH acth JJ cord-023095-4dannjjm 1951 20 ALDO ALDO NNP cord-023095-4dannjjm 1951 21 and and CC cord-023095-4dannjjm 1951 22 potassium potassium NN cord-023095-4dannjjm 1951 23 ( ( -LRB- cord-023095-4dannjjm 1951 24 r r NN cord-023095-4dannjjm 1951 25 5 5 CD cord-023095-4dannjjm 1951 26 À0.28 à0.28 NN cord-023095-4dannjjm 1951 27 ) ) -RRB- cord-023095-4dannjjm 1951 28 . . . cord-023095-4dannjjm 1952 1 ALDO ALDO NNP cord-023095-4dannjjm 1952 2 concentrations concentration NNS cord-023095-4dannjjm 1952 3 were be VBD cord-023095-4dannjjm 1952 4 not not RB cord-023095-4dannjjm 1952 5 different different JJ cord-023095-4dannjjm 1952 6 30 30 CD cord-023095-4dannjjm 1952 7 , , , cord-023095-4dannjjm 1952 8 45 45 CD cord-023095-4dannjjm 1952 9 and and CC cord-023095-4dannjjm 1952 10 60 60 CD cord-023095-4dannjjm 1952 11 min min NN cord-023095-4dannjjm 1952 12 after after IN cord-023095-4dannjjm 1952 13 ACTH ACTH NNP cord-023095-4dannjjm 1952 14 . . . cord-023095-4dannjjm 1953 1 The the DT cord-023095-4dannjjm 1953 2 results result NNS cord-023095-4dannjjm 1953 3 demonstrate demonstrate VBP cord-023095-4dannjjm 1953 4 that that IN cord-023095-4dannjjm 1953 5 ALDO ALDO NNP cord-023095-4dannjjm 1953 6 levels level NNS cord-023095-4dannjjm 1953 7 are be VBP cord-023095-4dannjjm 1953 8 low low JJ cord-023095-4dannjjm 1953 9 in in IN cord-023095-4dannjjm 1953 10 most most JJS cord-023095-4dannjjm 1953 11 dogs dog NNS cord-023095-4dannjjm 1953 12 with with IN cord-023095-4dannjjm 1953 13 PH PH NNP cord-023095-4dannjjm 1953 14 independent independent JJ cord-023095-4dannjjm 1953 15 of of IN cord-023095-4dannjjm 1953 16 the the DT cord-023095-4dannjjm 1953 17 degree degree NN cord-023095-4dannjjm 1953 18 of of IN cord-023095-4dannjjm 1953 19 electrolyte electrolyte JJ cord-023095-4dannjjm 1953 20 abnormalities abnormality NNS cord-023095-4dannjjm 1953 21 . . . cord-023095-4dannjjm 1954 1 This this DT cord-023095-4dannjjm 1954 2 implicates implicate VBZ cord-023095-4dannjjm 1954 3 that that IN cord-023095-4dannjjm 1954 4 all all DT cord-023095-4dannjjm 1954 5 three three CD cord-023095-4dannjjm 1954 6 zones zone NNS cord-023095-4dannjjm 1954 7 of of IN cord-023095-4dannjjm 1954 8 the the DT cord-023095-4dannjjm 1954 9 adrenal adrenal JJ cord-023095-4dannjjm 1954 10 cortex cortex NNS cord-023095-4dannjjm 1954 11 are be VBP cord-023095-4dannjjm 1954 12 compromised compromise VBN cord-023095-4dannjjm 1954 13 and and CC cord-023095-4dannjjm 1954 14 that that IN cord-023095-4dannjjm 1954 15 there there EX cord-023095-4dannjjm 1954 16 are be VBP cord-023095-4dannjjm 1954 17 mechanisms mechanism NNS cord-023095-4dannjjm 1954 18 which which WDT cord-023095-4dannjjm 1954 19 allow allow VBP cord-023095-4dannjjm 1954 20 maintenance maintenance NN cord-023095-4dannjjm 1954 21 of of IN cord-023095-4dannjjm 1954 22 a a DT cord-023095-4dannjjm 1954 23 normal normal JJ cord-023095-4dannjjm 1954 24 electrolyte electrolyte JJ cord-023095-4dannjjm 1954 25 balance balance NN cord-023095-4dannjjm 1954 26 without without IN cord-023095-4dannjjm 1954 27 ALDO ALDO NNP cord-023095-4dannjjm 1954 28 . . . cord-023095-4dannjjm 1955 1 Definitive definitive JJ cord-023095-4dannjjm 1955 2 diagnosis diagnosis NN cord-023095-4dannjjm 1955 3 of of IN cord-023095-4dannjjm 1955 4 canine canine JJ cord-023095-4dannjjm 1955 5 hypoadrenocorticism hypoadrenocorticism NN cord-023095-4dannjjm 1955 6 ( ( -LRB- cord-023095-4dannjjm 1955 7 HA HA NNP cord-023095-4dannjjm 1955 8 ) ) -RRB- cord-023095-4dannjjm 1955 9 is be VBZ cord-023095-4dannjjm 1955 10 based base VBN cord-023095-4dannjjm 1955 11 on on IN cord-023095-4dannjjm 1955 12 inadequate inadequate JJ cord-023095-4dannjjm 1955 13 cortisol cortisol NN cord-023095-4dannjjm 1955 14 secretion secretion NN cord-023095-4dannjjm 1955 15 following follow VBG cord-023095-4dannjjm 1955 16 adrenocorticotropic adrenocorticotropic JJ cord-023095-4dannjjm 1955 17 hormone hormone NN cord-023095-4dannjjm 1955 18 ( ( -LRB- cord-023095-4dannjjm 1955 19 ACTH ACTH NNP cord-023095-4dannjjm 1955 20 ) ) -RRB- cord-023095-4dannjjm 1955 21 administration administration NN cord-023095-4dannjjm 1955 22 . . . cord-023095-4dannjjm 1956 1 An an DT cord-023095-4dannjjm 1956 2 abnormal abnormal JJ cord-023095-4dannjjm 1956 3 serum serum NN cord-023095-4dannjjm 1956 4 sodium sodium NN cord-023095-4dannjjm 1956 5 to to IN cord-023095-4dannjjm 1956 6 potassium potassium NN cord-023095-4dannjjm 1957 1 ( ( -LRB- cord-023095-4dannjjm 1957 2 Na Na NNP cord-023095-4dannjjm 1957 3 : : : cord-023095-4dannjjm 1958 1 K K NNP cord-023095-4dannjjm 1958 2 ) ) -RRB- cord-023095-4dannjjm 1958 3 ratio ratio NN cord-023095-4dannjjm 1958 4 can can MD cord-023095-4dannjjm 1958 5 be be VB cord-023095-4dannjjm 1958 6 used use VBN cord-023095-4dannjjm 1958 7 to to TO cord-023095-4dannjjm 1958 8 determine determine VB cord-023095-4dannjjm 1958 9 whether whether IN cord-023095-4dannjjm 1958 10 an an DT cord-023095-4dannjjm 1958 11 ACTH ACTH NNP cord-023095-4dannjjm 1958 12 stimulation stimulation NN cord-023095-4dannjjm 1958 13 test test NN cord-023095-4dannjjm 1958 14 is be VBZ cord-023095-4dannjjm 1958 15 warranted warrant VBN cord-023095-4dannjjm 1958 16 . . . cord-023095-4dannjjm 1959 1 The the DT cord-023095-4dannjjm 1959 2 aim aim NN cord-023095-4dannjjm 1959 3 of of IN cord-023095-4dannjjm 1959 4 this this DT cord-023095-4dannjjm 1959 5 study study NN cord-023095-4dannjjm 1959 6 was be VBD cord-023095-4dannjjm 1959 7 to to TO cord-023095-4dannjjm 1959 8 examine examine VB cord-023095-4dannjjm 1959 9 the the DT cord-023095-4dannjjm 1959 10 utility utility NN cord-023095-4dannjjm 1959 11 of of IN cord-023095-4dannjjm 1959 12 combining combine VBG cord-023095-4dannjjm 1959 13 the the DT cord-023095-4dannjjm 1959 14 Na Na NNP cord-023095-4dannjjm 1959 15 : : : cord-023095-4dannjjm 1959 16 K k NN cord-023095-4dannjjm 1959 17 ratio ratio NN cord-023095-4dannjjm 1959 18 with with IN cord-023095-4dannjjm 1959 19 white white JJ cord-023095-4dannjjm 1959 20 blood blood NN cord-023095-4dannjjm 1959 21 cell cell NN cord-023095-4dannjjm 1959 22 counts count VBZ cord-023095-4dannjjm 1959 23 to to TO cord-023095-4dannjjm 1959 24 determine determine VB cord-023095-4dannjjm 1959 25 whether whether IN cord-023095-4dannjjm 1959 26 an an DT cord-023095-4dannjjm 1959 27 ACTH ACTH NNP cord-023095-4dannjjm 1959 28 stimulation stimulation NN cord-023095-4dannjjm 1959 29 test test NN cord-023095-4dannjjm 1959 30 is be VBZ cord-023095-4dannjjm 1959 31 warranted warrant VBN cord-023095-4dannjjm 1959 32 . . . cord-023095-4dannjjm 1960 1 A a DT cord-023095-4dannjjm 1960 2 retrospective retrospective JJ cord-023095-4dannjjm 1960 3 review review NN cord-023095-4dannjjm 1960 4 of of IN cord-023095-4dannjjm 1960 5 medical medical JJ cord-023095-4dannjjm 1960 6 records record NNS cord-023095-4dannjjm 1960 7 of of IN cord-023095-4dannjjm 1960 8 dogs dog NNS cord-023095-4dannjjm 1960 9 examined examine VBN cord-023095-4dannjjm 1960 10 between between IN cord-023095-4dannjjm 1960 11 2005 2005 CD cord-023095-4dannjjm 1960 12 and and CC cord-023095-4dannjjm 1960 13 2009 2009 CD cord-023095-4dannjjm 1960 14 was be VBD cord-023095-4dannjjm 1960 15 performed perform VBN cord-023095-4dannjjm 1960 16 . . . cord-023095-4dannjjm 1961 1 53 53 CD cord-023095-4dannjjm 1961 2 dogs dog NNS cord-023095-4dannjjm 1961 3 diagnosed diagnose VBN cord-023095-4dannjjm 1961 4 with with IN cord-023095-4dannjjm 1961 5 HA HA NNP cord-023095-4dannjjm 1961 6 and and CC cord-023095-4dannjjm 1961 7 110 110 CD cord-023095-4dannjjm 1961 8 control control NN cord-023095-4dannjjm 1961 9 dogs dog NNS cord-023095-4dannjjm 1961 10 , , , cord-023095-4dannjjm 1961 11 in in IN cord-023095-4dannjjm 1961 12 which which WDT cord-023095-4dannjjm 1961 13 a a DT cord-023095-4dannjjm 1961 14 diagnosis diagnosis NN cord-023095-4dannjjm 1961 15 of of IN cord-023095-4dannjjm 1961 16 HA HA NNP cord-023095-4dannjjm 1961 17 was be VBD cord-023095-4dannjjm 1961 18 excluded exclude VBN cord-023095-4dannjjm 1961 19 during during IN cord-023095-4dannjjm 1961 20 the the DT cord-023095-4dannjjm 1961 21 study study NN cord-023095-4dannjjm 1961 22 period period NN cord-023095-4dannjjm 1961 23 , , , cord-023095-4dannjjm 1961 24 were be VBD cord-023095-4dannjjm 1961 25 included include VBN cord-023095-4dannjjm 1961 26 . . . cord-023095-4dannjjm 1962 1 Inclusion inclusion NN cord-023095-4dannjjm 1962 2 criteria criterion NNS cord-023095-4dannjjm 1962 3 for for IN cord-023095-4dannjjm 1962 4 all all DT cord-023095-4dannjjm 1962 5 163 163 CD cord-023095-4dannjjm 1962 6 dogs dog NNS cord-023095-4dannjjm 1962 7 were be VBD cord-023095-4dannjjm 1962 8 hospitalization hospitalization NN cord-023095-4dannjjm 1962 9 with with IN cord-023095-4dannjjm 1962 10 intravenous intravenous JJ cord-023095-4dannjjm 1962 11 fluid fluid NN cord-023095-4dannjjm 1962 12 therapy therapy NN cord-023095-4dannjjm 1962 13 , , , cord-023095-4dannjjm 1962 14 a a DT cord-023095-4dannjjm 1962 15 complete complete JJ cord-023095-4dannjjm 1962 16 blood blood NN cord-023095-4dannjjm 1962 17 count count NN cord-023095-4dannjjm 1962 18 , , , cord-023095-4dannjjm 1962 19 and and CC cord-023095-4dannjjm 1962 20 serum serum NN cord-023095-4dannjjm 1962 21 Na Na NNP cord-023095-4dannjjm 1962 22 and and CC cord-023095-4dannjjm 1962 23 K K NNP cord-023095-4dannjjm 1962 24 measurements measurement NNS cord-023095-4dannjjm 1962 25 at at IN cord-023095-4dannjjm 1962 26 the the DT cord-023095-4dannjjm 1962 27 time time NN cord-023095-4dannjjm 1962 28 of of IN cord-023095-4dannjjm 1962 29 initial initial JJ cord-023095-4dannjjm 1962 30 examination examination NN cord-023095-4dannjjm 1962 31 . . . cord-023095-4dannjjm 1963 1 Dogs dog NNS cord-023095-4dannjjm 1963 2 were be VBD cord-023095-4dannjjm 1963 3 included include VBN cord-023095-4dannjjm 1963 4 in in IN cord-023095-4dannjjm 1963 5 the the DT cord-023095-4dannjjm 1963 6 HA HA NNP cord-023095-4dannjjm 1963 7 group group NN cord-023095-4dannjjm 1963 8 if if IN cord-023095-4dannjjm 1963 9 they -PRON- PRP cord-023095-4dannjjm 1963 10 also also RB cord-023095-4dannjjm 1963 11 had have VBD cord-023095-4dannjjm 1963 12 pre pre VBN cord-023095-4dannjjm 1963 13 and and CC cord-023095-4dannjjm 1963 14 post post VB cord-023095-4dannjjm 1964 1 ACTH ACTH NNP cord-023095-4dannjjm 1964 2 stimulation stimulation NN cord-023095-4dannjjm 1964 3 serum serum NN cord-023095-4dannjjm 1964 4 cortisol cortisol NN cord-023095-4dannjjm 1964 5 concentrations concentration NNS cord-023095-4dannjjm 1965 1 1.0 1.0 CD cord-023095-4dannjjm 1965 2 mg mg NNP cord-023095-4dannjjm 1965 3 / / SYM cord-023095-4dannjjm 1965 4 dl dl NN cord-023095-4dannjjm 1965 5 . . . cord-023095-4dannjjm 1966 1 Dogs dog NNS cord-023095-4dannjjm 1966 2 were be VBD cord-023095-4dannjjm 1966 3 included include VBN cord-023095-4dannjjm 1966 4 in in IN cord-023095-4dannjjm 1966 5 the the DT cord-023095-4dannjjm 1966 6 control control NN cord-023095-4dannjjm 1966 7 group group NN cord-023095-4dannjjm 1966 8 if if IN cord-023095-4dannjjm 1966 9 they -PRON- PRP cord-023095-4dannjjm 1966 10 had have VBD cord-023095-4dannjjm 1966 11 resting rest VBG cord-023095-4dannjjm 1966 12 or or CC cord-023095-4dannjjm 1966 13 post post VB cord-023095-4dannjjm 1967 1 ACTH ACTH NNP cord-023095-4dannjjm 1967 2 stimulation stimulation NN cord-023095-4dannjjm 1967 3 serum serum NN cord-023095-4dannjjm 1967 4 cortisol cortisol NN cord-023095-4dannjjm 1967 5 concentration concentration NN cord-023095-4dannjjm 1967 6 4 4 CD cord-023095-4dannjjm 1968 1 2.0 2.0 CD cord-023095-4dannjjm 1968 2 mg mg NNP cord-023095-4dannjjm 1968 3 / / SYM cord-023095-4dannjjm 1968 4 dl dl NN cord-023095-4dannjjm 1968 5 . . . cord-023095-4dannjjm 1969 1 Exclusion exclusion NN cord-023095-4dannjjm 1969 2 criteria criterion NNS cord-023095-4dannjjm 1969 3 were be VBD cord-023095-4dannjjm 1969 4 recent recent JJ cord-023095-4dannjjm 1969 5 administration administration NN cord-023095-4dannjjm 1969 6 of of IN cord-023095-4dannjjm 1969 7 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 1969 8 , , , cord-023095-4dannjjm 1969 9 prior prior JJ cord-023095-4dannjjm 1969 10 treatment treatment NN cord-023095-4dannjjm 1969 11 of of IN cord-023095-4dannjjm 1969 12 hyperadrenocorticism hyperadrenocorticism NN cord-023095-4dannjjm 1969 13 , , , cord-023095-4dannjjm 1969 14 or or CC cord-023095-4dannjjm 1969 15 serum serum NN cord-023095-4dannjjm 1969 16 cortisol cortisol NN cord-023095-4dannjjm 1969 17 concentration concentration NN cord-023095-4dannjjm 1969 18 4 4 CD cord-023095-4dannjjm 1969 19 1.0 1.0 CD cord-023095-4dannjjm 1969 20 mg mg NNP cord-023095-4dannjjm 1969 21 / / SYM cord-023095-4dannjjm 1969 22 dl dl NNP cord-023095-4dannjjm 1969 23 but but CC cord-023095-4dannjjm 1969 24 2.0 2.0 CD cord-023095-4dannjjm 1969 25 mg mg NNP cord-023095-4dannjjm 1969 26 / / SYM cord-023095-4dannjjm 1969 27 dl dl NN cord-023095-4dannjjm 1969 28 . . . cord-023095-4dannjjm 1970 1 Continuous continuous JJ cord-023095-4dannjjm 1970 2 variables variable NNS cord-023095-4dannjjm 1970 3 were be VBD cord-023095-4dannjjm 1970 4 compared compare VBN cord-023095-4dannjjm 1970 5 between between IN cord-023095-4dannjjm 1970 6 groups group NNS cord-023095-4dannjjm 1970 7 using use VBG cord-023095-4dannjjm 1970 8 the the DT cord-023095-4dannjjm 1970 9 Mann Mann NNP cord-023095-4dannjjm 1970 10 - - HYPH cord-023095-4dannjjm 1970 11 Whitney Whitney NNP cord-023095-4dannjjm 1970 12 U U NNP cord-023095-4dannjjm 1970 13 test test NN cord-023095-4dannjjm 1970 14 . . . cord-023095-4dannjjm 1971 1 Receiver receiver NN cord-023095-4dannjjm 1971 2 operating operating NN cord-023095-4dannjjm 1971 3 characteristic characteristic NN cord-023095-4dannjjm 1971 4 ( ( -LRB- cord-023095-4dannjjm 1971 5 ROC ROC NNP cord-023095-4dannjjm 1971 6 ) ) -RRB- cord-023095-4dannjjm 1971 7 curves curve NNS cord-023095-4dannjjm 1971 8 were be VBD cord-023095-4dannjjm 1971 9 produced produce VBN cord-023095-4dannjjm 1971 10 to to TO cord-023095-4dannjjm 1971 11 assess assess VB cord-023095-4dannjjm 1971 12 the the DT cord-023095-4dannjjm 1971 13 sensitivity sensitivity NN cord-023095-4dannjjm 1971 14 and and CC cord-023095-4dannjjm 1971 15 specificity specificity NN cord-023095-4dannjjm 1971 16 of of IN cord-023095-4dannjjm 1971 17 detecting detect VBG cord-023095-4dannjjm 1971 18 HA HA NNP cord-023095-4dannjjm 1971 19 with with IN cord-023095-4dannjjm 1971 20 various various JJ cord-023095-4dannjjm 1971 21 cutoffs cutoff NNS cord-023095-4dannjjm 1971 22 for for IN cord-023095-4dannjjm 1971 23 each each DT cord-023095-4dannjjm 1971 24 variable variable NN cord-023095-4dannjjm 1971 25 . . . cord-023095-4dannjjm 1972 1 Data Data NNP cord-023095-4dannjjm 1972 2 is be VBZ cord-023095-4dannjjm 1972 3 presented present VBN cord-023095-4dannjjm 1972 4 with with IN cord-023095-4dannjjm 1972 5 95 95 CD cord-023095-4dannjjm 1972 6 % % NN cord-023095-4dannjjm 1972 7 confidence confidence NN cord-023095-4dannjjm 1972 8 intervals interval NNS cord-023095-4dannjjm 1972 9 ( ( -LRB- cord-023095-4dannjjm 1972 10 CI CI NNP cord-023095-4dannjjm 1972 11 ) ) -RRB- cord-023095-4dannjjm 1972 12 and and CC cord-023095-4dannjjm 1972 13 statistical statistical JJ cord-023095-4dannjjm 1972 14 significance significance NN cord-023095-4dannjjm 1972 15 was be VBD cord-023095-4dannjjm 1972 16 defined define VBN cord-023095-4dannjjm 1972 17 as as IN cord-023095-4dannjjm 1972 18 p p NN cord-023095-4dannjjm 1972 19 o o NN cord-023095-4dannjjm 1972 20 0.05 0.05 CD cord-023095-4dannjjm 1972 21 . . . cord-023095-4dannjjm 1973 1 The the DT cord-023095-4dannjjm 1973 2 Na Na NNP cord-023095-4dannjjm 1973 3 : : : cord-023095-4dannjjm 1974 1 K K NNP cord-023095-4dannjjm 1974 2 ratio ratio NN cord-023095-4dannjjm 1974 3 , , , cord-023095-4dannjjm 1974 4 neutrophil neutrophil NN cord-023095-4dannjjm 1974 5 count count NN cord-023095-4dannjjm 1974 6 and and CC cord-023095-4dannjjm 1974 7 neutrophil neutrophil NN cord-023095-4dannjjm 1974 8 : : : cord-023095-4dannjjm 1974 9 lymphocyte lymphocyte NN cord-023095-4dannjjm 1974 10 ratio ratio NN cord-023095-4dannjjm 1974 11 were be VBD cord-023095-4dannjjm 1974 12 significantly significantly RB cord-023095-4dannjjm 1974 13 lower low JJR cord-023095-4dannjjm 1974 14 in in IN cord-023095-4dannjjm 1974 15 dogs dog NNS cord-023095-4dannjjm 1974 16 with with IN cord-023095-4dannjjm 1974 17 HA HA NNP cord-023095-4dannjjm 1974 18 than than IN cord-023095-4dannjjm 1974 19 in in IN cord-023095-4dannjjm 1974 20 dogs dog NNS cord-023095-4dannjjm 1974 21 without without IN cord-023095-4dannjjm 1974 22 HA HA NNP cord-023095-4dannjjm 1974 23 ( ( -LRB- cord-023095-4dannjjm 1974 24 p p NN cord-023095-4dannjjm 1974 25 o o NN cord-023095-4dannjjm 1974 26 0.01 0.01 CD cord-023095-4dannjjm 1974 27 for for IN cord-023095-4dannjjm 1974 28 each each DT cord-023095-4dannjjm 1974 29 ) ) -RRB- cord-023095-4dannjjm 1974 30 . . . cord-023095-4dannjjm 1975 1 Lymphocyte lymphocyte NN cord-023095-4dannjjm 1975 2 and and CC cord-023095-4dannjjm 1975 3 eosinophil eosinophil NN cord-023095-4dannjjm 1975 4 counts count NNS cord-023095-4dannjjm 1975 5 were be VBD cord-023095-4dannjjm 1975 6 significantly significantly RB cord-023095-4dannjjm 1975 7 higher high JJR cord-023095-4dannjjm 1975 8 in in IN cord-023095-4dannjjm 1975 9 dogs dog NNS cord-023095-4dannjjm 1975 10 with with IN cord-023095-4dannjjm 1975 11 HA HA NNP cord-023095-4dannjjm 1975 12 compared compare VBN cord-023095-4dannjjm 1975 13 to to IN cord-023095-4dannjjm 1975 14 dogs dog NNS cord-023095-4dannjjm 1975 15 without without IN cord-023095-4dannjjm 1975 16 HA HA NNP cord-023095-4dannjjm 1975 17 ( ( -LRB- cord-023095-4dannjjm 1975 18 p p NN cord-023095-4dannjjm 1975 19 o o NN cord-023095-4dannjjm 1975 20 0.001 0.001 CD cord-023095-4dannjjm 1975 21 for for IN cord-023095-4dannjjm 1975 22 each each DT cord-023095-4dannjjm 1975 23 ) ) -RRB- cord-023095-4dannjjm 1975 24 . . . cord-023095-4dannjjm 1976 1 The the DT cord-023095-4dannjjm 1976 2 areas area NNS cord-023095-4dannjjm 1976 3 under under IN cord-023095-4dannjjm 1976 4 the the DT cord-023095-4dannjjm 1976 5 curve curve NN cord-023095-4dannjjm 1976 6 by by IN cord-023095-4dannjjm 1976 7 ROC ROC NNP cord-023095-4dannjjm 1976 8 analysis analysis NN cord-023095-4dannjjm 1976 9 were be VBD cord-023095-4dannjjm 1976 10 largest large JJS cord-023095-4dannjjm 1976 11 for for IN cord-023095-4dannjjm 1976 12 Na Na NNP cord-023095-4dannjjm 1976 13 : : : cord-023095-4dannjjm 1976 14 K k NN cord-023095-4dannjjm 1976 15 ratio ratio NN cord-023095-4dannjjm 1976 16 ( ( -LRB- cord-023095-4dannjjm 1976 17 0.87 0.87 CD cord-023095-4dannjjm 1976 18 , , , cord-023095-4dannjjm 1976 19 CI:0.81 CI:0.81 NNP cord-023095-4dannjjm 1976 20 - - HYPH cord-023095-4dannjjm 1976 21 0.92 0.92 CD cord-023095-4dannjjm 1976 22 ) ) -RRB- cord-023095-4dannjjm 1976 23 and and CC cord-023095-4dannjjm 1976 24 lymphocyte lymphocyte NN cord-023095-4dannjjm 1976 25 count count NN cord-023095-4dannjjm 1976 26 ( ( -LRB- cord-023095-4dannjjm 1976 27 0.85 0.85 CD cord-023095-4dannjjm 1976 28 , , , cord-023095-4dannjjm 1976 29 CI:0.78 CI:0.78 NNP cord-023095-4dannjjm 1976 30 - - HYPH cord-023095-4dannjjm 1976 31 0.90 0.90 CD cord-023095-4dannjjm 1976 32 ) ) -RRB- cord-023095-4dannjjm 1976 33 . . . cord-023095-4dannjjm 1977 1 A a DT cord-023095-4dannjjm 1977 2 Na Na NNP cord-023095-4dannjjm 1977 3 : : : cord-023095-4dannjjm 1977 4 K k NN cord-023095-4dannjjm 1977 5 ratio ratio NN cord-023095-4dannjjm 1977 6 39.6 39.6 CD cord-023095-4dannjjm 1977 7 was be VBD cord-023095-4dannjjm 1977 8 100 100 CD cord-023095-4dannjjm 1977 9 % % NN cord-023095-4dannjjm 1977 10 sensitive sensitive JJ cord-023095-4dannjjm 1977 11 ( ( -LRB- cord-023095-4dannjjm 1977 12 CI:93 CI:93 NNP cord-023095-4dannjjm 1977 13 - - SYM cord-023095-4dannjjm 1977 14 100 100 CD cord-023095-4dannjjm 1977 15 % % NN cord-023095-4dannjjm 1977 16 ) ) -RRB- cord-023095-4dannjjm 1977 17 but but CC cord-023095-4dannjjm 1977 18 only only RB cord-023095-4dannjjm 1977 19 15 15 CD cord-023095-4dannjjm 1977 20 % % NN cord-023095-4dannjjm 1977 21 specific specific JJ cord-023095-4dannjjm 1977 22 ( ( -LRB- cord-023095-4dannjjm 1977 23 CI:9 ci:9 CD cord-023095-4dannjjm 1977 24 - - : cord-023095-4dannjjm 1977 25 23 23 CD cord-023095-4dannjjm 1977 26 % % NN cord-023095-4dannjjm 1977 27 ) ) -RRB- cord-023095-4dannjjm 1977 28 for for IN cord-023095-4dannjjm 1977 29 detecting detect VBG cord-023095-4dannjjm 1977 30 HA HA NNP cord-023095-4dannjjm 1977 31 . . . cord-023095-4dannjjm 1978 1 A a DT cord-023095-4dannjjm 1978 2 lymphocyte lymphocyte NN cord-023095-4dannjjm 1978 3 count count NN cord-023095-4dannjjm 1978 4 ! ! . cord-023095-4dannjjm 1979 1 0.77 0.77 CD cord-023095-4dannjjm 1979 2 x10 x10 CD cord-023095-4dannjjm 1979 3 3 3 CD cord-023095-4dannjjm 1979 4 cells cell NNS cord-023095-4dannjjm 1979 5 / / SYM cord-023095-4dannjjm 1979 6 mL ml NN cord-023095-4dannjjm 1979 7 was be VBD cord-023095-4dannjjm 1979 8 100 100 CD cord-023095-4dannjjm 1979 9 % % NN cord-023095-4dannjjm 1979 10 sensitive sensitive JJ cord-023095-4dannjjm 1979 11 ( ( -LRB- cord-023095-4dannjjm 1979 12 CI:93 CI:93 NNP cord-023095-4dannjjm 1979 13 - - SYM cord-023095-4dannjjm 1979 14 100 100 CD cord-023095-4dannjjm 1979 15 % % NN cord-023095-4dannjjm 1979 16 ) ) -RRB- cord-023095-4dannjjm 1979 17 and and CC cord-023095-4dannjjm 1979 18 35 35 CD cord-023095-4dannjjm 1979 19 % % NN cord-023095-4dannjjm 1979 20 specific specific JJ cord-023095-4dannjjm 1979 21 ( ( -LRB- cord-023095-4dannjjm 1979 22 CI:27 CI:27 NNP cord-023095-4dannjjm 1979 23 - - SYM cord-023095-4dannjjm 1979 24 45 45 CD cord-023095-4dannjjm 1979 25 % % NN cord-023095-4dannjjm 1979 26 ) ) -RRB- cord-023095-4dannjjm 1979 27 . . . cord-023095-4dannjjm 1980 1 Conversely conversely RB cord-023095-4dannjjm 1980 2 a a DT cord-023095-4dannjjm 1980 3 Na Na NNP cord-023095-4dannjjm 1980 4 : : : cord-023095-4dannjjm 1980 5 K k NN cord-023095-4dannjjm 1980 6 ratio ratio NN cord-023095-4dannjjm 1980 7 20.1 20.1 CD cord-023095-4dannjjm 1980 8 was be VBD cord-023095-4dannjjm 1980 9 51 51 CD cord-023095-4dannjjm 1980 10 % % NN cord-023095-4dannjjm 1980 11 sensitive sensitive JJ cord-023095-4dannjjm 1980 12 ( ( -LRB- cord-023095-4dannjjm 1980 13 CI:37 CI:37 NNP cord-023095-4dannjjm 1980 14 - - HYPH cord-023095-4dannjjm 1980 15 65 65 CD cord-023095-4dannjjm 1980 16 % % NN cord-023095-4dannjjm 1980 17 ) ) -RRB- cord-023095-4dannjjm 1980 18 but but CC cord-023095-4dannjjm 1980 19 100 100 CD cord-023095-4dannjjm 1980 20 % % NN cord-023095-4dannjjm 1980 21 specific specific JJ cord-023095-4dannjjm 1980 22 ( ( -LRB- cord-023095-4dannjjm 1980 23 CI:97 CI:97 NNP cord-023095-4dannjjm 1980 24 - - HYPH cord-023095-4dannjjm 1980 25 100 100 CD cord-023095-4dannjjm 1980 26 % % NN cord-023095-4dannjjm 1980 27 ) ) -RRB- cord-023095-4dannjjm 1980 28 and and CC cord-023095-4dannjjm 1980 29 a a DT cord-023095-4dannjjm 1980 30 lymphocyte lymphocyte NN cord-023095-4dannjjm 1980 31 count count NN cord-023095-4dannjjm 1980 32 ! ! . cord-023095-4dannjjm 1981 1 6.1 6.1 CD cord-023095-4dannjjm 1981 2 Â â CD cord-023095-4dannjjm 1981 3 10 10 CD cord-023095-4dannjjm 1981 4 3 3 CD cord-023095-4dannjjm 1981 5 cells cell NNS cord-023095-4dannjjm 1981 6 / / SYM cord-023095-4dannjjm 1981 7 mL ml NN cord-023095-4dannjjm 1981 8 was be VBD cord-023095-4dannjjm 1981 9 9 9 CD cord-023095-4dannjjm 1981 10 % % NN cord-023095-4dannjjm 1981 11 sensitive sensitive JJ cord-023095-4dannjjm 1981 12 ( ( -LRB- cord-023095-4dannjjm 1981 13 CI:3 CI:3 NFP cord-023095-4dannjjm 1981 14 - - : cord-023095-4dannjjm 1981 15 20 20 CD cord-023095-4dannjjm 1981 16 % % NN cord-023095-4dannjjm 1981 17 ) ) -RRB- cord-023095-4dannjjm 1981 18 but but CC cord-023095-4dannjjm 1981 19 100 100 CD cord-023095-4dannjjm 1981 20 % % NN cord-023095-4dannjjm 1981 21 specific specific JJ cord-023095-4dannjjm 1981 22 ( ( -LRB- cord-023095-4dannjjm 1981 23 CI:97 CI:97 NNP cord-023095-4dannjjm 1981 24 - - HYPH cord-023095-4dannjjm 1981 25 100 100 CD cord-023095-4dannjjm 1981 26 % % NN cord-023095-4dannjjm 1981 27 ) ) -RRB- cord-023095-4dannjjm 1981 28 . . . cord-023095-4dannjjm 1982 1 A a DT cord-023095-4dannjjm 1982 2 Na Na NNP cord-023095-4dannjjm 1982 3 : : : cord-023095-4dannjjm 1982 4 K k NN cord-023095-4dannjjm 1982 5 ratio ratio NN cord-023095-4dannjjm 1982 6 35.5 35.5 CD cord-023095-4dannjjm 1982 7 was be VBD cord-023095-4dannjjm 1982 8 96 96 CD cord-023095-4dannjjm 1982 9 % % NN cord-023095-4dannjjm 1982 10 sensitive sensitive JJ cord-023095-4dannjjm 1982 11 ( ( -LRB- cord-023095-4dannjjm 1982 12 CI:87 CI:87 NNP cord-023095-4dannjjm 1982 13 - - HYPH cord-023095-4dannjjm 1982 14 100 100 CD cord-023095-4dannjjm 1982 15 % % NN cord-023095-4dannjjm 1982 16 ) ) -RRB- cord-023095-4dannjjm 1982 17 and and CC cord-023095-4dannjjm 1982 18 35 35 CD cord-023095-4dannjjm 1982 19 % % NN cord-023095-4dannjjm 1982 20 specific specific JJ cord-023095-4dannjjm 1982 21 ( ( -LRB- cord-023095-4dannjjm 1982 22 CI:26 CI:26 NNP cord-023095-4dannjjm 1982 23 - - HYPH cord-023095-4dannjjm 1982 24 44 44 CD cord-023095-4dannjjm 1982 25 % % NN cord-023095-4dannjjm 1982 26 ) ) -RRB- cord-023095-4dannjjm 1982 27 for for IN cord-023095-4dannjjm 1982 28 detection detection NN cord-023095-4dannjjm 1982 29 of of IN cord-023095-4dannjjm 1982 30 HA HA NNP cord-023095-4dannjjm 1982 31 and and CC cord-023095-4dannjjm 1982 32 a a DT cord-023095-4dannjjm 1982 33 lymphocyte lymphocyte NN cord-023095-4dannjjm 1982 34 count count NN cord-023095-4dannjjm 1982 35 ! ! . cord-023095-4dannjjm 1983 1 0.79 0.79 CD cord-023095-4dannjjm 1983 2 Â â CD cord-023095-4dannjjm 1983 3 10 10 CD cord-023095-4dannjjm 1983 4 3 3 CD cord-023095-4dannjjm 1983 5 cells cell NNS cord-023095-4dannjjm 1983 6 / / SYM cord-023095-4dannjjm 1983 7 mL ml NN cord-023095-4dannjjm 1983 8 was be VBD cord-023095-4dannjjm 1983 9 98 98 CD cord-023095-4dannjjm 1983 10 % % NN cord-023095-4dannjjm 1983 11 sensitive sensitive JJ cord-023095-4dannjjm 1983 12 ( ( -LRB- cord-023095-4dannjjm 1983 13 CI:90 CI:90 NNP cord-023095-4dannjjm 1983 14 - - HYPH cord-023095-4dannjjm 1983 15 100 100 CD cord-023095-4dannjjm 1983 16 % % NN cord-023095-4dannjjm 1983 17 ) ) -RRB- cord-023095-4dannjjm 1983 18 and and CC cord-023095-4dannjjm 1983 19 36 36 CD cord-023095-4dannjjm 1983 20 % % NN cord-023095-4dannjjm 1983 21 specific specific JJ cord-023095-4dannjjm 1983 22 ( ( -LRB- cord-023095-4dannjjm 1983 23 CI:27 CI:27 NNP cord-023095-4dannjjm 1983 24 - - SYM cord-023095-4dannjjm 1983 25 46 46 CD cord-023095-4dannjjm 1983 26 % % NN cord-023095-4dannjjm 1983 27 ) ) -RRB- cord-023095-4dannjjm 1983 28 for for IN cord-023095-4dannjjm 1983 29 detection detection NN cord-023095-4dannjjm 1983 30 of of IN cord-023095-4dannjjm 1983 31 HA HA NNP cord-023095-4dannjjm 1983 32 . . . cord-023095-4dannjjm 1984 1 A a DT cord-023095-4dannjjm 1984 2 combination combination NN cord-023095-4dannjjm 1984 3 of of IN cord-023095-4dannjjm 1984 4 this this DT cord-023095-4dannjjm 1984 5 Na Na NNP cord-023095-4dannjjm 1984 6 : : : cord-023095-4dannjjm 1984 7 K k NN cord-023095-4dannjjm 1984 8 ratio ratio NN cord-023095-4dannjjm 1984 9 ( ( -LRB- cord-023095-4dannjjm 1984 10 35.5 35.5 CD cord-023095-4dannjjm 1984 11 ) ) -RRB- cord-023095-4dannjjm 1984 12 and and CC cord-023095-4dannjjm 1984 13 lymphocyte lymphocyte NN cord-023095-4dannjjm 1984 14 count count NN cord-023095-4dannjjm 1984 15 ( ( -LRB- cord-023095-4dannjjm 1984 16 ! ! . cord-023095-4dannjjm 1985 1 0.79 0.79 CD cord-023095-4dannjjm 1985 2 Â â CD cord-023095-4dannjjm 1985 3 10 10 CD cord-023095-4dannjjm 1985 4 3 3 CD cord-023095-4dannjjm 1985 5 cells cell NNS cord-023095-4dannjjm 1985 6 / / SYM cord-023095-4dannjjm 1985 7 mL ml NN cord-023095-4dannjjm 1985 8 ) ) -RRB- cord-023095-4dannjjm 1985 9 was be VBD cord-023095-4dannjjm 1985 10 96 96 CD cord-023095-4dannjjm 1985 11 % % NN cord-023095-4dannjjm 1985 12 sensitive sensitive JJ cord-023095-4dannjjm 1985 13 ( ( -LRB- cord-023095-4dannjjm 1985 14 CI:87 CI:87 NNP cord-023095-4dannjjm 1985 15 - - HYPH cord-023095-4dannjjm 1985 16 100 100 CD cord-023095-4dannjjm 1985 17 % % NN cord-023095-4dannjjm 1985 18 ) ) -RRB- cord-023095-4dannjjm 1985 19 and and CC cord-023095-4dannjjm 1985 20 55 55 CD cord-023095-4dannjjm 1985 21 % % NN cord-023095-4dannjjm 1985 22 specific specific JJ cord-023095-4dannjjm 1985 23 ( ( -LRB- cord-023095-4dannjjm 1985 24 CI:47 CI:47 NNP cord-023095-4dannjjm 1985 25 - - : cord-023095-4dannjjm 1985 26 66 66 CD cord-023095-4dannjjm 1985 27 % % NN cord-023095-4dannjjm 1985 28 ) ) -RRB- cord-023095-4dannjjm 1985 29 for for IN cord-023095-4dannjjm 1985 30 detection detection NN cord-023095-4dannjjm 1985 31 of of IN cord-023095-4dannjjm 1985 32 HA HA NNP cord-023095-4dannjjm 1985 33 . . . cord-023095-4dannjjm 1986 1 These these DT cord-023095-4dannjjm 1986 2 results result NNS cord-023095-4dannjjm 1986 3 indicate indicate VBP cord-023095-4dannjjm 1986 4 that that IN cord-023095-4dannjjm 1986 5 the the DT cord-023095-4dannjjm 1986 6 combination combination NN cord-023095-4dannjjm 1986 7 of of IN cord-023095-4dannjjm 1986 8 lymphocyte lymphocyte NN cord-023095-4dannjjm 1986 9 count count NN cord-023095-4dannjjm 1986 10 and and CC cord-023095-4dannjjm 1986 11 Na Na NNP cord-023095-4dannjjm 1986 12 : : : cord-023095-4dannjjm 1986 13 K k NN cord-023095-4dannjjm 1986 14 ratio ratio NN cord-023095-4dannjjm 1986 15 results result NNS cord-023095-4dannjjm 1986 16 in in IN cord-023095-4dannjjm 1986 17 a a DT cord-023095-4dannjjm 1986 18 better well JJR cord-023095-4dannjjm 1986 19 screening screening NN cord-023095-4dannjjm 1986 20 test test NN cord-023095-4dannjjm 1986 21 for for IN cord-023095-4dannjjm 1986 22 HA HA NNP cord-023095-4dannjjm 1986 23 than than IN cord-023095-4dannjjm 1986 24 the the DT cord-023095-4dannjjm 1986 25 use use NN cord-023095-4dannjjm 1986 26 of of IN cord-023095-4dannjjm 1986 27 the the DT cord-023095-4dannjjm 1986 28 Na Na NNP cord-023095-4dannjjm 1986 29 : : : cord-023095-4dannjjm 1986 30 K k NN cord-023095-4dannjjm 1986 31 ratio ratio NN cord-023095-4dannjjm 1986 32 alone alone RB cord-023095-4dannjjm 1986 33 . . . cord-023095-4dannjjm 1987 1 Pheochromocytoma Pheochromocytoma NNP cord-023095-4dannjjm 1987 2 is be VBZ cord-023095-4dannjjm 1987 3 a a DT cord-023095-4dannjjm 1987 4 malignant malignant JJ cord-023095-4dannjjm 1987 5 , , , cord-023095-4dannjjm 1987 6 catecholamine catecholamine NN cord-023095-4dannjjm 1987 7 - - HYPH cord-023095-4dannjjm 1987 8 producing produce VBG cord-023095-4dannjjm 1987 9 , , , cord-023095-4dannjjm 1987 10 adrenomedullary adrenomedullary NN cord-023095-4dannjjm 1987 11 tumor tumor NN cord-023095-4dannjjm 1987 12 . . . cord-023095-4dannjjm 1988 1 Clinical clinical JJ cord-023095-4dannjjm 1988 2 signs sign NNS cord-023095-4dannjjm 1988 3 resulting result VBG cord-023095-4dannjjm 1988 4 from from IN cord-023095-4dannjjm 1988 5 excessive excessive JJ cord-023095-4dannjjm 1988 6 catecholamine catecholamine NN cord-023095-4dannjjm 1988 7 secretion secretion NN cord-023095-4dannjjm 1988 8 are be VBP cord-023095-4dannjjm 1988 9 typically typically RB cord-023095-4dannjjm 1988 10 non non JJ cord-023095-4dannjjm 1988 11 - - JJ cord-023095-4dannjjm 1988 12 specific specific JJ cord-023095-4dannjjm 1988 13 , , , cord-023095-4dannjjm 1988 14 making make VBG cord-023095-4dannjjm 1988 15 differentiation differentiation NN cord-023095-4dannjjm 1988 16 from from IN cord-023095-4dannjjm 1988 17 other other JJ cord-023095-4dannjjm 1988 18 adrenal adrenal JJ cord-023095-4dannjjm 1988 19 tumors tumor NNS cord-023095-4dannjjm 1988 20 a a DT cord-023095-4dannjjm 1988 21 challenge challenge NN cord-023095-4dannjjm 1988 22 . . . cord-023095-4dannjjm 1989 1 Elevated elevated JJ cord-023095-4dannjjm 1989 2 plasma plasma NN cord-023095-4dannjjm 1989 3 concentrations concentration NNS cord-023095-4dannjjm 1989 4 of of IN cord-023095-4dannjjm 1989 5 the the DT cord-023095-4dannjjm 1989 6 catecholamine catecholamine NN cord-023095-4dannjjm 1989 7 breakdown breakdown NN cord-023095-4dannjjm 1989 8 products product NNS cord-023095-4dannjjm 1989 9 metanephrine metanephrine NNP cord-023095-4dannjjm 1989 10 ( ( -LRB- cord-023095-4dannjjm 1989 11 MN MN NNP cord-023095-4dannjjm 1989 12 ) ) -RRB- cord-023095-4dannjjm 1989 13 and and CC cord-023095-4dannjjm 1989 14 normetanephrine normetanephrine NNP cord-023095-4dannjjm 1989 15 ( ( -LRB- cord-023095-4dannjjm 1989 16 NMN NMN NNP cord-023095-4dannjjm 1989 17 ) ) -RRB- cord-023095-4dannjjm 1989 18 are be VBP cord-023095-4dannjjm 1989 19 used use VBN cord-023095-4dannjjm 1989 20 to to TO cord-023095-4dannjjm 1989 21 identify identify VB cord-023095-4dannjjm 1989 22 pheochromocytoma pheochromocytoma NN cord-023095-4dannjjm 1989 23 in in IN cord-023095-4dannjjm 1989 24 humans human NNS cord-023095-4dannjjm 1989 25 . . . cord-023095-4dannjjm 1990 1 This this DT cord-023095-4dannjjm 1990 2 study study NN cord-023095-4dannjjm 1990 3 tested test VBD cord-023095-4dannjjm 1990 4 the the DT cord-023095-4dannjjm 1990 5 hypothesis hypothesis NN cord-023095-4dannjjm 1990 6 that that WDT cord-023095-4dannjjm 1990 7 plasma plasma NN cord-023095-4dannjjm 1990 8 metanephrine metanephrine NN cord-023095-4dannjjm 1990 9 concentrations concentration NNS cord-023095-4dannjjm 1990 10 are be VBP cord-023095-4dannjjm 1990 11 greater great JJR cord-023095-4dannjjm 1990 12 in in IN cord-023095-4dannjjm 1990 13 dogs dog NNS cord-023095-4dannjjm 1990 14 with with IN cord-023095-4dannjjm 1990 15 pheochromocytoma pheochromocytoma NN cord-023095-4dannjjm 1990 16 than than IN cord-023095-4dannjjm 1990 17 in in IN cord-023095-4dannjjm 1990 18 dogs dog NNS cord-023095-4dannjjm 1990 19 with with IN cord-023095-4dannjjm 1990 20 other other JJ cord-023095-4dannjjm 1990 21 adrenal adrenal JJ cord-023095-4dannjjm 1990 22 neoplasms neoplasm NNS cord-023095-4dannjjm 1990 23 , , , cord-023095-4dannjjm 1990 24 healthy healthy JJ cord-023095-4dannjjm 1990 25 dogs dog NNS cord-023095-4dannjjm 1990 26 and and CC cord-023095-4dannjjm 1990 27 dogs dog NNS cord-023095-4dannjjm 1990 28 with with IN cord-023095-4dannjjm 1990 29 non non JJ cord-023095-4dannjjm 1990 30 - - JJ cord-023095-4dannjjm 1990 31 adrenal adrenal JJ cord-023095-4dannjjm 1990 32 illness illness NN cord-023095-4dannjjm 1990 33 . . . cord-023095-4dannjjm 1991 1 EDTA EDTA NNP cord-023095-4dannjjm 1991 2 plasma plasma NN cord-023095-4dannjjm 1991 3 was be VBD cord-023095-4dannjjm 1991 4 collected collect VBN cord-023095-4dannjjm 1991 5 from from IN cord-023095-4dannjjm 1991 6 healthy healthy JJ cord-023095-4dannjjm 1991 7 dogs dog NNS cord-023095-4dannjjm 1991 8 and and CC cord-023095-4dannjjm 1991 9 unwell unwell JJ cord-023095-4dannjjm 1991 10 , , , cord-023095-4dannjjm 1991 11 hospitalized hospitalize VBN cord-023095-4dannjjm 1991 12 dogs dog NNS cord-023095-4dannjjm 1991 13 with with IN cord-023095-4dannjjm 1991 14 non non JJ cord-023095-4dannjjm 1991 15 - - JJ cord-023095-4dannjjm 1991 16 adrenal adrenal JJ cord-023095-4dannjjm 1991 17 illness illness NN cord-023095-4dannjjm 1991 18 , , , cord-023095-4dannjjm 1991 19 pheochromocytoma pheochromocytoma NN cord-023095-4dannjjm 1991 20 and and CC cord-023095-4dannjjm 1991 21 cortical cortical JJ cord-023095-4dannjjm 1991 22 tumors tumor NNS cord-023095-4dannjjm 1991 23 between between IN cord-023095-4dannjjm 1991 24 April April NNP cord-023095-4dannjjm 1991 25 2007 2007 CD cord-023095-4dannjjm 1991 26 and and CC cord-023095-4dannjjm 1991 27 October October NNP cord-023095-4dannjjm 1991 28 2010 2010 CD cord-023095-4dannjjm 1991 29 . . . cord-023095-4dannjjm 1992 1 Samples sample NNS cord-023095-4dannjjm 1992 2 were be VBD cord-023095-4dannjjm 1992 3 stored store VBN cord-023095-4dannjjm 1992 4 at at IN cord-023095-4dannjjm 1992 5 À801C À801C NNPS cord-023095-4dannjjm 1992 6 before before IN cord-023095-4dannjjm 1992 7 measurement measurement NN cord-023095-4dannjjm 1992 8 of of IN cord-023095-4dannjjm 1992 9 free free JJ cord-023095-4dannjjm 1992 10 MN MN NNP cord-023095-4dannjjm 1992 11 and and CC cord-023095-4dannjjm 1992 12 NMN NMN NNP cord-023095-4dannjjm 1992 13 concentrations concentration NNS cord-023095-4dannjjm 1992 14 using use VBG cord-023095-4dannjjm 1992 15 high high JJ cord-023095-4dannjjm 1992 16 pressure pressure NN cord-023095-4dannjjm 1992 17 liquid liquid NN cord-023095-4dannjjm 1992 18 chromatography chromatography NN cord-023095-4dannjjm 1992 19 at at IN cord-023095-4dannjjm 1992 20 the the DT cord-023095-4dannjjm 1992 21 Central Central NNP cord-023095-4dannjjm 1992 22 Laboratory Laboratory NNP cord-023095-4dannjjm 1992 23 for for IN cord-023095-4dannjjm 1992 24 Clinical Clinical NNP cord-023095-4dannjjm 1992 25 Chemistry Chemistry NNP cord-023095-4dannjjm 1992 26 at at IN cord-023095-4dannjjm 1992 27 the the DT cord-023095-4dannjjm 1992 28 University University NNP cord-023095-4dannjjm 1992 29 of of IN cord-023095-4dannjjm 1992 30 Groningen Groningen NNP cord-023095-4dannjjm 1992 31 ( ( -LRB- cord-023095-4dannjjm 1992 32 33 33 CD cord-023095-4dannjjm 1992 33 samples sample NNS cord-023095-4dannjjm 1992 34 ) ) -RRB- cord-023095-4dannjjm 1992 35 or or CC cord-023095-4dannjjm 1992 36 the the DT cord-023095-4dannjjm 1992 37 Mayo Mayo NNP cord-023095-4dannjjm 1992 38 Clinic Clinic NNP cord-023095-4dannjjm 1992 39 , , , cord-023095-4dannjjm 1992 40 Rochester Rochester NNP cord-023095-4dannjjm 1992 41 , , , cord-023095-4dannjjm 1992 42 Minnesota Minnesota NNP cord-023095-4dannjjm 1992 43 ( ( -LRB- cord-023095-4dannjjm 1992 44 7 7 CD cord-023095-4dannjjm 1992 45 samples sample NNS cord-023095-4dannjjm 1992 46 ) ) -RRB- cord-023095-4dannjjm 1992 47 . . . cord-023095-4dannjjm 1993 1 Kruskal Kruskal NNP cord-023095-4dannjjm 1993 2 - - HYPH cord-023095-4dannjjm 1993 3 Wallis Wallis NNP cord-023095-4dannjjm 1993 4 tests test NNS cord-023095-4dannjjm 1993 5 followed follow VBN cord-023095-4dannjjm 1993 6 by by IN cord-023095-4dannjjm 1993 7 Dunn Dunn NNP cord-023095-4dannjjm 1993 8 's 's POS cord-023095-4dannjjm 1993 9 multiple multiple JJ cord-023095-4dannjjm 1993 10 comparison comparison NN cord-023095-4dannjjm 1993 11 analysis analysis NN cord-023095-4dannjjm 1993 12 were be VBD cord-023095-4dannjjm 1993 13 used use VBN cord-023095-4dannjjm 1993 14 to to TO cord-023095-4dannjjm 1993 15 compare compare VB cord-023095-4dannjjm 1993 16 results result NNS cord-023095-4dannjjm 1993 17 between between IN cord-023095-4dannjjm 1993 18 groups group NNS cord-023095-4dannjjm 1993 19 . . . cord-023095-4dannjjm 1994 1 Significance significance NN cord-023095-4dannjjm 1994 2 was be VBD cord-023095-4dannjjm 1994 3 set set VBN cord-023095-4dannjjm 1994 4 at at IN cord-023095-4dannjjm 1995 1 P p NN cord-023095-4dannjjm 1995 2 o o NN cord-023095-4dannjjm 1995 3 0.05 0.05 CD cord-023095-4dannjjm 1995 4 . . . cord-023095-4dannjjm 1996 1 Results result NNS cord-023095-4dannjjm 1996 2 are be VBP cord-023095-4dannjjm 1996 3 reported report VBN cord-023095-4dannjjm 1996 4 as as IN cord-023095-4dannjjm 1996 5 median median JJ cord-023095-4dannjjm 1996 6 [ [ -LRB- cord-023095-4dannjjm 1996 7 range range NN cord-023095-4dannjjm 1996 8 ] ] -RRB- cord-023095-4dannjjm 1996 9 . . . cord-023095-4dannjjm 1997 1 Eight eight CD cord-023095-4dannjjm 1997 2 dogs dog NNS cord-023095-4dannjjm 1997 3 with with IN cord-023095-4dannjjm 1997 4 pheochromocytoma pheochromocytoma NN cord-023095-4dannjjm 1997 5 , , , cord-023095-4dannjjm 1997 6 5 5 CD cord-023095-4dannjjm 1997 7 healthy healthy JJ cord-023095-4dannjjm 1997 8 dogs dog NNS cord-023095-4dannjjm 1997 9 , , , cord-023095-4dannjjm 1997 10 15 15 CD cord-023095-4dannjjm 1997 11 dogs dog NNS cord-023095-4dannjjm 1997 12 with with IN cord-023095-4dannjjm 1997 13 non non JJ cord-023095-4dannjjm 1997 14 - - JJ cord-023095-4dannjjm 1997 15 adrenal adrenal JJ cord-023095-4dannjjm 1997 16 illness illness NN cord-023095-4dannjjm 1997 17 and and CC cord-023095-4dannjjm 1997 18 12 12 CD cord-023095-4dannjjm 1997 19 dogs dog NNS cord-023095-4dannjjm 1997 20 with with IN cord-023095-4dannjjm 1997 21 cortical cortical JJ cord-023095-4dannjjm 1997 22 tumors tumor NNS cord-023095-4dannjjm 1997 23 were be VBD cord-023095-4dannjjm 1997 24 sampled sample VBN cord-023095-4dannjjm 1997 25 . . . cord-023095-4dannjjm 1998 1 Pheochromocytoma Pheochromocytoma NNP cord-023095-4dannjjm 1998 2 was be VBD cord-023095-4dannjjm 1998 3 diagnosed diagnose VBN cord-023095-4dannjjm 1998 4 histologically histologically RB cord-023095-4dannjjm 1998 5 ( ( -LRB- cord-023095-4dannjjm 1998 6 7 7 CD cord-023095-4dannjjm 1998 7 dogs dog NNS cord-023095-4dannjjm 1998 8 ) ) -RRB- cord-023095-4dannjjm 1998 9 or or CC cord-023095-4dannjjm 1998 10 cytologically cytologically NN cord-023095-4dannjjm 1998 11 ( ( -LRB- cord-023095-4dannjjm 1998 12 1 1 CD cord-023095-4dannjjm 1998 13 dog dog NN cord-023095-4dannjjm 1998 14 ) ) -RRB- cord-023095-4dannjjm 1998 15 . . . cord-023095-4dannjjm 1999 1 Cortical cortical JJ cord-023095-4dannjjm 1999 2 tumors tumor NNS cord-023095-4dannjjm 1999 3 were be VBD cord-023095-4dannjjm 1999 4 diagnosed diagnose VBN cord-023095-4dannjjm 1999 5 histologically histologically RB cord-023095-4dannjjm 1999 6 ( ( -LRB- cord-023095-4dannjjm 1999 7 9 9 CD cord-023095-4dannjjm 1999 8 dogs dog NNS cord-023095-4dannjjm 1999 9 ) ) -RRB- cord-023095-4dannjjm 1999 10 or or CC cord-023095-4dannjjm 1999 11 by by IN cord-023095-4dannjjm 1999 12 response response NN cord-023095-4dannjjm 1999 13 to to IN cord-023095-4dannjjm 1999 14 trilostane trilostane NNP cord-023095-4dannjjm 1999 15 treatment treatment NN cord-023095-4dannjjm 1999 16 after after IN cord-023095-4dannjjm 1999 17 obtaining obtain VBG cord-023095-4dannjjm 1999 18 consistent consistent JJ cord-023095-4dannjjm 1999 19 endocrine endocrine JJ cord-023095-4dannjjm 1999 20 test test NN cord-023095-4dannjjm 1999 21 results result NNS cord-023095-4dannjjm 1999 22 ( ( -LRB- cord-023095-4dannjjm 1999 23 3 3 CD cord-023095-4dannjjm 1999 24 dogs dog NNS cord-023095-4dannjjm 1999 25 Occult occult JJ cord-023095-4dannjjm 1999 26 hyperadrenocorticism hyperadrenocorticism NN cord-023095-4dannjjm 1999 27 ( ( -LRB- cord-023095-4dannjjm 1999 28 HAC HAC NNP cord-023095-4dannjjm 1999 29 ) ) -RRB- cord-023095-4dannjjm 1999 30 has have VBZ cord-023095-4dannjjm 1999 31 been be VBN cord-023095-4dannjjm 1999 32 theorized theorize VBN cord-023095-4dannjjm 1999 33 to to TO cord-023095-4dannjjm 1999 34 exist exist VB cord-023095-4dannjjm 1999 35 in in IN cord-023095-4dannjjm 1999 36 which which WDT cord-023095-4dannjjm 1999 37 excess excess JJ cord-023095-4dannjjm 1999 38 adrenal adrenal JJ cord-023095-4dannjjm 1999 39 sex sex NN cord-023095-4dannjjm 1999 40 hormone hormone NN cord-023095-4dannjjm 1999 41 secretion secretion NN cord-023095-4dannjjm 1999 42 induces induce VBZ cord-023095-4dannjjm 1999 43 the the DT cord-023095-4dannjjm 1999 44 clinical clinical JJ cord-023095-4dannjjm 1999 45 signs sign NNS cord-023095-4dannjjm 1999 46 and and CC cord-023095-4dannjjm 1999 47 laboratory laboratory NN cord-023095-4dannjjm 1999 48 changes change NNS cord-023095-4dannjjm 1999 49 associated associate VBN cord-023095-4dannjjm 1999 50 with with IN cord-023095-4dannjjm 1999 51 classic classic JJ cord-023095-4dannjjm 1999 52 HAC HAC NNP cord-023095-4dannjjm 1999 53 . . . cord-023095-4dannjjm 2000 1 However however RB cord-023095-4dannjjm 2000 2 , , , cord-023095-4dannjjm 2000 3 the the DT cord-023095-4dannjjm 2000 4 ability ability NN cord-023095-4dannjjm 2000 5 of of IN cord-023095-4dannjjm 2000 6 sex sex NN cord-023095-4dannjjm 2000 7 hormones hormone NNS cord-023095-4dannjjm 2000 8 to to TO cord-023095-4dannjjm 2000 9 cause cause VB cord-023095-4dannjjm 2000 10 such such JJ cord-023095-4dannjjm 2000 11 alterations alteration NNS cord-023095-4dannjjm 2000 12 has have VBZ cord-023095-4dannjjm 2000 13 never never RB cord-023095-4dannjjm 2000 14 been be VBN cord-023095-4dannjjm 2000 15 closely closely RB cord-023095-4dannjjm 2000 16 evaluated evaluate VBN cord-023095-4dannjjm 2000 17 . . . cord-023095-4dannjjm 2001 1 If if IN cord-023095-4dannjjm 2001 2 sex sex NN cord-023095-4dannjjm 2001 3 hormones hormone NNS cord-023095-4dannjjm 2001 4 can can MD cord-023095-4dannjjm 2001 5 cause cause VB cord-023095-4dannjjm 2001 6 a a DT cord-023095-4dannjjm 2001 7 syndrome syndrome NN cord-023095-4dannjjm 2001 8 similar similar JJ cord-023095-4dannjjm 2001 9 to to IN cord-023095-4dannjjm 2001 10 classic classic JJ cord-023095-4dannjjm 2001 11 HAC HAC NNP cord-023095-4dannjjm 2001 12 , , , cord-023095-4dannjjm 2001 13 they -PRON- PRP cord-023095-4dannjjm 2001 14 should should MD cord-023095-4dannjjm 2001 15 be be VB cord-023095-4dannjjm 2001 16 able able JJ cord-023095-4dannjjm 2001 17 to to TO cord-023095-4dannjjm 2001 18 induce induce VB cord-023095-4dannjjm 2001 19 expression expression NN cord-023095-4dannjjm 2001 20 of of IN cord-023095-4dannjjm 2001 21 classic classic JJ cord-023095-4dannjjm 2001 22 glucocorticoid glucocorticoid NN cord-023095-4dannjjm 2001 23 - - HYPH cord-023095-4dannjjm 2001 24 induced induce VBN cord-023095-4dannjjm 2001 25 genes gene NNS cord-023095-4dannjjm 2001 26 . . . cord-023095-4dannjjm 2002 1 The the DT cord-023095-4dannjjm 2002 2 purpose purpose NN cord-023095-4dannjjm 2002 3 of of IN cord-023095-4dannjjm 2002 4 the the DT cord-023095-4dannjjm 2002 5 study study NN cord-023095-4dannjjm 2002 6 was be VBD cord-023095-4dannjjm 2002 7 to to TO cord-023095-4dannjjm 2002 8 determine determine VB cord-023095-4dannjjm 2002 9 if if IN cord-023095-4dannjjm 2002 10 in in FW cord-023095-4dannjjm 2002 11 vitro vitro FW cord-023095-4dannjjm 2002 12 expression expression NN cord-023095-4dannjjm 2002 13 of of IN cord-023095-4dannjjm 2002 14 the the DT cord-023095-4dannjjm 2002 15 gene gene NN cord-023095-4dannjjm 2002 16 for for IN cord-023095-4dannjjm 2002 17 corticosteroid corticosteroid NN cord-023095-4dannjjm 2002 18 - - HYPH cord-023095-4dannjjm 2002 19 induced induce VBN cord-023095-4dannjjm 2002 20 ALP ALP NNP cord-023095-4dannjjm 2002 21 ( ( -LRB- cord-023095-4dannjjm 2002 22 CIALP CIALP NNP cord-023095-4dannjjm 2002 23 ) ) -RRB- cord-023095-4dannjjm 2002 24 could could MD cord-023095-4dannjjm 2002 25 be be VB cord-023095-4dannjjm 2002 26 induced induce VBN cord-023095-4dannjjm 2002 27 by by IN cord-023095-4dannjjm 2002 28 clinically clinically RB cord-023095-4dannjjm 2002 29 relevant relevant JJ cord-023095-4dannjjm 2002 30 concentrations concentration NNS cord-023095-4dannjjm 2002 31 of of IN cord-023095-4dannjjm 2002 32 cortisol cortisol NN cord-023095-4dannjjm 2002 33 and and CC cord-023095-4dannjjm 2002 34 sex sex NN cord-023095-4dannjjm 2002 35 hormones hormone NNS cord-023095-4dannjjm 2002 36 believed believe VBN cord-023095-4dannjjm 2002 37 to to TO cord-023095-4dannjjm 2002 38 cause cause VB cord-023095-4dannjjm 2002 39 occult occult JJ cord-023095-4dannjjm 2002 40 HAC HAC NNP cord-023095-4dannjjm 2002 41 . . . cord-023095-4dannjjm 2003 1 Canine canine JJ cord-023095-4dannjjm 2003 2 hepatocytes hepatocyte NNS cord-023095-4dannjjm 2003 3 were be VBD cord-023095-4dannjjm 2003 4 purchased purchase VBN cord-023095-4dannjjm 2003 5 from from IN cord-023095-4dannjjm 2003 6 a a DT cord-023095-4dannjjm 2003 7 commercial commercial JJ cord-023095-4dannjjm 2003 8 source source NN cord-023095-4dannjjm 2003 9 ( ( -LRB- cord-023095-4dannjjm 2003 10 CellzDirect CellzDirect NNP cord-023095-4dannjjm 2003 11 or or CC cord-023095-4dannjjm 2003 12 InVitro InVitro NNP cord-023095-4dannjjm 2003 13 ) ) -RRB- cord-023095-4dannjjm 2003 14 in in IN cord-023095-4dannjjm 2003 15 6-well 6-well CD cord-023095-4dannjjm 2003 16 plates plate NNS cord-023095-4dannjjm 2003 17 . . . cord-023095-4dannjjm 2004 1 Upon upon IN cord-023095-4dannjjm 2004 2 arrival arrival NN cord-023095-4dannjjm 2004 3 ( ( -LRB- cord-023095-4dannjjm 2004 4 3 3 CD cord-023095-4dannjjm 2004 5 - - SYM cord-023095-4dannjjm 2004 6 4 4 CD cord-023095-4dannjjm 2004 7 plates plate NNS cord-023095-4dannjjm 2004 8 per per IN cord-023095-4dannjjm 2004 9 shipment shipment NN cord-023095-4dannjjm 2004 10 ) ) -RRB- cord-023095-4dannjjm 2004 11 , , , cord-023095-4dannjjm 2004 12 the the DT cord-023095-4dannjjm 2004 13 cells cell NNS cord-023095-4dannjjm 2004 14 were be VBD cord-023095-4dannjjm 2004 15 allowed allow VBN cord-023095-4dannjjm 2004 16 to to TO cord-023095-4dannjjm 2004 17 recover recover VB cord-023095-4dannjjm 2004 18 in in IN cord-023095-4dannjjm 2004 19 general general JJ cord-023095-4dannjjm 2004 20 media medium NNS cord-023095-4dannjjm 2004 21 per per IN cord-023095-4dannjjm 2004 22 supplier supplier NN cord-023095-4dannjjm 2004 23 recommendations recommendation NNS cord-023095-4dannjjm 2004 24 . . . cord-023095-4dannjjm 2005 1 After after IN cord-023095-4dannjjm 2005 2 4 4 CD cord-023095-4dannjjm 2005 3 hrs hrs NN cord-023095-4dannjjm 2005 4 , , , cord-023095-4dannjjm 2005 5 media medium NNS cord-023095-4dannjjm 2005 6 was be VBD cord-023095-4dannjjm 2005 7 changed change VBN cord-023095-4dannjjm 2005 8 to to IN cord-023095-4dannjjm 2005 9 William William NNP cord-023095-4dannjjm 2005 10 's 's POS cord-023095-4dannjjm 2005 11 E e NN cord-023095-4dannjjm 2005 12 media medium NNS cord-023095-4dannjjm 2005 13 ( ( -LRB- cord-023095-4dannjjm 2005 14 -L -L : cord-023095-4dannjjm 2005 15 - - HYPH cord-023095-4dannjjm 2005 16 glutamine glutamine NN cord-023095-4dannjjm 2005 17 ) ) -RRB- cord-023095-4dannjjm 2005 18 containing contain VBG cord-023095-4dannjjm 2005 19 concentrations concentration NNS cord-023095-4dannjjm 2005 20 of of IN cord-023095-4dannjjm 2005 21 cortisol cortisol NN cord-023095-4dannjjm 2005 22 or or CC cord-023095-4dannjjm 2005 23 sex sex NN cord-023095-4dannjjm 2005 24 hormones hormone NNS cord-023095-4dannjjm 2005 25 that that WDT cord-023095-4dannjjm 2005 26 have have VBP cord-023095-4dannjjm 2005 27 been be VBN cord-023095-4dannjjm 2005 28 documented document VBN cord-023095-4dannjjm 2005 29 in in IN cord-023095-4dannjjm 2005 30 the the DT cord-023095-4dannjjm 2005 31 literature literature NN cord-023095-4dannjjm 2005 32 in in IN cord-023095-4dannjjm 2005 33 dogs dog NNS cord-023095-4dannjjm 2005 34 with with IN cord-023095-4dannjjm 2005 35 HAC HAC NNP cord-023095-4dannjjm 2005 36 or or CC cord-023095-4dannjjm 2005 37 with with IN cord-023095-4dannjjm 2005 38 purported purport VBN cord-023095-4dannjjm 2005 39 occult occult JJ cord-023095-4dannjjm 2005 40 HAC HAC NNP cord-023095-4dannjjm 2005 41 . . . cord-023095-4dannjjm 2006 1 Each each DT cord-023095-4dannjjm 2006 2 plate plate NN cord-023095-4dannjjm 2006 3 was be VBD cord-023095-4dannjjm 2006 4 treated treat VBN cord-023095-4dannjjm 2006 5 with with IN cord-023095-4dannjjm 2006 6 a a DT cord-023095-4dannjjm 2006 7 different different JJ cord-023095-4dannjjm 2006 8 hormone hormone NN cord-023095-4dannjjm 2006 9 ( ( -LRB- cord-023095-4dannjjm 2006 10 cortisol cortisol NN cord-023095-4dannjjm 2006 11 , , , cord-023095-4dannjjm 2006 12 17-hydroxyprogesterone 17-hydroxyprogesterone CD cord-023095-4dannjjm 2006 13 [ [ -LRB- cord-023095-4dannjjm 2006 14 17OHP 17ohp CD cord-023095-4dannjjm 2006 15 ] ] -RRB- cord-023095-4dannjjm 2006 16 , , , cord-023095-4dannjjm 2006 17 progesterone progesterone NN cord-023095-4dannjjm 2006 18 , , , cord-023095-4dannjjm 2006 19 estradiol estradiol NN cord-023095-4dannjjm 2006 20 or or CC cord-023095-4dannjjm 2006 21 androstenedione androstenedione NN cord-023095-4dannjjm 2006 22 ) ) -RRB- cord-023095-4dannjjm 2006 23 , , , cord-023095-4dannjjm 2006 24 and and CC cord-023095-4dannjjm 2006 25 each each DT cord-023095-4dannjjm 2006 26 well well NN cord-023095-4dannjjm 2006 27 contained contain VBD cord-023095-4dannjjm 2006 28 a a DT cord-023095-4dannjjm 2006 29 different different JJ cord-023095-4dannjjm 2006 30 concentration concentration NN cord-023095-4dannjjm 2006 31 ( ( -LRB- cord-023095-4dannjjm 2006 32 starting start VBG cord-023095-4dannjjm 2006 33 with with IN cord-023095-4dannjjm 2006 34 no no DT cord-023095-4dannjjm 2006 35 hormone hormone NN cord-023095-4dannjjm 2006 36 added add VBN cord-023095-4dannjjm 2006 37 as as IN cord-023095-4dannjjm 2006 38 a a DT cord-023095-4dannjjm 2006 39 negative negative JJ cord-023095-4dannjjm 2006 40 control control NN cord-023095-4dannjjm 2006 41 ) ) -RRB- cord-023095-4dannjjm 2006 42 to to TO cord-023095-4dannjjm 2006 43 evaluate evaluate VB cord-023095-4dannjjm 2006 44 a a DT cord-023095-4dannjjm 2006 45 dose dose JJ cord-023095-4dannjjm 2006 46 response response NN cord-023095-4dannjjm 2006 47 . . . cord-023095-4dannjjm 2007 1 Media Media NNP cord-023095-4dannjjm 2007 2 was be VBD cord-023095-4dannjjm 2007 3 changed change VBN cord-023095-4dannjjm 2007 4 daily daily RB cord-023095-4dannjjm 2007 5 . . . cord-023095-4dannjjm 2008 1 After after IN cord-023095-4dannjjm 2008 2 5 5 CD cord-023095-4dannjjm 2008 3 days day NNS cord-023095-4dannjjm 2008 4 of of IN cord-023095-4dannjjm 2008 5 hormone hormone NN cord-023095-4dannjjm 2008 6 exposure exposure NN cord-023095-4dannjjm 2008 7 , , , cord-023095-4dannjjm 2008 8 RNA RNA NNP cord-023095-4dannjjm 2008 9 was be VBD cord-023095-4dannjjm 2008 10 extracted extract VBN cord-023095-4dannjjm 2008 11 . . . cord-023095-4dannjjm 2009 1 Reverse reverse JJ cord-023095-4dannjjm 2009 2 transcription transcription NN cord-023095-4dannjjm 2009 3 was be VBD cord-023095-4dannjjm 2009 4 performed perform VBN cord-023095-4dannjjm 2009 5 and and CC cord-023095-4dannjjm 2009 6 the the DT cord-023095-4dannjjm 2009 7 product product NN cord-023095-4dannjjm 2009 8 used use VBN cord-023095-4dannjjm 2009 9 for for IN cord-023095-4dannjjm 2009 10 quantitative quantitative JJ cord-023095-4dannjjm 2009 11 PCR PCR NNP cord-023095-4dannjjm 2009 12 for for IN cord-023095-4dannjjm 2009 13 CIALP CIALP NNP cord-023095-4dannjjm 2009 14 and and CC cord-023095-4dannjjm 2009 15 beta beta NN cord-023095-4dannjjm 2009 16 - - HYPH cord-023095-4dannjjm 2009 17 actin actin JJ cord-023095-4dannjjm 2009 18 ( ( -LRB- cord-023095-4dannjjm 2009 19 Roche Roche NNP cord-023095-4dannjjm 2009 20 Lightcycler Lightcycler NNP cord-023095-4dannjjm 2009 21 ) ) -RRB- cord-023095-4dannjjm 2009 22 using use VBG cord-023095-4dannjjm 2009 23 a a DT cord-023095-4dannjjm 2009 24 gene gene NN cord-023095-4dannjjm 2009 25 - - HYPH cord-023095-4dannjjm 2009 26 specific specific JJ cord-023095-4dannjjm 2009 27 fluorescent fluorescent JJ cord-023095-4dannjjm 2009 28 probe probe NN cord-023095-4dannjjm 2009 29 for for IN cord-023095-4dannjjm 2009 30 detection detection NN cord-023095-4dannjjm 2009 31 . . . cord-023095-4dannjjm 2010 1 Standard standard JJ cord-023095-4dannjjm 2010 2 curves curve NNS cord-023095-4dannjjm 2010 3 were be VBD cord-023095-4dannjjm 2010 4 created create VBN cord-023095-4dannjjm 2010 5 for for IN cord-023095-4dannjjm 2010 6 each each DT cord-023095-4dannjjm 2010 7 gene gene NN cord-023095-4dannjjm 2010 8 . . . cord-023095-4dannjjm 2011 1 All all DT cord-023095-4dannjjm 2011 2 samples sample NNS cord-023095-4dannjjm 2011 3 and and CC cord-023095-4dannjjm 2011 4 standards standard NNS cord-023095-4dannjjm 2011 5 were be VBD cord-023095-4dannjjm 2011 6 run run VBN cord-023095-4dannjjm 2011 7 in in IN cord-023095-4dannjjm 2011 8 duplicate duplicate NN cord-023095-4dannjjm 2011 9 . . . cord-023095-4dannjjm 2012 1 Using use VBG cord-023095-4dannjjm 2012 2 the the DT cord-023095-4dannjjm 2012 3 Lightcycler Lightcycler NNP cord-023095-4dannjjm 2012 4 software software NN cord-023095-4dannjjm 2012 5 ( ( -LRB- cord-023095-4dannjjm 2012 6 vers vers NNP cord-023095-4dannjjm 2012 7 4.0 4.0 CD cord-023095-4dannjjm 2012 8 ) ) -RRB- cord-023095-4dannjjm 2012 9 , , , cord-023095-4dannjjm 2012 10 CIALP CIALP NNP cord-023095-4dannjjm 2012 11 expression expression NN cord-023095-4dannjjm 2012 12 was be VBD cord-023095-4dannjjm 2012 13 normalized normalize VBN cord-023095-4dannjjm 2012 14 to to IN cord-023095-4dannjjm 2012 15 that that DT cord-023095-4dannjjm 2012 16 of of IN cord-023095-4dannjjm 2012 17 beta beta NN cord-023095-4dannjjm 2012 18 - - HYPH cord-023095-4dannjjm 2012 19 actin actin JJ cord-023095-4dannjjm 2012 20 . . . cord-023095-4dannjjm 2013 1 Fold fold VB cord-023095-4dannjjm 2013 2 change change NN cord-023095-4dannjjm 2013 3 in in IN cord-023095-4dannjjm 2013 4 expression expression NN cord-023095-4dannjjm 2013 5 was be VBD cord-023095-4dannjjm 2013 6 determined determine VBN cord-023095-4dannjjm 2013 7 relative relative JJ cord-023095-4dannjjm 2013 8 to to IN cord-023095-4dannjjm 2013 9 the the DT cord-023095-4dannjjm 2013 10 negative negative JJ cord-023095-4dannjjm 2013 11 control control NN cord-023095-4dannjjm 2013 12 . . . cord-023095-4dannjjm 2014 1 Each each DT cord-023095-4dannjjm 2014 2 sex sex NN cord-023095-4dannjjm 2014 3 hormone hormone NN cord-023095-4dannjjm 2014 4 was be VBD cord-023095-4dannjjm 2014 5 used use VBN cord-023095-4dannjjm 2014 6 to to TO cord-023095-4dannjjm 2014 7 treat treat VB cord-023095-4dannjjm 2014 8 3 3 CD cord-023095-4dannjjm 2014 9 plates plate NNS cord-023095-4dannjjm 2014 10 ; ; : cord-023095-4dannjjm 2014 11 one one CD cord-023095-4dannjjm 2014 12 plate plate NN cord-023095-4dannjjm 2014 13 in in IN cord-023095-4dannjjm 2014 14 each each DT cord-023095-4dannjjm 2014 15 shipment shipment NN cord-023095-4dannjjm 2014 16 was be VBD cord-023095-4dannjjm 2014 17 treated treat VBN cord-023095-4dannjjm 2014 18 with with IN cord-023095-4dannjjm 2014 19 cortisol cortisol NN cord-023095-4dannjjm 2014 20 as as IN cord-023095-4dannjjm 2014 21 a a DT cord-023095-4dannjjm 2014 22 positive positive JJ cord-023095-4dannjjm 2014 23 control control NN cord-023095-4dannjjm 2014 24 . . . cord-023095-4dannjjm 2015 1 For for IN cord-023095-4dannjjm 2015 2 cortisol cortisol NN cord-023095-4dannjjm 2015 3 , , , cord-023095-4dannjjm 2015 4 a a DT cord-023095-4dannjjm 2015 5 dose dose JJ cord-023095-4dannjjm 2015 6 response response NN cord-023095-4dannjjm 2015 7 was be VBD cord-023095-4dannjjm 2015 8 seen see VBN cord-023095-4dannjjm 2015 9 in in IN cord-023095-4dannjjm 2015 10 expression expression NN cord-023095-4dannjjm 2015 11 of of IN cord-023095-4dannjjm 2015 12 the the DT cord-023095-4dannjjm 2015 13 CIALP CIALP NNP cord-023095-4dannjjm 2015 14 gene gene NN cord-023095-4dannjjm 2015 15 . . . cord-023095-4dannjjm 2016 1 Compared compare VBN cord-023095-4dannjjm 2016 2 to to IN cord-023095-4dannjjm 2016 3 no no DT cord-023095-4dannjjm 2016 4 cortisol cortisol NN cord-023095-4dannjjm 2016 5 , , , cord-023095-4dannjjm 2016 6 10 10 CD cord-023095-4dannjjm 2016 7 , , , cord-023095-4dannjjm 2016 8 50 50 CD cord-023095-4dannjjm 2016 9 , , , cord-023095-4dannjjm 2016 10 100 100 CD cord-023095-4dannjjm 2016 11 , , , cord-023095-4dannjjm 2016 12 150 150 CD cord-023095-4dannjjm 2016 13 , , , cord-023095-4dannjjm 2016 14 250 250 CD cord-023095-4dannjjm 2016 15 and and CC cord-023095-4dannjjm 2016 16 500 500 CD cord-023095-4dannjjm 2016 17 nmol nmol JJ cord-023095-4dannjjm 2016 18 cortisol cortisol NN cord-023095-4dannjjm 2016 19 increased increase VBN cord-023095-4dannjjm 2016 20 expression expression NN cord-023095-4dannjjm 2016 21 2.8 2.8 CD cord-023095-4dannjjm 2016 22 , , , cord-023095-4dannjjm 2016 23 4.6 4.6 CD cord-023095-4dannjjm 2016 24 , , , cord-023095-4dannjjm 2016 25 7.1 7.1 CD cord-023095-4dannjjm 2016 26 . . . cord-023095-4dannjjm 2016 27 9.3 9.3 CD cord-023095-4dannjjm 2016 28 , , , cord-023095-4dannjjm 2016 29 9.9 9.9 CD cord-023095-4dannjjm 2016 30 and and CC cord-023095-4dannjjm 2016 31 9.8 9.8 CD cord-023095-4dannjjm 2016 32 fold fold NN cord-023095-4dannjjm 2016 33 , , , cord-023095-4dannjjm 2016 34 respectively respectively RB cord-023095-4dannjjm 2016 35 . . . cord-023095-4dannjjm 2017 1 A a DT cord-023095-4dannjjm 2017 2 2-fold 2-fold CD cord-023095-4dannjjm 2017 3 increase increase NN cord-023095-4dannjjm 2017 4 is be VBZ cord-023095-4dannjjm 2017 5 considered consider VBN cord-023095-4dannjjm 2017 6 significant significant JJ cord-023095-4dannjjm 2017 7 ( ( -LRB- cord-023095-4dannjjm 2017 8 J.Vandesompele J.Vandesompele NNP cord-023095-4dannjjm 2017 9 et et NNP cord-023095-4dannjjm 2017 10 al al NNP cord-023095-4dannjjm 2017 11 Genome Genome NNP cord-023095-4dannjjm 2017 12 Biol Biol NNP cord-023095-4dannjjm 2017 13 2002 2002 CD cord-023095-4dannjjm 2017 14 ) ) -RRB- cord-023095-4dannjjm 2017 15 . . . cord-023095-4dannjjm 2018 1 Expression expression NN cord-023095-4dannjjm 2018 2 of of IN cord-023095-4dannjjm 2018 3 CIALP CIALP NNP cord-023095-4dannjjm 2018 4 was be VBD cord-023095-4dannjjm 2018 5 not not RB cord-023095-4dannjjm 2018 6 significantly significantly RB cord-023095-4dannjjm 2018 7 induced induce VBN cord-023095-4dannjjm 2018 8 in in IN cord-023095-4dannjjm 2018 9 response response NN cord-023095-4dannjjm 2018 10 to to IN cord-023095-4dannjjm 2018 11 any any DT cord-023095-4dannjjm 2018 12 concentration concentration NN cord-023095-4dannjjm 2018 13 of of IN cord-023095-4dannjjm 2018 14 17OHP 17ohp CD cord-023095-4dannjjm 2018 15 ( ( -LRB- cord-023095-4dannjjm 2018 16 10 10 CD cord-023095-4dannjjm 2018 17 nM nm NN cord-023095-4dannjjm 2018 18 maximum maximum NN cord-023095-4dannjjm 2018 19 ) ) -RRB- cord-023095-4dannjjm 2018 20 , , , cord-023095-4dannjjm 2018 21 progesterone progesterone NN cord-023095-4dannjjm 2018 22 ( ( -LRB- cord-023095-4dannjjm 2018 23 5 5 CD cord-023095-4dannjjm 2018 24 nM nm NN cord-023095-4dannjjm 2018 25 maximum maximum NN cord-023095-4dannjjm 2018 26 ) ) -RRB- cord-023095-4dannjjm 2018 27 , , , cord-023095-4dannjjm 2018 28 estradiol estradiol FW cord-023095-4dannjjm 2018 29 ( ( -LRB- cord-023095-4dannjjm 2018 30 max max NNP cord-023095-4dannjjm 2018 31 400 400 CD cord-023095-4dannjjm 2018 32 pM pm NN cord-023095-4dannjjm 2018 33 maximum maximum NN cord-023095-4dannjjm 2018 34 ) ) -RRB- cord-023095-4dannjjm 2018 35 or or CC cord-023095-4dannjjm 2018 36 androstenedione androstenedione NN cord-023095-4dannjjm 2018 37 ( ( -LRB- cord-023095-4dannjjm 2018 38 100 100 CD cord-023095-4dannjjm 2018 39 nM nm CD cord-023095-4dannjjm 2018 40 maximum maximum NN cord-023095-4dannjjm 2018 41 ) ) -RRB- cord-023095-4dannjjm 2018 42 . . . cord-023095-4dannjjm 2019 1 We -PRON- PRP cord-023095-4dannjjm 2019 2 conclude conclude VBP cord-023095-4dannjjm 2019 3 that that IN cord-023095-4dannjjm 2019 4 in in IN cord-023095-4dannjjm 2019 5 vitro vitro FW cord-023095-4dannjjm 2019 6 these these DT cord-023095-4dannjjm 2019 7 sex sex NN cord-023095-4dannjjm 2019 8 hormones hormone NNS cord-023095-4dannjjm 2019 9 do do VBP cord-023095-4dannjjm 2019 10 not not RB cord-023095-4dannjjm 2019 11 induce induce VB cord-023095-4dannjjm 2019 12 expression expression NN cord-023095-4dannjjm 2019 13 of of IN cord-023095-4dannjjm 2019 14 the the DT cord-023095-4dannjjm 2019 15 CIALP CIALP NNP cord-023095-4dannjjm 2019 16 gene gene NN cord-023095-4dannjjm 2019 17 which which WDT cord-023095-4dannjjm 2019 18 is be VBZ cord-023095-4dannjjm 2019 19 classically classically RB cord-023095-4dannjjm 2019 20 induced induce VBN cord-023095-4dannjjm 2019 21 by by IN cord-023095-4dannjjm 2019 22 cortisol cortisol NN cord-023095-4dannjjm 2019 23 in in IN cord-023095-4dannjjm 2019 24 vivo vivo NN cord-023095-4dannjjm 2019 25 ; ; : cord-023095-4dannjjm 2019 26 indeed indeed RB cord-023095-4dannjjm 2019 27 , , , cord-023095-4dannjjm 2019 28 elevated elevated JJ cord-023095-4dannjjm 2019 29 serum serum NN cord-023095-4dannjjm 2019 30 CIALP CIALP NNP cord-023095-4dannjjm 2019 31 activity activity NN cord-023095-4dannjjm 2019 32 is be VBZ cord-023095-4dannjjm 2019 33 a a DT cord-023095-4dannjjm 2019 34 hallmark hallmark NN cord-023095-4dannjjm 2019 35 of of IN cord-023095-4dannjjm 2019 36 classic classic JJ cord-023095-4dannjjm 2019 37 HAC HAC NNP cord-023095-4dannjjm 2019 38 . . . cord-023095-4dannjjm 2020 1 Thus thus RB cord-023095-4dannjjm 2020 2 , , , cord-023095-4dannjjm 2020 3 the the DT cord-023095-4dannjjm 2020 4 ability ability NN cord-023095-4dannjjm 2020 5 of of IN cord-023095-4dannjjm 2020 6 the the DT cord-023095-4dannjjm 2020 7 sex sex NN cord-023095-4dannjjm 2020 8 hormones hormone NNS cord-023095-4dannjjm 2020 9 to to TO cord-023095-4dannjjm 2020 10 induce induce VB cord-023095-4dannjjm 2020 11 the the DT cord-023095-4dannjjm 2020 12 gene gene NN cord-023095-4dannjjm 2020 13 in in IN cord-023095-4dannjjm 2020 14 vivo vivo NN cord-023095-4dannjjm 2020 15 must must MD cord-023095-4dannjjm 2020 16 be be VB cord-023095-4dannjjm 2020 17 questioned question VBN cord-023095-4dannjjm 2020 18 and and CC cord-023095-4dannjjm 2020 19 evaluated evaluate VBN cord-023095-4dannjjm 2020 20 . . . cord-023095-4dannjjm 2021 1 Measurement measurement NN cord-023095-4dannjjm 2021 2 of of IN cord-023095-4dannjjm 2021 3 sex sex NN cord-023095-4dannjjm 2021 4 hormones hormone NNS cord-023095-4dannjjm 2021 5 has have VBZ cord-023095-4dannjjm 2021 6 been be VBN cord-023095-4dannjjm 2021 7 advocated advocate VBN cord-023095-4dannjjm 2021 8 as as IN cord-023095-4dannjjm 2021 9 an an DT cord-023095-4dannjjm 2021 10 adjunct adjunct NN cord-023095-4dannjjm 2021 11 means mean VBZ cord-023095-4dannjjm 2021 12 for for IN cord-023095-4dannjjm 2021 13 diagnosing diagnose VBG cord-023095-4dannjjm 2021 14 typical typical JJ cord-023095-4dannjjm 2021 15 hyperadrenocorticism hyperadrenocorticism NN cord-023095-4dannjjm 2021 16 ( ( -LRB- cord-023095-4dannjjm 2021 17 HAC HAC NNP cord-023095-4dannjjm 2021 18 ) ) -RRB- cord-023095-4dannjjm 2021 19 , , , cord-023095-4dannjjm 2021 20 i.e. i.e. FW cord-023095-4dannjjm 2021 21 disease disease NN cord-023095-4dannjjm 2021 22 due due JJ cord-023095-4dannjjm 2021 23 to to IN cord-023095-4dannjjm 2021 24 excess excess JJ cord-023095-4dannjjm 2021 25 cortisol cortisol NN cord-023095-4dannjjm 2021 26 secretion secretion NN cord-023095-4dannjjm 2021 27 , , , cord-023095-4dannjjm 2021 28 as as RB cord-023095-4dannjjm 2021 29 well well RB cord-023095-4dannjjm 2021 30 as as IN cord-023095-4dannjjm 2021 31 for for IN cord-023095-4dannjjm 2021 32 diagnosis diagnosis NN cord-023095-4dannjjm 2021 33 of of IN cord-023095-4dannjjm 2021 34 atypical atypical JJ cord-023095-4dannjjm 2021 35 HAC HAC NNP cord-023095-4dannjjm 2021 36 , , , cord-023095-4dannjjm 2021 37 i.e. i.e. FW cord-023095-4dannjjm 2021 38 disease disease NN cord-023095-4dannjjm 2021 39 due due JJ cord-023095-4dannjjm 2021 40 to to IN cord-023095-4dannjjm 2021 41 excess excess JJ cord-023095-4dannjjm 2021 42 adrenal adrenal JJ cord-023095-4dannjjm 2021 43 sex sex NN cord-023095-4dannjjm 2021 44 hormone hormone NN cord-023095-4dannjjm 2021 45 secretion secretion NN cord-023095-4dannjjm 2021 46 . . . cord-023095-4dannjjm 2022 1 However however RB cord-023095-4dannjjm 2022 2 , , , cord-023095-4dannjjm 2022 3 measurements measurement NNS cord-023095-4dannjjm 2022 4 in in IN cord-023095-4dannjjm 2022 5 either either DT cord-023095-4dannjjm 2022 6 setting setting NN cord-023095-4dannjjm 2022 7 have have VBP cord-023095-4dannjjm 2022 8 not not RB cord-023095-4dannjjm 2022 9 been be VBN cord-023095-4dannjjm 2022 10 widely widely RB cord-023095-4dannjjm 2022 11 studied study VBN cord-023095-4dannjjm 2022 12 . . . cord-023095-4dannjjm 2023 1 Therefore therefore RB cord-023095-4dannjjm 2023 2 , , , cord-023095-4dannjjm 2023 3 our -PRON- PRP$ cord-023095-4dannjjm 2023 4 objectives objective NNS cord-023095-4dannjjm 2023 5 were be VBD cord-023095-4dannjjm 2023 6 : : : cord-023095-4dannjjm 2023 7 1 1 CD cord-023095-4dannjjm 2023 8 . . . cord-023095-4dannjjm 2024 1 To to TO cord-023095-4dannjjm 2024 2 determine determine VB cord-023095-4dannjjm 2024 3 the the DT cord-023095-4dannjjm 2024 4 sensitivity sensitivity NN cord-023095-4dannjjm 2024 5 of of IN cord-023095-4dannjjm 2024 6 17-hydroxy 17-hydroxy CD cord-023095-4dannjjm 2024 7 - - HYPH cord-023095-4dannjjm 2024 8 progesterone progesterone NN cord-023095-4dannjjm 2024 9 ( ( -LRB- cord-023095-4dannjjm 2024 10 17OHP 17ohp CD cord-023095-4dannjjm 2024 11 ) ) -RRB- cord-023095-4dannjjm 2024 12 and and CC cord-023095-4dannjjm 2024 13 estradiol estradiol NN cord-023095-4dannjjm 2024 14 concentrations concentration NNS cord-023095-4dannjjm 2024 15 pre pre VBP cord-023095-4dannjjm 2024 16 - - JJ cord-023095-4dannjjm 2024 17 and and CC cord-023095-4dannjjm 2024 18 post post JJ cord-023095-4dannjjm 2024 19 - - JJ cord-023095-4dannjjm 2024 20 ACTH ACTH NNP cord-023095-4dannjjm 2024 21 for for IN cord-023095-4dannjjm 2024 22 diagnosis diagnosis NN cord-023095-4dannjjm 2024 23 of of IN cord-023095-4dannjjm 2024 24 typical typical JJ cord-023095-4dannjjm 2024 25 HAC HAC NNP cord-023095-4dannjjm 2024 26 . . . cord-023095-4dannjjm 2025 1 2 2 LS cord-023095-4dannjjm 2025 2 . . . cord-023095-4dannjjm 2026 1 To to TO cord-023095-4dannjjm 2026 2 determine determine VB cord-023095-4dannjjm 2026 3 the the DT cord-023095-4dannjjm 2026 4 specificity specificity NN cord-023095-4dannjjm 2026 5 of of IN cord-023095-4dannjjm 2026 6 17OHP 17ohp CD cord-023095-4dannjjm 2026 7 and and CC cord-023095-4dannjjm 2026 8 estradiol estradiol NN cord-023095-4dannjjm 2026 9 concentrations concentration NNS cord-023095-4dannjjm 2026 10 preand preand NNP cord-023095-4dannjjm 2026 11 post post JJ cord-023095-4dannjjm 2026 12 - - JJ cord-023095-4dannjjm 2026 13 ACTH ACTH NNP cord-023095-4dannjjm 2026 14 for for IN cord-023095-4dannjjm 2026 15 diagnosis diagnosis NN cord-023095-4dannjjm 2026 16 of of IN cord-023095-4dannjjm 2026 17 occult occult JJ cord-023095-4dannjjm 2026 18 HAC HAC NNP cord-023095-4dannjjm 2026 19 . . . cord-023095-4dannjjm 2027 1 Dogs dog NNS cord-023095-4dannjjm 2027 2 that that WDT cord-023095-4dannjjm 2027 3 had have VBD cord-023095-4dannjjm 2027 4 PDH PDH NNP cord-023095-4dannjjm 2027 5 ( ( -LRB- cord-023095-4dannjjm 2027 6 n n NN cord-023095-4dannjjm 2027 7 5 5 CD cord-023095-4dannjjm 2027 8 12 12 CD cord-023095-4dannjjm 2027 9 ) ) -RRB- cord-023095-4dannjjm 2027 10 , , , cord-023095-4dannjjm 2027 11 dogs dog NNS cord-023095-4dannjjm 2027 12 that that WDT cord-023095-4dannjjm 2027 13 were be VBD cord-023095-4dannjjm 2027 14 suspected suspect VBN cord-023095-4dannjjm 2027 15 to to TO cord-023095-4dannjjm 2027 16 have have VB cord-023095-4dannjjm 2027 17 HAC HAC NNP cord-023095-4dannjjm 2027 18 but but CC cord-023095-4dannjjm 2027 19 proven prove VBN cord-023095-4dannjjm 2027 20 not not RB cord-023095-4dannjjm 2027 21 to to IN cord-023095-4dannjjm 2027 22 ( ( -LRB- cord-023095-4dannjjm 2027 23 had have VBD cord-023095-4dannjjm 2027 24 non non JJ cord-023095-4dannjjm 2027 25 - - JJ cord-023095-4dannjjm 2027 26 adrenal adrenal JJ cord-023095-4dannjjm 2027 27 illness illness NN cord-023095-4dannjjm 2027 28 [ [ -LRB- cord-023095-4dannjjm 2027 29 NAI NAI NNP cord-023095-4dannjjm 2027 30 , , , cord-023095-4dannjjm 2027 31 n n NN cord-023095-4dannjjm 2027 32 5 5 CD cord-023095-4dannjjm 2027 33 89 89 CD cord-023095-4dannjjm 2027 34 ] ] -RRB- cord-023095-4dannjjm 2027 35 ) ) -RRB- cord-023095-4dannjjm 2027 36 or or CC cord-023095-4dannjjm 2027 37 dogs dog NNS cord-023095-4dannjjm 2027 38 that that WDT cord-023095-4dannjjm 2027 39 were be VBD cord-023095-4dannjjm 2027 40 healthy healthy JJ cord-023095-4dannjjm 2027 41 ( ( -LRB- cord-023095-4dannjjm 2027 42 n n NN cord-023095-4dannjjm 2027 43 5 5 CD cord-023095-4dannjjm 2027 44 20 20 CD cord-023095-4dannjjm 2027 45 , , , cord-023095-4dannjjm 2027 46 used use VBN cord-023095-4dannjjm 2027 47 to to TO cord-023095-4dannjjm 2027 48 establish establish VB cord-023095-4dannjjm 2027 49 reference reference NN cord-023095-4dannjjm 2027 50 ranges range NNS cord-023095-4dannjjm 2027 51 [ [ -LRB- cord-023095-4dannjjm 2027 52 RR RR NNP cord-023095-4dannjjm 2027 53 ] ] -RRB- cord-023095-4dannjjm 2027 54 ) ) -RRB- cord-023095-4dannjjm 2027 55 were be VBD cord-023095-4dannjjm 2027 56 enrolled enrol VBN cord-023095-4dannjjm 2027 57 . . . cord-023095-4dannjjm 2028 1 ACTH ACTH NNP cord-023095-4dannjjm 2028 2 stimulation stimulation NN cord-023095-4dannjjm 2028 3 tests test NNS cord-023095-4dannjjm 2028 4 were be VBD cord-023095-4dannjjm 2028 5 performed perform VBN cord-023095-4dannjjm 2028 6 ( ( -LRB- cord-023095-4dannjjm 2028 7 5 5 CD cord-023095-4dannjjm 2028 8 mcg mcg NNP cord-023095-4dannjjm 2028 9 / / SYM cord-023095-4dannjjm 2028 10 kg kg NNP cord-023095-4dannjjm 2028 11 cosyntropin cosyntropin NNP cord-023095-4dannjjm 2028 12 IV IV NNP cord-023095-4dannjjm 2028 13 ) ) -RRB- cord-023095-4dannjjm 2028 14 ; ; : cord-023095-4dannjjm 2028 15 blood blood NN cord-023095-4dannjjm 2028 16 samples sample NNS cord-023095-4dannjjm 2028 17 were be VBD cord-023095-4dannjjm 2028 18 drawn draw VBN cord-023095-4dannjjm 2028 19 pre pre JJ cord-023095-4dannjjm 2028 20 and and CC cord-023095-4dannjjm 2028 21 60min 60min JJ cord-023095-4dannjjm 2028 22 post post NN cord-023095-4dannjjm 2028 23 ; ; : cord-023095-4dannjjm 2028 24 17OHP 17ohp CD cord-023095-4dannjjm 2028 25 and and CC cord-023095-4dannjjm 2028 26 estradiol estradiol NN cord-023095-4dannjjm 2028 27 were be VBD cord-023095-4dannjjm 2028 28 measured measure VBN cord-023095-4dannjjm 2028 29 by by IN cord-023095-4dannjjm 2028 30 previously previously RB cord-023095-4dannjjm 2028 31 validated validate VBN cord-023095-4dannjjm 2028 32 radioimmunoassays radioimmunoassay NNS cord-023095-4dannjjm 2028 33 . . . cord-023095-4dannjjm 2029 1 A a DT cord-023095-4dannjjm 2029 2 Kruskal Kruskal NNP cord-023095-4dannjjm 2029 3 - - HYPH cord-023095-4dannjjm 2029 4 Wallis Wallis NNP cord-023095-4dannjjm 2029 5 Rank Rank NNP cord-023095-4dannjjm 2029 6 Sum Sum NNP cord-023095-4dannjjm 2029 7 test test NN cord-023095-4dannjjm 2029 8 was be VBD cord-023095-4dannjjm 2029 9 used use VBN cord-023095-4dannjjm 2029 10 to to TO cord-023095-4dannjjm 2029 11 compare compare VB cord-023095-4dannjjm 2029 12 values value NNS cord-023095-4dannjjm 2029 13 between between IN cord-023095-4dannjjm 2029 14 the the DT cord-023095-4dannjjm 2029 15 groups group NNS cord-023095-4dannjjm 2029 16 . . . cord-023095-4dannjjm 2030 1 Significance significance NN cord-023095-4dannjjm 2030 2 was be VBD cord-023095-4dannjjm 2030 3 set set VBN cord-023095-4dannjjm 2030 4 at at IN cord-023095-4dannjjm 2030 5 p p NN cord-023095-4dannjjm 2030 6 o o NN cord-023095-4dannjjm 2030 7 0.05 0.05 CD cord-023095-4dannjjm 2030 8 . . . cord-023095-4dannjjm 2031 1 For for IN cord-023095-4dannjjm 2031 2 basal basal NN cord-023095-4dannjjm 2031 3 and and CC cord-023095-4dannjjm 2031 4 ACTH ACTH NNP cord-023095-4dannjjm 2031 5 - - HYPH cord-023095-4dannjjm 2031 6 stimulated stimulate VBN cord-023095-4dannjjm 2031 7 17OHP 17ohp CD cord-023095-4dannjjm 2031 8 concentrations concentration NNS cord-023095-4dannjjm 2031 9 , , , cord-023095-4dannjjm 2031 10 the the DT cord-023095-4dannjjm 2031 11 RR rr NN cord-023095-4dannjjm 2031 12 were be VBD cord-023095-4dannjjm 2031 13 determined determine VBN cord-023095-4dannjjm 2031 14 to to TO cord-023095-4dannjjm 2031 15 be be VB cord-023095-4dannjjm 2031 16 0.03 0.03 CD cord-023095-4dannjjm 2031 17 - - SYM cord-023095-4dannjjm 2031 18 0.6 0.6 CD cord-023095-4dannjjm 2031 19 ng ng NN cord-023095-4dannjjm 2031 20 / / SYM cord-023095-4dannjjm 2031 21 mL ml NN cord-023095-4dannjjm 2032 1 ( ( -LRB- cord-023095-4dannjjm 2032 2 mean mean VB cord-023095-4dannjjm 2032 3 AE AE NNP cord-023095-4dannjjm 2032 4 2 2 CD cord-023095-4dannjjm 2032 5 s.d s.d NNP cord-023095-4dannjjm 2032 6 . . NNP cord-023095-4dannjjm 2032 7 ; ; : cord-023095-4dannjjm 2032 8 range range VBP cord-023095-4dannjjm 2032 9 0.03 0.03 CD cord-023095-4dannjjm 2032 10 - - HYPH cord-023095-4dannjjm 2032 11 0.55 0.55 CD cord-023095-4dannjjm 2032 12 ) ) -RRB- cord-023095-4dannjjm 2032 13 and and CC cord-023095-4dannjjm 2032 14 0.3 0.3 CD cord-023095-4dannjjm 2032 15 - - SYM cord-023095-4dannjjm 2032 16 2.2 2.2 CD cord-023095-4dannjjm 2032 17 ng ng NN cord-023095-4dannjjm 2032 18 / / SYM cord-023095-4dannjjm 2032 19 mL ml NN cord-023095-4dannjjm 2033 1 ( ( -LRB- cord-023095-4dannjjm 2033 2 range range VBP cord-023095-4dannjjm 2033 3 0.31 0.31 CD cord-023095-4dannjjm 2033 4 - - SYM cord-023095-4dannjjm 2033 5 1.95 1.95 CD cord-023095-4dannjjm 2033 6 ) ) -RRB- cord-023095-4dannjjm 2033 7 , , , cord-023095-4dannjjm 2033 8 respectively respectively RB cord-023095-4dannjjm 2033 9 . . . cord-023095-4dannjjm 2034 1 In in IN cord-023095-4dannjjm 2034 2 PDH PDH NNP cord-023095-4dannjjm 2034 3 dogs dog NNS cord-023095-4dannjjm 2034 4 , , , cord-023095-4dannjjm 2034 5 3 3 CD cord-023095-4dannjjm 2034 6 and and CC cord-023095-4dannjjm 2034 7 7 7 CD cord-023095-4dannjjm 2034 8 had have VBD cord-023095-4dannjjm 2034 9 basal basal NN cord-023095-4dannjjm 2034 10 and and CC cord-023095-4dannjjm 2034 11 post post JJ cord-023095-4dannjjm 2034 12 - - JJ cord-023095-4dannjjm 2034 13 ACTH acth JJ cord-023095-4dannjjm 2034 14 17OHP 17ohp CD cord-023095-4dannjjm 2034 15 concentrations concentration NNS cord-023095-4dannjjm 2034 16 above above IN cord-023095-4dannjjm 2034 17 the the DT cord-023095-4dannjjm 2034 18 RR rr NN cord-023095-4dannjjm 2034 19 , , , cord-023095-4dannjjm 2034 20 respectively respectively RB cord-023095-4dannjjm 2034 21 ; ; : cord-023095-4dannjjm 2034 22 in in IN cord-023095-4dannjjm 2034 23 the the DT cord-023095-4dannjjm 2034 24 NAI NAI NNP cord-023095-4dannjjm 2034 25 group group NN cord-023095-4dannjjm 2034 26 , , , cord-023095-4dannjjm 2034 27 23 23 CD cord-023095-4dannjjm 2034 28 and and CC cord-023095-4dannjjm 2034 29 25 25 CD cord-023095-4dannjjm 2034 30 dogs dog NNS cord-023095-4dannjjm 2034 31 had have VBD cord-023095-4dannjjm 2034 32 concentrations concentration NNS cord-023095-4dannjjm 2034 33 above above IN cord-023095-4dannjjm 2034 34 the the DT cord-023095-4dannjjm 2034 35 RR rr NN cord-023095-4dannjjm 2034 36 , , , cord-023095-4dannjjm 2034 37 respectively respectively RB cord-023095-4dannjjm 2034 38 . . . cord-023095-4dannjjm 2035 1 Thus thus RB cord-023095-4dannjjm 2035 2 , , , cord-023095-4dannjjm 2035 3 the the DT cord-023095-4dannjjm 2035 4 sensitivity sensitivity NN cord-023095-4dannjjm 2035 5 of of IN cord-023095-4dannjjm 2035 6 basal basal NN cord-023095-4dannjjm 2035 7 and and CC cord-023095-4dannjjm 2035 8 post post JJ cord-023095-4dannjjm 2035 9 - - JJ cord-023095-4dannjjm 2035 10 ACTH ACTH NNP cord-023095-4dannjjm 2035 11 17OHP 17ohp CD cord-023095-4dannjjm 2035 12 measurement measurement NN cord-023095-4dannjjm 2035 13 for for IN cord-023095-4dannjjm 2035 14 diagnosis diagnosis NN cord-023095-4dannjjm 2035 15 of of IN cord-023095-4dannjjm 2035 16 HAC HAC NNP cord-023095-4dannjjm 2035 17 is be VBZ cord-023095-4dannjjm 2035 18 25 25 CD cord-023095-4dannjjm 2035 19 % % NN cord-023095-4dannjjm 2035 20 and and CC cord-023095-4dannjjm 2035 21 58 58 CD cord-023095-4dannjjm 2035 22 % % NN cord-023095-4dannjjm 2035 23 , , , cord-023095-4dannjjm 2035 24 respectively respectively RB cord-023095-4dannjjm 2035 25 . . . cord-023095-4dannjjm 2036 1 Specificity specificity NN cord-023095-4dannjjm 2036 2 of of IN cord-023095-4dannjjm 2036 3 diagnosis diagnosis NN cord-023095-4dannjjm 2036 4 is be VBZ cord-023095-4dannjjm 2036 5 72 72 CD cord-023095-4dannjjm 2036 6 % % NN cord-023095-4dannjjm 2036 7 and and CC cord-023095-4dannjjm 2036 8 74 74 CD cord-023095-4dannjjm 2036 9 % % NN cord-023095-4dannjjm 2036 10 , , , cord-023095-4dannjjm 2036 11 respectively respectively RB cord-023095-4dannjjm 2036 12 . . . cord-023095-4dannjjm 2037 1 Post post JJ cord-023095-4dannjjm 2037 2 - - JJ cord-023095-4dannjjm 2037 3 ACTH ACTH NNP cord-023095-4dannjjm 2037 4 17OHP 17ohp CD cord-023095-4dannjjm 2037 5 concentration concentration NN cord-023095-4dannjjm 2037 6 was be VBD cord-023095-4dannjjm 2037 7 significantly significantly RB cord-023095-4dannjjm 2037 8 different different JJ cord-023095-4dannjjm 2037 9 between between IN cord-023095-4dannjjm 2037 10 groups group NNS cord-023095-4dannjjm 2037 11 . . . cord-023095-4dannjjm 2038 1 For for IN cord-023095-4dannjjm 2038 2 basal basal NN cord-023095-4dannjjm 2038 3 and and CC cord-023095-4dannjjm 2038 4 stimulated stimulate VBN cord-023095-4dannjjm 2038 5 estradiol estradiol NN cord-023095-4dannjjm 2038 6 concentrations concentration NNS cord-023095-4dannjjm 2038 7 , , , cord-023095-4dannjjm 2038 8 the the DT cord-023095-4dannjjm 2038 9 RR rr NN cord-023095-4dannjjm 2038 10 were be VBD cord-023095-4dannjjm 2038 11 determined determine VBN cord-023095-4dannjjm 2038 12 to to TO cord-023095-4dannjjm 2038 13 be be VB cord-023095-4dannjjm 2038 14 81 81 CD cord-023095-4dannjjm 2038 15 - - SYM cord-023095-4dannjjm 2038 16 180 180 CD cord-023095-4dannjjm 2038 17 pg pg NN cord-023095-4dannjjm 2038 18 / / SYM cord-023095-4dannjjm 2038 19 mL ml NN cord-023095-4dannjjm 2038 20 ( ( -LRB- cord-023095-4dannjjm 2038 21 range range NNP cord-023095-4dannjjm 2038 22 89 89 CD cord-023095-4dannjjm 2038 23 - - SYM cord-023095-4dannjjm 2038 24 195 195 CD cord-023095-4dannjjm 2038 25 ) ) -RRB- cord-023095-4dannjjm 2038 26 and and CC cord-023095-4dannjjm 2038 27 71 71 CD cord-023095-4dannjjm 2038 28 - - SYM cord-023095-4dannjjm 2038 29 170 170 CD cord-023095-4dannjjm 2038 30 pg pg NN cord-023095-4dannjjm 2038 31 / / SYM cord-023095-4dannjjm 2038 32 mL ml NN cord-023095-4dannjjm 2038 33 ( ( -LRB- cord-023095-4dannjjm 2038 34 range range NNP cord-023095-4dannjjm 2038 35 74 74 CD cord-023095-4dannjjm 2038 36 - - SYM cord-023095-4dannjjm 2038 37 151 151 CD cord-023095-4dannjjm 2038 38 ) ) -RRB- cord-023095-4dannjjm 2038 39 , , , cord-023095-4dannjjm 2038 40 respectively respectively RB cord-023095-4dannjjm 2038 41 . . . cord-023095-4dannjjm 2039 1 For for IN cord-023095-4dannjjm 2039 2 both both DT cord-023095-4dannjjm 2039 3 basal basal NN cord-023095-4dannjjm 2039 4 and and CC cord-023095-4dannjjm 2039 5 stimulated stimulate VBD cord-023095-4dannjjm 2039 6 estradiol estradiol NN cord-023095-4dannjjm 2039 7 , , , cord-023095-4dannjjm 2039 8 4 4 CD cord-023095-4dannjjm 2039 9 PDH PDH NNP cord-023095-4dannjjm 2039 10 dogs dog NNS cord-023095-4dannjjm 2039 11 ( ( -LRB- cord-023095-4dannjjm 2039 12 n n NN cord-023095-4dannjjm 2039 13 5 5 CD cord-023095-4dannjjm 2039 14 9 9 CD cord-023095-4dannjjm 2039 15 ) ) -RRB- cord-023095-4dannjjm 2039 16 had have VBD cord-023095-4dannjjm 2039 17 concentrations concentration NNS cord-023095-4dannjjm 2039 18 above above IN cord-023095-4dannjjm 2039 19 the the DT cord-023095-4dannjjm 2039 20 RR rr NN cord-023095-4dannjjm 2039 21 ; ; : cord-023095-4dannjjm 2039 22 for for IN cord-023095-4dannjjm 2039 23 those those DT cord-023095-4dannjjm 2039 24 with with IN cord-023095-4dannjjm 2039 25 NAI NAI NNP cord-023095-4dannjjm 2039 26 ( ( -LRB- cord-023095-4dannjjm 2039 27 n n NN cord-023095-4dannjjm 2039 28 5 5 CD cord-023095-4dannjjm 2039 29 80 80 CD cord-023095-4dannjjm 2039 30 ) ) -RRB- cord-023095-4dannjjm 2039 31 , , , cord-023095-4dannjjm 2039 32 14 14 CD cord-023095-4dannjjm 2039 33 and and CC cord-023095-4dannjjm 2039 34 15 15 CD cord-023095-4dannjjm 2039 35 had have VBD cord-023095-4dannjjm 2039 36 concentrations concentration NNS cord-023095-4dannjjm 2039 37 above above IN cord-023095-4dannjjm 2039 38 the the DT cord-023095-4dannjjm 2039 39 RR rr NN cord-023095-4dannjjm 2039 40 , , , cord-023095-4dannjjm 2039 41 respectively respectively RB cord-023095-4dannjjm 2039 42 . . . cord-023095-4dannjjm 2040 1 Thus thus RB cord-023095-4dannjjm 2040 2 , , , cord-023095-4dannjjm 2040 3 the the DT cord-023095-4dannjjm 2040 4 sensitivity sensitivity NN cord-023095-4dannjjm 2040 5 of of IN cord-023095-4dannjjm 2040 6 estradiol estradiol NN cord-023095-4dannjjm 2040 7 measurement measurement NN cord-023095-4dannjjm 2040 8 for for IN cord-023095-4dannjjm 2040 9 diagnosis diagnosis NN cord-023095-4dannjjm 2040 10 of of IN cord-023095-4dannjjm 2040 11 HAC HAC NNP cord-023095-4dannjjm 2040 12 is be VBZ cord-023095-4dannjjm 2040 13 44 44 CD cord-023095-4dannjjm 2040 14 % % NN cord-023095-4dannjjm 2040 15 for for IN cord-023095-4dannjjm 2040 16 both both DT cord-023095-4dannjjm 2040 17 pre pre JJ cord-023095-4dannjjm 2040 18 - - JJ cord-023095-4dannjjm 2040 19 and and CC cord-023095-4dannjjm 2040 20 post post JJ cord-023095-4dannjjm 2040 21 - - JJ cord-023095-4dannjjm 2040 22 ACTH ACTH NNP cord-023095-4dannjjm 2040 23 . . . cord-023095-4dannjjm 2041 1 Specificity specificity NN cord-023095-4dannjjm 2041 2 of of IN cord-023095-4dannjjm 2041 3 estradiol estradiol NN cord-023095-4dannjjm 2041 4 for for IN cord-023095-4dannjjm 2041 5 diagnosis diagnosis NN cord-023095-4dannjjm 2041 6 for for IN cord-023095-4dannjjm 2041 7 HAC HAC NNP cord-023095-4dannjjm 2041 8 is be VBZ cord-023095-4dannjjm 2041 9 83 83 CD cord-023095-4dannjjm 2041 10 % % NN cord-023095-4dannjjm 2041 11 and and CC cord-023095-4dannjjm 2041 12 81 81 CD cord-023095-4dannjjm 2041 13 % % NN cord-023095-4dannjjm 2041 14 for for IN cord-023095-4dannjjm 2041 15 pre pre JJ cord-023095-4dannjjm 2041 16 - - JJ cord-023095-4dannjjm 2041 17 and and CC cord-023095-4dannjjm 2041 18 post post JJ cord-023095-4dannjjm 2041 19 - - JJ cord-023095-4dannjjm 2041 20 ACTH ACTH NNP cord-023095-4dannjjm 2041 21 , , , cord-023095-4dannjjm 2041 22 respectively respectively RB cord-023095-4dannjjm 2041 23 . . . cord-023095-4dannjjm 2042 1 Overall overall RB cord-023095-4dannjjm 2042 2 , , , cord-023095-4dannjjm 2042 3 23 23 CD cord-023095-4dannjjm 2042 4 dogs dog NNS cord-023095-4dannjjm 2042 5 with with IN cord-023095-4dannjjm 2042 6 NAI NAI NNP cord-023095-4dannjjm 2042 7 had have VBD cord-023095-4dannjjm 2042 8 at at RB cord-023095-4dannjjm 2042 9 least least RBS cord-023095-4dannjjm 2042 10 one one CD cord-023095-4dannjjm 2042 11 elevated elevate VBN cord-023095-4dannjjm 2042 12 estradiol estradiol NN cord-023095-4dannjjm 2042 13 concentration concentration NN cord-023095-4dannjjm 2042 14 ( ( -LRB- cord-023095-4dannjjm 2042 15 total total JJ cord-023095-4dannjjm 2042 16 specificity specificity NN cord-023095-4dannjjm 2042 17 70 70 CD cord-023095-4dannjjm 2042 18 % % NN cord-023095-4dannjjm 2042 19 ) ) -RRB- cord-023095-4dannjjm 2042 20 . . . cord-023095-4dannjjm 2043 1 Post post JJ cord-023095-4dannjjm 2043 2 - - JJ cord-023095-4dannjjm 2043 3 ACTH ACTH NNP cord-023095-4dannjjm 2043 4 estradiol estradiol NN cord-023095-4dannjjm 2043 5 concentration concentration NN cord-023095-4dannjjm 2043 6 was be VBD cord-023095-4dannjjm 2043 7 not not RB cord-023095-4dannjjm 2043 8 significantly significantly RB cord-023095-4dannjjm 2043 9 different different JJ cord-023095-4dannjjm 2043 10 between between IN cord-023095-4dannjjm 2043 11 groups group NNS cord-023095-4dannjjm 2043 12 . . . cord-023095-4dannjjm 2044 1 We -PRON- PRP cord-023095-4dannjjm 2044 2 conclude conclude VBP cord-023095-4dannjjm 2044 3 that that IN cord-023095-4dannjjm 2044 4 use use NN cord-023095-4dannjjm 2044 5 of of IN cord-023095-4dannjjm 2044 6 17OHP 17ohp CD cord-023095-4dannjjm 2044 7 and and CC cord-023095-4dannjjm 2044 8 estradiol estradiol NN cord-023095-4dannjjm 2044 9 concentrations concentration NNS cord-023095-4dannjjm 2044 10 for for IN cord-023095-4dannjjm 2044 11 diagnosis diagnosis NN cord-023095-4dannjjm 2044 12 of of IN cord-023095-4dannjjm 2044 13 HAC HAC NNP cord-023095-4dannjjm 2044 14 can can MD cord-023095-4dannjjm 2044 15 be be VB cord-023095-4dannjjm 2044 16 problematic problematic JJ cord-023095-4dannjjm 2044 17 . . . cord-023095-4dannjjm 2045 1 Sensitivity sensitivity NN cord-023095-4dannjjm 2045 2 and and CC cord-023095-4dannjjm 2045 3 specificity specificity NN cord-023095-4dannjjm 2045 4 are be VBP cord-023095-4dannjjm 2045 5 relatively relatively RB cord-023095-4dannjjm 2045 6 low low JJ cord-023095-4dannjjm 2045 7 , , , cord-023095-4dannjjm 2045 8 potentially potentially RB cord-023095-4dannjjm 2045 9 leading lead VBG cord-023095-4dannjjm 2045 10 to to IN cord-023095-4dannjjm 2045 11 misdiagnoses misdiagnose NNS cord-023095-4dannjjm 2045 12 . . . cord-023095-4dannjjm 2046 1 Diabetes diabetes NN cord-023095-4dannjjm 2046 2 mellitus mellitus NN cord-023095-4dannjjm 2046 3 is be VBZ cord-023095-4dannjjm 2046 4 one one CD cord-023095-4dannjjm 2046 5 of of IN cord-023095-4dannjjm 2046 6 the the DT cord-023095-4dannjjm 2046 7 most most RBS cord-023095-4dannjjm 2046 8 common common JJ cord-023095-4dannjjm 2046 9 feline feline JJ cord-023095-4dannjjm 2046 10 endocrinopathies endocrinopathie NNS cord-023095-4dannjjm 2046 11 and and CC cord-023095-4dannjjm 2046 12 is be VBZ cord-023095-4dannjjm 2046 13 considered consider VBN cord-023095-4dannjjm 2046 14 to to TO cord-023095-4dannjjm 2046 15 have have VB cord-023095-4dannjjm 2046 16 a a DT cord-023095-4dannjjm 2046 17 similar similar JJ cord-023095-4dannjjm 2046 18 pathophysiological pathophysiological JJ cord-023095-4dannjjm 2046 19 basis basis NN cord-023095-4dannjjm 2046 20 to to IN cord-023095-4dannjjm 2046 21 human human JJ cord-023095-4dannjjm 2046 22 type type NN cord-023095-4dannjjm 2046 23 2 2 CD cord-023095-4dannjjm 2046 24 diabetes diabete NNS cord-023095-4dannjjm 2046 25 . . . cord-023095-4dannjjm 2047 1 Several several JJ cord-023095-4dannjjm 2047 2 studies study NNS cord-023095-4dannjjm 2047 3 have have VBP cord-023095-4dannjjm 2047 4 identified identify VBN cord-023095-4dannjjm 2047 5 risk risk NN cord-023095-4dannjjm 2047 6 factors factor NNS cord-023095-4dannjjm 2047 7 for for IN cord-023095-4dannjjm 2047 8 development development NN cord-023095-4dannjjm 2047 9 of of IN cord-023095-4dannjjm 2047 10 diabetes diabetes NN cord-023095-4dannjjm 2047 11 mellitus mellitus NN cord-023095-4dannjjm 2047 12 in in IN cord-023095-4dannjjm 2047 13 cats cat NNS cord-023095-4dannjjm 2047 14 , , , cord-023095-4dannjjm 2047 15 which which WDT cord-023095-4dannjjm 2047 16 include include VBP cord-023095-4dannjjm 2047 17 age age NN cord-023095-4dannjjm 2047 18 , , , cord-023095-4dannjjm 2047 19 obesity obesity NN cord-023095-4dannjjm 2047 20 , , , cord-023095-4dannjjm 2047 21 inappropriate inappropriate JJ cord-023095-4dannjjm 2047 22 diet diet NN cord-023095-4dannjjm 2047 23 and and CC cord-023095-4dannjjm 2047 24 physical physical JJ cord-023095-4dannjjm 2047 25 inactivity inactivity NN cord-023095-4dannjjm 2047 26 . . . cord-023095-4dannjjm 2048 1 However however RB cord-023095-4dannjjm 2048 2 , , , cord-023095-4dannjjm 2048 3 to to IN cord-023095-4dannjjm 2048 4 date date NN cord-023095-4dannjjm 2048 5 , , , cord-023095-4dannjjm 2048 6 no no DT cord-023095-4dannjjm 2048 7 specific specific JJ cord-023095-4dannjjm 2048 8 genetic genetic JJ cord-023095-4dannjjm 2048 9 risk risk NN cord-023095-4dannjjm 2048 10 factors factor NNS cord-023095-4dannjjm 2048 11 have have VBP cord-023095-4dannjjm 2048 12 been be VBN cord-023095-4dannjjm 2048 13 identified identify VBN cord-023095-4dannjjm 2048 14 . . . cord-023095-4dannjjm 2049 1 Genome genome NN cord-023095-4dannjjm 2049 2 - - HYPH cord-023095-4dannjjm 2049 3 wide wide JJ cord-023095-4dannjjm 2049 4 association association NN cord-023095-4dannjjm 2049 5 studies study NNS cord-023095-4dannjjm 2049 6 in in IN cord-023095-4dannjjm 2049 7 humans human NNS cord-023095-4dannjjm 2049 8 have have VBP cord-023095-4dannjjm 2049 9 identified identify VBN cord-023095-4dannjjm 2049 10 several several JJ cord-023095-4dannjjm 2049 11 genes gene NNS cord-023095-4dannjjm 2049 12 that that WDT cord-023095-4dannjjm 2049 13 predispose predispose VBP cord-023095-4dannjjm 2049 14 to to IN cord-023095-4dannjjm 2049 15 obesity obesity NN cord-023095-4dannjjm 2049 16 and/or and/or CC cord-023095-4dannjjm 2049 17 diabetes diabetes NN cord-023095-4dannjjm 2049 18 mellitus mellitus NN cord-023095-4dannjjm 2049 19 , , , cord-023095-4dannjjm 2049 20 one one CD cord-023095-4dannjjm 2049 21 of of IN cord-023095-4dannjjm 2049 22 which which WDT cord-023095-4dannjjm 2049 23 is be VBZ cord-023095-4dannjjm 2049 24 the the DT cord-023095-4dannjjm 2049 25 melanocortin melanocortin NNP cord-023095-4dannjjm 2049 26 receptor receptor NN cord-023095-4dannjjm 2049 27 4 4 CD cord-023095-4dannjjm 2049 28 ( ( -LRB- cord-023095-4dannjjm 2049 29 MC4R MC4R NNP cord-023095-4dannjjm 2049 30 ) ) -RRB- cord-023095-4dannjjm 2049 31 gene gene NN cord-023095-4dannjjm 2049 32 . . . cord-023095-4dannjjm 2050 1 The the DT cord-023095-4dannjjm 2050 2 aim aim NN cord-023095-4dannjjm 2050 3 of of IN cord-023095-4dannjjm 2050 4 the the DT cord-023095-4dannjjm 2050 5 current current JJ cord-023095-4dannjjm 2050 6 study study NN cord-023095-4dannjjm 2050 7 was be VBD cord-023095-4dannjjm 2050 8 to to TO cord-023095-4dannjjm 2050 9 identify identify VB cord-023095-4dannjjm 2050 10 polymorphisms polymorphism NNS cord-023095-4dannjjm 2050 11 ( ( -LRB- cord-023095-4dannjjm 2050 12 SNPs SNPs NNP cord-023095-4dannjjm 2050 13 ) ) -RRB- cord-023095-4dannjjm 2050 14 in in IN cord-023095-4dannjjm 2050 15 the the DT cord-023095-4dannjjm 2050 16 feline feline JJ cord-023095-4dannjjm 2050 17 MC4R MC4R NNP cord-023095-4dannjjm 2050 18 gene gene NN cord-023095-4dannjjm 2050 19 and and CC cord-023095-4dannjjm 2050 20 to to TO cord-023095-4dannjjm 2050 21 use use VB cord-023095-4dannjjm 2050 22 these these DT cord-023095-4dannjjm 2050 23 to to TO cord-023095-4dannjjm 2050 24 perform perform VB cord-023095-4dannjjm 2050 25 a a DT cord-023095-4dannjjm 2050 26 case case NN cord-023095-4dannjjm 2050 27 : : : cord-023095-4dannjjm 2050 28 control control NN cord-023095-4dannjjm 2050 29 study study NN cord-023095-4dannjjm 2050 30 to to TO cord-023095-4dannjjm 2050 31 determine determine VB cord-023095-4dannjjm 2050 32 whether whether IN cord-023095-4dannjjm 2050 33 these these DT cord-023095-4dannjjm 2050 34 candidate candidate NN cord-023095-4dannjjm 2050 35 gene gene NN cord-023095-4dannjjm 2050 36 SNPs SNPs NNPS cord-023095-4dannjjm 2050 37 were be VBD cord-023095-4dannjjm 2050 38 associated associate VBN cord-023095-4dannjjm 2050 39 with with IN cord-023095-4dannjjm 2050 40 diabetes diabetes NN cord-023095-4dannjjm 2050 41 mellitus mellitus NN cord-023095-4dannjjm 2050 42 in in IN cord-023095-4dannjjm 2050 43 cats cat NNS cord-023095-4dannjjm 2050 44 . . . cord-023095-4dannjjm 2051 1 Genomic genomic JJ cord-023095-4dannjjm 2051 2 DNA dna NN cord-023095-4dannjjm 2051 3 from from IN cord-023095-4dannjjm 2051 4 10 10 CD cord-023095-4dannjjm 2051 5 cats cat NNS cord-023095-4dannjjm 2051 6 ( ( -LRB- cord-023095-4dannjjm 2051 7 6 6 CD cord-023095-4dannjjm 2051 8 domestic domestic JJ cord-023095-4dannjjm 2051 9 short short JJ cord-023095-4dannjjm 2051 10 hair hair NN cord-023095-4dannjjm 2051 11 [ [ -LRB- cord-023095-4dannjjm 2051 12 DSH DSH NNP cord-023095-4dannjjm 2051 13 ] ] -RRB- cord-023095-4dannjjm 2051 14 , , , cord-023095-4dannjjm 2051 15 4 4 CD cord-023095-4dannjjm 2051 16 Burmese Burmese NNP cord-023095-4dannjjm 2051 17 ) ) -RRB- cord-023095-4dannjjm 2051 18 was be VBD cord-023095-4dannjjm 2051 19 initially initially RB cord-023095-4dannjjm 2051 20 analysed analyse VBN cord-023095-4dannjjm 2051 21 by by IN cord-023095-4dannjjm 2051 22 PCR PCR NNP cord-023095-4dannjjm 2051 23 and and CC cord-023095-4dannjjm 2051 24 direct direct JJ cord-023095-4dannjjm 2051 25 sequencing sequencing NN cord-023095-4dannjjm 2051 26 using use VBG cord-023095-4dannjjm 2051 27 felMC4R felmc4r NN cord-023095-4dannjjm 2051 28 - - HYPH cord-023095-4dannjjm 2051 29 specific specific JJ cord-023095-4dannjjm 2051 30 primers primer NNS cord-023095-4dannjjm 2051 31 , , , cord-023095-4dannjjm 2051 32 which which WDT cord-023095-4dannjjm 2051 33 identified identify VBD cord-023095-4dannjjm 2051 34 a a DT cord-023095-4dannjjm 2051 35 missense missense NN cord-023095-4dannjjm 2051 36 mutation mutation NN cord-023095-4dannjjm 2051 37 ( ( -LRB- cord-023095-4dannjjm 2051 38 MC4R mc4r NN cord-023095-4dannjjm 2051 39 : : : cord-023095-4dannjjm 2051 40 c.92 c.92 NNP cord-023095-4dannjjm 2051 41 C C NNP cord-023095-4dannjjm 2051 42 4 4 CD cord-023095-4dannjjm 2051 43 T T NNP cord-023095-4dannjjm 2051 44 ) ) -RRB- cord-023095-4dannjjm 2051 45 in in IN cord-023095-4dannjjm 2051 46 the the DT cord-023095-4dannjjm 2051 47 region region NN cord-023095-4dannjjm 2051 48 encoding encode VBG cord-023095-4dannjjm 2051 49 the the DT cord-023095-4dannjjm 2051 50 extracellular extracellular JJ cord-023095-4dannjjm 2051 51 domain domain NN cord-023095-4dannjjm 2051 52 of of IN cord-023095-4dannjjm 2051 53 the the DT cord-023095-4dannjjm 2051 54 receptor receptor NN cord-023095-4dannjjm 2051 55 protein protein NN cord-023095-4dannjjm 2051 56 in in IN cord-023095-4dannjjm 2051 57 DSH DSH NNP cord-023095-4dannjjm 2051 58 cats cat NNS cord-023095-4dannjjm 2051 59 only only RB cord-023095-4dannjjm 2051 60 . . . cord-023095-4dannjjm 2052 1 One one CD cord-023095-4dannjjm 2052 2 hundred hundred CD cord-023095-4dannjjm 2052 3 and and CC cord-023095-4dannjjm 2052 4 nineteen nineteen CD cord-023095-4dannjjm 2052 5 DSH DSH NNP cord-023095-4dannjjm 2052 6 cats cat NNS cord-023095-4dannjjm 2052 7 were be VBD cord-023095-4dannjjm 2052 8 subsequently subsequently RB cord-023095-4dannjjm 2052 9 recruited recruit VBN cord-023095-4dannjjm 2052 10 into into IN cord-023095-4dannjjm 2052 11 the the DT cord-023095-4dannjjm 2052 12 case case NN cord-023095-4dannjjm 2052 13 : : : cord-023095-4dannjjm 2052 14 control control NN cord-023095-4dannjjm 2052 15 study study NN cord-023095-4dannjjm 2052 16 . . . cord-023095-4dannjjm 2053 1 Fifty fifty CD cord-023095-4dannjjm 2053 2 nine nine CD cord-023095-4dannjjm 2053 3 cats cat NNS cord-023095-4dannjjm 2053 4 were be VBD cord-023095-4dannjjm 2053 5 obese obese JJ cord-023095-4dannjjm 2053 6 diabetic diabetic JJ cord-023095-4dannjjm 2053 7 ( ( -LRB- cord-023095-4dannjjm 2053 8 29 29 CD cord-023095-4dannjjm 2053 9 male male NN cord-023095-4dannjjm 2053 10 , , , cord-023095-4dannjjm 2053 11 30 30 CD cord-023095-4dannjjm 2053 12 female female JJ cord-023095-4dannjjm 2053 13 ) ) -RRB- cord-023095-4dannjjm 2053 14 , , , cord-023095-4dannjjm 2053 15 mean mean VB cord-023095-4dannjjm 2053 16 age age NN cord-023095-4dannjjm 2053 17 11.8 11.8 CD cord-023095-4dannjjm 2053 18 years year NNS cord-023095-4dannjjm 2054 1 ( ( -LRB- cord-023095-4dannjjm 2054 2 range range NNP cord-023095-4dannjjm 2054 3 6 6 CD cord-023095-4dannjjm 2054 4 - - HYPH cord-023095-4dannjjm 2054 5 18y 18y CD cord-023095-4dannjjm 2054 6 ) ) -RRB- cord-023095-4dannjjm 2054 7 ; ; : cord-023095-4dannjjm 2054 8 mean mean VB cord-023095-4dannjjm 2054 9 weight weight NN cord-023095-4dannjjm 2054 10 6.68 6.68 CD cord-023095-4dannjjm 2054 11 kg kg NNS cord-023095-4dannjjm 2054 12 ( ( -LRB- cord-023095-4dannjjm 2054 13 range range NNP cord-023095-4dannjjm 2054 14 5.15 5.15 CD cord-023095-4dannjjm 2054 15 - - SYM cord-023095-4dannjjm 2054 16 10 10 CD cord-023095-4dannjjm 2054 17 kg kg NNP cord-023095-4dannjjm 2054 18 ) ) -RRB- cord-023095-4dannjjm 2054 19 . . . cord-023095-4dannjjm 2055 1 Sixty sixty CD cord-023095-4dannjjm 2055 2 lean lean JJ cord-023095-4dannjjm 2055 3 cats cat NNS cord-023095-4dannjjm 2055 4 were be VBD cord-023095-4dannjjm 2055 5 used use VBN cord-023095-4dannjjm 2055 6 as as IN cord-023095-4dannjjm 2055 7 controls control NNS cord-023095-4dannjjm 2055 8 ( ( -LRB- cord-023095-4dannjjm 2055 9 30 30 CD cord-023095-4dannjjm 2055 10 male male NN cord-023095-4dannjjm 2055 11 , , , cord-023095-4dannjjm 2055 12 30 30 CD cord-023095-4dannjjm 2055 13 female female JJ cord-023095-4dannjjm 2055 14 ) ) -RRB- cord-023095-4dannjjm 2055 15 , , , cord-023095-4dannjjm 2055 16 mean mean VB cord-023095-4dannjjm 2055 17 age age NN cord-023095-4dannjjm 2055 18 13.81 13.81 CD cord-023095-4dannjjm 2055 19 years year NNS cord-023095-4dannjjm 2056 1 ( ( -LRB- cord-023095-4dannjjm 2056 2 range range NNP cord-023095-4dannjjm 2056 3 9 9 CD cord-023095-4dannjjm 2056 4 - - SYM cord-023095-4dannjjm 2056 5 19y 19y CD cord-023095-4dannjjm 2056 6 ) ) -RRB- cord-023095-4dannjjm 2056 7 , , , cord-023095-4dannjjm 2056 8 mean mean VBP cord-023095-4dannjjm 2056 9 weight weight NN cord-023095-4dannjjm 2056 10 3.99 3.99 CD cord-023095-4dannjjm 2056 11 kg kg NNP cord-023095-4dannjjm 2056 12 ( ( -LRB- cord-023095-4dannjjm 2056 13 range range NNP cord-023095-4dannjjm 2056 14 2.56 2.56 CD cord-023095-4dannjjm 2056 15 - - SYM cord-023095-4dannjjm 2056 16 5.68 5.68 CD cord-023095-4dannjjm 2056 17 kg kg NNS cord-023095-4dannjjm 2056 18 ) ) -RRB- cord-023095-4dannjjm 2056 19 . . . cord-023095-4dannjjm 2057 1 The the DT cord-023095-4dannjjm 2057 2 T t NN cord-023095-4dannjjm 2057 3 to to IN cord-023095-4dannjjm 2057 4 C c NN cord-023095-4dannjjm 2057 5 base base NN cord-023095-4dannjjm 2057 6 change change NN cord-023095-4dannjjm 2057 7 alters alter VBZ cord-023095-4dannjjm 2057 8 a a DT cord-023095-4dannjjm 2057 9 restriction restriction NN cord-023095-4dannjjm 2057 10 site site NN cord-023095-4dannjjm 2057 11 in in IN cord-023095-4dannjjm 2057 12 the the DT cord-023095-4dannjjm 2057 13 sequence sequence NN cord-023095-4dannjjm 2057 14 recognized recognize VBN cord-023095-4dannjjm 2057 15 by by IN cord-023095-4dannjjm 2057 16 the the DT cord-023095-4dannjjm 2057 17 enzyme enzyme NN cord-023095-4dannjjm 2057 18 BstOI BstOI NNS cord-023095-4dannjjm 2057 19 , , , cord-023095-4dannjjm 2057 20 such such JJ cord-023095-4dannjjm 2057 21 that that IN cord-023095-4dannjjm 2057 22 DNA dna NN cord-023095-4dannjjm 2057 23 from from IN cord-023095-4dannjjm 2057 24 cats cat NNS cord-023095-4dannjjm 2057 25 with with IN cord-023095-4dannjjm 2057 26 the the DT cord-023095-4dannjjm 2057 27 mutant mutant NN cord-023095-4dannjjm 2057 28 ( ( -LRB- cord-023095-4dannjjm 2057 29 C C NNP cord-023095-4dannjjm 2057 30 ) ) -RRB- cord-023095-4dannjjm 2057 31 allele allele NN cord-023095-4dannjjm 2057 32 can can MD cord-023095-4dannjjm 2057 33 be be VB cord-023095-4dannjjm 2057 34 cut cut VBN cord-023095-4dannjjm 2057 35 , , , cord-023095-4dannjjm 2057 36 whereas whereas IN cord-023095-4dannjjm 2057 37 that that DT cord-023095-4dannjjm 2057 38 from from IN cord-023095-4dannjjm 2057 39 the the DT cord-023095-4dannjjm 2057 40 wild wild JJ cord-023095-4dannjjm 2057 41 - - HYPH cord-023095-4dannjjm 2057 42 type type NN cord-023095-4dannjjm 2057 43 ( ( -LRB- cord-023095-4dannjjm 2057 44 T T NNP cord-023095-4dannjjm 2057 45 ) ) -RRB- cord-023095-4dannjjm 2057 46 allele allele NN cord-023095-4dannjjm 2057 47 can can MD cord-023095-4dannjjm 2057 48 not not RB cord-023095-4dannjjm 2057 49 . . . cord-023095-4dannjjm 2058 1 Primers primer NNS cord-023095-4dannjjm 2058 2 were be VBD cord-023095-4dannjjm 2058 3 designed design VBN cord-023095-4dannjjm 2058 4 that that IN cord-023095-4dannjjm 2058 5 flanked flank VBD cord-023095-4dannjjm 2058 6 the the DT cord-023095-4dannjjm 2058 7 mutation mutation NN cord-023095-4dannjjm 2058 8 to to TO cord-023095-4dannjjm 2058 9 allow allow VB cord-023095-4dannjjm 2058 10 PCR PCR NNP cord-023095-4dannjjm 2058 11 amplification amplification NN cord-023095-4dannjjm 2058 12 of of IN cord-023095-4dannjjm 2058 13 this this DT cord-023095-4dannjjm 2058 14 region region NN cord-023095-4dannjjm 2058 15 of of IN cord-023095-4dannjjm 2058 16 MC4R MC4R NNP cord-023095-4dannjjm 2058 17 from from IN cord-023095-4dannjjm 2058 18 genomic genomic JJ cord-023095-4dannjjm 2058 19 DNA dna NN cord-023095-4dannjjm 2058 20 obtained obtain VBN cord-023095-4dannjjm 2058 21 from from IN cord-023095-4dannjjm 2058 22 EDTA EDTA NNP cord-023095-4dannjjm 2058 23 blood blood NN cord-023095-4dannjjm 2058 24 . . . cord-023095-4dannjjm 2059 1 The the DT cord-023095-4dannjjm 2059 2 PCR PCR NNP cord-023095-4dannjjm 2059 3 products product NNS cord-023095-4dannjjm 2059 4 were be VBD cord-023095-4dannjjm 2059 5 purified purify VBN cord-023095-4dannjjm 2059 6 and and CC cord-023095-4dannjjm 2059 7 subject subject JJ cord-023095-4dannjjm 2059 8 to to IN cord-023095-4dannjjm 2059 9 restriction restriction NN cord-023095-4dannjjm 2059 10 fragment fragment NN cord-023095-4dannjjm 2059 11 length length NN cord-023095-4dannjjm 2059 12 polymorphism polymorphism NN cord-023095-4dannjjm 2059 13 ( ( -LRB- cord-023095-4dannjjm 2059 14 RFLP RFLP NNP cord-023095-4dannjjm 2059 15 ) ) -RRB- cord-023095-4dannjjm 2059 16 analysis analysis NN cord-023095-4dannjjm 2059 17 . . . cord-023095-4dannjjm 2060 1 BstOI BstOI VBN cord-023095-4dannjjm 2060 2 digestion digestion NN cord-023095-4dannjjm 2060 3 products product NNS cord-023095-4dannjjm 2060 4 were be VBD cord-023095-4dannjjm 2060 5 then then RB cord-023095-4dannjjm 2060 6 analysed analyse VBN cord-023095-4dannjjm 2060 7 by by IN cord-023095-4dannjjm 2060 8 agarose agarose JJ cord-023095-4dannjjm 2060 9 gel gel NN cord-023095-4dannjjm 2060 10 electrophoresis electrophoresis NN cord-023095-4dannjjm 2060 11 . . . cord-023095-4dannjjm 2061 1 Of of IN cord-023095-4dannjjm 2061 2 the the DT cord-023095-4dannjjm 2061 3 59 59 CD cord-023095-4dannjjm 2061 4 diabetic diabetic JJ cord-023095-4dannjjm 2061 5 cats cat NNS cord-023095-4dannjjm 2061 6 , , , cord-023095-4dannjjm 2061 7 32 32 CD cord-023095-4dannjjm 2061 8 ( ( -LRB- cord-023095-4dannjjm 2061 9 54 54 CD cord-023095-4dannjjm 2061 10 % % NN cord-023095-4dannjjm 2061 11 ) ) -RRB- cord-023095-4dannjjm 2061 12 were be VBD cord-023095-4dannjjm 2061 13 homozygous homozygous JJ cord-023095-4dannjjm 2061 14 for for IN cord-023095-4dannjjm 2061 15 the the DT cord-023095-4dannjjm 2061 16 mutation mutation NN cord-023095-4dannjjm 2061 17 ( ( -LRB- cord-023095-4dannjjm 2061 18 CC CC NNP cord-023095-4dannjjm 2061 19 ) ) -RRB- cord-023095-4dannjjm 2061 20 , , , cord-023095-4dannjjm 2061 21 compared compare VBN cord-023095-4dannjjm 2061 22 to to IN cord-023095-4dannjjm 2061 23 21 21 CD cord-023095-4dannjjm 2061 24 ( ( -LRB- cord-023095-4dannjjm 2061 25 35 35 CD cord-023095-4dannjjm 2061 26 % % NN cord-023095-4dannjjm 2061 27 ) ) -RRB- cord-023095-4dannjjm 2061 28 of of IN cord-023095-4dannjjm 2061 29 60 60 CD cord-023095-4dannjjm 2061 30 control control NN cord-023095-4dannjjm 2061 31 cats cat NNS cord-023095-4dannjjm 2061 32 . . . cord-023095-4dannjjm 2062 1 Statistical statistical JJ cord-023095-4dannjjm 2062 2 analysis analysis NN cord-023095-4dannjjm 2062 3 ( ( -LRB- cord-023095-4dannjjm 2062 4 two two CD cord-023095-4dannjjm 2062 5 tailed tailed JJ cord-023095-4dannjjm 2062 6 Fisher Fisher NNP cord-023095-4dannjjm 2062 7 's 's POS cord-023095-4dannjjm 2062 8 square square JJ cord-023095-4dannjjm 2062 9 test test NN cord-023095-4dannjjm 2062 10 ) ) -RRB- cord-023095-4dannjjm 2062 11 revealed reveal VBD cord-023095-4dannjjm 2062 12 that that IN cord-023095-4dannjjm 2062 13 this this DT cord-023095-4dannjjm 2062 14 difference difference NN cord-023095-4dannjjm 2062 15 between between IN cord-023095-4dannjjm 2062 16 groups group NNS cord-023095-4dannjjm 2062 17 was be VBD cord-023095-4dannjjm 2062 18 statistically statistically RB cord-023095-4dannjjm 2062 19 significant significant JJ cord-023095-4dannjjm 2062 20 ( ( -LRB- cord-023095-4dannjjm 2062 21 p p NN cord-023095-4dannjjm 2062 22 5 5 CD cord-023095-4dannjjm 2062 23 0.0431 0.0431 CD cord-023095-4dannjjm 2062 24 ) ) -RRB- cord-023095-4dannjjm 2062 25 . . . cord-023095-4dannjjm 2063 1 In in IN cord-023095-4dannjjm 2063 2 conclusion conclusion NN cord-023095-4dannjjm 2063 3 , , , cord-023095-4dannjjm 2063 4 this this DT cord-023095-4dannjjm 2063 5 pilot pilot NN cord-023095-4dannjjm 2063 6 study study NN cord-023095-4dannjjm 2063 7 has have VBZ cord-023095-4dannjjm 2063 8 identified identify VBN cord-023095-4dannjjm 2063 9 a a DT cord-023095-4dannjjm 2063 10 missense missense JJ cord-023095-4dannjjm 2063 11 mutation mutation NN cord-023095-4dannjjm 2063 12 in in IN cord-023095-4dannjjm 2063 13 the the DT cord-023095-4dannjjm 2063 14 coding code VBG cord-023095-4dannjjm 2063 15 sequence sequence NN cord-023095-4dannjjm 2063 16 of of IN cord-023095-4dannjjm 2063 17 MC4R. MC4R. NNP cord-023095-4dannjjm 2064 1 This this DT cord-023095-4dannjjm 2064 2 could could MD cord-023095-4dannjjm 2064 3 be be VB cord-023095-4dannjjm 2064 4 an an DT cord-023095-4dannjjm 2064 5 important important JJ cord-023095-4dannjjm 2064 6 predisposing predisposing NN cord-023095-4dannjjm 2064 7 factor factor NN cord-023095-4dannjjm 2064 8 for for IN cord-023095-4dannjjm 2064 9 development development NN cord-023095-4dannjjm 2064 10 of of IN cord-023095-4dannjjm 2064 11 diabetes diabetes NN cord-023095-4dannjjm 2064 12 and/or and/or CC cord-023095-4dannjjm 2064 13 obesity obesity NN cord-023095-4dannjjm 2064 14 in in IN cord-023095-4dannjjm 2064 15 DSH DSH NNP cord-023095-4dannjjm 2064 16 cats cat NNS cord-023095-4dannjjm 2064 17 . . . cord-023095-4dannjjm 2065 1 Polymorphisms polymorphism NNS cord-023095-4dannjjm 2065 2 in in IN cord-023095-4dannjjm 2065 3 a a DT cord-023095-4dannjjm 2065 4 similar similar JJ cord-023095-4dannjjm 2065 5 region region NN cord-023095-4dannjjm 2065 6 of of IN cord-023095-4dannjjm 2065 7 human human JJ cord-023095-4dannjjm 2065 8 MC4R MC4R NNP cord-023095-4dannjjm 2065 9 predispose predispose VB cord-023095-4dannjjm 2065 10 to to IN cord-023095-4dannjjm 2065 11 obesity obesity NN cord-023095-4dannjjm 2065 12 , , , cord-023095-4dannjjm 2065 13 which which WDT cord-023095-4dannjjm 2065 14 in in IN cord-023095-4dannjjm 2065 15 turn turn NN cord-023095-4dannjjm 2065 16 is be VBZ cord-023095-4dannjjm 2065 17 a a DT cord-023095-4dannjjm 2065 18 major major JJ cord-023095-4dannjjm 2065 19 risk risk NN cord-023095-4dannjjm 2065 20 factor factor NN cord-023095-4dannjjm 2065 21 for for IN cord-023095-4dannjjm 2065 22 Type type NN cord-023095-4dannjjm 2065 23 2 2 CD cord-023095-4dannjjm 2065 24 diabetes diabete NNS cord-023095-4dannjjm 2065 25 . . . cord-023095-4dannjjm 2066 1 Hyperadrenocorticism Hyperadrenocorticism NNP cord-023095-4dannjjm 2066 2 ( ( -LRB- cord-023095-4dannjjm 2066 3 HAC HAC NNP cord-023095-4dannjjm 2066 4 ) ) -RRB- cord-023095-4dannjjm 2066 5 is be VBZ cord-023095-4dannjjm 2066 6 one one CD cord-023095-4dannjjm 2066 7 of of IN cord-023095-4dannjjm 2066 8 the the DT cord-023095-4dannjjm 2066 9 most most RBS cord-023095-4dannjjm 2066 10 common common JJ cord-023095-4dannjjm 2066 11 endocrine endocrine JJ cord-023095-4dannjjm 2066 12 disorders disorder NNS cord-023095-4dannjjm 2066 13 of of IN cord-023095-4dannjjm 2066 14 dogs dog NNS cord-023095-4dannjjm 2066 15 . . . cord-023095-4dannjjm 2067 1 The the DT cord-023095-4dannjjm 2067 2 two two CD cord-023095-4dannjjm 2067 3 most most RBS cord-023095-4dannjjm 2067 4 effective effective JJ cord-023095-4dannjjm 2067 5 medical medical JJ cord-023095-4dannjjm 2067 6 treatments treatment NNS cord-023095-4dannjjm 2067 7 are be VBP cord-023095-4dannjjm 2067 8 trilostane trilostane NNP cord-023095-4dannjjm 2067 9 ( ( -LRB- cord-023095-4dannjjm 2067 10 Vetoryl Vetoryl NNP cord-023095-4dannjjm 2067 11 s s POS cord-023095-4dannjjm 2067 12 ) ) -RRB- cord-023095-4dannjjm 2067 13 and and CC cord-023095-4dannjjm 2067 14 mitotane mitotane NNP cord-023095-4dannjjm 2067 15 ( ( -LRB- cord-023095-4dannjjm 2067 16 Lysodren Lysodren NNP cord-023095-4dannjjm 2067 17 s s POS cord-023095-4dannjjm 2067 18 ) ) -RRB- cord-023095-4dannjjm 2067 19 . . . cord-023095-4dannjjm 2068 1 Previous previous JJ cord-023095-4dannjjm 2068 2 studies study NNS cord-023095-4dannjjm 2068 3 evaluating evaluate VBG cord-023095-4dannjjm 2068 4 the the DT cord-023095-4dannjjm 2068 5 effect effect NN cord-023095-4dannjjm 2068 6 of of IN cord-023095-4dannjjm 2068 7 treatment treatment NN cord-023095-4dannjjm 2068 8 on on IN cord-023095-4dannjjm 2068 9 aldosterone aldosterone NN cord-023095-4dannjjm 2068 10 secretion secretion NN cord-023095-4dannjjm 2068 11 measured measure VBD cord-023095-4dannjjm 2068 12 the the DT cord-023095-4dannjjm 2068 13 hormone hormone NN cord-023095-4dannjjm 2068 14 at at IN cord-023095-4dannjjm 2068 15 60 60 CD cord-023095-4dannjjm 2068 16 min min NN cord-023095-4dannjjm 2068 17 post post JJ cord-023095-4dannjjm 2068 18 - - JJ cord-023095-4dannjjm 2068 19 ACTH ACTH NNP cord-023095-4dannjjm 2068 20 administration administration NN cord-023095-4dannjjm 2068 21 . . . cord-023095-4dannjjm 2069 1 However however RB cord-023095-4dannjjm 2069 2 , , , cord-023095-4dannjjm 2069 3 the the DT cord-023095-4dannjjm 2069 4 optimal optimal JJ cord-023095-4dannjjm 2069 5 sampling sampling NN cord-023095-4dannjjm 2069 6 time time NN cord-023095-4dannjjm 2069 7 would would MD cord-023095-4dannjjm 2069 8 be be VB cord-023095-4dannjjm 2069 9 at at IN cord-023095-4dannjjm 2069 10 the the DT cord-023095-4dannjjm 2069 11 time time NN cord-023095-4dannjjm 2069 12 of of IN cord-023095-4dannjjm 2069 13 maximal maximal JJ cord-023095-4dannjjm 2069 14 secretion secretion NN cord-023095-4dannjjm 2069 15 , , , cord-023095-4dannjjm 2069 16 which which WDT cord-023095-4dannjjm 2069 17 occurs occur VBZ cord-023095-4dannjjm 2069 18 30 30 CD cord-023095-4dannjjm 2069 19 minutes minute NNS cord-023095-4dannjjm 2069 20 after after IN cord-023095-4dannjjm 2069 21 the the DT cord-023095-4dannjjm 2069 22 5 5 CD cord-023095-4dannjjm 2069 23 mg mg NNP cord-023095-4dannjjm 2069 24 / / SYM cord-023095-4dannjjm 2069 25 kg kg NN cord-023095-4dannjjm 2069 26 dose dose NN cord-023095-4dannjjm 2069 27 commonly commonly RB cord-023095-4dannjjm 2069 28 used use VBN cord-023095-4dannjjm 2069 29 for for IN cord-023095-4dannjjm 2069 30 the the DT cord-023095-4dannjjm 2069 31 test test NN cord-023095-4dannjjm 2069 32 ( ( -LRB- cord-023095-4dannjjm 2069 33 Carlson Carlson NNP cord-023095-4dannjjm 2069 34 et et NNP cord-023095-4dannjjm 2069 35 al al NNP cord-023095-4dannjjm 2069 36 , , , cord-023095-4dannjjm 2069 37 JVIM JVIM NNP cord-023095-4dannjjm 2069 38 , , , cord-023095-4dannjjm 2069 39 2010 2010 CD cord-023095-4dannjjm 2069 40 ) ) -RRB- cord-023095-4dannjjm 2069 41 . . . cord-023095-4dannjjm 2070 1 Thus thus RB cord-023095-4dannjjm 2070 2 , , , cord-023095-4dannjjm 2070 3 the the DT cord-023095-4dannjjm 2070 4 true true JJ cord-023095-4dannjjm 2070 5 effect effect NN cord-023095-4dannjjm 2070 6 of of IN cord-023095-4dannjjm 2070 7 either either DT cord-023095-4dannjjm 2070 8 medication medication NN cord-023095-4dannjjm 2070 9 on on IN cord-023095-4dannjjm 2070 10 aldosterone aldosterone NN cord-023095-4dannjjm 2070 11 secretory secretory JJ cord-023095-4dannjjm 2070 12 capacity capacity NN cord-023095-4dannjjm 2070 13 is be VBZ cord-023095-4dannjjm 2070 14 unknown unknown JJ cord-023095-4dannjjm 2070 15 . . . cord-023095-4dannjjm 2071 1 Our -PRON- PRP$ cord-023095-4dannjjm 2071 2 objectives objective NNS cord-023095-4dannjjm 2071 3 were be VBD cord-023095-4dannjjm 2071 4 : : : cord-023095-4dannjjm 2071 5 1 1 LS cord-023095-4dannjjm 2071 6 ) ) -RRB- cord-023095-4dannjjm 2071 7 to to TO cord-023095-4dannjjm 2071 8 assess assess VB cord-023095-4dannjjm 2071 9 and and CC cord-023095-4dannjjm 2071 10 compare compare VB cord-023095-4dannjjm 2071 11 the the DT cord-023095-4dannjjm 2071 12 effect effect NN cord-023095-4dannjjm 2071 13 of of IN cord-023095-4dannjjm 2071 14 treatment treatment NN cord-023095-4dannjjm 2071 15 with with IN cord-023095-4dannjjm 2071 16 trilostane trilostane NNP cord-023095-4dannjjm 2071 17 and and CC cord-023095-4dannjjm 2071 18 mitotane mitotane NNP cord-023095-4dannjjm 2071 19 in in IN cord-023095-4dannjjm 2071 20 dogs dog NNS cord-023095-4dannjjm 2071 21 with with IN cord-023095-4dannjjm 2071 22 pituitarydependent pituitarydependent NN cord-023095-4dannjjm 2071 23 HAC HAC NNP cord-023095-4dannjjm 2071 24 ( ( -LRB- cord-023095-4dannjjm 2071 25 PDH PDH NNP cord-023095-4dannjjm 2071 26 ) ) -RRB- cord-023095-4dannjjm 2071 27 on on IN cord-023095-4dannjjm 2071 28 aldosterone aldosterone NN cord-023095-4dannjjm 2071 29 secretory secretory JJ cord-023095-4dannjjm 2071 30 reserve reserve NN cord-023095-4dannjjm 2071 31 at at IN cord-023095-4dannjjm 2071 32 30 30 CD cord-023095-4dannjjm 2071 33 min min NN cord-023095-4dannjjm 2071 34 post post JJ cord-023095-4dannjjm 2071 35 - - JJ cord-023095-4dannjjm 2071 36 ACTH acth JJ cord-023095-4dannjjm 2071 37 stimulation stimulation NN cord-023095-4dannjjm 2071 38 and and CC cord-023095-4dannjjm 2071 39 2 2 CD cord-023095-4dannjjm 2071 40 ) ) -RRB- cord-023095-4dannjjm 2071 41 to to TO cord-023095-4dannjjm 2071 42 determine determine VB cord-023095-4dannjjm 2071 43 if if IN cord-023095-4dannjjm 2071 44 changes change NNS cord-023095-4dannjjm 2071 45 in in IN cord-023095-4dannjjm 2071 46 aldosterone aldosterone NN cord-023095-4dannjjm 2071 47 concentration concentration NN cord-023095-4dannjjm 2071 48 at at IN cord-023095-4dannjjm 2071 49 that that DT cord-023095-4dannjjm 2071 50 time time NN cord-023095-4dannjjm 2071 51 correlate correlate VBP cord-023095-4dannjjm 2071 52 with with IN cord-023095-4dannjjm 2071 53 changes change NNS cord-023095-4dannjjm 2071 54 in in IN cord-023095-4dannjjm 2071 55 serum serum NN cord-023095-4dannjjm 2071 56 sodium sodium NN cord-023095-4dannjjm 2071 57 and and CC cord-023095-4dannjjm 2071 58 potassium potassium NN cord-023095-4dannjjm 2071 59 concentrations concentration NNS cord-023095-4dannjjm 2071 60 . . . cord-023095-4dannjjm 2072 1 Forty forty CD cord-023095-4dannjjm 2072 2 - - HYPH cord-023095-4dannjjm 2072 3 six six CD cord-023095-4dannjjm 2072 4 dogs dog NNS cord-023095-4dannjjm 2072 5 being be VBG cord-023095-4dannjjm 2072 6 treated treat VBN cord-023095-4dannjjm 2072 7 for for IN cord-023095-4dannjjm 2072 8 PDH PDH NNP cord-023095-4dannjjm 2072 9 with with IN cord-023095-4dannjjm 2072 10 either either DT cord-023095-4dannjjm 2072 11 mitotane mitotane NNP cord-023095-4dannjjm 2072 12 ( ( -LRB- cord-023095-4dannjjm 2072 13 n n NNP cord-023095-4dannjjm 2072 14 5 5 CD cord-023095-4dannjjm 2072 15 30 30 CD cord-023095-4dannjjm 2072 16 ) ) -RRB- cord-023095-4dannjjm 2072 17 or or CC cord-023095-4dannjjm 2072 18 trilostane trilostane NNP cord-023095-4dannjjm 2072 19 ( ( -LRB- cord-023095-4dannjjm 2072 20 n n NNP cord-023095-4dannjjm 2072 21 5 5 CD cord-023095-4dannjjm 2072 22 16 16 CD cord-023095-4dannjjm 2072 23 ) ) -RRB- cord-023095-4dannjjm 2072 24 have have VBP cord-023095-4dannjjm 2072 25 been be VBN cord-023095-4dannjjm 2072 26 enrolled enrol VBN cord-023095-4dannjjm 2072 27 . . . cord-023095-4dannjjm 2073 1 The the DT cord-023095-4dannjjm 2073 2 dogs dog NNS cord-023095-4dannjjm 2073 3 could could MD cord-023095-4dannjjm 2073 4 be be VB cord-023095-4dannjjm 2073 5 treated treat VBN cord-023095-4dannjjm 2073 6 for for IN cord-023095-4dannjjm 2073 7 any any DT cord-023095-4dannjjm 2073 8 length length NN cord-023095-4dannjjm 2073 9 of of IN cord-023095-4dannjjm 2073 10 time time NN cord-023095-4dannjjm 2073 11 . . . cord-023095-4dannjjm 2074 1 All all DT cord-023095-4dannjjm 2074 2 had have VBD cord-023095-4dannjjm 2074 3 ACTH ACTH NNP cord-023095-4dannjjm 2074 4 stimulation stimulation NN cord-023095-4dannjjm 2074 5 tests test NNS cord-023095-4dannjjm 2074 6 performed perform VBN cord-023095-4dannjjm 2074 7 ( ( -LRB- cord-023095-4dannjjm 2074 8 5 5 CD cord-023095-4dannjjm 2074 9 mcg mcg NNP cord-023095-4dannjjm 2074 10 / / SYM cord-023095-4dannjjm 2074 11 kg kg NNP cord-023095-4dannjjm 2074 12 cosyntropin cosyntropin NNP cord-023095-4dannjjm 2074 13 IV IV NNP cord-023095-4dannjjm 2074 14 ) ) -RRB- cord-023095-4dannjjm 2074 15 ; ; : cord-023095-4dannjjm 2074 16 blood blood NN cord-023095-4dannjjm 2074 17 samples sample NNS cord-023095-4dannjjm 2074 18 were be VBD cord-023095-4dannjjm 2074 19 drawn draw VBN cord-023095-4dannjjm 2074 20 before before RB cord-023095-4dannjjm 2074 21 and and CC cord-023095-4dannjjm 2074 22 at at IN cord-023095-4dannjjm 2074 23 30 30 CD cord-023095-4dannjjm 2074 24 and and CC cord-023095-4dannjjm 2074 25 60 60 CD cord-023095-4dannjjm 2074 26 min min NN cord-023095-4dannjjm 2074 27 post post NN cord-023095-4dannjjm 2074 28 - - JJ cord-023095-4dannjjm 2074 29 ACTH ACTH NNP cord-023095-4dannjjm 2074 30 for for IN cord-023095-4dannjjm 2074 31 monitoring monitoring NN cord-023095-4dannjjm 2074 32 of of IN cord-023095-4dannjjm 2074 33 cortisol cortisol NN cord-023095-4dannjjm 2074 34 and and CC cord-023095-4dannjjm 2074 35 aldosterone aldosterone NN cord-023095-4dannjjm 2074 36 concentration concentration NN cord-023095-4dannjjm 2074 37 using use VBG cord-023095-4dannjjm 2074 38 previously previously RB cord-023095-4dannjjm 2074 39 validated validate VBN cord-023095-4dannjjm 2074 40 radioimmunoassays radioimmunoassay NNS cord-023095-4dannjjm 2074 41 . . . cord-023095-4dannjjm 2075 1 Ten ten CD cord-023095-4dannjjm 2075 2 historical historical JJ cord-023095-4dannjjm 2075 3 normal normal JJ cord-023095-4dannjjm 2075 4 controls control NNS cord-023095-4dannjjm 2075 5 were be VBD cord-023095-4dannjjm 2075 6 also also RB cord-023095-4dannjjm 2075 7 included include VBN cord-023095-4dannjjm 2075 8 . . . cord-023095-4dannjjm 2076 1 Serum serum NN cord-023095-4dannjjm 2076 2 sodium sodium NN cord-023095-4dannjjm 2076 3 and and CC cord-023095-4dannjjm 2076 4 potassium potassium NN cord-023095-4dannjjm 2076 5 concentrations concentration NNS cord-023095-4dannjjm 2076 6 were be VBD cord-023095-4dannjjm 2076 7 measured measure VBN cord-023095-4dannjjm 2076 8 in in IN cord-023095-4dannjjm 2076 9 the the DT cord-023095-4dannjjm 2076 10 basal basal NN cord-023095-4dannjjm 2076 11 samples sample NNS cord-023095-4dannjjm 2076 12 . . . cord-023095-4dannjjm 2077 1 A a DT cord-023095-4dannjjm 2077 2 Kruskal Kruskal NNP cord-023095-4dannjjm 2077 3 - - HYPH cord-023095-4dannjjm 2077 4 Wallis Wallis NNP cord-023095-4dannjjm 2077 5 Rank Rank NNP cord-023095-4dannjjm 2077 6 Sum Sum NNP cord-023095-4dannjjm 2077 7 test test NN cord-023095-4dannjjm 2077 8 was be VBD cord-023095-4dannjjm 2077 9 used use VBN cord-023095-4dannjjm 2077 10 to to TO cord-023095-4dannjjm 2077 11 compare compare VB cord-023095-4dannjjm 2077 12 values value NNS cord-023095-4dannjjm 2077 13 between between IN cord-023095-4dannjjm 2077 14 normal normal JJ cord-023095-4dannjjm 2077 15 dogs dog NNS cord-023095-4dannjjm 2077 16 and and CC cord-023095-4dannjjm 2077 17 those those DT cord-023095-4dannjjm 2077 18 treated treat VBN cord-023095-4dannjjm 2077 19 with with IN cord-023095-4dannjjm 2077 20 mitotane mitotane NNP cord-023095-4dannjjm 2077 21 or or CC cord-023095-4dannjjm 2077 22 trilostane trilostane NNP cord-023095-4dannjjm 2077 23 . . . cord-023095-4dannjjm 2078 1 Linear linear JJ cord-023095-4dannjjm 2078 2 regression regression NN cord-023095-4dannjjm 2078 3 analysis analysis NN cord-023095-4dannjjm 2078 4 was be VBD cord-023095-4dannjjm 2078 5 used use VBN cord-023095-4dannjjm 2078 6 to to TO cord-023095-4dannjjm 2078 7 determine determine VB cord-023095-4dannjjm 2078 8 if if IN cord-023095-4dannjjm 2078 9 a a DT cord-023095-4dannjjm 2078 10 correlation correlation NN cord-023095-4dannjjm 2078 11 existed exist VBD cord-023095-4dannjjm 2078 12 between between IN cord-023095-4dannjjm 2078 13 electrolyte electrolyte NN cord-023095-4dannjjm 2078 14 and and CC cord-023095-4dannjjm 2078 15 aldosterone aldosterone NN cord-023095-4dannjjm 2078 16 concentrations concentration NNS cord-023095-4dannjjm 2078 17 or or CC cord-023095-4dannjjm 2078 18 between between IN cord-023095-4dannjjm 2078 19 cortisol cortisol NN cord-023095-4dannjjm 2078 20 and and CC cord-023095-4dannjjm 2078 21 aldosterone aldosterone NN cord-023095-4dannjjm 2078 22 concentrations concentration NNS cord-023095-4dannjjm 2078 23 . . . cord-023095-4dannjjm 2079 1 Significance significance NN cord-023095-4dannjjm 2079 2 was be VBD cord-023095-4dannjjm 2079 3 set set VBN cord-023095-4dannjjm 2079 4 at at IN cord-023095-4dannjjm 2079 5 the the DT cord-023095-4dannjjm 2079 6 p p NN cord-023095-4dannjjm 2079 7 o o NN cord-023095-4dannjjm 2079 8 0.05 0.05 CD cord-023095-4dannjjm 2079 9 level level NN cord-023095-4dannjjm 2079 10 . . . cord-023095-4dannjjm 2080 1 ACTH ACTH NNP cord-023095-4dannjjm 2080 2 - - HYPH cord-023095-4dannjjm 2080 3 stimulated stimulate VBN cord-023095-4dannjjm 2080 4 aldosterone aldosterone NN cord-023095-4dannjjm 2080 5 concentrations concentration NNS cord-023095-4dannjjm 2080 6 in in IN cord-023095-4dannjjm 2081 1 mitotane mitotane NNP cord-023095-4dannjjm 2081 2 - - HYPH cord-023095-4dannjjm 2081 3 treated treat VBN cord-023095-4dannjjm 2081 4 but but CC cord-023095-4dannjjm 2081 5 not not RB cord-023095-4dannjjm 2081 6 trilostane trilostane NN cord-023095-4dannjjm 2081 7 - - HYPH cord-023095-4dannjjm 2081 8 treated treat VBN cord-023095-4dannjjm 2081 9 dogs dog NNS cord-023095-4dannjjm 2081 10 were be VBD cord-023095-4dannjjm 2081 11 significantly significantly RB cord-023095-4dannjjm 2081 12 lower low JJR cord-023095-4dannjjm 2081 13 than than IN cord-023095-4dannjjm 2081 14 that that DT cord-023095-4dannjjm 2081 15 in in IN cord-023095-4dannjjm 2081 16 normal normal JJ cord-023095-4dannjjm 2081 17 dogs dog NNS cord-023095-4dannjjm 2081 18 at at IN cord-023095-4dannjjm 2081 19 both both CC cord-023095-4dannjjm 2081 20 the the DT cord-023095-4dannjjm 2081 21 30 30 CD cord-023095-4dannjjm 2081 22 and and CC cord-023095-4dannjjm 2081 23 60 60 CD cord-023095-4dannjjm 2081 24 min min NN cord-023095-4dannjjm 2081 25 time time NN cord-023095-4dannjjm 2081 26 points point NNS cord-023095-4dannjjm 2081 27 . . . cord-023095-4dannjjm 2082 1 No no DT cord-023095-4dannjjm 2082 2 difference difference NN cord-023095-4dannjjm 2082 3 was be VBD cord-023095-4dannjjm 2082 4 detected detect VBN cord-023095-4dannjjm 2082 5 between between IN cord-023095-4dannjjm 2082 6 aldosterone aldosterone NN cord-023095-4dannjjm 2082 7 concentrations concentration NNS cord-023095-4dannjjm 2082 8 at at IN cord-023095-4dannjjm 2082 9 30 30 CD cord-023095-4dannjjm 2082 10 and and CC cord-023095-4dannjjm 2082 11 60 60 CD cord-023095-4dannjjm 2082 12 min min NN cord-023095-4dannjjm 2082 13 after after IN cord-023095-4dannjjm 2082 14 ACTH ACTH NNP cord-023095-4dannjjm 2082 15 injection injection NN cord-023095-4dannjjm 2082 16 in in IN cord-023095-4dannjjm 2082 17 either either DT cord-023095-4dannjjm 2082 18 treatment treatment NN cord-023095-4dannjjm 2082 19 group group NN cord-023095-4dannjjm 2082 20 . . . cord-023095-4dannjjm 2083 1 A a DT cord-023095-4dannjjm 2083 2 positive positive JJ cord-023095-4dannjjm 2083 3 correlation correlation NN cord-023095-4dannjjm 2083 4 existed exist VBD cord-023095-4dannjjm 2083 5 between between IN cord-023095-4dannjjm 2083 6 the the DT cord-023095-4dannjjm 2083 7 60-min 60-min CD cord-023095-4dannjjm 2083 8 cortisol cortisol NN cord-023095-4dannjjm 2083 9 and and CC cord-023095-4dannjjm 2083 10 30-min 30-min CD cord-023095-4dannjjm 2083 11 aldosterone aldosterone NN cord-023095-4dannjjm 2083 12 concentrations concentration NNS cord-023095-4dannjjm 2083 13 in in IN cord-023095-4dannjjm 2083 14 the the DT cord-023095-4dannjjm 2083 15 trilostane trilostane NNP cord-023095-4dannjjm 2083 16 - - HYPH cord-023095-4dannjjm 2083 17 treated treat VBN cord-023095-4dannjjm 2083 18 group group NN cord-023095-4dannjjm 2083 19 ( ( -LRB- cord-023095-4dannjjm 2083 20 R r NN cord-023095-4dannjjm 2083 21 5 5 CD cord-023095-4dannjjm 2083 22 0.813 0.813 CD cord-023095-4dannjjm 2083 23 ) ) -RRB- cord-023095-4dannjjm 2083 24 , , , cord-023095-4dannjjm 2083 25 i.e. i.e. FW cord-023095-4dannjjm 2083 26 the the DT cord-023095-4dannjjm 2083 27 peak peak JJ cord-023095-4dannjjm 2083 28 post post JJ cord-023095-4dannjjm 2083 29 - - JJ cord-023095-4dannjjm 2083 30 ACTH acth JJ cord-023095-4dannjjm 2083 31 concentration concentration NN cord-023095-4dannjjm 2083 32 for for IN cord-023095-4dannjjm 2083 33 each each DT cord-023095-4dannjjm 2083 34 hormone hormone NN cord-023095-4dannjjm 2083 35 , , , cord-023095-4dannjjm 2083 36 but but CC cord-023095-4dannjjm 2083 37 not not RB cord-023095-4dannjjm 2083 38 in in IN cord-023095-4dannjjm 2083 39 dogs dog NNS cord-023095-4dannjjm 2083 40 treated treat VBN cord-023095-4dannjjm 2083 41 with with IN cord-023095-4dannjjm 2083 42 mitotane mitotane NNP cord-023095-4dannjjm 2083 43 . . . cord-023095-4dannjjm 2084 1 Basal basal NN cord-023095-4dannjjm 2084 2 serum serum NN cord-023095-4dannjjm 2084 3 sodium sodium NN cord-023095-4dannjjm 2084 4 and and CC cord-023095-4dannjjm 2084 5 potassium potassium NN cord-023095-4dannjjm 2084 6 concentrations concentration NNS cord-023095-4dannjjm 2084 7 were be VBD cord-023095-4dannjjm 2084 8 not not RB cord-023095-4dannjjm 2084 9 correlated correlate VBN cord-023095-4dannjjm 2084 10 with with IN cord-023095-4dannjjm 2084 11 the the DT cord-023095-4dannjjm 2084 12 basal basal NN cord-023095-4dannjjm 2084 13 aldosterone aldosterone NN cord-023095-4dannjjm 2084 14 concentration concentration NN cord-023095-4dannjjm 2084 15 in in IN cord-023095-4dannjjm 2084 16 either either DT cord-023095-4dannjjm 2084 17 treatment treatment NN cord-023095-4dannjjm 2084 18 group group NN cord-023095-4dannjjm 2084 19 . . . cord-023095-4dannjjm 2085 1 In in IN cord-023095-4dannjjm 2085 2 conclusion conclusion NN cord-023095-4dannjjm 2085 3 , , , cord-023095-4dannjjm 2085 4 treatment treatment NN cord-023095-4dannjjm 2085 5 with with IN cord-023095-4dannjjm 2085 6 mitotane mitotane NNP cord-023095-4dannjjm 2085 7 resulted result VBD cord-023095-4dannjjm 2085 8 in in IN cord-023095-4dannjjm 2085 9 decreased decrease VBN cord-023095-4dannjjm 2085 10 aldosterone aldosterone NN cord-023095-4dannjjm 2085 11 secretory secretory NN cord-023095-4dannjjm 2085 12 reserve reserve NN cord-023095-4dannjjm 2085 13 , , , cord-023095-4dannjjm 2085 14 but but CC cord-023095-4dannjjm 2085 15 this this DT cord-023095-4dannjjm 2085 16 did do VBD cord-023095-4dannjjm 2085 17 not not RB cord-023095-4dannjjm 2085 18 correlate correlate VB cord-023095-4dannjjm 2085 19 with with IN cord-023095-4dannjjm 2085 20 hyperkalemia hyperkalemia NN cord-023095-4dannjjm 2085 21 or or CC cord-023095-4dannjjm 2085 22 hyponatremia hyponatremia NN cord-023095-4dannjjm 2085 23 . . . cord-023095-4dannjjm 2086 1 Measurement measurement NN cord-023095-4dannjjm 2086 2 of of IN cord-023095-4dannjjm 2086 3 aldosterone aldosterone NN cord-023095-4dannjjm 2086 4 concentrations concentration NNS cord-023095-4dannjjm 2086 5 is be VBZ cord-023095-4dannjjm 2086 6 not not RB cord-023095-4dannjjm 2086 7 predictive predictive JJ cord-023095-4dannjjm 2086 8 of of IN cord-023095-4dannjjm 2086 9 electrolyte electrolyte JJ cord-023095-4dannjjm 2086 10 concentrations concentration NNS cord-023095-4dannjjm 2086 11 . . . cord-023095-4dannjjm 2087 1 Previously previously RB cord-023095-4dannjjm 2087 2 presented present VBN cord-023095-4dannjjm 2087 3 at at IN cord-023095-4dannjjm 2087 4 the the DT cord-023095-4dannjjm 2087 5 Auburn Auburn NNP cord-023095-4dannjjm 2087 6 University University NNP cord-023095-4dannjjm 2087 7 Phi Phi NNP cord-023095-4dannjjm 2087 8 Zeta Zeta NNP cord-023095-4dannjjm 2087 9 Research Research NNP cord-023095-4dannjjm 2087 10 Emphasis Emphasis NNP cord-023095-4dannjjm 2087 11 Day Day NNP cord-023095-4dannjjm 2087 12 , , , cord-023095-4dannjjm 2087 13 November November NNP cord-023095-4dannjjm 2087 14 10 10 CD cord-023095-4dannjjm 2087 15 , , , cord-023095-4dannjjm 2087 16 2010 2010 CD cord-023095-4dannjjm 2087 17 . . . cord-023095-4dannjjm 2088 1 Antioxidant antioxidant JJ cord-023095-4dannjjm 2088 2 depletion depletion NN cord-023095-4dannjjm 2088 3 is be VBZ cord-023095-4dannjjm 2088 4 documented document VBN cord-023095-4dannjjm 2088 5 in in IN cord-023095-4dannjjm 2088 6 humans human NNS cord-023095-4dannjjm 2088 7 with with IN cord-023095-4dannjjm 2088 8 hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 2088 9 , , , cord-023095-4dannjjm 2088 10 and and CC cord-023095-4dannjjm 2088 11 is be VBZ cord-023095-4dannjjm 2088 12 reversible reversible JJ cord-023095-4dannjjm 2088 13 with with IN cord-023095-4dannjjm 2088 14 treatment treatment NN cord-023095-4dannjjm 2088 15 . . . cord-023095-4dannjjm 2089 1 In in IN cord-023095-4dannjjm 2089 2 addition addition NN cord-023095-4dannjjm 2089 3 , , , cord-023095-4dannjjm 2089 4 antioxidant antioxidant JJ cord-023095-4dannjjm 2089 5 depletion depletion NN cord-023095-4dannjjm 2089 6 has have VBZ cord-023095-4dannjjm 2089 7 been be VBN cord-023095-4dannjjm 2089 8 shown show VBN cord-023095-4dannjjm 2089 9 to to TO cord-023095-4dannjjm 2089 10 increase increase VB cord-023095-4dannjjm 2089 11 the the DT cord-023095-4dannjjm 2089 12 risk risk NN cord-023095-4dannjjm 2089 13 of of IN cord-023095-4dannjjm 2089 14 methimazole methimazole NN cord-023095-4dannjjm 2089 15 toxicity toxicity NN cord-023095-4dannjjm 2089 16 in in IN cord-023095-4dannjjm 2089 17 rats rat NNS cord-023095-4dannjjm 2089 18 . . . cord-023095-4dannjjm 2090 1 The the DT cord-023095-4dannjjm 2090 2 primary primary JJ cord-023095-4dannjjm 2090 3 aim aim NN cord-023095-4dannjjm 2090 4 of of IN cord-023095-4dannjjm 2090 5 this this DT cord-023095-4dannjjm 2090 6 study study NN cord-023095-4dannjjm 2090 7 was be VBD cord-023095-4dannjjm 2090 8 to to TO cord-023095-4dannjjm 2090 9 determine determine VB cord-023095-4dannjjm 2090 10 whether whether IN cord-023095-4dannjjm 2090 11 deficiencies deficiency NNS cord-023095-4dannjjm 2090 12 in in IN cord-023095-4dannjjm 2090 13 glutathione glutathione NN cord-023095-4dannjjm 2090 14 ( ( -LRB- cord-023095-4dannjjm 2090 15 GSH GSH NNP cord-023095-4dannjjm 2090 16 ) ) -RRB- cord-023095-4dannjjm 2090 17 , , , cord-023095-4dannjjm 2090 18 ascorbate ascorbate NNP cord-023095-4dannjjm 2090 19 ( ( -LRB- cord-023095-4dannjjm 2090 20 AA AA NNP cord-023095-4dannjjm 2090 21 ) ) -RRB- cord-023095-4dannjjm 2090 22 , , , cord-023095-4dannjjm 2090 23 or or CC cord-023095-4dannjjm 2090 24 vitamin vitamin NN cord-023095-4dannjjm 2090 25 E e NN cord-023095-4dannjjm 2090 26 , , , cord-023095-4dannjjm 2090 27 along along IN cord-023095-4dannjjm 2090 28 with with IN cord-023095-4dannjjm 2090 29 increases increase NNS cord-023095-4dannjjm 2090 30 in in IN cord-023095-4dannjjm 2090 31 urinary urinary JJ cord-023095-4dannjjm 2090 32 8-isoprostanes 8-isoprostanes CD cord-023095-4dannjjm 2090 33 , , , cord-023095-4dannjjm 2090 34 were be VBD cord-023095-4dannjjm 2090 35 present present JJ cord-023095-4dannjjm 2090 36 in in IN cord-023095-4dannjjm 2090 37 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 2090 38 cats cat NNS cord-023095-4dannjjm 2090 39 , , , cord-023095-4dannjjm 2090 40 and and CC cord-023095-4dannjjm 2090 41 were be VBD cord-023095-4dannjjm 2090 42 reversible reversible JJ cord-023095-4dannjjm 2090 43 after after IN cord-023095-4dannjjm 2090 44 radioiodine radioiodine NN cord-023095-4dannjjm 2090 45 treatment treatment NN cord-023095-4dannjjm 2090 46 . . . cord-023095-4dannjjm 2091 1 A a DT cord-023095-4dannjjm 2091 2 secondary secondary JJ cord-023095-4dannjjm 2091 3 aim aim NN cord-023095-4dannjjm 2091 4 was be VBD cord-023095-4dannjjm 2091 5 to to TO cord-023095-4dannjjm 2091 6 determine determine VB cord-023095-4dannjjm 2091 7 whether whether IN cord-023095-4dannjjm 2091 8 antioxidant antioxidant JJ cord-023095-4dannjjm 2091 9 abnormalities abnormality NNS cord-023095-4dannjjm 2091 10 were be VBD cord-023095-4dannjjm 2091 11 associated associate VBN cord-023095-4dannjjm 2091 12 with with IN cord-023095-4dannjjm 2091 13 a a DT cord-023095-4dannjjm 2091 14 prior prior JJ cord-023095-4dannjjm 2091 15 history history NN cord-023095-4dannjjm 2091 16 of of IN cord-023095-4dannjjm 2091 17 methimazole methimazole NN cord-023095-4dannjjm 2091 18 toxicity toxicity NN cord-023095-4dannjjm 2091 19 . . . cord-023095-4dannjjm 2092 1 Ongoing ongoing JJ cord-023095-4dannjjm 2092 2 prospective prospective NN cord-023095-4dannjjm 2092 3 , , , cord-023095-4dannjjm 2092 4 controlled control VBN cord-023095-4dannjjm 2092 5 , , , cord-023095-4dannjjm 2092 6 observational observational JJ cord-023095-4dannjjm 2092 7 study study NN cord-023095-4dannjjm 2092 8 . . . cord-023095-4dannjjm 2093 1 Otherwise otherwise RB cord-023095-4dannjjm 2093 2 healthy healthy JJ cord-023095-4dannjjm 2093 3 client client NN cord-023095-4dannjjm 2093 4 - - HYPH cord-023095-4dannjjm 2093 5 owned own VBN cord-023095-4dannjjm 2093 6 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 2093 7 cats cat NNS cord-023095-4dannjjm 2093 8 presenting present VBG cord-023095-4dannjjm 2093 9 for for IN cord-023095-4dannjjm 2093 10 radioiodine radioiodine NN cord-023095-4dannjjm 2093 11 therapy therapy NN cord-023095-4dannjjm 2093 12 ( ( -LRB- cord-023095-4dannjjm 2093 13 n n NN cord-023095-4dannjjm 2093 14 5 5 CD cord-023095-4dannjjm 2093 15 26 26 CD cord-023095-4dannjjm 2093 16 to to IN cord-023095-4dannjjm 2093 17 date date NN cord-023095-4dannjjm 2093 18 ) ) -RRB- cord-023095-4dannjjm 2093 19 and and CC cord-023095-4dannjjm 2093 20 healthy healthy JJ cord-023095-4dannjjm 2093 21 age age NN cord-023095-4dannjjm 2093 22 - - HYPH cord-023095-4dannjjm 2093 23 matched match VBN cord-023095-4dannjjm 2093 24 controls control NNS cord-023095-4dannjjm 2093 25 ( ( -LRB- cord-023095-4dannjjm 2093 26 n n NN cord-023095-4dannjjm 2093 27 5 5 CD cord-023095-4dannjjm 2093 28 32 32 CD cord-023095-4dannjjm 2093 29 to to IN cord-023095-4dannjjm 2093 30 date date NN cord-023095-4dannjjm 2093 31 ) ) -RRB- cord-023095-4dannjjm 2093 32 were be VBD cord-023095-4dannjjm 2093 33 recruited recruit VBN cord-023095-4dannjjm 2093 34 . . . cord-023095-4dannjjm 2094 1 All all DT cord-023095-4dannjjm 2094 2 cats cat NNS cord-023095-4dannjjm 2094 3 were be VBD cord-023095-4dannjjm 2094 4 screened screen VBN cord-023095-4dannjjm 2094 5 with with IN cord-023095-4dannjjm 2094 6 CBC CBC NNP cord-023095-4dannjjm 2094 7 , , , cord-023095-4dannjjm 2094 8 biochemical biochemical JJ cord-023095-4dannjjm 2094 9 panel panel NN cord-023095-4dannjjm 2094 10 , , , cord-023095-4dannjjm 2094 11 urinalysis urinalysis NN cord-023095-4dannjjm 2094 12 , , , cord-023095-4dannjjm 2094 13 and and CC cord-023095-4dannjjm 2094 14 T4 T4 NNP cord-023095-4dannjjm 2094 15 , , , cord-023095-4dannjjm 2094 16 as as RB cord-023095-4dannjjm 2094 17 well well RB cord-023095-4dannjjm 2094 18 as as IN cord-023095-4dannjjm 2094 19 red red JJ cord-023095-4dannjjm 2094 20 blood blood NN cord-023095-4dannjjm 2094 21 cell cell NN cord-023095-4dannjjm 2094 22 ( ( -LRB- cord-023095-4dannjjm 2094 23 RBC RBC NNP cord-023095-4dannjjm 2094 24 ) ) -RRB- cord-023095-4dannjjm 2094 25 GSH GSH NNP cord-023095-4dannjjm 2094 26 , , , cord-023095-4dannjjm 2094 27 plasma plasma NN cord-023095-4dannjjm 2094 28 AA aa NN cord-023095-4dannjjm 2094 29 , , , cord-023095-4dannjjm 2094 30 plasma plasma NN cord-023095-4dannjjm 2094 31 vitamin vitamin NN cord-023095-4dannjjm 2094 32 E e NN cord-023095-4dannjjm 2094 33 , , , cord-023095-4dannjjm 2094 34 and and CC cord-023095-4dannjjm 2094 35 urinary urinary JJ cord-023095-4dannjjm 2094 36 8-isoprostanes 8-isoprostanes CD cord-023095-4dannjjm 2094 37 . . . cord-023095-4dannjjm 2095 1 Hyperthyroid Hyperthyroid NNP cord-023095-4dannjjm 2095 2 cats cat NNS cord-023095-4dannjjm 2095 3 were be VBD cord-023095-4dannjjm 2095 4 re re VBN cord-023095-4dannjjm 2095 5 - - VBN cord-023095-4dannjjm 2095 6 evaluated evaluate VBN cord-023095-4dannjjm 2095 7 2 2 CD cord-023095-4dannjjm 2095 8 months month NNS cord-023095-4dannjjm 2095 9 after after IN cord-023095-4dannjjm 2095 10 radioiodine radioiodine NN cord-023095-4dannjjm 2095 11 treatment treatment NN cord-023095-4dannjjm 2095 12 . . . cord-023095-4dannjjm 2096 1 Unlike unlike IN cord-023095-4dannjjm 2096 2 in in IN cord-023095-4dannjjm 2096 3 humans human NNS cord-023095-4dannjjm 2096 4 , , , cord-023095-4dannjjm 2096 5 median median JJ cord-023095-4dannjjm 2096 6 blood blood NN cord-023095-4dannjjm 2096 7 antioxidants antioxidant NNS cord-023095-4dannjjm 2096 8 were be VBD cord-023095-4dannjjm 2096 9 not not RB cord-023095-4dannjjm 2096 10 significantly significantly RB cord-023095-4dannjjm 2096 11 different different JJ cord-023095-4dannjjm 2096 12 in in IN cord-023095-4dannjjm 2096 13 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 2096 14 cats cat NNS cord-023095-4dannjjm 2096 15 ( ( -LRB- cord-023095-4dannjjm 2096 16 GSH GSH NNP cord-023095-4dannjjm 2096 17 1.5 1.5 CD cord-023095-4dannjjm 2096 18 mM mm CD cord-023095-4dannjjm 2096 19 ; ; : cord-023095-4dannjjm 2096 20 AA AA NNP cord-023095-4dannjjm 2096 21 11.4 11.4 CD cord-023095-4dannjjm 2096 22 mM mM NNP cord-023095-4dannjjm 2096 23 , , , cord-023095-4dannjjm 2096 24 and and CC cord-023095-4dannjjm 2096 25 vitamin vitamin NN cord-023095-4dannjjm 2096 26 E e NN cord-023095-4dannjjm 2096 27 , , , cord-023095-4dannjjm 2096 28 19 19 CD cord-023095-4dannjjm 2096 29 g g NN cord-023095-4dannjjm 2096 30 / / SYM cord-023095-4dannjjm 2096 31 ml ml NN cord-023095-4dannjjm 2096 32 ) ) -RRB- cord-023095-4dannjjm 2097 1 compared compare VBN cord-023095-4dannjjm 2097 2 to to IN cord-023095-4dannjjm 2097 3 controls control NNS cord-023095-4dannjjm 2097 4 ( ( -LRB- cord-023095-4dannjjm 2097 5 GSH GSH NNP cord-023095-4dannjjm 2097 6 1.4 1.4 CD cord-023095-4dannjjm 2097 7 mM mm CD cord-023095-4dannjjm 2097 8 ; ; : cord-023095-4dannjjm 2097 9 AA AA NNP cord-023095-4dannjjm 2097 10 12.5 12.5 CD cord-023095-4dannjjm 2097 11 mM mM NNP cord-023095-4dannjjm 2097 12 , , , cord-023095-4dannjjm 2097 13 and and CC cord-023095-4dannjjm 2097 14 vitamin vitamin NN cord-023095-4dannjjm 2097 15 E e NN cord-023095-4dannjjm 2097 16 , , , cord-023095-4dannjjm 2097 17 17 17 CD cord-023095-4dannjjm 2097 18 g g NN cord-023095-4dannjjm 2097 19 / / SYM cord-023095-4dannjjm 2097 20 ml ml NN cord-023095-4dannjjm 2097 21 ) ) -RRB- cord-023095-4dannjjm 2097 22 . . . cord-023095-4dannjjm 2098 1 Results result NNS cord-023095-4dannjjm 2098 2 for for IN cord-023095-4dannjjm 2098 3 urinary urinary JJ cord-023095-4dannjjm 2098 4 isoprostanes isoprostane NNS cord-023095-4dannjjm 2098 5 are be VBP cord-023095-4dannjjm 2098 6 pending pende VBG cord-023095-4dannjjm 2098 7 , , , cord-023095-4dannjjm 2098 8 and and CC cord-023095-4dannjjm 2098 9 associations association NNS cord-023095-4dannjjm 2098 10 with with IN cord-023095-4dannjjm 2098 11 methimazole methimazole NN cord-023095-4dannjjm 2098 12 toxicity toxicity NN cord-023095-4dannjjm 2098 13 will will MD cord-023095-4dannjjm 2098 14 be be VB cord-023095-4dannjjm 2098 15 investigated investigate VBN cord-023095-4dannjjm 2098 16 after after IN cord-023095-4dannjjm 2098 17 full full JJ cord-023095-4dannjjm 2098 18 recruitment recruitment NN cord-023095-4dannjjm 2098 19 . . . cord-023095-4dannjjm 2099 1 RBC RBC NNP cord-023095-4dannjjm 2099 2 GSH GSH NNP cord-023095-4dannjjm 2099 3 concentrations concentration NNS cord-023095-4dannjjm 2099 4 did do VBD cord-023095-4dannjjm 2099 5 increase increase VB cord-023095-4dannjjm 2099 6 significantly significantly RB cord-023095-4dannjjm 2099 7 ( ( -LRB- cord-023095-4dannjjm 2099 8 to to IN cord-023095-4dannjjm 2099 9 1.6 1.6 CD cord-023095-4dannjjm 2099 10 mM mm CD cord-023095-4dannjjm 2099 11 ; ; : cord-023095-4dannjjm 2099 12 P p NN cord-023095-4dannjjm 2099 13 5 5 CD cord-023095-4dannjjm 2099 14 0.019 0.019 CD cord-023095-4dannjjm 2099 15 ) ) -RRB- cord-023095-4dannjjm 2099 16 after after IN cord-023095-4dannjjm 2099 17 radioiodine radioiodine NN cord-023095-4dannjjm 2099 18 treatment treatment NN cord-023095-4dannjjm 2099 19 . . . cord-023095-4dannjjm 2100 1 However however RB cord-023095-4dannjjm 2100 2 , , , cord-023095-4dannjjm 2100 3 this this DT cord-023095-4dannjjm 2100 4 modest modest JJ cord-023095-4dannjjm 2100 5 change change NN cord-023095-4dannjjm 2100 6 is be VBZ cord-023095-4dannjjm 2100 7 unlikely unlikely JJ cord-023095-4dannjjm 2100 8 to to TO cord-023095-4dannjjm 2100 9 be be VB cord-023095-4dannjjm 2100 10 clinically clinically RB cord-023095-4dannjjm 2100 11 significant significant JJ cord-023095-4dannjjm 2100 12 . . . cord-023095-4dannjjm 2101 1 Preliminary preliminary JJ cord-023095-4dannjjm 2101 2 data datum NNS cord-023095-4dannjjm 2101 3 do do VBP cord-023095-4dannjjm 2101 4 not not RB cord-023095-4dannjjm 2101 5 indicate indicate VB cord-023095-4dannjjm 2101 6 clinically clinically RB cord-023095-4dannjjm 2101 7 significant significant JJ cord-023095-4dannjjm 2101 8 blood blood NN cord-023095-4dannjjm 2101 9 GSH GSH NNP cord-023095-4dannjjm 2101 10 , , , cord-023095-4dannjjm 2101 11 ascorbate ascorbate NN cord-023095-4dannjjm 2101 12 , , , cord-023095-4dannjjm 2101 13 or or CC cord-023095-4dannjjm 2101 14 vitamin vitamin NN cord-023095-4dannjjm 2101 15 E e NN cord-023095-4dannjjm 2101 16 deficiencies deficiency NNS cord-023095-4dannjjm 2101 17 in in IN cord-023095-4dannjjm 2101 18 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 2101 19 cats cat NNS cord-023095-4dannjjm 2101 20 . . . cord-023095-4dannjjm 2102 1 With with IN cord-023095-4dannjjm 2102 2 appropriate appropriate JJ cord-023095-4dannjjm 2102 3 insulin insulin NN cord-023095-4dannjjm 2102 4 therapy therapy NN cord-023095-4dannjjm 2102 5 and and CC cord-023095-4dannjjm 2102 6 a a DT cord-023095-4dannjjm 2102 7 low low JJ cord-023095-4dannjjm 2102 8 carbohydrate carbohydrate NN cord-023095-4dannjjm 2102 9 diet diet NN cord-023095-4dannjjm 2102 10 , , , cord-023095-4dannjjm 2102 11 up up IN cord-023095-4dannjjm 2102 12 to to TO cord-023095-4dannjjm 2102 13 90 90 CD cord-023095-4dannjjm 2102 14 % % NN cord-023095-4dannjjm 2102 15 of of IN cord-023095-4dannjjm 2102 16 newly newly RB cord-023095-4dannjjm 2102 17 diagnosed diagnose VBN cord-023095-4dannjjm 2102 18 diabetic diabetic JJ cord-023095-4dannjjm 2102 19 cats cat NNS cord-023095-4dannjjm 2102 20 are be VBP cord-023095-4dannjjm 2102 21 eventually eventually RB cord-023095-4dannjjm 2102 22 able able JJ cord-023095-4dannjjm 2102 23 to to TO cord-023095-4dannjjm 2102 24 maintain maintain VB cord-023095-4dannjjm 2102 25 euglycemia euglycemia NN cord-023095-4dannjjm 2102 26 without without IN cord-023095-4dannjjm 2102 27 insulin insulin NN cord-023095-4dannjjm 2102 28 administration administration NN cord-023095-4dannjjm 2102 29 , , , cord-023095-4dannjjm 2102 30 and and CC cord-023095-4dannjjm 2102 31 these these DT cord-023095-4dannjjm 2102 32 cats cat NNS cord-023095-4dannjjm 2102 33 are be VBP cord-023095-4dannjjm 2102 34 considered consider VBN cord-023095-4dannjjm 2102 35 to to TO cord-023095-4dannjjm 2102 36 have have VB cord-023095-4dannjjm 2102 37 achieved achieve VBN cord-023095-4dannjjm 2102 38 remission remission NN cord-023095-4dannjjm 2102 39 . . . cord-023095-4dannjjm 2103 1 There there EX cord-023095-4dannjjm 2103 2 are be VBP cord-023095-4dannjjm 2103 3 currently currently RB cord-023095-4dannjjm 2103 4 no no DT cord-023095-4dannjjm 2103 5 published publish VBN cord-023095-4dannjjm 2103 6 data datum NNS cord-023095-4dannjjm 2103 7 reporting report VBG cord-023095-4dannjjm 2103 8 the the DT cord-023095-4dannjjm 2103 9 glucose glucose NN cord-023095-4dannjjm 2103 10 tolerance tolerance NN cord-023095-4dannjjm 2103 11 status status NN cord-023095-4dannjjm 2103 12 of of IN cord-023095-4dannjjm 2103 13 cats cat NNS cord-023095-4dannjjm 2103 14 classified classify VBN cord-023095-4dannjjm 2103 15 as as IN cord-023095-4dannjjm 2103 16 being be VBG cord-023095-4dannjjm 2103 17 in in IN cord-023095-4dannjjm 2103 18 remission remission NN cord-023095-4dannjjm 2103 19 , , , cord-023095-4dannjjm 2103 20 and and CC cord-023095-4dannjjm 2103 21 it -PRON- PRP cord-023095-4dannjjm 2103 22 is be VBZ cord-023095-4dannjjm 2103 23 unknown unknown JJ cord-023095-4dannjjm 2103 24 whether whether IN cord-023095-4dannjjm 2103 25 these these DT cord-023095-4dannjjm 2103 26 cats cat NNS cord-023095-4dannjjm 2103 27 are be VBP cord-023095-4dannjjm 2103 28 truly truly RB cord-023095-4dannjjm 2103 29 in in IN cord-023095-4dannjjm 2103 30 diabetic diabetic JJ cord-023095-4dannjjm 2103 31 remission remission NN cord-023095-4dannjjm 2103 32 , , , cord-023095-4dannjjm 2103 33 or or CC cord-023095-4dannjjm 2103 34 should should MD cord-023095-4dannjjm 2103 35 be be VB cord-023095-4dannjjm 2103 36 classified classify VBN cord-023095-4dannjjm 2103 37 as as IN cord-023095-4dannjjm 2103 38 non non JJ cord-023095-4dannjjm 2103 39 - - JJ cord-023095-4dannjjm 2103 40 insulin insulin JJ cord-023095-4dannjjm 2103 41 dependent dependent JJ cord-023095-4dannjjm 2103 42 diabetics diabetic NNS cord-023095-4dannjjm 2103 43 , , , cord-023095-4dannjjm 2103 44 or or CC cord-023095-4dannjjm 2103 45 having have VBG cord-023095-4dannjjm 2103 46 impaired impair VBN cord-023095-4dannjjm 2103 47 glucose glucose NN cord-023095-4dannjjm 2103 48 tolerance tolerance NN cord-023095-4dannjjm 2103 49 , , , cord-023095-4dannjjm 2103 50 and/or and/or CC cord-023095-4dannjjm 2103 51 impaired impaired JJ cord-023095-4dannjjm 2103 52 fasting fast VBG cord-023095-4dannjjm 2103 53 blood blood NN cord-023095-4dannjjm 2103 54 glucose glucose NN cord-023095-4dannjjm 2103 55 . . . cord-023095-4dannjjm 2104 1 The the DT cord-023095-4dannjjm 2104 2 aim aim NN cord-023095-4dannjjm 2104 3 of of IN cord-023095-4dannjjm 2104 4 this this DT cord-023095-4dannjjm 2104 5 study study NN cord-023095-4dannjjm 2104 6 was be VBD cord-023095-4dannjjm 2104 7 to to TO cord-023095-4dannjjm 2104 8 determine determine VB cord-023095-4dannjjm 2104 9 fasting fast VBG cord-023095-4dannjjm 2104 10 blood blood NN cord-023095-4dannjjm 2104 11 glucose glucose NN cord-023095-4dannjjm 2104 12 concentrations concentration NNS cord-023095-4dannjjm 2104 13 and and CC cord-023095-4dannjjm 2104 14 glucose glucose NN cord-023095-4dannjjm 2104 15 tolerance tolerance NN cord-023095-4dannjjm 2104 16 status status NN cord-023095-4dannjjm 2104 17 of of IN cord-023095-4dannjjm 2104 18 cats cat NNS cord-023095-4dannjjm 2104 19 in in IN cord-023095-4dannjjm 2104 20 remission remission NN cord-023095-4dannjjm 2104 21 . . . cord-023095-4dannjjm 2105 1 The the DT cord-023095-4dannjjm 2105 2 study study NN cord-023095-4dannjjm 2105 3 was be VBD cord-023095-4dannjjm 2105 4 a a DT cord-023095-4dannjjm 2105 5 prospective prospective JJ cord-023095-4dannjjm 2105 6 study study NN cord-023095-4dannjjm 2105 7 in in IN cord-023095-4dannjjm 2105 8 a a DT cord-023095-4dannjjm 2105 9 feline feline JJ cord-023095-4dannjjm 2105 10 - - HYPH cord-023095-4dannjjm 2105 11 only only JJ cord-023095-4dannjjm 2105 12 clinic clinic NN cord-023095-4dannjjm 2105 13 . . . cord-023095-4dannjjm 2106 1 For for IN cord-023095-4dannjjm 2106 2 inclusion inclusion NN cord-023095-4dannjjm 2106 3 , , , cord-023095-4dannjjm 2106 4 diabetic diabetic JJ cord-023095-4dannjjm 2106 5 cats cat NNS cord-023095-4dannjjm 2106 6 had have VBD cord-023095-4dannjjm 2106 7 to to TO cord-023095-4dannjjm 2106 8 have have VB cord-023095-4dannjjm 2106 9 achieved achieve VBN cord-023095-4dannjjm 2106 10 remission remission NN cord-023095-4dannjjm 2106 11 through through IN cord-023095-4dannjjm 2106 12 insulin insulin NN cord-023095-4dannjjm 2106 13 therapy therapy NN cord-023095-4dannjjm 2106 14 , , , cord-023095-4dannjjm 2106 15 and and CC cord-023095-4dannjjm 2106 16 insulin insulin NN cord-023095-4dannjjm 2106 17 withheld withhold VBN cord-023095-4dannjjm 2106 18 for for IN cord-023095-4dannjjm 2106 19 a a DT cord-023095-4dannjjm 2106 20 minimum minimum NN cord-023095-4dannjjm 2106 21 of of IN cord-023095-4dannjjm 2106 22 two two CD cord-023095-4dannjjm 2106 23 weeks week NNS cord-023095-4dannjjm 2106 24 . . . cord-023095-4dannjjm 2107 1 Five five CD cord-023095-4dannjjm 2107 2 diabetic diabetic JJ cord-023095-4dannjjm 2107 3 cats cat NNS cord-023095-4dannjjm 2107 4 in in IN cord-023095-4dannjjm 2107 5 remission remission NN cord-023095-4dannjjm 2107 6 and and CC cord-023095-4dannjjm 2107 7 five five CD cord-023095-4dannjjm 2107 8 matched match VBN cord-023095-4dannjjm 2107 9 non non JJ cord-023095-4dannjjm 2107 10 - - JJ cord-023095-4dannjjm 2107 11 diabetic diabetic JJ cord-023095-4dannjjm 2107 12 cats cat NNS cord-023095-4dannjjm 2107 13 were be VBD cord-023095-4dannjjm 2107 14 enrolled enrol VBN cord-023095-4dannjjm 2107 15 in in IN cord-023095-4dannjjm 2107 16 the the DT cord-023095-4dannjjm 2107 17 study study NN cord-023095-4dannjjm 2107 18 . . . cord-023095-4dannjjm 2108 1 Blood blood NN cord-023095-4dannjjm 2108 2 samples sample NNS cord-023095-4dannjjm 2108 3 were be VBD cord-023095-4dannjjm 2108 4 obtained obtain VBN cord-023095-4dannjjm 2108 5 via via IN cord-023095-4dannjjm 2108 6 the the DT cord-023095-4dannjjm 2108 7 ear ear NN cord-023095-4dannjjm 2108 8 vein vein NN cord-023095-4dannjjm 2108 9 but but CC cord-023095-4dannjjm 2108 10 where where WRB cord-023095-4dannjjm 2108 11 the the DT cord-023095-4dannjjm 2108 12 cat cat NN cord-023095-4dannjjm 2108 13 's 's POS cord-023095-4dannjjm 2108 14 temperament temperament NN cord-023095-4dannjjm 2108 15 precluded preclude VBD cord-023095-4dannjjm 2108 16 this this DT cord-023095-4dannjjm 2108 17 , , , cord-023095-4dannjjm 2108 18 from from IN cord-023095-4dannjjm 2108 19 the the DT cord-023095-4dannjjm 2108 20 jugular jugular NN cord-023095-4dannjjm 2108 21 . . . cord-023095-4dannjjm 2109 1 Glucose glucose NN cord-023095-4dannjjm 2109 2 concentration concentration NN cord-023095-4dannjjm 2109 3 was be VBD cord-023095-4dannjjm 2109 4 measured measure VBN cord-023095-4dannjjm 2109 5 using use VBG cord-023095-4dannjjm 2109 6 a a DT cord-023095-4dannjjm 2109 7 meter meter NN cord-023095-4dannjjm 2109 8 calibrated calibrate VBN cord-023095-4dannjjm 2109 9 for for IN cord-023095-4dannjjm 2109 10 feline feline JJ cord-023095-4dannjjm 2109 11 blood blood NN cord-023095-4dannjjm 2110 1 ( ( -LRB- cord-023095-4dannjjm 2110 2 Abbott Abbott NNP cord-023095-4dannjjm 2110 3 AlphaTRAK AlphaTRAK NNP cord-023095-4dannjjm 2110 4 ) ) -RRB- cord-023095-4dannjjm 2110 5 . . . cord-023095-4dannjjm 2111 1 A a DT cord-023095-4dannjjm 2111 2 simplified simplified JJ cord-023095-4dannjjm 2111 3 glucose glucose NN cord-023095-4dannjjm 2111 4 tolerance tolerance NN cord-023095-4dannjjm 2111 5 test test NN cord-023095-4dannjjm 2111 6 was be VBD cord-023095-4dannjjm 2111 7 performed perform VBN cord-023095-4dannjjm 2111 8 after after IN cord-023095-4dannjjm 2111 9 food food NN cord-023095-4dannjjm 2111 10 was be VBD cord-023095-4dannjjm 2111 11 withheld withhold VBN cord-023095-4dannjjm 2111 12 for for IN cord-023095-4dannjjm 2111 13 24 24 CD cord-023095-4dannjjm 2111 14 hours hour NNS cord-023095-4dannjjm 2111 15 . . . cord-023095-4dannjjm 2112 1 A a DT cord-023095-4dannjjm 2112 2 22 22 CD cord-023095-4dannjjm 2112 3 G g NN cord-023095-4dannjjm 2112 4 catheter catheter NN cord-023095-4dannjjm 2112 5 was be VBD cord-023095-4dannjjm 2112 6 placed place VBN cord-023095-4dannjjm 2112 7 in in IN cord-023095-4dannjjm 2112 8 a a DT cord-023095-4dannjjm 2112 9 cephalic cephalic JJ cord-023095-4dannjjm 2112 10 vein vein NN cord-023095-4dannjjm 2112 11 three three CD cord-023095-4dannjjm 2112 12 hours hour NNS cord-023095-4dannjjm 2112 13 before before IN cord-023095-4dannjjm 2112 14 the the DT cord-023095-4dannjjm 2112 15 GTT GTT NNP cord-023095-4dannjjm 2112 16 was be VBD cord-023095-4dannjjm 2112 17 commenced commence VBN cord-023095-4dannjjm 2112 18 , , , cord-023095-4dannjjm 2112 19 to to TO cord-023095-4dannjjm 2112 20 minimize minimize VB cord-023095-4dannjjm 2112 21 the the DT cord-023095-4dannjjm 2112 22 effects effect NNS cord-023095-4dannjjm 2112 23 of of IN cord-023095-4dannjjm 2112 24 stress stress NN cord-023095-4dannjjm 2112 25 on on IN cord-023095-4dannjjm 2112 26 blood blood NN cord-023095-4dannjjm 2112 27 glucose glucose NN cord-023095-4dannjjm 2112 28 concentration concentration NN cord-023095-4dannjjm 2112 29 . . . cord-023095-4dannjjm 2113 1 Blood blood NN cord-023095-4dannjjm 2113 2 glucose glucose NN cord-023095-4dannjjm 2113 3 concentration concentration NN cord-023095-4dannjjm 2113 4 was be VBD cord-023095-4dannjjm 2113 5 measured measure VBN cord-023095-4dannjjm 2113 6 at at IN cord-023095-4dannjjm 2113 7 time time NN cord-023095-4dannjjm 2113 8 0 0 NFP cord-023095-4dannjjm 2113 9 and and CC cord-023095-4dannjjm 2113 10 then then RB cord-023095-4dannjjm 2113 11 a a DT cord-023095-4dannjjm 2113 12 1 1 CD cord-023095-4dannjjm 2113 13 g g NN cord-023095-4dannjjm 2113 14 / / SYM cord-023095-4dannjjm 2113 15 kg kg NN cord-023095-4dannjjm 2113 16 dose dose NN cord-023095-4dannjjm 2113 17 of of IN cord-023095-4dannjjm 2113 18 glucose glucose NN cord-023095-4dannjjm 2113 19 was be VBD cord-023095-4dannjjm 2113 20 administered administer VBN cord-023095-4dannjjm 2113 21 slowly slowly RB cord-023095-4dannjjm 2113 22 via via IN cord-023095-4dannjjm 2113 23 the the DT cord-023095-4dannjjm 2113 24 intravenous intravenous JJ cord-023095-4dannjjm 2113 25 catheter catheter NN cord-023095-4dannjjm 2113 26 . . . cord-023095-4dannjjm 2114 1 Further further JJ cord-023095-4dannjjm 2114 2 blood blood NN cord-023095-4dannjjm 2114 3 glucose glucose NN cord-023095-4dannjjm 2114 4 measurements measurement NNS cord-023095-4dannjjm 2114 5 were be VBD cord-023095-4dannjjm 2114 6 made make VBN cord-023095-4dannjjm 2114 7 at at IN cord-023095-4dannjjm 2114 8 2 2 CD cord-023095-4dannjjm 2114 9 hours hour NNS cord-023095-4dannjjm 2114 10 and and CC cord-023095-4dannjjm 2114 11 then then RB cord-023095-4dannjjm 2114 12 hourly hourly RB cord-023095-4dannjjm 2114 13 until until IN cord-023095-4dannjjm 2114 14 glucose glucose NN cord-023095-4dannjjm 2114 15 had have VBD cord-023095-4dannjjm 2114 16 returned return VBN cord-023095-4dannjjm 2114 17 to to IN cord-023095-4dannjjm 2114 18 o o CD cord-023095-4dannjjm 2114 19 117 117 CD cord-023095-4dannjjm 2114 20 mg mg NNP cord-023095-4dannjjm 2114 21 / / SYM cord-023095-4dannjjm 2114 22 dL dl NN cord-023095-4dannjjm 2115 1 ( ( -LRB- cord-023095-4dannjjm 2115 2 o o UH cord-023095-4dannjjm 2115 3 6.5 6.5 CD cord-023095-4dannjjm 2115 4 mmol mmol NNP cord-023095-4dannjjm 2115 5 / / SYM cord-023095-4dannjjm 2115 6 L L NNP cord-023095-4dannjjm 2115 7 ) ) -RRB- cord-023095-4dannjjm 2115 8 . . . cord-023095-4dannjjm 2116 1 In in IN cord-023095-4dannjjm 2116 2 the the DT cord-023095-4dannjjm 2116 3 control control NN cord-023095-4dannjjm 2116 4 group group NN cord-023095-4dannjjm 2116 5 , , , cord-023095-4dannjjm 2116 6 all all DT cord-023095-4dannjjm 2116 7 cats cat NNS cord-023095-4dannjjm 2116 8 had have VBD cord-023095-4dannjjm 2116 9 a a DT cord-023095-4dannjjm 2116 10 fasting fast VBG cord-023095-4dannjjm 2116 11 blood blood NN cord-023095-4dannjjm 2116 12 glucose glucose NN cord-023095-4dannjjm 2116 13 below below IN cord-023095-4dannjjm 2116 14 117 117 CD cord-023095-4dannjjm 2116 15 mg mg NNP cord-023095-4dannjjm 2116 16 / / SYM cord-023095-4dannjjm 2116 17 dL dl NN cord-023095-4dannjjm 2116 18 , , , cord-023095-4dannjjm 2116 19 and and CC cord-023095-4dannjjm 2116 20 following follow VBG cord-023095-4dannjjm 2116 21 glucose glucose NN cord-023095-4dannjjm 2116 22 administration administration NN cord-023095-4dannjjm 2116 23 , , , cord-023095-4dannjjm 2116 24 glucose glucose NN cord-023095-4dannjjm 2116 25 had have VBD cord-023095-4dannjjm 2116 26 returned return VBN cord-023095-4dannjjm 2116 27 to to IN cord-023095-4dannjjm 2116 28 o o NN cord-023095-4dannjjm 2117 1 117 117 CD cord-023095-4dannjjm 2117 2 mg mg NNP cord-023095-4dannjjm 2117 3 / / SYM cord-023095-4dannjjm 2117 4 dL dl NN cord-023095-4dannjjm 2117 5 by by IN cord-023095-4dannjjm 2117 6 3 3 CD cord-023095-4dannjjm 2117 7 hours hour NNS cord-023095-4dannjjm 2117 8 . . . cord-023095-4dannjjm 2118 1 Fasting fast VBG cord-023095-4dannjjm 2118 2 blood blood NN cord-023095-4dannjjm 2118 3 glucose glucose NN cord-023095-4dannjjm 2118 4 in in IN cord-023095-4dannjjm 2118 5 the the DT cord-023095-4dannjjm 2118 6 remission remission NN cord-023095-4dannjjm 2118 7 group group NN cord-023095-4dannjjm 2118 8 was be VBD cord-023095-4dannjjm 2118 9 o o UH cord-023095-4dannjjm 2119 1 126 126 CD cord-023095-4dannjjm 2119 2 mg mg NNP cord-023095-4dannjjm 2119 3 / / SYM cord-023095-4dannjjm 2119 4 dL dl NN cord-023095-4dannjjm 2119 5 ( ( -LRB- cord-023095-4dannjjm 2119 6 7 7 CD cord-023095-4dannjjm 2119 7 mmol mmol NNP cord-023095-4dannjjm 2119 8 / / SYM cord-023095-4dannjjm 2119 9 L L NNP cord-023095-4dannjjm 2119 10 ) ) -RRB- cord-023095-4dannjjm 2119 11 in in IN cord-023095-4dannjjm 2119 12 all all DT cord-023095-4dannjjm 2119 13 cats cat NNS cord-023095-4dannjjm 2119 14 except except IN cord-023095-4dannjjm 2119 15 one one CD cord-023095-4dannjjm 2119 16 , , , cord-023095-4dannjjm 2119 17 which which WDT cord-023095-4dannjjm 2119 18 had have VBD cord-023095-4dannjjm 2119 19 fasting fast VBG cord-023095-4dannjjm 2119 20 blood blood NN cord-023095-4dannjjm 2119 21 glucose glucose NN cord-023095-4dannjjm 2119 22 of of IN cord-023095-4dannjjm 2119 23 135 135 CD cord-023095-4dannjjm 2119 24 mg mg NNP cord-023095-4dannjjm 2119 25 / / SYM cord-023095-4dannjjm 2119 26 dL dl NN cord-023095-4dannjjm 2119 27 ( ( -LRB- cord-023095-4dannjjm 2119 28 7.5 7.5 CD cord-023095-4dannjjm 2119 29 mmol mmol JJ cord-023095-4dannjjm 2119 30 / / SYM cord-023095-4dannjjm 2119 31 L L NNP cord-023095-4dannjjm 2119 32 ) ) -RRB- cord-023095-4dannjjm 2119 33 . . . cord-023095-4dannjjm 2120 1 Following follow VBG cord-023095-4dannjjm 2120 2 glucose glucose NN cord-023095-4dannjjm 2120 3 administration administration NN cord-023095-4dannjjm 2120 4 , , , cord-023095-4dannjjm 2120 5 all all DT cord-023095-4dannjjm 2120 6 five five CD cord-023095-4dannjjm 2120 7 cats cat NNS cord-023095-4dannjjm 2120 8 in in IN cord-023095-4dannjjm 2120 9 remission remission NN cord-023095-4dannjjm 2120 10 had have VBD cord-023095-4dannjjm 2120 11 blood blood NN cord-023095-4dannjjm 2120 12 glucose glucose NN cord-023095-4dannjjm 2120 13 above above IN cord-023095-4dannjjm 2120 14 117 117 CD cord-023095-4dannjjm 2120 15 mg mg NNP cord-023095-4dannjjm 2120 16 / / SYM cord-023095-4dannjjm 2120 17 dL dl NN cord-023095-4dannjjm 2120 18 ( ( -LRB- cord-023095-4dannjjm 2120 19 6.5 6.5 CD cord-023095-4dannjjm 2120 20 mmol mmol JJ cord-023095-4dannjjm 2120 21 / / SYM cord-023095-4dannjjm 2120 22 L L NNP cord-023095-4dannjjm 2120 23 ) ) -RRB- cord-023095-4dannjjm 2120 24 at at IN cord-023095-4dannjjm 2120 25 three three CD cord-023095-4dannjjm 2120 26 hours hour NNS cord-023095-4dannjjm 2120 27 , , , cord-023095-4dannjjm 2120 28 four four CD cord-023095-4dannjjm 2120 29 were be VBD cord-023095-4dannjjm 2120 30 o o NN cord-023095-4dannjjm 2121 1 117 117 CD cord-023095-4dannjjm 2121 2 mg mg NNP cord-023095-4dannjjm 2121 3 / / SYM cord-023095-4dannjjm 2121 4 dL dl NN cord-023095-4dannjjm 2121 5 at at IN cord-023095-4dannjjm 2121 6 four four CD cord-023095-4dannjjm 2121 7 hours hour NNS cord-023095-4dannjjm 2121 8 , , , cord-023095-4dannjjm 2121 9 and and CC cord-023095-4dannjjm 2121 10 one one CD cord-023095-4dannjjm 2121 11 returned return VBD cord-023095-4dannjjm 2121 12 to to IN cord-023095-4dannjjm 2121 13 o o CD cord-023095-4dannjjm 2121 14 117 117 CD cord-023095-4dannjjm 2121 15 mg mg NNP cord-023095-4dannjjm 2121 16 / / SYM cord-023095-4dannjjm 2121 17 dL dl NN cord-023095-4dannjjm 2121 18 at at IN cord-023095-4dannjjm 2121 19 five five CD cord-023095-4dannjjm 2121 20 hours hour NNS cord-023095-4dannjjm 2121 21 . . . cord-023095-4dannjjm 2122 1 The the DT cord-023095-4dannjjm 2122 2 cat cat NN cord-023095-4dannjjm 2122 3 with with IN cord-023095-4dannjjm 2122 4 impaired impair VBN cord-023095-4dannjjm 2122 5 fasting fast VBG cord-023095-4dannjjm 2122 6 glucose glucose NN cord-023095-4dannjjm 2122 7 subsequently subsequently RB cord-023095-4dannjjm 2122 8 became become VBD cord-023095-4dannjjm 2122 9 diabetic diabetic JJ cord-023095-4dannjjm 2122 10 after after IN cord-023095-4dannjjm 2122 11 steroid steroid NNP cord-023095-4dannjjm 2122 12 administration administration NN cord-023095-4dannjjm 2122 13 . . . cord-023095-4dannjjm 2123 1 The the DT cord-023095-4dannjjm 2123 2 results result NNS cord-023095-4dannjjm 2123 3 of of IN cord-023095-4dannjjm 2123 4 this this DT cord-023095-4dannjjm 2123 5 study study NN cord-023095-4dannjjm 2123 6 show show VBP cord-023095-4dannjjm 2123 7 that that IN cord-023095-4dannjjm 2123 8 these these DT cord-023095-4dannjjm 2123 9 cats cat NNS cord-023095-4dannjjm 2123 10 , , , cord-023095-4dannjjm 2123 11 while while IN cord-023095-4dannjjm 2123 12 no no DT cord-023095-4dannjjm 2123 13 longer long RBR cord-023095-4dannjjm 2123 14 diabetic diabetic JJ cord-023095-4dannjjm 2123 15 , , , cord-023095-4dannjjm 2123 16 have have VBP cord-023095-4dannjjm 2123 17 mildly mildly RB cord-023095-4dannjjm 2123 18 impaired impair VBN cord-023095-4dannjjm 2123 19 glucose glucose NN cord-023095-4dannjjm 2123 20 tolerance tolerance NN cord-023095-4dannjjm 2123 21 compared compare VBN cord-023095-4dannjjm 2123 22 to to IN cord-023095-4dannjjm 2123 23 nondiabetic nondiabetic JJ cord-023095-4dannjjm 2123 24 cats cat NNS cord-023095-4dannjjm 2123 25 , , , cord-023095-4dannjjm 2123 26 and and CC cord-023095-4dannjjm 2123 27 a a DT cord-023095-4dannjjm 2123 28 minority minority NN cord-023095-4dannjjm 2123 29 have have VBP cord-023095-4dannjjm 2123 30 impaired impair VBN cord-023095-4dannjjm 2123 31 fasting fast VBG cord-023095-4dannjjm 2123 32 glucose glucose NN cord-023095-4dannjjm 2123 33 . . . cord-023095-4dannjjm 2124 1 The the DT cord-023095-4dannjjm 2124 2 objective objective NN cord-023095-4dannjjm 2124 3 of of IN cord-023095-4dannjjm 2124 4 this this DT cord-023095-4dannjjm 2124 5 study study NN cord-023095-4dannjjm 2124 6 was be VBD cord-023095-4dannjjm 2124 7 to to TO cord-023095-4dannjjm 2124 8 determine determine VB cord-023095-4dannjjm 2124 9 the the DT cord-023095-4dannjjm 2124 10 role role NN cord-023095-4dannjjm 2124 11 of of IN cord-023095-4dannjjm 2124 12 iodine iodine NN cord-023095-4dannjjm 2124 13 restriction restriction NN cord-023095-4dannjjm 2124 14 in in IN cord-023095-4dannjjm 2124 15 the the DT cord-023095-4dannjjm 2124 16 nutritional nutritional JJ cord-023095-4dannjjm 2124 17 management management NN cord-023095-4dannjjm 2124 18 of of IN cord-023095-4dannjjm 2124 19 cats cat NNS cord-023095-4dannjjm 2124 20 with with IN cord-023095-4dannjjm 2124 21 naturally naturally RB cord-023095-4dannjjm 2124 22 occurring occur VBG cord-023095-4dannjjm 2124 23 hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 2124 24 . . . cord-023095-4dannjjm 2125 1 Five five CD cord-023095-4dannjjm 2125 2 domestic domestic JJ cord-023095-4dannjjm 2125 3 shorthair shorthair JJ cord-023095-4dannjjm 2125 4 cats cat NNS cord-023095-4dannjjm 2125 5 ranging range VBG cord-023095-4dannjjm 2125 6 in in IN cord-023095-4dannjjm 2125 7 age age NN cord-023095-4dannjjm 2125 8 from from IN cord-023095-4dannjjm 2125 9 8 8 CD cord-023095-4dannjjm 2125 10 - - SYM cord-023095-4dannjjm 2125 11 17 17 CD cord-023095-4dannjjm 2125 12 years year NNS cord-023095-4dannjjm 2125 13 were be VBD cord-023095-4dannjjm 2125 14 confirmed confirm VBN cord-023095-4dannjjm 2125 15 to to TO cord-023095-4dannjjm 2125 16 have have VB cord-023095-4dannjjm 2125 17 hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 2125 18 based base VBN cord-023095-4dannjjm 2125 19 on on IN cord-023095-4dannjjm 2125 20 persistently persistently RB cord-023095-4dannjjm 2125 21 increased increase VBN cord-023095-4dannjjm 2125 22 serum serum JJ cord-023095-4dannjjm 2125 23 total total JJ cord-023095-4dannjjm 2125 24 thyroxine thyroxine JJ cord-023095-4dannjjm 2125 25 concentrations concentration NNS cord-023095-4dannjjm 2125 26 ( ( -LRB- cord-023095-4dannjjm 2125 27 TT4 TT4 NNP cord-023095-4dannjjm 2125 28 ) ) -RRB- cord-023095-4dannjjm 2125 29 , , , cord-023095-4dannjjm 2125 30 palpable palpable JJ cord-023095-4dannjjm 2125 31 thyroid thyroid NN cord-023095-4dannjjm 2125 32 nodule nodule NN cord-023095-4dannjjm 2125 33 and and CC cord-023095-4dannjjm 2125 34 weight weight NN cord-023095-4dannjjm 2125 35 loss loss NN cord-023095-4dannjjm 2125 36 . . . cord-023095-4dannjjm 2126 1 Serum serum NN cord-023095-4dannjjm 2126 2 TT4 TT4 NNP cord-023095-4dannjjm 2126 3 concentrations concentration NNS cord-023095-4dannjjm 2126 4 ranged range VBD cord-023095-4dannjjm 2126 5 from from IN cord-023095-4dannjjm 2126 6 55 55 CD cord-023095-4dannjjm 2126 7 - - SYM cord-023095-4dannjjm 2126 8 146 146 CD cord-023095-4dannjjm 2126 9 nmol nmol NNP cord-023095-4dannjjm 2126 10 / / SYM cord-023095-4dannjjm 2126 11 l l NN cord-023095-4dannjjm 2126 12 ( ( -LRB- cord-023095-4dannjjm 2126 13 reference reference NN cord-023095-4dannjjm 2126 14 range range NN cord-023095-4dannjjm 2126 15 10 10 CD cord-023095-4dannjjm 2126 16 - - SYM cord-023095-4dannjjm 2126 17 55 55 CD cord-023095-4dannjjm 2126 18 nmol nmol JJ cord-023095-4dannjjm 2126 19 / / SYM cord-023095-4dannjjm 2126 20 l l NN cord-023095-4dannjjm 2126 21 ) ) -RRB- cord-023095-4dannjjm 2126 22 . . . cord-023095-4dannjjm 2127 1 The the DT cord-023095-4dannjjm 2127 2 cats cat NNS cord-023095-4dannjjm 2127 3 were be VBD cord-023095-4dannjjm 2127 4 then then RB cord-023095-4dannjjm 2127 5 fed feed VBN cord-023095-4dannjjm 2127 6 a a DT cord-023095-4dannjjm 2127 7 low low JJ cord-023095-4dannjjm 2127 8 iodine iodine NN cord-023095-4dannjjm 2127 9 containing contain VBG cord-023095-4dannjjm 2127 10 food food NN cord-023095-4dannjjm 2127 11 ( ( -LRB- cord-023095-4dannjjm 2127 12 0.47 0.47 CD cord-023095-4dannjjm 2127 13 ppm ppm NN cord-023095-4dannjjm 2127 14 iodine iodine NN cord-023095-4dannjjm 2127 15 DMB DMB NNP cord-023095-4dannjjm 2127 16 , , , cord-023095-4dannjjm 2127 17 as as IN cord-023095-4dannjjm 2127 18 measured measure VBN cord-023095-4dannjjm 2127 19 by by IN cord-023095-4dannjjm 2127 20 epiboron epiboron NNP cord-023095-4dannjjm 2127 21 neutron neutron NNP cord-023095-4dannjjm 2127 22 atomic atomic NNP cord-023095-4dannjjm 2127 23 activation activation NNP cord-023095-4dannjjm 2127 24 ) ) -RRB- cord-023095-4dannjjm 2127 25 . . . cord-023095-4dannjjm 2128 1 Serum serum NN cord-023095-4dannjjm 2128 2 TT4 TT4 NNP cord-023095-4dannjjm 2128 3 concentrations concentration NNS cord-023095-4dannjjm 2128 4 were be VBD cord-023095-4dannjjm 2128 5 measured measure VBN cord-023095-4dannjjm 2128 6 every every DT cord-023095-4dannjjm 2128 7 3 3 CD cord-023095-4dannjjm 2128 8 weeks week NNS cord-023095-4dannjjm 2128 9 . . . cord-023095-4dannjjm 2129 1 Biochemistry biochemistry NN cord-023095-4dannjjm 2129 2 parameters parameter NNS cord-023095-4dannjjm 2129 3 were be VBD cord-023095-4dannjjm 2129 4 also also RB cord-023095-4dannjjm 2129 5 evaluated evaluate VBN cord-023095-4dannjjm 2129 6 at at IN cord-023095-4dannjjm 2129 7 weeks week NNS cord-023095-4dannjjm 2129 8 0 0 CD cord-023095-4dannjjm 2129 9 , , , cord-023095-4dannjjm 2129 10 6 6 CD cord-023095-4dannjjm 2129 11 and and CC cord-023095-4dannjjm 2129 12 9 9 CD cord-023095-4dannjjm 2129 13 . . . cord-023095-4dannjjm 2130 1 At at IN cord-023095-4dannjjm 2130 2 9 9 CD cord-023095-4dannjjm 2130 3 weeks week NNS cord-023095-4dannjjm 2130 4 , , , cord-023095-4dannjjm 2130 5 serum serum NN cord-023095-4dannjjm 2130 6 TT4 TT4 NNP cord-023095-4dannjjm 2130 7 concentrations concentration NNS cord-023095-4dannjjm 2130 8 had have VBD cord-023095-4dannjjm 2130 9 decreased decrease VBN cord-023095-4dannjjm 2130 10 in in IN cord-023095-4dannjjm 2130 11 all all DT cord-023095-4dannjjm 2130 12 cats cat NNS cord-023095-4dannjjm 2130 13 with with IN cord-023095-4dannjjm 2130 14 4 4 CD cord-023095-4dannjjm 2130 15 of of IN cord-023095-4dannjjm 2130 16 5 5 CD cord-023095-4dannjjm 2130 17 cats cat NNS cord-023095-4dannjjm 2130 18 ( ( -LRB- cord-023095-4dannjjm 2130 19 80 80 CD cord-023095-4dannjjm 2130 20 % % NN cord-023095-4dannjjm 2130 21 ) ) -RRB- cord-023095-4dannjjm 2130 22 being be VBG cord-023095-4dannjjm 2130 23 euthyroid euthyroid NNP cord-023095-4dannjjm 2131 1 ( ( -LRB- cord-023095-4dannjjm 2131 2 mean mean VB cord-023095-4dannjjm 2131 3 48 48 CD cord-023095-4dannjjm 2131 4 nmol nmol JJ cord-023095-4dannjjm 2131 5 / / SYM cord-023095-4dannjjm 2131 6 l l NN cord-023095-4dannjjm 2131 7 ; ; : cord-023095-4dannjjm 2131 8 range range NNP cord-023095-4dannjjm 2131 9 41 41 CD cord-023095-4dannjjm 2131 10 - - SYM cord-023095-4dannjjm 2131 11 54 54 CD cord-023095-4dannjjm 2131 12 nmol nmol JJ cord-023095-4dannjjm 2131 13 / / SYM cord-023095-4dannjjm 2131 14 l l NN cord-023095-4dannjjm 2131 15 ) ) -RRB- cord-023095-4dannjjm 2131 16 . . . cord-023095-4dannjjm 2132 1 The the DT cord-023095-4dannjjm 2132 2 remaining remain VBG cord-023095-4dannjjm 2132 3 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 2132 4 cat cat NN cord-023095-4dannjjm 2132 5 had have VBD cord-023095-4dannjjm 2132 6 an an DT cord-023095-4dannjjm 2132 7 initial initial JJ cord-023095-4dannjjm 2132 8 serum serum NN cord-023095-4dannjjm 2132 9 TT4 tt4 NN cord-023095-4dannjjm 2132 10 of of IN cord-023095-4dannjjm 2132 11 146 146 CD cord-023095-4dannjjm 2132 12 nmol nmol NNP cord-023095-4dannjjm 2132 13 / / SYM cord-023095-4dannjjm 2132 14 l l NN cord-023095-4dannjjm 2132 15 , , , cord-023095-4dannjjm 2132 16 which which WDT cord-023095-4dannjjm 2132 17 decreased decrease VBD cord-023095-4dannjjm 2132 18 to to IN cord-023095-4dannjjm 2132 19 83 83 CD cord-023095-4dannjjm 2132 20 nmol nmol JJ cord-023095-4dannjjm 2132 21 / / SYM cord-023095-4dannjjm 2132 22 l l NN cord-023095-4dannjjm 2132 23 after after IN cord-023095-4dannjjm 2132 24 being be VBG cord-023095-4dannjjm 2132 25 fed feed VBN cord-023095-4dannjjm 2132 26 the the DT cord-023095-4dannjjm 2132 27 iodine iodine NN cord-023095-4dannjjm 2132 28 - - HYPH cord-023095-4dannjjm 2132 29 restricted restrict VBN cord-023095-4dannjjm 2132 30 food food NN cord-023095-4dannjjm 2132 31 . . . cord-023095-4dannjjm 2133 1 Mean mean JJ cord-023095-4dannjjm 2133 2 decrease decrease NN cord-023095-4dannjjm 2133 3 in in IN cord-023095-4dannjjm 2133 4 TT4 TT4 NNP cord-023095-4dannjjm 2133 5 for for IN cord-023095-4dannjjm 2133 6 all all DT cord-023095-4dannjjm 2133 7 5 5 CD cord-023095-4dannjjm 2133 8 cats cat NNS cord-023095-4dannjjm 2133 9 was be VBD cord-023095-4dannjjm 2133 10 26 26 CD cord-023095-4dannjjm 2133 11 nmol nmol JJ cord-023095-4dannjjm 2133 12 / / SYM cord-023095-4dannjjm 2133 13 l l NN cord-023095-4dannjjm 2133 14 ( ( -LRB- cord-023095-4dannjjm 2133 15 range range NNP cord-023095-4dannjjm 2133 16 8 8 CD cord-023095-4dannjjm 2133 17 - - SYM cord-023095-4dannjjm 2133 18 63 63 CD cord-023095-4dannjjm 2133 19 nmol nmol JJ cord-023095-4dannjjm 2133 20 / / SYM cord-023095-4dannjjm 2133 21 l l NN cord-023095-4dannjjm 2133 22 ) ) -RRB- cord-023095-4dannjjm 2133 23 . . . cord-023095-4dannjjm 2134 1 Renal renal JJ cord-023095-4dannjjm 2134 2 parameters parameter NNS cord-023095-4dannjjm 2134 3 remained remain VBD cord-023095-4dannjjm 2134 4 stable stable JJ cord-023095-4dannjjm 2134 5 in in IN cord-023095-4dannjjm 2134 6 all all DT cord-023095-4dannjjm 2134 7 5 5 CD cord-023095-4dannjjm 2134 8 cats cat NNS cord-023095-4dannjjm 2134 9 . . . cord-023095-4dannjjm 2135 1 These these DT cord-023095-4dannjjm 2135 2 5 5 CD cord-023095-4dannjjm 2135 3 cats cat NNS cord-023095-4dannjjm 2135 4 along along IN cord-023095-4dannjjm 2135 5 with with IN cord-023095-4dannjjm 2135 6 4 4 CD cord-023095-4dannjjm 2135 7 additional additional JJ cord-023095-4dannjjm 2135 8 newly newly RB cord-023095-4dannjjm 2135 9 diagnosed diagnose VBN cord-023095-4dannjjm 2135 10 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 2135 11 cats cat NNS cord-023095-4dannjjm 2135 12 were be VBD cord-023095-4dannjjm 2135 13 transitioned transition VBN cord-023095-4dannjjm 2135 14 to to IN cord-023095-4dannjjm 2135 15 a a DT cord-023095-4dannjjm 2135 16 similar similar JJ cord-023095-4dannjjm 2135 17 food food NN cord-023095-4dannjjm 2135 18 that that WDT cord-023095-4dannjjm 2135 19 contained contain VBD cord-023095-4dannjjm 2135 20 less less JJR cord-023095-4dannjjm 2135 21 iodine iodine NN cord-023095-4dannjjm 2135 22 ( ( -LRB- cord-023095-4dannjjm 2135 23 0.28 0.28 CD cord-023095-4dannjjm 2135 24 ppm ppm NN cord-023095-4dannjjm 2135 25 DMB DMB NNP cord-023095-4dannjjm 2135 26 ) ) -RRB- cord-023095-4dannjjm 2135 27 . . . cord-023095-4dannjjm 2136 1 Baseline baseline JJ cord-023095-4dannjjm 2136 2 serum serum NN cord-023095-4dannjjm 2137 1 TT4 TT4 NNP cord-023095-4dannjjm 2137 2 concentrations concentration NNS cord-023095-4dannjjm 2137 3 in in IN cord-023095-4dannjjm 2137 4 the the DT cord-023095-4dannjjm 2137 5 4 4 CD cord-023095-4dannjjm 2137 6 new new JJ cord-023095-4dannjjm 2137 7 cats cat NNS cord-023095-4dannjjm 2137 8 ranged range VBD cord-023095-4dannjjm 2137 9 from from IN cord-023095-4dannjjm 2137 10 55 55 CD cord-023095-4dannjjm 2137 11 - - SYM cord-023095-4dannjjm 2137 12 73 73 CD cord-023095-4dannjjm 2137 13 nmol nmol JJ cord-023095-4dannjjm 2137 14 / / SYM cord-023095-4dannjjm 2137 15 l l NN cord-023095-4dannjjm 2137 16 . . . cord-023095-4dannjjm 2138 1 Serum serum NN cord-023095-4dannjjm 2138 2 TT4 TT4 NNP cord-023095-4dannjjm 2138 3 and and CC cord-023095-4dannjjm 2138 4 other other JJ cord-023095-4dannjjm 2138 5 biochemical biochemical JJ cord-023095-4dannjjm 2138 6 parameters parameter NNS cord-023095-4dannjjm 2138 7 were be VBD cord-023095-4dannjjm 2138 8 monitored monitor VBN cord-023095-4dannjjm 2138 9 every every DT cord-023095-4dannjjm 2138 10 3 3 CD cord-023095-4dannjjm 2138 11 weeks week NNS cord-023095-4dannjjm 2138 12 for for IN cord-023095-4dannjjm 2138 13 9 9 CD cord-023095-4dannjjm 2138 14 weeks week NNS cord-023095-4dannjjm 2138 15 , , , cord-023095-4dannjjm 2138 16 and and CC cord-023095-4dannjjm 2138 17 then then RB cord-023095-4dannjjm 2138 18 every every DT cord-023095-4dannjjm 2138 19 4 4 CD cord-023095-4dannjjm 2138 20 weeks week NNS cord-023095-4dannjjm 2138 21 for for IN cord-023095-4dannjjm 2138 22 an an DT cord-023095-4dannjjm 2138 23 additional additional JJ cord-023095-4dannjjm 2138 24 8 8 CD cord-023095-4dannjjm 2138 25 weeks week NNS cord-023095-4dannjjm 2138 26 . . . cord-023095-4dannjjm 2139 1 With with IN cord-023095-4dannjjm 2139 2 the the DT cord-023095-4dannjjm 2139 3 0.28 0.28 CD cord-023095-4dannjjm 2139 4 ppm ppm NN cord-023095-4dannjjm 2139 5 iodine iodine NN cord-023095-4dannjjm 2139 6 food food NN cord-023095-4dannjjm 2139 7 the the DT cord-023095-4dannjjm 2139 8 four four CD cord-023095-4dannjjm 2139 9 new new JJ cord-023095-4dannjjm 2139 10 cats cat NNS cord-023095-4dannjjm 2139 11 became become VBD cord-023095-4dannjjm 2139 12 euthyroid euthyroid JJ cord-023095-4dannjjm 2139 13 with with IN cord-023095-4dannjjm 2139 14 a a DT cord-023095-4dannjjm 2139 15 mean mean JJ cord-023095-4dannjjm 2139 16 TT4 TT4 NNP cord-023095-4dannjjm 2139 17 concentration concentration NN cord-023095-4dannjjm 2139 18 of of IN cord-023095-4dannjjm 2139 19 41 41 CD cord-023095-4dannjjm 2139 20 nmol/ nmol/ CD cord-023095-4dannjjm 2139 21 ( ( -LRB- cord-023095-4dannjjm 2139 22 range range NN cord-023095-4dannjjm 2139 23 29 29 CD cord-023095-4dannjjm 2139 24 - - HYPH cord-023095-4dannjjm 2139 25 50nmol 50nmol CD cord-023095-4dannjjm 2139 26 / / SYM cord-023095-4dannjjm 2139 27 l l NN cord-023095-4dannjjm 2139 28 ) ) -RRB- cord-023095-4dannjjm 2139 29 . . . cord-023095-4dannjjm 2140 1 The the DT cord-023095-4dannjjm 2140 2 4 4 CD cord-023095-4dannjjm 2140 3 euthyroid euthyroid JJ cord-023095-4dannjjm 2140 4 cats cat NNS cord-023095-4dannjjm 2140 5 from from IN cord-023095-4dannjjm 2140 6 the the DT cord-023095-4dannjjm 2140 7 earlier early JJR cord-023095-4dannjjm 2140 8 feeding feeding NN cord-023095-4dannjjm 2140 9 study study NN cord-023095-4dannjjm 2140 10 had have VBD cord-023095-4dannjjm 2140 11 a a DT cord-023095-4dannjjm 2140 12 further further JJ cord-023095-4dannjjm 2140 13 decrease decrease NN cord-023095-4dannjjm 2140 14 in in IN cord-023095-4dannjjm 2140 15 TT4 TT4 NNP cord-023095-4dannjjm 2140 16 concentration concentration NN cord-023095-4dannjjm 2140 17 ( ( -LRB- cord-023095-4dannjjm 2140 18 mean mean VB cord-023095-4dannjjm 2141 1 TT4 TT4 NNP cord-023095-4dannjjm 2141 2 5 5 CD cord-023095-4dannjjm 2141 3 39 39 CD cord-023095-4dannjjm 2141 4 nmol nmol NNP cord-023095-4dannjjm 2141 5 / / SYM cord-023095-4dannjjm 2141 6 l l NN cord-023095-4dannjjm 2141 7 , , , cord-023095-4dannjjm 2141 8 range range NNP cord-023095-4dannjjm 2141 9 38 38 CD cord-023095-4dannjjm 2141 10 - - HYPH cord-023095-4dannjjm 2141 11 54nmol 54nmol CD cord-023095-4dannjjm 2141 12 / / SYM cord-023095-4dannjjm 2141 13 l l NN cord-023095-4dannjjm 2141 14 ) ) -RRB- cord-023095-4dannjjm 2141 15 . . . cord-023095-4dannjjm 2142 1 The the DT cord-023095-4dannjjm 2142 2 single single JJ cord-023095-4dannjjm 2142 3 non non JJ cord-023095-4dannjjm 2142 4 - - JJ cord-023095-4dannjjm 2142 5 euthyroid euthyroid JJ cord-023095-4dannjjm 2142 6 cat cat NN cord-023095-4dannjjm 2142 7 from from IN cord-023095-4dannjjm 2142 8 the the DT cord-023095-4dannjjm 2142 9 first first JJ cord-023095-4dannjjm 2142 10 study study NN cord-023095-4dannjjm 2142 11 had have VBD cord-023095-4dannjjm 2142 12 a a DT cord-023095-4dannjjm 2142 13 serum serum NN cord-023095-4dannjjm 2142 14 TT4 TT4 NNP cord-023095-4dannjjm 2142 15 concentration concentration NN cord-023095-4dannjjm 2142 16 of of IN cord-023095-4dannjjm 2142 17 61 61 CD cord-023095-4dannjjm 2142 18 nmol nmol JJ cord-023095-4dannjjm 2142 19 / / SYM cord-023095-4dannjjm 2142 20 l l NN cord-023095-4dannjjm 2142 21 , , , cord-023095-4dannjjm 2142 22 a a DT cord-023095-4dannjjm 2142 23 decrease decrease NN cord-023095-4dannjjm 2142 24 from from IN cord-023095-4dannjjm 2142 25 the the DT cord-023095-4dannjjm 2142 26 baseline baseline JJ cord-023095-4dannjjm 2142 27 concentration concentration NN cord-023095-4dannjjm 2142 28 of of IN cord-023095-4dannjjm 2142 29 83 83 CD cord-023095-4dannjjm 2142 30 nmol nmol JJ cord-023095-4dannjjm 2142 31 / / SYM cord-023095-4dannjjm 2142 32 l l NN cord-023095-4dannjjm 2142 33 . . . cord-023095-4dannjjm 2143 1 The the DT cord-023095-4dannjjm 2143 2 average average JJ cord-023095-4dannjjm 2143 3 decrease decrease NN cord-023095-4dannjjm 2143 4 in in IN cord-023095-4dannjjm 2143 5 serum serum NN cord-023095-4dannjjm 2143 6 TT4 TT4 NNP cord-023095-4dannjjm 2143 7 for for IN cord-023095-4dannjjm 2143 8 all all DT cord-023095-4dannjjm 2143 9 9 9 CD cord-023095-4dannjjm 2143 10 cats cat NNS cord-023095-4dannjjm 2143 11 was be VBD cord-023095-4dannjjm 2143 12 20 20 CD cord-023095-4dannjjm 2143 13 nmol nmol JJ cord-023095-4dannjjm 2143 14 / / SYM cord-023095-4dannjjm 2143 15 l l NN cord-023095-4dannjjm 2143 16 ( ( -LRB- cord-023095-4dannjjm 2143 17 range range NNP cord-023095-4dannjjm 2143 18 2 2 CD cord-023095-4dannjjm 2143 19 - - SYM cord-023095-4dannjjm 2143 20 35 35 CD cord-023095-4dannjjm 2143 21 nmol nmol JJ cord-023095-4dannjjm 2143 22 / / SYM cord-023095-4dannjjm 2143 23 l l NN cord-023095-4dannjjm 2143 24 ) ) -RRB- cord-023095-4dannjjm 2143 25 . . . cord-023095-4dannjjm 2144 1 Finally finally RB cord-023095-4dannjjm 2144 2 , , , cord-023095-4dannjjm 2144 3 8 8 CD cord-023095-4dannjjm 2144 4 of of IN cord-023095-4dannjjm 2144 5 the the DT cord-023095-4dannjjm 2144 6 9 9 CD cord-023095-4dannjjm 2144 7 cats cat NNS cord-023095-4dannjjm 2144 8 were be VBD cord-023095-4dannjjm 2144 9 fed feed VBN cord-023095-4dannjjm 2144 10 a a DT cord-023095-4dannjjm 2144 11 third third JJ cord-023095-4dannjjm 2144 12 iodine iodine NN cord-023095-4dannjjm 2144 13 - - HYPH cord-023095-4dannjjm 2144 14 restricted restrict VBN cord-023095-4dannjjm 2144 15 food food NN cord-023095-4dannjjm 2144 16 ( ( -LRB- cord-023095-4dannjjm 2144 17 0.17 0.17 CD cord-023095-4dannjjm 2144 18 ppm ppm NN cord-023095-4dannjjm 2144 19 DMB DMB NNP cord-023095-4dannjjm 2144 20 ) ) -RRB- cord-023095-4dannjjm 2144 21 along along IN cord-023095-4dannjjm 2144 22 with with IN cord-023095-4dannjjm 2144 23 one one CD cord-023095-4dannjjm 2144 24 other other JJ cord-023095-4dannjjm 2144 25 newly newly RB cord-023095-4dannjjm 2144 26 diagnosed diagnose VBN cord-023095-4dannjjm 2144 27 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 2144 28 cat cat NN cord-023095-4dannjjm 2144 29 ( ( -LRB- cord-023095-4dannjjm 2144 30 79 79 CD cord-023095-4dannjjm 2144 31 nmol nmol JJ cord-023095-4dannjjm 2144 32 / / SYM cord-023095-4dannjjm 2144 33 l l NN cord-023095-4dannjjm 2144 34 serum serum NN cord-023095-4dannjjm 2144 35 TT4 TT4 NNP cord-023095-4dannjjm 2144 36 ) ) -RRB- cord-023095-4dannjjm 2144 37 and and CC cord-023095-4dannjjm 2144 38 evaluated evaluate VBD cord-023095-4dannjjm 2144 39 every every DT cord-023095-4dannjjm 2144 40 4 4 CD cord-023095-4dannjjm 2144 41 weeks week NNS cord-023095-4dannjjm 2144 42 . . . cord-023095-4dannjjm 2145 1 All all DT cord-023095-4dannjjm 2145 2 9 9 CD cord-023095-4dannjjm 2145 3 cats cat NNS cord-023095-4dannjjm 2145 4 in in IN cord-023095-4dannjjm 2145 5 this this DT cord-023095-4dannjjm 2145 6 evaluation evaluation NN cord-023095-4dannjjm 2145 7 were be VBD cord-023095-4dannjjm 2145 8 euthyroid euthyroid JJ cord-023095-4dannjjm 2145 9 ( ( -LRB- cord-023095-4dannjjm 2145 10 mean mean VB cord-023095-4dannjjm 2146 1 TT4 TT4 NNP cord-023095-4dannjjm 2146 2 33 33 CD cord-023095-4dannjjm 2146 3 nmol nmol JJ cord-023095-4dannjjm 2146 4 / / SYM cord-023095-4dannjjm 2146 5 l l NN cord-023095-4dannjjm 2146 6 ; ; : cord-023095-4dannjjm 2147 1 range range VBP cord-023095-4dannjjm 2147 2 23 23 CD cord-023095-4dannjjm 2147 3 - - SYM cord-023095-4dannjjm 2147 4 50 50 CD cord-023095-4dannjjm 2147 5 nmol/ nmol/ NNP cord-023095-4dannjjm 2147 6 l l NN cord-023095-4dannjjm 2147 7 ) ) -RRB- cord-023095-4dannjjm 2147 8 . . . cord-023095-4dannjjm 2148 1 This this DT cord-023095-4dannjjm 2148 2 result result NN cord-023095-4dannjjm 2148 3 included include VBD cord-023095-4dannjjm 2148 4 the the DT cord-023095-4dannjjm 2148 5 cat cat NN cord-023095-4dannjjm 2148 6 whose whose WP$ cord-023095-4dannjjm 2148 7 serum serum NN cord-023095-4dannjjm 2148 8 TT4 TT4 NNP cord-023095-4dannjjm 2148 9 remained remain VBD cord-023095-4dannjjm 2148 10 in in IN cord-023095-4dannjjm 2148 11 the the DT cord-023095-4dannjjm 2148 12 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 2148 13 range range NN cord-023095-4dannjjm 2148 14 in in IN cord-023095-4dannjjm 2148 15 the the DT cord-023095-4dannjjm 2148 16 first first JJ cord-023095-4dannjjm 2148 17 two two CD cord-023095-4dannjjm 2148 18 evaluations evaluation NNS cord-023095-4dannjjm 2148 19 . . . cord-023095-4dannjjm 2149 1 The the DT cord-023095-4dannjjm 2149 2 average average JJ cord-023095-4dannjjm 2149 3 decrease decrease NN cord-023095-4dannjjm 2149 4 in in IN cord-023095-4dannjjm 2149 5 TT4 TT4 NNP cord-023095-4dannjjm 2149 6 was be VBD cord-023095-4dannjjm 2149 7 13 13 CD cord-023095-4dannjjm 2149 8 nmol nmol JJ cord-023095-4dannjjm 2149 9 / / SYM cord-023095-4dannjjm 2149 10 l l NN cord-023095-4dannjjm 2149 11 ( ( -LRB- cord-023095-4dannjjm 2149 12 range range NNP cord-023095-4dannjjm 2149 13 0 0 CD cord-023095-4dannjjm 2149 14 - - SYM cord-023095-4dannjjm 2149 15 43 43 CD cord-023095-4dannjjm 2149 16 nmol nmol JJ cord-023095-4dannjjm 2149 17 / / SYM cord-023095-4dannjjm 2149 18 l l NN cord-023095-4dannjjm 2149 19 ) ) -RRB- cord-023095-4dannjjm 2149 20 . . . cord-023095-4dannjjm 2150 1 Biochemical biochemical JJ cord-023095-4dannjjm 2150 2 features feature NNS cord-023095-4dannjjm 2150 3 of of IN cord-023095-4dannjjm 2150 4 renal renal JJ cord-023095-4dannjjm 2150 5 function function NN cord-023095-4dannjjm 2150 6 remained remain VBD cord-023095-4dannjjm 2150 7 stable stable JJ cord-023095-4dannjjm 2150 8 and and CC cord-023095-4dannjjm 2150 9 no no DT cord-023095-4dannjjm 2150 10 other other JJ cord-023095-4dannjjm 2150 11 biochemical biochemical JJ cord-023095-4dannjjm 2150 12 abnormalities abnormality NNS cord-023095-4dannjjm 2150 13 were be VBD cord-023095-4dannjjm 2150 14 observed observe VBN cord-023095-4dannjjm 2150 15 . . . cord-023095-4dannjjm 2151 1 In in IN cord-023095-4dannjjm 2151 2 summary summary NN cord-023095-4dannjjm 2151 3 , , , cord-023095-4dannjjm 2151 4 the the DT cord-023095-4dannjjm 2151 5 results result NNS cord-023095-4dannjjm 2151 6 of of IN cord-023095-4dannjjm 2151 7 these these DT cord-023095-4dannjjm 2151 8 three three CD cord-023095-4dannjjm 2151 9 feeding feeding NN cord-023095-4dannjjm 2151 10 studies study NNS cord-023095-4dannjjm 2151 11 demonstrate demonstrate VBP cord-023095-4dannjjm 2151 12 that that IN cord-023095-4dannjjm 2151 13 feline feline JJ cord-023095-4dannjjm 2151 14 hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 2151 15 can can MD cord-023095-4dannjjm 2151 16 be be VB cord-023095-4dannjjm 2151 17 managed manage VBN cord-023095-4dannjjm 2151 18 effectively effectively RB cord-023095-4dannjjm 2151 19 with with IN cord-023095-4dannjjm 2151 20 dietary dietary JJ cord-023095-4dannjjm 2151 21 iodine iodine NN cord-023095-4dannjjm 2151 22 restriction restriction NN cord-023095-4dannjjm 2151 23 . . . cord-023095-4dannjjm 2152 1 We -PRON- PRP cord-023095-4dannjjm 2152 2 have have VBP cord-023095-4dannjjm 2152 3 shown show VBN cord-023095-4dannjjm 2152 4 previously previously RB cord-023095-4dannjjm 2152 5 that that DT cord-023095-4dannjjm 2152 6 restriction restriction NN cord-023095-4dannjjm 2152 7 of of IN cord-023095-4dannjjm 2152 8 dietary dietary JJ cord-023095-4dannjjm 2152 9 iodine iodine NN cord-023095-4dannjjm 2152 10 ( ( -LRB- cord-023095-4dannjjm 2152 11 I i NN cord-023095-4dannjjm 2152 12 ) ) -RRB- cord-023095-4dannjjm 2152 13 is be VBZ cord-023095-4dannjjm 2152 14 a a DT cord-023095-4dannjjm 2152 15 safe safe JJ cord-023095-4dannjjm 2152 16 and and CC cord-023095-4dannjjm 2152 17 effective effective JJ cord-023095-4dannjjm 2152 18 method method NN cord-023095-4dannjjm 2152 19 for for IN cord-023095-4dannjjm 2152 20 decreasing decrease VBG cord-023095-4dannjjm 2152 21 serum serum NN cord-023095-4dannjjm 2152 22 thyroxine thyroxine JJ cord-023095-4dannjjm 2152 23 concentrations concentration NNS cord-023095-4dannjjm 2152 24 ( ( -LRB- cord-023095-4dannjjm 2152 25 TT4 TT4 NNP cord-023095-4dannjjm 2152 26 ) ) -RRB- cord-023095-4dannjjm 2152 27 in in IN cord-023095-4dannjjm 2152 28 cats cat NNS cord-023095-4dannjjm 2152 29 with with IN cord-023095-4dannjjm 2152 30 hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 2152 31 . . . cord-023095-4dannjjm 2153 1 The the DT cord-023095-4dannjjm 2153 2 objective objective NN cord-023095-4dannjjm 2153 3 of of IN cord-023095-4dannjjm 2153 4 this this DT cord-023095-4dannjjm 2153 5 study study NN cord-023095-4dannjjm 2153 6 was be VBD cord-023095-4dannjjm 2153 7 to to TO cord-023095-4dannjjm 2153 8 determine determine VB cord-023095-4dannjjm 2153 9 the the DT cord-023095-4dannjjm 2153 10 maximum maximum JJ cord-023095-4dannjjm 2153 11 level level NN cord-023095-4dannjjm 2153 12 of of IN cord-023095-4dannjjm 2153 13 iodine iodine NN cord-023095-4dannjjm 2153 14 in in IN cord-023095-4dannjjm 2153 15 a a DT cord-023095-4dannjjm 2153 16 nutritionally nutritionally RB cord-023095-4dannjjm 2153 17 balanced balanced JJ cord-023095-4dannjjm 2153 18 feline feline JJ cord-023095-4dannjjm 2153 19 mature mature JJ cord-023095-4dannjjm 2153 20 adult adult NN cord-023095-4dannjjm 2153 21 food food NN cord-023095-4dannjjm 2153 22 required require VBN cord-023095-4dannjjm 2153 23 to to TO cord-023095-4dannjjm 2153 24 maintain maintain VB cord-023095-4dannjjm 2153 25 normal normal JJ cord-023095-4dannjjm 2153 26 serum serum NN cord-023095-4dannjjm 2153 27 TT4 TT4 NNP cord-023095-4dannjjm 2153 28 concentrations concentration NNS cord-023095-4dannjjm 2153 29 in in IN cord-023095-4dannjjm 2153 30 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 2153 31 cats cat NNS cord-023095-4dannjjm 2153 32 currently currently RB cord-023095-4dannjjm 2153 33 being be VBG cord-023095-4dannjjm 2153 34 controlled control VBN cord-023095-4dannjjm 2153 35 on on IN cord-023095-4dannjjm 2153 36 a a DT cord-023095-4dannjjm 2153 37 food food NN cord-023095-4dannjjm 2153 38 containing contain VBG cord-023095-4dannjjm 2153 39 0.15 0.15 CD cord-023095-4dannjjm 2153 40 ppm ppm NN cord-023095-4dannjjm 2154 1 I -PRON- PRP cord-023095-4dannjjm 2154 2 ( ( -LRB- cord-023095-4dannjjm 2154 3 DMB DMB NNP cord-023095-4dannjjm 2154 4 ) ) -RRB- cord-023095-4dannjjm 2154 5 as as IN cord-023095-4dannjjm 2154 6 measured measure VBN cord-023095-4dannjjm 2154 7 by by IN cord-023095-4dannjjm 2154 8 epiboron epiboron NNP cord-023095-4dannjjm 2154 9 neutron neutron NNP cord-023095-4dannjjm 2154 10 atomic atomic NNP cord-023095-4dannjjm 2154 11 activation activation NN cord-023095-4dannjjm 2154 12 . . . cord-023095-4dannjjm 2155 1 All all DT cord-023095-4dannjjm 2155 2 cats cat NNS cord-023095-4dannjjm 2155 3 were be VBD cord-023095-4dannjjm 2155 4 previously previously RB cord-023095-4dannjjm 2155 5 diagnosed diagnose VBN cord-023095-4dannjjm 2155 6 at at IN cord-023095-4dannjjm 2155 7 least least RBS cord-023095-4dannjjm 2155 8 14 14 CD cord-023095-4dannjjm 2155 9 months month NNS cord-023095-4dannjjm 2155 10 prior prior RB cord-023095-4dannjjm 2155 11 to to IN cord-023095-4dannjjm 2155 12 the the DT cord-023095-4dannjjm 2155 13 start start NN cord-023095-4dannjjm 2155 14 of of IN cord-023095-4dannjjm 2155 15 the the DT cord-023095-4dannjjm 2155 16 study study NN cord-023095-4dannjjm 2155 17 and and CC cord-023095-4dannjjm 2155 18 their -PRON- PRP$ cord-023095-4dannjjm 2155 19 TT4 TT4 NNP cord-023095-4dannjjm 2155 20 concentrations concentration NNS cord-023095-4dannjjm 2155 21 were be VBD cord-023095-4dannjjm 2155 22 maintained maintain VBN cord-023095-4dannjjm 2155 23 in in IN cord-023095-4dannjjm 2155 24 the the DT cord-023095-4dannjjm 2155 25 normal normal JJ cord-023095-4dannjjm 2155 26 range range NN cord-023095-4dannjjm 2155 27 by by IN cord-023095-4dannjjm 2155 28 dietary dietary JJ cord-023095-4dannjjm 2155 29 iodine iodine NN cord-023095-4dannjjm 2155 30 restriction restriction NN cord-023095-4dannjjm 2155 31 for for IN cord-023095-4dannjjm 2155 32 a a DT cord-023095-4dannjjm 2155 33 minimum minimum NN cord-023095-4dannjjm 2155 34 of of IN cord-023095-4dannjjm 2155 35 10 10 CD cord-023095-4dannjjm 2155 36 months month NNS cord-023095-4dannjjm 2155 37 ( ( -LRB- cord-023095-4dannjjm 2155 38 range range VBP cord-023095-4dannjjm 2155 39 10 10 CD cord-023095-4dannjjm 2155 40 months-3 months-3 JJ cord-023095-4dannjjm 2155 41 years year NNS cord-023095-4dannjjm 2155 42 ) ) -RRB- cord-023095-4dannjjm 2155 43 . . . cord-023095-4dannjjm 2156 1 Serum serum NN cord-023095-4dannjjm 2156 2 TT4 TT4 NNP cord-023095-4dannjjm 2156 3 concentrations concentration NNS cord-023095-4dannjjm 2156 4 ranged range VBD cord-023095-4dannjjm 2156 5 from from IN cord-023095-4dannjjm 2156 6 9 9 CD cord-023095-4dannjjm 2156 7 - - SYM cord-023095-4dannjjm 2156 8 42 42 CD cord-023095-4dannjjm 2156 9 nmol nmol JJ cord-023095-4dannjjm 2156 10 / / SYM cord-023095-4dannjjm 2156 11 l l NN cord-023095-4dannjjm 2156 12 ( ( -LRB- cord-023095-4dannjjm 2156 13 reference reference NN cord-023095-4dannjjm 2156 14 range range NN cord-023095-4dannjjm 2156 15 10 10 CD cord-023095-4dannjjm 2156 16 - - SYM cord-023095-4dannjjm 2156 17 55 55 CD cord-023095-4dannjjm 2156 18 nmol nmol JJ cord-023095-4dannjjm 2156 19 / / SYM cord-023095-4dannjjm 2156 20 l l NN cord-023095-4dannjjm 2156 21 ) ) -RRB- cord-023095-4dannjjm 2156 22 at at IN cord-023095-4dannjjm 2156 23 the the DT cord-023095-4dannjjm 2156 24 beginning beginning NN cord-023095-4dannjjm 2156 25 of of IN cord-023095-4dannjjm 2156 26 the the DT cord-023095-4dannjjm 2156 27 study study NN cord-023095-4dannjjm 2156 28 . . . cord-023095-4dannjjm 2157 1 The the DT cord-023095-4dannjjm 2157 2 cats cat NNS cord-023095-4dannjjm 2157 3 were be VBD cord-023095-4dannjjm 2157 4 divided divide VBN cord-023095-4dannjjm 2157 5 into into IN cord-023095-4dannjjm 2157 6 two two CD cord-023095-4dannjjm 2157 7 groups group NNS cord-023095-4dannjjm 2157 8 each each DT cord-023095-4dannjjm 2157 9 containing contain VBG cord-023095-4dannjjm 2157 10 9 9 CD cord-023095-4dannjjm 2157 11 cats cat NNS cord-023095-4dannjjm 2157 12 . . . cord-023095-4dannjjm 2158 1 Groups group NNS cord-023095-4dannjjm 2158 2 were be VBD cord-023095-4dannjjm 2158 3 similar similar JJ cord-023095-4dannjjm 2158 4 in in IN cord-023095-4dannjjm 2158 5 age age NN cord-023095-4dannjjm 2158 6 and and CC cord-023095-4dannjjm 2158 7 gender gender NN cord-023095-4dannjjm 2158 8 distribution distribution NN cord-023095-4dannjjm 2159 1 ( ( -LRB- cord-023095-4dannjjm 2159 2 mean mean UH cord-023095-4dannjjm 2159 3 age age NN cord-023095-4dannjjm 2159 4 5 5 CD cord-023095-4dannjjm 2159 5 13.8 13.8 CD cord-023095-4dannjjm 2159 6 years year NNS cord-023095-4dannjjm 2159 7 , , , cord-023095-4dannjjm 2159 8 range range VBP cord-023095-4dannjjm 2159 9 12 12 CD cord-023095-4dannjjm 2159 10 - - SYM cord-023095-4dannjjm 2159 11 18 18 CD cord-023095-4dannjjm 2159 12 years year NNS cord-023095-4dannjjm 2159 13 ) ) -RRB- cord-023095-4dannjjm 2159 14 . . . cord-023095-4dannjjm 2160 1 One one CD cord-023095-4dannjjm 2160 2 group group NN cord-023095-4dannjjm 2160 3 ( ( -LRB- cord-023095-4dannjjm 2160 4 Group Group NNP cord-023095-4dannjjm 2160 5 A A NNP cord-023095-4dannjjm 2160 6 ) ) -RRB- cord-023095-4dannjjm 2160 7 was be VBD cord-023095-4dannjjm 2160 8 placed place VBN cord-023095-4dannjjm 2160 9 on on IN cord-023095-4dannjjm 2160 10 a a DT cord-023095-4dannjjm 2160 11 food food NN cord-023095-4dannjjm 2160 12 that that WDT cord-023095-4dannjjm 2160 13 was be VBD cord-023095-4dannjjm 2160 14 formulated formulate VBN cord-023095-4dannjjm 2160 15 for for IN cord-023095-4dannjjm 2160 16 mature mature JJ cord-023095-4dannjjm 2160 17 adult adult NN cord-023095-4dannjjm 2160 18 cats cat NNS cord-023095-4dannjjm 2160 19 containing contain VBG cord-023095-4dannjjm 2160 20 0.39 0.39 CD cord-023095-4dannjjm 2160 21 ppm ppm NN cord-023095-4dannjjm 2160 22 I i NN cord-023095-4dannjjm 2160 23 ( ( -LRB- cord-023095-4dannjjm 2160 24 DMB DMB NNP cord-023095-4dannjjm 2160 25 ) ) -RRB- cord-023095-4dannjjm 2160 26 . . . cord-023095-4dannjjm 2161 1 The the DT cord-023095-4dannjjm 2161 2 other other JJ cord-023095-4dannjjm 2161 3 group group NN cord-023095-4dannjjm 2161 4 ( ( -LRB- cord-023095-4dannjjm 2161 5 Group Group NNP cord-023095-4dannjjm 2161 6 B B NNP cord-023095-4dannjjm 2161 7 ) ) -RRB- cord-023095-4dannjjm 2161 8 was be VBD cord-023095-4dannjjm 2161 9 placed place VBN cord-023095-4dannjjm 2161 10 on on IN cord-023095-4dannjjm 2161 11 a a DT cord-023095-4dannjjm 2161 12 similar similar JJ cord-023095-4dannjjm 2161 13 food food NN cord-023095-4dannjjm 2161 14 that that WDT cord-023095-4dannjjm 2161 15 differed differ VBD cord-023095-4dannjjm 2161 16 only only RB cord-023095-4dannjjm 2161 17 in in IN cord-023095-4dannjjm 2161 18 that that IN cord-023095-4dannjjm 2161 19 it -PRON- PRP cord-023095-4dannjjm 2161 20 contained contain VBD cord-023095-4dannjjm 2162 1 0.47 0.47 CD cord-023095-4dannjjm 2162 2 ppm ppm NN cord-023095-4dannjjm 2163 1 I -PRON- PRP cord-023095-4dannjjm 2163 2 ( ( -LRB- cord-023095-4dannjjm 2163 3 DMB DMB NNP cord-023095-4dannjjm 2163 4 ) ) -RRB- cord-023095-4dannjjm 2163 5 . . . cord-023095-4dannjjm 2164 1 Blood blood NN cord-023095-4dannjjm 2164 2 was be VBD cord-023095-4dannjjm 2164 3 collected collect VBN cord-023095-4dannjjm 2164 4 from from IN cord-023095-4dannjjm 2164 5 all all DT cord-023095-4dannjjm 2164 6 cats cat NNS cord-023095-4dannjjm 2164 7 every every DT cord-023095-4dannjjm 2164 8 three three CD cord-023095-4dannjjm 2164 9 weeks week NNS cord-023095-4dannjjm 2164 10 and and CC cord-023095-4dannjjm 2164 11 analyzed analyze VBD cord-023095-4dannjjm 2164 12 for for IN cord-023095-4dannjjm 2164 13 serum serum NN cord-023095-4dannjjm 2164 14 TT4 TT4 NNP cord-023095-4dannjjm 2164 15 concentration concentration NN cord-023095-4dannjjm 2164 16 . . . cord-023095-4dannjjm 2165 1 Biochemistry biochemistry NN cord-023095-4dannjjm 2165 2 parameters parameter NNS cord-023095-4dannjjm 2165 3 were be VBD cord-023095-4dannjjm 2165 4 also also RB cord-023095-4dannjjm 2165 5 evaluated evaluate VBN cord-023095-4dannjjm 2165 6 at at IN cord-023095-4dannjjm 2165 7 weeks week NNS cord-023095-4dannjjm 2165 8 0 0 CD cord-023095-4dannjjm 2165 9 , , , cord-023095-4dannjjm 2165 10 6 6 CD cord-023095-4dannjjm 2165 11 and and CC cord-023095-4dannjjm 2165 12 9 9 CD cord-023095-4dannjjm 2165 13 . . . cord-023095-4dannjjm 2166 1 All all DT cord-023095-4dannjjm 2166 2 Group Group NNP cord-023095-4dannjjm 2166 3 A a DT cord-023095-4dannjjm 2166 4 cats cat NNS cord-023095-4dannjjm 2166 5 exhibited exhibit VBD cord-023095-4dannjjm 2166 6 increases increase NNS cord-023095-4dannjjm 2166 7 in in IN cord-023095-4dannjjm 2166 8 serum serum NN cord-023095-4dannjjm 2166 9 TT4 TT4 NNP cord-023095-4dannjjm 2166 10 concentration concentration NN cord-023095-4dannjjm 2166 11 ( ( -LRB- cord-023095-4dannjjm 2166 12 mean mean JJ cord-023095-4dannjjm 2166 13 increase increase NN cord-023095-4dannjjm 2166 14 of of IN cord-023095-4dannjjm 2166 15 25 25 CD cord-023095-4dannjjm 2166 16 nmol nmol JJ cord-023095-4dannjjm 2166 17 / / SYM cord-023095-4dannjjm 2166 18 l l NN cord-023095-4dannjjm 2166 19 above above IN cord-023095-4dannjjm 2166 20 baseline baseline NN cord-023095-4dannjjm 2166 21 , , , cord-023095-4dannjjm 2166 22 range range VBP cord-023095-4dannjjm 2166 23 5 5 CD cord-023095-4dannjjm 2166 24 - - SYM cord-023095-4dannjjm 2166 25 48 48 CD cord-023095-4dannjjm 2166 26 nmol nmol JJ cord-023095-4dannjjm 2166 27 / / SYM cord-023095-4dannjjm 2166 28 l l NN cord-023095-4dannjjm 2166 29 ) ) -RRB- cord-023095-4dannjjm 2166 30 . . . cord-023095-4dannjjm 2167 1 Seven seven CD cord-023095-4dannjjm 2167 2 of of IN cord-023095-4dannjjm 2167 3 the the DT cord-023095-4dannjjm 2167 4 cats cat NNS cord-023095-4dannjjm 2167 5 remained remain VBD cord-023095-4dannjjm 2167 6 in in IN cord-023095-4dannjjm 2167 7 the the DT cord-023095-4dannjjm 2167 8 euthyroid euthyroid JJ cord-023095-4dannjjm 2167 9 range range NN cord-023095-4dannjjm 2167 10 ( ( -LRB- cord-023095-4dannjjm 2167 11 mean mean VB cord-023095-4dannjjm 2167 12 serum serum NN cord-023095-4dannjjm 2167 13 TT4 TT4 NNP cord-023095-4dannjjm 2167 14 5 5 CD cord-023095-4dannjjm 2167 15 36 36 CD cord-023095-4dannjjm 2167 16 nmol nmol JJ cord-023095-4dannjjm 2167 17 / / SYM cord-023095-4dannjjm 2167 18 l l NN cord-023095-4dannjjm 2167 19 , , , cord-023095-4dannjjm 2167 20 range-27 range-27 NNP cord-023095-4dannjjm 2167 21 - - SYM cord-023095-4dannjjm 2167 22 54 54 CD cord-023095-4dannjjm 2167 23 nmol nmol JJ cord-023095-4dannjjm 2167 24 / / SYM cord-023095-4dannjjm 2167 25 l l NN cord-023095-4dannjjm 2167 26 ) ) -RRB- cord-023095-4dannjjm 2167 27 . . . cord-023095-4dannjjm 2168 1 Two two CD cord-023095-4dannjjm 2168 2 cats cat NNS cord-023095-4dannjjm 2168 3 exceeded exceed VBD cord-023095-4dannjjm 2168 4 the the DT cord-023095-4dannjjm 2168 5 upper upper JJ cord-023095-4dannjjm 2168 6 limit limit NN cord-023095-4dannjjm 2168 7 of of IN cord-023095-4dannjjm 2168 8 the the DT cord-023095-4dannjjm 2168 9 reference reference NN cord-023095-4dannjjm 2168 10 range range NN cord-023095-4dannjjm 2168 11 ( ( -LRB- cord-023095-4dannjjm 2168 12 59 59 CD cord-023095-4dannjjm 2168 13 and and CC cord-023095-4dannjjm 2168 14 76 76 CD cord-023095-4dannjjm 2168 15 nmol nmol NN cord-023095-4dannjjm 2168 16 / / SYM cord-023095-4dannjjm 2168 17 l l NN cord-023095-4dannjjm 2168 18 respectively respectively RB cord-023095-4dannjjm 2168 19 ) ) -RRB- cord-023095-4dannjjm 2168 20 . . . cord-023095-4dannjjm 2169 1 The the DT cord-023095-4dannjjm 2169 2 cats cat NNS cord-023095-4dannjjm 2169 3 in in IN cord-023095-4dannjjm 2169 4 Group Group NNP cord-023095-4dannjjm 2169 5 B B NNP cord-023095-4dannjjm 2169 6 also also RB cord-023095-4dannjjm 2169 7 exhibited exhibit VBD cord-023095-4dannjjm 2169 8 increases increase NNS cord-023095-4dannjjm 2169 9 in in IN cord-023095-4dannjjm 2169 10 serum serum NN cord-023095-4dannjjm 2169 11 TT4 TT4 NNP cord-023095-4dannjjm 2169 12 concentration concentration NN cord-023095-4dannjjm 2169 13 but but CC cord-023095-4dannjjm 2169 14 to to IN cord-023095-4dannjjm 2169 15 a a DT cord-023095-4dannjjm 2169 16 greater great JJR cord-023095-4dannjjm 2169 17 degree degree NN cord-023095-4dannjjm 2169 18 than than IN cord-023095-4dannjjm 2169 19 the the DT cord-023095-4dannjjm 2169 20 cats cat NNS cord-023095-4dannjjm 2169 21 in in IN cord-023095-4dannjjm 2169 22 Group Group NNP cord-023095-4dannjjm 2169 23 A A NNP cord-023095-4dannjjm 2169 24 ( ( -LRB- cord-023095-4dannjjm 2169 25 mean mean UH cord-023095-4dannjjm 2169 26 increase increase NN cord-023095-4dannjjm 2169 27 39 39 CD cord-023095-4dannjjm 2169 28 nmol nmol JJ cord-023095-4dannjjm 2169 29 / / SYM cord-023095-4dannjjm 2169 30 l l NN cord-023095-4dannjjm 2169 31 , , , cord-023095-4dannjjm 2169 32 range range NNP cord-023095-4dannjjm 2169 33 20 20 CD cord-023095-4dannjjm 2169 34 - - SYM cord-023095-4dannjjm 2169 35 60nmol 60nmol NN cord-023095-4dannjjm 2169 36 / / SYM cord-023095-4dannjjm 2169 37 l l NN cord-023095-4dannjjm 2169 38 ) ) -RRB- cord-023095-4dannjjm 2169 39 . . . cord-023095-4dannjjm 2170 1 Four four CD cord-023095-4dannjjm 2170 2 cats cat NNS cord-023095-4dannjjm 2170 3 remained remain VBD cord-023095-4dannjjm 2170 4 in in IN cord-023095-4dannjjm 2170 5 the the DT cord-023095-4dannjjm 2170 6 euthyroid euthyroid JJ cord-023095-4dannjjm 2170 7 range range NN cord-023095-4dannjjm 2170 8 ( ( -LRB- cord-023095-4dannjjm 2170 9 mean mean VB cord-023095-4dannjjm 2171 1 serum serum NNP cord-023095-4dannjjm 2171 2 TT4 TT4 NNP cord-023095-4dannjjm 2171 3 5 5 CD cord-023095-4dannjjm 2171 4 41 41 CD cord-023095-4dannjjm 2171 5 , , , cord-023095-4dannjjm 2171 6 range range VBP cord-023095-4dannjjm 2171 7 29 29 CD cord-023095-4dannjjm 2171 8 - - SYM cord-023095-4dannjjm 2171 9 49 49 CD cord-023095-4dannjjm 2171 10 nmol nmol JJ cord-023095-4dannjjm 2171 11 / / SYM cord-023095-4dannjjm 2171 12 l l NN cord-023095-4dannjjm 2171 13 ) ) -RRB- cord-023095-4dannjjm 2171 14 . . . cord-023095-4dannjjm 2172 1 The the DT cord-023095-4dannjjm 2172 2 five five CD cord-023095-4dannjjm 2172 3 remaining remain VBG cord-023095-4dannjjm 2172 4 cats cat NNS cord-023095-4dannjjm 2172 5 all all DT cord-023095-4dannjjm 2172 6 exceeded exceed VBD cord-023095-4dannjjm 2172 7 the the DT cord-023095-4dannjjm 2172 8 upper upper JJ cord-023095-4dannjjm 2172 9 limit limit NN cord-023095-4dannjjm 2172 10 of of IN cord-023095-4dannjjm 2172 11 the the DT cord-023095-4dannjjm 2172 12 reference reference NN cord-023095-4dannjjm 2172 13 range range NN cord-023095-4dannjjm 2172 14 ( ( -LRB- cord-023095-4dannjjm 2172 15 mean mean VB cord-023095-4dannjjm 2172 16 serum serum NN cord-023095-4dannjjm 2172 17 TT4 TT4 NNP cord-023095-4dannjjm 2172 18 5 5 CD cord-023095-4dannjjm 2172 19 76 76 CD cord-023095-4dannjjm 2172 20 nmol nmol NN cord-023095-4dannjjm 2172 21 / / SYM cord-023095-4dannjjm 2172 22 l l NN cord-023095-4dannjjm 2172 23 , , , cord-023095-4dannjjm 2172 24 range-59 range-59 NNP cord-023095-4dannjjm 2172 25 - - HYPH cord-023095-4dannjjm 2172 26 99 99 CD cord-023095-4dannjjm 2172 27 nmol nmol JJ cord-023095-4dannjjm 2172 28 / / SYM cord-023095-4dannjjm 2172 29 l l NN cord-023095-4dannjjm 2172 30 ) ) -RRB- cord-023095-4dannjjm 2172 31 . . . cord-023095-4dannjjm 2173 1 All all DT cord-023095-4dannjjm 2173 2 cats cat NNS cord-023095-4dannjjm 2173 3 returned return VBD cord-023095-4dannjjm 2173 4 to to IN cord-023095-4dannjjm 2173 5 a a DT cord-023095-4dannjjm 2173 6 euthyroid euthyroid JJ cord-023095-4dannjjm 2173 7 state state NN cord-023095-4dannjjm 2173 8 within within IN cord-023095-4dannjjm 2173 9 1 1 CD cord-023095-4dannjjm 2173 10 month month NN cord-023095-4dannjjm 2173 11 of of IN cord-023095-4dannjjm 2173 12 being be VBG cord-023095-4dannjjm 2173 13 returned return VBN cord-023095-4dannjjm 2173 14 to to IN cord-023095-4dannjjm 2173 15 a a DT cord-023095-4dannjjm 2173 16 diet diet NN cord-023095-4dannjjm 2173 17 containing contain VBG cord-023095-4dannjjm 2173 18 0.17 0.17 CD cord-023095-4dannjjm 2173 19 ppm ppm NN cord-023095-4dannjjm 2173 20 I i NN cord-023095-4dannjjm 2173 21 ( ( -LRB- cord-023095-4dannjjm 2173 22 DMB DMB NNP cord-023095-4dannjjm 2173 23 ) ) -RRB- cord-023095-4dannjjm 2173 24 . . . cord-023095-4dannjjm 2174 1 It -PRON- PRP cord-023095-4dannjjm 2174 2 was be VBD cord-023095-4dannjjm 2174 3 determined determine VBN cord-023095-4dannjjm 2174 4 that that IN cord-023095-4dannjjm 2174 5 serum serum NN cord-023095-4dannjjm 2174 6 TT4 TT4 NNP cord-023095-4dannjjm 2174 7 concentrations concentration NNS cord-023095-4dannjjm 2174 8 are be VBP cord-023095-4dannjjm 2174 9 not not RB cord-023095-4dannjjm 2174 10 ideally ideally RB cord-023095-4dannjjm 2174 11 controlled control VBN cord-023095-4dannjjm 2174 12 in in IN cord-023095-4dannjjm 2174 13 the the DT cord-023095-4dannjjm 2174 14 normal normal JJ cord-023095-4dannjjm 2174 15 range range NN cord-023095-4dannjjm 2174 16 in in IN cord-023095-4dannjjm 2174 17 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 2174 18 cats cat NNS cord-023095-4dannjjm 2174 19 fed feed VBD cord-023095-4dannjjm 2174 20 a a DT cord-023095-4dannjjm 2174 21 food food NN cord-023095-4dannjjm 2174 22 containing contain VBG cord-023095-4dannjjm 2174 23 ! ! . cord-023095-4dannjjm 2175 1 0.39 0.39 CD cord-023095-4dannjjm 2176 1 ppm ppm NN cord-023095-4dannjjm 2176 2 I I NNP cord-023095-4dannjjm 2176 3 ( ( -LRB- cord-023095-4dannjjm 2176 4 DMB DMB NNP cord-023095-4dannjjm 2176 5 ) ) -RRB- cord-023095-4dannjjm 2176 6 . . . cord-023095-4dannjjm 2177 1 Hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 2177 2 is be VBZ cord-023095-4dannjjm 2177 3 a a DT cord-023095-4dannjjm 2177 4 common common JJ cord-023095-4dannjjm 2177 5 disease disease NN cord-023095-4dannjjm 2177 6 in in IN cord-023095-4dannjjm 2177 7 old old JJ cord-023095-4dannjjm 2177 8 cats cat NNS cord-023095-4dannjjm 2177 9 . . . cord-023095-4dannjjm 2178 1 Excessive excessive JJ cord-023095-4dannjjm 2178 2 production production NN cord-023095-4dannjjm 2178 3 of of IN cord-023095-4dannjjm 2178 4 thyroid thyroid JJ cord-023095-4dannjjm 2178 5 hormones hormone NNS cord-023095-4dannjjm 2178 6 is be VBZ cord-023095-4dannjjm 2178 7 the the DT cord-023095-4dannjjm 2178 8 hallmark hallmark NN cord-023095-4dannjjm 2178 9 of of IN cord-023095-4dannjjm 2178 10 the the DT cord-023095-4dannjjm 2178 11 disease disease NN cord-023095-4dannjjm 2178 12 . . . cord-023095-4dannjjm 2179 1 Three three CD cord-023095-4dannjjm 2179 2 main main JJ cord-023095-4dannjjm 2179 3 treatments treatment NNS cord-023095-4dannjjm 2179 4 for for IN cord-023095-4dannjjm 2179 5 feline feline JJ cord-023095-4dannjjm 2179 6 hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 2179 7 include include VBP cord-023095-4dannjjm 2179 8 radioactive radioactive JJ cord-023095-4dannjjm 2179 9 iodine iodine NN cord-023095-4dannjjm 2179 10 , , , cord-023095-4dannjjm 2179 11 thyroidectomy thyroidectomy NN cord-023095-4dannjjm 2179 12 , , , cord-023095-4dannjjm 2179 13 and and CC cord-023095-4dannjjm 2179 14 antithyroid antithyroid NNP cord-023095-4dannjjm 2179 15 drugs drug NNS cord-023095-4dannjjm 2179 16 such such JJ cord-023095-4dannjjm 2179 17 as as IN cord-023095-4dannjjm 2179 18 methimazole methimazole NN cord-023095-4dannjjm 2179 19 . . . cord-023095-4dannjjm 2180 1 Previously previously RB cord-023095-4dannjjm 2180 2 we -PRON- PRP cord-023095-4dannjjm 2180 3 have have VBP cord-023095-4dannjjm 2180 4 shown show VBN cord-023095-4dannjjm 2180 5 that that IN cord-023095-4dannjjm 2180 6 limiting limit VBG cord-023095-4dannjjm 2180 7 dietary dietary JJ cord-023095-4dannjjm 2180 8 iodine iodine NN cord-023095-4dannjjm 2180 9 to to IN cord-023095-4dannjjm 2180 10 or or CC cord-023095-4dannjjm 2180 11 below below IN cord-023095-4dannjjm 2180 12 0.27 0.27 CD cord-023095-4dannjjm 2180 13 ppm ppm NN cord-023095-4dannjjm 2180 14 induces induce VBZ cord-023095-4dannjjm 2180 15 euthyroidism euthyroidism NN cord-023095-4dannjjm 2180 16 in in IN cord-023095-4dannjjm 2180 17 cats cat NNS cord-023095-4dannjjm 2180 18 with with IN cord-023095-4dannjjm 2180 19 hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 2180 20 compared compare VBN cord-023095-4dannjjm 2180 21 with with IN cord-023095-4dannjjm 2180 22 a a DT cord-023095-4dannjjm 2180 23 similar similar JJ cord-023095-4dannjjm 2180 24 diet diet NN cord-023095-4dannjjm 2180 25 containing contain VBG cord-023095-4dannjjm 2180 26 0.42 0.42 CD cord-023095-4dannjjm 2180 27 ppm ppm NN cord-023095-4dannjjm 2180 28 iodine iodine NN cord-023095-4dannjjm 2180 29 . . . cord-023095-4dannjjm 2181 1 The the DT cord-023095-4dannjjm 2181 2 objective objective NN cord-023095-4dannjjm 2181 3 of of IN cord-023095-4dannjjm 2181 4 this this DT cord-023095-4dannjjm 2181 5 study study NN cord-023095-4dannjjm 2181 6 was be VBD cord-023095-4dannjjm 2181 7 to to TO cord-023095-4dannjjm 2181 8 test test VB cord-023095-4dannjjm 2181 9 whether whether IN cord-023095-4dannjjm 2181 10 dietary dietary JJ cord-023095-4dannjjm 2181 11 iodine iodine NN cord-023095-4dannjjm 2181 12 at at IN cord-023095-4dannjjm 2181 13 0.32 0.32 CD cord-023095-4dannjjm 2181 14 ppm ppm NN cord-023095-4dannjjm 2181 15 would would MD cord-023095-4dannjjm 2181 16 induce induce VB cord-023095-4dannjjm 2181 17 euthyroidism euthyroidism NN cord-023095-4dannjjm 2181 18 in in IN cord-023095-4dannjjm 2181 19 cats cat NNS cord-023095-4dannjjm 2181 20 with with IN cord-023095-4dannjjm 2181 21 naturally naturally RB cord-023095-4dannjjm 2181 22 occurring occur VBG cord-023095-4dannjjm 2181 23 hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 2181 24 . . . cord-023095-4dannjjm 2182 1 Fourteen fourteen CD cord-023095-4dannjjm 2182 2 cats cat NNS cord-023095-4dannjjm 2182 3 with with IN cord-023095-4dannjjm 2182 4 hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 2182 5 confirmed confirm VBN cord-023095-4dannjjm 2182 6 by by IN cord-023095-4dannjjm 2182 7 serum serum NN cord-023095-4dannjjm 2182 8 TT TT NNP cord-023095-4dannjjm 2182 9 4 4 CD cord-023095-4dannjjm 2182 10 and and CC cord-023095-4dannjjm 2182 11 FT FT NNP cord-023095-4dannjjm 2182 12 4 4 CD cord-023095-4dannjjm 2182 13 measurements measurement NNS cord-023095-4dannjjm 2182 14 were be VBD cord-023095-4dannjjm 2182 15 stratified stratify VBN cord-023095-4dannjjm 2182 16 into into IN cord-023095-4dannjjm 2182 17 two two CD cord-023095-4dannjjm 2182 18 groups group NNS cord-023095-4dannjjm 2182 19 based base VBN cord-023095-4dannjjm 2182 20 on on IN cord-023095-4dannjjm 2182 21 gender gender NN cord-023095-4dannjjm 2182 22 and and CC cord-023095-4dannjjm 2182 23 age age NN cord-023095-4dannjjm 2182 24 . . . cord-023095-4dannjjm 2183 1 One one CD cord-023095-4dannjjm 2183 2 group group NN cord-023095-4dannjjm 2183 3 ( ( -LRB- cord-023095-4dannjjm 2183 4 control control NN cord-023095-4dannjjm 2183 5 : : : cord-023095-4dannjjm 2183 6 4 4 CD cord-023095-4dannjjm 2183 7 males male NNS cord-023095-4dannjjm 2183 8 and and CC cord-023095-4dannjjm 2183 9 3 3 CD cord-023095-4dannjjm 2183 10 females female NNS cord-023095-4dannjjm 2183 11 , , , cord-023095-4dannjjm 2183 12 age age NN cord-023095-4dannjjm 2183 13 ranged range VBD cord-023095-4dannjjm 2183 14 from from IN cord-023095-4dannjjm 2183 15 11 11 CD cord-023095-4dannjjm 2183 16 to to TO cord-023095-4dannjjm 2183 17 15 15 CD cord-023095-4dannjjm 2183 18 years year NNS cord-023095-4dannjjm 2183 19 ) ) -RRB- cord-023095-4dannjjm 2183 20 was be VBD cord-023095-4dannjjm 2183 21 given give VBN cord-023095-4dannjjm 2183 22 a a DT cord-023095-4dannjjm 2183 23 positive positive JJ cord-023095-4dannjjm 2183 24 control control NN cord-023095-4dannjjm 2183 25 dry dry JJ cord-023095-4dannjjm 2183 26 cat cat NN cord-023095-4dannjjm 2183 27 food food NN cord-023095-4dannjjm 2183 28 ( ( -LRB- cord-023095-4dannjjm 2183 29 0.17 0.17 CD cord-023095-4dannjjm 2183 30 ppm ppm NN cord-023095-4dannjjm 2183 31 iodine iodine NN cord-023095-4dannjjm 2183 32 ) ) -RRB- cord-023095-4dannjjm 2183 33 while while IN cord-023095-4dannjjm 2183 34 the the DT cord-023095-4dannjjm 2183 35 other other JJ cord-023095-4dannjjm 2183 36 group group NN cord-023095-4dannjjm 2183 37 ( ( -LRB- cord-023095-4dannjjm 2183 38 test test NN cord-023095-4dannjjm 2183 39 : : : cord-023095-4dannjjm 2183 40 3 3 CD cord-023095-4dannjjm 2183 41 males male NNS cord-023095-4dannjjm 2183 42 and and CC cord-023095-4dannjjm 2183 43 4 4 CD cord-023095-4dannjjm 2183 44 females female NNS cord-023095-4dannjjm 2183 45 , , , cord-023095-4dannjjm 2183 46 age age NN cord-023095-4dannjjm 2183 47 ranged range VBD cord-023095-4dannjjm 2183 48 from from IN cord-023095-4dannjjm 2183 49 12 12 CD cord-023095-4dannjjm 2183 50 to to TO cord-023095-4dannjjm 2183 51 17 17 CD cord-023095-4dannjjm 2183 52 years year NNS cord-023095-4dannjjm 2183 53 ) ) -RRB- cord-023095-4dannjjm 2183 54 was be VBD cord-023095-4dannjjm 2183 55 fed feed VBN cord-023095-4dannjjm 2183 56 a a DT cord-023095-4dannjjm 2183 57 commercial commercial JJ cord-023095-4dannjjm 2183 58 dry dry JJ cord-023095-4dannjjm 2183 59 cat cat NN cord-023095-4dannjjm 2183 60 food food NN cord-023095-4dannjjm 2183 61 ( ( -LRB- cord-023095-4dannjjm 2183 62 1.9 1.9 CD cord-023095-4dannjjm 2183 63 ppm ppm NN cord-023095-4dannjjm 2183 64 iodine iodine NN cord-023095-4dannjjm 2183 65 ) ) -RRB- cord-023095-4dannjjm 2183 66 for for IN cord-023095-4dannjjm 2183 67 at at RB cord-023095-4dannjjm 2183 68 least least JJS cord-023095-4dannjjm 2183 69 6 6 CD cord-023095-4dannjjm 2183 70 weeks week NNS cord-023095-4dannjjm 2183 71 before before IN cord-023095-4dannjjm 2183 72 the the DT cord-023095-4dannjjm 2183 73 study study NN cord-023095-4dannjjm 2183 74 . . . cord-023095-4dannjjm 2184 1 Afterwards afterwards RB cord-023095-4dannjjm 2184 2 ( ( -LRB- cord-023095-4dannjjm 2184 3 week week NN cord-023095-4dannjjm 2184 4 0 0 CD cord-023095-4dannjjm 2184 5 ) ) -RRB- cord-023095-4dannjjm 2184 6 , , , cord-023095-4dannjjm 2184 7 the the DT cord-023095-4dannjjm 2184 8 control control NN cord-023095-4dannjjm 2184 9 cats cat NNS cord-023095-4dannjjm 2184 10 continued continue VBD cord-023095-4dannjjm 2184 11 to to TO cord-023095-4dannjjm 2184 12 receive receive VB cord-023095-4dannjjm 2184 13 the the DT cord-023095-4dannjjm 2184 14 same same JJ cord-023095-4dannjjm 2184 15 food food NN cord-023095-4dannjjm 2184 16 while while IN cord-023095-4dannjjm 2184 17 cats cat NNS cord-023095-4dannjjm 2184 18 in in IN cord-023095-4dannjjm 2184 19 the the DT cord-023095-4dannjjm 2184 20 test test NN cord-023095-4dannjjm 2184 21 group group NN cord-023095-4dannjjm 2184 22 were be VBD cord-023095-4dannjjm 2184 23 given give VBN cord-023095-4dannjjm 2184 24 a a DT cord-023095-4dannjjm 2184 25 test test NN cord-023095-4dannjjm 2184 26 food food NN cord-023095-4dannjjm 2184 27 ( ( -LRB- cord-023095-4dannjjm 2184 28 0.32 0.32 CD cord-023095-4dannjjm 2184 29 ppm ppm NN cord-023095-4dannjjm 2184 30 iodine iodine NN cord-023095-4dannjjm 2184 31 ) ) -RRB- cord-023095-4dannjjm 2184 32 for for IN cord-023095-4dannjjm 2184 33 additional additional JJ cord-023095-4dannjjm 2184 34 12 12 CD cord-023095-4dannjjm 2184 35 weeks week NNS cord-023095-4dannjjm 2184 36 . . . cord-023095-4dannjjm 2185 1 All all DT cord-023095-4dannjjm 2185 2 cats cat NNS cord-023095-4dannjjm 2185 3 had have VBD cord-023095-4dannjjm 2185 4 free free JJ cord-023095-4dannjjm 2185 5 access access NN cord-023095-4dannjjm 2185 6 to to IN cord-023095-4dannjjm 2185 7 their -PRON- PRP$ cord-023095-4dannjjm 2185 8 food food NN cord-023095-4dannjjm 2185 9 and and CC cord-023095-4dannjjm 2185 10 deionized deionize VBN cord-023095-4dannjjm 2185 11 water water NN cord-023095-4dannjjm 2185 12 during during IN cord-023095-4dannjjm 2185 13 the the DT cord-023095-4dannjjm 2185 14 study study NN cord-023095-4dannjjm 2185 15 . . . cord-023095-4dannjjm 2186 1 Blood blood NN cord-023095-4dannjjm 2186 2 samples sample NNS cord-023095-4dannjjm 2186 3 were be VBD cord-023095-4dannjjm 2186 4 collected collect VBN cord-023095-4dannjjm 2186 5 during during IN cord-023095-4dannjjm 2186 6 weeks week NNS cord-023095-4dannjjm 2186 7 0 0 CD cord-023095-4dannjjm 2186 8 , , , cord-023095-4dannjjm 2186 9 3 3 CD cord-023095-4dannjjm 2186 10 , , , cord-023095-4dannjjm 2186 11 6 6 CD cord-023095-4dannjjm 2186 12 , , , cord-023095-4dannjjm 2186 13 and and CC cord-023095-4dannjjm 2186 14 12 12 CD cord-023095-4dannjjm 2186 15 of of IN cord-023095-4dannjjm 2186 16 the the DT cord-023095-4dannjjm 2186 17 study study NN cord-023095-4dannjjm 2186 18 . . . cord-023095-4dannjjm 2187 1 The the DT cord-023095-4dannjjm 2187 2 control control NN cord-023095-4dannjjm 2187 3 cats cat NNS cord-023095-4dannjjm 2187 4 maintained maintain VBD cord-023095-4dannjjm 2187 5 euthyroidism euthyroidism NN cord-023095-4dannjjm 2187 6 during during IN cord-023095-4dannjjm 2187 7 the the DT cord-023095-4dannjjm 2187 8 study study NN cord-023095-4dannjjm 2187 9 . . . cord-023095-4dannjjm 2188 1 The the DT cord-023095-4dannjjm 2188 2 test test NN cord-023095-4dannjjm 2188 3 food food NN cord-023095-4dannjjm 2188 4 significantly significantly RB cord-023095-4dannjjm 2188 5 reduced reduce VBD cord-023095-4dannjjm 2188 6 serum serum NN cord-023095-4dannjjm 2188 7 TT TT NNP cord-023095-4dannjjm 2188 8 4 4 CD cord-023095-4dannjjm 2188 9 ( ( -LRB- cord-023095-4dannjjm 2188 10 72 72 CD cord-023095-4dannjjm 2188 11 AE AE NNP cord-023095-4dannjjm 2188 12 12 12 CD cord-023095-4dannjjm 2188 13 , , , cord-023095-4dannjjm 2188 14 43 43 CD cord-023095-4dannjjm 2188 15 AE AE NNP cord-023095-4dannjjm 2188 16 9 9 CD cord-023095-4dannjjm 2188 17 Ã Ã NNP cord-023095-4dannjjm 2188 18 , , , cord-023095-4dannjjm 2188 19 42 42 CD cord-023095-4dannjjm 2188 20 AE AE NNP cord-023095-4dannjjm 2188 21 9 9 CD cord-023095-4dannjjm 2188 22 Ã Ã NNP cord-023095-4dannjjm 2188 23 , , , cord-023095-4dannjjm 2188 24 40 40 CD cord-023095-4dannjjm 2188 25 AE AE NNP cord-023095-4dannjjm 2188 26 6 6 CD cord-023095-4dannjjm 2188 27 Ã ã NN cord-023095-4dannjjm 2188 28 nmol nmol NN cord-023095-4dannjjm 2188 29 / / SYM cord-023095-4dannjjm 2188 30 L l NN cord-023095-4dannjjm 2188 31 in in IN cord-023095-4dannjjm 2188 32 weeks week NNS cord-023095-4dannjjm 2188 33 0 0 CD cord-023095-4dannjjm 2188 34 , , , cord-023095-4dannjjm 2188 35 3 3 CD cord-023095-4dannjjm 2188 36 , , , cord-023095-4dannjjm 2188 37 6 6 CD cord-023095-4dannjjm 2188 38 and and CC cord-023095-4dannjjm 2188 39 12 12 CD cord-023095-4dannjjm 2188 40 , , , cord-023095-4dannjjm 2188 41 respectively respectively RB cord-023095-4dannjjm 2188 42 ; ; : cord-023095-4dannjjm 2188 43 Ã ã NN cord-023095-4dannjjm 2188 44 : : : cord-023095-4dannjjm 2188 45 p p NN cord-023095-4dannjjm 2188 46 o o NN cord-023095-4dannjjm 2188 47 0.05 0.05 CD cord-023095-4dannjjm 2188 48 compared compare VBN cord-023095-4dannjjm 2188 49 with with IN cord-023095-4dannjjm 2188 50 week week NN cord-023095-4dannjjm 2188 51 0 0 CD cord-023095-4dannjjm 2188 52 , , , cord-023095-4dannjjm 2188 53 Dunnett Dunnett NNP cord-023095-4dannjjm 2188 54 's 's POS cord-023095-4dannjjm 2188 55 t t NN cord-023095-4dannjjm 2188 56 test test NN cord-023095-4dannjjm 2188 57 ) ) -RRB- cord-023095-4dannjjm 2188 58 . . . cord-023095-4dannjjm 2189 1 It -PRON- PRP cord-023095-4dannjjm 2189 2 also also RB cord-023095-4dannjjm 2189 3 significantly significantly RB cord-023095-4dannjjm 2189 4 reduced reduce VBD cord-023095-4dannjjm 2189 5 FT FT NNP cord-023095-4dannjjm 2189 6 4 4 CD cord-023095-4dannjjm 2189 7 at at IN cord-023095-4dannjjm 2189 8 the the DT cord-023095-4dannjjm 2189 9 end end NN cord-023095-4dannjjm 2189 10 of of IN cord-023095-4dannjjm 2189 11 the the DT cord-023095-4dannjjm 2189 12 study study NN cord-023095-4dannjjm 2189 13 ( ( -LRB- cord-023095-4dannjjm 2189 14 17 17 CD cord-023095-4dannjjm 2189 15 AE AE NNP cord-023095-4dannjjm 2189 16 2 2 CD cord-023095-4dannjjm 2189 17 vs. vs. NN cord-023095-4dannjjm 2189 18 23AE 23ae CD cord-023095-4dannjjm 2189 19 2 2 CD cord-023095-4dannjjm 2189 20 pmol pmol NN cord-023095-4dannjjm 2189 21 , , , cord-023095-4dannjjm 2189 22 week week NN cord-023095-4dannjjm 2189 23 12 12 CD cord-023095-4dannjjm 2189 24 vs. vs. IN cord-023095-4dannjjm 2189 25 week week NN cord-023095-4dannjjm 2189 26 0 0 CD cord-023095-4dannjjm 2189 27 ; ; : cord-023095-4dannjjm 2189 28 Dunnett Dunnett NNP cord-023095-4dannjjm 2189 29 's 's POS cord-023095-4dannjjm 2189 30 t t NN cord-023095-4dannjjm 2189 31 test test NN cord-023095-4dannjjm 2189 32 , , , cord-023095-4dannjjm 2189 33 p p NN cord-023095-4dannjjm 2189 34 o o NN cord-023095-4dannjjm 2189 35 0.05 0.05 CD cord-023095-4dannjjm 2189 36 ) ) -RRB- cord-023095-4dannjjm 2189 37 . . . cord-023095-4dannjjm 2190 1 Serum serum NN cord-023095-4dannjjm 2190 2 FT FT NNP cord-023095-4dannjjm 2190 3 4 4 CD cord-023095-4dannjjm 2190 4 was be VBD cord-023095-4dannjjm 2190 5 within within IN cord-023095-4dannjjm 2190 6 the the DT cord-023095-4dannjjm 2190 7 reference reference NN cord-023095-4dannjjm 2190 8 range range NN cord-023095-4dannjjm 2190 9 ( ( -LRB- cord-023095-4dannjjm 2190 10 10 10 CD cord-023095-4dannjjm 2190 11 - - SYM cord-023095-4dannjjm 2190 12 55 55 CD cord-023095-4dannjjm 2190 13 pmol pmol NN cord-023095-4dannjjm 2190 14 / / SYM cord-023095-4dannjjm 2190 15 L l NN cord-023095-4dannjjm 2190 16 ) ) -RRB- cord-023095-4dannjjm 2190 17 in in IN cord-023095-4dannjjm 2190 18 cats cat NNS cord-023095-4dannjjm 2190 19 in in IN cord-023095-4dannjjm 2190 20 both both DT cord-023095-4dannjjm 2190 21 groups group NNS cord-023095-4dannjjm 2190 22 . . . cord-023095-4dannjjm 2191 1 Serum serum NN cord-023095-4dannjjm 2191 2 TT TT NNP cord-023095-4dannjjm 2191 3 3 3 CD cord-023095-4dannjjm 2191 4 , , , cord-023095-4dannjjm 2191 5 FT FT NNP cord-023095-4dannjjm 2191 6 3 3 CD cord-023095-4dannjjm 2191 7 , , , cord-023095-4dannjjm 2191 8 and and CC cord-023095-4dannjjm 2191 9 TSH TSH NNP cord-023095-4dannjjm 2191 10 were be VBD cord-023095-4dannjjm 2191 11 not not RB cord-023095-4dannjjm 2191 12 affected affect VBN cord-023095-4dannjjm 2191 13 by by IN cord-023095-4dannjjm 2191 14 the the DT cord-023095-4dannjjm 2191 15 test test NN cord-023095-4dannjjm 2191 16 food food NN cord-023095-4dannjjm 2191 17 and and CC cord-023095-4dannjjm 2191 18 were be VBD cord-023095-4dannjjm 2191 19 within within IN cord-023095-4dannjjm 2191 20 the the DT cord-023095-4dannjjm 2191 21 reference reference NN cord-023095-4dannjjm 2191 22 ranges range VBZ cord-023095-4dannjjm 2192 1 ( ( -LRB- cord-023095-4dannjjm 2192 2 TT TT NNP cord-023095-4dannjjm 2192 3 3 3 CD cord-023095-4dannjjm 2192 4 : : : cord-023095-4dannjjm 2192 5 0.6 0.6 CD cord-023095-4dannjjm 2192 6 - - SYM cord-023095-4dannjjm 2192 7 1.4 1.4 CD cord-023095-4dannjjm 2192 8 nmol nmol NNP cord-023095-4dannjjm 2192 9 / / SYM cord-023095-4dannjjm 2192 10 L L NNP cord-023095-4dannjjm 2192 11 , , , cord-023095-4dannjjm 2192 12 FT FT NNP cord-023095-4dannjjm 2192 13 3 3 CD cord-023095-4dannjjm 2192 14 : : : cord-023095-4dannjjm 2192 15 1.5 1.5 CD cord-023095-4dannjjm 2192 16 - - SYM cord-023095-4dannjjm 2192 17 6 6 CD cord-023095-4dannjjm 2192 18 pmol pmol NN cord-023095-4dannjjm 2192 19 / / SYM cord-023095-4dannjjm 2192 20 L l NN cord-023095-4dannjjm 2192 21 , , , cord-023095-4dannjjm 2192 22 and and CC cord-023095-4dannjjm 2192 23 TSH tsh NN cord-023095-4dannjjm 2192 24 : : : cord-023095-4dannjjm 2192 25 0 0 CD cord-023095-4dannjjm 2192 26 - - SYM cord-023095-4dannjjm 2192 27 21 21 CD cord-023095-4dannjjm 2192 28 mU mU NNS cord-023095-4dannjjm 2192 29 / / SYM cord-023095-4dannjjm 2192 30 L l NN cord-023095-4dannjjm 2192 31 ) ) -RRB- cord-023095-4dannjjm 2193 1 in in IN cord-023095-4dannjjm 2193 2 cats cat NNS cord-023095-4dannjjm 2193 3 of of IN cord-023095-4dannjjm 2193 4 both both DT cord-023095-4dannjjm 2193 5 groups group NNS cord-023095-4dannjjm 2193 6 during during IN cord-023095-4dannjjm 2193 7 the the DT cord-023095-4dannjjm 2193 8 study study NN cord-023095-4dannjjm 2193 9 . . . cord-023095-4dannjjm 2194 1 This this DT cord-023095-4dannjjm 2194 2 study study NN cord-023095-4dannjjm 2194 3 demonstrates demonstrate VBZ cord-023095-4dannjjm 2194 4 that that IN cord-023095-4dannjjm 2194 5 dietary dietary JJ cord-023095-4dannjjm 2194 6 iodine iodine NN cord-023095-4dannjjm 2194 7 at at IN cord-023095-4dannjjm 2194 8 or or CC cord-023095-4dannjjm 2194 9 below below IN cord-023095-4dannjjm 2194 10 0.32 0.32 CD cord-023095-4dannjjm 2194 11 ppm ppm NN cord-023095-4dannjjm 2194 12 provides provide VBZ cord-023095-4dannjjm 2194 13 an an DT cord-023095-4dannjjm 2194 14 effective effective JJ cord-023095-4dannjjm 2194 15 and and CC cord-023095-4dannjjm 2194 16 inexpensive inexpensive JJ cord-023095-4dannjjm 2194 17 therapy therapy NN cord-023095-4dannjjm 2194 18 for for IN cord-023095-4dannjjm 2194 19 cats cat NNS cord-023095-4dannjjm 2194 20 with with IN cord-023095-4dannjjm 2194 21 naturally naturally RB cord-023095-4dannjjm 2194 22 occurring occur VBG cord-023095-4dannjjm 2194 23 hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 2194 24 . . . cord-023095-4dannjjm 2195 1 Radioactive radioactive JJ cord-023095-4dannjjm 2195 2 iodine iodine NN cord-023095-4dannjjm 2195 3 ( ( -LRB- cord-023095-4dannjjm 2195 4 131 131 CD cord-023095-4dannjjm 2195 5 I i NN cord-023095-4dannjjm 2195 6 ) ) -RRB- cord-023095-4dannjjm 2195 7 is be VBZ cord-023095-4dannjjm 2195 8 a a DT cord-023095-4dannjjm 2195 9 widely widely RB cord-023095-4dannjjm 2195 10 used use VBN cord-023095-4dannjjm 2195 11 treatment treatment NN cord-023095-4dannjjm 2195 12 for for IN cord-023095-4dannjjm 2195 13 feline feline JJ cord-023095-4dannjjm 2195 14 hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 2195 15 . . . cord-023095-4dannjjm 2196 1 Prior prior RB cord-023095-4dannjjm 2196 2 to to IN cord-023095-4dannjjm 2196 3 131 131 CD cord-023095-4dannjjm 2196 4 I I NNP cord-023095-4dannjjm 2196 5 administration administration NN cord-023095-4dannjjm 2196 6 , , , cord-023095-4dannjjm 2196 7 many many JJ cord-023095-4dannjjm 2196 8 cats cat NNS cord-023095-4dannjjm 2196 9 receive receive VBP cord-023095-4dannjjm 2196 10 methimazole methimazole NN cord-023095-4dannjjm 2196 11 therapy therapy NN cord-023095-4dannjjm 2196 12 . . . cord-023095-4dannjjm 2197 1 It -PRON- PRP cord-023095-4dannjjm 2197 2 has have VBZ cord-023095-4dannjjm 2197 3 been be VBN cord-023095-4dannjjm 2197 4 suggested suggest VBN cord-023095-4dannjjm 2197 5 that that IN cord-023095-4dannjjm 2197 6 recent recent JJ cord-023095-4dannjjm 2197 7 withdrawal withdrawal NN cord-023095-4dannjjm 2197 8 of of IN cord-023095-4dannjjm 2197 9 methimazole methimazole NN cord-023095-4dannjjm 2197 10 prior prior RB cord-023095-4dannjjm 2197 11 to to IN cord-023095-4dannjjm 2197 12 131 131 CD cord-023095-4dannjjm 2197 13 I -PRON- PRP cord-023095-4dannjjm 2197 14 may may MD cord-023095-4dannjjm 2197 15 increase increase VB cord-023095-4dannjjm 2197 16 the the DT cord-023095-4dannjjm 2197 17 risk risk NN cord-023095-4dannjjm 2197 18 of of IN cord-023095-4dannjjm 2197 19 hypothyroidism hypothyroidism NN cord-023095-4dannjjm 2197 20 , , , cord-023095-4dannjjm 2197 21 inhibit inhibit VB cord-023095-4dannjjm 2197 22 the the DT cord-023095-4dannjjm 2197 23 response response NN cord-023095-4dannjjm 2197 24 to to IN cord-023095-4dannjjm 2197 25 therapy therapy NN cord-023095-4dannjjm 2197 26 , , , cord-023095-4dannjjm 2197 27 or or CC cord-023095-4dannjjm 2197 28 have have VBP cord-023095-4dannjjm 2197 29 no no DT cord-023095-4dannjjm 2197 30 effect effect NN cord-023095-4dannjjm 2197 31 . . . cord-023095-4dannjjm 2198 1 To to TO cord-023095-4dannjjm 2198 2 further further RB cord-023095-4dannjjm 2198 3 address address VB cord-023095-4dannjjm 2198 4 this this DT cord-023095-4dannjjm 2198 5 question question NN cord-023095-4dannjjm 2198 6 , , , cord-023095-4dannjjm 2198 7 a a DT cord-023095-4dannjjm 2198 8 retrospective retrospective JJ cord-023095-4dannjjm 2198 9 medical medical JJ cord-023095-4dannjjm 2198 10 records record NNS cord-023095-4dannjjm 2198 11 search search NN cord-023095-4dannjjm 2198 12 was be VBD cord-023095-4dannjjm 2198 13 performed perform VBN cord-023095-4dannjjm 2198 14 to to TO cord-023095-4dannjjm 2198 15 identify identify VB cord-023095-4dannjjm 2198 16 hyperthyroid hyperthyroid JJ cord-023095-4dannjjm 2198 17 cats cat NNS cord-023095-4dannjjm 2198 18 that that WDT cord-023095-4dannjjm 2198 19 received receive VBD cord-023095-4dannjjm 2198 20 131 131 CD cord-023095-4dannjjm 2198 21 I I NNP cord-023095-4dannjjm 2198 22 therapy therapy NN cord-023095-4dannjjm 2198 23 after after IN cord-023095-4dannjjm 2198 24 methimazole methimazole NN cord-023095-4dannjjm 2198 25 treatment treatment NN cord-023095-4dannjjm 2198 26 . . . cord-023095-4dannjjm 2199 1 Inclusion inclusion NN cord-023095-4dannjjm 2199 2 criteria criterion NNS cord-023095-4dannjjm 2199 3 included include VBD cord-023095-4dannjjm 2199 4 documentation documentation NN cord-023095-4dannjjm 2199 5 of of IN cord-023095-4dannjjm 2199 6 the the DT cord-023095-4dannjjm 2199 7 time time NN cord-023095-4dannjjm 2199 8 interval interval NN cord-023095-4dannjjm 2199 9 between between IN cord-023095-4dannjjm 2199 10 discontinuation discontinuation NN cord-023095-4dannjjm 2199 11 of of IN cord-023095-4dannjjm 2199 12 methimazole methimazole NN cord-023095-4dannjjm 2199 13 and and CC cord-023095-4dannjjm 2199 14 131 131 CD cord-023095-4dannjjm 2199 15 I I NNP cord-023095-4dannjjm 2199 16 administration administration NN cord-023095-4dannjjm 2199 17 , , , cord-023095-4dannjjm 2199 18 and and CC cord-023095-4dannjjm 2199 19 measurement measurement NN cord-023095-4dannjjm 2199 20 of of IN cord-023095-4dannjjm 2199 21 thyroxine thyroxine NN cord-023095-4dannjjm 2199 22 ( ( -LRB- cord-023095-4dannjjm 2199 23 T T NNP cord-023095-4dannjjm 2199 24 4 4 CD cord-023095-4dannjjm 2199 25 ) ) -RRB- cord-023095-4dannjjm 2199 26 at at IN cord-023095-4dannjjm 2199 27 7 7 CD cord-023095-4dannjjm 2199 28 - - SYM cord-023095-4dannjjm 2199 29 14 14 CD cord-023095-4dannjjm 2199 30 days day NNS cord-023095-4dannjjm 2199 31 after after IN cord-023095-4dannjjm 2199 32 131 131 CD cord-023095-4dannjjm 2199 33 I. I. NNP cord-023095-4dannjjm 2199 34 Cats cat NNS cord-023095-4dannjjm 2199 35 were be VBD cord-023095-4dannjjm 2199 36 divided divide VBN cord-023095-4dannjjm 2199 37 into into IN cord-023095-4dannjjm 2199 38 2 2 CD cord-023095-4dannjjm 2199 39 groups group NNS cord-023095-4dannjjm 2199 40 : : : cord-023095-4dannjjm 2199 41 those those DT cord-023095-4dannjjm 2199 42 receiving receive VBG cord-023095-4dannjjm 2199 43 131 131 CD cord-023095-4dannjjm 2199 44 I -PRON- PRP cord-023095-4dannjjm 2199 45 within within IN cord-023095-4dannjjm 2199 46 1 1 CD cord-023095-4dannjjm 2199 47 day day NN cord-023095-4dannjjm 2199 48 of of IN cord-023095-4dannjjm 2199 49 stopping stop VBG cord-023095-4dannjjm 2199 50 methimazole methimazole NN cord-023095-4dannjjm 2199 51 , , , cord-023095-4dannjjm 2199 52 and and CC cord-023095-4dannjjm 2199 53 those those DT cord-023095-4dannjjm 2199 54 receiving receive VBG cord-023095-4dannjjm 2199 55 131 131 CD cord-023095-4dannjjm 2199 56 I I NNP cord-023095-4dannjjm 2199 57 treatment treatment NN cord-023095-4dannjjm 2199 58 5 5 CD cord-023095-4dannjjm 2199 59 or or CC cord-023095-4dannjjm 2199 60 more more JJR cord-023095-4dannjjm 2199 61 days day NNS cord-023095-4dannjjm 2199 62 after after IN cord-023095-4dannjjm 2199 63 stopping stop VBG cord-023095-4dannjjm 2199 64 methimazole methimazole NN cord-023095-4dannjjm 2199 65 . . . cord-023095-4dannjjm 2200 1 Sixty sixty JJ cord-023095-4dannjjm 2200 2 cats cat NNS cord-023095-4dannjjm 2200 3 met meet VBD cord-023095-4dannjjm 2200 4 the the DT cord-023095-4dannjjm 2200 5 inclusion inclusion NN cord-023095-4dannjjm 2200 6 criteria criterion NNS cord-023095-4dannjjm 2200 7 . . . cord-023095-4dannjjm 2201 1 Forty forty CD cord-023095-4dannjjm 2201 2 received receive VBD cord-023095-4dannjjm 2201 3 131 131 CD cord-023095-4dannjjm 2201 4 I -PRON- PRP cord-023095-4dannjjm 2201 5 within within IN cord-023095-4dannjjm 2201 6 1 1 CD cord-023095-4dannjjm 2201 7 day day NN cord-023095-4dannjjm 2201 8 of of IN cord-023095-4dannjjm 2201 9 stopping stop VBG cord-023095-4dannjjm 2201 10 methimazole methimazole NN cord-023095-4dannjjm 2201 11 . . . cord-023095-4dannjjm 2202 1 Of of IN cord-023095-4dannjjm 2202 2 those those DT cord-023095-4dannjjm 2202 3 , , , cord-023095-4dannjjm 2202 4 20 20 CD cord-023095-4dannjjm 2202 5 ( ( -LRB- cord-023095-4dannjjm 2202 6 50 50 CD cord-023095-4dannjjm 2202 7 % % NN cord-023095-4dannjjm 2202 8 ) ) -RRB- cord-023095-4dannjjm 2202 9 had have VBD cord-023095-4dannjjm 2202 10 a a DT cord-023095-4dannjjm 2202 11 low low JJ cord-023095-4dannjjm 2202 12 T4 T4 NNP cord-023095-4dannjjm 2202 13 ( ( -LRB- cord-023095-4dannjjm 2202 14 o o NNP cord-023095-4dannjjm 2202 15 1.2 1.2 CD cord-023095-4dannjjm 2202 16 mcg mcg NNP cord-023095-4dannjjm 2202 17 / / SYM cord-023095-4dannjjm 2202 18 dl dl NNP cord-023095-4dannjjm 2202 19 ) ) -RRB- cord-023095-4dannjjm 2202 20 , , , cord-023095-4dannjjm 2202 21 17 17 CD cord-023095-4dannjjm 2202 22 ( ( -LRB- cord-023095-4dannjjm 2202 23 42.5 42.5 CD cord-023095-4dannjjm 2202 24 % % NN cord-023095-4dannjjm 2202 25 ) ) -RRB- cord-023095-4dannjjm 2202 26 had have VBD cord-023095-4dannjjm 2202 27 a a DT cord-023095-4dannjjm 2202 28 normal normal JJ cord-023095-4dannjjm 2202 29 T4 t4 NN cord-023095-4dannjjm 2202 30 ( ( -LRB- cord-023095-4dannjjm 2202 31 1.2 1.2 CD cord-023095-4dannjjm 2202 32 - - SYM cord-023095-4dannjjm 2202 33 4.8 4.8 CD cord-023095-4dannjjm 2202 34 mcg mcg NNP cord-023095-4dannjjm 2202 35 / / SYM cord-023095-4dannjjm 2202 36 dl dl NNP cord-023095-4dannjjm 2202 37 ) ) -RRB- cord-023095-4dannjjm 2202 38 , , , cord-023095-4dannjjm 2202 39 and and CC cord-023095-4dannjjm 2202 40 3 3 CD cord-023095-4dannjjm 2202 41 ( ( -LRB- cord-023095-4dannjjm 2202 42 7.5 7.5 CD cord-023095-4dannjjm 2202 43 % % NN cord-023095-4dannjjm 2202 44 ) ) -RRB- cord-023095-4dannjjm 2202 45 had have VBD cord-023095-4dannjjm 2202 46 an an DT cord-023095-4dannjjm 2202 47 elevated elevated JJ cord-023095-4dannjjm 2202 48 T4 t4 NN cord-023095-4dannjjm 2202 49 ( ( -LRB- cord-023095-4dannjjm 2202 50 4 4 CD cord-023095-4dannjjm 2202 51 4.8 4.8 CD cord-023095-4dannjjm 2202 52 mcg mcg NNP cord-023095-4dannjjm 2202 53 / / SYM cord-023095-4dannjjm 2202 54 dl dl NN cord-023095-4dannjjm 2202 55 ) ) -RRB- cord-023095-4dannjjm 2202 56 at at IN cord-023095-4dannjjm 2202 57 7 7 CD cord-023095-4dannjjm 2202 58 - - SYM cord-023095-4dannjjm 2202 59 14 14 CD cord-023095-4dannjjm 2202 60 days day NNS cord-023095-4dannjjm 2202 61 after after IN cord-023095-4dannjjm 2202 62 131 131 CD cord-023095-4dannjjm 2202 63 I i NN cord-023095-4dannjjm 2202 64 therapy therapy NN cord-023095-4dannjjm 2202 65 . . . cord-023095-4dannjjm 2203 1 Fourteen fourteen CD cord-023095-4dannjjm 2203 2 cats cat NNS cord-023095-4dannjjm 2203 3 received receive VBD cord-023095-4dannjjm 2203 4 131 131 CD cord-023095-4dannjjm 2203 5 I -PRON- PRP cord-023095-4dannjjm 2203 6 5 5 CD cord-023095-4dannjjm 2203 7 or or CC cord-023095-4dannjjm 2203 8 more more JJR cord-023095-4dannjjm 2203 9 days day NNS cord-023095-4dannjjm 2203 10 after after IN cord-023095-4dannjjm 2203 11 stopping stop VBG cord-023095-4dannjjm 2203 12 methimazole methimazole NN cord-023095-4dannjjm 2203 13 : : : cord-023095-4dannjjm 2203 14 8 8 CD cord-023095-4dannjjm 2203 15 ( ( -LRB- cord-023095-4dannjjm 2203 16 57 57 CD cord-023095-4dannjjm 2203 17 % % NN cord-023095-4dannjjm 2203 18 ) ) -RRB- cord-023095-4dannjjm 2203 19 had have VBD cord-023095-4dannjjm 2203 20 a a DT cord-023095-4dannjjm 2203 21 low low JJ cord-023095-4dannjjm 2203 22 T T NNP cord-023095-4dannjjm 2203 23 4 4 CD cord-023095-4dannjjm 2203 24 , , , cord-023095-4dannjjm 2203 25 5 5 CD cord-023095-4dannjjm 2203 26 ( ( -LRB- cord-023095-4dannjjm 2203 27 36 36 CD cord-023095-4dannjjm 2203 28 % % NN cord-023095-4dannjjm 2203 29 ) ) -RRB- cord-023095-4dannjjm 2203 30 had have VBD cord-023095-4dannjjm 2203 31 a a DT cord-023095-4dannjjm 2203 32 normal normal JJ cord-023095-4dannjjm 2203 33 T t NN cord-023095-4dannjjm 2203 34 4 4 CD cord-023095-4dannjjm 2203 35 , , , cord-023095-4dannjjm 2203 36 and and CC cord-023095-4dannjjm 2203 37 1 1 CD cord-023095-4dannjjm 2203 38 ( ( -LRB- cord-023095-4dannjjm 2203 39 7 7 CD cord-023095-4dannjjm 2203 40 % % NN cord-023095-4dannjjm 2203 41 ) ) -RRB- cord-023095-4dannjjm 2203 42 had have VBD cord-023095-4dannjjm 2203 43 an an DT cord-023095-4dannjjm 2203 44 elevated elevated JJ cord-023095-4dannjjm 2203 45 T t NN cord-023095-4dannjjm 2203 46 4 4 CD cord-023095-4dannjjm 2203 47 at at IN cord-023095-4dannjjm 2203 48 7 7 CD cord-023095-4dannjjm 2203 49 - - SYM cord-023095-4dannjjm 2203 50 14 14 CD cord-023095-4dannjjm 2203 51 days day NNS cord-023095-4dannjjm 2203 52 after after IN cord-023095-4dannjjm 2203 53 131 131 CD cord-023095-4dannjjm 2204 1 I -PRON- PRP cord-023095-4dannjjm 2204 2 therapy therapy NN cord-023095-4dannjjm 2204 3 . . . cord-023095-4dannjjm 2205 1 The the DT cord-023095-4dannjjm 2205 2 results result NNS cord-023095-4dannjjm 2205 3 were be VBD cord-023095-4dannjjm 2205 4 compared compare VBN cord-023095-4dannjjm 2205 5 with with IN cord-023095-4dannjjm 2205 6 a a DT cord-023095-4dannjjm 2205 7 Fisher Fisher NNP cord-023095-4dannjjm 2205 8 's 's POS cord-023095-4dannjjm 2205 9 exact exact JJ cord-023095-4dannjjm 2205 10 test test NN cord-023095-4dannjjm 2205 11 and and CC cord-023095-4dannjjm 2205 12 there there EX cord-023095-4dannjjm 2205 13 was be VBD cord-023095-4dannjjm 2205 14 no no DT cord-023095-4dannjjm 2205 15 difference difference NN cord-023095-4dannjjm 2205 16 between between IN cord-023095-4dannjjm 2205 17 the the DT cord-023095-4dannjjm 2205 18 groups group NNS cord-023095-4dannjjm 2205 19 ( ( -LRB- cord-023095-4dannjjm 2205 20 p p NN cord-023095-4dannjjm 2205 21 5 5 CD cord-023095-4dannjjm 2205 22 0.76 0.76 CD cord-023095-4dannjjm 2205 23 ) ) -RRB- cord-023095-4dannjjm 2205 24 . . . cord-023095-4dannjjm 2206 1 These these DT cord-023095-4dannjjm 2206 2 findings finding NNS cord-023095-4dannjjm 2206 3 indicate indicate VBP cord-023095-4dannjjm 2206 4 that that IN cord-023095-4dannjjm 2206 5 stopping stop VBG cord-023095-4dannjjm 2206 6 methimazole methimazole NN cord-023095-4dannjjm 2206 7 therapy therapy NN cord-023095-4dannjjm 2206 8 within within IN cord-023095-4dannjjm 2206 9 1 1 CD cord-023095-4dannjjm 2206 10 day day NN cord-023095-4dannjjm 2206 11 of of IN cord-023095-4dannjjm 2206 12 131 131 CD cord-023095-4dannjjm 2206 13 I i NN cord-023095-4dannjjm 2206 14 therapy therapy NN cord-023095-4dannjjm 2206 15 does do VBZ cord-023095-4dannjjm 2206 16 not not RB cord-023095-4dannjjm 2206 17 inhibit inhibit VB cord-023095-4dannjjm 2206 18 the the DT cord-023095-4dannjjm 2206 19 response response NN cord-023095-4dannjjm 2206 20 to to IN cord-023095-4dannjjm 2206 21 therapy therapy NN cord-023095-4dannjjm 2206 22 . . . cord-023095-4dannjjm 2207 1 Pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 2207 2 studies study NNS cord-023095-4dannjjm 2207 3 evaluating evaluate VBG cord-023095-4dannjjm 2207 4 synthetic synthetic JJ cord-023095-4dannjjm 2207 5 insulin insulin NN cord-023095-4dannjjm 2207 6 analogs analog NNS cord-023095-4dannjjm 2207 7 such such JJ cord-023095-4dannjjm 2207 8 as as IN cord-023095-4dannjjm 2207 9 glargine glargine NNP cord-023095-4dannjjm 2207 10 necessitate necessitate VBP cord-023095-4dannjjm 2207 11 the the DT cord-023095-4dannjjm 2207 12 ability ability NN cord-023095-4dannjjm 2207 13 to to TO cord-023095-4dannjjm 2207 14 measure measure VB cord-023095-4dannjjm 2207 15 the the DT cord-023095-4dannjjm 2207 16 blood blood NN cord-023095-4dannjjm 2207 17 concentrations concentration NNS cord-023095-4dannjjm 2207 18 of of IN cord-023095-4dannjjm 2207 19 glargine glargine NNP cord-023095-4dannjjm 2207 20 without without IN cord-023095-4dannjjm 2207 21 cross cross NN cord-023095-4dannjjm 2207 22 - - NN cord-023095-4dannjjm 2207 23 reactivity reactivity NN cord-023095-4dannjjm 2207 24 to to IN cord-023095-4dannjjm 2207 25 endogenous endogenous JJ cord-023095-4dannjjm 2207 26 insulin insulin NN cord-023095-4dannjjm 2207 27 . . . cord-023095-4dannjjm 2208 1 Although although IN cord-023095-4dannjjm 2208 2 the the DT cord-023095-4dannjjm 2208 3 cross cross NN cord-023095-4dannjjm 2208 4 - - NN cord-023095-4dannjjm 2208 5 reactivity reactivity NN cord-023095-4dannjjm 2208 6 between between IN cord-023095-4dannjjm 2208 7 endogenous endogenous JJ cord-023095-4dannjjm 2208 8 human human JJ cord-023095-4dannjjm 2208 9 insulin insulin NN cord-023095-4dannjjm 2208 10 assays assay NNS cord-023095-4dannjjm 2208 11 and and CC cord-023095-4dannjjm 2208 12 synthetic synthetic JJ cord-023095-4dannjjm 2208 13 analogs analog NNS cord-023095-4dannjjm 2208 14 is be VBZ cord-023095-4dannjjm 2208 15 often often RB cord-023095-4dannjjm 2208 16 known know VBN cord-023095-4dannjjm 2208 17 for for IN cord-023095-4dannjjm 2208 18 commerciallyavailable commerciallyavailable JJ cord-023095-4dannjjm 2208 19 assays assay NNS cord-023095-4dannjjm 2208 20 , , , cord-023095-4dannjjm 2208 21 the the DT cord-023095-4dannjjm 2208 22 degree degree NN cord-023095-4dannjjm 2208 23 of of IN cord-023095-4dannjjm 2208 24 cross cross NN cord-023095-4dannjjm 2208 25 - - NN cord-023095-4dannjjm 2208 26 reactivity reactivity NN cord-023095-4dannjjm 2208 27 of of IN cord-023095-4dannjjm 2208 28 human human JJ cord-023095-4dannjjm 2208 29 insulin insulin NN cord-023095-4dannjjm 2208 30 assays assay NNS cord-023095-4dannjjm 2208 31 with with IN cord-023095-4dannjjm 2208 32 feline feline JJ cord-023095-4dannjjm 2208 33 insulin insulin NN cord-023095-4dannjjm 2208 34 is be VBZ cord-023095-4dannjjm 2208 35 not not RB cord-023095-4dannjjm 2208 36 . . . cord-023095-4dannjjm 2209 1 The the DT cord-023095-4dannjjm 2209 2 purpose purpose NN cord-023095-4dannjjm 2209 3 of of IN cord-023095-4dannjjm 2209 4 this this DT cord-023095-4dannjjm 2209 5 study study NN cord-023095-4dannjjm 2209 6 was be VBD cord-023095-4dannjjm 2209 7 to to TO cord-023095-4dannjjm 2209 8 evaluate evaluate VB cord-023095-4dannjjm 2209 9 the the DT cord-023095-4dannjjm 2209 10 cross cross NN cord-023095-4dannjjm 2209 11 - - NN cord-023095-4dannjjm 2209 12 reactivity reactivity NN cord-023095-4dannjjm 2209 13 of of IN cord-023095-4dannjjm 2209 14 feline feline JJ cord-023095-4dannjjm 2209 15 insulin insulin NN cord-023095-4dannjjm 2209 16 with with IN cord-023095-4dannjjm 2209 17 a a DT cord-023095-4dannjjm 2209 18 commerciallyavailable commerciallyavailable JJ cord-023095-4dannjjm 2209 19 human human JJ cord-023095-4dannjjm 2209 20 insulin insulin NN cord-023095-4dannjjm 2209 21 ELISA ELISA NNP cord-023095-4dannjjm 2209 22 with with IN cord-023095-4dannjjm 2209 23 known know VBN cord-023095-4dannjjm 2209 24 cross cross NN cord-023095-4dannjjm 2209 25 reactivity reactivity NN cord-023095-4dannjjm 2209 26 to to IN cord-023095-4dannjjm 2209 27 several several JJ cord-023095-4dannjjm 2209 28 synthetic synthetic JJ cord-023095-4dannjjm 2209 29 analogs analog NNS cord-023095-4dannjjm 2209 30 . . . cord-023095-4dannjjm 2210 1 Pre pre JJ cord-023095-4dannjjm 2210 2 - - JJ cord-023095-4dannjjm 2210 3 and and CC cord-023095-4dannjjm 2210 4 post post JJ cord-023095-4dannjjm 2210 5 - - JJ cord-023095-4dannjjm 2210 6 prandial prandial JJ cord-023095-4dannjjm 2210 7 blood blood NN cord-023095-4dannjjm 2210 8 samples sample NNS cord-023095-4dannjjm 2210 9 were be VBD cord-023095-4dannjjm 2210 10 collected collect VBN cord-023095-4dannjjm 2210 11 from from IN cord-023095-4dannjjm 2210 12 four four CD cord-023095-4dannjjm 2210 13 healthy healthy JJ cord-023095-4dannjjm 2210 14 cats cat NNS cord-023095-4dannjjm 2210 15 immediately immediately RB cord-023095-4dannjjm 2210 16 prior prior RB cord-023095-4dannjjm 2210 17 to to IN cord-023095-4dannjjm 2210 18 and and CC cord-023095-4dannjjm 2210 19 approximately approximately RB cord-023095-4dannjjm 2210 20 15 15 CD cord-023095-4dannjjm 2210 21 minutes minute NNS cord-023095-4dannjjm 2210 22 following follow VBG cord-023095-4dannjjm 2210 23 a a DT cord-023095-4dannjjm 2210 24 meal meal NN cord-023095-4dannjjm 2210 25 , , , cord-023095-4dannjjm 2210 26 for for IN cord-023095-4dannjjm 2210 27 a a DT cord-023095-4dannjjm 2210 28 total total NN cord-023095-4dannjjm 2210 29 of of IN cord-023095-4dannjjm 2210 30 8 8 CD cord-023095-4dannjjm 2210 31 samples sample NNS cord-023095-4dannjjm 2210 32 . . . cord-023095-4dannjjm 2211 1 Dextrose dextrose NN cord-023095-4dannjjm 2211 2 was be VBD cord-023095-4dannjjm 2211 3 added add VBN cord-023095-4dannjjm 2211 4 to to IN cord-023095-4dannjjm 2211 5 the the DT cord-023095-4dannjjm 2211 6 meals meal NNS cord-023095-4dannjjm 2211 7 given give VBN cord-023095-4dannjjm 2211 8 to to IN cord-023095-4dannjjm 2211 9 two two CD cord-023095-4dannjjm 2211 10 of of IN cord-023095-4dannjjm 2211 11 the the DT cord-023095-4dannjjm 2211 12 cats cat NNS cord-023095-4dannjjm 2211 13 . . . cord-023095-4dannjjm 2212 1 Blood blood NN cord-023095-4dannjjm 2212 2 samples sample NNS cord-023095-4dannjjm 2212 3 were be VBD cord-023095-4dannjjm 2212 4 immediately immediately RB cord-023095-4dannjjm 2212 5 centrifuged centrifuge VBN cord-023095-4dannjjm 2212 6 and and CC cord-023095-4dannjjm 2212 7 the the DT cord-023095-4dannjjm 2212 8 serum serum NN cord-023095-4dannjjm 2212 9 was be VBD cord-023095-4dannjjm 2212 10 collected collect VBN cord-023095-4dannjjm 2212 11 , , , cord-023095-4dannjjm 2212 12 aliquoted aliquote VBN cord-023095-4dannjjm 2212 13 , , , cord-023095-4dannjjm 2212 14 and and CC cord-023095-4dannjjm 2212 15 stored store VBN cord-023095-4dannjjm 2212 16 at at IN cord-023095-4dannjjm 2212 17 À201C À201C NNPS cord-023095-4dannjjm 2212 18 until until IN cord-023095-4dannjjm 2212 19 analysis analysis NN cord-023095-4dannjjm 2212 20 . . . cord-023095-4dannjjm 2213 1 Serum serum NN cord-023095-4dannjjm 2213 2 insulin insulin NN cord-023095-4dannjjm 2213 3 levels level NNS cord-023095-4dannjjm 2213 4 were be VBD cord-023095-4dannjjm 2213 5 determined determine VBN cord-023095-4dannjjm 2213 6 in in IN cord-023095-4dannjjm 2213 7 parallel parallel NN cord-023095-4dannjjm 2213 8 with with IN cord-023095-4dannjjm 2213 9 commercially commercially RB cord-023095-4dannjjm 2213 10 - - HYPH cord-023095-4dannjjm 2213 11 available available JJ cord-023095-4dannjjm 2213 12 feline feline JJ cord-023095-4dannjjm 2213 13 insulin insulin NN cord-023095-4dannjjm 2213 14 and and CC cord-023095-4dannjjm 2213 15 human human JJ cord-023095-4dannjjm 2213 16 insulin insulin NN cord-023095-4dannjjm 2213 17 ELISAs elisa NNS cord-023095-4dannjjm 2213 18 . . . cord-023095-4dannjjm 2214 1 The the DT cord-023095-4dannjjm 2214 2 ELISAs elisa NNS cord-023095-4dannjjm 2214 3 were be VBD cord-023095-4dannjjm 2214 4 run run VBN cord-023095-4dannjjm 2214 5 in in IN cord-023095-4dannjjm 2214 6 duplicate duplicate NN cord-023095-4dannjjm 2214 7 and and CC cord-023095-4dannjjm 2214 8 according accord VBG cord-023095-4dannjjm 2214 9 to to IN cord-023095-4dannjjm 2214 10 the the DT cord-023095-4dannjjm 2214 11 manufacturer manufacturer NN cord-023095-4dannjjm 2214 12 's 's POS cord-023095-4dannjjm 2214 13 instructions instruction NNS cord-023095-4dannjjm 2214 14 . . . cord-023095-4dannjjm 2215 1 Concentrations concentration NNS cord-023095-4dannjjm 2215 2 of of IN cord-023095-4dannjjm 2215 3 serum serum NN cord-023095-4dannjjm 2215 4 insulin insulin NN cord-023095-4dannjjm 2215 5 measured measure VBN cord-023095-4dannjjm 2215 6 by by IN cord-023095-4dannjjm 2215 7 the the DT cord-023095-4dannjjm 2215 8 feline feline JJ cord-023095-4dannjjm 2215 9 insulin insulin NN cord-023095-4dannjjm 2215 10 ELISA ELISA NNP cord-023095-4dannjjm 2215 11 ranged range VBD cord-023095-4dannjjm 2215 12 from from IN cord-023095-4dannjjm 2215 13 12.7 12.7 CD cord-023095-4dannjjm 2215 14 ng ng NNP cord-023095-4dannjjm 2215 15 / / SYM cord-023095-4dannjjm 2215 16 L L NNP cord-023095-4dannjjm 2215 17 to to IN cord-023095-4dannjjm 2215 18 4 4 CD cord-023095-4dannjjm 2215 19 700 700 CD cord-023095-4dannjjm 2215 20 ng ng NNP cord-023095-4dannjjm 2215 21 / / SYM cord-023095-4dannjjm 2215 22 L. L. NNP cord-023095-4dannjjm 2216 1 Despite despite IN cord-023095-4dannjjm 2216 2 the the DT cord-023095-4dannjjm 2216 3 wide wide JJ cord-023095-4dannjjm 2216 4 range range NN cord-023095-4dannjjm 2216 5 of of IN cord-023095-4dannjjm 2216 6 concentrations concentration NNS cord-023095-4dannjjm 2216 7 of of IN cord-023095-4dannjjm 2216 8 feline feline JJ cord-023095-4dannjjm 2216 9 insulin insulin NN cord-023095-4dannjjm 2216 10 , , , cord-023095-4dannjjm 2216 11 all all DT cord-023095-4dannjjm 2216 12 8 8 CD cord-023095-4dannjjm 2216 13 samples sample NNS cord-023095-4dannjjm 2216 14 evaluated evaluate VBN cord-023095-4dannjjm 2216 15 with with IN cord-023095-4dannjjm 2216 16 the the DT cord-023095-4dannjjm 2216 17 human human JJ cord-023095-4dannjjm 2216 18 insulin insulin NN cord-023095-4dannjjm 2216 19 ELISA ELISA NNP cord-023095-4dannjjm 2216 20 yielded yield VBD cord-023095-4dannjjm 2216 21 absorbance absorbance NN cord-023095-4dannjjm 2216 22 readings reading NNS cord-023095-4dannjjm 2216 23 equal equal JJ cord-023095-4dannjjm 2216 24 to to IN cord-023095-4dannjjm 2216 25 or or CC cord-023095-4dannjjm 2216 26 lower low JJR cord-023095-4dannjjm 2216 27 than than IN cord-023095-4dannjjm 2216 28 the the DT cord-023095-4dannjjm 2216 29 absorbance absorbance NN cord-023095-4dannjjm 2216 30 of of IN cord-023095-4dannjjm 2216 31 the the DT cord-023095-4dannjjm 2216 32 negative negative JJ cord-023095-4dannjjm 2216 33 control control NN cord-023095-4dannjjm 2216 34 , , , cord-023095-4dannjjm 2216 35 indicating indicate VBG cord-023095-4dannjjm 2216 36 no no DT cord-023095-4dannjjm 2216 37 crossreactivity crossreactivity NN cord-023095-4dannjjm 2216 38 between between IN cord-023095-4dannjjm 2216 39 the the DT cord-023095-4dannjjm 2216 40 evaluated evaluate VBN cord-023095-4dannjjm 2216 41 human human JJ cord-023095-4dannjjm 2216 42 insulin insulin NN cord-023095-4dannjjm 2216 43 assay assay NN cord-023095-4dannjjm 2216 44 and and CC cord-023095-4dannjjm 2216 45 feline feline JJ cord-023095-4dannjjm 2216 46 insulin insulin NN cord-023095-4dannjjm 2216 47 . . . cord-023095-4dannjjm 2217 1 Since since IN cord-023095-4dannjjm 2217 2 this this DT cord-023095-4dannjjm 2217 3 assay assay NN cord-023095-4dannjjm 2217 4 is be VBZ cord-023095-4dannjjm 2217 5 reported report VBN cord-023095-4dannjjm 2217 6 to to TO cord-023095-4dannjjm 2217 7 cross cross VB cord-023095-4dannjjm 2217 8 - - VB cord-023095-4dannjjm 2217 9 react react VB cord-023095-4dannjjm 2217 10 significantly significantly RB cord-023095-4dannjjm 2217 11 with with IN cord-023095-4dannjjm 2217 12 glargine glargine NNP cord-023095-4dannjjm 2217 13 , , , cord-023095-4dannjjm 2217 14 it -PRON- PRP cord-023095-4dannjjm 2217 15 is be VBZ cord-023095-4dannjjm 2217 16 a a DT cord-023095-4dannjjm 2217 17 great great JJ cord-023095-4dannjjm 2217 18 candidate candidate NN cord-023095-4dannjjm 2217 19 for for IN cord-023095-4dannjjm 2217 20 determination determination NN cord-023095-4dannjjm 2217 21 of of IN cord-023095-4dannjjm 2217 22 serum serum NN cord-023095-4dannjjm 2217 23 glargine glargine JJ cord-023095-4dannjjm 2217 24 concentrations concentration NNS cord-023095-4dannjjm 2217 25 in in IN cord-023095-4dannjjm 2217 26 cats cat NNS cord-023095-4dannjjm 2217 27 . . . cord-023095-4dannjjm 2218 1 The the DT cord-023095-4dannjjm 2218 2 aim aim NN cord-023095-4dannjjm 2218 3 of of IN cord-023095-4dannjjm 2218 4 this this DT cord-023095-4dannjjm 2218 5 prospective prospective NN cord-023095-4dannjjm 2218 6 , , , cord-023095-4dannjjm 2218 7 controlled controlled JJ cord-023095-4dannjjm 2218 8 study study NN cord-023095-4dannjjm 2218 9 was be VBD cord-023095-4dannjjm 2218 10 to to TO cord-023095-4dannjjm 2218 11 compare compare VB cord-023095-4dannjjm 2218 12 the the DT cord-023095-4dannjjm 2218 13 efficacy efficacy NN cord-023095-4dannjjm 2218 14 of of IN cord-023095-4dannjjm 2218 15 two two CD cord-023095-4dannjjm 2218 16 trilostane trilostane NNP cord-023095-4dannjjm 2218 17 protocols protocol NNS cord-023095-4dannjjm 2218 18 for for IN cord-023095-4dannjjm 2218 19 treatment treatment NN cord-023095-4dannjjm 2218 20 of of IN cord-023095-4dannjjm 2218 21 canine canine JJ cord-023095-4dannjjm 2218 22 pituitary pituitary NN cord-023095-4dannjjm 2218 23 - - HYPH cord-023095-4dannjjm 2218 24 dependent dependent JJ cord-023095-4dannjjm 2218 25 hyperadrenocorticism hyperadrenocorticism NN cord-023095-4dannjjm 2218 26 ( ( -LRB- cord-023095-4dannjjm 2218 27 PDH PDH NNP cord-023095-4dannjjm 2218 28 ) ) -RRB- cord-023095-4dannjjm 2218 29 . . . cord-023095-4dannjjm 2219 1 Among among IN cord-023095-4dannjjm 2219 2 the the DT cord-023095-4dannjjm 2219 3 28 28 CD cord-023095-4dannjjm 2219 4 client client NN cord-023095-4dannjjm 2219 5 - - HYPH cord-023095-4dannjjm 2219 6 owned own VBN cord-023095-4dannjjm 2219 7 dogs dog NNS cord-023095-4dannjjm 2219 8 diagnosed diagnose VBN cord-023095-4dannjjm 2219 9 with with IN cord-023095-4dannjjm 2219 10 PDH PDH NNP cord-023095-4dannjjm 2219 11 , , , cord-023095-4dannjjm 2219 12 only only RB cord-023095-4dannjjm 2219 13 the the DT cord-023095-4dannjjm 2219 14 dogs dog NNS cord-023095-4dannjjm 2219 15 weighing weigh VBG cord-023095-4dannjjm 2219 16 o o NN cord-023095-4dannjjm 2219 17 5 5 CD cord-023095-4dannjjm 2219 18 kg kg NNS cord-023095-4dannjjm 2219 19 were be VBD cord-023095-4dannjjm 2219 20 selected select VBN cord-023095-4dannjjm 2219 21 ( ( -LRB- cord-023095-4dannjjm 2219 22 n n NN cord-023095-4dannjjm 2219 23 5 5 CD cord-023095-4dannjjm 2219 24 16 16 CD cord-023095-4dannjjm 2219 25 ) ) -RRB- cord-023095-4dannjjm 2219 26 . . . cord-023095-4dannjjm 2220 1 Group Group NNP cord-023095-4dannjjm 2220 2 A A NNP cord-023095-4dannjjm 2220 3 ( ( -LRB- cord-023095-4dannjjm 2220 4 n n NN cord-023095-4dannjjm 2220 5 5 5 CD cord-023095-4dannjjm 2220 6 9 9 CD cord-023095-4dannjjm 2220 7 ; ; : cord-023095-4dannjjm 2220 8 low low JJ cord-023095-4dannjjm 2220 9 - - HYPH cord-023095-4dannjjm 2220 10 dose dose NN cord-023095-4dannjjm 2220 11 treatment treatment NN cord-023095-4dannjjm 2220 12 group group NN cord-023095-4dannjjm 2220 13 ) ) -RRB- cord-023095-4dannjjm 2220 14 and and CC cord-023095-4dannjjm 2220 15 group group NN cord-023095-4dannjjm 2220 16 B B NNP cord-023095-4dannjjm 2220 17 ( ( -LRB- cord-023095-4dannjjm 2220 18 n n NN cord-023095-4dannjjm 2220 19 5 5 CD cord-023095-4dannjjm 2220 20 7 7 CD cord-023095-4dannjjm 2220 21 ; ; : cord-023095-4dannjjm 2220 22 high high JJ cord-023095-4dannjjm 2220 23 - - HYPH cord-023095-4dannjjm 2220 24 dose dose NN cord-023095-4dannjjm 2220 25 treatment treatment NN cord-023095-4dannjjm 2220 26 group group NN cord-023095-4dannjjm 2220 27 ) ) -RRB- cord-023095-4dannjjm 2220 28 received receive VBD cord-023095-4dannjjm 2220 29 0.8 0.8 CD cord-023095-4dannjjm 2220 30 AE AE NNP cord-023095-4dannjjm 2220 31 0.3 0.3 CD cord-023095-4dannjjm 2220 32 mg mg NN cord-023095-4dannjjm 2220 33 of of IN cord-023095-4dannjjm 2220 34 trilostane trilostane NNP cord-023095-4dannjjm 2220 35 / / SYM cord-023095-4dannjjm 2220 36 kg kg VBZ cord-023095-4dannjjm 2220 37 orally orally RB cord-023095-4dannjjm 2220 38 every every DT cord-023095-4dannjjm 2220 39 12 12 CD cord-023095-4dannjjm 2220 40 hours hour NNS cord-023095-4dannjjm 2220 41 and and CC cord-023095-4dannjjm 2220 42 30 30 CD cord-023095-4dannjjm 2220 43 mg mg NN cord-023095-4dannjjm 2220 44 of of IN cord-023095-4dannjjm 2220 45 trilostane/ trilostane/ CD cord-023095-4dannjjm 2220 46 body body NN cord-023095-4dannjjm 2220 47 orally orally RB cord-023095-4dannjjm 2220 48 every every DT cord-023095-4dannjjm 2220 49 24 24 CD cord-023095-4dannjjm 2220 50 hours hour NNS cord-023095-4dannjjm 2220 51 , , , cord-023095-4dannjjm 2220 52 respectively respectively RB cord-023095-4dannjjm 2220 53 . . . cord-023095-4dannjjm 2221 1 All all DT cord-023095-4dannjjm 2221 2 of of IN cord-023095-4dannjjm 2221 3 the the DT cord-023095-4dannjjm 2221 4 dogs dog NNS cord-023095-4dannjjm 2221 5 were be VBD cord-023095-4dannjjm 2221 6 reassessed reassess VBN cord-023095-4dannjjm 2221 7 at at IN cord-023095-4dannjjm 2221 8 2 2 CD cord-023095-4dannjjm 2221 9 , , , cord-023095-4dannjjm 2221 10 4 4 CD cord-023095-4dannjjm 2221 11 , , , cord-023095-4dannjjm 2221 12 12 12 CD cord-023095-4dannjjm 2221 13 , , , cord-023095-4dannjjm 2221 14 and and CC cord-023095-4dannjjm 2221 15 24 24 CD cord-023095-4dannjjm 2221 16 weeks week NNS cord-023095-4dannjjm 2221 17 after after IN cord-023095-4dannjjm 2221 18 the the DT cord-023095-4dannjjm 2221 19 initiation initiation NN cord-023095-4dannjjm 2221 20 of of IN cord-023095-4dannjjm 2221 21 treatment treatment NN cord-023095-4dannjjm 2221 22 . . . cord-023095-4dannjjm 2222 1 The the DT cord-023095-4dannjjm 2222 2 improvement improvement NN cord-023095-4dannjjm 2222 3 in in IN cord-023095-4dannjjm 2222 4 post post JJ cord-023095-4dannjjm 2222 5 - - JJ cord-023095-4dannjjm 2222 6 ACTH acth JJ cord-023095-4dannjjm 2222 7 stimulation stimulation NN cord-023095-4dannjjm 2222 8 serum serum NN cord-023095-4dannjjm 2222 9 cortisol cortisol NN cord-023095-4dannjjm 2222 10 concentration concentration NN cord-023095-4dannjjm 2222 11 , , , cord-023095-4dannjjm 2222 12 as as RB cord-023095-4dannjjm 2222 13 well well RB cord-023095-4dannjjm 2222 14 as as IN cord-023095-4dannjjm 2222 15 clinical clinical JJ cord-023095-4dannjjm 2222 16 signs sign NNS cord-023095-4dannjjm 2222 17 in in IN cord-023095-4dannjjm 2222 18 group group NN cord-023095-4dannjjm 2222 19 A A NNP cord-023095-4dannjjm 2222 20 , , , cord-023095-4dannjjm 2222 21 required require VBN cord-023095-4dannjjm 2222 22 more more JJR cord-023095-4dannjjm 2222 23 time time NN cord-023095-4dannjjm 2222 24 than than IN cord-023095-4dannjjm 2222 25 group group NN cord-023095-4dannjjm 2222 26 B b NN cord-023095-4dannjjm 2222 27 ; ; : cord-023095-4dannjjm 2222 28 however however RB cord-023095-4dannjjm 2222 29 , , , cord-023095-4dannjjm 2222 30 2 2 CD cord-023095-4dannjjm 2222 31 of of IN cord-023095-4dannjjm 2222 32 7 7 CD cord-023095-4dannjjm 2222 33 dogs dog NNS cord-023095-4dannjjm 2222 34 in in IN cord-023095-4dannjjm 2222 35 group group NN cord-023095-4dannjjm 2222 36 B B NNP cord-023095-4dannjjm 2222 37 had have VBD cord-023095-4dannjjm 2222 38 clinical clinical JJ cord-023095-4dannjjm 2222 39 signs sign NNS cord-023095-4dannjjm 2222 40 and and CC cord-023095-4dannjjm 2222 41 abnormal abnormal JJ cord-023095-4dannjjm 2222 42 laboratory laboratory NN cord-023095-4dannjjm 2222 43 findings finding NNS cord-023095-4dannjjm 2222 44 consistent consistent JJ cord-023095-4dannjjm 2222 45 with with IN cord-023095-4dannjjm 2222 46 hypoadrenocorticism hypoadrenocorticism NN cord-023095-4dannjjm 2222 47 after after IN cord-023095-4dannjjm 2222 48 treatment treatment NN cord-023095-4dannjjm 2222 49 for for IN cord-023095-4dannjjm 2222 50 20 20 CD cord-023095-4dannjjm 2222 51 weeks week NNS cord-023095-4dannjjm 2222 52 . . . cord-023095-4dannjjm 2223 1 Twenty twenty CD cord-023095-4dannjjm 2223 2 - - HYPH cord-023095-4dannjjm 2223 3 four four CD cord-023095-4dannjjm 2223 4 weeks week NNS cord-023095-4dannjjm 2223 5 later later RB cord-023095-4dannjjm 2223 6 , , , cord-023095-4dannjjm 2223 7 all all DT cord-023095-4dannjjm 2223 8 of of IN cord-023095-4dannjjm 2223 9 the the DT cord-023095-4dannjjm 2223 10 dogs dog NNS cord-023095-4dannjjm 2223 11 of of IN cord-023095-4dannjjm 2223 12 both both DT cord-023095-4dannjjm 2223 13 groups group NNS cord-023095-4dannjjm 2223 14 improved improve VBD cord-023095-4dannjjm 2223 15 the the DT cord-023095-4dannjjm 2223 16 abnormal abnormal JJ cord-023095-4dannjjm 2223 17 clinical clinical JJ cord-023095-4dannjjm 2223 18 findings finding NNS cord-023095-4dannjjm 2223 19 . . . cord-023095-4dannjjm 2224 1 The the DT cord-023095-4dannjjm 2224 2 present present JJ cord-023095-4dannjjm 2224 3 study study NN cord-023095-4dannjjm 2224 4 suggests suggest VBZ cord-023095-4dannjjm 2224 5 that that IN cord-023095-4dannjjm 2224 6 twice twice RB cord-023095-4dannjjm 2224 7 daily daily JJ cord-023095-4dannjjm 2224 8 , , , cord-023095-4dannjjm 2224 9 low low JJ cord-023095-4dannjjm 2224 10 - - HYPH cord-023095-4dannjjm 2224 11 dose dose NN cord-023095-4dannjjm 2224 12 administration administration NN cord-023095-4dannjjm 2224 13 of of IN cord-023095-4dannjjm 2224 14 trilostane trilostane NNP cord-023095-4dannjjm 2224 15 is be VBZ cord-023095-4dannjjm 2224 16 effective effective JJ cord-023095-4dannjjm 2224 17 in in IN cord-023095-4dannjjm 2224 18 the the DT cord-023095-4dannjjm 2224 19 management management NN cord-023095-4dannjjm 2224 20 of of IN cord-023095-4dannjjm 2224 21 canine canine JJ cord-023095-4dannjjm 2224 22 PDH PDH NNP cord-023095-4dannjjm 2224 23 and and CC cord-023095-4dannjjm 2224 24 may may MD cord-023095-4dannjjm 2224 25 be be VB cord-023095-4dannjjm 2224 26 safe safe JJ cord-023095-4dannjjm 2224 27 without without IN cord-023095-4dannjjm 2224 28 the the DT cord-023095-4dannjjm 2224 29 potential potential JJ cord-023095-4dannjjm 2224 30 adverse adverse JJ cord-023095-4dannjjm 2224 31 effects effect NNS cord-023095-4dannjjm 2224 32 of of IN cord-023095-4dannjjm 2224 33 once once RB cord-023095-4dannjjm 2224 34 daily daily JJ cord-023095-4dannjjm 2224 35 , , , cord-023095-4dannjjm 2224 36 high high JJ cord-023095-4dannjjm 2224 37 - - HYPH cord-023095-4dannjjm 2224 38 dose dose NN cord-023095-4dannjjm 2224 39 treatment treatment NN cord-023095-4dannjjm 2224 40 . . . cord-023095-4dannjjm 2225 1 However however RB cord-023095-4dannjjm 2225 2 , , , cord-023095-4dannjjm 2225 3 because because IN cord-023095-4dannjjm 2225 4 this this DT cord-023095-4dannjjm 2225 5 study study NN cord-023095-4dannjjm 2225 6 involved involve VBN cord-023095-4dannjjm 2225 7 only only RB cord-023095-4dannjjm 2225 8 a a DT cord-023095-4dannjjm 2225 9 small small JJ cord-023095-4dannjjm 2225 10 number number NN cord-023095-4dannjjm 2225 11 of of IN cord-023095-4dannjjm 2225 12 dogs dog NNS cord-023095-4dannjjm 2225 13 , , , cord-023095-4dannjjm 2225 14 a a DT cord-023095-4dannjjm 2225 15 population population NN cord-023095-4dannjjm 2225 16 - - HYPH cord-023095-4dannjjm 2225 17 based base VBN cord-023095-4dannjjm 2225 18 control control NN cord-023095-4dannjjm 2225 19 study study NN cord-023095-4dannjjm 2225 20 will will MD cord-023095-4dannjjm 2225 21 be be VB cord-023095-4dannjjm 2225 22 needed need VBN cord-023095-4dannjjm 2225 23 to to TO cord-023095-4dannjjm 2225 24 clarify clarify VB cord-023095-4dannjjm 2225 25 the the DT cord-023095-4dannjjm 2225 26 efficacy efficacy NN cord-023095-4dannjjm 2225 27 of of IN cord-023095-4dannjjm 2225 28 low low RB cord-023095-4dannjjm 2225 29 - - HYPH cord-023095-4dannjjm 2225 30 compared compare VBN cord-023095-4dannjjm 2225 31 to to IN cord-023095-4dannjjm 2225 32 high high JJ cord-023095-4dannjjm 2225 33 - - HYPH cord-023095-4dannjjm 2225 34 dose dose NN cord-023095-4dannjjm 2225 35 trilostane trilostane NNP cord-023095-4dannjjm 2225 36 treatment treatment NN cord-023095-4dannjjm 2225 37 . . . cord-023095-4dannjjm 2226 1 Cobalamin Cobalamin NNP cord-023095-4dannjjm 2226 2 is be VBZ cord-023095-4dannjjm 2226 3 essential essential JJ cord-023095-4dannjjm 2226 4 for for IN cord-023095-4dannjjm 2226 5 a a DT cord-023095-4dannjjm 2226 6 variety variety NN cord-023095-4dannjjm 2226 7 of of IN cord-023095-4dannjjm 2226 8 metabolic metabolic JJ cord-023095-4dannjjm 2226 9 processes process NNS cord-023095-4dannjjm 2226 10 in in IN cord-023095-4dannjjm 2226 11 many many JJ cord-023095-4dannjjm 2226 12 tissues tissue NNS cord-023095-4dannjjm 2226 13 and and CC cord-023095-4dannjjm 2226 14 organs organ NNS cord-023095-4dannjjm 2226 15 , , , cord-023095-4dannjjm 2226 16 and and CC cord-023095-4dannjjm 2226 17 has have VBZ cord-023095-4dannjjm 2226 18 effects effect NNS cord-023095-4dannjjm 2226 19 on on IN cord-023095-4dannjjm 2226 20 cell cell NN cord-023095-4dannjjm 2226 21 growth growth NN cord-023095-4dannjjm 2226 22 and and CC cord-023095-4dannjjm 2226 23 peripheral peripheral JJ cord-023095-4dannjjm 2226 24 and and CC cord-023095-4dannjjm 2226 25 central central JJ cord-023095-4dannjjm 2226 26 nervous nervous JJ cord-023095-4dannjjm 2226 27 system system NN cord-023095-4dannjjm 2226 28 function function NN cord-023095-4dannjjm 2226 29 . . . cord-023095-4dannjjm 2227 1 Chronic chronic JJ cord-023095-4dannjjm 2227 2 distal distal JJ cord-023095-4dannjjm 2227 3 small small JJ cord-023095-4dannjjm 2227 4 intestinal intestinal JJ cord-023095-4dannjjm 2227 5 disease disease NN cord-023095-4dannjjm 2227 6 in in IN cord-023095-4dannjjm 2227 7 humans human NNS cord-023095-4dannjjm 2227 8 , , , cord-023095-4dannjjm 2227 9 cats cat NNS cord-023095-4dannjjm 2227 10 , , , cord-023095-4dannjjm 2227 11 and and CC cord-023095-4dannjjm 2227 12 dogs dog NNS cord-023095-4dannjjm 2227 13 has have VBZ cord-023095-4dannjjm 2227 14 been be VBN cord-023095-4dannjjm 2227 15 shown show VBN cord-023095-4dannjjm 2227 16 to to TO cord-023095-4dannjjm 2227 17 cause cause VB cord-023095-4dannjjm 2227 18 cobalamin cobalamin JJ cord-023095-4dannjjm 2227 19 deficiency deficiency NN cord-023095-4dannjjm 2227 20 . . . cord-023095-4dannjjm 2228 1 An an DT cord-023095-4dannjjm 2228 2 immunoassay immunoassay NN cord-023095-4dannjjm 2228 3 for for IN cord-023095-4dannjjm 2228 4 the the DT cord-023095-4dannjjm 2228 5 measurement measurement NN cord-023095-4dannjjm 2228 6 of of IN cord-023095-4dannjjm 2228 7 serum serum NN cord-023095-4dannjjm 2228 8 cobalamin cobalamin NN cord-023095-4dannjjm 2228 9 concentration concentration NN cord-023095-4dannjjm 2228 10 in in IN cord-023095-4dannjjm 2228 11 these these DT cord-023095-4dannjjm 2228 12 species specie NNS cord-023095-4dannjjm 2228 13 is be VBZ cord-023095-4dannjjm 2228 14 being be VBG cord-023095-4dannjjm 2228 15 used use VBN cord-023095-4dannjjm 2228 16 in in IN cord-023095-4dannjjm 2228 17 routine routine JJ cord-023095-4dannjjm 2228 18 practice practice NN cord-023095-4dannjjm 2228 19 for for IN cord-023095-4dannjjm 2228 20 the the DT cord-023095-4dannjjm 2228 21 diagnosis diagnosis NN cord-023095-4dannjjm 2228 22 of of IN cord-023095-4dannjjm 2228 23 cobalamin cobalamin NN cord-023095-4dannjjm 2228 24 deficiency deficiency NN cord-023095-4dannjjm 2228 25 . . . cord-023095-4dannjjm 2229 1 In in IN cord-023095-4dannjjm 2229 2 pigs pig NNS cord-023095-4dannjjm 2229 3 , , , cord-023095-4dannjjm 2229 4 the the DT cord-023095-4dannjjm 2229 5 role role NN cord-023095-4dannjjm 2229 6 of of IN cord-023095-4dannjjm 2229 7 cobalamin cobalamin NN cord-023095-4dannjjm 2229 8 has have VBZ cord-023095-4dannjjm 2229 9 not not RB cord-023095-4dannjjm 2229 10 yet yet RB cord-023095-4dannjjm 2229 11 been be VBN cord-023095-4dannjjm 2229 12 extensively extensively RB cord-023095-4dannjjm 2229 13 investigated investigate VBN cord-023095-4dannjjm 2229 14 . . . cord-023095-4dannjjm 2230 1 Thus thus RB cord-023095-4dannjjm 2230 2 , , , cord-023095-4dannjjm 2230 3 the the DT cord-023095-4dannjjm 2230 4 aim aim NN cord-023095-4dannjjm 2230 5 of of IN cord-023095-4dannjjm 2230 6 this this DT cord-023095-4dannjjm 2230 7 study study NN cord-023095-4dannjjm 2230 8 was be VBD cord-023095-4dannjjm 2230 9 to to TO cord-023095-4dannjjm 2230 10 analytically analytically RB cord-023095-4dannjjm 2230 11 validate validate VB cord-023095-4dannjjm 2230 12 an an DT cord-023095-4dannjjm 2230 13 immunoassay immunoassay NN cord-023095-4dannjjm 2230 14 , , , cord-023095-4dannjjm 2230 15 labeled label VBN cord-023095-4dannjjm 2230 16 for for IN cord-023095-4dannjjm 2230 17 use use NN cord-023095-4dannjjm 2230 18 in in IN cord-023095-4dannjjm 2230 19 humans human NNS cord-023095-4dannjjm 2230 20 , , , cord-023095-4dannjjm 2230 21 for for IN cord-023095-4dannjjm 2230 22 the the DT cord-023095-4dannjjm 2230 23 measurement measurement NN cord-023095-4dannjjm 2230 24 of of IN cord-023095-4dannjjm 2230 25 cobalamin cobalamin NN cord-023095-4dannjjm 2230 26 in in IN cord-023095-4dannjjm 2230 27 porcine porcine JJ cord-023095-4dannjjm 2230 28 serum serum NN cord-023095-4dannjjm 2230 29 samples sample NNS cord-023095-4dannjjm 2230 30 and and CC cord-023095-4dannjjm 2230 31 secondly secondly RB cord-023095-4dannjjm 2230 32 to to TO cord-023095-4dannjjm 2230 33 determine determine VB cord-023095-4dannjjm 2230 34 serum serum NN cord-023095-4dannjjm 2230 35 cobalamin cobalamin NN cord-023095-4dannjjm 2230 36 concentrations concentration NNS cord-023095-4dannjjm 2230 37 in in IN cord-023095-4dannjjm 2230 38 weaned wean VBN cord-023095-4dannjjm 2230 39 pigs pig NNS cord-023095-4dannjjm 2230 40 . . . cord-023095-4dannjjm 2231 1 For for IN cord-023095-4dannjjm 2231 2 the the DT cord-023095-4dannjjm 2231 3 analytical analytical JJ cord-023095-4dannjjm 2231 4 validation validation NN cord-023095-4dannjjm 2231 5 of of IN cord-023095-4dannjjm 2231 6 the the DT cord-023095-4dannjjm 2231 7 assay assay NN cord-023095-4dannjjm 2231 8 , , , cord-023095-4dannjjm 2231 9 serum serum NN cord-023095-4dannjjm 2231 10 cobalamin cobalamin NN cord-023095-4dannjjm 2231 11 concentrations concentration NNS cord-023095-4dannjjm 2231 12 were be VBD cord-023095-4dannjjm 2231 13 measured measure VBN cord-023095-4dannjjm 2231 14 using use VBG cord-023095-4dannjjm 2231 15 the the DT cord-023095-4dannjjm 2231 16 commercially commercially RB cord-023095-4dannjjm 2231 17 available available JJ cord-023095-4dannjjm 2231 18 IMMULITE IMMULITE NNP cord-023095-4dannjjm 2231 19 s s NN cord-023095-4dannjjm 2231 20 2000 2000 CD cord-023095-4dannjjm 2231 21 cobalamin cobalamin NN cord-023095-4dannjjm 2231 22 immunoassay immunoassay NN cord-023095-4dannjjm 2231 23 ( ( -LRB- cord-023095-4dannjjm 2231 24 Siemens Siemens NNP cord-023095-4dannjjm 2231 25 Healthcare Healthcare NNP cord-023095-4dannjjm 2231 26 Diagnostics Diagnostics NNPS cord-023095-4dannjjm 2231 27 Ltd. Ltd. NNP cord-023095-4dannjjm 2231 28 , , , cord-023095-4dannjjm 2231 29 Deerfield Deerfield NNP cord-023095-4dannjjm 2231 30 , , , cord-023095-4dannjjm 2231 31 IL IL NNP cord-023095-4dannjjm 2231 32 , , , cord-023095-4dannjjm 2231 33 USA USA NNP cord-023095-4dannjjm 2231 34 ) ) -RRB- cord-023095-4dannjjm 2231 35 in in IN cord-023095-4dannjjm 2231 36 30 30 CD cord-023095-4dannjjm 2231 37 surplus surplus JJ cord-023095-4dannjjm 2231 38 porcine porcine JJ cord-023095-4dannjjm 2231 39 serum serum NN cord-023095-4dannjjm 2231 40 samples sample NNS cord-023095-4dannjjm 2231 41 from from IN cord-023095-4dannjjm 2231 42 a a DT cord-023095-4dannjjm 2231 43 variety variety NN cord-023095-4dannjjm 2231 44 of of IN cord-023095-4dannjjm 2231 45 studies study NNS cord-023095-4dannjjm 2231 46 . . . cord-023095-4dannjjm 2232 1 Validation validation NN cord-023095-4dannjjm 2232 2 of of IN cord-023095-4dannjjm 2232 3 the the DT cord-023095-4dannjjm 2232 4 assay assay NN cord-023095-4dannjjm 2232 5 consisted consist VBD cord-023095-4dannjjm 2232 6 of of IN cord-023095-4dannjjm 2232 7 determination determination NN cord-023095-4dannjjm 2232 8 of of IN cord-023095-4dannjjm 2232 9 dilutional dilutional JJ cord-023095-4dannjjm 2232 10 parallelism parallelism NN cord-023095-4dannjjm 2232 11 , , , cord-023095-4dannjjm 2232 12 spiking spike VBG cord-023095-4dannjjm 2232 13 recovery recovery NN cord-023095-4dannjjm 2232 14 , , , cord-023095-4dannjjm 2232 15 and and CC cord-023095-4dannjjm 2232 16 intra intra JJ cord-023095-4dannjjm 2232 17 - - : cord-023095-4dannjjm 2232 18 and and CC cord-023095-4dannjjm 2232 19 inter inter JJ cord-023095-4dannjjm 2232 20 - - JJ cord-023095-4dannjjm 2232 21 assay assay JJ cord-023095-4dannjjm 2232 22 variability variability NN cord-023095-4dannjjm 2232 23 . . . cord-023095-4dannjjm 2233 1 Additional additional JJ cord-023095-4dannjjm 2233 2 surplus surplus NN cord-023095-4dannjjm 2233 3 serum serum NN cord-023095-4dannjjm 2233 4 samples sample NNS cord-023095-4dannjjm 2233 5 from from IN cord-023095-4dannjjm 2233 6 27 27 CD cord-023095-4dannjjm 2233 7 piglets piglet NNS cord-023095-4dannjjm 2233 8 from from IN cord-023095-4dannjjm 2233 9 four four CD cord-023095-4dannjjm 2233 10 litters litter NNS cord-023095-4dannjjm 2233 11 at at IN cord-023095-4dannjjm 2233 12 a a DT cord-023095-4dannjjm 2233 13 Texas Texas NNP cord-023095-4dannjjm 2233 14 A&M A&M NNP cord-023095-4dannjjm 2233 15 University University NNP cord-023095-4dannjjm 2233 16 farm farm NN cord-023095-4dannjjm 2233 17 were be VBD cord-023095-4dannjjm 2233 18 obtained obtain VBN cord-023095-4dannjjm 2233 19 . . . cord-023095-4dannjjm 2234 1 Each each DT cord-023095-4dannjjm 2234 2 piglet piglet NN cord-023095-4dannjjm 2234 3 had have VBD cord-023095-4dannjjm 2234 4 been be VBN cord-023095-4dannjjm 2234 5 bled bleed VBN cord-023095-4dannjjm 2234 6 twice twice RB cord-023095-4dannjjm 2234 7 , , , cord-023095-4dannjjm 2234 8 the the DT cord-023095-4dannjjm 2234 9 first first JJ cord-023095-4dannjjm 2234 10 at at IN cord-023095-4dannjjm 2234 11 weaning wean VBG cord-023095-4dannjjm 2234 12 ( ( -LRB- cord-023095-4dannjjm 2234 13 21 21 CD cord-023095-4dannjjm 2234 14 days day NNS cord-023095-4dannjjm 2234 15 of of IN cord-023095-4dannjjm 2234 16 age age NN cord-023095-4dannjjm 2234 17 ) ) -RRB- cord-023095-4dannjjm 2234 18 and and CC cord-023095-4dannjjm 2234 19 the the DT cord-023095-4dannjjm 2234 20 second second JJ cord-023095-4dannjjm 2234 21 one one CD cord-023095-4dannjjm 2234 22 12 12 CD cord-023095-4dannjjm 2234 23 days day NNS cord-023095-4dannjjm 2234 24 later later RB cord-023095-4dannjjm 2234 25 . . . cord-023095-4dannjjm 2235 1 To to TO cord-023095-4dannjjm 2235 2 investigate investigate VB cord-023095-4dannjjm 2235 3 results result NNS cord-023095-4dannjjm 2235 4 in in IN cord-023095-4dannjjm 2235 5 comparison comparison NN cord-023095-4dannjjm 2235 6 between between IN cord-023095-4dannjjm 2235 7 age age NN cord-023095-4dannjjm 2235 8 groups group NNS cord-023095-4dannjjm 2235 9 , , , cord-023095-4dannjjm 2235 10 serum serum NN cord-023095-4dannjjm 2235 11 cobalamin cobalamin NN cord-023095-4dannjjm 2235 12 concentrations concentration NNS cord-023095-4dannjjm 2235 13 were be VBD cord-023095-4dannjjm 2235 14 compared compare VBN cord-023095-4dannjjm 2235 15 using use VBG cord-023095-4dannjjm 2235 16 a a DT cord-023095-4dannjjm 2235 17 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 2235 18 matched match VBN cord-023095-4dannjjm 2235 19 pairs pair NNS cord-023095-4dannjjm 2235 20 test test VBP cord-023095-4dannjjm 2235 21 . . . cord-023095-4dannjjm 2236 1 Significance significance NN cord-023095-4dannjjm 2236 2 was be VBD cord-023095-4dannjjm 2236 3 set set VBN cord-023095-4dannjjm 2236 4 at at IN cord-023095-4dannjjm 2236 5 p p NN cord-023095-4dannjjm 2236 6 o o NN cord-023095-4dannjjm 2236 7 0.05 0.05 CD cord-023095-4dannjjm 2236 8 . . . cord-023095-4dannjjm 2237 1 Observed observe VBN cord-023095-4dannjjm 2237 2 to to TO cord-023095-4dannjjm 2237 3 expected expect VBN cord-023095-4dannjjm 2237 4 ratios ratio NNS cord-023095-4dannjjm 2237 5 ( ( -LRB- cord-023095-4dannjjm 2237 6 O o UH cord-023095-4dannjjm 2237 7 / / SYM cord-023095-4dannjjm 2237 8 E e NN cord-023095-4dannjjm 2237 9 ) ) -RRB- cord-023095-4dannjjm 2237 10 for for IN cord-023095-4dannjjm 2237 11 serial serial JJ cord-023095-4dannjjm 2237 12 dilutions dilution NNS cord-023095-4dannjjm 2237 13 ranged range VBD cord-023095-4dannjjm 2237 14 from from IN cord-023095-4dannjjm 2237 15 87.3 87.3 CD cord-023095-4dannjjm 2237 16 to to IN cord-023095-4dannjjm 2237 17 124.9 124.9 CD cord-023095-4dannjjm 2237 18 % % NN cord-023095-4dannjjm 2237 19 ( ( -LRB- cord-023095-4dannjjm 2237 20 mean mean VB cord-023095-4dannjjm 2237 21 AE AE NNP cord-023095-4dannjjm 2237 22 SD SD NNP cord-023095-4dannjjm 2237 23 : : : cord-023095-4dannjjm 2237 24 104.2 104.2 CD cord-023095-4dannjjm 2237 25 AE AE NNP cord-023095-4dannjjm 2237 26 14.5 14.5 CD cord-023095-4dannjjm 2237 27 % % NN cord-023095-4dannjjm 2237 28 ) ) -RRB- cord-023095-4dannjjm 2237 29 for for IN cord-023095-4dannjjm 2237 30 four four CD cord-023095-4dannjjm 2237 31 different different JJ cord-023095-4dannjjm 2237 32 serum serum NN cord-023095-4dannjjm 2237 33 samples sample NNS cord-023095-4dannjjm 2237 34 at at IN cord-023095-4dannjjm 2237 35 dilutions dilution NNS cord-023095-4dannjjm 2237 36 of of IN cord-023095-4dannjjm 2237 37 1:1 1:1 CD cord-023095-4dannjjm 2237 38 , , , cord-023095-4dannjjm 2237 39 1:2 1:2 CD cord-023095-4dannjjm 2237 40 , , , cord-023095-4dannjjm 2237 41 and and CC cord-023095-4dannjjm 2237 42 1:4 1:4 CD cord-023095-4dannjjm 2237 43 , , , cord-023095-4dannjjm 2237 44 and and CC cord-023095-4dannjjm 2237 45 from from IN cord-023095-4dannjjm 2237 46 96.8 96.8 CD cord-023095-4dannjjm 2237 47 to to IN cord-023095-4dannjjm 2237 48 118.3 118.3 CD cord-023095-4dannjjm 2237 49 % % NN cord-023095-4dannjjm 2237 50 ( ( -LRB- cord-023095-4dannjjm 2237 51 mean mean VB cord-023095-4dannjjm 2237 52 AE AE NNP cord-023095-4dannjjm 2237 53 SD SD NNP cord-023095-4dannjjm 2237 54 : : : cord-023095-4dannjjm 2237 55 107.6 107.6 CD cord-023095-4dannjjm 2237 56 AE AE NNP cord-023095-4dannjjm 2237 57 15.2 15.2 CD cord-023095-4dannjjm 2237 58 % % NN cord-023095-4dannjjm 2237 59 ) ) -RRB- cord-023095-4dannjjm 2237 60 for for IN cord-023095-4dannjjm 2237 61 one one CD cord-023095-4dannjjm 2237 62 serum serum NN cord-023095-4dannjjm 2237 63 sample sample NN cord-023095-4dannjjm 2237 64 at at IN cord-023095-4dannjjm 2237 65 dilutions dilution NNS cord-023095-4dannjjm 2237 66 of of IN cord-023095-4dannjjm 2237 67 1:2 1:2 CD cord-023095-4dannjjm 2237 68 , , , cord-023095-4dannjjm 2237 69 1:4 1:4 CD cord-023095-4dannjjm 2237 70 , , , cord-023095-4dannjjm 2237 71 and and CC cord-023095-4dannjjm 2237 72 1:8 1:8 CD cord-023095-4dannjjm 2237 73 . . . cord-023095-4dannjjm 2238 1 O o UH cord-023095-4dannjjm 2238 2 / / SYM cord-023095-4dannjjm 2238 3 E e NN cord-023095-4dannjjm 2238 4 for for IN cord-023095-4dannjjm 2238 5 spiking spike VBG cord-023095-4dannjjm 2238 6 recovery recovery NN cord-023095-4dannjjm 2238 7 ranged range VBD cord-023095-4dannjjm 2238 8 from from IN cord-023095-4dannjjm 2238 9 87.4 87.4 CD cord-023095-4dannjjm 2238 10 to to IN cord-023095-4dannjjm 2238 11 116.7 116.7 CD cord-023095-4dannjjm 2238 12 % % NN cord-023095-4dannjjm 2239 1 ( ( -LRB- cord-023095-4dannjjm 2239 2 mean mean VB cord-023095-4dannjjm 2239 3 AE AE NNP cord-023095-4dannjjm 2239 4 SD SD NNP cord-023095-4dannjjm 2239 5 : : : cord-023095-4dannjjm 2240 1 102.0 102.0 CD cord-023095-4dannjjm 2240 2 AE AE NNP cord-023095-4dannjjm 2240 3 7.5 7.5 CD cord-023095-4dannjjm 2240 4 % % NN cord-023095-4dannjjm 2240 5 ) ) -RRB- cord-023095-4dannjjm 2240 6 for for IN cord-023095-4dannjjm 2240 7 five five CD cord-023095-4dannjjm 2240 8 different different JJ cord-023095-4dannjjm 2240 9 porcine porcine JJ cord-023095-4dannjjm 2240 10 serum serum NN cord-023095-4dannjjm 2240 11 samples sample NNS cord-023095-4dannjjm 2240 12 that that WDT cord-023095-4dannjjm 2240 13 had have VBD cord-023095-4dannjjm 2240 14 been be VBN cord-023095-4dannjjm 2240 15 spiked spike VBN cord-023095-4dannjjm 2240 16 with with IN cord-023095-4dannjjm 2240 17 each each DT cord-023095-4dannjjm 2240 18 other other JJ cord-023095-4dannjjm 2240 19 in in IN cord-023095-4dannjjm 2240 20 a a DT cord-023095-4dannjjm 2240 21 1:1 1:1 CD cord-023095-4dannjjm 2240 22 dilution dilution NN cord-023095-4dannjjm 2240 23 . . . cord-023095-4dannjjm 2241 1 Intraassay Intraassay NNP cord-023095-4dannjjm 2241 2 coefficients coefficient NNS cord-023095-4dannjjm 2241 3 of of IN cord-023095-4dannjjm 2241 4 variation variation NN cord-023095-4dannjjm 2241 5 ( ( -LRB- cord-023095-4dannjjm 2241 6 % % NN cord-023095-4dannjjm 2241 7 CV CV NNP cord-023095-4dannjjm 2241 8 ) ) -RRB- cord-023095-4dannjjm 2241 9 for for IN cord-023095-4dannjjm 2241 10 five five CD cord-023095-4dannjjm 2241 11 different different JJ cord-023095-4dannjjm 2241 12 serum serum NN cord-023095-4dannjjm 2241 13 samples sample NNS cord-023095-4dannjjm 2241 14 were be VBD cord-023095-4dannjjm 2241 15 4.3 4.3 CD cord-023095-4dannjjm 2241 16 , , , cord-023095-4dannjjm 2241 17 5.7 5.7 CD cord-023095-4dannjjm 2241 18 , , , cord-023095-4dannjjm 2241 19 4.3 4.3 CD cord-023095-4dannjjm 2241 20 , , , cord-023095-4dannjjm 2241 21 3.7 3.7 CD cord-023095-4dannjjm 2241 22 , , , cord-023095-4dannjjm 2241 23 and and CC cord-023095-4dannjjm 2241 24 6.1 6.1 CD cord-023095-4dannjjm 2241 25 % % NN cord-023095-4dannjjm 2241 26 . . . cord-023095-4dannjjm 2242 1 Inter inter JJ cord-023095-4dannjjm 2242 2 - - JJ cord-023095-4dannjjm 2242 3 assay assay NN cord-023095-4dannjjm 2242 4 % % NN cord-023095-4dannjjm 2242 5 CVs cv NNS cord-023095-4dannjjm 2242 6 for for IN cord-023095-4dannjjm 2242 7 five five CD cord-023095-4dannjjm 2242 8 different different JJ cord-023095-4dannjjm 2242 9 serum serum NN cord-023095-4dannjjm 2242 10 samples sample NNS cord-023095-4dannjjm 2242 11 were be VBD cord-023095-4dannjjm 2242 12 4.9 4.9 CD cord-023095-4dannjjm 2242 13 , , , cord-023095-4dannjjm 2242 14 7.2 7.2 CD cord-023095-4dannjjm 2242 15 , , , cord-023095-4dannjjm 2242 16 9.6 9.6 CD cord-023095-4dannjjm 2242 17 , , , cord-023095-4dannjjm 2242 18 3.5 3.5 CD cord-023095-4dannjjm 2242 19 , , , cord-023095-4dannjjm 2242 20 and and CC cord-023095-4dannjjm 2242 21 7.6 7.6 CD cord-023095-4dannjjm 2242 22 % % NN cord-023095-4dannjjm 2242 23 . . . cord-023095-4dannjjm 2243 1 Serum serum NN cord-023095-4dannjjm 2243 2 cobalamin cobalamin NN cord-023095-4dannjjm 2243 3 concentration concentration NN cord-023095-4dannjjm 2243 4 was be VBD cord-023095-4dannjjm 2243 5 significantly significantly RB cord-023095-4dannjjm 2243 6 lower low JJR cord-023095-4dannjjm 2243 7 in in IN cord-023095-4dannjjm 2243 8 piglets piglet NNS cord-023095-4dannjjm 2244 1 post post JJ cord-023095-4dannjjm 2244 2 weaning weaning NN cord-023095-4dannjjm 2244 3 ( ( -LRB- cord-023095-4dannjjm 2244 4 median median NN cord-023095-4dannjjm 2244 5 : : : cord-023095-4dannjjm 2244 6 242 242 CD cord-023095-4dannjjm 2244 7 ng ng NNP cord-023095-4dannjjm 2244 8 / / SYM cord-023095-4dannjjm 2244 9 L L NNP cord-023095-4dannjjm 2244 10 ) ) -RRB- cord-023095-4dannjjm 2244 11 compared compare VBN cord-023095-4dannjjm 2244 12 to to IN cord-023095-4dannjjm 2244 13 those those DT cord-023095-4dannjjm 2244 14 at at IN cord-023095-4dannjjm 2244 15 the the DT cord-023095-4dannjjm 2244 16 time time NN cord-023095-4dannjjm 2244 17 of of IN cord-023095-4dannjjm 2244 18 weaning weaning NN cord-023095-4dannjjm 2244 19 ( ( -LRB- cord-023095-4dannjjm 2244 20 median median NN cord-023095-4dannjjm 2244 21 : : : cord-023095-4dannjjm 2244 22 324 324 CD cord-023095-4dannjjm 2244 23 ng ng NNP cord-023095-4dannjjm 2244 24 / / SYM cord-023095-4dannjjm 2244 25 L l NN cord-023095-4dannjjm 2244 26 ; ; : cord-023095-4dannjjm 2244 27 p p NN cord-023095-4dannjjm 2244 28 5 5 CD cord-023095-4dannjjm 2244 29 0.009 0.009 CD cord-023095-4dannjjm 2244 30 ) ) -RRB- cord-023095-4dannjjm 2244 31 . . . cord-023095-4dannjjm 2245 1 The the DT cord-023095-4dannjjm 2245 2 IMMULITE IMMULITE NNP cord-023095-4dannjjm 2245 3 s s NNP cord-023095-4dannjjm 2245 4 2000 2000 CD cord-023095-4dannjjm 2245 5 cobalamin cobalamin NN cord-023095-4dannjjm 2245 6 immunoassay immunoassay NN cord-023095-4dannjjm 2245 7 labeled label VBN cord-023095-4dannjjm 2245 8 for for IN cord-023095-4dannjjm 2245 9 use use NN cord-023095-4dannjjm 2245 10 in in IN cord-023095-4dannjjm 2245 11 humans human NNS cord-023095-4dannjjm 2245 12 is be VBZ cord-023095-4dannjjm 2245 13 linear linear JJ cord-023095-4dannjjm 2245 14 , , , cord-023095-4dannjjm 2245 15 accurate accurate JJ cord-023095-4dannjjm 2245 16 , , , cord-023095-4dannjjm 2245 17 precise precise JJ cord-023095-4dannjjm 2245 18 , , , cord-023095-4dannjjm 2245 19 and and CC cord-023095-4dannjjm 2245 20 reproducible reproducible JJ cord-023095-4dannjjm 2245 21 for for IN cord-023095-4dannjjm 2245 22 measurement measurement NN cord-023095-4dannjjm 2245 23 of of IN cord-023095-4dannjjm 2245 24 serum serum NN cord-023095-4dannjjm 2245 25 cobalamin cobalamin NN cord-023095-4dannjjm 2245 26 concentrations concentration NNS cord-023095-4dannjjm 2245 27 in in IN cord-023095-4dannjjm 2245 28 pigs pig NNS cord-023095-4dannjjm 2245 29 . . . cord-023095-4dannjjm 2246 1 This this DT cord-023095-4dannjjm 2246 2 study study NN cord-023095-4dannjjm 2246 3 also also RB cord-023095-4dannjjm 2246 4 showed show VBD cord-023095-4dannjjm 2246 5 that that IN cord-023095-4dannjjm 2246 6 piglets piglet NNS cord-023095-4dannjjm 2246 7 that that WDT cord-023095-4dannjjm 2246 8 differ differ VBP cord-023095-4dannjjm 2246 9 in in IN cord-023095-4dannjjm 2246 10 age age NN cord-023095-4dannjjm 2246 11 by by IN cord-023095-4dannjjm 2246 12 only only RB cord-023095-4dannjjm 2246 13 12 12 CD cord-023095-4dannjjm 2246 14 days day NNS cord-023095-4dannjjm 2246 15 have have VBP cord-023095-4dannjjm 2246 16 significantly significantly RB cord-023095-4dannjjm 2246 17 different different JJ cord-023095-4dannjjm 2246 18 serum serum NN cord-023095-4dannjjm 2246 19 cobalamin cobalamin NN cord-023095-4dannjjm 2246 20 concentrations concentration NNS cord-023095-4dannjjm 2246 21 . . . cord-023095-4dannjjm 2247 1 Further further JJ cord-023095-4dannjjm 2247 2 investigations investigation NNS cord-023095-4dannjjm 2247 3 of of IN cord-023095-4dannjjm 2247 4 cobalamin cobalamin NN cord-023095-4dannjjm 2247 5 concentrations concentration NNS cord-023095-4dannjjm 2247 6 in in IN cord-023095-4dannjjm 2247 7 both both DT cord-023095-4dannjjm 2247 8 sows sow NNS cord-023095-4dannjjm 2247 9 and and CC cord-023095-4dannjjm 2247 10 piglets piglet NNS cord-023095-4dannjjm 2247 11 at at IN cord-023095-4dannjjm 2247 12 different different JJ cord-023095-4dannjjm 2247 13 stages stage NNS cord-023095-4dannjjm 2247 14 of of IN cord-023095-4dannjjm 2247 15 weaning weaning NN cord-023095-4dannjjm 2247 16 are be VBP cord-023095-4dannjjm 2247 17 warranted warrant VBN cord-023095-4dannjjm 2247 18 . . . cord-023095-4dannjjm 2248 1 Primigravid Primigravid NNP cord-023095-4dannjjm 2248 2 dairy dairy NN cord-023095-4dannjjm 2248 3 heifers heifer NNS cord-023095-4dannjjm 2248 4 can can MD cord-023095-4dannjjm 2248 5 be be VB cord-023095-4dannjjm 2248 6 infected infect VBN cord-023095-4dannjjm 2248 7 with with IN cord-023095-4dannjjm 2248 8 mastitis mastitis NN cord-023095-4dannjjm 2248 9 pathogens pathogen NNS cord-023095-4dannjjm 2248 10 during during IN cord-023095-4dannjjm 2248 11 the the DT cord-023095-4dannjjm 2248 12 periparturient periparturient JJ cord-023095-4dannjjm 2248 13 period period NN cord-023095-4dannjjm 2248 14 . . . cord-023095-4dannjjm 2249 1 The the DT cord-023095-4dannjjm 2249 2 prevalence prevalence NN cord-023095-4dannjjm 2249 3 of of IN cord-023095-4dannjjm 2249 4 intramammary intramammary JJ cord-023095-4dannjjm 2249 5 infection infection NN cord-023095-4dannjjm 2249 6 ( ( -LRB- cord-023095-4dannjjm 2249 7 IMI IMI NNP cord-023095-4dannjjm 2249 8 ) ) -RRB- cord-023095-4dannjjm 2249 9 ranges range VBZ cord-023095-4dannjjm 2249 10 from from IN cord-023095-4dannjjm 2249 11 30 30 CD cord-023095-4dannjjm 2249 12 - - SYM cord-023095-4dannjjm 2249 13 75 75 CD cord-023095-4dannjjm 2249 14 % % NN cord-023095-4dannjjm 2249 15 of of IN cord-023095-4dannjjm 2249 16 quarters quarter NNS cord-023095-4dannjjm 2249 17 pre pre JJ cord-023095-4dannjjm 2249 18 - - JJ cord-023095-4dannjjm 2249 19 partum partum JJ cord-023095-4dannjjm 2249 20 and and CC cord-023095-4dannjjm 2249 21 12 12 CD cord-023095-4dannjjm 2249 22 - - SYM cord-023095-4dannjjm 2249 23 45 45 CD cord-023095-4dannjjm 2249 24 % % NN cord-023095-4dannjjm 2249 25 at at IN cord-023095-4dannjjm 2249 26 parturition parturition NN cord-023095-4dannjjm 2249 27 . . . cord-023095-4dannjjm 2250 1 Some some DT cord-023095-4dannjjm 2250 2 pre pre JJ cord-023095-4dannjjm 2250 3 - - JJ cord-023095-4dannjjm 2250 4 partum partum JJ cord-023095-4dannjjm 2250 5 infections infection NNS cord-023095-4dannjjm 2250 6 self self NN cord-023095-4dannjjm 2250 7 - - HYPH cord-023095-4dannjjm 2250 8 cure cure NN cord-023095-4dannjjm 2250 9 before before IN cord-023095-4dannjjm 2250 10 parturition parturition NN cord-023095-4dannjjm 2250 11 , , , cord-023095-4dannjjm 2250 12 however however RB cord-023095-4dannjjm 2250 13 a a DT cord-023095-4dannjjm 2250 14 number number NN cord-023095-4dannjjm 2250 15 of of IN cord-023095-4dannjjm 2250 16 these these DT cord-023095-4dannjjm 2250 17 IMIs imi NNS cord-023095-4dannjjm 2250 18 persist persist VBP cord-023095-4dannjjm 2250 19 into into IN cord-023095-4dannjjm 2250 20 early early JJ cord-023095-4dannjjm 2250 21 lactation lactation NN cord-023095-4dannjjm 2250 22 . . . cord-023095-4dannjjm 2251 1 These these DT cord-023095-4dannjjm 2251 2 IMIs imi NNS cord-023095-4dannjjm 2251 3 may may MD cord-023095-4dannjjm 2251 4 impact impact VB cord-023095-4dannjjm 2251 5 milk milk NN cord-023095-4dannjjm 2251 6 production production NN cord-023095-4dannjjm 2251 7 and and CC cord-023095-4dannjjm 2251 8 quality quality NN cord-023095-4dannjjm 2251 9 and and CC cord-023095-4dannjjm 2251 10 may may MD cord-023095-4dannjjm 2251 11 serve serve VB cord-023095-4dannjjm 2251 12 as as IN cord-023095-4dannjjm 2251 13 a a DT cord-023095-4dannjjm 2251 14 reservoir reservoir NN cord-023095-4dannjjm 2251 15 for for IN cord-023095-4dannjjm 2251 16 contagious contagious JJ cord-023095-4dannjjm 2251 17 pathogens pathogen NNS cord-023095-4dannjjm 2251 18 . . . cord-023095-4dannjjm 2252 1 No no DT cord-023095-4dannjjm 2252 2 study study NN cord-023095-4dannjjm 2252 3 has have VBZ cord-023095-4dannjjm 2252 4 specifically specifically RB cord-023095-4dannjjm 2252 5 investigated investigate VBN cord-023095-4dannjjm 2252 6 the the DT cord-023095-4dannjjm 2252 7 risk risk NN cord-023095-4dannjjm 2252 8 of of IN cord-023095-4dannjjm 2252 9 an an DT cord-023095-4dannjjm 2252 10 IMI IMI NNP cord-023095-4dannjjm 2252 11 persisting persist VBG cord-023095-4dannjjm 2252 12 from from IN cord-023095-4dannjjm 2252 13 the the DT cord-023095-4dannjjm 2252 14 prepartum prepartum NN cord-023095-4dannjjm 2252 15 period period NN cord-023095-4dannjjm 2252 16 into into IN cord-023095-4dannjjm 2252 17 early early JJ cord-023095-4dannjjm 2252 18 lactation lactation NN cord-023095-4dannjjm 2252 19 . . . cord-023095-4dannjjm 2253 1 The the DT cord-023095-4dannjjm 2253 2 objectives objective NNS cord-023095-4dannjjm 2253 3 of of IN cord-023095-4dannjjm 2253 4 this this DT cord-023095-4dannjjm 2253 5 study study NN cord-023095-4dannjjm 2253 6 were be VBD cord-023095-4dannjjm 2253 7 to to TO cord-023095-4dannjjm 2253 8 describe describe VB cord-023095-4dannjjm 2253 9 the the DT cord-023095-4dannjjm 2253 10 prevalence prevalence NN cord-023095-4dannjjm 2253 11 of of IN cord-023095-4dannjjm 2253 12 mastitis mastitis NN cord-023095-4dannjjm 2253 13 pathogens pathogen NNS cord-023095-4dannjjm 2253 14 in in IN cord-023095-4dannjjm 2253 15 heifers heifer NNS cord-023095-4dannjjm 2253 16 on on IN cord-023095-4dannjjm 2253 17 a a DT cord-023095-4dannjjm 2253 18 grazing graze VBG cord-023095-4dannjjm 2253 19 dairy dairy NN cord-023095-4dannjjm 2253 20 before before IN cord-023095-4dannjjm 2253 21 and and CC cord-023095-4dannjjm 2253 22 after after IN cord-023095-4dannjjm 2253 23 parturition parturition NN cord-023095-4dannjjm 2253 24 and and CC cord-023095-4dannjjm 2253 25 calculate calculate VB cord-023095-4dannjjm 2253 26 the the DT cord-023095-4dannjjm 2253 27 relative relative JJ cord-023095-4dannjjm 2253 28 risk risk NN cord-023095-4dannjjm 2253 29 ( ( -LRB- cord-023095-4dannjjm 2253 30 RR rr NN cord-023095-4dannjjm 2253 31 ) ) -RRB- cord-023095-4dannjjm 2253 32 and and CC cord-023095-4dannjjm 2253 33 attributable attributable JJ cord-023095-4dannjjm 2253 34 fraction fraction NN cord-023095-4dannjjm 2253 35 of of IN cord-023095-4dannjjm 2253 36 population population NN cord-023095-4dannjjm 2253 37 ( ( -LRB- cord-023095-4dannjjm 2253 38 AFP AFP NNP cord-023095-4dannjjm 2253 39 ) ) -RRB- cord-023095-4dannjjm 2253 40 for for IN cord-023095-4dannjjm 2253 41 the the DT cord-023095-4dannjjm 2253 42 association association NN cord-023095-4dannjjm 2253 43 between between IN cord-023095-4dannjjm 2253 44 a a DT cord-023095-4dannjjm 2253 45 post post JJ cord-023095-4dannjjm 2253 46 - - JJ cord-023095-4dannjjm 2253 47 partum partum JJ cord-023095-4dannjjm 2253 48 and and CC cord-023095-4dannjjm 2253 49 pre pre JJ cord-023095-4dannjjm 2253 50 - - JJ cord-023095-4dannjjm 2253 51 partum partum JJ cord-023095-4dannjjm 2253 52 IMI IMI NNP cord-023095-4dannjjm 2253 53 . . . cord-023095-4dannjjm 2254 1 Two two CD cord-023095-4dannjjm 2254 2 - - HYPH cord-023095-4dannjjm 2254 3 hundred hundred CD cord-023095-4dannjjm 2254 4 - - HYPH cord-023095-4dannjjm 2254 5 ninety ninety CD cord-023095-4dannjjm 2254 6 - - HYPH cord-023095-4dannjjm 2254 7 four four CD cord-023095-4dannjjm 2254 8 heifers heifer NNS cord-023095-4dannjjm 2254 9 were be VBD cord-023095-4dannjjm 2254 10 systematically systematically RB cord-023095-4dannjjm 2254 11 assigned assign VBN cord-023095-4dannjjm 2254 12 to to IN cord-023095-4dannjjm 2254 13 1 1 CD cord-023095-4dannjjm 2254 14 of of IN cord-023095-4dannjjm 2254 15 3 3 CD cord-023095-4dannjjm 2254 16 groups group NNS cord-023095-4dannjjm 2254 17 : : : cord-023095-4dannjjm 2254 18 G1 G1 NNP cord-023095-4dannjjm 2254 19 ) ) -RRB- cord-023095-4dannjjm 2254 20 pre pre JJ cord-023095-4dannjjm 2254 21 - - JJ cord-023095-4dannjjm 2254 22 partum partum JJ cord-023095-4dannjjm 2254 23 secretions secretion NNS cord-023095-4dannjjm 2254 24 from from IN cord-023095-4dannjjm 2254 25 all all DT cord-023095-4dannjjm 2254 26 mammary mammary JJ cord-023095-4dannjjm 2254 27 quarters quarter NNS cord-023095-4dannjjm 2254 28 ( ( -LRB- cord-023095-4dannjjm 2254 29 n n NN cord-023095-4dannjjm 2254 30 5 5 CD cord-023095-4dannjjm 2254 31 98 98 CD cord-023095-4dannjjm 2254 32 ) ) -RRB- cord-023095-4dannjjm 2254 33 , , , cord-023095-4dannjjm 2254 34 G2 G2 NNP cord-023095-4dannjjm 2254 35 ) ) -RRB- cord-023095-4dannjjm 2255 1 no no DT cord-023095-4dannjjm 2255 2 pre pre JJ cord-023095-4dannjjm 2255 3 - - JJ cord-023095-4dannjjm 2255 4 partum partum JJ cord-023095-4dannjjm 2255 5 secretions secretion NNS cord-023095-4dannjjm 2255 6 collected collect VBN cord-023095-4dannjjm 2255 7 ( ( -LRB- cord-023095-4dannjjm 2255 8 n n NN cord-023095-4dannjjm 2255 9 5 5 CD cord-023095-4dannjjm 2255 10 98 98 CD cord-023095-4dannjjm 2255 11 ) ) -RRB- cord-023095-4dannjjm 2255 12 and and CC cord-023095-4dannjjm 2255 13 G3 G3 NNP cord-023095-4dannjjm 2255 14 ) ) -RRB- cord-023095-4dannjjm 2255 15 pre pre JJ cord-023095-4dannjjm 2255 16 - - JJ cord-023095-4dannjjm 2255 17 partum partum JJ cord-023095-4dannjjm 2255 18 secretions secretion NNS cord-023095-4dannjjm 2255 19 from from IN cord-023095-4dannjjm 2255 20 two two CD cord-023095-4dannjjm 2255 21 diagonal diagonal JJ cord-023095-4dannjjm 2255 22 quarters quarter NNS cord-023095-4dannjjm 2255 23 ( ( -LRB- cord-023095-4dannjjm 2255 24 n n NN cord-023095-4dannjjm 2255 25 5 5 CD cord-023095-4dannjjm 2255 26 98 98 CD cord-023095-4dannjjm 2255 27 ) ) -RRB- cord-023095-4dannjjm 2255 28 . . . cord-023095-4dannjjm 2256 1 Group group NN cord-023095-4dannjjm 2256 2 assignments assignment NNS cord-023095-4dannjjm 2256 3 were be VBD cord-023095-4dannjjm 2256 4 designed design VBN cord-023095-4dannjjm 2256 5 to to TO cord-023095-4dannjjm 2256 6 assess assess VB cord-023095-4dannjjm 2256 7 whether whether IN cord-023095-4dannjjm 2256 8 pre pre JJ cord-023095-4dannjjm 2256 9 - - JJ cord-023095-4dannjjm 2256 10 partum partum JJ cord-023095-4dannjjm 2256 11 sampling sampling NN cord-023095-4dannjjm 2256 12 increased increase VBD cord-023095-4dannjjm 2256 13 the the DT cord-023095-4dannjjm 2256 14 likelihood likelihood NN cord-023095-4dannjjm 2256 15 of of IN cord-023095-4dannjjm 2256 16 IMI IMI NNP cord-023095-4dannjjm 2256 17 at at IN cord-023095-4dannjjm 2256 18 calving calving NN cord-023095-4dannjjm 2256 19 . . . cord-023095-4dannjjm 2257 1 Mammary mammary JJ cord-023095-4dannjjm 2257 2 quarter quarter NN cord-023095-4dannjjm 2257 3 secretions secretion NNS cord-023095-4dannjjm 2257 4 were be VBD cord-023095-4dannjjm 2257 5 collected collect VBN cord-023095-4dannjjm 2257 6 for for IN cord-023095-4dannjjm 2257 7 bacterial bacterial JJ cord-023095-4dannjjm 2257 8 culture culture NN cord-023095-4dannjjm 2257 9 approximately approximately RB cord-023095-4dannjjm 2257 10 2 2 CD cord-023095-4dannjjm 2257 11 weeks week NNS cord-023095-4dannjjm 2257 12 prior prior RB cord-023095-4dannjjm 2257 13 to to IN cord-023095-4dannjjm 2257 14 expected expect VBN cord-023095-4dannjjm 2257 15 calving calving NN cord-023095-4dannjjm 2257 16 date date NN cord-023095-4dannjjm 2257 17 . . . cord-023095-4dannjjm 2258 1 Quarter quarter NN cord-023095-4dannjjm 2258 2 milk milk NN cord-023095-4dannjjm 2258 3 samples sample NNS cord-023095-4dannjjm 2258 4 were be VBD cord-023095-4dannjjm 2258 5 collected collect VBN cord-023095-4dannjjm 2258 6 for for IN cord-023095-4dannjjm 2258 7 bacterial bacterial JJ cord-023095-4dannjjm 2258 8 culture culture NN cord-023095-4dannjjm 2258 9 once once RB cord-023095-4dannjjm 2258 10 weekly weekly RB cord-023095-4dannjjm 2258 11 during during IN cord-023095-4dannjjm 2258 12 the the DT cord-023095-4dannjjm 2258 13 1 1 CD cord-023095-4dannjjm 2258 14 st st NNP cord-023095-4dannjjm 2258 15 3-weeks 3-weeks CD cord-023095-4dannjjm 2258 16 of of IN cord-023095-4dannjjm 2258 17 lactation lactation NN cord-023095-4dannjjm 2258 18 . . . cord-023095-4dannjjm 2259 1 Bacterial bacterial JJ cord-023095-4dannjjm 2259 2 isolates isolate NNS cord-023095-4dannjjm 2259 3 were be VBD cord-023095-4dannjjm 2259 4 classified classify VBN cord-023095-4dannjjm 2259 5 as as IN cord-023095-4dannjjm 2259 6 staphylococci staphylococcus NNS cord-023095-4dannjjm 2259 7 , , , cord-023095-4dannjjm 2259 8 non non JJ cord-023095-4dannjjm 2259 9 - - JJ cord-023095-4dannjjm 2259 10 agalactiae agalactiae JJ cord-023095-4dannjjm 2259 11 streptococci streptococcus NNS cord-023095-4dannjjm 2259 12 and and CC cord-023095-4dannjjm 2259 13 Gram gram NN cord-023095-4dannjjm 2259 14 - - HYPH cord-023095-4dannjjm 2259 15 negatives negative NNS cord-023095-4dannjjm 2259 16 . . . cord-023095-4dannjjm 2260 1 Mammary mammary JJ cord-023095-4dannjjm 2260 2 quarter quarter NN cord-023095-4dannjjm 2260 3 samples sample NNS cord-023095-4dannjjm 2260 4 yielding yield VBG cord-023095-4dannjjm 2260 5 2 2 CD cord-023095-4dannjjm 2260 6 different different JJ cord-023095-4dannjjm 2260 7 bacteria bacteria NNS cord-023095-4dannjjm 2260 8 were be VBD cord-023095-4dannjjm 2260 9 classified classify VBN cord-023095-4dannjjm 2260 10 as as IN cord-023095-4dannjjm 2260 11 mixed mixed JJ cord-023095-4dannjjm 2260 12 infections infection NNS cord-023095-4dannjjm 2260 13 and and CC cord-023095-4dannjjm 2260 14 those those DT cord-023095-4dannjjm 2260 15 yielding yield VBG cord-023095-4dannjjm 2260 16 ! ! . cord-023095-4dannjjm 2261 1 3 3 CD cord-023095-4dannjjm 2261 2 bacterial bacterial JJ cord-023095-4dannjjm 2261 3 types type NNS cord-023095-4dannjjm 2261 4 were be VBD cord-023095-4dannjjm 2261 5 classified classify VBN cord-023095-4dannjjm 2261 6 as as IN cord-023095-4dannjjm 2261 7 contaminated contaminate VBN cord-023095-4dannjjm 2261 8 . . . cord-023095-4dannjjm 2262 1 Bacterial bacterial JJ cord-023095-4dannjjm 2262 2 isolates isolate NNS cord-023095-4dannjjm 2262 3 were be VBD cord-023095-4dannjjm 2262 4 speciated speciate VBN cord-023095-4dannjjm 2262 5 using use VBG cord-023095-4dannjjm 2262 6 gene gene NN cord-023095-4dannjjm 2262 7 sequencing sequencing NN cord-023095-4dannjjm 2262 8 methods method NNS cord-023095-4dannjjm 2262 9 and and CC cord-023095-4dannjjm 2262 10 strain strain NN cord-023095-4dannjjm 2262 11 - - HYPH cord-023095-4dannjjm 2262 12 typed type VBN cord-023095-4dannjjm 2262 13 using use VBG cord-023095-4dannjjm 2262 14 pulse pulse NN cord-023095-4dannjjm 2262 15 - - HYPH cord-023095-4dannjjm 2262 16 field field NN cord-023095-4dannjjm 2262 17 - - HYPH cord-023095-4dannjjm 2262 18 gel gel NN cord-023095-4dannjjm 2262 19 - - HYPH cord-023095-4dannjjm 2262 20 electrophorysis electrophorysis NN cord-023095-4dannjjm 2262 21 to to TO cord-023095-4dannjjm 2262 22 evaluate evaluate VB cord-023095-4dannjjm 2262 23 the the DT cord-023095-4dannjjm 2262 24 relatedness relatedness NN cord-023095-4dannjjm 2262 25 of of IN cord-023095-4dannjjm 2262 26 bacteria bacteria NNS cord-023095-4dannjjm 2262 27 isolated isolate VBN cord-023095-4dannjjm 2262 28 from from IN cord-023095-4dannjjm 2262 29 pre pre JJ cord-023095-4dannjjm 2262 30 - - JJ cord-023095-4dannjjm 2262 31 and and CC cord-023095-4dannjjm 2262 32 post post JJ cord-023095-4dannjjm 2262 33 - - JJ cord-023095-4dannjjm 2262 34 partum partum JJ cord-023095-4dannjjm 2262 35 samples sample NNS cord-023095-4dannjjm 2262 36 from from IN cord-023095-4dannjjm 2262 37 the the DT cord-023095-4dannjjm 2262 38 same same JJ cord-023095-4dannjjm 2262 39 mammary mammary JJ cord-023095-4dannjjm 2262 40 quarter quarter NN cord-023095-4dannjjm 2262 41 . . . cord-023095-4dannjjm 2263 1 Relative relative JJ cord-023095-4dannjjm 2263 2 risk risk NN cord-023095-4dannjjm 2263 3 and and CC cord-023095-4dannjjm 2263 4 AFP AFP NNP cord-023095-4dannjjm 2263 5 were be VBD cord-023095-4dannjjm 2263 6 calculated calculate VBN cord-023095-4dannjjm 2263 7 using use VBG cord-023095-4dannjjm 2263 8 2 2 CD cord-023095-4dannjjm 2263 9 Â â CD cord-023095-4dannjjm 2263 10 2 2 CD cord-023095-4dannjjm 2263 11 tables table NNS cord-023095-4dannjjm 2263 12 . . . cord-023095-4dannjjm 2264 1 Forty forty CD cord-023095-4dannjjm 2264 2 - - HYPH cord-023095-4dannjjm 2264 3 five five CD cord-023095-4dannjjm 2264 4 percent percent NN cord-023095-4dannjjm 2264 5 of of IN cord-023095-4dannjjm 2264 6 mammary mammary JJ cord-023095-4dannjjm 2264 7 quarters quarter NNS cord-023095-4dannjjm 2264 8 had have VBD cord-023095-4dannjjm 2264 9 a a DT cord-023095-4dannjjm 2264 10 pre pre JJ cord-023095-4dannjjm 2264 11 - - JJ cord-023095-4dannjjm 2264 12 partum partum JJ cord-023095-4dannjjm 2264 13 IMI IMI NNP cord-023095-4dannjjm 2264 14 . . . cord-023095-4dannjjm 2265 1 During during IN cord-023095-4dannjjm 2265 2 the the DT cord-023095-4dannjjm 2265 3 1st 1st JJ cord-023095-4dannjjm 2265 4 3 3 CD cord-023095-4dannjjm 2265 5 weeks week NNS cord-023095-4dannjjm 2265 6 of of IN cord-023095-4dannjjm 2265 7 lactation lactation NN cord-023095-4dannjjm 2265 8 the the DT cord-023095-4dannjjm 2265 9 mean mean JJ cord-023095-4dannjjm 2265 10 prevalence prevalence NN cord-023095-4dannjjm 2265 11 of of IN cord-023095-4dannjjm 2265 12 IMI IMI NNP cord-023095-4dannjjm 2265 13 was be VBD cord-023095-4dannjjm 2265 14 23.3 23.3 CD cord-023095-4dannjjm 2265 15 % % NN cord-023095-4dannjjm 2265 16 of of IN cord-023095-4dannjjm 2265 17 quarters quarter NNS cord-023095-4dannjjm 2265 18 . . . cord-023095-4dannjjm 2266 1 Staphylococci staphylococcus NNS cord-023095-4dannjjm 2266 2 were be VBD cord-023095-4dannjjm 2266 3 most most RBS cord-023095-4dannjjm 2266 4 frequently frequently RB cord-023095-4dannjjm 2266 5 isolated isolate VBN cord-023095-4dannjjm 2266 6 bacteria bacteria NNS cord-023095-4dannjjm 2266 7 from from IN cord-023095-4dannjjm 2266 8 pre pre JJ cord-023095-4dannjjm 2266 9 - - JJ cord-023095-4dannjjm 2266 10 partum partum JJ cord-023095-4dannjjm 2266 11 secretions secretion NNS cord-023095-4dannjjm 2266 12 and and CC cord-023095-4dannjjm 2266 13 milk milk NN cord-023095-4dannjjm 2266 14 with with IN cord-023095-4dannjjm 2266 15 S. S. NNP cord-023095-4dannjjm 2266 16 chromogenes chromogene NNS cord-023095-4dannjjm 2266 17 and and CC cord-023095-4dannjjm 2266 18 S. S. NNP cord-023095-4dannjjm 2266 19 aureus aureus NN cord-023095-4dannjjm 2266 20 being be VBG cord-023095-4dannjjm 2266 21 the the DT cord-023095-4dannjjm 2266 22 most most RBS cord-023095-4dannjjm 2266 23 common common JJ cord-023095-4dannjjm 2266 24 species specie NNS cord-023095-4dannjjm 2266 25 . . . cord-023095-4dannjjm 2267 1 Using use VBG cord-023095-4dannjjm 2267 2 data datum NNS cord-023095-4dannjjm 2267 3 from from IN cord-023095-4dannjjm 2267 4 228 228 CD cord-023095-4dannjjm 2267 5 mammary mammary JJ cord-023095-4dannjjm 2267 6 quarters quarter NNS cord-023095-4dannjjm 2267 7 , , , cord-023095-4dannjjm 2267 8 the the DT cord-023095-4dannjjm 2267 9 RR RR NNP cord-023095-4dannjjm 2267 10 and and CC cord-023095-4dannjjm 2267 11 AFP AFP NNP cord-023095-4dannjjm 2267 12 for for IN cord-023095-4dannjjm 2267 13 the the DT cord-023095-4dannjjm 2267 14 association association NN cord-023095-4dannjjm 2267 15 between between IN cord-023095-4dannjjm 2267 16 a a DT cord-023095-4dannjjm 2267 17 post post JJ cord-023095-4dannjjm 2267 18 - - JJ cord-023095-4dannjjm 2267 19 partum partum JJ cord-023095-4dannjjm 2267 20 and and CC cord-023095-4dannjjm 2267 21 pre pre JJ cord-023095-4dannjjm 2267 22 - - JJ cord-023095-4dannjjm 2267 23 partum partum JJ cord-023095-4dannjjm 2267 24 IMI IMI NNP cord-023095-4dannjjm 2267 25 were be VBD cord-023095-4dannjjm 2267 26 11 11 CD cord-023095-4dannjjm 2267 27 and and CC cord-023095-4dannjjm 2267 28 77 77 CD cord-023095-4dannjjm 2267 29 % % NN cord-023095-4dannjjm 2267 30 , , , cord-023095-4dannjjm 2267 31 43 43 CD cord-023095-4dannjjm 2267 32 and and CC cord-023095-4dannjjm 2267 33 86 86 CD cord-023095-4dannjjm 2267 34 % % NN cord-023095-4dannjjm 2267 35 , , , cord-023095-4dannjjm 2267 36 and and CC cord-023095-4dannjjm 2267 37 12 12 CD cord-023095-4dannjjm 2267 38 and and CC cord-023095-4dannjjm 2267 39 68 68 CD cord-023095-4dannjjm 2267 40 % % NN cord-023095-4dannjjm 2267 41 for for IN cord-023095-4dannjjm 2267 42 all all DT cord-023095-4dannjjm 2267 43 staphylococci staphylococcus NNS cord-023095-4dannjjm 2267 44 , , , cord-023095-4dannjjm 2267 45 S. S. NNP cord-023095-4dannjjm 2267 46 aureus aureus NN cord-023095-4dannjjm 2267 47 only only RB cord-023095-4dannjjm 2267 48 and and CC cord-023095-4dannjjm 2267 49 CNS CNS NNP cord-023095-4dannjjm 2267 50 only only RB cord-023095-4dannjjm 2267 51 IMIs imi NNS cord-023095-4dannjjm 2267 52 , , , cord-023095-4dannjjm 2267 53 respectively respectively RB cord-023095-4dannjjm 2267 54 . . . cord-023095-4dannjjm 2268 1 Mammary mammary JJ cord-023095-4dannjjm 2268 2 quarters quarter NNS cord-023095-4dannjjm 2268 3 sampled sample VBD cord-023095-4dannjjm 2268 4 pre pre JJ cord-023095-4dannjjm 2268 5 - - NNS cord-023095-4dannjjm 2268 6 partum partum NNP cord-023095-4dannjjm 2268 7 were be VBD cord-023095-4dannjjm 2268 8 no no RB cord-023095-4dannjjm 2268 9 more more RBR cord-023095-4dannjjm 2268 10 likely likely JJ cord-023095-4dannjjm 2268 11 to to TO cord-023095-4dannjjm 2268 12 have have VB cord-023095-4dannjjm 2268 13 a a DT cord-023095-4dannjjm 2268 14 post post JJ cord-023095-4dannjjm 2268 15 - - JJ cord-023095-4dannjjm 2268 16 partum partum JJ cord-023095-4dannjjm 2268 17 IMI IMI NNP cord-023095-4dannjjm 2268 18 than than IN cord-023095-4dannjjm 2268 19 those those DT cord-023095-4dannjjm 2268 20 not not RB cord-023095-4dannjjm 2268 21 sampled sample VBN cord-023095-4dannjjm 2268 22 ( ( -LRB- cord-023095-4dannjjm 2268 23 Chisquare Chisquare NNP cord-023095-4dannjjm 2268 24 , , , cord-023095-4dannjjm 2268 25 P p NN cord-023095-4dannjjm 2268 26 ! ! . cord-023095-4dannjjm 2268 27 0.27 0.27 CD cord-023095-4dannjjm 2268 28 ) ) -RRB- cord-023095-4dannjjm 2268 29 . . . cord-023095-4dannjjm 2269 1 These these DT cord-023095-4dannjjm 2269 2 data datum NNS cord-023095-4dannjjm 2269 3 demonstrate demonstrate VBP cord-023095-4dannjjm 2269 4 that that IN cord-023095-4dannjjm 2269 5 pre pre JJ cord-023095-4dannjjm 2269 6 - - JJ cord-023095-4dannjjm 2269 7 partum partum JJ cord-023095-4dannjjm 2269 8 IMIs imi NNS cord-023095-4dannjjm 2269 9 persist persist VBP cord-023095-4dannjjm 2269 10 into into IN cord-023095-4dannjjm 2269 11 early early JJ cord-023095-4dannjjm 2269 12 lactation lactation NN cord-023095-4dannjjm 2269 13 and and CC cord-023095-4dannjjm 2269 14 that that IN cord-023095-4dannjjm 2269 15 pre pre JJ cord-023095-4dannjjm 2269 16 - - JJ cord-023095-4dannjjm 2269 17 partum partum JJ cord-023095-4dannjjm 2269 18 secretion secretion NN cord-023095-4dannjjm 2269 19 cultures culture NNS cord-023095-4dannjjm 2269 20 may may MD cord-023095-4dannjjm 2269 21 be be VB cord-023095-4dannjjm 2269 22 a a DT cord-023095-4dannjjm 2269 23 useful useful JJ cord-023095-4dannjjm 2269 24 , , , cord-023095-4dannjjm 2269 25 not not RB cord-023095-4dannjjm 2269 26 only only RB cord-023095-4dannjjm 2269 27 in in IN cord-023095-4dannjjm 2269 28 predicting predict VBG cord-023095-4dannjjm 2269 29 IMI IMI NNP cord-023095-4dannjjm 2269 30 at at IN cord-023095-4dannjjm 2269 31 calving calving NN cord-023095-4dannjjm 2269 32 , , , cord-023095-4dannjjm 2269 33 but but CC cord-023095-4dannjjm 2269 34 also also RB cord-023095-4dannjjm 2269 35 in in IN cord-023095-4dannjjm 2269 36 assessing assess VBG cord-023095-4dannjjm 2269 37 risk risk NN cord-023095-4dannjjm 2269 38 of of IN cord-023095-4dannjjm 2269 39 introducing introduce VBG cord-023095-4dannjjm 2269 40 new new JJ cord-023095-4dannjjm 2269 41 contagious contagious JJ cord-023095-4dannjjm 2269 42 mastitis mastitis NN cord-023095-4dannjjm 2269 43 pathogens pathogen NNS cord-023095-4dannjjm 2269 44 , , , cord-023095-4dannjjm 2269 45 e.g. e.g. RB cord-023095-4dannjjm 2269 46 , , , cord-023095-4dannjjm 2269 47 S. S. NNP cord-023095-4dannjjm 2269 48 aureus aureus NN cord-023095-4dannjjm 2269 49 , , , cord-023095-4dannjjm 2269 50 into into IN cord-023095-4dannjjm 2269 51 the the DT cord-023095-4dannjjm 2269 52 lactating lactate VBG cord-023095-4dannjjm 2269 53 herd herd NN cord-023095-4dannjjm 2269 54 . . . cord-023095-4dannjjm 2270 1 Despite despite IN cord-023095-4dannjjm 2270 2 concerns concern NNS cord-023095-4dannjjm 2270 3 about about IN cord-023095-4dannjjm 2270 4 antimicrobial antimicrobial JJ cord-023095-4dannjjm 2270 5 resistance resistance NN cord-023095-4dannjjm 2270 6 and and CC cord-023095-4dannjjm 2270 7 Clostridium clostridium NN cord-023095-4dannjjm 2270 8 difficile difficile NN cord-023095-4dannjjm 2270 9 in in IN cord-023095-4dannjjm 2270 10 food food NN cord-023095-4dannjjm 2270 11 animals animal NNS cord-023095-4dannjjm 2270 12 , , , cord-023095-4dannjjm 2270 13 there there EX cord-023095-4dannjjm 2270 14 has have VBZ cord-023095-4dannjjm 2270 15 been be VBN cord-023095-4dannjjm 2270 16 little little JJ cord-023095-4dannjjm 2270 17 study study NN cord-023095-4dannjjm 2270 18 of of IN cord-023095-4dannjjm 2270 19 the the DT cord-023095-4dannjjm 2270 20 prevalence prevalence NN cord-023095-4dannjjm 2270 21 or or CC cord-023095-4dannjjm 2270 22 mechanisms mechanism NNS cord-023095-4dannjjm 2270 23 of of IN cord-023095-4dannjjm 2270 24 resistance resistance NN cord-023095-4dannjjm 2270 25 . . . cord-023095-4dannjjm 2271 1 This this DT cord-023095-4dannjjm 2271 2 study study NN cord-023095-4dannjjm 2271 3 evaluated evaluate VBD cord-023095-4dannjjm 2271 4 the the DT cord-023095-4dannjjm 2271 5 impact impact NN cord-023095-4dannjjm 2271 6 of of IN cord-023095-4dannjjm 2271 7 tetracycline tetracycline NNP cord-023095-4dannjjm 2271 8 treatment treatment NN cord-023095-4dannjjm 2271 9 on on IN cord-023095-4dannjjm 2271 10 C. C. NNP cord-023095-4dannjjm 2271 11 difficile difficile NN cord-023095-4dannjjm 2271 12 shedding shed VBG cord-023095-4dannjjm 2271 13 in in IN cord-023095-4dannjjm 2271 14 veal veal NN cord-023095-4dannjjm 2271 15 calves calf NNS cord-023095-4dannjjm 2271 16 and and CC cord-023095-4dannjjm 2271 17 the the DT cord-023095-4dannjjm 2271 18 impact impact NN cord-023095-4dannjjm 2271 19 on on IN cord-023095-4dannjjm 2271 20 resistance resistance NN cord-023095-4dannjjm 2271 21 . . . cord-023095-4dannjjm 2272 1 Calves calf NNS cord-023095-4dannjjm 2272 2 arriving arrive VBG cord-023095-4dannjjm 2272 3 on on IN cord-023095-4dannjjm 2272 4 1 1 CD cord-023095-4dannjjm 2272 5 veal veal NN cord-023095-4dannjjm 2272 6 farm farm NN cord-023095-4dannjjm 2272 7 received receive VBD cord-023095-4dannjjm 2272 8 oral oral JJ cord-023095-4dannjjm 2272 9 oxytetracycline oxytetracycline NN cord-023095-4dannjjm 2272 10 for for IN cord-023095-4dannjjm 2272 11 5 5 CD cord-023095-4dannjjm 2272 12 days day NNS cord-023095-4dannjjm 2272 13 as as IN cord-023095-4dannjjm 2272 14 per per IN cord-023095-4dannjjm 2272 15 farm farm NN cord-023095-4dannjjm 2272 16 protocols protocol NNS cord-023095-4dannjjm 2272 17 . . . cord-023095-4dannjjm 2273 1 Calves calf NNS cord-023095-4dannjjm 2273 2 were be VBD cord-023095-4dannjjm 2273 3 sampled sample VBN cord-023095-4dannjjm 2273 4 at at IN cord-023095-4dannjjm 2273 5 arrival arrival NN cord-023095-4dannjjm 2273 6 and and CC cord-023095-4dannjjm 2273 7 6 6 CD cord-023095-4dannjjm 2273 8 days day NNS cord-023095-4dannjjm 2273 9 later later RB cord-023095-4dannjjm 2273 10 . . . cord-023095-4dannjjm 2274 1 Selective selective JJ cord-023095-4dannjjm 2274 2 culture culture NN cord-023095-4dannjjm 2274 3 for for IN cord-023095-4dannjjm 2274 4 C. C. NNP cord-023095-4dannjjm 2274 5 difficile difficile NNP cord-023095-4dannjjm 2274 6 was be VBD cord-023095-4dannjjm 2274 7 performed perform VBN cord-023095-4dannjjm 2274 8 . . . cord-023095-4dannjjm 2275 1 Isolates isolate NNS cord-023095-4dannjjm 2275 2 were be VBD cord-023095-4dannjjm 2275 3 ribotyped ribotype VBN cord-023095-4dannjjm 2275 4 , , , cord-023095-4dannjjm 2275 5 and and CC cord-023095-4dannjjm 2275 6 tested test VBN cord-023095-4dannjjm 2275 7 for for IN cord-023095-4dannjjm 2275 8 tetracycline tetracycline NNP cord-023095-4dannjjm 2275 9 susceptibility susceptibility NN cord-023095-4dannjjm 2275 10 and and CC cord-023095-4dannjjm 2275 11 the the DT cord-023095-4dannjjm 2275 12 presence presence NN cord-023095-4dannjjm 2275 13 of of IN cord-023095-4dannjjm 2275 14 tetracycline tetracycline NNP cord-023095-4dannjjm 2275 15 resistance resistance NN cord-023095-4dannjjm 2275 16 genes gene NNS cord-023095-4dannjjm 2275 17 . . . cord-023095-4dannjjm 2276 1 Multivariable multivariable JJ cord-023095-4dannjjm 2276 2 logistic logistic JJ cord-023095-4dannjjm 2276 3 regression regression NN cord-023095-4dannjjm 2276 4 models model NNS cord-023095-4dannjjm 2276 5 were be VBD cord-023095-4dannjjm 2276 6 used use VBN cord-023095-4dannjjm 2276 7 to to TO cord-023095-4dannjjm 2276 8 determine determine VB cord-023095-4dannjjm 2276 9 the the DT cord-023095-4dannjjm 2276 10 relationship relationship NN cord-023095-4dannjjm 2276 11 between between IN cord-023095-4dannjjm 2276 12 tetracycline tetracycline NNP cord-023095-4dannjjm 2276 13 resistance resistance NN cord-023095-4dannjjm 2276 14 and and CC cord-023095-4dannjjm 2276 15 the the DT cord-023095-4dannjjm 2276 16 presence presence NN cord-023095-4dannjjm 2276 17 of of IN cord-023095-4dannjjm 2276 18 tetracycline tetracycline NNP cord-023095-4dannjjm 2276 19 resistance resistance NN cord-023095-4dannjjm 2276 20 genes gene NNS cord-023095-4dannjjm 2276 21 . . . cord-023095-4dannjjm 2277 1 Clostridium clostridium NN cord-023095-4dannjjm 2277 2 difficile difficile NN cord-023095-4dannjjm 2277 3 was be VBD cord-023095-4dannjjm 2277 4 isolated isolate VBN cord-023095-4dannjjm 2277 5 from from IN cord-023095-4dannjjm 2277 6 32 32 CD cord-023095-4dannjjm 2277 7 % % NN cord-023095-4dannjjm 2277 8 ( ( -LRB- cord-023095-4dannjjm 2277 9 56/174 56/174 CD cord-023095-4dannjjm 2277 10 ) ) -RRB- cord-023095-4dannjjm 2277 11 and and CC cord-023095-4dannjjm 2277 12 51 51 CD cord-023095-4dannjjm 2277 13 % % NN cord-023095-4dannjjm 2277 14 ( ( -LRB- cord-023095-4dannjjm 2277 15 88/ 88/ CD cord-023095-4dannjjm 2277 16 172 172 CD cord-023095-4dannjjm 2277 17 ) ) -RRB- cord-023095-4dannjjm 2277 18 calves calf NNS cord-023095-4dannjjm 2277 19 , , , cord-023095-4dannjjm 2277 20 at at IN cord-023095-4dannjjm 2277 21 the the DT cord-023095-4dannjjm 2277 22 first first JJ cord-023095-4dannjjm 2277 23 and and CC cord-023095-4dannjjm 2277 24 second second JJ cord-023095-4dannjjm 2277 25 samples sample NNS cord-023095-4dannjjm 2277 26 , , , cord-023095-4dannjjm 2277 27 respectively respectively RB cord-023095-4dannjjm 2277 28 . . . cord-023095-4dannjjm 2278 1 The the DT cord-023095-4dannjjm 2278 2 percentage percentage NN cord-023095-4dannjjm 2278 3 of of IN cord-023095-4dannjjm 2278 4 tetracycline tetracycline NN cord-023095-4dannjjm 2278 5 resistant resistant JJ cord-023095-4dannjjm 2278 6 isolates isolate NNS cord-023095-4dannjjm 2278 7 increased increase VBD cord-023095-4dannjjm 2278 8 from from IN cord-023095-4dannjjm 2278 9 79 79 CD cord-023095-4dannjjm 2278 10 % % NN cord-023095-4dannjjm 2278 11 to to IN cord-023095-4dannjjm 2278 12 93 93 CD cord-023095-4dannjjm 2278 13 % % NN cord-023095-4dannjjm 2278 14 . . . cord-023095-4dannjjm 2279 1 Isolates isolate NNS cord-023095-4dannjjm 2279 2 from from IN cord-023095-4dannjjm 2279 3 the the DT cord-023095-4dannjjm 2279 4 second second JJ cord-023095-4dannjjm 2279 5 sample sample NN cord-023095-4dannjjm 2279 6 were be VBD cord-023095-4dannjjm 2279 7 3 3 CD cord-023095-4dannjjm 2279 8 times time NNS cord-023095-4dannjjm 2279 9 more more RBR cord-023095-4dannjjm 2279 10 likely likely JJ cord-023095-4dannjjm 2279 11 to to TO cord-023095-4dannjjm 2279 12 be be VB cord-023095-4dannjjm 2279 13 tetracycline tetracycline NN cord-023095-4dannjjm 2279 14 resistant resistant JJ cord-023095-4dannjjm 2279 15 ( ( -LRB- cord-023095-4dannjjm 2279 16 p p NN cord-023095-4dannjjm 2279 17 5 5 CD cord-023095-4dannjjm 2279 18 0.016 0.016 CD cord-023095-4dannjjm 2279 19 ) ) -RRB- cord-023095-4dannjjm 2279 20 and and CC cord-023095-4dannjjm 2279 21 5 5 CD cord-023095-4dannjjm 2279 22 times time NNS cord-023095-4dannjjm 2279 23 more more RBR cord-023095-4dannjjm 2279 24 likely likely JJ cord-023095-4dannjjm 2279 25 to to TO cord-023095-4dannjjm 2279 26 possess possess VB cord-023095-4dannjjm 2279 27 tet(M tet(m ADD cord-023095-4dannjjm 2279 28 ) ) -RRB- cord-023095-4dannjjm 2279 29 ( ( -LRB- cord-023095-4dannjjm 2279 30 p p NN cord-023095-4dannjjm 2279 31 5 5 CD cord-023095-4dannjjm 2279 32 0.004 0.004 CD cord-023095-4dannjjm 2279 33 ) ) -RRB- cord-023095-4dannjjm 2279 34 . . . cord-023095-4dannjjm 2280 1 tet(M tet(M NNP cord-023095-4dannjjm 2280 2 ) ) -RRB- cord-023095-4dannjjm 2280 3 was be VBD cord-023095-4dannjjm 2280 4 detected detect VBN cord-023095-4dannjjm 2280 5 in in IN cord-023095-4dannjjm 2280 6 13 13 CD cord-023095-4dannjjm 2280 7 % % NN cord-023095-4dannjjm 2280 8 ( ( -LRB- cord-023095-4dannjjm 2280 9 7/53 7/53 CD cord-023095-4dannjjm 2280 10 ) ) -RRB- cord-023095-4dannjjm 2280 11 and and CC cord-023095-4dannjjm 2280 12 43 43 CD cord-023095-4dannjjm 2280 13 % % NN cord-023095-4dannjjm 2280 14 ( ( -LRB- cord-023095-4dannjjm 2280 15 39/ 39/ CD cord-023095-4dannjjm 2280 16 91 91 CD cord-023095-4dannjjm 2280 17 ) ) -RRB- cord-023095-4dannjjm 2280 18 , , , cord-023095-4dannjjm 2280 19 tet(O tet(O NNP cord-023095-4dannjjm 2280 20 ) ) -RRB- cord-023095-4dannjjm 2280 21 in in IN cord-023095-4dannjjm 2280 22 23 23 CD cord-023095-4dannjjm 2280 23 % % NN cord-023095-4dannjjm 2280 24 ( ( -LRB- cord-023095-4dannjjm 2280 25 12/53 12/53 CD cord-023095-4dannjjm 2280 26 ) ) -RRB- cord-023095-4dannjjm 2280 27 and and CC cord-023095-4dannjjm 2280 28 19 19 CD cord-023095-4dannjjm 2280 29 % % NN cord-023095-4dannjjm 2280 30 ( ( -LRB- cord-023095-4dannjjm 2280 31 17/91 17/91 CD cord-023095-4dannjjm 2280 32 ) ) -RRB- cord-023095-4dannjjm 2280 33 and and CC cord-023095-4dannjjm 2280 34 tet(W tet(w LS cord-023095-4dannjjm 2280 35 ) ) -RRB- cord-023095-4dannjjm 2280 36 in in IN cord-023095-4dannjjm 2280 37 2 2 CD cord-023095-4dannjjm 2280 38 % % NN cord-023095-4dannjjm 2280 39 ( ( -LRB- cord-023095-4dannjjm 2280 40 1/53 1/53 CD cord-023095-4dannjjm 2280 41 ) ) -RRB- cord-023095-4dannjjm 2280 42 and and CC cord-023095-4dannjjm 2280 43 1 1 CD cord-023095-4dannjjm 2280 44 % % NN cord-023095-4dannjjm 2280 45 ( ( -LRB- cord-023095-4dannjjm 2280 46 1/91 1/91 CD cord-023095-4dannjjm 2280 47 ) ) -RRB- cord-023095-4dannjjm 2280 48 of of IN cord-023095-4dannjjm 2280 49 isolates isolate NNS cord-023095-4dannjjm 2280 50 from from IN cord-023095-4dannjjm 2280 51 first first JJ cord-023095-4dannjjm 2280 52 and and CC cord-023095-4dannjjm 2280 53 second second JJ cord-023095-4dannjjm 2280 54 samples sample NNS cord-023095-4dannjjm 2280 55 , , , cord-023095-4dannjjm 2280 56 respectively respectively RB cord-023095-4dannjjm 2280 57 . . . cord-023095-4dannjjm 2281 1 tet(L tet(L NNP cord-023095-4dannjjm 2281 2 ) ) -RRB- cord-023095-4dannjjm 2281 3 , , , cord-023095-4dannjjm 2281 4 tet(K tet(K NNP cord-023095-4dannjjm 2281 5 ) ) -RRB- cord-023095-4dannjjm 2281 6 and and CC cord-023095-4dannjjm 2281 7 tet(S tet( NNS cord-023095-4dannjjm 2281 8 ) ) -RRB- cord-023095-4dannjjm 2281 9 were be VBD cord-023095-4dannjjm 2281 10 not not RB cord-023095-4dannjjm 2281 11 detected detect VBN cord-023095-4dannjjm 2281 12 . . . cord-023095-4dannjjm 2282 1 54 54 CD cord-023095-4dannjjm 2282 2 resistant resistant JJ cord-023095-4dannjjm 2282 3 isolates isolate NNS cord-023095-4dannjjm 2282 4 were be VBD cord-023095-4dannjjm 2282 5 not not RB cord-023095-4dannjjm 2282 6 carrying carry VBG cord-023095-4dannjjm 2282 7 any any DT cord-023095-4dannjjm 2282 8 of of IN cord-023095-4dannjjm 2282 9 the the DT cord-023095-4dannjjm 2282 10 genes gene NNS cord-023095-4dannjjm 2282 11 investigated investigate VBN cord-023095-4dannjjm 2282 12 . . . cord-023095-4dannjjm 2283 1 Routine routine JJ cord-023095-4dannjjm 2283 2 tetracycline tetracycline NN cord-023095-4dannjjm 2283 3 use use NN cord-023095-4dannjjm 2283 4 may may MD cord-023095-4dannjjm 2283 5 have have VB cord-023095-4dannjjm 2283 6 had have VBN cord-023095-4dannjjm 2283 7 an an DT cord-023095-4dannjjm 2283 8 impact impact NN cord-023095-4dannjjm 2283 9 on on IN cord-023095-4dannjjm 2283 10 both both CC cord-023095-4dannjjm 2283 11 the the DT cord-023095-4dannjjm 2283 12 prevalence prevalence NN cord-023095-4dannjjm 2283 13 of of IN cord-023095-4dannjjm 2283 14 C. C. NNP cord-023095-4dannjjm 2283 15 difficile difficile NNP cord-023095-4dannjjm 2283 16 , , , cord-023095-4dannjjm 2283 17 as as RB cord-023095-4dannjjm 2283 18 well well RB cord-023095-4dannjjm 2283 19 as as IN cord-023095-4dannjjm 2283 20 the the DT cord-023095-4dannjjm 2283 21 strain strain NN cord-023095-4dannjjm 2283 22 distribution distribution NN cord-023095-4dannjjm 2283 23 and and CC cord-023095-4dannjjm 2283 24 resistance resistance NN cord-023095-4dannjjm 2283 25 patterns pattern NNS cord-023095-4dannjjm 2283 26 . . . cord-023095-4dannjjm 2284 1 This this DT cord-023095-4dannjjm 2284 2 is be VBZ cord-023095-4dannjjm 2284 3 the the DT cord-023095-4dannjjm 2284 4 first first JJ cord-023095-4dannjjm 2284 5 report report NN cord-023095-4dannjjm 2284 6 of of IN cord-023095-4dannjjm 2284 7 presence presence NN cord-023095-4dannjjm 2284 8 of of IN cord-023095-4dannjjm 2284 9 tet tet NNP cord-023095-4dannjjm 2284 10 ( ( -LRB- cord-023095-4dannjjm 2284 11 The the DT cord-023095-4dannjjm 2284 12 objectives objective NNS cord-023095-4dannjjm 2284 13 of of IN cord-023095-4dannjjm 2284 14 this this DT cord-023095-4dannjjm 2284 15 study study NN cord-023095-4dannjjm 2284 16 were be VBD cord-023095-4dannjjm 2284 17 to to IN cord-023095-4dannjjm 2284 18 1 1 CD cord-023095-4dannjjm 2284 19 ) ) -RRB- cord-023095-4dannjjm 2284 20 estimate estimate VB cord-023095-4dannjjm 2284 21 the the DT cord-023095-4dannjjm 2284 22 prevalence prevalence NN cord-023095-4dannjjm 2284 23 of of IN cord-023095-4dannjjm 2284 24 antimicrobial antimicrobial JJ cord-023095-4dannjjm 2284 25 resistance resistance NN cord-023095-4dannjjm 2284 26 in in IN cord-023095-4dannjjm 2284 27 the the DT cord-023095-4dannjjm 2284 28 study study NN cord-023095-4dannjjm 2284 29 population population NN cord-023095-4dannjjm 2284 30 and and CC cord-023095-4dannjjm 2284 31 2 2 CD cord-023095-4dannjjm 2284 32 ) ) -RRB- cord-023095-4dannjjm 2284 33 to to TO cord-023095-4dannjjm 2284 34 investigate investigate VB cord-023095-4dannjjm 2284 35 the the DT cord-023095-4dannjjm 2284 36 associations association NNS cord-023095-4dannjjm 2284 37 between between IN cord-023095-4dannjjm 2284 38 exposures exposure NNS cord-023095-4dannjjm 2284 39 to to IN cord-023095-4dannjjm 2284 40 antimicrobial antimicrobial JJ cord-023095-4dannjjm 2284 41 drugs drug NNS cord-023095-4dannjjm 2284 42 and and CC cord-023095-4dannjjm 2284 43 antimicrobial antimicrobial JJ cord-023095-4dannjjm 2284 44 resistance resistance NN cord-023095-4dannjjm 2284 45 in in IN cord-023095-4dannjjm 2284 46 fecal fecal JJ cord-023095-4dannjjm 2284 47 non non JJ cord-023095-4dannjjm 2284 48 - - JJ cord-023095-4dannjjm 2284 49 type type JJ cord-023095-4dannjjm 2284 50 specific specific JJ cord-023095-4dannjjm 2284 51 E. E. NNP cord-023095-4dannjjm 2284 52 coli coli NNS cord-023095-4dannjjm 2284 53 ( ( -LRB- cord-023095-4dannjjm 2284 54 NTSEC NTSEC NNP cord-023095-4dannjjm 2284 55 ) ) -RRB- cord-023095-4dannjjm 2284 56 recovered recover VBD cord-023095-4dannjjm 2284 57 from from IN cord-023095-4dannjjm 2284 58 individual individual JJ cord-023095-4dannjjm 2284 59 feedlot feedlot NN cord-023095-4dannjjm 2284 60 cattle cattle NNS cord-023095-4dannjjm 2284 61 . . . cord-023095-4dannjjm 2285 1 Two two CD cord-023095-4dannjjm 2285 2 - - HYPH cord-023095-4dannjjm 2285 3 stage stage NN cord-023095-4dannjjm 2285 4 random random JJ cord-023095-4dannjjm 2285 5 sampling sampling NN cord-023095-4dannjjm 2285 6 was be VBD cord-023095-4dannjjm 2285 7 used use VBN cord-023095-4dannjjm 2285 8 to to TO cord-023095-4dannjjm 2285 9 identify identify VB cord-023095-4dannjjm 2285 10 cattle cattle NNS cord-023095-4dannjjm 2285 11 for for IN cord-023095-4dannjjm 2285 12 enrollment enrollment NN cord-023095-4dannjjm 2285 13 at at IN cord-023095-4dannjjm 2285 14 4 4 CD cord-023095-4dannjjm 2285 15 western western JJ cord-023095-4dannjjm 2285 16 Canadian canadian JJ cord-023095-4dannjjm 2285 17 feedlots feedlot NNS cord-023095-4dannjjm 2285 18 . . . cord-023095-4dannjjm 2286 1 A a DT cord-023095-4dannjjm 2286 2 fecal fecal JJ cord-023095-4dannjjm 2286 3 sample sample NN cord-023095-4dannjjm 2286 4 was be VBD cord-023095-4dannjjm 2286 5 collected collect VBN cord-023095-4dannjjm 2286 6 per per IN cord-023095-4dannjjm 2286 7 rectum rectum NN cord-023095-4dannjjm 2286 8 from from IN cord-023095-4dannjjm 2286 9 each each DT cord-023095-4dannjjm 2286 10 individual individual NN cord-023095-4dannjjm 2286 11 at at IN cord-023095-4dannjjm 2286 12 arrival arrival NN cord-023095-4dannjjm 2286 13 and and CC cord-023095-4dannjjm 2286 14 in in IN cord-023095-4dannjjm 2286 15 the the DT cord-023095-4dannjjm 2286 16 middle middle NN cord-023095-4dannjjm 2286 17 of of IN cord-023095-4dannjjm 2286 18 the the DT cord-023095-4dannjjm 2286 19 feeding feeding NN cord-023095-4dannjjm 2286 20 period period NN cord-023095-4dannjjm 2286 21 when when WRB cord-023095-4dannjjm 2286 22 cattle cattle NNS cord-023095-4dannjjm 2286 23 were be VBD cord-023095-4dannjjm 2286 24 rehandled rehandle VBN cord-023095-4dannjjm 2286 25 as as IN cord-023095-4dannjjm 2286 26 part part NN cord-023095-4dannjjm 2286 27 of of IN cord-023095-4dannjjm 2286 28 standard standard JJ cord-023095-4dannjjm 2286 29 feedlot feedlot NN cord-023095-4dannjjm 2286 30 protocol protocol NN cord-023095-4dannjjm 2286 31 . . . cord-023095-4dannjjm 2287 1 From from IN cord-023095-4dannjjm 2287 2 samples sample NNS cord-023095-4dannjjm 2287 3 collected collect VBN cord-023095-4dannjjm 2287 4 at at IN cord-023095-4dannjjm 2287 5 this this DT cord-023095-4dannjjm 2287 6 second second JJ cord-023095-4dannjjm 2287 7 time time NN cord-023095-4dannjjm 2287 8 point point NN cord-023095-4dannjjm 2287 9 , , , cord-023095-4dannjjm 2287 10 a a DT cord-023095-4dannjjm 2287 11 total total NN cord-023095-4dannjjm 2287 12 of of IN cord-023095-4dannjjm 2287 13 2,133 2,133 CD cord-023095-4dannjjm 2287 14 NTSEC NTSEC NNP cord-023095-4dannjjm 2287 15 isolates isolate NNS cord-023095-4dannjjm 2287 16 were be VBD cord-023095-4dannjjm 2287 17 tested test VBN cord-023095-4dannjjm 2287 18 for for IN cord-023095-4dannjjm 2287 19 susceptibility susceptibility NN cord-023095-4dannjjm 2287 20 to to IN cord-023095-4dannjjm 2287 21 antimicrobial antimicrobial JJ cord-023095-4dannjjm 2287 22 drugs drug NNS cord-023095-4dannjjm 2287 23 by by IN cord-023095-4dannjjm 2287 24 disk disk NN cord-023095-4dannjjm 2287 25 diffusion diffusion NN cord-023095-4dannjjm 2287 26 . . . cord-023095-4dannjjm 2288 1 Parenteral parenteral JJ cord-023095-4dannjjm 2288 2 and and CC cord-023095-4dannjjm 2288 3 in in IN cord-023095-4dannjjm 2288 4 - - HYPH cord-023095-4dannjjm 2288 5 feed feed NN cord-023095-4dannjjm 2288 6 exposures exposure NNS cord-023095-4dannjjm 2288 7 to to IN cord-023095-4dannjjm 2288 8 antimicrobial antimicrobial JJ cord-023095-4dannjjm 2288 9 drugs drug NNS cord-023095-4dannjjm 2288 10 were be VBD cord-023095-4dannjjm 2288 11 recorded record VBN cord-023095-4dannjjm 2288 12 for for IN cord-023095-4dannjjm 2288 13 each each DT cord-023095-4dannjjm 2288 14 individual individual NN cord-023095-4dannjjm 2288 15 enrolled enrol VBD cord-023095-4dannjjm 2288 16 in in IN cord-023095-4dannjjm 2288 17 the the DT cord-023095-4dannjjm 2288 18 study study NN cord-023095-4dannjjm 2288 19 . . . cord-023095-4dannjjm 2289 1 The the DT cord-023095-4dannjjm 2289 2 least least JJS cord-023095-4dannjjm 2289 3 square square NN cord-023095-4dannjjm 2289 4 means mean NNS cord-023095-4dannjjm 2289 5 estimates estimate NNS cord-023095-4dannjjm 2289 6 and and CC cord-023095-4dannjjm 2289 7 95 95 CD cord-023095-4dannjjm 2289 8 % % NN cord-023095-4dannjjm 2289 9 confidence confidence NN cord-023095-4dannjjm 2289 10 intervals interval NNS cord-023095-4dannjjm 2289 11 for for IN cord-023095-4dannjjm 2289 12 the the DT cord-023095-4dannjjm 2289 13 prevalence prevalence NN cord-023095-4dannjjm 2289 14 of of IN cord-023095-4dannjjm 2289 15 resistance resistance NN cord-023095-4dannjjm 2289 16 at at IN cord-023095-4dannjjm 2289 17 each each DT cord-023095-4dannjjm 2289 18 time time NN cord-023095-4dannjjm 2289 19 point point NN cord-023095-4dannjjm 2289 20 were be VBD cord-023095-4dannjjm 2289 21 modeled model VBN cord-023095-4dannjjm 2289 22 using use VBG cord-023095-4dannjjm 2289 23 Poisson Poisson NNP cord-023095-4dannjjm 2289 24 regression regression NN cord-023095-4dannjjm 2289 25 . . . cord-023095-4dannjjm 2290 1 Multivariable multivariable JJ cord-023095-4dannjjm 2290 2 logistic logistic JJ cord-023095-4dannjjm 2290 3 regression regression NN cord-023095-4dannjjm 2290 4 was be VBD cord-023095-4dannjjm 2290 5 used use VBN cord-023095-4dannjjm 2290 6 to to TO cord-023095-4dannjjm 2290 7 investigate investigate VB cord-023095-4dannjjm 2290 8 associations association NNS cord-023095-4dannjjm 2290 9 between between IN cord-023095-4dannjjm 2290 10 antimicrobial antimicrobial JJ cord-023095-4dannjjm 2290 11 resistance resistance NN cord-023095-4dannjjm 2290 12 and and CC cord-023095-4dannjjm 2290 13 exposure exposure NN cord-023095-4dannjjm 2290 14 to to IN cord-023095-4dannjjm 2290 15 antimicrobial antimicrobial JJ cord-023095-4dannjjm 2290 16 drugs drug NNS cord-023095-4dannjjm 2290 17 . . . cord-023095-4dannjjm 2291 1 Regression regression NN cord-023095-4dannjjm 2291 2 models model NNS cord-023095-4dannjjm 2291 3 were be VBD cord-023095-4dannjjm 2291 4 adjusted adjust VBN cord-023095-4dannjjm 2291 5 for for IN cord-023095-4dannjjm 2291 6 clustering clustering NN cord-023095-4dannjjm 2291 7 of of IN cord-023095-4dannjjm 2291 8 observations observation NNS cord-023095-4dannjjm 2291 9 among among IN cord-023095-4dannjjm 2291 10 individuals individual NNS cord-023095-4dannjjm 2291 11 and and CC cord-023095-4dannjjm 2291 12 pens pen NNS cord-023095-4dannjjm 2291 13 . . . cord-023095-4dannjjm 2292 1 The the DT cord-023095-4dannjjm 2292 2 most most RBS cord-023095-4dannjjm 2292 3 common common JJ cord-023095-4dannjjm 2292 4 resistances resistance NNS cord-023095-4dannjjm 2292 5 identified identify VBN cord-023095-4dannjjm 2292 6 in in IN cord-023095-4dannjjm 2292 7 arrival arrival NN cord-023095-4dannjjm 2292 8 samples sample NNS cord-023095-4dannjjm 2292 9 were be VBD cord-023095-4dannjjm 2292 10 sulfisoxazole sulfisoxazole NNP cord-023095-4dannjjm 2292 11 ( ( -LRB- cord-023095-4dannjjm 2292 12 7.5 7.5 CD cord-023095-4dannjjm 2292 13 % % NN cord-023095-4dannjjm 2292 14 ; ; : cord-023095-4dannjjm 2292 15 95%CI 95%ci CD cord-023095-4dannjjm 2292 16 : : : cord-023095-4dannjjm 2292 17 6.1 6.1 CD cord-023095-4dannjjm 2292 18 - - SYM cord-023095-4dannjjm 2292 19 9.2 9.2 CD cord-023095-4dannjjm 2292 20 ) ) -RRB- cord-023095-4dannjjm 2292 21 , , , cord-023095-4dannjjm 2292 22 streptomycin streptomycin NNS cord-023095-4dannjjm 2292 23 ( ( -LRB- cord-023095-4dannjjm 2292 24 7.7 7.7 CD cord-023095-4dannjjm 2292 25 % % NN cord-023095-4dannjjm 2292 26 ; ; : cord-023095-4dannjjm 2292 27 95%CI 95%ci CD cord-023095-4dannjjm 2292 28 : : : cord-023095-4dannjjm 2292 29 6.3 6.3 CD cord-023095-4dannjjm 2292 30 - - SYM cord-023095-4dannjjm 2292 31 9.5 9.5 CD cord-023095-4dannjjm 2292 32 ) ) -RRB- cord-023095-4dannjjm 2292 33 and and CC cord-023095-4dannjjm 2292 34 tetracycline tetracycline NNP cord-023095-4dannjjm 2292 35 ( ( -LRB- cord-023095-4dannjjm 2292 36 20.0 20.0 CD cord-023095-4dannjjm 2292 37 % % NN cord-023095-4dannjjm 2292 38 ; ; : cord-023095-4dannjjm 2292 39 95%CI 95%ci CD cord-023095-4dannjjm 2292 40 : : : cord-023095-4dannjjm 2292 41 17.7 17.7 CD cord-023095-4dannjjm 2292 42 - - HYPH cord-023095-4dannjjm 2292 43 22.6 22.6 CD cord-023095-4dannjjm 2292 44 ) ) -RRB- cord-023095-4dannjjm 2292 45 . . . cord-023095-4dannjjm 2293 1 At at IN cord-023095-4dannjjm 2293 2 the the DT cord-023095-4dannjjm 2293 3 second second JJ cord-023095-4dannjjm 2293 4 sampling sampling NN cord-023095-4dannjjm 2293 5 point point NN cord-023095-4dannjjm 2293 6 , , , cord-023095-4dannjjm 2293 7 resistance resistance NN cord-023095-4dannjjm 2293 8 prevalence prevalence NN cord-023095-4dannjjm 2293 9 was be VBD cord-023095-4dannjjm 2293 10 25.6 25.6 CD cord-023095-4dannjjm 2293 11 % % NN cord-023095-4dannjjm 2293 12 ( ( -LRB- cord-023095-4dannjjm 2293 13 95%CI 95%ci CD cord-023095-4dannjjm 2293 14 : : : cord-023095-4dannjjm 2293 15 23.5 23.5 CD cord-023095-4dannjjm 2293 16 - - HYPH cord-023095-4dannjjm 2293 17 28.0 28.0 CD cord-023095-4dannjjm 2293 18 ) ) -RRB- cord-023095-4dannjjm 2293 19 for for IN cord-023095-4dannjjm 2293 20 sulfisoxazole sulfisoxazole NNP cord-023095-4dannjjm 2293 21 , , , cord-023095-4dannjjm 2293 22 25.0 25.0 CD cord-023095-4dannjjm 2293 23 % % NN cord-023095-4dannjjm 2293 24 ( ( -LRB- cord-023095-4dannjjm 2293 25 95%CI 95%ci CD cord-023095-4dannjjm 2293 26 : : : cord-023095-4dannjjm 2293 27 22.8 22.8 CD cord-023095-4dannjjm 2293 28 - - HYPH cord-023095-4dannjjm 2293 29 27.3 27.3 CD cord-023095-4dannjjm 2293 30 ) ) -RRB- cord-023095-4dannjjm 2293 31 for for IN cord-023095-4dannjjm 2293 32 streptomycin streptomycin NNS cord-023095-4dannjjm 2293 33 , , , cord-023095-4dannjjm 2293 34 and and CC cord-023095-4dannjjm 2293 35 72.7 72.7 CD cord-023095-4dannjjm 2293 36 % % NN cord-023095-4dannjjm 2293 37 ( ( -LRB- cord-023095-4dannjjm 2293 38 95%CI 95%ci CD cord-023095-4dannjjm 2293 39 : : : cord-023095-4dannjjm 2293 40 70.5 70.5 CD cord-023095-4dannjjm 2293 41 - - HYPH cord-023095-4dannjjm 2293 42 75.1 75.1 CD cord-023095-4dannjjm 2293 43 ) ) -RRB- cord-023095-4dannjjm 2293 44 for for IN cord-023095-4dannjjm 2293 45 tetracycline tetracycline NNP cord-023095-4dannjjm 2293 46 . . . cord-023095-4dannjjm 2294 1 Logistic logistic JJ cord-023095-4dannjjm 2294 2 regression regression NN cord-023095-4dannjjm 2294 3 modeling modeling NN cord-023095-4dannjjm 2294 4 identified identify VBD cord-023095-4dannjjm 2294 5 weak weak JJ cord-023095-4dannjjm 2294 6 associations association NNS cord-023095-4dannjjm 2294 7 of of IN cord-023095-4dannjjm 2294 8 exposures exposure NNS cord-023095-4dannjjm 2294 9 to to IN cord-023095-4dannjjm 2294 10 tetracycline tetracycline NNP cord-023095-4dannjjm 2294 11 and and CC cord-023095-4dannjjm 2294 12 macrolide macrolide NN cord-023095-4dannjjm 2294 13 classes class NNS cord-023095-4dannjjm 2294 14 of of IN cord-023095-4dannjjm 2294 15 drugs drug NNS cord-023095-4dannjjm 2294 16 with with IN cord-023095-4dannjjm 2294 17 antimicrobial antimicrobial JJ cord-023095-4dannjjm 2294 18 resistance resistance NN cord-023095-4dannjjm 2294 19 at at IN cord-023095-4dannjjm 2294 20 the the DT cord-023095-4dannjjm 2294 21 second second JJ cord-023095-4dannjjm 2294 22 time time NN cord-023095-4dannjjm 2294 23 point point NN cord-023095-4dannjjm 2294 24 . . . cord-023095-4dannjjm 2295 1 ABSTRACT ABSTRACT NNP cord-023095-4dannjjm 2295 2 FA-5 FA-5 NNP cord-023095-4dannjjm 2296 1 PREMATURE premature JJ cord-023095-4dannjjm 2296 2 / / SYM cord-023095-4dannjjm 2296 3 DYSMATURE DYSMATURE NNP cord-023095-4dannjjm 2296 4 SYNDROME syndrome NN cord-023095-4dannjjm 2296 5 IN in IN cord-023095-4dannjjm 2296 6 CRIA cria NN cord-023095-4dannjjm 2296 7 : : : cord-023095-4dannjjm 2297 1 A a DT cord-023095-4dannjjm 2297 2 RET ret NN cord-023095-4dannjjm 2297 3 - - HYPH cord-023095-4dannjjm 2297 4 ROSPECTIVE ROSPECTIVE NNP cord-023095-4dannjjm 2297 5 STUDY study NN cord-023095-4dannjjm 2297 6 OF of IN cord-023095-4dannjjm 2297 7 63 63 CD cord-023095-4dannjjm 2297 8 CASES case NNS cord-023095-4dannjjm 2297 9 ( ( -LRB- cord-023095-4dannjjm 2297 10 1999 1999 CD cord-023095-4dannjjm 2297 11 ) ) -RRB- cord-023095-4dannjjm 2297 12 ( ( -LRB- cord-023095-4dannjjm 2297 13 2000 2000 CD cord-023095-4dannjjm 2297 14 ) ) -RRB- cord-023095-4dannjjm 2297 15 ( ( -LRB- cord-023095-4dannjjm 2297 16 2001 2001 CD cord-023095-4dannjjm 2297 17 ) ) -RRB- cord-023095-4dannjjm 2297 18 ( ( -LRB- cord-023095-4dannjjm 2297 19 2002 2002 CD cord-023095-4dannjjm 2297 20 ) ) -RRB- cord-023095-4dannjjm 2297 21 ( ( -LRB- cord-023095-4dannjjm 2297 22 2003 2003 CD cord-023095-4dannjjm 2297 23 ) ) -RRB- cord-023095-4dannjjm 2297 24 ( ( -LRB- cord-023095-4dannjjm 2297 25 2004 2004 CD cord-023095-4dannjjm 2297 26 ) ) -RRB- cord-023095-4dannjjm 2297 27 ( ( -LRB- cord-023095-4dannjjm 2297 28 2005 2005 CD cord-023095-4dannjjm 2297 29 ) ) -RRB- cord-023095-4dannjjm 2297 30 . . . cord-023095-4dannjjm 2298 1 C. C. NNP cord-023095-4dannjjm 2298 2 Gerspach Gerspach NNP cord-023095-4dannjjm 2298 3 , , , cord-023095-4dannjjm 2298 4 D. D. NNP cord-023095-4dannjjm 2298 5 Anderson Anderson NNP cord-023095-4dannjjm 2298 6 . . . cord-023095-4dannjjm 2299 1 The the DT cord-023095-4dannjjm 2299 2 Ohio Ohio NNP cord-023095-4dannjjm 2299 3 State State NNP cord-023095-4dannjjm 2299 4 University University NNP cord-023095-4dannjjm 2299 5 , , , cord-023095-4dannjjm 2299 6 Columbus Columbus NNP cord-023095-4dannjjm 2299 7 OH OH NNP cord-023095-4dannjjm 2299 8 . . . cord-023095-4dannjjm 2300 1 Prematurity prematurity NN cord-023095-4dannjjm 2300 2 is be VBZ cord-023095-4dannjjm 2300 3 widely widely RB cord-023095-4dannjjm 2300 4 acknowledged acknowledge VBN cord-023095-4dannjjm 2300 5 as as IN cord-023095-4dannjjm 2300 6 risk risk NN cord-023095-4dannjjm 2300 7 factor factor NN cord-023095-4dannjjm 2300 8 for for IN cord-023095-4dannjjm 2300 9 subsequent subsequent JJ cord-023095-4dannjjm 2300 10 morbidity morbidity NN cord-023095-4dannjjm 2300 11 and and CC cord-023095-4dannjjm 2300 12 mortality mortality NN cord-023095-4dannjjm 2300 13 in in IN cord-023095-4dannjjm 2300 14 llama llama NN cord-023095-4dannjjm 2300 15 and and CC cord-023095-4dannjjm 2300 16 alpaca alpaca NN cord-023095-4dannjjm 2300 17 cria cria NN cord-023095-4dannjjm 2300 18 . . . cord-023095-4dannjjm 2301 1 A a DT cord-023095-4dannjjm 2301 2 review review NN cord-023095-4dannjjm 2301 3 of of IN cord-023095-4dannjjm 2301 4 medical medical JJ cord-023095-4dannjjm 2301 5 records record NNS cord-023095-4dannjjm 2301 6 for for IN cord-023095-4dannjjm 2301 7 premature premature JJ cord-023095-4dannjjm 2301 8 cria cria NN cord-023095-4dannjjm 2301 9 alive alive JJ cord-023095-4dannjjm 2301 10 at at IN cord-023095-4dannjjm 2301 11 the the DT cord-023095-4dannjjm 2301 12 time time NN cord-023095-4dannjjm 2301 13 of of IN cord-023095-4dannjjm 2301 14 admission admission NN cord-023095-4dannjjm 2301 15 to to IN cord-023095-4dannjjm 2301 16 the the DT cord-023095-4dannjjm 2301 17 Veterinary Veterinary NNP cord-023095-4dannjjm 2301 18 Teaching Teaching NNP cord-023095-4dannjjm 2301 19 Hospital Hospital NNP cord-023095-4dannjjm 2301 20 between between IN cord-023095-4dannjjm 2301 21 1999 1999 CD cord-023095-4dannjjm 2301 22 and and CC cord-023095-4dannjjm 2301 23 2005 2005 CD cord-023095-4dannjjm 2301 24 was be VBD cord-023095-4dannjjm 2301 25 performed perform VBN cord-023095-4dannjjm 2301 26 to to TO cord-023095-4dannjjm 2301 27 determine determine VB cord-023095-4dannjjm 2301 28 risk risk NN cord-023095-4dannjjm 2301 29 factors factor NNS cord-023095-4dannjjm 2301 30 of of IN cord-023095-4dannjjm 2301 31 prematurity prematurity NN cord-023095-4dannjjm 2301 32 and and CC cord-023095-4dannjjm 2301 33 to to TO cord-023095-4dannjjm 2301 34 report report VB cord-023095-4dannjjm 2301 35 the the DT cord-023095-4dannjjm 2301 36 outcome outcome NN cord-023095-4dannjjm 2301 37 and and CC cord-023095-4dannjjm 2301 38 related related JJ cord-023095-4dannjjm 2301 39 conditions condition NNS cord-023095-4dannjjm 2301 40 or or CC cord-023095-4dannjjm 2301 41 diseases disease NNS cord-023095-4dannjjm 2301 42 in in IN cord-023095-4dannjjm 2301 43 affected affected JJ cord-023095-4dannjjm 2301 44 cria cria NN cord-023095-4dannjjm 2301 45 . . . cord-023095-4dannjjm 2302 1 Medical medical JJ cord-023095-4dannjjm 2302 2 records record NNS cord-023095-4dannjjm 2302 3 for for IN cord-023095-4dannjjm 2302 4 63 63 CD cord-023095-4dannjjm 2303 1 premature premature JJ cord-023095-4dannjjm 2303 2 or or CC cord-023095-4dannjjm 2303 3 dysmature dysmature NN cord-023095-4dannjjm 2303 4 cria cria NN cord-023095-4dannjjm 2303 5 were be VBD cord-023095-4dannjjm 2303 6 included include VBN cord-023095-4dannjjm 2303 7 in in IN cord-023095-4dannjjm 2303 8 this this DT cord-023095-4dannjjm 2303 9 study study NN cord-023095-4dannjjm 2303 10 . . . cord-023095-4dannjjm 2304 1 Of of IN cord-023095-4dannjjm 2304 2 these these DT cord-023095-4dannjjm 2304 3 cria cria NN cord-023095-4dannjjm 2304 4 , , , cord-023095-4dannjjm 2304 5 51 51 CD cord-023095-4dannjjm 2304 6 were be VBD cord-023095-4dannjjm 2304 7 alpaca alpaca NN cord-023095-4dannjjm 2304 8 and and CC cord-023095-4dannjjm 2304 9 12 12 CD cord-023095-4dannjjm 2304 10 llama llama NN cord-023095-4dannjjm 2304 11 , , , cord-023095-4dannjjm 2304 12 36 36 CD cord-023095-4dannjjm 2304 13 were be VBD cord-023095-4dannjjm 2304 14 female female JJ cord-023095-4dannjjm 2304 15 and and CC cord-023095-4dannjjm 2304 16 27 27 CD cord-023095-4dannjjm 2304 17 were be VBD cord-023095-4dannjjm 2304 18 male male JJ cord-023095-4dannjjm 2304 19 . . . cord-023095-4dannjjm 2305 1 Reasons reason NNS cord-023095-4dannjjm 2305 2 for for IN cord-023095-4dannjjm 2305 3 referral referral NN cord-023095-4dannjjm 2305 4 were be VBD cord-023095-4dannjjm 2305 5 prematurity prematurity NN cord-023095-4dannjjm 2305 6 , , , cord-023095-4dannjjm 2305 7 failure failure NN cord-023095-4dannjjm 2305 8 of of IN cord-023095-4dannjjm 2305 9 passive passive JJ cord-023095-4dannjjm 2305 10 immunity immunity NN cord-023095-4dannjjm 2305 11 , , , cord-023095-4dannjjm 2305 12 dyspnoea dyspnoea NNS cord-023095-4dannjjm 2305 13 , , , cord-023095-4dannjjm 2305 14 weakness weakness NN cord-023095-4dannjjm 2305 15 and and CC cord-023095-4dannjjm 2305 16 failure failure NN cord-023095-4dannjjm 2305 17 to to TO cord-023095-4dannjjm 2305 18 gain gain VB cord-023095-4dannjjm 2305 19 weight weight NN cord-023095-4dannjjm 2305 20 . . . cord-023095-4dannjjm 2306 1 Cria Cria NNP cord-023095-4dannjjm 2306 2 were be VBD cord-023095-4dannjjm 2306 3 presented present VBN cord-023095-4dannjjm 2306 4 at at IN cord-023095-4dannjjm 2306 5 a a DT cord-023095-4dannjjm 2306 6 mean mean JJ cord-023095-4dannjjm 2306 7 age age NN cord-023095-4dannjjm 2306 8 of of IN cord-023095-4dannjjm 2306 9 1.4 1.4 CD cord-023095-4dannjjm 2306 10 days day NNS cord-023095-4dannjjm 2306 11 and and CC cord-023095-4dannjjm 2306 12 were be VBD cord-023095-4dannjjm 2306 13 premature premature JJ cord-023095-4dannjjm 2306 14 by by IN cord-023095-4dannjjm 2306 15 a a DT cord-023095-4dannjjm 2306 16 mean mean JJ cord-023095-4dannjjm 2306 17 estimated estimate VBN cord-023095-4dannjjm 2306 18 time time NN cord-023095-4dannjjm 2306 19 of of IN cord-023095-4dannjjm 2306 20 19.5 19.5 CD cord-023095-4dannjjm 2306 21 days day NNS cord-023095-4dannjjm 2306 22 . . . cord-023095-4dannjjm 2307 1 Overall overall JJ cord-023095-4dannjjm 2307 2 survival survival NN cord-023095-4dannjjm 2307 3 rate rate NN cord-023095-4dannjjm 2307 4 was be VBD cord-023095-4dannjjm 2307 5 82.5 82.5 CD cord-023095-4dannjjm 2307 6 % % NN cord-023095-4dannjjm 2307 7 , , , cord-023095-4dannjjm 2307 8 with with IN cord-023095-4dannjjm 2307 9 all all DT cord-023095-4dannjjm 2307 10 llama llama NN cord-023095-4dannjjm 2307 11 cria cria NN cord-023095-4dannjjm 2307 12 surviving survive VBG cord-023095-4dannjjm 2307 13 . . . cord-023095-4dannjjm 2308 1 A a DT cord-023095-4dannjjm 2308 2 multivariate multivariate JJ cord-023095-4dannjjm 2308 3 logistic logistic JJ cord-023095-4dannjjm 2308 4 regression regression NN cord-023095-4dannjjm 2308 5 model model NN cord-023095-4dannjjm 2308 6 was be VBD cord-023095-4dannjjm 2308 7 used use VBN cord-023095-4dannjjm 2308 8 to to TO cord-023095-4dannjjm 2308 9 identify identify VB cord-023095-4dannjjm 2308 10 risk risk NN cord-023095-4dannjjm 2308 11 factors factor NNS cord-023095-4dannjjm 2308 12 associated associate VBN cord-023095-4dannjjm 2308 13 with with IN cord-023095-4dannjjm 2308 14 not not RB cord-023095-4dannjjm 2308 15 surviving survive VBG cord-023095-4dannjjm 2308 16 . . . cord-023095-4dannjjm 2309 1 Cria cria NN cord-023095-4dannjjm 2309 2 receiving receive VBG cord-023095-4dannjjm 2309 3 camelid camelid NNP cord-023095-4dannjjm 2309 4 colostrum colostrum NN cord-023095-4dannjjm 2309 5 had have VBD cord-023095-4dannjjm 2309 6 a a DT cord-023095-4dannjjm 2309 7 significant significant JJ cord-023095-4dannjjm 2309 8 better well JJR cord-023095-4dannjjm 2309 9 outcome outcome NN cord-023095-4dannjjm 2309 10 than than IN cord-023095-4dannjjm 2309 11 cria cria NN cord-023095-4dannjjm 2309 12 receiving receive VBG cord-023095-4dannjjm 2309 13 no no DT cord-023095-4dannjjm 2309 14 colostrum colostrum NN cord-023095-4dannjjm 2309 15 or or CC cord-023095-4dannjjm 2309 16 colostrum colostrum NN cord-023095-4dannjjm 2309 17 from from IN cord-023095-4dannjjm 2309 18 different different JJ cord-023095-4dannjjm 2309 19 species specie NNS cord-023095-4dannjjm 2309 20 . . . cord-023095-4dannjjm 2310 1 Dyspnea Dyspnea NNP cord-023095-4dannjjm 2310 2 and and CC cord-023095-4dannjjm 2310 3 tachypnea tachypnea NNP cord-023095-4dannjjm 2310 4 was be VBD cord-023095-4dannjjm 2310 5 associated associate VBN cord-023095-4dannjjm 2310 6 with with IN cord-023095-4dannjjm 2310 7 a a DT cord-023095-4dannjjm 2310 8 poor poor JJ cord-023095-4dannjjm 2310 9 outcome outcome NN cord-023095-4dannjjm 2310 10 . . . cord-023095-4dannjjm 2311 1 All all DT cord-023095-4dannjjm 2311 2 cria cria NN cord-023095-4dannjjm 2311 3 that that WDT cord-023095-4dannjjm 2311 4 were be VBD cord-023095-4dannjjm 2311 5 able able JJ cord-023095-4dannjjm 2311 6 to to TO cord-023095-4dannjjm 2311 7 nurse nurse VB cord-023095-4dannjjm 2311 8 , , , cord-023095-4dannjjm 2311 9 without without IN cord-023095-4dannjjm 2311 10 assistance assistance NN cord-023095-4dannjjm 2311 11 prior prior RB cord-023095-4dannjjm 2311 12 to to IN cord-023095-4dannjjm 2311 13 referral referral NN cord-023095-4dannjjm 2311 14 , , , cord-023095-4dannjjm 2311 15 survived survive VBD cord-023095-4dannjjm 2311 16 . . . cord-023095-4dannjjm 2312 1 Clinical clinical JJ cord-023095-4dannjjm 2312 2 pathology pathology NN cord-023095-4dannjjm 2312 3 parameters parameter NNS cord-023095-4dannjjm 2312 4 most most RBS cord-023095-4dannjjm 2312 5 commonly commonly RB cord-023095-4dannjjm 2312 6 associated associate VBN cord-023095-4dannjjm 2312 7 with with IN cord-023095-4dannjjm 2312 8 death death NN cord-023095-4dannjjm 2312 9 were be VBD cord-023095-4dannjjm 2312 10 hyperphosphatemia hyperphosphatemia NN cord-023095-4dannjjm 2312 11 and and CC cord-023095-4dannjjm 2312 12 acidosis acidosis NN cord-023095-4dannjjm 2312 13 . . . cord-023095-4dannjjm 2313 1 Enrofloxacin Enrofloxacin NNP cord-023095-4dannjjm 2313 2 is be VBZ cord-023095-4dannjjm 2313 3 approved approve VBN cord-023095-4dannjjm 2313 4 for for IN cord-023095-4dannjjm 2313 5 the the DT cord-023095-4dannjjm 2313 6 treatment treatment NN cord-023095-4dannjjm 2313 7 of of IN cord-023095-4dannjjm 2313 8 swine swine NN cord-023095-4dannjjm 2313 9 respiratory respiratory JJ cord-023095-4dannjjm 2313 10 disease disease NN cord-023095-4dannjjm 2313 11 , , , cord-023095-4dannjjm 2313 12 however however RB cord-023095-4dannjjm 2313 13 there there EX cord-023095-4dannjjm 2313 14 are be VBP cord-023095-4dannjjm 2313 15 no no DT cord-023095-4dannjjm 2313 16 published publish VBN cord-023095-4dannjjm 2313 17 studies study NNS cord-023095-4dannjjm 2313 18 describing describe VBG cord-023095-4dannjjm 2313 19 the the DT cord-023095-4dannjjm 2313 20 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 2313 21 of of IN cord-023095-4dannjjm 2313 22 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 2313 23 at at IN cord-023095-4dannjjm 2313 24 the the DT cord-023095-4dannjjm 2313 25 approved approve VBN cord-023095-4dannjjm 2313 26 dose dose NN cord-023095-4dannjjm 2313 27 and and CC cord-023095-4dannjjm 2313 28 route route NN cord-023095-4dannjjm 2313 29 in in IN cord-023095-4dannjjm 2313 30 pigs pig NNS cord-023095-4dannjjm 2313 31 ( ( -LRB- cord-023095-4dannjjm 2313 32 7.5 7.5 CD cord-023095-4dannjjm 2313 33 mg mg NNP cord-023095-4dannjjm 2313 34 / / SYM cord-023095-4dannjjm 2313 35 kg kg NNP cord-023095-4dannjjm 2313 36 subcutaneously subcutaneously RB cord-023095-4dannjjm 2313 37 ) ) -RRB- cord-023095-4dannjjm 2313 38 . . . cord-023095-4dannjjm 2314 1 Furthermore furthermore RB cord-023095-4dannjjm 2314 2 no no DT cord-023095-4dannjjm 2314 3 studies study NNS cord-023095-4dannjjm 2314 4 have have VBP cord-023095-4dannjjm 2314 5 assessed assess VBN cord-023095-4dannjjm 2314 6 the the DT cord-023095-4dannjjm 2314 7 unbound unbound JJ cord-023095-4dannjjm 2314 8 concentrations concentration NNS cord-023095-4dannjjm 2314 9 of of IN cord-023095-4dannjjm 2314 10 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 2314 11 at at IN cord-023095-4dannjjm 2314 12 its -PRON- PRP$ cord-023095-4dannjjm 2314 13 site site NN cord-023095-4dannjjm 2314 14 of of IN cord-023095-4dannjjm 2314 15 action action NN cord-023095-4dannjjm 2314 16 , , , cord-023095-4dannjjm 2314 17 the the DT cord-023095-4dannjjm 2314 18 extracellular extracellular JJ cord-023095-4dannjjm 2314 19 tissue tissue NN cord-023095-4dannjjm 2314 20 fluid fluid NN cord-023095-4dannjjm 2314 21 . . . cord-023095-4dannjjm 2315 1 Therefore therefore RB cord-023095-4dannjjm 2315 2 the the DT cord-023095-4dannjjm 2315 3 objective objective NN cord-023095-4dannjjm 2315 4 of of IN cord-023095-4dannjjm 2315 5 this this DT cord-023095-4dannjjm 2315 6 study study NN cord-023095-4dannjjm 2315 7 was be VBD cord-023095-4dannjjm 2315 8 to to TO cord-023095-4dannjjm 2315 9 use use VB cord-023095-4dannjjm 2315 10 an an DT cord-023095-4dannjjm 2315 11 in in IN cord-023095-4dannjjm 2315 12 - - HYPH cord-023095-4dannjjm 2315 13 vivo vivo NN cord-023095-4dannjjm 2315 14 ultrafiltration ultrafiltration NN cord-023095-4dannjjm 2315 15 method method NN cord-023095-4dannjjm 2315 16 to to TO cord-023095-4dannjjm 2315 17 measure measure VB cord-023095-4dannjjm 2315 18 the the DT cord-023095-4dannjjm 2315 19 active active JJ cord-023095-4dannjjm 2315 20 fraction fraction NN cord-023095-4dannjjm 2315 21 of of IN cord-023095-4dannjjm 2315 22 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 2315 23 , , , cord-023095-4dannjjm 2315 24 and and CC cord-023095-4dannjjm 2315 25 the the DT cord-023095-4dannjjm 2315 26 metabolite metabolite JJ cord-023095-4dannjjm 2315 27 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 2315 28 , , , cord-023095-4dannjjm 2315 29 at at IN cord-023095-4dannjjm 2315 30 3 3 CD cord-023095-4dannjjm 2315 31 tissue tissue NN cord-023095-4dannjjm 2315 32 sites site NNS cord-023095-4dannjjm 2315 33 relevant relevant JJ cord-023095-4dannjjm 2315 34 to to IN cord-023095-4dannjjm 2315 35 pigs pig NNS cord-023095-4dannjjm 2315 36 , , , cord-023095-4dannjjm 2315 37 and and CC cord-023095-4dannjjm 2315 38 to to TO cord-023095-4dannjjm 2315 39 compare compare VB cord-023095-4dannjjm 2315 40 these these DT cord-023095-4dannjjm 2315 41 concentrations concentration NNS cord-023095-4dannjjm 2315 42 with with IN cord-023095-4dannjjm 2315 43 plasma plasma NN cord-023095-4dannjjm 2315 44 concentrations concentration NNS cord-023095-4dannjjm 2315 45 collected collect VBN cord-023095-4dannjjm 2315 46 at at IN cord-023095-4dannjjm 2315 47 similar similar JJ cord-023095-4dannjjm 2315 48 time time NN cord-023095-4dannjjm 2315 49 points point NNS cord-023095-4dannjjm 2315 50 . . . cord-023095-4dannjjm 2316 1 Six six CD cord-023095-4dannjjm 2316 2 healthy healthy JJ cord-023095-4dannjjm 2316 3 pigs pig NNS cord-023095-4dannjjm 2316 4 were be VBD cord-023095-4dannjjm 2316 5 used use VBN cord-023095-4dannjjm 2316 6 in in IN cord-023095-4dannjjm 2316 7 this this DT cord-023095-4dannjjm 2316 8 study study NN cord-023095-4dannjjm 2316 9 . . . cord-023095-4dannjjm 2317 1 Pigs pig NNS cord-023095-4dannjjm 2317 2 were be VBD cord-023095-4dannjjm 2317 3 recently recently RB cord-023095-4dannjjm 2317 4 weaned wean VBN cord-023095-4dannjjm 2317 5 and and CC cord-023095-4dannjjm 2317 6 weighed weigh VBD cord-023095-4dannjjm 2317 7 an an DT cord-023095-4dannjjm 2317 8 average average JJ cord-023095-4dannjjm 2317 9 16.3 16.3 CD cord-023095-4dannjjm 2317 10 kg kg NNS cord-023095-4dannjjm 2317 11 . . . cord-023095-4dannjjm 2318 1 On on IN cord-023095-4dannjjm 2318 2 the the DT cord-023095-4dannjjm 2318 3 day day NN cord-023095-4dannjjm 2318 4 before before IN cord-023095-4dannjjm 2318 5 the the DT cord-023095-4dannjjm 2318 6 experiment experiment NN cord-023095-4dannjjm 2318 7 , , , cord-023095-4dannjjm 2318 8 pigs pig NNS cord-023095-4dannjjm 2318 9 were be VBD cord-023095-4dannjjm 2318 10 anesthetized anesthetize VBN cord-023095-4dannjjm 2318 11 for for IN cord-023095-4dannjjm 2318 12 the the DT cord-023095-4dannjjm 2318 13 placement placement NN cord-023095-4dannjjm 2318 14 of of IN cord-023095-4dannjjm 2318 15 jugular jugular NNP cord-023095-4dannjjm 2318 16 vein vein NN cord-023095-4dannjjm 2318 17 sampling sampling NN cord-023095-4dannjjm 2318 18 catheters catheter NNS cord-023095-4dannjjm 2318 19 and and CC cord-023095-4dannjjm 2318 20 interstitial interstitial JJ cord-023095-4dannjjm 2318 21 fluid fluid JJ cord-023095-4dannjjm 2318 22 collection collection NN cord-023095-4dannjjm 2318 23 probes probe NNS cord-023095-4dannjjm 2318 24 . . . cord-023095-4dannjjm 2319 1 Three three CD cord-023095-4dannjjm 2319 2 ultrafiltration ultrafiltration NN cord-023095-4dannjjm 2319 3 probes probe NNS cord-023095-4dannjjm 2319 4 were be VBD cord-023095-4dannjjm 2319 5 placed place VBN cord-023095-4dannjjm 2319 6 in in IN cord-023095-4dannjjm 2319 7 each each DT cord-023095-4dannjjm 2319 8 pig pig NN cord-023095-4dannjjm 2319 9 in in IN cord-023095-4dannjjm 2319 10 a a DT cord-023095-4dannjjm 2319 11 subcutaneous subcutaneous JJ cord-023095-4dannjjm 2319 12 site site NN cord-023095-4dannjjm 2319 13 near near IN cord-023095-4dannjjm 2319 14 the the DT cord-023095-4dannjjm 2319 15 right right JJ cord-023095-4dannjjm 2319 16 shoulder shoulder NN cord-023095-4dannjjm 2319 17 , , , cord-023095-4dannjjm 2319 18 an an DT cord-023095-4dannjjm 2319 19 intramuscular intramuscular JJ cord-023095-4dannjjm 2319 20 site site NN cord-023095-4dannjjm 2319 21 along along IN cord-023095-4dannjjm 2319 22 the the DT cord-023095-4dannjjm 2319 23 epaxial epaxial JJ cord-023095-4dannjjm 2319 24 muscles muscle NNS cord-023095-4dannjjm 2319 25 , , , cord-023095-4dannjjm 2319 26 and and CC cord-023095-4dannjjm 2319 27 in in IN cord-023095-4dannjjm 2319 28 the the DT cord-023095-4dannjjm 2319 29 pleural pleural JJ cord-023095-4dannjjm 2319 30 space space NN cord-023095-4dannjjm 2319 31 of of IN cord-023095-4dannjjm 2319 32 the the DT cord-023095-4dannjjm 2319 33 chest chest NN cord-023095-4dannjjm 2319 34 cavity cavity NN cord-023095-4dannjjm 2319 35 . . . cord-023095-4dannjjm 2320 1 Each each DT cord-023095-4dannjjm 2320 2 pig pig NN cord-023095-4dannjjm 2320 3 received receive VBD cord-023095-4dannjjm 2320 4 an an DT cord-023095-4dannjjm 2320 5 injection injection NN cord-023095-4dannjjm 2320 6 of of IN cord-023095-4dannjjm 2320 7 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 2320 8 ( ( -LRB- cord-023095-4dannjjm 2320 9 Baytril Baytril NNP cord-023095-4dannjjm 2320 10 100 100 CD cord-023095-4dannjjm 2320 11 , , , cord-023095-4dannjjm 2320 12 Bayer Bayer NNP cord-023095-4dannjjm 2320 13 Animal Animal NNP cord-023095-4dannjjm 2320 14 Health Health NNP cord-023095-4dannjjm 2320 15 ) ) -RRB- cord-023095-4dannjjm 2320 16 at at IN cord-023095-4dannjjm 2320 17 a a DT cord-023095-4dannjjm 2320 18 dose dose NN cord-023095-4dannjjm 2320 19 of of IN cord-023095-4dannjjm 2320 20 7.5 7.5 CD cord-023095-4dannjjm 2320 21 mg/ mg/ NN cord-023095-4dannjjm 2320 22 kg kg NNP cord-023095-4dannjjm 2320 23 subcutaneously subcutaneously RB cord-023095-4dannjjm 2320 24 behind behind IN cord-023095-4dannjjm 2320 25 the the DT cord-023095-4dannjjm 2320 26 left left JJ cord-023095-4dannjjm 2320 27 ear ear NN cord-023095-4dannjjm 2320 28 . . . cord-023095-4dannjjm 2321 1 Plasma plasma NN cord-023095-4dannjjm 2321 2 and and CC cord-023095-4dannjjm 2321 3 interstitial interstitial JJ cord-023095-4dannjjm 2321 4 fluid fluid NN cord-023095-4dannjjm 2321 5 samples sample NNS cord-023095-4dannjjm 2321 6 were be VBD cord-023095-4dannjjm 2321 7 collected collect VBN cord-023095-4dannjjm 2321 8 at at IN cord-023095-4dannjjm 2321 9 pre pre JJ cord-023095-4dannjjm 2321 10 - - JJ cord-023095-4dannjjm 2321 11 determined determined JJ cord-023095-4dannjjm 2321 12 time time NN cord-023095-4dannjjm 2321 13 points point NNS cord-023095-4dannjjm 2321 14 , , , cord-023095-4dannjjm 2321 15 and and CC cord-023095-4dannjjm 2321 16 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 2321 17 and and CC cord-023095-4dannjjm 2321 18 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 2321 19 concentrations concentration NNS cord-023095-4dannjjm 2321 20 were be VBD cord-023095-4dannjjm 2321 21 measured measure VBN cord-023095-4dannjjm 2321 22 using use VBG cord-023095-4dannjjm 2321 23 HPLC HPLC NNP cord-023095-4dannjjm 2321 24 with with IN cord-023095-4dannjjm 2321 25 fluorescence fluorescence NN cord-023095-4dannjjm 2321 26 detection detection NN cord-023095-4dannjjm 2321 27 . . . cord-023095-4dannjjm 2322 1 Protein protein NN cord-023095-4dannjjm 2322 2 binding binding NN cord-023095-4dannjjm 2322 3 was be VBD cord-023095-4dannjjm 2322 4 determined determine VBN cord-023095-4dannjjm 2322 5 with with IN cord-023095-4dannjjm 2322 6 a a DT cord-023095-4dannjjm 2322 7 microcentrifugation microcentrifugation NN cord-023095-4dannjjm 2322 8 system system NN cord-023095-4dannjjm 2322 9 . . . cord-023095-4dannjjm 2323 1 Pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 2323 2 data datum NNS cord-023095-4dannjjm 2323 3 was be VBD cord-023095-4dannjjm 2323 4 analyzed analyze VBN cord-023095-4dannjjm 2323 5 using use VBG cord-023095-4dannjjm 2323 6 a a DT cord-023095-4dannjjm 2323 7 one one CD cord-023095-4dannjjm 2323 8 compartment compartment NN cord-023095-4dannjjm 2323 9 model model NN cord-023095-4dannjjm 2323 10 . . . cord-023095-4dannjjm 2324 1 The the DT cord-023095-4dannjjm 2324 2 analysis analysis NN cord-023095-4dannjjm 2324 3 of of IN cord-023095-4dannjjm 2324 4 plasma plasma NN cord-023095-4dannjjm 2324 5 and and CC cord-023095-4dannjjm 2324 6 ISF ISF NNP cord-023095-4dannjjm 2324 7 showed show VBD cord-023095-4dannjjm 2324 8 that that IN cord-023095-4dannjjm 2324 9 only only RB cord-023095-4dannjjm 2324 10 a a DT cord-023095-4dannjjm 2324 11 small small JJ cord-023095-4dannjjm 2324 12 fraction fraction NN cord-023095-4dannjjm 2324 13 of of IN cord-023095-4dannjjm 2324 14 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 2324 15 was be VBD cord-023095-4dannjjm 2324 16 produced produce VBN cord-023095-4dannjjm 2324 17 in in IN cord-023095-4dannjjm 2324 18 these these DT cord-023095-4dannjjm 2324 19 pigs pig NNS cord-023095-4dannjjm 2324 20 , , , cord-023095-4dannjjm 2324 21 therefore therefore RB cord-023095-4dannjjm 2324 22 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 2324 23 concentrations concentration NNS cord-023095-4dannjjm 2324 24 were be VBD cord-023095-4dannjjm 2324 25 not not RB cord-023095-4dannjjm 2324 26 used use VBN cord-023095-4dannjjm 2324 27 in in IN cord-023095-4dannjjm 2324 28 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 2324 29 measurements measurement NNS cord-023095-4dannjjm 2324 30 . . . cord-023095-4dannjjm 2325 1 The the DT cord-023095-4dannjjm 2325 2 plasma plasma NN cord-023095-4dannjjm 2325 3 half half JJ cord-023095-4dannjjm 2325 4 - - HYPH cord-023095-4dannjjm 2325 5 life life NN cord-023095-4dannjjm 2325 6 ( ( -LRB- cord-023095-4dannjjm 2325 7 t t NN cord-023095-4dannjjm 2325 8 1/2 1/2 CD cord-023095-4dannjjm 2325 9 ) ) -RRB- cord-023095-4dannjjm 2325 10 , , , cord-023095-4dannjjm 2325 11 volume volume NN cord-023095-4dannjjm 2325 12 of of IN cord-023095-4dannjjm 2325 13 distribution distribution NN cord-023095-4dannjjm 2325 14 , , , cord-023095-4dannjjm 2325 15 clearance clearance NN cord-023095-4dannjjm 2325 16 , , , cord-023095-4dannjjm 2325 17 and and CC cord-023095-4dannjjm 2325 18 peak peak NN cord-023095-4dannjjm 2325 19 concentration concentration NN cord-023095-4dannjjm 2325 20 ( ( -LRB- cord-023095-4dannjjm 2325 21 C C NNP cord-023095-4dannjjm 2325 22 max max NNP cord-023095-4dannjjm 2325 23 ) ) -RRB- cord-023095-4dannjjm 2325 24 for for IN cord-023095-4dannjjm 2325 25 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 2325 26 was be VBD cord-023095-4dannjjm 2325 27 25.9 25.9 CD cord-023095-4dannjjm 2325 28 hr hr NN cord-023095-4dannjjm 2325 29 ( ( -LRB- cord-023095-4dannjjm 2325 30 AE AE NNP cord-023095-4dannjjm 2325 31 6.2 6.2 CD cord-023095-4dannjjm 2325 32 ) ) -RRB- cord-023095-4dannjjm 2325 33 , , , cord-023095-4dannjjm 2325 34 6.29 6.29 CD cord-023095-4dannjjm 2325 35 L l NN cord-023095-4dannjjm 2325 36 / / SYM cord-023095-4dannjjm 2325 37 kg kg NNP cord-023095-4dannjjm 2325 38 ( ( -LRB- cord-023095-4dannjjm 2325 39 AE AE NNP cord-023095-4dannjjm 2325 40 1.23 1.23 CD cord-023095-4dannjjm 2325 41 ) ) -RRB- cord-023095-4dannjjm 2325 42 , , , cord-023095-4dannjjm 2325 43 0.168 0.168 CD cord-023095-4dannjjm 2325 44 L l NN cord-023095-4dannjjm 2325 45 / / SYM cord-023095-4dannjjm 2325 46 kg kg NNP cord-023095-4dannjjm 2325 47 / / SYM cord-023095-4dannjjm 2325 48 hr hr NN cord-023095-4dannjjm 2325 49 ( ( -LRB- cord-023095-4dannjjm 2325 50 AE AE NNP cord-023095-4dannjjm 2325 51 0.076 0.076 CD cord-023095-4dannjjm 2325 52 ) ) -RRB- cord-023095-4dannjjm 2325 53 , , , cord-023095-4dannjjm 2325 54 and and CC cord-023095-4dannjjm 2325 55 1.07 1.07 CD cord-023095-4dannjjm 2325 56 mg mg NNP cord-023095-4dannjjm 2325 57 / / SYM cord-023095-4dannjjm 2325 58 mL mL NNP cord-023095-4dannjjm 2325 59 ( ( -LRB- cord-023095-4dannjjm 2325 60 AE AE NNP cord-023095-4dannjjm 2325 61 0.28 0.28 CD cord-023095-4dannjjm 2325 62 ) ) -RRB- cord-023095-4dannjjm 2325 63 , , , cord-023095-4dannjjm 2325 64 respectively respectively RB cord-023095-4dannjjm 2325 65 . . . cord-023095-4dannjjm 2326 1 The the DT cord-023095-4dannjjm 2326 2 concentrations concentration NNS cord-023095-4dannjjm 2326 3 from from IN cord-023095-4dannjjm 2326 4 each each DT cord-023095-4dannjjm 2326 5 of of IN cord-023095-4dannjjm 2326 6 three three CD cord-023095-4dannjjm 2326 7 tissues tissue NNS cord-023095-4dannjjm 2326 8 were be VBD cord-023095-4dannjjm 2326 9 not not RB cord-023095-4dannjjm 2326 10 different different JJ cord-023095-4dannjjm 2326 11 in in IN cord-023095-4dannjjm 2326 12 each each DT cord-023095-4dannjjm 2326 13 pig pig NN cord-023095-4dannjjm 2326 14 . . . cord-023095-4dannjjm 2327 1 When when WRB cord-023095-4dannjjm 2327 2 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 2327 3 values value NNS cord-023095-4dannjjm 2327 4 from from IN cord-023095-4dannjjm 2327 5 all all DT cord-023095-4dannjjm 2327 6 tissues tissue NNS cord-023095-4dannjjm 2327 7 were be VBD cord-023095-4dannjjm 2327 8 combined combine VBN cord-023095-4dannjjm 2327 9 for for IN cord-023095-4dannjjm 2327 10 the the DT cord-023095-4dannjjm 2327 11 ISF ISF NNP cord-023095-4dannjjm 2327 12 , , , cord-023095-4dannjjm 2327 13 the the DT cord-023095-4dannjjm 2327 14 t t NN cord-023095-4dannjjm 2327 15 1/2 1/2 CD cord-023095-4dannjjm 2327 16 was be VBD cord-023095-4dannjjm 2327 17 23.6 23.6 CD cord-023095-4dannjjm 2327 18 hr hr NN cord-023095-4dannjjm 2327 19 ( ( -LRB- cord-023095-4dannjjm 2327 20 AE AE NNP cord-023095-4dannjjm 2327 21 4.1 4.1 CD cord-023095-4dannjjm 2327 22 ) ) -RRB- cord-023095-4dannjjm 2327 23 and and CC cord-023095-4dannjjm 2327 24 the the DT cord-023095-4dannjjm 2327 25 C C NNP cord-023095-4dannjjm 2327 26 max max NN cord-023095-4dannjjm 2327 27 was be VBD cord-023095-4dannjjm 2327 28 1.26 1.26 CD cord-023095-4dannjjm 2327 29 mg mg NN cord-023095-4dannjjm 2327 30 / / SYM cord-023095-4dannjjm 2327 31 mL mL NNP cord-023095-4dannjjm 2327 32 ( ( -LRB- cord-023095-4dannjjm 2327 33 AE AE NNP cord-023095-4dannjjm 2327 34 0.10 0.10 CD cord-023095-4dannjjm 2327 35 ) ) -RRB- cord-023095-4dannjjm 2327 36 . . . cord-023095-4dannjjm 2328 1 The the DT cord-023095-4dannjjm 2328 2 enrofloxacin enrofloxacin JJ cord-023095-4dannjjm 2328 3 plasma plasma NN cord-023095-4dannjjm 2328 4 protein protein NN cord-023095-4dannjjm 2328 5 binding binding NN cord-023095-4dannjjm 2328 6 was be VBD cord-023095-4dannjjm 2328 7 31.1 31.1 CD cord-023095-4dannjjm 2328 8 % % NN cord-023095-4dannjjm 2328 9 ( ( -LRB- cord-023095-4dannjjm 2328 10 AE AE NNP cord-023095-4dannjjm 2328 11 3.28 3.28 CD cord-023095-4dannjjm 2328 12 ) ) -RRB- cord-023095-4dannjjm 2328 13 and and CC cord-023095-4dannjjm 2328 14 37.13 37.13 CD cord-023095-4dannjjm 2328 15 % % NN cord-023095-4dannjjm 2328 16 ( ( -LRB- cord-023095-4dannjjm 2328 17 AE AE NNP cord-023095-4dannjjm 2328 18 16.54 16.54 CD cord-023095-4dannjjm 2328 19 ) ) -RRB- cord-023095-4dannjjm 2328 20 at at IN cord-023095-4dannjjm 2328 21 a a DT cord-023095-4dannjjm 2328 22 high high JJ cord-023095-4dannjjm 2328 23 and and CC cord-023095-4dannjjm 2328 24 low low JJ cord-023095-4dannjjm 2328 25 concentration concentration NN cord-023095-4dannjjm 2328 26 , , , cord-023095-4dannjjm 2328 27 respectively respectively RB cord-023095-4dannjjm 2328 28 . . . cord-023095-4dannjjm 2329 1 This this DT cord-023095-4dannjjm 2329 2 study study NN cord-023095-4dannjjm 2329 3 has have VBZ cord-023095-4dannjjm 2329 4 demonstrated demonstrate VBN cord-023095-4dannjjm 2329 5 that that IN cord-023095-4dannjjm 2329 6 the the DT cord-023095-4dannjjm 2329 7 concentration concentration NN cord-023095-4dannjjm 2329 8 of of IN cord-023095-4dannjjm 2329 9 biologically biologically RB cord-023095-4dannjjm 2329 10 active active JJ cord-023095-4dannjjm 2329 11 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 2329 12 in in IN cord-023095-4dannjjm 2329 13 tissues tissue NNS cord-023095-4dannjjm 2329 14 exceeds exceed VBZ cord-023095-4dannjjm 2329 15 the the DT cord-023095-4dannjjm 2329 16 concentration concentration NN cord-023095-4dannjjm 2329 17 predicted predict VBN cord-023095-4dannjjm 2329 18 by by IN cord-023095-4dannjjm 2329 19 the the DT cord-023095-4dannjjm 2329 20 unbound unbound JJ cord-023095-4dannjjm 2329 21 fraction fraction NN cord-023095-4dannjjm 2329 22 of of IN cord-023095-4dannjjm 2329 23 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 2329 24 in in IN cord-023095-4dannjjm 2329 25 pig pig NN cord-023095-4dannjjm 2329 26 plasma plasma NN cord-023095-4dannjjm 2329 27 . . . cord-023095-4dannjjm 2330 1 The the DT cord-023095-4dannjjm 2330 2 half half JJ cord-023095-4dannjjm 2330 3 - - HYPH cord-023095-4dannjjm 2330 4 life life NN cord-023095-4dannjjm 2330 5 of of IN cord-023095-4dannjjm 2330 6 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 2330 7 is be VBZ cord-023095-4dannjjm 2330 8 longer long JJR cord-023095-4dannjjm 2330 9 in in IN cord-023095-4dannjjm 2330 10 tissues tissue NNS cord-023095-4dannjjm 2330 11 and and CC cord-023095-4dannjjm 2330 12 plasma plasma NN cord-023095-4dannjjm 2330 13 than than IN cord-023095-4dannjjm 2330 14 has have VBZ cord-023095-4dannjjm 2330 15 been be VBN cord-023095-4dannjjm 2330 16 reported report VBN cord-023095-4dannjjm 2330 17 in in IN cord-023095-4dannjjm 2330 18 previous previous JJ cord-023095-4dannjjm 2330 19 studies study NNS cord-023095-4dannjjm 2330 20 . . . cord-023095-4dannjjm 2331 1 The the DT cord-023095-4dannjjm 2331 2 high high JJ cord-023095-4dannjjm 2331 3 tissue tissue NN cord-023095-4dannjjm 2331 4 concentrations concentration NNS cord-023095-4dannjjm 2331 5 and and CC cord-023095-4dannjjm 2331 6 long long JJ cord-023095-4dannjjm 2331 7 half half JJ cord-023095-4dannjjm 2331 8 - - HYPH cord-023095-4dannjjm 2331 9 life life NN cord-023095-4dannjjm 2331 10 produce produce VBP cord-023095-4dannjjm 2331 11 an an DT cord-023095-4dannjjm 2331 12 AUC AUC NNP cord-023095-4dannjjm 2331 13 / / SYM cord-023095-4dannjjm 2331 14 MIC mic NN cord-023095-4dannjjm 2331 15 ratio ratio NN cord-023095-4dannjjm 2331 16 sufficient sufficient JJ cord-023095-4dannjjm 2331 17 for for IN cord-023095-4dannjjm 2331 18 the the DT cord-023095-4dannjjm 2331 19 pathogens pathogen NNS cord-023095-4dannjjm 2331 20 that that WDT cord-023095-4dannjjm 2331 21 cause cause VBP cord-023095-4dannjjm 2331 22 respiratory respiratory JJ cord-023095-4dannjjm 2331 23 infections infection NNS cord-023095-4dannjjm 2331 24 in in IN cord-023095-4dannjjm 2331 25 pigs pig NNS cord-023095-4dannjjm 2331 26 . . . cord-023095-4dannjjm 2332 1 Ceftiofur ceftiofur JJ cord-023095-4dannjjm 2332 2 crystalline crystalline NN cord-023095-4dannjjm 2332 3 free free JJ cord-023095-4dannjjm 2332 4 acid acid NN cord-023095-4dannjjm 2332 5 ( ( -LRB- cord-023095-4dannjjm 2332 6 CCFA CCFA NNP cord-023095-4dannjjm 2332 7 ) ) -RRB- cord-023095-4dannjjm 2332 8 , , , cord-023095-4dannjjm 2332 9 a a DT cord-023095-4dannjjm 2332 10 long long RB cord-023095-4dannjjm 2332 11 - - HYPH cord-023095-4dannjjm 2332 12 acting act VBG cord-023095-4dannjjm 2332 13 ceftiofur ceftiofur JJ cord-023095-4dannjjm 2332 14 formulation formulation NN cord-023095-4dannjjm 2332 15 labeled label VBN cord-023095-4dannjjm 2332 16 for for IN cord-023095-4dannjjm 2332 17 use use NN cord-023095-4dannjjm 2332 18 in in IN cord-023095-4dannjjm 2332 19 cattle cattle NNS cord-023095-4dannjjm 2332 20 , , , cord-023095-4dannjjm 2332 21 pigs pig NNS cord-023095-4dannjjm 2332 22 , , , cord-023095-4dannjjm 2332 23 and and CC cord-023095-4dannjjm 2332 24 horses horse NNS cord-023095-4dannjjm 2332 25 for for IN cord-023095-4dannjjm 2332 26 treatment treatment NN cord-023095-4dannjjm 2332 27 of of IN cord-023095-4dannjjm 2332 28 respiratory respiratory JJ cord-023095-4dannjjm 2332 29 disease disease NN cord-023095-4dannjjm 2332 30 has have VBZ cord-023095-4dannjjm 2332 31 been be VBN cord-023095-4dannjjm 2332 32 used use VBN cord-023095-4dannjjm 2332 33 for for IN cord-023095-4dannjjm 2332 34 treatment treatment NN cord-023095-4dannjjm 2332 35 of of IN cord-023095-4dannjjm 2332 36 ovine ovine JJ cord-023095-4dannjjm 2332 37 respiratory respiratory JJ cord-023095-4dannjjm 2332 38 infections infection NNS cord-023095-4dannjjm 2332 39 in in IN cord-023095-4dannjjm 2332 40 clinical clinical JJ cord-023095-4dannjjm 2332 41 practice practice NN cord-023095-4dannjjm 2332 42 . . . cord-023095-4dannjjm 2333 1 Pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 2333 2 data datum NNS cord-023095-4dannjjm 2333 3 , , , cord-023095-4dannjjm 2333 4 however however RB cord-023095-4dannjjm 2333 5 , , , cord-023095-4dannjjm 2333 6 do do VBP cord-023095-4dannjjm 2333 7 not not RB cord-023095-4dannjjm 2333 8 exist exist VB cord-023095-4dannjjm 2333 9 for for IN cord-023095-4dannjjm 2333 10 CCFA CCFA NNP cord-023095-4dannjjm 2333 11 administered administer VBN cord-023095-4dannjjm 2333 12 subcutaneously subcutaneously RB cord-023095-4dannjjm 2333 13 in in IN cord-023095-4dannjjm 2333 14 sheep sheep NNS cord-023095-4dannjjm 2333 15 . . . cord-023095-4dannjjm 2334 1 The the DT cord-023095-4dannjjm 2334 2 present present JJ cord-023095-4dannjjm 2334 3 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 2334 4 study study NN cord-023095-4dannjjm 2334 5 evaluated evaluate VBD cord-023095-4dannjjm 2334 6 the the DT cord-023095-4dannjjm 2334 7 single single JJ cord-023095-4dannjjm 2334 8 dose dose NN cord-023095-4dannjjm 2334 9 subcutaneous subcutaneous JJ cord-023095-4dannjjm 2334 10 administration administration NN cord-023095-4dannjjm 2334 11 of of IN cord-023095-4dannjjm 2334 12 CCFA CCFA NNP cord-023095-4dannjjm 2334 13 in in IN cord-023095-4dannjjm 2334 14 sheep sheep NN cord-023095-4dannjjm 2334 15 ( ( -LRB- cord-023095-4dannjjm 2334 16 n n NN cord-023095-4dannjjm 2334 17 5 5 CD cord-023095-4dannjjm 2334 18 9 9 CD cord-023095-4dannjjm 2334 19 ) ) -RRB- cord-023095-4dannjjm 2334 20 at at IN cord-023095-4dannjjm 2334 21 6.6 6.6 CD cord-023095-4dannjjm 2334 22 mg mg NNP cord-023095-4dannjjm 2334 23 / / SYM cord-023095-4dannjjm 2334 24 kg kg NN cord-023095-4dannjjm 2334 25 body body NN cord-023095-4dannjjm 2334 26 weight weight NN cord-023095-4dannjjm 2334 27 . . . cord-023095-4dannjjm 2335 1 Concentrations concentration NNS cord-023095-4dannjjm 2335 2 of of IN cord-023095-4dannjjm 2335 3 ceftiofur ceftiofur JJ cord-023095-4dannjjm 2335 4 free free JJ cord-023095-4dannjjm 2335 5 acid acid NN cord-023095-4dannjjm 2335 6 equivalents equivalent NNS cord-023095-4dannjjm 2335 7 ( ( -LRB- cord-023095-4dannjjm 2335 8 CFAE CFAE NNP cord-023095-4dannjjm 2335 9 ) ) -RRB- cord-023095-4dannjjm 2335 10 in in IN cord-023095-4dannjjm 2335 11 plasma plasma NN cord-023095-4dannjjm 2335 12 were be VBD cord-023095-4dannjjm 2335 13 measured measure VBN cord-023095-4dannjjm 2335 14 by by IN cord-023095-4dannjjm 2335 15 high high JJ cord-023095-4dannjjm 2335 16 performance performance NN cord-023095-4dannjjm 2335 17 liquid liquid NN cord-023095-4dannjjm 2335 18 chromatography chromatography NN cord-023095-4dannjjm 2335 19 for for IN cord-023095-4dannjjm 2335 20 14 14 CD cord-023095-4dannjjm 2335 21 days day NNS cord-023095-4dannjjm 2335 22 following follow VBG cord-023095-4dannjjm 2335 23 drug drug NN cord-023095-4dannjjm 2335 24 administration administration NN cord-023095-4dannjjm 2335 25 . . . cord-023095-4dannjjm 2336 1 Pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 2336 2 of of IN cord-023095-4dannjjm 2336 3 subcutaneous subcutaneous JJ cord-023095-4dannjjm 2336 4 CCFA CCFA NNP cord-023095-4dannjjm 2336 5 in in IN cord-023095-4dannjjm 2336 6 sheep sheep NNS cord-023095-4dannjjm 2336 7 were be VBD cord-023095-4dannjjm 2336 8 best best RB cord-023095-4dannjjm 2336 9 described describe VBN cord-023095-4dannjjm 2336 10 using use VBG cord-023095-4dannjjm 2336 11 a a DT cord-023095-4dannjjm 2336 12 single single JJ cord-023095-4dannjjm 2336 13 compartment compartment NN cord-023095-4dannjjm 2336 14 model model NN cord-023095-4dannjjm 2336 15 with with IN cord-023095-4dannjjm 2336 16 the the DT cord-023095-4dannjjm 2336 17 following following JJ cord-023095-4dannjjm 2336 18 average average NN cord-023095-4dannjjm 2336 19 ( ( -LRB- cord-023095-4dannjjm 2336 20 AE AE NNP cord-023095-4dannjjm 2336 21 SD SD NNP cord-023095-4dannjjm 2336 22 ) ) -RRB- cord-023095-4dannjjm 2336 23 parameters parameter NNS cord-023095-4dannjjm 2336 24 : : : cord-023095-4dannjjm 2336 25 area area NN cord-023095-4dannjjm 2336 26 under under IN cord-023095-4dannjjm 2336 27 the the DT cord-023095-4dannjjm 2336 28 concentration concentration NN cord-023095-4dannjjm 2336 29 time time NN cord-023095-4dannjjm 2336 30 curve curve NN cord-023095-4dannjjm 2336 31 0 0 NFP cord-023095-4dannjjm 2336 32 ! ! . cord-023095-4dannjjm 2337 1 1 1 LS cord-023095-4dannjjm 2338 1 ( ( -LRB- cord-023095-4dannjjm 2338 2 206.6 206.6 CD cord-023095-4dannjjm 2338 3 hÃug hÃug NNP cord-023095-4dannjjm 2338 4 / / SYM cord-023095-4dannjjm 2338 5 ml ml NN cord-023095-4dannjjm 2338 6 AE AE NNP cord-023095-4dannjjm 2338 7 24.8 24.8 CD cord-023095-4dannjjm 2338 8 ) ) -RRB- cord-023095-4dannjjm 2338 9 , , , cord-023095-4dannjjm 2338 10 observed observe VBD cord-023095-4dannjjm 2338 11 maximum maximum JJ cord-023095-4dannjjm 2338 12 plasma plasma NN cord-023095-4dannjjm 2338 13 concentration concentration NN cord-023095-4dannjjm 2338 14 ( ( -LRB- cord-023095-4dannjjm 2338 15 2.4 2.4 CD cord-023095-4dannjjm 2338 16 ug/ ug/ JJ cord-023095-4dannjjm 2338 17 ml ml NN cord-023095-4dannjjm 2338 18 AE AE NNP cord-023095-4dannjjm 2338 19 0.5 0.5 CD cord-023095-4dannjjm 2338 20 ) ) -RRB- cord-023095-4dannjjm 2338 21 , , , cord-023095-4dannjjm 2338 22 and and CC cord-023095-4dannjjm 2338 23 observed observe VBD cord-023095-4dannjjm 2338 24 time time NN cord-023095-4dannjjm 2338 25 of of IN cord-023095-4dannjjm 2338 26 maximum maximum JJ cord-023095-4dannjjm 2338 27 plasma plasma NN cord-023095-4dannjjm 2338 28 concentration concentration NN cord-023095-4dannjjm 2338 29 ( ( -LRB- cord-023095-4dannjjm 2338 30 23.1 23.1 CD cord-023095-4dannjjm 2338 31 h h NN cord-023095-4dannjjm 2338 32 AE AE NNP cord-023095-4dannjjm 2338 33 10.1 10.1 CD cord-023095-4dannjjm 2338 34 ) ) -RRB- cord-023095-4dannjjm 2338 35 . . . cord-023095-4dannjjm 2339 1 No no DT cord-023095-4dannjjm 2339 2 significant significant JJ cord-023095-4dannjjm 2339 3 adverse adverse JJ cord-023095-4dannjjm 2339 4 drug drug NN cord-023095-4dannjjm 2339 5 reactions reaction NNS cord-023095-4dannjjm 2339 6 were be VBD cord-023095-4dannjjm 2339 7 observed observe VBN cord-023095-4dannjjm 2339 8 . . . cord-023095-4dannjjm 2340 1 Adequate adequate JJ cord-023095-4dannjjm 2340 2 CFAE CFAE NNP cord-023095-4dannjjm 2340 3 plasma plasma NN cord-023095-4dannjjm 2340 4 concentrations concentration NNS cord-023095-4dannjjm 2340 5 were be VBD cord-023095-4dannjjm 2340 6 attained attain VBN cord-023095-4dannjjm 2340 7 to to TO cord-023095-4dannjjm 2340 8 effectively effectively RB cord-023095-4dannjjm 2340 9 treat treat VB cord-023095-4dannjjm 2340 10 respiratory respiratory JJ cord-023095-4dannjjm 2340 11 tract tract NN cord-023095-4dannjjm 2340 12 pathogens pathogen NNS cord-023095-4dannjjm 2340 13 associated associate VBN cord-023095-4dannjjm 2340 14 with with IN cord-023095-4dannjjm 2340 15 pneumonia pneumonia NN cord-023095-4dannjjm 2340 16 in in IN cord-023095-4dannjjm 2340 17 sheep sheep NN cord-023095-4dannjjm 2340 18 . . . cord-023095-4dannjjm 2341 1 The the DT cord-023095-4dannjjm 2341 2 purpose purpose NN cord-023095-4dannjjm 2341 3 of of IN cord-023095-4dannjjm 2341 4 this this DT cord-023095-4dannjjm 2341 5 study study NN cord-023095-4dannjjm 2341 6 was be VBD cord-023095-4dannjjm 2341 7 to to TO cord-023095-4dannjjm 2341 8 assess assess VB cord-023095-4dannjjm 2341 9 , , , cord-023095-4dannjjm 2341 10 using use VBG cord-023095-4dannjjm 2341 11 thoracic thoracic JJ cord-023095-4dannjjm 2341 12 ultrasonography ultrasonography NN cord-023095-4dannjjm 2341 13 , , , cord-023095-4dannjjm 2341 14 the the DT cord-023095-4dannjjm 2341 15 prevalence prevalence NN cord-023095-4dannjjm 2341 16 of of IN cord-023095-4dannjjm 2341 17 lung lung NN cord-023095-4dannjjm 2341 18 lesions lesion NNS cord-023095-4dannjjm 2341 19 in in IN cord-023095-4dannjjm 2341 20 pre pre JJ cord-023095-4dannjjm 2341 21 - - JJ cord-023095-4dannjjm 2341 22 weaned wean VBN cord-023095-4dannjjm 2341 23 dairy dairy NN cord-023095-4dannjjm 2341 24 calves calf NNS cord-023095-4dannjjm 2341 25 . . . cord-023095-4dannjjm 2342 1 Subsequent subsequent JJ cord-023095-4dannjjm 2342 2 aims aim NNS cord-023095-4dannjjm 2342 3 were be VBD cord-023095-4dannjjm 2342 4 to to TO cord-023095-4dannjjm 2342 5 describe describe VB cord-023095-4dannjjm 2342 6 ultrasonographic ultrasonographic JJ cord-023095-4dannjjm 2342 7 changes change NNS cord-023095-4dannjjm 2342 8 within within IN cord-023095-4dannjjm 2342 9 the the DT cord-023095-4dannjjm 2342 10 lung lung NN cord-023095-4dannjjm 2342 11 , , , cord-023095-4dannjjm 2342 12 clinical clinical JJ cord-023095-4dannjjm 2342 13 respiratory respiratory JJ cord-023095-4dannjjm 2342 14 score score NN cord-023095-4dannjjm 2342 15 , , , cord-023095-4dannjjm 2342 16 and and CC cord-023095-4dannjjm 2342 17 treatment treatment NN cord-023095-4dannjjm 2342 18 of of IN cord-023095-4dannjjm 2342 19 respiratory respiratory JJ cord-023095-4dannjjm 2342 20 disease disease NN cord-023095-4dannjjm 2342 21 . . . cord-023095-4dannjjm 2343 1 A a DT cord-023095-4dannjjm 2343 2 longitudinal longitudinal JJ cord-023095-4dannjjm 2343 3 study study NN cord-023095-4dannjjm 2343 4 was be VBD cord-023095-4dannjjm 2343 5 performed perform VBN cord-023095-4dannjjm 2343 6 using use VBG cord-023095-4dannjjm 2343 7 female female JJ cord-023095-4dannjjm 2343 8 dairy dairy NN cord-023095-4dannjjm 2343 9 calves calf NNS cord-023095-4dannjjm 2343 10 from from IN cord-023095-4dannjjm 2343 11 6 6 CD cord-023095-4dannjjm 2343 12 commercial commercial JJ cord-023095-4dannjjm 2343 13 dairy dairy NN cord-023095-4dannjjm 2343 14 farms farm NNS cord-023095-4dannjjm 2343 15 in in IN cord-023095-4dannjjm 2343 16 New New NNP cord-023095-4dannjjm 2343 17 York York NNP cord-023095-4dannjjm 2343 18 State State NNP cord-023095-4dannjjm 2343 19 . . . cord-023095-4dannjjm 2344 1 Calves calf NNS cord-023095-4dannjjm 2344 2 were be VBD cord-023095-4dannjjm 2344 3 enrolled enrol VBN cord-023095-4dannjjm 2344 4 based base VBN cord-023095-4dannjjm 2344 5 on on IN cord-023095-4dannjjm 2344 6 age age NN cord-023095-4dannjjm 2344 7 . . . cord-023095-4dannjjm 2345 1 Thoracic thoracic JJ cord-023095-4dannjjm 2345 2 ultrasound ultrasound NN cord-023095-4dannjjm 2345 3 and and CC cord-023095-4dannjjm 2345 4 clinical clinical JJ cord-023095-4dannjjm 2345 5 respiratory respiratory JJ cord-023095-4dannjjm 2345 6 scoring scoring NN cord-023095-4dannjjm 2345 7 were be VBD cord-023095-4dannjjm 2345 8 performed perform VBN cord-023095-4dannjjm 2345 9 on on IN cord-023095-4dannjjm 2345 10 each each DT cord-023095-4dannjjm 2345 11 calf calf NN cord-023095-4dannjjm 2345 12 at at IN cord-023095-4dannjjm 2345 13 2 2 CD cord-023095-4dannjjm 2345 14 time time NN cord-023095-4dannjjm 2345 15 points point NNS cord-023095-4dannjjm 2345 16 . . . cord-023095-4dannjjm 2346 1 A a DT cord-023095-4dannjjm 2346 2 standard standard JJ cord-023095-4dannjjm 2346 3 5 5 CD cord-023095-4dannjjm 2346 4 mHz mHz NNPS cord-023095-4dannjjm 2346 5 linear linear JJ cord-023095-4dannjjm 2346 6 ultrasound ultrasound NN cord-023095-4dannjjm 2346 7 probe probe NN cord-023095-4dannjjm 2346 8 was be VBD cord-023095-4dannjjm 2346 9 utilized utilize VBN cord-023095-4dannjjm 2346 10 to to TO cord-023095-4dannjjm 2346 11 evaluate evaluate VB cord-023095-4dannjjm 2346 12 intercostal intercostal JJ cord-023095-4dannjjm 2346 13 spaces space NNS cord-023095-4dannjjm 2346 14 1 1 CD cord-023095-4dannjjm 2346 15 through through IN cord-023095-4dannjjm 2346 16 11 11 CD cord-023095-4dannjjm 2346 17 of of IN cord-023095-4dannjjm 2346 18 each each DT cord-023095-4dannjjm 2346 19 hemi hemi NN cord-023095-4dannjjm 2346 20 - - HYPH cord-023095-4dannjjm 2346 21 thorax thorax NN cord-023095-4dannjjm 2346 22 with with IN cord-023095-4dannjjm 2346 23 the the DT cord-023095-4dannjjm 2346 24 calf calf NN cord-023095-4dannjjm 2346 25 in in IN cord-023095-4dannjjm 2346 26 lateral lateral JJ cord-023095-4dannjjm 2346 27 recumbency recumbency NN cord-023095-4dannjjm 2346 28 ( ( -LRB- cord-023095-4dannjjm 2346 29 US1 US1 NNP cord-023095-4dannjjm 2346 30 ) ) -RRB- cord-023095-4dannjjm 2346 31 or or CC cord-023095-4dannjjm 2346 32 standing stand VBG cord-023095-4dannjjm 2346 33 ( ( -LRB- cord-023095-4dannjjm 2346 34 US2 US2 NNP cord-023095-4dannjjm 2346 35 ) ) -RRB- cord-023095-4dannjjm 2346 36 . . . cord-023095-4dannjjm 2347 1 Lesion lesion NN cord-023095-4dannjjm 2347 2 appearance appearance NN cord-023095-4dannjjm 2347 3 , , , cord-023095-4dannjjm 2347 4 size size NN cord-023095-4dannjjm 2347 5 , , , cord-023095-4dannjjm 2347 6 and and CC cord-023095-4dannjjm 2347 7 location location NN cord-023095-4dannjjm 2347 8 were be VBD cord-023095-4dannjjm 2347 9 recorded record VBN cord-023095-4dannjjm 2347 10 . . . cord-023095-4dannjjm 2348 1 Respiratory respiratory JJ cord-023095-4dannjjm 2348 2 score score NN cord-023095-4dannjjm 2348 3 ( ( -LRB- cord-023095-4dannjjm 2348 4 RS rs NN cord-023095-4dannjjm 2348 5 ) ) -RRB- cord-023095-4dannjjm 2348 6 was be VBD cord-023095-4dannjjm 2348 7 assigned assign VBN cord-023095-4dannjjm 2348 8 based base VBN cord-023095-4dannjjm 2348 9 on on IN cord-023095-4dannjjm 2348 10 a a DT cord-023095-4dannjjm 2348 11 previously previously RB cord-023095-4dannjjm 2348 12 published publish VBN cord-023095-4dannjjm 2348 13 protocol protocol NN cord-023095-4dannjjm 2348 14 incorporating incorporate VBG cord-023095-4dannjjm 2348 15 fever fever NN cord-023095-4dannjjm 2348 16 , , , cord-023095-4dannjjm 2348 17 nasal nasal NN cord-023095-4dannjjm 2348 18 discharge discharge NN cord-023095-4dannjjm 2348 19 , , , cord-023095-4dannjjm 2348 20 cough cough NN cord-023095-4dannjjm 2348 21 , , , cord-023095-4dannjjm 2348 22 ocular ocular JJ cord-023095-4dannjjm 2348 23 discharge discharge NN cord-023095-4dannjjm 2348 24 and and CC cord-023095-4dannjjm 2348 25 ear ear NN cord-023095-4dannjjm 2348 26 droop droop VBP cord-023095-4dannjjm 2348 27 , , , cord-023095-4dannjjm 2348 28 with with IN cord-023095-4dannjjm 2348 29 a a DT cord-023095-4dannjjm 2348 30 higher high JJR cord-023095-4dannjjm 2348 31 numerical numerical JJ cord-023095-4dannjjm 2348 32 score score NN cord-023095-4dannjjm 2348 33 corresponding correspond VBG cord-023095-4dannjjm 2348 34 to to IN cord-023095-4dannjjm 2348 35 more more RBR cord-023095-4dannjjm 2348 36 severe severe JJ cord-023095-4dannjjm 2348 37 disease disease NN cord-023095-4dannjjm 2348 38 . . . cord-023095-4dannjjm 2349 1 Abnormal abnormal JJ cord-023095-4dannjjm 2349 2 lung lung NN cord-023095-4dannjjm 2349 3 on on IN cord-023095-4dannjjm 2349 4 ultrasound ultrasound NN cord-023095-4dannjjm 2349 5 was be VBD cord-023095-4dannjjm 2349 6 defined define VBN cord-023095-4dannjjm 2349 7 as as IN cord-023095-4dannjjm 2349 8 one one CD cord-023095-4dannjjm 2349 9 or or CC cord-023095-4dannjjm 2349 10 more more JJR cord-023095-4dannjjm 2349 11 areas area NNS cord-023095-4dannjjm 2349 12 of of IN cord-023095-4dannjjm 2349 13 ! ! . cord-023095-4dannjjm 2349 14 1 1 CD cord-023095-4dannjjm 2349 15 cm cm NN cord-023095-4dannjjm 2349 16 width width NN cord-023095-4dannjjm 2349 17 or or CC cord-023095-4dannjjm 2349 18 depth depth NN cord-023095-4dannjjm 2349 19 of of IN cord-023095-4dannjjm 2349 20 non non JJ cord-023095-4dannjjm 2349 21 - - JJ cord-023095-4dannjjm 2349 22 aerated aerated JJ cord-023095-4dannjjm 2349 23 lung lung NN cord-023095-4dannjjm 2349 24 . . . cord-023095-4dannjjm 2350 1 Farm farm NN cord-023095-4dannjjm 2350 2 records record NNS cord-023095-4dannjjm 2350 3 were be VBD cord-023095-4dannjjm 2350 4 evaluated evaluate VBN cord-023095-4dannjjm 2350 5 to to TO cord-023095-4dannjjm 2350 6 identify identify VB cord-023095-4dannjjm 2350 7 treated treat VBN cord-023095-4dannjjm 2350 8 calves calf NNS cord-023095-4dannjjm 2350 9 . . . cord-023095-4dannjjm 2351 1 Calves calf NNS cord-023095-4dannjjm 2351 2 were be VBD cord-023095-4dannjjm 2351 3 treated treat VBN cord-023095-4dannjjm 2351 4 for for IN cord-023095-4dannjjm 2351 5 respiratory respiratory JJ cord-023095-4dannjjm 2351 6 disease disease NN cord-023095-4dannjjm 2351 7 at at IN cord-023095-4dannjjm 2351 8 the the DT cord-023095-4dannjjm 2351 9 farm farm NN cord-023095-4dannjjm 2351 10 manager manager NN cord-023095-4dannjjm 2351 11 's 's POS cord-023095-4dannjjm 2351 12 discretion discretion NN cord-023095-4dannjjm 2351 13 , , , cord-023095-4dannjjm 2351 14 not not RB cord-023095-4dannjjm 2351 15 based base VBN cord-023095-4dannjjm 2351 16 upon upon IN cord-023095-4dannjjm 2351 17 ultrasound ultrasound NN cord-023095-4dannjjm 2351 18 findings finding NNS cord-023095-4dannjjm 2351 19 or or CC cord-023095-4dannjjm 2351 20 RS rs NN cord-023095-4dannjjm 2351 21 . . . cord-023095-4dannjjm 2352 1 Non non JJ cord-023095-4dannjjm 2352 2 - - JJ cord-023095-4dannjjm 2352 3 parametric parametric JJ cord-023095-4dannjjm 2352 4 methods method NNS cord-023095-4dannjjm 2352 5 were be VBD cord-023095-4dannjjm 2352 6 used use VBN cord-023095-4dannjjm 2352 7 to to TO cord-023095-4dannjjm 2352 8 evaluate evaluate VB cord-023095-4dannjjm 2352 9 the the DT cord-023095-4dannjjm 2352 10 data datum NNS cord-023095-4dannjjm 2352 11 . . . cord-023095-4dannjjm 2353 1 Ninety ninety CD cord-023095-4dannjjm 2353 2 - - HYPH cord-023095-4dannjjm 2353 3 one one CD cord-023095-4dannjjm 2353 4 calves calf NNS cord-023095-4dannjjm 2353 5 were be VBD cord-023095-4dannjjm 2353 6 enrolled enrol VBN cord-023095-4dannjjm 2353 7 into into IN cord-023095-4dannjjm 2353 8 the the DT cord-023095-4dannjjm 2353 9 study study NN cord-023095-4dannjjm 2353 10 , , , cord-023095-4dannjjm 2353 11 with with IN cord-023095-4dannjjm 2353 12 6 6 CD cord-023095-4dannjjm 2353 13 lost lose VBN cord-023095-4dannjjm 2353 14 to to TO cord-023095-4dannjjm 2353 15 follow follow VB cord-023095-4dannjjm 2353 16 - - HYPH cord-023095-4dannjjm 2353 17 up up NN cord-023095-4dannjjm 2353 18 . . . cord-023095-4dannjjm 2354 1 An an DT cord-023095-4dannjjm 2354 2 average average NN cord-023095-4dannjjm 2354 3 of of IN cord-023095-4dannjjm 2354 4 4 4 CD cord-023095-4dannjjm 2354 5 minutes minute NNS cord-023095-4dannjjm 2354 6 was be VBD cord-023095-4dannjjm 2354 7 spent spend VBN cord-023095-4dannjjm 2354 8 performing perform VBG cord-023095-4dannjjm 2354 9 the the DT cord-023095-4dannjjm 2354 10 RS rs NN cord-023095-4dannjjm 2354 11 and and CC cord-023095-4dannjjm 2354 12 ultrasound ultrasound NN cord-023095-4dannjjm 2354 13 on on IN cord-023095-4dannjjm 2354 14 each each DT cord-023095-4dannjjm 2354 15 calf calf NN cord-023095-4dannjjm 2354 16 . . . cord-023095-4dannjjm 2355 1 The the DT cord-023095-4dannjjm 2355 2 median median JJ cord-023095-4dannjjm 2355 3 ages age NNS cord-023095-4dannjjm 2355 4 at at IN cord-023095-4dannjjm 2355 5 first first JJ cord-023095-4dannjjm 2355 6 ( ( -LRB- cord-023095-4dannjjm 2355 7 US1 US1 NNP cord-023095-4dannjjm 2355 8 ) ) -RRB- cord-023095-4dannjjm 2355 9 and and CC cord-023095-4dannjjm 2356 1 second second LS cord-023095-4dannjjm 2356 2 ( ( -LRB- cord-023095-4dannjjm 2356 3 US2 US2 NNP cord-023095-4dannjjm 2356 4 ) ) -RRB- cord-023095-4dannjjm 2356 5 examination examination NN cord-023095-4dannjjm 2356 6 were be VBD cord-023095-4dannjjm 2356 7 13 13 CD cord-023095-4dannjjm 2357 1 ( ( -LRB- cord-023095-4dannjjm 2357 2 interquartile interquartile JJ cord-023095-4dannjjm 2357 3 range range VBP cord-023095-4dannjjm 2357 4 12 12 CD cord-023095-4dannjjm 2357 5 - - SYM cord-023095-4dannjjm 2357 6 15 15 CD cord-023095-4dannjjm 2357 7 ) ) -RRB- cord-023095-4dannjjm 2357 8 and and CC cord-023095-4dannjjm 2357 9 46 46 CD cord-023095-4dannjjm 2358 1 ( ( -LRB- cord-023095-4dannjjm 2358 2 interquartile interquartile JJ cord-023095-4dannjjm 2358 3 range range VBP cord-023095-4dannjjm 2358 4 44 44 CD cord-023095-4dannjjm 2358 5 - - SYM cord-023095-4dannjjm 2358 6 47 47 CD cord-023095-4dannjjm 2358 7 ) ) -RRB- cord-023095-4dannjjm 2358 8 days day NNS cord-023095-4dannjjm 2358 9 , , , cord-023095-4dannjjm 2358 10 respectively respectively RB cord-023095-4dannjjm 2358 11 . . . cord-023095-4dannjjm 2359 1 The the DT cord-023095-4dannjjm 2359 2 majority majority NN cord-023095-4dannjjm 2359 3 of of IN cord-023095-4dannjjm 2359 4 calves calf NNS cord-023095-4dannjjm 2359 5 had have VBD cord-023095-4dannjjm 2359 6 a a DT cord-023095-4dannjjm 2359 7 low low JJ cord-023095-4dannjjm 2359 8 RS rs NN cord-023095-4dannjjm 2359 9 ( ( -LRB- cord-023095-4dannjjm 2359 10 o o NN cord-023095-4dannjjm 2359 11 5 5 CD cord-023095-4dannjjm 2359 12 ) ) -RRB- cord-023095-4dannjjm 2359 13 and and CC cord-023095-4dannjjm 2359 14 only only RB cord-023095-4dannjjm 2359 15 3.2 3.2 CD cord-023095-4dannjjm 2359 16 % % NN cord-023095-4dannjjm 2359 17 of of IN cord-023095-4dannjjm 2359 18 calves calf NNS cord-023095-4dannjjm 2359 19 had have VBD cord-023095-4dannjjm 2359 20 a a DT cord-023095-4dannjjm 2359 21 RS rs NN cord-023095-4dannjjm 2359 22 high high JJ cord-023095-4dannjjm 2359 23 enough enough RB cord-023095-4dannjjm 2359 24 to to TO cord-023095-4dannjjm 2359 25 warrant warrant VB cord-023095-4dannjjm 2359 26 treatment treatment NN cord-023095-4dannjjm 2359 27 based base VBN cord-023095-4dannjjm 2359 28 on on IN cord-023095-4dannjjm 2359 29 previous previous JJ cord-023095-4dannjjm 2359 30 recommendations recommendation NNS cord-023095-4dannjjm 2359 31 ( ( -LRB- cord-023095-4dannjjm 2359 32 RS!5 RS!5 NNP cord-023095-4dannjjm 2359 33 ) ) -RRB- cord-023095-4dannjjm 2359 34 . . . cord-023095-4dannjjm 2360 1 The the DT cord-023095-4dannjjm 2360 2 prevalence prevalence NN cord-023095-4dannjjm 2360 3 of of IN cord-023095-4dannjjm 2360 4 calves calf NNS cord-023095-4dannjjm 2360 5 that that WDT cord-023095-4dannjjm 2360 6 had have VBD cord-023095-4dannjjm 2360 7 abnormal abnormal JJ cord-023095-4dannjjm 2360 8 lungs lung NNS cord-023095-4dannjjm 2360 9 on on IN cord-023095-4dannjjm 2360 10 ultrasound ultrasound NN cord-023095-4dannjjm 2360 11 but but CC cord-023095-4dannjjm 2360 12 a a DT cord-023095-4dannjjm 2360 13 low low JJ cord-023095-4dannjjm 2360 14 RS rs NN cord-023095-4dannjjm 2360 15 ( ( -LRB- cord-023095-4dannjjm 2360 16 o o NN cord-023095-4dannjjm 2360 17 5 5 CD cord-023095-4dannjjm 2360 18 ) ) -RRB- cord-023095-4dannjjm 2360 19 was be VBD cord-023095-4dannjjm 2360 20 5.5 5.5 CD cord-023095-4dannjjm 2360 21 % % NN cord-023095-4dannjjm 2360 22 ( ( -LRB- cord-023095-4dannjjm 2360 23 US1 US1 NNP cord-023095-4dannjjm 2360 24 ) ) -RRB- cord-023095-4dannjjm 2360 25 and and CC cord-023095-4dannjjm 2360 26 16.5 16.5 CD cord-023095-4dannjjm 2360 27 % % NN cord-023095-4dannjjm 2360 28 ( ( -LRB- cord-023095-4dannjjm 2360 29 US2 US2 NNP cord-023095-4dannjjm 2360 30 ) ) -RRB- cord-023095-4dannjjm 2360 31 . . . cord-023095-4dannjjm 2361 1 The the DT cord-023095-4dannjjm 2361 2 prevalence prevalence NN cord-023095-4dannjjm 2361 3 of of IN cord-023095-4dannjjm 2361 4 calves calf NNS cord-023095-4dannjjm 2361 5 that that WDT cord-023095-4dannjjm 2361 6 had have VBD cord-023095-4dannjjm 2361 7 abnormal abnormal JJ cord-023095-4dannjjm 2361 8 lungs lung NNS cord-023095-4dannjjm 2361 9 on on IN cord-023095-4dannjjm 2361 10 ultrasound ultrasound NN cord-023095-4dannjjm 2361 11 and and CC cord-023095-4dannjjm 2361 12 a a DT cord-023095-4dannjjm 2361 13 high high JJ cord-023095-4dannjjm 2361 14 RS rs NN cord-023095-4dannjjm 2361 15 ( ( -LRB- cord-023095-4dannjjm 2361 16 ! ! . cord-023095-4dannjjm 2361 17 5 5 LS cord-023095-4dannjjm 2361 18 ) ) -RRB- cord-023095-4dannjjm 2361 19 was be VBD cord-023095-4dannjjm 2361 20 0 0 CD cord-023095-4dannjjm 2361 21 % % NN cord-023095-4dannjjm 2361 22 ( ( -LRB- cord-023095-4dannjjm 2361 23 US1 US1 NNP cord-023095-4dannjjm 2361 24 ) ) -RRB- cord-023095-4dannjjm 2361 25 and and CC cord-023095-4dannjjm 2361 26 3.5 3.5 CD cord-023095-4dannjjm 2361 27 % % NN cord-023095-4dannjjm 2361 28 ( ( -LRB- cord-023095-4dannjjm 2361 29 US2 US2 NNP cord-023095-4dannjjm 2361 30 ) ) -RRB- cord-023095-4dannjjm 2361 31 . . . cord-023095-4dannjjm 2362 1 Of of IN cord-023095-4dannjjm 2362 2 the the DT cord-023095-4dannjjm 2362 3 calves calf NNS cord-023095-4dannjjm 2362 4 that that WDT cord-023095-4dannjjm 2362 5 had have VBD cord-023095-4dannjjm 2362 6 abnormal abnormal JJ cord-023095-4dannjjm 2362 7 lungs lung NNS cord-023095-4dannjjm 2362 8 on on IN cord-023095-4dannjjm 2362 9 ultrasound ultrasound NN cord-023095-4dannjjm 2362 10 but but CC cord-023095-4dannjjm 2362 11 a a DT cord-023095-4dannjjm 2362 12 low low JJ cord-023095-4dannjjm 2362 13 RS rs NN cord-023095-4dannjjm 2362 14 , , , cord-023095-4dannjjm 2362 15 13 13 CD cord-023095-4dannjjm 2362 16 % % NN cord-023095-4dannjjm 2362 17 were be VBD cord-023095-4dannjjm 2362 18 treated treat VBN cord-023095-4dannjjm 2362 19 with with IN cord-023095-4dannjjm 2362 20 antimicrobials antimicrobial NNS cord-023095-4dannjjm 2362 21 within within IN cord-023095-4dannjjm 2362 22 7 7 CD cord-023095-4dannjjm 2362 23 days day NNS cord-023095-4dannjjm 2362 24 of of IN cord-023095-4dannjjm 2362 25 examination examination NN cord-023095-4dannjjm 2362 26 . . . cord-023095-4dannjjm 2363 1 None none NN cord-023095-4dannjjm 2363 2 of of IN cord-023095-4dannjjm 2363 3 the the DT cord-023095-4dannjjm 2363 4 calves calf NNS cord-023095-4dannjjm 2363 5 with with IN cord-023095-4dannjjm 2363 6 high high JJ cord-023095-4dannjjm 2363 7 RS rs NN cord-023095-4dannjjm 2363 8 and and CC cord-023095-4dannjjm 2363 9 abnormal abnormal JJ cord-023095-4dannjjm 2363 10 lungs lung NNS cord-023095-4dannjjm 2363 11 on on IN cord-023095-4dannjjm 2363 12 ultrasound ultrasound NN cord-023095-4dannjjm 2363 13 were be VBD cord-023095-4dannjjm 2363 14 treated treat VBN cord-023095-4dannjjm 2363 15 with with IN cord-023095-4dannjjm 2363 16 antibiotics antibiotic NNS cord-023095-4dannjjm 2363 17 within within IN cord-023095-4dannjjm 2363 18 7 7 CD cord-023095-4dannjjm 2363 19 days day NNS cord-023095-4dannjjm 2363 20 of of IN cord-023095-4dannjjm 2363 21 examination examination NN cord-023095-4dannjjm 2363 22 . . . cord-023095-4dannjjm 2364 1 This this DT cord-023095-4dannjjm 2364 2 study study NN cord-023095-4dannjjm 2364 3 demonstrates demonstrate VBZ cord-023095-4dannjjm 2364 4 a a DT cord-023095-4dannjjm 2364 5 high high JJ cord-023095-4dannjjm 2364 6 prevalence prevalence NN cord-023095-4dannjjm 2364 7 of of IN cord-023095-4dannjjm 2364 8 abnormal abnormal JJ cord-023095-4dannjjm 2364 9 lungs lung NNS cord-023095-4dannjjm 2364 10 , , , cord-023095-4dannjjm 2364 11 as as IN cord-023095-4dannjjm 2364 12 detected detect VBN cord-023095-4dannjjm 2364 13 by by IN cord-023095-4dannjjm 2364 14 thoracic thoracic JJ cord-023095-4dannjjm 2364 15 ultrasonography ultrasonography NN cord-023095-4dannjjm 2364 16 , , , cord-023095-4dannjjm 2364 17 without without IN cord-023095-4dannjjm 2364 18 significant significant JJ cord-023095-4dannjjm 2364 19 clinical clinical JJ cord-023095-4dannjjm 2364 20 signs sign NNS cord-023095-4dannjjm 2364 21 in in IN cord-023095-4dannjjm 2364 22 pre pre JJ cord-023095-4dannjjm 2364 23 - - JJ cord-023095-4dannjjm 2364 24 weaned wean VBN cord-023095-4dannjjm 2364 25 dairy dairy NN cord-023095-4dannjjm 2364 26 calves calf NNS cord-023095-4dannjjm 2364 27 . . . cord-023095-4dannjjm 2365 1 The the DT cord-023095-4dannjjm 2365 2 relatively relatively RB cord-023095-4dannjjm 2365 3 low low JJ cord-023095-4dannjjm 2365 4 treatment treatment NN cord-023095-4dannjjm 2365 5 rate rate NN cord-023095-4dannjjm 2365 6 in in IN cord-023095-4dannjjm 2365 7 these these DT cord-023095-4dannjjm 2365 8 calves calf NNS cord-023095-4dannjjm 2365 9 may may MD cord-023095-4dannjjm 2365 10 suggest suggest VB cord-023095-4dannjjm 2365 11 an an DT cord-023095-4dannjjm 2365 12 area area NN cord-023095-4dannjjm 2365 13 of of IN cord-023095-4dannjjm 2365 14 opportunity opportunity NN cord-023095-4dannjjm 2365 15 for for IN cord-023095-4dannjjm 2365 16 improvement improvement NN cord-023095-4dannjjm 2365 17 in in IN cord-023095-4dannjjm 2365 18 calf calf NN cord-023095-4dannjjm 2365 19 health health NN cord-023095-4dannjjm 2365 20 , , , cord-023095-4dannjjm 2365 21 welfare welfare NN cord-023095-4dannjjm 2365 22 , , , cord-023095-4dannjjm 2365 23 and and CC cord-023095-4dannjjm 2365 24 herd herd NN cord-023095-4dannjjm 2365 25 longevity longevity NN cord-023095-4dannjjm 2365 26 . . . cord-023095-4dannjjm 2366 1 Further further JJ cord-023095-4dannjjm 2366 2 studies study NNS cord-023095-4dannjjm 2366 3 and and CC cord-023095-4dannjjm 2366 4 follow follow VB cord-023095-4dannjjm 2366 5 up up RP cord-023095-4dannjjm 2366 6 are be VBP cord-023095-4dannjjm 2366 7 needed need VBN cord-023095-4dannjjm 2366 8 to to TO cord-023095-4dannjjm 2366 9 elucidate elucidate VB cord-023095-4dannjjm 2366 10 the the DT cord-023095-4dannjjm 2366 11 significance significance NN cord-023095-4dannjjm 2366 12 of of IN cord-023095-4dannjjm 2366 13 these these DT cord-023095-4dannjjm 2366 14 findings finding NNS cord-023095-4dannjjm 2366 15 and and CC cord-023095-4dannjjm 2366 16 whether whether IN cord-023095-4dannjjm 2366 17 or or CC cord-023095-4dannjjm 2366 18 not not RB cord-023095-4dannjjm 2366 19 treatment treatment NN cord-023095-4dannjjm 2366 20 is be VBZ cord-023095-4dannjjm 2366 21 indicated indicate VBN cord-023095-4dannjjm 2366 22 . . . cord-023095-4dannjjm 2367 1 Literature literature NN cord-023095-4dannjjm 2367 2 regarding regard VBG cord-023095-4dannjjm 2367 3 diseases disease NNS cord-023095-4dannjjm 2367 4 causing cause VBG cord-023095-4dannjjm 2367 5 lameness lameness NN cord-023095-4dannjjm 2367 6 in in IN cord-023095-4dannjjm 2367 7 beef beef NN cord-023095-4dannjjm 2367 8 cattle cattle NNS cord-023095-4dannjjm 2367 9 is be VBZ cord-023095-4dannjjm 2367 10 limited limited JJ cord-023095-4dannjjm 2367 11 . . . cord-023095-4dannjjm 2368 1 This this DT cord-023095-4dannjjm 2368 2 retrospective retrospective JJ cord-023095-4dannjjm 2368 3 study study NN cord-023095-4dannjjm 2368 4 was be VBD cord-023095-4dannjjm 2368 5 undertaken undertake VBN cord-023095-4dannjjm 2368 6 to to TO cord-023095-4dannjjm 2368 7 examine examine VB cord-023095-4dannjjm 2368 8 beef beef NN cord-023095-4dannjjm 2368 9 cattle cattle NNS cord-023095-4dannjjm 2368 10 presented present VBN cord-023095-4dannjjm 2368 11 for for IN cord-023095-4dannjjm 2368 12 lameness lameness NN cord-023095-4dannjjm 2368 13 . . . cord-023095-4dannjjm 2369 1 Medical medical JJ cord-023095-4dannjjm 2369 2 records record NNS cord-023095-4dannjjm 2369 3 of of IN cord-023095-4dannjjm 2369 4 beef beef NN cord-023095-4dannjjm 2369 5 cattle cattle NNS cord-023095-4dannjjm 2369 6 having have VBG cord-023095-4dannjjm 2369 7 a a DT cord-023095-4dannjjm 2369 8 lameness lameness NN cord-023095-4dannjjm 2369 9 examination examination NN cord-023095-4dannjjm 2369 10 done do VBN cord-023095-4dannjjm 2369 11 during during IN cord-023095-4dannjjm 2369 12 the the DT cord-023095-4dannjjm 2369 13 period period NN cord-023095-4dannjjm 2369 14 2007 2007 CD cord-023095-4dannjjm 2369 15 to to IN cord-023095-4dannjjm 2369 16 2010 2010 CD cord-023095-4dannjjm 2369 17 were be VBD cord-023095-4dannjjm 2369 18 reviewed review VBN cord-023095-4dannjjm 2369 19 and and CC cord-023095-4dannjjm 2369 20 descriptive descriptive JJ cord-023095-4dannjjm 2369 21 statistics statistic NNS cord-023095-4dannjjm 2369 22 generated generate VBN cord-023095-4dannjjm 2369 23 . . . cord-023095-4dannjjm 2370 1 Lameness lameness NN cord-023095-4dannjjm 2370 2 was be VBD cord-023095-4dannjjm 2370 3 classified classify VBN cord-023095-4dannjjm 2370 4 based base VBN cord-023095-4dannjjm 2370 5 on on IN cord-023095-4dannjjm 2370 6 clinical clinical JJ cord-023095-4dannjjm 2370 7 diagnosis diagnosis NN cord-023095-4dannjjm 2370 8 . . . cord-023095-4dannjjm 2371 1 The the DT cord-023095-4dannjjm 2371 2 medical medical JJ cord-023095-4dannjjm 2371 3 records record NNS cord-023095-4dannjjm 2371 4 of of IN cord-023095-4dannjjm 2371 5 270 270 CD cord-023095-4dannjjm 2371 6 beef beef NN cord-023095-4dannjjm 2371 7 cattle cattle NNS cord-023095-4dannjjm 2371 8 were be VBD cord-023095-4dannjjm 2371 9 reviewed review VBN cord-023095-4dannjjm 2371 10 of of IN cord-023095-4dannjjm 2371 11 which which WDT cord-023095-4dannjjm 2371 12 63.2 63.2 CD cord-023095-4dannjjm 2371 13 % % NN cord-023095-4dannjjm 2371 14 were be VBD cord-023095-4dannjjm 2371 15 male male JJ cord-023095-4dannjjm 2371 16 and and CC cord-023095-4dannjjm 2371 17 36.8 36.8 CD cord-023095-4dannjjm 2371 18 % % NN cord-023095-4dannjjm 2371 19 were be VBD cord-023095-4dannjjm 2371 20 female female JJ cord-023095-4dannjjm 2371 21 . . . cord-023095-4dannjjm 2372 1 Beef beef NN cord-023095-4dannjjm 2372 2 cattle cattle NNS cord-023095-4dannjjm 2372 3 presented present VBN cord-023095-4dannjjm 2372 4 for for IN cord-023095-4dannjjm 2372 5 lameness lameness NN cord-023095-4dannjjm 2372 6 most most RBS cord-023095-4dannjjm 2372 7 often often RB cord-023095-4dannjjm 2372 8 during during IN cord-023095-4dannjjm 2372 9 the the DT cord-023095-4dannjjm 2372 10 summer summer NN cord-023095-4dannjjm 2372 11 months month NNS cord-023095-4dannjjm 2372 12 ( ( -LRB- cord-023095-4dannjjm 2372 13 34 34 CD cord-023095-4dannjjm 2372 14 % % NN cord-023095-4dannjjm 2372 15 ) ) -RRB- cord-023095-4dannjjm 2372 16 and and CC cord-023095-4dannjjm 2372 17 least least JJS cord-023095-4dannjjm 2372 18 during during IN cord-023095-4dannjjm 2372 19 autumn autumn NN cord-023095-4dannjjm 2372 20 ( ( -LRB- cord-023095-4dannjjm 2372 21 18 18 CD cord-023095-4dannjjm 2372 22 % % NN cord-023095-4dannjjm 2372 23 ) ) -RRB- cord-023095-4dannjjm 2372 24 . . . cord-023095-4dannjjm 2373 1 Causes cause NNS cord-023095-4dannjjm 2373 2 of of IN cord-023095-4dannjjm 2373 3 lameness lameness NN cord-023095-4dannjjm 2373 4 were be VBD cord-023095-4dannjjm 2373 5 categorized categorize VBN cord-023095-4dannjjm 2373 6 as as IN cord-023095-4dannjjm 2373 7 infectious infectious JJ cord-023095-4dannjjm 2373 8 ( ( -LRB- cord-023095-4dannjjm 2373 9 44.6 44.6 CD cord-023095-4dannjjm 2373 10 % % NN cord-023095-4dannjjm 2373 11 ) ) -RRB- cord-023095-4dannjjm 2373 12 or or CC cord-023095-4dannjjm 2373 13 non non JJ cord-023095-4dannjjm 2373 14 - - JJ cord-023095-4dannjjm 2373 15 infectious infectious JJ cord-023095-4dannjjm 2373 16 ( ( -LRB- cord-023095-4dannjjm 2373 17 55.4 55.4 CD cord-023095-4dannjjm 2373 18 % % NN cord-023095-4dannjjm 2373 19 ) ) -RRB- cord-023095-4dannjjm 2373 20 and and CC cord-023095-4dannjjm 2373 21 infectious infectious JJ cord-023095-4dannjjm 2373 22 lameness lameness NN cord-023095-4dannjjm 2373 23 subcategorized subcategorize VBN cord-023095-4dannjjm 2373 24 as as IN cord-023095-4dannjjm 2373 25 either either CC cord-023095-4dannjjm 2373 26 a a DT cord-023095-4dannjjm 2373 27 primary primary JJ cord-023095-4dannjjm 2373 28 disorder disorder NN cord-023095-4dannjjm 2373 29 or or CC cord-023095-4dannjjm 2373 30 a a DT cord-023095-4dannjjm 2373 31 secondary secondary JJ cord-023095-4dannjjm 2373 32 infection infection NN cord-023095-4dannjjm 2373 33 . . . cord-023095-4dannjjm 2374 1 All all DT cord-023095-4dannjjm 2374 2 cases case NNS cord-023095-4dannjjm 2374 3 of of IN cord-023095-4dannjjm 2374 4 a a DT cord-023095-4dannjjm 2374 5 primary primary JJ cord-023095-4dannjjm 2374 6 infectious infectious JJ cord-023095-4dannjjm 2374 7 disorder disorder NN cord-023095-4dannjjm 2374 8 were be VBD cord-023095-4dannjjm 2374 9 interdigital interdigital NNP cord-023095-4dannjjm 2374 10 phlegmon phlegmon NNP cord-023095-4dannjjm 2374 11 . . . cord-023095-4dannjjm 2375 1 Secondary secondary JJ cord-023095-4dannjjm 2375 2 infections infection NNS cord-023095-4dannjjm 2375 3 diseases disease NNS cord-023095-4dannjjm 2375 4 included include VBD cord-023095-4dannjjm 2375 5 sole sole JJ cord-023095-4dannjjm 2375 6 abscess abscess NN cord-023095-4dannjjm 2375 7 ( ( -LRB- cord-023095-4dannjjm 2375 8 25.9 25.9 CD cord-023095-4dannjjm 2375 9 % % NN cord-023095-4dannjjm 2375 10 ) ) -RRB- cord-023095-4dannjjm 2375 11 , , , cord-023095-4dannjjm 2375 12 septic septic JJ cord-023095-4dannjjm 2375 13 arthritis arthritis NN cord-023095-4dannjjm 2375 14 ( ( -LRB- cord-023095-4dannjjm 2375 15 11.1 11.1 CD cord-023095-4dannjjm 2375 16 % % NN cord-023095-4dannjjm 2375 17 ) ) -RRB- cord-023095-4dannjjm 2375 18 , , , cord-023095-4dannjjm 2375 19 tenosynovitis tenosynovitis NNP cord-023095-4dannjjm 2375 20 ( ( -LRB- cord-023095-4dannjjm 2375 21 2.8 2.8 CD cord-023095-4dannjjm 2375 22 % % NN cord-023095-4dannjjm 2375 23 ) ) -RRB- cord-023095-4dannjjm 2375 24 , , , cord-023095-4dannjjm 2375 25 and and CC cord-023095-4dannjjm 2375 26 pedal pedal NN cord-023095-4dannjjm 2375 27 osteitis osteitis NNP cord-023095-4dannjjm 2375 28 ( ( -LRB- cord-023095-4dannjjm 2375 29 1.3 1.3 CD cord-023095-4dannjjm 2375 30 % % NN cord-023095-4dannjjm 2375 31 ) ) -RRB- cord-023095-4dannjjm 2375 32 . . . cord-023095-4dannjjm 2376 1 Non non JJ cord-023095-4dannjjm 2376 2 - - JJ cord-023095-4dannjjm 2376 3 infectious infectious JJ cord-023095-4dannjjm 2376 4 lameness lameness NN cord-023095-4dannjjm 2376 5 included include VBD cord-023095-4dannjjm 2376 6 proximal proximal JJ cord-023095-4dannjjm 2376 7 limb limb NN cord-023095-4dannjjm 2376 8 lameness lameness NN cord-023095-4dannjjm 2376 9 ( ( -LRB- cord-023095-4dannjjm 2376 10 19.6 19.6 CD cord-023095-4dannjjm 2376 11 % % NN cord-023095-4dannjjm 2376 12 ) ) -RRB- cord-023095-4dannjjm 2376 13 , , , cord-023095-4dannjjm 2376 14 foot foot NN cord-023095-4dannjjm 2376 15 trauma trauma NN cord-023095-4dannjjm 2376 16 ( ( -LRB- cord-023095-4dannjjm 2376 17 14.6 14.6 CD cord-023095-4dannjjm 2376 18 % % NN cord-023095-4dannjjm 2376 19 ) ) -RRB- cord-023095-4dannjjm 2376 20 , , , cord-023095-4dannjjm 2376 21 hoof hoof NN cord-023095-4dannjjm 2376 22 horn horn NN cord-023095-4dannjjm 2376 23 cracks crack NNS cord-023095-4dannjjm 2376 24 ( ( -LRB- cord-023095-4dannjjm 2376 25 9.5 9.5 CD cord-023095-4dannjjm 2376 26 % % NN cord-023095-4dannjjm 2376 27 ) ) -RRB- cord-023095-4dannjjm 2376 28 , , , cord-023095-4dannjjm 2376 29 hoof hoof NN cord-023095-4dannjjm 2376 30 defects defect NNS cord-023095-4dannjjm 2376 31 ( ( -LRB- cord-023095-4dannjjm 2376 32 2.5 2.5 CD cord-023095-4dannjjm 2376 33 % % NN cord-023095-4dannjjm 2376 34 ) ) -RRB- cord-023095-4dannjjm 2376 35 , , , cord-023095-4dannjjm 2376 36 interdigital interdigital NNP cord-023095-4dannjjm 2376 37 fibromas fibromas NNP cord-023095-4dannjjm 2376 38 ( ( -LRB- cord-023095-4dannjjm 2376 39 1.9 1.9 CD cord-023095-4dannjjm 2376 40 % % NN cord-023095-4dannjjm 2376 41 ) ) -RRB- cord-023095-4dannjjm 2376 42 , , , cord-023095-4dannjjm 2376 43 overgrown overgrown JJ cord-023095-4dannjjm 2376 44 hooves hoof NNS cord-023095-4dannjjm 2376 45 ( ( -LRB- cord-023095-4dannjjm 2376 46 1.9 1.9 CD cord-023095-4dannjjm 2376 47 % % NN cord-023095-4dannjjm 2376 48 ) ) -RRB- cord-023095-4dannjjm 2376 49 , , , cord-023095-4dannjjm 2376 50 sole sole JJ cord-023095-4dannjjm 2376 51 bruise bruise NN cord-023095-4dannjjm 2376 52 ( ( -LRB- cord-023095-4dannjjm 2376 53 1.3 1.3 CD cord-023095-4dannjjm 2376 54 % % NN cord-023095-4dannjjm 2376 55 ) ) -RRB- cord-023095-4dannjjm 2376 56 , , , cord-023095-4dannjjm 2376 57 subclinical subclinical JJ cord-023095-4dannjjm 2376 58 laminitis laminitis NN cord-023095-4dannjjm 2376 59 ( ( -LRB- cord-023095-4dannjjm 2376 60 1.3 1.3 CD cord-023095-4dannjjm 2376 61 % % NN cord-023095-4dannjjm 2376 62 ) ) -RRB- cord-023095-4dannjjm 2376 63 , , , cord-023095-4dannjjm 2376 64 white white JJ cord-023095-4dannjjm 2376 65 line line NN cord-023095-4dannjjm 2376 66 disease disease NN cord-023095-4dannjjm 2376 67 ( ( -LRB- cord-023095-4dannjjm 2376 68 0.9 0.9 CD cord-023095-4dannjjm 2376 69 % % NN cord-023095-4dannjjm 2376 70 ) ) -RRB- cord-023095-4dannjjm 2376 71 , , , cord-023095-4dannjjm 2376 72 osteoarthritis osteoarthritis NN cord-023095-4dannjjm 2376 73 ( ( -LRB- cord-023095-4dannjjm 2376 74 0.9 0.9 CD cord-023095-4dannjjm 2376 75 % % NN cord-023095-4dannjjm 2376 76 ) ) -RRB- cord-023095-4dannjjm 2376 77 , , , cord-023095-4dannjjm 2376 78 heel heel NN cord-023095-4dannjjm 2376 79 erosion erosion NN cord-023095-4dannjjm 2376 80 ( ( -LRB- cord-023095-4dannjjm 2376 81 0.3 0.3 CD cord-023095-4dannjjm 2376 82 % % NN cord-023095-4dannjjm 2376 83 ) ) -RRB- cord-023095-4dannjjm 2376 84 , , , cord-023095-4dannjjm 2376 85 sole sole JJ cord-023095-4dannjjm 2376 86 ulcers ulcer NNS cord-023095-4dannjjm 2376 87 ( ( -LRB- cord-023095-4dannjjm 2376 88 0.3 0.3 CD cord-023095-4dannjjm 2376 89 % % NN cord-023095-4dannjjm 2376 90 ) ) -RRB- cord-023095-4dannjjm 2376 91 , , , cord-023095-4dannjjm 2376 92 and and CC cord-023095-4dannjjm 2376 93 sole sole JJ cord-023095-4dannjjm 2376 94 hemorrhage hemorrhage NN cord-023095-4dannjjm 2376 95 ( ( -LRB- cord-023095-4dannjjm 2376 96 0.3 0.3 CD cord-023095-4dannjjm 2376 97 % % NN cord-023095-4dannjjm 2376 98 ) ) -RRB- cord-023095-4dannjjm 2376 99 . . . cord-023095-4dannjjm 2377 1 The the DT cord-023095-4dannjjm 2377 2 most most RBS cord-023095-4dannjjm 2377 3 frequently frequently RB cord-023095-4dannjjm 2377 4 affected affect VBN cord-023095-4dannjjm 2377 5 claw claw NN cord-023095-4dannjjm 2377 6 was be VBD cord-023095-4dannjjm 2377 7 the the DT cord-023095-4dannjjm 2377 8 lateral lateral JJ cord-023095-4dannjjm 2377 9 digit digit NN cord-023095-4dannjjm 2377 10 of of IN cord-023095-4dannjjm 2377 11 the the DT cord-023095-4dannjjm 2377 12 hind hind NN cord-023095-4dannjjm 2377 13 limb limb NN cord-023095-4dannjjm 2377 14 ( ( -LRB- cord-023095-4dannjjm 2377 15 36.4 36.4 CD cord-023095-4dannjjm 2377 16 % % NN cord-023095-4dannjjm 2377 17 ) ) -RRB- cord-023095-4dannjjm 2377 18 , , , cord-023095-4dannjjm 2377 19 followed follow VBN cord-023095-4dannjjm 2377 20 by by IN cord-023095-4dannjjm 2377 21 the the DT cord-023095-4dannjjm 2377 22 medial medial JJ cord-023095-4dannjjm 2377 23 digit digit NN cord-023095-4dannjjm 2377 24 of of IN cord-023095-4dannjjm 2377 25 the the DT cord-023095-4dannjjm 2377 26 front front JJ cord-023095-4dannjjm 2377 27 limb limb NN cord-023095-4dannjjm 2377 28 ( ( -LRB- cord-023095-4dannjjm 2377 29 27.1 27.1 CD cord-023095-4dannjjm 2377 30 % % NN cord-023095-4dannjjm 2377 31 ) ) -RRB- cord-023095-4dannjjm 2377 32 , , , cord-023095-4dannjjm 2377 33 lateral lateral JJ cord-023095-4dannjjm 2377 34 digit digit NN cord-023095-4dannjjm 2377 35 of of IN cord-023095-4dannjjm 2377 36 the the DT cord-023095-4dannjjm 2377 37 front front JJ cord-023095-4dannjjm 2377 38 limb limb NN cord-023095-4dannjjm 2377 39 ( ( -LRB- cord-023095-4dannjjm 2377 40 23.6 23.6 CD cord-023095-4dannjjm 2377 41 % % NN cord-023095-4dannjjm 2377 42 ) ) -RRB- cord-023095-4dannjjm 2377 43 , , , cord-023095-4dannjjm 2377 44 and and CC cord-023095-4dannjjm 2377 45 the the DT cord-023095-4dannjjm 2377 46 medial medial JJ cord-023095-4dannjjm 2377 47 digit digit NN cord-023095-4dannjjm 2377 48 of of IN cord-023095-4dannjjm 2377 49 the the DT cord-023095-4dannjjm 2377 50 hind hind NN cord-023095-4dannjjm 2377 51 limb limb NN cord-023095-4dannjjm 2377 52 ( ( -LRB- cord-023095-4dannjjm 2377 53 12.9 12.9 CD cord-023095-4dannjjm 2377 54 % % NN cord-023095-4dannjjm 2377 55 ) ) -RRB- cord-023095-4dannjjm 2377 56 . . . cord-023095-4dannjjm 2378 1 The the DT cord-023095-4dannjjm 2378 2 findings finding NNS cord-023095-4dannjjm 2378 3 of of IN cord-023095-4dannjjm 2378 4 this this DT cord-023095-4dannjjm 2378 5 study study NN cord-023095-4dannjjm 2378 6 suggest suggest VBP cord-023095-4dannjjm 2378 7 significant significant JJ cord-023095-4dannjjm 2378 8 differences difference NNS cord-023095-4dannjjm 2378 9 in in IN cord-023095-4dannjjm 2378 10 the the DT cord-023095-4dannjjm 2378 11 frequency frequency NN cord-023095-4dannjjm 2378 12 of of IN cord-023095-4dannjjm 2378 13 disease disease NN cord-023095-4dannjjm 2378 14 causing cause VBG cord-023095-4dannjjm 2378 15 lameness lameness NN cord-023095-4dannjjm 2378 16 in in IN cord-023095-4dannjjm 2378 17 beef beef NN cord-023095-4dannjjm 2378 18 cattle cattle NNS cord-023095-4dannjjm 2378 19 compared compare VBN cord-023095-4dannjjm 2378 20 to to IN cord-023095-4dannjjm 2378 21 published publish VBN cord-023095-4dannjjm 2378 22 reports report NNS cord-023095-4dannjjm 2378 23 for for IN cord-023095-4dannjjm 2378 24 dairy dairy NN cord-023095-4dannjjm 2378 25 cattle cattle NNS cord-023095-4dannjjm 2378 26 . . . cord-023095-4dannjjm 2379 1 In in IN cord-023095-4dannjjm 2379 2 people people NNS cord-023095-4dannjjm 2379 3 , , , cord-023095-4dannjjm 2379 4 endoscopic endoscopic NNS cord-023095-4dannjjm 2379 5 ultrasound ultrasound NN cord-023095-4dannjjm 2379 6 ( ( -LRB- cord-023095-4dannjjm 2379 7 EUS EUS NNP cord-023095-4dannjjm 2379 8 ) ) -RRB- cord-023095-4dannjjm 2379 9 has have VBZ cord-023095-4dannjjm 2379 10 become become VBN cord-023095-4dannjjm 2379 11 the the DT cord-023095-4dannjjm 2379 12 technique technique NN cord-023095-4dannjjm 2379 13 of of IN cord-023095-4dannjjm 2379 14 choice choice NN cord-023095-4dannjjm 2379 15 for for IN cord-023095-4dannjjm 2379 16 assessing assess VBG cord-023095-4dannjjm 2379 17 pancreatic pancreatic JJ cord-023095-4dannjjm 2379 18 disease disease NN cord-023095-4dannjjm 2379 19 and and CC cord-023095-4dannjjm 2379 20 EUS eus NN cord-023095-4dannjjm 2379 21 - - HYPH cord-023095-4dannjjm 2379 22 guided guide VBN cord-023095-4dannjjm 2379 23 fineneedle fineneedle NN cord-023095-4dannjjm 2379 24 aspiration aspiration NN cord-023095-4dannjjm 2379 25 ( ( -LRB- cord-023095-4dannjjm 2379 26 EUS EUS NNP cord-023095-4dannjjm 2379 27 FNA FNA NNP cord-023095-4dannjjm 2379 28 ) ) -RRB- cord-023095-4dannjjm 2379 29 has have VBZ cord-023095-4dannjjm 2379 30 proven prove VBN cord-023095-4dannjjm 2379 31 a a DT cord-023095-4dannjjm 2379 32 useful useful JJ cord-023095-4dannjjm 2379 33 and and CC cord-023095-4dannjjm 2379 34 safe safe JJ cord-023095-4dannjjm 2379 35 modality modality NN cord-023095-4dannjjm 2379 36 for for IN cord-023095-4dannjjm 2379 37 characterizing characterize VBG cord-023095-4dannjjm 2379 38 pancreatic pancreatic JJ cord-023095-4dannjjm 2379 39 lesions lesion NNS cord-023095-4dannjjm 2379 40 . . . cord-023095-4dannjjm 2380 1 Reported report VBN cord-023095-4dannjjm 2380 2 complications complication NNS cord-023095-4dannjjm 2380 3 include include VBP cord-023095-4dannjjm 2380 4 infections infection NNS cord-023095-4dannjjm 2380 5 , , , cord-023095-4dannjjm 2380 6 bleeding bleed VBG cord-023095-4dannjjm 2380 7 and and CC cord-023095-4dannjjm 2380 8 acute acute JJ cord-023095-4dannjjm 2380 9 pancreatitis pancreatitis NN cord-023095-4dannjjm 2380 10 . . . cord-023095-4dannjjm 2381 1 In in IN cord-023095-4dannjjm 2381 2 dogs dog NNS cord-023095-4dannjjm 2381 3 , , , cord-023095-4dannjjm 2381 4 laparoscopic laparoscopic JJ cord-023095-4dannjjm 2381 5 - - HYPH cord-023095-4dannjjm 2381 6 assisted assist VBN cord-023095-4dannjjm 2381 7 pancreatic pancreatic JJ cord-023095-4dannjjm 2381 8 biopsy biopsy NN cord-023095-4dannjjm 2381 9 has have VBZ cord-023095-4dannjjm 2381 10 been be VBN cord-023095-4dannjjm 2381 11 suggested suggest VBN cord-023095-4dannjjm 2381 12 to to TO cord-023095-4dannjjm 2381 13 be be VB cord-023095-4dannjjm 2381 14 a a DT cord-023095-4dannjjm 2381 15 safe safe JJ cord-023095-4dannjjm 2381 16 procedure procedure NN cord-023095-4dannjjm 2381 17 , , , cord-023095-4dannjjm 2381 18 however however RB cord-023095-4dannjjm 2381 19 EUS eus NN cord-023095-4dannjjm 2381 20 and and CC cord-023095-4dannjjm 2381 21 EUS EUS NNP cord-023095-4dannjjm 2381 22 FNA FNA NNP cord-023095-4dannjjm 2381 23 have have VBP cord-023095-4dannjjm 2381 24 not not RB cord-023095-4dannjjm 2381 25 been be VBN cord-023095-4dannjjm 2381 26 evaluated evaluate VBN cord-023095-4dannjjm 2381 27 in in IN cord-023095-4dannjjm 2381 28 dogs dog NNS cord-023095-4dannjjm 2381 29 so so RB cord-023095-4dannjjm 2381 30 far far RB cord-023095-4dannjjm 2381 31 . . . cord-023095-4dannjjm 2382 1 Thus thus RB cord-023095-4dannjjm 2382 2 the the DT cord-023095-4dannjjm 2382 3 aim aim NN cord-023095-4dannjjm 2382 4 of of IN cord-023095-4dannjjm 2382 5 the the DT cord-023095-4dannjjm 2382 6 present present JJ cord-023095-4dannjjm 2382 7 study study NN cord-023095-4dannjjm 2382 8 was be VBD cord-023095-4dannjjm 2382 9 to to TO cord-023095-4dannjjm 2382 10 assess assess VB cord-023095-4dannjjm 2382 11 the the DT cord-023095-4dannjjm 2382 12 practicability practicability NN cord-023095-4dannjjm 2382 13 and and CC cord-023095-4dannjjm 2382 14 safety safety NN cord-023095-4dannjjm 2382 15 of of IN cord-023095-4dannjjm 2382 16 EUS eus NN cord-023095-4dannjjm 2382 17 examination examination NN cord-023095-4dannjjm 2382 18 of of IN cord-023095-4dannjjm 2382 19 the the DT cord-023095-4dannjjm 2382 20 abdominal abdominal JJ cord-023095-4dannjjm 2382 21 cavity cavity NN cord-023095-4dannjjm 2382 22 as as RB cord-023095-4dannjjm 2382 23 well well RB cord-023095-4dannjjm 2382 24 as as IN cord-023095-4dannjjm 2382 25 pancreatic pancreatic NN cord-023095-4dannjjm 2382 26 EUS eus NN cord-023095-4dannjjm 2382 27 FNA FNA NNP cord-023095-4dannjjm 2382 28 in in IN cord-023095-4dannjjm 2382 29 healthy healthy JJ cord-023095-4dannjjm 2382 30 dogs dog NNS cord-023095-4dannjjm 2382 31 . . . cord-023095-4dannjjm 2383 1 This this DT cord-023095-4dannjjm 2383 2 study study NN cord-023095-4dannjjm 2383 3 was be VBD cord-023095-4dannjjm 2383 4 approved approve VBN cord-023095-4dannjjm 2383 5 by by IN cord-023095-4dannjjm 2383 6 the the DT cord-023095-4dannjjm 2383 7 Cantonal Cantonal NNP cord-023095-4dannjjm 2383 8 Committee Committee NNP cord-023095-4dannjjm 2383 9 for for IN cord-023095-4dannjjm 2383 10 the the DT cord-023095-4dannjjm 2383 11 Authorization Authorization NNP cord-023095-4dannjjm 2383 12 of of IN cord-023095-4dannjjm 2383 13 Animal Animal NNP cord-023095-4dannjjm 2383 14 Experimentation Experimentation NNP cord-023095-4dannjjm 2383 15 , , , cord-023095-4dannjjm 2383 16 Zurich Zurich NNP cord-023095-4dannjjm 2383 17 , , , cord-023095-4dannjjm 2383 18 Switzerland Switzerland NNP cord-023095-4dannjjm 2383 19 . . . cord-023095-4dannjjm 2384 1 The the DT cord-023095-4dannjjm 2384 2 study study NN cord-023095-4dannjjm 2384 3 population population NN cord-023095-4dannjjm 2384 4 consisted consist VBD cord-023095-4dannjjm 2384 5 of of IN cord-023095-4dannjjm 2384 6 14 14 CD cord-023095-4dannjjm 2384 7 healthy healthy JJ cord-023095-4dannjjm 2384 8 beagle beagle NN cord-023095-4dannjjm 2384 9 dogs dog NNS cord-023095-4dannjjm 2384 10 with with IN cord-023095-4dannjjm 2384 11 a a DT cord-023095-4dannjjm 2384 12 median median JJ cord-023095-4dannjjm 2384 13 bodyweight bodyweight NN cord-023095-4dannjjm 2384 14 of of IN cord-023095-4dannjjm 2384 15 13.4 13.4 CD cord-023095-4dannjjm 2384 16 kg kg NNS cord-023095-4dannjjm 2384 17 ( ( -LRB- cord-023095-4dannjjm 2384 18 10.9 10.9 CD cord-023095-4dannjjm 2384 19 - - SYM cord-023095-4dannjjm 2384 20 15.7 15.7 CD cord-023095-4dannjjm 2384 21 ) ) -RRB- cord-023095-4dannjjm 2384 22 . . . cord-023095-4dannjjm 2385 1 EUS EUS NNP cord-023095-4dannjjm 2385 2 was be VBD cord-023095-4dannjjm 2385 3 performed perform VBN cord-023095-4dannjjm 2385 4 with with IN cord-023095-4dannjjm 2385 5 an an DT cord-023095-4dannjjm 2385 6 Olympus Olympus NNP cord-023095-4dannjjm 2385 7 GF GF NNP cord-023095-4dannjjm 2385 8 - - HYPH cord-023095-4dannjjm 2385 9 UC140P uc140p NN cord-023095-4dannjjm 2385 10 - - HYPH cord-023095-4dannjjm 2385 11 echoendoscope echoendoscope NN cord-023095-4dannjjm 2385 12 and and CC cord-023095-4dannjjm 2385 13 FNA FNA NNP cord-023095-4dannjjm 2385 14 were be VBD cord-023095-4dannjjm 2385 15 performed perform VBN cord-023095-4dannjjm 2385 16 using use VBG cord-023095-4dannjjm 2385 17 19 19 CD cord-023095-4dannjjm 2385 18 G g NN cord-023095-4dannjjm 2385 19 needles needle NNS cord-023095-4dannjjm 2385 20 ( ( -LRB- cord-023095-4dannjjm 2385 21 Cook Cook NNP cord-023095-4dannjjm 2385 22 EchoTipUltra EchoTipUltra NNP cord-023095-4dannjjm 2385 23 ) ) -RRB- cord-023095-4dannjjm 2385 24 . . . cord-023095-4dannjjm 2386 1 After after IN cord-023095-4dannjjm 2386 2 completion completion NN cord-023095-4dannjjm 2386 3 of of IN cord-023095-4dannjjm 2386 4 the the DT cord-023095-4dannjjm 2386 5 EUS eus NN cord-023095-4dannjjm 2386 6 - - HYPH cord-023095-4dannjjm 2386 7 examination examination NN cord-023095-4dannjjm 2386 8 of of IN cord-023095-4dannjjm 2386 9 the the DT cord-023095-4dannjjm 2386 10 abdominal abdominal JJ cord-023095-4dannjjm 2386 11 cavity cavity NN cord-023095-4dannjjm 2386 12 from from IN cord-023095-4dannjjm 2386 13 the the DT cord-023095-4dannjjm 2386 14 stomach stomach NN cord-023095-4dannjjm 2386 15 ( ( -LRB- cord-023095-4dannjjm 2386 16 liver liver NN cord-023095-4dannjjm 2386 17 , , , cord-023095-4dannjjm 2386 18 gallbladder gallbladder NN cord-023095-4dannjjm 2386 19 , , , cord-023095-4dannjjm 2386 20 bile bile NN cord-023095-4dannjjm 2386 21 ducts duct NNS cord-023095-4dannjjm 2386 22 , , , cord-023095-4dannjjm 2386 23 kidneys kidney NNS cord-023095-4dannjjm 2386 24 , , , cord-023095-4dannjjm 2386 25 adrenals adrenal NNS cord-023095-4dannjjm 2386 26 , , , cord-023095-4dannjjm 2386 27 pancreas pancrea NNS cord-023095-4dannjjm 2386 28 ) ) -RRB- cord-023095-4dannjjm 2386 29 , , , cord-023095-4dannjjm 2386 30 the the DT cord-023095-4dannjjm 2386 31 scope scope NN cord-023095-4dannjjm 2386 32 was be VBD cord-023095-4dannjjm 2386 33 advanced advance VBN cord-023095-4dannjjm 2386 34 into into IN cord-023095-4dannjjm 2386 35 the the DT cord-023095-4dannjjm 2386 36 duodenum duodenum NN cord-023095-4dannjjm 2386 37 and and CC cord-023095-4dannjjm 2386 38 EUS EUS NNP cord-023095-4dannjjm 2386 39 FNA FNA NNP cord-023095-4dannjjm 2386 40 of of IN cord-023095-4dannjjm 2386 41 the the DT cord-023095-4dannjjm 2386 42 pancreas pancreas NN cord-023095-4dannjjm 2386 43 was be VBD cord-023095-4dannjjm 2386 44 performed perform VBN cord-023095-4dannjjm 2386 45 . . . cord-023095-4dannjjm 2387 1 FNA FNA NNP cord-023095-4dannjjm 2387 2 tissue tissue NN cord-023095-4dannjjm 2387 3 acquisition acquisition NN cord-023095-4dannjjm 2387 4 was be VBD cord-023095-4dannjjm 2387 5 made make VBN cord-023095-4dannjjm 2387 6 applying apply VBG cord-023095-4dannjjm 2387 7 negative negative JJ cord-023095-4dannjjm 2387 8 pressure pressure NN cord-023095-4dannjjm 2387 9 and and CC cord-023095-4dannjjm 2387 10 6 6 CD cord-023095-4dannjjm 2387 11 to to TO cord-023095-4dannjjm 2387 12 8 8 CD cord-023095-4dannjjm 2387 13 needle needle NN cord-023095-4dannjjm 2387 14 passes pass NNS cord-023095-4dannjjm 2387 15 were be VBD cord-023095-4dannjjm 2387 16 made make VBN cord-023095-4dannjjm 2387 17 . . . cord-023095-4dannjjm 2388 1 All all DT cord-023095-4dannjjm 2388 2 dogs dog NNS cord-023095-4dannjjm 2388 3 received receive VBD cord-023095-4dannjjm 2388 4 30 30 CD cord-023095-4dannjjm 2388 5 mg mg NNP cord-023095-4dannjjm 2388 6 / / SYM cord-023095-4dannjjm 2388 7 kg kg NNP cord-023095-4dannjjm 2388 8 metimazole metimazole NN cord-023095-4dannjjm 2388 9 IM IM NNP cord-023095-4dannjjm 2388 10 after after IN cord-023095-4dannjjm 2388 11 EUS eus NN cord-023095-4dannjjm 2388 12 FNA FNA NNP cord-023095-4dannjjm 2388 13 and and CC cord-023095-4dannjjm 2388 14 were be VBD cord-023095-4dannjjm 2388 15 re re VBN cord-023095-4dannjjm 2388 16 - - VBN cord-023095-4dannjjm 2388 17 checked check VBN cord-023095-4dannjjm 2388 18 ultrasonographically ultrasonographically RB cord-023095-4dannjjm 2388 19 20 20 CD cord-023095-4dannjjm 2388 20 minutes minute NNS cord-023095-4dannjjm 2388 21 post post NN cord-023095-4dannjjm 2388 22 EUS eus NN cord-023095-4dannjjm 2388 23 FNA FNA NNP cord-023095-4dannjjm 2388 24 . . . cord-023095-4dannjjm 2389 1 Postoperative postoperative JJ cord-023095-4dannjjm 2389 2 activity activity NN cord-023095-4dannjjm 2389 3 was be VBD cord-023095-4dannjjm 2389 4 assessed assess VBN cord-023095-4dannjjm 2389 5 using use VBG cord-023095-4dannjjm 2389 6 a a DT cord-023095-4dannjjm 2389 7 standardized standardized JJ cord-023095-4dannjjm 2389 8 scoring scoring NN cord-023095-4dannjjm 2389 9 system system NN cord-023095-4dannjjm 2389 10 . . . cord-023095-4dannjjm 2390 1 A a DT cord-023095-4dannjjm 2390 2 CBC CBC NNP cord-023095-4dannjjm 2390 3 , , , cord-023095-4dannjjm 2390 4 serum serum NN cord-023095-4dannjjm 2390 5 biochemistry biochemistry NN cord-023095-4dannjjm 2390 6 , , , cord-023095-4dannjjm 2390 7 urinalysis urinalysis NN cord-023095-4dannjjm 2390 8 and and CC cord-023095-4dannjjm 2390 9 spec spec NN cord-023095-4dannjjm 2390 10 cPL cPL NNS cord-023095-4dannjjm 2390 11 s s NNPS cord-023095-4dannjjm 2390 12 were be VBD cord-023095-4dannjjm 2390 13 measured measure VBN cord-023095-4dannjjm 2390 14 before before RB cord-023095-4dannjjm 2390 15 , , , cord-023095-4dannjjm 2390 16 as as RB cord-023095-4dannjjm 2390 17 well well RB cord-023095-4dannjjm 2390 18 as as IN cord-023095-4dannjjm 2390 19 24 24 CD cord-023095-4dannjjm 2390 20 and and CC cord-023095-4dannjjm 2390 21 48 48 CD cord-023095-4dannjjm 2390 22 h h NN cord-023095-4dannjjm 2390 23 after after IN cord-023095-4dannjjm 2390 24 EUS EUS NNP cord-023095-4dannjjm 2390 25 FNA FNA NNP cord-023095-4dannjjm 2390 26 . . . cord-023095-4dannjjm 2391 1 The the DT cord-023095-4dannjjm 2391 2 EUS eus NN cord-023095-4dannjjm 2391 3 examination examination NN cord-023095-4dannjjm 2391 4 was be VBD cord-023095-4dannjjm 2391 5 complete complete JJ cord-023095-4dannjjm 2391 6 in in IN cord-023095-4dannjjm 2391 7 13/14 13/14 CD cord-023095-4dannjjm 2391 8 dogs dog NNS cord-023095-4dannjjm 2391 9 , , , cord-023095-4dannjjm 2391 10 the the DT cord-023095-4dannjjm 2391 11 pancreas pancreas NN cord-023095-4dannjjm 2391 12 could could MD cord-023095-4dannjjm 2391 13 not not RB cord-023095-4dannjjm 2391 14 be be VB cord-023095-4dannjjm 2391 15 visualized visualize VBN cord-023095-4dannjjm 2391 16 in in IN cord-023095-4dannjjm 2391 17 1 1 CD cord-023095-4dannjjm 2391 18 dog dog NN cord-023095-4dannjjm 2391 19 . . . cord-023095-4dannjjm 2392 1 The the DT cord-023095-4dannjjm 2392 2 pancreas pancreas NN cord-023095-4dannjjm 2392 3 was be VBD cord-023095-4dannjjm 2392 4 hypo-(4/13 hypo-(4/13 NN cord-023095-4dannjjm 2392 5 ) ) -RRB- cord-023095-4dannjjm 2392 6 to to IN cord-023095-4dannjjm 2392 7 isoechoic isoechoic NNP cord-023095-4dannjjm 2392 8 ( ( -LRB- cord-023095-4dannjjm 2392 9 9/13 9/13 CD cord-023095-4dannjjm 2392 10 ) ) -RRB- cord-023095-4dannjjm 2392 11 to to IN cord-023095-4dannjjm 2392 12 the the DT cord-023095-4dannjjm 2392 13 surrounding surround VBG cord-023095-4dannjjm 2392 14 mesenterium mesenterium NN cord-023095-4dannjjm 2392 15 in in IN cord-023095-4dannjjm 2392 16 all all DT cord-023095-4dannjjm 2392 17 cases case NNS cord-023095-4dannjjm 2392 18 . . . cord-023095-4dannjjm 2393 1 In in IN cord-023095-4dannjjm 2393 2 3/13 3/13 CD cord-023095-4dannjjm 2393 3 dogs dog NNS cord-023095-4dannjjm 2393 4 parts part NNS cord-023095-4dannjjm 2393 5 of of IN cord-023095-4dannjjm 2393 6 the the DT cord-023095-4dannjjm 2393 7 pancreas pancreas NN cord-023095-4dannjjm 2393 8 presented present VBD cord-023095-4dannjjm 2393 9 hyperechoic hyperechoic NNP cord-023095-4dannjjm 2393 10 . . . cord-023095-4dannjjm 2394 1 The the DT cord-023095-4dannjjm 2394 2 mean mean NN cord-023095-4dannjjm 2394 3 measured measure VBN cord-023095-4dannjjm 2394 4 thickness thickness NN cord-023095-4dannjjm 2394 5 was be VBD cord-023095-4dannjjm 2394 6 0.88 0.88 CD cord-023095-4dannjjm 2394 7 cm cm NNS cord-023095-4dannjjm 2394 8 . . . cord-023095-4dannjjm 2395 1 The the DT cord-023095-4dannjjm 2395 2 pancreas pancreas NN cord-023095-4dannjjm 2395 3 was be VBD cord-023095-4dannjjm 2395 4 aspirated aspirate VBN cord-023095-4dannjjm 2395 5 in in IN cord-023095-4dannjjm 2395 6 12 12 CD cord-023095-4dannjjm 2395 7 dogs dog NNS cord-023095-4dannjjm 2395 8 using use VBG cord-023095-4dannjjm 2395 9 a a DT cord-023095-4dannjjm 2395 10 transgastric transgastric JJ cord-023095-4dannjjm 2395 11 approach approach NN cord-023095-4dannjjm 2395 12 ( ( -LRB- cord-023095-4dannjjm 2395 13 3 3 CD cord-023095-4dannjjm 2395 14 ) ) -RRB- cord-023095-4dannjjm 2395 15 or or CC cord-023095-4dannjjm 2395 16 transduodenal transduodenal JJ cord-023095-4dannjjm 2395 17 approach approach NN cord-023095-4dannjjm 2395 18 ( ( -LRB- cord-023095-4dannjjm 2395 19 9 9 CD cord-023095-4dannjjm 2395 20 ) ) -RRB- cord-023095-4dannjjm 2395 21 . . . cord-023095-4dannjjm 2396 1 Duodenal Duodenal NNP cord-023095-4dannjjm 2396 2 transmural transmural NNP cord-023095-4dannjjm 2396 3 puncture puncture NN cord-023095-4dannjjm 2396 4 was be VBD cord-023095-4dannjjm 2396 5 not not RB cord-023095-4dannjjm 2396 6 accomplished accomplish VBN cord-023095-4dannjjm 2396 7 in in IN cord-023095-4dannjjm 2396 8 1 1 CD cord-023095-4dannjjm 2396 9 dog dog NN cord-023095-4dannjjm 2396 10 where where WRB cord-023095-4dannjjm 2396 11 a a DT cord-023095-4dannjjm 2396 12 re re NN cord-023095-4dannjjm 2396 13 - - JJ cord-023095-4dannjjm 2396 14 sterilized sterilized JJ cord-023095-4dannjjm 2396 15 needle needle NN cord-023095-4dannjjm 2396 16 was be VBD cord-023095-4dannjjm 2396 17 used use VBN cord-023095-4dannjjm 2396 18 . . . cord-023095-4dannjjm 2397 1 A a DT cord-023095-4dannjjm 2397 2 minimal minimal JJ cord-023095-4dannjjm 2397 3 amount amount NN cord-023095-4dannjjm 2397 4 of of IN cord-023095-4dannjjm 2397 5 peripancreatic peripancreatic JJ cord-023095-4dannjjm 2397 6 fluid fluid NN cord-023095-4dannjjm 2397 7 was be VBD cord-023095-4dannjjm 2397 8 observed observe VBN cord-023095-4dannjjm 2397 9 in in IN cord-023095-4dannjjm 2397 10 1/12 1/12 CD cord-023095-4dannjjm 2397 11 dogs dog NNS cord-023095-4dannjjm 2397 12 after after IN cord-023095-4dannjjm 2397 13 EUS EUS NNP cord-023095-4dannjjm 2397 14 FNA FNA NNP cord-023095-4dannjjm 2397 15 . . . cord-023095-4dannjjm 2398 1 All all DT cord-023095-4dannjjm 2398 2 dogs dog NNS cord-023095-4dannjjm 2398 3 recovered recover VBD cord-023095-4dannjjm 2398 4 uneventfully uneventfully RB cord-023095-4dannjjm 2398 5 and and CC cord-023095-4dannjjm 2398 6 required require VBD cord-023095-4dannjjm 2398 7 no no DT cord-023095-4dannjjm 2398 8 further further JJ cord-023095-4dannjjm 2398 9 analgesia analgesia NN cord-023095-4dannjjm 2398 10 . . . cord-023095-4dannjjm 2399 1 All all DT cord-023095-4dannjjm 2399 2 laboratory laboratory NN cord-023095-4dannjjm 2399 3 results result NNS cord-023095-4dannjjm 2399 4 including include VBG cord-023095-4dannjjm 2399 5 the the DT cord-023095-4dannjjm 2399 6 spec spec NN cord-023095-4dannjjm 2399 7 cPL cPL NNPS cord-023095-4dannjjm 2399 8 s s POS cord-023095-4dannjjm 2399 9 measurements measurement NNS cord-023095-4dannjjm 2399 10 were be VBD cord-023095-4dannjjm 2399 11 within within IN cord-023095-4dannjjm 2399 12 reference reference NN cord-023095-4dannjjm 2399 13 ranges range VBZ cord-023095-4dannjjm 2399 14 on on IN cord-023095-4dannjjm 2399 15 all all DT cord-023095-4dannjjm 2399 16 three three CD cord-023095-4dannjjm 2399 17 time time NN cord-023095-4dannjjm 2399 18 points point NNS cord-023095-4dannjjm 2399 19 . . . cord-023095-4dannjjm 2400 1 Cytologically cytologically RB cord-023095-4dannjjm 2400 2 , , , cord-023095-4dannjjm 2400 3 conglomerates conglomerate NNS cord-023095-4dannjjm 2400 4 of of IN cord-023095-4dannjjm 2400 5 exocrine exocrine JJ cord-023095-4dannjjm 2400 6 pancreatic pancreatic NN cord-023095-4dannjjm 2400 7 cells cell NNS cord-023095-4dannjjm 2400 8 were be VBD cord-023095-4dannjjm 2400 9 seen see VBN cord-023095-4dannjjm 2400 10 in in IN cord-023095-4dannjjm 2400 11 8/12 8/12 CD cord-023095-4dannjjm 2400 12 cases case NNS cord-023095-4dannjjm 2400 13 , , , cord-023095-4dannjjm 2400 14 duodenal duodenal JJ cord-023095-4dannjjm 2400 15 villous villous NN cord-023095-4dannjjm 2400 16 epithelial epithelial JJ cord-023095-4dannjjm 2400 17 cells cell NNS cord-023095-4dannjjm 2400 18 were be VBD cord-023095-4dannjjm 2400 19 seen see VBN cord-023095-4dannjjm 2400 20 in in IN cord-023095-4dannjjm 2400 21 11/12 11/12 CD cord-023095-4dannjjm 2400 22 cases case NNS cord-023095-4dannjjm 2400 23 . . . cord-023095-4dannjjm 2401 1 In in IN cord-023095-4dannjjm 2401 2 1 1 CD cord-023095-4dannjjm 2401 3 dog dog NN cord-023095-4dannjjm 2401 4 the the DT cord-023095-4dannjjm 2401 5 aspirated aspirated JJ cord-023095-4dannjjm 2401 6 pancreatic pancreatic JJ cord-023095-4dannjjm 2401 7 material material NN cord-023095-4dannjjm 2401 8 was be VBD cord-023095-4dannjjm 2401 9 sufficient sufficient JJ cord-023095-4dannjjm 2401 10 for for IN cord-023095-4dannjjm 2401 11 a a DT cord-023095-4dannjjm 2401 12 histological histological JJ cord-023095-4dannjjm 2401 13 assessment assessment NN cord-023095-4dannjjm 2401 14 . . . cord-023095-4dannjjm 2402 1 The the DT cord-023095-4dannjjm 2402 2 8 8 CD cord-023095-4dannjjm 2402 3 aspirates aspirate NNS cord-023095-4dannjjm 2402 4 with with IN cord-023095-4dannjjm 2402 5 exocrine exocrine JJ cord-023095-4dannjjm 2402 6 pancreatic pancreatic NN cord-023095-4dannjjm 2402 7 cells cell NNS cord-023095-4dannjjm 2402 8 on on IN cord-023095-4dannjjm 2402 9 cytology cytology NN cord-023095-4dannjjm 2402 10 were be VBD cord-023095-4dannjjm 2402 11 obtained obtain VBN cord-023095-4dannjjm 2402 12 by by IN cord-023095-4dannjjm 2402 13 transgastric transgastric NNP cord-023095-4dannjjm 2402 14 ( ( -LRB- cord-023095-4dannjjm 2402 15 4 4 CD cord-023095-4dannjjm 2402 16 ) ) -RRB- cord-023095-4dannjjm 2402 17 and and CC cord-023095-4dannjjm 2402 18 transduodenal transduodenal NNP cord-023095-4dannjjm 2402 19 ( ( -LRB- cord-023095-4dannjjm 2402 20 4 4 CD cord-023095-4dannjjm 2402 21 ) ) -RRB- cord-023095-4dannjjm 2402 22 aspirations aspiration NNS cord-023095-4dannjjm 2402 23 . . . cord-023095-4dannjjm 2403 1 In in IN cord-023095-4dannjjm 2403 2 conclusion conclusion NN cord-023095-4dannjjm 2403 3 , , , cord-023095-4dannjjm 2403 4 ( ( -LRB- cord-023095-4dannjjm 2403 5 1 1 LS cord-023095-4dannjjm 2403 6 ) ) -RRB- cord-023095-4dannjjm 2403 7 EUS eus NN cord-023095-4dannjjm 2403 8 examination examination NN cord-023095-4dannjjm 2403 9 of of IN cord-023095-4dannjjm 2403 10 the the DT cord-023095-4dannjjm 2403 11 abdomen abdomen NN cord-023095-4dannjjm 2403 12 is be VBZ cord-023095-4dannjjm 2403 13 feasible feasible JJ cord-023095-4dannjjm 2403 14 in in IN cord-023095-4dannjjm 2403 15 medium medium JJ cord-023095-4dannjjm 2403 16 - - HYPH cord-023095-4dannjjm 2403 17 sized sized JJ cord-023095-4dannjjm 2403 18 dogs dog NNS cord-023095-4dannjjm 2403 19 , , , cord-023095-4dannjjm 2403 20 ( ( -LRB- cord-023095-4dannjjm 2403 21 2 2 LS cord-023095-4dannjjm 2403 22 ) ) -RRB- cord-023095-4dannjjm 2403 23 the the DT cord-023095-4dannjjm 2403 24 healthy healthy JJ cord-023095-4dannjjm 2403 25 canine canine JJ cord-023095-4dannjjm 2403 26 pancreas pancrea NNS cord-023095-4dannjjm 2403 27 can can MD cord-023095-4dannjjm 2403 28 be be VB cord-023095-4dannjjm 2403 29 difficult difficult JJ cord-023095-4dannjjm 2403 30 to to TO cord-023095-4dannjjm 2403 31 visualize visualize VB cord-023095-4dannjjm 2403 32 completely completely RB cord-023095-4dannjjm 2403 33 , , , cord-023095-4dannjjm 2403 34 and and CC cord-023095-4dannjjm 2403 35 ( ( -LRB- cord-023095-4dannjjm 2403 36 3 3 LS cord-023095-4dannjjm 2403 37 ) ) -RRB- cord-023095-4dannjjm 2403 38 EUS eus NN cord-023095-4dannjjm 2403 39 - - HYPH cord-023095-4dannjjm 2403 40 guided guide VBN cord-023095-4dannjjm 2403 41 pancreatic pancreatic NN cord-023095-4dannjjm 2403 42 FNA FNA NNP cord-023095-4dannjjm 2403 43 using use VBG cord-023095-4dannjjm 2403 44 a a DT cord-023095-4dannjjm 2403 45 19 19 CD cord-023095-4dannjjm 2403 46 G g NN cord-023095-4dannjjm 2403 47 needle needle NN cord-023095-4dannjjm 2403 48 is be VBZ cord-023095-4dannjjm 2403 49 a a DT cord-023095-4dannjjm 2403 50 safe safe JJ cord-023095-4dannjjm 2403 51 procedure procedure NN cord-023095-4dannjjm 2403 52 in in IN cord-023095-4dannjjm 2403 53 healthy healthy JJ cord-023095-4dannjjm 2403 54 dogs dog NNS cord-023095-4dannjjm 2403 55 . . . cord-023095-4dannjjm 2404 1 Studies study NNS cord-023095-4dannjjm 2404 2 evaluating evaluate VBG cord-023095-4dannjjm 2404 3 its -PRON- PRP$ cord-023095-4dannjjm 2404 4 use use NN cord-023095-4dannjjm 2404 5 in in IN cord-023095-4dannjjm 2404 6 dogs dog NNS cord-023095-4dannjjm 2404 7 with with IN cord-023095-4dannjjm 2404 8 pancreatic pancreatic JJ cord-023095-4dannjjm 2404 9 disease disease NN cord-023095-4dannjjm 2404 10 are be VBP cord-023095-4dannjjm 2404 11 warranted warrant VBN cord-023095-4dannjjm 2404 12 to to TO cord-023095-4dannjjm 2404 13 assess assess VB cord-023095-4dannjjm 2404 14 its -PRON- PRP$ cord-023095-4dannjjm 2404 15 clinical clinical JJ cord-023095-4dannjjm 2404 16 utility utility NN cord-023095-4dannjjm 2404 17 . . . cord-023095-4dannjjm 2405 1 Miniature Miniature NNP cord-023095-4dannjjm 2405 2 Schnauzers Schnauzers NNPS cord-023095-4dannjjm 2405 3 have have VBP cord-023095-4dannjjm 2405 4 a a DT cord-023095-4dannjjm 2405 5 high high JJ cord-023095-4dannjjm 2405 6 prevalence prevalence NN cord-023095-4dannjjm 2405 7 of of IN cord-023095-4dannjjm 2405 8 idiopathic idiopathic JJ cord-023095-4dannjjm 2405 9 hyperlipidemia hyperlipidemia NN cord-023095-4dannjjm 2405 10 , , , cord-023095-4dannjjm 2405 11 which which WDT cord-023095-4dannjjm 2405 12 is be VBZ cord-023095-4dannjjm 2405 13 characterized characterize VBN cord-023095-4dannjjm 2405 14 by by IN cord-023095-4dannjjm 2405 15 an an DT cord-023095-4dannjjm 2405 16 increased increase VBN cord-023095-4dannjjm 2405 17 serum serum NN cord-023095-4dannjjm 2405 18 triglyceride triglyceride NN cord-023095-4dannjjm 2405 19 ( ( -LRB- cord-023095-4dannjjm 2405 20 TG TG NNP cord-023095-4dannjjm 2405 21 ) ) -RRB- cord-023095-4dannjjm 2405 22 concentration concentration NN cord-023095-4dannjjm 2405 23 , , , cord-023095-4dannjjm 2405 24 with with IN cord-023095-4dannjjm 2405 25 or or CC cord-023095-4dannjjm 2405 26 without without IN cord-023095-4dannjjm 2405 27 an an DT cord-023095-4dannjjm 2405 28 increased increase VBN cord-023095-4dannjjm 2405 29 serum serum NN cord-023095-4dannjjm 2405 30 cholesterol cholesterol NN cord-023095-4dannjjm 2405 31 ( ( -LRB- cord-023095-4dannjjm 2405 32 CHOL CHOL NNP cord-023095-4dannjjm 2405 33 ) ) -RRB- cord-023095-4dannjjm 2405 34 concentration concentration NN cord-023095-4dannjjm 2405 35 . . . cord-023095-4dannjjm 2406 1 A a DT cord-023095-4dannjjm 2406 2 common common JJ cord-023095-4dannjjm 2406 3 initial initial JJ cord-023095-4dannjjm 2406 4 therapeutic therapeutic JJ cord-023095-4dannjjm 2406 5 approach approach NN cord-023095-4dannjjm 2406 6 for for IN cord-023095-4dannjjm 2406 7 the the DT cord-023095-4dannjjm 2406 8 management management NN cord-023095-4dannjjm 2406 9 of of IN cord-023095-4dannjjm 2406 10 hyperlipidemia hyperlipidemia NN cord-023095-4dannjjm 2406 11 is be VBZ cord-023095-4dannjjm 2406 12 the the DT cord-023095-4dannjjm 2406 13 use use NN cord-023095-4dannjjm 2406 14 of of IN cord-023095-4dannjjm 2406 15 a a DT cord-023095-4dannjjm 2406 16 low low JJ cord-023095-4dannjjm 2406 17 - - HYPH cord-023095-4dannjjm 2406 18 fat fat NN cord-023095-4dannjjm 2406 19 diet diet NN cord-023095-4dannjjm 2406 20 . . . cord-023095-4dannjjm 2407 1 Also also RB cord-023095-4dannjjm 2407 2 , , , cord-023095-4dannjjm 2407 3 it -PRON- PRP cord-023095-4dannjjm 2407 4 is be VBZ cord-023095-4dannjjm 2407 5 believed believe VBN cord-023095-4dannjjm 2407 6 that that IN cord-023095-4dannjjm 2407 7 low low JJ cord-023095-4dannjjm 2407 8 - - HYPH cord-023095-4dannjjm 2407 9 fat fat NN cord-023095-4dannjjm 2407 10 diets diet NNS cord-023095-4dannjjm 2407 11 may may MD cord-023095-4dannjjm 2407 12 be be VB cord-023095-4dannjjm 2407 13 beneficial beneficial JJ cord-023095-4dannjjm 2407 14 in in IN cord-023095-4dannjjm 2407 15 the the DT cord-023095-4dannjjm 2407 16 treatment treatment NN cord-023095-4dannjjm 2407 17 of of IN cord-023095-4dannjjm 2407 18 pancreatitis pancreatitis NN cord-023095-4dannjjm 2407 19 in in IN cord-023095-4dannjjm 2407 20 dogs dog NNS cord-023095-4dannjjm 2407 21 . . . cord-023095-4dannjjm 2408 1 However however RB cord-023095-4dannjjm 2408 2 , , , cord-023095-4dannjjm 2408 3 the the DT cord-023095-4dannjjm 2408 4 efficacy efficacy NN cord-023095-4dannjjm 2408 5 of of IN cord-023095-4dannjjm 2408 6 this this DT cord-023095-4dannjjm 2408 7 approach approach NN cord-023095-4dannjjm 2408 8 has have VBZ cord-023095-4dannjjm 2408 9 not not RB cord-023095-4dannjjm 2408 10 been be VBN cord-023095-4dannjjm 2408 11 evaluated evaluate VBN cord-023095-4dannjjm 2408 12 for for IN cord-023095-4dannjjm 2408 13 either either DT cord-023095-4dannjjm 2408 14 condition condition NN cord-023095-4dannjjm 2408 15 . . . cord-023095-4dannjjm 2409 1 The the DT cord-023095-4dannjjm 2409 2 aim aim NN cord-023095-4dannjjm 2409 3 of of IN cord-023095-4dannjjm 2409 4 the the DT cord-023095-4dannjjm 2409 5 present present JJ cord-023095-4dannjjm 2409 6 study study NN cord-023095-4dannjjm 2409 7 was be VBD cord-023095-4dannjjm 2409 8 to to TO cord-023095-4dannjjm 2409 9 evaluate evaluate VB cord-023095-4dannjjm 2409 10 the the DT cord-023095-4dannjjm 2409 11 effect effect NN cord-023095-4dannjjm 2409 12 of of IN cord-023095-4dannjjm 2409 13 a a DT cord-023095-4dannjjm 2409 14 commercially commercially RB cord-023095-4dannjjm 2409 15 available available JJ cord-023095-4dannjjm 2409 16 low low JJ cord-023095-4dannjjm 2409 17 - - HYPH cord-023095-4dannjjm 2409 18 fat fat NN cord-023095-4dannjjm 2409 19 diet diet NN cord-023095-4dannjjm 2409 20 on on IN cord-023095-4dannjjm 2409 21 serum serum NN cord-023095-4dannjjm 2409 22 concentrations concentration NNS cord-023095-4dannjjm 2409 23 of of IN cord-023095-4dannjjm 2409 24 TG TG NNP cord-023095-4dannjjm 2409 25 , , , cord-023095-4dannjjm 2409 26 CHOL CHOL NNP cord-023095-4dannjjm 2409 27 , , , cord-023095-4dannjjm 2409 28 and and CC cord-023095-4dannjjm 2409 29 canine canine JJ cord-023095-4dannjjm 2409 30 pancreatic pancreatic JJ cord-023095-4dannjjm 2409 31 lipase lipase NN cord-023095-4dannjjm 2409 32 immunoreactivity immunoreactivity NN cord-023095-4dannjjm 2409 33 ( ( -LRB- cord-023095-4dannjjm 2409 34 cPLI cpli NN cord-023095-4dannjjm 2409 35 ; ; , cord-023095-4dannjjm 2409 36 measured measure VBN cord-023095-4dannjjm 2409 37 as as IN cord-023095-4dannjjm 2409 38 Spec Spec NNP cord-023095-4dannjjm 2409 39 cPL cPL NNS cord-023095-4dannjjm 2409 40 s s NNP cord-023095-4dannjjm 2409 41 ) ) -RRB- cord-023095-4dannjjm 2409 42 in in IN cord-023095-4dannjjm 2409 43 apparently apparently RB cord-023095-4dannjjm 2409 44 healthy healthy JJ cord-023095-4dannjjm 2409 45 Miniature Miniature NNP cord-023095-4dannjjm 2409 46 Schnauzers Schnauzers NNPS cord-023095-4dannjjm 2409 47 with with IN cord-023095-4dannjjm 2409 48 hypertriglyceridemia hypertriglyceridemia NN cord-023095-4dannjjm 2409 49 . . . cord-023095-4dannjjm 2410 1 Blood blood NN cord-023095-4dannjjm 2410 2 samples sample NNS cord-023095-4dannjjm 2410 3 were be VBD cord-023095-4dannjjm 2410 4 collected collect VBN cord-023095-4dannjjm 2410 5 from from IN cord-023095-4dannjjm 2410 6 15 15 CD cord-023095-4dannjjm 2410 7 apparently apparently RB cord-023095-4dannjjm 2410 8 healthy healthy JJ cord-023095-4dannjjm 2410 9 Miniature Miniature NNP cord-023095-4dannjjm 2410 10 Schnauzers Schnauzers NNPS cord-023095-4dannjjm 2410 11 with with IN cord-023095-4dannjjm 2410 12 hypertriglyceridemia hypertriglyceridemia NN cord-023095-4dannjjm 2410 13 ( ( -LRB- cord-023095-4dannjjm 2410 14 serum serum NN cord-023095-4dannjjm 2410 15 triglyceride triglyceride NN cord-023095-4dannjjm 2410 16 concentrations concentration NNS cord-023095-4dannjjm 2410 17 4 4 CD cord-023095-4dannjjm 2410 18 108 108 CD cord-023095-4dannjjm 2410 19 mg mg NN cord-023095-4dannjjm 2410 20 / / SYM cord-023095-4dannjjm 2410 21 dL dl NN cord-023095-4dannjjm 2410 22 ) ) -RRB- cord-023095-4dannjjm 2410 23 . . . cord-023095-4dannjjm 2411 1 Common common JJ cord-023095-4dannjjm 2411 2 causes cause NNS cord-023095-4dannjjm 2411 3 of of IN cord-023095-4dannjjm 2411 4 secondary secondary JJ cord-023095-4dannjjm 2411 5 hyperlipidemia hyperlipidemia NN cord-023095-4dannjjm 2411 6 were be VBD cord-023095-4dannjjm 2411 7 excluded exclude VBN cord-023095-4dannjjm 2411 8 based base VBN cord-023095-4dannjjm 2411 9 on on IN cord-023095-4dannjjm 2411 10 historical historical JJ cord-023095-4dannjjm 2411 11 information information NN cord-023095-4dannjjm 2411 12 , , , cord-023095-4dannjjm 2411 13 physical physical JJ cord-023095-4dannjjm 2411 14 examination examination NN cord-023095-4dannjjm 2411 15 findings finding NNS cord-023095-4dannjjm 2411 16 , , , cord-023095-4dannjjm 2411 17 and and CC cord-023095-4dannjjm 2411 18 the the DT cord-023095-4dannjjm 2411 19 measurement measurement NN cord-023095-4dannjjm 2411 20 of of IN cord-023095-4dannjjm 2411 21 serum serum NN cord-023095-4dannjjm 2411 22 glucose glucose NN cord-023095-4dannjjm 2411 23 , , , cord-023095-4dannjjm 2411 24 total total JJ cord-023095-4dannjjm 2411 25 T4 T4 NNP cord-023095-4dannjjm 2411 26 , , , cord-023095-4dannjjm 2411 27 and and CC cord-023095-4dannjjm 2411 28 free free JJ cord-023095-4dannjjm 2411 29 T4 T4 NNP cord-023095-4dannjjm 2411 30 ( ( -LRB- cord-023095-4dannjjm 2411 31 by by IN cord-023095-4dannjjm 2411 32 ED ED NNP cord-023095-4dannjjm 2411 33 ) ) -RRB- cord-023095-4dannjjm 2411 34 concentrations concentration NNS cord-023095-4dannjjm 2411 35 . . . cord-023095-4dannjjm 2412 1 The the DT cord-023095-4dannjjm 2412 2 owners owner NNS cord-023095-4dannjjm 2412 3 of of IN cord-023095-4dannjjm 2412 4 the the DT cord-023095-4dannjjm 2412 5 dogs dog NNS cord-023095-4dannjjm 2412 6 were be VBD cord-023095-4dannjjm 2412 7 asked ask VBN cord-023095-4dannjjm 2412 8 to to TO cord-023095-4dannjjm 2412 9 switch switch VB cord-023095-4dannjjm 2412 10 their -PRON- PRP$ cord-023095-4dannjjm 2412 11 dog dog NN cord-023095-4dannjjm 2412 12 to to IN cord-023095-4dannjjm 2412 13 the the DT cord-023095-4dannjjm 2412 14 study study NN cord-023095-4dannjjm 2412 15 diet diet NN cord-023095-4dannjjm 2412 16 ( ( -LRB- cord-023095-4dannjjm 2412 17 Royal Royal NNP cord-023095-4dannjjm 2412 18 Canin Canin NNP cord-023095-4dannjjm 2412 19 Gastrointestinal Gastrointestinal NNP cord-023095-4dannjjm 2412 20 Low Low NNP cord-023095-4dannjjm 2412 21 Fat Fat NNP cord-023095-4dannjjm 2412 22 s s NNPS cord-023095-4dannjjm 2412 23 ; ; : cord-023095-4dannjjm 2412 24 fat fat JJ cord-023095-4dannjjm 2412 25 content content NN cord-023095-4dannjjm 2412 26 : : : cord-023095-4dannjjm 2412 27 18.6 18.6 CD cord-023095-4dannjjm 2412 28 g/1,000 g/1,000 . cord-023095-4dannjjm 2412 29 Kcal Kcal NNP cord-023095-4dannjjm 2412 30 ) ) -RRB- cord-023095-4dannjjm 2412 31 and and CC cord-023095-4dannjjm 2412 32 have have VBP cord-023095-4dannjjm 2412 33 a a DT cord-023095-4dannjjm 2412 34 second second JJ cord-023095-4dannjjm 2412 35 blood blood NN cord-023095-4dannjjm 2412 36 sample sample NN cord-023095-4dannjjm 2412 37 collected collect VBD cord-023095-4dannjjm 2412 38 8 8 CD cord-023095-4dannjjm 2412 39 weeks week NNS cord-023095-4dannjjm 2412 40 after after IN cord-023095-4dannjjm 2412 41 their -PRON- PRP$ cord-023095-4dannjjm 2412 42 dog dog NN cord-023095-4dannjjm 2412 43 had have VBD cord-023095-4dannjjm 2412 44 been be VBN cord-023095-4dannjjm 2412 45 on on IN cord-023095-4dannjjm 2412 46 the the DT cord-023095-4dannjjm 2412 47 new new JJ cord-023095-4dannjjm 2412 48 diet diet NN cord-023095-4dannjjm 2412 49 . . . cord-023095-4dannjjm 2413 1 All all DT cord-023095-4dannjjm 2413 2 blood blood NN cord-023095-4dannjjm 2413 3 samples sample NNS cord-023095-4dannjjm 2413 4 were be VBD cord-023095-4dannjjm 2413 5 collected collect VBN cord-023095-4dannjjm 2413 6 after after IN cord-023095-4dannjjm 2413 7 food food NN cord-023095-4dannjjm 2413 8 had have VBD cord-023095-4dannjjm 2413 9 been be VBN cord-023095-4dannjjm 2413 10 withheld withhold VBN cord-023095-4dannjjm 2413 11 for for IN cord-023095-4dannjjm 2413 12 15 15 CD cord-023095-4dannjjm 2413 13 hours hour NNS cord-023095-4dannjjm 2413 14 . . . cord-023095-4dannjjm 2414 1 Serum serum NN cord-023095-4dannjjm 2414 2 TG TG NNP cord-023095-4dannjjm 2414 3 , , , cord-023095-4dannjjm 2414 4 CHOL CHOL NNP cord-023095-4dannjjm 2414 5 , , , cord-023095-4dannjjm 2414 6 and and CC cord-023095-4dannjjm 2414 7 Spec Spec NNP cord-023095-4dannjjm 2414 8 cPL cPL NNS cord-023095-4dannjjm 2414 9 concentrations concentration NNS cord-023095-4dannjjm 2414 10 were be VBD cord-023095-4dannjjm 2414 11 measured measure VBN cord-023095-4dannjjm 2414 12 both both CC cord-023095-4dannjjm 2414 13 before before IN cord-023095-4dannjjm 2414 14 and and CC cord-023095-4dannjjm 2414 15 after after IN cord-023095-4dannjjm 2414 16 the the DT cord-023095-4dannjjm 2414 17 diet diet NN cord-023095-4dannjjm 2414 18 change change NN cord-023095-4dannjjm 2414 19 . . . cord-023095-4dannjjm 2415 1 Results result NNS cord-023095-4dannjjm 2415 2 were be VBD cord-023095-4dannjjm 2415 3 compared compare VBN cord-023095-4dannjjm 2415 4 between between IN cord-023095-4dannjjm 2415 5 the the DT cord-023095-4dannjjm 2415 6 two two CD cord-023095-4dannjjm 2415 7 time time NN cord-023095-4dannjjm 2415 8 - - HYPH cord-023095-4dannjjm 2415 9 points point NNS cord-023095-4dannjjm 2415 10 using use VBG cord-023095-4dannjjm 2415 11 the the DT cord-023095-4dannjjm 2415 12 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 2415 13 signed sign VBN cord-023095-4dannjjm 2415 14 rank rank NN cord-023095-4dannjjm 2415 15 and and CC cord-023095-4dannjjm 2415 16 Fisher Fisher NNP cord-023095-4dannjjm 2415 17 's 's POS cord-023095-4dannjjm 2415 18 exact exact JJ cord-023095-4dannjjm 2415 19 tests test NNS cord-023095-4dannjjm 2415 20 . . . cord-023095-4dannjjm 2416 1 Serum serum NN cord-023095-4dannjjm 2416 2 TG TG NNP cord-023095-4dannjjm 2416 3 concentrations concentration NNS cord-023095-4dannjjm 2416 4 were be VBD cord-023095-4dannjjm 2416 5 significantly significantly RB cord-023095-4dannjjm 2416 6 higher high JJR cord-023095-4dannjjm 2416 7 before before IN cord-023095-4dannjjm 2416 8 ( ( -LRB- cord-023095-4dannjjm 2416 9 median median NN cord-023095-4dannjjm 2416 10 : : : cord-023095-4dannjjm 2416 11 432 432 CD cord-023095-4dannjjm 2416 12 mg mg NNP cord-023095-4dannjjm 2416 13 / / SYM cord-023095-4dannjjm 2416 14 dL dl NN cord-023095-4dannjjm 2416 15 ) ) -RRB- cord-023095-4dannjjm 2416 16 than than IN cord-023095-4dannjjm 2416 17 after after IN cord-023095-4dannjjm 2416 18 the the DT cord-023095-4dannjjm 2416 19 diet diet NN cord-023095-4dannjjm 2416 20 change change NN cord-023095-4dannjjm 2416 21 ( ( -LRB- cord-023095-4dannjjm 2416 22 median median NN cord-023095-4dannjjm 2416 23 : : : cord-023095-4dannjjm 2416 24 178 178 CD cord-023095-4dannjjm 2416 25 mg mg NNP cord-023095-4dannjjm 2416 26 / / SYM cord-023095-4dannjjm 2416 27 dL dl NN cord-023095-4dannjjm 2416 28 ; ; : cord-023095-4dannjjm 2416 29 p p NN cord-023095-4dannjjm 2416 30 5 5 CD cord-023095-4dannjjm 2416 31 0.003 0.003 CD cord-023095-4dannjjm 2416 32 ) ) -RRB- cord-023095-4dannjjm 2416 33 . . . cord-023095-4dannjjm 2417 1 The the DT cord-023095-4dannjjm 2417 2 proportion proportion NN cord-023095-4dannjjm 2417 3 of of IN cord-023095-4dannjjm 2417 4 dogs dog NNS cord-023095-4dannjjm 2417 5 with with IN cord-023095-4dannjjm 2417 6 hypertriglyceridemia hypertriglyceridemia NN cord-023095-4dannjjm 2417 7 was be VBD cord-023095-4dannjjm 2417 8 significantly significantly RB cord-023095-4dannjjm 2417 9 higher high JJR cord-023095-4dannjjm 2417 10 before before IN cord-023095-4dannjjm 2417 11 ( ( -LRB- cord-023095-4dannjjm 2417 12 15/15 15/15 CD cord-023095-4dannjjm 2417 13 ) ) -RRB- cord-023095-4dannjjm 2417 14 than than IN cord-023095-4dannjjm 2417 15 after after IN cord-023095-4dannjjm 2417 16 the the DT cord-023095-4dannjjm 2417 17 diet diet NN cord-023095-4dannjjm 2417 18 change change NN cord-023095-4dannjjm 2417 19 ( ( -LRB- cord-023095-4dannjjm 2417 20 10/15 10/15 CD cord-023095-4dannjjm 2417 21 ; ; : cord-023095-4dannjjm 2417 22 p p NN cord-023095-4dannjjm 2417 23 5 5 CD cord-023095-4dannjjm 2417 24 0.042 0.042 CD cord-023095-4dannjjm 2417 25 ) ) -RRB- cord-023095-4dannjjm 2417 26 . . . cord-023095-4dannjjm 2418 1 Also also RB cord-023095-4dannjjm 2418 2 , , , cord-023095-4dannjjm 2418 3 the the DT cord-023095-4dannjjm 2418 4 proportion proportion NN cord-023095-4dannjjm 2418 5 of of IN cord-023095-4dannjjm 2418 6 dogs dog NNS cord-023095-4dannjjm 2418 7 with with IN cord-023095-4dannjjm 2418 8 serum serum NN cord-023095-4dannjjm 2418 9 TG TG NNP cord-023095-4dannjjm 2418 10 4 4 CD cord-023095-4dannjjm 2418 11 500 500 CD cord-023095-4dannjjm 2419 1 mg mg NNP cord-023095-4dannjjm 2419 2 / / SYM cord-023095-4dannjjm 2419 3 dL dL NNP cord-023095-4dannjjm 2419 4 was be VBD cord-023095-4dannjjm 2419 5 significantly significantly RB cord-023095-4dannjjm 2419 6 higher high JJR cord-023095-4dannjjm 2419 7 before before IN cord-023095-4dannjjm 2419 8 ( ( -LRB- cord-023095-4dannjjm 2419 9 6/15 6/15 CD cord-023095-4dannjjm 2419 10 ) ) -RRB- cord-023095-4dannjjm 2419 11 than than IN cord-023095-4dannjjm 2419 12 after after IN cord-023095-4dannjjm 2419 13 the the DT cord-023095-4dannjjm 2419 14 diet diet NN cord-023095-4dannjjm 2419 15 change change NN cord-023095-4dannjjm 2419 16 ( ( -LRB- cord-023095-4dannjjm 2419 17 0/15 0/15 CD cord-023095-4dannjjm 2419 18 ; ; : cord-023095-4dannjjm 2419 19 p p NN cord-023095-4dannjjm 2419 20 5 5 CD cord-023095-4dannjjm 2419 21 0.016 0.016 CD cord-023095-4dannjjm 2419 22 ) ) -RRB- cord-023095-4dannjjm 2419 23 . . . cord-023095-4dannjjm 2420 1 Serum serum NN cord-023095-4dannjjm 2420 2 CHOL CHOL NNP cord-023095-4dannjjm 2420 3 concentrations concentration NNS cord-023095-4dannjjm 2420 4 were be VBD cord-023095-4dannjjm 2420 5 significantly significantly RB cord-023095-4dannjjm 2420 6 higher high JJR cord-023095-4dannjjm 2420 7 before before IN cord-023095-4dannjjm 2420 8 ( ( -LRB- cord-023095-4dannjjm 2420 9 median median NN cord-023095-4dannjjm 2420 10 : : : cord-023095-4dannjjm 2420 11 296 296 CD cord-023095-4dannjjm 2420 12 mg mg NNP cord-023095-4dannjjm 2420 13 / / SYM cord-023095-4dannjjm 2420 14 dL dl NN cord-023095-4dannjjm 2420 15 ) ) -RRB- cord-023095-4dannjjm 2420 16 than than IN cord-023095-4dannjjm 2420 17 after after IN cord-023095-4dannjjm 2420 18 the the DT cord-023095-4dannjjm 2420 19 diet diet NN cord-023095-4dannjjm 2420 20 change change NN cord-023095-4dannjjm 2420 21 ( ( -LRB- cord-023095-4dannjjm 2420 22 median median NN cord-023095-4dannjjm 2420 23 : : : cord-023095-4dannjjm 2420 24 258 258 CD cord-023095-4dannjjm 2420 25 mg mg NNP cord-023095-4dannjjm 2420 26 / / SYM cord-023095-4dannjjm 2420 27 dL dl NN cord-023095-4dannjjm 2420 28 ; ; : cord-023095-4dannjjm 2420 29 p p NN cord-023095-4dannjjm 2420 30 5 5 CD cord-023095-4dannjjm 2420 31 0.004 0.004 CD cord-023095-4dannjjm 2420 32 ) ) -RRB- cord-023095-4dannjjm 2420 33 . . . cord-023095-4dannjjm 2421 1 The the DT cord-023095-4dannjjm 2421 2 proportion proportion NN cord-023095-4dannjjm 2421 3 of of IN cord-023095-4dannjjm 2421 4 dogs dog NNS cord-023095-4dannjjm 2421 5 with with IN cord-023095-4dannjjm 2421 6 hypercholesterolemia hypercholesterolemia NN cord-023095-4dannjjm 2421 7 was be VBD cord-023095-4dannjjm 2421 8 significantly significantly RB cord-023095-4dannjjm 2421 9 higher high JJR cord-023095-4dannjjm 2421 10 before before IN cord-023095-4dannjjm 2421 11 ( ( -LRB- cord-023095-4dannjjm 2421 12 8/15 8/15 CD cord-023095-4dannjjm 2421 13 ) ) -RRB- cord-023095-4dannjjm 2421 14 than than IN cord-023095-4dannjjm 2421 15 after after IN cord-023095-4dannjjm 2421 16 the the DT cord-023095-4dannjjm 2421 17 diet diet NN cord-023095-4dannjjm 2421 18 change change NN cord-023095-4dannjjm 2421 19 ( ( -LRB- cord-023095-4dannjjm 2421 20 0/15 0/15 CD cord-023095-4dannjjm 2421 21 ; ; : cord-023095-4dannjjm 2421 22 p p NN cord-023095-4dannjjm 2421 23 5 5 CD cord-023095-4dannjjm 2421 24 0.006 0.006 CD cord-023095-4dannjjm 2421 25 ) ) -RRB- cord-023095-4dannjjm 2421 26 . . . cord-023095-4dannjjm 2422 1 Finally finally RB cord-023095-4dannjjm 2422 2 , , , cord-023095-4dannjjm 2422 3 the the DT cord-023095-4dannjjm 2422 4 difference difference NN cord-023095-4dannjjm 2422 5 in in IN cord-023095-4dannjjm 2422 6 serum serum NN cord-023095-4dannjjm 2422 7 Spec spec NN cord-023095-4dannjjm 2422 8 cPL cPL NNS cord-023095-4dannjjm 2422 9 concentrations concentration NNS cord-023095-4dannjjm 2422 10 before before IN cord-023095-4dannjjm 2422 11 ( ( -LRB- cord-023095-4dannjjm 2422 12 median median NN cord-023095-4dannjjm 2422 13 : : : cord-023095-4dannjjm 2422 14 88 88 CD cord-023095-4dannjjm 2422 15 mg mg NNP cord-023095-4dannjjm 2422 16 / / SYM cord-023095-4dannjjm 2422 17 L L NNP cord-023095-4dannjjm 2422 18 ) ) -RRB- cord-023095-4dannjjm 2422 19 and and CC cord-023095-4dannjjm 2422 20 after after IN cord-023095-4dannjjm 2422 21 the the DT cord-023095-4dannjjm 2422 22 diet diet NN cord-023095-4dannjjm 2422 23 change change NN cord-023095-4dannjjm 2422 24 ( ( -LRB- cord-023095-4dannjjm 2422 25 median median NN cord-023095-4dannjjm 2422 26 : : : cord-023095-4dannjjm 2422 27 56 56 CD cord-023095-4dannjjm 2422 28 mg mg NNP cord-023095-4dannjjm 2422 29 / / SYM cord-023095-4dannjjm 2422 30 L L NNP cord-023095-4dannjjm 2422 31 ) ) -RRB- cord-023095-4dannjjm 2422 32 approached approach VBD cord-023095-4dannjjm 2422 33 but but CC cord-023095-4dannjjm 2422 34 did do VBD cord-023095-4dannjjm 2422 35 not not RB cord-023095-4dannjjm 2422 36 reach reach VB cord-023095-4dannjjm 2422 37 significance significance NN cord-023095-4dannjjm 2422 38 ( ( -LRB- cord-023095-4dannjjm 2422 39 p p NN cord-023095-4dannjjm 2422 40 5 5 CD cord-023095-4dannjjm 2422 41 0.052 0.052 CD cord-023095-4dannjjm 2422 42 ) ) -RRB- cord-023095-4dannjjm 2422 43 . . . cord-023095-4dannjjm 2423 1 Also also RB cord-023095-4dannjjm 2423 2 , , , cord-023095-4dannjjm 2423 3 the the DT cord-023095-4dannjjm 2423 4 proportion proportion NN cord-023095-4dannjjm 2423 5 of of IN cord-023095-4dannjjm 2423 6 dogs dog NNS cord-023095-4dannjjm 2423 7 with with IN cord-023095-4dannjjm 2423 8 high high JJ cord-023095-4dannjjm 2423 9 serum serum NN cord-023095-4dannjjm 2423 10 Spec spec NN cord-023095-4dannjjm 2423 11 cPL cPL NNS cord-023095-4dannjjm 2423 12 concentrations concentration NNS cord-023095-4dannjjm 2423 13 before before IN cord-023095-4dannjjm 2423 14 ( ( -LRB- cord-023095-4dannjjm 2423 15 4/15 4/15 CD cord-023095-4dannjjm 2423 16 ) ) -RRB- cord-023095-4dannjjm 2423 17 and and CC cord-023095-4dannjjm 2423 18 after after IN cord-023095-4dannjjm 2423 19 the the DT cord-023095-4dannjjm 2423 20 diet diet NN cord-023095-4dannjjm 2423 21 change change NN cord-023095-4dannjjm 2423 22 ( ( -LRB- cord-023095-4dannjjm 2423 23 0/15 0/15 CD cord-023095-4dannjjm 2423 24 ) ) -RRB- cord-023095-4dannjjm 2423 25 was be VBD cord-023095-4dannjjm 2423 26 different different JJ cord-023095-4dannjjm 2423 27 , , , cord-023095-4dannjjm 2423 28 but but CC cord-023095-4dannjjm 2423 29 this this DT cord-023095-4dannjjm 2423 30 difference difference NN cord-023095-4dannjjm 2423 31 was be VBD cord-023095-4dannjjm 2423 32 not not RB cord-023095-4dannjjm 2423 33 significant significant JJ cord-023095-4dannjjm 2423 34 ( ( -LRB- cord-023095-4dannjjm 2423 35 p p NN cord-023095-4dannjjm 2423 36 5 5 CD cord-023095-4dannjjm 2423 37 0.099 0.099 CD cord-023095-4dannjjm 2423 38 ) ) -RRB- cord-023095-4dannjjm 2423 39 . . . cord-023095-4dannjjm 2424 1 In in IN cord-023095-4dannjjm 2424 2 summary summary NN cord-023095-4dannjjm 2424 3 , , , cord-023095-4dannjjm 2424 4 a a DT cord-023095-4dannjjm 2424 5 commercially commercially RB cord-023095-4dannjjm 2424 6 available available JJ cord-023095-4dannjjm 2424 7 low low JJ cord-023095-4dannjjm 2424 8 - - HYPH cord-023095-4dannjjm 2424 9 fat fat NN cord-023095-4dannjjm 2424 10 diet diet NN cord-023095-4dannjjm 2424 11 was be VBD cord-023095-4dannjjm 2424 12 effective effective JJ cord-023095-4dannjjm 2424 13 in in IN cord-023095-4dannjjm 2424 14 reducing reduce VBG cord-023095-4dannjjm 2424 15 serum serum NN cord-023095-4dannjjm 2424 16 TG TG NNP cord-023095-4dannjjm 2424 17 and and CC cord-023095-4dannjjm 2424 18 CHOL CHOL NNP cord-023095-4dannjjm 2424 19 concentrations concentration NNS cord-023095-4dannjjm 2424 20 in in IN cord-023095-4dannjjm 2424 21 Miniature Miniature NNP cord-023095-4dannjjm 2424 22 Schnauzers Schnauzers NNPS cord-023095-4dannjjm 2424 23 with with IN cord-023095-4dannjjm 2424 24 hypertriglyceridemia hypertriglyceridemia NN cord-023095-4dannjjm 2424 25 . . . cord-023095-4dannjjm 2425 1 Toll toll NN cord-023095-4dannjjm 2425 2 - - HYPH cord-023095-4dannjjm 2425 3 like like JJ cord-023095-4dannjjm 2425 4 receptor receptor NN cord-023095-4dannjjm 2425 5 5 5 CD cord-023095-4dannjjm 2426 1 ( ( -LRB- cord-023095-4dannjjm 2426 2 TLR5 TLR5 NNP cord-023095-4dannjjm 2426 3 ) ) -RRB- cord-023095-4dannjjm 2426 4 is be VBZ cord-023095-4dannjjm 2426 5 an an DT cord-023095-4dannjjm 2426 6 extracellular extracellular JJ cord-023095-4dannjjm 2426 7 pattern pattern NN cord-023095-4dannjjm 2426 8 recognition recognition NN cord-023095-4dannjjm 2426 9 receptor receptor NN cord-023095-4dannjjm 2426 10 which which WDT cord-023095-4dannjjm 2426 11 recognizes recognize VBZ cord-023095-4dannjjm 2426 12 flagellin flagellin JJ cord-023095-4dannjjm 2426 13 present present NN cord-023095-4dannjjm 2426 14 in in IN cord-023095-4dannjjm 2426 15 motile motile JJ cord-023095-4dannjjm 2426 16 bacteria bacteria NNS cord-023095-4dannjjm 2426 17 . . . cord-023095-4dannjjm 2427 1 We -PRON- PRP cord-023095-4dannjjm 2427 2 have have VBP cord-023095-4dannjjm 2427 3 previously previously RB cord-023095-4dannjjm 2427 4 demonstrated demonstrate VBN cord-023095-4dannjjm 2427 5 a a DT cord-023095-4dannjjm 2427 6 significant significant JJ cord-023095-4dannjjm 2427 7 association association NN cord-023095-4dannjjm 2427 8 between between IN cord-023095-4dannjjm 2427 9 three three CD cord-023095-4dannjjm 2427 10 non non JJ cord-023095-4dannjjm 2427 11 - - JJ cord-023095-4dannjjm 2427 12 synonymous synonymous JJ cord-023095-4dannjjm 2427 13 single single JJ cord-023095-4dannjjm 2427 14 nucleotide nucleotide JJ cord-023095-4dannjjm 2427 15 polymorphisms polymorphism NNS cord-023095-4dannjjm 2427 16 ( ( -LRB- cord-023095-4dannjjm 2427 17 SNPs SNPs NNP cord-023095-4dannjjm 2427 18 ) ) -RRB- cord-023095-4dannjjm 2427 19 in in IN cord-023095-4dannjjm 2427 20 the the DT cord-023095-4dannjjm 2427 21 TLR5 TLR5 NNP cord-023095-4dannjjm 2427 22 gene gene NN cord-023095-4dannjjm 2427 23 ( ( -LRB- cord-023095-4dannjjm 2427 24 G22A g22a NN cord-023095-4dannjjm 2427 25 , , , cord-023095-4dannjjm 2427 26 C100 C100 NNP cord-023095-4dannjjm 2427 27 T T NNP cord-023095-4dannjjm 2427 28 and and CC cord-023095-4dannjjm 2427 29 T1844C T1844C NNP cord-023095-4dannjjm 2427 30 ) ) -RRB- cord-023095-4dannjjm 2427 31 and and CC cord-023095-4dannjjm 2427 32 inflammatory inflammatory JJ cord-023095-4dannjjm 2427 33 bowel bowel NN cord-023095-4dannjjm 2427 34 disease disease NN cord-023095-4dannjjm 2427 35 ( ( -LRB- cord-023095-4dannjjm 2427 36 IBD IBD NNP cord-023095-4dannjjm 2427 37 ) ) -RRB- cord-023095-4dannjjm 2427 38 in in IN cord-023095-4dannjjm 2427 39 German german JJ cord-023095-4dannjjm 2427 40 shepherd shepherd NN cord-023095-4dannjjm 2427 41 dogs dog NNS cord-023095-4dannjjm 2427 42 ( ( -LRB- cord-023095-4dannjjm 2427 43 GSDs GSDs NNP cord-023095-4dannjjm 2427 44 ) ) -RRB- cord-023095-4dannjjm 2427 45 . . . cord-023095-4dannjjm 2428 1 Recently recently RB cord-023095-4dannjjm 2428 2 , , , cord-023095-4dannjjm 2428 3 we -PRON- PRP cord-023095-4dannjjm 2428 4 have have VBP cord-023095-4dannjjm 2428 5 confirmed confirm VBN cord-023095-4dannjjm 2428 6 that that IN cord-023095-4dannjjm 2428 7 two two CD cord-023095-4dannjjm 2428 8 of of IN cord-023095-4dannjjm 2428 9 these these DT cord-023095-4dannjjm 2428 10 TLR5 TLR5 NNP cord-023095-4dannjjm 2428 11 SNPs SNPs NNPS cord-023095-4dannjjm 2428 12 ( ( -LRB- cord-023095-4dannjjm 2428 13 C100 C100 NNP cord-023095-4dannjjm 2428 14 T T NNP cord-023095-4dannjjm 2428 15 and and CC cord-023095-4dannjjm 2428 16 T1844C T1844C NNP cord-023095-4dannjjm 2428 17 ) ) -RRB- cord-023095-4dannjjm 2428 18 are be VBP cord-023095-4dannjjm 2428 19 significantly significantly RB cord-023095-4dannjjm 2428 20 associated associate VBN cord-023095-4dannjjm 2428 21 with with IN cord-023095-4dannjjm 2428 22 IBD IBD NNP cord-023095-4dannjjm 2428 23 in in IN cord-023095-4dannjjm 2428 24 other other JJ cord-023095-4dannjjm 2428 25 canine canine JJ cord-023095-4dannjjm 2428 26 breeds breed NNS cord-023095-4dannjjm 2428 27 . . . cord-023095-4dannjjm 2429 1 To to TO cord-023095-4dannjjm 2429 2 further further RB cord-023095-4dannjjm 2429 3 substantiate substantiate VB cord-023095-4dannjjm 2429 4 the the DT cord-023095-4dannjjm 2429 5 role role NN cord-023095-4dannjjm 2429 6 of of IN cord-023095-4dannjjm 2429 7 TLR5 TLR5 NNP cord-023095-4dannjjm 2429 8 in in IN cord-023095-4dannjjm 2429 9 canine canine JJ cord-023095-4dannjjm 2429 10 IBD IBD NNP cord-023095-4dannjjm 2429 11 functional functional JJ cord-023095-4dannjjm 2429 12 analysis analysis NN cord-023095-4dannjjm 2429 13 of of IN cord-023095-4dannjjm 2429 14 these these DT cord-023095-4dannjjm 2429 15 polymorphisms polymorphism NNS cord-023095-4dannjjm 2429 16 would would MD cord-023095-4dannjjm 2429 17 be be VB cord-023095-4dannjjm 2429 18 needed need VBN cord-023095-4dannjjm 2429 19 . . . cord-023095-4dannjjm 2430 1 Therefore therefore RB cord-023095-4dannjjm 2430 2 the the DT cord-023095-4dannjjm 2430 3 aim aim NN cord-023095-4dannjjm 2430 4 of of IN cord-023095-4dannjjm 2430 5 this this DT cord-023095-4dannjjm 2430 6 study study NN cord-023095-4dannjjm 2430 7 was be VBD cord-023095-4dannjjm 2430 8 to to TO cord-023095-4dannjjm 2430 9 determine determine VB cord-023095-4dannjjm 2430 10 the the DT cord-023095-4dannjjm 2430 11 functional functional JJ cord-023095-4dannjjm 2430 12 significance significance NN cord-023095-4dannjjm 2430 13 of of IN cord-023095-4dannjjm 2430 14 the the DT cord-023095-4dannjjm 2430 15 TLR5 TLR5 NNP cord-023095-4dannjjm 2430 16 SNPs snp NNS cord-023095-4dannjjm 2430 17 by by IN cord-023095-4dannjjm 2430 18 transfecting transfecte VBG cord-023095-4dannjjm 2430 19 wild wild JJ cord-023095-4dannjjm 2430 20 - - HYPH cord-023095-4dannjjm 2430 21 type type NN cord-023095-4dannjjm 2430 22 and and CC cord-023095-4dannjjm 2430 23 mutant mutant JJ cord-023095-4dannjjm 2430 24 receptors receptor NNS cord-023095-4dannjjm 2430 25 in in IN cord-023095-4dannjjm 2430 26 to to IN cord-023095-4dannjjm 2430 27 human human JJ cord-023095-4dannjjm 2430 28 embryonic embryonic JJ cord-023095-4dannjjm 2430 29 kidney kidney NN cord-023095-4dannjjm 2430 30 cells cell NNS cord-023095-4dannjjm 2430 31 ( ( -LRB- cord-023095-4dannjjm 2430 32 HEK HEK NNP cord-023095-4dannjjm 2430 33 ) ) -RRB- cord-023095-4dannjjm 2430 34 and and CC cord-023095-4dannjjm 2430 35 carrying carry VBG cord-023095-4dannjjm 2430 36 out out RP cord-023095-4dannjjm 2430 37 nuclear nuclear JJ cord-023095-4dannjjm 2430 38 factorkappa factorkappa NN cord-023095-4dannjjm 2430 39 B b NN cord-023095-4dannjjm 2430 40 ( ( -LRB- cord-023095-4dannjjm 2430 41 NF NF NNP cord-023095-4dannjjm 2430 42 - - HYPH cord-023095-4dannjjm 2430 43 kB kB NNP cord-023095-4dannjjm 2430 44 ) ) -RRB- cord-023095-4dannjjm 2430 45 luciferase luciferase NN cord-023095-4dannjjm 2430 46 assay assay NN cord-023095-4dannjjm 2430 47 and and CC cord-023095-4dannjjm 2430 48 IL-8 IL-8 NNP cord-023095-4dannjjm 2430 49 ELISA ELISA NNP cord-023095-4dannjjm 2430 50 . . . cord-023095-4dannjjm 2431 1 The the DT cord-023095-4dannjjm 2431 2 TLR5 TLR5 NNP cord-023095-4dannjjm 2431 3 gene gene NN cord-023095-4dannjjm 2431 4 containing contain VBG cord-023095-4dannjjm 2431 5 the the DT cord-023095-4dannjjm 2431 6 risk risk NN cord-023095-4dannjjm 2431 7 haplotype haplotype NN cord-023095-4dannjjm 2431 8 for for IN cord-023095-4dannjjm 2431 9 IBD IBD NNP cord-023095-4dannjjm 2431 10 ( ( -LRB- cord-023095-4dannjjm 2431 11 ACC ACC NNP cord-023095-4dannjjm 2431 12 ) ) -RRB- cord-023095-4dannjjm 2431 13 and and CC cord-023095-4dannjjm 2431 14 wild wild JJ cord-023095-4dannjjm 2431 15 - - HYPH cord-023095-4dannjjm 2431 16 type type NN cord-023095-4dannjjm 2431 17 haplotype haplotype NN cord-023095-4dannjjm 2431 18 ( ( -LRB- cord-023095-4dannjjm 2431 19 GTT GTT NNP cord-023095-4dannjjm 2431 20 ) ) -RRB- cord-023095-4dannjjm 2431 21 as as IN cord-023095-4dannjjm 2431 22 determined determine VBN cord-023095-4dannjjm 2431 23 by by IN cord-023095-4dannjjm 2431 24 the the DT cord-023095-4dannjjm 2431 25 case case NN cord-023095-4dannjjm 2431 26 - - HYPH cord-023095-4dannjjm 2431 27 control control NN cord-023095-4dannjjm 2431 28 analysis analysis NN cord-023095-4dannjjm 2431 29 in in IN cord-023095-4dannjjm 2431 30 GSDs gsds NN cord-023095-4dannjjm 2431 31 with with IN cord-023095-4dannjjm 2431 32 IBD IBD NNP cord-023095-4dannjjm 2431 33 were be VBD cord-023095-4dannjjm 2431 34 cloned clone VBN cord-023095-4dannjjm 2431 35 into into IN cord-023095-4dannjjm 2431 36 plasmids plasmid NNS cord-023095-4dannjjm 2431 37 expressing express VBG cord-023095-4dannjjm 2431 38 yellow yellow JJ cord-023095-4dannjjm 2431 39 - - HYPH cord-023095-4dannjjm 2431 40 fluorescent fluorescent NN cord-023095-4dannjjm 2431 41 protein protein NN cord-023095-4dannjjm 2431 42 ( ( -LRB- cord-023095-4dannjjm 2431 43 YFP YFP NNP cord-023095-4dannjjm 2431 44 ) ) -RRB- cord-023095-4dannjjm 2431 45 . . . cord-023095-4dannjjm 2432 1 These these DT cord-023095-4dannjjm 2432 2 were be VBD cord-023095-4dannjjm 2432 3 then then RB cord-023095-4dannjjm 2432 4 stably stably RB cord-023095-4dannjjm 2432 5 transfected transfecte VBN cord-023095-4dannjjm 2432 6 into into IN cord-023095-4dannjjm 2432 7 HEK HEK NNP cord-023095-4dannjjm 2432 8 cells cell NNS cord-023095-4dannjjm 2432 9 . . . cord-023095-4dannjjm 2433 1 NF NF NNP cord-023095-4dannjjm 2433 2 - - HYPH cord-023095-4dannjjm 2433 3 kB kb CD cord-023095-4dannjjm 2433 4 activity activity NN cord-023095-4dannjjm 2433 5 was be VBD cord-023095-4dannjjm 2433 6 measured measure VBN cord-023095-4dannjjm 2433 7 by by IN cord-023095-4dannjjm 2433 8 transiently transiently RB cord-023095-4dannjjm 2433 9 transfecting transfecte VBG cord-023095-4dannjjm 2433 10 the the DT cord-023095-4dannjjm 2433 11 cells cell NNS cord-023095-4dannjjm 2433 12 with with IN cord-023095-4dannjjm 2433 13 NF NF NNP cord-023095-4dannjjm 2433 14 - - HYPH cord-023095-4dannjjm 2433 15 kB kb CD cord-023095-4dannjjm 2433 16 firefly firefly NN cord-023095-4dannjjm 2433 17 and and CC cord-023095-4dannjjm 2433 18 HSV HSV NNP cord-023095-4dannjjm 2433 19 - - HYPH cord-023095-4dannjjm 2433 20 thymidine thymidine NN cord-023095-4dannjjm 2433 21 kinase kinase NN cord-023095-4dannjjm 2433 22 promoter promoter NN cord-023095-4dannjjm 2433 23 ( ( -LRB- cord-023095-4dannjjm 2433 24 pRL pRL NNP cord-023095-4dannjjm 2433 25 - - HYPH cord-023095-4dannjjm 2433 26 TK TK NNP cord-023095-4dannjjm 2433 27 ) ) -RRB- cord-023095-4dannjjm 2433 28 renilla renilla NNP cord-023095-4dannjjm 2433 29 plasmids plasmid NNS cord-023095-4dannjjm 2433 30 . . . cord-023095-4dannjjm 2434 1 The the DT cord-023095-4dannjjm 2434 2 cells cell NNS cord-023095-4dannjjm 2434 3 were be VBD cord-023095-4dannjjm 2434 4 then then RB cord-023095-4dannjjm 2434 5 stimulated stimulate VBN cord-023095-4dannjjm 2434 6 with with IN cord-023095-4dannjjm 2434 7 various various JJ cord-023095-4dannjjm 2434 8 ligands ligand NNS cord-023095-4dannjjm 2434 9 ( ( -LRB- cord-023095-4dannjjm 2434 10 0.1 0.1 CD cord-023095-4dannjjm 2434 11 mg mg NNP cord-023095-4dannjjm 2434 12 / / SYM cord-023095-4dannjjm 2434 13 ml ml NNP cord-023095-4dannjjm 2434 14 flagellin flagellin NNP cord-023095-4dannjjm 2434 15 , , , cord-023095-4dannjjm 2434 16 0.01 0.01 CD cord-023095-4dannjjm 2434 17 mg mg NNP cord-023095-4dannjjm 2434 18 / / SYM cord-023095-4dannjjm 2434 19 ml ml NNP cord-023095-4dannjjm 2434 20 flagellin flagellin NNP cord-023095-4dannjjm 2434 21 , , , cord-023095-4dannjjm 2434 22 1 1 CD cord-023095-4dannjjm 2434 23 mg mg NNP cord-023095-4dannjjm 2434 24 / / SYM cord-023095-4dannjjm 2434 25 ml ml NNP cord-023095-4dannjjm 2434 26 LPS LPS NNP cord-023095-4dannjjm 2434 27 , , , cord-023095-4dannjjm 2434 28 1 1 CD cord-023095-4dannjjm 2434 29 mg mg NNP cord-023095-4dannjjm 2434 30 / / SYM cord-023095-4dannjjm 2434 31 ml ml NNP cord-023095-4dannjjm 2434 32 PAM3CSK PAM3CSK NNP cord-023095-4dannjjm 2434 33 and and CC cord-023095-4dannjjm 2434 34 media medium NNS cord-023095-4dannjjm 2434 35 control control NN cord-023095-4dannjjm 2434 36 ) ) -RRB- cord-023095-4dannjjm 2434 37 . . . cord-023095-4dannjjm 2435 1 Firefly Firefly NNP cord-023095-4dannjjm 2435 2 and and CC cord-023095-4dannjjm 2435 3 renilla renilla NNP cord-023095-4dannjjm 2435 4 luciferase luciferase NN cord-023095-4dannjjm 2435 5 activities activity NNS cord-023095-4dannjjm 2435 6 were be VBD cord-023095-4dannjjm 2435 7 measured measure VBN cord-023095-4dannjjm 2435 8 using use VBG cord-023095-4dannjjm 2435 9 the the DT cord-023095-4dannjjm 2435 10 Dual Dual NNP cord-023095-4dannjjm 2435 11 - - HYPH cord-023095-4dannjjm 2435 12 Glo Glo NNP cord-023095-4dannjjm 2435 13 Luciferase Luciferase NNP cord-023095-4dannjjm 2435 14 Assay Assay NNP cord-023095-4dannjjm 2435 15 System System NNP cord-023095-4dannjjm 2435 16 ( ( -LRB- cord-023095-4dannjjm 2435 17 Promega Promega NNP cord-023095-4dannjjm 2435 18 , , , cord-023095-4dannjjm 2435 19 UK UK NNP cord-023095-4dannjjm 2435 20 ) ) -RRB- cord-023095-4dannjjm 2435 21 according accord VBG cord-023095-4dannjjm 2435 22 to to IN cord-023095-4dannjjm 2435 23 the the DT cord-023095-4dannjjm 2435 24 manufacturer manufacturer NN cord-023095-4dannjjm 2435 25 's 's POS cord-023095-4dannjjm 2435 26 recommendations recommendation NNS cord-023095-4dannjjm 2435 27 . . . cord-023095-4dannjjm 2436 1 The the DT cord-023095-4dannjjm 2436 2 supernatants supernatant NNS cord-023095-4dannjjm 2436 3 were be VBD cord-023095-4dannjjm 2436 4 harvested harvest VBN cord-023095-4dannjjm 2436 5 and and CC cord-023095-4dannjjm 2436 6 used use VBN cord-023095-4dannjjm 2436 7 in in IN cord-023095-4dannjjm 2436 8 an an DT cord-023095-4dannjjm 2436 9 IL-8 IL-8 NNP cord-023095-4dannjjm 2436 10 ELISA ELISA NNP cord-023095-4dannjjm 2436 11 ( ( -LRB- cord-023095-4dannjjm 2436 12 R&D R&D NNP cord-023095-4dannjjm 2436 13 Systems Systems NNP cord-023095-4dannjjm 2436 14 ) ) -RRB- cord-023095-4dannjjm 2436 15 . . . cord-023095-4dannjjm 2437 1 Human Human NNP cord-023095-4dannjjm 2437 2 TLR5 TLR5 NNP cord-023095-4dannjjm 2437 3 transfected transfecte VBN cord-023095-4dannjjm 2437 4 HEK HEK NNP cord-023095-4dannjjm 2437 5 cells cell NNS cord-023095-4dannjjm 2437 6 ( ( -LRB- cord-023095-4dannjjm 2437 7 Invivogen Invivogen NNP cord-023095-4dannjjm 2437 8 ) ) -RRB- cord-023095-4dannjjm 2437 9 served serve VBD cord-023095-4dannjjm 2437 10 as as IN cord-023095-4dannjjm 2437 11 positive positive JJ cord-023095-4dannjjm 2437 12 controls control NNS cord-023095-4dannjjm 2437 13 in in IN cord-023095-4dannjjm 2437 14 all all DT cord-023095-4dannjjm 2437 15 experiments experiment NNS cord-023095-4dannjjm 2437 16 . . . cord-023095-4dannjjm 2438 1 Independent Independent NNP cord-023095-4dannjjm 2438 2 T t NN cord-023095-4dannjjm 2438 3 - - HYPH cord-023095-4dannjjm 2438 4 test test NN cord-023095-4dannjjm 2438 5 was be VBD cord-023095-4dannjjm 2438 6 used use VBN cord-023095-4dannjjm 2438 7 to to TO cord-023095-4dannjjm 2438 8 determine determine VB cord-023095-4dannjjm 2438 9 the the DT cord-023095-4dannjjm 2438 10 significance significance NN cord-023095-4dannjjm 2438 11 of of IN cord-023095-4dannjjm 2438 12 relative relative JJ cord-023095-4dannjjm 2438 13 luciferase luciferase NN cord-023095-4dannjjm 2438 14 activity activity NN cord-023095-4dannjjm 2438 15 and and CC cord-023095-4dannjjm 2438 16 IL-8 il-8 NN cord-023095-4dannjjm 2438 17 concentration concentration NN cord-023095-4dannjjm 2438 18 between between IN cord-023095-4dannjjm 2438 19 wild wild JJ cord-023095-4dannjjm 2438 20 - - HYPH cord-023095-4dannjjm 2438 21 type type NN cord-023095-4dannjjm 2438 22 and and CC cord-023095-4dannjjm 2438 23 mutated mutate VBN cord-023095-4dannjjm 2438 24 TLR5 TLR5 NNP cord-023095-4dannjjm 2438 25 cells cell NNS cord-023095-4dannjjm 2438 26 . . . cord-023095-4dannjjm 2439 1 Although although IN cord-023095-4dannjjm 2439 2 there there EX cord-023095-4dannjjm 2439 3 was be VBD cord-023095-4dannjjm 2439 4 no no DT cord-023095-4dannjjm 2439 5 significant significant JJ cord-023095-4dannjjm 2439 6 difference difference NN cord-023095-4dannjjm 2439 7 between between IN cord-023095-4dannjjm 2439 8 the the DT cord-023095-4dannjjm 2439 9 wild wild JJ cord-023095-4dannjjm 2439 10 - - HYPH cord-023095-4dannjjm 2439 11 type type NN cord-023095-4dannjjm 2439 12 and and CC cord-023095-4dannjjm 2439 13 mutated mutate VBN cord-023095-4dannjjm 2439 14 receptor receptor NN cord-023095-4dannjjm 2439 15 when when WRB cord-023095-4dannjjm 2439 16 they -PRON- PRP cord-023095-4dannjjm 2439 17 were be VBD cord-023095-4dannjjm 2439 18 stimulated stimulate VBN cord-023095-4dannjjm 2439 19 with with IN cord-023095-4dannjjm 2439 20 0.01 0.01 CD cord-023095-4dannjjm 2439 21 mg mg NNP cord-023095-4dannjjm 2439 22 / / SYM cord-023095-4dannjjm 2439 23 ml ml NNS cord-023095-4dannjjm 2439 24 of of IN cord-023095-4dannjjm 2439 25 flagellin flagellin NNP cord-023095-4dannjjm 2439 26 ( ( -LRB- cord-023095-4dannjjm 2439 27 p p NN cord-023095-4dannjjm 2439 28 5 5 CD cord-023095-4dannjjm 2439 29 0.14 0.14 CD cord-023095-4dannjjm 2439 30 ) ) -RRB- cord-023095-4dannjjm 2439 31 , , , cord-023095-4dannjjm 2439 32 there there EX cord-023095-4dannjjm 2439 33 was be VBD cord-023095-4dannjjm 2439 34 a a DT cord-023095-4dannjjm 2439 35 significant significant JJ cord-023095-4dannjjm 2439 36 increase increase NN cord-023095-4dannjjm 2439 37 when when WRB cord-023095-4dannjjm 2439 38 the the DT cord-023095-4dannjjm 2439 39 cells cell NNS cord-023095-4dannjjm 2439 40 with with IN cord-023095-4dannjjm 2439 41 mutated mutate VBN cord-023095-4dannjjm 2439 42 TLR5 TLR5 NNP cord-023095-4dannjjm 2439 43 were be VBD cord-023095-4dannjjm 2439 44 stimulated stimulate VBN cord-023095-4dannjjm 2439 45 with with IN cord-023095-4dannjjm 2439 46 0.1 0.1 CD cord-023095-4dannjjm 2439 47 mg mg NNP cord-023095-4dannjjm 2439 48 / / SYM cord-023095-4dannjjm 2439 49 ml ml NNS cord-023095-4dannjjm 2439 50 of of IN cord-023095-4dannjjm 2439 51 flagellin flagellin NN cord-023095-4dannjjm 2439 52 compared compare VBN cord-023095-4dannjjm 2439 53 to to IN cord-023095-4dannjjm 2439 54 the the DT cord-023095-4dannjjm 2439 55 cells cell NNS cord-023095-4dannjjm 2439 56 expressing express VBG cord-023095-4dannjjm 2439 57 wild wild JJ cord-023095-4dannjjm 2439 58 - - HYPH cord-023095-4dannjjm 2439 59 type type NN cord-023095-4dannjjm 2439 60 TLR5 TLR5 NNP cord-023095-4dannjjm 2439 61 ( ( -LRB- cord-023095-4dannjjm 2439 62 p p NN cord-023095-4dannjjm 2439 63 5 5 CD cord-023095-4dannjjm 2439 64 0.027 0.027 CD cord-023095-4dannjjm 2439 65 ) ) -RRB- cord-023095-4dannjjm 2439 66 . . . cord-023095-4dannjjm 2440 1 Similarly similarly RB cord-023095-4dannjjm 2440 2 , , , cord-023095-4dannjjm 2440 3 there there EX cord-023095-4dannjjm 2440 4 was be VBD cord-023095-4dannjjm 2440 5 a a DT cord-023095-4dannjjm 2440 6 significant significant JJ cord-023095-4dannjjm 2440 7 increase increase NN cord-023095-4dannjjm 2440 8 in in IN cord-023095-4dannjjm 2440 9 IL-8 IL-8 NNP cord-023095-4dannjjm 2440 10 concentration concentration NN cord-023095-4dannjjm 2440 11 in in IN cord-023095-4dannjjm 2440 12 the the DT cord-023095-4dannjjm 2440 13 supernatants supernatant NNS cord-023095-4dannjjm 2440 14 in in IN cord-023095-4dannjjm 2440 15 the the DT cord-023095-4dannjjm 2440 16 cells cell NNS cord-023095-4dannjjm 2440 17 with with IN cord-023095-4dannjjm 2440 18 the the DT cord-023095-4dannjjm 2440 19 mutated mutate VBN cord-023095-4dannjjm 2440 20 TLR5 TLR5 NNP cord-023095-4dannjjm 2440 21 receptor receptor NN cord-023095-4dannjjm 2440 22 when when WRB cord-023095-4dannjjm 2440 23 stimulated stimulate VBN cord-023095-4dannjjm 2440 24 with with IN cord-023095-4dannjjm 2440 25 0.1 0.1 CD cord-023095-4dannjjm 2440 26 mg mg NNP cord-023095-4dannjjm 2440 27 / / SYM cord-023095-4dannjjm 2440 28 ml ml FW cord-023095-4dannjjm 2440 29 flagellin flagellin NN cord-023095-4dannjjm 2440 30 compared compare VBN cord-023095-4dannjjm 2440 31 to to IN cord-023095-4dannjjm 2440 32 the the DT cord-023095-4dannjjm 2440 33 wild wild JJ cord-023095-4dannjjm 2440 34 - - HYPH cord-023095-4dannjjm 2440 35 type type NN cord-023095-4dannjjm 2440 36 ( ( -LRB- cord-023095-4dannjjm 2440 37 p p NN cord-023095-4dannjjm 2440 38 5 5 CD cord-023095-4dannjjm 2440 39 0.025-one 0.025-one CD cord-023095-4dannjjm 2440 40 - - HYPH cord-023095-4dannjjm 2440 41 tailed tailed JJ cord-023095-4dannjjm 2440 42 , , , cord-023095-4dannjjm 2440 43 0.05-two 0.05-two CD cord-023095-4dannjjm 2440 44 - - HYPH cord-023095-4dannjjm 2440 45 tailed tailed JJ cord-023095-4dannjjm 2440 46 ) ) -RRB- cord-023095-4dannjjm 2440 47 but but CC cord-023095-4dannjjm 2440 48 not not RB cord-023095-4dannjjm 2440 49 with with IN cord-023095-4dannjjm 2440 50 0.01 0.01 CD cord-023095-4dannjjm 2440 51 mg mg NNP cord-023095-4dannjjm 2440 52 / / SYM cord-023095-4dannjjm 2440 53 ml ml FW cord-023095-4dannjjm 2440 54 flagellin flagellin NNP cord-023095-4dannjjm 2440 55 ( ( -LRB- cord-023095-4dannjjm 2440 56 p p NN cord-023095-4dannjjm 2440 57 5 5 CD cord-023095-4dannjjm 2440 58 0.26 0.26 CD cord-023095-4dannjjm 2440 59 ) ) -RRB- cord-023095-4dannjjm 2440 60 . . . cord-023095-4dannjjm 2441 1 We -PRON- PRP cord-023095-4dannjjm 2441 2 show show VBP cord-023095-4dannjjm 2441 3 for for IN cord-023095-4dannjjm 2441 4 the the DT cord-023095-4dannjjm 2441 5 first first JJ cord-023095-4dannjjm 2441 6 time time NN cord-023095-4dannjjm 2441 7 that that WDT cord-023095-4dannjjm 2441 8 polymorphisms polymorphism NNS cord-023095-4dannjjm 2441 9 associated associate VBN cord-023095-4dannjjm 2441 10 with with IN cord-023095-4dannjjm 2441 11 IBD IBD NNP cord-023095-4dannjjm 2441 12 are be VBP cord-023095-4dannjjm 2441 13 functionally functionally RB cord-023095-4dannjjm 2441 14 hyper hyper JJ cord-023095-4dannjjm 2441 15 - - JJ cord-023095-4dannjjm 2441 16 responsive responsive JJ cord-023095-4dannjjm 2441 17 to to TO cord-023095-4dannjjm 2441 18 flagellin flagellin VB cord-023095-4dannjjm 2441 19 compared compare VBN cord-023095-4dannjjm 2441 20 to to IN cord-023095-4dannjjm 2441 21 the the DT cord-023095-4dannjjm 2441 22 wild wild JJ cord-023095-4dannjjm 2441 23 - - HYPH cord-023095-4dannjjm 2441 24 type type NN cord-023095-4dannjjm 2441 25 receptor receptor NN cord-023095-4dannjjm 2441 26 . . . cord-023095-4dannjjm 2442 1 This this DT cord-023095-4dannjjm 2442 2 suggests suggest VBZ cord-023095-4dannjjm 2442 3 that that IN cord-023095-4dannjjm 2442 4 TLR5 TLR5 NNP cord-023095-4dannjjm 2442 5 may may MD cord-023095-4dannjjm 2442 6 play play VB cord-023095-4dannjjm 2442 7 a a DT cord-023095-4dannjjm 2442 8 role role NN cord-023095-4dannjjm 2442 9 in in IN cord-023095-4dannjjm 2442 10 canine canine JJ cord-023095-4dannjjm 2442 11 IBD IBD NNP cord-023095-4dannjjm 2442 12 and and CC cord-023095-4dannjjm 2442 13 that that IN cord-023095-4dannjjm 2442 14 blocking block VBG cord-023095-4dannjjm 2442 15 the the DT cord-023095-4dannjjm 2442 16 hyper hyper JJ cord-023095-4dannjjm 2442 17 - - JJ cord-023095-4dannjjm 2442 18 responsive responsive JJ cord-023095-4dannjjm 2442 19 receptor receptor NN cord-023095-4dannjjm 2442 20 found find VBN cord-023095-4dannjjm 2442 21 in in IN cord-023095-4dannjjm 2442 22 susceptible susceptible JJ cord-023095-4dannjjm 2442 23 dogs dog NNS cord-023095-4dannjjm 2442 24 with with IN cord-023095-4dannjjm 2442 25 IBD IBD NNP cord-023095-4dannjjm 2442 26 may may MD cord-023095-4dannjjm 2442 27 alleviate alleviate VB cord-023095-4dannjjm 2442 28 the the DT cord-023095-4dannjjm 2442 29 inappropriate inappropriate JJ cord-023095-4dannjjm 2442 30 inflammation inflammation NN cord-023095-4dannjjm 2442 31 seen see VBN cord-023095-4dannjjm 2442 32 in in IN cord-023095-4dannjjm 2442 33 this this DT cord-023095-4dannjjm 2442 34 disease disease NN cord-023095-4dannjjm 2442 35 . . . cord-023095-4dannjjm 2443 1 However however RB cord-023095-4dannjjm 2443 2 , , , cord-023095-4dannjjm 2443 3 further far RBR cord-023095-4dannjjm 2443 4 in in IN cord-023095-4dannjjm 2443 5 - - HYPH cord-023095-4dannjjm 2443 6 vivo vivo NN cord-023095-4dannjjm 2443 7 functional functional JJ cord-023095-4dannjjm 2443 8 analysis analysis NN cord-023095-4dannjjm 2443 9 of of IN cord-023095-4dannjjm 2443 10 TLR5 TLR5 NNP cord-023095-4dannjjm 2443 11 , , , cord-023095-4dannjjm 2443 12 especially especially RB cord-023095-4dannjjm 2443 13 at at IN cord-023095-4dannjjm 2443 14 the the DT cord-023095-4dannjjm 2443 15 intestinal intestinal JJ cord-023095-4dannjjm 2443 16 mucosal mucosal JJ cord-023095-4dannjjm 2443 17 level level NN cord-023095-4dannjjm 2443 18 would would MD cord-023095-4dannjjm 2443 19 be be VB cord-023095-4dannjjm 2443 20 needed need VBN cord-023095-4dannjjm 2443 21 to to TO cord-023095-4dannjjm 2443 22 confirm confirm VB cord-023095-4dannjjm 2443 23 these these DT cord-023095-4dannjjm 2443 24 findings finding NNS cord-023095-4dannjjm 2443 25 and and CC cord-023095-4dannjjm 2443 26 predict predict VB cord-023095-4dannjjm 2443 27 the the DT cord-023095-4dannjjm 2443 28 usefulness usefulness NN cord-023095-4dannjjm 2443 29 of of IN cord-023095-4dannjjm 2443 30 any any DT cord-023095-4dannjjm 2443 31 future future JJ cord-023095-4dannjjm 2443 32 therapeutic therapeutic JJ cord-023095-4dannjjm 2443 33 interventions intervention NNS cord-023095-4dannjjm 2443 34 . . . cord-023095-4dannjjm 2444 1 TLR5 TLR5 NNP cord-023095-4dannjjm 2444 2 has have VBZ cord-023095-4dannjjm 2444 3 been be VBN cord-023095-4dannjjm 2444 4 shown show VBN cord-023095-4dannjjm 2444 5 to to TO cord-023095-4dannjjm 2444 6 play play VB cord-023095-4dannjjm 2444 7 a a DT cord-023095-4dannjjm 2444 8 role role NN cord-023095-4dannjjm 2444 9 in in IN cord-023095-4dannjjm 2444 10 the the DT cord-023095-4dannjjm 2444 11 inappropriate inappropriate JJ cord-023095-4dannjjm 2444 12 inflammation inflammation NN cord-023095-4dannjjm 2444 13 seen see VBN cord-023095-4dannjjm 2444 14 in in IN cord-023095-4dannjjm 2444 15 human human JJ cord-023095-4dannjjm 2444 16 inflammatory inflammatory JJ cord-023095-4dannjjm 2444 17 bowel bowel NN cord-023095-4dannjjm 2444 18 disease disease NN cord-023095-4dannjjm 2444 19 ( ( -LRB- cord-023095-4dannjjm 2444 20 IBD IBD NNP cord-023095-4dannjjm 2444 21 ) ) -RRB- cord-023095-4dannjjm 2444 22 . . . cord-023095-4dannjjm 2445 1 Similarly similarly RB cord-023095-4dannjjm 2445 2 , , , cord-023095-4dannjjm 2445 3 we -PRON- PRP cord-023095-4dannjjm 2445 4 have have VBP cord-023095-4dannjjm 2445 5 recently recently RB cord-023095-4dannjjm 2445 6 demonstrated demonstrate VBN cord-023095-4dannjjm 2445 7 a a DT cord-023095-4dannjjm 2445 8 significant significant JJ cord-023095-4dannjjm 2445 9 association association NN cord-023095-4dannjjm 2445 10 between between IN cord-023095-4dannjjm 2445 11 three three CD cord-023095-4dannjjm 2445 12 non non JJ cord-023095-4dannjjm 2445 13 - - JJ cord-023095-4dannjjm 2445 14 synonymous synonymous JJ cord-023095-4dannjjm 2445 15 single single JJ cord-023095-4dannjjm 2445 16 nucleotide nucleotide JJ cord-023095-4dannjjm 2445 17 polymorphisms polymorphism NNS cord-023095-4dannjjm 2445 18 ( ( -LRB- cord-023095-4dannjjm 2445 19 SNPs SNPs NNP cord-023095-4dannjjm 2445 20 ) ) -RRB- cord-023095-4dannjjm 2445 21 in in IN cord-023095-4dannjjm 2445 22 the the DT cord-023095-4dannjjm 2445 23 canine canine JJ cord-023095-4dannjjm 2445 24 TLR5 TLR5 NNP cord-023095-4dannjjm 2445 25 gene gene NN cord-023095-4dannjjm 2445 26 ( ( -LRB- cord-023095-4dannjjm 2445 27 G22A g22a NN cord-023095-4dannjjm 2445 28 , , , cord-023095-4dannjjm 2445 29 C100 C100 NNP cord-023095-4dannjjm 2445 30 T T NNP cord-023095-4dannjjm 2445 31 and and CC cord-023095-4dannjjm 2445 32 T1844C T1844C NNP cord-023095-4dannjjm 2445 33 ) ) -RRB- cord-023095-4dannjjm 2445 34 and and CC cord-023095-4dannjjm 2445 35 inflammatory inflammatory JJ cord-023095-4dannjjm 2445 36 bowel bowel NN cord-023095-4dannjjm 2445 37 disease disease NN cord-023095-4dannjjm 2445 38 ( ( -LRB- cord-023095-4dannjjm 2445 39 IBD IBD NNP cord-023095-4dannjjm 2445 40 ) ) -RRB- cord-023095-4dannjjm 2445 41 in in IN cord-023095-4dannjjm 2445 42 German german JJ cord-023095-4dannjjm 2445 43 shepherd shepherd NN cord-023095-4dannjjm 2445 44 dogs dog NNS cord-023095-4dannjjm 2445 45 ( ( -LRB- cord-023095-4dannjjm 2445 46 GSDs GSDs NNP cord-023095-4dannjjm 2445 47 ) ) -RRB- cord-023095-4dannjjm 2445 48 . . . cord-023095-4dannjjm 2446 1 Therefore therefore RB cord-023095-4dannjjm 2446 2 the the DT cord-023095-4dannjjm 2446 3 aim aim NN cord-023095-4dannjjm 2446 4 of of IN cord-023095-4dannjjm 2446 5 this this DT cord-023095-4dannjjm 2446 6 study study NN cord-023095-4dannjjm 2446 7 was be VBD cord-023095-4dannjjm 2446 8 to to TO cord-023095-4dannjjm 2446 9 determine determine VB cord-023095-4dannjjm 2446 10 the the DT cord-023095-4dannjjm 2446 11 functional functional JJ cord-023095-4dannjjm 2446 12 significance significance NN cord-023095-4dannjjm 2446 13 of of IN cord-023095-4dannjjm 2446 14 the the DT cord-023095-4dannjjm 2446 15 TLR5 TLR5 NNP cord-023095-4dannjjm 2446 16 SNPs snp NNS cord-023095-4dannjjm 2446 17 in in IN cord-023095-4dannjjm 2446 18 the the DT cord-023095-4dannjjm 2446 19 breed breed NN cord-023095-4dannjjm 2446 20 of of IN cord-023095-4dannjjm 2446 21 GSDs gsds NN cord-023095-4dannjjm 2446 22 . . . cord-023095-4dannjjm 2447 1 The the DT cord-023095-4dannjjm 2447 2 TLR5 TLR5 NNP cord-023095-4dannjjm 2447 3 gene gene NN cord-023095-4dannjjm 2447 4 containing contain VBG cord-023095-4dannjjm 2447 5 the the DT cord-023095-4dannjjm 2447 6 risk risk NN cord-023095-4dannjjm 2447 7 haplotype haplotype NN cord-023095-4dannjjm 2447 8 for for IN cord-023095-4dannjjm 2447 9 IBD IBD NNP cord-023095-4dannjjm 2447 10 ( ( -LRB- cord-023095-4dannjjm 2447 11 ACC ACC NNP cord-023095-4dannjjm 2447 12 ) ) -RRB- cord-023095-4dannjjm 2447 13 and and CC cord-023095-4dannjjm 2447 14 wild wild JJ cord-023095-4dannjjm 2447 15 - - HYPH cord-023095-4dannjjm 2447 16 type type NN cord-023095-4dannjjm 2447 17 haplotype haplotype NN cord-023095-4dannjjm 2447 18 ( ( -LRB- cord-023095-4dannjjm 2447 19 GTT GTT NNP cord-023095-4dannjjm 2447 20 ) ) -RRB- cord-023095-4dannjjm 2447 21 were be VBD cord-023095-4dannjjm 2447 22 stably stably RB cord-023095-4dannjjm 2447 23 transfected transfecte VBN cord-023095-4dannjjm 2447 24 into into IN cord-023095-4dannjjm 2447 25 HEK HEK NNP cord-023095-4dannjjm 2447 26 cells cell NNS cord-023095-4dannjjm 2447 27 . . . cord-023095-4dannjjm 2448 1 NF NF NNP cord-023095-4dannjjm 2448 2 - - HYPH cord-023095-4dannjjm 2448 3 kB kb CD cord-023095-4dannjjm 2448 4 activity activity NN cord-023095-4dannjjm 2448 5 was be VBD cord-023095-4dannjjm 2448 6 measured measure VBN cord-023095-4dannjjm 2448 7 by by IN cord-023095-4dannjjm 2448 8 transiently transiently RB cord-023095-4dannjjm 2448 9 transfecting transfecte VBG cord-023095-4dannjjm 2448 10 the the DT cord-023095-4dannjjm 2448 11 cells cell NNS cord-023095-4dannjjm 2448 12 with with IN cord-023095-4dannjjm 2448 13 NF NF NNP cord-023095-4dannjjm 2448 14 - - HYPH cord-023095-4dannjjm 2448 15 kB kb CD cord-023095-4dannjjm 2448 16 firefly firefly NN cord-023095-4dannjjm 2448 17 and and CC cord-023095-4dannjjm 2448 18 HSV HSV NNP cord-023095-4dannjjm 2448 19 - - HYPH cord-023095-4dannjjm 2448 20 thymidine thymidine NN cord-023095-4dannjjm 2448 21 kinase kinase NN cord-023095-4dannjjm 2448 22 promoter promoter NN cord-023095-4dannjjm 2448 23 ( ( -LRB- cord-023095-4dannjjm 2448 24 pRL pRL NNP cord-023095-4dannjjm 2448 25 - - HYPH cord-023095-4dannjjm 2448 26 TK TK NNP cord-023095-4dannjjm 2448 27 ) ) -RRB- cord-023095-4dannjjm 2448 28 renilla renilla NNP cord-023095-4dannjjm 2448 29 plasmids plasmid NNS cord-023095-4dannjjm 2448 30 . . . cord-023095-4dannjjm 2449 1 The the DT cord-023095-4dannjjm 2449 2 cells cell NNS cord-023095-4dannjjm 2449 3 were be VBD cord-023095-4dannjjm 2449 4 stimulated stimulate VBN cord-023095-4dannjjm 2449 5 with with IN cord-023095-4dannjjm 2449 6 various various JJ cord-023095-4dannjjm 2449 7 TLR TLR NNP cord-023095-4dannjjm 2449 8 ligands ligand NNS cord-023095-4dannjjm 2449 9 ( ( -LRB- cord-023095-4dannjjm 2449 10 0.1 0.1 CD cord-023095-4dannjjm 2449 11 mg/ mg/ NN cord-023095-4dannjjm 2449 12 ml ml NNP cord-023095-4dannjjm 2449 13 flagellin flagellin NNP cord-023095-4dannjjm 2449 14 , , , cord-023095-4dannjjm 2449 15 0.01 0.01 CD cord-023095-4dannjjm 2449 16 mg mg NNP cord-023095-4dannjjm 2449 17 / / SYM cord-023095-4dannjjm 2449 18 ml ml NNP cord-023095-4dannjjm 2449 19 flagellin flagellin NNP cord-023095-4dannjjm 2449 20 , , , cord-023095-4dannjjm 2449 21 1 1 CD cord-023095-4dannjjm 2449 22 mg mg NNP cord-023095-4dannjjm 2449 23 / / SYM cord-023095-4dannjjm 2449 24 ml ml NNP cord-023095-4dannjjm 2449 25 LPS LPS NNP cord-023095-4dannjjm 2449 26 , , , cord-023095-4dannjjm 2449 27 1 1 CD cord-023095-4dannjjm 2449 28 mg mg NNP cord-023095-4dannjjm 2449 29 / / SYM cord-023095-4dannjjm 2449 30 ml ml NNP cord-023095-4dannjjm 2449 31 PAM3CSK PAM3CSK NNP cord-023095-4dannjjm 2449 32 and and CC cord-023095-4dannjjm 2449 33 media medium NNS cord-023095-4dannjjm 2449 34 control control NN cord-023095-4dannjjm 2449 35 ) ) -RRB- cord-023095-4dannjjm 2449 36 . . . cord-023095-4dannjjm 2450 1 Firefly Firefly NNP cord-023095-4dannjjm 2450 2 and and CC cord-023095-4dannjjm 2450 3 renilla renilla NNP cord-023095-4dannjjm 2450 4 luciferase luciferase NN cord-023095-4dannjjm 2450 5 activities activity NNS cord-023095-4dannjjm 2450 6 were be VBD cord-023095-4dannjjm 2450 7 measured measure VBN cord-023095-4dannjjm 2450 8 using use VBG cord-023095-4dannjjm 2450 9 the the DT cord-023095-4dannjjm 2450 10 Dual Dual NNP cord-023095-4dannjjm 2450 11 - - HYPH cord-023095-4dannjjm 2450 12 Glo Glo NNP cord-023095-4dannjjm 2450 13 Luciferase Luciferase NNP cord-023095-4dannjjm 2450 14 Assay Assay NNP cord-023095-4dannjjm 2450 15 System System NNP cord-023095-4dannjjm 2450 16 ( ( -LRB- cord-023095-4dannjjm 2450 17 Promega Promega NNP cord-023095-4dannjjm 2450 18 , , , cord-023095-4dannjjm 2450 19 UK UK NNP cord-023095-4dannjjm 2450 20 ) ) -RRB- cord-023095-4dannjjm 2450 21 . . . cord-023095-4dannjjm 2451 1 The the DT cord-023095-4dannjjm 2451 2 supernatants supernatant NNS cord-023095-4dannjjm 2451 3 were be VBD cord-023095-4dannjjm 2451 4 harvested harvest VBN cord-023095-4dannjjm 2451 5 and and CC cord-023095-4dannjjm 2451 6 used use VBN cord-023095-4dannjjm 2451 7 in in IN cord-023095-4dannjjm 2451 8 an an DT cord-023095-4dannjjm 2451 9 IL-8 IL-8 NNP cord-023095-4dannjjm 2451 10 ELISA ELISA NNP cord-023095-4dannjjm 2451 11 ( ( -LRB- cord-023095-4dannjjm 2451 12 R&D R&D NNP cord-023095-4dannjjm 2451 13 Systems Systems NNP cord-023095-4dannjjm 2451 14 ) ) -RRB- cord-023095-4dannjjm 2451 15 . . . cord-023095-4dannjjm 2452 1 Peripheral peripheral JJ cord-023095-4dannjjm 2452 2 whole whole JJ cord-023095-4dannjjm 2452 3 blood blood NN cord-023095-4dannjjm 2452 4 from from IN cord-023095-4dannjjm 2452 5 dogs dog NNS cord-023095-4dannjjm 2452 6 carrying carry VBG cord-023095-4dannjjm 2452 7 the the DT cord-023095-4dannjjm 2452 8 wild wild JJ cord-023095-4dannjjm 2452 9 type type NN cord-023095-4dannjjm 2452 10 and and CC cord-023095-4dannjjm 2452 11 mutant mutant JJ cord-023095-4dannjjm 2452 12 TLR5 TLR5 NNP cord-023095-4dannjjm 2452 13 genes gene NNS cord-023095-4dannjjm 2452 14 was be VBD cord-023095-4dannjjm 2452 15 cultured cultured JJ cord-023095-4dannjjm 2452 16 and and CC cord-023095-4dannjjm 2452 17 stimulated stimulate VBN cord-023095-4dannjjm 2452 18 with with IN cord-023095-4dannjjm 2452 19 TLR TLR NNP cord-023095-4dannjjm 2452 20 ligands ligand NNS cord-023095-4dannjjm 2452 21 as as IN cord-023095-4dannjjm 2452 22 above above RB cord-023095-4dannjjm 2452 23 . . . cord-023095-4dannjjm 2453 1 Canine Canine NNP cord-023095-4dannjjm 2453 2 TNF TNF NNP cord-023095-4dannjjm 2453 3 - - HYPH cord-023095-4dannjjm 2453 4 alpha alpha NN cord-023095-4dannjjm 2453 5 was be VBD cord-023095-4dannjjm 2453 6 measured measure VBN cord-023095-4dannjjm 2453 7 in in IN cord-023095-4dannjjm 2453 8 the the DT cord-023095-4dannjjm 2453 9 supernatant supernatant NN cord-023095-4dannjjm 2453 10 by by IN cord-023095-4dannjjm 2453 11 commercially commercially RB cord-023095-4dannjjm 2453 12 available available JJ cord-023095-4dannjjm 2453 13 ELISA ELISA NNP cord-023095-4dannjjm 2453 14 ( ( -LRB- cord-023095-4dannjjm 2453 15 R&D R&D NNP cord-023095-4dannjjm 2453 16 Systems Systems NNP cord-023095-4dannjjm 2453 17 ) ) -RRB- cord-023095-4dannjjm 2453 18 . . . cord-023095-4dannjjm 2454 1 T t NN cord-023095-4dannjjm 2454 2 - - HYPH cord-023095-4dannjjm 2454 3 test test NN cord-023095-4dannjjm 2454 4 was be VBD cord-023095-4dannjjm 2454 5 used use VBN cord-023095-4dannjjm 2454 6 to to TO cord-023095-4dannjjm 2454 7 determine determine VB cord-023095-4dannjjm 2454 8 differences difference NNS cord-023095-4dannjjm 2454 9 of of IN cord-023095-4dannjjm 2454 10 relative relative JJ cord-023095-4dannjjm 2454 11 luciferase luciferase NN cord-023095-4dannjjm 2454 12 activity activity NN cord-023095-4dannjjm 2454 13 , , , cord-023095-4dannjjm 2454 14 IL-8 IL-8 NNP cord-023095-4dannjjm 2454 15 concentration concentration NN cord-023095-4dannjjm 2454 16 and and CC cord-023095-4dannjjm 2454 17 TNF tnf NN cord-023095-4dannjjm 2454 18 - - HYPH cord-023095-4dannjjm 2454 19 alpha alpha NN cord-023095-4dannjjm 2454 20 concentration concentration NN cord-023095-4dannjjm 2454 21 between between IN cord-023095-4dannjjm 2454 22 wild wild JJ cord-023095-4dannjjm 2454 23 - - HYPH cord-023095-4dannjjm 2454 24 type type NN cord-023095-4dannjjm 2454 25 and and CC cord-023095-4dannjjm 2454 26 mutated mutate VBN cord-023095-4dannjjm 2454 27 TLR5 TLR5 NNP cord-023095-4dannjjm 2454 28 cells cell NNS cord-023095-4dannjjm 2454 29 . . . cord-023095-4dannjjm 2455 1 There there EX cord-023095-4dannjjm 2455 2 was be VBD cord-023095-4dannjjm 2455 3 a a DT cord-023095-4dannjjm 2455 4 significant significant JJ cord-023095-4dannjjm 2455 5 increase increase NN cord-023095-4dannjjm 2455 6 in in IN cord-023095-4dannjjm 2455 7 NF NF NNP cord-023095-4dannjjm 2455 8 - - HYPH cord-023095-4dannjjm 2455 9 kB kb CD cord-023095-4dannjjm 2455 10 activity activity NN cord-023095-4dannjjm 2455 11 when when WRB cord-023095-4dannjjm 2455 12 the the DT cord-023095-4dannjjm 2455 13 cells cell NNS cord-023095-4dannjjm 2455 14 with with IN cord-023095-4dannjjm 2455 15 mutated mutate VBN cord-023095-4dannjjm 2455 16 TLR5 TLR5 NNP cord-023095-4dannjjm 2455 17 were be VBD cord-023095-4dannjjm 2455 18 stimulated stimulate VBN cord-023095-4dannjjm 2455 19 with with IN cord-023095-4dannjjm 2455 20 0.1 0.1 CD cord-023095-4dannjjm 2455 21 mg mg NNP cord-023095-4dannjjm 2455 22 / / SYM cord-023095-4dannjjm 2455 23 ml ml NNS cord-023095-4dannjjm 2455 24 of of IN cord-023095-4dannjjm 2455 25 flagellin flagellin NN cord-023095-4dannjjm 2455 26 compared compare VBN cord-023095-4dannjjm 2455 27 to to IN cord-023095-4dannjjm 2455 28 the the DT cord-023095-4dannjjm 2455 29 cells cell NNS cord-023095-4dannjjm 2455 30 expressing express VBG cord-023095-4dannjjm 2455 31 wild wild JJ cord-023095-4dannjjm 2455 32 - - HYPH cord-023095-4dannjjm 2455 33 type type NN cord-023095-4dannjjm 2455 34 TLR5 TLR5 NNP cord-023095-4dannjjm 2455 35 ( ( -LRB- cord-023095-4dannjjm 2455 36 p p NN cord-023095-4dannjjm 2455 37 5 5 CD cord-023095-4dannjjm 2455 38 0.027 0.027 CD cord-023095-4dannjjm 2455 39 ) ) -RRB- cord-023095-4dannjjm 2455 40 , , , cord-023095-4dannjjm 2455 41 which which WDT cord-023095-4dannjjm 2455 42 correlated correlate VBD cord-023095-4dannjjm 2455 43 with with IN cord-023095-4dannjjm 2455 44 IL-8 IL-8 NNP cord-023095-4dannjjm 2455 45 expression expression NN cord-023095-4dannjjm 2455 46 in in IN cord-023095-4dannjjm 2455 47 the the DT cord-023095-4dannjjm 2455 48 supernatant supernatant NN cord-023095-4dannjjm 2455 49 ( ( -LRB- cord-023095-4dannjjm 2455 50 p p NN cord-023095-4dannjjm 2455 51 5 5 CD cord-023095-4dannjjm 2455 52 0.26 0.26 CD cord-023095-4dannjjm 2455 53 ) ) -RRB- cord-023095-4dannjjm 2455 54 . . . cord-023095-4dannjjm 2456 1 Similarly similarly RB cord-023095-4dannjjm 2456 2 , , , cord-023095-4dannjjm 2456 3 in in IN cord-023095-4dannjjm 2456 4 the the DT cord-023095-4dannjjm 2456 5 whole whole JJ cord-023095-4dannjjm 2456 6 blood blood NN cord-023095-4dannjjm 2456 7 assay assay NN cord-023095-4dannjjm 2456 8 the the DT cord-023095-4dannjjm 2456 9 TLR5 TLR5 NNP cord-023095-4dannjjm 2456 10 risk risk NN cord-023095-4dannjjm 2456 11 haplotype haplotype NN cord-023095-4dannjjm 2456 12 for for IN cord-023095-4dannjjm 2456 13 IBD IBD NNP cord-023095-4dannjjm 2456 14 in in IN cord-023095-4dannjjm 2456 15 GSDs gsds NN cord-023095-4dannjjm 2456 16 ( ( -LRB- cord-023095-4dannjjm 2456 17 ACC ACC NNP cord-023095-4dannjjm 2456 18 ) ) -RRB- cord-023095-4dannjjm 2456 19 was be VBD cord-023095-4dannjjm 2456 20 significantly significantly RB cord-023095-4dannjjm 2456 21 hyperresponsive hyperresponsive NNP cord-023095-4dannjjm 2456 22 to to TO cord-023095-4dannjjm 2456 23 flagellin flagellin VB cord-023095-4dannjjm 2456 24 at at IN cord-023095-4dannjjm 2456 25 a a DT cord-023095-4dannjjm 2456 26 concentration concentration NN cord-023095-4dannjjm 2456 27 of of IN cord-023095-4dannjjm 2456 28 0.1 0.1 CD cord-023095-4dannjjm 2456 29 mg mg NNP cord-023095-4dannjjm 2456 30 / / SYM cord-023095-4dannjjm 2456 31 ml ml NNS cord-023095-4dannjjm 2456 32 compared compare VBN cord-023095-4dannjjm 2456 33 to to IN cord-023095-4dannjjm 2456 34 the the DT cord-023095-4dannjjm 2456 35 TLR5 TLR5 NNP cord-023095-4dannjjm 2456 36 wild wild JJ cord-023095-4dannjjm 2456 37 - - HYPH cord-023095-4dannjjm 2456 38 type type NN cord-023095-4dannjjm 2456 39 haplotype haplotype NN cord-023095-4dannjjm 2456 40 ( ( -LRB- cord-023095-4dannjjm 2456 41 GTT GTT NNP cord-023095-4dannjjm 2456 42 ) ) -RRB- cord-023095-4dannjjm 2457 1 ( ( -LRB- cord-023095-4dannjjm 2457 2 p p NN cord-023095-4dannjjm 2457 3 5 5 CD cord-023095-4dannjjm 2457 4 0.001 0.001 CD cord-023095-4dannjjm 2457 5 ) ) -RRB- cord-023095-4dannjjm 2457 6 . . . cord-023095-4dannjjm 2458 1 We -PRON- PRP cord-023095-4dannjjm 2458 2 show show VBP cord-023095-4dannjjm 2458 3 for for IN cord-023095-4dannjjm 2458 4 the the DT cord-023095-4dannjjm 2458 5 first first JJ cord-023095-4dannjjm 2458 6 time time NN cord-023095-4dannjjm 2458 7 that that WDT cord-023095-4dannjjm 2458 8 polymorphisms polymorphism NNS cord-023095-4dannjjm 2458 9 associated associate VBN cord-023095-4dannjjm 2458 10 with with IN cord-023095-4dannjjm 2458 11 canine canine JJ cord-023095-4dannjjm 2458 12 IBD IBD NNP cord-023095-4dannjjm 2458 13 in in IN cord-023095-4dannjjm 2458 14 GSDs gsds NN cord-023095-4dannjjm 2458 15 are be VBP cord-023095-4dannjjm 2458 16 functionally functionally RB cord-023095-4dannjjm 2458 17 hyper hyper JJ cord-023095-4dannjjm 2458 18 - - JJ cord-023095-4dannjjm 2458 19 responsive responsive JJ cord-023095-4dannjjm 2458 20 to to TO cord-023095-4dannjjm 2458 21 flagellin flagellin VB cord-023095-4dannjjm 2458 22 compared compare VBN cord-023095-4dannjjm 2458 23 to to IN cord-023095-4dannjjm 2458 24 the the DT cord-023095-4dannjjm 2458 25 wild wild JJ cord-023095-4dannjjm 2458 26 - - HYPH cord-023095-4dannjjm 2458 27 type type NN cord-023095-4dannjjm 2458 28 receptor receptor NN cord-023095-4dannjjm 2458 29 . . . cord-023095-4dannjjm 2459 1 Blocking block VBG cord-023095-4dannjjm 2459 2 the the DT cord-023095-4dannjjm 2459 3 hyper hyper JJ cord-023095-4dannjjm 2459 4 - - JJ cord-023095-4dannjjm 2459 5 responsive responsive JJ cord-023095-4dannjjm 2459 6 receptor receptor NN cord-023095-4dannjjm 2459 7 found find VBN cord-023095-4dannjjm 2459 8 in in IN cord-023095-4dannjjm 2459 9 susceptible susceptible JJ cord-023095-4dannjjm 2459 10 dogs dog NNS cord-023095-4dannjjm 2459 11 with with IN cord-023095-4dannjjm 2459 12 IBD IBD NNP cord-023095-4dannjjm 2459 13 may may MD cord-023095-4dannjjm 2459 14 alleviate alleviate VB cord-023095-4dannjjm 2459 15 the the DT cord-023095-4dannjjm 2459 16 inappropriate inappropriate JJ cord-023095-4dannjjm 2459 17 inflammation inflammation NN cord-023095-4dannjjm 2459 18 seen see VBN cord-023095-4dannjjm 2459 19 in in IN cord-023095-4dannjjm 2459 20 this this DT cord-023095-4dannjjm 2459 21 disease disease NN cord-023095-4dannjjm 2459 22 . . . cord-023095-4dannjjm 2460 1 Proton proton NN cord-023095-4dannjjm 2460 2 pump pump NN cord-023095-4dannjjm 2460 3 inhibitors inhibitor NNS cord-023095-4dannjjm 2460 4 ( ( -LRB- cord-023095-4dannjjm 2460 5 PPI PPI NNP cord-023095-4dannjjm 2460 6 ) ) -RRB- cord-023095-4dannjjm 2460 7 are be VBP cord-023095-4dannjjm 2460 8 widely widely RB cord-023095-4dannjjm 2460 9 used use VBN cord-023095-4dannjjm 2460 10 in in IN cord-023095-4dannjjm 2460 11 human human JJ cord-023095-4dannjjm 2460 12 and and CC cord-023095-4dannjjm 2460 13 also also RB cord-023095-4dannjjm 2460 14 veterinary veterinary JJ cord-023095-4dannjjm 2460 15 medicine medicine NN cord-023095-4dannjjm 2460 16 . . . cord-023095-4dannjjm 2461 1 Side side NN cord-023095-4dannjjm 2461 2 - - HYPH cord-023095-4dannjjm 2461 3 effects effect NNS cord-023095-4dannjjm 2461 4 of of IN cord-023095-4dannjjm 2461 5 PPI PPI NNP cord-023095-4dannjjm 2461 6 treatment treatment NN cord-023095-4dannjjm 2461 7 reported report VBN cord-023095-4dannjjm 2461 8 in in IN cord-023095-4dannjjm 2461 9 people people NNS cord-023095-4dannjjm 2461 10 are be VBP cord-023095-4dannjjm 2461 11 atrophic atrophic JJ cord-023095-4dannjjm 2461 12 gastritis gastritis NN cord-023095-4dannjjm 2461 13 , , , cord-023095-4dannjjm 2461 14 gastric gastric JJ cord-023095-4dannjjm 2461 15 and and CC cord-023095-4dannjjm 2461 16 esophageal esophageal JJ cord-023095-4dannjjm 2461 17 cancer cancer NN cord-023095-4dannjjm 2461 18 , , , cord-023095-4dannjjm 2461 19 and and CC cord-023095-4dannjjm 2461 20 rebound rebound VB cord-023095-4dannjjm 2461 21 hyperacidity hyperacidity NN cord-023095-4dannjjm 2461 22 following follow VBG cord-023095-4dannjjm 2461 23 cessation cessation NN cord-023095-4dannjjm 2461 24 of of IN cord-023095-4dannjjm 2461 25 treatment treatment NN cord-023095-4dannjjm 2461 26 , , , cord-023095-4dannjjm 2461 27 which which WDT cord-023095-4dannjjm 2461 28 has have VBZ cord-023095-4dannjjm 2461 29 been be VBN cord-023095-4dannjjm 2461 30 speculated speculate VBN cord-023095-4dannjjm 2461 31 to to TO cord-023095-4dannjjm 2461 32 be be VB cord-023095-4dannjjm 2461 33 due due JJ cord-023095-4dannjjm 2461 34 to to IN cord-023095-4dannjjm 2461 35 a a DT cord-023095-4dannjjm 2461 36 sustained sustained JJ cord-023095-4dannjjm 2461 37 increased increase VBN cord-023095-4dannjjm 2461 38 in in IN cord-023095-4dannjjm 2461 39 circulating circulate VBG cord-023095-4dannjjm 2461 40 gastrin gastrin NN cord-023095-4dannjjm 2461 41 concentration concentration NN cord-023095-4dannjjm 2461 42 . . . cord-023095-4dannjjm 2462 1 Moreover moreover RB cord-023095-4dannjjm 2462 2 , , , cord-023095-4dannjjm 2462 3 long long JJ cord-023095-4dannjjm 2462 4 - - HYPH cord-023095-4dannjjm 2462 5 term term NN cord-023095-4dannjjm 2462 6 PPI PPI NNP cord-023095-4dannjjm 2462 7 treatment treatment NN cord-023095-4dannjjm 2462 8 has have VBZ cord-023095-4dannjjm 2462 9 been be VBN cord-023095-4dannjjm 2462 10 associated associate VBN cord-023095-4dannjjm 2462 11 with with IN cord-023095-4dannjjm 2462 12 an an DT cord-023095-4dannjjm 2462 13 increased increase VBN cord-023095-4dannjjm 2462 14 risk risk NN cord-023095-4dannjjm 2462 15 for for IN cord-023095-4dannjjm 2462 16 osteoporosis osteoporosis NN cord-023095-4dannjjm 2462 17 in in IN cord-023095-4dannjjm 2462 18 people people NNS cord-023095-4dannjjm 2462 19 . . . cord-023095-4dannjjm 2463 1 Little little JJ cord-023095-4dannjjm 2463 2 is be VBZ cord-023095-4dannjjm 2463 3 known know VBN cord-023095-4dannjjm 2463 4 about about IN cord-023095-4dannjjm 2463 5 the the DT cord-023095-4dannjjm 2463 6 effect effect NN cord-023095-4dannjjm 2463 7 of of IN cord-023095-4dannjjm 2463 8 PPI PPI NNP cord-023095-4dannjjm 2463 9 treatment treatment NN cord-023095-4dannjjm 2463 10 on on IN cord-023095-4dannjjm 2463 11 serum serum NN cord-023095-4dannjjm 2463 12 gastrin gastrin NN cord-023095-4dannjjm 2463 13 concentration concentration NN cord-023095-4dannjjm 2463 14 or or CC cord-023095-4dannjjm 2463 15 calcium calcium NN cord-023095-4dannjjm 2463 16 metabolism metabolism NN cord-023095-4dannjjm 2463 17 in in IN cord-023095-4dannjjm 2463 18 dogs dog NNS cord-023095-4dannjjm 2463 19 . . . cord-023095-4dannjjm 2464 1 Eight eight CD cord-023095-4dannjjm 2464 2 healthy healthy JJ cord-023095-4dannjjm 2464 3 adult adult NN cord-023095-4dannjjm 2464 4 research research NN cord-023095-4dannjjm 2464 5 dogs dog NNS cord-023095-4dannjjm 2464 6 ( ( -LRB- cord-023095-4dannjjm 2464 7 4 4 CD cord-023095-4dannjjm 2464 8 males male NNS cord-023095-4dannjjm 2464 9 and and CC cord-023095-4dannjjm 2464 10 4 4 CD cord-023095-4dannjjm 2464 11 females female NNS cord-023095-4dannjjm 2464 12 ) ) -RRB- cord-023095-4dannjjm 2464 13 were be VBD cord-023095-4dannjjm 2464 14 enrolled enrol VBN cord-023095-4dannjjm 2464 15 into into IN cord-023095-4dannjjm 2464 16 the the DT cord-023095-4dannjjm 2464 17 study study NN cord-023095-4dannjjm 2464 18 . . . cord-023095-4dannjjm 2465 1 The the DT cord-023095-4dannjjm 2465 2 dogs dog NNS cord-023095-4dannjjm 2465 3 received receive VBD cord-023095-4dannjjm 2465 4 an an DT cord-023095-4dannjjm 2465 5 average average JJ cord-023095-4dannjjm 2465 6 dose dose NN cord-023095-4dannjjm 2465 7 of of IN cord-023095-4dannjjm 2465 8 1.1 1.1 CD cord-023095-4dannjjm 2465 9 mg/ mg/ NN cord-023095-4dannjjm 2465 10 kg kg NNP cord-023095-4dannjjm 2465 11 of of IN cord-023095-4dannjjm 2465 12 omeprazole omeprazole NN cord-023095-4dannjjm 2465 13 orally orally RB cord-023095-4dannjjm 2465 14 twice twice RB cord-023095-4dannjjm 2465 15 daily daily RB cord-023095-4dannjjm 2465 16 for for IN cord-023095-4dannjjm 2465 17 15 15 CD cord-023095-4dannjjm 2465 18 days day NNS cord-023095-4dannjjm 2465 19 . . . cord-023095-4dannjjm 2466 1 Blood blood NN cord-023095-4dannjjm 2466 2 samples sample NNS cord-023095-4dannjjm 2466 3 were be VBD cord-023095-4dannjjm 2466 4 collected collect VBN cord-023095-4dannjjm 2466 5 prior prior RB cord-023095-4dannjjm 2466 6 to to IN cord-023095-4dannjjm 2466 7 initiating initiate VBG cord-023095-4dannjjm 2466 8 the the DT cord-023095-4dannjjm 2466 9 treatment treatment NN cord-023095-4dannjjm 2466 10 and and CC cord-023095-4dannjjm 2466 11 every every DT cord-023095-4dannjjm 2466 12 3 3 CD cord-023095-4dannjjm 2466 13 days day NNS cord-023095-4dannjjm 2466 14 during during IN cord-023095-4dannjjm 2466 15 the the DT cord-023095-4dannjjm 2466 16 15 15 CD cord-023095-4dannjjm 2466 17 days day NNS cord-023095-4dannjjm 2466 18 of of IN cord-023095-4dannjjm 2466 19 treatment treatment NN cord-023095-4dannjjm 2466 20 and and CC cord-023095-4dannjjm 2466 21 during during IN cord-023095-4dannjjm 2466 22 the the DT cord-023095-4dannjjm 2466 23 15 15 CD cord-023095-4dannjjm 2466 24 days day NNS cord-023095-4dannjjm 2466 25 after after IN cord-023095-4dannjjm 2466 26 discontinuation discontinuation NN cord-023095-4dannjjm 2466 27 of of IN cord-023095-4dannjjm 2466 28 treatment treatment NN cord-023095-4dannjjm 2466 29 for for IN cord-023095-4dannjjm 2466 30 determination determination NN cord-023095-4dannjjm 2466 31 of of IN cord-023095-4dannjjm 2466 32 serum serum NN cord-023095-4dannjjm 2466 33 gastrin gastrin NN cord-023095-4dannjjm 2466 34 , , , cord-023095-4dannjjm 2466 35 ionized ionized JJ cord-023095-4dannjjm 2466 36 calcium calcium NN cord-023095-4dannjjm 2466 37 , , , cord-023095-4dannjjm 2466 38 PTH PTH NNP cord-023095-4dannjjm 2466 39 , , , cord-023095-4dannjjm 2466 40 and and CC cord-023095-4dannjjm 2466 41 25 25 CD cord-023095-4dannjjm 2466 42 OH OH NNP cord-023095-4dannjjm 2466 43 vitamin vitamin NN cord-023095-4dannjjm 2466 44 D3 D3 NNP cord-023095-4dannjjm 2466 45 . . . cord-023095-4dannjjm 2467 1 Gastric gastric JJ cord-023095-4dannjjm 2467 2 fluid fluid NN cord-023095-4dannjjm 2467 3 was be VBD cord-023095-4dannjjm 2467 4 collected collect VBN cord-023095-4dannjjm 2467 5 via via IN cord-023095-4dannjjm 2467 6 gastroscopy gastroscopy NN cord-023095-4dannjjm 2467 7 after after IN cord-023095-4dannjjm 2467 8 an an DT cord-023095-4dannjjm 2467 9 overnight overnight JJ cord-023095-4dannjjm 2467 10 fast fast RB cord-023095-4dannjjm 2467 11 for for IN cord-023095-4dannjjm 2467 12 measurement measurement NN cord-023095-4dannjjm 2467 13 of of IN cord-023095-4dannjjm 2467 14 gastric gastric JJ cord-023095-4dannjjm 2467 15 pH ph NN cord-023095-4dannjjm 2467 16 prior prior RB cord-023095-4dannjjm 2467 17 to to IN cord-023095-4dannjjm 2467 18 , , , cord-023095-4dannjjm 2467 19 during during IN cord-023095-4dannjjm 2467 20 , , , cord-023095-4dannjjm 2467 21 and and CC cord-023095-4dannjjm 2467 22 after after IN cord-023095-4dannjjm 2467 23 the the DT cord-023095-4dannjjm 2467 24 omeprazole omeprazole JJ cord-023095-4dannjjm 2467 25 treatment treatment NN cord-023095-4dannjjm 2467 26 period period NN cord-023095-4dannjjm 2467 27 . . . cord-023095-4dannjjm 2468 1 Normally normally RB cord-023095-4dannjjm 2468 2 distributed distribute VBN cord-023095-4dannjjm 2468 3 data datum NNS cord-023095-4dannjjm 2468 4 were be VBD cord-023095-4dannjjm 2468 5 compared compare VBN cord-023095-4dannjjm 2468 6 with with IN cord-023095-4dannjjm 2468 7 a a DT cord-023095-4dannjjm 2468 8 repeated repeat VBN cord-023095-4dannjjm 2468 9 measures measure NNS cord-023095-4dannjjm 2468 10 ANOVA ANOVA NNP cord-023095-4dannjjm 2468 11 and and CC cord-023095-4dannjjm 2468 12 post post VB cord-023095-4dannjjm 2468 13 hoc hoc FW cord-023095-4dannjjm 2468 14 Dunnett Dunnett NNP cord-023095-4dannjjm 2468 15 's 's POS cord-023095-4dannjjm 2468 16 test test NN cord-023095-4dannjjm 2468 17 . . . cord-023095-4dannjjm 2469 1 Data datum NNS cord-023095-4dannjjm 2469 2 that that WDT cord-023095-4dannjjm 2469 3 were be VBD cord-023095-4dannjjm 2469 4 not not RB cord-023095-4dannjjm 2469 5 normally normally RB cord-023095-4dannjjm 2469 6 distributed distribute VBN cord-023095-4dannjjm 2469 7 were be VBD cord-023095-4dannjjm 2469 8 compared compare VBN cord-023095-4dannjjm 2469 9 with with IN cord-023095-4dannjjm 2469 10 a a DT cord-023095-4dannjjm 2469 11 Friedman Friedman NNP cord-023095-4dannjjm 2469 12 's 's POS cord-023095-4dannjjm 2469 13 test test NN cord-023095-4dannjjm 2469 14 and and CC cord-023095-4dannjjm 2469 15 a a DT cord-023095-4dannjjm 2469 16 post post JJ cord-023095-4dannjjm 2469 17 - - JJ cord-023095-4dannjjm 2469 18 hoc hoc FW cord-023095-4dannjjm 2469 19 Dunn Dunn NNP cord-023095-4dannjjm 2469 20 's 's POS cord-023095-4dannjjm 2469 21 test test NN cord-023095-4dannjjm 2469 22 . . . cord-023095-4dannjjm 2470 1 Gastric gastric JJ cord-023095-4dannjjm 2470 2 fluid fluid NN cord-023095-4dannjjm 2470 3 pH ph NN cord-023095-4dannjjm 2470 4 was be VBD cord-023095-4dannjjm 2470 5 significantly significantly RB cord-023095-4dannjjm 2470 6 higher high JJR cord-023095-4dannjjm 2470 7 ( ( -LRB- cord-023095-4dannjjm 2470 8 p p NN cord-023095-4dannjjm 2470 9 o o NN cord-023095-4dannjjm 2470 10 0.01 0.01 CD cord-023095-4dannjjm 2470 11 ) ) -RRB- cord-023095-4dannjjm 2470 12 at at IN cord-023095-4dannjjm 2470 13 the the DT cord-023095-4dannjjm 2470 14 end end NN cord-023095-4dannjjm 2470 15 of of IN cord-023095-4dannjjm 2470 16 the the DT cord-023095-4dannjjm 2470 17 treatment treatment NN cord-023095-4dannjjm 2470 18 period period NN cord-023095-4dannjjm 2470 19 ( ( -LRB- cord-023095-4dannjjm 2470 20 median median NN cord-023095-4dannjjm 2470 21 : : : cord-023095-4dannjjm 2470 22 7.4 7.4 CD cord-023095-4dannjjm 2470 23 ; ; : cord-023095-4dannjjm 2470 24 range range NN cord-023095-4dannjjm 2470 25 : : : cord-023095-4dannjjm 2470 26 4.2 4.2 CD cord-023095-4dannjjm 2470 27 - - SYM cord-023095-4dannjjm 2470 28 8.1 8.1 CD cord-023095-4dannjjm 2470 29 ) ) -RRB- cord-023095-4dannjjm 2470 30 when when WRB cord-023095-4dannjjm 2470 31 compared compare VBN cord-023095-4dannjjm 2470 32 to to IN cord-023095-4dannjjm 2470 33 pretreatment pretreatment NN cord-023095-4dannjjm 2470 34 values value NNS cord-023095-4dannjjm 2470 35 ( ( -LRB- cord-023095-4dannjjm 2470 36 median median NN cord-023095-4dannjjm 2470 37 : : : cord-023095-4dannjjm 2470 38 1.7 1.7 CD cord-023095-4dannjjm 2470 39 ; ; : cord-023095-4dannjjm 2470 40 range range NN cord-023095-4dannjjm 2470 41 : : : cord-023095-4dannjjm 2470 42 1.0 1.0 CD cord-023095-4dannjjm 2470 43 - - SYM cord-023095-4dannjjm 2470 44 6.8 6.8 CD cord-023095-4dannjjm 2470 45 ) ) -RRB- cord-023095-4dannjjm 2470 46 . . . cord-023095-4dannjjm 2471 1 Serum serum NN cord-023095-4dannjjm 2471 2 gastrin gastrin NN cord-023095-4dannjjm 2471 3 concentrations concentration NNS cord-023095-4dannjjm 2471 4 increased increase VBD cord-023095-4dannjjm 2471 5 significantly significantly RB cord-023095-4dannjjm 2471 6 from from IN cord-023095-4dannjjm 2471 7 a a DT cord-023095-4dannjjm 2471 8 median median JJ cord-023095-4dannjjm 2471 9 baseline baseline NN cord-023095-4dannjjm 2471 10 of of IN cord-023095-4dannjjm 2471 11 10.0 10.0 CD cord-023095-4dannjjm 2471 12 ng ng NNP cord-023095-4dannjjm 2471 13 / / SYM cord-023095-4dannjjm 2471 14 L L NNP cord-023095-4dannjjm 2471 15 ( ( -LRB- cord-023095-4dannjjm 2471 16 range range NN cord-023095-4dannjjm 2471 17 : : : cord-023095-4dannjjm 2471 18 10.0 10.0 CD cord-023095-4dannjjm 2471 19 - - HYPH cord-023095-4dannjjm 2471 20 27.0 27.0 CD cord-023095-4dannjjm 2471 21 ) ) -RRB- cord-023095-4dannjjm 2471 22 to to IN cord-023095-4dannjjm 2471 23 a a DT cord-023095-4dannjjm 2471 24 maximum maximum JJ cord-023095-4dannjjm 2471 25 median median NN cord-023095-4dannjjm 2471 26 of of IN cord-023095-4dannjjm 2471 27 379.5 379.5 CD cord-023095-4dannjjm 2471 28 ng ng NNP cord-023095-4dannjjm 2471 29 / / SYM cord-023095-4dannjjm 2471 30 L l NN cord-023095-4dannjjm 2471 31 ( ( -LRB- cord-023095-4dannjjm 2471 32 range range NN cord-023095-4dannjjm 2471 33 : : : cord-023095-4dannjjm 2471 34 49.9 49.9 CD cord-023095-4dannjjm 2471 35 - - HYPH cord-023095-4dannjjm 2471 36 566.0 566.0 CD cord-023095-4dannjjm 2471 37 ) ) -RRB- cord-023095-4dannjjm 2471 38 at at IN cord-023095-4dannjjm 2471 39 day day NN cord-023095-4dannjjm 2471 40 9 9 CD cord-023095-4dannjjm 2471 41 of of IN cord-023095-4dannjjm 2471 42 treatment treatment NN cord-023095-4dannjjm 2471 43 ( ( -LRB- cord-023095-4dannjjm 2471 44 p p NN cord-023095-4dannjjm 2471 45 o o NN cord-023095-4dannjjm 2471 46 0.01 0.01 CD cord-023095-4dannjjm 2471 47 ) ) -RRB- cord-023095-4dannjjm 2471 48 . . . cord-023095-4dannjjm 2472 1 Serum serum NN cord-023095-4dannjjm 2472 2 gastrin gastrin NN cord-023095-4dannjjm 2472 3 remained remain VBD cord-023095-4dannjjm 2472 4 significantly significantly RB cord-023095-4dannjjm 2472 5 increased increase VBN cord-023095-4dannjjm 2472 6 above above IN cord-023095-4dannjjm 2472 7 baseline baseline JJ cord-023095-4dannjjm 2472 8 values value NNS cord-023095-4dannjjm 2472 9 from from IN cord-023095-4dannjjm 2472 10 day day NN cord-023095-4dannjjm 2472 11 6 6 CD cord-023095-4dannjjm 2472 12 to to IN cord-023095-4dannjjm 2472 13 day day NN cord-023095-4dannjjm 2472 14 15 15 CD cord-023095-4dannjjm 2472 15 of of IN cord-023095-4dannjjm 2472 16 the the DT cord-023095-4dannjjm 2472 17 treatment treatment NN cord-023095-4dannjjm 2472 18 , , , cord-023095-4dannjjm 2472 19 but but CC cord-023095-4dannjjm 2472 20 was be VBD cord-023095-4dannjjm 2472 21 not not RB cord-023095-4dannjjm 2472 22 different different JJ cord-023095-4dannjjm 2472 23 from from IN cord-023095-4dannjjm 2472 24 pre pre JJ cord-023095-4dannjjm 2472 25 - - JJ cord-023095-4dannjjm 2472 26 treatment treatment JJ cord-023095-4dannjjm 2472 27 values value NNS cord-023095-4dannjjm 2472 28 3 3 CD cord-023095-4dannjjm 2472 29 days day NNS cord-023095-4dannjjm 2472 30 after after IN cord-023095-4dannjjm 2472 31 the the DT cord-023095-4dannjjm 2472 32 end end NN cord-023095-4dannjjm 2472 33 of of IN cord-023095-4dannjjm 2472 34 the the DT cord-023095-4dannjjm 2472 35 treatment treatment NN cord-023095-4dannjjm 2472 36 . . . cord-023095-4dannjjm 2473 1 Omeprazole omeprazole NN cord-023095-4dannjjm 2473 2 treatment treatment NN cord-023095-4dannjjm 2473 3 had have VBD cord-023095-4dannjjm 2473 4 no no DT cord-023095-4dannjjm 2473 5 effect effect NN cord-023095-4dannjjm 2473 6 on on IN cord-023095-4dannjjm 2473 7 ionized ionized JJ cord-023095-4dannjjm 2473 8 calcium calcium NN cord-023095-4dannjjm 2473 9 or or CC cord-023095-4dannjjm 2473 10 PTH PTH NNP cord-023095-4dannjjm 2473 11 for for IN cord-023095-4dannjjm 2473 12 the the DT cord-023095-4dannjjm 2473 13 duration duration NN cord-023095-4dannjjm 2473 14 of of IN cord-023095-4dannjjm 2473 15 the the DT cord-023095-4dannjjm 2473 16 study study NN cord-023095-4dannjjm 2473 17 . . . cord-023095-4dannjjm 2474 1 Marginal marginal JJ cord-023095-4dannjjm 2474 2 , , , cord-023095-4dannjjm 2474 3 but but CC cord-023095-4dannjjm 2474 4 significant significant JJ cord-023095-4dannjjm 2474 5 changes change NNS cord-023095-4dannjjm 2474 6 of of IN cord-023095-4dannjjm 2474 7 25 25 CD cord-023095-4dannjjm 2474 8 OH OH NNP cord-023095-4dannjjm 2474 9 vitamin vitamin NN cord-023095-4dannjjm 2474 10 D3 D3 NNP cord-023095-4dannjjm 2474 11 were be VBD cord-023095-4dannjjm 2474 12 observed observe VBN cord-023095-4dannjjm 2474 13 at at IN cord-023095-4dannjjm 2474 14 day day NN cord-023095-4dannjjm 2474 15 15 15 CD cord-023095-4dannjjm 2474 16 ( ( -LRB- cord-023095-4dannjjm 2474 17 end end NN cord-023095-4dannjjm 2474 18 of of IN cord-023095-4dannjjm 2474 19 the the DT cord-023095-4dannjjm 2474 20 treatment treatment NN cord-023095-4dannjjm 2474 21 period period NN cord-023095-4dannjjm 2474 22 -increased -increase VBN cord-023095-4dannjjm 2474 23 by by IN cord-023095-4dannjjm 2474 24 13.8 13.8 CD cord-023095-4dannjjm 2474 25 % % NN cord-023095-4dannjjm 2474 26 ) ) -RRB- cord-023095-4dannjjm 2474 27 and and CC cord-023095-4dannjjm 2474 28 day day NN cord-023095-4dannjjm 2474 29 21 21 CD cord-023095-4dannjjm 2474 30 ( ( -LRB- cord-023095-4dannjjm 2474 31 6 6 CD cord-023095-4dannjjm 2474 32 days day NNS cord-023095-4dannjjm 2474 33 after after IN cord-023095-4dannjjm 2474 34 the the DT cord-023095-4dannjjm 2474 35 end end NN cord-023095-4dannjjm 2474 36 of of IN cord-023095-4dannjjm 2474 37 the the DT cord-023095-4dannjjm 2474 38 treatment treatment NN cord-023095-4dannjjm 2474 39 -decreased -decrease VBN cord-023095-4dannjjm 2474 40 by by IN cord-023095-4dannjjm 2474 41 14.7 14.7 CD cord-023095-4dannjjm 2474 42 % % NN cord-023095-4dannjjm 2474 43 ) ) -RRB- cord-023095-4dannjjm 2474 44 . . . cord-023095-4dannjjm 2475 1 This this DT cord-023095-4dannjjm 2475 2 study study NN cord-023095-4dannjjm 2475 3 shows show VBZ cord-023095-4dannjjm 2475 4 that that DT cord-023095-4dannjjm 2475 5 treatment treatment NN cord-023095-4dannjjm 2475 6 with with IN cord-023095-4dannjjm 2475 7 omeprazole omeprazole NN cord-023095-4dannjjm 2475 8 for for IN cord-023095-4dannjjm 2475 9 2 2 CD cord-023095-4dannjjm 2475 10 weeks week NNS cord-023095-4dannjjm 2475 11 results result NNS cord-023095-4dannjjm 2475 12 in in IN cord-023095-4dannjjm 2475 13 a a DT cord-023095-4dannjjm 2475 14 profound profound JJ cord-023095-4dannjjm 2475 15 and and CC cord-023095-4dannjjm 2475 16 sustained sustained JJ cord-023095-4dannjjm 2475 17 increase increase NN cord-023095-4dannjjm 2475 18 in in IN cord-023095-4dannjjm 2475 19 serum serum NN cord-023095-4dannjjm 2475 20 gastrin gastrin NN cord-023095-4dannjjm 2475 21 concentration concentration NN cord-023095-4dannjjm 2475 22 in in IN cord-023095-4dannjjm 2475 23 dogs dog NNS cord-023095-4dannjjm 2475 24 . . . cord-023095-4dannjjm 2476 1 This this DT cord-023095-4dannjjm 2476 2 effect effect NN cord-023095-4dannjjm 2476 3 is be VBZ cord-023095-4dannjjm 2476 4 rapidly rapidly RB cord-023095-4dannjjm 2476 5 reversible reversible JJ cord-023095-4dannjjm 2476 6 after after IN cord-023095-4dannjjm 2476 7 cessation cessation NN cord-023095-4dannjjm 2476 8 of of IN cord-023095-4dannjjm 2476 9 the the DT cord-023095-4dannjjm 2476 10 treatment treatment NN cord-023095-4dannjjm 2476 11 . . . cord-023095-4dannjjm 2477 1 No no DT cord-023095-4dannjjm 2477 2 effect effect NN cord-023095-4dannjjm 2477 3 on on IN cord-023095-4dannjjm 2477 4 calcium calcium NN cord-023095-4dannjjm 2477 5 metabolism metabolism NN cord-023095-4dannjjm 2477 6 was be VBD cord-023095-4dannjjm 2477 7 observed observe VBN cord-023095-4dannjjm 2477 8 . . . cord-023095-4dannjjm 2478 1 However however RB cord-023095-4dannjjm 2478 2 , , , cord-023095-4dannjjm 2478 3 this this DT cord-023095-4dannjjm 2478 4 study study NN cord-023095-4dannjjm 2478 5 documents document VBZ cord-023095-4dannjjm 2478 6 only only RB cord-023095-4dannjjm 2478 7 the the DT cord-023095-4dannjjm 2478 8 effect effect NN cord-023095-4dannjjm 2478 9 of of IN cord-023095-4dannjjm 2478 10 short short JJ cord-023095-4dannjjm 2478 11 - - HYPH cord-023095-4dannjjm 2478 12 term term NN cord-023095-4dannjjm 2478 13 treatment treatment NN cord-023095-4dannjjm 2478 14 and and CC cord-023095-4dannjjm 2478 15 it -PRON- PRP cord-023095-4dannjjm 2478 16 is be VBZ cord-023095-4dannjjm 2478 17 possible possible JJ cord-023095-4dannjjm 2478 18 that that IN cord-023095-4dannjjm 2478 19 the the DT cord-023095-4dannjjm 2478 20 effects effect NNS cord-023095-4dannjjm 2478 21 of of IN cord-023095-4dannjjm 2478 22 long long JJ cord-023095-4dannjjm 2478 23 - - HYPH cord-023095-4dannjjm 2478 24 term term NN cord-023095-4dannjjm 2478 25 administration administration NN cord-023095-4dannjjm 2478 26 are be VBP cord-023095-4dannjjm 2478 27 different different JJ cord-023095-4dannjjm 2478 28 . . . cord-023095-4dannjjm 2479 1 Omeprazole omeprazole NN cord-023095-4dannjjm 2479 2 treatment treatment NN cord-023095-4dannjjm 2479 3 has have VBZ cord-023095-4dannjjm 2479 4 been be VBN cord-023095-4dannjjm 2479 5 associated associate VBN cord-023095-4dannjjm 2479 6 with with IN cord-023095-4dannjjm 2479 7 small small JJ cord-023095-4dannjjm 2479 8 intestinal intestinal JJ cord-023095-4dannjjm 2479 9 bacterial bacterial JJ cord-023095-4dannjjm 2479 10 overgrowth overgrowth NN cord-023095-4dannjjm 2479 11 and and CC cord-023095-4dannjjm 2479 12 a a DT cord-023095-4dannjjm 2479 13 higher high JJR cord-023095-4dannjjm 2479 14 risk risk NN cord-023095-4dannjjm 2479 15 for for IN cord-023095-4dannjjm 2479 16 infectious infectious JJ cord-023095-4dannjjm 2479 17 enteropathies enteropathy NNS cord-023095-4dannjjm 2479 18 in in IN cord-023095-4dannjjm 2479 19 humans human NNS cord-023095-4dannjjm 2479 20 . . . cord-023095-4dannjjm 2480 1 Using use VBG cord-023095-4dannjjm 2480 2 a a DT cord-023095-4dannjjm 2480 3 semi semi JJ cord-023095-4dannjjm 2480 4 - - JJ cord-023095-4dannjjm 2480 5 quantitative quantitative JJ cord-023095-4dannjjm 2480 6 sequencing sequencing NN cord-023095-4dannjjm 2480 7 approach approach NN cord-023095-4dannjjm 2480 8 , , , cord-023095-4dannjjm 2480 9 we -PRON- PRP cord-023095-4dannjjm 2480 10 have have VBP cord-023095-4dannjjm 2480 11 previously previously RB cord-023095-4dannjjm 2480 12 shown show VBN cord-023095-4dannjjm 2480 13 that that IN cord-023095-4dannjjm 2480 14 omeprazole omeprazole JJ cord-023095-4dannjjm 2480 15 treatment treatment NN cord-023095-4dannjjm 2480 16 may may MD cord-023095-4dannjjm 2480 17 lead lead VB cord-023095-4dannjjm 2480 18 to to IN cord-023095-4dannjjm 2480 19 alterations alteration NNS cord-023095-4dannjjm 2480 20 in in IN cord-023095-4dannjjm 2480 21 both both DT cord-023095-4dannjjm 2480 22 duodenal duodenal JJ cord-023095-4dannjjm 2480 23 and and CC cord-023095-4dannjjm 2480 24 gastric gastric JJ cord-023095-4dannjjm 2480 25 bacterial bacterial JJ cord-023095-4dannjjm 2480 26 populations population NNS cord-023095-4dannjjm 2480 27 in in IN cord-023095-4dannjjm 2480 28 healthy healthy JJ cord-023095-4dannjjm 2480 29 dogs dog NNS cord-023095-4dannjjm 2480 30 ( ( -LRB- cord-023095-4dannjjm 2480 31 ACVIM ACVIM NNP cord-023095-4dannjjm 2480 32 2010 2010 CD cord-023095-4dannjjm 2480 33 ) ) -RRB- cord-023095-4dannjjm 2480 34 . . . cord-023095-4dannjjm 2481 1 However however RB cord-023095-4dannjjm 2481 2 , , , cord-023095-4dannjjm 2481 3 a a DT cord-023095-4dannjjm 2481 4 sequencing sequencing NN cord-023095-4dannjjm 2481 5 approach approach NN cord-023095-4dannjjm 2481 6 can can MD cord-023095-4dannjjm 2481 7 only only RB cord-023095-4dannjjm 2481 8 estimate estimate VB cord-023095-4dannjjm 2481 9 relative relative JJ cord-023095-4dannjjm 2481 10 proportions proportion NNS cord-023095-4dannjjm 2481 11 of of IN cord-023095-4dannjjm 2481 12 genomic genomic JJ cord-023095-4dannjjm 2481 13 bacterial bacterial JJ cord-023095-4dannjjm 2481 14 targets target NNS cord-023095-4dannjjm 2481 15 . . . cord-023095-4dannjjm 2482 1 Therefore therefore RB cord-023095-4dannjjm 2482 2 , , , cord-023095-4dannjjm 2482 3 significant significant JJ cord-023095-4dannjjm 2482 4 changes change NNS cord-023095-4dannjjm 2482 5 in in IN cord-023095-4dannjjm 2482 6 the the DT cord-023095-4dannjjm 2482 7 total total JJ cord-023095-4dannjjm 2482 8 number number NN cord-023095-4dannjjm 2482 9 of of IN cord-023095-4dannjjm 2482 10 bacteria bacteria NNS cord-023095-4dannjjm 2482 11 could could MD cord-023095-4dannjjm 2482 12 not not RB cord-023095-4dannjjm 2482 13 be be VB cord-023095-4dannjjm 2482 14 evaluated evaluate VBN cord-023095-4dannjjm 2482 15 . . . cord-023095-4dannjjm 2483 1 The the DT cord-023095-4dannjjm 2483 2 aim aim NN cord-023095-4dannjjm 2483 3 of of IN cord-023095-4dannjjm 2483 4 this this DT cord-023095-4dannjjm 2483 5 study study NN cord-023095-4dannjjm 2483 6 was be VBD cord-023095-4dannjjm 2483 7 to to TO cord-023095-4dannjjm 2483 8 quantify quantify VB cord-023095-4dannjjm 2483 9 gastric gastric JJ cord-023095-4dannjjm 2483 10 and and CC cord-023095-4dannjjm 2483 11 duodenal duodenal JJ cord-023095-4dannjjm 2483 12 bacterial bacterial JJ cord-023095-4dannjjm 2483 13 populations population NNS cord-023095-4dannjjm 2483 14 in in IN cord-023095-4dannjjm 2483 15 dogs dog NNS cord-023095-4dannjjm 2483 16 undergoing undergo VBG cord-023095-4dannjjm 2483 17 omeprazole omeprazole NN cord-023095-4dannjjm 2483 18 treatment treatment NN cord-023095-4dannjjm 2483 19 . . . cord-023095-4dannjjm 2484 1 Eight eight CD cord-023095-4dannjjm 2484 2 9 9 CD cord-023095-4dannjjm 2484 3 month month NN cord-023095-4dannjjm 2484 4 - - HYPH cord-023095-4dannjjm 2484 5 old old JJ cord-023095-4dannjjm 2484 6 healthy healthy JJ cord-023095-4dannjjm 2484 7 research research NN cord-023095-4dannjjm 2484 8 dogs dog NNS cord-023095-4dannjjm 2484 9 ( ( -LRB- cord-023095-4dannjjm 2484 10 4 4 CD cord-023095-4dannjjm 2484 11 males male NNS cord-023095-4dannjjm 2484 12 and and CC cord-023095-4dannjjm 2484 13 4 4 CD cord-023095-4dannjjm 2484 14 females female NNS cord-023095-4dannjjm 2484 15 ) ) -RRB- cord-023095-4dannjjm 2484 16 were be VBD cord-023095-4dannjjm 2484 17 enrolled enrol VBN cord-023095-4dannjjm 2484 18 . . . cord-023095-4dannjjm 2485 1 The the DT cord-023095-4dannjjm 2485 2 dogs dog NNS cord-023095-4dannjjm 2485 3 received receive VBD cord-023095-4dannjjm 2485 4 an an DT cord-023095-4dannjjm 2485 5 average average JJ cord-023095-4dannjjm 2485 6 dose dose NN cord-023095-4dannjjm 2485 7 of of IN cord-023095-4dannjjm 2485 8 1.1 1.1 CD cord-023095-4dannjjm 2485 9 mg mg NNP cord-023095-4dannjjm 2485 10 / / SYM cord-023095-4dannjjm 2485 11 kg kg NNP cord-023095-4dannjjm 2485 12 of of IN cord-023095-4dannjjm 2485 13 omeprazole omeprazole NN cord-023095-4dannjjm 2485 14 orally orally RB cord-023095-4dannjjm 2485 15 twice twice PDT cord-023095-4dannjjm 2485 16 a a DT cord-023095-4dannjjm 2485 17 day day NN cord-023095-4dannjjm 2485 18 for for IN cord-023095-4dannjjm 2485 19 15 15 CD cord-023095-4dannjjm 2485 20 days day NNS cord-023095-4dannjjm 2485 21 . . . cord-023095-4dannjjm 2486 1 Endoscopic Endoscopic NNS cord-023095-4dannjjm 2486 2 gastric gastric JJ cord-023095-4dannjjm 2486 3 and and CC cord-023095-4dannjjm 2486 4 duodenal duodenal JJ cord-023095-4dannjjm 2486 5 biopsies biopsy NNS cord-023095-4dannjjm 2486 6 were be VBD cord-023095-4dannjjm 2486 7 harvested harvest VBN cord-023095-4dannjjm 2486 8 30 30 CD cord-023095-4dannjjm 2486 9 and and CC cord-023095-4dannjjm 2486 10 15 15 CD cord-023095-4dannjjm 2486 11 days day NNS cord-023095-4dannjjm 2486 12 before before IN cord-023095-4dannjjm 2486 13 starting start VBG cord-023095-4dannjjm 2486 14 omeprazole omeprazole JJ cord-023095-4dannjjm 2486 15 treatment treatment NN cord-023095-4dannjjm 2486 16 , , , cord-023095-4dannjjm 2486 17 on on IN cord-023095-4dannjjm 2486 18 the the DT cord-023095-4dannjjm 2486 19 last last JJ cord-023095-4dannjjm 2486 20 day day NN cord-023095-4dannjjm 2486 21 of of IN cord-023095-4dannjjm 2486 22 treatment treatment NN cord-023095-4dannjjm 2486 23 ( ( -LRB- cord-023095-4dannjjm 2486 24 day day NN cord-023095-4dannjjm 2486 25 15 15 CD cord-023095-4dannjjm 2486 26 ) ) -RRB- cord-023095-4dannjjm 2486 27 , , , cord-023095-4dannjjm 2486 28 and and CC cord-023095-4dannjjm 2486 29 15 15 CD cord-023095-4dannjjm 2486 30 days day NNS cord-023095-4dannjjm 2486 31 after after IN cord-023095-4dannjjm 2486 32 the the DT cord-023095-4dannjjm 2486 33 end end NN cord-023095-4dannjjm 2486 34 of of IN cord-023095-4dannjjm 2486 35 treatment treatment NN cord-023095-4dannjjm 2486 36 ( ( -LRB- cord-023095-4dannjjm 2486 37 day day NN cord-023095-4dannjjm 2486 38 30 30 CD cord-023095-4dannjjm 2486 39 ) ) -RRB- cord-023095-4dannjjm 2486 40 . . . cord-023095-4dannjjm 2487 1 All all DT cord-023095-4dannjjm 2487 2 biopsies biopsy NNS cord-023095-4dannjjm 2487 3 were be VBD cord-023095-4dannjjm 2487 4 fixed fix VBN cord-023095-4dannjjm 2487 5 in in IN cord-023095-4dannjjm 2487 6 10 10 CD cord-023095-4dannjjm 2487 7 % % NN cord-023095-4dannjjm 2487 8 formalin formalin NN cord-023095-4dannjjm 2487 9 for for IN cord-023095-4dannjjm 2487 10 24 24 CD cord-023095-4dannjjm 2487 11 hours hour NNS cord-023095-4dannjjm 2487 12 , , , cord-023095-4dannjjm 2487 13 processed process VBN cord-023095-4dannjjm 2487 14 , , , cord-023095-4dannjjm 2487 15 and and CC cord-023095-4dannjjm 2487 16 embedded embed VBN cord-023095-4dannjjm 2487 17 in in IN cord-023095-4dannjjm 2487 18 paraffin paraffin NN cord-023095-4dannjjm 2487 19 blocks block NNS cord-023095-4dannjjm 2487 20 . . . cord-023095-4dannjjm 2488 1 Fluorescent fluorescent JJ cord-023095-4dannjjm 2488 2 in in IN cord-023095-4dannjjm 2488 3 situ situ NN cord-023095-4dannjjm 2488 4 hybridization hybridization NN cord-023095-4dannjjm 2488 5 was be VBD cord-023095-4dannjjm 2488 6 used use VBN cord-023095-4dannjjm 2488 7 to to TO cord-023095-4dannjjm 2488 8 quantify quantify VB cord-023095-4dannjjm 2488 9 mucosa mucosa JJ cord-023095-4dannjjm 2488 10 - - HYPH cord-023095-4dannjjm 2488 11 associated associate VBN cord-023095-4dannjjm 2488 12 bacteria bacteria NNS cord-023095-4dannjjm 2488 13 using use VBG cord-023095-4dannjjm 2488 14 fluorescently fluorescently RB cord-023095-4dannjjm 2488 15 - - HYPH cord-023095-4dannjjm 2488 16 labeled label VBN cord-023095-4dannjjm 2488 17 probes probe NNS cord-023095-4dannjjm 2488 18 targeting target VBG cord-023095-4dannjjm 2488 19 the the DT cord-023095-4dannjjm 2488 20 16S 16S NNP cord-023095-4dannjjm 2488 21 ribosomal ribosomal NN cord-023095-4dannjjm 2488 22 RNA RNA NNP cord-023095-4dannjjm 2488 23 . . . cord-023095-4dannjjm 2489 1 Statistical statistical JJ cord-023095-4dannjjm 2489 2 analysis analysis NN cord-023095-4dannjjm 2489 3 aimed aim VBN cord-023095-4dannjjm 2489 4 to to TO cord-023095-4dannjjm 2489 5 compare compare VB cord-023095-4dannjjm 2489 6 changes change NNS cord-023095-4dannjjm 2489 7 in in IN cord-023095-4dannjjm 2489 8 Helicobacter Helicobacter NNP cord-023095-4dannjjm 2489 9 spp spp NNS cord-023095-4dannjjm 2489 10 . . . cord-023095-4dannjjm 2490 1 in in IN cord-023095-4dannjjm 2490 2 gastric gastric JJ cord-023095-4dannjjm 2490 3 biopsies biopsy NNS cord-023095-4dannjjm 2490 4 and and CC cord-023095-4dannjjm 2490 5 total total JJ cord-023095-4dannjjm 2490 6 bacteria bacteria NNS cord-023095-4dannjjm 2490 7 in in IN cord-023095-4dannjjm 2490 8 both both CC cord-023095-4dannjjm 2490 9 gastric gastric JJ cord-023095-4dannjjm 2490 10 and and CC cord-023095-4dannjjm 2490 11 duodenal duodenal JJ cord-023095-4dannjjm 2490 12 biopsies biopsy NNS cord-023095-4dannjjm 2490 13 using use VBG cord-023095-4dannjjm 2490 14 the the DT cord-023095-4dannjjm 2490 15 GLIMMIX GLIMMIX NNP cord-023095-4dannjjm 2490 16 and and CC cord-023095-4dannjjm 2490 17 NPAR1WAY npar1way CD cord-023095-4dannjjm 2490 18 procedures procedure NNS cord-023095-4dannjjm 2490 19 in in IN cord-023095-4dannjjm 2490 20 SAS SAS NNP cord-023095-4dannjjm 2490 21 s s POS cord-023095-4dannjjm 2490 22 9.2 9.2 CD cord-023095-4dannjjm 2490 23 . . . cord-023095-4dannjjm 2491 1 Bacteria Bacteria NNS cord-023095-4dannjjm 2491 2 were be VBD cord-023095-4dannjjm 2491 3 counted count VBN cord-023095-4dannjjm 2491 4 in in IN cord-023095-4dannjjm 2491 5 1,174 1,174 CD cord-023095-4dannjjm 2491 6 and and CC cord-023095-4dannjjm 2491 7 989 989 CD cord-023095-4dannjjm 2491 8 microscopic microscopic JJ cord-023095-4dannjjm 2491 9 fields field NNS cord-023095-4dannjjm 2491 10 ( ( -LRB- cord-023095-4dannjjm 2491 11 63Â 63Â NNP cord-023095-4dannjjm 2491 12 ) ) -RRB- cord-023095-4dannjjm 2491 13 obtained obtain VBN cord-023095-4dannjjm 2491 14 from from IN cord-023095-4dannjjm 2491 15 155 155 CD cord-023095-4dannjjm 2491 16 and and CC cord-023095-4dannjjm 2491 17 132 132 CD cord-023095-4dannjjm 2491 18 gastric gastric JJ cord-023095-4dannjjm 2491 19 and and CC cord-023095-4dannjjm 2491 20 duodenal duodenal JJ cord-023095-4dannjjm 2491 21 biopsies biopsy NNS cord-023095-4dannjjm 2491 22 , , , cord-023095-4dannjjm 2491 23 respectively respectively RB cord-023095-4dannjjm 2491 24 . . . cord-023095-4dannjjm 2492 1 In in IN cord-023095-4dannjjm 2492 2 the the DT cord-023095-4dannjjm 2492 3 stomach stomach NN cord-023095-4dannjjm 2492 4 , , , cord-023095-4dannjjm 2492 5 omeprazole omeprazole NN cord-023095-4dannjjm 2492 6 treatment treatment NN cord-023095-4dannjjm 2492 7 led lead VBD cord-023095-4dannjjm 2492 8 to to IN cord-023095-4dannjjm 2492 9 a a DT cord-023095-4dannjjm 2492 10 decrease decrease NN cord-023095-4dannjjm 2492 11 in in IN cord-023095-4dannjjm 2492 12 Helicobacter Helicobacter NNP cord-023095-4dannjjm 2492 13 spp spp NNS cord-023095-4dannjjm 2492 14 . . . cord-023095-4dannjjm 2493 1 ( ( -LRB- cord-023095-4dannjjm 2493 2 log log NN cord-023095-4dannjjm 2493 3 of of IN cord-023095-4dannjjm 2493 4 average average JJ cord-023095-4dannjjm 2493 5 counts count NNS cord-023095-4dannjjm 2493 6 AE AE NNP cord-023095-4dannjjm 2493 7 standard standard JJ cord-023095-4dannjjm 2493 8 error error NN cord-023095-4dannjjm 2493 9 : : : cord-023095-4dannjjm 2493 10 1.98 1.98 CD cord-023095-4dannjjm 2493 11 AE AE NNP cord-023095-4dannjjm 2493 12 0.14 0.14 CD cord-023095-4dannjjm 2493 13 at at IN cord-023095-4dannjjm 2493 14 day day NN cord-023095-4dannjjm 2493 15 15 15 CD cord-023095-4dannjjm 2493 16 ) ) -RRB- cord-023095-4dannjjm 2493 17 when when WRB cord-023095-4dannjjm 2493 18 compared compare VBN cord-023095-4dannjjm 2493 19 to to IN cord-023095-4dannjjm 2493 20 the the DT cord-023095-4dannjjm 2493 21 counts count NNS cord-023095-4dannjjm 2493 22 30 30 CD cord-023095-4dannjjm 2493 23 ( ( -LRB- cord-023095-4dannjjm 2493 24 2.43 2.43 CD cord-023095-4dannjjm 2493 25 AE AE NNP cord-023095-4dannjjm 2493 26 0.13 0.13 CD cord-023095-4dannjjm 2493 27 , , , cord-023095-4dannjjm 2493 28 p0.0001 p0.0001 CD cord-023095-4dannjjm 2493 29 ) ) -RRB- cord-023095-4dannjjm 2493 30 and and CC cord-023095-4dannjjm 2493 31 15 15 CD cord-023095-4dannjjm 2493 32 ( ( -LRB- cord-023095-4dannjjm 2493 33 2.40 2.40 CD cord-023095-4dannjjm 2493 34 AE AE NNP cord-023095-4dannjjm 2493 35 0.13 0.13 CD cord-023095-4dannjjm 2493 36 , , , cord-023095-4dannjjm 2493 37 p0.0001 p0.0001 CD cord-023095-4dannjjm 2493 38 ) ) -RRB- cord-023095-4dannjjm 2493 39 days day NNS cord-023095-4dannjjm 2493 40 before before IN cord-023095-4dannjjm 2493 41 treatment treatment NN cord-023095-4dannjjm 2493 42 . . . cord-023095-4dannjjm 2494 1 After after IN cord-023095-4dannjjm 2494 2 completion completion NN cord-023095-4dannjjm 2494 3 of of IN cord-023095-4dannjjm 2494 4 omeprazole omeprazole NN cord-023095-4dannjjm 2494 5 treatment treatment NN cord-023095-4dannjjm 2494 6 , , , cord-023095-4dannjjm 2494 7 Helicobacter Helicobacter NNP cord-023095-4dannjjm 2494 8 spp spp NNS cord-023095-4dannjjm 2494 9 . . . cord-023095-4dannjjm 2495 1 increased increase VBN cord-023095-4dannjjm 2495 2 and and CC cord-023095-4dannjjm 2495 3 returned return VBD cord-023095-4dannjjm 2495 4 to to IN cord-023095-4dannjjm 2495 5 baseline baseline JJ cord-023095-4dannjjm 2495 6 counts count NNS cord-023095-4dannjjm 2495 7 ( ( -LRB- cord-023095-4dannjjm 2495 8 2.45 2.45 CD cord-023095-4dannjjm 2495 9 AE AE NNP cord-023095-4dannjjm 2495 10 0.13 0.13 CD cord-023095-4dannjjm 2495 11 at at IN cord-023095-4dannjjm 2495 12 day day NN cord-023095-4dannjjm 2495 13 30 30 CD cord-023095-4dannjjm 2495 14 , , , cord-023095-4dannjjm 2495 15 p0.0001 p0.0001 CD cord-023095-4dannjjm 2495 16 vs vs IN cord-023095-4dannjjm 2495 17 day day NN cord-023095-4dannjjm 2495 18 15 15 CD cord-023095-4dannjjm 2495 19 ) ) -RRB- cord-023095-4dannjjm 2495 20 . . . cord-023095-4dannjjm 2496 1 Also also RB cord-023095-4dannjjm 2496 2 , , , cord-023095-4dannjjm 2496 3 in in IN cord-023095-4dannjjm 2496 4 the the DT cord-023095-4dannjjm 2496 5 stomach stomach NN cord-023095-4dannjjm 2496 6 , , , cord-023095-4dannjjm 2496 7 non non JJ cord-023095-4dannjjm 2496 8 - - JJ cord-023095-4dannjjm 2496 9 Helicobacter helicobacter JJ cord-023095-4dannjjm 2496 10 spp spp NNS cord-023095-4dannjjm 2496 11 . . . cord-023095-4dannjjm 2497 1 bacteria bacteria NNS cord-023095-4dannjjm 2497 2 were be VBD cord-023095-4dannjjm 2497 3 observed observe VBN cord-023095-4dannjjm 2497 4 more more RBR cord-023095-4dannjjm 2497 5 often often RB cord-023095-4dannjjm 2497 6 during during IN cord-023095-4dannjjm 2497 7 omeprazole omeprazole JJ cord-023095-4dannjjm 2497 8 treatment treatment NN cord-023095-4dannjjm 2497 9 ( ( -LRB- cord-023095-4dannjjm 2497 10 median median NN cord-023095-4dannjjm 2497 11 : : : cord-023095-4dannjjm 2497 12 3 3 CD cord-023095-4dannjjm 2497 13 , , , cord-023095-4dannjjm 2497 14 range range NN cord-023095-4dannjjm 2497 15 : : : cord-023095-4dannjjm 2497 16 0 0 CD cord-023095-4dannjjm 2497 17 - - SYM cord-023095-4dannjjm 2497 18 20 20 CD cord-023095-4dannjjm 2497 19 ) ) -RRB- cord-023095-4dannjjm 2497 20 than than IN cord-023095-4dannjjm 2497 21 on on IN cord-023095-4dannjjm 2497 22 days day NNS cord-023095-4dannjjm 2497 23 30 30 CD cord-023095-4dannjjm 2497 24 ( ( -LRB- cord-023095-4dannjjm 2497 25 median median NN cord-023095-4dannjjm 2497 26 : : SYM cord-023095-4dannjjm 2497 27 0 0 CD cord-023095-4dannjjm 2497 28 , , , cord-023095-4dannjjm 2497 29 range range NN cord-023095-4dannjjm 2497 30 : : : cord-023095-4dannjjm 2497 31 0 0 CD cord-023095-4dannjjm 2497 32 - - SYM cord-023095-4dannjjm 2497 33 3 3 CD cord-023095-4dannjjm 2497 34 ) ) -RRB- cord-023095-4dannjjm 2497 35 and and CC cord-023095-4dannjjm 2497 36 15 15 CD cord-023095-4dannjjm 2497 37 ( ( -LRB- cord-023095-4dannjjm 2497 38 median median NN cord-023095-4dannjjm 2497 39 : : SYM cord-023095-4dannjjm 2497 40 1 1 CD cord-023095-4dannjjm 2497 41 , , , cord-023095-4dannjjm 2497 42 range range NN cord-023095-4dannjjm 2497 43 : : : cord-023095-4dannjjm 2497 44 0 0 CD cord-023095-4dannjjm 2497 45 - - SYM cord-023095-4dannjjm 2497 46 6 6 CD cord-023095-4dannjjm 2497 47 ) ) -RRB- cord-023095-4dannjjm 2497 48 before before IN cord-023095-4dannjjm 2497 49 and and CC cord-023095-4dannjjm 2497 50 15 15 CD cord-023095-4dannjjm 2497 51 days day NNS cord-023095-4dannjjm 2497 52 after after IN cord-023095-4dannjjm 2497 53 ( ( -LRB- cord-023095-4dannjjm 2497 54 median median NN cord-023095-4dannjjm 2497 55 : : SYM cord-023095-4dannjjm 2497 56 0 0 CD cord-023095-4dannjjm 2497 57 , , , cord-023095-4dannjjm 2497 58 range range NN cord-023095-4dannjjm 2497 59 : : : cord-023095-4dannjjm 2497 60 0 0 CD cord-023095-4dannjjm 2497 61 - - SYM cord-023095-4dannjjm 2497 62 2 2 CD cord-023095-4dannjjm 2497 63 ) ) -RRB- cord-023095-4dannjjm 2498 1 omeprazole omeprazole NN cord-023095-4dannjjm 2498 2 treatment treatment NN cord-023095-4dannjjm 2498 3 ; ; : cord-023095-4dannjjm 2498 4 however however RB cord-023095-4dannjjm 2498 5 , , , cord-023095-4dannjjm 2498 6 statistical statistical JJ cord-023095-4dannjjm 2498 7 comparison comparison NN cord-023095-4dannjjm 2498 8 across across IN cord-023095-4dannjjm 2498 9 time time NN cord-023095-4dannjjm 2498 10 points point NNS cord-023095-4dannjjm 2498 11 did do VBD cord-023095-4dannjjm 2498 12 not not RB cord-023095-4dannjjm 2498 13 reach reach VB cord-023095-4dannjjm 2498 14 significance significance NN cord-023095-4dannjjm 2498 15 . . . cord-023095-4dannjjm 2499 1 In in IN cord-023095-4dannjjm 2499 2 the the DT cord-023095-4dannjjm 2499 3 duodenum duodenum NN cord-023095-4dannjjm 2499 4 , , , cord-023095-4dannjjm 2499 5 while while IN cord-023095-4dannjjm 2499 6 the the DT cord-023095-4dannjjm 2499 7 median median JJ cord-023095-4dannjjm 2499 8 number number NN cord-023095-4dannjjm 2499 9 of of IN cord-023095-4dannjjm 2499 10 bacteria bacteria NNS cord-023095-4dannjjm 2499 11 for for IN cord-023095-4dannjjm 2499 12 all all DT cord-023095-4dannjjm 2499 13 time time NN cord-023095-4dannjjm 2499 14 points point NNS cord-023095-4dannjjm 2499 15 was be VBD cord-023095-4dannjjm 2499 16 zero zero CD cord-023095-4dannjjm 2499 17 , , , cord-023095-4dannjjm 2499 18 non non JJ cord-023095-4dannjjm 2499 19 - - JJ cord-023095-4dannjjm 2499 20 parametric parametric JJ cord-023095-4dannjjm 2499 21 comparison comparison NN cord-023095-4dannjjm 2499 22 of of IN cord-023095-4dannjjm 2499 23 median median JJ cord-023095-4dannjjm 2499 24 scores score NNS cord-023095-4dannjjm 2499 25 ( ( -LRB- cord-023095-4dannjjm 2499 26 number number NN cord-023095-4dannjjm 2499 27 of of IN cord-023095-4dannjjm 2499 28 points point NNS cord-023095-4dannjjm 2499 29 above above IN cord-023095-4dannjjm 2499 30 median median NN cord-023095-4dannjjm 2499 31 ) ) -RRB- cord-023095-4dannjjm 2499 32 revealed reveal VBD cord-023095-4dannjjm 2499 33 significantly significantly RB cord-023095-4dannjjm 2499 34 higher high JJR cord-023095-4dannjjm 2499 35 numbers number NNS cord-023095-4dannjjm 2499 36 of of IN cord-023095-4dannjjm 2499 37 bacteria bacteria NNS cord-023095-4dannjjm 2499 38 during during IN cord-023095-4dannjjm 2499 39 omeprazole omeprazole JJ cord-023095-4dannjjm 2499 40 treatment treatment NN cord-023095-4dannjjm 2499 41 ( ( -LRB- cord-023095-4dannjjm 2499 42 p p NN cord-023095-4dannjjm 2499 43 5 5 CD cord-023095-4dannjjm 2499 44 0.0063 0.0063 CD cord-023095-4dannjjm 2499 45 ) ) -RRB- cord-023095-4dannjjm 2499 46 . . . cord-023095-4dannjjm 2500 1 Our -PRON- PRP$ cord-023095-4dannjjm 2500 2 results result NNS cord-023095-4dannjjm 2500 3 suggest suggest VBP cord-023095-4dannjjm 2500 4 that that IN cord-023095-4dannjjm 2500 5 omeprazole omeprazole JJ cord-023095-4dannjjm 2500 6 treatment treatment NN cord-023095-4dannjjm 2500 7 for for IN cord-023095-4dannjjm 2500 8 2 2 CD cord-023095-4dannjjm 2500 9 weeks week NNS cord-023095-4dannjjm 2500 10 leads lead VBZ cord-023095-4dannjjm 2500 11 to to IN cord-023095-4dannjjm 2500 12 a a DT cord-023095-4dannjjm 2500 13 lower low JJR cord-023095-4dannjjm 2500 14 abundance abundance NN cord-023095-4dannjjm 2500 15 of of IN cord-023095-4dannjjm 2500 16 Helicobacter Helicobacter NNP cord-023095-4dannjjm 2500 17 spp spp NNS cord-023095-4dannjjm 2500 18 . . . cord-023095-4dannjjm 2501 1 organisms organism NNS cord-023095-4dannjjm 2501 2 in in IN cord-023095-4dannjjm 2501 3 the the DT cord-023095-4dannjjm 2501 4 stomach stomach NN cord-023095-4dannjjm 2501 5 of of IN cord-023095-4dannjjm 2501 6 healthy healthy JJ cord-023095-4dannjjm 2501 7 dogs dog NNS cord-023095-4dannjjm 2501 8 . . . cord-023095-4dannjjm 2502 1 Also also RB cord-023095-4dannjjm 2502 2 , , , cord-023095-4dannjjm 2502 3 this this DT cord-023095-4dannjjm 2502 4 transient transient JJ cord-023095-4dannjjm 2502 5 decrease decrease NN cord-023095-4dannjjm 2502 6 in in IN cord-023095-4dannjjm 2502 7 Helicobacter Helicobacter NNP cord-023095-4dannjjm 2502 8 spp spp NNS cord-023095-4dannjjm 2502 9 . . . cord-023095-4dannjjm 2502 10 was be VBD cord-023095-4dannjjm 2502 11 accompanied accompany VBN cord-023095-4dannjjm 2502 12 by by IN cord-023095-4dannjjm 2502 13 a a DT cord-023095-4dannjjm 2502 14 higher high JJR cord-023095-4dannjjm 2502 15 abundance abundance NN cord-023095-4dannjjm 2502 16 of of IN cord-023095-4dannjjm 2502 17 other other JJ cord-023095-4dannjjm 2502 18 bacteria bacteria NNS cord-023095-4dannjjm 2502 19 in in IN cord-023095-4dannjjm 2502 20 both both CC cord-023095-4dannjjm 2502 21 the the DT cord-023095-4dannjjm 2502 22 stomach stomach NN cord-023095-4dannjjm 2502 23 and and CC cord-023095-4dannjjm 2502 24 the the DT cord-023095-4dannjjm 2502 25 proximal proximal JJ cord-023095-4dannjjm 2502 26 duodenum duodenum NN cord-023095-4dannjjm 2502 27 . . . cord-023095-4dannjjm 2503 1 The the DT cord-023095-4dannjjm 2503 2 SmartPill SmartPill NNP cord-023095-4dannjjm 2503 3 pH.P pH.P NNP cord-023095-4dannjjm 2503 4 s s POS cord-023095-4dannjjm 2503 5 capsule capsule NN cord-023095-4dannjjm 2503 6 ( ( -LRB- cord-023095-4dannjjm 2503 7 The the DT cord-023095-4dannjjm 2503 8 SmartPill SmartPill NNP cord-023095-4dannjjm 2503 9 Corporation Corporation NNP cord-023095-4dannjjm 2503 10 ) ) -RRB- cord-023095-4dannjjm 2503 11 is be VBZ cord-023095-4dannjjm 2503 12 a a DT cord-023095-4dannjjm 2503 13 wireless wireless JJ cord-023095-4dannjjm 2503 14 motility motility NN cord-023095-4dannjjm 2503 15 capsule capsule NN cord-023095-4dannjjm 2503 16 that that WDT cord-023095-4dannjjm 2503 17 measures measure VBZ cord-023095-4dannjjm 2503 18 pH ph NN cord-023095-4dannjjm 2503 19 , , , cord-023095-4dannjjm 2503 20 pressure pressure NN cord-023095-4dannjjm 2503 21 , , , cord-023095-4dannjjm 2503 22 and and CC cord-023095-4dannjjm 2503 23 temperature temperature NN cord-023095-4dannjjm 2503 24 as as IN cord-023095-4dannjjm 2503 25 it -PRON- PRP cord-023095-4dannjjm 2503 26 passes pass VBZ cord-023095-4dannjjm 2503 27 through through IN cord-023095-4dannjjm 2503 28 the the DT cord-023095-4dannjjm 2503 29 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2503 30 ( ( -LRB- cord-023095-4dannjjm 2503 31 GI GI NNP cord-023095-4dannjjm 2503 32 ) ) -RRB- cord-023095-4dannjjm 2503 33 tract tract NN cord-023095-4dannjjm 2503 34 . . . cord-023095-4dannjjm 2504 1 Analysis analysis NN cord-023095-4dannjjm 2504 2 of of IN cord-023095-4dannjjm 2504 3 this this DT cord-023095-4dannjjm 2504 4 data data NN cord-023095-4dannjjm 2504 5 allows allow VBZ cord-023095-4dannjjm 2504 6 the the DT cord-023095-4dannjjm 2504 7 calculation calculation NN cord-023095-4dannjjm 2504 8 of of IN cord-023095-4dannjjm 2504 9 gastric gastric JJ cord-023095-4dannjjm 2504 10 emptying emptying NN cord-023095-4dannjjm 2504 11 time time NN cord-023095-4dannjjm 2504 12 ( ( -LRB- cord-023095-4dannjjm 2504 13 GET get VB cord-023095-4dannjjm 2504 14 ) ) -RRB- cord-023095-4dannjjm 2504 15 , , , cord-023095-4dannjjm 2504 16 small small JJ cord-023095-4dannjjm 2504 17 and and CC cord-023095-4dannjjm 2504 18 large large JJ cord-023095-4dannjjm 2504 19 bowel bowel NN cord-023095-4dannjjm 2504 20 transit transit NN cord-023095-4dannjjm 2504 21 time time NN cord-023095-4dannjjm 2504 22 ( ( -LRB- cord-023095-4dannjjm 2504 23 SLBTT SLBTT NNP cord-023095-4dannjjm 2504 24 ) ) -RRB- cord-023095-4dannjjm 2504 25 , , , cord-023095-4dannjjm 2504 26 and and CC cord-023095-4dannjjm 2504 27 total total JJ cord-023095-4dannjjm 2504 28 GI GI NNP cord-023095-4dannjjm 2504 29 transit transit NN cord-023095-4dannjjm 2504 30 time time NN cord-023095-4dannjjm 2504 31 ( ( -LRB- cord-023095-4dannjjm 2504 32 TGTT TGTT NNP cord-023095-4dannjjm 2504 33 ) ) -RRB- cord-023095-4dannjjm 2504 34 . . . cord-023095-4dannjjm 2505 1 This this DT cord-023095-4dannjjm 2505 2 study study NN cord-023095-4dannjjm 2505 3 evaluated evaluate VBD cord-023095-4dannjjm 2505 4 the the DT cord-023095-4dannjjm 2505 5 variability variability NN cord-023095-4dannjjm 2505 6 associated associate VBN cord-023095-4dannjjm 2505 7 with with IN cord-023095-4dannjjm 2505 8 repeated repeat VBN cord-023095-4dannjjm 2505 9 measurement measurement NN cord-023095-4dannjjm 2505 10 of of IN cord-023095-4dannjjm 2505 11 GI GI NNP cord-023095-4dannjjm 2505 12 transit transit NN cord-023095-4dannjjm 2505 13 times time NNS cord-023095-4dannjjm 2505 14 and and CC cord-023095-4dannjjm 2505 15 the the DT cord-023095-4dannjjm 2505 16 effect effect NN cord-023095-4dannjjm 2505 17 of of IN cord-023095-4dannjjm 2505 18 oral oral JJ cord-023095-4dannjjm 2505 19 administration administration NN cord-023095-4dannjjm 2505 20 of of IN cord-023095-4dannjjm 2505 21 ranitidine ranitidine NNP cord-023095-4dannjjm 2505 22 ( ( -LRB- cord-023095-4dannjjm 2505 23 Zantac Zantac NNP cord-023095-4dannjjm 2505 24 s s NNP cord-023095-4dannjjm 2505 25 ) ) -RRB- cord-023095-4dannjjm 2505 26 on on IN cord-023095-4dannjjm 2505 27 GI GI NNP cord-023095-4dannjjm 2505 28 transit transit NN cord-023095-4dannjjm 2505 29 times time NNS cord-023095-4dannjjm 2505 30 in in IN cord-023095-4dannjjm 2505 31 dogs dog NNS cord-023095-4dannjjm 2505 32 using use VBG cord-023095-4dannjjm 2505 33 this this DT cord-023095-4dannjjm 2505 34 system system NN cord-023095-4dannjjm 2505 35 . . . cord-023095-4dannjjm 2506 1 It -PRON- PRP cord-023095-4dannjjm 2506 2 was be VBD cord-023095-4dannjjm 2506 3 hypothesized hypothesize VBN cord-023095-4dannjjm 2506 4 that that IN cord-023095-4dannjjm 2506 5 ranitidine ranitidine NN cord-023095-4dannjjm 2506 6 would would MD cord-023095-4dannjjm 2506 7 reduce reduce VB cord-023095-4dannjjm 2506 8 GI GI NNP cord-023095-4dannjjm 2506 9 transit transit NN cord-023095-4dannjjm 2506 10 times time NNS cord-023095-4dannjjm 2506 11 . . . cord-023095-4dannjjm 2507 1 Six six CD cord-023095-4dannjjm 2507 2 privately privately RB cord-023095-4dannjjm 2507 3 owned own VBN cord-023095-4dannjjm 2507 4 healthy healthy JJ cord-023095-4dannjjm 2507 5 adult adult NN cord-023095-4dannjjm 2507 6 dogs dog NNS cord-023095-4dannjjm 2507 7 weighing weigh VBG cord-023095-4dannjjm 2507 8 between between IN cord-023095-4dannjjm 2507 9 25.0 25.0 CD cord-023095-4dannjjm 2507 10 kg kg NNS cord-023095-4dannjjm 2507 11 and and CC cord-023095-4dannjjm 2507 12 41.0 41.0 CD cord-023095-4dannjjm 2507 13 kg kg NNS cord-023095-4dannjjm 2507 14 were be VBD cord-023095-4dannjjm 2507 15 used use VBN cord-023095-4dannjjm 2507 16 . . . cord-023095-4dannjjm 2508 1 On on IN cord-023095-4dannjjm 2508 2 3 3 CD cord-023095-4dannjjm 2508 3 occasions occasion NNS cord-023095-4dannjjm 2508 4 each each DT cord-023095-4dannjjm 2508 5 dog dog NN cord-023095-4dannjjm 2508 6 was be VBD cord-023095-4dannjjm 2508 7 fed feed VBN cord-023095-4dannjjm 2508 8 a a DT cord-023095-4dannjjm 2508 9 standard standard JJ cord-023095-4dannjjm 2508 10 meal meal NN cord-023095-4dannjjm 2508 11 followed follow VBN cord-023095-4dannjjm 2508 12 by by IN cord-023095-4dannjjm 2508 13 oral oral JJ cord-023095-4dannjjm 2508 14 administration administration NN cord-023095-4dannjjm 2508 15 of of IN cord-023095-4dannjjm 2508 16 a a DT cord-023095-4dannjjm 2508 17 capsule capsule NN cord-023095-4dannjjm 2508 18 . . . cord-023095-4dannjjm 2509 1 Data datum NNS cord-023095-4dannjjm 2509 2 were be VBD cord-023095-4dannjjm 2509 3 recorded record VBN cord-023095-4dannjjm 2509 4 until until IN cord-023095-4dannjjm 2509 5 the the DT cord-023095-4dannjjm 2509 6 capsule capsule NN cord-023095-4dannjjm 2509 7 had have VBD cord-023095-4dannjjm 2509 8 passed pass VBN cord-023095-4dannjjm 2509 9 in in IN cord-023095-4dannjjm 2509 10 the the DT cord-023095-4dannjjm 2509 11 dog dog NN cord-023095-4dannjjm 2509 12 's 's POS cord-023095-4dannjjm 2509 13 feces fece NNS cord-023095-4dannjjm 2509 14 . . . cord-023095-4dannjjm 2510 1 On on IN cord-023095-4dannjjm 2510 2 a a DT cord-023095-4dannjjm 2510 3 4th 4th JJ cord-023095-4dannjjm 2510 4 occasion occasion NN cord-023095-4dannjjm 2510 5 each each DT cord-023095-4dannjjm 2510 6 dog dog NN cord-023095-4dannjjm 2510 7 was be VBD cord-023095-4dannjjm 2510 8 given give VBN cord-023095-4dannjjm 2510 9 75 75 CD cord-023095-4dannjjm 2510 10 mg mg NN cord-023095-4dannjjm 2510 11 of of IN cord-023095-4dannjjm 2510 12 ranitidine ranitidine NN cord-023095-4dannjjm 2510 13 PO PO NNP cord-023095-4dannjjm 2510 14 q12 q12 NN cord-023095-4dannjjm 2510 15 hrs hrs NN cord-023095-4dannjjm 2510 16 starting start VBG cord-023095-4dannjjm 2510 17 48 48 CD cord-023095-4dannjjm 2510 18 hrs hrs NN cord-023095-4dannjjm 2510 19 prior prior RB cord-023095-4dannjjm 2510 20 to to IN cord-023095-4dannjjm 2510 21 testing testing NN cord-023095-4dannjjm 2510 22 . . . cord-023095-4dannjjm 2511 1 The the DT cord-023095-4dannjjm 2511 2 dogs dog NNS cord-023095-4dannjjm 2511 3 were be VBD cord-023095-4dannjjm 2511 4 then then RB cord-023095-4dannjjm 2511 5 fed feed VBN cord-023095-4dannjjm 2511 6 the the DT cord-023095-4dannjjm 2511 7 test test NN cord-023095-4dannjjm 2511 8 meal meal NN cord-023095-4dannjjm 2511 9 and and CC cord-023095-4dannjjm 2511 10 the the DT cord-023095-4dannjjm 2511 11 capsule capsule NN cord-023095-4dannjjm 2511 12 was be VBD cord-023095-4dannjjm 2511 13 administered administer VBN cord-023095-4dannjjm 2511 14 as as IN cord-023095-4dannjjm 2511 15 above above RB cord-023095-4dannjjm 2511 16 . . . cord-023095-4dannjjm 2512 1 Ranitidine Ranitidine NNP cord-023095-4dannjjm 2512 2 was be VBD cord-023095-4dannjjm 2512 3 given give VBN cord-023095-4dannjjm 2512 4 until until IN cord-023095-4dannjjm 2512 5 the the DT cord-023095-4dannjjm 2512 6 capsule capsule NN cord-023095-4dannjjm 2512 7 had have VBD cord-023095-4dannjjm 2512 8 passed pass VBN cord-023095-4dannjjm 2512 9 in in IN cord-023095-4dannjjm 2512 10 the the DT cord-023095-4dannjjm 2512 11 dog dog NN cord-023095-4dannjjm 2512 12 's 's POS cord-023095-4dannjjm 2512 13 feces fece NNS cord-023095-4dannjjm 2512 14 . . . cord-023095-4dannjjm 2513 1 Proprietary proprietary JJ cord-023095-4dannjjm 2513 2 SmartPill SmartPill NNP cord-023095-4dannjjm 2513 3 software software NN cord-023095-4dannjjm 2513 4 was be VBD cord-023095-4dannjjm 2513 5 used use VBN cord-023095-4dannjjm 2513 6 to to TO cord-023095-4dannjjm 2513 7 calculate calculate VB cord-023095-4dannjjm 2513 8 GET GET NNP cord-023095-4dannjjm 2513 9 , , , cord-023095-4dannjjm 2513 10 SLBTT SLBTT NNP cord-023095-4dannjjm 2513 11 , , , cord-023095-4dannjjm 2513 12 TGTT TGTT NNP cord-023095-4dannjjm 2513 13 , , , cord-023095-4dannjjm 2513 14 and and CC cord-023095-4dannjjm 2513 15 the the DT cord-023095-4dannjjm 2513 16 median median JJ cord-023095-4dannjjm 2513 17 gastric gastric JJ cord-023095-4dannjjm 2513 18 pH ph NN cord-023095-4dannjjm 2513 19 ( ( -LRB- cord-023095-4dannjjm 2513 20 MGpH MGpH NNP cord-023095-4dannjjm 2513 21 ) ) -RRB- cord-023095-4dannjjm 2513 22 . . . cord-023095-4dannjjm 2514 1 Mean mean JJ cord-023095-4dannjjm 2514 2 intra intra JJ cord-023095-4dannjjm 2514 3 - - JJ cord-023095-4dannjjm 2514 4 individual individual JJ cord-023095-4dannjjm 2514 5 and and CC cord-023095-4dannjjm 2514 6 inter inter JJ cord-023095-4dannjjm 2514 7 - - JJ cord-023095-4dannjjm 2514 8 individual individual JJ cord-023095-4dannjjm 2514 9 coefficients coefficient NNS cord-023095-4dannjjm 2514 10 of of IN cord-023095-4dannjjm 2514 11 variation variation NN cord-023095-4dannjjm 2514 12 ( ( -LRB- cord-023095-4dannjjm 2514 13 CV% CV% NNP cord-023095-4dannjjm 2514 14 ) ) -RRB- cord-023095-4dannjjm 2514 15 were be VBD cord-023095-4dannjjm 2514 16 calculated calculate VBN cord-023095-4dannjjm 2514 17 for for IN cord-023095-4dannjjm 2514 18 GET get VB cord-023095-4dannjjm 2514 19 , , , cord-023095-4dannjjm 2514 20 SLBTT SLBTT NNP cord-023095-4dannjjm 2514 21 , , , cord-023095-4dannjjm 2514 22 and and CC cord-023095-4dannjjm 2514 23 TTT TTT NNP cord-023095-4dannjjm 2514 24 for for IN cord-023095-4dannjjm 2514 25 the the DT cord-023095-4dannjjm 2514 26 first first JJ cord-023095-4dannjjm 2514 27 3 3 CD cord-023095-4dannjjm 2514 28 time time NN cord-023095-4dannjjm 2514 29 points point NNS cord-023095-4dannjjm 2514 30 . . . cord-023095-4dannjjm 2515 1 Transit transit NN cord-023095-4dannjjm 2515 2 times time NNS cord-023095-4dannjjm 2515 3 and and CC cord-023095-4dannjjm 2515 4 gastric gastric JJ cord-023095-4dannjjm 2515 5 pH ph NN cord-023095-4dannjjm 2515 6 recorded record VBN cord-023095-4dannjjm 2515 7 at at IN cord-023095-4dannjjm 2515 8 all all RB cord-023095-4dannjjm 2515 9 4 4 CD cord-023095-4dannjjm 2515 10 time time NN cord-023095-4dannjjm 2515 11 points point NNS cord-023095-4dannjjm 2515 12 were be VBD cord-023095-4dannjjm 2515 13 compared compare VBN cord-023095-4dannjjm 2515 14 using use VBG cord-023095-4dannjjm 2515 15 a a DT cord-023095-4dannjjm 2515 16 repeated repeat VBN cord-023095-4dannjjm 2515 17 measures measure NNS cord-023095-4dannjjm 2515 18 ANOVA anova NN cord-023095-4dannjjm 2515 19 . . . cord-023095-4dannjjm 2516 1 Where where WRB cord-023095-4dannjjm 2516 2 significant significant JJ cord-023095-4dannjjm 2516 3 differences difference NNS cord-023095-4dannjjm 2516 4 were be VBD cord-023095-4dannjjm 2516 5 identified identify VBN cord-023095-4dannjjm 2516 6 , , , cord-023095-4dannjjm 2516 7 post post VB cord-023095-4dannjjm 2516 8 - - JJ cord-023095-4dannjjm 2516 9 hoc hoc JJ cord-023095-4dannjjm 2516 10 testing testing NN cord-023095-4dannjjm 2516 11 was be VBD cord-023095-4dannjjm 2516 12 performed perform VBN cord-023095-4dannjjm 2516 13 using use VBG cord-023095-4dannjjm 2516 14 a a DT cord-023095-4dannjjm 2516 15 Bonferroni Bonferroni NNP cord-023095-4dannjjm 2516 16 's 's POS cord-023095-4dannjjm 2516 17 multiple multiple JJ cord-023095-4dannjjm 2516 18 comparisons comparison NNS cord-023095-4dannjjm 2516 19 test test NN cord-023095-4dannjjm 2516 20 . . . cord-023095-4dannjjm 2517 1 Significance significance NN cord-023095-4dannjjm 2517 2 was be VBD cord-023095-4dannjjm 2517 3 set set VBN cord-023095-4dannjjm 2517 4 at at IN cord-023095-4dannjjm 2517 5 p p NN cord-023095-4dannjjm 2517 6 o o NN cord-023095-4dannjjm 2517 7 0.05 0.05 CD cord-023095-4dannjjm 2517 8 . . . cord-023095-4dannjjm 2518 1 A a DT cord-023095-4dannjjm 2518 2 sharp sharp JJ cord-023095-4dannjjm 2518 3 rise rise NN cord-023095-4dannjjm 2518 4 in in IN cord-023095-4dannjjm 2518 5 pH pH NNP cord-023095-4dannjjm 2518 6 indicating indicate VBG cord-023095-4dannjjm 2518 7 exit exit NN cord-023095-4dannjjm 2518 8 of of IN cord-023095-4dannjjm 2518 9 the the DT cord-023095-4dannjjm 2518 10 capsule capsule NN cord-023095-4dannjjm 2518 11 from from IN cord-023095-4dannjjm 2518 12 the the DT cord-023095-4dannjjm 2518 13 stomach stomach NN cord-023095-4dannjjm 2518 14 was be VBD cord-023095-4dannjjm 2518 15 identified identify VBN cord-023095-4dannjjm 2518 16 in in IN cord-023095-4dannjjm 2518 17 each each DT cord-023095-4dannjjm 2518 18 experiment experiment NN cord-023095-4dannjjm 2518 19 . . . cord-023095-4dannjjm 2519 1 Mean mean JJ cord-023095-4dannjjm 2519 2 ( ( -LRB- cord-023095-4dannjjm 2519 3 AE AE NNP cord-023095-4dannjjm 2519 4 SD SD NNP cord-023095-4dannjjm 2519 5 ) ) -RRB- cord-023095-4dannjjm 2519 6 GET get VBP cord-023095-4dannjjm 2519 7 , , , cord-023095-4dannjjm 2519 8 SLBTT SLBTT NNP cord-023095-4dannjjm 2519 9 , , , cord-023095-4dannjjm 2519 10 and and CC cord-023095-4dannjjm 2519 11 TGTT TGTT NNP cord-023095-4dannjjm 2519 12 without without IN cord-023095-4dannjjm 2519 13 ranitidine ranitidine NN cord-023095-4dannjjm 2519 14 were be VBD cord-023095-4dannjjm 2519 15 775 775 CD cord-023095-4dannjjm 2519 16 AE AE NNP cord-023095-4dannjjm 2519 17 144 144 CD cord-023095-4dannjjm 2519 18 , , , cord-023095-4dannjjm 2519 19 1563 1563 CD cord-023095-4dannjjm 2519 20 AE AE NNP cord-023095-4dannjjm 2519 21 614 614 CD cord-023095-4dannjjm 2519 22 , , , cord-023095-4dannjjm 2519 23 and and CC cord-023095-4dannjjm 2519 24 2338 2338 CD cord-023095-4dannjjm 2519 25 AE AE NNP cord-023095-4dannjjm 2519 26 577 577 CD cord-023095-4dannjjm 2519 27 min min NN cord-023095-4dannjjm 2519 28 , , , cord-023095-4dannjjm 2519 29 respectively respectively RB cord-023095-4dannjjm 2519 30 . . . cord-023095-4dannjjm 2520 1 Mean mean VB cord-023095-4dannjjm 2520 2 GET get VB cord-023095-4dannjjm 2520 3 , , , cord-023095-4dannjjm 2520 4 SLBTT SLBTT NNP cord-023095-4dannjjm 2520 5 , , , cord-023095-4dannjjm 2520 6 and and CC cord-023095-4dannjjm 2520 7 TGTT TGTT NNP cord-023095-4dannjjm 2520 8 during during IN cord-023095-4dannjjm 2520 9 treatment treatment NN cord-023095-4dannjjm 2520 10 with with IN cord-023095-4dannjjm 2520 11 ranitidine ranitidine NN cord-023095-4dannjjm 2520 12 were be VBD cord-023095-4dannjjm 2520 13 719 719 CD cord-023095-4dannjjm 2520 14 AE AE NNP cord-023095-4dannjjm 2520 15 11 11 CD cord-023095-4dannjjm 2520 16 , , , cord-023095-4dannjjm 2520 17 1442 1442 CD cord-023095-4dannjjm 2520 18 AE AE NNP cord-023095-4dannjjm 2520 19 885 885 CD cord-023095-4dannjjm 2520 20 , , , cord-023095-4dannjjm 2520 21 and and CC cord-023095-4dannjjm 2520 22 2155 2155 CD cord-023095-4dannjjm 2520 23 AE AE NNP cord-023095-4dannjjm 2520 24 897 897 CD cord-023095-4dannjjm 2520 25 min min NN cord-023095-4dannjjm 2520 26 , , , cord-023095-4dannjjm 2520 27 respectively respectively RB cord-023095-4dannjjm 2520 28 . . . cord-023095-4dannjjm 2521 1 Mean mean JJ cord-023095-4dannjjm 2521 2 intra intra JJ cord-023095-4dannjjm 2521 3 - - JJ cord-023095-4dannjjm 2521 4 individual individual JJ cord-023095-4dannjjm 2521 5 CV% cv% NN cord-023095-4dannjjm 2521 6 before before IN cord-023095-4dannjjm 2521 7 ranitidine ranitidine NN cord-023095-4dannjjm 2521 8 for for IN cord-023095-4dannjjm 2521 9 GET get VB cord-023095-4dannjjm 2521 10 , , , cord-023095-4dannjjm 2521 11 SLBTT SLBTT NNP cord-023095-4dannjjm 2521 12 , , , cord-023095-4dannjjm 2521 13 and and CC cord-023095-4dannjjm 2521 14 TGTT TGTT NNP cord-023095-4dannjjm 2521 15 were be VBD cord-023095-4dannjjm 2521 16 12.9 12.9 CD cord-023095-4dannjjm 2521 17 , , , cord-023095-4dannjjm 2521 18 29.7 29.7 CD cord-023095-4dannjjm 2521 19 , , , cord-023095-4dannjjm 2521 20 and and CC cord-023095-4dannjjm 2521 21 17.8 17.8 CD cord-023095-4dannjjm 2521 22 % % NN cord-023095-4dannjjm 2521 23 , , , cord-023095-4dannjjm 2521 24 respectively respectively RB cord-023095-4dannjjm 2521 25 . . . cord-023095-4dannjjm 2522 1 Mean mean VB cord-023095-4dannjjm 2522 2 inter inter JJ cord-023095-4dannjjm 2522 3 - - JJ cord-023095-4dannjjm 2522 4 individual individual JJ cord-023095-4dannjjm 2522 5 CV% cv% NN cord-023095-4dannjjm 2522 6 before before IN cord-023095-4dannjjm 2522 7 treatment treatment NN cord-023095-4dannjjm 2522 8 with with IN cord-023095-4dannjjm 2522 9 ranitidine ranitidine NN cord-023095-4dannjjm 2522 10 for for IN cord-023095-4dannjjm 2522 11 GET get VB cord-023095-4dannjjm 2522 12 , , , cord-023095-4dannjjm 2522 13 SLBTT SLBTT NNP cord-023095-4dannjjm 2522 14 , , , cord-023095-4dannjjm 2522 15 and and CC cord-023095-4dannjjm 2522 16 TTT TTT NNP cord-023095-4dannjjm 2522 17 were be VBD cord-023095-4dannjjm 2522 18 16.1 16.1 CD cord-023095-4dannjjm 2522 19 , , , cord-023095-4dannjjm 2522 20 40.5 40.5 CD cord-023095-4dannjjm 2522 21 , , , cord-023095-4dannjjm 2522 22 and and CC cord-023095-4dannjjm 2522 23 24.7 24.7 CD cord-023095-4dannjjm 2522 24 % % NN cord-023095-4dannjjm 2522 25 , , , cord-023095-4dannjjm 2522 26 respectively respectively RB cord-023095-4dannjjm 2522 27 . . . cord-023095-4dannjjm 2523 1 No no DT cord-023095-4dannjjm 2523 2 significant significant JJ cord-023095-4dannjjm 2523 3 differences difference NNS cord-023095-4dannjjm 2523 4 in in IN cord-023095-4dannjjm 2523 5 GET get NN cord-023095-4dannjjm 2523 6 , , , cord-023095-4dannjjm 2523 7 SLBTT SLBTT NNP cord-023095-4dannjjm 2523 8 , , , cord-023095-4dannjjm 2523 9 or or CC cord-023095-4dannjjm 2523 10 TGTT TGTT NNP cord-023095-4dannjjm 2523 11 were be VBD cord-023095-4dannjjm 2523 12 found find VBN cord-023095-4dannjjm 2523 13 at at IN cord-023095-4dannjjm 2523 14 any any DT cord-023095-4dannjjm 2523 15 of of IN cord-023095-4dannjjm 2523 16 the the DT cord-023095-4dannjjm 2523 17 4 4 CD cord-023095-4dannjjm 2523 18 time time NN cord-023095-4dannjjm 2523 19 points point NNS cord-023095-4dannjjm 2523 20 . . . cord-023095-4dannjjm 2524 1 The the DT cord-023095-4dannjjm 2524 2 mean mean JJ cord-023095-4dannjjm 2524 3 MGpH MGpH NNPS cord-023095-4dannjjm 2524 4 during during IN cord-023095-4dannjjm 2524 5 treatment treatment NN cord-023095-4dannjjm 2524 6 with with IN cord-023095-4dannjjm 2524 7 ranitidine ranitidine NN cord-023095-4dannjjm 2524 8 ( ( -LRB- cord-023095-4dannjjm 2524 9 pH pH NNP cord-023095-4dannjjm 2524 10 2.85 2.85 CD cord-023095-4dannjjm 2524 11 ) ) -RRB- cord-023095-4dannjjm 2524 12 was be VBD cord-023095-4dannjjm 2524 13 significantly significantly RB cord-023095-4dannjjm 2524 14 higher high JJR cord-023095-4dannjjm 2524 15 than than IN cord-023095-4dannjjm 2524 16 at at IN cord-023095-4dannjjm 2524 17 all all DT cord-023095-4dannjjm 2524 18 other other JJ cord-023095-4dannjjm 2524 19 time time NN cord-023095-4dannjjm 2524 20 points point NNS cord-023095-4dannjjm 2525 1 ( ( -LRB- cord-023095-4dannjjm 2525 2 overall overall JJ cord-023095-4dannjjm 2525 3 mean mean NN cord-023095-4dannjjm 2525 4 pH pH NNP cord-023095-4dannjjm 2525 5 for for IN cord-023095-4dannjjm 2525 6 the the DT cord-023095-4dannjjm 2525 7 3 3 CD cord-023095-4dannjjm 2525 8 time time NN cord-023095-4dannjjm 2525 9 points point NNS cord-023095-4dannjjm 2525 10 : : : cord-023095-4dannjjm 2525 11 1.73 1.73 CD cord-023095-4dannjjm 2525 12 ; ; : cord-023095-4dannjjm 2525 13 p p NN cord-023095-4dannjjm 2525 14 o o NN cord-023095-4dannjjm 2525 15 0.05 0.05 CD cord-023095-4dannjjm 2525 16 ) ) -RRB- cord-023095-4dannjjm 2525 17 . . . cord-023095-4dannjjm 2526 1 The the DT cord-023095-4dannjjm 2526 2 SmartPill SmartPill NNP cord-023095-4dannjjm 2526 3 system system NN cord-023095-4dannjjm 2526 4 is be VBZ cord-023095-4dannjjm 2526 5 an an DT cord-023095-4dannjjm 2526 6 easy easy JJ cord-023095-4dannjjm 2526 7 to to TO cord-023095-4dannjjm 2526 8 use use VB cord-023095-4dannjjm 2526 9 , , , cord-023095-4dannjjm 2526 10 ambulatory ambulatory JJ cord-023095-4dannjjm 2526 11 , , , cord-023095-4dannjjm 2526 12 non non JJ cord-023095-4dannjjm 2526 13 - - JJ cord-023095-4dannjjm 2526 14 invasive invasive JJ cord-023095-4dannjjm 2526 15 , , , cord-023095-4dannjjm 2526 16 non non JJ cord-023095-4dannjjm 2526 17 - - JJ cord-023095-4dannjjm 2526 18 radioactive radioactive JJ cord-023095-4dannjjm 2526 19 method method NN cord-023095-4dannjjm 2526 20 for for IN cord-023095-4dannjjm 2526 21 assessing assess VBG cord-023095-4dannjjm 2526 22 GI GI NNP cord-023095-4dannjjm 2526 23 transit transit NN cord-023095-4dannjjm 2526 24 times time NNS cord-023095-4dannjjm 2526 25 in in IN cord-023095-4dannjjm 2526 26 medium medium NN cord-023095-4dannjjm 2526 27 to to IN cord-023095-4dannjjm 2526 28 large large JJ cord-023095-4dannjjm 2526 29 breed breed NN cord-023095-4dannjjm 2526 30 dogs dog NNS cord-023095-4dannjjm 2526 31 . . . cord-023095-4dannjjm 2527 1 Measurements measurement NNS cord-023095-4dannjjm 2527 2 of of IN cord-023095-4dannjjm 2527 3 GI GI NNP cord-023095-4dannjjm 2527 4 transit transit NN cord-023095-4dannjjm 2527 5 times time NNS cord-023095-4dannjjm 2527 6 , , , cord-023095-4dannjjm 2527 7 especially especially RB cord-023095-4dannjjm 2527 8 SLBTT SLBTT NNP cord-023095-4dannjjm 2527 9 , , , cord-023095-4dannjjm 2527 10 were be VBD cord-023095-4dannjjm 2527 11 subject subject JJ cord-023095-4dannjjm 2527 12 to to IN cord-023095-4dannjjm 2527 13 considerable considerable JJ cord-023095-4dannjjm 2527 14 intra intra JJ cord-023095-4dannjjm 2527 15 - - JJ cord-023095-4dannjjm 2527 16 individual individual JJ cord-023095-4dannjjm 2527 17 and and CC cord-023095-4dannjjm 2527 18 interindividual interindividual JJ cord-023095-4dannjjm 2527 19 variation variation NN cord-023095-4dannjjm 2527 20 . . . cord-023095-4dannjjm 2528 1 No no DT cord-023095-4dannjjm 2528 2 significant significant JJ cord-023095-4dannjjm 2528 3 effect effect NN cord-023095-4dannjjm 2528 4 of of IN cord-023095-4dannjjm 2528 5 oral oral JJ cord-023095-4dannjjm 2528 6 ranitidine ranitidine NN cord-023095-4dannjjm 2528 7 on on IN cord-023095-4dannjjm 2528 8 GI GI NNP cord-023095-4dannjjm 2528 9 motility motility NN cord-023095-4dannjjm 2528 10 was be VBD cord-023095-4dannjjm 2528 11 identified identify VBN cord-023095-4dannjjm 2528 12 in in IN cord-023095-4dannjjm 2528 13 this this DT cord-023095-4dannjjm 2528 14 group group NN cord-023095-4dannjjm 2528 15 of of IN cord-023095-4dannjjm 2528 16 dogs dog NNS cord-023095-4dannjjm 2528 17 . . . cord-023095-4dannjjm 2529 1 However however RB cord-023095-4dannjjm 2529 2 , , , cord-023095-4dannjjm 2529 3 as as IN cord-023095-4dannjjm 2529 4 expected expect VBN cord-023095-4dannjjm 2529 5 , , , cord-023095-4dannjjm 2529 6 oral oral JJ cord-023095-4dannjjm 2529 7 ranitidine ranitidine NN cord-023095-4dannjjm 2529 8 caused cause VBD cord-023095-4dannjjm 2529 9 a a DT cord-023095-4dannjjm 2529 10 significant significant JJ cord-023095-4dannjjm 2529 11 increase increase NN cord-023095-4dannjjm 2529 12 in in IN cord-023095-4dannjjm 2529 13 gastric gastric JJ cord-023095-4dannjjm 2529 14 pH. ph. NN cord-023095-4dannjjm 2529 15 The the DT cord-023095-4dannjjm 2529 16 intestinal intestinal JJ cord-023095-4dannjjm 2529 17 microbiota microbiota NN cord-023095-4dannjjm 2529 18 has have VBZ cord-023095-4dannjjm 2529 19 been be VBN cord-023095-4dannjjm 2529 20 implicated implicate VBN cord-023095-4dannjjm 2529 21 in in IN cord-023095-4dannjjm 2529 22 the the DT cord-023095-4dannjjm 2529 23 pathogenesis pathogenesis NN cord-023095-4dannjjm 2529 24 of of IN cord-023095-4dannjjm 2529 25 various various JJ cord-023095-4dannjjm 2529 26 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2529 27 disorders disorder NNS cord-023095-4dannjjm 2529 28 in in IN cord-023095-4dannjjm 2529 29 both both DT cord-023095-4dannjjm 2529 30 humans human NNS cord-023095-4dannjjm 2529 31 and and CC cord-023095-4dannjjm 2529 32 dogs dog NNS cord-023095-4dannjjm 2529 33 . . . cord-023095-4dannjjm 2530 1 Recent recent JJ cord-023095-4dannjjm 2530 2 metagenomic metagenomic JJ cord-023095-4dannjjm 2530 3 data datum NNS cord-023095-4dannjjm 2530 4 suggest suggest VBP cord-023095-4dannjjm 2530 5 that that IN cord-023095-4dannjjm 2530 6 specific specific JJ cord-023095-4dannjjm 2530 7 bacterial bacterial JJ cord-023095-4dannjjm 2530 8 groups group NNS cord-023095-4dannjjm 2530 9 , , , cord-023095-4dannjjm 2530 10 including include VBG cord-023095-4dannjjm 2530 11 bacteria bacteria NNS cord-023095-4dannjjm 2530 12 within within IN cord-023095-4dannjjm 2530 13 the the DT cord-023095-4dannjjm 2530 14 Clostridium clostridium NN cord-023095-4dannjjm 2530 15 clusters cluster NNS cord-023095-4dannjjm 2530 16 IV IV NNP cord-023095-4dannjjm 2530 17 and and CC cord-023095-4dannjjm 2530 18 XIVa XIVa NNP cord-023095-4dannjjm 2530 19 ( ( -LRB- cord-023095-4dannjjm 2530 20 i.e. i.e. FW cord-023095-4dannjjm 2530 21 , , , cord-023095-4dannjjm 2530 22 Faecalibacterium Faecalibacterium NNP cord-023095-4dannjjm 2530 23 spp spp NNS cord-023095-4dannjjm 2530 24 . . . cord-023095-4dannjjm 2531 1 , , , cord-023095-4dannjjm 2531 2 Ruminococcaceae Ruminococcaceae NNP cord-023095-4dannjjm 2531 3 , , , cord-023095-4dannjjm 2531 4 and and CC cord-023095-4dannjjm 2531 5 Lachnospiraceae Lachnospiraceae NNP cord-023095-4dannjjm 2531 6 ) ) -RRB- cord-023095-4dannjjm 2531 7 and and CC cord-023095-4dannjjm 2531 8 Bifidobacterium Bifidobacterium NNP cord-023095-4dannjjm 2531 9 spp spp NNS cord-023095-4dannjjm 2531 10 . . . cord-023095-4dannjjm 2532 1 are be VBP cord-023095-4dannjjm 2532 2 decreased decrease VBN cord-023095-4dannjjm 2532 3 , , , cord-023095-4dannjjm 2532 4 while while IN cord-023095-4dannjjm 2532 5 Proteobacteria Proteobacteria NNP cord-023095-4dannjjm 2532 6 are be VBP cord-023095-4dannjjm 2532 7 increased increase VBN cord-023095-4dannjjm 2532 8 in in IN cord-023095-4dannjjm 2532 9 dogs dog NNS cord-023095-4dannjjm 2532 10 with with IN cord-023095-4dannjjm 2532 11 clinical clinical JJ cord-023095-4dannjjm 2532 12 signs sign NNS cord-023095-4dannjjm 2532 13 of of IN cord-023095-4dannjjm 2532 14 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2532 15 disease disease NN cord-023095-4dannjjm 2532 16 . . . cord-023095-4dannjjm 2533 1 The the DT cord-023095-4dannjjm 2533 2 objective objective NN cord-023095-4dannjjm 2533 3 of of IN cord-023095-4dannjjm 2533 4 this this DT cord-023095-4dannjjm 2533 5 study study NN cord-023095-4dannjjm 2533 6 was be VBD cord-023095-4dannjjm 2533 7 to to TO cord-023095-4dannjjm 2533 8 establish establish VB cord-023095-4dannjjm 2533 9 quantitative quantitative JJ cord-023095-4dannjjm 2533 10 polymerase polymerase NN cord-023095-4dannjjm 2533 11 chain chain NN cord-023095-4dannjjm 2533 12 reaction reaction NN cord-023095-4dannjjm 2533 13 ( ( -LRB- cord-023095-4dannjjm 2533 14 qPCR qPCR NNP cord-023095-4dannjjm 2533 15 ) ) -RRB- cord-023095-4dannjjm 2533 16 assays assay NNS cord-023095-4dannjjm 2533 17 for for IN cord-023095-4dannjjm 2533 18 these these DT cord-023095-4dannjjm 2533 19 specific specific JJ cord-023095-4dannjjm 2533 20 bacterial bacterial JJ cord-023095-4dannjjm 2533 21 groups group NNS cord-023095-4dannjjm 2533 22 and and CC cord-023095-4dannjjm 2533 23 evaluate evaluate VB cord-023095-4dannjjm 2533 24 their -PRON- PRP$ cord-023095-4dannjjm 2533 25 abundance abundance NN cord-023095-4dannjjm 2533 26 in in IN cord-023095-4dannjjm 2533 27 healthy healthy JJ cord-023095-4dannjjm 2533 28 dogs dog NNS cord-023095-4dannjjm 2533 29 and and CC cord-023095-4dannjjm 2533 30 dogs dog NNS cord-023095-4dannjjm 2533 31 with with IN cord-023095-4dannjjm 2533 32 clinical clinical JJ cord-023095-4dannjjm 2533 33 signs sign NNS cord-023095-4dannjjm 2533 34 of of IN cord-023095-4dannjjm 2533 35 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2533 36 disease disease NN cord-023095-4dannjjm 2533 37 . . . cord-023095-4dannjjm 2534 1 Fecal fecal JJ cord-023095-4dannjjm 2534 2 samples sample NNS cord-023095-4dannjjm 2534 3 were be VBD cord-023095-4dannjjm 2534 4 collected collect VBN cord-023095-4dannjjm 2534 5 from from IN cord-023095-4dannjjm 2534 6 21 21 CD cord-023095-4dannjjm 2534 7 healthy healthy JJ cord-023095-4dannjjm 2534 8 dogs dog NNS cord-023095-4dannjjm 2534 9 ( ( -LRB- cord-023095-4dannjjm 2534 10 14 14 CD cord-023095-4dannjjm 2534 11 females female NNS cord-023095-4dannjjm 2534 12 and and CC cord-023095-4dannjjm 2534 13 7 7 CD cord-023095-4dannjjm 2534 14 males male NNS cord-023095-4dannjjm 2534 15 ) ) -RRB- cord-023095-4dannjjm 2534 16 and and CC cord-023095-4dannjjm 2534 17 20 20 CD cord-023095-4dannjjm 2534 18 dogs dog NNS cord-023095-4dannjjm 2534 19 with with IN cord-023095-4dannjjm 2534 20 clinical clinical JJ cord-023095-4dannjjm 2534 21 signs sign NNS cord-023095-4dannjjm 2534 22 of of IN cord-023095-4dannjjm 2534 23 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2534 24 disease disease NN cord-023095-4dannjjm 2534 25 ( ( -LRB- cord-023095-4dannjjm 2534 26 11 11 CD cord-023095-4dannjjm 2534 27 females female NNS cord-023095-4dannjjm 2534 28 and and CC cord-023095-4dannjjm 2534 29 9 9 CD cord-023095-4dannjjm 2534 30 males male NNS cord-023095-4dannjjm 2534 31 ) ) -RRB- cord-023095-4dannjjm 2534 32 . . . cord-023095-4dannjjm 2535 1 Novel novel JJ cord-023095-4dannjjm 2535 2 quantitative quantitative JJ cord-023095-4dannjjm 2535 3 PCR pcr NN cord-023095-4dannjjm 2535 4 assays assay NNS cord-023095-4dannjjm 2535 5 were be VBD cord-023095-4dannjjm 2535 6 established establish VBN cord-023095-4dannjjm 2535 7 for for IN cord-023095-4dannjjm 2535 8 Faecalibacterium Faecalibacterium NNP cord-023095-4dannjjm 2535 9 spp spp NNS cord-023095-4dannjjm 2535 10 . . . cord-023095-4dannjjm 2536 1 , , , cord-023095-4dannjjm 2536 2 Ruminococcaceae Ruminococcaceae NNP cord-023095-4dannjjm 2536 3 , , , cord-023095-4dannjjm 2536 4 and and CC cord-023095-4dannjjm 2536 5 Lachnospiraceae Lachnospiraceae NNP cord-023095-4dannjjm 2536 6 by by IN cord-023095-4dannjjm 2536 7 aligning align VBG cord-023095-4dannjjm 2536 8 respective respective JJ cord-023095-4dannjjm 2536 9 group group NN cord-023095-4dannjjm 2536 10 specific specific JJ cord-023095-4dannjjm 2536 11 sequences sequence NNS cord-023095-4dannjjm 2536 12 against against IN cord-023095-4dannjjm 2536 13 canine canine JJ cord-023095-4dannjjm 2536 14 specific specific JJ cord-023095-4dannjjm 2536 15 sequences sequence NNS cord-023095-4dannjjm 2536 16 obtained obtain VBN cord-023095-4dannjjm 2536 17 from from IN cord-023095-4dannjjm 2536 18 16S 16S NNP cord-023095-4dannjjm 2536 19 rRNA rRNA NNP cord-023095-4dannjjm 2536 20 gene gene NN cord-023095-4dannjjm 2536 21 clone clone NN cord-023095-4dannjjm 2536 22 libraries library NNS cord-023095-4dannjjm 2536 23 and and CC cord-023095-4dannjjm 2536 24 sequences sequence NNS cord-023095-4dannjjm 2536 25 available available JJ cord-023095-4dannjjm 2536 26 from from IN cord-023095-4dannjjm 2536 27 the the DT cord-023095-4dannjjm 2536 28 Ribosomal Ribosomal NNP cord-023095-4dannjjm 2536 29 Database Database NNP cord-023095-4dannjjm 2536 30 Project Project NNP cord-023095-4dannjjm 2536 31 . . . cord-023095-4dannjjm 2537 1 Primers primer NNS cord-023095-4dannjjm 2537 2 for for IN cord-023095-4dannjjm 2537 3 Bifidobacterium bifidobacterium NN cord-023095-4dannjjm 2537 4 spp spp NNS cord-023095-4dannjjm 2537 5 . . . cord-023095-4dannjjm 2538 1 and and CC cord-023095-4dannjjm 2538 2 Proteobacteria Proteobacteria NNP cord-023095-4dannjjm 2538 3 were be VBD cord-023095-4dannjjm 2538 4 selected select VBN cord-023095-4dannjjm 2538 5 from from IN cord-023095-4dannjjm 2538 6 previously previously RB cord-023095-4dannjjm 2538 7 published publish VBN cord-023095-4dannjjm 2538 8 studies study NNS cord-023095-4dannjjm 2538 9 . . . cord-023095-4dannjjm 2539 1 The the DT cord-023095-4dannjjm 2539 2 specificity specificity NN cord-023095-4dannjjm 2539 3 of of IN cord-023095-4dannjjm 2539 4 the the DT cord-023095-4dannjjm 2539 5 qPCR qPCR NNP cord-023095-4dannjjm 2539 6 assays assay NNS cord-023095-4dannjjm 2539 7 was be VBD cord-023095-4dannjjm 2539 8 confirmed confirm VBN cord-023095-4dannjjm 2539 9 by by IN cord-023095-4dannjjm 2539 10 sequencing sequence VBG cord-023095-4dannjjm 2539 11 of of IN cord-023095-4dannjjm 2539 12 obtained obtain VBN cord-023095-4dannjjm 2539 13 qPCR qPCR NNP cord-023095-4dannjjm 2539 14 amplicons amplicon NNS cord-023095-4dannjjm 2539 15 . . . cord-023095-4dannjjm 2540 1 The the DT cord-023095-4dannjjm 2540 2 bacterial bacterial JJ cord-023095-4dannjjm 2540 3 DNA dna NN cord-023095-4dannjjm 2540 4 abundance abundance NN cord-023095-4dannjjm 2540 5 in in IN cord-023095-4dannjjm 2540 6 fecal fecal JJ cord-023095-4dannjjm 2540 7 samples sample NNS cord-023095-4dannjjm 2540 8 was be VBD cord-023095-4dannjjm 2540 9 compared compare VBN cord-023095-4dannjjm 2540 10 between between IN cord-023095-4dannjjm 2540 11 healthy healthy JJ cord-023095-4dannjjm 2540 12 dogs dog NNS cord-023095-4dannjjm 2540 13 and and CC cord-023095-4dannjjm 2540 14 dogs dog NNS cord-023095-4dannjjm 2540 15 with with IN cord-023095-4dannjjm 2540 16 clinical clinical JJ cord-023095-4dannjjm 2540 17 signs sign NNS cord-023095-4dannjjm 2540 18 of of IN cord-023095-4dannjjm 2540 19 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2540 20 disease disease NN cord-023095-4dannjjm 2540 21 using use VBG cord-023095-4dannjjm 2540 22 a a DT cord-023095-4dannjjm 2540 23 Mann Mann NNP cord-023095-4dannjjm 2540 24 - - HYPH cord-023095-4dannjjm 2540 25 Whitney Whitney NNP cord-023095-4dannjjm 2540 26 U U NNP cord-023095-4dannjjm 2540 27 test test NN cord-023095-4dannjjm 2540 28 . . . cord-023095-4dannjjm 2541 1 Significance significance NN cord-023095-4dannjjm 2541 2 was be VBD cord-023095-4dannjjm 2541 3 set set VBN cord-023095-4dannjjm 2541 4 at at IN cord-023095-4dannjjm 2541 5 p p NN cord-023095-4dannjjm 2541 6 o o NN cord-023095-4dannjjm 2541 7 0.05 0.05 CD cord-023095-4dannjjm 2541 8 . . . cord-023095-4dannjjm 2542 1 A a DT cord-023095-4dannjjm 2542 2 significantly significantly RB cord-023095-4dannjjm 2542 3 lower low JJR cord-023095-4dannjjm 2542 4 abundance abundance NN cord-023095-4dannjjm 2542 5 of of IN cord-023095-4dannjjm 2542 6 Faecalibacterium Faecalibacterium NNP cord-023095-4dannjjm 2542 7 spp spp NNS cord-023095-4dannjjm 2542 8 . . . cord-023095-4dannjjm 2543 1 ( ( -LRB- cord-023095-4dannjjm 2543 2 p p NN cord-023095-4dannjjm 2543 3 o o NN cord-023095-4dannjjm 2543 4 0.01 0.01 CD cord-023095-4dannjjm 2543 5 ) ) -RRB- cord-023095-4dannjjm 2543 6 and and CC cord-023095-4dannjjm 2543 7 Ruminococcaceae Ruminococcaceae NNP cord-023095-4dannjjm 2543 8 ( ( -LRB- cord-023095-4dannjjm 2543 9 p p NN cord-023095-4dannjjm 2543 10 5 5 CD cord-023095-4dannjjm 2543 11 0.02 0.02 CD cord-023095-4dannjjm 2543 12 ) ) -RRB- cord-023095-4dannjjm 2543 13 was be VBD cord-023095-4dannjjm 2543 14 observed observe VBN cord-023095-4dannjjm 2543 15 in in IN cord-023095-4dannjjm 2543 16 dogs dog NNS cord-023095-4dannjjm 2543 17 with with IN cord-023095-4dannjjm 2543 18 clinical clinical JJ cord-023095-4dannjjm 2543 19 signs sign NNS cord-023095-4dannjjm 2543 20 of of IN cord-023095-4dannjjm 2543 21 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2543 22 disease disease NN cord-023095-4dannjjm 2543 23 when when WRB cord-023095-4dannjjm 2543 24 compared compare VBN cord-023095-4dannjjm 2543 25 to to IN cord-023095-4dannjjm 2543 26 healthy healthy JJ cord-023095-4dannjjm 2543 27 dogs dog NNS cord-023095-4dannjjm 2543 28 . . . cord-023095-4dannjjm 2544 1 Proteobacteria Proteobacteria NNP cord-023095-4dannjjm 2544 2 were be VBD cord-023095-4dannjjm 2544 3 more more RBR cord-023095-4dannjjm 2544 4 abundant abundant JJ cord-023095-4dannjjm 2544 5 in in IN cord-023095-4dannjjm 2544 6 dogs dog NNS cord-023095-4dannjjm 2544 7 with with IN cord-023095-4dannjjm 2544 8 clinical clinical JJ cord-023095-4dannjjm 2544 9 signs sign NNS cord-023095-4dannjjm 2544 10 of of IN cord-023095-4dannjjm 2544 11 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2544 12 disease disease NN cord-023095-4dannjjm 2544 13 , , , cord-023095-4dannjjm 2544 14 but but CC cord-023095-4dannjjm 2544 15 this this DT cord-023095-4dannjjm 2544 16 difference difference NN cord-023095-4dannjjm 2544 17 did do VBD cord-023095-4dannjjm 2544 18 not not RB cord-023095-4dannjjm 2544 19 reach reach VB cord-023095-4dannjjm 2544 20 statistical statistical JJ cord-023095-4dannjjm 2544 21 significance significance NN cord-023095-4dannjjm 2544 22 ( ( -LRB- cord-023095-4dannjjm 2544 23 p p NN cord-023095-4dannjjm 2544 24 5 5 CD cord-023095-4dannjjm 2544 25 0.07 0.07 CD cord-023095-4dannjjm 2544 26 ) ) -RRB- cord-023095-4dannjjm 2544 27 . . . cord-023095-4dannjjm 2545 1 There there EX cord-023095-4dannjjm 2545 2 was be VBD cord-023095-4dannjjm 2545 3 no no DT cord-023095-4dannjjm 2545 4 significant significant JJ cord-023095-4dannjjm 2545 5 difference difference NN cord-023095-4dannjjm 2545 6 in in IN cord-023095-4dannjjm 2545 7 the the DT cord-023095-4dannjjm 2545 8 abundance abundance NN cord-023095-4dannjjm 2545 9 of of IN cord-023095-4dannjjm 2545 10 Lachnospiraceae Lachnospiraceae NNP cord-023095-4dannjjm 2545 11 ( ( -LRB- cord-023095-4dannjjm 2545 12 p p NN cord-023095-4dannjjm 2545 13 5 5 CD cord-023095-4dannjjm 2545 14 0.23 0.23 CD cord-023095-4dannjjm 2545 15 ) ) -RRB- cord-023095-4dannjjm 2545 16 and and CC cord-023095-4dannjjm 2545 17 Bifidobacterium Bifidobacterium NNP cord-023095-4dannjjm 2545 18 spp spp NNS cord-023095-4dannjjm 2545 19 . . . cord-023095-4dannjjm 2546 1 ( ( -LRB- cord-023095-4dannjjm 2546 2 p p NN cord-023095-4dannjjm 2546 3 5 5 CD cord-023095-4dannjjm 2546 4 0.77 0.77 CD cord-023095-4dannjjm 2546 5 ) ) -RRB- cord-023095-4dannjjm 2546 6 between between IN cord-023095-4dannjjm 2546 7 both both DT cord-023095-4dannjjm 2546 8 groups group NNS cord-023095-4dannjjm 2546 9 . . . cord-023095-4dannjjm 2547 1 In in IN cord-023095-4dannjjm 2547 2 conclusion conclusion NN cord-023095-4dannjjm 2547 3 , , , cord-023095-4dannjjm 2547 4 we -PRON- PRP cord-023095-4dannjjm 2547 5 established establish VBD cord-023095-4dannjjm 2547 6 novel novel NN cord-023095-4dannjjm 2547 7 qPCR qpcr NN cord-023095-4dannjjm 2547 8 assays assay NNS cord-023095-4dannjjm 2547 9 for for IN cord-023095-4dannjjm 2547 10 Faecalibacterium Faecalibacterium NNP cord-023095-4dannjjm 2547 11 spp spp NNS cord-023095-4dannjjm 2547 12 . . . cord-023095-4dannjjm 2548 1 , , , cord-023095-4dannjjm 2548 2 Ruminococcaceae Ruminococcaceae NNP cord-023095-4dannjjm 2548 3 , , , cord-023095-4dannjjm 2548 4 and and CC cord-023095-4dannjjm 2548 5 Lachnospiraceae Lachnospiraceae NNP cord-023095-4dannjjm 2548 6 . . . cord-023095-4dannjjm 2549 1 We -PRON- PRP cord-023095-4dannjjm 2549 2 observed observe VBD cord-023095-4dannjjm 2549 3 significant significant JJ cord-023095-4dannjjm 2549 4 decreases decrease NNS cord-023095-4dannjjm 2549 5 in in IN cord-023095-4dannjjm 2549 6 the the DT cord-023095-4dannjjm 2549 7 abundance abundance NN cord-023095-4dannjjm 2549 8 of of IN cord-023095-4dannjjm 2549 9 Faecalibacterium Faecalibacterium NNP cord-023095-4dannjjm 2549 10 spp spp NNS cord-023095-4dannjjm 2549 11 . . . cord-023095-4dannjjm 2550 1 and and CC cord-023095-4dannjjm 2550 2 Ruminococcaceae Ruminococcaceae NNP cord-023095-4dannjjm 2550 3 in in IN cord-023095-4dannjjm 2550 4 dogs dog NNS cord-023095-4dannjjm 2550 5 with with IN cord-023095-4dannjjm 2550 6 clinical clinical JJ cord-023095-4dannjjm 2550 7 signs sign NNS cord-023095-4dannjjm 2550 8 of of IN cord-023095-4dannjjm 2550 9 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2550 10 disease disease NN cord-023095-4dannjjm 2550 11 . . . cord-023095-4dannjjm 2551 1 These these DT cord-023095-4dannjjm 2551 2 bacterial bacterial JJ cord-023095-4dannjjm 2551 3 groups group NNS cord-023095-4dannjjm 2551 4 are be VBP cord-023095-4dannjjm 2551 5 considered consider VBN cord-023095-4dannjjm 2551 6 major major JJ cord-023095-4dannjjm 2551 7 short short JJ cord-023095-4dannjjm 2551 8 - - HYPH cord-023095-4dannjjm 2551 9 chain chain NN cord-023095-4dannjjm 2551 10 fatty fatty JJ cord-023095-4dannjjm 2551 11 acid acid NN cord-023095-4dannjjm 2551 12 producers producer NNS cord-023095-4dannjjm 2551 13 and and CC cord-023095-4dannjjm 2551 14 studies study NNS cord-023095-4dannjjm 2551 15 are be VBP cord-023095-4dannjjm 2551 16 warranted warrant VBN cord-023095-4dannjjm 2551 17 to to TO cord-023095-4dannjjm 2551 18 determine determine VB cord-023095-4dannjjm 2551 19 if if IN cord-023095-4dannjjm 2551 20 a a DT cord-023095-4dannjjm 2551 21 decrease decrease NN cord-023095-4dannjjm 2551 22 in in IN cord-023095-4dannjjm 2551 23 these these DT cord-023095-4dannjjm 2551 24 bacterial bacterial JJ cord-023095-4dannjjm 2551 25 groups group NNS cord-023095-4dannjjm 2551 26 is be VBZ cord-023095-4dannjjm 2551 27 associated associate VBN cord-023095-4dannjjm 2551 28 with with IN cord-023095-4dannjjm 2551 29 decreases decrease NNS cord-023095-4dannjjm 2551 30 in in IN cord-023095-4dannjjm 2551 31 short short JJ cord-023095-4dannjjm 2551 32 chain chain NN cord-023095-4dannjjm 2551 33 fatty fatty JJ cord-023095-4dannjjm 2551 34 acid acid NN cord-023095-4dannjjm 2551 35 production production NN cord-023095-4dannjjm 2551 36 . . . cord-023095-4dannjjm 2552 1 Further further JJ cord-023095-4dannjjm 2552 2 studies study NNS cord-023095-4dannjjm 2552 3 are be VBP cord-023095-4dannjjm 2552 4 also also RB cord-023095-4dannjjm 2552 5 needed need VBN cord-023095-4dannjjm 2552 6 to to TO cord-023095-4dannjjm 2552 7 determine determine VB cord-023095-4dannjjm 2552 8 if if IN cord-023095-4dannjjm 2552 9 these these DT cord-023095-4dannjjm 2552 10 bacterial bacterial JJ cord-023095-4dannjjm 2552 11 shifts shift NNS cord-023095-4dannjjm 2552 12 are be VBP cord-023095-4dannjjm 2552 13 associated associate VBN cord-023095-4dannjjm 2552 14 with with IN cord-023095-4dannjjm 2552 15 specific specific JJ cord-023095-4dannjjm 2552 16 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2552 17 disorders disorder NNS cord-023095-4dannjjm 2552 18 . . . cord-023095-4dannjjm 2553 1 The the DT cord-023095-4dannjjm 2553 2 pathogenesis pathogenesis NN cord-023095-4dannjjm 2553 3 of of IN cord-023095-4dannjjm 2553 4 chronic chronic JJ cord-023095-4dannjjm 2553 5 enteropathies enteropathy NNS cord-023095-4dannjjm 2553 6 ( ( -LRB- cord-023095-4dannjjm 2553 7 CE CE NNP cord-023095-4dannjjm 2553 8 ) ) -RRB- cord-023095-4dannjjm 2553 9 in in IN cord-023095-4dannjjm 2553 10 dogs dog NNS cord-023095-4dannjjm 2553 11 likely likely RB cord-023095-4dannjjm 2553 12 involves involve VBZ cord-023095-4dannjjm 2553 13 complex complex JJ cord-023095-4dannjjm 2553 14 interaction interaction NN cord-023095-4dannjjm 2553 15 between between IN cord-023095-4dannjjm 2553 16 the the DT cord-023095-4dannjjm 2553 17 mucosal mucosal JJ cord-023095-4dannjjm 2553 18 immune immune JJ cord-023095-4dannjjm 2553 19 system system NN cord-023095-4dannjjm 2553 20 and and CC cord-023095-4dannjjm 2553 21 the the DT cord-023095-4dannjjm 2553 22 intestinal intestinal JJ cord-023095-4dannjjm 2553 23 microbiota microbiota NN cord-023095-4dannjjm 2553 24 . . . cord-023095-4dannjjm 2554 1 While while IN cord-023095-4dannjjm 2554 2 the the DT cord-023095-4dannjjm 2554 3 application application NN cord-023095-4dannjjm 2554 4 of of IN cord-023095-4dannjjm 2554 5 bacterial bacterial JJ cord-023095-4dannjjm 2554 6 16S 16S NNP cord-023095-4dannjjm 2554 7 rDNA rdna NN cord-023095-4dannjjm 2554 8 sequence sequence NN cord-023095-4dannjjm 2554 9 - - HYPH cord-023095-4dannjjm 2554 10 based base VBN cord-023095-4dannjjm 2554 11 analysis analysis NN cord-023095-4dannjjm 2554 12 has have VBZ cord-023095-4dannjjm 2554 13 shown show VBN cord-023095-4dannjjm 2554 14 an an DT cord-023095-4dannjjm 2554 15 association association NN cord-023095-4dannjjm 2554 16 between between IN cord-023095-4dannjjm 2554 17 altered alter VBN cord-023095-4dannjjm 2554 18 microbial microbial JJ cord-023095-4dannjjm 2554 19 composition composition NN cord-023095-4dannjjm 2554 20 and and CC cord-023095-4dannjjm 2554 21 duodenal duodenal JJ cord-023095-4dannjjm 2554 22 inflammation inflammation NN cord-023095-4dannjjm 2554 23 in in IN cord-023095-4dannjjm 2554 24 dogs dog NNS cord-023095-4dannjjm 2554 25 , , , cord-023095-4dannjjm 2554 26 relatively relatively RB cord-023095-4dannjjm 2554 27 little little JJ cord-023095-4dannjjm 2554 28 is be VBZ cord-023095-4dannjjm 2554 29 known know VBN cord-023095-4dannjjm 2554 30 about about IN cord-023095-4dannjjm 2554 31 alterations alteration NNS cord-023095-4dannjjm 2554 32 in in IN cord-023095-4dannjjm 2554 33 non non JJ cord-023095-4dannjjm 2554 34 - - JJ cord-023095-4dannjjm 2554 35 invasive invasive JJ cord-023095-4dannjjm 2554 36 mucosal mucosal JJ cord-023095-4dannjjm 2554 37 and and CC cord-023095-4dannjjm 2554 38 luminal luminal JJ cord-023095-4dannjjm 2554 39 bacteria bacteria NNS cord-023095-4dannjjm 2554 40 seen see VBN cord-023095-4dannjjm 2554 41 with with IN cord-023095-4dannjjm 2554 42 diseases disease NNS cord-023095-4dannjjm 2554 43 involving involve VBG cord-023095-4dannjjm 2554 44 the the DT cord-023095-4dannjjm 2554 45 ileum ileum NN cord-023095-4dannjjm 2554 46 and and CC cord-023095-4dannjjm 2554 47 colon colon NN cord-023095-4dannjjm 2554 48 . . . cord-023095-4dannjjm 2555 1 The the DT cord-023095-4dannjjm 2555 2 present present JJ cord-023095-4dannjjm 2555 3 study study NN cord-023095-4dannjjm 2555 4 sought seek VBD cord-023095-4dannjjm 2555 5 to to TO cord-023095-4dannjjm 2555 6 evaluate evaluate VB cord-023095-4dannjjm 2555 7 the the DT cord-023095-4dannjjm 2555 8 relationship relationship NN cord-023095-4dannjjm 2555 9 of of IN cord-023095-4dannjjm 2555 10 enteric enteric JJ cord-023095-4dannjjm 2555 11 bacteria bacteria NNS cord-023095-4dannjjm 2555 12 to to TO cord-023095-4dannjjm 2555 13 type type NN cord-023095-4dannjjm 2555 14 and and CC cord-023095-4dannjjm 2555 15 severity severity NN cord-023095-4dannjjm 2555 16 of of IN cord-023095-4dannjjm 2555 17 mucosal mucosal JJ cord-023095-4dannjjm 2555 18 inflammation inflammation NN cord-023095-4dannjjm 2555 19 affecting affect VBG cord-023095-4dannjjm 2555 20 the the DT cord-023095-4dannjjm 2555 21 ileum ileum NN cord-023095-4dannjjm 2555 22 and and CC cord-023095-4dannjjm 2555 23 colon colon NN cord-023095-4dannjjm 2555 24 of of IN cord-023095-4dannjjm 2555 25 dogs dog NNS cord-023095-4dannjjm 2555 26 with with IN cord-023095-4dannjjm 2555 27 CE CE NNP cord-023095-4dannjjm 2555 28 . . . cord-023095-4dannjjm 2556 1 Eleven eleven CD cord-023095-4dannjjm 2556 2 client client NN cord-023095-4dannjjm 2556 3 - - HYPH cord-023095-4dannjjm 2556 4 owned own VBN cord-023095-4dannjjm 2556 5 dogs dog NNS cord-023095-4dannjjm 2556 6 with with IN cord-023095-4dannjjm 2556 7 CE CE NNP cord-023095-4dannjjm 2556 8 involving involve VBG cord-023095-4dannjjm 2556 9 both both CC cord-023095-4dannjjm 2556 10 the the DT cord-023095-4dannjjm 2556 11 small small JJ cord-023095-4dannjjm 2556 12 and and CC cord-023095-4dannjjm 2556 13 large large JJ cord-023095-4dannjjm 2556 14 intestines intestine NNS cord-023095-4dannjjm 2556 15 were be VBD cord-023095-4dannjjm 2556 16 prospectively prospectively RB cord-023095-4dannjjm 2556 17 enrolled enrol VBN cord-023095-4dannjjm 2556 18 . . . cord-023095-4dannjjm 2557 1 CE CE NNP cord-023095-4dannjjm 2557 2 was be VBD cord-023095-4dannjjm 2557 3 diagnosed diagnose VBN cord-023095-4dannjjm 2557 4 on on IN cord-023095-4dannjjm 2557 5 the the DT cord-023095-4dannjjm 2557 6 basis basis NN cord-023095-4dannjjm 2557 7 of of IN cord-023095-4dannjjm 2557 8 a a DT cord-023095-4dannjjm 2557 9 history history NN cord-023095-4dannjjm 2557 10 of of IN cord-023095-4dannjjm 2557 11 chronic chronic JJ cord-023095-4dannjjm 2557 12 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2557 13 signs sign NNS cord-023095-4dannjjm 2557 14 , , , cord-023095-4dannjjm 2557 15 exclusion exclusion NN cord-023095-4dannjjm 2557 16 of of IN cord-023095-4dannjjm 2557 17 identifiable identifiable JJ cord-023095-4dannjjm 2557 18 underlying underlying JJ cord-023095-4dannjjm 2557 19 disorders disorder NNS cord-023095-4dannjjm 2557 20 , , , cord-023095-4dannjjm 2557 21 and and CC cord-023095-4dannjjm 2557 22 histopathologic histopathologic JJ cord-023095-4dannjjm 2557 23 evidence evidence NN cord-023095-4dannjjm 2557 24 of of IN cord-023095-4dannjjm 2557 25 intestinal intestinal JJ cord-023095-4dannjjm 2557 26 inflammation inflammation NN cord-023095-4dannjjm 2557 27 . . . cord-023095-4dannjjm 2558 1 Mucosal Mucosal NNP cord-023095-4dannjjm 2558 2 bacteria bacteria NNS cord-023095-4dannjjm 2558 3 were be VBD cord-023095-4dannjjm 2558 4 detected detect VBN cord-023095-4dannjjm 2558 5 in in IN cord-023095-4dannjjm 2558 6 formalinfixed formalinfixed NNP cord-023095-4dannjjm 2558 7 ileal ileal JJ cord-023095-4dannjjm 2558 8 and and CC cord-023095-4dannjjm 2558 9 colonic colonic JJ cord-023095-4dannjjm 2558 10 tissue tissue NN cord-023095-4dannjjm 2558 11 sections section NNS cord-023095-4dannjjm 2558 12 with with IN cord-023095-4dannjjm 2558 13 fluorescence fluorescence NN cord-023095-4dannjjm 2558 14 in in IN cord-023095-4dannjjm 2558 15 situ situ NN cord-023095-4dannjjm 2558 16 hybridization hybridization NN cord-023095-4dannjjm 2558 17 ( ( -LRB- cord-023095-4dannjjm 2558 18 FISH FISH NNP cord-023095-4dannjjm 2558 19 ) ) -RRB- cord-023095-4dannjjm 2558 20 using use VBG cord-023095-4dannjjm 2558 21 16S 16S NNP cord-023095-4dannjjm 2558 22 rDNA rDNA NNP cord-023095-4dannjjm 2558 23 - - HYPH cord-023095-4dannjjm 2558 24 targeted target VBN cord-023095-4dannjjm 2558 25 probes probe NNS cord-023095-4dannjjm 2558 26 directed direct VBN cord-023095-4dannjjm 2558 27 against against IN cord-023095-4dannjjm 2558 28 all all DT cord-023095-4dannjjm 2558 29 bacteria bacteria NNS cord-023095-4dannjjm 2558 30 , , , cord-023095-4dannjjm 2558 31 Enterobacteriaceae Enterobacteriaceae NNP cord-023095-4dannjjm 2558 32 , , , cord-023095-4dannjjm 2558 33 E. E. NNP cord-023095-4dannjjm 2558 34 coli coli NNS cord-023095-4dannjjm 2558 35 , , , cord-023095-4dannjjm 2558 36 Eubacterium Eubacterium NNP cord-023095-4dannjjm 2558 37 rectale rectale NN cord-023095-4dannjjm 2558 38 - - HYPH cord-023095-4dannjjm 2558 39 Clostridium clostridium NN cord-023095-4dannjjm 2558 40 coccoides coccoide NNS cord-023095-4dannjjm 2558 41 group group NN cord-023095-4dannjjm 2558 42 , , , cord-023095-4dannjjm 2558 43 Bacteroides Bacteroides NNP cord-023095-4dannjjm 2558 44 / / SYM cord-023095-4dannjjm 2558 45 Prevotella Prevotella NNP cord-023095-4dannjjm 2558 46 , , , cord-023095-4dannjjm 2558 47 and and CC cord-023095-4dannjjm 2558 48 Helicobacter Helicobacter NNP cord-023095-4dannjjm 2558 49 spp spp NNS cord-023095-4dannjjm 2558 50 . . . cord-023095-4dannjjm 2559 1 Sections section NNS cord-023095-4dannjjm 2559 2 were be VBD cord-023095-4dannjjm 2559 3 examined examine VBN cord-023095-4dannjjm 2559 4 by by IN cord-023095-4dannjjm 2559 5 epifluorescence epifluorescence NN cord-023095-4dannjjm 2559 6 microscopy microscopy NNS cord-023095-4dannjjm 2559 7 and and CC cord-023095-4dannjjm 2559 8 the the DT cord-023095-4dannjjm 2559 9 number number NN cord-023095-4dannjjm 2559 10 of of IN cord-023095-4dannjjm 2559 11 bacteria bacteria NNS cord-023095-4dannjjm 2559 12 and and CC cord-023095-4dannjjm 2559 13 their -PRON- PRP$ cord-023095-4dannjjm 2559 14 spatial spatial JJ cord-023095-4dannjjm 2559 15 distribution distribution NN cord-023095-4dannjjm 2559 16 ( ( -LRB- cord-023095-4dannjjm 2559 17 luminal luminal JJ cord-023095-4dannjjm 2559 18 , , , cord-023095-4dannjjm 2559 19 superficial superficial JJ cord-023095-4dannjjm 2559 20 mucus mucus NN cord-023095-4dannjjm 2559 21 , , , cord-023095-4dannjjm 2559 22 epithelial epithelial JJ cord-023095-4dannjjm 2559 23 adherent adherent NN cord-023095-4dannjjm 2559 24 , , , cord-023095-4dannjjm 2559 25 within within IN cord-023095-4dannjjm 2559 26 mucosa mucosa NN cord-023095-4dannjjm 2559 27 ) ) -RRB- cord-023095-4dannjjm 2559 28 was be VBD cord-023095-4dannjjm 2559 29 determined determine VBN cord-023095-4dannjjm 2559 30 in in IN cord-023095-4dannjjm 2559 31 ten ten CD cord-023095-4dannjjm 2559 32 60x 60x NNS cord-023095-4dannjjm 2559 33 fields field NNS cord-023095-4dannjjm 2559 34 of of IN cord-023095-4dannjjm 2559 35 each each DT cord-023095-4dannjjm 2559 36 section section NN cord-023095-4dannjjm 2559 37 . . . cord-023095-4dannjjm 2560 1 Microbial microbial JJ cord-023095-4dannjjm 2560 2 composition composition NN cord-023095-4dannjjm 2560 3 in in IN cord-023095-4dannjjm 2560 4 CE CE NNP cord-023095-4dannjjm 2560 5 dogs dog NNS cord-023095-4dannjjm 2560 6 was be VBD cord-023095-4dannjjm 2560 7 compared compare VBN cord-023095-4dannjjm 2560 8 to to IN cord-023095-4dannjjm 2560 9 the the DT cord-023095-4dannjjm 2560 10 ileal ileal JJ cord-023095-4dannjjm 2560 11 / / SYM cord-023095-4dannjjm 2560 12 colonic colonic JJ cord-023095-4dannjjm 2560 13 microbiota microbiota NN cord-023095-4dannjjm 2560 14 of of IN cord-023095-4dannjjm 2560 15 7 7 CD cord-023095-4dannjjm 2560 16 healthy healthy JJ cord-023095-4dannjjm 2560 17 control control NN cord-023095-4dannjjm 2560 18 ( ( -LRB- cord-023095-4dannjjm 2560 19 HC HC NNP cord-023095-4dannjjm 2560 20 ) ) -RRB- cord-023095-4dannjjm 2560 21 dogs dog NNS cord-023095-4dannjjm 2560 22 using use VBG cord-023095-4dannjjm 2560 23 a a DT cord-023095-4dannjjm 2560 24 mixed mixed JJ cord-023095-4dannjjm 2560 25 effect effect NN cord-023095-4dannjjm 2560 26 ANOVA anova NN cord-023095-4dannjjm 2560 27 model model NN cord-023095-4dannjjm 2560 28 . . . cord-023095-4dannjjm 2561 1 P p NN cord-023095-4dannjjm 2561 2 values value NNS cord-023095-4dannjjm 2561 3 o o CD cord-023095-4dannjjm 2561 4 0.05 0.05 CD cord-023095-4dannjjm 2561 5 were be VBD cord-023095-4dannjjm 2561 6 considered consider VBN cord-023095-4dannjjm 2561 7 significant significant JJ cord-023095-4dannjjm 2561 8 . . . cord-023095-4dannjjm 2562 1 The the DT cord-023095-4dannjjm 2562 2 final final JJ cord-023095-4dannjjm 2562 3 diagnoses diagnosis NNS cord-023095-4dannjjm 2562 4 for for IN cord-023095-4dannjjm 2562 5 dogs dog NNS cord-023095-4dannjjm 2562 6 with with IN cord-023095-4dannjjm 2562 7 CE CE NNP cord-023095-4dannjjm 2562 8 included include VBD cord-023095-4dannjjm 2562 9 IBD IBD NNP cord-023095-4dannjjm 2562 10 ( ( -LRB- cord-023095-4dannjjm 2562 11 n n NN cord-023095-4dannjjm 2562 12 5 5 CD cord-023095-4dannjjm 2562 13 8) 8) NNP cord-023095-4dannjjm 2562 14 and and CC cord-023095-4dannjjm 2562 15 lymphosarcoma lymphosarcoma NNP cord-023095-4dannjjm 2562 16 ( ( -LRB- cord-023095-4dannjjm 2562 17 n n NN cord-023095-4dannjjm 2562 18 5 5 CD cord-023095-4dannjjm 2562 19 3 3 CD cord-023095-4dannjjm 2562 20 ) ) -RRB- cord-023095-4dannjjm 2562 21 . . . cord-023095-4dannjjm 2563 1 When when WRB cord-023095-4dannjjm 2563 2 compared compare VBN cord-023095-4dannjjm 2563 3 to to IN cord-023095-4dannjjm 2563 4 HC HC NNP cord-023095-4dannjjm 2563 5 dogs dog NNS cord-023095-4dannjjm 2563 6 , , , cord-023095-4dannjjm 2563 7 dogs dog NNS cord-023095-4dannjjm 2563 8 with with IN cord-023095-4dannjjm 2563 9 CE CE NNP cord-023095-4dannjjm 2563 10 showed show VBD cord-023095-4dannjjm 2563 11 regional regional JJ cord-023095-4dannjjm 2563 12 ( ( -LRB- cord-023095-4dannjjm 2563 13 ileum ileum NN cord-023095-4dannjjm 2563 14 versus versus IN cord-023095-4dannjjm 2563 15 colon colon NN cord-023095-4dannjjm 2563 16 ) ) -RRB- cord-023095-4dannjjm 2563 17 imbalances imbalance NNS cord-023095-4dannjjm 2563 18 in in IN cord-023095-4dannjjm 2563 19 microbiota microbiota NN cord-023095-4dannjjm 2563 20 composition composition NN cord-023095-4dannjjm 2563 21 characterized characterize VBN cord-023095-4dannjjm 2563 22 by by IN cord-023095-4dannjjm 2563 23 selective selective JJ cord-023095-4dannjjm 2563 24 enrichment enrichment NN cord-023095-4dannjjm 2563 25 of of IN cord-023095-4dannjjm 2563 26 mucosa mucosa NN cord-023095-4dannjjm 2563 27 - - HYPH cord-023095-4dannjjm 2563 28 associated associate VBN cord-023095-4dannjjm 2563 29 populations population NNS cord-023095-4dannjjm 2563 30 . . . cord-023095-4dannjjm 2564 1 Evaluation evaluation NN cord-023095-4dannjjm 2564 2 of of IN cord-023095-4dannjjm 2564 3 colonic colonic JJ cord-023095-4dannjjm 2564 4 biopsies biopsy NNS cord-023095-4dannjjm 2564 5 in in IN cord-023095-4dannjjm 2564 6 dogs dog NNS cord-023095-4dannjjm 2564 7 with with IN cord-023095-4dannjjm 2564 8 CE CE NNP cord-023095-4dannjjm 2564 9 showed show VBD cord-023095-4dannjjm 2564 10 that that IN cord-023095-4dannjjm 2564 11 the the DT cord-023095-4dannjjm 2564 12 total total JJ cord-023095-4dannjjm 2564 13 number number NN cord-023095-4dannjjm 2564 14 of of IN cord-023095-4dannjjm 2564 15 bacteria bacteria NNS cord-023095-4dannjjm 2564 16 ( ( -LRB- cord-023095-4dannjjm 2564 17 P p NN cord-023095-4dannjjm 2564 18 o o NN cord-023095-4dannjjm 2564 19 0.04 0.04 CD cord-023095-4dannjjm 2564 20 ) ) -RRB- cord-023095-4dannjjm 2564 21 , , , cord-023095-4dannjjm 2564 22 Clostridium clostridium NN cord-023095-4dannjjm 2564 23 ( ( -LRB- cord-023095-4dannjjm 2564 24 P p NN cord-023095-4dannjjm 2564 25 o o NN cord-023095-4dannjjm 2564 26 0.005 0.005 CD cord-023095-4dannjjm 2564 27 ) ) -RRB- cord-023095-4dannjjm 2564 28 , , , cord-023095-4dannjjm 2564 29 Enterobacteriaceae Enterobacteriaceae NNP cord-023095-4dannjjm 2564 30 ( ( -LRB- cord-023095-4dannjjm 2564 31 P p NN cord-023095-4dannjjm 2564 32 o o NN cord-023095-4dannjjm 2564 33 0.04 0.04 CD cord-023095-4dannjjm 2564 34 ) ) -RRB- cord-023095-4dannjjm 2564 35 and and CC cord-023095-4dannjjm 2564 36 E. E. NNP cord-023095-4dannjjm 2564 37 coli coli NNS cord-023095-4dannjjm 2564 38 ( ( -LRB- cord-023095-4dannjjm 2564 39 P p NN cord-023095-4dannjjm 2564 40 o o NN cord-023095-4dannjjm 2564 41 0.03 0.03 CD cord-023095-4dannjjm 2564 42 ) ) -RRB- cord-023095-4dannjjm 2564 43 were be VBD cord-023095-4dannjjm 2564 44 increased increase VBN cord-023095-4dannjjm 2564 45 in in IN cord-023095-4dannjjm 2564 46 the the DT cord-023095-4dannjjm 2564 47 adherent adherent JJ cord-023095-4dannjjm 2564 48 mucus mucus NN cord-023095-4dannjjm 2564 49 regions region NNS cord-023095-4dannjjm 2564 50 of of IN cord-023095-4dannjjm 2564 51 dogs dog NNS cord-023095-4dannjjm 2564 52 with with IN cord-023095-4dannjjm 2564 53 IBD IBD NNP cord-023095-4dannjjm 2564 54 as as IN cord-023095-4dannjjm 2564 55 compared compare VBN cord-023095-4dannjjm 2564 56 to to IN cord-023095-4dannjjm 2564 57 HC HC NNP cord-023095-4dannjjm 2564 58 dogs dog NNS cord-023095-4dannjjm 2564 59 . . . cord-023095-4dannjjm 2565 1 Total total JJ cord-023095-4dannjjm 2565 2 bacteria bacteria NNS cord-023095-4dannjjm 2565 3 ( ( -LRB- cord-023095-4dannjjm 2565 4 P p NN cord-023095-4dannjjm 2565 5 o o NN cord-023095-4dannjjm 2565 6 0.05 0.05 CD cord-023095-4dannjjm 2565 7 ) ) -RRB- cord-023095-4dannjjm 2565 8 and and CC cord-023095-4dannjjm 2565 9 E. E. NNP cord-023095-4dannjjm 2565 10 coli coli NNS cord-023095-4dannjjm 2565 11 ( ( -LRB- cord-023095-4dannjjm 2565 12 P p NN cord-023095-4dannjjm 2565 13 o o NN cord-023095-4dannjjm 2565 14 0.02 0.02 CD cord-023095-4dannjjm 2565 15 ) ) -RRB- cord-023095-4dannjjm 2565 16 were be VBD cord-023095-4dannjjm 2565 17 also also RB cord-023095-4dannjjm 2565 18 more more RBR cord-023095-4dannjjm 2565 19 numerous numerous JJ cord-023095-4dannjjm 2565 20 in in IN cord-023095-4dannjjm 2565 21 dogs dog NNS cord-023095-4dannjjm 2565 22 with with IN cord-023095-4dannjjm 2565 23 LSA LSA NNP cord-023095-4dannjjm 2565 24 versus versus IN cord-023095-4dannjjm 2565 25 HC HC NNP cord-023095-4dannjjm 2565 26 and and CC cord-023095-4dannjjm 2565 27 IBD IBD NNP cord-023095-4dannjjm 2565 28 dogs dog NNS cord-023095-4dannjjm 2566 1 ( ( -LRB- cord-023095-4dannjjm 2566 2 P p NN cord-023095-4dannjjm 2566 3 o o NN cord-023095-4dannjjm 2566 4 0.04 0.04 CD cord-023095-4dannjjm 2566 5 for for IN cord-023095-4dannjjm 2566 6 E. E. NNP cord-023095-4dannjjm 2566 7 coli coli NNS cord-023095-4dannjjm 2566 8 ) ) -RRB- cord-023095-4dannjjm 2566 9 . . . cord-023095-4dannjjm 2567 1 Ileal ileal NN cord-023095-4dannjjm 2567 2 biopsies biopsy NNS cord-023095-4dannjjm 2567 3 from from IN cord-023095-4dannjjm 2567 4 CE CE NNP cord-023095-4dannjjm 2567 5 dogs dog NNS cord-023095-4dannjjm 2567 6 similarly similarly RB cord-023095-4dannjjm 2567 7 showed show VBD cord-023095-4dannjjm 2567 8 variable variable JJ cord-023095-4dannjjm 2567 9 dysbiosis dysbiosis NN cord-023095-4dannjjm 2567 10 with with IN cord-023095-4dannjjm 2567 11 increased increase VBN cord-023095-4dannjjm 2567 12 total total JJ cord-023095-4dannjjm 2567 13 bacteria bacteria NNS cord-023095-4dannjjm 2567 14 ( ( -LRB- cord-023095-4dannjjm 2567 15 P p NN cord-023095-4dannjjm 2567 16 o o NN cord-023095-4dannjjm 2567 17 0.05 0.05 CD cord-023095-4dannjjm 2567 18 ) ) -RRB- cord-023095-4dannjjm 2567 19 but but CC cord-023095-4dannjjm 2567 20 decreased decrease VBD cord-023095-4dannjjm 2567 21 Helicobacter Helicobacter NNP cord-023095-4dannjjm 2567 22 spp spp NNS cord-023095-4dannjjm 2567 23 ( ( -LRB- cord-023095-4dannjjm 2567 24 P p NN cord-023095-4dannjjm 2567 25 o o NN cord-023095-4dannjjm 2567 26 0.001 0.001 CD cord-023095-4dannjjm 2567 27 ) ) -RRB- cord-023095-4dannjjm 2567 28 and and CC cord-023095-4dannjjm 2567 29 Bacteroides Bacteroides NNP cord-023095-4dannjjm 2567 30 ( ( -LRB- cord-023095-4dannjjm 2567 31 P p NN cord-023095-4dannjjm 2567 32 o o NN cord-023095-4dannjjm 2567 33 0.02 0.02 CD cord-023095-4dannjjm 2567 34 ) ) -RRB- cord-023095-4dannjjm 2567 35 observed observe VBD cord-023095-4dannjjm 2567 36 within within IN cord-023095-4dannjjm 2567 37 inflamed inflamed JJ cord-023095-4dannjjm 2567 38 intestines intestine NNS cord-023095-4dannjjm 2567 39 as as IN cord-023095-4dannjjm 2567 40 compared compare VBN cord-023095-4dannjjm 2567 41 to to IN cord-023095-4dannjjm 2567 42 HC HC NNP cord-023095-4dannjjm 2567 43 tissues tissue NNS cord-023095-4dannjjm 2567 44 . . . cord-023095-4dannjjm 2568 1 The the DT cord-023095-4dannjjm 2568 2 spatial spatial JJ cord-023095-4dannjjm 2568 3 distribution distribution NN cord-023095-4dannjjm 2568 4 of of IN cord-023095-4dannjjm 2568 5 these these DT cord-023095-4dannjjm 2568 6 bacteria bacteria NNS cord-023095-4dannjjm 2568 7 was be VBD cord-023095-4dannjjm 2568 8 also also RB cord-023095-4dannjjm 2568 9 appreciably appreciably RB cord-023095-4dannjjm 2568 10 different different JJ cord-023095-4dannjjm 2568 11 from from IN cord-023095-4dannjjm 2568 12 HC HC NNP cord-023095-4dannjjm 2568 13 dogs dog NNS cord-023095-4dannjjm 2568 14 , , , cord-023095-4dannjjm 2568 15 with with IN cord-023095-4dannjjm 2568 16 higher high JJR cord-023095-4dannjjm 2568 17 numbers number NNS cord-023095-4dannjjm 2568 18 of of IN cord-023095-4dannjjm 2568 19 bacteria bacteria NNS cord-023095-4dannjjm 2568 20 generally generally RB cord-023095-4dannjjm 2568 21 found find VBN cord-023095-4dannjjm 2568 22 within within IN cord-023095-4dannjjm 2568 23 the the DT cord-023095-4dannjjm 2568 24 adherent adherent JJ cord-023095-4dannjjm 2568 25 mucus mucus NN cord-023095-4dannjjm 2568 26 compartment compartment NN cord-023095-4dannjjm 2568 27 as as IN cord-023095-4dannjjm 2568 28 compared compare VBN cord-023095-4dannjjm 2568 29 to to IN cord-023095-4dannjjm 2568 30 other other JJ cord-023095-4dannjjm 2568 31 ileal ileal JJ cord-023095-4dannjjm 2568 32 regions region NNS cord-023095-4dannjjm 2568 33 . . . cord-023095-4dannjjm 2569 1 Our -PRON- PRP$ cord-023095-4dannjjm 2569 2 data datum NNS cord-023095-4dannjjm 2569 3 demonstrate demonstrate VBP cord-023095-4dannjjm 2569 4 that that IN cord-023095-4dannjjm 2569 5 dogs dog NNS cord-023095-4dannjjm 2569 6 with with IN cord-023095-4dannjjm 2569 7 CE ce NN cord-023095-4dannjjm 2569 8 affecting affect VBG cord-023095-4dannjjm 2569 9 the the DT cord-023095-4dannjjm 2569 10 ileum ileum NN cord-023095-4dannjjm 2569 11 and and CC cord-023095-4dannjjm 2569 12 colon colon NN cord-023095-4dannjjm 2569 13 have have VBP cord-023095-4dannjjm 2569 14 altered alter VBN cord-023095-4dannjjm 2569 15 microbiota microbiota NN cord-023095-4dannjjm 2569 16 composition composition NN cord-023095-4dannjjm 2569 17 that that WDT cord-023095-4dannjjm 2569 18 may may MD cord-023095-4dannjjm 2569 19 be be VB cord-023095-4dannjjm 2569 20 a a DT cord-023095-4dannjjm 2569 21 cause cause NN cord-023095-4dannjjm 2569 22 or or CC cord-023095-4dannjjm 2569 23 consequence consequence NN cord-023095-4dannjjm 2569 24 of of IN cord-023095-4dannjjm 2569 25 mucosal mucosal JJ cord-023095-4dannjjm 2569 26 inflammation inflammation NN cord-023095-4dannjjm 2569 27 . . . cord-023095-4dannjjm 2570 1 Recognition recognition NN cord-023095-4dannjjm 2570 2 of of IN cord-023095-4dannjjm 2570 3 these these DT cord-023095-4dannjjm 2570 4 microbiota microbiota NN cord-023095-4dannjjm 2570 5 imbalances imbalance NNS cord-023095-4dannjjm 2570 6 may may MD cord-023095-4dannjjm 2570 7 provide provide VB cord-023095-4dannjjm 2570 8 new new JJ cord-023095-4dannjjm 2570 9 opportunities opportunity NNS cord-023095-4dannjjm 2570 10 for for IN cord-023095-4dannjjm 2570 11 therapeutic therapeutic JJ cord-023095-4dannjjm 2570 12 intervention intervention NN cord-023095-4dannjjm 2570 13 . . . cord-023095-4dannjjm 2571 1 Trichomonads trichomonad NNS cord-023095-4dannjjm 2571 2 have have VBP cord-023095-4dannjjm 2571 3 been be VBN cord-023095-4dannjjm 2571 4 rarely rarely RB cord-023095-4dannjjm 2571 5 reported report VBN cord-023095-4dannjjm 2571 6 in in IN cord-023095-4dannjjm 2571 7 the the DT cord-023095-4dannjjm 2571 8 feces fece NNS cord-023095-4dannjjm 2571 9 of of IN cord-023095-4dannjjm 2571 10 dogs dog NNS cord-023095-4dannjjm 2571 11 and and CC cord-023095-4dannjjm 2571 12 their -PRON- PRP$ cord-023095-4dannjjm 2571 13 pathogenicity pathogenicity NN cord-023095-4dannjjm 2571 14 remains remain VBZ cord-023095-4dannjjm 2571 15 uncertain uncertain JJ cord-023095-4dannjjm 2571 16 . . . cord-023095-4dannjjm 2572 1 Although although IN cord-023095-4dannjjm 2572 2 Pentatrichomonas Pentatrichomonas NNP cord-023095-4dannjjm 2572 3 hominis hominis NN cord-023095-4dannjjm 2572 4 ( ( -LRB- cord-023095-4dannjjm 2572 5 Ph Ph NNP cord-023095-4dannjjm 2572 6 ) ) -RRB- cord-023095-4dannjjm 2572 7 is be VBZ cord-023095-4dannjjm 2572 8 considered consider VBN cord-023095-4dannjjm 2572 9 to to TO cord-023095-4dannjjm 2572 10 be be VB cord-023095-4dannjjm 2572 11 a a DT cord-023095-4dannjjm 2572 12 commensal commensal NN cord-023095-4dannjjm 2572 13 that that WDT cord-023095-4dannjjm 2572 14 may may MD cord-023095-4dannjjm 2572 15 overgrow overgrow VB cord-023095-4dannjjm 2572 16 in in IN cord-023095-4dannjjm 2572 17 dogs dog NNS cord-023095-4dannjjm 2572 18 with with IN cord-023095-4dannjjm 2572 19 other other JJ cord-023095-4dannjjm 2572 20 causes cause NNS cord-023095-4dannjjm 2572 21 of of IN cord-023095-4dannjjm 2572 22 diarrhea diarrhea NN cord-023095-4dannjjm 2572 23 , , , cord-023095-4dannjjm 2572 24 little little JJ cord-023095-4dannjjm 2572 25 is be VBZ cord-023095-4dannjjm 2572 26 known know VBN cord-023095-4dannjjm 2572 27 regarding regard VBG cord-023095-4dannjjm 2572 28 the the DT cord-023095-4dannjjm 2572 29 history history NN cord-023095-4dannjjm 2572 30 , , , cord-023095-4dannjjm 2572 31 clinical clinical JJ cord-023095-4dannjjm 2572 32 presentation presentation NN cord-023095-4dannjjm 2572 33 or or CC cord-023095-4dannjjm 2572 34 prevalence prevalence NN cord-023095-4dannjjm 2572 35 of of IN cord-023095-4dannjjm 2572 36 concurrent concurrent JJ cord-023095-4dannjjm 2572 37 GI GI NNP cord-023095-4dannjjm 2572 38 infections infection NNS cord-023095-4dannjjm 2572 39 in in IN cord-023095-4dannjjm 2572 40 dogs dog NNS cord-023095-4dannjjm 2572 41 with with IN cord-023095-4dannjjm 2572 42 trichomonosis trichomonosis NN cord-023095-4dannjjm 2572 43 . . . cord-023095-4dannjjm 2573 1 The the DT cord-023095-4dannjjm 2573 2 aim aim NN cord-023095-4dannjjm 2573 3 of of IN cord-023095-4dannjjm 2573 4 this this DT cord-023095-4dannjjm 2573 5 study study NN cord-023095-4dannjjm 2573 6 was be VBD cord-023095-4dannjjm 2573 7 to to TO cord-023095-4dannjjm 2573 8 determine determine VB cord-023095-4dannjjm 2573 9 whether whether IN cord-023095-4dannjjm 2573 10 dogs dog NNS cord-023095-4dannjjm 2573 11 with with IN cord-023095-4dannjjm 2573 12 diarrhea diarrhea NN cord-023095-4dannjjm 2573 13 and and CC cord-023095-4dannjjm 2573 14 trichomonosis trichomonosis NN cord-023095-4dannjjm 2573 15 could could MD cord-023095-4dannjjm 2573 16 be be VB cord-023095-4dannjjm 2573 17 distinguished distinguish VBN cord-023095-4dannjjm 2573 18 from from IN cord-023095-4dannjjm 2573 19 dogs dog NNS cord-023095-4dannjjm 2573 20 having have VBG cord-023095-4dannjjm 2573 21 diarrhea diarrhea NN cord-023095-4dannjjm 2573 22 without without IN cord-023095-4dannjjm 2573 23 trichomonosis trichomonosis NN cord-023095-4dannjjm 2573 24 on on IN cord-023095-4dannjjm 2573 25 the the DT cord-023095-4dannjjm 2573 26 basis basis NN cord-023095-4dannjjm 2573 27 of of IN cord-023095-4dannjjm 2573 28 clinical clinical JJ cord-023095-4dannjjm 2573 29 signs sign NNS cord-023095-4dannjjm 2573 30 or or CC cord-023095-4dannjjm 2573 31 presence presence NN cord-023095-4dannjjm 2573 32 of of IN cord-023095-4dannjjm 2573 33 concurrent concurrent JJ cord-023095-4dannjjm 2573 34 enteric enteric JJ cord-023095-4dannjjm 2573 35 infections infection NNS cord-023095-4dannjjm 2573 36 . . . cord-023095-4dannjjm 2574 1 Fecal fecal JJ cord-023095-4dannjjm 2574 2 samples sample NNS cord-023095-4dannjjm 2574 3 from from IN cord-023095-4dannjjm 2574 4 39 39 CD cord-023095-4dannjjm 2574 5 dogs dog NNS cord-023095-4dannjjm 2574 6 were be VBD cord-023095-4dannjjm 2574 7 submitted submit VBN cord-023095-4dannjjm 2574 8 to to IN cord-023095-4dannjjm 2574 9 NCSU NCSU NNP cord-023095-4dannjjm 2574 10 from from IN cord-023095-4dannjjm 2574 11 2007 2007 CD cord-023095-4dannjjm 2574 12 - - SYM cord-023095-4dannjjm 2574 13 2010 2010 CD cord-023095-4dannjjm 2574 14 for for IN cord-023095-4dannjjm 2574 15 Trichomonas Trichomonas NNP cord-023095-4dannjjm 2574 16 spp spp NNP cord-023095-4dannjjm 2574 17 . . . cord-023095-4dannjjm 2575 1 PCR PCR NNP cord-023095-4dannjjm 2575 2 testing testing NN cord-023095-4dannjjm 2575 3 . . . cord-023095-4dannjjm 2576 1 DNA DNA NNP cord-023095-4dannjjm 2576 2 was be VBD cord-023095-4dannjjm 2576 3 extracted extract VBN cord-023095-4dannjjm 2576 4 using use VBG cord-023095-4dannjjm 2576 5 a a DT cord-023095-4dannjjm 2576 6 ZR ZR NNP cord-023095-4dannjjm 2576 7 Fecal fecal JJ cord-023095-4dannjjm 2576 8 DNA dna NN cord-023095-4dannjjm 2576 9 mini mini JJ cord-023095-4dannjjm 2576 10 - - HYPH cord-023095-4dannjjm 2576 11 prep prep JJ cord-023095-4dannjjm 2576 12 kit kit NN cord-023095-4dannjjm 2576 13 and and CC cord-023095-4dannjjm 2576 14 absence absence NN cord-023095-4dannjjm 2576 15 of of IN cord-023095-4dannjjm 2576 16 PCR PCR NNP cord-023095-4dannjjm 2576 17 inhibitors inhibitor NNS cord-023095-4dannjjm 2576 18 verified verify VBN cord-023095-4dannjjm 2576 19 by by IN cord-023095-4dannjjm 2576 20 amplification amplification NN cord-023095-4dannjjm 2576 21 of of IN cord-023095-4dannjjm 2576 22 bacterial bacterial JJ cord-023095-4dannjjm 2576 23 16S 16S NNP cord-023095-4dannjjm 2576 24 rDNA rDNA NNP cord-023095-4dannjjm 2576 25 . . . cord-023095-4dannjjm 2577 1 PCR PCR NNP cord-023095-4dannjjm 2577 2 for for IN cord-023095-4dannjjm 2577 3 Ph Ph NNP cord-023095-4dannjjm 2577 4 and and CC cord-023095-4dannjjm 2577 5 Tritrichomonas Tritrichomonas NNP cord-023095-4dannjjm 2577 6 foetus foetus NN cord-023095-4dannjjm 2577 7 ( ( -LRB- cord-023095-4dannjjm 2577 8 Tf Tf NNP cord-023095-4dannjjm 2577 9 ) ) -RRB- cord-023095-4dannjjm 2577 10 was be VBD cord-023095-4dannjjm 2577 11 performed perform VBN cord-023095-4dannjjm 2577 12 as as RB cord-023095-4dannjjm 2577 13 well well RB cord-023095-4dannjjm 2577 14 as as IN cord-023095-4dannjjm 2577 15 real real JJ cord-023095-4dannjjm 2577 16 - - HYPH cord-023095-4dannjjm 2577 17 time time NN cord-023095-4dannjjm 2577 18 PCR PCR NNP cord-023095-4dannjjm 2577 19 assays assay NNS cord-023095-4dannjjm 2577 20 for for IN cord-023095-4dannjjm 2577 21 9 9 CD cord-023095-4dannjjm 2577 22 possible possible JJ cord-023095-4dannjjm 2577 23 concurrent concurrent JJ cord-023095-4dannjjm 2577 24 enteric enteric JJ cord-023095-4dannjjm 2577 25 infectious infectious JJ cord-023095-4dannjjm 2577 26 agents agent NNS cord-023095-4dannjjm 2577 27 . . . cord-023095-4dannjjm 2578 1 Obtainable obtainable JJ cord-023095-4dannjjm 2578 2 medical medical JJ cord-023095-4dannjjm 2578 3 records record NNS cord-023095-4dannjjm 2578 4 were be VBD cord-023095-4dannjjm 2578 5 reviewed review VBN cord-023095-4dannjjm 2578 6 . . . cord-023095-4dannjjm 2579 1 All all DT cord-023095-4dannjjm 2579 2 submitted submit VBD cord-023095-4dannjjm 2579 3 fecal fecal JJ cord-023095-4dannjjm 2579 4 samples sample NNS cord-023095-4dannjjm 2579 5 were be VBD cord-023095-4dannjjm 2579 6 submitted submit VBN cord-023095-4dannjjm 2579 7 from from IN cord-023095-4dannjjm 2579 8 dogs dog NNS cord-023095-4dannjjm 2579 9 with with IN cord-023095-4dannjjm 2579 10 diarrhea diarrhea NN cord-023095-4dannjjm 2579 11 that that WDT cord-023095-4dannjjm 2579 12 was be VBD cord-023095-4dannjjm 2579 13 variably variably RB cord-023095-4dannjjm 2579 14 described describe VBN cord-023095-4dannjjm 2579 15 as as IN cord-023095-4dannjjm 2579 16 soft soft JJ cord-023095-4dannjjm 2579 17 , , , cord-023095-4dannjjm 2579 18 mucoid mucoid JJ cord-023095-4dannjjm 2579 19 , , , cord-023095-4dannjjm 2579 20 hemorrhagic hemorrhagic JJ cord-023095-4dannjjm 2579 21 , , , cord-023095-4dannjjm 2579 22 or or CC cord-023095-4dannjjm 2579 23 watery watery JJ cord-023095-4dannjjm 2579 24 . . . cord-023095-4dannjjm 2580 1 Mean mean JJ cord-023095-4dannjjm 2580 2 age age NN cord-023095-4dannjjm 2580 3 of of IN cord-023095-4dannjjm 2580 4 the the DT cord-023095-4dannjjm 2580 5 dogs dog NNS cord-023095-4dannjjm 2580 6 was be VBD cord-023095-4dannjjm 2580 7 2.33 2.33 CD cord-023095-4dannjjm 2580 8 years year NNS cord-023095-4dannjjm 2580 9 ( ( -LRB- cord-023095-4dannjjm 2580 10 median median JJ cord-023095-4dannjjm 2580 11 1.9 1.9 CD cord-023095-4dannjjm 2580 12 ; ; : cord-023095-4dannjjm 2580 13 range range NN cord-023095-4dannjjm 2580 14 : : : cord-023095-4dannjjm 2580 15 2.5 2.5 CD cord-023095-4dannjjm 2580 16 - - SYM cord-023095-4dannjjm 2580 17 120 120 CD cord-023095-4dannjjm 2580 18 months month NNS cord-023095-4dannjjm 2580 19 ) ) -RRB- cord-023095-4dannjjm 2580 20 and and CC cord-023095-4dannjjm 2580 21 represented represent VBD cord-023095-4dannjjm 2580 22 a a DT cord-023095-4dannjjm 2580 23 total total NN cord-023095-4dannjjm 2580 24 of of IN cord-023095-4dannjjm 2580 25 24 24 CD cord-023095-4dannjjm 2580 26 breeds breed NNS cord-023095-4dannjjm 2580 27 . . . cord-023095-4dannjjm 2581 1 Ph Ph NNP cord-023095-4dannjjm 2581 2 , , , cord-023095-4dannjjm 2581 3 Tf Tf NNP cord-023095-4dannjjm 2581 4 , , , cord-023095-4dannjjm 2581 5 or or CC cord-023095-4dannjjm 2581 6 concurrent concurrent JJ cord-023095-4dannjjm 2581 7 Ph Ph NNP cord-023095-4dannjjm 2581 8 and and CC cord-023095-4dannjjm 2581 9 Tf Tf NNP cord-023095-4dannjjm 2581 10 were be VBD cord-023095-4dannjjm 2581 11 diagnosed diagnose VBN cord-023095-4dannjjm 2581 12 in in IN cord-023095-4dannjjm 2581 13 18 18 CD cord-023095-4dannjjm 2581 14 , , , cord-023095-4dannjjm 2581 15 1 1 CD cord-023095-4dannjjm 2581 16 , , , cord-023095-4dannjjm 2581 17 and and CC cord-023095-4dannjjm 2581 18 1 1 CD cord-023095-4dannjjm 2581 19 dogs dog NNS cord-023095-4dannjjm 2581 20 respectively respectively RB cord-023095-4dannjjm 2581 21 ( ( -LRB- cord-023095-4dannjjm 2581 22 Group Group NNP cord-023095-4dannjjm 2581 23 A A NNP cord-023095-4dannjjm 2581 24 ) ) -RRB- cord-023095-4dannjjm 2581 25 . . . cord-023095-4dannjjm 2582 1 The the DT cord-023095-4dannjjm 2582 2 remaining remain VBG cord-023095-4dannjjm 2582 3 19 19 CD cord-023095-4dannjjm 2582 4 dogs dog NNS cord-023095-4dannjjm 2582 5 were be VBD cord-023095-4dannjjm 2582 6 negative negative JJ cord-023095-4dannjjm 2582 7 for for IN cord-023095-4dannjjm 2582 8 Ph Ph NNP cord-023095-4dannjjm 2582 9 and and CC cord-023095-4dannjjm 2582 10 Tf Tf NNP cord-023095-4dannjjm 2582 11 by by IN cord-023095-4dannjjm 2582 12 PCR PCR NNP cord-023095-4dannjjm 2583 1 No no DT cord-023095-4dannjjm 2583 2 dogs dog NNS cord-023095-4dannjjm 2583 3 were be VBD cord-023095-4dannjjm 2583 4 identified identify VBN cord-023095-4dannjjm 2583 5 as as IN cord-023095-4dannjjm 2583 6 infected infect VBN cord-023095-4dannjjm 2583 7 with with IN cord-023095-4dannjjm 2583 8 canine canine JJ cord-023095-4dannjjm 2583 9 distemper distemper NN cord-023095-4dannjjm 2583 10 virus virus NN cord-023095-4dannjjm 2583 11 or or CC cord-023095-4dannjjm 2583 12 parvovirus parvovirus NN cord-023095-4dannjjm 2583 13 . . . cord-023095-4dannjjm 2584 1 Five five CD cord-023095-4dannjjm 2584 2 samples sample NNS cord-023095-4dannjjm 2584 3 from from IN cord-023095-4dannjjm 2584 4 each each DT cord-023095-4dannjjm 2584 5 group group NN cord-023095-4dannjjm 2584 6 had have VBD cord-023095-4dannjjm 2584 7 insufficient insufficient JJ cord-023095-4dannjjm 2584 8 quantity quantity NN cord-023095-4dannjjm 2584 9 or or CC cord-023095-4dannjjm 2584 10 quality quality NN cord-023095-4dannjjm 2584 11 of of IN cord-023095-4dannjjm 2584 12 DNA dna NN cord-023095-4dannjjm 2584 13 for for IN cord-023095-4dannjjm 2584 14 concurrent concurrent JJ cord-023095-4dannjjm 2584 15 infectious infectious JJ cord-023095-4dannjjm 2584 16 disease disease NN cord-023095-4dannjjm 2584 17 testing testing NN cord-023095-4dannjjm 2584 18 . . . cord-023095-4dannjjm 2585 1 In in IN cord-023095-4dannjjm 2585 2 this this DT cord-023095-4dannjjm 2585 3 large large JJ cord-023095-4dannjjm 2585 4 study study NN cord-023095-4dannjjm 2585 5 of of IN cord-023095-4dannjjm 2585 6 canine canine JJ cord-023095-4dannjjm 2585 7 trichomonosis trichomonosis NN cord-023095-4dannjjm 2585 8 , , , cord-023095-4dannjjm 2585 9 no no DT cord-023095-4dannjjm 2585 10 differences difference NNS cord-023095-4dannjjm 2585 11 in in IN cord-023095-4dannjjm 2585 12 age age NN cord-023095-4dannjjm 2585 13 , , , cord-023095-4dannjjm 2585 14 clinical clinical JJ cord-023095-4dannjjm 2585 15 signs sign NNS cord-023095-4dannjjm 2585 16 , , , cord-023095-4dannjjm 2585 17 or or CC cord-023095-4dannjjm 2585 18 prevalence prevalence NN cord-023095-4dannjjm 2585 19 and and CC cord-023095-4dannjjm 2585 20 identity identity NN cord-023095-4dannjjm 2585 21 of of IN cord-023095-4dannjjm 2585 22 concurrent concurrent JJ cord-023095-4dannjjm 2585 23 enteric enteric JJ cord-023095-4dannjjm 2585 24 infection infection NN cord-023095-4dannjjm 2585 25 between between IN cord-023095-4dannjjm 2585 26 diarrheic diarrheic NNS cord-023095-4dannjjm 2585 27 dogs dog NNS cord-023095-4dannjjm 2585 28 with with IN cord-023095-4dannjjm 2585 29 or or CC cord-023095-4dannjjm 2585 30 without without IN cord-023095-4dannjjm 2585 31 Ph Ph NNP cord-023095-4dannjjm 2585 32 were be VBD cord-023095-4dannjjm 2585 33 identified identify VBN cord-023095-4dannjjm 2585 34 . . . cord-023095-4dannjjm 2586 1 Thus thus RB cord-023095-4dannjjm 2586 2 , , , cord-023095-4dannjjm 2586 3 these these DT cord-023095-4dannjjm 2586 4 findings finding NNS cord-023095-4dannjjm 2586 5 do do VBP cord-023095-4dannjjm 2586 6 not not RB cord-023095-4dannjjm 2586 7 appear appear VB cord-023095-4dannjjm 2586 8 to to TO cord-023095-4dannjjm 2586 9 support support VB cord-023095-4dannjjm 2586 10 a a DT cord-023095-4dannjjm 2586 11 primary primary JJ cord-023095-4dannjjm 2586 12 pathogenic pathogenic JJ cord-023095-4dannjjm 2586 13 role role NN cord-023095-4dannjjm 2586 14 for for IN cord-023095-4dannjjm 2586 15 Ph Ph NNP cord-023095-4dannjjm 2586 16 as as IN cord-023095-4dannjjm 2586 17 a a DT cord-023095-4dannjjm 2586 18 causative causative JJ cord-023095-4dannjjm 2586 19 agent agent NN cord-023095-4dannjjm 2586 20 of of IN cord-023095-4dannjjm 2586 21 diarrhea diarrhea NN cord-023095-4dannjjm 2586 22 in in IN cord-023095-4dannjjm 2586 23 dogs dog NNS cord-023095-4dannjjm 2586 24 . . . cord-023095-4dannjjm 2587 1 Gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2587 2 motility motility NN cord-023095-4dannjjm 2587 3 disorders disorder NNS cord-023095-4dannjjm 2587 4 are be VBP cord-023095-4dannjjm 2587 5 a a DT cord-023095-4dannjjm 2587 6 common common JJ cord-023095-4dannjjm 2587 7 clinical clinical JJ cord-023095-4dannjjm 2587 8 problem problem NN cord-023095-4dannjjm 2587 9 in in IN cord-023095-4dannjjm 2587 10 domestic domestic JJ cord-023095-4dannjjm 2587 11 animals animal NNS cord-023095-4dannjjm 2587 12 . . . cord-023095-4dannjjm 2588 1 Many many JJ cord-023095-4dannjjm 2588 2 of of IN cord-023095-4dannjjm 2588 3 the the DT cord-023095-4dannjjm 2588 4 G.I. G.I. NNP cord-023095-4dannjjm 2588 5 motility motility NN cord-023095-4dannjjm 2588 6 disorders disorder NNS cord-023095-4dannjjm 2588 7 have have VBP cord-023095-4dannjjm 2588 8 been be VBN cord-023095-4dannjjm 2588 9 treated treat VBN cord-023095-4dannjjm 2588 10 previously previously RB cord-023095-4dannjjm 2588 11 with with IN cord-023095-4dannjjm 2588 12 5-HT 5-ht CD cord-023095-4dannjjm 2588 13 4 4 CD cord-023095-4dannjjm 2588 14 agonists agonist NNS cord-023095-4dannjjm 2588 15 although although IN cord-023095-4dannjjm 2588 16 limited limited JJ cord-023095-4dannjjm 2588 17 availability availability NN cord-023095-4dannjjm 2588 18 of of IN cord-023095-4dannjjm 2588 19 drugs drug NNS cord-023095-4dannjjm 2588 20 in in IN cord-023095-4dannjjm 2588 21 this this DT cord-023095-4dannjjm 2588 22 classification classification NN cord-023095-4dannjjm 2588 23 have have VBP cord-023095-4dannjjm 2588 24 stimulated stimulate VBN cord-023095-4dannjjm 2588 25 interest interest NN cord-023095-4dannjjm 2588 26 in in IN cord-023095-4dannjjm 2588 27 the the DT cord-023095-4dannjjm 2588 28 use use NN cord-023095-4dannjjm 2588 29 of of IN cord-023095-4dannjjm 2588 30 new new JJ cord-023095-4dannjjm 2588 31 ( ( -LRB- cord-023095-4dannjjm 2588 32 and and CC cord-023095-4dannjjm 2588 33 old old JJ cord-023095-4dannjjm 2588 34 ) ) -RRB- cord-023095-4dannjjm 2588 35 drug drug NN cord-023095-4dannjjm 2588 36 therapies therapy NNS cord-023095-4dannjjm 2588 37 . . . cord-023095-4dannjjm 2589 1 The the DT cord-023095-4dannjjm 2589 2 dopaminergic dopaminergic JJ cord-023095-4dannjjm 2589 3 antagonists antagonist NNS cord-023095-4dannjjm 2589 4 are be VBP cord-023095-4dannjjm 2589 5 a a DT cord-023095-4dannjjm 2589 6 group group NN cord-023095-4dannjjm 2589 7 of of IN cord-023095-4dannjjm 2589 8 drugs drug NNS cord-023095-4dannjjm 2589 9 with with IN cord-023095-4dannjjm 2589 10 well well RB cord-023095-4dannjjm 2589 11 - - HYPH cord-023095-4dannjjm 2589 12 known know VBN cord-023095-4dannjjm 2589 13 anti anti JJ cord-023095-4dannjjm 2589 14 - - JJ cord-023095-4dannjjm 2589 15 emetic emetic JJ cord-023095-4dannjjm 2589 16 effects effect NNS cord-023095-4dannjjm 2589 17 at at IN cord-023095-4dannjjm 2589 18 central central JJ cord-023095-4dannjjm 2589 19 dopamine dopamine NN cord-023095-4dannjjm 2589 20 D D NNP cord-023095-4dannjjm 2589 21 2 2 CD cord-023095-4dannjjm 2589 22 receptors receptor NNS cord-023095-4dannjjm 2589 23 , , , cord-023095-4dannjjm 2589 24 and and CC cord-023095-4dannjjm 2589 25 putative putative JJ cord-023095-4dannjjm 2589 26 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2589 27 prokinetic prokinetic JJ cord-023095-4dannjjm 2589 28 effects effect NNS cord-023095-4dannjjm 2589 29 at at IN cord-023095-4dannjjm 2589 30 peripheral peripheral JJ cord-023095-4dannjjm 2589 31 D d NN cord-023095-4dannjjm 2589 32 receptors receptor NNS cord-023095-4dannjjm 2589 33 . . . cord-023095-4dannjjm 2590 1 Domperidone Domperidone NNP cord-023095-4dannjjm 2590 2 has have VBZ cord-023095-4dannjjm 2590 3 been be VBN cord-023095-4dannjjm 2590 4 shown show VBN cord-023095-4dannjjm 2590 5 , , , cord-023095-4dannjjm 2590 6 for for IN cord-023095-4dannjjm 2590 7 example example NN cord-023095-4dannjjm 2590 8 , , , cord-023095-4dannjjm 2590 9 to to TO cord-023095-4dannjjm 2590 10 reverse reverse VB cord-023095-4dannjjm 2590 11 gastric gastric JJ cord-023095-4dannjjm 2590 12 relaxation relaxation NN cord-023095-4dannjjm 2590 13 induced induce VBN cord-023095-4dannjjm 2590 14 by by IN cord-023095-4dannjjm 2590 15 dopamine dopamine NN cord-023095-4dannjjm 2590 16 infusion infusion NN cord-023095-4dannjjm 2590 17 in in IN cord-023095-4dannjjm 2590 18 the the DT cord-023095-4dannjjm 2590 19 dog dog NN cord-023095-4dannjjm 2590 20 . . . cord-023095-4dannjjm 2591 1 Similar similar JJ cord-023095-4dannjjm 2591 2 studies study NNS cord-023095-4dannjjm 2591 3 have have VBP cord-023095-4dannjjm 2591 4 not not RB cord-023095-4dannjjm 2591 5 been be VBN cord-023095-4dannjjm 2591 6 reported report VBN cord-023095-4dannjjm 2591 7 in in IN cord-023095-4dannjjm 2591 8 the the DT cord-023095-4dannjjm 2591 9 cat cat NN cord-023095-4dannjjm 2591 10 or or CC cord-023095-4dannjjm 2591 11 rabbit rabbit NN cord-023095-4dannjjm 2591 12 , , , cord-023095-4dannjjm 2591 13 two two CD cord-023095-4dannjjm 2591 14 species specie NNS cord-023095-4dannjjm 2591 15 at at IN cord-023095-4dannjjm 2591 16 risk risk NN cord-023095-4dannjjm 2591 17 for for IN cord-023095-4dannjjm 2591 18 distal distal JJ cord-023095-4dannjjm 2591 19 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2591 20 motility motility NN cord-023095-4dannjjm 2591 21 disorders disorder NNS cord-023095-4dannjjm 2591 22 . . . cord-023095-4dannjjm 2592 1 Our -PRON- PRP$ cord-023095-4dannjjm 2592 2 aim aim NN cord-023095-4dannjjm 2592 3 was be VBD cord-023095-4dannjjm 2592 4 to to TO cord-023095-4dannjjm 2592 5 study study VB cord-023095-4dannjjm 2592 6 the the DT cord-023095-4dannjjm 2592 7 effects effect NNS cord-023095-4dannjjm 2592 8 , , , cord-023095-4dannjjm 2592 9 mechanisms mechanism NNS cord-023095-4dannjjm 2592 10 , , , cord-023095-4dannjjm 2592 11 and and CC cord-023095-4dannjjm 2592 12 sites site NNS cord-023095-4dannjjm 2592 13 of of IN cord-023095-4dannjjm 2592 14 action action NN cord-023095-4dannjjm 2592 15 of of IN cord-023095-4dannjjm 2592 16 domperidone domperidone NNP cord-023095-4dannjjm 2592 17 in in IN cord-023095-4dannjjm 2592 18 feline feline JJ cord-023095-4dannjjm 2592 19 colonic colonic JJ cord-023095-4dannjjm 2592 20 and and CC cord-023095-4dannjjm 2592 21 rabbit rabbit NN cord-023095-4dannjjm 2592 22 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2592 23 smooth smooth JJ cord-023095-4dannjjm 2592 24 muscle muscle NN cord-023095-4dannjjm 2592 25 contraction contraction NN cord-023095-4dannjjm 2592 26 . . . cord-023095-4dannjjm 2593 1 Portions portion NNS cord-023095-4dannjjm 2593 2 of of IN cord-023095-4dannjjm 2593 3 stomach stomach NN cord-023095-4dannjjm 2593 4 ( ( -LRB- cord-023095-4dannjjm 2593 5 fundus fundus NN cord-023095-4dannjjm 2593 6 and and CC cord-023095-4dannjjm 2593 7 antrum antrum NN cord-023095-4dannjjm 2593 8 ) ) -RRB- cord-023095-4dannjjm 2593 9 , , , cord-023095-4dannjjm 2593 10 intestine intestine NN cord-023095-4dannjjm 2593 11 ( ( -LRB- cord-023095-4dannjjm 2593 12 duodenum duodenum NN cord-023095-4dannjjm 2593 13 and and CC cord-023095-4dannjjm 2593 14 ileum ileum NN cord-023095-4dannjjm 2593 15 ) ) -RRB- cord-023095-4dannjjm 2593 16 , , , cord-023095-4dannjjm 2593 17 cecum cecum NN cord-023095-4dannjjm 2593 18 ( ( -LRB- cord-023095-4dannjjm 2593 19 rabbits rabbit NNS cord-023095-4dannjjm 2593 20 only only RB cord-023095-4dannjjm 2593 21 ) ) -RRB- cord-023095-4dannjjm 2593 22 , , , cord-023095-4dannjjm 2593 23 and and CC cord-023095-4dannjjm 2593 24 colon colon NN cord-023095-4dannjjm 2593 25 ( ( -LRB- cord-023095-4dannjjm 2593 26 ascending ascend VBG cord-023095-4dannjjm 2593 27 and and CC cord-023095-4dannjjm 2593 28 descending descend VBG cord-023095-4dannjjm 2593 29 ) ) -RRB- cord-023095-4dannjjm 2593 30 were be VBD cord-023095-4dannjjm 2593 31 obtained obtain VBN cord-023095-4dannjjm 2593 32 from from IN cord-023095-4dannjjm 2593 33 healthy healthy JJ cord-023095-4dannjjm 2593 34 cats cat NNS cord-023095-4dannjjm 2593 35 and and CC cord-023095-4dannjjm 2593 36 rabbits rabbit NNS cord-023095-4dannjjm 2593 37 from from IN cord-023095-4dannjjm 2593 38 9 9 CD cord-023095-4dannjjm 2593 39 - - SYM cord-023095-4dannjjm 2593 40 12 12 CD cord-023095-4dannjjm 2593 41 months month NNS cord-023095-4dannjjm 2593 42 of of IN cord-023095-4dannjjm 2593 43 age age NN cord-023095-4dannjjm 2593 44 . . . cord-023095-4dannjjm 2594 1 Longitudinal longitudinal JJ cord-023095-4dannjjm 2594 2 and and CC cord-023095-4dannjjm 2594 3 circular circular JJ cord-023095-4dannjjm 2594 4 smooth smooth JJ cord-023095-4dannjjm 2594 5 muscle muscle NN cord-023095-4dannjjm 2594 6 strips strip NNS cord-023095-4dannjjm 2594 7 from from IN cord-023095-4dannjjm 2594 8 each each DT cord-023095-4dannjjm 2594 9 site site NN cord-023095-4dannjjm 2594 10 were be VBD cord-023095-4dannjjm 2594 11 suspended suspend VBN cord-023095-4dannjjm 2594 12 in in IN cord-023095-4dannjjm 2594 13 physiologic physiologic JJ cord-023095-4dannjjm 2594 14 ( ( -LRB- cord-023095-4dannjjm 2594 15 HEPES hepes NN cord-023095-4dannjjm 2594 16 ) ) -RRB- cord-023095-4dannjjm 2594 17 buffer buffer NN cord-023095-4dannjjm 2594 18 solution solution NN cord-023095-4dannjjm 2594 19 , , , cord-023095-4dannjjm 2594 20 attached attach VBN cord-023095-4dannjjm 2594 21 to to IN cord-023095-4dannjjm 2594 22 isometric isometric JJ cord-023095-4dannjjm 2594 23 force force NN cord-023095-4dannjjm 2594 24 transducers transducer NNS cord-023095-4dannjjm 2594 25 , , , cord-023095-4dannjjm 2594 26 and and CC cord-023095-4dannjjm 2594 27 set set VBD cord-023095-4dannjjm 2594 28 to to TO cord-023095-4dannjjm 2594 29 optimal optimal JJ cord-023095-4dannjjm 2594 30 muscle muscle NN cord-023095-4dannjjm 2594 31 length length NN cord-023095-4dannjjm 2594 32 ( ( -LRB- cord-023095-4dannjjm 2594 33 L l NN cord-023095-4dannjjm 2594 34 o o NN cord-023095-4dannjjm 2594 35 ) ) -RRB- cord-023095-4dannjjm 2594 36 using use VBG cord-023095-4dannjjm 2594 37 acetylcholine acetylcholine NN cord-023095-4dannjjm 2594 38 ( ( -LRB- cord-023095-4dannjjm 2594 39 ACh ACh NNP cord-023095-4dannjjm 2594 40 ; ; : cord-023095-4dannjjm 2594 41 10 10 CD cord-023095-4dannjjm 2594 42 À4 À4 NNP cord-023095-4dannjjm 2594 43 M M NNP cord-023095-4dannjjm 2594 44 ) ) -RRB- cord-023095-4dannjjm 2594 45 . . . cord-023095-4dannjjm 2595 1 Muscle muscle NN cord-023095-4dannjjm 2595 2 strips strip NNS cord-023095-4dannjjm 2595 3 were be VBD cord-023095-4dannjjm 2595 4 treated treat VBN cord-023095-4dannjjm 2595 5 with with IN cord-023095-4dannjjm 2595 6 domperidone domperidone NNP cord-023095-4dannjjm 2595 7 ( ( -LRB- cord-023095-4dannjjm 2595 8 D D NNP cord-023095-4dannjjm 2595 9 ; ; : cord-023095-4dannjjm 2595 10 10 10 CD cord-023095-4dannjjm 2595 11 À8 à8 CD cord-023095-4dannjjm 2595 12 to to IN cord-023095-4dannjjm 2595 13 10 10 CD cord-023095-4dannjjm 2595 14 À4 À4 NNP cord-023095-4dannjjm 2595 15 M M NNP cord-023095-4dannjjm 2595 16 ) ) -RRB- cord-023095-4dannjjm 2595 17 in in IN cord-023095-4dannjjm 2595 18 the the DT cord-023095-4dannjjm 2595 19 presence presence NN cord-023095-4dannjjm 2595 20 or or CC cord-023095-4dannjjm 2595 21 absence absence NN cord-023095-4dannjjm 2595 22 of of IN cord-023095-4dannjjm 2595 23 ACh ACh NNP cord-023095-4dannjjm 2595 24 ( ( -LRB- cord-023095-4dannjjm 2595 25 10 10 CD cord-023095-4dannjjm 2595 26 À8 à8 CD cord-023095-4dannjjm 2595 27 to to IN cord-023095-4dannjjm 2595 28 10 10 CD cord-023095-4dannjjm 2595 29 À4 À4 NNP cord-023095-4dannjjm 2595 30 M M NNP cord-023095-4dannjjm 2595 31 ) ) -RRB- cord-023095-4dannjjm 2595 32 , , , cord-023095-4dannjjm 2595 33 and and CC cord-023095-4dannjjm 2595 34 maximal maximal JJ cord-023095-4dannjjm 2595 35 force force NN cord-023095-4dannjjm 2595 36 output output NN cord-023095-4dannjjm 2595 37 ( ( -LRB- cord-023095-4dannjjm 2595 38 P p NN cord-023095-4dannjjm 2595 39 max max NN cord-023095-4dannjjm 2595 40 ) ) -RRB- cord-023095-4dannjjm 2595 41 was be VBD cord-023095-4dannjjm 2595 42 normalized normalize VBN cord-023095-4dannjjm 2595 43 for for IN cord-023095-4dannjjm 2595 44 cross cross JJ cord-023095-4dannjjm 2595 45 - - JJ cord-023095-4dannjjm 2595 46 sectional sectional JJ cord-023095-4dannjjm 2595 47 area area NN cord-023095-4dannjjm 2595 48 ( ( -LRB- cord-023095-4dannjjm 2595 49 N n NN cord-023095-4dannjjm 2595 50 5 5 CD cord-023095-4dannjjm 2595 51 Â â CD cord-023095-4dannjjm 2595 52 10 10 CD cord-023095-4dannjjm 2595 53 4 4 CD cord-023095-4dannjjm 2595 54 Newtons Newtons NNPS cord-023095-4dannjjm 2595 55 / / SYM cord-023095-4dannjjm 2595 56 m m NN cord-023095-4dannjjm 2595 57 2 2 CD cord-023095-4dannjjm 2595 58 ) ) -RRB- cord-023095-4dannjjm 2595 59 . . . cord-023095-4dannjjm 2596 1 Domperidone Domperidone NNP cord-023095-4dannjjm 2596 2 ( ( -LRB- cord-023095-4dannjjm 2596 3 D D NNP cord-023095-4dannjjm 2596 4 ) ) -RRB- cord-023095-4dannjjm 2596 5 had have VBD cord-023095-4dannjjm 2596 6 a a DT cord-023095-4dannjjm 2596 7 minor minor JJ cord-023095-4dannjjm 2596 8 direct direct JJ cord-023095-4dannjjm 2596 9 effect effect NN cord-023095-4dannjjm 2596 10 of of IN cord-023095-4dannjjm 2596 11 inducing induce VBG cord-023095-4dannjjm 2596 12 feline feline JJ cord-023095-4dannjjm 2596 13 and and CC cord-023095-4dannjjm 2596 14 rabbit rabbit NN cord-023095-4dannjjm 2596 15 gastric gastric JJ cord-023095-4dannjjm 2596 16 , , , cord-023095-4dannjjm 2596 17 cecal cecal JJ cord-023095-4dannjjm 2596 18 , , , cord-023095-4dannjjm 2596 19 and and CC cord-023095-4dannjjm 2596 20 colonic colonic JJ cord-023095-4dannjjm 2596 21 smooth smooth JJ cord-023095-4dannjjm 2596 22 muscle muscle NN cord-023095-4dannjjm 2596 23 contraction contraction NN cord-023095-4dannjjm 2596 24 . . . cord-023095-4dannjjm 2597 1 Direct direct JJ cord-023095-4dannjjm 2597 2 effects effect NNS cord-023095-4dannjjm 2597 3 were be VBD cord-023095-4dannjjm 2597 4 similar similar JJ cord-023095-4dannjjm 2597 5 whether whether IN cord-023095-4dannjjm 2597 6 in in IN cord-023095-4dannjjm 2597 7 the the DT cord-023095-4dannjjm 2597 8 longitudinal longitudinal JJ cord-023095-4dannjjm 2597 9 or or CC cord-023095-4dannjjm 2597 10 circular circular JJ cord-023095-4dannjjm 2597 11 muscle muscle NN cord-023095-4dannjjm 2597 12 orientation orientation NN cord-023095-4dannjjm 2597 13 . . . cord-023095-4dannjjm 2598 1 The the DT cord-023095-4dannjjm 2598 2 direct direct JJ cord-023095-4dannjjm 2598 3 effect effect NN cord-023095-4dannjjm 2598 4 of of IN cord-023095-4dannjjm 2598 5 domperidone domperidone NN cord-023095-4dannjjm 2598 6 was be VBD cord-023095-4dannjjm 2598 7 dose dose NN cord-023095-4dannjjm 2598 8 - - HYPH cord-023095-4dannjjm 2598 9 dependent dependent JJ cord-023095-4dannjjm 2598 10 and and CC cord-023095-4dannjjm 2598 11 maximal maximal JJ cord-023095-4dannjjm 2599 1 ( ( -LRB- cord-023095-4dannjjm 2599 2 feline feline JJ cord-023095-4dannjjm 2599 3 colon colon NN cord-023095-4dannjjm 2599 4 P p NN cord-023095-4dannjjm 2599 5 max max NN cord-023095-4dannjjm 2599 6 5 5 CD cord-023095-4dannjjm 2599 7 0.15 0.15 CD cord-023095-4dannjjm 2599 8 - - HYPH cord-023095-4dannjjm 2599 9 0.22 0.22 CD cord-023095-4dannjjm 2599 10 N n CD cord-023095-4dannjjm 2599 11 ; ; : cord-023095-4dannjjm 2599 12 rabbit rabbit NN cord-023095-4dannjjm 2599 13 colon colon NN cord-023095-4dannjjm 2599 14 P p NN cord-023095-4dannjjm 2599 15 max max NN cord-023095-4dannjjm 2599 16 5 5 CD cord-023095-4dannjjm 2599 17 0.10 0.10 CD cord-023095-4dannjjm 2599 18 - - HYPH cord-023095-4dannjjm 2599 19 0.19 0.19 CD cord-023095-4dannjjm 2599 20 N n CD cord-023095-4dannjjm 2599 21 ) ) -RRB- cord-023095-4dannjjm 2599 22 at at IN cord-023095-4dannjjm 2599 23 a a DT cord-023095-4dannjjm 2599 24 dose dose NN cord-023095-4dannjjm 2599 25 of of IN cord-023095-4dannjjm 2599 26 10 10 CD cord-023095-4dannjjm 2599 27 À4 À4 NNP cord-023095-4dannjjm 2599 28 M. M. NNP cord-023095-4dannjjm 2599 29 Domperidone Domperidone NNP cord-023095-4dannjjm 2599 30 had have VBD cord-023095-4dannjjm 2599 31 a a DT cord-023095-4dannjjm 2599 32 much much RB cord-023095-4dannjjm 2599 33 greater great JJR cord-023095-4dannjjm 2599 34 indirect indirect JJ cord-023095-4dannjjm 2599 35 effect effect NN cord-023095-4dannjjm 2599 36 in in IN cord-023095-4dannjjm 2599 37 augmenting augment VBG cord-023095-4dannjjm 2599 38 cholinergic cholinergic JJ cord-023095-4dannjjm 2599 39 ( ( -LRB- cord-023095-4dannjjm 2599 40 ACh ACh NNP cord-023095-4dannjjm 2599 41 ; ; : cord-023095-4dannjjm 2599 42 10 10 CD cord-023095-4dannjjm 2599 43 À4 À4 NNP cord-023095-4dannjjm 2599 44 M M NNP cord-023095-4dannjjm 2599 45 ) ) -RRB- cord-023095-4dannjjm 2599 46 contractions contraction NNS cord-023095-4dannjjm 2599 47 in in IN cord-023095-4dannjjm 2599 48 feline feline JJ cord-023095-4dannjjm 2599 49 and and CC cord-023095-4dannjjm 2599 50 rabbit rabbit NN cord-023095-4dannjjm 2599 51 gastric gastric JJ cord-023095-4dannjjm 2599 52 , , , cord-023095-4dannjjm 2599 53 cecal cecal JJ cord-023095-4dannjjm 2599 54 , , , cord-023095-4dannjjm 2599 55 and and CC cord-023095-4dannjjm 2599 56 colonic colonic JJ cord-023095-4dannjjm 2599 57 smooth smooth JJ cord-023095-4dannjjm 2599 58 muscle muscle NN cord-023095-4dannjjm 2599 59 . . . cord-023095-4dannjjm 2600 1 Domperidone Domperidone NNP cord-023095-4dannjjm 2600 2 - - HYPH cord-023095-4dannjjm 2600 3 augmented augment VBN cord-023095-4dannjjm 2600 4 cholinergic cholinergic JJ cord-023095-4dannjjm 2600 5 contractions contraction NNS cord-023095-4dannjjm 2600 6 were be VBD cord-023095-4dannjjm 2600 7 157 157 CD cord-023095-4dannjjm 2600 8 - - SYM cord-023095-4dannjjm 2600 9 200 200 CD cord-023095-4dannjjm 2600 10 % % NN cord-023095-4dannjjm 2600 11 ( ( -LRB- cord-023095-4dannjjm 2600 12 feline feline JJ cord-023095-4dannjjm 2600 13 colon colon NN cord-023095-4dannjjm 2600 14 P p NN cord-023095-4dannjjm 2600 15 max max NN cord-023095-4dannjjm 2600 16 5 5 CD cord-023095-4dannjjm 2600 17 1.54 1.54 CD cord-023095-4dannjjm 2600 18 AE AE NNP cord-023095-4dannjjm 2600 19 0.24 0.24 CD cord-023095-4dannjjm 2600 20 N N NNP cord-023095-4dannjjm 2600 21 ACh ACh NNP cord-023095-4dannjjm 2600 22 only only RB cord-023095-4dannjjm 2600 23 ; ; : cord-023095-4dannjjm 2600 24 feline feline JJ cord-023095-4dannjjm 2600 25 colon colon NN cord-023095-4dannjjm 2600 26 P p NN cord-023095-4dannjjm 2600 27 max max NN cord-023095-4dannjjm 2600 28 5 5 CD cord-023095-4dannjjm 2600 29 2.03 2.03 CD cord-023095-4dannjjm 2600 30 AE AE NNP cord-023095-4dannjjm 2600 31 0.23N 0.23n CD cord-023095-4dannjjm 2600 32 ACh ACh NNP cord-023095-4dannjjm 2600 33 1 1 CD cord-023095-4dannjjm 2600 34 D D NNP cord-023095-4dannjjm 2600 35 ) ) -RRB- cord-023095-4dannjjm 2600 36 of of IN cord-023095-4dannjjm 2600 37 baseline baseline JJ cord-023095-4dannjjm 2600 38 cholinergic cholinergic JJ cord-023095-4dannjjm 2600 39 contractions contraction NNS cord-023095-4dannjjm 2600 40 . . . cord-023095-4dannjjm 2601 1 Domperidone Domperidone NNP cord-023095-4dannjjm 2601 2 contractions contraction NNS cord-023095-4dannjjm 2601 3 were be VBD cord-023095-4dannjjm 2601 4 of of IN cord-023095-4dannjjm 2601 5 a a DT cord-023095-4dannjjm 2601 6 similar similar JJ cord-023095-4dannjjm 2601 7 magnitude magnitude NN cord-023095-4dannjjm 2601 8 to to IN cord-023095-4dannjjm 2601 9 those those DT cord-023095-4dannjjm 2601 10 induced induce VBN cord-023095-4dannjjm 2601 11 by by IN cord-023095-4dannjjm 2601 12 cisapride cisapride NN cord-023095-4dannjjm 2601 13 . . . cord-023095-4dannjjm 2602 1 Domperidone Domperidone NNP cord-023095-4dannjjm 2602 2 effects effect NNS cord-023095-4dannjjm 2602 3 were be VBD cord-023095-4dannjjm 2602 4 similar similar JJ cord-023095-4dannjjm 2602 5 in in IN cord-023095-4dannjjm 2602 6 mucosaintact mucosaintact NN cord-023095-4dannjjm 2602 7 and and CC cord-023095-4dannjjm 2602 8 mucosa mucosa RB cord-023095-4dannjjm 2602 9 - - HYPH cord-023095-4dannjjm 2602 10 dissected dissect VBN cord-023095-4dannjjm 2602 11 preparations preparation NNS cord-023095-4dannjjm 2602 12 . . . cord-023095-4dannjjm 2603 1 Domperidone Domperidone NNP cord-023095-4dannjjm 2603 2 contractions contraction NNS cord-023095-4dannjjm 2603 3 were be VBD cord-023095-4dannjjm 2603 4 unaffected unaffected JJ cord-023095-4dannjjm 2603 5 by by IN cord-023095-4dannjjm 2603 6 prazosin prazosin NN cord-023095-4dannjjm 2603 7 ( ( -LRB- cord-023095-4dannjjm 2603 8 a a DT cord-023095-4dannjjm 2603 9 1 1 CD cord-023095-4dannjjm 2603 10 receptor receptor NN cord-023095-4dannjjm 2603 11 antagonist antagonist NN cord-023095-4dannjjm 2603 12 ) ) -RRB- cord-023095-4dannjjm 2603 13 , , , cord-023095-4dannjjm 2603 14 yohimbine yohimbine NN cord-023095-4dannjjm 2603 15 ( ( -LRB- cord-023095-4dannjjm 2603 16 a a DT cord-023095-4dannjjm 2603 17 2 2 CD cord-023095-4dannjjm 2603 18 receptor receptor NN cord-023095-4dannjjm 2603 19 antagonist antagonist NN cord-023095-4dannjjm 2603 20 ) ) -RRB- cord-023095-4dannjjm 2603 21 , , , cord-023095-4dannjjm 2603 22 or or CC cord-023095-4dannjjm 2603 23 terbutaline terbutaline NN cord-023095-4dannjjm 2603 24 ( ( -LRB- cord-023095-4dannjjm 2603 25 b b NN cord-023095-4dannjjm 2603 26 2 2 CD cord-023095-4dannjjm 2603 27 receptor receptor NN cord-023095-4dannjjm 2603 28 agonist agonist NN cord-023095-4dannjjm 2603 29 ) ) -RRB- cord-023095-4dannjjm 2603 30 , , , cord-023095-4dannjjm 2603 31 but but CC cord-023095-4dannjjm 2603 32 were be VBD cord-023095-4dannjjm 2603 33 somewhat somewhat RB cord-023095-4dannjjm 2603 34 attenuated attenuate VBN cord-023095-4dannjjm 2603 35 by by IN cord-023095-4dannjjm 2603 36 dopamine dopamine NN cord-023095-4dannjjm 2603 37 ( ( -LRB- cord-023095-4dannjjm 2603 38 D D NNP cord-023095-4dannjjm 2603 39 2 2 CD cord-023095-4dannjjm 2603 40 receptor receptor NN cord-023095-4dannjjm 2603 41 agonist agonist NN cord-023095-4dannjjm 2603 42 ) ) -RRB- cord-023095-4dannjjm 2603 43 and and CC cord-023095-4dannjjm 2603 44 a a DT cord-023095-4dannjjm 2603 45 non non JJ cord-023095-4dannjjm 2603 46 - - JJ cord-023095-4dannjjm 2603 47 specific specific JJ cord-023095-4dannjjm 2603 48 cholinergic cholinergic JJ cord-023095-4dannjjm 2603 49 antagonist antagonist NN cord-023095-4dannjjm 2603 50 ( ( -LRB- cord-023095-4dannjjm 2603 51 atropine atropine NN cord-023095-4dannjjm 2603 52 ) ) -RRB- cord-023095-4dannjjm 2603 53 . . . cord-023095-4dannjjm 2604 1 In in IN cord-023095-4dannjjm 2604 2 vitro vitro FW cord-023095-4dannjjm 2604 3 studies study NNS cord-023095-4dannjjm 2604 4 show show VBP cord-023095-4dannjjm 2604 5 for for IN cord-023095-4dannjjm 2604 6 the the DT cord-023095-4dannjjm 2604 7 first first JJ cord-023095-4dannjjm 2604 8 time time NN cord-023095-4dannjjm 2604 9 that that IN cord-023095-4dannjjm 2604 10 domperidone domperidone NNP cord-023095-4dannjjm 2604 11 has have VBZ cord-023095-4dannjjm 2604 12 minor minor JJ cord-023095-4dannjjm 2604 13 direct direct JJ cord-023095-4dannjjm 2604 14 and and CC cord-023095-4dannjjm 2604 15 major major JJ cord-023095-4dannjjm 2604 16 indirect indirect JJ cord-023095-4dannjjm 2604 17 effects effect NNS cord-023095-4dannjjm 2604 18 in in IN cord-023095-4dannjjm 2604 19 augmenting augment VBG cord-023095-4dannjjm 2604 20 cholinergic cholinergic JJ cord-023095-4dannjjm 2604 21 contractions contraction NNS cord-023095-4dannjjm 2604 22 of of IN cord-023095-4dannjjm 2604 23 feline feline JJ cord-023095-4dannjjm 2604 24 and and CC cord-023095-4dannjjm 2604 25 rabbit rabbit NN cord-023095-4dannjjm 2604 26 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2604 27 ( ( -LRB- cord-023095-4dannjjm 2604 28 stomach stomach NN cord-023095-4dannjjm 2604 29 , , , cord-023095-4dannjjm 2604 30 cecum cecum NN cord-023095-4dannjjm 2604 31 and and CC cord-023095-4dannjjm 2604 32 colon colon NN cord-023095-4dannjjm 2604 33 ) ) -RRB- cord-023095-4dannjjm 2604 34 smooth smooth JJ cord-023095-4dannjjm 2604 35 muscle muscle NN cord-023095-4dannjjm 2604 36 . . . cord-023095-4dannjjm 2605 1 As as IN cord-023095-4dannjjm 2605 2 recognition recognition NN cord-023095-4dannjjm 2605 3 of of IN cord-023095-4dannjjm 2605 4 acute acute JJ cord-023095-4dannjjm 2605 5 and and CC cord-023095-4dannjjm 2605 6 chronic chronic JJ cord-023095-4dannjjm 2605 7 pain pain NN cord-023095-4dannjjm 2605 8 in in IN cord-023095-4dannjjm 2605 9 dogs dog NNS cord-023095-4dannjjm 2605 10 has have VBZ cord-023095-4dannjjm 2605 11 increased increase VBN cord-023095-4dannjjm 2605 12 , , , cord-023095-4dannjjm 2605 13 so so RB cord-023095-4dannjjm 2605 14 too too RB cord-023095-4dannjjm 2605 15 has have VBZ cord-023095-4dannjjm 2605 16 the the DT cord-023095-4dannjjm 2605 17 use use NN cord-023095-4dannjjm 2605 18 of of IN cord-023095-4dannjjm 2605 19 non non JJ cord-023095-4dannjjm 2605 20 - - JJ cord-023095-4dannjjm 2605 21 steroidal steroidal JJ cord-023095-4dannjjm 2605 22 anti anti JJ cord-023095-4dannjjm 2605 23 - - JJ cord-023095-4dannjjm 2605 24 inflammatory inflammatory JJ cord-023095-4dannjjm 2605 25 drugs drug NNS cord-023095-4dannjjm 2605 26 ( ( -LRB- cord-023095-4dannjjm 2605 27 NSAIDs nsaid NNS cord-023095-4dannjjm 2605 28 ) ) -RRB- cord-023095-4dannjjm 2605 29 often often RB cord-023095-4dannjjm 2605 30 in in IN cord-023095-4dannjjm 2605 31 conjunction conjunction NN cord-023095-4dannjjm 2605 32 with with IN cord-023095-4dannjjm 2605 33 tramadol tramadol NN cord-023095-4dannjjm 2605 34 . . . cord-023095-4dannjjm 2606 1 In in IN cord-023095-4dannjjm 2606 2 people people NNS cord-023095-4dannjjm 2606 3 and and CC cord-023095-4dannjjm 2606 4 rats rat NNS cord-023095-4dannjjm 2606 5 , , , cord-023095-4dannjjm 2606 6 co co NN cord-023095-4dannjjm 2606 7 - - NN cord-023095-4dannjjm 2606 8 administration administration NN cord-023095-4dannjjm 2606 9 increases increase VBZ cord-023095-4dannjjm 2606 10 the the DT cord-023095-4dannjjm 2606 11 risk risk NN cord-023095-4dannjjm 2606 12 of of IN cord-023095-4dannjjm 2606 13 perforation perforation NN cord-023095-4dannjjm 2606 14 and and CC cord-023095-4dannjjm 2606 15 gastric gastric JJ cord-023095-4dannjjm 2606 16 injury injury NN cord-023095-4dannjjm 2606 17 over over IN cord-023095-4dannjjm 2606 18 NSAIDs NSAIDs NNP cord-023095-4dannjjm 2606 19 alone alone RB cord-023095-4dannjjm 2606 20 . . . cord-023095-4dannjjm 2607 1 Using use VBG cord-023095-4dannjjm 2607 2 an an DT cord-023095-4dannjjm 2607 3 ex ex FW cord-023095-4dannjjm 2607 4 vivo vivo NN cord-023095-4dannjjm 2607 5 model model NN cord-023095-4dannjjm 2607 6 of of IN cord-023095-4dannjjm 2607 7 acid acid JJ cord-023095-4dannjjm 2607 8 injury injury NN cord-023095-4dannjjm 2607 9 in in IN cord-023095-4dannjjm 2607 10 canine canine JJ cord-023095-4dannjjm 2607 11 gastric gastric JJ cord-023095-4dannjjm 2607 12 mucosa mucosa NN cord-023095-4dannjjm 2607 13 , , , cord-023095-4dannjjm 2607 14 we -PRON- PRP cord-023095-4dannjjm 2607 15 examined examine VBD cord-023095-4dannjjm 2607 16 the the DT cord-023095-4dannjjm 2607 17 effects effect NNS cord-023095-4dannjjm 2607 18 of of IN cord-023095-4dannjjm 2607 19 indomethacin indomethacin NN cord-023095-4dannjjm 2607 20 and and CC cord-023095-4dannjjm 2607 21 tramadol tramadol NN cord-023095-4dannjjm 2607 22 on on IN cord-023095-4dannjjm 2607 23 gastric gastric JJ cord-023095-4dannjjm 2607 24 permeability permeability NN cord-023095-4dannjjm 2607 25 and and CC cord-023095-4dannjjm 2607 26 concentrations concentration NNS cord-023095-4dannjjm 2607 27 of of IN cord-023095-4dannjjm 2607 28 gastroprotective gastroprotective JJ cord-023095-4dannjjm 2607 29 prostaglandin prostaglandin NN cord-023095-4dannjjm 2607 30 E e NN cord-023095-4dannjjm 2607 31 2 2 CD cord-023095-4dannjjm 2608 1 ( ( -LRB- cord-023095-4dannjjm 2608 2 PGE PGE NNP cord-023095-4dannjjm 2608 3 2 2 CD cord-023095-4dannjjm 2608 4 ) ) -RRB- cord-023095-4dannjjm 2608 5 . . . cord-023095-4dannjjm 2609 1 Mucosa Mucosa NNP cord-023095-4dannjjm 2609 2 from from IN cord-023095-4dannjjm 2609 3 the the DT cord-023095-4dannjjm 2609 4 gastric gastric JJ cord-023095-4dannjjm 2609 5 antrum antrum NN cord-023095-4dannjjm 2609 6 was be VBD cord-023095-4dannjjm 2609 7 harvested harvest VBN cord-023095-4dannjjm 2609 8 from from IN cord-023095-4dannjjm 2609 9 5 5 CD cord-023095-4dannjjm 2609 10 shelter shelter NN cord-023095-4dannjjm 2609 11 dogs dog NNS cord-023095-4dannjjm 2609 12 immediately immediately RB cord-023095-4dannjjm 2609 13 after after IN cord-023095-4dannjjm 2609 14 euthanasia euthanasia NN cord-023095-4dannjjm 2609 15 , , , cord-023095-4dannjjm 2609 16 and and CC cord-023095-4dannjjm 2609 17 mounted mount VBD cord-023095-4dannjjm 2609 18 on on IN cord-023095-4dannjjm 2609 19 Ussing Ussing NNP cord-023095-4dannjjm 2609 20 chambers chamber NNS cord-023095-4dannjjm 2609 21 . . . cord-023095-4dannjjm 2610 1 The the DT cord-023095-4dannjjm 2610 2 tissues tissue NNS cord-023095-4dannjjm 2610 3 were be VBD cord-023095-4dannjjm 2610 4 equilibrated equilibrate VBN cord-023095-4dannjjm 2610 5 for for IN cord-023095-4dannjjm 2610 6 30-minutes 30-minute NNS cord-023095-4dannjjm 2610 7 prior prior RB cord-023095-4dannjjm 2610 8 to to IN cord-023095-4dannjjm 2610 9 addition addition NN cord-023095-4dannjjm 2610 10 of of IN cord-023095-4dannjjm 2610 11 acidic acidic JJ cord-023095-4dannjjm 2610 12 Ringer Ringer NNP cord-023095-4dannjjm 2610 13 's 's POS cord-023095-4dannjjm 2610 14 solution solution NN cord-023095-4dannjjm 2610 15 ( ( -LRB- cord-023095-4dannjjm 2610 16 pH pH NNP cord-023095-4dannjjm 2610 17 , , , cord-023095-4dannjjm 2610 18 1.2 1.2 CD cord-023095-4dannjjm 2610 19 ) ) -RRB- cord-023095-4dannjjm 2610 20 . . . cord-023095-4dannjjm 2611 1 After after IN cord-023095-4dannjjm 2611 2 45-minutes 45-minutes CD cord-023095-4dannjjm 2611 3 of of IN cord-023095-4dannjjm 2611 4 injury injury NN cord-023095-4dannjjm 2611 5 , , , cord-023095-4dannjjm 2611 6 the the DT cord-023095-4dannjjm 2611 7 acid acid NN cord-023095-4dannjjm 2611 8 was be VBD cord-023095-4dannjjm 2611 9 replaced replace VBN cord-023095-4dannjjm 2611 10 with with IN cord-023095-4dannjjm 2611 11 neutral neutral JJ cord-023095-4dannjjm 2611 12 Ringer Ringer NNP cord-023095-4dannjjm 2611 13 's 's POS cord-023095-4dannjjm 2611 14 and and CC cord-023095-4dannjjm 2611 15 the the DT cord-023095-4dannjjm 2611 16 tissues tissue NNS cord-023095-4dannjjm 2611 17 were be VBD cord-023095-4dannjjm 2611 18 treated treat VBN cord-023095-4dannjjm 2611 19 with with IN cord-023095-4dannjjm 2611 20 indomethacin indomethacin NN cord-023095-4dannjjm 2611 21 , , , cord-023095-4dannjjm 2611 22 tramadol tramadol NN cord-023095-4dannjjm 2611 23 or or CC cord-023095-4dannjjm 2611 24 both both DT cord-023095-4dannjjm 2611 25 . . . cord-023095-4dannjjm 2612 1 Tissues tissue NNS cord-023095-4dannjjm 2612 2 were be VBD cord-023095-4dannjjm 2612 3 maintained maintain VBN cord-023095-4dannjjm 2612 4 for for IN cord-023095-4dannjjm 2612 5 210minutes 210minute NNS cord-023095-4dannjjm 2612 6 total total JJ cord-023095-4dannjjm 2612 7 , , , cord-023095-4dannjjm 2612 8 during during IN cord-023095-4dannjjm 2612 9 which which WDT cord-023095-4dannjjm 2612 10 time time NN cord-023095-4dannjjm 2612 11 permeability permeability NN cord-023095-4dannjjm 2612 12 was be VBD cord-023095-4dannjjm 2612 13 assessed assess VBN cord-023095-4dannjjm 2612 14 electrically electrically RB cord-023095-4dannjjm 2612 15 . . . cord-023095-4dannjjm 2613 1 Prostanoid Prostanoid NNP cord-023095-4dannjjm 2613 2 concentrations concentration NNS cord-023095-4dannjjm 2613 3 were be VBD cord-023095-4dannjjm 2613 4 quantified quantify VBN cord-023095-4dannjjm 2613 5 using use VBG cord-023095-4dannjjm 2613 6 a a DT cord-023095-4dannjjm 2613 7 commercially commercially RB cord-023095-4dannjjm 2613 8 available available JJ cord-023095-4dannjjm 2613 9 ELISA ELISA NNP cord-023095-4dannjjm 2613 10 . . . cord-023095-4dannjjm 2614 1 Western western JJ cord-023095-4dannjjm 2614 2 blots blot NNS cord-023095-4dannjjm 2614 3 were be VBD cord-023095-4dannjjm 2614 4 performed perform VBN cord-023095-4dannjjm 2614 5 for for IN cord-023095-4dannjjm 2614 6 COX-1 COX-1 NNP cord-023095-4dannjjm 2614 7 and and CC cord-023095-4dannjjm 2614 8 À2 à2 NN cord-023095-4dannjjm 2614 9 . . . cord-023095-4dannjjm 2615 1 Recovery recovery NN cord-023095-4dannjjm 2615 2 of of IN cord-023095-4dannjjm 2615 3 gastric gastric JJ cord-023095-4dannjjm 2615 4 barrier barrier NN cord-023095-4dannjjm 2615 5 function function NN cord-023095-4dannjjm 2615 6 after after IN cord-023095-4dannjjm 2615 7 acid acid NN cord-023095-4dannjjm 2615 8 injury injury NN cord-023095-4dannjjm 2615 9 was be VBD cord-023095-4dannjjm 2615 10 inhibited inhibit VBN cord-023095-4dannjjm 2615 11 by by IN cord-023095-4dannjjm 2615 12 co co NN cord-023095-4dannjjm 2615 13 - - NN cord-023095-4dannjjm 2615 14 administration administration NN cord-023095-4dannjjm 2615 15 of of IN cord-023095-4dannjjm 2615 16 tramadol tramadol NNP cord-023095-4dannjjm 2615 17 and and CC cord-023095-4dannjjm 2615 18 indomethacin indomethacin JJ cord-023095-4dannjjm 2615 19 ( ( -LRB- cord-023095-4dannjjm 2615 20 Figure figure NN cord-023095-4dannjjm 2615 21 1 1 CD cord-023095-4dannjjm 2615 22 ) ) -RRB- cord-023095-4dannjjm 2615 23 but but CC cord-023095-4dannjjm 2615 24 not not RB cord-023095-4dannjjm 2615 25 by by IN cord-023095-4dannjjm 2615 26 tramadol tramadol NN cord-023095-4dannjjm 2615 27 or or CC cord-023095-4dannjjm 2615 28 indomethacin indomethacin NN cord-023095-4dannjjm 2615 29 alone alone RB cord-023095-4dannjjm 2615 30 ( ( -LRB- cord-023095-4dannjjm 2615 31 data datum NNS cord-023095-4dannjjm 2615 32 not not RB cord-023095-4dannjjm 2615 33 shown show VBN cord-023095-4dannjjm 2615 34 ) ) -RRB- cord-023095-4dannjjm 2615 35 . . . cord-023095-4dannjjm 2616 1 Prostaglandin prostaglandin NN cord-023095-4dannjjm 2616 2 E e NN cord-023095-4dannjjm 2616 3 2 2 NN cord-023095-4dannjjm 2616 4 increased increase VBD cord-023095-4dannjjm 2616 5 with with IN cord-023095-4dannjjm 2616 6 acid acid JJ cord-023095-4dannjjm 2616 7 injury injury NN cord-023095-4dannjjm 2616 8 . . . cord-023095-4dannjjm 2617 1 The the DT cord-023095-4dannjjm 2617 2 increase increase NN cord-023095-4dannjjm 2617 3 in in IN cord-023095-4dannjjm 2617 4 PGE PGE NNP cord-023095-4dannjjm 2617 5 2 2 CD cord-023095-4dannjjm 2617 6 was be VBD cord-023095-4dannjjm 2617 7 inhibited inhibit VBN cord-023095-4dannjjm 2617 8 by by IN cord-023095-4dannjjm 2617 9 co co NN cord-023095-4dannjjm 2617 10 - - NN cord-023095-4dannjjm 2617 11 administration administration NN cord-023095-4dannjjm 2617 12 of of IN cord-023095-4dannjjm 2617 13 indomethacin indomethacin NNP cord-023095-4dannjjm 2617 14 and and CC cord-023095-4dannjjm 2617 15 tramadol tramadol NN cord-023095-4dannjjm 2617 16 ( ( -LRB- cord-023095-4dannjjm 2617 17 in in IN cord-023095-4dannjjm 2617 18 pg pg NNP cord-023095-4dannjjm 2617 19 / / SYM cord-023095-4dannjjm 2617 20 ml ml NN cord-023095-4dannjjm 2617 21 : : : cord-023095-4dannjjm 2617 22 acid acid JJ cord-023095-4dannjjm 2617 23 injury injury NN cord-023095-4dannjjm 2617 24 681.25 681.25 CD cord-023095-4dannjjm 2617 25 AE AE NNP cord-023095-4dannjjm 2617 26 324.88 324.88 CD cord-023095-4dannjjm 2617 27 , , , cord-023095-4dannjjm 2617 28 indo indo NNP cord-023095-4dannjjm 2617 29 1 1 CD cord-023095-4dannjjm 2617 30 tramadol tramadol NN cord-023095-4dannjjm 2617 31 149.11 149.11 CD cord-023095-4dannjjm 2617 32 AE AE NNP cord-023095-4dannjjm 2617 33 35.24 35.24 CD cord-023095-4dannjjm 2617 34 ) ) -RRB- cord-023095-4dannjjm 2617 35 . . . cord-023095-4dannjjm 2618 1 There there EX cord-023095-4dannjjm 2618 2 was be VBD cord-023095-4dannjjm 2618 3 no no DT cord-023095-4dannjjm 2618 4 significant significant JJ cord-023095-4dannjjm 2618 5 effect effect NN cord-023095-4dannjjm 2618 6 of of IN cord-023095-4dannjjm 2618 7 treatment treatment NN cord-023095-4dannjjm 2618 8 on on IN cord-023095-4dannjjm 2618 9 COX-1 cox-1 JJ cord-023095-4dannjjm 2618 10 or or CC cord-023095-4dannjjm 2618 11 À2 à2 JJ cord-023095-4dannjjm 2618 12 expression expression NN cord-023095-4dannjjm 2618 13 . . . cord-023095-4dannjjm 2619 1 Co co NN cord-023095-4dannjjm 2619 2 - - NN cord-023095-4dannjjm 2619 3 administration administration NN cord-023095-4dannjjm 2619 4 of of IN cord-023095-4dannjjm 2619 5 tramadol tramadol NNP cord-023095-4dannjjm 2619 6 with with IN cord-023095-4dannjjm 2619 7 a a DT cord-023095-4dannjjm 2619 8 non non JJ cord-023095-4dannjjm 2619 9 - - JJ cord-023095-4dannjjm 2619 10 selective selective JJ cord-023095-4dannjjm 2619 11 NSAID NSAID NNP cord-023095-4dannjjm 2619 12 inhibits inhibit VBZ cord-023095-4dannjjm 2619 13 the the DT cord-023095-4dannjjm 2619 14 return return NN cord-023095-4dannjjm 2619 15 of of IN cord-023095-4dannjjm 2619 16 gastric gastric JJ cord-023095-4dannjjm 2619 17 mucosal mucosal JJ cord-023095-4dannjjm 2619 18 barrier barrier NN cord-023095-4dannjjm 2619 19 function function NN cord-023095-4dannjjm 2619 20 after after IN cord-023095-4dannjjm 2619 21 acid acid JJ cord-023095-4dannjjm 2619 22 injury injury NN cord-023095-4dannjjm 2619 23 in in IN cord-023095-4dannjjm 2619 24 canine canine JJ cord-023095-4dannjjm 2619 25 tissue tissue NN cord-023095-4dannjjm 2619 26 , , , cord-023095-4dannjjm 2619 27 suggesting suggest VBG cord-023095-4dannjjm 2619 28 that that IN cord-023095-4dannjjm 2619 29 caution caution NN cord-023095-4dannjjm 2619 30 is be VBZ cord-023095-4dannjjm 2619 31 required require VBN cord-023095-4dannjjm 2619 32 in in IN cord-023095-4dannjjm 2619 33 prescribing prescribe VBG cord-023095-4dannjjm 2619 34 concurrent concurrent JJ cord-023095-4dannjjm 2619 35 use use NN cord-023095-4dannjjm 2619 36 of of IN cord-023095-4dannjjm 2619 37 these these DT cord-023095-4dannjjm 2619 38 drugs drug NNS cord-023095-4dannjjm 2619 39 in in IN cord-023095-4dannjjm 2619 40 dogs dog NNS cord-023095-4dannjjm 2619 41 at at IN cord-023095-4dannjjm 2619 42 risk risk NN cord-023095-4dannjjm 2619 43 for for IN cord-023095-4dannjjm 2619 44 gastric gastric JJ cord-023095-4dannjjm 2619 45 ulcers ulcer NNS cord-023095-4dannjjm 2619 46 . . . cord-023095-4dannjjm 2620 1 These these DT cord-023095-4dannjjm 2620 2 drugs drug NNS cord-023095-4dannjjm 2620 3 may may MD cord-023095-4dannjjm 2620 4 exert exert VB cord-023095-4dannjjm 2620 5 this this DT cord-023095-4dannjjm 2620 6 effect effect NN cord-023095-4dannjjm 2620 7 by by IN cord-023095-4dannjjm 2620 8 decreasing decrease VBG cord-023095-4dannjjm 2620 9 levels level NNS cord-023095-4dannjjm 2620 10 of of IN cord-023095-4dannjjm 2620 11 gastroprotective gastroprotective JJ cord-023095-4dannjjm 2620 12 prostanoids prostanoid NNS cord-023095-4dannjjm 2620 13 . . . cord-023095-4dannjjm 2621 1 Further further JJ cord-023095-4dannjjm 2621 2 study study NN cord-023095-4dannjjm 2621 3 is be VBZ cord-023095-4dannjjm 2621 4 needed need VBN cord-023095-4dannjjm 2621 5 to to TO cord-023095-4dannjjm 2621 6 understand understand VB cord-023095-4dannjjm 2621 7 the the DT cord-023095-4dannjjm 2621 8 mechanism mechanism NN cord-023095-4dannjjm 2621 9 of of IN cord-023095-4dannjjm 2621 10 this this DT cord-023095-4dannjjm 2621 11 drug drug NN cord-023095-4dannjjm 2621 12 interaction interaction NN cord-023095-4dannjjm 2621 13 . . . cord-023095-4dannjjm 2622 1 An an DT cord-023095-4dannjjm 2622 2 increased increase VBN cord-023095-4dannjjm 2622 3 intestinal intestinal JJ cord-023095-4dannjjm 2622 4 permeability permeability NN cord-023095-4dannjjm 2622 5 ( ( -LRB- cord-023095-4dannjjm 2622 6 IP IP NNP cord-023095-4dannjjm 2622 7 ) ) -RRB- cord-023095-4dannjjm 2622 8 has have VBZ cord-023095-4dannjjm 2622 9 been be VBN cord-023095-4dannjjm 2622 10 suggested suggest VBN cord-023095-4dannjjm 2622 11 to to TO cord-023095-4dannjjm 2622 12 be be VB cord-023095-4dannjjm 2622 13 both both DT cord-023095-4dannjjm 2622 14 cause cause VB cord-023095-4dannjjm 2622 15 and and CC cord-023095-4dannjjm 2622 16 consequence consequence NN cord-023095-4dannjjm 2622 17 of of IN cord-023095-4dannjjm 2622 18 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2622 19 ( ( -LRB- cord-023095-4dannjjm 2622 20 GI GI NNP cord-023095-4dannjjm 2622 21 ) ) -RRB- cord-023095-4dannjjm 2622 22 disease disease NN cord-023095-4dannjjm 2622 23 , , , cord-023095-4dannjjm 2622 24 such such JJ cord-023095-4dannjjm 2622 25 as as IN cord-023095-4dannjjm 2622 26 inflammatory inflammatory JJ cord-023095-4dannjjm 2622 27 bowel bowel NN cord-023095-4dannjjm 2622 28 and and CC cord-023095-4dannjjm 2622 29 celiac celiac JJ cord-023095-4dannjjm 2622 30 disease disease NN cord-023095-4dannjjm 2622 31 , , , cord-023095-4dannjjm 2622 32 in in IN cord-023095-4dannjjm 2622 33 people people NNS cord-023095-4dannjjm 2622 34 . . . cord-023095-4dannjjm 2623 1 A a DT cord-023095-4dannjjm 2623 2 novel novel JJ cord-023095-4dannjjm 2623 3 tight tight JJ cord-023095-4dannjjm 2623 4 junction junction NN cord-023095-4dannjjm 2623 5 regulator regulator NN cord-023095-4dannjjm 2623 6 , , , cord-023095-4dannjjm 2623 7 larazotide larazotide NN cord-023095-4dannjjm 2623 8 acetate acetate NN cord-023095-4dannjjm 2623 9 ( ( -LRB- cord-023095-4dannjjm 2623 10 Alba Alba NNP cord-023095-4dannjjm 2623 11 Therapeutics Therapeutics NNP cord-023095-4dannjjm 2623 12 , , , cord-023095-4dannjjm 2623 13 Baltimore Baltimore NNP cord-023095-4dannjjm 2623 14 , , , cord-023095-4dannjjm 2623 15 MD MD NNP cord-023095-4dannjjm 2623 16 ) ) -RRB- cord-023095-4dannjjm 2623 17 has have VBZ cord-023095-4dannjjm 2623 18 been be VBN cord-023095-4dannjjm 2623 19 shown show VBN cord-023095-4dannjjm 2623 20 to to TO cord-023095-4dannjjm 2623 21 significantly significantly RB cord-023095-4dannjjm 2623 22 decrease decrease VB cord-023095-4dannjjm 2623 23 IP ip NN cord-023095-4dannjjm 2623 24 in in IN cord-023095-4dannjjm 2623 25 rats rat NNS cord-023095-4dannjjm 2623 26 and and CC cord-023095-4dannjjm 2623 27 in in IN cord-023095-4dannjjm 2623 28 humans human NNS cord-023095-4dannjjm 2623 29 with with IN cord-023095-4dannjjm 2623 30 celiac celiac JJ cord-023095-4dannjjm 2623 31 disease disease NN cord-023095-4dannjjm 2623 32 . . . cord-023095-4dannjjm 2624 1 The the DT cord-023095-4dannjjm 2624 2 purpose purpose NN cord-023095-4dannjjm 2624 3 of of IN cord-023095-4dannjjm 2624 4 this this DT cord-023095-4dannjjm 2624 5 study study NN cord-023095-4dannjjm 2624 6 was be VBD cord-023095-4dannjjm 2624 7 to to TO cord-023095-4dannjjm 2624 8 determine determine VB cord-023095-4dannjjm 2624 9 if if IN cord-023095-4dannjjm 2624 10 larazotide larazotide NN cord-023095-4dannjjm 2624 11 acetate acetate NN cord-023095-4dannjjm 2624 12 reduces reduce VBZ cord-023095-4dannjjm 2624 13 IP ip NN cord-023095-4dannjjm 2624 14 in in IN cord-023095-4dannjjm 2624 15 Soft Soft NNP cord-023095-4dannjjm 2624 16 Coated Coated NNP cord-023095-4dannjjm 2624 17 Wheaten Wheaten NNP cord-023095-4dannjjm 2624 18 Terriers Terriers NNPS cord-023095-4dannjjm 2624 19 ( ( -LRB- cord-023095-4dannjjm 2624 20 SCWT SCWT NNP cord-023095-4dannjjm 2624 21 ) ) -RRB- cord-023095-4dannjjm 2624 22 and and CC cord-023095-4dannjjm 2624 23 Norwegian Norwegian NNP cord-023095-4dannjjm 2624 24 Lundehunds Lundehunds NNPS cord-023095-4dannjjm 2624 25 ( ( -LRB- cord-023095-4dannjjm 2624 26 NL NL NNP cord-023095-4dannjjm 2624 27 ) ) -RRB- cord-023095-4dannjjm 2624 28 with with IN cord-023095-4dannjjm 2624 29 chronic chronic JJ cord-023095-4dannjjm 2624 30 GI GI NNP cord-023095-4dannjjm 2624 31 disease disease NN cord-023095-4dannjjm 2624 32 and and CC cord-023095-4dannjjm 2624 33 ameliorates ameliorate VBZ cord-023095-4dannjjm 2624 34 clinical clinical JJ cord-023095-4dannjjm 2624 35 signs sign NNS cord-023095-4dannjjm 2624 36 . . . cord-023095-4dannjjm 2625 1 Four four CD cord-023095-4dannjjm 2625 2 NL NL NNP cord-023095-4dannjjm 2625 3 ( ( -LRB- cord-023095-4dannjjm 2625 4 2 2 CD cord-023095-4dannjjm 2625 5 females female NNS cord-023095-4dannjjm 2625 6 , , , cord-023095-4dannjjm 2625 7 2 2 CD cord-023095-4dannjjm 2625 8 males male NNS cord-023095-4dannjjm 2625 9 ; ; : cord-023095-4dannjjm 2625 10 median median JJ cord-023095-4dannjjm 2625 11 age age NN cord-023095-4dannjjm 2625 12 : : : cord-023095-4dannjjm 2625 13 2.5 2.5 CD cord-023095-4dannjjm 2625 14 yrs yr NNS cord-023095-4dannjjm 2625 15 , , , cord-023095-4dannjjm 2625 16 range range NN cord-023095-4dannjjm 2625 17 : : : cord-023095-4dannjjm 2625 18 1.5 1.5 CD cord-023095-4dannjjm 2625 19 - - SYM cord-023095-4dannjjm 2625 20 4.5 4.5 CD cord-023095-4dannjjm 2625 21 yrs yr NNS cord-023095-4dannjjm 2625 22 ) ) -RRB- cord-023095-4dannjjm 2625 23 and and CC cord-023095-4dannjjm 2625 24 9 9 CD cord-023095-4dannjjm 2625 25 SCWT SCWT NNP cord-023095-4dannjjm 2625 26 ( ( -LRB- cord-023095-4dannjjm 2625 27 7 7 CD cord-023095-4dannjjm 2625 28 females female NNS cord-023095-4dannjjm 2625 29 , , , cord-023095-4dannjjm 2625 30 2 2 CD cord-023095-4dannjjm 2625 31 males male NNS cord-023095-4dannjjm 2625 32 ; ; : cord-023095-4dannjjm 2625 33 median median JJ cord-023095-4dannjjm 2625 34 age age NN cord-023095-4dannjjm 2625 35 : : : cord-023095-4dannjjm 2625 36 5.0 5.0 CD cord-023095-4dannjjm 2625 37 yrs yr NNS cord-023095-4dannjjm 2625 38 , , , cord-023095-4dannjjm 2625 39 range range NN cord-023095-4dannjjm 2625 40 : : : cord-023095-4dannjjm 2625 41 1.5 1.5 CD cord-023095-4dannjjm 2625 42 - - SYM cord-023095-4dannjjm 2625 43 9.0 9.0 CD cord-023095-4dannjjm 2625 44 yrs yr NNS cord-023095-4dannjjm 2625 45 ) ) -RRB- cord-023095-4dannjjm 2625 46 were be VBD cord-023095-4dannjjm 2625 47 enrolled enrol VBN cord-023095-4dannjjm 2625 48 based base VBN cord-023095-4dannjjm 2625 49 on on IN cord-023095-4dannjjm 2625 50 presence presence NN cord-023095-4dannjjm 2625 51 of of IN cord-023095-4dannjjm 2625 52 clinical clinical JJ cord-023095-4dannjjm 2625 53 signs sign NNS cord-023095-4dannjjm 2625 54 of of IN cord-023095-4dannjjm 2625 55 GI GI NNP cord-023095-4dannjjm 2625 56 disease disease NN cord-023095-4dannjjm 2625 57 and and CC cord-023095-4dannjjm 2625 58 hypoalbuminemia hypoalbuminemia NN cord-023095-4dannjjm 2625 59 , , , cord-023095-4dannjjm 2625 60 increased increase VBD cord-023095-4dannjjm 2625 61 fecal fecal JJ cord-023095-4dannjjm 2625 62 alpha alpha NN cord-023095-4dannjjm 2625 63 1proteinase 1proteinase CD cord-023095-4dannjjm 2625 64 inhibitor inhibitor NN cord-023095-4dannjjm 2625 65 ( ( -LRB- cord-023095-4dannjjm 2625 66 a a DT cord-023095-4dannjjm 2625 67 1 1 CD cord-023095-4dannjjm 2625 68 -PI -PI NNS cord-023095-4dannjjm 2625 69 ) ) -RRB- cord-023095-4dannjjm 2625 70 concentrations concentration NNS cord-023095-4dannjjm 2625 71 , , , cord-023095-4dannjjm 2625 72 and/or and/or CC cord-023095-4dannjjm 2625 73 hypocobalaminemia hypocobalaminemia NN cord-023095-4dannjjm 2625 74 . . . cord-023095-4dannjjm 2626 1 SCWT SCWT NNP cord-023095-4dannjjm 2626 2 with with IN cord-023095-4dannjjm 2626 3 protein protein NN cord-023095-4dannjjm 2626 4 - - HYPH cord-023095-4dannjjm 2626 5 losing lose VBG cord-023095-4dannjjm 2626 6 nephropathy nephropathy NN cord-023095-4dannjjm 2626 7 were be VBD cord-023095-4dannjjm 2626 8 excluded exclude VBN cord-023095-4dannjjm 2626 9 . . . cord-023095-4dannjjm 2627 1 Dogs dog NNS cord-023095-4dannjjm 2627 2 were be VBD cord-023095-4dannjjm 2627 3 fed feed VBN cord-023095-4dannjjm 2627 4 q12 q12 NN cord-023095-4dannjjm 2627 5 hrs hrs NN cord-023095-4dannjjm 2627 6 and and CC cord-023095-4dannjjm 2627 7 received receive VBD cord-023095-4dannjjm 2627 8 0.5 0.5 CD cord-023095-4dannjjm 2627 9 mg mg NN cord-023095-4dannjjm 2627 10 ( ( -LRB- cord-023095-4dannjjm 2627 11 4 4 CD cord-023095-4dannjjm 2627 12 NL NL NNP cord-023095-4dannjjm 2627 13 and and CC cord-023095-4dannjjm 2627 14 2 2 CD cord-023095-4dannjjm 2627 15 SCWT SCWT NNP cord-023095-4dannjjm 2627 16 ) ) -RRB- cord-023095-4dannjjm 2627 17 or or CC cord-023095-4dannjjm 2627 18 2.0 2.0 CD cord-023095-4dannjjm 2627 19 mg mg NN cord-023095-4dannjjm 2627 20 ( ( -LRB- cord-023095-4dannjjm 2627 21 7 7 CD cord-023095-4dannjjm 2627 22 SCWT SCWT NNP cord-023095-4dannjjm 2627 23 ) ) -RRB- cord-023095-4dannjjm 2627 24 of of IN cord-023095-4dannjjm 2627 25 larazotide larazotide NN cord-023095-4dannjjm 2627 26 acetate acetate NN cord-023095-4dannjjm 2627 27 PO PO NNP cord-023095-4dannjjm 2627 28 before before IN cord-023095-4dannjjm 2627 29 each each DT cord-023095-4dannjjm 2627 30 meal meal NN cord-023095-4dannjjm 2627 31 for for IN cord-023095-4dannjjm 2627 32 90 90 CD cord-023095-4dannjjm 2627 33 days day NNS cord-023095-4dannjjm 2627 34 . . . cord-023095-4dannjjm 2628 1 Prior prior RB cord-023095-4dannjjm 2628 2 to to TO cord-023095-4dannjjm 2628 3 start start VB cord-023095-4dannjjm 2628 4 of of IN cord-023095-4dannjjm 2628 5 treatment treatment NN cord-023095-4dannjjm 2628 6 ( ( -LRB- cord-023095-4dannjjm 2628 7 day day NN cord-023095-4dannjjm 2628 8 1 1 CD cord-023095-4dannjjm 2628 9 ) ) -RRB- cord-023095-4dannjjm 2628 10 and and CC cord-023095-4dannjjm 2628 11 at at IN cord-023095-4dannjjm 2628 12 the the DT cord-023095-4dannjjm 2628 13 end end NN cord-023095-4dannjjm 2628 14 ( ( -LRB- cord-023095-4dannjjm 2628 15 day day NN cord-023095-4dannjjm 2628 16 90 90 CD cord-023095-4dannjjm 2628 17 ) ) -RRB- cord-023095-4dannjjm 2628 18 , , , cord-023095-4dannjjm 2628 19 IP IP NNP cord-023095-4dannjjm 2628 20 was be VBD cord-023095-4dannjjm 2628 21 evaluated evaluate VBN cord-023095-4dannjjm 2628 22 by by IN cord-023095-4dannjjm 2628 23 calculating calculate VBG cord-023095-4dannjjm 2628 24 the the DT cord-023095-4dannjjm 2628 25 lactulose lactulose NN cord-023095-4dannjjm 2628 26 / / SYM cord-023095-4dannjjm 2628 27 rhamnose rhamnose NNP cord-023095-4dannjjm 2628 28 ( ( -LRB- cord-023095-4dannjjm 2628 29 L L NNP cord-023095-4dannjjm 2628 30 / / SYM cord-023095-4dannjjm 2628 31 R)-ratio R)-ratio NNP cord-023095-4dannjjm 2628 32 in in IN cord-023095-4dannjjm 2628 33 serum serum NN cord-023095-4dannjjm 2628 34 samples sample NNS cord-023095-4dannjjm 2628 35 obtained obtain VBN cord-023095-4dannjjm 2628 36 at at IN cord-023095-4dannjjm 2628 37 30 30 CD cord-023095-4dannjjm 2628 38 , , , cord-023095-4dannjjm 2628 39 60 60 CD cord-023095-4dannjjm 2628 40 , , , cord-023095-4dannjjm 2628 41 90 90 CD cord-023095-4dannjjm 2628 42 , , , cord-023095-4dannjjm 2628 43 and and CC cord-023095-4dannjjm 2628 44 120 120 CD cord-023095-4dannjjm 2628 45 min min NNS cord-023095-4dannjjm 2628 46 after after IN cord-023095-4dannjjm 2628 47 oral oral JJ cord-023095-4dannjjm 2628 48 dosing dosing NN cord-023095-4dannjjm 2628 49 . . . cord-023095-4dannjjm 2629 1 Also also RB cord-023095-4dannjjm 2629 2 , , , cord-023095-4dannjjm 2629 3 3 3 CD cord-023095-4dannjjm 2629 4 consecutive consecutive JJ cord-023095-4dannjjm 2629 5 fecal fecal JJ cord-023095-4dannjjm 2629 6 samples sample NNS cord-023095-4dannjjm 2629 7 each each DT cord-023095-4dannjjm 2629 8 were be VBD cord-023095-4dannjjm 2629 9 collected collect VBN cord-023095-4dannjjm 2629 10 prior prior RB cord-023095-4dannjjm 2629 11 to to IN cord-023095-4dannjjm 2629 12 day day NN cord-023095-4dannjjm 2629 13 1 1 CD cord-023095-4dannjjm 2629 14 and and CC cord-023095-4dannjjm 2629 15 day day NN cord-023095-4dannjjm 2629 16 90 90 CD cord-023095-4dannjjm 2629 17 for for IN cord-023095-4dannjjm 2629 18 N n CD cord-023095-4dannjjm 2629 19 - - HYPH cord-023095-4dannjjm 2629 20 methylhistamine methylhistamine NNP cord-023095-4dannjjm 2629 21 ( ( -LRB- cord-023095-4dannjjm 2629 22 NMH NMH NNP cord-023095-4dannjjm 2629 23 ) ) -RRB- cord-023095-4dannjjm 2629 24 measurement measurement NN cord-023095-4dannjjm 2629 25 . . . cord-023095-4dannjjm 2630 1 Pre pre JJ cord-023095-4dannjjm 2630 2 - - JJ cord-023095-4dannjjm 2630 3 and and CC cord-023095-4dannjjm 2630 4 post post JJ cord-023095-4dannjjm 2630 5 - - JJ cord-023095-4dannjjm 2630 6 treatment treatment JJ cord-023095-4dannjjm 2630 7 data datum NNS cord-023095-4dannjjm 2630 8 were be VBD cord-023095-4dannjjm 2630 9 compared compare VBN cord-023095-4dannjjm 2630 10 using use VBG cord-023095-4dannjjm 2630 11 a a DT cord-023095-4dannjjm 2630 12 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 2630 13 signed sign VBN cord-023095-4dannjjm 2630 14 rank rank NN cord-023095-4dannjjm 2630 15 test test NN cord-023095-4dannjjm 2630 16 . . . cord-023095-4dannjjm 2631 1 The the DT cord-023095-4dannjjm 2631 2 0.5 0.5 CD cord-023095-4dannjjm 2631 3 mg mg NN cord-023095-4dannjjm 2631 4 vs. vs. IN cord-023095-4dannjjm 2631 5 2.0 2.0 CD cord-023095-4dannjjm 2631 6 mg mg NN cord-023095-4dannjjm 2631 7 dose dose NN cord-023095-4dannjjm 2631 8 groups group NNS cord-023095-4dannjjm 2631 9 were be VBD cord-023095-4dannjjm 2631 10 compared compare VBN cord-023095-4dannjjm 2631 11 using use VBG cord-023095-4dannjjm 2631 12 a a DT cord-023095-4dannjjm 2631 13 Mann Mann NNP cord-023095-4dannjjm 2631 14 - - HYPH cord-023095-4dannjjm 2631 15 Whitney Whitney NNP cord-023095-4dannjjm 2631 16 U U NNP cord-023095-4dannjjm 2631 17 test test NN cord-023095-4dannjjm 2631 18 . . . cord-023095-4dannjjm 2632 1 Statistical statistical JJ cord-023095-4dannjjm 2632 2 significance significance NN cord-023095-4dannjjm 2632 3 was be VBD cord-023095-4dannjjm 2632 4 set set VBN cord-023095-4dannjjm 2632 5 at at IN cord-023095-4dannjjm 2632 6 p p NN cord-023095-4dannjjm 2632 7 o o NN cord-023095-4dannjjm 2632 8 0.05 0.05 CD cord-023095-4dannjjm 2632 9 . . . cord-023095-4dannjjm 2633 1 L L NNP cord-023095-4dannjjm 2633 2 / / SYM cord-023095-4dannjjm 2633 3 R r NN cord-023095-4dannjjm 2633 4 - - HYPH cord-023095-4dannjjm 2633 5 ratios ratio NNS cord-023095-4dannjjm 2633 6 ( ( -LRB- cord-023095-4dannjjm 2633 7 medians median NNS cord-023095-4dannjjm 2633 8 ) ) -RRB- cord-023095-4dannjjm 2633 9 for for IN cord-023095-4dannjjm 2633 10 the the DT cord-023095-4dannjjm 2633 11 60 60 CD cord-023095-4dannjjm 2633 12 min min NN cord-023095-4dannjjm 2633 13 sampling sampling NN cord-023095-4dannjjm 2633 14 time time NN cord-023095-4dannjjm 2633 15 point point NN cord-023095-4dannjjm 2633 16 were be VBD cord-023095-4dannjjm 2633 17 significantly significantly RB cord-023095-4dannjjm 2633 18 lower low JJR cord-023095-4dannjjm 2633 19 on on IN cord-023095-4dannjjm 2633 20 day day NN cord-023095-4dannjjm 2633 21 90 90 CD cord-023095-4dannjjm 2633 22 ( ( -LRB- cord-023095-4dannjjm 2633 23 0.046 0.046 CD cord-023095-4dannjjm 2633 24 ) ) -RRB- cord-023095-4dannjjm 2633 25 than than IN cord-023095-4dannjjm 2633 26 on on IN cord-023095-4dannjjm 2633 27 day day NN cord-023095-4dannjjm 2633 28 1 1 CD cord-023095-4dannjjm 2633 29 ( ( -LRB- cord-023095-4dannjjm 2633 30 0.080 0.080 CD cord-023095-4dannjjm 2633 31 ; ; : cord-023095-4dannjjm 2633 32 p p NN cord-023095-4dannjjm 2633 33 5 5 CD cord-023095-4dannjjm 2633 34 0.018 0.018 CD cord-023095-4dannjjm 2633 35 ) ) -RRB- cord-023095-4dannjjm 2633 36 . . . cord-023095-4dannjjm 2634 1 Dogs dog NNS cord-023095-4dannjjm 2634 2 treated treat VBN cord-023095-4dannjjm 2634 3 with with IN cord-023095-4dannjjm 2634 4 2.0 2.0 CD cord-023095-4dannjjm 2634 5 mg mg NN cord-023095-4dannjjm 2635 1 q12 q12 NNP cord-023095-4dannjjm 2635 2 hrs hrs NNP cord-023095-4dannjjm 2635 3 had have VBD cord-023095-4dannjjm 2635 4 significantly significantly RB cord-023095-4dannjjm 2635 5 lower low JJR cord-023095-4dannjjm 2635 6 60 60 CD cord-023095-4dannjjm 2635 7 min min NN cord-023095-4dannjjm 2635 8 L l NN cord-023095-4dannjjm 2635 9 / / SYM cord-023095-4dannjjm 2635 10 R r NN cord-023095-4dannjjm 2635 11 ratios ratio NNS cord-023095-4dannjjm 2635 12 on on IN cord-023095-4dannjjm 2635 13 day day NN cord-023095-4dannjjm 2635 14 90 90 CD cord-023095-4dannjjm 2635 15 than than IN cord-023095-4dannjjm 2635 16 dogs dog NNS cord-023095-4dannjjm 2635 17 treated treat VBN cord-023095-4dannjjm 2635 18 with with IN cord-023095-4dannjjm 2635 19 0.5 0.5 CD cord-023095-4dannjjm 2635 20 mg mg NNP cord-023095-4dannjjm 2635 21 ( ( -LRB- cord-023095-4dannjjm 2635 22 0.033 0.033 CD cord-023095-4dannjjm 2635 23 vs. vs. FW cord-023095-4dannjjm 2635 24 0.094 0.094 CD cord-023095-4dannjjm 2635 25 ; ; : cord-023095-4dannjjm 2635 26 p p NN cord-023095-4dannjjm 2635 27 5 5 CD cord-023095-4dannjjm 2635 28 0.014 0.014 CD cord-023095-4dannjjm 2635 29 ) ) -RRB- cord-023095-4dannjjm 2635 30 . . . cord-023095-4dannjjm 2636 1 No no DT cord-023095-4dannjjm 2636 2 difference difference NN cord-023095-4dannjjm 2636 3 was be VBD cord-023095-4dannjjm 2636 4 found find VBN cord-023095-4dannjjm 2636 5 between between IN cord-023095-4dannjjm 2636 6 breeds breed NNS cord-023095-4dannjjm 2636 7 . . . cord-023095-4dannjjm 2637 1 Fecal fecal JJ cord-023095-4dannjjm 2637 2 NMH NMH NNP cord-023095-4dannjjm 2637 3 concentrations concentration NNS cord-023095-4dannjjm 2637 4 were be VBD cord-023095-4dannjjm 2637 5 not not RB cord-023095-4dannjjm 2637 6 different different JJ cord-023095-4dannjjm 2637 7 between between IN cord-023095-4dannjjm 2637 8 time time NN cord-023095-4dannjjm 2637 9 points point NNS cord-023095-4dannjjm 2637 10 , , , cord-023095-4dannjjm 2637 11 treatment treatment NN cord-023095-4dannjjm 2637 12 groups group NNS cord-023095-4dannjjm 2637 13 , , , cord-023095-4dannjjm 2637 14 or or CC cord-023095-4dannjjm 2637 15 breeds breed NNS cord-023095-4dannjjm 2637 16 . . . cord-023095-4dannjjm 2638 1 Fecal Fecal NNP cord-023095-4dannjjm 2638 2 a a DT cord-023095-4dannjjm 2638 3 1 1 CD cord-023095-4dannjjm 2638 4 -PI -pi NN cord-023095-4dannjjm 2638 5 concentrations concentration NNS cord-023095-4dannjjm 2638 6 were be VBD cord-023095-4dannjjm 2638 7 available available JJ cord-023095-4dannjjm 2638 8 for for IN cord-023095-4dannjjm 2638 9 11 11 CD cord-023095-4dannjjm 2638 10 of of IN cord-023095-4dannjjm 2638 11 the the DT cord-023095-4dannjjm 2638 12 13 13 CD cord-023095-4dannjjm 2638 13 dogs dog NNS cord-023095-4dannjjm 2638 14 and and CC cord-023095-4dannjjm 2638 15 were be VBD cord-023095-4dannjjm 2638 16 significantly significantly RB cord-023095-4dannjjm 2638 17 higher high JJR cord-023095-4dannjjm 2638 18 on on IN cord-023095-4dannjjm 2638 19 day day NN cord-023095-4dannjjm 2638 20 90 90 CD cord-023095-4dannjjm 2638 21 compared compare VBN cord-023095-4dannjjm 2638 22 to to IN cord-023095-4dannjjm 2638 23 day day NN cord-023095-4dannjjm 2638 24 1 1 CD cord-023095-4dannjjm 2639 1 ( ( -LRB- cord-023095-4dannjjm 2639 2 p p NN cord-023095-4dannjjm 2639 3 5 5 CD cord-023095-4dannjjm 2639 4 0.033 0.033 CD cord-023095-4dannjjm 2639 5 ) ) -RRB- cord-023095-4dannjjm 2639 6 . . . cord-023095-4dannjjm 2640 1 No no DT cord-023095-4dannjjm 2640 2 differences difference NNS cord-023095-4dannjjm 2640 3 were be VBD cord-023095-4dannjjm 2640 4 found find VBN cord-023095-4dannjjm 2640 5 between between IN cord-023095-4dannjjm 2640 6 pre pre JJ cord-023095-4dannjjm 2640 7 - - JJ cord-023095-4dannjjm 2640 8 and and CC cord-023095-4dannjjm 2640 9 post post JJ cord-023095-4dannjjm 2640 10 - - JJ cord-023095-4dannjjm 2640 11 treatment treatment JJ cord-023095-4dannjjm 2640 12 serum serum NN cord-023095-4dannjjm 2640 13 albumin albumin NN cord-023095-4dannjjm 2640 14 or or CC cord-023095-4dannjjm 2640 15 cobalamin cobalamin NN cord-023095-4dannjjm 2640 16 concentrations concentration NNS cord-023095-4dannjjm 2640 17 . . . cord-023095-4dannjjm 2641 1 Weight weight NN cord-023095-4dannjjm 2641 2 gain gain NN cord-023095-4dannjjm 2641 3 was be VBD cord-023095-4dannjjm 2641 4 seen see VBN cord-023095-4dannjjm 2641 5 in in IN cord-023095-4dannjjm 2641 6 all all DT cord-023095-4dannjjm 2641 7 4 4 CD cord-023095-4dannjjm 2641 8 NL NL NNP cord-023095-4dannjjm 2641 9 . . . cord-023095-4dannjjm 2642 1 Resolution resolution NN cord-023095-4dannjjm 2642 2 of of IN cord-023095-4dannjjm 2642 3 diarrhea diarrhea NN cord-023095-4dannjjm 2642 4 , , , cord-023095-4dannjjm 2642 5 vomiting vomit VBG cord-023095-4dannjjm 2642 6 , , , cord-023095-4dannjjm 2642 7 hyporexia hyporexia NNP cord-023095-4dannjjm 2642 8 , , , cord-023095-4dannjjm 2642 9 as as RB cord-023095-4dannjjm 2642 10 well well RB cord-023095-4dannjjm 2642 11 as as IN cord-023095-4dannjjm 2642 12 an an DT cord-023095-4dannjjm 2642 13 increased increase VBN cord-023095-4dannjjm 2642 14 activity activity NN cord-023095-4dannjjm 2642 15 was be VBD cord-023095-4dannjjm 2642 16 seen see VBN cord-023095-4dannjjm 2642 17 in in IN cord-023095-4dannjjm 2642 18 1 1 CD cord-023095-4dannjjm 2642 19 SCWT SCWT NNP cord-023095-4dannjjm 2642 20 . . . cord-023095-4dannjjm 2643 1 Another another DT cord-023095-4dannjjm 2643 2 SCWT SCWT NNP cord-023095-4dannjjm 2643 3 had have VBD cord-023095-4dannjjm 2643 4 resolution resolution NN cord-023095-4dannjjm 2643 5 of of IN cord-023095-4dannjjm 2643 6 diarrhea diarrhea NN cord-023095-4dannjjm 2643 7 and and CC cord-023095-4dannjjm 2643 8 a a DT cord-023095-4dannjjm 2643 9 decrease decrease NN cord-023095-4dannjjm 2643 10 in in IN cord-023095-4dannjjm 2643 11 pruritus pruritus NN cord-023095-4dannjjm 2643 12 . . . cord-023095-4dannjjm 2644 1 No no DT cord-023095-4dannjjm 2644 2 changes change NNS cord-023095-4dannjjm 2644 3 in in IN cord-023095-4dannjjm 2644 4 clinical clinical JJ cord-023095-4dannjjm 2644 5 signs sign NNS cord-023095-4dannjjm 2644 6 were be VBD cord-023095-4dannjjm 2644 7 reported report VBN cord-023095-4dannjjm 2644 8 in in IN cord-023095-4dannjjm 2644 9 the the DT cord-023095-4dannjjm 2644 10 remaining remain VBG cord-023095-4dannjjm 2644 11 7 7 CD cord-023095-4dannjjm 2644 12 SCWT SCWT NNP cord-023095-4dannjjm 2644 13 . . . cord-023095-4dannjjm 2645 1 This this DT cord-023095-4dannjjm 2645 2 study study NN cord-023095-4dannjjm 2645 3 indicates indicate VBZ cord-023095-4dannjjm 2645 4 that that IN cord-023095-4dannjjm 2645 5 larazotide larazotide NN cord-023095-4dannjjm 2645 6 acetate acetate NN cord-023095-4dannjjm 2645 7 might may MD cord-023095-4dannjjm 2645 8 be be VB cord-023095-4dannjjm 2645 9 able able JJ cord-023095-4dannjjm 2645 10 to to TO cord-023095-4dannjjm 2645 11 reduce reduce VB cord-023095-4dannjjm 2645 12 IP ip NN cord-023095-4dannjjm 2645 13 in in IN cord-023095-4dannjjm 2645 14 dogs dog NNS cord-023095-4dannjjm 2645 15 . . . cord-023095-4dannjjm 2646 1 This this DT cord-023095-4dannjjm 2646 2 effect effect NN cord-023095-4dannjjm 2646 3 may may MD cord-023095-4dannjjm 2646 4 be be VB cord-023095-4dannjjm 2646 5 dose dose NN cord-023095-4dannjjm 2646 6 - - HYPH cord-023095-4dannjjm 2646 7 dependent dependent JJ cord-023095-4dannjjm 2646 8 . . . cord-023095-4dannjjm 2647 1 However however RB cord-023095-4dannjjm 2647 2 , , , cord-023095-4dannjjm 2647 3 not not RB cord-023095-4dannjjm 2647 4 all all DT cord-023095-4dannjjm 2647 5 dogs dog NNS cord-023095-4dannjjm 2647 6 showed show VBD cord-023095-4dannjjm 2647 7 an an DT cord-023095-4dannjjm 2647 8 improvement improvement NN cord-023095-4dannjjm 2647 9 in in IN cord-023095-4dannjjm 2647 10 clinical clinical JJ cord-023095-4dannjjm 2647 11 signs sign NNS cord-023095-4dannjjm 2647 12 , , , cord-023095-4dannjjm 2647 13 suggesting suggest VBG cord-023095-4dannjjm 2647 14 that that IN cord-023095-4dannjjm 2647 15 factors factor NNS cord-023095-4dannjjm 2647 16 other other JJ cord-023095-4dannjjm 2647 17 than than IN cord-023095-4dannjjm 2647 18 increased increase VBN cord-023095-4dannjjm 2647 19 IP IP NNP cord-023095-4dannjjm 2647 20 might may MD cord-023095-4dannjjm 2647 21 have have VB cord-023095-4dannjjm 2647 22 been be VBN cord-023095-4dannjjm 2647 23 responsible responsible JJ cord-023095-4dannjjm 2647 24 for for IN cord-023095-4dannjjm 2647 25 the the DT cord-023095-4dannjjm 2647 26 clinical clinical JJ cord-023095-4dannjjm 2647 27 signs sign NNS cord-023095-4dannjjm 2647 28 in in IN cord-023095-4dannjjm 2647 29 these these DT cord-023095-4dannjjm 2647 30 dogs dog NNS cord-023095-4dannjjm 2647 31 . . . cord-023095-4dannjjm 2648 1 Breed breed VB cord-023095-4dannjjm 2648 2 - - HYPH cord-023095-4dannjjm 2648 3 related relate VBN cord-023095-4dannjjm 2648 4 effects effect NNS cord-023095-4dannjjm 2648 5 can can MD cord-023095-4dannjjm 2648 6 not not RB cord-023095-4dannjjm 2648 7 be be VB cord-023095-4dannjjm 2648 8 ruled rule VBN cord-023095-4dannjjm 2648 9 out out RP cord-023095-4dannjjm 2648 10 , , , cord-023095-4dannjjm 2648 11 and and CC cord-023095-4dannjjm 2648 12 further further JJ cord-023095-4dannjjm 2648 13 studies study NNS cord-023095-4dannjjm 2648 14 are be VBP cord-023095-4dannjjm 2648 15 warranted warrant VBN cord-023095-4dannjjm 2648 16 to to TO cord-023095-4dannjjm 2648 17 determine determine VB cord-023095-4dannjjm 2648 18 the the DT cord-023095-4dannjjm 2648 19 efficacy efficacy NN cord-023095-4dannjjm 2648 20 of of IN cord-023095-4dannjjm 2648 21 larazotide larazotide NN cord-023095-4dannjjm 2648 22 acetate acetate NN cord-023095-4dannjjm 2648 23 in in IN cord-023095-4dannjjm 2648 24 dogs dog NNS cord-023095-4dannjjm 2648 25 of of IN cord-023095-4dannjjm 2648 26 other other JJ cord-023095-4dannjjm 2648 27 breeds breed NNS cord-023095-4dannjjm 2648 28 with with IN cord-023095-4dannjjm 2648 29 GI GI NNP cord-023095-4dannjjm 2648 30 disease disease NN cord-023095-4dannjjm 2648 31 . . . cord-023095-4dannjjm 2649 1 to to TO cord-023095-4dannjjm 2649 2 analyze analyze VB cord-023095-4dannjjm 2649 3 different different JJ cord-023095-4dannjjm 2649 4 biochemical biochemical JJ cord-023095-4dannjjm 2649 5 markers marker NNS cord-023095-4dannjjm 2649 6 , , , cord-023095-4dannjjm 2649 7 calculate calculate VB cord-023095-4dannjjm 2649 8 clinical clinical JJ cord-023095-4dannjjm 2649 9 activity activity NN cord-023095-4dannjjm 2649 10 scores score NNS cord-023095-4dannjjm 2649 11 , , , cord-023095-4dannjjm 2649 12 and and CC cord-023095-4dannjjm 2649 13 assess assess VB cord-023095-4dannjjm 2649 14 survival survival NN cord-023095-4dannjjm 2649 15 in in IN cord-023095-4dannjjm 2649 16 dogs dog NNS cord-023095-4dannjjm 2649 17 with with IN cord-023095-4dannjjm 2649 18 PLE PLE NNP cord-023095-4dannjjm 2649 19 and and CC cord-023095-4dannjjm 2649 20 compare compare VB cord-023095-4dannjjm 2649 21 them -PRON- PRP cord-023095-4dannjjm 2649 22 with with IN cord-023095-4dannjjm 2649 23 those those DT cord-023095-4dannjjm 2649 24 in in IN cord-023095-4dannjjm 2649 25 dogs dog NNS cord-023095-4dannjjm 2649 26 with with IN cord-023095-4dannjjm 2649 27 food food NN cord-023095-4dannjjm 2649 28 - - HYPH cord-023095-4dannjjm 2649 29 responsive responsive JJ cord-023095-4dannjjm 2649 30 diarrhea diarrhea NN cord-023095-4dannjjm 2649 31 ( ( -LRB- cord-023095-4dannjjm 2649 32 FRD FRD NNP cord-023095-4dannjjm 2649 33 ) ) -RRB- cord-023095-4dannjjm 2649 34 without without IN cord-023095-4dannjjm 2649 35 protein protein NN cord-023095-4dannjjm 2649 36 loss loss NN cord-023095-4dannjjm 2649 37 . . . cord-023095-4dannjjm 2650 1 29 29 CD cord-023095-4dannjjm 2650 2 dogs dog NNS cord-023095-4dannjjm 2650 3 with with IN cord-023095-4dannjjm 2650 4 PLE PLE NNP cord-023095-4dannjjm 2650 5 and and CC cord-023095-4dannjjm 2650 6 18 18 CD cord-023095-4dannjjm 2650 7 dogs dog NNS cord-023095-4dannjjm 2650 8 with with IN cord-023095-4dannjjm 2650 9 FRD FRD NNP cord-023095-4dannjjm 2650 10 , , , cord-023095-4dannjjm 2650 11 referred refer VBD cord-023095-4dannjjm 2650 12 to to IN cord-023095-4dannjjm 2650 13 the the DT cord-023095-4dannjjm 2650 14 University University NNP cord-023095-4dannjjm 2650 15 of of IN cord-023095-4dannjjm 2650 16 Bern Bern NNP cord-023095-4dannjjm 2650 17 , , , cord-023095-4dannjjm 2650 18 CH CH NNP cord-023095-4dannjjm 2650 19 , , , cord-023095-4dannjjm 2650 20 were be VBD cord-023095-4dannjjm 2650 21 enrolled enrol VBN cord-023095-4dannjjm 2650 22 . . . cord-023095-4dannjjm 2651 1 Selection selection NN cord-023095-4dannjjm 2651 2 criteria criterion NNS cord-023095-4dannjjm 2651 3 included include VBD cord-023095-4dannjjm 2651 4 a a DT cord-023095-4dannjjm 2651 5 history history NN cord-023095-4dannjjm 2651 6 of of IN cord-023095-4dannjjm 2651 7 chronic chronic JJ cord-023095-4dannjjm 2651 8 diarrhea diarrhea NN cord-023095-4dannjjm 2651 9 ( ( -LRB- cord-023095-4dannjjm 2651 10 4 4 CD cord-023095-4dannjjm 2651 11 3 3 CD cord-023095-4dannjjm 2651 12 weeks week NNS cord-023095-4dannjjm 2651 13 ) ) -RRB- cord-023095-4dannjjm 2651 14 , , , cord-023095-4dannjjm 2651 15 exclusion exclusion NN cord-023095-4dannjjm 2651 16 of of IN cord-023095-4dannjjm 2651 17 identifiable identifiable JJ cord-023095-4dannjjm 2651 18 underlying underlying JJ cord-023095-4dannjjm 2651 19 causes cause NNS cord-023095-4dannjjm 2651 20 , , , cord-023095-4dannjjm 2651 21 and and CC cord-023095-4dannjjm 2651 22 histopathologic histopathologic JJ cord-023095-4dannjjm 2651 23 evidence evidence NN cord-023095-4dannjjm 2651 24 of of IN cord-023095-4dannjjm 2651 25 intestinal intestinal JJ cord-023095-4dannjjm 2651 26 inflammation inflammation NN cord-023095-4dannjjm 2651 27 , , , cord-023095-4dannjjm 2651 28 but but CC cord-023095-4dannjjm 2651 29 not not RB cord-023095-4dannjjm 2651 30 neoplasia neoplasia NN cord-023095-4dannjjm 2651 31 . . . cord-023095-4dannjjm 2652 1 Underlying underlying JJ cord-023095-4dannjjm 2652 2 disorders disorder NNS cord-023095-4dannjjm 2652 3 were be VBD cord-023095-4dannjjm 2652 4 excluded exclude VBN cord-023095-4dannjjm 2652 5 based base VBN cord-023095-4dannjjm 2652 6 on on IN cord-023095-4dannjjm 2652 7 CBC CBC NNP cord-023095-4dannjjm 2652 8 , , , cord-023095-4dannjjm 2652 9 chemistry chemistry NN cord-023095-4dannjjm 2652 10 profile profile NN cord-023095-4dannjjm 2652 11 , , , cord-023095-4dannjjm 2652 12 urinalysis urinalysis NN cord-023095-4dannjjm 2652 13 , , , cord-023095-4dannjjm 2652 14 fecal fecal JJ cord-023095-4dannjjm 2652 15 analysis analysis NN cord-023095-4dannjjm 2652 16 , , , cord-023095-4dannjjm 2652 17 trypsinlike trypsinlike NNP cord-023095-4dannjjm 2652 18 immunoreactivity immunoreactivity NN cord-023095-4dannjjm 2652 19 , , , cord-023095-4dannjjm 2652 20 cobalamin cobalamin NN cord-023095-4dannjjm 2652 21 , , , cord-023095-4dannjjm 2652 22 folate folate NN cord-023095-4dannjjm 2652 23 , , , cord-023095-4dannjjm 2652 24 and and CC cord-023095-4dannjjm 2652 25 transabdominal transabdominal JJ cord-023095-4dannjjm 2652 26 ultrasound ultrasound NN cord-023095-4dannjjm 2652 27 . . . cord-023095-4dannjjm 2653 1 Also also RB cord-023095-4dannjjm 2653 2 , , , cord-023095-4dannjjm 2653 3 canine canine JJ cord-023095-4dannjjm 2653 4 pancreatic pancreatic JJ cord-023095-4dannjjm 2653 5 lipase lipase NN cord-023095-4dannjjm 2653 6 immunoreactivity immunoreactivity NN cord-023095-4dannjjm 2653 7 ( ( -LRB- cord-023095-4dannjjm 2653 8 spec spec NN cord-023095-4dannjjm 2653 9 cPL cPL NNPS cord-023095-4dannjjm 2653 10 s s NNP cord-023095-4dannjjm 2653 11 ) ) -RRB- cord-023095-4dannjjm 2653 12 , , , cord-023095-4dannjjm 2653 13 C C NNP cord-023095-4dannjjm 2653 14 - - HYPH cord-023095-4dannjjm 2653 15 reactive reactive JJ cord-023095-4dannjjm 2653 16 protein protein NN cord-023095-4dannjjm 2653 17 ( ( -LRB- cord-023095-4dannjjm 2653 18 CRP CRP NNP cord-023095-4dannjjm 2653 19 ) ) -RRB- cord-023095-4dannjjm 2653 20 , , , cord-023095-4dannjjm 2653 21 calprotectin calprotectin NNP cord-023095-4dannjjm 2653 22 and and CC cord-023095-4dannjjm 2653 23 alpha alpha NN cord-023095-4dannjjm 2653 24 1 1 CD cord-023095-4dannjjm 2653 25 -proteinase -proteinase NN cord-023095-4dannjjm 2653 26 inhibitor inhibitor NN cord-023095-4dannjjm 2653 27 ( ( -LRB- cord-023095-4dannjjm 2653 28 a a DT cord-023095-4dannjjm 2653 29 1 1 CD cord-023095-4dannjjm 2653 30 -PI -pi NN cord-023095-4dannjjm 2653 31 ) ) -RRB- cord-023095-4dannjjm 2653 32 were be VBD cord-023095-4dannjjm 2653 33 measured measure VBN cord-023095-4dannjjm 2653 34 in in IN cord-023095-4dannjjm 2653 35 serum serum NN cord-023095-4dannjjm 2653 36 from from IN cord-023095-4dannjjm 2653 37 18 18 CD cord-023095-4dannjjm 2653 38 dogs dog NNS cord-023095-4dannjjm 2653 39 and and CC cord-023095-4dannjjm 2653 40 compared compare VBN cord-023095-4dannjjm 2653 41 with with IN cord-023095-4dannjjm 2653 42 18 18 CD cord-023095-4dannjjm 2653 43 dogs dog NNS cord-023095-4dannjjm 2653 44 with with IN cord-023095-4dannjjm 2653 45 FRD FRD NNP cord-023095-4dannjjm 2653 46 without without IN cord-023095-4dannjjm 2653 47 PLE PLE NNP cord-023095-4dannjjm 2653 48 . . . cord-023095-4dannjjm 2654 1 All all DT cord-023095-4dannjjm 2654 2 dogs dog NNS cord-023095-4dannjjm 2654 3 were be VBD cord-023095-4dannjjm 2654 4 scored score VBN cord-023095-4dannjjm 2654 5 using use VBG cord-023095-4dannjjm 2654 6 the the DT cord-023095-4dannjjm 2654 7 canine canine JJ cord-023095-4dannjjm 2654 8 IBD IBD NNP cord-023095-4dannjjm 2654 9 ( ( -LRB- cord-023095-4dannjjm 2654 10 CIBDAI CIBDAI NNP cord-023095-4dannjjm 2654 11 ) ) -RRB- cord-023095-4dannjjm 2654 12 and and CC cord-023095-4dannjjm 2654 13 the the DT cord-023095-4dannjjm 2654 14 canine canine JJ cord-023095-4dannjjm 2654 15 chronic chronic NN cord-023095-4dannjjm 2654 16 enteropathy enteropathy NNP cord-023095-4dannjjm 2654 17 ( ( -LRB- cord-023095-4dannjjm 2654 18 CCE CCE NNP cord-023095-4dannjjm 2654 19 ) ) -RRB- cord-023095-4dannjjm 2654 20 clinical clinical JJ cord-023095-4dannjjm 2654 21 activity activity NN cord-023095-4dannjjm 2654 22 index index NN cord-023095-4dannjjm 2654 23 ( ( -LRB- cord-023095-4dannjjm 2654 24 CCECAI CCECAI NNP cord-023095-4dannjjm 2654 25 ) ) -RRB- cord-023095-4dannjjm 2654 26 . . . cord-023095-4dannjjm 2655 1 Total total JJ cord-023095-4dannjjm 2655 2 protein protein NN cord-023095-4dannjjm 2655 3 , , , cord-023095-4dannjjm 2655 4 albumin albumin NN cord-023095-4dannjjm 2655 5 ( ( -LRB- cord-023095-4dannjjm 2655 6 5 5 CD cord-023095-4dannjjm 2655 7 - - SYM cord-023095-4dannjjm 2655 8 28.1 28.1 CD cord-023095-4dannjjm 2655 9 g g NN cord-023095-4dannjjm 2655 10 / / SYM cord-023095-4dannjjm 2655 11 l l NNP cord-023095-4dannjjm 2655 12 ) ) -RRB- cord-023095-4dannjjm 2655 13 , , , cord-023095-4dannjjm 2655 14 and and CC cord-023095-4dannjjm 2655 15 total total JJ cord-023095-4dannjjm 2655 16 calcium calcium NN cord-023095-4dannjjm 2655 17 ( ( -LRB- cord-023095-4dannjjm 2655 18 1.21 1.21 CD cord-023095-4dannjjm 2655 19 - - HYPH cord-023095-4dannjjm 2655 20 2.32 2.32 CD cord-023095-4dannjjm 2655 21 mmol mmol NNP cord-023095-4dannjjm 2655 22 / / SYM cord-023095-4dannjjm 2655 23 l l NN cord-023095-4dannjjm 2655 24 ) ) -RRB- cord-023095-4dannjjm 2655 25 were be VBD cord-023095-4dannjjm 2655 26 decreased decrease VBN cord-023095-4dannjjm 2655 27 in in IN cord-023095-4dannjjm 2655 28 all all DT cord-023095-4dannjjm 2655 29 29 29 CD cord-023095-4dannjjm 2655 30 dogs dog NNS cord-023095-4dannjjm 2655 31 . . . cord-023095-4dannjjm 2656 1 Cobalamin Cobalamin NNP cord-023095-4dannjjm 2656 2 was be VBD cord-023095-4dannjjm 2656 3 decreased decrease VBN cord-023095-4dannjjm 2656 4 in in IN cord-023095-4dannjjm 2656 5 all all DT cord-023095-4dannjjm 2656 6 but but CC cord-023095-4dannjjm 2656 7 3 3 CD cord-023095-4dannjjm 2656 8 dogs dog NNS cord-023095-4dannjjm 2656 9 ( ( -LRB- cord-023095-4dannjjm 2656 10 o o UH cord-023095-4dannjjm 2656 11 100 100 CD cord-023095-4dannjjm 2656 12 - - SYM cord-023095-4dannjjm 2656 13 490 490 CD cord-023095-4dannjjm 2656 14 ng ng NN cord-023095-4dannjjm 2656 15 / / SYM cord-023095-4dannjjm 2656 16 l l NN cord-023095-4dannjjm 2656 17 ) ) -RRB- cord-023095-4dannjjm 2656 18 . . . cord-023095-4dannjjm 2657 1 Spec spec NN cord-023095-4dannjjm 2657 2 cPL cPL NNS cord-023095-4dannjjm 2657 3 was be VBD cord-023095-4dannjjm 2657 4 mildly mildly RB cord-023095-4dannjjm 2657 5 increased increase VBN cord-023095-4dannjjm 2657 6 in in IN cord-023095-4dannjjm 2657 7 3/18 3/18 CD cord-023095-4dannjjm 2657 8 dogs dog NNS cord-023095-4dannjjm 2657 9 with with IN cord-023095-4dannjjm 2657 10 PLE PLE NNP cord-023095-4dannjjm 2657 11 and and CC cord-023095-4dannjjm 2657 12 normal normal JJ cord-023095-4dannjjm 2657 13 in in IN cord-023095-4dannjjm 2657 14 15/18 15/18 CD cord-023095-4dannjjm 2657 15 PLE PLE NNP cord-023095-4dannjjm 2657 16 and and CC cord-023095-4dannjjm 2657 17 all all DT cord-023095-4dannjjm 2657 18 FRD FRD NNP cord-023095-4dannjjm 2657 19 dogs dog NNS cord-023095-4dannjjm 2657 20 . . . cord-023095-4dannjjm 2658 1 CRP CRP NNP cord-023095-4dannjjm 2658 2 was be VBD cord-023095-4dannjjm 2658 3 normal normal JJ cord-023095-4dannjjm 2658 4 in in IN cord-023095-4dannjjm 2658 5 5/18 5/18 CD cord-023095-4dannjjm 2658 6 dogs dog NNS cord-023095-4dannjjm 2658 7 with with IN cord-023095-4dannjjm 2658 8 PLE PLE NNP cord-023095-4dannjjm 2658 9 ( ( -LRB- cord-023095-4dannjjm 2658 10 16/18 16/18 CD cord-023095-4dannjjm 2658 11 FRD FRD NNP cord-023095-4dannjjm 2658 12 ) ) -RRB- cord-023095-4dannjjm 2658 13 , , , cord-023095-4dannjjm 2658 14 mildly mildly RB cord-023095-4dannjjm 2658 15 increased increase VBD cord-023095-4dannjjm 2658 16 in in IN cord-023095-4dannjjm 2658 17 7/18 7/18 CD cord-023095-4dannjjm 2658 18 ( ( -LRB- cord-023095-4dannjjm 2658 19 1/18 1/18 CD cord-023095-4dannjjm 2658 20 FRD FRD NNP cord-023095-4dannjjm 2658 21 ) ) -RRB- cord-023095-4dannjjm 2658 22 , , , cord-023095-4dannjjm 2658 23 and and CC cord-023095-4dannjjm 2658 24 moderately moderately RB cord-023095-4dannjjm 2658 25 increased increase VBD cord-023095-4dannjjm 2658 26 in in IN cord-023095-4dannjjm 2658 27 6/18 6/18 CD cord-023095-4dannjjm 2658 28 PLE PLE NNP cord-023095-4dannjjm 2658 29 dogs dog NNS cord-023095-4dannjjm 2658 30 ( ( -LRB- cord-023095-4dannjjm 2658 31 1/18 1/18 CD cord-023095-4dannjjm 2658 32 FRD FRD NNP cord-023095-4dannjjm 2658 33 ) ) -RRB- cord-023095-4dannjjm 2658 34 . . . cord-023095-4dannjjm 2659 1 Calprotectin Calprotectin NNP cord-023095-4dannjjm 2659 2 was be VBD cord-023095-4dannjjm 2659 3 slightly slightly RB cord-023095-4dannjjm 2659 4 higher high JJR cord-023095-4dannjjm 2659 5 in in IN cord-023095-4dannjjm 2659 6 dogs dog NNS cord-023095-4dannjjm 2659 7 with with IN cord-023095-4dannjjm 2659 8 PLE PLE NNP cord-023095-4dannjjm 2659 9 , , , cord-023095-4dannjjm 2659 10 but but CC cord-023095-4dannjjm 2659 11 all all DT cord-023095-4dannjjm 2659 12 PLE PLE NNP cord-023095-4dannjjm 2659 13 and and CC cord-023095-4dannjjm 2659 14 FRD FRD NNP cord-023095-4dannjjm 2659 15 dogs dog NNS cord-023095-4dannjjm 2659 16 yielded yield VBD cord-023095-4dannjjm 2659 17 values value NNS cord-023095-4dannjjm 2659 18 in in IN cord-023095-4dannjjm 2659 19 the the DT cord-023095-4dannjjm 2659 20 normal normal JJ cord-023095-4dannjjm 2659 21 range range NN cord-023095-4dannjjm 2659 22 . . . cord-023095-4dannjjm 2660 1 Serum serum NN cord-023095-4dannjjm 2661 1 a a DT cord-023095-4dannjjm 2661 2 1 1 CD cord-023095-4dannjjm 2661 3 -PI -pi NN cord-023095-4dannjjm 2661 4 was be VBD cord-023095-4dannjjm 2661 5 significantly significantly RB cord-023095-4dannjjm 2661 6 lower low JJR cord-023095-4dannjjm 2661 7 in in IN cord-023095-4dannjjm 2661 8 dogs dog NNS cord-023095-4dannjjm 2661 9 with with IN cord-023095-4dannjjm 2661 10 PLE PLE NNP cord-023095-4dannjjm 2661 11 than than IN cord-023095-4dannjjm 2661 12 in in IN cord-023095-4dannjjm 2661 13 those those DT cord-023095-4dannjjm 2661 14 with with IN cord-023095-4dannjjm 2661 15 FRD FRD NNP cord-023095-4dannjjm 2661 16 ( ( -LRB- cord-023095-4dannjjm 2661 17 p p NN cord-023095-4dannjjm 2661 18 o o CD cord-023095-4dannjjm 2661 19 0.001 0.001 CD cord-023095-4dannjjm 2661 20 ) ) -RRB- cord-023095-4dannjjm 2661 21 , , , cord-023095-4dannjjm 2661 22 with with IN cord-023095-4dannjjm 2661 23 13/18 13/18 CD cord-023095-4dannjjm 2661 24 PLE PLE NNP cord-023095-4dannjjm 2661 25 dogs dog NNS cord-023095-4dannjjm 2661 26 below below IN cord-023095-4dannjjm 2661 27 the the DT cord-023095-4dannjjm 2661 28 reference reference NN cord-023095-4dannjjm 2661 29 range range NN cord-023095-4dannjjm 2661 30 ( ( -LRB- cord-023095-4dannjjm 2661 31 1/18 1/18 CD cord-023095-4dannjjm 2661 32 FRD FRD NNP cord-023095-4dannjjm 2661 33 ) ) -RRB- cord-023095-4dannjjm 2661 34 . . . cord-023095-4dannjjm 2662 1 CIBDAI CIBDAI NNP cord-023095-4dannjjm 2662 2 ranged range VBD cord-023095-4dannjjm 2662 3 from from IN cord-023095-4dannjjm 2662 4 4 4 CD cord-023095-4dannjjm 2662 5 to to IN cord-023095-4dannjjm 2662 6 16 16 CD cord-023095-4dannjjm 2662 7 and and CC cord-023095-4dannjjm 2662 8 CCECAI CCECAI NNP cord-023095-4dannjjm 2662 9 from from IN cord-023095-4dannjjm 2662 10 6 6 CD cord-023095-4dannjjm 2662 11 to to IN cord-023095-4dannjjm 2662 12 19 19 CD cord-023095-4dannjjm 2662 13 . . . cord-023095-4dannjjm 2663 1 At at IN cord-023095-4dannjjm 2663 2 the the DT cord-023095-4dannjjm 2663 3 end end NN cord-023095-4dannjjm 2663 4 of of IN cord-023095-4dannjjm 2663 5 the the DT cord-023095-4dannjjm 2663 6 study study NN cord-023095-4dannjjm 2663 7 , , , cord-023095-4dannjjm 2663 8 12/29 12/29 CD cord-023095-4dannjjm 2663 9 dogs dog NNS cord-023095-4dannjjm 2663 10 were be VBD cord-023095-4dannjjm 2663 11 still still RB cord-023095-4dannjjm 2663 12 alive alive JJ cord-023095-4dannjjm 2663 13 with with IN cord-023095-4dannjjm 2663 14 survival survival NN cord-023095-4dannjjm 2663 15 times time NNS cord-023095-4dannjjm 2663 16 between between IN cord-023095-4dannjjm 2663 17 26 26 CD cord-023095-4dannjjm 2663 18 and and CC cord-023095-4dannjjm 2663 19 2544 2544 CD cord-023095-4dannjjm 2663 20 days day NNS cord-023095-4dannjjm 2663 21 . . . cord-023095-4dannjjm 2664 1 17/29 17/29 CD cord-023095-4dannjjm 2664 2 dogs dog NNS cord-023095-4dannjjm 2664 3 died die VBD cord-023095-4dannjjm 2664 4 with with IN cord-023095-4dannjjm 2664 5 a a DT cord-023095-4dannjjm 2664 6 median median JJ cord-023095-4dannjjm 2664 7 survival survival NN cord-023095-4dannjjm 2664 8 of of IN cord-023095-4dannjjm 2664 9 96 96 CD cord-023095-4dannjjm 2664 10 days day NNS cord-023095-4dannjjm 2664 11 ( ( -LRB- cord-023095-4dannjjm 2664 12 range range NNP cord-023095-4dannjjm 2664 13 2 2 CD cord-023095-4dannjjm 2664 14 - - SYM cord-023095-4dannjjm 2664 15 874 874 CD cord-023095-4dannjjm 2664 16 days day NNS cord-023095-4dannjjm 2664 17 ) ) -RRB- cord-023095-4dannjjm 2664 18 . . . cord-023095-4dannjjm 2665 1 Dogs dog NNS cord-023095-4dannjjm 2665 2 with with IN cord-023095-4dannjjm 2665 3 mildly mildly RB cord-023095-4dannjjm 2665 4 increased increase VBN cord-023095-4dannjjm 2665 5 CRP CRP NNP cord-023095-4dannjjm 2665 6 died die VBD cord-023095-4dannjjm 2665 7 earlier early RBR cord-023095-4dannjjm 2665 8 than than IN cord-023095-4dannjjm 2665 9 dogs dog NNS cord-023095-4dannjjm 2665 10 with with IN cord-023095-4dannjjm 2665 11 a a DT cord-023095-4dannjjm 2665 12 normal normal JJ cord-023095-4dannjjm 2665 13 or or CC cord-023095-4dannjjm 2665 14 moderately moderately RB cord-023095-4dannjjm 2665 15 increased increase VBN cord-023095-4dannjjm 2665 16 CRP CRP NNP cord-023095-4dannjjm 2665 17 ( ( -LRB- cord-023095-4dannjjm 2665 18 p p NN cord-023095-4dannjjm 2665 19 5 5 CD cord-023095-4dannjjm 2665 20 0.011 0.011 CD cord-023095-4dannjjm 2665 21 ) ) -RRB- cord-023095-4dannjjm 2665 22 , , , cord-023095-4dannjjm 2665 23 whereas whereas IN cord-023095-4dannjjm 2665 24 albumin albumin NN cord-023095-4dannjjm 2665 25 , , , cord-023095-4dannjjm 2665 26 calcium calcium NN cord-023095-4dannjjm 2665 27 , , , cord-023095-4dannjjm 2665 28 Spec Spec NNP cord-023095-4dannjjm 2665 29 cPL cPL NNS cord-023095-4dannjjm 2665 30 , , , cord-023095-4dannjjm 2665 31 calprotectin calprotectin NNP cord-023095-4dannjjm 2665 32 , , , cord-023095-4dannjjm 2665 33 CIBDAI CIBDAI NNP cord-023095-4dannjjm 2665 34 , , , cord-023095-4dannjjm 2665 35 and and CC cord-023095-4dannjjm 2665 36 CCECAI CCECAI NNP cord-023095-4dannjjm 2665 37 had have VBD cord-023095-4dannjjm 2665 38 no no DT cord-023095-4dannjjm 2665 39 significant significant JJ cord-023095-4dannjjm 2665 40 impact impact NN cord-023095-4dannjjm 2665 41 on on IN cord-023095-4dannjjm 2665 42 outcome outcome NN cord-023095-4dannjjm 2665 43 and and CC cord-023095-4dannjjm 2665 44 survival survival NN cord-023095-4dannjjm 2665 45 . . . cord-023095-4dannjjm 2666 1 In in IN cord-023095-4dannjjm 2666 2 conclusion conclusion NN cord-023095-4dannjjm 2666 3 , , , cord-023095-4dannjjm 2666 4 dogs dog NNS cord-023095-4dannjjm 2666 5 with with IN cord-023095-4dannjjm 2666 6 PLE PLE NNP cord-023095-4dannjjm 2666 7 have have VBP cord-023095-4dannjjm 2666 8 a a DT cord-023095-4dannjjm 2666 9 significantly significantly RB cord-023095-4dannjjm 2666 10 lower low JJR cord-023095-4dannjjm 2666 11 a1-PI a1-pi JJ cord-023095-4dannjjm 2666 12 in in IN cord-023095-4dannjjm 2666 13 the the DT cord-023095-4dannjjm 2666 14 serum serum NN cord-023095-4dannjjm 2666 15 than than IN cord-023095-4dannjjm 2666 16 dogs dog NNS cord-023095-4dannjjm 2666 17 with with IN cord-023095-4dannjjm 2666 18 FRD FRD NNP cord-023095-4dannjjm 2666 19 . . . cord-023095-4dannjjm 2667 1 Furthermore furthermore RB cord-023095-4dannjjm 2667 2 , , , cord-023095-4dannjjm 2667 3 most most JJS cord-023095-4dannjjm 2667 4 dogs dog NNS cord-023095-4dannjjm 2667 5 with with IN cord-023095-4dannjjm 2667 6 PLE PLE NNP cord-023095-4dannjjm 2667 7 have have VBP cord-023095-4dannjjm 2667 8 an an DT cord-023095-4dannjjm 2667 9 increased increase VBN cord-023095-4dannjjm 2667 10 CRP crp NN cord-023095-4dannjjm 2667 11 and and CC cord-023095-4dannjjm 2667 12 a a DT cord-023095-4dannjjm 2667 13 decreased decrease VBN cord-023095-4dannjjm 2667 14 cobalamin cobalamin NN cord-023095-4dannjjm 2667 15 . . . cord-023095-4dannjjm 2668 1 A a DT cord-023095-4dannjjm 2668 2 mild mild JJ cord-023095-4dannjjm 2668 3 increase increase NN cord-023095-4dannjjm 2668 4 in in IN cord-023095-4dannjjm 2668 5 CRP CRP NNP cord-023095-4dannjjm 2668 6 appears appear VBZ cord-023095-4dannjjm 2668 7 to to TO cord-023095-4dannjjm 2668 8 be be VB cord-023095-4dannjjm 2668 9 a a DT cord-023095-4dannjjm 2668 10 poor poor JJ cord-023095-4dannjjm 2668 11 prognostic prognostic JJ cord-023095-4dannjjm 2668 12 factor factor NN cord-023095-4dannjjm 2668 13 . . . cord-023095-4dannjjm 2669 1 While while IN cord-023095-4dannjjm 2669 2 hypoalbuminemia hypoalbuminemia NNP cord-023095-4dannjjm 2669 3 is be VBZ cord-023095-4dannjjm 2669 4 a a DT cord-023095-4dannjjm 2669 5 common common JJ cord-023095-4dannjjm 2669 6 finding finding NN cord-023095-4dannjjm 2669 7 associated associate VBN cord-023095-4dannjjm 2669 8 with with IN cord-023095-4dannjjm 2669 9 chronic chronic JJ cord-023095-4dannjjm 2669 10 enteropathies enteropathy NNS cord-023095-4dannjjm 2669 11 , , , cord-023095-4dannjjm 2669 12 its -PRON- PRP$ cord-023095-4dannjjm 2669 13 impact impact NN cord-023095-4dannjjm 2669 14 on on IN cord-023095-4dannjjm 2669 15 survival survival NN cord-023095-4dannjjm 2669 16 in in IN cord-023095-4dannjjm 2669 17 this this DT cord-023095-4dannjjm 2669 18 population population NN cord-023095-4dannjjm 2669 19 is be VBZ cord-023095-4dannjjm 2669 20 poorly poorly RB cord-023095-4dannjjm 2669 21 defined define VBN cord-023095-4dannjjm 2669 22 . . . cord-023095-4dannjjm 2670 1 The the DT cord-023095-4dannjjm 2670 2 aim aim NN cord-023095-4dannjjm 2670 3 of of IN cord-023095-4dannjjm 2670 4 this this DT cord-023095-4dannjjm 2670 5 study study NN cord-023095-4dannjjm 2670 6 was be VBD cord-023095-4dannjjm 2670 7 to to TO cord-023095-4dannjjm 2670 8 compare compare VB cord-023095-4dannjjm 2670 9 dogs dog NNS cord-023095-4dannjjm 2670 10 with with IN cord-023095-4dannjjm 2670 11 chronic chronic JJ cord-023095-4dannjjm 2670 12 enteropathies enteropathy NNS cord-023095-4dannjjm 2670 13 on on IN cord-023095-4dannjjm 2670 14 the the DT cord-023095-4dannjjm 2670 15 basis basis NN cord-023095-4dannjjm 2670 16 of of IN cord-023095-4dannjjm 2670 17 their -PRON- PRP$ cord-023095-4dannjjm 2670 18 serum serum NN cord-023095-4dannjjm 2670 19 albumin albumin NN cord-023095-4dannjjm 2670 20 concentration concentration NN cord-023095-4dannjjm 2670 21 at at IN cord-023095-4dannjjm 2670 22 the the DT cord-023095-4dannjjm 2670 23 time time NN cord-023095-4dannjjm 2670 24 of of IN cord-023095-4dannjjm 2670 25 presentation presentation NN cord-023095-4dannjjm 2670 26 . . . cord-023095-4dannjjm 2671 1 We -PRON- PRP cord-023095-4dannjjm 2671 2 hypothesized hypothesize VBD cord-023095-4dannjjm 2671 3 that that IN cord-023095-4dannjjm 2671 4 dogs dog NNS cord-023095-4dannjjm 2671 5 with with IN cord-023095-4dannjjm 2671 6 a a DT cord-023095-4dannjjm 2671 7 protein protein NN cord-023095-4dannjjm 2671 8 losing lose VBG cord-023095-4dannjjm 2671 9 enteropathy enteropathy NNS cord-023095-4dannjjm 2671 10 ( ( -LRB- cord-023095-4dannjjm 2671 11 PLE PLE NNP cord-023095-4dannjjm 2671 12 ) ) -RRB- cord-023095-4dannjjm 2671 13 have have VBP cord-023095-4dannjjm 2671 14 a a DT cord-023095-4dannjjm 2671 15 significantly significantly RB cord-023095-4dannjjm 2671 16 shorter short JJR cord-023095-4dannjjm 2671 17 survival survival NN cord-023095-4dannjjm 2671 18 time time NN cord-023095-4dannjjm 2671 19 compared compare VBN cord-023095-4dannjjm 2671 20 to to IN cord-023095-4dannjjm 2671 21 dogs dog NNS cord-023095-4dannjjm 2671 22 with with IN cord-023095-4dannjjm 2671 23 chronic chronic JJ cord-023095-4dannjjm 2671 24 enteropathies enteropathy NNS cord-023095-4dannjjm 2671 25 which which WDT cord-023095-4dannjjm 2671 26 are be VBP cord-023095-4dannjjm 2671 27 not not RB cord-023095-4dannjjm 2671 28 hypoalbuminemic hypoalbuminemic JJ cord-023095-4dannjjm 2671 29 ( ( -LRB- cord-023095-4dannjjm 2671 30 controls control NNS cord-023095-4dannjjm 2671 31 ) ) -RRB- cord-023095-4dannjjm 2671 32 . . . cord-023095-4dannjjm 2672 1 Information information NN cord-023095-4dannjjm 2672 2 obtained obtain VBN cord-023095-4dannjjm 2672 3 from from IN cord-023095-4dannjjm 2672 4 the the DT cord-023095-4dannjjm 2672 5 medical medical JJ cord-023095-4dannjjm 2672 6 records record NNS cord-023095-4dannjjm 2672 7 included include VBD cord-023095-4dannjjm 2672 8 signalment signalment JJ cord-023095-4dannjjm 2672 9 , , , cord-023095-4dannjjm 2672 10 duration duration NN cord-023095-4dannjjm 2672 11 and and CC cord-023095-4dannjjm 2672 12 characteristics characteristic NNS cord-023095-4dannjjm 2672 13 of of IN cord-023095-4dannjjm 2672 14 clinical clinical JJ cord-023095-4dannjjm 2672 15 signs sign NNS cord-023095-4dannjjm 2672 16 , , , cord-023095-4dannjjm 2672 17 physical physical JJ cord-023095-4dannjjm 2672 18 examination examination NN cord-023095-4dannjjm 2672 19 findings finding NNS cord-023095-4dannjjm 2672 20 , , , cord-023095-4dannjjm 2672 21 clinicopathologic clinicopathologic NNP cord-023095-4dannjjm 2672 22 data datum NNS cord-023095-4dannjjm 2672 23 and and CC cord-023095-4dannjjm 2672 24 survival survival NN cord-023095-4dannjjm 2672 25 time time NN cord-023095-4dannjjm 2672 26 . . . cord-023095-4dannjjm 2673 1 One one CD cord-023095-4dannjjm 2673 2 hundred hundred CD cord-023095-4dannjjm 2673 3 seventeen seventeen CD cord-023095-4dannjjm 2673 4 cases case NNS cord-023095-4dannjjm 2673 5 fit fit VBP cord-023095-4dannjjm 2673 6 the the DT cord-023095-4dannjjm 2673 7 inclusion inclusion NN cord-023095-4dannjjm 2673 8 criteria criterion NNS cord-023095-4dannjjm 2673 9 ; ; : cord-023095-4dannjjm 2673 10 68 68 CD cord-023095-4dannjjm 2673 11 in in IN cord-023095-4dannjjm 2673 12 the the DT cord-023095-4dannjjm 2673 13 PLE PLE NNP cord-023095-4dannjjm 2673 14 group group NN cord-023095-4dannjjm 2673 15 and and CC cord-023095-4dannjjm 2673 16 49 49 CD cord-023095-4dannjjm 2673 17 controls control NNS cord-023095-4dannjjm 2673 18 . . . cord-023095-4dannjjm 2674 1 There there EX cord-023095-4dannjjm 2674 2 was be VBD cord-023095-4dannjjm 2674 3 no no DT cord-023095-4dannjjm 2674 4 statistical statistical JJ cord-023095-4dannjjm 2674 5 significance significance NN cord-023095-4dannjjm 2674 6 between between IN cord-023095-4dannjjm 2674 7 groups group NNS cord-023095-4dannjjm 2674 8 for for IN cord-023095-4dannjjm 2674 9 age age NN cord-023095-4dannjjm 2674 10 ( ( -LRB- cord-023095-4dannjjm 2674 11 P p NN cord-023095-4dannjjm 2674 12 5 5 CD cord-023095-4dannjjm 2674 13 0.12 0.12 CD cord-023095-4dannjjm 2674 14 ) ) -RRB- cord-023095-4dannjjm 2674 15 , , , cord-023095-4dannjjm 2674 16 weight weight NN cord-023095-4dannjjm 2674 17 ( ( -LRB- cord-023095-4dannjjm 2674 18 P p NN cord-023095-4dannjjm 2674 19 5 5 CD cord-023095-4dannjjm 2674 20 0.17 0.17 CD cord-023095-4dannjjm 2674 21 ) ) -RRB- cord-023095-4dannjjm 2674 22 , , , cord-023095-4dannjjm 2674 23 weight weight NN cord-023095-4dannjjm 2674 24 loss loss NN cord-023095-4dannjjm 2674 25 ( ( -LRB- cord-023095-4dannjjm 2674 26 P p NN cord-023095-4dannjjm 2674 27 5 5 CD cord-023095-4dannjjm 2674 28 0.59 0.59 CD cord-023095-4dannjjm 2674 29 ) ) -RRB- cord-023095-4dannjjm 2674 30 and and CC cord-023095-4dannjjm 2674 31 body body NN cord-023095-4dannjjm 2674 32 condition condition NN cord-023095-4dannjjm 2674 33 score score NN cord-023095-4dannjjm 2674 34 ( ( -LRB- cord-023095-4dannjjm 2674 35 P p NN cord-023095-4dannjjm 2674 36 5 5 CD cord-023095-4dannjjm 2674 37 0.072 0.072 CD cord-023095-4dannjjm 2674 38 ) ) -RRB- cord-023095-4dannjjm 2674 39 . . . cord-023095-4dannjjm 2675 1 Compared compare VBN cord-023095-4dannjjm 2675 2 to to TO cord-023095-4dannjjm 2675 3 control control VB cord-023095-4dannjjm 2675 4 dogs dog NNS cord-023095-4dannjjm 2675 5 , , , cord-023095-4dannjjm 2675 6 PLE PLE NNP cord-023095-4dannjjm 2675 7 dogs dog NNS cord-023095-4dannjjm 2675 8 had have VBD cord-023095-4dannjjm 2675 9 decreased decrease VBN cord-023095-4dannjjm 2675 10 serum serum NN cord-023095-4dannjjm 2675 11 concentrations concentration NNS cord-023095-4dannjjm 2675 12 of of IN cord-023095-4dannjjm 2675 13 cobalamin cobalamin NN cord-023095-4dannjjm 2675 14 ( ( -LRB- cord-023095-4dannjjm 2675 15 P p NN cord-023095-4dannjjm 2675 16 5 5 CD cord-023095-4dannjjm 2675 17 0.002 0.002 CD cord-023095-4dannjjm 2675 18 ) ) -RRB- cord-023095-4dannjjm 2675 19 , , , cord-023095-4dannjjm 2675 20 total total JJ cord-023095-4dannjjm 2675 21 calcium calcium NN cord-023095-4dannjjm 2675 22 ( ( -LRB- cord-023095-4dannjjm 2675 23 P p NN cord-023095-4dannjjm 2675 24 o o NN cord-023095-4dannjjm 2675 25 0.0001 0.0001 CD cord-023095-4dannjjm 2675 26 ) ) -RRB- cord-023095-4dannjjm 2675 27 , , , cord-023095-4dannjjm 2675 28 globulin globulin NN cord-023095-4dannjjm 2675 29 ( ( -LRB- cord-023095-4dannjjm 2675 30 P p NN cord-023095-4dannjjm 2675 31 o o NN cord-023095-4dannjjm 2675 32 0.0001 0.0001 CD cord-023095-4dannjjm 2675 33 ) ) -RRB- cord-023095-4dannjjm 2675 34 , , , cord-023095-4dannjjm 2675 35 cholesterol cholesterol NN cord-023095-4dannjjm 2675 36 ( ( -LRB- cord-023095-4dannjjm 2676 1 P p NN cord-023095-4dannjjm 2676 2 o o CD cord-023095-4dannjjm 2676 3 0.0001 0.0001 CD cord-023095-4dannjjm 2676 4 ) ) -RRB- cord-023095-4dannjjm 2676 5 and and CC cord-023095-4dannjjm 2676 6 ionized ionized JJ cord-023095-4dannjjm 2676 7 calcium calcium NN cord-023095-4dannjjm 2677 1 ( ( -LRB- cord-023095-4dannjjm 2677 2 P p NN cord-023095-4dannjjm 2677 3 o o NN cord-023095-4dannjjm 2677 4 0.001 0.001 CD cord-023095-4dannjjm 2677 5 ) ) -RRB- cord-023095-4dannjjm 2677 6 . . . cord-023095-4dannjjm 2678 1 Survival survival NN cord-023095-4dannjjm 2678 2 analysis analysis NN cord-023095-4dannjjm 2678 3 revealed reveal VBD cord-023095-4dannjjm 2678 4 a a DT cord-023095-4dannjjm 2678 5 significantly significantly RB cord-023095-4dannjjm 2678 6 decreased decrease VBN cord-023095-4dannjjm 2678 7 survival survival NN cord-023095-4dannjjm 2678 8 time time NN cord-023095-4dannjjm 2678 9 for for IN cord-023095-4dannjjm 2678 10 PLE PLE NNP cord-023095-4dannjjm 2678 11 dogs dog NNS cord-023095-4dannjjm 2678 12 ( ( -LRB- cord-023095-4dannjjm 2678 13 P p NN cord-023095-4dannjjm 2678 14 5 5 CD cord-023095-4dannjjm 2678 15 0.0008 0.0008 CD cord-023095-4dannjjm 2678 16 ) ) -RRB- cord-023095-4dannjjm 2678 17 ; ; : cord-023095-4dannjjm 2678 18 median median JJ cord-023095-4dannjjm 2678 19 survival survival NN cord-023095-4dannjjm 2678 20 was be VBD cord-023095-4dannjjm 2678 21 701 701 CD cord-023095-4dannjjm 2678 22 days day NNS cord-023095-4dannjjm 2678 23 for for IN cord-023095-4dannjjm 2678 24 PLE PLE NNP cord-023095-4dannjjm 2678 25 dogs dog NNS cord-023095-4dannjjm 2678 26 and and CC cord-023095-4dannjjm 2678 27 4 4 CD cord-023095-4dannjjm 2678 28 3,500 3,500 CD cord-023095-4dannjjm 2678 29 days day NNS cord-023095-4dannjjm 2678 30 for for IN cord-023095-4dannjjm 2678 31 controls control NNS cord-023095-4dannjjm 2678 32 . . . cord-023095-4dannjjm 2679 1 While while IN cord-023095-4dannjjm 2679 2 the the DT cord-023095-4dannjjm 2679 3 PLE PLE NNP cord-023095-4dannjjm 2679 4 group group NN cord-023095-4dannjjm 2679 5 did do VBD cord-023095-4dannjjm 2679 6 not not RB cord-023095-4dannjjm 2679 7 survive survive VB cord-023095-4dannjjm 2679 8 as as RB cord-023095-4dannjjm 2679 9 long long JJ cord-023095-4dannjjm 2679 10 , , , cord-023095-4dannjjm 2679 11 survival survival NN cord-023095-4dannjjm 2679 12 was be VBD cord-023095-4dannjjm 2679 13 not not RB cord-023095-4dannjjm 2679 14 directly directly RB cord-023095-4dannjjm 2679 15 associated associate VBN cord-023095-4dannjjm 2679 16 with with IN cord-023095-4dannjjm 2679 17 severity severity NN cord-023095-4dannjjm 2679 18 of of IN cord-023095-4dannjjm 2679 19 hypoalbuminemia hypoalbuminemia NN cord-023095-4dannjjm 2679 20 ; ; : cord-023095-4dannjjm 2679 21 patients patient NNS cord-023095-4dannjjm 2679 22 with with IN cord-023095-4dannjjm 2679 23 albumin albumin NN cord-023095-4dannjjm 2679 24 concentration concentration NN cord-023095-4dannjjm 2679 25 o o NN cord-023095-4dannjjm 2679 26 1.3 1.3 CD cord-023095-4dannjjm 2679 27 g g NN cord-023095-4dannjjm 2679 28 / / SYM cord-023095-4dannjjm 2679 29 dL dl NN cord-023095-4dannjjm 2679 30 survived survive VBD cord-023095-4dannjjm 2679 31 longer long RBR cord-023095-4dannjjm 2679 32 than than IN cord-023095-4dannjjm 2679 33 those those DT cord-023095-4dannjjm 2679 34 with with IN cord-023095-4dannjjm 2679 35 mild mild JJ cord-023095-4dannjjm 2679 36 hypoalbuminemia hypoalbuminemia NN cord-023095-4dannjjm 2679 37 ( ( -LRB- cord-023095-4dannjjm 2679 38 1.6 1.6 CD cord-023095-4dannjjm 2679 39 - - SYM cord-023095-4dannjjm 2679 40 1.9 1.9 CD cord-023095-4dannjjm 2679 41 g g NN cord-023095-4dannjjm 2679 42 / / SYM cord-023095-4dannjjm 2679 43 dL dl NN cord-023095-4dannjjm 2679 44 ) ) -RRB- cord-023095-4dannjjm 2679 45 . . . cord-023095-4dannjjm 2680 1 This this DT cord-023095-4dannjjm 2680 2 study study NN cord-023095-4dannjjm 2680 3 supports support VBZ cord-023095-4dannjjm 2680 4 the the DT cord-023095-4dannjjm 2680 5 observation observation NN cord-023095-4dannjjm 2680 6 that that IN cord-023095-4dannjjm 2680 7 chronic chronic JJ cord-023095-4dannjjm 2680 8 enteropathy enteropathy NN cord-023095-4dannjjm 2680 9 patients patient NNS cord-023095-4dannjjm 2680 10 have have VBP cord-023095-4dannjjm 2680 11 decreased decrease VBN cord-023095-4dannjjm 2680 12 survival survival NN cord-023095-4dannjjm 2680 13 time time NN cord-023095-4dannjjm 2680 14 when when WRB cord-023095-4dannjjm 2680 15 presented present VBN cord-023095-4dannjjm 2680 16 with with IN cord-023095-4dannjjm 2680 17 hypoalbuminemia hypoalbuminemia NN cord-023095-4dannjjm 2680 18 ; ; : cord-023095-4dannjjm 2680 19 however however RB cord-023095-4dannjjm 2680 20 this this DT cord-023095-4dannjjm 2680 21 study study NN cord-023095-4dannjjm 2680 22 suggests suggest VBZ cord-023095-4dannjjm 2680 23 the the DT cord-023095-4dannjjm 2680 24 severity severity NN cord-023095-4dannjjm 2680 25 of of IN cord-023095-4dannjjm 2680 26 hypoalbuminemia hypoalbuminemia NN cord-023095-4dannjjm 2680 27 is be VBZ cord-023095-4dannjjm 2680 28 not not RB cord-023095-4dannjjm 2680 29 a a DT cord-023095-4dannjjm 2680 30 reliable reliable JJ cord-023095-4dannjjm 2680 31 indicator indicator NN cord-023095-4dannjjm 2680 32 of of IN cord-023095-4dannjjm 2680 33 survival survival NN cord-023095-4dannjjm 2680 34 . . . cord-023095-4dannjjm 2681 1 Cobalamin Cobalamin NNP cord-023095-4dannjjm 2681 2 ( ( -LRB- cord-023095-4dannjjm 2681 3 vitamin vitamin NN cord-023095-4dannjjm 2681 4 B b NN cord-023095-4dannjjm 2681 5 12 12 CD cord-023095-4dannjjm 2681 6 ) ) -RRB- cord-023095-4dannjjm 2681 7 deficiency deficiency NN cord-023095-4dannjjm 2681 8 in in IN cord-023095-4dannjjm 2681 9 the the DT cord-023095-4dannjjm 2681 10 Chinese chinese JJ cord-023095-4dannjjm 2681 11 Shar Shar NNP cord-023095-4dannjjm 2681 12 Pei Pei NNP cord-023095-4dannjjm 2681 13 ( ( -LRB- cord-023095-4dannjjm 2681 14 Shar Shar NNP cord-023095-4dannjjm 2681 15 Pei Pei NNP cord-023095-4dannjjm 2681 16 ) ) -RRB- cord-023095-4dannjjm 2681 17 is be VBZ cord-023095-4dannjjm 2681 18 suspected suspect VBN cord-023095-4dannjjm 2681 19 to to TO cord-023095-4dannjjm 2681 20 be be VB cord-023095-4dannjjm 2681 21 hereditary hereditary JJ cord-023095-4dannjjm 2681 22 . . . cord-023095-4dannjjm 2682 1 Inherited inherit VBN cord-023095-4dannjjm 2682 2 causes cause NNS cord-023095-4dannjjm 2682 3 of of IN cord-023095-4dannjjm 2682 4 cobalamin cobalamin NN cord-023095-4dannjjm 2682 5 deficiency deficiency NN cord-023095-4dannjjm 2682 6 have have VBP cord-023095-4dannjjm 2682 7 been be VBN cord-023095-4dannjjm 2682 8 reported report VBN cord-023095-4dannjjm 2682 9 in in IN cord-023095-4dannjjm 2682 10 humans human NNS cord-023095-4dannjjm 2682 11 and and CC cord-023095-4dannjjm 2682 12 may may MD cord-023095-4dannjjm 2682 13 affect affect VB cord-023095-4dannjjm 2682 14 absorption absorption NN cord-023095-4dannjjm 2682 15 , , , cord-023095-4dannjjm 2682 16 transport transport NN cord-023095-4dannjjm 2682 17 , , , cord-023095-4dannjjm 2682 18 or or CC cord-023095-4dannjjm 2682 19 cellular cellular JJ cord-023095-4dannjjm 2682 20 processing processing NN cord-023095-4dannjjm 2682 21 of of IN cord-023095-4dannjjm 2682 22 cobalamin cobalamin NN cord-023095-4dannjjm 2682 23 . . . cord-023095-4dannjjm 2683 1 Based base VBN cord-023095-4dannjjm 2683 2 on on IN cord-023095-4dannjjm 2683 3 human human JJ cord-023095-4dannjjm 2683 4 and and CC cord-023095-4dannjjm 2683 5 veterinary veterinary JJ cord-023095-4dannjjm 2683 6 studies study NNS cord-023095-4dannjjm 2683 7 , , , cord-023095-4dannjjm 2683 8 an an DT cord-023095-4dannjjm 2683 9 increased increase VBN cord-023095-4dannjjm 2683 10 serum serum NN cord-023095-4dannjjm 2683 11 methylmalonic methylmalonic NN cord-023095-4dannjjm 2683 12 acid acid NN cord-023095-4dannjjm 2683 13 ( ( -LRB- cord-023095-4dannjjm 2683 14 MMA MMA NNP cord-023095-4dannjjm 2683 15 ) ) -RRB- cord-023095-4dannjjm 2683 16 concentration concentration NN cord-023095-4dannjjm 2683 17 has have VBZ cord-023095-4dannjjm 2683 18 been be VBN cord-023095-4dannjjm 2683 19 suggested suggest VBN cord-023095-4dannjjm 2683 20 to to TO cord-023095-4dannjjm 2683 21 reflect reflect VB cord-023095-4dannjjm 2683 22 cobalamin cobalamin JJ cord-023095-4dannjjm 2683 23 deficiency deficiency NN cord-023095-4dannjjm 2683 24 at at IN cord-023095-4dannjjm 2683 25 the the DT cord-023095-4dannjjm 2683 26 cellular cellular JJ cord-023095-4dannjjm 2683 27 level level NN cord-023095-4dannjjm 2683 28 . . . cord-023095-4dannjjm 2684 1 In in IN cord-023095-4dannjjm 2684 2 this this DT cord-023095-4dannjjm 2684 3 context context NN cord-023095-4dannjjm 2684 4 , , , cord-023095-4dannjjm 2684 5 it -PRON- PRP cord-023095-4dannjjm 2684 6 has have VBZ cord-023095-4dannjjm 2684 7 been be VBN cord-023095-4dannjjm 2684 8 shown show VBN cord-023095-4dannjjm 2684 9 in in IN cord-023095-4dannjjm 2684 10 humans human NNS cord-023095-4dannjjm 2684 11 that that WDT cord-023095-4dannjjm 2684 12 MMA MMA NNP cord-023095-4dannjjm 2684 13 concentrations concentration NNS cord-023095-4dannjjm 2684 14 are be VBP cord-023095-4dannjjm 2684 15 higher high JJR cord-023095-4dannjjm 2684 16 in in IN cord-023095-4dannjjm 2684 17 patients patient NNS cord-023095-4dannjjm 2684 18 with with IN cord-023095-4dannjjm 2684 19 genetic genetic JJ cord-023095-4dannjjm 2684 20 disorders disorder NNS cord-023095-4dannjjm 2684 21 affecting affect VBG cord-023095-4dannjjm 2684 22 intracellular intracellular JJ cord-023095-4dannjjm 2684 23 processing processing NN cord-023095-4dannjjm 2684 24 than than IN cord-023095-4dannjjm 2684 25 in in IN cord-023095-4dannjjm 2684 26 patients patient NNS cord-023095-4dannjjm 2684 27 with with IN cord-023095-4dannjjm 2684 28 genetic genetic JJ cord-023095-4dannjjm 2684 29 defects defect NNS cord-023095-4dannjjm 2684 30 affecting affect VBG cord-023095-4dannjjm 2684 31 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2684 32 processing processing NN cord-023095-4dannjjm 2684 33 and and CC cord-023095-4dannjjm 2684 34 extracellular extracellular JJ cord-023095-4dannjjm 2684 35 transport transport NN cord-023095-4dannjjm 2684 36 of of IN cord-023095-4dannjjm 2684 37 cobalamin cobalamin NN cord-023095-4dannjjm 2684 38 . . . cord-023095-4dannjjm 2685 1 Therefore therefore RB cord-023095-4dannjjm 2685 2 , , , cord-023095-4dannjjm 2685 3 the the DT cord-023095-4dannjjm 2685 4 aim aim NN cord-023095-4dannjjm 2685 5 of of IN cord-023095-4dannjjm 2685 6 this this DT cord-023095-4dannjjm 2685 7 study study NN cord-023095-4dannjjm 2685 8 was be VBD cord-023095-4dannjjm 2685 9 to to TO cord-023095-4dannjjm 2685 10 evaluate evaluate VB cord-023095-4dannjjm 2685 11 serum serum NN cord-023095-4dannjjm 2685 12 MMA MMA NNP cord-023095-4dannjjm 2685 13 concentrations concentration NNS cord-023095-4dannjjm 2685 14 in in IN cord-023095-4dannjjm 2685 15 Shar Shar NNP cord-023095-4dannjjm 2685 16 Peis Peis NNP cord-023095-4dannjjm 2685 17 and and CC cord-023095-4dannjjm 2685 18 dogs dog NNS cord-023095-4dannjjm 2685 19 of of IN cord-023095-4dannjjm 2685 20 six six CD cord-023095-4dannjjm 2685 21 other other JJ cord-023095-4dannjjm 2685 22 breeds breed NNS cord-023095-4dannjjm 2685 23 with with IN cord-023095-4dannjjm 2685 24 cobalamin cobalamin NN cord-023095-4dannjjm 2685 25 deficiency deficiency NN cord-023095-4dannjjm 2685 26 . . . cord-023095-4dannjjm 2686 1 From from IN cord-023095-4dannjjm 2686 2 2008 2008 CD cord-023095-4dannjjm 2687 1 In in IN cord-023095-4dannjjm 2687 2 conclusion conclusion NN cord-023095-4dannjjm 2687 3 , , , cord-023095-4dannjjm 2687 4 serum serum NN cord-023095-4dannjjm 2687 5 cobalamin cobalamin NN cord-023095-4dannjjm 2687 6 deficient deficient JJ cord-023095-4dannjjm 2687 7 Shar Shar NNP cord-023095-4dannjjm 2687 8 Peis Peis NNP cord-023095-4dannjjm 2687 9 had have VBD cord-023095-4dannjjm 2687 10 a a DT cord-023095-4dannjjm 2687 11 10 10 CD cord-023095-4dannjjm 2687 12 times time NNS cord-023095-4dannjjm 2687 13 higher high JJR cord-023095-4dannjjm 2687 14 median median JJ cord-023095-4dannjjm 2687 15 serum serum NN cord-023095-4dannjjm 2687 16 MMA MMA NNP cord-023095-4dannjjm 2687 17 concentration concentration NN cord-023095-4dannjjm 2687 18 compared compare VBN cord-023095-4dannjjm 2687 19 to to IN cord-023095-4dannjjm 2687 20 cobalamin cobalamin JJ cord-023095-4dannjjm 2687 21 deficient deficient JJ cord-023095-4dannjjm 2687 22 dogs dog NNS cord-023095-4dannjjm 2687 23 of of IN cord-023095-4dannjjm 2687 24 six six CD cord-023095-4dannjjm 2687 25 other other JJ cord-023095-4dannjjm 2687 26 dog dog NN cord-023095-4dannjjm 2687 27 breeds breed NNS cord-023095-4dannjjm 2687 28 . . . cord-023095-4dannjjm 2688 1 Further further JJ cord-023095-4dannjjm 2688 2 studies study NNS cord-023095-4dannjjm 2688 3 are be VBP cord-023095-4dannjjm 2688 4 needed need VBN cord-023095-4dannjjm 2688 5 to to TO cord-023095-4dannjjm 2688 6 investigate investigate VB cord-023095-4dannjjm 2688 7 the the DT cord-023095-4dannjjm 2688 8 intracellular intracellular JJ cord-023095-4dannjjm 2688 9 processing processing NN cord-023095-4dannjjm 2688 10 of of IN cord-023095-4dannjjm 2688 11 cobalamin cobalamin NN cord-023095-4dannjjm 2688 12 in in IN cord-023095-4dannjjm 2688 13 Shar Shar NNP cord-023095-4dannjjm 2688 14 Peis Peis NNP cord-023095-4dannjjm 2688 15 with with IN cord-023095-4dannjjm 2688 16 cobalamin cobalamin NN cord-023095-4dannjjm 2688 17 deficiency deficiency NN cord-023095-4dannjjm 2688 18 . . . cord-023095-4dannjjm 2689 1 Chinese chinese JJ cord-023095-4dannjjm 2689 2 Shar Shar NNP cord-023095-4dannjjm 2689 3 Peis Peis NNP cord-023095-4dannjjm 2689 4 ( ( -LRB- cord-023095-4dannjjm 2689 5 Shar Shar NNP cord-023095-4dannjjm 2689 6 Peis Peis NNP cord-023095-4dannjjm 2689 7 ) ) -RRB- cord-023095-4dannjjm 2689 8 have have VBP cord-023095-4dannjjm 2689 9 a a DT cord-023095-4dannjjm 2689 10 high high JJ cord-023095-4dannjjm 2689 11 prevalence prevalence NN cord-023095-4dannjjm 2689 12 of of IN cord-023095-4dannjjm 2689 13 cobalamin cobalamin NN cord-023095-4dannjjm 2689 14 deficiency deficiency NN cord-023095-4dannjjm 2689 15 . . . cord-023095-4dannjjm 2690 1 Two two CD cord-023095-4dannjjm 2690 2 other other JJ cord-023095-4dannjjm 2690 3 conditions condition NNS cord-023095-4dannjjm 2690 4 reported report VBN cord-023095-4dannjjm 2690 5 frequently frequently RB cord-023095-4dannjjm 2690 6 in in IN cord-023095-4dannjjm 2690 7 this this DT cord-023095-4dannjjm 2690 8 breed breed NN cord-023095-4dannjjm 2690 9 are be VBP cord-023095-4dannjjm 2690 10 Shar Shar NNP cord-023095-4dannjjm 2690 11 Pei Pei NNP cord-023095-4dannjjm 2690 12 fever fever NN cord-023095-4dannjjm 2690 13 and and CC cord-023095-4dannjjm 2690 14 cutaneous cutaneous JJ cord-023095-4dannjjm 2690 15 mucinosis mucinosis NN cord-023095-4dannjjm 2690 16 . . . cord-023095-4dannjjm 2691 1 Shar Shar NNP cord-023095-4dannjjm 2691 2 Pei Pei NNP cord-023095-4dannjjm 2691 3 fever fever NN cord-023095-4dannjjm 2691 4 is be VBZ cord-023095-4dannjjm 2691 5 an an DT cord-023095-4dannjjm 2691 6 autoimmune autoimmune JJ cord-023095-4dannjjm 2691 7 disorder disorder NN cord-023095-4dannjjm 2691 8 causing cause VBG cord-023095-4dannjjm 2691 9 periodic periodic JJ cord-023095-4dannjjm 2691 10 flare flare NN cord-023095-4dannjjm 2691 11 - - HYPH cord-023095-4dannjjm 2691 12 ups up NNS cord-023095-4dannjjm 2691 13 and and CC cord-023095-4dannjjm 2691 14 is be VBZ cord-023095-4dannjjm 2691 15 associated associate VBN cord-023095-4dannjjm 2691 16 with with IN cord-023095-4dannjjm 2691 17 increased increase VBN cord-023095-4dannjjm 2691 18 serum serum NN cord-023095-4dannjjm 2691 19 concentrations concentration NNS cord-023095-4dannjjm 2691 20 of of IN cord-023095-4dannjjm 2691 21 C c NN cord-023095-4dannjjm 2691 22 - - HYPH cord-023095-4dannjjm 2691 23 reactive reactive JJ cord-023095-4dannjjm 2691 24 protein protein NN cord-023095-4dannjjm 2691 25 ( ( -LRB- cord-023095-4dannjjm 2691 26 CRP CRP NNP cord-023095-4dannjjm 2691 27 ) ) -RRB- cord-023095-4dannjjm 2691 28 , , , cord-023095-4dannjjm 2691 29 a a DT cord-023095-4dannjjm 2691 30 nonspecific nonspecific JJ cord-023095-4dannjjm 2691 31 marker marker NN cord-023095-4dannjjm 2691 32 of of IN cord-023095-4dannjjm 2691 33 inflammation inflammation NN cord-023095-4dannjjm 2691 34 . . . cord-023095-4dannjjm 2692 1 Cutaneous cutaneous JJ cord-023095-4dannjjm 2692 2 mucinosis mucinosis NN cord-023095-4dannjjm 2692 3 is be VBZ cord-023095-4dannjjm 2692 4 characterized characterize VBN cord-023095-4dannjjm 2692 5 by by IN cord-023095-4dannjjm 2692 6 excessive excessive JJ cord-023095-4dannjjm 2692 7 deposition deposition NN cord-023095-4dannjjm 2692 8 of of IN cord-023095-4dannjjm 2692 9 mucin mucin NN cord-023095-4dannjjm 2692 10 in in IN cord-023095-4dannjjm 2692 11 the the DT cord-023095-4dannjjm 2692 12 dermis dermis NN cord-023095-4dannjjm 2692 13 . . . cord-023095-4dannjjm 2693 1 Also also RB cord-023095-4dannjjm 2693 2 , , , cord-023095-4dannjjm 2693 3 hyaluronic hyaluronic NN cord-023095-4dannjjm 2693 4 acid acid NN cord-023095-4dannjjm 2693 5 ( ( -LRB- cord-023095-4dannjjm 2693 6 HA HA NNP cord-023095-4dannjjm 2693 7 ) ) -RRB- cord-023095-4dannjjm 2693 8 , , , cord-023095-4dannjjm 2693 9 the the DT cord-023095-4dannjjm 2693 10 main main JJ cord-023095-4dannjjm 2693 11 component component NN cord-023095-4dannjjm 2693 12 of of IN cord-023095-4dannjjm 2693 13 mucin mucin NN cord-023095-4dannjjm 2693 14 , , , cord-023095-4dannjjm 2693 15 was be VBD cord-023095-4dannjjm 2693 16 shown show VBN cord-023095-4dannjjm 2693 17 to to TO cord-023095-4dannjjm 2693 18 be be VB cord-023095-4dannjjm 2693 19 significantly significantly RB cord-023095-4dannjjm 2693 20 higher high JJR cord-023095-4dannjjm 2693 21 in in IN cord-023095-4dannjjm 2693 22 serum serum NN cord-023095-4dannjjm 2693 23 from from IN cord-023095-4dannjjm 2693 24 Shar Shar NNP cord-023095-4dannjjm 2693 25 Peis Peis NNP cord-023095-4dannjjm 2693 26 with with IN cord-023095-4dannjjm 2693 27 cutaneous cutaneous JJ cord-023095-4dannjjm 2693 28 mucinosis mucinosis NN cord-023095-4dannjjm 2693 29 than than IN cord-023095-4dannjjm 2693 30 in in IN cord-023095-4dannjjm 2693 31 healthy healthy JJ cord-023095-4dannjjm 2693 32 controls control NNS cord-023095-4dannjjm 2693 33 . . . cord-023095-4dannjjm 2694 1 To to IN cord-023095-4dannjjm 2694 2 date date NN cord-023095-4dannjjm 2694 3 , , , cord-023095-4dannjjm 2694 4 a a DT cord-023095-4dannjjm 2694 5 possible possible JJ cord-023095-4dannjjm 2694 6 association association NN cord-023095-4dannjjm 2694 7 between between IN cord-023095-4dannjjm 2694 8 Shar Shar NNP cord-023095-4dannjjm 2694 9 Pei Pei NNP cord-023095-4dannjjm 2694 10 fever fever NN cord-023095-4dannjjm 2694 11 and/or and/or CC cord-023095-4dannjjm 2694 12 cutaneous cutaneous JJ cord-023095-4dannjjm 2694 13 mucinosis mucinosis NN cord-023095-4dannjjm 2694 14 on on IN cord-023095-4dannjjm 2694 15 one one CD cord-023095-4dannjjm 2694 16 side side NN cord-023095-4dannjjm 2694 17 and and CC cord-023095-4dannjjm 2694 18 cobalamin cobalamin NN cord-023095-4dannjjm 2694 19 deficiency deficiency NN cord-023095-4dannjjm 2694 20 on on IN cord-023095-4dannjjm 2694 21 the the DT cord-023095-4dannjjm 2694 22 other other JJ cord-023095-4dannjjm 2694 23 has have VBZ cord-023095-4dannjjm 2694 24 not not RB cord-023095-4dannjjm 2694 25 been be VBN cord-023095-4dannjjm 2694 26 investigated investigate VBN cord-023095-4dannjjm 2694 27 in in IN cord-023095-4dannjjm 2694 28 Shar Shar NNP cord-023095-4dannjjm 2694 29 Peis Peis NNP cord-023095-4dannjjm 2694 30 . . . cord-023095-4dannjjm 2695 1 Thus thus RB cord-023095-4dannjjm 2695 2 , , , cord-023095-4dannjjm 2695 3 the the DT cord-023095-4dannjjm 2695 4 aim aim NN cord-023095-4dannjjm 2695 5 of of IN cord-023095-4dannjjm 2695 6 this this DT cord-023095-4dannjjm 2695 7 study study NN cord-023095-4dannjjm 2695 8 was be VBD cord-023095-4dannjjm 2695 9 to to TO cord-023095-4dannjjm 2695 10 compare compare VB cord-023095-4dannjjm 2695 11 serum serum NN cord-023095-4dannjjm 2695 12 concentrations concentration NNS cord-023095-4dannjjm 2695 13 of of IN cord-023095-4dannjjm 2695 14 HA HA NNP cord-023095-4dannjjm 2695 15 ( ( -LRB- cord-023095-4dannjjm 2695 16 an an DT cord-023095-4dannjjm 2695 17 indicator indicator NN cord-023095-4dannjjm 2695 18 of of IN cord-023095-4dannjjm 2695 19 cutaneous cutaneous JJ cord-023095-4dannjjm 2695 20 mucinosis mucinosis NN cord-023095-4dannjjm 2695 21 ) ) -RRB- cord-023095-4dannjjm 2695 22 and and CC cord-023095-4dannjjm 2695 23 inflammatory inflammatory JJ cord-023095-4dannjjm 2695 24 markers marker NNS cord-023095-4dannjjm 2695 25 ( ( -LRB- cord-023095-4dannjjm 2695 26 CRP CRP NNP cord-023095-4dannjjm 2695 27 , , , cord-023095-4dannjjm 2695 28 calprotectin calprotectin NNP cord-023095-4dannjjm 2695 29 , , , cord-023095-4dannjjm 2695 30 and and CC cord-023095-4dannjjm 2695 31 S100A12 s100a12 CD cord-023095-4dannjjm 2695 32 ) ) -RRB- cord-023095-4dannjjm 2695 33 , , , cord-023095-4dannjjm 2695 34 assumed assume VBN cord-023095-4dannjjm 2695 35 to to TO cord-023095-4dannjjm 2695 36 be be VB cord-023095-4dannjjm 2695 37 increased increase VBN cord-023095-4dannjjm 2695 38 in in IN cord-023095-4dannjjm 2695 39 episodes episode NNS cord-023095-4dannjjm 2695 40 of of IN cord-023095-4dannjjm 2695 41 Shar Shar NNP cord-023095-4dannjjm 2695 42 Pei Pei NNP cord-023095-4dannjjm 2695 43 fever fever NN cord-023095-4dannjjm 2695 44 , , , cord-023095-4dannjjm 2695 45 in in IN cord-023095-4dannjjm 2695 46 Shar Shar NNP cord-023095-4dannjjm 2695 47 Peis Peis NNP cord-023095-4dannjjm 2695 48 with with IN cord-023095-4dannjjm 2695 49 and and CC cord-023095-4dannjjm 2695 50 without without IN cord-023095-4dannjjm 2695 51 cobalamin cobalamin NN cord-023095-4dannjjm 2695 52 deficiency deficiency NN cord-023095-4dannjjm 2695 53 . . . cord-023095-4dannjjm 2696 1 Serum serum NN cord-023095-4dannjjm 2696 2 samples sample NNS cord-023095-4dannjjm 2696 3 from from IN cord-023095-4dannjjm 2696 4 40 40 CD cord-023095-4dannjjm 2696 5 Shar Shar NNP cord-023095-4dannjjm 2696 6 Peis Peis NNP cord-023095-4dannjjm 2696 7 , , , cord-023095-4dannjjm 2696 8 collected collect VBN cord-023095-4dannjjm 2696 9 from from IN cord-023095-4dannjjm 2696 10 2008 2008 CD cord-023095-4dannjjm 2696 11 to to IN cord-023095-4dannjjm 2696 12 2010 2010 CD cord-023095-4dannjjm 2696 13 , , , cord-023095-4dannjjm 2696 14 were be VBD cord-023095-4dannjjm 2696 15 analyzed analyze VBN cord-023095-4dannjjm 2696 16 . . . cord-023095-4dannjjm 2697 1 Serum serum NN cord-023095-4dannjjm 2697 2 HA HA NNP cord-023095-4dannjjm 2697 3 and and CC cord-023095-4dannjjm 2697 4 CRP CRP NNP cord-023095-4dannjjm 2697 5 ( ( -LRB- cord-023095-4dannjjm 2697 6 reference reference NN cord-023095-4dannjjm 2697 7 interval interval NN cord-023095-4dannjjm 2697 8 ( ( -LRB- cord-023095-4dannjjm 2697 9 RI RI NNP cord-023095-4dannjjm 2697 10 ) ) -RRB- cord-023095-4dannjjm 2697 11 : : : cord-023095-4dannjjm 2697 12 0.0 0.0 CD cord-023095-4dannjjm 2697 13 - - SYM cord-023095-4dannjjm 2697 14 7.6 7.6 CD cord-023095-4dannjjm 2697 15 mg mg NNP cord-023095-4dannjjm 2697 16 / / SYM cord-023095-4dannjjm 2697 17 L L NNP cord-023095-4dannjjm 2697 18 ) ) -RRB- cord-023095-4dannjjm 2697 19 were be VBD cord-023095-4dannjjm 2697 20 quantified quantify VBN cord-023095-4dannjjm 2697 21 by by IN cord-023095-4dannjjm 2697 22 using use VBG cord-023095-4dannjjm 2697 23 commercial commercial JJ cord-023095-4dannjjm 2697 24 ELISA ELISA NNP cord-023095-4dannjjm 2697 25 kits kit NNS cord-023095-4dannjjm 2697 26 ( ( -LRB- cord-023095-4dannjjm 2697 27 Echelon Echelon NNP cord-023095-4dannjjm 2697 28 Biosciences Biosciences NNP cord-023095-4dannjjm 2697 29 , , , cord-023095-4dannjjm 2697 30 Salt Salt NNP cord-023095-4dannjjm 2697 31 Lake Lake NNP cord-023095-4dannjjm 2697 32 City City NNP cord-023095-4dannjjm 2697 33 , , , cord-023095-4dannjjm 2697 34 UT UT NNP cord-023095-4dannjjm 2697 35 , , , cord-023095-4dannjjm 2697 36 USA USA NNP cord-023095-4dannjjm 2697 37 and and CC cord-023095-4dannjjm 2697 38 Tridelta Tridelta NNP cord-023095-4dannjjm 2697 39 , , , cord-023095-4dannjjm 2697 40 Maynooth Maynooth NNP cord-023095-4dannjjm 2697 41 , , , cord-023095-4dannjjm 2697 42 Ireland Ireland NNP cord-023095-4dannjjm 2697 43 ; ; : cord-023095-4dannjjm 2697 44 respectively respectively RB cord-023095-4dannjjm 2697 45 ) ) -RRB- cord-023095-4dannjjm 2697 46 . . . cord-023095-4dannjjm 2698 1 Serum serum NN cord-023095-4dannjjm 2698 2 calgranulin calgranulin NN cord-023095-4dannjjm 2698 3 concentrations concentration NNS cord-023095-4dannjjm 2698 4 were be VBD cord-023095-4dannjjm 2698 5 measured measure VBN cord-023095-4dannjjm 2698 6 using use VBG cord-023095-4dannjjm 2698 7 an an DT cord-023095-4dannjjm 2698 8 in in IN cord-023095-4dannjjm 2698 9 - - HYPH cord-023095-4dannjjm 2698 10 house house NN cord-023095-4dannjjm 2698 11 ELISA ELISA NNP cord-023095-4dannjjm 2698 12 ( ( -LRB- cord-023095-4dannjjm 2698 13 calprotectin calprotectin NNP cord-023095-4dannjjm 2698 14 ; ; : cord-023095-4dannjjm 2698 15 RI RI NNP cord-023095-4dannjjm 2698 16 : : : cord-023095-4dannjjm 2698 17 0.9 0.9 CD cord-023095-4dannjjm 2698 18 - - SYM cord-023095-4dannjjm 2698 19 11.9 11.9 CD cord-023095-4dannjjm 2698 20 mg mg NNP cord-023095-4dannjjm 2698 21 / / SYM cord-023095-4dannjjm 2698 22 L L NNP cord-023095-4dannjjm 2698 23 ) ) -RRB- cord-023095-4dannjjm 2698 24 and and CC cord-023095-4dannjjm 2698 25 RIA RIA NNP cord-023095-4dannjjm 2698 26 ( ( -LRB- cord-023095-4dannjjm 2698 27 S100A12 s100a12 NN cord-023095-4dannjjm 2698 28 ; ; : cord-023095-4dannjjm 2698 29 RI RI NNP cord-023095-4dannjjm 2698 30 : : : cord-023095-4dannjjm 2698 31 33.0 33.0 CD cord-023095-4dannjjm 2698 32 - - SYM cord-023095-4dannjjm 2698 33 233.0 233.0 CD cord-023095-4dannjjm 2698 34 mg mg NNP cord-023095-4dannjjm 2698 35 / / SYM cord-023095-4dannjjm 2698 36 L L NNP cord-023095-4dannjjm 2698 37 ) ) -RRB- cord-023095-4dannjjm 2698 38 , , , cord-023095-4dannjjm 2698 39 respectively respectively RB cord-023095-4dannjjm 2698 40 . . . cord-023095-4dannjjm 2699 1 Mann Mann NNP cord-023095-4dannjjm 2699 2 - - HYPH cord-023095-4dannjjm 2699 3 Whitney Whitney NNP cord-023095-4dannjjm 2699 4 U U NNP cord-023095-4dannjjm 2699 5 tests test NNS cord-023095-4dannjjm 2699 6 were be VBD cord-023095-4dannjjm 2699 7 used use VBN cord-023095-4dannjjm 2699 8 to to TO cord-023095-4dannjjm 2699 9 compare compare VB cord-023095-4dannjjm 2699 10 serum serum NN cord-023095-4dannjjm 2699 11 HA HA NNP cord-023095-4dannjjm 2699 12 , , , cord-023095-4dannjjm 2699 13 CRP CRP NNP cord-023095-4dannjjm 2699 14 , , , cord-023095-4dannjjm 2699 15 calprotectin calprotectin NNP cord-023095-4dannjjm 2699 16 , , , cord-023095-4dannjjm 2699 17 and and CC cord-023095-4dannjjm 2699 18 S100A12 s100a12 NN cord-023095-4dannjjm 2699 19 concentrations concentration NNS cord-023095-4dannjjm 2699 20 between between IN cord-023095-4dannjjm 2699 21 Shar Shar NNP cord-023095-4dannjjm 2699 22 Peis Peis NNP cord-023095-4dannjjm 2699 23 with with IN cord-023095-4dannjjm 2699 24 and and CC cord-023095-4dannjjm 2699 25 without without IN cord-023095-4dannjjm 2699 26 cobalamin cobalamin NN cord-023095-4dannjjm 2699 27 deficiency deficiency NN cord-023095-4dannjjm 2699 28 . . . cord-023095-4dannjjm 2700 1 Significance significance NN cord-023095-4dannjjm 2700 2 was be VBD cord-023095-4dannjjm 2700 3 set set VBN cord-023095-4dannjjm 2700 4 at at IN cord-023095-4dannjjm 2700 5 p p NN cord-023095-4dannjjm 2700 6 o o NN cord-023095-4dannjjm 2700 7 0.05 0.05 CD cord-023095-4dannjjm 2700 8 . . . cord-023095-4dannjjm 2701 1 Fourteen fourteen CD cord-023095-4dannjjm 2701 2 Shar Shar NNP cord-023095-4dannjjm 2701 3 Peis Peis NNP cord-023095-4dannjjm 2701 4 were be VBD cord-023095-4dannjjm 2701 5 severely severely RB cord-023095-4dannjjm 2701 6 cobalamin cobalamin JJ cord-023095-4dannjjm 2701 7 deficient deficient JJ cord-023095-4dannjjm 2701 8 , , , cord-023095-4dannjjm 2701 9 defined define VBN cord-023095-4dannjjm 2701 10 by by IN cord-023095-4dannjjm 2701 11 an an DT cord-023095-4dannjjm 2701 12 undetectable undetectable JJ cord-023095-4dannjjm 2701 13 serum serum NN cord-023095-4dannjjm 2701 14 cobalamin cobalamin NN cord-023095-4dannjjm 2701 15 concentration concentration NN cord-023095-4dannjjm 2701 16 ( ( -LRB- cord-023095-4dannjjm 2701 17 o o UH cord-023095-4dannjjm 2701 18 150 150 CD cord-023095-4dannjjm 2701 19 ng ng NN cord-023095-4dannjjm 2701 20 / / SYM cord-023095-4dannjjm 2701 21 L L NNP cord-023095-4dannjjm 2701 22 ) ) -RRB- cord-023095-4dannjjm 2701 23 . . . cord-023095-4dannjjm 2702 1 In in IN cord-023095-4dannjjm 2702 2 the the DT cord-023095-4dannjjm 2702 3 remaining remain VBG cord-023095-4dannjjm 2702 4 26 26 CD cord-023095-4dannjjm 2702 5 dogs dog NNS cord-023095-4dannjjm 2702 6 , , , cord-023095-4dannjjm 2702 7 serum serum NN cord-023095-4dannjjm 2702 8 cobalamin cobalamin NN cord-023095-4dannjjm 2702 9 concentrations concentration NNS cord-023095-4dannjjm 2702 10 were be VBD cord-023095-4dannjjm 2702 11 within within IN cord-023095-4dannjjm 2702 12 the the DT cord-023095-4dannjjm 2702 13 reference reference NN cord-023095-4dannjjm 2702 14 interval interval NN cord-023095-4dannjjm 2702 15 ( ( -LRB- cord-023095-4dannjjm 2702 16 251 251 CD cord-023095-4dannjjm 2702 17 - - SYM cord-023095-4dannjjm 2702 18 908 908 CD cord-023095-4dannjjm 2702 19 ng ng NNP cord-023095-4dannjjm 2702 20 / / SYM cord-023095-4dannjjm 2702 21 L L NNP cord-023095-4dannjjm 2702 22 ) ) -RRB- cord-023095-4dannjjm 2702 23 . . . cord-023095-4dannjjm 2703 1 Serum serum NN cord-023095-4dannjjm 2703 2 concentrations concentration NNS cord-023095-4dannjjm 2703 3 of of IN cord-023095-4dannjjm 2703 4 HA HA NNP cord-023095-4dannjjm 2703 5 , , , cord-023095-4dannjjm 2703 6 CRP CRP NNP cord-023095-4dannjjm 2703 7 , , , cord-023095-4dannjjm 2703 8 calprotectin calprotectin NNP cord-023095-4dannjjm 2703 9 , , , cord-023095-4dannjjm 2703 10 and and CC cord-023095-4dannjjm 2703 11 S100A12 S100A12 NNS cord-023095-4dannjjm 2703 12 were be VBD cord-023095-4dannjjm 2703 13 not not RB cord-023095-4dannjjm 2703 14 significantly significantly RB cord-023095-4dannjjm 2703 15 different different JJ cord-023095-4dannjjm 2703 16 between between IN cord-023095-4dannjjm 2703 17 cobalamin cobalamin NN cord-023095-4dannjjm 2703 18 deficient deficient JJ cord-023095-4dannjjm 2703 19 Shar Shar NNP cord-023095-4dannjjm 2703 20 Peis Peis NNP cord-023095-4dannjjm 2703 21 ( ( -LRB- cord-023095-4dannjjm 2703 22 medians median NNS cord-023095-4dannjjm 2703 23 : : : cord-023095-4dannjjm 2703 24 649.9 649.9 CD cord-023095-4dannjjm 2703 25 ng ng NN cord-023095-4dannjjm 2703 26 / / SYM cord-023095-4dannjjm 2703 27 ml ml NN cord-023095-4dannjjm 2703 28 , , , cord-023095-4dannjjm 2703 29 4 4 CD cord-023095-4dannjjm 2703 30 . . . cord-023095-4dannjjm 2703 31 . . . cord-023095-4dannjjm 2704 1 Fifty fifty CD cord-023095-4dannjjm 2704 2 percent percent NN cord-023095-4dannjjm 2704 3 of of IN cord-023095-4dannjjm 2704 4 cobalamin cobalamin NN cord-023095-4dannjjm 2704 5 deficient deficient JJ cord-023095-4dannjjm 2704 6 Shar Shar NNP cord-023095-4dannjjm 2704 7 Peis Peis NNP cord-023095-4dannjjm 2704 8 had have VBD cord-023095-4dannjjm 2704 9 serum serum NN cord-023095-4dannjjm 2704 10 calprotectin calprotectin NN cord-023095-4dannjjm 2704 11 concentrations concentration NNS cord-023095-4dannjjm 2704 12 above above IN cord-023095-4dannjjm 2704 13 the the DT cord-023095-4dannjjm 2704 14 upper upper JJ cord-023095-4dannjjm 2704 15 limit limit NN cord-023095-4dannjjm 2704 16 of of IN cord-023095-4dannjjm 2704 17 the the DT cord-023095-4dannjjm 2704 18 reference reference NN cord-023095-4dannjjm 2704 19 interval interval NN cord-023095-4dannjjm 2704 20 , , , cord-023095-4dannjjm 2704 21 and and CC cord-023095-4dannjjm 2704 22 43 43 CD cord-023095-4dannjjm 2704 23 % % NN cord-023095-4dannjjm 2704 24 had have VBD cord-023095-4dannjjm 2704 25 serum serum NN cord-023095-4dannjjm 2704 26 S100A12 s100a12 NN cord-023095-4dannjjm 2704 27 concentrations concentration NNS cord-023095-4dannjjm 2704 28 above above IN cord-023095-4dannjjm 2704 29 the the DT cord-023095-4dannjjm 2704 30 suggested suggest VBN cord-023095-4dannjjm 2704 31 upper upper JJ cord-023095-4dannjjm 2704 32 reference reference NN cord-023095-4dannjjm 2704 33 limit limit NN cord-023095-4dannjjm 2704 34 . . . cord-023095-4dannjjm 2705 1 In in IN cord-023095-4dannjjm 2705 2 this this DT cord-023095-4dannjjm 2705 3 study study NN cord-023095-4dannjjm 2705 4 , , , cord-023095-4dannjjm 2705 5 serum serum NN cord-023095-4dannjjm 2705 6 concentrations concentration NNS cord-023095-4dannjjm 2705 7 of of IN cord-023095-4dannjjm 2705 8 HA HA NNP cord-023095-4dannjjm 2705 9 , , , cord-023095-4dannjjm 2705 10 CRP CRP NNP cord-023095-4dannjjm 2705 11 , , , cord-023095-4dannjjm 2705 12 and and CC cord-023095-4dannjjm 2705 13 the the DT cord-023095-4dannjjm 2705 14 calgranulins calgranulin NNS cord-023095-4dannjjm 2705 15 did do VBD cord-023095-4dannjjm 2705 16 not not RB cord-023095-4dannjjm 2705 17 differ differ VB cord-023095-4dannjjm 2705 18 between between IN cord-023095-4dannjjm 2705 19 cobalamin cobalamin NN cord-023095-4dannjjm 2705 20 deficient deficient JJ cord-023095-4dannjjm 2705 21 Shar Shar NNP cord-023095-4dannjjm 2705 22 Peis Peis NNP cord-023095-4dannjjm 2705 23 and and CC cord-023095-4dannjjm 2705 24 Shar Shar NNP cord-023095-4dannjjm 2705 25 Peis Peis NNP cord-023095-4dannjjm 2705 26 with with IN cord-023095-4dannjjm 2705 27 a a DT cord-023095-4dannjjm 2705 28 normal normal JJ cord-023095-4dannjjm 2705 29 serum serum NN cord-023095-4dannjjm 2705 30 cobalamin cobalamin NN cord-023095-4dannjjm 2705 31 concentration concentration NN cord-023095-4dannjjm 2705 32 . . . cord-023095-4dannjjm 2706 1 This this DT cord-023095-4dannjjm 2706 2 finding finding NN cord-023095-4dannjjm 2706 3 leads lead VBZ cord-023095-4dannjjm 2706 4 us -PRON- PRP cord-023095-4dannjjm 2706 5 to to TO cord-023095-4dannjjm 2706 6 speculate speculate VB cord-023095-4dannjjm 2706 7 that that IN cord-023095-4dannjjm 2706 8 increased increase VBD cord-023095-4dannjjm 2706 9 HA HA NNP cord-023095-4dannjjm 2706 10 and/or and/or CC cord-023095-4dannjjm 2706 11 inflammatory inflammatory JJ cord-023095-4dannjjm 2706 12 markers marker NNS cord-023095-4dannjjm 2706 13 are be VBP cord-023095-4dannjjm 2706 14 not not RB cord-023095-4dannjjm 2706 15 associated associate VBN cord-023095-4dannjjm 2706 16 with with IN cord-023095-4dannjjm 2706 17 cobalamin cobalamin NN cord-023095-4dannjjm 2706 18 deficiency deficiency NN cord-023095-4dannjjm 2706 19 in in IN cord-023095-4dannjjm 2706 20 Shar Shar NNP cord-023095-4dannjjm 2706 21 Peis Peis NNP cord-023095-4dannjjm 2706 22 . . . cord-023095-4dannjjm 2707 1 Further further JJ cord-023095-4dannjjm 2707 2 studies study NNS cord-023095-4dannjjm 2707 3 are be VBP cord-023095-4dannjjm 2707 4 needed need VBN cord-023095-4dannjjm 2707 5 to to TO cord-023095-4dannjjm 2707 6 investigate investigate VB cord-023095-4dannjjm 2707 7 serum serum NN cord-023095-4dannjjm 2707 8 cobalamin cobalamin NN cord-023095-4dannjjm 2707 9 concentrations concentration NNS cord-023095-4dannjjm 2707 10 in in IN cord-023095-4dannjjm 2707 11 patients patient NNS cord-023095-4dannjjm 2707 12 with with IN cord-023095-4dannjjm 2707 13 Shar Shar NNP cord-023095-4dannjjm 2707 14 Pei Pei NNP cord-023095-4dannjjm 2707 15 fever fever NN cord-023095-4dannjjm 2707 16 or or CC cord-023095-4dannjjm 2707 17 cutaneous cutaneous JJ cord-023095-4dannjjm 2707 18 mucinosis mucinosis NN cord-023095-4dannjjm 2707 19 . . . cord-023095-4dannjjm 2708 1 Cobalamin Cobalamin NNP cord-023095-4dannjjm 2708 2 deficiency deficiency NN cord-023095-4dannjjm 2708 3 ( ( -LRB- cord-023095-4dannjjm 2708 4 CD CD NNP cord-023095-4dannjjm 2708 5 ) ) -RRB- cord-023095-4dannjjm 2708 6 has have VBZ cord-023095-4dannjjm 2708 7 been be VBN cord-023095-4dannjjm 2708 8 associated associate VBN cord-023095-4dannjjm 2708 9 with with IN cord-023095-4dannjjm 2708 10 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2708 11 and and CC cord-023095-4dannjjm 2708 12 pancreatic pancreatic JJ cord-023095-4dannjjm 2708 13 disease disease NN cord-023095-4dannjjm 2708 14 in in IN cord-023095-4dannjjm 2708 15 dogs dog NNS cord-023095-4dannjjm 2708 16 . . . cord-023095-4dannjjm 2709 1 Hereditary hereditary JJ cord-023095-4dannjjm 2709 2 CD CD NNP cord-023095-4dannjjm 2709 3 has have VBZ cord-023095-4dannjjm 2709 4 been be VBN cord-023095-4dannjjm 2709 5 demonstrated demonstrate VBN cord-023095-4dannjjm 2709 6 in in IN cord-023095-4dannjjm 2709 7 Giant Giant NNP cord-023095-4dannjjm 2709 8 Schnauzers Schnauzers NNPS cord-023095-4dannjjm 2709 9 and and CC cord-023095-4dannjjm 2710 1 single single JJ cord-023095-4dannjjm 2710 2 case case NN cord-023095-4dannjjm 2710 3 reports report NNS cord-023095-4dannjjm 2710 4 have have VBP cord-023095-4dannjjm 2710 5 suggested suggest VBN cord-023095-4dannjjm 2710 6 congenital congenital JJ cord-023095-4dannjjm 2710 7 CD cd NN cord-023095-4dannjjm 2710 8 in in IN cord-023095-4dannjjm 2710 9 the the DT cord-023095-4dannjjm 2710 10 Border Border NNP cord-023095-4dannjjm 2710 11 Collie Collie NNP cord-023095-4dannjjm 2710 12 ( ( -LRB- cord-023095-4dannjjm 2710 13 BC BC NNP cord-023095-4dannjjm 2710 14 ) ) -RRB- cord-023095-4dannjjm 2710 15 breed breed NN cord-023095-4dannjjm 2710 16 . . . cord-023095-4dannjjm 2711 1 Clinicopathologic Clinicopathologic NNP cord-023095-4dannjjm 2711 2 findings finding NNS cord-023095-4dannjjm 2711 3 of of IN cord-023095-4dannjjm 2711 4 CD CD NNP cord-023095-4dannjjm 2711 5 vary vary VBP cord-023095-4dannjjm 2711 6 and and CC cord-023095-4dannjjm 2711 7 can can MD cord-023095-4dannjjm 2711 8 be be VB cord-023095-4dannjjm 2711 9 unspecific unspecific JJ cord-023095-4dannjjm 2711 10 as as IN cord-023095-4dannjjm 2711 11 cobalamin cobalamin NN cord-023095-4dannjjm 2711 12 acts act VBZ cord-023095-4dannjjm 2711 13 as as IN cord-023095-4dannjjm 2711 14 a a DT cord-023095-4dannjjm 2711 15 Co co NN cord-023095-4dannjjm 2711 16 - - NN cord-023095-4dannjjm 2711 17 Factor factor NN cord-023095-4dannjjm 2711 18 for for IN cord-023095-4dannjjm 2711 19 a a DT cord-023095-4dannjjm 2711 20 multitude multitude NN cord-023095-4dannjjm 2711 21 of of IN cord-023095-4dannjjm 2711 22 enzymatic enzymatic JJ cord-023095-4dannjjm 2711 23 reactions reaction NNS cord-023095-4dannjjm 2711 24 . . . cord-023095-4dannjjm 2712 1 The the DT cord-023095-4dannjjm 2712 2 two two CD cord-023095-4dannjjm 2712 3 most most RBS cord-023095-4dannjjm 2712 4 important important JJ cord-023095-4dannjjm 2712 5 reactions reaction NNS cord-023095-4dannjjm 2712 6 concern concern VBP cord-023095-4dannjjm 2712 7 the the DT cord-023095-4dannjjm 2712 8 conversion conversion NN cord-023095-4dannjjm 2712 9 of of IN cord-023095-4dannjjm 2712 10 methylmalonyl methylmalonyl NNP cord-023095-4dannjjm 2712 11 - - HYPH cord-023095-4dannjjm 2712 12 CoA CoA NNP cord-023095-4dannjjm 2712 13 to to IN cord-023095-4dannjjm 2712 14 succinyl succinyl NNP cord-023095-4dannjjm 2712 15 - - HYPH cord-023095-4dannjjm 2712 16 CoA CoA NNP cord-023095-4dannjjm 2712 17 and and CC cord-023095-4dannjjm 2712 18 the the DT cord-023095-4dannjjm 2712 19 re re NN cord-023095-4dannjjm 2712 20 - - NN cord-023095-4dannjjm 2712 21 methylation methylation NN cord-023095-4dannjjm 2712 22 of of IN cord-023095-4dannjjm 2712 23 homocysteine homocysteine NN cord-023095-4dannjjm 2712 24 ( ( -LRB- cord-023095-4dannjjm 2712 25 Hcy Hcy NNP cord-023095-4dannjjm 2712 26 ) ) -RRB- cord-023095-4dannjjm 2712 27 . . . cord-023095-4dannjjm 2713 1 These these DT cord-023095-4dannjjm 2713 2 two two CD cord-023095-4dannjjm 2713 3 metabolites metabolite NNS cord-023095-4dannjjm 2713 4 increase increase VBP cord-023095-4dannjjm 2713 5 when when WRB cord-023095-4dannjjm 2713 6 cobalamin cobalamin NN cord-023095-4dannjjm 2713 7 is be VBZ cord-023095-4dannjjm 2713 8 lacking lack VBG cord-023095-4dannjjm 2713 9 and and CC cord-023095-4dannjjm 2713 10 act act VB cord-023095-4dannjjm 2713 11 as as IN cord-023095-4dannjjm 2713 12 markers marker NNS cord-023095-4dannjjm 2713 13 for for IN cord-023095-4dannjjm 2713 14 cobalamin cobalamin NN cord-023095-4dannjjm 2713 15 availability availability NN cord-023095-4dannjjm 2713 16 on on IN cord-023095-4dannjjm 2713 17 a a DT cord-023095-4dannjjm 2713 18 cellular cellular JJ cord-023095-4dannjjm 2713 19 level level NN cord-023095-4dannjjm 2713 20 . . . cord-023095-4dannjjm 2714 1 Preliminary preliminary JJ cord-023095-4dannjjm 2714 2 data datum NNS cord-023095-4dannjjm 2714 3 from from IN cord-023095-4dannjjm 2714 4 dogs dog NNS cord-023095-4dannjjm 2714 5 suggested suggest VBD cord-023095-4dannjjm 2714 6 that that IN cord-023095-4dannjjm 2714 7 measurement measurement NN cord-023095-4dannjjm 2714 8 of of IN cord-023095-4dannjjm 2714 9 methylmalonic methylmalonic NNP cord-023095-4dannjjm 2714 10 acid acid NNP cord-023095-4dannjjm 2714 11 ( ( -LRB- cord-023095-4dannjjm 2714 12 MMA MMA NNP cord-023095-4dannjjm 2714 13 ) ) -RRB- cord-023095-4dannjjm 2714 14 may may MD cord-023095-4dannjjm 2714 15 be be VB cord-023095-4dannjjm 2714 16 a a DT cord-023095-4dannjjm 2714 17 better well RBR cord-023095-4dannjjm 2714 18 diagnostic diagnostic JJ cord-023095-4dannjjm 2714 19 test test NN cord-023095-4dannjjm 2714 20 for for IN cord-023095-4dannjjm 2714 21 CD CD NNP cord-023095-4dannjjm 2714 22 than than IN cord-023095-4dannjjm 2714 23 serum serum NN cord-023095-4dannjjm 2714 24 cobalamin cobalamin NN cord-023095-4dannjjm 2714 25 concentration concentration NN cord-023095-4dannjjm 2714 26 . . . cord-023095-4dannjjm 2715 1 Therefore therefore RB cord-023095-4dannjjm 2715 2 the the DT cord-023095-4dannjjm 2715 3 goals goal NNS cord-023095-4dannjjm 2715 4 of of IN cord-023095-4dannjjm 2715 5 the the DT cord-023095-4dannjjm 2715 6 study study NN cord-023095-4dannjjm 2715 7 were be VBD cord-023095-4dannjjm 2715 8 ( ( -LRB- cord-023095-4dannjjm 2715 9 1 1 CD cord-023095-4dannjjm 2715 10 ) ) -RRB- cord-023095-4dannjjm 2715 11 to to TO cord-023095-4dannjjm 2715 12 establish establish VB cord-023095-4dannjjm 2715 13 reference reference NN cord-023095-4dannjjm 2715 14 values value NNS cord-023095-4dannjjm 2715 15 for for IN cord-023095-4dannjjm 2715 16 serum serum NN cord-023095-4dannjjm 2715 17 cobalamin cobalamin NN cord-023095-4dannjjm 2715 18 , , , cord-023095-4dannjjm 2715 19 urine urine NN cord-023095-4dannjjm 2715 20 MMA MMA NNP cord-023095-4dannjjm 2715 21 and and CC cord-023095-4dannjjm 2715 22 plasma plasma NN cord-023095-4dannjjm 2715 23 Hcy Hcy NNP cord-023095-4dannjjm 2715 24 in in IN cord-023095-4dannjjm 2715 25 healthy healthy JJ cord-023095-4dannjjm 2715 26 pet pet JJ cord-023095-4dannjjm 2715 27 dogs dog NNS cord-023095-4dannjjm 2715 28 , , , cord-023095-4dannjjm 2715 29 ( ( -LRB- cord-023095-4dannjjm 2715 30 2 2 LS cord-023095-4dannjjm 2715 31 ) ) -RRB- cord-023095-4dannjjm 2715 32 to to TO cord-023095-4dannjjm 2715 33 screen screen VB cord-023095-4dannjjm 2715 34 a a DT cord-023095-4dannjjm 2715 35 larger large JJR cord-023095-4dannjjm 2715 36 BC BC NNP cord-023095-4dannjjm 2715 37 population population NN cord-023095-4dannjjm 2715 38 from from IN cord-023095-4dannjjm 2715 39 Switzerland Switzerland NNP cord-023095-4dannjjm 2715 40 for for IN cord-023095-4dannjjm 2715 41 CD CD NNP cord-023095-4dannjjm 2715 42 , , , cord-023095-4dannjjm 2715 43 and and CC cord-023095-4dannjjm 2715 44 ( ( -LRB- cord-023095-4dannjjm 2715 45 3 3 LS cord-023095-4dannjjm 2715 46 ) ) -RRB- cord-023095-4dannjjm 2715 47 to to TO cord-023095-4dannjjm 2715 48 perform perform VB cord-023095-4dannjjm 2715 49 genomic genomic JJ cord-023095-4dannjjm 2715 50 analyses analysis NNS cord-023095-4dannjjm 2715 51 on on IN cord-023095-4dannjjm 2715 52 BC BC NNP cord-023095-4dannjjm 2715 53 with with IN cord-023095-4dannjjm 2715 54 CD CD NNP cord-023095-4dannjjm 2715 55 . . . cord-023095-4dannjjm 2716 1 For for IN cord-023095-4dannjjm 2716 2 determination determination NN cord-023095-4dannjjm 2716 3 of of IN cord-023095-4dannjjm 2716 4 reference reference NN cord-023095-4dannjjm 2716 5 values value NNS cord-023095-4dannjjm 2716 6 35 35 CD cord-023095-4dannjjm 2716 7 healthy healthy JJ cord-023095-4dannjjm 2716 8 pet pet JJ cord-023095-4dannjjm 2716 9 dogs dog NNS cord-023095-4dannjjm 2716 10 were be VBD cord-023095-4dannjjm 2716 11 used use VBN cord-023095-4dannjjm 2716 12 . . . cord-023095-4dannjjm 2717 1 Serum serum NN cord-023095-4dannjjm 2717 2 cobalamin cobalamin NN cord-023095-4dannjjm 2717 3 was be VBD cord-023095-4dannjjm 2717 4 measured measure VBN cord-023095-4dannjjm 2717 5 using use VBG cord-023095-4dannjjm 2717 6 an an DT cord-023095-4dannjjm 2717 7 automated automate VBN cord-023095-4dannjjm 2717 8 chemiluminescence chemiluminescence NN cord-023095-4dannjjm 2717 9 assay assay NN cord-023095-4dannjjm 2717 10 ( ( -LRB- cord-023095-4dannjjm 2717 11 Immulite Immulite NNP cord-023095-4dannjjm 2717 12 2000 2000 CD cord-023095-4dannjjm 2717 13 ) ) -RRB- cord-023095-4dannjjm 2717 14 , , , cord-023095-4dannjjm 2717 15 urine urine NN cord-023095-4dannjjm 2717 16 MMA MMA NNP cord-023095-4dannjjm 2717 17 was be VBD cord-023095-4dannjjm 2717 18 determined determine VBN cord-023095-4dannjjm 2717 19 using use VBG cord-023095-4dannjjm 2717 20 gas gas NN cord-023095-4dannjjm 2717 21 chromatography chromatography NN cord-023095-4dannjjm 2717 22 and and CC cord-023095-4dannjjm 2717 23 expressed express VBD cord-023095-4dannjjm 2717 24 as as IN cord-023095-4dannjjm 2717 25 a a DT cord-023095-4dannjjm 2717 26 ratio ratio NN cord-023095-4dannjjm 2717 27 to to TO cord-023095-4dannjjm 2717 28 urine urine NN cord-023095-4dannjjm 2717 29 creatinine creatinine NN cord-023095-4dannjjm 2717 30 and and CC cord-023095-4dannjjm 2718 1 plasma plasma NNP cord-023095-4dannjjm 2718 2 Hcy Hcy NNP cord-023095-4dannjjm 2718 3 was be VBD cord-023095-4dannjjm 2718 4 measured measure VBN cord-023095-4dannjjm 2718 5 using use VBG cord-023095-4dannjjm 2718 6 High High NNP cord-023095-4dannjjm 2718 7 Pressure Pressure NNP cord-023095-4dannjjm 2718 8 Liquid Liquid NNP cord-023095-4dannjjm 2718 9 Chromatography Chromatography NNP cord-023095-4dannjjm 2718 10 and and CC cord-023095-4dannjjm 2718 11 fluorimetric fluorimetric JJ cord-023095-4dannjjm 2718 12 detection detection NN cord-023095-4dannjjm 2718 13 . . . cord-023095-4dannjjm 2719 1 To to TO cord-023095-4dannjjm 2719 2 calculate calculate VB cord-023095-4dannjjm 2719 3 reference reference NN cord-023095-4dannjjm 2719 4 ranges range VBZ cord-023095-4dannjjm 2719 5 the the DT cord-023095-4dannjjm 2719 6 10th 10th JJ cord-023095-4dannjjm 2719 7 and and CC cord-023095-4dannjjm 2719 8 90th 90th JJ cord-023095-4dannjjm 2719 9 percentile percentile NN cord-023095-4dannjjm 2719 10 were be VBD cord-023095-4dannjjm 2719 11 used use VBN cord-023095-4dannjjm 2719 12 . . . cord-023095-4dannjjm 2720 1 Data datum NNS cord-023095-4dannjjm 2720 2 were be VBD cord-023095-4dannjjm 2720 3 analyzed analyze VBN cord-023095-4dannjjm 2720 4 using use VBG cord-023095-4dannjjm 2720 5 non non JJ cord-023095-4dannjjm 2720 6 - - JJ cord-023095-4dannjjm 2720 7 parametric parametric JJ cord-023095-4dannjjm 2720 8 tests test NNS cord-023095-4dannjjm 2720 9 . . . cord-023095-4dannjjm 2721 1 Reference reference NN cord-023095-4dannjjm 2721 2 ranges range VBZ cord-023095-4dannjjm 2721 3 for for IN cord-023095-4dannjjm 2721 4 cobalamin cobalamin NN cord-023095-4dannjjm 2721 5 , , , cord-023095-4dannjjm 2721 6 Hcy Hcy NNP cord-023095-4dannjjm 2721 7 , , , cord-023095-4dannjjm 2721 8 and and CC cord-023095-4dannjjm 2721 9 MMA MMA NNP cord-023095-4dannjjm 2721 10 were be VBD cord-023095-4dannjjm 2721 11 : : : cord-023095-4dannjjm 2721 12 cobalamin cobalamin VB cord-023095-4dannjjm 2721 13 279.2 279.2 CD cord-023095-4dannjjm 2721 14 - - HYPH cord-023095-4dannjjm 2721 15 972.8 972.8 CD cord-023095-4dannjjm 2721 16 ng ng NN cord-023095-4dannjjm 2721 17 / / SYM cord-023095-4dannjjm 2721 18 L l NN cord-023095-4dannjjm 2721 19 ; ; : cord-023095-4dannjjm 2722 1 urine urine NNP cord-023095-4dannjjm 2722 2 MMA MMA NNP cord-023095-4dannjjm 2722 3 2 2 CD cord-023095-4dannjjm 2722 4 - - SYM cord-023095-4dannjjm 2722 5 4.65 4.65 CD cord-023095-4dannjjm 2722 6 mmol mmol JJ cord-023095-4dannjjm 2722 7 / / SYM cord-023095-4dannjjm 2722 8 mol mol NN cord-023095-4dannjjm 2722 9 creatinine creatinine NN cord-023095-4dannjjm 2722 10 ; ; : cord-023095-4dannjjm 2722 11 and and CC cord-023095-4dannjjm 2722 12 plasma plasma NN cord-023095-4dannjjm 2722 13 Hcy Hcy NNP cord-023095-4dannjjm 2722 14 4.73 4.73 CD cord-023095-4dannjjm 2722 15 - - HYPH cord-023095-4dannjjm 2722 16 18.34 18.34 CD cord-023095-4dannjjm 2722 17 mmol mmol NNP cord-023095-4dannjjm 2722 18 / / SYM cord-023095-4dannjjm 2722 19 L. L. NNP cord-023095-4dannjjm 2723 1 The the DT cord-023095-4dannjjm 2723 2 screened screen VBN cord-023095-4dannjjm 2723 3 BC BC NNP cord-023095-4dannjjm 2723 4 population population NN cord-023095-4dannjjm 2723 5 comprised comprise VBD cord-023095-4dannjjm 2723 6 113 113 CD cord-023095-4dannjjm 2723 7 purebred purebred JJ cord-023095-4dannjjm 2723 8 dogs dog NNS cord-023095-4dannjjm 2723 9 and and CC cord-023095-4dannjjm 2723 10 4 4 CD cord-023095-4dannjjm 2723 11 BC BC NNP cord-023095-4dannjjm 2723 12 ( ( -LRB- cord-023095-4dannjjm 2723 13 median median JJ cord-023095-4dannjjm 2723 14 11.5 11.5 CD cord-023095-4dannjjm 2723 15 months month NNS cord-023095-4dannjjm 2723 16 ; ; : cord-023095-4dannjjm 2724 1 range range NNP cord-023095-4dannjjm 2724 2 8 8 CD cord-023095-4dannjjm 2724 3 - - SYM cord-023095-4dannjjm 2724 4 41 41 CD cord-023095-4dannjjm 2724 5 ) ) -RRB- cord-023095-4dannjjm 2724 6 suffering suffer VBG cord-023095-4dannjjm 2724 7 from from IN cord-023095-4dannjjm 2724 8 congenital congenital JJ cord-023095-4dannjjm 2724 9 CD cd NN cord-023095-4dannjjm 2724 10 could could MD cord-023095-4dannjjm 2724 11 be be VB cord-023095-4dannjjm 2724 12 identified identify VBN cord-023095-4dannjjm 2724 13 . . . cord-023095-4dannjjm 2725 1 Clinical clinical JJ cord-023095-4dannjjm 2725 2 signs sign NNS cord-023095-4dannjjm 2725 3 differed differ VBD cord-023095-4dannjjm 2725 4 and and CC cord-023095-4dannjjm 2725 5 consisted consist VBD cord-023095-4dannjjm 2725 6 of of IN cord-023095-4dannjjm 2725 7 tiredness tiredness NN cord-023095-4dannjjm 2725 8 ( ( -LRB- cord-023095-4dannjjm 2725 9 4 4 CD cord-023095-4dannjjm 2725 10 ) ) -RRB- cord-023095-4dannjjm 2725 11 , , , cord-023095-4dannjjm 2725 12 stunted stunted JJ cord-023095-4dannjjm 2725 13 growth growth NN cord-023095-4dannjjm 2725 14 ( ( -LRB- cord-023095-4dannjjm 2725 15 4 4 CD cord-023095-4dannjjm 2725 16 ) ) -RRB- cord-023095-4dannjjm 2725 17 , , , cord-023095-4dannjjm 2725 18 anemia anemia NN cord-023095-4dannjjm 2725 19 ( ( -LRB- cord-023095-4dannjjm 2725 20 3 3 CD cord-023095-4dannjjm 2725 21 ) ) -RRB- cord-023095-4dannjjm 2725 22 , , , cord-023095-4dannjjm 2725 23 dysphagia dysphagia NNP cord-023095-4dannjjm 2725 24 ( ( -LRB- cord-023095-4dannjjm 2725 25 2 2 CD cord-023095-4dannjjm 2725 26 ) ) -RRB- cord-023095-4dannjjm 2725 27 and and CC cord-023095-4dannjjm 2725 28 persistent persistent JJ cord-023095-4dannjjm 2725 29 fever fever NN cord-023095-4dannjjm 2725 30 ( ( -LRB- cord-023095-4dannjjm 2725 31 1 1 CD cord-023095-4dannjjm 2725 32 ) ) -RRB- cord-023095-4dannjjm 2725 33 . . . cord-023095-4dannjjm 2726 1 Median median JJ cord-023095-4dannjjm 2726 2 ( ( -LRB- cord-023095-4dannjjm 2726 3 ranges range NNS cord-023095-4dannjjm 2726 4 ) ) -RRB- cord-023095-4dannjjm 2726 5 results result NNS cord-023095-4dannjjm 2726 6 for for IN cord-023095-4dannjjm 2726 7 healthy healthy JJ cord-023095-4dannjjm 2726 8 BC BC NNP cord-023095-4dannjjm 2726 9 and and CC cord-023095-4dannjjm 2726 10 BC BC NNP cord-023095-4dannjjm 2726 11 with with IN cord-023095-4dannjjm 2726 12 CD CD NNP cord-023095-4dannjjm 2726 13 were be VBD cord-023095-4dannjjm 2726 14 : : : cord-023095-4dannjjm 2726 15 for for IN cord-023095-4dannjjm 2726 16 cobalamin cobalamin NN cord-023095-4dannjjm 2726 17 592 592 CD cord-023095-4dannjjm 2726 18 ( ( -LRB- cord-023095-4dannjjm 2726 19 142 142 CD cord-023095-4dannjjm 2726 20 - - SYM cord-023095-4dannjjm 2726 21 1855 1855 CD cord-023095-4dannjjm 2726 22 ) ) -RRB- cord-023095-4dannjjm 2726 23 and and CC cord-023095-4dannjjm 2726 24 72.00 72.00 CD cord-023095-4dannjjm 2726 25 ( ( -LRB- cord-023095-4dannjjm 2726 26 30 30 CD cord-023095-4dannjjm 2726 27 - - SYM cord-023095-4dannjjm 2726 28 139 139 CD cord-023095-4dannjjm 2726 29 ) ) -RRB- cord-023095-4dannjjm 2727 1 ng ng NNP cord-023095-4dannjjm 2727 2 / / SYM cord-023095-4dannjjm 2727 3 L L NNP cord-023095-4dannjjm 2727 4 ; ; : cord-023095-4dannjjm 2727 5 for for IN cord-023095-4dannjjm 2727 6 urine urine NN cord-023095-4dannjjm 2727 7 MMA MMA NNP cord-023095-4dannjjm 2727 8 2 2 CD cord-023095-4dannjjm 2727 9 ( ( -LRB- cord-023095-4dannjjm 2727 10 2 2 CD cord-023095-4dannjjm 2727 11 - - SYM cord-023095-4dannjjm 2727 12 360 360 CD cord-023095-4dannjjm 2727 13 ) ) -RRB- cord-023095-4dannjjm 2727 14 and and CC cord-023095-4dannjjm 2727 15 4148 4148 CD cord-023095-4dannjjm 2727 16 ( ( -LRB- cord-023095-4dannjjm 2727 17 1800 1800 CD cord-023095-4dannjjm 2727 18 - - SYM cord-023095-4dannjjm 2727 19 6665 6665 CD cord-023095-4dannjjm 2727 20 ) ) -RRB- cord-023095-4dannjjm 2728 1 mmol mmol NNP cord-023095-4dannjjm 2728 2 / / SYM cord-023095-4dannjjm 2728 3 mol mol NN cord-023095-4dannjjm 2728 4 creatinine creatinine NN cord-023095-4dannjjm 2728 5 ; ; : cord-023095-4dannjjm 2728 6 for for IN cord-023095-4dannjjm 2728 7 Hcy Hcy NNP cord-023095-4dannjjm 2728 8 8.5 8.5 CD cord-023095-4dannjjm 2728 9 ( ( -LRB- cord-023095-4dannjjm 2728 10 2.8 2.8 CD cord-023095-4dannjjm 2728 11 - - SYM cord-023095-4dannjjm 2728 12 22.4 22.4 CD cord-023095-4dannjjm 2728 13 ) ) -RRB- cord-023095-4dannjjm 2728 14 and and CC cord-023095-4dannjjm 2728 15 41.00 41.00 CD cord-023095-4dannjjm 2728 16 ( ( -LRB- cord-023095-4dannjjm 2728 17 40 40 CD cord-023095-4dannjjm 2728 18 - - SYM cord-023095-4dannjjm 2728 19 86.6 86.6 CD cord-023095-4dannjjm 2728 20 ) ) -RRB- cord-023095-4dannjjm 2728 21 mmol/ mmol/ . cord-023095-4dannjjm 2729 1 L. L. NNP cord-023095-4dannjjm 2729 2 Strikingly strikingly RB cord-023095-4dannjjm 2729 3 , , , cord-023095-4dannjjm 2729 4 healthy healthy JJ cord-023095-4dannjjm 2729 5 BC BC NNP cord-023095-4dannjjm 2729 6 with with IN cord-023095-4dannjjm 2729 7 cobalamin cobalamin NN cord-023095-4dannjjm 2729 8 concentrations concentration NNS cord-023095-4dannjjm 2729 9 well well RB cord-023095-4dannjjm 2729 10 within within IN cord-023095-4dannjjm 2729 11 the the DT cord-023095-4dannjjm 2729 12 reference reference NN cord-023095-4dannjjm 2729 13 range range NN cord-023095-4dannjjm 2729 14 had have VBD cord-023095-4dannjjm 2729 15 significantly significantly RB cord-023095-4dannjjm 2729 16 higher high JJR cord-023095-4dannjjm 2729 17 urine urine NN cord-023095-4dannjjm 2729 18 MMA MMA NNP cord-023095-4dannjjm 2729 19 concentrations concentration NNS cord-023095-4dannjjm 2729 20 compared compare VBN cord-023095-4dannjjm 2729 21 to to TO cord-023095-4dannjjm 2729 22 control control VB cord-023095-4dannjjm 2729 23 dogs dog NNS cord-023095-4dannjjm 2729 24 . . . cord-023095-4dannjjm 2730 1 Under under IN cord-023095-4dannjjm 2730 2 the the DT cord-023095-4dannjjm 2730 3 assumption assumption NN cord-023095-4dannjjm 2730 4 that that IN cord-023095-4dannjjm 2730 5 the the DT cord-023095-4dannjjm 2730 6 four four CD cord-023095-4dannjjm 2730 7 affected affect VBN cord-023095-4dannjjm 2730 8 BC BC NNP cord-023095-4dannjjm 2730 9 are be VBP cord-023095-4dannjjm 2730 10 inbred inbred JJ cord-023095-4dannjjm 2730 11 to to IN cord-023095-4dannjjm 2730 12 a a DT cord-023095-4dannjjm 2730 13 single single JJ cord-023095-4dannjjm 2730 14 founder founder NN cord-023095-4dannjjm 2730 15 animal animal NN cord-023095-4dannjjm 2730 16 , , , cord-023095-4dannjjm 2730 17 first first JJ cord-023095-4dannjjm 2730 18 results result NNS cord-023095-4dannjjm 2730 19 of of IN cord-023095-4dannjjm 2730 20 genotyping genotype VBG cord-023095-4dannjjm 2730 21 on on IN cord-023095-4dannjjm 2730 22 the the DT cord-023095-4dannjjm 2730 23 170 170 CD cord-023095-4dannjjm 2730 24 k k NNP cord-023095-4dannjjm 2730 25 illumina illumina NNP cord-023095-4dannjjm 2730 26 canine_HD canine_hd FW cord-023095-4dannjjm 2730 27 SNP SNP NNP cord-023095-4dannjjm 2730 28 chip chip NN cord-023095-4dannjjm 2730 29 suggest suggest VBP cord-023095-4dannjjm 2730 30 that that IN cord-023095-4dannjjm 2730 31 mutations mutation NNS cord-023095-4dannjjm 2730 32 in in IN cord-023095-4dannjjm 2730 33 the the DT cord-023095-4dannjjm 2730 34 CUBN CUBN NNP cord-023095-4dannjjm 2730 35 and and CC cord-023095-4dannjjm 2730 36 AMN AMN NNP cord-023095-4dannjjm 2730 37 gene gene NN cord-023095-4dannjjm 2730 38 can can MD cord-023095-4dannjjm 2730 39 be be VB cord-023095-4dannjjm 2730 40 excluded exclude VBN cord-023095-4dannjjm 2730 41 to to TO cord-023095-4dannjjm 2730 42 cause cause VB cord-023095-4dannjjm 2730 43 the the DT cord-023095-4dannjjm 2730 44 observed observed JJ cord-023095-4dannjjm 2730 45 CD cd NN cord-023095-4dannjjm 2730 46 in in IN cord-023095-4dannjjm 2730 47 these these DT cord-023095-4dannjjm 2730 48 dogs dog NNS cord-023095-4dannjjm 2730 49 . . . cord-023095-4dannjjm 2731 1 We -PRON- PRP cord-023095-4dannjjm 2731 2 conclude conclude VBP cord-023095-4dannjjm 2731 3 that that IN cord-023095-4dannjjm 2731 4 CD CD NNP cord-023095-4dannjjm 2731 5 is be VBZ cord-023095-4dannjjm 2731 6 a a DT cord-023095-4dannjjm 2731 7 rare rare JJ cord-023095-4dannjjm 2731 8 familial familial JJ cord-023095-4dannjjm 2731 9 disease disease NN cord-023095-4dannjjm 2731 10 in in IN cord-023095-4dannjjm 2731 11 BC BC NNP cord-023095-4dannjjm 2731 12 with with IN cord-023095-4dannjjm 2731 13 variable variable JJ cord-023095-4dannjjm 2731 14 clinical clinical JJ cord-023095-4dannjjm 2731 15 signs sign NNS cord-023095-4dannjjm 2731 16 . . . cord-023095-4dannjjm 2732 1 To to TO cord-023095-4dannjjm 2732 2 define define VB cord-023095-4dannjjm 2732 3 the the DT cord-023095-4dannjjm 2732 4 genomic genomic JJ cord-023095-4dannjjm 2732 5 region region NN cord-023095-4dannjjm 2732 6 responsible responsible JJ cord-023095-4dannjjm 2732 7 for for IN cord-023095-4dannjjm 2732 8 CD CD NNP cord-023095-4dannjjm 2732 9 further further JJ cord-023095-4dannjjm 2732 10 genetic genetic JJ cord-023095-4dannjjm 2732 11 analysis analysis NN cord-023095-4dannjjm 2732 12 is be VBZ cord-023095-4dannjjm 2732 13 in in IN cord-023095-4dannjjm 2732 14 progress progress NN cord-023095-4dannjjm 2732 15 . . . cord-023095-4dannjjm 2733 1 It -PRON- PRP cord-023095-4dannjjm 2733 2 remains remain VBZ cord-023095-4dannjjm 2733 3 to to TO cord-023095-4dannjjm 2733 4 be be VB cord-023095-4dannjjm 2733 5 determined determine VBN cord-023095-4dannjjm 2733 6 why why WRB cord-023095-4dannjjm 2733 7 some some DT cord-023095-4dannjjm 2733 8 BC BC NNP cord-023095-4dannjjm 2733 9 have have VBP cord-023095-4dannjjm 2733 10 high high JJ cord-023095-4dannjjm 2733 11 urine urine NN cord-023095-4dannjjm 2733 12 MMA MMA NNP cord-023095-4dannjjm 2733 13 concentrations concentration NNS cord-023095-4dannjjm 2733 14 despite despite IN cord-023095-4dannjjm 2733 15 a a DT cord-023095-4dannjjm 2733 16 serum serum NN cord-023095-4dannjjm 2733 17 cobalamin cobalamin NN cord-023095-4dannjjm 2733 18 concentration concentration NN cord-023095-4dannjjm 2733 19 within within IN cord-023095-4dannjjm 2733 20 the the DT cord-023095-4dannjjm 2733 21 reference reference NN cord-023095-4dannjjm 2733 22 range range NN cord-023095-4dannjjm 2733 23 . . . cord-023095-4dannjjm 2734 1 Calprotectin Calprotectin NNP cord-023095-4dannjjm 2734 2 is be VBZ cord-023095-4dannjjm 2734 3 a a DT cord-023095-4dannjjm 2734 4 protein protein NN cord-023095-4dannjjm 2734 5 complex complex NN cord-023095-4dannjjm 2734 6 that that WDT cord-023095-4dannjjm 2734 7 plays play VBZ cord-023095-4dannjjm 2734 8 an an DT cord-023095-4dannjjm 2734 9 important important JJ cord-023095-4dannjjm 2734 10 role role NN cord-023095-4dannjjm 2734 11 in in IN cord-023095-4dannjjm 2734 12 the the DT cord-023095-4dannjjm 2734 13 innate innate JJ cord-023095-4dannjjm 2734 14 immune immune JJ cord-023095-4dannjjm 2734 15 response response NN cord-023095-4dannjjm 2734 16 . . . cord-023095-4dannjjm 2735 1 Preliminary preliminary JJ cord-023095-4dannjjm 2735 2 data datum NNS cord-023095-4dannjjm 2735 3 suggest suggest VBP cord-023095-4dannjjm 2735 4 that that IN cord-023095-4dannjjm 2735 5 canine canine JJ cord-023095-4dannjjm 2735 6 calprotectin calprotectin NNS cord-023095-4dannjjm 2735 7 ( ( -LRB- cord-023095-4dannjjm 2735 8 cCP cCP NNP cord-023095-4dannjjm 2735 9 ) ) -RRB- cord-023095-4dannjjm 2735 10 is be VBZ cord-023095-4dannjjm 2735 11 a a DT cord-023095-4dannjjm 2735 12 useful useful JJ cord-023095-4dannjjm 2735 13 marker marker NN cord-023095-4dannjjm 2735 14 for for IN cord-023095-4dannjjm 2735 15 the the DT cord-023095-4dannjjm 2735 16 detection detection NN cord-023095-4dannjjm 2735 17 of of IN cord-023095-4dannjjm 2735 18 inflammation inflammation NN cord-023095-4dannjjm 2735 19 in in IN cord-023095-4dannjjm 2735 20 dogs dog NNS cord-023095-4dannjjm 2735 21 . . . cord-023095-4dannjjm 2736 1 Recently recently RB cord-023095-4dannjjm 2736 2 , , , cord-023095-4dannjjm 2736 3 a a DT cord-023095-4dannjjm 2736 4 radioimmunoassay radioimmunoassay NN cord-023095-4dannjjm 2736 5 for for IN cord-023095-4dannjjm 2736 6 the the DT cord-023095-4dannjjm 2736 7 measurement measurement NN cord-023095-4dannjjm 2736 8 of of IN cord-023095-4dannjjm 2736 9 cCP cCP NNP cord-023095-4dannjjm 2736 10 has have VBZ cord-023095-4dannjjm 2736 11 been be VBN cord-023095-4dannjjm 2736 12 developed develop VBN cord-023095-4dannjjm 2736 13 and and CC cord-023095-4dannjjm 2736 14 analytically analytically RB cord-023095-4dannjjm 2736 15 validated validate VBN cord-023095-4dannjjm 2736 16 , , , cord-023095-4dannjjm 2736 17 but but CC cord-023095-4dannjjm 2736 18 this this DT cord-023095-4dannjjm 2736 19 test test NN cord-023095-4dannjjm 2736 20 requires require VBZ cord-023095-4dannjjm 2736 21 the the DT cord-023095-4dannjjm 2736 22 use use NN cord-023095-4dannjjm 2736 23 of of IN cord-023095-4dannjjm 2736 24 a a DT cord-023095-4dannjjm 2736 25 radioactive radioactive JJ cord-023095-4dannjjm 2736 26 tracer tracer NN cord-023095-4dannjjm 2736 27 . . . cord-023095-4dannjjm 2737 1 Therefore therefore RB cord-023095-4dannjjm 2737 2 , , , cord-023095-4dannjjm 2737 3 the the DT cord-023095-4dannjjm 2737 4 aim aim NN cord-023095-4dannjjm 2737 5 of of IN cord-023095-4dannjjm 2737 6 this this DT cord-023095-4dannjjm 2737 7 study study NN cord-023095-4dannjjm 2737 8 was be VBD cord-023095-4dannjjm 2737 9 to to TO cord-023095-4dannjjm 2737 10 develop develop VB cord-023095-4dannjjm 2737 11 and and CC cord-023095-4dannjjm 2737 12 analytically analytically RB cord-023095-4dannjjm 2737 13 validate validate VB cord-023095-4dannjjm 2737 14 an an DT cord-023095-4dannjjm 2737 15 enzyme enzyme NN cord-023095-4dannjjm 2737 16 - - HYPH cord-023095-4dannjjm 2737 17 linked link VBN cord-023095-4dannjjm 2737 18 immunosorbent immunosorbent JJ cord-023095-4dannjjm 2737 19 assay assay NN cord-023095-4dannjjm 2737 20 ( ( -LRB- cord-023095-4dannjjm 2737 21 ELISA ELISA NNP cord-023095-4dannjjm 2737 22 ) ) -RRB- cord-023095-4dannjjm 2737 23 for for IN cord-023095-4dannjjm 2737 24 the the DT cord-023095-4dannjjm 2737 25 quantification quantification NN cord-023095-4dannjjm 2737 26 of of IN cord-023095-4dannjjm 2737 27 cCP cCP NNP cord-023095-4dannjjm 2737 28 in in IN cord-023095-4dannjjm 2737 29 serum serum NN cord-023095-4dannjjm 2737 30 and and CC cord-023095-4dannjjm 2737 31 fecal fecal JJ cord-023095-4dannjjm 2737 32 specimens specimen NNS cord-023095-4dannjjm 2737 33 from from IN cord-023095-4dannjjm 2737 34 dogs dog NNS cord-023095-4dannjjm 2737 35 . . . cord-023095-4dannjjm 2738 1 Canine canine JJ cord-023095-4dannjjm 2738 2 calprotectin calprotectin NNS cord-023095-4dannjjm 2738 3 ( ( -LRB- cord-023095-4dannjjm 2738 4 cCP ccp RB cord-023095-4dannjjm 2738 5 ) ) -RRB- cord-023095-4dannjjm 2738 6 was be VBD cord-023095-4dannjjm 2738 7 purified purify VBN cord-023095-4dannjjm 2738 8 , , , cord-023095-4dannjjm 2738 9 antiserum antiserum NN cord-023095-4dannjjm 2738 10 against against IN cord-023095-4dannjjm 2738 11 purified purify VBN cord-023095-4dannjjm 2738 12 cCP cCP NNP cord-023095-4dannjjm 2738 13 was be VBD cord-023095-4dannjjm 2738 14 raised raise VBN cord-023095-4dannjjm 2738 15 in in IN cord-023095-4dannjjm 2738 16 rabbits rabbit NNS cord-023095-4dannjjm 2738 17 , , , cord-023095-4dannjjm 2738 18 monospecific monospecific JJ cord-023095-4dannjjm 2738 19 antibodies antibody NNS cord-023095-4dannjjm 2738 20 were be VBD cord-023095-4dannjjm 2738 21 purified purify VBN cord-023095-4dannjjm 2738 22 by by IN cord-023095-4dannjjm 2738 23 affinity affinity NN cord-023095-4dannjjm 2738 24 chromatography chromatography NN cord-023095-4dannjjm 2738 25 , , , cord-023095-4dannjjm 2738 26 and and CC cord-023095-4dannjjm 2738 27 a a DT cord-023095-4dannjjm 2738 28 sandwich sandwich NN cord-023095-4dannjjm 2738 29 - - : cord-023095-4dannjjm 2738 30 ELISA ELISA NNP cord-023095-4dannjjm 2738 31 was be VBD cord-023095-4dannjjm 2738 32 developed develop VBN cord-023095-4dannjjm 2738 33 . . . cord-023095-4dannjjm 2739 1 Purified purify VBN cord-023095-4dannjjm 2739 2 antibodies antibody NNS cord-023095-4dannjjm 2739 3 were be VBD cord-023095-4dannjjm 2739 4 used use VBN cord-023095-4dannjjm 2739 5 for for IN cord-023095-4dannjjm 2739 6 capturing capture VBG cord-023095-4dannjjm 2739 7 and and CC cord-023095-4dannjjm 2739 8 , , , cord-023095-4dannjjm 2739 9 after after IN cord-023095-4dannjjm 2739 10 coupling couple VBG cord-023095-4dannjjm 2739 11 with with IN cord-023095-4dannjjm 2739 12 horseradish horseradish NN cord-023095-4dannjjm 2739 13 peroxidase peroxidase NN cord-023095-4dannjjm 2739 14 ( ( -LRB- cord-023095-4dannjjm 2739 15 HRP HRP NNP cord-023095-4dannjjm 2739 16 ) ) -RRB- cord-023095-4dannjjm 2739 17 , , , cord-023095-4dannjjm 2739 18 for for IN cord-023095-4dannjjm 2739 19 reporting report VBG cord-023095-4dannjjm 2739 20 . . . cord-023095-4dannjjm 2740 1 A a DT cord-023095-4dannjjm 2740 2 HRP HRP NNP cord-023095-4dannjjm 2740 3 substrate substrate NN cord-023095-4dannjjm 2740 4 was be VBD cord-023095-4dannjjm 2740 5 used use VBN cord-023095-4dannjjm 2740 6 for for IN cord-023095-4dannjjm 2740 7 color color NN cord-023095-4dannjjm 2740 8 development development NN cord-023095-4dannjjm 2740 9 . . . cord-023095-4dannjjm 2741 1 The the DT cord-023095-4dannjjm 2741 2 assay assay NN cord-023095-4dannjjm 2741 3 was be VBD cord-023095-4dannjjm 2741 4 analytically analytically RB cord-023095-4dannjjm 2741 5 validated validate VBN cord-023095-4dannjjm 2741 6 by by IN cord-023095-4dannjjm 2741 7 determination determination NN cord-023095-4dannjjm 2741 8 of of IN cord-023095-4dannjjm 2741 9 analytical analytical JJ cord-023095-4dannjjm 2741 10 sensitivity sensitivity NN cord-023095-4dannjjm 2741 11 and and CC cord-023095-4dannjjm 2741 12 specificity specificity NN cord-023095-4dannjjm 2741 13 , , , cord-023095-4dannjjm 2741 14 dilutional dilutional JJ cord-023095-4dannjjm 2741 15 parallelism parallelism NN cord-023095-4dannjjm 2741 16 , , , cord-023095-4dannjjm 2741 17 spiking spike VBG cord-023095-4dannjjm 2741 18 recovery recovery NN cord-023095-4dannjjm 2741 19 , , , cord-023095-4dannjjm 2741 20 and and CC cord-023095-4dannjjm 2741 21 intra intra JJ cord-023095-4dannjjm 2741 22 - - : cord-023095-4dannjjm 2741 23 and and CC cord-023095-4dannjjm 2741 24 inter inter JJ cord-023095-4dannjjm 2741 25 - - JJ cord-023095-4dannjjm 2741 26 assay assay JJ cord-023095-4dannjjm 2741 27 variability variability NN cord-023095-4dannjjm 2741 28 . . . cord-023095-4dannjjm 2742 1 Control control NN cord-023095-4dannjjm 2742 2 intervals interval NNS cord-023095-4dannjjm 2742 3 for for IN cord-023095-4dannjjm 2742 4 serum serum NN cord-023095-4dannjjm 2742 5 and and CC cord-023095-4dannjjm 2742 6 fecal fecal NN cord-023095-4dannjjm 2742 7 cCP cCP NNS cord-023095-4dannjjm 2742 8 were be VBD cord-023095-4dannjjm 2742 9 established establish VBN cord-023095-4dannjjm 2742 10 from from IN cord-023095-4dannjjm 2742 11 110 110 CD cord-023095-4dannjjm 2742 12 and and CC cord-023095-4dannjjm 2742 13 52 52 CD cord-023095-4dannjjm 2742 14 healthy healthy JJ cord-023095-4dannjjm 2742 15 pet pet JJ cord-023095-4dannjjm 2742 16 dogs dog NNS cord-023095-4dannjjm 2742 17 , , , cord-023095-4dannjjm 2742 18 respectively respectively RB cord-023095-4dannjjm 2742 19 , , , cord-023095-4dannjjm 2742 20 using use VBG cord-023095-4dannjjm 2742 21 the the DT cord-023095-4dannjjm 2742 22 central central JJ cord-023095-4dannjjm 2742 23 95 95 CD cord-023095-4dannjjm 2742 24 th th XX cord-023095-4dannjjm 2742 25 percentile percentile NN cord-023095-4dannjjm 2742 26 . . . cord-023095-4dannjjm 2743 1 Sensitivity sensitivity NN cord-023095-4dannjjm 2743 2 of of IN cord-023095-4dannjjm 2743 3 the the DT cord-023095-4dannjjm 2743 4 assay assay NN cord-023095-4dannjjm 2743 5 for for IN cord-023095-4dannjjm 2743 6 serum serum NN cord-023095-4dannjjm 2743 7 samples sample NNS cord-023095-4dannjjm 2743 8 assayed assay VBN cord-023095-4dannjjm 2743 9 in in IN cord-023095-4dannjjm 2743 10 a a DT cord-023095-4dannjjm 2743 11 1:400 1:400 CD cord-023095-4dannjjm 2743 12 dilution dilution NN cord-023095-4dannjjm 2743 13 and and CC cord-023095-4dannjjm 2743 14 for for IN cord-023095-4dannjjm 2743 15 fecal fecal JJ cord-023095-4dannjjm 2743 16 extracts extract NNS cord-023095-4dannjjm 2743 17 assayed assay VBN cord-023095-4dannjjm 2743 18 in in IN cord-023095-4dannjjm 2743 19 a a DT cord-023095-4dannjjm 2743 20 1:4,000 1:4,000 CD cord-023095-4dannjjm 2743 21 dilution dilution NN cord-023095-4dannjjm 2743 22 was be VBD cord-023095-4dannjjm 2743 23 0.3 0.3 CD cord-023095-4dannjjm 2743 24 mg mg NNP cord-023095-4dannjjm 2743 25 / / SYM cord-023095-4dannjjm 2743 26 L L NNP cord-023095-4dannjjm 2743 27 and and CC cord-023095-4dannjjm 2743 28 3.2 3.2 CD cord-023095-4dannjjm 2743 29 mg mg NNP cord-023095-4dannjjm 2743 30 / / SYM cord-023095-4dannjjm 2743 31 g g NNP cord-023095-4dannjjm 2743 32 , , , cord-023095-4dannjjm 2743 33 respectively respectively RB cord-023095-4dannjjm 2743 34 . . . cord-023095-4dannjjm 2744 1 Over over IN cord-023095-4dannjjm 2744 2 a a DT cord-023095-4dannjjm 2744 3 wide wide JJ cord-023095-4dannjjm 2744 4 range range NN cord-023095-4dannjjm 2744 5 of of IN cord-023095-4dannjjm 2744 6 the the DT cord-023095-4dannjjm 2744 7 assay assay NN cord-023095-4dannjjm 2744 8 , , , cord-023095-4dannjjm 2744 9 there there EX cord-023095-4dannjjm 2744 10 was be VBD cord-023095-4dannjjm 2744 11 no no DT cord-023095-4dannjjm 2744 12 cross cross NN cord-023095-4dannjjm 2744 13 - - NN cord-023095-4dannjjm 2744 14 reactivity reactivity NN cord-023095-4dannjjm 2744 15 with with IN cord-023095-4dannjjm 2744 16 cS100A12 cs100a12 NN cord-023095-4dannjjm 2744 17 , , , cord-023095-4dannjjm 2744 18 the the DT cord-023095-4dannjjm 2744 19 closest close JJS cord-023095-4dannjjm 2744 20 structural structural JJ cord-023095-4dannjjm 2744 21 analogue analogue NN cord-023095-4dannjjm 2744 22 of of IN cord-023095-4dannjjm 2744 23 cCP ccp RB cord-023095-4dannjjm 2744 24 available available JJ cord-023095-4dannjjm 2744 25 . . . cord-023095-4dannjjm 2745 1 Observed observe VBN cord-023095-4dannjjm 2745 2 to to TO cord-023095-4dannjjm 2745 3 expected expect VBN cord-023095-4dannjjm 2745 4 ratios ratio NNS cord-023095-4dannjjm 2745 5 ( ( -LRB- cord-023095-4dannjjm 2745 6 O o UH cord-023095-4dannjjm 2745 7 / / SYM cord-023095-4dannjjm 2745 8 E e NN cord-023095-4dannjjm 2745 9 ) ) -RRB- cord-023095-4dannjjm 2745 10 for for IN cord-023095-4dannjjm 2745 11 serial serial JJ cord-023095-4dannjjm 2745 12 dilutions dilution NNS cord-023095-4dannjjm 2745 13 ranged range VBD cord-023095-4dannjjm 2745 14 from from IN cord-023095-4dannjjm 2745 15 83.2 83.2 CD cord-023095-4dannjjm 2745 16 - - HYPH cord-023095-4dannjjm 2745 17 118.5 118.5 CD cord-023095-4dannjjm 2745 18 % % NN cord-023095-4dannjjm 2745 19 ( ( -LRB- cord-023095-4dannjjm 2745 20 mean mean VB cord-023095-4dannjjm 2745 21 AE AE NNP cord-023095-4dannjjm 2745 22 standard standard JJ cord-023095-4dannjjm 2745 23 deviation deviation NN cord-023095-4dannjjm 2745 24 [ [ -LRB- cord-023095-4dannjjm 2745 25 SD sd NN cord-023095-4dannjjm 2745 26 ] ] -RRB- cord-023095-4dannjjm 2745 27 : : : cord-023095-4dannjjm 2746 1 101.3 101.3 CD cord-023095-4dannjjm 2746 2 AE AE NNP cord-023095-4dannjjm 2746 3 10.0 10.0 CD cord-023095-4dannjjm 2746 4 % % NN cord-023095-4dannjjm 2746 5 ) ) -RRB- cord-023095-4dannjjm 2746 6 for for IN cord-023095-4dannjjm 2746 7 four four CD cord-023095-4dannjjm 2746 8 different different JJ cord-023095-4dannjjm 2746 9 serum serum NN cord-023095-4dannjjm 2746 10 samples sample NNS cord-023095-4dannjjm 2746 11 , , , cord-023095-4dannjjm 2746 12 and and CC cord-023095-4dannjjm 2746 13 from from IN cord-023095-4dannjjm 2746 14 81.7 81.7 CD cord-023095-4dannjjm 2746 15 - - HYPH cord-023095-4dannjjm 2746 16 129.1 129.1 CD cord-023095-4dannjjm 2746 17 % % NN cord-023095-4dannjjm 2746 18 ( ( -LRB- cord-023095-4dannjjm 2746 19 mean mean VB cord-023095-4dannjjm 2746 20 AE AE NNP cord-023095-4dannjjm 2746 21 SD SD NNP cord-023095-4dannjjm 2746 22 : : : cord-023095-4dannjjm 2746 23 101.8 101.8 CD cord-023095-4dannjjm 2746 24 AE AE NNP cord-023095-4dannjjm 2746 25 14.0 14.0 CD cord-023095-4dannjjm 2746 26 % % NN cord-023095-4dannjjm 2746 27 ) ) -RRB- cord-023095-4dannjjm 2746 28 for for IN cord-023095-4dannjjm 2746 29 five five CD cord-023095-4dannjjm 2746 30 different different JJ cord-023095-4dannjjm 2746 31 fecal fecal JJ cord-023095-4dannjjm 2746 32 extracts extract NNS cord-023095-4dannjjm 2746 33 . . . cord-023095-4dannjjm 2747 1 O o UH cord-023095-4dannjjm 2747 2 / / SYM cord-023095-4dannjjm 2747 3 E e NN cord-023095-4dannjjm 2747 4 for for IN cord-023095-4dannjjm 2747 5 spiking spike VBG cord-023095-4dannjjm 2747 6 recovery recovery NN cord-023095-4dannjjm 2747 7 ranged range VBD cord-023095-4dannjjm 2747 8 from from IN cord-023095-4dannjjm 2747 9 87.8 87.8 CD cord-023095-4dannjjm 2747 10 - - HYPH cord-023095-4dannjjm 2747 11 130.4 130.4 CD cord-023095-4dannjjm 2747 12 % % NN cord-023095-4dannjjm 2747 13 ( ( -LRB- cord-023095-4dannjjm 2747 14 mean mean VB cord-023095-4dannjjm 2747 15 AE AE NNP cord-023095-4dannjjm 2747 16 SD SD NNP cord-023095-4dannjjm 2747 17 : : : cord-023095-4dannjjm 2747 18 100.6 100.6 CD cord-023095-4dannjjm 2747 19 AE AE NNP cord-023095-4dannjjm 2747 20 6.5 6.5 CD cord-023095-4dannjjm 2747 21 % % NN cord-023095-4dannjjm 2747 22 ) ) -RRB- cord-023095-4dannjjm 2747 23 for for IN cord-023095-4dannjjm 2747 24 four four CD cord-023095-4dannjjm 2747 25 different different JJ cord-023095-4dannjjm 2747 26 serum serum NN cord-023095-4dannjjm 2747 27 samples sample NNS cord-023095-4dannjjm 2747 28 and and CC cord-023095-4dannjjm 2747 29 6 6 CD cord-023095-4dannjjm 2747 30 different different JJ cord-023095-4dannjjm 2747 31 spiking spiking NN cord-023095-4dannjjm 2747 32 concentrations concentration NNS cord-023095-4dannjjm 2747 33 , , , cord-023095-4dannjjm 2747 34 and and CC cord-023095-4dannjjm 2747 35 from from IN cord-023095-4dannjjm 2747 36 95.9 95.9 CD cord-023095-4dannjjm 2747 37 - - SYM cord-023095-4dannjjm 2747 38 152.0 152.0 CD cord-023095-4dannjjm 2747 39 % % NN cord-023095-4dannjjm 2747 40 ( ( -LRB- cord-023095-4dannjjm 2747 41 mean mean VB cord-023095-4dannjjm 2747 42 AE AE NNP cord-023095-4dannjjm 2747 43 SD SD NNP cord-023095-4dannjjm 2747 44 : : : cord-023095-4dannjjm 2747 45 104.6 104.6 CD cord-023095-4dannjjm 2747 46 AE AE NNP cord-023095-4dannjjm 2747 47 11.6 11.6 CD cord-023095-4dannjjm 2747 48 % % NN cord-023095-4dannjjm 2747 49 ) ) -RRB- cord-023095-4dannjjm 2747 50 for for IN cord-023095-4dannjjm 2747 51 4 4 CD cord-023095-4dannjjm 2747 52 different different JJ cord-023095-4dannjjm 2747 53 fecal fecal JJ cord-023095-4dannjjm 2747 54 extracts extract NNS cord-023095-4dannjjm 2747 55 and and CC cord-023095-4dannjjm 2747 56 6 6 CD cord-023095-4dannjjm 2747 57 different different JJ cord-023095-4dannjjm 2747 58 spiking spiking NN cord-023095-4dannjjm 2747 59 concentrations concentration NNS cord-023095-4dannjjm 2747 60 . . . cord-023095-4dannjjm 2748 1 Intra intra JJ cord-023095-4dannjjm 2748 2 - - JJ cord-023095-4dannjjm 2748 3 assay assay NN cord-023095-4dannjjm 2748 4 coefficients coefficient NNS cord-023095-4dannjjm 2748 5 of of IN cord-023095-4dannjjm 2748 6 variation variation NN cord-023095-4dannjjm 2748 7 ( ( -LRB- cord-023095-4dannjjm 2748 8 CV CV NNP cord-023095-4dannjjm 2748 9 ) ) -RRB- cord-023095-4dannjjm 2748 10 for for IN cord-023095-4dannjjm 2748 11 4 4 CD cord-023095-4dannjjm 2748 12 different different JJ cord-023095-4dannjjm 2748 13 serum serum NN cord-023095-4dannjjm 2748 14 samples sample NNS cord-023095-4dannjjm 2748 15 were be VBD cord-023095-4dannjjm 2748 16 7.8 7.8 CD cord-023095-4dannjjm 2748 17 , , , cord-023095-4dannjjm 2748 18 5.0 5.0 CD cord-023095-4dannjjm 2748 19 , , , cord-023095-4dannjjm 2748 20 7.4 7.4 CD cord-023095-4dannjjm 2748 21 , , , cord-023095-4dannjjm 2748 22 and and CC cord-023095-4dannjjm 2748 23 12.7 12.7 CD cord-023095-4dannjjm 2748 24 % % NN cord-023095-4dannjjm 2748 25 , , , cord-023095-4dannjjm 2748 26 and and CC cord-023095-4dannjjm 2748 27 10.0 10.0 CD cord-023095-4dannjjm 2748 28 , , , cord-023095-4dannjjm 2748 29 6.1 6.1 CD cord-023095-4dannjjm 2748 30 , , , cord-023095-4dannjjm 2748 31 6.2 6.2 CD cord-023095-4dannjjm 2748 32 , , , cord-023095-4dannjjm 2748 33 and and CC cord-023095-4dannjjm 2748 34 7.0 7.0 CD cord-023095-4dannjjm 2748 35 % % NN cord-023095-4dannjjm 2748 36 for for IN cord-023095-4dannjjm 2748 37 4 4 CD cord-023095-4dannjjm 2748 38 different different JJ cord-023095-4dannjjm 2748 39 fecal fecal JJ cord-023095-4dannjjm 2748 40 extracts extract NNS cord-023095-4dannjjm 2748 41 . . . cord-023095-4dannjjm 2749 1 Inter Inter NNP cord-023095-4dannjjm 2749 2 - - NN cord-023095-4dannjjm 2749 3 assay assay NN cord-023095-4dannjjm 2749 4 CV cv NN cord-023095-4dannjjm 2749 5 for for IN cord-023095-4dannjjm 2749 6 4 4 CD cord-023095-4dannjjm 2749 7 different different JJ cord-023095-4dannjjm 2749 8 serum serum NN cord-023095-4dannjjm 2749 9 samples sample NNS cord-023095-4dannjjm 2749 10 were be VBD cord-023095-4dannjjm 2749 11 17 17 CD cord-023095-4dannjjm 2749 12 . . . cord-023095-4dannjjm 2750 1 2 2 LS cord-023095-4dannjjm 2750 2 , , , cord-023095-4dannjjm 2750 3 8.1 8.1 CD cord-023095-4dannjjm 2750 4 , , , cord-023095-4dannjjm 2750 5 9.9 9.9 CD cord-023095-4dannjjm 2750 6 , , , cord-023095-4dannjjm 2750 7 and and CC cord-023095-4dannjjm 2750 8 12.6 12.6 CD cord-023095-4dannjjm 2750 9 % % NN cord-023095-4dannjjm 2750 10 , , , cord-023095-4dannjjm 2750 11 and and CC cord-023095-4dannjjm 2750 12 12.3 12.3 CD cord-023095-4dannjjm 2750 13 , , , cord-023095-4dannjjm 2750 14 8.3 8.3 CD cord-023095-4dannjjm 2750 15 , , , cord-023095-4dannjjm 2750 16 7.2 7.2 CD cord-023095-4dannjjm 2750 17 , , , cord-023095-4dannjjm 2750 18 and and CC cord-023095-4dannjjm 2750 19 9 9 CD cord-023095-4dannjjm 2750 20 .6 .6 CD cord-023095-4dannjjm 2750 21 % % NN cord-023095-4dannjjm 2750 22 for for IN cord-023095-4dannjjm 2750 23 4 4 CD cord-023095-4dannjjm 2750 24 different different JJ cord-023095-4dannjjm 2750 25 fecal fecal JJ cord-023095-4dannjjm 2750 26 extracts extract NNS cord-023095-4dannjjm 2750 27 . . . cord-023095-4dannjjm 2751 1 The the DT cord-023095-4dannjjm 2751 2 control control NN cord-023095-4dannjjm 2751 3 intervals interval NNS cord-023095-4dannjjm 2751 4 for for IN cord-023095-4dannjjm 2751 5 serum serum NN cord-023095-4dannjjm 2751 6 and and CC cord-023095-4dannjjm 2751 7 fecal fecal NN cord-023095-4dannjjm 2751 8 cCP cCP NNS cord-023095-4dannjjm 2751 9 were be VBD cord-023095-4dannjjm 2751 10 established establish VBN cord-023095-4dannjjm 2751 11 as as IN cord-023095-4dannjjm 2751 12 0.9 0.9 CD cord-023095-4dannjjm 2751 13 - - SYM cord-023095-4dannjjm 2751 14 11.9 11.9 CD cord-023095-4dannjjm 2751 15 mg mg NNP cord-023095-4dannjjm 2751 16 / / SYM cord-023095-4dannjjm 2751 17 L L NNP cord-023095-4dannjjm 2751 18 and and CC cord-023095-4dannjjm 2751 19 3.2 3.2 CD cord-023095-4dannjjm 2751 20 - - HYPH cord-023095-4dannjjm 2751 21 65.4 65.4 CD cord-023095-4dannjjm 2751 22 mg mg NNP cord-023095-4dannjjm 2751 23 / / SYM cord-023095-4dannjjm 2751 24 g g NNP cord-023095-4dannjjm 2751 25 , , , cord-023095-4dannjjm 2751 26 respectively respectively RB cord-023095-4dannjjm 2751 27 . . . cord-023095-4dannjjm 2752 1 We -PRON- PRP cord-023095-4dannjjm 2752 2 conclude conclude VBP cord-023095-4dannjjm 2752 3 that that IN cord-023095-4dannjjm 2752 4 this this DT cord-023095-4dannjjm 2752 5 new new JJ cord-023095-4dannjjm 2752 6 ELISA ELISA NNP cord-023095-4dannjjm 2752 7 for for IN cord-023095-4dannjjm 2752 8 the the DT cord-023095-4dannjjm 2752 9 measurement measurement NN cord-023095-4dannjjm 2752 10 of of IN cord-023095-4dannjjm 2752 11 cCP cCP NNP cord-023095-4dannjjm 2752 12 is be VBZ cord-023095-4dannjjm 2752 13 analytically analytically RB cord-023095-4dannjjm 2752 14 sensitive sensitive JJ cord-023095-4dannjjm 2752 15 , , , cord-023095-4dannjjm 2752 16 linear linear JJ cord-023095-4dannjjm 2752 17 , , , cord-023095-4dannjjm 2752 18 accurate accurate JJ cord-023095-4dannjjm 2752 19 , , , cord-023095-4dannjjm 2752 20 precise precise JJ cord-023095-4dannjjm 2752 21 , , , cord-023095-4dannjjm 2752 22 and and CC cord-023095-4dannjjm 2752 23 reproducible reproducible JJ cord-023095-4dannjjm 2752 24 , , , cord-023095-4dannjjm 2752 25 and and CC cord-023095-4dannjjm 2752 26 does do VBZ cord-023095-4dannjjm 2752 27 not not RB cord-023095-4dannjjm 2752 28 cross cross VB cord-023095-4dannjjm 2752 29 - - JJ cord-023095-4dannjjm 2752 30 react react VB cord-023095-4dannjjm 2752 31 with with IN cord-023095-4dannjjm 2752 32 canine canine JJ cord-023095-4dannjjm 2752 33 S100A12 s100a12 NN cord-023095-4dannjjm 2752 34 . . . cord-023095-4dannjjm 2753 1 Further further JJ cord-023095-4dannjjm 2753 2 studies study NNS cord-023095-4dannjjm 2753 3 evaluating evaluate VBG cord-023095-4dannjjm 2753 4 the the DT cord-023095-4dannjjm 2753 5 clinical clinical JJ cord-023095-4dannjjm 2753 6 usefulness usefulness NN cord-023095-4dannjjm 2753 7 of of IN cord-023095-4dannjjm 2753 8 measuring measure VBG cord-023095-4dannjjm 2753 9 serum serum NN cord-023095-4dannjjm 2754 1 and/or and/or CC cord-023095-4dannjjm 2754 2 fecal fecal JJ cord-023095-4dannjjm 2755 1 cCP ccp RB cord-023095-4dannjjm 2755 2 are be VBP cord-023095-4dannjjm 2755 3 currently currently RB cord-023095-4dannjjm 2755 4 under under IN cord-023095-4dannjjm 2755 5 way way NN cord-023095-4dannjjm 2755 6 . . . cord-023095-4dannjjm 2756 1 The the DT cord-023095-4dannjjm 2756 2 syndrome syndrome NN cord-023095-4dannjjm 2756 3 of of IN cord-023095-4dannjjm 2756 4 hemorrhagic hemorrhagic JJ cord-023095-4dannjjm 2756 5 gastroenteritis gastroenteritis NN cord-023095-4dannjjm 2756 6 ( ( -LRB- cord-023095-4dannjjm 2756 7 HGE HGE NNP cord-023095-4dannjjm 2756 8 ) ) -RRB- cord-023095-4dannjjm 2756 9 is be VBZ cord-023095-4dannjjm 2756 10 characterized characterize VBN cord-023095-4dannjjm 2756 11 by by IN cord-023095-4dannjjm 2756 12 a a DT cord-023095-4dannjjm 2756 13 peracute peracute JJ cord-023095-4dannjjm 2756 14 onset onset NN cord-023095-4dannjjm 2756 15 of of IN cord-023095-4dannjjm 2756 16 hemorrhagic hemorrhagic JJ cord-023095-4dannjjm 2756 17 diarrhea diarrhea NN cord-023095-4dannjjm 2756 18 , , , cord-023095-4dannjjm 2756 19 vomiting vomiting NN cord-023095-4dannjjm 2756 20 , , , cord-023095-4dannjjm 2756 21 depression depression NN cord-023095-4dannjjm 2756 22 , , , cord-023095-4dannjjm 2756 23 and and CC cord-023095-4dannjjm 2756 24 anorexia anorexia NN cord-023095-4dannjjm 2756 25 , , , cord-023095-4dannjjm 2756 26 and and CC cord-023095-4dannjjm 2756 27 can can MD cord-023095-4dannjjm 2756 28 be be VB cord-023095-4dannjjm 2756 29 associated associate VBN cord-023095-4dannjjm 2756 30 with with IN cord-023095-4dannjjm 2756 31 a a DT cord-023095-4dannjjm 2756 32 high high JJ cord-023095-4dannjjm 2756 33 mortality mortality NN cord-023095-4dannjjm 2756 34 if if IN cord-023095-4dannjjm 2756 35 untreated untreated JJ cord-023095-4dannjjm 2756 36 . . . cord-023095-4dannjjm 2757 1 The the DT cord-023095-4dannjjm 2757 2 etiology etiology NN cord-023095-4dannjjm 2757 3 of of IN cord-023095-4dannjjm 2757 4 HGE HGE NNP cord-023095-4dannjjm 2757 5 is be VBZ cord-023095-4dannjjm 2757 6 unknown unknown JJ cord-023095-4dannjjm 2757 7 , , , cord-023095-4dannjjm 2757 8 but but CC cord-023095-4dannjjm 2757 9 it -PRON- PRP cord-023095-4dannjjm 2757 10 is be VBZ cord-023095-4dannjjm 2757 11 speculated speculate VBN cord-023095-4dannjjm 2757 12 that that IN cord-023095-4dannjjm 2757 13 an an DT cord-023095-4dannjjm 2757 14 abnormal abnormal JJ cord-023095-4dannjjm 2757 15 response response NN cord-023095-4dannjjm 2757 16 to to IN cord-023095-4dannjjm 2757 17 bacterial bacterial JJ cord-023095-4dannjjm 2757 18 endotoxins endotoxin NNS cord-023095-4dannjjm 2757 19 , , , cord-023095-4dannjjm 2757 20 bacteria bacteria NNS cord-023095-4dannjjm 2757 21 , , , cord-023095-4dannjjm 2757 22 or or CC cord-023095-4dannjjm 2757 23 dietary dietary JJ cord-023095-4dannjjm 2757 24 components component NNS cord-023095-4dannjjm 2757 25 may may MD cord-023095-4dannjjm 2757 26 play play VB cord-023095-4dannjjm 2757 27 a a DT cord-023095-4dannjjm 2757 28 role role NN cord-023095-4dannjjm 2757 29 . . . cord-023095-4dannjjm 2758 1 HGE HGE NNP cord-023095-4dannjjm 2758 2 is be VBZ cord-023095-4dannjjm 2758 3 characterized characterize VBN cord-023095-4dannjjm 2758 4 by by IN cord-023095-4dannjjm 2758 5 an an DT cord-023095-4dannjjm 2758 6 increased increase VBN cord-023095-4dannjjm 2758 7 vascular vascular JJ cord-023095-4dannjjm 2758 8 / / HYPH cord-023095-4dannjjm 2758 9 mucosal mucosal JJ cord-023095-4dannjjm 2758 10 permeability permeability NN cord-023095-4dannjjm 2758 11 , , , cord-023095-4dannjjm 2758 12 thought think VBD cord-023095-4dannjjm 2758 13 to to TO cord-023095-4dannjjm 2758 14 represent represent VB cord-023095-4dannjjm 2758 15 a a DT cord-023095-4dannjjm 2758 16 type type NN cord-023095-4dannjjm 2758 17 I i NN cord-023095-4dannjjm 2758 18 - - HYPH cord-023095-4dannjjm 2758 19 hypersensitivity hypersensitivity NN cord-023095-4dannjjm 2758 20 reaction reaction NN cord-023095-4dannjjm 2758 21 , , , cord-023095-4dannjjm 2758 22 whereas whereas IN cord-023095-4dannjjm 2758 23 inflammation inflammation NN cord-023095-4dannjjm 2758 24 and and CC cord-023095-4dannjjm 2758 25 necrosis necrosis NN cord-023095-4dannjjm 2758 26 appear appear VBP cord-023095-4dannjjm 2758 27 to to TO cord-023095-4dannjjm 2758 28 be be VB cord-023095-4dannjjm 2758 29 rare rare JJ cord-023095-4dannjjm 2758 30 . . . cord-023095-4dannjjm 2759 1 However however RB cord-023095-4dannjjm 2759 2 , , , cord-023095-4dannjjm 2759 3 markers marker NNS cord-023095-4dannjjm 2759 4 of of IN cord-023095-4dannjjm 2759 5 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2759 6 ( ( -LRB- cord-023095-4dannjjm 2759 7 GI gi NN cord-023095-4dannjjm 2759 8 ) ) -RRB- cord-023095-4dannjjm 2759 9 inflammation inflammation NN cord-023095-4dannjjm 2759 10 and and CC cord-023095-4dannjjm 2759 11 changes change NNS cord-023095-4dannjjm 2759 12 in in IN cord-023095-4dannjjm 2759 13 the the DT cord-023095-4dannjjm 2759 14 intestinal intestinal JJ cord-023095-4dannjjm 2759 15 microbiota microbiota NN cord-023095-4dannjjm 2759 16 have have VBP cord-023095-4dannjjm 2759 17 not not RB cord-023095-4dannjjm 2759 18 been be VBN cord-023095-4dannjjm 2759 19 studied study VBN cord-023095-4dannjjm 2759 20 extensively extensively RB cord-023095-4dannjjm 2759 21 in in IN cord-023095-4dannjjm 2759 22 dogs dog NNS cord-023095-4dannjjm 2759 23 with with IN cord-023095-4dannjjm 2759 24 HGE HGE NNP cord-023095-4dannjjm 2759 25 . . . cord-023095-4dannjjm 2760 1 Therefore therefore RB cord-023095-4dannjjm 2760 2 , , , cord-023095-4dannjjm 2760 3 the the DT cord-023095-4dannjjm 2760 4 aim aim NN cord-023095-4dannjjm 2760 5 of of IN cord-023095-4dannjjm 2760 6 this this DT cord-023095-4dannjjm 2760 7 study study NN cord-023095-4dannjjm 2760 8 was be VBD cord-023095-4dannjjm 2760 9 to to TO cord-023095-4dannjjm 2760 10 evaluate evaluate VB cord-023095-4dannjjm 2760 11 fecal fecal JJ cord-023095-4dannjjm 2760 12 canine canine JJ cord-023095-4dannjjm 2760 13 calprotectin calprotectin NNS cord-023095-4dannjjm 2760 14 ( ( -LRB- cord-023095-4dannjjm 2760 15 CP CP NNP cord-023095-4dannjjm 2760 16 ) ) -RRB- cord-023095-4dannjjm 2760 17 and and CC cord-023095-4dannjjm 2760 18 S100A12 s100a12 JJ cord-023095-4dannjjm 2760 19 ( ( -LRB- cord-023095-4dannjjm 2760 20 A12 A12 NNP cord-023095-4dannjjm 2760 21 ) ) -RRB- cord-023095-4dannjjm 2760 22 , , , cord-023095-4dannjjm 2760 23 a a DT cord-023095-4dannjjm 2760 24 1 1 CD cord-023095-4dannjjm 2760 25 -proteinase -proteinase NN cord-023095-4dannjjm 2760 26 inhibitor inhibitor NN cord-023095-4dannjjm 2760 27 ( ( -LRB- cord-023095-4dannjjm 2760 28 a a DT cord-023095-4dannjjm 2760 29 1 1 CD cord-023095-4dannjjm 2760 30 -PI -pi NN cord-023095-4dannjjm 2760 31 , , , cord-023095-4dannjjm 2760 32 a a DT cord-023095-4dannjjm 2760 33 marker marker NN cord-023095-4dannjjm 2760 34 of of IN cord-023095-4dannjjm 2760 35 GI GI NNP cord-023095-4dannjjm 2760 36 protein protein NN cord-023095-4dannjjm 2760 37 loss loss NN cord-023095-4dannjjm 2760 38 ) ) -RRB- cord-023095-4dannjjm 2760 39 , , , cord-023095-4dannjjm 2760 40 and and CC cord-023095-4dannjjm 2760 41 bacterial bacterial JJ cord-023095-4dannjjm 2760 42 groups group NNS cord-023095-4dannjjm 2760 43 that that WDT cord-023095-4dannjjm 2760 44 have have VBP cord-023095-4dannjjm 2760 45 previously previously RB cord-023095-4dannjjm 2760 46 been be VBN cord-023095-4dannjjm 2760 47 shown show VBN cord-023095-4dannjjm 2760 48 to to TO cord-023095-4dannjjm 2760 49 be be VB cord-023095-4dannjjm 2760 50 decreased decrease VBN cord-023095-4dannjjm 2760 51 ( ( -LRB- cord-023095-4dannjjm 2760 52 i.e. i.e. FW cord-023095-4dannjjm 2760 53 , , , cord-023095-4dannjjm 2760 54 Faecalibacterium Faecalibacterium NNP cord-023095-4dannjjm 2760 55 spp spp NNS cord-023095-4dannjjm 2760 56 . . . cord-023095-4dannjjm 2761 1 , , , cord-023095-4dannjjm 2761 2 Ruminococcaceae Ruminococcaceae NNP cord-023095-4dannjjm 2761 3 , , , cord-023095-4dannjjm 2761 4 Bifidobacterium bifidobacterium NN cord-023095-4dannjjm 2761 5 spp spp NNS cord-023095-4dannjjm 2761 6 . . . cord-023095-4dannjjm 2761 7 ) ) -RRB- cord-023095-4dannjjm 2761 8 or or CC cord-023095-4dannjjm 2761 9 increased increase VBN cord-023095-4dannjjm 2761 10 ( ( -LRB- cord-023095-4dannjjm 2761 11 i.e. i.e. FW cord-023095-4dannjjm 2761 12 , , , cord-023095-4dannjjm 2761 13 Proteobacteria Proteobacteria NNP cord-023095-4dannjjm 2761 14 ) ) -RRB- cord-023095-4dannjjm 2761 15 in in IN cord-023095-4dannjjm 2761 16 fecal fecal JJ cord-023095-4dannjjm 2761 17 samples sample NNS cord-023095-4dannjjm 2761 18 from from IN cord-023095-4dannjjm 2761 19 dogs dog NNS cord-023095-4dannjjm 2761 20 with with IN cord-023095-4dannjjm 2761 21 HGE HGE NNP cord-023095-4dannjjm 2761 22 . . . cord-023095-4dannjjm 2762 1 Fecal fecal JJ cord-023095-4dannjjm 2762 2 samples sample NNS cord-023095-4dannjjm 2762 3 from from IN cord-023095-4dannjjm 2762 4 3 3 CD cord-023095-4dannjjm 2762 5 consecutive consecutive JJ cord-023095-4dannjjm 2762 6 days day NNS cord-023095-4dannjjm 2762 7 were be VBD cord-023095-4dannjjm 2762 8 collected collect VBN cord-023095-4dannjjm 2762 9 from from IN cord-023095-4dannjjm 2762 10 7 7 CD cord-023095-4dannjjm 2762 11 dogs dog NNS cord-023095-4dannjjm 2762 12 with with IN cord-023095-4dannjjm 2762 13 HGE HGE NNP cord-023095-4dannjjm 2762 14 . . . cord-023095-4dannjjm 2763 1 Fecal fecal JJ cord-023095-4dannjjm 2763 2 CP CP NNP cord-023095-4dannjjm 2763 3 , , , cord-023095-4dannjjm 2763 4 A12 A12 NNP cord-023095-4dannjjm 2763 5 , , , cord-023095-4dannjjm 2763 6 and and CC cord-023095-4dannjjm 2763 7 a a DT cord-023095-4dannjjm 2763 8 1 1 CD cord-023095-4dannjjm 2763 9 -PI -pi NN cord-023095-4dannjjm 2763 10 concentrations concentration NNS cord-023095-4dannjjm 2763 11 were be VBD cord-023095-4dannjjm 2763 12 measured measure VBN cord-023095-4dannjjm 2763 13 by by IN cord-023095-4dannjjm 2763 14 in in IN cord-023095-4dannjjm 2763 15 - - HYPH cord-023095-4dannjjm 2763 16 house house NN cord-023095-4dannjjm 2763 17 immunoassays immunoassay NNS cord-023095-4dannjjm 2763 18 . . . cord-023095-4dannjjm 2764 1 Bacterial bacterial JJ cord-023095-4dannjjm 2764 2 DNA DNA NNP cord-023095-4dannjjm 2764 3 was be VBD cord-023095-4dannjjm 2764 4 extracted extract VBN cord-023095-4dannjjm 2764 5 from from IN cord-023095-4dannjjm 2764 6 each each DT cord-023095-4dannjjm 2764 7 fecal fecal JJ cord-023095-4dannjjm 2764 8 sample sample NN cord-023095-4dannjjm 2764 9 and and CC cord-023095-4dannjjm 2764 10 was be VBD cord-023095-4dannjjm 2764 11 analyzed analyze VBN cord-023095-4dannjjm 2764 12 for for IN cord-023095-4dannjjm 2764 13 Faecalibacterium Faecalibacterium NNP cord-023095-4dannjjm 2764 14 spp spp NNS cord-023095-4dannjjm 2764 15 . . . cord-023095-4dannjjm 2765 1 , , , cord-023095-4dannjjm 2765 2 Proteobacteria Proteobacteria NNP cord-023095-4dannjjm 2765 3 , , , cord-023095-4dannjjm 2765 4 Rumino Rumino NNP cord-023095-4dannjjm 2765 5 - - HYPH cord-023095-4dannjjm 2765 6 coccaceae coccaceae NNP cord-023095-4dannjjm 2765 7 , , , cord-023095-4dannjjm 2765 8 and and CC cord-023095-4dannjjm 2765 9 Bifidobacterium Bifidobacterium NNP cord-023095-4dannjjm 2765 10 spp spp NNS cord-023095-4dannjjm 2765 11 . . . cord-023095-4dannjjm 2766 1 using use VBG cord-023095-4dannjjm 2766 2 quantitative quantitative JJ cord-023095-4dannjjm 2766 3 PCR PCR NNP cord-023095-4dannjjm 2766 4 assays assay NNS cord-023095-4dannjjm 2766 5 . . . cord-023095-4dannjjm 2767 1 Concentrations concentration NNS cord-023095-4dannjjm 2767 2 of of IN cord-023095-4dannjjm 2767 3 fecal fecal JJ cord-023095-4dannjjm 2767 4 CP cp NN cord-023095-4dannjjm 2767 5 , , , cord-023095-4dannjjm 2767 6 A12 A12 NNP cord-023095-4dannjjm 2767 7 , , , cord-023095-4dannjjm 2767 8 and and CC cord-023095-4dannjjm 2767 9 a a DT cord-023095-4dannjjm 2767 10 1 1 CD cord-023095-4dannjjm 2767 11 -PI -pi NN cord-023095-4dannjjm 2767 12 , , , cord-023095-4dannjjm 2767 13 and and CC cord-023095-4dannjjm 2767 14 the the DT cord-023095-4dannjjm 2767 15 abundance abundance NN cord-023095-4dannjjm 2767 16 of of IN cord-023095-4dannjjm 2767 17 bacterial bacterial JJ cord-023095-4dannjjm 2767 18 DNA dna NN cord-023095-4dannjjm 2767 19 were be VBD cord-023095-4dannjjm 2767 20 compared compare VBN cord-023095-4dannjjm 2767 21 using use VBG cord-023095-4dannjjm 2767 22 a a DT cord-023095-4dannjjm 2767 23 Friedman Friedman NNP cord-023095-4dannjjm 2767 24 test test NN cord-023095-4dannjjm 2767 25 with with IN cord-023095-4dannjjm 2767 26 Dunn Dunn NNP cord-023095-4dannjjm 2767 27 's 's POS cord-023095-4dannjjm 2767 28 post post JJ cord-023095-4dannjjm 2767 29 - - JJ cord-023095-4dannjjm 2767 30 hoc hoc JJ cord-023095-4dannjjm 2767 31 tests test NNS cord-023095-4dannjjm 2767 32 . . . cord-023095-4dannjjm 2768 1 Significance significance NN cord-023095-4dannjjm 2768 2 was be VBD cord-023095-4dannjjm 2768 3 set set VBN cord-023095-4dannjjm 2768 4 at at IN cord-023095-4dannjjm 2768 5 p p NN cord-023095-4dannjjm 2768 6 o o NN cord-023095-4dannjjm 2768 7 0.05 0.05 CD cord-023095-4dannjjm 2768 8 . . . cord-023095-4dannjjm 2769 1 At at IN cord-023095-4dannjjm 2769 2 the the DT cord-023095-4dannjjm 2769 3 time time NN cord-023095-4dannjjm 2769 4 of of IN cord-023095-4dannjjm 2769 5 diagnosis diagnosis NN cord-023095-4dannjjm 2769 6 ( ( -LRB- cord-023095-4dannjjm 2769 7 day day NN cord-023095-4dannjjm 2769 8 1 1 CD cord-023095-4dannjjm 2769 9 ) ) -RRB- cord-023095-4dannjjm 2769 10 , , , cord-023095-4dannjjm 2769 11 fecal fecal JJ cord-023095-4dannjjm 2769 12 CP cp NN cord-023095-4dannjjm 2769 13 , , , cord-023095-4dannjjm 2769 14 A12 A12 NNP cord-023095-4dannjjm 2769 15 , , , cord-023095-4dannjjm 2769 16 and and CC cord-023095-4dannjjm 2769 17 a a DT cord-023095-4dannjjm 2769 18 1 1 CD cord-023095-4dannjjm 2769 19 -PI -pi NN cord-023095-4dannjjm 2769 20 were be VBD cord-023095-4dannjjm 2769 21 above above IN cord-023095-4dannjjm 2769 22 the the DT cord-023095-4dannjjm 2769 23 suggested suggest VBN cord-023095-4dannjjm 2769 24 reference reference NN cord-023095-4dannjjm 2769 25 intervals interval NNS cord-023095-4dannjjm 2769 26 in in IN cord-023095-4dannjjm 2769 27 6 6 CD cord-023095-4dannjjm 2769 28 , , , cord-023095-4dannjjm 2769 29 6 6 CD cord-023095-4dannjjm 2769 30 , , , cord-023095-4dannjjm 2769 31 and and CC cord-023095-4dannjjm 2769 32 5 5 CD cord-023095-4dannjjm 2769 33 of of IN cord-023095-4dannjjm 2769 34 the the DT cord-023095-4dannjjm 2769 35 7 7 CD cord-023095-4dannjjm 2769 36 dogs dog NNS cord-023095-4dannjjm 2769 37 , , , cord-023095-4dannjjm 2769 38 respectively respectively RB cord-023095-4dannjjm 2769 39 . . . cord-023095-4dannjjm 2770 1 Until until IN cord-023095-4dannjjm 2770 2 day day NN cord-023095-4dannjjm 2770 3 3 3 CD cord-023095-4dannjjm 2770 4 , , , cord-023095-4dannjjm 2770 5 this this DT cord-023095-4dannjjm 2770 6 number number NN cord-023095-4dannjjm 2770 7 decreased decrease VBD cord-023095-4dannjjm 2770 8 to to IN cord-023095-4dannjjm 2770 9 2 2 CD cord-023095-4dannjjm 2770 10 , , , cord-023095-4dannjjm 2770 11 1 1 CD cord-023095-4dannjjm 2770 12 , , , cord-023095-4dannjjm 2770 13 and and CC cord-023095-4dannjjm 2770 14 4 4 CD cord-023095-4dannjjm 2770 15 , , , cord-023095-4dannjjm 2770 16 respectively respectively RB cord-023095-4dannjjm 2770 17 . . . cord-023095-4dannjjm 2771 1 Decreases decrease NNS cord-023095-4dannjjm 2771 2 in in IN cord-023095-4dannjjm 2771 3 concentrations concentration NNS cord-023095-4dannjjm 2771 4 were be VBD cord-023095-4dannjjm 2771 5 significant significant JJ cord-023095-4dannjjm 2771 6 between between IN cord-023095-4dannjjm 2771 7 days day NNS cord-023095-4dannjjm 2771 8 2 2 CD cord-023095-4dannjjm 2771 9 and and CC cord-023095-4dannjjm 2771 10 3 3 CD cord-023095-4dannjjm 2771 11 for for IN cord-023095-4dannjjm 2771 12 A12 A12 NNP cord-023095-4dannjjm 2771 13 ( ( -LRB- cord-023095-4dannjjm 2771 14 p p NN cord-023095-4dannjjm 2771 15 5 5 CD cord-023095-4dannjjm 2771 16 0.016 0.016 CD cord-023095-4dannjjm 2771 17 ) ) -RRB- cord-023095-4dannjjm 2771 18 , , , cord-023095-4dannjjm 2771 19 and and CC cord-023095-4dannjjm 2771 20 between between IN cord-023095-4dannjjm 2771 21 days day NNS cord-023095-4dannjjm 2771 22 1 1 CD cord-023095-4dannjjm 2771 23 and and CC cord-023095-4dannjjm 2771 24 3 3 CD cord-023095-4dannjjm 2771 25 for for IN cord-023095-4dannjjm 2771 26 a a DT cord-023095-4dannjjm 2771 27 1 1 CD cord-023095-4dannjjm 2771 28 -PI -pi NN cord-023095-4dannjjm 2772 1 ( ( -LRB- cord-023095-4dannjjm 2772 2 p p NN cord-023095-4dannjjm 2772 3 5 5 CD cord-023095-4dannjjm 2772 4 0.012 0.012 CD cord-023095-4dannjjm 2772 5 ) ) -RRB- cord-023095-4dannjjm 2772 6 , , , cord-023095-4dannjjm 2772 7 but but CC cord-023095-4dannjjm 2772 8 not not RB cord-023095-4dannjjm 2772 9 for for IN cord-023095-4dannjjm 2772 10 CP CP NNP cord-023095-4dannjjm 2772 11 despite despite IN cord-023095-4dannjjm 2772 12 a a DT cord-023095-4dannjjm 2772 13 trend trend NN cord-023095-4dannjjm 2772 14 ( ( -LRB- cord-023095-4dannjjm 2772 15 p p NN cord-023095-4dannjjm 2772 16 5 5 CD cord-023095-4dannjjm 2772 17 0.085 0.085 CD cord-023095-4dannjjm 2772 18 ) ) -RRB- cord-023095-4dannjjm 2772 19 . . . cord-023095-4dannjjm 2773 1 No no DT cord-023095-4dannjjm 2773 2 differences difference NNS cord-023095-4dannjjm 2773 3 in in IN cord-023095-4dannjjm 2773 4 the the DT cord-023095-4dannjjm 2773 5 abundance abundance NN cord-023095-4dannjjm 2773 6 of of IN cord-023095-4dannjjm 2773 7 Faecalibacterium Faecalibacterium NNP cord-023095-4dannjjm 2773 8 spp spp NNS cord-023095-4dannjjm 2773 9 . . . cord-023095-4dannjjm 2774 1 ( ( -LRB- cord-023095-4dannjjm 2774 2 p p NN cord-023095-4dannjjm 2774 3 5 5 CD cord-023095-4dannjjm 2774 4 0.085 0.085 CD cord-023095-4dannjjm 2774 5 ) ) -RRB- cord-023095-4dannjjm 2774 6 , , , cord-023095-4dannjjm 2774 7 Bifidobacterium bifidobacterium NN cord-023095-4dannjjm 2774 8 spp spp NNS cord-023095-4dannjjm 2774 9 . . . cord-023095-4dannjjm 2775 1 ( ( -LRB- cord-023095-4dannjjm 2775 2 p p NN cord-023095-4dannjjm 2775 3 5 5 CD cord-023095-4dannjjm 2775 4 0.192 0.192 CD cord-023095-4dannjjm 2775 5 ) ) -RRB- cord-023095-4dannjjm 2775 6 , , , cord-023095-4dannjjm 2775 7 or or CC cord-023095-4dannjjm 2775 8 Proteobacteria Proteobacteria NNP cord-023095-4dannjjm 2775 9 ( ( -LRB- cord-023095-4dannjjm 2775 10 p p NN cord-023095-4dannjjm 2775 11 5 5 CD cord-023095-4dannjjm 2775 12 0.305 0.305 CD cord-023095-4dannjjm 2775 13 ) ) -RRB- cord-023095-4dannjjm 2775 14 were be VBD cord-023095-4dannjjm 2775 15 observed observe VBN cord-023095-4dannjjm 2775 16 . . . cord-023095-4dannjjm 2776 1 However however RB cord-023095-4dannjjm 2776 2 , , , cord-023095-4dannjjm 2776 3 the the DT cord-023095-4dannjjm 2776 4 abundance abundance NN cord-023095-4dannjjm 2776 5 of of IN cord-023095-4dannjjm 2776 6 Rumino rumino NN cord-023095-4dannjjm 2776 7 - - HYPH cord-023095-4dannjjm 2776 8 coccaceae coccaceae NNP cord-023095-4dannjjm 2776 9 was be VBD cord-023095-4dannjjm 2776 10 significantly significantly RB cord-023095-4dannjjm 2776 11 lower low JJR cord-023095-4dannjjm 2776 12 on on IN cord-023095-4dannjjm 2776 13 day day NN cord-023095-4dannjjm 2776 14 3 3 CD cord-023095-4dannjjm 2776 15 when when WRB cord-023095-4dannjjm 2776 16 compared compare VBN cord-023095-4dannjjm 2776 17 to to IN cord-023095-4dannjjm 2776 18 day day NN cord-023095-4dannjjm 2776 19 2 2 CD cord-023095-4dannjjm 2776 20 ( ( -LRB- cord-023095-4dannjjm 2776 21 p p NN cord-023095-4dannjjm 2776 22 5 5 CD cord-023095-4dannjjm 2776 23 0.008 0.008 CD cord-023095-4dannjjm 2776 24 ) ) -RRB- cord-023095-4dannjjm 2776 25 . . . cord-023095-4dannjjm 2777 1 In in IN cord-023095-4dannjjm 2777 2 this this DT cord-023095-4dannjjm 2777 3 study study NN cord-023095-4dannjjm 2777 4 , , , cord-023095-4dannjjm 2777 5 fecal fecal JJ cord-023095-4dannjjm 2777 6 markers marker NNS cord-023095-4dannjjm 2777 7 of of IN cord-023095-4dannjjm 2777 8 inflammation inflammation NN cord-023095-4dannjjm 2777 9 and and CC cord-023095-4dannjjm 2777 10 GI GI NNP cord-023095-4dannjjm 2777 11 protein protein NN cord-023095-4dannjjm 2777 12 loss loss NN cord-023095-4dannjjm 2777 13 were be VBD cord-023095-4dannjjm 2777 14 increased increase VBN cord-023095-4dannjjm 2777 15 in in IN cord-023095-4dannjjm 2777 16 dogs dog NNS cord-023095-4dannjjm 2777 17 with with IN cord-023095-4dannjjm 2777 18 HGE HGE NNP cord-023095-4dannjjm 2777 19 . . . cord-023095-4dannjjm 2778 1 Although although IN cord-023095-4dannjjm 2778 2 the the DT cord-023095-4dannjjm 2778 3 number number NN cord-023095-4dannjjm 2778 4 of of IN cord-023095-4dannjjm 2778 5 patients patient NNS cord-023095-4dannjjm 2778 6 was be VBD cord-023095-4dannjjm 2778 7 small small JJ cord-023095-4dannjjm 2778 8 , , , cord-023095-4dannjjm 2778 9 following follow VBG cord-023095-4dannjjm 2778 10 initiation initiation NN cord-023095-4dannjjm 2778 11 of of IN cord-023095-4dannjjm 2778 12 treatment treatment NN cord-023095-4dannjjm 2778 13 , , , cord-023095-4dannjjm 2778 14 two two CD cord-023095-4dannjjm 2778 15 of of IN cord-023095-4dannjjm 2778 16 the the DT cord-023095-4dannjjm 2778 17 markers marker NNS cord-023095-4dannjjm 2778 18 decreased decrease VBD cord-023095-4dannjjm 2778 19 significantly significantly RB cord-023095-4dannjjm 2778 20 . . . cord-023095-4dannjjm 2779 1 These these DT cord-023095-4dannjjm 2779 2 results result NNS cord-023095-4dannjjm 2779 3 suggest suggest VBP cord-023095-4dannjjm 2779 4 a a DT cord-023095-4dannjjm 2779 5 loss loss NN cord-023095-4dannjjm 2779 6 of of IN cord-023095-4dannjjm 2779 7 protein protein NN cord-023095-4dannjjm 2779 8 into into IN cord-023095-4dannjjm 2779 9 the the DT cord-023095-4dannjjm 2779 10 GI GI NNP cord-023095-4dannjjm 2779 11 tract tract NN cord-023095-4dannjjm 2779 12 at at IN cord-023095-4dannjjm 2779 13 the the DT cord-023095-4dannjjm 2779 14 onset onset NN cord-023095-4dannjjm 2779 15 of of IN cord-023095-4dannjjm 2779 16 HGE HGE NNP cord-023095-4dannjjm 2779 17 . . . cord-023095-4dannjjm 2780 1 The the DT cord-023095-4dannjjm 2780 2 lack lack NN cord-023095-4dannjjm 2780 3 of of IN cord-023095-4dannjjm 2780 4 significant significant JJ cord-023095-4dannjjm 2780 5 increases increase NNS cord-023095-4dannjjm 2780 6 of of IN cord-023095-4dannjjm 2780 7 Faecalibacterium Faecalibacterium NNP cord-023095-4dannjjm 2780 8 spp spp NNS cord-023095-4dannjjm 2780 9 . . . cord-023095-4dannjjm 2781 1 , , , cord-023095-4dannjjm 2781 2 Bifidobacterium Bifidobacterium NNP cord-023095-4dannjjm 2781 3 spp spp NNS cord-023095-4dannjjm 2781 4 . . . cord-023095-4dannjjm 2782 1 , , , cord-023095-4dannjjm 2783 1 and and CC cord-023095-4dannjjm 2783 2 Ruminococcaceae Ruminococcaceae NNP cord-023095-4dannjjm 2783 3 , , , cord-023095-4dannjjm 2783 4 and and CC cord-023095-4dannjjm 2783 5 decreases decrease VBZ cord-023095-4dannjjm 2783 6 in in IN cord-023095-4dannjjm 2783 7 Proteobacteria Proteobacteria NNP cord-023095-4dannjjm 2783 8 may may MD cord-023095-4dannjjm 2783 9 suggest suggest VB cord-023095-4dannjjm 2783 10 GI GI NNP cord-023095-4dannjjm 2783 11 dysbiosis dysbiosis NN cord-023095-4dannjjm 2783 12 . . . cord-023095-4dannjjm 2784 1 Further further JJ cord-023095-4dannjjm 2784 2 longitudinal longitudinal JJ cord-023095-4dannjjm 2784 3 studies study NNS cord-023095-4dannjjm 2784 4 are be VBP cord-023095-4dannjjm 2784 5 needed need VBN cord-023095-4dannjjm 2784 6 and and CC cord-023095-4dannjjm 2784 7 are be VBP cord-023095-4dannjjm 2784 8 currently currently RB cord-023095-4dannjjm 2784 9 under under IN cord-023095-4dannjjm 2784 10 way way NN cord-023095-4dannjjm 2784 11 to to TO cord-023095-4dannjjm 2784 12 evaluate evaluate VB cord-023095-4dannjjm 2784 13 GI GI NNP cord-023095-4dannjjm 2784 14 dysbiosis dysbiosis NN cord-023095-4dannjjm 2784 15 in in IN cord-023095-4dannjjm 2784 16 canine canine JJ cord-023095-4dannjjm 2784 17 HGE hge NN cord-023095-4dannjjm 2784 18 patients patient NNS cord-023095-4dannjjm 2784 19 . . . cord-023095-4dannjjm 2785 1 The the DT cord-023095-4dannjjm 2785 2 most most RBS cord-023095-4dannjjm 2785 3 recent recent JJ cord-023095-4dannjjm 2785 4 antiemetic antiemetic NN cord-023095-4dannjjm 2785 5 approved approve VBN cord-023095-4dannjjm 2785 6 for for IN cord-023095-4dannjjm 2785 7 use use NN cord-023095-4dannjjm 2785 8 in in IN cord-023095-4dannjjm 2785 9 dogs dog NNS cord-023095-4dannjjm 2785 10 is be VBZ cord-023095-4dannjjm 2785 11 maropitant maropitant NN cord-023095-4dannjjm 2785 12 citrate citrate NNP cord-023095-4dannjjm 2785 13 ( ( -LRB- cord-023095-4dannjjm 2786 1 Cerenia Cerenia NNP cord-023095-4dannjjm 2786 2 s s POS cord-023095-4dannjjm 2786 3 , , , cord-023095-4dannjjm 2786 4 Pfizer Pfizer NNP cord-023095-4dannjjm 2786 5 Animal Animal NNP cord-023095-4dannjjm 2786 6 Health Health NNP cord-023095-4dannjjm 2786 7 ) ) -RRB- cord-023095-4dannjjm 2786 8 . . . cord-023095-4dannjjm 2787 1 Maropitant maropitant NN cord-023095-4dannjjm 2787 2 is be VBZ cord-023095-4dannjjm 2787 3 a a DT cord-023095-4dannjjm 2787 4 selective selective JJ cord-023095-4dannjjm 2787 5 NK1 nk1 JJ cord-023095-4dannjjm 2787 6 receptor receptor NN cord-023095-4dannjjm 2787 7 antagonist antagonist NN cord-023095-4dannjjm 2787 8 that that WDT cord-023095-4dannjjm 2787 9 acts act VBZ cord-023095-4dannjjm 2787 10 by by IN cord-023095-4dannjjm 2787 11 blocking block VBG cord-023095-4dannjjm 2787 12 the the DT cord-023095-4dannjjm 2787 13 binding binding NN cord-023095-4dannjjm 2787 14 of of IN cord-023095-4dannjjm 2787 15 substance substance NN cord-023095-4dannjjm 2787 16 - - HYPH cord-023095-4dannjjm 2787 17 P p NN cord-023095-4dannjjm 2787 18 within within IN cord-023095-4dannjjm 2787 19 the the DT cord-023095-4dannjjm 2787 20 emetic emetic JJ cord-023095-4dannjjm 2787 21 center center NN cord-023095-4dannjjm 2787 22 and and CC cord-023095-4dannjjm 2787 23 chemoreceptor chemoreceptor NNP cord-023095-4dannjjm 2787 24 trigger trigger NN cord-023095-4dannjjm 2787 25 zone zone NN cord-023095-4dannjjm 2787 26 . . . cord-023095-4dannjjm 2788 1 Label Label NNP cord-023095-4dannjjm 2788 2 dosage dosage NN cord-023095-4dannjjm 2788 3 recommendations recommendation NNS cord-023095-4dannjjm 2788 4 for for IN cord-023095-4dannjjm 2788 5 maropitant maropitant NN cord-023095-4dannjjm 2788 6 citrate citrate NNP cord-023095-4dannjjm 2788 7 are be VBP cord-023095-4dannjjm 2788 8 1 1 CD cord-023095-4dannjjm 2788 9 mg/ mg/ NN cord-023095-4dannjjm 2788 10 kg kg NNP cord-023095-4dannjjm 2788 11 SC SC NNP cord-023095-4dannjjm 2788 12 or or CC cord-023095-4dannjjm 2788 13 2 2 CD cord-023095-4dannjjm 2788 14 mg mg NNP cord-023095-4dannjjm 2788 15 / / SYM cord-023095-4dannjjm 2788 16 kg kg XX cord-023095-4dannjjm 2788 17 orally orally RB cord-023095-4dannjjm 2788 18 once once RB cord-023095-4dannjjm 2788 19 daily daily RB cord-023095-4dannjjm 2788 20 for for IN cord-023095-4dannjjm 2788 21 up up IN cord-023095-4dannjjm 2788 22 to to TO cord-023095-4dannjjm 2788 23 5 5 CD cord-023095-4dannjjm 2788 24 consecutive consecutive JJ cord-023095-4dannjjm 2788 25 days day NNS cord-023095-4dannjjm 2788 26 ( ( -LRB- cord-023095-4dannjjm 2788 27 acute acute JJ cord-023095-4dannjjm 2788 28 emesis emesis NN cord-023095-4dannjjm 2788 29 ) ) -RRB- cord-023095-4dannjjm 2788 30 and and CC cord-023095-4dannjjm 2788 31 8 8 CD cord-023095-4dannjjm 2788 32 mg mg NN cord-023095-4dannjjm 2788 33 / / SYM cord-023095-4dannjjm 2788 34 kg kg XX cord-023095-4dannjjm 2788 35 orally orally RB cord-023095-4dannjjm 2788 36 once once RB cord-023095-4dannjjm 2788 37 daily daily RB cord-023095-4dannjjm 2788 38 for for IN cord-023095-4dannjjm 2788 39 up up IN cord-023095-4dannjjm 2788 40 to to TO cord-023095-4dannjjm 2788 41 2 2 CD cord-023095-4dannjjm 2788 42 consecutive consecutive JJ cord-023095-4dannjjm 2788 43 days day NNS cord-023095-4dannjjm 2788 44 ( ( -LRB- cord-023095-4dannjjm 2788 45 motion motion NN cord-023095-4dannjjm 2788 46 sickness sickness NN cord-023095-4dannjjm 2788 47 ) ) -RRB- cord-023095-4dannjjm 2788 48 . . . cord-023095-4dannjjm 2789 1 The the DT cord-023095-4dannjjm 2789 2 study study NN cord-023095-4dannjjm 2789 3 objective objective NN cord-023095-4dannjjm 2789 4 was be VBD cord-023095-4dannjjm 2789 5 to to TO cord-023095-4dannjjm 2789 6 determine determine VB cord-023095-4dannjjm 2789 7 when when WRB cord-023095-4dannjjm 2789 8 steady steady JJ cord-023095-4dannjjm 2789 9 - - HYPH cord-023095-4dannjjm 2789 10 state state NN cord-023095-4dannjjm 2789 11 is be VBZ cord-023095-4dannjjm 2789 12 reached reach VBN cord-023095-4dannjjm 2789 13 and and CC cord-023095-4dannjjm 2789 14 the the DT cord-023095-4dannjjm 2789 15 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 2789 16 of of IN cord-023095-4dannjjm 2789 17 maropitant maropitant NNP cord-023095-4dannjjm 2789 18 administered administer VBN cord-023095-4dannjjm 2789 19 at at IN cord-023095-4dannjjm 2789 20 label label NN cord-023095-4dannjjm 2789 21 oral oral JJ cord-023095-4dannjjm 2789 22 dosages dosage NNS cord-023095-4dannjjm 2789 23 once once RB cord-023095-4dannjjm 2789 24 daily daily RB cord-023095-4dannjjm 2789 25 for for IN cord-023095-4dannjjm 2789 26 14 14 CD cord-023095-4dannjjm 2789 27 consecutive consecutive JJ cord-023095-4dannjjm 2789 28 days day NNS cord-023095-4dannjjm 2789 29 . . . cord-023095-4dannjjm 2790 1 Two two CD cord-023095-4dannjjm 2790 2 groups group NNS cord-023095-4dannjjm 2790 3 of of IN cord-023095-4dannjjm 2790 4 eight eight CD cord-023095-4dannjjm 2790 5 healthy healthy JJ cord-023095-4dannjjm 2790 6 beagles beagle NNS cord-023095-4dannjjm 2790 7 were be VBD cord-023095-4dannjjm 2790 8 administered administer VBN cord-023095-4dannjjm 2790 9 maropitant maropitant NN cord-023095-4dannjjm 2790 10 citrate citrate NN cord-023095-4dannjjm 2790 11 at at IN cord-023095-4dannjjm 2790 12 2 2 CD cord-023095-4dannjjm 2790 13 or or CC cord-023095-4dannjjm 2790 14 8 8 CD cord-023095-4dannjjm 2790 15 mg mg NN cord-023095-4dannjjm 2790 16 / / SYM cord-023095-4dannjjm 2790 17 kg kg XX cord-023095-4dannjjm 2790 18 orally orally RB cord-023095-4dannjjm 2790 19 once once RB cord-023095-4dannjjm 2790 20 daily daily RB cord-023095-4dannjjm 2790 21 for for IN cord-023095-4dannjjm 2790 22 14 14 CD cord-023095-4dannjjm 2790 23 days day NNS cord-023095-4dannjjm 2790 24 . . . cord-023095-4dannjjm 2791 1 Concentrations concentration NNS cord-023095-4dannjjm 2791 2 of of IN cord-023095-4dannjjm 2791 3 maropitant maropitant NN cord-023095-4dannjjm 2791 4 and and CC cord-023095-4dannjjm 2791 5 its -PRON- PRP$ cord-023095-4dannjjm 2791 6 metabolite metabolite NN cord-023095-4dannjjm 2791 7 were be VBD cord-023095-4dannjjm 2791 8 measured measure VBN cord-023095-4dannjjm 2791 9 in in IN cord-023095-4dannjjm 2791 10 plasma plasma NN cord-023095-4dannjjm 2791 11 using use VBG cord-023095-4dannjjm 2791 12 a a DT cord-023095-4dannjjm 2791 13 LC LC NNP cord-023095-4dannjjm 2791 14 - - HYPH cord-023095-4dannjjm 2791 15 MS MS NNP cord-023095-4dannjjm 2791 16 / / SYM cord-023095-4dannjjm 2791 17 MS MS NNP cord-023095-4dannjjm 2791 18 assay assay NN cord-023095-4dannjjm 2791 19 . . . cord-023095-4dannjjm 2792 1 Pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 2792 2 parameters parameter NNS cord-023095-4dannjjm 2792 3 were be VBD cord-023095-4dannjjm 2792 4 estimated estimate VBN cord-023095-4dannjjm 2792 5 using use VBG cord-023095-4dannjjm 2792 6 non non JJ cord-023095-4dannjjm 2792 7 - - JJ cord-023095-4dannjjm 2792 8 compartmental compartmental JJ cord-023095-4dannjjm 2792 9 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 2792 10 techniques technique NNS cord-023095-4dannjjm 2792 11 and and CC cord-023095-4dannjjm 2792 12 a a DT cord-023095-4dannjjm 2792 13 modeling modeling NN cord-023095-4dannjjm 2792 14 approach approach NN cord-023095-4dannjjm 2792 15 was be VBD cord-023095-4dannjjm 2792 16 used use VBN cord-023095-4dannjjm 2792 17 to to TO cord-023095-4dannjjm 2792 18 estimate estimate VB cord-023095-4dannjjm 2792 19 steady steady JJ cord-023095-4dannjjm 2792 20 - - HYPH cord-023095-4dannjjm 2792 21 state state NN cord-023095-4dannjjm 2792 22 . . . cord-023095-4dannjjm 2793 1 The the DT cord-023095-4dannjjm 2793 2 accumulation accumulation NN cord-023095-4dannjjm 2793 3 ratio ratio NN cord-023095-4dannjjm 2793 4 for for IN cord-023095-4dannjjm 2793 5 maropitant maropitant NN cord-023095-4dannjjm 2793 6 was be VBD cord-023095-4dannjjm 2793 7 2.46 2.46 CD cord-023095-4dannjjm 2793 8 ( ( -LRB- cord-023095-4dannjjm 2793 9 AUC0 AUC0 NNP cord-023095-4dannjjm 2793 10 - - HYPH cord-023095-4dannjjm 2793 11 24 24 CD cord-023095-4dannjjm 2793 12 ) ) -RRB- cord-023095-4dannjjm 2793 13 and and CC cord-023095-4dannjjm 2793 14 2.03 2.03 CD cord-023095-4dannjjm 2793 15 ( ( -LRB- cord-023095-4dannjjm 2793 16 Cmax Cmax NNP cord-023095-4dannjjm 2793 17 ) ) -RRB- cord-023095-4dannjjm 2793 18 for for IN cord-023095-4dannjjm 2793 19 the the DT cord-023095-4dannjjm 2793 20 2 2 CD cord-023095-4dannjjm 2793 21 mg mg NNP cord-023095-4dannjjm 2793 22 / / SYM cord-023095-4dannjjm 2793 23 kg kg NN cord-023095-4dannjjm 2793 24 dose dose NN cord-023095-4dannjjm 2793 25 ; ; : cord-023095-4dannjjm 2793 26 and and CC cord-023095-4dannjjm 2793 27 4.81 4.81 CD cord-023095-4dannjjm 2793 28 ( ( -LRB- cord-023095-4dannjjm 2793 29 AUC0 AUC0 NNP cord-023095-4dannjjm 2793 30 - - HYPH cord-023095-4dannjjm 2793 31 24 24 CD cord-023095-4dannjjm 2793 32 ) ) -RRB- cord-023095-4dannjjm 2793 33 and and CC cord-023095-4dannjjm 2793 34 2.77 2.77 CD cord-023095-4dannjjm 2793 35 ( ( -LRB- cord-023095-4dannjjm 2793 36 Cmax Cmax NNP cord-023095-4dannjjm 2793 37 ) ) -RRB- cord-023095-4dannjjm 2793 38 for for IN cord-023095-4dannjjm 2793 39 the the DT cord-023095-4dannjjm 2793 40 8 8 CD cord-023095-4dannjjm 2793 41 mg mg NNP cord-023095-4dannjjm 2793 42 / / SYM cord-023095-4dannjjm 2793 43 kg kg NNS cord-023095-4dannjjm 2793 44 dose dose VBD cord-023095-4dannjjm 2793 45 after after IN cord-023095-4dannjjm 2793 46 14 14 CD cord-023095-4dannjjm 2793 47 days day NNS cord-023095-4dannjjm 2793 48 . . . cord-023095-4dannjjm 2794 1 The the DT cord-023095-4dannjjm 2794 2 model model NN cord-023095-4dannjjm 2794 3 estimate estimate NN cord-023095-4dannjjm 2794 4 for for IN cord-023095-4dannjjm 2794 5 the the DT cord-023095-4dannjjm 2794 6 number number NN cord-023095-4dannjjm 2794 7 of of IN cord-023095-4dannjjm 2794 8 doses dose NNS cord-023095-4dannjjm 2794 9 required require VBN cord-023095-4dannjjm 2794 10 to to TO cord-023095-4dannjjm 2794 11 reach reach VB cord-023095-4dannjjm 2794 12 90 90 CD cord-023095-4dannjjm 2794 13 % % NN cord-023095-4dannjjm 2794 14 of of IN cord-023095-4dannjjm 2794 15 steady steady JJ cord-023095-4dannjjm 2794 16 - - HYPH cord-023095-4dannjjm 2794 17 state state NN cord-023095-4dannjjm 2794 18 was be VBD cord-023095-4dannjjm 2794 19 4.30 4.30 CD cord-023095-4dannjjm 2794 20 for for IN cord-023095-4dannjjm 2794 21 2 2 CD cord-023095-4dannjjm 2794 22 mg mg NNP cord-023095-4dannjjm 2794 23 / / SYM cord-023095-4dannjjm 2794 24 kg kg NNS cord-023095-4dannjjm 2794 25 and and CC cord-023095-4dannjjm 2794 26 8.09 8.09 CD cord-023095-4dannjjm 2794 27 for for IN cord-023095-4dannjjm 2794 28 8 8 CD cord-023095-4dannjjm 2794 29 mg mg NNP cord-023095-4dannjjm 2794 30 / / SYM cord-023095-4dannjjm 2794 31 kg kg NNS cord-023095-4dannjjm 2794 32 . . . cord-023095-4dannjjm 2795 1 Three three CD cord-023095-4dannjjm 2795 2 dogs dog NNS cord-023095-4dannjjm 2795 3 experienced experience VBD cord-023095-4dannjjm 2795 4 a a DT cord-023095-4dannjjm 2795 5 single single JJ cord-023095-4dannjjm 2795 6 episode episode NN cord-023095-4dannjjm 2795 7 of of IN cord-023095-4dannjjm 2795 8 vomiting vomiting NN cord-023095-4dannjjm 2795 9 . . . cord-023095-4dannjjm 2796 1 Dosing dosing NN cord-023095-4dannjjm 2796 2 maropitant maropitant NN cord-023095-4dannjjm 2796 3 citrate citrate NN cord-023095-4dannjjm 2796 4 beyond beyond IN cord-023095-4dannjjm 2796 5 the the DT cord-023095-4dannjjm 2796 6 label label NN cord-023095-4dannjjm 2796 7 duration duration NN cord-023095-4dannjjm 2796 8 was be VBD cord-023095-4dannjjm 2796 9 well well RB cord-023095-4dannjjm 2796 10 tolerated tolerate VBN cord-023095-4dannjjm 2796 11 by by IN cord-023095-4dannjjm 2796 12 healthy healthy JJ cord-023095-4dannjjm 2796 13 dogs dog NNS cord-023095-4dannjjm 2796 14 . . . cord-023095-4dannjjm 2797 1 Steady steady JJ cord-023095-4dannjjm 2797 2 - - HYPH cord-023095-4dannjjm 2797 3 state state NN cord-023095-4dannjjm 2797 4 was be VBD cord-023095-4dannjjm 2797 5 reached reach VBN cord-023095-4dannjjm 2797 6 after after IN cord-023095-4dannjjm 2797 7 approximately approximately RB cord-023095-4dannjjm 2797 8 4 4 CD cord-023095-4dannjjm 2797 9 doses dose NNS cord-023095-4dannjjm 2797 10 for for IN cord-023095-4dannjjm 2797 11 daily daily JJ cord-023095-4dannjjm 2797 12 2 2 CD cord-023095-4dannjjm 2797 13 mg mg NNP cord-023095-4dannjjm 2797 14 / / SYM cord-023095-4dannjjm 2797 15 kg kg NNS cord-023095-4dannjjm 2797 16 and and CC cord-023095-4dannjjm 2797 17 8 8 CD cord-023095-4dannjjm 2797 18 doses dose NNS cord-023095-4dannjjm 2797 19 for for IN cord-023095-4dannjjm 2797 20 daily daily JJ cord-023095-4dannjjm 2797 21 8 8 CD cord-023095-4dannjjm 2797 22 mg mg NNP cord-023095-4dannjjm 2797 23 / / SYM cord-023095-4dannjjm 2797 24 kg kg CD cord-023095-4dannjjm 2797 25 oral oral JJ cord-023095-4dannjjm 2797 26 dosing dosing NN cord-023095-4dannjjm 2797 27 . . . cord-023095-4dannjjm 2798 1 Previously previously RB cord-023095-4dannjjm 2798 2 presented present VBN cord-023095-4dannjjm 2798 3 at at IN cord-023095-4dannjjm 2798 4 the the DT cord-023095-4dannjjm 2798 5 Veterinary Veterinary NNP cord-023095-4dannjjm 2798 6 Cancer Cancer NNP cord-023095-4dannjjm 2798 7 Society Society NNP cord-023095-4dannjjm 2798 8 , , , cord-023095-4dannjjm 2798 9 November November NNP cord-023095-4dannjjm 2798 10 2010 2010 CD cord-023095-4dannjjm 2798 11 . . . cord-023095-4dannjjm 2799 1 Cobalamin Cobalamin NNP cord-023095-4dannjjm 2799 2 ( ( -LRB- cord-023095-4dannjjm 2799 3 vitamin vitamin NN cord-023095-4dannjjm 2799 4 B b NN cord-023095-4dannjjm 2799 5 12 12 CD cord-023095-4dannjjm 2799 6 ) ) -RRB- cord-023095-4dannjjm 2799 7 is be VBZ cord-023095-4dannjjm 2799 8 involved involve VBN cord-023095-4dannjjm 2799 9 in in IN cord-023095-4dannjjm 2799 10 a a DT cord-023095-4dannjjm 2799 11 variety variety NN cord-023095-4dannjjm 2799 12 of of IN cord-023095-4dannjjm 2799 13 metabolic metabolic JJ cord-023095-4dannjjm 2799 14 processes process NNS cord-023095-4dannjjm 2799 15 . . . cord-023095-4dannjjm 2800 1 Altered altered JJ cord-023095-4dannjjm 2800 2 serum serum NN cord-023095-4dannjjm 2800 3 cobalamin cobalamin NN cord-023095-4dannjjm 2800 4 concentrations concentration NNS cord-023095-4dannjjm 2800 5 have have VBP cord-023095-4dannjjm 2800 6 been be VBN cord-023095-4dannjjm 2800 7 observed observe VBN cord-023095-4dannjjm 2800 8 in in IN cord-023095-4dannjjm 2800 9 dogs dog NNS cord-023095-4dannjjm 2800 10 with with IN cord-023095-4dannjjm 2800 11 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2800 12 disorders disorder NNS cord-023095-4dannjjm 2800 13 , , , cord-023095-4dannjjm 2800 14 such such JJ cord-023095-4dannjjm 2800 15 as as IN cord-023095-4dannjjm 2800 16 exocrine exocrine JJ cord-023095-4dannjjm 2800 17 pancreatic pancreatic JJ cord-023095-4dannjjm 2800 18 insufficiency insufficiency NN cord-023095-4dannjjm 2800 19 ( ( -LRB- cord-023095-4dannjjm 2800 20 EPI EPI NNP cord-023095-4dannjjm 2800 21 ) ) -RRB- cord-023095-4dannjjm 2800 22 or or CC cord-023095-4dannjjm 2800 23 severe severe JJ cord-023095-4dannjjm 2800 24 and and CC cord-023095-4dannjjm 2800 25 longstanding longstanding JJ cord-023095-4dannjjm 2800 26 ileal ileal JJ cord-023095-4dannjjm 2800 27 disease disease NN cord-023095-4dannjjm 2800 28 . . . cord-023095-4dannjjm 2801 1 This this DT cord-023095-4dannjjm 2801 2 study study NN cord-023095-4dannjjm 2801 3 was be VBD cord-023095-4dannjjm 2801 4 conducted conduct VBN cord-023095-4dannjjm 2801 5 to to TO cord-023095-4dannjjm 2801 6 identify identify VB cord-023095-4dannjjm 2801 7 breeds breed NNS cord-023095-4dannjjm 2801 8 with with IN cord-023095-4dannjjm 2801 9 a a DT cord-023095-4dannjjm 2801 10 higher high JJR cord-023095-4dannjjm 2801 11 proportion proportion NN cord-023095-4dannjjm 2801 12 of of IN cord-023095-4dannjjm 2801 13 a a DT cord-023095-4dannjjm 2801 14 decreased decrease VBN cord-023095-4dannjjm 2801 15 serum serum NN cord-023095-4dannjjm 2801 16 cobalamin cobalamin NN cord-023095-4dannjjm 2801 17 concentration concentration NN cord-023095-4dannjjm 2801 18 that that WDT cord-023095-4dannjjm 2801 19 were be VBD cord-023095-4dannjjm 2801 20 submitted submit VBN cord-023095-4dannjjm 2801 21 to to IN cord-023095-4dannjjm 2801 22 the the DT cord-023095-4dannjjm 2801 23 Gastrointestinal Gastrointestinal NNP cord-023095-4dannjjm 2801 24 Laboratory Laboratory NNP cord-023095-4dannjjm 2801 25 . . . cord-023095-4dannjjm 2802 1 The the DT cord-023095-4dannjjm 2802 2 study study NN cord-023095-4dannjjm 2802 3 was be VBD cord-023095-4dannjjm 2802 4 also also RB cord-023095-4dannjjm 2802 5 aimed aim VBN cord-023095-4dannjjm 2802 6 at at IN cord-023095-4dannjjm 2802 7 investigating investigate VBG cord-023095-4dannjjm 2802 8 serum serum NN cord-023095-4dannjjm 2802 9 trypsin trypsin NN cord-023095-4dannjjm 2802 10 - - HYPH cord-023095-4dannjjm 2802 11 like like JJ cord-023095-4dannjjm 2802 12 immunoreactivity immunoreactivity NN cord-023095-4dannjjm 2802 13 ( ( -LRB- cord-023095-4dannjjm 2802 14 TLI TLI NNP cord-023095-4dannjjm 2802 15 ) ) -RRB- cord-023095-4dannjjm 2802 16 concentrations concentration NNS cord-023095-4dannjjm 2802 17 that that WDT cord-023095-4dannjjm 2802 18 were be VBD cord-023095-4dannjjm 2802 19 diagnostic diagnostic JJ cord-023095-4dannjjm 2802 20 for for IN cord-023095-4dannjjm 2802 21 EPI EPI NNP cord-023095-4dannjjm 2802 22 in in IN cord-023095-4dannjjm 2802 23 the the DT cord-023095-4dannjjm 2802 24 dogs dog NNS cord-023095-4dannjjm 2802 25 with with IN cord-023095-4dannjjm 2802 26 a a DT cord-023095-4dannjjm 2802 27 decreased decrease VBN cord-023095-4dannjjm 2802 28 serum serum NN cord-023095-4dannjjm 2802 29 cobalamin cobalamin NN cord-023095-4dannjjm 2802 30 concentration concentration NN cord-023095-4dannjjm 2802 31 . . . cord-023095-4dannjjm 2803 1 Except except IN cord-023095-4dannjjm 2803 2 for for IN cord-023095-4dannjjm 2803 3 CSP CSP NNP cord-023095-4dannjjm 2803 4 , , , cord-023095-4dannjjm 2803 5 breeds breed NNS cord-023095-4dannjjm 2803 6 identified identify VBN cord-023095-4dannjjm 2803 7 here here RB cord-023095-4dannjjm 2803 8 , , , cord-023095-4dannjjm 2803 9 have have VBP cord-023095-4dannjjm 2803 10 not not RB cord-023095-4dannjjm 2803 11 previously previously RB cord-023095-4dannjjm 2803 12 been be VBN cord-023095-4dannjjm 2803 13 identified identify VBN cord-023095-4dannjjm 2803 14 to to TO cord-023095-4dannjjm 2803 15 have have VB cord-023095-4dannjjm 2803 16 a a DT cord-023095-4dannjjm 2803 17 higher high JJR cord-023095-4dannjjm 2803 18 rate rate NN cord-023095-4dannjjm 2803 19 of of IN cord-023095-4dannjjm 2803 20 a a DT cord-023095-4dannjjm 2803 21 decreased decrease VBN cord-023095-4dannjjm 2803 22 serum serum NN cord-023095-4dannjjm 2803 23 cobalamin cobalamin NN cord-023095-4dannjjm 2803 24 concentration concentration NN cord-023095-4dannjjm 2803 25 . . . cord-023095-4dannjjm 2804 1 Also also RB cord-023095-4dannjjm 2804 2 , , , cord-023095-4dannjjm 2804 3 a a DT cord-023095-4dannjjm 2804 4 possible possible JJ cord-023095-4dannjjm 2804 5 association association NN cord-023095-4dannjjm 2804 6 between between IN cord-023095-4dannjjm 2804 7 an an DT cord-023095-4dannjjm 2804 8 undetectable undetectable JJ cord-023095-4dannjjm 2804 9 serum serum NN cord-023095-4dannjjm 2804 10 cobalamin cobalamin NN cord-023095-4dannjjm 2804 11 and and CC cord-023095-4dannjjm 2804 12 a a DT cord-023095-4dannjjm 2804 13 decreased decrease VBN cord-023095-4dannjjm 2804 14 serum serum NN cord-023095-4dannjjm 2804 15 TLI TLI NNP cord-023095-4dannjjm 2804 16 in in IN cord-023095-4dannjjm 2804 17 AI AI NNP cord-023095-4dannjjm 2804 18 needs need VBZ cord-023095-4dannjjm 2804 19 to to TO cord-023095-4dannjjm 2804 20 be be VB cord-023095-4dannjjm 2804 21 further further RB cord-023095-4dannjjm 2804 22 investigated investigate VBN cord-023095-4dannjjm 2804 23 . . . cord-023095-4dannjjm 2805 1 Calprotectin Calprotectin NNP cord-023095-4dannjjm 2805 2 ( ( -LRB- cord-023095-4dannjjm 2805 3 CP CP NNP cord-023095-4dannjjm 2805 4 ) ) -RRB- cord-023095-4dannjjm 2805 5 is be VBZ cord-023095-4dannjjm 2805 6 a a DT cord-023095-4dannjjm 2805 7 widely widely RB cord-023095-4dannjjm 2805 8 used use VBN cord-023095-4dannjjm 2805 9 marker marker NN cord-023095-4dannjjm 2805 10 for for IN cord-023095-4dannjjm 2805 11 the the DT cord-023095-4dannjjm 2805 12 diagnosis diagnosis NN cord-023095-4dannjjm 2805 13 and and CC cord-023095-4dannjjm 2805 14 monitoring monitoring NN cord-023095-4dannjjm 2805 15 of of IN cord-023095-4dannjjm 2805 16 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2805 17 ( ( -LRB- cord-023095-4dannjjm 2805 18 GI gi NN cord-023095-4dannjjm 2805 19 ) ) -RRB- cord-023095-4dannjjm 2805 20 inflammation inflammation NN cord-023095-4dannjjm 2805 21 in in IN cord-023095-4dannjjm 2805 22 humans human NNS cord-023095-4dannjjm 2805 23 . . . cord-023095-4dannjjm 2806 1 Studies study NNS cord-023095-4dannjjm 2806 2 in in IN cord-023095-4dannjjm 2806 3 humans human NNS cord-023095-4dannjjm 2806 4 usually usually RB cord-023095-4dannjjm 2806 5 report report VBP cord-023095-4dannjjm 2806 6 fecal fecal JJ cord-023095-4dannjjm 2806 7 CP cp NN cord-023095-4dannjjm 2806 8 concentrations concentration NNS cord-023095-4dannjjm 2806 9 based base VBN cord-023095-4dannjjm 2806 10 on on IN cord-023095-4dannjjm 2806 11 a a DT cord-023095-4dannjjm 2806 12 single single JJ cord-023095-4dannjjm 2806 13 stool stool NN cord-023095-4dannjjm 2806 14 sample sample NN cord-023095-4dannjjm 2806 15 although although IN cord-023095-4dannjjm 2806 16 considerable considerable JJ cord-023095-4dannjjm 2806 17 day day NN cord-023095-4dannjjm 2806 18 - - HYPH cord-023095-4dannjjm 2806 19 to to IN cord-023095-4dannjjm 2806 20 - - HYPH cord-023095-4dannjjm 2806 21 day day NN cord-023095-4dannjjm 2806 22 variability variability NN cord-023095-4dannjjm 2806 23 of of IN cord-023095-4dannjjm 2806 24 fecal fecal JJ cord-023095-4dannjjm 2806 25 CP CP NNP cord-023095-4dannjjm 2806 26 was be VBD cord-023095-4dannjjm 2806 27 found find VBN cord-023095-4dannjjm 2806 28 in in IN cord-023095-4dannjjm 2806 29 patients patient NNS cord-023095-4dannjjm 2806 30 with with IN cord-023095-4dannjjm 2806 31 GI GI NNP cord-023095-4dannjjm 2806 32 disease disease NN cord-023095-4dannjjm 2806 33 and and CC cord-023095-4dannjjm 2806 34 in in IN cord-023095-4dannjjm 2806 35 healthy healthy JJ cord-023095-4dannjjm 2806 36 controls control NNS cord-023095-4dannjjm 2806 37 . . . cord-023095-4dannjjm 2807 1 Intra intra JJ cord-023095-4dannjjm 2807 2 - - JJ cord-023095-4dannjjm 2807 3 individual individual JJ cord-023095-4dannjjm 2807 4 variation variation NN cord-023095-4dannjjm 2807 5 of of IN cord-023095-4dannjjm 2807 6 canine canine JJ cord-023095-4dannjjm 2807 7 CP cp NN cord-023095-4dannjjm 2807 8 ( ( -LRB- cord-023095-4dannjjm 2807 9 cCP cCP NNP cord-023095-4dannjjm 2807 10 ) ) -RRB- cord-023095-4dannjjm 2807 11 was be VBD cord-023095-4dannjjm 2807 12 also also RB cord-023095-4dannjjm 2807 13 substantial substantial JJ cord-023095-4dannjjm 2807 14 in in IN cord-023095-4dannjjm 2807 15 a a DT cord-023095-4dannjjm 2807 16 small small JJ cord-023095-4dannjjm 2807 17 number number NN cord-023095-4dannjjm 2807 18 of of IN cord-023095-4dannjjm 2807 19 healthy healthy JJ cord-023095-4dannjjm 2807 20 dogs dog NNS cord-023095-4dannjjm 2807 21 but but CC cord-023095-4dannjjm 2807 22 has have VBZ cord-023095-4dannjjm 2807 23 not not RB cord-023095-4dannjjm 2807 24 been be VBN cord-023095-4dannjjm 2807 25 determined determine VBN cord-023095-4dannjjm 2807 26 in in IN cord-023095-4dannjjm 2807 27 dogs dog NNS cord-023095-4dannjjm 2807 28 with with IN cord-023095-4dannjjm 2807 29 chronic chronic JJ cord-023095-4dannjjm 2807 30 GI GI NNP cord-023095-4dannjjm 2807 31 disease disease NN cord-023095-4dannjjm 2807 32 . . . cord-023095-4dannjjm 2808 1 Thus thus RB cord-023095-4dannjjm 2808 2 , , , cord-023095-4dannjjm 2808 3 the the DT cord-023095-4dannjjm 2808 4 aim aim NN cord-023095-4dannjjm 2808 5 of of IN cord-023095-4dannjjm 2808 6 this this DT cord-023095-4dannjjm 2808 7 study study NN cord-023095-4dannjjm 2808 8 was be VBD cord-023095-4dannjjm 2808 9 to to TO cord-023095-4dannjjm 2808 10 compare compare VB cord-023095-4dannjjm 2808 11 the the DT cord-023095-4dannjjm 2808 12 day day NN cord-023095-4dannjjm 2808 13 - - HYPH cord-023095-4dannjjm 2808 14 to to IN cord-023095-4dannjjm 2808 15 - - HYPH cord-023095-4dannjjm 2808 16 day day NN cord-023095-4dannjjm 2808 17 variation variation NN cord-023095-4dannjjm 2808 18 of of IN cord-023095-4dannjjm 2808 19 fecal fecal NN cord-023095-4dannjjm 2808 20 cCP ccp RB cord-023095-4dannjjm 2808 21 in in IN cord-023095-4dannjjm 2808 22 dogs dog NNS cord-023095-4dannjjm 2808 23 with with IN cord-023095-4dannjjm 2808 24 chronic chronic JJ cord-023095-4dannjjm 2808 25 GI GI NNP cord-023095-4dannjjm 2808 26 disease disease NN cord-023095-4dannjjm 2808 27 before before IN cord-023095-4dannjjm 2808 28 and and CC cord-023095-4dannjjm 2808 29 during during IN cord-023095-4dannjjm 2808 30 treatment treatment NN cord-023095-4dannjjm 2808 31 to to IN cord-023095-4dannjjm 2808 32 that that DT cord-023095-4dannjjm 2808 33 in in IN cord-023095-4dannjjm 2808 34 healthy healthy JJ cord-023095-4dannjjm 2808 35 dogs dog NNS cord-023095-4dannjjm 2808 36 . . . cord-023095-4dannjjm 2809 1 We -PRON- PRP cord-023095-4dannjjm 2809 2 hypothesized hypothesize VBD cord-023095-4dannjjm 2809 3 that that IN cord-023095-4dannjjm 2809 4 fecal fecal NN cord-023095-4dannjjm 2809 5 cCP ccp CD cord-023095-4dannjjm 2809 6 would would MD cord-023095-4dannjjm 2809 7 be be VB cord-023095-4dannjjm 2809 8 less less RBR cord-023095-4dannjjm 2809 9 variable variable JJ cord-023095-4dannjjm 2809 10 in in IN cord-023095-4dannjjm 2809 11 patients patient NNS cord-023095-4dannjjm 2809 12 with with IN cord-023095-4dannjjm 2809 13 chronic chronic JJ cord-023095-4dannjjm 2809 14 GI GI NNP cord-023095-4dannjjm 2809 15 disease disease NN cord-023095-4dannjjm 2809 16 than than IN cord-023095-4dannjjm 2809 17 in in IN cord-023095-4dannjjm 2809 18 healthy healthy JJ cord-023095-4dannjjm 2809 19 controls control NNS cord-023095-4dannjjm 2809 20 , , , cord-023095-4dannjjm 2809 21 and and CC cord-023095-4dannjjm 2809 22 thus thus RB cord-023095-4dannjjm 2809 23 collection collection NN cord-023095-4dannjjm 2809 24 of of IN cord-023095-4dannjjm 2809 25 a a DT cord-023095-4dannjjm 2809 26 single single JJ cord-023095-4dannjjm 2809 27 fecal fecal JJ cord-023095-4dannjjm 2809 28 sample sample NN cord-023095-4dannjjm 2809 29 would would MD cord-023095-4dannjjm 2809 30 be be VB cord-023095-4dannjjm 2809 31 sufficient sufficient JJ cord-023095-4dannjjm 2809 32 . . . cord-023095-4dannjjm 2810 1 Fecal fecal JJ cord-023095-4dannjjm 2810 2 samples sample NNS cord-023095-4dannjjm 2810 3 from from IN cord-023095-4dannjjm 2810 4 3 3 CD cord-023095-4dannjjm 2810 5 consecutive consecutive JJ cord-023095-4dannjjm 2810 6 days day NNS cord-023095-4dannjjm 2810 7 were be VBD cord-023095-4dannjjm 2810 8 prospectively prospectively RB cord-023095-4dannjjm 2810 9 collected collect VBN cord-023095-4dannjjm 2810 10 from from IN cord-023095-4dannjjm 2810 11 15 15 CD cord-023095-4dannjjm 2810 12 dogs dog NNS cord-023095-4dannjjm 2810 13 ( ( -LRB- cord-023095-4dannjjm 2810 14 group group NN cord-023095-4dannjjm 2810 15 A a NN cord-023095-4dannjjm 2810 16 ; ; : cord-023095-4dannjjm 2810 17 median median JJ cord-023095-4dannjjm 2810 18 age age NN cord-023095-4dannjjm 2810 19 : : : cord-023095-4dannjjm 2810 20 6.1 6.1 CD cord-023095-4dannjjm 2810 21 years year NNS cord-023095-4dannjjm 2810 22 ) ) -RRB- cord-023095-4dannjjm 2810 23 referred refer VBD cord-023095-4dannjjm 2810 24 for for IN cord-023095-4dannjjm 2810 25 diagnostic diagnostic JJ cord-023095-4dannjjm 2810 26 work work NN cord-023095-4dannjjm 2810 27 - - HYPH cord-023095-4dannjjm 2810 28 up up NN cord-023095-4dannjjm 2810 29 of of IN cord-023095-4dannjjm 2810 30 chronic chronic JJ cord-023095-4dannjjm 2810 31 signs sign NNS cord-023095-4dannjjm 2810 32 of of IN cord-023095-4dannjjm 2810 33 GI GI NNP cord-023095-4dannjjm 2810 34 disease disease NN cord-023095-4dannjjm 2810 35 , , , cord-023095-4dannjjm 2810 36 from from IN cord-023095-4dannjjm 2810 37 8 8 CD cord-023095-4dannjjm 2810 38 dogs dog NNS cord-023095-4dannjjm 2810 39 ( ( -LRB- cord-023095-4dannjjm 2810 40 group group NN cord-023095-4dannjjm 2810 41 B b NN cord-023095-4dannjjm 2810 42 ; ; : cord-023095-4dannjjm 2810 43 median median JJ cord-023095-4dannjjm 2810 44 age age NN cord-023095-4dannjjm 2810 45 : : : cord-023095-4dannjjm 2810 46 5.6 5.6 CD cord-023095-4dannjjm 2810 47 years year NNS cord-023095-4dannjjm 2810 48 ) ) -RRB- cord-023095-4dannjjm 2810 49 with with IN cord-023095-4dannjjm 2810 50 stable stable JJ cord-023095-4dannjjm 2810 51 GI GI NNP cord-023095-4dannjjm 2810 52 disease disease NN cord-023095-4dannjjm 2810 53 while while IN cord-023095-4dannjjm 2810 54 being be VBG cord-023095-4dannjjm 2810 55 treated treat VBN cord-023095-4dannjjm 2810 56 , , , cord-023095-4dannjjm 2810 57 and and CC cord-023095-4dannjjm 2810 58 from from IN cord-023095-4dannjjm 2810 59 44 44 CD cord-023095-4dannjjm 2810 60 healthy healthy JJ cord-023095-4dannjjm 2810 61 adult adult NN cord-023095-4dannjjm 2810 62 dogs dog NNS cord-023095-4dannjjm 2810 63 ( ( -LRB- cord-023095-4dannjjm 2810 64 group group NN cord-023095-4dannjjm 2810 65 C C NNP cord-023095-4dannjjm 2810 66 ; ; : cord-023095-4dannjjm 2810 67 mean mean VB cord-023095-4dannjjm 2810 68 age age NN cord-023095-4dannjjm 2810 69 : : : cord-023095-4dannjjm 2810 70 5.4 5.4 CD cord-023095-4dannjjm 2810 71 years year NNS cord-023095-4dannjjm 2810 72 ) ) -RRB- cord-023095-4dannjjm 2810 73 . . . cord-023095-4dannjjm 2811 1 Fecal fecal JJ cord-023095-4dannjjm 2811 2 samples sample NNS cord-023095-4dannjjm 2811 3 were be VBD cord-023095-4dannjjm 2811 4 extracted extract VBN cord-023095-4dannjjm 2811 5 and and CC cord-023095-4dannjjm 2811 6 cCP cCP NNP cord-023095-4dannjjm 2811 7 was be VBD cord-023095-4dannjjm 2811 8 measured measure VBN cord-023095-4dannjjm 2811 9 by by IN cord-023095-4dannjjm 2811 10 an an DT cord-023095-4dannjjm 2811 11 in in IN cord-023095-4dannjjm 2811 12 - - HYPH cord-023095-4dannjjm 2811 13 house house NN cord-023095-4dannjjm 2811 14 immunoassay immunoassay NN cord-023095-4dannjjm 2811 15 . . . cord-023095-4dannjjm 2812 1 Mean mean JJ cord-023095-4dannjjm 2812 2 cCP ccp RB cord-023095-4dannjjm 2812 3 , , , cord-023095-4dannjjm 2812 4 standard standard JJ cord-023095-4dannjjm 2812 5 deviation deviation NN cord-023095-4dannjjm 2812 6 , , , cord-023095-4dannjjm 2812 7 coefficient coefficient NN cord-023095-4dannjjm 2812 8 of of IN cord-023095-4dannjjm 2812 9 variation variation NN cord-023095-4dannjjm 2812 10 ( ( -LRB- cord-023095-4dannjjm 2812 11 CV CV NNP cord-023095-4dannjjm 2812 12 ) ) -RRB- cord-023095-4dannjjm 2812 13 , , , cord-023095-4dannjjm 2812 14 and and CC cord-023095-4dannjjm 2812 15 difference difference NN cord-023095-4dannjjm 2812 16 between between IN cord-023095-4dannjjm 2812 17 maximum maximum NN cord-023095-4dannjjm 2812 18 and and CC cord-023095-4dannjjm 2812 19 minimum minimum NN cord-023095-4dannjjm 2812 20 cCP ccp RB cord-023095-4dannjjm 2812 21 for for IN cord-023095-4dannjjm 2812 22 the the DT cord-023095-4dannjjm 2812 23 3-day 3-day JJ cord-023095-4dannjjm 2812 24 sample sample NN cord-023095-4dannjjm 2812 25 collection collection NN cord-023095-4dannjjm 2812 26 period period NN cord-023095-4dannjjm 2812 27 were be VBD cord-023095-4dannjjm 2812 28 calculated calculate VBN cord-023095-4dannjjm 2812 29 for for IN cord-023095-4dannjjm 2812 30 each each DT cord-023095-4dannjjm 2812 31 dog dog NN cord-023095-4dannjjm 2812 32 and and CC cord-023095-4dannjjm 2812 33 were be VBD cord-023095-4dannjjm 2812 34 compared compare VBN cord-023095-4dannjjm 2812 35 among among IN cord-023095-4dannjjm 2812 36 groups group NNS cord-023095-4dannjjm 2812 37 using use VBG cord-023095-4dannjjm 2812 38 a a DT cord-023095-4dannjjm 2812 39 Kruskal Kruskal NNP cord-023095-4dannjjm 2812 40 - - HYPH cord-023095-4dannjjm 2812 41 Wallis Wallis NNP cord-023095-4dannjjm 2812 42 test test NN cord-023095-4dannjjm 2812 43 . . . cord-023095-4dannjjm 2813 1 Fecal fecal NN cord-023095-4dannjjm 2813 2 cCP cCP NNP cord-023095-4dannjjm 2813 3 ranged range VBD cord-023095-4dannjjm 2813 4 from from IN cord-023095-4dannjjm 2813 5 2.9 2.9 CD cord-023095-4dannjjm 2813 6 - - SYM cord-023095-4dannjjm 2813 7 102.7 102.7 CD cord-023095-4dannjjm 2813 8 mg mg NNP cord-023095-4dannjjm 2813 9 / / SYM cord-023095-4dannjjm 2813 10 g g NNP cord-023095-4dannjjm 2813 11 ( ( -LRB- cord-023095-4dannjjm 2813 12 median median NN cord-023095-4dannjjm 2813 13 : : : cord-023095-4dannjjm 2813 14 17.6 17.6 CD cord-023095-4dannjjm 2813 15 mg mg NNP cord-023095-4dannjjm 2813 16 / / SYM cord-023095-4dannjjm 2813 17 g g NNP cord-023095-4dannjjm 2813 18 ) ) -RRB- cord-023095-4dannjjm 2813 19 in in IN cord-023095-4dannjjm 2813 20 dogs dog NNS cord-023095-4dannjjm 2813 21 with with IN cord-023095-4dannjjm 2813 22 GI GI NNP cord-023095-4dannjjm 2813 23 disease disease NN cord-023095-4dannjjm 2813 24 ( ( -LRB- cord-023095-4dannjjm 2813 25 group group NN cord-023095-4dannjjm 2813 26 A A NNP cord-023095-4dannjjm 2813 27 ) ) -RRB- cord-023095-4dannjjm 2813 28 , , , cord-023095-4dannjjm 2813 29 from from IN cord-023095-4dannjjm 2813 30 2.9 2.9 CD cord-023095-4dannjjm 2813 31 - - SYM cord-023095-4dannjjm 2813 32 265.1 265.1 CD cord-023095-4dannjjm 2813 33 mg mg NNP cord-023095-4dannjjm 2813 34 / / SYM cord-023095-4dannjjm 2813 35 g g NNP cord-023095-4dannjjm 2813 36 ( ( -LRB- cord-023095-4dannjjm 2813 37 median median NN cord-023095-4dannjjm 2813 38 : : : cord-023095-4dannjjm 2813 39 18.4 18.4 CD cord-023095-4dannjjm 2813 40 mg mg NNP cord-023095-4dannjjm 2813 41 / / SYM cord-023095-4dannjjm 2813 42 g g NNP cord-023095-4dannjjm 2813 43 ) ) -RRB- cord-023095-4dannjjm 2813 44 in in IN cord-023095-4dannjjm 2813 45 dogs dog NNS cord-023095-4dannjjm 2813 46 of of IN cord-023095-4dannjjm 2813 47 group group NN cord-023095-4dannjjm 2813 48 B B NNP cord-023095-4dannjjm 2813 49 , , , cord-023095-4dannjjm 2813 50 and and CC cord-023095-4dannjjm 2813 51 from from IN cord-023095-4dannjjm 2813 52 2.9 2.9 CD cord-023095-4dannjjm 2813 53 - - HYPH cord-023095-4dannjjm 2813 54 93.1 93.1 CD cord-023095-4dannjjm 2813 55 mg mg NNP cord-023095-4dannjjm 2813 56 / / SYM cord-023095-4dannjjm 2813 57 g g NNP cord-023095-4dannjjm 2813 58 ( ( -LRB- cord-023095-4dannjjm 2813 59 median median NN cord-023095-4dannjjm 2813 60 : : : cord-023095-4dannjjm 2813 61 7.9 7.9 CD cord-023095-4dannjjm 2813 62 mg mg NNP cord-023095-4dannjjm 2813 63 / / SYM cord-023095-4dannjjm 2813 64 g g NN cord-023095-4dannjjm 2813 65 ) ) -RRB- cord-023095-4dannjjm 2813 66 in in IN cord-023095-4dannjjm 2813 67 healthy healthy JJ cord-023095-4dannjjm 2813 68 controls control NNS cord-023095-4dannjjm 2813 69 ( ( -LRB- cord-023095-4dannjjm 2813 70 group group NN cord-023095-4dannjjm 2813 71 C C NNP cord-023095-4dannjjm 2813 72 ) ) -RRB- cord-023095-4dannjjm 2813 73 . . . cord-023095-4dannjjm 2814 1 CVs cv NNS cord-023095-4dannjjm 2814 2 were be VBD cord-023095-4dannjjm 2814 3 0 0 CD cord-023095-4dannjjm 2814 4 - - SYM cord-023095-4dannjjm 2814 5 121.3 121.3 CD cord-023095-4dannjjm 2814 6 % % NN cord-023095-4dannjjm 2814 7 in in IN cord-023095-4dannjjm 2814 8 group group NN cord-023095-4dannjjm 2814 9 A a NN cord-023095-4dannjjm 2814 10 ( ( -LRB- cord-023095-4dannjjm 2814 11 median median NN cord-023095-4dannjjm 2814 12 : : : cord-023095-4dannjjm 2814 13 20.0 20.0 CD cord-023095-4dannjjm 2814 14 % % NN cord-023095-4dannjjm 2814 15 ) ) -RRB- cord-023095-4dannjjm 2814 16 , , , cord-023095-4dannjjm 2814 17 2.0 2.0 CD cord-023095-4dannjjm 2814 18 - - HYPH cord-023095-4dannjjm 2814 19 89.4 89.4 CD cord-023095-4dannjjm 2814 20 % % NN cord-023095-4dannjjm 2814 21 in in IN cord-023095-4dannjjm 2814 22 group group NN cord-023095-4dannjjm 2814 23 B b NN cord-023095-4dannjjm 2814 24 ( ( -LRB- cord-023095-4dannjjm 2814 25 median median NN cord-023095-4dannjjm 2814 26 : : : cord-023095-4dannjjm 2814 27 47.4 47.4 CD cord-023095-4dannjjm 2814 28 % % NN cord-023095-4dannjjm 2814 29 ) ) -RRB- cord-023095-4dannjjm 2814 30 , , , cord-023095-4dannjjm 2814 31 and and CC cord-023095-4dannjjm 2814 32 0 0 CD cord-023095-4dannjjm 2814 33 - - SYM cord-023095-4dannjjm 2814 34 145.2 145.2 CD cord-023095-4dannjjm 2814 35 % % NN cord-023095-4dannjjm 2814 36 in in IN cord-023095-4dannjjm 2814 37 group group NN cord-023095-4dannjjm 2814 38 C C NNP cord-023095-4dannjjm 2814 39 ( ( -LRB- cord-023095-4dannjjm 2814 40 median median NN cord-023095-4dannjjm 2814 41 : : : cord-023095-4dannjjm 2814 42 40.4 40.4 CD cord-023095-4dannjjm 2814 43 % % NN cord-023095-4dannjjm 2814 44 ) ) -RRB- cord-023095-4dannjjm 2814 45 , , , cord-023095-4dannjjm 2814 46 respectively respectively RB cord-023095-4dannjjm 2814 47 . . . cord-023095-4dannjjm 2815 1 Patients patient NNS cord-023095-4dannjjm 2815 2 in in IN cord-023095-4dannjjm 2815 3 group group NN cord-023095-4dannjjm 2815 4 A A NNP cord-023095-4dannjjm 2815 5 appeared appear VBD cord-023095-4dannjjm 2815 6 to to TO cord-023095-4dannjjm 2815 7 have have VB cord-023095-4dannjjm 2815 8 less less JJR cord-023095-4dannjjm 2815 9 variable variable JJ cord-023095-4dannjjm 2815 10 fecal fecal NN cord-023095-4dannjjm 2815 11 cCP ccp RB cord-023095-4dannjjm 2815 12 than than IN cord-023095-4dannjjm 2815 13 dogs dog NNS cord-023095-4dannjjm 2815 14 in in IN cord-023095-4dannjjm 2815 15 group group NN cord-023095-4dannjjm 2815 16 B B NNP cord-023095-4dannjjm 2815 17 and and CC cord-023095-4dannjjm 2815 18 C C NNP cord-023095-4dannjjm 2815 19 , , , cord-023095-4dannjjm 2815 20 but but CC cord-023095-4dannjjm 2815 21 this this DT cord-023095-4dannjjm 2815 22 difference difference NN cord-023095-4dannjjm 2815 23 was be VBD cord-023095-4dannjjm 2815 24 not not RB cord-023095-4dannjjm 2815 25 significant significant JJ cord-023095-4dannjjm 2816 1 ( ( -LRB- cord-023095-4dannjjm 2816 2 p p NN cord-023095-4dannjjm 2816 3 5 5 CD cord-023095-4dannjjm 2816 4 0.326 0.326 CD cord-023095-4dannjjm 2816 5 ) ) -RRB- cord-023095-4dannjjm 2816 6 . . . cord-023095-4dannjjm 2817 1 The the DT cord-023095-4dannjjm 2817 2 difference difference NN cord-023095-4dannjjm 2817 3 between between IN cord-023095-4dannjjm 2817 4 maximum maximum NN cord-023095-4dannjjm 2817 5 and and CC cord-023095-4dannjjm 2817 6 minimum minimum NN cord-023095-4dannjjm 2817 7 cCP ccp RB cord-023095-4dannjjm 2817 8 for for IN cord-023095-4dannjjm 2817 9 the the DT cord-023095-4dannjjm 2817 10 3-day 3-day JJ cord-023095-4dannjjm 2817 11 sample sample NN cord-023095-4dannjjm 2817 12 collection collection NN cord-023095-4dannjjm 2817 13 ranged range VBD cord-023095-4dannjjm 2817 14 from from IN cord-023095-4dannjjm 2817 15 0 0 CD cord-023095-4dannjjm 2817 16 - - SYM cord-023095-4dannjjm 2817 17 31.1 31.1 CD cord-023095-4dannjjm 2817 18 mg mg NNP cord-023095-4dannjjm 2817 19 / / SYM cord-023095-4dannjjm 2817 20 g g NN cord-023095-4dannjjm 2817 21 in in IN cord-023095-4dannjjm 2817 22 group group NN cord-023095-4dannjjm 2817 23 A A NNP cord-023095-4dannjjm 2817 24 ( ( -LRB- cord-023095-4dannjjm 2817 25 median median NN cord-023095-4dannjjm 2817 26 : : : cord-023095-4dannjjm 2817 27 7.2 7.2 CD cord-023095-4dannjjm 2817 28 mg mg NNP cord-023095-4dannjjm 2817 29 / / SYM cord-023095-4dannjjm 2817 30 g g NNP cord-023095-4dannjjm 2817 31 ) ) -RRB- cord-023095-4dannjjm 2817 32 , , , cord-023095-4dannjjm 2817 33 from from IN cord-023095-4dannjjm 2817 34 0.1 0.1 CD cord-023095-4dannjjm 2817 35 - - SYM cord-023095-4dannjjm 2817 36 240.0 240.0 CD cord-023095-4dannjjm 2817 37 mg mg NNP cord-023095-4dannjjm 2817 38 / / SYM cord-023095-4dannjjm 2817 39 g g NN cord-023095-4dannjjm 2817 40 in in IN cord-023095-4dannjjm 2817 41 group group NN cord-023095-4dannjjm 2817 42 B b NN cord-023095-4dannjjm 2817 43 ( ( -LRB- cord-023095-4dannjjm 2817 44 median median NN cord-023095-4dannjjm 2817 45 : : : cord-023095-4dannjjm 2817 46 12.5 12.5 CD cord-023095-4dannjjm 2817 47 mg mg NNP cord-023095-4dannjjm 2817 48 / / SYM cord-023095-4dannjjm 2817 49 g g NNP cord-023095-4dannjjm 2817 50 ) ) -RRB- cord-023095-4dannjjm 2817 51 , , , cord-023095-4dannjjm 2817 52 and and CC cord-023095-4dannjjm 2817 53 from from IN cord-023095-4dannjjm 2817 54 0 0 CD cord-023095-4dannjjm 2817 55 - - HYPH cord-023095-4dannjjm 2817 56 57.4 57.4 CD cord-023095-4dannjjm 2817 57 mg mg NNP cord-023095-4dannjjm 2817 58 / / SYM cord-023095-4dannjjm 2817 59 g g NN cord-023095-4dannjjm 2817 60 in in IN cord-023095-4dannjjm 2817 61 group group NN cord-023095-4dannjjm 2817 62 C C NNP cord-023095-4dannjjm 2817 63 ( ( -LRB- cord-023095-4dannjjm 2817 64 median median NN cord-023095-4dannjjm 2817 65 : : : cord-023095-4dannjjm 2817 66 14.8 14.8 CD cord-023095-4dannjjm 2817 67 mg mg NNP cord-023095-4dannjjm 2817 68 / / SYM cord-023095-4dannjjm 2817 69 g g NNP cord-023095-4dannjjm 2817 70 ) ) -RRB- cord-023095-4dannjjm 2817 71 , , , cord-023095-4dannjjm 2817 72 and and CC cord-023095-4dannjjm 2817 73 were be VBD cord-023095-4dannjjm 2817 74 not not RB cord-023095-4dannjjm 2817 75 significantly significantly RB cord-023095-4dannjjm 2817 76 different different JJ cord-023095-4dannjjm 2817 77 between between IN cord-023095-4dannjjm 2817 78 any any DT cord-023095-4dannjjm 2817 79 of of IN cord-023095-4dannjjm 2817 80 the the DT cord-023095-4dannjjm 2817 81 groups group NNS cord-023095-4dannjjm 2817 82 ( ( -LRB- cord-023095-4dannjjm 2817 83 p p NN cord-023095-4dannjjm 2817 84 5 5 CD cord-023095-4dannjjm 2817 85 0.530 0.530 CD cord-023095-4dannjjm 2817 86 ) ) -RRB- cord-023095-4dannjjm 2817 87 . . . cord-023095-4dannjjm 2818 1 In in IN cord-023095-4dannjjm 2818 2 this this DT cord-023095-4dannjjm 2818 3 study study NN cord-023095-4dannjjm 2818 4 , , , cord-023095-4dannjjm 2818 5 considerable considerable JJ cord-023095-4dannjjm 2818 6 day day NN cord-023095-4dannjjm 2818 7 - - HYPH cord-023095-4dannjjm 2818 8 to to IN cord-023095-4dannjjm 2818 9 - - HYPH cord-023095-4dannjjm 2818 10 day day NN cord-023095-4dannjjm 2818 11 variation variation NN cord-023095-4dannjjm 2818 12 of of IN cord-023095-4dannjjm 2818 13 fecal fecal NN cord-023095-4dannjjm 2818 14 cCP cCP NNP cord-023095-4dannjjm 2818 15 was be VBD cord-023095-4dannjjm 2818 16 found find VBN cord-023095-4dannjjm 2818 17 in in IN cord-023095-4dannjjm 2818 18 dogs dog NNS cord-023095-4dannjjm 2818 19 with with IN cord-023095-4dannjjm 2818 20 chronic chronic JJ cord-023095-4dannjjm 2818 21 GI gi NN cord-023095-4dannjjm 2818 22 disease disease NN cord-023095-4dannjjm 2818 23 ( ( -LRB- cord-023095-4dannjjm 2818 24 regardless regardless RB cord-023095-4dannjjm 2818 25 of of IN cord-023095-4dannjjm 2818 26 treatment treatment NN cord-023095-4dannjjm 2818 27 ) ) -RRB- cord-023095-4dannjjm 2818 28 and and CC cord-023095-4dannjjm 2818 29 was be VBD cord-023095-4dannjjm 2818 30 comparable comparable JJ cord-023095-4dannjjm 2818 31 to to IN cord-023095-4dannjjm 2818 32 that that DT cord-023095-4dannjjm 2818 33 in in IN cord-023095-4dannjjm 2818 34 healthy healthy JJ cord-023095-4dannjjm 2818 35 dogs dog NNS cord-023095-4dannjjm 2818 36 . . . cord-023095-4dannjjm 2819 1 Results result NNS cord-023095-4dannjjm 2819 2 of of IN cord-023095-4dannjjm 2819 3 this this DT cord-023095-4dannjjm 2819 4 study study NN cord-023095-4dannjjm 2819 5 suggest suggest VBP cord-023095-4dannjjm 2819 6 that that IN cord-023095-4dannjjm 2819 7 for for IN cord-023095-4dannjjm 2819 8 evaluating evaluate VBG cord-023095-4dannjjm 2819 9 fecal fecal NN cord-023095-4dannjjm 2819 10 cCP ccp RB cord-023095-4dannjjm 2819 11 in in IN cord-023095-4dannjjm 2819 12 dogs dog NNS cord-023095-4dannjjm 2819 13 with with IN cord-023095-4dannjjm 2819 14 clinical clinical JJ cord-023095-4dannjjm 2819 15 signs sign NNS cord-023095-4dannjjm 2819 16 of of IN cord-023095-4dannjjm 2819 17 GI GI NNP cord-023095-4dannjjm 2819 18 disease disease NN cord-023095-4dannjjm 2819 19 , , , cord-023095-4dannjjm 2819 20 three three CD cord-023095-4dannjjm 2819 21 consecutive consecutive JJ cord-023095-4dannjjm 2819 22 fecal fecal JJ cord-023095-4dannjjm 2819 23 samples sample NNS cord-023095-4dannjjm 2819 24 rather rather RB cord-023095-4dannjjm 2819 25 than than IN cord-023095-4dannjjm 2819 26 a a DT cord-023095-4dannjjm 2819 27 single single JJ cord-023095-4dannjjm 2819 28 fecal fecal JJ cord-023095-4dannjjm 2819 29 sample sample NN cord-023095-4dannjjm 2819 30 should should MD cord-023095-4dannjjm 2819 31 be be VB cord-023095-4dannjjm 2819 32 analyzed analyze VBN cord-023095-4dannjjm 2819 33 . . . cord-023095-4dannjjm 2820 1 Because because IN cord-023095-4dannjjm 2820 2 we -PRON- PRP cord-023095-4dannjjm 2820 3 did do VBD cord-023095-4dannjjm 2820 4 not not RB cord-023095-4dannjjm 2820 5 intend intend VB cord-023095-4dannjjm 2820 6 to to TO cord-023095-4dannjjm 2820 7 evaluate evaluate VB cord-023095-4dannjjm 2820 8 the the DT cord-023095-4dannjjm 2820 9 clinical clinical JJ cord-023095-4dannjjm 2820 10 usefulness usefulness NN cord-023095-4dannjjm 2820 11 of of IN cord-023095-4dannjjm 2820 12 fecal fecal NN cord-023095-4dannjjm 2820 13 cCP ccp RB cord-023095-4dannjjm 2820 14 as as IN cord-023095-4dannjjm 2820 15 a a DT cord-023095-4dannjjm 2820 16 marker marker NN cord-023095-4dannjjm 2820 17 of of IN cord-023095-4dannjjm 2820 18 GI GI NNP cord-023095-4dannjjm 2820 19 disease disease NN cord-023095-4dannjjm 2820 20 in in IN cord-023095-4dannjjm 2820 21 dogs dog NNS cord-023095-4dannjjm 2820 22 , , , cord-023095-4dannjjm 2820 23 disease disease NN cord-023095-4dannjjm 2820 24 severity severity NN cord-023095-4dannjjm 2820 25 , , , cord-023095-4dannjjm 2820 26 quality quality NN cord-023095-4dannjjm 2820 27 , , , cord-023095-4dannjjm 2820 28 and and CC cord-023095-4dannjjm 2820 29 location location NN cord-023095-4dannjjm 2820 30 differed differ VBD cord-023095-4dannjjm 2820 31 among among IN cord-023095-4dannjjm 2820 32 dogs dog NNS cord-023095-4dannjjm 2820 33 in in IN cord-023095-4dannjjm 2820 34 groups group NNS cord-023095-4dannjjm 2821 1 A A NNP cord-023095-4dannjjm 2821 2 and and CC cord-023095-4dannjjm 2821 3 B. B. NNP cord-023095-4dannjjm 2822 1 The the DT cord-023095-4dannjjm 2822 2 diagnostic diagnostic JJ cord-023095-4dannjjm 2822 3 utility utility NN cord-023095-4dannjjm 2822 4 of of IN cord-023095-4dannjjm 2822 5 fecal fecal NN cord-023095-4dannjjm 2822 6 cCP ccp RB cord-023095-4dannjjm 2822 7 in in IN cord-023095-4dannjjm 2822 8 dogs dog NNS cord-023095-4dannjjm 2822 9 with with IN cord-023095-4dannjjm 2822 10 GI GI NNP cord-023095-4dannjjm 2822 11 disease disease NN cord-023095-4dannjjm 2822 12 is be VBZ cord-023095-4dannjjm 2822 13 currently currently RB cord-023095-4dannjjm 2822 14 being be VBG cord-023095-4dannjjm 2822 15 investigated investigate VBN cord-023095-4dannjjm 2822 16 . . . cord-023095-4dannjjm 2823 1 It -PRON- PRP cord-023095-4dannjjm 2823 2 has have VBZ cord-023095-4dannjjm 2823 3 been be VBN cord-023095-4dannjjm 2823 4 suggested suggest VBN cord-023095-4dannjjm 2823 5 that that IN cord-023095-4dannjjm 2823 6 diagnosis diagnosis NN cord-023095-4dannjjm 2823 7 of of IN cord-023095-4dannjjm 2823 8 Clostridium clostridium NN cord-023095-4dannjjm 2823 9 perfringens perfringen NNS cord-023095-4dannjjm 2823 10 related relate VBN cord-023095-4dannjjm 2823 11 enteropathy enteropathy NNS cord-023095-4dannjjm 2823 12 should should MD cord-023095-4dannjjm 2823 13 be be VB cord-023095-4dannjjm 2823 14 based base VBN cord-023095-4dannjjm 2823 15 on on IN cord-023095-4dannjjm 2823 16 the the DT cord-023095-4dannjjm 2823 17 detection detection NN cord-023095-4dannjjm 2823 18 of of IN cord-023095-4dannjjm 2823 19 the the DT cord-023095-4dannjjm 2823 20 C. C. NNP cord-023095-4dannjjm 2823 21 perfringens perfringens NN cord-023095-4dannjjm 2823 22 enterotoxin enterotoxin NNP cord-023095-4dannjjm 2823 23 gene gene NNP cord-023095-4dannjjm 2823 24 ( ( -LRB- cord-023095-4dannjjm 2823 25 cpe cpe NNP cord-023095-4dannjjm 2823 26 - - HYPH cord-023095-4dannjjm 2823 27 gene gene NN cord-023095-4dannjjm 2823 28 ) ) -RRB- cord-023095-4dannjjm 2823 29 by by IN cord-023095-4dannjjm 2823 30 PCR PCR NNP cord-023095-4dannjjm 2823 31 and/or and/or CC cord-023095-4dannjjm 2823 32 C. C. NNP cord-023095-4dannjjm 2823 33 perfringens perfringens NN cord-023095-4dannjjm 2823 34 enterotoxin enterotoxin NNP cord-023095-4dannjjm 2823 35 ( ( -LRB- cord-023095-4dannjjm 2823 36 CPE CPE NNP cord-023095-4dannjjm 2823 37 ) ) -RRB- cord-023095-4dannjjm 2823 38 by by IN cord-023095-4dannjjm 2823 39 ELISA ELISA NNP cord-023095-4dannjjm 2823 40 in in IN cord-023095-4dannjjm 2823 41 feces fece NNS cord-023095-4dannjjm 2823 42 . . . cord-023095-4dannjjm 2824 1 However however RB cord-023095-4dannjjm 2824 2 , , , cord-023095-4dannjjm 2824 3 the the DT cord-023095-4dannjjm 2824 4 prevalence prevalence NN cord-023095-4dannjjm 2824 5 of of IN cord-023095-4dannjjm 2824 6 the the DT cord-023095-4dannjjm 2824 7 cpe cpe NNP cord-023095-4dannjjm 2824 8 - - HYPH cord-023095-4dannjjm 2824 9 gene gene NNP cord-023095-4dannjjm 2824 10 and and CC cord-023095-4dannjjm 2824 11 CPE CPE NNP cord-023095-4dannjjm 2824 12 in in IN cord-023095-4dannjjm 2824 13 dogs dog NNS cord-023095-4dannjjm 2824 14 and and CC cord-023095-4dannjjm 2824 15 especially especially RB cord-023095-4dannjjm 2824 16 cats cat NNS cord-023095-4dannjjm 2824 17 with with IN cord-023095-4dannjjm 2824 18 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2824 19 disease disease NN cord-023095-4dannjjm 2824 20 has have VBZ cord-023095-4dannjjm 2824 21 not not RB cord-023095-4dannjjm 2824 22 yet yet RB cord-023095-4dannjjm 2824 23 been be VBN cord-023095-4dannjjm 2824 24 reported report VBN cord-023095-4dannjjm 2824 25 . . . cord-023095-4dannjjm 2825 1 Also also RB cord-023095-4dannjjm 2825 2 , , , cord-023095-4dannjjm 2825 3 there there EX cord-023095-4dannjjm 2825 4 is be VBZ cord-023095-4dannjjm 2825 5 limited limited JJ cord-023095-4dannjjm 2825 6 information information NN cord-023095-4dannjjm 2825 7 about about IN cord-023095-4dannjjm 2825 8 the the DT cord-023095-4dannjjm 2825 9 stability stability NN cord-023095-4dannjjm 2825 10 of of IN cord-023095-4dannjjm 2825 11 CPE CPE NNP cord-023095-4dannjjm 2825 12 in in IN cord-023095-4dannjjm 2825 13 fecal fecal JJ cord-023095-4dannjjm 2825 14 samples sample NNS cord-023095-4dannjjm 2825 15 at at IN cord-023095-4dannjjm 2825 16 various various JJ cord-023095-4dannjjm 2825 17 storage storage NN cord-023095-4dannjjm 2825 18 conditions condition NNS cord-023095-4dannjjm 2825 19 . . . cord-023095-4dannjjm 2826 1 The the DT cord-023095-4dannjjm 2826 2 aim aim NN cord-023095-4dannjjm 2826 3 of of IN cord-023095-4dannjjm 2826 4 this this DT cord-023095-4dannjjm 2826 5 study study NN cord-023095-4dannjjm 2826 6 was be VBD cord-023095-4dannjjm 2826 7 to to TO cord-023095-4dannjjm 2826 8 evaluate evaluate VB cord-023095-4dannjjm 2826 9 the the DT cord-023095-4dannjjm 2826 10 prevalence prevalence NN cord-023095-4dannjjm 2826 11 of of IN cord-023095-4dannjjm 2826 12 the the DT cord-023095-4dannjjm 2826 13 cpe cpe NNP cord-023095-4dannjjm 2826 14 - - HYPH cord-023095-4dannjjm 2826 15 gene gene NNP cord-023095-4dannjjm 2826 16 and and CC cord-023095-4dannjjm 2826 17 CPE CPE NNP cord-023095-4dannjjm 2826 18 and and CC cord-023095-4dannjjm 2826 19 the the DT cord-023095-4dannjjm 2826 20 stability stability NN cord-023095-4dannjjm 2826 21 of of IN cord-023095-4dannjjm 2826 22 CPE CPE NNP cord-023095-4dannjjm 2826 23 in in IN cord-023095-4dannjjm 2826 24 fecal fecal JJ cord-023095-4dannjjm 2826 25 samples sample NNS cord-023095-4dannjjm 2826 26 from from IN cord-023095-4dannjjm 2826 27 dogs dog NNS cord-023095-4dannjjm 2826 28 and and CC cord-023095-4dannjjm 2826 29 cats cat NNS cord-023095-4dannjjm 2826 30 . . . cord-023095-4dannjjm 2827 1 To to TO cord-023095-4dannjjm 2827 2 evaluate evaluate VB cord-023095-4dannjjm 2827 3 the the DT cord-023095-4dannjjm 2827 4 prevalence prevalence NN cord-023095-4dannjjm 2827 5 of of IN cord-023095-4dannjjm 2827 6 the the DT cord-023095-4dannjjm 2827 7 cpe cpe NNP cord-023095-4dannjjm 2827 8 - - HYPH cord-023095-4dannjjm 2827 9 gene gene NNP cord-023095-4dannjjm 2827 10 , , , cord-023095-4dannjjm 2827 11 a a DT cord-023095-4dannjjm 2827 12 total total NN cord-023095-4dannjjm 2827 13 of of IN cord-023095-4dannjjm 2827 14 481 481 CD cord-023095-4dannjjm 2827 15 fecal fecal JJ cord-023095-4dannjjm 2827 16 samples sample NNS cord-023095-4dannjjm 2827 17 from from IN cord-023095-4dannjjm 2827 18 dogs dog NNS cord-023095-4dannjjm 2827 19 and and CC cord-023095-4dannjjm 2827 20 cats cat NNS cord-023095-4dannjjm 2827 21 with with IN cord-023095-4dannjjm 2827 22 clinical clinical JJ cord-023095-4dannjjm 2827 23 signs sign NNS cord-023095-4dannjjm 2827 24 of of IN cord-023095-4dannjjm 2827 25 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2827 26 disease disease NN cord-023095-4dannjjm 2827 27 ( ( -LRB- cord-023095-4dannjjm 2827 28 273 273 CD cord-023095-4dannjjm 2827 29 dogs dog NNS cord-023095-4dannjjm 2827 30 and and CC cord-023095-4dannjjm 2827 31 208 208 CD cord-023095-4dannjjm 2827 32 cats cat NNS cord-023095-4dannjjm 2827 33 ) ) -RRB- cord-023095-4dannjjm 2827 34 and and CC cord-023095-4dannjjm 2827 35 109 109 CD cord-023095-4dannjjm 2827 36 fecal fecal JJ cord-023095-4dannjjm 2827 37 samples sample NNS cord-023095-4dannjjm 2827 38 from from IN cord-023095-4dannjjm 2827 39 those those DT cord-023095-4dannjjm 2827 40 without without IN cord-023095-4dannjjm 2827 41 such such JJ cord-023095-4dannjjm 2827 42 signs sign NNS cord-023095-4dannjjm 2827 43 ( ( -LRB- cord-023095-4dannjjm 2827 44 80 80 CD cord-023095-4dannjjm 2827 45 dogs dog NNS cord-023095-4dannjjm 2827 46 and and CC cord-023095-4dannjjm 2827 47 29 29 CD cord-023095-4dannjjm 2827 48 cats cat NNS cord-023095-4dannjjm 2827 49 ) ) -RRB- cord-023095-4dannjjm 2827 50 were be VBD cord-023095-4dannjjm 2827 51 examined examine VBN cord-023095-4dannjjm 2827 52 using use VBG cord-023095-4dannjjm 2827 53 PCR PCR NNP cord-023095-4dannjjm 2827 54 . . . cord-023095-4dannjjm 2828 1 To to TO cord-023095-4dannjjm 2828 2 evaluate evaluate VB cord-023095-4dannjjm 2828 3 the the DT cord-023095-4dannjjm 2828 4 prevalence prevalence NN cord-023095-4dannjjm 2828 5 of of IN cord-023095-4dannjjm 2828 6 CPE CPE NNP cord-023095-4dannjjm 2828 7 , , , cord-023095-4dannjjm 2828 8 a a DT cord-023095-4dannjjm 2828 9 total total NN cord-023095-4dannjjm 2828 10 of of IN cord-023095-4dannjjm 2828 11 90 90 CD cord-023095-4dannjjm 2828 12 fecal fecal JJ cord-023095-4dannjjm 2828 13 samples sample NNS cord-023095-4dannjjm 2828 14 from from IN cord-023095-4dannjjm 2828 15 dogs dog NNS cord-023095-4dannjjm 2828 16 and and CC cord-023095-4dannjjm 2828 17 cats cat NNS cord-023095-4dannjjm 2828 18 with with IN cord-023095-4dannjjm 2828 19 clinical clinical JJ cord-023095-4dannjjm 2828 20 signs sign NNS cord-023095-4dannjjm 2828 21 of of IN cord-023095-4dannjjm 2828 22 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2828 23 disease disease NN cord-023095-4dannjjm 2828 24 ( ( -LRB- cord-023095-4dannjjm 2828 25 31 31 CD cord-023095-4dannjjm 2828 26 dogs dog NNS cord-023095-4dannjjm 2828 27 and and CC cord-023095-4dannjjm 2828 28 59 59 CD cord-023095-4dannjjm 2828 29 cats cat NNS cord-023095-4dannjjm 2828 30 ) ) -RRB- cord-023095-4dannjjm 2828 31 and and CC cord-023095-4dannjjm 2828 32 11 11 CD cord-023095-4dannjjm 2828 33 dogs dog NNS cord-023095-4dannjjm 2828 34 without without IN cord-023095-4dannjjm 2828 35 such such JJ cord-023095-4dannjjm 2828 36 signs sign NNS cord-023095-4dannjjm 2828 37 were be VBD cord-023095-4dannjjm 2828 38 evaluated evaluate VBN cord-023095-4dannjjm 2828 39 using use VBG cord-023095-4dannjjm 2828 40 a a DT cord-023095-4dannjjm 2828 41 commercially commercially RB cord-023095-4dannjjm 2828 42 available available JJ cord-023095-4dannjjm 2828 43 ELISA ELISA NNP cord-023095-4dannjjm 2828 44 kit kit NN cord-023095-4dannjjm 2828 45 ( ( -LRB- cord-023095-4dannjjm 2828 46 TechLab TechLab NNP cord-023095-4dannjjm 2828 47 , , , cord-023095-4dannjjm 2828 48 Blacksburg Blacksburg NNP cord-023095-4dannjjm 2828 49 , , , cord-023095-4dannjjm 2828 50 VA VA NNP cord-023095-4dannjjm 2828 51 ) ) -RRB- cord-023095-4dannjjm 2828 52 . . . cord-023095-4dannjjm 2829 1 The the DT cord-023095-4dannjjm 2829 2 results result NNS cord-023095-4dannjjm 2829 3 were be VBD cord-023095-4dannjjm 2829 4 analyzed analyze VBN cord-023095-4dannjjm 2829 5 using use VBG cord-023095-4dannjjm 2829 6 a a DT cord-023095-4dannjjm 2829 7 Fisher Fisher NNP cord-023095-4dannjjm 2829 8 's 's POS cord-023095-4dannjjm 2829 9 exact exact JJ cord-023095-4dannjjm 2829 10 test test NN cord-023095-4dannjjm 2829 11 . . . cord-023095-4dannjjm 2830 1 Significance significance NN cord-023095-4dannjjm 2830 2 was be VBD cord-023095-4dannjjm 2830 3 set set VBN cord-023095-4dannjjm 2830 4 at at IN cord-023095-4dannjjm 2830 5 p p NN cord-023095-4dannjjm 2830 6 o o NN cord-023095-4dannjjm 2830 7 0.05 0.05 CD cord-023095-4dannjjm 2830 8 . . . cord-023095-4dannjjm 2831 1 To to TO cord-023095-4dannjjm 2831 2 evaluate evaluate VB cord-023095-4dannjjm 2831 3 the the DT cord-023095-4dannjjm 2831 4 stability stability NN cord-023095-4dannjjm 2831 5 of of IN cord-023095-4dannjjm 2831 6 CPE CPE NNP cord-023095-4dannjjm 2831 7 , , , cord-023095-4dannjjm 2831 8 8 8 CD cord-023095-4dannjjm 2831 9 fecal fecal JJ cord-023095-4dannjjm 2831 10 samples sample NNS cord-023095-4dannjjm 2831 11 from from IN cord-023095-4dannjjm 2831 12 dogs dog NNS cord-023095-4dannjjm 2831 13 and and CC cord-023095-4dannjjm 2831 14 2 2 CD cord-023095-4dannjjm 2831 15 from from IN cord-023095-4dannjjm 2831 16 cats cat NNS cord-023095-4dannjjm 2831 17 with with IN cord-023095-4dannjjm 2831 18 clinical clinical JJ cord-023095-4dannjjm 2831 19 signs sign NNS cord-023095-4dannjjm 2831 20 of of IN cord-023095-4dannjjm 2831 21 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2831 22 disease disease NN cord-023095-4dannjjm 2831 23 that that WDT cord-023095-4dannjjm 2831 24 were be VBD cord-023095-4dannjjm 2831 25 positive positive JJ cord-023095-4dannjjm 2831 26 for for IN cord-023095-4dannjjm 2831 27 CPE CPE NNP cord-023095-4dannjjm 2831 28 were be VBD cord-023095-4dannjjm 2831 29 examined examine VBN cord-023095-4dannjjm 2831 30 . . . cord-023095-4dannjjm 2832 1 Also also RB cord-023095-4dannjjm 2832 2 , , , cord-023095-4dannjjm 2832 3 5 5 CD cord-023095-4dannjjm 2832 4 CPE CPE NNP cord-023095-4dannjjm 2832 5 negative negative JJ cord-023095-4dannjjm 2832 6 samples sample NNS cord-023095-4dannjjm 2832 7 from from IN cord-023095-4dannjjm 2832 8 dogs dog NNS cord-023095-4dannjjm 2832 9 were be VBD cord-023095-4dannjjm 2832 10 evaluated evaluate VBN cord-023095-4dannjjm 2832 11 as as IN cord-023095-4dannjjm 2832 12 negative negative JJ cord-023095-4dannjjm 2832 13 controls control NNS cord-023095-4dannjjm 2832 14 . . . cord-023095-4dannjjm 2833 1 Each each DT cord-023095-4dannjjm 2833 2 sample sample NN cord-023095-4dannjjm 2833 3 was be VBD cord-023095-4dannjjm 2833 4 subdivided subdivide VBN cord-023095-4dannjjm 2833 5 into into IN cord-023095-4dannjjm 2833 6 8 8 CD cord-023095-4dannjjm 2833 7 aliquots aliquot NNS cord-023095-4dannjjm 2833 8 and and CC cord-023095-4dannjjm 2833 9 evaluated evaluate VBN cord-023095-4dannjjm 2833 10 on on IN cord-023095-4dannjjm 2833 11 day day NN cord-023095-4dannjjm 2833 12 0 0 CD cord-023095-4dannjjm 2833 13 ; ; : cord-023095-4dannjjm 2833 14 on on IN cord-023095-4dannjjm 2833 15 days day NNS cord-023095-4dannjjm 2833 16 2 2 CD cord-023095-4dannjjm 2833 17 , , , cord-023095-4dannjjm 2833 18 5 5 CD cord-023095-4dannjjm 2833 19 , , , cord-023095-4dannjjm 2833 20 and and CC cord-023095-4dannjjm 2833 21 10 10 CD cord-023095-4dannjjm 2833 22 after after IN cord-023095-4dannjjm 2833 23 being be VBG cord-023095-4dannjjm 2833 24 stored store VBN cord-023095-4dannjjm 2833 25 at at IN cord-023095-4dannjjm 2833 26 room room NN cord-023095-4dannjjm 2833 27 temperature temperature NN cord-023095-4dannjjm 2833 28 ( ( -LRB- cord-023095-4dannjjm 2833 29 RT RT NNP cord-023095-4dannjjm 2833 30 ) ) -RRB- cord-023095-4dannjjm 2833 31 or or CC cord-023095-4dannjjm 2833 32 41C 41c CD cord-023095-4dannjjm 2833 33 ; ; : cord-023095-4dannjjm 2833 34 and and CC cord-023095-4dannjjm 2833 35 on on IN cord-023095-4dannjjm 2833 36 day day NN cord-023095-4dannjjm 2833 37 10 10 CD cord-023095-4dannjjm 2833 38 after after IN cord-023095-4dannjjm 2833 39 being be VBG cord-023095-4dannjjm 2833 40 stored store VBN cord-023095-4dannjjm 2833 41 at at IN cord-023095-4dannjjm 2833 42 À201C. À201C. NNS cord-023095-4dannjjm 2834 1 The the DT cord-023095-4dannjjm 2834 2 prevalence prevalence NN cord-023095-4dannjjm 2834 3 of of IN cord-023095-4dannjjm 2834 4 the the DT cord-023095-4dannjjm 2834 5 cpe cpe NNP cord-023095-4dannjjm 2834 6 - - HYPH cord-023095-4dannjjm 2834 7 gene gene NN cord-023095-4dannjjm 2834 8 was be VBD cord-023095-4dannjjm 2834 9 not not RB cord-023095-4dannjjm 2834 10 significantly significantly RB cord-023095-4dannjjm 2834 11 different different JJ cord-023095-4dannjjm 2834 12 between between IN cord-023095-4dannjjm 2834 13 dogs dog NNS cord-023095-4dannjjm 2834 14 with with IN cord-023095-4dannjjm 2834 15 signs sign NNS cord-023095-4dannjjm 2834 16 of of IN cord-023095-4dannjjm 2834 17 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2834 18 disease disease NN cord-023095-4dannjjm 2834 19 ( ( -LRB- cord-023095-4dannjjm 2834 20 99/273 99/273 CD cord-023095-4dannjjm 2834 21 ; ; : cord-023095-4dannjjm 2834 22 36.3 36.3 CD cord-023095-4dannjjm 2834 23 % % NN cord-023095-4dannjjm 2834 24 ) ) -RRB- cord-023095-4dannjjm 2834 25 and and CC cord-023095-4dannjjm 2834 26 dogs dog NNS cord-023095-4dannjjm 2834 27 without without IN cord-023095-4dannjjm 2834 28 ( ( -LRB- cord-023095-4dannjjm 2834 29 27/80 27/80 CD cord-023095-4dannjjm 2834 30 ; ; : cord-023095-4dannjjm 2834 31 33.8 33.8 CD cord-023095-4dannjjm 2834 32 % % NN cord-023095-4dannjjm 2834 33 ; ; : cord-023095-4dannjjm 2834 34 p p NN cord-023095-4dannjjm 2834 35 5 5 CD cord-023095-4dannjjm 2834 36 0.79 0.79 CD cord-023095-4dannjjm 2834 37 ) ) -RRB- cord-023095-4dannjjm 2834 38 . . . cord-023095-4dannjjm 2835 1 Also also RB cord-023095-4dannjjm 2835 2 , , , cord-023095-4dannjjm 2835 3 the the DT cord-023095-4dannjjm 2835 4 prevalence prevalence NN cord-023095-4dannjjm 2835 5 of of IN cord-023095-4dannjjm 2835 6 the the DT cord-023095-4dannjjm 2835 7 cpe cpe NNP cord-023095-4dannjjm 2835 8 - - HYPH cord-023095-4dannjjm 2835 9 gene gene NN cord-023095-4dannjjm 2835 10 in in IN cord-023095-4dannjjm 2835 11 cats cat NNS cord-023095-4dannjjm 2835 12 with with IN cord-023095-4dannjjm 2835 13 signs sign NNS cord-023095-4dannjjm 2835 14 of of IN cord-023095-4dannjjm 2835 15 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2835 16 disease disease NN cord-023095-4dannjjm 2835 17 ( ( -LRB- cord-023095-4dannjjm 2835 18 80/208 80/208 CD cord-023095-4dannjjm 2835 19 ; ; : cord-023095-4dannjjm 2835 20 38.5 38.5 CD cord-023095-4dannjjm 2835 21 % % NN cord-023095-4dannjjm 2835 22 ) ) -RRB- cord-023095-4dannjjm 2835 23 was be VBD cord-023095-4dannjjm 2835 24 not not RB cord-023095-4dannjjm 2835 25 significantly significantly RB cord-023095-4dannjjm 2835 26 different different JJ cord-023095-4dannjjm 2835 27 compared compare VBN cord-023095-4dannjjm 2835 28 to to IN cord-023095-4dannjjm 2835 29 cats cat NNS cord-023095-4dannjjm 2835 30 without without IN cord-023095-4dannjjm 2835 31 ( ( -LRB- cord-023095-4dannjjm 2835 32 6/ 6/ CD cord-023095-4dannjjm 2835 33 29 29 CD cord-023095-4dannjjm 2835 34 ; ; : cord-023095-4dannjjm 2835 35 20.7 20.7 CD cord-023095-4dannjjm 2835 36 % % NN cord-023095-4dannjjm 2835 37 ; ; : cord-023095-4dannjjm 2835 38 p p NN cord-023095-4dannjjm 2835 39 5 5 CD cord-023095-4dannjjm 2835 40 0.06 0.06 CD cord-023095-4dannjjm 2835 41 ) ) -RRB- cord-023095-4dannjjm 2835 42 . . . cord-023095-4dannjjm 2836 1 PCR PCR NNP cord-023095-4dannjjm 2836 2 and and CC cord-023095-4dannjjm 2836 3 ELISA ELISA NNP cord-023095-4dannjjm 2836 4 results result NNS cord-023095-4dannjjm 2836 5 were be VBD cord-023095-4dannjjm 2836 6 available available JJ cord-023095-4dannjjm 2836 7 for for IN cord-023095-4dannjjm 2836 8 90 90 CD cord-023095-4dannjjm 2836 9 samples sample NNS cord-023095-4dannjjm 2836 10 . . . cord-023095-4dannjjm 2837 1 Of of IN cord-023095-4dannjjm 2837 2 the the DT cord-023095-4dannjjm 2837 3 65 65 CD cord-023095-4dannjjm 2837 4 PCR PCR NNP cord-023095-4dannjjm 2837 5 positive positive JJ cord-023095-4dannjjm 2837 6 samples sample NNS cord-023095-4dannjjm 2837 7 , , , cord-023095-4dannjjm 2837 8 only only RB cord-023095-4dannjjm 2837 9 6 6 CD cord-023095-4dannjjm 2837 10 ( ( -LRB- cord-023095-4dannjjm 2837 11 9.2 9.2 CD cord-023095-4dannjjm 2837 12 % % NN cord-023095-4dannjjm 2837 13 ) ) -RRB- cord-023095-4dannjjm 2837 14 were be VBD cord-023095-4dannjjm 2837 15 ELISA ELISA NNP cord-023095-4dannjjm 2837 16 positive positive JJ cord-023095-4dannjjm 2837 17 . . . cord-023095-4dannjjm 2838 1 Of of IN cord-023095-4dannjjm 2838 2 the the DT cord-023095-4dannjjm 2838 3 35 35 CD cord-023095-4dannjjm 2838 4 PCR PCR NNP cord-023095-4dannjjm 2838 5 negative negative JJ cord-023095-4dannjjm 2838 6 samples sample NNS cord-023095-4dannjjm 2838 7 , , , cord-023095-4dannjjm 2838 8 only only RB cord-023095-4dannjjm 2838 9 1 1 CD cord-023095-4dannjjm 2838 10 ( ( -LRB- cord-023095-4dannjjm 2838 11 2.9 2.9 CD cord-023095-4dannjjm 2838 12 % % NN cord-023095-4dannjjm 2838 13 ) ) -RRB- cord-023095-4dannjjm 2838 14 was be VBD cord-023095-4dannjjm 2838 15 ELISA ELISA NNP cord-023095-4dannjjm 2838 16 positive positive JJ cord-023095-4dannjjm 2838 17 . . . cord-023095-4dannjjm 2839 1 The the DT cord-023095-4dannjjm 2839 2 prevalence prevalence NN cord-023095-4dannjjm 2839 3 of of IN cord-023095-4dannjjm 2839 4 CPE CPE NNP cord-023095-4dannjjm 2839 5 was be VBD cord-023095-4dannjjm 2839 6 not not RB cord-023095-4dannjjm 2839 7 significantly significantly RB cord-023095-4dannjjm 2839 8 different different JJ cord-023095-4dannjjm 2839 9 between between IN cord-023095-4dannjjm 2839 10 dogs dog NNS cord-023095-4dannjjm 2839 11 with with IN cord-023095-4dannjjm 2839 12 clinical clinical JJ cord-023095-4dannjjm 2839 13 signs sign NNS cord-023095-4dannjjm 2839 14 of of IN cord-023095-4dannjjm 2839 15 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2839 16 disease disease NN cord-023095-4dannjjm 2839 17 ( ( -LRB- cord-023095-4dannjjm 2839 18 3/31 3/31 CD cord-023095-4dannjjm 2839 19 ; ; : cord-023095-4dannjjm 2839 20 9.7 9.7 CD cord-023095-4dannjjm 2839 21 % % NN cord-023095-4dannjjm 2839 22 ) ) -RRB- cord-023095-4dannjjm 2839 23 and and CC cord-023095-4dannjjm 2839 24 those those DT cord-023095-4dannjjm 2839 25 without without IN cord-023095-4dannjjm 2839 26 ( ( -LRB- cord-023095-4dannjjm 2839 27 1/11 1/11 CD cord-023095-4dannjjm 2839 28 ; ; : cord-023095-4dannjjm 2839 29 9.0 9.0 CD cord-023095-4dannjjm 2839 30 % % NN cord-023095-4dannjjm 2839 31 ; ; : cord-023095-4dannjjm 2839 32 p p NN cord-023095-4dannjjm 2839 33 5 5 CD cord-023095-4dannjjm 2839 34 1.0 1.0 CD cord-023095-4dannjjm 2839 35 ) ) -RRB- cord-023095-4dannjjm 2839 36 . . . cord-023095-4dannjjm 2840 1 The the DT cord-023095-4dannjjm 2840 2 prevalence prevalence NN cord-023095-4dannjjm 2840 3 of of IN cord-023095-4dannjjm 2840 4 CPE CPE NNP cord-023095-4dannjjm 2840 5 in in IN cord-023095-4dannjjm 2840 6 cats cat NNS cord-023095-4dannjjm 2840 7 with with IN cord-023095-4dannjjm 2840 8 signs sign NNS cord-023095-4dannjjm 2840 9 of of IN cord-023095-4dannjjm 2840 10 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2840 11 disease disease NN cord-023095-4dannjjm 2840 12 was be VBD cord-023095-4dannjjm 2840 13 4/59 4/59 CD cord-023095-4dannjjm 2840 14 ( ( -LRB- cord-023095-4dannjjm 2840 15 6.8 6.8 CD cord-023095-4dannjjm 2840 16 % % NN cord-023095-4dannjjm 2840 17 ) ) -RRB- cord-023095-4dannjjm 2840 18 , , , cord-023095-4dannjjm 2840 19 but but CC cord-023095-4dannjjm 2840 20 no no DT cord-023095-4dannjjm 2840 21 samples sample NNS cord-023095-4dannjjm 2840 22 from from IN cord-023095-4dannjjm 2840 23 cats cat NNS cord-023095-4dannjjm 2840 24 without without IN cord-023095-4dannjjm 2840 25 such such JJ cord-023095-4dannjjm 2840 26 signs sign NNS cord-023095-4dannjjm 2840 27 were be VBD cord-023095-4dannjjm 2840 28 available available JJ cord-023095-4dannjjm 2840 29 . . . cord-023095-4dannjjm 2841 1 When when WRB cord-023095-4dannjjm 2841 2 evaluating evaluate VBG cord-023095-4dannjjm 2841 3 the the DT cord-023095-4dannjjm 2841 4 stability stability NN cord-023095-4dannjjm 2841 5 of of IN cord-023095-4dannjjm 2841 6 CPE CPE NNP cord-023095-4dannjjm 2841 7 , , , cord-023095-4dannjjm 2841 8 results result VBZ cord-023095-4dannjjm 2841 9 for for IN cord-023095-4dannjjm 2841 10 all all DT cord-023095-4dannjjm 2841 11 aliquots aliquot NNS cord-023095-4dannjjm 2841 12 were be VBD cord-023095-4dannjjm 2841 13 consistent consistent JJ cord-023095-4dannjjm 2841 14 with with IN cord-023095-4dannjjm 2841 15 the the DT cord-023095-4dannjjm 2841 16 initial initial JJ cord-023095-4dannjjm 2841 17 result result NN cord-023095-4dannjjm 2841 18 , , , cord-023095-4dannjjm 2841 19 except except IN cord-023095-4dannjjm 2841 20 for for IN cord-023095-4dannjjm 2841 21 one one CD cord-023095-4dannjjm 2841 22 sample sample NN cord-023095-4dannjjm 2841 23 ( ( -LRB- cord-023095-4dannjjm 2841 24 on on IN cord-023095-4dannjjm 2841 25 day day NN cord-023095-4dannjjm 2841 26 5 5 CD cord-023095-4dannjjm 2841 27 , , , cord-023095-4dannjjm 2841 28 stored store VBN cord-023095-4dannjjm 2841 29 at at IN cord-023095-4dannjjm 2841 30 RT RT NNP cord-023095-4dannjjm 2841 31 , , , cord-023095-4dannjjm 2841 32 which which WDT cord-023095-4dannjjm 2841 33 was be VBD cord-023095-4dannjjm 2841 34 initially initially RB cord-023095-4dannjjm 2841 35 CPE CPE NNP cord-023095-4dannjjm 2841 36 positive positive JJ cord-023095-4dannjjm 2841 37 ) ) -RRB- cord-023095-4dannjjm 2841 38 . . . cord-023095-4dannjjm 2842 1 These these DT cord-023095-4dannjjm 2842 2 results result NNS cord-023095-4dannjjm 2842 3 indicate indicate VBP cord-023095-4dannjjm 2842 4 that that IN cord-023095-4dannjjm 2842 5 only only RB cord-023095-4dannjjm 2842 6 a a DT cord-023095-4dannjjm 2842 7 small small JJ cord-023095-4dannjjm 2842 8 proportion proportion NN cord-023095-4dannjjm 2842 9 of of IN cord-023095-4dannjjm 2842 10 samples sample NNS cord-023095-4dannjjm 2842 11 that that WDT cord-023095-4dannjjm 2842 12 are be VBP cord-023095-4dannjjm 2842 13 PCR PCR NNP cord-023095-4dannjjm 2842 14 positive positive JJ cord-023095-4dannjjm 2842 15 for for IN cord-023095-4dannjjm 2842 16 the the DT cord-023095-4dannjjm 2842 17 cpe cpe NNP cord-023095-4dannjjm 2842 18 - - HYPH cord-023095-4dannjjm 2842 19 gene gene NN cord-023095-4dannjjm 2842 20 are be VBP cord-023095-4dannjjm 2842 21 also also RB cord-023095-4dannjjm 2842 22 positive positive JJ cord-023095-4dannjjm 2842 23 for for IN cord-023095-4dannjjm 2842 24 CPE CPE NNP cord-023095-4dannjjm 2842 25 . . . cord-023095-4dannjjm 2843 1 Studies study NNS cord-023095-4dannjjm 2843 2 are be VBP cord-023095-4dannjjm 2843 3 warranted warrant VBN cord-023095-4dannjjm 2843 4 to to TO cord-023095-4dannjjm 2843 5 further further RB cord-023095-4dannjjm 2843 6 compare compare VB cord-023095-4dannjjm 2843 7 the the DT cord-023095-4dannjjm 2843 8 prevalence prevalence NN cord-023095-4dannjjm 2843 9 of of IN cord-023095-4dannjjm 2843 10 CPE CPE NNP cord-023095-4dannjjm 2843 11 among among IN cord-023095-4dannjjm 2843 12 animals animal NNS cord-023095-4dannjjm 2843 13 with with IN cord-023095-4dannjjm 2843 14 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 2843 15 disease disease NN cord-023095-4dannjjm 2843 16 and and CC cord-023095-4dannjjm 2843 17 those those DT cord-023095-4dannjjm 2843 18 without without IN cord-023095-4dannjjm 2843 19 . . . cord-023095-4dannjjm 2844 1 Furthermore furthermore RB cord-023095-4dannjjm 2844 2 , , , cord-023095-4dannjjm 2844 3 the the DT cord-023095-4dannjjm 2844 4 results result NNS cord-023095-4dannjjm 2844 5 indicate indicate VBP cord-023095-4dannjjm 2844 6 that that IN cord-023095-4dannjjm 2844 7 CPE CPE NNP cord-023095-4dannjjm 2844 8 is be VBZ cord-023095-4dannjjm 2844 9 relatively relatively RB cord-023095-4dannjjm 2844 10 stable stable JJ cord-023095-4dannjjm 2844 11 in in IN cord-023095-4dannjjm 2844 12 fecal fecal JJ cord-023095-4dannjjm 2844 13 samples sample NNS cord-023095-4dannjjm 2844 14 at at IN cord-023095-4dannjjm 2844 15 various various JJ cord-023095-4dannjjm 2844 16 storage storage NN cord-023095-4dannjjm 2844 17 temperatures temperature NNS cord-023095-4dannjjm 2844 18 . . . cord-023095-4dannjjm 2845 1 Clostridium clostridium NN cord-023095-4dannjjm 2845 2 perfringens perfringens NN cord-023095-4dannjjm 2845 3 has have VBZ cord-023095-4dannjjm 2845 4 been be VBN cord-023095-4dannjjm 2845 5 implicated implicate VBN cord-023095-4dannjjm 2845 6 as as IN cord-023095-4dannjjm 2845 7 a a DT cord-023095-4dannjjm 2845 8 cause cause NN cord-023095-4dannjjm 2845 9 of of IN cord-023095-4dannjjm 2845 10 diarrhea diarrhea NN cord-023095-4dannjjm 2845 11 in in IN cord-023095-4dannjjm 2845 12 dogs dog NNS cord-023095-4dannjjm 2845 13 . . . cord-023095-4dannjjm 2846 1 The the DT cord-023095-4dannjjm 2846 2 main main JJ cord-023095-4dannjjm 2846 3 study study NN cord-023095-4dannjjm 2846 4 objective objective NN cord-023095-4dannjjm 2846 5 was be VBD cord-023095-4dannjjm 2846 6 to to TO cord-023095-4dannjjm 2846 7 compare compare VB cord-023095-4dannjjm 2846 8 two two CD cord-023095-4dannjjm 2846 9 culture culture NN cord-023095-4dannjjm 2846 10 methods method NNS cord-023095-4dannjjm 2846 11 for for IN cord-023095-4dannjjm 2846 12 the the DT cord-023095-4dannjjm 2846 13 identification identification NN cord-023095-4dannjjm 2846 14 of of IN cord-023095-4dannjjm 2846 15 C. C. NNP cord-023095-4dannjjm 2846 16 perfringens perfringen NNS cord-023095-4dannjjm 2846 17 . . . cord-023095-4dannjjm 2847 1 A a DT cord-023095-4dannjjm 2847 2 secondary secondary JJ cord-023095-4dannjjm 2847 3 objective objective NN cord-023095-4dannjjm 2847 4 was be VBD cord-023095-4dannjjm 2847 5 to to TO cord-023095-4dannjjm 2847 6 evaluate evaluate VB cord-023095-4dannjjm 2847 7 C. C. NNP cord-023095-4dannjjm 2847 8 perfringens perfringens NN cord-023095-4dannjjm 2847 9 toxin toxin NN cord-023095-4dannjjm 2847 10 genes gene VBZ cord-023095-4dannjjm 2847 11 a a DT cord-023095-4dannjjm 2847 12 , , , cord-023095-4dannjjm 2847 13 b b NN cord-023095-4dannjjm 2847 14 , , , cord-023095-4dannjjm 2847 15 b b NN cord-023095-4dannjjm 2847 16 2 2 CD cord-023095-4dannjjm 2847 17 , , , cord-023095-4dannjjm 2847 18 e e NNP cord-023095-4dannjjm 2847 19 , , , cord-023095-4dannjjm 2847 20 ı ı NNP cord-023095-4dannjjm 2847 21 and and CC cord-023095-4dannjjm 2847 22 cpe cpe NNP cord-023095-4dannjjm 2847 23 from from IN cord-023095-4dannjjm 2847 24 canine canine JJ cord-023095-4dannjjm 2847 25 isolates isolate NNS cord-023095-4dannjjm 2847 26 using use VBG cord-023095-4dannjjm 2847 27 a a DT cord-023095-4dannjjm 2847 28 multiplex multiplex NN cord-023095-4dannjjm 2847 29 PCR pcr NN cord-023095-4dannjjm 2847 30 and and CC cord-023095-4dannjjm 2847 31 determine determine VB cord-023095-4dannjjm 2847 32 their -PRON- PRP$ cord-023095-4dannjjm 2847 33 prevalence prevalence NN cord-023095-4dannjjm 2847 34 in in IN cord-023095-4dannjjm 2847 35 a a DT cord-023095-4dannjjm 2847 36 group group NN cord-023095-4dannjjm 2847 37 of of IN cord-023095-4dannjjm 2847 38 normal normal JJ cord-023095-4dannjjm 2847 39 and and CC cord-023095-4dannjjm 2847 40 diarrheic diarrheic VBZ cord-023095-4dannjjm 2847 41 dogs dog NNS cord-023095-4dannjjm 2847 42 . . . cord-023095-4dannjjm 2848 1 Fecal fecal JJ cord-023095-4dannjjm 2848 2 samples sample NNS cord-023095-4dannjjm 2848 3 were be VBD cord-023095-4dannjjm 2848 4 collected collect VBN cord-023095-4dannjjm 2848 5 from from IN cord-023095-4dannjjm 2848 6 clinically clinically RB cord-023095-4dannjjm 2848 7 normal normal JJ cord-023095-4dannjjm 2848 8 ( ( -LRB- cord-023095-4dannjjm 2848 9 ND ND NNP cord-023095-4dannjjm 2848 10 , , , cord-023095-4dannjjm 2848 11 n n NN cord-023095-4dannjjm 2848 12 5 5 CD cord-023095-4dannjjm 2848 13 105 105 CD cord-023095-4dannjjm 2848 14 ) ) -RRB- cord-023095-4dannjjm 2848 15 and and CC cord-023095-4dannjjm 2848 16 diarrheic diarrheic VBZ cord-023095-4dannjjm 2848 17 dogs dog NNS cord-023095-4dannjjm 2848 18 ( ( -LRB- cord-023095-4dannjjm 2848 19 DD DD NNP cord-023095-4dannjjm 2848 20 , , , cord-023095-4dannjjm 2848 21 n n NN cord-023095-4dannjjm 2848 22 5 5 CD cord-023095-4dannjjm 2848 23 54 54 CD cord-023095-4dannjjm 2848 24 ) ) -RRB- cord-023095-4dannjjm 2848 25 at at IN cord-023095-4dannjjm 2848 26 a a DT cord-023095-4dannjjm 2848 27 primary primary JJ cord-023095-4dannjjm 2848 28 care care NN cord-023095-4dannjjm 2848 29 veterinary veterinary JJ cord-023095-4dannjjm 2848 30 facility facility NN cord-023095-4dannjjm 2848 31 . . . cord-023095-4dannjjm 2849 1 Isolation isolation NN cord-023095-4dannjjm 2849 2 of of IN cord-023095-4dannjjm 2849 3 C. C. NNP cord-023095-4dannjjm 2849 4 perfringens perfringen NNS cord-023095-4dannjjm 2849 5 was be VBD cord-023095-4dannjjm 2849 6 performed perform VBN cord-023095-4dannjjm 2849 7 using use VBG cord-023095-4dannjjm 2849 8 direct direct JJ cord-023095-4dannjjm 2849 9 inoculation inoculation NN cord-023095-4dannjjm 2849 10 of of IN cord-023095-4dannjjm 2849 11 feces fece NNS cord-023095-4dannjjm 2849 12 onto onto IN cord-023095-4dannjjm 2849 13 5 5 CD cord-023095-4dannjjm 2849 14 % % NN cord-023095-4dannjjm 2849 15 sheep sheep NN cord-023095-4dannjjm 2849 16 blood blood NN cord-023095-4dannjjm 2849 17 agar agar NN cord-023095-4dannjjm 2849 18 ( ( -LRB- cord-023095-4dannjjm 2849 19 SBA SBA NNP cord-023095-4dannjjm 2849 20 ) ) -RRB- cord-023095-4dannjjm 2849 21 as as RB cord-023095-4dannjjm 2849 22 well well RB cord-023095-4dannjjm 2849 23 as as IN cord-023095-4dannjjm 2849 24 enrichment enrichment NN cord-023095-4dannjjm 2849 25 of of IN cord-023095-4dannjjm 2849 26 stool stool NN cord-023095-4dannjjm 2849 27 in in IN cord-023095-4dannjjm 2849 28 BHI BHI NNP cord-023095-4dannjjm 2849 29 broth broth NN cord-023095-4dannjjm 2849 30 followed follow VBN cord-023095-4dannjjm 2849 31 by by IN cord-023095-4dannjjm 2849 32 inoculation inoculation NN cord-023095-4dannjjm 2849 33 onto onto IN cord-023095-4dannjjm 2849 34 SBA SBA NNP cord-023095-4dannjjm 2849 35 . . . cord-023095-4dannjjm 2850 1 Isolates isolate NNS cord-023095-4dannjjm 2850 2 were be VBD cord-023095-4dannjjm 2850 3 tested test VBN cord-023095-4dannjjm 2850 4 by by IN cord-023095-4dannjjm 2850 5 multiplex multiplex NN cord-023095-4dannjjm 2850 6 PCR pcr NN cord-023095-4dannjjm 2850 7 for for IN cord-023095-4dannjjm 2850 8 the the DT cord-023095-4dannjjm 2850 9 presence presence NN cord-023095-4dannjjm 2850 10 of of IN cord-023095-4dannjjm 2850 11 a a DT cord-023095-4dannjjm 2850 12 , , , cord-023095-4dannjjm 2850 13 b b NN cord-023095-4dannjjm 2850 14 , , , cord-023095-4dannjjm 2850 15 b b NN cord-023095-4dannjjm 2850 16 2 2 CD cord-023095-4dannjjm 2850 17 , , , cord-023095-4dannjjm 2850 18 e e NNP cord-023095-4dannjjm 2850 19 , , , cord-023095-4dannjjm 2850 20 ı ı NNP cord-023095-4dannjjm 2850 21 and and CC cord-023095-4dannjjm 2850 22 cpe cpe NNP cord-023095-4dannjjm 2850 23 genes gene NNS cord-023095-4dannjjm 2850 24 . . . cord-023095-4dannjjm 2851 1 C. C. NNP cord-023095-4dannjjm 2851 2 perfringens perfringen NNS cord-023095-4dannjjm 2851 3 was be VBD cord-023095-4dannjjm 2851 4 isolated isolate VBN cord-023095-4dannjjm 2851 5 from from IN cord-023095-4dannjjm 2851 6 84 84 CD cord-023095-4dannjjm 2851 7 % % NN cord-023095-4dannjjm 2851 8 ( ( -LRB- cord-023095-4dannjjm 2851 9 88/105 88/105 CD cord-023095-4dannjjm 2851 10 ) ) -RRB- cord-023095-4dannjjm 2851 11 of of IN cord-023095-4dannjjm 2851 12 ND ND NNP cord-023095-4dannjjm 2851 13 fecal fecal JJ cord-023095-4dannjjm 2851 14 samples sample NNS cord-023095-4dannjjm 2851 15 using use VBG cord-023095-4dannjjm 2851 16 direct direct JJ cord-023095-4dannjjm 2851 17 culture culture NN cord-023095-4dannjjm 2851 18 and and CC cord-023095-4dannjjm 2851 19 87.6 87.6 CD cord-023095-4dannjjm 2851 20 % % NN cord-023095-4dannjjm 2851 21 ( ( -LRB- cord-023095-4dannjjm 2851 22 92/105 92/105 CD cord-023095-4dannjjm 2851 23 ) ) -RRB- cord-023095-4dannjjm 2851 24 with with IN cord-023095-4dannjjm 2851 25 BHI BHI NNP cord-023095-4dannjjm 2851 26 enrichment enrichment NN cord-023095-4dannjjm 2851 27 ( ( -LRB- cord-023095-4dannjjm 2851 28 p p NN cord-023095-4dannjjm 2851 29 5 5 CD cord-023095-4dannjjm 2851 30 0.79 0.79 CD cord-023095-4dannjjm 2851 31 ) ) -RRB- cord-023095-4dannjjm 2851 32 . . . cord-023095-4dannjjm 2852 1 In in IN cord-023095-4dannjjm 2852 2 the the DT cord-023095-4dannjjm 2852 3 DD dd NN cord-023095-4dannjjm 2852 4 , , , cord-023095-4dannjjm 2852 5 corresponding correspond VBG cord-023095-4dannjjm 2852 6 isolation isolation NN cord-023095-4dannjjm 2852 7 rates rate NNS cord-023095-4dannjjm 2852 8 were be VBD cord-023095-4dannjjm 2852 9 90.7 90.7 CD cord-023095-4dannjjm 2852 10 % % NN cord-023095-4dannjjm 2852 11 and and CC cord-023095-4dannjjm 2852 12 93.8 93.8 CD cord-023095-4dannjjm 2852 13 % % NN cord-023095-4dannjjm 2852 14 ( ( -LRB- cord-023095-4dannjjm 2852 15 p p NN cord-023095-4dannjjm 2852 16 5 5 CD cord-023095-4dannjjm 2852 17 0.45 0.45 CD cord-023095-4dannjjm 2852 18 ) ) -RRB- cord-023095-4dannjjm 2852 19 . . . cord-023095-4dannjjm 2853 1 All all DT cord-023095-4dannjjm 2853 2 isolates isolate NNS cord-023095-4dannjjm 2853 3 possessed possess VBD cord-023095-4dannjjm 2853 4 a a DT cord-023095-4dannjjm 2853 5 toxin toxin NN cord-023095-4dannjjm 2853 6 gene gene NN cord-023095-4dannjjm 2853 7 . . . cord-023095-4dannjjm 2854 1 b b LS cord-023095-4dannjjm 2854 2 , , , cord-023095-4dannjjm 2854 3 b b NN cord-023095-4dannjjm 2854 4 2 2 CD cord-023095-4dannjjm 2854 5 , , , cord-023095-4dannjjm 2854 6 e e NNP cord-023095-4dannjjm 2854 7 , , , cord-023095-4dannjjm 2854 8 ı ı NNP cord-023095-4dannjjm 2854 9 and and CC cord-023095-4dannjjm 2854 10 cpe cpe NNP cord-023095-4dannjjm 2854 11 toxin toxin NN cord-023095-4dannjjm 2854 12 genes gene NNS cord-023095-4dannjjm 2854 13 were be VBD cord-023095-4dannjjm 2854 14 identified identify VBN cord-023095-4dannjjm 2854 15 in in IN cord-023095-4dannjjm 2854 16 4.4 4.4 CD cord-023095-4dannjjm 2854 17 % % NN cord-023095-4dannjjm 2854 18 , , , cord-023095-4dannjjm 2854 19 1.1 1.1 CD cord-023095-4dannjjm 2854 20 % % NN cord-023095-4dannjjm 2854 21 , , , cord-023095-4dannjjm 2854 22 3.3 3.3 CD cord-023095-4dannjjm 2854 23 % % NN cord-023095-4dannjjm 2854 24 , , , cord-023095-4dannjjm 2854 25 1.1 1.1 CD cord-023095-4dannjjm 2854 26 % % NN cord-023095-4dannjjm 2854 27 and and CC cord-023095-4dannjjm 2854 28 14.4 14.4 CD cord-023095-4dannjjm 2854 29 % % NN cord-023095-4dannjjm 2854 30 of of IN cord-023095-4dannjjm 2854 31 ND ND NNP cord-023095-4dannjjm 2854 32 isolates isolate NNS cord-023095-4dannjjm 2854 33 , , , cord-023095-4dannjjm 2854 34 respectively respectively RB cord-023095-4dannjjm 2854 35 . . . cord-023095-4dannjjm 2855 1 In in IN cord-023095-4dannjjm 2855 2 the the DT cord-023095-4dannjjm 2855 3 DD DD NNP cord-023095-4dannjjm 2855 4 group group NN cord-023095-4dannjjm 2855 5 , , , cord-023095-4dannjjm 2855 6 b b NN cord-023095-4dannjjm 2855 7 and and CC cord-023095-4dannjjm 2855 8 b b NN cord-023095-4dannjjm 2855 9 2 2 CD cord-023095-4dannjjm 2855 10 were be VBD cord-023095-4dannjjm 2855 11 identified identify VBN cord-023095-4dannjjm 2855 12 in in IN cord-023095-4dannjjm 2855 13 5 5 CD cord-023095-4dannjjm 2855 14 % % NN cord-023095-4dannjjm 2855 15 , , , cord-023095-4dannjjm 2855 16 e e LS cord-023095-4dannjjm 2855 17 and and CC cord-023095-4dannjjm 2855 18 ı ı NNP cord-023095-4dannjjm 2855 19 were be VBD cord-023095-4dannjjm 2855 20 not not RB cord-023095-4dannjjm 2855 21 identified identify VBN cord-023095-4dannjjm 2855 22 and and CC cord-023095-4dannjjm 2855 23 the the DT cord-023095-4dannjjm 2855 24 cpe cpe NNP cord-023095-4dannjjm 2855 25 gene gene NN cord-023095-4dannjjm 2855 26 in in IN cord-023095-4dannjjm 2855 27 16.9 16.9 CD cord-023095-4dannjjm 2855 28 % % NN cord-023095-4dannjjm 2855 29 of of IN cord-023095-4dannjjm 2855 30 isolates isolate NNS cord-023095-4dannjjm 2855 31 . . . cord-023095-4dannjjm 2856 1 BHI BHI NNP cord-023095-4dannjjm 2856 2 enrichment enrichment NN cord-023095-4dannjjm 2856 3 did do VBD cord-023095-4dannjjm 2856 4 not not RB cord-023095-4dannjjm 2856 5 significantly significantly RB cord-023095-4dannjjm 2856 6 increase increase VB cord-023095-4dannjjm 2856 7 the the DT cord-023095-4dannjjm 2856 8 yield yield NN cord-023095-4dannjjm 2856 9 of of IN cord-023095-4dannjjm 2856 10 C. C. NNP cord-023095-4dannjjm 2856 11 perfringens perfringen NNS cord-023095-4dannjjm 2856 12 compared compare VBN cord-023095-4dannjjm 2856 13 to to IN cord-023095-4dannjjm 2856 14 SBA SBA NNP cord-023095-4dannjjm 2856 15 but but CC cord-023095-4dannjjm 2856 16 increased increase VBN cord-023095-4dannjjm 2856 17 time time NN cord-023095-4dannjjm 2856 18 and and CC cord-023095-4dannjjm 2856 19 cost cost NN cord-023095-4dannjjm 2856 20 involved involve VBN cord-023095-4dannjjm 2856 21 . . . cord-023095-4dannjjm 2857 1 C. C. NNP cord-023095-4dannjjm 2857 2 perfringens perfringens NNP cord-023095-4dannjjm 2857 3 ( ( -LRB- cord-023095-4dannjjm 2857 4 p p NN cord-023095-4dannjjm 2857 5 5 5 CD cord-023095-4dannjjm 2857 6 0.64 0.64 CD cord-023095-4dannjjm 2857 7 ) ) -RRB- cord-023095-4dannjjm 2857 8 and and CC cord-023095-4dannjjm 2857 9 C. C. NNP cord-023095-4dannjjm 2857 10 perfringens perfringen VBZ cord-023095-4dannjjm 2857 11 toxin toxin NN cord-023095-4dannjjm 2857 12 genes gene NNS cord-023095-4dannjjm 2857 13 were be VBD cord-023095-4dannjjm 2857 14 present present JJ cord-023095-4dannjjm 2857 15 in in IN cord-023095-4dannjjm 2857 16 equal equal JJ cord-023095-4dannjjm 2857 17 proportions proportion NNS cord-023095-4dannjjm 2857 18 in in IN cord-023095-4dannjjm 2857 19 ND ND NNP cord-023095-4dannjjm 2857 20 and and CC cord-023095-4dannjjm 2857 21 DD DD NNP cord-023095-4dannjjm 2857 22 groups group NNS cord-023095-4dannjjm 2857 23 ( ( -LRB- cord-023095-4dannjjm 2857 24 p p NN cord-023095-4dannjjm 2857 25 ! ! . cord-023095-4dannjjm 2857 26 0.15 0.15 CD cord-023095-4dannjjm 2857 27 ) ) -RRB- cord-023095-4dannjjm 2857 28 . . . cord-023095-4dannjjm 2858 1 Culture culture NN cord-023095-4dannjjm 2858 2 of of IN cord-023095-4dannjjm 2858 3 C. C. NNP cord-023095-4dannjjm 2858 4 perfringens perfringen NNS cord-023095-4dannjjm 2858 5 and and CC cord-023095-4dannjjm 2858 6 PCR PCR NNP cord-023095-4dannjjm 2858 7 for for IN cord-023095-4dannjjm 2858 8 toxin toxin NN cord-023095-4dannjjm 2858 9 genes gene NNS cord-023095-4dannjjm 2858 10 are be VBP cord-023095-4dannjjm 2858 11 of of IN cord-023095-4dannjjm 2858 12 limited limited JJ cord-023095-4dannjjm 2858 13 diagnostic diagnostic JJ cord-023095-4dannjjm 2858 14 utility utility NN cord-023095-4dannjjm 2858 15 due due IN cord-023095-4dannjjm 2858 16 to to IN cord-023095-4dannjjm 2858 17 the the DT cord-023095-4dannjjm 2858 18 high high JJ cord-023095-4dannjjm 2858 19 prevalence prevalence NN cord-023095-4dannjjm 2858 20 of of IN cord-023095-4dannjjm 2858 21 C.perfringens c.perfringen NNS cord-023095-4dannjjm 2858 22 in in IN cord-023095-4dannjjm 2858 23 normal normal JJ cord-023095-4dannjjm 2858 24 dogs dog NNS cord-023095-4dannjjm 2858 25 and and CC cord-023095-4dannjjm 2858 26 the the DT cord-023095-4dannjjm 2858 27 lack lack NN cord-023095-4dannjjm 2858 28 of of IN cord-023095-4dannjjm 2858 29 apparent apparent JJ cord-023095-4dannjjm 2858 30 difference difference NN cord-023095-4dannjjm 2858 31 in in IN cord-023095-4dannjjm 2858 32 toxin toxin NN cord-023095-4dannjjm 2858 33 gene gene NN cord-023095-4dannjjm 2858 34 distribution distribution NN cord-023095-4dannjjm 2858 35 between between IN cord-023095-4dannjjm 2858 36 normal normal JJ cord-023095-4dannjjm 2858 37 and and CC cord-023095-4dannjjm 2858 38 diarrheic diarrheic VBZ cord-023095-4dannjjm 2858 39 dogs dog NNS cord-023095-4dannjjm 2858 40 . . . cord-023095-4dannjjm 2859 1 Endoscopic endoscopic JJ cord-023095-4dannjjm 2859 2 biopsies biopsy NNS cord-023095-4dannjjm 2859 3 are be VBP cord-023095-4dannjjm 2859 4 a a DT cord-023095-4dannjjm 2859 5 relatively relatively RB cord-023095-4dannjjm 2859 6 convenient convenient JJ cord-023095-4dannjjm 2859 7 , , , cord-023095-4dannjjm 2859 8 non non JJ cord-023095-4dannjjm 2859 9 - - JJ cord-023095-4dannjjm 2859 10 invasive invasive JJ cord-023095-4dannjjm 2859 11 test test NN cord-023095-4dannjjm 2859 12 for for IN cord-023095-4dannjjm 2859 13 feline feline JJ cord-023095-4dannjjm 2859 14 infiltrative infiltrative JJ cord-023095-4dannjjm 2859 15 intestinal intestinal JJ cord-023095-4dannjjm 2859 16 disorders disorder NNS cord-023095-4dannjjm 2859 17 . . . cord-023095-4dannjjm 2860 1 Commonly commonly RB cord-023095-4dannjjm 2860 2 , , , cord-023095-4dannjjm 2860 3 only only RB cord-023095-4dannjjm 2860 4 the the DT cord-023095-4dannjjm 2860 5 duodenum duodenum NN cord-023095-4dannjjm 2860 6 is be VBZ cord-023095-4dannjjm 2860 7 examined examine VBN cord-023095-4dannjjm 2860 8 due due IN cord-023095-4dannjjm 2860 9 to to IN cord-023095-4dannjjm 2860 10 cost cost NN cord-023095-4dannjjm 2860 11 , , , cord-023095-4dannjjm 2860 12 risks risk NNS cord-023095-4dannjjm 2860 13 and and CC cord-023095-4dannjjm 2860 14 time time NN cord-023095-4dannjjm 2860 15 required require VBN cord-023095-4dannjjm 2860 16 to to TO cord-023095-4dannjjm 2860 17 prepare prepare VB cord-023095-4dannjjm 2860 18 the the DT cord-023095-4dannjjm 2860 19 colon colon NN cord-023095-4dannjjm 2860 20 using use VBG cord-023095-4dannjjm 2860 21 lavage lavage NN cord-023095-4dannjjm 2860 22 solutions solution NNS cord-023095-4dannjjm 2860 23 , , , cord-023095-4dannjjm 2860 24 cathartics cathartic NNS cord-023095-4dannjjm 2860 25 and/or and/or CC cord-023095-4dannjjm 2860 26 enemas enema NNS cord-023095-4dannjjm 2860 27 . . . cord-023095-4dannjjm 2861 1 The the DT cord-023095-4dannjjm 2861 2 purpose purpose NN cord-023095-4dannjjm 2861 3 of of IN cord-023095-4dannjjm 2861 4 this this DT cord-023095-4dannjjm 2861 5 study study NN cord-023095-4dannjjm 2861 6 was be VBD cord-023095-4dannjjm 2861 7 to to TO cord-023095-4dannjjm 2861 8 evaluate evaluate VB cord-023095-4dannjjm 2861 9 the the DT cord-023095-4dannjjm 2861 10 consistency consistency NN cord-023095-4dannjjm 2861 11 between between IN cord-023095-4dannjjm 2861 12 endoscopic endoscopic JJ cord-023095-4dannjjm 2861 13 biopsies biopsy NNS cord-023095-4dannjjm 2861 14 of of IN cord-023095-4dannjjm 2861 15 the the DT cord-023095-4dannjjm 2861 16 duodenum duodenum NN cord-023095-4dannjjm 2861 17 and and CC cord-023095-4dannjjm 2861 18 ileum ileum NN cord-023095-4dannjjm 2861 19 in in IN cord-023095-4dannjjm 2861 20 cats cat NNS cord-023095-4dannjjm 2861 21 . . . cord-023095-4dannjjm 2862 1 Endoscopic endoscopic JJ cord-023095-4dannjjm 2862 2 biopsies biopsy NNS cord-023095-4dannjjm 2862 3 from from IN cord-023095-4dannjjm 2862 4 70 70 CD cord-023095-4dannjjm 2862 5 cats cat NNS cord-023095-4dannjjm 2862 6 which which WDT cord-023095-4dannjjm 2862 7 had have VBD cord-023095-4dannjjm 2862 8 duodenal duodenal JJ cord-023095-4dannjjm 2862 9 and and CC cord-023095-4dannjjm 2862 10 ileal ileal JJ cord-023095-4dannjjm 2862 11 tissue tissue NN cord-023095-4dannjjm 2862 12 specimens specimen NNS cord-023095-4dannjjm 2862 13 were be VBD cord-023095-4dannjjm 2862 14 evaluated evaluate VBN cord-023095-4dannjjm 2862 15 retrospectively retrospectively RB cord-023095-4dannjjm 2862 16 . . . cord-023095-4dannjjm 2863 1 All all DT cord-023095-4dannjjm 2863 2 slides slide NNS cord-023095-4dannjjm 2863 3 were be VBD cord-023095-4dannjjm 2863 4 randomized randomize VBN cord-023095-4dannjjm 2863 5 and and CC cord-023095-4dannjjm 2863 6 reviewed review VBN cord-023095-4dannjjm 2863 7 by by IN cord-023095-4dannjjm 2863 8 a a DT cord-023095-4dannjjm 2863 9 single single JJ cord-023095-4dannjjm 2863 10 pathologist pathologist NN cord-023095-4dannjjm 2863 11 ( ( -LRB- cord-023095-4dannjjm 2863 12 JM JM NNP cord-023095-4dannjjm 2863 13 ) ) -RRB- cord-023095-4dannjjm 2863 14 for for IN cord-023095-4dannjjm 2863 15 quality quality NN cord-023095-4dannjjm 2863 16 , , , cord-023095-4dannjjm 2863 17 number number NN cord-023095-4dannjjm 2863 18 of of IN cord-023095-4dannjjm 2863 19 biopsies biopsy NNS cord-023095-4dannjjm 2863 20 , , , cord-023095-4dannjjm 2863 21 and and CC cord-023095-4dannjjm 2863 22 diagnosis diagnosis NN cord-023095-4dannjjm 2863 23 according accord VBG cord-023095-4dannjjm 2863 24 to to IN cord-023095-4dannjjm 2863 25 WSAVA WSAVA NNP cord-023095-4dannjjm 2863 26 standards standard NNS cord-023095-4dannjjm 2863 27 . . . cord-023095-4dannjjm 2864 1 No no DT cord-023095-4dannjjm 2864 2 information information NN cord-023095-4dannjjm 2864 3 regarding regard VBG cord-023095-4dannjjm 2864 4 history history NN cord-023095-4dannjjm 2864 5 , , , cord-023095-4dannjjm 2864 6 clinical clinical JJ cord-023095-4dannjjm 2864 7 signs sign NNS cord-023095-4dannjjm 2864 8 , , , cord-023095-4dannjjm 2864 9 endoscopic endoscopic JJ cord-023095-4dannjjm 2864 10 findings finding NNS cord-023095-4dannjjm 2864 11 , , , cord-023095-4dannjjm 2864 12 or or CC cord-023095-4dannjjm 2864 13 previous previous JJ cord-023095-4dannjjm 2864 14 histological histological JJ cord-023095-4dannjjm 2864 15 diagnosis diagnosis NN cord-023095-4dannjjm 2864 16 was be VBD cord-023095-4dannjjm 2864 17 made make VBN cord-023095-4dannjjm 2864 18 available available JJ cord-023095-4dannjjm 2864 19 to to IN cord-023095-4dannjjm 2864 20 the the DT cord-023095-4dannjjm 2864 21 pathologist pathologist NN cord-023095-4dannjjm 2864 22 . . . cord-023095-4dannjjm 2865 1 Statistical statistical JJ cord-023095-4dannjjm 2865 2 comparison comparison NN cord-023095-4dannjjm 2865 3 of of IN cord-023095-4dannjjm 2865 4 the the DT cord-023095-4dannjjm 2865 5 diagnosis diagnosis NN cord-023095-4dannjjm 2865 6 of of IN cord-023095-4dannjjm 2865 7 SC SC NNP cord-023095-4dannjjm 2865 8 - - HYPH cord-023095-4dannjjm 2865 9 LSA LSA NNP cord-023095-4dannjjm 2865 10 and and CC cord-023095-4dannjjm 2865 11 IBD IBD NNP cord-023095-4dannjjm 2865 12 by by IN cord-023095-4dannjjm 2865 13 intestinal intestinal JJ cord-023095-4dannjjm 2865 14 location location NN cord-023095-4dannjjm 2865 15 was be VBD cord-023095-4dannjjm 2865 16 conducted conduct VBN cord-023095-4dannjjm 2865 17 using use VBG cord-023095-4dannjjm 2865 18 Fisher Fisher NNP cord-023095-4dannjjm 2865 19 's 's POS cord-023095-4dannjjm 2865 20 exact exact JJ cord-023095-4dannjjm 2865 21 test test NN cord-023095-4dannjjm 2865 22 ( ( -LRB- cord-023095-4dannjjm 2865 23 p p NN cord-023095-4dannjjm 2865 24 o o NN cord-023095-4dannjjm 2865 25 0.05 0.05 CD cord-023095-4dannjjm 2865 26 significant significant JJ cord-023095-4dannjjm 2865 27 ) ) -RRB- cord-023095-4dannjjm 2865 28 . . . cord-023095-4dannjjm 2866 1 18 18 CD cord-023095-4dannjjm 2866 2 of of IN cord-023095-4dannjjm 2866 3 70 70 CD cord-023095-4dannjjm 2866 4 cats cat NNS cord-023095-4dannjjm 2866 5 ( ( -LRB- cord-023095-4dannjjm 2866 6 25.7 25.7 CD cord-023095-4dannjjm 2866 7 % % NN cord-023095-4dannjjm 2866 8 ) ) -RRB- cord-023095-4dannjjm 2866 9 were be VBD cord-023095-4dannjjm 2866 10 diagnosed diagnose VBN cord-023095-4dannjjm 2866 11 with with IN cord-023095-4dannjjm 2866 12 SC SC NNP cord-023095-4dannjjm 2866 13 - - HYPH cord-023095-4dannjjm 2866 14 LSA LSA NNP cord-023095-4dannjjm 2866 15 in in IN cord-023095-4dannjjm 2866 16 the the DT cord-023095-4dannjjm 2866 17 duodenum duodenum NN cord-023095-4dannjjm 2866 18 and/or and/or CC cord-023095-4dannjjm 2867 1 ileum ileum NNP cord-023095-4dannjjm 2867 2 . . . cord-023095-4dannjjm 2868 1 Of of IN cord-023095-4dannjjm 2868 2 these these DT cord-023095-4dannjjm 2868 3 18 18 CD cord-023095-4dannjjm 2868 4 cats cat NNS cord-023095-4dannjjm 2868 5 , , , cord-023095-4dannjjm 2868 6 7 7 CD cord-023095-4dannjjm 2868 7 ( ( -LRB- cord-023095-4dannjjm 2868 8 38.9 38.9 CD cord-023095-4dannjjm 2868 9 % % NN cord-023095-4dannjjm 2868 10 ) ) -RRB- cord-023095-4dannjjm 2868 11 were be VBD cord-023095-4dannjjm 2868 12 diagnosed diagnose VBN cord-023095-4dannjjm 2868 13 with with IN cord-023095-4dannjjm 2868 14 only only JJ cord-023095-4dannjjm 2868 15 duodenal duodenal JJ cord-023095-4dannjjm 2868 16 SC SC NNP cord-023095-4dannjjm 2868 17 - - HYPH cord-023095-4dannjjm 2868 18 LSA LSA NNP cord-023095-4dannjjm 2868 19 , , , cord-023095-4dannjjm 2868 20 8 8 CD cord-023095-4dannjjm 2868 21 ( ( -LRB- cord-023095-4dannjjm 2868 22 44.4 44.4 CD cord-023095-4dannjjm 2868 23 % % NN cord-023095-4dannjjm 2868 24 ) ) -RRB- cord-023095-4dannjjm 2868 25 were be VBD cord-023095-4dannjjm 2868 26 diagnosed diagnose VBN cord-023095-4dannjjm 2868 27 with with IN cord-023095-4dannjjm 2868 28 only only JJ cord-023095-4dannjjm 2868 29 ileal ileal JJ cord-023095-4dannjjm 2868 30 SC SC NNP cord-023095-4dannjjm 2868 31 - - HYPH cord-023095-4dannjjm 2868 32 LSA LSA NNP cord-023095-4dannjjm 2868 33 , , , cord-023095-4dannjjm 2868 34 and and CC cord-023095-4dannjjm 2868 35 3 3 CD cord-023095-4dannjjm 2868 36 ( ( -LRB- cord-023095-4dannjjm 2868 37 16.7 16.7 CD cord-023095-4dannjjm 2868 38 % % NN cord-023095-4dannjjm 2868 39 ) ) -RRB- cord-023095-4dannjjm 2868 40 had have VBD cord-023095-4dannjjm 2868 41 SC SC NNP cord-023095-4dannjjm 2868 42 - - HYPH cord-023095-4dannjjm 2868 43 LSA LSA NNP cord-023095-4dannjjm 2868 44 in in IN cord-023095-4dannjjm 2868 45 both both CC cord-023095-4dannjjm 2868 46 duodenum duodenum NN cord-023095-4dannjjm 2868 47 and and CC cord-023095-4dannjjm 2868 48 ileum ileum NN cord-023095-4dannjjm 2868 49 . . . cord-023095-4dannjjm 2869 1 In in IN cord-023095-4dannjjm 2869 2 8 8 CD cord-023095-4dannjjm 2869 3 cats cat NNS cord-023095-4dannjjm 2869 4 with with IN cord-023095-4dannjjm 2869 5 only only JJ cord-023095-4dannjjm 2869 6 ileal ileal JJ cord-023095-4dannjjm 2869 7 SC SC NNP cord-023095-4dannjjm 2869 8 - - HYPH cord-023095-4dannjjm 2869 9 LSA LSA NNP cord-023095-4dannjjm 2869 10 , , , cord-023095-4dannjjm 2869 11 3 3 CD cord-023095-4dannjjm 2869 12 had have VBD cord-023095-4dannjjm 2869 13 severe severe JJ cord-023095-4dannjjm 2869 14 IBD IBD NNP cord-023095-4dannjjm 2869 15 in in IN cord-023095-4dannjjm 2869 16 duodenal duodenal JJ cord-023095-4dannjjm 2869 17 biopsies biopsy NNS cord-023095-4dannjjm 2869 18 , , , cord-023095-4dannjjm 2869 19 possibly possibly RB cord-023095-4dannjjm 2869 20 consistent consistent JJ cord-023095-4dannjjm 2869 21 with with IN cord-023095-4dannjjm 2869 22 early early JJ cord-023095-4dannjjm 2869 23 SC SC NNP cord-023095-4dannjjm 2869 24 - - HYPH cord-023095-4dannjjm 2869 25 LSA LSA NNP cord-023095-4dannjjm 2869 26 . . . cord-023095-4dannjjm 2870 1 5 5 CD cord-023095-4dannjjm 2870 2 of of IN cord-023095-4dannjjm 2870 3 these these DT cord-023095-4dannjjm 2870 4 8 8 CD cord-023095-4dannjjm 2870 5 had have VBD cord-023095-4dannjjm 2870 6 duodenal duodenal JJ cord-023095-4dannjjm 2870 7 biopsies biopsy NNS cord-023095-4dannjjm 2870 8 without without IN cord-023095-4dannjjm 2870 9 evidence evidence NN cord-023095-4dannjjm 2870 10 of of IN cord-023095-4dannjjm 2870 11 SC SC NNP cord-023095-4dannjjm 2870 12 - - HYPH cord-023095-4dannjjm 2870 13 LSA LSA NNP cord-023095-4dannjjm 2870 14 . . . cord-023095-4dannjjm 2871 1 Our -PRON- PRP$ cord-023095-4dannjjm 2871 2 results result NNS cord-023095-4dannjjm 2871 3 suggest suggest VBP cord-023095-4dannjjm 2871 4 there there EX cord-023095-4dannjjm 2871 5 is be VBZ cord-023095-4dannjjm 2871 6 a a DT cord-023095-4dannjjm 2871 7 population population NN cord-023095-4dannjjm 2871 8 of of IN cord-023095-4dannjjm 2871 9 cats cat NNS cord-023095-4dannjjm 2871 10 in in IN cord-023095-4dannjjm 2871 11 which which WDT cord-023095-4dannjjm 2871 12 diagnosis diagnosis NN cord-023095-4dannjjm 2871 13 of of IN cord-023095-4dannjjm 2871 14 SC SC NNP cord-023095-4dannjjm 2871 15 - - HYPH cord-023095-4dannjjm 2871 16 LSA LSA NNP cord-023095-4dannjjm 2871 17 may may MD cord-023095-4dannjjm 2871 18 only only RB cord-023095-4dannjjm 2871 19 be be VB cord-023095-4dannjjm 2871 20 found find VBN cord-023095-4dannjjm 2871 21 by by IN cord-023095-4dannjjm 2871 22 evaluating evaluate VBG cord-023095-4dannjjm 2871 23 ileal ileal JJ cord-023095-4dannjjm 2871 24 biopsies biopsy NNS cord-023095-4dannjjm 2871 25 . . . cord-023095-4dannjjm 2872 1 Clinicians clinician NNS cord-023095-4dannjjm 2872 2 should should MD cord-023095-4dannjjm 2872 3 consider consider VB cord-023095-4dannjjm 2872 4 performing perform VBG cord-023095-4dannjjm 2872 5 both both DT cord-023095-4dannjjm 2872 6 upper upper JJ cord-023095-4dannjjm 2872 7 and and CC cord-023095-4dannjjm 2872 8 lower low JJR cord-023095-4dannjjm 2872 9 GI GI NNP cord-023095-4dannjjm 2872 10 endoscopic endoscopic NN cord-023095-4dannjjm 2872 11 biopsies biopsy NNS cord-023095-4dannjjm 2872 12 in in IN cord-023095-4dannjjm 2872 13 cats cat NNS cord-023095-4dannjjm 2872 14 with with IN cord-023095-4dannjjm 2872 15 suspected suspect VBN cord-023095-4dannjjm 2872 16 infiltrative infiltrative JJ cord-023095-4dannjjm 2872 17 small small JJ cord-023095-4dannjjm 2872 18 bowel bowel NN cord-023095-4dannjjm 2872 19 disease disease NN cord-023095-4dannjjm 2872 20 . . . cord-023095-4dannjjm 2873 1 Periodontitis Periodontitis NNP cord-023095-4dannjjm 2873 2 is be VBZ cord-023095-4dannjjm 2873 3 one one CD cord-023095-4dannjjm 2873 4 of of IN cord-023095-4dannjjm 2873 5 the the DT cord-023095-4dannjjm 2873 6 most most RBS cord-023095-4dannjjm 2873 7 common common JJ cord-023095-4dannjjm 2873 8 diseases disease NNS cord-023095-4dannjjm 2873 9 in in IN cord-023095-4dannjjm 2873 10 cats cat NNS cord-023095-4dannjjm 2873 11 and and CC cord-023095-4dannjjm 2873 12 is be VBZ cord-023095-4dannjjm 2873 13 mainly mainly RB cord-023095-4dannjjm 2873 14 due due JJ cord-023095-4dannjjm 2873 15 to to IN cord-023095-4dannjjm 2873 16 the the DT cord-023095-4dannjjm 2873 17 presence presence NN cord-023095-4dannjjm 2873 18 of of IN cord-023095-4dannjjm 2873 19 plaque plaque NN cord-023095-4dannjjm 2873 20 and and CC cord-023095-4dannjjm 2873 21 calculus calculus NN cord-023095-4dannjjm 2873 22 . . . cord-023095-4dannjjm 2874 1 In in IN cord-023095-4dannjjm 2874 2 this this DT cord-023095-4dannjjm 2874 3 study study NN cord-023095-4dannjjm 2874 4 , , , cord-023095-4dannjjm 2874 5 we -PRON- PRP cord-023095-4dannjjm 2874 6 investigated investigate VBD cord-023095-4dannjjm 2874 7 putative putative JJ cord-023095-4dannjjm 2874 8 correlations correlation NNS cord-023095-4dannjjm 2874 9 between between IN cord-023095-4dannjjm 2874 10 dental dental JJ cord-023095-4dannjjm 2874 11 tartar tartar NN cord-023095-4dannjjm 2874 12 and and CC cord-023095-4dannjjm 2874 13 gingivitis gingivitis NN cord-023095-4dannjjm 2874 14 and and CC cord-023095-4dannjjm 2874 15 also also RB cord-023095-4dannjjm 2874 16 between between IN cord-023095-4dannjjm 2874 17 gingivitis gingivitis NN cord-023095-4dannjjm 2874 18 and and CC cord-023095-4dannjjm 2874 19 subgingival subgingival NN cord-023095-4dannjjm 2874 20 bacteria bacteria NNS cord-023095-4dannjjm 2874 21 in in IN cord-023095-4dannjjm 2874 22 cats cat NNS cord-023095-4dannjjm 2874 23 . . . cord-023095-4dannjjm 2875 1 Twelve twelve CD cord-023095-4dannjjm 2875 2 cats cat NNS cord-023095-4dannjjm 2875 3 ( ( -LRB- cord-023095-4dannjjm 2875 4 median median JJ cord-023095-4dannjjm 2875 5 age age NN cord-023095-4dannjjm 2875 6 : : : cord-023095-4dannjjm 2875 7 5 5 CD cord-023095-4dannjjm 2875 8 years year NNS cord-023095-4dannjjm 2875 9 ; ; : cord-023095-4dannjjm 2875 10 range range NN cord-023095-4dannjjm 2875 11 : : : cord-023095-4dannjjm 2875 12 1 1 CD cord-023095-4dannjjm 2875 13 - - SYM cord-023095-4dannjjm 2875 14 10 10 CD cord-023095-4dannjjm 2875 15 years year NNS cord-023095-4dannjjm 2875 16 ; ; : cord-023095-4dannjjm 2875 17 6 6 CD cord-023095-4dannjjm 2875 18 DSH DSH NNP cord-023095-4dannjjm 2875 19 and and CC cord-023095-4dannjjm 2875 20 6 6 CD cord-023095-4dannjjm 2875 21 Persians Persians NNPS cord-023095-4dannjjm 2875 22 ; ; : cord-023095-4dannjjm 2875 23 8 8 CD cord-023095-4dannjjm 2875 24 females female NNS cord-023095-4dannjjm 2875 25 and and CC cord-023095-4dannjjm 2875 26 4 4 CD cord-023095-4dannjjm 2875 27 males male NNS cord-023095-4dannjjm 2875 28 ) ) -RRB- cord-023095-4dannjjm 2875 29 were be VBD cord-023095-4dannjjm 2875 30 enrolled enrol VBN cord-023095-4dannjjm 2875 31 . . . cord-023095-4dannjjm 2876 1 Dental dental JJ cord-023095-4dannjjm 2876 2 tartar tartar NN cord-023095-4dannjjm 2876 3 was be VBD cord-023095-4dannjjm 2876 4 obtained obtain VBN cord-023095-4dannjjm 2876 5 during during IN cord-023095-4dannjjm 2876 6 scaling scale VBG cord-023095-4dannjjm 2876 7 for for IN cord-023095-4dannjjm 2876 8 a a DT cord-023095-4dannjjm 2876 9 dental dental JJ cord-023095-4dannjjm 2876 10 prophylactic prophylactic JJ cord-023095-4dannjjm 2876 11 procedure procedure NN cord-023095-4dannjjm 2876 12 . . . cord-023095-4dannjjm 2877 1 All all DT cord-023095-4dannjjm 2877 2 cats cat NNS cord-023095-4dannjjm 2877 3 were be VBD cord-023095-4dannjjm 2877 4 negative negative JJ cord-023095-4dannjjm 2877 5 for for IN cord-023095-4dannjjm 2877 6 FeLV FeLV NNP cord-023095-4dannjjm 2877 7 and and CC cord-023095-4dannjjm 2877 8 FIV FIV NNP cord-023095-4dannjjm 2877 9 infection infection NN cord-023095-4dannjjm 2877 10 as as IN cord-023095-4dannjjm 2877 11 assessed assess VBN cord-023095-4dannjjm 2877 12 by by IN cord-023095-4dannjjm 2877 13 a a DT cord-023095-4dannjjm 2877 14 commercial commercial JJ cord-023095-4dannjjm 2877 15 ELISA ELISA NNP cord-023095-4dannjjm 2877 16 test test NN cord-023095-4dannjjm 2877 17 ( ( -LRB- cord-023095-4dannjjm 2877 18 SNAP snap VB cord-023095-4dannjjm 2877 19 s s PRP cord-023095-4dannjjm 2877 20 FIV FIV NNP cord-023095-4dannjjm 2877 21 / / SYM cord-023095-4dannjjm 2877 22 FeLV FeLV NNP cord-023095-4dannjjm 2877 23 Combo Combo NNP cord-023095-4dannjjm 2877 24 Test Test NNP cord-023095-4dannjjm 2877 25 ) ) -RRB- cord-023095-4dannjjm 2877 26 . . . cord-023095-4dannjjm 2878 1 Severity severity NN cord-023095-4dannjjm 2878 2 of of IN cord-023095-4dannjjm 2878 3 gingivitis gingivitis NN cord-023095-4dannjjm 2878 4 ( ( -LRB- cord-023095-4dannjjm 2878 5 scores score NNS cord-023095-4dannjjm 2878 6 : : : cord-023095-4dannjjm 2878 7 0 0 CD cord-023095-4dannjjm 2878 8 - - SYM cord-023095-4dannjjm 2878 9 3 3 CD cord-023095-4dannjjm 2878 10 ; ; : cord-023095-4dannjjm 2878 11 0 0 CD cord-023095-4dannjjm 2878 12 5 5 CD cord-023095-4dannjjm 2878 13 normal normal JJ cord-023095-4dannjjm 2878 14 , , , cord-023095-4dannjjm 2878 15 1 1 CD cord-023095-4dannjjm 2878 16 5 5 CD cord-023095-4dannjjm 2878 17 mild mild JJ cord-023095-4dannjjm 2878 18 , , , cord-023095-4dannjjm 2878 19 2 2 CD cord-023095-4dannjjm 2878 20 5 5 CD cord-023095-4dannjjm 2878 21 moderate moderate JJ cord-023095-4dannjjm 2878 22 , , , cord-023095-4dannjjm 2878 23 and and CC cord-023095-4dannjjm 2878 24 3 3 CD cord-023095-4dannjjm 2878 25 5 5 CD cord-023095-4dannjjm 2878 26 severe severe JJ cord-023095-4dannjjm 2878 27 ) ) -RRB- cord-023095-4dannjjm 2878 28 and and CC cord-023095-4dannjjm 2878 29 dental dental JJ cord-023095-4dannjjm 2878 30 tartar tartar NN cord-023095-4dannjjm 2878 31 ( ( -LRB- cord-023095-4dannjjm 2878 32 scores score NNS cord-023095-4dannjjm 2878 33 : : : cord-023095-4dannjjm 2878 34 0 0 CD cord-023095-4dannjjm 2878 35 - - SYM cord-023095-4dannjjm 2878 36 3 3 CD cord-023095-4dannjjm 2878 37 ) ) -RRB- cord-023095-4dannjjm 2878 38 were be VBD cord-023095-4dannjjm 2878 39 scored score VBN cord-023095-4dannjjm 2878 40 in in IN cord-023095-4dannjjm 2878 41 each each DT cord-023095-4dannjjm 2878 42 cat cat NN cord-023095-4dannjjm 2878 43 . . . cord-023095-4dannjjm 2879 1 Endodontic endodontic JJ cord-023095-4dannjjm 2879 2 paper paper NN cord-023095-4dannjjm 2879 3 points point NNS cord-023095-4dannjjm 2879 4 were be VBD cord-023095-4dannjjm 2879 5 applied apply VBN cord-023095-4dannjjm 2879 6 for for IN cord-023095-4dannjjm 2879 7 collecting collect VBG cord-023095-4dannjjm 2879 8 a a DT cord-023095-4dannjjm 2879 9 bacterial bacterial JJ cord-023095-4dannjjm 2879 10 sample sample NN cord-023095-4dannjjm 2879 11 from from IN cord-023095-4dannjjm 2879 12 the the DT cord-023095-4dannjjm 2879 13 subgingival subgingival NNP cord-023095-4dannjjm 2879 14 area area NN cord-023095-4dannjjm 2879 15 and and CC cord-023095-4dannjjm 2879 16 transferred transfer VBN cord-023095-4dannjjm 2879 17 to to IN cord-023095-4dannjjm 2879 18 thioglycollate thioglycollate JJ cord-023095-4dannjjm 2879 19 transporting transport VBG cord-023095-4dannjjm 2879 20 media medium NNS cord-023095-4dannjjm 2879 21 for for IN cord-023095-4dannjjm 2879 22 bacterial bacterial JJ cord-023095-4dannjjm 2879 23 culture culture NN cord-023095-4dannjjm 2879 24 . . . cord-023095-4dannjjm 2880 1 The the DT cord-023095-4dannjjm 2880 2 relationship relationship NN cord-023095-4dannjjm 2880 3 between between IN cord-023095-4dannjjm 2880 4 gingivitis gingivitis NN cord-023095-4dannjjm 2880 5 and and CC cord-023095-4dannjjm 2880 6 tartar tartar NN cord-023095-4dannjjm 2880 7 thickness thickness NN cord-023095-4dannjjm 2880 8 scores score NNS cord-023095-4dannjjm 2880 9 was be VBD cord-023095-4dannjjm 2880 10 analyzed analyze VBN cord-023095-4dannjjm 2880 11 by by IN cord-023095-4dannjjm 2880 12 spearman spearman NNP cord-023095-4dannjjm 2880 13 correlation correlation NN cord-023095-4dannjjm 2880 14 . . . cord-023095-4dannjjm 2881 1 A a DT cord-023095-4dannjjm 2881 2 student student NN cord-023095-4dannjjm 2881 3 's 's POS cord-023095-4dannjjm 2881 4 t t NN cord-023095-4dannjjm 2881 5 - - HYPH cord-023095-4dannjjm 2881 6 test test NN cord-023095-4dannjjm 2881 7 was be VBD cord-023095-4dannjjm 2881 8 used use VBN cord-023095-4dannjjm 2881 9 to to TO cord-023095-4dannjjm 2881 10 compare compare VB cord-023095-4dannjjm 2881 11 the the DT cord-023095-4dannjjm 2881 12 mean mean JJ cord-023095-4dannjjm 2881 13 differences difference NNS cord-023095-4dannjjm 2881 14 ( ( -LRB- cord-023095-4dannjjm 2881 15 gingivitis gingivitis NN cord-023095-4dannjjm 2881 16 and and CC cord-023095-4dannjjm 2881 17 tartar tartar NN cord-023095-4dannjjm 2881 18 thickness thickness NN cord-023095-4dannjjm 2881 19 scores score NNS cord-023095-4dannjjm 2881 20 ) ) -RRB- cord-023095-4dannjjm 2881 21 between between IN cord-023095-4dannjjm 2881 22 upper upper JJ cord-023095-4dannjjm 2881 23 and and CC cord-023095-4dannjjm 2881 24 lower low JJR cord-023095-4dannjjm 2881 25 teeth tooth NNS cord-023095-4dannjjm 2881 26 . . . cord-023095-4dannjjm 2882 1 The the DT cord-023095-4dannjjm 2882 2 association association NN cord-023095-4dannjjm 2882 3 between between IN cord-023095-4dannjjm 2882 4 severity severity NN cord-023095-4dannjjm 2882 5 of of IN cord-023095-4dannjjm 2882 6 gingivitis gingivitis NN cord-023095-4dannjjm 2882 7 and and CC cord-023095-4dannjjm 2882 8 bacterial bacterial JJ cord-023095-4dannjjm 2882 9 type type NN cord-023095-4dannjjm 2882 10 was be VBD cord-023095-4dannjjm 2882 11 tested test VBN cord-023095-4dannjjm 2882 12 by by IN cord-023095-4dannjjm 2882 13 chi chi NNP cord-023095-4dannjjm 2882 14 square square NNP cord-023095-4dannjjm 2882 15 test test NN cord-023095-4dannjjm 2882 16 . . . cord-023095-4dannjjm 2883 1 The the DT cord-023095-4dannjjm 2883 2 spearman spearman NN cord-023095-4dannjjm 2883 3 correlation correlation NN cord-023095-4dannjjm 2883 4 coefficient coefficient NN cord-023095-4dannjjm 2883 5 for for IN cord-023095-4dannjjm 2883 6 the the DT cord-023095-4dannjjm 2883 7 average average JJ cord-023095-4dannjjm 2883 8 gingivitis gingivitis NN cord-023095-4dannjjm 2883 9 score score NN cord-023095-4dannjjm 2883 10 and and CC cord-023095-4dannjjm 2883 11 the the DT cord-023095-4dannjjm 2883 12 average average JJ cord-023095-4dannjjm 2883 13 tartar tartar NN cord-023095-4dannjjm 2883 14 thickness thickness NN cord-023095-4dannjjm 2883 15 score score NN cord-023095-4dannjjm 2883 16 was be VBD cord-023095-4dannjjm 2883 17 0.91 0.91 CD cord-023095-4dannjjm 2883 18 ( ( -LRB- cord-023095-4dannjjm 2883 19 p p NN cord-023095-4dannjjm 2883 20 o o NN cord-023095-4dannjjm 2883 21 0.05 0.05 CD cord-023095-4dannjjm 2883 22 ) ) -RRB- cord-023095-4dannjjm 2883 23 . . . cord-023095-4dannjjm 2884 1 Interestingly interestingly RB cord-023095-4dannjjm 2884 2 , , , cord-023095-4dannjjm 2884 3 the the DT cord-023095-4dannjjm 2884 4 average average JJ cord-023095-4dannjjm 2884 5 tartar tartar NN cord-023095-4dannjjm 2884 6 thickness thickness NN cord-023095-4dannjjm 2884 7 scores score NNS cord-023095-4dannjjm 2884 8 from from IN cord-023095-4dannjjm 2884 9 the the DT cord-023095-4dannjjm 2884 10 upper upper JJ cord-023095-4dannjjm 2884 11 jaw jaw NN cord-023095-4dannjjm 2884 12 were be VBD cord-023095-4dannjjm 2884 13 significantly significantly RB cord-023095-4dannjjm 2884 14 higher high JJR cord-023095-4dannjjm 2884 15 than than IN cord-023095-4dannjjm 2884 16 those those DT cord-023095-4dannjjm 2884 17 from from IN cord-023095-4dannjjm 2884 18 the the DT cord-023095-4dannjjm 2884 19 lower low JJR cord-023095-4dannjjm 2884 20 jaw jaw NN cord-023095-4dannjjm 2884 21 ( ( -LRB- cord-023095-4dannjjm 2884 22 p p NN cord-023095-4dannjjm 2884 23 o o NN cord-023095-4dannjjm 2884 24 0.05 0.05 CD cord-023095-4dannjjm 2884 25 ) ) -RRB- cord-023095-4dannjjm 2884 26 . . . cord-023095-4dannjjm 2885 1 The the DT cord-023095-4dannjjm 2885 2 highest high JJS cord-023095-4dannjjm 2885 3 scores score NNS cord-023095-4dannjjm 2885 4 were be VBD cord-023095-4dannjjm 2885 5 found find VBN cord-023095-4dannjjm 2885 6 for for IN cord-023095-4dannjjm 2885 7 the the DT cord-023095-4dannjjm 2885 8 molar molar JJ cord-023095-4dannjjm 2885 9 teeth tooth NNS cord-023095-4dannjjm 2885 10 in in IN cord-023095-4dannjjm 2885 11 all all DT cord-023095-4dannjjm 2885 12 cats cat NNS cord-023095-4dannjjm 2885 13 . . . cord-023095-4dannjjm 2886 1 Bacterial bacterial JJ cord-023095-4dannjjm 2886 2 culture culture NN cord-023095-4dannjjm 2886 3 revealed reveal VBD cord-023095-4dannjjm 2886 4 28.9 28.9 CD cord-023095-4dannjjm 2886 5 % % NN cord-023095-4dannjjm 2886 6 anaerobic anaerobic JJ cord-023095-4dannjjm 2886 7 bacteria bacteria NNS cord-023095-4dannjjm 2886 8 species specie NNS cord-023095-4dannjjm 2886 9 ( ( -LRB- cord-023095-4dannjjm 2886 10 i.e. i.e. FW cord-023095-4dannjjm 2886 11 , , , cord-023095-4dannjjm 2886 12 Bacteroides Bacteroides NNP cord-023095-4dannjjm 2886 13 spp spp NNS cord-023095-4dannjjm 2886 14 . . . cord-023095-4dannjjm 2887 1 , , , cord-023095-4dannjjm 2887 2 Peptostreptococcus Peptostreptococcus NNP cord-023095-4dannjjm 2887 3 anaerobius anaerobius NN cord-023095-4dannjjm 2887 4 , , , cord-023095-4dannjjm 2887 5 and and CC cord-023095-4dannjjm 2887 6 Eubacterium Eubacterium NNP cord-023095-4dannjjm 2887 7 aerofaciens aerofaciens NNP cord-023095-4dannjjm 2887 8 ) ) -RRB- cord-023095-4dannjjm 2887 9 and and CC cord-023095-4dannjjm 2887 10 71.1 71.1 CD cord-023095-4dannjjm 2887 11 % % NN cord-023095-4dannjjm 2887 12 aerobic aerobic JJ cord-023095-4dannjjm 2887 13 bacteria bacteria NNS cord-023095-4dannjjm 2887 14 species specie NNS cord-023095-4dannjjm 2887 15 ( ( -LRB- cord-023095-4dannjjm 2887 16 i.e. i.e. FW cord-023095-4dannjjm 2887 17 , , , cord-023095-4dannjjm 2887 18 Pasteurella Pasteurella NNP cord-023095-4dannjjm 2887 19 multocida multocida NN cord-023095-4dannjjm 2887 20 , , , cord-023095-4dannjjm 2887 21 Streptococcus Streptococcus NNP cord-023095-4dannjjm 2887 22 spp spp NNS cord-023095-4dannjjm 2887 23 . . . cord-023095-4dannjjm 2887 24 , , , cord-023095-4dannjjm 2888 1 Enterococcus Enterococcus NNP cord-023095-4dannjjm 2888 2 spp spp NNP cord-023095-4dannjjm 2888 3 . . . cord-023095-4dannjjm 2889 1 , , , cord-023095-4dannjjm 2889 2 Staphylococcus Staphylococcus NNP cord-023095-4dannjjm 2889 3 spp spp NNS cord-023095-4dannjjm 2889 4 . . . cord-023095-4dannjjm 2889 5 , , , cord-023095-4dannjjm 2889 6 Bacillus bacillus NN cord-023095-4dannjjm 2889 7 cereus cereus NN cord-023095-4dannjjm 2889 8 , , , cord-023095-4dannjjm 2889 9 Escherichia escherichia NN cord-023095-4dannjjm 2889 10 coli coli NNS cord-023095-4dannjjm 2889 11 , , , cord-023095-4dannjjm 2889 12 and and CC cord-023095-4dannjjm 2889 13 Pseudomonas Pseudomonas NNP cord-023095-4dannjjm 2889 14 aeruginosa aeruginosa NN cord-023095-4dannjjm 2889 15 ) ) -RRB- cord-023095-4dannjjm 2889 16 . . . cord-023095-4dannjjm 2890 1 Anaerobic anaerobic JJ cord-023095-4dannjjm 2890 2 bacteria bacteria NNS cord-023095-4dannjjm 2890 3 were be VBD cord-023095-4dannjjm 2890 4 found find VBN cord-023095-4dannjjm 2890 5 mostly mostly RB cord-023095-4dannjjm 2890 6 in in IN cord-023095-4dannjjm 2890 7 cats cat NNS cord-023095-4dannjjm 2890 8 with with IN cord-023095-4dannjjm 2890 9 higher high JJR cord-023095-4dannjjm 2890 10 gingivitis gingivitis NN cord-023095-4dannjjm 2890 11 scores score NNS cord-023095-4dannjjm 2890 12 ( ( -LRB- cord-023095-4dannjjm 2890 13 2 2 CD cord-023095-4dannjjm 2890 14 - - SYM cord-023095-4dannjjm 2890 15 3 3 CD cord-023095-4dannjjm 2890 16 ; ; : cord-023095-4dannjjm 2890 17 chi chi NNP cord-023095-4dannjjm 2890 18 square square NNP cord-023095-4dannjjm 2890 19 : : : cord-023095-4dannjjm 2891 1 p p NN cord-023095-4dannjjm 2891 2 o o NN cord-023095-4dannjjm 2891 3 0.05 0.05 CD cord-023095-4dannjjm 2891 4 ) ) -RRB- cord-023095-4dannjjm 2891 5 , , , cord-023095-4dannjjm 2891 6 while while IN cord-023095-4dannjjm 2891 7 Pasteurella Pasteurella NNP cord-023095-4dannjjm 2891 8 multocida multocida NNP cord-023095-4dannjjm 2891 9 was be VBD cord-023095-4dannjjm 2891 10 found find VBN cord-023095-4dannjjm 2891 11 mostly mostly RB cord-023095-4dannjjm 2891 12 in in IN cord-023095-4dannjjm 2891 13 cats cat NNS cord-023095-4dannjjm 2891 14 with with IN cord-023095-4dannjjm 2891 15 lower low JJR cord-023095-4dannjjm 2891 16 gingivitis gingivitis NN cord-023095-4dannjjm 2891 17 scores score NNS cord-023095-4dannjjm 2891 18 ( ( -LRB- cord-023095-4dannjjm 2891 19 0 0 CD cord-023095-4dannjjm 2891 20 - - SYM cord-023095-4dannjjm 2891 21 1 1 CD cord-023095-4dannjjm 2891 22 ; ; : cord-023095-4dannjjm 2891 23 chi chi NNP cord-023095-4dannjjm 2891 24 square square NNP cord-023095-4dannjjm 2891 25 : : : cord-023095-4dannjjm 2892 1 p p NN cord-023095-4dannjjm 2892 2 o o NN cord-023095-4dannjjm 2892 3 0.05 0.05 CD cord-023095-4dannjjm 2892 4 ) ) -RRB- cord-023095-4dannjjm 2892 5 . . . cord-023095-4dannjjm 2893 1 Antimicrobial antimicrobial JJ cord-023095-4dannjjm 2893 2 sensitivity sensitivity NN cord-023095-4dannjjm 2893 3 testing testing NN cord-023095-4dannjjm 2893 4 indicated indicate VBD cord-023095-4dannjjm 2893 5 that that IN cord-023095-4dannjjm 2893 6 all all DT cord-023095-4dannjjm 2893 7 of of IN cord-023095-4dannjjm 2893 8 the the DT cord-023095-4dannjjm 2893 9 anaerobic anaerobic JJ cord-023095-4dannjjm 2893 10 bacteria bacteria NNS cord-023095-4dannjjm 2893 11 were be VBD cord-023095-4dannjjm 2893 12 sensitive sensitive JJ cord-023095-4dannjjm 2893 13 to to IN cord-023095-4dannjjm 2893 14 clindamycin clindamycin NN cord-023095-4dannjjm 2893 15 , , , cord-023095-4dannjjm 2893 16 chloramphenicol chloramphenicol NNP cord-023095-4dannjjm 2893 17 , , , cord-023095-4dannjjm 2893 18 metronidazole metronidazole NNP cord-023095-4dannjjm 2893 19 , , , cord-023095-4dannjjm 2893 20 cefoxitin cefoxitin NNS cord-023095-4dannjjm 2893 21 , , , cord-023095-4dannjjm 2893 22 or or CC cord-023095-4dannjjm 2893 23 tetracycline tetracycline NN cord-023095-4dannjjm 2893 24 , , , cord-023095-4dannjjm 2893 25 90 90 CD cord-023095-4dannjjm 2893 26 % % NN cord-023095-4dannjjm 2893 27 were be VBD cord-023095-4dannjjm 2893 28 sensitive sensitive JJ cord-023095-4dannjjm 2893 29 to to IN cord-023095-4dannjjm 2893 30 erythromycin erythromycin NN cord-023095-4dannjjm 2893 31 , , , cord-023095-4dannjjm 2893 32 and and CC cord-023095-4dannjjm 2893 33 80 80 CD cord-023095-4dannjjm 2893 34 % % NN cord-023095-4dannjjm 2893 35 were be VBD cord-023095-4dannjjm 2893 36 sensitive sensitive JJ cord-023095-4dannjjm 2893 37 to to IN cord-023095-4dannjjm 2893 38 penicillin penicillin NN cord-023095-4dannjjm 2893 39 . . . cord-023095-4dannjjm 2894 1 The the DT cord-023095-4dannjjm 2894 2 most most RBS cord-023095-4dannjjm 2894 3 abundant abundant JJ cord-023095-4dannjjm 2894 4 aerobic aerobic JJ cord-023095-4dannjjm 2894 5 bacterial bacterial JJ cord-023095-4dannjjm 2894 6 species specie NNS cord-023095-4dannjjm 2894 7 , , , cord-023095-4dannjjm 2894 8 Pasteurella Pasteurella NNP cord-023095-4dannjjm 2894 9 multocida multocida NNP cord-023095-4dannjjm 2894 10 , , , cord-023095-4dannjjm 2894 11 was be VBD cord-023095-4dannjjm 2894 12 sensitive sensitive JJ cord-023095-4dannjjm 2894 13 to to IN cord-023095-4dannjjm 2894 14 cefoxitin cefoxitin NNS cord-023095-4dannjjm 2894 15 in in IN cord-023095-4dannjjm 2894 16 all all DT cord-023095-4dannjjm 2894 17 cases case NNS cord-023095-4dannjjm 2894 18 in in IN cord-023095-4dannjjm 2894 19 which which WDT cord-023095-4dannjjm 2894 20 it -PRON- PRP cord-023095-4dannjjm 2894 21 had have VBD cord-023095-4dannjjm 2894 22 been be VBN cord-023095-4dannjjm 2894 23 cultured culture VBN cord-023095-4dannjjm 2894 24 . . . cord-023095-4dannjjm 2895 1 These these DT cord-023095-4dannjjm 2895 2 results result NNS cord-023095-4dannjjm 2895 3 suggest suggest VBP cord-023095-4dannjjm 2895 4 that that IN cord-023095-4dannjjm 2895 5 anaerobic anaerobic JJ cord-023095-4dannjjm 2895 6 bacteria bacteria NNS cord-023095-4dannjjm 2895 7 may may MD cord-023095-4dannjjm 2895 8 be be VB cord-023095-4dannjjm 2895 9 associated associate VBN cord-023095-4dannjjm 2895 10 in in IN cord-023095-4dannjjm 2895 11 the the DT cord-023095-4dannjjm 2895 12 pathogenesis pathogenesis NN cord-023095-4dannjjm 2895 13 of of IN cord-023095-4dannjjm 2895 14 severe severe JJ cord-023095-4dannjjm 2895 15 gingivitis gingivitis NN cord-023095-4dannjjm 2895 16 . . . cord-023095-4dannjjm 2896 1 These these DT cord-023095-4dannjjm 2896 2 data datum NNS cord-023095-4dannjjm 2896 3 warrant warrant VBP cord-023095-4dannjjm 2896 4 further further JJ cord-023095-4dannjjm 2896 5 studies study NNS cord-023095-4dannjjm 2896 6 of of IN cord-023095-4dannjjm 2896 7 the the DT cord-023095-4dannjjm 2896 8 prophylactic prophylactic JJ cord-023095-4dannjjm 2896 9 use use NN cord-023095-4dannjjm 2896 10 of of IN cord-023095-4dannjjm 2896 11 antibiotics antibiotic NNS cord-023095-4dannjjm 2896 12 in in IN cord-023095-4dannjjm 2896 13 cats cat NNS cord-023095-4dannjjm 2896 14 undergoing undergo VBG cord-023095-4dannjjm 2896 15 dental dental JJ cord-023095-4dannjjm 2896 16 prophylactic prophylactic JJ cord-023095-4dannjjm 2896 17 procedures procedure NNS cord-023095-4dannjjm 2896 18 . . . cord-023095-4dannjjm 2897 1 Inflammatory inflammatory JJ cord-023095-4dannjjm 2897 2 bowel bowel NN cord-023095-4dannjjm 2897 3 disease disease NN cord-023095-4dannjjm 2897 4 is be VBZ cord-023095-4dannjjm 2897 5 the the DT cord-023095-4dannjjm 2897 6 most most RBS cord-023095-4dannjjm 2897 7 common common JJ cord-023095-4dannjjm 2897 8 cause cause NN cord-023095-4dannjjm 2897 9 of of IN cord-023095-4dannjjm 2897 10 vomiting vomiting NN cord-023095-4dannjjm 2897 11 and and CC cord-023095-4dannjjm 2897 12 diarrhea diarrhea NN cord-023095-4dannjjm 2897 13 in in IN cord-023095-4dannjjm 2897 14 dogs dog NNS cord-023095-4dannjjm 2897 15 . . . cord-023095-4dannjjm 2898 1 Although although IN cord-023095-4dannjjm 2898 2 it -PRON- PRP cord-023095-4dannjjm 2898 3 can can MD cord-023095-4dannjjm 2898 4 occur occur VB cord-023095-4dannjjm 2898 5 in in IN cord-023095-4dannjjm 2898 6 any any DT cord-023095-4dannjjm 2898 7 canine canine JJ cord-023095-4dannjjm 2898 8 breed breed NN cord-023095-4dannjjm 2898 9 , , , cord-023095-4dannjjm 2898 10 certain certain JJ cord-023095-4dannjjm 2898 11 breeds breed NNS cord-023095-4dannjjm 2898 12 are be VBP cord-023095-4dannjjm 2898 13 more more RBR cord-023095-4dannjjm 2898 14 susceptible susceptible JJ cord-023095-4dannjjm 2898 15 . . . cord-023095-4dannjjm 2899 1 We -PRON- PRP cord-023095-4dannjjm 2899 2 have have VBP cord-023095-4dannjjm 2899 3 previously previously RB cord-023095-4dannjjm 2899 4 shown show VBN cord-023095-4dannjjm 2899 5 that that IN cord-023095-4dannjjm 2899 6 polymorphisms polymorphism NNS cord-023095-4dannjjm 2899 7 in in IN cord-023095-4dannjjm 2899 8 the the DT cord-023095-4dannjjm 2899 9 TLR4 TLR4 NNP cord-023095-4dannjjm 2899 10 and and CC cord-023095-4dannjjm 2899 11 TLR5 TLR5 NNP cord-023095-4dannjjm 2899 12 gene gene NN cord-023095-4dannjjm 2899 13 are be VBP cord-023095-4dannjjm 2899 14 significantly significantly RB cord-023095-4dannjjm 2899 15 associated associate VBN cord-023095-4dannjjm 2899 16 with with IN cord-023095-4dannjjm 2899 17 inflammatory inflammatory JJ cord-023095-4dannjjm 2899 18 bowel bowel NN cord-023095-4dannjjm 2899 19 disease disease NN cord-023095-4dannjjm 2899 20 ( ( -LRB- cord-023095-4dannjjm 2899 21 IBD IBD NNP cord-023095-4dannjjm 2899 22 ) ) -RRB- cord-023095-4dannjjm 2899 23 in in IN cord-023095-4dannjjm 2899 24 the the DT cord-023095-4dannjjm 2899 25 German german JJ cord-023095-4dannjjm 2899 26 shepherd shepherd NN cord-023095-4dannjjm 2899 27 dog dog NN cord-023095-4dannjjm 2899 28 ( ( -LRB- cord-023095-4dannjjm 2899 29 GSD GSD NNP cord-023095-4dannjjm 2899 30 ) ) -RRB- cord-023095-4dannjjm 2899 31 , , , cord-023095-4dannjjm 2899 32 a a DT cord-023095-4dannjjm 2899 33 breed breed NN cord-023095-4dannjjm 2899 34 at at IN cord-023095-4dannjjm 2899 35 risk risk NN cord-023095-4dannjjm 2899 36 of of IN cord-023095-4dannjjm 2899 37 developing develop VBG cord-023095-4dannjjm 2899 38 this this DT cord-023095-4dannjjm 2899 39 disease disease NN cord-023095-4dannjjm 2899 40 . . . cord-023095-4dannjjm 2900 1 It -PRON- PRP cord-023095-4dannjjm 2900 2 would would MD cord-023095-4dannjjm 2900 3 be be VB cord-023095-4dannjjm 2900 4 useful useful JJ cord-023095-4dannjjm 2900 5 to to TO cord-023095-4dannjjm 2900 6 determine determine VB cord-023095-4dannjjm 2900 7 if if IN cord-023095-4dannjjm 2900 8 these these DT cord-023095-4dannjjm 2900 9 polymorphisms polymorphism NNS cord-023095-4dannjjm 2900 10 are be VBP cord-023095-4dannjjm 2900 11 significant significant JJ cord-023095-4dannjjm 2900 12 in in IN cord-023095-4dannjjm 2900 13 other other JJ cord-023095-4dannjjm 2900 14 canine canine JJ cord-023095-4dannjjm 2900 15 breeds breed NNS cord-023095-4dannjjm 2900 16 as as IN cord-023095-4dannjjm 2900 17 this this DT cord-023095-4dannjjm 2900 18 may may MD cord-023095-4dannjjm 2900 19 allow allow VB cord-023095-4dannjjm 2900 20 the the DT cord-023095-4dannjjm 2900 21 development development NN cord-023095-4dannjjm 2900 22 of of IN cord-023095-4dannjjm 2900 23 novel novel JJ cord-023095-4dannjjm 2900 24 diagnostics diagnostic NNS cord-023095-4dannjjm 2900 25 and and CC cord-023095-4dannjjm 2900 26 therapeutics therapeutic NNS cord-023095-4dannjjm 2900 27 to to TO cord-023095-4dannjjm 2900 28 be be VB cord-023095-4dannjjm 2900 29 applied apply VBN cord-023095-4dannjjm 2900 30 to to IN cord-023095-4dannjjm 2900 31 all all DT cord-023095-4dannjjm 2900 32 canine canine JJ cord-023095-4dannjjm 2900 33 breeds breed NNS cord-023095-4dannjjm 2900 34 with with IN cord-023095-4dannjjm 2900 35 IBD IBD NNP cord-023095-4dannjjm 2900 36 . . . cord-023095-4dannjjm 2901 1 Therefore therefore RB cord-023095-4dannjjm 2901 2 the the DT cord-023095-4dannjjm 2901 3 aim aim NN cord-023095-4dannjjm 2901 4 of of IN cord-023095-4dannjjm 2901 5 this this DT cord-023095-4dannjjm 2901 6 study study NN cord-023095-4dannjjm 2901 7 was be VBD cord-023095-4dannjjm 2901 8 to to TO cord-023095-4dannjjm 2901 9 investigate investigate VB cord-023095-4dannjjm 2901 10 whether whether IN cord-023095-4dannjjm 2901 11 polymorphisms polymorphism NNS cord-023095-4dannjjm 2901 12 in in IN cord-023095-4dannjjm 2901 13 canine canine JJ cord-023095-4dannjjm 2901 14 TLR TLR NNP cord-023095-4dannjjm 2901 15 4 4 CD cord-023095-4dannjjm 2901 16 and and CC cord-023095-4dannjjm 2901 17 TLR TLR NNP cord-023095-4dannjjm 2901 18 5 5 CD cord-023095-4dannjjm 2901 19 genes gene NNS cord-023095-4dannjjm 2901 20 are be VBP cord-023095-4dannjjm 2901 21 associated associate VBN cord-023095-4dannjjm 2901 22 with with IN cord-023095-4dannjjm 2901 23 IBD IBD NNP cord-023095-4dannjjm 2901 24 in in IN cord-023095-4dannjjm 2901 25 other other JJ cord-023095-4dannjjm 2901 26 non non JJ cord-023095-4dannjjm 2901 27 - - JJ cord-023095-4dannjjm 2901 28 GSD gsd JJ cord-023095-4dannjjm 2901 29 canine canine JJ cord-023095-4dannjjm 2901 30 breeds breed NNS cord-023095-4dannjjm 2901 31 . . . cord-023095-4dannjjm 2902 1 Four four CD cord-023095-4dannjjm 2902 2 non non JJ cord-023095-4dannjjm 2902 3 - - JJ cord-023095-4dannjjm 2902 4 synonymous synonymous JJ cord-023095-4dannjjm 2902 5 SNPs snp NNS cord-023095-4dannjjm 2902 6 in in IN cord-023095-4dannjjm 2902 7 the the DT cord-023095-4dannjjm 2902 8 TLR4 TLR4 NNP cord-023095-4dannjjm 2902 9 gene gene NN cord-023095-4dannjjm 2902 10 ; ; : cord-023095-4dannjjm 2902 11 T23C T23C NNP cord-023095-4dannjjm 2902 12 , , , cord-023095-4dannjjm 2902 13 G1039A G1039A NNP cord-023095-4dannjjm 2902 14 , , , cord-023095-4dannjjm 2902 15 A1572 A1572 NNP cord-023095-4dannjjm 2902 16 T T NNP cord-023095-4dannjjm 2902 17 and and CC cord-023095-4dannjjm 2902 18 G1807A G1807A NNP cord-023095-4dannjjm 2902 19 and and CC cord-023095-4dannjjm 2902 20 three three CD cord-023095-4dannjjm 2902 21 non non JJ cord-023095-4dannjjm 2902 22 - - JJ cord-023095-4dannjjm 2902 23 synonymous synonymous JJ cord-023095-4dannjjm 2902 24 SNPs snp NNS cord-023095-4dannjjm 2902 25 in in IN cord-023095-4dannjjm 2902 26 the the DT cord-023095-4dannjjm 2902 27 TLR5 TLR5 NNP cord-023095-4dannjjm 2902 28 gene gene NN cord-023095-4dannjjm 2902 29 ; ; : cord-023095-4dannjjm 2902 30 G22A g22a NN cord-023095-4dannjjm 2902 31 , , , cord-023095-4dannjjm 2902 32 C100 C100 NNP cord-023095-4dannjjm 2902 33 T T NNP cord-023095-4dannjjm 2902 34 and and CC cord-023095-4dannjjm 2902 35 T1844C T1844C NNP cord-023095-4dannjjm 2902 36 previously previously RB cord-023095-4dannjjm 2902 37 identified identify VBN cord-023095-4dannjjm 2902 38 in in IN cord-023095-4dannjjm 2902 39 a a DT cord-023095-4dannjjm 2902 40 mutational mutational JJ cord-023095-4dannjjm 2902 41 analysis analysis NN cord-023095-4dannjjm 2902 42 in in IN cord-023095-4dannjjm 2902 43 GSDs gsds NN cord-023095-4dannjjm 2902 44 with with IN cord-023095-4dannjjm 2902 45 IBD IBD NNP cord-023095-4dannjjm 2902 46 were be VBD cord-023095-4dannjjm 2902 47 evaluated evaluate VBN cord-023095-4dannjjm 2902 48 in in IN cord-023095-4dannjjm 2902 49 a a DT cord-023095-4dannjjm 2902 50 case case NN cord-023095-4dannjjm 2902 51 - - HYPH cord-023095-4dannjjm 2902 52 control control NN cord-023095-4dannjjm 2902 53 study study NN cord-023095-4dannjjm 2902 54 using use VBG cord-023095-4dannjjm 2902 55 a a DT cord-023095-4dannjjm 2902 56 SNaPSHOT SNaPSHOT NNP cord-023095-4dannjjm 2902 57 multiplex multiplex NN cord-023095-4dannjjm 2902 58 reaction reaction NN cord-023095-4dannjjm 2902 59 . . . cord-023095-4dannjjm 2903 1 Sequencing sequence VBG cord-023095-4dannjjm 2903 2 information information NN cord-023095-4dannjjm 2903 3 from from IN cord-023095-4dannjjm 2903 4 85 85 CD cord-023095-4dannjjm 2903 5 unrelated unrelated JJ cord-023095-4dannjjm 2903 6 dogs dog NNS cord-023095-4dannjjm 2903 7 with with IN cord-023095-4dannjjm 2903 8 IBD IBD NNP cord-023095-4dannjjm 2903 9 consisting consist VBG cord-023095-4dannjjm 2903 10 of of IN cord-023095-4dannjjm 2903 11 38 38 CD cord-023095-4dannjjm 2903 12 different different JJ cord-023095-4dannjjm 2903 13 non non JJ cord-023095-4dannjjm 2903 14 - - JJ cord-023095-4dannjjm 2903 15 GSD gsd JJ cord-023095-4dannjjm 2903 16 breeds breed NNS cord-023095-4dannjjm 2903 17 from from IN cord-023095-4dannjjm 2903 18 the the DT cord-023095-4dannjjm 2903 19 UK UK NNP cord-023095-4dannjjm 2903 20 were be VBD cord-023095-4dannjjm 2903 21 compared compare VBN cord-023095-4dannjjm 2903 22 to to IN cord-023095-4dannjjm 2903 23 a a DT cord-023095-4dannjjm 2903 24 breed breed NN cord-023095-4dannjjm 2903 25 - - HYPH cord-023095-4dannjjm 2903 26 matched match VBN cord-023095-4dannjjm 2903 27 control control NN cord-023095-4dannjjm 2903 28 group group NN cord-023095-4dannjjm 2903 29 consisting consist VBG cord-023095-4dannjjm 2903 30 of of IN cord-023095-4dannjjm 2903 31 162 162 CD cord-023095-4dannjjm 2903 32 unrelated unrelated JJ cord-023095-4dannjjm 2903 33 dogs dog NNS cord-023095-4dannjjm 2903 34 from from IN cord-023095-4dannjjm 2903 35 patients patient NNS cord-023095-4dannjjm 2903 36 treated treat VBN cord-023095-4dannjjm 2903 37 for for IN cord-023095-4dannjjm 2903 38 noninflammatory noninflammatory JJ cord-023095-4dannjjm 2903 39 disease disease NN cord-023095-4dannjjm 2903 40 at at IN cord-023095-4dannjjm 2903 41 the the DT cord-023095-4dannjjm 2903 42 Royal Royal NNP cord-023095-4dannjjm 2903 43 Veterinary Veterinary NNP cord-023095-4dannjjm 2903 44 College College NNP cord-023095-4dannjjm 2903 45 , , , cord-023095-4dannjjm 2903 46 London London NNP cord-023095-4dannjjm 2903 47 , , , cord-023095-4dannjjm 2903 48 UK UK NNP cord-023095-4dannjjm 2903 49 . . . cord-023095-4dannjjm 2904 1 As as IN cord-023095-4dannjjm 2904 2 in in IN cord-023095-4dannjjm 2904 3 the the DT cord-023095-4dannjjm 2904 4 GSD GSD NNP cord-023095-4dannjjm 2904 5 IBD IBD NNP cord-023095-4dannjjm 2904 6 population population NN cord-023095-4dannjjm 2904 7 the the DT cord-023095-4dannjjm 2904 8 two two CD cord-023095-4dannjjm 2904 9 TLR5 TLR5 NNP cord-023095-4dannjjm 2904 10 SNPs SNPs NNPS cord-023095-4dannjjm 2904 11 ; ; : cord-023095-4dannjjm 2904 12 C100 C100 NNP cord-023095-4dannjjm 2904 13 T T NNP cord-023095-4dannjjm 2904 14 and and CC cord-023095-4dannjjm 2904 15 T1844C T1844C NNP cord-023095-4dannjjm 2904 16 were be VBD cord-023095-4dannjjm 2904 17 found find VBN cord-023095-4dannjjm 2904 18 to to TO cord-023095-4dannjjm 2904 19 be be VB cord-023095-4dannjjm 2904 20 significantly significantly RB cord-023095-4dannjjm 2904 21 protective protective JJ cord-023095-4dannjjm 2904 22 for for IN cord-023095-4dannjjm 2904 23 IBD IBD NNP cord-023095-4dannjjm 2904 24 in in IN cord-023095-4dannjjm 2904 25 other other JJ cord-023095-4dannjjm 2904 26 breeds breed NNS cord-023095-4dannjjm 2904 27 included include VBN cord-023095-4dannjjm 2904 28 in in IN cord-023095-4dannjjm 2904 29 this this DT cord-023095-4dannjjm 2904 30 study study NN cord-023095-4dannjjm 2904 31 ( ( -LRB- cord-023095-4dannjjm 2904 32 p p NN cord-023095-4dannjjm 2904 33 5 5 CD cord-023095-4dannjjm 2904 34 0.023 0.023 CD cord-023095-4dannjjm 2904 35 and and CC cord-023095-4dannjjm 2904 36 p p NN cord-023095-4dannjjm 2904 37 5 5 CD cord-023095-4dannjjm 2904 38 0.0195 0.0195 CD cord-023095-4dannjjm 2904 39 respectively respectively RB cord-023095-4dannjjm 2904 40 ) ) -RRB- cord-023095-4dannjjm 2904 41 . . . cord-023095-4dannjjm 2905 1 This this DT cord-023095-4dannjjm 2905 2 study study NN cord-023095-4dannjjm 2905 3 confirms confirm VBZ cord-023095-4dannjjm 2905 4 the the DT cord-023095-4dannjjm 2905 5 protective protective JJ cord-023095-4dannjjm 2905 6 effects effect NNS cord-023095-4dannjjm 2905 7 of of IN cord-023095-4dannjjm 2905 8 the the DT cord-023095-4dannjjm 2905 9 two two CD cord-023095-4dannjjm 2905 10 TLR5 TLR5 NNP cord-023095-4dannjjm 2905 11 SNPs SNPs NNPS cord-023095-4dannjjm 2905 12 ( ( -LRB- cord-023095-4dannjjm 2905 13 C100 C100 NNP cord-023095-4dannjjm 2905 14 T T NNP cord-023095-4dannjjm 2905 15 and and CC cord-023095-4dannjjm 2905 16 T1884C T1884C NNP cord-023095-4dannjjm 2905 17 ) ) -RRB- cord-023095-4dannjjm 2905 18 in in IN cord-023095-4dannjjm 2905 19 other other JJ cord-023095-4dannjjm 2905 20 canine canine JJ cord-023095-4dannjjm 2905 21 breeds breed NNS cord-023095-4dannjjm 2905 22 with with IN cord-023095-4dannjjm 2905 23 IBD IBD NNP cord-023095-4dannjjm 2905 24 . . . cord-023095-4dannjjm 2906 1 This this DT cord-023095-4dannjjm 2906 2 highlights highlight VBZ cord-023095-4dannjjm 2906 3 the the DT cord-023095-4dannjjm 2906 4 importance importance NN cord-023095-4dannjjm 2906 5 of of IN cord-023095-4dannjjm 2906 6 TLR5 TLR5 NNP cord-023095-4dannjjm 2906 7 in in IN cord-023095-4dannjjm 2906 8 the the DT cord-023095-4dannjjm 2906 9 pathogenesis pathogenesis NN cord-023095-4dannjjm 2906 10 of of IN cord-023095-4dannjjm 2906 11 canine canine JJ cord-023095-4dannjjm 2906 12 IBD IBD NNP cord-023095-4dannjjm 2906 13 and and CC cord-023095-4dannjjm 2906 14 may may MD cord-023095-4dannjjm 2906 15 represent represent VB cord-023095-4dannjjm 2906 16 common common JJ cord-023095-4dannjjm 2906 17 pathological pathological JJ cord-023095-4dannjjm 2906 18 pathways pathway NNS cord-023095-4dannjjm 2906 19 of of IN cord-023095-4dannjjm 2906 20 IBD IBD NNP cord-023095-4dannjjm 2906 21 in in IN cord-023095-4dannjjm 2906 22 different different JJ cord-023095-4dannjjm 2906 23 canine canine JJ cord-023095-4dannjjm 2906 24 breeds breed NNS cord-023095-4dannjjm 2906 25 due due JJ cord-023095-4dannjjm 2906 26 to to IN cord-023095-4dannjjm 2906 27 the the DT cord-023095-4dannjjm 2906 28 high high JJ cord-023095-4dannjjm 2906 29 degree degree NN cord-023095-4dannjjm 2906 30 of of IN cord-023095-4dannjjm 2906 31 haplotype haplotype NN cord-023095-4dannjjm 2906 32 sharing sharing NN cord-023095-4dannjjm 2906 33 seen see VBN cord-023095-4dannjjm 2906 34 among among IN cord-023095-4dannjjm 2906 35 breeds breed NNS cord-023095-4dannjjm 2906 36 . . . cord-023095-4dannjjm 2907 1 This this DT cord-023095-4dannjjm 2907 2 may may MD cord-023095-4dannjjm 2907 3 allow allow VB cord-023095-4dannjjm 2907 4 for for IN cord-023095-4dannjjm 2907 5 the the DT cord-023095-4dannjjm 2907 6 future future JJ cord-023095-4dannjjm 2907 7 expansion expansion NN cord-023095-4dannjjm 2907 8 of of IN cord-023095-4dannjjm 2907 9 novel novel JJ cord-023095-4dannjjm 2907 10 diagnostics diagnostic NNS cord-023095-4dannjjm 2907 11 and and CC cord-023095-4dannjjm 2907 12 therapeutics therapeutic NNS cord-023095-4dannjjm 2907 13 to to TO cord-023095-4dannjjm 2907 14 be be VB cord-023095-4dannjjm 2907 15 applied apply VBN cord-023095-4dannjjm 2907 16 to to IN cord-023095-4dannjjm 2907 17 all all DT cord-023095-4dannjjm 2907 18 canine canine JJ cord-023095-4dannjjm 2907 19 breeds breed NNS cord-023095-4dannjjm 2907 20 with with IN cord-023095-4dannjjm 2907 21 IBD IBD NNP cord-023095-4dannjjm 2907 22 . . . cord-023095-4dannjjm 2908 1 Further further JJ cord-023095-4dannjjm 2908 2 functional functional JJ cord-023095-4dannjjm 2908 3 studies study NNS cord-023095-4dannjjm 2908 4 looking look VBG cord-023095-4dannjjm 2908 5 at at IN cord-023095-4dannjjm 2908 6 the the DT cord-023095-4dannjjm 2908 7 role role NN cord-023095-4dannjjm 2908 8 of of IN cord-023095-4dannjjm 2908 9 TLR5 TLR5 NNP cord-023095-4dannjjm 2908 10 in in IN cord-023095-4dannjjm 2908 11 the the DT cord-023095-4dannjjm 2908 12 pathogenesis pathogenesis NN cord-023095-4dannjjm 2908 13 of of IN cord-023095-4dannjjm 2908 14 canine canine JJ cord-023095-4dannjjm 2908 15 IBD IBD NNP cord-023095-4dannjjm 2908 16 are be VBP cord-023095-4dannjjm 2908 17 needed need VBN cord-023095-4dannjjm 2908 18 to to TO cord-023095-4dannjjm 2908 19 confirm confirm VB cord-023095-4dannjjm 2908 20 these these DT cord-023095-4dannjjm 2908 21 findings finding NNS cord-023095-4dannjjm 2908 22 . . . cord-023095-4dannjjm 2909 1 Toll toll NN cord-023095-4dannjjm 2909 2 - - HYPH cord-023095-4dannjjm 2909 3 like like JJ cord-023095-4dannjjm 2909 4 receptor receptor NN cord-023095-4dannjjm 2909 5 5 5 CD cord-023095-4dannjjm 2910 1 ( ( -LRB- cord-023095-4dannjjm 2910 2 TLR5 TLR5 NNP cord-023095-4dannjjm 2910 3 ) ) -RRB- cord-023095-4dannjjm 2910 4 is be VBZ cord-023095-4dannjjm 2910 5 an an DT cord-023095-4dannjjm 2910 6 extracellular extracellular JJ cord-023095-4dannjjm 2910 7 pattern pattern NN cord-023095-4dannjjm 2910 8 recognition recognition NN cord-023095-4dannjjm 2910 9 receptor receptor NN cord-023095-4dannjjm 2910 10 belonging belong VBG cord-023095-4dannjjm 2910 11 to to IN cord-023095-4dannjjm 2910 12 the the DT cord-023095-4dannjjm 2910 13 innate innate JJ cord-023095-4dannjjm 2910 14 immune immune JJ cord-023095-4dannjjm 2910 15 system system NN cord-023095-4dannjjm 2910 16 . . . cord-023095-4dannjjm 2911 1 We -PRON- PRP cord-023095-4dannjjm 2911 2 have have VBP cord-023095-4dannjjm 2911 3 recently recently RB cord-023095-4dannjjm 2911 4 shown show VBN cord-023095-4dannjjm 2911 5 that that IN cord-023095-4dannjjm 2911 6 three three CD cord-023095-4dannjjm 2911 7 non non JJ cord-023095-4dannjjm 2911 8 - - JJ cord-023095-4dannjjm 2911 9 synonymous synonymous JJ cord-023095-4dannjjm 2911 10 single single JJ cord-023095-4dannjjm 2911 11 nucleotide nucleotide JJ cord-023095-4dannjjm 2911 12 polymorphisms polymorphism NNS cord-023095-4dannjjm 2911 13 ( ( -LRB- cord-023095-4dannjjm 2911 14 SNPs SNPs NNP cord-023095-4dannjjm 2911 15 ) ) -RRB- cord-023095-4dannjjm 2911 16 in in IN cord-023095-4dannjjm 2911 17 the the DT cord-023095-4dannjjm 2911 18 TLR5 TLR5 NNP cord-023095-4dannjjm 2911 19 gene gene NN cord-023095-4dannjjm 2911 20 ( ( -LRB- cord-023095-4dannjjm 2911 21 G22A g22a NN cord-023095-4dannjjm 2911 22 , , , cord-023095-4dannjjm 2911 23 C100 C100 NNP cord-023095-4dannjjm 2911 24 T T NNP cord-023095-4dannjjm 2911 25 and and CC cord-023095-4dannjjm 2911 26 T1844C T1844C NNP cord-023095-4dannjjm 2911 27 ) ) -RRB- cord-023095-4dannjjm 2911 28 are be VBP cord-023095-4dannjjm 2911 29 significantly significantly RB cord-023095-4dannjjm 2911 30 associated associate VBN cord-023095-4dannjjm 2911 31 with with IN cord-023095-4dannjjm 2911 32 inflammatory inflammatory JJ cord-023095-4dannjjm 2911 33 bowel bowel NN cord-023095-4dannjjm 2911 34 disease disease NN cord-023095-4dannjjm 2911 35 ( ( -LRB- cord-023095-4dannjjm 2911 36 IBD IBD NNP cord-023095-4dannjjm 2911 37 ) ) -RRB- cord-023095-4dannjjm 2911 38 in in IN cord-023095-4dannjjm 2911 39 German german JJ cord-023095-4dannjjm 2911 40 shepherd shepherd NN cord-023095-4dannjjm 2911 41 dogs dog NNS cord-023095-4dannjjm 2911 42 . . . cord-023095-4dannjjm 2912 1 In in IN cord-023095-4dannjjm 2912 2 addition addition NN cord-023095-4dannjjm 2912 3 , , , cord-023095-4dannjjm 2912 4 we -PRON- PRP cord-023095-4dannjjm 2912 5 confirmed confirm VBD cord-023095-4dannjjm 2912 6 that that IN cord-023095-4dannjjm 2912 7 two two CD cord-023095-4dannjjm 2912 8 of of IN cord-023095-4dannjjm 2912 9 these these DT cord-023095-4dannjjm 2912 10 TLR5 TLR5 NNP cord-023095-4dannjjm 2912 11 SNPs SNPs NNPS cord-023095-4dannjjm 2912 12 ( ( -LRB- cord-023095-4dannjjm 2912 13 C100 C100 NNP cord-023095-4dannjjm 2912 14 T T NNP cord-023095-4dannjjm 2912 15 and and CC cord-023095-4dannjjm 2912 16 T1844C T1844C NNP cord-023095-4dannjjm 2912 17 ) ) -RRB- cord-023095-4dannjjm 2912 18 were be VBD cord-023095-4dannjjm 2912 19 significantly significantly RB cord-023095-4dannjjm 2912 20 associated associate VBN cord-023095-4dannjjm 2912 21 with with IN cord-023095-4dannjjm 2912 22 IBD IBD NNP cord-023095-4dannjjm 2912 23 in in IN cord-023095-4dannjjm 2912 24 a a DT cord-023095-4dannjjm 2912 25 population population NN cord-023095-4dannjjm 2912 26 consisting consist VBG cord-023095-4dannjjm 2912 27 of of IN cord-023095-4dannjjm 2912 28 38 38 CD cord-023095-4dannjjm 2912 29 different different JJ cord-023095-4dannjjm 2912 30 dog dog NN cord-023095-4dannjjm 2912 31 breeds breed NNS cord-023095-4dannjjm 2912 32 . . . cord-023095-4dannjjm 2913 1 In in IN cord-023095-4dannjjm 2913 2 order order NN cord-023095-4dannjjm 2913 3 to to TO cord-023095-4dannjjm 2913 4 determine determine VB cord-023095-4dannjjm 2913 5 if if IN cord-023095-4dannjjm 2913 6 other other JJ cord-023095-4dannjjm 2913 7 novel novel NN cord-023095-4dannjjm 2913 8 SNPs snp NNS cord-023095-4dannjjm 2913 9 exist exist VBP cord-023095-4dannjjm 2913 10 in in IN cord-023095-4dannjjm 2913 11 the the DT cord-023095-4dannjjm 2913 12 TLR5 TLR5 NNP cord-023095-4dannjjm 2913 13 gene gene NN cord-023095-4dannjjm 2913 14 in in IN cord-023095-4dannjjm 2913 15 addition addition NN cord-023095-4dannjjm 2913 16 to to IN cord-023095-4dannjjm 2913 17 the the DT cord-023095-4dannjjm 2913 18 ones one NNS cord-023095-4dannjjm 2913 19 identified identify VBN cord-023095-4dannjjm 2913 20 in in IN cord-023095-4dannjjm 2913 21 the the DT cord-023095-4dannjjm 2913 22 GSD GSD NNP cord-023095-4dannjjm 2913 23 population population NN cord-023095-4dannjjm 2913 24 , , , cord-023095-4dannjjm 2913 25 mutational mutational JJ cord-023095-4dannjjm 2913 26 analysis analysis NN cord-023095-4dannjjm 2913 27 was be VBD cord-023095-4dannjjm 2913 28 carried carry VBN cord-023095-4dannjjm 2913 29 out out RP cord-023095-4dannjjm 2913 30 in in IN cord-023095-4dannjjm 2913 31 seven seven CD cord-023095-4dannjjm 2913 32 Boxer Boxer NNP cord-023095-4dannjjm 2913 33 dogs dog NNS cord-023095-4dannjjm 2913 34 with with IN cord-023095-4dannjjm 2913 35 IBD IBD NNP cord-023095-4dannjjm 2913 36 . . . cord-023095-4dannjjm 2914 1 Polymerase polymerase NN cord-023095-4dannjjm 2914 2 chain chain NN cord-023095-4dannjjm 2914 3 reaction reaction NN cord-023095-4dannjjm 2914 4 was be VBD cord-023095-4dannjjm 2914 5 carried carry VBN cord-023095-4dannjjm 2914 6 out out RP cord-023095-4dannjjm 2914 7 to to TO cord-023095-4dannjjm 2914 8 amplify amplify VB cord-023095-4dannjjm 2914 9 the the DT cord-023095-4dannjjm 2914 10 TLR5 TLR5 NNP cord-023095-4dannjjm 2914 11 coding code VBG cord-023095-4dannjjm 2914 12 region region NN cord-023095-4dannjjm 2914 13 in in IN cord-023095-4dannjjm 2914 14 the the DT cord-023095-4dannjjm 2914 15 seven seven CD cord-023095-4dannjjm 2914 16 dogs dog NNS cord-023095-4dannjjm 2914 17 with with IN cord-023095-4dannjjm 2914 18 IBD IBD NNP cord-023095-4dannjjm 2914 19 . . . cord-023095-4dannjjm 2915 1 Sequencing sequencing NN cord-023095-4dannjjm 2915 2 was be VBD cord-023095-4dannjjm 2915 3 carried carry VBN cord-023095-4dannjjm 2915 4 out out RP cord-023095-4dannjjm 2915 5 using use VBG cord-023095-4dannjjm 2915 6 sequence sequence NN cord-023095-4dannjjm 2915 7 based base VBN cord-023095-4dannjjm 2915 8 typing typing NN cord-023095-4dannjjm 2915 9 with with IN cord-023095-4dannjjm 2915 10 the the DT cord-023095-4dannjjm 2915 11 ABI ABI NNP cord-023095-4dannjjm 2915 12 Prism Prism NNP cord-023095-4dannjjm 2915 13 Sequencing Sequencing NNP cord-023095-4dannjjm 2915 14 Kit kit NN cord-023095-4dannjjm 2915 15 ( ( -LRB- cord-023095-4dannjjm 2915 16 Applied Applied NNP cord-023095-4dannjjm 2915 17 Biosystems Biosystems NNP cord-023095-4dannjjm 2915 18 , , , cord-023095-4dannjjm 2915 19 UK UK NNP cord-023095-4dannjjm 2915 20 ) ) -RRB- cord-023095-4dannjjm 2915 21 and and CC cord-023095-4dannjjm 2915 22 analyzed analyze VBD cord-023095-4dannjjm 2915 23 using use VBG cord-023095-4dannjjm 2915 24 an an DT cord-023095-4dannjjm 2915 25 ABI3100 ABI3100 NNP cord-023095-4dannjjm 2915 26 automated automate VBN cord-023095-4dannjjm 2915 27 sequencer sequencer NN cord-023095-4dannjjm 2915 28 ( ( -LRB- cord-023095-4dannjjm 2915 29 PE PE NNP cord-023095-4dannjjm 2915 30 Applied Applied NNP cord-023095-4dannjjm 2915 31 Biosystems Biosystems NNP cord-023095-4dannjjm 2915 32 ) ) -RRB- cord-023095-4dannjjm 2915 33 . . . cord-023095-4dannjjm 2916 1 Sequencing sequence VBG cord-023095-4dannjjm 2916 2 information information NN cord-023095-4dannjjm 2916 3 from from IN cord-023095-4dannjjm 2916 4 seven seven CD cord-023095-4dannjjm 2916 5 Boxer Boxer NNP cord-023095-4dannjjm 2916 6 dogs dog NNS cord-023095-4dannjjm 2916 7 with with IN cord-023095-4dannjjm 2916 8 IBD IBD NNP cord-023095-4dannjjm 2916 9 from from IN cord-023095-4dannjjm 2916 10 the the DT cord-023095-4dannjjm 2916 11 UK UK NNP cord-023095-4dannjjm 2916 12 were be VBD cord-023095-4dannjjm 2916 13 compared compare VBN cord-023095-4dannjjm 2916 14 to to IN cord-023095-4dannjjm 2916 15 the the DT cord-023095-4dannjjm 2916 16 reference reference NN cord-023095-4dannjjm 2916 17 sequence sequence NN cord-023095-4dannjjm 2916 18 published publish VBN cord-023095-4dannjjm 2916 19 on on IN cord-023095-4dannjjm 2916 20 the the DT cord-023095-4dannjjm 2916 21 Ensemble Ensemble NNP cord-023095-4dannjjm 2916 22 webserver webserver NN cord-023095-4dannjjm 2916 23 ( ( -LRB- cord-023095-4dannjjm 2916 24 www www NN cord-023095-4dannjjm 2916 25 . . . cord-023095-4dannjjm 2916 26 ensembl.org/Canis_familiaris ensembl.org/Canis_familiaris NNP cord-023095-4dannjjm 2916 27 ) ) -RRB- cord-023095-4dannjjm 2916 28 . . . cord-023095-4dannjjm 2917 1 In in IN cord-023095-4dannjjm 2917 2 addition addition NN cord-023095-4dannjjm 2917 3 to to IN cord-023095-4dannjjm 2917 4 the the DT cord-023095-4dannjjm 2917 5 three three CD cord-023095-4dannjjm 2917 6 SNPs SNPs NNPS cord-023095-4dannjjm 2917 7 identified identify VBN cord-023095-4dannjjm 2917 8 previously previously RB cord-023095-4dannjjm 2917 9 in in IN cord-023095-4dannjjm 2917 10 the the DT cord-023095-4dannjjm 2917 11 TLR5 TLR5 NNP cord-023095-4dannjjm 2917 12 gene gene NN cord-023095-4dannjjm 2917 13 , , , cord-023095-4dannjjm 2917 14 a a DT cord-023095-4dannjjm 2917 15 novel novel JJ cord-023095-4dannjjm 2917 16 non non JJ cord-023095-4dannjjm 2917 17 - - JJ cord-023095-4dannjjm 2917 18 synonymous synonymous JJ cord-023095-4dannjjm 2917 19 SNP SNP NNP cord-023095-4dannjjm 2917 20 ; ; : cord-023095-4dannjjm 2917 21 T443C T443C NNP cord-023095-4dannjjm 2917 22 was be VBD cord-023095-4dannjjm 2917 23 identified identify VBN cord-023095-4dannjjm 2917 24 in in IN cord-023095-4dannjjm 2917 25 the the DT cord-023095-4dannjjm 2917 26 Boxer Boxer NNP cord-023095-4dannjjm 2917 27 dog dog NN cord-023095-4dannjjm 2917 28 population population NN cord-023095-4dannjjm 2917 29 with with IN cord-023095-4dannjjm 2917 30 IBD IBD NNP cord-023095-4dannjjm 2917 31 . . . cord-023095-4dannjjm 2918 1 This this DT cord-023095-4dannjjm 2918 2 SNP SNP NNP cord-023095-4dannjjm 2918 3 has have VBZ cord-023095-4dannjjm 2918 4 never never RB cord-023095-4dannjjm 2918 5 been be VBN cord-023095-4dannjjm 2918 6 reported report VBN cord-023095-4dannjjm 2918 7 before before RB cord-023095-4dannjjm 2918 8 and and CC cord-023095-4dannjjm 2918 9 was be VBD cord-023095-4dannjjm 2918 10 present present JJ cord-023095-4dannjjm 2918 11 as as IN cord-023095-4dannjjm 2918 12 the the DT cord-023095-4dannjjm 2918 13 homozygote homozygote NNP cord-023095-4dannjjm 2918 14 genotype genotype NNP cord-023095-4dannjjm 2918 15 in in IN cord-023095-4dannjjm 2918 16 three three CD cord-023095-4dannjjm 2918 17 dogs dog NNS cord-023095-4dannjjm 2918 18 with with IN cord-023095-4dannjjm 2918 19 IBD IBD NNP cord-023095-4dannjjm 2918 20 and and CC cord-023095-4dannjjm 2918 21 in in IN cord-023095-4dannjjm 2918 22 one one CD cord-023095-4dannjjm 2918 23 dog dog NN cord-023095-4dannjjm 2918 24 as as IN cord-023095-4dannjjm 2918 25 the the DT cord-023095-4dannjjm 2918 26 heterozygote heterozygote NN cord-023095-4dannjjm 2918 27 genotype genotype NN cord-023095-4dannjjm 2918 28 . . . cord-023095-4dannjjm 2919 1 Using use VBG cord-023095-4dannjjm 2919 2 the the DT cord-023095-4dannjjm 2919 3 Simple Simple NNP cord-023095-4dannjjm 2919 4 modular modular JJ cord-023095-4dannjjm 2919 5 architecture architecture NN cord-023095-4dannjjm 2919 6 research research NN cord-023095-4dannjjm 2919 7 tool tool NN cord-023095-4dannjjm 2919 8 ( ( -LRB- cord-023095-4dannjjm 2919 9 SMART SMART NNP cord-023095-4dannjjm 2919 10 ) ) -RRB- cord-023095-4dannjjm 2919 11 web web NN cord-023095-4dannjjm 2919 12 server server NN cord-023095-4dannjjm 2919 13 ( ( -LRB- cord-023095-4dannjjm 2919 14 http:// http:// NNP cord-023095-4dannjjm 2919 15 smart.embl.de/ smart.embl.de/ NNP cord-023095-4dannjjm 2919 16 ) ) -RRB- cord-023095-4dannjjm 2920 1 we -PRON- PRP cord-023095-4dannjjm 2920 2 were be VBD cord-023095-4dannjjm 2920 3 able able JJ cord-023095-4dannjjm 2920 4 to to TO cord-023095-4dannjjm 2920 5 map map VB cord-023095-4dannjjm 2920 6 the the DT cord-023095-4dannjjm 2920 7 T443C T443C VBN cord-023095-4dannjjm 2920 8 SNP SNP NNP cord-023095-4dannjjm 2920 9 to to IN cord-023095-4dannjjm 2920 10 the the DT cord-023095-4dannjjm 2920 11 leucine leucine NN cord-023095-4dannjjm 2920 12 rich rich JJ cord-023095-4dannjjm 2920 13 repeat repeat NN cord-023095-4dannjjm 2920 14 domain domain NN cord-023095-4dannjjm 2920 15 of of IN cord-023095-4dannjjm 2920 16 the the DT cord-023095-4dannjjm 2920 17 TLR5 TLR5 NNP cord-023095-4dannjjm 2920 18 protein protein NN cord-023095-4dannjjm 2920 19 . . . cord-023095-4dannjjm 2921 1 The the DT cord-023095-4dannjjm 2921 2 leucine leucine NN cord-023095-4dannjjm 2921 3 rich rich JJ cord-023095-4dannjjm 2921 4 repeat repeat NN cord-023095-4dannjjm 2921 5 domain domain NN cord-023095-4dannjjm 2921 6 is be VBZ cord-023095-4dannjjm 2921 7 involved involve VBN cord-023095-4dannjjm 2921 8 with with IN cord-023095-4dannjjm 2921 9 ligand ligand NN cord-023095-4dannjjm 2921 10 binding binding NN cord-023095-4dannjjm 2921 11 and and CC cord-023095-4dannjjm 2921 12 therefore therefore RB cord-023095-4dannjjm 2921 13 a a DT cord-023095-4dannjjm 2921 14 change change NN cord-023095-4dannjjm 2921 15 in in IN cord-023095-4dannjjm 2921 16 the the DT cord-023095-4dannjjm 2921 17 amino amino NN cord-023095-4dannjjm 2921 18 acid acid NN cord-023095-4dannjjm 2921 19 in in IN cord-023095-4dannjjm 2921 20 this this DT cord-023095-4dannjjm 2921 21 region region NN cord-023095-4dannjjm 2921 22 may may MD cord-023095-4dannjjm 2921 23 affect affect VB cord-023095-4dannjjm 2921 24 function function NN cord-023095-4dannjjm 2921 25 , , , cord-023095-4dannjjm 2921 26 especially especially RB cord-023095-4dannjjm 2921 27 as as IN cord-023095-4dannjjm 2921 28 the the DT cord-023095-4dannjjm 2921 29 T443C T443C NNP cord-023095-4dannjjm 2921 30 SNP SNP NNP cord-023095-4dannjjm 2921 31 results result VBZ cord-023095-4dannjjm 2921 32 in in IN cord-023095-4dannjjm 2921 33 a a DT cord-023095-4dannjjm 2921 34 change change NN cord-023095-4dannjjm 2921 35 in in IN cord-023095-4dannjjm 2921 36 the the DT cord-023095-4dannjjm 2921 37 amino amino NN cord-023095-4dannjjm 2921 38 acid acid NN cord-023095-4dannjjm 2921 39 from from IN cord-023095-4dannjjm 2921 40 non non JJ cord-023095-4dannjjm 2921 41 - - JJ cord-023095-4dannjjm 2921 42 polar polar JJ cord-023095-4dannjjm 2921 43 to to TO cord-023095-4dannjjm 2921 44 polar polar JJ cord-023095-4dannjjm 2921 45 . . . cord-023095-4dannjjm 2922 1 Our -PRON- PRP$ cord-023095-4dannjjm 2922 2 study study NN cord-023095-4dannjjm 2922 3 further further RB cord-023095-4dannjjm 2922 4 confirms confirm VBZ cord-023095-4dannjjm 2922 5 the the DT cord-023095-4dannjjm 2922 6 role role NN cord-023095-4dannjjm 2922 7 of of IN cord-023095-4dannjjm 2922 8 TLR5 TLR5 NNP cord-023095-4dannjjm 2922 9 in in IN cord-023095-4dannjjm 2922 10 the the DT cord-023095-4dannjjm 2922 11 pathogenesis pathogenesis NN cord-023095-4dannjjm 2922 12 of of IN cord-023095-4dannjjm 2922 13 canine canine JJ cord-023095-4dannjjm 2922 14 IBD IBD NNP cord-023095-4dannjjm 2922 15 . . . cord-023095-4dannjjm 2923 1 Our -PRON- PRP$ cord-023095-4dannjjm 2923 2 results result NNS cord-023095-4dannjjm 2923 3 suggest suggest VBP cord-023095-4dannjjm 2923 4 that that IN cord-023095-4dannjjm 2923 5 in in IN cord-023095-4dannjjm 2923 6 addition addition NN cord-023095-4dannjjm 2923 7 to to IN cord-023095-4dannjjm 2923 8 shared share VBN cord-023095-4dannjjm 2923 9 risk risk NN cord-023095-4dannjjm 2923 10 polymorphisms polymorphism NNS cord-023095-4dannjjm 2923 11 amongst amongst IN cord-023095-4dannjjm 2923 12 breeds breed NNS cord-023095-4dannjjm 2923 13 , , , cord-023095-4dannjjm 2923 14 individual individual JJ cord-023095-4dannjjm 2923 15 breeds breed NNS cord-023095-4dannjjm 2923 16 may may MD cord-023095-4dannjjm 2923 17 harbor harbor VB cord-023095-4dannjjm 2923 18 unique unique JJ cord-023095-4dannjjm 2923 19 SNPs snp NNS cord-023095-4dannjjm 2923 20 arising arise VBG cord-023095-4dannjjm 2923 21 after after IN cord-023095-4dannjjm 2923 22 breed breed NN cord-023095-4dannjjm 2923 23 formation formation NN cord-023095-4dannjjm 2923 24 which which WDT cord-023095-4dannjjm 2923 25 may may MD cord-023095-4dannjjm 2923 26 further further RB cord-023095-4dannjjm 2923 27 affect affect VB cord-023095-4dannjjm 2923 28 their -PRON- PRP$ cord-023095-4dannjjm 2923 29 susceptibility susceptibility NN cord-023095-4dannjjm 2923 30 to to IN cord-023095-4dannjjm 2923 31 this this DT cord-023095-4dannjjm 2923 32 disease disease NN cord-023095-4dannjjm 2923 33 . . . cord-023095-4dannjjm 2924 1 However however RB cord-023095-4dannjjm 2924 2 , , , cord-023095-4dannjjm 2924 3 a a DT cord-023095-4dannjjm 2924 4 case case NN cord-023095-4dannjjm 2924 5 - - HYPH cord-023095-4dannjjm 2924 6 control control NN cord-023095-4dannjjm 2924 7 study study NN cord-023095-4dannjjm 2924 8 would would MD cord-023095-4dannjjm 2924 9 be be VB cord-023095-4dannjjm 2924 10 needed need VBN cord-023095-4dannjjm 2924 11 in in IN cord-023095-4dannjjm 2924 12 the the DT cord-023095-4dannjjm 2924 13 Boxer Boxer NNP cord-023095-4dannjjm 2924 14 dog dog NN cord-023095-4dannjjm 2924 15 to to TO cord-023095-4dannjjm 2924 16 confirm confirm VB cord-023095-4dannjjm 2924 17 the the DT cord-023095-4dannjjm 2924 18 significance significance NN cord-023095-4dannjjm 2924 19 of of IN cord-023095-4dannjjm 2924 20 the the DT cord-023095-4dannjjm 2924 21 TLR5 TLR5 NNP cord-023095-4dannjjm 2924 22 T443C T443C VBN cord-023095-4dannjjm 2924 23 SNP SNP NNP cord-023095-4dannjjm 2924 24 and and CC cord-023095-4dannjjm 2924 25 further further JJ cord-023095-4dannjjm 2924 26 functional functional JJ cord-023095-4dannjjm 2924 27 data datum NNS cord-023095-4dannjjm 2924 28 would would MD cord-023095-4dannjjm 2924 29 be be VB cord-023095-4dannjjm 2924 30 needed need VBN cord-023095-4dannjjm 2924 31 to to TO cord-023095-4dannjjm 2924 32 elucidate elucidate VB cord-023095-4dannjjm 2924 33 the the DT cord-023095-4dannjjm 2924 34 exact exact JJ cord-023095-4dannjjm 2924 35 role role NN cord-023095-4dannjjm 2924 36 of of IN cord-023095-4dannjjm 2924 37 this this DT cord-023095-4dannjjm 2924 38 polymorphism polymorphism NN cord-023095-4dannjjm 2924 39 in in IN cord-023095-4dannjjm 2924 40 canine canine JJ cord-023095-4dannjjm 2924 41 IBD IBD NNP cord-023095-4dannjjm 2924 42 . . . cord-023095-4dannjjm 2925 1 An an DT cord-023095-4dannjjm 2925 2 automated automate VBN cord-023095-4dannjjm 2925 3 power power NN cord-023095-4dannjjm 2925 4 driver driver NN cord-023095-4dannjjm 2925 5 device device NN cord-023095-4dannjjm 2925 6 ( ( -LRB- cord-023095-4dannjjm 2925 7 OnControl OnControl NNP cord-023095-4dannjjm 2925 8 , , , cord-023095-4dannjjm 2925 9 Vidacare Vidacare NNP cord-023095-4dannjjm 2925 10 ) ) -RRB- cord-023095-4dannjjm 2925 11 has have VBZ cord-023095-4dannjjm 2925 12 recently recently RB cord-023095-4dannjjm 2925 13 become become VBN cord-023095-4dannjjm 2925 14 available available JJ cord-023095-4dannjjm 2925 15 for for IN cord-023095-4dannjjm 2925 16 bone bone NN cord-023095-4dannjjm 2925 17 marrow marrow NN cord-023095-4dannjjm 2925 18 aspiration aspiration NN cord-023095-4dannjjm 2925 19 ( ( -LRB- cord-023095-4dannjjm 2925 20 BMA BMA NNP cord-023095-4dannjjm 2925 21 ) ) -RRB- cord-023095-4dannjjm 2925 22 and and CC cord-023095-4dannjjm 2925 23 bone bone NN cord-023095-4dannjjm 2925 24 marrow marrow NN cord-023095-4dannjjm 2925 25 biopsy biopsy NN cord-023095-4dannjjm 2925 26 ( ( -LRB- cord-023095-4dannjjm 2925 27 BMB BMB NNP cord-023095-4dannjjm 2925 28 ) ) -RRB- cord-023095-4dannjjm 2925 29 in in IN cord-023095-4dannjjm 2925 30 humans human NNS cord-023095-4dannjjm 2925 31 . . . cord-023095-4dannjjm 2926 1 The the DT cord-023095-4dannjjm 2926 2 purpose purpose NN cord-023095-4dannjjm 2926 3 of of IN cord-023095-4dannjjm 2926 4 our -PRON- PRP$ cord-023095-4dannjjm 2926 5 study study NN cord-023095-4dannjjm 2926 6 was be VBD cord-023095-4dannjjm 2926 7 to to TO cord-023095-4dannjjm 2926 8 compare compare VB cord-023095-4dannjjm 2926 9 this this DT cord-023095-4dannjjm 2926 10 automated automated JJ cord-023095-4dannjjm 2926 11 technique technique NN cord-023095-4dannjjm 2926 12 to to IN cord-023095-4dannjjm 2926 13 the the DT cord-023095-4dannjjm 2926 14 traditional traditional JJ cord-023095-4dannjjm 2926 15 manual manual JJ cord-023095-4dannjjm 2926 16 technique technique NN cord-023095-4dannjjm 2926 17 for for IN cord-023095-4dannjjm 2926 18 bone bone NN cord-023095-4dannjjm 2926 19 marrow marrow NN cord-023095-4dannjjm 2926 20 sampling sampling NN cord-023095-4dannjjm 2926 21 in in IN cord-023095-4dannjjm 2926 22 cats cat NNS cord-023095-4dannjjm 2926 23 . . . cord-023095-4dannjjm 2927 1 Twelve twelve CD cord-023095-4dannjjm 2927 2 healthy healthy JJ cord-023095-4dannjjm 2927 3 research research NN cord-023095-4dannjjm 2927 4 cats cat NNS cord-023095-4dannjjm 2927 5 were be VBD cord-023095-4dannjjm 2927 6 anesthetized anesthetize VBN cord-023095-4dannjjm 2927 7 using use VBG cord-023095-4dannjjm 2927 8 a a DT cord-023095-4dannjjm 2927 9 standardized standardized JJ cord-023095-4dannjjm 2927 10 protocol protocol NN cord-023095-4dannjjm 2927 11 on on IN cord-023095-4dannjjm 2927 12 2 2 CD cord-023095-4dannjjm 2927 13 different different JJ cord-023095-4dannjjm 2927 14 occasions occasion NNS cord-023095-4dannjjm 2927 15 , , , cord-023095-4dannjjm 2927 16 2 2 CD cord-023095-4dannjjm 2927 17 days day NNS cord-023095-4dannjjm 2927 18 apart apart RB cord-023095-4dannjjm 2927 19 , , , cord-023095-4dannjjm 2927 20 to to TO cord-023095-4dannjjm 2927 21 have have VB cord-023095-4dannjjm 2927 22 BMAs bma NNS cord-023095-4dannjjm 2927 23 and and CC cord-023095-4dannjjm 2927 24 BMBs BMBs NNP cord-023095-4dannjjm 2927 25 performed perform VBN cord-023095-4dannjjm 2927 26 by by IN cord-023095-4dannjjm 2927 27 the the DT cord-023095-4dannjjm 2927 28 same same JJ cord-023095-4dannjjm 2927 29 operator operator NN cord-023095-4dannjjm 2927 30 . . . cord-023095-4dannjjm 2928 1 On on IN cord-023095-4dannjjm 2928 2 day day NN cord-023095-4dannjjm 2928 3 1 1 CD cord-023095-4dannjjm 2928 4 , , , cord-023095-4dannjjm 2928 5 half half NN cord-023095-4dannjjm 2928 6 of of IN cord-023095-4dannjjm 2928 7 the the DT cord-023095-4dannjjm 2928 8 cats cat NNS cord-023095-4dannjjm 2928 9 were be VBD cord-023095-4dannjjm 2928 10 randomized randomize VBN cord-023095-4dannjjm 2928 11 to to TO cord-023095-4dannjjm 2928 12 have have VB cord-023095-4dannjjm 2928 13 a a DT cord-023095-4dannjjm 2928 14 BMA BMA NNP cord-023095-4dannjjm 2928 15 performed perform VBN cord-023095-4dannjjm 2928 16 at at IN cord-023095-4dannjjm 2928 17 both both CC cord-023095-4dannjjm 2928 18 the the DT cord-023095-4dannjjm 2928 19 proximal proximal JJ cord-023095-4dannjjm 2928 20 humerus humerus NN cord-023095-4dannjjm 2928 21 and and CC cord-023095-4dannjjm 2928 22 the the DT cord-023095-4dannjjm 2928 23 iliac iliac NNP cord-023095-4dannjjm 2928 24 crest crest NN cord-023095-4dannjjm 2928 25 , , , cord-023095-4dannjjm 2928 26 and and CC cord-023095-4dannjjm 2928 27 a a DT cord-023095-4dannjjm 2928 28 BMB BMB NNP cord-023095-4dannjjm 2928 29 performed perform VBN cord-023095-4dannjjm 2928 30 at at IN cord-023095-4dannjjm 2928 31 the the DT cord-023095-4dannjjm 2928 32 iliac iliac NNP cord-023095-4dannjjm 2928 33 wing wing NN cord-023095-4dannjjm 2928 34 , , , cord-023095-4dannjjm 2928 35 using use VBG cord-023095-4dannjjm 2928 36 the the DT cord-023095-4dannjjm 2928 37 OnControl OnControl NNP cord-023095-4dannjjm 2928 38 device device NN cord-023095-4dannjjm 2928 39 ( ( -LRB- cord-023095-4dannjjm 2928 40 15-gauge 15-gauge CD cord-023095-4dannjjm 2928 41 needle needle NN cord-023095-4dannjjm 2928 42 for for IN cord-023095-4dannjjm 2928 43 BMA BMA NNP cord-023095-4dannjjm 2928 44 ; ; : cord-023095-4dannjjm 2928 45 11-gauge 11-gauge CD cord-023095-4dannjjm 2928 46 needle needle NN cord-023095-4dannjjm 2928 47 for for IN cord-023095-4dannjjm 2928 48 BMB BMB NNP cord-023095-4dannjjm 2928 49 ) ) -RRB- cord-023095-4dannjjm 2928 50 . . . cord-023095-4dannjjm 2929 1 The the DT cord-023095-4dannjjm 2929 2 other other JJ cord-023095-4dannjjm 2929 3 half half NN cord-023095-4dannjjm 2929 4 of of IN cord-023095-4dannjjm 2929 5 the the DT cord-023095-4dannjjm 2929 6 cats cat NNS cord-023095-4dannjjm 2929 7 had have VBD cord-023095-4dannjjm 2929 8 the the DT cord-023095-4dannjjm 2929 9 same same JJ cord-023095-4dannjjm 2929 10 procedures procedure NNS cord-023095-4dannjjm 2929 11 performed perform VBN cord-023095-4dannjjm 2929 12 using use VBG cord-023095-4dannjjm 2929 13 a a DT cord-023095-4dannjjm 2929 14 manual manual JJ cord-023095-4dannjjm 2929 15 technique technique NN cord-023095-4dannjjm 2929 16 ( ( -LRB- cord-023095-4dannjjm 2929 17 15-gauge 15-gauge CD cord-023095-4dannjjm 2929 18 Illinois Illinois NNP cord-023095-4dannjjm 2929 19 needle needle NN cord-023095-4dannjjm 2929 20 for for IN cord-023095-4dannjjm 2929 21 BMA BMA NNP cord-023095-4dannjjm 2929 22 ; ; : cord-023095-4dannjjm 2929 23 11-gauge 11-gauge CD cord-023095-4dannjjm 2929 24 Jamshidi Jamshidi NNP cord-023095-4dannjjm 2929 25 needle needle NN cord-023095-4dannjjm 2929 26 for for IN cord-023095-4dannjjm 2929 27 BMB BMB NNP cord-023095-4dannjjm 2929 28 ) ) -RRB- cord-023095-4dannjjm 2929 29 . . . cord-023095-4dannjjm 2930 1 On on IN cord-023095-4dannjjm 2930 2 day day NN cord-023095-4dannjjm 2930 3 3 3 CD cord-023095-4dannjjm 2930 4 , , , cord-023095-4dannjjm 2930 5 each each DT cord-023095-4dannjjm 2930 6 cat cat NN cord-023095-4dannjjm 2930 7 had have VBD cord-023095-4dannjjm 2930 8 BMA BMA NNP cord-023095-4dannjjm 2930 9 performed perform VBN cord-023095-4dannjjm 2930 10 at at IN cord-023095-4dannjjm 2930 11 the the DT cord-023095-4dannjjm 2930 12 opposite opposite JJ cord-023095-4dannjjm 2930 13 humerus humerus NN cord-023095-4dannjjm 2930 14 and and CC cord-023095-4dannjjm 2930 15 iliac iliac NNP cord-023095-4dannjjm 2930 16 crest crest NNP cord-023095-4dannjjm 2930 17 , , , cord-023095-4dannjjm 2930 18 and and CC cord-023095-4dannjjm 2930 19 a a DT cord-023095-4dannjjm 2930 20 BMB BMB NNP cord-023095-4dannjjm 2930 21 performed perform VBN cord-023095-4dannjjm 2930 22 at at IN cord-023095-4dannjjm 2930 23 the the DT cord-023095-4dannjjm 2930 24 proximal proximal JJ cord-023095-4dannjjm 2930 25 humerus humerus NN cord-023095-4dannjjm 2930 26 using use VBG cord-023095-4dannjjm 2930 27 the the DT cord-023095-4dannjjm 2930 28 opposite opposite JJ cord-023095-4dannjjm 2930 29 technique technique NN cord-023095-4dannjjm 2930 30 from from IN cord-023095-4dannjjm 2930 31 day day NN cord-023095-4dannjjm 2930 32 1 1 CD cord-023095-4dannjjm 2930 33 . . . cord-023095-4dannjjm 2931 1 For for IN cord-023095-4dannjjm 2931 2 each each DT cord-023095-4dannjjm 2931 3 procedure procedure NN cord-023095-4dannjjm 2931 4 , , , cord-023095-4dannjjm 2931 5 the the DT cord-023095-4dannjjm 2931 6 operator operator NN cord-023095-4dannjjm 2931 7 was be VBD cord-023095-4dannjjm 2931 8 given give VBN cord-023095-4dannjjm 2931 9 a a DT cord-023095-4dannjjm 2931 10 maximum maximum NN cord-023095-4dannjjm 2931 11 of of IN cord-023095-4dannjjm 2931 12 3 3 CD cord-023095-4dannjjm 2931 13 attempts attempt NNS cord-023095-4dannjjm 2931 14 to to TO cord-023095-4dannjjm 2931 15 successfully successfully RB cord-023095-4dannjjm 2931 16 collect collect VB cord-023095-4dannjjm 2931 17 a a DT cord-023095-4dannjjm 2931 18 sample sample NN cord-023095-4dannjjm 2931 19 . . . cord-023095-4dannjjm 2932 1 The the DT cord-023095-4dannjjm 2932 2 rate rate NN cord-023095-4dannjjm 2932 3 of of IN cord-023095-4dannjjm 2932 4 success success NN cord-023095-4dannjjm 2932 5 , , , cord-023095-4dannjjm 2932 6 as as RB cord-023095-4dannjjm 2932 7 well well RB cord-023095-4dannjjm 2932 8 as as IN cord-023095-4dannjjm 2932 9 the the DT cord-023095-4dannjjm 2932 10 number number NN cord-023095-4dannjjm 2932 11 of of IN cord-023095-4dannjjm 2932 12 attempts attempt NNS cord-023095-4dannjjm 2932 13 were be VBD cord-023095-4dannjjm 2932 14 recorded record VBN cord-023095-4dannjjm 2932 15 . . . cord-023095-4dannjjm 2933 1 The the DT cord-023095-4dannjjm 2933 2 ' ' `` cord-023095-4dannjjm 2933 3 ' ' `` cord-023095-4dannjjm 2933 4 ease ease NN cord-023095-4dannjjm 2933 5 of of IN cord-023095-4dannjjm 2933 6 use use NN cord-023095-4dannjjm 2933 7 ' ' '' cord-023095-4dannjjm 2933 8 ' ' '' cord-023095-4dannjjm 2933 9 of of IN cord-023095-4dannjjm 2933 10 the the DT cord-023095-4dannjjm 2933 11 device device NN cord-023095-4dannjjm 2933 12 was be VBD cord-023095-4dannjjm 2933 13 rated rate VBN cord-023095-4dannjjm 2933 14 by by IN cord-023095-4dannjjm 2933 15 the the DT cord-023095-4dannjjm 2933 16 operator operator NN cord-023095-4dannjjm 2933 17 on on IN cord-023095-4dannjjm 2933 18 a a DT cord-023095-4dannjjm 2933 19 5-point 5-point CD cord-023095-4dannjjm 2933 20 scale scale NN cord-023095-4dannjjm 2933 21 after after IN cord-023095-4dannjjm 2933 22 each each DT cord-023095-4dannjjm 2933 23 procedure procedure NN cord-023095-4dannjjm 2933 24 . . . cord-023095-4dannjjm 2934 1 Using use VBG cord-023095-4dannjjm 2934 2 previously previously RB cord-023095-4dannjjm 2934 3 determined determine VBN cord-023095-4dannjjm 2934 4 criteria criterion NNS cord-023095-4dannjjm 2934 5 , , , cord-023095-4dannjjm 2934 6 the the DT cord-023095-4dannjjm 2934 7 macroscopic macroscopic JJ cord-023095-4dannjjm 2934 8 and and CC cord-023095-4dannjjm 2934 9 microscopic microscopic JJ cord-023095-4dannjjm 2934 10 qualities quality NNS cord-023095-4dannjjm 2934 11 of of IN cord-023095-4dannjjm 2934 12 the the DT cord-023095-4dannjjm 2934 13 BMA BMA NNP cord-023095-4dannjjm 2934 14 and and CC cord-023095-4dannjjm 2934 15 BMB BMB NNP cord-023095-4dannjjm 2934 16 samples sample NNS cord-023095-4dannjjm 2934 17 were be VBD cord-023095-4dannjjm 2934 18 assessed assess VBN cord-023095-4dannjjm 2934 19 by by IN cord-023095-4dannjjm 2934 20 a a DT cord-023095-4dannjjm 2934 21 board board NN cord-023095-4dannjjm 2934 22 - - HYPH cord-023095-4dannjjm 2934 23 certified certify VBN cord-023095-4dannjjm 2934 24 pathologist pathologist NN cord-023095-4dannjjm 2934 25 , , , cord-023095-4dannjjm 2934 26 blinded blind VBN cord-023095-4dannjjm 2934 27 to to IN cord-023095-4dannjjm 2934 28 the the DT cord-023095-4dannjjm 2934 29 technique technique NN cord-023095-4dannjjm 2934 30 used use VBN cord-023095-4dannjjm 2934 31 . . . cord-023095-4dannjjm 2935 1 The the DT cord-023095-4dannjjm 2935 2 level level NN cord-023095-4dannjjm 2935 3 of of IN cord-023095-4dannjjm 2935 4 pain pain NN cord-023095-4dannjjm 2935 5 experienced experience VBN cord-023095-4dannjjm 2935 6 by by IN cord-023095-4dannjjm 2935 7 each each DT cord-023095-4dannjjm 2935 8 cat cat NN cord-023095-4dannjjm 2935 9 was be VBD cord-023095-4dannjjm 2935 10 evaluated evaluate VBN cord-023095-4dannjjm 2935 11 6 6 CD cord-023095-4dannjjm 2935 12 , , , cord-023095-4dannjjm 2935 13 12 12 CD cord-023095-4dannjjm 2935 14 , , , cord-023095-4dannjjm 2935 15 18 18 CD cord-023095-4dannjjm 2935 16 , , , cord-023095-4dannjjm 2935 17 24 24 CD cord-023095-4dannjjm 2935 18 , , , cord-023095-4dannjjm 2935 19 36 36 CD cord-023095-4dannjjm 2935 20 and and CC cord-023095-4dannjjm 2935 21 48 48 CD cord-023095-4dannjjm 2935 22 hours hour NNS cord-023095-4dannjjm 2935 23 following follow VBG cord-023095-4dannjjm 2935 24 each each DT cord-023095-4dannjjm 2935 25 set set NN cord-023095-4dannjjm 2935 26 of of IN cord-023095-4dannjjm 2935 27 procedures procedure NNS cord-023095-4dannjjm 2935 28 , , , cord-023095-4dannjjm 2935 29 using use VBG cord-023095-4dannjjm 2935 30 a a DT cord-023095-4dannjjm 2935 31 previously previously RB cord-023095-4dannjjm 2935 32 validated validate VBN cord-023095-4dannjjm 2935 33 pain pain NN cord-023095-4dannjjm 2935 34 scoring scoring NN cord-023095-4dannjjm 2935 35 system system NN cord-023095-4dannjjm 2935 36 . . . cord-023095-4dannjjm 2936 1 Two two CD cord-023095-4dannjjm 2936 2 sample sample NN cord-023095-4dannjjm 2936 3 t t NN cord-023095-4dannjjm 2936 4 - - HYPH cord-023095-4dannjjm 2936 5 tests test NNS cord-023095-4dannjjm 2936 6 were be VBD cord-023095-4dannjjm 2936 7 used use VBN cord-023095-4dannjjm 2936 8 to to TO cord-023095-4dannjjm 2936 9 compare compare VB cord-023095-4dannjjm 2936 10 the the DT cord-023095-4dannjjm 2936 11 automated automated JJ cord-023095-4dannjjm 2936 12 technique technique NN cord-023095-4dannjjm 2936 13 to to IN cord-023095-4dannjjm 2936 14 the the DT cord-023095-4dannjjm 2936 15 manual manual JJ cord-023095-4dannjjm 2936 16 technique technique NN cord-023095-4dannjjm 2936 17 and and CC cord-023095-4dannjjm 2936 18 to to TO cord-023095-4dannjjm 2936 19 compare compare VB cord-023095-4dannjjm 2936 20 the the DT cord-023095-4dannjjm 2936 21 humerus humerus NN cord-023095-4dannjjm 2936 22 to to IN cord-023095-4dannjjm 2936 23 the the DT cord-023095-4dannjjm 2936 24 iliac iliac NNP cord-023095-4dannjjm 2936 25 crest crest NNP cord-023095-4dannjjm 2936 26 site site NN cord-023095-4dannjjm 2936 27 for for IN cord-023095-4dannjjm 2936 28 BMAs bma NNS cord-023095-4dannjjm 2936 29 and and CC cord-023095-4dannjjm 2936 30 the the DT cord-023095-4dannjjm 2936 31 humerus humerus NN cord-023095-4dannjjm 2936 32 to to IN cord-023095-4dannjjm 2936 33 the the DT cord-023095-4dannjjm 2936 34 iliac iliac JJ cord-023095-4dannjjm 2936 35 wing wing NN cord-023095-4dannjjm 2936 36 site site NN cord-023095-4dannjjm 2936 37 for for IN cord-023095-4dannjjm 2936 38 BMBs BMBs NNP cord-023095-4dannjjm 2936 39 . . . cord-023095-4dannjjm 2937 1 For for IN cord-023095-4dannjjm 2937 2 all all DT cord-023095-4dannjjm 2937 3 procedures procedure NNS cord-023095-4dannjjm 2937 4 , , , cord-023095-4dannjjm 2937 5 at at IN cord-023095-4dannjjm 2937 6 all all DT cord-023095-4dannjjm 2937 7 sites site NNS cord-023095-4dannjjm 2937 8 , , , cord-023095-4dannjjm 2937 9 the the DT cord-023095-4dannjjm 2937 10 ' ' '' cord-023095-4dannjjm 2937 11 ' ' '' cord-023095-4dannjjm 2937 12 ease ease NN cord-023095-4dannjjm 2937 13 of of IN cord-023095-4dannjjm 2937 14 use use NN cord-023095-4dannjjm 2937 15 ' ' '' cord-023095-4dannjjm 2937 16 ' ' '' cord-023095-4dannjjm 2937 17 was be VBD cord-023095-4dannjjm 2937 18 better well JJR cord-023095-4dannjjm 2937 19 for for IN cord-023095-4dannjjm 2937 20 the the DT cord-023095-4dannjjm 2937 21 automated automate VBN cord-023095-4dannjjm 2937 22 technique technique NN cord-023095-4dannjjm 2937 23 than than IN cord-023095-4dannjjm 2937 24 for for IN cord-023095-4dannjjm 2937 25 the the DT cord-023095-4dannjjm 2937 26 manual manual JJ cord-023095-4dannjjm 2937 27 technique technique NN cord-023095-4dannjjm 2937 28 ( ( -LRB- cord-023095-4dannjjm 2937 29 P p NN cord-023095-4dannjjm 2937 30 o o NN cord-023095-4dannjjm 2937 31 0.05 0.05 CD cord-023095-4dannjjm 2937 32 ) ) -RRB- cord-023095-4dannjjm 2937 33 . . . cord-023095-4dannjjm 2938 1 The the DT cord-023095-4dannjjm 2938 2 duration duration NN cord-023095-4dannjjm 2938 3 of of IN cord-023095-4dannjjm 2938 4 the the DT cord-023095-4dannjjm 2938 5 procedure procedure NN cord-023095-4dannjjm 2938 6 and and CC cord-023095-4dannjjm 2938 7 the the DT cord-023095-4dannjjm 2938 8 number number NN cord-023095-4dannjjm 2938 9 of of IN cord-023095-4dannjjm 2938 10 attempts attempt NNS cord-023095-4dannjjm 2938 11 to to TO cord-023095-4dannjjm 2938 12 collect collect VB cord-023095-4dannjjm 2938 13 a a DT cord-023095-4dannjjm 2938 14 sample sample NN cord-023095-4dannjjm 2938 15 were be VBD cord-023095-4dannjjm 2938 16 significantly significantly RB cord-023095-4dannjjm 2938 17 lower low JJR cord-023095-4dannjjm 2938 18 with with IN cord-023095-4dannjjm 2938 19 the the DT cord-023095-4dannjjm 2938 20 automated automate VBN cord-023095-4dannjjm 2938 21 technique technique NN cord-023095-4dannjjm 2938 22 for for IN cord-023095-4dannjjm 2938 23 BMA BMA NNP cord-023095-4dannjjm 2938 24 at at IN cord-023095-4dannjjm 2938 25 the the DT cord-023095-4dannjjm 2938 26 proximal proximal JJ cord-023095-4dannjjm 2938 27 humerus humerus NN cord-023095-4dannjjm 2938 28 ( ( -LRB- cord-023095-4dannjjm 2938 29 P p NN cord-023095-4dannjjm 2938 30 o o NN cord-023095-4dannjjm 2938 31 0.05 0.05 CD cord-023095-4dannjjm 2938 32 ) ) -RRB- cord-023095-4dannjjm 2938 33 . . . cord-023095-4dannjjm 2939 1 There there EX cord-023095-4dannjjm 2939 2 was be VBD cord-023095-4dannjjm 2939 3 no no DT cord-023095-4dannjjm 2939 4 significant significant JJ cord-023095-4dannjjm 2939 5 difference difference NN cord-023095-4dannjjm 2939 6 in in IN cord-023095-4dannjjm 2939 7 the the DT cord-023095-4dannjjm 2939 8 level level NN cord-023095-4dannjjm 2939 9 of of IN cord-023095-4dannjjm 2939 10 pain pain NN cord-023095-4dannjjm 2939 11 at at IN cord-023095-4dannjjm 2939 12 any any DT cord-023095-4dannjjm 2939 13 time time NN cord-023095-4dannjjm 2939 14 point point NN cord-023095-4dannjjm 2939 15 following follow VBG cord-023095-4dannjjm 2939 16 each each DT cord-023095-4dannjjm 2939 17 set set NN cord-023095-4dannjjm 2939 18 of of IN cord-023095-4dannjjm 2939 19 procedures procedure NNS cord-023095-4dannjjm 2939 20 with with IN cord-023095-4dannjjm 2939 21 either either DT cord-023095-4dannjjm 2939 22 technique technique NN cord-023095-4dannjjm 2939 23 . . . cord-023095-4dannjjm 2940 1 Performing perform VBG cord-023095-4dannjjm 2940 2 BMA BMA NNP cord-023095-4dannjjm 2940 3 at at IN cord-023095-4dannjjm 2940 4 the the DT cord-023095-4dannjjm 2940 5 proximal proximal JJ cord-023095-4dannjjm 2940 6 humerus humerus NN cord-023095-4dannjjm 2940 7 was be VBD cord-023095-4dannjjm 2940 8 associated associate VBN cord-023095-4dannjjm 2940 9 with with IN cord-023095-4dannjjm 2940 10 a a DT cord-023095-4dannjjm 2940 11 higher high JJR cord-023095-4dannjjm 2940 12 rate rate NN cord-023095-4dannjjm 2940 13 of of IN cord-023095-4dannjjm 2940 14 success success NN cord-023095-4dannjjm 2940 15 ( ( -LRB- cord-023095-4dannjjm 2940 16 P p NN cord-023095-4dannjjm 2940 17 o o NN cord-023095-4dannjjm 2940 18 0.05 0.05 CD cord-023095-4dannjjm 2940 19 ) ) -RRB- cord-023095-4dannjjm 2940 20 , , , cord-023095-4dannjjm 2940 21 a a DT cord-023095-4dannjjm 2940 22 lower low JJR cord-023095-4dannjjm 2940 23 number number NN cord-023095-4dannjjm 2940 24 of of IN cord-023095-4dannjjm 2940 25 attempts attempt NNS cord-023095-4dannjjm 2940 26 ( ( -LRB- cord-023095-4dannjjm 2940 27 P p NN cord-023095-4dannjjm 2940 28 o o NN cord-023095-4dannjjm 2940 29 0.05 0.05 CD cord-023095-4dannjjm 2940 30 ) ) -RRB- cord-023095-4dannjjm 2940 31 , , , cord-023095-4dannjjm 2940 32 a a DT cord-023095-4dannjjm 2940 33 shorter short JJR cord-023095-4dannjjm 2940 34 duration duration NN cord-023095-4dannjjm 2940 35 of of IN cord-023095-4dannjjm 2940 36 the the DT cord-023095-4dannjjm 2940 37 procedure procedure NN cord-023095-4dannjjm 2940 38 ( ( -LRB- cord-023095-4dannjjm 2940 39 P p NN cord-023095-4dannjjm 2940 40 o o NN cord-023095-4dannjjm 2940 41 0.05 0.05 CD cord-023095-4dannjjm 2940 42 ) ) -RRB- cord-023095-4dannjjm 2940 43 , , , cord-023095-4dannjjm 2940 44 a a DT cord-023095-4dannjjm 2940 45 higher higher RBR cord-023095-4dannjjm 2940 46 - - HYPH cord-023095-4dannjjm 2940 47 rated rate VBN cord-023095-4dannjjm 2940 48 ' ' '' cord-023095-4dannjjm 2940 49 ' ' '' cord-023095-4dannjjm 2940 50 ease ease NN cord-023095-4dannjjm 2940 51 of of IN cord-023095-4dannjjm 2940 52 use use NN cord-023095-4dannjjm 2940 53 ' ' '' cord-023095-4dannjjm 2940 54 ' ' '' cord-023095-4dannjjm 2940 55 of of IN cord-023095-4dannjjm 2940 56 the the DT cord-023095-4dannjjm 2940 57 technique technique NN cord-023095-4dannjjm 2940 58 ( ( -LRB- cord-023095-4dannjjm 2940 59 P p NN cord-023095-4dannjjm 2940 60 o o NN cord-023095-4dannjjm 2940 61 0.05 0.05 CD cord-023095-4dannjjm 2940 62 ) ) -RRB- cord-023095-4dannjjm 2940 63 , , , cord-023095-4dannjjm 2940 64 and and CC cord-023095-4dannjjm 2940 65 a a DT cord-023095-4dannjjm 2940 66 better well JJR cord-023095-4dannjjm 2940 67 quality quality NN cord-023095-4dannjjm 2940 68 sample sample NN cord-023095-4dannjjm 2940 69 ( ( -LRB- cord-023095-4dannjjm 2940 70 P p NN cord-023095-4dannjjm 2940 71 o o NN cord-023095-4dannjjm 2940 72 0.05 0.05 CD cord-023095-4dannjjm 2940 73 ) ) -RRB- cord-023095-4dannjjm 2940 74 when when WRB cord-023095-4dannjjm 2940 75 compared compare VBN cord-023095-4dannjjm 2940 76 to to IN cord-023095-4dannjjm 2940 77 sampling sampling NN cord-023095-4dannjjm 2940 78 from from IN cord-023095-4dannjjm 2940 79 the the DT cord-023095-4dannjjm 2940 80 iliac iliac NNP cord-023095-4dannjjm 2940 81 crest crest NN cord-023095-4dannjjm 2940 82 , , , cord-023095-4dannjjm 2941 1 In in IN cord-023095-4dannjjm 2941 2 conclusion conclusion NN cord-023095-4dannjjm 2941 3 , , , cord-023095-4dannjjm 2941 4 we -PRON- PRP cord-023095-4dannjjm 2941 5 found find VBD cord-023095-4dannjjm 2941 6 the the DT cord-023095-4dannjjm 2941 7 automated automate VBN cord-023095-4dannjjm 2941 8 bone bone NN cord-023095-4dannjjm 2941 9 marrow marrow NN cord-023095-4dannjjm 2941 10 sampling sampling NN cord-023095-4dannjjm 2941 11 technique technique NN cord-023095-4dannjjm 2941 12 suitable suitable JJ cord-023095-4dannjjm 2941 13 for for IN cord-023095-4dannjjm 2941 14 use use NN cord-023095-4dannjjm 2941 15 in in IN cord-023095-4dannjjm 2941 16 adult adult NN cord-023095-4dannjjm 2941 17 cats cat NNS cord-023095-4dannjjm 2941 18 . . . cord-023095-4dannjjm 2942 1 This this DT cord-023095-4dannjjm 2942 2 technique technique NN cord-023095-4dannjjm 2942 3 was be VBD cord-023095-4dannjjm 2942 4 easier easy JJR cord-023095-4dannjjm 2942 5 to to TO cord-023095-4dannjjm 2942 6 use use VB cord-023095-4dannjjm 2942 7 than than IN cord-023095-4dannjjm 2942 8 the the DT cord-023095-4dannjjm 2942 9 manual manual JJ cord-023095-4dannjjm 2942 10 technique technique NN cord-023095-4dannjjm 2942 11 for for IN cord-023095-4dannjjm 2942 12 both both CC cord-023095-4dannjjm 2942 13 BMA BMA NNP cord-023095-4dannjjm 2942 14 and and CC cord-023095-4dannjjm 2942 15 BMB BMB NNP cord-023095-4dannjjm 2942 16 , , , cord-023095-4dannjjm 2942 17 and and CC cord-023095-4dannjjm 2942 18 reduced reduce VBD cord-023095-4dannjjm 2942 19 the the DT cord-023095-4dannjjm 2942 20 duration duration NN cord-023095-4dannjjm 2942 21 of of IN cord-023095-4dannjjm 2942 22 the the DT cord-023095-4dannjjm 2942 23 procedure procedure NN cord-023095-4dannjjm 2942 24 and and CC cord-023095-4dannjjm 2942 25 the the DT cord-023095-4dannjjm 2942 26 number number NN cord-023095-4dannjjm 2942 27 of of IN cord-023095-4dannjjm 2942 28 attempts attempt NNS cord-023095-4dannjjm 2942 29 for for IN cord-023095-4dannjjm 2942 30 successful successful JJ cord-023095-4dannjjm 2942 31 BMA BMA NNP cord-023095-4dannjjm 2942 32 at at IN cord-023095-4dannjjm 2942 33 the the DT cord-023095-4dannjjm 2942 34 proximal proximal JJ cord-023095-4dannjjm 2942 35 humerus humerus NN cord-023095-4dannjjm 2942 36 . . . cord-023095-4dannjjm 2943 1 Performing perform VBG cord-023095-4dannjjm 2943 2 BMA BMA NNP cord-023095-4dannjjm 2943 3 at at IN cord-023095-4dannjjm 2943 4 the the DT cord-023095-4dannjjm 2943 5 proximal proximal JJ cord-023095-4dannjjm 2943 6 humerus humerus NN cord-023095-4dannjjm 2943 7 was be VBD cord-023095-4dannjjm 2943 8 faster fast JJR cord-023095-4dannjjm 2943 9 , , , cord-023095-4dannjjm 2943 10 easier easy JJR cord-023095-4dannjjm 2943 11 and and CC cord-023095-4dannjjm 2943 12 allowed allow VBN cord-023095-4dannjjm 2943 13 collection collection NN cord-023095-4dannjjm 2943 14 of of IN cord-023095-4dannjjm 2943 15 better well JJR cord-023095-4dannjjm 2943 16 quality quality NN cord-023095-4dannjjm 2943 17 samples sample NNS cord-023095-4dannjjm 2943 18 than than IN cord-023095-4dannjjm 2943 19 at at IN cord-023095-4dannjjm 2943 20 the the DT cord-023095-4dannjjm 2943 21 iliac iliac NNP cord-023095-4dannjjm 2943 22 crest crest NN cord-023095-4dannjjm 2943 23 , , , cord-023095-4dannjjm 2943 24 independently independently RB cord-023095-4dannjjm 2943 25 of of IN cord-023095-4dannjjm 2943 26 the the DT cord-023095-4dannjjm 2943 27 technique technique NN cord-023095-4dannjjm 2943 28 used use VBN cord-023095-4dannjjm 2943 29 . . . cord-023095-4dannjjm 2944 1 The the DT cord-023095-4dannjjm 2944 2 fractious fractious JJ cord-023095-4dannjjm 2944 3 nature nature NN cord-023095-4dannjjm 2944 4 of of IN cord-023095-4dannjjm 2944 5 some some DT cord-023095-4dannjjm 2944 6 feline feline JJ cord-023095-4dannjjm 2944 7 patients patient NNS cord-023095-4dannjjm 2944 8 sometimes sometimes RB cord-023095-4dannjjm 2944 9 makes make VBZ cord-023095-4dannjjm 2944 10 sedation sedation NN cord-023095-4dannjjm 2944 11 or or CC cord-023095-4dannjjm 2944 12 general general JJ cord-023095-4dannjjm 2944 13 anesthesia anesthesia NN cord-023095-4dannjjm 2944 14 necessary necessary JJ cord-023095-4dannjjm 2944 15 for for IN cord-023095-4dannjjm 2944 16 routine routine JJ cord-023095-4dannjjm 2944 17 procedures procedure NNS cord-023095-4dannjjm 2944 18 such such JJ cord-023095-4dannjjm 2944 19 as as IN cord-023095-4dannjjm 2944 20 blood blood NN cord-023095-4dannjjm 2944 21 collection collection NN cord-023095-4dannjjm 2944 22 for for IN cord-023095-4dannjjm 2944 23 hematologic hematologic JJ cord-023095-4dannjjm 2944 24 analyses analysis NNS cord-023095-4dannjjm 2944 25 . . . cord-023095-4dannjjm 2945 1 It -PRON- PRP cord-023095-4dannjjm 2945 2 has have VBZ cord-023095-4dannjjm 2945 3 been be VBN cord-023095-4dannjjm 2945 4 anecdotally anecdotally RB cord-023095-4dannjjm 2945 5 reported report VBN cord-023095-4dannjjm 2945 6 that that IN cord-023095-4dannjjm 2945 7 sedation sedation NN cord-023095-4dannjjm 2945 8 or or CC cord-023095-4dannjjm 2945 9 general general JJ cord-023095-4dannjjm 2945 10 anesthesia anesthesia NN cord-023095-4dannjjm 2945 11 could could MD cord-023095-4dannjjm 2945 12 induce induce VB cord-023095-4dannjjm 2945 13 variations variation NNS cord-023095-4dannjjm 2945 14 in in IN cord-023095-4dannjjm 2945 15 hematologic hematologic JJ cord-023095-4dannjjm 2945 16 parameters parameter NNS cord-023095-4dannjjm 2945 17 in in IN cord-023095-4dannjjm 2945 18 cats cat NNS cord-023095-4dannjjm 2945 19 , , , cord-023095-4dannjjm 2945 20 making make VBG cord-023095-4dannjjm 2945 21 it -PRON- PRP cord-023095-4dannjjm 2945 22 important important JJ cord-023095-4dannjjm 2945 23 for for IN cord-023095-4dannjjm 2945 24 the the DT cord-023095-4dannjjm 2945 25 clinician clinician NN cord-023095-4dannjjm 2945 26 to to TO cord-023095-4dannjjm 2945 27 be be VB cord-023095-4dannjjm 2945 28 able able JJ cord-023095-4dannjjm 2945 29 to to TO cord-023095-4dannjjm 2945 30 anticipate anticipate VB cord-023095-4dannjjm 2945 31 potential potential JJ cord-023095-4dannjjm 2945 32 changes change NNS cord-023095-4dannjjm 2945 33 on on IN cord-023095-4dannjjm 2945 34 hematologic hematologic JJ cord-023095-4dannjjm 2945 35 parameters parameter NNS cord-023095-4dannjjm 2945 36 that that WDT cord-023095-4dannjjm 2945 37 could could MD cord-023095-4dannjjm 2945 38 result result VB cord-023095-4dannjjm 2945 39 from from IN cord-023095-4dannjjm 2945 40 chemical chemical JJ cord-023095-4dannjjm 2945 41 restraint restraint NN cord-023095-4dannjjm 2945 42 . . . cord-023095-4dannjjm 2946 1 This this DT cord-023095-4dannjjm 2946 2 study study NN cord-023095-4dannjjm 2946 3 evaluated evaluate VBD cord-023095-4dannjjm 2946 4 the the DT cord-023095-4dannjjm 2946 5 effects effect NNS cord-023095-4dannjjm 2946 6 of of IN cord-023095-4dannjjm 2946 7 a a DT cord-023095-4dannjjm 2946 8 standardizecd standardizecd JJ cord-023095-4dannjjm 2946 9 anesthetic anesthetic NN cord-023095-4dannjjm 2946 10 protocol protocol NN cord-023095-4dannjjm 2946 11 using use VBG cord-023095-4dannjjm 2946 12 ketamine ketamine NNP cord-023095-4dannjjm 2946 13 ( ( -LRB- cord-023095-4dannjjm 2946 14 10 10 CD cord-023095-4dannjjm 2946 15 mg mg NNP cord-023095-4dannjjm 2946 16 / / SYM cord-023095-4dannjjm 2946 17 kg kg NNP cord-023095-4dannjjm 2946 18 , , , cord-023095-4dannjjm 2946 19 IV IV NNP cord-023095-4dannjjm 2946 20 ) ) -RRB- cord-023095-4dannjjm 2946 21 , , , cord-023095-4dannjjm 2946 22 midazolam midazolam NNP cord-023095-4dannjjm 2946 23 ( ( -LRB- cord-023095-4dannjjm 2946 24 0.5 0.5 CD cord-023095-4dannjjm 2946 25 mg mg NNP cord-023095-4dannjjm 2946 26 / / SYM cord-023095-4dannjjm 2946 27 kg kg NNP cord-023095-4dannjjm 2946 28 , , , cord-023095-4dannjjm 2946 29 IV IV NNP cord-023095-4dannjjm 2946 30 ) ) -RRB- cord-023095-4dannjjm 2946 31 and and CC cord-023095-4dannjjm 2946 32 buprenorphine buprenorphine NN cord-023095-4dannjjm 2946 33 ( ( -LRB- cord-023095-4dannjjm 2946 34 10 10 CD cord-023095-4dannjjm 2946 35 mg mg NNP cord-023095-4dannjjm 2946 36 / / SYM cord-023095-4dannjjm 2946 37 kg kg NNP cord-023095-4dannjjm 2946 38 , , , cord-023095-4dannjjm 2946 39 IM IM NNP cord-023095-4dannjjm 2946 40 ) ) -RRB- cord-023095-4dannjjm 2946 41 on on IN cord-023095-4dannjjm 2946 42 the the DT cord-023095-4dannjjm 2946 43 hematologic hematologic JJ cord-023095-4dannjjm 2946 44 parameters parameter NNS cord-023095-4dannjjm 2946 45 of of IN cord-023095-4dannjjm 2946 46 12 12 CD cord-023095-4dannjjm 2946 47 healthy healthy JJ cord-023095-4dannjjm 2946 48 adult adult NN cord-023095-4dannjjm 2946 49 research research NN cord-023095-4dannjjm 2946 50 cats cat NNS cord-023095-4dannjjm 2946 51 . . . cord-023095-4dannjjm 2947 1 Each each DT cord-023095-4dannjjm 2947 2 cat cat NN cord-023095-4dannjjm 2947 3 had have VBD cord-023095-4dannjjm 2947 4 blood blood NN cord-023095-4dannjjm 2947 5 samples sample NNS cord-023095-4dannjjm 2947 6 collected collect VBN cord-023095-4dannjjm 2947 7 before before RB cord-023095-4dannjjm 2947 8 and and CC cord-023095-4dannjjm 2947 9 after after IN cord-023095-4dannjjm 2947 10 induction induction NN cord-023095-4dannjjm 2947 11 of of IN cord-023095-4dannjjm 2947 12 anesthesia anesthesia NN cord-023095-4dannjjm 2947 13 on on IN cord-023095-4dannjjm 2947 14 2 2 CD cord-023095-4dannjjm 2947 15 different different JJ cord-023095-4dannjjm 2947 16 occasions occasion NNS cord-023095-4dannjjm 2947 17 , , , cord-023095-4dannjjm 2947 18 2 2 CD cord-023095-4dannjjm 2947 19 days day NNS cord-023095-4dannjjm 2947 20 apart apart RB cord-023095-4dannjjm 2947 21 . . . cord-023095-4dannjjm 2948 1 In in IN cord-023095-4dannjjm 2948 2 total total JJ cord-023095-4dannjjm 2948 3 , , , cord-023095-4dannjjm 2948 4 24 24 CD cord-023095-4dannjjm 2948 5 pairs pair NNS cord-023095-4dannjjm 2948 6 of of IN cord-023095-4dannjjm 2948 7 complete complete JJ cord-023095-4dannjjm 2948 8 blood blood NN cord-023095-4dannjjm 2948 9 counts count NNS cord-023095-4dannjjm 2948 10 were be VBD cord-023095-4dannjjm 2948 11 obtained obtain VBN cord-023095-4dannjjm 2948 12 . . . cord-023095-4dannjjm 2949 1 Analyses analysis NNS cord-023095-4dannjjm 2949 2 were be VBD cord-023095-4dannjjm 2949 3 performed perform VBN cord-023095-4dannjjm 2949 4 at at IN cord-023095-4dannjjm 2949 5 a a DT cord-023095-4dannjjm 2949 6 certified certify VBN cord-023095-4dannjjm 2949 7 veterinary veterinary JJ cord-023095-4dannjjm 2949 8 laboratory laboratory NN cord-023095-4dannjjm 2949 9 . . . cord-023095-4dannjjm 2950 1 Paired pair VBN cord-023095-4dannjjm 2950 2 sample sample NN cord-023095-4dannjjm 2950 3 t t NN cord-023095-4dannjjm 2950 4 - - HYPH cord-023095-4dannjjm 2950 5 tests test NNS cord-023095-4dannjjm 2950 6 were be VBD cord-023095-4dannjjm 2950 7 used use VBN cord-023095-4dannjjm 2950 8 to to TO cord-023095-4dannjjm 2950 9 determine determine VB cord-023095-4dannjjm 2950 10 whether whether IN cord-023095-4dannjjm 2950 11 there there EX cord-023095-4dannjjm 2950 12 were be VBD cord-023095-4dannjjm 2950 13 any any DT cord-023095-4dannjjm 2950 14 statistical statistical JJ cord-023095-4dannjjm 2950 15 differences difference NNS cord-023095-4dannjjm 2950 16 between between IN cord-023095-4dannjjm 2950 17 hematologic hematologic JJ cord-023095-4dannjjm 2950 18 parameters parameter NNS cord-023095-4dannjjm 2950 19 before before IN cord-023095-4dannjjm 2950 20 and and CC cord-023095-4dannjjm 2950 21 after after IN cord-023095-4dannjjm 2950 22 induction induction NN cord-023095-4dannjjm 2950 23 of of IN cord-023095-4dannjjm 2950 24 general general JJ cord-023095-4dannjjm 2950 25 anesthesia anesthesia NNP cord-023095-4dannjjm 2950 26 , , , cord-023095-4dannjjm 2950 27 for for IN cord-023095-4dannjjm 2950 28 each each DT cord-023095-4dannjjm 2950 29 cat cat NN cord-023095-4dannjjm 2950 30 , , , cord-023095-4dannjjm 2950 31 on on IN cord-023095-4dannjjm 2950 32 2 2 CD cord-023095-4dannjjm 2950 33 different different JJ cord-023095-4dannjjm 2950 34 occasions occasion NNS cord-023095-4dannjjm 2950 35 . . . cord-023095-4dannjjm 2951 1 Compared compare VBN cord-023095-4dannjjm 2951 2 to to IN cord-023095-4dannjjm 2951 3 preanesthetic preanesthetic JJ cord-023095-4dannjjm 2951 4 values value NNS cord-023095-4dannjjm 2951 5 there there EX cord-023095-4dannjjm 2951 6 was be VBD cord-023095-4dannjjm 2951 7 a a DT cord-023095-4dannjjm 2951 8 significant significant JJ cord-023095-4dannjjm 2951 9 decrease decrease NN cord-023095-4dannjjm 2951 10 in in IN cord-023095-4dannjjm 2951 11 red red JJ cord-023095-4dannjjm 2951 12 blood blood NN cord-023095-4dannjjm 2951 13 cell cell NN cord-023095-4dannjjm 2951 14 count count NN cord-023095-4dannjjm 2951 15 , , , cord-023095-4dannjjm 2951 16 hemoglobin hemoglobin NN cord-023095-4dannjjm 2951 17 concentration concentration NN cord-023095-4dannjjm 2951 18 , , , cord-023095-4dannjjm 2951 19 hematocrit hematocrit NN cord-023095-4dannjjm 2951 20 , , , cord-023095-4dannjjm 2951 21 lymphocyte lymphocyte NN cord-023095-4dannjjm 2951 22 count count NN cord-023095-4dannjjm 2951 23 and and CC cord-023095-4dannjjm 2951 24 plasma plasma VBD cord-023095-4dannjjm 2951 25 total total JJ cord-023095-4dannjjm 2951 26 protein protein NN cord-023095-4dannjjm 2951 27 concentration concentration NN cord-023095-4dannjjm 2951 28 after after IN cord-023095-4dannjjm 2951 29 induction induction NN cord-023095-4dannjjm 2951 30 of of IN cord-023095-4dannjjm 2951 31 anesthesia anesthesia NN cord-023095-4dannjjm 2951 32 . . . cord-023095-4dannjjm 2952 1 There there EX cord-023095-4dannjjm 2952 2 was be VBD cord-023095-4dannjjm 2952 3 no no DT cord-023095-4dannjjm 2952 4 significant significant JJ cord-023095-4dannjjm 2952 5 difference difference NN cord-023095-4dannjjm 2952 6 in in IN cord-023095-4dannjjm 2952 7 the the DT cord-023095-4dannjjm 2952 8 segmented segmented JJ cord-023095-4dannjjm 2952 9 or or CC cord-023095-4dannjjm 2952 10 band band NN cord-023095-4dannjjm 2952 11 neutrophil neutrophil NN cord-023095-4dannjjm 2952 12 , , , cord-023095-4dannjjm 2952 13 eosinophil eosinophil NN cord-023095-4dannjjm 2952 14 , , , cord-023095-4dannjjm 2952 15 basophil basophil NNP cord-023095-4dannjjm 2952 16 , , , cord-023095-4dannjjm 2952 17 monocyte monocyte NNP cord-023095-4dannjjm 2952 18 and and CC cord-023095-4dannjjm 2952 19 platelet platelet NN cord-023095-4dannjjm 2952 20 counts count VBZ cord-023095-4dannjjm 2952 21 between between IN cord-023095-4dannjjm 2952 22 the the DT cord-023095-4dannjjm 2952 23 samples sample NNS cord-023095-4dannjjm 2952 24 taken take VBN cord-023095-4dannjjm 2952 25 before before RB cord-023095-4dannjjm 2952 26 and and CC cord-023095-4dannjjm 2952 27 after after IN cord-023095-4dannjjm 2952 28 induction induction NN cord-023095-4dannjjm 2952 29 of of IN cord-023095-4dannjjm 2952 30 anesthesia anesthesia NN cord-023095-4dannjjm 2952 31 . . . cord-023095-4dannjjm 2953 1 On on IN cord-023095-4dannjjm 2953 2 average average JJ cord-023095-4dannjjm 2953 3 , , , cord-023095-4dannjjm 2953 4 there there EX cord-023095-4dannjjm 2953 5 was be VBD cord-023095-4dannjjm 2953 6 a a DT cord-023095-4dannjjm 2953 7 23.7 23.7 CD cord-023095-4dannjjm 2953 8 % % NN cord-023095-4dannjjm 2953 9 decrease decrease NN cord-023095-4dannjjm 2953 10 in in IN cord-023095-4dannjjm 2953 11 the the DT cord-023095-4dannjjm 2953 12 red red JJ cord-023095-4dannjjm 2953 13 blood blood NN cord-023095-4dannjjm 2953 14 cell cell NN cord-023095-4dannjjm 2953 15 count count NN cord-023095-4dannjjm 2953 16 ( ( -LRB- cord-023095-4dannjjm 2953 17 9.06 9.06 CD cord-023095-4dannjjm 2953 18 Â â CD cord-023095-4dannjjm 2954 1 10 10 CD cord-023095-4dannjjm 2954 2 12 12 CD cord-023095-4dannjjm 2954 3 /L /l CD cord-023095-4dannjjm 2954 4 to to IN cord-023095-4dannjjm 2954 5 6.91 6.91 CD cord-023095-4dannjjm 2954 6 Â â CD cord-023095-4dannjjm 2954 7 10 10 CD cord-023095-4dannjjm 2954 8 12 12 CD cord-023095-4dannjjm 2954 9 /L /L . cord-023095-4dannjjm 2954 10 ) ) -RRB- cord-023095-4dannjjm 2955 1 ( ( -LRB- cord-023095-4dannjjm 2955 2 P p NN cord-023095-4dannjjm 2955 3 o o CD cord-023095-4dannjjm 2955 4 0.0001 0.0001 CD cord-023095-4dannjjm 2955 5 ) ) -RRB- cord-023095-4dannjjm 2955 6 , , , cord-023095-4dannjjm 2955 7 a a DT cord-023095-4dannjjm 2955 8 23 23 CD cord-023095-4dannjjm 2955 9 % % NN cord-023095-4dannjjm 2955 10 decrease decrease NN cord-023095-4dannjjm 2955 11 in in IN cord-023095-4dannjjm 2955 12 hemoglobin hemoglobin NN cord-023095-4dannjjm 2955 13 concentration concentration NN cord-023095-4dannjjm 2955 14 ( ( -LRB- cord-023095-4dannjjm 2955 15 133.88 133.88 CD cord-023095-4dannjjm 2955 16 g g NN cord-023095-4dannjjm 2955 17 / / SYM cord-023095-4dannjjm 2955 18 L l NN cord-023095-4dannjjm 2955 19 to to IN cord-023095-4dannjjm 2955 20 103.08 103.08 CD cord-023095-4dannjjm 2955 21 g/ g/ JJ cord-023095-4dannjjm 2955 22 L l NN cord-023095-4dannjjm 2955 23 ) ) -RRB- cord-023095-4dannjjm 2956 1 ( ( -LRB- cord-023095-4dannjjm 2956 2 P p NN cord-023095-4dannjjm 2956 3 o o CD cord-023095-4dannjjm 2956 4 0.0001 0.0001 CD cord-023095-4dannjjm 2956 5 ) ) -RRB- cord-023095-4dannjjm 2956 6 , , , cord-023095-4dannjjm 2956 7 a a DT cord-023095-4dannjjm 2956 8 24.4 24.4 CD cord-023095-4dannjjm 2956 9 % % NN cord-023095-4dannjjm 2956 10 decrease decrease NN cord-023095-4dannjjm 2956 11 in in IN cord-023095-4dannjjm 2956 12 the the DT cord-023095-4dannjjm 2956 13 hematocrit hematocrit NN cord-023095-4dannjjm 2956 14 ( ( -LRB- cord-023095-4dannjjm 2956 15 0.41 0.41 CD cord-023095-4dannjjm 2956 16 L l NN cord-023095-4dannjjm 2956 17 / / SYM cord-023095-4dannjjm 2956 18 L l NN cord-023095-4dannjjm 2956 19 to to IN cord-023095-4dannjjm 2956 20 0.31 0.31 CD cord-023095-4dannjjm 2956 21 L l NN cord-023095-4dannjjm 2956 22 / / SYM cord-023095-4dannjjm 2956 23 L l NN cord-023095-4dannjjm 2956 24 ) ) -RRB- cord-023095-4dannjjm 2957 1 ( ( -LRB- cord-023095-4dannjjm 2957 2 P p NN cord-023095-4dannjjm 2957 3 o o CD cord-023095-4dannjjm 2957 4 0.0001 0.0001 CD cord-023095-4dannjjm 2957 5 ) ) -RRB- cord-023095-4dannjjm 2957 6 , , , cord-023095-4dannjjm 2957 7 a a DT cord-023095-4dannjjm 2957 8 25.3 25.3 CD cord-023095-4dannjjm 2957 9 % % NN cord-023095-4dannjjm 2957 10 decrease decrease NN cord-023095-4dannjjm 2957 11 in in IN cord-023095-4dannjjm 2957 12 the the DT cord-023095-4dannjjm 2957 13 lymphocyte lymphocyte NN cord-023095-4dannjjm 2957 14 count count NN cord-023095-4dannjjm 2957 15 ( ( -LRB- cord-023095-4dannjjm 2957 16 3.68 3.68 CD cord-023095-4dannjjm 2957 17 Â â CD cord-023095-4dannjjm 2957 18 10 10 CD cord-023095-4dannjjm 2957 19 9 9 CD cord-023095-4dannjjm 2957 20 /L /l CD cord-023095-4dannjjm 2957 21 to to IN cord-023095-4dannjjm 2957 22 2.77 2.77 CD cord-023095-4dannjjm 2957 23 Â â CD cord-023095-4dannjjm 2957 24 10 10 CD cord-023095-4dannjjm 2957 25 9 9 CD cord-023095-4dannjjm 2957 26 /L /L . cord-023095-4dannjjm 2957 27 ) ) -RRB- cord-023095-4dannjjm 2958 1 ( ( -LRB- cord-023095-4dannjjm 2958 2 P p NN cord-023095-4dannjjm 2958 3 5 5 CD cord-023095-4dannjjm 2958 4 0.0023 0.0023 CD cord-023095-4dannjjm 2958 5 ) ) -RRB- cord-023095-4dannjjm 2958 6 , , , cord-023095-4dannjjm 2958 7 and and CC cord-023095-4dannjjm 2958 8 a a DT cord-023095-4dannjjm 2958 9 12.1 12.1 CD cord-023095-4dannjjm 2958 10 % % NN cord-023095-4dannjjm 2958 11 decrease decrease NN cord-023095-4dannjjm 2958 12 in in IN cord-023095-4dannjjm 2958 13 the the DT cord-023095-4dannjjm 2958 14 plasma plasma NN cord-023095-4dannjjm 2958 15 total total JJ cord-023095-4dannjjm 2958 16 protein protein NN cord-023095-4dannjjm 2958 17 concentration concentration NN cord-023095-4dannjjm 2958 18 ( ( -LRB- cord-023095-4dannjjm 2958 19 84.79 84.79 CD cord-023095-4dannjjm 2958 20 g g NN cord-023095-4dannjjm 2958 21 / / SYM cord-023095-4dannjjm 2958 22 L l NN cord-023095-4dannjjm 2958 23 to to IN cord-023095-4dannjjm 2958 24 74.54 74.54 CD cord-023095-4dannjjm 2958 25 g g NN cord-023095-4dannjjm 2958 26 / / SYM cord-023095-4dannjjm 2958 27 L l NN cord-023095-4dannjjm 2958 28 ) ) -RRB- cord-023095-4dannjjm 2959 1 ( ( -LRB- cord-023095-4dannjjm 2959 2 P p NN cord-023095-4dannjjm 2959 3 o o NN cord-023095-4dannjjm 2960 1 0.0001 0.0001 LS cord-023095-4dannjjm 2960 2 ) ) -RRB- cord-023095-4dannjjm 2960 3 when when WRB cord-023095-4dannjjm 2960 4 samples sample NNS cord-023095-4dannjjm 2960 5 taken take VBN cord-023095-4dannjjm 2960 6 before before RB cord-023095-4dannjjm 2960 7 and and CC cord-023095-4dannjjm 2960 8 after after IN cord-023095-4dannjjm 2960 9 induction induction NN cord-023095-4dannjjm 2960 10 of of IN cord-023095-4dannjjm 2960 11 anesthesia anesthesia NN cord-023095-4dannjjm 2960 12 were be VBD cord-023095-4dannjjm 2960 13 compared compare VBN cord-023095-4dannjjm 2960 14 . . . cord-023095-4dannjjm 2961 1 If if IN cord-023095-4dannjjm 2961 2 only only RB cord-023095-4dannjjm 2961 3 the the DT cord-023095-4dannjjm 2961 4 hematocrit hematocrit NN cord-023095-4dannjjm 2961 5 was be VBD cord-023095-4dannjjm 2961 6 considered consider VBN cord-023095-4dannjjm 2961 7 as as IN cord-023095-4dannjjm 2961 8 a a DT cord-023095-4dannjjm 2961 9 marker marker NN cord-023095-4dannjjm 2961 10 of of IN cord-023095-4dannjjm 2961 11 anemia anemia NN cord-023095-4dannjjm 2961 12 , , , cord-023095-4dannjjm 2961 13 29 29 CD cord-023095-4dannjjm 2961 14 % % NN cord-023095-4dannjjm 2961 15 of of IN cord-023095-4dannjjm 2961 16 the the DT cord-023095-4dannjjm 2961 17 samples sample NNS cord-023095-4dannjjm 2961 18 from from IN cord-023095-4dannjjm 2961 19 these these DT cord-023095-4dannjjm 2961 20 12 12 CD cord-023095-4dannjjm 2961 21 healthy healthy JJ cord-023095-4dannjjm 2961 22 cats cat NNS cord-023095-4dannjjm 2961 23 , , , cord-023095-4dannjjm 2961 24 taken take VBN cord-023095-4dannjjm 2961 25 while while IN cord-023095-4dannjjm 2961 26 they -PRON- PRP cord-023095-4dannjjm 2961 27 were be VBD cord-023095-4dannjjm 2961 28 under under IN cord-023095-4dannjjm 2961 29 general general JJ cord-023095-4dannjjm 2961 30 anesthesia anesthesia NN cord-023095-4dannjjm 2961 31 , , , cord-023095-4dannjjm 2961 32 would would MD cord-023095-4dannjjm 2961 33 have have VB cord-023095-4dannjjm 2961 34 been be VBN cord-023095-4dannjjm 2961 35 misinterpreted misinterpret VBN cord-023095-4dannjjm 2961 36 as as IN cord-023095-4dannjjm 2961 37 belonging belong VBG cord-023095-4dannjjm 2961 38 to to IN cord-023095-4dannjjm 2961 39 anemic anemic JJ cord-023095-4dannjjm 2961 40 patients patient NNS cord-023095-4dannjjm 2961 41 ( ( -LRB- cord-023095-4dannjjm 2961 42 hematocrit hematocrit NN cord-023095-4dannjjm 2961 43 o o NN cord-023095-4dannjjm 2961 44 0.285 0.285 CD cord-023095-4dannjjm 2961 45 L L NNP cord-023095-4dannjjm 2961 46 / / SYM cord-023095-4dannjjm 2961 47 L L NNP cord-023095-4dannjjm 2961 48 ) ) -RRB- cord-023095-4dannjjm 2961 49 , , , cord-023095-4dannjjm 2961 50 using use VBG cord-023095-4dannjjm 2961 51 the the DT cord-023095-4dannjjm 2961 52 reference reference NN cord-023095-4dannjjm 2961 53 interval interval NN cord-023095-4dannjjm 2961 54 established establish VBN cord-023095-4dannjjm 2961 55 in in IN cord-023095-4dannjjm 2961 56 our -PRON- PRP$ cord-023095-4dannjjm 2961 57 laboratory laboratory NN cord-023095-4dannjjm 2961 58 . . . cord-023095-4dannjjm 2962 1 None none NN cord-023095-4dannjjm 2962 2 of of IN cord-023095-4dannjjm 2962 3 the the DT cord-023095-4dannjjm 2962 4 cats cat NNS cord-023095-4dannjjm 2962 5 would would MD cord-023095-4dannjjm 2962 6 have have VB cord-023095-4dannjjm 2962 7 been be VBN cord-023095-4dannjjm 2962 8 considered consider VBN cord-023095-4dannjjm 2962 9 anemic anemic JJ cord-023095-4dannjjm 2962 10 before before IN cord-023095-4dannjjm 2962 11 induction induction NN cord-023095-4dannjjm 2962 12 of of IN cord-023095-4dannjjm 2962 13 general general JJ cord-023095-4dannjjm 2962 14 anesthesia anesthesia NNP cord-023095-4dannjjm 2962 15 . . . cord-023095-4dannjjm 2963 1 In in IN cord-023095-4dannjjm 2963 2 practice practice NN cord-023095-4dannjjm 2963 3 , , , cord-023095-4dannjjm 2963 4 the the DT cord-023095-4dannjjm 2963 5 decrease decrease NN cord-023095-4dannjjm 2963 6 in in IN cord-023095-4dannjjm 2963 7 lymphocyte lymphocyte NN cord-023095-4dannjjm 2963 8 count count NN cord-023095-4dannjjm 2963 9 following follow VBG cord-023095-4dannjjm 2963 10 anesthesia anesthesia NN cord-023095-4dannjjm 2963 11 is be VBZ cord-023095-4dannjjm 2963 12 unlikely unlikely JJ cord-023095-4dannjjm 2963 13 to to TO cord-023095-4dannjjm 2963 14 be be VB cord-023095-4dannjjm 2963 15 of of IN cord-023095-4dannjjm 2963 16 clinical clinical JJ cord-023095-4dannjjm 2963 17 relevance relevance NN cord-023095-4dannjjm 2963 18 , , , cord-023095-4dannjjm 2963 19 as as IN cord-023095-4dannjjm 2963 20 all all PDT cord-023095-4dannjjm 2963 21 the the DT cord-023095-4dannjjm 2963 22 samples sample NNS cord-023095-4dannjjm 2963 23 except except IN cord-023095-4dannjjm 2963 24 2 2 CD cord-023095-4dannjjm 2963 25 had have VBD cord-023095-4dannjjm 2963 26 a a DT cord-023095-4dannjjm 2963 27 lymphocyte lymphocyte NN cord-023095-4dannjjm 2963 28 count count NN cord-023095-4dannjjm 2963 29 that that WDT cord-023095-4dannjjm 2963 30 was be VBD cord-023095-4dannjjm 2963 31 within within IN cord-023095-4dannjjm 2963 32 the the DT cord-023095-4dannjjm 2963 33 reference reference NN cord-023095-4dannjjm 2963 34 interval interval NN cord-023095-4dannjjm 2963 35 for for IN cord-023095-4dannjjm 2963 36 cats cat NNS cord-023095-4dannjjm 2963 37 established establish VBN cord-023095-4dannjjm 2963 38 by by IN cord-023095-4dannjjm 2963 39 our -PRON- PRP$ cord-023095-4dannjjm 2963 40 laboratory laboratory NN cord-023095-4dannjjm 2963 41 . . . cord-023095-4dannjjm 2964 1 This this DT cord-023095-4dannjjm 2964 2 study study NN cord-023095-4dannjjm 2964 3 suggests suggest VBZ cord-023095-4dannjjm 2964 4 that that IN cord-023095-4dannjjm 2964 5 complete complete JJ cord-023095-4dannjjm 2964 6 blood blood NN cord-023095-4dannjjm 2964 7 counts count NNS cord-023095-4dannjjm 2964 8 performed perform VBN cord-023095-4dannjjm 2964 9 on on IN cord-023095-4dannjjm 2964 10 blood blood NN cord-023095-4dannjjm 2964 11 taken take VBN cord-023095-4dannjjm 2964 12 under under IN cord-023095-4dannjjm 2964 13 general general JJ cord-023095-4dannjjm 2964 14 anesthesia anesthesia NN cord-023095-4dannjjm 2964 15 with with IN cord-023095-4dannjjm 2964 16 this this DT cord-023095-4dannjjm 2964 17 combination combination NN cord-023095-4dannjjm 2964 18 of of IN cord-023095-4dannjjm 2964 19 anesthetic anesthetic JJ cord-023095-4dannjjm 2964 20 drugs drug NNS cord-023095-4dannjjm 2964 21 in in IN cord-023095-4dannjjm 2964 22 cats cat NNS cord-023095-4dannjjm 2964 23 should should MD cord-023095-4dannjjm 2964 24 be be VB cord-023095-4dannjjm 2964 25 interpreted interpret VBN cord-023095-4dannjjm 2964 26 cautiously cautiously RB cord-023095-4dannjjm 2964 27 in in IN cord-023095-4dannjjm 2964 28 order order NN cord-023095-4dannjjm 2964 29 not not RB cord-023095-4dannjjm 2964 30 to to TO cord-023095-4dannjjm 2964 31 make make VB cord-023095-4dannjjm 2964 32 a a DT cord-023095-4dannjjm 2964 33 false false JJ cord-023095-4dannjjm 2964 34 diagnosis diagnosis NN cord-023095-4dannjjm 2964 35 of of IN cord-023095-4dannjjm 2964 36 anemia anemia NN cord-023095-4dannjjm 2964 37 . . . cord-023095-4dannjjm 2965 1 The the DT cord-023095-4dannjjm 2965 2 mechanism mechanism NN cord-023095-4dannjjm 2965 3 responsible responsible JJ cord-023095-4dannjjm 2965 4 for for IN cord-023095-4dannjjm 2965 5 the the DT cord-023095-4dannjjm 2965 6 decrease decrease NN cord-023095-4dannjjm 2965 7 in in IN cord-023095-4dannjjm 2965 8 circulating circulate VBG cord-023095-4dannjjm 2965 9 red red JJ cord-023095-4dannjjm 2965 10 blood blood NN cord-023095-4dannjjm 2965 11 cell cell NN cord-023095-4dannjjm 2965 12 mass mass NN cord-023095-4dannjjm 2965 13 following follow VBG cord-023095-4dannjjm 2965 14 anesthesia anesthesia NN cord-023095-4dannjjm 2965 15 induction induction NN cord-023095-4dannjjm 2965 16 in in IN cord-023095-4dannjjm 2965 17 cats cat NNS cord-023095-4dannjjm 2965 18 is be VBZ cord-023095-4dannjjm 2965 19 unknown unknown JJ cord-023095-4dannjjm 2965 20 and and CC cord-023095-4dannjjm 2965 21 requires require VBZ cord-023095-4dannjjm 2965 22 further further JJ cord-023095-4dannjjm 2965 23 investigation investigation NN cord-023095-4dannjjm 2965 24 . . . cord-023095-4dannjjm 2966 1 Rivaroxaban Rivaroxaban NNP cord-023095-4dannjjm 2966 2 is be VBZ cord-023095-4dannjjm 2966 3 an an DT cord-023095-4dannjjm 2966 4 oral oral JJ cord-023095-4dannjjm 2966 5 inhibitor inhibitor NN cord-023095-4dannjjm 2966 6 of of IN cord-023095-4dannjjm 2966 7 activated activate VBN cord-023095-4dannjjm 2966 8 coagulation coagulation NN cord-023095-4dannjjm 2966 9 factor factor NN cord-023095-4dannjjm 2966 10 X X NNP cord-023095-4dannjjm 2966 11 ( ( -LRB- cord-023095-4dannjjm 2966 12 Xa Xa NNP cord-023095-4dannjjm 2966 13 ) ) -RRB- cord-023095-4dannjjm 2966 14 . . . cord-023095-4dannjjm 2967 1 It -PRON- PRP cord-023095-4dannjjm 2967 2 is be VBZ cord-023095-4dannjjm 2967 3 expected expect VBN cord-023095-4dannjjm 2967 4 to to TO cord-023095-4dannjjm 2967 5 have have VB cord-023095-4dannjjm 2967 6 similar similar JJ cord-023095-4dannjjm 2967 7 coagulation coagulation NN cord-023095-4dannjjm 2967 8 effects effect NNS cord-023095-4dannjjm 2967 9 as as IN cord-023095-4dannjjm 2967 10 low low JJ cord-023095-4dannjjm 2967 11 molecular molecular JJ cord-023095-4dannjjm 2967 12 weight weight NN cord-023095-4dannjjm 2967 13 heparin heparin NN cord-023095-4dannjjm 2967 14 , , , cord-023095-4dannjjm 2967 15 without without IN cord-023095-4dannjjm 2967 16 the the DT cord-023095-4dannjjm 2967 17 need need NN cord-023095-4dannjjm 2967 18 for for IN cord-023095-4dannjjm 2967 19 injection injection NN cord-023095-4dannjjm 2967 20 , , , cord-023095-4dannjjm 2967 21 making make VBG cord-023095-4dannjjm 2967 22 it -PRON- PRP cord-023095-4dannjjm 2967 23 an an DT cord-023095-4dannjjm 2967 24 attractive attractive JJ cord-023095-4dannjjm 2967 25 alternative alternative NN cord-023095-4dannjjm 2967 26 for for IN cord-023095-4dannjjm 2967 27 long long JJ cord-023095-4dannjjm 2967 28 - - HYPH cord-023095-4dannjjm 2967 29 term term NN cord-023095-4dannjjm 2967 30 anticoagulant anticoagulant JJ cord-023095-4dannjjm 2967 31 therapy therapy NN cord-023095-4dannjjm 2967 32 in in IN cord-023095-4dannjjm 2967 33 cats cat NNS cord-023095-4dannjjm 2967 34 . . . cord-023095-4dannjjm 2968 1 Citrated citrate VBN cord-023095-4dannjjm 2968 2 blood blood NN cord-023095-4dannjjm 2968 3 obtained obtain VBD cord-023095-4dannjjm 2968 4 from from IN cord-023095-4dannjjm 2968 5 five five CD cord-023095-4dannjjm 2968 6 healthy healthy JJ cord-023095-4dannjjm 2968 7 adult adult NN cord-023095-4dannjjm 2968 8 cats cat NNS cord-023095-4dannjjm 2968 9 was be VBD cord-023095-4dannjjm 2968 10 exposed expose VBN cord-023095-4dannjjm 2968 11 in in IN cord-023095-4dannjjm 2968 12 vitro vitro FW cord-023095-4dannjjm 2968 13 to to IN cord-023095-4dannjjm 2968 14 varying vary VBG cord-023095-4dannjjm 2968 15 concentrations concentration NNS cord-023095-4dannjjm 2968 16 of of IN cord-023095-4dannjjm 2968 17 rivaroxaban rivaroxaban NNP cord-023095-4dannjjm 2968 18 , , , cord-023095-4dannjjm 2968 19 followed follow VBN cord-023095-4dannjjm 2968 20 by by IN cord-023095-4dannjjm 2968 21 coagulation coagulation NN cord-023095-4dannjjm 2968 22 testing testing NN cord-023095-4dannjjm 2968 23 . . . cord-023095-4dannjjm 2969 1 The the DT cord-023095-4dannjjm 2969 2 rivaroxaban rivaroxaban NN cord-023095-4dannjjm 2969 3 was be VBD cord-023095-4dannjjm 2969 4 extracted extract VBN cord-023095-4dannjjm 2969 5 from from IN cord-023095-4dannjjm 2969 6 commercially commercially RB cord-023095-4dannjjm 2969 7 available available JJ cord-023095-4dannjjm 2969 8 tablets tablet NNS cord-023095-4dannjjm 2969 9 ( ( -LRB- cord-023095-4dannjjm 2969 10 Xarelto Xarelto NNP cord-023095-4dannjjm 2969 11 s s NNP cord-023095-4dannjjm 2969 12 ) ) -RRB- cord-023095-4dannjjm 2969 13 and and CC cord-023095-4dannjjm 2969 14 dissolved dissolve VBD cord-023095-4dannjjm 2969 15 in in IN cord-023095-4dannjjm 2969 16 DMSO DMSO NNP cord-023095-4dannjjm 2969 17 prior prior RB cord-023095-4dannjjm 2969 18 to to IN cord-023095-4dannjjm 2969 19 addition addition NN cord-023095-4dannjjm 2969 20 to to IN cord-023095-4dannjjm 2969 21 the the DT cord-023095-4dannjjm 2969 22 blood blood NN cord-023095-4dannjjm 2969 23 . . . cord-023095-4dannjjm 2970 1 Tests test NNS cord-023095-4dannjjm 2970 2 performed perform VBD cord-023095-4dannjjm 2970 3 included include VBD cord-023095-4dannjjm 2970 4 kaolin kaolin NN cord-023095-4dannjjm 2970 5 - - HYPH cord-023095-4dannjjm 2970 6 activated activate VBN cord-023095-4dannjjm 2970 7 thrombelastography thrombelastography NN cord-023095-4dannjjm 2970 8 ( ( -LRB- cord-023095-4dannjjm 2970 9 TEG TEG NNP cord-023095-4dannjjm 2970 10 ) ) -RRB- cord-023095-4dannjjm 2970 11 , , , cord-023095-4dannjjm 2970 12 prothrombin prothrombin JJ cord-023095-4dannjjm 2970 13 time time NN cord-023095-4dannjjm 2970 14 ( ( -LRB- cord-023095-4dannjjm 2970 15 PT PT NNP cord-023095-4dannjjm 2970 16 ) ) -RRB- cord-023095-4dannjjm 2970 17 , , , cord-023095-4dannjjm 2970 18 dilute dilute VB cord-023095-4dannjjm 2970 19 PT PT NNP cord-023095-4dannjjm 2970 20 ( ( -LRB- cord-023095-4dannjjm 2970 21 dPT dPT NNP cord-023095-4dannjjm 2970 22 ) ) -RRB- cord-023095-4dannjjm 2970 23 , , , cord-023095-4dannjjm 2970 24 activated activate VBD cord-023095-4dannjjm 2970 25 partial partial JJ cord-023095-4dannjjm 2970 26 thromboplastin thromboplastin NNP cord-023095-4dannjjm 2970 27 time time NN cord-023095-4dannjjm 2970 28 ( ( -LRB- cord-023095-4dannjjm 2970 29 aPTT aPTT NNP cord-023095-4dannjjm 2970 30 ) ) -RRB- cord-023095-4dannjjm 2970 31 , , , cord-023095-4dannjjm 2970 32 and and CC cord-023095-4dannjjm 2970 33 anti anti JJ cord-023095-4dannjjm 2970 34 - - NN cord-023095-4dannjjm 2970 35 factor factor NN cord-023095-4dannjjm 2970 36 Xa Xa NNP cord-023095-4dannjjm 2970 37 ( ( -LRB- cord-023095-4dannjjm 2970 38 aXa aXa NNP cord-023095-4dannjjm 2970 39 ) ) -RRB- cord-023095-4dannjjm 2970 40 activity activity NN cord-023095-4dannjjm 2970 41 . . . cord-023095-4dannjjm 2971 1 Dose dose JJ cord-023095-4dannjjm 2971 2 - - HYPH cord-023095-4dannjjm 2971 3 dependent dependent JJ cord-023095-4dannjjm 2971 4 prolongations prolongation NNS cord-023095-4dannjjm 2971 5 were be VBD cord-023095-4dannjjm 2971 6 seen see VBN cord-023095-4dannjjm 2971 7 in in IN cord-023095-4dannjjm 2971 8 all all DT cord-023095-4dannjjm 2971 9 coagulation coagulation NN cord-023095-4dannjjm 2971 10 parameters parameter NNS cord-023095-4dannjjm 2971 11 . . . cord-023095-4dannjjm 2972 1 Similar similar JJ cord-023095-4dannjjm 2972 2 to to IN cord-023095-4dannjjm 2972 3 human human JJ cord-023095-4dannjjm 2972 4 data datum NNS cord-023095-4dannjjm 2972 5 , , , cord-023095-4dannjjm 2972 6 therapeutic therapeutic JJ cord-023095-4dannjjm 2972 7 aXa aXa NNP cord-023095-4dannjjm 2972 8 levels level NNS cord-023095-4dannjjm 2972 9 ( ( -LRB- cord-023095-4dannjjm 2972 10 between between IN cord-023095-4dannjjm 2972 11 0.5 0.5 CD cord-023095-4dannjjm 2972 12 - - SYM cord-023095-4dannjjm 2972 13 1.0 1.0 CD cord-023095-4dannjjm 2972 14 aXa aXa NNP cord-023095-4dannjjm 2972 15 units unit NNS cord-023095-4dannjjm 2972 16 ) ) -RRB- cord-023095-4dannjjm 2972 17 were be VBD cord-023095-4dannjjm 2972 18 achieved achieve VBN cord-023095-4dannjjm 2972 19 at at IN cord-023095-4dannjjm 2972 20 in in FW cord-023095-4dannjjm 2972 21 vitro vitro FW cord-023095-4dannjjm 2972 22 concentrations concentration NNS cord-023095-4dannjjm 2972 23 between between IN cord-023095-4dannjjm 2972 24 160 160 CD cord-023095-4dannjjm 2972 25 and and CC cord-023095-4dannjjm 2972 26 220 220 CD cord-023095-4dannjjm 2972 27 mg mg NNP cord-023095-4dannjjm 2972 28 / / SYM cord-023095-4dannjjm 2972 29 L. L. NNP cord-023095-4dannjjm 2973 1 At at IN cord-023095-4dannjjm 2973 2 220 220 CD cord-023095-4dannjjm 2973 3 mg mg NNP cord-023095-4dannjjm 2973 4 / / SYM cord-023095-4dannjjm 2973 5 L L NNP cord-023095-4dannjjm 2973 6 , , , cord-023095-4dannjjm 2973 7 dPT dpt JJ cord-023095-4dannjjm 2973 8 measurements measurement NNS cord-023095-4dannjjm 2973 9 were be VBD cord-023095-4dannjjm 2973 10 clinically clinically RB cord-023095-4dannjjm 2973 11 prolonged prolong VBN cord-023095-4dannjjm 2973 12 in in IN cord-023095-4dannjjm 2973 13 all all DT cord-023095-4dannjjm 2973 14 cats cat NNS cord-023095-4dannjjm 2973 15 ( ( -LRB- cord-023095-4dannjjm 2973 16 29.2 29.2 CD cord-023095-4dannjjm 2973 17 AE AE NNP cord-023095-4dannjjm 2973 18 4 4 CD cord-023095-4dannjjm 2973 19 sec sec NNP cord-023095-4dannjjm 2973 20 vs. vs. NNP cord-023095-4dannjjm 2973 21 18.5 18.5 CD cord-023095-4dannjjm 2973 22 AE AE NNP cord-023095-4dannjjm 2973 23 0.8 0.8 CD cord-023095-4dannjjm 2973 24 sec sec NNP cord-023095-4dannjjm 2973 25 , , , cord-023095-4dannjjm 2973 26 P p NN cord-023095-4dannjjm 2973 27 5 5 CD cord-023095-4dannjjm 2973 28 0.148 0.148 CD cord-023095-4dannjjm 2973 29 ) ) -RRB- cord-023095-4dannjjm 2973 30 , , , cord-023095-4dannjjm 2973 31 while while IN cord-023095-4dannjjm 2973 32 aPTT aptt JJ cord-023095-4dannjjm 2973 33 values value NNS cord-023095-4dannjjm 2973 34 were be VBD cord-023095-4dannjjm 2973 35 only only RB cord-023095-4dannjjm 2973 36 mildly mildly RB cord-023095-4dannjjm 2973 37 prolonged prolong VBN cord-023095-4dannjjm 2973 38 from from IN cord-023095-4dannjjm 2973 39 baseline baseline JJ cord-023095-4dannjjm 2973 40 ( ( -LRB- cord-023095-4dannjjm 2973 41 21.9 21.9 CD cord-023095-4dannjjm 2973 42 AE AE NNP cord-023095-4dannjjm 2973 43 5 5 CD cord-023095-4dannjjm 2973 44 sec sec NNP cord-023095-4dannjjm 2973 45 vs. vs. NNP cord-023095-4dannjjm 2973 46 15.6 15.6 CD cord-023095-4dannjjm 2973 47 AE AE NNP cord-023095-4dannjjm 2973 48 2 2 CD cord-023095-4dannjjm 2973 49 sec sec NNP cord-023095-4dannjjm 2973 50 , , , cord-023095-4dannjjm 2973 51 P p NN cord-023095-4dannjjm 2973 52 5 5 CD cord-023095-4dannjjm 2973 53 0.07 0.07 CD cord-023095-4dannjjm 2973 54 ) ) -RRB- cord-023095-4dannjjm 2973 55 . . . cord-023095-4dannjjm 2974 1 Significant significant JJ cord-023095-4dannjjm 2974 2 prolongations prolongation NNS cord-023095-4dannjjm 2974 3 were be VBD cord-023095-4dannjjm 2974 4 seen see VBN cord-023095-4dannjjm 2974 5 in in IN cord-023095-4dannjjm 2974 6 dPT dPT NNP cord-023095-4dannjjm 2974 7 at at IN cord-023095-4dannjjm 2974 8 500 500 CD cord-023095-4dannjjm 2974 9 ( ( -LRB- cord-023095-4dannjjm 2974 10 60.4 60.4 CD cord-023095-4dannjjm 2974 11 AE AE NNP cord-023095-4dannjjm 2974 12 42 42 CD cord-023095-4dannjjm 2974 13 ec ec NNP cord-023095-4dannjjm 2974 14 , , , cord-023095-4dannjjm 2974 15 P p NN cord-023095-4dannjjm 2974 16 5 5 CD cord-023095-4dannjjm 2974 17 0.005 0.005 CD cord-023095-4dannjjm 2974 18 ) ) -RRB- cord-023095-4dannjjm 2974 19 . . . cord-023095-4dannjjm 2975 1 TEG TEG NNP cord-023095-4dannjjm 2975 2 R R NNP cord-023095-4dannjjm 2975 3 time time NN cord-023095-4dannjjm 2975 4 did do VBD cord-023095-4dannjjm 2975 5 not not RB cord-023095-4dannjjm 2975 6 prolong prolong VB cord-023095-4dannjjm 2975 7 from from IN cord-023095-4dannjjm 2975 8 baseline baseline JJ cord-023095-4dannjjm 2975 9 values value NNS cord-023095-4dannjjm 2975 10 until until IN cord-023095-4dannjjm 2975 11 concentrations concentration NNS cord-023095-4dannjjm 2975 12 of of IN cord-023095-4dannjjm 2975 13 2000 2000 CD cord-023095-4dannjjm 2975 14 mg mg NNP cord-023095-4dannjjm 2975 15 / / SYM cord-023095-4dannjjm 2975 16 L L NNP cord-023095-4dannjjm 2975 17 were be VBD cord-023095-4dannjjm 2975 18 reached reach VBN cord-023095-4dannjjm 2975 19 ( ( -LRB- cord-023095-4dannjjm 2975 20 16.0 16.0 CD cord-023095-4dannjjm 2975 21 AE AE NNP cord-023095-4dannjjm 2975 22 9 9 CD cord-023095-4dannjjm 2975 23 min min NN cord-023095-4dannjjm 2975 24 compared compare VBN cord-023095-4dannjjm 2975 25 to to IN cord-023095-4dannjjm 2975 26 3.1 3.1 CD cord-023095-4dannjjm 2975 27 AE AE NNP cord-023095-4dannjjm 2975 28 0.7 0.7 CD cord-023095-4dannjjm 2975 29 min min NN cord-023095-4dannjjm 2975 30 , , , cord-023095-4dannjjm 2975 31 P p NN cord-023095-4dannjjm 2975 32 5 5 CD cord-023095-4dannjjm 2975 33 0.006 0.006 CD cord-023095-4dannjjm 2975 34 ) ) -RRB- cord-023095-4dannjjm 2975 35 . . . cord-023095-4dannjjm 2976 1 Rivaroxaban Rivaroxaban NNP cord-023095-4dannjjm 2976 2 has have VBZ cord-023095-4dannjjm 2976 3 similar similar JJ cord-023095-4dannjjm 2976 4 coagulation coagulation NN cord-023095-4dannjjm 2976 5 effects effect NNS cord-023095-4dannjjm 2976 6 in in IN cord-023095-4dannjjm 2976 7 the the DT cord-023095-4dannjjm 2976 8 cat cat NN cord-023095-4dannjjm 2976 9 as as IN cord-023095-4dannjjm 2976 10 in in IN cord-023095-4dannjjm 2976 11 other other JJ cord-023095-4dannjjm 2976 12 species specie NNS cord-023095-4dannjjm 2976 13 and and CC cord-023095-4dannjjm 2976 14 may may MD cord-023095-4dannjjm 2976 15 play play VB cord-023095-4dannjjm 2976 16 a a DT cord-023095-4dannjjm 2976 17 role role NN cord-023095-4dannjjm 2976 18 in in IN cord-023095-4dannjjm 2976 19 feline feline JJ cord-023095-4dannjjm 2976 20 thromboprophylaxis thromboprophylaxis NN cord-023095-4dannjjm 2976 21 . . . cord-023095-4dannjjm 2977 1 Kaolinactivated Kaolinactivated NNP cord-023095-4dannjjm 2977 2 TEG TEG NNP cord-023095-4dannjjm 2977 3 does do VBZ cord-023095-4dannjjm 2977 4 not not RB cord-023095-4dannjjm 2977 5 appear appear VB cord-023095-4dannjjm 2977 6 to to TO cord-023095-4dannjjm 2977 7 be be VB cord-023095-4dannjjm 2977 8 sensitive sensitive JJ cord-023095-4dannjjm 2977 9 to to IN cord-023095-4dannjjm 2977 10 low low JJ cord-023095-4dannjjm 2977 11 concentrations concentration NNS cord-023095-4dannjjm 2977 12 of of IN cord-023095-4dannjjm 2977 13 rivaroxaban rivaroxaban NNP cord-023095-4dannjjm 2977 14 in in IN cord-023095-4dannjjm 2977 15 the the DT cord-023095-4dannjjm 2977 16 cat cat NN cord-023095-4dannjjm 2977 17 . . . cord-023095-4dannjjm 2978 1 Anticoagulated anticoagulated JJ cord-023095-4dannjjm 2978 2 blood blood NN cord-023095-4dannjjm 2978 3 is be VBZ cord-023095-4dannjjm 2978 4 required require VBN cord-023095-4dannjjm 2978 5 for for IN cord-023095-4dannjjm 2978 6 platelet platelet NN cord-023095-4dannjjm 2978 7 function function NN cord-023095-4dannjjm 2978 8 studies study NNS cord-023095-4dannjjm 2978 9 . . . cord-023095-4dannjjm 2979 1 Sodium sodium NN cord-023095-4dannjjm 2979 2 citrate citrate NN cord-023095-4dannjjm 2979 3 , , , cord-023095-4dannjjm 2979 4 a a DT cord-023095-4dannjjm 2979 5 calcium calcium NN cord-023095-4dannjjm 2979 6 chelater chelater NN cord-023095-4dannjjm 2979 7 , , , cord-023095-4dannjjm 2979 8 is be VBZ cord-023095-4dannjjm 2979 9 the the DT cord-023095-4dannjjm 2979 10 most most RBS cord-023095-4dannjjm 2979 11 commonly commonly RB cord-023095-4dannjjm 2979 12 used use VBN cord-023095-4dannjjm 2979 13 anticoagulant anticoagulant NN cord-023095-4dannjjm 2979 14 to to TO cord-023095-4dannjjm 2979 15 measure measure VB cord-023095-4dannjjm 2979 16 coagulation coagulation NN cord-023095-4dannjjm 2979 17 parameters parameter NNS cord-023095-4dannjjm 2979 18 including include VBG cord-023095-4dannjjm 2979 19 platelet platelet NN cord-023095-4dannjjm 2979 20 aggregation aggregation NN cord-023095-4dannjjm 2979 21 but but CC cord-023095-4dannjjm 2979 22 it -PRON- PRP cord-023095-4dannjjm 2979 23 may may MD cord-023095-4dannjjm 2979 24 have have VB cord-023095-4dannjjm 2979 25 a a DT cord-023095-4dannjjm 2979 26 negative negative JJ cord-023095-4dannjjm 2979 27 effect effect NN cord-023095-4dannjjm 2979 28 on on IN cord-023095-4dannjjm 2979 29 platelet platelet NN cord-023095-4dannjjm 2979 30 responsiveness responsiveness NN cord-023095-4dannjjm 2979 31 . . . cord-023095-4dannjjm 2980 1 Dogs dog NNS cord-023095-4dannjjm 2980 2 are be VBP cord-023095-4dannjjm 2980 3 generally generally RB cord-023095-4dannjjm 2980 4 considered consider VBN cord-023095-4dannjjm 2980 5 moderate moderate JJ cord-023095-4dannjjm 2980 6 responders responder NNS cord-023095-4dannjjm 2980 7 to to IN cord-023095-4dannjjm 2980 8 collagen collagen NN cord-023095-4dannjjm 2980 9 on on IN cord-023095-4dannjjm 2980 10 platelet platelet NN cord-023095-4dannjjm 2980 11 aggregation aggregation NN cord-023095-4dannjjm 2980 12 and and CC cord-023095-4dannjjm 2980 13 are be VBP cord-023095-4dannjjm 2980 14 notorious notorious JJ cord-023095-4dannjjm 2980 15 for for IN cord-023095-4dannjjm 2980 16 being be VBG cord-023095-4dannjjm 2980 17 poor poor JJ cord-023095-4dannjjm 2980 18 or or CC cord-023095-4dannjjm 2980 19 inconsistent inconsistent JJ cord-023095-4dannjjm 2980 20 responders responder NNS cord-023095-4dannjjm 2980 21 to to IN cord-023095-4dannjjm 2980 22 ADP ADP NNP cord-023095-4dannjjm 2980 23 - - HYPH cord-023095-4dannjjm 2980 24 induced induce VBN cord-023095-4dannjjm 2980 25 platelet platelet NN cord-023095-4dannjjm 2980 26 aggregation aggregation NN cord-023095-4dannjjm 2980 27 using use VBG cord-023095-4dannjjm 2980 28 citrated citrate VBN cord-023095-4dannjjm 2980 29 whole whole JJ cord-023095-4dannjjm 2980 30 blood blood NN cord-023095-4dannjjm 2980 31 . . . cord-023095-4dannjjm 2981 1 Hirudin Hirudin NNP cord-023095-4dannjjm 2981 2 , , , cord-023095-4dannjjm 2981 3 a a DT cord-023095-4dannjjm 2981 4 selective selective JJ cord-023095-4dannjjm 2981 5 thrombin thrombin JJ cord-023095-4dannjjm 2981 6 inhibitor inhibitor NN cord-023095-4dannjjm 2981 7 , , , cord-023095-4dannjjm 2981 8 can can MD cord-023095-4dannjjm 2981 9 also also RB cord-023095-4dannjjm 2981 10 be be VB cord-023095-4dannjjm 2981 11 used use VBN cord-023095-4dannjjm 2981 12 as as IN cord-023095-4dannjjm 2981 13 an an DT cord-023095-4dannjjm 2981 14 anticoagulant anticoagulant NN cord-023095-4dannjjm 2981 15 for for IN cord-023095-4dannjjm 2981 16 coagulation coagulation NN cord-023095-4dannjjm 2981 17 assays assay NNS cord-023095-4dannjjm 2981 18 and and CC cord-023095-4dannjjm 2981 19 is be VBZ cord-023095-4dannjjm 2981 20 the the DT cord-023095-4dannjjm 2981 21 anticoagulant anticoagulant NN cord-023095-4dannjjm 2981 22 of of IN cord-023095-4dannjjm 2981 23 choice choice NN cord-023095-4dannjjm 2981 24 for for IN cord-023095-4dannjjm 2981 25 certain certain JJ cord-023095-4dannjjm 2981 26 assays assay NNS cord-023095-4dannjjm 2981 27 including include VBG cord-023095-4dannjjm 2981 28 the the DT cord-023095-4dannjjm 2981 29 Multiplate Multiplate NNP cord-023095-4dannjjm 2981 30 s s POS cord-023095-4dannjjm 2981 31 platelet platelet NN cord-023095-4dannjjm 2981 32 function function NN cord-023095-4dannjjm 2981 33 analyzer analyzer NN cord-023095-4dannjjm 2981 34 . . . cord-023095-4dannjjm 2982 1 Ten ten CD cord-023095-4dannjjm 2982 2 adult adult NN cord-023095-4dannjjm 2982 3 healthy healthy JJ cord-023095-4dannjjm 2982 4 dogs dog NNS cord-023095-4dannjjm 2982 5 were be VBD cord-023095-4dannjjm 2982 6 used use VBN cord-023095-4dannjjm 2982 7 to to TO cord-023095-4dannjjm 2982 8 compare compare VB cord-023095-4dannjjm 2982 9 whole whole JJ cord-023095-4dannjjm 2982 10 blood blood NN cord-023095-4dannjjm 2982 11 platelet platelet NN cord-023095-4dannjjm 2982 12 aggregation aggregation NN cord-023095-4dannjjm 2982 13 between between IN cord-023095-4dannjjm 2982 14 citrated citrated JJ cord-023095-4dannjjm 2982 15 and and CC cord-023095-4dannjjm 2982 16 hirudinated hirudinated JJ cord-023095-4dannjjm 2982 17 blood blood NN cord-023095-4dannjjm 2982 18 samples sample NNS cord-023095-4dannjjm 2982 19 . . . cord-023095-4dannjjm 2983 1 Venous venous JJ cord-023095-4dannjjm 2983 2 blood blood NN cord-023095-4dannjjm 2983 3 was be VBD cord-023095-4dannjjm 2983 4 collected collect VBN cord-023095-4dannjjm 2983 5 atraumatically atraumatically RB cord-023095-4dannjjm 2983 6 from from IN cord-023095-4dannjjm 2983 7 the the DT cord-023095-4dannjjm 2983 8 external external JJ cord-023095-4dannjjm 2983 9 jugular jugular NN cord-023095-4dannjjm 2983 10 vein vein NN cord-023095-4dannjjm 2983 11 directly directly RB cord-023095-4dannjjm 2983 12 into into IN cord-023095-4dannjjm 2983 13 tubes tube NNS cord-023095-4dannjjm 2983 14 containing contain VBG cord-023095-4dannjjm 2983 15 3.2 3.2 CD cord-023095-4dannjjm 2983 16 % % NN cord-023095-4dannjjm 2983 17 trisodium trisodium NN cord-023095-4dannjjm 2983 18 citrate citrate NN cord-023095-4dannjjm 2983 19 or or CC cord-023095-4dannjjm 2983 20 hirudin hirudin NN cord-023095-4dannjjm 2983 21 . . . cord-023095-4dannjjm 2984 1 Whole whole JJ cord-023095-4dannjjm 2984 2 blood blood NN cord-023095-4dannjjm 2984 3 platelet platelet NN cord-023095-4dannjjm 2984 4 aggregation aggregation NN cord-023095-4dannjjm 2984 5 was be VBD cord-023095-4dannjjm 2984 6 performed perform VBN cord-023095-4dannjjm 2985 1 ( ( -LRB- cord-023095-4dannjjm 2985 2 Whole whole JJ cord-023095-4dannjjm 2985 3 - - HYPH cord-023095-4dannjjm 2985 4 Blood blood NN cord-023095-4dannjjm 2985 5 Lumi Lumi NNP cord-023095-4dannjjm 2985 6 - - HYPH cord-023095-4dannjjm 2985 7 aggregometer aggregometer NN cord-023095-4dannjjm 2985 8 , , , cord-023095-4dannjjm 2985 9 Chrono chrono NN cord-023095-4dannjjm 2985 10 - - HYPH cord-023095-4dannjjm 2985 11 log log NNP cord-023095-4dannjjm 2985 12 Corporation Corporation NNP cord-023095-4dannjjm 2985 13 , , , cord-023095-4dannjjm 2985 14 Havertown Havertown NNP cord-023095-4dannjjm 2985 15 , , , cord-023095-4dannjjm 2985 16 PA PA NNP cord-023095-4dannjjm 2985 17 , , , cord-023095-4dannjjm 2985 18 USA USA NNP cord-023095-4dannjjm 2985 19 ) ) -RRB- cord-023095-4dannjjm 2985 20 with with IN cord-023095-4dannjjm 2985 21 collagen collagen NN cord-023095-4dannjjm 2985 22 ( ( -LRB- cord-023095-4dannjjm 2985 23 5 5 CD cord-023095-4dannjjm 2985 24 mg mg NNP cord-023095-4dannjjm 2985 25 / / SYM cord-023095-4dannjjm 2985 26 ml ml NNP cord-023095-4dannjjm 2985 27 ) ) -RRB- cord-023095-4dannjjm 2985 28 and and CC cord-023095-4dannjjm 2985 29 ADP ADP NNP cord-023095-4dannjjm 2985 30 ( ( -LRB- cord-023095-4dannjjm 2985 31 10 10 CD cord-023095-4dannjjm 2985 32 mM mm CD cord-023095-4dannjjm 2985 33 ) ) -RRB- cord-023095-4dannjjm 2985 34 as as IN cord-023095-4dannjjm 2985 35 agonists agonist NNS cord-023095-4dannjjm 2985 36 . . . cord-023095-4dannjjm 2986 1 Maximal maximal JJ cord-023095-4dannjjm 2986 2 platelet platelet NN cord-023095-4dannjjm 2986 3 aggregation aggregation NN cord-023095-4dannjjm 2986 4 ( ( -LRB- cord-023095-4dannjjm 2986 5 Ohms Ohms NNP cord-023095-4dannjjm 2986 6 ) ) -RRB- cord-023095-4dannjjm 2986 7 was be VBD cord-023095-4dannjjm 2986 8 recorded record VBN cord-023095-4dannjjm 2986 9 . . . cord-023095-4dannjjm 2987 1 There there EX cord-023095-4dannjjm 2987 2 was be VBD cord-023095-4dannjjm 2987 3 a a DT cord-023095-4dannjjm 2987 4 significant significant JJ cord-023095-4dannjjm 2987 5 increase increase NN cord-023095-4dannjjm 2987 6 in in IN cord-023095-4dannjjm 2987 7 collagen collagen NN cord-023095-4dannjjm 2987 8 - - HYPH cord-023095-4dannjjm 2987 9 induced induce VBN cord-023095-4dannjjm 2987 10 platelet platelet NN cord-023095-4dannjjm 2987 11 aggregation aggregation NN cord-023095-4dannjjm 2987 12 from from IN cord-023095-4dannjjm 2987 13 the the DT cord-023095-4dannjjm 2987 14 hirudinated hirudinate VBN cord-023095-4dannjjm 2987 15 samples sample NNS cord-023095-4dannjjm 2987 16 compared compare VBN cord-023095-4dannjjm 2987 17 to to IN cord-023095-4dannjjm 2987 18 the the DT cord-023095-4dannjjm 2987 19 citrated citrate VBN cord-023095-4dannjjm 2987 20 samples sample NNS cord-023095-4dannjjm 2987 21 ( ( -LRB- cord-023095-4dannjjm 2987 22 31.2 31.2 CD cord-023095-4dannjjm 2987 23 AE AE NNP cord-023095-4dannjjm 2987 24 6.1 6.1 CD cord-023095-4dannjjm 2987 25 vs. vs. NN cord-023095-4dannjjm 2987 26 17.2 17.2 CD cord-023095-4dannjjm 2987 27 AE AE NNP cord-023095-4dannjjm 2987 28 8.6 8.6 CD cord-023095-4dannjjm 2987 29 O o NN cord-023095-4dannjjm 2987 30 , , , cord-023095-4dannjjm 2987 31 p p NN cord-023095-4dannjjm 2987 32 o o NN cord-023095-4dannjjm 2987 33 0.0005 0.0005 CD cord-023095-4dannjjm 2987 34 ) ) -RRB- cord-023095-4dannjjm 2987 35 . . . cord-023095-4dannjjm 2988 1 There there EX cord-023095-4dannjjm 2988 2 was be VBD cord-023095-4dannjjm 2988 3 also also RB cord-023095-4dannjjm 2988 4 a a DT cord-023095-4dannjjm 2988 5 significant significant JJ cord-023095-4dannjjm 2988 6 increase increase NN cord-023095-4dannjjm 2988 7 in in IN cord-023095-4dannjjm 2988 8 ADP ADP NNP cord-023095-4dannjjm 2988 9 - - HYPH cord-023095-4dannjjm 2988 10 induced induce VBN cord-023095-4dannjjm 2988 11 platelet platelet NN cord-023095-4dannjjm 2988 12 aggregation aggregation NN cord-023095-4dannjjm 2988 13 from from IN cord-023095-4dannjjm 2988 14 the the DT cord-023095-4dannjjm 2988 15 hirudinated hirudinate VBN cord-023095-4dannjjm 2988 16 samples sample NNS cord-023095-4dannjjm 2988 17 compared compare VBN cord-023095-4dannjjm 2988 18 to to IN cord-023095-4dannjjm 2988 19 the the DT cord-023095-4dannjjm 2988 20 citrated citrate VBN cord-023095-4dannjjm 2988 21 samples sample NNS cord-023095-4dannjjm 2988 22 ( ( -LRB- cord-023095-4dannjjm 2988 23 15.6 15.6 CD cord-023095-4dannjjm 2988 24 AE AE NNP cord-023095-4dannjjm 2988 25 6.0 6.0 CD cord-023095-4dannjjm 2988 26 vs. vs. IN cord-023095-4dannjjm 2988 27 2.6 2.6 CD cord-023095-4dannjjm 2988 28 AE AE NNP cord-023095-4dannjjm 2988 29 2.6 2.6 CD cord-023095-4dannjjm 2988 30 O o NN cord-023095-4dannjjm 2988 31 , , , cord-023095-4dannjjm 2988 32 p p NN cord-023095-4dannjjm 2988 33 5 5 CD cord-023095-4dannjjm 2988 34 0.0001 0.0001 CD cord-023095-4dannjjm 2988 35 ) ) -RRB- cord-023095-4dannjjm 2988 36 . . . cord-023095-4dannjjm 2989 1 The the DT cord-023095-4dannjjm 2989 2 results result NNS cord-023095-4dannjjm 2989 3 of of IN cord-023095-4dannjjm 2989 4 this this DT cord-023095-4dannjjm 2989 5 study study NN cord-023095-4dannjjm 2989 6 show show VBP cord-023095-4dannjjm 2989 7 a a DT cord-023095-4dannjjm 2989 8 significant significant JJ cord-023095-4dannjjm 2989 9 difference difference NN cord-023095-4dannjjm 2989 10 in in IN cord-023095-4dannjjm 2989 11 platelet platelet NN cord-023095-4dannjjm 2989 12 responsiveness responsiveness NN cord-023095-4dannjjm 2989 13 between between IN cord-023095-4dannjjm 2989 14 citrated citrated JJ cord-023095-4dannjjm 2989 15 and and CC cord-023095-4dannjjm 2989 16 hirudinated hirudinate VBN cord-023095-4dannjjm 2989 17 whole whole JJ cord-023095-4dannjjm 2989 18 blood blood NN cord-023095-4dannjjm 2989 19 using use VBG cord-023095-4dannjjm 2989 20 the the DT cord-023095-4dannjjm 2989 21 Chrono chrono NN cord-023095-4dannjjm 2989 22 - - HYPH cord-023095-4dannjjm 2989 23 log log NN cord-023095-4dannjjm 2989 24 impedance impedance NN cord-023095-4dannjjm 2989 25 aggregometer aggregometer NN cord-023095-4dannjjm 2989 26 . . . cord-023095-4dannjjm 2990 1 While while IN cord-023095-4dannjjm 2990 2 both both CC cord-023095-4dannjjm 2990 3 collagen collagen NN cord-023095-4dannjjm 2990 4 and and CC cord-023095-4dannjjm 2990 5 ADP ADP NNP cord-023095-4dannjjm 2990 6 - - HYPH cord-023095-4dannjjm 2990 7 induced induce VBN cord-023095-4dannjjm 2990 8 platelet platelet NN cord-023095-4dannjjm 2990 9 aggregation aggregation NN cord-023095-4dannjjm 2990 10 was be VBD cord-023095-4dannjjm 2990 11 attenuated attenuate VBN cord-023095-4dannjjm 2990 12 from from IN cord-023095-4dannjjm 2990 13 citrated citrate VBN cord-023095-4dannjjm 2990 14 blood blood NN cord-023095-4dannjjm 2990 15 samples sample NNS cord-023095-4dannjjm 2990 16 , , , cord-023095-4dannjjm 2990 17 this this DT cord-023095-4dannjjm 2990 18 was be VBD cord-023095-4dannjjm 2990 19 most most RBS cord-023095-4dannjjm 2990 20 notable notable JJ cord-023095-4dannjjm 2990 21 for for IN cord-023095-4dannjjm 2990 22 ADPinduced adpinduced JJ cord-023095-4dannjjm 2990 23 aggregation aggregation NN cord-023095-4dannjjm 2990 24 where where WRB cord-023095-4dannjjm 2990 25 almost almost RB cord-023095-4dannjjm 2990 26 all all DT cord-023095-4dannjjm 2990 27 samples sample NNS cord-023095-4dannjjm 2990 28 had have VBD cord-023095-4dannjjm 2990 29 no no DT cord-023095-4dannjjm 2990 30 objective objective JJ cord-023095-4dannjjm 2990 31 measurable measurable JJ cord-023095-4dannjjm 2990 32 platelet platelet NN cord-023095-4dannjjm 2990 33 aggregation aggregation NN cord-023095-4dannjjm 2990 34 . . . cord-023095-4dannjjm 2991 1 It -PRON- PRP cord-023095-4dannjjm 2991 2 is be VBZ cord-023095-4dannjjm 2991 3 suggested suggest VBN cord-023095-4dannjjm 2991 4 from from IN cord-023095-4dannjjm 2991 5 this this DT cord-023095-4dannjjm 2991 6 data datum NNS cord-023095-4dannjjm 2991 7 that that WDT cord-023095-4dannjjm 2991 8 future future VBP cord-023095-4dannjjm 2991 9 whole whole JJ cord-023095-4dannjjm 2991 10 blood blood NN cord-023095-4dannjjm 2991 11 platelet platelet NN cord-023095-4dannjjm 2991 12 aggregation aggregation NN cord-023095-4dannjjm 2991 13 studies study NNS cord-023095-4dannjjm 2991 14 performed perform VBN cord-023095-4dannjjm 2991 15 on on IN cord-023095-4dannjjm 2991 16 the the DT cord-023095-4dannjjm 2991 17 Chrono chrono NN cord-023095-4dannjjm 2991 18 - - HYPH cord-023095-4dannjjm 2991 19 log log NN cord-023095-4dannjjm 2991 20 impedance impedance NN cord-023095-4dannjjm 2991 21 aggregometer aggregometer NN cord-023095-4dannjjm 2991 22 should should MD cord-023095-4dannjjm 2991 23 use use VB cord-023095-4dannjjm 2991 24 hirudinated hirudinated JJ cord-023095-4dannjjm 2991 25 blood blood NN cord-023095-4dannjjm 2991 26 samples sample NNS cord-023095-4dannjjm 2991 27 although although IN cord-023095-4dannjjm 2991 28 new new JJ cord-023095-4dannjjm 2991 29 reference reference NN cord-023095-4dannjjm 2991 30 limits limit NNS cord-023095-4dannjjm 2991 31 would would MD cord-023095-4dannjjm 2991 32 need need VB cord-023095-4dannjjm 2991 33 to to TO cord-023095-4dannjjm 2991 34 be be VB cord-023095-4dannjjm 2991 35 established establish VBN cord-023095-4dannjjm 2991 36 . . . cord-023095-4dannjjm 2992 1 Low low JJ cord-023095-4dannjjm 2992 2 - - HYPH cord-023095-4dannjjm 2992 3 molecular molecular JJ cord-023095-4dannjjm 2992 4 - - HYPH cord-023095-4dannjjm 2992 5 weight weight NN cord-023095-4dannjjm 2992 6 heparin heparin NN cord-023095-4dannjjm 2992 7 ( ( -LRB- cord-023095-4dannjjm 2992 8 LMWH LMWH NNP cord-023095-4dannjjm 2992 9 ) ) -RRB- cord-023095-4dannjjm 2992 10 is be VBZ cord-023095-4dannjjm 2992 11 now now RB cord-023095-4dannjjm 2992 12 used use VBN cord-023095-4dannjjm 2992 13 to to TO cord-023095-4dannjjm 2992 14 prevent prevent VB cord-023095-4dannjjm 2992 15 thrombotic thrombotic JJ cord-023095-4dannjjm 2992 16 complications complication NNS cord-023095-4dannjjm 2992 17 in in IN cord-023095-4dannjjm 2992 18 dogs dog NNS cord-023095-4dannjjm 2992 19 . . . cord-023095-4dannjjm 2993 1 A a DT cord-023095-4dannjjm 2993 2 functional functional JJ cord-023095-4dannjjm 2993 3 assay assay NN cord-023095-4dannjjm 2993 4 such such JJ cord-023095-4dannjjm 2993 5 as as IN cord-023095-4dannjjm 2993 6 the the DT cord-023095-4dannjjm 2993 7 Calibrated Calibrated NNP cord-023095-4dannjjm 2993 8 Automated Automated NNP cord-023095-4dannjjm 2993 9 Thrombogram Thrombogram NNP cord-023095-4dannjjm 2993 10 ( ( -LRB- cord-023095-4dannjjm 2993 11 CAT cat NN cord-023095-4dannjjm 2993 12 ) ) -RRB- cord-023095-4dannjjm 2993 13 may may MD cord-023095-4dannjjm 2993 14 provide provide VB cord-023095-4dannjjm 2993 15 a a DT cord-023095-4dannjjm 2993 16 new new JJ cord-023095-4dannjjm 2993 17 approach approach NN cord-023095-4dannjjm 2993 18 for for IN cord-023095-4dannjjm 2993 19 monitoring monitor VBG cord-023095-4dannjjm 2993 20 LMWH LMWH NNP cord-023095-4dannjjm 2993 21 therapy therapy NN cord-023095-4dannjjm 2993 22 . . . cord-023095-4dannjjm 2994 1 We -PRON- PRP cord-023095-4dannjjm 2994 2 hypothesized hypothesize VBD cord-023095-4dannjjm 2994 3 that that IN cord-023095-4dannjjm 2994 4 CAT cat NN cord-023095-4dannjjm 2994 5 would would MD cord-023095-4dannjjm 2994 6 detect detect VB cord-023095-4dannjjm 2994 7 decreased decrease VBN cord-023095-4dannjjm 2994 8 endogenous endogenous JJ cord-023095-4dannjjm 2994 9 thrombin thrombin NN cord-023095-4dannjjm 2994 10 potential potential NN cord-023095-4dannjjm 2994 11 ( ( -LRB- cord-023095-4dannjjm 2994 12 ETP ETP NNP cord-023095-4dannjjm 2994 13 ) ) -RRB- cord-023095-4dannjjm 2994 14 in in IN cord-023095-4dannjjm 2994 15 healthy healthy JJ cord-023095-4dannjjm 2994 16 dogs dog NNS cord-023095-4dannjjm 2994 17 receiving receive VBG cord-023095-4dannjjm 2994 18 LMWH LMWH NNP cord-023095-4dannjjm 2994 19 ( ( -LRB- cord-023095-4dannjjm 2994 20 Fragmin Fragmin NNP cord-023095-4dannjjm 2994 21 s s NNP cord-023095-4dannjjm 2994 22 ) ) -RRB- cord-023095-4dannjjm 2994 23 . . . cord-023095-4dannjjm 2995 1 Twenty twenty CD cord-023095-4dannjjm 2995 2 - - HYPH cord-023095-4dannjjm 2995 3 four four CD cord-023095-4dannjjm 2995 4 healthy healthy JJ cord-023095-4dannjjm 2995 5 adult adult NN cord-023095-4dannjjm 2995 6 Beagles Beagles NNPS cord-023095-4dannjjm 2995 7 were be VBD cord-023095-4dannjjm 2995 8 included include VBN cord-023095-4dannjjm 2995 9 in in IN cord-023095-4dannjjm 2995 10 this this DT cord-023095-4dannjjm 2995 11 study study NN cord-023095-4dannjjm 2995 12 and and CC cord-023095-4dannjjm 2995 13 divided divide VBD cord-023095-4dannjjm 2995 14 equally equally RB cord-023095-4dannjjm 2995 15 in in IN cord-023095-4dannjjm 2995 16 four four CD cord-023095-4dannjjm 2995 17 groups group NNS cord-023095-4dannjjm 2995 18 . . . cord-023095-4dannjjm 2996 1 One one CD cord-023095-4dannjjm 2996 2 dose dose NN cord-023095-4dannjjm 2996 3 of of IN cord-023095-4dannjjm 2996 4 50 50 CD cord-023095-4dannjjm 2996 5 U u NN cord-023095-4dannjjm 2996 6 / / SYM cord-023095-4dannjjm 2996 7 kg kg NNS cord-023095-4dannjjm 2996 8 , , , cord-023095-4dannjjm 2996 9 100 100 CD cord-023095-4dannjjm 2996 10 U u NN cord-023095-4dannjjm 2996 11 / / SYM cord-023095-4dannjjm 2996 12 kg kg NNS cord-023095-4dannjjm 2996 13 or or CC cord-023095-4dannjjm 2996 14 150 150 CD cord-023095-4dannjjm 2996 15 U u NN cord-023095-4dannjjm 2996 16 / / SYM cord-023095-4dannjjm 2996 17 kg kg NNS cord-023095-4dannjjm 2996 18 of of IN cord-023095-4dannjjm 2996 19 LMWH LMWH NNP cord-023095-4dannjjm 2996 20 were be VBD cord-023095-4dannjjm 2996 21 given give VBN cord-023095-4dannjjm 2996 22 subcutaneously subcutaneously RB cord-023095-4dannjjm 2996 23 to to IN cord-023095-4dannjjm 2996 24 healthy healthy JJ cord-023095-4dannjjm 2996 25 dogs dog NNS cord-023095-4dannjjm 2996 26 and and CC cord-023095-4dannjjm 2996 27 compared compare VBN cord-023095-4dannjjm 2996 28 to to IN cord-023095-4dannjjm 2996 29 a a DT cord-023095-4dannjjm 2996 30 control control NN cord-023095-4dannjjm 2996 31 group group NN cord-023095-4dannjjm 2996 32 . . . cord-023095-4dannjjm 2997 1 Platelet platelet NN cord-023095-4dannjjm 2997 2 poor poor JJ cord-023095-4dannjjm 2997 3 plasma plasma NN cord-023095-4dannjjm 2997 4 ( ( -LRB- cord-023095-4dannjjm 2997 5 PPP PPP NNP cord-023095-4dannjjm 2997 6 ) ) -RRB- cord-023095-4dannjjm 2997 7 was be VBD cord-023095-4dannjjm 2997 8 collected collect VBN cord-023095-4dannjjm 2997 9 over over IN cord-023095-4dannjjm 2997 10 a a DT cord-023095-4dannjjm 2997 11 24 24 CD cord-023095-4dannjjm 2997 12 hour hour NN cord-023095-4dannjjm 2997 13 period period NN cord-023095-4dannjjm 2997 14 . . . cord-023095-4dannjjm 2998 1 Using use VBG cord-023095-4dannjjm 2998 2 a a DT cord-023095-4dannjjm 2998 3 repeated repeat VBN cord-023095-4dannjjm 2998 4 - - HYPH cord-023095-4dannjjm 2998 5 measure measure NN cord-023095-4dannjjm 2998 6 linear linear JJ cord-023095-4dannjjm 2998 7 model model NN cord-023095-4dannjjm 2998 8 , , , cord-023095-4dannjjm 2998 9 effect effect NN cord-023095-4dannjjm 2998 10 of of IN cord-023095-4dannjjm 2998 11 LMWH LMWH NNP cord-023095-4dannjjm 2998 12 on on IN cord-023095-4dannjjm 2998 13 ETP ETP NNP cord-023095-4dannjjm 2998 14 was be VBD cord-023095-4dannjjm 2998 15 time time NN cord-023095-4dannjjm 2998 16 and and CC cord-023095-4dannjjm 2998 17 dose dose NN cord-023095-4dannjjm 2998 18 dependent dependent JJ cord-023095-4dannjjm 2998 19 with with IN cord-023095-4dannjjm 2998 20 a a DT cord-023095-4dannjjm 2998 21 significant significant JJ cord-023095-4dannjjm 2998 22 interaction interaction NN cord-023095-4dannjjm 2998 23 ( ( -LRB- cord-023095-4dannjjm 2998 24 p p NN cord-023095-4dannjjm 2998 25 o o NN cord-023095-4dannjjm 2998 26 0.0001 0.0001 CD cord-023095-4dannjjm 2998 27 ) ) -RRB- cord-023095-4dannjjm 2998 28 . . . cord-023095-4dannjjm 2999 1 Compared compare VBN cord-023095-4dannjjm 2999 2 to to TO cord-023095-4dannjjm 2999 3 control control VB cord-023095-4dannjjm 2999 4 dogs dog NNS cord-023095-4dannjjm 2999 5 , , , cord-023095-4dannjjm 2999 6 significant significant JJ cord-023095-4dannjjm 2999 7 differences difference NNS cord-023095-4dannjjm 2999 8 were be VBD cord-023095-4dannjjm 2999 9 obtained obtain VBN cord-023095-4dannjjm 2999 10 for for IN cord-023095-4dannjjm 2999 11 group group NN cord-023095-4dannjjm 2999 12 50 50 CD cord-023095-4dannjjm 2999 13 U U NNP cord-023095-4dannjjm 2999 14 / / SYM cord-023095-4dannjjm 2999 15 kg kg NNS cord-023095-4dannjjm 2999 16 at at IN cord-023095-4dannjjm 2999 17 T60 T60 NNP cord-023095-4dannjjm 2999 18 ( ( -LRB- cord-023095-4dannjjm 2999 19 p p NN cord-023095-4dannjjm 2999 20 5 5 CD cord-023095-4dannjjm 2999 21 0.037 0.037 CD cord-023095-4dannjjm 2999 22 ) ) -RRB- cord-023095-4dannjjm 2999 23 , , , cord-023095-4dannjjm 2999 24 for for IN cord-023095-4dannjjm 2999 25 group group NN cord-023095-4dannjjm 2999 26 100 100 CD cord-023095-4dannjjm 2999 27 U U NNP cord-023095-4dannjjm 2999 28 / / SYM cord-023095-4dannjjm 2999 29 kg kg NNS cord-023095-4dannjjm 2999 30 at at IN cord-023095-4dannjjm 2999 31 T15 T15 NNP cord-023095-4dannjjm 2999 32 ( ( -LRB- cord-023095-4dannjjm 2999 33 p p NN cord-023095-4dannjjm 2999 34 5 5 CD cord-023095-4dannjjm 2999 35 0.013 0.013 CD cord-023095-4dannjjm 2999 36 ) ) -RRB- cord-023095-4dannjjm 2999 37 and and CC cord-023095-4dannjjm 2999 38 between between IN cord-023095-4dannjjm 2999 39 T30-T240 T30-T240 NNP cord-023095-4dannjjm 2999 40 minutes minute NNS cord-023095-4dannjjm 2999 41 ( ( -LRB- cord-023095-4dannjjm 2999 42 p p NN cord-023095-4dannjjm 2999 43 o o NN cord-023095-4dannjjm 2999 44 0.0001 0.0001 CD cord-023095-4dannjjm 2999 45 ) ) -RRB- cord-023095-4dannjjm 2999 46 respectively respectively RB cord-023095-4dannjjm 2999 47 , , , cord-023095-4dannjjm 2999 48 and and CC cord-023095-4dannjjm 2999 49 for for IN cord-023095-4dannjjm 2999 50 group group NN cord-023095-4dannjjm 2999 51 150 150 CD cord-023095-4dannjjm 2999 52 U/ U/ NNS cord-023095-4dannjjm 2999 53 at at IN cord-023095-4dannjjm 2999 54 T15 T15 NNP cord-023095-4dannjjm 2999 55 ( ( -LRB- cord-023095-4dannjjm 2999 56 p p NN cord-023095-4dannjjm 2999 57 5 5 CD cord-023095-4dannjjm 2999 58 0.011 0.011 CD cord-023095-4dannjjm 2999 59 ) ) -RRB- cord-023095-4dannjjm 2999 60 , , , cord-023095-4dannjjm 2999 61 between between IN cord-023095-4dannjjm 2999 62 T30-T300 T30-T300 NNP cord-023095-4dannjjm 2999 63 minutes minute NNS cord-023095-4dannjjm 2999 64 ( ( -LRB- cord-023095-4dannjjm 2999 65 p p NN cord-023095-4dannjjm 2999 66 o o NN cord-023095-4dannjjm 2999 67 0.0001 0.0001 CD cord-023095-4dannjjm 2999 68 ) ) -RRB- cord-023095-4dannjjm 2999 69 respectively respectively RB cord-023095-4dannjjm 2999 70 and and CC cord-023095-4dannjjm 2999 71 at at IN cord-023095-4dannjjm 2999 72 T360 t360 CD cord-023095-4dannjjm 2999 73 ( ( -LRB- cord-023095-4dannjjm 2999 74 p p NN cord-023095-4dannjjm 2999 75 5 5 CD cord-023095-4dannjjm 2999 76 0.004 0.004 CD cord-023095-4dannjjm 3000 1 The the DT cord-023095-4dannjjm 3000 2 CAT cat NN cord-023095-4dannjjm 3000 3 assay assay NN cord-023095-4dannjjm 3000 4 can can MD cord-023095-4dannjjm 3000 5 be be VB cord-023095-4dannjjm 3000 6 employed employ VBN cord-023095-4dannjjm 3000 7 to to TO cord-023095-4dannjjm 3000 8 measure measure VB cord-023095-4dannjjm 3000 9 the the DT cord-023095-4dannjjm 3000 10 effects effect NNS cord-023095-4dannjjm 3000 11 of of IN cord-023095-4dannjjm 3000 12 LMWH LMWH NNP cord-023095-4dannjjm 3000 13 at at IN cord-023095-4dannjjm 3000 14 different different JJ cord-023095-4dannjjm 3000 15 doses dose NNS cord-023095-4dannjjm 3000 16 in in IN cord-023095-4dannjjm 3000 17 healthy healthy JJ cord-023095-4dannjjm 3000 18 dogs dog NNS cord-023095-4dannjjm 3000 19 , , , cord-023095-4dannjjm 3000 20 resulting result VBG cord-023095-4dannjjm 3000 21 in in IN cord-023095-4dannjjm 3000 22 significant significant JJ cord-023095-4dannjjm 3000 23 time time NN cord-023095-4dannjjm 3000 24 and and CC cord-023095-4dannjjm 3000 25 dose dose NN cord-023095-4dannjjm 3000 26 - - HYPH cord-023095-4dannjjm 3000 27 dependent dependent JJ cord-023095-4dannjjm 3000 28 decreases decrease NNS cord-023095-4dannjjm 3000 29 in in IN cord-023095-4dannjjm 3000 30 ETP ETP NNP cord-023095-4dannjjm 3000 31 and and CC cord-023095-4dannjjm 3000 32 warrants warrant NNS cord-023095-4dannjjm 3000 33 further further JJ cord-023095-4dannjjm 3000 34 investigation investigation NN cord-023095-4dannjjm 3000 35 as as IN cord-023095-4dannjjm 3000 36 a a DT cord-023095-4dannjjm 3000 37 tool tool NN cord-023095-4dannjjm 3000 38 for for IN cord-023095-4dannjjm 3000 39 monitoring monitor VBG cord-023095-4dannjjm 3000 40 LMWH LMWH NNP cord-023095-4dannjjm 3000 41 therapy therapy NN cord-023095-4dannjjm 3000 42 in in IN cord-023095-4dannjjm 3000 43 dogs dog NNS cord-023095-4dannjjm 3000 44 . . . cord-023095-4dannjjm 3001 1 The the DT cord-023095-4dannjjm 3001 2 purpose purpose NN cord-023095-4dannjjm 3001 3 of of IN cord-023095-4dannjjm 3001 4 this this DT cord-023095-4dannjjm 3001 5 study study NN cord-023095-4dannjjm 3001 6 was be VBD cord-023095-4dannjjm 3001 7 to to TO cord-023095-4dannjjm 3001 8 determine determine VB cord-023095-4dannjjm 3001 9 the the DT cord-023095-4dannjjm 3001 10 effects effect NNS cord-023095-4dannjjm 3001 11 of of IN cord-023095-4dannjjm 3001 12 prednisone prednisone NN cord-023095-4dannjjm 3001 13 and and CC cord-023095-4dannjjm 3001 14 prednisone prednisone NNP cord-023095-4dannjjm 3001 15 plus plus CC cord-023095-4dannjjm 3001 16 ultralow ultralow JJ cord-023095-4dannjjm 3001 17 - - HYPH cord-023095-4dannjjm 3001 18 dose dose NN cord-023095-4dannjjm 3001 19 aspirin aspirin NN cord-023095-4dannjjm 3001 20 on on IN cord-023095-4dannjjm 3001 21 coagulation coagulation NN cord-023095-4dannjjm 3001 22 parameters parameter NNS cord-023095-4dannjjm 3001 23 in in IN cord-023095-4dannjjm 3001 24 healthy healthy JJ cord-023095-4dannjjm 3001 25 dogs dog NNS cord-023095-4dannjjm 3001 26 , , , cord-023095-4dannjjm 3001 27 with with IN cord-023095-4dannjjm 3001 28 an an DT cord-023095-4dannjjm 3001 29 emphasis emphasis NN cord-023095-4dannjjm 3001 30 on on IN cord-023095-4dannjjm 3001 31 thromboelastography thromboelastography NNP cord-023095-4dannjjm 3001 32 ( ( -LRB- cord-023095-4dannjjm 3001 33 TEG TEG NNP cord-023095-4dannjjm 3001 34 ) ) -RRB- cord-023095-4dannjjm 3001 35 . . . cord-023095-4dannjjm 3002 1 This this DT cord-023095-4dannjjm 3002 2 was be VBD cord-023095-4dannjjm 3002 3 a a DT cord-023095-4dannjjm 3002 4 prospective prospective JJ cord-023095-4dannjjm 3002 5 , , , cord-023095-4dannjjm 3002 6 randomized randomized JJ cord-023095-4dannjjm 3002 7 , , , cord-023095-4dannjjm 3002 8 blinded blinded JJ cord-023095-4dannjjm 3002 9 study study NN cord-023095-4dannjjm 3002 10 utilizing utilize VBG cord-023095-4dannjjm 3002 11 fourteen fourteen CD cord-023095-4dannjjm 3002 12 dogs dog NNS cord-023095-4dannjjm 3002 13 determined determine VBN cord-023095-4dannjjm 3002 14 to to TO cord-023095-4dannjjm 3002 15 be be VB cord-023095-4dannjjm 3002 16 healthy healthy JJ cord-023095-4dannjjm 3002 17 based base VBN cord-023095-4dannjjm 3002 18 on on IN cord-023095-4dannjjm 3002 19 normal normal JJ cord-023095-4dannjjm 3002 20 physical physical JJ cord-023095-4dannjjm 3002 21 examination examination NN cord-023095-4dannjjm 3002 22 , , , cord-023095-4dannjjm 3002 23 complete complete JJ cord-023095-4dannjjm 3002 24 blood blood NN cord-023095-4dannjjm 3002 25 count count NN cord-023095-4dannjjm 3002 26 , , , cord-023095-4dannjjm 3002 27 biochemistry biochemistry NN cord-023095-4dannjjm 3002 28 , , , cord-023095-4dannjjm 3002 29 urinalysis urinalysis NN cord-023095-4dannjjm 3002 30 , , , cord-023095-4dannjjm 3002 31 and and CC cord-023095-4dannjjm 3002 32 fecal fecal JJ cord-023095-4dannjjm 3002 33 floatation floatation NN cord-023095-4dannjjm 3002 34 . . . cord-023095-4dannjjm 3003 1 Dogs dog NNS cord-023095-4dannjjm 3003 2 were be VBD cord-023095-4dannjjm 3003 3 evenly evenly RB cord-023095-4dannjjm 3003 4 divided divide VBN cord-023095-4dannjjm 3003 5 into into IN cord-023095-4dannjjm 3003 6 either either CC cord-023095-4dannjjm 3003 7 prednisone prednisone NNP cord-023095-4dannjjm 3003 8 plus plus CC cord-023095-4dannjjm 3003 9 aspirin aspirin NNP cord-023095-4dannjjm 3003 10 ( ( -LRB- cord-023095-4dannjjm 3003 11 PA PA NNP cord-023095-4dannjjm 3003 12 ) ) -RRB- cord-023095-4dannjjm 3003 13 or or CC cord-023095-4dannjjm 3003 14 prednisone prednisone NNP cord-023095-4dannjjm 3003 15 plus plus CC cord-023095-4dannjjm 3003 16 placebo placebo NN cord-023095-4dannjjm 3003 17 ( ( -LRB- cord-023095-4dannjjm 3003 18 PP PP NNP cord-023095-4dannjjm 3003 19 ) ) -RRB- cord-023095-4dannjjm 3003 20 groups group NNS cord-023095-4dannjjm 3003 21 . . . cord-023095-4dannjjm 3004 1 Baseline baseline JJ cord-023095-4dannjjm 3004 2 values value NNS cord-023095-4dannjjm 3004 3 for for IN cord-023095-4dannjjm 3004 4 TEG TEG NNP cord-023095-4dannjjm 3004 5 parameters parameter NNS cord-023095-4dannjjm 3004 6 ( ( -LRB- cord-023095-4dannjjm 3005 1 R r NN cord-023095-4dannjjm 3005 2 , , , cord-023095-4dannjjm 3005 3 K K NNP cord-023095-4dannjjm 3005 4 , , , cord-023095-4dannjjm 3005 5 angle angle NN cord-023095-4dannjjm 3005 6 , , , cord-023095-4dannjjm 3005 7 MA MA NNP cord-023095-4dannjjm 3005 8 , , , cord-023095-4dannjjm 3005 9 Ly30 Ly30 NNP cord-023095-4dannjjm 3005 10 , , , cord-023095-4dannjjm 3005 11 Ly60 Ly60 NNP cord-023095-4dannjjm 3005 12 , , , cord-023095-4dannjjm 3005 13 G G NNP cord-023095-4dannjjm 3005 14 , , , cord-023095-4dannjjm 3005 15 CI CI NNP cord-023095-4dannjjm 3005 16 ) ) -RRB- cord-023095-4dannjjm 3005 17 were be VBD cord-023095-4dannjjm 3005 18 measured measure VBN cord-023095-4dannjjm 3005 19 twice twice RB cord-023095-4dannjjm 3005 20 two two CD cord-023095-4dannjjm 3005 21 days day NNS cord-023095-4dannjjm 3005 22 apart apart RB cord-023095-4dannjjm 3005 23 , , , cord-023095-4dannjjm 3005 24 and and CC cord-023095-4dannjjm 3005 25 thrombin thrombin NN cord-023095-4dannjjm 3005 26 - - HYPH cord-023095-4dannjjm 3005 27 antithrombin antithrombin NN cord-023095-4dannjjm 3005 28 complexes complex NNS cord-023095-4dannjjm 3005 29 ( ( -LRB- cord-023095-4dannjjm 3005 30 TAT TAT NNP cord-023095-4dannjjm 3005 31 ) ) -RRB- cord-023095-4dannjjm 3005 32 , , , cord-023095-4dannjjm 3005 33 and and CC cord-023095-4dannjjm 3005 34 traditional traditional JJ cord-023095-4dannjjm 3005 35 coagulation coagulation NN cord-023095-4dannjjm 3005 36 parameters parameter NNS cord-023095-4dannjjm 3005 37 ( ( -LRB- cord-023095-4dannjjm 3005 38 prothrombin prothrombin JJ cord-023095-4dannjjm 3005 39 time time NN cord-023095-4dannjjm 3005 40 , , , cord-023095-4dannjjm 3005 41 activated activate VBD cord-023095-4dannjjm 3005 42 partial partial JJ cord-023095-4dannjjm 3005 43 thromboplastin thromboplastin NNP cord-023095-4dannjjm 3005 44 time time NN cord-023095-4dannjjm 3005 45 , , , cord-023095-4dannjjm 3005 46 d d NN cord-023095-4dannjjm 3005 47 - - HYPH cord-023095-4dannjjm 3005 48 dimer dimer JJ cord-023095-4dannjjm 3005 49 , , , cord-023095-4dannjjm 3005 50 antithrombin antithrombin NN cord-023095-4dannjjm 3005 51 ( ( -LRB- cord-023095-4dannjjm 3005 52 AT AT NNP cord-023095-4dannjjm 3005 53 ) ) -RRB- cord-023095-4dannjjm 3005 54 , , , cord-023095-4dannjjm 3005 55 fibrinogen fibrinogen NN cord-023095-4dannjjm 3005 56 ) ) -RRB- cord-023095-4dannjjm 3005 57 were be VBD cord-023095-4dannjjm 3005 58 measured measure VBN cord-023095-4dannjjm 3005 59 once once RB cord-023095-4dannjjm 3005 60 . . . cord-023095-4dannjjm 3006 1 Each each DT cord-023095-4dannjjm 3006 2 dog dog NN cord-023095-4dannjjm 3006 3 received receive VBD cord-023095-4dannjjm 3006 4 2 2 CD cord-023095-4dannjjm 3006 5 mg mg NNP cord-023095-4dannjjm 3006 6 / / SYM cord-023095-4dannjjm 3006 7 kg/ kg/ NNP cord-023095-4dannjjm 3006 8 day day NN cord-023095-4dannjjm 3006 9 of of IN cord-023095-4dannjjm 3006 10 prednisone prednisone NNP cord-023095-4dannjjm 3006 11 , , , cord-023095-4dannjjm 3006 12 and and CC cord-023095-4dannjjm 3006 13 either either RB cord-023095-4dannjjm 3006 14 0.5 0.5 CD cord-023095-4dannjjm 3006 15 mg mg NNP cord-023095-4dannjjm 3006 16 / / SYM cord-023095-4dannjjm 3006 17 kg kg NNP cord-023095-4dannjjm 3006 18 / / SYM cord-023095-4dannjjm 3006 19 day day NN cord-023095-4dannjjm 3006 20 of of IN cord-023095-4dannjjm 3006 21 aspirin aspirin NN cord-023095-4dannjjm 3006 22 ( ( -LRB- cord-023095-4dannjjm 3006 23 PA PA NNP cord-023095-4dannjjm 3006 24 group group NN cord-023095-4dannjjm 3006 25 ) ) -RRB- cord-023095-4dannjjm 3006 26 or or CC cord-023095-4dannjjm 3006 27 placebo placebo NN cord-023095-4dannjjm 3006 28 ( ( -LRB- cord-023095-4dannjjm 3006 29 PP PP NNP cord-023095-4dannjjm 3006 30 group group NN cord-023095-4dannjjm 3006 31 ) ) -RRB- cord-023095-4dannjjm 3006 32 for for IN cord-023095-4dannjjm 3006 33 14 14 CD cord-023095-4dannjjm 3006 34 days day NNS cord-023095-4dannjjm 3006 35 . . . cord-023095-4dannjjm 3007 1 A a DT cord-023095-4dannjjm 3007 2 complete complete JJ cord-023095-4dannjjm 3007 3 blood blood NN cord-023095-4dannjjm 3007 4 count count NN cord-023095-4dannjjm 3007 5 , , , cord-023095-4dannjjm 3007 6 biochemistry biochemistry NN cord-023095-4dannjjm 3007 7 profile profile NN cord-023095-4dannjjm 3007 8 , , , cord-023095-4dannjjm 3007 9 TEG TEG NNP cord-023095-4dannjjm 3007 10 , , , cord-023095-4dannjjm 3007 11 TAT TAT NNP cord-023095-4dannjjm 3007 12 , , , cord-023095-4dannjjm 3007 13 and and CC cord-023095-4dannjjm 3007 14 traditional traditional JJ cord-023095-4dannjjm 3007 15 coagulation coagulation NN cord-023095-4dannjjm 3007 16 parameters parameter NNS cord-023095-4dannjjm 3007 17 were be VBD cord-023095-4dannjjm 3007 18 then then RB cord-023095-4dannjjm 3007 19 repeated repeat VBN cord-023095-4dannjjm 3007 20 on on IN cord-023095-4dannjjm 3007 21 each each DT cord-023095-4dannjjm 3007 22 dog dog NN cord-023095-4dannjjm 3007 23 . . . cord-023095-4dannjjm 3008 1 Day day NN cord-023095-4dannjjm 3008 2 to to IN cord-023095-4dannjjm 3008 3 day day NN cord-023095-4dannjjm 3008 4 variation variation NN cord-023095-4dannjjm 3008 5 was be VBD cord-023095-4dannjjm 3008 6 calculated calculate VBN cord-023095-4dannjjm 3008 7 for for IN cord-023095-4dannjjm 3008 8 the the DT cord-023095-4dannjjm 3008 9 TEG TEG NNP cord-023095-4dannjjm 3008 10 parameters parameter NNS cord-023095-4dannjjm 3008 11 using use VBG cord-023095-4dannjjm 3008 12 the the DT cord-023095-4dannjjm 3008 13 two two CD cord-023095-4dannjjm 3008 14 baseline baseline JJ cord-023095-4dannjjm 3008 15 measurements measurement NNS cord-023095-4dannjjm 3008 16 . . . cord-023095-4dannjjm 3009 1 The the DT cord-023095-4dannjjm 3009 2 change change NN cord-023095-4dannjjm 3009 3 from from IN cord-023095-4dannjjm 3009 4 baseline baseline NN cord-023095-4dannjjm 3009 5 between between IN cord-023095-4dannjjm 3009 6 and and CC cord-023095-4dannjjm 3009 7 within within IN cord-023095-4dannjjm 3009 8 each each DT cord-023095-4dannjjm 3009 9 group group NN cord-023095-4dannjjm 3009 10 were be VBD cord-023095-4dannjjm 3009 11 compared compare VBN cord-023095-4dannjjm 3009 12 using use VBG cord-023095-4dannjjm 3009 13 t t NN cord-023095-4dannjjm 3009 14 - - HYPH cord-023095-4dannjjm 3009 15 tests test NNS cord-023095-4dannjjm 3009 16 , , , cord-023095-4dannjjm 3009 17 or or CC cord-023095-4dannjjm 3009 18 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 3009 19 2 2 CD cord-023095-4dannjjm 3009 20 sample sample NN cord-023095-4dannjjm 3009 21 test test NN cord-023095-4dannjjm 3009 22 where where WRB cord-023095-4dannjjm 3009 23 appropriate appropriate JJ cord-023095-4dannjjm 3009 24 , , , cord-023095-4dannjjm 3009 25 for for IN cord-023095-4dannjjm 3009 26 TEG TEG NNP cord-023095-4dannjjm 3009 27 , , , cord-023095-4dannjjm 3009 28 TAT TAT NNP cord-023095-4dannjjm 3009 29 , , , cord-023095-4dannjjm 3009 30 traditional traditional JJ cord-023095-4dannjjm 3009 31 coagulation coagulation NN cord-023095-4dannjjm 3009 32 parameters parameter NNS cord-023095-4dannjjm 3009 33 , , , cord-023095-4dannjjm 3009 34 and and CC cord-023095-4dannjjm 3009 35 hematocrit hematocrit NN cord-023095-4dannjjm 3009 36 . . . cord-023095-4dannjjm 3010 1 Day day NN cord-023095-4dannjjm 3010 2 to to IN cord-023095-4dannjjm 3010 3 day day NN cord-023095-4dannjjm 3010 4 variation variation NN cord-023095-4dannjjm 3010 5 in in IN cord-023095-4dannjjm 3010 6 TEG TEG NNP cord-023095-4dannjjm 3010 7 was be VBD cord-023095-4dannjjm 3010 8 acceptable acceptable JJ cord-023095-4dannjjm 3010 9 ( ( -LRB- cord-023095-4dannjjm 3010 10 10 10 CD cord-023095-4dannjjm 3010 11 % % NN cord-023095-4dannjjm 3010 12 ) ) -RRB- cord-023095-4dannjjm 3010 13 for for IN cord-023095-4dannjjm 3010 14 MA MA NNP cord-023095-4dannjjm 3010 15 , , , cord-023095-4dannjjm 3010 16 G G NNP cord-023095-4dannjjm 3010 17 , , , cord-023095-4dannjjm 3010 18 and and CC cord-023095-4dannjjm 3010 19 angle angle NN cord-023095-4dannjjm 3010 20 , , , cord-023095-4dannjjm 3010 21 unacceptable unacceptable JJ cord-023095-4dannjjm 3010 22 ( ( -LRB- cord-023095-4dannjjm 3010 23 4 4 CD cord-023095-4dannjjm 3010 24 10 10 CD cord-023095-4dannjjm 3010 25 % % NN cord-023095-4dannjjm 3010 26 ) ) -RRB- cord-023095-4dannjjm 3010 27 for for IN cord-023095-4dannjjm 3010 28 R r NN cord-023095-4dannjjm 3010 29 , , , cord-023095-4dannjjm 3010 30 K K NNP cord-023095-4dannjjm 3010 31 , , , cord-023095-4dannjjm 3010 32 Ly30 Ly30 NNP cord-023095-4dannjjm 3010 33 and and CC cord-023095-4dannjjm 3010 34 Ly60 Ly60 NNP cord-023095-4dannjjm 3010 35 , , , cord-023095-4dannjjm 3010 36 and and CC cord-023095-4dannjjm 3010 37 not not RB cord-023095-4dannjjm 3010 38 meaningful meaningful JJ cord-023095-4dannjjm 3010 39 for for IN cord-023095-4dannjjm 3010 40 CI CI NNP cord-023095-4dannjjm 3010 41 . . . cord-023095-4dannjjm 3011 1 Within within IN cord-023095-4dannjjm 3011 2 both both DT cord-023095-4dannjjm 3011 3 groups group NNS cord-023095-4dannjjm 3011 4 , , , cord-023095-4dannjjm 3011 5 MA MA NNP cord-023095-4dannjjm 3011 6 , , , cord-023095-4dannjjm 3011 7 G G NNP cord-023095-4dannjjm 3011 8 , , , cord-023095-4dannjjm 3011 9 CI CI NNP cord-023095-4dannjjm 3011 10 and and CC cord-023095-4dannjjm 3011 11 fibrinogen fibrinogen NN cord-023095-4dannjjm 3011 12 significantly significantly RB cord-023095-4dannjjm 3011 13 increased increase VBD cord-023095-4dannjjm 3011 14 from from IN cord-023095-4dannjjm 3011 15 baseline baseline NN cord-023095-4dannjjm 3011 16 ( ( -LRB- cord-023095-4dannjjm 3011 17 p p NN cord-023095-4dannjjm 3011 18 o o NN cord-023095-4dannjjm 3011 19 0.05 0.05 CD cord-023095-4dannjjm 3011 20 ) ) -RRB- cord-023095-4dannjjm 3011 21 . . . cord-023095-4dannjjm 3012 1 Within within IN cord-023095-4dannjjm 3012 2 both both DT cord-023095-4dannjjm 3012 3 groups group NNS cord-023095-4dannjjm 3012 4 , , , cord-023095-4dannjjm 3012 5 Ly30 Ly30 NNP cord-023095-4dannjjm 3012 6 and and CC cord-023095-4dannjjm 3012 7 AT at IN cord-023095-4dannjjm 3012 8 significantly significantly RB cord-023095-4dannjjm 3012 9 decreased decrease VBD cord-023095-4dannjjm 3012 10 from from IN cord-023095-4dannjjm 3012 11 baseline baseline NN cord-023095-4dannjjm 3012 12 ( ( -LRB- cord-023095-4dannjjm 3012 13 p p NN cord-023095-4dannjjm 3012 14 o o NN cord-023095-4dannjjm 3012 15 0.05 0.05 CD cord-023095-4dannjjm 3012 16 ) ) -RRB- cord-023095-4dannjjm 3012 17 . . . cord-023095-4dannjjm 3013 1 For for IN cord-023095-4dannjjm 3013 2 the the DT cord-023095-4dannjjm 3013 3 PP PP NNP cord-023095-4dannjjm 3013 4 group group NN cord-023095-4dannjjm 3013 5 , , , cord-023095-4dannjjm 3013 6 Ly60 Ly60 NNP cord-023095-4dannjjm 3013 7 significantly significantly RB cord-023095-4dannjjm 3013 8 decreased decrease VBD cord-023095-4dannjjm 3013 9 from from IN cord-023095-4dannjjm 3013 10 baseline baseline NN cord-023095-4dannjjm 3013 11 ( ( -LRB- cord-023095-4dannjjm 3013 12 p p NN cord-023095-4dannjjm 3013 13 5 5 CD cord-023095-4dannjjm 3013 14 0.03 0.03 CD cord-023095-4dannjjm 3013 15 ) ) -RRB- cord-023095-4dannjjm 3013 16 , , , cord-023095-4dannjjm 3013 17 and and CC cord-023095-4dannjjm 3013 18 approached approach VBD cord-023095-4dannjjm 3013 19 significance significance NN cord-023095-4dannjjm 3013 20 for for IN cord-023095-4dannjjm 3013 21 the the DT cord-023095-4dannjjm 3013 22 PA PA NNP cord-023095-4dannjjm 3013 23 group group NN cord-023095-4dannjjm 3013 24 ( ( -LRB- cord-023095-4dannjjm 3013 25 p p NN cord-023095-4dannjjm 3013 26 5 5 CD cord-023095-4dannjjm 3013 27 0.0504 0.0504 CD cord-023095-4dannjjm 3013 28 ) ) -RRB- cord-023095-4dannjjm 3013 29 . . . cord-023095-4dannjjm 3014 1 All all DT cord-023095-4dannjjm 3014 2 other other JJ cord-023095-4dannjjm 3014 3 within within IN cord-023095-4dannjjm 3014 4 group group NN cord-023095-4dannjjm 3014 5 changes change NNS cord-023095-4dannjjm 3014 6 from from IN cord-023095-4dannjjm 3014 7 baseline baseline NN cord-023095-4dannjjm 3014 8 were be VBD cord-023095-4dannjjm 3014 9 not not RB cord-023095-4dannjjm 3014 10 statistically statistically RB cord-023095-4dannjjm 3014 11 significant significant JJ cord-023095-4dannjjm 3014 12 ( ( -LRB- cord-023095-4dannjjm 3014 13 p p NN cord-023095-4dannjjm 3014 14 - - HYPH cord-023095-4dannjjm 3014 15 values value NNS cord-023095-4dannjjm 3014 16 4 4 CD cord-023095-4dannjjm 3014 17 0.05 0.05 CD cord-023095-4dannjjm 3014 18 ) ) -RRB- cord-023095-4dannjjm 3014 19 . . . cord-023095-4dannjjm 3015 1 For for IN cord-023095-4dannjjm 3015 2 all all DT cord-023095-4dannjjm 3015 3 parameters parameter NNS cord-023095-4dannjjm 3015 4 , , , cord-023095-4dannjjm 3015 5 there there EX cord-023095-4dannjjm 3015 6 was be VBD cord-023095-4dannjjm 3015 7 no no DT cord-023095-4dannjjm 3015 8 difference difference NN cord-023095-4dannjjm 3015 9 between between IN cord-023095-4dannjjm 3015 10 groups group NNS cord-023095-4dannjjm 3015 11 for for IN cord-023095-4dannjjm 3015 12 change change NN cord-023095-4dannjjm 3015 13 from from IN cord-023095-4dannjjm 3015 14 baseline baseline NN cord-023095-4dannjjm 3015 15 ( ( -LRB- cord-023095-4dannjjm 3015 16 p p IN cord-023095-4dannjjm 3015 17 values value NNS cord-023095-4dannjjm 3015 18 4 4 CD cord-023095-4dannjjm 3015 19 0.05 0.05 CD cord-023095-4dannjjm 3015 20 ) ) -RRB- cord-023095-4dannjjm 3015 21 . . . cord-023095-4dannjjm 3016 1 Day day NN cord-023095-4dannjjm 3016 2 to to IN cord-023095-4dannjjm 3016 3 day day NN cord-023095-4dannjjm 3016 4 variation variation NN cord-023095-4dannjjm 3016 5 in in IN cord-023095-4dannjjm 3016 6 some some DT cord-023095-4dannjjm 3016 7 TEG TEG NNP cord-023095-4dannjjm 3016 8 parameters parameter NNS cord-023095-4dannjjm 3016 9 is be VBZ cord-023095-4dannjjm 3016 10 high high JJ cord-023095-4dannjjm 3016 11 and and CC cord-023095-4dannjjm 3016 12 may may MD cord-023095-4dannjjm 3016 13 preclude preclude VB cord-023095-4dannjjm 3016 14 their -PRON- PRP$ cord-023095-4dannjjm 3016 15 clinical clinical JJ cord-023095-4dannjjm 3016 16 utility utility NN cord-023095-4dannjjm 3016 17 . . . cord-023095-4dannjjm 3017 1 Prednisone Prednisone NNP cord-023095-4dannjjm 3017 2 causes cause VBZ cord-023095-4dannjjm 3017 3 hypercoagulability hypercoagulability NN cord-023095-4dannjjm 3017 4 in in IN cord-023095-4dannjjm 3017 5 healthy healthy JJ cord-023095-4dannjjm 3017 6 dogs dog NNS cord-023095-4dannjjm 3017 7 based base VBN cord-023095-4dannjjm 3017 8 on on IN cord-023095-4dannjjm 3017 9 increased increase VBN cord-023095-4dannjjm 3017 10 G g NN cord-023095-4dannjjm 3017 11 , , , cord-023095-4dannjjm 3017 12 MA MA NNP cord-023095-4dannjjm 3017 13 , , , cord-023095-4dannjjm 3017 14 and and CC cord-023095-4dannjjm 3017 15 CI CI NNP cord-023095-4dannjjm 3017 16 . . . cord-023095-4dannjjm 3018 1 The the DT cord-023095-4dannjjm 3018 2 addition addition NN cord-023095-4dannjjm 3018 3 of of IN cord-023095-4dannjjm 3018 4 ultra ultra JJ cord-023095-4dannjjm 3018 5 - - JJ cord-023095-4dannjjm 3018 6 low low JJ cord-023095-4dannjjm 3018 7 dose dose NN cord-023095-4dannjjm 3018 8 aspirin aspirin NN cord-023095-4dannjjm 3018 9 to to IN cord-023095-4dannjjm 3018 10 prednisone prednisone NNP cord-023095-4dannjjm 3018 11 has have VBZ cord-023095-4dannjjm 3018 12 no no DT cord-023095-4dannjjm 3018 13 effect effect NN cord-023095-4dannjjm 3018 14 on on IN cord-023095-4dannjjm 3018 15 the the DT cord-023095-4dannjjm 3018 16 parameters parameter NNS cord-023095-4dannjjm 3018 17 measured measure VBN cord-023095-4dannjjm 3018 18 in in IN cord-023095-4dannjjm 3018 19 this this DT cord-023095-4dannjjm 3018 20 study study NN cord-023095-4dannjjm 3018 21 . . . cord-023095-4dannjjm 3018 22 ' ' '' cord-023095-4dannjjm 3019 1 Aspirin aspirin NN cord-023095-4dannjjm 3019 2 resistance resistance NN cord-023095-4dannjjm 3019 3 ' ' '' cord-023095-4dannjjm 3019 4 has have VBZ cord-023095-4dannjjm 3019 5 been be VBN cord-023095-4dannjjm 3019 6 identified identify VBN cord-023095-4dannjjm 3019 7 in in IN cord-023095-4dannjjm 3019 8 people people NNS cord-023095-4dannjjm 3019 9 and and CC cord-023095-4dannjjm 3019 10 dogs dog NNS cord-023095-4dannjjm 3019 11 that that WDT cord-023095-4dannjjm 3019 12 develop develop VBP cord-023095-4dannjjm 3019 13 thrombi thrombi NNP cord-023095-4dannjjm 3019 14 despite despite IN cord-023095-4dannjjm 3019 15 low low JJ cord-023095-4dannjjm 3019 16 dose dose NN cord-023095-4dannjjm 3019 17 aspirin aspirin NN cord-023095-4dannjjm 3019 18 therapy therapy NN cord-023095-4dannjjm 3019 19 . . . cord-023095-4dannjjm 3020 1 Variability variability NN cord-023095-4dannjjm 3020 2 in in IN cord-023095-4dannjjm 3020 3 platelet platelet NN cord-023095-4dannjjm 3020 4 cyclooxygenase cyclooxygenase NN cord-023095-4dannjjm 3020 5 ( ( -LRB- cord-023095-4dannjjm 3020 6 COX COX NNP cord-023095-4dannjjm 3020 7 ) ) -RRB- cord-023095-4dannjjm 3020 8 isoform isoform NN cord-023095-4dannjjm 3020 9 expression expression NN cord-023095-4dannjjm 3020 10 is be VBZ cord-023095-4dannjjm 3020 11 one one CD cord-023095-4dannjjm 3020 12 proposed propose VBN cord-023095-4dannjjm 3020 13 mechanism mechanism NN cord-023095-4dannjjm 3020 14 for for IN cord-023095-4dannjjm 3020 15 aspirin aspirin NN cord-023095-4dannjjm 3020 16 resistance resistance NN cord-023095-4dannjjm 3020 17 in in IN cord-023095-4dannjjm 3020 18 people people NNS cord-023095-4dannjjm 3020 19 . . . cord-023095-4dannjjm 3021 1 Two two CD cord-023095-4dannjjm 3021 2 isoforms isoform NNS cord-023095-4dannjjm 3021 3 ( ( -LRB- cord-023095-4dannjjm 3021 4 COX-1 cox-1 JJ cord-023095-4dannjjm 3021 5 and and CC cord-023095-4dannjjm 3021 6 COX-2 COX-2 NNP cord-023095-4dannjjm 3021 7 ) ) -RRB- cord-023095-4dannjjm 3021 8 have have VBP cord-023095-4dannjjm 3021 9 been be VBN cord-023095-4dannjjm 3021 10 identified identify VBN cord-023095-4dannjjm 3021 11 in in IN cord-023095-4dannjjm 3021 12 canine canine JJ cord-023095-4dannjjm 3021 13 platelets platelet NNS cord-023095-4dannjjm 3021 14 . . . cord-023095-4dannjjm 3022 1 High high JJ cord-023095-4dannjjm 3022 2 ( ( -LRB- cord-023095-4dannjjm 3022 3 antiinflammatory antiinflammatory JJ cord-023095-4dannjjm 3022 4 ) ) -RRB- cord-023095-4dannjjm 3022 5 dose dose NN cord-023095-4dannjjm 3022 6 aspirin aspirin NN cord-023095-4dannjjm 3022 7 inhibits inhibit VBZ cord-023095-4dannjjm 3022 8 platelet platelet NN cord-023095-4dannjjm 3022 9 function function NN cord-023095-4dannjjm 3022 10 and and CC cord-023095-4dannjjm 3022 11 alters alter VBZ cord-023095-4dannjjm 3022 12 expression expression NN cord-023095-4dannjjm 3022 13 of of IN cord-023095-4dannjjm 3022 14 both both CC cord-023095-4dannjjm 3022 15 COX COX NNP cord-023095-4dannjjm 3022 16 isoforms isoform NNS cord-023095-4dannjjm 3022 17 in in IN cord-023095-4dannjjm 3022 18 most most JJS cord-023095-4dannjjm 3022 19 dogs dog NNS cord-023095-4dannjjm 3022 20 . . . cord-023095-4dannjjm 3023 1 This this DT cord-023095-4dannjjm 3023 2 study study NN cord-023095-4dannjjm 3023 3 evaluated evaluate VBD cord-023095-4dannjjm 3023 4 the the DT cord-023095-4dannjjm 3023 5 effects effect NNS cord-023095-4dannjjm 3023 6 of of IN cord-023095-4dannjjm 3023 7 low low JJ cord-023095-4dannjjm 3023 8 dose dose NN cord-023095-4dannjjm 3023 9 aspirin aspirin NN cord-023095-4dannjjm 3023 10 on on IN cord-023095-4dannjjm 3023 11 platelet platelet NN cord-023095-4dannjjm 3023 12 function function NN cord-023095-4dannjjm 3023 13 and and CC cord-023095-4dannjjm 3023 14 COX COX NNP cord-023095-4dannjjm 3023 15 expression expression NN cord-023095-4dannjjm 3023 16 in in IN cord-023095-4dannjjm 3023 17 normal normal JJ cord-023095-4dannjjm 3023 18 dogs dog NNS cord-023095-4dannjjm 3023 19 . . . cord-023095-4dannjjm 3024 1 Twenty twenty CD cord-023095-4dannjjm 3024 2 - - HYPH cord-023095-4dannjjm 3024 3 five five CD cord-023095-4dannjjm 3024 4 healthy healthy JJ cord-023095-4dannjjm 3024 5 client client NN cord-023095-4dannjjm 3024 6 - - HYPH cord-023095-4dannjjm 3024 7 owned own VBN cord-023095-4dannjjm 3024 8 dogs dog NNS cord-023095-4dannjjm 3024 9 were be VBD cord-023095-4dannjjm 3024 10 evaluated evaluate VBN cord-023095-4dannjjm 3024 11 before before IN cord-023095-4dannjjm 3024 12 and and CC cord-023095-4dannjjm 3024 13 at at IN cord-023095-4dannjjm 3024 14 two two CD cord-023095-4dannjjm 3024 15 time time NN cord-023095-4dannjjm 3024 16 points point NNS cord-023095-4dannjjm 3024 17 ( ( -LRB- cord-023095-4dannjjm 3024 18 Days day NNS cord-023095-4dannjjm 3024 19 3 3 CD cord-023095-4dannjjm 3024 20 and and CC cord-023095-4dannjjm 3024 21 10 10 CD cord-023095-4dannjjm 3024 22 ) ) -RRB- cord-023095-4dannjjm 3024 23 during during IN cord-023095-4dannjjm 3024 24 aspirin aspirin NN cord-023095-4dannjjm 3024 25 therapy therapy NN cord-023095-4dannjjm 3024 26 ( ( -LRB- cord-023095-4dannjjm 3024 27 1 1 CD cord-023095-4dannjjm 3024 28 mg mg NNP cord-023095-4dannjjm 3024 29 / / SYM cord-023095-4dannjjm 3024 30 kg kg NNP cord-023095-4dannjjm 3024 31 PO PO NNP cord-023095-4dannjjm 3024 32 SID SID NNP cord-023095-4dannjjm 3024 33 ) ) -RRB- cord-023095-4dannjjm 3024 34 . . . cord-023095-4dannjjm 3025 1 Platelet platelet NN cord-023095-4dannjjm 3025 2 response response NN cord-023095-4dannjjm 3025 3 to to IN cord-023095-4dannjjm 3025 4 aspirin aspirin NN cord-023095-4dannjjm 3026 1 ( ( -LRB- cord-023095-4dannjjm 3026 2 Siemens Siemens NNP cord-023095-4dannjjm 3026 3 PFA-100 PFA-100 NNP cord-023095-4dannjjm 3026 4 s s XX cord-023095-4dannjjm 3026 5 ; ; : cord-023095-4dannjjm 3026 6 collagen/ collagen/ CD cord-023095-4dannjjm 3026 7 epinephrine epinephrine NN cord-023095-4dannjjm 3026 8 cartridges cartridge NNS cord-023095-4dannjjm 3026 9 ) ) -RRB- cord-023095-4dannjjm 3026 10 , , , cord-023095-4dannjjm 3026 11 was be VBD cord-023095-4dannjjm 3026 12 stratified stratify VBN cord-023095-4dannjjm 3026 13 into into IN cord-023095-4dannjjm 3026 14 one one CD cord-023095-4dannjjm 3026 15 of of IN cord-023095-4dannjjm 3026 16 three three CD cord-023095-4dannjjm 3026 17 groups group NNS cord-023095-4dannjjm 3026 18 [ [ -LRB- cord-023095-4dannjjm 3026 19 aspirin aspirin NN cord-023095-4dannjjm 3026 20 responders responder NNS cord-023095-4dannjjm 3026 21 ( ( -LRB- cord-023095-4dannjjm 3026 22 9 9 CD cord-023095-4dannjjm 3026 23 dogs dog NNS cord-023095-4dannjjm 3026 24 ) ) -RRB- cord-023095-4dannjjm 3026 25 , , , cord-023095-4dannjjm 3026 26 non non NNS cord-023095-4dannjjm 3026 27 - - NNS cord-023095-4dannjjm 3026 28 responders responder NNS cord-023095-4dannjjm 3026 29 ( ( -LRB- cord-023095-4dannjjm 3026 30 8 8 CD cord-023095-4dannjjm 3026 31 dogs dog NNS cord-023095-4dannjjm 3026 32 ) ) -RRB- cord-023095-4dannjjm 3026 33 , , , cord-023095-4dannjjm 3026 34 or or CC cord-023095-4dannjjm 3026 35 inconsistent inconsistent JJ cord-023095-4dannjjm 3026 36 responders responder NNS cord-023095-4dannjjm 3026 37 ( ( -LRB- cord-023095-4dannjjm 3026 38 8 8 CD cord-023095-4dannjjm 3026 39 dogs dog NNS cord-023095-4dannjjm 3026 40 ) ) -RRB- cord-023095-4dannjjm 3026 41 ] ] -RRB- cord-023095-4dannjjm 3026 42 . . . cord-023095-4dannjjm 3027 1 Flow flow NN cord-023095-4dannjjm 3027 2 cytometry cytometry NN cord-023095-4dannjjm 3027 3 identified identify VBD cord-023095-4dannjjm 3027 4 platelet platelet NN cord-023095-4dannjjm 3027 5 COX-1 cox-1 JJ cord-023095-4dannjjm 3027 6 and and CC cord-023095-4dannjjm 3027 7 COX-2 cox-2 JJ cord-023095-4dannjjm 3027 8 expression expression NN cord-023095-4dannjjm 3027 9 . . . cord-023095-4dannjjm 3028 1 An an DT cord-023095-4dannjjm 3028 2 ELISA ELISA NNP cord-023095-4dannjjm 3028 3 was be VBD cord-023095-4dannjjm 3028 4 used use VBN cord-023095-4dannjjm 3028 5 to to TO cord-023095-4dannjjm 3028 6 measure measure VB cord-023095-4dannjjm 3028 7 urine urine NN cord-023095-4dannjjm 3028 8 11-dehydro 11-dehydro CD cord-023095-4dannjjm 3028 9 - - HYPH cord-023095-4dannjjm 3028 10 thromboxane thromboxane NN cord-023095-4dannjjm 3028 11 B b NN cord-023095-4dannjjm 3028 12 2 2 CD cord-023095-4dannjjm 3028 13 ( ( -LRB- cord-023095-4dannjjm 3028 14 11-dTXB 11-dtxb CD cord-023095-4dannjjm 3028 15 2 2 CD cord-023095-4dannjjm 3028 16 ) ) -RRB- cord-023095-4dannjjm 3028 17 . . . cord-023095-4dannjjm 3029 1 There there EX cord-023095-4dannjjm 3029 2 were be VBD cord-023095-4dannjjm 3029 3 no no DT cord-023095-4dannjjm 3029 4 significant significant JJ cord-023095-4dannjjm 3029 5 differences difference NNS cord-023095-4dannjjm 3029 6 between between IN cord-023095-4dannjjm 3029 7 groups group NNS cord-023095-4dannjjm 3029 8 for for IN cord-023095-4dannjjm 3029 9 COX-1 COX-1 NNP cord-023095-4dannjjm 3029 10 , , , cord-023095-4dannjjm 3029 11 COX-2 COX-2 NNP cord-023095-4dannjjm 3029 12 or or CC cord-023095-4dannjjm 3029 13 11-dTXB 11-dtxb CD cord-023095-4dannjjm 3029 14 2 2 CD cord-023095-4dannjjm 3029 15 at at IN cord-023095-4dannjjm 3029 16 any any DT cord-023095-4dannjjm 3029 17 time time NN cord-023095-4dannjjm 3029 18 point point NN cord-023095-4dannjjm 3029 19 . . . cord-023095-4dannjjm 3030 1 When when WRB cord-023095-4dannjjm 3030 2 all all DT cord-023095-4dannjjm 3030 3 dogs dog NNS cord-023095-4dannjjm 3030 4 were be VBD cord-023095-4dannjjm 3030 5 considered consider VBN cord-023095-4dannjjm 3030 6 as as IN cord-023095-4dannjjm 3030 7 a a DT cord-023095-4dannjjm 3030 8 single single JJ cord-023095-4dannjjm 3030 9 group group NN cord-023095-4dannjjm 3030 10 , , , cord-023095-4dannjjm 3030 11 there there EX cord-023095-4dannjjm 3030 12 was be VBD cord-023095-4dannjjm 3030 13 a a DT cord-023095-4dannjjm 3030 14 significant significant JJ cord-023095-4dannjjm 3030 15 increase increase NN cord-023095-4dannjjm 3030 16 ( ( -LRB- cord-023095-4dannjjm 3030 17 p p NN cord-023095-4dannjjm 3030 18 o o NN cord-023095-4dannjjm 3030 19 0.0001Ã 0.0001ã CD cord-023095-4dannjjm 3030 20 ) ) -RRB- cord-023095-4dannjjm 3030 21 in in IN cord-023095-4dannjjm 3030 22 COX-1 COX-1 NNP cord-023095-4dannjjm 3030 23 and and CC cord-023095-4dannjjm 3030 24 COX-2 COX-2 NNP cord-023095-4dannjjm 3030 25 mean mean VB cord-023095-4dannjjm 3030 26 fluorescent fluorescent JJ cord-023095-4dannjjm 3030 27 intensity intensity NN cord-023095-4dannjjm 3030 28 ( ( -LRB- cord-023095-4dannjjm 3030 29 MFI MFI NNP cord-023095-4dannjjm 3030 30 ) ) -RRB- cord-023095-4dannjjm 3030 31 from from IN cord-023095-4dannjjm 3030 32 baseline baseline NN cord-023095-4dannjjm 3030 33 to to IN cord-023095-4dannjjm 3030 34 Day Day NNP cord-023095-4dannjjm 3030 35 10 10 CD cord-023095-4dannjjm 3030 36 , , , cord-023095-4dannjjm 3030 37 70.1 70.1 CD cord-023095-4dannjjm 3030 38 % % NN cord-023095-4dannjjm 3030 39 AE AE NNP cord-023095-4dannjjm 3030 40 38.0 38.0 CD cord-023095-4dannjjm 3030 41 ( ( -LRB- cord-023095-4dannjjm 3030 42 mean mean UH cord-023095-4dannjjm 3030 43 AE AE NNP cord-023095-4dannjjm 3030 44 SD SD NNP cord-023095-4dannjjm 3030 45 ) ) -RRB- cord-023095-4dannjjm 3030 46 and and CC cord-023095-4dannjjm 3030 47 70.8 70.8 CD cord-023095-4dannjjm 3030 48 % % NN cord-023095-4dannjjm 3030 49 AE AE NNP cord-023095-4dannjjm 3030 50 71.2 71.2 CD cord-023095-4dannjjm 3030 51 , , , cord-023095-4dannjjm 3030 52 respectively respectively RB cord-023095-4dannjjm 3030 53 . . . cord-023095-4dannjjm 3031 1 There there EX cord-023095-4dannjjm 3031 2 was be VBD cord-023095-4dannjjm 3031 3 a a DT cord-023095-4dannjjm 3031 4 significant significant JJ cord-023095-4dannjjm 3031 5 decrease decrease NN cord-023095-4dannjjm 3031 6 in in IN cord-023095-4dannjjm 3031 7 mean mean JJ cord-023095-4dannjjm 3031 8 urine urine NN cord-023095-4dannjjm 3031 9 11-dTXB 11-dtxb CD cord-023095-4dannjjm 3031 10 2 2 CD cord-023095-4dannjjm 3032 1 : : : cord-023095-4dannjjm 3032 2 creatinine creatinine NN cord-023095-4dannjjm 3032 3 on on IN cord-023095-4dannjjm 3032 4 Day Day NNP cord-023095-4dannjjm 3032 5 3 3 CD cord-023095-4dannjjm 3032 6 and and CC cord-023095-4dannjjm 3032 7 10 10 CD cord-023095-4dannjjm 3032 8 by by IN cord-023095-4dannjjm 3032 9 23.4 23.4 CD cord-023095-4dannjjm 3032 10 % % NN cord-023095-4dannjjm 3032 11 ( ( -LRB- cord-023095-4dannjjm 3032 12 p p NN cord-023095-4dannjjm 3032 13 5 5 CD cord-023095-4dannjjm 3032 14 0.0044 0.0044 CD cord-023095-4dannjjm 3032 15 Ã Ã NNP cord-023095-4dannjjm 3032 16 ) ) -RRB- cord-023095-4dannjjm 3032 17 and and CC cord-023095-4dannjjm 3032 18 45 45 CD cord-023095-4dannjjm 3032 19 % % NN cord-023095-4dannjjm 3032 20 ( ( -LRB- cord-023095-4dannjjm 3032 21 p p NN cord-023095-4dannjjm 3032 22 o o NN cord-023095-4dannjjm 3032 23 0.0001 0.0001 CD cord-023095-4dannjjm 3032 24 Ã Ã NNP cord-023095-4dannjjm 3032 25 ) ) -RRB- cord-023095-4dannjjm 3032 26 . . . cord-023095-4dannjjm 3033 1 As as IN cord-023095-4dannjjm 3033 2 with with IN cord-023095-4dannjjm 3033 3 our -PRON- PRP$ cord-023095-4dannjjm 3033 4 previous previous JJ cord-023095-4dannjjm 3033 5 high high JJ cord-023095-4dannjjm 3033 6 dose dose NN cord-023095-4dannjjm 3033 7 studies study NNS cord-023095-4dannjjm 3033 8 , , , cord-023095-4dannjjm 3033 9 COX-1 cox-1 JJ cord-023095-4dannjjm 3033 10 expression expression NN cord-023095-4dannjjm 3033 11 was be VBD cord-023095-4dannjjm 3033 12 increased increase VBN cord-023095-4dannjjm 3033 13 with with IN cord-023095-4dannjjm 3033 14 aspirin aspirin NN cord-023095-4dannjjm 3033 15 exposure exposure NN cord-023095-4dannjjm 3033 16 . . . cord-023095-4dannjjm 3034 1 However however RB cord-023095-4dannjjm 3034 2 , , , cord-023095-4dannjjm 3034 3 there there EX cord-023095-4dannjjm 3034 4 was be VBD cord-023095-4dannjjm 3034 5 a a DT cord-023095-4dannjjm 3034 6 significant significant JJ cord-023095-4dannjjm 3034 7 increase increase NN cord-023095-4dannjjm 3034 8 in in IN cord-023095-4dannjjm 3034 9 COX-2 cox-2 JJ cord-023095-4dannjjm 3034 10 expression expression NN cord-023095-4dannjjm 3034 11 with with IN cord-023095-4dannjjm 3034 12 low low JJ cord-023095-4dannjjm 3034 13 dose dose NN cord-023095-4dannjjm 3034 14 aspirin aspirin NN cord-023095-4dannjjm 3034 15 in in IN cord-023095-4dannjjm 3034 16 contrast contrast NN cord-023095-4dannjjm 3034 17 to to IN cord-023095-4dannjjm 3034 18 the the DT cord-023095-4dannjjm 3034 19 decrease decrease NN cord-023095-4dannjjm 3034 20 seen see VBN cord-023095-4dannjjm 3034 21 at at IN cord-023095-4dannjjm 3034 22 higher high JJR cord-023095-4dannjjm 3034 23 doses dose NNS cord-023095-4dannjjm 3034 24 . . . cord-023095-4dannjjm 3035 1 Our -PRON- PRP$ cord-023095-4dannjjm 3035 2 study study NN cord-023095-4dannjjm 3035 3 suggests suggest VBZ cord-023095-4dannjjm 3035 4 that that IN cord-023095-4dannjjm 3035 5 levels level NNS cord-023095-4dannjjm 3035 6 of of IN cord-023095-4dannjjm 3035 7 platelet platelet NN cord-023095-4dannjjm 3035 8 COX-1 cox-1 JJ cord-023095-4dannjjm 3035 9 and and CC cord-023095-4dannjjm 3035 10 COX-2 cox-2 JJ cord-023095-4dannjjm 3035 11 expression expression NN cord-023095-4dannjjm 3035 12 do do VBP cord-023095-4dannjjm 3035 13 not not RB cord-023095-4dannjjm 3035 14 influence influence VB cord-023095-4dannjjm 3035 15 aspirin aspirin NN cord-023095-4dannjjm 3035 16 response response NN cord-023095-4dannjjm 3035 17 in in IN cord-023095-4dannjjm 3035 18 dogs dog NNS cord-023095-4dannjjm 3035 19 . . . cord-023095-4dannjjm 3036 1 Although although IN cord-023095-4dannjjm 3036 2 thromboxane thromboxane NN cord-023095-4dannjjm 3036 3 levels level NNS cord-023095-4dannjjm 3036 4 decreased decrease VBD cord-023095-4dannjjm 3036 5 in in IN cord-023095-4dannjjm 3036 6 most most RBS cord-023095-4dannjjm 3036 7 ( ( -LRB- cord-023095-4dannjjm 3036 8 23 23 CD cord-023095-4dannjjm 3036 9 of of IN cord-023095-4dannjjm 3036 10 25 25 CD cord-023095-4dannjjm 3036 11 ) ) -RRB- cord-023095-4dannjjm 3036 12 dogs dog NNS cord-023095-4dannjjm 3036 13 on on IN cord-023095-4dannjjm 3036 14 low low JJ cord-023095-4dannjjm 3036 15 dose dose NN cord-023095-4dannjjm 3036 16 aspirin aspirin NN cord-023095-4dannjjm 3036 17 , , , cord-023095-4dannjjm 3036 18 platelet platelet NN cord-023095-4dannjjm 3036 19 function function NN cord-023095-4dannjjm 3036 20 was be VBD cord-023095-4dannjjm 3036 21 consistently consistently RB cord-023095-4dannjjm 3036 22 affected affect VBN cord-023095-4dannjjm 3036 23 in in IN cord-023095-4dannjjm 3036 24 only only RB cord-023095-4dannjjm 3036 25 36 36 CD cord-023095-4dannjjm 3036 26 % % NN cord-023095-4dannjjm 3036 27 of of IN cord-023095-4dannjjm 3036 28 dogs dog NNS cord-023095-4dannjjm 3036 29 , , , cord-023095-4dannjjm 3036 30 suggesting suggest VBG cord-023095-4dannjjm 3036 31 that that IN cord-023095-4dannjjm 3036 32 differences difference NNS cord-023095-4dannjjm 3036 33 in in IN cord-023095-4dannjjm 3036 34 response response NN cord-023095-4dannjjm 3036 35 to to IN cord-023095-4dannjjm 3036 36 thromboxane thromboxane NN cord-023095-4dannjjm 3036 37 may may MD cord-023095-4dannjjm 3036 38 play play VB cord-023095-4dannjjm 3036 39 a a DT cord-023095-4dannjjm 3036 40 role role NN cord-023095-4dannjjm 3036 41 in in IN cord-023095-4dannjjm 3036 42 the the DT cord-023095-4dannjjm 3036 43 variable variable JJ cord-023095-4dannjjm 3036 44 affects affect NNS cord-023095-4dannjjm 3036 45 of of IN cord-023095-4dannjjm 3036 46 low low JJ cord-023095-4dannjjm 3036 47 dose dose NN cord-023095-4dannjjm 3036 48 aspirin aspirin NN cord-023095-4dannjjm 3036 49 on on IN cord-023095-4dannjjm 3036 50 canine canine JJ cord-023095-4dannjjm 3036 51 platelet platelet NN cord-023095-4dannjjm 3036 52 function function NN cord-023095-4dannjjm 3036 53 . . . cord-023095-4dannjjm 3037 1 Delayed delayed JJ cord-023095-4dannjjm 3037 2 postoperative postoperative JJ cord-023095-4dannjjm 3037 3 bleeding bleeding NN cord-023095-4dannjjm 3037 4 is be VBZ cord-023095-4dannjjm 3037 5 common common JJ cord-023095-4dannjjm 3037 6 in in IN cord-023095-4dannjjm 3037 7 retired retired JJ cord-023095-4dannjjm 3037 8 racing racing NN cord-023095-4dannjjm 3037 9 Greyhounds greyhound NNS cord-023095-4dannjjm 3037 10 ( ( -LRB- cord-023095-4dannjjm 3037 11 RRGs RRGs NNP cord-023095-4dannjjm 3037 12 ) ) -RRB- cord-023095-4dannjjm 3037 13 , , , cord-023095-4dannjjm 3037 14 despite despite IN cord-023095-4dannjjm 3037 15 normal normal JJ cord-023095-4dannjjm 3037 16 results result NNS cord-023095-4dannjjm 3037 17 of of IN cord-023095-4dannjjm 3037 18 routine routine JJ cord-023095-4dannjjm 3037 19 hemostasis hemostasis NN cord-023095-4dannjjm 3037 20 assays assay NNS cord-023095-4dannjjm 3037 21 . . . cord-023095-4dannjjm 3038 1 The the DT cord-023095-4dannjjm 3038 2 excessive excessive JJ cord-023095-4dannjjm 3038 3 postoperative postoperative JJ cord-023095-4dannjjm 3038 4 bleeding bleeding NN cord-023095-4dannjjm 3038 5 in in IN cord-023095-4dannjjm 3038 6 the the DT cord-023095-4dannjjm 3038 7 RRGs rrg NNS cord-023095-4dannjjm 3038 8 is be VBZ cord-023095-4dannjjm 3038 9 not not RB cord-023095-4dannjjm 3038 10 due due JJ cord-023095-4dannjjm 3038 11 to to IN cord-023095-4dannjjm 3038 12 primary primary JJ cord-023095-4dannjjm 3038 13 or or CC cord-023095-4dannjjm 3038 14 secondary secondary JJ cord-023095-4dannjjm 3038 15 hemostatic hemostatic JJ cord-023095-4dannjjm 3038 16 defects defect NNS cord-023095-4dannjjm 3038 17 , , , cord-023095-4dannjjm 3038 18 and and CC cord-023095-4dannjjm 3038 19 may may MD cord-023095-4dannjjm 3038 20 be be VB cord-023095-4dannjjm 3038 21 due due JJ cord-023095-4dannjjm 3038 22 to to IN cord-023095-4dannjjm 3038 23 enhanced enhance VBN cord-023095-4dannjjm 3038 24 fibrinolysis fibrinolysis NN cord-023095-4dannjjm 3038 25 or or CC cord-023095-4dannjjm 3038 26 to to IN cord-023095-4dannjjm 3038 27 a a DT cord-023095-4dannjjm 3038 28 clot clot NN cord-023095-4dannjjm 3038 29 maintenance maintenance NN cord-023095-4dannjjm 3038 30 dysfunction dysfunction NN cord-023095-4dannjjm 3038 31 . . . cord-023095-4dannjjm 3039 1 Providing provide VBG cord-023095-4dannjjm 3039 2 a a DT cord-023095-4dannjjm 3039 3 method method NN cord-023095-4dannjjm 3039 4 to to TO cord-023095-4dannjjm 3039 5 prevent prevent VB cord-023095-4dannjjm 3039 6 or or CC cord-023095-4dannjjm 3039 7 minimize minimize VB cord-023095-4dannjjm 3039 8 the the DT cord-023095-4dannjjm 3039 9 severity severity NN cord-023095-4dannjjm 3039 10 of of IN cord-023095-4dannjjm 3039 11 postoperative postoperative JJ cord-023095-4dannjjm 3039 12 bleeding bleeding NN cord-023095-4dannjjm 3039 13 in in IN cord-023095-4dannjjm 3039 14 RRGs rrg NNS cord-023095-4dannjjm 3039 15 will will MD cord-023095-4dannjjm 3039 16 not not RB cord-023095-4dannjjm 3039 17 only only RB cord-023095-4dannjjm 3039 18 have have VB cord-023095-4dannjjm 3039 19 major major JJ cord-023095-4dannjjm 3039 20 economic economic JJ cord-023095-4dannjjm 3039 21 impact impact NN cord-023095-4dannjjm 3039 22 for for IN cord-023095-4dannjjm 3039 23 owners owner NNS cord-023095-4dannjjm 3039 24 , , , cord-023095-4dannjjm 3039 25 but but CC cord-023095-4dannjjm 3039 26 also also RB cord-023095-4dannjjm 3039 27 will will MD cord-023095-4dannjjm 3039 28 markedly markedly RB cord-023095-4dannjjm 3039 29 decrease decrease VB cord-023095-4dannjjm 3039 30 the the DT cord-023095-4dannjjm 3039 31 associated associate VBN cord-023095-4dannjjm 3039 32 complications complication NNS cord-023095-4dannjjm 3039 33 of of IN cord-023095-4dannjjm 3039 34 minor minor JJ cord-023095-4dannjjm 3039 35 or or CC cord-023095-4dannjjm 3039 36 major major JJ cord-023095-4dannjjm 3039 37 surgeries surgery NNS cord-023095-4dannjjm 3039 38 in in IN cord-023095-4dannjjm 3039 39 the the DT cord-023095-4dannjjm 3039 40 breed breed NN cord-023095-4dannjjm 3039 41 . . . cord-023095-4dannjjm 3040 1 Epsilon Epsilon NNP cord-023095-4dannjjm 3040 2 aminocaproic aminocaproic NNP cord-023095-4dannjjm 3040 3 acid acid NN cord-023095-4dannjjm 3040 4 ( ( -LRB- cord-023095-4dannjjm 3040 5 EACA EACA NNP cord-023095-4dannjjm 3040 6 ) ) -RRB- cord-023095-4dannjjm 3040 7 is be VBZ cord-023095-4dannjjm 3040 8 a a DT cord-023095-4dannjjm 3040 9 potent potent JJ cord-023095-4dannjjm 3040 10 inhibitor inhibitor NN cord-023095-4dannjjm 3040 11 of of IN cord-023095-4dannjjm 3040 12 fibrinolysis fibrinolysis NN cord-023095-4dannjjm 3040 13 that that WDT cord-023095-4dannjjm 3040 14 also also RB cord-023095-4dannjjm 3040 15 supports support VBZ cord-023095-4dannjjm 3040 16 clot clot NN cord-023095-4dannjjm 3040 17 maintenance maintenance NN cord-023095-4dannjjm 3040 18 due due JJ cord-023095-4dannjjm 3040 19 to to IN cord-023095-4dannjjm 3040 20 unknown unknown JJ cord-023095-4dannjjm 3040 21 mechanisms mechanism NNS cord-023095-4dannjjm 3040 22 . . . cord-023095-4dannjjm 3041 1 The the DT cord-023095-4dannjjm 3041 2 objective objective NN cord-023095-4dannjjm 3041 3 of of IN cord-023095-4dannjjm 3041 4 this this DT cord-023095-4dannjjm 3041 5 double double JJ cord-023095-4dannjjm 3041 6 - - HYPH cord-023095-4dannjjm 3041 7 blinded blinded JJ cord-023095-4dannjjm 3041 8 , , , cord-023095-4dannjjm 3041 9 prospective prospective JJ cord-023095-4dannjjm 3041 10 , , , cord-023095-4dannjjm 3041 11 randomized randomized JJ cord-023095-4dannjjm 3041 12 study study NN cord-023095-4dannjjm 3041 13 was be VBD cord-023095-4dannjjm 3041 14 to to TO cord-023095-4dannjjm 3041 15 evaluate evaluate VB cord-023095-4dannjjm 3041 16 the the DT cord-023095-4dannjjm 3041 17 effects effect NNS cord-023095-4dannjjm 3041 18 of of IN cord-023095-4dannjjm 3041 19 EACA EACA NNS cord-023095-4dannjjm 3041 20 versus versus IN cord-023095-4dannjjm 3041 21 placebo placebo NN cord-023095-4dannjjm 3041 22 on on IN cord-023095-4dannjjm 3041 23 the the DT cord-023095-4dannjjm 3041 24 prevalence prevalence NN cord-023095-4dannjjm 3041 25 of of IN cord-023095-4dannjjm 3041 26 bleeding bleed VBG cord-023095-4dannjjm 3041 27 in in IN cord-023095-4dannjjm 3041 28 RRGs rrg NNS cord-023095-4dannjjm 3041 29 , , , cord-023095-4dannjjm 3041 30 and and CC cord-023095-4dannjjm 3041 31 to to TO cord-023095-4dannjjm 3041 32 investigate investigate VB cord-023095-4dannjjm 3041 33 its -PRON- PRP$ cord-023095-4dannjjm 3041 34 mechanism mechanism NN cord-023095-4dannjjm 3041 35 of of IN cord-023095-4dannjjm 3041 36 action action NN cord-023095-4dannjjm 3041 37 by by IN cord-023095-4dannjjm 3041 38 using use VBG cord-023095-4dannjjm 3041 39 thromboelastography thromboelastography NNP cord-023095-4dannjjm 3041 40 ( ( -LRB- cord-023095-4dannjjm 3041 41 TEG TEG NNP cord-023095-4dannjjm 3041 42 ) ) -RRB- cord-023095-4dannjjm 3041 43 . . . cord-023095-4dannjjm 3042 1 We -PRON- PRP cord-023095-4dannjjm 3042 2 compared compare VBD cord-023095-4dannjjm 3042 3 the the DT cord-023095-4dannjjm 3042 4 effects effect NNS cord-023095-4dannjjm 3042 5 of of IN cord-023095-4dannjjm 3042 6 EACA EACA NNS cord-023095-4dannjjm 3042 7 and and CC cord-023095-4dannjjm 3042 8 placebo placebo NN cord-023095-4dannjjm 3042 9 in in IN cord-023095-4dannjjm 3042 10 100 100 CD cord-023095-4dannjjm 3042 11 RRGs rrg NNS cord-023095-4dannjjm 3042 12 that that WDT cord-023095-4dannjjm 3042 13 underwent undergo VBD cord-023095-4dannjjm 3042 14 elective elective JJ cord-023095-4dannjjm 3042 15 ovariohysterectomy ovariohysterectomy NN cord-023095-4dannjjm 3042 16 or or CC cord-023095-4dannjjm 3042 17 orchiectomy orchiectomy NN cord-023095-4dannjjm 3042 18 at at IN cord-023095-4dannjjm 3042 19 the the DT cord-023095-4dannjjm 3042 20 Veterinary Veterinary NNP cord-023095-4dannjjm 3042 21 Medical Medical NNP cord-023095-4dannjjm 3042 22 Center Center NNP cord-023095-4dannjjm 3042 23 , , , cord-023095-4dannjjm 3042 24 The the DT cord-023095-4dannjjm 3042 25 Ohio Ohio NNP cord-023095-4dannjjm 3042 26 State State NNP cord-023095-4dannjjm 3042 27 University University NNP cord-023095-4dannjjm 3042 28 during during IN cord-023095-4dannjjm 3042 29 2 2 CD cord-023095-4dannjjm 3042 30 years year NNS cord-023095-4dannjjm 3042 31 . . . cord-023095-4dannjjm 3043 1 The the DT cord-023095-4dannjjm 3043 2 main main JJ cord-023095-4dannjjm 3043 3 endpoint endpoint NN cord-023095-4dannjjm 3043 4 was be VBD cord-023095-4dannjjm 3043 5 bleeding bleed VBG cord-023095-4dannjjm 3043 6 ( ( -LRB- cord-023095-4dannjjm 3043 7 prevalence prevalence NN cord-023095-4dannjjm 3043 8 and and CC cord-023095-4dannjjm 3043 9 severity severity NN cord-023095-4dannjjm 3043 10 ) ) -RRB- cord-023095-4dannjjm 3043 11 ; ; , cord-023095-4dannjjm 3043 12 minor minor JJ cord-023095-4dannjjm 3043 13 endpoints endpoint NNS cord-023095-4dannjjm 3043 14 included include VBD cord-023095-4dannjjm 3043 15 most most JJS cord-023095-4dannjjm 3043 16 TEG TEG NNP cord-023095-4dannjjm 3043 17 parameters parameter NNS cord-023095-4dannjjm 3043 18 . . . cord-023095-4dannjjm 3044 1 Thirty thirty CD cord-023095-4dannjjm 3044 2 percent percent NN cord-023095-4dannjjm 3044 3 ( ( -LRB- cord-023095-4dannjjm 3044 4 15/50 15/50 CD cord-023095-4dannjjm 3044 5 ) ) -RRB- cord-023095-4dannjjm 3044 6 of of IN cord-023095-4dannjjm 3044 7 the the DT cord-023095-4dannjjm 3044 8 RRGs rrg NNS cord-023095-4dannjjm 3044 9 in in IN cord-023095-4dannjjm 3044 10 the the DT cord-023095-4dannjjm 3044 11 placebo placebo NN cord-023095-4dannjjm 3044 12 group group NN cord-023095-4dannjjm 3044 13 had have VBD cord-023095-4dannjjm 3044 14 delayed delay VBN cord-023095-4dannjjm 3044 15 postoperative postoperative JJ cord-023095-4dannjjm 3044 16 bleeding bleeding NN cord-023095-4dannjjm 3044 17 starting start VBG cord-023095-4dannjjm 3044 18 36 36 CD cord-023095-4dannjjm 3044 19 to to TO cord-023095-4dannjjm 3044 20 48 48 CD cord-023095-4dannjjm 3044 21 hours hour NNS cord-023095-4dannjjm 3044 22 after after IN cord-023095-4dannjjm 3044 23 surgery surgery NN cord-023095-4dannjjm 3044 24 , , , cord-023095-4dannjjm 3044 25 compared compare VBN cord-023095-4dannjjm 3044 26 to to IN cord-023095-4dannjjm 3044 27 10 10 CD cord-023095-4dannjjm 3044 28 % % NN cord-023095-4dannjjm 3044 29 ( ( -LRB- cord-023095-4dannjjm 3044 30 5/50 5/50 CD cord-023095-4dannjjm 3044 31 ) ) -RRB- cord-023095-4dannjjm 3044 32 in in IN cord-023095-4dannjjm 3044 33 the the DT cord-023095-4dannjjm 3044 34 EACA EACA NNP cord-023095-4dannjjm 3044 35 group group NN cord-023095-4dannjjm 3044 36 ( ( -LRB- cord-023095-4dannjjm 3044 37 P p NN cord-023095-4dannjjm 3044 38 5 5 CD cord-023095-4dannjjm 3044 39 0.0124 0.0124 CD cord-023095-4dannjjm 3044 40 ) ) -RRB- cord-023095-4dannjjm 3044 41 . . . cord-023095-4dannjjm 3045 1 On on IN cord-023095-4dannjjm 3045 2 the the DT cord-023095-4dannjjm 3045 3 TEG TEG NNP cord-023095-4dannjjm 3045 4 parameters parameter NNS cord-023095-4dannjjm 3045 5 , , , cord-023095-4dannjjm 3045 6 the the DT cord-023095-4dannjjm 3045 7 R R NNP cord-023095-4dannjjm 3045 8 time time NN cord-023095-4dannjjm 3045 9 ( ( -LRB- cord-023095-4dannjjm 3045 10 clot clot NN cord-023095-4dannjjm 3045 11 formation formation NN cord-023095-4dannjjm 3045 12 time time NN cord-023095-4dannjjm 3045 13 ) ) -RRB- cord-023095-4dannjjm 3045 14 was be VBD cord-023095-4dannjjm 3045 15 significantly significantly RB cord-023095-4dannjjm 3045 16 different different JJ cord-023095-4dannjjm 3045 17 between between IN cord-023095-4dannjjm 3045 18 treatment treatment NN cord-023095-4dannjjm 3045 19 groups group NNS cord-023095-4dannjjm 3045 20 ( ( -LRB- cord-023095-4dannjjm 3045 21 P p NN cord-023095-4dannjjm 3045 22 5 5 CD cord-023095-4dannjjm 3045 23 0.0321 0.0321 CD cord-023095-4dannjjm 3045 24 ) ) -RRB- cord-023095-4dannjjm 3045 25 . . . cord-023095-4dannjjm 3046 1 The the DT cord-023095-4dannjjm 3046 2 postoperative postoperative JJ cord-023095-4dannjjm 3046 3 administration administration NN cord-023095-4dannjjm 3046 4 of of IN cord-023095-4dannjjm 3046 5 EACA EACA NNP cord-023095-4dannjjm 3046 6 significantly significantly RB cord-023095-4dannjjm 3046 7 decreased decrease VBD cord-023095-4dannjjm 3046 8 the the DT cord-023095-4dannjjm 3046 9 prevalence prevalence NN cord-023095-4dannjjm 3046 10 of of IN cord-023095-4dannjjm 3046 11 postoperative postoperative JJ cord-023095-4dannjjm 3046 12 bleeding bleeding NN cord-023095-4dannjjm 3046 13 in in IN cord-023095-4dannjjm 3046 14 RRGs rrg NNS cord-023095-4dannjjm 3046 15 . . . cord-023095-4dannjjm 3047 1 Thromboembolism Thromboembolism NNP cord-023095-4dannjjm 3047 2 associated associate VBN cord-023095-4dannjjm 3047 3 with with IN cord-023095-4dannjjm 3047 4 protein protein NN cord-023095-4dannjjm 3047 5 losing lose VBG cord-023095-4dannjjm 3047 6 nephropathy nephropathy NN cord-023095-4dannjjm 3047 7 ( ( -LRB- cord-023095-4dannjjm 3047 8 PLN PLN NNP cord-023095-4dannjjm 3047 9 ) ) -RRB- cord-023095-4dannjjm 3047 10 has have VBZ cord-023095-4dannjjm 3047 11 been be VBN cord-023095-4dannjjm 3047 12 long long RB cord-023095-4dannjjm 3047 13 recognized recognize VBN cord-023095-4dannjjm 3047 14 as as IN cord-023095-4dannjjm 3047 15 a a DT cord-023095-4dannjjm 3047 16 serious serious JJ cord-023095-4dannjjm 3047 17 and and CC cord-023095-4dannjjm 3047 18 unpredictable unpredictable JJ cord-023095-4dannjjm 3047 19 complication complication NN cord-023095-4dannjjm 3047 20 in in IN cord-023095-4dannjjm 3047 21 dogs dog NNS cord-023095-4dannjjm 3047 22 , , , cord-023095-4dannjjm 3047 23 however however RB cord-023095-4dannjjm 3047 24 its -PRON- PRP$ cord-023095-4dannjjm 3047 25 prevalence prevalence NN cord-023095-4dannjjm 3047 26 remains remain VBZ cord-023095-4dannjjm 3047 27 unknown unknown JJ cord-023095-4dannjjm 3047 28 . . . cord-023095-4dannjjm 3048 1 In in IN cord-023095-4dannjjm 3048 2 humans human NNS cord-023095-4dannjjm 3048 3 , , , cord-023095-4dannjjm 3048 4 surrogate surrogate JJ cord-023095-4dannjjm 3048 5 indicators indicator NNS cord-023095-4dannjjm 3048 6 are be VBP cord-023095-4dannjjm 3048 7 frequently frequently RB cord-023095-4dannjjm 3048 8 used use VBN cord-023095-4dannjjm 3048 9 to to TO cord-023095-4dannjjm 3048 10 assess assess VB cord-023095-4dannjjm 3048 11 thromboembolic thromboembolic JJ cord-023095-4dannjjm 3048 12 risk risk NN cord-023095-4dannjjm 3048 13 . . . cord-023095-4dannjjm 3049 1 This this DT cord-023095-4dannjjm 3049 2 study study NN cord-023095-4dannjjm 3049 3 aimed aim VBD cord-023095-4dannjjm 3049 4 to to TO cord-023095-4dannjjm 3049 5 investigate investigate VB cord-023095-4dannjjm 3049 6 the the DT cord-023095-4dannjjm 3049 7 prevalence prevalence NN cord-023095-4dannjjm 3049 8 of of IN cord-023095-4dannjjm 3049 9 hypercoagulability hypercoagulability NN cord-023095-4dannjjm 3049 10 in in IN cord-023095-4dannjjm 3049 11 PLN PLN NNP cord-023095-4dannjjm 3049 12 dogs dog NNS cord-023095-4dannjjm 3049 13 based base VBN cord-023095-4dannjjm 3049 14 on on IN cord-023095-4dannjjm 3049 15 thromboelastography thromboelastography NNP cord-023095-4dannjjm 3049 16 ( ( -LRB- cord-023095-4dannjjm 3049 17 TEG TEG NNP cord-023095-4dannjjm 3049 18 ) ) -RRB- cord-023095-4dannjjm 3049 19 , , , cord-023095-4dannjjm 3049 20 and and CC cord-023095-4dannjjm 3049 21 to to TO cord-023095-4dannjjm 3049 22 determine determine VB cord-023095-4dannjjm 3049 23 whether whether IN cord-023095-4dannjjm 3049 24 hypercoagulability hypercoagulability NN cord-023095-4dannjjm 3049 25 in in IN cord-023095-4dannjjm 3049 26 these these DT cord-023095-4dannjjm 3049 27 patients patient NNS cord-023095-4dannjjm 3049 28 could could MD cord-023095-4dannjjm 3049 29 be be VB cord-023095-4dannjjm 3049 30 predicted predict VBN cord-023095-4dannjjm 3049 31 by by IN cord-023095-4dannjjm 3049 32 clinical clinical JJ cord-023095-4dannjjm 3049 33 assessments assessment NNS cord-023095-4dannjjm 3049 34 that that WDT cord-023095-4dannjjm 3049 35 identify identify VBP cord-023095-4dannjjm 3049 36 systemic systemic JJ cord-023095-4dannjjm 3049 37 hypertension hypertension NN cord-023095-4dannjjm 3049 38 ( ( -LRB- cord-023095-4dannjjm 3049 39 systolic systolic JJ cord-023095-4dannjjm 3049 40 blood blood NN cord-023095-4dannjjm 3049 41 pressure pressure NN cord-023095-4dannjjm 3049 42 4 4 CD cord-023095-4dannjjm 3049 43 160 160 CD cord-023095-4dannjjm 3049 44 mmHg mmHg NNPS cord-023095-4dannjjm 3049 45 ) ) -RRB- cord-023095-4dannjjm 3049 46 , , , cord-023095-4dannjjm 3049 47 hypoalbuminemia hypoalbuminemia NNP cord-023095-4dannjjm 3049 48 ( ( -LRB- cord-023095-4dannjjm 3049 49 serum serum NN cord-023095-4dannjjm 3049 50 albumin albumin NN cord-023095-4dannjjm 3049 51 o o NNP cord-023095-4dannjjm 3049 52 2.7 2.7 CD cord-023095-4dannjjm 3049 53 mg mg NNP cord-023095-4dannjjm 3049 54 / / SYM cord-023095-4dannjjm 3049 55 dl dl NNP cord-023095-4dannjjm 3049 56 ) ) -RRB- cord-023095-4dannjjm 3049 57 , , , cord-023095-4dannjjm 3049 58 antithrombin antithrombin NN cord-023095-4dannjjm 3049 59 activity activity NN cord-023095-4dannjjm 3049 60 ( ( -LRB- cord-023095-4dannjjm 3049 61 o o UH cord-023095-4dannjjm 3049 62 70 70 CD cord-023095-4dannjjm 3049 63 % % NN cord-023095-4dannjjm 3049 64 ) ) -RRB- cord-023095-4dannjjm 3049 65 , , , cord-023095-4dannjjm 3049 66 and and CC cord-023095-4dannjjm 3049 67 degree degree NN cord-023095-4dannjjm 3049 68 of of IN cord-023095-4dannjjm 3049 69 proteinuria proteinuria NN cord-023095-4dannjjm 3049 70 ( ( -LRB- cord-023095-4dannjjm 3049 71 urine urine NN cord-023095-4dannjjm 3049 72 protein protein NN cord-023095-4dannjjm 3049 73 : : : cord-023095-4dannjjm 3049 74 creatinine creatinine NN cord-023095-4dannjjm 3049 75 ratio ratio NN cord-023095-4dannjjm 3049 76 [ [ -LRB- cord-023095-4dannjjm 3049 77 UPC UPC NNP cord-023095-4dannjjm 3049 78 ] ] -RRB- cord-023095-4dannjjm 3049 79 ! ! . cord-023095-4dannjjm 3049 80 2 2 CD cord-023095-4dannjjm 3049 81 ) ) -RRB- cord-023095-4dannjjm 3049 82 . . . cord-023095-4dannjjm 3050 1 Between between IN cord-023095-4dannjjm 3050 2 March March NNP cord-023095-4dannjjm 3050 3 2009-September 2009-september CD cord-023095-4dannjjm 3050 4 2010 2010 CD cord-023095-4dannjjm 3050 5 , , , cord-023095-4dannjjm 3050 6 twenty twenty CD cord-023095-4dannjjm 3050 7 - - HYPH cord-023095-4dannjjm 3050 8 seven seven CD cord-023095-4dannjjm 3050 9 dogs dog NNS cord-023095-4dannjjm 3050 10 were be VBD cord-023095-4dannjjm 3050 11 identified identify VBN cord-023095-4dannjjm 3050 12 with with IN cord-023095-4dannjjm 3050 13 PLN PLN NNP cord-023095-4dannjjm 3050 14 at at IN cord-023095-4dannjjm 3050 15 the the DT cord-023095-4dannjjm 3050 16 Animal Animal NNP cord-023095-4dannjjm 3050 17 Medical Medical NNP cord-023095-4dannjjm 3050 18 Center Center NNP cord-023095-4dannjjm 3050 19 . . . cord-023095-4dannjjm 3051 1 The the DT cord-023095-4dannjjm 3051 2 prevalence prevalence NN cord-023095-4dannjjm 3051 3 of of IN cord-023095-4dannjjm 3051 4 hypercoagulability hypercoagulability NN cord-023095-4dannjjm 3051 5 based base VBN cord-023095-4dannjjm 3051 6 on on IN cord-023095-4dannjjm 3051 7 a a DT cord-023095-4dannjjm 3051 8 TEG TEG NNP cord-023095-4dannjjm 3051 9 G g NN cord-023095-4dannjjm 3051 10 - - HYPH cord-023095-4dannjjm 3051 11 value value NN cord-023095-4dannjjm 3051 12 4 4 CD cord-023095-4dannjjm 3051 13 9.6 9.6 CD cord-023095-4dannjjm 3051 14 was be VBD cord-023095-4dannjjm 3051 15 83.3 83.3 CD cord-023095-4dannjjm 3051 16 % % NN cord-023095-4dannjjm 3051 17 . . . cord-023095-4dannjjm 3052 1 There there EX cord-023095-4dannjjm 3052 2 was be VBD cord-023095-4dannjjm 3052 3 no no DT cord-023095-4dannjjm 3052 4 statistically statistically RB cord-023095-4dannjjm 3052 5 significant significant JJ cord-023095-4dannjjm 3052 6 relationship relationship NN cord-023095-4dannjjm 3052 7 , , , cord-023095-4dannjjm 3052 8 either either CC cord-023095-4dannjjm 3052 9 categorically categorically RB cord-023095-4dannjjm 3052 10 or or CC cord-023095-4dannjjm 3052 11 continuously continuously RB cord-023095-4dannjjm 3052 12 , , , cord-023095-4dannjjm 3052 13 in in IN cord-023095-4dannjjm 3052 14 univariate univariate JJ cord-023095-4dannjjm 3052 15 as as RB cord-023095-4dannjjm 3052 16 well well RB cord-023095-4dannjjm 3052 17 as as IN cord-023095-4dannjjm 3052 18 multivariate multivariate JJ cord-023095-4dannjjm 3052 19 analyses analysis NNS cord-023095-4dannjjm 3052 20 of of IN cord-023095-4dannjjm 3052 21 all all DT cord-023095-4dannjjm 3052 22 variables variable NNS cord-023095-4dannjjm 3052 23 . . . cord-023095-4dannjjm 3053 1 Univariate univariate JJ cord-023095-4dannjjm 3053 2 logistic logistic JJ cord-023095-4dannjjm 3053 3 regression regression NN cord-023095-4dannjjm 3053 4 ( ( -LRB- cord-023095-4dannjjm 3053 5 odds odd NNS cord-023095-4dannjjm 3053 6 ratio ratio NN cord-023095-4dannjjm 3053 7 ; ; : cord-023095-4dannjjm 3053 8 lower low JJR cord-023095-4dannjjm 3053 9 and and CC cord-023095-4dannjjm 3053 10 upper upper JJ cord-023095-4dannjjm 3053 11 confidence confidence NN cord-023095-4dannjjm 3053 12 limit limit NN cord-023095-4dannjjm 3053 13 ; ; : cord-023095-4dannjjm 3053 14 P p NN cord-023095-4dannjjm 3053 15 value value NN cord-023095-4dannjjm 3053 16 ) ) -RRB- cord-023095-4dannjjm 3053 17 for for IN cord-023095-4dannjjm 3053 18 hypertension hypertension NN cord-023095-4dannjjm 3053 19 was be VBD cord-023095-4dannjjm 3053 20 À1.18 À1.18 VBN cord-023095-4dannjjm 3053 21 ; ; : cord-023095-4dannjjm 3053 22 0.201 0.201 CD cord-023095-4dannjjm 3053 23 , , , cord-023095-4dannjjm 3053 24 6.99 6.99 CD cord-023095-4dannjjm 3053 25 ; ; : cord-023095-4dannjjm 3053 26 0.851 0.851 CD cord-023095-4dannjjm 3053 27 ; ; : cord-023095-4dannjjm 3053 28 for for IN cord-023095-4dannjjm 3053 29 albumin albumin NN cord-023095-4dannjjm 3053 30 -1.37 -1.37 CD cord-023095-4dannjjm 3053 31 ; ; : cord-023095-4dannjjm 3053 32 0.228 0.228 CD cord-023095-4dannjjm 3053 33 , , , cord-023095-4dannjjm 3053 34 8.26 8.26 CD cord-023095-4dannjjm 3053 35 ; ; : cord-023095-4dannjjm 3053 36 0.728 0.728 CD cord-023095-4dannjjm 3053 37 ; ; : cord-023095-4dannjjm 3053 38 and and CC cord-023095-4dannjjm 3053 39 for for IN cord-023095-4dannjjm 3053 40 antithrombin antithrombin NN cord-023095-4dannjjm 3053 41 activity activity NN cord-023095-4dannjjm 3053 42 -0.73 -0.73 CD cord-023095-4dannjjm 3053 43 ; ; : cord-023095-4dannjjm 3053 44 0.12 0.12 CD cord-023095-4dannjjm 3053 45 , , , cord-023095-4dannjjm 3053 46 4.39 4.39 CD cord-023095-4dannjjm 3053 47 ; ; : cord-023095-4dannjjm 3053 48 0.728 0.728 CD cord-023095-4dannjjm 3053 49 . . . cord-023095-4dannjjm 3054 1 Thus thus RB cord-023095-4dannjjm 3054 2 , , , cord-023095-4dannjjm 3054 3 in in IN cord-023095-4dannjjm 3054 4 this this DT cord-023095-4dannjjm 3054 5 patient patient JJ cord-023095-4dannjjm 3054 6 population population NN cord-023095-4dannjjm 3054 7 , , , cord-023095-4dannjjm 3054 8 in in IN cord-023095-4dannjjm 3054 9 the the DT cord-023095-4dannjjm 3054 10 absence absence NN cord-023095-4dannjjm 3054 11 of of IN cord-023095-4dannjjm 3054 12 TEG TEG NNP cord-023095-4dannjjm 3054 13 , , , cord-023095-4dannjjm 3054 14 prediction prediction NN cord-023095-4dannjjm 3054 15 of of IN cord-023095-4dannjjm 3054 16 hypercoagulability hypercoagulability NN cord-023095-4dannjjm 3054 17 using use VBG cord-023095-4dannjjm 3054 18 abnormalities abnormality NNS cord-023095-4dannjjm 3054 19 in in IN cord-023095-4dannjjm 3054 20 commonly commonly RB cord-023095-4dannjjm 3054 21 measured measure VBN cord-023095-4dannjjm 3054 22 clinicopathologic clinicopathologic JJ cord-023095-4dannjjm 3054 23 variables variable NNS cord-023095-4dannjjm 3054 24 was be VBD cord-023095-4dannjjm 3054 25 not not RB cord-023095-4dannjjm 3054 26 helpful helpful JJ cord-023095-4dannjjm 3054 27 . . . cord-023095-4dannjjm 3055 1 However however RB cord-023095-4dannjjm 3055 2 , , , cord-023095-4dannjjm 3055 3 given give VBN cord-023095-4dannjjm 3055 4 the the DT cord-023095-4dannjjm 3055 5 documented document VBN cord-023095-4dannjjm 3055 6 high high JJ cord-023095-4dannjjm 3055 7 prevalence prevalence NN cord-023095-4dannjjm 3055 8 of of IN cord-023095-4dannjjm 3055 9 hypercoagulability hypercoagulability NN cord-023095-4dannjjm 3055 10 in in IN cord-023095-4dannjjm 3055 11 patients patient NNS cord-023095-4dannjjm 3055 12 with with IN cord-023095-4dannjjm 3055 13 PLN PLN NNP cord-023095-4dannjjm 3055 14 , , , cord-023095-4dannjjm 3055 15 early early JJ cord-023095-4dannjjm 3055 16 institution institution NN cord-023095-4dannjjm 3055 17 of of IN cord-023095-4dannjjm 3055 18 prophylactic prophylactic JJ cord-023095-4dannjjm 3055 19 anti anti JJ cord-023095-4dannjjm 3055 20 - - JJ cord-023095-4dannjjm 3055 21 platelet platelet JJ cord-023095-4dannjjm 3055 22 or or CC cord-023095-4dannjjm 3055 23 anticoagulant anticoagulant JJ cord-023095-4dannjjm 3055 24 therapies therapy NNS cord-023095-4dannjjm 3055 25 should should MD cord-023095-4dannjjm 3055 26 be be VB cord-023095-4dannjjm 3055 27 considered consider VBN cord-023095-4dannjjm 3055 28 . . . cord-023095-4dannjjm 3056 1 Thromboelastography Thromboelastography NNP cord-023095-4dannjjm 3056 2 ( ( -LRB- cord-023095-4dannjjm 3056 3 TEG TEG NNP cord-023095-4dannjjm 3056 4 ) ) -RRB- cord-023095-4dannjjm 3056 5 is be VBZ cord-023095-4dannjjm 3056 6 a a DT cord-023095-4dannjjm 3056 7 test test NN cord-023095-4dannjjm 3056 8 of of IN cord-023095-4dannjjm 3056 9 global global JJ cord-023095-4dannjjm 3056 10 hemostasis hemostasis NN cord-023095-4dannjjm 3056 11 . . . cord-023095-4dannjjm 3057 1 Due due IN cord-023095-4dannjjm 3057 2 to to IN cord-023095-4dannjjm 3057 3 the the DT cord-023095-4dannjjm 3057 4 effects effect NNS cord-023095-4dannjjm 3057 5 of of IN cord-023095-4dannjjm 3057 6 extrinsic extrinsic JJ cord-023095-4dannjjm 3057 7 factors factor NNS cord-023095-4dannjjm 3057 8 on on IN cord-023095-4dannjjm 3057 9 whole whole JJ cord-023095-4dannjjm 3057 10 blood blood NN cord-023095-4dannjjm 3057 11 coagulation coagulation NN cord-023095-4dannjjm 3057 12 , , , cord-023095-4dannjjm 3057 13 sample sample NN cord-023095-4dannjjm 3057 14 collection collection NN cord-023095-4dannjjm 3057 15 method method NN cord-023095-4dannjjm 3057 16 ( ( -LRB- cord-023095-4dannjjm 3057 17 SCM SCM NNP cord-023095-4dannjjm 3057 18 ) ) -RRB- cord-023095-4dannjjm 3057 19 may may MD cord-023095-4dannjjm 3057 20 influence influence VB cord-023095-4dannjjm 3057 21 results result NNS cord-023095-4dannjjm 3057 22 . . . cord-023095-4dannjjm 3058 1 The the DT cord-023095-4dannjjm 3058 2 purpose purpose NN cord-023095-4dannjjm 3058 3 was be VBD cord-023095-4dannjjm 3058 4 to to TO cord-023095-4dannjjm 3058 5 determine determine VB cord-023095-4dannjjm 3058 6 if if IN cord-023095-4dannjjm 3058 7 SCM SCM NNP cord-023095-4dannjjm 3058 8 influenced influence VBD cord-023095-4dannjjm 3058 9 TEG TEG NNP cord-023095-4dannjjm 3058 10 using use VBG cord-023095-4dannjjm 3058 11 kaolin kaolin NN cord-023095-4dannjjm 3058 12 - - HYPH cord-023095-4dannjjm 3058 13 activated activate VBN cord-023095-4dannjjm 3058 14 citrated citrate VBN cord-023095-4dannjjm 3058 15 whole whole JJ cord-023095-4dannjjm 3058 16 blood blood NN cord-023095-4dannjjm 3058 17 ( ( -LRB- cord-023095-4dannjjm 3058 18 WB WB NNP cord-023095-4dannjjm 3058 19 ) ) -RRB- cord-023095-4dannjjm 3058 20 . . . cord-023095-4dannjjm 3059 1 Healthy healthy JJ cord-023095-4dannjjm 3059 2 dogs dog NNS cord-023095-4dannjjm 3059 3 with with IN cord-023095-4dannjjm 3059 4 normal normal JJ cord-023095-4dannjjm 3059 5 platelet platelet NN cord-023095-4dannjjm 3059 6 counts count NNS cord-023095-4dannjjm 3059 7 were be VBD cord-023095-4dannjjm 3059 8 prospectively prospectively RB cord-023095-4dannjjm 3059 9 enrolled enrol VBN cord-023095-4dannjjm 3059 10 . . . cord-023095-4dannjjm 3060 1 Three three CD cord-023095-4dannjjm 3060 2 WB WB NNP cord-023095-4dannjjm 3060 3 samples sample NNS cord-023095-4dannjjm 3060 4 were be VBD cord-023095-4dannjjm 3060 5 obtained obtain VBN cord-023095-4dannjjm 3060 6 from from IN cord-023095-4dannjjm 3060 7 each each DT cord-023095-4dannjjm 3060 8 dog dog NN cord-023095-4dannjjm 3060 9 at at IN cord-023095-4dannjjm 3060 10 least least JJS cord-023095-4dannjjm 3060 11 48 48 CD cord-023095-4dannjjm 3060 12 hours hour NNS cord-023095-4dannjjm 3060 13 apart apart RB cord-023095-4dannjjm 3060 14 from from IN cord-023095-4dannjjm 3060 15 alternating alternate VBG cord-023095-4dannjjm 3060 16 jugular jugular NN cord-023095-4dannjjm 3060 17 veins vein NNS cord-023095-4dannjjm 3060 18 in in IN cord-023095-4dannjjm 3060 19 a a DT cord-023095-4dannjjm 3060 20 randomized randomized JJ cord-023095-4dannjjm 3060 21 order order NN cord-023095-4dannjjm 3060 22 of of IN cord-023095-4dannjjm 3060 23 three three CD cord-023095-4dannjjm 3060 24 methods method NNS cord-023095-4dannjjm 3060 25 : : : cord-023095-4dannjjm 3060 26 1 1 LS cord-023095-4dannjjm 3060 27 ) ) -RRB- cord-023095-4dannjjm 3060 28 vacutainer vacutainer NNP cord-023095-4dannjjm 3060 29 s s VBZ cord-023095-4dannjjm 3060 30 into into IN cord-023095-4dannjjm 3060 31 citrated citrated JJ cord-023095-4dannjjm 3060 32 tube tube NN cord-023095-4dannjjm 3060 33 ( ( -LRB- cord-023095-4dannjjm 3060 34 VAC VAC NNP cord-023095-4dannjjm 3060 35 ) ) -RRB- cord-023095-4dannjjm 3060 36 , , , cord-023095-4dannjjm 3060 37 2 2 CD cord-023095-4dannjjm 3060 38 ) ) -RRB- cord-023095-4dannjjm 3060 39 citrated citrate VBN cord-023095-4dannjjm 3060 40 syringe syringe NN cord-023095-4dannjjm 3060 41 with with IN cord-023095-4dannjjm 3060 42 transfer transfer NN cord-023095-4dannjjm 3060 43 into into IN cord-023095-4dannjjm 3060 44 plain plain JJ cord-023095-4dannjjm 3060 45 tube tube NN cord-023095-4dannjjm 3060 46 ( ( -LRB- cord-023095-4dannjjm 3060 47 CIT CIT NNP cord-023095-4dannjjm 3060 48 ) ) -RRB- cord-023095-4dannjjm 3060 49 , , , cord-023095-4dannjjm 3060 50 or or CC cord-023095-4dannjjm 3060 51 3 3 LS cord-023095-4dannjjm 3060 52 ) ) -RRB- cord-023095-4dannjjm 3060 53 plain plain JJ cord-023095-4dannjjm 3060 54 syringe syringe NN cord-023095-4dannjjm 3060 55 with with IN cord-023095-4dannjjm 3060 56 transfer transfer NN cord-023095-4dannjjm 3060 57 into into IN cord-023095-4dannjjm 3060 58 citrated citrated JJ cord-023095-4dannjjm 3060 59 tube tube NN cord-023095-4dannjjm 3060 60 ( ( -LRB- cord-023095-4dannjjm 3060 61 PLAIN PLAIN NNP cord-023095-4dannjjm 3060 62 ) ) -RRB- cord-023095-4dannjjm 3060 63 . . . cord-023095-4dannjjm 3061 1 Draw draw VB cord-023095-4dannjjm 3061 2 time time NN cord-023095-4dannjjm 3061 3 was be VBD cord-023095-4dannjjm 3061 4 recorded record VBN cord-023095-4dannjjm 3061 5 in in IN cord-023095-4dannjjm 3061 6 seconds second NNS cord-023095-4dannjjm 3061 7 . . . cord-023095-4dannjjm 3062 1 Kaolin kaolin NN cord-023095-4dannjjm 3062 2 - - HYPH cord-023095-4dannjjm 3062 3 activated activate VBN cord-023095-4dannjjm 3062 4 TEG TEG NNP cord-023095-4dannjjm 3062 5 was be VBD cord-023095-4dannjjm 3062 6 performed perform VBN cord-023095-4dannjjm 3062 7 , , , cord-023095-4dannjjm 3062 8 with with IN cord-023095-4dannjjm 3062 9 measurement measurement NN cord-023095-4dannjjm 3062 10 of of IN cord-023095-4dannjjm 3062 11 reaction reaction NN cord-023095-4dannjjm 3062 12 time time NN cord-023095-4dannjjm 3062 13 ( ( -LRB- cord-023095-4dannjjm 3062 14 R r NN cord-023095-4dannjjm 3062 15 ) ) -RRB- cord-023095-4dannjjm 3062 16 , , , cord-023095-4dannjjm 3062 17 clot clot NN cord-023095-4dannjjm 3062 18 formation formation NN cord-023095-4dannjjm 3062 19 time time NN cord-023095-4dannjjm 3062 20 ( ( -LRB- cord-023095-4dannjjm 3062 21 K K NNP cord-023095-4dannjjm 3062 22 ) ) -RRB- cord-023095-4dannjjm 3062 23 , , , cord-023095-4dannjjm 3062 24 maximum maximum JJ cord-023095-4dannjjm 3062 25 amplitude amplitude NN cord-023095-4dannjjm 3062 26 ( ( -LRB- cord-023095-4dannjjm 3062 27 MA MA NNP cord-023095-4dannjjm 3062 28 ) ) -RRB- cord-023095-4dannjjm 3062 29 , , , cord-023095-4dannjjm 3062 30 and and CC cord-023095-4dannjjm 3062 31 alpha alpha NN cord-023095-4dannjjm 3062 32 angle angle NN cord-023095-4dannjjm 3062 33 . . . cord-023095-4dannjjm 3063 1 Eleven eleven CD cord-023095-4dannjjm 3063 2 dogs dog NNS cord-023095-4dannjjm 3063 3 were be VBD cord-023095-4dannjjm 3063 4 enrolled enrol VBN cord-023095-4dannjjm 3063 5 . . . cord-023095-4dannjjm 3064 1 There there EX cord-023095-4dannjjm 3064 2 were be VBD cord-023095-4dannjjm 3064 3 no no DT cord-023095-4dannjjm 3064 4 significant significant JJ cord-023095-4dannjjm 3064 5 differences difference NNS cord-023095-4dannjjm 3064 6 in in IN cord-023095-4dannjjm 3064 7 TEG TEG NNP cord-023095-4dannjjm 3064 8 indices index NNS cord-023095-4dannjjm 3064 9 between between IN cord-023095-4dannjjm 3064 10 VAC vac NN cord-023095-4dannjjm 3064 11 samples sample NNS cord-023095-4dannjjm 3064 12 and and CC cord-023095-4dannjjm 3064 13 either either CC cord-023095-4dannjjm 3064 14 CIT CIT NNP cord-023095-4dannjjm 3064 15 or or CC cord-023095-4dannjjm 3064 16 PLAIN plain JJ cord-023095-4dannjjm 3064 17 samples sample NNS cord-023095-4dannjjm 3064 18 . . . cord-023095-4dannjjm 3065 1 CIT CIT NNP cord-023095-4dannjjm 3065 2 samples sample NNS cord-023095-4dannjjm 3065 3 had have VBD cord-023095-4dannjjm 3065 4 a a DT cord-023095-4dannjjm 3065 5 significantly significantly RB cord-023095-4dannjjm 3065 6 higher high JJR cord-023095-4dannjjm 3065 7 K K NNP cord-023095-4dannjjm 3065 8 value value NN cord-023095-4dannjjm 3065 9 ( ( -LRB- cord-023095-4dannjjm 3065 10 p p NN cord-023095-4dannjjm 3065 11 5 5 CD cord-023095-4dannjjm 3065 12 0.004 0.004 CD cord-023095-4dannjjm 3065 13 ) ) -RRB- cord-023095-4dannjjm 3065 14 and and CC cord-023095-4dannjjm 3065 15 a a DT cord-023095-4dannjjm 3065 16 lower low JJR cord-023095-4dannjjm 3065 17 alpha alpha NN cord-023095-4dannjjm 3065 18 angle angle NN cord-023095-4dannjjm 3065 19 ( ( -LRB- cord-023095-4dannjjm 3065 20 p p NN cord-023095-4dannjjm 3065 21 5 5 CD cord-023095-4dannjjm 3065 22 0.004 0.004 CD cord-023095-4dannjjm 3065 23 ) ) -RRB- cord-023095-4dannjjm 3065 24 compared compare VBN cord-023095-4dannjjm 3065 25 to to IN cord-023095-4dannjjm 3065 26 PLAIN plain JJ cord-023095-4dannjjm 3065 27 samples sample NNS cord-023095-4dannjjm 3065 28 . . . cord-023095-4dannjjm 3066 1 Draw draw VB cord-023095-4dannjjm 3066 2 times time NNS cord-023095-4dannjjm 3066 3 ranged range VBD cord-023095-4dannjjm 3066 4 from from IN cord-023095-4dannjjm 3066 5 2 2 CD cord-023095-4dannjjm 3066 6 - - SYM cord-023095-4dannjjm 3066 7 10 10 CD cord-023095-4dannjjm 3066 8 seconds second NNS cord-023095-4dannjjm 3066 9 . . . cord-023095-4dannjjm 3067 1 A a DT cord-023095-4dannjjm 3067 2 longer longer RB cord-023095-4dannjjm 3067 3 draw draw VBP cord-023095-4dannjjm 3067 4 time time NN cord-023095-4dannjjm 3067 5 was be VBD cord-023095-4dannjjm 3067 6 significantly significantly RB cord-023095-4dannjjm 3067 7 correlated correlate VBN cord-023095-4dannjjm 3067 8 ( ( -LRB- cord-023095-4dannjjm 3067 9 p p NN cord-023095-4dannjjm 3067 10 5 5 CD cord-023095-4dannjjm 3067 11 0.046 0.046 CD cord-023095-4dannjjm 3067 12 ; ; : cord-023095-4dannjjm 3068 1 R r NN cord-023095-4dannjjm 3068 2 5 5 CD cord-023095-4dannjjm 3068 3 À0.35 À0.35 NNP cord-023095-4dannjjm 3068 4 ) ) -RRB- cord-023095-4dannjjm 3068 5 with with IN cord-023095-4dannjjm 3068 6 a a DT cord-023095-4dannjjm 3068 7 shorter short JJR cord-023095-4dannjjm 3068 8 R r NN cord-023095-4dannjjm 3068 9 time time NN cord-023095-4dannjjm 3068 10 . . . cord-023095-4dannjjm 3069 1 Higher high JJR cord-023095-4dannjjm 3069 2 platelet platelet NN cord-023095-4dannjjm 3069 3 count count NN cord-023095-4dannjjm 3069 4 was be VBD cord-023095-4dannjjm 3069 5 significantly significantly RB cord-023095-4dannjjm 3069 6 correlated correlate VBN cord-023095-4dannjjm 3069 7 ( ( -LRB- cord-023095-4dannjjm 3069 8 p p NN cord-023095-4dannjjm 3069 9 5 5 CD cord-023095-4dannjjm 3069 10 0.001 0.001 CD cord-023095-4dannjjm 3069 11 ; ; : cord-023095-4dannjjm 3069 12 R r NN cord-023095-4dannjjm 3069 13 5 5 CD cord-023095-4dannjjm 3069 14 0.575 0.575 CD cord-023095-4dannjjm 3069 15 ) ) -RRB- cord-023095-4dannjjm 3069 16 with with IN cord-023095-4dannjjm 3069 17 a a DT cord-023095-4dannjjm 3069 18 higher high JJR cord-023095-4dannjjm 3069 19 MA MA NNP cord-023095-4dannjjm 3069 20 . . . cord-023095-4dannjjm 3070 1 SCM SCM NNP cord-023095-4dannjjm 3070 2 did do VBD cord-023095-4dannjjm 3070 3 not not RB cord-023095-4dannjjm 3070 4 have have VB cord-023095-4dannjjm 3070 5 a a DT cord-023095-4dannjjm 3070 6 significant significant JJ cord-023095-4dannjjm 3070 7 effect effect NN cord-023095-4dannjjm 3070 8 on on IN cord-023095-4dannjjm 3070 9 TEG TEG NNP cord-023095-4dannjjm 3070 10 parameters parameter NNS cord-023095-4dannjjm 3070 11 when when WRB cord-023095-4dannjjm 3070 12 comparing compare VBG cord-023095-4dannjjm 3070 13 VAC vac NN cord-023095-4dannjjm 3070 14 samples sample NNS cord-023095-4dannjjm 3070 15 to to IN cord-023095-4dannjjm 3070 16 either either CC cord-023095-4dannjjm 3070 17 CIT CIT NNP cord-023095-4dannjjm 3070 18 or or CC cord-023095-4dannjjm 3070 19 PLAIN plain JJ cord-023095-4dannjjm 3070 20 samples sample NNS cord-023095-4dannjjm 3070 21 . . . cord-023095-4dannjjm 3071 1 Minimizing minimize VBG cord-023095-4dannjjm 3071 2 sample sample NN cord-023095-4dannjjm 3071 3 collection collection NN cord-023095-4dannjjm 3071 4 time time NN cord-023095-4dannjjm 3071 5 and and CC cord-023095-4dannjjm 3071 6 trauma trauma NN cord-023095-4dannjjm 3071 7 during during IN cord-023095-4dannjjm 3071 8 venipuncture venipuncture NN cord-023095-4dannjjm 3071 9 may may MD cord-023095-4dannjjm 3071 10 be be VB cord-023095-4dannjjm 3071 11 important important JJ cord-023095-4dannjjm 3071 12 in in IN cord-023095-4dannjjm 3071 13 minimizing minimize VBG cord-023095-4dannjjm 3071 14 hypercoagulable hypercoagulable JJ cord-023095-4dannjjm 3071 15 changes change NNS cord-023095-4dannjjm 3071 16 in in IN cord-023095-4dannjjm 3071 17 TEG TEG NNP cord-023095-4dannjjm 3071 18 indices index NNS cord-023095-4dannjjm 3071 19 . . . cord-023095-4dannjjm 3072 1 Liquid liquid NN cord-023095-4dannjjm 3072 2 plasma plasma NN cord-023095-4dannjjm 3072 3 ( ( -LRB- cord-023095-4dannjjm 3072 4 LP LP NNP cord-023095-4dannjjm 3072 5 ) ) -RRB- cord-023095-4dannjjm 3072 6 is be VBZ cord-023095-4dannjjm 3072 7 defined define VBN cord-023095-4dannjjm 3072 8 as as IN cord-023095-4dannjjm 3072 9 either either DT cord-023095-4dannjjm 3072 10 plasma plasma NN cord-023095-4dannjjm 3072 11 collected collect VBD cord-023095-4dannjjm 3072 12 and and CC cord-023095-4dannjjm 3072 13 refrigerated refrigerate VBN cord-023095-4dannjjm 3072 14 immediately immediately RB cord-023095-4dannjjm 3072 15 after after IN cord-023095-4dannjjm 3072 16 collection collection NN cord-023095-4dannjjm 3072 17 or or CC cord-023095-4dannjjm 3072 18 fresh fresh JJ cord-023095-4dannjjm 3072 19 frozen frozen JJ cord-023095-4dannjjm 3072 20 plasma plasma NN cord-023095-4dannjjm 3072 21 ( ( -LRB- cord-023095-4dannjjm 3072 22 FFP FFP NNP cord-023095-4dannjjm 3072 23 ) ) -RRB- cord-023095-4dannjjm 3072 24 that that WDT cord-023095-4dannjjm 3072 25 is be VBZ cord-023095-4dannjjm 3072 26 thawed thaw VBN cord-023095-4dannjjm 3072 27 and and CC cord-023095-4dannjjm 3072 28 stored store VBN cord-023095-4dannjjm 3072 29 refrigerated refrigerated JJ cord-023095-4dannjjm 3072 30 until until IN cord-023095-4dannjjm 3072 31 use use NN cord-023095-4dannjjm 3072 32 . . . cord-023095-4dannjjm 3073 1 Stability stability NN cord-023095-4dannjjm 3073 2 studies study NNS cord-023095-4dannjjm 3073 3 in in IN cord-023095-4dannjjm 3073 4 people people NNS cord-023095-4dannjjm 3073 5 have have VBP cord-023095-4dannjjm 3073 6 shown show VBN cord-023095-4dannjjm 3073 7 that that IN cord-023095-4dannjjm 3073 8 adequate adequate JJ cord-023095-4dannjjm 3073 9 clotting clotting NN cord-023095-4dannjjm 3073 10 factor factor NN cord-023095-4dannjjm 3073 11 activity activity NN cord-023095-4dannjjm 3073 12 is be VBZ cord-023095-4dannjjm 3073 13 preserved preserve VBN cord-023095-4dannjjm 3073 14 for for IN cord-023095-4dannjjm 3073 15 at at RB cord-023095-4dannjjm 3073 16 least least RBS cord-023095-4dannjjm 3073 17 14 14 CD cord-023095-4dannjjm 3073 18 days day NNS cord-023095-4dannjjm 3073 19 . . . cord-023095-4dannjjm 3074 1 LP LP NNP cord-023095-4dannjjm 3074 2 is be VBZ cord-023095-4dannjjm 3074 3 transfused transfuse VBN cord-023095-4dannjjm 3074 4 in in IN cord-023095-4dannjjm 3074 5 human human JJ cord-023095-4dannjjm 3074 6 Level level NN cord-023095-4dannjjm 3074 7 I I NNP cord-023095-4dannjjm 3074 8 trauma trauma NN cord-023095-4dannjjm 3074 9 centers center NNS cord-023095-4dannjjm 3074 10 to to TO cord-023095-4dannjjm 3074 11 critically critically RB cord-023095-4dannjjm 3074 12 ill ill VB cord-023095-4dannjjm 3074 13 people people NNS cord-023095-4dannjjm 3074 14 requiring require VBG cord-023095-4dannjjm 3074 15 rapid rapid JJ cord-023095-4dannjjm 3074 16 infusion infusion NN cord-023095-4dannjjm 3074 17 of of IN cord-023095-4dannjjm 3074 18 clotting clotting NN cord-023095-4dannjjm 3074 19 factors factor NNS cord-023095-4dannjjm 3074 20 as as IN cord-023095-4dannjjm 3074 21 the the DT cord-023095-4dannjjm 3074 22 time time NN cord-023095-4dannjjm 3074 23 required require VBN cord-023095-4dannjjm 3074 24 to to TO cord-023095-4dannjjm 3074 25 defrost defrost VB cord-023095-4dannjjm 3074 26 FFP FFP NNP cord-023095-4dannjjm 3074 27 is be VBZ cord-023095-4dannjjm 3074 28 considered consider VBN cord-023095-4dannjjm 3074 29 prohibitive prohibitive JJ cord-023095-4dannjjm 3074 30 . . . cord-023095-4dannjjm 3075 1 The the DT cord-023095-4dannjjm 3075 2 use use NN cord-023095-4dannjjm 3075 3 of of IN cord-023095-4dannjjm 3075 4 LP LP NNP cord-023095-4dannjjm 3075 5 has have VBZ cord-023095-4dannjjm 3075 6 not not RB cord-023095-4dannjjm 3075 7 been be VBN cord-023095-4dannjjm 3075 8 described describe VBN cord-023095-4dannjjm 3075 9 in in IN cord-023095-4dannjjm 3075 10 veterinary veterinary JJ cord-023095-4dannjjm 3075 11 critical critical JJ cord-023095-4dannjjm 3075 12 care care NN cord-023095-4dannjjm 3075 13 . . . cord-023095-4dannjjm 3076 1 The the DT cord-023095-4dannjjm 3076 2 purposes purpose NNS cord-023095-4dannjjm 3076 3 of of IN cord-023095-4dannjjm 3076 4 this this DT cord-023095-4dannjjm 3076 5 study study NN cord-023095-4dannjjm 3076 6 were be VBD cord-023095-4dannjjm 3076 7 to to IN cord-023095-4dannjjm 3076 8 1 1 CD cord-023095-4dannjjm 3076 9 ) ) -RRB- cord-023095-4dannjjm 3076 10 determine determine VB cord-023095-4dannjjm 3076 11 the the DT cord-023095-4dannjjm 3076 12 length length NN cord-023095-4dannjjm 3076 13 of of IN cord-023095-4dannjjm 3076 14 time time NN cord-023095-4dannjjm 3076 15 required require VBN cord-023095-4dannjjm 3076 16 in in IN cord-023095-4dannjjm 3076 17 a a DT cord-023095-4dannjjm 3076 18 water water NN cord-023095-4dannjjm 3076 19 bath bath NN cord-023095-4dannjjm 3076 20 for for IN cord-023095-4dannjjm 3076 21 a a DT cord-023095-4dannjjm 3076 22 unit unit NN cord-023095-4dannjjm 3076 23 of of IN cord-023095-4dannjjm 3076 24 canine canine JJ cord-023095-4dannjjm 3076 25 FFP FFP NNP cord-023095-4dannjjm 3076 26 to to TO cord-023095-4dannjjm 3076 27 thaw thaw VB cord-023095-4dannjjm 3076 28 and and CC cord-023095-4dannjjm 3076 29 2 2 LS cord-023095-4dannjjm 3076 30 ) ) -RRB- cord-023095-4dannjjm 3076 31 describe describe VBP cord-023095-4dannjjm 3076 32 the the DT cord-023095-4dannjjm 3076 33 use use NN cord-023095-4dannjjm 3076 34 of of IN cord-023095-4dannjjm 3076 35 LP LP NNP cord-023095-4dannjjm 3076 36 in in IN cord-023095-4dannjjm 3076 37 a a DT cord-023095-4dannjjm 3076 38 busy busy JJ cord-023095-4dannjjm 3076 39 university university NN cord-023095-4dannjjm 3076 40 emergency emergency NN cord-023095-4dannjjm 3076 41 room room NN cord-023095-4dannjjm 3076 42 ( ( -LRB- cord-023095-4dannjjm 3076 43 ER ER NNP cord-023095-4dannjjm 3076 44 ) ) -RRB- cord-023095-4dannjjm 3076 45 . . . cord-023095-4dannjjm 3077 1 For for IN cord-023095-4dannjjm 3077 2 part part NN cord-023095-4dannjjm 3077 3 1 1 CD cord-023095-4dannjjm 3077 4 : : : cord-023095-4dannjjm 3077 5 Six six CD cord-023095-4dannjjm 3077 6 units unit NNS cord-023095-4dannjjm 3077 7 ( ( -LRB- cord-023095-4dannjjm 3077 8 250 250 CD cord-023095-4dannjjm 3077 9 ml ml NNS cord-023095-4dannjjm 3077 10 ) ) -RRB- cord-023095-4dannjjm 3077 11 of of IN cord-023095-4dannjjm 3077 12 canine canine JJ cord-023095-4dannjjm 3077 13 FFP FFP NNP cord-023095-4dannjjm 3077 14 were be VBD cord-023095-4dannjjm 3077 15 individually individually RB cord-023095-4dannjjm 3077 16 thawed thaw VBN cord-023095-4dannjjm 3077 17 in in IN cord-023095-4dannjjm 3077 18 a a DT cord-023095-4dannjjm 3077 19 371C 371c CD cord-023095-4dannjjm 3077 20 water water NN cord-023095-4dannjjm 3077 21 bath bath NN cord-023095-4dannjjm 3077 22 . . . cord-023095-4dannjjm 3078 1 The the DT cord-023095-4dannjjm 3078 2 duration duration NN cord-023095-4dannjjm 3078 3 of of IN cord-023095-4dannjjm 3078 4 time time NN cord-023095-4dannjjm 3078 5 ( ( -LRB- cord-023095-4dannjjm 3078 6 in in IN cord-023095-4dannjjm 3078 7 minutes minute NNS cord-023095-4dannjjm 3078 8 ) ) -RRB- cord-023095-4dannjjm 3078 9 to to TO cord-023095-4dannjjm 3078 10 thaw thaw VB cord-023095-4dannjjm 3078 11 was be VBD cord-023095-4dannjjm 3078 12 recorded record VBN cord-023095-4dannjjm 3078 13 . . . cord-023095-4dannjjm 3079 1 For for IN cord-023095-4dannjjm 3079 2 part part NN cord-023095-4dannjjm 3079 3 2 2 CD cord-023095-4dannjjm 3079 4 : : : cord-023095-4dannjjm 3079 5 The the DT cord-023095-4dannjjm 3079 6 transfusion transfusion NN cord-023095-4dannjjm 3079 7 log log NN cord-023095-4dannjjm 3079 8 was be VBD cord-023095-4dannjjm 3079 9 reviewed review VBN cord-023095-4dannjjm 3079 10 for for IN cord-023095-4dannjjm 3079 11 dogs dog NNS cord-023095-4dannjjm 3079 12 receiving receive VBG cord-023095-4dannjjm 3079 13 LP LP NNP cord-023095-4dannjjm 3079 14 in in IN cord-023095-4dannjjm 3079 15 the the DT cord-023095-4dannjjm 3079 16 last last JJ cord-023095-4dannjjm 3079 17 6 6 CD cord-023095-4dannjjm 3079 18 months month NNS cord-023095-4dannjjm 3079 19 . . . cord-023095-4dannjjm 3080 1 The the DT cord-023095-4dannjjm 3080 2 indications indication NNS cord-023095-4dannjjm 3080 3 and and CC cord-023095-4dannjjm 3080 4 outcome outcome NN cord-023095-4dannjjm 3080 5 were be VBD cord-023095-4dannjjm 3080 6 recorded record VBN cord-023095-4dannjjm 3080 7 . . . cord-023095-4dannjjm 3081 1 The the DT cord-023095-4dannjjm 3081 2 mean mean JJ cord-023095-4dannjjm 3081 3 time time NN cord-023095-4dannjjm 3081 4 AE AE NNP cord-023095-4dannjjm 3081 5 SD SD NNP cord-023095-4dannjjm 3081 6 thaw thaw NN cord-023095-4dannjjm 3081 7 time time NN cord-023095-4dannjjm 3081 8 was be VBD cord-023095-4dannjjm 3081 9 34.7 34.7 CD cord-023095-4dannjjm 3081 10 AE AE NNP cord-023095-4dannjjm 3081 11 1.38 1.38 CD cord-023095-4dannjjm 3081 12 minutes minute NNS cord-023095-4dannjjm 3081 13 . . . cord-023095-4dannjjm 3082 1 Ten ten CD cord-023095-4dannjjm 3082 2 units unit NNS cord-023095-4dannjjm 3082 3 of of IN cord-023095-4dannjjm 3082 4 LP LP NNP cord-023095-4dannjjm 3082 5 were be VBD cord-023095-4dannjjm 3082 6 transfused transfuse VBN cord-023095-4dannjjm 3082 7 to to IN cord-023095-4dannjjm 3082 8 7 7 CD cord-023095-4dannjjm 3082 9 critically critically RB cord-023095-4dannjjm 3082 10 ill ill JJ cord-023095-4dannjjm 3082 11 or or CC cord-023095-4dannjjm 3082 12 injured injure VBN cord-023095-4dannjjm 3082 13 dogs dog NNS cord-023095-4dannjjm 3082 14 during during IN cord-023095-4dannjjm 3082 15 the the DT cord-023095-4dannjjm 3082 16 study study NN cord-023095-4dannjjm 3082 17 time time NN cord-023095-4dannjjm 3082 18 . . . cord-023095-4dannjjm 3083 1 Indications indication NNS cord-023095-4dannjjm 3083 2 for for IN cord-023095-4dannjjm 3083 3 LP LP NNP cord-023095-4dannjjm 3083 4 transfusion transfusion NN cord-023095-4dannjjm 3083 5 included include VBD cord-023095-4dannjjm 3083 6 hypovolemic hypovolemic JJ cord-023095-4dannjjm 3083 7 shock shock NN cord-023095-4dannjjm 3083 8 due due IN cord-023095-4dannjjm 3083 9 to to IN cord-023095-4dannjjm 3083 10 intra intra JJ cord-023095-4dannjjm 3083 11 - - JJ cord-023095-4dannjjm 3083 12 abdominal abdominal JJ cord-023095-4dannjjm 3083 13 hemorrhage hemorrhage NN cord-023095-4dannjjm 3083 14 in in IN cord-023095-4dannjjm 3083 15 6 6 CD cord-023095-4dannjjm 3083 16 dogs dog NNS cord-023095-4dannjjm 3083 17 ( ( -LRB- cord-023095-4dannjjm 3083 18 2 2 CD cord-023095-4dannjjm 3083 19 traumatic traumatic JJ cord-023095-4dannjjm 3083 20 , , , cord-023095-4dannjjm 3083 21 4 4 CD cord-023095-4dannjjm 3083 22 non non JJ cord-023095-4dannjjm 3083 23 - - JJ cord-023095-4dannjjm 3083 24 traumatic traumatic JJ cord-023095-4dannjjm 3083 25 ) ) -RRB- cord-023095-4dannjjm 3083 26 and and CC cord-023095-4dannjjm 3083 27 rapid rapid JJ cord-023095-4dannjjm 3083 28 correction correction NN cord-023095-4dannjjm 3083 29 of of IN cord-023095-4dannjjm 3083 30 hemorrhage hemorrhage NN cord-023095-4dannjjm 3083 31 following follow VBG cord-023095-4dannjjm 3083 32 parenteral parenteral JJ cord-023095-4dannjjm 3083 33 tissue tissue NN cord-023095-4dannjjm 3083 34 plasminogen plasminogen NN cord-023095-4dannjjm 3083 35 activator activator NN cord-023095-4dannjjm 3083 36 administration administration NN cord-023095-4dannjjm 3083 37 in in IN cord-023095-4dannjjm 3083 38 1 1 CD cord-023095-4dannjjm 3083 39 dog dog NN cord-023095-4dannjjm 3083 40 . . . cord-023095-4dannjjm 3084 1 LP LP NNP cord-023095-4dannjjm 3084 2 volume volume NN cord-023095-4dannjjm 3084 3 transfused transfuse VBN cord-023095-4dannjjm 3084 4 ranged range VBD cord-023095-4dannjjm 3084 5 from from IN cord-023095-4dannjjm 3084 6 11.1 11.1 CD cord-023095-4dannjjm 3084 7 to to IN cord-023095-4dannjjm 3084 8 50.5 50.5 CD cord-023095-4dannjjm 3084 9 ml ml NNS cord-023095-4dannjjm 3084 10 / / SYM cord-023095-4dannjjm 3084 11 kg kg NN cord-023095-4dannjjm 3084 12 . . . cord-023095-4dannjjm 3085 1 No no DT cord-023095-4dannjjm 3085 2 transfusion transfusion NN cord-023095-4dannjjm 3085 3 reactions reaction NNS cord-023095-4dannjjm 3085 4 were be VBD cord-023095-4dannjjm 3085 5 identified identify VBN cord-023095-4dannjjm 3085 6 . . . cord-023095-4dannjjm 3086 1 Effect effect NN cord-023095-4dannjjm 3086 2 on on IN cord-023095-4dannjjm 3086 3 coagulation coagulation NN cord-023095-4dannjjm 3086 4 was be VBD cord-023095-4dannjjm 3086 5 not not RB cord-023095-4dannjjm 3086 6 consistently consistently RB cord-023095-4dannjjm 3086 7 evaluated evaluate VBN cord-023095-4dannjjm 3086 8 . . . cord-023095-4dannjjm 3087 1 Time time NN cord-023095-4dannjjm 3087 2 required require VBN cord-023095-4dannjjm 3087 3 to to TO cord-023095-4dannjjm 3087 4 thaw thaw VB cord-023095-4dannjjm 3087 5 a a DT cord-023095-4dannjjm 3087 6 unit unit NN cord-023095-4dannjjm 3087 7 of of IN cord-023095-4dannjjm 3087 8 FFP FFP NNP cord-023095-4dannjjm 3087 9 is be VBZ cord-023095-4dannjjm 3087 10 greater great JJR cord-023095-4dannjjm 3087 11 than than IN cord-023095-4dannjjm 3087 12 30 30 CD cord-023095-4dannjjm 3087 13 minutes minute NNS cord-023095-4dannjjm 3087 14 which which WDT cord-023095-4dannjjm 3087 15 could could MD cord-023095-4dannjjm 3087 16 be be VB cord-023095-4dannjjm 3087 17 detrimental detrimental JJ cord-023095-4dannjjm 3087 18 in in IN cord-023095-4dannjjm 3087 19 a a DT cord-023095-4dannjjm 3087 20 bleeding bleeding NN cord-023095-4dannjjm 3087 21 , , , cord-023095-4dannjjm 3087 22 coagulopathic coagulopathic JJ cord-023095-4dannjjm 3087 23 dog dog NN cord-023095-4dannjjm 3087 24 . . . cord-023095-4dannjjm 3088 1 LP LP NNP cord-023095-4dannjjm 3088 2 was be VBD cord-023095-4dannjjm 3088 3 transfused transfuse VBN cord-023095-4dannjjm 3088 4 without without IN cord-023095-4dannjjm 3088 5 incident incident NN cord-023095-4dannjjm 3088 6 to to TO cord-023095-4dannjjm 3088 7 critically critically RB cord-023095-4dannjjm 3088 8 ill ill VB cord-023095-4dannjjm 3088 9 and and CC cord-023095-4dannjjm 3088 10 injured injure VBN cord-023095-4dannjjm 3088 11 dogs dog NNS cord-023095-4dannjjm 3088 12 and and CC cord-023095-4dannjjm 3088 13 represents represent VBZ cord-023095-4dannjjm 3088 14 a a DT cord-023095-4dannjjm 3088 15 potential potential JJ cord-023095-4dannjjm 3088 16 new new JJ cord-023095-4dannjjm 3088 17 addition addition NN cord-023095-4dannjjm 3088 18 to to IN cord-023095-4dannjjm 3088 19 the the DT cord-023095-4dannjjm 3088 20 armamentarium armamentarium NN cord-023095-4dannjjm 3088 21 of of IN cord-023095-4dannjjm 3088 22 treatments treatment NNS cord-023095-4dannjjm 3088 23 in in IN cord-023095-4dannjjm 3088 24 a a DT cord-023095-4dannjjm 3088 25 veterinary veterinary JJ cord-023095-4dannjjm 3088 26 ER er NN cord-023095-4dannjjm 3088 27 setting setting NN cord-023095-4dannjjm 3088 28 . . . cord-023095-4dannjjm 3089 1 Further further JJ cord-023095-4dannjjm 3089 2 investigation investigation NN cord-023095-4dannjjm 3089 3 of of IN cord-023095-4dannjjm 3089 4 canine canine JJ cord-023095-4dannjjm 3089 5 LP LP NNP cord-023095-4dannjjm 3089 6 is be VBZ cord-023095-4dannjjm 3089 7 warranted warrant VBN cord-023095-4dannjjm 3089 8 including include VBG cord-023095-4dannjjm 3089 9 evaluation evaluation NN cord-023095-4dannjjm 3089 10 of of IN cord-023095-4dannjjm 3089 11 in in IN cord-023095-4dannjjm 3089 12 vitro vitro FW cord-023095-4dannjjm 3089 13 factor factor NN cord-023095-4dannjjm 3089 14 stability stability NN cord-023095-4dannjjm 3089 15 and and CC cord-023095-4dannjjm 3089 16 in in IN cord-023095-4dannjjm 3089 17 vivo vivo NN cord-023095-4dannjjm 3089 18 efficacy efficacy NN cord-023095-4dannjjm 3089 19 in in IN cord-023095-4dannjjm 3089 20 correcting correct VBG cord-023095-4dannjjm 3089 21 coagulopathy coagulopathy NN cord-023095-4dannjjm 3089 22 . . . cord-023095-4dannjjm 3090 1 Immune immune JJ cord-023095-4dannjjm 3090 2 mediated mediate VBN cord-023095-4dannjjm 3090 3 thrombocytopenia thrombocytopenia NN cord-023095-4dannjjm 3090 4 ( ( -LRB- cord-023095-4dannjjm 3090 5 IMT IMT NNP cord-023095-4dannjjm 3090 6 ) ) -RRB- cord-023095-4dannjjm 3090 7 is be VBZ cord-023095-4dannjjm 3090 8 associated associate VBN cord-023095-4dannjjm 3090 9 with with IN cord-023095-4dannjjm 3090 10 increased increase VBN cord-023095-4dannjjm 3090 11 morbidity morbidity NN cord-023095-4dannjjm 3090 12 and and CC cord-023095-4dannjjm 3090 13 mortality mortality NN cord-023095-4dannjjm 3090 14 . . . cord-023095-4dannjjm 3091 1 Large large JJ cord-023095-4dannjjm 3091 2 prospective prospective JJ cord-023095-4dannjjm 3091 3 research research NN cord-023095-4dannjjm 3091 4 studies study NNS cord-023095-4dannjjm 3091 5 in in IN cord-023095-4dannjjm 3091 6 dog dog NN cord-023095-4dannjjm 3091 7 platelet platelet NN cord-023095-4dannjjm 3091 8 antibodies antibody NNS cord-023095-4dannjjm 3091 9 and and CC cord-023095-4dannjjm 3091 10 clinical clinical JJ cord-023095-4dannjjm 3091 11 utilization utilization NN cord-023095-4dannjjm 3091 12 of of IN cord-023095-4dannjjm 3091 13 platelet platelet NN cord-023095-4dannjjm 3091 14 immunoglobulin immunoglobulin NN cord-023095-4dannjjm 3091 15 assays assay NNS cord-023095-4dannjjm 3091 16 are be VBP cord-023095-4dannjjm 3091 17 limited limited JJ cord-023095-4dannjjm 3091 18 . . . cord-023095-4dannjjm 3092 1 Potential potential JJ cord-023095-4dannjjm 3092 2 explanations explanation NNS cord-023095-4dannjjm 3092 3 include include VBP cord-023095-4dannjjm 3092 4 limited limited JJ cord-023095-4dannjjm 3092 5 availability availability NN cord-023095-4dannjjm 3092 6 and and CC cord-023095-4dannjjm 3092 7 low low JJ cord-023095-4dannjjm 3092 8 specificity specificity NN cord-023095-4dannjjm 3092 9 due due IN cord-023095-4dannjjm 3092 10 to to IN cord-023095-4dannjjm 3092 11 nonspecific nonspecific JJ cord-023095-4dannjjm 3092 12 binding binding NN cord-023095-4dannjjm 3092 13 . . . cord-023095-4dannjjm 3093 1 The the DT cord-023095-4dannjjm 3093 2 focus focus NN cord-023095-4dannjjm 3093 3 of of IN cord-023095-4dannjjm 3093 4 this this DT cord-023095-4dannjjm 3093 5 study study NN cord-023095-4dannjjm 3093 6 is be VBZ cord-023095-4dannjjm 3093 7 to to TO cord-023095-4dannjjm 3093 8 evaluate evaluate VB cord-023095-4dannjjm 3093 9 optimized optimize VBN cord-023095-4dannjjm 3093 10 direct direct JJ cord-023095-4dannjjm 3093 11 and and CC cord-023095-4dannjjm 3093 12 indirect indirect JJ cord-023095-4dannjjm 3093 13 platelet platelet NN cord-023095-4dannjjm 3093 14 surface surface NN cord-023095-4dannjjm 3093 15 associated associate VBN cord-023095-4dannjjm 3093 16 immunoglobulin immunoglobulin NN cord-023095-4dannjjm 3093 17 ( ( -LRB- cord-023095-4dannjjm 3093 18 pSAIG pSAIG NNP cord-023095-4dannjjm 3093 19 ) ) -RRB- cord-023095-4dannjjm 3093 20 and and CC cord-023095-4dannjjm 3093 21 staining stain VBG cord-023095-4dannjjm 3093 22 with with IN cord-023095-4dannjjm 3093 23 anti anti JJ cord-023095-4dannjjm 3093 24 - - JJ cord-023095-4dannjjm 3093 25 CD61 cd61 JJ cord-023095-4dannjjm 3093 26 antibodies antibody NNS cord-023095-4dannjjm 3093 27 ( ( -LRB- cord-023095-4dannjjm 3093 28 CD61ab CD61ab NNP cord-023095-4dannjjm 3093 29 ) ) -RRB- cord-023095-4dannjjm 3093 30 for for IN cord-023095-4dannjjm 3093 31 the the DT cord-023095-4dannjjm 3093 32 utilization utilization NN cord-023095-4dannjjm 3093 33 in in IN cord-023095-4dannjjm 3093 34 classifying classify VBG cord-023095-4dannjjm 3093 35 thrombocytopenic thrombocytopenic JJ cord-023095-4dannjjm 3093 36 dogs dog NNS cord-023095-4dannjjm 3093 37 . . . cord-023095-4dannjjm 3094 1 One one CD cord-023095-4dannjjm 3094 2 hundred hundred CD cord-023095-4dannjjm 3094 3 clinically clinically RB cord-023095-4dannjjm 3094 4 ill ill JJ cord-023095-4dannjjm 3094 5 and and CC cord-023095-4dannjjm 3094 6 30 30 CD cord-023095-4dannjjm 3095 1 apparently apparently RB cord-023095-4dannjjm 3095 2 healthy healthy JJ cord-023095-4dannjjm 3095 3 dogs dog NNS cord-023095-4dannjjm 3095 4 were be VBD cord-023095-4dannjjm 3095 5 prospectively prospectively RB cord-023095-4dannjjm 3095 6 evaluated evaluate VBN cord-023095-4dannjjm 3095 7 . . . cord-023095-4dannjjm 3096 1 Data datum NNS cord-023095-4dannjjm 3096 2 collected collect VBD cord-023095-4dannjjm 3096 3 included include VBD cord-023095-4dannjjm 3096 4 a a DT cord-023095-4dannjjm 3096 5 history history NN cord-023095-4dannjjm 3096 6 of of IN cord-023095-4dannjjm 3096 7 hemorrhage hemorrhage NN cord-023095-4dannjjm 3096 8 , , , cord-023095-4dannjjm 3096 9 physical physical JJ cord-023095-4dannjjm 3096 10 examination examination NN cord-023095-4dannjjm 3096 11 evidence evidence NN cord-023095-4dannjjm 3096 12 of of IN cord-023095-4dannjjm 3096 13 bleeding bleed VBG cord-023095-4dannjjm 3096 14 , , , cord-023095-4dannjjm 3096 15 complete complete JJ cord-023095-4dannjjm 3096 16 blood blood NN cord-023095-4dannjjm 3096 17 count count NN cord-023095-4dannjjm 3096 18 , , , cord-023095-4dannjjm 3096 19 and and CC cord-023095-4dannjjm 3096 20 measurement measurement NN cord-023095-4dannjjm 3096 21 of of IN cord-023095-4dannjjm 3096 22 pSAIG pSAIG NNP cord-023095-4dannjjm 3096 23 and and CC cord-023095-4dannjjm 3096 24 CD61ab CD61ab NNP cord-023095-4dannjjm 3096 25 . . . cord-023095-4dannjjm 3097 1 The the DT cord-023095-4dannjjm 3097 2 pSAIG pSAIG NNP cord-023095-4dannjjm 3097 3 assay assay NN cord-023095-4dannjjm 3097 4 utilized utilize VBN cord-023095-4dannjjm 3097 5 polyvalent polyvalent JJ cord-023095-4dannjjm 3097 6 antibodies antibody NNS cord-023095-4dannjjm 3097 7 with with IN cord-023095-4dannjjm 3097 8 correction correction NN cord-023095-4dannjjm 3097 9 for for IN cord-023095-4dannjjm 3097 10 non non JJ cord-023095-4dannjjm 3097 11 - - JJ cord-023095-4dannjjm 3097 12 specific specific JJ cord-023095-4dannjjm 3097 13 binding binding NN cord-023095-4dannjjm 3097 14 by by IN cord-023095-4dannjjm 3097 15 subtraction subtraction NN cord-023095-4dannjjm 3097 16 of of IN cord-023095-4dannjjm 3097 17 background background NN cord-023095-4dannjjm 3097 18 fluorescence fluorescence NN cord-023095-4dannjjm 3097 19 with with IN cord-023095-4dannjjm 3097 20 control control NN cord-023095-4dannjjm 3097 21 antiserum antiserum NN cord-023095-4dannjjm 3097 22 . . . cord-023095-4dannjjm 3098 1 Thrombocytopenia Thrombocytopenia NNP cord-023095-4dannjjm 3098 2 was be VBD cord-023095-4dannjjm 3098 3 defined define VBN cord-023095-4dannjjm 3098 4 as as IN cord-023095-4dannjjm 3098 5 o o CD cord-023095-4dannjjm 3098 6 164,000 164,000 CD cord-023095-4dannjjm 3098 7 / / SYM cord-023095-4dannjjm 3098 8 mL ml NN cord-023095-4dannjjm 3098 9 and and CC cord-023095-4dannjjm 3098 10 all all DT cord-023095-4dannjjm 3098 11 dogs dog NNS cord-023095-4dannjjm 3098 12 were be VBD cord-023095-4dannjjm 3098 13 clinically clinically RB cord-023095-4dannjjm 3098 14 classified classify VBN cord-023095-4dannjjm 3098 15 into into IN cord-023095-4dannjjm 3098 16 1 1 CD cord-023095-4dannjjm 3098 17 of of IN cord-023095-4dannjjm 3098 18 4 4 CD cord-023095-4dannjjm 3098 19 groups group NNS cord-023095-4dannjjm 3098 20 ( ( -LRB- cord-023095-4dannjjm 3098 21 g g NN cord-023095-4dannjjm 3098 22 ) ) -RRB- cord-023095-4dannjjm 3098 23 : : : cord-023095-4dannjjm 3099 1 g1 g1 NNP cord-023095-4dannjjm 3099 2 IMT IMT NNP cord-023095-4dannjjm 3099 3 , , , cord-023095-4dannjjm 3099 4 n n NN cord-023095-4dannjjm 3099 5 5 5 CD cord-023095-4dannjjm 3099 6 45 45 CD cord-023095-4dannjjm 3099 7 , , , cord-023095-4dannjjm 3099 8 g2 g2 NNP cord-023095-4dannjjm 3099 9 Thrombocytopenia Thrombocytopenia NNP cord-023095-4dannjjm 3099 10 from from IN cord-023095-4dannjjm 3099 11 non non JJ cord-023095-4dannjjm 3099 12 - - JJ cord-023095-4dannjjm 3099 13 immune immune JJ cord-023095-4dannjjm 3099 14 mediated mediate VBN cord-023095-4dannjjm 3099 15 diseases disease NNS cord-023095-4dannjjm 3099 16 , , , cord-023095-4dannjjm 3099 17 n n NN cord-023095-4dannjjm 3099 18 5 5 CD cord-023095-4dannjjm 3099 19 37 37 CD cord-023095-4dannjjm 3099 20 , , , cord-023095-4dannjjm 3100 1 g3 g3 NNP cord-023095-4dannjjm 3100 2 Ill Ill NNP cord-023095-4dannjjm 3100 3 with with IN cord-023095-4dannjjm 3100 4 normal normal JJ cord-023095-4dannjjm 3100 5 platelet platelet NN cord-023095-4dannjjm 3100 6 counts count NNS cord-023095-4dannjjm 3100 7 , , , cord-023095-4dannjjm 3100 8 n n NN cord-023095-4dannjjm 3100 9 5 5 CD cord-023095-4dannjjm 3100 10 18 18 CD cord-023095-4dannjjm 3100 11 , , , cord-023095-4dannjjm 3100 12 g4 g4 NNP cord-023095-4dannjjm 3100 13 Healthy Healthy NNP cord-023095-4dannjjm 3100 14 dogs dog NNS cord-023095-4dannjjm 3100 15 , , , cord-023095-4dannjjm 3100 16 n n NN cord-023095-4dannjjm 3100 17 5 5 CD cord-023095-4dannjjm 3100 18 30 30 CD cord-023095-4dannjjm 3100 19 . . . cord-023095-4dannjjm 3101 1 Median median JJ cord-023095-4dannjjm 3101 2 platelet platelet NN cord-023095-4dannjjm 3101 3 counts count NNS cord-023095-4dannjjm 3101 4 , , , cord-023095-4dannjjm 3101 5 by by IN cord-023095-4dannjjm 3101 6 groups group NNS cord-023095-4dannjjm 3101 7 , , , cord-023095-4dannjjm 3101 8 were be VBD cord-023095-4dannjjm 3101 9 g1 g1 NNP cord-023095-4dannjjm 3101 10 , , , cord-023095-4dannjjm 3101 11 20,000 20,000 CD cord-023095-4dannjjm 3101 12 ; ; : cord-023095-4dannjjm 3101 13 g2 g2 NNP cord-023095-4dannjjm 3101 14 , , , cord-023095-4dannjjm 3101 15 69,000 69,000 CD cord-023095-4dannjjm 3101 16 ; ; : cord-023095-4dannjjm 3101 17 g3 g3 NNP cord-023095-4dannjjm 3101 18 , , , cord-023095-4dannjjm 3101 19 324,500 324,500 CD cord-023095-4dannjjm 3101 20 ; ; : cord-023095-4dannjjm 3101 21 and and CC cord-023095-4dannjjm 3101 22 g4 g4 NNP cord-023095-4dannjjm 3101 23 , , , cord-023095-4dannjjm 3101 24 212,000 212,000 CD cord-023095-4dannjjm 3101 25 / / SYM cord-023095-4dannjjm 3101 26 mL. mL. NNS cord-023095-4dannjjm 3102 1 For for IN cord-023095-4dannjjm 3102 2 the the DT cord-023095-4dannjjm 3102 3 direct direct JJ cord-023095-4dannjjm 3102 4 and and CC cord-023095-4dannjjm 3102 5 indirect indirect JJ cord-023095-4dannjjm 3102 6 pSAIGs psaigs NN cord-023095-4dannjjm 3102 7 in in IN cord-023095-4dannjjm 3102 8 dogs dog NNS cord-023095-4dannjjm 3102 9 with with IN cord-023095-4dannjjm 3102 10 ITP ITP NNP cord-023095-4dannjjm 3102 11 ( ( -LRB- cord-023095-4dannjjm 3102 12 g1 g1 NNP cord-023095-4dannjjm 3102 13 ) ) -RRB- cord-023095-4dannjjm 3102 14 , , , cord-023095-4dannjjm 3102 15 more more JJR cord-023095-4dannjjm 3102 16 dogs dog NNS cord-023095-4dannjjm 3102 17 ( ( -LRB- cord-023095-4dannjjm 3102 18 n n NN cord-023095-4dannjjm 3102 19 5 5 CD cord-023095-4dannjjm 3102 20 6 6 CD cord-023095-4dannjjm 3102 21 and and CC cord-023095-4dannjjm 3102 22 n n NN cord-023095-4dannjjm 3102 23 5 5 CD cord-023095-4dannjjm 3102 24 9 9 CD cord-023095-4dannjjm 3102 25 ) ) -RRB- cord-023095-4dannjjm 3102 26 with with IN cord-023095-4dannjjm 3102 27 clinical clinical JJ cord-023095-4dannjjm 3102 28 evidence evidence NN cord-023095-4dannjjm 3102 29 of of IN cord-023095-4dannjjm 3102 30 bleeding bleed VBG cord-023095-4dannjjm 3102 31 had have VBD cord-023095-4dannjjm 3102 32 antibodies antibody NNS cord-023095-4dannjjm 3102 33 compared compare VBN cord-023095-4dannjjm 3102 34 to to IN cord-023095-4dannjjm 3102 35 those those DT cord-023095-4dannjjm 3102 36 who who WP cord-023095-4dannjjm 3102 37 were be VBD cord-023095-4dannjjm 3102 38 not not RB cord-023095-4dannjjm 3102 39 bleeding bleed VBG cord-023095-4dannjjm 3102 40 ( ( -LRB- cord-023095-4dannjjm 3102 41 n n NN cord-023095-4dannjjm 3102 42 5 5 CD cord-023095-4dannjjm 3102 43 3 3 CD cord-023095-4dannjjm 3102 44 and and CC cord-023095-4dannjjm 3102 45 n n NN cord-023095-4dannjjm 3102 46 5 5 CD cord-023095-4dannjjm 3102 47 6 6 CD cord-023095-4dannjjm 3102 48 ) ) -RRB- cord-023095-4dannjjm 3102 49 . . . cord-023095-4dannjjm 3103 1 Considering consider VBG cord-023095-4dannjjm 3103 2 only only RB cord-023095-4dannjjm 3103 3 direct direct VB cord-023095-4dannjjm 3103 4 pSAIG psaig XX cord-023095-4dannjjm 3103 5 the the DT cord-023095-4dannjjm 3103 6 sensitivity sensitivity NN cord-023095-4dannjjm 3103 7 and and CC cord-023095-4dannjjm 3103 8 specificity specificity NN cord-023095-4dannjjm 3103 9 was be VBD cord-023095-4dannjjm 3103 10 13 13 CD cord-023095-4dannjjm 3103 11 % % NN cord-023095-4dannjjm 3103 12 and and CC cord-023095-4dannjjm 3103 13 95 95 CD cord-023095-4dannjjm 3103 14 % % NN cord-023095-4dannjjm 3103 15 , , , cord-023095-4dannjjm 3103 16 respectively respectively RB cord-023095-4dannjjm 3103 17 for for IN cord-023095-4dannjjm 3103 18 the the DT cord-023095-4dannjjm 3103 19 diagnosis diagnosis NN cord-023095-4dannjjm 3103 20 of of IN cord-023095-4dannjjm 3103 21 IMT IMT NNP cord-023095-4dannjjm 3103 22 . . . cord-023095-4dannjjm 3104 1 For for IN cord-023095-4dannjjm 3104 2 indirect indirect JJ cord-023095-4dannjjm 3104 3 pSAIG psaig XX cord-023095-4dannjjm 3104 4 the the DT cord-023095-4dannjjm 3104 5 sensitivity sensitivity NN cord-023095-4dannjjm 3104 6 and and CC cord-023095-4dannjjm 3104 7 specificity specificity NN cord-023095-4dannjjm 3104 8 was be VBD cord-023095-4dannjjm 3104 9 27 27 CD cord-023095-4dannjjm 3104 10 % % NN cord-023095-4dannjjm 3104 11 and and CC cord-023095-4dannjjm 3104 12 97 97 CD cord-023095-4dannjjm 3104 13 % % NN cord-023095-4dannjjm 3104 14 , , , cord-023095-4dannjjm 3104 15 respectively respectively RB cord-023095-4dannjjm 3104 16 , , , cord-023095-4dannjjm 3104 17 for for IN cord-023095-4dannjjm 3104 18 the the DT cord-023095-4dannjjm 3104 19 diagnosis diagnosis NN cord-023095-4dannjjm 3104 20 of of IN cord-023095-4dannjjm 3104 21 IMT IMT NNP cord-023095-4dannjjm 3104 22 . . . cord-023095-4dannjjm 3105 1 When when WRB cord-023095-4dannjjm 3105 2 considering consider VBG cord-023095-4dannjjm 3105 3 both both CC cord-023095-4dannjjm 3105 4 direct direct JJ cord-023095-4dannjjm 3105 5 and and CC cord-023095-4dannjjm 3105 6 indirect indirect JJ cord-023095-4dannjjm 3105 7 pSAIG psaig XX cord-023095-4dannjjm 3106 1 together together RB cord-023095-4dannjjm 3106 2 , , , cord-023095-4dannjjm 3106 3 the the DT cord-023095-4dannjjm 3106 4 sensitivity sensitivity NN cord-023095-4dannjjm 3106 5 was be VBD cord-023095-4dannjjm 3106 6 33 33 CD cord-023095-4dannjjm 3106 7 % % NN cord-023095-4dannjjm 3106 8 with with IN cord-023095-4dannjjm 3106 9 a a DT cord-023095-4dannjjm 3106 10 specificity specificity NN cord-023095-4dannjjm 3106 11 of of IN cord-023095-4dannjjm 3106 12 93 93 CD cord-023095-4dannjjm 3106 13 % % NN cord-023095-4dannjjm 3106 14 . . . cord-023095-4dannjjm 3107 1 In in IN cord-023095-4dannjjm 3107 2 g1 g1 NNP cord-023095-4dannjjm 3107 3 interference interference NN cord-023095-4dannjjm 3107 4 from from IN cord-023095-4dannjjm 3107 5 high high JJ cord-023095-4dannjjm 3107 6 control control NN cord-023095-4dannjjm 3107 7 antiserum antiserum NN cord-023095-4dannjjm 3107 8 background background NN cord-023095-4dannjjm 3107 9 staining staining NN cord-023095-4dannjjm 3107 10 was be VBD cord-023095-4dannjjm 3107 11 noted note VBN cord-023095-4dannjjm 3107 12 in in IN cord-023095-4dannjjm 3107 13 26.7 26.7 CD cord-023095-4dannjjm 3107 14 % % NN cord-023095-4dannjjm 3107 15 of of IN cord-023095-4dannjjm 3107 16 dogs dog NNS cord-023095-4dannjjm 3107 17 and and CC cord-023095-4dannjjm 3107 18 resulted result VBD cord-023095-4dannjjm 3107 19 in in IN cord-023095-4dannjjm 3107 20 a a DT cord-023095-4dannjjm 3107 21 negative negative JJ cord-023095-4dannjjm 3107 22 direct direct JJ cord-023095-4dannjjm 3107 23 pSAIG psaig NN cord-023095-4dannjjm 3107 24 classification classification NN cord-023095-4dannjjm 3107 25 . . . cord-023095-4dannjjm 3108 1 Minimal minimal JJ cord-023095-4dannjjm 3108 2 background background NN cord-023095-4dannjjm 3108 3 interference interference NN cord-023095-4dannjjm 3108 4 was be VBD cord-023095-4dannjjm 3108 5 noted note VBN cord-023095-4dannjjm 3108 6 in in IN cord-023095-4dannjjm 3108 7 g2 g2 NNP cord-023095-4dannjjm 3108 8 , , , cord-023095-4dannjjm 3108 9 g3 g3 NNP cord-023095-4dannjjm 3108 10 , , , cord-023095-4dannjjm 3108 11 or or CC cord-023095-4dannjjm 3108 12 g4 g4 NNP cord-023095-4dannjjm 3108 13 . . . cord-023095-4dannjjm 3109 1 The the DT cord-023095-4dannjjm 3109 2 percentage percentage NN cord-023095-4dannjjm 3109 3 of of IN cord-023095-4dannjjm 3109 4 platelets platelet NNS cord-023095-4dannjjm 3109 5 stained stain VBN cord-023095-4dannjjm 3109 6 with with IN cord-023095-4dannjjm 3109 7 CD61ab CD61ab NNP cord-023095-4dannjjm 3109 8 was be VBD cord-023095-4dannjjm 3109 9 significantly significantly RB cord-023095-4dannjjm 3109 10 less less JJR cord-023095-4dannjjm 3109 11 in in IN cord-023095-4dannjjm 3109 12 g1 g1 NNP cord-023095-4dannjjm 3109 13 ( ( -LRB- cord-023095-4dannjjm 3109 14 median median NN cord-023095-4dannjjm 3109 15 38 38 CD cord-023095-4dannjjm 3109 16 , , , cord-023095-4dannjjm 3109 17 p p NN cord-023095-4dannjjm 3109 18 5 5 CD cord-023095-4dannjjm 3109 19 0.0001 0.0001 CD cord-023095-4dannjjm 3109 20 ) ) -RRB- cord-023095-4dannjjm 3109 21 vs. vs. IN cord-023095-4dannjjm 3109 22 g2 g2 NNP cord-023095-4dannjjm 3109 23 ( ( -LRB- cord-023095-4dannjjm 3109 24 median median NN cord-023095-4dannjjm 3109 25 74 74 CD cord-023095-4dannjjm 3109 26 , , , cord-023095-4dannjjm 3109 27 p p NN cord-023095-4dannjjm 3109 28 5 5 CD cord-023095-4dannjjm 3109 29 0.007 0.007 CD cord-023095-4dannjjm 3109 30 ) ) -RRB- cord-023095-4dannjjm 3109 31 vs. vs. IN cord-023095-4dannjjm 3109 32 g3 g3 NNP cord-023095-4dannjjm 3109 33 ( ( -LRB- cord-023095-4dannjjm 3109 34 median median NN cord-023095-4dannjjm 3109 35 95.1 95.1 CD cord-023095-4dannjjm 3109 36 , , , cord-023095-4dannjjm 3109 37 p p NN cord-023095-4dannjjm 3109 38 5 5 CD cord-023095-4dannjjm 3109 39 0.857 0.857 CD cord-023095-4dannjjm 3109 40 ) ) -RRB- cord-023095-4dannjjm 3109 41 and and CC cord-023095-4dannjjm 3109 42 g4 g4 NNP cord-023095-4dannjjm 3109 43 ( ( -LRB- cord-023095-4dannjjm 3109 44 median median JJ cord-023095-4dannjjm 3109 45 95.6 95.6 CD cord-023095-4dannjjm 3109 46 ) ) -RRB- cord-023095-4dannjjm 3109 47 . . . cord-023095-4dannjjm 3110 1 These these DT cord-023095-4dannjjm 3110 2 findings finding NNS cord-023095-4dannjjm 3110 3 indicate indicate VBP cord-023095-4dannjjm 3110 4 the the DT cord-023095-4dannjjm 3110 5 optimized optimize VBN cord-023095-4dannjjm 3110 6 platelet platelet NN cord-023095-4dannjjm 3110 7 surface surface NN cord-023095-4dannjjm 3110 8 associated associate VBN cord-023095-4dannjjm 3110 9 immunoglobulin immunoglobulin NN cord-023095-4dannjjm 3110 10 assay assay NN cord-023095-4dannjjm 3110 11 has have VBZ cord-023095-4dannjjm 3110 12 a a DT cord-023095-4dannjjm 3110 13 high high JJ cord-023095-4dannjjm 3110 14 specificity specificity NN cord-023095-4dannjjm 3110 15 , , , cord-023095-4dannjjm 3110 16 however however RB cord-023095-4dannjjm 3110 17 poor poor JJ cord-023095-4dannjjm 3110 18 sensitivity sensitivity NN cord-023095-4dannjjm 3110 19 , , , cord-023095-4dannjjm 3110 20 for for IN cord-023095-4dannjjm 3110 21 the the DT cord-023095-4dannjjm 3110 22 diagnosis diagnosis NN cord-023095-4dannjjm 3110 23 of of IN cord-023095-4dannjjm 3110 24 IMT IMT NNP cord-023095-4dannjjm 3110 25 . . . cord-023095-4dannjjm 3111 1 The the DT cord-023095-4dannjjm 3111 2 decreased decrease VBN cord-023095-4dannjjm 3111 3 CD61 CD61 NNP cord-023095-4dannjjm 3111 4 staining stain VBG cord-023095-4dannjjm 3111 5 in in IN cord-023095-4dannjjm 3111 6 g1 g1 NNP cord-023095-4dannjjm 3111 7 ( ( -LRB- cord-023095-4dannjjm 3111 8 IMT IMT NNP cord-023095-4dannjjm 3111 9 group group NN cord-023095-4dannjjm 3111 10 ) ) -RRB- cord-023095-4dannjjm 3111 11 may may MD cord-023095-4dannjjm 3111 12 reflect reflect VB cord-023095-4dannjjm 3111 13 decreased decrease VBN cord-023095-4dannjjm 3111 14 surface surface NN cord-023095-4dannjjm 3111 15 gpIIIa gpiiia JJ cord-023095-4dannjjm 3111 16 expression expression NN cord-023095-4dannjjm 3111 17 , , , cord-023095-4dannjjm 3111 18 blocking block VBG cord-023095-4dannjjm 3111 19 by by IN cord-023095-4dannjjm 3111 20 anti anti JJ cord-023095-4dannjjm 3111 21 - - JJ cord-023095-4dannjjm 3111 22 gpIIIa gpiiia JJ cord-023095-4dannjjm 3111 23 antibodies antibody NNS cord-023095-4dannjjm 3111 24 or or CC cord-023095-4dannjjm 3111 25 other other JJ cord-023095-4dannjjm 3111 26 proteins protein NNS cord-023095-4dannjjm 3111 27 , , , cord-023095-4dannjjm 3111 28 clearance clearance NN cord-023095-4dannjjm 3111 29 by by IN cord-023095-4dannjjm 3111 30 macrophages macrophage NNS cord-023095-4dannjjm 3111 31 , , , cord-023095-4dannjjm 3111 32 or or CC cord-023095-4dannjjm 3111 33 increased increase VBN cord-023095-4dannjjm 3111 34 non non JJ cord-023095-4dannjjm 3111 35 - - JJ cord-023095-4dannjjm 3111 36 platelet platelet JJ cord-023095-4dannjjm 3111 37 debris debris NN cord-023095-4dannjjm 3111 38 and and CC cord-023095-4dannjjm 3111 39 has have VBZ cord-023095-4dannjjm 3111 40 potential potential JJ cord-023095-4dannjjm 3111 41 applications application NNS cord-023095-4dannjjm 3111 42 in in IN cord-023095-4dannjjm 3111 43 the the DT cord-023095-4dannjjm 3111 44 diagnosis diagnosis NN cord-023095-4dannjjm 3111 45 and and CC cord-023095-4dannjjm 3111 46 treatment treatment NN cord-023095-4dannjjm 3111 47 of of IN cord-023095-4dannjjm 3111 48 IMT IMT NNP cord-023095-4dannjjm 3111 49 . . . cord-023095-4dannjjm 3112 1 Greyhounds greyhound NNS cord-023095-4dannjjm 3112 2 have have VBP cord-023095-4dannjjm 3112 3 lower low JJR cord-023095-4dannjjm 3112 4 serum serum NN cord-023095-4dannjjm 3112 5 concentrations concentration NNS cord-023095-4dannjjm 3112 6 of of IN cord-023095-4dannjjm 3112 7 a a DT cord-023095-4dannjjm 3112 8 - - HYPH cord-023095-4dannjjm 3112 9 globulin globulin NN cord-023095-4dannjjm 3112 10 than than IN cord-023095-4dannjjm 3112 11 other other JJ cord-023095-4dannjjm 3112 12 breeds breed NNS cord-023095-4dannjjm 3112 13 , , , cord-023095-4dannjjm 3112 14 explained explain VBN cord-023095-4dannjjm 3112 15 by by IN cord-023095-4dannjjm 3112 16 negligible negligible JJ cord-023095-4dannjjm 3112 17 levels level NNS cord-023095-4dannjjm 3112 18 of of IN cord-023095-4dannjjm 3112 19 haptoglobin haptoglobin NN cord-023095-4dannjjm 3112 20 ( ( -LRB- cord-023095-4dannjjm 3112 21 HP HP NNP cord-023095-4dannjjm 3112 22 ) ) -RRB- cord-023095-4dannjjm 3112 23 measured measure VBD cord-023095-4dannjjm 3112 24 using use VBG cord-023095-4dannjjm 3112 25 different different JJ cord-023095-4dannjjm 3112 26 methods method NNS cord-023095-4dannjjm 3112 27 ( ( -LRB- cord-023095-4dannjjm 3112 28 colorimetric colorimetric JJ cord-023095-4dannjjm 3112 29 , , , cord-023095-4dannjjm 3112 30 immunoturbidimetric immunoturbidimetric JJ cord-023095-4dannjjm 3112 31 and and CC cord-023095-4dannjjm 3112 32 protein protein NN cord-023095-4dannjjm 3112 33 electrophoresis electrophoresis NN cord-023095-4dannjjm 3112 34 ) ) -RRB- cord-023095-4dannjjm 3112 35 . . . cord-023095-4dannjjm 3113 1 The the DT cord-023095-4dannjjm 3113 2 purpose purpose NN cord-023095-4dannjjm 3113 3 of of IN cord-023095-4dannjjm 3113 4 the the DT cord-023095-4dannjjm 3113 5 present present JJ cord-023095-4dannjjm 3113 6 study study NN cord-023095-4dannjjm 3113 7 was be VBD cord-023095-4dannjjm 3113 8 to to TO cord-023095-4dannjjm 3113 9 characterize characterize VB cord-023095-4dannjjm 3113 10 the the DT cord-023095-4dannjjm 3113 11 HP HP NNP cord-023095-4dannjjm 3113 12 gene gene NN cord-023095-4dannjjm 3113 13 in in IN cord-023095-4dannjjm 3113 14 Greyhounds greyhound NNS cord-023095-4dannjjm 3113 15 . . . cord-023095-4dannjjm 3114 1 We -PRON- PRP cord-023095-4dannjjm 3114 2 isolated isolate VBD cord-023095-4dannjjm 3114 3 DNA DNA NNP cord-023095-4dannjjm 3114 4 and and CC cord-023095-4dannjjm 3114 5 RNA RNA NNP cord-023095-4dannjjm 3114 6 from from IN cord-023095-4dannjjm 3114 7 blood blood NN cord-023095-4dannjjm 3114 8 samples sample NNS cord-023095-4dannjjm 3114 9 of of IN cord-023095-4dannjjm 3114 10 AKC AKC NNP cord-023095-4dannjjm 3114 11 - - HYPH cord-023095-4dannjjm 3114 12 registered register VBN cord-023095-4dannjjm 3114 13 and and CC cord-023095-4dannjjm 3114 14 retired retired JJ cord-023095-4dannjjm 3114 15 racing racing NN cord-023095-4dannjjm 3114 16 Greyhounds greyhound NNS cord-023095-4dannjjm 3114 17 ( ( -LRB- cord-023095-4dannjjm 3114 18 AKCG AKCG NNP cord-023095-4dannjjm 3114 19 , , , cord-023095-4dannjjm 3114 20 RRG RRG NNP cord-023095-4dannjjm 3114 21 ) ) -RRB- cord-023095-4dannjjm 3114 22 , , , cord-023095-4dannjjm 3114 23 and and CC cord-023095-4dannjjm 3114 24 a a DT cord-023095-4dannjjm 3114 25 German german JJ cord-023095-4dannjjm 3114 26 Shepherd Shepherd NNP cord-023095-4dannjjm 3114 27 Dog Dog NNP cord-023095-4dannjjm 3114 28 ( ( -LRB- cord-023095-4dannjjm 3114 29 GSD GSD NNP cord-023095-4dannjjm 3114 30 ) ) -RRB- cord-023095-4dannjjm 3114 31 . . . cord-023095-4dannjjm 3115 1 We -PRON- PRP cord-023095-4dannjjm 3115 2 sequenced sequence VBD cord-023095-4dannjjm 3115 3 the the DT cord-023095-4dannjjm 3115 4 HP HP NNP cord-023095-4dannjjm 3115 5 exons exon NNS cord-023095-4dannjjm 3115 6 and and CC cord-023095-4dannjjm 3115 7 splice splice NN cord-023095-4dannjjm 3115 8 sites site NNS cord-023095-4dannjjm 3115 9 , , , cord-023095-4dannjjm 3115 10 and and CC cord-023095-4dannjjm 3115 11 conducted conduct VBN cord-023095-4dannjjm 3115 12 array array NN cord-023095-4dannjjm 3115 13 comparative comparative JJ cord-023095-4dannjjm 3115 14 genomic genomic JJ cord-023095-4dannjjm 3115 15 hybridization hybridization NN cord-023095-4dannjjm 3115 16 to to TO cord-023095-4dannjjm 3115 17 identify identify VB cord-023095-4dannjjm 3115 18 associated associate VBN cord-023095-4dannjjm 3115 19 DNA dna NN cord-023095-4dannjjm 3115 20 structural structural JJ cord-023095-4dannjjm 3115 21 variation variation NN cord-023095-4dannjjm 3115 22 ( ( -LRB- cord-023095-4dannjjm 3115 23 custom custom NN cord-023095-4dannjjm 3115 24 1 1 CD cord-023095-4dannjjm 3115 25 M M NNP cord-023095-4dannjjm 3115 26 Agilent Agilent NNP cord-023095-4dannjjm 3115 27 oligonucleotide oligonucleotide JJ cord-023095-4dannjjm 3115 28 array array NN cord-023095-4dannjjm 3115 29 ) ) -RRB- cord-023095-4dannjjm 3115 30 . . . cord-023095-4dannjjm 3116 1 Additionally additionally RB cord-023095-4dannjjm 3116 2 , , , cord-023095-4dannjjm 3116 3 we -PRON- PRP cord-023095-4dannjjm 3116 4 tested test VBD cord-023095-4dannjjm 3116 5 for for IN cord-023095-4dannjjm 3116 6 the the DT cord-023095-4dannjjm 3116 7 presence presence NN cord-023095-4dannjjm 3116 8 of of IN cord-023095-4dannjjm 3116 9 one one CD cord-023095-4dannjjm 3116 10 or or CC cord-023095-4dannjjm 3116 11 multiple multiple JJ cord-023095-4dannjjm 3116 12 haplotypes haplotype NNS cord-023095-4dannjjm 3116 13 spanning span VBG cord-023095-4dannjjm 3116 14 HP HP NNP cord-023095-4dannjjm 3116 15 in in IN cord-023095-4dannjjm 3116 16 Greyhounds greyhound NNS cord-023095-4dannjjm 3116 17 using use VBG cord-023095-4dannjjm 3116 18 a a DT cord-023095-4dannjjm 3116 19 high high JJ cord-023095-4dannjjm 3116 20 density density NN cord-023095-4dannjjm 3116 21 SNP SNP NNP cord-023095-4dannjjm 3116 22 array array NN cord-023095-4dannjjm 3116 23 ( ( -LRB- cord-023095-4dannjjm 3116 24 180k 180k CD cord-023095-4dannjjm 3116 25 Illumina Illumina NNP cord-023095-4dannjjm 3116 26 HD HD NNP cord-023095-4dannjjm 3116 27 ) ) -RRB- cord-023095-4dannjjm 3116 28 . . . cord-023095-4dannjjm 3117 1 Sequencing sequencing NN cord-023095-4dannjjm 3117 2 results result NNS cord-023095-4dannjjm 3117 3 of of IN cord-023095-4dannjjm 3117 4 HP HP NNP cord-023095-4dannjjm 3117 5 in in IN cord-023095-4dannjjm 3117 6 both both CC cord-023095-4dannjjm 3117 7 DNA DNA NNP cord-023095-4dannjjm 3117 8 and and CC cord-023095-4dannjjm 3117 9 cDNA cdna NN cord-023095-4dannjjm 3117 10 revealed reveal VBD cord-023095-4dannjjm 3117 11 three three CD cord-023095-4dannjjm 3117 12 synonymous synonymous JJ cord-023095-4dannjjm 3117 13 SNPs snp NNS cord-023095-4dannjjm 3117 14 in in IN cord-023095-4dannjjm 3117 15 the the DT cord-023095-4dannjjm 3117 16 racing race VBG cord-023095-4dannjjm 3117 17 Greyhound Greyhound NNP cord-023095-4dannjjm 3117 18 . . . cord-023095-4dannjjm 3118 1 We -PRON- PRP cord-023095-4dannjjm 3118 2 did do VBD cord-023095-4dannjjm 3118 3 not not RB cord-023095-4dannjjm 3118 4 identify identify VB cord-023095-4dannjjm 3118 5 structural structural JJ cord-023095-4dannjjm 3118 6 variation variation NN cord-023095-4dannjjm 3118 7 overlapping overlap VBG cord-023095-4dannjjm 3118 8 or or CC cord-023095-4dannjjm 3118 9 near near IN cord-023095-4dannjjm 3118 10 the the DT cord-023095-4dannjjm 3118 11 HP HP NNP cord-023095-4dannjjm 3118 12 gene gene NN cord-023095-4dannjjm 3118 13 . . . cord-023095-4dannjjm 3119 1 Notably notably RB cord-023095-4dannjjm 3119 2 , , , cord-023095-4dannjjm 3119 3 we -PRON- PRP cord-023095-4dannjjm 3119 4 detected detect VBD cord-023095-4dannjjm 3119 5 that that IN cord-023095-4dannjjm 3119 6 the the DT cord-023095-4dannjjm 3119 7 RRG RRG NNP cord-023095-4dannjjm 3119 8 and and CC cord-023095-4dannjjm 3119 9 AKCG AKCG NNP cord-023095-4dannjjm 3119 10 do do VBP cord-023095-4dannjjm 3119 11 not not RB cord-023095-4dannjjm 3119 12 appear appear VB cord-023095-4dannjjm 3119 13 to to TO cord-023095-4dannjjm 3119 14 share share VB cord-023095-4dannjjm 3119 15 a a DT cord-023095-4dannjjm 3119 16 specific specific JJ cord-023095-4dannjjm 3119 17 haplotype haplotype NN cord-023095-4dannjjm 3119 18 spanning span VBG cord-023095-4dannjjm 3119 19 HP HP NNP cord-023095-4dannjjm 3119 20 . . . cord-023095-4dannjjm 3120 1 Despite despite IN cord-023095-4dannjjm 3120 2 having have VBG cord-023095-4dannjjm 3120 3 low low JJ cord-023095-4dannjjm 3120 4 or or CC cord-023095-4dannjjm 3120 5 undetectable undetectable JJ cord-023095-4dannjjm 3120 6 serum serum NN cord-023095-4dannjjm 3120 7 concentrations concentration NNS cord-023095-4dannjjm 3120 8 of of IN cord-023095-4dannjjm 3120 9 HP HP NNP cord-023095-4dannjjm 3120 10 , , , cord-023095-4dannjjm 3120 11 we -PRON- PRP cord-023095-4dannjjm 3120 12 did do VBD cord-023095-4dannjjm 3120 13 find find VB cord-023095-4dannjjm 3120 14 that that IN cord-023095-4dannjjm 3120 15 RRG RRG NNP cord-023095-4dannjjm 3120 16 HP HP NNP cord-023095-4dannjjm 3120 17 mRNA mrna NN cord-023095-4dannjjm 3120 18 is be VBZ cord-023095-4dannjjm 3120 19 expressed express VBN cord-023095-4dannjjm 3120 20 and and CC cord-023095-4dannjjm 3120 21 lacks lack VBZ cord-023095-4dannjjm 3120 22 amino amino JJ cord-023095-4dannjjm 3120 23 acid acid NN cord-023095-4dannjjm 3120 24 variation variation NN cord-023095-4dannjjm 3120 25 . . . cord-023095-4dannjjm 3121 1 This this DT cord-023095-4dannjjm 3121 2 suggests suggest VBZ cord-023095-4dannjjm 3121 3 that that IN cord-023095-4dannjjm 3121 4 the the DT cord-023095-4dannjjm 3121 5 clinical clinical JJ cord-023095-4dannjjm 3121 6 absence absence NN cord-023095-4dannjjm 3121 7 of of IN cord-023095-4dannjjm 3121 8 the the DT cord-023095-4dannjjm 3121 9 HP HP NNP cord-023095-4dannjjm 3121 10 is be VBZ cord-023095-4dannjjm 3121 11 attributable attributable JJ cord-023095-4dannjjm 3121 12 to to IN cord-023095-4dannjjm 3121 13 post post JJ cord-023095-4dannjjm 3121 14 - - JJ cord-023095-4dannjjm 3121 15 transcriptional transcriptional JJ cord-023095-4dannjjm 3121 16 HP HP NNP cord-023095-4dannjjm 3121 17 effects effect NNS cord-023095-4dannjjm 3121 18 or or CC cord-023095-4dannjjm 3121 19 to to IN cord-023095-4dannjjm 3121 20 an an DT cord-023095-4dannjjm 3121 21 unknown unknown JJ cord-023095-4dannjjm 3121 22 physiological physiological JJ cord-023095-4dannjjm 3121 23 interaction interaction NN cord-023095-4dannjjm 3121 24 . . . cord-023095-4dannjjm 3122 1 Finally finally RB cord-023095-4dannjjm 3122 2 , , , cord-023095-4dannjjm 3122 3 given give VBN cord-023095-4dannjjm 3122 4 the the DT cord-023095-4dannjjm 3122 5 existence existence NN cord-023095-4dannjjm 3122 6 of of IN cord-023095-4dannjjm 3122 7 distinct distinct JJ cord-023095-4dannjjm 3122 8 RRG RRG NNP cord-023095-4dannjjm 3122 9 and and CC cord-023095-4dannjjm 3122 10 AKCG AKCG NNP cord-023095-4dannjjm 3122 11 haplotypes haplotype NNS cord-023095-4dannjjm 3122 12 spanning span VBG cord-023095-4dannjjm 3122 13 HP HP NNP cord-023095-4dannjjm 3122 14 , , , cord-023095-4dannjjm 3122 15 it -PRON- PRP cord-023095-4dannjjm 3122 16 is be VBZ cord-023095-4dannjjm 3122 17 important important JJ cord-023095-4dannjjm 3122 18 to to TO cord-023095-4dannjjm 3122 19 characterize characterize VB cord-023095-4dannjjm 3122 20 serum serum NN cord-023095-4dannjjm 3122 21 levels level NNS cord-023095-4dannjjm 3122 22 of of IN cord-023095-4dannjjm 3122 23 HP HP NNP cord-023095-4dannjjm 3122 24 in in IN cord-023095-4dannjjm 3122 25 AKCG AKCG NNP cord-023095-4dannjjm 3122 26 in in IN cord-023095-4dannjjm 3122 27 follow follow NN cord-023095-4dannjjm 3122 28 on on IN cord-023095-4dannjjm 3122 29 studies study NNS cord-023095-4dannjjm 3122 30 . . . cord-023095-4dannjjm 3123 1 We -PRON- PRP cord-023095-4dannjjm 3123 2 reported report VBD cord-023095-4dannjjm 3123 3 that that DT cord-023095-4dannjjm 3123 4 hemoglobin hemoglobin NN cord-023095-4dannjjm 3123 5 in in IN cord-023095-4dannjjm 3123 6 retired retired JJ cord-023095-4dannjjm 3123 7 racing racing NN cord-023095-4dannjjm 3123 8 Greyhounds greyhound NNS cord-023095-4dannjjm 3123 9 ( ( -LRB- cord-023095-4dannjjm 3123 10 RRG RRG NNP cord-023095-4dannjjm 3123 11 ) ) -RRB- cord-023095-4dannjjm 3123 12 has have VBZ cord-023095-4dannjjm 3123 13 higher high JJR cord-023095-4dannjjm 3123 14 oxygen oxygen NN cord-023095-4dannjjm 3123 15 carrying carry VBG cord-023095-4dannjjm 3123 16 properties property NNS cord-023095-4dannjjm 3123 17 and and CC cord-023095-4dannjjm 3123 18 affinity affinity NN cord-023095-4dannjjm 3123 19 than than IN cord-023095-4dannjjm 3123 20 other other JJ cord-023095-4dannjjm 3123 21 breeds breed NNS cord-023095-4dannjjm 3123 22 . . . cord-023095-4dannjjm 3124 1 Surprisingly surprisingly RB cord-023095-4dannjjm 3124 2 , , , cord-023095-4dannjjm 3124 3 very very RB cord-023095-4dannjjm 3124 4 little little JJ cord-023095-4dannjjm 3124 5 is be VBZ cord-023095-4dannjjm 3124 6 known know VBN cord-023095-4dannjjm 3124 7 about about IN cord-023095-4dannjjm 3124 8 canine canine JJ cord-023095-4dannjjm 3124 9 hemoglobin hemoglobin NN cord-023095-4dannjjm 3124 10 genetics genetic NNS cord-023095-4dannjjm 3124 11 . . . cord-023095-4dannjjm 3125 1 The the DT cord-023095-4dannjjm 3125 2 purpose purpose NN cord-023095-4dannjjm 3125 3 of of IN cord-023095-4dannjjm 3125 4 this this DT cord-023095-4dannjjm 3125 5 study study NN cord-023095-4dannjjm 3125 6 was be VBD cord-023095-4dannjjm 3125 7 to to TO cord-023095-4dannjjm 3125 8 characterize characterize VB cord-023095-4dannjjm 3125 9 genetics genetic NNS cord-023095-4dannjjm 3125 10 of of IN cord-023095-4dannjjm 3125 11 canine canine JJ cord-023095-4dannjjm 3125 12 beta beta NN cord-023095-4dannjjm 3125 13 globins globin NNS cord-023095-4dannjjm 3125 14 . . . cord-023095-4dannjjm 3126 1 Using use VBG cord-023095-4dannjjm 3126 2 computational computational JJ cord-023095-4dannjjm 3126 3 BLAST blast NN cord-023095-4dannjjm 3126 4 analysis analysis NN cord-023095-4dannjjm 3126 5 of of IN cord-023095-4dannjjm 3126 6 the the DT cord-023095-4dannjjm 3126 7 dog dog NN cord-023095-4dannjjm 3126 8 genome genome NN cord-023095-4dannjjm 3126 9 , , , cord-023095-4dannjjm 3126 10 we -PRON- PRP cord-023095-4dannjjm 3126 11 identified identify VBD cord-023095-4dannjjm 3126 12 five five CD cord-023095-4dannjjm 3126 13 beta beta NN cord-023095-4dannjjm 3126 14 globin globin NN cord-023095-4dannjjm 3126 15 genes gene NNS cord-023095-4dannjjm 3126 16 in in IN cord-023095-4dannjjm 3126 17 a a DT cord-023095-4dannjjm 3126 18 single single JJ cord-023095-4dannjjm 3126 19 locus locus NN cord-023095-4dannjjm 3126 20 : : : cord-023095-4dannjjm 3126 21 two two CD cord-023095-4dannjjm 3126 22 human human JJ cord-023095-4dannjjm 3126 23 HBElike hbelike NN cord-023095-4dannjjm 3126 24 followed follow VBN cord-023095-4dannjjm 3126 25 by by IN cord-023095-4dannjjm 3126 26 three three CD cord-023095-4dannjjm 3126 27 HBB HBB NNP cord-023095-4dannjjm 3126 28 - - HYPH cord-023095-4dannjjm 3126 29 like like JJ cord-023095-4dannjjm 3126 30 genes gene NNS cord-023095-4dannjjm 3126 31 . . . cord-023095-4dannjjm 3127 1 We -PRON- PRP cord-023095-4dannjjm 3127 2 isolated isolate VBD cord-023095-4dannjjm 3127 3 DNA DNA NNP cord-023095-4dannjjm 3127 4 and and CC cord-023095-4dannjjm 3127 5 RNA RNA NNP cord-023095-4dannjjm 3127 6 from from IN cord-023095-4dannjjm 3127 7 blood blood NN cord-023095-4dannjjm 3127 8 of of IN cord-023095-4dannjjm 3127 9 RRGs rrg NNS cord-023095-4dannjjm 3127 10 , , , cord-023095-4dannjjm 3127 11 AKC AKC NNP cord-023095-4dannjjm 3127 12 registered register VBN cord-023095-4dannjjm 3127 13 Greyhounds greyhound NNS cord-023095-4dannjjm 3127 14 ( ( -LRB- cord-023095-4dannjjm 3127 15 AKCG AKCG NNP cord-023095-4dannjjm 3127 16 ) ) -RRB- cord-023095-4dannjjm 3127 17 , , , cord-023095-4dannjjm 3127 18 and and CC cord-023095-4dannjjm 3127 19 German german JJ cord-023095-4dannjjm 3127 20 Shepherd Shepherd NNP cord-023095-4dannjjm 3127 21 Dog Dog NNP cord-023095-4dannjjm 3127 22 ( ( -LRB- cord-023095-4dannjjm 3127 23 GSD GSD NNP cord-023095-4dannjjm 3127 24 ) ) -RRB- cord-023095-4dannjjm 3127 25 . . . cord-023095-4dannjjm 3128 1 All all DT cord-023095-4dannjjm 3128 2 beta beta NN cord-023095-4dannjjm 3128 3 globin globin NN cord-023095-4dannjjm 3128 4 exons exon NNS cord-023095-4dannjjm 3128 5 and and CC cord-023095-4dannjjm 3128 6 splice splice NN cord-023095-4dannjjm 3128 7 sites site NNS cord-023095-4dannjjm 3128 8 were be VBD cord-023095-4dannjjm 3128 9 sequenced sequence VBN cord-023095-4dannjjm 3128 10 , , , cord-023095-4dannjjm 3128 11 and and CC cord-023095-4dannjjm 3128 12 the the DT cord-023095-4dannjjm 3128 13 beta beta JJ cord-023095-4dannjjm 3128 14 globin globin NN cord-023095-4dannjjm 3128 15 locus locus NN cord-023095-4dannjjm 3128 16 was be VBD cord-023095-4dannjjm 3128 17 examined examine VBN cord-023095-4dannjjm 3128 18 by by IN cord-023095-4dannjjm 3128 19 array array NN cord-023095-4dannjjm 3128 20 comparative comparative JJ cord-023095-4dannjjm 3128 21 genomic genomic JJ cord-023095-4dannjjm 3128 22 hybridization hybridization NN cord-023095-4dannjjm 3128 23 ( ( -LRB- cord-023095-4dannjjm 3128 24 custom custom NN cord-023095-4dannjjm 3128 25 1 1 CD cord-023095-4dannjjm 3128 26 M M NNP cord-023095-4dannjjm 3128 27 Agilent Agilent NNP cord-023095-4dannjjm 3128 28 array array NN cord-023095-4dannjjm 3128 29 ) ) -RRB- cord-023095-4dannjjm 3128 30 . . . cord-023095-4dannjjm 3129 1 Additionally additionally RB cord-023095-4dannjjm 3129 2 , , , cord-023095-4dannjjm 3129 3 we -PRON- PRP cord-023095-4dannjjm 3129 4 determined determine VBD cord-023095-4dannjjm 3129 5 the the DT cord-023095-4dannjjm 3129 6 number number NN cord-023095-4dannjjm 3129 7 of of IN cord-023095-4dannjjm 3129 8 common common JJ cord-023095-4dannjjm 3129 9 haplotypes haplotype NNS cord-023095-4dannjjm 3129 10 that that WDT cord-023095-4dannjjm 3129 11 span span VBP cord-023095-4dannjjm 3129 12 this this DT cord-023095-4dannjjm 3129 13 locus locus NN cord-023095-4dannjjm 3129 14 in in IN cord-023095-4dannjjm 3129 15 RRGs rrg NNS cord-023095-4dannjjm 3129 16 and and CC cord-023095-4dannjjm 3129 17 AKCGs akcg NNS cord-023095-4dannjjm 3129 18 using use VBG cord-023095-4dannjjm 3129 19 high high JJ cord-023095-4dannjjm 3129 20 density density NN cord-023095-4dannjjm 3129 21 SNP SNP NNP cord-023095-4dannjjm 3129 22 array array NN cord-023095-4dannjjm 3129 23 ( ( -LRB- cord-023095-4dannjjm 3129 24 180k 180k CD cord-023095-4dannjjm 3129 25 Illumina Illumina NNP cord-023095-4dannjjm 3129 26 HD HD NNP cord-023095-4dannjjm 3129 27 ) ) -RRB- cord-023095-4dannjjm 3129 28 . . . cord-023095-4dannjjm 3130 1 Expression expression NN cord-023095-4dannjjm 3130 2 and and CC cord-023095-4dannjjm 3130 3 sequence sequence NN cord-023095-4dannjjm 3130 4 analysis analysis NN cord-023095-4dannjjm 3130 5 of of IN cord-023095-4dannjjm 3130 6 cDNA cdna NN cord-023095-4dannjjm 3130 7 showed show VBD cord-023095-4dannjjm 3130 8 all all DT cord-023095-4dannjjm 3130 9 five five CD cord-023095-4dannjjm 3130 10 beta beta JJ cord-023095-4dannjjm 3130 11 globin globin NN cord-023095-4dannjjm 3130 12 genes gene NNS cord-023095-4dannjjm 3130 13 are be VBP cord-023095-4dannjjm 3130 14 actively actively RB cord-023095-4dannjjm 3130 15 expressed express VBN cord-023095-4dannjjm 3130 16 in in IN cord-023095-4dannjjm 3130 17 adults adult NNS cord-023095-4dannjjm 3130 18 . . . cord-023095-4dannjjm 3131 1 CanHBB1 CanHBB1 NNP cord-023095-4dannjjm 3131 2 and and CC cord-023095-4dannjjm 3131 3 2 2 CD cord-023095-4dannjjm 3131 4 were be VBD cord-023095-4dannjjm 3131 5 created create VBN cord-023095-4dannjjm 3131 6 by by IN cord-023095-4dannjjm 3131 7 relatively relatively RB cord-023095-4dannjjm 3131 8 recent recent JJ cord-023095-4dannjjm 3131 9 segmental segmental JJ cord-023095-4dannjjm 3131 10 duplication duplication NN cord-023095-4dannjjm 3131 11 and and CC cord-023095-4dannjjm 3131 12 have have VBP cord-023095-4dannjjm 3131 13 identical identical JJ cord-023095-4dannjjm 3131 14 protein protein NN cord-023095-4dannjjm 3131 15 sequence sequence NN cord-023095-4dannjjm 3131 16 . . . cord-023095-4dannjjm 3132 1 CanHBB1/2 CanHBB1/2 NNP cord-023095-4dannjjm 3132 2 are be VBP cord-023095-4dannjjm 3132 3 abundantly abundantly RB cord-023095-4dannjjm 3132 4 expressed express VBN cord-023095-4dannjjm 3132 5 in in IN cord-023095-4dannjjm 3132 6 adults adult NNS cord-023095-4dannjjm 3132 7 ; ; : cord-023095-4dannjjm 3132 8 CanHBB3 CanHBB3 NNS cord-023095-4dannjjm 3132 9 is be VBZ cord-023095-4dannjjm 3132 10 expressed express VBN cord-023095-4dannjjm 3132 11 at at IN cord-023095-4dannjjm 3132 12 greatly greatly RB cord-023095-4dannjjm 3132 13 reduced reduce VBN cord-023095-4dannjjm 3132 14 levels level NNS cord-023095-4dannjjm 3132 15 . . . cord-023095-4dannjjm 3133 1 Sequencing sequencing NN cord-023095-4dannjjm 3133 2 results result NNS cord-023095-4dannjjm 3133 3 revealed reveal VBD cord-023095-4dannjjm 3133 4 one one CD cord-023095-4dannjjm 3133 5 rare rare JJ cord-023095-4dannjjm 3133 6 non non JJ cord-023095-4dannjjm 3133 7 - - JJ cord-023095-4dannjjm 3133 8 synonymous synonymous JJ cord-023095-4dannjjm 3133 9 single single JJ cord-023095-4dannjjm 3133 10 nucleotide nucleotide JJ cord-023095-4dannjjm 3133 11 polymorphism polymorphism NN cord-023095-4dannjjm 3133 12 ( ( -LRB- cord-023095-4dannjjm 3133 13 SNP SNP NNP cord-023095-4dannjjm 3133 14 ) ) -RRB- cord-023095-4dannjjm 3133 15 in in IN cord-023095-4dannjjm 3133 16 HBE1 HBE1 NNP cord-023095-4dannjjm 3133 17 of of IN cord-023095-4dannjjm 3133 18 RRGs rrg NNS cord-023095-4dannjjm 3133 19 , , , cord-023095-4dannjjm 3133 20 but but CC cord-023095-4dannjjm 3133 21 no no DT cord-023095-4dannjjm 3133 22 variation variation NN cord-023095-4dannjjm 3133 23 that that WDT cord-023095-4dannjjm 3133 24 could could MD cord-023095-4dannjjm 3133 25 explain explain VB cord-023095-4dannjjm 3133 26 their -PRON- PRP$ cord-023095-4dannjjm 3133 27 abnormal abnormal JJ cord-023095-4dannjjm 3133 28 hemoglobin hemoglobin NN cord-023095-4dannjjm 3133 29 . . . cord-023095-4dannjjm 3134 1 We -PRON- PRP cord-023095-4dannjjm 3134 2 did do VBD cord-023095-4dannjjm 3134 3 not not RB cord-023095-4dannjjm 3134 4 detect detect VB cord-023095-4dannjjm 3134 5 structural structural JJ cord-023095-4dannjjm 3134 6 variation variation NN cord-023095-4dannjjm 3134 7 overlapping overlap VBG cord-023095-4dannjjm 3134 8 or or CC cord-023095-4dannjjm 3134 9 near near IN cord-023095-4dannjjm 3134 10 the the DT cord-023095-4dannjjm 3134 11 beta beta JJ cord-023095-4dannjjm 3134 12 globin globin NN cord-023095-4dannjjm 3134 13 locus locus NN cord-023095-4dannjjm 3134 14 . . . cord-023095-4dannjjm 3135 1 Notably notably RB cord-023095-4dannjjm 3135 2 , , , cord-023095-4dannjjm 3135 3 RRG RRG NNP cord-023095-4dannjjm 3135 4 and and CC cord-023095-4dannjjm 3135 5 AKCG AKCG NNP cord-023095-4dannjjm 3135 6 do do VBP cord-023095-4dannjjm 3135 7 not not RB cord-023095-4dannjjm 3135 8 share share VB cord-023095-4dannjjm 3135 9 haplotypes haplotype NNS cord-023095-4dannjjm 3135 10 spanning span VBG cord-023095-4dannjjm 3135 11 the the DT cord-023095-4dannjjm 3135 12 beta beta JJ cord-023095-4dannjjm 3135 13 globin globin NN cord-023095-4dannjjm 3135 14 locus locus NN cord-023095-4dannjjm 3135 15 . . . cord-023095-4dannjjm 3136 1 This this DT cord-023095-4dannjjm 3136 2 is be VBZ cord-023095-4dannjjm 3136 3 the the DT cord-023095-4dannjjm 3136 4 first first JJ cord-023095-4dannjjm 3136 5 characterization characterization NN cord-023095-4dannjjm 3136 6 of of IN cord-023095-4dannjjm 3136 7 canine canine JJ cord-023095-4dannjjm 3136 8 hemoglobin hemoglobin NN cord-023095-4dannjjm 3136 9 genetics genetic NNS cord-023095-4dannjjm 3136 10 , , , cord-023095-4dannjjm 3136 11 and and CC cord-023095-4dannjjm 3136 12 the the DT cord-023095-4dannjjm 3136 13 first first JJ cord-023095-4dannjjm 3136 14 report report NN cord-023095-4dannjjm 3136 15 of of IN cord-023095-4dannjjm 3136 16 canine canine JJ cord-023095-4dannjjm 3136 17 embryonic embryonic JJ cord-023095-4dannjjm 3136 18 hemoglobins hemoglobin NNS cord-023095-4dannjjm 3136 19 and and CC cord-023095-4dannjjm 3136 20 their -PRON- PRP$ cord-023095-4dannjjm 3136 21 expression expression NN cord-023095-4dannjjm 3136 22 in in IN cord-023095-4dannjjm 3136 23 adults adult NNS cord-023095-4dannjjm 3136 24 . . . cord-023095-4dannjjm 3137 1 Sampling sampling NN cord-023095-4dannjjm 3137 2 of of IN cord-023095-4dannjjm 3137 3 the the DT cord-023095-4dannjjm 3137 4 bone bone NN cord-023095-4dannjjm 3137 5 marrow marrow NN cord-023095-4dannjjm 3137 6 in in IN cord-023095-4dannjjm 3137 7 the the DT cord-023095-4dannjjm 3137 8 dog dog NN cord-023095-4dannjjm 3137 9 from from IN cord-023095-4dannjjm 3137 10 the the DT cord-023095-4dannjjm 3137 11 costochondral costochondral JJ cord-023095-4dannjjm 3137 12 ( ( -LRB- cord-023095-4dannjjm 3137 13 CC CC NNP cord-023095-4dannjjm 3137 14 ) ) -RRB- cord-023095-4dannjjm 3137 15 junction junction NN cord-023095-4dannjjm 3137 16 can can MD cord-023095-4dannjjm 3137 17 be be VB cord-023095-4dannjjm 3137 18 performed perform VBN cord-023095-4dannjjm 3137 19 with with IN cord-023095-4dannjjm 3137 20 minimal minimal JJ cord-023095-4dannjjm 3137 21 to to IN cord-023095-4dannjjm 3137 22 no no DT cord-023095-4dannjjm 3137 23 sedation sedation NN cord-023095-4dannjjm 3137 24 and and CC cord-023095-4dannjjm 3137 25 readily readily RB cord-023095-4dannjjm 3137 26 available available JJ cord-023095-4dannjjm 3137 27 equipment equipment NN cord-023095-4dannjjm 3137 28 but but CC cord-023095-4dannjjm 3137 29 is be VBZ cord-023095-4dannjjm 3137 30 not not RB cord-023095-4dannjjm 3137 31 in in IN cord-023095-4dannjjm 3137 32 widespread widespread JJ cord-023095-4dannjjm 3137 33 use use NN cord-023095-4dannjjm 3137 34 in in IN cord-023095-4dannjjm 3137 35 the the DT cord-023095-4dannjjm 3137 36 United United NNP cord-023095-4dannjjm 3137 37 States States NNP cord-023095-4dannjjm 3137 38 . . . cord-023095-4dannjjm 3138 1 The the DT cord-023095-4dannjjm 3138 2 aim aim NN cord-023095-4dannjjm 3138 3 of of IN cord-023095-4dannjjm 3138 4 this this DT cord-023095-4dannjjm 3138 5 study study NN cord-023095-4dannjjm 3138 6 was be VBD cord-023095-4dannjjm 3138 7 to to TO cord-023095-4dannjjm 3138 8 compare compare VB cord-023095-4dannjjm 3138 9 the the DT cord-023095-4dannjjm 3138 10 number number NN cord-023095-4dannjjm 3138 11 of of IN cord-023095-4dannjjm 3138 12 attempts attempt NNS cord-023095-4dannjjm 3138 13 needed need VBN cord-023095-4dannjjm 3138 14 to to TO cord-023095-4dannjjm 3138 15 successfully successfully RB cord-023095-4dannjjm 3138 16 obtain obtain VB cord-023095-4dannjjm 3138 17 a a DT cord-023095-4dannjjm 3138 18 sample sample NN cord-023095-4dannjjm 3138 19 , , , cord-023095-4dannjjm 3138 20 the the DT cord-023095-4dannjjm 3138 21 time time NN cord-023095-4dannjjm 3138 22 needed need VBN cord-023095-4dannjjm 3138 23 for for IN cord-023095-4dannjjm 3138 24 the the DT cord-023095-4dannjjm 3138 25 procedure procedure NN cord-023095-4dannjjm 3138 26 , , , cord-023095-4dannjjm 3138 27 and and CC cord-023095-4dannjjm 3138 28 the the DT cord-023095-4dannjjm 3138 29 sample sample NN cord-023095-4dannjjm 3138 30 quality quality NN cord-023095-4dannjjm 3138 31 between between IN cord-023095-4dannjjm 3138 32 aspirates aspirate NNS cord-023095-4dannjjm 3138 33 obtained obtain VBN cord-023095-4dannjjm 3138 34 from from IN cord-023095-4dannjjm 3138 35 the the DT cord-023095-4dannjjm 3138 36 CC CC NNP cord-023095-4dannjjm 3138 37 junction junction NN cord-023095-4dannjjm 3138 38 and and CC cord-023095-4dannjjm 3138 39 more more JJR cord-023095-4dannjjm 3138 40 traditional traditional JJ cord-023095-4dannjjm 3138 41 sites site NNS cord-023095-4dannjjm 3138 42 ( ( -LRB- cord-023095-4dannjjm 3138 43 humerus humerus NN cord-023095-4dannjjm 3138 44 or or CC cord-023095-4dannjjm 3138 45 femur femur NN cord-023095-4dannjjm 3138 46 ) ) -RRB- cord-023095-4dannjjm 3138 47 in in IN cord-023095-4dannjjm 3138 48 healthy healthy JJ cord-023095-4dannjjm 3138 49 dogs dog NNS cord-023095-4dannjjm 3138 50 when when WRB cord-023095-4dannjjm 3138 51 performed perform VBN cord-023095-4dannjjm 3138 52 by by IN cord-023095-4dannjjm 3138 53 novice novice NN cord-023095-4dannjjm 3138 54 and and CC cord-023095-4dannjjm 3138 55 seasoned seasoned JJ cord-023095-4dannjjm 3138 56 practitioners practitioner NNS cord-023095-4dannjjm 3138 57 . . . cord-023095-4dannjjm 3139 1 Samples sample NNS cord-023095-4dannjjm 3139 2 were be VBD cord-023095-4dannjjm 3139 3 obtained obtain VBN cord-023095-4dannjjm 3139 4 from from IN cord-023095-4dannjjm 3139 5 healthy healthy JJ cord-023095-4dannjjm 3139 6 anesthetized anesthetized JJ cord-023095-4dannjjm 3139 7 laboratory laboratory NN cord-023095-4dannjjm 3139 8 reared rear VBD cord-023095-4dannjjm 3139 9 adult adult NN cord-023095-4dannjjm 3139 10 dogs dog NNS cord-023095-4dannjjm 3139 11 after after IN cord-023095-4dannjjm 3139 12 undergoing undergo VBG cord-023095-4dannjjm 3139 13 terminal terminal JJ cord-023095-4dannjjm 3139 14 endoscopic endoscopic NNS cord-023095-4dannjjm 3139 15 surgery surgery NN cord-023095-4dannjjm 3139 16 . . . cord-023095-4dannjjm 3140 1 Paired pair VBN cord-023095-4dannjjm 3140 2 samples sample NNS cord-023095-4dannjjm 3140 3 from from IN cord-023095-4dannjjm 3140 4 separate separate JJ cord-023095-4dannjjm 3140 5 dogs dog NNS cord-023095-4dannjjm 3140 6 were be VBD cord-023095-4dannjjm 3140 7 obtained obtain VBN cord-023095-4dannjjm 3140 8 by by IN cord-023095-4dannjjm 3140 9 each each DT cord-023095-4dannjjm 3140 10 practitioner practitioner NN cord-023095-4dannjjm 3140 11 using use VBG cord-023095-4dannjjm 3140 12 either either CC cord-023095-4dannjjm 3140 13 a a DT cord-023095-4dannjjm 3140 14 22 22 CD cord-023095-4dannjjm 3140 15 gauge gauge NN cord-023095-4dannjjm 3140 16 needle needle NN cord-023095-4dannjjm 3140 17 and and CC cord-023095-4dannjjm 3140 18 6 6 CD cord-023095-4dannjjm 3140 19 cc cc NN cord-023095-4dannjjm 3140 20 syringe syringe NN cord-023095-4dannjjm 3140 21 at at IN cord-023095-4dannjjm 3140 22 the the DT cord-023095-4dannjjm 3140 23 CC CC NNP cord-023095-4dannjjm 3140 24 junction junction NN cord-023095-4dannjjm 3140 25 or or CC cord-023095-4dannjjm 3140 26 an an DT cord-023095-4dannjjm 3140 27 18 18 CD cord-023095-4dannjjm 3140 28 gauge gauge NN cord-023095-4dannjjm 3140 29 Rosenthal Rosenthal NNP cord-023095-4dannjjm 3140 30 needle needle NN cord-023095-4dannjjm 3140 31 and and CC cord-023095-4dannjjm 3140 32 12 12 CD cord-023095-4dannjjm 3140 33 cc cc NN cord-023095-4dannjjm 3140 34 syringe syringe NN cord-023095-4dannjjm 3140 35 from from IN cord-023095-4dannjjm 3140 36 either either CC cord-023095-4dannjjm 3140 37 the the DT cord-023095-4dannjjm 3140 38 proximal proximal JJ cord-023095-4dannjjm 3140 39 humerus humerus NN cord-023095-4dannjjm 3140 40 or or CC cord-023095-4dannjjm 3140 41 femur femur NN cord-023095-4dannjjm 3140 42 ( ( -LRB- cord-023095-4dannjjm 3140 43 clinician clinician NN cord-023095-4dannjjm 3140 44 preference preference NN cord-023095-4dannjjm 3140 45 ) ) -RRB- cord-023095-4dannjjm 3140 46 . . . cord-023095-4dannjjm 3141 1 Three three CD cord-023095-4dannjjm 3141 2 small small JJ cord-023095-4dannjjm 3141 3 animal animal NN cord-023095-4dannjjm 3141 4 veterinary veterinary JJ cord-023095-4dannjjm 3141 5 interns intern NNS cord-023095-4dannjjm 3141 6 , , , cord-023095-4dannjjm 3141 7 one one CD cord-023095-4dannjjm 3141 8 experienced experienced JJ cord-023095-4dannjjm 3141 9 technician technician NN cord-023095-4dannjjm 3141 10 and and CC cord-023095-4dannjjm 3141 11 one one CD cord-023095-4dannjjm 3141 12 boarded board VBN cord-023095-4dannjjm 3141 13 internist internist NN cord-023095-4dannjjm 3141 14 were be VBD cord-023095-4dannjjm 3141 15 monitored monitor VBN cord-023095-4dannjjm 3141 16 for for IN cord-023095-4dannjjm 3141 17 number number NN cord-023095-4dannjjm 3141 18 of of IN cord-023095-4dannjjm 3141 19 attempts attempt NNS cord-023095-4dannjjm 3141 20 to to IN cord-023095-4dannjjm 3141 21 success success NN cord-023095-4dannjjm 3141 22 and and CC cord-023095-4dannjjm 3141 23 length length NN cord-023095-4dannjjm 3141 24 of of IN cord-023095-4dannjjm 3141 25 time time NN cord-023095-4dannjjm 3141 26 needed need VBN cord-023095-4dannjjm 3141 27 for for IN cord-023095-4dannjjm 3141 28 success success NN cord-023095-4dannjjm 3141 29 of of IN cord-023095-4dannjjm 3141 30 each each DT cord-023095-4dannjjm 3141 31 procedure procedure NN cord-023095-4dannjjm 3141 32 . . . cord-023095-4dannjjm 3142 1 Slides slide NNS cord-023095-4dannjjm 3142 2 were be VBD cord-023095-4dannjjm 3142 3 prepared prepare VBN cord-023095-4dannjjm 3142 4 by by IN cord-023095-4dannjjm 3142 5 a a DT cord-023095-4dannjjm 3142 6 single single JJ cord-023095-4dannjjm 3142 7 investigator investigator NN cord-023095-4dannjjm 3142 8 and and CC cord-023095-4dannjjm 3142 9 read read VBN cord-023095-4dannjjm 3142 10 by by IN cord-023095-4dannjjm 3142 11 a a DT cord-023095-4dannjjm 3142 12 blinded blind VBN cord-023095-4dannjjm 3142 13 clinical clinical JJ cord-023095-4dannjjm 3142 14 pathologist pathologist NN cord-023095-4dannjjm 3142 15 . . . cord-023095-4dannjjm 3143 1 Data datum NNS cord-023095-4dannjjm 3143 2 were be VBD cord-023095-4dannjjm 3143 3 compared compare VBN cord-023095-4dannjjm 3143 4 using use VBG cord-023095-4dannjjm 3143 5 the the DT cord-023095-4dannjjm 3143 6 paired paired JJ cord-023095-4dannjjm 3143 7 t t NN cord-023095-4dannjjm 3143 8 - - HYPH cord-023095-4dannjjm 3143 9 test test NN cord-023095-4dannjjm 3143 10 for for IN cord-023095-4dannjjm 3143 11 normally normally RB cord-023095-4dannjjm 3143 12 distributed distribute VBN cord-023095-4dannjjm 3143 13 data datum NNS cord-023095-4dannjjm 3143 14 and and CC cord-023095-4dannjjm 3143 15 Wilcoxen Wilcoxen NNP cord-023095-4dannjjm 3143 16 signed sign VBD cord-023095-4dannjjm 3143 17 rank rank NN cord-023095-4dannjjm 3143 18 test test NN cord-023095-4dannjjm 3143 19 for for IN cord-023095-4dannjjm 3143 20 non non JJ cord-023095-4dannjjm 3143 21 - - JJ cord-023095-4dannjjm 3143 22 Gaussian gaussian JJ cord-023095-4dannjjm 3143 23 distributions distribution NNS cord-023095-4dannjjm 3143 24 . . . cord-023095-4dannjjm 3144 1 Five five CD cord-023095-4dannjjm 3144 2 pairs pair NNS cord-023095-4dannjjm 3144 3 of of IN cord-023095-4dannjjm 3144 4 samples sample NNS cord-023095-4dannjjm 3144 5 from from IN cord-023095-4dannjjm 3144 6 three three CD cord-023095-4dannjjm 3144 7 dogs dog NNS cord-023095-4dannjjm 3144 8 were be VBD cord-023095-4dannjjm 3144 9 evaluated evaluate VBN cord-023095-4dannjjm 3144 10 . . . cord-023095-4dannjjm 3145 1 Two two CD cord-023095-4dannjjm 3145 2 dogs dog NNS cord-023095-4dannjjm 3145 3 had have VBD cord-023095-4dannjjm 3145 4 two two CD cord-023095-4dannjjm 3145 5 pairs pair NNS cord-023095-4dannjjm 3145 6 drawn draw VBN cord-023095-4dannjjm 3145 7 from from IN cord-023095-4dannjjm 3145 8 opposite opposite JJ cord-023095-4dannjjm 3145 9 limbs limb NNS cord-023095-4dannjjm 3145 10 and and CC cord-023095-4dannjjm 3145 11 ribs rib NNS cord-023095-4dannjjm 3145 12 . . . cord-023095-4dannjjm 3146 1 Mean mean JJ cord-023095-4dannjjm 3146 2 number number NN cord-023095-4dannjjm 3146 3 of of IN cord-023095-4dannjjm 3146 4 attempts attempt NNS cord-023095-4dannjjm 3146 5 to to IN cord-023095-4dannjjm 3146 6 success success NN cord-023095-4dannjjm 3146 7 for for IN cord-023095-4dannjjm 3146 8 traditional traditional JJ cord-023095-4dannjjm 3146 9 sampling sampling NN cord-023095-4dannjjm 3146 10 sites site NNS cord-023095-4dannjjm 3146 11 ( ( -LRB- cord-023095-4dannjjm 3146 12 1.4 1.4 CD cord-023095-4dannjjm 3146 13 1 1 CD cord-023095-4dannjjm 3146 14 / / SYM cord-023095-4dannjjm 3146 15 À0.54 À0.54 NNP cord-023095-4dannjjm 3146 16 ) ) -RRB- cord-023095-4dannjjm 3146 17 and and CC cord-023095-4dannjjm 3146 18 time time NN cord-023095-4dannjjm 3146 19 to to IN cord-023095-4dannjjm 3146 20 success success NN cord-023095-4dannjjm 3146 21 ( ( -LRB- cord-023095-4dannjjm 3146 22 8.6 8.6 CD cord-023095-4dannjjm 3146 23 minutes minute NNS cord-023095-4dannjjm 3146 24 1 1 CD cord-023095-4dannjjm 3146 25 / / SYM cord-023095-4dannjjm 3146 26 À5.2 à5.2 NN cord-023095-4dannjjm 3146 27 ) ) -RRB- cord-023095-4dannjjm 3146 28 did do VBD cord-023095-4dannjjm 3146 29 not not RB cord-023095-4dannjjm 3146 30 differ differ VB cord-023095-4dannjjm 3146 31 significantly significantly RB cord-023095-4dannjjm 3146 32 from from IN cord-023095-4dannjjm 3146 33 attempts attempt NNS cord-023095-4dannjjm 3146 34 ( ( -LRB- cord-023095-4dannjjm 3146 35 2.01/-0.70 2.01/-0.70 CD cord-023095-4dannjjm 3146 36 , , , cord-023095-4dannjjm 3146 37 p p NN cord-023095-4dannjjm 3146 38 5 5 CD cord-023095-4dannjjm 3146 39 0.25 0.25 CD cord-023095-4dannjjm 3146 40 ) ) -RRB- cord-023095-4dannjjm 3146 41 or or CC cord-023095-4dannjjm 3146 42 time time NN cord-023095-4dannjjm 3146 43 ( ( -LRB- cord-023095-4dannjjm 3146 44 2.7 2.7 CD cord-023095-4dannjjm 3146 45 1/-0.98 1/-0.98 CD cord-023095-4dannjjm 3146 46 , , , cord-023095-4dannjjm 3146 47 0.06 0.06 CD cord-023095-4dannjjm 3146 48 ) ) -RRB- cord-023095-4dannjjm 3146 49 needed need VBD cord-023095-4dannjjm 3146 50 when when WRB cord-023095-4dannjjm 3146 51 aspirating aspirate VBG cord-023095-4dannjjm 3146 52 from from IN cord-023095-4dannjjm 3146 53 the the DT cord-023095-4dannjjm 3146 54 CC CC NNP cord-023095-4dannjjm 3146 55 junction junction NN cord-023095-4dannjjm 3146 56 . . . cord-023095-4dannjjm 3147 1 Subjectively subjectively RB cord-023095-4dannjjm 3147 2 , , , cord-023095-4dannjjm 3147 3 samples sample NNS cord-023095-4dannjjm 3147 4 were be VBD cord-023095-4dannjjm 3147 5 of of IN cord-023095-4dannjjm 3147 6 similar similar JJ cord-023095-4dannjjm 3147 7 quality quality NN cord-023095-4dannjjm 3147 8 with with IN cord-023095-4dannjjm 3147 9 regards regard NNS cord-023095-4dannjjm 3147 10 to to IN cord-023095-4dannjjm 3147 11 cellularity cellularity NN cord-023095-4dannjjm 3147 12 and and CC cord-023095-4dannjjm 3147 13 number number NN cord-023095-4dannjjm 3147 14 of of IN cord-023095-4dannjjm 3147 15 particles particle NNS cord-023095-4dannjjm 3147 16 present present JJ cord-023095-4dannjjm 3147 17 when when WRB cord-023095-4dannjjm 3147 18 compared compare VBN cord-023095-4dannjjm 3147 19 within within IN cord-023095-4dannjjm 3147 20 practitioners practitioner NNS cord-023095-4dannjjm 3147 21 . . . cord-023095-4dannjjm 3148 1 Myeloid myeloid NN cord-023095-4dannjjm 3148 2 : : : cord-023095-4dannjjm 3148 3 erythroid erythroid NN cord-023095-4dannjjm 3148 4 ratio ratio NN cord-023095-4dannjjm 3148 5 and and CC cord-023095-4dannjjm 3148 6 percentage percentage NN cord-023095-4dannjjm 3148 7 of of IN cord-023095-4dannjjm 3148 8 lymphocytes lymphocyte NNS cord-023095-4dannjjm 3148 9 were be VBD cord-023095-4dannjjm 3148 10 also also RB cord-023095-4dannjjm 3148 11 not not RB cord-023095-4dannjjm 3148 12 significantly significantly RB cord-023095-4dannjjm 3148 13 different different JJ cord-023095-4dannjjm 3148 14 between between IN cord-023095-4dannjjm 3148 15 sites site NNS cord-023095-4dannjjm 3148 16 ( ( -LRB- cord-023095-4dannjjm 3148 17 M m NN cord-023095-4dannjjm 3148 18 : : : cord-023095-4dannjjm 3148 19 E e NN cord-023095-4dannjjm 3148 20 ratio ratio NN cord-023095-4dannjjm 3148 21 p p NN cord-023095-4dannjjm 3148 22 5 5 CD cord-023095-4dannjjm 3148 23 0.37 0.37 CD cord-023095-4dannjjm 3148 24 , , , cord-023095-4dannjjm 3148 25 lymphocyte lymphocyte NN cord-023095-4dannjjm 3148 26 % % NN cord-023095-4dannjjm 3148 27 p p NN cord-023095-4dannjjm 3148 28 5 5 CD cord-023095-4dannjjm 3148 29 0.07 0.07 CD cord-023095-4dannjjm 3148 30 ) ) -RRB- cord-023095-4dannjjm 3148 31 and and CC cord-023095-4dannjjm 3148 32 were be VBD cord-023095-4dannjjm 3148 33 within within IN cord-023095-4dannjjm 3148 34 normal normal JJ cord-023095-4dannjjm 3148 35 limits limit NNS cord-023095-4dannjjm 3148 36 . . . cord-023095-4dannjjm 3149 1 While while IN cord-023095-4dannjjm 3149 2 there there EX cord-023095-4dannjjm 3149 3 were be VBD cord-023095-4dannjjm 3149 4 no no DT cord-023095-4dannjjm 3149 5 significant significant JJ cord-023095-4dannjjm 3149 6 differences difference NNS cord-023095-4dannjjm 3149 7 between between IN cord-023095-4dannjjm 3149 8 the the DT cord-023095-4dannjjm 3149 9 two two CD cord-023095-4dannjjm 3149 10 sites site NNS cord-023095-4dannjjm 3149 11 in in IN cord-023095-4dannjjm 3149 12 terms term NNS cord-023095-4dannjjm 3149 13 of of IN cord-023095-4dannjjm 3149 14 number number NN cord-023095-4dannjjm 3149 15 of of IN cord-023095-4dannjjm 3149 16 attempts attempt NNS cord-023095-4dannjjm 3149 17 or or CC cord-023095-4dannjjm 3149 18 time time NN cord-023095-4dannjjm 3149 19 to to IN cord-023095-4dannjjm 3149 20 success success NN cord-023095-4dannjjm 3149 21 , , , cord-023095-4dannjjm 3149 22 it -PRON- PRP cord-023095-4dannjjm 3149 23 should should MD cord-023095-4dannjjm 3149 24 be be VB cord-023095-4dannjjm 3149 25 noted note VBN cord-023095-4dannjjm 3149 26 that that IN cord-023095-4dannjjm 3149 27 the the DT cord-023095-4dannjjm 3149 28 ' ' `` cord-023095-4dannjjm 3149 29 ' ' `` cord-023095-4dannjjm 3149 30 seasoned season VBN cord-023095-4dannjjm 3149 31 ' ' '' cord-023095-4dannjjm 3149 32 ' ' '' cord-023095-4dannjjm 3149 33 practitioners practitioner NNS cord-023095-4dannjjm 3149 34 had have VBD cord-023095-4dannjjm 3149 35 never never RB cord-023095-4dannjjm 3149 36 performed perform VBN cord-023095-4dannjjm 3149 37 an an DT cord-023095-4dannjjm 3149 38 aspirate aspirate NN cord-023095-4dannjjm 3149 39 at at IN cord-023095-4dannjjm 3149 40 the the DT cord-023095-4dannjjm 3149 41 CC CC NNP cord-023095-4dannjjm 3149 42 site site NN cord-023095-4dannjjm 3149 43 and and CC cord-023095-4dannjjm 3149 44 had have VBD cord-023095-4dannjjm 3149 45 an an DT cord-023095-4dannjjm 3149 46 increased increase VBN cord-023095-4dannjjm 3149 47 number number NN cord-023095-4dannjjm 3149 48 of of IN cord-023095-4dannjjm 3149 49 attempts attempt NNS cord-023095-4dannjjm 3149 50 compared compare VBN cord-023095-4dannjjm 3149 51 to to IN cord-023095-4dannjjm 3149 52 the the DT cord-023095-4dannjjm 3149 53 traditional traditional JJ cord-023095-4dannjjm 3149 54 sites site NNS cord-023095-4dannjjm 3149 55 . . . cord-023095-4dannjjm 3150 1 If if IN cord-023095-4dannjjm 3150 2 the the DT cord-023095-4dannjjm 3150 3 number number NN cord-023095-4dannjjm 3150 4 of of IN cord-023095-4dannjjm 3150 5 attempts attempt NNS cord-023095-4dannjjm 3150 6 needed need VBN cord-023095-4dannjjm 3150 7 for for IN cord-023095-4dannjjm 3150 8 success success NN cord-023095-4dannjjm 3150 9 decreases decrease VBZ cord-023095-4dannjjm 3150 10 with with IN cord-023095-4dannjjm 3150 11 experience experience NN cord-023095-4dannjjm 3150 12 , , , cord-023095-4dannjjm 3150 13 it -PRON- PRP cord-023095-4dannjjm 3150 14 is be VBZ cord-023095-4dannjjm 3150 15 likely likely RB cord-023095-4dannjjm 3150 16 the the DT cord-023095-4dannjjm 3150 17 time time NN cord-023095-4dannjjm 3150 18 required require VBN cord-023095-4dannjjm 3150 19 would would MD cord-023095-4dannjjm 3150 20 decrease decrease VB cord-023095-4dannjjm 3150 21 as as RB cord-023095-4dannjjm 3150 22 well well RB cord-023095-4dannjjm 3150 23 . . . cord-023095-4dannjjm 3151 1 Both both DT cord-023095-4dannjjm 3151 2 subjectively subjectively RB cord-023095-4dannjjm 3151 3 and and CC cord-023095-4dannjjm 3151 4 objectively objectively RB cord-023095-4dannjjm 3151 5 , , , cord-023095-4dannjjm 3151 6 there there EX cord-023095-4dannjjm 3151 7 were be VBD cord-023095-4dannjjm 3151 8 no no DT cord-023095-4dannjjm 3151 9 significant significant JJ cord-023095-4dannjjm 3151 10 differences difference NNS cord-023095-4dannjjm 3151 11 in in IN cord-023095-4dannjjm 3151 12 quality quality NN cord-023095-4dannjjm 3151 13 or or CC cord-023095-4dannjjm 3151 14 cell cell NN cord-023095-4dannjjm 3151 15 populations population NNS cord-023095-4dannjjm 3151 16 between between IN cord-023095-4dannjjm 3151 17 the the DT cord-023095-4dannjjm 3151 18 two two CD cord-023095-4dannjjm 3151 19 sampling sampling NN cord-023095-4dannjjm 3151 20 sites site NNS cord-023095-4dannjjm 3151 21 in in IN cord-023095-4dannjjm 3151 22 healthy healthy JJ cord-023095-4dannjjm 3151 23 dogs dog NNS cord-023095-4dannjjm 3151 24 . . . cord-023095-4dannjjm 3152 1 Based base VBN cord-023095-4dannjjm 3152 2 on on IN cord-023095-4dannjjm 3152 3 this this DT cord-023095-4dannjjm 3152 4 data data NN cord-023095-4dannjjm 3152 5 , , , cord-023095-4dannjjm 3152 6 bone bone NN cord-023095-4dannjjm 3152 7 marrow marrow NN cord-023095-4dannjjm 3152 8 aspiration aspiration NN cord-023095-4dannjjm 3152 9 from from IN cord-023095-4dannjjm 3152 10 the the DT cord-023095-4dannjjm 3152 11 CC CC NNP cord-023095-4dannjjm 3152 12 junction junction NN cord-023095-4dannjjm 3152 13 appears appear VBZ cord-023095-4dannjjm 3152 14 to to TO cord-023095-4dannjjm 3152 15 be be VB cord-023095-4dannjjm 3152 16 equivalent equivalent JJ cord-023095-4dannjjm 3152 17 to to IN cord-023095-4dannjjm 3152 18 more more JJR cord-023095-4dannjjm 3152 19 traditional traditional JJ cord-023095-4dannjjm 3152 20 sampling sampling NN cord-023095-4dannjjm 3152 21 sites site NNS cord-023095-4dannjjm 3152 22 in in IN cord-023095-4dannjjm 3152 23 healthy healthy JJ cord-023095-4dannjjm 3152 24 dogs dog NNS cord-023095-4dannjjm 3152 25 . . . cord-023095-4dannjjm 3153 1 Larger large JJR cord-023095-4dannjjm 3153 2 studies study NNS cord-023095-4dannjjm 3153 3 in in IN cord-023095-4dannjjm 3153 4 clinically clinically RB cord-023095-4dannjjm 3153 5 ill ill JJ cord-023095-4dannjjm 3153 6 dogs dog NNS cord-023095-4dannjjm 3153 7 should should MD cord-023095-4dannjjm 3153 8 be be VB cord-023095-4dannjjm 3153 9 performed perform VBN cord-023095-4dannjjm 3153 10 before before IN cord-023095-4dannjjm 3153 11 routinely routinely RB cord-023095-4dannjjm 3153 12 using use VBG cord-023095-4dannjjm 3153 13 the the DT cord-023095-4dannjjm 3153 14 site site NN cord-023095-4dannjjm 3153 15 in in IN cord-023095-4dannjjm 3153 16 the the DT cord-023095-4dannjjm 3153 17 clinical clinical JJ cord-023095-4dannjjm 3153 18 setting setting NN cord-023095-4dannjjm 3153 19 . . . cord-023095-4dannjjm 3154 1 Recent recent JJ cord-023095-4dannjjm 3154 2 research research NN cord-023095-4dannjjm 3154 3 on on IN cord-023095-4dannjjm 3154 4 iron iron NN cord-023095-4dannjjm 3154 5 homeostasis homeostasis NN cord-023095-4dannjjm 3154 6 has have VBZ cord-023095-4dannjjm 3154 7 elucidated elucidate VBN cord-023095-4dannjjm 3154 8 the the DT cord-023095-4dannjjm 3154 9 tightly tightly RB cord-023095-4dannjjm 3154 10 controlled control VBN cord-023095-4dannjjm 3154 11 intestinal intestinal JJ cord-023095-4dannjjm 3154 12 uptake uptake NN cord-023095-4dannjjm 3154 13 of of IN cord-023095-4dannjjm 3154 14 iron iron NN cord-023095-4dannjjm 3154 15 . . . cord-023095-4dannjjm 3155 1 Hepcidin Hepcidin NNP cord-023095-4dannjjm 3155 2 , , , cord-023095-4dannjjm 3155 3 the the DT cord-023095-4dannjjm 3155 4 major major JJ cord-023095-4dannjjm 3155 5 hormone hormone NN cord-023095-4dannjjm 3155 6 limiting limit VBG cord-023095-4dannjjm 3155 7 iron iron NN cord-023095-4dannjjm 3155 8 absorption absorption NN cord-023095-4dannjjm 3155 9 and and CC cord-023095-4dannjjm 3155 10 release release NN cord-023095-4dannjjm 3155 11 from from IN cord-023095-4dannjjm 3155 12 macrophages macrophage NNS cord-023095-4dannjjm 3155 13 , , , cord-023095-4dannjjm 3155 14 is be VBZ cord-023095-4dannjjm 3155 15 downregulated downregulate VBN cord-023095-4dannjjm 3155 16 by by IN cord-023095-4dannjjm 3155 17 matriptase-2 matriptase-2 NNP cord-023095-4dannjjm 3155 18 , , , cord-023095-4dannjjm 3155 19 a a DT cord-023095-4dannjjm 3155 20 transmembrane transmembrane NN cord-023095-4dannjjm 3155 21 serine serine NN cord-023095-4dannjjm 3155 22 protease protease NN cord-023095-4dannjjm 3155 23 ( ( -LRB- cord-023095-4dannjjm 3155 24 Tmprss6 Tmprss6 NNP cord-023095-4dannjjm 3155 25 ) ) -RRB- cord-023095-4dannjjm 3155 26 produced produce VBN cord-023095-4dannjjm 3155 27 by by IN cord-023095-4dannjjm 3155 28 the the DT cord-023095-4dannjjm 3155 29 liver liver NN cord-023095-4dannjjm 3155 30 . . . cord-023095-4dannjjm 3156 1 While while IN cord-023095-4dannjjm 3156 2 iron iron NN cord-023095-4dannjjm 3156 3 deficiency deficiency NN cord-023095-4dannjjm 3156 4 is be VBZ cord-023095-4dannjjm 3156 5 commonly commonly RB cord-023095-4dannjjm 3156 6 caused cause VBN cord-023095-4dannjjm 3156 7 by by IN cord-023095-4dannjjm 3156 8 chronic chronic JJ cord-023095-4dannjjm 3156 9 blood blood NN cord-023095-4dannjjm 3156 10 loss loss NN cord-023095-4dannjjm 3156 11 anemia anemia NN cord-023095-4dannjjm 3156 12 and and CC cord-023095-4dannjjm 3156 13 rarely rarely RB cord-023095-4dannjjm 3156 14 dietary dietary JJ cord-023095-4dannjjm 3156 15 deficiency deficiency NN cord-023095-4dannjjm 3156 16 or or CC cord-023095-4dannjjm 3156 17 intestinal intestinal JJ cord-023095-4dannjjm 3156 18 disorders disorder NNS cord-023095-4dannjjm 3156 19 in in IN cord-023095-4dannjjm 3156 20 dogs dog NNS cord-023095-4dannjjm 3156 21 and and CC cord-023095-4dannjjm 3156 22 other other JJ cord-023095-4dannjjm 3156 23 species specie NNS cord-023095-4dannjjm 3156 24 , , , cord-023095-4dannjjm 3156 25 we -PRON- PRP cord-023095-4dannjjm 3156 26 report report VBP cord-023095-4dannjjm 3156 27 here here RB cord-023095-4dannjjm 3156 28 the the DT cord-023095-4dannjjm 3156 29 clinical clinical JJ cord-023095-4dannjjm 3156 30 to to IN cord-023095-4dannjjm 3156 31 molecular molecular JJ cord-023095-4dannjjm 3156 32 investigations investigation NNS cord-023095-4dannjjm 3156 33 of of IN cord-023095-4dannjjm 3156 34 a a DT cord-023095-4dannjjm 3156 35 dog dog NN cord-023095-4dannjjm 3156 36 with with IN cord-023095-4dannjjm 3156 37 iron iron NN cord-023095-4dannjjm 3156 38 - - HYPH cord-023095-4dannjjm 3156 39 refractory refractory JJ cord-023095-4dannjjm 3156 40 iron iron NN cord-023095-4dannjjm 3156 41 deficiency deficiency NN cord-023095-4dannjjm 3156 42 anemia anemia NN cord-023095-4dannjjm 3156 43 ( ( -LRB- cord-023095-4dannjjm 3156 44 IRIDA IRIDA NNP cord-023095-4dannjjm 3156 45 ) ) -RRB- cord-023095-4dannjjm 3156 46 caused cause VBN cord-023095-4dannjjm 3156 47 by by IN cord-023095-4dannjjm 3156 48 a a DT cord-023095-4dannjjm 3156 49 matriptase-2 matriptase-2 NNP cord-023095-4dannjjm 3156 50 deficiency deficiency NN cord-023095-4dannjjm 3156 51 homologous homologous JJ cord-023095-4dannjjm 3156 52 to to IN cord-023095-4dannjjm 3156 53 a a DT cord-023095-4dannjjm 3156 54 recently recently RB cord-023095-4dannjjm 3156 55 described describe VBN cord-023095-4dannjjm 3156 56 autosomal autosomal JJ cord-023095-4dannjjm 3156 57 recessive recessive JJ cord-023095-4dannjjm 3156 58 disorder disorder NN cord-023095-4dannjjm 3156 59 in in IN cord-023095-4dannjjm 3156 60 humans human NNS cord-023095-4dannjjm 3156 61 . . . cord-023095-4dannjjm 3157 1 The the DT cord-023095-4dannjjm 3157 2 proband proband NN cord-023095-4dannjjm 3157 3 , , , cord-023095-4dannjjm 3157 4 a a DT cord-023095-4dannjjm 3157 5 spayed spay VBN cord-023095-4dannjjm 3157 6 female female JJ cord-023095-4dannjjm 3157 7 Cocker Cocker NNP cord-023095-4dannjjm 3157 8 Spaniel Spaniel NNP cord-023095-4dannjjm 3157 9 without without IN cord-023095-4dannjjm 3157 10 any any DT cord-023095-4dannjjm 3157 11 clinical clinical JJ cord-023095-4dannjjm 3157 12 signs sign NNS cord-023095-4dannjjm 3157 13 except except IN cord-023095-4dannjjm 3157 14 for for IN cord-023095-4dannjjm 3157 15 recent recent JJ cord-023095-4dannjjm 3157 16 occasional occasional JJ cord-023095-4dannjjm 3157 17 idiopathic idiopathic JJ cord-023095-4dannjjm 3157 18 seizures seizure NNS cord-023095-4dannjjm 3157 19 , , , cord-023095-4dannjjm 3157 20 exhibited exhibit VBD cord-023095-4dannjjm 3157 21 a a DT cord-023095-4dannjjm 3157 22 lifelong lifelong JJ cord-023095-4dannjjm 3157 23 history history NN cord-023095-4dannjjm 3157 24 of of IN cord-023095-4dannjjm 3157 25 microcytosis microcytosis NNP cord-023095-4dannjjm 3157 26 and and CC cord-023095-4dannjjm 3157 27 hypochromasia hypochromasia NNP cord-023095-4dannjjm 3157 28 but but CC cord-023095-4dannjjm 3157 29 not not RB cord-023095-4dannjjm 3157 30 anemia anemia NN cord-023095-4dannjjm 3157 31 . . . cord-023095-4dannjjm 3158 1 There there EX cord-023095-4dannjjm 3158 2 was be VBD cord-023095-4dannjjm 3158 3 no no DT cord-023095-4dannjjm 3158 4 evidence evidence NN cord-023095-4dannjjm 3158 5 of of IN cord-023095-4dannjjm 3158 6 any any DT cord-023095-4dannjjm 3158 7 blood blood NN cord-023095-4dannjjm 3158 8 loss loss NN cord-023095-4dannjjm 3158 9 and and CC cord-023095-4dannjjm 3158 10 the the DT cord-023095-4dannjjm 3158 11 dog dog NN cord-023095-4dannjjm 3158 12 was be VBD cord-023095-4dannjjm 3158 13 receiving receive VBG cord-023095-4dannjjm 3158 14 an an DT cord-023095-4dannjjm 3158 15 appropriate appropriate JJ cord-023095-4dannjjm 3158 16 meat meat NN cord-023095-4dannjjm 3158 17 - - HYPH cord-023095-4dannjjm 3158 18 based base VBN cord-023095-4dannjjm 3158 19 diet diet NN cord-023095-4dannjjm 3158 20 . . . cord-023095-4dannjjm 3159 1 Mean mean JJ cord-023095-4dannjjm 3159 2 values value NNS cord-023095-4dannjjm 3159 3 of of IN cord-023095-4dannjjm 3159 4 complete complete JJ cord-023095-4dannjjm 3159 5 blood blood NN cord-023095-4dannjjm 3159 6 cell cell NN cord-023095-4dannjjm 3159 7 counts count NNS cord-023095-4dannjjm 3159 8 , , , cord-023095-4dannjjm 3159 9 performed perform VBN cord-023095-4dannjjm 3159 10 from from IN cord-023095-4dannjjm 3159 11 0.5 0.5 CD cord-023095-4dannjjm 3159 12 - - SYM cord-023095-4dannjjm 3159 13 5 5 CD cord-023095-4dannjjm 3159 14 years year NNS cord-023095-4dannjjm 3159 15 of of IN cord-023095-4dannjjm 3159 16 age age NN cord-023095-4dannjjm 3159 17 , , , cord-023095-4dannjjm 3159 18 were be VBD cord-023095-4dannjjm 3159 19 : : : cord-023095-4dannjjm 3159 20 hematocrit hematocrit NN cord-023095-4dannjjm 3159 21 41 41 CD cord-023095-4dannjjm 3159 22 % % NN cord-023095-4dannjjm 3159 23 ( ( -LRB- cord-023095-4dannjjm 3159 24 normal normal JJ cord-023095-4dannjjm 3159 25 reference reference NN cord-023095-4dannjjm 3159 26 range range NN cord-023095-4dannjjm 3159 27 39 39 CD cord-023095-4dannjjm 3159 28 - - SYM cord-023095-4dannjjm 3159 29 56 56 CD cord-023095-4dannjjm 3159 30 ) ) -RRB- cord-023095-4dannjjm 3159 31 ; ; : cord-023095-4dannjjm 3159 32 RBC RBC NNP cord-023095-4dannjjm 3159 33 count count VBP cord-023095-4dannjjm 3159 34 9.6 9.6 CD cord-023095-4dannjjm 3159 35 Â â CD cord-023095-4dannjjm 3159 36 10 10 CD cord-023095-4dannjjm 3159 37 6 6 CD cord-023095-4dannjjm 3159 38 /mL /mL . cord-023095-4dannjjm 3160 1 ( ( -LRB- cord-023095-4dannjjm 3160 2 5.8 5.8 CD cord-023095-4dannjjm 3160 3 - - SYM cord-023095-4dannjjm 3160 4 8.5 8.5 CD cord-023095-4dannjjm 3160 5 x x SYM cord-023095-4dannjjm 3160 6 10 10 CD cord-023095-4dannjjm 3160 7 6 6 CD cord-023095-4dannjjm 3160 8 ) ) -RRB- cord-023095-4dannjjm 3160 9 ; ; : cord-023095-4dannjjm 3160 10 MCV MCV NNP cord-023095-4dannjjm 3160 11 43 43 CD cord-023095-4dannjjm 3160 12 fL fl CD cord-023095-4dannjjm 3161 1 ( ( -LRB- cord-023095-4dannjjm 3161 2 62 62 CD cord-023095-4dannjjm 3161 3 - - SYM cord-023095-4dannjjm 3161 4 72 72 CD cord-023095-4dannjjm 3161 5 ) ) -RRB- cord-023095-4dannjjm 3161 6 ; ; : cord-023095-4dannjjm 3161 7 MCHC MCHC NNP cord-023095-4dannjjm 3161 8 31 31 CD cord-023095-4dannjjm 3162 1 g g NNP cord-023095-4dannjjm 3162 2 / / SYM cord-023095-4dannjjm 3162 3 dL dl NN cord-023095-4dannjjm 3162 4 ( ( -LRB- cord-023095-4dannjjm 3162 5 33 33 CD cord-023095-4dannjjm 3162 6 - - SYM cord-023095-4dannjjm 3162 7 36 36 CD cord-023095-4dannjjm 3162 8 ) ) -RRB- cord-023095-4dannjjm 3162 9 . . . cord-023095-4dannjjm 3163 1 Serum serum NN cord-023095-4dannjjm 3163 2 iron iron NN cord-023095-4dannjjm 3163 3 parameters parameter NNS cord-023095-4dannjjm 3163 4 revealed reveal VBD cord-023095-4dannjjm 3163 5 severe severe JJ cord-023095-4dannjjm 3163 6 iron iron NN cord-023095-4dannjjm 3163 7 deficiency deficiency NN cord-023095-4dannjjm 3163 8 with with IN cord-023095-4dannjjm 3163 9 serum serum NN cord-023095-4dannjjm 3163 10 iron iron NN cord-023095-4dannjjm 3163 11 34 34 CD cord-023095-4dannjjm 3163 12 mg mg NNP cord-023095-4dannjjm 3163 13 / / SYM cord-023095-4dannjjm 3163 14 dL dl NN cord-023095-4dannjjm 3163 15 ( ( -LRB- cord-023095-4dannjjm 3163 16 88 88 CD cord-023095-4dannjjm 3163 17 - - SYM cord-023095-4dannjjm 3163 18 238 238 CD cord-023095-4dannjjm 3163 19 ) ) -RRB- cord-023095-4dannjjm 3163 20 ; ; : cord-023095-4dannjjm 3163 21 Total Total NNP cord-023095-4dannjjm 3163 22 Iron Iron NNP cord-023095-4dannjjm 3163 23 Binding Binding NNP cord-023095-4dannjjm 3163 24 Capacity Capacity NNP cord-023095-4dannjjm 3163 25 378 378 CD cord-023095-4dannjjm 3163 26 mg mg NNP cord-023095-4dannjjm 3163 27 / / SYM cord-023095-4dannjjm 3163 28 dL dl NN cord-023095-4dannjjm 3163 29 ( ( -LRB- cord-023095-4dannjjm 3163 30 246 246 CD cord-023095-4dannjjm 3163 31 - - SYM cord-023095-4dannjjm 3163 32 450 450 CD cord-023095-4dannjjm 3163 33 ) ) -RRB- cord-023095-4dannjjm 3163 34 ; ; : cord-023095-4dannjjm 3163 35 serum serum NN cord-023095-4dannjjm 3163 36 iron iron NN cord-023095-4dannjjm 3163 37 saturation saturation NN cord-023095-4dannjjm 3163 38 o o NN cord-023095-4dannjjm 3163 39 9 9 CD cord-023095-4dannjjm 3163 40 % % NN cord-023095-4dannjjm 3163 41 ( ( -LRB- cord-023095-4dannjjm 3163 42 15 15 CD cord-023095-4dannjjm 3163 43 - - SYM cord-023095-4dannjjm 3163 44 50 50 CD cord-023095-4dannjjm 3163 45 % % NN cord-023095-4dannjjm 3163 46 ) ) -RRB- cord-023095-4dannjjm 3163 47 , , , cord-023095-4dannjjm 3163 48 and and CC cord-023095-4dannjjm 3163 49 ferritin ferritin NN cord-023095-4dannjjm 3163 50 410 410 CD cord-023095-4dannjjm 3163 51 ng ng NNP cord-023095-4dannjjm 3163 52 / / SYM cord-023095-4dannjjm 3163 53 dL dl NN cord-023095-4dannjjm 3163 54 ( ( -LRB- cord-023095-4dannjjm 3163 55 80 80 CD cord-023095-4dannjjm 3163 56 - - SYM cord-023095-4dannjjm 3163 57 800 800 CD cord-023095-4dannjjm 3163 58 ) ) -RRB- cord-023095-4dannjjm 3163 59 . . . cord-023095-4dannjjm 3164 1 Prolonged prolonged JJ cord-023095-4dannjjm 3164 2 courses course NNS cord-023095-4dannjjm 3164 3 of of IN cord-023095-4dannjjm 3164 4 oral oral JJ cord-023095-4dannjjm 3164 5 ferrous ferrous JJ cord-023095-4dannjjm 3164 6 sulfate sulfate NN cord-023095-4dannjjm 3164 7 supplementation supplementation NN cord-023095-4dannjjm 3164 8 and and CC cord-023095-4dannjjm 3164 9 several several JJ cord-023095-4dannjjm 3164 10 short short JJ cord-023095-4dannjjm 3164 11 courses course NNS cord-023095-4dannjjm 3164 12 of of IN cord-023095-4dannjjm 3164 13 intramuscular intramuscular JJ cord-023095-4dannjjm 3164 14 ( ( -LRB- cord-023095-4dannjjm 3164 15 Dextran dextran NN cord-023095-4dannjjm 3164 16 ) ) -RRB- cord-023095-4dannjjm 3164 17 injections injection NNS cord-023095-4dannjjm 3164 18 and and CC cord-023095-4dannjjm 3164 19 intravenous intravenous JJ cord-023095-4dannjjm 3164 20 iron iron NN cord-023095-4dannjjm 3164 21 infusions infusion NNS cord-023095-4dannjjm 3164 22 did do VBD cord-023095-4dannjjm 3164 23 not not RB cord-023095-4dannjjm 3164 24 result result VB cord-023095-4dannjjm 3164 25 in in IN cord-023095-4dannjjm 3164 26 improvement improvement NN cord-023095-4dannjjm 3164 27 of of IN cord-023095-4dannjjm 3164 28 any any DT cord-023095-4dannjjm 3164 29 red red JJ cord-023095-4dannjjm 3164 30 cell cell NN cord-023095-4dannjjm 3164 31 or or CC cord-023095-4dannjjm 3164 32 serum serum NN cord-023095-4dannjjm 3164 33 iron iron NN cord-023095-4dannjjm 3164 34 parameters parameter NNS cord-023095-4dannjjm 3164 35 . . . cord-023095-4dannjjm 3165 1 However however RB cord-023095-4dannjjm 3165 2 , , , cord-023095-4dannjjm 3165 3 this this DT cord-023095-4dannjjm 3165 4 dog dog NN cord-023095-4dannjjm 3165 5 was be VBD cord-023095-4dannjjm 3165 6 never never RB cord-023095-4dannjjm 3165 7 anemic anemic JJ cord-023095-4dannjjm 3165 8 and and CC cord-023095-4dannjjm 3165 9 the the DT cord-023095-4dannjjm 3165 10 partial partial JJ cord-023095-4dannjjm 3165 11 seizures seizure NNS cord-023095-4dannjjm 3165 12 could could MD cord-023095-4dannjjm 3165 13 not not RB cord-023095-4dannjjm 3165 14 be be VB cord-023095-4dannjjm 3165 15 directly directly RB cord-023095-4dannjjm 3165 16 related relate VBN cord-023095-4dannjjm 3165 17 to to IN cord-023095-4dannjjm 3165 18 the the DT cord-023095-4dannjjm 3165 19 iron iron NN cord-023095-4dannjjm 3165 20 deficiency deficiency NN cord-023095-4dannjjm 3165 21 status status NN cord-023095-4dannjjm 3165 22 . . . cord-023095-4dannjjm 3166 1 No no DT cord-023095-4dannjjm 3166 2 family family NN cord-023095-4dannjjm 3166 3 members member NNS cord-023095-4dannjjm 3166 4 were be VBD cord-023095-4dannjjm 3166 5 available available JJ cord-023095-4dannjjm 3166 6 for for IN cord-023095-4dannjjm 3166 7 further further JJ cord-023095-4dannjjm 3166 8 studies study NNS cord-023095-4dannjjm 3166 9 . . . cord-023095-4dannjjm 3167 1 Genomic genomic JJ cord-023095-4dannjjm 3167 2 DNA dna NN cord-023095-4dannjjm 3167 3 was be VBD cord-023095-4dannjjm 3167 4 extracted extract VBN cord-023095-4dannjjm 3167 5 from from IN cord-023095-4dannjjm 3167 6 the the DT cord-023095-4dannjjm 3167 7 proband proband NN cord-023095-4dannjjm 3167 8 's 's POS cord-023095-4dannjjm 3167 9 EDTA EDTA NNP cord-023095-4dannjjm 3167 10 blood blood NN cord-023095-4dannjjm 3167 11 and and CC cord-023095-4dannjjm 3167 12 the the DT cord-023095-4dannjjm 3167 13 exons exon NNS cord-023095-4dannjjm 3167 14 of of IN cord-023095-4dannjjm 3167 15 the the DT cord-023095-4dannjjm 3167 16 TMPRSS6 TMPRSS6 NNP cord-023095-4dannjjm 3167 17 gene gene NN cord-023095-4dannjjm 3167 18 were be VBD cord-023095-4dannjjm 3167 19 amplified amplify VBN cord-023095-4dannjjm 3167 20 with with IN cord-023095-4dannjjm 3167 21 flanking flank VBG cord-023095-4dannjjm 3167 22 primers primer NNS cord-023095-4dannjjm 3167 23 and and CC cord-023095-4dannjjm 3167 24 then then RB cord-023095-4dannjjm 3167 25 sequenced sequence VBN cord-023095-4dannjjm 3167 26 . . . cord-023095-4dannjjm 3168 1 In in IN cord-023095-4dannjjm 3168 2 comparison comparison NN cord-023095-4dannjjm 3168 3 to to IN cord-023095-4dannjjm 3168 4 the the DT cord-023095-4dannjjm 3168 5 normal normal JJ cord-023095-4dannjjm 3168 6 canine canine JJ cord-023095-4dannjjm 3168 7 TMPRSS6 tmprss6 XX cord-023095-4dannjjm 3168 8 sequence sequence NN cord-023095-4dannjjm 3168 9 and and CC cord-023095-4dannjjm 3168 10 that that DT cord-023095-4dannjjm 3168 11 of of IN cord-023095-4dannjjm 3168 12 a a DT cord-023095-4dannjjm 3168 13 sequenced sequence VBN cord-023095-4dannjjm 3168 14 control control NN cord-023095-4dannjjm 3168 15 dog dog NN cord-023095-4dannjjm 3168 16 we -PRON- PRP cord-023095-4dannjjm 3168 17 found find VBD cord-023095-4dannjjm 3168 18 a a DT cord-023095-4dannjjm 3168 19 homozygous homozygous JJ cord-023095-4dannjjm 3168 20 missense missense NN cord-023095-4dannjjm 3168 21 muation muation NN cord-023095-4dannjjm 3168 22 , , , cord-023095-4dannjjm 3168 23 R723H R723H NNP cord-023095-4dannjjm 3168 24 , , , cord-023095-4dannjjm 3168 25 toward toward IN cord-023095-4dannjjm 3168 26 the the DT cord-023095-4dannjjm 3168 27 C c NN cord-023095-4dannjjm 3168 28 - - HYPH cord-023095-4dannjjm 3168 29 terminal terminal JJ cord-023095-4dannjjm 3168 30 end end NN cord-023095-4dannjjm 3168 31 of of IN cord-023095-4dannjjm 3168 32 the the DT cord-023095-4dannjjm 3168 33 protein protein NN cord-023095-4dannjjm 3168 34 in in IN cord-023095-4dannjjm 3168 35 the the DT cord-023095-4dannjjm 3168 36 proband proband NN cord-023095-4dannjjm 3168 37 's 's POS cord-023095-4dannjjm 3168 38 gene gene NN cord-023095-4dannjjm 3168 39 . . . cord-023095-4dannjjm 3169 1 In in IN cord-023095-4dannjjm 3169 2 conclusion conclusion NN cord-023095-4dannjjm 3169 3 , , , cord-023095-4dannjjm 3169 4 the the DT cord-023095-4dannjjm 3169 5 severe severe JJ cord-023095-4dannjjm 3169 6 microcytosis microcytosis NN cord-023095-4dannjjm 3169 7 and and CC cord-023095-4dannjjm 3169 8 hypochromasia hypochromasia NNP cord-023095-4dannjjm 3169 9 , , , cord-023095-4dannjjm 3169 10 low low JJ cord-023095-4dannjjm 3169 11 serum serum NN cord-023095-4dannjjm 3169 12 iron iron NN cord-023095-4dannjjm 3169 13 parameters parameter NNS cord-023095-4dannjjm 3169 14 and and CC cord-023095-4dannjjm 3169 15 lack lack NN cord-023095-4dannjjm 3169 16 of of IN cord-023095-4dannjjm 3169 17 a a DT cord-023095-4dannjjm 3169 18 response response NN cord-023095-4dannjjm 3169 19 to to IN cord-023095-4dannjjm 3169 20 oral oral JJ cord-023095-4dannjjm 3169 21 and and CC cord-023095-4dannjjm 3169 22 parenteral parenteral JJ cord-023095-4dannjjm 3169 23 iron iron NN cord-023095-4dannjjm 3169 24 therapy therapy NN cord-023095-4dannjjm 3169 25 led lead VBD cord-023095-4dannjjm 3169 26 to to IN cord-023095-4dannjjm 3169 27 the the DT cord-023095-4dannjjm 3169 28 diagnosis diagnosis NN cord-023095-4dannjjm 3169 29 of of IN cord-023095-4dannjjm 3169 30 IRIDA IRIDA NNP cord-023095-4dannjjm 3169 31 . . . cord-023095-4dannjjm 3170 1 The the DT cord-023095-4dannjjm 3170 2 missense missense NN cord-023095-4dannjjm 3170 3 mutation mutation NN cord-023095-4dannjjm 3170 4 in in IN cord-023095-4dannjjm 3170 5 the the DT cord-023095-4dannjjm 3170 6 matriptase-2 matriptase-2 NNP cord-023095-4dannjjm 3170 7 at at IN cord-023095-4dannjjm 3170 8 position position NN cord-023095-4dannjjm 3170 9 723 723 CD cord-023095-4dannjjm 3170 10 from from IN cord-023095-4dannjjm 3170 11 an an DT cord-023095-4dannjjm 3170 12 arginine arginine NN cord-023095-4dannjjm 3170 13 , , , cord-023095-4dannjjm 3170 14 which which WDT cord-023095-4dannjjm 3170 15 is be VBZ cord-023095-4dannjjm 3170 16 conserved conserve VBN cord-023095-4dannjjm 3170 17 across across IN cord-023095-4dannjjm 3170 18 all all DT cord-023095-4dannjjm 3170 19 species specie NNS cord-023095-4dannjjm 3170 20 currently currently RB cord-023095-4dannjjm 3170 21 deposited deposit VBN cord-023095-4dannjjm 3170 22 in in IN cord-023095-4dannjjm 3170 23 the the DT cord-023095-4dannjjm 3170 24 Genbank Genbank NNP cord-023095-4dannjjm 3170 25 , , , cord-023095-4dannjjm 3170 26 to to IN cord-023095-4dannjjm 3170 27 a a DT cord-023095-4dannjjm 3170 28 histidine histidine NN cord-023095-4dannjjm 3170 29 is be VBZ cord-023095-4dannjjm 3170 30 likely likely RB cord-023095-4dannjjm 3170 31 the the DT cord-023095-4dannjjm 3170 32 disease disease NN cord-023095-4dannjjm 3170 33 - - HYPH cord-023095-4dannjjm 3170 34 causing cause VBG cord-023095-4dannjjm 3170 35 mutation mutation NN cord-023095-4dannjjm 3170 36 . . . cord-023095-4dannjjm 3171 1 This this DT cord-023095-4dannjjm 3171 2 is be VBZ cord-023095-4dannjjm 3171 3 the the DT cord-023095-4dannjjm 3171 4 first first JJ cord-023095-4dannjjm 3171 5 report report NN cord-023095-4dannjjm 3171 6 of of IN cord-023095-4dannjjm 3171 7 an an DT cord-023095-4dannjjm 3171 8 IRIDA IRIDA NNP cord-023095-4dannjjm 3171 9 in in IN cord-023095-4dannjjm 3171 10 the the DT cord-023095-4dannjjm 3171 11 dog dog NN cord-023095-4dannjjm 3171 12 with with IN cord-023095-4dannjjm 3171 13 features feature VBZ cord-023095-4dannjjm 3171 14 very very RB cord-023095-4dannjjm 3171 15 similar similar JJ cord-023095-4dannjjm 3171 16 to to IN cord-023095-4dannjjm 3171 17 those those DT cord-023095-4dannjjm 3171 18 observed observe VBN cord-023095-4dannjjm 3171 19 in in IN cord-023095-4dannjjm 3171 20 humans human NNS cord-023095-4dannjjm 3171 21 . . . cord-023095-4dannjjm 3172 1 Dogs dog NNS cord-023095-4dannjjm 3172 2 with with IN cord-023095-4dannjjm 3172 3 naturally naturally RB cord-023095-4dannjjm 3172 4 - - HYPH cord-023095-4dannjjm 3172 5 occurring occur VBG cord-023095-4dannjjm 3172 6 IRIDA IRIDA NNP cord-023095-4dannjjm 3172 7 may may MD cord-023095-4dannjjm 3172 8 be be VB cord-023095-4dannjjm 3172 9 helpful helpful JJ cord-023095-4dannjjm 3172 10 in in IN cord-023095-4dannjjm 3172 11 developing develop VBG cord-023095-4dannjjm 3172 12 and and CC cord-023095-4dannjjm 3172 13 assessing assess VBG cord-023095-4dannjjm 3172 14 novel novel JJ cord-023095-4dannjjm 3172 15 therapies therapy NNS cord-023095-4dannjjm 3172 16 . . . cord-023095-4dannjjm 3173 1 Accidental accidental JJ cord-023095-4dannjjm 3173 2 ingestion ingestion NN cord-023095-4dannjjm 3173 3 of of IN cord-023095-4dannjjm 3173 4 copper copper NN cord-023095-4dannjjm 3173 5 - - HYPH cord-023095-4dannjjm 3173 6 coated coat VBN cord-023095-4dannjjm 3173 7 zinc zinc NN cord-023095-4dannjjm 3173 8 pennies penny NNS cord-023095-4dannjjm 3173 9 minted mint VBN cord-023095-4dannjjm 3173 10 after after IN cord-023095-4dannjjm 3173 11 1982 1982 CD cord-023095-4dannjjm 3173 12 is be VBZ cord-023095-4dannjjm 3173 13 the the DT cord-023095-4dannjjm 3173 14 most most RBS cord-023095-4dannjjm 3173 15 common common JJ cord-023095-4dannjjm 3173 16 causes cause NNS cord-023095-4dannjjm 3173 17 of of IN cord-023095-4dannjjm 3173 18 zinc zinc NN cord-023095-4dannjjm 3173 19 toxicity toxicity NN cord-023095-4dannjjm 3173 20 anemia anemia NN cord-023095-4dannjjm 3173 21 in in IN cord-023095-4dannjjm 3173 22 the the DT cord-023095-4dannjjm 3173 23 dog dog NN cord-023095-4dannjjm 3173 24 . . . cord-023095-4dannjjm 3174 1 Zinc zinc NN cord-023095-4dannjjm 3174 2 toxicity toxicity NN cord-023095-4dannjjm 3174 3 anemia anemia NN cord-023095-4dannjjm 3174 4 may may MD cord-023095-4dannjjm 3174 5 also also RB cord-023095-4dannjjm 3174 6 be be VB cord-023095-4dannjjm 3174 7 seen see VBN cord-023095-4dannjjm 3174 8 with with IN cord-023095-4dannjjm 3174 9 ingestion ingestion NN cord-023095-4dannjjm 3174 10 of of IN cord-023095-4dannjjm 3174 11 zinc zinc NN cord-023095-4dannjjm 3174 12 from from IN cord-023095-4dannjjm 3174 13 other other JJ cord-023095-4dannjjm 3174 14 sources source NNS cord-023095-4dannjjm 3174 15 as as IN cord-023095-4dannjjm 3174 16 ingestion ingestion NN cord-023095-4dannjjm 3174 17 of of IN cord-023095-4dannjjm 3174 18 metallic metallic JJ cord-023095-4dannjjm 3174 19 foreign foreign JJ cord-023095-4dannjjm 3174 20 material material NN cord-023095-4dannjjm 3174 21 other other JJ cord-023095-4dannjjm 3174 22 than than IN cord-023095-4dannjjm 3174 23 pennies penny NNS cord-023095-4dannjjm 3174 24 , , , cord-023095-4dannjjm 3174 25 medicines medicine NNS cord-023095-4dannjjm 3174 26 containing contain VBG cord-023095-4dannjjm 3174 27 zinc zinc NN cord-023095-4dannjjm 3174 28 , , , cord-023095-4dannjjm 3174 29 and and CC cord-023095-4dannjjm 3174 30 zinc zinc NN cord-023095-4dannjjm 3174 31 supplements supplement NNS cord-023095-4dannjjm 3174 32 . . . cord-023095-4dannjjm 3175 1 The the DT cord-023095-4dannjjm 3175 2 purpose purpose NN cord-023095-4dannjjm 3175 3 of of IN cord-023095-4dannjjm 3175 4 this this DT cord-023095-4dannjjm 3175 5 study study NN cord-023095-4dannjjm 3175 6 was be VBD cord-023095-4dannjjm 3175 7 to to TO cord-023095-4dannjjm 3175 8 determine determine VB cord-023095-4dannjjm 3175 9 if if IN cord-023095-4dannjjm 3175 10 there there EX cord-023095-4dannjjm 3175 11 is be VBZ cord-023095-4dannjjm 3175 12 a a DT cord-023095-4dannjjm 3175 13 weight weight NN cord-023095-4dannjjm 3175 14 below below IN cord-023095-4dannjjm 3175 15 which which WDT cord-023095-4dannjjm 3175 16 dogs dog NNS cord-023095-4dannjjm 3175 17 are be VBP cord-023095-4dannjjm 3175 18 more more RBR cord-023095-4dannjjm 3175 19 susceptible susceptible JJ cord-023095-4dannjjm 3175 20 to to IN cord-023095-4dannjjm 3175 21 zinc zinc NN cord-023095-4dannjjm 3175 22 toxicity toxicity NN cord-023095-4dannjjm 3175 23 anemia anemia NN cord-023095-4dannjjm 3175 24 secondary secondary JJ cord-023095-4dannjjm 3175 25 to to IN cord-023095-4dannjjm 3175 26 metallic metallic JJ cord-023095-4dannjjm 3175 27 foreign foreign JJ cord-023095-4dannjjm 3175 28 body body NN cord-023095-4dannjjm 3175 29 ingestion ingestion NN cord-023095-4dannjjm 3175 30 . . . cord-023095-4dannjjm 3176 1 Records record NNS cord-023095-4dannjjm 3176 2 of of IN cord-023095-4dannjjm 3176 3 dogs dog NNS cord-023095-4dannjjm 3176 4 presented present VBN cord-023095-4dannjjm 3176 5 to to IN cord-023095-4dannjjm 3176 6 the the DT cord-023095-4dannjjm 3176 7 Internal Internal NNP cord-023095-4dannjjm 3176 8 Medicine Medicine NNP cord-023095-4dannjjm 3176 9 service service NN cord-023095-4dannjjm 3176 10 at at IN cord-023095-4dannjjm 3176 11 the the DT cord-023095-4dannjjm 3176 12 Veterinary Veterinary NNP cord-023095-4dannjjm 3176 13 Medical Medical NNP cord-023095-4dannjjm 3176 14 Center Center NNP cord-023095-4dannjjm 3176 15 of of IN cord-023095-4dannjjm 3176 16 Long Long NNP cord-023095-4dannjjm 3176 17 Island Island NNP cord-023095-4dannjjm 3176 18 for for IN cord-023095-4dannjjm 3176 19 metallic metallic JJ cord-023095-4dannjjm 3176 20 foreign foreign JJ cord-023095-4dannjjm 3176 21 body body NN cord-023095-4dannjjm 3176 22 ingestion ingestion NN cord-023095-4dannjjm 3176 23 were be VBD cord-023095-4dannjjm 3176 24 reviewed review VBN cord-023095-4dannjjm 3176 25 for for IN cord-023095-4dannjjm 3176 26 signalment signalment JJ cord-023095-4dannjjm 3176 27 , , , cord-023095-4dannjjm 3176 28 weight weight NN cord-023095-4dannjjm 3176 29 , , , cord-023095-4dannjjm 3176 30 presenting present VBG cord-023095-4dannjjm 3176 31 PCV pcv NN cord-023095-4dannjjm 3176 32 , , , cord-023095-4dannjjm 3176 33 and and CC cord-023095-4dannjjm 3176 34 type type NN cord-023095-4dannjjm 3176 35 of of IN cord-023095-4dannjjm 3176 36 metallic metallic JJ cord-023095-4dannjjm 3176 37 foreign foreign JJ cord-023095-4dannjjm 3176 38 body body NN cord-023095-4dannjjm 3176 39 ingested ingest VBN cord-023095-4dannjjm 3176 40 . . . cord-023095-4dannjjm 3177 1 Eighteen eighteen CD cord-023095-4dannjjm 3177 2 dogs dog NNS cord-023095-4dannjjm 3177 3 met meet VBD cord-023095-4dannjjm 3177 4 the the DT cord-023095-4dannjjm 3177 5 inclusion inclusion NN cord-023095-4dannjjm 3177 6 criteria criterion NNS cord-023095-4dannjjm 3177 7 and and CC cord-023095-4dannjjm 3177 8 were be VBD cord-023095-4dannjjm 3177 9 compared compare VBN cord-023095-4dannjjm 3177 10 . . . cord-023095-4dannjjm 3178 1 Of of IN cord-023095-4dannjjm 3178 2 the the DT cord-023095-4dannjjm 3178 3 18 18 CD cord-023095-4dannjjm 3178 4 dogs dog NNS cord-023095-4dannjjm 3178 5 , , , cord-023095-4dannjjm 3178 6 there there EX cord-023095-4dannjjm 3178 7 were be VBD cord-023095-4dannjjm 3178 8 15 15 CD cord-023095-4dannjjm 3178 9 cases case NNS cord-023095-4dannjjm 3178 10 of of IN cord-023095-4dannjjm 3178 11 coin coin NN cord-023095-4dannjjm 3178 12 ingestion ingestion NN cord-023095-4dannjjm 3178 13 ( ( -LRB- cord-023095-4dannjjm 3178 14 83 83 CD cord-023095-4dannjjm 3178 15 % % NN cord-023095-4dannjjm 3178 16 ) ) -RRB- cord-023095-4dannjjm 3178 17 , , , cord-023095-4dannjjm 3178 18 with with IN cord-023095-4dannjjm 3178 19 11 11 CD cord-023095-4dannjjm 3178 20 ( ( -LRB- cord-023095-4dannjjm 3178 21 73 73 CD cord-023095-4dannjjm 3178 22 % % NN cord-023095-4dannjjm 3178 23 ) ) -RRB- cord-023095-4dannjjm 3178 24 involving involve VBG cord-023095-4dannjjm 3178 25 ingestion ingestion NN cord-023095-4dannjjm 3178 26 of of IN cord-023095-4dannjjm 3178 27 1 1 CD cord-023095-4dannjjm 3178 28 or or CC cord-023095-4dannjjm 3178 29 more more JJR cord-023095-4dannjjm 3178 30 pennies penny NNS cord-023095-4dannjjm 3178 31 . . . cord-023095-4dannjjm 3179 1 The the DT cord-023095-4dannjjm 3179 2 other other JJ cord-023095-4dannjjm 3179 3 3 3 CD cord-023095-4dannjjm 3179 4 cases case NNS cord-023095-4dannjjm 3179 5 involved involve VBD cord-023095-4dannjjm 3179 6 ingestion ingestion NN cord-023095-4dannjjm 3179 7 of of IN cord-023095-4dannjjm 3179 8 a a DT cord-023095-4dannjjm 3179 9 metallic metallic JJ cord-023095-4dannjjm 3179 10 object object NN cord-023095-4dannjjm 3179 11 ( ( -LRB- cord-023095-4dannjjm 3179 12 1 1 CD cord-023095-4dannjjm 3179 13 ) ) -RRB- cord-023095-4dannjjm 3179 14 , , , cord-023095-4dannjjm 3179 15 decorative decorative JJ cord-023095-4dannjjm 3179 16 garland garland NN cord-023095-4dannjjm 3179 17 ( ( -LRB- cord-023095-4dannjjm 3179 18 1 1 CD cord-023095-4dannjjm 3179 19 ) ) -RRB- cord-023095-4dannjjm 3179 20 , , , cord-023095-4dannjjm 3179 21 and and CC cord-023095-4dannjjm 3179 22 BB BB NNP cord-023095-4dannjjm 3179 23 pellets pellet NNS cord-023095-4dannjjm 3180 1 ( ( -LRB- cord-023095-4dannjjm 3180 2 1).Of 1).of CD cord-023095-4dannjjm 3180 3 the the DT cord-023095-4dannjjm 3180 4 14 14 CD cord-023095-4dannjjm 3180 5 dogs dog NNS cord-023095-4dannjjm 3180 6 exposed expose VBN cord-023095-4dannjjm 3180 7 to to IN cord-023095-4dannjjm 3180 8 zinc zinc NN cord-023095-4dannjjm 3180 9 , , , cord-023095-4dannjjm 3180 10 13 13 CD cord-023095-4dannjjm 3180 11 ( ( -LRB- cord-023095-4dannjjm 3180 12 93 93 CD cord-023095-4dannjjm 3180 13 % % NN cord-023095-4dannjjm 3180 14 ) ) -RRB- cord-023095-4dannjjm 3180 15 were be VBD cord-023095-4dannjjm 3180 16 less less JJR cord-023095-4dannjjm 3180 17 than than IN cord-023095-4dannjjm 3180 18 27 27 CD cord-023095-4dannjjm 3180 19 pounds pound NNS cord-023095-4dannjjm 3180 20 ( ( -LRB- cord-023095-4dannjjm 3180 21 12.3 12.3 CD cord-023095-4dannjjm 3180 22 kgs kgs NNP cord-023095-4dannjjm 3180 23 ) ) -RRB- cord-023095-4dannjjm 3180 24 . . . cord-023095-4dannjjm 3181 1 Of of IN cord-023095-4dannjjm 3181 2 those those DT cord-023095-4dannjjm 3181 3 13 13 CD cord-023095-4dannjjm 3181 4 cases case NNS cord-023095-4dannjjm 3181 5 11 11 CD cord-023095-4dannjjm 3181 6 ( ( -LRB- cord-023095-4dannjjm 3181 7 85 85 CD cord-023095-4dannjjm 3181 8 % % NN cord-023095-4dannjjm 3181 9 ) ) -RRB- cord-023095-4dannjjm 3181 10 had have VBD cord-023095-4dannjjm 3181 11 ingested ingest VBN cord-023095-4dannjjm 3181 12 one one CD cord-023095-4dannjjm 3181 13 or or CC cord-023095-4dannjjm 3181 14 more more JJR cord-023095-4dannjjm 3181 15 pennies penny NNS cord-023095-4dannjjm 3181 16 . . . cord-023095-4dannjjm 3182 1 Eleven eleven CD cord-023095-4dannjjm 3182 2 out out IN cord-023095-4dannjjm 3182 3 of of IN cord-023095-4dannjjm 3182 4 the the DT cord-023095-4dannjjm 3182 5 14 14 CD cord-023095-4dannjjm 3182 6 ( ( -LRB- cord-023095-4dannjjm 3182 7 79 79 CD cord-023095-4dannjjm 3182 8 % % NN cord-023095-4dannjjm 3182 9 ) ) -RRB- cord-023095-4dannjjm 3183 1 zinc zinc NN cord-023095-4dannjjm 3183 2 exposure exposure NN cord-023095-4dannjjm 3183 3 dogs dog NNS cord-023095-4dannjjm 3183 4 were be VBD cord-023095-4dannjjm 3183 5 anemic anemic JJ cord-023095-4dannjjm 3183 6 at at IN cord-023095-4dannjjm 3183 7 presentation presentation NN cord-023095-4dannjjm 3183 8 . . . cord-023095-4dannjjm 3184 1 The the DT cord-023095-4dannjjm 3184 2 average average JJ cord-023095-4dannjjm 3184 3 weight weight NN cord-023095-4dannjjm 3184 4 of of IN cord-023095-4dannjjm 3184 5 the the DT cord-023095-4dannjjm 3184 6 11 11 CD cord-023095-4dannjjm 3184 7 dogs dog NNS cord-023095-4dannjjm 3184 8 was be VBD cord-023095-4dannjjm 3184 9 17.5 17.5 CD cord-023095-4dannjjm 3184 10 pounds pound NNS cord-023095-4dannjjm 3184 11 ( ( -LRB- cord-023095-4dannjjm 3184 12 8 8 CD cord-023095-4dannjjm 3184 13 kg kg NN cord-023095-4dannjjm 3184 14 ) ) -RRB- cord-023095-4dannjjm 3184 15 . . . cord-023095-4dannjjm 3185 1 This this DT cord-023095-4dannjjm 3185 2 study study NN cord-023095-4dannjjm 3185 3 showed show VBD cord-023095-4dannjjm 3185 4 that that IN cord-023095-4dannjjm 3185 5 dogs dog NNS cord-023095-4dannjjm 3185 6 less less JJR cord-023095-4dannjjm 3185 7 than than IN cord-023095-4dannjjm 3185 8 27 27 CD cord-023095-4dannjjm 3185 9 pounds pound NNS cord-023095-4dannjjm 3185 10 appear appear VBP cord-023095-4dannjjm 3185 11 to to TO cord-023095-4dannjjm 3185 12 be be VB cord-023095-4dannjjm 3185 13 more more RBR cord-023095-4dannjjm 3185 14 susceptible susceptible JJ cord-023095-4dannjjm 3185 15 to to IN cord-023095-4dannjjm 3185 16 developing develop VBG cord-023095-4dannjjm 3185 17 anemia anemia NN cord-023095-4dannjjm 3185 18 secondary secondary JJ cord-023095-4dannjjm 3185 19 to to IN cord-023095-4dannjjm 3185 20 zinc zinc NN cord-023095-4dannjjm 3185 21 toxicosis toxicosis NN cord-023095-4dannjjm 3185 22 , , , cord-023095-4dannjjm 3185 23 with with IN cord-023095-4dannjjm 3185 24 the the DT cord-023095-4dannjjm 3185 25 majority majority NN cord-023095-4dannjjm 3185 26 of of IN cord-023095-4dannjjm 3185 27 cases case NNS cord-023095-4dannjjm 3185 28 due due JJ cord-023095-4dannjjm 3185 29 to to IN cord-023095-4dannjjm 3185 30 ingestion ingestion NN cord-023095-4dannjjm 3185 31 of of IN cord-023095-4dannjjm 3185 32 pennies penny NNS cord-023095-4dannjjm 3185 33 minted mint VBN cord-023095-4dannjjm 3185 34 after after IN cord-023095-4dannjjm 3185 35 1982 1982 CD cord-023095-4dannjjm 3185 36 . . . cord-023095-4dannjjm 3186 1 Zinc zinc NN cord-023095-4dannjjm 3186 2 toxicity toxicity NN cord-023095-4dannjjm 3186 3 anemia anemia NN cord-023095-4dannjjm 3186 4 secondary secondary JJ cord-023095-4dannjjm 3186 5 to to TO cord-023095-4dannjjm 3186 6 penny penny NN cord-023095-4dannjjm 3186 7 ingestion ingestion NN cord-023095-4dannjjm 3186 8 is be VBZ cord-023095-4dannjjm 3186 9 more more RBR cord-023095-4dannjjm 3186 10 commonly commonly RB cord-023095-4dannjjm 3186 11 seen see VBN cord-023095-4dannjjm 3186 12 in in IN cord-023095-4dannjjm 3186 13 small small JJ cord-023095-4dannjjm 3186 14 dogs dog NNS cord-023095-4dannjjm 3186 15 . . . cord-023095-4dannjjm 3187 1 We -PRON- PRP cord-023095-4dannjjm 3187 2 suspect suspect VBP cord-023095-4dannjjm 3187 3 larger large JJR cord-023095-4dannjjm 3187 4 dogs dog NNS cord-023095-4dannjjm 3187 5 are be VBP cord-023095-4dannjjm 3187 6 able able JJ cord-023095-4dannjjm 3187 7 to to TO cord-023095-4dannjjm 3187 8 pass pass VB cord-023095-4dannjjm 3187 9 pennies penny NNS cord-023095-4dannjjm 3187 10 through through IN cord-023095-4dannjjm 3187 11 the the DT cord-023095-4dannjjm 3187 12 pyloric pyloric JJ cord-023095-4dannjjm 3187 13 sphincter sphincter NN cord-023095-4dannjjm 3187 14 and and CC cord-023095-4dannjjm 3187 15 thus thus RB cord-023095-4dannjjm 3187 16 not not RB cord-023095-4dannjjm 3187 17 develop develop VB cord-023095-4dannjjm 3187 18 clinical clinical JJ cord-023095-4dannjjm 3187 19 signs sign NNS cord-023095-4dannjjm 3187 20 . . . cord-023095-4dannjjm 3188 1 Although although IN cord-023095-4dannjjm 3188 2 thrombocytopenia thrombocytopenia NN cord-023095-4dannjjm 3188 3 is be VBZ cord-023095-4dannjjm 3188 4 common common JJ cord-023095-4dannjjm 3188 5 in in IN cord-023095-4dannjjm 3188 6 hospitalized hospitalize VBN cord-023095-4dannjjm 3188 7 dogs dog NNS cord-023095-4dannjjm 3188 8 , , , cord-023095-4dannjjm 3188 9 canine canine JJ cord-023095-4dannjjm 3188 10 cryopreserved cryopreserved JJ cord-023095-4dannjjm 3188 11 platelet platelet NN cord-023095-4dannjjm 3188 12 concentrate concentrate NN cord-023095-4dannjjm 3188 13 ( ( -LRB- cord-023095-4dannjjm 3188 14 PC pc NN cord-023095-4dannjjm 3188 15 ) ) -RRB- cord-023095-4dannjjm 3188 16 is be VBZ cord-023095-4dannjjm 3188 17 used use VBN cord-023095-4dannjjm 3188 18 infrequently infrequently RB cord-023095-4dannjjm 3188 19 . . . cord-023095-4dannjjm 3189 1 Data datum NNS cord-023095-4dannjjm 3189 2 suggest suggest VBP cord-023095-4dannjjm 3189 3 in in IN cord-023095-4dannjjm 3189 4 vitro vitro FW cord-023095-4dannjjm 3189 5 efficacy efficacy NN cord-023095-4dannjjm 3189 6 of of IN cord-023095-4dannjjm 3189 7 PC pc NN cord-023095-4dannjjm 3189 8 and and CC cord-023095-4dannjjm 3189 9 when when WRB cord-023095-4dannjjm 3189 10 administered administer VBN cord-023095-4dannjjm 3189 11 to to TO cord-023095-4dannjjm 3189 12 research research VB cord-023095-4dannjjm 3189 13 dogs dog NNS cord-023095-4dannjjm 3189 14 , , , cord-023095-4dannjjm 3189 15 but but CC cord-023095-4dannjjm 3189 16 efficacy efficacy NN cord-023095-4dannjjm 3189 17 is be VBZ cord-023095-4dannjjm 3189 18 unknown unknown JJ cord-023095-4dannjjm 3189 19 in in IN cord-023095-4dannjjm 3189 20 clinical clinical JJ cord-023095-4dannjjm 3189 21 patients patient NNS cord-023095-4dannjjm 3189 22 . . . cord-023095-4dannjjm 3190 1 Study study NN cord-023095-4dannjjm 3190 2 objectives objective NNS cord-023095-4dannjjm 3190 3 were be VBD cord-023095-4dannjjm 3190 4 to to TO cord-023095-4dannjjm 3190 5 determine determine VB cord-023095-4dannjjm 3190 6 clinical clinical JJ cord-023095-4dannjjm 3190 7 characteristics characteristic NNS cord-023095-4dannjjm 3190 8 of of IN cord-023095-4dannjjm 3190 9 dogs dog NNS cord-023095-4dannjjm 3190 10 receiving receive VBG cord-023095-4dannjjm 3190 11 PC pc NN cord-023095-4dannjjm 3190 12 as as RB cord-023095-4dannjjm 3190 13 well well RB cord-023095-4dannjjm 3190 14 as as IN cord-023095-4dannjjm 3190 15 safety safety NN cord-023095-4dannjjm 3190 16 and and CC cord-023095-4dannjjm 3190 17 efficacy efficacy NN cord-023095-4dannjjm 3190 18 of of IN cord-023095-4dannjjm 3190 19 PC pc NN cord-023095-4dannjjm 3190 20 in in IN cord-023095-4dannjjm 3190 21 thrombocytopenic thrombocytopenic JJ cord-023095-4dannjjm 3190 22 dogs dog NNS cord-023095-4dannjjm 3190 23 . . . cord-023095-4dannjjm 3191 1 Medical medical JJ cord-023095-4dannjjm 3191 2 records record NNS cord-023095-4dannjjm 3191 3 were be VBD cord-023095-4dannjjm 3191 4 evaluated evaluate VBN cord-023095-4dannjjm 3191 5 retrospectively retrospectively RB cord-023095-4dannjjm 3191 6 to to TO cord-023095-4dannjjm 3191 7 identify identify VB cord-023095-4dannjjm 3191 8 dogs dog NNS cord-023095-4dannjjm 3191 9 that that DT cord-023095-4dannjjm 3191 10 received receive VBD cord-023095-4dannjjm 3191 11 PC pc NN cord-023095-4dannjjm 3191 12 . . . cord-023095-4dannjjm 3192 1 Information information NN cord-023095-4dannjjm 3192 2 evaluated evaluate VBD cord-023095-4dannjjm 3192 3 included include VBN cord-023095-4dannjjm 3192 4 patient patient JJ cord-023095-4dannjjm 3192 5 characteristics characteristic NNS cord-023095-4dannjjm 3192 6 , , , cord-023095-4dannjjm 3192 7 platelet platelet NN cord-023095-4dannjjm 3192 8 count count NN cord-023095-4dannjjm 3192 9 , , , cord-023095-4dannjjm 3192 10 acute acute JJ cord-023095-4dannjjm 3192 11 transfusion transfusion NN cord-023095-4dannjjm 3192 12 reactions reaction NNS cord-023095-4dannjjm 3192 13 , , , cord-023095-4dannjjm 3192 14 and and CC cord-023095-4dannjjm 3192 15 survival survival NN cord-023095-4dannjjm 3192 16 . . . cord-023095-4dannjjm 3193 1 Twenty twenty CD cord-023095-4dannjjm 3193 2 six six CD cord-023095-4dannjjm 3193 3 dogs dog NNS cord-023095-4dannjjm 3193 4 met meet VBD cord-023095-4dannjjm 3193 5 study study NN cord-023095-4dannjjm 3193 6 criteria criterion NNS cord-023095-4dannjjm 3193 7 . . . cord-023095-4dannjjm 3194 1 Dogs dog NNS cord-023095-4dannjjm 3194 2 receiving receive VBG cord-023095-4dannjjm 3194 3 PC pc NN cord-023095-4dannjjm 3194 4 ranged range VBD cord-023095-4dannjjm 3194 5 in in IN cord-023095-4dannjjm 3194 6 age age NN cord-023095-4dannjjm 3194 7 from from IN cord-023095-4dannjjm 3194 8 1 1 CD cord-023095-4dannjjm 3194 9 - - SYM cord-023095-4dannjjm 3194 10 13 13 CD cord-023095-4dannjjm 3194 11 years year NNS cord-023095-4dannjjm 3194 12 ( ( -LRB- cord-023095-4dannjjm 3194 13 mean mean VB cord-023095-4dannjjm 3194 14 7.8 7.8 CD cord-023095-4dannjjm 3194 15 years year NNS cord-023095-4dannjjm 3194 16 ) ) -RRB- cord-023095-4dannjjm 3194 17 and and CC cord-023095-4dannjjm 3194 18 17/26 17/26 CD cord-023095-4dannjjm 3194 19 ( ( -LRB- cord-023095-4dannjjm 3194 20 65.4 65.4 CD cord-023095-4dannjjm 3194 21 % % NN cord-023095-4dannjjm 3194 22 ) ) -RRB- cord-023095-4dannjjm 3194 23 were be VBD cord-023095-4dannjjm 3194 24 spayed spay VBN cord-023095-4dannjjm 3194 25 or or CC cord-023095-4dannjjm 3194 26 intact intact JJ cord-023095-4dannjjm 3194 27 females female NNS cord-023095-4dannjjm 3194 28 . . . cord-023095-4dannjjm 3195 1 Hemorrhage hemorrhage NN cord-023095-4dannjjm 3195 2 was be VBD cord-023095-4dannjjm 3195 3 reported report VBN cord-023095-4dannjjm 3195 4 in in IN cord-023095-4dannjjm 3195 5 20/26 20/26 CD cord-023095-4dannjjm 3195 6 dogs dog NNS cord-023095-4dannjjm 3195 7 ( ( -LRB- cord-023095-4dannjjm 3195 8 76.9 76.9 CD cord-023095-4dannjjm 3195 9 % % NN cord-023095-4dannjjm 3195 10 ) ) -RRB- cord-023095-4dannjjm 3195 11 prior prior RB cord-023095-4dannjjm 3195 12 to to IN cord-023095-4dannjjm 3195 13 PC pc NN cord-023095-4dannjjm 3195 14 transfusion transfusion NN cord-023095-4dannjjm 3195 15 . . . cord-023095-4dannjjm 3196 1 Platelet platelet NN cord-023095-4dannjjm 3196 2 counts count VBZ cord-023095-4dannjjm 3196 3 prior prior RB cord-023095-4dannjjm 3196 4 to to IN cord-023095-4dannjjm 3196 5 transfusion transfusion NN cord-023095-4dannjjm 3196 6 ranged range VBD cord-023095-4dannjjm 3196 7 from from IN cord-023095-4dannjjm 3196 8 0 0 CD cord-023095-4dannjjm 3196 9 to to IN cord-023095-4dannjjm 3196 10 77 77 CD cord-023095-4dannjjm 3196 11 Â â CD cord-023095-4dannjjm 3196 12 10 10 CD cord-023095-4dannjjm 3196 13 3 3 CD cord-023095-4dannjjm 3196 14 /ul /ul . cord-023095-4dannjjm 3197 1 ( ( -LRB- cord-023095-4dannjjm 3197 2 mean mean VB cord-023095-4dannjjm 3197 3 29.9 29.9 CD cord-023095-4dannjjm 3197 4 1 1 CD cord-023095-4dannjjm 3198 1 /À43.9 /À43.9 . cord-023095-4dannjjm 3199 1 Â â CD cord-023095-4dannjjm 3199 2 10 10 CD cord-023095-4dannjjm 3199 3 3 3 CD cord-023095-4dannjjm 3199 4 /ul /ul . cord-023095-4dannjjm 3199 5 ) ) -RRB- cord-023095-4dannjjm 3199 6 . . . cord-023095-4dannjjm 3200 1 Change change VB cord-023095-4dannjjm 3200 2 in in IN cord-023095-4dannjjm 3200 3 platelet platelet NN cord-023095-4dannjjm 3200 4 count count NN cord-023095-4dannjjm 3200 5 was be VBD cord-023095-4dannjjm 3200 6 measured measure VBN cord-023095-4dannjjm 3200 7 in in IN cord-023095-4dannjjm 3200 8 23 23 CD cord-023095-4dannjjm 3200 9 dogs dog NNS cord-023095-4dannjjm 3200 10 and and CC cord-023095-4dannjjm 3200 11 the the DT cord-023095-4dannjjm 3200 12 mean mean JJ cord-023095-4dannjjm 3200 13 change change NN cord-023095-4dannjjm 3200 14 was17.1 was17.1 NNP cord-023095-4dannjjm 3200 15 1 1 CD cord-023095-4dannjjm 3200 16 / / SYM cord-023095-4dannjjm 3200 17 À à NN cord-023095-4dannjjm 3200 18 45.5 45.5 CD cord-023095-4dannjjm 3200 19 Â â CD cord-023095-4dannjjm 3200 20 10 10 CD cord-023095-4dannjjm 3200 21 3 3 CD cord-023095-4dannjjm 3200 22 /ul /ul . cord-023095-4dannjjm 3200 23 . . . cord-023095-4dannjjm 3201 1 Dose dose NN cord-023095-4dannjjm 3201 2 of of IN cord-023095-4dannjjm 3201 3 PC pc NN cord-023095-4dannjjm 3201 4 administered administer VBN cord-023095-4dannjjm 3201 5 ranged range VBD cord-023095-4dannjjm 3201 6 from from IN cord-023095-4dannjjm 3201 7 4.8 4.8 CD cord-023095-4dannjjm 3201 8 to to IN cord-023095-4dannjjm 3201 9 40 40 CD cord-023095-4dannjjm 3201 10 ml ml NNS cord-023095-4dannjjm 3201 11 / / SYM cord-023095-4dannjjm 3201 12 kg kg NN cord-023095-4dannjjm 3201 13 with with IN cord-023095-4dannjjm 3201 14 a a DT cord-023095-4dannjjm 3201 15 mean mean NN cord-023095-4dannjjm 3201 16 of of IN cord-023095-4dannjjm 3201 17 14.5 14.5 CD cord-023095-4dannjjm 3201 18 1 1 CD cord-023095-4dannjjm 3201 19 / / SYM cord-023095-4dannjjm 3201 20 À à NN cord-023095-4dannjjm 3201 21 8.8 8.8 CD cord-023095-4dannjjm 3201 22 ml ml NNS cord-023095-4dannjjm 3201 23 / / SYM cord-023095-4dannjjm 3201 24 kg kg NN cord-023095-4dannjjm 3201 25 . . . cord-023095-4dannjjm 3202 1 No no DT cord-023095-4dannjjm 3202 2 acute acute JJ cord-023095-4dannjjm 3202 3 adverse adverse JJ cord-023095-4dannjjm 3202 4 reactions reaction NNS cord-023095-4dannjjm 3202 5 were be VBD cord-023095-4dannjjm 3202 6 reported report VBN cord-023095-4dannjjm 3202 7 . . . cord-023095-4dannjjm 3203 1 There there EX cord-023095-4dannjjm 3203 2 was be VBD cord-023095-4dannjjm 3203 3 no no DT cord-023095-4dannjjm 3203 4 correlation correlation NN cord-023095-4dannjjm 3203 5 between between IN cord-023095-4dannjjm 3203 6 transfusion transfusion NN cord-023095-4dannjjm 3203 7 dosage dosage NN cord-023095-4dannjjm 3203 8 and and CC cord-023095-4dannjjm 3203 9 platelet platelet NN cord-023095-4dannjjm 3203 10 count count NN cord-023095-4dannjjm 3203 11 change change NN cord-023095-4dannjjm 3203 12 post post NN cord-023095-4dannjjm 3203 13 transfusion transfusion NN cord-023095-4dannjjm 3203 14 . . . cord-023095-4dannjjm 3204 1 Survival survival NN cord-023095-4dannjjm 3204 2 to to TO cord-023095-4dannjjm 3204 3 discharge discharge NN cord-023095-4dannjjm 3204 4 occurred occur VBD cord-023095-4dannjjm 3204 5 in in IN cord-023095-4dannjjm 3204 6 15/26 15/26 CD cord-023095-4dannjjm 3204 7 ( ( -LRB- cord-023095-4dannjjm 3204 8 57.7 57.7 CD cord-023095-4dannjjm 3204 9 % % NN cord-023095-4dannjjm 3204 10 ) ) -RRB- cord-023095-4dannjjm 3204 11 of of IN cord-023095-4dannjjm 3204 12 dogs dog NNS cord-023095-4dannjjm 3204 13 . . . cord-023095-4dannjjm 3205 1 The the DT cord-023095-4dannjjm 3205 2 only only JJ cord-023095-4dannjjm 3205 3 variable variable NN cord-023095-4dannjjm 3205 4 correlated correlate VBN cord-023095-4dannjjm 3205 5 with with IN cord-023095-4dannjjm 3205 6 survival survival NN cord-023095-4dannjjm 3205 7 was be VBD cord-023095-4dannjjm 3205 8 age age NN cord-023095-4dannjjm 3205 9 with with IN cord-023095-4dannjjm 3205 10 survivors survivor NNS cord-023095-4dannjjm 3205 11 being be VBG cord-023095-4dannjjm 3205 12 younger young JJR cord-023095-4dannjjm 3205 13 than than IN cord-023095-4dannjjm 3205 14 non non NNS cord-023095-4dannjjm 3205 15 - - NNS cord-023095-4dannjjm 3205 16 survivors survivor NNS cord-023095-4dannjjm 3205 17 ( ( -LRB- cord-023095-4dannjjm 3205 18 6.4 6.4 CD cord-023095-4dannjjm 3205 19 years year NNS cord-023095-4dannjjm 3205 20 - - HYPH cord-023095-4dannjjm 3205 21 old old JJ cord-023095-4dannjjm 3205 22 AE AE NNP cord-023095-4dannjjm 3205 23 3.9 3.9 CD cord-023095-4dannjjm 3205 24 vs. vs. NN cord-023095-4dannjjm 3205 25 10.1 10.1 CD cord-023095-4dannjjm 3205 26 years year NNS cord-023095-4dannjjm 3205 27 - - HYPH cord-023095-4dannjjm 3205 28 old old JJ cord-023095-4dannjjm 3205 29 AE AE NNP cord-023095-4dannjjm 3205 30 3.1 3.1 CD cord-023095-4dannjjm 3205 31 . . . cord-023095-4dannjjm 3205 32 ; ; : cord-023095-4dannjjm 3205 33 p p NN cord-023095-4dannjjm 3205 34 5 5 CD cord-023095-4dannjjm 3205 35 0.02 0.02 CD cord-023095-4dannjjm 3205 36 ) ) -RRB- cord-023095-4dannjjm 3205 37 . . . cord-023095-4dannjjm 3206 1 Efficacy efficacy NN cord-023095-4dannjjm 3206 2 of of IN cord-023095-4dannjjm 3206 3 cryopreserved cryopreserved JJ cord-023095-4dannjjm 3206 4 PC pc NN cord-023095-4dannjjm 3206 5 transfusions transfusion NNS cord-023095-4dannjjm 3206 6 for for IN cord-023095-4dannjjm 3206 7 improving improve VBG cord-023095-4dannjjm 3206 8 clinical clinical JJ cord-023095-4dannjjm 3206 9 outcome outcome NN cord-023095-4dannjjm 3206 10 in in IN cord-023095-4dannjjm 3206 11 dogs dog NNS cord-023095-4dannjjm 3206 12 with with IN cord-023095-4dannjjm 3206 13 thrombocytopenia thrombocytopenia NN cord-023095-4dannjjm 3206 14 is be VBZ cord-023095-4dannjjm 3206 15 yet yet RB cord-023095-4dannjjm 3206 16 to to TO cord-023095-4dannjjm 3206 17 be be VB cord-023095-4dannjjm 3206 18 determined determine VBN cord-023095-4dannjjm 3206 19 ; ; : cord-023095-4dannjjm 3206 20 however however RB cord-023095-4dannjjm 3206 21 , , , cord-023095-4dannjjm 3206 22 PC PC NNP cord-023095-4dannjjm 3206 23 is be VBZ cord-023095-4dannjjm 3206 24 well well RB cord-023095-4dannjjm 3206 25 tolerated tolerate VBN cord-023095-4dannjjm 3206 26 in in IN cord-023095-4dannjjm 3206 27 clinical clinical JJ cord-023095-4dannjjm 3206 28 patients patient NNS cord-023095-4dannjjm 3206 29 . . . cord-023095-4dannjjm 3207 1 Fresh fresh JJ cord-023095-4dannjjm 3207 2 frozen frozen JJ cord-023095-4dannjjm 3207 3 plasma plasma NN cord-023095-4dannjjm 3207 4 ( ( -LRB- cord-023095-4dannjjm 3207 5 FFP FFP NNP cord-023095-4dannjjm 3207 6 ) ) -RRB- cord-023095-4dannjjm 3207 7 is be VBZ cord-023095-4dannjjm 3207 8 used use VBN cord-023095-4dannjjm 3207 9 to to TO cord-023095-4dannjjm 3207 10 treat treat VB cord-023095-4dannjjm 3207 11 coagulopathies coagulopathie NNS cord-023095-4dannjjm 3207 12 in in IN cord-023095-4dannjjm 3207 13 dogs dog NNS cord-023095-4dannjjm 3207 14 . . . cord-023095-4dannjjm 3208 1 Current current JJ cord-023095-4dannjjm 3208 2 transfusion transfusion NN cord-023095-4dannjjm 3208 3 guidelines guideline NNS cord-023095-4dannjjm 3208 4 recommend recommend VBP cord-023095-4dannjjm 3208 5 that that IN cord-023095-4dannjjm 3208 6 FFP FFP NNP cord-023095-4dannjjm 3208 7 be be VB cord-023095-4dannjjm 3208 8 administered administer VBN cord-023095-4dannjjm 3208 9 within within IN cord-023095-4dannjjm 3208 10 4 4 CD cord-023095-4dannjjm 3208 11 hours hour NNS cord-023095-4dannjjm 3208 12 of of IN cord-023095-4dannjjm 3208 13 thawing thawing NN cord-023095-4dannjjm 3208 14 to to TO cord-023095-4dannjjm 3208 15 avoid avoid VB cord-023095-4dannjjm 3208 16 decreasing decrease VBG cord-023095-4dannjjm 3208 17 clotting clotting NN cord-023095-4dannjjm 3208 18 factor factor NN cord-023095-4dannjjm 3208 19 function function NN cord-023095-4dannjjm 3208 20 and and CC cord-023095-4dannjjm 3208 21 bacterial bacterial JJ cord-023095-4dannjjm 3208 22 contamination contamination NN cord-023095-4dannjjm 3208 23 . . . cord-023095-4dannjjm 3209 1 The the DT cord-023095-4dannjjm 3209 2 purpose purpose NN cord-023095-4dannjjm 3209 3 of of IN cord-023095-4dannjjm 3209 4 this this DT cord-023095-4dannjjm 3209 5 study study NN cord-023095-4dannjjm 3209 6 was be VBD cord-023095-4dannjjm 3209 7 to to TO cord-023095-4dannjjm 3209 8 assess assess VB cord-023095-4dannjjm 3209 9 clotting clotting NN cord-023095-4dannjjm 3209 10 factor factor NN cord-023095-4dannjjm 3209 11 activity activity NN cord-023095-4dannjjm 3209 12 and and CC cord-023095-4dannjjm 3209 13 bacterial bacterial JJ cord-023095-4dannjjm 3209 14 contamination contamination NN cord-023095-4dannjjm 3209 15 of of IN cord-023095-4dannjjm 3209 16 FFP FFP NNP cord-023095-4dannjjm 3209 17 that that WDT cord-023095-4dannjjm 3209 18 had have VBD cord-023095-4dannjjm 3209 19 been be VBN cord-023095-4dannjjm 3209 20 thawed thaw VBN cord-023095-4dannjjm 3209 21 and and CC cord-023095-4dannjjm 3209 22 refrigerated refrigerate VBN cord-023095-4dannjjm 3209 23 for for IN cord-023095-4dannjjm 3209 24 5 5 CD cord-023095-4dannjjm 3209 25 days day NNS cord-023095-4dannjjm 3209 26 . . . cord-023095-4dannjjm 3210 1 Blood blood NN cord-023095-4dannjjm 3210 2 was be VBD cord-023095-4dannjjm 3210 3 collected collect VBN cord-023095-4dannjjm 3210 4 from from IN cord-023095-4dannjjm 3210 5 10 10 CD cord-023095-4dannjjm 3210 6 client client NN cord-023095-4dannjjm 3210 7 - - HYPH cord-023095-4dannjjm 3210 8 owned own VBN cord-023095-4dannjjm 3210 9 healthy healthy JJ cord-023095-4dannjjm 3210 10 dogs dog NNS cord-023095-4dannjjm 3210 11 with with IN cord-023095-4dannjjm 3210 12 no no DT cord-023095-4dannjjm 3210 13 known know VBN cord-023095-4dannjjm 3210 14 history history NN cord-023095-4dannjjm 3210 15 of of IN cord-023095-4dannjjm 3210 16 coagulopathy coagulopathy NN cord-023095-4dannjjm 3210 17 or or CC cord-023095-4dannjjm 3210 18 of of IN cord-023095-4dannjjm 3210 19 administration administration NN cord-023095-4dannjjm 3210 20 of of IN cord-023095-4dannjjm 3210 21 drugs drug NNS cord-023095-4dannjjm 3210 22 affecting affect VBG cord-023095-4dannjjm 3210 23 coagulation coagulation NN cord-023095-4dannjjm 3210 24 . . . cord-023095-4dannjjm 3211 1 Plasma plasma NN cord-023095-4dannjjm 3211 2 was be VBD cord-023095-4dannjjm 3211 3 separated separate VBN cord-023095-4dannjjm 3211 4 from from IN cord-023095-4dannjjm 3211 5 whole whole JJ cord-023095-4dannjjm 3211 6 blood blood NN cord-023095-4dannjjm 3211 7 and and CC cord-023095-4dannjjm 3211 8 frozen frozen JJ cord-023095-4dannjjm 3211 9 ( ( -LRB- cord-023095-4dannjjm 3211 10 À201C À201C NNP cord-023095-4dannjjm 3211 11 ) ) -RRB- cord-023095-4dannjjm 3211 12 within within IN cord-023095-4dannjjm 3211 13 30 30 CD cord-023095-4dannjjm 3211 14 minutes minute NNS cord-023095-4dannjjm 3211 15 of of IN cord-023095-4dannjjm 3211 16 collection collection NN cord-023095-4dannjjm 3211 17 . . . cord-023095-4dannjjm 3212 1 Thawed thawed JJ cord-023095-4dannjjm 3212 2 plasma plasma NN cord-023095-4dannjjm 3212 3 was be VBD cord-023095-4dannjjm 3212 4 maintained maintain VBN cord-023095-4dannjjm 3212 5 at at IN cord-023095-4dannjjm 3212 6 41C 41c CD cord-023095-4dannjjm 3212 7 ( ( -LRB- cord-023095-4dannjjm 3212 8 1 1 CD cord-023095-4dannjjm 3212 9 / / SYM cord-023095-4dannjjm 3212 10 À21C À21C NNP cord-023095-4dannjjm 3212 11 ) ) -RRB- cord-023095-4dannjjm 3212 12 . . . cord-023095-4dannjjm 3213 1 Aerobic aerobic JJ cord-023095-4dannjjm 3213 2 and and CC cord-023095-4dannjjm 3213 3 anaerobic anaerobic JJ cord-023095-4dannjjm 3213 4 bacterial bacterial JJ cord-023095-4dannjjm 3213 5 culture culture NN cord-023095-4dannjjm 3213 6 , , , cord-023095-4dannjjm 3213 7 prothrombin prothrombin JJ cord-023095-4dannjjm 3213 8 time time NN cord-023095-4dannjjm 3213 9 ( ( -LRB- cord-023095-4dannjjm 3213 10 PT PT NNP cord-023095-4dannjjm 3213 11 ) ) -RRB- cord-023095-4dannjjm 3213 12 , , , cord-023095-4dannjjm 3213 13 activated activate VBD cord-023095-4dannjjm 3213 14 partial partial JJ cord-023095-4dannjjm 3213 15 thromboplastin thromboplastin NNP cord-023095-4dannjjm 3213 16 time time NN cord-023095-4dannjjm 3213 17 ( ( -LRB- cord-023095-4dannjjm 3213 18 PTT PTT NNP cord-023095-4dannjjm 3213 19 ) ) -RRB- cord-023095-4dannjjm 3213 20 , , , cord-023095-4dannjjm 3213 21 and and CC cord-023095-4dannjjm 3213 22 factor factor NN cord-023095-4dannjjm 3213 23 II II NNP cord-023095-4dannjjm 3213 24 , , , cord-023095-4dannjjm 3213 25 VII VII NNP cord-023095-4dannjjm 3213 26 , , , cord-023095-4dannjjm 3213 27 IX IX NNP cord-023095-4dannjjm 3213 28 , , , cord-023095-4dannjjm 3213 29 and and CC cord-023095-4dannjjm 3213 30 X x NN cord-023095-4dannjjm 3213 31 analyses analysis NNS cord-023095-4dannjjm 3213 32 were be VBD cord-023095-4dannjjm 3213 33 tested test VBN cord-023095-4dannjjm 3213 34 at at IN cord-023095-4dannjjm 3213 35 time time NN cord-023095-4dannjjm 3213 36 of of IN cord-023095-4dannjjm 3213 37 whole whole JJ cord-023095-4dannjjm 3213 38 blood blood NN cord-023095-4dannjjm 3213 39 collection collection NN cord-023095-4dannjjm 3213 40 , , , cord-023095-4dannjjm 3213 41 FFP FFP NNP cord-023095-4dannjjm 3213 42 thaw thaw NN cord-023095-4dannjjm 3213 43 , , , cord-023095-4dannjjm 3213 44 24 24 CD cord-023095-4dannjjm 3213 45 hours hour NNS cord-023095-4dannjjm 3213 46 post post NN cord-023095-4dannjjm 3213 47 - - NN cord-023095-4dannjjm 3213 48 thaw thaw JJ cord-023095-4dannjjm 3213 49 , , , cord-023095-4dannjjm 3213 50 72 72 CD cord-023095-4dannjjm 3213 51 hours hour NNS cord-023095-4dannjjm 3213 52 post post NN cord-023095-4dannjjm 3213 53 - - NN cord-023095-4dannjjm 3213 54 thaw thaw VB cord-023095-4dannjjm 3213 55 , , , cord-023095-4dannjjm 3213 56 and and CC cord-023095-4dannjjm 3213 57 120 120 CD cord-023095-4dannjjm 3213 58 hours hour NNS cord-023095-4dannjjm 3213 59 post post NN cord-023095-4dannjjm 3213 60 - - NN cord-023095-4dannjjm 3213 61 thaw thaw NN cord-023095-4dannjjm 3213 62 . . . cord-023095-4dannjjm 3214 1 There there EX cord-023095-4dannjjm 3214 2 were be VBD cord-023095-4dannjjm 3214 3 no no DT cord-023095-4dannjjm 3214 4 statistically statistically RB cord-023095-4dannjjm 3214 5 significant significant JJ cord-023095-4dannjjm 3214 6 differences difference NNS cord-023095-4dannjjm 3214 7 in in IN cord-023095-4dannjjm 3214 8 PT PT NNP cord-023095-4dannjjm 3214 9 and and CC cord-023095-4dannjjm 3214 10 PTT PTT NNP cord-023095-4dannjjm 3214 11 at at IN cord-023095-4dannjjm 3214 12 any any DT cord-023095-4dannjjm 3214 13 of of IN cord-023095-4dannjjm 3214 14 the the DT cord-023095-4dannjjm 3214 15 measured measure VBN cord-023095-4dannjjm 3214 16 time time NN cord-023095-4dannjjm 3214 17 points point NNS cord-023095-4dannjjm 3214 18 . . . cord-023095-4dannjjm 3215 1 Statistically statistically RB cord-023095-4dannjjm 3215 2 significant significant JJ cord-023095-4dannjjm 3215 3 differences difference NNS cord-023095-4dannjjm 3215 4 occurred occur VBD cord-023095-4dannjjm 3215 5 between between IN cord-023095-4dannjjm 3215 6 initial initial JJ cord-023095-4dannjjm 3215 7 measurements measurement NNS cord-023095-4dannjjm 3215 8 of of IN cord-023095-4dannjjm 3215 9 factors factor NNS cord-023095-4dannjjm 3215 10 II II NNP cord-023095-4dannjjm 3215 11 , , , cord-023095-4dannjjm 3215 12 VII VII NNP cord-023095-4dannjjm 3215 13 , , , cord-023095-4dannjjm 3215 14 IX IX NNP cord-023095-4dannjjm 3215 15 , , , cord-023095-4dannjjm 3215 16 and and CC cord-023095-4dannjjm 3215 17 X x NN cord-023095-4dannjjm 3215 18 and and CC cord-023095-4dannjjm 3215 19 subsequent subsequent JJ cord-023095-4dannjjm 3215 20 time time NN cord-023095-4dannjjm 3215 21 points point NNS cord-023095-4dannjjm 3215 22 , , , cord-023095-4dannjjm 3215 23 but but CC cord-023095-4dannjjm 3215 24 there there EX cord-023095-4dannjjm 3215 25 was be VBD cord-023095-4dannjjm 3215 26 no no DT cord-023095-4dannjjm 3215 27 difference difference NN cord-023095-4dannjjm 3215 28 in in IN cord-023095-4dannjjm 3215 29 activity activity NN cord-023095-4dannjjm 3215 30 levels level NNS cord-023095-4dannjjm 3215 31 of of IN cord-023095-4dannjjm 3215 32 the the DT cord-023095-4dannjjm 3215 33 factors factor NNS cord-023095-4dannjjm 3215 34 once once IN cord-023095-4dannjjm 3215 35 FFP FFP NNP cord-023095-4dannjjm 3215 36 was be VBD cord-023095-4dannjjm 3215 37 thawed thaw VBN cord-023095-4dannjjm 3215 38 . . . cord-023095-4dannjjm 3216 1 One one CD cord-023095-4dannjjm 3216 2 bacterial bacterial JJ cord-023095-4dannjjm 3216 3 colony colony NN cord-023095-4dannjjm 3216 4 was be VBD cord-023095-4dannjjm 3216 5 grown grow VBN cord-023095-4dannjjm 3216 6 from from IN cord-023095-4dannjjm 3216 7 each each DT cord-023095-4dannjjm 3216 8 of of IN cord-023095-4dannjjm 3216 9 two two CD cord-023095-4dannjjm 3216 10 samples sample NNS cord-023095-4dannjjm 3216 11 from from IN cord-023095-4dannjjm 3216 12 post post JJ cord-023095-4dannjjm 3216 13 - - JJ cord-023095-4dannjjm 3216 14 thaw thaw JJ cord-023095-4dannjjm 3216 15 plasma plasma NN cord-023095-4dannjjm 3216 16 . . . cord-023095-4dannjjm 3217 1 Thawed thawed JJ cord-023095-4dannjjm 3217 2 plasma plasma NN cord-023095-4dannjjm 3217 3 protocols protocol NNS cord-023095-4dannjjm 3217 4 do do VBP cord-023095-4dannjjm 3217 5 not not RB cord-023095-4dannjjm 3217 6 significantly significantly RB cord-023095-4dannjjm 3217 7 decrease decrease VB cord-023095-4dannjjm 3217 8 the the DT cord-023095-4dannjjm 3217 9 function function NN cord-023095-4dannjjm 3217 10 of of IN cord-023095-4dannjjm 3217 11 factors factor NNS cord-023095-4dannjjm 3217 12 II II NNP cord-023095-4dannjjm 3217 13 , , , cord-023095-4dannjjm 3217 14 VII VII NNP cord-023095-4dannjjm 3217 15 , , , cord-023095-4dannjjm 3217 16 IX IX NNP cord-023095-4dannjjm 3217 17 , , , cord-023095-4dannjjm 3217 18 and and CC cord-023095-4dannjjm 3217 19 X x NN cord-023095-4dannjjm 3217 20 or or CC cord-023095-4dannjjm 3217 21 prolong prolong VB cord-023095-4dannjjm 3217 22 PT PT NNP cord-023095-4dannjjm 3217 23 and and CC cord-023095-4dannjjm 3217 24 PTT PTT NNP cord-023095-4dannjjm 3217 25 . . . cord-023095-4dannjjm 3218 1 Bacterial bacterial JJ cord-023095-4dannjjm 3218 2 contamination contamination NN cord-023095-4dannjjm 3218 3 of of IN cord-023095-4dannjjm 3218 4 the the DT cord-023095-4dannjjm 3218 5 plasma plasma NN cord-023095-4dannjjm 3218 6 supply supply NN cord-023095-4dannjjm 3218 7 seems seem VBZ cord-023095-4dannjjm 3218 8 unlikely unlikely JJ cord-023095-4dannjjm 3218 9 , , , cord-023095-4dannjjm 3218 10 but but CC cord-023095-4dannjjm 3218 11 strict strict JJ cord-023095-4dannjjm 3218 12 aseptic aseptic JJ cord-023095-4dannjjm 3218 13 technique technique NN cord-023095-4dannjjm 3218 14 should should MD cord-023095-4dannjjm 3218 15 be be VB cord-023095-4dannjjm 3218 16 used use VBN cord-023095-4dannjjm 3218 17 when when WRB cord-023095-4dannjjm 3218 18 obtaining obtain VBG cord-023095-4dannjjm 3218 19 plasma plasma NN cord-023095-4dannjjm 3218 20 for for IN cord-023095-4dannjjm 3218 21 patient patient JJ cord-023095-4dannjjm 3218 22 use use NN cord-023095-4dannjjm 3218 23 . . . cord-023095-4dannjjm 3219 1 Erythrocyte Erythrocyte NNP cord-023095-4dannjjm 3219 2 pyruvate pyruvate NN cord-023095-4dannjjm 3219 3 kinase kinase NN cord-023095-4dannjjm 3219 4 ( ( -LRB- cord-023095-4dannjjm 3219 5 PK PK NNP cord-023095-4dannjjm 3219 6 ) ) -RRB- cord-023095-4dannjjm 3219 7 deficiency deficiency NN cord-023095-4dannjjm 3219 8 is be VBZ cord-023095-4dannjjm 3219 9 the the DT cord-023095-4dannjjm 3219 10 first first JJ cord-023095-4dannjjm 3219 11 and and CC cord-023095-4dannjjm 3219 12 most most RBS cord-023095-4dannjjm 3219 13 common common JJ cord-023095-4dannjjm 3219 14 erythroenzymopathy erythroenzymopathy NNS cord-023095-4dannjjm 3219 15 described describe VBN cord-023095-4dannjjm 3219 16 in in IN cord-023095-4dannjjm 3219 17 dogs dog NNS cord-023095-4dannjjm 3219 18 , , , cord-023095-4dannjjm 3219 19 cats cat NNS cord-023095-4dannjjm 3219 20 , , , cord-023095-4dannjjm 3219 21 and and CC cord-023095-4dannjjm 3219 22 humans human NNS cord-023095-4dannjjm 3219 23 . . . cord-023095-4dannjjm 3220 1 The the DT cord-023095-4dannjjm 3220 2 PK PK NNP cord-023095-4dannjjm 3220 3 enzyme enzyme NN cord-023095-4dannjjm 3220 4 plays play VBZ cord-023095-4dannjjm 3220 5 a a DT cord-023095-4dannjjm 3220 6 crucial crucial JJ cord-023095-4dannjjm 3220 7 role role NN cord-023095-4dannjjm 3220 8 in in IN cord-023095-4dannjjm 3220 9 the the DT cord-023095-4dannjjm 3220 10 erythrocyte erythrocyte NN cord-023095-4dannjjm 3220 11 energy energy NN cord-023095-4dannjjm 3220 12 metabolism metabolism NN cord-023095-4dannjjm 3220 13 and and CC cord-023095-4dannjjm 3220 14 its -PRON- PRP$ cord-023095-4dannjjm 3220 15 absence absence NN cord-023095-4dannjjm 3220 16 causes cause VBZ cord-023095-4dannjjm 3220 17 severe severe JJ cord-023095-4dannjjm 3220 18 hemolytic hemolytic JJ cord-023095-4dannjjm 3220 19 anemia anemia NN cord-023095-4dannjjm 3220 20 , , , cord-023095-4dannjjm 3220 21 often often RB cord-023095-4dannjjm 3220 22 misdiagnosed misdiagnose VBN cord-023095-4dannjjm 3220 23 as as IN cord-023095-4dannjjm 3220 24 autoimmune autoimmune JJ cord-023095-4dannjjm 3220 25 hemolytic hemolytic JJ cord-023095-4dannjjm 3220 26 anemia anemia NN cord-023095-4dannjjm 3220 27 . . . cord-023095-4dannjjm 3221 1 The the DT cord-023095-4dannjjm 3221 2 disease disease NN cord-023095-4dannjjm 3221 3 is be VBZ cord-023095-4dannjjm 3221 4 inherited inherit VBN cord-023095-4dannjjm 3221 5 as as IN cord-023095-4dannjjm 3221 6 an an DT cord-023095-4dannjjm 3221 7 autosomal autosomal JJ cord-023095-4dannjjm 3221 8 recessive recessive JJ cord-023095-4dannjjm 3221 9 trait trait NN cord-023095-4dannjjm 3221 10 and and CC cord-023095-4dannjjm 3221 11 affected affect VBN cord-023095-4dannjjm 3221 12 dogs dog NNS cord-023095-4dannjjm 3221 13 also also RB cord-023095-4dannjjm 3221 14 develop develop VBP cord-023095-4dannjjm 3221 15 osteosclerosis osteosclerosis NN cord-023095-4dannjjm 3221 16 . . . cord-023095-4dannjjm 3222 1 In in IN cord-023095-4dannjjm 3222 2 dogs dog NNS cord-023095-4dannjjm 3222 3 , , , cord-023095-4dannjjm 3222 4 the the DT cord-023095-4dannjjm 3222 5 enzymatic enzymatic JJ cord-023095-4dannjjm 3222 6 diagnosis diagnosis NN cord-023095-4dannjjm 3222 7 is be VBZ cord-023095-4dannjjm 3222 8 complicated complicate VBN cord-023095-4dannjjm 3222 9 by by IN cord-023095-4dannjjm 3222 10 the the DT cord-023095-4dannjjm 3222 11 anomalous anomalous JJ cord-023095-4dannjjm 3222 12 expression expression NN cord-023095-4dannjjm 3222 13 of of IN cord-023095-4dannjjm 3222 14 malfunctioning malfunction VBG cord-023095-4dannjjm 3222 15 M M NNP cord-023095-4dannjjm 3222 16 2 2 CD cord-023095-4dannjjm 3222 17 -PK -pk NN cord-023095-4dannjjm 3222 18 expression expression NN cord-023095-4dannjjm 3222 19 , , , cord-023095-4dannjjm 3222 20 but but CC cord-023095-4dannjjm 3222 21 breed breed NN cord-023095-4dannjjm 3222 22 - - HYPH cord-023095-4dannjjm 3222 23 specific specific JJ cord-023095-4dannjjm 3222 24 R r NN cord-023095-4dannjjm 3222 25 - - HYPH cord-023095-4dannjjm 3222 26 PK pk NN cord-023095-4dannjjm 3222 27 mutation mutation NN cord-023095-4dannjjm 3222 28 tests test NNS cord-023095-4dannjjm 3222 29 have have VBP cord-023095-4dannjjm 3222 30 been be VBN cord-023095-4dannjjm 3222 31 reported report VBN cord-023095-4dannjjm 3222 32 for for IN cord-023095-4dannjjm 3222 33 Basenjis Basenjis NNP cord-023095-4dannjjm 3222 34 , , , cord-023095-4dannjjm 3222 35 West West NNP cord-023095-4dannjjm 3222 36 Highland Highland NNP cord-023095-4dannjjm 3222 37 White White NNP cord-023095-4dannjjm 3222 38 Terriers Terriers NNPS cord-023095-4dannjjm 3222 39 ( ( -LRB- cord-023095-4dannjjm 3222 40 WHWT WHWT NNP cord-023095-4dannjjm 3222 41 ) ) -RRB- cord-023095-4dannjjm 3222 42 , , , cord-023095-4dannjjm 3222 43 and and CC cord-023095-4dannjjm 3222 44 Beagles beagle NNS cord-023095-4dannjjm 3222 45 . . . cord-023095-4dannjjm 3223 1 We -PRON- PRP cord-023095-4dannjjm 3223 2 report report VBP cord-023095-4dannjjm 3223 3 here here RB cord-023095-4dannjjm 3223 4 on on IN cord-023095-4dannjjm 3223 5 a a DT cord-023095-4dannjjm 3223 6 survey survey NN cord-023095-4dannjjm 3223 7 of of IN cord-023095-4dannjjm 3223 8 canine canine JJ cord-023095-4dannjjm 3223 9 PK PK NNP cord-023095-4dannjjm 3223 10 deficiency deficiency NN cord-023095-4dannjjm 3223 11 studied study VBD cord-023095-4dannjjm 3223 12 at at IN cord-023095-4dannjjm 3223 13 the the DT cord-023095-4dannjjm 3223 14 PennGen PennGen NNP cord-023095-4dannjjm 3223 15 Laboratory Laboratory NNP cord-023095-4dannjjm 3223 16 . . . cord-023095-4dannjjm 3224 1 A a DT cord-023095-4dannjjm 3224 2 biased biased JJ cord-023095-4dannjjm 3224 3 group group NN cord-023095-4dannjjm 3224 4 of of IN cord-023095-4dannjjm 3224 5 samples sample NNS cord-023095-4dannjjm 3224 6 were be VBD cord-023095-4dannjjm 3224 7 received receive VBN cord-023095-4dannjjm 3224 8 for for IN cord-023095-4dannjjm 3224 9 screening screening NN cord-023095-4dannjjm 3224 10 from from IN cord-023095-4dannjjm 3224 11 dog dog NN cord-023095-4dannjjm 3224 12 breeds breed NNS cord-023095-4dannjjm 3224 13 with with IN cord-023095-4dannjjm 3224 14 known know VBN cord-023095-4dannjjm 3224 15 mutations mutation NNS cord-023095-4dannjjm 3224 16 as as RB cord-023095-4dannjjm 3224 17 well well RB cord-023095-4dannjjm 3224 18 as as IN cord-023095-4dannjjm 3224 19 from from IN cord-023095-4dannjjm 3224 20 dogs dog NNS cord-023095-4dannjjm 3224 21 with with IN cord-023095-4dannjjm 3224 22 chronic chronic JJ cord-023095-4dannjjm 3224 23 , , , cord-023095-4dannjjm 3224 24 prednisone prednisone NN cord-023095-4dannjjm 3224 25 - - HYPH cord-023095-4dannjjm 3224 26 and and CC cord-023095-4dannjjm 3224 27 antibiotic antibiotic JJ cord-023095-4dannjjm 3224 28 - - HYPH cord-023095-4dannjjm 3224 29 resistant resistant JJ cord-023095-4dannjjm 3224 30 hemolytic hemolytic JJ cord-023095-4dannjjm 3224 31 anemia anemia NN cord-023095-4dannjjm 3224 32 and and CC cord-023095-4dannjjm 3224 33 their -PRON- PRP$ cord-023095-4dannjjm 3224 34 relatives relative NNS cord-023095-4dannjjm 3224 35 . . . cord-023095-4dannjjm 3225 1 EDTA EDTA NNP cord-023095-4dannjjm 3225 2 blood blood NN cord-023095-4dannjjm 3225 3 samples sample NNS cord-023095-4dannjjm 3225 4 and/or and/or CC cord-023095-4dannjjm 3225 5 cheek cheek NN cord-023095-4dannjjm 3225 6 swabs swab NNS cord-023095-4dannjjm 3225 7 as as RB cord-023095-4dannjjm 3225 8 well well RB cord-023095-4dannjjm 3225 9 as as IN cord-023095-4dannjjm 3225 10 medical medical JJ cord-023095-4dannjjm 3225 11 record record NN cord-023095-4dannjjm 3225 12 information information NN cord-023095-4dannjjm 3225 13 were be VBD cord-023095-4dannjjm 3225 14 received receive VBN cord-023095-4dannjjm 3225 15 and and CC cord-023095-4dannjjm 3225 16 genomic genomic JJ cord-023095-4dannjjm 3225 17 DNA DNA NNP cord-023095-4dannjjm 3225 18 and/ and/ NNP cord-023095-4dannjjm 3225 19 or or CC cord-023095-4dannjjm 3225 20 enzyme enzyme NN cord-023095-4dannjjm 3225 21 activity activity NN cord-023095-4dannjjm 3225 22 testing testing NN cord-023095-4dannjjm 3225 23 were be VBD cord-023095-4dannjjm 3225 24 performed perform VBN cord-023095-4dannjjm 3225 25 . . . cord-023095-4dannjjm 3226 1 Among among IN cord-023095-4dannjjm 3226 2 the the DT cord-023095-4dannjjm 3226 3 237 237 CD cord-023095-4dannjjm 3226 4 WHWTs whwts JJ cord-023095-4dannjjm 3226 5 7 7 CD cord-023095-4dannjjm 3226 6 % % NN cord-023095-4dannjjm 3226 7 and and CC cord-023095-4dannjjm 3226 8 37 37 CD cord-023095-4dannjjm 3226 9 % % NN cord-023095-4dannjjm 3226 10 were be VBD cord-023095-4dannjjm 3226 11 found find VBN cord-023095-4dannjjm 3226 12 to to TO cord-023095-4dannjjm 3226 13 be be VB cord-023095-4dannjjm 3226 14 homozygous homozygous JJ cord-023095-4dannjjm 3226 15 deficient deficient JJ cord-023095-4dannjjm 3226 16 dogs dog NNS cord-023095-4dannjjm 3226 17 or or CC cord-023095-4dannjjm 3226 18 carriers carrier NNS cord-023095-4dannjjm 3226 19 , , , cord-023095-4dannjjm 3226 20 respectively respectively RB cord-023095-4dannjjm 3226 21 , , , cord-023095-4dannjjm 3226 22 with with IN cord-023095-4dannjjm 3226 23 a a DT cord-023095-4dannjjm 3226 24 mutant mutant JJ cord-023095-4dannjjm 3226 25 allele allele NN cord-023095-4dannjjm 3226 26 frequency frequency NN cord-023095-4dannjjm 3226 27 of of IN cord-023095-4dannjjm 3226 28 0.26 0.26 CD cord-023095-4dannjjm 3226 29 . . . cord-023095-4dannjjm 3227 1 The the DT cord-023095-4dannjjm 3227 2 average average JJ cord-023095-4dannjjm 3227 3 age age NN cord-023095-4dannjjm 3227 4 at at IN cord-023095-4dannjjm 3227 5 the the DT cord-023095-4dannjjm 3227 6 time time NN cord-023095-4dannjjm 3227 7 of of IN cord-023095-4dannjjm 3227 8 diagnosis diagnosis NN cord-023095-4dannjjm 3227 9 was be VBD cord-023095-4dannjjm 3227 10 1.5 1.5 CD cord-023095-4dannjjm 3227 11 years year NNS cord-023095-4dannjjm 3227 12 ranging range VBG cord-023095-4dannjjm 3227 13 from from IN cord-023095-4dannjjm 3227 14 2 2 CD cord-023095-4dannjjm 3227 15 months month NNS cord-023095-4dannjjm 3227 16 to to IN cord-023095-4dannjjm 3227 17 5 5 CD cord-023095-4dannjjm 3227 18 years year NNS cord-023095-4dannjjm 3227 19 of of IN cord-023095-4dannjjm 3227 20 age age NN cord-023095-4dannjjm 3227 21 ; ; , cord-023095-4dannjjm 3227 22 some some DT cord-023095-4dannjjm 3227 23 samples sample NNS cord-023095-4dannjjm 3227 24 came come VBD cord-023095-4dannjjm 3227 25 from from IN cord-023095-4dannjjm 3227 26 Europe Europe NNP cord-023095-4dannjjm 3227 27 and and CC cord-023095-4dannjjm 3227 28 South South NNP cord-023095-4dannjjm 3227 29 America America NNP cord-023095-4dannjjm 3227 30 . . . cord-023095-4dannjjm 3228 1 Of of IN cord-023095-4dannjjm 3228 2 the the DT cord-023095-4dannjjm 3228 3 67 67 CD cord-023095-4dannjjm 3228 4 Beagles Beagles NNPS cord-023095-4dannjjm 3228 5 studied study VBD cord-023095-4dannjjm 3228 6 , , , cord-023095-4dannjjm 3228 7 36 36 CD cord-023095-4dannjjm 3228 8 % % NN cord-023095-4dannjjm 3228 9 were be VBD cord-023095-4dannjjm 3228 10 affected affect VBN cord-023095-4dannjjm 3228 11 and and CC cord-023095-4dannjjm 3228 12 3 3 CD cord-023095-4dannjjm 3228 13 % % NN cord-023095-4dannjjm 3228 14 were be VBD cord-023095-4dannjjm 3228 15 carriers carrier NNS cord-023095-4dannjjm 3228 16 ( ( -LRB- cord-023095-4dannjjm 3228 17 mutant mutant JJ cord-023095-4dannjjm 3228 18 allele allele NN cord-023095-4dannjjm 3228 19 frequency frequency NN cord-023095-4dannjjm 3228 20 0.37 0.37 CD cord-023095-4dannjjm 3228 21 ) ) -RRB- cord-023095-4dannjjm 3228 22 . . . cord-023095-4dannjjm 3229 1 The the DT cord-023095-4dannjjm 3229 2 average average JJ cord-023095-4dannjjm 3229 3 age age NN cord-023095-4dannjjm 3229 4 at at IN cord-023095-4dannjjm 3229 5 the the DT cord-023095-4dannjjm 3229 6 time time NN cord-023095-4dannjjm 3229 7 of of IN cord-023095-4dannjjm 3229 8 diagnosis diagnosis NN cord-023095-4dannjjm 3229 9 was be VBD cord-023095-4dannjjm 3229 10 2 2 CD cord-023095-4dannjjm 3229 11 years year NNS cord-023095-4dannjjm 3229 12 ranging range VBG cord-023095-4dannjjm 3229 13 from from IN cord-023095-4dannjjm 3229 14 7 7 CD cord-023095-4dannjjm 3229 15 months month NNS cord-023095-4dannjjm 3229 16 to to IN cord-023095-4dannjjm 3229 17 9 9 CD cord-023095-4dannjjm 3229 18 years year NNS cord-023095-4dannjjm 3229 19 . . . cord-023095-4dannjjm 3230 1 Surprisingly surprisingly RB cord-023095-4dannjjm 3230 2 , , , cord-023095-4dannjjm 3230 3 very very RB cord-023095-4dannjjm 3230 4 few few JJ cord-023095-4dannjjm 3230 5 samples sample NNS cord-023095-4dannjjm 3230 6 from from IN cord-023095-4dannjjm 3230 7 Basenjis Basenjis NNPS cord-023095-4dannjjm 3230 8 were be VBD cord-023095-4dannjjm 3230 9 received receive VBN cord-023095-4dannjjm 3230 10 for for IN cord-023095-4dannjjm 3230 11 screening screening NN cord-023095-4dannjjm 3230 12 , , , cord-023095-4dannjjm 3230 13 and and CC cord-023095-4dannjjm 3230 14 none none NN cord-023095-4dannjjm 3230 15 showed show VBD cord-023095-4dannjjm 3230 16 the the DT cord-023095-4dannjjm 3230 17 mutant mutant JJ cord-023095-4dannjjm 3230 18 allele allele NN cord-023095-4dannjjm 3230 19 . . . cord-023095-4dannjjm 3231 1 While while IN cord-023095-4dannjjm 3231 2 PK PK NNP cord-023095-4dannjjm 3231 3 - - HYPH cord-023095-4dannjjm 3231 4 deficient deficient JJ cord-023095-4dannjjm 3231 5 Basenjis Basenjis NNPS cord-023095-4dannjjm 3231 6 lived live VBD cord-023095-4dannjjm 3231 7 o o NN cord-023095-4dannjjm 3231 8 5 5 CD cord-023095-4dannjjm 3231 9 years year NNS cord-023095-4dannjjm 3231 10 , , , cord-023095-4dannjjm 3231 11 WHWT WHWT NNP cord-023095-4dannjjm 3231 12 and and CC cord-023095-4dannjjm 3231 13 Beagles Beagles NNPS cord-023095-4dannjjm 3231 14 often often RB cord-023095-4dannjjm 3231 15 show show VBP cord-023095-4dannjjm 3231 16 milder mild JJR cord-023095-4dannjjm 3231 17 signs sign NNS cord-023095-4dannjjm 3231 18 and and CC cord-023095-4dannjjm 3231 19 can can MD cord-023095-4dannjjm 3231 20 reach reach VB cord-023095-4dannjjm 3231 21 9 9 CD cord-023095-4dannjjm 3231 22 years year NNS cord-023095-4dannjjm 3231 23 of of IN cord-023095-4dannjjm 3231 24 age age NN cord-023095-4dannjjm 3231 25 . . . cord-023095-4dannjjm 3232 1 Several several JJ cord-023095-4dannjjm 3232 2 dogs dog NNS cord-023095-4dannjjm 3232 3 from from IN cord-023095-4dannjjm 3232 4 other other JJ cord-023095-4dannjjm 3232 5 breeds breed NNS cord-023095-4dannjjm 3232 6 were be VBD cord-023095-4dannjjm 3232 7 also also RB cord-023095-4dannjjm 3232 8 examined examine VBN cord-023095-4dannjjm 3232 9 because because IN cord-023095-4dannjjm 3232 10 of of IN cord-023095-4dannjjm 3232 11 chronic chronic JJ cord-023095-4dannjjm 3232 12 regenerative regenerative JJ cord-023095-4dannjjm 3232 13 anemia anemia NN cord-023095-4dannjjm 3232 14 and and CC cord-023095-4dannjjm 3232 15 none none NN cord-023095-4dannjjm 3232 16 had have VBD cord-023095-4dannjjm 3232 17 any any DT cord-023095-4dannjjm 3232 18 of of IN cord-023095-4dannjjm 3232 19 the the DT cord-023095-4dannjjm 3232 20 known know VBN cord-023095-4dannjjm 3232 21 mutations mutation NNS cord-023095-4dannjjm 3232 22 seen see VBN cord-023095-4dannjjm 3232 23 in in IN cord-023095-4dannjjm 3232 24 the the DT cord-023095-4dannjjm 3232 25 other other JJ cord-023095-4dannjjm 3232 26 breeds breed NNS cord-023095-4dannjjm 3232 27 . . . cord-023095-4dannjjm 3233 1 However however RB cord-023095-4dannjjm 3233 2 , , , cord-023095-4dannjjm 3233 3 based base VBN cord-023095-4dannjjm 3233 4 upon upon IN cord-023095-4dannjjm 3233 5 PK PK NNP cord-023095-4dannjjm 3233 6 enzyme enzyme NN cord-023095-4dannjjm 3233 7 activity activity NN cord-023095-4dannjjm 3233 8 studies study NNS cord-023095-4dannjjm 3233 9 , , , cord-023095-4dannjjm 3233 10 Chihuahua Chihuahua NNP cord-023095-4dannjjm 3233 11 , , , cord-023095-4dannjjm 3233 12 Dachshund Dachshund NNP cord-023095-4dannjjm 3233 13 , , , cord-023095-4dannjjm 3233 14 Miniature Miniature NNP cord-023095-4dannjjm 3233 15 Poodle Poodle NNP cord-023095-4dannjjm 3233 16 , , , cord-023095-4dannjjm 3233 17 Spitz Spitz NNP cord-023095-4dannjjm 3233 18 , , , cord-023095-4dannjjm 3233 19 Eskimo Eskimo NNP cord-023095-4dannjjm 3233 20 Toy Toy NNP cord-023095-4dannjjm 3233 21 , , , cord-023095-4dannjjm 3233 22 and and CC cord-023095-4dannjjm 3233 23 Labrador Labrador NNP cord-023095-4dannjjm 3233 24 Retriever Retriever NNP cord-023095-4dannjjm 3233 25 dogs dog NNS cord-023095-4dannjjm 3233 26 were be VBD cord-023095-4dannjjm 3233 27 found find VBN cord-023095-4dannjjm 3233 28 to to TO cord-023095-4dannjjm 3233 29 be be VB cord-023095-4dannjjm 3233 30 affected affect VBN cord-023095-4dannjjm 3233 31 ; ; : cord-023095-4dannjjm 3233 32 they -PRON- PRP cord-023095-4dannjjm 3233 33 also also RB cord-023095-4dannjjm 3233 34 had have VBD cord-023095-4dannjjm 3233 35 osteosclerosis osteosclerosis NN cord-023095-4dannjjm 3233 36 and and CC cord-023095-4dannjjm 3234 1 at at RB cord-023095-4dannjjm 3234 2 least least RBS cord-023095-4dannjjm 3234 3 one one CD cord-023095-4dannjjm 3234 4 Labrador Labrador NNP cord-023095-4dannjjm 3234 5 Retriever Retriever NNP cord-023095-4dannjjm 3234 6 developed develop VBD cord-023095-4dannjjm 3234 7 severe severe JJ cord-023095-4dannjjm 3234 8 hemochromatosis hemochromatosis NN cord-023095-4dannjjm 3234 9 ( ( -LRB- cord-023095-4dannjjm 3234 10 hepatic hepatic JJ cord-023095-4dannjjm 3234 11 iron iron NN cord-023095-4dannjjm 3234 12 37,300 37,300 CD cord-023095-4dannjjm 3234 13 ppm ppm NN cord-023095-4dannjjm 3234 14 ; ; : cord-023095-4dannjjm 3234 15 normal normal JJ cord-023095-4dannjjm 3234 16 o o NN cord-023095-4dannjjm 3234 17 1,200 1,200 CD cord-023095-4dannjjm 3234 18 ppm ppm NN cord-023095-4dannjjm 3234 19 , , , cord-023095-4dannjjm 3234 20 analyzed analyze VBN cord-023095-4dannjjm 3234 21 on on IN cord-023095-4dannjjm 3234 22 a a DT cord-023095-4dannjjm 3234 23 dry dry JJ cord-023095-4dannjjm 3234 24 weight weight NN cord-023095-4dannjjm 3234 25 basis basis NN cord-023095-4dannjjm 3234 26 ) ) -RRB- cord-023095-4dannjjm 3234 27 . . . cord-023095-4dannjjm 3235 1 Moreover moreover RB cord-023095-4dannjjm 3235 2 , , , cord-023095-4dannjjm 3235 3 sequencing sequencing NN cord-023095-4dannjjm 3235 4 of of IN cord-023095-4dannjjm 3235 5 the the DT cord-023095-4dannjjm 3235 6 R R NNP cord-023095-4dannjjm 3235 7 - - HYPH cord-023095-4dannjjm 3235 8 PK PK NNP cord-023095-4dannjjm 3235 9 cDNA cdna NN cord-023095-4dannjjm 3235 10 from from IN cord-023095-4dannjjm 3235 11 a a DT cord-023095-4dannjjm 3235 12 PK PK NNP cord-023095-4dannjjm 3235 13 - - HYPH cord-023095-4dannjjm 3235 14 deficient deficient JJ cord-023095-4dannjjm 3235 15 Labrador Labrador NNP cord-023095-4dannjjm 3235 16 Retriever Retriever NNP cord-023095-4dannjjm 3235 17 revealed reveal VBD cord-023095-4dannjjm 3235 18 a a DT cord-023095-4dannjjm 3235 19 new new JJ cord-023095-4dannjjm 3235 20 nonsense nonsense NN cord-023095-4dannjjm 3235 21 mutation mutation NN cord-023095-4dannjjm 3235 22 in in IN cord-023095-4dannjjm 3235 23 exon exon NN cord-023095-4dannjjm 3235 24 6 6 CD cord-023095-4dannjjm 3235 25 . . . cord-023095-4dannjjm 3236 1 In in IN cord-023095-4dannjjm 3236 2 conclusion conclusion NN cord-023095-4dannjjm 3236 3 , , , cord-023095-4dannjjm 3236 4 PK PK NNP cord-023095-4dannjjm 3236 5 deficiency deficiency NN cord-023095-4dannjjm 3236 6 appears appear VBZ cord-023095-4dannjjm 3236 7 to to TO cord-023095-4dannjjm 3236 8 be be VB cord-023095-4dannjjm 3236 9 a a DT cord-023095-4dannjjm 3236 10 common common JJ cord-023095-4dannjjm 3236 11 cause cause NN cord-023095-4dannjjm 3236 12 for for IN cord-023095-4dannjjm 3236 13 hemolytic hemolytic JJ cord-023095-4dannjjm 3236 14 anemia anemia NN cord-023095-4dannjjm 3236 15 in in IN cord-023095-4dannjjm 3236 16 certain certain JJ cord-023095-4dannjjm 3236 17 breeds breed NNS cord-023095-4dannjjm 3236 18 , , , cord-023095-4dannjjm 3236 19 and and CC cord-023095-4dannjjm 3236 20 mutation mutation NN cord-023095-4dannjjm 3236 21 testing testing NN cord-023095-4dannjjm 3236 22 makes make VBZ cord-023095-4dannjjm 3236 23 screening screening NN cord-023095-4dannjjm 3236 24 simple simple JJ cord-023095-4dannjjm 3236 25 . . . cord-023095-4dannjjm 3237 1 PK PK NNP cord-023095-4dannjjm 3237 2 deficiency deficiency NN cord-023095-4dannjjm 3237 3 should should MD cord-023095-4dannjjm 3237 4 also also RB cord-023095-4dannjjm 3237 5 be be VB cord-023095-4dannjjm 3237 6 considered consider VBN cord-023095-4dannjjm 3237 7 in in IN cord-023095-4dannjjm 3237 8 dogs dog NNS cord-023095-4dannjjm 3237 9 of of IN cord-023095-4dannjjm 3237 10 other other JJ cord-023095-4dannjjm 3237 11 breeds breed NNS cord-023095-4dannjjm 3237 12 which which WDT cord-023095-4dannjjm 3237 13 may may MD cord-023095-4dannjjm 3237 14 require require VB cord-023095-4dannjjm 3237 15 the the DT cord-023095-4dannjjm 3237 16 more more RBR cord-023095-4dannjjm 3237 17 cumbersome cumbersome JJ cord-023095-4dannjjm 3237 18 enzyme enzyme NN cord-023095-4dannjjm 3237 19 testing testing NN cord-023095-4dannjjm 3237 20 . . . cord-023095-4dannjjm 3238 1 Studies study NNS cord-023095-4dannjjm 3238 2 to to TO cord-023095-4dannjjm 3238 3 identify identify VB cord-023095-4dannjjm 3238 4 new new JJ cord-023095-4dannjjm 3238 5 mutations mutation NNS cord-023095-4dannjjm 3238 6 will will MD cord-023095-4dannjjm 3238 7 confirm confirm VB cord-023095-4dannjjm 3238 8 and and CC cord-023095-4dannjjm 3238 9 simplify simplify VB cord-023095-4dannjjm 3238 10 the the DT cord-023095-4dannjjm 3238 11 diagnosis diagnosis NN cord-023095-4dannjjm 3238 12 . . . cord-023095-4dannjjm 3239 1 Supported support VBN cord-023095-4dannjjm 3239 2 in in IN cord-023095-4dannjjm 3239 3 part part NN cord-023095-4dannjjm 3239 4 by by IN cord-023095-4dannjjm 3239 5 NIH NIH NNP cord-023095-4dannjjm 3240 1 grant grant NNP cord-023095-4dannjjm 3240 2 RR02512 RR02512 NNP cord-023095-4dannjjm 3240 3 . . . cord-023095-4dannjjm 3241 1 Immune immune NN cord-023095-4dannjjm 3241 2 - - HYPH cord-023095-4dannjjm 3241 3 mediated mediate VBN cord-023095-4dannjjm 3241 4 hemolytic hemolytic JJ cord-023095-4dannjjm 3241 5 anemia anemia NN cord-023095-4dannjjm 3241 6 ( ( -LRB- cord-023095-4dannjjm 3241 7 IMHA IMHA NNP cord-023095-4dannjjm 3241 8 ) ) -RRB- cord-023095-4dannjjm 3241 9 is be VBZ cord-023095-4dannjjm 3241 10 a a DT cord-023095-4dannjjm 3241 11 common common JJ cord-023095-4dannjjm 3241 12 hematological hematological JJ cord-023095-4dannjjm 3241 13 condition condition NN cord-023095-4dannjjm 3241 14 observed observe VBN cord-023095-4dannjjm 3241 15 in in IN cord-023095-4dannjjm 3241 16 dogs dog NNS cord-023095-4dannjjm 3241 17 . . . cord-023095-4dannjjm 3242 1 The the DT cord-023095-4dannjjm 3242 2 diagnosis diagnosis NN cord-023095-4dannjjm 3242 3 is be VBZ cord-023095-4dannjjm 3242 4 based base VBN cord-023095-4dannjjm 3242 5 on on IN cord-023095-4dannjjm 3242 6 clinical clinical JJ cord-023095-4dannjjm 3242 7 history history NN cord-023095-4dannjjm 3242 8 , , , cord-023095-4dannjjm 3242 9 presenting present VBG cord-023095-4dannjjm 3242 10 signs sign NNS cord-023095-4dannjjm 3242 11 and and CC cord-023095-4dannjjm 3242 12 hematological hematological JJ cord-023095-4dannjjm 3242 13 evidence evidence NN cord-023095-4dannjjm 3242 14 of of IN cord-023095-4dannjjm 3242 15 IMHA IMHA NNP cord-023095-4dannjjm 3242 16 such such JJ cord-023095-4dannjjm 3242 17 as as IN cord-023095-4dannjjm 3242 18 regenerative regenerative JJ cord-023095-4dannjjm 3242 19 anemia anemia NN cord-023095-4dannjjm 3242 20 , , , cord-023095-4dannjjm 3242 21 leucocytosis leucocytosis NNP cord-023095-4dannjjm 3242 22 and and CC cord-023095-4dannjjm 3242 23 presence presence NN cord-023095-4dannjjm 3242 24 of of IN cord-023095-4dannjjm 3242 25 spherocytes spherocyte NNS cord-023095-4dannjjm 3242 26 . . . cord-023095-4dannjjm 3243 1 The the DT cord-023095-4dannjjm 3243 2 definitive definitive JJ cord-023095-4dannjjm 3243 3 diagnostic diagnostic JJ cord-023095-4dannjjm 3243 4 procedure procedure NN cord-023095-4dannjjm 3243 5 is be VBZ cord-023095-4dannjjm 3243 6 the the DT cord-023095-4dannjjm 3243 7 Coomb Coomb NNP cord-023095-4dannjjm 3243 8 's 's POS cord-023095-4dannjjm 3243 9 test test NN cord-023095-4dannjjm 3243 10 ( ( -LRB- cord-023095-4dannjjm 3243 11 direct direct JJ cord-023095-4dannjjm 3243 12 antiglobulin antiglobulin NN cord-023095-4dannjjm 3243 13 test test NN cord-023095-4dannjjm 3243 14 , , , cord-023095-4dannjjm 3243 15 DAT DAT NNP cord-023095-4dannjjm 3243 16 ) ) -RRB- cord-023095-4dannjjm 3243 17 which which WDT cord-023095-4dannjjm 3243 18 is be VBZ cord-023095-4dannjjm 3243 19 known know VBN cord-023095-4dannjjm 3243 20 to to TO cord-023095-4dannjjm 3243 21 be be VB cord-023095-4dannjjm 3243 22 highly highly RB cord-023095-4dannjjm 3243 23 specific specific JJ cord-023095-4dannjjm 3243 24 but but CC cord-023095-4dannjjm 3243 25 lacks lack VBZ cord-023095-4dannjjm 3243 26 diagnostic diagnostic JJ cord-023095-4dannjjm 3243 27 sensitivity sensitivity NN cord-023095-4dannjjm 3243 28 . . . cord-023095-4dannjjm 3244 1 Direct direct JJ cord-023095-4dannjjm 3244 2 flow flow NN cord-023095-4dannjjm 3244 3 cytometric cytometric NN cord-023095-4dannjjm 3244 4 assay assay NN cord-023095-4dannjjm 3244 5 ( ( -LRB- cord-023095-4dannjjm 3244 6 FCA FCA NNP cord-023095-4dannjjm 3244 7 ) ) -RRB- cord-023095-4dannjjm 3244 8 for for IN cord-023095-4dannjjm 3244 9 IgG IgG NNP cord-023095-4dannjjm 3244 10 , , , cord-023095-4dannjjm 3244 11 IgM IgM NNP cord-023095-4dannjjm 3244 12 or or CC cord-023095-4dannjjm 3244 13 C3 C3 NNP cord-023095-4dannjjm 3244 14 coated coat VBN cord-023095-4dannjjm 3244 15 red red JJ cord-023095-4dannjjm 3244 16 blood blood NN cord-023095-4dannjjm 3244 17 cells cell NNS cord-023095-4dannjjm 3244 18 ( ( -LRB- cord-023095-4dannjjm 3244 19 RBCs rbc NNS cord-023095-4dannjjm 3244 20 ) ) -RRB- cord-023095-4dannjjm 3244 21 detection detection NN cord-023095-4dannjjm 3244 22 might may MD cord-023095-4dannjjm 3244 23 be be VB cord-023095-4dannjjm 3244 24 more more RBR cord-023095-4dannjjm 3244 25 sensitive sensitive JJ cord-023095-4dannjjm 3244 26 and and CC cord-023095-4dannjjm 3244 27 thus thus RB cord-023095-4dannjjm 3244 28 could could MD cord-023095-4dannjjm 3244 29 be be VB cord-023095-4dannjjm 3244 30 introduced introduce VBN cord-023095-4dannjjm 3244 31 as as IN cord-023095-4dannjjm 3244 32 an an DT cord-023095-4dannjjm 3244 33 alternative alternative JJ cord-023095-4dannjjm 3244 34 diagnostic diagnostic JJ cord-023095-4dannjjm 3244 35 tool tool NN cord-023095-4dannjjm 3244 36 . . . cord-023095-4dannjjm 3245 1 To to TO cord-023095-4dannjjm 3245 2 investigate investigate VB cord-023095-4dannjjm 3245 3 the the DT cord-023095-4dannjjm 3245 4 usefulness usefulness NN cord-023095-4dannjjm 3245 5 of of IN cord-023095-4dannjjm 3245 6 FCA FCA NNP cord-023095-4dannjjm 3245 7 for for IN cord-023095-4dannjjm 3245 8 IMHA IMHA NNP cord-023095-4dannjjm 3245 9 diagnosis diagnosis NN cord-023095-4dannjjm 3245 10 , , , cord-023095-4dannjjm 3245 11 evaluation evaluation NN cord-023095-4dannjjm 3245 12 of of IN cord-023095-4dannjjm 3245 13 IgG IgG NNP cord-023095-4dannjjm 3245 14 , , , cord-023095-4dannjjm 3245 15 IgM IgM NNP cord-023095-4dannjjm 3245 16 or or CC cord-023095-4dannjjm 3245 17 C3 C3 NNP cord-023095-4dannjjm 3245 18 coated coated JJ cord-023095-4dannjjm 3245 19 RBCs rbc NNS cord-023095-4dannjjm 3245 20 was be VBD cord-023095-4dannjjm 3245 21 performed perform VBN cord-023095-4dannjjm 3245 22 from from IN cord-023095-4dannjjm 3245 23 15 15 CD cord-023095-4dannjjm 3245 24 dogs dog NNS cord-023095-4dannjjm 3245 25 presented present VBN cord-023095-4dannjjm 3245 26 at at IN cord-023095-4dannjjm 3245 27 the the DT cord-023095-4dannjjm 3245 28 Veterinary Veterinary NNP cord-023095-4dannjjm 3245 29 Hospital Hospital NNP cord-023095-4dannjjm 3245 30 at at IN cord-023095-4dannjjm 3245 31 USP USP NNP cord-023095-4dannjjm 3245 32 that that WDT cord-023095-4dannjjm 3245 33 fulfilled fulfil VBD cord-023095-4dannjjm 3245 34 clinical clinical JJ cord-023095-4dannjjm 3245 35 and and CC cord-023095-4dannjjm 3245 36 hematological hematological JJ cord-023095-4dannjjm 3245 37 criteria criterion NNS cord-023095-4dannjjm 3245 38 for for IN cord-023095-4dannjjm 3245 39 IMHA IMHA NNP cord-023095-4dannjjm 3245 40 . . . cord-023095-4dannjjm 3246 1 Thirty thirty CD cord-023095-4dannjjm 3246 2 eight eight CD cord-023095-4dannjjm 3246 3 healthy healthy JJ cord-023095-4dannjjm 3246 4 dogs dog NNS cord-023095-4dannjjm 3246 5 were be VBD cord-023095-4dannjjm 3246 6 included include VBN cord-023095-4dannjjm 3246 7 as as IN cord-023095-4dannjjm 3246 8 controls control NNS cord-023095-4dannjjm 3246 9 . . . cord-023095-4dannjjm 3247 1 DAT DAT NNP cord-023095-4dannjjm 3247 2 was be VBD cord-023095-4dannjjm 3247 3 performed perform VBN cord-023095-4dannjjm 3247 4 with with IN cord-023095-4dannjjm 3247 5 polyvalent polyvalent JJ cord-023095-4dannjjm 3247 6 and and CC cord-023095-4dannjjm 3247 7 monovalent monovalent JJ cord-023095-4dannjjm 3247 8 anti anti JJ cord-023095-4dannjjm 3247 9 - - JJ cord-023095-4dannjjm 3247 10 dog dog JJ cord-023095-4dannjjm 3247 11 sera sera NNP cord-023095-4dannjjm 3247 12 with with IN cord-023095-4dannjjm 3247 13 twofold twofold JJ cord-023095-4dannjjm 3247 14 serial serial JJ cord-023095-4dannjjm 3247 15 dilutions dilution NNS cord-023095-4dannjjm 3247 16 of of IN cord-023095-4dannjjm 3247 17 each each DT cord-023095-4dannjjm 3247 18 one one CD cord-023095-4dannjjm 3247 19 , , , cord-023095-4dannjjm 3247 20 incubated incubate VBN cord-023095-4dannjjm 3247 21 with with IN cord-023095-4dannjjm 3247 22 2 2 CD cord-023095-4dannjjm 3247 23 % % NN cord-023095-4dannjjm 3247 24 RBCs rbc NNS cord-023095-4dannjjm 3247 25 suspension suspension NN cord-023095-4dannjjm 3247 26 at at IN cord-023095-4dannjjm 3247 27 371C 371c CD cord-023095-4dannjjm 3247 28 and and CC cord-023095-4dannjjm 3247 29 41C. 41c. CD cord-023095-4dannjjm 3247 30 For for IN cord-023095-4dannjjm 3247 31 FCA FCA NNP cord-023095-4dannjjm 3247 32 , , , cord-023095-4dannjjm 3247 33 2 2 CD cord-023095-4dannjjm 3247 34 % % NN cord-023095-4dannjjm 3247 35 RBCs rbc NNS cord-023095-4dannjjm 3247 36 from from IN cord-023095-4dannjjm 3247 37 anemic anemic JJ cord-023095-4dannjjm 3247 38 and and CC cord-023095-4dannjjm 3247 39 healthy healthy JJ cord-023095-4dannjjm 3247 40 dogs dog NNS cord-023095-4dannjjm 3247 41 were be VBD cord-023095-4dannjjm 3247 42 incubated incubate VBN cord-023095-4dannjjm 3247 43 with with IN cord-023095-4dannjjm 3247 44 FITC FITC NNP cord-023095-4dannjjm 3247 45 anti anti JJ cord-023095-4dannjjm 3247 46 - - JJ cord-023095-4dannjjm 3247 47 dog dog JJ cord-023095-4dannjjm 3247 48 IgG igg NN cord-023095-4dannjjm 3247 49 , , , cord-023095-4dannjjm 3247 50 anti anti JJ cord-023095-4dannjjm 3247 51 - - JJ cord-023095-4dannjjm 3247 52 dog dog JJ cord-023095-4dannjjm 3247 53 IgM IgM NNP cord-023095-4dannjjm 3247 54 and and CC cord-023095-4dannjjm 3247 55 anti anti JJ cord-023095-4dannjjm 3247 56 - - JJ cord-023095-4dannjjm 3247 57 dog dog NN cord-023095-4dannjjm 3247 58 C3 c3 NN cord-023095-4dannjjm 3247 59 and and CC cord-023095-4dannjjm 3247 60 submitted submit VBN cord-023095-4dannjjm 3247 61 to to TO cord-023095-4dannjjm 3247 62 flow flow VB cord-023095-4dannjjm 3247 63 cytometry cytometry NN cord-023095-4dannjjm 3247 64 evaluation evaluation NN cord-023095-4dannjjm 3247 65 . . . cord-023095-4dannjjm 3248 1 Specific specific JJ cord-023095-4dannjjm 3248 2 software software NN cord-023095-4dannjjm 3248 3 and and CC cord-023095-4dannjjm 3248 4 Mann Mann NNP cord-023095-4dannjjm 3248 5 Whitney Whitney NNP cord-023095-4dannjjm 3248 6 U U NNP cord-023095-4dannjjm 3248 7 test test NN cord-023095-4dannjjm 3248 8 were be VBD cord-023095-4dannjjm 3248 9 used use VBN cord-023095-4dannjjm 3248 10 for for IN cord-023095-4dannjjm 3248 11 data datum NNS cord-023095-4dannjjm 3248 12 analysis analysis NN cord-023095-4dannjjm 3248 13 . . . cord-023095-4dannjjm 3249 1 Five five CD cord-023095-4dannjjm 3249 2 dogs dog NNS cord-023095-4dannjjm 3249 3 showed show VBD cord-023095-4dannjjm 3249 4 positive positive JJ cord-023095-4dannjjm 3249 5 results result NNS cord-023095-4dannjjm 3249 6 for for IN cord-023095-4dannjjm 3249 7 DAT DAT NNP cord-023095-4dannjjm 3249 8 with with IN cord-023095-4dannjjm 3249 9 polyvalent polyvalent JJ cord-023095-4dannjjm 3249 10 Coombs Coombs NNP cord-023095-4dannjjm 3249 11 reagent reagent NN cord-023095-4dannjjm 3249 12 at at IN cord-023095-4dannjjm 3249 13 41C 41c CD cord-023095-4dannjjm 3249 14 ( ( -LRB- cord-023095-4dannjjm 3249 15 titer titer NN cord-023095-4dannjjm 3249 16 64 64 CD cord-023095-4dannjjm 3249 17 to to IN cord-023095-4dannjjm 3249 18 4096 4096 CD cord-023095-4dannjjm 3249 19 ) ) -RRB- cord-023095-4dannjjm 3249 20 and and CC cord-023095-4dannjjm 3249 21 371C 371C NNP cord-023095-4dannjjm 3249 22 ( ( -LRB- cord-023095-4dannjjm 3249 23 titer titer NN cord-023095-4dannjjm 3249 24 64 64 CD cord-023095-4dannjjm 3249 25 to to IN cord-023095-4dannjjm 3249 26 2048 2048 CD cord-023095-4dannjjm 3249 27 ) ) -RRB- cord-023095-4dannjjm 3249 28 but but CC cord-023095-4dannjjm 3249 29 only only RB cord-023095-4dannjjm 3249 30 three three CD cord-023095-4dannjjm 3249 31 of of IN cord-023095-4dannjjm 3249 32 them -PRON- PRP cord-023095-4dannjjm 3249 33 had have VBD cord-023095-4dannjjm 3249 34 agglutination agglutination NN cord-023095-4dannjjm 3249 35 titer titer NN cord-023095-4dannjjm 3249 36 for for IN cord-023095-4dannjjm 3249 37 anti anti JJ cord-023095-4dannjjm 3249 38 - - JJ cord-023095-4dannjjm 3249 39 IgG igg NN cord-023095-4dannjjm 3249 40 at at IN cord-023095-4dannjjm 3249 41 4 4 CD cord-023095-4dannjjm 3249 42 0 0 CD cord-023095-4dannjjm 3249 43 C c NN cord-023095-4dannjjm 3249 44 ( ( -LRB- cord-023095-4dannjjm 3249 45 1024 1024 CD cord-023095-4dannjjm 3249 46 to to IN cord-023095-4dannjjm 3249 47 8192 8192 CD cord-023095-4dannjjm 3249 48 ) ) -RRB- cord-023095-4dannjjm 3249 49 and and CC cord-023095-4dannjjm 3249 50 371C 371C NNP cord-023095-4dannjjm 3249 51 ( ( -LRB- cord-023095-4dannjjm 3249 52 512 512 CD cord-023095-4dannjjm 3249 53 to to IN cord-023095-4dannjjm 3249 54 4096 4096 CD cord-023095-4dannjjm 3249 55 ) ) -RRB- cord-023095-4dannjjm 3249 56 . . . cord-023095-4dannjjm 3250 1 No no DT cord-023095-4dannjjm 3250 2 positive positive JJ cord-023095-4dannjjm 3250 3 results result NNS cord-023095-4dannjjm 3250 4 were be VBD cord-023095-4dannjjm 3250 5 observed observe VBN cord-023095-4dannjjm 3250 6 for for IN cord-023095-4dannjjm 3250 7 anti anti JJ cord-023095-4dannjjm 3250 8 - - JJ cord-023095-4dannjjm 3250 9 IgM igm JJ cord-023095-4dannjjm 3250 10 and and CC cord-023095-4dannjjm 3250 11 anti anti JJ cord-023095-4dannjjm 3250 12 - - JJ cord-023095-4dannjjm 3250 13 C3 c3 JJ cord-023095-4dannjjm 3250 14 DAT DAT NNP cord-023095-4dannjjm 3250 15 . . . cord-023095-4dannjjm 3251 1 By by IN cord-023095-4dannjjm 3251 2 FC FC NNP cord-023095-4dannjjm 3251 3 , , , cord-023095-4dannjjm 3251 4 percentage percentage NN cord-023095-4dannjjm 3251 5 of of IN cord-023095-4dannjjm 3251 6 IgG IgG NNP cord-023095-4dannjjm 3251 7 , , , cord-023095-4dannjjm 3251 8 IgM IgM NNP cord-023095-4dannjjm 3251 9 and and CC cord-023095-4dannjjm 3251 10 C3 C3 NNP cord-023095-4dannjjm 3251 11 coated coated JJ cord-023095-4dannjjm 3251 12 RBCs rbc NNS cord-023095-4dannjjm 3251 13 in in IN cord-023095-4dannjjm 3251 14 normal normal JJ cord-023095-4dannjjm 3251 15 and and CC cord-023095-4dannjjm 3251 16 anemic anemic JJ cord-023095-4dannjjm 3251 17 dogs dog NNS cord-023095-4dannjjm 3251 18 were be VBD cord-023095-4dannjjm 3251 19 , , , cord-023095-4dannjjm 3251 20 respectively respectively RB cord-023095-4dannjjm 3251 21 , , , cord-023095-4dannjjm 3251 22 1,18 1,18 CD cord-023095-4dannjjm 3251 23 % % NN cord-023095-4dannjjm 3251 24 and and CC cord-023095-4dannjjm 3251 25 17,11 17,11 CD cord-023095-4dannjjm 3251 26 % % NN cord-023095-4dannjjm 3251 27 ( ( -LRB- cord-023095-4dannjjm 3251 28 p p NN cord-023095-4dannjjm 3251 29 o o NN cord-023095-4dannjjm 3251 30 0,001 0,001 CD cord-023095-4dannjjm 3251 31 ) ) -RRB- cord-023095-4dannjjm 3251 32 ; ; : cord-023095-4dannjjm 3251 33 1,15 1,15 CD cord-023095-4dannjjm 3251 34 % % NN cord-023095-4dannjjm 3251 35 and and CC cord-023095-4dannjjm 3251 36 21,29 21,29 CD cord-023095-4dannjjm 3251 37 % % NN cord-023095-4dannjjm 3251 38 ( ( -LRB- cord-023095-4dannjjm 3251 39 p p NN cord-023095-4dannjjm 3251 40 o o NN cord-023095-4dannjjm 3251 41 0,001 0,001 CD cord-023095-4dannjjm 3251 42 ) ) -RRB- cord-023095-4dannjjm 3251 43 ; ; : cord-023095-4dannjjm 3251 44 0,66 0,66 CD cord-023095-4dannjjm 3251 45 % % NN cord-023095-4dannjjm 3251 46 and and CC cord-023095-4dannjjm 3251 47 6,99 6,99 CD cord-023095-4dannjjm 3251 48 % % NN cord-023095-4dannjjm 3252 1 ( ( -LRB- cord-023095-4dannjjm 3252 2 p p NN cord-023095-4dannjjm 3252 3 o o NN cord-023095-4dannjjm 3252 4 0,001 0,001 CD cord-023095-4dannjjm 3252 5 ) ) -RRB- cord-023095-4dannjjm 3252 6 . . . cord-023095-4dannjjm 3253 1 IgG IgG NNP cord-023095-4dannjjm 3253 2 coated coat VBD cord-023095-4dannjjm 3253 3 RBCs rbc NNS cord-023095-4dannjjm 3253 4 percentage percentage NN cord-023095-4dannjjm 3253 5 were be VBD cord-023095-4dannjjm 3253 6 higher high JJR cord-023095-4dannjjm 3253 7 in in IN cord-023095-4dannjjm 3253 8 dogs dog NNS cord-023095-4dannjjm 3253 9 showing show VBG cord-023095-4dannjjm 3253 10 DAT DAT NNP cord-023095-4dannjjm 3253 11 positive positive JJ cord-023095-4dannjjm 3253 12 results result NNS cord-023095-4dannjjm 3253 13 ( ( -LRB- cord-023095-4dannjjm 3253 14 min min NN cord-023095-4dannjjm 3253 15 . . . cord-023095-4dannjjm 3253 16 33,94 33,94 CD cord-023095-4dannjjm 3253 17 % % NN cord-023095-4dannjjm 3253 18 ; ; : cord-023095-4dannjjm 3253 19 max max NNP cord-023095-4dannjjm 3253 20 . . . cord-023095-4dannjjm 3254 1 99,96 99,96 CD cord-023095-4dannjjm 3254 2 % % NN cord-023095-4dannjjm 3254 3 ; ; : cord-023095-4dannjjm 3254 4 median median JJ cord-023095-4dannjjm 3254 5 54,25 54,25 CD cord-023095-4dannjjm 3254 6 % % NN cord-023095-4dannjjm 3254 7 ) ) -RRB- cord-023095-4dannjjm 3254 8 . . . cord-023095-4dannjjm 3255 1 Direct direct JJ cord-023095-4dannjjm 3255 2 flow flow NN cord-023095-4dannjjm 3255 3 cytometric cytometric NN cord-023095-4dannjjm 3255 4 erythrocyte erythrocyte NN cord-023095-4dannjjm 3255 5 immunofluorescence immunofluorescence NN cord-023095-4dannjjm 3255 6 assay assay NN cord-023095-4dannjjm 3255 7 is be VBZ cord-023095-4dannjjm 3255 8 more more RBR cord-023095-4dannjjm 3255 9 sensitive sensitive JJ cord-023095-4dannjjm 3255 10 than than IN cord-023095-4dannjjm 3255 11 DAT DAT NNP cord-023095-4dannjjm 3255 12 for for IN cord-023095-4dannjjm 3255 13 detection detection NN cord-023095-4dannjjm 3255 14 of of IN cord-023095-4dannjjm 3255 15 antibodies antibody NNS cord-023095-4dannjjm 3255 16 coated coat VBD cord-023095-4dannjjm 3255 17 RBC RBC NNP cord-023095-4dannjjm 3255 18 in in IN cord-023095-4dannjjm 3255 19 anemic anemic JJ cord-023095-4dannjjm 3255 20 dogs dog NNS cord-023095-4dannjjm 3255 21 and and CC cord-023095-4dannjjm 3255 22 may may MD cord-023095-4dannjjm 3255 23 provide provide VB cord-023095-4dannjjm 3255 24 quantitative quantitative JJ cord-023095-4dannjjm 3255 25 data datum NNS cord-023095-4dannjjm 3255 26 useful useful JJ cord-023095-4dannjjm 3255 27 for for IN cord-023095-4dannjjm 3255 28 laboratorial laboratorial JJ cord-023095-4dannjjm 3255 29 diagnosis diagnosis NN cord-023095-4dannjjm 3255 30 of of IN cord-023095-4dannjjm 3255 31 IMzHA IMzHA NNP cord-023095-4dannjjm 3255 32 . . . cord-023095-4dannjjm 3256 1 Bone bone NN cord-023095-4dannjjm 3256 2 marrow marrow NN cord-023095-4dannjjm 3256 3 aspirates aspirate NNS cord-023095-4dannjjm 3256 4 from from IN cord-023095-4dannjjm 3256 5 cats cat NNS cord-023095-4dannjjm 3256 6 are be VBP cord-023095-4dannjjm 3256 7 typically typically RB cord-023095-4dannjjm 3256 8 obtained obtain VBN cord-023095-4dannjjm 3256 9 from from IN cord-023095-4dannjjm 3256 10 the the DT cord-023095-4dannjjm 3256 11 ilium ilium NNP cord-023095-4dannjjm 3256 12 , , , cord-023095-4dannjjm 3256 13 humerus humerus NN cord-023095-4dannjjm 3256 14 or or CC cord-023095-4dannjjm 3256 15 femur femur NN cord-023095-4dannjjm 3256 16 , , , cord-023095-4dannjjm 3256 17 but but CC cord-023095-4dannjjm 3256 18 may may MD cord-023095-4dannjjm 3256 19 be be VB cord-023095-4dannjjm 3256 20 difficult difficult JJ cord-023095-4dannjjm 3256 21 to to TO cord-023095-4dannjjm 3256 22 obtain obtain VB cord-023095-4dannjjm 3256 23 and/or and/or CC cord-023095-4dannjjm 3256 24 of of IN cord-023095-4dannjjm 3256 25 poor poor JJ cord-023095-4dannjjm 3256 26 quality quality NN cord-023095-4dannjjm 3256 27 . . . cord-023095-4dannjjm 3257 1 In in IN cord-023095-4dannjjm 3257 2 this this DT cord-023095-4dannjjm 3257 3 study study NN cord-023095-4dannjjm 3257 4 the the DT cord-023095-4dannjjm 3257 5 feasibility feasibility NN cord-023095-4dannjjm 3257 6 , , , cord-023095-4dannjjm 3257 7 safety safety NN cord-023095-4dannjjm 3257 8 , , , cord-023095-4dannjjm 3257 9 and and CC cord-023095-4dannjjm 3257 10 nature nature NN cord-023095-4dannjjm 3257 11 of of IN cord-023095-4dannjjm 3257 12 sternal sternal JJ cord-023095-4dannjjm 3257 13 aspiration aspiration NN cord-023095-4dannjjm 3257 14 in in IN cord-023095-4dannjjm 3257 15 cats cat NNS cord-023095-4dannjjm 3257 16 was be VBD cord-023095-4dannjjm 3257 17 investigated investigate VBN cord-023095-4dannjjm 3257 18 . . . cord-023095-4dannjjm 3258 1 Under under IN cord-023095-4dannjjm 3258 2 general general JJ cord-023095-4dannjjm 3258 3 anesthesia anesthesia NN cord-023095-4dannjjm 3258 4 , , , cord-023095-4dannjjm 3258 5 bone bone NN cord-023095-4dannjjm 3258 6 marrow marrow NN cord-023095-4dannjjm 3258 7 aspirates aspirate NNS cord-023095-4dannjjm 3258 8 were be VBD cord-023095-4dannjjm 3258 9 obtained obtain VBN cord-023095-4dannjjm 3258 10 in in IN cord-023095-4dannjjm 3258 11 a a DT cord-023095-4dannjjm 3258 12 randomized randomized JJ cord-023095-4dannjjm 3258 13 order order NN cord-023095-4dannjjm 3258 14 by by IN cord-023095-4dannjjm 3258 15 a a DT cord-023095-4dannjjm 3258 16 single single JJ cord-023095-4dannjjm 3258 17 investigator investigator NN cord-023095-4dannjjm 3258 18 from from IN cord-023095-4dannjjm 3258 19 the the DT cord-023095-4dannjjm 3258 20 sternum sternum NN cord-023095-4dannjjm 3258 21 and and CC cord-023095-4dannjjm 3258 22 ilium ilium NN cord-023095-4dannjjm 3258 23 of of IN cord-023095-4dannjjm 3258 24 10 10 CD cord-023095-4dannjjm 3258 25 healthy healthy JJ cord-023095-4dannjjm 3258 26 cats cat NNS cord-023095-4dannjjm 3258 27 weighing weigh VBG cord-023095-4dannjjm 3258 28 3.4 3.4 CD cord-023095-4dannjjm 3258 29 - - HYPH cord-023095-4dannjjm 3258 30 8.4 8.4 CD cord-023095-4dannjjm 3258 31 kg kg NNS cord-023095-4dannjjm 3258 32 , , , cord-023095-4dannjjm 3258 33 with with IN cord-023095-4dannjjm 3258 34 body body NN cord-023095-4dannjjm 3258 35 condition condition NN cord-023095-4dannjjm 3258 36 scores score NNS cord-023095-4dannjjm 3258 37 of of IN cord-023095-4dannjjm 3258 38 5 5 CD cord-023095-4dannjjm 3258 39 - - SYM cord-023095-4dannjjm 3258 40 9 9 CD cord-023095-4dannjjm 3258 41 ( ( -LRB- cord-023095-4dannjjm 3258 42 on on IN cord-023095-4dannjjm 3258 43 a a DT cord-023095-4dannjjm 3258 44 scale scale NN cord-023095-4dannjjm 3258 45 of of IN cord-023095-4dannjjm 3258 46 1 1 CD cord-023095-4dannjjm 3258 47 - - SYM cord-023095-4dannjjm 3258 48 9 9 CD cord-023095-4dannjjm 3258 49 ) ) -RRB- cord-023095-4dannjjm 3258 50 . . . cord-023095-4dannjjm 3259 1 For for IN cord-023095-4dannjjm 3259 2 sternal sternal JJ cord-023095-4dannjjm 3259 3 aspirates aspirate NNS cord-023095-4dannjjm 3259 4 , , , cord-023095-4dannjjm 3259 5 cats cat NNS cord-023095-4dannjjm 3259 6 were be VBD cord-023095-4dannjjm 3259 7 positioned position VBN cord-023095-4dannjjm 3259 8 in in IN cord-023095-4dannjjm 3259 9 sternal sternal JJ cord-023095-4dannjjm 3259 10 recumbency recumbency NN cord-023095-4dannjjm 3259 11 and and CC cord-023095-4dannjjm 3259 12 a a DT cord-023095-4dannjjm 3259 13 1-inch 1-inch CD cord-023095-4dannjjm 3259 14 , , , cord-023095-4dannjjm 3259 15 22 22 CD cord-023095-4dannjjm 3259 16 - - SYM cord-023095-4dannjjm 3259 17 23 23 CD cord-023095-4dannjjm 3259 18 ga ga NNP cord-023095-4dannjjm 3259 19 hypodermic hypodermic NNP cord-023095-4dannjjm 3259 20 needle needle NN cord-023095-4dannjjm 3259 21 attached attach VBN cord-023095-4dannjjm 3259 22 to to IN cord-023095-4dannjjm 3259 23 a a DT cord-023095-4dannjjm 3259 24 12cc 12cc JJ cord-023095-4dannjjm 3259 25 syringe syringe NN cord-023095-4dannjjm 3259 26 was be VBD cord-023095-4dannjjm 3259 27 inserted insert VBN cord-023095-4dannjjm 3259 28 into into IN cord-023095-4dannjjm 3259 29 the the DT cord-023095-4dannjjm 3259 30 cranial cranial JJ cord-023095-4dannjjm 3259 31 manubrium manubrium NN cord-023095-4dannjjm 3259 32 and and CC cord-023095-4dannjjm 3259 33 directed direct VBD cord-023095-4dannjjm 3259 34 caudally caudally RB cord-023095-4dannjjm 3259 35 along along IN cord-023095-4dannjjm 3259 36 the the DT cord-023095-4dannjjm 3259 37 long long JJ cord-023095-4dannjjm 3259 38 axis axis NN cord-023095-4dannjjm 3259 39 of of IN cord-023095-4dannjjm 3259 40 the the DT cord-023095-4dannjjm 3259 41 sternum sternum NN cord-023095-4dannjjm 3259 42 . . . cord-023095-4dannjjm 3260 1 Aspirates Aspirates NNP cord-023095-4dannjjm 3260 2 were be VBD cord-023095-4dannjjm 3260 3 also also RB cord-023095-4dannjjm 3260 4 obtained obtain VBN cord-023095-4dannjjm 3260 5 from from IN cord-023095-4dannjjm 3260 6 the the DT cord-023095-4dannjjm 3260 7 right right NNP cord-023095-4dannjjm 3260 8 iliac iliac NNP cord-023095-4dannjjm 3260 9 crest crest NN cord-023095-4dannjjm 3260 10 using use VBG cord-023095-4dannjjm 3260 11 an an DT cord-023095-4dannjjm 3260 12 18 18 CD cord-023095-4dannjjm 3260 13 ga ga NNP cord-023095-4dannjjm 3260 14 Illinois Illinois NNP cord-023095-4dannjjm 3260 15 needle needle NN cord-023095-4dannjjm 3260 16 attached attach VBN cord-023095-4dannjjm 3260 17 to to IN cord-023095-4dannjjm 3260 18 a a DT cord-023095-4dannjjm 3260 19 12cc 12cc JJ cord-023095-4dannjjm 3260 20 syringe syringe NN cord-023095-4dannjjm 3260 21 . . . cord-023095-4dannjjm 3261 1 Difficulty difficulty NN cord-023095-4dannjjm 3261 2 of of IN cord-023095-4dannjjm 3261 3 site site NN cord-023095-4dannjjm 3261 4 localization localization NN cord-023095-4dannjjm 3261 5 , , , cord-023095-4dannjjm 3261 6 needle needle NN cord-023095-4dannjjm 3261 7 insertion insertion NN cord-023095-4dannjjm 3261 8 and and CC cord-023095-4dannjjm 3261 9 advancement advancement NN cord-023095-4dannjjm 3261 10 , , , cord-023095-4dannjjm 3261 11 and and CC cord-023095-4dannjjm 3261 12 specimen specimen JJ cord-023095-4dannjjm 3261 13 aspiration aspiration NN cord-023095-4dannjjm 3261 14 , , , cord-023095-4dannjjm 3261 15 were be VBD cord-023095-4dannjjm 3261 16 scored score VBN cord-023095-4dannjjm 3261 17 from from IN cord-023095-4dannjjm 3261 18 1 1 CD cord-023095-4dannjjm 3261 19 ( ( -LRB- cord-023095-4dannjjm 3261 20 easiest easy JJS cord-023095-4dannjjm 3261 21 ) ) -RRB- cord-023095-4dannjjm 3261 22 to to IN cord-023095-4dannjjm 3261 23 5 5 CD cord-023095-4dannjjm 3261 24 ( ( -LRB- cord-023095-4dannjjm 3261 25 hardest hard RBS cord-023095-4dannjjm 3261 26 ) ) -RRB- cord-023095-4dannjjm 3261 27 . . . cord-023095-4dannjjm 3262 1 Bone bone NN cord-023095-4dannjjm 3262 2 marrow marrow NN cord-023095-4dannjjm 3262 3 smears smear NNS cord-023095-4dannjjm 3262 4 were be VBD cord-023095-4dannjjm 3262 5 prepared prepare VBN cord-023095-4dannjjm 3262 6 by by IN cord-023095-4dannjjm 3262 7 one one CD cord-023095-4dannjjm 3262 8 investigator investigator NN cord-023095-4dannjjm 3262 9 and and CC cord-023095-4dannjjm 3262 10 reviewed review VBN cord-023095-4dannjjm 3262 11 by by IN cord-023095-4dannjjm 3262 12 a a DT cord-023095-4dannjjm 3262 13 pathologist pathologist NN cord-023095-4dannjjm 3262 14 blinded blind VBN cord-023095-4dannjjm 3262 15 to to IN cord-023095-4dannjjm 3262 16 aspiration aspiration NN cord-023095-4dannjjm 3262 17 site site NN cord-023095-4dannjjm 3262 18 and and CC cord-023095-4dannjjm 3262 19 cat cat NN cord-023095-4dannjjm 3262 20 . . . cord-023095-4dannjjm 3263 1 Sample sample JJ cord-023095-4dannjjm 3263 2 quality quality NN cord-023095-4dannjjm 3263 3 was be VBD cord-023095-4dannjjm 3263 4 scored score VBN cord-023095-4dannjjm 3263 5 from from IN cord-023095-4dannjjm 3263 6 0 0 NFP cord-023095-4dannjjm 3263 7 ( ( -LRB- cord-023095-4dannjjm 3263 8 no no DT cord-023095-4dannjjm 3263 9 marrow marrow NN cord-023095-4dannjjm 3263 10 particles particle NNS cord-023095-4dannjjm 3263 11 ) ) -RRB- cord-023095-4dannjjm 3263 12 to to IN cord-023095-4dannjjm 3263 13 5 5 CD cord-023095-4dannjjm 3263 14 ( ( -LRB- cord-023095-4dannjjm 3263 15 excellent excellent NN cord-023095-4dannjjm 3263 16 ) ) -RRB- cord-023095-4dannjjm 3263 17 based base VBN cord-023095-4dannjjm 3263 18 on on IN cord-023095-4dannjjm 3263 19 the the DT cord-023095-4dannjjm 3263 20 number number NN cord-023095-4dannjjm 3263 21 of of IN cord-023095-4dannjjm 3263 22 wellsmeared wellsmeare VBN cord-023095-4dannjjm 3263 23 marrow marrow NN cord-023095-4dannjjm 3263 24 particles particle NNS cord-023095-4dannjjm 3263 25 on on IN cord-023095-4dannjjm 3263 26 the the DT cord-023095-4dannjjm 3263 27 slide slide NN cord-023095-4dannjjm 3263 28 . . . cord-023095-4dannjjm 3264 1 Particle particle NN cord-023095-4dannjjm 3264 2 cellularity cellularity NN cord-023095-4dannjjm 3264 3 was be VBD cord-023095-4dannjjm 3264 4 scored score VBN cord-023095-4dannjjm 3264 5 from from IN cord-023095-4dannjjm 3264 6 1 1 CD cord-023095-4dannjjm 3264 7 ( ( -LRB- cord-023095-4dannjjm 3264 8 4 4 CD cord-023095-4dannjjm 3264 9 75 75 CD cord-023095-4dannjjm 3264 10 % % NN cord-023095-4dannjjm 3264 11 fat fat NN cord-023095-4dannjjm 3264 12 ) ) -RRB- cord-023095-4dannjjm 3264 13 to to IN cord-023095-4dannjjm 3264 14 3 3 CD cord-023095-4dannjjm 3264 15 ( ( -LRB- cord-023095-4dannjjm 3264 16 o o NN cord-023095-4dannjjm 3264 17 25 25 CD cord-023095-4dannjjm 3264 18 % % NN cord-023095-4dannjjm 3264 19 fat fat NN cord-023095-4dannjjm 3264 20 ) ) -RRB- cord-023095-4dannjjm 3264 21 . . . cord-023095-4dannjjm 3265 1 Post post NN cord-023095-4dannjjm 3265 2 - - NN cord-023095-4dannjjm 3265 3 procedure procedure NN cord-023095-4dannjjm 3265 4 , , , cord-023095-4dannjjm 3265 5 cats cat NNS cord-023095-4dannjjm 3265 6 were be VBD cord-023095-4dannjjm 3265 7 treated treat VBN cord-023095-4dannjjm 3265 8 with with IN cord-023095-4dannjjm 3265 9 tramadol tramadol NN cord-023095-4dannjjm 3265 10 ( ( -LRB- cord-023095-4dannjjm 3265 11 4 4 CD cord-023095-4dannjjm 3265 12 - - SYM cord-023095-4dannjjm 3265 13 5 5 CD cord-023095-4dannjjm 3265 14 mg mg NNP cord-023095-4dannjjm 3265 15 / / SYM cord-023095-4dannjjm 3265 16 kg kg NNP cord-023095-4dannjjm 3265 17 , , , cord-023095-4dannjjm 3265 18 PO PO NNP cord-023095-4dannjjm 3265 19 , , , cord-023095-4dannjjm 3265 20 q12h q12h CD cord-023095-4dannjjm 3265 21 ) ) -RRB- cord-023095-4dannjjm 3265 22 for for IN cord-023095-4dannjjm 3265 23 3 3 CD cord-023095-4dannjjm 3265 24 days day NNS cord-023095-4dannjjm 3265 25 , , , cord-023095-4dannjjm 3265 26 and and CC cord-023095-4dannjjm 3265 27 assessed assess VBN cord-023095-4dannjjm 3265 28 for for IN cord-023095-4dannjjm 3265 29 post post JJ cord-023095-4dannjjm 3265 30 - - JJ cord-023095-4dannjjm 3265 31 biopsy biopsy JJ cord-023095-4dannjjm 3265 32 pain pain NN cord-023095-4dannjjm 3265 33 ( ( -LRB- cord-023095-4dannjjm 3265 34 Colorado Colorado NNP cord-023095-4dannjjm 3265 35 State State NNP cord-023095-4dannjjm 3265 36 University University NNP cord-023095-4dannjjm 3265 37 Feline Feline NNP cord-023095-4dannjjm 3265 38 Acute acute JJ cord-023095-4dannjjm 3265 39 Pain pain NN cord-023095-4dannjjm 3265 40 Scale scale NN cord-023095-4dannjjm 3265 41 , , , cord-023095-4dannjjm 3265 42 range range VBP cord-023095-4dannjjm 3265 43 0 0 NFP cord-023095-4dannjjm 3265 44 [ [ -LRB- cord-023095-4dannjjm 3265 45 no no DT cord-023095-4dannjjm 3265 46 pain pain NN cord-023095-4dannjjm 3265 47 ] ] -RRB- cord-023095-4dannjjm 3265 48 -4 -4 FW cord-023095-4dannjjm 3265 49 [ [ -LRB- cord-023095-4dannjjm 3265 50 maximum maximum NN cord-023095-4dannjjm 3265 51 ] ] -RRB- cord-023095-4dannjjm 3265 52 ) ) -RRB- cord-023095-4dannjjm 3265 53 and and CC cord-023095-4dannjjm 3265 54 site site NN cord-023095-4dannjjm 3265 55 swelling swelling NN cord-023095-4dannjjm 3265 56 ( ( -LRB- cord-023095-4dannjjm 3265 57 range range NN cord-023095-4dannjjm 3265 58 0 0 NFP cord-023095-4dannjjm 3265 59 [ [ -LRB- cord-023095-4dannjjm 3265 60 none none NN cord-023095-4dannjjm 3265 61 ] ] -RRB- cord-023095-4dannjjm 3265 62 -3 -3 NNP cord-023095-4dannjjm 3265 63 [ [ -LRB- cord-023095-4dannjjm 3265 64 marked mark VBN cord-023095-4dannjjm 3265 65 ] ] -RRB- cord-023095-4dannjjm 3265 66 ) ) -RRB- cord-023095-4dannjjm 3265 67 . . . cord-023095-4dannjjm 3266 1 Data datum NNS cord-023095-4dannjjm 3266 2 were be VBD cord-023095-4dannjjm 3266 3 analyzed analyze VBN cord-023095-4dannjjm 3266 4 by by IN cord-023095-4dannjjm 3266 5 ANCOVA ANCOVA NNP cord-023095-4dannjjm 3266 6 accounting accounting NN cord-023095-4dannjjm 3266 7 for for IN cord-023095-4dannjjm 3266 8 effects effect NNS cord-023095-4dannjjm 3266 9 of of IN cord-023095-4dannjjm 3266 10 weight weight NN cord-023095-4dannjjm 3266 11 and and CC cord-023095-4dannjjm 3266 12 body body NN cord-023095-4dannjjm 3266 13 condition condition NN cord-023095-4dannjjm 3266 14 score score NN cord-023095-4dannjjm 3266 15 . . . cord-023095-4dannjjm 3267 1 Pneumothorax pneumothorax NN cord-023095-4dannjjm 3267 2 was be VBD cord-023095-4dannjjm 3267 3 not not RB cord-023095-4dannjjm 3267 4 identified identify VBN cord-023095-4dannjjm 3267 5 . . . cord-023095-4dannjjm 3268 1 It -PRON- PRP cord-023095-4dannjjm 3268 2 was be VBD cord-023095-4dannjjm 3268 3 significantly significantly RB cord-023095-4dannjjm 3268 4 easier easy JJR cord-023095-4dannjjm 3268 5 to to TO cord-023095-4dannjjm 3268 6 perform perform VB cord-023095-4dannjjm 3268 7 sternal sternal JJ cord-023095-4dannjjm 3268 8 than than IN cord-023095-4dannjjm 3268 9 iliac iliac JJ cord-023095-4dannjjm 3268 10 aspiration aspiration NN cord-023095-4dannjjm 3268 11 , , , cord-023095-4dannjjm 3268 12 but but CC cord-023095-4dannjjm 3268 13 the the DT cord-023095-4dannjjm 3268 14 quality quality NN cord-023095-4dannjjm 3268 15 of of IN cord-023095-4dannjjm 3268 16 the the DT cord-023095-4dannjjm 3268 17 sample sample NN cord-023095-4dannjjm 3268 18 was be VBD cord-023095-4dannjjm 3268 19 significantly significantly RB cord-023095-4dannjjm 3268 20 better well JJR cord-023095-4dannjjm 3268 21 for for IN cord-023095-4dannjjm 3268 22 iliac iliac NN cord-023095-4dannjjm 3268 23 than than IN cord-023095-4dannjjm 3268 24 for for IN cord-023095-4dannjjm 3268 25 sternal sternal JJ cord-023095-4dannjjm 3268 26 aspirates aspirate NNS cord-023095-4dannjjm 3268 27 . . . cord-023095-4dannjjm 3269 1 Because because IN cord-023095-4dannjjm 3269 2 of of IN cord-023095-4dannjjm 3269 3 limitations limitation NNS cord-023095-4dannjjm 3269 4 due due JJ cord-023095-4dannjjm 3269 5 to to TO cord-023095-4dannjjm 3269 6 sample sample VB cord-023095-4dannjjm 3269 7 quality quality NN cord-023095-4dannjjm 3269 8 , , , cord-023095-4dannjjm 3269 9 bone bone NN cord-023095-4dannjjm 3269 10 marrow marrow NN cord-023095-4dannjjm 3269 11 morphology morphology NN cord-023095-4dannjjm 3269 12 in in IN cord-023095-4dannjjm 3269 13 sternal sternal JJ cord-023095-4dannjjm 3269 14 samples sample NNS cord-023095-4dannjjm 3269 15 could could MD cord-023095-4dannjjm 3269 16 not not RB cord-023095-4dannjjm 3269 17 be be VB cord-023095-4dannjjm 3269 18 compared compare VBN cord-023095-4dannjjm 3269 19 to to IN cord-023095-4dannjjm 3269 20 iliac iliac NN cord-023095-4dannjjm 3269 21 samples sample NNS cord-023095-4dannjjm 3269 22 in in IN cord-023095-4dannjjm 3269 23 all all DT cord-023095-4dannjjm 3269 24 cats cat NNS cord-023095-4dannjjm 3269 25 . . . cord-023095-4dannjjm 3270 1 For for IN cord-023095-4dannjjm 3270 2 samples sample NNS cord-023095-4dannjjm 3270 3 that that WDT cord-023095-4dannjjm 3270 4 could could MD cord-023095-4dannjjm 3270 5 be be VB cord-023095-4dannjjm 3270 6 compared compare VBN cord-023095-4dannjjm 3270 7 , , , cord-023095-4dannjjm 3270 8 cellularity cellularity NN cord-023095-4dannjjm 3270 9 was be VBD cord-023095-4dannjjm 3270 10 identical identical JJ cord-023095-4dannjjm 3270 11 for for IN cord-023095-4dannjjm 3270 12 sternal sternal JJ cord-023095-4dannjjm 3270 13 and and CC cord-023095-4dannjjm 3270 14 iliac iliac JJ cord-023095-4dannjjm 3270 15 samples sample NNS cord-023095-4dannjjm 3270 16 from from IN cord-023095-4dannjjm 3270 17 1 1 CD cord-023095-4dannjjm 3270 18 cat cat NN cord-023095-4dannjjm 3270 19 but but CC cord-023095-4dannjjm 3270 20 underestimated underestimate VBN cord-023095-4dannjjm 3270 21 in in IN cord-023095-4dannjjm 3270 22 the the DT cord-023095-4dannjjm 3270 23 sternal sternal JJ cord-023095-4dannjjm 3270 24 sample sample NN cord-023095-4dannjjm 3270 25 from from IN cord-023095-4dannjjm 3270 26 another another DT cord-023095-4dannjjm 3270 27 cat cat NN cord-023095-4dannjjm 3270 28 . . . cord-023095-4dannjjm 3271 1 Myeloid myeloid NN cord-023095-4dannjjm 3271 2 : : : cord-023095-4dannjjm 3271 3 erythroid erythroid NN cord-023095-4dannjjm 3271 4 ratios ratio NNS cord-023095-4dannjjm 3271 5 and and CC cord-023095-4dannjjm 3271 6 lymphocyte lymphocyte NN cord-023095-4dannjjm 3271 7 numbers number NNS cord-023095-4dannjjm 3271 8 were be VBD cord-023095-4dannjjm 3271 9 the the DT cord-023095-4dannjjm 3271 10 same same JJ cord-023095-4dannjjm 3271 11 for for IN cord-023095-4dannjjm 3271 12 sternal sternal JJ cord-023095-4dannjjm 3271 13 and and CC cord-023095-4dannjjm 3271 14 iliac iliac JJ cord-023095-4dannjjm 3271 15 samples sample NNS cord-023095-4dannjjm 3271 16 in in IN cord-023095-4dannjjm 3271 17 2 2 CD cord-023095-4dannjjm 3271 18 and and CC cord-023095-4dannjjm 3271 19 3 3 CD cord-023095-4dannjjm 3271 20 cats cat NNS cord-023095-4dannjjm 3271 21 , , , cord-023095-4dannjjm 3271 22 respectively respectively RB cord-023095-4dannjjm 3271 23 . . . cord-023095-4dannjjm 3272 1 Megakaryocyte Megakaryocyte NNP cord-023095-4dannjjm 3272 2 numbers number NNS cord-023095-4dannjjm 3272 3 were be VBD cord-023095-4dannjjm 3272 4 the the DT cord-023095-4dannjjm 3272 5 same same JJ cord-023095-4dannjjm 3272 6 in in IN cord-023095-4dannjjm 3272 7 one one CD cord-023095-4dannjjm 3272 8 sample sample NN cord-023095-4dannjjm 3272 9 , , , cord-023095-4dannjjm 3272 10 less less JJR cord-023095-4dannjjm 3272 11 in in IN cord-023095-4dannjjm 3272 12 sternal sternal JJ cord-023095-4dannjjm 3272 13 samples sample NNS cord-023095-4dannjjm 3272 14 compared compare VBN cord-023095-4dannjjm 3272 15 to to IN cord-023095-4dannjjm 3272 16 iliac iliac NN cord-023095-4dannjjm 3272 17 samples sample NNS cord-023095-4dannjjm 3272 18 from from IN cord-023095-4dannjjm 3272 19 2 2 CD cord-023095-4dannjjm 3272 20 cats cat NNS cord-023095-4dannjjm 3272 21 , , , cord-023095-4dannjjm 3272 22 and and CC cord-023095-4dannjjm 3272 23 overestimated overestimate VBN cord-023095-4dannjjm 3272 24 in in IN cord-023095-4dannjjm 3272 25 the the DT cord-023095-4dannjjm 3272 26 sternal sternal JJ cord-023095-4dannjjm 3272 27 sample sample NN cord-023095-4dannjjm 3272 28 from from IN cord-023095-4dannjjm 3272 29 1 1 CD cord-023095-4dannjjm 3272 30 cat cat NN cord-023095-4dannjjm 3272 31 . . . cord-023095-4dannjjm 3273 1 Bone bone NN cord-023095-4dannjjm 3273 2 marrow marrow NN cord-023095-4dannjjm 3273 3 cell cell NN cord-023095-4dannjjm 3273 4 morphology morphology NN cord-023095-4dannjjm 3273 5 was be VBD cord-023095-4dannjjm 3273 6 normal normal JJ cord-023095-4dannjjm 3273 7 in in IN cord-023095-4dannjjm 3273 8 all all DT cord-023095-4dannjjm 3273 9 acceptable acceptable JJ cord-023095-4dannjjm 3273 10 samples sample NNS cord-023095-4dannjjm 3273 11 . . . cord-023095-4dannjjm 3274 1 It -PRON- PRP cord-023095-4dannjjm 3274 2 was be VBD cord-023095-4dannjjm 3274 3 concluded conclude VBN cord-023095-4dannjjm 3274 4 that that IN cord-023095-4dannjjm 3274 5 sternal sternal JJ cord-023095-4dannjjm 3274 6 aspiration aspiration NN cord-023095-4dannjjm 3274 7 of of IN cord-023095-4dannjjm 3274 8 bone bone NN cord-023095-4dannjjm 3274 9 marrow marrow NN cord-023095-4dannjjm 3274 10 using use VBG cord-023095-4dannjjm 3274 11 a a DT cord-023095-4dannjjm 3274 12 22 22 CD cord-023095-4dannjjm 3274 13 - - SYM cord-023095-4dannjjm 3274 14 23 23 CD cord-023095-4dannjjm 3274 15 ga ga NNP cord-023095-4dannjjm 3274 16 hypodermic hypodermic NNP cord-023095-4dannjjm 3274 17 needle needle NN cord-023095-4dannjjm 3274 18 is be VBZ cord-023095-4dannjjm 3274 19 1 1 CD cord-023095-4dannjjm 3274 20 ) ) -RRB- cord-023095-4dannjjm 3274 21 easier easy JJR cord-023095-4dannjjm 3274 22 to to TO cord-023095-4dannjjm 3274 23 perform perform VB cord-023095-4dannjjm 3274 24 than than IN cord-023095-4dannjjm 3274 25 iliac iliac JJ cord-023095-4dannjjm 3274 26 aspiration aspiration NN cord-023095-4dannjjm 3274 27 ; ; : cord-023095-4dannjjm 3274 28 2 2 LS cord-023095-4dannjjm 3274 29 ) ) -RRB- cord-023095-4dannjjm 3274 30 safe safe JJ cord-023095-4dannjjm 3274 31 ; ; : cord-023095-4dannjjm 3274 32 but but CC cord-023095-4dannjjm 3274 33 3 3 LS cord-023095-4dannjjm 3274 34 ) ) -RRB- cord-023095-4dannjjm 3274 35 provides provide VBZ cord-023095-4dannjjm 3274 36 samples sample NNS cord-023095-4dannjjm 3274 37 of of IN cord-023095-4dannjjm 3274 38 lower low JJR cord-023095-4dannjjm 3274 39 quality quality NN cord-023095-4dannjjm 3274 40 than than IN cord-023095-4dannjjm 3274 41 iliac iliac JJ cord-023095-4dannjjm 3274 42 aspiration aspiration NN cord-023095-4dannjjm 3274 43 in in IN cord-023095-4dannjjm 3274 44 cats cat NNS cord-023095-4dannjjm 3274 45 . . . cord-023095-4dannjjm 3275 1 The the DT cord-023095-4dannjjm 3275 2 diameter diameter NN cord-023095-4dannjjm 3275 3 of of IN cord-023095-4dannjjm 3275 4 11 11 CD cord-023095-4dannjjm 3275 5 - - HYPH cord-023095-4dannjjm 3275 6 13ga 13ga NN cord-023095-4dannjjm 3275 7 Jamshidi Jamshidi NNP cord-023095-4dannjjm 3275 8 - - HYPH cord-023095-4dannjjm 3275 9 type type NN cord-023095-4dannjjm 3275 10 needles needle NNS cord-023095-4dannjjm 3275 11 makes make VBZ cord-023095-4dannjjm 3275 12 bone bone NN cord-023095-4dannjjm 3275 13 marrow marrow NN cord-023095-4dannjjm 3275 14 core core NN cord-023095-4dannjjm 3275 15 biopsy biopsy NN cord-023095-4dannjjm 3275 16 difficult difficult JJ cord-023095-4dannjjm 3275 17 in in IN cord-023095-4dannjjm 3275 18 cats cat NNS cord-023095-4dannjjm 3275 19 . . . cord-023095-4dannjjm 3276 1 In in IN cord-023095-4dannjjm 3276 2 this this DT cord-023095-4dannjjm 3276 3 study study NN cord-023095-4dannjjm 3276 4 , , , cord-023095-4dannjjm 3276 5 biopsies biopsy NNS cord-023095-4dannjjm 3276 6 of of IN cord-023095-4dannjjm 3276 7 the the DT cord-023095-4dannjjm 3276 8 left left JJ cord-023095-4dannjjm 3276 9 humeral humeral JJ cord-023095-4dannjjm 3276 10 head head NN cord-023095-4dannjjm 3276 11 were be VBD cord-023095-4dannjjm 3276 12 taken take VBN cord-023095-4dannjjm 3276 13 under under IN cord-023095-4dannjjm 3276 14 anesthesia anesthesia NN cord-023095-4dannjjm 3276 15 using use VBG cord-023095-4dannjjm 3276 16 a a DT cord-023095-4dannjjm 3276 17 1-inch 1-inch CD cord-023095-4dannjjm 3276 18 , , , cord-023095-4dannjjm 3276 19 15ga 15ga JJ cord-023095-4dannjjm 3276 20 needle needle NN cord-023095-4dannjjm 3276 21 ( ( -LRB- cord-023095-4dannjjm 3276 22 EZ EZ NNP cord-023095-4dannjjm 3276 23 - - HYPH cord-023095-4dannjjm 3276 24 IO IO NNP cord-023095-4dannjjm 3276 25 s s POS cord-023095-4dannjjm 3276 26 Intraosseous Intraosseous NNP cord-023095-4dannjjm 3276 27 Infusion Infusion NNP cord-023095-4dannjjm 3276 28 System System NNP cord-023095-4dannjjm 3276 29 , , , cord-023095-4dannjjm 3276 30 Vidacare Vidacare NNP cord-023095-4dannjjm 3276 31 ) ) -RRB- cord-023095-4dannjjm 3276 32 from from IN cord-023095-4dannjjm 3276 33 10 10 CD cord-023095-4dannjjm 3276 34 healthy healthy JJ cord-023095-4dannjjm 3276 35 cats cat NNS cord-023095-4dannjjm 3276 36 weighing weigh VBG cord-023095-4dannjjm 3276 37 3.4 3.4 CD cord-023095-4dannjjm 3276 38 - - SYM cord-023095-4dannjjm 3276 39 8.4 8.4 CD cord-023095-4dannjjm 3276 40 kg kg NNS cord-023095-4dannjjm 3276 41 with with IN cord-023095-4dannjjm 3276 42 body body NN cord-023095-4dannjjm 3276 43 condition condition NN cord-023095-4dannjjm 3276 44 scores score NNS cord-023095-4dannjjm 3276 45 of of IN cord-023095-4dannjjm 3276 46 5 5 CD cord-023095-4dannjjm 3276 47 - - SYM cord-023095-4dannjjm 3276 48 9 9 CD cord-023095-4dannjjm 3276 49 ( ( -LRB- cord-023095-4dannjjm 3276 50 on on IN cord-023095-4dannjjm 3276 51 a a DT cord-023095-4dannjjm 3276 52 scale scale NN cord-023095-4dannjjm 3276 53 of of IN cord-023095-4dannjjm 3276 54 1 1 CD cord-023095-4dannjjm 3276 55 - - SYM cord-023095-4dannjjm 3276 56 9 9 CD cord-023095-4dannjjm 3276 57 ) ) -RRB- cord-023095-4dannjjm 3276 58 . . . cord-023095-4dannjjm 3277 1 Humeral Humeral NNP cord-023095-4dannjjm 3277 2 biopsies biopsy NNS cord-023095-4dannjjm 3277 3 were be VBD cord-023095-4dannjjm 3277 4 compared compare VBN cord-023095-4dannjjm 3277 5 to to IN cord-023095-4dannjjm 3277 6 biopsies biopsy NNS cord-023095-4dannjjm 3277 7 taken take VBN cord-023095-4dannjjm 3277 8 from from IN cord-023095-4dannjjm 3277 9 the the DT cord-023095-4dannjjm 3277 10 left left JJ cord-023095-4dannjjm 3277 11 iliac iliac NNP cord-023095-4dannjjm 3277 12 crest crest NN cord-023095-4dannjjm 3277 13 using use VBG cord-023095-4dannjjm 3277 14 a a DT cord-023095-4dannjjm 3277 15 2-inch 2-inch CD cord-023095-4dannjjm 3277 16 , , , cord-023095-4dannjjm 3277 17 13ga 13ga NN cord-023095-4dannjjm 3277 18 Jamshidi Jamshidi NNP cord-023095-4dannjjm 3277 19 needle needle NN cord-023095-4dannjjm 3277 20 . . . cord-023095-4dannjjm 3278 1 Biopsies biopsy NNS cord-023095-4dannjjm 3278 2 were be VBD cord-023095-4dannjjm 3278 3 performed perform VBN cord-023095-4dannjjm 3278 4 in in IN cord-023095-4dannjjm 3278 5 randomized randomized JJ cord-023095-4dannjjm 3278 6 order order NN cord-023095-4dannjjm 3278 7 by by IN cord-023095-4dannjjm 3278 8 one one CD cord-023095-4dannjjm 3278 9 investigator investigator NN cord-023095-4dannjjm 3278 10 . . . cord-023095-4dannjjm 3279 1 Biopsy Biopsy NNP cord-023095-4dannjjm 3279 2 was be VBD cord-023095-4dannjjm 3279 3 repeated repeat VBN cord-023095-4dannjjm 3279 4 to to IN cord-023095-4dannjjm 3279 5 a a DT cord-023095-4dannjjm 3279 6 maximum maximum NN cord-023095-4dannjjm 3279 7 of of IN cord-023095-4dannjjm 3279 8 3 3 CD cord-023095-4dannjjm 3279 9 attempts attempt NNS cord-023095-4dannjjm 3279 10 until until IN cord-023095-4dannjjm 3279 11 a a DT cord-023095-4dannjjm 3279 12 specimen specimen NN cord-023095-4dannjjm 3279 13 ! ! . cord-023095-4dannjjm 3280 1 5 5 CD cord-023095-4dannjjm 3280 2 mm mm NNP cord-023095-4dannjjm 3280 3 long long RB cord-023095-4dannjjm 3280 4 was be VBD cord-023095-4dannjjm 3280 5 obtained obtain VBN cord-023095-4dannjjm 3280 6 . . . cord-023095-4dannjjm 3281 1 Difficulty difficulty NN cord-023095-4dannjjm 3281 2 of of IN cord-023095-4dannjjm 3281 3 site site NN cord-023095-4dannjjm 3281 4 localization localization NN cord-023095-4dannjjm 3281 5 , , , cord-023095-4dannjjm 3281 6 needle needle NN cord-023095-4dannjjm 3281 7 insertion insertion NN cord-023095-4dannjjm 3281 8 and and CC cord-023095-4dannjjm 3281 9 needle needle NN cord-023095-4dannjjm 3281 10 advancement advancement NN cord-023095-4dannjjm 3281 11 were be VBD cord-023095-4dannjjm 3281 12 scored score VBN cord-023095-4dannjjm 3281 13 from from IN cord-023095-4dannjjm 3281 14 1 1 CD cord-023095-4dannjjm 3281 15 ( ( -LRB- cord-023095-4dannjjm 3281 16 easiest easy JJS cord-023095-4dannjjm 3281 17 ) ) -RRB- cord-023095-4dannjjm 3281 18 to to IN cord-023095-4dannjjm 3281 19 5 5 CD cord-023095-4dannjjm 3281 20 ( ( -LRB- cord-023095-4dannjjm 3281 21 hardest hard RBS cord-023095-4dannjjm 3281 22 ) ) -RRB- cord-023095-4dannjjm 3281 23 . . . cord-023095-4dannjjm 3282 1 Specimens specimen NNS cord-023095-4dannjjm 3282 2 were be VBD cord-023095-4dannjjm 3282 3 wrapped wrap VBN cord-023095-4dannjjm 3282 4 in in IN cord-023095-4dannjjm 3282 5 tissue tissue NN cord-023095-4dannjjm 3282 6 paper paper NN cord-023095-4dannjjm 3282 7 and and CC cord-023095-4dannjjm 3282 8 placed place VBN cord-023095-4dannjjm 3282 9 in in IN cord-023095-4dannjjm 3282 10 Davidson Davidson NNP cord-023095-4dannjjm 3282 11 's 's POS cord-023095-4dannjjm 3282 12 fixative fixative NN cord-023095-4dannjjm 3282 13 for for IN cord-023095-4dannjjm 3282 14 15 15 CD cord-023095-4dannjjm 3282 15 min min NN cord-023095-4dannjjm 3282 16 and and CC cord-023095-4dannjjm 3282 17 then then RB cord-023095-4dannjjm 3282 18 transferred transfer VBD cord-023095-4dannjjm 3282 19 to to IN cord-023095-4dannjjm 3282 20 formalin formalin NN cord-023095-4dannjjm 3282 21 . . . cord-023095-4dannjjm 3283 1 Biopsy biopsy NN cord-023095-4dannjjm 3283 2 sections section NNS cord-023095-4dannjjm 3283 3 were be VBD cord-023095-4dannjjm 3283 4 reviewed review VBN cord-023095-4dannjjm 3283 5 by by IN cord-023095-4dannjjm 3283 6 a a DT cord-023095-4dannjjm 3283 7 pathologist pathologist NN cord-023095-4dannjjm 3283 8 blinded blind VBN cord-023095-4dannjjm 3283 9 to to IN cord-023095-4dannjjm 3283 10 biopsy biopsy NN cord-023095-4dannjjm 3283 11 site site NN cord-023095-4dannjjm 3283 12 and and CC cord-023095-4dannjjm 3283 13 cat cat NN cord-023095-4dannjjm 3283 14 . . . cord-023095-4dannjjm 3284 1 Biopsy biopsy JJ cord-023095-4dannjjm 3284 2 length length NN cord-023095-4dannjjm 3284 3 on on IN cord-023095-4dannjjm 3284 4 the the DT cord-023095-4dannjjm 3284 5 slide slide NN cord-023095-4dannjjm 3284 6 was be VBD cord-023095-4dannjjm 3284 7 measured measure VBN cord-023095-4dannjjm 3284 8 , , , cord-023095-4dannjjm 3284 9 and and CC cord-023095-4dannjjm 3284 10 biopsy biopsy NN cord-023095-4dannjjm 3284 11 quality quality NN cord-023095-4dannjjm 3284 12 was be VBD cord-023095-4dannjjm 3284 13 scored score VBN cord-023095-4dannjjm 3284 14 from from IN cord-023095-4dannjjm 3284 15 0 0 NFP cord-023095-4dannjjm 3284 16 ( ( -LRB- cord-023095-4dannjjm 3284 17 no no DT cord-023095-4dannjjm 3284 18 hematopoietic hematopoietic JJ cord-023095-4dannjjm 3284 19 tissue tissue NN cord-023095-4dannjjm 3284 20 ) ) -RRB- cord-023095-4dannjjm 3284 21 to to IN cord-023095-4dannjjm 3284 22 5 5 CD cord-023095-4dannjjm 3284 23 ( ( -LRB- cord-023095-4dannjjm 3284 24 ! ! . cord-023095-4dannjjm 3284 25 5 5 CD cord-023095-4dannjjm 3284 26 intertrabecular intertrabecular JJ cord-023095-4dannjjm 3284 27 spaces space NNS cord-023095-4dannjjm 3284 28 free free JJ cord-023095-4dannjjm 3284 29 of of IN cord-023095-4dannjjm 3284 30 artifact artifact NN cord-023095-4dannjjm 3284 31 ) ) -RRB- cord-023095-4dannjjm 3284 32 . . . cord-023095-4dannjjm 3285 1 Post post NN cord-023095-4dannjjm 3285 2 - - NN cord-023095-4dannjjm 3285 3 procedure procedure NN cord-023095-4dannjjm 3285 4 , , , cord-023095-4dannjjm 3285 5 cats cat NNS cord-023095-4dannjjm 3285 6 were be VBD cord-023095-4dannjjm 3285 7 treated treat VBN cord-023095-4dannjjm 3285 8 with with IN cord-023095-4dannjjm 3285 9 tramadol tramadol NN cord-023095-4dannjjm 3285 10 ( ( -LRB- cord-023095-4dannjjm 3285 11 4 4 CD cord-023095-4dannjjm 3285 12 - - SYM cord-023095-4dannjjm 3285 13 5 5 CD cord-023095-4dannjjm 3285 14 mg mg NNP cord-023095-4dannjjm 3285 15 / / SYM cord-023095-4dannjjm 3285 16 kg kg NNP cord-023095-4dannjjm 3285 17 , , , cord-023095-4dannjjm 3285 18 PO PO NNP cord-023095-4dannjjm 3285 19 , , , cord-023095-4dannjjm 3285 20 q12h q12h CD cord-023095-4dannjjm 3285 21 ) ) -RRB- cord-023095-4dannjjm 3285 22 for for IN cord-023095-4dannjjm 3285 23 3 3 CD cord-023095-4dannjjm 3285 24 days day NNS cord-023095-4dannjjm 3285 25 , , , cord-023095-4dannjjm 3285 26 and and CC cord-023095-4dannjjm 3285 27 assessed assess VBN cord-023095-4dannjjm 3285 28 for for IN cord-023095-4dannjjm 3285 29 postbiopsy postbiopsy JJ cord-023095-4dannjjm 3285 30 pain pain NN cord-023095-4dannjjm 3285 31 ( ( -LRB- cord-023095-4dannjjm 3285 32 Colorado Colorado NNP cord-023095-4dannjjm 3285 33 State State NNP cord-023095-4dannjjm 3285 34 University University NNP cord-023095-4dannjjm 3285 35 Feline Feline NNP cord-023095-4dannjjm 3285 36 Acute acute JJ cord-023095-4dannjjm 3285 37 Pain pain NN cord-023095-4dannjjm 3285 38 Scale scale NN cord-023095-4dannjjm 3285 39 , , , cord-023095-4dannjjm 3285 40 range range VBP cord-023095-4dannjjm 3285 41 0 0 NFP cord-023095-4dannjjm 3285 42 [ [ -LRB- cord-023095-4dannjjm 3285 43 no no DT cord-023095-4dannjjm 3285 44 pain pain NN cord-023095-4dannjjm 3285 45 ] ] -RRB- cord-023095-4dannjjm 3285 46 -4 -4 FW cord-023095-4dannjjm 3285 47 [ [ -LRB- cord-023095-4dannjjm 3285 48 maximum maximum NN cord-023095-4dannjjm 3285 49 ] ] -RRB- cord-023095-4dannjjm 3285 50 ) ) -RRB- cord-023095-4dannjjm 3285 51 and and CC cord-023095-4dannjjm 3285 52 swelling swelling NN cord-023095-4dannjjm 3285 53 of of IN cord-023095-4dannjjm 3285 54 biopsy biopsy NN cord-023095-4dannjjm 3285 55 sites site NNS cord-023095-4dannjjm 3285 56 ( ( -LRB- cord-023095-4dannjjm 3285 57 range range NN cord-023095-4dannjjm 3285 58 0 0 CD cord-023095-4dannjjm 3286 1 [ [ -LRB- cord-023095-4dannjjm 3286 2 none none NN cord-023095-4dannjjm 3286 3 ] ] -RRB- cord-023095-4dannjjm 3286 4 -3 -3 NNP cord-023095-4dannjjm 3287 1 [ [ -LRB- cord-023095-4dannjjm 3287 2 marked mark VBN cord-023095-4dannjjm 3287 3 ] ] -RRB- cord-023095-4dannjjm 3287 4 ) ) -RRB- cord-023095-4dannjjm 3287 5 . . . cord-023095-4dannjjm 3288 1 Data datum NNS cord-023095-4dannjjm 3288 2 were be VBD cord-023095-4dannjjm 3288 3 analyzed analyze VBN cord-023095-4dannjjm 3288 4 by by IN cord-023095-4dannjjm 3288 5 ANCOVA ANCOVA NNP cord-023095-4dannjjm 3288 6 accounting accounting NN cord-023095-4dannjjm 3288 7 for for IN cord-023095-4dannjjm 3288 8 effects effect NNS cord-023095-4dannjjm 3288 9 of of IN cord-023095-4dannjjm 3288 10 weight weight NN cord-023095-4dannjjm 3288 11 and and CC cord-023095-4dannjjm 3288 12 body body NN cord-023095-4dannjjm 3288 13 condition condition NN cord-023095-4dannjjm 3288 14 score score NN cord-023095-4dannjjm 3288 15 . . . cord-023095-4dannjjm 3289 1 There there EX cord-023095-4dannjjm 3289 2 were be VBD cord-023095-4dannjjm 3289 3 no no DT cord-023095-4dannjjm 3289 4 significant significant JJ cord-023095-4dannjjm 3289 5 differences difference NNS cord-023095-4dannjjm 3289 6 between between IN cord-023095-4dannjjm 3289 7 15ga 15ga NN cord-023095-4dannjjm 3289 8 and and CC cord-023095-4dannjjm 3289 9 13ga 13ga NN cord-023095-4dannjjm 3289 10 biopsies biopsy NNS cord-023095-4dannjjm 3289 11 except except IN cord-023095-4dannjjm 3289 12 for for IN cord-023095-4dannjjm 3289 13 post post JJ cord-023095-4dannjjm 3289 14 - - JJ cord-023095-4dannjjm 3289 15 biopsy biopsy JJ cord-023095-4dannjjm 3289 16 swelling swelling NN cord-023095-4dannjjm 3289 17 , , , cord-023095-4dannjjm 3289 18 and and CC cord-023095-4dannjjm 3289 19 there there EX cord-023095-4dannjjm 3289 20 were be VBD cord-023095-4dannjjm 3289 21 no no DT cord-023095-4dannjjm 3289 22 significant significant JJ cord-023095-4dannjjm 3289 23 effects effect NNS cord-023095-4dannjjm 3289 24 of of IN cord-023095-4dannjjm 3289 25 body body NN cord-023095-4dannjjm 3289 26 weight weight NN cord-023095-4dannjjm 3289 27 and and CC cord-023095-4dannjjm 3289 28 body body NN cord-023095-4dannjjm 3289 29 condition condition NN cord-023095-4dannjjm 3289 30 . . . cord-023095-4dannjjm 3290 1 Six six CD cord-023095-4dannjjm 3290 2 ( ( -LRB- cord-023095-4dannjjm 3290 3 60 60 CD cord-023095-4dannjjm 3290 4 % % NN cord-023095-4dannjjm 3290 5 ) ) -RRB- cord-023095-4dannjjm 3290 6 of of IN cord-023095-4dannjjm 3290 7 15 15 CD cord-023095-4dannjjm 3290 8 ga ga NNP cord-023095-4dannjjm 3290 9 and and CC cord-023095-4dannjjm 3290 10 5 5 CD cord-023095-4dannjjm 3290 11 ( ( -LRB- cord-023095-4dannjjm 3290 12 50 50 CD cord-023095-4dannjjm 3290 13 % % NN cord-023095-4dannjjm 3290 14 ) ) -RRB- cord-023095-4dannjjm 3290 15 of of IN cord-023095-4dannjjm 3290 16 13ga 13ga NN cord-023095-4dannjjm 3290 17 biopsies biopsy NNS cord-023095-4dannjjm 3290 18 were be VBD cord-023095-4dannjjm 3290 19 considered consider VBN cord-023095-4dannjjm 3290 20 acceptable acceptable JJ cord-023095-4dannjjm 3290 21 specimens specimen NNS cord-023095-4dannjjm 3290 22 for for IN cord-023095-4dannjjm 3290 23 assessment assessment NN cord-023095-4dannjjm 3290 24 of of IN cord-023095-4dannjjm 3290 25 bone bone NN cord-023095-4dannjjm 3290 26 marrow marrow NN cord-023095-4dannjjm 3290 27 architecture architecture NN cord-023095-4dannjjm 3290 28 and and CC cord-023095-4dannjjm 3290 29 morphology morphology NN cord-023095-4dannjjm 3290 30 ; ; : cord-023095-4dannjjm 3290 31 all all DT cord-023095-4dannjjm 3290 32 intact intact JJ cord-023095-4dannjjm 3290 33 spaces space NNS cord-023095-4dannjjm 3290 34 in in IN cord-023095-4dannjjm 3290 35 these these DT cord-023095-4dannjjm 3290 36 biopsies biopsy NNS cord-023095-4dannjjm 3290 37 had have VBD cord-023095-4dannjjm 3290 38 normal normal JJ cord-023095-4dannjjm 3290 39 hematopoiesis hematopoiesis NN cord-023095-4dannjjm 3290 40 and and CC cord-023095-4dannjjm 3290 41 cell cell NN cord-023095-4dannjjm 3290 42 morphology morphology NN cord-023095-4dannjjm 3290 43 . . . cord-023095-4dannjjm 3291 1 Comparison comparison NN cord-023095-4dannjjm 3291 2 of of IN cord-023095-4dannjjm 3291 3 acceptable acceptable JJ cord-023095-4dannjjm 3291 4 15 15 CD cord-023095-4dannjjm 3291 5 ga ga NNP cord-023095-4dannjjm 3291 6 to to IN cord-023095-4dannjjm 3291 7 13 13 CD cord-023095-4dannjjm 3291 8 ga ga NNP cord-023095-4dannjjm 3291 9 biopsy biopsy NN cord-023095-4dannjjm 3291 10 specimens specimen NNS cord-023095-4dannjjm 3291 11 from from IN cord-023095-4dannjjm 3291 12 4 4 CD cord-023095-4dannjjm 3291 13 cats cat NNS cord-023095-4dannjjm 3291 14 showed show VBD cord-023095-4dannjjm 3291 15 no no DT cord-023095-4dannjjm 3291 16 significant significant JJ cord-023095-4dannjjm 3291 17 differences difference NNS cord-023095-4dannjjm 3291 18 for for IN cord-023095-4dannjjm 3291 19 cell cell NN cord-023095-4dannjjm 3291 20 density density NN cord-023095-4dannjjm 3291 21 and and CC cord-023095-4dannjjm 3291 22 lymphocytes lymphocyte NNS cord-023095-4dannjjm 3291 23 / / SYM cord-023095-4dannjjm 3291 24 plasma plasma NN cord-023095-4dannjjm 3291 25 cells cell NNS cord-023095-4dannjjm 3291 26 , , , cord-023095-4dannjjm 3291 27 while while IN cord-023095-4dannjjm 3291 28 cellularity cellularity NN cord-023095-4dannjjm 3291 29 , , , cord-023095-4dannjjm 3291 30 assessed assess VBN cord-023095-4dannjjm 3291 31 as as RB cord-023095-4dannjjm 3291 32 high high JJ cord-023095-4dannjjm 3291 33 in in IN cord-023095-4dannjjm 3291 34 2 2 CD cord-023095-4dannjjm 3291 35 of of IN cord-023095-4dannjjm 3291 36 the the DT cord-023095-4dannjjm 3291 37 13 13 CD cord-023095-4dannjjm 3291 38 ga ga NNP cord-023095-4dannjjm 3291 39 biopsies biopsy NNS cord-023095-4dannjjm 3291 40 , , , cord-023095-4dannjjm 3291 41 was be VBD cord-023095-4dannjjm 3291 42 assessed assess VBN cord-023095-4dannjjm 3291 43 as as IN cord-023095-4dannjjm 3291 44 medium medium NN cord-023095-4dannjjm 3291 45 in in IN cord-023095-4dannjjm 3291 46 corresponding correspond VBG cord-023095-4dannjjm 3291 47 15ga 15ga JJ cord-023095-4dannjjm 3291 48 biopsies biopsy NNS cord-023095-4dannjjm 3291 49 ; ; : cord-023095-4dannjjm 3291 50 and and CC cord-023095-4dannjjm 3291 51 megakaryocytes megakaryocytes NNP cord-023095-4dannjjm 3291 52 , , , cord-023095-4dannjjm 3291 53 assessed assess VBN cord-023095-4dannjjm 3291 54 as as IN cord-023095-4dannjjm 3291 55 4 4 CD cord-023095-4dannjjm 3291 56 - - SYM cord-023095-4dannjjm 3291 57 9 9 CD cord-023095-4dannjjm 3291 58 / / SYM cord-023095-4dannjjm 3291 59 low low JJ cord-023095-4dannjjm 3291 60 - - HYPH cord-023095-4dannjjm 3291 61 power power NN cord-023095-4dannjjm 3291 62 field field NN cord-023095-4dannjjm 3291 63 in in IN cord-023095-4dannjjm 3291 64 one one CD cord-023095-4dannjjm 3291 65 13ga 13ga NN cord-023095-4dannjjm 3291 66 biopsy biopsy NN cord-023095-4dannjjm 3291 67 , , , cord-023095-4dannjjm 3291 68 were be VBD cord-023095-4dannjjm 3291 69 assessed assess VBN cord-023095-4dannjjm 3291 70 as as IN cord-023095-4dannjjm 3291 71 3 3 CD cord-023095-4dannjjm 3291 72 / / SYM cord-023095-4dannjjm 3291 73 low low JJ cord-023095-4dannjjm 3291 74 - - HYPH cord-023095-4dannjjm 3291 75 power power NN cord-023095-4dannjjm 3291 76 field field NN cord-023095-4dannjjm 3291 77 in in IN cord-023095-4dannjjm 3291 78 the the DT cord-023095-4dannjjm 3291 79 15 15 CD cord-023095-4dannjjm 3291 80 ga ga NNP cord-023095-4dannjjm 3291 81 biopsy biopsy NNP cord-023095-4dannjjm 3291 82 . . . cord-023095-4dannjjm 3292 1 Myeloid myeloid NN cord-023095-4dannjjm 3292 2 : : : cord-023095-4dannjjm 3292 3 erythroid erythroid NN cord-023095-4dannjjm 3292 4 ratios ratio NNS cord-023095-4dannjjm 3292 5 were be VBD cord-023095-4dannjjm 3292 6 greater great JJR cord-023095-4dannjjm 3292 7 in in IN cord-023095-4dannjjm 3292 8 15 15 CD cord-023095-4dannjjm 3292 9 ga ga NNP cord-023095-4dannjjm 3292 10 biopsies biopsy NNS cord-023095-4dannjjm 3292 11 compared compare VBN cord-023095-4dannjjm 3292 12 to to IN cord-023095-4dannjjm 3292 13 13 13 CD cord-023095-4dannjjm 3292 14 ga ga NNP cord-023095-4dannjjm 3292 15 biopsies biopsy NNS cord-023095-4dannjjm 3292 16 in in IN cord-023095-4dannjjm 3292 17 2 2 CD cord-023095-4dannjjm 3292 18 cats cat NNS cord-023095-4dannjjm 3292 19 , , , cord-023095-4dannjjm 3292 20 and and CC cord-023095-4dannjjm 3292 21 less less JJR cord-023095-4dannjjm 3292 22 in in IN cord-023095-4dannjjm 3292 23 the the DT cord-023095-4dannjjm 3292 24 15 15 CD cord-023095-4dannjjm 3292 25 ga ga NNP cord-023095-4dannjjm 3292 26 biopsy biopsy NNP cord-023095-4dannjjm 3292 27 in in IN cord-023095-4dannjjm 3292 28 one one CD cord-023095-4dannjjm 3292 29 cat cat NN cord-023095-4dannjjm 3292 30 . . . cord-023095-4dannjjm 3293 1 Discordant discordant JJ cord-023095-4dannjjm 3293 2 results result NNS cord-023095-4dannjjm 3293 3 between between IN cord-023095-4dannjjm 3293 4 biopsies biopsy NNS cord-023095-4dannjjm 3293 5 were be VBD cord-023095-4dannjjm 3293 6 not not RB cord-023095-4dannjjm 3293 7 related relate VBN cord-023095-4dannjjm 3293 8 to to IN cord-023095-4dannjjm 3293 9 differences difference NNS cord-023095-4dannjjm 3293 10 in in IN cord-023095-4dannjjm 3293 11 quality quality NN cord-023095-4dannjjm 3293 12 . . . cord-023095-4dannjjm 3294 1 In in IN cord-023095-4dannjjm 3294 2 conclusion conclusion NN cord-023095-4dannjjm 3294 3 , , , cord-023095-4dannjjm 3294 4 15 15 CD cord-023095-4dannjjm 3294 5 ga ga NNP cord-023095-4dannjjm 3294 6 bone bone NN cord-023095-4dannjjm 3294 7 marrow marrow NN cord-023095-4dannjjm 3294 8 biopsy biopsy NN cord-023095-4dannjjm 3294 9 of of IN cord-023095-4dannjjm 3294 10 the the DT cord-023095-4dannjjm 3294 11 humerus humerus NN cord-023095-4dannjjm 3294 12 was be VBD cord-023095-4dannjjm 3294 13 as as RB cord-023095-4dannjjm 3294 14 likely likely JJ cord-023095-4dannjjm 3294 15 to to TO cord-023095-4dannjjm 3294 16 yield yield VB cord-023095-4dannjjm 3294 17 a a DT cord-023095-4dannjjm 3294 18 specimen specimen NN cord-023095-4dannjjm 3294 19 of of IN cord-023095-4dannjjm 3294 20 acceptable acceptable JJ cord-023095-4dannjjm 3294 21 quality quality NN cord-023095-4dannjjm 3294 22 as as IN cord-023095-4dannjjm 3294 23 was be VBD cord-023095-4dannjjm 3294 24 13 13 CD cord-023095-4dannjjm 3294 25 ga ga NNP cord-023095-4dannjjm 3294 26 biopsy biopsy NNP cord-023095-4dannjjm 3294 27 of of IN cord-023095-4dannjjm 3294 28 the the DT cord-023095-4dannjjm 3294 29 ilium ilium NNP cord-023095-4dannjjm 3294 30 , , , cord-023095-4dannjjm 3294 31 and and CC cord-023095-4dannjjm 3294 32 resulted result VBD cord-023095-4dannjjm 3294 33 in in IN cord-023095-4dannjjm 3294 34 less less JJR cord-023095-4dannjjm 3294 35 post post JJ cord-023095-4dannjjm 3294 36 - - JJ cord-023095-4dannjjm 3294 37 biopsy biopsy JJ cord-023095-4dannjjm 3294 38 swelling swelling NN cord-023095-4dannjjm 3294 39 . . . cord-023095-4dannjjm 3295 1 Reports report NNS cord-023095-4dannjjm 3295 2 on on IN cord-023095-4dannjjm 3295 3 canine canine JJ cord-023095-4dannjjm 3295 4 acute acute JJ cord-023095-4dannjjm 3295 5 liver liver NN cord-023095-4dannjjm 3295 6 failure failure NN cord-023095-4dannjjm 3295 7 ( ( -LRB- cord-023095-4dannjjm 3295 8 ALF ALF NNP cord-023095-4dannjjm 3295 9 ) ) -RRB- cord-023095-4dannjjm 3295 10 include include VBP cord-023095-4dannjjm 3295 11 individual individual JJ cord-023095-4dannjjm 3295 12 or or CC cord-023095-4dannjjm 3295 13 small small JJ cord-023095-4dannjjm 3295 14 case case NN cord-023095-4dannjjm 3295 15 series series NN cord-023095-4dannjjm 3295 16 of of IN cord-023095-4dannjjm 3295 17 animals animal NNS cord-023095-4dannjjm 3295 18 with with IN cord-023095-4dannjjm 3295 19 a a DT cord-023095-4dannjjm 3295 20 specific specific JJ cord-023095-4dannjjm 3295 21 diagnosis diagnosis NN cord-023095-4dannjjm 3295 22 . . . cord-023095-4dannjjm 3296 1 The the DT cord-023095-4dannjjm 3296 2 aim aim NN cord-023095-4dannjjm 3296 3 of of IN cord-023095-4dannjjm 3296 4 this this DT cord-023095-4dannjjm 3296 5 study study NN cord-023095-4dannjjm 3296 6 was be VBD cord-023095-4dannjjm 3296 7 to to TO cord-023095-4dannjjm 3296 8 describe describe VB cord-023095-4dannjjm 3296 9 the the DT cord-023095-4dannjjm 3296 10 clinical clinical JJ cord-023095-4dannjjm 3296 11 course course NN cord-023095-4dannjjm 3296 12 , , , cord-023095-4dannjjm 3296 13 outcome outcome NN cord-023095-4dannjjm 3296 14 and and CC cord-023095-4dannjjm 3296 15 etiology etiology NN cord-023095-4dannjjm 3296 16 of of IN cord-023095-4dannjjm 3296 17 ALF ALF NNP cord-023095-4dannjjm 3296 18 in in IN cord-023095-4dannjjm 3296 19 dogs dog NNS cord-023095-4dannjjm 3296 20 presenting present VBG cord-023095-4dannjjm 3296 21 to to IN cord-023095-4dannjjm 3296 22 a a DT cord-023095-4dannjjm 3296 23 referral referral JJ cord-023095-4dannjjm 3296 24 hospital hospital NN cord-023095-4dannjjm 3296 25 . . . cord-023095-4dannjjm 3297 1 Medical medical JJ cord-023095-4dannjjm 3297 2 records record NNS cord-023095-4dannjjm 3297 3 ( ( -LRB- cord-023095-4dannjjm 3297 4 1995 1995 CD cord-023095-4dannjjm 3297 5 ) ) -RRB- cord-023095-4dannjjm 3297 6 ( ( -LRB- cord-023095-4dannjjm 3297 7 1996 1996 CD cord-023095-4dannjjm 3297 8 ) ) -RRB- cord-023095-4dannjjm 3297 9 ( ( -LRB- cord-023095-4dannjjm 3297 10 1997 1997 CD cord-023095-4dannjjm 3297 11 ) ) -RRB- cord-023095-4dannjjm 3297 12 ( ( -LRB- cord-023095-4dannjjm 3297 13 1998 1998 CD cord-023095-4dannjjm 3297 14 ) ) -RRB- cord-023095-4dannjjm 3297 15 ( ( -LRB- cord-023095-4dannjjm 3297 16 1999 1999 CD cord-023095-4dannjjm 3297 17 ) ) -RRB- cord-023095-4dannjjm 3297 18 ( ( -LRB- cord-023095-4dannjjm 3297 19 2000 2000 CD cord-023095-4dannjjm 3297 20 ) ) -RRB- cord-023095-4dannjjm 3297 21 ( ( -LRB- cord-023095-4dannjjm 3297 22 2001 2001 CD cord-023095-4dannjjm 3297 23 ) ) -RRB- cord-023095-4dannjjm 3297 24 ( ( -LRB- cord-023095-4dannjjm 3297 25 2002 2002 CD cord-023095-4dannjjm 3297 26 ) ) -RRB- cord-023095-4dannjjm 3297 27 ( ( -LRB- cord-023095-4dannjjm 3297 28 2003 2003 CD cord-023095-4dannjjm 3297 29 ) ) -RRB- cord-023095-4dannjjm 3297 30 ( ( -LRB- cord-023095-4dannjjm 3297 31 2004 2004 CD cord-023095-4dannjjm 3297 32 ) ) -RRB- cord-023095-4dannjjm 3297 33 ( ( -LRB- cord-023095-4dannjjm 3297 34 2005 2005 CD cord-023095-4dannjjm 3297 35 ) ) -RRB- cord-023095-4dannjjm 3297 36 ( ( -LRB- cord-023095-4dannjjm 3297 37 2006 2006 CD cord-023095-4dannjjm 3297 38 ) ) -RRB- cord-023095-4dannjjm 3297 39 ( ( -LRB- cord-023095-4dannjjm 3297 40 2007 2007 CD cord-023095-4dannjjm 3297 41 ) ) -RRB- cord-023095-4dannjjm 3297 42 ( ( -LRB- cord-023095-4dannjjm 3297 43 2008 2008 CD cord-023095-4dannjjm 3297 44 ) ) -RRB- cord-023095-4dannjjm 3297 45 ( ( -LRB- cord-023095-4dannjjm 3297 46 2009 2009 CD cord-023095-4dannjjm 3297 47 ) ) -RRB- cord-023095-4dannjjm 3297 48 ( ( -LRB- cord-023095-4dannjjm 3297 49 2010 2010 CD cord-023095-4dannjjm 3297 50 ) ) -RRB- cord-023095-4dannjjm 3297 51 were be VBD cord-023095-4dannjjm 3297 52 reviewed review VBN cord-023095-4dannjjm 3297 53 for for IN cord-023095-4dannjjm 3297 54 a a DT cord-023095-4dannjjm 3297 55 diagnosis diagnosis NN cord-023095-4dannjjm 3297 56 of of IN cord-023095-4dannjjm 3297 57 ALF ALF NNP cord-023095-4dannjjm 3297 58 ( ( -LRB- cord-023095-4dannjjm 3297 59 elevated elevated JJ cord-023095-4dannjjm 3297 60 serum serum NN cord-023095-4dannjjm 3297 61 bilirubin bilirubin NN cord-023095-4dannjjm 3297 62 or or CC cord-023095-4dannjjm 3297 63 icterus icterus NN cord-023095-4dannjjm 3297 64 with with IN cord-023095-4dannjjm 3297 65 concurrent concurrent JJ cord-023095-4dannjjm 3297 66 coagulopathy coagulopathy NN cord-023095-4dannjjm 3297 67 or or CC cord-023095-4dannjjm 3297 68 hepatic hepatic JJ cord-023095-4dannjjm 3297 69 encephalopathy encephalopathy NN cord-023095-4dannjjm 3297 70 ( ( -LRB- cord-023095-4dannjjm 3297 71 HE he NN cord-023095-4dannjjm 3297 72 ) ) -RRB- cord-023095-4dannjjm 3297 73 ) ) -RRB- cord-023095-4dannjjm 3297 74 . . . cord-023095-4dannjjm 3298 1 Fifty fifty CD cord-023095-4dannjjm 3298 2 cases case NNS cord-023095-4dannjjm 3298 3 were be VBD cord-023095-4dannjjm 3298 4 identified identify VBN cord-023095-4dannjjm 3298 5 representing represent VBG cord-023095-4dannjjm 3298 6 22 22 CD cord-023095-4dannjjm 3298 7 breeds breed NNS cord-023095-4dannjjm 3298 8 : : : cord-023095-4dannjjm 3298 9 7 7 CD cord-023095-4dannjjm 3298 10 Labradors Labradors NNP cord-023095-4dannjjm 3298 11 retrievers retriever NNS cord-023095-4dannjjm 3298 12 , , , cord-023095-4dannjjm 3298 13 6 6 CD cord-023095-4dannjjm 3298 14 Golden golden JJ cord-023095-4dannjjm 3298 15 retrievers retriever NNS cord-023095-4dannjjm 3298 16 , , , cord-023095-4dannjjm 3298 17 3 3 CD cord-023095-4dannjjm 3298 18 German german JJ cord-023095-4dannjjm 3298 19 shepherds shepherd NNS cord-023095-4dannjjm 3298 20 , , , cord-023095-4dannjjm 3298 21 and and CC cord-023095-4dannjjm 3298 22 3 3 CD cord-023095-4dannjjm 3298 23 Cocker Cocker NNP cord-023095-4dannjjm 3298 24 spaniels spaniel NNS cord-023095-4dannjjm 3298 25 . . . cord-023095-4dannjjm 3299 1 Median median JJ cord-023095-4dannjjm 3299 2 age age NN cord-023095-4dannjjm 3299 3 was be VBD cord-023095-4dannjjm 3299 4 6 6 CD cord-023095-4dannjjm 3299 5 years year NNS cord-023095-4dannjjm 3299 6 ( ( -LRB- cord-023095-4dannjjm 3299 7 1 1 CD cord-023095-4dannjjm 3299 8 m m NN cord-023095-4dannjjm 3299 9 to to IN cord-023095-4dannjjm 3299 10 Humerus Humerus NNP cord-023095-4dannjjm 3299 11 , , , cord-023095-4dannjjm 3299 12 15 15 CD cord-023095-4dannjjm 3299 13 ga ga NNP cord-023095-4dannjjm 3299 14 5.1 5.1 CD cord-023095-4dannjjm 3299 15 AE AE NNP cord-023095-4dannjjm 3299 16 0.9 0.9 CD cord-023095-4dannjjm 3299 17 5.6 5.6 CD cord-023095-4dannjjm 3299 18 AE AE NNP cord-023095-4dannjjm 3299 19 0.6 0.6 CD cord-023095-4dannjjm 3299 20 2.1 2.1 CD cord-023095-4dannjjm 3299 21 AE AE NNP cord-023095-4dannjjm 3299 22 0.5 0.5 CD cord-023095-4dannjjm 3300 1 6.0 6.0 CD cord-023095-4dannjjm 3300 2 AE AE NNP cord-023095-4dannjjm 3300 3 0.7 0.7 CD cord-023095-4dannjjm 3300 4 0 0 SYM cord-023095-4dannjjm 3300 5 0 0 NFP cord-023095-4dannjjm 3300 6 Ã ã NN cord-023095-4dannjjm 3300 7 ( ( -LRB- cord-023095-4dannjjm 3300 8 2.2 2.2 CD cord-023095-4dannjjm 3300 9 - - SYM cord-023095-4dannjjm 3300 10 9.3 9.3 CD cord-023095-4dannjjm 3300 11 ) ) -RRB- cord-023095-4dannjjm 3300 12 ( ( -LRB- cord-023095-4dannjjm 3300 13 3 3 CD cord-023095-4dannjjm 3300 14 - - SYM cord-023095-4dannjjm 3300 15 9 9 CD cord-023095-4dannjjm 3300 16 ) ) -RRB- cord-023095-4dannjjm 3300 17 ( ( -LRB- cord-023095-4dannjjm 3300 18 0 0 CD cord-023095-4dannjjm 3300 19 - - SYM cord-023095-4dannjjm 3300 20 4 4 CD cord-023095-4dannjjm 3300 21 ) ) -RRB- cord-023095-4dannjjm 3300 22 ( ( -LRB- cord-023095-4dannjjm 3300 23 3 3 CD cord-023095-4dannjjm 3300 24 - - SYM cord-023095-4dannjjm 3300 25 10 10 CD cord-023095-4dannjjm 3300 26 ) ) -RRB- cord-023095-4dannjjm 3300 27 Ilium Ilium NNP cord-023095-4dannjjm 3300 28 , , , cord-023095-4dannjjm 3300 29 13 13 CD cord-023095-4dannjjm 3300 30 ga ga NNP cord-023095-4dannjjm 3300 31 6.1 6.1 CD cord-023095-4dannjjm 3300 32 AE AE NNP cord-023095-4dannjjm 3300 33 0.6 0.6 CD cord-023095-4dannjjm 3300 34 9.0 9.0 CD cord-023095-4dannjjm 3300 35 AE AE NNP cord-023095-4dannjjm 3300 36 0.7 0.7 CD cord-023095-4dannjjm 3300 37 1.9 1.9 CD cord-023095-4dannjjm 3300 38 AE AE NNP cord-023095-4dannjjm 3300 39 0.6 0.6 CD cord-023095-4dannjjm 3300 40 7.5 7.5 CD cord-023095-4dannjjm 3300 41 AE AE NNP cord-023095-4dannjjm 3300 42 0.8 0.8 CD cord-023095-4dannjjm 3300 43 0.2 0.2 CD cord-023095-4dannjjm 3300 44 AE AE NNP cord-023095-4dannjjm 3300 45 0.1 0.1 CD cord-023095-4dannjjm 3300 46 0.9 0.9 CD cord-023095-4dannjjm 3300 47 AE AE NNP cord-023095-4dannjjm 3300 48 0.1 0.1 CD cord-023095-4dannjjm 3300 49 Ã ã NN cord-023095-4dannjjm 3300 50 ( ( -LRB- cord-023095-4dannjjm 3300 51 4.5 4.5 CD cord-023095-4dannjjm 3300 52 - - SYM cord-023095-4dannjjm 3300 53 9.5 9.5 CD cord-023095-4dannjjm 3300 54 ) ) -RRB- cord-023095-4dannjjm 3300 55 ( ( -LRB- cord-023095-4dannjjm 3300 56 6 6 CD cord-023095-4dannjjm 3300 57 - - SYM cord-023095-4dannjjm 3300 58 12 12 CD cord-023095-4dannjjm 3300 59 ) ) -RRB- cord-023095-4dannjjm 3300 60 ( ( -LRB- cord-023095-4dannjjm 3300 61 0 0 CD cord-023095-4dannjjm 3300 62 - - SYM cord-023095-4dannjjm 3300 63 5 5 CD cord-023095-4dannjjm 3300 64 ) ) -RRB- cord-023095-4dannjjm 3300 65 ( ( -LRB- cord-023095-4dannjjm 3300 66 5 5 CD cord-023095-4dannjjm 3300 67 - - SYM cord-023095-4dannjjm 3300 68 12 12 CD cord-023095-4dannjjm 3300 69 ) ) -RRB- cord-023095-4dannjjm 3300 70 ( ( -LRB- cord-023095-4dannjjm 3300 71 0 0 CD cord-023095-4dannjjm 3300 72 - - SYM cord-023095-4dannjjm 3300 73 1 1 CD cord-023095-4dannjjm 3300 74 ) ) -RRB- cord-023095-4dannjjm 3300 75 ( ( -LRB- cord-023095-4dannjjm 3300 76 0 0 CD cord-023095-4dannjjm 3300 77 - - SYM cord-023095-4dannjjm 3300 78 1 1 CD cord-023095-4dannjjm 3300 79 ) ) -RRB- cord-023095-4dannjjm 3300 80 13 13 CD cord-023095-4dannjjm 3300 81 yrs yr NNS cord-023095-4dannjjm 3300 82 ) ) -RRB- cord-023095-4dannjjm 3300 83 . . . cord-023095-4dannjjm 3301 1 Presenting present VBG cord-023095-4dannjjm 3301 2 signs sign NNS cord-023095-4dannjjm 3301 3 included include VBD cord-023095-4dannjjm 3301 4 anorexia anorexia NN cord-023095-4dannjjm 3301 5 ( ( -LRB- cord-023095-4dannjjm 3301 6 31/50 31/50 CD cord-023095-4dannjjm 3301 7 ) ) -RRB- cord-023095-4dannjjm 3301 8 , , , cord-023095-4dannjjm 3301 9 vomiting vomit VBG cord-023095-4dannjjm 3301 10 ( ( -LRB- cord-023095-4dannjjm 3301 11 26/50 26/50 CD cord-023095-4dannjjm 3301 12 ) ) -RRB- cord-023095-4dannjjm 3301 13 , , , cord-023095-4dannjjm 3301 14 polydipsia polydipsia NN cord-023095-4dannjjm 3301 15 ( ( -LRB- cord-023095-4dannjjm 3301 16 9/50 9/50 CD cord-023095-4dannjjm 3301 17 ) ) -RRB- cord-023095-4dannjjm 3301 18 and and CC cord-023095-4dannjjm 3301 19 neurologic neurologic JJ cord-023095-4dannjjm 3301 20 signs sign NNS cord-023095-4dannjjm 3301 21 ( ( -LRB- cord-023095-4dannjjm 3301 22 6/50 6/50 CD cord-023095-4dannjjm 3301 23 Granulomatous granulomatous JJ cord-023095-4dannjjm 3301 24 hepatitis hepatitis NN cord-023095-4dannjjm 3301 25 ( ( -LRB- cord-023095-4dannjjm 3301 26 GH GH NNP cord-023095-4dannjjm 3301 27 ) ) -RRB- cord-023095-4dannjjm 3301 28 is be VBZ cord-023095-4dannjjm 3301 29 a a DT cord-023095-4dannjjm 3301 30 histopathological histopathological JJ cord-023095-4dannjjm 3301 31 diagnosis diagnosis NN cord-023095-4dannjjm 3301 32 characterized characterize VBN cord-023095-4dannjjm 3301 33 by by IN cord-023095-4dannjjm 3301 34 focal focal JJ cord-023095-4dannjjm 3301 35 aggregations aggregation NNS cord-023095-4dannjjm 3301 36 of of IN cord-023095-4dannjjm 3301 37 activated activate VBN cord-023095-4dannjjm 3301 38 macrophages macrophage NNS cord-023095-4dannjjm 3301 39 mixed mix VBN cord-023095-4dannjjm 3301 40 with with IN cord-023095-4dannjjm 3301 41 other other JJ cord-023095-4dannjjm 3301 42 inflammatory inflammatory JJ cord-023095-4dannjjm 3301 43 cells cell NNS cord-023095-4dannjjm 3301 44 that that WDT cord-023095-4dannjjm 3301 45 is be VBZ cord-023095-4dannjjm 3301 46 usually usually RB cord-023095-4dannjjm 3301 47 part part NN cord-023095-4dannjjm 3301 48 of of IN cord-023095-4dannjjm 3301 49 a a DT cord-023095-4dannjjm 3301 50 systemic systemic JJ cord-023095-4dannjjm 3301 51 disease disease NN cord-023095-4dannjjm 3301 52 process process NN cord-023095-4dannjjm 3301 53 ( ( -LRB- cord-023095-4dannjjm 3301 54 WSAVA WSAVA NNP cord-023095-4dannjjm 3301 55 ) ) -RRB- cord-023095-4dannjjm 3301 56 . . . cord-023095-4dannjjm 3302 1 Published publish VBN cord-023095-4dannjjm 3302 2 case case NN cord-023095-4dannjjm 3302 3 reports report NNS cord-023095-4dannjjm 3302 4 describe describe VBP cord-023095-4dannjjm 3302 5 many many JJ cord-023095-4dannjjm 3302 6 potential potential JJ cord-023095-4dannjjm 3302 7 infectious infectious JJ cord-023095-4dannjjm 3302 8 causes cause NNS cord-023095-4dannjjm 3302 9 , , , cord-023095-4dannjjm 3302 10 but but CC cord-023095-4dannjjm 3302 11 only only RB cord-023095-4dannjjm 3302 12 one one CD cord-023095-4dannjjm 3302 13 retrospective retrospective JJ cord-023095-4dannjjm 3302 14 study study NN cord-023095-4dannjjm 3302 15 involving involve VBG cord-023095-4dannjjm 3302 16 nine nine CD cord-023095-4dannjjm 3302 17 dogs dog NNS cord-023095-4dannjjm 3302 18 with with IN cord-023095-4dannjjm 3302 19 GH GH NNP cord-023095-4dannjjm 3302 20 has have VBZ cord-023095-4dannjjm 3302 21 detailed detail VBN cord-023095-4dannjjm 3302 22 clinically clinically RB cord-023095-4dannjjm 3302 23 relevant relevant JJ cord-023095-4dannjjm 3302 24 findings finding NNS cord-023095-4dannjjm 3302 25 . . . cord-023095-4dannjjm 3303 1 The the DT cord-023095-4dannjjm 3303 2 aims aim NNS cord-023095-4dannjjm 3303 3 of of IN cord-023095-4dannjjm 3303 4 this this DT cord-023095-4dannjjm 3303 5 study study NN cord-023095-4dannjjm 3303 6 were be VBD cord-023095-4dannjjm 3303 7 to to TO cord-023095-4dannjjm 3303 8 describe describe VB cord-023095-4dannjjm 3303 9 the the DT cord-023095-4dannjjm 3303 10 clinical clinical JJ cord-023095-4dannjjm 3303 11 and and CC cord-023095-4dannjjm 3303 12 clinicopathologic clinicopathologic JJ cord-023095-4dannjjm 3303 13 findings finding NNS cord-023095-4dannjjm 3303 14 in in IN cord-023095-4dannjjm 3303 15 dogs dog NNS cord-023095-4dannjjm 3303 16 with with IN cord-023095-4dannjjm 3303 17 a a DT cord-023095-4dannjjm 3303 18 histopathological histopathological JJ cord-023095-4dannjjm 3303 19 diagnosis diagnosis NN cord-023095-4dannjjm 3303 20 of of IN cord-023095-4dannjjm 3303 21 GH GH NNP cord-023095-4dannjjm 3303 22 , , , cord-023095-4dannjjm 3303 23 and and CC cord-023095-4dannjjm 3303 24 to to TO cord-023095-4dannjjm 3303 25 identify identify VB cord-023095-4dannjjm 3303 26 infectious infectious JJ cord-023095-4dannjjm 3303 27 agents agent NNS cord-023095-4dannjjm 3303 28 using use VBG cord-023095-4dannjjm 3303 29 differential differential JJ cord-023095-4dannjjm 3303 30 staining staining NN cord-023095-4dannjjm 3303 31 techniques technique NNS cord-023095-4dannjjm 3303 32 , , , cord-023095-4dannjjm 3303 33 PCR PCR NNP cord-023095-4dannjjm 3303 34 , , , cord-023095-4dannjjm 3303 35 and and CC cord-023095-4dannjjm 3303 36 fluorescence fluorescence NN cord-023095-4dannjjm 3303 37 in in IN cord-023095-4dannjjm 3303 38 - - HYPH cord-023095-4dannjjm 3303 39 situ situ NN cord-023095-4dannjjm 3303 40 hybridization hybridization NN cord-023095-4dannjjm 3303 41 ( ( -LRB- cord-023095-4dannjjm 3303 42 FISH fish NN cord-023095-4dannjjm 3303 43 ) ) -RRB- cord-023095-4dannjjm 3303 44 in in IN cord-023095-4dannjjm 3303 45 archival archival JJ cord-023095-4dannjjm 3303 46 paraffin paraffin NN cord-023095-4dannjjm 3303 47 - - HYPH cord-023095-4dannjjm 3303 48 embedded embed VBN cord-023095-4dannjjm 3303 49 tissues tissue NNS cord-023095-4dannjjm 3303 50 from from IN cord-023095-4dannjjm 3303 51 dogs dog NNS cord-023095-4dannjjm 3303 52 with with IN cord-023095-4dannjjm 3303 53 GH GH NNP cord-023095-4dannjjm 3303 54 . . . cord-023095-4dannjjm 3304 1 Medical medical JJ cord-023095-4dannjjm 3304 2 records record NNS cord-023095-4dannjjm 3304 3 of of IN cord-023095-4dannjjm 3304 4 dogs dog NNS cord-023095-4dannjjm 3304 5 with with IN cord-023095-4dannjjm 3304 6 a a DT cord-023095-4dannjjm 3304 7 histopathological histopathological JJ cord-023095-4dannjjm 3304 8 diagnosis diagnosis NN cord-023095-4dannjjm 3304 9 of of IN cord-023095-4dannjjm 3304 10 GH GH NNP cord-023095-4dannjjm 3304 11 ( ( -LRB- cord-023095-4dannjjm 3304 12 n n NN cord-023095-4dannjjm 3304 13 5 5 CD cord-023095-4dannjjm 3304 14 22 22 CD cord-023095-4dannjjm 3304 15 ) ) -RRB- cord-023095-4dannjjm 3304 16 were be VBD cord-023095-4dannjjm 3304 17 reviewed review VBN cord-023095-4dannjjm 3304 18 and and CC cord-023095-4dannjjm 3304 19 signalment signalment JJ cord-023095-4dannjjm 3304 20 , , , cord-023095-4dannjjm 3304 21 historical historical JJ cord-023095-4dannjjm 3304 22 toxin toxin NN cord-023095-4dannjjm 3304 23 exposure exposure NN cord-023095-4dannjjm 3304 24 or or CC cord-023095-4dannjjm 3304 25 evidence evidence NN cord-023095-4dannjjm 3304 26 of of IN cord-023095-4dannjjm 3304 27 other other JJ cord-023095-4dannjjm 3304 28 systemic systemic JJ cord-023095-4dannjjm 3304 29 diseases disease NNS cord-023095-4dannjjm 3304 30 , , , cord-023095-4dannjjm 3304 31 clinical clinical JJ cord-023095-4dannjjm 3304 32 signs sign NNS cord-023095-4dannjjm 3304 33 , , , cord-023095-4dannjjm 3304 34 physical physical JJ cord-023095-4dannjjm 3304 35 exam exam NN cord-023095-4dannjjm 3304 36 findings finding NNS cord-023095-4dannjjm 3304 37 , , , cord-023095-4dannjjm 3304 38 clinicopathologic clinicopathologic JJ cord-023095-4dannjjm 3304 39 test test NN cord-023095-4dannjjm 3304 40 results result NNS cord-023095-4dannjjm 3304 41 , , , cord-023095-4dannjjm 3304 42 imaging image VBG cord-023095-4dannjjm 3304 43 findings finding NNS cord-023095-4dannjjm 3304 44 , , , cord-023095-4dannjjm 3304 45 concurrent concurrent JJ cord-023095-4dannjjm 3304 46 diagnoses diagnosis NNS cord-023095-4dannjjm 3304 47 , , , cord-023095-4dannjjm 3304 48 treatments treatment NNS cord-023095-4dannjjm 3304 49 administered administer VBN cord-023095-4dannjjm 3304 50 , , , cord-023095-4dannjjm 3304 51 and and CC cord-023095-4dannjjm 3304 52 case case NN cord-023095-4dannjjm 3304 53 outcome outcome NN cord-023095-4dannjjm 3304 54 , , , cord-023095-4dannjjm 3304 55 when when WRB cord-023095-4dannjjm 3304 56 available available JJ cord-023095-4dannjjm 3304 57 , , , cord-023095-4dannjjm 3304 58 were be VBD cord-023095-4dannjjm 3304 59 extracted extract VBN cord-023095-4dannjjm 3304 60 and and CC cord-023095-4dannjjm 3304 61 summarized summarize VBN cord-023095-4dannjjm 3304 62 . . . cord-023095-4dannjjm 3305 1 Twelve twelve CD cord-023095-4dannjjm 3305 2 archival archival JJ cord-023095-4dannjjm 3305 3 formalin formalin NN cord-023095-4dannjjm 3305 4 - - HYPH cord-023095-4dannjjm 3305 5 fixed fix VBN cord-023095-4dannjjm 3305 6 , , , cord-023095-4dannjjm 3305 7 paraffin paraffin NN cord-023095-4dannjjm 3305 8 - - HYPH cord-023095-4dannjjm 3305 9 embedded embed VBN cord-023095-4dannjjm 3305 10 hepatic hepatic JJ cord-023095-4dannjjm 3305 11 tissue tissue NN cord-023095-4dannjjm 3305 12 samples sample NNS cord-023095-4dannjjm 3305 13 were be VBD cord-023095-4dannjjm 3305 14 available available JJ cord-023095-4dannjjm 3305 15 for for IN cord-023095-4dannjjm 3305 16 special special JJ cord-023095-4dannjjm 3305 17 staining staining NN cord-023095-4dannjjm 3305 18 and and CC cord-023095-4dannjjm 3305 19 molecular molecular JJ cord-023095-4dannjjm 3305 20 diagnostic diagnostic JJ cord-023095-4dannjjm 3305 21 testing testing NN cord-023095-4dannjjm 3305 22 . . . cord-023095-4dannjjm 3306 1 Two two CD cord-023095-4dannjjm 3306 2 of of IN cord-023095-4dannjjm 3306 3 these these DT cord-023095-4dannjjm 3306 4 samples sample NNS cord-023095-4dannjjm 3306 5 had have VBD cord-023095-4dannjjm 3306 6 sufficient sufficient JJ cord-023095-4dannjjm 3306 7 tissue tissue NN cord-023095-4dannjjm 3306 8 for for IN cord-023095-4dannjjm 3306 9 only only JJ cord-023095-4dannjjm 3306 10 PCR PCR NNP cord-023095-4dannjjm 3306 11 . . . cord-023095-4dannjjm 3307 1 The the DT cord-023095-4dannjjm 3307 2 mean mean JJ cord-023095-4dannjjm 3307 3 age age NN cord-023095-4dannjjm 3307 4 of of IN cord-023095-4dannjjm 3307 5 dogs dog NNS cord-023095-4dannjjm 3307 6 with with IN cord-023095-4dannjjm 3307 7 GH GH NNP cord-023095-4dannjjm 3307 8 was be VBD cord-023095-4dannjjm 3307 9 7 7 CD cord-023095-4dannjjm 3307 10 years year NNS cord-023095-4dannjjm 3307 11 ( ( -LRB- cord-023095-4dannjjm 3307 12 median median JJ cord-023095-4dannjjm 3307 13 6.5 6.5 CD cord-023095-4dannjjm 3307 14 years year NNS cord-023095-4dannjjm 3307 15 ; ; : cord-023095-4dannjjm 3307 16 range range VBP cord-023095-4dannjjm 3307 17 2 2 CD cord-023095-4dannjjm 3307 18 to to TO cord-023095-4dannjjm 3307 19 17 17 CD cord-023095-4dannjjm 3307 20 years year NNS cord-023095-4dannjjm 3307 21 ) ) -RRB- cord-023095-4dannjjm 3307 22 and and CC cord-023095-4dannjjm 3307 23 included include VBD cord-023095-4dannjjm 3307 24 12 12 CD cord-023095-4dannjjm 3307 25 males male NNS cord-023095-4dannjjm 3307 26 and and CC cord-023095-4dannjjm 3307 27 10 10 CD cord-023095-4dannjjm 3307 28 females female NNS cord-023095-4dannjjm 3307 29 representing represent VBG cord-023095-4dannjjm 3307 30 14 14 CD cord-023095-4dannjjm 3307 31 different different JJ cord-023095-4dannjjm 3307 32 breeds breed NNS cord-023095-4dannjjm 3307 33 . . . cord-023095-4dannjjm 3308 1 Common common JJ cord-023095-4dannjjm 3308 2 presenting present VBG cord-023095-4dannjjm 3308 3 complaints complaint NNS cord-023095-4dannjjm 3308 4 included include VBD cord-023095-4dannjjm 3308 5 inappetance inappetance NN cord-023095-4dannjjm 3308 6 or or CC cord-023095-4dannjjm 3308 7 anorexia anorexia NN cord-023095-4dannjjm 3308 8 ( ( -LRB- cord-023095-4dannjjm 3308 9 n n NN cord-023095-4dannjjm 3308 10 5 5 CD cord-023095-4dannjjm 3308 11 12 12 CD cord-023095-4dannjjm 3308 12 ) ) -RRB- cord-023095-4dannjjm 3308 13 , , , cord-023095-4dannjjm 3308 14 weight weight NN cord-023095-4dannjjm 3308 15 loss loss NN cord-023095-4dannjjm 3308 16 ( ( -LRB- cord-023095-4dannjjm 3308 17 n n NN cord-023095-4dannjjm 3308 18 5 5 CD cord-023095-4dannjjm 3308 19 11 11 CD cord-023095-4dannjjm 3308 20 ) ) -RRB- cord-023095-4dannjjm 3308 21 , , , cord-023095-4dannjjm 3308 22 lethargy lethargy NN cord-023095-4dannjjm 3308 23 ( ( -LRB- cord-023095-4dannjjm 3308 24 n n NN cord-023095-4dannjjm 3308 25 5 5 CD cord-023095-4dannjjm 3308 26 9 9 CD cord-023095-4dannjjm 3308 27 ) ) -RRB- cord-023095-4dannjjm 3308 28 , , , cord-023095-4dannjjm 3308 29 fever fever NN cord-023095-4dannjjm 3308 30 ( ( -LRB- cord-023095-4dannjjm 3308 31 n n NN cord-023095-4dannjjm 3308 32 5 5 CD cord-023095-4dannjjm 3308 33 8) 8) NNP cord-023095-4dannjjm 3308 34 , , , cord-023095-4dannjjm 3308 35 and and CC cord-023095-4dannjjm 3308 36 vomiting vomiting NN cord-023095-4dannjjm 3308 37 ( ( -LRB- cord-023095-4dannjjm 3308 38 n n NN cord-023095-4dannjjm 3308 39 5 5 CD cord-023095-4dannjjm 3308 40 8) 8) NN cord-023095-4dannjjm 3308 41 . . . cord-023095-4dannjjm 3309 1 High high JJ cord-023095-4dannjjm 3309 2 mixed mixed JJ cord-023095-4dannjjm 3309 3 liver liver NN cord-023095-4dannjjm 3309 4 enzyme enzyme NN cord-023095-4dannjjm 3309 5 activity activity NN cord-023095-4dannjjm 3309 6 ( ( -LRB- cord-023095-4dannjjm 3309 7 14/22 14/22 CD cord-023095-4dannjjm 3309 8 ) ) -RRB- cord-023095-4dannjjm 3309 9 was be VBD cord-023095-4dannjjm 3309 10 the the DT cord-023095-4dannjjm 3309 11 most most RBS cord-023095-4dannjjm 3309 12 common common JJ cord-023095-4dannjjm 3309 13 clinicopathologic clinicopathologic JJ cord-023095-4dannjjm 3309 14 abnormality abnormality NN cord-023095-4dannjjm 3309 15 . . . cord-023095-4dannjjm 3310 1 Leukemia leukemia NN cord-023095-4dannjjm 3310 2 was be VBD cord-023095-4dannjjm 3310 3 diagnosed diagnose VBN cord-023095-4dannjjm 3310 4 in in IN cord-023095-4dannjjm 3310 5 one one CD cord-023095-4dannjjm 3310 6 dog dog NN cord-023095-4dannjjm 3310 7 and and CC cord-023095-4dannjjm 3310 8 copper copper NN cord-023095-4dannjjm 3310 9 - - HYPH cord-023095-4dannjjm 3310 10 associated associate VBN cord-023095-4dannjjm 3310 11 hepatopathy hepatopathy NNP cord-023095-4dannjjm 3310 12 in in IN cord-023095-4dannjjm 3310 13 6 6 CD cord-023095-4dannjjm 3310 14 dogs dog NNS cord-023095-4dannjjm 3310 15 . . . cord-023095-4dannjjm 3311 1 No no DT cord-023095-4dannjjm 3311 2 infectious infectious JJ cord-023095-4dannjjm 3311 3 agents agent NNS cord-023095-4dannjjm 3311 4 were be VBD cord-023095-4dannjjm 3311 5 identified identify VBN cord-023095-4dannjjm 3311 6 using use VBG cord-023095-4dannjjm 3311 7 differential differential JJ cord-023095-4dannjjm 3311 8 staining staining NN cord-023095-4dannjjm 3311 9 techniques technique NNS cord-023095-4dannjjm 3311 10 . . . cord-023095-4dannjjm 3312 1 Bartonella Bartonella NNP cord-023095-4dannjjm 3312 2 species species NN cord-023095-4dannjjm 3312 3 DNA DNA NNP cord-023095-4dannjjm 3312 4 was be VBD cord-023095-4dannjjm 3312 5 not not RB cord-023095-4dannjjm 3312 6 PCR PCR NNP cord-023095-4dannjjm 3312 7 amplified amplify VBN cord-023095-4dannjjm 3312 8 from from IN cord-023095-4dannjjm 3312 9 the the DT cord-023095-4dannjjm 3312 10 extracted extract VBN cord-023095-4dannjjm 3312 11 archival archival JJ cord-023095-4dannjjm 3312 12 tissue tissue NN cord-023095-4dannjjm 3312 13 . . . cord-023095-4dannjjm 3313 1 Furthermore furthermore RB cord-023095-4dannjjm 3313 2 , , , cord-023095-4dannjjm 3313 3 no no DT cord-023095-4dannjjm 3313 4 bacteria bacteria NNS cord-023095-4dannjjm 3313 5 were be VBD cord-023095-4dannjjm 3313 6 identified identify VBN cord-023095-4dannjjm 3313 7 by by IN cord-023095-4dannjjm 3313 8 means mean NNS cord-023095-4dannjjm 3313 9 of of IN cord-023095-4dannjjm 3313 10 FISH fish NN cord-023095-4dannjjm 3313 11 using use VBG cord-023095-4dannjjm 3313 12 a a DT cord-023095-4dannjjm 3313 13 universal universal JJ cord-023095-4dannjjm 3313 14 eubacterial eubacterial JJ cord-023095-4dannjjm 3313 15 probe probe NN cord-023095-4dannjjm 3313 16 . . . cord-023095-4dannjjm 3314 1 These these DT cord-023095-4dannjjm 3314 2 data datum NNS cord-023095-4dannjjm 3314 3 suggest suggest VBP cord-023095-4dannjjm 3314 4 a a DT cord-023095-4dannjjm 3314 5 possible possible JJ cord-023095-4dannjjm 3314 6 role role NN cord-023095-4dannjjm 3314 7 for for IN cord-023095-4dannjjm 3314 8 copper copper NN cord-023095-4dannjjm 3314 9 accumulation accumulation NN cord-023095-4dannjjm 3314 10 in in IN cord-023095-4dannjjm 3314 11 the the DT cord-023095-4dannjjm 3314 12 genesis genesis NN cord-023095-4dannjjm 3314 13 of of IN cord-023095-4dannjjm 3314 14 GH GH NNP cord-023095-4dannjjm 3314 15 in in IN cord-023095-4dannjjm 3314 16 dogs dog NNS cord-023095-4dannjjm 3314 17 and and CC cord-023095-4dannjjm 3314 18 support support VB cord-023095-4dannjjm 3314 19 further further JJ cord-023095-4dannjjm 3314 20 evaluation evaluation NN cord-023095-4dannjjm 3314 21 of of IN cord-023095-4dannjjm 3314 22 dogs dog NNS cord-023095-4dannjjm 3314 23 with with IN cord-023095-4dannjjm 3314 24 GH GH NNP cord-023095-4dannjjm 3314 25 for for IN cord-023095-4dannjjm 3314 26 evidence evidence NN cord-023095-4dannjjm 3314 27 of of IN cord-023095-4dannjjm 3314 28 copper copper NN cord-023095-4dannjjm 3314 29 - - HYPH cord-023095-4dannjjm 3314 30 associated associate VBN cord-023095-4dannjjm 3314 31 hepatopathy hepatopathy NNP cord-023095-4dannjjm 3314 32 . . . cord-023095-4dannjjm 3315 1 Future future JJ cord-023095-4dannjjm 3315 2 studies study NNS cord-023095-4dannjjm 3315 3 should should MD cord-023095-4dannjjm 3315 4 include include VB cord-023095-4dannjjm 3315 5 detailed detailed JJ cord-023095-4dannjjm 3315 6 environmental environmental JJ cord-023095-4dannjjm 3315 7 histories history NNS cord-023095-4dannjjm 3315 8 , , , cord-023095-4dannjjm 3315 9 the the DT cord-023095-4dannjjm 3315 10 collection collection NN cord-023095-4dannjjm 3315 11 of of IN cord-023095-4dannjjm 3315 12 adequate adequate JJ cord-023095-4dannjjm 3315 13 sample sample NN cord-023095-4dannjjm 3315 14 volumes volume NNS cord-023095-4dannjjm 3315 15 for for IN cord-023095-4dannjjm 3315 16 quantification quantification NN cord-023095-4dannjjm 3315 17 of of IN cord-023095-4dannjjm 3315 18 hepatic hepatic JJ cord-023095-4dannjjm 3315 19 copper copper NN cord-023095-4dannjjm 3315 20 content content NN cord-023095-4dannjjm 3315 21 and and CC cord-023095-4dannjjm 3315 22 the the DT cord-023095-4dannjjm 3315 23 examination examination NN cord-023095-4dannjjm 3315 24 of of IN cord-023095-4dannjjm 3315 25 frozen frozen JJ cord-023095-4dannjjm 3315 26 tissues tissue NNS cord-023095-4dannjjm 3315 27 using use VBG cord-023095-4dannjjm 3315 28 novel novel JJ cord-023095-4dannjjm 3315 29 molecular molecular JJ cord-023095-4dannjjm 3315 30 diagnostic diagnostic JJ cord-023095-4dannjjm 3315 31 platforms platform NNS cord-023095-4dannjjm 3315 32 . . . cord-023095-4dannjjm 3316 1 Hepatocyte Hepatocyte NNP cord-023095-4dannjjm 3316 2 copper copper NN cord-023095-4dannjjm 3316 3 and and CC cord-023095-4dannjjm 3316 4 iron iron NN cord-023095-4dannjjm 3316 5 accumulation accumulation NN cord-023095-4dannjjm 3316 6 contribute contribute VBP cord-023095-4dannjjm 3316 7 to to IN cord-023095-4dannjjm 3316 8 cell cell NN cord-023095-4dannjjm 3316 9 loss loss NN cord-023095-4dannjjm 3316 10 , , , cord-023095-4dannjjm 3316 11 inflammation inflammation NN cord-023095-4dannjjm 3316 12 , , , cord-023095-4dannjjm 3316 13 and and CC cord-023095-4dannjjm 3316 14 fibrosis fibrosis NN cord-023095-4dannjjm 3316 15 . . . cord-023095-4dannjjm 3317 1 The the DT cord-023095-4dannjjm 3317 2 purpose purpose NN cord-023095-4dannjjm 3317 3 of of IN cord-023095-4dannjjm 3317 4 this this DT cord-023095-4dannjjm 3317 5 study study NN cord-023095-4dannjjm 3317 6 was be VBD cord-023095-4dannjjm 3317 7 to to TO cord-023095-4dannjjm 3317 8 compare compare VB cord-023095-4dannjjm 3317 9 copper copper NN cord-023095-4dannjjm 3317 10 and and CC cord-023095-4dannjjm 3317 11 iron iron NN cord-023095-4dannjjm 3317 12 accumulation accumulation NN cord-023095-4dannjjm 3317 13 in in IN cord-023095-4dannjjm 3317 14 feline feline JJ cord-023095-4dannjjm 3317 15 liver liver NN cord-023095-4dannjjm 3317 16 samples sample NNS cord-023095-4dannjjm 3317 17 with with IN cord-023095-4dannjjm 3317 18 different different JJ cord-023095-4dannjjm 3317 19 disease disease NN cord-023095-4dannjjm 3317 20 processes process NNS cord-023095-4dannjjm 3317 21 . . . cord-023095-4dannjjm 3318 1 Liver liver NN cord-023095-4dannjjm 3318 2 biopsies biopsy NNS cord-023095-4dannjjm 3318 3 ( ( -LRB- cord-023095-4dannjjm 3318 4 n n NN cord-023095-4dannjjm 3318 5 5 5 CD cord-023095-4dannjjm 3318 6 104 104 CD cord-023095-4dannjjm 3318 7 ) ) -RRB- cord-023095-4dannjjm 3318 8 submitted submit VBN cord-023095-4dannjjm 3318 9 between between IN cord-023095-4dannjjm 3318 10 July July NNP cord-023095-4dannjjm 3318 11 1 1 CD cord-023095-4dannjjm 3318 12 , , , cord-023095-4dannjjm 3318 13 2007 2007 CD cord-023095-4dannjjm 3318 14 and and CC cord-023095-4dannjjm 3318 15 June June NNP cord-023095-4dannjjm 3318 16 30 30 CD cord-023095-4dannjjm 3318 17 , , , cord-023095-4dannjjm 3318 18 2009 2009 CD cord-023095-4dannjjm 3318 19 were be VBD cord-023095-4dannjjm 3318 20 evaluated evaluate VBN cord-023095-4dannjjm 3318 21 using use VBG cord-023095-4dannjjm 3318 22 WSAVA WSAVA NNP cord-023095-4dannjjm 3318 23 guidelines guideline NNS cord-023095-4dannjjm 3318 24 and and CC cord-023095-4dannjjm 3318 25 categorized categorize VBN cord-023095-4dannjjm 3318 26 as as IN cord-023095-4dannjjm 3318 27 non non JJ cord-023095-4dannjjm 3318 28 - - JJ cord-023095-4dannjjm 3318 29 hepatic hepatic JJ cord-023095-4dannjjm 3318 30 / / SYM cord-023095-4dannjjm 3318 31 normal normal JJ cord-023095-4dannjjm 3318 32 , , , cord-023095-4dannjjm 3318 33 congenital congenital JJ cord-023095-4dannjjm 3318 34 , , , cord-023095-4dannjjm 3318 35 inflammatory inflammatory JJ cord-023095-4dannjjm 3318 36 / / SYM cord-023095-4dannjjm 3318 37 infectious infectious JJ cord-023095-4dannjjm 3318 38 , , , cord-023095-4dannjjm 3318 39 neoplastic neoplastic JJ cord-023095-4dannjjm 3318 40 , , , cord-023095-4dannjjm 3318 41 and and CC cord-023095-4dannjjm 3318 42 other other JJ cord-023095-4dannjjm 3318 43 . . . cord-023095-4dannjjm 3319 1 Copper copper NN cord-023095-4dannjjm 3319 2 ( ( -LRB- cord-023095-4dannjjm 3319 3 by by IN cord-023095-4dannjjm 3319 4 rubeanic rubeanic JJ cord-023095-4dannjjm 3319 5 acid acid NN cord-023095-4dannjjm 3319 6 ) ) -RRB- cord-023095-4dannjjm 3319 7 and and CC cord-023095-4dannjjm 3319 8 iron iron NN cord-023095-4dannjjm 3319 9 ( ( -LRB- cord-023095-4dannjjm 3319 10 by by IN cord-023095-4dannjjm 3319 11 Prussian prussian JJ cord-023095-4dannjjm 3319 12 blue blue JJ cord-023095-4dannjjm 3319 13 ) ) -RRB- cord-023095-4dannjjm 3319 14 accumulation accumulation NN cord-023095-4dannjjm 3319 15 were be VBD cord-023095-4dannjjm 3319 16 graded grade VBN cord-023095-4dannjjm 3319 17 by by IN cord-023095-4dannjjm 3319 18 increasing increase VBG cord-023095-4dannjjm 3319 19 amounts amount NNS cord-023095-4dannjjm 3319 20 ( ( -LRB- cord-023095-4dannjjm 3319 21 0 0 CD cord-023095-4dannjjm 3319 22 - - SYM cord-023095-4dannjjm 3319 23 3 3 CD cord-023095-4dannjjm 3319 24 ) ) -RRB- cord-023095-4dannjjm 3319 25 and and CC cord-023095-4dannjjm 3319 26 location location NN cord-023095-4dannjjm 3319 27 ( ( -LRB- cord-023095-4dannjjm 3319 28 centrilobular centrilobular NNP cord-023095-4dannjjm 3319 29 5 5 CD cord-023095-4dannjjm 3319 30 CL CL NNP cord-023095-4dannjjm 3319 31 , , , cord-023095-4dannjjm 3319 32 midzonal midzonal JJ cord-023095-4dannjjm 3319 33 5 5 CD cord-023095-4dannjjm 3319 34 MZ MZ NNP cord-023095-4dannjjm 3319 35 , , , cord-023095-4dannjjm 3319 36 periportal periportal NNP cord-023095-4dannjjm 3319 37 5 5 CD cord-023095-4dannjjm 3319 38 PP PP NNP cord-023095-4dannjjm 3319 39 , , , cord-023095-4dannjjm 3319 40 random random JJ cord-023095-4dannjjm 3319 41 5 5 CD cord-023095-4dannjjm 3319 42 R r NN cord-023095-4dannjjm 3319 43 ) ) -RRB- cord-023095-4dannjjm 3319 44 . . . cord-023095-4dannjjm 3320 1 Associations association NNS cord-023095-4dannjjm 3320 2 between between IN cord-023095-4dannjjm 3320 3 metal metal NN cord-023095-4dannjjm 3320 4 scores score NNS cord-023095-4dannjjm 3320 5 and and CC cord-023095-4dannjjm 3320 6 diagnosis diagnosis NN cord-023095-4dannjjm 3320 7 category category NN cord-023095-4dannjjm 3320 8 were be VBD cord-023095-4dannjjm 3320 9 assessed assess VBN cord-023095-4dannjjm 3320 10 using use VBG cord-023095-4dannjjm 3320 11 the the DT cord-023095-4dannjjm 3320 12 Kruskal Kruskal NNP cord-023095-4dannjjm 3320 13 - - HYPH cord-023095-4dannjjm 3320 14 Wallis Wallis NNP cord-023095-4dannjjm 3320 15 test test NN cord-023095-4dannjjm 3320 16 . . . cord-023095-4dannjjm 3321 1 Histologic Histologic NNP cord-023095-4dannjjm 3321 2 diagnoses diagnosis NNS cord-023095-4dannjjm 3321 3 were be VBD cord-023095-4dannjjm 3321 4 non non JJ cord-023095-4dannjjm 3321 5 - - JJ cord-023095-4dannjjm 3321 6 hepatic hepatic JJ cord-023095-4dannjjm 3321 7 / / SYM cord-023095-4dannjjm 3321 8 normal normal JJ cord-023095-4dannjjm 3322 1 ( ( -LRB- cord-023095-4dannjjm 3322 2 n n NN cord-023095-4dannjjm 3322 3 5 5 CD cord-023095-4dannjjm 3322 4 12 12 CD cord-023095-4dannjjm 3322 5 ) ) -RRB- cord-023095-4dannjjm 3323 1 , , , cord-023095-4dannjjm 3323 2 congenital congenital JJ cord-023095-4dannjjm 3323 3 ( ( -LRB- cord-023095-4dannjjm 3323 4 n n NN cord-023095-4dannjjm 3323 5 5 5 CD cord-023095-4dannjjm 3323 6 6 6 CD cord-023095-4dannjjm 3323 7 ) ) -RRB- cord-023095-4dannjjm 3323 8 , , , cord-023095-4dannjjm 3323 9 neoplastic neoplastic JJ cord-023095-4dannjjm 3323 10 ( ( -LRB- cord-023095-4dannjjm 3323 11 n n NN cord-023095-4dannjjm 3323 12 5 5 CD cord-023095-4dannjjm 3323 13 16 16 CD cord-023095-4dannjjm 3323 14 ) ) -RRB- cord-023095-4dannjjm 3323 15 , , , cord-023095-4dannjjm 3323 16 infectious infectious JJ cord-023095-4dannjjm 3323 17 / / SYM cord-023095-4dannjjm 3323 18 inflammatory inflammatory JJ cord-023095-4dannjjm 3323 19 ( ( -LRB- cord-023095-4dannjjm 3323 20 n n NN cord-023095-4dannjjm 3323 21 5 5 CD cord-023095-4dannjjm 3323 22 39 39 CD cord-023095-4dannjjm 3323 23 ) ) -RRB- cord-023095-4dannjjm 3323 24 , , , cord-023095-4dannjjm 3323 25 and and CC cord-023095-4dannjjm 3323 26 other other JJ cord-023095-4dannjjm 3323 27 ( ( -LRB- cord-023095-4dannjjm 3323 28 n n NN cord-023095-4dannjjm 3323 29 5 5 CD cord-023095-4dannjjm 3323 30 31 31 CD cord-023095-4dannjjm 3323 31 ) ) -RRB- cord-023095-4dannjjm 3323 32 . . . cord-023095-4dannjjm 3324 1 Ninety ninety CD cord-023095-4dannjjm 3324 2 - - HYPH cord-023095-4dannjjm 3324 3 two two CD cord-023095-4dannjjm 3324 4 samples sample NNS cord-023095-4dannjjm 3324 5 were be VBD cord-023095-4dannjjm 3324 6 negative negative JJ cord-023095-4dannjjm 3324 7 for for IN cord-023095-4dannjjm 3324 8 copper copper NN cord-023095-4dannjjm 3324 9 ; ; , cord-023095-4dannjjm 3324 10 remaining remain VBG cord-023095-4dannjjm 3324 11 samples sample NNS cord-023095-4dannjjm 3324 12 were be VBD cord-023095-4dannjjm 3324 13 graded grade VBN cord-023095-4dannjjm 3324 14 1 1 CD cord-023095-4dannjjm 3325 1 ( ( -LRB- cord-023095-4dannjjm 3325 2 n n NN cord-023095-4dannjjm 3325 3 5 5 CD cord-023095-4dannjjm 3325 4 5 5 CD cord-023095-4dannjjm 3325 5 ) ) -RRB- cord-023095-4dannjjm 3325 6 , , , cord-023095-4dannjjm 3325 7 2 2 CD cord-023095-4dannjjm 3325 8 ( ( -LRB- cord-023095-4dannjjm 3325 9 n n NN cord-023095-4dannjjm 3325 10 5 5 CD cord-023095-4dannjjm 3325 11 6 6 CD cord-023095-4dannjjm 3325 12 ) ) -RRB- cord-023095-4dannjjm 3325 13 , , , cord-023095-4dannjjm 3325 14 and and CC cord-023095-4dannjjm 3325 15 3 3 LS cord-023095-4dannjjm 3325 16 ( ( -LRB- cord-023095-4dannjjm 3325 17 n n NN cord-023095-4dannjjm 3325 18 5 5 CD cord-023095-4dannjjm 3325 19 1 1 CD cord-023095-4dannjjm 3325 20 ) ) -RRB- cord-023095-4dannjjm 3325 21 . . . cord-023095-4dannjjm 3326 1 Histologic Histologic NNP cord-023095-4dannjjm 3326 2 diagnoses diagnosis NNS cord-023095-4dannjjm 3326 3 ( ( -LRB- cord-023095-4dannjjm 3326 4 pattern pattern NN cord-023095-4dannjjm 3326 5 ) ) -RRB- cord-023095-4dannjjm 3326 6 for for IN cord-023095-4dannjjm 3326 7 positive positive JJ cord-023095-4dannjjm 3326 8 samples sample NNS cord-023095-4dannjjm 3326 9 were be VBD cord-023095-4dannjjm 3326 10 congenital congenital JJ cord-023095-4dannjjm 3326 11 ( ( -LRB- cord-023095-4dannjjm 3326 12 1CL 1cl CD cord-023095-4dannjjm 3326 13 ) ) -RRB- cord-023095-4dannjjm 3326 14 , , , cord-023095-4dannjjm 3326 15 infectious infectious JJ cord-023095-4dannjjm 3326 16 / / SYM cord-023095-4dannjjm 3326 17 inflammatory inflammatory JJ cord-023095-4dannjjm 3326 18 ( ( -LRB- cord-023095-4dannjjm 3326 19 7 7 CD cord-023095-4dannjjm 3326 20 : : SYM cord-023095-4dannjjm 3326 21 2CL 2cl CD cord-023095-4dannjjm 3326 22 , , , cord-023095-4dannjjm 3326 23 1MZ 1mz CD cord-023095-4dannjjm 3326 24 , , , cord-023095-4dannjjm 3326 25 2PP 2pp CD cord-023095-4dannjjm 3326 26 , , , cord-023095-4dannjjm 3326 27 2R 2R NNP cord-023095-4dannjjm 3326 28 ) ) -RRB- cord-023095-4dannjjm 3326 29 , , , cord-023095-4dannjjm 3326 30 neoplastic neoplastic JJ cord-023095-4dannjjm 3326 31 ( ( -LRB- cord-023095-4dannjjm 3326 32 2PP 2pp CD cord-023095-4dannjjm 3326 33 ) ) -RRB- cord-023095-4dannjjm 3326 34 , , , cord-023095-4dannjjm 3326 35 and and CC cord-023095-4dannjjm 3326 36 other other JJ cord-023095-4dannjjm 3326 37 ( ( -LRB- cord-023095-4dannjjm 3326 38 2CL 2cl CD cord-023095-4dannjjm 3326 39 ) ) -RRB- cord-023095-4dannjjm 3326 40 . . . cord-023095-4dannjjm 3327 1 Iron iron NN cord-023095-4dannjjm 3327 2 staining staining NN cord-023095-4dannjjm 3327 3 was be VBD cord-023095-4dannjjm 3327 4 negative negative JJ cord-023095-4dannjjm 3327 5 in in IN cord-023095-4dannjjm 3327 6 18 18 CD cord-023095-4dannjjm 3327 7 samples sample NNS cord-023095-4dannjjm 3327 8 ; ; , cord-023095-4dannjjm 3327 9 remaining remain VBG cord-023095-4dannjjm 3327 10 samples sample NNS cord-023095-4dannjjm 3327 11 were be VBD cord-023095-4dannjjm 3327 12 graded grade VBN cord-023095-4dannjjm 3327 13 1 1 CD cord-023095-4dannjjm 3328 1 ( ( -LRB- cord-023095-4dannjjm 3328 2 n n NN cord-023095-4dannjjm 3328 3 5 5 CD cord-023095-4dannjjm 3328 4 38 38 CD cord-023095-4dannjjm 3328 5 ) ) -RRB- cord-023095-4dannjjm 3328 6 , , , cord-023095-4dannjjm 3328 7 2 2 CD cord-023095-4dannjjm 3328 8 ( ( -LRB- cord-023095-4dannjjm 3328 9 n n NN cord-023095-4dannjjm 3328 10 5 5 CD cord-023095-4dannjjm 3328 11 40 40 CD cord-023095-4dannjjm 3328 12 ) ) -RRB- cord-023095-4dannjjm 3328 13 , , , cord-023095-4dannjjm 3328 14 and and CC cord-023095-4dannjjm 3328 15 3 3 LS cord-023095-4dannjjm 3328 16 ( ( -LRB- cord-023095-4dannjjm 3328 17 n n NN cord-023095-4dannjjm 3328 18 5 5 CD cord-023095-4dannjjm 3328 19 8) 8) NN cord-023095-4dannjjm 3328 20 . . . cord-023095-4dannjjm 3329 1 Distribution distribution NN cord-023095-4dannjjm 3329 2 was be VBD cord-023095-4dannjjm 3329 3 primarily primarily RB cord-023095-4dannjjm 3329 4 CL CL NNP cord-023095-4dannjjm 3329 5 ( ( -LRB- cord-023095-4dannjjm 3329 6 n n NN cord-023095-4dannjjm 3329 7 5 5 CD cord-023095-4dannjjm 3329 8 38 38 CD cord-023095-4dannjjm 3329 9 ) ) -RRB- cord-023095-4dannjjm 3329 10 or or CC cord-023095-4dannjjm 3329 11 R r NN cord-023095-4dannjjm 3329 12 ( ( -LRB- cord-023095-4dannjjm 3329 13 n n NN cord-023095-4dannjjm 3329 14 5 5 CD cord-023095-4dannjjm 3329 15 33 33 CD cord-023095-4dannjjm 3329 16 ) ) -RRB- cord-023095-4dannjjm 3329 17 , , , cord-023095-4dannjjm 3329 18 though though IN cord-023095-4dannjjm 3329 19 MZ MZ NNP cord-023095-4dannjjm 3329 20 ( ( -LRB- cord-023095-4dannjjm 3329 21 n n NN cord-023095-4dannjjm 3329 22 5 5 CD cord-023095-4dannjjm 3329 23 13 13 CD cord-023095-4dannjjm 3329 24 ) ) -RRB- cord-023095-4dannjjm 3329 25 and and CC cord-023095-4dannjjm 3329 26 PP PP NNP cord-023095-4dannjjm 3329 27 ( ( -LRB- cord-023095-4dannjjm 3329 28 n n NN cord-023095-4dannjjm 3329 29 5 5 CD cord-023095-4dannjjm 3329 30 2 2 CD cord-023095-4dannjjm 3329 31 ) ) -RRB- cord-023095-4dannjjm 3329 32 distribution distribution NN cord-023095-4dannjjm 3329 33 occurred occur VBD cord-023095-4dannjjm 3329 34 . . . cord-023095-4dannjjm 3330 1 There there EX cord-023095-4dannjjm 3330 2 were be VBD cord-023095-4dannjjm 3330 3 no no DT cord-023095-4dannjjm 3330 4 significant significant JJ cord-023095-4dannjjm 3330 5 differences difference NNS cord-023095-4dannjjm 3330 6 by by IN cord-023095-4dannjjm 3330 7 Kruskal Kruskal NNP cord-023095-4dannjjm 3330 8 - - HYPH cord-023095-4dannjjm 3330 9 Wallis Wallis NNP cord-023095-4dannjjm 3330 10 analysis analysis NN cord-023095-4dannjjm 3330 11 for for IN cord-023095-4dannjjm 3330 12 amount amount NN cord-023095-4dannjjm 3330 13 or or CC cord-023095-4dannjjm 3330 14 location location NN cord-023095-4dannjjm 3330 15 of of IN cord-023095-4dannjjm 3330 16 hepatocellular hepatocellular JJ cord-023095-4dannjjm 3330 17 iron iron NN cord-023095-4dannjjm 3330 18 or or CC cord-023095-4dannjjm 3330 19 copper copper NN cord-023095-4dannjjm 3330 20 for for IN cord-023095-4dannjjm 3330 21 the the DT cord-023095-4dannjjm 3330 22 different different JJ cord-023095-4dannjjm 3330 23 disease disease NN cord-023095-4dannjjm 3330 24 categories category NNS cord-023095-4dannjjm 3330 25 . . . cord-023095-4dannjjm 3331 1 In in IN cord-023095-4dannjjm 3331 2 this this DT cord-023095-4dannjjm 3331 3 study study NN cord-023095-4dannjjm 3331 4 , , , cord-023095-4dannjjm 3331 5 copper copper NN cord-023095-4dannjjm 3331 6 accumulation accumulation NN cord-023095-4dannjjm 3331 7 was be VBD cord-023095-4dannjjm 3331 8 rare rare JJ cord-023095-4dannjjm 3331 9 , , , cord-023095-4dannjjm 3331 10 had have VBD cord-023095-4dannjjm 3331 11 variable variable JJ cord-023095-4dannjjm 3331 12 distribution distribution NN cord-023095-4dannjjm 3331 13 and and CC cord-023095-4dannjjm 3331 14 occurred occur VBD cord-023095-4dannjjm 3331 15 primarily primarily RB cord-023095-4dannjjm 3331 16 in in IN cord-023095-4dannjjm 3331 17 samples sample NNS cord-023095-4dannjjm 3331 18 with with IN cord-023095-4dannjjm 3331 19 inflammatory/ inflammatory/ HYPH cord-023095-4dannjjm 3331 20 infectious infectious JJ cord-023095-4dannjjm 3331 21 disease disease NN cord-023095-4dannjjm 3331 22 . . . cord-023095-4dannjjm 3332 1 In in IN cord-023095-4dannjjm 3332 2 contrast contrast NN cord-023095-4dannjjm 3332 3 , , , cord-023095-4dannjjm 3332 4 iron iron NN cord-023095-4dannjjm 3332 5 accumulation accumulation NN cord-023095-4dannjjm 3332 6 was be VBD cord-023095-4dannjjm 3332 7 common common JJ cord-023095-4dannjjm 3332 8 and and CC cord-023095-4dannjjm 3332 9 did do VBD cord-023095-4dannjjm 3332 10 not not RB cord-023095-4dannjjm 3332 11 correlate correlate VB cord-023095-4dannjjm 3332 12 with with IN cord-023095-4dannjjm 3332 13 disease disease NN cord-023095-4dannjjm 3332 14 category category NN cord-023095-4dannjjm 3332 15 . . . cord-023095-4dannjjm 3333 1 Further further JJ cord-023095-4dannjjm 3333 2 prospective prospective JJ cord-023095-4dannjjm 3333 3 evaluation evaluation NN cord-023095-4dannjjm 3333 4 of of IN cord-023095-4dannjjm 3333 5 copper copper NN cord-023095-4dannjjm 3333 6 and and CC cord-023095-4dannjjm 3333 7 iron iron NN cord-023095-4dannjjm 3333 8 accumulation accumulation NN cord-023095-4dannjjm 3333 9 in in IN cord-023095-4dannjjm 3333 10 feline feline JJ cord-023095-4dannjjm 3333 11 liver liver NN cord-023095-4dannjjm 3333 12 disease disease NN cord-023095-4dannjjm 3333 13 and and CC cord-023095-4dannjjm 3333 14 association association NN cord-023095-4dannjjm 3333 15 with with IN cord-023095-4dannjjm 3333 16 outcome outcome NN cord-023095-4dannjjm 3333 17 may may MD cord-023095-4dannjjm 3333 18 be be VB cord-023095-4dannjjm 3333 19 warranted warrant VBN cord-023095-4dannjjm 3333 20 . . . cord-023095-4dannjjm 3334 1 Chronic chronic JJ cord-023095-4dannjjm 3334 2 hepatitis hepatitis NN cord-023095-4dannjjm 3334 3 ( ( -LRB- cord-023095-4dannjjm 3334 4 CH CH NNP cord-023095-4dannjjm 3334 5 ) ) -RRB- cord-023095-4dannjjm 3334 6 in in IN cord-023095-4dannjjm 3334 7 dogs dog NNS cord-023095-4dannjjm 3334 8 is be VBZ cord-023095-4dannjjm 3334 9 a a DT cord-023095-4dannjjm 3334 10 progressive progressive JJ cord-023095-4dannjjm 3334 11 condition condition NN cord-023095-4dannjjm 3334 12 without without IN cord-023095-4dannjjm 3334 13 clearly clearly RB cord-023095-4dannjjm 3334 14 defined define VBN cord-023095-4dannjjm 3334 15 treatment treatment NN cord-023095-4dannjjm 3334 16 . . . cord-023095-4dannjjm 3335 1 Glucocorticoids Glucocorticoids NNP cord-023095-4dannjjm 3335 2 are be VBP cord-023095-4dannjjm 3335 3 commonly commonly RB cord-023095-4dannjjm 3335 4 used use VBN cord-023095-4dannjjm 3335 5 to to TO cord-023095-4dannjjm 3335 6 stop stop VB cord-023095-4dannjjm 3335 7 progressive progressive JJ cord-023095-4dannjjm 3335 8 inflammation inflammation NN cord-023095-4dannjjm 3335 9 and and CC cord-023095-4dannjjm 3335 10 fibrosis fibrosis NN cord-023095-4dannjjm 3335 11 but but CC cord-023095-4dannjjm 3335 12 are be VBP cord-023095-4dannjjm 3335 13 associated associate VBN cord-023095-4dannjjm 3335 14 with with IN cord-023095-4dannjjm 3335 15 significant significant JJ cord-023095-4dannjjm 3335 16 side side NN cord-023095-4dannjjm 3335 17 effects effect NNS cord-023095-4dannjjm 3335 18 including include VBG cord-023095-4dannjjm 3335 19 a a DT cord-023095-4dannjjm 3335 20 steroid steroid JJ cord-023095-4dannjjm 3335 21 hepatopathy hepatopathy NN cord-023095-4dannjjm 3335 22 that that WDT cord-023095-4dannjjm 3335 23 complicates complicate VBZ cord-023095-4dannjjm 3335 24 enzyme enzyme NN cord-023095-4dannjjm 3335 25 monitoring monitoring NN cord-023095-4dannjjm 3335 26 . . . cord-023095-4dannjjm 3336 1 Cyclosporine cyclosporine NN cord-023095-4dannjjm 3336 2 is be VBZ cord-023095-4dannjjm 3336 3 proposed propose VBN cord-023095-4dannjjm 3336 4 as as IN cord-023095-4dannjjm 3336 5 an an DT cord-023095-4dannjjm 3336 6 alternative alternative JJ cord-023095-4dannjjm 3336 7 therapy therapy NN cord-023095-4dannjjm 3336 8 , , , cord-023095-4dannjjm 3336 9 but but CC cord-023095-4dannjjm 3336 10 there there EX cord-023095-4dannjjm 3336 11 are be VBP cord-023095-4dannjjm 3336 12 no no DT cord-023095-4dannjjm 3336 13 published publish VBN cord-023095-4dannjjm 3336 14 reports report NNS cord-023095-4dannjjm 3336 15 of of IN cord-023095-4dannjjm 3336 16 its -PRON- PRP$ cord-023095-4dannjjm 3336 17 use use NN cord-023095-4dannjjm 3336 18 for for IN cord-023095-4dannjjm 3336 19 canine canine JJ cord-023095-4dannjjm 3336 20 CH ch NN cord-023095-4dannjjm 3336 21 . . . cord-023095-4dannjjm 3337 1 Patient patient JJ cord-023095-4dannjjm 3337 2 records record NNS cord-023095-4dannjjm 3337 3 at at IN cord-023095-4dannjjm 3337 4 the the DT cord-023095-4dannjjm 3337 5 CSU CSU NNP cord-023095-4dannjjm 3337 6 Veterinary Veterinary NNP cord-023095-4dannjjm 3337 7 Teaching Teaching NNP cord-023095-4dannjjm 3337 8 Hospital Hospital NNP cord-023095-4dannjjm 3337 9 were be VBD cord-023095-4dannjjm 3337 10 searched search VBN cord-023095-4dannjjm 3337 11 for for IN cord-023095-4dannjjm 3337 12 histologically histologically RB cord-023095-4dannjjm 3337 13 confirmed confirm VBN cord-023095-4dannjjm 3337 14 cases case NNS cord-023095-4dannjjm 3337 15 of of IN cord-023095-4dannjjm 3337 16 CH CH NNP cord-023095-4dannjjm 3337 17 treated treat VBN cord-023095-4dannjjm 3337 18 with with IN cord-023095-4dannjjm 3337 19 cyclosporine cyclosporine NN cord-023095-4dannjjm 3337 20 . . . cord-023095-4dannjjm 3338 1 Data datum NNS cord-023095-4dannjjm 3338 2 were be VBD cord-023095-4dannjjm 3338 3 compiled compile VBN cord-023095-4dannjjm 3338 4 on on IN cord-023095-4dannjjm 3338 5 cyclosporine cyclosporine JJ cord-023095-4dannjjm 3338 6 dosing dosing NN cord-023095-4dannjjm 3338 7 , , , cord-023095-4dannjjm 3338 8 concurrent concurrent JJ cord-023095-4dannjjm 3338 9 medications medication NNS cord-023095-4dannjjm 3338 10 , , , cord-023095-4dannjjm 3338 11 clinical clinical JJ cord-023095-4dannjjm 3338 12 course course NN cord-023095-4dannjjm 3338 13 and and CC cord-023095-4dannjjm 3338 14 biochemical biochemical JJ cord-023095-4dannjjm 3338 15 parameters parameter NNS cord-023095-4dannjjm 3338 16 . . . cord-023095-4dannjjm 3339 1 13 13 CD cord-023095-4dannjjm 3339 2 patients patient NNS cord-023095-4dannjjm 3339 3 over over IN cord-023095-4dannjjm 3339 4 a a DT cord-023095-4dannjjm 3339 5 50-month 50-month CD cord-023095-4dannjjm 3339 6 period period NN cord-023095-4dannjjm 3339 7 were be VBD cord-023095-4dannjjm 3339 8 identified identify VBN cord-023095-4dannjjm 3339 9 . . . cord-023095-4dannjjm 3340 1 Serum serum NN cord-023095-4dannjjm 3340 2 alanine alanine NN cord-023095-4dannjjm 3340 3 aminotransferase aminotransferase NN cord-023095-4dannjjm 3340 4 ( ( -LRB- cord-023095-4dannjjm 3340 5 ALT ALT NNP cord-023095-4dannjjm 3340 6 ) ) -RRB- cord-023095-4dannjjm 3340 7 decreased decrease VBD cord-023095-4dannjjm 3340 8 by by IN cord-023095-4dannjjm 3340 9 an an DT cord-023095-4dannjjm 3340 10 average average NN cord-023095-4dannjjm 3340 11 of of IN cord-023095-4dannjjm 3340 12 71 71 CD cord-023095-4dannjjm 3340 13 % % NN cord-023095-4dannjjm 3340 14 in in IN cord-023095-4dannjjm 3340 15 12 12 CD cord-023095-4dannjjm 3340 16 dogs dog NNS cord-023095-4dannjjm 3340 17 . . . cord-023095-4dannjjm 3341 1 The the DT cord-023095-4dannjjm 3341 2 ALT alt NN cord-023095-4dannjjm 3341 3 normalized normalize VBN cord-023095-4dannjjm 3341 4 completely completely RB cord-023095-4dannjjm 3341 5 in in IN cord-023095-4dannjjm 3341 6 6 6 CD cord-023095-4dannjjm 3341 7 of of IN cord-023095-4dannjjm 3341 8 10 10 CD cord-023095-4dannjjm 3341 9 dogs dog NNS cord-023095-4dannjjm 3341 10 treated treat VBN cord-023095-4dannjjm 3341 11 for for IN cord-023095-4dannjjm 3341 12 4 4 CD cord-023095-4dannjjm 3341 13 60 60 CD cord-023095-4dannjjm 3341 14 days day NNS cord-023095-4dannjjm 3341 15 . . . cord-023095-4dannjjm 3342 1 In in IN cord-023095-4dannjjm 3342 2 5 5 CD cord-023095-4dannjjm 3342 3 of of IN cord-023095-4dannjjm 3342 4 6 6 CD cord-023095-4dannjjm 3342 5 dogs dog NNS cord-023095-4dannjjm 3342 6 on on IN cord-023095-4dannjjm 3342 7 4 4 CD cord-023095-4dannjjm 3342 8 9 9 CD cord-023095-4dannjjm 3343 1 mg mg NNP cord-023095-4dannjjm 3343 2 / / SYM cord-023095-4dannjjm 3343 3 kg kg NNP cord-023095-4dannjjm 3343 4 / / SYM cord-023095-4dannjjm 3343 5 day day NN cord-023095-4dannjjm 3343 6 , , , cord-023095-4dannjjm 3343 7 the the DT cord-023095-4dannjjm 3343 8 ALT ALT NNP cord-023095-4dannjjm 3343 9 also also RB cord-023095-4dannjjm 3343 10 normalized normalize VBD cord-023095-4dannjjm 3343 11 . . . cord-023095-4dannjjm 3344 1 Five five CD cord-023095-4dannjjm 3344 2 of of IN cord-023095-4dannjjm 3344 3 the the DT cord-023095-4dannjjm 3344 4 6 6 CD cord-023095-4dannjjm 3344 5 patients patient NNS cord-023095-4dannjjm 3344 6 that that WDT cord-023095-4dannjjm 3344 7 exhibited exhibit VBD cord-023095-4dannjjm 3344 8 clinical clinical JJ cord-023095-4dannjjm 3344 9 signs sign NNS cord-023095-4dannjjm 3344 10 prior prior RB cord-023095-4dannjjm 3344 11 to to IN cord-023095-4dannjjm 3344 12 treatment treatment NN cord-023095-4dannjjm 3344 13 showed show VBD cord-023095-4dannjjm 3344 14 measurable measurable JJ cord-023095-4dannjjm 3344 15 improvement improvement NN cord-023095-4dannjjm 3344 16 ( ( -LRB- cord-023095-4dannjjm 3344 17 weight weight NN cord-023095-4dannjjm 3344 18 gain gain NN cord-023095-4dannjjm 3344 19 , , , cord-023095-4dannjjm 3344 20 fewer few JJR cord-023095-4dannjjm 3344 21 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 3344 22 signs sign NNS cord-023095-4dannjjm 3344 23 ) ) -RRB- cord-023095-4dannjjm 3344 24 . . . cord-023095-4dannjjm 3345 1 Eight eight CD cord-023095-4dannjjm 3345 2 patients patient NNS cord-023095-4dannjjm 3345 3 had have VBD cord-023095-4dannjjm 3345 4 hyperbilirubinemia hyperbilirubinemia NN cord-023095-4dannjjm 3345 5 or or CC cord-023095-4dannjjm 3345 6 ascites ascites NN cord-023095-4dannjjm 3345 7 prior prior RB cord-023095-4dannjjm 3345 8 to to IN cord-023095-4dannjjm 3345 9 treatment treatment NN cord-023095-4dannjjm 3345 10 ; ; : cord-023095-4dannjjm 3345 11 these these DT cord-023095-4dannjjm 3345 12 resolved resolve VBD cord-023095-4dannjjm 3345 13 in in IN cord-023095-4dannjjm 3345 14 7 7 CD cord-023095-4dannjjm 3345 15 . . . cord-023095-4dannjjm 3346 1 Post post JJ cord-023095-4dannjjm 3346 2 - - JJ cord-023095-4dannjjm 3346 3 treatment treatment JJ cord-023095-4dannjjm 3346 4 histopathology histopathology NN cord-023095-4dannjjm 3346 5 , , , cord-023095-4dannjjm 3346 6 available available JJ cord-023095-4dannjjm 3346 7 in in IN cord-023095-4dannjjm 3346 8 one one CD cord-023095-4dannjjm 3346 9 patient patient NN cord-023095-4dannjjm 3346 10 , , , cord-023095-4dannjjm 3346 11 revealed reveal VBD cord-023095-4dannjjm 3346 12 decreased decreased JJ cord-023095-4dannjjm 3346 13 severity severity NN cord-023095-4dannjjm 3346 14 of of IN cord-023095-4dannjjm 3346 15 CH CH NNP cord-023095-4dannjjm 3346 16 . . . cord-023095-4dannjjm 3347 1 Five five CD cord-023095-4dannjjm 3347 2 patients patient NNS cord-023095-4dannjjm 3347 3 exhibited exhibit VBD cord-023095-4dannjjm 3347 4 adverse adverse JJ cord-023095-4dannjjm 3347 5 effects effect NNS cord-023095-4dannjjm 3347 6 including include VBG cord-023095-4dannjjm 3347 7 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 3347 8 signs sign NNS cord-023095-4dannjjm 3347 9 ( ( -LRB- cord-023095-4dannjjm 3347 10 3 3 CD cord-023095-4dannjjm 3347 11 ) ) -RRB- cord-023095-4dannjjm 3347 12 , , , cord-023095-4dannjjm 3347 13 gingival gingival JJ cord-023095-4dannjjm 3347 14 hyperplasia hyperplasia NN cord-023095-4dannjjm 3347 15 ( ( -LRB- cord-023095-4dannjjm 3347 16 1 1 CD cord-023095-4dannjjm 3347 17 ) ) -RRB- cord-023095-4dannjjm 3347 18 , , , cord-023095-4dannjjm 3347 19 and and CC cord-023095-4dannjjm 3347 20 papillomatosis papillomatosis NNP cord-023095-4dannjjm 3347 21 ( ( -LRB- cord-023095-4dannjjm 3347 22 1 1 CD cord-023095-4dannjjm 3347 23 ) ) -RRB- cord-023095-4dannjjm 3347 24 . . . cord-023095-4dannjjm 3348 1 Cyclosporine cyclosporine NN cord-023095-4dannjjm 3348 2 was be VBD cord-023095-4dannjjm 3348 3 discontinued discontinue VBN cord-023095-4dannjjm 3348 4 in in IN cord-023095-4dannjjm 3348 5 2 2 CD cord-023095-4dannjjm 3348 6 dogs dog NNS cord-023095-4dannjjm 3348 7 with with IN cord-023095-4dannjjm 3348 8 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 3348 9 signs sign NNS cord-023095-4dannjjm 3348 10 . . . cord-023095-4dannjjm 3349 1 Cyclosporine cyclosporine NN cord-023095-4dannjjm 3349 2 was be VBD cord-023095-4dannjjm 3349 3 an an DT cord-023095-4dannjjm 3349 4 effective effective JJ cord-023095-4dannjjm 3349 5 therapy therapy NN cord-023095-4dannjjm 3349 6 for for IN cord-023095-4dannjjm 3349 7 many many JJ cord-023095-4dannjjm 3349 8 cases case NNS cord-023095-4dannjjm 3349 9 of of IN cord-023095-4dannjjm 3349 10 CH CH NNP cord-023095-4dannjjm 3349 11 and and CC cord-023095-4dannjjm 3349 12 should should MD cord-023095-4dannjjm 3349 13 be be VB cord-023095-4dannjjm 3349 14 considered consider VBN cord-023095-4dannjjm 3349 15 for for IN cord-023095-4dannjjm 3349 16 patients patient NNS cord-023095-4dannjjm 3349 17 who who WP cord-023095-4dannjjm 3349 18 are be VBP cord-023095-4dannjjm 3349 19 refractory refractory JJ cord-023095-4dannjjm 3349 20 to to IN cord-023095-4dannjjm 3349 21 or or CC cord-023095-4dannjjm 3349 22 can can MD cord-023095-4dannjjm 3349 23 not not RB cord-023095-4dannjjm 3349 24 tolerate tolerate VB cord-023095-4dannjjm 3349 25 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 3349 26 . . . cord-023095-4dannjjm 3350 1 Prospective prospective JJ cord-023095-4dannjjm 3350 2 clinical clinical JJ cord-023095-4dannjjm 3350 3 trials trial NNS cord-023095-4dannjjm 3350 4 with with IN cord-023095-4dannjjm 3350 5 histological histological JJ cord-023095-4dannjjm 3350 6 documentation documentation NN cord-023095-4dannjjm 3350 7 are be VBP cord-023095-4dannjjm 3350 8 needed need VBN cord-023095-4dannjjm 3350 9 to to TO cord-023095-4dannjjm 3350 10 better well RBR cord-023095-4dannjjm 3350 11 define define VB cord-023095-4dannjjm 3350 12 cyclosporine cyclosporine NN cord-023095-4dannjjm 3350 13 's 's POS cord-023095-4dannjjm 3350 14 effectiveness effectiveness NN cord-023095-4dannjjm 3350 15 in in IN cord-023095-4dannjjm 3350 16 CH CH NNP cord-023095-4dannjjm 3350 17 . . . cord-023095-4dannjjm 3351 1 Insertion insertion NN cord-023095-4dannjjm 3351 2 of of IN cord-023095-4dannjjm 3351 3 the the DT cord-023095-4dannjjm 3351 4 Veress Veress NNP cord-023095-4dannjjm 3351 5 needle needle NN cord-023095-4dannjjm 3351 6 and and CC cord-023095-4dannjjm 3351 7 establishment establishment NN cord-023095-4dannjjm 3351 8 of of IN cord-023095-4dannjjm 3351 9 pneumoperitoneum pneumoperitoneum NNP cord-023095-4dannjjm 3351 10 is be VBZ cord-023095-4dannjjm 3351 11 associated associate VBN cord-023095-4dannjjm 3351 12 with with IN cord-023095-4dannjjm 3351 13 22 22 CD cord-023095-4dannjjm 3351 14 to to TO cord-023095-4dannjjm 3351 15 57 57 CD cord-023095-4dannjjm 3351 16 % % NN cord-023095-4dannjjm 3351 17 of of IN cord-023095-4dannjjm 3351 18 all all DT cord-023095-4dannjjm 3351 19 laparoscopic laparoscopic JJ cord-023095-4dannjjm 3351 20 complications complication NNS cord-023095-4dannjjm 3351 21 in in IN cord-023095-4dannjjm 3351 22 humans human NNS cord-023095-4dannjjm 3351 23 . . . cord-023095-4dannjjm 3352 1 The the DT cord-023095-4dannjjm 3352 2 purpose purpose NN cord-023095-4dannjjm 3352 3 of of IN cord-023095-4dannjjm 3352 4 this this DT cord-023095-4dannjjm 3352 5 study study NN cord-023095-4dannjjm 3352 6 was be VBD cord-023095-4dannjjm 3352 7 to to TO cord-023095-4dannjjm 3352 8 determine determine VB cord-023095-4dannjjm 3352 9 the the DT cord-023095-4dannjjm 3352 10 accuracy accuracy NN cord-023095-4dannjjm 3352 11 of of IN cord-023095-4dannjjm 3352 12 interpretation interpretation NN cord-023095-4dannjjm 3352 13 of of IN cord-023095-4dannjjm 3352 14 tissue tissue NN cord-023095-4dannjjm 3352 15 impedance impedance NN cord-023095-4dannjjm 3352 16 measurements measurement NNS cord-023095-4dannjjm 3352 17 for for IN cord-023095-4dannjjm 3352 18 Veress Veress NNP cord-023095-4dannjjm 3352 19 needle needle NN cord-023095-4dannjjm 3352 20 location location NN cord-023095-4dannjjm 3352 21 . . . cord-023095-4dannjjm 3353 1 Two two CD cord-023095-4dannjjm 3353 2 laparoscopists laparoscopist NNS cord-023095-4dannjjm 3353 3 , , , cord-023095-4dannjjm 3353 4 blinded blind VBN cord-023095-4dannjjm 3353 5 to to TO cord-023095-4dannjjm 3353 6 impedance impedance VB cord-023095-4dannjjm 3353 7 measurements measurement NNS cord-023095-4dannjjm 3353 8 , , , cord-023095-4dannjjm 3353 9 placed place VBD cord-023095-4dannjjm 3353 10 reusable reusable JJ cord-023095-4dannjjm 3353 11 Veress Veress NNP cord-023095-4dannjjm 3353 12 needles needle NNS cord-023095-4dannjjm 3353 13 in in IN cord-023095-4dannjjm 3353 14 20 20 CD cord-023095-4dannjjm 3353 15 cadaverous cadaverous JJ cord-023095-4dannjjm 3353 16 dogs dog NNS cord-023095-4dannjjm 3353 17 euthanized euthanize VBN cord-023095-4dannjjm 3353 18 for for IN cord-023095-4dannjjm 3353 19 reasons reason NNS cord-023095-4dannjjm 3353 20 unrelated unrelated JJ cord-023095-4dannjjm 3353 21 to to IN cord-023095-4dannjjm 3353 22 the the DT cord-023095-4dannjjm 3353 23 study study NN cord-023095-4dannjjm 3353 24 . . . cord-023095-4dannjjm 3354 1 Placement placement NN cord-023095-4dannjjm 3354 2 order order NN cord-023095-4dannjjm 3354 3 was be VBD cord-023095-4dannjjm 3354 4 randomized randomized JJ cord-023095-4dannjjm 3354 5 . . . cord-023095-4dannjjm 3355 1 A a DT cord-023095-4dannjjm 3355 2 third third JJ cord-023095-4dannjjm 3355 3 individual individual NN cord-023095-4dannjjm 3355 4 evaluated evaluate VBD cord-023095-4dannjjm 3355 5 impedance impedance NN cord-023095-4dannjjm 3355 6 measurements measurement NNS cord-023095-4dannjjm 3355 7 using use VBG cord-023095-4dannjjm 3355 8 a a DT cord-023095-4dannjjm 3355 9 handheld handheld JJ cord-023095-4dannjjm 3355 10 device device NN cord-023095-4dannjjm 3355 11 ( ( -LRB- cord-023095-4dannjjm 3355 12 SensorMed SensorMed NNP cord-023095-4dannjjm 3355 13 , , , cord-023095-4dannjjm 3355 14 Knoxville Knoxville NNP cord-023095-4dannjjm 3355 15 TN TN NNP cord-023095-4dannjjm 3355 16 ) ) -RRB- cord-023095-4dannjjm 3355 17 to to TO cord-023095-4dannjjm 3355 18 determine determine VB cord-023095-4dannjjm 3355 19 correct correct JJ cord-023095-4dannjjm 3355 20 versus versus IN cord-023095-4dannjjm 3355 21 incorrect incorrect JJ cord-023095-4dannjjm 3355 22 needle needle NN cord-023095-4dannjjm 3355 23 placement placement NN cord-023095-4dannjjm 3355 24 . . . cord-023095-4dannjjm 3356 1 Veress Veress NNP cord-023095-4dannjjm 3356 2 needle needle NN cord-023095-4dannjjm 3356 3 locations location NNS cord-023095-4dannjjm 3356 4 were be VBD cord-023095-4dannjjm 3356 5 marked mark VBN cord-023095-4dannjjm 3356 6 using use VBG cord-023095-4dannjjm 3356 7 contrasting contrast VBG cord-023095-4dannjjm 3356 8 colors color NNS cord-023095-4dannjjm 3356 9 of of IN cord-023095-4dannjjm 3356 10 India India NNP cord-023095-4dannjjm 3356 11 Ink Ink NNP cord-023095-4dannjjm 3356 12 ; ; : cord-023095-4dannjjm 3356 13 tissues tissue NNS cord-023095-4dannjjm 3356 14 were be VBD cord-023095-4dannjjm 3356 15 dissected dissect VBN cord-023095-4dannjjm 3356 16 to to TO cord-023095-4dannjjm 3356 17 determine determine VB cord-023095-4dannjjm 3356 18 ink ink NN cord-023095-4dannjjm 3356 19 locations location NNS cord-023095-4dannjjm 3356 20 . . . cord-023095-4dannjjm 3357 1 Impedance impedance NN cord-023095-4dannjjm 3357 2 measurement measurement NN cord-023095-4dannjjm 3357 3 interpretation interpretation NN cord-023095-4dannjjm 3357 4 identified identify VBD cord-023095-4dannjjm 3357 5 29/33 29/33 CD cord-023095-4dannjjm 3357 6 correct correct NN cord-023095-4dannjjm 3357 7 and and CC cord-023095-4dannjjm 3357 8 7/ 7/ CD cord-023095-4dannjjm 3357 9 7 7 CD cord-023095-4dannjjm 3357 10 incorrect incorrect JJ cord-023095-4dannjjm 3357 11 placements placement NNS cord-023095-4dannjjm 3357 12 , , , cord-023095-4dannjjm 3357 13 respectively respectively RB cord-023095-4dannjjm 3357 14 . . . cord-023095-4dannjjm 3358 1 Sensitivity sensitivity NN cord-023095-4dannjjm 3358 2 , , , cord-023095-4dannjjm 3358 3 specificity specificity NN cord-023095-4dannjjm 3358 4 , , , cord-023095-4dannjjm 3358 5 accuracy accuracy NN cord-023095-4dannjjm 3358 6 , , , cord-023095-4dannjjm 3358 7 and and CC cord-023095-4dannjjm 3358 8 precision precision NN cord-023095-4dannjjm 3358 9 for for IN cord-023095-4dannjjm 3358 10 correct correct JJ cord-023095-4dannjjm 3358 11 Veress Veress NNP cord-023095-4dannjjm 3358 12 needle needle NN cord-023095-4dannjjm 3358 13 placement placement NN cord-023095-4dannjjm 3358 14 are be VBP cord-023095-4dannjjm 3358 15 listed list VBN cord-023095-4dannjjm 3358 16 below below RB cord-023095-4dannjjm 3358 17 . . . cord-023095-4dannjjm 3359 1 Agreement agreement NN cord-023095-4dannjjm 3359 2 was be VBD cord-023095-4dannjjm 3359 3 moderate moderate JJ cord-023095-4dannjjm 3359 4 ( ( -LRB- cord-023095-4dannjjm 3359 5 Kappa Kappa NNP cord-023095-4dannjjm 3359 6 0.50 0.50 CD cord-023095-4dannjjm 3359 7 , , , cord-023095-4dannjjm 3359 8 p p NN cord-023095-4dannjjm 3359 9 5 5 CD cord-023095-4dannjjm 3359 10 0.01 0.01 CD cord-023095-4dannjjm 3359 11 ) ) -RRB- cord-023095-4dannjjm 3359 12 for for IN cord-023095-4dannjjm 3359 13 placements placement NNS cord-023095-4dannjjm 3359 14 by by IN cord-023095-4dannjjm 3359 15 Operator Operator NNP cord-023095-4dannjjm 3359 16 1 1 CD cord-023095-4dannjjm 3359 17 and and CC cord-023095-4dannjjm 3359 18 very very RB cord-023095-4dannjjm 3359 19 high high JJ cord-023095-4dannjjm 3360 1 ( ( -LRB- cord-023095-4dannjjm 3360 2 Kappa Kappa NNP cord-023095-4dannjjm 3360 3 5 5 CD cord-023095-4dannjjm 3360 4 0.88 0.88 CD cord-023095-4dannjjm 3360 5 , , , cord-023095-4dannjjm 3360 6 p p NN cord-023095-4dannjjm 3360 7 o o NN cord-023095-4dannjjm 3360 8 0.01 0.01 CD cord-023095-4dannjjm 3360 9 ) ) -RRB- cord-023095-4dannjjm 3360 10 for for IN cord-023095-4dannjjm 3360 11 placements placement NNS cord-023095-4dannjjm 3360 12 by by IN cord-023095-4dannjjm 3360 13 Operator Operator NNP cord-023095-4dannjjm 3360 14 2 2 CD cord-023095-4dannjjm 3360 15 . . . cord-023095-4dannjjm 3361 1 Results result NNS cord-023095-4dannjjm 3361 2 for for IN cord-023095-4dannjjm 3361 3 tissue tissue NN cord-023095-4dannjjm 3361 4 impedance impedance NN cord-023095-4dannjjm 3361 5 measurement measurement NN cord-023095-4dannjjm 3361 6 interpretation interpretation NN cord-023095-4dannjjm 3361 7 are be VBP cord-023095-4dannjjm 3361 8 superior superior JJ cord-023095-4dannjjm 3361 9 to to IN cord-023095-4dannjjm 3361 10 published publish VBN cord-023095-4dannjjm 3361 11 data datum NNS cord-023095-4dannjjm 3361 12 for for IN cord-023095-4dannjjm 3361 13 currently currently RB cord-023095-4dannjjm 3361 14 available available JJ cord-023095-4dannjjm 3361 15 tests test NNS cord-023095-4dannjjm 3361 16 . . . cord-023095-4dannjjm 3362 1 Impedance impedance NN cord-023095-4dannjjm 3362 2 measurements measurement NNS cord-023095-4dannjjm 3362 3 accurately accurately RB cord-023095-4dannjjm 3362 4 detected detect VBD cord-023095-4dannjjm 3362 5 all all DT cord-023095-4dannjjm 3362 6 incorrect incorrect JJ cord-023095-4dannjjm 3362 7 needle needle NN cord-023095-4dannjjm 3362 8 placements placement NNS cord-023095-4dannjjm 3362 9 . . . cord-023095-4dannjjm 3363 1 Comparison comparison NN cord-023095-4dannjjm 3363 2 of of IN cord-023095-4dannjjm 3363 3 needle needle NN cord-023095-4dannjjm 3363 4 placement placement NN cord-023095-4dannjjm 3363 5 with with IN cord-023095-4dannjjm 3363 6 and and CC cord-023095-4dannjjm 3363 7 without without IN cord-023095-4dannjjm 3363 8 tissue tissue NN cord-023095-4dannjjm 3363 9 impedance impedance NN cord-023095-4dannjjm 3363 10 feedback feedback NN cord-023095-4dannjjm 3363 11 will will MD cord-023095-4dannjjm 3363 12 be be VB cord-023095-4dannjjm 3363 13 necessary necessary JJ cord-023095-4dannjjm 3363 14 to to TO cord-023095-4dannjjm 3363 15 determine determine VB cord-023095-4dannjjm 3363 16 whether whether IN cord-023095-4dannjjm 3363 17 it -PRON- PRP cord-023095-4dannjjm 3363 18 increases increase VBZ cord-023095-4dannjjm 3363 19 operator operator NN cord-023095-4dannjjm 3363 20 detection detection NN cord-023095-4dannjjm 3363 21 of of IN cord-023095-4dannjjm 3363 22 inappropriate inappropriate JJ cord-023095-4dannjjm 3363 23 Veress Veress NNP cord-023095-4dannjjm 3363 24 needle needle NN cord-023095-4dannjjm 3363 25 placement placement NN cord-023095-4dannjjm 3363 26 and and CC cord-023095-4dannjjm 3363 27 decreases decrease VBZ cord-023095-4dannjjm 3363 28 installment installment NN cord-023095-4dannjjm 3363 29 phase phase NN cord-023095-4dannjjm 3363 30 complication complication NN cord-023095-4dannjjm 3363 31 rates rate NNS cord-023095-4dannjjm 3363 32 . . . cord-023095-4dannjjm 3364 1 Delayed delay VBN cord-023095-4dannjjm 3364 2 detection detection NN cord-023095-4dannjjm 3364 3 of of IN cord-023095-4dannjjm 3364 4 intestinal intestinal JJ cord-023095-4dannjjm 3364 5 perforation perforation NN cord-023095-4dannjjm 3364 6 during during IN cord-023095-4dannjjm 3364 7 Veress Veress NNP cord-023095-4dannjjm 3364 8 needle needle NN cord-023095-4dannjjm 3364 9 insertion insertion NN cord-023095-4dannjjm 3364 10 is be VBZ cord-023095-4dannjjm 3364 11 associated associate VBN cord-023095-4dannjjm 3364 12 with with IN cord-023095-4dannjjm 3364 13 high high JJ cord-023095-4dannjjm 3364 14 mortality mortality NN cord-023095-4dannjjm 3364 15 . . . cord-023095-4dannjjm 3365 1 The the DT cord-023095-4dannjjm 3365 2 purpose purpose NN cord-023095-4dannjjm 3365 3 of of IN cord-023095-4dannjjm 3365 4 this this DT cord-023095-4dannjjm 3365 5 study study NN cord-023095-4dannjjm 3365 6 was be VBD cord-023095-4dannjjm 3365 7 to to TO cord-023095-4dannjjm 3365 8 evaluate evaluate VB cord-023095-4dannjjm 3365 9 the the DT cord-023095-4dannjjm 3365 10 accuracy accuracy NN cord-023095-4dannjjm 3365 11 of of IN cord-023095-4dannjjm 3365 12 tissue tissue NN cord-023095-4dannjjm 3365 13 impedance impedance NN cord-023095-4dannjjm 3365 14 measurement measurement NN cord-023095-4dannjjm 3365 15 interpretation interpretation NN cord-023095-4dannjjm 3365 16 for for IN cord-023095-4dannjjm 3365 17 Veress Veress NNP cord-023095-4dannjjm 3365 18 needle needle NN cord-023095-4dannjjm 3365 19 location location NN cord-023095-4dannjjm 3365 20 . . . cord-023095-4dannjjm 3366 1 Two two CD cord-023095-4dannjjm 3366 2 laparoscopists laparoscopist NNS cord-023095-4dannjjm 3366 3 , , , cord-023095-4dannjjm 3366 4 blinded blind VBN cord-023095-4dannjjm 3366 5 to to TO cord-023095-4dannjjm 3366 6 impedance impedance VB cord-023095-4dannjjm 3366 7 measurements measurement NNS cord-023095-4dannjjm 3366 8 , , , cord-023095-4dannjjm 3366 9 placed place VBD cord-023095-4dannjjm 3366 10 reusable reusable JJ cord-023095-4dannjjm 3366 11 Veress Veress NNP cord-023095-4dannjjm 3366 12 needles needle NNS cord-023095-4dannjjm 3366 13 in in IN cord-023095-4dannjjm 3366 14 24 24 CD cord-023095-4dannjjm 3366 15 cadaverous cadaverous JJ cord-023095-4dannjjm 3366 16 cats cat NNS cord-023095-4dannjjm 3366 17 . . . cord-023095-4dannjjm 3367 1 Placement placement NN cord-023095-4dannjjm 3367 2 order order NN cord-023095-4dannjjm 3367 3 was be VBD cord-023095-4dannjjm 3367 4 randomized randomized JJ cord-023095-4dannjjm 3367 5 . . . cord-023095-4dannjjm 3368 1 A a DT cord-023095-4dannjjm 3368 2 third third JJ cord-023095-4dannjjm 3368 3 individual individual NN cord-023095-4dannjjm 3368 4 evaluated evaluate VBD cord-023095-4dannjjm 3368 5 impedance impedance NN cord-023095-4dannjjm 3368 6 measurements measurement NNS cord-023095-4dannjjm 3368 7 ( ( -LRB- cord-023095-4dannjjm 3368 8 SensorMed SensorMed NNP cord-023095-4dannjjm 3368 9 , , , cord-023095-4dannjjm 3368 10 Knoxville Knoxville NNP cord-023095-4dannjjm 3368 11 , , , cord-023095-4dannjjm 3368 12 TN TN NNP cord-023095-4dannjjm 3368 13 ) ) -RRB- cord-023095-4dannjjm 3368 14 to to TO cord-023095-4dannjjm 3368 15 determine determine VB cord-023095-4dannjjm 3368 16 placement placement NN cord-023095-4dannjjm 3368 17 location location NN cord-023095-4dannjjm 3368 18 . . . cord-023095-4dannjjm 3369 1 Needle needle NN cord-023095-4dannjjm 3369 2 locations location NNS cord-023095-4dannjjm 3369 3 were be VBD cord-023095-4dannjjm 3369 4 marked mark VBN cord-023095-4dannjjm 3369 5 using use VBG cord-023095-4dannjjm 3369 6 India India NNP cord-023095-4dannjjm 3369 7 Ink ink NN cord-023095-4dannjjm 3369 8 ; ; : cord-023095-4dannjjm 3369 9 tissues tissue NNS cord-023095-4dannjjm 3369 10 were be VBD cord-023095-4dannjjm 3369 11 dissected dissect VBN cord-023095-4dannjjm 3369 12 to to TO cord-023095-4dannjjm 3369 13 determine determine VB cord-023095-4dannjjm 3369 14 ink ink NN cord-023095-4dannjjm 3369 15 locations location NNS cord-023095-4dannjjm 3369 16 . . . cord-023095-4dannjjm 3370 1 Impedance impedance NN cord-023095-4dannjjm 3370 2 measurement measurement NN cord-023095-4dannjjm 3370 3 interpretation interpretation NN cord-023095-4dannjjm 3370 4 identified identify VBD cord-023095-4dannjjm 3370 5 36/38 36/38 CD cord-023095-4dannjjm 3370 6 correct correct JJ cord-023095-4dannjjm 3370 7 and and CC cord-023095-4dannjjm 3370 8 2/10 2/10 CD cord-023095-4dannjjm 3370 9 incorrect incorrect JJ cord-023095-4dannjjm 3370 10 placements placement NNS cord-023095-4dannjjm 3370 11 . . . cord-023095-4dannjjm 3371 1 All all DT cord-023095-4dannjjm 3371 2 8 8 CD cord-023095-4dannjjm 3371 3 undetected undetected JJ cord-023095-4dannjjm 3371 4 incorrect incorrect JJ cord-023095-4dannjjm 3371 5 placements placement NNS cord-023095-4dannjjm 3371 6 were be VBD cord-023095-4dannjjm 3371 7 located locate VBN cord-023095-4dannjjm 3371 8 within within IN cord-023095-4dannjjm 3371 9 the the DT cord-023095-4dannjjm 3371 10 retroperitoneal retroperitoneal JJ cord-023095-4dannjjm 3371 11 fat fat JJ cord-023095-4dannjjm 3371 12 pad pad NN cord-023095-4dannjjm 3371 13 . . . cord-023095-4dannjjm 3372 1 Sensitivity sensitivity NN cord-023095-4dannjjm 3372 2 , , , cord-023095-4dannjjm 3372 3 specificity specificity NN cord-023095-4dannjjm 3372 4 , , , cord-023095-4dannjjm 3372 5 accuracy accuracy NN cord-023095-4dannjjm 3372 6 , , , cord-023095-4dannjjm 3372 7 and and CC cord-023095-4dannjjm 3372 8 precision precision NN cord-023095-4dannjjm 3372 9 for for IN cord-023095-4dannjjm 3372 10 correct correct JJ cord-023095-4dannjjm 3372 11 Veress Veress NNP cord-023095-4dannjjm 3372 12 needle needle NN cord-023095-4dannjjm 3372 13 placement placement NN cord-023095-4dannjjm 3372 14 are be VBP cord-023095-4dannjjm 3372 15 listed list VBN cord-023095-4dannjjm 3372 16 below below RB cord-023095-4dannjjm 3372 17 . . . cord-023095-4dannjjm 3373 1 Correlation correlation NN cord-023095-4dannjjm 3373 2 was be VBD cord-023095-4dannjjm 3373 3 absent absent JJ cord-023095-4dannjjm 3373 4 ( ( -LRB- cord-023095-4dannjjm 3373 5 Kappa Kappa NNP cord-023095-4dannjjm 3373 6 À0.15 À0.15 NNP cord-023095-4dannjjm 3373 7 , , , cord-023095-4dannjjm 3373 8 p p NN cord-023095-4dannjjm 3373 9 5 5 CD cord-023095-4dannjjm 3373 10 0.34 0.34 CD cord-023095-4dannjjm 3373 11 ) ) -RRB- cord-023095-4dannjjm 3373 12 for for IN cord-023095-4dannjjm 3373 13 placements placement NNS cord-023095-4dannjjm 3373 14 by by IN cord-023095-4dannjjm 3373 15 Operator Operator NNP cord-023095-4dannjjm 3373 16 1 1 CD cord-023095-4dannjjm 3373 17 and and CC cord-023095-4dannjjm 3373 18 substantial substantial JJ cord-023095-4dannjjm 3373 19 ( ( -LRB- cord-023095-4dannjjm 3373 20 Kappa Kappa NNP cord-023095-4dannjjm 3373 21 0.78 0.78 CD cord-023095-4dannjjm 3373 22 , , , cord-023095-4dannjjm 3373 23 p p NN cord-023095-4dannjjm 3373 24 o o NN cord-023095-4dannjjm 3373 25 0.01 0.01 CD cord-023095-4dannjjm 3373 26 ) ) -RRB- cord-023095-4dannjjm 3373 27 for for IN cord-023095-4dannjjm 3373 28 Operator operator NN cord-023095-4dannjjm 3373 29 2 2 CD cord-023095-4dannjjm 3373 30 . . . cord-023095-4dannjjm 3374 1 There there EX cord-023095-4dannjjm 3374 2 was be VBD cord-023095-4dannjjm 3374 3 no no DT cord-023095-4dannjjm 3374 4 association association NN cord-023095-4dannjjm 3374 5 between between IN cord-023095-4dannjjm 3374 6 correct correct JJ cord-023095-4dannjjm 3374 7 or or CC cord-023095-4dannjjm 3374 8 incorrect incorrect JJ cord-023095-4dannjjm 3374 9 placement placement NN cord-023095-4dannjjm 3374 10 and and CC cord-023095-4dannjjm 3374 11 operator operator NN cord-023095-4dannjjm 3374 12 on on IN cord-023095-4dannjjm 3374 13 Chi Chi NNP cord-023095-4dannjjm 3374 14 - - HYPH cord-023095-4dannjjm 3374 15 squared squared JJ cord-023095-4dannjjm 3374 16 analysis analysis NN cord-023095-4dannjjm 3374 17 . . . cord-023095-4dannjjm 3375 1 Failure failure NN cord-023095-4dannjjm 3375 2 of of IN cord-023095-4dannjjm 3375 3 impedance impedance NN cord-023095-4dannjjm 3375 4 measurements measurement NNS cord-023095-4dannjjm 3375 5 to to TO cord-023095-4dannjjm 3375 6 identify identify VB cord-023095-4dannjjm 3375 7 placement placement NN cord-023095-4dannjjm 3375 8 in in IN cord-023095-4dannjjm 3375 9 the the DT cord-023095-4dannjjm 3375 10 retroperitoneal retroperitoneal JJ cord-023095-4dannjjm 3375 11 fat fat JJ cord-023095-4dannjjm 3375 12 pad pad NN cord-023095-4dannjjm 3375 13 resulted result VBN cord-023095-4dannjjm 3375 14 in in IN cord-023095-4dannjjm 3375 15 poor poor JJ cord-023095-4dannjjm 3375 16 accuracy accuracy NN cord-023095-4dannjjm 3375 17 and and CC cord-023095-4dannjjm 3375 18 discordant discordant JJ cord-023095-4dannjjm 3375 19 Kappa Kappa NNP cord-023095-4dannjjm 3375 20 statistics statistic NNS cord-023095-4dannjjm 3375 21 . . . cord-023095-4dannjjm 3376 1 Small small JJ cord-023095-4dannjjm 3376 2 cat cat NN cord-023095-4dannjjm 3376 3 size size NN cord-023095-4dannjjm 3376 4 limited limit VBD cord-023095-4dannjjm 3376 5 the the DT cord-023095-4dannjjm 3376 6 number number NN cord-023095-4dannjjm 3376 7 of of IN cord-023095-4dannjjm 3376 8 appropriate appropriate JJ cord-023095-4dannjjm 3376 9 placement placement NN cord-023095-4dannjjm 3376 10 sites site NNS cord-023095-4dannjjm 3376 11 , , , cord-023095-4dannjjm 3376 12 perhaps perhaps RB cord-023095-4dannjjm 3376 13 resulting result VBG cord-023095-4dannjjm 3376 14 in in IN cord-023095-4dannjjm 3376 15 excessively excessively RB cord-023095-4dannjjm 3376 16 dorsal dorsal JJ cord-023095-4dannjjm 3376 17 placement placement NN cord-023095-4dannjjm 3376 18 . . . cord-023095-4dannjjm 3377 1 Comparison comparison NN cord-023095-4dannjjm 3377 2 of of IN cord-023095-4dannjjm 3377 3 needle needle NN cord-023095-4dannjjm 3377 4 placement placement NN cord-023095-4dannjjm 3377 5 with with IN cord-023095-4dannjjm 3377 6 and and CC cord-023095-4dannjjm 3377 7 without without IN cord-023095-4dannjjm 3377 8 tissue tissue NN cord-023095-4dannjjm 3377 9 impedance impedance NN cord-023095-4dannjjm 3377 10 feedback feedback NN cord-023095-4dannjjm 3377 11 will will MD cord-023095-4dannjjm 3377 12 be be VB cord-023095-4dannjjm 3377 13 necessary necessary JJ cord-023095-4dannjjm 3377 14 to to TO cord-023095-4dannjjm 3377 15 determine determine VB cord-023095-4dannjjm 3377 16 whether whether IN cord-023095-4dannjjm 3377 17 impedance impedance NN cord-023095-4dannjjm 3377 18 measurements measurement NNS cord-023095-4dannjjm 3377 19 increase increase VBP cord-023095-4dannjjm 3377 20 detection detection NN cord-023095-4dannjjm 3377 21 of of IN cord-023095-4dannjjm 3377 22 inappropriate inappropriate JJ cord-023095-4dannjjm 3377 23 Veress Veress NNP cord-023095-4dannjjm 3377 24 needle needle NN cord-023095-4dannjjm 3377 25 placements placement NNS cord-023095-4dannjjm 3377 26 or or CC cord-023095-4dannjjm 3377 27 decrease decrease VB cord-023095-4dannjjm 3377 28 installment installment NN cord-023095-4dannjjm 3377 29 phase phase NN cord-023095-4dannjjm 3377 30 complication complication NN cord-023095-4dannjjm 3377 31 rates rate NNS cord-023095-4dannjjm 3377 32 . . . cord-023095-4dannjjm 3378 1 Best good JJS cord-023095-4dannjjm 3378 2 clinicopathologic clinicopathologic JJ cord-023095-4dannjjm 3378 3 tests test NNS cord-023095-4dannjjm 3378 4 detecting detect VBG cord-023095-4dannjjm 3378 5 portosystemic portosystemic JJ cord-023095-4dannjjm 3378 6 shunting shunting NN cord-023095-4dannjjm 3378 7 ( ( -LRB- cord-023095-4dannjjm 3378 8 PSS PSS NNP cord-023095-4dannjjm 3378 9 ) ) -RRB- cord-023095-4dannjjm 3378 10 in in IN cord-023095-4dannjjm 3378 11 dogs dog NNS cord-023095-4dannjjm 3378 12 remains remain VBZ cord-023095-4dannjjm 3378 13 controversial controversial JJ cord-023095-4dannjjm 3378 14 . . . cord-023095-4dannjjm 3379 1 This this DT cord-023095-4dannjjm 3379 2 retrospective retrospective JJ cord-023095-4dannjjm 3379 3 study study NN cord-023095-4dannjjm 3379 4 examined examine VBD cord-023095-4dannjjm 3379 5 performance performance NN cord-023095-4dannjjm 3379 6 of of IN cord-023095-4dannjjm 3379 7 single single JJ cord-023095-4dannjjm 3379 8 random random JJ cord-023095-4dannjjm 3379 9 " " `` cord-023095-4dannjjm 3379 10 fasting fast VBG cord-023095-4dannjjm 3379 11 " " '' cord-023095-4dannjjm 3379 12 and and CC cord-023095-4dannjjm 3379 13 paired pair VBN cord-023095-4dannjjm 3379 14 serum serum NN cord-023095-4dannjjm 3379 15 bile bile NN cord-023095-4dannjjm 3379 16 acids acid NNS cord-023095-4dannjjm 3379 17 ( ( -LRB- cord-023095-4dannjjm 3379 18 SBA SBA NNP cord-023095-4dannjjm 3379 19 ; ; : cord-023095-4dannjjm 3379 20 pre pre JJ cord-023095-4dannjjm 3379 21 - - JJ cord-023095-4dannjjm 3379 22 and and CC cord-023095-4dannjjm 3379 23 2-hr 2-hr JJ cord-023095-4dannjjm 3379 24 post post NN cord-023095-4dannjjm 3379 25 - - JJ cord-023095-4dannjjm 3379 26 feeding feed VBG cord-023095-4dannjjm 3379 27 ) ) -RRB- cord-023095-4dannjjm 3379 28 in in IN cord-023095-4dannjjm 3379 29 a a DT cord-023095-4dannjjm 3379 30 large large JJ cord-023095-4dannjjm 3379 31 population population NN cord-023095-4dannjjm 3379 32 of of IN cord-023095-4dannjjm 3379 33 non non JJ cord-023095-4dannjjm 3379 34 - - JJ cord-023095-4dannjjm 3379 35 icteric icteric JJ cord-023095-4dannjjm 3379 36 dogs dog NNS cord-023095-4dannjjm 3379 37 with with IN cord-023095-4dannjjm 3379 38 confirmed confirm VBN cord-023095-4dannjjm 3379 39 PSS PSS NNP cord-023095-4dannjjm 3379 40 ( ( -LRB- cord-023095-4dannjjm 3379 41 abdominal abdominal JJ cord-023095-4dannjjm 3379 42 ultrasound ultrasound NN cord-023095-4dannjjm 3379 43 , , , cord-023095-4dannjjm 3379 44 colorectal colorectal JJ cord-023095-4dannjjm 3379 45 scintigraphy scintigraphy NN cord-023095-4dannjjm 3379 46 , , , cord-023095-4dannjjm 3379 47 radiographic radiographic JJ cord-023095-4dannjjm 3379 48 or or CC cord-023095-4dannjjm 3379 49 spiral spiral JJ cord-023095-4dannjjm 3379 50 - - HYPH cord-023095-4dannjjm 3379 51 CT ct NN cord-023095-4dannjjm 3379 52 portography portography NN cord-023095-4dannjjm 3379 53 , , , cord-023095-4dannjjm 3379 54 laparotomy laparotomy NN cord-023095-4dannjjm 3379 55 , , , cord-023095-4dannjjm 3379 56 or or CC cord-023095-4dannjjm 3379 57 necropsy necropsy JJ cord-023095-4dannjjm 3379 58 ) ) -RRB- cord-023095-4dannjjm 3379 59 . . . cord-023095-4dannjjm 3380 1 SBA SBA NNP cord-023095-4dannjjm 3380 2 were be VBD cord-023095-4dannjjm 3380 3 measured measure VBN cord-023095-4dannjjm 3380 4 by by IN cord-023095-4dannjjm 3380 5 enzymatic enzymatic JJ cord-023095-4dannjjm 3380 6 colorimetric colorimetric JJ cord-023095-4dannjjm 3380 7 method method NN cord-023095-4dannjjm 3380 8 with with IN cord-023095-4dannjjm 3380 9 normal normal JJ cord-023095-4dannjjm 3380 10 o o NN cord-023095-4dannjjm 3380 11 25 25 CD cord-023095-4dannjjm 3380 12 mmol mmol JJ cord-023095-4dannjjm 3380 13 / / SYM cord-023095-4dannjjm 3380 14 L. L. NNP cord-023095-4dannjjm 3380 15 Dogs Dogs NNP cord-023095-4dannjjm 3380 16 meeting meeting NN cord-023095-4dannjjm 3380 17 inclusion inclusion NN cord-023095-4dannjjm 3380 18 criteria criterion NNS cord-023095-4dannjjm 3381 1 ( ( -LRB- cord-023095-4dannjjm 3381 2 n n NN cord-023095-4dannjjm 3381 3 5 5 CD cord-023095-4dannjjm 3381 4 568 568 CD cord-023095-4dannjjm 3381 5 ) ) -RRB- cord-023095-4dannjjm 3381 6 included include VBD cord-023095-4dannjjm 3381 7 467 467 CD cord-023095-4dannjjm 3381 8 portosystemic portosystemic JJ cord-023095-4dannjjm 3381 9 vascular vascular JJ cord-023095-4dannjjm 3381 10 anomalies anomaly NNS cord-023095-4dannjjm 3381 11 ( ( -LRB- cord-023095-4dannjjm 3381 12 PSVA PSVA NNP cord-023095-4dannjjm 3381 13 ; ; : cord-023095-4dannjjm 3381 14 368 368 CD cord-023095-4dannjjm 3381 15 extrahepatic extrahepatic NN cord-023095-4dannjjm 3381 16 [ [ -LRB- cord-023095-4dannjjm 3381 17 E E NNP cord-023095-4dannjjm 3381 18 - - JJ cord-023095-4dannjjm 3381 19 PSVA PSVA NNP cord-023095-4dannjjm 3381 20 ] ] -RRB- cord-023095-4dannjjm 3381 21 , , , cord-023095-4dannjjm 3381 22 99 99 CD cord-023095-4dannjjm 3381 23 intrahepatic intrahepatic JJ cord-023095-4dannjjm 3382 1 [ [ -LRB- cord-023095-4dannjjm 3382 2 I I NNP cord-023095-4dannjjm 3382 3 - - HYPH cord-023095-4dannjjm 3382 4 PSVA PSVA NNP cord-023095-4dannjjm 3382 5 ] ] -RRB- cord-023095-4dannjjm 3382 6 ) ) -RRB- cord-023095-4dannjjm 3382 7 , , , cord-023095-4dannjjm 3382 8 and and CC cord-023095-4dannjjm 3382 9 101 101 CD cord-023095-4dannjjm 3382 10 acquired acquire VBD cord-023095-4dannjjm 3382 11 PSS PSS NNP cord-023095-4dannjjm 3382 12 ( ( -LRB- cord-023095-4dannjjm 3382 13 APSS APSS NNP cord-023095-4dannjjm 3382 14 ) ) -RRB- cord-023095-4dannjjm 3382 15 . . . cord-023095-4dannjjm 3383 1 Signalment signalment JJ cord-023095-4dannjjm 3383 2 and and CC cord-023095-4dannjjm 3383 3 laboratory laboratory NN cord-023095-4dannjjm 3383 4 parameters parameter NNS cord-023095-4dannjjm 3383 5 were be VBD cord-023095-4dannjjm 3383 6 recorded record VBN cord-023095-4dannjjm 3383 7 . . . cord-023095-4dannjjm 3384 1 Non non JJ cord-023095-4dannjjm 3384 2 - - JJ cord-023095-4dannjjm 3384 3 parametric parametric JJ cord-023095-4dannjjm 3384 4 statistical statistical JJ cord-023095-4dannjjm 3384 5 analyses analysis NNS cord-023095-4dannjjm 3384 6 were be VBD cord-023095-4dannjjm 3384 7 used use VBN cord-023095-4dannjjm 3384 8 , , , cord-023095-4dannjjm 3384 9 two two CD cord-023095-4dannjjm 3384 10 - - HYPH cord-023095-4dannjjm 3384 11 tailed tailed JJ cord-023095-4dannjjm 3384 12 P p NN cord-023095-4dannjjm 3384 13 o o NN cord-023095-4dannjjm 3384 14 0.05 0.05 CD cord-023095-4dannjjm 3384 15 applied apply VBN cord-023095-4dannjjm 3384 16 with with IN cord-023095-4dannjjm 3384 17 Bonferroni Bonferroni NNP cord-023095-4dannjjm 3384 18 corrections correction NNS cord-023095-4dannjjm 3384 19 . . . cord-023095-4dannjjm 3385 1 Median median JJ cord-023095-4dannjjm 3385 2 age age NN cord-023095-4dannjjm 3385 3 and and CC cord-023095-4dannjjm 3385 4 weight weight NN cord-023095-4dannjjm 3385 5 of of IN cord-023095-4dannjjm 3385 6 74 74 CD cord-023095-4dannjjm 3385 7 breeds breed NNS cord-023095-4dannjjm 3385 8 were be VBD cord-023095-4dannjjm 3385 9 1.2 1.2 CD cord-023095-4dannjjm 3385 10 ( ( -LRB- cord-023095-4dannjjm 3385 11 0.2 0.2 CD cord-023095-4dannjjm 3385 12 - - SYM cord-023095-4dannjjm 3385 13 12 12 CD cord-023095-4dannjjm 3385 14 ) ) -RRB- cord-023095-4dannjjm 3385 15 yrs yr NNS cord-023095-4dannjjm 3385 16 and and CC cord-023095-4dannjjm 3385 17 6.6 6.6 CD cord-023095-4dannjjm 3385 18 ( ( -LRB- cord-023095-4dannjjm 3385 19 0.2 0.2 CD cord-023095-4dannjjm 3385 20 - - SYM cord-023095-4dannjjm 3385 21 48 48 CD cord-023095-4dannjjm 3385 22 ) ) -RRB- cord-023095-4dannjjm 3385 23 kg kg NNS cord-023095-4dannjjm 3385 24 , , , cord-023095-4dannjjm 3385 25 with with IN cord-023095-4dannjjm 3385 26 equal equal JJ cord-023095-4dannjjm 3385 27 gender gender NN cord-023095-4dannjjm 3385 28 distribution distribution NN cord-023095-4dannjjm 3385 29 . . . cord-023095-4dannjjm 3386 1 Random random JJ cord-023095-4dannjjm 3386 2 " " `` cord-023095-4dannjjm 3386 3 fasting fast VBG cord-023095-4dannjjm 3386 4 " " '' cord-023095-4dannjjm 3386 5 SBA SBA NNP cord-023095-4dannjjm 3386 6 detected detect VBD cord-023095-4dannjjm 3386 7 90 90 CD cord-023095-4dannjjm 3386 8 % % NN cord-023095-4dannjjm 3386 9 PSVA PSVA NNP cord-023095-4dannjjm 3386 10 and and CC cord-023095-4dannjjm 3386 11 81 81 CD cord-023095-4dannjjm 3386 12 % % NN cord-023095-4dannjjm 3386 13 APSS APSS NNP cord-023095-4dannjjm 3386 14 , , , cord-023095-4dannjjm 3386 15 whereas whereas IN cord-023095-4dannjjm 3386 16 post post NN cord-023095-4dannjjm 3386 17 - - JJ cord-023095-4dannjjm 3386 18 feeding feeding JJ cord-023095-4dannjjm 3386 19 SBA SBA NNP cord-023095-4dannjjm 3386 20 detected detect VBD cord-023095-4dannjjm 3386 21 100 100 CD cord-023095-4dannjjm 3386 22 % % NN cord-023095-4dannjjm 3386 23 PSVA PSVA NNP cord-023095-4dannjjm 3386 24 and and CC cord-023095-4dannjjm 3386 25 98 98 CD cord-023095-4dannjjm 3386 26 % % NN cord-023095-4dannjjm 3386 27 APSS APSS NNP cord-023095-4dannjjm 3386 28 . . . cord-023095-4dannjjm 3387 1 Low Low NNP cord-023095-4dannjjm 3387 2 Protein Protein NNP cord-023095-4dannjjm 3387 3 - - HYPH cord-023095-4dannjjm 3387 4 C C NNP cord-023095-4dannjjm 3387 5 ( ( -LRB- cord-023095-4dannjjm 3387 6 o o NN cord-023095-4dannjjm 3387 7 70 70 CD cord-023095-4dannjjm 3387 8 % % NN cord-023095-4dannjjm 3387 9 activity activity NN cord-023095-4dannjjm 3387 10 ) ) -RRB- cord-023095-4dannjjm 3387 11 occurred occur VBD cord-023095-4dannjjm 3387 12 in in IN cord-023095-4dannjjm 3387 13 96 96 CD cord-023095-4dannjjm 3387 14 % % NN cord-023095-4dannjjm 3387 15 PSVA PSVA NNP cord-023095-4dannjjm 3387 16 and and CC cord-023095-4dannjjm 3387 17 74 74 CD cord-023095-4dannjjm 3387 18 % % NN cord-023095-4dannjjm 3387 19 APSS APSS NNP cord-023095-4dannjjm 3387 20 . . . cord-023095-4dannjjm 3388 1 Low low JJ cord-023095-4dannjjm 3388 2 MCV MCV NNP cord-023095-4dannjjm 3388 3 and and CC cord-023095-4dannjjm 3388 4 creatinine creatinine NN cord-023095-4dannjjm 3388 5 occurred occur VBD cord-023095-4dannjjm 3388 6 in in IN cord-023095-4dannjjm 3388 7 82 82 CD cord-023095-4dannjjm 3388 8 % % NN cord-023095-4dannjjm 3388 9 and and CC cord-023095-4dannjjm 3388 10 94 94 CD cord-023095-4dannjjm 3388 11 % % NN cord-023095-4dannjjm 3388 12 of of IN cord-023095-4dannjjm 3388 13 PSVA PSVA NNP cord-023095-4dannjjm 3388 14 dogs dog NNS cord-023095-4dannjjm 3388 15 , , , cord-023095-4dannjjm 3388 16 respectively respectively RB cord-023095-4dannjjm 3388 17 ; ; : cord-023095-4dannjjm 3388 18 other other JJ cord-023095-4dannjjm 3388 19 tests test NNS cord-023095-4dannjjm 3388 20 were be VBD cord-023095-4dannjjm 3388 21 less less RBR cord-023095-4dannjjm 3388 22 helpful helpful JJ cord-023095-4dannjjm 3388 23 . . . cord-023095-4dannjjm 3389 1 In in IN cord-023095-4dannjjm 3389 2 APSS APSS NNP cord-023095-4dannjjm 3389 3 , , , cord-023095-4dannjjm 3389 4 post post NN cord-023095-4dannjjm 3389 5 - - JJ cord-023095-4dannjjm 3389 6 feeding feeding JJ cord-023095-4dannjjm 3389 7 SBA SBA NNP cord-023095-4dannjjm 3389 8 was be VBD cord-023095-4dannjjm 3389 9 superior superior JJ cord-023095-4dannjjm 3389 10 . . . cord-023095-4dannjjm 3390 1 Compared compare VBN cord-023095-4dannjjm 3390 2 to to IN cord-023095-4dannjjm 3390 3 APSS APSS NNP cord-023095-4dannjjm 3390 4 , , , cord-023095-4dannjjm 3390 5 PSVA PSVA NNP cord-023095-4dannjjm 3390 6 had have VBD cord-023095-4dannjjm 3390 7 significantly significantly RB cord-023095-4dannjjm 3390 8 ( ( -LRB- cord-023095-4dannjjm 3390 9 P p NN cord-023095-4dannjjm 3390 10 0.002 0.002 CD cord-023095-4dannjjm 3390 11 ) ) -RRB- cord-023095-4dannjjm 3391 1 lower low JJR cord-023095-4dannjjm 3391 2 MCV MCV NNP cord-023095-4dannjjm 3391 3 , , , cord-023095-4dannjjm 3391 4 cholesterol cholesterol NN cord-023095-4dannjjm 3391 5 , , , cord-023095-4dannjjm 3391 6 BUN bun NN cord-023095-4dannjjm 3391 7 , , , cord-023095-4dannjjm 3391 8 creatinine creatinine NN cord-023095-4dannjjm 3391 9 , , , cord-023095-4dannjjm 3391 10 glucose glucose NN cord-023095-4dannjjm 3391 11 , , , cord-023095-4dannjjm 3391 12 and and CC cord-023095-4dannjjm 3391 13 Protein Protein NNP cord-023095-4dannjjm 3391 14 - - HYPH cord-023095-4dannjjm 3391 15 C. C. NNP cord-023095-4dannjjm 3392 1 Compared compare VBN cord-023095-4dannjjm 3392 2 to to IN cord-023095-4dannjjm 3392 3 E E NNP cord-023095-4dannjjm 3392 4 - - JJ cord-023095-4dannjjm 3392 5 PSVA PSVA NNP cord-023095-4dannjjm 3392 6 , , , cord-023095-4dannjjm 3392 7 I I NNP cord-023095-4dannjjm 3392 8 - - HYPH cord-023095-4dannjjm 3392 9 PSVA PSVA NNP cord-023095-4dannjjm 3392 10 had have VBD cord-023095-4dannjjm 3392 11 significantly significantly RB cord-023095-4dannjjm 3392 12 ( ( -LRB- cord-023095-4dannjjm 3392 13 P p NN cord-023095-4dannjjm 3392 14 0.009 0.009 CD cord-023095-4dannjjm 3392 15 ) ) -RRB- cord-023095-4dannjjm 3393 1 lower low JJR cord-023095-4dannjjm 3393 2 post post NN cord-023095-4dannjjm 3393 3 - - JJ cord-023095-4dannjjm 3393 4 feeding feeding JJ cord-023095-4dannjjm 3393 5 SBA SBA NNP cord-023095-4dannjjm 3393 6 , , , cord-023095-4dannjjm 3393 7 MCV MCV NNP cord-023095-4dannjjm 3393 8 , , , cord-023095-4dannjjm 3393 9 albumin albumin NN cord-023095-4dannjjm 3393 10 , , , cord-023095-4dannjjm 3393 11 urine urine NN cord-023095-4dannjjm 3393 12 specific specific JJ cord-023095-4dannjjm 3393 13 gravity gravity NN cord-023095-4dannjjm 3393 14 , , , cord-023095-4dannjjm 3393 15 and and CC cord-023095-4dannjjm 3393 16 Protein Protein NNP cord-023095-4dannjjm 3393 17 - - HYPH cord-023095-4dannjjm 3393 18 C C NNP cord-023095-4dannjjm 3393 19 but but CC cord-023095-4dannjjm 3393 20 higher high JJR cord-023095-4dannjjm 3393 21 cholesterol cholesterol NN cord-023095-4dannjjm 3393 22 and and CC cord-023095-4dannjjm 3393 23 glucose glucose NN cord-023095-4dannjjm 3393 24 . . . cord-023095-4dannjjm 3394 1 Post post NN cord-023095-4dannjjm 3394 2 - - JJ cord-023095-4dannjjm 3394 3 feeding feed VBG cord-023095-4dannjjm 3394 4 SBA SBA NNP cord-023095-4dannjjm 3394 5 reflect reflect VBP cord-023095-4dannjjm 3394 6 physiologically physiologically RB cord-023095-4dannjjm 3394 7 provoked provoke VBN cord-023095-4dannjjm 3394 8 bile bile NN cord-023095-4dannjjm 3394 9 acid acid NN cord-023095-4dannjjm 3394 10 challenge challenge NN cord-023095-4dannjjm 3394 11 and and CC cord-023095-4dannjjm 3394 12 should should MD cord-023095-4dannjjm 3394 13 be be VB cord-023095-4dannjjm 3394 14 the the DT cord-023095-4dannjjm 3394 15 preferred preferred JJ cord-023095-4dannjjm 3394 16 SBA SBA NNP cord-023095-4dannjjm 3394 17 test test NN cord-023095-4dannjjm 3394 18 in in IN cord-023095-4dannjjm 3394 19 non non JJ cord-023095-4dannjjm 3394 20 - - JJ cord-023095-4dannjjm 3394 21 icteric icteric JJ cord-023095-4dannjjm 3394 22 dogs dog NNS cord-023095-4dannjjm 3394 23 for for IN cord-023095-4dannjjm 3394 24 PSS PSS NNP cord-023095-4dannjjm 3394 25 detection detection NN cord-023095-4dannjjm 3394 26 . . . cord-023095-4dannjjm 3395 1 Protein protein NN cord-023095-4dannjjm 3395 2 - - HYPH cord-023095-4dannjjm 3395 3 C C NNP cord-023095-4dannjjm 3395 4 assists assist VBZ cord-023095-4dannjjm 3395 5 in in IN cord-023095-4dannjjm 3395 6 identifying identify VBG cord-023095-4dannjjm 3395 7 PSVA PSVA NNP cord-023095-4dannjjm 3395 8 but but CC cord-023095-4dannjjm 3395 9 its -PRON- PRP$ cord-023095-4dannjjm 3395 10 utility utility NN cord-023095-4dannjjm 3395 11 in in IN cord-023095-4dannjjm 3395 12 APSS APSS NNP cord-023095-4dannjjm 3395 13 may may MD cord-023095-4dannjjm 3395 14 be be VB cord-023095-4dannjjm 3395 15 complicated complicate VBN cord-023095-4dannjjm 3395 16 by by IN cord-023095-4dannjjm 3395 17 concurrent concurrent JJ cord-023095-4dannjjm 3395 18 coagulopathies coagulopathie NNS cord-023095-4dannjjm 3395 19 and and CC cord-023095-4dannjjm 3395 20 inflammation inflammation NN cord-023095-4dannjjm 3395 21 . . . cord-023095-4dannjjm 3396 1 This this DT cord-023095-4dannjjm 3396 2 study study NN cord-023095-4dannjjm 3396 3 compared compare VBD cord-023095-4dannjjm 3396 4 outcomes outcome NNS cord-023095-4dannjjm 3396 5 of of IN cord-023095-4dannjjm 3396 6 treatment treatment NN cord-023095-4dannjjm 3396 7 with with IN cord-023095-4dannjjm 3396 8 adjunctive adjunctive JJ cord-023095-4dannjjm 3396 9 nonsteroidal nonsteroidal JJ cord-023095-4dannjjm 3396 10 anti anti JJ cord-023095-4dannjjm 3396 11 - - JJ cord-023095-4dannjjm 3396 12 inflammatory inflammatory JJ cord-023095-4dannjjm 3396 13 drugs drug NNS cord-023095-4dannjjm 3396 14 ( ( -LRB- cord-023095-4dannjjm 3396 15 NSAIDs nsaid NNS cord-023095-4dannjjm 3396 16 ) ) -RRB- cord-023095-4dannjjm 3396 17 or or CC cord-023095-4dannjjm 3396 18 anti anti JJ cord-023095-4dannjjm 3396 19 - - JJ cord-023095-4dannjjm 3396 20 inflammatory inflammatory JJ cord-023095-4dannjjm 3396 21 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 3396 22 in in IN cord-023095-4dannjjm 3396 23 dogs dog NNS cord-023095-4dannjjm 3396 24 with with IN cord-023095-4dannjjm 3396 25 severe severe JJ cord-023095-4dannjjm 3396 26 pulmonary pulmonary JJ cord-023095-4dannjjm 3396 27 blastomycosis blastomycosis NN cord-023095-4dannjjm 3396 28 . . . cord-023095-4dannjjm 3397 1 Medical medical JJ cord-023095-4dannjjm 3397 2 records record NNS cord-023095-4dannjjm 3397 3 were be VBD cord-023095-4dannjjm 3397 4 reviewed review VBN cord-023095-4dannjjm 3397 5 for for IN cord-023095-4dannjjm 3397 6 dogs dog NNS cord-023095-4dannjjm 3397 7 diagnosed diagnose VBN cord-023095-4dannjjm 3397 8 with with IN cord-023095-4dannjjm 3397 9 blastomycosis blastomycosis NN cord-023095-4dannjjm 3397 10 at at IN cord-023095-4dannjjm 3397 11 the the DT cord-023095-4dannjjm 3397 12 University University NNP cord-023095-4dannjjm 3397 13 of of IN cord-023095-4dannjjm 3397 14 Illinois Illinois NNP cord-023095-4dannjjm 3397 15 Veterinary Veterinary NNP cord-023095-4dannjjm 3397 16 Teaching Teaching NNP cord-023095-4dannjjm 3397 17 Hospital Hospital NNP cord-023095-4dannjjm 3397 18 between between IN cord-023095-4dannjjm 3397 19 1992 1992 CD cord-023095-4dannjjm 3397 20 and and CC cord-023095-4dannjjm 3397 21 2007 2007 CD cord-023095-4dannjjm 3397 22 . . . cord-023095-4dannjjm 3398 1 Dogs dog NNS cord-023095-4dannjjm 3398 2 with with IN cord-023095-4dannjjm 3398 3 a a DT cord-023095-4dannjjm 3398 4 presenting present VBG cord-023095-4dannjjm 3398 5 PaO pao NN cord-023095-4dannjjm 3398 6 2 2 CD cord-023095-4dannjjm 3398 7 of of IN cord-023095-4dannjjm 3398 8 80 80 CD cord-023095-4dannjjm 3398 9 mmHg mmHg NNS cord-023095-4dannjjm 3398 10 , , , cord-023095-4dannjjm 3398 11 and and CC cord-023095-4dannjjm 3398 12 clinical clinical JJ cord-023095-4dannjjm 3398 13 or or CC cord-023095-4dannjjm 3398 14 radiographic radiographic JJ cord-023095-4dannjjm 3398 15 signs sign NNS cord-023095-4dannjjm 3398 16 of of IN cord-023095-4dannjjm 3398 17 respiratory respiratory JJ cord-023095-4dannjjm 3398 18 blastomycosis blastomycosis NN cord-023095-4dannjjm 3398 19 were be VBD cord-023095-4dannjjm 3398 20 included include VBN cord-023095-4dannjjm 3398 21 . . . cord-023095-4dannjjm 3399 1 All all DT cord-023095-4dannjjm 3399 2 dogs dog NNS cord-023095-4dannjjm 3399 3 were be VBD cord-023095-4dannjjm 3399 4 treated treat VBN cord-023095-4dannjjm 3399 5 with with IN cord-023095-4dannjjm 3399 6 either either DT cord-023095-4dannjjm 3399 7 itraconazole itraconazole NNP cord-023095-4dannjjm 3399 8 , , , cord-023095-4dannjjm 3399 9 fluconazole fluconazole NN cord-023095-4dannjjm 3399 10 , , , cord-023095-4dannjjm 3399 11 amphotericin amphotericin NNS cord-023095-4dannjjm 3399 12 B b NN cord-023095-4dannjjm 3399 13 , , , cord-023095-4dannjjm 3399 14 or or CC cord-023095-4dannjjm 3399 15 a a DT cord-023095-4dannjjm 3399 16 combination combination NN cord-023095-4dannjjm 3399 17 of of IN cord-023095-4dannjjm 3399 18 these these DT cord-023095-4dannjjm 3399 19 . . . cord-023095-4dannjjm 3400 1 Group group NN cord-023095-4dannjjm 3400 2 1 1 CD cord-023095-4dannjjm 3400 3 ( ( -LRB- cord-023095-4dannjjm 3400 4 G1 G1 NNP cord-023095-4dannjjm 3400 5 ) ) -RRB- cord-023095-4dannjjm 3400 6 dogs dog NNS cord-023095-4dannjjm 3400 7 were be VBD cord-023095-4dannjjm 3400 8 treated treat VBN cord-023095-4dannjjm 3400 9 with with IN cord-023095-4dannjjm 3400 10 NSAIDs NSAIDs NNP cord-023095-4dannjjm 3400 11 and and CC cord-023095-4dannjjm 3400 12 Group Group NNP cord-023095-4dannjjm 3400 13 2 2 CD cord-023095-4dannjjm 3400 14 ( ( -LRB- cord-023095-4dannjjm 3400 15 G2 G2 NNP cord-023095-4dannjjm 3400 16 ) ) -RRB- cord-023095-4dannjjm 3400 17 dogs dog NNS cord-023095-4dannjjm 3400 18 were be VBD cord-023095-4dannjjm 3400 19 treated treat VBN cord-023095-4dannjjm 3400 20 with with IN cord-023095-4dannjjm 3400 21 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 3400 22 as as IN cord-023095-4dannjjm 3400 23 anti anti JJ cord-023095-4dannjjm 3400 24 - - JJ cord-023095-4dannjjm 3400 25 inflammatory inflammatory JJ cord-023095-4dannjjm 3400 26 adjunctive adjunctive JJ cord-023095-4dannjjm 3400 27 therapy therapy NN cord-023095-4dannjjm 3400 28 . . . cord-023095-4dannjjm 3401 1 The the DT cord-023095-4dannjjm 3401 2 following following JJ cord-023095-4dannjjm 3401 3 comparisons comparison NNS cord-023095-4dannjjm 3401 4 were be VBD cord-023095-4dannjjm 3401 5 made make VBN cord-023095-4dannjjm 3401 6 : : : cord-023095-4dannjjm 3401 7 days day NNS cord-023095-4dannjjm 3401 8 of of IN cord-023095-4dannjjm 3401 9 oxygen oxygen NN cord-023095-4dannjjm 3401 10 supplementation supplementation NN cord-023095-4dannjjm 3401 11 , , , cord-023095-4dannjjm 3401 12 days day NNS cord-023095-4dannjjm 3401 13 in in IN cord-023095-4dannjjm 3401 14 hospital hospital NN cord-023095-4dannjjm 3401 15 , , , cord-023095-4dannjjm 3401 16 survival survival NN cord-023095-4dannjjm 3401 17 to to TO cord-023095-4dannjjm 3401 18 discharge discharge NN cord-023095-4dannjjm 3401 19 , , , cord-023095-4dannjjm 3401 20 and and CC cord-023095-4dannjjm 3401 21 long long JJ cord-023095-4dannjjm 3401 22 term term NN cord-023095-4dannjjm 3401 23 patient patient NN cord-023095-4dannjjm 3401 24 survival survival NN cord-023095-4dannjjm 3401 25 . . . cord-023095-4dannjjm 3402 1 Mann Mann NNP cord-023095-4dannjjm 3402 2 - - HYPH cord-023095-4dannjjm 3402 3 Whitney Whitney NNP cord-023095-4dannjjm 3402 4 U U NNP cord-023095-4dannjjm 3402 5 tests test NNS cord-023095-4dannjjm 3402 6 and and CC cord-023095-4dannjjm 3402 7 Chi Chi NNP cord-023095-4dannjjm 3402 8 - - HYPH cord-023095-4dannjjm 3402 9 squared square VBN cord-023095-4dannjjm 3402 10 tests test NNS cord-023095-4dannjjm 3402 11 were be VBD cord-023095-4dannjjm 3402 12 performed perform VBN cord-023095-4dannjjm 3402 13 on on IN cord-023095-4dannjjm 3402 14 continuous continuous JJ cord-023095-4dannjjm 3402 15 and and CC cord-023095-4dannjjm 3402 16 categorical categorical JJ cord-023095-4dannjjm 3402 17 data datum NNS cord-023095-4dannjjm 3402 18 , , , cord-023095-4dannjjm 3402 19 respectively respectively RB cord-023095-4dannjjm 3402 20 . . . cord-023095-4dannjjm 3403 1 P p NN cord-023095-4dannjjm 3403 2 o o NN cord-023095-4dannjjm 3403 3 0.05 0.05 CD cord-023095-4dannjjm 3403 4 was be VBD cord-023095-4dannjjm 3403 5 considered consider VBN cord-023095-4dannjjm 3403 6 significant significant JJ cord-023095-4dannjjm 3403 7 . . . cord-023095-4dannjjm 3404 1 Sixty sixty CD cord-023095-4dannjjm 3404 2 - - HYPH cord-023095-4dannjjm 3404 3 eight eight CD cord-023095-4dannjjm 3404 4 dogs dog NNS cord-023095-4dannjjm 3404 5 fit fit VBP cord-023095-4dannjjm 3404 6 the the DT cord-023095-4dannjjm 3404 7 inclusion inclusion NN cord-023095-4dannjjm 3404 8 criteria criterion NNS cord-023095-4dannjjm 3404 9 . . . cord-023095-4dannjjm 3405 1 G1 G1 NNP cord-023095-4dannjjm 3405 2 consisted consist VBD cord-023095-4dannjjm 3405 3 of of IN cord-023095-4dannjjm 3405 4 31 31 CD cord-023095-4dannjjm 3405 5 dogs dog NNS cord-023095-4dannjjm 3405 6 and and CC cord-023095-4dannjjm 3405 7 G2 G2 NNP cord-023095-4dannjjm 3405 8 consisted consist VBD cord-023095-4dannjjm 3405 9 of of IN cord-023095-4dannjjm 3405 10 37 37 CD cord-023095-4dannjjm 3405 11 dogs dog NNS cord-023095-4dannjjm 3405 12 . . . cord-023095-4dannjjm 3406 1 The the DT cord-023095-4dannjjm 3406 2 two two CD cord-023095-4dannjjm 3406 3 groups group NNS cord-023095-4dannjjm 3406 4 were be VBD cord-023095-4dannjjm 3406 5 found find VBN cord-023095-4dannjjm 3406 6 to to TO cord-023095-4dannjjm 3406 7 be be VB cord-023095-4dannjjm 3406 8 similar similar JJ cord-023095-4dannjjm 3406 9 in in IN cord-023095-4dannjjm 3406 10 weight weight NN cord-023095-4dannjjm 3406 11 , , , cord-023095-4dannjjm 3406 12 age age NN cord-023095-4dannjjm 3406 13 , , , cord-023095-4dannjjm 3406 14 and and CC cord-023095-4dannjjm 3406 15 sex sex NN cord-023095-4dannjjm 3406 16 distribution distribution NN cord-023095-4dannjjm 3406 17 . . . cord-023095-4dannjjm 3407 1 There there EX cord-023095-4dannjjm 3407 2 was be VBD cord-023095-4dannjjm 3407 3 no no DT cord-023095-4dannjjm 3407 4 significant significant JJ cord-023095-4dannjjm 3407 5 difference difference NN cord-023095-4dannjjm 3407 6 between between IN cord-023095-4dannjjm 3407 7 the the DT cord-023095-4dannjjm 3407 8 two two CD cord-023095-4dannjjm 3407 9 groups group NNS cord-023095-4dannjjm 3407 10 with with IN cord-023095-4dannjjm 3407 11 regard regard NN cord-023095-4dannjjm 3407 12 to to IN cord-023095-4dannjjm 3407 13 duration duration NN cord-023095-4dannjjm 3407 14 of of IN cord-023095-4dannjjm 3407 15 oxygen oxygen NN cord-023095-4dannjjm 3407 16 supplementation supplementation NN cord-023095-4dannjjm 3407 17 , , , cord-023095-4dannjjm 3407 18 duration duration NN cord-023095-4dannjjm 3407 19 of of IN cord-023095-4dannjjm 3407 20 hospitalization hospitalization NN cord-023095-4dannjjm 3407 21 , , , cord-023095-4dannjjm 3407 22 survival survival NN cord-023095-4dannjjm 3407 23 to to TO cord-023095-4dannjjm 3407 24 discharge discharge NN cord-023095-4dannjjm 3407 25 , , , cord-023095-4dannjjm 3407 26 and and CC cord-023095-4dannjjm 3407 27 patient patient JJ cord-023095-4dannjjm 3407 28 survival survival NN cord-023095-4dannjjm 3407 29 . . . cord-023095-4dannjjm 3408 1 There there EX cord-023095-4dannjjm 3408 2 does do VBZ cord-023095-4dannjjm 3408 3 not not RB cord-023095-4dannjjm 3408 4 appear appear VB cord-023095-4dannjjm 3408 5 to to TO cord-023095-4dannjjm 3408 6 be be VB cord-023095-4dannjjm 3408 7 a a DT cord-023095-4dannjjm 3408 8 difference difference NN cord-023095-4dannjjm 3408 9 between between IN cord-023095-4dannjjm 3408 10 the the DT cord-023095-4dannjjm 3408 11 clinical clinical JJ cord-023095-4dannjjm 3408 12 course course NN cord-023095-4dannjjm 3408 13 or or CC cord-023095-4dannjjm 3408 14 patient patient JJ cord-023095-4dannjjm 3408 15 outcomes outcome NNS cord-023095-4dannjjm 3408 16 between between IN cord-023095-4dannjjm 3408 17 groups group NNS cord-023095-4dannjjm 3408 18 of of IN cord-023095-4dannjjm 3408 19 dogs dog NNS cord-023095-4dannjjm 3408 20 with with IN cord-023095-4dannjjm 3408 21 severe severe JJ cord-023095-4dannjjm 3408 22 pulmonary pulmonary JJ cord-023095-4dannjjm 3408 23 blastomycosis blastomycosis NN cord-023095-4dannjjm 3408 24 treated treat VBN cord-023095-4dannjjm 3408 25 with with IN cord-023095-4dannjjm 3408 26 NSAIDs nsaids JJ cord-023095-4dannjjm 3408 27 or or CC cord-023095-4dannjjm 3408 28 anti anti JJ cord-023095-4dannjjm 3408 29 - - JJ cord-023095-4dannjjm 3408 30 inflammatory inflammatory JJ cord-023095-4dannjjm 3408 31 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 3408 32 . . . cord-023095-4dannjjm 3409 1 Further further JJ cord-023095-4dannjjm 3409 2 studies study NNS cord-023095-4dannjjm 3409 3 need need VBP cord-023095-4dannjjm 3409 4 to to TO cord-023095-4dannjjm 3409 5 be be VB cord-023095-4dannjjm 3409 6 performed perform VBN cord-023095-4dannjjm 3409 7 to to TO cord-023095-4dannjjm 3409 8 fully fully RB cord-023095-4dannjjm 3409 9 evaluate evaluate VB cord-023095-4dannjjm 3409 10 the the DT cord-023095-4dannjjm 3409 11 impact impact NN cord-023095-4dannjjm 3409 12 these these DT cord-023095-4dannjjm 3409 13 adjunct adjunct JJ cord-023095-4dannjjm 3409 14 treatments treatment NNS cord-023095-4dannjjm 3409 15 have have VBP cord-023095-4dannjjm 3409 16 on on IN cord-023095-4dannjjm 3409 17 prevention prevention NN cord-023095-4dannjjm 3409 18 of of IN cord-023095-4dannjjm 3409 19 ARDs ard NNS cord-023095-4dannjjm 3409 20 and and CC cord-023095-4dannjjm 3409 21 additional additional JJ cord-023095-4dannjjm 3409 22 respiratory respiratory JJ cord-023095-4dannjjm 3409 23 complications complication NNS cord-023095-4dannjjm 3409 24 . . . cord-023095-4dannjjm 3410 1 Diagnosis diagnosis NN cord-023095-4dannjjm 3410 2 of of IN cord-023095-4dannjjm 3410 3 feline feline JJ cord-023095-4dannjjm 3410 4 Histoplasma Histoplasma NNP cord-023095-4dannjjm 3410 5 capsulatum capsulatum NN cord-023095-4dannjjm 3410 6 infection infection NN cord-023095-4dannjjm 3410 7 traditionally traditionally RB cord-023095-4dannjjm 3410 8 relies rely VBZ cord-023095-4dannjjm 3410 9 upon upon IN cord-023095-4dannjjm 3410 10 identification identification NN cord-023095-4dannjjm 3410 11 of of IN cord-023095-4dannjjm 3410 12 organisms organism NNS cord-023095-4dannjjm 3410 13 in in IN cord-023095-4dannjjm 3410 14 circulating circulate VBG cord-023095-4dannjjm 3410 15 monocytes monocyte NNS cord-023095-4dannjjm 3410 16 or or CC cord-023095-4dannjjm 3410 17 affected affect VBN cord-023095-4dannjjm 3410 18 organs organ NNS cord-023095-4dannjjm 3410 19 . . . cord-023095-4dannjjm 3411 1 In in IN cord-023095-4dannjjm 3411 2 recent recent JJ cord-023095-4dannjjm 3411 3 years year NNS cord-023095-4dannjjm 3411 4 , , , cord-023095-4dannjjm 3411 5 an an DT cord-023095-4dannjjm 3411 6 antigen antigen NN cord-023095-4dannjjm 3411 7 assay assay NN cord-023095-4dannjjm 3411 8 ( ( -LRB- cord-023095-4dannjjm 3411 9 AA AA NNP cord-023095-4dannjjm 3411 10 ) ) -RRB- cord-023095-4dannjjm 3411 11 was be VBD cord-023095-4dannjjm 3411 12 developed develop VBN cord-023095-4dannjjm 3411 13 for for IN cord-023095-4dannjjm 3411 14 the the DT cord-023095-4dannjjm 3411 15 diagnosis diagnosis NN cord-023095-4dannjjm 3411 16 of of IN cord-023095-4dannjjm 3411 17 disseminated disseminate VBN cord-023095-4dannjjm 3411 18 histoplasmosis histoplasmosis NN cord-023095-4dannjjm 3411 19 in in IN cord-023095-4dannjjm 3411 20 human human JJ cord-023095-4dannjjm 3411 21 patients patient NNS cord-023095-4dannjjm 3411 22 , , , cord-023095-4dannjjm 3411 23 but but CC cord-023095-4dannjjm 3411 24 there there EX cord-023095-4dannjjm 3411 25 is be VBZ cord-023095-4dannjjm 3411 26 little little JJ cord-023095-4dannjjm 3411 27 information information NN cord-023095-4dannjjm 3411 28 describing describe VBG cord-023095-4dannjjm 3411 29 this this DT cord-023095-4dannjjm 3411 30 test test NN cord-023095-4dannjjm 3411 31 in in IN cord-023095-4dannjjm 3411 32 cats cat NNS cord-023095-4dannjjm 3411 33 . . . cord-023095-4dannjjm 3412 1 The the DT cord-023095-4dannjjm 3412 2 goal goal NN cord-023095-4dannjjm 3412 3 of of IN cord-023095-4dannjjm 3412 4 this this DT cord-023095-4dannjjm 3412 5 study study NN cord-023095-4dannjjm 3412 6 was be VBD cord-023095-4dannjjm 3412 7 to to TO cord-023095-4dannjjm 3412 8 determine determine VB cord-023095-4dannjjm 3412 9 the the DT cord-023095-4dannjjm 3412 10 sensitivity sensitivity NN cord-023095-4dannjjm 3412 11 and and CC cord-023095-4dannjjm 3412 12 specificity specificity NN cord-023095-4dannjjm 3412 13 of of IN cord-023095-4dannjjm 3412 14 H. H. NNP cord-023095-4dannjjm 3412 15 capsulatum capsulatum NN cord-023095-4dannjjm 3412 16 AA AA NNP cord-023095-4dannjjm 3412 17 in in IN cord-023095-4dannjjm 3412 18 cats cat NNS cord-023095-4dannjjm 3412 19 with with IN cord-023095-4dannjjm 3412 20 clinical clinical JJ cord-023095-4dannjjm 3412 21 disorders disorder NNS cord-023095-4dannjjm 3412 22 suggestive suggestive JJ cord-023095-4dannjjm 3412 23 of of IN cord-023095-4dannjjm 3412 24 histoplasmosis histoplasmosis NN cord-023095-4dannjjm 3412 25 . . . cord-023095-4dannjjm 3413 1 Urine urine NN cord-023095-4dannjjm 3413 2 and and CC cord-023095-4dannjjm 3413 3 serum serum NN cord-023095-4dannjjm 3413 4 H. h. NN cord-023095-4dannjjm 3413 5 capsulatum capsulatum NN cord-023095-4dannjjm 3413 6 AA AA NNP cord-023095-4dannjjm 3413 7 results result NNS cord-023095-4dannjjm 3413 8 for for IN cord-023095-4dannjjm 3413 9 feline feline JJ cord-023095-4dannjjm 3413 10 patients patient NNS cord-023095-4dannjjm 3413 11 from from IN cord-023095-4dannjjm 3413 12 3 3 CD cord-023095-4dannjjm 3413 13 veterinary veterinary JJ cord-023095-4dannjjm 3413 14 hospitals hospital NNS cord-023095-4dannjjm 3413 15 were be VBD cord-023095-4dannjjm 3413 16 evaluated evaluate VBN cord-023095-4dannjjm 3413 17 . . . cord-023095-4dannjjm 3414 1 Medical medical JJ cord-023095-4dannjjm 3414 2 records record NNS cord-023095-4dannjjm 3414 3 were be VBD cord-023095-4dannjjm 3414 4 reviewed review VBN cord-023095-4dannjjm 3414 5 for for IN cord-023095-4dannjjm 3414 6 confirmatory confirmatory JJ cord-023095-4dannjjm 3414 7 evidence evidence NN cord-023095-4dannjjm 3414 8 of of IN cord-023095-4dannjjm 3414 9 histoplasmosis histoplasmosis NN cord-023095-4dannjjm 3414 10 ( ( -LRB- cord-023095-4dannjjm 3414 11 based base VBN cord-023095-4dannjjm 3414 12 on on IN cord-023095-4dannjjm 3414 13 cytological cytological JJ cord-023095-4dannjjm 3414 14 or or CC cord-023095-4dannjjm 3414 15 histopathological histopathological JJ cord-023095-4dannjjm 3414 16 findings finding NNS cord-023095-4dannjjm 3414 17 ) ) -RRB- cord-023095-4dannjjm 3414 18 or or CC cord-023095-4dannjjm 3414 19 an an DT cord-023095-4dannjjm 3414 20 appropriately appropriately RB cord-023095-4dannjjm 3414 21 supported support VBN cord-023095-4dannjjm 3414 22 alternate alternate JJ cord-023095-4dannjjm 3414 23 diagnosis diagnosis NN cord-023095-4dannjjm 3414 24 . . . cord-023095-4dannjjm 3415 1 AA AA NNP cord-023095-4dannjjm 3415 2 results result NNS cord-023095-4dannjjm 3415 3 were be VBD cord-023095-4dannjjm 3415 4 available available JJ cord-023095-4dannjjm 3415 5 for for IN cord-023095-4dannjjm 3415 6 78 78 CD cord-023095-4dannjjm 3415 7 cats cat NNS cord-023095-4dannjjm 3415 8 ; ; : cord-023095-4dannjjm 3415 9 initial initial JJ cord-023095-4dannjjm 3415 10 testing testing NN cord-023095-4dannjjm 3415 11 was be VBD cord-023095-4dannjjm 3415 12 performed perform VBN cord-023095-4dannjjm 3415 13 on on IN cord-023095-4dannjjm 3415 14 72 72 CD cord-023095-4dannjjm 3415 15 urine urine NN cord-023095-4dannjjm 3415 16 samples sample NNS cord-023095-4dannjjm 3415 17 , , , cord-023095-4dannjjm 3415 18 6 6 CD cord-023095-4dannjjm 3415 19 serum serum NN cord-023095-4dannjjm 3415 20 samples sample NNS cord-023095-4dannjjm 3415 21 , , , cord-023095-4dannjjm 3415 22 and and CC cord-023095-4dannjjm 3415 23 1 1 CD cord-023095-4dannjjm 3415 24 unspecified unspecified JJ cord-023095-4dannjjm 3415 25 sample sample NN cord-023095-4dannjjm 3415 26 . . . cord-023095-4dannjjm 3416 1 Of of IN cord-023095-4dannjjm 3416 2 these these DT cord-023095-4dannjjm 3416 3 cats cat NNS cord-023095-4dannjjm 3416 4 , , , cord-023095-4dannjjm 3416 5 17/78 17/78 CD cord-023095-4dannjjm 3416 6 had have VBD cord-023095-4dannjjm 3416 7 a a DT cord-023095-4dannjjm 3416 8 definitive definitive JJ cord-023095-4dannjjm 3416 9 diagnosis diagnosis NN cord-023095-4dannjjm 3416 10 of of IN cord-023095-4dannjjm 3416 11 histoplasmosis histoplasmosis NN cord-023095-4dannjjm 3416 12 based base VBN cord-023095-4dannjjm 3416 13 on on IN cord-023095-4dannjjm 3416 14 organism organism NN cord-023095-4dannjjm 3416 15 identification identification NN cord-023095-4dannjjm 3416 16 , , , cord-023095-4dannjjm 3416 17 and and CC cord-023095-4dannjjm 3416 18 10 10 CD cord-023095-4dannjjm 3416 19 had have VBD cord-023095-4dannjjm 3416 20 a a DT cord-023095-4dannjjm 3416 21 definitive definitive JJ cord-023095-4dannjjm 3416 22 alternate alternate JJ cord-023095-4dannjjm 3416 23 diagnosis diagnosis NN cord-023095-4dannjjm 3416 24 ( ( -LRB- cord-023095-4dannjjm 3416 25 e.g. e.g. RB cord-023095-4dannjjm 3416 26 , , , cord-023095-4dannjjm 3416 27 neoplasia neoplasia NN cord-023095-4dannjjm 3416 28 , , , cord-023095-4dannjjm 3416 29 other other JJ cord-023095-4dannjjm 3416 30 infection infection NN cord-023095-4dannjjm 3416 31 ) ) -RRB- cord-023095-4dannjjm 3416 32 based base VBN cord-023095-4dannjjm 3416 33 on on IN cord-023095-4dannjjm 3416 34 necropsy necropsy JJ cord-023095-4dannjjm 3416 35 findings finding NNS cord-023095-4dannjjm 3416 36 ( ( -LRB- cord-023095-4dannjjm 3416 37 n n NN cord-023095-4dannjjm 3416 38 5 5 CD cord-023095-4dannjjm 3416 39 5 5 CD cord-023095-4dannjjm 3416 40 ) ) -RRB- cord-023095-4dannjjm 3416 41 or or CC cord-023095-4dannjjm 3416 42 other other JJ cord-023095-4dannjjm 3416 43 clinical clinical JJ cord-023095-4dannjjm 3416 44 data datum NNS cord-023095-4dannjjm 3416 45 ( ( -LRB- cord-023095-4dannjjm 3416 46 n n NN cord-023095-4dannjjm 3416 47 5 5 CD cord-023095-4dannjjm 3416 48 5 5 CD cord-023095-4dannjjm 3416 49 ) ) -RRB- cord-023095-4dannjjm 3416 50 . . . cord-023095-4dannjjm 3417 1 An an DT cord-023095-4dannjjm 3417 2 additional additional JJ cord-023095-4dannjjm 3417 3 16 16 CD cord-023095-4dannjjm 3417 4 cats cat NNS cord-023095-4dannjjm 3417 5 had have VBD cord-023095-4dannjjm 3417 6 a a DT cord-023095-4dannjjm 3417 7 clinical clinical JJ cord-023095-4dannjjm 3417 8 alternate alternate JJ cord-023095-4dannjjm 3417 9 diagnosis diagnosis NN cord-023095-4dannjjm 3417 10 with with IN cord-023095-4dannjjm 3417 11 no no DT cord-023095-4dannjjm 3417 12 cytological cytological JJ cord-023095-4dannjjm 3417 13 or or CC cord-023095-4dannjjm 3417 14 histopathological histopathological JJ cord-023095-4dannjjm 3417 15 evidence evidence NN cord-023095-4dannjjm 3417 16 of of IN cord-023095-4dannjjm 3417 17 histoplasmosis histoplasmosis NN cord-023095-4dannjjm 3417 18 in in IN cord-023095-4dannjjm 3417 19 the the DT cord-023095-4dannjjm 3417 20 affected affected JJ cord-023095-4dannjjm 3417 21 body body NN cord-023095-4dannjjm 3417 22 system(s system(s NNP cord-023095-4dannjjm 3417 23 ) ) -RRB- cord-023095-4dannjjm 3417 24 . . . cord-023095-4dannjjm 3418 1 The the DT cord-023095-4dannjjm 3418 2 remaining remain VBG cord-023095-4dannjjm 3418 3 cats cat NNS cord-023095-4dannjjm 3418 4 had have VBD cord-023095-4dannjjm 3418 5 unverified unverified JJ cord-023095-4dannjjm 3418 6 histoplasmosis histoplasmosis NN cord-023095-4dannjjm 3418 7 ( ( -LRB- cord-023095-4dannjjm 3418 8 n n NN cord-023095-4dannjjm 3418 9 5 5 CD cord-023095-4dannjjm 3418 10 9 9 CD cord-023095-4dannjjm 3418 11 ) ) -RRB- cord-023095-4dannjjm 3418 12 or or CC cord-023095-4dannjjm 3418 13 an an DT cord-023095-4dannjjm 3418 14 open open JJ cord-023095-4dannjjm 3418 15 diagnosis diagnosis NN cord-023095-4dannjjm 3418 16 ( ( -LRB- cord-023095-4dannjjm 3418 17 n n NN cord-023095-4dannjjm 3418 18 5 5 CD cord-023095-4dannjjm 3418 19 26 26 CD cord-023095-4dannjjm 3418 20 ) ) -RRB- cord-023095-4dannjjm 3418 21 . . . cord-023095-4dannjjm 3419 1 Of of IN cord-023095-4dannjjm 3419 2 the the DT cord-023095-4dannjjm 3419 3 17 17 CD cord-023095-4dannjjm 3419 4 cats cat NNS cord-023095-4dannjjm 3419 5 with with IN cord-023095-4dannjjm 3419 6 confirmed confirm VBN cord-023095-4dannjjm 3419 7 histoplasmosis histoplasmosis NN cord-023095-4dannjjm 3419 8 , , , cord-023095-4dannjjm 3419 9 16 16 CD cord-023095-4dannjjm 3419 10 were be VBD cord-023095-4dannjjm 3419 11 positive positive JJ cord-023095-4dannjjm 3419 12 on on IN cord-023095-4dannjjm 3419 13 initial initial JJ cord-023095-4dannjjm 3419 14 urine urine NN cord-023095-4dannjjm 3419 15 AA AA NNP cord-023095-4dannjjm 3419 16 . . . cord-023095-4dannjjm 3420 1 One one CD cord-023095-4dannjjm 3420 2 cat cat NN cord-023095-4dannjjm 3420 3 ( ( -LRB- cord-023095-4dannjjm 3420 4 with with IN cord-023095-4dannjjm 3420 5 rectal rectal JJ cord-023095-4dannjjm 3420 6 involvement involvement NN cord-023095-4dannjjm 3420 7 ) ) -RRB- cord-023095-4dannjjm 3420 8 was be VBD cord-023095-4dannjjm 3420 9 negative negative JJ cord-023095-4dannjjm 3420 10 , , , cord-023095-4dannjjm 3420 11 indicating indicate VBG cord-023095-4dannjjm 3420 12 a a DT cord-023095-4dannjjm 3420 13 test test NN cord-023095-4dannjjm 3420 14 sensitivity sensitivity NN cord-023095-4dannjjm 3420 15 of of IN cord-023095-4dannjjm 3420 16 94 94 CD cord-023095-4dannjjm 3420 17 % % NN cord-023095-4dannjjm 3420 18 . . . cord-023095-4dannjjm 3421 1 One one CD cord-023095-4dannjjm 3421 2 cat cat NN cord-023095-4dannjjm 3421 3 was be VBD cord-023095-4dannjjm 3421 4 positive positive JJ cord-023095-4dannjjm 3421 5 on on IN cord-023095-4dannjjm 3421 6 urine urine NN cord-023095-4dannjjm 3421 7 AA aa NN cord-023095-4dannjjm 3421 8 but but CC cord-023095-4dannjjm 3421 9 negative negative JJ cord-023095-4dannjjm 3421 10 on on IN cord-023095-4dannjjm 3421 11 serum serum NN cord-023095-4dannjjm 3421 12 AA aa NN cord-023095-4dannjjm 3421 13 . . . cord-023095-4dannjjm 3422 1 All all DT cord-023095-4dannjjm 3422 2 of of IN cord-023095-4dannjjm 3422 3 the the DT cord-023095-4dannjjm 3422 4 26 26 CD cord-023095-4dannjjm 3422 5 cats cat NNS cord-023095-4dannjjm 3422 6 with with IN cord-023095-4dannjjm 3422 7 definitive definitive JJ cord-023095-4dannjjm 3422 8 or or CC cord-023095-4dannjjm 3422 9 clinical clinical JJ cord-023095-4dannjjm 3422 10 alternate alternate JJ cord-023095-4dannjjm 3422 11 diagnoses diagnosis NNS cord-023095-4dannjjm 3422 12 had have VBD cord-023095-4dannjjm 3422 13 negative negative JJ cord-023095-4dannjjm 3422 14 results result NNS cord-023095-4dannjjm 3422 15 on on IN cord-023095-4dannjjm 3422 16 the the DT cord-023095-4dannjjm 3422 17 AA AA NNP cord-023095-4dannjjm 3422 18 , , , cord-023095-4dannjjm 3422 19 suggesting suggest VBG cord-023095-4dannjjm 3422 20 an an DT cord-023095-4dannjjm 3422 21 excellent excellent JJ cord-023095-4dannjjm 3422 22 specificity specificity NN cord-023095-4dannjjm 3422 23 ( ( -LRB- cord-023095-4dannjjm 3422 24 100 100 CD cord-023095-4dannjjm 3422 25 % % NN cord-023095-4dannjjm 3422 26 ) ) -RRB- cord-023095-4dannjjm 3422 27 . . . cord-023095-4dannjjm 3423 1 However however RB cord-023095-4dannjjm 3423 2 , , , cord-023095-4dannjjm 3423 3 this this DT cord-023095-4dannjjm 3423 4 result result NN cord-023095-4dannjjm 3423 5 should should MD cord-023095-4dannjjm 3423 6 be be VB cord-023095-4dannjjm 3423 7 interpreted interpret VBN cord-023095-4dannjjm 3423 8 with with IN cord-023095-4dannjjm 3423 9 caution caution NN cord-023095-4dannjjm 3423 10 , , , cord-023095-4dannjjm 3423 11 as as IN cord-023095-4dannjjm 3423 12 the the DT cord-023095-4dannjjm 3423 13 possibility possibility NN cord-023095-4dannjjm 3423 14 of of IN cord-023095-4dannjjm 3423 15 primary primary JJ cord-023095-4dannjjm 3423 16 or or CC cord-023095-4dannjjm 3423 17 concurrent concurrent JJ cord-023095-4dannjjm 3423 18 histoplasmosis histoplasmosis NN cord-023095-4dannjjm 3423 19 was be VBD cord-023095-4dannjjm 3423 20 only only RB cord-023095-4dannjjm 3423 21 definitively definitively RB cord-023095-4dannjjm 3423 22 excluded exclude VBN cord-023095-4dannjjm 3423 23 in in IN cord-023095-4dannjjm 3423 24 the the DT cord-023095-4dannjjm 3423 25 5 5 CD cord-023095-4dannjjm 3423 26 patients patient NNS cord-023095-4dannjjm 3423 27 who who WP cord-023095-4dannjjm 3423 28 underwent undergo VBD cord-023095-4dannjjm 3423 29 necropsy necropsy JJ cord-023095-4dannjjm 3423 30 examination examination NN cord-023095-4dannjjm 3423 31 . . . cord-023095-4dannjjm 3424 1 These these DT cord-023095-4dannjjm 3424 2 findings finding NNS cord-023095-4dannjjm 3424 3 suggest suggest VBP cord-023095-4dannjjm 3424 4 that that IN cord-023095-4dannjjm 3424 5 the the DT cord-023095-4dannjjm 3424 6 AA AA NNP cord-023095-4dannjjm 3424 7 for for IN cord-023095-4dannjjm 3424 8 H. H. NNP cord-023095-4dannjjm 3424 9 capsulatum capsulatum NNP cord-023095-4dannjjm 3424 10 is be VBZ cord-023095-4dannjjm 3424 11 a a DT cord-023095-4dannjjm 3424 12 reliable reliable JJ cord-023095-4dannjjm 3424 13 diagnostic diagnostic JJ cord-023095-4dannjjm 3424 14 tool tool NN cord-023095-4dannjjm 3424 15 in in IN cord-023095-4dannjjm 3424 16 this this DT cord-023095-4dannjjm 3424 17 species specie NNS cord-023095-4dannjjm 3424 18 . . . cord-023095-4dannjjm 3425 1 A a DT cord-023095-4dannjjm 3425 2 positive positive JJ cord-023095-4dannjjm 3425 3 result result NN cord-023095-4dannjjm 3425 4 appears appear VBZ cord-023095-4dannjjm 3425 5 to to TO cord-023095-4dannjjm 3425 6 reliably reliably RB cord-023095-4dannjjm 3425 7 support support VB cord-023095-4dannjjm 3425 8 the the DT cord-023095-4dannjjm 3425 9 presence presence NN cord-023095-4dannjjm 3425 10 of of IN cord-023095-4dannjjm 3425 11 infection infection NN cord-023095-4dannjjm 3425 12 , , , cord-023095-4dannjjm 3425 13 but but CC cord-023095-4dannjjm 3425 14 a a DT cord-023095-4dannjjm 3425 15 small small JJ cord-023095-4dannjjm 3425 16 percentage percentage NN cord-023095-4dannjjm 3425 17 of of IN cord-023095-4dannjjm 3425 18 infected infected JJ cord-023095-4dannjjm 3425 19 cats cat NNS cord-023095-4dannjjm 3425 20 may may MD cord-023095-4dannjjm 3425 21 be be VB cord-023095-4dannjjm 3425 22 negative negative JJ cord-023095-4dannjjm 3425 23 on on IN cord-023095-4dannjjm 3425 24 AA AA NNP cord-023095-4dannjjm 3425 25 . . . cord-023095-4dannjjm 3426 1 In in IN cord-023095-4dannjjm 3426 2 addition addition NN cord-023095-4dannjjm 3426 3 , , , cord-023095-4dannjjm 3426 4 tests test NNS cord-023095-4dannjjm 3426 5 performed perform VBN cord-023095-4dannjjm 3426 6 on on IN cord-023095-4dannjjm 3426 7 urine urine NN cord-023095-4dannjjm 3426 8 may may MD cord-023095-4dannjjm 3426 9 be be VB cord-023095-4dannjjm 3426 10 more more RBR cord-023095-4dannjjm 3426 11 sensitive sensitive JJ cord-023095-4dannjjm 3426 12 that that IN cord-023095-4dannjjm 3426 13 those those DT cord-023095-4dannjjm 3426 14 performed perform VBN cord-023095-4dannjjm 3426 15 on on IN cord-023095-4dannjjm 3426 16 serum serum NN cord-023095-4dannjjm 3426 17 . . . cord-023095-4dannjjm 3427 1 The the DT cord-023095-4dannjjm 3427 2 purpose purpose NN cord-023095-4dannjjm 3427 3 of of IN cord-023095-4dannjjm 3427 4 this this DT cord-023095-4dannjjm 3427 5 study study NN cord-023095-4dannjjm 3427 6 was be VBD cord-023095-4dannjjm 3427 7 to to TO cord-023095-4dannjjm 3427 8 evaluate evaluate VB cord-023095-4dannjjm 3427 9 the the DT cord-023095-4dannjjm 3427 10 sensitivity sensitivity NN cord-023095-4dannjjm 3427 11 and and CC cord-023095-4dannjjm 3427 12 specificity specificity NN cord-023095-4dannjjm 3427 13 of of IN cord-023095-4dannjjm 3427 14 an an DT cord-023095-4dannjjm 3427 15 Aspergillus Aspergillus NNP cord-023095-4dannjjm 3427 16 galactomannan galactomannan NN cord-023095-4dannjjm 3427 17 antigen antigen NN cord-023095-4dannjjm 3427 18 enzyme enzyme NN cord-023095-4dannjjm 3427 19 immunoassay immunoassay NN cord-023095-4dannjjm 3427 20 ( ( -LRB- cord-023095-4dannjjm 3427 21 GA GA NNP cord-023095-4dannjjm 3427 22 - - HYPH cord-023095-4dannjjm 3427 23 EIA EIA NNP cord-023095-4dannjjm 3427 24 ) ) -RRB- cord-023095-4dannjjm 3427 25 for for IN cord-023095-4dannjjm 3427 26 the the DT cord-023095-4dannjjm 3427 27 diagnosis diagnosis NN cord-023095-4dannjjm 3427 28 of of IN cord-023095-4dannjjm 3427 29 canine canine JJ cord-023095-4dannjjm 3427 30 systemic systemic JJ cord-023095-4dannjjm 3427 31 aspergillosis aspergillosis NN cord-023095-4dannjjm 3427 32 . . . cord-023095-4dannjjm 3428 1 Serum serum NN cord-023095-4dannjjm 3428 2 and and CC cord-023095-4dannjjm 3428 3 urine urine NN cord-023095-4dannjjm 3428 4 samples sample NNS cord-023095-4dannjjm 3428 5 were be VBD cord-023095-4dannjjm 3428 6 collected collect VBN cord-023095-4dannjjm 3428 7 from from IN cord-023095-4dannjjm 3428 8 sick sick JJ cord-023095-4dannjjm 3428 9 dogs dog NNS cord-023095-4dannjjm 3428 10 at at IN cord-023095-4dannjjm 3428 11 2 2 CD cord-023095-4dannjjm 3428 12 hospitals hospital NNS cord-023095-4dannjjm 3428 13 ( ( -LRB- cord-023095-4dannjjm 3428 14 UCD UCD NNP cord-023095-4dannjjm 3428 15 and and CC cord-023095-4dannjjm 3428 16 TAMU TAMU NNP cord-023095-4dannjjm 3428 17 ) ) -RRB- cord-023095-4dannjjm 3428 18 . . . cord-023095-4dannjjm 3429 1 Group group NN cord-023095-4dannjjm 3429 2 1 1 CD cord-023095-4dannjjm 3429 3 dogs dog NNS cord-023095-4dannjjm 3429 4 were be VBD cord-023095-4dannjjm 3429 5 diagnosed diagnose VBN cord-023095-4dannjjm 3429 6 with with IN cord-023095-4dannjjm 3429 7 systemic systemic JJ cord-023095-4dannjjm 3429 8 aspergillosis aspergillosis NN cord-023095-4dannjjm 3429 9 using use VBG cord-023095-4dannjjm 3429 10 culture culture NN cord-023095-4dannjjm 3429 11 ( ( -LRB- cord-023095-4dannjjm 3429 12 sterile sterile JJ cord-023095-4dannjjm 3429 13 site site NN cord-023095-4dannjjm 3429 14 ) ) -RRB- cord-023095-4dannjjm 3429 15 or or CC cord-023095-4dannjjm 3429 16 microscopy microscopy NN cord-023095-4dannjjm 3429 17 and and CC cord-023095-4dannjjm 3429 18 culture culture NN cord-023095-4dannjjm 3429 19 ( ( -LRB- cord-023095-4dannjjm 3429 20 non non JJ cord-023095-4dannjjm 3429 21 - - JJ cord-023095-4dannjjm 3429 22 sterile sterile JJ cord-023095-4dannjjm 3429 23 site site NN cord-023095-4dannjjm 3429 24 ) ) -RRB- cord-023095-4dannjjm 3429 25 . . . cord-023095-4dannjjm 3430 1 Group group NN cord-023095-4dannjjm 3430 2 2 2 CD cord-023095-4dannjjm 3430 3 dogs dog NNS cord-023095-4dannjjm 3430 4 had have VBD cord-023095-4dannjjm 3430 5 clinical clinical JJ cord-023095-4dannjjm 3430 6 findings finding NNS cord-023095-4dannjjm 3430 7 suggestive suggestive JJ cord-023095-4dannjjm 3430 8 of of IN cord-023095-4dannjjm 3430 9 aspergillosis aspergillosis NN cord-023095-4dannjjm 3430 10 but but CC cord-023095-4dannjjm 3430 11 an an DT cord-023095-4dannjjm 3430 12 alternate alternate JJ cord-023095-4dannjjm 3430 13 diagnosis diagnosis NN cord-023095-4dannjjm 3430 14 was be VBD cord-023095-4dannjjm 3430 15 established establish VBN cord-023095-4dannjjm 3430 16 . . . cord-023095-4dannjjm 3431 1 Group group NN cord-023095-4dannjjm 3431 2 3 3 CD cord-023095-4dannjjm 3431 3 dogs dog NNS cord-023095-4dannjjm 3431 4 were be VBD cord-023095-4dannjjm 3431 5 not not RB cord-023095-4dannjjm 3431 6 suspected suspect VBN cord-023095-4dannjjm 3431 7 to to TO cord-023095-4dannjjm 3431 8 have have VB cord-023095-4dannjjm 3431 9 aspergillosis aspergillosis NN cord-023095-4dannjjm 3431 10 . . . cord-023095-4dannjjm 3432 1 Samples sample NNS cord-023095-4dannjjm 3432 2 were be VBD cord-023095-4dannjjm 3432 3 tested test VBN cord-023095-4dannjjm 3432 4 using use VBG cord-023095-4dannjjm 3432 5 the the DT cord-023095-4dannjjm 3432 6 GA GA NNP cord-023095-4dannjjm 3432 7 - - HYPH cord-023095-4dannjjm 3432 8 EIA EIA NNP cord-023095-4dannjjm 3432 9 and and CC cord-023095-4dannjjm 3432 10 results result NNS cord-023095-4dannjjm 3432 11 expressed express VBN cord-023095-4dannjjm 3432 12 as as IN cord-023095-4dannjjm 3432 13 a a DT cord-023095-4dannjjm 3432 14 galactomannan galactomannan NNP cord-023095-4dannjjm 3432 15 index index NN cord-023095-4dannjjm 3432 16 ( ( -LRB- cord-023095-4dannjjm 3432 17 GMI GMI NNP cord-023095-4dannjjm 3432 18 ) ) -RRB- cord-023095-4dannjjm 3432 19 . . . cord-023095-4dannjjm 3433 1 GMIs gmi NNS cord-023095-4dannjjm 3433 2 4 4 CD cord-023095-4dannjjm 3433 3 0.5 0.5 CD cord-023095-4dannjjm 3433 4 were be VBD cord-023095-4dannjjm 3433 5 considered consider VBN cord-023095-4dannjjm 3433 6 positive positive JJ cord-023095-4dannjjm 3433 7 . . . cord-023095-4dannjjm 3434 1 Comparisons comparison NNS cord-023095-4dannjjm 3434 2 were be VBD cord-023095-4dannjjm 3434 3 performed perform VBN cord-023095-4dannjjm 3434 4 using use VBG cord-023095-4dannjjm 3434 5 the the DT cord-023095-4dannjjm 3434 6 Mann Mann NNP cord-023095-4dannjjm 3434 7 - - HYPH cord-023095-4dannjjm 3434 8 Whitney Whitney NNP cord-023095-4dannjjm 3434 9 test test NN cord-023095-4dannjjm 3434 10 . . . cord-023095-4dannjjm 3435 1 There there EX cord-023095-4dannjjm 3435 2 were be VBD cord-023095-4dannjjm 3435 3 10 10 CD cord-023095-4dannjjm 3435 4 dogs dog NNS cord-023095-4dannjjm 3435 5 in in IN cord-023095-4dannjjm 3435 6 Group Group NNP cord-023095-4dannjjm 3435 7 1 1 CD cord-023095-4dannjjm 3435 8 , , , cord-023095-4dannjjm 3435 9 22 22 CD cord-023095-4dannjjm 3435 10 in in IN cord-023095-4dannjjm 3435 11 Group Group NNP cord-023095-4dannjjm 3435 12 2 2 CD cord-023095-4dannjjm 3435 13 , , , cord-023095-4dannjjm 3435 14 and and CC cord-023095-4dannjjm 3435 15 23 23 CD cord-023095-4dannjjm 3435 16 in in IN cord-023095-4dannjjm 3435 17 Group Group NNP cord-023095-4dannjjm 3435 18 3 3 CD cord-023095-4dannjjm 3435 19 . . . cord-023095-4dannjjm 3436 1 Serum serum NN cord-023095-4dannjjm 3436 2 was be VBD cord-023095-4dannjjm 3436 3 collected collect VBN cord-023095-4dannjjm 3436 4 from from IN cord-023095-4dannjjm 3436 5 all all DT cord-023095-4dannjjm 3436 6 dogs dog NNS cord-023095-4dannjjm 3436 7 , , , cord-023095-4dannjjm 3436 8 and and CC cord-023095-4dannjjm 3436 9 urine urine NN cord-023095-4dannjjm 3436 10 from from IN cord-023095-4dannjjm 3436 11 6 6 CD cord-023095-4dannjjm 3436 12 , , , cord-023095-4dannjjm 3436 13 9 9 CD cord-023095-4dannjjm 3436 14 , , , cord-023095-4dannjjm 3436 15 and and CC cord-023095-4dannjjm 3436 16 10 10 CD cord-023095-4dannjjm 3436 17 dogs dog NNS cord-023095-4dannjjm 3436 18 , , , cord-023095-4dannjjm 3436 19 respectively respectively RB cord-023095-4dannjjm 3436 20 . . . cord-023095-4dannjjm 3437 1 Serum serum NN cord-023095-4dannjjm 3437 2 GMIs gmi NNS cord-023095-4dannjjm 3437 3 did do VBD cord-023095-4dannjjm 3437 4 not not RB cord-023095-4dannjjm 3437 5 differ differ VB cord-023095-4dannjjm 3437 6 from from IN cord-023095-4dannjjm 3437 7 urine urine NN cord-023095-4dannjjm 3437 8 GMIs gmi NNS cord-023095-4dannjjm 3437 9 across across IN cord-023095-4dannjjm 3437 10 groups group NNS cord-023095-4dannjjm 3437 11 . . . cord-023095-4dannjjm 3438 1 Serum serum NN cord-023095-4dannjjm 3438 2 GMIs gmi NNS cord-023095-4dannjjm 3438 3 of of IN cord-023095-4dannjjm 3438 4 Group group NN cord-023095-4dannjjm 3438 5 1 1 CD cord-023095-4dannjjm 3438 6 dogs dog NNS cord-023095-4dannjjm 3438 7 were be VBD cord-023095-4dannjjm 3438 8 higher high JJR cord-023095-4dannjjm 3438 9 than than IN cord-023095-4dannjjm 3438 10 those those DT cord-023095-4dannjjm 3438 11 of of IN cord-023095-4dannjjm 3438 12 Group Group NNP cord-023095-4dannjjm 3438 13 2 2 CD cord-023095-4dannjjm 3438 14 and and CC cord-023095-4dannjjm 3438 15 Group Group NNP cord-023095-4dannjjm 3438 16 3 3 CD cord-023095-4dannjjm 3438 17 dogs dog NNS cord-023095-4dannjjm 3438 18 ( ( -LRB- cord-023095-4dannjjm 3438 19 p p NN cord-023095-4dannjjm 3438 20 o o NN cord-023095-4dannjjm 3438 21 0.0001 0.0001 CD cord-023095-4dannjjm 3438 22 ) ) -RRB- cord-023095-4dannjjm 3438 23 . . . cord-023095-4dannjjm 3439 1 Results result NNS cord-023095-4dannjjm 3439 2 from from IN cord-023095-4dannjjm 3439 3 dogs dog NNS cord-023095-4dannjjm 3439 4 in in IN cord-023095-4dannjjm 3439 5 Group Group NNP cord-023095-4dannjjm 3439 6 2 2 CD cord-023095-4dannjjm 3439 7 did do VBD cord-023095-4dannjjm 3439 8 not not RB cord-023095-4dannjjm 3439 9 differ differ VB cord-023095-4dannjjm 3439 10 from from IN cord-023095-4dannjjm 3439 11 those those DT cord-023095-4dannjjm 3439 12 in in IN cord-023095-4dannjjm 3439 13 Group Group NNP cord-023095-4dannjjm 3439 14 3 3 CD cord-023095-4dannjjm 3439 15 ( ( -LRB- cord-023095-4dannjjm 3439 16 p p NN cord-023095-4dannjjm 3439 17 5 5 CD cord-023095-4dannjjm 3439 18 0.43 0.43 CD cord-023095-4dannjjm 3439 19 ) ) -RRB- cord-023095-4dannjjm 3439 20 . . . cord-023095-4dannjjm 3440 1 Two two CD cord-023095-4dannjjm 3440 2 dogs dog NNS cord-023095-4dannjjm 3440 3 in in IN cord-023095-4dannjjm 3440 4 Group Group NNP cord-023095-4dannjjm 3440 5 1 1 CD cord-023095-4dannjjm 3440 6 tested test VBD cord-023095-4dannjjm 3440 7 negative negative JJ cord-023095-4dannjjm 3440 8 , , , cord-023095-4dannjjm 3440 9 but but CC cord-023095-4dannjjm 3440 10 had have VBD cord-023095-4dannjjm 3440 11 localized localize VBN cord-023095-4dannjjm 3440 12 pulmonary pulmonary JJ cord-023095-4dannjjm 3440 13 infections infection NNS cord-023095-4dannjjm 3440 14 . . . cord-023095-4dannjjm 3441 1 One one CD cord-023095-4dannjjm 3441 2 dog dog NN cord-023095-4dannjjm 3441 3 in in IN cord-023095-4dannjjm 3441 4 Group Group NNP cord-023095-4dannjjm 3441 5 2 2 CD cord-023095-4dannjjm 3441 6 , , , cord-023095-4dannjjm 3441 7 which which WDT cord-023095-4dannjjm 3441 8 had have VBD cord-023095-4dannjjm 3441 9 paecilomycosis paecilomycosis NN cord-023095-4dannjjm 3441 10 , , , cord-023095-4dannjjm 3441 11 tested test VBD cord-023095-4dannjjm 3441 12 positive positive JJ cord-023095-4dannjjm 3441 13 . . . cord-023095-4dannjjm 3442 1 Two two CD cord-023095-4dannjjm 3442 2 dogs dog NNS cord-023095-4dannjjm 3442 3 in in IN cord-023095-4dannjjm 3442 4 Group Group NNP cord-023095-4dannjjm 3442 5 3 3 CD cord-023095-4dannjjm 3442 6 tested test VBD cord-023095-4dannjjm 3442 7 positive positive JJ cord-023095-4dannjjm 3442 8 . . . cord-023095-4dannjjm 3443 1 One one CD cord-023095-4dannjjm 3443 2 was be VBD cord-023095-4dannjjm 3443 3 being be VBG cord-023095-4dannjjm 3443 4 treated treat VBN cord-023095-4dannjjm 3443 5 with with IN cord-023095-4dannjjm 3443 6 Plasmalyte Plasmalyte NNP cord-023095-4dannjjm 3443 7 . . . cord-023095-4dannjjm 3444 1 The the DT cord-023095-4dannjjm 3444 2 other other JJ cord-023095-4dannjjm 3444 3 had have VBD cord-023095-4dannjjm 3444 4 a a DT cord-023095-4dannjjm 3444 5 cutaneous cutaneous JJ cord-023095-4dannjjm 3444 6 opportunistic opportunistic JJ cord-023095-4dannjjm 3444 7 mycosis mycosis NN cord-023095-4dannjjm 3444 8 . . . cord-023095-4dannjjm 3445 1 These these DT cord-023095-4dannjjm 3445 2 data datum NNS cord-023095-4dannjjm 3445 3 support support VBP cord-023095-4dannjjm 3445 4 the the DT cord-023095-4dannjjm 3445 5 utility utility NN cord-023095-4dannjjm 3445 6 of of IN cord-023095-4dannjjm 3445 7 this this DT cord-023095-4dannjjm 3445 8 assay assay NN cord-023095-4dannjjm 3445 9 to to TO cord-023095-4dannjjm 3445 10 aid aid VB cord-023095-4dannjjm 3445 11 in in IN cord-023095-4dannjjm 3445 12 the the DT cord-023095-4dannjjm 3445 13 diagnosis diagnosis NN cord-023095-4dannjjm 3445 14 of of IN cord-023095-4dannjjm 3445 15 systemic systemic JJ cord-023095-4dannjjm 3445 16 aspergillosis aspergillosis NN cord-023095-4dannjjm 3445 17 in in IN cord-023095-4dannjjm 3445 18 dogs dog NNS cord-023095-4dannjjm 3445 19 . . . cord-023095-4dannjjm 3446 1 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3446 2 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3446 3 , , , cord-023095-4dannjjm 3446 4 an an DT cord-023095-4dannjjm 3446 5 Ixodes Ixodes NNP cord-023095-4dannjjm 3446 6 tick tick VB cord-023095-4dannjjm 3446 7 transmitted transmit VBN cord-023095-4dannjjm 3446 8 rickettsial rickettsial JJ cord-023095-4dannjjm 3446 9 bacterium bacterium NN cord-023095-4dannjjm 3446 10 has have VBZ cord-023095-4dannjjm 3446 11 a a DT cord-023095-4dannjjm 3446 12 wide wide JJ cord-023095-4dannjjm 3446 13 mammalian mammalian JJ cord-023095-4dannjjm 3446 14 host host NN cord-023095-4dannjjm 3446 15 range range NN cord-023095-4dannjjm 3446 16 that that WDT cord-023095-4dannjjm 3446 17 is be VBZ cord-023095-4dannjjm 3446 18 not not RB cord-023095-4dannjjm 3446 19 commonly commonly RB cord-023095-4dannjjm 3446 20 reported report VBN cord-023095-4dannjjm 3446 21 in in IN cord-023095-4dannjjm 3446 22 cats cat NNS cord-023095-4dannjjm 3446 23 . . . cord-023095-4dannjjm 3447 1 Clinical clinical JJ cord-023095-4dannjjm 3447 2 signs sign NNS cord-023095-4dannjjm 3447 3 in in IN cord-023095-4dannjjm 3447 4 humans human NNS cord-023095-4dannjjm 3447 5 , , , cord-023095-4dannjjm 3447 6 dogs dog NNS cord-023095-4dannjjm 3447 7 and and CC cord-023095-4dannjjm 3447 8 cats cat NNS cord-023095-4dannjjm 3447 9 are be VBP cord-023095-4dannjjm 3447 10 often often RB cord-023095-4dannjjm 3447 11 vague vague JJ cord-023095-4dannjjm 3447 12 and and CC cord-023095-4dannjjm 3447 13 include include VBP cord-023095-4dannjjm 3447 14 lethargy lethargy NN cord-023095-4dannjjm 3447 15 , , , cord-023095-4dannjjm 3447 16 anorexia anorexia NN cord-023095-4dannjjm 3447 17 and and CC cord-023095-4dannjjm 3447 18 malaise malaise NN cord-023095-4dannjjm 3447 19 . . . cord-023095-4dannjjm 3448 1 The the DT cord-023095-4dannjjm 3448 2 purpose purpose NN cord-023095-4dannjjm 3448 3 of of IN cord-023095-4dannjjm 3448 4 this this DT cord-023095-4dannjjm 3448 5 retrospective retrospective JJ cord-023095-4dannjjm 3448 6 study study NN cord-023095-4dannjjm 3448 7 was be VBD cord-023095-4dannjjm 3448 8 to to TO cord-023095-4dannjjm 3448 9 describe describe VB cord-023095-4dannjjm 3448 10 the the DT cord-023095-4dannjjm 3448 11 clinical clinical JJ cord-023095-4dannjjm 3448 12 signs sign NNS cord-023095-4dannjjm 3448 13 , , , cord-023095-4dannjjm 3448 14 laboratory laboratory NN cord-023095-4dannjjm 3448 15 data datum NNS cord-023095-4dannjjm 3448 16 and and CC cord-023095-4dannjjm 3448 17 response response NN cord-023095-4dannjjm 3448 18 to to IN cord-023095-4dannjjm 3448 19 treatment treatment NN cord-023095-4dannjjm 3448 20 in in IN cord-023095-4dannjjm 3448 21 cats cat NNS cord-023095-4dannjjm 3448 22 that that WDT cord-023095-4dannjjm 3448 23 tested test VBD cord-023095-4dannjjm 3448 24 positive positive JJ cord-023095-4dannjjm 3448 25 for for IN cord-023095-4dannjjm 3448 26 A. a. NN cord-023095-4dannjjm 3448 27 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3448 28 on on IN cord-023095-4dannjjm 3448 29 a a DT cord-023095-4dannjjm 3448 30 commercially commercially RB cord-023095-4dannjjm 3448 31 available available JJ cord-023095-4dannjjm 3448 32 PCR pcr NN cord-023095-4dannjjm 3448 33 of of IN cord-023095-4dannjjm 3448 34 peripheral peripheral JJ cord-023095-4dannjjm 3448 35 blood blood NN cord-023095-4dannjjm 3448 36 ( ( -LRB- cord-023095-4dannjjm 3448 37 FastPanel FastPanel NNP cord-023095-4dannjjm 3448 38 TM TM NNP cord-023095-4dannjjm 3448 39 ) ) -RRB- cord-023095-4dannjjm 3448 40 . . . cord-023095-4dannjjm 3449 1 This this DT cord-023095-4dannjjm 3449 2 study study NN cord-023095-4dannjjm 3449 3 describes describe VBZ cord-023095-4dannjjm 3449 4 and and CC cord-023095-4dannjjm 3449 5 reports report VBZ cord-023095-4dannjjm 3449 6 the the DT cord-023095-4dannjjm 3449 7 appearance appearance NN cord-023095-4dannjjm 3449 8 of of IN cord-023095-4dannjjm 3449 9 intracellular intracellular JJ cord-023095-4dannjjm 3449 10 morulae morulae NN cord-023095-4dannjjm 3449 11 in in IN cord-023095-4dannjjm 3449 12 feline feline JJ cord-023095-4dannjjm 3449 13 neutrophils neutrophil NNS cord-023095-4dannjjm 3449 14 contributing contribute VBG cord-023095-4dannjjm 3449 15 to to IN cord-023095-4dannjjm 3449 16 the the DT cord-023095-4dannjjm 3449 17 diagnosis diagnosis NN cord-023095-4dannjjm 3449 18 of of IN cord-023095-4dannjjm 3449 19 A. A. NNP cord-023095-4dannjjm 3449 20 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3449 21 . . . cord-023095-4dannjjm 3450 1 The the DT cord-023095-4dannjjm 3450 2 A. a. NN cord-023095-4dannjjm 3450 3 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3450 4 real real JJ cord-023095-4dannjjm 3450 5 - - HYPH cord-023095-4dannjjm 3450 6 time time NN cord-023095-4dannjjm 3450 7 PCR PCR NNP cord-023095-4dannjjm 3450 8 ( ( -LRB- cord-023095-4dannjjm 3450 9 RT RT NNP cord-023095-4dannjjm 3450 10 PCR PCR NNP cord-023095-4dannjjm 3450 11 ) ) -RRB- cord-023095-4dannjjm 3450 12 assay assay NN cord-023095-4dannjjm 3450 13 consists consist VBZ cord-023095-4dannjjm 3450 14 of of IN cord-023095-4dannjjm 3450 15 four four CD cord-023095-4dannjjm 3450 16 multiplexed multiplexed JJ cord-023095-4dannjjm 3450 17 primer primer NN cord-023095-4dannjjm 3450 18 systems system NNS cord-023095-4dannjjm 3450 19 designed design VBN cord-023095-4dannjjm 3450 20 to to TO cord-023095-4dannjjm 3450 21 detect detect VB cord-023095-4dannjjm 3450 22 a a DT cord-023095-4dannjjm 3450 23 total total NN cord-023095-4dannjjm 3450 24 of of IN cord-023095-4dannjjm 3450 25 three three CD cord-023095-4dannjjm 3450 26 distinct distinct JJ cord-023095-4dannjjm 3450 27 genes gene NNS cord-023095-4dannjjm 3450 28 . . . cord-023095-4dannjjm 3451 1 Amplicons Amplicons NNP cord-023095-4dannjjm 3451 2 were be VBD cord-023095-4dannjjm 3451 3 confirmed confirm VBN cord-023095-4dannjjm 3451 4 as as IN cord-023095-4dannjjm 3451 5 A. a. NN cord-023095-4dannjjm 3451 6 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3451 7 by by IN cord-023095-4dannjjm 3451 8 DNA dna NN cord-023095-4dannjjm 3451 9 sequencing sequencing NN cord-023095-4dannjjm 3451 10 . . . cord-023095-4dannjjm 3452 1 Clinicopathologic Clinicopathologic NNP cord-023095-4dannjjm 3452 2 data datum NNS cord-023095-4dannjjm 3452 3 was be VBD cord-023095-4dannjjm 3452 4 obtained obtain VBN cord-023095-4dannjjm 3452 5 by by IN cord-023095-4dannjjm 3452 6 review review NN cord-023095-4dannjjm 3452 7 of of IN cord-023095-4dannjjm 3452 8 medical medical JJ cord-023095-4dannjjm 3452 9 records record NNS cord-023095-4dannjjm 3452 10 and and CC cord-023095-4dannjjm 3452 11 interview interview NN cord-023095-4dannjjm 3452 12 of of IN cord-023095-4dannjjm 3452 13 primary primary JJ cord-023095-4dannjjm 3452 14 veterinarians veterinarian NNS cord-023095-4dannjjm 3452 15 . . . cord-023095-4dannjjm 3453 1 Complete complete JJ cord-023095-4dannjjm 3453 2 blood blood NN cord-023095-4dannjjm 3453 3 counts count NNS cord-023095-4dannjjm 3453 4 were be VBD cord-023095-4dannjjm 3453 5 available available JJ cord-023095-4dannjjm 3453 6 from from IN cord-023095-4dannjjm 3453 7 13/15 13/15 CD cord-023095-4dannjjm 3453 8 cats cat NNS cord-023095-4dannjjm 3453 9 and and CC cord-023095-4dannjjm 3453 10 10/13 10/13 CD cord-023095-4dannjjm 3453 11 blood blood NN cord-023095-4dannjjm 3453 12 smears smear NNS cord-023095-4dannjjm 3453 13 were be VBD cord-023095-4dannjjm 3453 14 reviewed review VBN cord-023095-4dannjjm 3453 15 . . . cord-023095-4dannjjm 3454 1 The the DT cord-023095-4dannjjm 3454 2 cats cat NNS cord-023095-4dannjjm 3454 3 included include VBD cord-023095-4dannjjm 3454 4 in in IN cord-023095-4dannjjm 3454 5 this this DT cord-023095-4dannjjm 3454 6 study study NN cord-023095-4dannjjm 3454 7 were be VBD cord-023095-4dannjjm 3454 8 all all DT cord-023095-4dannjjm 3454 9 positive positive JJ cord-023095-4dannjjm 3454 10 for for IN cord-023095-4dannjjm 3454 11 A. a. NN cord-023095-4dannjjm 3454 12 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3454 13 by by IN cord-023095-4dannjjm 3454 14 real real JJ cord-023095-4dannjjm 3454 15 - - HYPH cord-023095-4dannjjm 3454 16 time time NN cord-023095-4dannjjm 3454 17 PCR PCR NNP cord-023095-4dannjjm 3454 18 . . . cord-023095-4dannjjm 3455 1 The the DT cord-023095-4dannjjm 3455 2 cats cat NNS cord-023095-4dannjjm 3455 3 ranged range VBD cord-023095-4dannjjm 3455 4 from from IN cord-023095-4dannjjm 3455 5 4 4 CD cord-023095-4dannjjm 3455 6 months month NNS cord-023095-4dannjjm 3455 7 to to IN cord-023095-4dannjjm 3455 8 13 13 CD cord-023095-4dannjjm 3455 9 years year NNS cord-023095-4dannjjm 3455 10 of of IN cord-023095-4dannjjm 3455 11 age age NN cord-023095-4dannjjm 3455 12 with with IN cord-023095-4dannjjm 3455 13 an an DT cord-023095-4dannjjm 3455 14 average average JJ cord-023095-4dannjjm 3455 15 age age NN cord-023095-4dannjjm 3455 16 of of IN cord-023095-4dannjjm 3455 17 3.7 3.7 CD cord-023095-4dannjjm 3455 18 years year NNS cord-023095-4dannjjm 3455 19 . . . cord-023095-4dannjjm 3456 1 Fifteen fifteen CD cord-023095-4dannjjm 3456 2 of of IN cord-023095-4dannjjm 3456 3 15 15 CD cord-023095-4dannjjm 3456 4 cats cat NNS cord-023095-4dannjjm 3456 5 had have VBD cord-023095-4dannjjm 3456 6 a a DT cord-023095-4dannjjm 3456 7 history history NN cord-023095-4dannjjm 3456 8 of of IN cord-023095-4dannjjm 3456 9 tick tick NN cord-023095-4dannjjm 3456 10 exposure exposure NN cord-023095-4dannjjm 3456 11 and and CC cord-023095-4dannjjm 3456 12 lived live VBD cord-023095-4dannjjm 3456 13 in in IN cord-023095-4dannjjm 3456 14 the the DT cord-023095-4dannjjm 3456 15 northeastern northeastern JJ cord-023095-4dannjjm 3456 16 region region NN cord-023095-4dannjjm 3456 17 of of IN cord-023095-4dannjjm 3456 18 the the DT cord-023095-4dannjjm 3456 19 US US NNP cord-023095-4dannjjm 3456 20 , , , cord-023095-4dannjjm 3456 21 an an DT cord-023095-4dannjjm 3456 22 Ixodes Ixodes NNP cord-023095-4dannjjm 3456 23 endemic endemic JJ cord-023095-4dannjjm 3456 24 area area NN cord-023095-4dannjjm 3456 25 . . . cord-023095-4dannjjm 3457 1 All all DT cord-023095-4dannjjm 3457 2 cats cat NNS cord-023095-4dannjjm 3457 3 presented present VBN cord-023095-4dannjjm 3457 4 with with IN cord-023095-4dannjjm 3457 5 lethargy lethargy NN cord-023095-4dannjjm 3457 6 , , , cord-023095-4dannjjm 3457 7 13/15 13/15 CD cord-023095-4dannjjm 3457 8 were be VBD cord-023095-4dannjjm 3457 9 anorexic anorexic JJ cord-023095-4dannjjm 3457 10 and and CC cord-023095-4dannjjm 3457 11 14/15 14/15 CD cord-023095-4dannjjm 3457 12 had have VBD cord-023095-4dannjjm 3457 13 a a DT cord-023095-4dannjjm 3457 14 fever fever NN cord-023095-4dannjjm 3457 15 ( ( -LRB- cord-023095-4dannjjm 3457 16 temperature temperature NN cord-023095-4dannjjm 3457 17 4 4 CD cord-023095-4dannjjm 3457 18 103 103 CD cord-023095-4dannjjm 3457 19 o o NN cord-023095-4dannjjm 3457 20 F f NN cord-023095-4dannjjm 3457 21 ) ) -RRB- cord-023095-4dannjjm 3457 22 . . . cord-023095-4dannjjm 3458 1 Other other JJ cord-023095-4dannjjm 3458 2 clinical clinical JJ cord-023095-4dannjjm 3458 3 findings finding NNS cord-023095-4dannjjm 3458 4 included include VBD cord-023095-4dannjjm 3458 5 hepatomegaly hepatomegaly NNP cord-023095-4dannjjm 3458 6 , , , cord-023095-4dannjjm 3458 7 splenomegaly splenomegaly NN cord-023095-4dannjjm 3458 8 , , , cord-023095-4dannjjm 3458 9 ataxia ataxia NN cord-023095-4dannjjm 3458 10 and and CC cord-023095-4dannjjm 3458 11 ocular ocular JJ cord-023095-4dannjjm 3458 12 changes change NNS cord-023095-4dannjjm 3458 13 of of IN cord-023095-4dannjjm 3458 14 conjunctivitis conjunctivitis NN cord-023095-4dannjjm 3458 15 and and CC cord-023095-4dannjjm 3458 16 elevation elevation NN cord-023095-4dannjjm 3458 17 of of IN cord-023095-4dannjjm 3458 18 the the DT cord-023095-4dannjjm 3458 19 nictitating nictitate VBG cord-023095-4dannjjm 3458 20 membrane membrane NN cord-023095-4dannjjm 3458 21 . . . cord-023095-4dannjjm 3459 1 Hematologic Hematologic NNP cord-023095-4dannjjm 3459 2 findings finding NNS cord-023095-4dannjjm 3459 3 included include VBD cord-023095-4dannjjm 3459 4 leukopenia leukopenia NN cord-023095-4dannjjm 3459 5 ( ( -LRB- cord-023095-4dannjjm 3459 6 1/13 1/13 CD cord-023095-4dannjjm 3459 7 ) ) -RRB- cord-023095-4dannjjm 3459 8 , , , cord-023095-4dannjjm 3459 9 neutropenia neutropenia FW cord-023095-4dannjjm 3459 10 ( ( -LRB- cord-023095-4dannjjm 3459 11 1/13 1/13 CD cord-023095-4dannjjm 3459 12 ) ) -RRB- cord-023095-4dannjjm 3459 13 and and CC cord-023095-4dannjjm 3459 14 lymphopenia lymphopenia NNP cord-023095-4dannjjm 3459 15 ( ( -LRB- cord-023095-4dannjjm 3459 16 4/13 4/13 CD cord-023095-4dannjjm 3459 17 ) ) -RRB- cord-023095-4dannjjm 3459 18 . . . cord-023095-4dannjjm 3460 1 Thrombocytopenia Thrombocytopenia NNP cord-023095-4dannjjm 3460 2 was be VBD cord-023095-4dannjjm 3460 3 not not RB cord-023095-4dannjjm 3460 4 noted note VBN cord-023095-4dannjjm 3460 5 in in IN cord-023095-4dannjjm 3460 6 any any DT cord-023095-4dannjjm 3460 7 case case NN cord-023095-4dannjjm 3460 8 . . . cord-023095-4dannjjm 3461 1 Morulae Morulae NNP cord-023095-4dannjjm 3461 2 were be VBD cord-023095-4dannjjm 3461 3 seen see VBN cord-023095-4dannjjm 3461 4 within within IN cord-023095-4dannjjm 3461 5 neutrophils neutrophil NNS cord-023095-4dannjjm 3461 6 in in IN cord-023095-4dannjjm 3461 7 2/13 2/13 CD cord-023095-4dannjjm 3461 8 cases case NNS cord-023095-4dannjjm 3461 9 . . . cord-023095-4dannjjm 3462 1 All all DT cord-023095-4dannjjm 3462 2 cases case NNS cord-023095-4dannjjm 3462 3 in in IN cord-023095-4dannjjm 3462 4 this this DT cord-023095-4dannjjm 3462 5 report report NN cord-023095-4dannjjm 3462 6 responded respond VBD cord-023095-4dannjjm 3462 7 to to IN cord-023095-4dannjjm 3462 8 treatment treatment NN cord-023095-4dannjjm 3462 9 with with IN cord-023095-4dannjjm 3462 10 doxycycline doxycycline NNP cord-023095-4dannjjm 3462 11 . . . cord-023095-4dannjjm 3463 1 This this DT cord-023095-4dannjjm 3463 2 is be VBZ cord-023095-4dannjjm 3463 3 the the DT cord-023095-4dannjjm 3463 4 first first JJ cord-023095-4dannjjm 3463 5 report report NN cord-023095-4dannjjm 3463 6 of of IN cord-023095-4dannjjm 3463 7 the the DT cord-023095-4dannjjm 3463 8 identification identification NN cord-023095-4dannjjm 3463 9 of of IN cord-023095-4dannjjm 3463 10 morulae morulae NNP cord-023095-4dannjjm 3463 11 within within IN cord-023095-4dannjjm 3463 12 neutrophils neutrophil NNS cord-023095-4dannjjm 3463 13 via via IN cord-023095-4dannjjm 3463 14 peripheral peripheral JJ cord-023095-4dannjjm 3463 15 blood blood NN cord-023095-4dannjjm 3463 16 smear smear NN cord-023095-4dannjjm 3463 17 review review NN cord-023095-4dannjjm 3463 18 in in IN cord-023095-4dannjjm 3463 19 cats cat NNS cord-023095-4dannjjm 3463 20 confirmed confirm VBN cord-023095-4dannjjm 3463 21 by by IN cord-023095-4dannjjm 3463 22 RT RT NNP cord-023095-4dannjjm 3463 23 PCR PCR NNP cord-023095-4dannjjm 3463 24 to to TO cord-023095-4dannjjm 3463 25 be be VB cord-023095-4dannjjm 3463 26 infected infect VBN cord-023095-4dannjjm 3463 27 with with IN cord-023095-4dannjjm 3463 28 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3463 29 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3463 30 in in IN cord-023095-4dannjjm 3463 31 North North NNP cord-023095-4dannjjm 3463 32 America America NNP cord-023095-4dannjjm 3463 33 . . . cord-023095-4dannjjm 3464 1 Infection infection NN cord-023095-4dannjjm 3464 2 with with IN cord-023095-4dannjjm 3464 3 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3464 4 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3464 5 should should MD cord-023095-4dannjjm 3464 6 be be VB cord-023095-4dannjjm 3464 7 considered consider VBN cord-023095-4dannjjm 3464 8 in in IN cord-023095-4dannjjm 3464 9 a a DT cord-023095-4dannjjm 3464 10 clinically clinically RB cord-023095-4dannjjm 3464 11 ill ill JJ cord-023095-4dannjjm 3464 12 cat cat NN cord-023095-4dannjjm 3464 13 with with IN cord-023095-4dannjjm 3464 14 tick tick NN cord-023095-4dannjjm 3464 15 exposure exposure NN cord-023095-4dannjjm 3464 16 , , , cord-023095-4dannjjm 3464 17 living live VBG cord-023095-4dannjjm 3464 18 in in IN cord-023095-4dannjjm 3464 19 an an DT cord-023095-4dannjjm 3464 20 Ixodes Ixodes NNP cord-023095-4dannjjm 3464 21 endemic endemic JJ cord-023095-4dannjjm 3464 22 area area NN cord-023095-4dannjjm 3464 23 that that WDT cord-023095-4dannjjm 3464 24 presents present VBZ cord-023095-4dannjjm 3464 25 to to IN cord-023095-4dannjjm 3464 26 a a DT cord-023095-4dannjjm 3464 27 veterinarian veterinarian NN cord-023095-4dannjjm 3464 28 for for IN cord-023095-4dannjjm 3464 29 lethargy lethargy NN cord-023095-4dannjjm 3464 30 , , , cord-023095-4dannjjm 3464 31 anorexia anorexia NN cord-023095-4dannjjm 3464 32 and and CC cord-023095-4dannjjm 3464 33 fever fever NN cord-023095-4dannjjm 3464 34 . . . cord-023095-4dannjjm 3465 1 The the DT cord-023095-4dannjjm 3465 2 spectrum spectrum NN cord-023095-4dannjjm 3465 3 of of IN cord-023095-4dannjjm 3465 4 disease disease NN cord-023095-4dannjjm 3465 5 manifestations manifestation NNS cord-023095-4dannjjm 3465 6 and and CC cord-023095-4dannjjm 3465 7 the the DT cord-023095-4dannjjm 3465 8 accompanying accompany VBG cord-023095-4dannjjm 3465 9 clinicopathological clinicopathological NN cord-023095-4dannjjm 3465 10 abnormalities abnormality NNS cord-023095-4dannjjm 3465 11 indicative indicative JJ cord-023095-4dannjjm 3465 12 of of IN cord-023095-4dannjjm 3465 13 bartonellosis bartonellosis NN cord-023095-4dannjjm 3465 14 in in IN cord-023095-4dannjjm 3465 15 dogs dog NNS cord-023095-4dannjjm 3465 16 have have VBP cord-023095-4dannjjm 3465 17 not not RB cord-023095-4dannjjm 3465 18 been be VBN cord-023095-4dannjjm 3465 19 thoroughly thoroughly RB cord-023095-4dannjjm 3465 20 characterized characterize VBN cord-023095-4dannjjm 3465 21 . . . cord-023095-4dannjjm 3466 1 The the DT cord-023095-4dannjjm 3466 2 objective objective NN cord-023095-4dannjjm 3466 3 of of IN cord-023095-4dannjjm 3466 4 this this DT cord-023095-4dannjjm 3466 5 unmatched unmatched JJ cord-023095-4dannjjm 3466 6 case case NN cord-023095-4dannjjm 3466 7 - - HYPH cord-023095-4dannjjm 3466 8 control control NN cord-023095-4dannjjm 3466 9 study study NN cord-023095-4dannjjm 3466 10 was be VBD cord-023095-4dannjjm 3466 11 to to TO cord-023095-4dannjjm 3466 12 compare compare VB cord-023095-4dannjjm 3466 13 signalment signalment JJ cord-023095-4dannjjm 3466 14 , , , cord-023095-4dannjjm 3466 15 clinical clinical JJ cord-023095-4dannjjm 3466 16 and and CC cord-023095-4dannjjm 3466 17 pathologic pathologic JJ cord-023095-4dannjjm 3466 18 findings finding NNS cord-023095-4dannjjm 3466 19 in in IN cord-023095-4dannjjm 3466 20 clinically clinically RB cord-023095-4dannjjm 3466 21 - - HYPH cord-023095-4dannjjm 3466 22 ill ill JJ cord-023095-4dannjjm 3466 23 dogs dog NNS cord-023095-4dannjjm 3466 24 suspected suspect VBN cord-023095-4dannjjm 3466 25 of of IN cord-023095-4dannjjm 3466 26 a a DT cord-023095-4dannjjm 3466 27 tick tick VB cord-023095-4dannjjm 3466 28 - - HYPH cord-023095-4dannjjm 3466 29 borne bear VBN cord-023095-4dannjjm 3466 30 disease disease NN cord-023095-4dannjjm 3466 31 that that WDT cord-023095-4dannjjm 3466 32 were be VBD cord-023095-4dannjjm 3466 33 negative negative JJ cord-023095-4dannjjm 3466 34 for for IN cord-023095-4dannjjm 3466 35 Bartonella Bartonella NNP cord-023095-4dannjjm 3466 36 sp sp NN cord-023095-4dannjjm 3466 37 . . . cord-023095-4dannjjm 3467 1 DNA DNA NNP cord-023095-4dannjjm 3467 2 ( ( -LRB- cord-023095-4dannjjm 3467 3 controls control NNS cord-023095-4dannjjm 3467 4 ) ) -RRB- cord-023095-4dannjjm 3467 5 as as IN cord-023095-4dannjjm 3467 6 were be VBD cord-023095-4dannjjm 3467 7 the the DT cord-023095-4dannjjm 3467 8 dogs dog NNS cord-023095-4dannjjm 3467 9 diagnosed diagnose VBN cord-023095-4dannjjm 3467 10 with with IN cord-023095-4dannjjm 3467 11 bartonellosis bartonellosis NN cord-023095-4dannjjm 3467 12 by by IN cord-023095-4dannjjm 3467 13 PCR PCR NNP cord-023095-4dannjjm 3467 14 amplification amplification NN cord-023095-4dannjjm 3467 15 , , , cord-023095-4dannjjm 3467 16 DNA dna NN cord-023095-4dannjjm 3467 17 sequencing sequencing NN cord-023095-4dannjjm 3467 18 and and CC cord-023095-4dannjjm 3467 19 the the DT cord-023095-4dannjjm 3467 20 BAPGM BAPGM NNP cord-023095-4dannjjm 3467 21 ( ( -LRB- cord-023095-4dannjjm 3467 22 Bartonella Bartonella NNP cord-023095-4dannjjm 3467 23 alpha alpha NN cord-023095-4dannjjm 3467 24 Proteobacteria Proteobacteria NNP cord-023095-4dannjjm 3467 25 growth growth NN cord-023095-4dannjjm 3467 26 medium medium NN cord-023095-4dannjjm 3467 27 ) ) -RRB- cord-023095-4dannjjm 3467 28 enrichment enrichment NN cord-023095-4dannjjm 3467 29 culture culture NN cord-023095-4dannjjm 3467 30 approach approach NN cord-023095-4dannjjm 3467 31 . . . cord-023095-4dannjjm 3468 1 Both both DT cord-023095-4dannjjm 3468 2 groups group NNS cord-023095-4dannjjm 3468 3 were be VBD cord-023095-4dannjjm 3468 4 tested test VBN cord-023095-4dannjjm 3468 5 under under IN cord-023095-4dannjjm 3468 6 the the DT cord-023095-4dannjjm 3468 7 same same JJ cord-023095-4dannjjm 3468 8 laboratory laboratory NN cord-023095-4dannjjm 3468 9 conditions condition NNS cord-023095-4dannjjm 3468 10 and and CC cord-023095-4dannjjm 3468 11 in in IN cord-023095-4dannjjm 3468 12 the the DT cord-023095-4dannjjm 3468 13 same same JJ cord-023095-4dannjjm 3468 14 time time NN cord-023095-4dannjjm 3468 15 frame frame NN cord-023095-4dannjjm 3468 16 . . . cord-023095-4dannjjm 3469 1 Medical medical JJ cord-023095-4dannjjm 3469 2 records record NNS cord-023095-4dannjjm 3469 3 were be VBD cord-023095-4dannjjm 3469 4 reviewed review VBN cord-023095-4dannjjm 3469 5 for for IN cord-023095-4dannjjm 3469 6 information information NN cord-023095-4dannjjm 3469 7 regarding regard VBG cord-023095-4dannjjm 3469 8 signalment signalment JJ cord-023095-4dannjjm 3469 9 , , , cord-023095-4dannjjm 3469 10 medical medical JJ cord-023095-4dannjjm 3469 11 history history NN cord-023095-4dannjjm 3469 12 , , , cord-023095-4dannjjm 3469 13 physical physical JJ cord-023095-4dannjjm 3469 14 examination examination NN cord-023095-4dannjjm 3469 15 findings finding NNS cord-023095-4dannjjm 3469 16 , , , cord-023095-4dannjjm 3469 17 clinicopathological clinicopathological JJ cord-023095-4dannjjm 3469 18 abnormalities abnormality NNS cord-023095-4dannjjm 3469 19 , , , cord-023095-4dannjjm 3469 20 microbiological microbiological JJ cord-023095-4dannjjm 3469 21 data datum NNS cord-023095-4dannjjm 3469 22 and and CC cord-023095-4dannjjm 3469 23 treatment treatment NN cord-023095-4dannjjm 3469 24 . . . cord-023095-4dannjjm 3470 1 The the DT cord-023095-4dannjjm 3470 2 study study NN cord-023095-4dannjjm 3470 3 population population NN cord-023095-4dannjjm 3470 4 consisted consist VBD cord-023095-4dannjjm 3470 5 of of IN cord-023095-4dannjjm 3470 6 47 47 CD cord-023095-4dannjjm 3470 7 Bartonella Bartonella NNP cord-023095-4dannjjm 3470 8 - - HYPH cord-023095-4dannjjm 3470 9 infected infect VBN cord-023095-4dannjjm 3470 10 dogs dog NNS cord-023095-4dannjjm 3470 11 and and CC cord-023095-4dannjjm 3470 12 93 93 CD cord-023095-4dannjjm 3470 13 non non JJ cord-023095-4dannjjm 3470 14 - - JJ cord-023095-4dannjjm 3470 15 infected infected JJ cord-023095-4dannjjm 3470 16 dogs dog NNS cord-023095-4dannjjm 3470 17 . . . cord-023095-4dannjjm 3471 1 Healthy healthy JJ cord-023095-4dannjjm 3471 2 dogs dog NNS cord-023095-4dannjjm 3471 3 with with IN cord-023095-4dannjjm 3471 4 no no DT cord-023095-4dannjjm 3471 5 historical historical JJ cord-023095-4dannjjm 3471 6 illnesses illness NNS cord-023095-4dannjjm 3471 7 , , , cord-023095-4dannjjm 3471 8 such such JJ cord-023095-4dannjjm 3471 9 as as IN cord-023095-4dannjjm 3471 10 blood blood NN cord-023095-4dannjjm 3471 11 donors donor NNS cord-023095-4dannjjm 3471 12 , , , cord-023095-4dannjjm 3471 13 were be VBD cord-023095-4dannjjm 3471 14 excluded exclude VBN cord-023095-4dannjjm 3471 15 . . . cord-023095-4dannjjm 3472 1 The the DT cord-023095-4dannjjm 3472 2 following follow VBG cord-023095-4dannjjm 3472 3 species specie NNS cord-023095-4dannjjm 3472 4 were be VBD cord-023095-4dannjjm 3472 5 amplified amplify VBN cord-023095-4dannjjm 3472 6 : : : cord-023095-4dannjjm 3472 7 B. B. NNP cord-023095-4dannjjm 3472 8 henselae henselae NNP cord-023095-4dannjjm 3472 9 ( ( -LRB- cord-023095-4dannjjm 3472 10 n n NN cord-023095-4dannjjm 3472 11 5 5 CD cord-023095-4dannjjm 3472 12 28 28 CD cord-023095-4dannjjm 3472 13 , , , cord-023095-4dannjjm 3472 14 59.6 59.6 CD cord-023095-4dannjjm 3472 15 % % NN cord-023095-4dannjjm 3472 16 ) ) -RRB- cord-023095-4dannjjm 3472 17 , , , cord-023095-4dannjjm 3472 18 B. B. NNP cord-023095-4dannjjm 3472 19 vinsonii vinsonii NNP cord-023095-4dannjjm 3472 20 subsp subsp NNP cord-023095-4dannjjm 3472 21 . . . cord-023095-4dannjjm 3473 1 berkhoffii berkhoffii NNP cord-023095-4dannjjm 3473 2 ( ( -LRB- cord-023095-4dannjjm 3473 3 n n NN cord-023095-4dannjjm 3473 4 5 5 CD cord-023095-4dannjjm 3473 5 20 20 CD cord-023095-4dannjjm 3473 6 , , , cord-023095-4dannjjm 3473 7 42.6 42.6 CD cord-023095-4dannjjm 3473 8 % % NN cord-023095-4dannjjm 3473 9 ) ) -RRB- cord-023095-4dannjjm 3473 10 , , , cord-023095-4dannjjm 3473 11 B. B. NNP cord-023095-4dannjjm 3473 12 koehlerae koehlerae NNP cord-023095-4dannjjm 3473 13 ( ( -LRB- cord-023095-4dannjjm 3473 14 n n NN cord-023095-4dannjjm 3473 15 5 5 CD cord-023095-4dannjjm 3473 16 3 3 CD cord-023095-4dannjjm 3473 17 , , , cord-023095-4dannjjm 3473 18 6.4 6.4 CD cord-023095-4dannjjm 3473 19 % % NN cord-023095-4dannjjm 3473 20 ) ) -RRB- cord-023095-4dannjjm 3473 21 , , , cord-023095-4dannjjm 3473 22 B. B. NNP cord-023095-4dannjjm 3473 23 volans volans NNP cord-023095-4dannjjm 3473 24 - - HYPH cord-023095-4dannjjm 3473 25 like like JJ cord-023095-4dannjjm 3473 26 ( ( -LRB- cord-023095-4dannjjm 3473 27 n n NN cord-023095-4dannjjm 3473 28 5 5 CD cord-023095-4dannjjm 3473 29 3 3 CD cord-023095-4dannjjm 3473 30 , , , cord-023095-4dannjjm 3473 31 6.4 6.4 CD cord-023095-4dannjjm 3473 32 % % NN cord-023095-4dannjjm 3473 33 ) ) -RRB- cord-023095-4dannjjm 3473 34 , , , cord-023095-4dannjjm 3473 35 B. B. NNP cord-023095-4dannjjm 3473 36 bovis bovis NNP cord-023095-4dannjjm 3473 37 ( ( -LRB- cord-023095-4dannjjm 3473 38 n n NN cord-023095-4dannjjm 3473 39 5 5 CD cord-023095-4dannjjm 3473 40 1 1 CD cord-023095-4dannjjm 3473 41 , , , cord-023095-4dannjjm 3473 42 2.1 2.1 CD cord-023095-4dannjjm 3473 43 % % NN cord-023095-4dannjjm 3473 44 ) ) -RRB- cord-023095-4dannjjm 3473 45 . . . cord-023095-4dannjjm 3474 1 Nineteen nineteen CD cord-023095-4dannjjm 3474 2 ( ( -LRB- cord-023095-4dannjjm 3474 3 40.4 40.4 CD cord-023095-4dannjjm 3474 4 % % NN cord-023095-4dannjjm 3474 5 ) ) -RRB- cord-023095-4dannjjm 3475 1 Bartonella bartonella NN cord-023095-4dannjjm 3475 2 - - HYPH cord-023095-4dannjjm 3475 3 infected infect VBN cord-023095-4dannjjm 3475 4 dogs dog NNS cord-023095-4dannjjm 3475 5 were be VBD cord-023095-4dannjjm 3475 6 febrile febrile JJ cord-023095-4dannjjm 3475 7 and and CC cord-023095-4dannjjm 3475 8 lethargic lethargic JJ cord-023095-4dannjjm 3475 9 and and CC cord-023095-4dannjjm 3475 10 ten ten JJ cord-023095-4dannjjm 3475 11 ( ( -LRB- cord-023095-4dannjjm 3475 12 21.3 21.3 CD cord-023095-4dannjjm 3475 13 % % NN cord-023095-4dannjjm 3475 14 ) ) -RRB- cord-023095-4dannjjm 3475 15 had have VBD cord-023095-4dannjjm 3475 16 neurological neurological JJ cord-023095-4dannjjm 3475 17 signs sign NNS cord-023095-4dannjjm 3475 18 . . . cord-023095-4dannjjm 3476 1 Laboratory laboratory NN cord-023095-4dannjjm 3476 2 abnormalities abnormality NNS cord-023095-4dannjjm 3476 3 for for IN cord-023095-4dannjjm 3476 4 both both DT cord-023095-4dannjjm 3476 5 groups group NNS cord-023095-4dannjjm 3476 6 are be VBP cord-023095-4dannjjm 3476 7 summarized summarize VBN cord-023095-4dannjjm 3476 8 below below IN cord-023095-4dannjjm 3476 9 ( ( -LRB- cord-023095-4dannjjm 3476 10 number number NN cord-023095-4dannjjm 3476 11 of of IN cord-023095-4dannjjm 3476 12 affected affect VBN cord-023095-4dannjjm 3476 13 dogs dog NNS cord-023095-4dannjjm 3476 14 provided provide VBN cord-023095-4dannjjm 3476 15 in in IN cord-023095-4dannjjm 3476 16 parenthesis parenthesis NN cord-023095-4dannjjm 3476 17 ) ) -RRB- cord-023095-4dannjjm 3476 18 : : : cord-023095-4dannjjm 3476 19 Multivariate multivariate JJ cord-023095-4dannjjm 3476 20 logistic logistic JJ cord-023095-4dannjjm 3476 21 regression regression NN cord-023095-4dannjjm 3476 22 using use VBG cord-023095-4dannjjm 3476 23 confounding confounding JJ cord-023095-4dannjjm 3476 24 factors factor NNS cord-023095-4dannjjm 3476 25 was be VBD cord-023095-4dannjjm 3476 26 performed perform VBN cord-023095-4dannjjm 3476 27 to to TO cord-023095-4dannjjm 3476 28 establish establish VB cord-023095-4dannjjm 3476 29 potential potential JJ cord-023095-4dannjjm 3476 30 associations association NNS cord-023095-4dannjjm 3476 31 between between IN cord-023095-4dannjjm 3476 32 specific specific JJ cord-023095-4dannjjm 3476 33 variables variable NNS cord-023095-4dannjjm 3476 34 and and CC cord-023095-4dannjjm 3476 35 Bartonella Bartonella NNP cord-023095-4dannjjm 3476 36 sp sp NN cord-023095-4dannjjm 3476 37 . . . cord-023095-4dannjjm 3476 38 infection infection NN cord-023095-4dannjjm 3476 39 . . . cord-023095-4dannjjm 3477 1 There there EX cord-023095-4dannjjm 3477 2 were be VBD cord-023095-4dannjjm 3477 3 no no DT cord-023095-4dannjjm 3477 4 differences difference NNS cord-023095-4dannjjm 3477 5 in in IN cord-023095-4dannjjm 3477 6 signalment signalment JJ cord-023095-4dannjjm 3477 7 , , , cord-023095-4dannjjm 3477 8 age age NN cord-023095-4dannjjm 3477 9 , , , cord-023095-4dannjjm 3477 10 sex sex NN cord-023095-4dannjjm 3477 11 , , , cord-023095-4dannjjm 3477 12 body body NN cord-023095-4dannjjm 3477 13 weight weight NN cord-023095-4dannjjm 3477 14 and and CC cord-023095-4dannjjm 3477 15 duration duration NN cord-023095-4dannjjm 3477 16 of of IN cord-023095-4dannjjm 3477 17 clinical clinical JJ cord-023095-4dannjjm 3477 18 signs sign NNS cord-023095-4dannjjm 3477 19 between between IN cord-023095-4dannjjm 3477 20 the the DT cord-023095-4dannjjm 3477 21 two two CD cord-023095-4dannjjm 3477 22 groups group NNS cord-023095-4dannjjm 3477 23 . . . cord-023095-4dannjjm 3478 1 Compared compare VBN cord-023095-4dannjjm 3478 2 to to IN cord-023095-4dannjjm 3478 3 the the DT cord-023095-4dannjjm 3478 4 control control NN cord-023095-4dannjjm 3478 5 population population NN cord-023095-4dannjjm 3478 6 , , , cord-023095-4dannjjm 3478 7 infection infection NN cord-023095-4dannjjm 3478 8 with with IN cord-023095-4dannjjm 3478 9 the the DT cord-023095-4dannjjm 3478 10 genus genus NN cord-023095-4dannjjm 3478 11 Bartonella Bartonella NNP cord-023095-4dannjjm 3478 12 was be VBD cord-023095-4dannjjm 3478 13 associated associate VBN cord-023095-4dannjjm 3478 14 with with IN cord-023095-4dannjjm 3478 15 a a DT cord-023095-4dannjjm 3478 16 diagnosis diagnosis NN cord-023095-4dannjjm 3478 17 of of IN cord-023095-4dannjjm 3478 18 endocarditis endocarditis NN cord-023095-4dannjjm 3478 19 ( ( -LRB- cord-023095-4dannjjm 3478 20 P p NN cord-023095-4dannjjm 3478 21 5 5 CD cord-023095-4dannjjm 3478 22 0.0196 0.0196 CD cord-023095-4dannjjm 3478 23 , , , cord-023095-4dannjjm 3478 24 OR or CC cord-023095-4dannjjm 3478 25 5 5 CD cord-023095-4dannjjm 3478 26 7.95 7.95 CD cord-023095-4dannjjm 3478 27 , , , cord-023095-4dannjjm 3478 28 95%CI 95%ci CD cord-023095-4dannjjm 3478 29 5 5 CD cord-023095-4dannjjm 3478 30 1.39 1.39 CD cord-023095-4dannjjm 3478 31 - - HYPH cord-023095-4dannjjm 3478 32 51.11 51.11 CD cord-023095-4dannjjm 3478 33 ) ) -RRB- cord-023095-4dannjjm 3478 34 and and CC cord-023095-4dannjjm 3478 35 hypoglobulinemia hypoglobulinemia NNP cord-023095-4dannjjm 3478 36 ( ( -LRB- cord-023095-4dannjjm 3478 37 P p NN cord-023095-4dannjjm 3478 38 5 5 CD cord-023095-4dannjjm 3478 39 0.0057 0.0057 CD cord-023095-4dannjjm 3478 40 , , , cord-023095-4dannjjm 3478 41 OR or CC cord-023095-4dannjjm 3478 42 5 5 CD cord-023095-4dannjjm 3478 43 5.30 5.30 CD cord-023095-4dannjjm 3479 1 , , , cord-023095-4dannjjm 3479 2 95 95 CD cord-023095-4dannjjm 3479 3 % % NN cord-023095-4dannjjm 3479 4 CI CI NNP cord-023095-4dannjjm 3479 5 5 5 CD cord-023095-4dannjjm 3479 6 1.62 1.62 CD cord-023095-4dannjjm 3479 7 - - HYPH cord-023095-4dannjjm 3479 8 18.55 18.55 CD cord-023095-4dannjjm 3479 9 ) ) -RRB- cord-023095-4dannjjm 3479 10 . . . cord-023095-4dannjjm 3480 1 Controls control NNS cord-023095-4dannjjm 3480 2 were be VBD cord-023095-4dannjjm 3480 3 more more RBR cord-023095-4dannjjm 3480 4 likely likely JJ cord-023095-4dannjjm 3480 5 to to TO cord-023095-4dannjjm 3480 6 have have VB cord-023095-4dannjjm 3480 7 joint joint JJ cord-023095-4dannjjm 3480 8 effusion effusion NN cord-023095-4dannjjm 3480 9 ( ( -LRB- cord-023095-4dannjjm 3480 10 P p NN cord-023095-4dannjjm 3480 11 5 5 CD cord-023095-4dannjjm 3480 12 0.0059 0.0059 CD cord-023095-4dannjjm 3480 13 , , , cord-023095-4dannjjm 3480 14 OR or CC cord-023095-4dannjjm 3480 15 5 5 CD cord-023095-4dannjjm 3480 16 5.89 5.89 CD cord-023095-4dannjjm 3480 17 , , , cord-023095-4dannjjm 3480 18 95 95 CD cord-023095-4dannjjm 3480 19 % % NN cord-023095-4dannjjm 3480 20 CI CI NNP cord-023095-4dannjjm 3480 21 5 5 CD cord-023095-4dannjjm 3480 22 1.62 1.62 CD cord-023095-4dannjjm 3480 23 - - HYPH cord-023095-4dannjjm 3480 24 27.22 27.22 CD cord-023095-4dannjjm 3480 25 ) ) -RRB- cord-023095-4dannjjm 3480 26 and and CC cord-023095-4dannjjm 3480 27 azotemia azotemia NNP cord-023095-4dannjjm 3480 28 ( ( -LRB- cord-023095-4dannjjm 3480 29 P p NN cord-023095-4dannjjm 3480 30 5 5 CD cord-023095-4dannjjm 3480 31 0.0353 0.0353 CD cord-023095-4dannjjm 3480 32 , , , cord-023095-4dannjjm 3480 33 OR or CC cord-023095-4dannjjm 3481 1 5 5 CD cord-023095-4dannjjm 3481 2 2.93 2.93 CD cord-023095-4dannjjm 3481 3 , , , cord-023095-4dannjjm 3482 1 95%CI 95%ci CD cord-023095-4dannjjm 3482 2 5 5 CD cord-023095-4dannjjm 3482 3 1.07 1.07 CD cord-023095-4dannjjm 3482 4 - - HYPH cord-023095-4dannjjm 3482 5 8.86 8.86 CD cord-023095-4dannjjm 3482 6 ) ) -RRB- cord-023095-4dannjjm 3482 7 than than IN cord-023095-4dannjjm 3482 8 were be VBD cord-023095-4dannjjm 3482 9 the the DT cord-023095-4dannjjm 3482 10 Bartonella Bartonella NNP cord-023095-4dannjjm 3482 11 sp sp NN cord-023095-4dannjjm 3482 12 . . . cord-023095-4dannjjm 3483 1 infected infected JJ cord-023095-4dannjjm 3483 2 dogs dog NNS cord-023095-4dannjjm 3483 3 . . . cord-023095-4dannjjm 3484 1 Bartonella Bartonella NNP cord-023095-4dannjjm 3484 2 was be VBD cord-023095-4dannjjm 3484 3 detected detect VBN cord-023095-4dannjjm 3484 4 in in IN cord-023095-4dannjjm 3484 5 dogs dog NNS cord-023095-4dannjjm 3484 6 with with IN cord-023095-4dannjjm 3484 7 signs sign NNS cord-023095-4dannjjm 3484 8 such such JJ cord-023095-4dannjjm 3484 9 as as IN cord-023095-4dannjjm 3484 10 fever fever NN cord-023095-4dannjjm 3484 11 , , , cord-023095-4dannjjm 3484 12 anemia anemia NN cord-023095-4dannjjm 3484 13 , , , cord-023095-4dannjjm 3484 14 thrombocytopenia thrombocytopenia NN cord-023095-4dannjjm 3484 15 , , , cord-023095-4dannjjm 3484 16 hyperglobulinemia hyperglobulinemia NN cord-023095-4dannjjm 3484 17 and and CC cord-023095-4dannjjm 3484 18 proteinuria proteinuria NN cord-023095-4dannjjm 3484 19 that that WDT cord-023095-4dannjjm 3484 20 are be VBP cord-023095-4dannjjm 3484 21 typically typically RB cord-023095-4dannjjm 3484 22 associated associate VBN cord-023095-4dannjjm 3484 23 with with IN cord-023095-4dannjjm 3484 24 tick tick NN cord-023095-4dannjjm 3484 25 - - HYPH cord-023095-4dannjjm 3484 26 borne bear VBN cord-023095-4dannjjm 3484 27 diseases disease NNS cord-023095-4dannjjm 3484 28 . . . cord-023095-4dannjjm 3485 1 When when WRB cord-023095-4dannjjm 3485 2 endocarditis endocarditis NN cord-023095-4dannjjm 3485 3 or or CC cord-023095-4dannjjm 3485 4 hypoglobulinemia hypoglobulinemia NN cord-023095-4dannjjm 3485 5 are be VBP cord-023095-4dannjjm 3485 6 detected detect VBN cord-023095-4dannjjm 3485 7 , , , cord-023095-4dannjjm 3485 8 testing test VBG cord-023095-4dannjjm 3485 9 for for IN cord-023095-4dannjjm 3485 10 Bartonella Bartonella NNP cord-023095-4dannjjm 3485 11 should should MD cord-023095-4dannjjm 3485 12 be be VB cord-023095-4dannjjm 3485 13 prioritized prioritize VBN cord-023095-4dannjjm 3485 14 . . . cord-023095-4dannjjm 3486 1 Likewise likewise RB cord-023095-4dannjjm 3486 2 , , , cord-023095-4dannjjm 3486 3 the the DT cord-023095-4dannjjm 3486 4 detection detection NN cord-023095-4dannjjm 3486 5 of of IN cord-023095-4dannjjm 3486 6 Bartonella Bartonella NNP cord-023095-4dannjjm 3486 7 should should MD cord-023095-4dannjjm 3486 8 prompt prompt VB cord-023095-4dannjjm 3486 9 further further JJ cord-023095-4dannjjm 3486 10 testing testing NN cord-023095-4dannjjm 3486 11 for for IN cord-023095-4dannjjm 3486 12 endocarditis endocarditis NN cord-023095-4dannjjm 3486 13 , , , cord-023095-4dannjjm 3486 14 if if IN cord-023095-4dannjjm 3486 15 not not RB cord-023095-4dannjjm 3486 16 already already RB cord-023095-4dannjjm 3486 17 investigated investigate VBN cord-023095-4dannjjm 3486 18 . . . cord-023095-4dannjjm 3486 19 _SP cord-023095-4dannjjm 3487 1 Surveillance surveillance NN cord-023095-4dannjjm 3487 2 studies study NNS cord-023095-4dannjjm 3487 3 in in IN cord-023095-4dannjjm 3487 4 other other JJ cord-023095-4dannjjm 3487 5 species specie NNS cord-023095-4dannjjm 3487 6 depend depend VBP cord-023095-4dannjjm 3487 7 on on IN cord-023095-4dannjjm 3487 8 detection detection NN cord-023095-4dannjjm 3487 9 of of IN cord-023095-4dannjjm 3487 10 antibodies antibody NNS cord-023095-4dannjjm 3487 11 to to IN cord-023095-4dannjjm 3487 12 the the DT cord-023095-4dannjjm 3487 13 highly highly RB cord-023095-4dannjjm 3487 14 conserved conserve VBN cord-023095-4dannjjm 3487 15 influenza influenza NN cord-023095-4dannjjm 3487 16 A a DT cord-023095-4dannjjm 3487 17 nucleoprotein nucleoprotein JJ cord-023095-4dannjjm 3487 18 ( ( -LRB- cord-023095-4dannjjm 3487 19 NP NP NNP cord-023095-4dannjjm 3487 20 ) ) -RRB- cord-023095-4dannjjm 3487 21 ; ; : cord-023095-4dannjjm 3487 22 however however RB cord-023095-4dannjjm 3487 23 , , , cord-023095-4dannjjm 3487 24 no no DT cord-023095-4dannjjm 3487 25 such such JJ cord-023095-4dannjjm 3487 26 antibody antibody NN cord-023095-4dannjjm 3487 27 detection detection NN cord-023095-4dannjjm 3487 28 assay assay NN cord-023095-4dannjjm 3487 29 is be VBZ cord-023095-4dannjjm 3487 30 approved approve VBN cord-023095-4dannjjm 3487 31 for for IN cord-023095-4dannjjm 3487 32 canine canine JJ cord-023095-4dannjjm 3487 33 use use NN cord-023095-4dannjjm 3487 34 in in IN cord-023095-4dannjjm 3487 35 the the DT cord-023095-4dannjjm 3487 36 U.S. U.S. NNP cord-023095-4dannjjm 3488 1 The the DT cord-023095-4dannjjm 3488 2 purpose purpose NN cord-023095-4dannjjm 3488 3 of of IN cord-023095-4dannjjm 3488 4 this this DT cord-023095-4dannjjm 3488 5 study study NN cord-023095-4dannjjm 3488 6 was be VBD cord-023095-4dannjjm 3488 7 to to TO cord-023095-4dannjjm 3488 8 determine determine VB cord-023095-4dannjjm 3488 9 the the DT cord-023095-4dannjjm 3488 10 diagnostic diagnostic JJ cord-023095-4dannjjm 3488 11 accuracy accuracy NN cord-023095-4dannjjm 3488 12 of of IN cord-023095-4dannjjm 3488 13 a a DT cord-023095-4dannjjm 3488 14 commercial commercial JJ cord-023095-4dannjjm 3488 15 blocking block VBG cord-023095-4dannjjm 3488 16 ELISA ELISA NNP cord-023095-4dannjjm 3488 17 used use VBN cord-023095-4dannjjm 3488 18 for for IN cord-023095-4dannjjm 3488 19 avian avian JJ cord-023095-4dannjjm 3488 20 species specie NNS cord-023095-4dannjjm 3488 21 in in IN cord-023095-4dannjjm 3488 22 detecting detect VBG cord-023095-4dannjjm 3488 23 influenza influenza NN cord-023095-4dannjjm 3488 24 A a DT cord-023095-4dannjjm 3488 25 NP NP NNP cord-023095-4dannjjm 3488 26 antibody antibody NN cord-023095-4dannjjm 3488 27 in in IN cord-023095-4dannjjm 3488 28 dogs dog NNS cord-023095-4dannjjm 3488 29 . . . cord-023095-4dannjjm 3489 1 Since since IN cord-023095-4dannjjm 3489 2 the the DT cord-023095-4dannjjm 3489 3 blocking block VBG cord-023095-4dannjjm 3489 4 ELISA ELISA NNP cord-023095-4dannjjm 3489 5 is be VBZ cord-023095-4dannjjm 3489 6 not not RB cord-023095-4dannjjm 3489 7 a a DT cord-023095-4dannjjm 3489 8 species species NN cord-023095-4dannjjm 3489 9 - - HYPH cord-023095-4dannjjm 3489 10 specific specific JJ cord-023095-4dannjjm 3489 11 or or CC cord-023095-4dannjjm 3489 12 viral viral JJ cord-023095-4dannjjm 3489 13 subtype subtype NN cord-023095-4dannjjm 3489 14 - - HYPH cord-023095-4dannjjm 3489 15 specific specific JJ cord-023095-4dannjjm 3489 16 format format NN cord-023095-4dannjjm 3489 17 , , , cord-023095-4dannjjm 3489 18 we -PRON- PRP cord-023095-4dannjjm 3489 19 hypothesized hypothesize VBD cord-023095-4dannjjm 3489 20 that that IN cord-023095-4dannjjm 3489 21 it -PRON- PRP cord-023095-4dannjjm 3489 22 would would MD cord-023095-4dannjjm 3489 23 detect detect VB cord-023095-4dannjjm 3489 24 NP NP NNP cord-023095-4dannjjm 3489 25 antibodies antibody NNS cord-023095-4dannjjm 3489 26 in in IN cord-023095-4dannjjm 3489 27 dogs dog NNS cord-023095-4dannjjm 3489 28 infected infect VBN cord-023095-4dannjjm 3489 29 by by IN cord-023095-4dannjjm 3489 30 influenza influenza NN cord-023095-4dannjjm 3489 31 A a DT cord-023095-4dannjjm 3489 32 virus virus NN cord-023095-4dannjjm 3489 33 . . . cord-023095-4dannjjm 3490 1 Serum serum NN cord-023095-4dannjjm 3490 2 samples sample NNS cord-023095-4dannjjm 3490 3 from from IN cord-023095-4dannjjm 3490 4 uninfected uninfected JJ cord-023095-4dannjjm 3490 5 dogs dog NNS cord-023095-4dannjjm 3490 6 ( ( -LRB- cord-023095-4dannjjm 3490 7 n n NN cord-023095-4dannjjm 3490 8 5 5 CD cord-023095-4dannjjm 3490 9 204 204 CD cord-023095-4dannjjm 3490 10 ) ) -RRB- cord-023095-4dannjjm 3490 11 and and CC cord-023095-4dannjjm 3490 12 dogs dog NNS cord-023095-4dannjjm 3490 13 naturally naturally RB cord-023095-4dannjjm 3490 14 infected infect VBN cord-023095-4dannjjm 3490 15 with with IN cord-023095-4dannjjm 3490 16 canine canine JJ cord-023095-4dannjjm 3490 17 influenza influenza NN cord-023095-4dannjjm 3490 18 H3N8 H3N8 NNP cord-023095-4dannjjm 3490 19 ( ( -LRB- cord-023095-4dannjjm 3490 20 n n NN cord-023095-4dannjjm 3490 21 5 5 CD cord-023095-4dannjjm 3490 22 150 150 CD cord-023095-4dannjjm 3490 23 ) ) -RRB- cord-023095-4dannjjm 3490 24 were be VBD cord-023095-4dannjjm 3490 25 tested test VBN cord-023095-4dannjjm 3490 26 using use VBG cord-023095-4dannjjm 3490 27 the the DT cord-023095-4dannjjm 3490 28 IDEXX IDEXX NNP cord-023095-4dannjjm 3490 29 FlockChek FlockChek NNP cord-023095-4dannjjm 3490 30 blocking block VBG cord-023095-4dannjjm 3490 31 ELISA ELISA NNP cord-023095-4dannjjm 3490 32 for for IN cord-023095-4dannjjm 3490 33 influenza influenza NN cord-023095-4dannjjm 3490 34 A a DT cord-023095-4dannjjm 3490 35 NP NP NNP cord-023095-4dannjjm 3490 36 antibody antibody NN cord-023095-4dannjjm 3490 37 according accord VBG cord-023095-4dannjjm 3490 38 to to IN cord-023095-4dannjjm 3490 39 manufacturer manufacturer NN cord-023095-4dannjjm 3490 40 instructions instruction NNS cord-023095-4dannjjm 3490 41 . . . cord-023095-4dannjjm 3491 1 The the DT cord-023095-4dannjjm 3491 2 sample sample NN cord-023095-4dannjjm 3491 3 / / SYM cord-023095-4dannjjm 3491 4 negative negative JJ cord-023095-4dannjjm 3491 5 control control NN cord-023095-4dannjjm 3491 6 ( ( -LRB- cord-023095-4dannjjm 3491 7 S S NNP cord-023095-4dannjjm 3491 8 / / SYM cord-023095-4dannjjm 3491 9 N N NNP cord-023095-4dannjjm 3491 10 ) ) -RRB- cord-023095-4dannjjm 3491 11 absorbance absorbance NN cord-023095-4dannjjm 3491 12 ratios ratio NNS cord-023095-4dannjjm 3491 13 for for IN cord-023095-4dannjjm 3491 14 infected infected JJ cord-023095-4dannjjm 3491 15 dogs dog NNS cord-023095-4dannjjm 3491 16 ranged range VBD cord-023095-4dannjjm 3491 17 from from IN cord-023095-4dannjjm 3491 18 0.12 0.12 CD cord-023095-4dannjjm 3491 19 to to IN cord-023095-4dannjjm 3491 20 0.67 0.67 CD cord-023095-4dannjjm 3491 21 compared compare VBN cord-023095-4dannjjm 3491 22 to to IN cord-023095-4dannjjm 3491 23 0.53 0.53 CD cord-023095-4dannjjm 3491 24 to to IN cord-023095-4dannjjm 3491 25 1.40 1.40 CD cord-023095-4dannjjm 3491 26 for for IN cord-023095-4dannjjm 3491 27 uninfected uninfected JJ cord-023095-4dannjjm 3491 28 dogs dog NNS cord-023095-4dannjjm 3491 29 . . . cord-023095-4dannjjm 3492 1 A a DT cord-023095-4dannjjm 3492 2 receiver receiver NN cord-023095-4dannjjm 3492 3 operating operating NN cord-023095-4dannjjm 3492 4 characteristic characteristic NN cord-023095-4dannjjm 3492 5 ( ( -LRB- cord-023095-4dannjjm 3492 6 ROC ROC NNP cord-023095-4dannjjm 3492 7 ) ) -RRB- cord-023095-4dannjjm 3492 8 curve curve NN cord-023095-4dannjjm 3492 9 analysis analysis NN cord-023095-4dannjjm 3492 10 determined determine VBD cord-023095-4dannjjm 3492 11 optimum optimum JJ cord-023095-4dannjjm 3492 12 diagnostic diagnostic JJ cord-023095-4dannjjm 3492 13 sensitivity sensitivity NN cord-023095-4dannjjm 3492 14 ( ( -LRB- cord-023095-4dannjjm 3492 15 99.3 99.3 CD cord-023095-4dannjjm 3492 16 % % NN cord-023095-4dannjjm 3492 17 ) ) -RRB- cord-023095-4dannjjm 3492 18 and and CC cord-023095-4dannjjm 3492 19 specificity specificity NN cord-023095-4dannjjm 3492 20 ( ( -LRB- cord-023095-4dannjjm 3492 21 99.0 99.0 CD cord-023095-4dannjjm 3492 22 % % NN cord-023095-4dannjjm 3492 23 ) ) -RRB- cord-023095-4dannjjm 3492 24 at at IN cord-023095-4dannjjm 3492 25 a a DT cord-023095-4dannjjm 3492 26 S S NNP cord-023095-4dannjjm 3492 27 / / SYM cord-023095-4dannjjm 3492 28 N n CD cord-023095-4dannjjm 3492 29 cutoff cutoff NN cord-023095-4dannjjm 3492 30 ratio ratio NN cord-023095-4dannjjm 3492 31 of of IN cord-023095-4dannjjm 3492 32 0.647 0.647 CD cord-023095-4dannjjm 3492 33 . . . cord-023095-4dannjjm 3493 1 Using use VBG cord-023095-4dannjjm 3493 2 this this DT cord-023095-4dannjjm 3493 3 cutoff cutoff NN cord-023095-4dannjjm 3493 4 ratio ratio NN cord-023095-4dannjjm 3493 5 , , , cord-023095-4dannjjm 3493 6 the the DT cord-023095-4dannjjm 3493 7 overall overall JJ cord-023095-4dannjjm 3493 8 diagnostic diagnostic JJ cord-023095-4dannjjm 3493 9 accuracy accuracy NN cord-023095-4dannjjm 3493 10 was be VBD cord-023095-4dannjjm 3493 11 99.2 99.2 CD cord-023095-4dannjjm 3493 12 % % NN cord-023095-4dannjjm 3493 13 . . . cord-023095-4dannjjm 3494 1 Coefficients coefficient NNS cord-023095-4dannjjm 3494 2 of of IN cord-023095-4dannjjm 3494 3 variation variation NN cord-023095-4dannjjm 3494 4 for for IN cord-023095-4dannjjm 3494 5 intra intra JJ cord-023095-4dannjjm 3494 6 - - JJ cord-023095-4dannjjm 3494 7 assay assay JJ cord-023095-4dannjjm 3494 8 ( ( -LRB- cord-023095-4dannjjm 3494 9 4.7 4.7 CD cord-023095-4dannjjm 3494 10 % % NN cord-023095-4dannjjm 3494 11 ) ) -RRB- cord-023095-4dannjjm 3494 12 and and CC cord-023095-4dannjjm 3494 13 inter inter JJ cord-023095-4dannjjm 3494 14 - - NN cord-023095-4dannjjm 3494 15 assay assay NN cord-023095-4dannjjm 3494 16 ( ( -LRB- cord-023095-4dannjjm 3494 17 6.1 6.1 CD cord-023095-4dannjjm 3494 18 % % NN cord-023095-4dannjjm 3494 19 ) ) -RRB- cord-023095-4dannjjm 3494 20 testing testing NN cord-023095-4dannjjm 3494 21 demonstrated demonstrate VBD cord-023095-4dannjjm 3494 22 good good JJ cord-023095-4dannjjm 3494 23 repeatability repeatability NN cord-023095-4dannjjm 3494 24 with with IN cord-023095-4dannjjm 3494 25 canine canine JJ cord-023095-4dannjjm 3494 26 sera sera NNP cord-023095-4dannjjm 3494 27 . . . cord-023095-4dannjjm 3495 1 The the DT cord-023095-4dannjjm 3495 2 excellent excellent JJ cord-023095-4dannjjm 3495 3 diagnostic diagnostic JJ cord-023095-4dannjjm 3495 4 accuracy accuracy NN cord-023095-4dannjjm 3495 5 of of IN cord-023095-4dannjjm 3495 6 the the DT cord-023095-4dannjjm 3495 7 commercial commercial JJ cord-023095-4dannjjm 3495 8 blocking block VBG cord-023095-4dannjjm 3495 9 ELISA ELISA NNP cord-023095-4dannjjm 3495 10 makes make VBZ cord-023095-4dannjjm 3495 11 it -PRON- PRP cord-023095-4dannjjm 3495 12 a a DT cord-023095-4dannjjm 3495 13 suitable suitable JJ cord-023095-4dannjjm 3495 14 tool tool NN cord-023095-4dannjjm 3495 15 for for IN cord-023095-4dannjjm 3495 16 large large JJ cord-023095-4dannjjm 3495 17 - - HYPH cord-023095-4dannjjm 3495 18 scale scale NN cord-023095-4dannjjm 3495 19 surveillance surveillance NN cord-023095-4dannjjm 3495 20 of of IN cord-023095-4dannjjm 3495 21 influenza influenza NN cord-023095-4dannjjm 3495 22 A a DT cord-023095-4dannjjm 3495 23 virus virus NN cord-023095-4dannjjm 3495 24 exposure exposure NN cord-023095-4dannjjm 3495 25 in in IN cord-023095-4dannjjm 3495 26 dogs dog NNS cord-023095-4dannjjm 3495 27 . . . cord-023095-4dannjjm 3496 1 Upper upper JJ cord-023095-4dannjjm 3496 2 respiratory respiratory JJ cord-023095-4dannjjm 3496 3 disease disease NN cord-023095-4dannjjm 3496 4 ( ( -LRB- cord-023095-4dannjjm 3496 5 URD URD NNP cord-023095-4dannjjm 3496 6 ) ) -RRB- cord-023095-4dannjjm 3496 7 can can MD cord-023095-4dannjjm 3496 8 affect affect VB cord-023095-4dannjjm 3496 9 a a DT cord-023095-4dannjjm 3496 10 majority majority NN cord-023095-4dannjjm 3496 11 of of IN cord-023095-4dannjjm 3496 12 cats cat NNS cord-023095-4dannjjm 3496 13 in in IN cord-023095-4dannjjm 3496 14 shelters shelter NNS cord-023095-4dannjjm 3496 15 and and CC cord-023095-4dannjjm 3496 16 is be VBZ cord-023095-4dannjjm 3496 17 one one CD cord-023095-4dannjjm 3496 18 of of IN cord-023095-4dannjjm 3496 19 the the DT cord-023095-4dannjjm 3496 20 leading lead VBG cord-023095-4dannjjm 3496 21 reasons reason NNS cord-023095-4dannjjm 3496 22 for for IN cord-023095-4dannjjm 3496 23 euthanasia euthanasia NN cord-023095-4dannjjm 3496 24 of of IN cord-023095-4dannjjm 3496 25 otherwise otherwise RB cord-023095-4dannjjm 3496 26 adoptable adoptable JJ cord-023095-4dannjjm 3496 27 cats cat NNS cord-023095-4dannjjm 3496 28 . . . cord-023095-4dannjjm 3497 1 The the DT cord-023095-4dannjjm 3497 2 purpose purpose NN cord-023095-4dannjjm 3497 3 of of IN cord-023095-4dannjjm 3497 4 this this DT cord-023095-4dannjjm 3497 5 study study NN cord-023095-4dannjjm 3497 6 was be VBD cord-023095-4dannjjm 3497 7 to to TO cord-023095-4dannjjm 3497 8 determine determine VB cord-023095-4dannjjm 3497 9 prevalence prevalence NN cord-023095-4dannjjm 3497 10 and and CC cord-023095-4dannjjm 3497 11 risk risk NN cord-023095-4dannjjm 3497 12 factors factor NNS cord-023095-4dannjjm 3497 13 for for IN cord-023095-4dannjjm 3497 14 upper upper JJ cord-023095-4dannjjm 3497 15 respiratory respiratory JJ cord-023095-4dannjjm 3497 16 pathogens pathogen NNS cord-023095-4dannjjm 3497 17 in in IN cord-023095-4dannjjm 3497 18 four four CD cord-023095-4dannjjm 3497 19 different different JJ cord-023095-4dannjjm 3497 20 models model NNS cord-023095-4dannjjm 3497 21 for for IN cord-023095-4dannjjm 3497 22 managing manage VBG cord-023095-4dannjjm 3497 23 unowned unowned JJ cord-023095-4dannjjm 3497 24 cats cat NNS cord-023095-4dannjjm 3497 25 : : : cord-023095-4dannjjm 3497 26 short short JJ cord-023095-4dannjjm 3497 27 - - HYPH cord-023095-4dannjjm 3497 28 term term NN cord-023095-4dannjjm 3497 29 animal animal NN cord-023095-4dannjjm 3497 30 shelters shelter NNS cord-023095-4dannjjm 3497 31 ( ( -LRB- cord-023095-4dannjjm 3497 32 SHEL SHEL NNP cord-023095-4dannjjm 3497 33 ) ) -RRB- cord-023095-4dannjjm 3497 34 , , , cord-023095-4dannjjm 3497 35 long long JJ cord-023095-4dannjjm 3497 36 - - HYPH cord-023095-4dannjjm 3497 37 term term NN cord-023095-4dannjjm 3497 38 sanctuaries sanctuary NNS cord-023095-4dannjjm 3497 39 ( ( -LRB- cord-023095-4dannjjm 3497 40 SANC SANC NNP cord-023095-4dannjjm 3497 41 ) ) -RRB- cord-023095-4dannjjm 3497 42 , , , cord-023095-4dannjjm 3497 43 home home NN cord-023095-4dannjjm 3497 44 - - HYPH cord-023095-4dannjjm 3497 45 based base VBN cord-023095-4dannjjm 3497 46 foster foster JJ cord-023095-4dannjjm 3497 47 care care NN cord-023095-4dannjjm 3497 48 ( ( -LRB- cord-023095-4dannjjm 3497 49 FOST FOST NNP cord-023095-4dannjjm 3497 50 ) ) -RRB- cord-023095-4dannjjm 3497 51 , , , cord-023095-4dannjjm 3497 52 and and CC cord-023095-4dannjjm 3497 53 trap trap NN cord-023095-4dannjjm 3497 54 - - HYPH cord-023095-4dannjjm 3497 55 neuter neuter NN cord-023095-4dannjjm 3497 56 - - JJ cord-023095-4dannjjm 3497 57 return return NN cord-023095-4dannjjm 3497 58 ( ( -LRB- cord-023095-4dannjjm 3497 59 TNR TNR NNP cord-023095-4dannjjm 3497 60 ) ) -RRB- cord-023095-4dannjjm 3497 61 programs program NNS cord-023095-4dannjjm 3497 62 . . . cord-023095-4dannjjm 3498 1 Conjunctival conjunctival NN cord-023095-4dannjjm 3498 2 and and CC cord-023095-4dannjjm 3498 3 oropharyngeal oropharyngeal JJ cord-023095-4dannjjm 3498 4 swabs swab NNS cord-023095-4dannjjm 3498 5 were be VBD cord-023095-4dannjjm 3498 6 collected collect VBN cord-023095-4dannjjm 3498 7 from from IN cord-023095-4dannjjm 3498 8 543 543 CD cord-023095-4dannjjm 3498 9 cats cat NNS cord-023095-4dannjjm 3498 10 , , , cord-023095-4dannjjm 3498 11 half half NN cord-023095-4dannjjm 3498 12 of of IN cord-023095-4dannjjm 3498 13 which which WDT cord-023095-4dannjjm 3498 14 had have VBD cord-023095-4dannjjm 3498 15 clinical clinical JJ cord-023095-4dannjjm 3498 16 signs sign NNS cord-023095-4dannjjm 3498 17 of of IN cord-023095-4dannjjm 3498 18 URD URD NNP cord-023095-4dannjjm 3498 19 , , , cord-023095-4dannjjm 3498 20 and and CC cord-023095-4dannjjm 3498 21 tested test VBN cord-023095-4dannjjm 3498 22 for for IN cord-023095-4dannjjm 3498 23 feline feline JJ cord-023095-4dannjjm 3498 24 herpesvirus herpesvirus NN cord-023095-4dannjjm 3498 25 ( ( -LRB- cord-023095-4dannjjm 3498 26 FHV FHV NNP cord-023095-4dannjjm 3498 27 ) ) -RRB- cord-023095-4dannjjm 3498 28 , , , cord-023095-4dannjjm 3498 29 feline feline JJ cord-023095-4dannjjm 3498 30 calicivirus calicivirus NNP cord-023095-4dannjjm 3498 31 ( ( -LRB- cord-023095-4dannjjm 3498 32 FCV FCV NNP cord-023095-4dannjjm 3498 33 ) ) -RRB- cord-023095-4dannjjm 3498 34 , , , cord-023095-4dannjjm 3498 35 Chlamydiophila Chlamydiophila NNP cord-023095-4dannjjm 3498 36 felis felis NN cord-023095-4dannjjm 3498 37 , , , cord-023095-4dannjjm 3498 38 Bordetella Bordetella NNP cord-023095-4dannjjm 3498 39 bronchiseptica bronchiseptica NNP cord-023095-4dannjjm 3498 40 ( ( -LRB- cord-023095-4dannjjm 3498 41 Bb Bb NNP cord-023095-4dannjjm 3498 42 ) ) -RRB- cord-023095-4dannjjm 3498 43 and and CC cord-023095-4dannjjm 3498 44 Mycoplasma Mycoplasma NNP cord-023095-4dannjjm 3498 45 felis felis NN cord-023095-4dannjjm 3498 46 by by IN cord-023095-4dannjjm 3498 47 real real JJ cord-023095-4dannjjm 3498 48 - - HYPH cord-023095-4dannjjm 3498 49 time time NN cord-023095-4dannjjm 3498 50 PCR PCR NNP cord-023095-4dannjjm 3498 51 . . . cord-023095-4dannjjm 3499 1 Management management NN cord-023095-4dannjjm 3499 2 model model NN cord-023095-4dannjjm 3499 3 , , , cord-023095-4dannjjm 3499 4 vaccination vaccination NN cord-023095-4dannjjm 3499 5 , , , cord-023095-4dannjjm 3499 6 sex sex NN cord-023095-4dannjjm 3499 7 , , , cord-023095-4dannjjm 3499 8 age age NN cord-023095-4dannjjm 3499 9 , , , cord-023095-4dannjjm 3499 10 body body NN cord-023095-4dannjjm 3499 11 condition condition NN cord-023095-4dannjjm 3499 12 , , , cord-023095-4dannjjm 3499 13 and and CC cord-023095-4dannjjm 3499 14 clinical clinical JJ cord-023095-4dannjjm 3499 15 signs sign NNS cord-023095-4dannjjm 3499 16 were be VBD cord-023095-4dannjjm 3499 17 evaluated evaluate VBN cord-023095-4dannjjm 3499 18 as as IN cord-023095-4dannjjm 3499 19 risk risk NN cord-023095-4dannjjm 3499 20 factors factor NNS cord-023095-4dannjjm 3499 21 for for IN cord-023095-4dannjjm 3499 22 infection infection NN cord-023095-4dannjjm 3499 23 . . . cord-023095-4dannjjm 3500 1 A a DT cord-023095-4dannjjm 3500 2 majority majority NN cord-023095-4dannjjm 3500 3 of of IN cord-023095-4dannjjm 3500 4 cats cat NNS cord-023095-4dannjjm 3500 5 in in IN cord-023095-4dannjjm 3500 6 all all DT cord-023095-4dannjjm 3500 7 management management NN cord-023095-4dannjjm 3500 8 models model NNS cord-023095-4dannjjm 3500 9 carried carry VBD cord-023095-4dannjjm 3500 10 one one CD cord-023095-4dannjjm 3500 11 or or CC cord-023095-4dannjjm 3500 12 more more JJR cord-023095-4dannjjm 3500 13 organisms organism NNS cord-023095-4dannjjm 3500 14 capable capable JJ cord-023095-4dannjjm 3500 15 of of IN cord-023095-4dannjjm 3500 16 causing cause VBG cord-023095-4dannjjm 3500 17 URD URD NNP cord-023095-4dannjjm 3500 18 . . . cord-023095-4dannjjm 3501 1 In in IN cord-023095-4dannjjm 3501 2 many many JJ cord-023095-4dannjjm 3501 3 cases case NNS cord-023095-4dannjjm 3501 4 , , , cord-023095-4dannjjm 3501 5 prevalence prevalence NN cord-023095-4dannjjm 3501 6 was be VBD cord-023095-4dannjjm 3501 7 similar similar JJ cord-023095-4dannjjm 3501 8 in in IN cord-023095-4dannjjm 3501 9 cats cat NNS cord-023095-4dannjjm 3501 10 with with IN cord-023095-4dannjjm 3501 11 or or CC cord-023095-4dannjjm 3501 12 without without IN cord-023095-4dannjjm 3501 13 clinical clinical JJ cord-023095-4dannjjm 3501 14 signs sign NNS cord-023095-4dannjjm 3501 15 . . . cord-023095-4dannjjm 3502 1 Unlike unlike IN cord-023095-4dannjjm 3502 2 diseases disease NNS cord-023095-4dannjjm 3502 3 that that WDT cord-023095-4dannjjm 3502 4 can can MD cord-023095-4dannjjm 3502 5 be be VB cord-023095-4dannjjm 3502 6 controlled control VBN cord-023095-4dannjjm 3502 7 by by IN cord-023095-4dannjjm 3502 8 segregation segregation NN cord-023095-4dannjjm 3502 9 of of IN cord-023095-4dannjjm 3502 10 symptomatic symptomatic JJ cord-023095-4dannjjm 3502 11 animals animal NNS cord-023095-4dannjjm 3502 12 , , , cord-023095-4dannjjm 3502 13 the the DT cord-023095-4dannjjm 3502 14 lack lack NN cord-023095-4dannjjm 3502 15 of of IN cord-023095-4dannjjm 3502 16 strong strong JJ cord-023095-4dannjjm 3502 17 correlation correlation NN cord-023095-4dannjjm 3502 18 between between IN cord-023095-4dannjjm 3502 19 the the DT cord-023095-4dannjjm 3502 20 presence presence NN cord-023095-4dannjjm 3502 21 of of IN cord-023095-4dannjjm 3502 22 pathogens pathogen NNS cord-023095-4dannjjm 3502 23 with with IN cord-023095-4dannjjm 3502 24 the the DT cord-023095-4dannjjm 3502 25 presence presence NN cord-023095-4dannjjm 3502 26 of of IN cord-023095-4dannjjm 3502 27 clinical clinical JJ cord-023095-4dannjjm 3502 28 signs sign NNS cord-023095-4dannjjm 3502 29 suggests suggest VBZ cord-023095-4dannjjm 3502 30 that that IN cord-023095-4dannjjm 3502 31 feline feline JJ cord-023095-4dannjjm 3502 32 URD URD NNP cord-023095-4dannjjm 3502 33 control control NN cord-023095-4dannjjm 3502 34 should should MD cord-023095-4dannjjm 3502 35 be be VB cord-023095-4dannjjm 3502 36 managed manage VBN cord-023095-4dannjjm 3502 37 by by IN cord-023095-4dannjjm 3502 38 vaccination vaccination NN cord-023095-4dannjjm 3502 39 before before IN cord-023095-4dannjjm 3502 40 or or CC cord-023095-4dannjjm 3502 41 at at IN cord-023095-4dannjjm 3502 42 the the DT cord-023095-4dannjjm 3502 43 time time NN cord-023095-4dannjjm 3502 44 of of IN cord-023095-4dannjjm 3502 45 intake intake NN cord-023095-4dannjjm 3502 46 , , , cord-023095-4dannjjm 3502 47 biosecurity biosecurity NN cord-023095-4dannjjm 3502 48 protocols protocol NNS cord-023095-4dannjjm 3502 49 that that WDT cord-023095-4dannjjm 3502 50 presume presume VBP cord-023095-4dannjjm 3502 51 all all DT cord-023095-4dannjjm 3502 52 cats cat NNS cord-023095-4dannjjm 3502 53 may may MD cord-023095-4dannjjm 3502 54 be be VB cord-023095-4dannjjm 3502 55 shedding shed VBG cord-023095-4dannjjm 3502 56 pathogens pathogen NNS cord-023095-4dannjjm 3502 57 , , , cord-023095-4dannjjm 3502 58 and and CC cord-023095-4dannjjm 3502 59 minimizing minimize VBG cord-023095-4dannjjm 3502 60 stressful stressful JJ cord-023095-4dannjjm 3502 61 conditions condition NNS cord-023095-4dannjjm 3502 62 that that WDT cord-023095-4dannjjm 3502 63 contribute contribute VBP cord-023095-4dannjjm 3502 64 to to IN cord-023095-4dannjjm 3502 65 disease disease NN cord-023095-4dannjjm 3502 66 susceptibility susceptibility NN cord-023095-4dannjjm 3502 67 . . . cord-023095-4dannjjm 3503 1 Depending depend VBG cord-023095-4dannjjm 3503 2 on on IN cord-023095-4dannjjm 3503 3 geographical geographical JJ cord-023095-4dannjjm 3503 4 location location NN cord-023095-4dannjjm 3503 5 , , , cord-023095-4dannjjm 3503 6 sex sex NN cord-023095-4dannjjm 3503 7 , , , cord-023095-4dannjjm 3503 8 age age NN cord-023095-4dannjjm 3503 9 and and CC cord-023095-4dannjjm 3503 10 environment environment NN cord-023095-4dannjjm 3503 11 , , , cord-023095-4dannjjm 3503 12 2 2 CD cord-023095-4dannjjm 3503 13 - - SYM cord-023095-4dannjjm 3503 14 40 40 CD cord-023095-4dannjjm 3503 15 % % NN cord-023095-4dannjjm 3503 16 of of IN cord-023095-4dannjjm 3503 17 cats cat NNS cord-023095-4dannjjm 3503 18 worldwide worldwide RB cord-023095-4dannjjm 3503 19 are be VBP cord-023095-4dannjjm 3503 20 infected infect VBN cord-023095-4dannjjm 3503 21 with with IN cord-023095-4dannjjm 3503 22 the the DT cord-023095-4dannjjm 3503 23 feline feline JJ cord-023095-4dannjjm 3503 24 immunodeficiency immunodeficiency NN cord-023095-4dannjjm 3503 25 virus virus NN cord-023095-4dannjjm 3503 26 ( ( -LRB- cord-023095-4dannjjm 3503 27 FIV FIV NNP cord-023095-4dannjjm 3503 28 ) ) -RRB- cord-023095-4dannjjm 3503 29 . . . cord-023095-4dannjjm 3504 1 Knowledge knowledge NN cord-023095-4dannjjm 3504 2 of of IN cord-023095-4dannjjm 3504 3 the the DT cord-023095-4dannjjm 3504 4 FIV FIV NNP cord-023095-4dannjjm 3504 5 status status NN cord-023095-4dannjjm 3504 6 of of IN cord-023095-4dannjjm 3504 7 cats cat NNS cord-023095-4dannjjm 3504 8 is be VBZ cord-023095-4dannjjm 3504 9 important important JJ cord-023095-4dannjjm 3504 10 to to TO cord-023095-4dannjjm 3504 11 limit limit VB cord-023095-4dannjjm 3504 12 the the DT cord-023095-4dannjjm 3504 13 spread spread NN cord-023095-4dannjjm 3504 14 of of IN cord-023095-4dannjjm 3504 15 disease disease NN cord-023095-4dannjjm 3504 16 and and CC cord-023095-4dannjjm 3504 17 to to TO cord-023095-4dannjjm 3504 18 institute institute VB cord-023095-4dannjjm 3504 19 appropriate appropriate JJ cord-023095-4dannjjm 3504 20 health health NN cord-023095-4dannjjm 3504 21 management management NN cord-023095-4dannjjm 3504 22 . . . cord-023095-4dannjjm 3505 1 However however RB cord-023095-4dannjjm 3505 2 , , , cord-023095-4dannjjm 3505 3 like like IN cord-023095-4dannjjm 3505 4 all all DT cord-023095-4dannjjm 3505 5 lentiviruses lentiviruse NNS cord-023095-4dannjjm 3505 6 , , , cord-023095-4dannjjm 3505 7 FIV FIV NNP cord-023095-4dannjjm 3505 8 is be VBZ cord-023095-4dannjjm 3505 9 highly highly RB cord-023095-4dannjjm 3505 10 variable variable JJ cord-023095-4dannjjm 3505 11 in in IN cord-023095-4dannjjm 3505 12 nucleotide nucleotide JJ cord-023095-4dannjjm 3505 13 sequence sequence NN cord-023095-4dannjjm 3505 14 , , , cord-023095-4dannjjm 3505 15 and and CC cord-023095-4dannjjm 3505 16 viral viral JJ cord-023095-4dannjjm 3505 17 load load NN cord-023095-4dannjjm 3505 18 in in IN cord-023095-4dannjjm 3505 19 cats cat NNS cord-023095-4dannjjm 3505 20 is be VBZ cord-023095-4dannjjm 3505 21 variable variable JJ cord-023095-4dannjjm 3505 22 during during IN cord-023095-4dannjjm 3505 23 different different JJ cord-023095-4dannjjm 3505 24 disease disease NN cord-023095-4dannjjm 3505 25 stages stage NNS cord-023095-4dannjjm 3505 26 . . . cord-023095-4dannjjm 3506 1 Detection detection NN cord-023095-4dannjjm 3506 2 of of IN cord-023095-4dannjjm 3506 3 antibodies antibody NNS cord-023095-4dannjjm 3506 4 is be VBZ cord-023095-4dannjjm 3506 5 the the DT cord-023095-4dannjjm 3506 6 most most RBS cord-023095-4dannjjm 3506 7 widely widely RB cord-023095-4dannjjm 3506 8 employed employ VBN cord-023095-4dannjjm 3506 9 diagnostic diagnostic JJ cord-023095-4dannjjm 3506 10 approach approach NN cord-023095-4dannjjm 3506 11 , , , cord-023095-4dannjjm 3506 12 but but CC cord-023095-4dannjjm 3506 13 does do VBZ cord-023095-4dannjjm 3506 14 not not RB cord-023095-4dannjjm 3506 15 distinguish distinguish VB cord-023095-4dannjjm 3506 16 FIV FIV NNP cord-023095-4dannjjm 3506 17 - - HYPH cord-023095-4dannjjm 3506 18 infected infect VBN cord-023095-4dannjjm 3506 19 from from IN cord-023095-4dannjjm 3506 20 FIV fiv NN cord-023095-4dannjjm 3506 21 - - HYPH cord-023095-4dannjjm 3506 22 vaccinated vaccinate VBN cord-023095-4dannjjm 3506 23 cats cat NNS cord-023095-4dannjjm 3506 24 . . . cord-023095-4dannjjm 3507 1 In in IN cord-023095-4dannjjm 3507 2 this this DT cord-023095-4dannjjm 3507 3 study study NN cord-023095-4dannjjm 3507 4 , , , cord-023095-4dannjjm 3507 5 samples sample NNS cord-023095-4dannjjm 3507 6 from from IN cord-023095-4dannjjm 3507 7 30 30 CD cord-023095-4dannjjm 3507 8 FIV fiv NN cord-023095-4dannjjm 3507 9 - - HYPH cord-023095-4dannjjm 3507 10 seronegative seronegative JJ cord-023095-4dannjjm 3507 11 cats cat NNS cord-023095-4dannjjm 3507 12 , , , cord-023095-4dannjjm 3507 13 30 30 CD cord-023095-4dannjjm 3507 14 FIVseropositive fivseropositive NN cord-023095-4dannjjm 3507 15 cats cat NNS cord-023095-4dannjjm 3507 16 , , , cord-023095-4dannjjm 3507 17 and and CC cord-023095-4dannjjm 3507 18 30 30 CD cord-023095-4dannjjm 3507 19 FIV fiv NN cord-023095-4dannjjm 3507 20 - - HYPH cord-023095-4dannjjm 3507 21 historically historically RB cord-023095-4dannjjm 3507 22 seronegative seronegative JJ cord-023095-4dannjjm 3507 23 but but CC cord-023095-4dannjjm 3507 24 vaccinated vaccinated JJ cord-023095-4dannjjm 3507 25 cats cat NNS cord-023095-4dannjjm 3507 26 , , , cord-023095-4dannjjm 3507 27 were be VBD cord-023095-4dannjjm 3507 28 analyzed analyze VBN cord-023095-4dannjjm 3507 29 by by IN cord-023095-4dannjjm 3507 30 a a DT cord-023095-4dannjjm 3507 31 commercial commercial JJ cord-023095-4dannjjm 3507 32 quantitative quantitative JJ cord-023095-4dannjjm 3507 33 PCR PCR NNP cord-023095-4dannjjm 3507 34 ( ( -LRB- cord-023095-4dannjjm 3507 35 qPCR qPCR NNP cord-023095-4dannjjm 3507 36 ) ) -RRB- cord-023095-4dannjjm 3507 37 assay assay NN cord-023095-4dannjjm 3507 38 and and CC cord-023095-4dannjjm 3507 39 virus virus NN cord-023095-4dannjjm 3507 40 isolation isolation NN cord-023095-4dannjjm 3507 41 . . . cord-023095-4dannjjm 3508 1 Replicate replicate VB cord-023095-4dannjjm 3508 2 blood blood NN cord-023095-4dannjjm 3508 3 samples sample NNS cord-023095-4dannjjm 3508 4 were be VBD cord-023095-4dannjjm 3508 5 coded code VBN cord-023095-4dannjjm 3508 6 , , , cord-023095-4dannjjm 3508 7 and and CC cord-023095-4dannjjm 3508 8 then then RB cord-023095-4dannjjm 3508 9 submitted submit VBD cord-023095-4dannjjm 3508 10 for for IN cord-023095-4dannjjm 3508 11 1 1 CD cord-023095-4dannjjm 3508 12 ) ) -RRB- cord-023095-4dannjjm 3509 1 qPCR qPCR NNP cord-023095-4dannjjm 3509 2 ( ( -LRB- cord-023095-4dannjjm 3509 3 Idexx Idexx NNP cord-023095-4dannjjm 3509 4 ) ) -RRB- cord-023095-4dannjjm 3509 5 ; ; : cord-023095-4dannjjm 3509 6 and and CC cord-023095-4dannjjm 3509 7 2 2 LS cord-023095-4dannjjm 3509 8 ) ) -RRB- cord-023095-4dannjjm 3509 9 mononuclear mononuclear JJ cord-023095-4dannjjm 3509 10 cell cell NN cord-023095-4dannjjm 3509 11 isolation isolation NN cord-023095-4dannjjm 3509 12 with with IN cord-023095-4dannjjm 3509 13 7-day 7-day JJ cord-023095-4dannjjm 3509 14 culture culture NN cord-023095-4dannjjm 3509 15 and and CC cord-023095-4dannjjm 3509 16 viral viral JJ cord-023095-4dannjjm 3509 17 p24 p24 NN cord-023095-4dannjjm 3509 18 antigen antigen NN cord-023095-4dannjjm 3509 19 detection detection NN cord-023095-4dannjjm 3509 20 by by IN cord-023095-4dannjjm 3509 21 ELISA ELISA NNP cord-023095-4dannjjm 3509 22 . . . cord-023095-4dannjjm 3510 1 For for IN cord-023095-4dannjjm 3510 2 the the DT cord-023095-4dannjjm 3510 3 p24 p24 NN cord-023095-4dannjjm 3510 4 antigen antigen NN cord-023095-4dannjjm 3510 5 ELISA ELISA NNP cord-023095-4dannjjm 3510 6 , , , cord-023095-4dannjjm 3510 7 cutoff cutoff NN cord-023095-4dannjjm 3510 8 absorbance absorbance NN cord-023095-4dannjjm 3510 9 values value NNS cord-023095-4dannjjm 3510 10 were be VBD cord-023095-4dannjjm 3510 11 established establish VBN cord-023095-4dannjjm 3510 12 from from IN cord-023095-4dannjjm 3510 13 analysis analysis NN cord-023095-4dannjjm 3510 14 of of IN cord-023095-4dannjjm 3510 15 10 10 CD cord-023095-4dannjjm 3510 16 FIV fiv JJ cord-023095-4dannjjm 3510 17 - - HYPH cord-023095-4dannjjm 3510 18 negative negative JJ cord-023095-4dannjjm 3510 19 samples sample NNS cord-023095-4dannjjm 3510 20 . . . cord-023095-4dannjjm 3511 1 FIV fiv NN cord-023095-4dannjjm 3511 2 infection infection NN cord-023095-4dannjjm 3511 3 status status NN cord-023095-4dannjjm 3511 4 was be VBD cord-023095-4dannjjm 3511 5 pre pre JJ cord-023095-4dannjjm 3511 6 - - JJ cord-023095-4dannjjm 3511 7 determined determined JJ cord-023095-4dannjjm 3511 8 based base VBN cord-023095-4dannjjm 3511 9 on on IN cord-023095-4dannjjm 3511 10 2 2 CD cord-023095-4dannjjm 3511 11 antibody antibody NN cord-023095-4dannjjm 3511 12 - - HYPH cord-023095-4dannjjm 3511 13 ELISA ELISA NNP cord-023095-4dannjjm 3511 14 results result NNS cord-023095-4dannjjm 3511 15 and and CC cord-023095-4dannjjm 3511 16 vaccination vaccination NN cord-023095-4dannjjm 3511 17 history history NN cord-023095-4dannjjm 3511 18 . . . cord-023095-4dannjjm 3512 1 Results result NNS cord-023095-4dannjjm 3512 2 indicated indicate VBD cord-023095-4dannjjm 3512 3 that that IN cord-023095-4dannjjm 3512 4 qPCR qPCR NNP cord-023095-4dannjjm 3512 5 had have VBD cord-023095-4dannjjm 3512 6 a a DT cord-023095-4dannjjm 3512 7 sensitivity sensitivity NN cord-023095-4dannjjm 3512 8 of of IN cord-023095-4dannjjm 3512 9 76 76 CD cord-023095-4dannjjm 3512 10 % % NN cord-023095-4dannjjm 3512 11 for for IN cord-023095-4dannjjm 3512 12 samples sample NNS cord-023095-4dannjjm 3512 13 from from IN cord-023095-4dannjjm 3512 14 FIV fiv NN cord-023095-4dannjjm 3512 15 - - HYPH cord-023095-4dannjjm 3512 16 seropositive seropositive JJ cord-023095-4dannjjm 3512 17 cats cat NNS cord-023095-4dannjjm 3512 18 , , , cord-023095-4dannjjm 3512 19 and and CC cord-023095-4dannjjm 3512 20 a a DT cord-023095-4dannjjm 3512 21 specificity specificity NN cord-023095-4dannjjm 3512 22 of of IN cord-023095-4dannjjm 3512 23 100 100 CD cord-023095-4dannjjm 3512 24 % % NN cord-023095-4dannjjm 3512 25 and and CC cord-023095-4dannjjm 3512 26 94.1 94.1 CD cord-023095-4dannjjm 3512 27 % % NN cord-023095-4dannjjm 3512 28 for for IN cord-023095-4dannjjm 3512 29 samples sample NNS cord-023095-4dannjjm 3512 30 from from IN cord-023095-4dannjjm 3512 31 FIV fiv NN cord-023095-4dannjjm 3512 32 - - HYPH cord-023095-4dannjjm 3512 33 seronegative seronegative JJ cord-023095-4dannjjm 3512 34 and and CC cord-023095-4dannjjm 3512 35 FIV fiv NN cord-023095-4dannjjm 3512 36 - - HYPH cord-023095-4dannjjm 3512 37 vaccinated vaccinate VBN cord-023095-4dannjjm 3512 38 cats cat NNS cord-023095-4dannjjm 3512 39 , , , cord-023095-4dannjjm 3512 40 respectively respectively RB cord-023095-4dannjjm 3512 41 . . . cord-023095-4dannjjm 3513 1 At at IN cord-023095-4dannjjm 3513 2 a a DT cord-023095-4dannjjm 3513 3 cutoff cutoff NN cord-023095-4dannjjm 3513 4 value value NN cord-023095-4dannjjm 3513 5 of of IN cord-023095-4dannjjm 3513 6 3 3 CD cord-023095-4dannjjm 3513 7 standard standard JJ cord-023095-4dannjjm 3513 8 deviations deviation NNS cord-023095-4dannjjm 3513 9 above above IN cord-023095-4dannjjm 3513 10 the the DT cord-023095-4dannjjm 3513 11 mean mean JJ cord-023095-4dannjjm 3513 12 absorbance absorbance NN cord-023095-4dannjjm 3513 13 for for IN cord-023095-4dannjjm 3513 14 p24 p24 NN cord-023095-4dannjjm 3513 15 antigen antigen NN cord-023095-4dannjjm 3513 16 ELISA ELISA NNP cord-023095-4dannjjm 3513 17 , , , cord-023095-4dannjjm 3513 18 results result VBZ cord-023095-4dannjjm 3513 19 from from IN cord-023095-4dannjjm 3513 20 FIV fiv JJ cord-023095-4dannjjm 3513 21 - - HYPH cord-023095-4dannjjm 3513 22 negative negative JJ cord-023095-4dannjjm 3513 23 samples sample NNS cord-023095-4dannjjm 3513 24 yielded yield VBD cord-023095-4dannjjm 3513 25 a a DT cord-023095-4dannjjm 3513 26 sensitivity sensitivity NN cord-023095-4dannjjm 3513 27 of of IN cord-023095-4dannjjm 3513 28 69.2 69.2 CD cord-023095-4dannjjm 3513 29 % % NN cord-023095-4dannjjm 3513 30 for for IN cord-023095-4dannjjm 3513 31 samples sample NNS cord-023095-4dannjjm 3513 32 from from IN cord-023095-4dannjjm 3513 33 FIV fiv NN cord-023095-4dannjjm 3513 34 - - HYPH cord-023095-4dannjjm 3513 35 seropositive seropositive JJ cord-023095-4dannjjm 3513 36 cats cat NNS cord-023095-4dannjjm 3513 37 , , , cord-023095-4dannjjm 3513 38 and and CC cord-023095-4dannjjm 3513 39 a a DT cord-023095-4dannjjm 3513 40 specificity specificity NN cord-023095-4dannjjm 3513 41 of of IN cord-023095-4dannjjm 3513 42 77.1 77.1 CD cord-023095-4dannjjm 3513 43 % % NN cord-023095-4dannjjm 3513 44 and and CC cord-023095-4dannjjm 3513 45 64.7 64.7 CD cord-023095-4dannjjm 3513 46 % % NN cord-023095-4dannjjm 3513 47 for for IN cord-023095-4dannjjm 3513 48 samples sample NNS cord-023095-4dannjjm 3513 49 from from IN cord-023095-4dannjjm 3513 50 FIV fiv NN cord-023095-4dannjjm 3513 51 - - HYPH cord-023095-4dannjjm 3513 52 seronegative seronegative JJ cord-023095-4dannjjm 3513 53 and and CC cord-023095-4dannjjm 3513 54 FIV fiv NN cord-023095-4dannjjm 3513 55 - - HYPH cord-023095-4dannjjm 3513 56 vaccinated vaccinate VBN cord-023095-4dannjjm 3513 57 cats cat NNS cord-023095-4dannjjm 3513 58 , , , cord-023095-4dannjjm 3513 59 respectively respectively RB cord-023095-4dannjjm 3513 60 . . . cord-023095-4dannjjm 3514 1 Conclusions conclusion NNS cord-023095-4dannjjm 3514 2 from from IN cord-023095-4dannjjm 3514 3 this this DT cord-023095-4dannjjm 3514 4 study study NN cord-023095-4dannjjm 3514 5 are be VBP cord-023095-4dannjjm 3514 6 1 1 CD cord-023095-4dannjjm 3514 7 ) ) -RRB- cord-023095-4dannjjm 3515 1 the the DT cord-023095-4dannjjm 3515 2 commercial commercial JJ cord-023095-4dannjjm 3515 3 FIV FIV NNP cord-023095-4dannjjm 3515 4 qPCR qpcr NN cord-023095-4dannjjm 3515 5 assay assay NN cord-023095-4dannjjm 3515 6 has have VBZ cord-023095-4dannjjm 3515 7 high high JJ cord-023095-4dannjjm 3515 8 specificity specificity NN cord-023095-4dannjjm 3515 9 but but CC cord-023095-4dannjjm 3515 10 limited limited JJ cord-023095-4dannjjm 3515 11 sensitivity sensitivity NN cord-023095-4dannjjm 3515 12 for for IN cord-023095-4dannjjm 3515 13 diagnosis diagnosis NN cord-023095-4dannjjm 3515 14 of of IN cord-023095-4dannjjm 3515 15 FIV FIV NNP cord-023095-4dannjjm 3515 16 infection infection NN cord-023095-4dannjjm 3515 17 ; ; : cord-023095-4dannjjm 3515 18 2 2 LS cord-023095-4dannjjm 3515 19 ) ) -RRB- cord-023095-4dannjjm 3515 20 7-day 7-day JJ cord-023095-4dannjjm 3515 21 virus virus NN cord-023095-4dannjjm 3515 22 culture culture NN cord-023095-4dannjjm 3515 23 has have VBZ cord-023095-4dannjjm 3515 24 limited limit VBN cord-023095-4dannjjm 3515 25 sensitivity sensitivity NN cord-023095-4dannjjm 3515 26 and and CC cord-023095-4dannjjm 3515 27 specificity specificity NN cord-023095-4dannjjm 3515 28 . . . cord-023095-4dannjjm 3516 1 Hence hence RB cord-023095-4dannjjm 3516 2 , , , cord-023095-4dannjjm 3516 3 detection detection NN cord-023095-4dannjjm 3516 4 of of IN cord-023095-4dannjjm 3516 5 antibodies antibody NNS cord-023095-4dannjjm 3516 6 remains remain VBZ cord-023095-4dannjjm 3516 7 the the DT cord-023095-4dannjjm 3516 8 most most RBS cord-023095-4dannjjm 3516 9 reliable reliable JJ cord-023095-4dannjjm 3516 10 test test NN cord-023095-4dannjjm 3516 11 for for IN cord-023095-4dannjjm 3516 12 diagnosis diagnosis NN cord-023095-4dannjjm 3516 13 of of IN cord-023095-4dannjjm 3516 14 FIV FIV NNP cord-023095-4dannjjm 3516 15 infection infection NN cord-023095-4dannjjm 3516 16 , , , cord-023095-4dannjjm 3516 17 but but CC cord-023095-4dannjjm 3516 18 qPCR qPCR NNP cord-023095-4dannjjm 3516 19 may may MD cord-023095-4dannjjm 3516 20 be be VB cord-023095-4dannjjm 3516 21 suitable suitable JJ cord-023095-4dannjjm 3516 22 to to TO cord-023095-4dannjjm 3516 23 rule rule VB cord-023095-4dannjjm 3516 24 out out RP cord-023095-4dannjjm 3516 25 infection infection NN cord-023095-4dannjjm 3516 26 . . . cord-023095-4dannjjm 3517 1 Oral oral JJ cord-023095-4dannjjm 3517 2 disease disease NN cord-023095-4dannjjm 3517 3 is be VBZ cord-023095-4dannjjm 3517 4 an an DT cord-023095-4dannjjm 3517 5 important important JJ cord-023095-4dannjjm 3517 6 clinical clinical JJ cord-023095-4dannjjm 3517 7 problem problem NN cord-023095-4dannjjm 3517 8 in in IN cord-023095-4dannjjm 3517 9 feline feline JJ cord-023095-4dannjjm 3517 10 medicine medicine NN cord-023095-4dannjjm 3517 11 and and CC cord-023095-4dannjjm 3517 12 includes include VBZ cord-023095-4dannjjm 3517 13 common common JJ cord-023095-4dannjjm 3517 14 painful painful JJ cord-023095-4dannjjm 3517 15 conditions condition NNS cord-023095-4dannjjm 3517 16 such such JJ cord-023095-4dannjjm 3517 17 as as IN cord-023095-4dannjjm 3517 18 oropharyngeal oropharyngeal JJ cord-023095-4dannjjm 3517 19 inflammation inflammation NN cord-023095-4dannjjm 3517 20 ( ( -LRB- cord-023095-4dannjjm 3517 21 formerly formerly RB cord-023095-4dannjjm 3517 22 known know VBN cord-023095-4dannjjm 3517 23 as as IN cord-023095-4dannjjm 3517 24 gingivostomatitis gingivostomatitis NNP cord-023095-4dannjjm 3517 25 ) ) -RRB- cord-023095-4dannjjm 3517 26 and and CC cord-023095-4dannjjm 3517 27 tooth tooth NN cord-023095-4dannjjm 3517 28 resorptive resorptive JJ cord-023095-4dannjjm 3517 29 lesions lesion NNS cord-023095-4dannjjm 3517 30 . . . cord-023095-4dannjjm 3518 1 A a DT cord-023095-4dannjjm 3518 2 number number NN cord-023095-4dannjjm 3518 3 of of IN cord-023095-4dannjjm 3518 4 infectious infectious JJ cord-023095-4dannjjm 3518 5 agents agent NNS cord-023095-4dannjjm 3518 6 have have VBP cord-023095-4dannjjm 3518 7 been be VBN cord-023095-4dannjjm 3518 8 associated associate VBN cord-023095-4dannjjm 3518 9 with with IN cord-023095-4dannjjm 3518 10 Private private JJ cord-023095-4dannjjm 3518 11 veterinary veterinary JJ cord-023095-4dannjjm 3518 12 clinics clinic NNS cord-023095-4dannjjm 3518 13 in in IN cord-023095-4dannjjm 3518 14 the the DT cord-023095-4dannjjm 3518 15 U.S. U.S. NNP cord-023095-4dannjjm 3518 16 were be VBD cord-023095-4dannjjm 3518 17 recruited recruit VBN cord-023095-4dannjjm 3518 18 to to TO cord-023095-4dannjjm 3518 19 test test VB cord-023095-4dannjjm 3518 20 feline feline JJ cord-023095-4dannjjm 3518 21 patients patient NNS cord-023095-4dannjjm 3518 22 presenting present VBG cord-023095-4dannjjm 3518 23 with with IN cord-023095-4dannjjm 3518 24 oral oral JJ cord-023095-4dannjjm 3518 25 disease disease NN cord-023095-4dannjjm 3518 26 . . . cord-023095-4dannjjm 3519 1 Presenting present VBG cord-023095-4dannjjm 3519 2 cases case NNS cord-023095-4dannjjm 3519 3 included include VBD cord-023095-4dannjjm 3519 4 cats cat NNS cord-023095-4dannjjm 3519 5 with with IN cord-023095-4dannjjm 3519 6 plaque plaque NN cord-023095-4dannjjm 3519 7 , , , cord-023095-4dannjjm 3519 8 calculus calculus NN cord-023095-4dannjjm 3519 9 , , , cord-023095-4dannjjm 3519 10 gingivitis gingivitis NN cord-023095-4dannjjm 3519 11 , , , cord-023095-4dannjjm 3519 12 stomatitis stomatitis NN cord-023095-4dannjjm 3519 13 , , , cord-023095-4dannjjm 3519 14 periodontal periodontal JJ cord-023095-4dannjjm 3519 15 disease disease NN cord-023095-4dannjjm 3519 16 , , , cord-023095-4dannjjm 3519 17 tooth tooth NN cord-023095-4dannjjm 3519 18 resorptive resorptive JJ cord-023095-4dannjjm 3519 19 lesions lesion NNS cord-023095-4dannjjm 3519 20 and and CC cord-023095-4dannjjm 3519 21 other other JJ cord-023095-4dannjjm 3519 22 oral oral JJ cord-023095-4dannjjm 3519 23 diseases disease NNS cord-023095-4dannjjm 3519 24 as as IN cord-023095-4dannjjm 3519 25 defined define VBN cord-023095-4dannjjm 3519 26 by by IN cord-023095-4dannjjm 3519 27 the the DT cord-023095-4dannjjm 3519 28 practitioner practitioner NN cord-023095-4dannjjm 3519 29 . . . cord-023095-4dannjjm 3520 1 All all DT cord-023095-4dannjjm 3520 2 cats cat NNS cord-023095-4dannjjm 3520 3 were be VBD cord-023095-4dannjjm 3520 4 tested test VBN cord-023095-4dannjjm 3520 5 using use VBG cord-023095-4dannjjm 3520 6 a a DT cord-023095-4dannjjm 3520 7 commercially commercially RB cord-023095-4dannjjm 3520 8 available available JJ cord-023095-4dannjjm 3520 9 point point NN cord-023095-4dannjjm 3520 10 - - HYPH cord-023095-4dannjjm 3520 11 of of IN cord-023095-4dannjjm 3520 12 - - HYPH cord-023095-4dannjjm 3520 13 care care NN cord-023095-4dannjjm 3520 14 ELISA ELISA NNP cord-023095-4dannjjm 3520 15 test test NN cord-023095-4dannjjm 3520 16 ( ( -LRB- cord-023095-4dannjjm 3520 17 IDEXX IDEXX NNP cord-023095-4dannjjm 3520 18 Snap Snap NNP cord-023095-4dannjjm 3520 19 Combo Combo NNP cord-023095-4dannjjm 3520 20 ) ) -RRB- cord-023095-4dannjjm 3520 21 . . . cord-023095-4dannjjm 3521 1 Confirmatory confirmatory JJ cord-023095-4dannjjm 3521 2 tests test NNS cord-023095-4dannjjm 3521 3 were be VBD cord-023095-4dannjjm 3521 4 not not RB cord-023095-4dannjjm 3521 5 performed perform VBN cord-023095-4dannjjm 3521 6 as as IN cord-023095-4dannjjm 3521 7 part part NN cord-023095-4dannjjm 3521 8 of of IN cord-023095-4dannjjm 3521 9 the the DT cord-023095-4dannjjm 3521 10 study study NN cord-023095-4dannjjm 3521 11 . . . cord-023095-4dannjjm 3522 1 Seroprevalence Seroprevalence NNP cord-023095-4dannjjm 3522 2 was be VBD cord-023095-4dannjjm 3522 3 calculated calculate VBN cord-023095-4dannjjm 3522 4 as as IN cord-023095-4dannjjm 3522 5 the the DT cord-023095-4dannjjm 3522 6 percentage percentage NN cord-023095-4dannjjm 3522 7 of of IN cord-023095-4dannjjm 3522 8 positive positive JJ cord-023095-4dannjjm 3522 9 tests test NNS cord-023095-4dannjjm 3522 10 in in IN cord-023095-4dannjjm 3522 11 the the DT cord-023095-4dannjjm 3522 12 study study NN cord-023095-4dannjjm 3522 13 population population NN cord-023095-4dannjjm 3522 14 for for IN cord-023095-4dannjjm 3522 15 each each DT cord-023095-4dannjjm 3522 16 virus virus NN cord-023095-4dannjjm 3522 17 . . . cord-023095-4dannjjm 3523 1 A a DT cord-023095-4dannjjm 3523 2 total total NN cord-023095-4dannjjm 3523 3 of of IN cord-023095-4dannjjm 3523 4 11,262 11,262 CD cord-023095-4dannjjm 3523 5 cats cat NNS cord-023095-4dannjjm 3523 6 were be VBD cord-023095-4dannjjm 3523 7 tested test VBN cord-023095-4dannjjm 3523 8 . . . cord-023095-4dannjjm 3524 1 Seroprevalence Seroprevalence NNP cord-023095-4dannjjm 3524 2 for for IN cord-023095-4dannjjm 3524 3 FeLV FeLV NNP cord-023095-4dannjjm 3524 4 was be VBD cord-023095-4dannjjm 3524 5 6.8 6.8 CD cord-023095-4dannjjm 3524 6 % % NN cord-023095-4dannjjm 3524 7 and and CC cord-023095-4dannjjm 3524 8 for for IN cord-023095-4dannjjm 3524 9 FIV FIV NNP cord-023095-4dannjjm 3524 10 was be VBD cord-023095-4dannjjm 3524 11 7.1 7.1 CD cord-023095-4dannjjm 3524 12 % % NN cord-023095-4dannjjm 3524 13 . . . cord-023095-4dannjjm 3525 1 Of of IN cord-023095-4dannjjm 3525 2 these these DT cord-023095-4dannjjm 3525 3 , , , cord-023095-4dannjjm 3525 4 119 119 CD cord-023095-4dannjjm 3525 5 cats cat NNS cord-023095-4dannjjm 3525 6 ( ( -LRB- cord-023095-4dannjjm 3525 7 1.0 1.0 CD cord-023095-4dannjjm 3525 8 % % NN cord-023095-4dannjjm 3525 9 ) ) -RRB- cord-023095-4dannjjm 3525 10 were be VBD cord-023095-4dannjjm 3525 11 infected infect VBN cord-023095-4dannjjm 3525 12 with with IN cord-023095-4dannjjm 3525 13 both both DT cord-023095-4dannjjm 3525 14 viruses virus NNS cord-023095-4dannjjm 3525 15 . . . cord-023095-4dannjjm 3526 1 Seroprevalence Seroprevalence NNP cord-023095-4dannjjm 3526 2 was be VBD cord-023095-4dannjjm 3526 3 higher high JJR cord-023095-4dannjjm 3526 4 in in IN cord-023095-4dannjjm 3526 5 cats cat NNS cord-023095-4dannjjm 3526 6 with with IN cord-023095-4dannjjm 3526 7 inflammatory inflammatory JJ cord-023095-4dannjjm 3526 8 oral oral JJ cord-023095-4dannjjm 3526 9 disease disease NN cord-023095-4dannjjm 3526 10 than than IN cord-023095-4dannjjm 3526 11 in in IN cord-023095-4dannjjm 3526 12 cats cat NNS cord-023095-4dannjjm 3526 13 characterized characterize VBN cord-023095-4dannjjm 3526 14 with with IN cord-023095-4dannjjm 3526 15 other other JJ cord-023095-4dannjjm 3526 16 types type NNS cord-023095-4dannjjm 3526 17 of of IN cord-023095-4dannjjm 3526 18 oral oral JJ cord-023095-4dannjjm 3526 19 disease disease NN cord-023095-4dannjjm 3526 20 . . . cord-023095-4dannjjm 3527 1 Of of IN cord-023095-4dannjjm 3527 2 7,805 7,805 CD cord-023095-4dannjjm 3527 3 cats cat NNS cord-023095-4dannjjm 3527 4 with with IN cord-023095-4dannjjm 3527 5 gingivitis gingivitis NN cord-023095-4dannjjm 3527 6 , , , cord-023095-4dannjjm 3527 7 seroprevalence seroprevalence NN cord-023095-4dannjjm 3527 8 for for IN cord-023095-4dannjjm 3527 9 FeLV FeLV NNP cord-023095-4dannjjm 3527 10 was be VBD cord-023095-4dannjjm 3527 11 7.4 7.4 CD cord-023095-4dannjjm 3527 12 % % NN cord-023095-4dannjjm 3527 13 and and CC cord-023095-4dannjjm 3527 14 for for IN cord-023095-4dannjjm 3527 15 FIV FIV NNP cord-023095-4dannjjm 3527 16 was be VBD cord-023095-4dannjjm 3527 17 7.9 7.9 CD cord-023095-4dannjjm 3527 18 % % NN cord-023095-4dannjjm 3527 19 , , , cord-023095-4dannjjm 3527 20 with with IN cord-023095-4dannjjm 3527 21 1.1 1.1 CD cord-023095-4dannjjm 3527 22 % % NN cord-023095-4dannjjm 3527 23 of of IN cord-023095-4dannjjm 3527 24 cats cat NNS cord-023095-4dannjjm 3527 25 co co VBP cord-023095-4dannjjm 3527 26 - - VBN cord-023095-4dannjjm 3527 27 infected infected JJ cord-023095-4dannjjm 3527 28 . . . cord-023095-4dannjjm 3528 1 Of of IN cord-023095-4dannjjm 3528 2 1,953 1,953 CD cord-023095-4dannjjm 3528 3 cats cat NNS cord-023095-4dannjjm 3528 4 with with IN cord-023095-4dannjjm 3528 5 stomatitis stomatitis NN cord-023095-4dannjjm 3528 6 , , , cord-023095-4dannjjm 3528 7 seroprevalence seroprevalence NN cord-023095-4dannjjm 3528 8 for for IN cord-023095-4dannjjm 3528 9 FeLV FeLV NNP cord-023095-4dannjjm 3528 10 was be VBD cord-023095-4dannjjm 3528 11 12.2 12.2 CD cord-023095-4dannjjm 3528 12 % % NN cord-023095-4dannjjm 3528 13 and and CC cord-023095-4dannjjm 3528 14 for for IN cord-023095-4dannjjm 3528 15 FIV FIV NNP cord-023095-4dannjjm 3528 16 was be VBD cord-023095-4dannjjm 3528 17 13.9 13.9 CD cord-023095-4dannjjm 3528 18 % % NN cord-023095-4dannjjm 3528 19 , , , cord-023095-4dannjjm 3528 20 with with IN cord-023095-4dannjjm 3528 21 2.2 2.2 CD cord-023095-4dannjjm 3528 22 % % NN cord-023095-4dannjjm 3528 23 of of IN cord-023095-4dannjjm 3528 24 cats cat NNS cord-023095-4dannjjm 3528 25 co co VBP cord-023095-4dannjjm 3528 26 - - VBN cord-023095-4dannjjm 3528 27 infected infected JJ cord-023095-4dannjjm 3528 28 . . . cord-023095-4dannjjm 3529 1 The the DT cord-023095-4dannjjm 3529 2 seroprevalence seroprevalence NN cord-023095-4dannjjm 3529 3 for for IN cord-023095-4dannjjm 3529 4 FeLV FeLV NNP cord-023095-4dannjjm 3529 5 and and CC cord-023095-4dannjjm 3529 6 FIV FIV NNP cord-023095-4dannjjm 3529 7 reported report VBN cord-023095-4dannjjm 3529 8 in in IN cord-023095-4dannjjm 3529 9 this this DT cord-023095-4dannjjm 3529 10 population population NN cord-023095-4dannjjm 3529 11 of of IN cord-023095-4dannjjm 3529 12 cats cat NNS cord-023095-4dannjjm 3529 13 with with IN cord-023095-4dannjjm 3529 14 oral oral JJ cord-023095-4dannjjm 3529 15 disease disease NN cord-023095-4dannjjm 3529 16 was be VBD cord-023095-4dannjjm 3529 17 higher high JJR cord-023095-4dannjjm 3529 18 than than IN cord-023095-4dannjjm 3529 19 in in IN cord-023095-4dannjjm 3529 20 a a DT cord-023095-4dannjjm 3529 21 recent recent JJ cord-023095-4dannjjm 3529 22 large large JJ cord-023095-4dannjjm 3529 23 study study NN cord-023095-4dannjjm 3529 24 where where WRB cord-023095-4dannjjm 3529 25 samples sample NNS cord-023095-4dannjjm 3529 26 from from IN cord-023095-4dannjjm 3529 27 U.S. U.S. NNP cord-023095-4dannjjm 3529 28 cats cat NNS cord-023095-4dannjjm 3529 29 not not RB cord-023095-4dannjjm 3529 30 specifically specifically RB cord-023095-4dannjjm 3529 31 selected select VBN cord-023095-4dannjjm 3529 32 for for IN cord-023095-4dannjjm 3529 33 oral oral JJ cord-023095-4dannjjm 3529 34 disease disease NN cord-023095-4dannjjm 3529 35 were be VBD cord-023095-4dannjjm 3529 36 tested test VBN cord-023095-4dannjjm 3529 37 ( ( -LRB- cord-023095-4dannjjm 3529 38 FeLV FeLV NNP cord-023095-4dannjjm 3529 39 2.3 2.3 CD cord-023095-4dannjjm 3529 40 % % NN cord-023095-4dannjjm 3529 41 , , , cord-023095-4dannjjm 3529 42 FIV FIV NNP cord-023095-4dannjjm 3529 43 2.5 2.5 CD cord-023095-4dannjjm 3529 44 % % NN cord-023095-4dannjjm 3529 45 ) ) -RRB- cord-023095-4dannjjm 3529 46 . . . cord-023095-4dannjjm 3530 1 Results result NNS cord-023095-4dannjjm 3530 2 of of IN cord-023095-4dannjjm 3530 3 this this DT cord-023095-4dannjjm 3530 4 study study NN cord-023095-4dannjjm 3530 5 indicate indicate VBP cord-023095-4dannjjm 3530 6 that that IN cord-023095-4dannjjm 3530 7 further further JJ cord-023095-4dannjjm 3530 8 investigation investigation NN cord-023095-4dannjjm 3530 9 of of IN cord-023095-4dannjjm 3530 10 the the DT cord-023095-4dannjjm 3530 11 role role NN cord-023095-4dannjjm 3530 12 of of IN cord-023095-4dannjjm 3530 13 retroviruses retrovirus NNS cord-023095-4dannjjm 3530 14 in in IN cord-023095-4dannjjm 3530 15 cats cat NNS cord-023095-4dannjjm 3530 16 with with IN cord-023095-4dannjjm 3530 17 oropharyngeal oropharyngeal JJ cord-023095-4dannjjm 3530 18 inflammation inflammation NN cord-023095-4dannjjm 3530 19 is be VBZ cord-023095-4dannjjm 3530 20 warranted warrant VBN cord-023095-4dannjjm 3530 21 . . . cord-023095-4dannjjm 3531 1 Reliable reliable JJ cord-023095-4dannjjm 3531 2 tests test NNS cord-023095-4dannjjm 3531 3 and and CC cord-023095-4dannjjm 3531 4 preventive preventive JJ cord-023095-4dannjjm 3531 5 vaccines vaccine NNS cord-023095-4dannjjm 3531 6 and and CC cord-023095-4dannjjm 3531 7 medications medication NNS cord-023095-4dannjjm 3531 8 for for IN cord-023095-4dannjjm 3531 9 feline feline JJ cord-023095-4dannjjm 3531 10 retroviral retroviral NN cord-023095-4dannjjm 3531 11 and and CC cord-023095-4dannjjm 3531 12 heartworm heartworm NN cord-023095-4dannjjm 3532 1 ( ( -LRB- cord-023095-4dannjjm 3532 2 HW HW NNP cord-023095-4dannjjm 3532 3 ) ) -RRB- cord-023095-4dannjjm 3532 4 infections infection NNS cord-023095-4dannjjm 3532 5 are be VBP cord-023095-4dannjjm 3532 6 available available JJ cord-023095-4dannjjm 3532 7 , , , cord-023095-4dannjjm 3532 8 but but CC cord-023095-4dannjjm 3532 9 compliance compliance NN cord-023095-4dannjjm 3532 10 with with IN cord-023095-4dannjjm 3532 11 protocols protocol NNS cord-023095-4dannjjm 3532 12 to to TO cord-023095-4dannjjm 3532 13 reduce reduce VB cord-023095-4dannjjm 3532 14 transmission transmission NN cord-023095-4dannjjm 3532 15 is be VBZ cord-023095-4dannjjm 3532 16 unknown unknown JJ cord-023095-4dannjjm 3532 17 . . . cord-023095-4dannjjm 3533 1 No no DT cord-023095-4dannjjm 3533 2 largescale largescale JJ cord-023095-4dannjjm 3533 3 longitudinal longitudinal JJ cord-023095-4dannjjm 3533 4 studies study NNS cord-023095-4dannjjm 3533 5 evaluating evaluate VBG cord-023095-4dannjjm 3533 6 prevalence prevalence NN cord-023095-4dannjjm 3533 7 over over IN cord-023095-4dannjjm 3533 8 time time NN cord-023095-4dannjjm 3533 9 have have VBP cord-023095-4dannjjm 3533 10 been be VBN cord-023095-4dannjjm 3533 11 reported report VBN cord-023095-4dannjjm 3533 12 . . . cord-023095-4dannjjm 3534 1 The the DT cord-023095-4dannjjm 3534 2 purpose purpose NN cord-023095-4dannjjm 3534 3 of of IN cord-023095-4dannjjm 3534 4 this this DT cord-023095-4dannjjm 3534 5 study study NN cord-023095-4dannjjm 3534 6 was be VBD cord-023095-4dannjjm 3534 7 to to TO cord-023095-4dannjjm 3534 8 determine determine VB cord-023095-4dannjjm 3534 9 the the DT cord-023095-4dannjjm 3534 10 prevalence prevalence NN cord-023095-4dannjjm 3534 11 and and CC cord-023095-4dannjjm 3534 12 risk risk NN cord-023095-4dannjjm 3534 13 factors factor NNS cord-023095-4dannjjm 3534 14 for for IN cord-023095-4dannjjm 3534 15 infection infection NN cord-023095-4dannjjm 3534 16 compared compare VBN cord-023095-4dannjjm 3534 17 with with IN cord-023095-4dannjjm 3534 18 a a DT cord-023095-4dannjjm 3534 19 similar similar JJ cord-023095-4dannjjm 3534 20 study study NN cord-023095-4dannjjm 3534 21 completed complete VBN cord-023095-4dannjjm 3534 22 for for IN cord-023095-4dannjjm 3534 23 the the DT cord-023095-4dannjjm 3534 24 first first JJ cord-023095-4dannjjm 3534 25 time time NN cord-023095-4dannjjm 3534 26 5 5 CD cord-023095-4dannjjm 3534 27 years year NNS cord-023095-4dannjjm 3534 28 previously previously RB cord-023095-4dannjjm 3534 29 . . . cord-023095-4dannjjm 3535 1 Veterinary veterinary JJ cord-023095-4dannjjm 3535 2 clinics clinic NNS cord-023095-4dannjjm 3535 3 and and CC cord-023095-4dannjjm 3535 4 animal animal NN cord-023095-4dannjjm 3535 5 shelters shelter NNS cord-023095-4dannjjm 3535 6 in in IN cord-023095-4dannjjm 3535 7 the the DT cord-023095-4dannjjm 3535 8 US US NNP cord-023095-4dannjjm 3535 9 and and CC cord-023095-4dannjjm 3535 10 Canada Canada NNP cord-023095-4dannjjm 3535 11 submitted submit VBD cord-023095-4dannjjm 3535 12 results result NNS cord-023095-4dannjjm 3535 13 of of IN cord-023095-4dannjjm 3535 14 testing testing NN cord-023095-4dannjjm 3535 15 using use VBG cord-023095-4dannjjm 3535 16 a a DT cord-023095-4dannjjm 3535 17 point point NN cord-023095-4dannjjm 3535 18 - - HYPH cord-023095-4dannjjm 3535 19 of of IN cord-023095-4dannjjm 3535 20 - - HYPH cord-023095-4dannjjm 3535 21 care care NN cord-023095-4dannjjm 3535 22 ELISA ELISA NNP cord-023095-4dannjjm 3535 23 for for IN cord-023095-4dannjjm 3535 24 FeLV FeLV NNP cord-023095-4dannjjm 3535 25 antigen antigen NN cord-023095-4dannjjm 3535 26 , , , cord-023095-4dannjjm 3535 27 FIV FIV NNP cord-023095-4dannjjm 3535 28 antibody antibody NN cord-023095-4dannjjm 3535 29 , , , cord-023095-4dannjjm 3535 30 and and CC cord-023095-4dannjjm 3535 31 HW HW NNP cord-023095-4dannjjm 3535 32 antigen antigen NN cord-023095-4dannjjm 3535 33 ( ( -LRB- cord-023095-4dannjjm 3536 1 IDEXX IDEXX NNP cord-023095-4dannjjm 3536 2 SNAP SNAP NNP cord-023095-4dannjjm 3536 3 Triple Triple NNP cord-023095-4dannjjm 3536 4 ) ) -RRB- cord-023095-4dannjjm 3536 5 and and CC cord-023095-4dannjjm 3536 6 risk risk NN cord-023095-4dannjjm 3536 7 factor factor NN cord-023095-4dannjjm 3536 8 information information NN cord-023095-4dannjjm 3536 9 for for IN cord-023095-4dannjjm 3536 10 cats cat NNS cord-023095-4dannjjm 3536 11 tested test VBN cord-023095-4dannjjm 3536 12 during during IN cord-023095-4dannjjm 3536 13 March March NNP cord-023095-4dannjjm 3536 14 - - HYPH cord-023095-4dannjjm 3536 15 September September NNP cord-023095-4dannjjm 3536 16 2010 2010 CD cord-023095-4dannjjm 3536 17 . . . cord-023095-4dannjjm 3537 1 Bivariable bivariable JJ cord-023095-4dannjjm 3537 2 and and CC cord-023095-4dannjjm 3537 3 multivariable multivariable JJ cord-023095-4dannjjm 3537 4 analyses analysis NNS cord-023095-4dannjjm 3537 5 were be VBD cord-023095-4dannjjm 3537 6 used use VBN cord-023095-4dannjjm 3537 7 to to TO cord-023095-4dannjjm 3537 8 evaluate evaluate VB cord-023095-4dannjjm 3537 9 risk risk NN cord-023095-4dannjjm 3537 10 factors factor NNS cord-023095-4dannjjm 3537 11 for for IN cord-023095-4dannjjm 3537 12 infections infection NNS cord-023095-4dannjjm 3537 13 . . . cord-023095-4dannjjm 3538 1 A a DT cord-023095-4dannjjm 3538 2 total total NN cord-023095-4dannjjm 3538 3 of of IN cord-023095-4dannjjm 3538 4 62,301 62,301 CD cord-023095-4dannjjm 3538 5 cats cat NNS cord-023095-4dannjjm 3538 6 were be VBD cord-023095-4dannjjm 3538 7 tested test VBN cord-023095-4dannjjm 3538 8 . . . cord-023095-4dannjjm 3539 1 Only only RB cord-023095-4dannjjm 3539 2 16 16 CD cord-023095-4dannjjm 3539 3 % % NN cord-023095-4dannjjm 3539 4 of of IN cord-023095-4dannjjm 3539 5 owned own VBN cord-023095-4dannjjm 3539 6 cats cat NNS cord-023095-4dannjjm 3539 7 were be VBD cord-023095-4dannjjm 3539 8 prescribed prescribe VBN cord-023095-4dannjjm 3539 9 HW HW NNP cord-023095-4dannjjm 3539 10 preventive preventive JJ cord-023095-4dannjjm 3539 11 . . . cord-023095-4dannjjm 3540 1 Risk risk NN cord-023095-4dannjjm 3540 2 of of IN cord-023095-4dannjjm 3540 3 retroviral retroviral JJ cord-023095-4dannjjm 3540 4 infections infection NNS cord-023095-4dannjjm 3540 5 was be VBD cord-023095-4dannjjm 3540 6 increased increase VBN cord-023095-4dannjjm 3540 7 by by IN cord-023095-4dannjjm 3540 8 outdoor outdoor JJ cord-023095-4dannjjm 3540 9 access access NN cord-023095-4dannjjm 3540 10 , , , cord-023095-4dannjjm 3540 11 adulthood adulthood NN cord-023095-4dannjjm 3540 12 , , , cord-023095-4dannjjm 3540 13 and and CC cord-023095-4dannjjm 3540 14 male male JJ cord-023095-4dannjjm 3540 15 gender gender NN cord-023095-4dannjjm 3540 16 . . . cord-023095-4dannjjm 3541 1 The the DT cord-023095-4dannjjm 3541 2 most most RBS cord-023095-4dannjjm 3541 3 important important JJ cord-023095-4dannjjm 3541 4 risk risk NN cord-023095-4dannjjm 3541 5 factor factor NN cord-023095-4dannjjm 3541 6 associated associate VBN cord-023095-4dannjjm 3541 7 with with IN cord-023095-4dannjjm 3541 8 all all DT cord-023095-4dannjjm 3541 9 3 3 CD cord-023095-4dannjjm 3541 10 infections infection NNS cord-023095-4dannjjm 3541 11 was be VBD cord-023095-4dannjjm 3541 12 clinical clinical JJ cord-023095-4dannjjm 3541 13 disease disease NN cord-023095-4dannjjm 3541 14 ; ; : cord-023095-4dannjjm 3541 15 in in IN cord-023095-4dannjjm 3541 16 particular particular JJ cord-023095-4dannjjm 3541 17 , , , cord-023095-4dannjjm 3541 18 respiratory respiratory JJ cord-023095-4dannjjm 3541 19 and and CC cord-023095-4dannjjm 3541 20 oral oral JJ cord-023095-4dannjjm 3541 21 diseases disease NNS cord-023095-4dannjjm 3541 22 and and CC cord-023095-4dannjjm 3541 23 abscesses abscess NNS cord-023095-4dannjjm 3541 24 or or CC cord-023095-4dannjjm 3541 25 bite bite NN cord-023095-4dannjjm 3541 26 wounds wound NNS cord-023095-4dannjjm 3541 27 . . . cord-023095-4dannjjm 3542 1 Multivariate multivariate JJ cord-023095-4dannjjm 3542 2 analysis analysis NN cord-023095-4dannjjm 3542 3 revealed reveal VBD cord-023095-4dannjjm 3542 4 differences difference NNS cord-023095-4dannjjm 3542 5 among among IN cord-023095-4dannjjm 3542 6 geodivisions geodivision NNS cord-023095-4dannjjm 3542 7 and and CC cord-023095-4dannjjm 3542 8 across across IN cord-023095-4dannjjm 3542 9 infection infection NN cord-023095-4dannjjm 3542 10 types type NNS cord-023095-4dannjjm 3542 11 . . . cord-023095-4dannjjm 3543 1 Feline feline JJ cord-023095-4dannjjm 3543 2 retroviral retroviral NN cord-023095-4dannjjm 3543 3 and and CC cord-023095-4dannjjm 3543 4 heartworm heartworm NN cord-023095-4dannjjm 3543 5 infections infection NNS cord-023095-4dannjjm 3543 6 are be VBP cord-023095-4dannjjm 3543 7 easily easily RB cord-023095-4dannjjm 3543 8 prevented prevent VBN cord-023095-4dannjjm 3543 9 , , , cord-023095-4dannjjm 3543 10 but but CC cord-023095-4dannjjm 3543 11 difficult difficult JJ cord-023095-4dannjjm 3543 12 to to TO cord-023095-4dannjjm 3543 13 treat treat VB cord-023095-4dannjjm 3543 14 . . . cord-023095-4dannjjm 3544 1 Despite despite IN cord-023095-4dannjjm 3544 2 availability availability NN cord-023095-4dannjjm 3544 3 of of IN cord-023095-4dannjjm 3544 4 effective effective JJ cord-023095-4dannjjm 3544 5 management management NN cord-023095-4dannjjm 3544 6 protocols protocol NNS cord-023095-4dannjjm 3544 7 , , , cord-023095-4dannjjm 3544 8 compliance compliance NN cord-023095-4dannjjm 3544 9 remains remain VBZ cord-023095-4dannjjm 3544 10 inadequate inadequate JJ cord-023095-4dannjjm 3544 11 to to TO cord-023095-4dannjjm 3544 12 reduce reduce VB cord-023095-4dannjjm 3544 13 the the DT cord-023095-4dannjjm 3544 14 prevalence prevalence NN cord-023095-4dannjjm 3544 15 of of IN cord-023095-4dannjjm 3544 16 these these DT cord-023095-4dannjjm 3544 17 infections infection NNS cord-023095-4dannjjm 3544 18 . . . cord-023095-4dannjjm 3545 1 Improved improve VBN cord-023095-4dannjjm 3545 2 use use NN cord-023095-4dannjjm 3545 3 of of IN cord-023095-4dannjjm 3545 4 preventive preventive JJ cord-023095-4dannjjm 3545 5 care care NN cord-023095-4dannjjm 3545 6 and and CC cord-023095-4dannjjm 3545 7 testing testing NN cord-023095-4dannjjm 3545 8 to to TO cord-023095-4dannjjm 3545 9 identify identify VB cord-023095-4dannjjm 3545 10 and and CC cord-023095-4dannjjm 3545 11 segregate segregate VB cord-023095-4dannjjm 3545 12 contagious contagious JJ cord-023095-4dannjjm 3545 13 cats cat NNS cord-023095-4dannjjm 3545 14 , , , cord-023095-4dannjjm 3545 15 particularly particularly RB cord-023095-4dannjjm 3545 16 those those DT cord-023095-4dannjjm 3545 17 at at IN cord-023095-4dannjjm 3545 18 high high JJ cord-023095-4dannjjm 3545 19 - - HYPH cord-023095-4dannjjm 3545 20 risk risk NN cord-023095-4dannjjm 3545 21 , , , cord-023095-4dannjjm 3545 22 is be VBZ cord-023095-4dannjjm 3545 23 required require VBN cord-023095-4dannjjm 3545 24 to to TO cord-023095-4dannjjm 3545 25 reduce reduce VB cord-023095-4dannjjm 3545 26 the the DT cord-023095-4dannjjm 3545 27 morbidity morbidity NN cord-023095-4dannjjm 3545 28 of of IN cord-023095-4dannjjm 3545 29 these these DT cord-023095-4dannjjm 3545 30 preventable preventable JJ cord-023095-4dannjjm 3545 31 infections infection NNS cord-023095-4dannjjm 3545 32 . . . cord-023095-4dannjjm 3546 1 Infectious infectious JJ cord-023095-4dannjjm 3546 2 disease disease NN cord-023095-4dannjjm 3546 3 outbreaks outbreak NNS cord-023095-4dannjjm 3546 4 are be VBP cord-023095-4dannjjm 3546 5 common common JJ cord-023095-4dannjjm 3546 6 in in IN cord-023095-4dannjjm 3546 7 animal animal NN cord-023095-4dannjjm 3546 8 shelters shelter NNS cord-023095-4dannjjm 3546 9 and and CC cord-023095-4dannjjm 3546 10 are be VBP cord-023095-4dannjjm 3546 11 frequently frequently RB cord-023095-4dannjjm 3546 12 managed manage VBN cord-023095-4dannjjm 3546 13 by by IN cord-023095-4dannjjm 3546 14 depopulation depopulation NN cord-023095-4dannjjm 3546 15 when when WRB cord-023095-4dannjjm 3546 16 risk risk NN cord-023095-4dannjjm 3546 17 - - HYPH cord-023095-4dannjjm 3546 18 assessment assessment NN cord-023095-4dannjjm 3546 19 tools tool NNS cord-023095-4dannjjm 3546 20 are be VBP cord-023095-4dannjjm 3546 21 not not RB cord-023095-4dannjjm 3546 22 available available JJ cord-023095-4dannjjm 3546 23 . . . cord-023095-4dannjjm 3547 1 During during IN cord-023095-4dannjjm 3547 2 a a DT cord-023095-4dannjjm 3547 3 canine canine JJ cord-023095-4dannjjm 3547 4 distemper distemper NN cord-023095-4dannjjm 3547 5 virus virus NN cord-023095-4dannjjm 3547 6 ( ( -LRB- cord-023095-4dannjjm 3547 7 CDV CDV NNP cord-023095-4dannjjm 3547 8 ) ) -RRB- cord-023095-4dannjjm 3547 9 and and CC cord-023095-4dannjjm 3547 10 parvovirus parvovirus NN cord-023095-4dannjjm 3547 11 ( ( -LRB- cord-023095-4dannjjm 3547 12 CPV CPV NNP cord-023095-4dannjjm 3547 13 ) ) -RRB- cord-023095-4dannjjm 3547 14 outbreak outbreak NN cord-023095-4dannjjm 3547 15 in in IN cord-023095-4dannjjm 3547 16 sheltered sheltered JJ cord-023095-4dannjjm 3547 17 dogs dog NNS cord-023095-4dannjjm 3547 18 , , , cord-023095-4dannjjm 3547 19 we -PRON- PRP cord-023095-4dannjjm 3547 20 used use VBD cord-023095-4dannjjm 3547 21 a a DT cord-023095-4dannjjm 3547 22 CDV CDV NNP cord-023095-4dannjjm 3547 23 / / SYM cord-023095-4dannjjm 3547 24 CPV cpv NN cord-023095-4dannjjm 3547 25 point point NN cord-023095-4dannjjm 3547 26 - - HYPH cord-023095-4dannjjm 3547 27 of of IN cord-023095-4dannjjm 3547 28 - - HYPH cord-023095-4dannjjm 3547 29 care care NN cord-023095-4dannjjm 3547 30 antibody antibody NN cord-023095-4dannjjm 3547 31 titer titer NN cord-023095-4dannjjm 3547 32 ELISA ELISA NNP cord-023095-4dannjjm 3547 33 , , , cord-023095-4dannjjm 3547 34 a a DT cord-023095-4dannjjm 3547 35 CDV CDV NNP cord-023095-4dannjjm 3547 36 quantitative quantitative JJ cord-023095-4dannjjm 3547 37 RT rt NN cord-023095-4dannjjm 3547 38 - - HYPH cord-023095-4dannjjm 3547 39 PCR PCR NNP cord-023095-4dannjjm 3547 40 test test NN cord-023095-4dannjjm 3547 41 , , , cord-023095-4dannjjm 3547 42 and and CC cord-023095-4dannjjm 3547 43 a a DT cord-023095-4dannjjm 3547 44 CPV cpv JJ cord-023095-4dannjjm 3547 45 fecal fecal JJ cord-023095-4dannjjm 3547 46 antigen antigen NN cord-023095-4dannjjm 3547 47 test test NN cord-023095-4dannjjm 3547 48 as as IN cord-023095-4dannjjm 3547 49 risk risk NN cord-023095-4dannjjm 3547 50 assessment assessment NN cord-023095-4dannjjm 3547 51 tools tool NNS cord-023095-4dannjjm 3547 52 to to TO cord-023095-4dannjjm 3547 53 guide guide VB cord-023095-4dannjjm 3547 54 release release NN cord-023095-4dannjjm 3547 55 of of IN cord-023095-4dannjjm 3547 56 exposed expose VBN cord-023095-4dannjjm 3547 57 dogs dog NNS cord-023095-4dannjjm 3547 58 from from IN cord-023095-4dannjjm 3547 59 quarantine quarantine NN cord-023095-4dannjjm 3547 60 and and CC cord-023095-4dannjjm 3547 61 euthanasia euthanasia NN cord-023095-4dannjjm 3547 62 of of IN cord-023095-4dannjjm 3547 63 diseased diseased JJ cord-023095-4dannjjm 3547 64 dogs dog NNS cord-023095-4dannjjm 3547 65 . . . cord-023095-4dannjjm 3548 1 Serum serum NN cord-023095-4dannjjm 3548 2 samples sample NNS cord-023095-4dannjjm 3548 3 ( ( -LRB- cord-023095-4dannjjm 3548 4 for for IN cord-023095-4dannjjm 3548 5 antibody antibody NN cord-023095-4dannjjm 3548 6 titers titer NNS cord-023095-4dannjjm 3548 7 ) ) -RRB- cord-023095-4dannjjm 3548 8 and and CC cord-023095-4dannjjm 3548 9 swabs swab NNS cord-023095-4dannjjm 3548 10 of of IN cord-023095-4dannjjm 3548 11 the the DT cord-023095-4dannjjm 3548 12 conjunctiva conjunctiva NN cord-023095-4dannjjm 3548 13 and and CC cord-023095-4dannjjm 3548 14 upper upper JJ cord-023095-4dannjjm 3548 15 respiratory respiratory JJ cord-023095-4dannjjm 3548 16 tract tract NN cord-023095-4dannjjm 3548 17 ( ( -LRB- cord-023095-4dannjjm 3548 18 for for IN cord-023095-4dannjjm 3548 19 CDV CDV NNP cord-023095-4dannjjm 3548 20 PCR PCR NNP cord-023095-4dannjjm 3548 21 ) ) -RRB- cord-023095-4dannjjm 3548 22 were be VBD cord-023095-4dannjjm 3548 23 collected collect VBN cord-023095-4dannjjm 3548 24 from from IN cord-023095-4dannjjm 3548 25 111 111 CD cord-023095-4dannjjm 3548 26 asymptomatic asymptomatic JJ cord-023095-4dannjjm 3548 27 dogs dog NNS cord-023095-4dannjjm 3548 28 starting start VBG cord-023095-4dannjjm 3548 29 on on IN cord-023095-4dannjjm 3548 30 Day Day NNP cord-023095-4dannjjm 3548 31 4 4 CD cord-023095-4dannjjm 3548 32 of of IN cord-023095-4dannjjm 3548 33 the the DT cord-023095-4dannjjm 3548 34 outbreak outbreak NN cord-023095-4dannjjm 3548 35 . . . cord-023095-4dannjjm 3549 1 Dogs dog NNS cord-023095-4dannjjm 3549 2 with with IN cord-023095-4dannjjm 3549 3 positive positive JJ cord-023095-4dannjjm 3549 4 CDV CDV NNP cord-023095-4dannjjm 3549 5 PCR PCR NNP cord-023095-4dannjjm 3549 6 tests test NNS cord-023095-4dannjjm 3549 7 were be VBD cord-023095-4dannjjm 3549 8 retested reteste VBN cord-023095-4dannjjm 3549 9 every every DT cord-023095-4dannjjm 3549 10 2 2 CD cord-023095-4dannjjm 3549 11 weeks week NNS cord-023095-4dannjjm 3549 12 until until IN cord-023095-4dannjjm 3549 13 euthanized euthanize VBN cord-023095-4dannjjm 3549 14 for for IN cord-023095-4dannjjm 3549 15 progressive progressive JJ cord-023095-4dannjjm 3549 16 disease disease NN cord-023095-4dannjjm 3549 17 or or CC cord-023095-4dannjjm 3549 18 released release VBN cord-023095-4dannjjm 3549 19 following follow VBG cord-023095-4dannjjm 3549 20 recovery recovery NN cord-023095-4dannjjm 3549 21 from from IN cord-023095-4dannjjm 3549 22 infection infection NN cord-023095-4dannjjm 3549 23 . . . cord-023095-4dannjjm 3550 1 Dogs dog NNS cord-023095-4dannjjm 3550 2 with with IN cord-023095-4dannjjm 3550 3 clinical clinical JJ cord-023095-4dannjjm 3550 4 signs sign NNS cord-023095-4dannjjm 3550 5 of of IN cord-023095-4dannjjm 3550 6 parvoviral parvoviral JJ cord-023095-4dannjjm 3550 7 infection infection NN cord-023095-4dannjjm 3550 8 were be VBD cord-023095-4dannjjm 3550 9 tested test VBN cord-023095-4dannjjm 3550 10 using use VBG cord-023095-4dannjjm 3550 11 a a DT cord-023095-4dannjjm 3550 12 CPV CPV NNP cord-023095-4dannjjm 3550 13 fecal fecal JJ cord-023095-4dannjjm 3550 14 antigen antigen NN cord-023095-4dannjjm 3550 15 test test NN cord-023095-4dannjjm 3550 16 . . . cord-023095-4dannjjm 3551 1 For for IN cord-023095-4dannjjm 3551 2 dogs dog NNS cord-023095-4dannjjm 3551 3 ! ! . cord-023095-4dannjjm 3551 4 4 4 CD cord-023095-4dannjjm 3551 5 months month NNS cord-023095-4dannjjm 3551 6 old old JJ cord-023095-4dannjjm 3551 7 , , , cord-023095-4dannjjm 3551 8 protective protective JJ cord-023095-4dannjjm 3551 9 antibody antibody NN cord-023095-4dannjjm 3551 10 titers titer NNS cord-023095-4dannjjm 3551 11 correlated correlate VBD cord-023095-4dannjjm 3551 12 with with IN cord-023095-4dannjjm 3551 13 resistance resistance NN cord-023095-4dannjjm 3551 14 to to IN cord-023095-4dannjjm 3551 15 clinical clinical JJ cord-023095-4dannjjm 3551 16 disease disease NN cord-023095-4dannjjm 3551 17 , , , cord-023095-4dannjjm 3551 18 but but CC cord-023095-4dannjjm 3551 19 10 10 CD cord-023095-4dannjjm 3551 20 % % NN cord-023095-4dannjjm 3551 21 of of IN cord-023095-4dannjjm 3551 22 dogs dog NNS cord-023095-4dannjjm 3551 23 shed shed VBD cord-023095-4dannjjm 3551 24 CDV CDV NNP cord-023095-4dannjjm 3551 25 . . . cord-023095-4dannjjm 3552 1 Lack lack NN cord-023095-4dannjjm 3552 2 of of IN cord-023095-4dannjjm 3552 3 protective protective JJ cord-023095-4dannjjm 3552 4 CDV CDV NNP cord-023095-4dannjjm 3552 5 antibody antibody NN cord-023095-4dannjjm 3552 6 titers titer NNS cord-023095-4dannjjm 3552 7 correlated correlate VBD cord-023095-4dannjjm 3552 8 with with IN cord-023095-4dannjjm 3552 9 susceptibility susceptibility NN cord-023095-4dannjjm 3552 10 to to IN cord-023095-4dannjjm 3552 11 clinical clinical JJ cord-023095-4dannjjm 3552 12 infection infection NN cord-023095-4dannjjm 3552 13 , , , cord-023095-4dannjjm 3552 14 but but CC cord-023095-4dannjjm 3552 15 most most JJS cord-023095-4dannjjm 3552 16 dogs dog NNS cord-023095-4dannjjm 3552 17 recovered recover VBD cord-023095-4dannjjm 3552 18 . . . cord-023095-4dannjjm 3553 1 Risk risk NN cord-023095-4dannjjm 3553 2 assessment assessment NN cord-023095-4dannjjm 3553 3 and and CC cord-023095-4dannjjm 3553 4 outcome outcome NN cord-023095-4dannjjm 3553 5 in in IN cord-023095-4dannjjm 3553 6 60 60 CD cord-023095-4dannjjm 3553 7 dogs dog NNS cord-023095-4dannjjm 3553 8 ! ! . cord-023095-4dannjjm 3554 1 4 4 CD cord-023095-4dannjjm 3554 2 months month NNS cord-023095-4dannjjm 3554 3 of of IN cord-023095-4dannjjm 3554 4 age age NN cord-023095-4dannjjm 3554 5 Feline feline JJ cord-023095-4dannjjm 3554 6 herpesvirus herpesvirus NN cord-023095-4dannjjm 3554 7 1 1 CD cord-023095-4dannjjm 3554 8 ( ( -LRB- cord-023095-4dannjjm 3554 9 FHV-1 FHV-1 NNP cord-023095-4dannjjm 3554 10 ) ) -RRB- cord-023095-4dannjjm 3554 11 is be VBZ cord-023095-4dannjjm 3554 12 a a DT cord-023095-4dannjjm 3554 13 common common JJ cord-023095-4dannjjm 3554 14 ocular ocular JJ cord-023095-4dannjjm 3554 15 and and CC cord-023095-4dannjjm 3554 16 respiratory respiratory JJ cord-023095-4dannjjm 3554 17 pathogen pathogen NN cord-023095-4dannjjm 3554 18 of of IN cord-023095-4dannjjm 3554 19 cats cat NNS cord-023095-4dannjjm 3554 20 that that WDT cord-023095-4dannjjm 3554 21 can can MD cord-023095-4dannjjm 3554 22 have have VB cord-023095-4dannjjm 3554 23 clinical clinical JJ cord-023095-4dannjjm 3554 24 illness illness NN cord-023095-4dannjjm 3554 25 exacerbated exacerbate VBN cord-023095-4dannjjm 3554 26 by by IN cord-023095-4dannjjm 3554 27 stress stress NN cord-023095-4dannjjm 3554 28 . . . cord-023095-4dannjjm 3555 1 Cyclosporine cyclosporine NN cord-023095-4dannjjm 3555 2 ( ( -LRB- cord-023095-4dannjjm 3555 3 CsA CsA NNP cord-023095-4dannjjm 3555 4 ) ) -RRB- cord-023095-4dannjjm 3555 5 is be VBZ cord-023095-4dannjjm 3555 6 commonly commonly RB cord-023095-4dannjjm 3555 7 used use VBN cord-023095-4dannjjm 3555 8 for for IN cord-023095-4dannjjm 3555 9 the the DT cord-023095-4dannjjm 3555 10 treatment treatment NN cord-023095-4dannjjm 3555 11 of of IN cord-023095-4dannjjm 3555 12 a a DT cord-023095-4dannjjm 3555 13 number number NN cord-023095-4dannjjm 3555 14 of of IN cord-023095-4dannjjm 3555 15 inflammatory inflammatory JJ cord-023095-4dannjjm 3555 16 diseases disease NNS cord-023095-4dannjjm 3555 17 in in IN cord-023095-4dannjjm 3555 18 cats cat NNS cord-023095-4dannjjm 3555 19 and and CC cord-023095-4dannjjm 3555 20 can can MD cord-023095-4dannjjm 3555 21 induce induce VB cord-023095-4dannjjm 3555 22 immune immune JJ cord-023095-4dannjjm 3555 23 suppression suppression NN cord-023095-4dannjjm 3555 24 . . . cord-023095-4dannjjm 3556 1 A a DT cord-023095-4dannjjm 3556 2 small small JJ cord-023095-4dannjjm 3556 3 number number NN cord-023095-4dannjjm 3556 4 of of IN cord-023095-4dannjjm 3556 5 cats cat NNS cord-023095-4dannjjm 3556 6 administered administer VBD cord-023095-4dannjjm 3556 7 CsA CsA NNP cord-023095-4dannjjm 3556 8 to to TO cord-023095-4dannjjm 3556 9 block block VB cord-023095-4dannjjm 3556 10 renal renal JJ cord-023095-4dannjjm 3556 11 transplant transplant NN cord-023095-4dannjjm 3556 12 rejection rejection NN cord-023095-4dannjjm 3556 13 have have VBP cord-023095-4dannjjm 3556 14 developed develop VBN cord-023095-4dannjjm 3556 15 clinical clinical JJ cord-023095-4dannjjm 3556 16 signs sign NNS cord-023095-4dannjjm 3556 17 of of IN cord-023095-4dannjjm 3556 18 upper upper JJ cord-023095-4dannjjm 3556 19 respiratory respiratory JJ cord-023095-4dannjjm 3556 20 tract tract NN cord-023095-4dannjjm 3556 21 disease disease NN cord-023095-4dannjjm 3556 22 that that WDT cord-023095-4dannjjm 3556 23 may may MD cord-023095-4dannjjm 3556 24 have have VB cord-023095-4dannjjm 3556 25 been be VBN cord-023095-4dannjjm 3556 26 from from IN cord-023095-4dannjjm 3556 27 activated activate VBN cord-023095-4dannjjm 3556 28 FHV-1 FHV-1 NNP cord-023095-4dannjjm 3556 29 . . . cord-023095-4dannjjm 3557 1 In in IN cord-023095-4dannjjm 3557 2 this this DT cord-023095-4dannjjm 3557 3 study study NN cord-023095-4dannjjm 3557 4 , , , cord-023095-4dannjjm 3557 5 young young JJ cord-023095-4dannjjm 3557 6 adult adult NN cord-023095-4dannjjm 3557 7 cats cat NNS cord-023095-4dannjjm 3557 8 experimentally experimentally RB cord-023095-4dannjjm 3557 9 inoculated inoculate VBD cord-023095-4dannjjm 3557 10 with with IN cord-023095-4dannjjm 3557 11 FHV-1 FHV-1 NNP cord-023095-4dannjjm 3557 12 several several JJ cord-023095-4dannjjm 3557 13 months month NNS cord-023095-4dannjjm 3557 14 previously previously RB cord-023095-4dannjjm 3557 15 were be VBD cord-023095-4dannjjm 3557 16 divided divide VBN cord-023095-4dannjjm 3557 17 into into IN cord-023095-4dannjjm 3557 18 three three CD cord-023095-4dannjjm 3557 19 groups group NNS cord-023095-4dannjjm 3557 20 and and CC cord-023095-4dannjjm 3557 21 administered administer VBN cord-023095-4dannjjm 3557 22 methylprednisolone methylprednisolone NN cord-023095-4dannjjm 3557 23 acetate acetate NN cord-023095-4dannjjm 3557 24 ( ( -LRB- cord-023095-4dannjjm 3557 25 8 8 CD cord-023095-4dannjjm 3557 26 cats cat NNS cord-023095-4dannjjm 3557 27 , , , cord-023095-4dannjjm 3557 28 5 5 CD cord-023095-4dannjjm 3557 29 mg mg NNP cord-023095-4dannjjm 3557 30 / / SYM cord-023095-4dannjjm 3557 31 kg kg NNP cord-023095-4dannjjm 3557 32 , , , cord-023095-4dannjjm 3557 33 IM im UH cord-023095-4dannjjm 3557 34 , , , cord-023095-4dannjjm 3557 35 Day Day NNP cord-023095-4dannjjm 3557 36 0 0 NFP cord-023095-4dannjjm 3557 37 and and CC cord-023095-4dannjjm 3557 38 Day Day NNP cord-023095-4dannjjm 3557 39 21 21 CD cord-023095-4dannjjm 3557 40 ) ) -RRB- cord-023095-4dannjjm 3557 41 , , , cord-023095-4dannjjm 3557 42 CsA CsA NNP cord-023095-4dannjjm 3557 43 ( ( -LRB- cord-023095-4dannjjm 3557 44 8 8 CD cord-023095-4dannjjm 3557 45 cats cat NNS cord-023095-4dannjjm 3557 46 , , , cord-023095-4dannjjm 3557 47 7.0 7.0 CD cord-023095-4dannjjm 3557 48 mg mg NNP cord-023095-4dannjjm 3557 49 / / SYM cord-023095-4dannjjm 3557 50 kg kg NNP cord-023095-4dannjjm 3557 51 , , , cord-023095-4dannjjm 3557 52 PO PO NNP cord-023095-4dannjjm 3557 53 , , , cord-023095-4dannjjm 3557 54 daily daily RB cord-023095-4dannjjm 3557 55 for for IN cord-023095-4dannjjm 3557 56 42 42 CD cord-023095-4dannjjm 3557 57 days day NNS cord-023095-4dannjjm 3557 58 ) ) -RRB- cord-023095-4dannjjm 3557 59 , , , cord-023095-4dannjjm 3557 60 or or CC cord-023095-4dannjjm 3557 61 a a DT cord-023095-4dannjjm 3557 62 placebo placebo NN cord-023095-4dannjjm 3557 63 ( ( -LRB- cord-023095-4dannjjm 3557 64 7 7 CD cord-023095-4dannjjm 3557 65 cats cat NNS cord-023095-4dannjjm 3557 66 , , , cord-023095-4dannjjm 3557 67 corn corn NN cord-023095-4dannjjm 3557 68 syrup syrup NN cord-023095-4dannjjm 3557 69 ; ; : cord-023095-4dannjjm 3557 70 0.075 0.075 CD cord-023095-4dannjjm 3557 71 mL ml NN cord-023095-4dannjjm 3557 72 / / SYM cord-023095-4dannjjm 3557 73 kg kg NNS cord-023095-4dannjjm 3557 74 , , , cord-023095-4dannjjm 3557 75 PO PO NNP cord-023095-4dannjjm 3557 76 , , , cord-023095-4dannjjm 3557 77 daily daily RB cord-023095-4dannjjm 3557 78 for for IN cord-023095-4dannjjm 3557 79 42 42 CD cord-023095-4dannjjm 3557 80 days day NNS cord-023095-4dannjjm 3557 81 ) ) -RRB- cord-023095-4dannjjm 3557 82 . . . cord-023095-4dannjjm 3558 1 Each each DT cord-023095-4dannjjm 3558 2 cat cat NN cord-023095-4dannjjm 3558 3 was be VBD cord-023095-4dannjjm 3558 4 assigned assign VBN cord-023095-4dannjjm 3558 5 a a DT cord-023095-4dannjjm 3558 6 daily daily JJ cord-023095-4dannjjm 3558 7 individual individual JJ cord-023095-4dannjjm 3558 8 clinical clinical JJ cord-023095-4dannjjm 3558 9 score score NN cord-023095-4dannjjm 3558 10 by by IN cord-023095-4dannjjm 3558 11 a a DT cord-023095-4dannjjm 3558 12 trained train VBN cord-023095-4dannjjm 3558 13 , , , cord-023095-4dannjjm 3558 14 masked masked JJ cord-023095-4dannjjm 3558 15 observer observer NN cord-023095-4dannjjm 3558 16 using use VBG cord-023095-4dannjjm 3558 17 a a DT cord-023095-4dannjjm 3558 18 standardized standardized JJ cord-023095-4dannjjm 3558 19 score score NN cord-023095-4dannjjm 3558 20 sheet sheet NN cord-023095-4dannjjm 3558 21 during during IN cord-023095-4dannjjm 3558 22 the the DT cord-023095-4dannjjm 3558 23 initial initial JJ cord-023095-4dannjjm 3558 24 pre pre JJ cord-023095-4dannjjm 3558 25 - - JJ cord-023095-4dannjjm 3558 26 treatment treatment JJ cord-023095-4dannjjm 3558 27 time time NN cord-023095-4dannjjm 3558 28 period period NN cord-023095-4dannjjm 3558 29 ( ( -LRB- cord-023095-4dannjjm 3558 30 Day day NN cord-023095-4dannjjm 3558 31 -14 -14 NN cord-023095-4dannjjm 3558 32 to to IN cord-023095-4dannjjm 3558 33 Day day NN cord-023095-4dannjjm 3558 34 0 0 CD cord-023095-4dannjjm 3558 35 ) ) -RRB- cord-023095-4dannjjm 3558 36 and and CC cord-023095-4dannjjm 3558 37 throughout throughout IN cord-023095-4dannjjm 3558 38 the the DT cord-023095-4dannjjm 3558 39 42 42 CD cord-023095-4dannjjm 3558 40 day day NN cord-023095-4dannjjm 3558 41 treatment treatment NN cord-023095-4dannjjm 3558 42 period period NN cord-023095-4dannjjm 3558 43 . . . cord-023095-4dannjjm 3559 1 Each each DT cord-023095-4dannjjm 3559 2 individual individual JJ cord-023095-4dannjjm 3559 3 clinical clinical JJ cord-023095-4dannjjm 3559 4 score score NN cord-023095-4dannjjm 3559 5 ( ( -LRB- cord-023095-4dannjjm 3559 6 conjunctivitis conjunctivitis NN cord-023095-4dannjjm 3559 7 , , , cord-023095-4dannjjm 3559 8 blepharospasm blepharospasm NN cord-023095-4dannjjm 3559 9 , , , cord-023095-4dannjjm 3559 10 ocular ocular JJ cord-023095-4dannjjm 3559 11 discharge discharge NN cord-023095-4dannjjm 3559 12 , , , cord-023095-4dannjjm 3559 13 sneezing sneezing NN cord-023095-4dannjjm 3559 14 , , , cord-023095-4dannjjm 3559 15 nasal nasal NN cord-023095-4dannjjm 3559 16 discharge discharge NN cord-023095-4dannjjm 3559 17 , , , cord-023095-4dannjjm 3559 18 nasal nasal NN cord-023095-4dannjjm 3559 19 congestion congestion NN cord-023095-4dannjjm 3559 20 , , , cord-023095-4dannjjm 3559 21 and and CC cord-023095-4dannjjm 3559 22 body body NN cord-023095-4dannjjm 3559 23 temperature temperature NN cord-023095-4dannjjm 3559 24 scores score NNS cord-023095-4dannjjm 3559 25 ) ) -RRB- cord-023095-4dannjjm 3559 26 , , , cord-023095-4dannjjm 3559 27 the the DT cord-023095-4dannjjm 3559 28 total total JJ cord-023095-4dannjjm 3559 29 clinical clinical JJ cord-023095-4dannjjm 3559 30 score score NN cord-023095-4dannjjm 3559 31 ( ( -LRB- cord-023095-4dannjjm 3559 32 sum sum NN cord-023095-4dannjjm 3559 33 of of IN cord-023095-4dannjjm 3559 34 all all DT cord-023095-4dannjjm 3559 35 parameters parameter NNS cord-023095-4dannjjm 3559 36 ) ) -RRB- cord-023095-4dannjjm 3559 37 , , , cord-023095-4dannjjm 3559 38 the the DT cord-023095-4dannjjm 3559 39 total total JJ cord-023095-4dannjjm 3559 40 ocular ocular JJ cord-023095-4dannjjm 3559 41 score score NN cord-023095-4dannjjm 3559 42 ( ( -LRB- cord-023095-4dannjjm 3559 43 sum sum NN cord-023095-4dannjjm 3559 44 of of IN cord-023095-4dannjjm 3559 45 conjunctivitis conjunctivitis NN cord-023095-4dannjjm 3559 46 , , , cord-023095-4dannjjm 3559 47 blepharospasm blepharospasm NN cord-023095-4dannjjm 3559 48 , , , cord-023095-4dannjjm 3559 49 ocular ocular JJ cord-023095-4dannjjm 3559 50 discharge discharge NN cord-023095-4dannjjm 3559 51 ) ) -RRB- cord-023095-4dannjjm 3559 52 , , , cord-023095-4dannjjm 3559 53 and and CC cord-023095-4dannjjm 3559 54 total total JJ cord-023095-4dannjjm 3559 55 respiratory respiratory JJ cord-023095-4dannjjm 3559 56 score score NN cord-023095-4dannjjm 3559 57 ( ( -LRB- cord-023095-4dannjjm 3559 58 sum sum NN cord-023095-4dannjjm 3559 59 of of IN cord-023095-4dannjjm 3559 60 ocular ocular JJ cord-023095-4dannjjm 3559 61 discharge discharge NN cord-023095-4dannjjm 3559 62 , , , cord-023095-4dannjjm 3559 63 sneezing sneezing NN cord-023095-4dannjjm 3559 64 , , , cord-023095-4dannjjm 3559 65 nasal nasal NN cord-023095-4dannjjm 3559 66 discharge discharge NN cord-023095-4dannjjm 3559 67 , , , cord-023095-4dannjjm 3559 68 nasal nasal NN cord-023095-4dannjjm 3559 69 congestion congestion NN cord-023095-4dannjjm 3559 70 ) ) -RRB- cord-023095-4dannjjm 3559 71 were be VBD cord-023095-4dannjjm 3559 72 analyzed analyze VBN cord-023095-4dannjjm 3559 73 using use VBG cord-023095-4dannjjm 3559 74 SAS SAS NNP cord-023095-4dannjjm 3559 75 PROC PROC NNP cord-023095-4dannjjm 3559 76 GLIMMIX GLIMMIX NNP cord-023095-4dannjjm 3559 77 with with IN cord-023095-4dannjjm 3559 78 ' ' `` cord-023095-4dannjjm 3559 79 Treatment Treatment NNP cord-023095-4dannjjm 3559 80 ' ' '' cord-023095-4dannjjm 3559 81 , , , cord-023095-4dannjjm 3559 82 ' ' '' cord-023095-4dannjjm 3559 83 Time Time NNP cord-023095-4dannjjm 3559 84 ' ' '' cord-023095-4dannjjm 3559 85 , , , cord-023095-4dannjjm 3559 86 and and CC cord-023095-4dannjjm 3559 87 the the DT cord-023095-4dannjjm 3559 88 two two CD cord-023095-4dannjjm 3559 89 - - HYPH cord-023095-4dannjjm 3559 90 way way NN cord-023095-4dannjjm 3559 91 interaction interaction NN cord-023095-4dannjjm 3559 92 ' ' '' cord-023095-4dannjjm 3559 93 Treatment treatment NN cord-023095-4dannjjm 3559 94 by by IN cord-023095-4dannjjm 3559 95 Time Time NNP cord-023095-4dannjjm 3559 96 ' ' '' cord-023095-4dannjjm 3559 97 all all DT cord-023095-4dannjjm 3559 98 as as IN cord-023095-4dannjjm 3559 99 fixed fix VBN cord-023095-4dannjjm 3559 100 effects effect NNS cord-023095-4dannjjm 3559 101 . . . cord-023095-4dannjjm 3560 1 Statistical statistical JJ cord-023095-4dannjjm 3560 2 significance significance NN cord-023095-4dannjjm 3560 3 was be VBD cord-023095-4dannjjm 3560 4 defined define VBN cord-023095-4dannjjm 3560 5 as as IN cord-023095-4dannjjm 3560 6 p p NN cord-023095-4dannjjm 3560 7 o o NN cord-023095-4dannjjm 3560 8 0.05 0.05 CD cord-023095-4dannjjm 3560 9 . . . cord-023095-4dannjjm 3561 1 On on IN cord-023095-4dannjjm 3561 2 Day Day NNP cord-023095-4dannjjm 3561 3 42 42 CD cord-023095-4dannjjm 3561 4 of of IN cord-023095-4dannjjm 3561 5 the the DT cord-023095-4dannjjm 3561 6 study study NN cord-023095-4dannjjm 3561 7 , , , cord-023095-4dannjjm 3561 8 all all DT cord-023095-4dannjjm 3561 9 of of IN cord-023095-4dannjjm 3561 10 the the DT cord-023095-4dannjjm 3561 11 CsA CsA NNP cord-023095-4dannjjm 3561 12 treated treat VBN cord-023095-4dannjjm 3561 13 cats cat NNS cord-023095-4dannjjm 3561 14 had have VBD cord-023095-4dannjjm 3561 15 detectable detectable JJ cord-023095-4dannjjm 3561 16 concentrations concentration NNS cord-023095-4dannjjm 3561 17 of of IN cord-023095-4dannjjm 3561 18 CsA csa NN cord-023095-4dannjjm 3561 19 in in IN cord-023095-4dannjjm 3561 20 serum serum NN cord-023095-4dannjjm 3562 1 ( ( -LRB- cord-023095-4dannjjm 3562 2 Mean mean JJ cord-023095-4dannjjm 3562 3 5 5 CD cord-023095-4dannjjm 3562 4 406.1 406.1 CD cord-023095-4dannjjm 3562 5 ng ng NN cord-023095-4dannjjm 3562 6 / / SYM cord-023095-4dannjjm 3562 7 ml ml NN cord-023095-4dannjjm 3562 8 ; ; : cord-023095-4dannjjm 3562 9 standard standard JJ cord-023095-4dannjjm 3562 10 deviation deviation NN cord-023095-4dannjjm 3562 11 5 5 CD cord-023095-4dannjjm 3562 12 291.8 291.8 CD cord-023095-4dannjjm 3562 13 ng ng NN cord-023095-4dannjjm 3562 14 / / SYM cord-023095-4dannjjm 3562 15 ml ml NN cord-023095-4dannjjm 3562 16 ; ; : cord-023095-4dannjjm 3563 1 Median median JJ cord-023095-4dannjjm 3563 2 5 5 CD cord-023095-4dannjjm 3563 3 388.5 388.5 CD cord-023095-4dannjjm 3563 4 ng ng NN cord-023095-4dannjjm 3563 5 / / SYM cord-023095-4dannjjm 3563 6 ml ml NN cord-023095-4dannjjm 3563 7 ) ) -RRB- cord-023095-4dannjjm 3563 8 . . . cord-023095-4dannjjm 3564 1 When when WRB cord-023095-4dannjjm 3564 2 group group NN cord-023095-4dannjjm 3564 3 mean mean JJ cord-023095-4dannjjm 3564 4 values value NNS cord-023095-4dannjjm 3564 5 for for IN cord-023095-4dannjjm 3564 6 clinical clinical JJ cord-023095-4dannjjm 3564 7 signs sign NNS cord-023095-4dannjjm 3564 8 were be VBD cord-023095-4dannjjm 3564 9 compared compare VBN cord-023095-4dannjjm 3564 10 over over IN cord-023095-4dannjjm 3564 11 time time NN cord-023095-4dannjjm 3564 12 as as IN cord-023095-4dannjjm 3564 13 described describe VBN cord-023095-4dannjjm 3564 14 , , , cord-023095-4dannjjm 3564 15 significant significant JJ cord-023095-4dannjjm 3564 16 differences difference NNS cord-023095-4dannjjm 3564 17 in in IN cord-023095-4dannjjm 3564 18 individual individual JJ cord-023095-4dannjjm 3564 19 clinical clinical JJ cord-023095-4dannjjm 3564 20 score score NN cord-023095-4dannjjm 3564 21 measurements measurement NNS cord-023095-4dannjjm 3564 22 , , , cord-023095-4dannjjm 3564 23 in in IN cord-023095-4dannjjm 3564 24 total total JJ cord-023095-4dannjjm 3564 25 score score NN cord-023095-4dannjjm 3564 26 , , , cord-023095-4dannjjm 3564 27 total total JJ cord-023095-4dannjjm 3564 28 ocular ocular JJ cord-023095-4dannjjm 3564 29 score score NN cord-023095-4dannjjm 3564 30 , , , cord-023095-4dannjjm 3564 31 or or CC cord-023095-4dannjjm 3564 32 total total JJ cord-023095-4dannjjm 3564 33 respiratory respiratory JJ cord-023095-4dannjjm 3564 34 score score NN cord-023095-4dannjjm 3564 35 were be VBD cord-023095-4dannjjm 3564 36 not not RB cord-023095-4dannjjm 3564 37 detected detect VBN cord-023095-4dannjjm 3564 38 over over IN cord-023095-4dannjjm 3564 39 time time NN cord-023095-4dannjjm 3564 40 among among IN cord-023095-4dannjjm 3564 41 any any DT cord-023095-4dannjjm 3564 42 of of IN cord-023095-4dannjjm 3564 43 the the DT cord-023095-4dannjjm 3564 44 treatment treatment NN cord-023095-4dannjjm 3564 45 groups group NNS cord-023095-4dannjjm 3564 46 . . . cord-023095-4dannjjm 3565 1 While while IN cord-023095-4dannjjm 3565 2 clinical clinical JJ cord-023095-4dannjjm 3565 3 signs sign NNS cord-023095-4dannjjm 3565 4 of of IN cord-023095-4dannjjm 3565 5 activated activate VBN cord-023095-4dannjjm 3565 6 FHV-1 FHV-1 NNP cord-023095-4dannjjm 3565 7 occurred occur VBD cord-023095-4dannjjm 3565 8 in in IN cord-023095-4dannjjm 3565 9 some some DT cord-023095-4dannjjm 3565 10 cats cat NNS cord-023095-4dannjjm 3565 11 administered administer VBD cord-023095-4dannjjm 3565 12 methylprednisolone methylprednisolone NNP cord-023095-4dannjjm 3565 13 or or CC cord-023095-4dannjjm 3565 14 CsA CsA NNP cord-023095-4dannjjm 3565 15 , , , cord-023095-4dannjjm 3565 16 disease disease NN cord-023095-4dannjjm 3565 17 was be VBD cord-023095-4dannjjm 3565 18 mild mild JJ cord-023095-4dannjjm 3565 19 and and CC cord-023095-4dannjjm 3565 20 self self NN cord-023095-4dannjjm 3565 21 - - HYPH cord-023095-4dannjjm 3565 22 limited limit VBN cord-023095-4dannjjm 3565 23 in in IN cord-023095-4dannjjm 3565 24 most most JJS cord-023095-4dannjjm 3565 25 cats cat NNS cord-023095-4dannjjm 3565 26 and and CC cord-023095-4dannjjm 3565 27 there there EX cord-023095-4dannjjm 3565 28 were be VBD cord-023095-4dannjjm 3565 29 no no DT cord-023095-4dannjjm 3565 30 significant significant JJ cord-023095-4dannjjm 3565 31 CsA csa NN cord-023095-4dannjjm 3565 32 sideeffects sideeffect NNS cord-023095-4dannjjm 3565 33 . . . cord-023095-4dannjjm 3566 1 These these DT cord-023095-4dannjjm 3566 2 results result NNS cord-023095-4dannjjm 3566 3 suggest suggest VBP cord-023095-4dannjjm 3566 4 that that IN cord-023095-4dannjjm 3566 5 the the DT cord-023095-4dannjjm 3566 6 CsA CsA NNP cord-023095-4dannjjm 3566 7 protocol protocol NN cord-023095-4dannjjm 3566 8 described describe VBN cord-023095-4dannjjm 3566 9 here here RB cord-023095-4dannjjm 3566 10 is be VBZ cord-023095-4dannjjm 3566 11 unlikely unlikely JJ cord-023095-4dannjjm 3566 12 to to TO cord-023095-4dannjjm 3566 13 reactivate reactivate VB cord-023095-4dannjjm 3566 14 latent latent JJ cord-023095-4dannjjm 3566 15 FHV-1 FHV-1 NNP cord-023095-4dannjjm 3566 16 infection infection NN cord-023095-4dannjjm 3566 17 and and CC cord-023095-4dannjjm 3566 18 cause cause VB cord-023095-4dannjjm 3566 19 significant significant JJ cord-023095-4dannjjm 3566 20 clinical clinical JJ cord-023095-4dannjjm 3566 21 illness illness NN cord-023095-4dannjjm 3566 22 . . . cord-023095-4dannjjm 3567 1 The the DT cord-023095-4dannjjm 3567 2 purpose purpose NN cord-023095-4dannjjm 3567 3 of of IN cord-023095-4dannjjm 3567 4 this this DT cord-023095-4dannjjm 3567 5 study study NN cord-023095-4dannjjm 3567 6 was be VBD cord-023095-4dannjjm 3567 7 to to TO cord-023095-4dannjjm 3567 8 determine determine VB cord-023095-4dannjjm 3567 9 the the DT cord-023095-4dannjjm 3567 10 prevalence prevalence NN cord-023095-4dannjjm 3567 11 and and CC cord-023095-4dannjjm 3567 12 risk risk NN cord-023095-4dannjjm 3567 13 factors factor NNS cord-023095-4dannjjm 3567 14 for for IN cord-023095-4dannjjm 3567 15 enteropathogens enteropathogen NNS cord-023095-4dannjjm 3567 16 in in IN cord-023095-4dannjjm 3567 17 four four CD cord-023095-4dannjjm 3567 18 different different JJ cord-023095-4dannjjm 3567 19 models model NNS cord-023095-4dannjjm 3567 20 for for IN cord-023095-4dannjjm 3567 21 managing manage VBG cord-023095-4dannjjm 3567 22 unowned unowned JJ cord-023095-4dannjjm 3567 23 cats cat NNS cord-023095-4dannjjm 3567 24 : : : cord-023095-4dannjjm 3567 25 short short JJ cord-023095-4dannjjm 3567 26 - - HYPH cord-023095-4dannjjm 3567 27 term term NN cord-023095-4dannjjm 3567 28 shelter shelter NN cord-023095-4dannjjm 3567 29 , , , cord-023095-4dannjjm 3567 30 long long JJ cord-023095-4dannjjm 3567 31 - - HYPH cord-023095-4dannjjm 3567 32 term term NN cord-023095-4dannjjm 3567 33 sanctuary sanctuary NN cord-023095-4dannjjm 3567 34 , , , cord-023095-4dannjjm 3567 35 home home NN cord-023095-4dannjjm 3567 36 - - HYPH cord-023095-4dannjjm 3567 37 based base VBN cord-023095-4dannjjm 3567 38 foster foster JJ cord-023095-4dannjjm 3567 39 care care NN cord-023095-4dannjjm 3567 40 , , , cord-023095-4dannjjm 3567 41 and and CC cord-023095-4dannjjm 3567 42 trap trap NN cord-023095-4dannjjm 3567 43 - - HYPH cord-023095-4dannjjm 3567 44 neuter neuter NN cord-023095-4dannjjm 3567 45 - - JJ cord-023095-4dannjjm 3567 46 return return NN cord-023095-4dannjjm 3567 47 ( ( -LRB- cord-023095-4dannjjm 3567 48 TNR TNR NNP cord-023095-4dannjjm 3567 49 ) ) -RRB- cord-023095-4dannjjm 3567 50 programs program NNS cord-023095-4dannjjm 3567 51 . . . cord-023095-4dannjjm 3568 1 Fecal fecal JJ cord-023095-4dannjjm 3568 2 samples sample NNS cord-023095-4dannjjm 3568 3 were be VBD cord-023095-4dannjjm 3568 4 collected collect VBN cord-023095-4dannjjm 3568 5 from from IN cord-023095-4dannjjm 3568 6 482 482 CD cord-023095-4dannjjm 3568 7 cats cat NNS cord-023095-4dannjjm 3568 8 , , , cord-023095-4dannjjm 3568 9 half half NN cord-023095-4dannjjm 3568 10 with with IN cord-023095-4dannjjm 3568 11 diarrhea diarrhea NN cord-023095-4dannjjm 3568 12 ( ( -LRB- cord-023095-4dannjjm 3568 13 D D NNP cord-023095-4dannjjm 3568 14 ) ) -RRB- cord-023095-4dannjjm 3568 15 and and CC cord-023095-4dannjjm 3568 16 half half NN cord-023095-4dannjjm 3568 17 with with IN cord-023095-4dannjjm 3568 18 normal normal JJ cord-023095-4dannjjm 3568 19 feces fece NNS cord-023095-4dannjjm 3568 20 ( ( -LRB- cord-023095-4dannjjm 3568 21 N N NNP cord-023095-4dannjjm 3568 22 ) ) -RRB- cord-023095-4dannjjm 3568 23 , , , cord-023095-4dannjjm 3568 24 and and CC cord-023095-4dannjjm 3568 25 tested test VBN cord-023095-4dannjjm 3568 26 for for IN cord-023095-4dannjjm 3568 27 a a DT cord-023095-4dannjjm 3568 28 panel panel NN cord-023095-4dannjjm 3568 29 of of IN cord-023095-4dannjjm 3568 30 feline feline JJ cord-023095-4dannjjm 3568 31 and and CC cord-023095-4dannjjm 3568 32 zoonotic zoonotic JJ cord-023095-4dannjjm 3568 33 enteropathogens enteropathogen NNS cord-023095-4dannjjm 3568 34 by by IN cord-023095-4dannjjm 3568 35 polymerase polymerase NN cord-023095-4dannjjm 3568 36 chain chain NN cord-023095-4dannjjm 3568 37 reaction reaction NN cord-023095-4dannjjm 3568 38 , , , cord-023095-4dannjjm 3568 39 antigen antigen NN cord-023095-4dannjjm 3568 40 , , , cord-023095-4dannjjm 3568 41 and and CC cord-023095-4dannjjm 3568 42 fecal fecal JJ cord-023095-4dannjjm 3568 43 flotation flotation NN cord-023095-4dannjjm 3568 44 . . . cord-023095-4dannjjm 3569 1 Risk risk NN cord-023095-4dannjjm 3569 2 factors factor NNS cord-023095-4dannjjm 3569 3 for for IN cord-023095-4dannjjm 3569 4 infection infection NN cord-023095-4dannjjm 3569 5 evaluated evaluate VBN cord-023095-4dannjjm 3569 6 include include VBP cord-023095-4dannjjm 3569 7 management management NN cord-023095-4dannjjm 3569 8 practices practice NNS cord-023095-4dannjjm 3569 9 , , , cord-023095-4dannjjm 3569 10 fecal fecal JJ cord-023095-4dannjjm 3569 11 consistency consistency NN cord-023095-4dannjjm 3569 12 , , , cord-023095-4dannjjm 3569 13 and and CC cord-023095-4dannjjm 3569 14 signalment signalment JJ cord-023095-4dannjjm 3569 15 . . . cord-023095-4dannjjm 3570 1 A a DT cord-023095-4dannjjm 3570 2 majority majority NN cord-023095-4dannjjm 3570 3 of of IN cord-023095-4dannjjm 3570 4 cats cat NNS cord-023095-4dannjjm 3570 5 had have VBD cord-023095-4dannjjm 3570 6 at at RB cord-023095-4dannjjm 3570 7 least least RBS cord-023095-4dannjjm 3570 8 one one CD cord-023095-4dannjjm 3570 9 enteropathogen enteropathogen NN cord-023095-4dannjjm 3570 10 of of IN cord-023095-4dannjjm 3570 11 feline feline JJ cord-023095-4dannjjm 3570 12 or or CC cord-023095-4dannjjm 3570 13 zoonotic zoonotic JJ cord-023095-4dannjjm 3570 14 importance importance NN cord-023095-4dannjjm 3570 15 , , , cord-023095-4dannjjm 3570 16 regardless regardless RB cord-023095-4dannjjm 3570 17 of of IN cord-023095-4dannjjm 3570 18 management management NN cord-023095-4dannjjm 3570 19 model model NN cord-023095-4dannjjm 3570 20 or or CC cord-023095-4dannjjm 3570 21 preventive preventive JJ cord-023095-4dannjjm 3570 22 healthcare healthcare NN cord-023095-4dannjjm 3570 23 protocol protocol NN cord-023095-4dannjjm 3570 24 . . . cord-023095-4dannjjm 3571 1 For for IN cord-023095-4dannjjm 3571 2 most most JJS cord-023095-4dannjjm 3571 3 enteropathogens enteropathogen NNS cord-023095-4dannjjm 3571 4 , , , cord-023095-4dannjjm 3571 5 the the DT cord-023095-4dannjjm 3571 6 presence presence NN cord-023095-4dannjjm 3571 7 or or CC cord-023095-4dannjjm 3571 8 absence absence NN cord-023095-4dannjjm 3571 9 of of IN cord-023095-4dannjjm 3571 10 diarrhea diarrhea NN cord-023095-4dannjjm 3571 11 did do VBD cord-023095-4dannjjm 3571 12 not not RB cord-023095-4dannjjm 3571 13 correlate correlate VB cord-023095-4dannjjm 3571 14 with with IN cord-023095-4dannjjm 3571 15 infection infection NN cord-023095-4dannjjm 3571 16 , , , cord-023095-4dannjjm 3571 17 the the DT cord-023095-4dannjjm 3571 18 exceptions exception NNS cord-023095-4dannjjm 3571 19 being be VBG cord-023095-4dannjjm 3571 20 T. t. NN cord-023095-4dannjjm 3571 21 foetus foetus NN cord-023095-4dannjjm 3571 22 in in IN cord-023095-4dannjjm 3571 23 sanctuary sanctuary NN cord-023095-4dannjjm 3571 24 cats cat NNS cord-023095-4dannjjm 3571 25 and and CC cord-023095-4dannjjm 3571 26 FCoV FCoV NNP cord-023095-4dannjjm 3571 27 in in IN cord-023095-4dannjjm 3571 28 foster foster JJ cord-023095-4dannjjm 3571 29 cats cat NNS cord-023095-4dannjjm 3571 30 . . . cord-023095-4dannjjm 3572 1 Prevalence prevalence NN cord-023095-4dannjjm 3572 2 of of IN cord-023095-4dannjjm 3572 3 specific specific JJ cord-023095-4dannjjm 3572 4 enteropathogens enteropathogen NNS cord-023095-4dannjjm 3572 5 varied varied JJ cord-023095-4dannjjm 3572 6 between between IN cord-023095-4dannjjm 3572 7 management management NN cord-023095-4dannjjm 3572 8 models model NNS cord-023095-4dannjjm 3572 9 , , , cord-023095-4dannjjm 3572 10 reflecting reflect VBG cord-023095-4dannjjm 3572 11 differences difference NNS cord-023095-4dannjjm 3572 12 in in IN cord-023095-4dannjjm 3572 13 preventive preventive JJ cord-023095-4dannjjm 3572 14 healthcare healthcare NN cord-023095-4dannjjm 3572 15 and and CC cord-023095-4dannjjm 3572 16 housing housing NN cord-023095-4dannjjm 3572 17 conditions condition NNS cord-023095-4dannjjm 3572 18 . . . cord-023095-4dannjjm 3573 1 Management management NN cord-023095-4dannjjm 3573 2 protocols protocol NNS cord-023095-4dannjjm 3573 3 for for IN cord-023095-4dannjjm 3573 4 unowned unowned JJ cord-023095-4dannjjm 3573 5 cats cat NNS cord-023095-4dannjjm 3573 6 were be VBD cord-023095-4dannjjm 3573 7 inadequate inadequate JJ cord-023095-4dannjjm 3573 8 for for IN cord-023095-4dannjjm 3573 9 elimination elimination NN cord-023095-4dannjjm 3573 10 of of IN cord-023095-4dannjjm 3573 11 infections infection NNS cord-023095-4dannjjm 3573 12 present present JJ cord-023095-4dannjjm 3573 13 at at IN cord-023095-4dannjjm 3573 14 the the DT cord-023095-4dannjjm 3573 15 time time NN cord-023095-4dannjjm 3573 16 of of IN cord-023095-4dannjjm 3573 17 intake intake NN cord-023095-4dannjjm 3573 18 and and CC cord-023095-4dannjjm 3573 19 for for IN cord-023095-4dannjjm 3573 20 prevention prevention NN cord-023095-4dannjjm 3573 21 of of IN cord-023095-4dannjjm 3573 22 transmission transmission NN cord-023095-4dannjjm 3573 23 of of IN cord-023095-4dannjjm 3573 24 enteropathogens enteropathogen NNS cord-023095-4dannjjm 3573 25 among among IN cord-023095-4dannjjm 3573 26 shelter shelter NN cord-023095-4dannjjm 3573 27 cats cat NNS cord-023095-4dannjjm 3573 28 . . . cord-023095-4dannjjm 3574 1 Improved improve VBN cord-023095-4dannjjm 3574 2 compliance compliance NN cord-023095-4dannjjm 3574 3 with with IN cord-023095-4dannjjm 3574 4 effective effective JJ cord-023095-4dannjjm 3574 5 vaccination vaccination NN cord-023095-4dannjjm 3574 6 , , , cord-023095-4dannjjm 3574 7 deworming deworming NN cord-023095-4dannjjm 3574 8 , , , cord-023095-4dannjjm 3574 9 sanitation sanitation NN cord-023095-4dannjjm 3574 10 , , , cord-023095-4dannjjm 3574 11 and and CC cord-023095-4dannjjm 3574 12 housing housing NN cord-023095-4dannjjm 3574 13 protocols protocol NNS cord-023095-4dannjjm 3574 14 is be VBZ cord-023095-4dannjjm 3574 15 needed need VBN cord-023095-4dannjjm 3574 16 to to TO cord-023095-4dannjjm 3574 17 reduce reduce VB cord-023095-4dannjjm 3574 18 zoonotic zoonotic JJ cord-023095-4dannjjm 3574 19 and and CC cord-023095-4dannjjm 3574 20 feline feline JJ cord-023095-4dannjjm 3574 21 health health NN cord-023095-4dannjjm 3574 22 risks risk NNS cord-023095-4dannjjm 3574 23 . . . cord-023095-4dannjjm 3575 1 Several several JJ cord-023095-4dannjjm 3575 2 allergic allergic JJ cord-023095-4dannjjm 3575 3 diseases disease NNS cord-023095-4dannjjm 3575 4 of of IN cord-023095-4dannjjm 3575 5 cats cat NNS cord-023095-4dannjjm 3575 6 , , , cord-023095-4dannjjm 3575 7 including include VBG cord-023095-4dannjjm 3575 8 atopy atopy NN cord-023095-4dannjjm 3575 9 and and CC cord-023095-4dannjjm 3575 10 gingivostomatitis gingivostomatitis NN cord-023095-4dannjjm 3575 11 , , , cord-023095-4dannjjm 3575 12 can can MD cord-023095-4dannjjm 3575 13 be be VB cord-023095-4dannjjm 3575 14 resistant resistant JJ cord-023095-4dannjjm 3575 15 to to IN cord-023095-4dannjjm 3575 16 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 3575 17 but but CC cord-023095-4dannjjm 3575 18 responsive responsive JJ cord-023095-4dannjjm 3575 19 to to IN cord-023095-4dannjjm 3575 20 cyclosporine cyclosporine NN cord-023095-4dannjjm 3575 21 . . . cord-023095-4dannjjm 3576 1 Toxoplasma toxoplasma NN cord-023095-4dannjjm 3576 2 gondii gondii NN cord-023095-4dannjjm 3576 3 infection infection NN cord-023095-4dannjjm 3576 4 occurs occur VBZ cord-023095-4dannjjm 3576 5 in in IN cord-023095-4dannjjm 3576 6 approximately approximately RB cord-023095-4dannjjm 3576 7 30 30 CD cord-023095-4dannjjm 3576 8 % % NN cord-023095-4dannjjm 3576 9 of of IN cord-023095-4dannjjm 3576 10 cats cat NNS cord-023095-4dannjjm 3576 11 and and CC cord-023095-4dannjjm 3576 12 the the DT cord-023095-4dannjjm 3576 13 effect effect NN cord-023095-4dannjjm 3576 14 cyclosporine cyclosporine NN cord-023095-4dannjjm 3576 15 therapy therapy NN cord-023095-4dannjjm 3576 16 has have VBZ cord-023095-4dannjjm 3576 17 on on IN cord-023095-4dannjjm 3576 18 the the DT cord-023095-4dannjjm 3576 19 T. T. NNP cord-023095-4dannjjm 3576 20 gondii gondii NNP cord-023095-4dannjjm 3576 21 oocyst oocyst VBN cord-023095-4dannjjm 3576 22 shedding shed VBG cord-023095-4dannjjm 3576 23 period period NN cord-023095-4dannjjm 3576 24 is be VBZ cord-023095-4dannjjm 3576 25 unknown unknown JJ cord-023095-4dannjjm 3576 26 . . . cord-023095-4dannjjm 3577 1 The the DT cord-023095-4dannjjm 3577 2 objective objective NN cord-023095-4dannjjm 3577 3 of of IN cord-023095-4dannjjm 3577 4 this this DT cord-023095-4dannjjm 3577 5 study study NN cord-023095-4dannjjm 3577 6 was be VBD cord-023095-4dannjjm 3577 7 to to TO cord-023095-4dannjjm 3577 8 determine determine VB cord-023095-4dannjjm 3577 9 whether whether IN cord-023095-4dannjjm 3577 10 administration administration NN cord-023095-4dannjjm 3577 11 of of IN cord-023095-4dannjjm 3577 12 cyclosporine cyclosporine NN cord-023095-4dannjjm 3577 13 before before RB cord-023095-4dannjjm 3577 14 or or CC cord-023095-4dannjjm 3577 15 after after IN cord-023095-4dannjjm 3577 16 T. T. NNP cord-023095-4dannjjm 3577 17 gondii gondii NNP cord-023095-4dannjjm 3577 18 infection infection NN cord-023095-4dannjjm 3577 19 influences influence VBZ cord-023095-4dannjjm 3577 20 the the DT cord-023095-4dannjjm 3577 21 oocyst oocyst JJ cord-023095-4dannjjm 3577 22 shedding shed VBG cord-023095-4dannjjm 3577 23 period period NN cord-023095-4dannjjm 3577 24 . . . cord-023095-4dannjjm 3578 1 The the DT cord-023095-4dannjjm 3578 2 young young JJ cord-023095-4dannjjm 3578 3 adult adult NN cord-023095-4dannjjm 3578 4 cats cat NNS cord-023095-4dannjjm 3578 5 were be VBD cord-023095-4dannjjm 3578 6 T. t. NN cord-023095-4dannjjm 3578 7 gondii gondii NNP cord-023095-4dannjjm 3578 8 seronegative seronegative JJ cord-023095-4dannjjm 3578 9 when when WRB cord-023095-4dannjjm 3578 10 administered administer VBN cord-023095-4dannjjm 3578 11 1,000 1,000 CD cord-023095-4dannjjm 3578 12 T. t. NN cord-023095-4dannjjm 3578 13 gondii gondii NN cord-023095-4dannjjm 3578 14 tissue tissue NN cord-023095-4dannjjm 3578 15 cysts cyst NNS cord-023095-4dannjjm 3578 16 orally orally RB cord-023095-4dannjjm 3578 17 on on IN cord-023095-4dannjjm 3578 18 day day NN cord-023095-4dannjjm 3578 19 42 42 CD cord-023095-4dannjjm 3578 20 . . . cord-023095-4dannjjm 3579 1 Group group NN cord-023095-4dannjjm 3579 2 1 1 CD cord-023095-4dannjjm 3579 3 cats cat NNS cord-023095-4dannjjm 3579 4 ( ( -LRB- cord-023095-4dannjjm 3579 5 n n NN cord-023095-4dannjjm 3579 6 5 5 CD cord-023095-4dannjjm 3579 7 10 10 CD cord-023095-4dannjjm 3579 8 ) ) -RRB- cord-023095-4dannjjm 3579 9 were be VBD cord-023095-4dannjjm 3579 10 never never RB cord-023095-4dannjjm 3579 11 administered administer VBN cord-023095-4dannjjm 3579 12 cyclosporine cyclosporine NN cord-023095-4dannjjm 3579 13 ; ; : cord-023095-4dannjjm 3579 14 Group group NN cord-023095-4dannjjm 3579 15 2 2 CD cord-023095-4dannjjm 3579 16 cats cat NNS cord-023095-4dannjjm 3579 17 ( ( -LRB- cord-023095-4dannjjm 3579 18 n n NN cord-023095-4dannjjm 3579 19 5 5 CD cord-023095-4dannjjm 3579 20 10 10 CD cord-023095-4dannjjm 3579 21 ) ) -RRB- cord-023095-4dannjjm 3579 22 were be VBD cord-023095-4dannjjm 3579 23 administered administer VBN cord-023095-4dannjjm 3579 24 cyclosporine cyclosporine NN cord-023095-4dannjjm 3579 25 ( ( -LRB- cord-023095-4dannjjm 3579 26 7.5 7.5 CD cord-023095-4dannjjm 3579 27 mg mg NNP cord-023095-4dannjjm 3579 28 / / SYM cord-023095-4dannjjm 3579 29 kg kg NNP cord-023095-4dannjjm 3579 30 , , , cord-023095-4dannjjm 3579 31 PO PO NNP cord-023095-4dannjjm 3579 32 ) ) -RRB- cord-023095-4dannjjm 3580 1 daily daily RB cord-023095-4dannjjm 3580 2 on on IN cord-023095-4dannjjm 3580 3 Days Days NNPS cord-023095-4dannjjm 3580 4 84 84 CD cord-023095-4dannjjm 3580 5 - - SYM cord-023095-4dannjjm 3580 6 126 126 CD cord-023095-4dannjjm 3580 7 ; ; : cord-023095-4dannjjm 3580 8 and and CC cord-023095-4dannjjm 3580 9 Group group NN cord-023095-4dannjjm 3580 10 3 3 CD cord-023095-4dannjjm 3580 11 cats cat NNS cord-023095-4dannjjm 3580 12 ( ( -LRB- cord-023095-4dannjjm 3580 13 n n NN cord-023095-4dannjjm 3580 14 5 5 CD cord-023095-4dannjjm 3580 15 10 10 CD cord-023095-4dannjjm 3580 16 ) ) -RRB- cord-023095-4dannjjm 3580 17 were be VBD cord-023095-4dannjjm 3580 18 administered administer VBN cord-023095-4dannjjm 3580 19 cyclosporine cyclosporine NN cord-023095-4dannjjm 3580 20 ( ( -LRB- cord-023095-4dannjjm 3580 21 7.5 7.5 CD cord-023095-4dannjjm 3580 22 mg mg NNP cord-023095-4dannjjm 3580 23 / / SYM cord-023095-4dannjjm 3580 24 kg kg NNP cord-023095-4dannjjm 3580 25 , , , cord-023095-4dannjjm 3580 26 PO PO NNP cord-023095-4dannjjm 3580 27 ) ) -RRB- cord-023095-4dannjjm 3580 28 daily daily RB cord-023095-4dannjjm 3580 29 from from IN cord-023095-4dannjjm 3580 30 days day NNS cord-023095-4dannjjm 3580 31 0 0 CD cord-023095-4dannjjm 3580 32 - - SYM cord-023095-4dannjjm 3580 33 126 126 CD cord-023095-4dannjjm 3580 34 . . . cord-023095-4dannjjm 3581 1 Available available JJ cord-023095-4dannjjm 3581 2 feces fece NNS cord-023095-4dannjjm 3581 3 from from IN cord-023095-4dannjjm 3581 4 individual individual JJ cord-023095-4dannjjm 3581 5 cages cage NNS cord-023095-4dannjjm 3581 6 were be VBD cord-023095-4dannjjm 3581 7 collected collect VBN cord-023095-4dannjjm 3581 8 daily daily JJ cord-023095-4dannjjm 3581 9 and and CC cord-023095-4dannjjm 3581 10 fecal fecal JJ cord-023095-4dannjjm 3581 11 flotation flotation NN cord-023095-4dannjjm 3581 12 by by IN cord-023095-4dannjjm 3581 13 sugar sugar NN cord-023095-4dannjjm 3581 14 centrifugation centrifugation NN cord-023095-4dannjjm 3581 15 was be VBD cord-023095-4dannjjm 3581 16 performed perform VBN cord-023095-4dannjjm 3581 17 for for IN cord-023095-4dannjjm 3581 18 84 84 CD cord-023095-4dannjjm 3581 19 days day NNS cord-023095-4dannjjm 3581 20 after after IN cord-023095-4dannjjm 3581 21 T. t. NN cord-023095-4dannjjm 3581 22 gondii gondii NN cord-023095-4dannjjm 3581 23 inoculation inoculation NN cord-023095-4dannjjm 3581 24 . . . cord-023095-4dannjjm 3582 1 Group group NN cord-023095-4dannjjm 3582 2 3 3 CD cord-023095-4dannjjm 3582 3 shed shed VBD cord-023095-4dannjjm 3582 4 oocysts oocyst NNS cord-023095-4dannjjm 3582 5 for for IN cord-023095-4dannjjm 3582 6 a a DT cord-023095-4dannjjm 3582 7 significantly significantly RB cord-023095-4dannjjm 3582 8 shorter short JJR cord-023095-4dannjjm 3582 9 period period NN cord-023095-4dannjjm 3582 10 than than IN cord-023095-4dannjjm 3582 11 Groups group NNS cord-023095-4dannjjm 3582 12 1 1 CD cord-023095-4dannjjm 3582 13 or or CC cord-023095-4dannjjm 3582 14 2 2 CD cord-023095-4dannjjm 3582 15 and and CC cord-023095-4dannjjm 3582 16 had have VBD cord-023095-4dannjjm 3582 17 a a DT cord-023095-4dannjjm 3582 18 significantly significantly RB cord-023095-4dannjjm 3582 19 lower low JJR cord-023095-4dannjjm 3582 20 oocyst oocyst NN cord-023095-4dannjjm 3582 21 shedding shed VBG cord-023095-4dannjjm 3582 22 scores score NNS cord-023095-4dannjjm 3582 23 than than IN cord-023095-4dannjjm 3582 24 Groups group NNS cord-023095-4dannjjm 3582 25 1 1 CD cord-023095-4dannjjm 3582 26 and and CC cord-023095-4dannjjm 3582 27 2 2 CD cord-023095-4dannjjm 3582 28 on on IN cord-023095-4dannjjm 3582 29 days day NNS cord-023095-4dannjjm 3582 30 5 5 CD cord-023095-4dannjjm 3582 31 - - SYM cord-023095-4dannjjm 3582 32 11 11 CD cord-023095-4dannjjm 3582 33 after after IN cord-023095-4dannjjm 3582 34 T. T. NNP cord-023095-4dannjjm 3582 35 gondii gondii NN cord-023095-4dannjjm 3582 36 inoculation inoculation NN cord-023095-4dannjjm 3582 37 . . . cord-023095-4dannjjm 3583 1 Group group NN cord-023095-4dannjjm 3583 2 2 2 CD cord-023095-4dannjjm 3583 3 cats cat NNS cord-023095-4dannjjm 3583 4 had have VBD cord-023095-4dannjjm 3583 5 completed complete VBN cord-023095-4dannjjm 3583 6 the the DT cord-023095-4dannjjm 3583 7 oocyst oocyst JJ cord-023095-4dannjjm 3583 8 shedding shed VBG cord-023095-4dannjjm 3583 9 period period NN cord-023095-4dannjjm 3583 10 prior prior RB cord-023095-4dannjjm 3583 11 to to IN cord-023095-4dannjjm 3583 12 being be VBG cord-023095-4dannjjm 3583 13 administered administer VBN cord-023095-4dannjjm 3583 14 cyclosporine cyclosporine NN cord-023095-4dannjjm 3583 15 and and CC cord-023095-4dannjjm 3583 16 repeat repeat VB cord-023095-4dannjjm 3583 17 oocyst oocyst NNP cord-023095-4dannjjm 3583 18 shedding shedding NN cord-023095-4dannjjm 3583 19 was be VBD cord-023095-4dannjjm 3583 20 not not RB cord-023095-4dannjjm 3583 21 detected detect VBN cord-023095-4dannjjm 3583 22 during during IN cord-023095-4dannjjm 3583 23 administration administration NN cord-023095-4dannjjm 3583 24 of of IN cord-023095-4dannjjm 3583 25 the the DT cord-023095-4dannjjm 3583 26 drug drug NN cord-023095-4dannjjm 3583 27 . . . cord-023095-4dannjjm 3584 1 Administration administration NN cord-023095-4dannjjm 3584 2 of of IN cord-023095-4dannjjm 3584 3 cyclosporine cyclosporine NN cord-023095-4dannjjm 3584 4 prior prior RB cord-023095-4dannjjm 3584 5 to to IN cord-023095-4dannjjm 3584 6 T. t. NN cord-023095-4dannjjm 3584 7 gondii gondii NNP cord-023095-4dannjjm 3584 8 infection infection NN cord-023095-4dannjjm 3584 9 lessened lessen VBD cord-023095-4dannjjm 3584 10 oocyst oocyst NNP cord-023095-4dannjjm 3584 11 shedding shedding NN cord-023095-4dannjjm 3584 12 which which WDT cord-023095-4dannjjm 3584 13 is be VBZ cord-023095-4dannjjm 3584 14 likely likely JJ cord-023095-4dannjjm 3584 15 from from IN cord-023095-4dannjjm 3584 16 the the DT cord-023095-4dannjjm 3584 17 anti anti JJ cord-023095-4dannjjm 3584 18 - - JJ cord-023095-4dannjjm 3584 19 T. t. JJ cord-023095-4dannjjm 3584 20 gondii gondii NN cord-023095-4dannjjm 3584 21 effects effect NNS cord-023095-4dannjjm 3584 22 of of IN cord-023095-4dannjjm 3584 23 the the DT cord-023095-4dannjjm 3584 24 drug drug NN cord-023095-4dannjjm 3584 25 . . . cord-023095-4dannjjm 3585 1 Administration administration NN cord-023095-4dannjjm 3585 2 of of IN cord-023095-4dannjjm 3585 3 cyclosporine cyclosporine NN cord-023095-4dannjjm 3585 4 using use VBG cord-023095-4dannjjm 3585 5 this this DT cord-023095-4dannjjm 3585 6 protocol protocol NN cord-023095-4dannjjm 3585 7 is be VBZ cord-023095-4dannjjm 3585 8 unlikely unlikely JJ cord-023095-4dannjjm 3585 9 to to TO cord-023095-4dannjjm 3585 10 induce induce VB cord-023095-4dannjjm 3585 11 repeat repeat NN cord-023095-4dannjjm 3586 1 T. T. NNP cord-023095-4dannjjm 3586 2 gondii gondii NNP cord-023095-4dannjjm 3586 3 oocyst oocyst VBN cord-023095-4dannjjm 3586 4 shedding shed VBG cord-023095-4dannjjm 3586 5 in in IN cord-023095-4dannjjm 3586 6 client client NN cord-023095-4dannjjm 3586 7 - - HYPH cord-023095-4dannjjm 3586 8 owned own VBN cord-023095-4dannjjm 3586 9 cats cat NNS cord-023095-4dannjjm 3586 10 . . . cord-023095-4dannjjm 3587 1 Ã ã NN cord-023095-4dannjjm 3587 2 5 5 CD cord-023095-4dannjjm 3587 3 group group NN cord-023095-4dannjjm 3587 4 with with IN cord-023095-4dannjjm 3587 5 diarrhea diarrhea NN cord-023095-4dannjjm 3587 6 significantly significantly RB cord-023095-4dannjjm 3587 7 different different JJ cord-023095-4dannjjm 3587 8 than than IN cord-023095-4dannjjm 3587 9 group group NN cord-023095-4dannjjm 3587 10 with with IN cord-023095-4dannjjm 3587 11 normal normal JJ cord-023095-4dannjjm 3587 12 feces fece NNS cord-023095-4dannjjm 3588 1 P p NN cord-023095-4dannjjm 3588 2 o o NN cord-023095-4dannjjm 3588 3 0.05 0.05 CD cord-023095-4dannjjm 3588 4 known know VBN cord-023095-4dannjjm 3588 5 about about IN cord-023095-4dannjjm 3588 6 its -PRON- PRP$ cord-023095-4dannjjm 3588 7 metabolic metabolic JJ cord-023095-4dannjjm 3588 8 pathways pathway NNS cord-023095-4dannjjm 3588 9 or or CC cord-023095-4dannjjm 3588 10 mechanism mechanism NN cord-023095-4dannjjm 3588 11 of of IN cord-023095-4dannjjm 3588 12 pathogenicity pathogenicity NN cord-023095-4dannjjm 3588 13 and and CC cord-023095-4dannjjm 3588 14 whole whole JJ cord-023095-4dannjjm 3588 15 genome genome NN cord-023095-4dannjjm 3588 16 sequencing sequencing NN cord-023095-4dannjjm 3588 17 of of IN cord-023095-4dannjjm 3588 18 feline feline JJ cord-023095-4dannjjm 3588 19 hemoplasmas hemoplasmas NN cord-023095-4dannjjm 3588 20 has have VBZ cord-023095-4dannjjm 3588 21 not not RB cord-023095-4dannjjm 3588 22 yet yet RB cord-023095-4dannjjm 3588 23 been be VBN cord-023095-4dannjjm 3588 24 reported report VBN cord-023095-4dannjjm 3588 25 . . . cord-023095-4dannjjm 3589 1 The the DT cord-023095-4dannjjm 3589 2 aim aim NN cord-023095-4dannjjm 3589 3 of of IN cord-023095-4dannjjm 3589 4 this this DT cord-023095-4dannjjm 3589 5 study study NN cord-023095-4dannjjm 3589 6 was be VBD cord-023095-4dannjjm 3589 7 to to TO cord-023095-4dannjjm 3589 8 completely completely RB cord-023095-4dannjjm 3589 9 sequence sequence VB cord-023095-4dannjjm 3589 10 the the DT cord-023095-4dannjjm 3589 11 genome genome NN cord-023095-4dannjjm 3589 12 of of IN cord-023095-4dannjjm 3589 13 M. M. NNP cord-023095-4dannjjm 3589 14 haemofelis haemofelis JJ cord-023095-4dannjjm 3589 15 to to TO cord-023095-4dannjjm 3589 16 further further RB cord-023095-4dannjjm 3589 17 characterise characterise VB cord-023095-4dannjjm 3589 18 this this DT cord-023095-4dannjjm 3589 19 important important JJ cord-023095-4dannjjm 3589 20 pathogen pathogen NN cord-023095-4dannjjm 3589 21 . . . cord-023095-4dannjjm 3590 1 Mycoplasma mycoplasma NN cord-023095-4dannjjm 3590 2 haemofelis haemofeli VBD cord-023095-4dannjjm 3590 3 genomic genomic JJ cord-023095-4dannjjm 3590 4 DNA dna NN cord-023095-4dannjjm 3590 5 was be VBD cord-023095-4dannjjm 3590 6 purified purify VBN cord-023095-4dannjjm 3590 7 and and CC cord-023095-4dannjjm 3590 8 subjected subject VBN cord-023095-4dannjjm 3590 9 to to IN cord-023095-4dannjjm 3590 10 whole whole JJ cord-023095-4dannjjm 3590 11 shotgun shotgun NN cord-023095-4dannjjm 3590 12 Roche Roche NNP cord-023095-4dannjjm 3590 13 454 454 CD cord-023095-4dannjjm 3590 14 sequencing sequencing NN cord-023095-4dannjjm 3590 15 . . . cord-023095-4dannjjm 3591 1 Gaps gap NNS cord-023095-4dannjjm 3591 2 were be VBD cord-023095-4dannjjm 3591 3 closed close VBN cord-023095-4dannjjm 3591 4 using use VBG cord-023095-4dannjjm 3591 5 targeted target VBN cord-023095-4dannjjm 3591 6 PCR PCR NNP cord-023095-4dannjjm 3591 7 and and CC cord-023095-4dannjjm 3591 8 amplicon amplicon NN cord-023095-4dannjjm 3591 9 sequencing sequencing NN cord-023095-4dannjjm 3591 10 . . . cord-023095-4dannjjm 3592 1 Ribosomal ribosomal JJ cord-023095-4dannjjm 3592 2 genes gene NNS cord-023095-4dannjjm 3592 3 and and CC cord-023095-4dannjjm 3592 4 potential potential JJ cord-023095-4dannjjm 3592 5 open open JJ cord-023095-4dannjjm 3592 6 reading reading NN cord-023095-4dannjjm 3592 7 frames frame NNS cord-023095-4dannjjm 3592 8 ( ( -LRB- cord-023095-4dannjjm 3592 9 ORFs ORFs NNP cord-023095-4dannjjm 3592 10 ) ) -RRB- cord-023095-4dannjjm 3592 11 were be VBD cord-023095-4dannjjm 3592 12 predicted predict VBN cord-023095-4dannjjm 3592 13 in in IN cord-023095-4dannjjm 3592 14 silico silico NNS cord-023095-4dannjjm 3592 15 . . . cord-023095-4dannjjm 3593 1 Putative putative JJ cord-023095-4dannjjm 3593 2 ORFs orf NNS cord-023095-4dannjjm 3593 3 were be VBD cord-023095-4dannjjm 3593 4 annotated annotate VBN cord-023095-4dannjjm 3593 5 and and CC cord-023095-4dannjjm 3593 6 orthologous orthologous JJ cord-023095-4dannjjm 3593 7 groups group NNS cord-023095-4dannjjm 3593 8 identified identify VBD cord-023095-4dannjjm 3593 9 . . . cord-023095-4dannjjm 3594 1 Analysis analysis NN cord-023095-4dannjjm 3594 2 showed show VBD cord-023095-4dannjjm 3594 3 a a DT cord-023095-4dannjjm 3594 4 circular circular JJ cord-023095-4dannjjm 3594 5 genome genome NN cord-023095-4dannjjm 3594 6 of of IN cord-023095-4dannjjm 3594 7 1.15 1.15 CD cord-023095-4dannjjm 3594 8 Mbp Mbp NNP cord-023095-4dannjjm 3594 9 with with IN cord-023095-4dannjjm 3594 10 a a DT cord-023095-4dannjjm 3594 11 GC GC NNP cord-023095-4dannjjm 3594 12 content content NN cord-023095-4dannjjm 3594 13 of of IN cord-023095-4dannjjm 3594 14 38.9 38.9 CD cord-023095-4dannjjm 3594 15 % % NN cord-023095-4dannjjm 3594 16 . . . cord-023095-4dannjjm 3595 1 Thirty thirty CD cord-023095-4dannjjm 3595 2 - - HYPH cord-023095-4dannjjm 3595 3 one one CD cord-023095-4dannjjm 3595 4 transfer transfer NN cord-023095-4dannjjm 3595 5 RNAs rna NNS cord-023095-4dannjjm 3595 6 ( ( -LRB- cord-023095-4dannjjm 3595 7 tRNAs trna NNS cord-023095-4dannjjm 3595 8 ) ) -RRB- cord-023095-4dannjjm 3595 9 were be VBD cord-023095-4dannjjm 3595 10 identified identify VBN cord-023095-4dannjjm 3595 11 , , , cord-023095-4dannjjm 3595 12 accounting account VBG cord-023095-4dannjjm 3595 13 for for IN cord-023095-4dannjjm 3595 14 all all DT cord-023095-4dannjjm 3595 15 amino amino NN cord-023095-4dannjjm 3595 16 acids acid NNS cord-023095-4dannjjm 3595 17 , , , cord-023095-4dannjjm 3595 18 including include VBG cord-023095-4dannjjm 3595 19 a a DT cord-023095-4dannjjm 3595 20 tryptophan tryptophan NN cord-023095-4dannjjm 3595 21 tRNA trna NN cord-023095-4dannjjm 3595 22 for for IN cord-023095-4dannjjm 3595 23 the the DT cord-023095-4dannjjm 3595 24 opal opal NN cord-023095-4dannjjm 3595 25 codon codon NN cord-023095-4dannjjm 3595 26 ( ( -LRB- cord-023095-4dannjjm 3595 27 UGA UGA NNP cord-023095-4dannjjm 3595 28 ) ) -RRB- cord-023095-4dannjjm 3595 29 . . . cord-023095-4dannjjm 3596 1 Of of IN cord-023095-4dannjjm 3596 2 the the DT cord-023095-4dannjjm 3596 3 1,545 1,545 CD cord-023095-4dannjjm 3596 4 putative putative JJ cord-023095-4dannjjm 3596 5 proteins protein NNS cord-023095-4dannjjm 3596 6 identified identify VBN cord-023095-4dannjjm 3596 7 , , , cord-023095-4dannjjm 3596 8 328 328 CD cord-023095-4dannjjm 3596 9 ( ( -LRB- cord-023095-4dannjjm 3596 10 21.2 21.2 CD cord-023095-4dannjjm 3596 11 % % NN cord-023095-4dannjjm 3596 12 ) ) -RRB- cord-023095-4dannjjm 3596 13 matched match VBN cord-023095-4dannjjm 3596 14 to to IN cord-023095-4dannjjm 3596 15 proteins protein NNS cord-023095-4dannjjm 3596 16 from from IN cord-023095-4dannjjm 3596 17 other other JJ cord-023095-4dannjjm 3596 18 bacterial bacterial JJ cord-023095-4dannjjm 3596 19 species specie NNS cord-023095-4dannjjm 3596 20 . . . cord-023095-4dannjjm 3597 1 In in IN cord-023095-4dannjjm 3597 2 common common JJ cord-023095-4dannjjm 3597 3 with with IN cord-023095-4dannjjm 3597 4 the the DT cord-023095-4dannjjm 3597 5 pneumoniae pneumoniae NN cord-023095-4dannjjm 3597 6 group group NN cord-023095-4dannjjm 3597 7 of of IN cord-023095-4dannjjm 3597 8 mycoplasmas mycoplasmas NNP cord-023095-4dannjjm 3597 9 , , , cord-023095-4dannjjm 3597 10 the the DT cord-023095-4dannjjm 3597 11 closest close JJS cord-023095-4dannjjm 3597 12 phylogenetic phylogenetic JJ cord-023095-4dannjjm 3597 13 relatives relative NNS cord-023095-4dannjjm 3597 14 of of IN cord-023095-4dannjjm 3597 15 the the DT cord-023095-4dannjjm 3597 16 hemoplasmas hemoplasmas NNP cord-023095-4dannjjm 3597 17 , , , cord-023095-4dannjjm 3597 18 genes gene NNS cord-023095-4dannjjm 3597 19 involved involve VBN cord-023095-4dannjjm 3597 20 in in IN cord-023095-4dannjjm 3597 21 carbohydrate carbohydrate NN cord-023095-4dannjjm 3597 22 metabolism metabolism NN cord-023095-4dannjjm 3597 23 were be VBD cord-023095-4dannjjm 3597 24 limited limit VBN cord-023095-4dannjjm 3597 25 to to IN cord-023095-4dannjjm 3597 26 enzymes enzyme NNS cord-023095-4dannjjm 3597 27 of of IN cord-023095-4dannjjm 3597 28 the the DT cord-023095-4dannjjm 3597 29 glycolytic glycolytic JJ cord-023095-4dannjjm 3597 30 pathway pathway NN cord-023095-4dannjjm 3597 31 , , , cord-023095-4dannjjm 3597 32 with with IN cord-023095-4dannjjm 3597 33 glucose glucose NN cord-023095-4dannjjm 3597 34 appearing appear VBG cord-023095-4dannjjm 3597 35 to to TO cord-023095-4dannjjm 3597 36 be be VB cord-023095-4dannjjm 3597 37 the the DT cord-023095-4dannjjm 3597 38 sole sole JJ cord-023095-4dannjjm 3597 39 energy energy NN cord-023095-4dannjjm 3597 40 source source NN cord-023095-4dannjjm 3597 41 for for IN cord-023095-4dannjjm 3597 42 M. M. NNP cord-023095-4dannjjm 3597 43 haemofelis haemofelis NNP cord-023095-4dannjjm 3597 44 . . . cord-023095-4dannjjm 3598 1 The the DT cord-023095-4dannjjm 3598 2 majority majority NN cord-023095-4dannjjm 3598 3 of of IN cord-023095-4dannjjm 3598 4 the the DT cord-023095-4dannjjm 3598 5 pentose pentose NN cord-023095-4dannjjm 3598 6 phosphate phosphate NN cord-023095-4dannjjm 3598 7 pathway pathway NN cord-023095-4dannjjm 3598 8 genes gene NNS cord-023095-4dannjjm 3598 9 present present JJ cord-023095-4dannjjm 3598 10 in in IN cord-023095-4dannjjm 3598 11 other other JJ cord-023095-4dannjjm 3598 12 cultivatable cultivatable NN cord-023095-4dannjjm 3598 13 mycoplasmas mycoplasma NNS cord-023095-4dannjjm 3598 14 appear appear VBP cord-023095-4dannjjm 3598 15 to to TO cord-023095-4dannjjm 3598 16 be be VB cord-023095-4dannjjm 3598 17 incomplete incomplete JJ cord-023095-4dannjjm 3598 18 or or CC cord-023095-4dannjjm 3598 19 absent absent JJ cord-023095-4dannjjm 3598 20 in in IN cord-023095-4dannjjm 3598 21 M. M. NNP cord-023095-4dannjjm 3598 22 haemofelis haemofelis NNP cord-023095-4dannjjm 3598 23 , , , cord-023095-4dannjjm 3598 24 suggesting suggest VBG cord-023095-4dannjjm 3598 25 an an DT cord-023095-4dannjjm 3598 26 alternative alternative JJ cord-023095-4dannjjm 3598 27 mechanism mechanism NN cord-023095-4dannjjm 3598 28 for for IN cord-023095-4dannjjm 3598 29 sourcing source VBG cord-023095-4dannjjm 3598 30 purine purine NNP cord-023095-4dannjjm 3598 31 and and CC cord-023095-4dannjjm 3598 32 pyramidine pyramidine NN cord-023095-4dannjjm 3598 33 bases basis NNS cord-023095-4dannjjm 3598 34 such such JJ cord-023095-4dannjjm 3598 35 as as IN cord-023095-4dannjjm 3598 36 scavenging scavenge VBG cord-023095-4dannjjm 3598 37 from from IN cord-023095-4dannjjm 3598 38 the the DT cord-023095-4dannjjm 3598 39 host host NN cord-023095-4dannjjm 3598 40 . . . cord-023095-4dannjjm 3599 1 A a DT cord-023095-4dannjjm 3599 2 gene gene NN cord-023095-4dannjjm 3599 3 encoding encode VBG cord-023095-4dannjjm 3599 4 a a DT cord-023095-4dannjjm 3599 5 glyceraldehyde-3-phosphate glyceraldehyde-3-phosphate NNP cord-023095-4dannjjm 3599 6 dehydrogenase dehydrogenase NN cord-023095-4dannjjm 3599 7 homolog homolog NN cord-023095-4dannjjm 3599 8 of of IN cord-023095-4dannjjm 3599 9 the the DT cord-023095-4dannjjm 3599 10 immunogenic immunogenic JJ cord-023095-4dannjjm 3599 11 MSG1 MSG1 NNP cord-023095-4dannjjm 3599 12 protein protein NN cord-023095-4dannjjm 3599 13 of of IN cord-023095-4dannjjm 3599 14 Mycoplasma Mycoplasma NNP cord-023095-4dannjjm 3599 15 suis suis NN cord-023095-4dannjjm 3599 16 was be VBD cord-023095-4dannjjm 3599 17 present present JJ cord-023095-4dannjjm 3599 18 . . . cord-023095-4dannjjm 3600 1 Of of IN cord-023095-4dannjjm 3600 2 the the DT cord-023095-4dannjjm 3600 3 uncharacterized uncharacterized JJ cord-023095-4dannjjm 3600 4 hypothetical hypothetical JJ cord-023095-4dannjjm 3600 5 proteins protein NNS cord-023095-4dannjjm 3600 6 , , , cord-023095-4dannjjm 3600 7 1,115 1,115 CD cord-023095-4dannjjm 3600 8 were be VBD cord-023095-4dannjjm 3600 9 arranged arrange VBN cord-023095-4dannjjm 3600 10 in in IN cord-023095-4dannjjm 3600 11 series series NN cord-023095-4dannjjm 3600 12 of of IN cord-023095-4dannjjm 3600 13 orthologous orthologous NNP cord-023095-4dannjjm 3600 14 repeats repeat VBZ cord-023095-4dannjjm 3600 15 , , , cord-023095-4dannjjm 3600 16 or or CC cord-023095-4dannjjm 3600 17 comprised comprise VBN cord-023095-4dannjjm 3600 18 fragments fragment NNS cord-023095-4dannjjm 3600 19 there there RB cord-023095-4dannjjm 3600 20 - - : cord-023095-4dannjjm 3600 21 of of IN cord-023095-4dannjjm 3600 22 , , , cord-023095-4dannjjm 3600 23 encoding encode VBG cord-023095-4dannjjm 3600 24 putative putative JJ cord-023095-4dannjjm 3600 25 proteins protein NNS cord-023095-4dannjjm 3600 26 of of IN cord-023095-4dannjjm 3600 27 approximately approximately RB cord-023095-4dannjjm 3600 28 200 200 CD cord-023095-4dannjjm 3600 29 amino amino JJ cord-023095-4dannjjm 3600 30 acids acid NNS cord-023095-4dannjjm 3600 31 . . . cord-023095-4dannjjm 3601 1 The the DT cord-023095-4dannjjm 3601 2 predicted predict VBN cord-023095-4dannjjm 3601 3 motifs motif NNS cord-023095-4dannjjm 3601 4 of of IN cord-023095-4dannjjm 3601 5 the the DT cord-023095-4dannjjm 3601 6 majority majority NN cord-023095-4dannjjm 3601 7 of of IN cord-023095-4dannjjm 3601 8 these these DT cord-023095-4dannjjm 3601 9 putative putative JJ cord-023095-4dannjjm 3601 10 proteins protein NNS cord-023095-4dannjjm 3601 11 were be VBD cord-023095-4dannjjm 3601 12 consistent consistent JJ cord-023095-4dannjjm 3601 13 with with IN cord-023095-4dannjjm 3601 14 these these DT cord-023095-4dannjjm 3601 15 proteins protein NNS cord-023095-4dannjjm 3601 16 being be VBG cord-023095-4dannjjm 3601 17 presented present VBN cord-023095-4dannjjm 3601 18 on on IN cord-023095-4dannjjm 3601 19 the the DT cord-023095-4dannjjm 3601 20 cell cell NN cord-023095-4dannjjm 3601 21 surface surface NN cord-023095-4dannjjm 3601 22 ; ; : cord-023095-4dannjjm 3601 23 an an DT cord-023095-4dannjjm 3601 24 N n NN cord-023095-4dannjjm 3601 25 ' ' POS cord-023095-4dannjjm 3601 26 terminal terminal NN cord-023095-4dannjjm 3601 27 signal signal NN cord-023095-4dannjjm 3601 28 peptide peptide NN cord-023095-4dannjjm 3601 29 or or CC cord-023095-4dannjjm 3601 30 transmembrane transmembrane NN cord-023095-4dannjjm 3601 31 region region NN cord-023095-4dannjjm 3601 32 followed follow VBN cord-023095-4dannjjm 3601 33 by by IN cord-023095-4dannjjm 3601 34 a a DT cord-023095-4dannjjm 3601 35 non non JJ cord-023095-4dannjjm 3601 36 - - JJ cord-023095-4dannjjm 3601 37 cytoplasmic cytoplasmic JJ cord-023095-4dannjjm 3601 38 tail tail NN cord-023095-4dannjjm 3601 39 . . . cord-023095-4dannjjm 3602 1 These these DT cord-023095-4dannjjm 3602 2 data datum NNS cord-023095-4dannjjm 3602 3 have have VBP cord-023095-4dannjjm 3602 4 provided provide VBN cord-023095-4dannjjm 3602 5 valuable valuable JJ cord-023095-4dannjjm 3602 6 information information NN cord-023095-4dannjjm 3602 7 as as IN cord-023095-4dannjjm 3602 8 to to IN cord-023095-4dannjjm 3602 9 why why WRB cord-023095-4dannjjm 3602 10 this this DT cord-023095-4dannjjm 3602 11 pathogen pathogen NN cord-023095-4dannjjm 3602 12 remains remain VBZ cord-023095-4dannjjm 3602 13 highly highly RB cord-023095-4dannjjm 3602 14 fastidious fastidious JJ cord-023095-4dannjjm 3602 15 ; ; : cord-023095-4dannjjm 3602 16 it -PRON- PRP cord-023095-4dannjjm 3602 17 lacks lack VBZ cord-023095-4dannjjm 3602 18 some some DT cord-023095-4dannjjm 3602 19 of of IN cord-023095-4dannjjm 3602 20 the the DT cord-023095-4dannjjm 3602 21 metabolic metabolic JJ cord-023095-4dannjjm 3602 22 pathways pathway NNS cord-023095-4dannjjm 3602 23 found find VBN cord-023095-4dannjjm 3602 24 in in IN cord-023095-4dannjjm 3602 25 cultivatable cultivatable JJ cord-023095-4dannjjm 3602 26 mycoplasmas mycoplasmas NN cord-023095-4dannjjm 3602 27 . . . cord-023095-4dannjjm 3603 1 We -PRON- PRP cord-023095-4dannjjm 3603 2 have have VBP cord-023095-4dannjjm 3603 3 also also RB cord-023095-4dannjjm 3603 4 identified identify VBN cord-023095-4dannjjm 3603 5 a a DT cord-023095-4dannjjm 3603 6 homolog homolog NN cord-023095-4dannjjm 3603 7 of of IN cord-023095-4dannjjm 3603 8 a a DT cord-023095-4dannjjm 3603 9 known know VBN cord-023095-4dannjjm 3603 10 M. m. NN cord-023095-4dannjjm 3603 11 suis suis FW cord-023095-4dannjjm 3603 12 immunogenic immunogenic JJ cord-023095-4dannjjm 3603 13 protein protein NN cord-023095-4dannjjm 3603 14 , , , cord-023095-4dannjjm 3603 15 and and CC cord-023095-4dannjjm 3603 16 identified identify VBD cord-023095-4dannjjm 3603 17 a a DT cord-023095-4dannjjm 3603 18 potential potential JJ cord-023095-4dannjjm 3603 19 mechanism mechanism NN cord-023095-4dannjjm 3603 20 for for IN cord-023095-4dannjjm 3603 21 host host NN cord-023095-4dannjjm 3603 22 immune immune JJ cord-023095-4dannjjm 3603 23 system system NN cord-023095-4dannjjm 3603 24 evasion evasion NN cord-023095-4dannjjm 3603 25 by by IN cord-023095-4dannjjm 3603 26 way way NN cord-023095-4dannjjm 3603 27 of of IN cord-023095-4dannjjm 3603 28 highly highly RB cord-023095-4dannjjm 3603 29 repetitive repetitive JJ cord-023095-4dannjjm 3603 30 , , , cord-023095-4dannjjm 3603 31 putatively putatively RB cord-023095-4dannjjm 3603 32 surface surface NN cord-023095-4dannjjm 3603 33 - - HYPH cord-023095-4dannjjm 3603 34 expressed express VBN cord-023095-4dannjjm 3603 35 hypothetical hypothetical JJ cord-023095-4dannjjm 3603 36 proteins protein NNS cord-023095-4dannjjm 3603 37 with with IN cord-023095-4dannjjm 3603 38 variable variable JJ cord-023095-4dannjjm 3603 39 sequences sequence NNS cord-023095-4dannjjm 3603 40 . . . cord-023095-4dannjjm 3604 1 Canine canine JJ cord-023095-4dannjjm 3604 2 leptospirosis leptospirosis NN cord-023095-4dannjjm 3604 3 has have VBZ cord-023095-4dannjjm 3604 4 been be VBN cord-023095-4dannjjm 3604 5 recognized recognize VBN cord-023095-4dannjjm 3604 6 as as IN cord-023095-4dannjjm 3604 7 a a DT cord-023095-4dannjjm 3604 8 re re NN cord-023095-4dannjjm 3604 9 - - JJ cord-023095-4dannjjm 3604 10 emerging emerge VBG cord-023095-4dannjjm 3604 11 disease disease NN cord-023095-4dannjjm 3604 12 in in IN cord-023095-4dannjjm 3604 13 the the DT cord-023095-4dannjjm 3604 14 U.S. U.S. NNP cord-023095-4dannjjm 3604 15 over over IN cord-023095-4dannjjm 3604 16 the the DT cord-023095-4dannjjm 3604 17 past past JJ cord-023095-4dannjjm 3604 18 20 20 CD cord-023095-4dannjjm 3604 19 years year NNS cord-023095-4dannjjm 3604 20 , , , cord-023095-4dannjjm 3604 21 and and CC cord-023095-4dannjjm 3604 22 several several JJ cord-023095-4dannjjm 3604 23 serosurveys serosurvey NNS cord-023095-4dannjjm 3604 24 of of IN cord-023095-4dannjjm 3604 25 the the DT cord-023095-4dannjjm 3604 26 prevalence prevalence NN cord-023095-4dannjjm 3604 27 of of IN cord-023095-4dannjjm 3604 28 leptospiral leptospiral JJ cord-023095-4dannjjm 3604 29 antibodies antibody NNS cord-023095-4dannjjm 3604 30 in in IN cord-023095-4dannjjm 3604 31 dogs dog NNS cord-023095-4dannjjm 3604 32 have have VBP cord-023095-4dannjjm 3604 33 been be VBN cord-023095-4dannjjm 3604 34 published publish VBN cord-023095-4dannjjm 3604 35 during during IN cord-023095-4dannjjm 3604 36 that that DT cord-023095-4dannjjm 3604 37 time time NN cord-023095-4dannjjm 3604 38 . . . cord-023095-4dannjjm 3605 1 The the DT cord-023095-4dannjjm 3605 2 role role NN cord-023095-4dannjjm 3605 3 of of IN cord-023095-4dannjjm 3605 4 cats cat NNS cord-023095-4dannjjm 3605 5 in in IN cord-023095-4dannjjm 3605 6 the the DT cord-023095-4dannjjm 3605 7 epidemiology epidemiology NN cord-023095-4dannjjm 3605 8 of of IN cord-023095-4dannjjm 3605 9 leptospirosis leptospirosis NN cord-023095-4dannjjm 3605 10 has have VBZ cord-023095-4dannjjm 3605 11 received receive VBN cord-023095-4dannjjm 3605 12 little little JJ cord-023095-4dannjjm 3605 13 attention attention NN cord-023095-4dannjjm 3605 14 . . . cord-023095-4dannjjm 3606 1 Serosurveys Serosurveys NNP cord-023095-4dannjjm 3606 2 of of IN cord-023095-4dannjjm 3606 3 cats cat NNS cord-023095-4dannjjm 3606 4 for for IN cord-023095-4dannjjm 3606 5 exposure exposure NN cord-023095-4dannjjm 3606 6 to to IN cord-023095-4dannjjm 3606 7 or or CC cord-023095-4dannjjm 3606 8 infection infection NN cord-023095-4dannjjm 3606 9 with with IN cord-023095-4dannjjm 3606 10 leptospires leptospire NNS cord-023095-4dannjjm 3606 11 have have VBP cord-023095-4dannjjm 3606 12 been be VBN cord-023095-4dannjjm 3606 13 published publish VBN cord-023095-4dannjjm 3606 14 from from IN cord-023095-4dannjjm 3606 15 other other JJ cord-023095-4dannjjm 3606 16 geographic geographic JJ cord-023095-4dannjjm 3606 17 areas area NNS cord-023095-4dannjjm 3606 18 , , , cord-023095-4dannjjm 3606 19 but but CC cord-023095-4dannjjm 3606 20 none none NN cord-023095-4dannjjm 3606 21 for for IN cord-023095-4dannjjm 3606 22 cats cat NNS cord-023095-4dannjjm 3606 23 in in IN cord-023095-4dannjjm 3606 24 the the DT cord-023095-4dannjjm 3606 25 U.S. U.S. NNP cord-023095-4dannjjm 3606 26 in in IN cord-023095-4dannjjm 3606 27 the the DT cord-023095-4dannjjm 3606 28 past past JJ cord-023095-4dannjjm 3606 29 four four CD cord-023095-4dannjjm 3606 30 decades decade NNS cord-023095-4dannjjm 3606 31 . . . cord-023095-4dannjjm 3607 1 The the DT cord-023095-4dannjjm 3607 2 New New NNP cord-023095-4dannjjm 3607 3 England England NNP cord-023095-4dannjjm 3607 4 states state NNS cord-023095-4dannjjm 3607 5 have have VBP cord-023095-4dannjjm 3607 6 been be VBN cord-023095-4dannjjm 3607 7 found find VBN cord-023095-4dannjjm 3607 8 to to TO cord-023095-4dannjjm 3607 9 have have VB cord-023095-4dannjjm 3607 10 a a DT cord-023095-4dannjjm 3607 11 high high JJ cord-023095-4dannjjm 3607 12 incidence incidence NN cord-023095-4dannjjm 3607 13 of of IN cord-023095-4dannjjm 3607 14 canine canine JJ cord-023095-4dannjjm 3607 15 leptospirosis leptospirosis NN cord-023095-4dannjjm 3607 16 . . . cord-023095-4dannjjm 3608 1 The the DT cord-023095-4dannjjm 3608 2 purpose purpose NN cord-023095-4dannjjm 3608 3 of of IN cord-023095-4dannjjm 3608 4 this this DT cord-023095-4dannjjm 3608 5 pilot pilot NN cord-023095-4dannjjm 3608 6 study study NN cord-023095-4dannjjm 3608 7 was be VBD cord-023095-4dannjjm 3608 8 to to TO cord-023095-4dannjjm 3608 9 determine determine VB cord-023095-4dannjjm 3608 10 the the DT cord-023095-4dannjjm 3608 11 prevalence prevalence NN cord-023095-4dannjjm 3608 12 of of IN cord-023095-4dannjjm 3608 13 leptospiral leptospiral JJ cord-023095-4dannjjm 3608 14 antibodies antibody NNS cord-023095-4dannjjm 3608 15 in in IN cord-023095-4dannjjm 3608 16 a a DT cord-023095-4dannjjm 3608 17 population population NN cord-023095-4dannjjm 3608 18 of of IN cord-023095-4dannjjm 3608 19 feral feral JJ cord-023095-4dannjjm 3608 20 cats cat NNS cord-023095-4dannjjm 3608 21 in in IN cord-023095-4dannjjm 3608 22 central central JJ cord-023095-4dannjjm 3608 23 Massachusetts Massachusetts NNP cord-023095-4dannjjm 3608 24 . . . cord-023095-4dannjjm 3609 1 Blood blood NN cord-023095-4dannjjm 3609 2 was be VBD cord-023095-4dannjjm 3609 3 collected collect VBN cord-023095-4dannjjm 3609 4 from from IN cord-023095-4dannjjm 3609 5 63 63 CD cord-023095-4dannjjm 3609 6 sexually sexually RB cord-023095-4dannjjm 3609 7 intact intact JJ cord-023095-4dannjjm 3609 8 feral feral JJ cord-023095-4dannjjm 3609 9 cats cat NNS cord-023095-4dannjjm 3609 10 presented present VBN cord-023095-4dannjjm 3609 11 to to IN cord-023095-4dannjjm 3609 12 a a DT cord-023095-4dannjjm 3609 13 spay spay NN cord-023095-4dannjjm 3609 14 and and CC cord-023095-4dannjjm 3609 15 neuter neuter JJ cord-023095-4dannjjm 3609 16 program program NN cord-023095-4dannjjm 3609 17 . . . cord-023095-4dannjjm 3610 1 Microagglutination microagglutination NN cord-023095-4dannjjm 3610 2 titers titer NNS cord-023095-4dannjjm 3610 3 to to IN cord-023095-4dannjjm 3610 4 Leptospira Leptospira NNP cord-023095-4dannjjm 3610 5 serovars serovar NNS cord-023095-4dannjjm 3610 6 autumnalis autumnalis NNP cord-023095-4dannjjm 3610 7 , , , cord-023095-4dannjjm 3610 8 hardjo hardjo NNP cord-023095-4dannjjm 3610 9 , , , cord-023095-4dannjjm 3610 10 bratislava bratislava NNP cord-023095-4dannjjm 3610 11 , , , cord-023095-4dannjjm 3610 12 icterohaemorrhagiae icterohaemorrhagiae NN cord-023095-4dannjjm 3610 13 , , , cord-023095-4dannjjm 3610 14 canicola canicola NNP cord-023095-4dannjjm 3610 15 , , , cord-023095-4dannjjm 3610 16 pomona pomona NNP cord-023095-4dannjjm 3610 17 , , , cord-023095-4dannjjm 3610 18 and and CC cord-023095-4dannjjm 3610 19 grippotyphosa grippotyphosa NNP cord-023095-4dannjjm 3610 20 were be VBD cord-023095-4dannjjm 3610 21 determined determine VBN cord-023095-4dannjjm 3610 22 . . . cord-023095-4dannjjm 3611 1 Three three CD cord-023095-4dannjjm 3611 2 of of IN cord-023095-4dannjjm 3611 3 63 63 CD cord-023095-4dannjjm 3611 4 cats cat NNS cord-023095-4dannjjm 3611 5 ( ( -LRB- cord-023095-4dannjjm 3611 6 4.8 4.8 CD cord-023095-4dannjjm 3611 7 % % NN cord-023095-4dannjjm 3611 8 ) ) -RRB- cord-023095-4dannjjm 3611 9 had have VBD cord-023095-4dannjjm 3611 10 a a DT cord-023095-4dannjjm 3611 11 positive positive JJ cord-023095-4dannjjm 3611 12 titer titer NN cord-023095-4dannjjm 3611 13 to to IN cord-023095-4dannjjm 3611 14 one one CD cord-023095-4dannjjm 3611 15 or or CC cord-023095-4dannjjm 3611 16 more more JJR cord-023095-4dannjjm 3611 17 serovars serovar NNS cord-023095-4dannjjm 3611 18 , , , cord-023095-4dannjjm 3611 19 with with IN cord-023095-4dannjjm 3611 20 autumnalis autumnalis NNP cord-023095-4dannjjm 3611 21 being be VBG cord-023095-4dannjjm 3611 22 the the DT cord-023095-4dannjjm 3611 23 most most RBS cord-023095-4dannjjm 3611 24 common common JJ cord-023095-4dannjjm 3611 25 . . . cord-023095-4dannjjm 3612 1 These these DT cord-023095-4dannjjm 3612 2 results result NNS cord-023095-4dannjjm 3612 3 are be VBP cord-023095-4dannjjm 3612 4 consistent consistent JJ cord-023095-4dannjjm 3612 5 with with IN cord-023095-4dannjjm 3612 6 previously previously RB cord-023095-4dannjjm 3612 7 published publish VBN cord-023095-4dannjjm 3612 8 prevalence prevalence NN cord-023095-4dannjjm 3612 9 rates rate NNS cord-023095-4dannjjm 3612 10 in in IN cord-023095-4dannjjm 3612 11 feral feral JJ cord-023095-4dannjjm 3612 12 cats cat NNS cord-023095-4dannjjm 3612 13 . . . cord-023095-4dannjjm 3613 1 Further further JJ cord-023095-4dannjjm 3613 2 studies study NNS cord-023095-4dannjjm 3613 3 are be VBP cord-023095-4dannjjm 3613 4 required require VBN cord-023095-4dannjjm 3613 5 to to TO cord-023095-4dannjjm 3613 6 determine determine VB cord-023095-4dannjjm 3613 7 the the DT cord-023095-4dannjjm 3613 8 role role NN cord-023095-4dannjjm 3613 9 of of IN cord-023095-4dannjjm 3613 10 leptosporosis leptosporosis NN cord-023095-4dannjjm 3613 11 in in IN cord-023095-4dannjjm 3613 12 clinical clinical JJ cord-023095-4dannjjm 3613 13 disease disease NN cord-023095-4dannjjm 3613 14 in in IN cord-023095-4dannjjm 3613 15 the the DT cord-023095-4dannjjm 3613 16 domestic domestic JJ cord-023095-4dannjjm 3613 17 cat cat NN cord-023095-4dannjjm 3613 18 . . . cord-023095-4dannjjm 3614 1 Since since IN cord-023095-4dannjjm 3614 2 years year NNS cord-023095-4dannjjm 3614 3 the the DT cord-023095-4dannjjm 3614 4 Rivalta Rivalta NNP cord-023095-4dannjjm 3614 5 's 's POS cord-023095-4dannjjm 3614 6 test test NN cord-023095-4dannjjm 3614 7 is be VBZ cord-023095-4dannjjm 3614 8 routinely routinely RB cord-023095-4dannjjm 3614 9 used use VBN cord-023095-4dannjjm 3614 10 in in IN cord-023095-4dannjjm 3614 11 several several JJ cord-023095-4dannjjm 3614 12 European european JJ cord-023095-4dannjjm 3614 13 countries country NNS cord-023095-4dannjjm 3614 14 as as IN cord-023095-4dannjjm 3614 15 a a DT cord-023095-4dannjjm 3614 16 tool tool NN cord-023095-4dannjjm 3614 17 to to TO cord-023095-4dannjjm 3614 18 diagnose diagnose VB cord-023095-4dannjjm 3614 19 feline feline JJ cord-023095-4dannjjm 3614 20 infectious infectious JJ cord-023095-4dannjjm 3614 21 peritonitis peritonitis NN cord-023095-4dannjjm 3614 22 ( ( -LRB- cord-023095-4dannjjm 3614 23 FIP FIP NNP cord-023095-4dannjjm 3614 24 ) ) -RRB- cord-023095-4dannjjm 3614 25 in in IN cord-023095-4dannjjm 3614 26 cats cat NNS cord-023095-4dannjjm 3614 27 with with IN cord-023095-4dannjjm 3614 28 effusion effusion NN cord-023095-4dannjjm 3614 29 . . . cord-023095-4dannjjm 3615 1 It -PRON- PRP cord-023095-4dannjjm 3615 2 is be VBZ cord-023095-4dannjjm 3615 3 inexpensive inexpensive JJ cord-023095-4dannjjm 3615 4 and and CC cord-023095-4dannjjm 3615 5 easy easy JJ cord-023095-4dannjjm 3615 6 to to TO cord-023095-4dannjjm 3615 7 perform perform VB cord-023095-4dannjjm 3615 8 in in IN cord-023095-4dannjjm 3615 9 private private JJ cord-023095-4dannjjm 3615 10 practice practice NN cord-023095-4dannjjm 3615 11 . . . cord-023095-4dannjjm 3616 1 There there EX cord-023095-4dannjjm 3616 2 is be VBZ cord-023095-4dannjjm 3616 3 , , , cord-023095-4dannjjm 3616 4 however however RB cord-023095-4dannjjm 3616 5 , , , cord-023095-4dannjjm 3616 6 only only RB cord-023095-4dannjjm 3616 7 little little JJ cord-023095-4dannjjm 3616 8 information information NN cord-023095-4dannjjm 3616 9 about about IN cord-023095-4dannjjm 3616 10 mode mode NN cord-023095-4dannjjm 3616 11 of of IN cord-023095-4dannjjm 3616 12 action action NN cord-023095-4dannjjm 3616 13 or or CC cord-023095-4dannjjm 3616 14 its -PRON- PRP$ cord-023095-4dannjjm 3616 15 diagnostic diagnostic JJ cord-023095-4dannjjm 3616 16 value value NN cord-023095-4dannjjm 3616 17 . . . cord-023095-4dannjjm 3617 1 The the DT cord-023095-4dannjjm 3617 2 objectives objective NNS cord-023095-4dannjjm 3617 3 of of IN cord-023095-4dannjjm 3617 4 this this DT cord-023095-4dannjjm 3617 5 study study NN cord-023095-4dannjjm 3617 6 were be VBD cord-023095-4dannjjm 3617 7 to to TO cord-023095-4dannjjm 3617 8 evaluate evaluate VB cord-023095-4dannjjm 3617 9 sensitivity sensitivity NN cord-023095-4dannjjm 3617 10 , , , cord-023095-4dannjjm 3617 11 specificity specificity NN cord-023095-4dannjjm 3617 12 , , , cord-023095-4dannjjm 3617 13 positive positive JJ cord-023095-4dannjjm 3617 14 ( ( -LRB- cord-023095-4dannjjm 3617 15 PPV PPV NNP cord-023095-4dannjjm 3617 16 ) ) -RRB- cord-023095-4dannjjm 3617 17 and and CC cord-023095-4dannjjm 3617 18 negative negative JJ cord-023095-4dannjjm 3617 19 predic predic JJ cord-023095-4dannjjm 3617 20 - - HYPH cord-023095-4dannjjm 3617 21 tive tive JJ cord-023095-4dannjjm 3617 22 values value NNS cord-023095-4dannjjm 3617 23 of of IN cord-023095-4dannjjm 3617 24 the the DT cord-023095-4dannjjm 3617 25 Rivalta Rivalta NNP cord-023095-4dannjjm 3617 26 's 's POS cord-023095-4dannjjm 3617 27 test test NN cord-023095-4dannjjm 3617 28 to to IN cord-023095-4dannjjm 3617 29 diagnosis diagnosis NN cord-023095-4dannjjm 3617 30 of of IN cord-023095-4dannjjm 3617 31 FIP FIP NNP cord-023095-4dannjjm 3617 32 and and CC cord-023095-4dannjjm 3617 33 to to TO cord-023095-4dannjjm 3617 34 examine examine VB cord-023095-4dannjjm 3617 35 if if IN cord-023095-4dannjjm 3617 36 there there EX cord-023095-4dannjjm 3617 37 is be VBZ cord-023095-4dannjjm 3617 38 a a DT cord-023095-4dannjjm 3617 39 correlation correlation NN cord-023095-4dannjjm 3617 40 with with IN cord-023095-4dannjjm 3617 41 any any DT cord-023095-4dannjjm 3617 42 effusion effusion NN cord-023095-4dannjjm 3617 43 or or CC cord-023095-4dannjjm 3617 44 blood blood NN cord-023095-4dannjjm 3617 45 parameters parameter NNS cord-023095-4dannjjm 3617 46 . . . cord-023095-4dannjjm 3618 1 Medical medical JJ cord-023095-4dannjjm 3618 2 records record NNS cord-023095-4dannjjm 3618 3 of of IN cord-023095-4dannjjm 3618 4 782 782 CD cord-023095-4dannjjm 3618 5 cats cat NNS cord-023095-4dannjjm 3618 6 with with IN cord-023095-4dannjjm 3618 7 effusion effusion NN cord-023095-4dannjjm 3618 8 in in IN cord-023095-4dannjjm 3618 9 which which WDT cord-023095-4dannjjm 3618 10 the the DT cord-023095-4dannjjm 3618 11 Rivalta Rivalta NNP cord-023095-4dannjjm 3618 12 's 's POS cord-023095-4dannjjm 3618 13 test test NN cord-023095-4dannjjm 3618 14 was be VBD cord-023095-4dannjjm 3618 15 performed perform VBN cord-023095-4dannjjm 3618 16 between between IN cord-023095-4dannjjm 3618 17 1999 1999 CD cord-023095-4dannjjm 3618 18 and and CC cord-023095-4dannjjm 3618 19 2010 2010 CD cord-023095-4dannjjm 3618 20 were be VBD cord-023095-4dannjjm 3618 21 reviewed review VBN cord-023095-4dannjjm 3618 22 concerning concern VBG cord-023095-4dannjjm 3618 23 diagnosis diagnosis NN cord-023095-4dannjjm 3618 24 , , , cord-023095-4dannjjm 3618 25 blood blood NN cord-023095-4dannjjm 3618 26 and and CC cord-023095-4dannjjm 3618 27 effusion effusion NN cord-023095-4dannjjm 3618 28 parameters parameter NNS cord-023095-4dannjjm 3618 29 , , , cord-023095-4dannjjm 3618 30 and and CC cord-023095-4dannjjm 3618 31 survival survival NN cord-023095-4dannjjm 3618 32 time time NN cord-023095-4dannjjm 3618 33 . . . cord-023095-4dannjjm 3619 1 Effusion effusion NN cord-023095-4dannjjm 3619 2 and and CC cord-023095-4dannjjm 3619 3 blood blood NN cord-023095-4dannjjm 3619 4 parameters parameter NNS cord-023095-4dannjjm 3619 5 were be VBD cord-023095-4dannjjm 3619 6 compared compare VBN cord-023095-4dannjjm 3619 7 between between IN cord-023095-4dannjjm 3619 8 Rivalta Rivalta NNP cord-023095-4dannjjm 3619 9 - - HYPH cord-023095-4dannjjm 3619 10 positive positive JJ cord-023095-4dannjjm 3619 11 and and CC cord-023095-4dannjjm 3619 12 -negative -negative JJ cord-023095-4dannjjm 3619 13 effusions effusion NNS cord-023095-4dannjjm 3619 14 using use VBG cord-023095-4dannjjm 3619 15 the the DT cord-023095-4dannjjm 3619 16 Mann Mann NNP cord-023095-4dannjjm 3619 17 Whitney Whitney NNP cord-023095-4dannjjm 3619 18 U U NNP cord-023095-4dannjjm 3619 19 test test NN cord-023095-4dannjjm 3619 20 . . . cord-023095-4dannjjm 3620 1 Prevalence prevalence NN cord-023095-4dannjjm 3620 2 of of IN cord-023095-4dannjjm 3620 3 FIP fip NN cord-023095-4dannjjm 3620 4 in in IN cord-023095-4dannjjm 3620 5 cats cat NNS cord-023095-4dannjjm 3620 6 with with IN cord-023095-4dannjjm 3620 7 effusion effusion NN cord-023095-4dannjjm 3620 8 was be VBD cord-023095-4dannjjm 3620 9 31.7 31.7 CD cord-023095-4dannjjm 3620 10 % % NN cord-023095-4dannjjm 3620 11 . . . cord-023095-4dannjjm 3621 1 The the DT cord-023095-4dannjjm 3621 2 Rivalta Rivalta NNP cord-023095-4dannjjm 3621 3 's 's POS cord-023095-4dannjjm 3621 4 test test NN cord-023095-4dannjjm 3621 5 showed show VBD cord-023095-4dannjjm 3621 6 a a DT cord-023095-4dannjjm 3621 7 sensitivity sensitivity NN cord-023095-4dannjjm 3621 8 of of IN cord-023095-4dannjjm 3621 9 91.3 91.3 CD cord-023095-4dannjjm 3621 10 % % NN cord-023095-4dannjjm 3621 11 , , , cord-023095-4dannjjm 3621 12 a a DT cord-023095-4dannjjm 3621 13 specificity specificity NN cord-023095-4dannjjm 3621 14 of of IN cord-023095-4dannjjm 3621 15 66.6 66.6 CD cord-023095-4dannjjm 3621 16 % % NN cord-023095-4dannjjm 3621 17 , , , cord-023095-4dannjjm 3621 18 a a DT cord-023095-4dannjjm 3621 19 PPV PPV NNP cord-023095-4dannjjm 3621 20 of of IN cord-023095-4dannjjm 3621 21 55.9 55.9 CD cord-023095-4dannjjm 3621 22 % % NN cord-023095-4dannjjm 3621 23 , , , cord-023095-4dannjjm 3621 24 and and CC cord-023095-4dannjjm 3621 25 a a DT cord-023095-4dannjjm 3621 26 NPV NPV NNP cord-023095-4dannjjm 3621 27 of of IN cord-023095-4dannjjm 3621 28 94.3 94.3 CD cord-023095-4dannjjm 3621 29 % % NN cord-023095-4dannjjm 3621 30 for for IN cord-023095-4dannjjm 3621 31 the the DT cord-023095-4dannjjm 3621 32 diagnosis diagnosis NN cord-023095-4dannjjm 3621 33 of of IN cord-023095-4dannjjm 3621 34 FIP FIP NNP cord-023095-4dannjjm 3621 35 . . . cord-023095-4dannjjm 3622 1 The the DT cord-023095-4dannjjm 3622 2 PPV PPV NNP cord-023095-4dannjjm 3622 3 improved improve VBD cord-023095-4dannjjm 3622 4 , , , cord-023095-4dannjjm 3622 5 when when WRB cord-023095-4dannjjm 3622 6 cats cat NNS cord-023095-4dannjjm 3622 7 with with IN cord-023095-4dannjjm 3622 8 lymphoma lymphoma NN cord-023095-4dannjjm 3622 9 or or CC cord-023095-4dannjjm 3622 10 bacterial bacterial JJ cord-023095-4dannjjm 3622 11 infection infection NN cord-023095-4dannjjm 3622 12 were be VBD cord-023095-4dannjjm 3622 13 excluded exclude VBN cord-023095-4dannjjm 3622 14 ( ( -LRB- cord-023095-4dannjjm 3622 15 PPV PPV NNP cord-023095-4dannjjm 3622 16 69.2 69.2 CD cord-023095-4dannjjm 3622 17 % % NN cord-023095-4dannjjm 3622 18 ) ) -RRB- cord-023095-4dannjjm 3622 19 and and CC cord-023095-4dannjjm 3622 20 also also RB cord-023095-4dannjjm 3622 21 , , , cord-023095-4dannjjm 3622 22 when when WRB cord-023095-4dannjjm 3622 23 only only RB cord-023095-4dannjjm 3622 24 cats cat NNS cord-023095-4dannjjm 3622 25 younger young JJR cord-023095-4dannjjm 3622 26 than than IN cord-023095-4dannjjm 3622 27 2 2 CD cord-023095-4dannjjm 3622 28 years year NNS cord-023095-4dannjjm 3622 29 ( ( -LRB- cord-023095-4dannjjm 3622 30 PPV PPV NNP cord-023095-4dannjjm 3622 31 87.5 87.5 CD cord-023095-4dannjjm 3622 32 % % NN cord-023095-4dannjjm 3622 33 ) ) -RRB- cord-023095-4dannjjm 3622 34 or or CC cord-023095-4dannjjm 3622 35 1 1 CD cord-023095-4dannjjm 3622 36 year year NN cord-023095-4dannjjm 3622 37 ( ( -LRB- cord-023095-4dannjjm 3622 38 PPV PPV NNP cord-023095-4dannjjm 3622 39 90.8 90.8 CD cord-023095-4dannjjm 3622 40 % % NN cord-023095-4dannjjm 3622 41 ) ) -RRB- cord-023095-4dannjjm 3622 42 of of IN cord-023095-4dannjjm 3622 43 age age NN cord-023095-4dannjjm 3622 44 were be VBD cord-023095-4dannjjm 3622 45 included include VBN cord-023095-4dannjjm 3622 46 . . . cord-023095-4dannjjm 3623 1 The the DT cord-023095-4dannjjm 3623 2 most most RBS cord-023095-4dannjjm 3623 3 important important JJ cord-023095-4dannjjm 3623 4 significantly significantly RB cord-023095-4dannjjm 3623 5 different different JJ cord-023095-4dannjjm 3623 6 parameters parameter NNS cord-023095-4dannjjm 3623 7 between between IN cord-023095-4dannjjm 3623 8 Rivalta Rivalta NNP cord-023095-4dannjjm 3623 9 - - HYPH cord-023095-4dannjjm 3623 10 positive positive JJ cord-023095-4dannjjm 3623 11 and and CC cord-023095-4dannjjm 3623 12 -negative -negative JJ cord-023095-4dannjjm 3623 13 effusions effusion NNS cord-023095-4dannjjm 3623 14 were be VBD cord-023095-4dannjjm 3623 15 specific specific JJ cord-023095-4dannjjm 3623 16 gravity gravity NN cord-023095-4dannjjm 3623 17 as as RB cord-023095-4dannjjm 3623 18 well well RB cord-023095-4dannjjm 3623 19 as as IN cord-023095-4dannjjm 3623 20 cholesterol cholesterol NN cord-023095-4dannjjm 3623 21 , , , cord-023095-4dannjjm 3623 22 triglyceride triglyceride NN cord-023095-4dannjjm 3623 23 , , , cord-023095-4dannjjm 3623 24 and and CC cord-023095-4dannjjm 3623 25 glucose glucose NN cord-023095-4dannjjm 3623 26 concentration concentration NN cord-023095-4dannjjm 3623 27 in in IN cord-023095-4dannjjm 3623 28 the the DT cord-023095-4dannjjm 3623 29 effusion effusion NN cord-023095-4dannjjm 3623 30 . . . cord-023095-4dannjjm 3624 1 The the DT cord-023095-4dannjjm 3624 2 Rivalta Rivalta NNP cord-023095-4dannjjm 3624 3 's 's POS cord-023095-4dannjjm 3624 4 test test NN cord-023095-4dannjjm 3624 5 in in IN cord-023095-4dannjjm 3624 6 general general JJ cord-023095-4dannjjm 3624 7 is be VBZ cord-023095-4dannjjm 3624 8 a a DT cord-023095-4dannjjm 3624 9 useful useful JJ cord-023095-4dannjjm 3624 10 tool tool NN cord-023095-4dannjjm 3624 11 to to TO cord-023095-4dannjjm 3624 12 diagnose diagnose VB cord-023095-4dannjjm 3624 13 FIP FIP NNP cord-023095-4dannjjm 3624 14 , , , cord-023095-4dannjjm 3624 15 but but CC cord-023095-4dannjjm 3624 16 its -PRON- PRP$ cord-023095-4dannjjm 3624 17 sensitivity sensitivity NN cord-023095-4dannjjm 3624 18 and and CC cord-023095-4dannjjm 3624 19 specificity specificity NN cord-023095-4dannjjm 3624 20 are be VBP cord-023095-4dannjjm 3624 21 not not RB cord-023095-4dannjjm 3624 22 as as RB cord-023095-4dannjjm 3624 23 high high JJ cord-023095-4dannjjm 3624 24 as as IN cord-023095-4dannjjm 3624 25 previously previously RB cord-023095-4dannjjm 3624 26 assumed assume VBN cord-023095-4dannjjm 3624 27 . . . cord-023095-4dannjjm 3625 1 If if IN cord-023095-4dannjjm 3625 2 the the DT cord-023095-4dannjjm 3625 3 Rivalta Rivalta NNP cord-023095-4dannjjm 3625 4 's 's POS cord-023095-4dannjjm 3625 5 test test NN cord-023095-4dannjjm 3625 6 , , , cord-023095-4dannjjm 3625 7 however however RB cord-023095-4dannjjm 3625 8 , , , cord-023095-4dannjjm 3625 9 is be VBZ cord-023095-4dannjjm 3625 10 performed perform VBN cord-023095-4dannjjm 3625 11 in in IN cord-023095-4dannjjm 3625 12 young young JJ cord-023095-4dannjjm 3625 13 cats cat NNS cord-023095-4dannjjm 3625 14 or or CC cord-023095-4dannjjm 3625 15 if if IN cord-023095-4dannjjm 3625 16 certain certain JJ cord-023095-4dannjjm 3625 17 diseases disease NNS cord-023095-4dannjjm 3625 18 have have VBP cord-023095-4dannjjm 3625 19 been be VBN cord-023095-4dannjjm 3625 20 ruled rule VBN cord-023095-4dannjjm 3625 21 - - HYPH cord-023095-4dannjjm 3625 22 out out RP cord-023095-4dannjjm 3625 23 , , , cord-023095-4dannjjm 3625 24 its -PRON- PRP$ cord-023095-4dannjjm 3625 25 diagnostic diagnostic JJ cord-023095-4dannjjm 3625 26 value value NN cord-023095-4dannjjm 3625 27 is be VBZ cord-023095-4dannjjm 3625 28 high high JJ cord-023095-4dannjjm 3625 29 . . . cord-023095-4dannjjm 3626 1 Effusion Effusion NNP cord-023095-4dannjjm 3626 2 total total JJ cord-023095-4dannjjm 3626 3 protein protein NN cord-023095-4dannjjm 3626 4 is be VBZ cord-023095-4dannjjm 3626 5 not not RB cord-023095-4dannjjm 3626 6 highly highly RB cord-023095-4dannjjm 3626 7 correlated correlate VBN cord-023095-4dannjjm 3626 8 with with IN cord-023095-4dannjjm 3626 9 test test NN cord-023095-4dannjjm 3626 10 outcome outcome NN cord-023095-4dannjjm 3626 11 . . . cord-023095-4dannjjm 3627 1 Therefore therefore RB cord-023095-4dannjjm 3627 2 , , , cord-023095-4dannjjm 3627 3 it -PRON- PRP cord-023095-4dannjjm 3627 4 is be VBZ cord-023095-4dannjjm 3627 5 still still RB cord-023095-4dannjjm 3627 6 unclear unclear JJ cord-023095-4dannjjm 3627 7 , , , cord-023095-4dannjjm 3627 8 which which WDT cord-023095-4dannjjm 3627 9 components component NNS cord-023095-4dannjjm 3627 10 in in IN cord-023095-4dannjjm 3627 11 the the DT cord-023095-4dannjjm 3627 12 effusion effusion NN cord-023095-4dannjjm 3627 13 of of IN cord-023095-4dannjjm 3627 14 cats cat NNS cord-023095-4dannjjm 3627 15 with with IN cord-023095-4dannjjm 3627 16 FIP FIP NNP cord-023095-4dannjjm 3627 17 lead lead NN cord-023095-4dannjjm 3627 18 to to IN cord-023095-4dannjjm 3627 19 a a DT cord-023095-4dannjjm 3627 20 positive positive JJ cord-023095-4dannjjm 3627 21 Rivalta Rivalta NNP cord-023095-4dannjjm 3627 22 's 's POS cord-023095-4dannjjm 3627 23 test test NN cord-023095-4dannjjm 3627 24 . . . cord-023095-4dannjjm 3628 1 Canine canine JJ cord-023095-4dannjjm 3628 2 parvovirus parvovirus NN cord-023095-4dannjjm 3628 3 ( ( -LRB- cord-023095-4dannjjm 3628 4 CPV CPV NNP cord-023095-4dannjjm 3628 5 ) ) -RRB- cord-023095-4dannjjm 3628 6 and and CC cord-023095-4dannjjm 3628 7 canine canine JJ cord-023095-4dannjjm 3628 8 distemper distemper NN cord-023095-4dannjjm 3628 9 virus virus NN cord-023095-4dannjjm 3628 10 ( ( -LRB- cord-023095-4dannjjm 3628 11 CDV CDV NNP cord-023095-4dannjjm 3628 12 ) ) -RRB- cord-023095-4dannjjm 3628 13 infections infection NNS cord-023095-4dannjjm 3628 14 are be VBP cord-023095-4dannjjm 3628 15 relatively relatively RB cord-023095-4dannjjm 3628 16 common common JJ cord-023095-4dannjjm 3628 17 in in IN cord-023095-4dannjjm 3628 18 animal animal NN cord-023095-4dannjjm 3628 19 shelters shelter NNS cord-023095-4dannjjm 3628 20 and and CC cord-023095-4dannjjm 3628 21 are be VBP cord-023095-4dannjjm 3628 22 important important JJ cord-023095-4dannjjm 3628 23 population population NN cord-023095-4dannjjm 3628 24 management management NN cord-023095-4dannjjm 3628 25 issues issue NNS cord-023095-4dannjjm 3628 26 since since IN cord-023095-4dannjjm 3628 27 the the DT cord-023095-4dannjjm 3628 28 immune immune JJ cord-023095-4dannjjm 3628 29 status status NN cord-023095-4dannjjm 3628 30 of of IN cord-023095-4dannjjm 3628 31 incoming incoming JJ cord-023095-4dannjjm 3628 32 dogs dog NNS cord-023095-4dannjjm 3628 33 is be VBZ cord-023095-4dannjjm 3628 34 usually usually RB cord-023095-4dannjjm 3628 35 unknown unknown JJ cord-023095-4dannjjm 3628 36 . . . cord-023095-4dannjjm 3629 1 Our -PRON- PRP$ cord-023095-4dannjjm 3629 2 study study NN cord-023095-4dannjjm 3629 3 aimed aim VBD cord-023095-4dannjjm 3629 4 to to TO cord-023095-4dannjjm 3629 5 determine determine VB cord-023095-4dannjjm 3629 6 the the DT cord-023095-4dannjjm 3629 7 antibody antibody NN cord-023095-4dannjjm 3629 8 protection protection NN cord-023095-4dannjjm 3629 9 status status NN cord-023095-4dannjjm 3629 10 of of IN cord-023095-4dannjjm 3629 11 dogs dog NNS cord-023095-4dannjjm 3629 12 at at IN cord-023095-4dannjjm 3629 13 the the DT cord-023095-4dannjjm 3629 14 time time NN cord-023095-4dannjjm 3629 15 of of IN cord-023095-4dannjjm 3629 16 admission admission NN cord-023095-4dannjjm 3629 17 into into IN cord-023095-4dannjjm 3629 18 an an DT cord-023095-4dannjjm 3629 19 animal animal NN cord-023095-4dannjjm 3629 20 shelter shelter NN cord-023095-4dannjjm 3629 21 ( ( -LRB- cord-023095-4dannjjm 3629 22 pre pre JJ cord-023095-4dannjjm 3629 23 - - JJ cord-023095-4dannjjm 3629 24 vaccination vaccination JJ cord-023095-4dannjjm 3629 25 ) ) -RRB- cord-023095-4dannjjm 3629 26 and and CC cord-023095-4dannjjm 3629 27 over over IN cord-023095-4dannjjm 3629 28 the the DT cord-023095-4dannjjm 3629 29 following follow VBG cord-023095-4dannjjm 3629 30 2 2 CD cord-023095-4dannjjm 3629 31 weeks week NNS cord-023095-4dannjjm 3629 32 after after IN cord-023095-4dannjjm 3629 33 vaccination vaccination NN cord-023095-4dannjjm 3629 34 . . . cord-023095-4dannjjm 3630 1 Serum serum NN cord-023095-4dannjjm 3630 2 samples sample NNS cord-023095-4dannjjm 3630 3 were be VBD cord-023095-4dannjjm 3630 4 obtained obtain VBN cord-023095-4dannjjm 3630 5 from from IN cord-023095-4dannjjm 3630 6 57 57 CD cord-023095-4dannjjm 3630 7 incoming incoming JJ cord-023095-4dannjjm 3630 8 shelter shelter NN cord-023095-4dannjjm 3630 9 dogs dog NNS cord-023095-4dannjjm 3630 10 aged age VBN cord-023095-4dannjjm 3630 11 4 4 CD cord-023095-4dannjjm 3630 12 months month NNS cord-023095-4dannjjm 3630 13 and and CC cord-023095-4dannjjm 3630 14 older old JJR cord-023095-4dannjjm 3630 15 with with IN cord-023095-4dannjjm 3630 16 no no DT cord-023095-4dannjjm 3630 17 known know VBN cord-023095-4dannjjm 3630 18 history history NN cord-023095-4dannjjm 3630 19 of of IN cord-023095-4dannjjm 3630 20 vaccination vaccination NN cord-023095-4dannjjm 3630 21 . . . cord-023095-4dannjjm 3631 1 Immediately immediately RB cord-023095-4dannjjm 3631 2 following follow VBG cord-023095-4dannjjm 3631 3 serum serum NN cord-023095-4dannjjm 3631 4 collection collection NN cord-023095-4dannjjm 3631 5 , , , cord-023095-4dannjjm 3631 6 the the DT cord-023095-4dannjjm 3631 7 dogs dog NNS cord-023095-4dannjjm 3631 8 were be VBD cord-023095-4dannjjm 3631 9 vaccinated vaccinate VBN cord-023095-4dannjjm 3631 10 against against IN cord-023095-4dannjjm 3631 11 CPV CPV NNP cord-023095-4dannjjm 3631 12 and and CC cord-023095-4dannjjm 3631 13 CDV CDV NNP cord-023095-4dannjjm 3631 14 using use VBG cord-023095-4dannjjm 3631 15 a a DT cord-023095-4dannjjm 3631 16 modified modify VBN cord-023095-4dannjjm 3631 17 live live JJ cord-023095-4dannjjm 3631 18 vaccine vaccine NN cord-023095-4dannjjm 3631 19 ( ( -LRB- cord-023095-4dannjjm 3631 20 MLV MLV NNP cord-023095-4dannjjm 3631 21 ) ) -RRB- cord-023095-4dannjjm 3631 22 . . . cord-023095-4dannjjm 3632 1 CPV CPV NNP cord-023095-4dannjjm 3632 2 and and CC cord-023095-4dannjjm 3632 3 CDV CDV NNP cord-023095-4dannjjm 3632 4 antibody antibody NN cord-023095-4dannjjm 3632 5 protection protection NN cord-023095-4dannjjm 3632 6 status status NN cord-023095-4dannjjm 3632 7 was be VBD cord-023095-4dannjjm 3632 8 determined determine VBN cord-023095-4dannjjm 3632 9 using use VBG cord-023095-4dannjjm 3633 1 Synbiotics Synbiotics NNP cord-023095-4dannjjm 3633 2 TiterCHEK TiterCHEK NNP cord-023095-4dannjjm 3633 3 . . . cord-023095-4dannjjm 3633 4 Dogs dog NNS cord-023095-4dannjjm 3633 5 with with IN cord-023095-4dannjjm 3633 6 unprotective unprotective JJ cord-023095-4dannjjm 3633 7 serum serum NN cord-023095-4dannjjm 3633 8 antibody antibody NN cord-023095-4dannjjm 3633 9 levels level NNS cord-023095-4dannjjm 3633 10 against against IN cord-023095-4dannjjm 3633 11 CPV CPV NNP cord-023095-4dannjjm 3633 12 and/or and/or CC cord-023095-4dannjjm 3633 13 CDV CDV NNP cord-023095-4dannjjm 3633 14 were be VBD cord-023095-4dannjjm 3633 15 retested reteste VBN cord-023095-4dannjjm 3633 16 at at IN cord-023095-4dannjjm 3633 17 6 6 CD cord-023095-4dannjjm 3633 18 - - SYM cord-023095-4dannjjm 3633 19 8 8 CD cord-023095-4dannjjm 3633 20 days day NNS cord-023095-4dannjjm 3633 21 post post NN cord-023095-4dannjjm 3633 22 - - NN cord-023095-4dannjjm 3633 23 vaccination vaccination NN cord-023095-4dannjjm 3633 24 and and CC cord-023095-4dannjjm 3633 25 again again RB cord-023095-4dannjjm 3633 26 at at IN cord-023095-4dannjjm 3633 27 13 13 CD cord-023095-4dannjjm 3633 28 - - SYM cord-023095-4dannjjm 3633 29 15 15 CD cord-023095-4dannjjm 3633 30 days day NNS cord-023095-4dannjjm 3633 31 post post NN cord-023095-4dannjjm 3633 32 - - NN cord-023095-4dannjjm 3633 33 vaccination vaccination NN cord-023095-4dannjjm 3633 34 , , , cord-023095-4dannjjm 3633 35 if if IN cord-023095-4dannjjm 3633 36 antibody antibody NN cord-023095-4dannjjm 3633 37 levels level NNS cord-023095-4dannjjm 3633 38 were be VBD cord-023095-4dannjjm 3633 39 still still RB cord-023095-4dannjjm 3633 40 unprotective unprotective JJ cord-023095-4dannjjm 3633 41 against against IN cord-023095-4dannjjm 3633 42 CPV CPV NNP cord-023095-4dannjjm 3633 43 and and CC cord-023095-4dannjjm 3633 44 /or /or . cord-023095-4dannjjm 3633 45 CDV CDV NNP cord-023095-4dannjjm 3633 46 . . . cord-023095-4dannjjm 3634 1 At at IN cord-023095-4dannjjm 3634 2 the the DT cord-023095-4dannjjm 3634 3 conclusion conclusion NN cord-023095-4dannjjm 3634 4 of of IN cord-023095-4dannjjm 3634 5 the the DT cord-023095-4dannjjm 3634 6 study study NN cord-023095-4dannjjm 3634 7 , , , cord-023095-4dannjjm 3634 8 stored store VBN cord-023095-4dannjjm 3634 9 duplicate duplicate JJ cord-023095-4dannjjm 3634 10 sera sera NNP cord-023095-4dannjjm 3634 11 were be VBD cord-023095-4dannjjm 3634 12 submitted submit VBN cord-023095-4dannjjm 3634 13 for for IN cord-023095-4dannjjm 3634 14 batch batch NN cord-023095-4dannjjm 3634 15 ' ' `` cord-023095-4dannjjm 3634 16 gold gold NN cord-023095-4dannjjm 3634 17 standard standard NN cord-023095-4dannjjm 3634 18 ' ' '' cord-023095-4dannjjm 3634 19 testing testing NN cord-023095-4dannjjm 3634 20 to to TO cord-023095-4dannjjm 3634 21 determine determine VB cord-023095-4dannjjm 3634 22 canine canine JJ cord-023095-4dannjjm 3634 23 distemper distemper NN cord-023095-4dannjjm 3634 24 virus virus NN cord-023095-4dannjjm 3634 25 serum serum NN cord-023095-4dannjjm 3634 26 neutralization neutralization NN cord-023095-4dannjjm 3634 27 and and CC cord-023095-4dannjjm 3634 28 canine canine JJ cord-023095-4dannjjm 3634 29 parvovirus parvovirus NN cord-023095-4dannjjm 3634 30 hemagglutination hemagglutination NN cord-023095-4dannjjm 3634 31 inhibition inhibition NN cord-023095-4dannjjm 3634 32 antibody antibody NN cord-023095-4dannjjm 3634 33 titers titer NNS cord-023095-4dannjjm 3634 34 . . . cord-023095-4dannjjm 3635 1 Based base VBN cord-023095-4dannjjm 3635 2 on on IN cord-023095-4dannjjm 3635 3 the the DT cord-023095-4dannjjm 3635 4 Synbiotics Synbiotics NNP cord-023095-4dannjjm 3635 5 TiterCHEK TiterCHEK NNP cord-023095-4dannjjm 3635 6 results result VBZ cord-023095-4dannjjm 3635 7 , , , cord-023095-4dannjjm 3635 8 43/57 43/57 CD cord-023095-4dannjjm 3635 9 dogs dog NNS cord-023095-4dannjjm 3635 10 ( ( -LRB- cord-023095-4dannjjm 3635 11 75.4 75.4 CD cord-023095-4dannjjm 3635 12 % % NN cord-023095-4dannjjm 3635 13 ) ) -RRB- cord-023095-4dannjjm 3635 14 were be VBD cord-023095-4dannjjm 3635 15 protected protect VBN cord-023095-4dannjjm 3635 16 against against IN cord-023095-4dannjjm 3635 17 CPV CPV NNP cord-023095-4dannjjm 3635 18 and and CC cord-023095-4dannjjm 3635 19 21/57 21/57 CD cord-023095-4dannjjm 3635 20 ( ( -LRB- cord-023095-4dannjjm 3635 21 36.8 36.8 CD cord-023095-4dannjjm 3635 22 % % NN cord-023095-4dannjjm 3635 23 ) ) -RRB- cord-023095-4dannjjm 3635 24 were be VBD cord-023095-4dannjjm 3635 25 protected protect VBN cord-023095-4dannjjm 3635 26 against against IN cord-023095-4dannjjm 3635 27 CDV CDV NNP cord-023095-4dannjjm 3635 28 at at IN cord-023095-4dannjjm 3635 29 intake intake NN cord-023095-4dannjjm 3635 30 . . . cord-023095-4dannjjm 3636 1 Older old JJR cord-023095-4dannjjm 3636 2 incoming incoming JJ cord-023095-4dannjjm 3636 3 dogs dog NNS cord-023095-4dannjjm 3636 4 were be VBD cord-023095-4dannjjm 3636 5 more more RBR cord-023095-4dannjjm 3636 6 likely likely JJ cord-023095-4dannjjm 3636 7 to to TO cord-023095-4dannjjm 3636 8 be be VB cord-023095-4dannjjm 3636 9 protected protect VBN cord-023095-4dannjjm 3636 10 against against IN cord-023095-4dannjjm 3636 11 CPV CPV NNP cord-023095-4dannjjm 3636 12 ( ( -LRB- cord-023095-4dannjjm 3636 13 P p NN cord-023095-4dannjjm 3636 14 o o NN cord-023095-4dannjjm 3636 15 0.0001 0.0001 CD cord-023095-4dannjjm 3636 16 ) ) -RRB- cord-023095-4dannjjm 3636 17 and and CC cord-023095-4dannjjm 3636 18 CDV CDV NNP cord-023095-4dannjjm 3636 19 ( ( -LRB- cord-023095-4dannjjm 3636 20 P p NN cord-023095-4dannjjm 3636 21 5 5 CD cord-023095-4dannjjm 3636 22 0.0174 0.0174 CD cord-023095-4dannjjm 3636 23 ) ) -RRB- cord-023095-4dannjjm 3636 24 . . . cord-023095-4dannjjm 3637 1 Dogs dog NNS cord-023095-4dannjjm 3637 2 that that WDT cord-023095-4dannjjm 3637 3 were be VBD cord-023095-4dannjjm 3637 4 spayed spay VBN cord-023095-4dannjjm 3637 5 / / SYM cord-023095-4dannjjm 3637 6 neutered neuter VBN cord-023095-4dannjjm 3637 7 were be VBD cord-023095-4dannjjm 3637 8 more more RBR cord-023095-4dannjjm 3637 9 likely likely JJ cord-023095-4dannjjm 3637 10 to to TO cord-023095-4dannjjm 3637 11 be be VB cord-023095-4dannjjm 3637 12 protected protect VBN cord-023095-4dannjjm 3637 13 against against IN cord-023095-4dannjjm 3637 14 CPV cpv NN cord-023095-4dannjjm 3637 15 on on IN cord-023095-4dannjjm 3637 16 intake intake NN cord-023095-4dannjjm 3637 17 than than IN cord-023095-4dannjjm 3637 18 intact intact JJ cord-023095-4dannjjm 3637 19 animals animal NNS cord-023095-4dannjjm 3637 20 , , , cord-023095-4dannjjm 3637 21 although although IN cord-023095-4dannjjm 3637 22 this this DT cord-023095-4dannjjm 3637 23 result result NN cord-023095-4dannjjm 3637 24 was be VBD cord-023095-4dannjjm 3637 25 not not RB cord-023095-4dannjjm 3637 26 statistically statistically RB cord-023095-4dannjjm 3637 27 significant significant JJ cord-023095-4dannjjm 3637 28 ( ( -LRB- cord-023095-4dannjjm 3637 29 P p NN cord-023095-4dannjjm 3637 30 5 5 CD cord-023095-4dannjjm 3637 31 0.0627 0.0627 CD cord-023095-4dannjjm 3637 32 ) ) -RRB- cord-023095-4dannjjm 3637 33 . . . cord-023095-4dannjjm 3638 1 The the DT cord-023095-4dannjjm 3638 2 number number NN cord-023095-4dannjjm 3638 3 of of IN cord-023095-4dannjjm 3638 4 dogs dog NNS cord-023095-4dannjjm 3638 5 with with IN cord-023095-4dannjjm 3638 6 protective protective JJ cord-023095-4dannjjm 3638 7 titers titer NNS cord-023095-4dannjjm 3638 8 against against IN cord-023095-4dannjjm 3638 9 CPV CPV NNP cord-023095-4dannjjm 3638 10 / / SYM cord-023095-4dannjjm 3638 11 CDV CDV NNP cord-023095-4dannjjm 3638 12 was be VBD cord-023095-4dannjjm 3638 13 increased increase VBN cord-023095-4dannjjm 3638 14 at at IN cord-023095-4dannjjm 3638 15 6 6 CD cord-023095-4dannjjm 3638 16 - - SYM cord-023095-4dannjjm 3638 17 8 8 CD cord-023095-4dannjjm 3638 18 days day NNS cord-023095-4dannjjm 3638 19 post post NN cord-023095-4dannjjm 3638 20 - - JJ cord-023095-4dannjjm 3638 21 MLV mlv JJ cord-023095-4dannjjm 3638 22 ( ( -LRB- cord-023095-4dannjjm 3638 23 CPV CPV NNP cord-023095-4dannjjm 3638 24 -48/56 -48/56 ADD cord-023095-4dannjjm 3638 25 , , , cord-023095-4dannjjm 3638 26 85.7 85.7 CD cord-023095-4dannjjm 3638 27 % % NN cord-023095-4dannjjm 3638 28 ; ; : cord-023095-4dannjjm 3638 29 CDV CDV NNP cord-023095-4dannjjm 3638 30 -31/52 -31/52 NNP cord-023095-4dannjjm 3638 31 , , , cord-023095-4dannjjm 3638 32 59.6 59.6 CD cord-023095-4dannjjm 3638 33 % % NN cord-023095-4dannjjm 3638 34 ) ) -RRB- cord-023095-4dannjjm 3638 35 and and CC cord-023095-4dannjjm 3638 36 further further RB cord-023095-4dannjjm 3638 37 increased increase VBD cord-023095-4dannjjm 3638 38 at at IN cord-023095-4dannjjm 3638 39 13 13 CD cord-023095-4dannjjm 3638 40 - - SYM cord-023095-4dannjjm 3638 41 15 15 CD cord-023095-4dannjjm 3638 42 days day NNS cord-023095-4dannjjm 3638 43 post post NN cord-023095-4dannjjm 3638 44 - - JJ cord-023095-4dannjjm 3638 45 MLV MLV NNP cord-023095-4dannjjm 3638 46 ( ( -LRB- cord-023095-4dannjjm 3638 47 CPV CPV NNP cord-023095-4dannjjm 3638 48 -54/54 -54/54 NNP cord-023095-4dannjjm 3638 49 , , , cord-023095-4dannjjm 3638 50 100.0 100.0 CD cord-023095-4dannjjm 3638 51 % % NN cord-023095-4dannjjm 3638 52 ; ; : cord-023095-4dannjjm 3638 53 CDV CDV NNP cord-023095-4dannjjm 3638 54 -47/48 -47/48 NNPS cord-023095-4dannjjm 3638 55 , , , cord-023095-4dannjjm 3638 56 97.9 97.9 CD cord-023095-4dannjjm 3638 57 % % NN cord-023095-4dannjjm 3638 58 ) ) -RRB- cord-023095-4dannjjm 3638 59 . . . cord-023095-4dannjjm 3639 1 We -PRON- PRP cord-023095-4dannjjm 3639 2 conclude conclude VBP cord-023095-4dannjjm 3639 3 that that IN cord-023095-4dannjjm 3639 4 incoming incoming JJ cord-023095-4dannjjm 3639 5 shelter shelter NN cord-023095-4dannjjm 3639 6 dogs dog NNS cord-023095-4dannjjm 3639 7 often often RB cord-023095-4dannjjm 3639 8 do do VBP cord-023095-4dannjjm 3639 9 not not RB cord-023095-4dannjjm 3639 10 have have VB cord-023095-4dannjjm 3639 11 protective protective JJ cord-023095-4dannjjm 3639 12 antibody antibody NN cord-023095-4dannjjm 3639 13 titers titer NNS cord-023095-4dannjjm 3639 14 against against IN cord-023095-4dannjjm 3639 15 CPV CPV NNP cord-023095-4dannjjm 3639 16 and and CC cord-023095-4dannjjm 3639 17 CDV CDV NNP cord-023095-4dannjjm 3639 18 , , , cord-023095-4dannjjm 3639 19 but but CC cord-023095-4dannjjm 3639 20 older old JJR cord-023095-4dannjjm 3639 21 shelter shelter NN cord-023095-4dannjjm 3639 22 dogs dog NNS cord-023095-4dannjjm 3639 23 are be VBP cord-023095-4dannjjm 3639 24 more more RBR cord-023095-4dannjjm 3639 25 likely likely JJ cord-023095-4dannjjm 3639 26 to to TO cord-023095-4dannjjm 3639 27 be be VB cord-023095-4dannjjm 3639 28 protected protect VBN cord-023095-4dannjjm 3639 29 against against IN cord-023095-4dannjjm 3639 30 CPV CPV NNP cord-023095-4dannjjm 3639 31 . . . cord-023095-4dannjjm 3640 1 Based base VBN cord-023095-4dannjjm 3640 2 on on IN cord-023095-4dannjjm 3640 3 this this DT cord-023095-4dannjjm 3640 4 population population NN cord-023095-4dannjjm 3640 5 , , , cord-023095-4dannjjm 3640 6 we -PRON- PRP cord-023095-4dannjjm 3640 7 further further RB cord-023095-4dannjjm 3640 8 conclude conclude VBP cord-023095-4dannjjm 3640 9 that that IN cord-023095-4dannjjm 3640 10 a a DT cord-023095-4dannjjm 3640 11 large large JJ cord-023095-4dannjjm 3640 12 percentage percentage NN cord-023095-4dannjjm 3640 13 of of IN cord-023095-4dannjjm 3640 14 dogs dog NNS cord-023095-4dannjjm 3640 15 develop develop VBP cord-023095-4dannjjm 3640 16 protective protective JJ cord-023095-4dannjjm 3640 17 antibody antibody NN cord-023095-4dannjjm 3640 18 titers titer NNS cord-023095-4dannjjm 3640 19 to to IN cord-023095-4dannjjm 3640 20 CPV CPV NNP cord-023095-4dannjjm 3640 21 and and CC cord-023095-4dannjjm 3640 22 CDV CDV NNP cord-023095-4dannjjm 3640 23 within within IN cord-023095-4dannjjm 3640 24 1 1 CD cord-023095-4dannjjm 3640 25 to to IN cord-023095-4dannjjm 3640 26 2 2 CD cord-023095-4dannjjm 3640 27 weeks week NNS cord-023095-4dannjjm 3640 28 when when WRB cord-023095-4dannjjm 3640 29 vaccinated vaccinate VBN cord-023095-4dannjjm 3640 30 with with IN cord-023095-4dannjjm 3640 31 a a DT cord-023095-4dannjjm 3640 32 MLV MLV NNP cord-023095-4dannjjm 3640 33 . . . cord-023095-4dannjjm 3641 1 Mycoplasma mycoplasma NN cord-023095-4dannjjm 3641 2 spp spp NNS cord-023095-4dannjjm 3641 3 . . . cord-023095-4dannjjm 3642 1 are be VBP cord-023095-4dannjjm 3642 2 common common JJ cord-023095-4dannjjm 3642 3 inhabitants inhabitant NNS cord-023095-4dannjjm 3642 4 of of IN cord-023095-4dannjjm 3642 5 the the DT cord-023095-4dannjjm 3642 6 feline feline JJ cord-023095-4dannjjm 3642 7 oral oral JJ cord-023095-4dannjjm 3642 8 cavity cavity NN cord-023095-4dannjjm 3642 9 and and CC cord-023095-4dannjjm 3642 10 so so RB cord-023095-4dannjjm 3642 11 likely likely RB cord-023095-4dannjjm 3642 12 contaminate contaminate VB cord-023095-4dannjjm 3642 13 many many JJ cord-023095-4dannjjm 3642 14 cat cat NN cord-023095-4dannjjm 3642 15 bite bite NN cord-023095-4dannjjm 3642 16 abscesses abscess NNS cord-023095-4dannjjm 3642 17 . . . cord-023095-4dannjjm 3643 1 Mycoplasma mycoplasma NN cord-023095-4dannjjm 3643 2 spp spp NNS cord-023095-4dannjjm 3643 3 . . . cord-023095-4dannjjm 3644 1 are be VBP cord-023095-4dannjjm 3644 2 cell cell NN cord-023095-4dannjjm 3644 3 - - HYPH cord-023095-4dannjjm 3644 4 wall wall NN cord-023095-4dannjjm 3644 5 deficient deficient JJ cord-023095-4dannjjm 3644 6 and and CC cord-023095-4dannjjm 3644 7 so so RB cord-023095-4dannjjm 3644 8 do do VB cord-023095-4dannjjm 3644 9 not not RB cord-023095-4dannjjm 3644 10 respond respond VB cord-023095-4dannjjm 3644 11 to to IN cord-023095-4dannjjm 3644 12 beta beta NN cord-023095-4dannjjm 3644 13 - - HYPH cord-023095-4dannjjm 3644 14 lactam lactam NN cord-023095-4dannjjm 3644 15 class class NN cord-023095-4dannjjm 3644 16 antibiotics antibiotic NNS cord-023095-4dannjjm 3644 17 , , , cord-023095-4dannjjm 3644 18 the the DT cord-023095-4dannjjm 3644 19 class class NN cord-023095-4dannjjm 3644 20 most most RBS cord-023095-4dannjjm 3644 21 commonly commonly RB cord-023095-4dannjjm 3644 22 use use VBP cord-023095-4dannjjm 3644 23 for for IN cord-023095-4dannjjm 3644 24 the the DT cord-023095-4dannjjm 3644 25 treatment treatment NN cord-023095-4dannjjm 3644 26 of of IN cord-023095-4dannjjm 3644 27 cat cat NN cord-023095-4dannjjm 3644 28 bite bite NN cord-023095-4dannjjm 3644 29 abscesses abscess NNS cord-023095-4dannjjm 3644 30 . . . cord-023095-4dannjjm 3645 1 The the DT cord-023095-4dannjjm 3645 2 objectives objective NNS cord-023095-4dannjjm 3645 3 of of IN cord-023095-4dannjjm 3645 4 this this DT cord-023095-4dannjjm 3645 5 study study NN cord-023095-4dannjjm 3645 6 was be VBD cord-023095-4dannjjm 3645 7 to to TO cord-023095-4dannjjm 3645 8 determine determine VB cord-023095-4dannjjm 3645 9 whether whether IN cord-023095-4dannjjm 3645 10 Mycoplasma Mycoplasma NNP cord-023095-4dannjjm 3645 11 spp spp NNS cord-023095-4dannjjm 3645 12 . . . cord-023095-4dannjjm 3646 1 are be VBP cord-023095-4dannjjm 3646 2 common common JJ cord-023095-4dannjjm 3646 3 contaminants contaminant NNS cord-023095-4dannjjm 3646 4 of of IN cord-023095-4dannjjm 3646 5 cat cat NN cord-023095-4dannjjm 3646 6 bite bite NN cord-023095-4dannjjm 3646 7 abscesses abscess NNS cord-023095-4dannjjm 3646 8 and and CC cord-023095-4dannjjm 3646 9 are be VBP cord-023095-4dannjjm 3646 10 associated associate VBN cord-023095-4dannjjm 3646 11 with with IN cord-023095-4dannjjm 3646 12 beta beta NN cord-023095-4dannjjm 3646 13 - - HYPH cord-023095-4dannjjm 3646 14 lactam lactam NN cord-023095-4dannjjm 3646 15 resistant resistant JJ cord-023095-4dannjjm 3646 16 clinical clinical JJ cord-023095-4dannjjm 3646 17 disease disease NN cord-023095-4dannjjm 3646 18 . . . cord-023095-4dannjjm 3647 1 Privately privately RB cord-023095-4dannjjm 3647 2 owned own VBN cord-023095-4dannjjm 3647 3 cats cat NNS cord-023095-4dannjjm 3647 4 with with IN cord-023095-4dannjjm 3647 5 clinical clinical JJ cord-023095-4dannjjm 3647 6 evidence evidence NN cord-023095-4dannjjm 3647 7 of of IN cord-023095-4dannjjm 3647 8 an an DT cord-023095-4dannjjm 3647 9 acute acute JJ cord-023095-4dannjjm 3647 10 abscess abscess NN cord-023095-4dannjjm 3647 11 suspected suspect VBN cord-023095-4dannjjm 3647 12 to to TO cord-023095-4dannjjm 3647 13 be be VB cord-023095-4dannjjm 3647 14 from from IN cord-023095-4dannjjm 3647 15 a a DT cord-023095-4dannjjm 3647 16 cat cat NN cord-023095-4dannjjm 3647 17 bite bite NN cord-023095-4dannjjm 3647 18 were be VBD cord-023095-4dannjjm 3647 19 included include VBN cord-023095-4dannjjm 3647 20 in in IN cord-023095-4dannjjm 3647 21 the the DT cord-023095-4dannjjm 3647 22 study study NN cord-023095-4dannjjm 3647 23 . . . cord-023095-4dannjjm 3648 1 Participants participant NNS cord-023095-4dannjjm 3648 2 were be VBD cord-023095-4dannjjm 3648 3 given give VBN cord-023095-4dannjjm 3648 4 a a DT cord-023095-4dannjjm 3648 5 free free JJ cord-023095-4dannjjm 3648 6 aerobic aerobic JJ cord-023095-4dannjjm 3648 7 and and CC cord-023095-4dannjjm 3648 8 anaerobic anaerobic JJ cord-023095-4dannjjm 3648 9 culture culture NN cord-023095-4dannjjm 3648 10 as as RB cord-023095-4dannjjm 3648 11 well well RB cord-023095-4dannjjm 3648 12 as as IN cord-023095-4dannjjm 3648 13 Mycoplasma Mycoplasma NNP cord-023095-4dannjjm 3648 14 spp spp NNS cord-023095-4dannjjm 3648 15 . . . cord-023095-4dannjjm 3649 1 culture culture NN cord-023095-4dannjjm 3649 2 and and CC cord-023095-4dannjjm 3649 3 polymerase polymerase NN cord-023095-4dannjjm 3649 4 chain chain NN cord-023095-4dannjjm 3649 5 reaction reaction NN cord-023095-4dannjjm 3649 6 using use VBG cord-023095-4dannjjm 3649 7 Mycoplasma Mycoplasma NNP cord-023095-4dannjjm 3649 8 genus genus VBP cord-023095-4dannjjm 3649 9 specific specific JJ cord-023095-4dannjjm 3649 10 primers primer NNS cord-023095-4dannjjm 3649 11 . . . cord-023095-4dannjjm 3650 1 Mycoplasma mycoplasma NN cord-023095-4dannjjm 3650 2 spp spp NNS cord-023095-4dannjjm 3650 3 . . . cord-023095-4dannjjm 3651 1 amplicons amplicon NNS cord-023095-4dannjjm 3651 2 were be VBD cord-023095-4dannjjm 3651 3 sequenced sequence VBN cord-023095-4dannjjm 3651 4 to to TO cord-023095-4dannjjm 3651 5 determine determine VB cord-023095-4dannjjm 3651 6 the the DT cord-023095-4dannjjm 3651 7 species specie NNS cord-023095-4dannjjm 3651 8 . . . cord-023095-4dannjjm 3652 1 All all DT cord-023095-4dannjjm 3652 2 cats cat NNS cord-023095-4dannjjm 3652 3 were be VBD cord-023095-4dannjjm 3652 4 initially initially RB cord-023095-4dannjjm 3652 5 treated treat VBN cord-023095-4dannjjm 3652 6 with with IN cord-023095-4dannjjm 3652 7 appropriate appropriate JJ cord-023095-4dannjjm 3652 8 wound wound NN cord-023095-4dannjjm 3652 9 management management NN cord-023095-4dannjjm 3652 10 , , , cord-023095-4dannjjm 3652 11 were be VBD cord-023095-4dannjjm 3652 12 administered administer VBN cord-023095-4dannjjm 3652 13 an an DT cord-023095-4dannjjm 3652 14 antibiotic antibiotic NN cord-023095-4dannjjm 3652 15 in in IN cord-023095-4dannjjm 3652 16 the the DT cord-023095-4dannjjm 3652 17 beta beta NN cord-023095-4dannjjm 3652 18 lactam lactam NNS cord-023095-4dannjjm 3652 19 class class NN cord-023095-4dannjjm 3652 20 ( ( -LRB- cord-023095-4dannjjm 3652 21 amoxicillin amoxicillin NNP cord-023095-4dannjjm 3652 22 - - HYPH cord-023095-4dannjjm 3652 23 clavulanate clavulanate NNP cord-023095-4dannjjm 3652 24 or or CC cord-023095-4dannjjm 3652 25 cefovicin cefovicin NNP cord-023095-4dannjjm 3652 26 ) ) -RRB- cord-023095-4dannjjm 3652 27 , , , cord-023095-4dannjjm 3652 28 and and CC cord-023095-4dannjjm 3652 29 were be VBD cord-023095-4dannjjm 3652 30 rechecked rechecke VBN cord-023095-4dannjjm 3652 31 in in IN cord-023095-4dannjjm 3652 32 person person NN cord-023095-4dannjjm 3652 33 or or CC cord-023095-4dannjjm 3652 34 by by IN cord-023095-4dannjjm 3652 35 phone phone NN cord-023095-4dannjjm 3652 36 7 7 CD cord-023095-4dannjjm 3652 37 days day NNS cord-023095-4dannjjm 3652 38 after after IN cord-023095-4dannjjm 3652 39 beginning begin VBG cord-023095-4dannjjm 3652 40 treatment treatment NN cord-023095-4dannjjm 3652 41 . . . cord-023095-4dannjjm 3653 1 Of of IN cord-023095-4dannjjm 3653 2 the the DT cord-023095-4dannjjm 3653 3 26 26 CD cord-023095-4dannjjm 3653 4 cats cat NNS cord-023095-4dannjjm 3653 5 entered enter VBD cord-023095-4dannjjm 3653 6 into into IN cord-023095-4dannjjm 3653 7 the the DT cord-023095-4dannjjm 3653 8 study study NN cord-023095-4dannjjm 3653 9 to to IN cord-023095-4dannjjm 3653 10 date date NN cord-023095-4dannjjm 3653 11 , , , cord-023095-4dannjjm 3653 12 Mycoplasma mycoplasma NN cord-023095-4dannjjm 3653 13 spp spp NNS cord-023095-4dannjjm 3653 14 . . . cord-023095-4dannjjm 3653 15 were be VBD cord-023095-4dannjjm 3653 16 amplified amplify VBN cord-023095-4dannjjm 3653 17 from from IN cord-023095-4dannjjm 3653 18 4 4 CD cord-023095-4dannjjm 3653 19 cats cat NNS cord-023095-4dannjjm 3653 20 ( ( -LRB- cord-023095-4dannjjm 3653 21 15.4 15.4 CD cord-023095-4dannjjm 3653 22 % % NN cord-023095-4dannjjm 3653 23 ) ) -RRB- cord-023095-4dannjjm 3653 24 . . . cord-023095-4dannjjm 3654 1 Of of IN cord-023095-4dannjjm 3654 2 the the DT cord-023095-4dannjjm 3654 3 2 2 CD cord-023095-4dannjjm 3654 4 positive positive JJ cord-023095-4dannjjm 3654 5 samples sample NNS cord-023095-4dannjjm 3654 6 with with IN cord-023095-4dannjjm 3654 7 adequate adequate JJ cord-023095-4dannjjm 3654 8 DNA dna NN cord-023095-4dannjjm 3654 9 for for IN cord-023095-4dannjjm 3654 10 sequencing sequencing NN cord-023095-4dannjjm 3654 11 , , , cord-023095-4dannjjm 3654 12 one one CD cord-023095-4dannjjm 3654 13 was be VBD cord-023095-4dannjjm 3654 14 consistent consistent JJ cord-023095-4dannjjm 3654 15 with with IN cord-023095-4dannjjm 3654 16 M. M. NNP cord-023095-4dannjjm 3654 17 felis felis NN cord-023095-4dannjjm 3654 18 and and CC cord-023095-4dannjjm 3654 19 the the DT cord-023095-4dannjjm 3654 20 other other JJ cord-023095-4dannjjm 3654 21 was be VBD cord-023095-4dannjjm 3654 22 consistent consistent JJ cord-023095-4dannjjm 3654 23 with with IN cord-023095-4dannjjm 3654 24 M. M. NNP cord-023095-4dannjjm 3654 25 equigenitalium equigenitalium NN cord-023095-4dannjjm 3654 26 . . . cord-023095-4dannjjm 3655 1 Of of IN cord-023095-4dannjjm 3655 2 the the DT cord-023095-4dannjjm 3655 3 26 26 CD cord-023095-4dannjjm 3655 4 cats cat NNS cord-023095-4dannjjm 3655 5 , , , cord-023095-4dannjjm 3655 6 25 25 CD cord-023095-4dannjjm 3655 7 responded respond VBD cord-023095-4dannjjm 3655 8 by by IN cord-023095-4dannjjm 3655 9 Day Day NNP cord-023095-4dannjjm 3655 10 7 7 CD cord-023095-4dannjjm 3655 11 to to IN cord-023095-4dannjjm 3655 12 the the DT cord-023095-4dannjjm 3655 13 initial initial JJ cord-023095-4dannjjm 3655 14 treatment treatment NN cord-023095-4dannjjm 3655 15 , , , cord-023095-4dannjjm 3655 16 including include VBG cord-023095-4dannjjm 3655 17 3 3 CD cord-023095-4dannjjm 3655 18 of of IN cord-023095-4dannjjm 3655 19 the the DT cord-023095-4dannjjm 3655 20 4 4 CD cord-023095-4dannjjm 3655 21 Mycoplasma Mycoplasma NNP cord-023095-4dannjjm 3655 22 spp spp NNS cord-023095-4dannjjm 3655 23 . . . cord-023095-4dannjjm 3656 1 positive positive JJ cord-023095-4dannjjm 3656 2 cats cat NNS cord-023095-4dannjjm 3656 3 . . . cord-023095-4dannjjm 3657 1 The the DT cord-023095-4dannjjm 3657 2 cat cat NN cord-023095-4dannjjm 3657 3 that that WDT cord-023095-4dannjjm 3657 4 failed fail VBD cord-023095-4dannjjm 3657 5 initial initial JJ cord-023095-4dannjjm 3657 6 treatment treatment NN cord-023095-4dannjjm 3657 7 was be VBD cord-023095-4dannjjm 3657 8 positive positive JJ cord-023095-4dannjjm 3657 9 for for IN cord-023095-4dannjjm 3657 10 M. M. NNP cord-023095-4dannjjm 3657 11 equigenitalium equigenitalium NN cord-023095-4dannjjm 3657 12 on on IN cord-023095-4dannjjm 3657 13 both both DT cord-023095-4dannjjm 3657 14 Day day NN cord-023095-4dannjjm 3657 15 0 0 CD cord-023095-4dannjjm 3657 16 and and CC cord-023095-4dannjjm 3657 17 Day Day NNP cord-023095-4dannjjm 3657 18 7 7 CD cord-023095-4dannjjm 3657 19 and and CC cord-023095-4dannjjm 3657 20 ultimately ultimately RB cord-023095-4dannjjm 3657 21 responded respond VBD cord-023095-4dannjjm 3657 22 to to IN cord-023095-4dannjjm 3657 23 administration administration NN cord-023095-4dannjjm 3657 24 of of IN cord-023095-4dannjjm 3657 25 a a DT cord-023095-4dannjjm 3657 26 fluoroquinolone fluoroquinolone NN cord-023095-4dannjjm 3657 27 . . . cord-023095-4dannjjm 3658 1 The the DT cord-023095-4dannjjm 3658 2 results result NNS cord-023095-4dannjjm 3658 3 suggest suggest VBP cord-023095-4dannjjm 3658 4 that that IN cord-023095-4dannjjm 3658 5 while while IN cord-023095-4dannjjm 3658 6 Mycoplasma Mycoplasma NNP cord-023095-4dannjjm 3658 7 spp spp NNS cord-023095-4dannjjm 3658 8 . . . cord-023095-4dannjjm 3659 1 commonly commonly RB cord-023095-4dannjjm 3659 2 contaminate contaminate VB cord-023095-4dannjjm 3659 3 cat cat NN cord-023095-4dannjjm 3659 4 bite bite NN cord-023095-4dannjjm 3659 5 abscesses abscess NNS cord-023095-4dannjjm 3659 6 , , , cord-023095-4dannjjm 3659 7 routine routine JJ cord-023095-4dannjjm 3659 8 wound wound NN cord-023095-4dannjjm 3659 9 management management NN cord-023095-4dannjjm 3659 10 and and CC cord-023095-4dannjjm 3659 11 antibiotic antibiotic JJ cord-023095-4dannjjm 3659 12 therapy therapy NN cord-023095-4dannjjm 3659 13 is be VBZ cord-023095-4dannjjm 3659 14 adequate adequate JJ cord-023095-4dannjjm 3659 15 for for IN cord-023095-4dannjjm 3659 16 control control NN cord-023095-4dannjjm 3659 17 . . . cord-023095-4dannjjm 3660 1 However however RB cord-023095-4dannjjm 3660 2 , , , cord-023095-4dannjjm 3660 3 as as IN cord-023095-4dannjjm 3660 4 Mycoplasma Mycoplasma NNP cord-023095-4dannjjm 3660 5 spp spp NNS cord-023095-4dannjjm 3660 6 . . . cord-023095-4dannjjm 3661 1 infections infection NNS cord-023095-4dannjjm 3661 2 do do VBP cord-023095-4dannjjm 3661 3 not not RB cord-023095-4dannjjm 3661 4 respond respond VB cord-023095-4dannjjm 3661 5 to to IN cord-023095-4dannjjm 3661 6 beta beta NN cord-023095-4dannjjm 3661 7 lactam lactam NN cord-023095-4dannjjm 3661 8 class class NN cord-023095-4dannjjm 3661 9 antibiotic antibiotic NN cord-023095-4dannjjm 3661 10 therapy therapy NN cord-023095-4dannjjm 3661 11 , , , cord-023095-4dannjjm 3661 12 these these DT cord-023095-4dannjjm 3661 13 organisms organism NNS cord-023095-4dannjjm 3661 14 should should MD cord-023095-4dannjjm 3661 15 be be VB cord-023095-4dannjjm 3661 16 on on IN cord-023095-4dannjjm 3661 17 the the DT cord-023095-4dannjjm 3661 18 differential differential JJ cord-023095-4dannjjm 3661 19 list list NN cord-023095-4dannjjm 3661 20 for for IN cord-023095-4dannjjm 3661 21 cats cat NNS cord-023095-4dannjjm 3661 22 with with IN cord-023095-4dannjjm 3661 23 abscesses abscess NNS cord-023095-4dannjjm 3661 24 that that WDT cord-023095-4dannjjm 3661 25 fail fail VBP cord-023095-4dannjjm 3661 26 treatment treatment NN cord-023095-4dannjjm 3661 27 with with IN cord-023095-4dannjjm 3661 28 this this DT cord-023095-4dannjjm 3661 29 antibiotic antibiotic JJ cord-023095-4dannjjm 3661 30 class class NN cord-023095-4dannjjm 3661 31 . . . cord-023095-4dannjjm 3662 1 Molecular molecular JJ cord-023095-4dannjjm 3662 2 diagnostic diagnostic JJ cord-023095-4dannjjm 3662 3 assays assay NNS cord-023095-4dannjjm 3662 4 are be VBP cord-023095-4dannjjm 3662 5 frequently frequently RB cord-023095-4dannjjm 3662 6 used use VBN cord-023095-4dannjjm 3662 7 in in IN cord-023095-4dannjjm 3662 8 clinical clinical JJ cord-023095-4dannjjm 3662 9 practice practice NN cord-023095-4dannjjm 3662 10 to to TO cord-023095-4dannjjm 3662 11 aid aid VB cord-023095-4dannjjm 3662 12 in in IN cord-023095-4dannjjm 3662 13 the the DT cord-023095-4dannjjm 3662 14 diagnosis diagnosis NN cord-023095-4dannjjm 3662 15 of of IN cord-023095-4dannjjm 3662 16 suspected suspect VBN cord-023095-4dannjjm 3662 17 infectious infectious JJ cord-023095-4dannjjm 3662 18 respiratory respiratory JJ cord-023095-4dannjjm 3662 19 diseases disease NNS cord-023095-4dannjjm 3662 20 in in IN cord-023095-4dannjjm 3662 21 dogs dog NNS cord-023095-4dannjjm 3662 22 . . . cord-023095-4dannjjm 3663 1 However however RB cord-023095-4dannjjm 3663 2 , , , cord-023095-4dannjjm 3663 3 most most RBS cord-023095-4dannjjm 3663 4 currently currently RB cord-023095-4dannjjm 3663 5 available available JJ cord-023095-4dannjjm 3663 6 assays assay NNS cord-023095-4dannjjm 3663 7 can can MD cord-023095-4dannjjm 3663 8 not not RB cord-023095-4dannjjm 3663 9 distinguish distinguish VB cord-023095-4dannjjm 3663 10 strains strain NNS cord-023095-4dannjjm 3663 11 of of IN cord-023095-4dannjjm 3663 12 the the DT cord-023095-4dannjjm 3663 13 organisms organism NNS cord-023095-4dannjjm 3663 14 used use VBN cord-023095-4dannjjm 3663 15 in in IN cord-023095-4dannjjm 3663 16 vaccines vaccine NNS cord-023095-4dannjjm 3663 17 from from IN cord-023095-4dannjjm 3663 18 naturally naturally RB cord-023095-4dannjjm 3663 19 occurring occur VBG cord-023095-4dannjjm 3663 20 strains strain NNS cord-023095-4dannjjm 3663 21 . . . cord-023095-4dannjjm 3664 1 Our -PRON- PRP$ cord-023095-4dannjjm 3664 2 prior prior JJ cord-023095-4dannjjm 3664 3 studies study NNS cord-023095-4dannjjm 3664 4 demonstrated demonstrate VBD cord-023095-4dannjjm 3664 5 that that IN cord-023095-4dannjjm 3664 6 previously previously RB cord-023095-4dannjjm 3664 7 immune immune JJ cord-023095-4dannjjm 3664 8 adult adult NN cord-023095-4dannjjm 3664 9 dogs dog NNS cord-023095-4dannjjm 3664 10 are be VBP cord-023095-4dannjjm 3664 11 unlikely unlikely JJ cord-023095-4dannjjm 3664 12 to to TO cord-023095-4dannjjm 3664 13 shed shed VB cord-023095-4dannjjm 3664 14 nucleic nucleic JJ cord-023095-4dannjjm 3664 15 acids acid NNS cord-023095-4dannjjm 3664 16 of of IN cord-023095-4dannjjm 3664 17 vaccine vaccine NN cord-023095-4dannjjm 3664 18 strains strain NNS cord-023095-4dannjjm 3664 19 of of IN cord-023095-4dannjjm 3664 20 adenovirus adenovirus NN cord-023095-4dannjjm 3664 21 2 2 CD cord-023095-4dannjjm 3664 22 , , , cord-023095-4dannjjm 3664 23 parainfluenza parainfluenza NNP cord-023095-4dannjjm 3664 24 , , , cord-023095-4dannjjm 3664 25 or or CC cord-023095-4dannjjm 3664 26 Bordetella Bordetella NNP cord-023095-4dannjjm 3664 27 bronchiseptica bronchiseptica NNP cord-023095-4dannjjm 3664 28 . . . cord-023095-4dannjjm 3665 1 However however RB cord-023095-4dannjjm 3665 2 , , , cord-023095-4dannjjm 3665 3 whether whether IN cord-023095-4dannjjm 3665 4 this this DT cord-023095-4dannjjm 3665 5 is be VBZ cord-023095-4dannjjm 3665 6 true true JJ cord-023095-4dannjjm 3665 7 for for IN cord-023095-4dannjjm 3665 8 puppies puppy NNS cord-023095-4dannjjm 3665 9 is be VBZ cord-023095-4dannjjm 3665 10 unknown unknown JJ cord-023095-4dannjjm 3665 11 . . . cord-023095-4dannjjm 3666 1 Puppies puppy NNS cord-023095-4dannjjm 3666 2 ( ( -LRB- cord-023095-4dannjjm 3666 3 n n NN cord-023095-4dannjjm 3666 4 5 5 CD cord-023095-4dannjjm 3666 5 8) 8) NN cord-023095-4dannjjm 3666 6 at at IN cord-023095-4dannjjm 3666 7 a a DT cord-023095-4dannjjm 3666 8 breeding breeding NN cord-023095-4dannjjm 3666 9 facility facility NN cord-023095-4dannjjm 3666 10 were be VBD cord-023095-4dannjjm 3666 11 moved move VBN cord-023095-4dannjjm 3666 12 into into IN cord-023095-4dannjjm 3666 13 area area NN cord-023095-4dannjjm 3666 14 without without IN cord-023095-4dannjjm 3666 15 other other JJ cord-023095-4dannjjm 3666 16 dogs dog NNS cord-023095-4dannjjm 3666 17 at at IN cord-023095-4dannjjm 3666 18 6 6 CD cord-023095-4dannjjm 3666 19 weeks week NNS cord-023095-4dannjjm 3666 20 of of IN cord-023095-4dannjjm 3666 21 age age NN cord-023095-4dannjjm 3666 22 . . . cord-023095-4dannjjm 3667 1 Swabs swab NNS cord-023095-4dannjjm 3667 2 of of IN cord-023095-4dannjjm 3667 3 the the DT cord-023095-4dannjjm 3667 4 nasal nasal NN cord-023095-4dannjjm 3667 5 and and CC cord-023095-4dannjjm 3667 6 pharyngeal pharyngeal JJ cord-023095-4dannjjm 3667 7 mucosa mucosa NN cord-023095-4dannjjm 3667 8 were be VBD cord-023095-4dannjjm 3667 9 collected collect VBN cord-023095-4dannjjm 3667 10 prior prior RB cord-023095-4dannjjm 3667 11 to to IN cord-023095-4dannjjm 3667 12 vaccination vaccination NN cord-023095-4dannjjm 3667 13 and and CC cord-023095-4dannjjm 3667 14 on on IN cord-023095-4dannjjm 3667 15 days day NNS cord-023095-4dannjjm 3667 16 0 0 CD cord-023095-4dannjjm 3667 17 , , , cord-023095-4dannjjm 3667 18 1 1 CD cord-023095-4dannjjm 3667 19 , , , cord-023095-4dannjjm 3667 20 2 2 CD cord-023095-4dannjjm 3667 21 , , , cord-023095-4dannjjm 3667 22 3 3 CD cord-023095-4dannjjm 3667 23 , , , cord-023095-4dannjjm 3667 24 4 4 CD cord-023095-4dannjjm 3667 25 , , , cord-023095-4dannjjm 3667 26 5 5 CD cord-023095-4dannjjm 3667 27 , , , cord-023095-4dannjjm 3667 28 6 6 CD cord-023095-4dannjjm 3667 29 , , , cord-023095-4dannjjm 3667 30 7 7 CD cord-023095-4dannjjm 3667 31 , , , cord-023095-4dannjjm 3667 32 10 10 CD cord-023095-4dannjjm 3667 33 , , , cord-023095-4dannjjm 3667 34 14 14 CD cord-023095-4dannjjm 3667 35 , , , cord-023095-4dannjjm 3667 36 17 17 CD cord-023095-4dannjjm 3667 37 , , , cord-023095-4dannjjm 3667 38 21 21 CD cord-023095-4dannjjm 3667 39 , , , cord-023095-4dannjjm 3667 40 24 24 CD cord-023095-4dannjjm 3667 41 , , , cord-023095-4dannjjm 3667 42 and and CC cord-023095-4dannjjm 3667 43 28 28 CD cord-023095-4dannjjm 3667 44 after after IN cord-023095-4dannjjm 3667 45 vaccination vaccination NN cord-023095-4dannjjm 3667 46 with with IN cord-023095-4dannjjm 3667 47 an an DT cord-023095-4dannjjm 3667 48 intranasal intranasal NN cord-023095-4dannjjm 3667 49 adenovirus adenovirus NN cord-023095-4dannjjm 3667 50 2 2 CD cord-023095-4dannjjm 3667 51 , , , cord-023095-4dannjjm 3667 52 parainfluenza parainfluenza NNP cord-023095-4dannjjm 3667 53 , , , cord-023095-4dannjjm 3667 54 and and CC cord-023095-4dannjjm 3667 55 B. B. NNP cord-023095-4dannjjm 3667 56 bronchiseptica bronchiseptica NNP cord-023095-4dannjjm 3667 57 vaccine vaccine NN cord-023095-4dannjjm 3667 58 ( ( -LRB- cord-023095-4dannjjm 3667 59 IntraTrac IntraTrac NNP cord-023095-4dannjjm 3667 60 3 3 CD cord-023095-4dannjjm 3667 61 , , , cord-023095-4dannjjm 3667 62 Schering Schering NNP cord-023095-4dannjjm 3667 63 Plough Plough NNP cord-023095-4dannjjm 3667 64 ) ) -RRB- cord-023095-4dannjjm 3667 65 . . . cord-023095-4dannjjm 3668 1 The the DT cord-023095-4dannjjm 3668 2 swabs swab NNS cord-023095-4dannjjm 3668 3 were be VBD cord-023095-4dannjjm 3668 4 shipped ship VBN cord-023095-4dannjjm 3668 5 on on IN cord-023095-4dannjjm 3668 6 cold cold JJ cord-023095-4dannjjm 3668 7 packs pack NNS cord-023095-4dannjjm 3668 8 by by IN cord-023095-4dannjjm 3668 9 overnight overnight JJ cord-023095-4dannjjm 3668 10 express express NN cord-023095-4dannjjm 3668 11 for for IN cord-023095-4dannjjm 3668 12 DNA DNA NNP cord-023095-4dannjjm 3668 13 / / SYM cord-023095-4dannjjm 3668 14 RNA RNA NNP cord-023095-4dannjjm 3668 15 extraction extraction NN cord-023095-4dannjjm 3668 16 and and CC cord-023095-4dannjjm 3668 17 assay assay NN cord-023095-4dannjjm 3668 18 in in IN cord-023095-4dannjjm 3668 19 the the DT cord-023095-4dannjjm 3668 20 FastPanel FastPanel NNP cord-023095-4dannjjm 3668 21 TM TM NNP cord-023095-4dannjjm 3668 22 PCR PCR NNP cord-023095-4dannjjm 3668 23 Canine Canine NNP cord-023095-4dannjjm 3668 24 Respiratory Respiratory NNP cord-023095-4dannjjm 3668 25 Disease Disease NNP cord-023095-4dannjjm 3668 26 Profile Profile NNP cord-023095-4dannjjm 3668 27 at at IN cord-023095-4dannjjm 3668 28 Antech Antech NNP cord-023095-4dannjjm 3668 29 Diagnostics Diagnostics NNP cord-023095-4dannjjm 3668 30 . . . cord-023095-4dannjjm 3669 1 All all DT cord-023095-4dannjjm 3669 2 puppies puppy NNS cord-023095-4dannjjm 3669 3 were be VBD cord-023095-4dannjjm 3669 4 negative negative JJ cord-023095-4dannjjm 3669 5 for for IN cord-023095-4dannjjm 3669 6 the the DT cord-023095-4dannjjm 3669 7 infectious infectious JJ cord-023095-4dannjjm 3669 8 agents agent NNS cord-023095-4dannjjm 3669 9 prior prior RB cord-023095-4dannjjm 3669 10 to to IN cord-023095-4dannjjm 3669 11 vaccination vaccination NN cord-023095-4dannjjm 3669 12 . . . cord-023095-4dannjjm 3670 1 After after IN cord-023095-4dannjjm 3670 2 vaccination vaccination NN cord-023095-4dannjjm 3670 3 , , , cord-023095-4dannjjm 3670 4 positive positive JJ cord-023095-4dannjjm 3670 5 assay assay NN cord-023095-4dannjjm 3670 6 results result NNS cord-023095-4dannjjm 3670 7 for for IN cord-023095-4dannjjm 3670 8 parainfluenza parainfluenza NNP cord-023095-4dannjjm 3670 9 and and CC cord-023095-4dannjjm 3670 10 B. B. NNP cord-023095-4dannjjm 3670 11 bronchiseptica bronchiseptica NNP cord-023095-4dannjjm 3670 12 were be VBD cord-023095-4dannjjm 3670 13 first first RB cord-023095-4dannjjm 3670 14 detected detect VBN cord-023095-4dannjjm 3670 15 on on IN cord-023095-4dannjjm 3670 16 Day day NN cord-023095-4dannjjm 3670 17 1 1 CD cord-023095-4dannjjm 3670 18 and and CC cord-023095-4dannjjm 3670 19 on on IN cord-023095-4dannjjm 3670 20 Day day NN cord-023095-4dannjjm 3670 21 2 2 CD cord-023095-4dannjjm 3670 22 for for IN cord-023095-4dannjjm 3670 23 adenovirus adenovirus NN cord-023095-4dannjjm 3670 24 2 2 CD cord-023095-4dannjjm 3670 25 . . . cord-023095-4dannjjm 3671 1 By by IN cord-023095-4dannjjm 3671 2 Day Day NNP cord-023095-4dannjjm 3671 3 3 3 CD cord-023095-4dannjjm 3671 4 , , , cord-023095-4dannjjm 3671 5 DNA DNA NNP cord-023095-4dannjjm 3671 6 or or CC cord-023095-4dannjjm 3671 7 RNA RNA NNP cord-023095-4dannjjm 3671 8 of of IN cord-023095-4dannjjm 3671 9 the the DT cord-023095-4dannjjm 3671 10 agents agent NNS cord-023095-4dannjjm 3671 11 were be VBD cord-023095-4dannjjm 3671 12 amplified amplify VBN cord-023095-4dannjjm 3671 13 from from IN cord-023095-4dannjjm 3671 14 all all DT cord-023095-4dannjjm 3671 15 puppies puppy NNS cord-023095-4dannjjm 3671 16 from from IN cord-023095-4dannjjm 3671 17 both both CC cord-023095-4dannjjm 3671 18 sample sample NN cord-023095-4dannjjm 3671 19 sites site NNS cord-023095-4dannjjm 3671 20 and and CC cord-023095-4dannjjm 3671 21 most most JJS cord-023095-4dannjjm 3671 22 samples sample NNS cord-023095-4dannjjm 3671 23 were be VBD cord-023095-4dannjjm 3671 24 positive positive JJ cord-023095-4dannjjm 3671 25 for for IN cord-023095-4dannjjm 3671 26 all all DT cord-023095-4dannjjm 3671 27 3 3 CD cord-023095-4dannjjm 3671 28 agents agent NNS cord-023095-4dannjjm 3671 29 through through IN cord-023095-4dannjjm 3671 30 Day Day NNP cord-023095-4dannjjm 3671 31 10 10 CD cord-023095-4dannjjm 3671 32 . . . cord-023095-4dannjjm 3672 1 By by IN cord-023095-4dannjjm 3672 2 day day NN cord-023095-4dannjjm 3672 3 24 24 CD cord-023095-4dannjjm 3672 4 , , , cord-023095-4dannjjm 3672 5 only only RB cord-023095-4dannjjm 3672 6 one one CD cord-023095-4dannjjm 3672 7 dog dog NN cord-023095-4dannjjm 3672 8 was be VBD cord-023095-4dannjjm 3672 9 still still RB cord-023095-4dannjjm 3672 10 positive positive JJ cord-023095-4dannjjm 3672 11 for for IN cord-023095-4dannjjm 3672 12 B. B. NNP cord-023095-4dannjjm 3672 13 bronchiseptica bronchiseptica NNP cord-023095-4dannjjm 3672 14 . . . cord-023095-4dannjjm 3673 1 The the DT cord-023095-4dannjjm 3673 2 results result NNS cord-023095-4dannjjm 3673 3 indicate indicate VBP cord-023095-4dannjjm 3673 4 that that IN cord-023095-4dannjjm 3673 5 intranasal intranasal NNP cord-023095-4dannjjm 3673 6 administration administration NN cord-023095-4dannjjm 3673 7 of of IN cord-023095-4dannjjm 3673 8 adenovirus adenovirus NNP cord-023095-4dannjjm 3673 9 2 2 CD cord-023095-4dannjjm 3673 10 , , , cord-023095-4dannjjm 3673 11 parainfluenza parainfluenza NNP cord-023095-4dannjjm 3673 12 , , , cord-023095-4dannjjm 3673 13 or or CC cord-023095-4dannjjm 3673 14 Bordetella Bordetella NNP cord-023095-4dannjjm 3673 15 bronchiseptica bronchiseptica NNP cord-023095-4dannjjm 3673 16 vaccines vaccine NNS cord-023095-4dannjjm 3673 17 commonly commonly RB cord-023095-4dannjjm 3673 18 leads lead VBZ cord-023095-4dannjjm 3673 19 to to IN cord-023095-4dannjjm 3673 20 positive positive JJ cord-023095-4dannjjm 3673 21 molecular molecular JJ cord-023095-4dannjjm 3673 22 diagnostic diagnostic JJ cord-023095-4dannjjm 3673 23 assay assay NN cord-023095-4dannjjm 3673 24 results result VBZ cord-023095-4dannjjm 3673 25 for for IN cord-023095-4dannjjm 3673 26 a a DT cord-023095-4dannjjm 3673 27 short short JJ cord-023095-4dannjjm 3673 28 time time NN cord-023095-4dannjjm 3673 29 period period NN cord-023095-4dannjjm 3673 30 after after IN cord-023095-4dannjjm 3673 31 primary primary JJ cord-023095-4dannjjm 3673 32 vaccination vaccination NN cord-023095-4dannjjm 3673 33 . . . cord-023095-4dannjjm 3674 1 These these DT cord-023095-4dannjjm 3674 2 findings finding NNS cord-023095-4dannjjm 3674 3 should should MD cord-023095-4dannjjm 3674 4 be be VB cord-023095-4dannjjm 3674 5 considered consider VBN cord-023095-4dannjjm 3674 6 when when WRB cord-023095-4dannjjm 3674 7 assessing assess VBG cord-023095-4dannjjm 3674 8 the the DT cord-023095-4dannjjm 3674 9 results result NNS cord-023095-4dannjjm 3674 10 of of IN cord-023095-4dannjjm 3674 11 these these DT cord-023095-4dannjjm 3674 12 assays assay NNS cord-023095-4dannjjm 3674 13 in in IN cord-023095-4dannjjm 3674 14 client client NN cord-023095-4dannjjm 3674 15 - - HYPH cord-023095-4dannjjm 3674 16 owned own VBN cord-023095-4dannjjm 3674 17 puppies puppy NNS cord-023095-4dannjjm 3674 18 with with IN cord-023095-4dannjjm 3674 19 respiratory respiratory JJ cord-023095-4dannjjm 3674 20 disease disease NN cord-023095-4dannjjm 3674 21 . . . cord-023095-4dannjjm 3675 1 Antimicrobial antimicrobial JJ cord-023095-4dannjjm 3675 2 resistance resistance NN cord-023095-4dannjjm 3675 3 in in IN cord-023095-4dannjjm 3675 4 Escherichia Escherichia NNP cord-023095-4dannjjm 3675 5 coli coli NNS cord-023095-4dannjjm 3675 6 is be VBZ cord-023095-4dannjjm 3675 7 an an DT cord-023095-4dannjjm 3675 8 increasing increase VBG cord-023095-4dannjjm 3675 9 concern concern NN cord-023095-4dannjjm 3675 10 in in IN cord-023095-4dannjjm 3675 11 both both CC cord-023095-4dannjjm 3675 12 human human JJ cord-023095-4dannjjm 3675 13 and and CC cord-023095-4dannjjm 3675 14 veterinary veterinary JJ cord-023095-4dannjjm 3675 15 hospitals hospital NNS cord-023095-4dannjjm 3675 16 ' ' POS cord-023095-4dannjjm 3675 17 patients patient NNS cord-023095-4dannjjm 3675 18 . . . cord-023095-4dannjjm 3676 1 The the DT cord-023095-4dannjjm 3676 2 choice choice NN cord-023095-4dannjjm 3676 3 drug drug NN cord-023095-4dannjjm 3676 4 for for IN cord-023095-4dannjjm 3676 5 treatment treatment NN cord-023095-4dannjjm 3676 6 in in IN cord-023095-4dannjjm 3676 7 dogs dog NNS cord-023095-4dannjjm 3676 8 is be VBZ cord-023095-4dannjjm 3676 9 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 3676 10 , , , cord-023095-4dannjjm 3676 11 a a DT cord-023095-4dannjjm 3676 12 second second JJ cord-023095-4dannjjm 3676 13 generation generation NN cord-023095-4dannjjm 3676 14 fluoroquinolone fluoroquinolone NN cord-023095-4dannjjm 3676 15 ( ( -LRB- cord-023095-4dannjjm 3676 16 FQ FQ NNP cord-023095-4dannjjm 3676 17 ) ) -RRB- cord-023095-4dannjjm 3676 18 whose whose WP$ cord-023095-4dannjjm 3676 19 activity activity NN cord-023095-4dannjjm 3676 20 reflects reflect VBZ cord-023095-4dannjjm 3676 21 , , , cord-023095-4dannjjm 3676 22 in in IN cord-023095-4dannjjm 3676 23 part part NN cord-023095-4dannjjm 3676 24 , , , cord-023095-4dannjjm 3676 25 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 3676 26 . . . cord-023095-4dannjjm 3677 1 Among among IN cord-023095-4dannjjm 3677 2 the the DT cord-023095-4dannjjm 3677 3 difficulties difficulty NNS cord-023095-4dannjjm 3677 4 in in IN cord-023095-4dannjjm 3677 5 effective effective JJ cord-023095-4dannjjm 3677 6 E. E. NNP cord-023095-4dannjjm 3677 7 coli coli NNS cord-023095-4dannjjm 3677 8 treatment treatment NN cord-023095-4dannjjm 3677 9 is be VBZ cord-023095-4dannjjm 3677 10 rapid rapid JJ cord-023095-4dannjjm 3677 11 detection detection NN cord-023095-4dannjjm 3677 12 of of IN cord-023095-4dannjjm 3677 13 FQ FQ NNP cord-023095-4dannjjm 3677 14 resistance resistance NN cord-023095-4dannjjm 3677 15 . . . cord-023095-4dannjjm 3678 1 The the DT cord-023095-4dannjjm 3678 2 purpose purpose NN cord-023095-4dannjjm 3678 3 of of IN cord-023095-4dannjjm 3678 4 this this DT cord-023095-4dannjjm 3678 5 study study NN cord-023095-4dannjjm 3678 6 was be VBD cord-023095-4dannjjm 3678 7 to to TO cord-023095-4dannjjm 3678 8 determine determine VB cord-023095-4dannjjm 3678 9 the the DT cord-023095-4dannjjm 3678 10 specificity specificity NN cord-023095-4dannjjm 3678 11 and and CC cord-023095-4dannjjm 3678 12 sensitivity sensitivity NN cord-023095-4dannjjm 3678 13 of of IN cord-023095-4dannjjm 3678 14 a a DT cord-023095-4dannjjm 3678 15 FRET fret NN cord-023095-4dannjjm 3678 16 based base VBN cord-023095-4dannjjm 3678 17 assay assay NN cord-023095-4dannjjm 3678 18 for for IN cord-023095-4dannjjm 3678 19 the the DT cord-023095-4dannjjm 3678 20 rapid rapid JJ cord-023095-4dannjjm 3678 21 detection detection NN cord-023095-4dannjjm 3678 22 of of IN cord-023095-4dannjjm 3678 23 urinary urinary JJ cord-023095-4dannjjm 3678 24 tract tract NN cord-023095-4dannjjm 3678 25 infections infection NNS cord-023095-4dannjjm 3678 26 caused cause VBN cord-023095-4dannjjm 3678 27 by by IN cord-023095-4dannjjm 3678 28 FQ FQ NNP cord-023095-4dannjjm 3678 29 associated associate VBD cord-023095-4dannjjm 3678 30 multi multi JJ cord-023095-4dannjjm 3678 31 - - JJ cord-023095-4dannjjm 3678 32 drug drug JJ cord-023095-4dannjjm 3678 33 resistant resistant JJ cord-023095-4dannjjm 3678 34 E.coli E.coli NNS cord-023095-4dannjjm 3678 35 . . . cord-023095-4dannjjm 3679 1 306 306 CD cord-023095-4dannjjm 3679 2 clinical clinical JJ cord-023095-4dannjjm 3679 3 E. E. NNP cord-023095-4dannjjm 3679 4 coli coli NNS cord-023095-4dannjjm 3679 5 isolated isolate VBN cord-023095-4dannjjm 3679 6 from from IN cord-023095-4dannjjm 3679 7 canine canine JJ cord-023095-4dannjjm 3679 8 urine urine NN cord-023095-4dannjjm 3679 9 and and CC cord-023095-4dannjjm 3679 10 120 120 CD cord-023095-4dannjjm 3679 11 clinical clinical JJ cord-023095-4dannjjm 3679 12 veterinary veterinary JJ cord-023095-4dannjjm 3679 13 urine urine NN cord-023095-4dannjjm 3679 14 samples sample NNS cord-023095-4dannjjm 3679 15 being be VBG cord-023095-4dannjjm 3679 16 examined examine VBN cord-023095-4dannjjm 3679 17 for for IN cord-023095-4dannjjm 3679 18 E. E. NNP cord-023095-4dannjjm 3679 19 coli coli NNS cord-023095-4dannjjm 3679 20 were be VBD cord-023095-4dannjjm 3679 21 subjected subject VBN cord-023095-4dannjjm 3679 22 to to IN cord-023095-4dannjjm 3679 23 susceptibility susceptibility NN cord-023095-4dannjjm 3679 24 testing testing NN cord-023095-4dannjjm 3679 25 for for IN cord-023095-4dannjjm 3679 26 14 14 CD cord-023095-4dannjjm 3679 27 drugs drug NNS cord-023095-4dannjjm 3679 28 representing represent VBG cord-023095-4dannjjm 3679 29 6 6 CD cord-023095-4dannjjm 3679 30 drug drug NN cord-023095-4dannjjm 3679 31 classes class NNS cord-023095-4dannjjm 3679 32 . . . cord-023095-4dannjjm 3680 1 Pure pure JJ cord-023095-4dannjjm 3680 2 isolates isolate NNS cord-023095-4dannjjm 3680 3 were be VBD cord-023095-4dannjjm 3680 4 designated designate VBN cord-023095-4dannjjm 3680 5 NDR NDR NNP cord-023095-4dannjjm 3680 6 ( ( -LRB- cord-023095-4dannjjm 3680 7 no no DT cord-023095-4dannjjm 3680 8 drug drug NN cord-023095-4dannjjm 3680 9 resistance resistance NN cord-023095-4dannjjm 3680 10 ) ) -RRB- cord-023095-4dannjjm 3680 11 , , , cord-023095-4dannjjm 3680 12 SDR SDR NNP cord-023095-4dannjjm 3680 13 ( ( -LRB- cord-023095-4dannjjm 3680 14 single single JJ cord-023095-4dannjjm 3680 15 drug drug NN cord-023095-4dannjjm 3680 16 resistance resistance NN cord-023095-4dannjjm 3680 17 ) ) -RRB- cord-023095-4dannjjm 3680 18 and and CC cord-023095-4dannjjm 3680 19 MDR MDR NNP cord-023095-4dannjjm 3680 20 ( ( -LRB- cord-023095-4dannjjm 3680 21 multi multi JJ cord-023095-4dannjjm 3680 22 - - JJ cord-023095-4dannjjm 3680 23 drug drug JJ cord-023095-4dannjjm 3680 24 resistant resistant NN cord-023095-4dannjjm 3680 25 ) ) -RRB- cord-023095-4dannjjm 3680 26 ( ( -LRB- cord-023095-4dannjjm 3680 27 n n NN cord-023095-4dannjjm 3680 28 5 5 CD cord-023095-4dannjjm 3680 29 101 101 CD cord-023095-4dannjjm 3680 30 MDR MDR NNP cord-023095-4dannjjm 3680 31 , , , cord-023095-4dannjjm 3680 32 116 116 CD cord-023095-4dannjjm 3680 33 SDR SDR NNP cord-023095-4dannjjm 3680 34 and and CC cord-023095-4dannjjm 3680 35 89 89 CD cord-023095-4dannjjm 3680 36 NDR NDR NNP cord-023095-4dannjjm 3680 37 ) ) -RRB- cord-023095-4dannjjm 3680 38 . . . cord-023095-4dannjjm 3681 1 Minimum minimum JJ cord-023095-4dannjjm 3681 2 inhibitory inhibitory JJ cord-023095-4dannjjm 3681 3 concentration concentration NN cord-023095-4dannjjm 3681 4 ( ( -LRB- cord-023095-4dannjjm 3681 5 MIC MIC NNP cord-023095-4dannjjm 3681 6 ) ) -RRB- cord-023095-4dannjjm 3681 7 for for IN cord-023095-4dannjjm 3681 8 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 3681 9 ranged range VBD cord-023095-4dannjjm 3681 10 from from IN cord-023095-4dannjjm 3681 11 0.03 0.03 CD cord-023095-4dannjjm 3681 12 mg mg NNP cord-023095-4dannjjm 3681 13 / / SYM cord-023095-4dannjjm 3681 14 ml ml NN cord-023095-4dannjjm 3681 15 to to IN cord-023095-4dannjjm 3681 16 512 512 CD cord-023095-4dannjjm 3681 17 mg mg NNP cord-023095-4dannjjm 3681 18 / / SYM cord-023095-4dannjjm 3681 19 ml ml NNP cord-023095-4dannjjm 3681 20 , , , cord-023095-4dannjjm 3681 21 with with IN cord-023095-4dannjjm 3681 22 high high JJ cord-023095-4dannjjm 3681 23 MIC MIC NNP cord-023095-4dannjjm 3681 24 generally generally RB cord-023095-4dannjjm 3681 25 associated associate VBN cord-023095-4dannjjm 3681 26 with with IN cord-023095-4dannjjm 3681 27 MDR MDR NNP cord-023095-4dannjjm 3681 28 . . . cord-023095-4dannjjm 3682 1 Extracted extract VBN cord-023095-4dannjjm 3682 2 DNA DNA NNP cord-023095-4dannjjm 3682 3 from from IN cord-023095-4dannjjm 3682 4 culture culture NN cord-023095-4dannjjm 3682 5 and and CC cord-023095-4dannjjm 3682 6 from from IN cord-023095-4dannjjm 3682 7 urine urine NN cord-023095-4dannjjm 3682 8 were be VBD cord-023095-4dannjjm 3682 9 subjected subject VBN cord-023095-4dannjjm 3682 10 to to IN cord-023095-4dannjjm 3682 11 FRET FRET NNP cord-023095-4dannjjm 3682 12 - - HYPH cord-023095-4dannjjm 3682 13 PCR pcr NN cord-023095-4dannjjm 3682 14 targeting target VBG cord-023095-4dannjjm 3682 15 single single JJ cord-023095-4dannjjm 3682 16 nucleotide nucleotide JJ cord-023095-4dannjjm 3682 17 polymorphisms polymorphism NNS cord-023095-4dannjjm 3682 18 in in IN cord-023095-4dannjjm 3682 19 gyrA. gyrA. NNP cord-023095-4dannjjm 3683 1 The the DT cord-023095-4dannjjm 3683 2 resulting result VBG cord-023095-4dannjjm 3683 3 product product NN cord-023095-4dannjjm 3683 4 was be VBD cord-023095-4dannjjm 3683 5 sequenced sequence VBN cord-023095-4dannjjm 3683 6 to to TO cord-023095-4dannjjm 3683 7 detect detect VB cord-023095-4dannjjm 3683 8 other other JJ cord-023095-4dannjjm 3683 9 polymorphisms polymorphism NNS cord-023095-4dannjjm 3683 10 . . . cord-023095-4dannjjm 3684 1 Further further RB cord-023095-4dannjjm 3684 2 , , , cord-023095-4dannjjm 3684 3 to to TO cord-023095-4dannjjm 3684 4 determine determine VB cord-023095-4dannjjm 3684 5 the the DT cord-023095-4dannjjm 3684 6 level level NN cord-023095-4dannjjm 3684 7 of of IN cord-023095-4dannjjm 3684 8 detection detection NN cord-023095-4dannjjm 3684 9 , , , cord-023095-4dannjjm 3684 10 microbial microbial JJ cord-023095-4dannjjm 3684 11 free free JJ cord-023095-4dannjjm 3684 12 canine canine JJ cord-023095-4dannjjm 3684 13 urine urine NN cord-023095-4dannjjm 3684 14 was be VBD cord-023095-4dannjjm 3684 15 inoculated inoculate VBN cord-023095-4dannjjm 3684 16 with with IN cord-023095-4dannjjm 3684 17 10 10 CD cord-023095-4dannjjm 3684 18 6 6 CD cord-023095-4dannjjm 3684 19 to to TO cord-023095-4dannjjm 3684 20 10 10 CD cord-023095-4dannjjm 3684 21 1 1 CD cord-023095-4dannjjm 3684 22 CFU CFU NNP cord-023095-4dannjjm 3684 23 / / SYM cord-023095-4dannjjm 3684 24 ml ml NNS cord-023095-4dannjjm 3684 25 of of IN cord-023095-4dannjjm 3684 26 7 7 CD cord-023095-4dannjjm 3684 27 isolates isolate NNS cord-023095-4dannjjm 3684 28 characterized characterize VBN cord-023095-4dannjjm 3684 29 by by IN cord-023095-4dannjjm 3684 30 variable variable JJ cord-023095-4dannjjm 3684 31 susceptibility susceptibility NN cord-023095-4dannjjm 3684 32 to to IN cord-023095-4dannjjm 3684 33 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 3684 34 ( ( -LRB- cord-023095-4dannjjm 3684 35 MIC MIC NNP cord-023095-4dannjjm 3684 36 Enro Enro NNP cord-023095-4dannjjm 3684 37 5 5 CD cord-023095-4dannjjm 3684 38 0.03 0.03 CD cord-023095-4dannjjm 3684 39 , , , cord-023095-4dannjjm 3684 40 0.06 0.06 CD cord-023095-4dannjjm 3684 41 , , , cord-023095-4dannjjm 3684 42 0.15 0.15 CD cord-023095-4dannjjm 3684 43 , , , cord-023095-4dannjjm 3684 44 1 1 CD cord-023095-4dannjjm 3684 45 , , , cord-023095-4dannjjm 3684 46 64 64 CD cord-023095-4dannjjm 3684 47 , , , cord-023095-4dannjjm 3684 48 128 128 CD cord-023095-4dannjjm 3684 49 , , , cord-023095-4dannjjm 3684 50 256 256 CD cord-023095-4dannjjm 3684 51 mg mg NNP cord-023095-4dannjjm 3684 52 / / SYM cord-023095-4dannjjm 3684 53 ml ml NNP cord-023095-4dannjjm 3684 54 ) ) -RRB- cord-023095-4dannjjm 3684 55 . . . cord-023095-4dannjjm 3685 1 Of of IN cord-023095-4dannjjm 3685 2 306 306 CD cord-023095-4dannjjm 3685 3 pure pure JJ cord-023095-4dannjjm 3685 4 isolates isolate NNS cord-023095-4dannjjm 3685 5 , , , cord-023095-4dannjjm 3685 6 50 50 CD cord-023095-4dannjjm 3685 7 were be VBD cord-023095-4dannjjm 3685 8 confirmed confirm VBN cord-023095-4dannjjm 3685 9 positive positive JJ cord-023095-4dannjjm 3685 10 for for IN cord-023095-4dannjjm 3685 11 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 3685 12 resistance resistance NN cord-023095-4dannjjm 3685 13 ( ( -LRB- cord-023095-4dannjjm 3685 14 MIC MIC NNP cord-023095-4dannjjm 3685 15 Enro Enro NNP cord-023095-4dannjjm 3685 16 4 4 CD cord-023095-4dannjjm 3685 17 4 4 CD cord-023095-4dannjjm 3685 18 mg mg NNP cord-023095-4dannjjm 3685 19 / / SYM cord-023095-4dannjjm 3685 20 ml ml NNP cord-023095-4dannjjm 3685 21 ) ) -RRB- cord-023095-4dannjjm 3685 22 , , , cord-023095-4dannjjm 3685 23 43 43 CD cord-023095-4dannjjm 3685 24 of of IN cord-023095-4dannjjm 3685 25 which which WDT cord-023095-4dannjjm 3685 26 were be VBD cord-023095-4dannjjm 3685 27 positively positively RB cord-023095-4dannjjm 3685 28 identified identify VBN cord-023095-4dannjjm 3685 29 by by IN cord-023095-4dannjjm 3685 30 the the DT cord-023095-4dannjjm 3685 31 FRET FRET NNP cord-023095-4dannjjm 3685 32 - - HYPH cord-023095-4dannjjm 3685 33 PCR pcr NN cord-023095-4dannjjm 3685 34 assay assay NN cord-023095-4dannjjm 3685 35 giving give VBG cord-023095-4dannjjm 3685 36 a a DT cord-023095-4dannjjm 3685 37 sensitivity sensitivity NN cord-023095-4dannjjm 3685 38 of of IN cord-023095-4dannjjm 3685 39 86.00 86.00 CD cord-023095-4dannjjm 3685 40 % % NN cord-023095-4dannjjm 3685 41 . . . cord-023095-4dannjjm 3686 1 Only only RB cord-023095-4dannjjm 3686 2 1 1 CD cord-023095-4dannjjm 3686 3 isolate isolate NN cord-023095-4dannjjm 3686 4 that that WDT cord-023095-4dannjjm 3686 5 was be VBD cord-023095-4dannjjm 3686 6 resistant resistant JJ cord-023095-4dannjjm 3686 7 was be VBD cord-023095-4dannjjm 3686 8 not not RB cord-023095-4dannjjm 3686 9 detected detect VBN cord-023095-4dannjjm 3686 10 ( ( -LRB- cord-023095-4dannjjm 3686 11 specificity specificity NN cord-023095-4dannjjm 3686 12 of of IN cord-023095-4dannjjm 3686 13 96.66 96.66 CD cord-023095-4dannjjm 3686 14 % % NN cord-023095-4dannjjm 3686 15 ) ) -RRB- cord-023095-4dannjjm 3686 16 . . . cord-023095-4dannjjm 3687 1 However however RB cord-023095-4dannjjm 3687 2 , , , cord-023095-4dannjjm 3687 3 of of IN cord-023095-4dannjjm 3687 4 the the DT cord-023095-4dannjjm 3687 5 isolates isolate NNS cord-023095-4dannjjm 3687 6 expressing express VBG cord-023095-4dannjjm 3687 7 high high JJ cord-023095-4dannjjm 3687 8 level level NN cord-023095-4dannjjm 3687 9 resistance resistance NN cord-023095-4dannjjm 3687 10 ( ( -LRB- cord-023095-4dannjjm 3687 11 MIC MIC NNP cord-023095-4dannjjm 3687 12 4 4 CD cord-023095-4dannjjm 3687 13 8 8 CD cord-023095-4dannjjm 3687 14 X x NN cord-023095-4dannjjm 3687 15 breakpoint breakpoint NN cord-023095-4dannjjm 3687 16 [ [ -LRB- cord-023095-4dannjjm 3687 17 64 64 CD cord-023095-4dannjjm 3687 18 mcg mcg NN cord-023095-4dannjjm 3687 19 / / SYM cord-023095-4dannjjm 3687 20 ml ml NN cord-023095-4dannjjm 3687 21 ] ] -RRB- cord-023095-4dannjjm 3687 22 ) ) -RRB- cord-023095-4dannjjm 3687 23 , , , cord-023095-4dannjjm 3687 24 and and CC cord-023095-4dannjjm 3687 25 MDR MDR NNP cord-023095-4dannjjm 3687 26 ( ( -LRB- cord-023095-4dannjjm 3687 27 n n NN cord-023095-4dannjjm 3687 28 5 5 CD cord-023095-4dannjjm 3687 29 34 34 CD cord-023095-4dannjjm 3687 30 ) ) -RRB- cord-023095-4dannjjm 3687 31 , , , cord-023095-4dannjjm 3687 32 sensitivity sensitivity NN cord-023095-4dannjjm 3687 33 5 5 CD cord-023095-4dannjjm 3687 34 97.06 97.06 CD cord-023095-4dannjjm 3687 35 % % NN cord-023095-4dannjjm 3687 36 . . . cord-023095-4dannjjm 3688 1 Of of IN cord-023095-4dannjjm 3688 2 the the DT cord-023095-4dannjjm 3688 3 120 120 CD cord-023095-4dannjjm 3688 4 urine urine NN cord-023095-4dannjjm 3688 5 samples sample NNS cord-023095-4dannjjm 3688 6 27 27 CD cord-023095-4dannjjm 3688 7 contained contain VBD cord-023095-4dannjjm 3688 8 E. E. NNP cord-023095-4dannjjm 3688 9 coli coli NNS cord-023095-4dannjjm 3688 10 7 7 CD cord-023095-4dannjjm 3688 11 of of IN cord-023095-4dannjjm 3688 12 which which WDT cord-023095-4dannjjm 3688 13 determined determine VBD cord-023095-4dannjjm 3688 14 to to TO cord-023095-4dannjjm 3688 15 be be VB cord-023095-4dannjjm 3688 16 FQ FQ NNP cord-023095-4dannjjm 3688 17 - - HYPH cord-023095-4dannjjm 3688 18 resistant resistant JJ cord-023095-4dannjjm 3688 19 by by IN cord-023095-4dannjjm 3688 20 the the DT cord-023095-4dannjjm 3688 21 assay assay NN cord-023095-4dannjjm 3688 22 . . . cord-023095-4dannjjm 3689 1 Colony colony NN cord-023095-4dannjjm 3689 2 dilutions dilution NNS cord-023095-4dannjjm 3689 3 of of IN cord-023095-4dannjjm 3689 4 E. E. NNP cord-023095-4dannjjm 3689 5 coli coli NNS cord-023095-4dannjjm 3689 6 confirmed confirm VBD cord-023095-4dannjjm 3689 7 the the DT cord-023095-4dannjjm 3689 8 assay assay NN cord-023095-4dannjjm 3689 9 able able JJ cord-023095-4dannjjm 3689 10 to to TO cord-023095-4dannjjm 3689 11 detect detect VB cord-023095-4dannjjm 3689 12 enrofloxacin enrofloxacin JJ cord-023095-4dannjjm 3689 13 resistance resistance NN cord-023095-4dannjjm 3689 14 at at IN cord-023095-4dannjjm 3689 15 as as RB cord-023095-4dannjjm 3689 16 low low JJ cord-023095-4dannjjm 3689 17 as as IN cord-023095-4dannjjm 3689 18 101 101 CD cord-023095-4dannjjm 3689 19 CFU CFU NNP cord-023095-4dannjjm 3689 20 / / SYM cord-023095-4dannjjm 3689 21 ml ml NN cord-023095-4dannjjm 3689 22 . . . cord-023095-4dannjjm 3690 1 The the DT cord-023095-4dannjjm 3690 2 relationship relationship NN cord-023095-4dannjjm 3690 3 between between IN cord-023095-4dannjjm 3690 4 CFUs cfus NN cord-023095-4dannjjm 3690 5 and and CC cord-023095-4dannjjm 3690 6 the the DT cord-023095-4dannjjm 3690 7 peak peak NN cord-023095-4dannjjm 3690 8 of of IN cord-023095-4dannjjm 3690 9 the the DT cord-023095-4dannjjm 3690 10 -(d -(d NN cord-023095-4dannjjm 3690 11 / / SYM cord-023095-4dannjjm 3690 12 dt dt NN cord-023095-4dannjjm 3690 13 ) ) -RRB- cord-023095-4dannjjm 3690 14 fluorescence fluorescence NN cord-023095-4dannjjm 3690 15 of of IN cord-023095-4dannjjm 3690 16 the the DT cord-023095-4dannjjm 3690 17 melting melting NN cord-023095-4dannjjm 3690 18 curve curve NN cord-023095-4dannjjm 3690 19 was be VBD cord-023095-4dannjjm 3690 20 R2 R2 NNP cord-023095-4dannjjm 3690 21 5 5 CD cord-023095-4dannjjm 3690 22 0.988 0.988 CD cord-023095-4dannjjm 3690 23 . . . cord-023095-4dannjjm 3691 1 These these DT cord-023095-4dannjjm 3691 2 results result NNS cord-023095-4dannjjm 3691 3 conclude conclude VBP cord-023095-4dannjjm 3691 4 that that IN cord-023095-4dannjjm 3691 5 the the DT cord-023095-4dannjjm 3691 6 assay assay NN cord-023095-4dannjjm 3691 7 is be VBZ cord-023095-4dannjjm 3691 8 capable capable JJ cord-023095-4dannjjm 3691 9 of of IN cord-023095-4dannjjm 3691 10 detecting detect VBG cord-023095-4dannjjm 3691 11 not not RB cord-023095-4dannjjm 3691 12 only only RB cord-023095-4dannjjm 3691 13 the the DT cord-023095-4dannjjm 3691 14 presence presence NN cord-023095-4dannjjm 3691 15 of of IN cord-023095-4dannjjm 3691 16 Escherichia Escherichia NNP cord-023095-4dannjjm 3691 17 coli coli NNS cord-023095-4dannjjm 3691 18 in in IN cord-023095-4dannjjm 3691 19 clinical clinical JJ cord-023095-4dannjjm 3691 20 samples sample NNS cord-023095-4dannjjm 3691 21 , , , cord-023095-4dannjjm 3691 22 but but CC cord-023095-4dannjjm 3691 23 also also RB cord-023095-4dannjjm 3691 24 detecting detect VBG cord-023095-4dannjjm 3691 25 severity severity NN cord-023095-4dannjjm 3691 26 of of IN cord-023095-4dannjjm 3691 27 fluroquinolone fluroquinolone NN cord-023095-4dannjjm 3691 28 resistance resistance NN cord-023095-4dannjjm 3691 29 and and CC cord-023095-4dannjjm 3691 30 infection infection NN cord-023095-4dannjjm 3691 31 . . . cord-023095-4dannjjm 3692 1 The the DT cord-023095-4dannjjm 3692 2 fluoroquinolones fluoroquinolone NNS cord-023095-4dannjjm 3692 3 ( ( -LRB- cord-023095-4dannjjm 3692 4 FQs fq NNS cord-023095-4dannjjm 3692 5 ) ) -RRB- cord-023095-4dannjjm 3692 6 are be VBP cord-023095-4dannjjm 3692 7 a a DT cord-023095-4dannjjm 3692 8 key key JJ cord-023095-4dannjjm 3692 9 class class NN cord-023095-4dannjjm 3692 10 of of IN cord-023095-4dannjjm 3692 11 synthetic synthetic JJ cord-023095-4dannjjm 3692 12 antimicrobial antimicrobial JJ cord-023095-4dannjjm 3692 13 agents agent NNS cord-023095-4dannjjm 3692 14 with with IN cord-023095-4dannjjm 3692 15 an an DT cord-023095-4dannjjm 3692 16 established establish VBN cord-023095-4dannjjm 3692 17 history history NN cord-023095-4dannjjm 3692 18 in in IN cord-023095-4dannjjm 3692 19 both both DT cord-023095-4dannjjm 3692 20 humans human NNS cord-023095-4dannjjm 3692 21 and and CC cord-023095-4dannjjm 3692 22 companion companion NN cord-023095-4dannjjm 3692 23 animals animal NNS cord-023095-4dannjjm 3692 24 of of IN cord-023095-4dannjjm 3692 25 efficacy efficacy NN cord-023095-4dannjjm 3692 26 for for IN cord-023095-4dannjjm 3692 27 treatment treatment NN cord-023095-4dannjjm 3692 28 of of IN cord-023095-4dannjjm 3692 29 urinary urinary JJ cord-023095-4dannjjm 3692 30 tract tract NN cord-023095-4dannjjm 3692 31 infections infection NNS cord-023095-4dannjjm 3692 32 ( ( -LRB- cord-023095-4dannjjm 3692 33 UTIs uti NNS cord-023095-4dannjjm 3692 34 ) ) -RRB- cord-023095-4dannjjm 3692 35 caused cause VBN cord-023095-4dannjjm 3692 36 by by IN cord-023095-4dannjjm 3692 37 E. E. NNP cord-023095-4dannjjm 3692 38 coli coli NNS cord-023095-4dannjjm 3692 39 , , , cord-023095-4dannjjm 3692 40 and and CC cord-023095-4dannjjm 3692 41 fluoroquinolones fluoroquinolone NNS cord-023095-4dannjjm 3692 42 are be VBP cord-023095-4dannjjm 3692 43 common common JJ cord-023095-4dannjjm 3692 44 therapy therapy NN cord-023095-4dannjjm 3692 45 . . . cord-023095-4dannjjm 3693 1 Among among IN cord-023095-4dannjjm 3693 2 the the DT cord-023095-4dannjjm 3693 3 commonly commonly RB cord-023095-4dannjjm 3693 4 used use VBN cord-023095-4dannjjm 3693 5 FQs fq NNS cord-023095-4dannjjm 3693 6 in in IN cord-023095-4dannjjm 3693 7 dogs dog NNS cord-023095-4dannjjm 3693 8 and and CC cord-023095-4dannjjm 3693 9 cats cat NNS cord-023095-4dannjjm 3693 10 are be VBP cord-023095-4dannjjm 3693 11 the the DT cord-023095-4dannjjm 3693 12 2nd 2nd JJ cord-023095-4dannjjm 3693 13 generation generation NN cord-023095-4dannjjm 3693 14 drugs drug NNS cord-023095-4dannjjm 3693 15 , , , cord-023095-4dannjjm 3693 16 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 3693 17 , , , cord-023095-4dannjjm 3693 18 marbofloxacin marbofloxacin NNS cord-023095-4dannjjm 3693 19 , , , cord-023095-4dannjjm 3693 20 orbifloxacin orbifloxacin NNP cord-023095-4dannjjm 3693 21 ( ( -LRB- cord-023095-4dannjjm 3693 22 all all DT cord-023095-4dannjjm 3693 23 veterinary veterinary JJ cord-023095-4dannjjm 3693 24 approved approve VBN cord-023095-4dannjjm 3693 25 ) ) -RRB- cord-023095-4dannjjm 3693 26 and and CC cord-023095-4dannjjm 3693 27 the the DT cord-023095-4dannjjm 3693 28 human human JJ cord-023095-4dannjjm 3693 29 drug drug NN cord-023095-4dannjjm 3693 30 ciprofloxacin ciprofloxacin NNP cord-023095-4dannjjm 3693 31 ; ; : cord-023095-4dannjjm 3693 32 no no DT cord-023095-4dannjjm 3693 33 3rd 3rd JJ cord-023095-4dannjjm 3693 34 and and CC cord-023095-4dannjjm 3693 35 4th 4th JJ cord-023095-4dannjjm 3693 36 generation generation NN cord-023095-4dannjjm 3693 37 FQ FQ NNP cord-023095-4dannjjm 3693 38 is be VBZ cord-023095-4dannjjm 3693 39 routinely routinely RB cord-023095-4dannjjm 3693 40 used use VBN cord-023095-4dannjjm 3693 41 . . . cord-023095-4dannjjm 3694 1 The the DT cord-023095-4dannjjm 3694 2 purpose purpose NN cord-023095-4dannjjm 3694 3 of of IN cord-023095-4dannjjm 3694 4 this this DT cord-023095-4dannjjm 3694 5 study study NN cord-023095-4dannjjm 3694 6 was be VBD cord-023095-4dannjjm 3694 7 to to TO cord-023095-4dannjjm 3694 8 assess assess VB cord-023095-4dannjjm 3694 9 the the DT cord-023095-4dannjjm 3694 10 in in FW cord-023095-4dannjjm 3694 11 vitro vitro FW cord-023095-4dannjjm 3694 12 activity activity NN cord-023095-4dannjjm 3694 13 of of IN cord-023095-4dannjjm 3694 14 different different JJ cord-023095-4dannjjm 3694 15 generation generation NN cord-023095-4dannjjm 3694 16 FQs fq NNS cord-023095-4dannjjm 3694 17 toward toward IN cord-023095-4dannjjm 3694 18 E.coli e.coli JJ cord-023095-4dannjjm 3694 19 uropathogens uropathogen NNS cord-023095-4dannjjm 3694 20 whose whose WP$ cord-023095-4dannjjm 3694 21 phenotype phenotype NN cord-023095-4dannjjm 3694 22 ranges range VBZ cord-023095-4dannjjm 3694 23 from from IN cord-023095-4dannjjm 3694 24 no no DT cord-023095-4dannjjm 3694 25 resistance resistance NN cord-023095-4dannjjm 3694 26 to to IN cord-023095-4dannjjm 3694 27 multidrug multidrug NN cord-023095-4dannjjm 3694 28 resistance resistance NN cord-023095-4dannjjm 3694 29 . . . cord-023095-4dannjjm 3695 1 A a DT cord-023095-4dannjjm 3695 2 total total JJ cord-023095-4dannjjm 3695 3 number number NN cord-023095-4dannjjm 3695 4 of of IN cord-023095-4dannjjm 3695 5 51 51 CD cord-023095-4dannjjm 3695 6 canine canine JJ cord-023095-4dannjjm 3695 7 uropathogenic uropathogenic JJ cord-023095-4dannjjm 3695 8 canine canine JJ cord-023095-4dannjjm 3695 9 or or CC cord-023095-4dannjjm 3695 10 feline feline JJ cord-023095-4dannjjm 3695 11 E.coli e.coli NN cord-023095-4dannjjm 3695 12 isolates isolate NNS cord-023095-4dannjjm 3695 13 had have VBD cord-023095-4dannjjm 3695 14 been be VBN cord-023095-4dannjjm 3695 15 subjected subject VBN cord-023095-4dannjjm 3695 16 to to IN cord-023095-4dannjjm 3695 17 susceptibility susceptibility NN cord-023095-4dannjjm 3695 18 testing testing NN cord-023095-4dannjjm 3695 19 to to IN cord-023095-4dannjjm 3695 20 6 6 CD cord-023095-4dannjjm 3695 21 drugs drug NNS cord-023095-4dannjjm 3695 22 classes class NNS cord-023095-4dannjjm 3695 23 ( ( -LRB- cord-023095-4dannjjm 3695 24 15 15 CD cord-023095-4dannjjm 3695 25 drugs drug NNS cord-023095-4dannjjm 3695 26 ) ) -RRB- cord-023095-4dannjjm 3695 27 and and CC cord-023095-4dannjjm 3695 28 phenotyped phenotype VBN cord-023095-4dannjjm 3695 29 as as IN cord-023095-4dannjjm 3695 30 to to IN cord-023095-4dannjjm 3695 31 resistance resistance NN cord-023095-4dannjjm 3695 32 : : : cord-023095-4dannjjm 3695 33 none none NN cord-023095-4dannjjm 3695 34 ( ( -LRB- cord-023095-4dannjjm 3695 35 NDR NDR NNP cord-023095-4dannjjm 3695 36 , , , cord-023095-4dannjjm 3695 37 n n NN cord-023095-4dannjjm 3695 38 5 5 CD cord-023095-4dannjjm 3695 39 12 12 CD cord-023095-4dannjjm 3695 40 ) ) -RRB- cord-023095-4dannjjm 3695 41 , , , cord-023095-4dannjjm 3695 42 single single JJ cord-023095-4dannjjm 3695 43 ( ( -LRB- cord-023095-4dannjjm 3695 44 SDR SDR NNP cord-023095-4dannjjm 3695 45 , , , cord-023095-4dannjjm 3695 46 n n NN cord-023095-4dannjjm 3695 47 5 5 CD cord-023095-4dannjjm 3695 48 15 15 CD cord-023095-4dannjjm 3695 49 ) ) -RRB- cord-023095-4dannjjm 3695 50 , , , cord-023095-4dannjjm 3695 51 or or CC cord-023095-4dannjjm 3695 52 multiple multiple NN cord-023095-4dannjjm 3695 53 , , , cord-023095-4dannjjm 3695 54 MDR MDR NNP cord-023095-4dannjjm 3695 55 ( ( -LRB- cord-023095-4dannjjm 3695 56 resistance resistance NN cord-023095-4dannjjm 3695 57 to to IN cord-023095-4dannjjm 3695 58 2 2 CD cord-023095-4dannjjm 3695 59 - - SYM cord-023095-4dannjjm 3695 60 6 6 CD cord-023095-4dannjjm 3695 61 drug drug NN cord-023095-4dannjjm 3695 62 classes class NNS cord-023095-4dannjjm 3695 63 ; ; : cord-023095-4dannjjm 3695 64 n n NN cord-023095-4dannjjm 3695 65 5 5 CD cord-023095-4dannjjm 3695 66 24 24 CD cord-023095-4dannjjm 3695 67 ) ) -RRB- cord-023095-4dannjjm 3695 68 . . . cord-023095-4dannjjm 3696 1 MDR MDR NNP cord-023095-4dannjjm 3696 2 included include VBD cord-023095-4dannjjm 3696 3 isolates isolate NNS cord-023095-4dannjjm 3696 4 susceptible susceptible JJ cord-023095-4dannjjm 3696 5 ( ( -LRB- cord-023095-4dannjjm 3696 6 ENR ENR NNP cord-023095-4dannjjm 3696 7 S S NNP cord-023095-4dannjjm 3696 8 -MDR -MDR -RRB- cord-023095-4dannjjm 3696 9 , , , cord-023095-4dannjjm 3696 10 n n NN cord-023095-4dannjjm 3696 11 5 5 CD cord-023095-4dannjjm 3696 12 12 12 CD cord-023095-4dannjjm 3696 13 ) ) -RRB- cord-023095-4dannjjm 3696 14 or or CC cord-023095-4dannjjm 3696 15 resistant resistant JJ cord-023095-4dannjjm 3696 16 ( ( -LRB- cord-023095-4dannjjm 3696 17 ENR ENR NNP cord-023095-4dannjjm 3696 18 R R NNP cord-023095-4dannjjm 3696 19 -MDR -MDR -RRB- cord-023095-4dannjjm 3696 20 ) ) -RRB- cord-023095-4dannjjm 3696 21 to to IN cord-023095-4dannjjm 3696 22 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 3696 23 . . . cord-023095-4dannjjm 3697 1 The the DT cord-023095-4dannjjm 3697 2 minimum minimum JJ cord-023095-4dannjjm 3697 3 inhibition inhibition NN cord-023095-4dannjjm 3697 4 concentrations concentration NNS cord-023095-4dannjjm 3697 5 ( ( -LRB- cord-023095-4dannjjm 3697 6 MICs mic NNS cord-023095-4dannjjm 3697 7 ) ) -RRB- cord-023095-4dannjjm 3697 8 for for IN cord-023095-4dannjjm 3697 9 11 11 CD cord-023095-4dannjjm 3697 10 quinolones quinolone NNS cord-023095-4dannjjm 3697 11 ( ( -LRB- cord-023095-4dannjjm 3697 12 1 1 CD cord-023095-4dannjjm 3697 13 - - HYPH cord-023095-4dannjjm 3697 14 1st 1st JJ cord-023095-4dannjjm 3697 15 generation generation NN cord-023095-4dannjjm 3697 16 , , , cord-023095-4dannjjm 3697 17 3 3 CD cord-023095-4dannjjm 3697 18 - - HYPH cord-023095-4dannjjm 3697 19 2nd 2nd JJ cord-023095-4dannjjm 3697 20 generation generation NN cord-023095-4dannjjm 3697 21 , , , cord-023095-4dannjjm 3697 22 4 4 CD cord-023095-4dannjjm 3697 23 - - HYPH cord-023095-4dannjjm 3697 24 3rd 3rd JJ cord-023095-4dannjjm 3697 25 generation generation NN cord-023095-4dannjjm 3697 26 and and CC cord-023095-4dannjjm 3697 27 3 3 CD cord-023095-4dannjjm 3697 28 - - HYPH cord-023095-4dannjjm 3697 29 4th 4th JJ cord-023095-4dannjjm 3697 30 generation generation NN cord-023095-4dannjjm 3697 31 ) ) -RRB- cord-023095-4dannjjm 3697 32 were be VBD cord-023095-4dannjjm 3697 33 determined determine VBN cord-023095-4dannjjm 3697 34 for for IN cord-023095-4dannjjm 3697 35 these these DT cord-023095-4dannjjm 3697 36 isolates isolate NNS cord-023095-4dannjjm 3697 37 using use VBG cord-023095-4dannjjm 3697 38 broth broth NN cord-023095-4dannjjm 3697 39 microdilution microdilution NN cord-023095-4dannjjm 3697 40 methods method NNS cord-023095-4dannjjm 3697 41 according accord VBG cord-023095-4dannjjm 3697 42 to to IN cord-023095-4dannjjm 3697 43 CLSI CLSI NNP cord-023095-4dannjjm 3697 44 guidelines guideline NNS cord-023095-4dannjjm 3697 45 ( ( -LRB- cord-023095-4dannjjm 3697 46 E. E. NNP cord-023095-4dannjjm 3697 47 coli coli VBZ cord-023095-4dannjjm 3697 48 ATCC ATCC NNP cord-023095-4dannjjm 3697 49 s s POS cord-023095-4dannjjm 3697 50 25922 25922 CD cord-023095-4dannjjm 3697 51 served serve VBD cord-023095-4dannjjm 3697 52 as as IN cord-023095-4dannjjm 3697 53 a a DT cord-023095-4dannjjm 3697 54 negative negative JJ cord-023095-4dannjjm 3697 55 control control NN cord-023095-4dannjjm 3697 56 ) ) -RRB- cord-023095-4dannjjm 3697 57 . . . cord-023095-4dannjjm 3698 1 MIC mic NN cord-023095-4dannjjm 3698 2 statistics statistic NNS cord-023095-4dannjjm 3698 3 were be VBD cord-023095-4dannjjm 3698 4 generated generate VBN cord-023095-4dannjjm 3698 5 for for IN cord-023095-4dannjjm 3698 6 each each DT cord-023095-4dannjjm 3698 7 drug drug NN cord-023095-4dannjjm 3698 8 among among IN cord-023095-4dannjjm 3698 9 phenotypes phenotype NNS cord-023095-4dannjjm 3698 10 . . . cord-023095-4dannjjm 3699 1 The the DT cord-023095-4dannjjm 3699 2 results result NNS cord-023095-4dannjjm 3699 3 showed show VBD cord-023095-4dannjjm 3699 4 that that IN cord-023095-4dannjjm 3699 5 companion companion NN cord-023095-4dannjjm 3699 6 animal animal NN cord-023095-4dannjjm 3699 7 E. E. NNP cord-023095-4dannjjm 3699 8 coli coli NNS cord-023095-4dannjjm 3699 9 expressing express VBG cord-023095-4dannjjm 3699 10 NDR NDR NNP cord-023095-4dannjjm 3699 11 or or CC cord-023095-4dannjjm 3699 12 SDR SDR NNP cord-023095-4dannjjm 3699 13 are be VBP cord-023095-4dannjjm 3699 14 largely largely RB cord-023095-4dannjjm 3699 15 susceptible susceptible JJ cord-023095-4dannjjm 3699 16 to to IN cord-023095-4dannjjm 3699 17 2nd 2nd JJ cord-023095-4dannjjm 3699 18 to to IN cord-023095-4dannjjm 3699 19 4th 4th JJ cord-023095-4dannjjm 3699 20 generation generation NN cord-023095-4dannjjm 3699 21 FQs fq NNS cord-023095-4dannjjm 3699 22 . . . cord-023095-4dannjjm 3700 1 However however RB cord-023095-4dannjjm 3700 2 , , , cord-023095-4dannjjm 3700 3 isolates isolate NNS cord-023095-4dannjjm 3700 4 expressing express VBG cord-023095-4dannjjm 3700 5 resistance resistance NN cord-023095-4dannjjm 3700 6 to to IN cord-023095-4dannjjm 3700 7 1st 1st JJ cord-023095-4dannjjm 3700 8 or or CC cord-023095-4dannjjm 3700 9 2nd 2nd JJ cord-023095-4dannjjm 3700 10 generation generation NN cord-023095-4dannjjm 3700 11 quinolone quinolone NNP cord-023095-4dannjjm 3700 12 also also RB cord-023095-4dannjjm 3700 13 express express VBP cord-023095-4dannjjm 3700 14 high high JJ cord-023095-4dannjjm 3700 15 level level NN cord-023095-4dannjjm 3700 16 resistance resistance NN cord-023095-4dannjjm 3700 17 based base VBN cord-023095-4dannjjm 3700 18 on on IN cord-023095-4dannjjm 3700 19 the the DT cord-023095-4dannjjm 3700 20 MIC MIC NNP cord-023095-4dannjjm 3700 21 90 90 CD cord-023095-4dannjjm 3700 22 to to IN cord-023095-4dannjjm 3700 23 3rd 3rd JJ cord-023095-4dannjjm 3700 24 and and CC cord-023095-4dannjjm 3700 25 4th 4th JJ cord-023095-4dannjjm 3700 26 generation generation NN cord-023095-4dannjjm 3700 27 FQs fq NNS cord-023095-4dannjjm 3700 28 . . . cord-023095-4dannjjm 3701 1 The the DT cord-023095-4dannjjm 3701 2 overall overall JJ cord-023095-4dannjjm 3701 3 potency potency NN cord-023095-4dannjjm 3701 4 ( ( -LRB- cord-023095-4dannjjm 3701 5 MIC MIC NNP cord-023095-4dannjjm 3701 6 ) ) -RRB- cord-023095-4dannjjm 3701 7 for for IN cord-023095-4dannjjm 3701 8 the the DT cord-023095-4dannjjm 3701 9 11 11 CD cord-023095-4dannjjm 3701 10 drugs drug NNS cord-023095-4dannjjm 3701 11 for for IN cord-023095-4dannjjm 3701 12 isolates isolate NNS cord-023095-4dannjjm 3701 13 not not RB cord-023095-4dannjjm 3701 14 expressing express VBG cord-023095-4dannjjm 3701 15 ENR ENR NNP cord-023095-4dannjjm 3701 16 resistance resistance NN cord-023095-4dannjjm 3701 17 ( ( -LRB- cord-023095-4dannjjm 3701 18 that that RB cord-023095-4dannjjm 3701 19 is is RB cord-023095-4dannjjm 3701 20 , , , cord-023095-4dannjjm 3701 21 NDR NDR NNP cord-023095-4dannjjm 3701 22 , , , cord-023095-4dannjjm 3701 23 SDR SDR NNP cord-023095-4dannjjm 3701 24 and and CC cord-023095-4dannjjm 3701 25 ENR ENR NNP cord-023095-4dannjjm 3701 26 S S NNP cord-023095-4dannjjm 3701 27 -MDR -MDR -RRB- cord-023095-4dannjjm 3701 28 ) ) -RRB- cord-023095-4dannjjm 3701 29 is be VBZ cord-023095-4dannjjm 3701 30 GAT GAT NNP cord-023095-4dannjjm 3701 31 Canine canine JJ cord-023095-4dannjjm 3701 32 leproid leproid NN cord-023095-4dannjjm 3701 33 granuloma granuloma NN cord-023095-4dannjjm 3701 34 ( ( -LRB- cord-023095-4dannjjm 3701 35 CLG CLG NNP cord-023095-4dannjjm 3701 36 ) ) -RRB- cord-023095-4dannjjm 3701 37 was be VBD cord-023095-4dannjjm 3701 38 first first RB cord-023095-4dannjjm 3701 39 reported report VBN cord-023095-4dannjjm 3701 40 in in IN cord-023095-4dannjjm 3701 41 Brazil Brazil NNP cord-023095-4dannjjm 3701 42 in in IN cord-023095-4dannjjm 3701 43 1990 1990 CD cord-023095-4dannjjm 3701 44 . . . cord-023095-4dannjjm 3702 1 Over over IN cord-023095-4dannjjm 3702 2 the the DT cord-023095-4dannjjm 3702 3 past past JJ cord-023095-4dannjjm 3702 4 20 20 CD cord-023095-4dannjjm 3702 5 years year NNS cord-023095-4dannjjm 3702 6 , , , cord-023095-4dannjjm 3702 7 37 37 CD cord-023095-4dannjjm 3702 8 cases case NNS cord-023095-4dannjjm 3702 9 of of IN cord-023095-4dannjjm 3702 10 CLG CLG NNP cord-023095-4dannjjm 3702 11 were be VBD cord-023095-4dannjjm 3702 12 diagnosed diagnose VBN cord-023095-4dannjjm 3702 13 in in IN cord-023095-4dannjjm 3702 14 Sa˜o Sa˜o NNP cord-023095-4dannjjm 3702 15 Paulo Paulo NNP cord-023095-4dannjjm 3702 16 , , , cord-023095-4dannjjm 3702 17 Brazil Brazil NNP cord-023095-4dannjjm 3702 18 , , , cord-023095-4dannjjm 3702 19 and and CC cord-023095-4dannjjm 3702 20 clinical clinical JJ cord-023095-4dannjjm 3702 21 and and CC cord-023095-4dannjjm 3702 22 epidemiological epidemiological JJ cord-023095-4dannjjm 3702 23 findings finding NNS cord-023095-4dannjjm 3702 24 were be VBD cord-023095-4dannjjm 3702 25 similar similar JJ cord-023095-4dannjjm 3702 26 to to IN cord-023095-4dannjjm 3702 27 those those DT cord-023095-4dannjjm 3702 28 reported report VBN cord-023095-4dannjjm 3702 29 in in IN cord-023095-4dannjjm 3702 30 Australia Australia NNP cord-023095-4dannjjm 3702 31 . . . cord-023095-4dannjjm 3703 1 All all DT cord-023095-4dannjjm 3703 2 dogs dog NNS cord-023095-4dannjjm 3703 3 presented present VBN cord-023095-4dannjjm 3703 4 with with IN cord-023095-4dannjjm 3703 5 one one CD cord-023095-4dannjjm 3703 6 or or CC cord-023095-4dannjjm 3703 7 more more JJR cord-023095-4dannjjm 3703 8 , , , cord-023095-4dannjjm 3703 9 uni uni NN cord-023095-4dannjjm 3703 10 or or CC cord-023095-4dannjjm 3703 11 bilateral bilateral JJ cord-023095-4dannjjm 3703 12 , , , cord-023095-4dannjjm 3703 13 ulcerated ulcerated JJ cord-023095-4dannjjm 3703 14 or or CC cord-023095-4dannjjm 3703 15 not not RB cord-023095-4dannjjm 3703 16 , , , cord-023095-4dannjjm 3703 17 papular papular JJ cord-023095-4dannjjm 3703 18 , , , cord-023095-4dannjjm 3703 19 nodular nodular JJ cord-023095-4dannjjm 3703 20 or or CC cord-023095-4dannjjm 3703 21 tumoral tumoral JJ cord-023095-4dannjjm 3703 22 lesions lesion NNS cord-023095-4dannjjm 3703 23 , , , cord-023095-4dannjjm 3703 24 mainly mainly RB cord-023095-4dannjjm 3703 25 observed observe VBD cord-023095-4dannjjm 3703 26 in in IN cord-023095-4dannjjm 3703 27 the the DT cord-023095-4dannjjm 3703 28 dorsal dorsal JJ cord-023095-4dannjjm 3703 29 surface surface NN cord-023095-4dannjjm 3703 30 of of IN cord-023095-4dannjjm 3703 31 the the DT cord-023095-4dannjjm 3703 32 ear ear NN cord-023095-4dannjjm 3703 33 , , , cord-023095-4dannjjm 3703 34 site site NN cord-023095-4dannjjm 3703 35 usually usually RB cord-023095-4dannjjm 3703 36 more more RBR cord-023095-4dannjjm 3703 37 affected affected JJ cord-023095-4dannjjm 3703 38 . . . cord-023095-4dannjjm 3704 1 In in IN cord-023095-4dannjjm 3704 2 general general JJ cord-023095-4dannjjm 3704 3 , , , cord-023095-4dannjjm 3704 4 the the DT cord-023095-4dannjjm 3704 5 lesions lesion NNS cord-023095-4dannjjm 3704 6 are be VBP cord-023095-4dannjjm 3704 7 painless painless JJ cord-023095-4dannjjm 3704 8 and and CC cord-023095-4dannjjm 3704 9 confined confine VBN cord-023095-4dannjjm 3704 10 to to IN cord-023095-4dannjjm 3704 11 the the DT cord-023095-4dannjjm 3704 12 subcutis subcutis NN cord-023095-4dannjjm 3704 13 and and CC cord-023095-4dannjjm 3704 14 skin skin NN cord-023095-4dannjjm 3704 15 , , , cord-023095-4dannjjm 3704 16 and and CC cord-023095-4dannjjm 3704 17 it -PRON- PRP cord-023095-4dannjjm 3704 18 does do VBZ cord-023095-4dannjjm 3704 19 not not RB cord-023095-4dannjjm 3704 20 involve involve VB cord-023095-4dannjjm 3704 21 regional regional JJ cord-023095-4dannjjm 3704 22 lymph lymph NN cord-023095-4dannjjm 3704 23 nodes node NNS cord-023095-4dannjjm 3704 24 , , , cord-023095-4dannjjm 3704 25 nerves nerve NNS cord-023095-4dannjjm 3704 26 or or CC cord-023095-4dannjjm 3704 27 internal internal JJ cord-023095-4dannjjm 3704 28 organs organ NNS cord-023095-4dannjjm 3704 29 , , , cord-023095-4dannjjm 3704 30 and and CC cord-023095-4dannjjm 3704 31 systemic systemic JJ cord-023095-4dannjjm 3704 32 clinical clinical JJ cord-023095-4dannjjm 3704 33 signs sign NNS cord-023095-4dannjjm 3704 34 frequently frequently RB cord-023095-4dannjjm 3704 35 are be VBP cord-023095-4dannjjm 3704 36 absent absent JJ cord-023095-4dannjjm 3704 37 . . . cord-023095-4dannjjm 3705 1 Short short JJ cord-023095-4dannjjm 3705 2 - - HYPH cord-023095-4dannjjm 3705 3 coated coated JJ cord-023095-4dannjjm 3705 4 breeds breed NNS cord-023095-4dannjjm 3705 5 show show VBP cord-023095-4dannjjm 3705 6 a a DT cord-023095-4dannjjm 3705 7 marked marked JJ cord-023095-4dannjjm 3705 8 predisposition predisposition NN cord-023095-4dannjjm 3705 9 for for IN cord-023095-4dannjjm 3705 10 this this DT cord-023095-4dannjjm 3705 11 disease disease NN cord-023095-4dannjjm 3705 12 . . . cord-023095-4dannjjm 3706 1 The the DT cord-023095-4dannjjm 3706 2 definitive definitive JJ cord-023095-4dannjjm 3706 3 diagnosis diagnosis NN cord-023095-4dannjjm 3706 4 of of IN cord-023095-4dannjjm 3706 5 CLG CLG NNP cord-023095-4dannjjm 3706 6 was be VBD cord-023095-4dannjjm 3706 7 obtained obtain VBN cord-023095-4dannjjm 3706 8 by by IN cord-023095-4dannjjm 3706 9 histological histological JJ cord-023095-4dannjjm 3706 10 examination examination NN cord-023095-4dannjjm 3706 11 of of IN cord-023095-4dannjjm 3706 12 skin skin NN cord-023095-4dannjjm 3706 13 biopsies biopsy NNS cord-023095-4dannjjm 3706 14 that that WDT cord-023095-4dannjjm 3706 15 were be VBD cord-023095-4dannjjm 3706 16 stained stain VBN cord-023095-4dannjjm 3706 17 with with IN cord-023095-4dannjjm 3706 18 acid acid NN cord-023095-4dannjjm 3706 19 fast fast RB cord-023095-4dannjjm 3707 1 ( ( -LRB- cord-023095-4dannjjm 3707 2 Ziehl Ziehl NNP cord-023095-4dannjjm 3707 3 - - HYPH cord-023095-4dannjjm 3707 4 Neelsen Neelsen NNP cord-023095-4dannjjm 3707 5 ) ) -RRB- cord-023095-4dannjjm 3707 6 and and CC cord-023095-4dannjjm 3707 7 DiffQuik DiffQuik NNP cord-023095-4dannjjm 3707 8 s s NNP cord-023095-4dannjjm 3707 9 . . . cord-023095-4dannjjm 3708 1 Thirty thirty CD cord-023095-4dannjjm 3708 2 one one CD cord-023095-4dannjjm 3708 3 ( ( -LRB- cord-023095-4dannjjm 3708 4 83.7 83.7 CD cord-023095-4dannjjm 3708 5 % % NN cord-023095-4dannjjm 3708 6 ) ) -RRB- cord-023095-4dannjjm 3708 7 of of IN cord-023095-4dannjjm 3708 8 the the DT cord-023095-4dannjjm 3708 9 dogs dog NNS cord-023095-4dannjjm 3708 10 were be VBD cord-023095-4dannjjm 3708 11 purebred purebred JJ cord-023095-4dannjjm 3708 12 ; ; : cord-023095-4dannjjm 3708 13 in in IN cord-023095-4dannjjm 3708 14 this this DT cord-023095-4dannjjm 3708 15 study study NN cord-023095-4dannjjm 3708 16 the the DT cord-023095-4dannjjm 3708 17 breed breed NN cord-023095-4dannjjm 3708 18 pattern pattern NN cord-023095-4dannjjm 3708 19 comprised comprise VBN cord-023095-4dannjjm 3708 20 19 19 CD cord-023095-4dannjjm 3708 21 ( ( -LRB- cord-023095-4dannjjm 3708 22 61.3 61.3 CD cord-023095-4dannjjm 3708 23 % % NN cord-023095-4dannjjm 3708 24 ) ) -RRB- cord-023095-4dannjjm 3708 25 Boxers Boxers NNPS cord-023095-4dannjjm 3708 26 , , , cord-023095-4dannjjm 3708 27 2 2 CD cord-023095-4dannjjm 3708 28 ( ( -LRB- cord-023095-4dannjjm 3708 29 6.5 6.5 CD cord-023095-4dannjjm 3708 30 % % NN cord-023095-4dannjjm 3708 31 ) ) -RRB- cord-023095-4dannjjm 3709 1 German german JJ cord-023095-4dannjjm 3709 2 Shepherd Shepherd NNP cord-023095-4dannjjm 3709 3 and and CC cord-023095-4dannjjm 3709 4 Labrador Labrador NNP cord-023095-4dannjjm 3709 5 Retriever Retriever NNP cord-023095-4dannjjm 3709 6 , , , cord-023095-4dannjjm 3709 7 1 1 CD cord-023095-4dannjjm 3709 8 ( ( -LRB- cord-023095-4dannjjm 3709 9 3.2 3.2 CD cord-023095-4dannjjm 3709 10 % % NN cord-023095-4dannjjm 3709 11 ) ) -RRB- cord-023095-4dannjjm 3710 1 Dobermann Dobermann NNP cord-023095-4dannjjm 3710 2 , , , cord-023095-4dannjjm 3710 3 1 1 CD cord-023095-4dannjjm 3710 4 ( ( -LRB- cord-023095-4dannjjm 3710 5 3.2 3.2 CD cord-023095-4dannjjm 3710 6 % % NN cord-023095-4dannjjm 3710 7 ) ) -RRB- cord-023095-4dannjjm 3711 1 Brazilian Brazilian NNP cord-023095-4dannjjm 3711 2 Terrier Terrier NNP cord-023095-4dannjjm 3711 3 , , , cord-023095-4dannjjm 3711 4 1 1 CD cord-023095-4dannjjm 3711 5 ( ( -LRB- cord-023095-4dannjjm 3711 6 3.2 3.2 CD cord-023095-4dannjjm 3711 7 % % NN cord-023095-4dannjjm 3711 8 ) ) -RRB- cord-023095-4dannjjm 3712 1 Golden Golden NNP cord-023095-4dannjjm 3712 2 Retriever Retriever NNP cord-023095-4dannjjm 3712 3 , , , cord-023095-4dannjjm 3712 4 1 1 CD cord-023095-4dannjjm 3712 5 ( ( -LRB- cord-023095-4dannjjm 3712 6 3.2 3.2 CD cord-023095-4dannjjm 3712 7 % % NN cord-023095-4dannjjm 3712 8 ) ) -RRB- cord-023095-4dannjjm 3712 9 Bulldog Bulldog NNP cord-023095-4dannjjm 3712 10 , , , cord-023095-4dannjjm 3712 11 1 1 CD cord-023095-4dannjjm 3712 12 ( ( -LRB- cord-023095-4dannjjm 3712 13 2.8 2.8 CD cord-023095-4dannjjm 3712 14 % % NN cord-023095-4dannjjm 3712 15 ) ) -RRB- cord-023095-4dannjjm 3712 16 American american JJ cord-023095-4dannjjm 3712 17 Pitbull Pitbull NNP cord-023095-4dannjjm 3712 18 , , , cord-023095-4dannjjm 3712 19 1 1 CD cord-023095-4dannjjm 3712 20 ( ( -LRB- cord-023095-4dannjjm 3712 21 3.2 3.2 CD cord-023095-4dannjjm 3712 22 % % NN cord-023095-4dannjjm 3712 23 ) ) -RRB- cord-023095-4dannjjm 3712 24 Mastiff Mastiff NNP cord-023095-4dannjjm 3712 25 , , , cord-023095-4dannjjm 3712 26 1 1 CD cord-023095-4dannjjm 3712 27 ( ( -LRB- cord-023095-4dannjjm 3712 28 3.2 3.2 CD cord-023095-4dannjjm 3712 29 % % NN cord-023095-4dannjjm 3712 30 ) ) -RRB- cord-023095-4dannjjm 3713 1 Fila Fila NNP cord-023095-4dannjjm 3713 2 Brasileiro Brasileiro NNP cord-023095-4dannjjm 3713 3 and and CC cord-023095-4dannjjm 3713 4 1 1 CD cord-023095-4dannjjm 3713 5 ( ( -LRB- cord-023095-4dannjjm 3713 6 3.2 3.2 CD cord-023095-4dannjjm 3713 7 % % NN cord-023095-4dannjjm 3713 8 ) ) -RRB- cord-023095-4dannjjm 3714 1 Cocker Cocker NNP cord-023095-4dannjjm 3714 2 spaniel spaniel NN cord-023095-4dannjjm 3714 3 , , , cord-023095-4dannjjm 3714 4 6 6 CD cord-023095-4dannjjm 3714 5 ( ( -LRB- cord-023095-4dannjjm 3714 6 16.3 16.3 CD cord-023095-4dannjjm 3714 7 % % NN cord-023095-4dannjjm 3714 8 ) ) -RRB- cord-023095-4dannjjm 3714 9 were be VBD cord-023095-4dannjjm 3714 10 of of IN cord-023095-4dannjjm 3714 11 unknown unknown JJ cord-023095-4dannjjm 3714 12 breed breed NN cord-023095-4dannjjm 3714 13 . . . cord-023095-4dannjjm 3715 1 Nineteen nineteen CD cord-023095-4dannjjm 3715 2 ( ( -LRB- cord-023095-4dannjjm 3715 3 51.4 51.4 CD cord-023095-4dannjjm 3715 4 % % NN cord-023095-4dannjjm 3715 5 ) ) -RRB- cord-023095-4dannjjm 3715 6 of of IN cord-023095-4dannjjm 3715 7 the the DT cord-023095-4dannjjm 3715 8 thirty thirty CD cord-023095-4dannjjm 3715 9 seven seven CD cord-023095-4dannjjm 3715 10 dogs dog NNS cord-023095-4dannjjm 3715 11 were be VBD cord-023095-4dannjjm 3715 12 males male NNS cord-023095-4dannjjm 3715 13 . . . cord-023095-4dannjjm 3716 1 Twenty twenty CD cord-023095-4dannjjm 3716 2 ( ( -LRB- cord-023095-4dannjjm 3716 3 54.1 54.1 CD cord-023095-4dannjjm 3716 4 % % NN cord-023095-4dannjjm 3716 5 ) ) -RRB- cord-023095-4dannjjm 3716 6 dogs dog NNS cord-023095-4dannjjm 3716 7 were be VBD cord-023095-4dannjjm 3716 8 4 4 CD cord-023095-4dannjjm 3716 9 - - SYM cord-023095-4dannjjm 3716 10 6 6 CD cord-023095-4dannjjm 3716 11 years year NNS cord-023095-4dannjjm 3716 12 old old JJ cord-023095-4dannjjm 3716 13 . . . cord-023095-4dannjjm 3717 1 In in IN cord-023095-4dannjjm 3717 2 most most JJS cord-023095-4dannjjm 3717 3 cases case NNS cord-023095-4dannjjm 3717 4 , , , cord-023095-4dannjjm 3717 5 dogs dog NNS cord-023095-4dannjjm 3717 6 presented present VBN cord-023095-4dannjjm 3717 7 with with IN cord-023095-4dannjjm 3717 8 unilateral unilateral JJ cord-023095-4dannjjm 3717 9 or or CC cord-023095-4dannjjm 3717 10 bilateral bilateral JJ cord-023095-4dannjjm 3717 11 ear ear NN cord-023095-4dannjjm 3717 12 lesions lesion NNS cord-023095-4dannjjm 3717 13 , , , cord-023095-4dannjjm 3717 14 but but CC cord-023095-4dannjjm 3717 15 rarely rarely RB cord-023095-4dannjjm 3717 16 thoracic thoracic JJ cord-023095-4dannjjm 3717 17 , , , cord-023095-4dannjjm 3717 18 foot foot NN cord-023095-4dannjjm 3717 19 and and CC cord-023095-4dannjjm 3717 20 caudal caudal JJ cord-023095-4dannjjm 3717 21 lesions lesion NNS cord-023095-4dannjjm 3717 22 . . . cord-023095-4dannjjm 3718 1 The the DT cord-023095-4dannjjm 3718 2 animals animal NNS cord-023095-4dannjjm 3718 3 were be VBD cord-023095-4dannjjm 3718 4 successfully successfully RB cord-023095-4dannjjm 3718 5 treated treat VBN cord-023095-4dannjjm 3718 6 by by IN cord-023095-4dannjjm 3718 7 use use NN cord-023095-4dannjjm 3718 8 of of IN cord-023095-4dannjjm 3718 9 rifampicin rifampicin NNS cord-023095-4dannjjm 3718 10 orally orally RB cord-023095-4dannjjm 3718 11 ( ( -LRB- cord-023095-4dannjjm 3718 12 ' ' `` cord-023095-4dannjjm 3718 13 ' ' '' cord-023095-4dannjjm 3718 14 the the DT cord-023095-4dannjjm 3718 15 brazilian brazilian JJ cord-023095-4dannjjm 3718 16 protocol protocol NN cord-023095-4dannjjm 3718 17 ' ' '' cord-023095-4dannjjm 3718 18 ' ' '' cord-023095-4dannjjm 3718 19 ) ) -RRB- cord-023095-4dannjjm 3718 20 or or CC cord-023095-4dannjjm 3718 21 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 3718 22 orally orally RB cord-023095-4dannjjm 3718 23 and and CC cord-023095-4dannjjm 3718 24 topical topical JJ cord-023095-4dannjjm 3718 25 rifamicin rifamicin NNS cord-023095-4dannjjm 3718 26 . . . cord-023095-4dannjjm 3719 1 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3719 2 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3719 3 is be VBZ cord-023095-4dannjjm 3719 4 being be VBG cord-023095-4dannjjm 3719 5 recognized recognize VBN cord-023095-4dannjjm 3719 6 more more RBR cord-023095-4dannjjm 3719 7 frequently frequently RB cord-023095-4dannjjm 3719 8 in in IN cord-023095-4dannjjm 3719 9 dogs dog NNS cord-023095-4dannjjm 3719 10 in in IN cord-023095-4dannjjm 3719 11 endemic endemic JJ cord-023095-4dannjjm 3719 12 areas area NNS cord-023095-4dannjjm 3719 13 . . . cord-023095-4dannjjm 3720 1 Currently currently RB cord-023095-4dannjjm 3720 2 , , , cord-023095-4dannjjm 3720 3 most most RBS cord-023095-4dannjjm 3720 4 suspected suspect VBN cord-023095-4dannjjm 3720 5 cases case NNS cord-023095-4dannjjm 3720 6 are be VBP cord-023095-4dannjjm 3720 7 evaluated evaluate VBN cord-023095-4dannjjm 3720 8 for for IN cord-023095-4dannjjm 3720 9 A. a. JJ cord-023095-4dannjjm 3720 10 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3720 11 antibodies antibody NNS cord-023095-4dannjjm 3720 12 by by IN cord-023095-4dannjjm 3720 13 immunofluorescence immunofluorescence NN cord-023095-4dannjjm 3720 14 assay assay NN cord-023095-4dannjjm 3720 15 ( ( -LRB- cord-023095-4dannjjm 3720 16 IFA IFA NNP cord-023095-4dannjjm 3720 17 ) ) -RRB- cord-023095-4dannjjm 3720 18 or or CC cord-023095-4dannjjm 3720 19 ELISA ELISA NNP cord-023095-4dannjjm 3720 20 . . . cord-023095-4dannjjm 3721 1 Since since IN cord-023095-4dannjjm 3721 2 A. a. NN cord-023095-4dannjjm 3721 3 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3721 4 is be VBZ cord-023095-4dannjjm 3721 5 an an DT cord-023095-4dannjjm 3721 6 acute acute JJ cord-023095-4dannjjm 3721 7 disease disease NN cord-023095-4dannjjm 3721 8 , , , cord-023095-4dannjjm 3721 9 detection detection NN cord-023095-4dannjjm 3721 10 by by IN cord-023095-4dannjjm 3721 11 antibody antibody NN cord-023095-4dannjjm 3721 12 measurement measurement NN cord-023095-4dannjjm 3721 13 may may MD cord-023095-4dannjjm 3721 14 be be VB cord-023095-4dannjjm 3721 15 negative negative JJ cord-023095-4dannjjm 3721 16 on on IN cord-023095-4dannjjm 3721 17 initial initial JJ cord-023095-4dannjjm 3721 18 evaluation evaluation NN cord-023095-4dannjjm 3721 19 . . . cord-023095-4dannjjm 3722 1 It -PRON- PRP cord-023095-4dannjjm 3722 2 is be VBZ cord-023095-4dannjjm 3722 3 possible possible JJ cord-023095-4dannjjm 3722 4 that that IN cord-023095-4dannjjm 3722 5 A. a. NN cord-023095-4dannjjm 3722 6 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3722 7 DNA dna NN cord-023095-4dannjjm 3722 8 can can MD cord-023095-4dannjjm 3722 9 be be VB cord-023095-4dannjjm 3722 10 amplified amplify VBN cord-023095-4dannjjm 3722 11 from from IN cord-023095-4dannjjm 3722 12 blood blood NN cord-023095-4dannjjm 3722 13 or or CC cord-023095-4dannjjm 3722 14 synovial synovial JJ cord-023095-4dannjjm 3722 15 fluid fluid NN cord-023095-4dannjjm 3722 16 prior prior RB cord-023095-4dannjjm 3722 17 to to IN cord-023095-4dannjjm 3722 18 seroconversion seroconversion NN cord-023095-4dannjjm 3722 19 . . . cord-023095-4dannjjm 3723 1 Wild wild NN cord-023095-4dannjjm 3723 2 caught catch VBD cord-023095-4dannjjm 3723 3 Ixodes Ixodes NNP cord-023095-4dannjjm 3723 4 scapularis scapularis JJ cord-023095-4dannjjm 3723 5 adult adult NN cord-023095-4dannjjm 3723 6 ticks tick NNS cord-023095-4dannjjm 3723 7 from from IN cord-023095-4dannjjm 3723 8 Rhode Rhode NNP cord-023095-4dannjjm 3723 9 Island Island NNP cord-023095-4dannjjm 3723 10 were be VBD cord-023095-4dannjjm 3723 11 allowed allow VBN cord-023095-4dannjjm 3723 12 to to TO cord-023095-4dannjjm 3723 13 feed feed VB cord-023095-4dannjjm 3723 14 on on IN cord-023095-4dannjjm 3723 15 18 18 CD cord-023095-4dannjjm 3723 16 young young JJ cord-023095-4dannjjm 3723 17 adult adult NN cord-023095-4dannjjm 3723 18 ( ( -LRB- cord-023095-4dannjjm 3723 19 2 2 CD cord-023095-4dannjjm 3723 20 - - SYM cord-023095-4dannjjm 3723 21 3 3 CD cord-023095-4dannjjm 3723 22 years year NNS cord-023095-4dannjjm 3723 23 ) ) -RRB- cord-023095-4dannjjm 3723 24 , , , cord-023095-4dannjjm 3723 25 mixed mixed JJ cord-023095-4dannjjm 3723 26 sex sex NN cord-023095-4dannjjm 3723 27 beagles beagle NNS cord-023095-4dannjjm 3723 28 for for IN cord-023095-4dannjjm 3723 29 up up IN cord-023095-4dannjjm 3723 30 to to TO cord-023095-4dannjjm 3723 31 7 7 CD cord-023095-4dannjjm 3723 32 days day NNS cord-023095-4dannjjm 3723 33 . . . cord-023095-4dannjjm 3724 1 Blood blood NN cord-023095-4dannjjm 3724 2 ( ( -LRB- cord-023095-4dannjjm 3724 3 weekly weekly NN cord-023095-4dannjjm 3724 4 for for IN cord-023095-4dannjjm 3724 5 12 12 CD cord-023095-4dannjjm 3724 6 weeks week NNS cord-023095-4dannjjm 3724 7 ) ) -RRB- cord-023095-4dannjjm 3724 8 , , , cord-023095-4dannjjm 3724 9 serum serum NN cord-023095-4dannjjm 3724 10 ( ( -LRB- cord-023095-4dannjjm 3724 11 weekly weekly NN cord-023095-4dannjjm 3724 12 for for IN cord-023095-4dannjjm 3724 13 12 12 CD cord-023095-4dannjjm 3724 14 weeks week NNS cord-023095-4dannjjm 3724 15 ) ) -RRB- cord-023095-4dannjjm 3724 16 , , , cord-023095-4dannjjm 3724 17 and and CC cord-023095-4dannjjm 3724 18 synovial synovial JJ cord-023095-4dannjjm 3724 19 fluid fluid NN cord-023095-4dannjjm 3724 20 ( ( -LRB- cord-023095-4dannjjm 3724 21 radiocarpal radiocarpal NNP cord-023095-4dannjjm 3724 22 joint joint NN cord-023095-4dannjjm 3724 23 ; ; : cord-023095-4dannjjm 3724 24 alternating alternate VBG cord-023095-4dannjjm 3724 25 arthrocentesis arthrocentesis NNP cord-023095-4dannjjm 3724 26 weekly weekly NN cord-023095-4dannjjm 3724 27 for for IN cord-023095-4dannjjm 3724 28 6 6 CD cord-023095-4dannjjm 3724 29 weeks week NNS cord-023095-4dannjjm 3724 30 ) ) -RRB- cord-023095-4dannjjm 3724 31 were be VBD cord-023095-4dannjjm 3724 32 collected collect VBN cord-023095-4dannjjm 3724 33 prior prior RB cord-023095-4dannjjm 3724 34 to to TO cord-023095-4dannjjm 3724 35 tick tick VB cord-023095-4dannjjm 3724 36 attachment attachment NN cord-023095-4dannjjm 3724 37 and and CC cord-023095-4dannjjm 3724 38 then then RB cord-023095-4dannjjm 3724 39 weekly weekly RB cord-023095-4dannjjm 3724 40 after after IN cord-023095-4dannjjm 3724 41 tick tick NN cord-023095-4dannjjm 3724 42 attachment attachment NN cord-023095-4dannjjm 3724 43 . . . cord-023095-4dannjjm 3725 1 Joint joint JJ cord-023095-4dannjjm 3725 2 fluid fluid JJ cord-023095-4dannjjm 3725 3 cytology cytology NN cord-023095-4dannjjm 3725 4 was be VBD cord-023095-4dannjjm 3725 5 performed perform VBN cord-023095-4dannjjm 3725 6 and and CC cord-023095-4dannjjm 3725 7 total total JJ cord-023095-4dannjjm 3725 8 DNA DNA NNP cord-023095-4dannjjm 3725 9 was be VBD cord-023095-4dannjjm 3725 10 extracted extract VBN cord-023095-4dannjjm 3725 11 from from IN cord-023095-4dannjjm 3725 12 blood blood NN cord-023095-4dannjjm 3725 13 and and CC cord-023095-4dannjjm 3725 14 synovial synovial JJ cord-023095-4dannjjm 3725 15 fluid fluid NN cord-023095-4dannjjm 3725 16 and and CC cord-023095-4dannjjm 3725 17 assayed assay VBN cord-023095-4dannjjm 3725 18 in in IN cord-023095-4dannjjm 3725 19 a a DT cord-023095-4dannjjm 3725 20 proprietary proprietary JJ cord-023095-4dannjjm 3725 21 real real JJ cord-023095-4dannjjm 3725 22 time time NN cord-023095-4dannjjm 3725 23 PCR pcr NN cord-023095-4dannjjm 3725 24 assay assay NN cord-023095-4dannjjm 3725 25 ( ( -LRB- cord-023095-4dannjjm 3725 26 FastPanel FastPanel NNP cord-023095-4dannjjm 3725 27 TM TM NNP cord-023095-4dannjjm 3725 28 ) ) -RRB- cord-023095-4dannjjm 3725 29 that that WDT cord-023095-4dannjjm 3725 30 amplifies amplify VBZ cord-023095-4dannjjm 3725 31 the the DT cord-023095-4dannjjm 3725 32 DNA DNA NNP cord-023095-4dannjjm 3725 33 of of IN cord-023095-4dannjjm 3725 34 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3725 35 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3725 36 , , , cord-023095-4dannjjm 3725 37 A. a. NN cord-023095-4dannjjm 3725 38 platys platy NNS cord-023095-4dannjjm 3725 39 , , , cord-023095-4dannjjm 3725 40 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 3725 41 canis canis NN cord-023095-4dannjjm 3725 42 , , , cord-023095-4dannjjm 3725 43 E. E. NNP cord-023095-4dannjjm 3725 44 chaffeensis chaffeensis NN cord-023095-4dannjjm 3725 45 , , , cord-023095-4dannjjm 3725 46 and and CC cord-023095-4dannjjm 3725 47 E. E. NNP cord-023095-4dannjjm 3725 48 ewingii ewingii NNP cord-023095-4dannjjm 3725 49 . . . cord-023095-4dannjjm 3726 1 Serum serum NN cord-023095-4dannjjm 3726 2 was be VBD cord-023095-4dannjjm 3726 3 assayed assay VBN cord-023095-4dannjjm 3726 4 for for IN cord-023095-4dannjjm 3726 5 A. a. JJ cord-023095-4dannjjm 3726 6 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3726 7 antibodies antibody NNS cord-023095-4dannjjm 3726 8 by by IN cord-023095-4dannjjm 3726 9 IFA IFA NNP cord-023095-4dannjjm 3726 10 . . . cord-023095-4dannjjm 3727 1 Time time NN cord-023095-4dannjjm 3727 2 to to IN cord-023095-4dannjjm 3727 3 first first JJ cord-023095-4dannjjm 3727 4 positive positive JJ cord-023095-4dannjjm 3727 5 results result NNS cord-023095-4dannjjm 3727 6 for for IN cord-023095-4dannjjm 3727 7 serology serology NN cord-023095-4dannjjm 3727 8 and and CC cord-023095-4dannjjm 3727 9 PCR PCR NNP cord-023095-4dannjjm 3727 10 were be VBD cord-023095-4dannjjm 3727 11 compared compare VBN cord-023095-4dannjjm 3727 12 by by IN cord-023095-4dannjjm 3727 13 paired pair VBN cord-023095-4dannjjm 3727 14 Student Student NNP cord-023095-4dannjjm 3727 15 's 's POS cord-023095-4dannjjm 3727 16 t t NN cord-023095-4dannjjm 3727 17 test test NN cord-023095-4dannjjm 3727 18 . . . cord-023095-4dannjjm 3728 1 None none NN cord-023095-4dannjjm 3728 2 of of IN cord-023095-4dannjjm 3728 3 the the DT cord-023095-4dannjjm 3728 4 beagles beagle NNS cord-023095-4dannjjm 3728 5 developed develop VBD cord-023095-4dannjjm 3728 6 clinical clinical JJ cord-023095-4dannjjm 3728 7 evidence evidence NN cord-023095-4dannjjm 3728 8 of of IN cord-023095-4dannjjm 3728 9 disease disease NN cord-023095-4dannjjm 3728 10 , , , cord-023095-4dannjjm 3728 11 and and CC cord-023095-4dannjjm 3728 12 no no DT cord-023095-4dannjjm 3728 13 major major JJ cord-023095-4dannjjm 3728 14 changes change NNS cord-023095-4dannjjm 3728 15 in in IN cord-023095-4dannjjm 3728 16 synovial synovial JJ cord-023095-4dannjjm 3728 17 fluid fluid NN cord-023095-4dannjjm 3728 18 cytology cytology NN cord-023095-4dannjjm 3728 19 were be VBD cord-023095-4dannjjm 3728 20 detected detect VBN cord-023095-4dannjjm 3728 21 over over IN cord-023095-4dannjjm 3728 22 time time NN cord-023095-4dannjjm 3728 23 . . . cord-023095-4dannjjm 3729 1 Of of IN cord-023095-4dannjjm 3729 2 the the DT cord-023095-4dannjjm 3729 3 18 18 CD cord-023095-4dannjjm 3729 4 beagles beagle NNS cord-023095-4dannjjm 3729 5 , , , cord-023095-4dannjjm 3729 6 15 15 CD cord-023095-4dannjjm 3729 7 were be VBD cord-023095-4dannjjm 3729 8 positive positive JJ cord-023095-4dannjjm 3729 9 for for IN cord-023095-4dannjjm 3729 10 A. a. NN cord-023095-4dannjjm 3729 11 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3729 12 DNA dna NN cord-023095-4dannjjm 3729 13 in in IN cord-023095-4dannjjm 3729 14 blood blood NN cord-023095-4dannjjm 3729 15 or or CC cord-023095-4dannjjm 3729 16 synovial synovial JJ cord-023095-4dannjjm 3729 17 fluid fluid NN cord-023095-4dannjjm 3729 18 or or CC cord-023095-4dannjjm 3729 19 IFA IFA NNP cord-023095-4dannjjm 3730 1 antibodies antibody NNS cord-023095-4dannjjm 3730 2 in in IN cord-023095-4dannjjm 3730 3 at at RB cord-023095-4dannjjm 3730 4 least least RBS cord-023095-4dannjjm 3730 5 one one CD cord-023095-4dannjjm 3730 6 sample sample NN cord-023095-4dannjjm 3730 7 after after IN cord-023095-4dannjjm 3730 8 tick tick NN cord-023095-4dannjjm 3730 9 attachment attachment NN cord-023095-4dannjjm 3730 10 . . . cord-023095-4dannjjm 3731 1 Antibody antibody NN cord-023095-4dannjjm 3731 2 titers titer NNS cord-023095-4dannjjm 3731 3 appeared appear VBD cord-023095-4dannjjm 3731 4 in in IN cord-023095-4dannjjm 3731 5 14 14 CD cord-023095-4dannjjm 3731 6 of of IN cord-023095-4dannjjm 3731 7 15 15 CD cord-023095-4dannjjm 3731 8 dogs dog NNS cord-023095-4dannjjm 3731 9 from from IN cord-023095-4dannjjm 3731 10 weeks week NNS cord-023095-4dannjjm 3731 11 2 2 CD cord-023095-4dannjjm 3731 12 to to IN cord-023095-4dannjjm 3731 13 12 12 CD cord-023095-4dannjjm 3731 14 ( ( -LRB- cord-023095-4dannjjm 3731 15 median median NN cord-023095-4dannjjm 3731 16 to to IN cord-023095-4dannjjm 3731 17 1 1 CD cord-023095-4dannjjm 3731 18 st st NNP cord-023095-4dannjjm 3731 19 positive positive JJ cord-023095-4dannjjm 3731 20 5 5 CD cord-023095-4dannjjm 3731 21 3 3 CD cord-023095-4dannjjm 3731 22 weeks week NNS cord-023095-4dannjjm 3731 23 AE AE NNP cord-023095-4dannjjm 3731 24 1 1 CD cord-023095-4dannjjm 3731 25 ) ) -RRB- cord-023095-4dannjjm 3731 26 . . . cord-023095-4dannjjm 3732 1 Titer titer NN cord-023095-4dannjjm 3732 2 magnitude magnitude NN cord-023095-4dannjjm 3732 3 ranged range VBD cord-023095-4dannjjm 3732 4 from from IN cord-023095-4dannjjm 3732 5 1:40 1:40 CD cord-023095-4dannjjm 3732 6 to to IN cord-023095-4dannjjm 3732 7 1:10,240 1:10,240 CD cord-023095-4dannjjm 3732 8 . . . cord-023095-4dannjjm 3733 1 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3733 2 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3733 3 DNA DNA NNP cord-023095-4dannjjm 3733 4 was be VBD cord-023095-4dannjjm 3733 5 amplified amplify VBN cord-023095-4dannjjm 3733 6 from from IN cord-023095-4dannjjm 3733 7 the the DT cord-023095-4dannjjm 3733 8 blood blood NN cord-023095-4dannjjm 3733 9 of of IN cord-023095-4dannjjm 3733 10 14 14 CD cord-023095-4dannjjm 3733 11 of of IN cord-023095-4dannjjm 3733 12 15 15 CD cord-023095-4dannjjm 3733 13 dogs dog NNS cord-023095-4dannjjm 3733 14 with with IN cord-023095-4dannjjm 3733 15 positive positive JJ cord-023095-4dannjjm 3733 16 test test NN cord-023095-4dannjjm 3733 17 results result NNS cord-023095-4dannjjm 3733 18 ranging range VBG cord-023095-4dannjjm 3733 19 from from IN cord-023095-4dannjjm 3733 20 1 1 CD cord-023095-4dannjjm 3733 21 to to TO cord-023095-4dannjjm 3733 22 12 12 CD cord-023095-4dannjjm 3733 23 weeks week NNS cord-023095-4dannjjm 3733 24 ( ( -LRB- cord-023095-4dannjjm 3733 25 median median NN cord-023095-4dannjjm 3733 26 to to IN cord-023095-4dannjjm 3733 27 1 1 CD cord-023095-4dannjjm 3733 28 st st NNP cord-023095-4dannjjm 3733 29 positive positive JJ cord-023095-4dannjjm 3733 30 5 5 CD cord-023095-4dannjjm 3733 31 2 2 CD cord-023095-4dannjjm 3733 32 weeks week NNS cord-023095-4dannjjm 3733 33 AE AE NNP cord-023095-4dannjjm 3733 34 1.5 1.5 CD cord-023095-4dannjjm 3733 35 ) ) -RRB- cord-023095-4dannjjm 3733 36 . . . cord-023095-4dannjjm 3734 1 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3734 2 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3734 3 DNA DNA NNP cord-023095-4dannjjm 3734 4 was be VBD cord-023095-4dannjjm 3734 5 amplified amplify VBN cord-023095-4dannjjm 3734 6 from from IN cord-023095-4dannjjm 3734 7 synovial synovial JJ cord-023095-4dannjjm 3734 8 fluid fluid NN cord-023095-4dannjjm 3734 9 from from IN cord-023095-4dannjjm 3734 10 8 8 CD cord-023095-4dannjjm 3734 11 of of IN cord-023095-4dannjjm 3734 12 15 15 CD cord-023095-4dannjjm 3734 13 dogs dog NNS cord-023095-4dannjjm 3734 14 between between IN cord-023095-4dannjjm 3734 15 weeks week NNS cord-023095-4dannjjm 3734 16 1 1 CD cord-023095-4dannjjm 3734 17 to to IN cord-023095-4dannjjm 3734 18 4 4 CD cord-023095-4dannjjm 3734 19 ( ( -LRB- cord-023095-4dannjjm 3734 20 median median NN cord-023095-4dannjjm 3734 21 to to IN cord-023095-4dannjjm 3734 22 1 1 CD cord-023095-4dannjjm 3734 23 st st NNP cord-023095-4dannjjm 3734 24 positive positive JJ cord-023095-4dannjjm 3734 25 5 5 CD cord-023095-4dannjjm 3734 26 4 4 CD cord-023095-4dannjjm 3734 27 weeks week NNS cord-023095-4dannjjm 3734 28 AE AE NNP cord-023095-4dannjjm 3734 29 1 1 CD cord-023095-4dannjjm 3734 30 ) ) -RRB- cord-023095-4dannjjm 3734 31 . . . cord-023095-4dannjjm 3735 1 Of of IN cord-023095-4dannjjm 3735 2 the the DT cord-023095-4dannjjm 3735 3 8 8 CD cord-023095-4dannjjm 3735 4 dogs dog NNS cord-023095-4dannjjm 3735 5 , , , cord-023095-4dannjjm 3735 6 7 7 CD cord-023095-4dannjjm 3735 7 were be VBD cord-023095-4dannjjm 3735 8 PCR PCR NNP cord-023095-4dannjjm 3735 9 positive positive JJ cord-023095-4dannjjm 3735 10 for for IN cord-023095-4dannjjm 3735 11 only only RB cord-023095-4dannjjm 3735 12 one one CD cord-023095-4dannjjm 3735 13 week week NN cord-023095-4dannjjm 3735 14 and and CC cord-023095-4dannjjm 3735 15 1 1 CD cord-023095-4dannjjm 3735 16 dog dog NN cord-023095-4dannjjm 3735 17 was be VBD cord-023095-4dannjjm 3735 18 PCR PCR NNP cord-023095-4dannjjm 3735 19 positive positive JJ cord-023095-4dannjjm 3735 20 for for IN cord-023095-4dannjjm 3735 21 two two CD cord-023095-4dannjjm 3735 22 consecutive consecutive JJ cord-023095-4dannjjm 3735 23 weeks week NNS cord-023095-4dannjjm 3735 24 . . . cord-023095-4dannjjm 3736 1 Of of IN cord-023095-4dannjjm 3736 2 the the DT cord-023095-4dannjjm 3736 3 15 15 CD cord-023095-4dannjjm 3736 4 dogs dog NNS cord-023095-4dannjjm 3736 5 , , , cord-023095-4dannjjm 3736 6 13 13 CD cord-023095-4dannjjm 3736 7 were be VBD cord-023095-4dannjjm 3736 8 positive positive JJ cord-023095-4dannjjm 3736 9 for for IN cord-023095-4dannjjm 3736 10 A. a. NN cord-023095-4dannjjm 3736 11 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3736 12 in in IN cord-023095-4dannjjm 3736 13 both both CC cord-023095-4dannjjm 3736 14 blood blood NN cord-023095-4dannjjm 3736 15 and and CC cord-023095-4dannjjm 3736 16 joints joint NNS cord-023095-4dannjjm 3736 17 by by IN cord-023095-4dannjjm 3736 18 DNA dna NN cord-023095-4dannjjm 3736 19 analysis analysis NN cord-023095-4dannjjm 3736 20 . . . cord-023095-4dannjjm 3737 1 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3737 2 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3737 3 DNA DNA NNP cord-023095-4dannjjm 3737 4 was be VBD cord-023095-4dannjjm 3737 5 amplified amplify VBN cord-023095-4dannjjm 3737 6 from from IN cord-023095-4dannjjm 3737 7 blood blood NN cord-023095-4dannjjm 3737 8 more more RBR cord-023095-4dannjjm 3737 9 quickly quickly RB cord-023095-4dannjjm 3737 10 than than IN cord-023095-4dannjjm 3737 11 seroconversion seroconversion NN cord-023095-4dannjjm 3737 12 was be VBD cord-023095-4dannjjm 3737 13 detected detect VBN cord-023095-4dannjjm 3737 14 by by IN cord-023095-4dannjjm 3737 15 IFA IFA NNP cord-023095-4dannjjm 3737 16 antibody antibody NN cord-023095-4dannjjm 3737 17 titer titer NN cord-023095-4dannjjm 3737 18 ( ( -LRB- cord-023095-4dannjjm 3737 19 t t NN cord-023095-4dannjjm 3737 20 5 5 CD cord-023095-4dannjjm 3737 21 À3.4 À3.4 NNP cord-023095-4dannjjm 3737 22 , , , cord-023095-4dannjjm 3737 23 P p NN cord-023095-4dannjjm 3737 24 o o NN cord-023095-4dannjjm 3737 25 0.01 0.01 CD cord-023095-4dannjjm 3737 26 ) ) -RRB- cord-023095-4dannjjm 3737 27 or or CC cord-023095-4dannjjm 3737 28 DNA DNA NNP cord-023095-4dannjjm 3737 29 was be VBD cord-023095-4dannjjm 3737 30 amplified amplify VBN cord-023095-4dannjjm 3737 31 from from IN cord-023095-4dannjjm 3737 32 synovial synovial JJ cord-023095-4dannjjm 3737 33 fluid fluid NN cord-023095-4dannjjm 3737 34 ( ( -LRB- cord-023095-4dannjjm 3737 35 t t NN cord-023095-4dannjjm 3737 36 5 5 CD cord-023095-4dannjjm 3737 37 5.4 5.4 CD cord-023095-4dannjjm 3737 38 , , , cord-023095-4dannjjm 3737 39 P p NN cord-023095-4dannjjm 3737 40 o o NN cord-023095-4dannjjm 3737 41 0.001 0.001 CD cord-023095-4dannjjm 3737 42 ) ) -RRB- cord-023095-4dannjjm 3737 43 . . . cord-023095-4dannjjm 3738 1 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3738 2 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3738 3 DNA dna NN cord-023095-4dannjjm 3738 4 can can MD cord-023095-4dannjjm 3738 5 be be VB cord-023095-4dannjjm 3738 6 amplified amplify VBN cord-023095-4dannjjm 3738 7 from from IN cord-023095-4dannjjm 3738 8 the the DT cord-023095-4dannjjm 3738 9 blood blood NN cord-023095-4dannjjm 3738 10 prior prior RB cord-023095-4dannjjm 3738 11 to to IN cord-023095-4dannjjm 3738 12 development development NN cord-023095-4dannjjm 3738 13 of of IN cord-023095-4dannjjm 3738 14 detectable detectable JJ cord-023095-4dannjjm 3738 15 antibody antibody NN cord-023095-4dannjjm 3738 16 titers titer NNS cord-023095-4dannjjm 3738 17 by by IN cord-023095-4dannjjm 3738 18 IFA IFA NNP cord-023095-4dannjjm 3738 19 . . . cord-023095-4dannjjm 3739 1 Amplification amplification NN cord-023095-4dannjjm 3739 2 of of IN cord-023095-4dannjjm 3739 3 A. a. JJ cord-023095-4dannjjm 3739 4 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3739 5 DNA dna NN cord-023095-4dannjjm 3739 6 from from IN cord-023095-4dannjjm 3739 7 synovial synovial JJ cord-023095-4dannjjm 3739 8 fluid fluid NN cord-023095-4dannjjm 3739 9 does do VBZ cord-023095-4dannjjm 3739 10 not not RB cord-023095-4dannjjm 3739 11 occur occur VB cord-023095-4dannjjm 3739 12 in in IN cord-023095-4dannjjm 3739 13 all all DT cord-023095-4dannjjm 3739 14 dogs dog NNS cord-023095-4dannjjm 3739 15 , , , cord-023095-4dannjjm 3739 16 appears appear VBZ cord-023095-4dannjjm 3739 17 to to TO cord-023095-4dannjjm 3739 18 be be VB cord-023095-4dannjjm 3739 19 transient transient JJ cord-023095-4dannjjm 3739 20 in in IN cord-023095-4dannjjm 3739 21 most most JJS cord-023095-4dannjjm 3739 22 dogs dog NNS cord-023095-4dannjjm 3739 23 , , , cord-023095-4dannjjm 3739 24 and and CC cord-023095-4dannjjm 3739 25 a a DT cord-023095-4dannjjm 3739 26 negative negative JJ cord-023095-4dannjjm 3739 27 test test NN cord-023095-4dannjjm 3739 28 result result NN cord-023095-4dannjjm 3739 29 does do VBZ cord-023095-4dannjjm 3739 30 not not RB cord-023095-4dannjjm 3739 31 preclude preclude VB cord-023095-4dannjjm 3739 32 a a DT cord-023095-4dannjjm 3739 33 diagnosis diagnosis NN cord-023095-4dannjjm 3739 34 of of IN cord-023095-4dannjjm 3739 35 A. a. JJ cord-023095-4dannjjm 3739 36 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3739 37 infection infection NN cord-023095-4dannjjm 3739 38 . . . cord-023095-4dannjjm 3740 1 Canine canine JJ cord-023095-4dannjjm 3740 2 granulocytic granulocytic JJ cord-023095-4dannjjm 3740 3 anaplasmosis anaplasmosis NN cord-023095-4dannjjm 3740 4 and and CC cord-023095-4dannjjm 3740 5 granulocytic granulocytic NNP cord-023095-4dannjjm 3740 6 ehrlichiosis ehrlichiosis NNP cord-023095-4dannjjm 3740 7 are be VBP cord-023095-4dannjjm 3740 8 tick tick NN cord-023095-4dannjjm 3740 9 - - HYPH cord-023095-4dannjjm 3740 10 transmitted transmit VBN cord-023095-4dannjjm 3740 11 infections infection NNS cord-023095-4dannjjm 3740 12 caused cause VBN cord-023095-4dannjjm 3740 13 by by IN cord-023095-4dannjjm 3740 14 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3740 15 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3740 16 ( ( -LRB- cord-023095-4dannjjm 3740 17 Aph Aph NNP cord-023095-4dannjjm 3740 18 ) ) -RRB- cord-023095-4dannjjm 3740 19 and and CC cord-023095-4dannjjm 3740 20 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 3740 21 ewingii ewingii NNS cord-023095-4dannjjm 3740 22 ( ( -LRB- cord-023095-4dannjjm 3740 23 Eew Eew NNP cord-023095-4dannjjm 3740 24 ) ) -RRB- cord-023095-4dannjjm 3740 25 , , , cord-023095-4dannjjm 3740 26 respectively respectively RB cord-023095-4dannjjm 3740 27 . . . cord-023095-4dannjjm 3741 1 Both both DT cord-023095-4dannjjm 3741 2 organisms organism NNS cord-023095-4dannjjm 3741 3 induce induce VBP cord-023095-4dannjjm 3741 4 an an DT cord-023095-4dannjjm 3741 5 acute acute JJ cord-023095-4dannjjm 3741 6 clinical clinical JJ cord-023095-4dannjjm 3741 7 disease disease NN cord-023095-4dannjjm 3741 8 , , , cord-023095-4dannjjm 3741 9 frequently frequently RB cord-023095-4dannjjm 3741 10 accompanied accompany VBN cord-023095-4dannjjm 3741 11 by by IN cord-023095-4dannjjm 3741 12 fever fever NN cord-023095-4dannjjm 3741 13 , , , cord-023095-4dannjjm 3741 14 polyarthropathy polyarthropathy NNP cord-023095-4dannjjm 3741 15 and and CC cord-023095-4dannjjm 3741 16 thrombocytopenia thrombocytopenia NN cord-023095-4dannjjm 3741 17 . . . cord-023095-4dannjjm 3742 1 However however RB cord-023095-4dannjjm 3742 2 , , , cord-023095-4dannjjm 3742 3 Aph Aph NNP cord-023095-4dannjjm 3742 4 and and CC cord-023095-4dannjjm 3742 5 Eew Eew NNP cord-023095-4dannjjm 3742 6 have have VBP cord-023095-4dannjjm 3742 7 different different JJ cord-023095-4dannjjm 3742 8 tick tick NN cord-023095-4dannjjm 3742 9 vectors vector NNS cord-023095-4dannjjm 3742 10 , , , cord-023095-4dannjjm 3742 11 i.e. i.e. FW cord-023095-4dannjjm 3742 12 Ixodes Ixodes NNP cord-023095-4dannjjm 3742 13 scapularis scapularis NN cord-023095-4dannjjm 3742 14 and and CC cord-023095-4dannjjm 3742 15 Ambylomma Ambylomma NNP cord-023095-4dannjjm 3742 16 americanum americanum NN cord-023095-4dannjjm 3742 17 , , , cord-023095-4dannjjm 3742 18 respectively respectively RB cord-023095-4dannjjm 3742 19 , , , cord-023095-4dannjjm 3742 20 with with IN cord-023095-4dannjjm 3742 21 different different JJ cord-023095-4dannjjm 3742 22 , , , cord-023095-4dannjjm 3742 23 but but CC cord-023095-4dannjjm 3742 24 overlapping overlap VBG cord-023095-4dannjjm 3742 25 geographic geographic JJ cord-023095-4dannjjm 3742 26 distributions distribution NNS cord-023095-4dannjjm 3742 27 . . . cord-023095-4dannjjm 3743 1 In in IN cord-023095-4dannjjm 3743 2 addition addition NN cord-023095-4dannjjm 3743 3 , , , cord-023095-4dannjjm 3743 4 infection infection NN cord-023095-4dannjjm 3743 5 outcome outcome NN cord-023095-4dannjjm 3743 6 may may MD cord-023095-4dannjjm 3743 7 be be VB cord-023095-4dannjjm 3743 8 affected affect VBN cord-023095-4dannjjm 3743 9 by by IN cord-023095-4dannjjm 3743 10 other other JJ cord-023095-4dannjjm 3743 11 regional regional JJ cord-023095-4dannjjm 3743 12 ticktransmitted ticktransmitte VBN cord-023095-4dannjjm 3743 13 pathogens pathogen NNS cord-023095-4dannjjm 3743 14 , , , cord-023095-4dannjjm 3743 15 such such JJ cord-023095-4dannjjm 3743 16 as as IN cord-023095-4dannjjm 3743 17 Borrelia Borrelia NNP cord-023095-4dannjjm 3743 18 burgdorferi burgdorferi NN cord-023095-4dannjjm 3743 19 ( ( -LRB- cord-023095-4dannjjm 3743 20 MN MN NNP cord-023095-4dannjjm 3743 21 ) ) -RRB- cord-023095-4dannjjm 3743 22 or or CC cord-023095-4dannjjm 3743 23 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 3743 24 chaffeensis chaffeensis NN cord-023095-4dannjjm 3743 25 ( ( -LRB- cord-023095-4dannjjm 3743 26 AR AR NNP cord-023095-4dannjjm 3743 27 ) ) -RRB- cord-023095-4dannjjm 3743 28 . . . cord-023095-4dannjjm 3744 1 Therefore therefore RB cord-023095-4dannjjm 3744 2 , , , cord-023095-4dannjjm 3744 3 we -PRON- PRP cord-023095-4dannjjm 3744 4 compared compare VBD cord-023095-4dannjjm 3744 5 serology serology NN cord-023095-4dannjjm 3744 6 and and CC cord-023095-4dannjjm 3744 7 PCR PCR NNP cord-023095-4dannjjm 3744 8 results result NNS cord-023095-4dannjjm 3744 9 derived derive VBN cord-023095-4dannjjm 3744 10 from from IN cord-023095-4dannjjm 3744 11 dogs dog NNS cord-023095-4dannjjm 3744 12 examined examine VBD cord-023095-4dannjjm 3744 13 at at IN cord-023095-4dannjjm 3744 14 two two CD cord-023095-4dannjjm 3744 15 private private JJ cord-023095-4dannjjm 3744 16 practices practice NNS cord-023095-4dannjjm 3744 17 located locate VBN cord-023095-4dannjjm 3744 18 in in IN cord-023095-4dannjjm 3744 19 highly highly RB cord-023095-4dannjjm 3744 20 endemic endemic JJ cord-023095-4dannjjm 3744 21 areas area NNS cord-023095-4dannjjm 3744 22 for for IN cord-023095-4dannjjm 3744 23 either either CC cord-023095-4dannjjm 3744 24 Aph Aph NNP cord-023095-4dannjjm 3744 25 or or CC cord-023095-4dannjjm 3744 26 Eew Eew NNP cord-023095-4dannjjm 3744 27 . . . cord-023095-4dannjjm 3745 1 Serum serum NN cord-023095-4dannjjm 3745 2 collected collect VBN cord-023095-4dannjjm 3745 3 between between IN cord-023095-4dannjjm 3745 4 April April NNP cord-023095-4dannjjm 3745 5 - - HYPH cord-023095-4dannjjm 3745 6 December December NNP cord-023095-4dannjjm 3745 7 , , , cord-023095-4dannjjm 3745 8 2005 2005 CD cord-023095-4dannjjm 3745 9 from from IN cord-023095-4dannjjm 3745 10 Minnesota Minnesota NNP cord-023095-4dannjjm 3745 11 dogs dog NNS cord-023095-4dannjjm 3745 12 ( ( -LRB- cord-023095-4dannjjm 3745 13 n n NN cord-023095-4dannjjm 3745 14 5 5 CD cord-023095-4dannjjm 3745 15 420 420 CD cord-023095-4dannjjm 3745 16 ) ) -RRB- cord-023095-4dannjjm 3745 17 was be VBD cord-023095-4dannjjm 3745 18 tested test VBN cord-023095-4dannjjm 3745 19 by by IN cord-023095-4dannjjm 3745 20 SNAP SNAP NNP cord-023095-4dannjjm 3745 21 s s NNP cord-023095-4dannjjm 3745 22 4Dx 4dx JJ cord-023095-4dannjjm 3745 23 s s NNS cord-023095-4dannjjm 3745 24 and and CC cord-023095-4dannjjm 3745 25 whole whole JJ cord-023095-4dannjjm 3745 26 blood blood NN cord-023095-4dannjjm 3745 27 was be VBD cord-023095-4dannjjm 3745 28 tested test VBN cord-023095-4dannjjm 3745 29 by by IN cord-023095-4dannjjm 3745 30 Aph Aph NNP cord-023095-4dannjjm 3745 31 PCR PCR NNP cord-023095-4dannjjm 3745 32 . . . cord-023095-4dannjjm 3746 1 Serum serum NN cord-023095-4dannjjm 3746 2 collected collect VBN cord-023095-4dannjjm 3746 3 from from IN cord-023095-4dannjjm 3746 4 Arkansas Arkansas NNP cord-023095-4dannjjm 3746 5 dogs dog NNS cord-023095-4dannjjm 3746 6 ( ( -LRB- cord-023095-4dannjjm 3746 7 n n NN cord-023095-4dannjjm 3746 8 5 5 CD cord-023095-4dannjjm 3746 9 708 708 CD cord-023095-4dannjjm 3746 10 ) ) -RRB- cord-023095-4dannjjm 3746 11 for for IN cord-023095-4dannjjm 3746 12 1 1 CD cord-023095-4dannjjm 3746 13 year year NN cord-023095-4dannjjm 3746 14 beginning beginning NN cord-023095-4dannjjm 3746 15 in in IN cord-023095-4dannjjm 3746 16 August August NNP cord-023095-4dannjjm 3746 17 2009 2009 CD cord-023095-4dannjjm 3746 18 was be VBD cord-023095-4dannjjm 3746 19 tested test VBN cord-023095-4dannjjm 3746 20 using use VBG cord-023095-4dannjjm 3746 21 microtiter microtiter NN cord-023095-4dannjjm 3746 22 plate plate NN cord-023095-4dannjjm 3746 23 ELISAs elisa NNS cord-023095-4dannjjm 3746 24 for for IN cord-023095-4dannjjm 3746 25 antibodies antibody NNS cord-023095-4dannjjm 3746 26 to to IN cord-023095-4dannjjm 3746 27 Eew Eew NNP cord-023095-4dannjjm 3746 28 , , , cord-023095-4dannjjm 3746 29 E. E. NNP cord-023095-4dannjjm 3746 30 canis canis NNP cord-023095-4dannjjm 3746 31 , , , cord-023095-4dannjjm 3746 32 and and CC cord-023095-4dannjjm 3746 33 E. E. NNP cord-023095-4dannjjm 3746 34 chaffeensis chaffeensis FW cord-023095-4dannjjm 3746 35 ( ( -LRB- cord-023095-4dannjjm 3746 36 Ech Ech NNP cord-023095-4dannjjm 3746 37 ) ) -RRB- cord-023095-4dannjjm 3746 38 while while IN cord-023095-4dannjjm 3746 39 whole whole JJ cord-023095-4dannjjm 3746 40 blood blood NN cord-023095-4dannjjm 3746 41 was be VBD cord-023095-4dannjjm 3746 42 tested test VBN cord-023095-4dannjjm 3746 43 by by IN cord-023095-4dannjjm 3746 44 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 3746 45 PCR PCR NNP cord-023095-4dannjjm 3746 46 . . . cord-023095-4dannjjm 3747 1 Comparisons comparison NNS cord-023095-4dannjjm 3747 2 were be VBD cord-023095-4dannjjm 3747 3 evaluated evaluate VBN cord-023095-4dannjjm 3747 4 using use VBG cord-023095-4dannjjm 3747 5 Chi Chi NNP cord-023095-4dannjjm 3747 6 Square Square NNP cord-023095-4dannjjm 3747 7 ( ( -LRB- cord-023095-4dannjjm 3747 8 Ã Ã NNP cord-023095-4dannjjm 3747 9 ) ) -RRB- cord-023095-4dannjjm 3747 10 and and CC cord-023095-4dannjjm 3747 11 Binomial Binomial NNP cord-023095-4dannjjm 3747 12 ( ( -LRB- cord-023095-4dannjjm 3747 13 w w NN cord-023095-4dannjjm 3747 14 ) ) -RRB- cord-023095-4dannjjm 3747 15 tests test VBZ cord-023095-4dannjjm 3747 16 with with IN cord-023095-4dannjjm 3747 17 an an DT cord-023095-4dannjjm 3747 18 alpha alpha NN cord-023095-4dannjjm 3747 19 of of IN cord-023095-4dannjjm 3747 20 5 5 CD cord-023095-4dannjjm 3747 21 % % NN cord-023095-4dannjjm 3747 22 . . . cord-023095-4dannjjm 3748 1 The the DT cord-023095-4dannjjm 3748 2 above above JJ cord-023095-4dannjjm 3748 3 results result NNS cord-023095-4dannjjm 3748 4 indicated indicate VBD cord-023095-4dannjjm 3748 5 that that IN cord-023095-4dannjjm 3748 6 dogs dog NNS cord-023095-4dannjjm 3748 7 are be VBP cord-023095-4dannjjm 3748 8 frequently frequently RB cord-023095-4dannjjm 3748 9 exposed expose VBN cord-023095-4dannjjm 3748 10 to to IN cord-023095-4dannjjm 3748 11 both both CC cord-023095-4dannjjm 3748 12 Aph Aph NNP cord-023095-4dannjjm 3748 13 and and CC cord-023095-4dannjjm 3748 14 Bb Bb NNP cord-023095-4dannjjm 3748 15 in in IN cord-023095-4dannjjm 3748 16 MN MN NNP cord-023095-4dannjjm 3748 17 , , , cord-023095-4dannjjm 3748 18 whereas whereas IN cord-023095-4dannjjm 3748 19 AR AR NNP cord-023095-4dannjjm 3748 20 dogs dog NNS cord-023095-4dannjjm 3748 21 are be VBP cord-023095-4dannjjm 3748 22 often often RB cord-023095-4dannjjm 3748 23 exposed expose VBN cord-023095-4dannjjm 3748 24 to to IN cord-023095-4dannjjm 3748 25 Eew Eew NNP cord-023095-4dannjjm 3748 26 , , , cord-023095-4dannjjm 3748 27 but but CC cord-023095-4dannjjm 3748 28 less less RBR cord-023095-4dannjjm 3748 29 frequently frequently RB cord-023095-4dannjjm 3748 30 to to IN cord-023095-4dannjjm 3748 31 Ech Ech NNP cord-023095-4dannjjm 3748 32 . . . cord-023095-4dannjjm 3749 1 Antibodies antibody NNS cord-023095-4dannjjm 3749 2 to to IN cord-023095-4dannjjm 3749 3 E. E. NNP cord-023095-4dannjjm 3749 4 canis canis NN cord-023095-4dannjjm 3749 5 peptides peptide NNS cord-023095-4dannjjm 3749 6 were be VBD cord-023095-4dannjjm 3749 7 found find VBN cord-023095-4dannjjm 3749 8 infrequently infrequently RB cord-023095-4dannjjm 3749 9 in in IN cord-023095-4dannjjm 3749 10 both both CC cord-023095-4dannjjm 3749 11 MN MN NNP cord-023095-4dannjjm 3749 12 and and CC cord-023095-4dannjjm 3749 13 AR AR NNP cord-023095-4dannjjm 3749 14 with with IN cord-023095-4dannjjm 3749 15 only only RB cord-023095-4dannjjm 3749 16 10 10 CD cord-023095-4dannjjm 3749 17 seroreactive seroreactive JJ cord-023095-4dannjjm 3749 18 dogs dog NNS cord-023095-4dannjjm 3749 19 detected detect VBD cord-023095-4dannjjm 3749 20 in in IN cord-023095-4dannjjm 3749 21 both both DT cord-023095-4dannjjm 3749 22 locations location NNS cord-023095-4dannjjm 3749 23 . . . cord-023095-4dannjjm 3750 1 Active active JJ cord-023095-4dannjjm 3750 2 Eew Eew NNP cord-023095-4dannjjm 3750 3 infection infection NN cord-023095-4dannjjm 3750 4 , , , cord-023095-4dannjjm 3750 5 as as IN cord-023095-4dannjjm 3750 6 determined determine VBN cord-023095-4dannjjm 3750 7 by by IN cord-023095-4dannjjm 3750 8 PCR PCR NNP cord-023095-4dannjjm 3750 9 , , , cord-023095-4dannjjm 3750 10 was be VBD cord-023095-4dannjjm 3750 11 four four CD cord-023095-4dannjjm 3750 12 times time NNS cord-023095-4dannjjm 3750 13 more more RBR cord-023095-4dannjjm 3750 14 frequent frequent JJ cord-023095-4dannjjm 3750 15 in in IN cord-023095-4dannjjm 3750 16 AR AR NNP cord-023095-4dannjjm 3750 17 pet pet JJ cord-023095-4dannjjm 3750 18 dog dog NN cord-023095-4dannjjm 3750 19 seroreactors seroreactor NNS cord-023095-4dannjjm 3750 20 as as IN cord-023095-4dannjjm 3750 21 compared compare VBN cord-023095-4dannjjm 3750 22 to to IN cord-023095-4dannjjm 3750 23 active active JJ cord-023095-4dannjjm 3750 24 Aph Aph NNP cord-023095-4dannjjm 3750 25 infections infection NNS cord-023095-4dannjjm 3750 26 among among IN cord-023095-4dannjjm 3750 27 Aph Aph NNP cord-023095-4dannjjm 3750 28 seroreactors seroreactor NNS cord-023095-4dannjjm 3750 29 . . . cord-023095-4dannjjm 3751 1 Although although IN cord-023095-4dannjjm 3751 2 both both DT cord-023095-4dannjjm 3751 3 organisms organism NNS cord-023095-4dannjjm 3751 4 induce induce VBP cord-023095-4dannjjm 3751 5 acute acute JJ cord-023095-4dannjjm 3751 6 disease disease NN cord-023095-4dannjjm 3751 7 , , , cord-023095-4dannjjm 3751 8 the the DT cord-023095-4dannjjm 3751 9 number number NN cord-023095-4dannjjm 3751 10 of of IN cord-023095-4dannjjm 3751 11 Aph Aph NNP cord-023095-4dannjjm 3751 12 and and CC cord-023095-4dannjjm 3751 13 Eew Eew NNP cord-023095-4dannjjm 3751 14 PCR PCR NNP cord-023095-4dannjjm 3751 15 positive positive JJ cord-023095-4dannjjm 3751 16 dogs dog NNS cord-023095-4dannjjm 3751 17 that that WDT cord-023095-4dannjjm 3751 18 were be VBD cord-023095-4dannjjm 3751 19 also also RB cord-023095-4dannjjm 3751 20 seropositive seropositive JJ cord-023095-4dannjjm 3751 21 was be VBD cord-023095-4dannjjm 3751 22 relatively relatively RB cord-023095-4dannjjm 3751 23 high high JJ cord-023095-4dannjjm 3751 24 suggesting suggest VBG cord-023095-4dannjjm 3751 25 that that IN cord-023095-4dannjjm 3751 26 both both DT cord-023095-4dannjjm 3751 27 organisms organism NNS cord-023095-4dannjjm 3751 28 induce induce VBP cord-023095-4dannjjm 3751 29 persistent persistent JJ cord-023095-4dannjjm 3751 30 infections infection NNS cord-023095-4dannjjm 3751 31 or or CC cord-023095-4dannjjm 3751 32 that that IN cord-023095-4dannjjm 3751 33 dogs dog NNS cord-023095-4dannjjm 3751 34 are be VBP cord-023095-4dannjjm 3751 35 frequently frequently RB cord-023095-4dannjjm 3751 36 re re VBN cord-023095-4dannjjm 3751 37 - - JJ cord-023095-4dannjjm 3751 38 infected infected JJ cord-023095-4dannjjm 3751 39 , , , cord-023095-4dannjjm 3751 40 despite despite IN cord-023095-4dannjjm 3751 41 the the DT cord-023095-4dannjjm 3751 42 presence presence NN cord-023095-4dannjjm 3751 43 of of IN cord-023095-4dannjjm 3751 44 a a DT cord-023095-4dannjjm 3751 45 measurable measurable JJ cord-023095-4dannjjm 3751 46 humoral humoral JJ cord-023095-4dannjjm 3751 47 immune immune JJ cord-023095-4dannjjm 3751 48 response response NN cord-023095-4dannjjm 3751 49 . . . cord-023095-4dannjjm 3752 1 Additional additional JJ cord-023095-4dannjjm 3752 2 studies study NNS cord-023095-4dannjjm 3752 3 are be VBP cord-023095-4dannjjm 3752 4 needed need VBN cord-023095-4dannjjm 3752 5 to to TO cord-023095-4dannjjm 3752 6 determine determine VB cord-023095-4dannjjm 3752 7 regional regional JJ cord-023095-4dannjjm 3752 8 infection infection NN cord-023095-4dannjjm 3752 9 profiles profile NNS cord-023095-4dannjjm 3752 10 in in IN cord-023095-4dannjjm 3752 11 other other JJ cord-023095-4dannjjm 3752 12 areas area NNS cord-023095-4dannjjm 3752 13 that that WDT cord-023095-4dannjjm 3752 14 are be VBP cord-023095-4dannjjm 3752 15 endemic endemic JJ cord-023095-4dannjjm 3752 16 for for IN cord-023095-4dannjjm 3752 17 these these DT cord-023095-4dannjjm 3752 18 pathogens pathogen NNS cord-023095-4dannjjm 3752 19 . . . cord-023095-4dannjjm 3753 1 Anaplasma anaplasma NN cord-023095-4dannjjm 3753 2 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3753 3 and and CC cord-023095-4dannjjm 3753 4 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 3753 5 canis cani NNS cord-023095-4dannjjm 3753 6 are be VBP cord-023095-4dannjjm 3753 7 two two CD cord-023095-4dannjjm 3753 8 of of IN cord-023095-4dannjjm 3753 9 the the DT cord-023095-4dannjjm 3753 10 most most RBS cord-023095-4dannjjm 3753 11 common common JJ cord-023095-4dannjjm 3753 12 vector vector NN cord-023095-4dannjjm 3753 13 borne bear VBN cord-023095-4dannjjm 3753 14 disease disease NN cord-023095-4dannjjm 3753 15 agents agent NNS cord-023095-4dannjjm 3753 16 that that WDT cord-023095-4dannjjm 3753 17 infect infect VBP cord-023095-4dannjjm 3753 18 dogs dog NNS cord-023095-4dannjjm 3753 19 and and CC cord-023095-4dannjjm 3753 20 cats cat NNS cord-023095-4dannjjm 3753 21 . . . cord-023095-4dannjjm 3754 1 While while IN cord-023095-4dannjjm 3754 2 PCR PCR NNP cord-023095-4dannjjm 3754 3 assays assay NNS cord-023095-4dannjjm 3754 4 that that WDT cord-023095-4dannjjm 3754 5 amplify amplify VBP cord-023095-4dannjjm 3754 6 the the DT cord-023095-4dannjjm 3754 7 DNA dna NN cord-023095-4dannjjm 3754 8 of of IN cord-023095-4dannjjm 3754 9 these these DT cord-023095-4dannjjm 3754 10 agents agent NNS cord-023095-4dannjjm 3754 11 from from IN cord-023095-4dannjjm 3754 12 blood blood NN cord-023095-4dannjjm 3754 13 are be VBP cord-023095-4dannjjm 3754 14 currently currently RB cord-023095-4dannjjm 3754 15 available available JJ cord-023095-4dannjjm 3754 16 , , , cord-023095-4dannjjm 3754 17 there there EX cord-023095-4dannjjm 3754 18 is be VBZ cord-023095-4dannjjm 3754 19 minimal minimal JJ cord-023095-4dannjjm 3754 20 information information NN cord-023095-4dannjjm 3754 21 concerning concern VBG cord-023095-4dannjjm 3754 22 the the DT cord-023095-4dannjjm 3754 23 performance performance NN cord-023095-4dannjjm 3754 24 of of IN cord-023095-4dannjjm 3754 25 these these DT cord-023095-4dannjjm 3754 26 assays assay NNS cord-023095-4dannjjm 3754 27 in in IN cord-023095-4dannjjm 3754 28 different different JJ cord-023095-4dannjjm 3754 29 commercial commercial JJ cord-023095-4dannjjm 3754 30 laboratories laboratory NNS cord-023095-4dannjjm 3754 31 that that WDT cord-023095-4dannjjm 3754 32 utilize utilize VBP cord-023095-4dannjjm 3754 33 different different JJ cord-023095-4dannjjm 3754 34 techniques technique NNS cord-023095-4dannjjm 3754 35 . . . cord-023095-4dannjjm 3755 1 The the DT cord-023095-4dannjjm 3755 2 purpose purpose NN cord-023095-4dannjjm 3755 3 of of IN cord-023095-4dannjjm 3755 4 this this DT cord-023095-4dannjjm 3755 5 study study NN cord-023095-4dannjjm 3755 6 was be VBD cord-023095-4dannjjm 3755 7 to to TO cord-023095-4dannjjm 3755 8 compare compare VB cord-023095-4dannjjm 3755 9 the the DT cord-023095-4dannjjm 3755 10 E. E. NNP cord-023095-4dannjjm 3755 11 canis canis NN cord-023095-4dannjjm 3755 12 and and CC cord-023095-4dannjjm 3755 13 A. a. JJ cord-023095-4dannjjm 3755 14 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3755 15 results result NNS cord-023095-4dannjjm 3755 16 of of IN cord-023095-4dannjjm 3755 17 two two CD cord-023095-4dannjjm 3755 18 different different JJ cord-023095-4dannjjm 3755 19 laboratories laboratory NNS cord-023095-4dannjjm 3755 20 on on IN cord-023095-4dannjjm 3755 21 the the DT cord-023095-4dannjjm 3755 22 same same JJ cord-023095-4dannjjm 3755 23 samples sample NNS cord-023095-4dannjjm 3755 24 collected collect VBN cord-023095-4dannjjm 3755 25 from from IN cord-023095-4dannjjm 3755 26 client client NN cord-023095-4dannjjm 3755 27 - - HYPH cord-023095-4dannjjm 3755 28 owned own VBN cord-023095-4dannjjm 3755 29 animals animal NNS cord-023095-4dannjjm 3755 30 . . . cord-023095-4dannjjm 3756 1 Veterinarians veterinarian NNS cord-023095-4dannjjm 3756 2 in in IN cord-023095-4dannjjm 3756 3 3 3 CD cord-023095-4dannjjm 3756 4 states state NNS cord-023095-4dannjjm 3756 5 ( ( -LRB- cord-023095-4dannjjm 3756 6 AZ AZ NNP cord-023095-4dannjjm 3756 7 , , , cord-023095-4dannjjm 3756 8 MD MD NNP cord-023095-4dannjjm 3756 9 , , , cord-023095-4dannjjm 3756 10 CT CT NNP cord-023095-4dannjjm 3756 11 ) ) -RRB- cord-023095-4dannjjm 3756 12 were be VBD cord-023095-4dannjjm 3756 13 recruited recruit VBN cord-023095-4dannjjm 3756 14 to to TO cord-023095-4dannjjm 3756 15 participate participate VB cord-023095-4dannjjm 3756 16 in in IN cord-023095-4dannjjm 3756 17 the the DT cord-023095-4dannjjm 3756 18 study study NN cord-023095-4dannjjm 3756 19 based base VBN cord-023095-4dannjjm 3756 20 on on IN cord-023095-4dannjjm 3756 21 high high JJ cord-023095-4dannjjm 3756 22 prevalence prevalence NN cord-023095-4dannjjm 3756 23 rates rate NNS cord-023095-4dannjjm 3756 24 for for IN cord-023095-4dannjjm 3756 25 E. E. NNP cord-023095-4dannjjm 3756 26 canis canis NNP cord-023095-4dannjjm 3756 27 or or CC cord-023095-4dannjjm 3756 28 A. a. JJ cord-023095-4dannjjm 3756 29 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3756 30 infection infection NN cord-023095-4dannjjm 3756 31 . . . cord-023095-4dannjjm 3757 1 Blood blood NN cord-023095-4dannjjm 3757 2 in in IN cord-023095-4dannjjm 3757 3 EDTA EDTA NNP cord-023095-4dannjjm 3757 4 was be VBD cord-023095-4dannjjm 3757 5 collected collect VBN cord-023095-4dannjjm 3757 6 from from IN cord-023095-4dannjjm 3757 7 dogs dog NNS cord-023095-4dannjjm 3757 8 or or CC cord-023095-4dannjjm 3757 9 cats cat NNS cord-023095-4dannjjm 3757 10 with with IN cord-023095-4dannjjm 3757 11 fever fever NN cord-023095-4dannjjm 3757 12 , , , cord-023095-4dannjjm 3757 13 thrombocytopenia thrombocytopenia NN cord-023095-4dannjjm 3757 14 , , , cord-023095-4dannjjm 3757 15 or or CC cord-023095-4dannjjm 3757 16 clinical clinical JJ cord-023095-4dannjjm 3757 17 evidence evidence NN cord-023095-4dannjjm 3757 18 of of IN cord-023095-4dannjjm 3757 19 polyarthritis polyarthritis NNP cord-023095-4dannjjm 3757 20 and and CC cord-023095-4dannjjm 3757 21 an an DT cord-023095-4dannjjm 3757 22 equal equal JJ cord-023095-4dannjjm 3757 23 volume volume NN cord-023095-4dannjjm 3757 24 of of IN cord-023095-4dannjjm 3757 25 the the DT cord-023095-4dannjjm 3757 26 same same JJ cord-023095-4dannjjm 3757 27 blood blood NN cord-023095-4dannjjm 3757 28 sample sample NN cord-023095-4dannjjm 3757 29 was be VBD cord-023095-4dannjjm 3757 30 simultaneously simultaneously RB cord-023095-4dannjjm 3757 31 shipped ship VBN cord-023095-4dannjjm 3757 32 on on IN cord-023095-4dannjjm 3757 33 cold cold JJ cord-023095-4dannjjm 3757 34 packs pack NNS cord-023095-4dannjjm 3757 35 by by IN cord-023095-4dannjjm 3757 36 overnight overnight JJ cord-023095-4dannjjm 3757 37 express express NN cord-023095-4dannjjm 3757 38 to to IN cord-023095-4dannjjm 3757 39 Colorado Colorado NNP cord-023095-4dannjjm 3757 40 State State NNP cord-023095-4dannjjm 3757 41 and and CC cord-023095-4dannjjm 3757 42 to to IN cord-023095-4dannjjm 3757 43 Antech Antech NNP cord-023095-4dannjjm 3757 44 Diagnostics Diagnostics NNP cord-023095-4dannjjm 3757 45 . . . cord-023095-4dannjjm 3758 1 Standard standard JJ cord-023095-4dannjjm 3758 2 operating operating NN cord-023095-4dannjjm 3758 3 procedures procedure NNS cord-023095-4dannjjm 3758 4 at at IN cord-023095-4dannjjm 3758 5 each each DT cord-023095-4dannjjm 3758 6 laboratory laboratory NN cord-023095-4dannjjm 3758 7 were be VBD cord-023095-4dannjjm 3758 8 followed follow VBN cord-023095-4dannjjm 3758 9 for for IN cord-023095-4dannjjm 3758 10 total total JJ cord-023095-4dannjjm 3758 11 DNA dna NN cord-023095-4dannjjm 3758 12 extraction extraction NN cord-023095-4dannjjm 3758 13 and and CC cord-023095-4dannjjm 3758 14 amplification amplification NN cord-023095-4dannjjm 3758 15 of of IN cord-023095-4dannjjm 3758 16 GAPDH GAPDH NNP cord-023095-4dannjjm 3758 17 as as IN cord-023095-4dannjjm 3758 18 the the DT cord-023095-4dannjjm 3758 19 DNA dna NN cord-023095-4dannjjm 3758 20 control control NN cord-023095-4dannjjm 3758 21 . . . cord-023095-4dannjjm 3759 1 At at IN cord-023095-4dannjjm 3759 2 Colorado Colorado NNP cord-023095-4dannjjm 3759 3 State State NNP cord-023095-4dannjjm 3759 4 University University NNP cord-023095-4dannjjm 3759 5 , , , cord-023095-4dannjjm 3759 6 a a DT cord-023095-4dannjjm 3759 7 previously previously RB cord-023095-4dannjjm 3759 8 published publish VBN cord-023095-4dannjjm 3759 9 PCR PCR NNP cord-023095-4dannjjm 3759 10 assay assay NN cord-023095-4dannjjm 3759 11 that that WDT cord-023095-4dannjjm 3759 12 amplifies amplify VBZ cord-023095-4dannjjm 3759 13 the the DT cord-023095-4dannjjm 3759 14 DNA dna NN cord-023095-4dannjjm 3759 15 of of IN cord-023095-4dannjjm 3759 16 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 3759 17 spp spp NNS cord-023095-4dannjjm 3759 18 . . . cord-023095-4dannjjm 3760 1 , , , cord-023095-4dannjjm 3760 2 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3760 3 spp spp NNS cord-023095-4dannjjm 3760 4 . . . cord-023095-4dannjjm 3761 1 , , , cord-023095-4dannjjm 3761 2 Neorickettsia Neorickettsia NNP cord-023095-4dannjjm 3761 3 spp spp NNS cord-023095-4dannjjm 3761 4 . . . cord-023095-4dannjjm 3762 1 , , , cord-023095-4dannjjm 3763 1 and and CC cord-023095-4dannjjm 3763 2 Wolbachia Wolbachia NNP cord-023095-4dannjjm 3763 3 was be VBD cord-023095-4dannjjm 3763 4 performed perform VBN cord-023095-4dannjjm 3763 5 on on IN cord-023095-4dannjjm 3763 6 each each DT cord-023095-4dannjjm 3763 7 sample sample NN cord-023095-4dannjjm 3763 8 with with IN cord-023095-4dannjjm 3763 9 positive positive JJ cord-023095-4dannjjm 3763 10 amplicons amplicon NNS cord-023095-4dannjjm 3763 11 sequenced sequence VBN cord-023095-4dannjjm 3763 12 to to TO cord-023095-4dannjjm 3763 13 determine determine VB cord-023095-4dannjjm 3763 14 the the DT cord-023095-4dannjjm 3763 15 species specie NNS cord-023095-4dannjjm 3763 16 . . . cord-023095-4dannjjm 3764 1 At at IN cord-023095-4dannjjm 3764 2 Antech Antech NNP cord-023095-4dannjjm 3764 3 Diagnostics Diagnostics NNP cord-023095-4dannjjm 3764 4 , , , cord-023095-4dannjjm 3764 5 a a DT cord-023095-4dannjjm 3764 6 proprietary proprietary JJ cord-023095-4dannjjm 3764 7 real real JJ cord-023095-4dannjjm 3764 8 time time NN cord-023095-4dannjjm 3764 9 PCR pcr NN cord-023095-4dannjjm 3764 10 assay assay NN cord-023095-4dannjjm 3764 11 ( ( -LRB- cord-023095-4dannjjm 3764 12 FastPanel FastPanel NNP cord-023095-4dannjjm 3764 13 TM TM NNP cord-023095-4dannjjm 3764 14 ) ) -RRB- cord-023095-4dannjjm 3764 15 that that WDT cord-023095-4dannjjm 3764 16 amplifies amplify VBZ cord-023095-4dannjjm 3764 17 the the DT cord-023095-4dannjjm 3764 18 DNA DNA NNP cord-023095-4dannjjm 3764 19 of of IN cord-023095-4dannjjm 3764 20 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3764 21 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3764 22 , , , cord-023095-4dannjjm 3764 23 A. a. NN cord-023095-4dannjjm 3764 24 platys platy NNS cord-023095-4dannjjm 3764 25 , , , cord-023095-4dannjjm 3764 26 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 3764 27 canis canis NN cord-023095-4dannjjm 3764 28 , , , cord-023095-4dannjjm 3764 29 E. E. NNP cord-023095-4dannjjm 3764 30 chaffeensis chaffeensis NN cord-023095-4dannjjm 3764 31 , , , cord-023095-4dannjjm 3764 32 and and CC cord-023095-4dannjjm 3764 33 E. E. NNP cord-023095-4dannjjm 3764 34 ewingii ewingii NNP cord-023095-4dannjjm 3764 35 was be VBD cord-023095-4dannjjm 3764 36 performed perform VBN cord-023095-4dannjjm 3764 37 . . . cord-023095-4dannjjm 3765 1 In in IN cord-023095-4dannjjm 3765 2 the the DT cord-023095-4dannjjm 3765 3 study study NN cord-023095-4dannjjm 3765 4 to to IN cord-023095-4dannjjm 3765 5 date date NN cord-023095-4dannjjm 3765 6 , , , cord-023095-4dannjjm 3765 7 samples sample NNS cord-023095-4dannjjm 3765 8 from from IN cord-023095-4dannjjm 3765 9 35 35 CD cord-023095-4dannjjm 3765 10 animals animal NNS cord-023095-4dannjjm 3765 11 ( ( -LRB- cord-023095-4dannjjm 3765 12 30 30 CD cord-023095-4dannjjm 3765 13 dogs dog NNS cord-023095-4dannjjm 3765 14 and and CC cord-023095-4dannjjm 3765 15 5 5 CD cord-023095-4dannjjm 3765 16 cats cat NNS cord-023095-4dannjjm 3765 17 ) ) -RRB- cord-023095-4dannjjm 3765 18 have have VBP cord-023095-4dannjjm 3765 19 been be VBN cord-023095-4dannjjm 3765 20 assayed assay VBN cord-023095-4dannjjm 3765 21 at at IN cord-023095-4dannjjm 3765 22 both both DT cord-023095-4dannjjm 3765 23 laboratories laboratory NNS cord-023095-4dannjjm 3765 24 . . . cord-023095-4dannjjm 3766 1 DNA DNA NNP cord-023095-4dannjjm 3766 2 of of IN cord-023095-4dannjjm 3766 3 A. A. NNP cord-023095-4dannjjm 3766 4 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3766 5 ( ( -LRB- cord-023095-4dannjjm 3766 6 2 2 CD cord-023095-4dannjjm 3766 7 cats cat NNS cord-023095-4dannjjm 3766 8 and and CC cord-023095-4dannjjm 3766 9 2 2 CD cord-023095-4dannjjm 3766 10 dogs dog NNS cord-023095-4dannjjm 3766 11 ) ) -RRB- cord-023095-4dannjjm 3766 12 and and CC cord-023095-4dannjjm 3766 13 E. E. NNP cord-023095-4dannjjm 3766 14 canis canis NNP cord-023095-4dannjjm 3766 15 ( ( -LRB- cord-023095-4dannjjm 3766 16 1 1 CD cord-023095-4dannjjm 3766 17 dog dog NN cord-023095-4dannjjm 3766 18 ) ) -RRB- cord-023095-4dannjjm 3766 19 were be VBD cord-023095-4dannjjm 3766 20 amplified amplify VBN cord-023095-4dannjjm 3766 21 at at IN cord-023095-4dannjjm 3766 22 both both DT cord-023095-4dannjjm 3766 23 laboratories laboratory NNS cord-023095-4dannjjm 3766 24 with with IN cord-023095-4dannjjm 3766 25 a a DT cord-023095-4dannjjm 3766 26 percentage percentage NN cord-023095-4dannjjm 3766 27 agreement agreement NN cord-023095-4dannjjm 3766 28 between between IN cord-023095-4dannjjm 3766 29 laboratories laboratory NNS cord-023095-4dannjjm 3766 30 of of IN cord-023095-4dannjjm 3766 31 100 100 CD cord-023095-4dannjjm 3766 32 % % NN cord-023095-4dannjjm 3766 33 . . . cord-023095-4dannjjm 3767 1 The the DT cord-023095-4dannjjm 3767 2 results result NNS cord-023095-4dannjjm 3767 3 to to IN cord-023095-4dannjjm 3767 4 date date NN cord-023095-4dannjjm 3767 5 suggest suggest VBP cord-023095-4dannjjm 3767 6 that that IN cord-023095-4dannjjm 3767 7 the the DT cord-023095-4dannjjm 3767 8 assay assay NN cord-023095-4dannjjm 3767 9 results result NNS cord-023095-4dannjjm 3767 10 of of IN cord-023095-4dannjjm 3767 11 the the DT cord-023095-4dannjjm 3767 12 two two CD cord-023095-4dannjjm 3767 13 laboratories laboratory NNS cord-023095-4dannjjm 3767 14 for for IN cord-023095-4dannjjm 3767 15 A. a. NN cord-023095-4dannjjm 3767 16 phagocytophilum phagocytophilum NN cord-023095-4dannjjm 3767 17 and and CC cord-023095-4dannjjm 3767 18 E. E. NNP cord-023095-4dannjjm 3767 19 canis canis NNP cord-023095-4dannjjm 3767 20 are be VBP cord-023095-4dannjjm 3767 21 comparable comparable JJ cord-023095-4dannjjm 3767 22 . . . cord-023095-4dannjjm 3768 1 Ehrlichiosis Ehrlichiosis NNP cord-023095-4dannjjm 3768 2 and and CC cord-023095-4dannjjm 3768 3 Bartonellosis Bartonellosis NNP cord-023095-4dannjjm 3768 4 are be VBP cord-023095-4dannjjm 3768 5 zoonotic zoonotic JJ cord-023095-4dannjjm 3768 6 diseases disease NNS cord-023095-4dannjjm 3768 7 caused cause VBN cord-023095-4dannjjm 3768 8 by by IN cord-023095-4dannjjm 3768 9 extremely extremely RB cord-023095-4dannjjm 3768 10 small small JJ cord-023095-4dannjjm 3768 11 , , , cord-023095-4dannjjm 3768 12 obligate obligate VBP cord-023095-4dannjjm 3768 13 intracellular intracellular JJ cord-023095-4dannjjm 3768 14 bacteria bacteria NNS cord-023095-4dannjjm 3768 15 that that WDT cord-023095-4dannjjm 3768 16 require require VBP cord-023095-4dannjjm 3768 17 a a DT cord-023095-4dannjjm 3768 18 mammalian mammalian JJ cord-023095-4dannjjm 3768 19 reservoir reservoir NN cord-023095-4dannjjm 3768 20 and and CC cord-023095-4dannjjm 3768 21 a a DT cord-023095-4dannjjm 3768 22 blood blood NN cord-023095-4dannjjm 3768 23 sucking suck VBG cord-023095-4dannjjm 3768 24 arthropod arthropod JJ cord-023095-4dannjjm 3768 25 vector vector NN cord-023095-4dannjjm 3768 26 . . . cord-023095-4dannjjm 3769 1 Human human JJ cord-023095-4dannjjm 3769 2 ehrlichiosis ehrlichiosis NN cord-023095-4dannjjm 3769 3 is be VBZ cord-023095-4dannjjm 3769 4 present present JJ cord-023095-4dannjjm 3769 5 in in IN cord-023095-4dannjjm 3769 6 Peru Peru NNP cord-023095-4dannjjm 3769 7 , , , cord-023095-4dannjjm 3769 8 with with IN cord-023095-4dannjjm 3769 9 a a DT cord-023095-4dannjjm 3769 10 seroprevalence seroprevalence NN cord-023095-4dannjjm 3769 11 as as RB cord-023095-4dannjjm 3769 12 high high JJ cord-023095-4dannjjm 3769 13 as as IN cord-023095-4dannjjm 3769 14 23 23 CD cord-023095-4dannjjm 3769 15 % % NN cord-023095-4dannjjm 3769 16 in in IN cord-023095-4dannjjm 3769 17 the the DT cord-023095-4dannjjm 3769 18 highlands highland NNS cord-023095-4dannjjm 3769 19 . . . cord-023095-4dannjjm 3770 1 Bartonella Bartonella NNP cord-023095-4dannjjm 3770 2 species specie NNS cord-023095-4dannjjm 3770 3 in in IN cord-023095-4dannjjm 3770 4 humans human NNS cord-023095-4dannjjm 3770 5 were be VBD cord-023095-4dannjjm 3770 6 also also RB cord-023095-4dannjjm 3770 7 identified identify VBN cord-023095-4dannjjm 3770 8 in in IN cord-023095-4dannjjm 3770 9 Peru Peru NNP cord-023095-4dannjjm 3770 10 since since IN cord-023095-4dannjjm 3770 11 1905 1905 CD cord-023095-4dannjjm 3770 12 ( ( -LRB- cord-023095-4dannjjm 3770 13 B. B. NNP cord-023095-4dannjjm 3770 14 bacilliformis bacilliformis NNP cord-023095-4dannjjm 3770 15 ) ) -RRB- cord-023095-4dannjjm 3770 16 . . . cord-023095-4dannjjm 3771 1 Recently recently RB cord-023095-4dannjjm 3771 2 , , , cord-023095-4dannjjm 3771 3 a a DT cord-023095-4dannjjm 3771 4 new new JJ cord-023095-4dannjjm 3771 5 species specie NNS cord-023095-4dannjjm 3771 6 ( ( -LRB- cord-023095-4dannjjm 3771 7 B. B. NNP cord-023095-4dannjjm 3771 8 rochalimae rochalimae NNP cord-023095-4dannjjm 3771 9 ) ) -RRB- cord-023095-4dannjjm 3771 10 was be VBD cord-023095-4dannjjm 3771 11 isolated isolate VBN cord-023095-4dannjjm 3771 12 from from IN cord-023095-4dannjjm 3771 13 an an DT cord-023095-4dannjjm 3771 14 American american JJ cord-023095-4dannjjm 3771 15 woman woman NN cord-023095-4dannjjm 3771 16 who who WP cord-023095-4dannjjm 3771 17 became become VBD cord-023095-4dannjjm 3771 18 febrile febrile JJ cord-023095-4dannjjm 3771 19 after after IN cord-023095-4dannjjm 3771 20 travelling travel VBG cord-023095-4dannjjm 3771 21 to to IN cord-023095-4dannjjm 3771 22 Peru Peru NNP cord-023095-4dannjjm 3771 23 . . . cord-023095-4dannjjm 3772 1 Dogs dog NNS cord-023095-4dannjjm 3772 2 can can MD cord-023095-4dannjjm 3772 3 become become VB cord-023095-4dannjjm 3772 4 infected infect VBN cord-023095-4dannjjm 3772 5 with with IN cord-023095-4dannjjm 3772 6 the the DT cord-023095-4dannjjm 3772 7 same same JJ cord-023095-4dannjjm 3772 8 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 3772 9 species specie NNS cord-023095-4dannjjm 3772 10 , , , cord-023095-4dannjjm 3772 11 and and CC cord-023095-4dannjjm 3772 12 the the DT cord-023095-4dannjjm 3772 13 majority majority NN cord-023095-4dannjjm 3772 14 of of IN cord-023095-4dannjjm 3772 15 Bartonella Bartonella NNP cord-023095-4dannjjm 3772 16 species specie NNS cord-023095-4dannjjm 3772 17 that that WDT cord-023095-4dannjjm 3772 18 affect affect VBP cord-023095-4dannjjm 3772 19 human human JJ cord-023095-4dannjjm 3772 20 beings being NNS cord-023095-4dannjjm 3772 21 . . . cord-023095-4dannjjm 3773 1 The the DT cord-023095-4dannjjm 3773 2 role role NN cord-023095-4dannjjm 3773 3 of of IN cord-023095-4dannjjm 3773 4 dogs dog NNS cord-023095-4dannjjm 3773 5 as as IN cord-023095-4dannjjm 3773 6 reservoirs reservoir NNS cord-023095-4dannjjm 3773 7 for for IN cord-023095-4dannjjm 3773 8 human human JJ cord-023095-4dannjjm 3773 9 infections infection NNS cord-023095-4dannjjm 3773 10 has have VBZ cord-023095-4dannjjm 3773 11 not not RB cord-023095-4dannjjm 3773 12 been be VBN cord-023095-4dannjjm 3773 13 clearly clearly RB cord-023095-4dannjjm 3773 14 established establish VBN cord-023095-4dannjjm 3773 15 , , , cord-023095-4dannjjm 3773 16 but but CC cord-023095-4dannjjm 3773 17 exposure exposure NN cord-023095-4dannjjm 3773 18 and/or and/or CC cord-023095-4dannjjm 3773 19 infection infection NN cord-023095-4dannjjm 3773 20 in in IN cord-023095-4dannjjm 3773 21 dogs dog NNS cord-023095-4dannjjm 3773 22 has have VBZ cord-023095-4dannjjm 3773 23 been be VBN cord-023095-4dannjjm 3773 24 used use VBN cord-023095-4dannjjm 3773 25 to to TO cord-023095-4dannjjm 3773 26 monitor monitor VB cord-023095-4dannjjm 3773 27 human human JJ cord-023095-4dannjjm 3773 28 exposure exposure NN cord-023095-4dannjjm 3773 29 to to TO cord-023095-4dannjjm 3773 30 tick tick VB cord-023095-4dannjjm 3773 31 - - HYPH cord-023095-4dannjjm 3773 32 borne bear VBN cord-023095-4dannjjm 3773 33 disease disease NN cord-023095-4dannjjm 3773 34 ( ( -LRB- cord-023095-4dannjjm 3773 35 TBD TBD NNP cord-023095-4dannjjm 3773 36 ) ) -RRB- cord-023095-4dannjjm 3773 37 , , , cord-023095-4dannjjm 3773 38 since since IN cord-023095-4dannjjm 3773 39 they -PRON- PRP cord-023095-4dannjjm 3773 40 share share VBP cord-023095-4dannjjm 3773 41 the the DT cord-023095-4dannjjm 3773 42 same same JJ cord-023095-4dannjjm 3773 43 environment environment NN cord-023095-4dannjjm 3773 44 . . . cord-023095-4dannjjm 3774 1 The the DT cord-023095-4dannjjm 3774 2 objective objective NN cord-023095-4dannjjm 3774 3 of of IN cord-023095-4dannjjm 3774 4 this this DT cord-023095-4dannjjm 3774 5 study study NN cord-023095-4dannjjm 3774 6 was be VBD cord-023095-4dannjjm 3774 7 to to TO cord-023095-4dannjjm 3774 8 determine determine VB cord-023095-4dannjjm 3774 9 the the DT cord-023095-4dannjjm 3774 10 serological serological JJ cord-023095-4dannjjm 3774 11 and and CC cord-023095-4dannjjm 3774 12 molecular molecular JJ cord-023095-4dannjjm 3774 13 prevalence prevalence NN cord-023095-4dannjjm 3774 14 of of IN cord-023095-4dannjjm 3774 15 Anaplasmosis Anaplasmosis NNP cord-023095-4dannjjm 3774 16 , , , cord-023095-4dannjjm 3774 17 Ehrlichiosis Ehrlichiosis NNP cord-023095-4dannjjm 3774 18 and and CC cord-023095-4dannjjm 3774 19 Bartonellosis Bartonellosis NNP cord-023095-4dannjjm 3774 20 in in IN cord-023095-4dannjjm 3774 21 rural rural JJ cord-023095-4dannjjm 3774 22 dogs dog NNS cord-023095-4dannjjm 3774 23 in in IN cord-023095-4dannjjm 3774 24 the the DT cord-023095-4dannjjm 3774 25 highlands highland NNS cord-023095-4dannjjm 3774 26 of of IN cord-023095-4dannjjm 3774 27 Peru Peru NNP cord-023095-4dannjjm 3774 28 . . . cord-023095-4dannjjm 3775 1 A a DT cord-023095-4dannjjm 3775 2 total total NN cord-023095-4dannjjm 3775 3 of of IN cord-023095-4dannjjm 3775 4 122 122 CD cord-023095-4dannjjm 3775 5 healthy healthy JJ cord-023095-4dannjjm 3775 6 adult adult NN cord-023095-4dannjjm 3775 7 dogs dog NNS cord-023095-4dannjjm 3775 8 were be VBD cord-023095-4dannjjm 3775 9 enrolled enrol VBN cord-023095-4dannjjm 3775 10 in in IN cord-023095-4dannjjm 3775 11 this this DT cord-023095-4dannjjm 3775 12 study study NN cord-023095-4dannjjm 3775 13 from from IN cord-023095-4dannjjm 3775 14 four four CD cord-023095-4dannjjm 3775 15 communities community NNS cord-023095-4dannjjm 3775 16 in in IN cord-023095-4dannjjm 3775 17 the the DT cord-023095-4dannjjm 3775 18 central central JJ cord-023095-4dannjjm 3775 19 highlands highland NNS cord-023095-4dannjjm 3775 20 of of IN cord-023095-4dannjjm 3775 21 Peru Peru NNP cord-023095-4dannjjm 3775 22 : : : cord-023095-4dannjjm 3775 23 Ondores Ondores NNP cord-023095-4dannjjm 3775 24 , , , cord-023095-4dannjjm 3775 25 Pachacayo Pachacayo NNP cord-023095-4dannjjm 3775 26 , , , cord-023095-4dannjjm 3775 27 San San NNP cord-023095-4dannjjm 3775 28 Juan Juan NNP cord-023095-4dannjjm 3775 29 de de NNP cord-023095-4dannjjm 3775 30 Pachayo Pachayo NNP cord-023095-4dannjjm 3775 31 , , , cord-023095-4dannjjm 3775 32 and and CC cord-023095-4dannjjm 3775 33 Canchayllo Canchayllo NNP cord-023095-4dannjjm 3775 34 . . . cord-023095-4dannjjm 3776 1 EDTA edta NN cord-023095-4dannjjm 3776 2 - - HYPH cord-023095-4dannjjm 3776 3 blood blood NN cord-023095-4dannjjm 3776 4 samples sample NNS cord-023095-4dannjjm 3776 5 were be VBD cord-023095-4dannjjm 3776 6 collected collect VBN cord-023095-4dannjjm 3776 7 from from IN cord-023095-4dannjjm 3776 8 108 108 CD cord-023095-4dannjjm 3776 9 dogs dog NNS cord-023095-4dannjjm 3776 10 , , , cord-023095-4dannjjm 3776 11 whereas whereas IN cord-023095-4dannjjm 3776 12 serum serum NN cord-023095-4dannjjm 3776 13 samples sample NNS cord-023095-4dannjjm 3776 14 were be VBD cord-023095-4dannjjm 3776 15 available available JJ cord-023095-4dannjjm 3776 16 from from IN cord-023095-4dannjjm 3776 17 110 110 CD cord-023095-4dannjjm 3776 18 dogs dog NNS cord-023095-4dannjjm 3776 19 . . . cord-023095-4dannjjm 3777 1 Serum serum NN cord-023095-4dannjjm 3777 2 samples sample NNS cord-023095-4dannjjm 3777 3 were be VBD cord-023095-4dannjjm 3777 4 tested test VBN cord-023095-4dannjjm 3777 5 for for IN cord-023095-4dannjjm 3777 6 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 3777 7 canis canis NN cord-023095-4dannjjm 3777 8 , , , cord-023095-4dannjjm 3777 9 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3777 10 , , , cord-023095-4dannjjm 3777 11 Borrelia Borrelia NNP cord-023095-4dannjjm 3777 12 burgdorferi burgdorferi NN cord-023095-4dannjjm 3777 13 and and CC cord-023095-4dannjjm 3777 14 Dirofilaria Dirofilaria NNP cord-023095-4dannjjm 3777 15 immitis immitis NNP cord-023095-4dannjjm 3777 16 infections infection NNS cord-023095-4dannjjm 3777 17 using use VBG cord-023095-4dannjjm 3777 18 a a DT cord-023095-4dannjjm 3777 19 qualitative qualitative JJ cord-023095-4dannjjm 3777 20 dot dot NN cord-023095-4dannjjm 3777 21 - - HYPH cord-023095-4dannjjm 3777 22 ELISA ELISA NNP cord-023095-4dannjjm 3777 23 ( ( -LRB- cord-023095-4dannjjm 3777 24 Snap snap VB cord-023095-4dannjjm 3777 25 s s POS cord-023095-4dannjjm 3777 26 4Dx 4dx CD cord-023095-4dannjjm 3777 27 ) ) -RRB- cord-023095-4dannjjm 3777 28 . . . cord-023095-4dannjjm 3778 1 The the DT cord-023095-4dannjjm 3778 2 EDTA edta NN cord-023095-4dannjjm 3778 3 - - HYPH cord-023095-4dannjjm 3778 4 blood blood NN cord-023095-4dannjjm 3778 5 samples sample NNS cord-023095-4dannjjm 3778 6 were be VBD cord-023095-4dannjjm 3778 7 screened screen VBN cord-023095-4dannjjm 3778 8 by by IN cord-023095-4dannjjm 3778 9 conventional conventional JJ cord-023095-4dannjjm 3778 10 PCR PCR NNP cord-023095-4dannjjm 3778 11 for for IN cord-023095-4dannjjm 3778 12 the the DT cord-023095-4dannjjm 3778 13 groEL groel JJ cord-023095-4dannjjm 3778 14 gene gene NN cord-023095-4dannjjm 3778 15 of of IN cord-023095-4dannjjm 3778 16 the the DT cord-023095-4dannjjm 3778 17 genus genus NNP cord-023095-4dannjjm 3778 18 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3778 19 and and CC cord-023095-4dannjjm 3778 20 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 3778 21 , , , cord-023095-4dannjjm 3778 22 and and CC cord-023095-4dannjjm 3778 23 for for IN cord-023095-4dannjjm 3778 24 the the DT cord-023095-4dannjjm 3778 25 intergenic intergenic JJ cord-023095-4dannjjm 3778 26 transcribed transcribe VBN cord-023095-4dannjjm 3778 27 spacer spacer NN cord-023095-4dannjjm 3778 28 of of IN cord-023095-4dannjjm 3778 29 the the DT cord-023095-4dannjjm 3778 30 genus genus NN cord-023095-4dannjjm 3778 31 Bartonella Bartonella NNP cord-023095-4dannjjm 3778 32 . . . cord-023095-4dannjjm 3779 1 Speciation speciation NN cord-023095-4dannjjm 3779 2 was be VBD cord-023095-4dannjjm 3779 3 conducted conduct VBN cord-023095-4dannjjm 3779 4 by by IN cord-023095-4dannjjm 3779 5 nucleotide nucleotide JJ cord-023095-4dannjjm 3779 6 sequencing sequencing NN cord-023095-4dannjjm 3779 7 . . . cord-023095-4dannjjm 3780 1 Bartonella Bartonella NNP cord-023095-4dannjjm 3780 2 genus genus NN cord-023095-4dannjjm 3780 3 DNA dna NN cord-023095-4dannjjm 3780 4 was be VBD cord-023095-4dannjjm 3780 5 detected detect VBN cord-023095-4dannjjm 3780 6 from from IN cord-023095-4dannjjm 3780 7 seven seven CD cord-023095-4dannjjm 3780 8 of of IN cord-023095-4dannjjm 3780 9 the the DT cord-023095-4dannjjm 3780 10 108 108 CD cord-023095-4dannjjm 3780 11 dogs dog NNS cord-023095-4dannjjm 3780 12 ( ( -LRB- cord-023095-4dannjjm 3780 13 6.5 6.5 CD cord-023095-4dannjjm 3780 14 % % NN cord-023095-4dannjjm 3780 15 ) ) -RRB- cord-023095-4dannjjm 3780 16 and and CC cord-023095-4dannjjm 3780 17 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 3780 18 canis canis NN cord-023095-4dannjjm 3780 19 DNA dna NN cord-023095-4dannjjm 3780 20 was be VBD cord-023095-4dannjjm 3780 21 detected detect VBN cord-023095-4dannjjm 3780 22 and and CC cord-023095-4dannjjm 3780 23 sequenced sequence VBN cord-023095-4dannjjm 3780 24 from from IN cord-023095-4dannjjm 3780 25 one one CD cord-023095-4dannjjm 3780 26 dog dog NN cord-023095-4dannjjm 3780 27 ( ( -LRB- cord-023095-4dannjjm 3780 28 0.9 0.9 CD cord-023095-4dannjjm 3780 29 % % NN cord-023095-4dannjjm 3780 30 ) ) -RRB- cord-023095-4dannjjm 3780 31 . . . cord-023095-4dannjjm 3781 1 Four four CD cord-023095-4dannjjm 3781 2 of of IN cord-023095-4dannjjm 3781 3 the the DT cord-023095-4dannjjm 3781 4 Bartonella Bartonella NNP cord-023095-4dannjjm 3781 5 positive positive JJ cord-023095-4dannjjm 3781 6 samples sample NNS cord-023095-4dannjjm 3781 7 were be VBD cord-023095-4dannjjm 3781 8 identified identify VBN cord-023095-4dannjjm 3781 9 by by IN cord-023095-4dannjjm 3781 10 DNA dna NN cord-023095-4dannjjm 3781 11 sequencing sequencing NN cord-023095-4dannjjm 3781 12 as as IN cord-023095-4dannjjm 3781 13 B. B. NNP cord-023095-4dannjjm 3781 14 rochalimae rochalimae NNP cord-023095-4dannjjm 3781 15 ( ( -LRB- cord-023095-4dannjjm 3781 16 GenBank GenBank NNP cord-023095-4dannjjm 3781 17 accession accession NN cord-023095-4dannjjm 3781 18 numbers number NNS cord-023095-4dannjjm 3781 19 HQ185696 hq185696 VBP cord-023095-4dannjjm 3781 20 and and CC cord-023095-4dannjjm 3781 21 HQ185695 HQ185695 NNP cord-023095-4dannjjm 3781 22 ) ) -RRB- cord-023095-4dannjjm 3781 23 . . . cord-023095-4dannjjm 3782 1 The the DT cord-023095-4dannjjm 3782 2 other other JJ cord-023095-4dannjjm 3782 3 three three CD cord-023095-4dannjjm 3782 4 Bartonella Bartonella NNP cord-023095-4dannjjm 3782 5 positive positive JJ cord-023095-4dannjjm 3782 6 samples sample NNS cord-023095-4dannjjm 3782 7 were be VBD cord-023095-4dannjjm 3782 8 identified identify VBN cord-023095-4dannjjm 3782 9 as as IN cord-023095-4dannjjm 3782 10 B. B. NNP cord-023095-4dannjjm 3782 11 vinsonii vinsonii NNP cord-023095-4dannjjm 3782 12 subspecies subspecies NNP cord-023095-4dannjjm 3782 13 berkhoffii berkhoffii NNP cord-023095-4dannjjm 3782 14 , , , cord-023095-4dannjjm 3782 15 the the DT cord-023095-4dannjjm 3782 16 causative causative JJ cord-023095-4dannjjm 3782 17 agent agent NN cord-023095-4dannjjm 3782 18 of of IN cord-023095-4dannjjm 3782 19 endocarditis endocarditis NN cord-023095-4dannjjm 3782 20 in in IN cord-023095-4dannjjm 3782 21 dogs dog NNS cord-023095-4dannjjm 3782 22 and and CC cord-023095-4dannjjm 3782 23 humans human NNS cord-023095-4dannjjm 3782 24 . . . cord-023095-4dannjjm 3783 1 No no DT cord-023095-4dannjjm 3783 2 dog dog NN cord-023095-4dannjjm 3783 3 was be VBD cord-023095-4dannjjm 3783 4 infected infect VBN cord-023095-4dannjjm 3783 5 with with IN cord-023095-4dannjjm 3783 6 Anaplasma Anaplasma NNP cord-023095-4dannjjm 3783 7 species specie NNS cord-023095-4dannjjm 3783 8 by by IN cord-023095-4dannjjm 3783 9 DNA dna NN cord-023095-4dannjjm 3783 10 amplification amplification NN cord-023095-4dannjjm 3783 11 , , , cord-023095-4dannjjm 3783 12 but but CC cord-023095-4dannjjm 3783 13 one one CD cord-023095-4dannjjm 3783 14 dog dog NN cord-023095-4dannjjm 3783 15 was be VBD cord-023095-4dannjjm 3783 16 seroreactive seroreactive JJ cord-023095-4dannjjm 3783 17 for for IN cord-023095-4dannjjm 3783 18 this this DT cord-023095-4dannjjm 3783 19 genus genus NN cord-023095-4dannjjm 3783 20 ( ( -LRB- cord-023095-4dannjjm 3783 21 0.9 0.9 CD cord-023095-4dannjjm 3783 22 % % NN cord-023095-4dannjjm 3783 23 ) ) -RRB- cord-023095-4dannjjm 3783 24 . . . cord-023095-4dannjjm 3784 1 No no DT cord-023095-4dannjjm 3784 2 specific specific JJ cord-023095-4dannjjm 3784 3 antibodies antibody NNS cord-023095-4dannjjm 3784 4 against against IN cord-023095-4dannjjm 3784 5 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 3784 6 canis canis NN cord-023095-4dannjjm 3784 7 and and CC cord-023095-4dannjjm 3784 8 Borrelia Borrelia NNP cord-023095-4dannjjm 3784 9 burgdorferi burgdorferi NN cord-023095-4dannjjm 3784 10 and and CC cord-023095-4dannjjm 3784 11 no no DT cord-023095-4dannjjm 3784 12 antigens antigen NNS cord-023095-4dannjjm 3784 13 of of IN cord-023095-4dannjjm 3784 14 Dirofilaria Dirofilaria NNP cord-023095-4dannjjm 3784 15 immitis immitis NNP cord-023095-4dannjjm 3784 16 were be VBD cord-023095-4dannjjm 3784 17 detected detect VBN cord-023095-4dannjjm 3784 18 . . . cord-023095-4dannjjm 3785 1 This this DT cord-023095-4dannjjm 3785 2 study study NN cord-023095-4dannjjm 3785 3 expands expand VBZ cord-023095-4dannjjm 3785 4 the the DT cord-023095-4dannjjm 3785 5 current current JJ cord-023095-4dannjjm 3785 6 knowledge knowledge NN cord-023095-4dannjjm 3785 7 about about IN cord-023095-4dannjjm 3785 8 TBD TBD NNP cord-023095-4dannjjm 3785 9 in in IN cord-023095-4dannjjm 3785 10 Peru Peru NNP cord-023095-4dannjjm 3785 11 and and CC cord-023095-4dannjjm 3785 12 describes describe VBZ cord-023095-4dannjjm 3785 13 for for IN cord-023095-4dannjjm 3785 14 the the DT cord-023095-4dannjjm 3785 15 first first JJ cord-023095-4dannjjm 3785 16 time time NN cord-023095-4dannjjm 3785 17 the the DT cord-023095-4dannjjm 3785 18 infection infection NN cord-023095-4dannjjm 3785 19 of of IN cord-023095-4dannjjm 3785 20 B. B. NNP cord-023095-4dannjjm 3785 21 rochalimae rochalimae NNP cord-023095-4dannjjm 3785 22 in in IN cord-023095-4dannjjm 3785 23 dogs dog NNS cord-023095-4dannjjm 3785 24 in in IN cord-023095-4dannjjm 3785 25 Peru Peru NNP cord-023095-4dannjjm 3785 26 . . . cord-023095-4dannjjm 3786 1 The the DT cord-023095-4dannjjm 3786 2 results result NNS cord-023095-4dannjjm 3786 3 suggest suggest VBP cord-023095-4dannjjm 3786 4 that that IN cord-023095-4dannjjm 3786 5 dogs dog NNS cord-023095-4dannjjm 3786 6 may may MD cord-023095-4dannjjm 3786 7 play play VB cord-023095-4dannjjm 3786 8 an an DT cord-023095-4dannjjm 3786 9 important important JJ cord-023095-4dannjjm 3786 10 role role NN cord-023095-4dannjjm 3786 11 in in IN cord-023095-4dannjjm 3786 12 the the DT cord-023095-4dannjjm 3786 13 epidemiology epidemiology NN cord-023095-4dannjjm 3786 14 of of IN cord-023095-4dannjjm 3786 15 this this DT cord-023095-4dannjjm 3786 16 infection infection NN cord-023095-4dannjjm 3786 17 in in IN cord-023095-4dannjjm 3786 18 humans human NNS cord-023095-4dannjjm 3786 19 , , , cord-023095-4dannjjm 3786 20 since since IN cord-023095-4dannjjm 3786 21 they -PRON- PRP cord-023095-4dannjjm 3786 22 can can MD cord-023095-4dannjjm 3786 23 be be VB cord-023095-4dannjjm 3786 24 asymptomatic asymptomatic JJ cord-023095-4dannjjm 3786 25 but but CC cord-023095-4dannjjm 3786 26 bacteremic bacteremic JJ cord-023095-4dannjjm 3786 27 . . . cord-023095-4dannjjm 3787 1 Bartonella Bartonella NNP cord-023095-4dannjjm 3787 2 spp spp NN cord-023095-4dannjjm 3787 3 . . . cord-023095-4dannjjm 3788 1 DNA DNA NNP cord-023095-4dannjjm 3788 2 is be VBZ cord-023095-4dannjjm 3788 3 commonly commonly RB cord-023095-4dannjjm 3788 4 amplified amplify VBN cord-023095-4dannjjm 3788 5 from from IN cord-023095-4dannjjm 3788 6 the the DT cord-023095-4dannjjm 3788 7 blood blood NN cord-023095-4dannjjm 3788 8 of of IN cord-023095-4dannjjm 3788 9 cats cat NNS cord-023095-4dannjjm 3788 10 exposed expose VBN cord-023095-4dannjjm 3788 11 to to IN cord-023095-4dannjjm 3788 12 Ctenocephalides Ctenocephalides NNP cord-023095-4dannjjm 3788 13 felis felis NN cord-023095-4dannjjm 3788 14 . . . cord-023095-4dannjjm 3789 1 In in IN cord-023095-4dannjjm 3789 2 previous previous JJ cord-023095-4dannjjm 3789 3 work work NN cord-023095-4dannjjm 3789 4 , , , cord-023095-4dannjjm 3789 5 it -PRON- PRP cord-023095-4dannjjm 3789 6 was be VBD cord-023095-4dannjjm 3789 7 shown show VBN cord-023095-4dannjjm 3789 8 that that IN cord-023095-4dannjjm 3789 9 cats cat NNS cord-023095-4dannjjm 3789 10 administered administer VBD cord-023095-4dannjjm 3789 11 imidacloprid imidacloprid NNP cord-023095-4dannjjm 3789 12 and and CC cord-023095-4dannjjm 3789 13 experimentally experimentally RB cord-023095-4dannjjm 3789 14 exposed expose VBN cord-023095-4dannjjm 3789 15 to to IN cord-023095-4dannjjm 3789 16 B. B. NNP cord-023095-4dannjjm 3789 17 henselae henselae NNP cord-023095-4dannjjm 3789 18 infected infect VBD cord-023095-4dannjjm 3789 19 cats cat NNS cord-023095-4dannjjm 3789 20 and and CC cord-023095-4dannjjm 3789 21 C. C. NNP cord-023095-4dannjjm 3789 22 felis felis NNP cord-023095-4dannjjm 3789 23 did do VBD cord-023095-4dannjjm 3789 24 not not RB cord-023095-4dannjjm 3789 25 become become VB cord-023095-4dannjjm 3789 26 PCR PCR NNP cord-023095-4dannjjm 3789 27 positive positive JJ cord-023095-4dannjjm 3789 28 for for IN cord-023095-4dannjjm 3789 29 B. B. NNP cord-023095-4dannjjm 3789 30 henselae henselae NNP cord-023095-4dannjjm 3789 31 whereas whereas IN cord-023095-4dannjjm 3789 32 untreated untreated JJ cord-023095-4dannjjm 3789 33 cats cat NNS cord-023095-4dannjjm 3789 34 all all DT cord-023095-4dannjjm 3789 35 developed develop VBD cord-023095-4dannjjm 3789 36 infection infection NN cord-023095-4dannjjm 3789 37 . . . cord-023095-4dannjjm 3790 1 The the DT cord-023095-4dannjjm 3790 2 purpose purpose NN cord-023095-4dannjjm 3790 3 of of IN cord-023095-4dannjjm 3790 4 this this DT cord-023095-4dannjjm 3790 5 study study NN cord-023095-4dannjjm 3790 6 was be VBD cord-023095-4dannjjm 3790 7 to to TO cord-023095-4dannjjm 3790 8 determine determine VB cord-023095-4dannjjm 3790 9 if if IN cord-023095-4dannjjm 3790 10 administration administration NN cord-023095-4dannjjm 3790 11 of of IN cord-023095-4dannjjm 3790 12 imidacloprid imidacloprid NNP cord-023095-4dannjjm 3790 13 to to IN cord-023095-4dannjjm 3790 14 clientowned clientowne VBN cord-023095-4dannjjm 3790 15 cats cat NNS cord-023095-4dannjjm 3790 16 likely likely JJ cord-023095-4dannjjm 3790 17 to to TO cord-023095-4dannjjm 3790 18 be be VB cord-023095-4dannjjm 3790 19 exposed expose VBN cord-023095-4dannjjm 3790 20 to to IN cord-023095-4dannjjm 3790 21 Bartonella Bartonella NNP cord-023095-4dannjjm 3790 22 spp spp NNS cord-023095-4dannjjm 3790 23 . . . cord-023095-4dannjjm 3791 1 and and CC cord-023095-4dannjjm 3791 2 C. C. NNP cord-023095-4dannjjm 3791 3 felis felis NN cord-023095-4dannjjm 3791 4 in in IN cord-023095-4dannjjm 3791 5 the the DT cord-023095-4dannjjm 3791 6 field field NN cord-023095-4dannjjm 3791 7 lessens lessen VBZ cord-023095-4dannjjm 3791 8 prevalence prevalence NN cord-023095-4dannjjm 3791 9 of of IN cord-023095-4dannjjm 3791 10 Bartonella Bartonella NNP cord-023095-4dannjjm 3791 11 spp spp NNS cord-023095-4dannjjm 3791 12 . . . cord-023095-4dannjjm 3792 1 infection infection NN cord-023095-4dannjjm 3792 2 . . . cord-023095-4dannjjm 3793 1 Veterinary veterinary JJ cord-023095-4dannjjm 3793 2 students student NNS cord-023095-4dannjjm 3793 3 in in IN cord-023095-4dannjjm 3793 4 Tennessee Tennessee NNP cord-023095-4dannjjm 3793 5 and and CC cord-023095-4dannjjm 3793 6 Florida Florida NNP cord-023095-4dannjjm 3793 7 that that WDT cord-023095-4dannjjm 3793 8 owned own VBD cord-023095-4dannjjm 3793 9 cats cat NNS cord-023095-4dannjjm 3793 10 that that WDT cord-023095-4dannjjm 3793 11 spent spend VBD cord-023095-4dannjjm 3793 12 at at IN cord-023095-4dannjjm 3793 13 least least RBS cord-023095-4dannjjm 3793 14 20 20 CD cord-023095-4dannjjm 3793 15 days day NNS cord-023095-4dannjjm 3793 16 per per IN cord-023095-4dannjjm 3793 17 month month NN cord-023095-4dannjjm 3793 18 outside outside RB cord-023095-4dannjjm 3794 1 and and CC cord-023095-4dannjjm 3794 2 that that DT cord-023095-4dannjjm 3794 3 were be VBD cord-023095-4dannjjm 3794 4 willing willing JJ cord-023095-4dannjjm 3794 5 to to TO cord-023095-4dannjjm 3794 6 apply apply VB cord-023095-4dannjjm 3794 7 imidacloprid imidacloprid NNP cord-023095-4dannjjm 3794 8 to to IN cord-023095-4dannjjm 3794 9 their -PRON- PRP$ cord-023095-4dannjjm 3794 10 cats cat NNS cord-023095-4dannjjm 3794 11 monthly monthly JJ cord-023095-4dannjjm 3794 12 for for IN cord-023095-4dannjjm 3794 13 six six CD cord-023095-4dannjjm 3794 14 months month NNS cord-023095-4dannjjm 3794 15 were be VBD cord-023095-4dannjjm 3794 16 recruited recruit VBN cord-023095-4dannjjm 3794 17 for for IN cord-023095-4dannjjm 3794 18 the the DT cord-023095-4dannjjm 3794 19 study study NN cord-023095-4dannjjm 3794 20 . . . cord-023095-4dannjjm 3795 1 Blood blood NN cord-023095-4dannjjm 3795 2 for for IN cord-023095-4dannjjm 3795 3 Bartonella Bartonella NNP cord-023095-4dannjjm 3795 4 spp spp NNS cord-023095-4dannjjm 3795 5 . . . cord-023095-4dannjjm 3796 1 PCR PCR NNP cord-023095-4dannjjm 3796 2 assay assay NN cord-023095-4dannjjm 3796 3 was be VBD cord-023095-4dannjjm 3796 4 collected collect VBN cord-023095-4dannjjm 3796 5 from from IN cord-023095-4dannjjm 3796 6 the the DT cord-023095-4dannjjm 3796 7 cats cat NNS cord-023095-4dannjjm 3796 8 seven seven CD cord-023095-4dannjjm 3796 9 months month NNS cord-023095-4dannjjm 3796 10 after after IN cord-023095-4dannjjm 3796 11 starting start VBG cord-023095-4dannjjm 3796 12 imidacloprid imidacloprid NNP cord-023095-4dannjjm 3796 13 administration administration NN cord-023095-4dannjjm 3796 14 and and CC cord-023095-4dannjjm 3796 15 assayed assay VBD cord-023095-4dannjjm 3796 16 at at IN cord-023095-4dannjjm 3796 17 Colorado Colorado NNP cord-023095-4dannjjm 3796 18 State State NNP cord-023095-4dannjjm 3796 19 University University NNP cord-023095-4dannjjm 3796 20 . . . cord-023095-4dannjjm 3797 1 To to TO cord-023095-4dannjjm 3797 2 serve serve VB cord-023095-4dannjjm 3797 3 as as IN cord-023095-4dannjjm 3797 4 a a DT cord-023095-4dannjjm 3797 5 control control NN cord-023095-4dannjjm 3797 6 group group NN cord-023095-4dannjjm 3797 7 that that WDT cord-023095-4dannjjm 3797 8 was be VBD cord-023095-4dannjjm 3797 9 unlikely unlikely JJ cord-023095-4dannjjm 3797 10 to to TO cord-023095-4dannjjm 3797 11 have have VB cord-023095-4dannjjm 3797 12 been be VBN cord-023095-4dannjjm 3797 13 administered administer VBN cord-023095-4dannjjm 3797 14 flea flea NN cord-023095-4dannjjm 3797 15 control control NN cord-023095-4dannjjm 3797 16 products product NNS cord-023095-4dannjjm 3797 17 in in IN cord-023095-4dannjjm 3797 18 the the DT cord-023095-4dannjjm 3797 19 previous previous JJ cord-023095-4dannjjm 3797 20 6 6 CD cord-023095-4dannjjm 3797 21 months month NNS cord-023095-4dannjjm 3797 22 , , , cord-023095-4dannjjm 3797 23 blood blood NN cord-023095-4dannjjm 3797 24 was be VBD cord-023095-4dannjjm 3797 25 collected collect VBN cord-023095-4dannjjm 3797 26 from from IN cord-023095-4dannjjm 3797 27 feral feral JJ cord-023095-4dannjjm 3797 28 cats cat NNS cord-023095-4dannjjm 3797 29 during during IN cord-023095-4dannjjm 3797 30 TNR TNR NNP cord-023095-4dannjjm 3797 31 programs program NNS cord-023095-4dannjjm 3797 32 in in IN cord-023095-4dannjjm 3797 33 each each DT cord-023095-4dannjjm 3797 34 of of IN cord-023095-4dannjjm 3797 35 the the DT cord-023095-4dannjjm 3797 36 two two CD cord-023095-4dannjjm 3797 37 cities city NNS cord-023095-4dannjjm 3797 38 and and CC cord-023095-4dannjjm 3797 39 assayed assay VBN cord-023095-4dannjjm 3797 40 for for IN cord-023095-4dannjjm 3797 41 Bartonella Bartonella NNP cord-023095-4dannjjm 3797 42 spp spp NNS cord-023095-4dannjjm 3797 43 . . . cord-023095-4dannjjm 3798 1 DNA DNA NNP cord-023095-4dannjjm 3798 2 . . . cord-023095-4dannjjm 3799 1 The the DT cord-023095-4dannjjm 3799 2 Bartonella Bartonella NNP cord-023095-4dannjjm 3799 3 spp spp NN cord-023095-4dannjjm 3799 4 . . . cord-023095-4dannjjm 3800 1 DNA dna NN cord-023095-4dannjjm 3800 2 prevalence prevalence NN cord-023095-4dannjjm 3800 3 rates rate NNS cord-023095-4dannjjm 3800 4 between between IN cord-023095-4dannjjm 3800 5 the the DT cord-023095-4dannjjm 3800 6 groups group NNS cord-023095-4dannjjm 3800 7 were be VBD cord-023095-4dannjjm 3800 8 compared compare VBN cord-023095-4dannjjm 3800 9 by by IN cord-023095-4dannjjm 3800 10 chi chi NNP cord-023095-4dannjjm 3800 11 square square NNP cord-023095-4dannjjm 3800 12 analysis analysis NN cord-023095-4dannjjm 3800 13 with with IN cord-023095-4dannjjm 3800 14 significance significance NN cord-023095-4dannjjm 3800 15 defined define VBN cord-023095-4dannjjm 3800 16 as as IN cord-023095-4dannjjm 3800 17 P p NN cord-023095-4dannjjm 3800 18 o o NN cord-023095-4dannjjm 3800 19 0.05 0.05 CD cord-023095-4dannjjm 3800 20 . . . cord-023095-4dannjjm 3801 1 The the DT cord-023095-4dannjjm 3801 2 overall overall JJ cord-023095-4dannjjm 3801 3 prevalence prevalence NN cord-023095-4dannjjm 3801 4 rates rate NNS cord-023095-4dannjjm 3801 5 for for IN cord-023095-4dannjjm 3801 6 Bartonella Bartonella NNP cord-023095-4dannjjm 3801 7 spp spp NNS cord-023095-4dannjjm 3801 8 . . . cord-023095-4dannjjm 3802 1 DNA DNA NNP cord-023095-4dannjjm 3802 2 in in IN cord-023095-4dannjjm 3802 3 the the DT cord-023095-4dannjjm 3802 4 blood blood NN cord-023095-4dannjjm 3802 5 of of IN cord-023095-4dannjjm 3802 6 veterinary veterinary JJ cord-023095-4dannjjm 3802 7 student student NN cord-023095-4dannjjm 3802 8 cats cat NNS cord-023095-4dannjjm 3802 9 ( ( -LRB- cord-023095-4dannjjm 3802 10 7.4 7.4 CD cord-023095-4dannjjm 3802 11 % % NN cord-023095-4dannjjm 3802 12 ) ) -RRB- cord-023095-4dannjjm 3802 13 and and CC cord-023095-4dannjjm 3802 14 the the DT cord-023095-4dannjjm 3802 15 feral feral JJ cord-023095-4dannjjm 3802 16 cats cat NNS cord-023095-4dannjjm 3802 17 ( ( -LRB- cord-023095-4dannjjm 3802 18 39.1 39.1 CD cord-023095-4dannjjm 3802 19 % % NN cord-023095-4dannjjm 3802 20 ) ) -RRB- cord-023095-4dannjjm 3802 21 were be VBD cord-023095-4dannjjm 3802 22 significantly significantly RB cord-023095-4dannjjm 3802 23 different different JJ cord-023095-4dannjjm 3802 24 ( ( -LRB- cord-023095-4dannjjm 3802 25 P p NN cord-023095-4dannjjm 3802 26 o o NN cord-023095-4dannjjm 3802 27 0.0001 0.0001 CD cord-023095-4dannjjm 3802 28 ) ) -RRB- cord-023095-4dannjjm 3802 29 . . . cord-023095-4dannjjm 3803 1 The the DT cord-023095-4dannjjm 3803 2 distribution distribution NN cord-023095-4dannjjm 3803 3 of of IN cord-023095-4dannjjm 3803 4 results result NNS cord-023095-4dannjjm 3803 5 is be VBZ cord-023095-4dannjjm 3803 6 shown show VBN cord-023095-4dannjjm 3803 7 in in IN cord-023095-4dannjjm 3803 8 Table Table NNP cord-023095-4dannjjm 3803 9 1 1 CD cord-023095-4dannjjm 3803 10 . . . cord-023095-4dannjjm 3804 1 The the DT cord-023095-4dannjjm 3804 2 results result NNS cord-023095-4dannjjm 3804 3 suggest suggest VBP cord-023095-4dannjjm 3804 4 that that IN cord-023095-4dannjjm 3804 5 Florida Florida NNP cord-023095-4dannjjm 3804 6 feral feral JJ cord-023095-4dannjjm 3804 7 cats cat NNS cord-023095-4dannjjm 3804 8 were be VBD cord-023095-4dannjjm 3804 9 more more RBR cord-023095-4dannjjm 3804 10 commonly commonly RB cord-023095-4dannjjm 3804 11 exposed expose VBN cord-023095-4dannjjm 3804 12 to to IN cord-023095-4dannjjm 3804 13 C. C. NNP cord-023095-4dannjjm 3804 14 felis felis NN cord-023095-4dannjjm 3804 15 than than IN cord-023095-4dannjjm 3804 16 Tennessee Tennessee NNP cord-023095-4dannjjm 3804 17 feral feral JJ cord-023095-4dannjjm 3804 18 cats cat NNS cord-023095-4dannjjm 3804 19 . . . cord-023095-4dannjjm 3805 1 While while IN cord-023095-4dannjjm 3805 2 the the DT cord-023095-4dannjjm 3805 3 cats cat NNS cord-023095-4dannjjm 3805 4 in in IN cord-023095-4dannjjm 3805 5 the the DT cord-023095-4dannjjm 3805 6 groups group NNS cord-023095-4dannjjm 3805 7 were be VBD cord-023095-4dannjjm 3805 8 not not RB cord-023095-4dannjjm 3805 9 exactly exactly RB cord-023095-4dannjjm 3805 10 matched match VBN cord-023095-4dannjjm 3805 11 , , , cord-023095-4dannjjm 3805 12 the the DT cord-023095-4dannjjm 3805 13 student student NN cord-023095-4dannjjm 3805 14 cats cat NNS cord-023095-4dannjjm 3805 15 were be VBD cord-023095-4dannjjm 3805 16 allowed allow VBN cord-023095-4dannjjm 3805 17 outdoors outdoors RB cord-023095-4dannjjm 3805 18 for for IN cord-023095-4dannjjm 3805 19 approximately approximately RB cord-023095-4dannjjm 3805 20 20 20 CD cord-023095-4dannjjm 3805 21 days day NNS cord-023095-4dannjjm 3805 22 per per IN cord-023095-4dannjjm 3805 23 month month NN cord-023095-4dannjjm 3805 24 and and CC cord-023095-4dannjjm 3805 25 lived live VBD cord-023095-4dannjjm 3805 26 in in IN cord-023095-4dannjjm 3805 27 the the DT cord-023095-4dannjjm 3805 28 same same JJ cord-023095-4dannjjm 3805 29 cities city NNS cord-023095-4dannjjm 3805 30 as as IN cord-023095-4dannjjm 3805 31 the the DT cord-023095-4dannjjm 3805 32 feral feral JJ cord-023095-4dannjjm 3805 33 cats cat NNS cord-023095-4dannjjm 3805 34 , , , cord-023095-4dannjjm 3805 35 so so RB cord-023095-4dannjjm 3805 36 C. C. NNP cord-023095-4dannjjm 3805 37 felis felis NN cord-023095-4dannjjm 3805 38 exposure exposure NN cord-023095-4dannjjm 3805 39 rates rate NNS cord-023095-4dannjjm 3805 40 were be VBD cord-023095-4dannjjm 3805 41 likely likely RB cord-023095-4dannjjm 3805 42 similar similar JJ cord-023095-4dannjjm 3805 43 . . . cord-023095-4dannjjm 3806 1 As as IN cord-023095-4dannjjm 3806 2 previously previously RB cord-023095-4dannjjm 3806 3 shown show VBN cord-023095-4dannjjm 3806 4 in in IN cord-023095-4dannjjm 3806 5 experimentally experimentally RB cord-023095-4dannjjm 3806 6 - - HYPH cord-023095-4dannjjm 3806 7 exposed expose VBN cord-023095-4dannjjm 3806 8 cats cat NNS cord-023095-4dannjjm 3806 9 , , , cord-023095-4dannjjm 3806 10 the the DT cord-023095-4dannjjm 3806 11 use use NN cord-023095-4dannjjm 3806 12 of of IN cord-023095-4dannjjm 3806 13 imidacloprid imidacloprid NNP cord-023095-4dannjjm 3806 14 monthly monthly JJ cord-023095-4dannjjm 3806 15 may may MD cord-023095-4dannjjm 3806 16 influence influence VB cord-023095-4dannjjm 3806 17 transmission transmission NN cord-023095-4dannjjm 3806 18 rates rate NNS cord-023095-4dannjjm 3806 19 of of IN cord-023095-4dannjjm 3806 20 Bartonella Bartonella NNP cord-023095-4dannjjm 3806 21 spp spp NNS cord-023095-4dannjjm 3806 22 . . . cord-023095-4dannjjm 3807 1 amongst amongst IN cord-023095-4dannjjm 3807 2 naturally naturally RB cord-023095-4dannjjm 3807 3 - - HYPH cord-023095-4dannjjm 3807 4 exposed expose VBN cord-023095-4dannjjm 3807 5 cats cat NNS cord-023095-4dannjjm 3807 6 . . . cord-023095-4dannjjm 3808 1 In in IN cord-023095-4dannjjm 3808 2 an an DT cord-023095-4dannjjm 3808 3 endemic endemic JJ cord-023095-4dannjjm 3808 4 area area NN cord-023095-4dannjjm 3808 5 for for IN cord-023095-4dannjjm 3808 6 leishmaniosis leishmaniosis NNP cord-023095-4dannjjm 3808 7 and and CC cord-023095-4dannjjm 3808 8 filariosis filariosis NNP cord-023095-4dannjjm 3808 9 , , , cord-023095-4dannjjm 3808 10 coinfection coinfection NN cord-023095-4dannjjm 3808 11 can can MD cord-023095-4dannjjm 3808 12 occur occur VB cord-023095-4dannjjm 3808 13 and and CC cord-023095-4dannjjm 3808 14 immunomodulation immunomodulation NN cord-023095-4dannjjm 3808 15 produced produce VBN cord-023095-4dannjjm 3808 16 by by IN cord-023095-4dannjjm 3808 17 Wolbachia Wolbachia NNP cord-023095-4dannjjm 3808 18 might may MD cord-023095-4dannjjm 3808 19 influence influence VB cord-023095-4dannjjm 3808 20 the the DT cord-023095-4dannjjm 3808 21 clinical clinical JJ cord-023095-4dannjjm 3808 22 signs sign NNS cord-023095-4dannjjm 3808 23 and and CC cord-023095-4dannjjm 3808 24 progression progression NN cord-023095-4dannjjm 3808 25 of of IN cord-023095-4dannjjm 3808 26 both both DT cord-023095-4dannjjm 3808 27 diseases disease NNS cord-023095-4dannjjm 3808 28 . . . cord-023095-4dannjjm 3809 1 The the DT cord-023095-4dannjjm 3809 2 aims aim NNS cord-023095-4dannjjm 3809 3 of of IN cord-023095-4dannjjm 3809 4 the the DT cord-023095-4dannjjm 3809 5 present present JJ cord-023095-4dannjjm 3809 6 study study NN cord-023095-4dannjjm 3809 7 were be VBD cord-023095-4dannjjm 3809 8 1 1 CD cord-023095-4dannjjm 3809 9 ) ) -RRB- cord-023095-4dannjjm 3809 10 to to TO cord-023095-4dannjjm 3809 11 determine determine VB cord-023095-4dannjjm 3809 12 the the DT cord-023095-4dannjjm 3809 13 prevalence prevalence NN cord-023095-4dannjjm 3809 14 of of IN cord-023095-4dannjjm 3809 15 Wolbachia Wolbachia NNP cord-023095-4dannjjm 3809 16 in in IN cord-023095-4dannjjm 3809 17 dogs dog NNS cord-023095-4dannjjm 3809 18 infected infect VBN cord-023095-4dannjjm 3809 19 with with IN cord-023095-4dannjjm 3809 20 Dirofilaria Dirofilaria NNP cord-023095-4dannjjm 3809 21 immitis immitis NNP cord-023095-4dannjjm 3809 22 ( ( -LRB- cord-023095-4dannjjm 3809 23 Di Di NNP cord-023095-4dannjjm 3809 24 ) ) -RRB- cord-023095-4dannjjm 3809 25 and and CC cord-023095-4dannjjm 3809 26 other other JJ cord-023095-4dannjjm 3809 27 filarial filarial JJ cord-023095-4dannjjm 3809 28 nematodes nematode NNS cord-023095-4dannjjm 3809 29 , , , cord-023095-4dannjjm 3809 30 2 2 CD cord-023095-4dannjjm 3809 31 ) ) -RRB- cord-023095-4dannjjm 3809 32 to to TO cord-023095-4dannjjm 3809 33 evaluate evaluate VB cord-023095-4dannjjm 3809 34 the the DT cord-023095-4dannjjm 3809 35 level level NN cord-023095-4dannjjm 3809 36 of of IN cord-023095-4dannjjm 3809 37 coinfection coinfection NN cord-023095-4dannjjm 3809 38 of of IN cord-023095-4dannjjm 3809 39 leishmaniosis leishmaniosis NNP cord-023095-4dannjjm 3809 40 and and CC cord-023095-4dannjjm 3809 41 filariosis filariosis NN cord-023095-4dannjjm 3809 42 by by IN cord-023095-4dannjjm 3809 43 molecular molecular JJ cord-023095-4dannjjm 3809 44 assays assay NNS cord-023095-4dannjjm 3809 45 and and CC cord-023095-4dannjjm 3809 46 3 3 CD cord-023095-4dannjjm 3809 47 ) ) -RRB- cord-023095-4dannjjm 3809 48 to to TO cord-023095-4dannjjm 3809 49 evaluate evaluate VB cord-023095-4dannjjm 3809 50 any any DT cord-023095-4dannjjm 3809 51 associations association NNS cord-023095-4dannjjm 3809 52 between between IN cord-023095-4dannjjm 3809 53 Leishmania Leishmania NNP cord-023095-4dannjjm 3809 54 infantum infantum NN cord-023095-4dannjjm 3809 55 ( ( -LRB- cord-023095-4dannjjm 3809 56 Li Li NNP cord-023095-4dannjjm 3809 57 ) ) -RRB- cord-023095-4dannjjm 3809 58 infection infection NN cord-023095-4dannjjm 3809 59 , , , cord-023095-4dannjjm 3809 60 filariosis filariosis NN cord-023095-4dannjjm 3809 61 with with IN cord-023095-4dannjjm 3809 62 or or CC cord-023095-4dannjjm 3809 63 without without IN cord-023095-4dannjjm 3809 64 Wolbachia Wolbachia NNP cord-023095-4dannjjm 3809 65 and and CC cord-023095-4dannjjm 3809 66 clinical clinical JJ cord-023095-4dannjjm 3809 67 presentation presentation NN cord-023095-4dannjjm 3809 68 and and CC cord-023095-4dannjjm 3809 69 outcome outcome NN cord-023095-4dannjjm 3809 70 . . . cord-023095-4dannjjm 3810 1 Statistical statistical JJ cord-023095-4dannjjm 3810 2 differences difference NNS cord-023095-4dannjjm 3810 3 between between IN cord-023095-4dannjjm 3810 4 groups group NNS cord-023095-4dannjjm 3810 5 were be VBD cord-023095-4dannjjm 3810 6 tested test VBN cord-023095-4dannjjm 3810 7 for for IN cord-023095-4dannjjm 3810 8 significance significance NN cord-023095-4dannjjm 3810 9 by by IN cord-023095-4dannjjm 3810 10 the the DT cord-023095-4dannjjm 3810 11 Fisher Fisher NNP cord-023095-4dannjjm 3810 12 exact exact JJ cord-023095-4dannjjm 3810 13 test test NN cord-023095-4dannjjm 3810 14 using use VBG cord-023095-4dannjjm 3810 15 SPSS SPSS NNP cord-023095-4dannjjm 3810 16 v.14.0 v.14.0 NNP cord-023095-4dannjjm 3810 17 software software NN cord-023095-4dannjjm 3810 18 ( ( -LRB- cord-023095-4dannjjm 3810 19 significance significance NN cord-023095-4dannjjm 3810 20 : : : cord-023095-4dannjjm 3810 21 p p NN cord-023095-4dannjjm 3810 22 - - HYPH cord-023095-4dannjjm 3810 23 value value NN cord-023095-4dannjjm 3810 24 o o CD cord-023095-4dannjjm 3810 25 0.05 0.05 CD cord-023095-4dannjjm 3810 26 ) ) -RRB- cord-023095-4dannjjm 3810 27 . . . cord-023095-4dannjjm 3811 1 One one CD cord-023095-4dannjjm 3811 2 - - HYPH cord-023095-4dannjjm 3811 3 hundred hundred CD cord-023095-4dannjjm 3811 4 and and CC cord-023095-4dannjjm 3811 5 eighteen eighteen CD cord-023095-4dannjjm 3811 6 owned own VBN cord-023095-4dannjjm 3811 7 dogs dog NNS cord-023095-4dannjjm 3811 8 from from IN cord-023095-4dannjjm 3811 9 Southeastern Southeastern NNP cord-023095-4dannjjm 3811 10 Spain Spain NNP cord-023095-4dannjjm 3811 11 presenting present VBG cord-023095-4dannjjm 3811 12 for for IN cord-023095-4dannjjm 3811 13 clinical clinical JJ cord-023095-4dannjjm 3811 14 evaluation evaluation NN cord-023095-4dannjjm 3811 15 were be VBD cord-023095-4dannjjm 3811 16 included include VBN cord-023095-4dannjjm 3811 17 in in IN cord-023095-4dannjjm 3811 18 the the DT cord-023095-4dannjjm 3811 19 study study NN cord-023095-4dannjjm 3811 20 . . . cord-023095-4dannjjm 3812 1 Criteria criterion NNS cord-023095-4dannjjm 3813 1 The the DT cord-023095-4dannjjm 3813 2 results result NNS cord-023095-4dannjjm 3813 3 of of IN cord-023095-4dannjjm 3813 4 this this DT cord-023095-4dannjjm 3813 5 study study NN cord-023095-4dannjjm 3813 6 highlight highlight VBP cord-023095-4dannjjm 3813 7 the the DT cord-023095-4dannjjm 3813 8 increased increase VBN cord-023095-4dannjjm 3813 9 sensitivity sensitivity NN cord-023095-4dannjjm 3813 10 of of IN cord-023095-4dannjjm 3813 11 PCR PCR NNP cord-023095-4dannjjm 3813 12 for for IN cord-023095-4dannjjm 3813 13 diagnosis diagnosis NN cord-023095-4dannjjm 3813 14 of of IN cord-023095-4dannjjm 3813 15 filariosis filariosis NN cord-023095-4dannjjm 3813 16 , , , cord-023095-4dannjjm 3813 17 confirm confirm VB cord-023095-4dannjjm 3813 18 the the DT cord-023095-4dannjjm 3813 19 presence presence NN cord-023095-4dannjjm 3813 20 of of IN cord-023095-4dannjjm 3813 21 Wolbachia Wolbachia NNP cord-023095-4dannjjm 3813 22 in in IN cord-023095-4dannjjm 3813 23 dogs dog NNS cord-023095-4dannjjm 3813 24 from from IN cord-023095-4dannjjm 3813 25 the the DT cord-023095-4dannjjm 3813 26 Mediterranean Mediterranean NNP cord-023095-4dannjjm 3813 27 basin basin NN cord-023095-4dannjjm 3813 28 , , , cord-023095-4dannjjm 3813 29 show show VB cord-023095-4dannjjm 3813 30 the the DT cord-023095-4dannjjm 3813 31 increased increase VBN cord-023095-4dannjjm 3813 32 severity severity NN cord-023095-4dannjjm 3813 33 of of IN cord-023095-4dannjjm 3813 34 HWD HWD NNP cord-023095-4dannjjm 3813 35 when when WRB cord-023095-4dannjjm 3813 36 Li Li NNP cord-023095-4dannjjm 3813 37 - - HYPH cord-023095-4dannjjm 3813 38 Filaria Filaria NNP cord-023095-4dannjjm 3813 39 coinfection coinfection NN cord-023095-4dannjjm 3813 40 is be VBZ cord-023095-4dannjjm 3813 41 present present JJ cord-023095-4dannjjm 3813 42 and and CC cord-023095-4dannjjm 3813 43 suggest suggest VBP cord-023095-4dannjjm 3813 44 that that IN cord-023095-4dannjjm 3813 45 Wolbachia Wolbachia NNP cord-023095-4dannjjm 3813 46 could could MD cord-023095-4dannjjm 3813 47 play play VB cord-023095-4dannjjm 3813 48 a a DT cord-023095-4dannjjm 3813 49 protective protective JJ cord-023095-4dannjjm 3813 50 role role NN cord-023095-4dannjjm 3813 51 for for IN cord-023095-4dannjjm 3813 52 leishmaniosis leishmaniosis NNP cord-023095-4dannjjm 3813 53 . . . cord-023095-4dannjjm 3814 1 Wolbachia Wolbachia NNP cord-023095-4dannjjm 3814 2 antigens antigen NNS cord-023095-4dannjjm 3814 3 can can MD cord-023095-4dannjjm 3814 4 stimulate stimulate VB cord-023095-4dannjjm 3814 5 a a DT cord-023095-4dannjjm 3814 6 Th1-type Th1-type NNP cord-023095-4dannjjm 3814 7 immune immune JJ cord-023095-4dannjjm 3814 8 response response NN cord-023095-4dannjjm 3814 9 , , , cord-023095-4dannjjm 3814 10 as as IN cord-023095-4dannjjm 3814 11 has have VBZ cord-023095-4dannjjm 3814 12 been be VBN cord-023095-4dannjjm 3814 13 previously previously RB cord-023095-4dannjjm 3814 14 described describe VBN cord-023095-4dannjjm 3814 15 . . . cord-023095-4dannjjm 3815 1 However however WRB cord-023095-4dannjjm 3815 2 other other JJ cord-023095-4dannjjm 3815 3 factors factor NNS cord-023095-4dannjjm 3815 4 ( ( -LRB- cord-023095-4dannjjm 3815 5 as as IN cord-023095-4dannjjm 3815 6 treatment treatment NN cord-023095-4dannjjm 3815 7 with with IN cord-023095-4dannjjm 3815 8 doxycicline doxycicline NNP cord-023095-4dannjjm 3815 9 ) ) -RRB- cord-023095-4dannjjm 3815 10 might may MD cord-023095-4dannjjm 3815 11 be be VB cord-023095-4dannjjm 3815 12 responsible responsible JJ cord-023095-4dannjjm 3815 13 for for IN cord-023095-4dannjjm 3815 14 the the DT cord-023095-4dannjjm 3815 15 lower low JJR cord-023095-4dannjjm 3815 16 prevalence prevalence NN cord-023095-4dannjjm 3815 17 of of IN cord-023095-4dannjjm 3815 18 Wolbachia Wolbachia NNP cord-023095-4dannjjm 3815 19 among among IN cord-023095-4dannjjm 3815 20 filaremic filaremic JJ cord-023095-4dannjjm 3815 21 dogs dog NNS cord-023095-4dannjjm 3815 22 infected infect VBN cord-023095-4dannjjm 3815 23 with with IN cord-023095-4dannjjm 3815 24 Li Li NNP cord-023095-4dannjjm 3815 25 and and CC cord-023095-4dannjjm 3815 26 further further JJ cord-023095-4dannjjm 3815 27 studies study NNS cord-023095-4dannjjm 3815 28 must must MD cord-023095-4dannjjm 3815 29 be be VB cord-023095-4dannjjm 3815 30 done do VBN cord-023095-4dannjjm 3815 31 to to TO cord-023095-4dannjjm 3815 32 clarify clarify VB cord-023095-4dannjjm 3815 33 this this DT cord-023095-4dannjjm 3815 34 interaction interaction NN cord-023095-4dannjjm 3815 35 . . . cord-023095-4dannjjm 3816 1 The the DT cord-023095-4dannjjm 3816 2 purpose purpose NN cord-023095-4dannjjm 3816 3 of of IN cord-023095-4dannjjm 3816 4 the the DT cord-023095-4dannjjm 3816 5 present present JJ cord-023095-4dannjjm 3816 6 study study NN cord-023095-4dannjjm 3816 7 was be VBD cord-023095-4dannjjm 3816 8 investigate investigate VB cord-023095-4dannjjm 3816 9 the the DT cord-023095-4dannjjm 3816 10 occurrence occurrence NN cord-023095-4dannjjm 3816 11 of of IN cord-023095-4dannjjm 3816 12 leishmaniasis leishmaniasis NN cord-023095-4dannjjm 3816 13 in in IN cord-023095-4dannjjm 3816 14 200 200 CD cord-023095-4dannjjm 3816 15 cats cat NNS cord-023095-4dannjjm 3816 16 in in IN cord-023095-4dannjjm 3816 17 the the DT cord-023095-4dannjjm 3816 18 municipality municipality NN cord-023095-4dannjjm 3816 19 of of IN cord-023095-4dannjjm 3816 20 Arac¸atuba Arac¸atuba NNP cord-023095-4dannjjm 3816 21 , , , cord-023095-4dannjjm 3816 22 Sa˜o Sa˜o NNP cord-023095-4dannjjm 3816 23 Paulo Paulo NNP cord-023095-4dannjjm 3816 24 , , , cord-023095-4dannjjm 3816 25 Brazil Brazil NNP cord-023095-4dannjjm 3816 26 , , , cord-023095-4dannjjm 3816 27 an an DT cord-023095-4dannjjm 3816 28 endemic endemic JJ cord-023095-4dannjjm 3816 29 area area NN cord-023095-4dannjjm 3816 30 for for IN cord-023095-4dannjjm 3816 31 canine canine JJ cord-023095-4dannjjm 3816 32 visceral visceral JJ cord-023095-4dannjjm 3816 33 leishmaniasis leishmaniasis NN cord-023095-4dannjjm 3816 34 . . . cord-023095-4dannjjm 3817 1 Animals animal NNS cord-023095-4dannjjm 3817 2 were be VBD cord-023095-4dannjjm 3817 3 evaluated evaluate VBN cord-023095-4dannjjm 3817 4 by by IN cord-023095-4dannjjm 3817 5 direct direct JJ cord-023095-4dannjjm 3817 6 parasitological parasitological JJ cord-023095-4dannjjm 3817 7 examination examination NN cord-023095-4dannjjm 3817 8 of of IN cord-023095-4dannjjm 3817 9 lymphoid lymphoid JJ cord-023095-4dannjjm 3817 10 organs organ NNS cord-023095-4dannjjm 3817 11 and and CC cord-023095-4dannjjm 3817 12 serology serology NN cord-023095-4dannjjm 3817 13 for for IN cord-023095-4dannjjm 3817 14 visceral visceral JJ cord-023095-4dannjjm 3817 15 leishmaniosis leishmaniosis NN cord-023095-4dannjjm 3817 16 by by IN cord-023095-4dannjjm 3817 17 immunosorbent immunosorbent JJ cord-023095-4dannjjm 3817 18 assay assay NN cord-023095-4dannjjm 3817 19 ( ( -LRB- cord-023095-4dannjjm 3817 20 ELISA ELISA NNP cord-023095-4dannjjm 3817 21 ) ) -RRB- cord-023095-4dannjjm 3817 22 and and CC cord-023095-4dannjjm 3817 23 indirect indirect JJ cord-023095-4dannjjm 3817 24 immunofluorescence immunofluorescence NN cord-023095-4dannjjm 3817 25 ( ( -LRB- cord-023095-4dannjjm 3817 26 IFAT IFAT NNP cord-023095-4dannjjm 3817 27 ) ) -RRB- cord-023095-4dannjjm 3817 28 . . . cord-023095-4dannjjm 3818 1 Thirteen thirteen CD cord-023095-4dannjjm 3818 2 ( ( -LRB- cord-023095-4dannjjm 3818 3 6.5 6.5 CD cord-023095-4dannjjm 3818 4 % % NN cord-023095-4dannjjm 3818 5 ) ) -RRB- cord-023095-4dannjjm 3818 6 out out IN cord-023095-4dannjjm 3818 7 of of IN cord-023095-4dannjjm 3818 8 200 200 CD cord-023095-4dannjjm 3818 9 cats cat NNS cord-023095-4dannjjm 3818 10 studied study VBN cord-023095-4dannjjm 3818 11 were be VBD cord-023095-4dannjjm 3818 12 diagnosed diagnose VBN cord-023095-4dannjjm 3818 13 with with IN cord-023095-4dannjjm 3818 14 visceral visceral JJ cord-023095-4dannjjm 3818 15 leishmaniasis leishmaniasis NN cord-023095-4dannjjm 3818 16 ; ; : cord-023095-4dannjjm 3818 17 eight eight CD cord-023095-4dannjjm 3818 18 ( ( -LRB- cord-023095-4dannjjm 3818 19 4 4 CD cord-023095-4dannjjm 3818 20 % % NN cord-023095-4dannjjm 3818 21 ) ) -RRB- cord-023095-4dannjjm 3818 22 by by IN cord-023095-4dannjjm 3818 23 parasitological parasitological NNP cord-023095-4dannjjm 3818 24 diagnosis diagnosis NN cord-023095-4dannjjm 3818 25 through through IN cord-023095-4dannjjm 3818 26 cytological cytological JJ cord-023095-4dannjjm 3818 27 examination examination NN cord-023095-4dannjjm 3818 28 of of IN cord-023095-4dannjjm 3818 29 lymphoid lymphoid JJ cord-023095-4dannjjm 3818 30 organs organ NNS cord-023095-4dannjjm 3818 31 , , , cord-023095-4dannjjm 3818 32 six six CD cord-023095-4dannjjm 3818 33 ( ( -LRB- cord-023095-4dannjjm 3818 34 3 3 CD cord-023095-4dannjjm 3818 35 % % NN cord-023095-4dannjjm 3818 36 ) ) -RRB- cord-023095-4dannjjm 3818 37 were be VBD cord-023095-4dannjjm 3818 38 considered consider VBN cord-023095-4dannjjm 3818 39 positive positive JJ cord-023095-4dannjjm 3818 40 by by IN cord-023095-4dannjjm 3818 41 ELISA ELISA NNP cord-023095-4dannjjm 3818 42 and and CC cord-023095-4dannjjm 3818 43 one one CD cord-023095-4dannjjm 3818 44 ( ( -LRB- cord-023095-4dannjjm 3818 45 0.5 0.5 CD cord-023095-4dannjjm 3818 46 % % NN cord-023095-4dannjjm 3818 47 ) ) -RRB- cord-023095-4dannjjm 3818 48 by by IN cord-023095-4dannjjm 3818 49 IFAT IFAT NNP cord-023095-4dannjjm 3818 50 . . . cord-023095-4dannjjm 3819 1 Only only RB cord-023095-4dannjjm 3819 2 two two CD cord-023095-4dannjjm 3819 3 ( ( -LRB- cord-023095-4dannjjm 3819 4 15.38 15.38 CD cord-023095-4dannjjm 3819 5 % % NN cord-023095-4dannjjm 3819 6 ) ) -RRB- cord-023095-4dannjjm 3819 7 out out IN cord-023095-4dannjjm 3819 8 of of IN cord-023095-4dannjjm 3819 9 the the DT cord-023095-4dannjjm 3819 10 thirteen thirteen CD cord-023095-4dannjjm 3819 11 infected infected JJ cord-023095-4dannjjm 3819 12 cats cat NNS cord-023095-4dannjjm 3819 13 had have VBD cord-023095-4dannjjm 3819 14 clinical clinical JJ cord-023095-4dannjjm 3819 15 signs sign NNS cord-023095-4dannjjm 3819 16 , , , cord-023095-4dannjjm 3819 17 characterized characterize VBN cord-023095-4dannjjm 3819 18 by by IN cord-023095-4dannjjm 3819 19 the the DT cord-023095-4dannjjm 3819 20 presence presence NN cord-023095-4dannjjm 3819 21 of of IN cord-023095-4dannjjm 3819 22 crusty crusty JJ cord-023095-4dannjjm 3819 23 lesions lesion NNS cord-023095-4dannjjm 3819 24 on on IN cord-023095-4dannjjm 3819 25 the the DT cord-023095-4dannjjm 3819 26 dorsal dorsal JJ cord-023095-4dannjjm 3819 27 cervical cervical JJ cord-023095-4dannjjm 3819 28 region region NN cord-023095-4dannjjm 3819 29 and and CC cord-023095-4dannjjm 3819 30 hepatosplenomegaly hepatosplenomegaly NNP cord-023095-4dannjjm 3819 31 . . . cord-023095-4dannjjm 3820 1 Regarding regard VBG cord-023095-4dannjjm 3820 2 age age NN cord-023095-4dannjjm 3820 3 five five CD cord-023095-4dannjjm 3820 4 cats cat NNS cord-023095-4dannjjm 3820 5 ( ( -LRB- cord-023095-4dannjjm 3820 6 38.5 38.5 CD cord-023095-4dannjjm 3820 7 % % NN cord-023095-4dannjjm 3820 8 ) ) -RRB- cord-023095-4dannjjm 3820 9 had have VBD cord-023095-4dannjjm 3820 10 between between IN cord-023095-4dannjjm 3820 11 six six CD cord-023095-4dannjjm 3820 12 months month NNS cord-023095-4dannjjm 3820 13 and and CC cord-023095-4dannjjm 3820 14 two two CD cord-023095-4dannjjm 3820 15 years year NNS cord-023095-4dannjjm 3820 16 , , , cord-023095-4dannjjm 3820 17 being be VBG cord-023095-4dannjjm 3820 18 the the DT cord-023095-4dannjjm 3820 19 others other NNS cord-023095-4dannjjm 3820 20 older old JJR cord-023095-4dannjjm 3820 21 than than IN cord-023095-4dannjjm 3820 22 2 2 CD cord-023095-4dannjjm 3820 23 years year NNS cord-023095-4dannjjm 3820 24 ( ( -LRB- cord-023095-4dannjjm 3820 25 61.5 61.5 CD cord-023095-4dannjjm 3820 26 % % NN cord-023095-4dannjjm 3820 27 ) ) -RRB- cord-023095-4dannjjm 3820 28 . . . cord-023095-4dannjjm 3821 1 Only only RB cord-023095-4dannjjm 3821 2 one one CD cord-023095-4dannjjm 3821 3 cat cat NN cord-023095-4dannjjm 3821 4 ( ( -LRB- cord-023095-4dannjjm 3821 5 7.7 7.7 CD cord-023095-4dannjjm 3821 6 % % NN cord-023095-4dannjjm 3821 7 ) ) -RRB- cord-023095-4dannjjm 3821 8 was be VBD cord-023095-4dannjjm 3821 9 positive positive JJ cord-023095-4dannjjm 3821 10 for for IN cord-023095-4dannjjm 3821 11 the the DT cord-023095-4dannjjm 3821 12 three three CD cord-023095-4dannjjm 3821 13 employed employ VBN cord-023095-4dannjjm 3821 14 methods method NNS cord-023095-4dannjjm 3821 15 . . . cord-023095-4dannjjm 3822 1 PCR PCR NNP cord-023095-4dannjjm 3822 2 confirmed confirm VBD cord-023095-4dannjjm 3822 3 Leishmania Leishmania NNP cord-023095-4dannjjm 3822 4 sp sp NN cord-023095-4dannjjm 3822 5 infection infection NN cord-023095-4dannjjm 3822 6 in in IN cord-023095-4dannjjm 3822 7 nine nine CD cord-023095-4dannjjm 3822 8 ( ( -LRB- cord-023095-4dannjjm 3822 9 69.2 69.2 CD cord-023095-4dannjjm 3822 10 % % NN cord-023095-4dannjjm 3822 11 ) ) -RRB- cord-023095-4dannjjm 3822 12 cats cat NNS cord-023095-4dannjjm 3822 13 , , , cord-023095-4dannjjm 3822 14 of of IN cord-023095-4dannjjm 3822 15 which which WDT cord-023095-4dannjjm 3822 16 six six CD cord-023095-4dannjjm 3822 17 were be VBD cord-023095-4dannjjm 3822 18 diagnosed diagnose VBN cord-023095-4dannjjm 3822 19 previously previously RB cord-023095-4dannjjm 3822 20 by by IN cord-023095-4dannjjm 3822 21 cytological cytological JJ cord-023095-4dannjjm 3822 22 examination examination NN cord-023095-4dannjjm 3822 23 , , , cord-023095-4dannjjm 3822 24 two two CD cord-023095-4dannjjm 3822 25 by by IN cord-023095-4dannjjm 3822 26 ELISA ELISA NNP cord-023095-4dannjjm 3822 27 and and CC cord-023095-4dannjjm 3822 28 one one CD cord-023095-4dannjjm 3822 29 by by IN cord-023095-4dannjjm 3822 30 the the DT cord-023095-4dannjjm 3822 31 three three CD cord-023095-4dannjjm 3822 32 techniques technique NNS cord-023095-4dannjjm 3822 33 employed employ VBN cord-023095-4dannjjm 3822 34 . . . cord-023095-4dannjjm 3823 1 Since since IN cord-023095-4dannjjm 3823 2 its -PRON- PRP$ cord-023095-4dannjjm 3823 3 first first JJ cord-023095-4dannjjm 3823 4 description description NN cord-023095-4dannjjm 3823 5 in in IN cord-023095-4dannjjm 3823 6 1912 1912 CD cord-023095-4dannjjm 3823 7 feline feline JJ cord-023095-4dannjjm 3823 8 leishmaniosis leishmaniosis NNP cord-023095-4dannjjm 3823 9 has have VBZ cord-023095-4dannjjm 3823 10 been be VBN cord-023095-4dannjjm 3823 11 reported report VBN cord-023095-4dannjjm 3823 12 in in IN cord-023095-4dannjjm 3823 13 several several JJ cord-023095-4dannjjm 3823 14 countries country NNS cord-023095-4dannjjm 3823 15 . . . cord-023095-4dannjjm 3824 1 The the DT cord-023095-4dannjjm 3824 2 purpose purpose NN cord-023095-4dannjjm 3824 3 of of IN cord-023095-4dannjjm 3824 4 this this DT cord-023095-4dannjjm 3824 5 study study NN cord-023095-4dannjjm 3824 6 was be VBD cord-023095-4dannjjm 3824 7 to to TO cord-023095-4dannjjm 3824 8 assess assess VB cord-023095-4dannjjm 3824 9 the the DT cord-023095-4dannjjm 3824 10 prevalence prevalence NN cord-023095-4dannjjm 3824 11 of of IN cord-023095-4dannjjm 3824 12 Leishmania Leishmania NNP cord-023095-4dannjjm 3824 13 chagasi chagasi NN cord-023095-4dannjjm 3824 14 infection infection NN cord-023095-4dannjjm 3824 15 in in IN cord-023095-4dannjjm 3824 16 cats cat NNS cord-023095-4dannjjm 3824 17 showing show VBG cord-023095-4dannjjm 3824 18 dermatologic dermatologic JJ cord-023095-4dannjjm 3824 19 lesions lesion NNS cord-023095-4dannjjm 3824 20 from from IN cord-023095-4dannjjm 3824 21 an an DT cord-023095-4dannjjm 3824 22 endemic endemic JJ cord-023095-4dannjjm 3824 23 area area NN cord-023095-4dannjjm 3824 24 for for IN cord-023095-4dannjjm 3824 25 visceral visceral JJ cord-023095-4dannjjm 3824 26 leishmaniasis leishmaniasis NN cord-023095-4dannjjm 3824 27 in in IN cord-023095-4dannjjm 3824 28 Brazil Brazil NNP cord-023095-4dannjjm 3824 29 . . . cord-023095-4dannjjm 3825 1 Animals animal NNS cord-023095-4dannjjm 3825 2 were be VBD cord-023095-4dannjjm 3825 3 evaluated evaluate VBN cord-023095-4dannjjm 3825 4 by by IN cord-023095-4dannjjm 3825 5 direct direct JJ cord-023095-4dannjjm 3825 6 parasitological parasitological JJ cord-023095-4dannjjm 3825 7 examination examination NN cord-023095-4dannjjm 3825 8 of of IN cord-023095-4dannjjm 3825 9 lymphoid lymphoid JJ cord-023095-4dannjjm 3825 10 organs organ NNS cord-023095-4dannjjm 3825 11 , , , cord-023095-4dannjjm 3825 12 immunohistochemical immunohistochemical JJ cord-023095-4dannjjm 3825 13 technique technique NN cord-023095-4dannjjm 3825 14 for for IN cord-023095-4dannjjm 3825 15 detection detection NN cord-023095-4dannjjm 3825 16 of of IN cord-023095-4dannjjm 3825 17 amastigotes amastigote NNS cord-023095-4dannjjm 3825 18 in in IN cord-023095-4dannjjm 3825 19 lesioned lesioned JJ cord-023095-4dannjjm 3825 20 skin skin NN cord-023095-4dannjjm 3825 21 and and CC cord-023095-4dannjjm 3825 22 serology serology NN cord-023095-4dannjjm 3825 23 for for IN cord-023095-4dannjjm 3825 24 visceral visceral JJ cord-023095-4dannjjm 3825 25 leishmaniosis leishmaniosis NN cord-023095-4dannjjm 3825 26 by by IN cord-023095-4dannjjm 3825 27 immunosorbent immunosorbent JJ cord-023095-4dannjjm 3825 28 assay assay NN cord-023095-4dannjjm 3825 29 ( ( -LRB- cord-023095-4dannjjm 3825 30 ELISA ELISA NNP cord-023095-4dannjjm 3825 31 ) ) -RRB- cord-023095-4dannjjm 3825 32 and and CC cord-023095-4dannjjm 3825 33 indirect indirect JJ cord-023095-4dannjjm 3825 34 immunofluorescence immunofluorescence NN cord-023095-4dannjjm 3825 35 ( ( -LRB- cord-023095-4dannjjm 3825 36 IFAT IFAT NNP cord-023095-4dannjjm 3825 37 ) ) -RRB- cord-023095-4dannjjm 3825 38 . . . cord-023095-4dannjjm 3826 1 Twenty twenty CD cord-023095-4dannjjm 3826 2 seven seven CD cord-023095-4dannjjm 3826 3 ( ( -LRB- cord-023095-4dannjjm 3826 4 49.1 49.1 CD cord-023095-4dannjjm 3826 5 % % NN cord-023095-4dannjjm 3826 6 ) ) -RRB- cord-023095-4dannjjm 3826 7 out out IN cord-023095-4dannjjm 3826 8 of of IN cord-023095-4dannjjm 3826 9 the the DT cord-023095-4dannjjm 3826 10 55 55 CD cord-023095-4dannjjm 3826 11 cats cat NNS cord-023095-4dannjjm 3826 12 studied study VBN cord-023095-4dannjjm 3826 13 were be VBD cord-023095-4dannjjm 3826 14 diagnosed diagnose VBN cord-023095-4dannjjm 3826 15 with with IN cord-023095-4dannjjm 3826 16 visceral visceral JJ cord-023095-4dannjjm 3826 17 leishmaniosis leishmaniosis NN cord-023095-4dannjjm 3826 18 . . . cord-023095-4dannjjm 3827 1 Twelve twelve CD cord-023095-4dannjjm 3827 2 ( ( -LRB- cord-023095-4dannjjm 3827 3 44.4 44.4 CD cord-023095-4dannjjm 3827 4 % % NN cord-023095-4dannjjm 3827 5 ) ) -RRB- cord-023095-4dannjjm 3827 6 were be VBD cord-023095-4dannjjm 3827 7 positive positive JJ cord-023095-4dannjjm 3827 8 by by IN cord-023095-4dannjjm 3827 9 parasitological parasitological JJ cord-023095-4dannjjm 3827 10 diagnosis diagnosis NN cord-023095-4dannjjm 3827 11 ; ; : cord-023095-4dannjjm 3827 12 amastigote amastigote NN cord-023095-4dannjjm 3827 13 forms form NNS cord-023095-4dannjjm 3827 14 of of IN cord-023095-4dannjjm 3827 15 Leishmania Leishmania NNP cord-023095-4dannjjm 3827 16 sp sp NNP cord-023095-4dannjjm 3827 17 were be VBD cord-023095-4dannjjm 3827 18 identified identify VBN cord-023095-4dannjjm 3827 19 in in IN cord-023095-4dannjjm 3827 20 lymphoid lymphoid JJ cord-023095-4dannjjm 3827 21 organs organ NNS cord-023095-4dannjjm 3827 22 from from IN cord-023095-4dannjjm 3827 23 10/55 10/55 CD cord-023095-4dannjjm 3827 24 ( ( -LRB- cord-023095-4dannjjm 3827 25 18.2 18.2 CD cord-023095-4dannjjm 3827 26 % % NN cord-023095-4dannjjm 3827 27 ) ) -RRB- cord-023095-4dannjjm 3827 28 infected infect VBN cord-023095-4dannjjm 3827 29 cats cat NNS cord-023095-4dannjjm 3827 30 , , , cord-023095-4dannjjm 3827 31 and and CC cord-023095-4dannjjm 3827 32 immunohistochemical immunohistochemical JJ cord-023095-4dannjjm 3827 33 technique technique NN cord-023095-4dannjjm 3827 34 allowed allow VBD cord-023095-4dannjjm 3827 35 the the DT cord-023095-4dannjjm 3827 36 identification identification NN cord-023095-4dannjjm 3827 37 of of IN cord-023095-4dannjjm 3827 38 nine nine CD cord-023095-4dannjjm 3827 39 ( ( -LRB- cord-023095-4dannjjm 3827 40 16.4 16.4 CD cord-023095-4dannjjm 3827 41 % % NN cord-023095-4dannjjm 3827 42 ) ) -RRB- cord-023095-4dannjjm 3827 43 positive positive JJ cord-023095-4dannjjm 3827 44 animals animal NNS cord-023095-4dannjjm 3827 45 . . . cord-023095-4dannjjm 3828 1 The the DT cord-023095-4dannjjm 3828 2 seroprevalence seroprevalence NN cord-023095-4dannjjm 3828 3 of of IN cord-023095-4dannjjm 3828 4 leishmaniosis leishmaniosis NNP cord-023095-4dannjjm 3828 5 was be VBD cord-023095-4dannjjm 3828 6 25.4 25.4 CD cord-023095-4dannjjm 3828 7 % % NN cord-023095-4dannjjm 3828 8 ( ( -LRB- cord-023095-4dannjjm 3828 9 14/55 14/55 CD cord-023095-4dannjjm 3828 10 ) ) -RRB- cord-023095-4dannjjm 3828 11 by by IN cord-023095-4dannjjm 3828 12 ELISA ELISA NNP cord-023095-4dannjjm 3828 13 and and CC cord-023095-4dannjjm 3828 14 10.9 10.9 CD cord-023095-4dannjjm 3828 15 % % NN cord-023095-4dannjjm 3828 16 ( ( -LRB- cord-023095-4dannjjm 3828 17 6/55 6/55 CD cord-023095-4dannjjm 3828 18 ) ) -RRB- cord-023095-4dannjjm 3828 19 by by IN cord-023095-4dannjjm 3828 20 IFAT IFAT NNP cord-023095-4dannjjm 3828 21 . . . cord-023095-4dannjjm 3829 1 FIV FIV NNP cord-023095-4dannjjm 3829 2 specific specific JJ cord-023095-4dannjjm 3829 3 antibodies antibody NNS cord-023095-4dannjjm 3829 4 were be VBD cord-023095-4dannjjm 3829 5 found find VBN cord-023095-4dannjjm 3829 6 in in IN cord-023095-4dannjjm 3829 7 6/55 6/55 CD cord-023095-4dannjjm 3829 8 cats cat NNS cord-023095-4dannjjm 3829 9 ( ( -LRB- cord-023095-4dannjjm 3829 10 10.9 10.9 CD cord-023095-4dannjjm 3829 11 % % NN cord-023095-4dannjjm 3829 12 ) ) -RRB- cord-023095-4dannjjm 3829 13 , , , cord-023095-4dannjjm 3829 14 of of IN cord-023095-4dannjjm 3829 15 which which WDT cord-023095-4dannjjm 3829 16 5/6 5/6 CD cord-023095-4dannjjm 3829 17 ( ( -LRB- cord-023095-4dannjjm 3829 18 83.3 83.3 CD cord-023095-4dannjjm 3829 19 % % NN cord-023095-4dannjjm 3829 20 ) ) -RRB- cord-023095-4dannjjm 3829 21 had have VBD cord-023095-4dannjjm 3829 22 leishmaniosis leishmaniosi NNS cord-023095-4dannjjm 3829 23 . . . cord-023095-4dannjjm 3830 1 Real real JJ cord-023095-4dannjjm 3830 2 time time NN cord-023095-4dannjjm 3830 3 PCR PCR NNP cord-023095-4dannjjm 3830 4 confirmed confirm VBD cord-023095-4dannjjm 3830 5 Leishmania Leishmania NNP cord-023095-4dannjjm 3830 6 chagasi chagasi NN cord-023095-4dannjjm 3830 7 infection infection NN cord-023095-4dannjjm 3830 8 in in IN cord-023095-4dannjjm 3830 9 three three CD cord-023095-4dannjjm 3830 10 cats cat NNS cord-023095-4dannjjm 3830 11 . . . cord-023095-4dannjjm 3831 1 Based base VBN cord-023095-4dannjjm 3831 2 on on IN cord-023095-4dannjjm 3831 3 the the DT cord-023095-4dannjjm 3831 4 evidence evidence NN cord-023095-4dannjjm 3831 5 of of IN cord-023095-4dannjjm 3831 6 the the DT cord-023095-4dannjjm 3831 7 high high JJ cord-023095-4dannjjm 3831 8 occurrence occurrence NN cord-023095-4dannjjm 3831 9 of of IN cord-023095-4dannjjm 3831 10 leishmaniosis leishmaniosis NN cord-023095-4dannjjm 3831 11 in in IN cord-023095-4dannjjm 3831 12 cats cat NNS cord-023095-4dannjjm 3831 13 in in IN cord-023095-4dannjjm 3831 14 this this DT cord-023095-4dannjjm 3831 15 study study NN cord-023095-4dannjjm 3831 16 , , , cord-023095-4dannjjm 3831 17 this this DT cord-023095-4dannjjm 3831 18 disease disease NN cord-023095-4dannjjm 3831 19 should should MD cord-023095-4dannjjm 3831 20 be be VB cord-023095-4dannjjm 3831 21 included include VBN cord-023095-4dannjjm 3831 22 in in IN cord-023095-4dannjjm 3831 23 the the DT cord-023095-4dannjjm 3831 24 differential differential JJ cord-023095-4dannjjm 3831 25 diagnosis diagnosis NN cord-023095-4dannjjm 3831 26 of of IN cord-023095-4dannjjm 3831 27 skin skin NN cord-023095-4dannjjm 3831 28 diseases disease NNS cord-023095-4dannjjm 3831 29 of of IN cord-023095-4dannjjm 3831 30 felines feline NNS cord-023095-4dannjjm 3831 31 living live VBG cord-023095-4dannjjm 3831 32 in in IN cord-023095-4dannjjm 3831 33 endemic endemic JJ cord-023095-4dannjjm 3831 34 areas area NNS cord-023095-4dannjjm 3831 35 . . . cord-023095-4dannjjm 3832 1 Blastomyces Blastomyces NNP cord-023095-4dannjjm 3832 2 dermatiditis dermatiditis NN cord-023095-4dannjjm 3832 3 is be VBZ cord-023095-4dannjjm 3832 4 a a DT cord-023095-4dannjjm 3832 5 dimorphic dimorphic JJ cord-023095-4dannjjm 3832 6 fungus fungus NN cord-023095-4dannjjm 3832 7 that that WDT cord-023095-4dannjjm 3832 8 commonly commonly RB cord-023095-4dannjjm 3832 9 affects affect VBZ cord-023095-4dannjjm 3832 10 large large JJ cord-023095-4dannjjm 3832 11 - - HYPH cord-023095-4dannjjm 3832 12 breed breed NN cord-023095-4dannjjm 3832 13 hunting hunting NN cord-023095-4dannjjm 3832 14 dogs dog NNS cord-023095-4dannjjm 3832 15 . . . cord-023095-4dannjjm 3833 1 A a DT cord-023095-4dannjjm 3833 2 recent recent JJ cord-023095-4dannjjm 3833 3 advancement advancement NN cord-023095-4dannjjm 3833 4 in in IN cord-023095-4dannjjm 3833 5 diagnosis diagnosis NN cord-023095-4dannjjm 3833 6 has have VBZ cord-023095-4dannjjm 3833 7 come come VBN cord-023095-4dannjjm 3833 8 with with IN cord-023095-4dannjjm 3833 9 the the DT cord-023095-4dannjjm 3833 10 advent advent NN cord-023095-4dannjjm 3833 11 of of IN cord-023095-4dannjjm 3833 12 a a DT cord-023095-4dannjjm 3833 13 urine urine NN cord-023095-4dannjjm 3833 14 antigen antigen NN cord-023095-4dannjjm 3833 15 screening screening NN cord-023095-4dannjjm 3833 16 test test NN cord-023095-4dannjjm 3833 17 that that WDT cord-023095-4dannjjm 3833 18 has have VBZ cord-023095-4dannjjm 3833 19 both both DT cord-023095-4dannjjm 3833 20 high high JJ cord-023095-4dannjjm 3833 21 sensitivity sensitivity NN cord-023095-4dannjjm 3833 22 and and CC cord-023095-4dannjjm 3833 23 moderately moderately RB cord-023095-4dannjjm 3833 24 high high JJ cord-023095-4dannjjm 3833 25 specificity specificity NN cord-023095-4dannjjm 3833 26 . . . cord-023095-4dannjjm 3834 1 Therapy therapy NN cord-023095-4dannjjm 3834 2 for for IN cord-023095-4dannjjm 3834 3 the the DT cord-023095-4dannjjm 3834 4 disease disease NN cord-023095-4dannjjm 3834 5 involves involve VBZ cord-023095-4dannjjm 3834 6 use use NN cord-023095-4dannjjm 3834 7 of of IN cord-023095-4dannjjm 3834 8 antifungal antifungal JJ cord-023095-4dannjjm 3834 9 agents agent NNS cord-023095-4dannjjm 3834 10 , , , cord-023095-4dannjjm 3834 11 usually usually RB cord-023095-4dannjjm 3834 12 itraconazole itraconazole NNP cord-023095-4dannjjm 3834 13 , , , cord-023095-4dannjjm 3834 14 and and CC cord-023095-4dannjjm 3834 15 length length NN cord-023095-4dannjjm 3834 16 of of IN cord-023095-4dannjjm 3834 17 treatment treatment NN cord-023095-4dannjjm 3834 18 is be VBZ cord-023095-4dannjjm 3834 19 based base VBN cord-023095-4dannjjm 3834 20 chiefly chiefly RB cord-023095-4dannjjm 3834 21 on on IN cord-023095-4dannjjm 3834 22 resolution resolution NN cord-023095-4dannjjm 3834 23 of of IN cord-023095-4dannjjm 3834 24 clinical clinical JJ cord-023095-4dannjjm 3834 25 and and CC cord-023095-4dannjjm 3834 26 radiologic radiologic JJ cord-023095-4dannjjm 3834 27 signs sign NNS cord-023095-4dannjjm 3834 28 . . . cord-023095-4dannjjm 3835 1 With with IN cord-023095-4dannjjm 3835 2 the the DT cord-023095-4dannjjm 3835 3 new new JJ cord-023095-4dannjjm 3835 4 urine urine NN cord-023095-4dannjjm 3835 5 antigen antigen NN cord-023095-4dannjjm 3835 6 test test NN cord-023095-4dannjjm 3835 7 , , , cord-023095-4dannjjm 3835 8 however however RB cord-023095-4dannjjm 3835 9 , , , cord-023095-4dannjjm 3835 10 a a DT cord-023095-4dannjjm 3835 11 noninvasive noninvasive JJ cord-023095-4dannjjm 3835 12 route route NN cord-023095-4dannjjm 3835 13 of of IN cord-023095-4dannjjm 3835 14 monitoring monitor VBG cord-023095-4dannjjm 3835 15 treatment treatment NN cord-023095-4dannjjm 3835 16 progress progress NN cord-023095-4dannjjm 3835 17 is be VBZ cord-023095-4dannjjm 3835 18 available available JJ cord-023095-4dannjjm 3835 19 and and CC cord-023095-4dannjjm 3835 20 could could MD cord-023095-4dannjjm 3835 21 be be VB cord-023095-4dannjjm 3835 22 an an DT cord-023095-4dannjjm 3835 23 adjunct adjunct JJ cord-023095-4dannjjm 3835 24 device device NN cord-023095-4dannjjm 3835 25 utilized utilize VBN cord-023095-4dannjjm 3835 26 to to TO cord-023095-4dannjjm 3835 27 determine determine VB cord-023095-4dannjjm 3835 28 treatment treatment NN cord-023095-4dannjjm 3835 29 efficacy efficacy NN cord-023095-4dannjjm 3835 30 and and CC cord-023095-4dannjjm 3835 31 may may MD cord-023095-4dannjjm 3835 32 even even RB cord-023095-4dannjjm 3835 33 reveal reveal VB cord-023095-4dannjjm 3835 34 a a DT cord-023095-4dannjjm 3835 35 need need NN cord-023095-4dannjjm 3835 36 for for IN cord-023095-4dannjjm 3835 37 prolonged prolong VBN cord-023095-4dannjjm 3835 38 treatment treatment NN cord-023095-4dannjjm 3835 39 . . . cord-023095-4dannjjm 3836 1 Therefore therefore RB cord-023095-4dannjjm 3836 2 , , , cord-023095-4dannjjm 3836 3 the the DT cord-023095-4dannjjm 3836 4 purpose purpose NN cord-023095-4dannjjm 3836 5 of of IN cord-023095-4dannjjm 3836 6 this this DT cord-023095-4dannjjm 3836 7 study study NN cord-023095-4dannjjm 3836 8 was be VBD cord-023095-4dannjjm 3836 9 to to TO cord-023095-4dannjjm 3836 10 determine determine VB cord-023095-4dannjjm 3836 11 if if IN cord-023095-4dannjjm 3836 12 monitoring monitor VBG cord-023095-4dannjjm 3836 13 the the DT cord-023095-4dannjjm 3836 14 Blastomyces Blastomyces NNP cord-023095-4dannjjm 3836 15 urine urine NN cord-023095-4dannjjm 3836 16 antigen antigen NN cord-023095-4dannjjm 3836 17 test test NN cord-023095-4dannjjm 3836 18 and and CC cord-023095-4dannjjm 3836 19 comparing compare VBG cord-023095-4dannjjm 3836 20 to to IN cord-023095-4dannjjm 3836 21 pulmonary pulmonary JJ cord-023095-4dannjjm 3836 22 radiographic radiographic JJ cord-023095-4dannjjm 3836 23 signs sign NNS cord-023095-4dannjjm 3836 24 would would MD cord-023095-4dannjjm 3836 25 elucidate elucidate VB cord-023095-4dannjjm 3836 26 the the DT cord-023095-4dannjjm 3836 27 necessity necessity NN cord-023095-4dannjjm 3836 28 for for IN cord-023095-4dannjjm 3836 29 prolonged prolong VBN cord-023095-4dannjjm 3836 30 antifungal antifungal NN cord-023095-4dannjjm 3836 31 therapy therapy NN cord-023095-4dannjjm 3836 32 , , , cord-023095-4dannjjm 3836 33 even even RB cord-023095-4dannjjm 3836 34 after after IN cord-023095-4dannjjm 3836 35 resolution resolution NN cord-023095-4dannjjm 3836 36 of of IN cord-023095-4dannjjm 3836 37 radiologic radiologic JJ cord-023095-4dannjjm 3836 38 signs sign NNS cord-023095-4dannjjm 3836 39 . . . cord-023095-4dannjjm 3837 1 To to IN cord-023095-4dannjjm 3837 2 this this DT cord-023095-4dannjjm 3837 3 end end NN cord-023095-4dannjjm 3837 4 , , , cord-023095-4dannjjm 3837 5 a a DT cord-023095-4dannjjm 3837 6 retrospective retrospective JJ cord-023095-4dannjjm 3837 7 case case NN cord-023095-4dannjjm 3837 8 review review NN cord-023095-4dannjjm 3837 9 was be VBD cord-023095-4dannjjm 3837 10 performed perform VBN cord-023095-4dannjjm 3837 11 that that WDT cord-023095-4dannjjm 3837 12 identified identify VBD cord-023095-4dannjjm 3837 13 a a DT cord-023095-4dannjjm 3837 14 series series NN cord-023095-4dannjjm 3837 15 of of IN cord-023095-4dannjjm 3837 16 client client NN cord-023095-4dannjjm 3837 17 - - HYPH cord-023095-4dannjjm 3837 18 owned own VBN cord-023095-4dannjjm 3837 19 animals animal NNS cord-023095-4dannjjm 3837 20 with with IN cord-023095-4dannjjm 3837 21 naturally naturally RB cord-023095-4dannjjm 3837 22 occurring occur VBG cord-023095-4dannjjm 3837 23 blastomycosis blastomycosis NN cord-023095-4dannjjm 3837 24 . . . cord-023095-4dannjjm 3838 1 The the DT cord-023095-4dannjjm 3838 2 inclusion inclusion NN cord-023095-4dannjjm 3838 3 criteria criterion NNS cord-023095-4dannjjm 3838 4 were be VBD cord-023095-4dannjjm 3838 5 radiographic radiographic JJ cord-023095-4dannjjm 3838 6 pulmonary pulmonary JJ cord-023095-4dannjjm 3838 7 parenchymal parenchymal NN cord-023095-4dannjjm 3838 8 signs sign NNS cord-023095-4dannjjm 3838 9 consistent consistent JJ cord-023095-4dannjjm 3838 10 with with IN cord-023095-4dannjjm 3838 11 fungal fungal JJ cord-023095-4dannjjm 3838 12 disease disease NN cord-023095-4dannjjm 3838 13 and and CC cord-023095-4dannjjm 3838 14 urine urine NN cord-023095-4dannjjm 3838 15 antigenconfirmed antigenconfirme VBN cord-023095-4dannjjm 3838 16 blastomycosis blastomycosis NN cord-023095-4dannjjm 3838 17 with with IN cord-023095-4dannjjm 3838 18 repeated repeat VBN cord-023095-4dannjjm 3838 19 testing testing NN cord-023095-4dannjjm 3838 20 of of IN cord-023095-4dannjjm 3838 21 both both DT cord-023095-4dannjjm 3838 22 radiographs radiograph NNS cord-023095-4dannjjm 3838 23 and and CC cord-023095-4dannjjm 3838 24 urine urine NN cord-023095-4dannjjm 3838 25 antigen antigen NN cord-023095-4dannjjm 3838 26 quantification quantification NN cord-023095-4dannjjm 3838 27 as as IN cord-023095-4dannjjm 3838 28 monitoring monitoring NN cord-023095-4dannjjm 3838 29 parameters parameter NNS cord-023095-4dannjjm 3838 30 until until IN cord-023095-4dannjjm 3838 31 negative negative JJ cord-023095-4dannjjm 3838 32 results result NNS cord-023095-4dannjjm 3838 33 achieved achieve VBN cord-023095-4dannjjm 3838 34 in in IN cord-023095-4dannjjm 3838 35 each each DT cord-023095-4dannjjm 3838 36 . . . cord-023095-4dannjjm 3839 1 Ideally ideally RB cord-023095-4dannjjm 3839 2 , , , cord-023095-4dannjjm 3839 3 intervals interval NNS cord-023095-4dannjjm 3839 4 between between IN cord-023095-4dannjjm 3839 5 testing testing NN cord-023095-4dannjjm 3839 6 dates date NNS cord-023095-4dannjjm 3839 7 would would MD cord-023095-4dannjjm 3839 8 be be VB cord-023095-4dannjjm 3839 9 between between IN cord-023095-4dannjjm 3839 10 two two CD cord-023095-4dannjjm 3839 11 and and CC cord-023095-4dannjjm 3839 12 five five CD cord-023095-4dannjjm 3839 13 months month NNS cord-023095-4dannjjm 3839 14 . . . cord-023095-4dannjjm 3840 1 Radiographs radiograph NNS cord-023095-4dannjjm 3840 2 were be VBD cord-023095-4dannjjm 3840 3 considered consider VBN cord-023095-4dannjjm 3840 4 negative negative JJ cord-023095-4dannjjm 3840 5 if if IN cord-023095-4dannjjm 3840 6 all all DT cord-023095-4dannjjm 3840 7 radiographic radiographic JJ cord-023095-4dannjjm 3840 8 changes change NNS cord-023095-4dannjjm 3840 9 had have VBD cord-023095-4dannjjm 3840 10 resolved resolve VBN cord-023095-4dannjjm 3840 11 or or CC cord-023095-4dannjjm 3840 12 if if IN cord-023095-4dannjjm 3840 13 repeated repeat VBN cord-023095-4dannjjm 3840 14 radiographs radiograph NNS cord-023095-4dannjjm 3840 15 separated separate VBN cord-023095-4dannjjm 3840 16 by by IN cord-023095-4dannjjm 3840 17 at at RB cord-023095-4dannjjm 3840 18 least least RBS cord-023095-4dannjjm 3840 19 one one CD cord-023095-4dannjjm 3840 20 month month NN cord-023095-4dannjjm 3840 21 were be VBD cord-023095-4dannjjm 3840 22 considered consider VBN cord-023095-4dannjjm 3840 23 static static JJ cord-023095-4dannjjm 3840 24 after after IN cord-023095-4dannjjm 3840 25 documented document VBN cord-023095-4dannjjm 3840 26 improvement improvement NN cord-023095-4dannjjm 3840 27 had have VBD cord-023095-4dannjjm 3840 28 occurred occur VBN cord-023095-4dannjjm 3840 29 from from IN cord-023095-4dannjjm 3840 30 original original JJ cord-023095-4dannjjm 3840 31 diagnostic diagnostic JJ cord-023095-4dannjjm 3840 32 radiographs radiograph NNS cord-023095-4dannjjm 3840 33 ( ( -LRB- cord-023095-4dannjjm 3840 34 suspected suspect VBN cord-023095-4dannjjm 3840 35 scarring scarring NN cord-023095-4dannjjm 3840 36 ) ) -RRB- cord-023095-4dannjjm 3840 37 . . . cord-023095-4dannjjm 3841 1 Urine urine NN cord-023095-4dannjjm 3841 2 antigen antigen NN cord-023095-4dannjjm 3841 3 testing testing NN cord-023095-4dannjjm 3841 4 was be VBD cord-023095-4dannjjm 3841 5 considered consider VBN cord-023095-4dannjjm 3841 6 negative negative JJ cord-023095-4dannjjm 3841 7 if if IN cord-023095-4dannjjm 3841 8 concentrations concentration NNS cord-023095-4dannjjm 3841 9 were be VBD cord-023095-4dannjjm 3841 10 less less JJR cord-023095-4dannjjm 3841 11 than than IN cord-023095-4dannjjm 3841 12 1.0 1.0 CD cord-023095-4dannjjm 3841 13 enzyme enzyme NN cord-023095-4dannjjm 3841 14 immunoassay immunoassay NN cord-023095-4dannjjm 3841 15 units unit NNS cord-023095-4dannjjm 3841 16 , , , cord-023095-4dannjjm 3841 17 a a DT cord-023095-4dannjjm 3841 18 reference reference NN cord-023095-4dannjjm 3841 19 interval interval NN cord-023095-4dannjjm 3841 20 set set VBN cord-023095-4dannjjm 3841 21 by by IN cord-023095-4dannjjm 3841 22 the the DT cord-023095-4dannjjm 3841 23 testing testing NN cord-023095-4dannjjm 3841 24 laboratory laboratory NN cord-023095-4dannjjm 3841 25 . . . cord-023095-4dannjjm 3842 1 Preliminary preliminary JJ cord-023095-4dannjjm 3842 2 data data NN cord-023095-4dannjjm 3842 3 analysis analysis NN cord-023095-4dannjjm 3842 4 reveals reveal VBZ cord-023095-4dannjjm 3842 5 resolution resolution NN cord-023095-4dannjjm 3842 6 of of IN cord-023095-4dannjjm 3842 7 radiographic radiographic JJ cord-023095-4dannjjm 3842 8 signs sign NNS cord-023095-4dannjjm 3842 9 of of IN cord-023095-4dannjjm 3842 10 blastomycosis blastomycosis NN cord-023095-4dannjjm 3842 11 occurred occur VBD cord-023095-4dannjjm 3842 12 earlier early RBR cord-023095-4dannjjm 3842 13 in in IN cord-023095-4dannjjm 3842 14 many many JJ cord-023095-4dannjjm 3842 15 of of IN cord-023095-4dannjjm 3842 16 the the DT cord-023095-4dannjjm 3842 17 cases case NNS cord-023095-4dannjjm 3842 18 presented present VBN cord-023095-4dannjjm 3842 19 than than IN cord-023095-4dannjjm 3842 20 did do VBD cord-023095-4dannjjm 3842 21 attaining attain VBG cord-023095-4dannjjm 3842 22 a a DT cord-023095-4dannjjm 3842 23 negative negative JJ cord-023095-4dannjjm 3842 24 urine urine NN cord-023095-4dannjjm 3842 25 antigen antigen NN cord-023095-4dannjjm 3842 26 concentration concentration NN cord-023095-4dannjjm 3842 27 . . . cord-023095-4dannjjm 3843 1 Ceasing cease VBG cord-023095-4dannjjm 3843 2 treatment treatment NN cord-023095-4dannjjm 3843 3 1 1 CD cord-023095-4dannjjm 3843 4 month month NN cord-023095-4dannjjm 3843 5 after after IN cord-023095-4dannjjm 3843 6 radiographic radiographic JJ cord-023095-4dannjjm 3843 7 resolution resolution NN cord-023095-4dannjjm 3843 8 of of IN cord-023095-4dannjjm 3843 9 signs sign NNS cord-023095-4dannjjm 3843 10 as as IN cord-023095-4dannjjm 3843 11 has have VBZ cord-023095-4dannjjm 3843 12 been be VBN cord-023095-4dannjjm 3843 13 recommended recommend VBN cord-023095-4dannjjm 3843 14 in in IN cord-023095-4dannjjm 3843 15 the the DT cord-023095-4dannjjm 3843 16 past past NN cord-023095-4dannjjm 3843 17 might may MD cord-023095-4dannjjm 3843 18 have have VB cord-023095-4dannjjm 3843 19 resulted result VBN cord-023095-4dannjjm 3843 20 in in IN cord-023095-4dannjjm 3843 21 premature premature JJ cord-023095-4dannjjm 3843 22 discontinuation discontinuation NN cord-023095-4dannjjm 3843 23 of of IN cord-023095-4dannjjm 3843 24 therapy therapy NN cord-023095-4dannjjm 3843 25 in in IN cord-023095-4dannjjm 3843 26 many many JJ cord-023095-4dannjjm 3843 27 of of IN cord-023095-4dannjjm 3843 28 the the DT cord-023095-4dannjjm 3843 29 cases case NNS cord-023095-4dannjjm 3843 30 . . . cord-023095-4dannjjm 3844 1 Monitoring monitoring NN cord-023095-4dannjjm 3844 2 of of IN cord-023095-4dannjjm 3844 3 urine urine NN cord-023095-4dannjjm 3844 4 antigen antigen NN cord-023095-4dannjjm 3844 5 concentrations concentration NNS cord-023095-4dannjjm 3844 6 may may MD cord-023095-4dannjjm 3844 7 be be VB cord-023095-4dannjjm 3844 8 of of IN cord-023095-4dannjjm 3844 9 additional additional JJ cord-023095-4dannjjm 3844 10 clinical clinical JJ cord-023095-4dannjjm 3844 11 use use NN cord-023095-4dannjjm 3844 12 for for IN cord-023095-4dannjjm 3844 13 determining determine VBG cord-023095-4dannjjm 3844 14 when when WRB cord-023095-4dannjjm 3844 15 cessation cessation NN cord-023095-4dannjjm 3844 16 of of IN cord-023095-4dannjjm 3844 17 treatment treatment NN cord-023095-4dannjjm 3844 18 should should MD cord-023095-4dannjjm 3844 19 occur occur VB cord-023095-4dannjjm 3844 20 in in IN cord-023095-4dannjjm 3844 21 cases case NNS cord-023095-4dannjjm 3844 22 of of IN cord-023095-4dannjjm 3844 23 blastomycosis blastomycosis NN cord-023095-4dannjjm 3844 24 . . . cord-023095-4dannjjm 3845 1 Persistent persistent JJ cord-023095-4dannjjm 3845 2 elevation elevation NN cord-023095-4dannjjm 3845 3 of of IN cord-023095-4dannjjm 3845 4 urine urine NN cord-023095-4dannjjm 3845 5 antigen antigen NN cord-023095-4dannjjm 3845 6 concentrations concentration NNS cord-023095-4dannjjm 3845 7 after after IN cord-023095-4dannjjm 3845 8 radiographic radiographic JJ cord-023095-4dannjjm 3845 9 resolution resolution NN cord-023095-4dannjjm 3845 10 of of IN cord-023095-4dannjjm 3845 11 infection infection NN cord-023095-4dannjjm 3845 12 may may MD cord-023095-4dannjjm 3845 13 account account VB cord-023095-4dannjjm 3845 14 for for IN cord-023095-4dannjjm 3845 15 apparent apparent JJ cord-023095-4dannjjm 3845 16 recrudescence recrudescence NN cord-023095-4dannjjm 3845 17 of of IN cord-023095-4dannjjm 3845 18 blastomycosis blastomycosis NN cord-023095-4dannjjm 3845 19 after after IN cord-023095-4dannjjm 3845 20 suspected suspect VBN cord-023095-4dannjjm 3845 21 clinical clinical JJ cord-023095-4dannjjm 3845 22 resolution resolution NN cord-023095-4dannjjm 3845 23 . . . cord-023095-4dannjjm 3846 1 Giardia Giardia NNP cord-023095-4dannjjm 3846 2 spp spp NNS cord-023095-4dannjjm 3846 3 . . . cord-023095-4dannjjm 3847 1 and and CC cord-023095-4dannjjm 3847 2 Cryptosporidium cryptosporidium NN cord-023095-4dannjjm 3847 3 spp spp NNS cord-023095-4dannjjm 3847 4 . . . cord-023095-4dannjjm 3848 1 are be VBP cord-023095-4dannjjm 3848 2 both both DT cord-023095-4dannjjm 3848 3 known know VBN cord-023095-4dannjjm 3848 4 to to TO cord-023095-4dannjjm 3848 5 cause cause VB cord-023095-4dannjjm 3848 6 infections infection NNS cord-023095-4dannjjm 3848 7 in in IN cord-023095-4dannjjm 3848 8 dogs dog NNS cord-023095-4dannjjm 3848 9 and and CC cord-023095-4dannjjm 3848 10 humans human NNS cord-023095-4dannjjm 3848 11 in in IN cord-023095-4dannjjm 3848 12 the the DT cord-023095-4dannjjm 3848 13 United United NNP cord-023095-4dannjjm 3848 14 States States NNP cord-023095-4dannjjm 3848 15 . . . cord-023095-4dannjjm 3849 1 Nevertheless nevertheless RB cord-023095-4dannjjm 3849 2 , , , cord-023095-4dannjjm 3849 3 prevalence prevalence NN cord-023095-4dannjjm 3849 4 rates rate NNS cord-023095-4dannjjm 3849 5 for for IN cord-023095-4dannjjm 3849 6 dual dual JJ cord-023095-4dannjjm 3849 7 infection infection NN cord-023095-4dannjjm 3849 8 in in IN cord-023095-4dannjjm 3849 9 dogs dog NNS cord-023095-4dannjjm 3849 10 had have VBD cord-023095-4dannjjm 3849 11 not not RB cord-023095-4dannjjm 3849 12 been be VBN cord-023095-4dannjjm 3849 13 widely widely RB cord-023095-4dannjjm 3849 14 reported report VBN cord-023095-4dannjjm 3849 15 . . . cord-023095-4dannjjm 3850 1 In in IN cord-023095-4dannjjm 3850 2 this this DT cord-023095-4dannjjm 3850 3 study study NN cord-023095-4dannjjm 3850 4 , , , cord-023095-4dannjjm 3850 5 fecal fecal JJ cord-023095-4dannjjm 3850 6 samples sample NNS cord-023095-4dannjjm 3850 7 from from IN cord-023095-4dannjjm 3850 8 dogs dog NNS cord-023095-4dannjjm 3850 9 housed house VBN cord-023095-4dannjjm 3850 10 in in IN cord-023095-4dannjjm 3850 11 a a DT cord-023095-4dannjjm 3850 12 northern northern JJ cord-023095-4dannjjm 3850 13 Colorado Colorado NNP cord-023095-4dannjjm 3850 14 animal animal NN cord-023095-4dannjjm 3850 15 shelter shelter NN cord-023095-4dannjjm 3850 16 ( ( -LRB- cord-023095-4dannjjm 3850 17 n n NN cord-023095-4dannjjm 3850 18 5 5 CD cord-023095-4dannjjm 3850 19 121 121 CD cord-023095-4dannjjm 3850 20 ) ) -RRB- cord-023095-4dannjjm 3850 21 , , , cord-023095-4dannjjm 3850 22 dogs dog NNS cord-023095-4dannjjm 3850 23 owned own VBN cord-023095-4dannjjm 3850 24 by by IN cord-023095-4dannjjm 3850 25 veterinary veterinary JJ cord-023095-4dannjjm 3850 26 students student NNS cord-023095-4dannjjm 3850 27 in in IN cord-023095-4dannjjm 3850 28 northern northern JJ cord-023095-4dannjjm 3850 29 Colorado Colorado NNP cord-023095-4dannjjm 3850 30 ( ( -LRB- cord-023095-4dannjjm 3850 31 n n NN cord-023095-4dannjjm 3850 32 5 5 CD cord-023095-4dannjjm 3850 33 132 132 CD cord-023095-4dannjjm 3850 34 ) ) -RRB- cord-023095-4dannjjm 3850 35 , , , cord-023095-4dannjjm 3850 36 and and CC cord-023095-4dannjjm 3850 37 dogs dog NNS cord-023095-4dannjjm 3850 38 from from IN cord-023095-4dannjjm 3850 39 the the DT cord-023095-4dannjjm 3850 40 Pine Pine NNP cord-023095-4dannjjm 3850 41 Ridge Ridge NNP cord-023095-4dannjjm 3850 42 reservation reservation NN cord-023095-4dannjjm 3850 43 in in IN cord-023095-4dannjjm 3850 44 South South NNP cord-023095-4dannjjm 3850 45 Dakota Dakota NNP cord-023095-4dannjjm 3850 46 ( ( -LRB- cord-023095-4dannjjm 3850 47 n n NN cord-023095-4dannjjm 3850 48 5 5 CD cord-023095-4dannjjm 3850 49 84 84 CD cord-023095-4dannjjm 3850 50 ) ) -RRB- cord-023095-4dannjjm 3850 51 were be VBD cord-023095-4dannjjm 3850 52 collected collect VBN cord-023095-4dannjjm 3850 53 . . . cord-023095-4dannjjm 3851 1 Each each DT cord-023095-4dannjjm 3851 2 sample sample NN cord-023095-4dannjjm 3851 3 was be VBD cord-023095-4dannjjm 3851 4 assayed assay VBN cord-023095-4dannjjm 3851 5 with with IN cord-023095-4dannjjm 3851 6 a a DT cord-023095-4dannjjm 3851 7 commercially commercially RB cord-023095-4dannjjm 3851 8 available available JJ cord-023095-4dannjjm 3851 9 fluorescent fluorescent JJ cord-023095-4dannjjm 3851 10 antibody antibody NN cord-023095-4dannjjm 3851 11 assay assay NN cord-023095-4dannjjm 3851 12 that that WDT cord-023095-4dannjjm 3851 13 detects detect VBZ cord-023095-4dannjjm 3851 14 Giardia Giardia NNP cord-023095-4dannjjm 3851 15 spp spp NNS cord-023095-4dannjjm 3851 16 . . . cord-023095-4dannjjm 3852 1 cysts cyst NNS cord-023095-4dannjjm 3852 2 and and CC cord-023095-4dannjjm 3852 3 Cryptosporidium cryptosporidium NN cord-023095-4dannjjm 3852 4 spp spp NNS cord-023095-4dannjjm 3852 5 . . . cord-023095-4dannjjm 3853 1 oocysts oocyst NNS cord-023095-4dannjjm 3853 2 . . . cord-023095-4dannjjm 3854 1 Those those DT cord-023095-4dannjjm 3854 2 samples sample NNS cord-023095-4dannjjm 3854 3 that that WDT cord-023095-4dannjjm 3854 4 were be VBD cord-023095-4dannjjm 3854 5 positive positive JJ cord-023095-4dannjjm 3854 6 for for IN cord-023095-4dannjjm 3854 7 Giardia Giardia NNP cord-023095-4dannjjm 3854 8 spp spp NNS cord-023095-4dannjjm 3854 9 . . . cord-023095-4dannjjm 3855 1 or or CC cord-023095-4dannjjm 3855 2 Cryptosporidium cryptosporidium NN cord-023095-4dannjjm 3855 3 spp spp NNS cord-023095-4dannjjm 3855 4 . . . cord-023095-4dannjjm 3856 1 with with IN cord-023095-4dannjjm 3856 2 adequate adequate JJ cord-023095-4dannjjm 3856 3 DNA dna NN cord-023095-4dannjjm 3856 4 available available JJ cord-023095-4dannjjm 3856 5 for for IN cord-023095-4dannjjm 3856 6 sequencing sequencing NN cord-023095-4dannjjm 3856 7 were be VBD cord-023095-4dannjjm 3856 8 genotyped genotype VBN cord-023095-4dannjjm 3856 9 by by IN cord-023095-4dannjjm 3856 10 the the DT cord-023095-4dannjjm 3856 11 glutamate glutamate NN cord-023095-4dannjjm 3856 12 dehydrogenase dehydrogenase NN cord-023095-4dannjjm 3856 13 [ [ -LRB- cord-023095-4dannjjm 3856 14 gdh gdh NN cord-023095-4dannjjm 3856 15 ] ] -RRB- cord-023095-4dannjjm 3856 16 and and CC cord-023095-4dannjjm 3856 17 by by IN cord-023095-4dannjjm 3856 18 the the DT cord-023095-4dannjjm 3856 19 heat heat NN cord-023095-4dannjjm 3856 20 shock shock NN cord-023095-4dannjjm 3856 21 protein-70 protein-70 XX cord-023095-4dannjjm 3856 22 [ [ -LRB- cord-023095-4dannjjm 3856 23 HSP-70 HSP-70 NNP cord-023095-4dannjjm 3856 24 ] ] -RRB- cord-023095-4dannjjm 3856 25 genes gene NNS cord-023095-4dannjjm 3856 26 , , , cord-023095-4dannjjm 3856 27 respectively respectively RB cord-023095-4dannjjm 3856 28 . . . cord-023095-4dannjjm 3857 1 Overall overall RB cord-023095-4dannjjm 3857 2 , , , cord-023095-4dannjjm 3857 3 45 45 CD cord-023095-4dannjjm 3857 4 ( ( -LRB- cord-023095-4dannjjm 3857 5 13.3 13.3 CD cord-023095-4dannjjm 3857 6 % % NN cord-023095-4dannjjm 3857 7 ) ) -RRB- cord-023095-4dannjjm 3857 8 of of IN cord-023095-4dannjjm 3857 9 the the DT cord-023095-4dannjjm 3857 10 dogs dog NNS cord-023095-4dannjjm 3857 11 had have VBD cord-023095-4dannjjm 3857 12 current current JJ cord-023095-4dannjjm 3857 13 evidence evidence NN cord-023095-4dannjjm 3857 14 of of IN cord-023095-4dannjjm 3857 15 a a DT cord-023095-4dannjjm 3857 16 protozoal protozoal JJ cord-023095-4dannjjm 3857 17 infection infection NN cord-023095-4dannjjm 3857 18 ( ( -LRB- cord-023095-4dannjjm 3857 19 Table table NN cord-023095-4dannjjm 3857 20 1 1 CD cord-023095-4dannjjm 3857 21 ) ) -RRB- cord-023095-4dannjjm 3857 22 . . . cord-023095-4dannjjm 3858 1 The the DT cord-023095-4dannjjm 3858 2 dogs dog NNS cord-023095-4dannjjm 3858 3 from from IN cord-023095-4dannjjm 3858 4 Pine Pine NNP cord-023095-4dannjjm 3858 5 Ridge Ridge NNP cord-023095-4dannjjm 3858 6 reservation reservation NN cord-023095-4dannjjm 3858 7 had have VBD cord-023095-4dannjjm 3858 8 the the DT cord-023095-4dannjjm 3858 9 highest high JJS cord-023095-4dannjjm 3858 10 prevalence prevalence NN cord-023095-4dannjjm 3858 11 rates rate NNS cord-023095-4dannjjm 3858 12 for for IN cord-023095-4dannjjm 3858 13 Giardia Giardia NNP cord-023095-4dannjjm 3858 14 infection infection NN cord-023095-4dannjjm 3858 15 and and CC cord-023095-4dannjjm 3858 16 also also RB cord-023095-4dannjjm 3858 17 for for IN cord-023095-4dannjjm 3858 18 dual dual JJ cord-023095-4dannjjm 3858 19 infections infection NNS cord-023095-4dannjjm 3858 20 . . . cord-023095-4dannjjm 3859 1 From from IN cord-023095-4dannjjm 3859 2 the the DT cord-023095-4dannjjm 3859 3 student student NN cord-023095-4dannjjm 3859 4 dogs dog NNS cord-023095-4dannjjm 3859 5 , , , cord-023095-4dannjjm 3859 6 sequencing sequencing NN cord-023095-4dannjjm 3859 7 was be VBD cord-023095-4dannjjm 3859 8 successful successful JJ cord-023095-4dannjjm 3859 9 for for IN cord-023095-4dannjjm 3859 10 the the DT cord-023095-4dannjjm 3859 11 three three CD cord-023095-4dannjjm 3859 12 Giardia Giardia NNP cord-023095-4dannjjm 3859 13 isolates isolate NNS cord-023095-4dannjjm 3859 14 ( ( -LRB- cord-023095-4dannjjm 3859 15 assemblage assemblage NN cord-023095-4dannjjm 3859 16 D d NN cord-023095-4dannjjm 3859 17 from from IN cord-023095-4dannjjm 3859 18 2 2 CD cord-023095-4dannjjm 3859 19 dogs dog NNS cord-023095-4dannjjm 3859 20 ; ; : cord-023095-4dannjjm 3859 21 assemblage assemblage NN cord-023095-4dannjjm 3859 22 C c NN cord-023095-4dannjjm 3859 23 from from IN cord-023095-4dannjjm 3859 24 one one CD cord-023095-4dannjjm 3859 25 dog dog NN cord-023095-4dannjjm 3859 26 ) ) -RRB- cord-023095-4dannjjm 3859 27 and and CC cord-023095-4dannjjm 3859 28 one one CD cord-023095-4dannjjm 3859 29 Cryptosporidium cryptosporidium NN cord-023095-4dannjjm 3859 30 isolate isolate NN cord-023095-4dannjjm 3859 31 ( ( -LRB- cord-023095-4dannjjm 3859 32 C. C. NNP cord-023095-4dannjjm 3859 33 canis canis NNP cord-023095-4dannjjm 3859 34 ) ) -RRB- cord-023095-4dannjjm 3859 35 . . . cord-023095-4dannjjm 3860 1 From from IN cord-023095-4dannjjm 3860 2 the the DT cord-023095-4dannjjm 3860 3 reservation reservation NN cord-023095-4dannjjm 3860 4 dogs dog NNS cord-023095-4dannjjm 3860 5 , , , cord-023095-4dannjjm 3860 6 sequencing sequencing NN cord-023095-4dannjjm 3860 7 was be VBD cord-023095-4dannjjm 3860 8 successful successful JJ cord-023095-4dannjjm 3860 9 for for IN cord-023095-4dannjjm 3860 10 nine nine CD cord-023095-4dannjjm 3860 11 Giardia Giardia NNP cord-023095-4dannjjm 3860 12 isolates isolate NNS cord-023095-4dannjjm 3860 13 ( ( -LRB- cord-023095-4dannjjm 3860 14 assemblage assemblage NN cord-023095-4dannjjm 3860 15 D d NN cord-023095-4dannjjm 3860 16 from from IN cord-023095-4dannjjm 3860 17 4 4 CD cord-023095-4dannjjm 3860 18 dogs dog NNS cord-023095-4dannjjm 3860 19 ; ; : cord-023095-4dannjjm 3860 20 assemblage assemblage NN cord-023095-4dannjjm 3860 21 C c NN cord-023095-4dannjjm 3860 22 from from IN cord-023095-4dannjjm 3860 23 5 5 CD cord-023095-4dannjjm 3860 24 dogs dog NNS cord-023095-4dannjjm 3860 25 ) ) -RRB- cord-023095-4dannjjm 3860 26 and and CC cord-023095-4dannjjm 3860 27 one one CD cord-023095-4dannjjm 3860 28 Cryptosporidium cryptosporidium NN cord-023095-4dannjjm 3860 29 isolate isolate NN cord-023095-4dannjjm 3860 30 ( ( -LRB- cord-023095-4dannjjm 3860 31 C. C. NNP cord-023095-4dannjjm 3860 32 canis canis NNP cord-023095-4dannjjm 3860 33 ) ) -RRB- cord-023095-4dannjjm 3860 34 . . . cord-023095-4dannjjm 3861 1 Cryptosporidium Cryptosporidium NNP cord-023095-4dannjjm 3861 2 and and CC cord-023095-4dannjjm 3861 3 Giardia Giardia NNP cord-023095-4dannjjm 3861 4 co co NNS cord-023095-4dannjjm 3861 5 - - NNS cord-023095-4dannjjm 3861 6 infections infection NNS cord-023095-4dannjjm 3861 7 are be VBP cord-023095-4dannjjm 3861 8 commonly commonly RB cord-023095-4dannjjm 3861 9 detected detect VBN cord-023095-4dannjjm 3861 10 in in IN cord-023095-4dannjjm 3861 11 dogs dog NNS cord-023095-4dannjjm 3861 12 ; ; : cord-023095-4dannjjm 3861 13 in in IN cord-023095-4dannjjm 3861 14 this this DT cord-023095-4dannjjm 3861 15 study study NN cord-023095-4dannjjm 3861 16 dual dual JJ cord-023095-4dannjjm 3861 17 infections infection NNS cord-023095-4dannjjm 3861 18 were be VBD cord-023095-4dannjjm 3861 19 more more RBR cord-023095-4dannjjm 3861 20 common common JJ cord-023095-4dannjjm 3861 21 than than IN cord-023095-4dannjjm 3861 22 Cryptosporidium cryptosporidium NN cord-023095-4dannjjm 3861 23 infections infection NNS cord-023095-4dannjjm 3861 24 alone alone RB cord-023095-4dannjjm 3861 25 . . . cord-023095-4dannjjm 3862 1 Further further JJ cord-023095-4dannjjm 3862 2 studies study NNS cord-023095-4dannjjm 3862 3 will will MD cord-023095-4dannjjm 3862 4 be be VB cord-023095-4dannjjm 3862 5 required require VBN cord-023095-4dannjjm 3862 6 to to TO cord-023095-4dannjjm 3862 7 determine determine VB cord-023095-4dannjjm 3862 8 the the DT cord-023095-4dannjjm 3862 9 clinical clinical JJ cord-023095-4dannjjm 3862 10 importance importance NN cord-023095-4dannjjm 3862 11 of of IN cord-023095-4dannjjm 3862 12 this this DT cord-023095-4dannjjm 3862 13 finding finding NN cord-023095-4dannjjm 3862 14 . . . cord-023095-4dannjjm 3863 1 Although although IN cord-023095-4dannjjm 3863 2 the the DT cord-023095-4dannjjm 3863 3 Giardia Giardia NNP cord-023095-4dannjjm 3863 4 and and CC cord-023095-4dannjjm 3863 5 Cryptosporidium Cryptosporidium NNP cord-023095-4dannjjm 3863 6 isolates isolate VBZ cord-023095-4dannjjm 3863 7 that that WDT cord-023095-4dannjjm 3863 8 were be VBD cord-023095-4dannjjm 3863 9 sequenced sequence VBN cord-023095-4dannjjm 3863 10 were be VBD cord-023095-4dannjjm 3863 11 the the DT cord-023095-4dannjjm 3863 12 dog dog NN cord-023095-4dannjjm 3863 13 specific specific JJ cord-023095-4dannjjm 3863 14 assemblages assemblage NNS cord-023095-4dannjjm 3863 15 / / SYM cord-023095-4dannjjm 3863 16 genotypes genotype NNS cord-023095-4dannjjm 3863 17 , , , cord-023095-4dannjjm 3863 18 more more JJR cord-023095-4dannjjm 3863 19 samples sample NNS cord-023095-4dannjjm 3863 20 should should MD cord-023095-4dannjjm 3863 21 be be VB cord-023095-4dannjjm 3863 22 analyzed analyze VBN cord-023095-4dannjjm 3863 23 in in IN cord-023095-4dannjjm 3863 24 order order NN cord-023095-4dannjjm 3863 25 to to TO cord-023095-4dannjjm 3863 26 assess assess VB cord-023095-4dannjjm 3863 27 the the DT cord-023095-4dannjjm 3863 28 potential potential NN cord-023095-4dannjjm 3863 29 for for IN cord-023095-4dannjjm 3863 30 zoonotic zoonotic JJ cord-023095-4dannjjm 3863 31 transmission transmission NN cord-023095-4dannjjm 3863 32 of of IN cord-023095-4dannjjm 3863 33 either either DT cord-023095-4dannjjm 3863 34 parasite parasite NN cord-023095-4dannjjm 3863 35 . . . cord-023095-4dannjjm 3864 1 The the DT cord-023095-4dannjjm 3864 2 current current JJ cord-023095-4dannjjm 3864 3 study study NN cord-023095-4dannjjm 3864 4 was be VBD cord-023095-4dannjjm 3864 5 conducted conduct VBN cord-023095-4dannjjm 3864 6 to to TO cord-023095-4dannjjm 3864 7 determine determine VB cord-023095-4dannjjm 3864 8 the the DT cord-023095-4dannjjm 3864 9 prevalence prevalence NN cord-023095-4dannjjm 3864 10 of of IN cord-023095-4dannjjm 3864 11 intestinal intestinal JJ cord-023095-4dannjjm 3864 12 parasites parasite NNS cord-023095-4dannjjm 3864 13 in in IN cord-023095-4dannjjm 3864 14 dogs dog NNS cord-023095-4dannjjm 3864 15 visiting visit VBG cord-023095-4dannjjm 3864 16 the the DT cord-023095-4dannjjm 3864 17 Veterinary Veterinary NNP cord-023095-4dannjjm 3864 18 Teaching Teaching NNP cord-023095-4dannjjm 3864 19 Hospital Hospital NNP cord-023095-4dannjjm 3864 20 , , , cord-023095-4dannjjm 3864 21 Chiang Chiang NNP cord-023095-4dannjjm 3864 22 Mai Mai NNP cord-023095-4dannjjm 3864 23 University University NNP cord-023095-4dannjjm 3864 24 , , , cord-023095-4dannjjm 3864 25 Northern Northern NNP cord-023095-4dannjjm 3864 26 Thailand Thailand NNP cord-023095-4dannjjm 3864 27 . . . cord-023095-4dannjjm 3865 1 Fecal fecal JJ cord-023095-4dannjjm 3865 2 samples sample NNS cord-023095-4dannjjm 3865 3 ( ( -LRB- cord-023095-4dannjjm 3865 4 n n NN cord-023095-4dannjjm 3865 5 5 5 CD cord-023095-4dannjjm 3865 6 301 301 CD cord-023095-4dannjjm 3865 7 ) ) -RRB- cord-023095-4dannjjm 3865 8 were be VBD cord-023095-4dannjjm 3865 9 collected collect VBN cord-023095-4dannjjm 3865 10 and and CC cord-023095-4dannjjm 3865 11 submitted submit VBN cord-023095-4dannjjm 3865 12 by by IN cord-023095-4dannjjm 3865 13 owners owner NNS cord-023095-4dannjjm 3865 14 between between IN cord-023095-4dannjjm 3865 15 August August NNP cord-023095-4dannjjm 3865 16 2009 2009 CD cord-023095-4dannjjm 3865 17 to to IN cord-023095-4dannjjm 3865 18 February February NNP cord-023095-4dannjjm 3865 19 2010 2010 CD cord-023095-4dannjjm 3865 20 . . . cord-023095-4dannjjm 3866 1 Demographic demographic JJ cord-023095-4dannjjm 3866 2 and and CC cord-023095-4dannjjm 3866 3 geographic geographic JJ cord-023095-4dannjjm 3866 4 data datum NNS cord-023095-4dannjjm 3866 5 were be VBD cord-023095-4dannjjm 3866 6 recorded record VBN cord-023095-4dannjjm 3866 7 . . . cord-023095-4dannjjm 3867 1 Intestinal intestinal JJ cord-023095-4dannjjm 3867 2 parasitic parasitic JJ cord-023095-4dannjjm 3867 3 infection infection NN cord-023095-4dannjjm 3867 4 was be VBD cord-023095-4dannjjm 3867 5 diagnosed diagnose VBN cord-023095-4dannjjm 3867 6 by by IN cord-023095-4dannjjm 3867 7 both both DT cord-023095-4dannjjm 3867 8 microscopic microscopic JJ cord-023095-4dannjjm 3867 9 examination examination NN cord-023095-4dannjjm 3867 10 after after IN cord-023095-4dannjjm 3867 11 zinc zinc NN cord-023095-4dannjjm 3867 12 sulfate sulfate NN cord-023095-4dannjjm 3867 13 centrifugation centrifugation NN cord-023095-4dannjjm 3867 14 flotation flotation NN cord-023095-4dannjjm 3867 15 and and CC cord-023095-4dannjjm 3867 16 commercially commercially RB cord-023095-4dannjjm 3867 17 available available JJ cord-023095-4dannjjm 3867 18 IFA IFA NNP cord-023095-4dannjjm 3867 19 for for IN cord-023095-4dannjjm 3867 20 Giardia Giardia NNP cord-023095-4dannjjm 3867 21 spp spp NNS cord-023095-4dannjjm 3867 22 . . . cord-023095-4dannjjm 3868 1 and and CC cord-023095-4dannjjm 3868 2 Cryptosporidium cryptosporidium NN cord-023095-4dannjjm 3868 3 spp spp NNS cord-023095-4dannjjm 3868 4 . . . cord-023095-4dannjjm 3869 1 Polymerase polymerase NN cord-023095-4dannjjm 3869 2 chain chain NN cord-023095-4dannjjm 3869 3 reaction reaction NN cord-023095-4dannjjm 3869 4 and and CC cord-023095-4dannjjm 3869 5 DNA dna NN cord-023095-4dannjjm 3869 6 sequencing sequencing NN cord-023095-4dannjjm 3869 7 were be VBD cord-023095-4dannjjm 3869 8 performed perform VBN cord-023095-4dannjjm 3869 9 on on IN cord-023095-4dannjjm 3869 10 all all DT cord-023095-4dannjjm 3869 11 Giardia Giardia NNP cord-023095-4dannjjm 3869 12 and and CC cord-023095-4dannjjm 3869 13 Cryptosporidium cryptosporidium NN cord-023095-4dannjjm 3869 14 positive positive JJ cord-023095-4dannjjm 3869 15 samples sample NNS cord-023095-4dannjjm 3869 16 to to TO cord-023095-4dannjjm 3869 17 provide provide VB cord-023095-4dannjjm 3869 18 genotyic genotyic NNS cord-023095-4dannjjm 3869 19 information information NN cord-023095-4dannjjm 3869 20 . . . cord-023095-4dannjjm 3870 1 Overall overall JJ cord-023095-4dannjjm 3870 2 prevalence prevalence NN cord-023095-4dannjjm 3870 3 of of IN cord-023095-4dannjjm 3870 4 intestinal intestinal JJ cord-023095-4dannjjm 3870 5 parasitic parasitic JJ cord-023095-4dannjjm 3870 6 infection infection NN cord-023095-4dannjjm 3870 7 in in IN cord-023095-4dannjjm 3870 8 dogs dog NNS cord-023095-4dannjjm 3870 9 in in IN cord-023095-4dannjjm 3870 10 Chiang Chiang NNP cord-023095-4dannjjm 3870 11 Mai Mai NNP cord-023095-4dannjjm 3870 12 was be VBD cord-023095-4dannjjm 3870 13 38.9 38.9 CD cord-023095-4dannjjm 3870 14 % % NN cord-023095-4dannjjm 3870 15 . . . cord-023095-4dannjjm 3871 1 The the DT cord-023095-4dannjjm 3871 2 most most RBS cord-023095-4dannjjm 3871 3 prevalent prevalent JJ cord-023095-4dannjjm 3871 4 parasite parasite NN cord-023095-4dannjjm 3871 5 was be VBD cord-023095-4dannjjm 3871 6 Giardia Giardia NNP cord-023095-4dannjjm 3871 7 spp spp NNS cord-023095-4dannjjm 3871 8 . . . cord-023095-4dannjjm 3872 1 ( ( -LRB- cord-023095-4dannjjm 3872 2 24.9 24.9 CD cord-023095-4dannjjm 3872 3 % % NN cord-023095-4dannjjm 3872 4 ) ) -RRB- cord-023095-4dannjjm 3872 5 followed follow VBN cord-023095-4dannjjm 3872 6 by by IN cord-023095-4dannjjm 3872 7 Ancylostoma Ancylostoma NNP cord-023095-4dannjjm 3872 8 spp spp NNS cord-023095-4dannjjm 3872 9 . . . cord-023095-4dannjjm 3873 1 ( ( -LRB- cord-023095-4dannjjm 3873 2 12.0 12.0 CD cord-023095-4dannjjm 3873 3 % % NN cord-023095-4dannjjm 3873 4 ) ) -RRB- cord-023095-4dannjjm 3873 5 , , , cord-023095-4dannjjm 3873 6 Cryptosporidium cryptosporidium NN cord-023095-4dannjjm 3873 7 spp spp NNS cord-023095-4dannjjm 3873 8 . . . cord-023095-4dannjjm 3874 1 ( ( -LRB- cord-023095-4dannjjm 3874 2 7.6 7.6 CD cord-023095-4dannjjm 3874 3 % % NN cord-023095-4dannjjm 3874 4 ) ) -RRB- cord-023095-4dannjjm 3874 5 , , , cord-023095-4dannjjm 3874 6 Cystoisospora Cystoisospora NNP cord-023095-4dannjjm 3874 7 spp spp NNS cord-023095-4dannjjm 3874 8 . . . cord-023095-4dannjjm 3875 1 ( ( -LRB- cord-023095-4dannjjm 3875 2 6.0 6.0 CD cord-023095-4dannjjm 3875 3 % % NN cord-023095-4dannjjm 3875 4 ) ) -RRB- cord-023095-4dannjjm 3875 5 , , , cord-023095-4dannjjm 3875 6 Toxocara Toxocara NNP cord-023095-4dannjjm 3875 7 canis canis NN cord-023095-4dannjjm 3875 8 ( ( -LRB- cord-023095-4dannjjm 3875 9 2.7 2.7 CD cord-023095-4dannjjm 3875 10 % % NN cord-023095-4dannjjm 3875 11 ) ) -RRB- cord-023095-4dannjjm 3875 12 , , , cord-023095-4dannjjm 3875 13 Trichuris Trichuris NNP cord-023095-4dannjjm 3875 14 vulpis vulpis NNP cord-023095-4dannjjm 3875 15 ( ( -LRB- cord-023095-4dannjjm 3875 16 2.0 2.0 CD cord-023095-4dannjjm 3875 17 % % NN cord-023095-4dannjjm 3875 18 ) ) -RRB- cord-023095-4dannjjm 3875 19 , , , cord-023095-4dannjjm 3875 20 coccidian coccidian NN cord-023095-4dannjjm 3875 21 - - HYPH cord-023095-4dannjjm 3875 22 like like JJ cord-023095-4dannjjm 3875 23 ( ( -LRB- cord-023095-4dannjjm 3875 24 1.7 1.7 CD cord-023095-4dannjjm 3875 25 % % NN cord-023095-4dannjjm 3875 26 ) ) -RRB- cord-023095-4dannjjm 3875 27 , , , cord-023095-4dannjjm 3875 28 Toxascaris Toxascaris NNP cord-023095-4dannjjm 3875 29 leonina leonina NNP cord-023095-4dannjjm 3875 30 ( ( -LRB- cord-023095-4dannjjm 3875 31 0.7 0.7 CD cord-023095-4dannjjm 3875 32 % % NN cord-023095-4dannjjm 3875 33 ) ) -RRB- cord-023095-4dannjjm 3875 34 , , , cord-023095-4dannjjm 3875 35 and and CC cord-023095-4dannjjm 3875 36 Strongyloides Strongyloides NNP cord-023095-4dannjjm 3875 37 spp spp NNP cord-023095-4dannjjm 3875 38 . . . cord-023095-4dannjjm 3876 1 ( ( -LRB- cord-023095-4dannjjm 3876 2 0.7 0.7 CD cord-023095-4dannjjm 3876 3 % % NN cord-023095-4dannjjm 3876 4 ) ) -RRB- cord-023095-4dannjjm 3876 5 . . . cord-023095-4dannjjm 3877 1 The the DT cord-023095-4dannjjm 3877 2 prevalence prevalence NN cord-023095-4dannjjm 3877 3 of of IN cord-023095-4dannjjm 3877 4 having have VBG cord-023095-4dannjjm 3877 5 at at RB cord-023095-4dannjjm 3877 6 least least RBS cord-023095-4dannjjm 3877 7 one one CD cord-023095-4dannjjm 3877 8 parasite parasite NN cord-023095-4dannjjm 3877 9 in in IN cord-023095-4dannjjm 3877 10 dogs dog NNS cord-023095-4dannjjm 3877 11 o o NN cord-023095-4dannjjm 3877 12 1 1 CD cord-023095-4dannjjm 3877 13 year year NN cord-023095-4dannjjm 3877 14 , , , cord-023095-4dannjjm 3877 15 1 1 CD cord-023095-4dannjjm 3877 16 - - SYM cord-023095-4dannjjm 3877 17 7 7 CD cord-023095-4dannjjm 3877 18 years year NNS cord-023095-4dannjjm 3877 19 , , , cord-023095-4dannjjm 3877 20 and and CC cord-023095-4dannjjm 3877 21 4 4 CD cord-023095-4dannjjm 3877 22 7 7 CD cord-023095-4dannjjm 3877 23 years year NNS cord-023095-4dannjjm 3877 24 were be VBD cord-023095-4dannjjm 3877 25 49.3 49.3 CD cord-023095-4dannjjm 3877 26 % % NN cord-023095-4dannjjm 3877 27 , , , cord-023095-4dannjjm 3877 28 39.8 39.8 CD cord-023095-4dannjjm 3877 29 % % NN cord-023095-4dannjjm 3877 30 , , , cord-023095-4dannjjm 3877 31 and and CC cord-023095-4dannjjm 3877 32 27.4 27.4 CD cord-023095-4dannjjm 3877 33 % % NN cord-023095-4dannjjm 3877 34 , , , cord-023095-4dannjjm 3877 35 respectively respectively RB cord-023095-4dannjjm 3877 36 . . . cord-023095-4dannjjm 3878 1 Of of IN cord-023095-4dannjjm 3878 2 these these DT cord-023095-4dannjjm 3878 3 infected infect VBN cord-023095-4dannjjm 3878 4 dogs dog NNS cord-023095-4dannjjm 3878 5 , , , cord-023095-4dannjjm 3878 6 59.0 59.0 CD cord-023095-4dannjjm 3878 7 % % NN cord-023095-4dannjjm 3878 8 , , , cord-023095-4dannjjm 3878 9 34.2 34.2 CD cord-023095-4dannjjm 3878 10 % % NN cord-023095-4dannjjm 3878 11 , , , cord-023095-4dannjjm 3878 12 5.1 5.1 CD cord-023095-4dannjjm 3878 13 % % NN cord-023095-4dannjjm 3878 14 , , , cord-023095-4dannjjm 3878 15 and and CC cord-023095-4dannjjm 3878 16 1.7 1.7 CD cord-023095-4dannjjm 3878 17 % % NN cord-023095-4dannjjm 3878 18 were be VBD cord-023095-4dannjjm 3878 19 infected infect VBN cord-023095-4dannjjm 3878 20 with with IN cord-023095-4dannjjm 3878 21 one one CD cord-023095-4dannjjm 3878 22 , , , cord-023095-4dannjjm 3878 23 two two CD cord-023095-4dannjjm 3878 24 , , , cord-023095-4dannjjm 3878 25 three three CD cord-023095-4dannjjm 3878 26 , , , cord-023095-4dannjjm 3878 27 and and CC cord-023095-4dannjjm 3878 28 four four CD cord-023095-4dannjjm 3878 29 organisms organism NNS cord-023095-4dannjjm 3878 30 , , , cord-023095-4dannjjm 3878 31 respectively respectively RB cord-023095-4dannjjm 3878 32 . . . cord-023095-4dannjjm 3879 1 Available available JJ cord-023095-4dannjjm 3879 2 DNA dna NN cord-023095-4dannjjm 3879 3 sequences sequence NNS cord-023095-4dannjjm 3879 4 from from IN cord-023095-4dannjjm 3879 5 Giardia Giardia NNP cord-023095-4dannjjm 3879 6 spp spp NNS cord-023095-4dannjjm 3879 7 . . . cord-023095-4dannjjm 3880 1 positive positive JJ cord-023095-4dannjjm 3880 2 samples sample NNS cord-023095-4dannjjm 3880 3 were be VBD cord-023095-4dannjjm 3880 4 shown show VBN cord-023095-4dannjjm 3880 5 to to TO cord-023095-4dannjjm 3880 6 be be VB cord-023095-4dannjjm 3880 7 dog dog NN cord-023095-4dannjjm 3880 8 specific specific JJ cord-023095-4dannjjm 3880 9 . . . cord-023095-4dannjjm 3881 1 Only only RB cord-023095-4dannjjm 3881 2 one one CD cord-023095-4dannjjm 3881 3 adequate adequate JJ cord-023095-4dannjjm 3881 4 DNA dna NN cord-023095-4dannjjm 3881 5 sequence sequence NN cord-023095-4dannjjm 3881 6 was be VBD cord-023095-4dannjjm 3881 7 available available JJ cord-023095-4dannjjm 3881 8 for for IN cord-023095-4dannjjm 3881 9 Cryptosporidium cryptosporidium NN cord-023095-4dannjjm 3881 10 spp spp NNS cord-023095-4dannjjm 3881 11 . . . cord-023095-4dannjjm 3882 1 , , , cord-023095-4dannjjm 3882 2 which which WDT cord-023095-4dannjjm 3882 3 was be VBD cord-023095-4dannjjm 3882 4 shown show VBN cord-023095-4dannjjm 3882 5 to to TO cord-023095-4dannjjm 3882 6 be be VB cord-023095-4dannjjm 3882 7 C. C. NNP cord-023095-4dannjjm 3882 8 canis canis NNP cord-023095-4dannjjm 3882 9 . . . cord-023095-4dannjjm 3883 1 The the DT cord-023095-4dannjjm 3883 2 findings finding NNS cord-023095-4dannjjm 3883 3 suggested suggest VBD cord-023095-4dannjjm 3883 4 that that IN cord-023095-4dannjjm 3883 5 intestinal intestinal JJ cord-023095-4dannjjm 3883 6 parasitic parasitic JJ cord-023095-4dannjjm 3883 7 infection infection NN cord-023095-4dannjjm 3883 8 was be VBD cord-023095-4dannjjm 3883 9 common common JJ cord-023095-4dannjjm 3883 10 in in IN cord-023095-4dannjjm 3883 11 dogs dog NNS cord-023095-4dannjjm 3883 12 in in IN cord-023095-4dannjjm 3883 13 Chiang Chiang NNP cord-023095-4dannjjm 3883 14 Mai Mai NNP cord-023095-4dannjjm 3883 15 , , , cord-023095-4dannjjm 3883 16 Thailand Thailand NNP cord-023095-4dannjjm 3883 17 . . . cord-023095-4dannjjm 3884 1 Dogs dog NNS cord-023095-4dannjjm 3884 2 could could MD cord-023095-4dannjjm 3884 3 be be VB cord-023095-4dannjjm 3884 4 potential potential JJ cord-023095-4dannjjm 3884 5 source source NN cord-023095-4dannjjm 3884 6 for for IN cord-023095-4dannjjm 3884 7 zoonotic zoonotic JJ cord-023095-4dannjjm 3884 8 intestinal intestinal JJ cord-023095-4dannjjm 3884 9 parasitic parasitic JJ cord-023095-4dannjjm 3884 10 infection infection NN cord-023095-4dannjjm 3884 11 since since IN cord-023095-4dannjjm 3884 12 dogs dog NNS cord-023095-4dannjjm 3884 13 in in IN cord-023095-4dannjjm 3884 14 this this DT cord-023095-4dannjjm 3884 15 area area NN cord-023095-4dannjjm 3884 16 are be VBP cord-023095-4dannjjm 3884 17 allowed allow VBN cord-023095-4dannjjm 3884 18 for for IN cord-023095-4dannjjm 3884 19 free free JJ cord-023095-4dannjjm 3884 20 roaming roaming NN cord-023095-4dannjjm 3884 21 . . . cord-023095-4dannjjm 3885 1 Regular regular JJ cord-023095-4dannjjm 3885 2 deworming deworme VBG cord-023095-4dannjjm 3885 3 program program NN cord-023095-4dannjjm 3885 4 is be VBZ cord-023095-4dannjjm 3885 5 indicated indicate VBN cord-023095-4dannjjm 3885 6 to to TO cord-023095-4dannjjm 3885 7 prevent prevent VB cord-023095-4dannjjm 3885 8 not not RB cord-023095-4dannjjm 3885 9 only only JJ cord-023095-4dannjjm 3885 10 transmission transmission NN cord-023095-4dannjjm 3885 11 among among IN cord-023095-4dannjjm 3885 12 dogs dog NNS cord-023095-4dannjjm 3885 13 but but CC cord-023095-4dannjjm 3885 14 also also RB cord-023095-4dannjjm 3885 15 to to IN cord-023095-4dannjjm 3885 16 human human NN cord-023095-4dannjjm 3885 17 . . . cord-023095-4dannjjm 3886 1 A a DT cord-023095-4dannjjm 3886 2 retrospective retrospective JJ cord-023095-4dannjjm 3886 3 study study NN cord-023095-4dannjjm 3886 4 was be VBD cord-023095-4dannjjm 3886 5 conducted conduct VBN cord-023095-4dannjjm 3886 6 on on IN cord-023095-4dannjjm 3886 7 135 135 CD cord-023095-4dannjjm 3886 8 parasite parasite NN cord-023095-4dannjjm 3886 9 positive positive JJ cord-023095-4dannjjm 3886 10 fecal fecal JJ cord-023095-4dannjjm 3886 11 specimens specimen NNS cord-023095-4dannjjm 3886 12 consisting consist VBG cord-023095-4dannjjm 3886 13 of of IN cord-023095-4dannjjm 3886 14 90 90 CD cord-023095-4dannjjm 3886 15 canine canine NN cord-023095-4dannjjm 3886 16 , , , cord-023095-4dannjjm 3886 17 29 29 CD cord-023095-4dannjjm 3886 18 feline feline NN cord-023095-4dannjjm 3886 19 , , , cord-023095-4dannjjm 3886 20 14 14 CD cord-023095-4dannjjm 3886 21 equine equine NN cord-023095-4dannjjm 3886 22 and and CC cord-023095-4dannjjm 3886 23 2 2 CD cord-023095-4dannjjm 3886 24 from from IN cord-023095-4dannjjm 3886 25 other other JJ cord-023095-4dannjjm 3886 26 host host NN cord-023095-4dannjjm 3886 27 species specie NNS cord-023095-4dannjjm 3886 28 , , , cord-023095-4dannjjm 3886 29 comparing compare VBG cord-023095-4dannjjm 3886 30 recovery recovery NN cord-023095-4dannjjm 3886 31 of of IN cord-023095-4dannjjm 3886 32 eggs egg NNS cord-023095-4dannjjm 3886 33 , , , cord-023095-4dannjjm 3886 34 protozoan protozoan NN cord-023095-4dannjjm 3886 35 cysts cyst NNS cord-023095-4dannjjm 3886 36 and and CC cord-023095-4dannjjm 3886 37 coccidian coccidian NN cord-023095-4dannjjm 3886 38 oocysts oocyst NNS cord-023095-4dannjjm 3886 39 using use VBG cord-023095-4dannjjm 3886 40 2 2 CD cord-023095-4dannjjm 3886 41 standardized standardized JJ cord-023095-4dannjjm 3886 42 methods method NNS cord-023095-4dannjjm 3886 43 of of IN cord-023095-4dannjjm 3886 44 parasite parasite NN cord-023095-4dannjjm 3886 45 concentration concentration NN cord-023095-4dannjjm 3886 46 : : : cord-023095-4dannjjm 3886 47 the the DT cord-023095-4dannjjm 3886 48 formalin formalin NN cord-023095-4dannjjm 3886 49 / / SYM cord-023095-4dannjjm 3886 50 ethyl ethyl NN cord-023095-4dannjjm 3886 51 acetate acetate NN cord-023095-4dannjjm 3886 52 ( ( -LRB- cord-023095-4dannjjm 3886 53 F F NNP cord-023095-4dannjjm 3886 54 / / SYM cord-023095-4dannjjm 3886 55 EA EA NNP cord-023095-4dannjjm 3886 56 ) ) -RRB- cord-023095-4dannjjm 3886 57 sedimentation sedimentation NN cord-023095-4dannjjm 3886 58 concentration concentration NN cord-023095-4dannjjm 3886 59 and and CC cord-023095-4dannjjm 3886 60 the the DT cord-023095-4dannjjm 3886 61 commercial commercial JJ cord-023095-4dannjjm 3886 62 Fecalyzer Fecalyzer NNP cord-023095-4dannjjm 3886 63 ( ( -LRB- cord-023095-4dannjjm 3886 64 flotation flotation NN cord-023095-4dannjjm 3886 65 ) ) -RRB- cord-023095-4dannjjm 3886 66 kit kit NN cord-023095-4dannjjm 3886 67 procedures procedure NNS cord-023095-4dannjjm 3886 68 . . . cord-023095-4dannjjm 3887 1 Specimens specimen NNS cord-023095-4dannjjm 3887 2 were be VBD cord-023095-4dannjjm 3887 3 processed process VBN cord-023095-4dannjjm 3887 4 by by IN cord-023095-4dannjjm 3887 5 each each DT cord-023095-4dannjjm 3887 6 technique technique NN cord-023095-4dannjjm 3887 7 either either CC cord-023095-4dannjjm 3887 8 according accord VBG cord-023095-4dannjjm 3887 9 to to IN cord-023095-4dannjjm 3887 10 manufacturer manufacturer NN cord-023095-4dannjjm 3887 11 's 's POS cord-023095-4dannjjm 3887 12 instructions instruction NNS cord-023095-4dannjjm 3887 13 or or CC cord-023095-4dannjjm 3887 14 according accord VBG cord-023095-4dannjjm 3887 15 to to IN cord-023095-4dannjjm 3887 16 standard standard JJ cord-023095-4dannjjm 3887 17 laboratory laboratory NN cord-023095-4dannjjm 3887 18 procedures procedure NNS cord-023095-4dannjjm 3887 19 . . . cord-023095-4dannjjm 3888 1 Formalin Formalin NNP cord-023095-4dannjjm 3888 2 / / SYM cord-023095-4dannjjm 3888 3 ethyl ethyl NN cord-023095-4dannjjm 3888 4 acetate acetate NN cord-023095-4dannjjm 3888 5 concentrations concentration NNS cord-023095-4dannjjm 3888 6 used use VBN cord-023095-4dannjjm 3888 7 at at IN cord-023095-4dannjjm 3888 8 a a DT cord-023095-4dannjjm 3888 9 ratio ratio NN cord-023095-4dannjjm 3888 10 of of IN cord-023095-4dannjjm 3888 11 10 10 CD cord-023095-4dannjjm 3888 12 ml ml NN cord-023095-4dannjjm 3888 13 normal normal JJ cord-023095-4dannjjm 3888 14 saline saline NN cord-023095-4dannjjm 3888 15 to to IN cord-023095-4dannjjm 3888 16 4 4 CD cord-023095-4dannjjm 3888 17 ml ml NN cord-023095-4dannjjm 3888 18 ethyl ethyl NN cord-023095-4dannjjm 3888 19 acetate acetate NN cord-023095-4dannjjm 3888 20 for for IN cord-023095-4dannjjm 3888 21 extraction extraction NN cord-023095-4dannjjm 3888 22 of of IN cord-023095-4dannjjm 3888 23 lipophilic lipophilic JJ cord-023095-4dannjjm 3888 24 material material NN cord-023095-4dannjjm 3888 25 from from IN cord-023095-4dannjjm 3888 26 pelleted pelleted JJ cord-023095-4dannjjm 3888 27 stool stool NN cord-023095-4dannjjm 3888 28 samples sample NNS cord-023095-4dannjjm 3888 29 , , , cord-023095-4dannjjm 3888 30 previously previously RB cord-023095-4dannjjm 3888 31 fixed fix VBN cord-023095-4dannjjm 3888 32 in in IN cord-023095-4dannjjm 3888 33 sodium sodium NN cord-023095-4dannjjm 3888 34 acetate acetate NN cord-023095-4dannjjm 3888 35 / / SYM cord-023095-4dannjjm 3888 36 acetic acetic JJ cord-023095-4dannjjm 3888 37 / / SYM cord-023095-4dannjjm 3888 38 acid acid NN cord-023095-4dannjjm 3888 39 / / SYM cord-023095-4dannjjm 3888 40 formalin formalin NN cord-023095-4dannjjm 3888 41 ( ( -LRB- cord-023095-4dannjjm 3888 42 SAF SAF NNP cord-023095-4dannjjm 3888 43 ) ) -RRB- cord-023095-4dannjjm 3888 44 solution solution NN cord-023095-4dannjjm 3888 45 . . . cord-023095-4dannjjm 3889 1 Flotations flotation NNS cord-023095-4dannjjm 3889 2 with with IN cord-023095-4dannjjm 3889 3 the the DT cord-023095-4dannjjm 3889 4 Fecalyzer Fecalyzer NNP cord-023095-4dannjjm 3889 5 kit kit NN cord-023095-4dannjjm 3889 6 were be VBD cord-023095-4dannjjm 3889 7 performed perform VBN cord-023095-4dannjjm 3889 8 with with IN cord-023095-4dannjjm 3889 9 concentrated concentrated JJ cord-023095-4dannjjm 3889 10 zinc zinc NN cord-023095-4dannjjm 3889 11 sulfate sulfate NN cord-023095-4dannjjm 3889 12 solution solution NN cord-023095-4dannjjm 3889 13 ( ( -LRB- cord-023095-4dannjjm 3889 14 s. s. NNP cord-023095-4dannjjm 3889 15 g. g. NNP cord-023095-4dannjjm 3889 16 1.22 1.22 CD cord-023095-4dannjjm 3889 17 ) ) -RRB- cord-023095-4dannjjm 3889 18 . . . cord-023095-4dannjjm 3890 1 The the DT cord-023095-4dannjjm 3890 2 range range NN cord-023095-4dannjjm 3890 3 of of IN cord-023095-4dannjjm 3890 4 parasites parasite NNS cord-023095-4dannjjm 3890 5 recovered recover VBN cord-023095-4dannjjm 3890 6 from from IN cord-023095-4dannjjm 3890 7 these these DT cord-023095-4dannjjm 3890 8 specimens specimen NNS cord-023095-4dannjjm 3890 9 included include VBN cord-023095-4dannjjm 3890 10 flagellate flagellate VBP cord-023095-4dannjjm 3890 11 cysts cyst NNS cord-023095-4dannjjm 3890 12 ( ( -LRB- cord-023095-4dannjjm 3890 13 40 40 CD cord-023095-4dannjjm 3890 14 total total NN cord-023095-4dannjjm 3890 15 ) ) -RRB- cord-023095-4dannjjm 3890 16 , , , cord-023095-4dannjjm 3890 17 coccidian coccidian NNP cord-023095-4dannjjm 3890 18 oocysts oocyst NNS cord-023095-4dannjjm 3890 19 ( ( -LRB- cord-023095-4dannjjm 3890 20 28 28 CD cord-023095-4dannjjm 3890 21 total total NN cord-023095-4dannjjm 3890 22 ) ) -RRB- cord-023095-4dannjjm 3890 23 , , , cord-023095-4dannjjm 3890 24 ova ova NN cord-023095-4dannjjm 3890 25 and and CC cord-023095-4dannjjm 3890 26 larvae larva NNS cord-023095-4dannjjm 3890 27 of of IN cord-023095-4dannjjm 3890 28 nematodes nematode NNS cord-023095-4dannjjm 3890 29 ( ( -LRB- cord-023095-4dannjjm 3890 30 80 80 CD cord-023095-4dannjjm 3890 31 total total NN cord-023095-4dannjjm 3890 32 ) ) -RRB- cord-023095-4dannjjm 3890 33 , , , cord-023095-4dannjjm 3890 34 and and CC cord-023095-4dannjjm 3890 35 ova ova NN cord-023095-4dannjjm 3890 36 of of IN cord-023095-4dannjjm 3890 37 trematodes trematode NNS cord-023095-4dannjjm 3890 38 ( ( -LRB- cord-023095-4dannjjm 3890 39 12 12 CD cord-023095-4dannjjm 3890 40 total total NN cord-023095-4dannjjm 3890 41 ) ) -RRB- cord-023095-4dannjjm 3890 42 , , , cord-023095-4dannjjm 3890 43 and and CC cord-023095-4dannjjm 3890 44 cestodes cestodes NNP cord-023095-4dannjjm 3890 45 ( ( -LRB- cord-023095-4dannjjm 3890 46 16 16 CD cord-023095-4dannjjm 3890 47 total total NN cord-023095-4dannjjm 3890 48 ) ) -RRB- cord-023095-4dannjjm 3890 49 . . . cord-023095-4dannjjm 3891 1 Recovery recovery NN cord-023095-4dannjjm 3891 2 rates rate NNS cord-023095-4dannjjm 3891 3 by by IN cord-023095-4dannjjm 3891 4 Fecalyzer Fecalyzer NNP cord-023095-4dannjjm 3891 5 flotation flotation NN cord-023095-4dannjjm 3891 6 were be VBD cord-023095-4dannjjm 3891 7 good good JJ cord-023095-4dannjjm 3891 8 for for IN cord-023095-4dannjjm 3891 9 protozoan protozoan NN cord-023095-4dannjjm 3891 10 cysts cyst NNS cord-023095-4dannjjm 3891 11 , , , cord-023095-4dannjjm 3891 12 coccidian coccidian JJ cord-023095-4dannjjm 3891 13 oocysts oocyst NNS cord-023095-4dannjjm 3891 14 and and CC cord-023095-4dannjjm 3891 15 nematode nematode NN cord-023095-4dannjjm 3891 16 eggs egg NNS cord-023095-4dannjjm 3891 17 and and CC cord-023095-4dannjjm 3891 18 larvae larva NNS cord-023095-4dannjjm 3891 19 , , , cord-023095-4dannjjm 3891 20 but but CC cord-023095-4dannjjm 3891 21 very very RB cord-023095-4dannjjm 3891 22 poor poor JJ cord-023095-4dannjjm 3891 23 for for IN cord-023095-4dannjjm 3891 24 cestode cestode NN cord-023095-4dannjjm 3891 25 and and CC cord-023095-4dannjjm 3891 26 trematode trematode NN cord-023095-4dannjjm 3891 27 eggs egg NNS cord-023095-4dannjjm 3891 28 . . . cord-023095-4dannjjm 3892 1 Formalin Formalin NNP cord-023095-4dannjjm 3892 2 / / SYM cord-023095-4dannjjm 3892 3 ethyl ethyl NN cord-023095-4dannjjm 3893 1 acetate acetate NN cord-023095-4dannjjm 3893 2 concentration concentration NN cord-023095-4dannjjm 3893 3 showed show VBD cord-023095-4dannjjm 3893 4 excellent excellent JJ cord-023095-4dannjjm 3893 5 recovery recovery NN cord-023095-4dannjjm 3893 6 of of IN cord-023095-4dannjjm 3893 7 all all DT cord-023095-4dannjjm 3893 8 parasites parasite NNS cord-023095-4dannjjm 3893 9 and and CC cord-023095-4dannjjm 3893 10 consistently consistently RB cord-023095-4dannjjm 3893 11 outperformed outperform VBD cord-023095-4dannjjm 3893 12 Fecalyzer Fecalyzer NNP cord-023095-4dannjjm 3893 13 in in IN cord-023095-4dannjjm 3893 14 recovery recovery NN cord-023095-4dannjjm 3893 15 rates rate NNS cord-023095-4dannjjm 3893 16 . . . cord-023095-4dannjjm 3894 1 Recoveries recovery NNS cord-023095-4dannjjm 3894 2 by by IN cord-023095-4dannjjm 3894 3 F F NNP cord-023095-4dannjjm 3894 4 / / SYM cord-023095-4dannjjm 3894 5 EA EA NNP cord-023095-4dannjjm 3894 6 concentrations concentration NNS cord-023095-4dannjjm 3894 7 were be VBD cord-023095-4dannjjm 3894 8 higher high JJR cord-023095-4dannjjm 3894 9 by by IN cord-023095-4dannjjm 3894 10 27.5 27.5 CD cord-023095-4dannjjm 3894 11 % % NN cord-023095-4dannjjm 3894 12 for for IN cord-023095-4dannjjm 3894 13 Giardia Giardia NNP cord-023095-4dannjjm 3894 14 , , , cord-023095-4dannjjm 3894 15 by by IN cord-023095-4dannjjm 3894 16 10.7 10.7 CD cord-023095-4dannjjm 3894 17 % % NN cord-023095-4dannjjm 3894 18 for for IN cord-023095-4dannjjm 3894 19 coccidia coccidia NN cord-023095-4dannjjm 3894 20 and and CC cord-023095-4dannjjm 3894 21 by by IN cord-023095-4dannjjm 3894 22 10.0 10.0 CD cord-023095-4dannjjm 3894 23 % % NN cord-023095-4dannjjm 3894 24 for for IN cord-023095-4dannjjm 3894 25 nematode nematode NN cord-023095-4dannjjm 3894 26 eggs egg NNS cord-023095-4dannjjm 3894 27 and and CC cord-023095-4dannjjm 3894 28 larvae larva NNS cord-023095-4dannjjm 3894 29 . . . cord-023095-4dannjjm 3895 1 With with IN cord-023095-4dannjjm 3895 2 the the DT cord-023095-4dannjjm 3895 3 exception exception NN cord-023095-4dannjjm 3895 4 of of IN cord-023095-4dannjjm 3895 5 coccidian coccidian JJ cord-023095-4dannjjm 3895 6 oocysts oocyst NNS cord-023095-4dannjjm 3895 7 , , , cord-023095-4dannjjm 3895 8 based base VBN cord-023095-4dannjjm 3895 9 on on IN cord-023095-4dannjjm 3895 10 Z z NN cord-023095-4dannjjm 3895 11 - - HYPH cord-023095-4dannjjm 3895 12 test test NN cord-023095-4dannjjm 3895 13 analyses analysis NNS cord-023095-4dannjjm 3895 14 , , , cord-023095-4dannjjm 3895 15 recovery recovery NN cord-023095-4dannjjm 3895 16 rates rate NNS cord-023095-4dannjjm 3895 17 were be VBD cord-023095-4dannjjm 3895 18 significantly significantly RB cord-023095-4dannjjm 3895 19 higher high JJR cord-023095-4dannjjm 3895 20 , , , cord-023095-4dannjjm 3895 21 at at IN cord-023095-4dannjjm 3895 22 a a DT cord-023095-4dannjjm 3895 23 confidence confidence NN cord-023095-4dannjjm 3895 24 level level NN cord-023095-4dannjjm 3895 25 of of IN cord-023095-4dannjjm 3895 26 at at RB cord-023095-4dannjjm 3895 27 least least RBS cord-023095-4dannjjm 3895 28 95 95 CD cord-023095-4dannjjm 3895 29 % % NN cord-023095-4dannjjm 3895 30 , , , cord-023095-4dannjjm 3895 31 for for IN cord-023095-4dannjjm 3895 32 all all DT cord-023095-4dannjjm 3895 33 parasites parasite NNS cord-023095-4dannjjm 3895 34 , , , cord-023095-4dannjjm 3895 35 using use VBG cord-023095-4dannjjm 3895 36 formalin formalin NN cord-023095-4dannjjm 3895 37 / / SYM cord-023095-4dannjjm 3895 38 ethyl ethyl NN cord-023095-4dannjjm 3895 39 acetate acetate NN cord-023095-4dannjjm 3895 40 sedimentation sedimentation NN cord-023095-4dannjjm 3895 41 concentration concentration NN cord-023095-4dannjjm 3895 42 . . . cord-023095-4dannjjm 3896 1 Although although IN cord-023095-4dannjjm 3896 2 CAPC CAPC NNP cord-023095-4dannjjm 3896 3 recommends recommend VBZ cord-023095-4dannjjm 3896 4 the the DT cord-023095-4dannjjm 3896 5 use use NN cord-023095-4dannjjm 3896 6 of of IN cord-023095-4dannjjm 3896 7 flotation flotation NN cord-023095-4dannjjm 3896 8 with with IN cord-023095-4dannjjm 3896 9 centrifugation centrifugation NN cord-023095-4dannjjm 3896 10 methods method NNS cord-023095-4dannjjm 3896 11 for for IN cord-023095-4dannjjm 3896 12 standard standard JJ cord-023095-4dannjjm 3896 13 fecal fecal JJ cord-023095-4dannjjm 3896 14 ova ova NN cord-023095-4dannjjm 3896 15 and and CC cord-023095-4dannjjm 3896 16 parasite parasite NN cord-023095-4dannjjm 3896 17 examination examination NN cord-023095-4dannjjm 3896 18 for for IN cord-023095-4dannjjm 3896 19 veterinary veterinary JJ cord-023095-4dannjjm 3896 20 patients patient NNS cord-023095-4dannjjm 3896 21 , , , cord-023095-4dannjjm 3896 22 sedimentation sedimentation NN cord-023095-4dannjjm 3896 23 concentration concentration NN cord-023095-4dannjjm 3896 24 methods method NNS cord-023095-4dannjjm 3896 25 are be VBP cord-023095-4dannjjm 3896 26 widely widely RB cord-023095-4dannjjm 3896 27 and and CC cord-023095-4dannjjm 3896 28 effectively effectively RB cord-023095-4dannjjm 3896 29 used use VBN cord-023095-4dannjjm 3896 30 in in IN cord-023095-4dannjjm 3896 31 human human JJ cord-023095-4dannjjm 3896 32 diagnostic diagnostic JJ cord-023095-4dannjjm 3896 33 parasitology parasitology NN cord-023095-4dannjjm 3896 34 laboratories laboratory NNS cord-023095-4dannjjm 3896 35 . . . cord-023095-4dannjjm 3897 1 These these DT cord-023095-4dannjjm 3897 2 results result NNS cord-023095-4dannjjm 3897 3 provide provide VBP cord-023095-4dannjjm 3897 4 good good JJ cord-023095-4dannjjm 3897 5 evidence evidence NN cord-023095-4dannjjm 3897 6 for for IN cord-023095-4dannjjm 3897 7 the the DT cord-023095-4dannjjm 3897 8 use use NN cord-023095-4dannjjm 3897 9 of of IN cord-023095-4dannjjm 3897 10 F F NNP cord-023095-4dannjjm 3897 11 / / SYM cord-023095-4dannjjm 3897 12 EA EA NNP cord-023095-4dannjjm 3897 13 concentration concentration NN cord-023095-4dannjjm 3897 14 as as IN cord-023095-4dannjjm 3897 15 a a DT cord-023095-4dannjjm 3897 16 preferred preferred JJ cord-023095-4dannjjm 3897 17 method method NN cord-023095-4dannjjm 3897 18 to to IN cord-023095-4dannjjm 3897 19 flotation flotation NN cord-023095-4dannjjm 3897 20 procedures procedure NNS cord-023095-4dannjjm 3897 21 for for IN cord-023095-4dannjjm 3897 22 stool stool NN cord-023095-4dannjjm 3897 23 ova ova NN cord-023095-4dannjjm 3897 24 and and CC cord-023095-4dannjjm 3897 25 parasite parasite NN cord-023095-4dannjjm 3897 26 examinations examination NNS cord-023095-4dannjjm 3897 27 in in IN cord-023095-4dannjjm 3897 28 veterinary veterinary JJ cord-023095-4dannjjm 3897 29 laboratories laboratory NNS cord-023095-4dannjjm 3897 30 . . . cord-023095-4dannjjm 3898 1 Cyclosporine cyclosporine NN cord-023095-4dannjjm 3898 2 and and CC cord-023095-4dannjjm 3898 3 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 3898 4 are be VBP cord-023095-4dannjjm 3898 5 powerful powerful JJ cord-023095-4dannjjm 3898 6 immunosuppressive immunosuppressive JJ cord-023095-4dannjjm 3898 7 agents agent NNS cord-023095-4dannjjm 3898 8 used use VBN cord-023095-4dannjjm 3898 9 to to TO cord-023095-4dannjjm 3898 10 treat treat VB cord-023095-4dannjjm 3898 11 many many JJ cord-023095-4dannjjm 3898 12 inflammatory inflammatory JJ cord-023095-4dannjjm 3898 13 diseases disease NNS cord-023095-4dannjjm 3898 14 . . . cord-023095-4dannjjm 3899 1 Cyclosporine cyclosporine NN cord-023095-4dannjjm 3899 2 inhibits inhibit VBZ cord-023095-4dannjjm 3899 3 calcineurin calcineurin NN cord-023095-4dannjjm 3899 4 - - HYPH cord-023095-4dannjjm 3899 5 dependent dependent JJ cord-023095-4dannjjm 3899 6 pathways pathway NNS cord-023095-4dannjjm 3899 7 of of IN cord-023095-4dannjjm 3899 8 T t NN cord-023095-4dannjjm 3899 9 - - HYPH cord-023095-4dannjjm 3899 10 cell cell NN cord-023095-4dannjjm 3899 11 activation activation NN cord-023095-4dannjjm 3899 12 and and CC cord-023095-4dannjjm 3899 13 the the DT cord-023095-4dannjjm 3899 14 resultant resultant JJ cord-023095-4dannjjm 3899 15 cytokine cytokine NN cord-023095-4dannjjm 3899 16 production production NN cord-023095-4dannjjm 3899 17 , , , cord-023095-4dannjjm 3899 18 and and CC cord-023095-4dannjjm 3899 19 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 3899 20 directly directly RB cord-023095-4dannjjm 3899 21 inhibit inhibit VBP cord-023095-4dannjjm 3899 22 genes gene NNS cord-023095-4dannjjm 3899 23 coding code VBG cord-023095-4dannjjm 3899 24 for for IN cord-023095-4dannjjm 3899 25 cytokines cytokine NNS cord-023095-4dannjjm 3899 26 . . . cord-023095-4dannjjm 3900 1 Little little JJ cord-023095-4dannjjm 3900 2 work work NN cord-023095-4dannjjm 3900 3 has have VBZ cord-023095-4dannjjm 3900 4 been be VBN cord-023095-4dannjjm 3900 5 done do VBN cord-023095-4dannjjm 3900 6 comparing compare VBG cord-023095-4dannjjm 3900 7 the the DT cord-023095-4dannjjm 3900 8 effects effect NNS cord-023095-4dannjjm 3900 9 of of IN cord-023095-4dannjjm 3900 10 these these DT cord-023095-4dannjjm 3900 11 agents agent NNS cord-023095-4dannjjm 3900 12 on on IN cord-023095-4dannjjm 3900 13 cytokine cytokine NN cord-023095-4dannjjm 3900 14 production production NN cord-023095-4dannjjm 3900 15 in in IN cord-023095-4dannjjm 3900 16 dogs dog NNS cord-023095-4dannjjm 3900 17 . . . cord-023095-4dannjjm 3901 1 Our -PRON- PRP$ cord-023095-4dannjjm 3901 2 study study NN cord-023095-4dannjjm 3901 3 assessed assess VBD cord-023095-4dannjjm 3901 4 these these DT cord-023095-4dannjjm 3901 5 effects effect NNS cord-023095-4dannjjm 3901 6 by by IN cord-023095-4dannjjm 3901 7 measuring measure VBG cord-023095-4dannjjm 3901 8 T t NN cord-023095-4dannjjm 3901 9 - - HYPH cord-023095-4dannjjm 3901 10 cell cell NN cord-023095-4dannjjm 3901 11 cytokine cytokine NN cord-023095-4dannjjm 3901 12 production production NN cord-023095-4dannjjm 3901 13 using use VBG cord-023095-4dannjjm 3901 14 flow flow NN cord-023095-4dannjjm 3901 15 cytometry cytometry NN cord-023095-4dannjjm 3901 16 , , , cord-023095-4dannjjm 3901 17 and and CC cord-023095-4dannjjm 3901 18 cytokine cytokine NN cord-023095-4dannjjm 3901 19 gene gene NN cord-023095-4dannjjm 3901 20 expression expression NN cord-023095-4dannjjm 3901 21 using use VBG cord-023095-4dannjjm 3901 22 quantitative quantitative JJ cord-023095-4dannjjm 3901 23 reverse reverse JJ cord-023095-4dannjjm 3901 24 transcriptase transcriptase NN cord-023095-4dannjjm 3901 25 polymerase polymerase NN cord-023095-4dannjjm 3901 26 chain chain NN cord-023095-4dannjjm 3901 27 reaction reaction NN cord-023095-4dannjjm 3901 28 ( ( -LRB- cord-023095-4dannjjm 3901 29 qRT qRT NNP cord-023095-4dannjjm 3901 30 - - HYPH cord-023095-4dannjjm 3901 31 PCR PCR NNP cord-023095-4dannjjm 3901 32 ) ) -RRB- cord-023095-4dannjjm 3901 33 in in IN cord-023095-4dannjjm 3901 34 activated activate VBN cord-023095-4dannjjm 3901 35 canine canine JJ cord-023095-4dannjjm 3901 36 T T NNP cord-023095-4dannjjm 3901 37 - - HYPH cord-023095-4dannjjm 3901 38 cells cell NNS cord-023095-4dannjjm 3901 39 treated treat VBN cord-023095-4dannjjm 3901 40 with with IN cord-023095-4dannjjm 3901 41 cyclosporine cyclosporine NN cord-023095-4dannjjm 3901 42 and and CC cord-023095-4dannjjm 3901 43 dexamethasone dexamethasone NN cord-023095-4dannjjm 3901 44 . . . cord-023095-4dannjjm 3902 1 For for IN cord-023095-4dannjjm 3902 2 flow flow NN cord-023095-4dannjjm 3902 3 cytometric cytometric NN cord-023095-4dannjjm 3902 4 assays assay NNS cord-023095-4dannjjm 3902 5 , , , cord-023095-4dannjjm 3902 6 peripheral peripheral JJ cord-023095-4dannjjm 3902 7 blood blood NN cord-023095-4dannjjm 3902 8 mononuclear mononuclear NN cord-023095-4dannjjm 3902 9 cells cell NNS cord-023095-4dannjjm 3902 10 were be VBD cord-023095-4dannjjm 3902 11 separated separate VBN cord-023095-4dannjjm 3902 12 using use VBG cord-023095-4dannjjm 3902 13 density density NN cord-023095-4dannjjm 3902 14 gradients gradient NNS cord-023095-4dannjjm 3902 15 and and CC cord-023095-4dannjjm 3902 16 cultured culture VBN cord-023095-4dannjjm 3902 17 for for IN cord-023095-4dannjjm 3902 18 12 12 CD cord-023095-4dannjjm 3902 19 hours hour NNS cord-023095-4dannjjm 3902 20 in in IN cord-023095-4dannjjm 3902 21 the the DT cord-023095-4dannjjm 3902 22 presence presence NN cord-023095-4dannjjm 3902 23 of of IN cord-023095-4dannjjm 3902 24 cyclosporine cyclosporine NN cord-023095-4dannjjm 3902 25 ( ( -LRB- cord-023095-4dannjjm 3902 26 5 5 CD cord-023095-4dannjjm 3902 27 , , , cord-023095-4dannjjm 3902 28 25 25 CD cord-023095-4dannjjm 3902 29 , , , cord-023095-4dannjjm 3902 30 or or CC cord-023095-4dannjjm 3902 31 100 100 CD cord-023095-4dannjjm 3902 32 ng ng NN cord-023095-4dannjjm 3902 33 / / SYM cord-023095-4dannjjm 3902 34 mL mL NNP cord-023095-4dannjjm 3902 35 ) ) -RRB- cord-023095-4dannjjm 3902 36 , , , cord-023095-4dannjjm 3902 37 dexamethasone dexamethasone NN cord-023095-4dannjjm 3902 38 ( ( -LRB- cord-023095-4dannjjm 3902 39 10 10 CD cord-023095-4dannjjm 3902 40 À7 À7 NNP cord-023095-4dannjjm 3902 41 , , , cord-023095-4dannjjm 3902 42 10 10 CD cord-023095-4dannjjm 3902 43 À6 à6 CD cord-023095-4dannjjm 3902 44 , , , cord-023095-4dannjjm 3902 45 10 10 CD cord-023095-4dannjjm 3902 46 À5 À5 NNP cord-023095-4dannjjm 3902 47 M M NNP cord-023095-4dannjjm 3902 48 ) ) -RRB- cord-023095-4dannjjm 3902 49 , , , cord-023095-4dannjjm 3902 50 or or CC cord-023095-4dannjjm 3902 51 cyclosporine cyclosporine NN cord-023095-4dannjjm 3902 52 plus plus CC cord-023095-4dannjjm 3902 53 dexamethasone dexamethasone NN cord-023095-4dannjjm 3902 54 . . . cord-023095-4dannjjm 3903 1 For for IN cord-023095-4dannjjm 3903 2 qRT qRT NNP cord-023095-4dannjjm 3903 3 - - HYPH cord-023095-4dannjjm 3903 4 PCR PCR NNP cord-023095-4dannjjm 3903 5 , , , cord-023095-4dannjjm 3903 6 whole whole JJ cord-023095-4dannjjm 3903 7 blood blood NN cord-023095-4dannjjm 3903 8 was be VBD cord-023095-4dannjjm 3903 9 cultured culture VBN cord-023095-4dannjjm 3903 10 for for IN cord-023095-4dannjjm 3903 11 5 5 CD cord-023095-4dannjjm 3903 12 hours hour NNS cord-023095-4dannjjm 3903 13 with with IN cord-023095-4dannjjm 3903 14 the the DT cord-023095-4dannjjm 3903 15 same same JJ cord-023095-4dannjjm 3903 16 drugs drug NNS cord-023095-4dannjjm 3903 17 at at IN cord-023095-4dannjjm 3903 18 the the DT cord-023095-4dannjjm 3903 19 same same JJ cord-023095-4dannjjm 3903 20 concentrations concentration NNS cord-023095-4dannjjm 3903 21 , , , cord-023095-4dannjjm 3903 22 and and CC cord-023095-4dannjjm 3903 23 RNA RNA NNP cord-023095-4dannjjm 3903 24 was be VBD cord-023095-4dannjjm 3903 25 then then RB cord-023095-4dannjjm 3903 26 extracted extract VBN cord-023095-4dannjjm 3903 27 from from IN cord-023095-4dannjjm 3903 28 leukocytes leukocyte NNS cord-023095-4dannjjm 3903 29 . . . cord-023095-4dannjjm 3904 1 Expression expression NN cord-023095-4dannjjm 3904 2 of of IN cord-023095-4dannjjm 3904 3 cytokines cytokine NNS cord-023095-4dannjjm 3904 4 IL-2 il-2 NN cord-023095-4dannjjm 3904 5 and and CC cord-023095-4dannjjm 3904 6 IFN IFN NNP cord-023095-4dannjjm 3904 7 - - HYPH cord-023095-4dannjjm 3904 8 g g NNP cord-023095-4dannjjm 3904 9 was be VBD cord-023095-4dannjjm 3904 10 analyzed analyze VBN cord-023095-4dannjjm 3904 11 in in IN cord-023095-4dannjjm 3904 12 PMA PMA NNP cord-023095-4dannjjm 3904 13 / / SYM cord-023095-4dannjjm 3904 14 ionomycinactivated ionomycinactivate VBN cord-023095-4dannjjm 3904 15 T T NNP cord-023095-4dannjjm 3904 16 - - HYPH cord-023095-4dannjjm 3904 17 cells cell NNS cord-023095-4dannjjm 3904 18 by by IN cord-023095-4dannjjm 3904 19 flow flow NN cord-023095-4dannjjm 3904 20 cytometry cytometry NN cord-023095-4dannjjm 3904 21 , , , cord-023095-4dannjjm 3904 22 and and CC cord-023095-4dannjjm 3904 23 gene gene NN cord-023095-4dannjjm 3904 24 expression expression NN cord-023095-4dannjjm 3904 25 for for IN cord-023095-4dannjjm 3904 26 IL-2 IL-2 NNP cord-023095-4dannjjm 3904 27 and and CC cord-023095-4dannjjm 3904 28 IFN IFN NNP cord-023095-4dannjjm 3904 29 - - HYPH cord-023095-4dannjjm 3904 30 g g NNP cord-023095-4dannjjm 3904 31 in in IN cord-023095-4dannjjm 3904 32 activated activate VBN cord-023095-4dannjjm 3904 33 T t NN cord-023095-4dannjjm 3904 34 - - HYPH cord-023095-4dannjjm 3904 35 cell cell NN cord-023095-4dannjjm 3904 36 populations population NNS cord-023095-4dannjjm 3904 37 was be VBD cord-023095-4dannjjm 3904 38 assessed assess VBN cord-023095-4dannjjm 3904 39 via via IN cord-023095-4dannjjm 3904 40 qRT qrt ADD cord-023095-4dannjjm 3904 41 - - HYPH cord-023095-4dannjjm 3904 42 PCR PCR NNP cord-023095-4dannjjm 3904 43 . . . cord-023095-4dannjjm 3905 1 Flow flow NN cord-023095-4dannjjm 3905 2 cytometry cytometry NN cord-023095-4dannjjm 3905 3 and and CC cord-023095-4dannjjm 3905 4 qRT qRT NNP cord-023095-4dannjjm 3905 5 - - HYPH cord-023095-4dannjjm 3905 6 PCR PCR NNP cord-023095-4dannjjm 3905 7 both both DT cord-023095-4dannjjm 3905 8 demonstrated demonstrate VBD cord-023095-4dannjjm 3905 9 inhibition inhibition NN cord-023095-4dannjjm 3905 10 of of IN cord-023095-4dannjjm 3905 11 IL-2 IL-2 NNP cord-023095-4dannjjm 3905 12 and and CC cord-023095-4dannjjm 3905 13 IFN IFN NNP cord-023095-4dannjjm 3905 14 - - HYPH cord-023095-4dannjjm 3905 15 g g NNP cord-023095-4dannjjm 3905 16 that that WDT cord-023095-4dannjjm 3905 17 was be VBD cord-023095-4dannjjm 3905 18 generally generally RB cord-023095-4dannjjm 3905 19 dose dose NN cord-023095-4dannjjm 3905 20 - - HYPH cord-023095-4dannjjm 3905 21 dependent dependent JJ cord-023095-4dannjjm 3905 22 in in IN cord-023095-4dannjjm 3905 23 response response NN cord-023095-4dannjjm 3905 24 to to IN cord-023095-4dannjjm 3905 25 both both CC cord-023095-4dannjjm 3905 26 cyclosporine cyclosporine NN cord-023095-4dannjjm 3905 27 and and CC cord-023095-4dannjjm 3905 28 dexamethasone dexamethasone NN cord-023095-4dannjjm 3905 29 . . . cord-023095-4dannjjm 3906 1 Flow flow NN cord-023095-4dannjjm 3906 2 cytometry cytometry NN cord-023095-4dannjjm 3906 3 results result NNS cord-023095-4dannjjm 3906 4 from from IN cord-023095-4dannjjm 3906 5 the the DT cord-023095-4dannjjm 3906 6 average average NN cord-023095-4dannjjm 3906 7 of of IN cord-023095-4dannjjm 3906 8 samples sample NNS cord-023095-4dannjjm 3906 9 collected collect VBN cord-023095-4dannjjm 3906 10 from from IN cord-023095-4dannjjm 3906 11 3 3 CD cord-023095-4dannjjm 3906 12 different different JJ cord-023095-4dannjjm 3906 13 dogs dog NNS cord-023095-4dannjjm 3906 14 are be VBP cord-023095-4dannjjm 3906 15 shown show VBN cord-023095-4dannjjm 3906 16 in in IN cord-023095-4dannjjm 3906 17 Figure Figure NNP cord-023095-4dannjjm 3906 18 A a NN cord-023095-4dannjjm 3906 19 . . . cord-023095-4dannjjm 3907 1 Similar similar JJ cord-023095-4dannjjm 3907 2 results result NNS cord-023095-4dannjjm 3907 3 were be VBD cord-023095-4dannjjm 3907 4 achieved achieve VBN cord-023095-4dannjjm 3907 5 using use VBG cord-023095-4dannjjm 3907 6 qRT qrt ADD cord-023095-4dannjjm 3907 7 - - HYPH cord-023095-4dannjjm 3907 8 PCR PCR NNP cord-023095-4dannjjm 3907 9 ( ( -LRB- cord-023095-4dannjjm 3907 10 Figure figure NN cord-023095-4dannjjm 3907 11 B b NN cord-023095-4dannjjm 3907 12 ) ) -RRB- cord-023095-4dannjjm 3907 13 . . . cord-023095-4dannjjm 3908 1 Suppression suppression NN cord-023095-4dannjjm 3908 2 of of IN cord-023095-4dannjjm 3908 3 IL-2 IL-2 NNP cord-023095-4dannjjm 3908 4 and and CC cord-023095-4dannjjm 3908 5 IFN IFN NNP cord-023095-4dannjjm 3908 6 - - HYPH cord-023095-4dannjjm 3908 7 g g NNP cord-023095-4dannjjm 3908 8 in in IN cord-023095-4dannjjm 3908 9 activated activate VBN cord-023095-4dannjjm 3908 10 T T NNP cord-023095-4dannjjm 3908 11 - - HYPH cord-023095-4dannjjm 3908 12 cells cell NNS cord-023095-4dannjjm 3908 13 has have VBZ cord-023095-4dannjjm 3908 14 potential potential JJ cord-023095-4dannjjm 3908 15 as as IN cord-023095-4dannjjm 3908 16 an an DT cord-023095-4dannjjm 3908 17 indicator indicator NN cord-023095-4dannjjm 3908 18 of of IN cord-023095-4dannjjm 3908 19 the the DT cord-023095-4dannjjm 3908 20 efficacy efficacy NN cord-023095-4dannjjm 3908 21 of of IN cord-023095-4dannjjm 3908 22 cyclosporine cyclosporine NN cord-023095-4dannjjm 3908 23 and and CC cord-023095-4dannjjm 3908 24 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 3908 25 in in IN cord-023095-4dannjjm 3908 26 suppressing suppress VBG cord-023095-4dannjjm 3908 27 canine canine JJ cord-023095-4dannjjm 3908 28 T t NN cord-023095-4dannjjm 3908 29 - - HYPH cord-023095-4dannjjm 3908 30 cell cell NN cord-023095-4dannjjm 3908 31 function function NN cord-023095-4dannjjm 3908 32 in in IN cord-023095-4dannjjm 3908 33 vivo vivo NN cord-023095-4dannjjm 3908 34 , , , cord-023095-4dannjjm 3908 35 and and CC cord-023095-4dannjjm 3908 36 may may MD cord-023095-4dannjjm 3908 37 therefore therefore RB cord-023095-4dannjjm 3908 38 be be VB cord-023095-4dannjjm 3908 39 of of IN cord-023095-4dannjjm 3908 40 value value NN cord-023095-4dannjjm 3908 41 for for IN cord-023095-4dannjjm 3908 42 characterizing characterize VBG cord-023095-4dannjjm 3908 43 the the DT cord-023095-4dannjjm 3908 44 immunosuppression immunosuppression NN cord-023095-4dannjjm 3908 45 induced induce VBN cord-023095-4dannjjm 3908 46 by by IN cord-023095-4dannjjm 3908 47 these these DT cord-023095-4dannjjm 3908 48 drugs drug NNS cord-023095-4dannjjm 3908 49 in in IN cord-023095-4dannjjm 3908 50 clinical clinical JJ cord-023095-4dannjjm 3908 51 patients patient NNS cord-023095-4dannjjm 3908 52 . . . cord-023095-4dannjjm 3909 1 Idiopathic idiopathic JJ cord-023095-4dannjjm 3909 2 eosinophilic eosinophilic JJ cord-023095-4dannjjm 3909 3 diseases disease NNS cord-023095-4dannjjm 3909 4 are be VBP cord-023095-4dannjjm 3909 5 described describe VBN cord-023095-4dannjjm 3909 6 in in IN cord-023095-4dannjjm 3909 7 several several JJ cord-023095-4dannjjm 3909 8 breeds breed NNS cord-023095-4dannjjm 3909 9 , , , cord-023095-4dannjjm 3909 10 but but CC cord-023095-4dannjjm 3909 11 are be VBP cord-023095-4dannjjm 3909 12 over over IN cord-023095-4dannjjm 3909 13 represented represent VBN cord-023095-4dannjjm 3909 14 in in IN cord-023095-4dannjjm 3909 15 Rottweilers rottweiler NNS cord-023095-4dannjjm 3909 16 . . . cord-023095-4dannjjm 3910 1 The the DT cord-023095-4dannjjm 3910 2 immunopathogenesis immunopathogenesis NN cord-023095-4dannjjm 3910 3 of of IN cord-023095-4dannjjm 3910 4 idiopathic idiopathic JJ cord-023095-4dannjjm 3910 5 eosinophilic eosinophilic JJ cord-023095-4dannjjm 3910 6 disorders disorder NNS cord-023095-4dannjjm 3910 7 is be VBZ cord-023095-4dannjjm 3910 8 poorly poorly RB cord-023095-4dannjjm 3910 9 characterised characterise VBN cord-023095-4dannjjm 3910 10 . . . cord-023095-4dannjjm 3911 1 Studies study NNS cord-023095-4dannjjm 3911 2 in in IN cord-023095-4dannjjm 3911 3 people people NNS cord-023095-4dannjjm 3911 4 highlight highlight VBP cord-023095-4dannjjm 3911 5 the the DT cord-023095-4dannjjm 3911 6 importance importance NN cord-023095-4dannjjm 3911 7 of of IN cord-023095-4dannjjm 3911 8 cytokines cytokine NNS cord-023095-4dannjjm 3911 9 , , , cord-023095-4dannjjm 3911 10 particularly particularly RB cord-023095-4dannjjm 3911 11 interleukin-5 interleukin-5 NNP cord-023095-4dannjjm 3911 12 ( ( -LRB- cord-023095-4dannjjm 3911 13 IL-5 IL-5 NNP cord-023095-4dannjjm 3911 14 ) ) -RRB- cord-023095-4dannjjm 3911 15 , , , cord-023095-4dannjjm 3911 16 in in IN cord-023095-4dannjjm 3911 17 mediating mediate VBG cord-023095-4dannjjm 3911 18 eosinophil eosinophil JJ cord-023095-4dannjjm 3911 19 maturation maturation NN cord-023095-4dannjjm 3911 20 , , , cord-023095-4dannjjm 3911 21 differentiation differentiation NN cord-023095-4dannjjm 3911 22 , , , cord-023095-4dannjjm 3911 23 egress egress NN cord-023095-4dannjjm 3911 24 from from IN cord-023095-4dannjjm 3911 25 the the DT cord-023095-4dannjjm 3911 26 bone bone NN cord-023095-4dannjjm 3911 27 marrow marrow NN cord-023095-4dannjjm 3911 28 , , , cord-023095-4dannjjm 3911 29 migration migration NN cord-023095-4dannjjm 3911 30 and and CC cord-023095-4dannjjm 3911 31 polyclonal polyclonal JJ cord-023095-4dannjjm 3911 32 expansion expansion NN cord-023095-4dannjjm 3911 33 . . . cord-023095-4dannjjm 3912 1 Eotaxin-2 Eotaxin-2 NNP cord-023095-4dannjjm 3912 2 and and CC cord-023095-4dannjjm 3912 3 eotaxin-3 eotaxin-3 NNP cord-023095-4dannjjm 3912 4 also also RB cord-023095-4dannjjm 3912 5 appear appear VBP cord-023095-4dannjjm 3912 6 important important JJ cord-023095-4dannjjm 3912 7 for for IN cord-023095-4dannjjm 3912 8 induction induction NN cord-023095-4dannjjm 3912 9 of of IN cord-023095-4dannjjm 3912 10 chemotaxis chemotaxis NN cord-023095-4dannjjm 3912 11 and and CC cord-023095-4dannjjm 3912 12 release release NN cord-023095-4dannjjm 3912 13 of of IN cord-023095-4dannjjm 3912 14 reactive reactive JJ cord-023095-4dannjjm 3912 15 oxygen oxygen NN cord-023095-4dannjjm 3912 16 species specie NNS cord-023095-4dannjjm 3912 17 from from IN cord-023095-4dannjjm 3912 18 eosinophils eosinophil NNS cord-023095-4dannjjm 3912 19 . . . cord-023095-4dannjjm 3913 1 The the DT cord-023095-4dannjjm 3913 2 aim aim NN cord-023095-4dannjjm 3913 3 of of IN cord-023095-4dannjjm 3913 4 the the DT cord-023095-4dannjjm 3913 5 current current JJ cord-023095-4dannjjm 3913 6 study study NN cord-023095-4dannjjm 3913 7 was be VBD cord-023095-4dannjjm 3913 8 to to TO cord-023095-4dannjjm 3913 9 establish establish VB cord-023095-4dannjjm 3913 10 whether whether IN cord-023095-4dannjjm 3913 11 definable definable JJ cord-023095-4dannjjm 3913 12 differences difference NNS cord-023095-4dannjjm 3913 13 in in IN cord-023095-4dannjjm 3913 14 specific specific JJ cord-023095-4dannjjm 3913 15 cytokines cytokine NNS cord-023095-4dannjjm 3913 16 associated associate VBN cord-023095-4dannjjm 3913 17 with with IN cord-023095-4dannjjm 3913 18 mediation mediation NN cord-023095-4dannjjm 3913 19 of of IN cord-023095-4dannjjm 3913 20 eosinophil eosinophil JJ cord-023095-4dannjjm 3913 21 production production NN cord-023095-4dannjjm 3913 22 and and CC cord-023095-4dannjjm 3913 23 survival survival NN cord-023095-4dannjjm 3913 24 are be VBP cord-023095-4dannjjm 3913 25 present present JJ cord-023095-4dannjjm 3913 26 between between IN cord-023095-4dannjjm 3913 27 healthy healthy JJ cord-023095-4dannjjm 3913 28 Rottweilers Rottweilers NNPS cord-023095-4dannjjm 3913 29 , , , cord-023095-4dannjjm 3913 30 non non NNS cord-023095-4dannjjm 3913 31 - - JJ cord-023095-4dannjjm 3913 32 Rottweilers Rottweilers NNPS cord-023095-4dannjjm 3913 33 and and CC cord-023095-4dannjjm 3913 34 Rottweilers Rottweilers NNPS cord-023095-4dannjjm 3913 35 with with IN cord-023095-4dannjjm 3913 36 non non JJ cord-023095-4dannjjm 3913 37 - - JJ cord-023095-4dannjjm 3913 38 parasitic parasitic JJ cord-023095-4dannjjm 3913 39 eosinophilia eosinophilia NN cord-023095-4dannjjm 3913 40 . . . cord-023095-4dannjjm 3914 1 Secondly secondly RB cord-023095-4dannjjm 3914 2 , , , cord-023095-4dannjjm 3914 3 by by IN cord-023095-4dannjjm 3914 4 evaluating evaluate VBG cord-023095-4dannjjm 3914 5 cytokine cytokine NN cord-023095-4dannjjm 3914 6 profiles profile NNS cord-023095-4dannjjm 3914 7 the the DT cord-023095-4dannjjm 3914 8 study study NN cord-023095-4dannjjm 3914 9 aimed aim VBN cord-023095-4dannjjm 3914 10 to to TO cord-023095-4dannjjm 3914 11 improve improve VB cord-023095-4dannjjm 3914 12 understanding understanding NN cord-023095-4dannjjm 3914 13 of of IN cord-023095-4dannjjm 3914 14 the the DT cord-023095-4dannjjm 3914 15 pathophysiology pathophysiology NN cord-023095-4dannjjm 3914 16 of of IN cord-023095-4dannjjm 3914 17 eosinophilia eosinophilia NN cord-023095-4dannjjm 3914 18 therefore therefore RB cord-023095-4dannjjm 3914 19 assisting assist VBG cord-023095-4dannjjm 3914 20 development development NN cord-023095-4dannjjm 3914 21 of of IN cord-023095-4dannjjm 3914 22 potential potential JJ cord-023095-4dannjjm 3914 23 molecular molecular JJ cord-023095-4dannjjm 3914 24 treatment treatment NN cord-023095-4dannjjm 3914 25 options option NNS cord-023095-4dannjjm 3914 26 . . . cord-023095-4dannjjm 3915 1 Quantitative quantitative JJ cord-023095-4dannjjm 3915 2 real real JJ cord-023095-4dannjjm 3915 3 - - HYPH cord-023095-4dannjjm 3915 4 time time NN cord-023095-4dannjjm 3915 5 reverse reverse JJ cord-023095-4dannjjm 3915 6 transcriptase transcriptase NN cord-023095-4dannjjm 3915 7 polymerase polymerase NN cord-023095-4dannjjm 3915 8 chain chain NN cord-023095-4dannjjm 3915 9 reaction reaction NN cord-023095-4dannjjm 3915 10 ( ( -LRB- cord-023095-4dannjjm 3916 1 QRT QRT NNP cord-023095-4dannjjm 3916 2 - - HYPH cord-023095-4dannjjm 3916 3 PCR PCR NNP cord-023095-4dannjjm 3916 4 ) ) -RRB- cord-023095-4dannjjm 3916 5 assays assay NNS cord-023095-4dannjjm 3916 6 were be VBD cord-023095-4dannjjm 3916 7 used use VBN cord-023095-4dannjjm 3916 8 to to TO cord-023095-4dannjjm 3916 9 quantify quantify VB cord-023095-4dannjjm 3916 10 messenger messenger NN cord-023095-4dannjjm 3916 11 RNA RNA NNP cord-023095-4dannjjm 3916 12 ( ( -LRB- cord-023095-4dannjjm 3916 13 mRNA mrna NN cord-023095-4dannjjm 3916 14 ) ) -RRB- cord-023095-4dannjjm 3916 15 encoding encoding NN cord-023095-4dannjjm 3916 16 cytokines cytokine NNS cord-023095-4dannjjm 3916 17 IL-4 IL-4 NNP cord-023095-4dannjjm 3916 18 , , , cord-023095-4dannjjm 3916 19 IL-5 IL-5 NNP cord-023095-4dannjjm 3916 20 , , , cord-023095-4dannjjm 3916 21 IL-10 IL-10 NNP cord-023095-4dannjjm 3916 22 , , , cord-023095-4dannjjm 3916 23 IL-23p19 IL-23p19 NNP cord-023095-4dannjjm 3916 24 , , , cord-023095-4dannjjm 3916 25 IL-12p35 IL-12p35 NNP cord-023095-4dannjjm 3916 26 , , , cord-023095-4dannjjm 3916 27 IL-12p40 IL-12p40 NNP cord-023095-4dannjjm 3916 28 , , , cord-023095-4dannjjm 3916 29 IL-18 IL-18 NNP cord-023095-4dannjjm 3916 30 , , , cord-023095-4dannjjm 3916 31 interferon interferon NN cord-023095-4dannjjm 3916 32 gamma gamma NN cord-023095-4dannjjm 3916 33 ( ( -LRB- cord-023095-4dannjjm 3916 34 IFN IFN NNP cord-023095-4dannjjm 3916 35 - - HYPH cord-023095-4dannjjm 3916 36 g g NNP cord-023095-4dannjjm 3916 37 ) ) -RRB- cord-023095-4dannjjm 3916 38 and and CC cord-023095-4dannjjm 3916 39 chemokines chemokine NNS cord-023095-4dannjjm 3916 40 eotaxin-2 eotaxin-2 NNPS cord-023095-4dannjjm 3916 41 and and CC cord-023095-4dannjjm 3916 42 eotaxin-3 eotaxin-3 NNP cord-023095-4dannjjm 3916 43 from from IN cord-023095-4dannjjm 3916 44 peripheral peripheral JJ cord-023095-4dannjjm 3916 45 blood blood NN cord-023095-4dannjjm 3916 46 mononuclear mononuclear JJ cord-023095-4dannjjm 3916 47 cell cell NN cord-023095-4dannjjm 3916 48 ( ( -LRB- cord-023095-4dannjjm 3916 49 PMBC PMBC NNP cord-023095-4dannjjm 3916 50 ) ) -RRB- cord-023095-4dannjjm 3916 51 samples sample NNS cord-023095-4dannjjm 3916 52 obtained obtain VBN cord-023095-4dannjjm 3916 53 from from IN cord-023095-4dannjjm 3916 54 healthy healthy JJ cord-023095-4dannjjm 3916 55 non non JJ cord-023095-4dannjjm 3916 56 - - JJ cord-023095-4dannjjm 3916 57 Rottweiler rottweiler JJ cord-023095-4dannjjm 3916 58 dogs dog NNS cord-023095-4dannjjm 3916 59 with with IN cord-023095-4dannjjm 3916 60 normal normal JJ cord-023095-4dannjjm 3916 61 eosinophil eosinophil JJ cord-023095-4dannjjm 3916 62 counts count NNS cord-023095-4dannjjm 3916 63 ( ( -LRB- cord-023095-4dannjjm 3916 64 n n NN cord-023095-4dannjjm 3916 65 5 5 CD cord-023095-4dannjjm 3916 66 5 5 CD cord-023095-4dannjjm 3916 67 ) ) -RRB- cord-023095-4dannjjm 3916 68 and and CC cord-023095-4dannjjm 3916 69 Rottweilers rottweiler NNS cord-023095-4dannjjm 3916 70 with with IN cord-023095-4dannjjm 3916 71 normal normal JJ cord-023095-4dannjjm 3916 72 ( ( -LRB- cord-023095-4dannjjm 3916 73 n n NN cord-023095-4dannjjm 3916 74 5 5 CD cord-023095-4dannjjm 3916 75 6 6 CD cord-023095-4dannjjm 3916 76 ) ) -RRB- cord-023095-4dannjjm 3916 77 , , , cord-023095-4dannjjm 3916 78 mildly mildly RB cord-023095-4dannjjm 3916 79 increased increase VBN cord-023095-4dannjjm 3916 80 ( ( -LRB- cord-023095-4dannjjm 3916 81 n n NN cord-023095-4dannjjm 3916 82 5 5 CD cord-023095-4dannjjm 3916 83 7 7 CD cord-023095-4dannjjm 3916 84 ) ) -RRB- cord-023095-4dannjjm 3916 85 and and CC cord-023095-4dannjjm 3916 86 high high JJ cord-023095-4dannjjm 3916 87 ( ( -LRB- cord-023095-4dannjjm 3916 88 n n NN cord-023095-4dannjjm 3916 89 5 5 CD cord-023095-4dannjjm 3916 90 3 3 CD cord-023095-4dannjjm 3916 91 ) ) -RRB- cord-023095-4dannjjm 3917 1 eosinophil eosinophil JJ cord-023095-4dannjjm 3917 2 counts count VBZ cord-023095-4dannjjm 3917 3 . . . cord-023095-4dannjjm 3918 1 Quantification quantification NN cord-023095-4dannjjm 3918 2 of of IN cord-023095-4dannjjm 3918 3 serum serum NN cord-023095-4dannjjm 3918 4 IFN IFN NNP cord-023095-4dannjjm 3918 5 - - HYPH cord-023095-4dannjjm 3918 6 g g NNP cord-023095-4dannjjm 3918 7 was be VBD cord-023095-4dannjjm 3918 8 also also RB cord-023095-4dannjjm 3918 9 performed perform VBN cord-023095-4dannjjm 3918 10 using use VBG cord-023095-4dannjjm 3918 11 a a DT cord-023095-4dannjjm 3918 12 commercially commercially RB cord-023095-4dannjjm 3918 13 available available JJ cord-023095-4dannjjm 3918 14 canine canine JJ cord-023095-4dannjjm 3918 15 - - HYPH cord-023095-4dannjjm 3918 16 specific specific JJ cord-023095-4dannjjm 3918 17 ELISA ELISA NNP cord-023095-4dannjjm 3918 18 . . . cord-023095-4dannjjm 3919 1 All all DT cord-023095-4dannjjm 3919 2 samples sample NNS cord-023095-4dannjjm 3919 3 were be VBD cord-023095-4dannjjm 3919 4 positive positive JJ cord-023095-4dannjjm 3919 5 for for IN cord-023095-4dannjjm 3919 6 housekeeping housekeeping NN cord-023095-4dannjjm 3919 7 genes gene NNS cord-023095-4dannjjm 3919 8 and and CC cord-023095-4dannjjm 3919 9 all all DT cord-023095-4dannjjm 3919 10 cytokines cytokine NNS cord-023095-4dannjjm 3919 11 could could MD cord-023095-4dannjjm 3919 12 be be VB cord-023095-4dannjjm 3919 13 quantified quantify VBN cord-023095-4dannjjm 3919 14 with with IN cord-023095-4dannjjm 3919 15 the the DT cord-023095-4dannjjm 3919 16 exception exception NN cord-023095-4dannjjm 3919 17 of of IN cord-023095-4dannjjm 3919 18 eotaxin-2 eotaxin-2 NNPS cord-023095-4dannjjm 3919 19 and and CC cord-023095-4dannjjm 3919 20 -3 -3 NNP cord-023095-4dannjjm 3919 21 . . . cord-023095-4dannjjm 3920 1 Results result NNS cord-023095-4dannjjm 3920 2 were be VBD cord-023095-4dannjjm 3920 3 normalised normalise VBN cord-023095-4dannjjm 3920 4 using use VBG cord-023095-4dannjjm 3920 5 three three CD cord-023095-4dannjjm 3920 6 stably stably RB cord-023095-4dannjjm 3920 7 expressed express VBD cord-023095-4dannjjm 3920 8 housekeeper housekeeper NN cord-023095-4dannjjm 3920 9 genes gene NNS cord-023095-4dannjjm 3920 10 ( ( -LRB- cord-023095-4dannjjm 3920 11 RPL13A RPL13A NNS cord-023095-4dannjjm 3920 12 , , , cord-023095-4dannjjm 3920 13 SDHA SDHA NNP cord-023095-4dannjjm 3920 14 and and CC cord-023095-4dannjjm 3920 15 YWAZ YWAZ NNP cord-023095-4dannjjm 3920 16 ) ) -RRB- cord-023095-4dannjjm 3920 17 and and CC cord-023095-4dannjjm 3920 18 a a DT cord-023095-4dannjjm 3920 19 relative relative JJ cord-023095-4dannjjm 3920 20 copy copy NN cord-023095-4dannjjm 3920 21 number number NN cord-023095-4dannjjm 3920 22 was be VBD cord-023095-4dannjjm 3920 23 calculated calculate VBN cord-023095-4dannjjm 3920 24 for for IN cord-023095-4dannjjm 3920 25 each each DT cord-023095-4dannjjm 3920 26 sample sample NN cord-023095-4dannjjm 3920 27 with with IN cord-023095-4dannjjm 3920 28 the the DT cord-023095-4dannjjm 3920 29 sample sample NN cord-023095-4dannjjm 3920 30 with with IN cord-023095-4dannjjm 3920 31 the the DT cord-023095-4dannjjm 3920 32 fewest few JJS cord-023095-4dannjjm 3920 33 copies copy NNS cord-023095-4dannjjm 3920 34 given give VBN cord-023095-4dannjjm 3920 35 a a DT cord-023095-4dannjjm 3920 36 value value NN cord-023095-4dannjjm 3920 37 of of IN cord-023095-4dannjjm 3920 38 1 1 CD cord-023095-4dannjjm 3920 39 . . . cord-023095-4dannjjm 3921 1 No no DT cord-023095-4dannjjm 3921 2 significant significant JJ cord-023095-4dannjjm 3921 3 differences difference NNS cord-023095-4dannjjm 3921 4 were be VBD cord-023095-4dannjjm 3921 5 found find VBN cord-023095-4dannjjm 3921 6 between between IN cord-023095-4dannjjm 3921 7 groups group NNS cord-023095-4dannjjm 3921 8 but but CC cord-023095-4dannjjm 3921 9 there there EX cord-023095-4dannjjm 3921 10 was be VBD cord-023095-4dannjjm 3921 11 a a DT cord-023095-4dannjjm 3921 12 tendency tendency NN cord-023095-4dannjjm 3921 13 for for IN cord-023095-4dannjjm 3921 14 IFN IFN NNP cord-023095-4dannjjm 3921 15 - - HYPH cord-023095-4dannjjm 3921 16 g g NNP cord-023095-4dannjjm 3921 17 mRNA mrna NN cord-023095-4dannjjm 3921 18 expression expression NN cord-023095-4dannjjm 3921 19 to to TO cord-023095-4dannjjm 3921 20 be be VB cord-023095-4dannjjm 3921 21 lower low JJR cord-023095-4dannjjm 3921 22 in in IN cord-023095-4dannjjm 3921 23 the the DT cord-023095-4dannjjm 3921 24 Rottweilers Rottweilers NNPS cord-023095-4dannjjm 3921 25 with with IN cord-023095-4dannjjm 3921 26 moderate moderate JJ cord-023095-4dannjjm 3921 27 to to IN cord-023095-4dannjjm 3921 28 severe severe JJ cord-023095-4dannjjm 3921 29 eosinophilia eosinophilia NN cord-023095-4dannjjm 3921 30 versus versus IN cord-023095-4dannjjm 3921 31 control control NN cord-023095-4dannjjm 3921 32 dogs dog NNS cord-023095-4dannjjm 3921 33 ( ( -LRB- cord-023095-4dannjjm 3921 34 p p NN cord-023095-4dannjjm 3921 35 5 5 CD cord-023095-4dannjjm 3921 36 0.062 0.062 CD cord-023095-4dannjjm 3921 37 ) ) -RRB- cord-023095-4dannjjm 3921 38 . . . cord-023095-4dannjjm 3922 1 This this DT cord-023095-4dannjjm 3922 2 trend trend NN cord-023095-4dannjjm 3922 3 was be VBD cord-023095-4dannjjm 3922 4 not not RB cord-023095-4dannjjm 3922 5 seen see VBN cord-023095-4dannjjm 3922 6 in in IN cord-023095-4dannjjm 3922 7 the the DT cord-023095-4dannjjm 3922 8 concentration concentration NN cord-023095-4dannjjm 3922 9 of of IN cord-023095-4dannjjm 3922 10 serum serum NN cord-023095-4dannjjm 3922 11 IFN IFN NNP cord-023095-4dannjjm 3922 12 - - HYPH cord-023095-4dannjjm 3922 13 g g NNP cord-023095-4dannjjm 3922 14 quantified quantify VBN cord-023095-4dannjjm 3922 15 by by IN cord-023095-4dannjjm 3922 16 ELISA ELISA NNP cord-023095-4dannjjm 3922 17 as as IN cord-023095-4dannjjm 3922 18 there there EX cord-023095-4dannjjm 3922 19 were be VBD cord-023095-4dannjjm 3922 20 no no DT cord-023095-4dannjjm 3922 21 significant significant JJ cord-023095-4dannjjm 3922 22 differences difference NNS cord-023095-4dannjjm 3922 23 between between IN cord-023095-4dannjjm 3922 24 normal normal JJ cord-023095-4dannjjm 3922 25 and and CC cord-023095-4dannjjm 3922 26 diseased diseased JJ cord-023095-4dannjjm 3922 27 animals animal NNS cord-023095-4dannjjm 3922 28 . . . cord-023095-4dannjjm 3923 1 In in IN cord-023095-4dannjjm 3923 2 conclusion conclusion NN cord-023095-4dannjjm 3923 3 , , , cord-023095-4dannjjm 3923 4 there there EX cord-023095-4dannjjm 3923 5 were be VBD cord-023095-4dannjjm 3923 6 no no DT cord-023095-4dannjjm 3923 7 significant significant JJ cord-023095-4dannjjm 3923 8 differences difference NNS cord-023095-4dannjjm 3923 9 in in IN cord-023095-4dannjjm 3924 1 cytokine cytokine NN cord-023095-4dannjjm 3924 2 mRNA mRNA NNP cord-023095-4dannjjm 3924 3 profiles profile NNS cord-023095-4dannjjm 3924 4 between between IN cord-023095-4dannjjm 3924 5 normal normal JJ cord-023095-4dannjjm 3924 6 dogs dog NNS cord-023095-4dannjjm 3924 7 and and CC cord-023095-4dannjjm 3924 8 Rottweilers rottweiler NNS cord-023095-4dannjjm 3924 9 with with IN cord-023095-4dannjjm 3924 10 varying vary VBG cord-023095-4dannjjm 3924 11 degrees degree NNS cord-023095-4dannjjm 3924 12 of of IN cord-023095-4dannjjm 3924 13 eosinophilia eosinophilia NN cord-023095-4dannjjm 3924 14 . . . cord-023095-4dannjjm 3925 1 Additional additional JJ cord-023095-4dannjjm 3925 2 studies study NNS cord-023095-4dannjjm 3925 3 including include VBG cord-023095-4dannjjm 3925 4 larger large JJR cord-023095-4dannjjm 3925 5 numbers number NNS cord-023095-4dannjjm 3925 6 of of IN cord-023095-4dannjjm 3925 7 affected affect VBN cord-023095-4dannjjm 3925 8 dogs dog NNS cord-023095-4dannjjm 3925 9 are be VBP cord-023095-4dannjjm 3925 10 warranted warrant VBN cord-023095-4dannjjm 3925 11 before before IN cord-023095-4dannjjm 3925 12 any any DT cord-023095-4dannjjm 3925 13 accurate accurate JJ cord-023095-4dannjjm 3925 14 conclusions conclusion NNS cord-023095-4dannjjm 3925 15 can can MD cord-023095-4dannjjm 3925 16 be be VB cord-023095-4dannjjm 3925 17 made make VBN cord-023095-4dannjjm 3925 18 . . . cord-023095-4dannjjm 3926 1 The the DT cord-023095-4dannjjm 3926 2 presence presence NN cord-023095-4dannjjm 3926 3 of of IN cord-023095-4dannjjm 3926 4 large large JJ cord-023095-4dannjjm 3926 5 amount amount NN cord-023095-4dannjjm 3926 6 of of IN cord-023095-4dannjjm 3926 7 antibody antibody NN cord-023095-4dannjjm 3926 8 on on IN cord-023095-4dannjjm 3926 9 erythrocyte erythrocyte NN cord-023095-4dannjjm 3926 10 membrane membrane NN cord-023095-4dannjjm 3926 11 can can MD cord-023095-4dannjjm 3926 12 accelerate accelerate VB cord-023095-4dannjjm 3926 13 red red JJ cord-023095-4dannjjm 3926 14 blood blood NN cord-023095-4dannjjm 3926 15 cell cell NN cord-023095-4dannjjm 3926 16 ( ( -LRB- cord-023095-4dannjjm 3926 17 RBC RBC NNP cord-023095-4dannjjm 3926 18 ) ) -RRB- cord-023095-4dannjjm 3926 19 removal removal NN cord-023095-4dannjjm 3926 20 process process NN cord-023095-4dannjjm 3926 21 by by IN cord-023095-4dannjjm 3926 22 the the DT cord-023095-4dannjjm 3926 23 mononuclear mononuclear JJ cord-023095-4dannjjm 3926 24 phagocyte phagocyte NNP cord-023095-4dannjjm 3926 25 system system NN cord-023095-4dannjjm 3926 26 . . . cord-023095-4dannjjm 3927 1 An an DT cord-023095-4dannjjm 3927 2 antigenic antigenic JJ cord-023095-4dannjjm 3927 3 stimulus stimulus NN cord-023095-4dannjjm 3927 4 such such JJ cord-023095-4dannjjm 3927 5 as as IN cord-023095-4dannjjm 3927 6 the the DT cord-023095-4dannjjm 3927 7 one one CD cord-023095-4dannjjm 3927 8 promoted promote VBN cord-023095-4dannjjm 3927 9 by by IN cord-023095-4dannjjm 3927 10 vaccines vaccine NNS cord-023095-4dannjjm 3927 11 , , , cord-023095-4dannjjm 3927 12 for for IN cord-023095-4dannjjm 3927 13 example example NN cord-023095-4dannjjm 3927 14 , , , cord-023095-4dannjjm 3927 15 can can MD cord-023095-4dannjjm 3927 16 induce induce VB cord-023095-4dannjjm 3927 17 hypersensitivity hypersensitivity NN cord-023095-4dannjjm 3927 18 reactions reaction NNS cord-023095-4dannjjm 3927 19 and and CC cord-023095-4dannjjm 3927 20 may may MD cord-023095-4dannjjm 3927 21 accelerate accelerate VB cord-023095-4dannjjm 3927 22 RBC RBC NNP cord-023095-4dannjjm 3927 23 destruction destruction NN cord-023095-4dannjjm 3927 24 . . . cord-023095-4dannjjm 3928 1 The the DT cord-023095-4dannjjm 3928 2 study study NN cord-023095-4dannjjm 3928 3 objective objective NN cord-023095-4dannjjm 3928 4 was be VBD cord-023095-4dannjjm 3928 5 to to TO cord-023095-4dannjjm 3928 6 evaluate evaluate VB cord-023095-4dannjjm 3928 7 the the DT cord-023095-4dannjjm 3928 8 erythrocytic erythrocytic JJ cord-023095-4dannjjm 3928 9 membrane membrane NN cord-023095-4dannjjm 3928 10 potential potential NN cord-023095-4dannjjm 3928 11 in in IN cord-023095-4dannjjm 3928 12 inducing induce VBG cord-023095-4dannjjm 3928 13 lymphocyte lymphocyte NN cord-023095-4dannjjm 3928 14 proliferative proliferative JJ cord-023095-4dannjjm 3928 15 response response NN cord-023095-4dannjjm 3928 16 of of IN cord-023095-4dannjjm 3928 17 recently recently RB cord-023095-4dannjjm 3928 18 immunized immunize VBN cord-023095-4dannjjm 3928 19 dogs dog NNS cord-023095-4dannjjm 3928 20 . . . cord-023095-4dannjjm 3929 1 Healthy healthy JJ cord-023095-4dannjjm 3929 2 adult adult NN cord-023095-4dannjjm 3929 3 dogs dog NNS cord-023095-4dannjjm 3929 4 ( ( -LRB- cord-023095-4dannjjm 3929 5 n n NN cord-023095-4dannjjm 3929 6 5 5 CD cord-023095-4dannjjm 3929 7 17 17 CD cord-023095-4dannjjm 3929 8 ) ) -RRB- cord-023095-4dannjjm 3929 9 were be VBD cord-023095-4dannjjm 3929 10 immunized immunize VBN cord-023095-4dannjjm 3929 11 with with IN cord-023095-4dannjjm 3929 12 multiple multiple JJ cord-023095-4dannjjm 3929 13 antigens antigen NNS cord-023095-4dannjjm 3929 14 ( ( -LRB- cord-023095-4dannjjm 3929 15 commercial commercial JJ cord-023095-4dannjjm 3929 16 vaccine vaccine NN cord-023095-4dannjjm 3929 17 with with IN cord-023095-4dannjjm 3929 18 eight eight CD cord-023095-4dannjjm 3929 19 antigens antigen NNS cord-023095-4dannjjm 3929 20 : : : cord-023095-4dannjjm 3929 21 distemper distemper NN cord-023095-4dannjjm 3929 22 virus virus NN cord-023095-4dannjjm 3929 23 , , , cord-023095-4dannjjm 3929 24 parvovirus parvovirus NN cord-023095-4dannjjm 3929 25 , , , cord-023095-4dannjjm 3929 26 coronavirus coronavirus NN cord-023095-4dannjjm 3929 27 , , , cord-023095-4dannjjm 3929 28 parainfluenza parainfluenza NNP cord-023095-4dannjjm 3929 29 virus virus NN cord-023095-4dannjjm 3929 30 , , , cord-023095-4dannjjm 3929 31 adenovirus adenovirus NN cord-023095-4dannjjm 3929 32 , , , cord-023095-4dannjjm 3929 33 infectious infectious JJ cord-023095-4dannjjm 3929 34 hepatitis hepatitis NN cord-023095-4dannjjm 3929 35 virus virus NN cord-023095-4dannjjm 3929 36 and and CC cord-023095-4dannjjm 3929 37 leptospire leptospire NN cord-023095-4dannjjm 3929 38 ; ; : cord-023095-4dannjjm 3929 39 and and CC cord-023095-4dannjjm 3929 40 anti anti JJ cord-023095-4dannjjm 3929 41 - - JJ cord-023095-4dannjjm 3929 42 rabies rabies JJ cord-023095-4dannjjm 3929 43 ) ) -RRB- cord-023095-4dannjjm 3929 44 . . . cord-023095-4dannjjm 3930 1 Blood blood NN cord-023095-4dannjjm 3930 2 samples sample NNS cord-023095-4dannjjm 3930 3 from from IN cord-023095-4dannjjm 3930 4 each each DT cord-023095-4dannjjm 3930 5 animal animal NN cord-023095-4dannjjm 3930 6 were be VBD cord-023095-4dannjjm 3930 7 collected collect VBN cord-023095-4dannjjm 3930 8 into into IN cord-023095-4dannjjm 3930 9 EDTA EDTA NNP cord-023095-4dannjjm 3930 10 tubes tube NNS cord-023095-4dannjjm 3930 11 in in IN cord-023095-4dannjjm 3930 12 two two CD cord-023095-4dannjjm 3930 13 moments moment NNS cord-023095-4dannjjm 3930 14 : : : cord-023095-4dannjjm 3930 15 PRE pre VB cord-023095-4dannjjm 3930 16 ( ( -LRB- cord-023095-4dannjjm 3930 17 immediately immediately RB cord-023095-4dannjjm 3930 18 before before IN cord-023095-4dannjjm 3930 19 vaccination vaccination NN cord-023095-4dannjjm 3930 20 ) ) -RRB- cord-023095-4dannjjm 3930 21 and and CC cord-023095-4dannjjm 3930 22 POS POS NNP cord-023095-4dannjjm 3930 23 ( ( -LRB- cord-023095-4dannjjm 3930 24 28 28 CD cord-023095-4dannjjm 3930 25 to to TO cord-023095-4dannjjm 3930 26 35 35 CD cord-023095-4dannjjm 3930 27 days day NNS cord-023095-4dannjjm 3930 28 after after IN cord-023095-4dannjjm 3930 29 vaccination vaccination NN cord-023095-4dannjjm 3930 30 ) ) -RRB- cord-023095-4dannjjm 3930 31 . . . cord-023095-4dannjjm 3931 1 Mononuclear Mononuclear NNP cord-023095-4dannjjm 3931 2 cells cell NNS cord-023095-4dannjjm 3931 3 were be VBD cord-023095-4dannjjm 3931 4 separated separate VBN cord-023095-4dannjjm 3931 5 by by IN cord-023095-4dannjjm 3931 6 gradient gradient NN cord-023095-4dannjjm 3931 7 , , , cord-023095-4dannjjm 3931 8 marked mark VBN cord-023095-4dannjjm 3931 9 with with IN cord-023095-4dannjjm 3931 10 CFSE CFSE NNP cord-023095-4dannjjm 3931 11 - - HYPH cord-023095-4dannjjm 3931 12 FITC FITC NNP cord-023095-4dannjjm 3931 13 and and CC cord-023095-4dannjjm 3931 14 cultured cultured JJ cord-023095-4dannjjm 3931 15 . . . cord-023095-4dannjjm 3932 1 The the DT cord-023095-4dannjjm 3932 2 stimuli stimulus NNS cord-023095-4dannjjm 3932 3 for for IN cord-023095-4dannjjm 3932 4 lymphocyte lymphocyte NN cord-023095-4dannjjm 3932 5 proliferation proliferation NN cord-023095-4dannjjm 3932 6 used use VBN cord-023095-4dannjjm 3932 7 were be VBD cord-023095-4dannjjm 3932 8 autologous autologous JJ cord-023095-4dannjjm 3932 9 erythrocytic erythrocytic JJ cord-023095-4dannjjm 3932 10 membrane membrane NN cord-023095-4dannjjm 3932 11 ( ( -LRB- cord-023095-4dannjjm 3932 12 AEM AEM NNP cord-023095-4dannjjm 3932 13 ) ) -RRB- cord-023095-4dannjjm 3932 14 and and CC cord-023095-4dannjjm 3932 15 Concanavalin Concanavalin NNP cord-023095-4dannjjm 3932 16 A A NNP cord-023095-4dannjjm 3932 17 ( ( -LRB- cord-023095-4dannjjm 3932 18 ConA ConA NNP cord-023095-4dannjjm 3932 19 ) ) -RRB- cord-023095-4dannjjm 3932 20 . . . cord-023095-4dannjjm 3933 1 AEM AEM NNP cord-023095-4dannjjm 3933 2 was be VBD cord-023095-4dannjjm 3933 3 obtained obtain VBN cord-023095-4dannjjm 3933 4 by by IN cord-023095-4dannjjm 3933 5 hypotonic hypotonic JJ cord-023095-4dannjjm 3933 6 lysis lysis NN cord-023095-4dannjjm 3933 7 and and CC cord-023095-4dannjjm 3933 8 tested test VBN cord-023095-4dannjjm 3933 9 in in IN cord-023095-4dannjjm 3933 10 two two CD cord-023095-4dannjjm 3933 11 concentrations concentration NNS cord-023095-4dannjjm 3933 12 ( ( -LRB- cord-023095-4dannjjm 3933 13 M1 M1 NNP cord-023095-4dannjjm 3933 14 : : : cord-023095-4dannjjm 3933 15 0.1ug/100uL 0.1ug/100ul CD cord-023095-4dannjjm 3933 16 ; ; : cord-023095-4dannjjm 3933 17 M2 m2 NN cord-023095-4dannjjm 3933 18 : : : cord-023095-4dannjjm 3933 19 0.2 0.2 CD cord-023095-4dannjjm 3933 20 ug/100uL ug/100uL NNP cord-023095-4dannjjm 3933 21 ) ) -RRB- cord-023095-4dannjjm 3933 22 . . . cord-023095-4dannjjm 3934 1 The the DT cord-023095-4dannjjm 3934 2 proliferation proliferation NN cord-023095-4dannjjm 3934 3 assay assay NN cord-023095-4dannjjm 3934 4 was be VBD cord-023095-4dannjjm 3934 5 evaluated evaluate VBN cord-023095-4dannjjm 3934 6 by by IN cord-023095-4dannjjm 3934 7 flow flow NN cord-023095-4dannjjm 3934 8 cytometry cytometry NN cord-023095-4dannjjm 3934 9 and and CC cord-023095-4dannjjm 3934 10 analyzed analyze VBN cord-023095-4dannjjm 3934 11 with with IN cord-023095-4dannjjm 3934 12 specific specific JJ cord-023095-4dannjjm 3934 13 software software NN cord-023095-4dannjjm 3934 14 . . . cord-023095-4dannjjm 3935 1 The the DT cord-023095-4dannjjm 3935 2 proliferation proliferation NN cord-023095-4dannjjm 3935 3 index index NN cord-023095-4dannjjm 3935 4 ( ( -LRB- cord-023095-4dannjjm 3935 5 PI PI NNP cord-023095-4dannjjm 3935 6 ) ) -RRB- cord-023095-4dannjjm 3935 7 was be VBD cord-023095-4dannjjm 3935 8 calculated calculate VBN cord-023095-4dannjjm 3935 9 dividing divide VBG cord-023095-4dannjjm 3935 10 the the DT cord-023095-4dannjjm 3935 11 fluorescence fluorescence NN cord-023095-4dannjjm 3935 12 intensity intensity NN cord-023095-4dannjjm 3935 13 of of IN cord-023095-4dannjjm 3935 14 the the DT cord-023095-4dannjjm 3935 15 basal basal NN cord-023095-4dannjjm 3935 16 sample sample NN cord-023095-4dannjjm 3935 17 by by IN cord-023095-4dannjjm 3935 18 the the DT cord-023095-4dannjjm 3935 19 stimulated stimulate VBN cord-023095-4dannjjm 3935 20 one one CD cord-023095-4dannjjm 3935 21 . . . cord-023095-4dannjjm 3936 1 Statistical statistical JJ cord-023095-4dannjjm 3936 2 analysis analysis NN cord-023095-4dannjjm 3936 3 was be VBD cord-023095-4dannjjm 3936 4 performed perform VBN cord-023095-4dannjjm 3936 5 using use VBG cord-023095-4dannjjm 3936 6 paired pair VBN cord-023095-4dannjjm 3936 7 t t NN cord-023095-4dannjjm 3936 8 - - HYPH cord-023095-4dannjjm 3936 9 test test NN cord-023095-4dannjjm 3936 10 for for IN cord-023095-4dannjjm 3936 11 parametric parametric JJ cord-023095-4dannjjm 3936 12 samples sample NNS cord-023095-4dannjjm 3936 13 and and CC cord-023095-4dannjjm 3936 14 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 3936 15 test test NN cord-023095-4dannjjm 3936 16 for for IN cord-023095-4dannjjm 3936 17 non non JJ cord-023095-4dannjjm 3936 18 - - JJ cord-023095-4dannjjm 3936 19 parametric parametric JJ cord-023095-4dannjjm 3936 20 samples sample NNS cord-023095-4dannjjm 3936 21 ( ( -LRB- cord-023095-4dannjjm 3936 22 a a DT cord-023095-4dannjjm 3936 23 5 5 CD cord-023095-4dannjjm 3936 24 0.05 0.05 CD cord-023095-4dannjjm 3936 25 ) ) -RRB- cord-023095-4dannjjm 3936 26 . . . cord-023095-4dannjjm 3937 1 The the DT cord-023095-4dannjjm 3937 2 For for IN cord-023095-4dannjjm 3937 3 the the DT cord-023095-4dannjjm 3937 4 tested test VBN cord-023095-4dannjjm 3937 5 concentrations concentration NNS cord-023095-4dannjjm 3937 6 , , , cord-023095-4dannjjm 3937 7 autologous autologous JJ cord-023095-4dannjjm 3937 8 erythrocytic erythrocytic JJ cord-023095-4dannjjm 3937 9 membrane membrane NN cord-023095-4dannjjm 3937 10 does do VBZ cord-023095-4dannjjm 3937 11 not not RB cord-023095-4dannjjm 3937 12 constitute constitute VB cord-023095-4dannjjm 3937 13 a a DT cord-023095-4dannjjm 3937 14 stimulus stimulus NN cord-023095-4dannjjm 3937 15 for for IN cord-023095-4dannjjm 3937 16 lymphocyte lymphocyte NN cord-023095-4dannjjm 3937 17 proliferation proliferation NN cord-023095-4dannjjm 3937 18 in in IN cord-023095-4dannjjm 3937 19 vitro vitro FW cord-023095-4dannjjm 3937 20 , , , cord-023095-4dannjjm 3937 21 either either CC cord-023095-4dannjjm 3937 22 before before IN cord-023095-4dannjjm 3937 23 or or CC cord-023095-4dannjjm 3937 24 after after IN cord-023095-4dannjjm 3937 25 vaccination vaccination NN cord-023095-4dannjjm 3937 26 procedure procedure NN cord-023095-4dannjjm 3937 27 . . . cord-023095-4dannjjm 3938 1 Additionally additionally RB cord-023095-4dannjjm 3938 2 , , , cord-023095-4dannjjm 3938 3 there there EX cord-023095-4dannjjm 3938 4 was be VBD cord-023095-4dannjjm 3938 5 no no DT cord-023095-4dannjjm 3938 6 evidence evidence NN cord-023095-4dannjjm 3938 7 of of IN cord-023095-4dannjjm 3938 8 self self NN cord-023095-4dannjjm 3938 9 - - HYPH cord-023095-4dannjjm 3938 10 reagent reagent NN cord-023095-4dannjjm 3938 11 lymphocytes lymphocyte NNS cord-023095-4dannjjm 3938 12 to to IN cord-023095-4dannjjm 3938 13 erythrocyte erythrocyte NN cord-023095-4dannjjm 3938 14 membrane membrane NN cord-023095-4dannjjm 3938 15 after after IN cord-023095-4dannjjm 3938 16 vaccination vaccination NN cord-023095-4dannjjm 3938 17 . . . cord-023095-4dannjjm 3939 1 E. E. NNP cord-023095-4dannjjm 3939 2 coli coli NNS cord-023095-4dannjjm 3939 3 is be VBZ cord-023095-4dannjjm 3939 4 a a DT cord-023095-4dannjjm 3939 5 common common JJ cord-023095-4dannjjm 3939 6 cause cause NN cord-023095-4dannjjm 3939 7 of of IN cord-023095-4dannjjm 3939 8 canine canine JJ cord-023095-4dannjjm 3939 9 urinary urinary JJ cord-023095-4dannjjm 3939 10 tract tract NN cord-023095-4dannjjm 3939 11 infection infection NN cord-023095-4dannjjm 3939 12 . . . cord-023095-4dannjjm 3940 1 Current current JJ cord-023095-4dannjjm 3940 2 treatment treatment NN cord-023095-4dannjjm 3940 3 emphasizes emphasize VBZ cord-023095-4dannjjm 3940 4 eradication eradication NN cord-023095-4dannjjm 3940 5 of of IN cord-023095-4dannjjm 3940 6 established establish VBN cord-023095-4dannjjm 3940 7 infection infection NN cord-023095-4dannjjm 3940 8 rather rather RB cord-023095-4dannjjm 3940 9 than than IN cord-023095-4dannjjm 3940 10 infection infection NN cord-023095-4dannjjm 3940 11 prevention prevention NN cord-023095-4dannjjm 3940 12 but but CC cord-023095-4dannjjm 3940 13 increased increase VBD cord-023095-4dannjjm 3940 14 antibiotic antibiotic JJ cord-023095-4dannjjm 3940 15 resistance resistance NN cord-023095-4dannjjm 3940 16 necessitates necessitate VBZ cord-023095-4dannjjm 3940 17 strategies strategy NNS cord-023095-4dannjjm 3940 18 to to TO cord-023095-4dannjjm 3940 19 prevent prevent VB cord-023095-4dannjjm 3940 20 infection infection NN cord-023095-4dannjjm 3940 21 . . . cord-023095-4dannjjm 3941 1 Proanthocyanidins Proanthocyanidins NNP cord-023095-4dannjjm 3941 2 found find VBD cord-023095-4dannjjm 3941 3 in in IN cord-023095-4dannjjm 3941 4 cranberry cranberry NN cord-023095-4dannjjm 3941 5 juice juice NN cord-023095-4dannjjm 3941 6 inhibit inhibit NN cord-023095-4dannjjm 3941 7 E. E. NNP cord-023095-4dannjjm 3941 8 coli coli NN cord-023095-4dannjjm 3941 9 attachment attachment NN cord-023095-4dannjjm 3941 10 to to IN cord-023095-4dannjjm 3941 11 human human JJ cord-023095-4dannjjm 3941 12 uroepithelial uroepithelial JJ cord-023095-4dannjjm 3941 13 cells cell NNS cord-023095-4dannjjm 3941 14 , , , cord-023095-4dannjjm 3941 15 impairing impair VBG cord-023095-4dannjjm 3941 16 bacterial bacterial JJ cord-023095-4dannjjm 3941 17 adherence adherence NN cord-023095-4dannjjm 3941 18 and and CC cord-023095-4dannjjm 3941 19 colonization colonization NN cord-023095-4dannjjm 3941 20 . . . cord-023095-4dannjjm 3942 1 We -PRON- PRP cord-023095-4dannjjm 3942 2 hypothesized hypothesize VBD cord-023095-4dannjjm 3942 3 that that IN cord-023095-4dannjjm 3942 4 purified purify VBN cord-023095-4dannjjm 3942 5 cranberry cranberry NN cord-023095-4dannjjm 3942 6 extract extract NN cord-023095-4dannjjm 3942 7 ( ( -LRB- cord-023095-4dannjjm 3942 8 CE CE NNP cord-023095-4dannjjm 3942 9 ) ) -RRB- cord-023095-4dannjjm 3942 10 inhibits inhibit VBZ cord-023095-4dannjjm 3942 11 bacterial bacterial JJ cord-023095-4dannjjm 3942 12 adhesion adhesion NN cord-023095-4dannjjm 3942 13 to to IN cord-023095-4dannjjm 3942 14 canine canine JJ cord-023095-4dannjjm 3942 15 uroepithelial uroepithelial JJ cord-023095-4dannjjm 3942 16 cells cell NNS cord-023095-4dannjjm 3942 17 . . . cord-023095-4dannjjm 3943 1 Five five CD cord-023095-4dannjjm 3943 2 healthy healthy JJ cord-023095-4dannjjm 3943 3 female female JJ cord-023095-4dannjjm 3943 4 dogs dog NNS cord-023095-4dannjjm 3943 5 received receive VBD cord-023095-4dannjjm 3943 6 an an DT cord-023095-4dannjjm 3943 7 oral oral JJ cord-023095-4dannjjm 3943 8 CE ce NN cord-023095-4dannjjm 3943 9 supplement supplement NN cord-023095-4dannjjm 3943 10 ( ( -LRB- cord-023095-4dannjjm 3943 11 Vetoquinol Vetoquinol NNP cord-023095-4dannjjm 3943 12 ; ; : cord-023095-4dannjjm 3943 13 100 100 CD cord-023095-4dannjjm 3943 14 mg mg NNP cord-023095-4dannjjm 3943 15 CE CE NNP cord-023095-4dannjjm 3943 16 / / SYM cord-023095-4dannjjm 3943 17 tablet tablet NN cord-023095-4dannjjm 3943 18 ) ) -RRB- cord-023095-4dannjjm 3943 19 according accord VBG cord-023095-4dannjjm 3943 20 to to IN cord-023095-4dannjjm 3943 21 body body NN cord-023095-4dannjjm 3943 22 weight weight NN cord-023095-4dannjjm 3943 23 for for IN cord-023095-4dannjjm 3943 24 30 30 CD cord-023095-4dannjjm 3943 25 days day NNS cord-023095-4dannjjm 3943 26 . . . cord-023095-4dannjjm 3944 1 Voided void VBN cord-023095-4dannjjm 3944 2 urine urine NN cord-023095-4dannjjm 3944 3 collected collect VBN cord-023095-4dannjjm 3944 4 from from IN cord-023095-4dannjjm 3944 5 each each DT cord-023095-4dannjjm 3944 6 dog dog NN cord-023095-4dannjjm 3944 7 before before IN cord-023095-4dannjjm 3944 8 ( ( -LRB- cord-023095-4dannjjm 3944 9 PRE PRE NNP cord-023095-4dannjjm 3944 10 ) ) -RRB- cord-023095-4dannjjm 3944 11 and and CC cord-023095-4dannjjm 3944 12 after after IN cord-023095-4dannjjm 3944 13 ( ( -LRB- cord-023095-4dannjjm 3944 14 30-DAY 30-day CD cord-023095-4dannjjm 3944 15 ) ) -RRB- cord-023095-4dannjjm 3944 16 completion completion NN cord-023095-4dannjjm 3944 17 of of IN cord-023095-4dannjjm 3944 18 the the DT cord-023095-4dannjjm 3944 19 protocol protocol NN cord-023095-4dannjjm 3944 20 was be VBD cord-023095-4dannjjm 3944 21 membrane membrane NN cord-023095-4dannjjm 3944 22 filtered filter VBN cord-023095-4dannjjm 3944 23 ( ( -LRB- cord-023095-4dannjjm 3944 24 22 22 CD cord-023095-4dannjjm 3944 25 mm mm NN cord-023095-4dannjjm 3944 26 ) ) -RRB- cord-023095-4dannjjm 3944 27 and and CC cord-023095-4dannjjm 3944 28 stored store VBN cord-023095-4dannjjm 3944 29 frozen frozen JJ cord-023095-4dannjjm 3944 30 ( ( -LRB- cord-023095-4dannjjm 3944 31 -20C -20C NNP cord-023095-4dannjjm 3944 32 ) ) -RRB- cord-023095-4dannjjm 3944 33 . . . cord-023095-4dannjjm 3945 1 Bacterial bacterial JJ cord-023095-4dannjjm 3945 2 adhesion adhesion NN cord-023095-4dannjjm 3945 3 was be VBD cord-023095-4dannjjm 3945 4 determined determine VBN cord-023095-4dannjjm 3945 5 using use VBG cord-023095-4dannjjm 3945 6 an an DT cord-023095-4dannjjm 3945 7 in in FW cord-023095-4dannjjm 3945 8 vitro vitro FW cord-023095-4dannjjm 3945 9 assay assay NN cord-023095-4dannjjm 3945 10 . . . cord-023095-4dannjjm 3946 1 Briefly briefly RB cord-023095-4dannjjm 3946 2 , , , cord-023095-4dannjjm 3946 3 urine urine NN cord-023095-4dannjjm 3946 4 samples sample NNS cord-023095-4dannjjm 3946 5 were be VBD cord-023095-4dannjjm 3946 6 incubated incubate VBN cord-023095-4dannjjm 3946 7 with with IN cord-023095-4dannjjm 3946 8 an an DT cord-023095-4dannjjm 3946 9 uropathogenic uropathogenic JJ cord-023095-4dannjjm 3946 10 E. E. NNP cord-023095-4dannjjm 3946 11 coli coli NNS cord-023095-4dannjjm 3946 12 strain strain NN cord-023095-4dannjjm 3946 13 that that WDT cord-023095-4dannjjm 3946 14 had have VBD cord-023095-4dannjjm 3946 15 been be VBN cord-023095-4dannjjm 3946 16 subcultured subculture VBN cord-023095-4dannjjm 3946 17 to to TO cord-023095-4dannjjm 3946 18 promote promote VB cord-023095-4dannjjm 3946 19 fimbriae fimbriae NN cord-023095-4dannjjm 3946 20 expression expression NN cord-023095-4dannjjm 3946 21 . . . cord-023095-4dannjjm 3947 1 Urine urine NN cord-023095-4dannjjm 3947 2 samples sample NNS cord-023095-4dannjjm 3947 3 containing contain VBG cord-023095-4dannjjm 3947 4 E. E. NNP cord-023095-4dannjjm 3947 5 coli coli NNS cord-023095-4dannjjm 3947 6 were be VBD cord-023095-4dannjjm 3947 7 next next RB cord-023095-4dannjjm 3947 8 incubated incubate VBN cord-023095-4dannjjm 3947 9 in in IN cord-023095-4dannjjm 3947 10 96-well 96-well CD cord-023095-4dannjjm 3947 11 plates plate NNS cord-023095-4dannjjm 3947 12 containing contain VBG cord-023095-4dannjjm 3947 13 methanol methanol NN cord-023095-4dannjjm 3947 14 - - HYPH cord-023095-4dannjjm 3947 15 fixed fix VBN cord-023095-4dannjjm 3947 16 Madin Madin NNP cord-023095-4dannjjm 3947 17 - - HYPH cord-023095-4dannjjm 3947 18 Darby Darby NNP cord-023095-4dannjjm 3947 19 Canine Canine NNP cord-023095-4dannjjm 3947 20 Kidney kidney NN cord-023095-4dannjjm 3947 21 ( ( -LRB- cord-023095-4dannjjm 3947 22 MDCK MDCK NNP cord-023095-4dannjjm 3947 23 ) ) -RRB- cord-023095-4dannjjm 3947 24 cells cell NNS cord-023095-4dannjjm 3947 25 for for IN cord-023095-4dannjjm 3947 26 1-hr 1-hr CD cord-023095-4dannjjm 3947 27 ( ( -LRB- cord-023095-4dannjjm 3947 28 35C 35c NN cord-023095-4dannjjm 3947 29 ) ) -RRB- cord-023095-4dannjjm 3947 30 to to TO cord-023095-4dannjjm 3947 31 permit permit VB cord-023095-4dannjjm 3947 32 bacterial bacterial JJ cord-023095-4dannjjm 3947 33 attachment attachment NN cord-023095-4dannjjm 3947 34 . . . cord-023095-4dannjjm 3948 1 After after IN cord-023095-4dannjjm 3948 2 incubation incubation NN cord-023095-4dannjjm 3948 3 , , , cord-023095-4dannjjm 3948 4 plates plate NNS cord-023095-4dannjjm 3948 5 were be VBD cord-023095-4dannjjm 3948 6 washed wash VBN cord-023095-4dannjjm 3948 7 to to TO cord-023095-4dannjjm 3948 8 remove remove VB cord-023095-4dannjjm 3948 9 nonadherent nonadherent NN cord-023095-4dannjjm 3948 10 bacteria bacteria NNS cord-023095-4dannjjm 3948 11 and and CC cord-023095-4dannjjm 3948 12 fresh fresh JJ cord-023095-4dannjjm 3948 13 media medium NNS cord-023095-4dannjjm 3948 14 added add VBD cord-023095-4dannjjm 3948 15 . . . cord-023095-4dannjjm 3949 1 Plates plate NNS cord-023095-4dannjjm 3949 2 were be VBD cord-023095-4dannjjm 3949 3 incubated incubate VBN cord-023095-4dannjjm 3949 4 ( ( -LRB- cord-023095-4dannjjm 3949 5 35C 35C NNP cord-023095-4dannjjm 3949 6 ) ) -RRB- cord-023095-4dannjjm 3949 7 for for IN cord-023095-4dannjjm 3949 8 4-hr 4-hr CD cord-023095-4dannjjm 3949 9 to to TO cord-023095-4dannjjm 3949 10 grow grow VB cord-023095-4dannjjm 3949 11 attached attach VBN cord-023095-4dannjjm 3949 12 bacteria bacteria NNS cord-023095-4dannjjm 3949 13 to to IN cord-023095-4dannjjm 3949 14 detection detection NN cord-023095-4dannjjm 3949 15 level level NN cord-023095-4dannjjm 3949 16 . . . cord-023095-4dannjjm 3950 1 Bacterial bacterial JJ cord-023095-4dannjjm 3950 2 concentration concentration NN cord-023095-4dannjjm 3950 3 in in IN cord-023095-4dannjjm 3950 4 each each DT cord-023095-4dannjjm 3950 5 well well NN cord-023095-4dannjjm 3950 6 was be VBD cord-023095-4dannjjm 3950 7 determined determine VBN cord-023095-4dannjjm 3950 8 using use VBG cord-023095-4dannjjm 3950 9 a a DT cord-023095-4dannjjm 3950 10 spectrophotometer spectrophotometer NN cord-023095-4dannjjm 3950 11 ( ( -LRB- cord-023095-4dannjjm 3950 12 650 650 CD cord-023095-4dannjjm 3950 13 nm nm NN cord-023095-4dannjjm 3950 14 ) ) -RRB- cord-023095-4dannjjm 3950 15 . . . cord-023095-4dannjjm 3951 1 Results result NNS cord-023095-4dannjjm 3951 2 were be VBD cord-023095-4dannjjm 3951 3 analyzed analyze VBN cord-023095-4dannjjm 3951 4 using use VBG cord-023095-4dannjjm 3951 5 the the DT cord-023095-4dannjjm 3951 6 Chi Chi NNP cord-023095-4dannjjm 3951 7 - - HYPH cord-023095-4dannjjm 3951 8 square square JJ cord-023095-4dannjjm 3951 9 test test NN cord-023095-4dannjjm 3951 10 . . . cord-023095-4dannjjm 3952 1 CE CE NNP cord-023095-4dannjjm 3952 2 significantly significantly RB cord-023095-4dannjjm 3952 3 reduced reduce VBD cord-023095-4dannjjm 3952 4 bacterial bacterial JJ cord-023095-4dannjjm 3952 5 adhesion adhesion NN cord-023095-4dannjjm 3952 6 by by IN cord-023095-4dannjjm 3952 7 30 30 CD cord-023095-4dannjjm 3952 8 % % NN cord-023095-4dannjjm 3952 9 ( ( -LRB- cord-023095-4dannjjm 3952 10 n n NN cord-023095-4dannjjm 3952 11 5 5 CD cord-023095-4dannjjm 3952 12 5 5 CD cord-023095-4dannjjm 3952 13 ; ; : cord-023095-4dannjjm 3952 14 p p CD cord-023095-4dannjjm 3952 15 0.5 0.5 CD cord-023095-4dannjjm 3952 16 ) ) -RRB- cord-023095-4dannjjm 3952 17 in in IN cord-023095-4dannjjm 3952 18 30-DAY 30-day CD cord-023095-4dannjjm 3952 19 urine urine NN cord-023095-4dannjjm 3952 20 samples sample NNS cord-023095-4dannjjm 3952 21 compared compare VBN cord-023095-4dannjjm 3952 22 with with IN cord-023095-4dannjjm 3952 23 PRE pre JJ cord-023095-4dannjjm 3952 24 samples sample NNS cord-023095-4dannjjm 3952 25 . . . cord-023095-4dannjjm 3953 1 The the DT cord-023095-4dannjjm 3953 2 results result NNS cord-023095-4dannjjm 3953 3 show show VBP cord-023095-4dannjjm 3953 4 that that IN cord-023095-4dannjjm 3953 5 CE CE NNP cord-023095-4dannjjm 3953 6 supplementation supplementation NN cord-023095-4dannjjm 3953 7 can can MD cord-023095-4dannjjm 3953 8 reduce reduce VB cord-023095-4dannjjm 3953 9 adhesion adhesion NN cord-023095-4dannjjm 3953 10 of of IN cord-023095-4dannjjm 3953 11 uropathogenic uropathogenic JJ cord-023095-4dannjjm 3953 12 E. E. NNP cord-023095-4dannjjm 3953 13 coli coli NNS cord-023095-4dannjjm 3953 14 to to IN cord-023095-4dannjjm 3953 15 canine canine JJ cord-023095-4dannjjm 3953 16 uroepithelium uroepithelium NN cord-023095-4dannjjm 3953 17 and and CC cord-023095-4dannjjm 3953 18 suggests suggest VBZ cord-023095-4dannjjm 3953 19 one one CD cord-023095-4dannjjm 3953 20 mechanism mechanism NN cord-023095-4dannjjm 3953 21 by by IN cord-023095-4dannjjm 3953 22 which which WDT cord-023095-4dannjjm 3953 23 CE CE NNP cord-023095-4dannjjm 3953 24 might may MD cord-023095-4dannjjm 3953 25 improve improve VB cord-023095-4dannjjm 3953 26 urinary urinary JJ cord-023095-4dannjjm 3953 27 tract tract NN cord-023095-4dannjjm 3953 28 health health NN cord-023095-4dannjjm 3953 29 . . . cord-023095-4dannjjm 3954 1 The the DT cord-023095-4dannjjm 3954 2 purpose purpose NN cord-023095-4dannjjm 3954 3 of of IN cord-023095-4dannjjm 3954 4 this this DT cord-023095-4dannjjm 3954 5 study study NN cord-023095-4dannjjm 3954 6 was be VBD cord-023095-4dannjjm 3954 7 to to TO cord-023095-4dannjjm 3954 8 determine determine VB cord-023095-4dannjjm 3954 9 prevalence prevalence NN cord-023095-4dannjjm 3954 10 of of IN cord-023095-4dannjjm 3954 11 4 4 CD cord-023095-4dannjjm 3954 12 urovirulence urovirulence NN cord-023095-4dannjjm 3954 13 factors factor NNS cord-023095-4dannjjm 3954 14 ( ( -LRB- cord-023095-4dannjjm 3954 15 UVFs uvf NNS cord-023095-4dannjjm 3954 16 ) ) -RRB- cord-023095-4dannjjm 3954 17 and and CC cord-023095-4dannjjm 3954 18 antimicrobial antimicrobial JJ cord-023095-4dannjjm 3954 19 resistance resistance NN cord-023095-4dannjjm 3954 20 in in IN cord-023095-4dannjjm 3954 21 canine canine JJ cord-023095-4dannjjm 3954 22 uropathogenic uropathogenic JJ cord-023095-4dannjjm 3954 23 E. E. NNP cord-023095-4dannjjm 3954 24 coli coli NNS cord-023095-4dannjjm 3954 25 ( ( -LRB- cord-023095-4dannjjm 3954 26 UPEC UPEC NNP cord-023095-4dannjjm 3954 27 ) ) -RRB- cord-023095-4dannjjm 3954 28 and and CC cord-023095-4dannjjm 3954 29 to to TO cord-023095-4dannjjm 3954 30 evaluate evaluate VB cord-023095-4dannjjm 3954 31 associations association NNS cord-023095-4dannjjm 3954 32 between between IN cord-023095-4dannjjm 3954 33 UVFs uvf NNS cord-023095-4dannjjm 3954 34 and and CC cord-023095-4dannjjm 3954 35 antimicrobial antimicrobial JJ cord-023095-4dannjjm 3954 36 resistance resistance NN cord-023095-4dannjjm 3954 37 . . . cord-023095-4dannjjm 3955 1 Two two CD cord-023095-4dannjjm 3955 2 hundred hundred CD cord-023095-4dannjjm 3955 3 and and CC cord-023095-4dannjjm 3955 4 twenty twenty CD cord-023095-4dannjjm 3955 5 - - HYPH cord-023095-4dannjjm 3955 6 one one CD cord-023095-4dannjjm 3955 7 UPEC UPEC NNP cord-023095-4dannjjm 3955 8 isolates isolate NNS cord-023095-4dannjjm 3955 9 from from IN cord-023095-4dannjjm 3955 10 samples sample NNS cord-023095-4dannjjm 3955 11 collected collect VBN cord-023095-4dannjjm 3955 12 from from IN cord-023095-4dannjjm 3955 13 184 184 CD cord-023095-4dannjjm 3955 14 different different JJ cord-023095-4dannjjm 3955 15 canine canine JJ cord-023095-4dannjjm 3955 16 patients patient NNS cord-023095-4dannjjm 3955 17 submitted submit VBN cord-023095-4dannjjm 3955 18 to to IN cord-023095-4dannjjm 3955 19 The the DT cord-023095-4dannjjm 3955 20 University University NNP cord-023095-4dannjjm 3955 21 of of IN cord-023095-4dannjjm 3955 22 Tennessee Tennessee NNP cord-023095-4dannjjm 3955 23 Microbiology Microbiology NNP cord-023095-4dannjjm 3955 24 Laboratory Laboratory NNP cord-023095-4dannjjm 3955 25 in in IN cord-023095-4dannjjm 3955 26 2007 2007 CD cord-023095-4dannjjm 3955 27 were be VBD cord-023095-4dannjjm 3955 28 evaluated evaluate VBN cord-023095-4dannjjm 3955 29 . . . cord-023095-4dannjjm 3956 1 A a DT cord-023095-4dannjjm 3956 2 multiplex multiplex JJ cord-023095-4dannjjm 3956 3 PCR pcr NN cord-023095-4dannjjm 3956 4 assay assay NN cord-023095-4dannjjm 3956 5 was be VBD cord-023095-4dannjjm 3956 6 used use VBN cord-023095-4dannjjm 3956 7 to to TO cord-023095-4dannjjm 3956 8 detect detect VB cord-023095-4dannjjm 3956 9 cnf cnf NN cord-023095-4dannjjm 3956 10 , , , cord-023095-4dannjjm 3956 11 hlyD hlyd ADD cord-023095-4dannjjm 3956 12 , , , cord-023095-4dannjjm 3956 13 sfa sfa NNP cord-023095-4dannjjm 3956 14 / / SYM cord-023095-4dannjjm 3956 15 foc foc NNP cord-023095-4dannjjm 3956 16 , , , cord-023095-4dannjjm 3956 17 and and CC cord-023095-4dannjjm 3956 18 papGIII papGIII NNPS cord-023095-4dannjjm 3956 19 in in IN cord-023095-4dannjjm 3956 20 DNA dna NN cord-023095-4dannjjm 3956 21 lysate lysate NN cord-023095-4dannjjm 3956 22 . . . cord-023095-4dannjjm 3957 1 In in IN cord-023095-4dannjjm 3957 2 vitro vitro FW cord-023095-4dannjjm 3957 3 susceptibility susceptibility NN cord-023095-4dannjjm 3957 4 was be VBD cord-023095-4dannjjm 3957 5 evaluated evaluate VBN cord-023095-4dannjjm 3957 6 and and CC cord-023095-4dannjjm 3957 7 if if IN cord-023095-4dannjjm 3957 8 the the DT cord-023095-4dannjjm 3957 9 isolate isolate NN cord-023095-4dannjjm 3957 10 was be VBD cord-023095-4dannjjm 3957 11 resistant resistant JJ cord-023095-4dannjjm 3957 12 to to IN cord-023095-4dannjjm 3957 13 any any DT cord-023095-4dannjjm 3957 14 antimicrobial antimicrobial NN cord-023095-4dannjjm 3957 15 in in IN cord-023095-4dannjjm 3957 16 a a DT cord-023095-4dannjjm 3957 17 class class NN cord-023095-4dannjjm 3957 18 , , , cord-023095-4dannjjm 3957 19 it -PRON- PRP cord-023095-4dannjjm 3957 20 was be VBD cord-023095-4dannjjm 3957 21 considered consider VBN cord-023095-4dannjjm 3957 22 resistant resistant JJ cord-023095-4dannjjm 3957 23 to to IN cord-023095-4dannjjm 3957 24 that that DT cord-023095-4dannjjm 3957 25 class class NN cord-023095-4dannjjm 3957 26 . . . cord-023095-4dannjjm 3958 1 Of of IN cord-023095-4dannjjm 3958 2 the the DT cord-023095-4dannjjm 3958 3 221 221 CD cord-023095-4dannjjm 3958 4 samples sample NNS cord-023095-4dannjjm 3958 5 , , , cord-023095-4dannjjm 3958 6 the the DT cord-023095-4dannjjm 3958 7 number number NN cord-023095-4dannjjm 3958 8 of of IN cord-023095-4dannjjm 3958 9 UVF UVF NNP cord-023095-4dannjjm 3958 10 expressed express VBD cord-023095-4dannjjm 3958 11 per per IN cord-023095-4dannjjm 3958 12 isolate isolate NN cord-023095-4dannjjm 3958 13 was be VBD cord-023095-4dannjjm 3958 14 : : : cord-023095-4dannjjm 3958 15 0 0 CD cord-023095-4dannjjm 3958 16 5 5 CD cord-023095-4dannjjm 3958 17 127/221 127/221 CD cord-023095-4dannjjm 3958 18 ( ( -LRB- cord-023095-4dannjjm 3958 19 57 57 CD cord-023095-4dannjjm 3958 20 % % NN cord-023095-4dannjjm 3958 21 ) ) -RRB- cord-023095-4dannjjm 3958 22 , , , cord-023095-4dannjjm 3958 23 1 1 CD cord-023095-4dannjjm 3958 24 5 5 CD cord-023095-4dannjjm 3958 25 27/221 27/221 CD cord-023095-4dannjjm 3958 26 ( ( -LRB- cord-023095-4dannjjm 3958 27 12 12 CD cord-023095-4dannjjm 3958 28 % % NN cord-023095-4dannjjm 3958 29 ) ) -RRB- cord-023095-4dannjjm 3958 30 , , , cord-023095-4dannjjm 3958 31 2 2 CD cord-023095-4dannjjm 3958 32 5 5 CD cord-023095-4dannjjm 3958 33 4/221 4/221 CD cord-023095-4dannjjm 3958 34 ( ( -LRB- cord-023095-4dannjjm 3958 35 2 2 CD cord-023095-4dannjjm 3958 36 % % NN cord-023095-4dannjjm 3958 37 ) ) -RRB- cord-023095-4dannjjm 3958 38 , , , cord-023095-4dannjjm 3958 39 3 3 CD cord-023095-4dannjjm 3958 40 - - SYM cord-023095-4dannjjm 3958 41 22/221 22/221 CD cord-023095-4dannjjm 3958 42 ( ( -LRB- cord-023095-4dannjjm 3958 43 10 10 CD cord-023095-4dannjjm 3958 44 % % NN cord-023095-4dannjjm 3958 45 ) ) -RRB- cord-023095-4dannjjm 3958 46 , , , cord-023095-4dannjjm 3958 47 and and CC cord-023095-4dannjjm 3958 48 4 4 CD cord-023095-4dannjjm 3958 49 5 5 CD cord-023095-4dannjjm 3958 50 41/221 41/221 CD cord-023095-4dannjjm 3958 51 ( ( -LRB- cord-023095-4dannjjm 3958 52 19 19 CD cord-023095-4dannjjm 3958 53 % % NN cord-023095-4dannjjm 3958 54 ) ) -RRB- cord-023095-4dannjjm 3958 55 . . . cord-023095-4dannjjm 3959 1 Expression expression NN cord-023095-4dannjjm 3959 2 of of IN cord-023095-4dannjjm 3959 3 UVF UVF NNP cord-023095-4dannjjm 3959 4 was be VBD cord-023095-4dannjjm 3959 5 sfa sfa NNP cord-023095-4dannjjm 3959 6 ( ( -LRB- cord-023095-4dannjjm 3959 7 33 33 CD cord-023095-4dannjjm 3959 8 % % NN cord-023095-4dannjjm 3959 9 ) ) -RRB- cord-023095-4dannjjm 3959 10 , , , cord-023095-4dannjjm 3959 11 hly hly NNP cord-023095-4dannjjm 3959 12 ( ( -LRB- cord-023095-4dannjjm 3959 13 24 24 CD cord-023095-4dannjjm 3959 14 % % NN cord-023095-4dannjjm 3959 15 ) ) -RRB- cord-023095-4dannjjm 3959 16 , , , cord-023095-4dannjjm 3959 17 cnf cnf FW cord-023095-4dannjjm 3959 18 ( ( -LRB- cord-023095-4dannjjm 3959 19 24 24 CD cord-023095-4dannjjm 3959 20 % % NN cord-023095-4dannjjm 3959 21 ) ) -RRB- cord-023095-4dannjjm 3959 22 , , , cord-023095-4dannjjm 3959 23 and and CC cord-023095-4dannjjm 3959 24 pap pap NN cord-023095-4dannjjm 3959 25 ( ( -LRB- cord-023095-4dannjjm 3959 26 19 19 CD cord-023095-4dannjjm 3959 27 % % NN cord-023095-4dannjjm 3959 28 ) ) -RRB- cord-023095-4dannjjm 3959 29 . . . cord-023095-4dannjjm 3960 1 Presence presence NN cord-023095-4dannjjm 3960 2 of of IN cord-023095-4dannjjm 3960 3 4 4 CD cord-023095-4dannjjm 3960 4 UVFs uvf NNS cord-023095-4dannjjm 3960 5 was be VBD cord-023095-4dannjjm 3960 6 associated associate VBN cord-023095-4dannjjm 3960 7 with with IN cord-023095-4dannjjm 3960 8 less less JJR cord-023095-4dannjjm 3960 9 resistance resistance NN cord-023095-4dannjjm 3960 10 ( ( -LRB- cord-023095-4dannjjm 3960 11 p p NN cord-023095-4dannjjm 3960 12 o o NN cord-023095-4dannjjm 3960 13 0.0001 0.0001 CD cord-023095-4dannjjm 3960 14 ) ) -RRB- cord-023095-4dannjjm 3960 15 . . . cord-023095-4dannjjm 3961 1 The the DT cord-023095-4dannjjm 3961 2 combination combination NN cord-023095-4dannjjm 3961 3 of of IN cord-023095-4dannjjm 3961 4 hly hly NNP cord-023095-4dannjjm 3961 5 , , , cord-023095-4dannjjm 3961 6 cnf cnf NN cord-023095-4dannjjm 3961 7 , , , cord-023095-4dannjjm 3961 8 and and CC cord-023095-4dannjjm 3961 9 sfa sfa NNP cord-023095-4dannjjm 3961 10 was be VBD cord-023095-4dannjjm 3961 11 associated associate VBN cord-023095-4dannjjm 3961 12 with with IN cord-023095-4dannjjm 3961 13 less less JJR cord-023095-4dannjjm 3961 14 resistance resistance NN cord-023095-4dannjjm 3961 15 ( ( -LRB- cord-023095-4dannjjm 3961 16 p p NN cord-023095-4dannjjm 3961 17 o o NN cord-023095-4dannjjm 3961 18 0.0001 0.0001 CD cord-023095-4dannjjm 3961 19 ) ) -RRB- cord-023095-4dannjjm 3961 20 . . . cord-023095-4dannjjm 3962 1 When when WRB cord-023095-4dannjjm 3962 2 sfa sfa NNP cord-023095-4dannjjm 3962 3 was be VBD cord-023095-4dannjjm 3962 4 present present JJ cord-023095-4dannjjm 3962 5 alone alone RB cord-023095-4dannjjm 3962 6 , , , cord-023095-4dannjjm 3962 7 resistance resistance NN cord-023095-4dannjjm 3962 8 was be VBD cord-023095-4dannjjm 3962 9 less less JJR cord-023095-4dannjjm 3962 10 ( ( -LRB- cord-023095-4dannjjm 3962 11 p p NN cord-023095-4dannjjm 3962 12 o o NN cord-023095-4dannjjm 3962 13 0.0001 0.0001 CD cord-023095-4dannjjm 3962 14 ) ) -RRB- cord-023095-4dannjjm 3962 15 . . . cord-023095-4dannjjm 3963 1 Average average JJ cord-023095-4dannjjm 3963 2 resistance resistance NN cord-023095-4dannjjm 3963 3 to to IN cord-023095-4dannjjm 3963 4 antimicrobial antimicrobial JJ cord-023095-4dannjjm 3963 5 class class NN cord-023095-4dannjjm 3963 6 by by IN cord-023095-4dannjjm 3963 7 number number NN cord-023095-4dannjjm 3963 8 of of IN cord-023095-4dannjjm 3963 9 UVFexpressed UVFexpressed NNP cord-023095-4dannjjm 3963 10 was be VBD cord-023095-4dannjjm 3963 11 : : : cord-023095-4dannjjm 3963 12 0 0 NFP cord-023095-4dannjjm 3963 13 UVF UVF NNP cord-023095-4dannjjm 3963 14 5 5 CD cord-023095-4dannjjm 3963 15 4.1 4.1 CD cord-023095-4dannjjm 3963 16 AE AE NNP cord-023095-4dannjjm 3963 17 3.3 3.3 CD cord-023095-4dannjjm 3963 18 classes class NNS cord-023095-4dannjjm 3963 19 , , , cord-023095-4dannjjm 3963 20 1 1 CD cord-023095-4dannjjm 3963 21 UVF UVF NNP cord-023095-4dannjjm 3963 22 5 5 CD cord-023095-4dannjjm 3963 23 1.2 1.2 CD cord-023095-4dannjjm 3963 24 AE AE NNP cord-023095-4dannjjm 3963 25 1.1 1.1 CD cord-023095-4dannjjm 3963 26 classes class NNS cord-023095-4dannjjm 3963 27 , , , cord-023095-4dannjjm 3963 28 2 2 CD cord-023095-4dannjjm 3963 29 UVF UVF NNP cord-023095-4dannjjm 3963 30 5 5 CD cord-023095-4dannjjm 3963 31 0.0 0.0 CD cord-023095-4dannjjm 3963 32 AE AE NNP cord-023095-4dannjjm 3963 33 0.0 0.0 CD cord-023095-4dannjjm 3963 34 classes class NNS cord-023095-4dannjjm 3963 35 , , , cord-023095-4dannjjm 3963 36 3 3 CD cord-023095-4dannjjm 3963 37 UVF UVF NNP cord-023095-4dannjjm 3963 38 5 5 CD cord-023095-4dannjjm 3963 39 0.8 0.8 CD cord-023095-4dannjjm 3963 40 AE AE NNP cord-023095-4dannjjm 3963 41 1.6 1.6 CD cord-023095-4dannjjm 3963 42 classes class NNS cord-023095-4dannjjm 3963 43 , , , cord-023095-4dannjjm 3963 44 and and CC cord-023095-4dannjjm 3963 45 4 4 CD cord-023095-4dannjjm 3963 46 UVF UVF NNP cord-023095-4dannjjm 3963 47 5 5 CD cord-023095-4dannjjm 3963 48 0.5 0.5 CD cord-023095-4dannjjm 3963 49 AE AE NNP cord-023095-4dannjjm 3963 50 1.2 1.2 CD cord-023095-4dannjjm 3963 51 classes class NNS cord-023095-4dannjjm 3963 52 . . . cord-023095-4dannjjm 3964 1 Urovirulence Urovirulence NNP cord-023095-4dannjjm 3964 2 factors factor NNS cord-023095-4dannjjm 3964 3 were be VBD cord-023095-4dannjjm 3964 4 present present JJ cord-023095-4dannjjm 3964 5 in in IN cord-023095-4dannjjm 3964 6 a a DT cord-023095-4dannjjm 3964 7 moderate moderate JJ cord-023095-4dannjjm 3964 8 number number NN cord-023095-4dannjjm 3964 9 of of IN cord-023095-4dannjjm 3964 10 UPEC UPEC NNP cord-023095-4dannjjm 3964 11 and and CC cord-023095-4dannjjm 3964 12 correlated correlate VBN cord-023095-4dannjjm 3964 13 negatively negatively RB cord-023095-4dannjjm 3964 14 with with IN cord-023095-4dannjjm 3964 15 resistance resistance NN cord-023095-4dannjjm 3964 16 . . . cord-023095-4dannjjm 3965 1 Neither neither DT cord-023095-4dannjjm 3965 2 individual individual JJ cord-023095-4dannjjm 3965 3 nor nor CC cord-023095-4dannjjm 3965 4 combinations combination NNS cord-023095-4dannjjm 3965 5 of of IN cord-023095-4dannjjm 3965 6 UVFs uvf NNS cord-023095-4dannjjm 3965 7 were be VBD cord-023095-4dannjjm 3965 8 associated associate VBN cord-023095-4dannjjm 3965 9 with with IN cord-023095-4dannjjm 3965 10 increased increase VBN cord-023095-4dannjjm 3965 11 resistance resistance NN cord-023095-4dannjjm 3965 12 . . . cord-023095-4dannjjm 3966 1 Obesity obesity NN cord-023095-4dannjjm 3966 2 is be VBZ cord-023095-4dannjjm 3966 3 associated associate VBN cord-023095-4dannjjm 3966 4 with with IN cord-023095-4dannjjm 3966 5 several several JJ cord-023095-4dannjjm 3966 6 comorbidities comorbiditie NNS cord-023095-4dannjjm 3966 7 in in IN cord-023095-4dannjjm 3966 8 dogs dog NNS cord-023095-4dannjjm 3966 9 including include VBG cord-023095-4dannjjm 3966 10 pancreatitis pancreatitis NN cord-023095-4dannjjm 3966 11 , , , cord-023095-4dannjjm 3966 12 osteoarthritis osteoarthritis NN cord-023095-4dannjjm 3966 13 , , , cord-023095-4dannjjm 3966 14 oral oral JJ cord-023095-4dannjjm 3966 15 disease disease NN cord-023095-4dannjjm 3966 16 , , , cord-023095-4dannjjm 3966 17 neoplasia neoplasia NN cord-023095-4dannjjm 3966 18 , , , cord-023095-4dannjjm 3966 19 and and CC cord-023095-4dannjjm 3966 20 lower low JJR cord-023095-4dannjjm 3966 21 urinary urinary JJ cord-023095-4dannjjm 3966 22 tract tract NN cord-023095-4dannjjm 3966 23 disease disease NN cord-023095-4dannjjm 3966 24 . . . cord-023095-4dannjjm 3967 1 Investigator investigator NN cord-023095-4dannjjm 3967 2 observations observation NNS cord-023095-4dannjjm 3967 3 led lead VBD cord-023095-4dannjjm 3967 4 to to IN cord-023095-4dannjjm 3967 5 the the DT cord-023095-4dannjjm 3967 6 hypothesis hypothesis NN cord-023095-4dannjjm 3967 7 that that IN cord-023095-4dannjjm 3967 8 morbidly morbidly RB cord-023095-4dannjjm 3967 9 obese obese JJ cord-023095-4dannjjm 3967 10 dogs dog NNS cord-023095-4dannjjm 3967 11 are be VBP cord-023095-4dannjjm 3967 12 more more RBR cord-023095-4dannjjm 3967 13 likely likely JJ cord-023095-4dannjjm 3967 14 to to TO cord-023095-4dannjjm 3967 15 have have VB cord-023095-4dannjjm 3967 16 asymptomatic asymptomatic JJ cord-023095-4dannjjm 3967 17 bacterial bacterial JJ cord-023095-4dannjjm 3967 18 urinary urinary JJ cord-023095-4dannjjm 3967 19 tract tract NN cord-023095-4dannjjm 3967 20 infections infection NNS cord-023095-4dannjjm 3967 21 ( ( -LRB- cord-023095-4dannjjm 3967 22 ABUTI ABUTI NNP cord-023095-4dannjjm 3967 23 ) ) -RRB- cord-023095-4dannjjm 3967 24 than than IN cord-023095-4dannjjm 3967 25 overweight overweight JJ cord-023095-4dannjjm 3967 26 and and CC cord-023095-4dannjjm 3967 27 moderately moderately RB cord-023095-4dannjjm 3967 28 obese obese JJ cord-023095-4dannjjm 3967 29 dogs dog NNS cord-023095-4dannjjm 3967 30 . . . cord-023095-4dannjjm 3968 1 Therefore therefore RB cord-023095-4dannjjm 3968 2 , , , cord-023095-4dannjjm 3968 3 a a DT cord-023095-4dannjjm 3968 4 pilot pilot NN cord-023095-4dannjjm 3968 5 study study NN cord-023095-4dannjjm 3968 6 was be VBD cord-023095-4dannjjm 3968 7 conducted conduct VBN cord-023095-4dannjjm 3968 8 to to TO cord-023095-4dannjjm 3968 9 screen screen VB cord-023095-4dannjjm 3968 10 for for IN cord-023095-4dannjjm 3968 11 ABUTI ABUTI NNP cord-023095-4dannjjm 3968 12 in in IN cord-023095-4dannjjm 3968 13 obese obese JJ cord-023095-4dannjjm 3968 14 dogs dog NNS cord-023095-4dannjjm 3968 15 . . . cord-023095-4dannjjm 3969 1 Urinalysis urinalysis NN cord-023095-4dannjjm 3969 2 with with IN cord-023095-4dannjjm 3969 3 urine urine NN cord-023095-4dannjjm 3969 4 culture culture NN cord-023095-4dannjjm 3969 5 and and CC cord-023095-4dannjjm 3969 6 dual dual JJ cord-023095-4dannjjm 3969 7 energy energy NN cord-023095-4dannjjm 3969 8 x x NN cord-023095-4dannjjm 3969 9 - - NN cord-023095-4dannjjm 3969 10 ray ray NNP cord-023095-4dannjjm 3969 11 absorptiometry absorptiometry NN cord-023095-4dannjjm 3969 12 ( ( -LRB- cord-023095-4dannjjm 3969 13 DXA DXA NNP cord-023095-4dannjjm 3969 14 ) ) -RRB- cord-023095-4dannjjm 3969 15 were be VBD cord-023095-4dannjjm 3969 16 performed perform VBN cord-023095-4dannjjm 3969 17 on on IN cord-023095-4dannjjm 3969 18 fortythree fortythree JJ cord-023095-4dannjjm 3969 19 dogs dog NNS cord-023095-4dannjjm 3969 20 with with IN cord-023095-4dannjjm 3969 21 body body NN cord-023095-4dannjjm 3969 22 fat fat NN cord-023095-4dannjjm 3969 23 ( ( -LRB- cord-023095-4dannjjm 3969 24 BF bf NN cord-023095-4dannjjm 3969 25 ) ) -RRB- cord-023095-4dannjjm 3969 26 percentages percentage NNS cord-023095-4dannjjm 3969 27 ranging range VBG cord-023095-4dannjjm 3969 28 from from IN cord-023095-4dannjjm 3969 29 36 36 CD cord-023095-4dannjjm 3969 30 to to TO cord-023095-4dannjjm 3969 31 56 56 CD cord-023095-4dannjjm 3969 32 % % NN cord-023095-4dannjjm 3969 33 . . . cord-023095-4dannjjm 3970 1 Following follow VBG cord-023095-4dannjjm 3970 2 DXA DXA NNP cord-023095-4dannjjm 3970 3 , , , cord-023095-4dannjjm 3970 4 subjects subject NNS cord-023095-4dannjjm 3970 5 were be VBD cord-023095-4dannjjm 3970 6 categorized categorize VBN cord-023095-4dannjjm 3970 7 as as IN cord-023095-4dannjjm 3970 8 obese obese JJ cord-023095-4dannjjm 3970 9 ( ( -LRB- cord-023095-4dannjjm 3970 10 O)(BF o)(bf VB cord-023095-4dannjjm 3970 11 5 5 CD cord-023095-4dannjjm 3970 12 35 35 CD cord-023095-4dannjjm 3970 13 - - SYM cord-023095-4dannjjm 3970 14 44 44 CD cord-023095-4dannjjm 3970 15 % % NN cord-023095-4dannjjm 3970 16 , , , cord-023095-4dannjjm 3970 17 n n NN cord-023095-4dannjjm 3970 18 5 5 CD cord-023095-4dannjjm 3970 19 17 17 CD cord-023095-4dannjjm 3970 20 ) ) -RRB- cord-023095-4dannjjm 3970 21 and and CC cord-023095-4dannjjm 3970 22 morbidly morbidly RB cord-023095-4dannjjm 3970 23 obese obese JJ cord-023095-4dannjjm 3970 24 ( ( -LRB- cord-023095-4dannjjm 3970 25 MO)(BF MO)(BF NNS cord-023095-4dannjjm 3970 26 4 4 CD cord-023095-4dannjjm 3970 27 45 45 CD cord-023095-4dannjjm 3970 28 % % NN cord-023095-4dannjjm 3970 29 , , , cord-023095-4dannjjm 3970 30 n n NN cord-023095-4dannjjm 3970 31 5 5 CD cord-023095-4dannjjm 3970 32 26 26 CD cord-023095-4dannjjm 3970 33 ) ) -RRB- cord-023095-4dannjjm 3970 34 . . . cord-023095-4dannjjm 3971 1 No no DT cord-023095-4dannjjm 3971 2 dogs dog NNS cord-023095-4dannjjm 3971 3 had have VBD cord-023095-4dannjjm 3971 4 owner owner NN cord-023095-4dannjjm 3971 5 - - HYPH cord-023095-4dannjjm 3971 6 reported report VBN cord-023095-4dannjjm 3971 7 symptoms symptom NNS cord-023095-4dannjjm 3971 8 indicative indicative JJ cord-023095-4dannjjm 3971 9 of of IN cord-023095-4dannjjm 3971 10 UTI UTI NNP cord-023095-4dannjjm 3971 11 . . . cord-023095-4dannjjm 3972 1 The the DT cord-023095-4dannjjm 3972 2 prevalence prevalence NN cord-023095-4dannjjm 3972 3 of of IN cord-023095-4dannjjm 3972 4 ABUTI ABUTI NNP cord-023095-4dannjjm 3972 5 in in IN cord-023095-4dannjjm 3972 6 O o NN cord-023095-4dannjjm 3972 7 dogs dog NNS cord-023095-4dannjjm 3972 8 was be VBD cord-023095-4dannjjm 3972 9 6 6 CD cord-023095-4dannjjm 3972 10 % % NN cord-023095-4dannjjm 3972 11 ( ( -LRB- cord-023095-4dannjjm 3972 12 n n NN cord-023095-4dannjjm 3972 13 5 5 CD cord-023095-4dannjjm 3972 14 1 1 CD cord-023095-4dannjjm 3972 15 ) ) -RRB- cord-023095-4dannjjm 3972 16 and and CC cord-023095-4dannjjm 3972 17 31 31 CD cord-023095-4dannjjm 3972 18 % % NN cord-023095-4dannjjm 3972 19 ( ( -LRB- cord-023095-4dannjjm 3972 20 n n NN cord-023095-4dannjjm 3972 21 5 5 CD cord-023095-4dannjjm 3972 22 8) 8) NN cord-023095-4dannjjm 3972 23 in in IN cord-023095-4dannjjm 3972 24 MO MO NNP cord-023095-4dannjjm 3972 25 dogs dog NNS cord-023095-4dannjjm 3972 26 . . . cord-023095-4dannjjm 3973 1 The the DT cord-023095-4dannjjm 3973 2 dog dog NN cord-023095-4dannjjm 3973 3 in in IN cord-023095-4dannjjm 3973 4 the the DT cord-023095-4dannjjm 3973 5 O o NN cord-023095-4dannjjm 3973 6 group group NN cord-023095-4dannjjm 3973 7 with with IN cord-023095-4dannjjm 3973 8 ABUTI ABUTI NNP cord-023095-4dannjjm 3973 9 was be VBD cord-023095-4dannjjm 3973 10 close close JJ cord-023095-4dannjjm 3973 11 to to IN cord-023095-4dannjjm 3973 12 being be VBG cord-023095-4dannjjm 3973 13 MO MO NNP cord-023095-4dannjjm 3973 14 with with IN cord-023095-4dannjjm 3973 15 a a DT cord-023095-4dannjjm 3973 16 BF bf NN cord-023095-4dannjjm 3973 17 equaling equal VBG cord-023095-4dannjjm 3973 18 44.3 44.3 CD cord-023095-4dannjjm 3973 19 % % NN cord-023095-4dannjjm 3973 20 . . . cord-023095-4dannjjm 3974 1 Of of IN cord-023095-4dannjjm 3974 2 the the DT cord-023095-4dannjjm 3974 3 nine nine CD cord-023095-4dannjjm 3974 4 dogs dog NNS cord-023095-4dannjjm 3974 5 with with IN cord-023095-4dannjjm 3974 6 positive positive JJ cord-023095-4dannjjm 3974 7 cultures culture NNS cord-023095-4dannjjm 3974 8 , , , cord-023095-4dannjjm 3974 9 4 4 CD cord-023095-4dannjjm 3974 10 were be VBD cord-023095-4dannjjm 3974 11 neutered neuter VBN cord-023095-4dannjjm 3974 12 males male NNS cord-023095-4dannjjm 3974 13 and and CC cord-023095-4dannjjm 3974 14 5 5 CD cord-023095-4dannjjm 3974 15 were be VBD cord-023095-4dannjjm 3974 16 spayed spay VBN cord-023095-4dannjjm 3974 17 females female NNS cord-023095-4dannjjm 3974 18 . . . cord-023095-4dannjjm 3975 1 The the DT cord-023095-4dannjjm 3975 2 prevalence prevalence NN cord-023095-4dannjjm 3975 3 ratio ratio NN cord-023095-4dannjjm 3975 4 of of IN cord-023095-4dannjjm 3975 5 ABUTI ABUTI NNP cord-023095-4dannjjm 3975 6 in in IN cord-023095-4dannjjm 3975 7 MO MO NNP cord-023095-4dannjjm 3975 8 dogs dog NNS cord-023095-4dannjjm 3975 9 was be VBD cord-023095-4dannjjm 3975 10 7.5 7.5 CD cord-023095-4dannjjm 3975 11 , , , cord-023095-4dannjjm 3975 12 indicating indicate VBG cord-023095-4dannjjm 3975 13 dogs dog NNS cord-023095-4dannjjm 3975 14 with with IN cord-023095-4dannjjm 3975 15 45 45 CD cord-023095-4dannjjm 3975 16 % % NN cord-023095-4dannjjm 3975 17 or or CC cord-023095-4dannjjm 3975 18 greater great JJR cord-023095-4dannjjm 3975 19 BF bf NN cord-023095-4dannjjm 3975 20 are be VBP cord-023095-4dannjjm 3975 21 7.5 7.5 CD cord-023095-4dannjjm 3975 22 times time NNS cord-023095-4dannjjm 3975 23 more more RBR cord-023095-4dannjjm 3975 24 likely likely JJ cord-023095-4dannjjm 3975 25 to to TO cord-023095-4dannjjm 3975 26 have have VB cord-023095-4dannjjm 3975 27 the the DT cord-023095-4dannjjm 3975 28 condition condition NN cord-023095-4dannjjm 3975 29 then then RB cord-023095-4dannjjm 3975 30 dogs dog VBZ cord-023095-4dannjjm 3975 31 o o CD cord-023095-4dannjjm 3975 32 45 45 CD cord-023095-4dannjjm 3975 33 % % NN cord-023095-4dannjjm 3975 34 BF bf NN cord-023095-4dannjjm 3975 35 . . . cord-023095-4dannjjm 3976 1 The the DT cord-023095-4dannjjm 3976 2 results result NNS cord-023095-4dannjjm 3976 3 of of IN cord-023095-4dannjjm 3976 4 this this DT cord-023095-4dannjjm 3976 5 pilot pilot NN cord-023095-4dannjjm 3976 6 study study NN cord-023095-4dannjjm 3976 7 coincide coincide VB cord-023095-4dannjjm 3976 8 with with IN cord-023095-4dannjjm 3976 9 other other JJ cord-023095-4dannjjm 3976 10 surveillance surveillance NN cord-023095-4dannjjm 3976 11 data datum NNS cord-023095-4dannjjm 3976 12 describing describe VBG cord-023095-4dannjjm 3976 13 an an DT cord-023095-4dannjjm 3976 14 increased increase VBN cord-023095-4dannjjm 3976 15 prevalence prevalence NN cord-023095-4dannjjm 3976 16 of of IN cord-023095-4dannjjm 3976 17 lower low JJR cord-023095-4dannjjm 3976 18 urinary urinary JJ cord-023095-4dannjjm 3976 19 tract tract NN cord-023095-4dannjjm 3976 20 disease disease NN cord-023095-4dannjjm 3976 21 in in IN cord-023095-4dannjjm 3976 22 obese obese JJ cord-023095-4dannjjm 3976 23 dogs dog NNS cord-023095-4dannjjm 3976 24 . . . cord-023095-4dannjjm 3977 1 In in IN cord-023095-4dannjjm 3977 2 conclusion conclusion NN cord-023095-4dannjjm 3977 3 , , , cord-023095-4dannjjm 3977 4 dogs dog NNS cord-023095-4dannjjm 3977 5 with with IN cord-023095-4dannjjm 3977 6 body body NN cord-023095-4dannjjm 3977 7 fat fat NN cord-023095-4dannjjm 3977 8 percentages percentage NNS cord-023095-4dannjjm 3977 9 greater great JJR cord-023095-4dannjjm 3977 10 than than IN cord-023095-4dannjjm 3977 11 45 45 CD cord-023095-4dannjjm 3977 12 % % NN cord-023095-4dannjjm 3977 13 are be VBP cord-023095-4dannjjm 3977 14 at at IN cord-023095-4dannjjm 3977 15 risk risk NN cord-023095-4dannjjm 3977 16 for for IN cord-023095-4dannjjm 3977 17 ABUTI ABUTI NNP cord-023095-4dannjjm 3977 18 , , , cord-023095-4dannjjm 3977 19 and and CC cord-023095-4dannjjm 3977 20 veterinarians veterinarian NNS cord-023095-4dannjjm 3977 21 should should MD cord-023095-4dannjjm 3977 22 consider consider VB cord-023095-4dannjjm 3977 23 screening screen VBG cord-023095-4dannjjm 3977 24 all all DT cord-023095-4dannjjm 3977 25 morbidly morbidly RB cord-023095-4dannjjm 3977 26 obese obese JJ cord-023095-4dannjjm 3977 27 patients patient NNS cord-023095-4dannjjm 3977 28 for for IN cord-023095-4dannjjm 3977 29 urinary urinary JJ cord-023095-4dannjjm 3977 30 tract tract JJ cord-023095-4dannjjm 3977 31 infections infection NNS cord-023095-4dannjjm 3977 32 . . . cord-023095-4dannjjm 3978 1 Calcium calcium NN cord-023095-4dannjjm 3978 2 carbonate carbonate NN cord-023095-4dannjjm 3978 3 ( ( -LRB- cord-023095-4dannjjm 3978 4 CaC CaC NNP cord-023095-4dannjjm 3978 5 ) ) -RRB- cord-023095-4dannjjm 3978 6 is be VBZ cord-023095-4dannjjm 3978 7 recommended recommend VBN cord-023095-4dannjjm 3978 8 to to TO cord-023095-4dannjjm 3978 9 decrease decrease VB cord-023095-4dannjjm 3978 10 phosphate phosphate NN cord-023095-4dannjjm 3978 11 intake intake NN cord-023095-4dannjjm 3978 12 in in IN cord-023095-4dannjjm 3978 13 chronic chronic JJ cord-023095-4dannjjm 3978 14 kidney kidney NN cord-023095-4dannjjm 3978 15 disease disease NN cord-023095-4dannjjm 3978 16 . . . cord-023095-4dannjjm 3979 1 However however RB cord-023095-4dannjjm 3979 2 , , , cord-023095-4dannjjm 3979 3 its -PRON- PRP$ cord-023095-4dannjjm 3979 4 effect effect NN cord-023095-4dannjjm 3979 5 is be VBZ cord-023095-4dannjjm 3979 6 poorly poorly RB cord-023095-4dannjjm 3979 7 documented document VBN cord-023095-4dannjjm 3979 8 in in IN cord-023095-4dannjjm 3979 9 dogs dog NNS cord-023095-4dannjjm 3979 10 . . . cord-023095-4dannjjm 3980 1 Our -PRON- PRP$ cord-023095-4dannjjm 3980 2 objectives objective NNS cord-023095-4dannjjm 3980 3 were be VBD cord-023095-4dannjjm 3980 4 to to TO cord-023095-4dannjjm 3980 5 assess assess VB cord-023095-4dannjjm 3980 6 within within IN cord-023095-4dannjjm 3980 7 - - HYPH cord-023095-4dannjjm 3980 8 day day NN cord-023095-4dannjjm 3980 9 , , , cord-023095-4dannjjm 3980 10 postprandial postprandial JJ cord-023095-4dannjjm 3980 11 and and CC cord-023095-4dannjjm 3980 12 CaC CaC NNP cord-023095-4dannjjm 3980 13 effects effect NNS cord-023095-4dannjjm 3980 14 on on IN cord-023095-4dannjjm 3980 15 phosphatemia phosphatemia NN cord-023095-4dannjjm 3980 16 variations variation NNS cord-023095-4dannjjm 3980 17 in in IN cord-023095-4dannjjm 3980 18 healthy healthy JJ cord-023095-4dannjjm 3980 19 dogs dog NNS cord-023095-4dannjjm 3980 20 . . . cord-023095-4dannjjm 3981 1 Phosphatemia Phosphatemia NNP cord-023095-4dannjjm 3981 2 was be VBD cord-023095-4dannjjm 3981 3 measured measure VBN cord-023095-4dannjjm 3981 4 every every DT cord-023095-4dannjjm 3981 5 2 2 CD cord-023095-4dannjjm 3981 6 hours hour NNS cord-023095-4dannjjm 3981 7 for for IN cord-023095-4dannjjm 3981 8 24 24 CD cord-023095-4dannjjm 3981 9 hours hour NNS cord-023095-4dannjjm 3981 10 in in IN cord-023095-4dannjjm 3981 11 eight eight CD cord-023095-4dannjjm 3981 12 adult adult NN cord-023095-4dannjjm 3981 13 healthy healthy JJ cord-023095-4dannjjm 3981 14 Beagle Beagle NNP cord-023095-4dannjjm 3981 15 dogs dog NNS cord-023095-4dannjjm 3981 16 in in IN cord-023095-4dannjjm 3981 17 i i NN cord-023095-4dannjjm 3981 18 ) ) -RRB- cord-023095-4dannjjm 3981 19 fasted fast VBN cord-023095-4dannjjm 3981 20 condition condition NN cord-023095-4dannjjm 3981 21 and and CC cord-023095-4dannjjm 3981 22 ii ii LS cord-023095-4dannjjm 3981 23 ) ) -RRB- cord-023095-4dannjjm 3981 24 a a DT cord-023095-4dannjjm 3981 25 2 2 CD cord-023095-4dannjjm 3981 26 Â â CD cord-023095-4dannjjm 3981 27 2 2 CD cord-023095-4dannjjm 3981 28 crossover crossover NN cord-023095-4dannjjm 3981 29 design design NN cord-023095-4dannjjm 3981 30 . . . cord-023095-4dannjjm 3982 1 One one CD cord-023095-4dannjjm 3982 2 group group NN cord-023095-4dannjjm 3982 3 received receive VBD cord-023095-4dannjjm 3982 4 CaC CaC NNP cord-023095-4dannjjm 3982 5 mixed mix VBN cord-023095-4dannjjm 3982 6 with with IN cord-023095-4dannjjm 3982 7 maintenance maintenance NN cord-023095-4dannjjm 3982 8 diet diet NN cord-023095-4dannjjm 3982 9 ( ( -LRB- cord-023095-4dannjjm 3982 10 0.8 0.8 CD cord-023095-4dannjjm 3982 11 % % NN cord-023095-4dannjjm 3982 12 phosphorus phosphorus NN cord-023095-4dannjjm 3982 13 ) ) -RRB- cord-023095-4dannjjm 3982 14 , , , cord-023095-4dannjjm 3982 15 while while IN cord-023095-4dannjjm 3982 16 the the DT cord-023095-4dannjjm 3982 17 second second JJ cord-023095-4dannjjm 3982 18 group group NN cord-023095-4dannjjm 3982 19 received receive VBD cord-023095-4dannjjm 3982 20 the the DT cord-023095-4dannjjm 3982 21 diet diet NN cord-023095-4dannjjm 3982 22 alone alone RB cord-023095-4dannjjm 3982 23 . . . cord-023095-4dannjjm 3983 1 After after IN cord-023095-4dannjjm 3983 2 a a DT cord-023095-4dannjjm 3983 3 1-week 1-week CD cord-023095-4dannjjm 3983 4 wash wash NN cord-023095-4dannjjm 3983 5 - - HYPH cord-023095-4dannjjm 3983 6 out out RP cord-023095-4dannjjm 3983 7 period period NN cord-023095-4dannjjm 3983 8 , , , cord-023095-4dannjjm 3983 9 groups group NNS cord-023095-4dannjjm 3983 10 were be VBD cord-023095-4dannjjm 3983 11 switched switch VBN cord-023095-4dannjjm 3983 12 . . . cord-023095-4dannjjm 3984 1 A a DT cord-023095-4dannjjm 3984 2 general general JJ cord-023095-4dannjjm 3984 3 linear linear JJ cord-023095-4dannjjm 3984 4 model model NN cord-023095-4dannjjm 3984 5 was be VBD cord-023095-4dannjjm 3984 6 used use VBN cord-023095-4dannjjm 3984 7 to to TO cord-023095-4dannjjm 3984 8 test test VB cord-023095-4dannjjm 3984 9 the the DT cord-023095-4dannjjm 3984 10 period period NN cord-023095-4dannjjm 3984 11 , , , cord-023095-4dannjjm 3984 12 sequence sequence NN cord-023095-4dannjjm 3984 13 , , , cord-023095-4dannjjm 3984 14 treatment treatment NN cord-023095-4dannjjm 3984 15 , , , cord-023095-4dannjjm 3984 16 dog dog NN cord-023095-4dannjjm 3984 17 and and CC cord-023095-4dannjjm 3984 18 time time NN cord-023095-4dannjjm 3984 19 effects effect NNS cord-023095-4dannjjm 3984 20 on on IN cord-023095-4dannjjm 3984 21 phosphatemia phosphatemia NN cord-023095-4dannjjm 3984 22 and and CC cord-023095-4dannjjm 3984 23 the the DT cord-023095-4dannjjm 3984 24 area area NN cord-023095-4dannjjm 3984 25 under under IN cord-023095-4dannjjm 3984 26 the the DT cord-023095-4dannjjm 3984 27 phosphatemia phosphatemia NN cord-023095-4dannjjm 3984 28 versus versus IN cord-023095-4dannjjm 3984 29 time time NN cord-023095-4dannjjm 3984 30 curve curve NN cord-023095-4dannjjm 3984 31 ( ( -LRB- cord-023095-4dannjjm 3984 32 AUC AUC NNP cord-023095-4dannjjm 3984 33 0 0 CD cord-023095-4dannjjm 3984 34 - - HYPH cord-023095-4dannjjm 3984 35 24 24 CD cord-023095-4dannjjm 3984 36 ) ) -RRB- cord-023095-4dannjjm 3984 37 . . . cord-023095-4dannjjm 3985 1 A a DT cord-023095-4dannjjm 3985 2 significant significant JJ cord-023095-4dannjjm 3986 1 ( ( -LRB- cord-023095-4dannjjm 3986 2 p p NN cord-023095-4dannjjm 3986 3 o o CD cord-023095-4dannjjm 3986 4 0.001 0.001 CD cord-023095-4dannjjm 3986 5 ) ) -RRB- cord-023095-4dannjjm 3987 1 circadian circadian NN cord-023095-4dannjjm 3987 2 variation variation NN cord-023095-4dannjjm 3987 3 existed exist VBD cord-023095-4dannjjm 3987 4 in in IN cord-023095-4dannjjm 3987 5 fasted fast VBN cord-023095-4dannjjm 3987 6 dogs dog NNS cord-023095-4dannjjm 3987 7 . . . cord-023095-4dannjjm 3988 1 The the DT cord-023095-4dannjjm 3988 2 maximum maximum JJ cord-023095-4dannjjm 3988 3 difference difference NN cord-023095-4dannjjm 3988 4 ( ( -LRB- cord-023095-4dannjjm 3988 5 mean mean VB cord-023095-4dannjjm 3988 6 : : : cord-023095-4dannjjm 3988 7 À1.9 À1.9 NNP cord-023095-4dannjjm 3988 8 mg mg NNP cord-023095-4dannjjm 3988 9 / / SYM cord-023095-4dannjjm 3988 10 dL dl NN cord-023095-4dannjjm 3988 11 ; ; : cord-023095-4dannjjm 3988 12 95 95 CD cord-023095-4dannjjm 3988 13 % % NN cord-023095-4dannjjm 3988 14 C.I. C.I. NNP cord-023095-4dannjjm 3988 15 : : : cord-023095-4dannjjm 3988 16 À2.4 À2.4 NNP cord-023095-4dannjjm 3988 17 mg mg NNP cord-023095-4dannjjm 3988 18 / / SYM cord-023095-4dannjjm 3988 19 dL dl NN cord-023095-4dannjjm 3988 20 ; ; : cord-023095-4dannjjm 3989 1 À1.4 À1.4 NNP cord-023095-4dannjjm 3989 2 mg mg NNP cord-023095-4dannjjm 3989 3 / / SYM cord-023095-4dannjjm 3989 4 dL dL NNP cord-023095-4dannjjm 3989 5 ) ) -RRB- cord-023095-4dannjjm 3989 6 was be VBD cord-023095-4dannjjm 3989 7 observed observe VBN cord-023095-4dannjjm 3989 8 between between IN cord-023095-4dannjjm 3989 9 8 8 CD cord-023095-4dannjjm 3989 10 a.m. a.m. NN cord-023095-4dannjjm 3989 11 and and CC cord-023095-4dannjjm 3989 12 midnight midnight NN cord-023095-4dannjjm 3989 13 . . . cord-023095-4dannjjm 3990 1 The the DT cord-023095-4dannjjm 3990 2 AUC AUC NNP cord-023095-4dannjjm 3990 3 0 0 CD cord-023095-4dannjjm 3990 4 - - HYPH cord-023095-4dannjjm 3990 5 24 24 CD cord-023095-4dannjjm 3990 6 with with IN cord-023095-4dannjjm 3990 7 CaC CaC NNP cord-023095-4dannjjm 3990 8 ( ( -LRB- cord-023095-4dannjjm 3990 9 5936 5936 CD cord-023095-4dannjjm 3990 10 AE AE NNP cord-023095-4dannjjm 3990 11 533 533 CD cord-023095-4dannjjm 3990 12 mg.min/dL mg.min/dl ADD cord-023095-4dannjjm 3990 13 ) ) -RRB- cord-023095-4dannjjm 3990 14 was be VBD cord-023095-4dannjjm 3990 15 mildly mildly RB cord-023095-4dannjjm 3990 16 but but CC cord-023095-4dannjjm 3990 17 significantly significantly RB cord-023095-4dannjjm 3990 18 lower low JJR cord-023095-4dannjjm 3991 1 ( ( -LRB- cord-023095-4dannjjm 3991 2 p p NN cord-023095-4dannjjm 3991 3 5 5 CD cord-023095-4dannjjm 3991 4 0.027 0.027 CD cord-023095-4dannjjm 3991 5 ) ) -RRB- cord-023095-4dannjjm 3991 6 than than IN cord-023095-4dannjjm 3991 7 without without IN cord-023095-4dannjjm 3991 8 CaC CaC NNP cord-023095-4dannjjm 3991 9 ( ( -LRB- cord-023095-4dannjjm 3991 10 6239 6239 CD cord-023095-4dannjjm 3991 11 AE AE NNP cord-023095-4dannjjm 3991 12 631 631 CD cord-023095-4dannjjm 3991 13 mg.min/dL mg.min/dl ADD cord-023095-4dannjjm 3991 14 ) ) -RRB- cord-023095-4dannjjm 3991 15 . . . cord-023095-4dannjjm 3992 1 However however RB cord-023095-4dannjjm 3992 2 , , , cord-023095-4dannjjm 3992 3 it -PRON- PRP cord-023095-4dannjjm 3992 4 was be VBD cord-023095-4dannjjm 3992 5 similar similar JJ cord-023095-4dannjjm 3992 6 to to IN cord-023095-4dannjjm 3992 7 the the DT cord-023095-4dannjjm 3992 8 AUC AUC NNP cord-023095-4dannjjm 3992 9 0 0 CD cord-023095-4dannjjm 3992 10 - - SYM cord-023095-4dannjjm 3992 11 24 24 CD cord-023095-4dannjjm 3992 12 in in IN cord-023095-4dannjjm 3992 13 fasted fast VBN cord-023095-4dannjjm 3992 14 conditions condition NNS cord-023095-4dannjjm 3992 15 . . . cord-023095-4dannjjm 3993 1 Feeding feeding NN cord-023095-4dannjjm 3993 2 , , , cord-023095-4dannjjm 3993 3 with with IN cord-023095-4dannjjm 3993 4 and and CC cord-023095-4dannjjm 3993 5 without without IN cord-023095-4dannjjm 3993 6 CaC CaC NNP cord-023095-4dannjjm 3993 7 , , , cord-023095-4dannjjm 3993 8 has have VBZ cord-023095-4dannjjm 3993 9 minor minor JJ cord-023095-4dannjjm 3993 10 effect effect NN cord-023095-4dannjjm 3993 11 on on IN cord-023095-4dannjjm 3993 12 phosphatemia phosphatemia NN cord-023095-4dannjjm 3993 13 . . . cord-023095-4dannjjm 3994 1 However however RB cord-023095-4dannjjm 3994 2 , , , cord-023095-4dannjjm 3994 3 circadian circadian JJ cord-023095-4dannjjm 3994 4 variation variation NN cord-023095-4dannjjm 3994 5 of of IN cord-023095-4dannjjm 3994 6 fasted fast VBN cord-023095-4dannjjm 3994 7 phosphatemia phosphatemia NN cord-023095-4dannjjm 3994 8 might may MD cord-023095-4dannjjm 3994 9 affect affect VB cord-023095-4dannjjm 3994 10 its -PRON- PRP$ cord-023095-4dannjjm 3994 11 interpretation interpretation NN cord-023095-4dannjjm 3994 12 . . . cord-023095-4dannjjm 3995 1 GFR GFR NNP cord-023095-4dannjjm 3995 2 measurement measurement NN cord-023095-4dannjjm 3995 3 permits permit VBZ cord-023095-4dannjjm 3995 4 diagnosis diagnosis NN cord-023095-4dannjjm 3995 5 of of IN cord-023095-4dannjjm 3995 6 kidney kidney NN cord-023095-4dannjjm 3995 7 injury injury NN cord-023095-4dannjjm 3995 8 prior prior RB cord-023095-4dannjjm 3995 9 to to IN cord-023095-4dannjjm 3995 10 development development NN cord-023095-4dannjjm 3995 11 of of IN cord-023095-4dannjjm 3995 12 azotemia azotemia NN cord-023095-4dannjjm 3995 13 , , , cord-023095-4dannjjm 3995 14 and and CC cord-023095-4dannjjm 3995 15 is be VBZ cord-023095-4dannjjm 3995 16 the the DT cord-023095-4dannjjm 3995 17 gold gold NN cord-023095-4dannjjm 3995 18 standard standard NN cord-023095-4dannjjm 3995 19 for for IN cord-023095-4dannjjm 3995 20 kidney kidney NN cord-023095-4dannjjm 3995 21 function function NN cord-023095-4dannjjm 3995 22 assessment assessment NN cord-023095-4dannjjm 3995 23 . . . cord-023095-4dannjjm 3996 1 Accurate accurate JJ cord-023095-4dannjjm 3996 2 and and CC cord-023095-4dannjjm 3996 3 rapid rapid JJ cord-023095-4dannjjm 3996 4 ( ( -LRB- cord-023095-4dannjjm 3996 5 o o NN cord-023095-4dannjjm 3996 6 60 60 CD cord-023095-4dannjjm 3996 7 min min NN cord-023095-4dannjjm 3996 8 ) ) -RRB- cord-023095-4dannjjm 3996 9 GFR GFR NNP cord-023095-4dannjjm 3996 10 measurement measurement NN cord-023095-4dannjjm 3996 11 has have VBZ cord-023095-4dannjjm 3996 12 been be VBN cord-023095-4dannjjm 3996 13 performed perform VBN cord-023095-4dannjjm 3996 14 in in IN cord-023095-4dannjjm 3996 15 rats rat NNS cord-023095-4dannjjm 3996 16 by by IN cord-023095-4dannjjm 3996 17 simultaneous simultaneous JJ cord-023095-4dannjjm 3996 18 transcutaneous transcutaneous JJ cord-023095-4dannjjm 3996 19 assay assay NN cord-023095-4dannjjm 3996 20 of of IN cord-023095-4dannjjm 3996 21 two two CD cord-023095-4dannjjm 3996 22 intravascular intravascular JJ cord-023095-4dannjjm 3996 23 fluorescently fluorescently RB cord-023095-4dannjjm 3996 24 - - HYPH cord-023095-4dannjjm 3996 25 labeled label VBN cord-023095-4dannjjm 3996 26 markers marker NNS cord-023095-4dannjjm 3996 27 . . . cord-023095-4dannjjm 3997 1 A a DT cord-023095-4dannjjm 3997 2 recently recently RB cord-023095-4dannjjm 3997 3 developed develop VBN cord-023095-4dannjjm 3997 4 analyzer analyzer NN cord-023095-4dannjjm 3997 5 assays assay NNS cord-023095-4dannjjm 3997 6 fluorescence fluorescence NN cord-023095-4dannjjm 3997 7 via via IN cord-023095-4dannjjm 3997 8 a a DT cord-023095-4dannjjm 3997 9 fiberoptic fiberoptic JJ cord-023095-4dannjjm 3997 10 cable cable NN cord-023095-4dannjjm 3997 11 introduced introduce VBN cord-023095-4dannjjm 3997 12 through through IN cord-023095-4dannjjm 3997 13 a a DT cord-023095-4dannjjm 3997 14 peripheral peripheral JJ cord-023095-4dannjjm 3997 15 catheter catheter NN cord-023095-4dannjjm 3997 16 , , , cord-023095-4dannjjm 3997 17 and and CC cord-023095-4dannjjm 3997 18 thus thus RB cord-023095-4dannjjm 3997 19 should should MD cord-023095-4dannjjm 3997 20 also also RB cord-023095-4dannjjm 3997 21 allow allow VB cord-023095-4dannjjm 3997 22 rapid rapid JJ cord-023095-4dannjjm 3997 23 GFR GFR NNP cord-023095-4dannjjm 3997 24 determination determination NN cord-023095-4dannjjm 3997 25 in in IN cord-023095-4dannjjm 3997 26 larger large JJR cord-023095-4dannjjm 3997 27 species specie NNS cord-023095-4dannjjm 3997 28 . . . cord-023095-4dannjjm 3998 1 The the DT cord-023095-4dannjjm 3998 2 purpose purpose NN cord-023095-4dannjjm 3998 3 of of IN cord-023095-4dannjjm 3998 4 this this DT cord-023095-4dannjjm 3998 5 study study NN cord-023095-4dannjjm 3998 6 was be VBD cord-023095-4dannjjm 3998 7 to to TO cord-023095-4dannjjm 3998 8 determine determine VB cord-023095-4dannjjm 3998 9 correlation correlation NN cord-023095-4dannjjm 3998 10 and and CC cord-023095-4dannjjm 3998 11 agreement agreement NN cord-023095-4dannjjm 3998 12 between between IN cord-023095-4dannjjm 3998 13 fluorescent fluorescent NN cord-023095-4dannjjm 3998 14 ratiometry ratiometry NN cord-023095-4dannjjm 3998 15 ( ( -LRB- cord-023095-4dannjjm 3998 16 FR FR NNP cord-023095-4dannjjm 3998 17 ) ) -RRB- cord-023095-4dannjjm 3998 18 and and CC cord-023095-4dannjjm 3998 19 iohexol iohexol NN cord-023095-4dannjjm 3998 20 plasma plasma NN cord-023095-4dannjjm 3998 21 clearance clearance NN cord-023095-4dannjjm 3998 22 ( ( -LRB- cord-023095-4dannjjm 3998 23 IPC IPC NNP cord-023095-4dannjjm 3998 24 ) ) -RRB- cord-023095-4dannjjm 3998 25 in in IN cord-023095-4dannjjm 3998 26 dogs dog NNS cord-023095-4dannjjm 3998 27 over over IN cord-023095-4dannjjm 3998 28 a a DT cord-023095-4dannjjm 3998 29 range range NN cord-023095-4dannjjm 3998 30 of of IN cord-023095-4dannjjm 3998 31 GFRs gfr NNS cord-023095-4dannjjm 3998 32 . . . cord-023095-4dannjjm 3999 1 Acute acute JJ cord-023095-4dannjjm 3999 2 kidney kidney NN cord-023095-4dannjjm 3999 3 injury injury NN cord-023095-4dannjjm 3999 4 ( ( -LRB- cord-023095-4dannjjm 3999 5 AKI AKI NNP cord-023095-4dannjjm 3999 6 ) ) -RRB- cord-023095-4dannjjm 3999 7 was be VBD cord-023095-4dannjjm 3999 8 induced induce VBN cord-023095-4dannjjm 3999 9 in in IN cord-023095-4dannjjm 3999 10 5 5 CD cord-023095-4dannjjm 3999 11 female female JJ cord-023095-4dannjjm 3999 12 hound hound NN cord-023095-4dannjjm 3999 13 - - HYPH cord-023095-4dannjjm 3999 14 type type NN cord-023095-4dannjjm 3999 15 dogs dog NNS cord-023095-4dannjjm 3999 16 ( ( -LRB- cord-023095-4dannjjm 3999 17 10 10 CD cord-023095-4dannjjm 3999 18 mg mg NNP cord-023095-4dannjjm 3999 19 / / SYM cord-023095-4dannjjm 3999 20 kg kg NNP cord-023095-4dannjjm 3999 21 gentamicin gentamicin NNS cord-023095-4dannjjm 3999 22 IV IV NNP cord-023095-4dannjjm 3999 23 q8h q8h NNP cord-023095-4dannjjm 3999 24 ) ) -RRB- cord-023095-4dannjjm 3999 25 , , , cord-023095-4dannjjm 3999 26 and and CC cord-023095-4dannjjm 3999 27 FR FR NNP cord-023095-4dannjjm 3999 28 and and CC cord-023095-4dannjjm 3999 29 IPC IPC NNP cord-023095-4dannjjm 3999 30 GFR GFR NNP cord-023095-4dannjjm 3999 31 were be VBD cord-023095-4dannjjm 3999 32 simulta simulta NNP cord-023095-4dannjjm 3999 33 - - HYPH cord-023095-4dannjjm 3999 34 neously neously NNP cord-023095-4dannjjm 3999 35 determined determine VBN cord-023095-4dannjjm 3999 36 on on IN cord-023095-4dannjjm 3999 37 days day NNS cord-023095-4dannjjm 3999 38 0 0 CD cord-023095-4dannjjm 3999 39 , , , cord-023095-4dannjjm 3999 40 3 3 CD cord-023095-4dannjjm 3999 41 , , , cord-023095-4dannjjm 3999 42 6 6 CD cord-023095-4dannjjm 3999 43 and and CC cord-023095-4dannjjm 3999 44 9 9 CD cord-023095-4dannjjm 3999 45 . . . cord-023095-4dannjjm 4000 1 A a DT cord-023095-4dannjjm 4000 2 9-sample 9-sample CD cord-023095-4dannjjm 4000 3 , , , cord-023095-4dannjjm 4000 4 5-hr 5-hr CD cord-023095-4dannjjm 4000 5 protocol protocol NN cord-023095-4dannjjm 4000 6 was be VBD cord-023095-4dannjjm 4000 7 used use VBN cord-023095-4dannjjm 4000 8 for for IN cord-023095-4dannjjm 4000 9 IPC IPC NNP cord-023095-4dannjjm 4000 10 ; ; : cord-023095-4dannjjm 4000 11 FR FR NNP cord-023095-4dannjjm 4000 12 was be VBD cord-023095-4dannjjm 4000 13 determined determine VBN cord-023095-4dannjjm 4000 14 following follow VBG cord-023095-4dannjjm 4000 15 bolus bolus NN cord-023095-4dannjjm 4000 16 injection injection NN cord-023095-4dannjjm 4000 17 of of IN cord-023095-4dannjjm 4000 18 a a DT cord-023095-4dannjjm 4000 19 dextran dextran NN cord-023095-4dannjjm 4000 20 conjugate conjugate NN cord-023095-4dannjjm 4000 21 mixture mixture NN cord-023095-4dannjjm 4000 22 ( ( -LRB- cord-023095-4dannjjm 4000 23 2-sulfohexamine 2-sulfohexamine CD cord-023095-4dannjjm 4000 24 rhodamine rhodamine NN cord-023095-4dannjjm 4000 25 - - HYPH cord-023095-4dannjjm 4000 26 carboxymethyl carboxymethyl NN cord-023095-4dannjjm 4000 27 150 150 CD cord-023095-4dannjjm 4000 28 kD kd JJ cord-023095-4dannjjm 4000 29 dextran dextran NN cord-023095-4dannjjm 4000 30 , , , cord-023095-4dannjjm 4000 31 5-aminofluorescein 5-aminofluorescein CD cord-023095-4dannjjm 4000 32 - - HYPH cord-023095-4dannjjm 4000 33 carboxymethyl carboxymethyl NNP cord-023095-4dannjjm 4000 34 5 5 CD cord-023095-4dannjjm 4000 35 kD kd JJ cord-023095-4dannjjm 4000 36 dextran dextran NN cord-023095-4dannjjm 4000 37 ) ) -RRB- cord-023095-4dannjjm 4000 38 with with IN cord-023095-4dannjjm 4000 39 fluorescence fluorescence NN cord-023095-4dannjjm 4000 40 measured measure VBN cord-023095-4dannjjm 4000 41 over over IN cord-023095-4dannjjm 4000 42 60 60 CD cord-023095-4dannjjm 4000 43 min min NN cord-023095-4dannjjm 4000 44 . . . cord-023095-4dannjjm 4001 1 GFR GFR NNP cord-023095-4dannjjm 4001 2 was be VBD cord-023095-4dannjjm 4001 3 calculated calculate VBN cord-023095-4dannjjm 4001 4 using use VBG cord-023095-4dannjjm 4001 5 2-compartment 2-compartment CD cord-023095-4dannjjm 4001 6 model model NN cord-023095-4dannjjm 4001 7 concentration concentration NN cord-023095-4dannjjm 4001 8 - - HYPH cord-023095-4dannjjm 4001 9 vs.-time vs.-time NN cord-023095-4dannjjm 4001 10 curves curve NNS cord-023095-4dannjjm 4001 11 for for IN cord-023095-4dannjjm 4001 12 both both DT cord-023095-4dannjjm 4001 13 techniques technique NNS cord-023095-4dannjjm 4001 14 . . . cord-023095-4dannjjm 4002 1 Correlation correlation NN cord-023095-4dannjjm 4002 2 was be VBD cord-023095-4dannjjm 4002 3 determined determine VBN cord-023095-4dannjjm 4002 4 via via IN cord-023095-4dannjjm 4002 5 Spearman Spearman NNP cord-023095-4dannjjm 4002 6 's 's POS cord-023095-4dannjjm 4002 7 rho rho NN cord-023095-4dannjjm 4002 8 ; ; : cord-023095-4dannjjm 4002 9 agreement agreement NN cord-023095-4dannjjm 4002 10 was be VBD cord-023095-4dannjjm 4002 11 analyzed analyze VBN cord-023095-4dannjjm 4002 12 via via IN cord-023095-4dannjjm 4002 13 Bland Bland NNP cord-023095-4dannjjm 4002 14 - - HYPH cord-023095-4dannjjm 4002 15 Altman Altman NNP cord-023095-4dannjjm 4002 16 plots plot NNS cord-023095-4dannjjm 4002 17 . . . cord-023095-4dannjjm 4003 1 IPC IPC NNP cord-023095-4dannjjm 4003 2 GFR GFR NNP cord-023095-4dannjjm 4003 3 and and CC cord-023095-4dannjjm 4003 4 serum serum NN cord-023095-4dannjjm 4003 5 creatinine creatinine NN cord-023095-4dannjjm 4003 6 confirmed confirm VBD cord-023095-4dannjjm 4003 7 progressive progressive JJ cord-023095-4dannjjm 4003 8 AKI AKI NNP cord-023095-4dannjjm 4003 9 in in IN cord-023095-4dannjjm 4003 10 all all DT cord-023095-4dannjjm 4003 11 dogs dog NNS cord-023095-4dannjjm 4003 12 . . . cord-023095-4dannjjm 4004 1 Correlation correlation NN cord-023095-4dannjjm 4004 2 between between IN cord-023095-4dannjjm 4004 3 FR FR NNP cord-023095-4dannjjm 4004 4 and and CC cord-023095-4dannjjm 4004 5 IPC IPC NNP cord-023095-4dannjjm 4004 6 was be VBD cord-023095-4dannjjm 4004 7 0.91 0.91 CD cord-023095-4dannjjm 4005 1 ( ( -LRB- cord-023095-4dannjjm 4005 2 p p NN cord-023095-4dannjjm 4005 3 o o CD cord-023095-4dannjjm 4005 4 0.001 0.001 CD cord-023095-4dannjjm 4005 5 ) ) -RRB- cord-023095-4dannjjm 4005 6 . . . cord-023095-4dannjjm 4006 1 Bland Bland NNP cord-023095-4dannjjm 4006 2 - - HYPH cord-023095-4dannjjm 4006 3 Altman Altman NNP cord-023095-4dannjjm 4006 4 plots plot NNS cord-023095-4dannjjm 4006 5 confirmed confirm VBD cord-023095-4dannjjm 4006 6 good good JJ cord-023095-4dannjjm 4006 7 agreement agreement NN cord-023095-4dannjjm 4006 8 between between IN cord-023095-4dannjjm 4006 9 techniques technique NNS cord-023095-4dannjjm 4006 10 with with IN cord-023095-4dannjjm 4006 11 slight slight JJ cord-023095-4dannjjm 4006 12 underestimation underestimation NN cord-023095-4dannjjm 4006 13 of of IN cord-023095-4dannjjm 4006 14 GFR GFR NNP cord-023095-4dannjjm 4006 15 by by IN cord-023095-4dannjjm 4006 16 FR FR NNP cord-023095-4dannjjm 4006 17 across across IN cord-023095-4dannjjm 4006 18 most most RBS cord-023095-4dannjjm 4006 19 observed observe VBN cord-023095-4dannjjm 4006 20 values value NNS cord-023095-4dannjjm 4006 21 . . . cord-023095-4dannjjm 4007 1 These these DT cord-023095-4dannjjm 4007 2 results result NNS cord-023095-4dannjjm 4007 3 suggest suggest VBP cord-023095-4dannjjm 4007 4 FR FR NNP cord-023095-4dannjjm 4007 5 is be VBZ cord-023095-4dannjjm 4007 6 suitable suitable JJ cord-023095-4dannjjm 4007 7 for for IN cord-023095-4dannjjm 4007 8 GFR GFR NNP cord-023095-4dannjjm 4007 9 determination determination NN cord-023095-4dannjjm 4007 10 in in IN cord-023095-4dannjjm 4007 11 dogs dog NNS cord-023095-4dannjjm 4007 12 with with IN cord-023095-4dannjjm 4007 13 AKI AKI NNP cord-023095-4dannjjm 4007 14 . . . cord-023095-4dannjjm 4008 1 Importantly importantly RB cord-023095-4dannjjm 4008 2 , , , cord-023095-4dannjjm 4008 3 the the DT cord-023095-4dannjjm 4008 4 portable portable JJ cord-023095-4dannjjm 4008 5 analyzer analyzer NN cord-023095-4dannjjm 4008 6 allowed allow VBN cord-023095-4dannjjm 4008 7 for for IN cord-023095-4dannjjm 4008 8 point point NN cord-023095-4dannjjm 4008 9 - - HYPH cord-023095-4dannjjm 4008 10 of of IN cord-023095-4dannjjm 4008 11 - - HYPH cord-023095-4dannjjm 4008 12 care care NN cord-023095-4dannjjm 4008 13 GFR GFR NNP cord-023095-4dannjjm 4008 14 determination determination NN cord-023095-4dannjjm 4008 15 in in IN cord-023095-4dannjjm 4008 16 o o NN cord-023095-4dannjjm 4008 17 60 60 CD cord-023095-4dannjjm 4008 18 min min NN cord-023095-4dannjjm 4008 19 using use VBG cord-023095-4dannjjm 4008 20 a a DT cord-023095-4dannjjm 4008 21 peripheral peripheral JJ cord-023095-4dannjjm 4008 22 vein vein NN cord-023095-4dannjjm 4008 23 . . . cord-023095-4dannjjm 4009 1 Previously previously RB cord-023095-4dannjjm 4009 2 presented present VBN cord-023095-4dannjjm 4009 3 at at IN cord-023095-4dannjjm 4009 4 the the DT cord-023095-4dannjjm 4009 5 American American NNP cord-023095-4dannjjm 4009 6 Society Society NNP cord-023095-4dannjjm 4009 7 of of IN cord-023095-4dannjjm 4009 8 Nephrology Nephrology NNP cord-023095-4dannjjm 4009 9 Renal Renal NNP cord-023095-4dannjjm 4009 10 Week Week NNP cord-023095-4dannjjm 4009 11 ( ( -LRB- cord-023095-4dannjjm 4009 12 related relate VBN cord-023095-4dannjjm 4009 13 but but CC cord-023095-4dannjjm 4009 14 not not RB cord-023095-4dannjjm 4009 15 identical identical JJ cord-023095-4dannjjm 4009 16 abstract abstract JJ cord-023095-4dannjjm 4009 17 ) ) -RRB- cord-023095-4dannjjm 4009 18 . . . cord-023095-4dannjjm 4010 1 Dogs dog NNS cord-023095-4dannjjm 4010 2 with with IN cord-023095-4dannjjm 4010 3 protein protein NN cord-023095-4dannjjm 4010 4 - - HYPH cord-023095-4dannjjm 4010 5 losing lose VBG cord-023095-4dannjjm 4010 6 nephropathy nephropathy NN cord-023095-4dannjjm 4010 7 ( ( -LRB- cord-023095-4dannjjm 4010 8 PLN PLN NNP cord-023095-4dannjjm 4010 9 ) ) -RRB- cord-023095-4dannjjm 4010 10 are be VBP cord-023095-4dannjjm 4010 11 at at IN cord-023095-4dannjjm 4010 12 risk risk NN cord-023095-4dannjjm 4010 13 of of IN cord-023095-4dannjjm 4010 14 thromboembolic thromboembolic JJ cord-023095-4dannjjm 4010 15 disease disease NN cord-023095-4dannjjm 4010 16 , , , cord-023095-4dannjjm 4010 17 but but CC cord-023095-4dannjjm 4010 18 the the DT cord-023095-4dannjjm 4010 19 mechanism mechanism NN cord-023095-4dannjjm 4010 20 of of IN cord-023095-4dannjjm 4010 21 hypercoagulability hypercoagulability NN cord-023095-4dannjjm 4010 22 and and CC cord-023095-4dannjjm 4010 23 the the DT cord-023095-4dannjjm 4010 24 population population NN cord-023095-4dannjjm 4010 25 of of IN cord-023095-4dannjjm 4010 26 dogs dog NNS cord-023095-4dannjjm 4010 27 at at IN cord-023095-4dannjjm 4010 28 risk risk NN cord-023095-4dannjjm 4010 29 are be VBP cord-023095-4dannjjm 4010 30 unknown unknown JJ cord-023095-4dannjjm 4010 31 . . . cord-023095-4dannjjm 4011 1 The the DT cord-023095-4dannjjm 4011 2 purpose purpose NN cord-023095-4dannjjm 4011 3 of of IN cord-023095-4dannjjm 4011 4 this this DT cord-023095-4dannjjm 4011 5 study study NN cord-023095-4dannjjm 4011 6 was be VBD cord-023095-4dannjjm 4011 7 to to TO cord-023095-4dannjjm 4011 8 characterize characterize VB cord-023095-4dannjjm 4011 9 thromboelastography thromboelastography NNP cord-023095-4dannjjm 4011 10 ( ( -LRB- cord-023095-4dannjjm 4011 11 TEG TEG NNP cord-023095-4dannjjm 4011 12 ) ) -RRB- cord-023095-4dannjjm 4011 13 in in IN cord-023095-4dannjjm 4011 14 dogs dog NNS cord-023095-4dannjjm 4011 15 with with IN cord-023095-4dannjjm 4011 16 PLN PLN NNP cord-023095-4dannjjm 4011 17 . . . cord-023095-4dannjjm 4012 1 Twenty twenty CD cord-023095-4dannjjm 4012 2 - - HYPH cord-023095-4dannjjm 4012 3 eight eight CD cord-023095-4dannjjm 4012 4 client client NN cord-023095-4dannjjm 4012 5 - - HYPH cord-023095-4dannjjm 4012 6 owned own VBN cord-023095-4dannjjm 4012 7 dogs dog NNS cord-023095-4dannjjm 4012 8 with with IN cord-023095-4dannjjm 4012 9 PLN PLN NNP cord-023095-4dannjjm 4012 10 ( ( -LRB- cord-023095-4dannjjm 4012 11 urine urine NN cord-023095-4dannjjm 4012 12 protein protein NN cord-023095-4dannjjm 4012 13 : : : cord-023095-4dannjjm 4012 14 creatinine creatinine NN cord-023095-4dannjjm 4012 15 ratio ratio NN cord-023095-4dannjjm 4012 16 ( ( -LRB- cord-023095-4dannjjm 4012 17 UPC UPC NNP cord-023095-4dannjjm 4012 18 ) ) -RRB- cord-023095-4dannjjm 4012 19 4 4 CD cord-023095-4dannjjm 4012 20 2.0 2.0 CD cord-023095-4dannjjm 4012 21 ) ) -RRB- cord-023095-4dannjjm 4012 22 and and CC cord-023095-4dannjjm 4012 23 8 8 CD cord-023095-4dannjjm 4012 24 control control NN cord-023095-4dannjjm 4012 25 dogs dog NNS cord-023095-4dannjjm 4012 26 were be VBD cord-023095-4dannjjm 4012 27 enrolled enrol VBN cord-023095-4dannjjm 4012 28 . . . cord-023095-4dannjjm 4013 1 TEG TEG NNP cord-023095-4dannjjm 4013 2 parameters parameter NNS cord-023095-4dannjjm 4013 3 , , , cord-023095-4dannjjm 4013 4 antithrombin antithrombin NN cord-023095-4dannjjm 4013 5 activity activity NN cord-023095-4dannjjm 4013 6 , , , cord-023095-4dannjjm 4013 7 serum serum NN cord-023095-4dannjjm 4013 8 biochemical biochemical JJ cord-023095-4dannjjm 4013 9 profiles profile NNS cord-023095-4dannjjm 4013 10 , , , cord-023095-4dannjjm 4013 11 and and CC cord-023095-4dannjjm 4013 12 UPC UPC NNP cord-023095-4dannjjm 4013 13 were be VBD cord-023095-4dannjjm 4013 14 measured measure VBN cord-023095-4dannjjm 4013 15 . . . cord-023095-4dannjjm 4014 1 TEG TEG NNP cord-023095-4dannjjm 4014 2 analyses analysis NNS cord-023095-4dannjjm 4014 3 were be VBD cord-023095-4dannjjm 4014 4 run run VBN cord-023095-4dannjjm 4014 5 in in IN cord-023095-4dannjjm 4014 6 duplicate duplicate NN cord-023095-4dannjjm 4014 7 with with IN cord-023095-4dannjjm 4014 8 kaolin kaolin NN cord-023095-4dannjjm 4014 9 activation activation NN cord-023095-4dannjjm 4014 10 ; ; : cord-023095-4dannjjm 4014 11 reaction reaction NN cord-023095-4dannjjm 4014 12 time time NN cord-023095-4dannjjm 4014 13 ( ( -LRB- cord-023095-4dannjjm 4014 14 R r NN cord-023095-4dannjjm 4014 15 ) ) -RRB- cord-023095-4dannjjm 4014 16 , , , cord-023095-4dannjjm 4014 17 clot clot NN cord-023095-4dannjjm 4014 18 formation formation NN cord-023095-4dannjjm 4014 19 time time NN cord-023095-4dannjjm 4014 20 ( ( -LRB- cord-023095-4dannjjm 4014 21 K K NNP cord-023095-4dannjjm 4014 22 ) ) -RRB- cord-023095-4dannjjm 4014 23 , , , cord-023095-4dannjjm 4014 24 maximal maximal JJ cord-023095-4dannjjm 4014 25 amplitude amplitude NN cord-023095-4dannjjm 4014 26 ( ( -LRB- cord-023095-4dannjjm 4014 27 MA MA NNP cord-023095-4dannjjm 4014 28 ) ) -RRB- cord-023095-4dannjjm 4014 29 , , , cord-023095-4dannjjm 4014 30 and and CC cord-023095-4dannjjm 4014 31 G G NNP cord-023095-4dannjjm 4014 32 ( ( -LRB- cord-023095-4dannjjm 4014 33 global global JJ cord-023095-4dannjjm 4014 34 clot clot NN cord-023095-4dannjjm 4014 35 strength strength NN cord-023095-4dannjjm 4014 36 ) ) -RRB- cord-023095-4dannjjm 4014 37 were be VBD cord-023095-4dannjjm 4014 38 analyzed analyze VBN cord-023095-4dannjjm 4014 39 . . . cord-023095-4dannjjm 4015 1 A a DT cord-023095-4dannjjm 4015 2 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 4015 3 Sum Sum NNP cord-023095-4dannjjm 4015 4 Rank Rank NNP cord-023095-4dannjjm 4015 5 Test Test NNP cord-023095-4dannjjm 4015 6 was be VBD cord-023095-4dannjjm 4015 7 used use VBN cord-023095-4dannjjm 4015 8 to to TO cord-023095-4dannjjm 4015 9 evaluate evaluate VB cord-023095-4dannjjm 4015 10 differences difference NNS cord-023095-4dannjjm 4015 11 between between IN cord-023095-4dannjjm 4015 12 groups group NNS cord-023095-4dannjjm 4015 13 . . . cord-023095-4dannjjm 4016 1 Twelve twelve CD cord-023095-4dannjjm 4016 2 PLN PLN NNP cord-023095-4dannjjm 4016 3 dogs dog NNS cord-023095-4dannjjm 4016 4 ( ( -LRB- cord-023095-4dannjjm 4016 5 42.8 42.8 CD cord-023095-4dannjjm 4016 6 % % NN cord-023095-4dannjjm 4016 7 ) ) -RRB- cord-023095-4dannjjm 4016 8 were be VBD cord-023095-4dannjjm 4016 9 azotemic azotemic JJ cord-023095-4dannjjm 4016 10 . . . cord-023095-4dannjjm 4017 1 Nineteen nineteen CD cord-023095-4dannjjm 4017 2 PLN PLN NNP cord-023095-4dannjjm 4017 3 dogs dog NNS cord-023095-4dannjjm 4017 4 ( ( -LRB- cord-023095-4dannjjm 4017 5 67.8 67.8 CD cord-023095-4dannjjm 4017 6 % % NN cord-023095-4dannjjm 4017 7 ) ) -RRB- cord-023095-4dannjjm 4017 8 were be VBD cord-023095-4dannjjm 4017 9 hypoalbuminemic hypoalbuminemic JJ cord-023095-4dannjjm 4017 10 [ [ -LRB- cord-023095-4dannjjm 4017 11 serum serum NN cord-023095-4dannjjm 4017 12 albumin albumin NN cord-023095-4dannjjm 4017 13 ( ( -LRB- cord-023095-4dannjjm 4017 14 SALB SALB NNP cord-023095-4dannjjm 4017 15 ) ) -RRB- cord-023095-4dannjjm 4018 1 o o LS cord-023095-4dannjjm 4018 2 3.0 3.0 CD cord-023095-4dannjjm 4018 3 g g NN cord-023095-4dannjjm 4018 4 / / SYM cord-023095-4dannjjm 4018 5 dl dl NN cord-023095-4dannjjm 4018 6 ] ] -RRB- cord-023095-4dannjjm 4018 7 ; ; : cord-023095-4dannjjm 4018 8 11 11 CD cord-023095-4dannjjm 4018 9 had have VBD cord-023095-4dannjjm 4018 10 SALB SALB NNP cord-023095-4dannjjm 4018 11 o o NN cord-023095-4dannjjm 4018 12 2.5 2.5 CD cord-023095-4dannjjm 4018 13 g g NN cord-023095-4dannjjm 4018 14 / / SYM cord-023095-4dannjjm 4018 15 dl dl NN cord-023095-4dannjjm 4018 16 . . . cord-023095-4dannjjm 4019 1 Dogs dog NNS cord-023095-4dannjjm 4019 2 with with IN cord-023095-4dannjjm 4019 3 PLN PLN NNP cord-023095-4dannjjm 4019 4 had have VBD cord-023095-4dannjjm 4019 5 higher high JJR cord-023095-4dannjjm 4019 6 K k NN cord-023095-4dannjjm 4019 7 ( ( -LRB- cord-023095-4dannjjm 4019 8 p p NN cord-023095-4dannjjm 4019 9 o o NN cord-023095-4dannjjm 4019 10 0.01 0.01 CD cord-023095-4dannjjm 4019 11 ) ) -RRB- cord-023095-4dannjjm 4019 12 , , , cord-023095-4dannjjm 4019 13 MA MA NNP cord-023095-4dannjjm 4019 14 ( ( -LRB- cord-023095-4dannjjm 4019 15 p p NN cord-023095-4dannjjm 4019 16 o o NN cord-023095-4dannjjm 4019 17 0.005 0.005 CD cord-023095-4dannjjm 4019 18 ) ) -RRB- cord-023095-4dannjjm 4019 19 and and CC cord-023095-4dannjjm 4019 20 G g NN cord-023095-4dannjjm 4019 21 ( ( -LRB- cord-023095-4dannjjm 4019 22 p p NN cord-023095-4dannjjm 4019 23 o o NN cord-023095-4dannjjm 4019 24 0.005 0.005 CD cord-023095-4dannjjm 4019 25 ) ) -RRB- cord-023095-4dannjjm 4019 26 than than IN cord-023095-4dannjjm 4019 27 controls control NNS cord-023095-4dannjjm 4019 28 . . . cord-023095-4dannjjm 4020 1 R r NN cord-023095-4dannjjm 4020 2 was be VBD cord-023095-4dannjjm 4020 3 similar similar JJ cord-023095-4dannjjm 4020 4 between between IN cord-023095-4dannjjm 4020 5 the the DT cord-023095-4dannjjm 4020 6 two two CD cord-023095-4dannjjm 4020 7 groups group NNS cord-023095-4dannjjm 4020 8 . . . cord-023095-4dannjjm 4021 1 PLN PLN NNP cord-023095-4dannjjm 4021 2 dogs dog NNS cord-023095-4dannjjm 4021 3 with with IN cord-023095-4dannjjm 4021 4 SALB SALB NNP cord-023095-4dannjjm 4021 5 o o NN cord-023095-4dannjjm 4022 1 2.5 2.5 CD cord-023095-4dannjjm 4022 2 g g NN cord-023095-4dannjjm 4022 3 / / SYM cord-023095-4dannjjm 4022 4 dl dl NNP cord-023095-4dannjjm 4022 5 had have VBD cord-023095-4dannjjm 4022 6 higher high JJR cord-023095-4dannjjm 4022 7 G g NN cord-023095-4dannjjm 4022 8 ( ( -LRB- cord-023095-4dannjjm 4022 9 p p NN cord-023095-4dannjjm 4022 10 o o NN cord-023095-4dannjjm 4022 11 0.05 0.05 CD cord-023095-4dannjjm 4022 12 ) ) -RRB- cord-023095-4dannjjm 4022 13 values value NNS cord-023095-4dannjjm 4022 14 than than IN cord-023095-4dannjjm 4022 15 dogs dog NNS cord-023095-4dannjjm 4022 16 with with IN cord-023095-4dannjjm 4022 17 SALB SALB NNP cord-023095-4dannjjm 4022 18 4 4 CD cord-023095-4dannjjm 4022 19 2.5 2.5 CD cord-023095-4dannjjm 4022 20 g g NN cord-023095-4dannjjm 4022 21 / / SYM cord-023095-4dannjjm 4022 22 dl dl NN cord-023095-4dannjjm 4022 23 ; ; : cord-023095-4dannjjm 4022 24 however however RB cord-023095-4dannjjm 4022 25 , , , cord-023095-4dannjjm 4022 26 even even RB cord-023095-4dannjjm 4022 27 PLN PLN NNP cord-023095-4dannjjm 4022 28 dogs dog NNS cord-023095-4dannjjm 4022 29 with with IN cord-023095-4dannjjm 4022 30 normal normal JJ cord-023095-4dannjjm 4022 31 SALB SALB NNP cord-023095-4dannjjm 4022 32 ( ( -LRB- cord-023095-4dannjjm 4022 33 4 4 CD cord-023095-4dannjjm 4022 34 3.0 3.0 CD cord-023095-4dannjjm 4022 35 g g NN cord-023095-4dannjjm 4022 36 / / SYM cord-023095-4dannjjm 4022 37 dl dl NN cord-023095-4dannjjm 4022 38 ) ) -RRB- cord-023095-4dannjjm 4022 39 had have VBD cord-023095-4dannjjm 4022 40 significantly significantly RB cord-023095-4dannjjm 4022 41 higher high JJR cord-023095-4dannjjm 4022 42 G g NN cord-023095-4dannjjm 4022 43 values value NNS cord-023095-4dannjjm 4022 44 than than IN cord-023095-4dannjjm 4022 45 controls control NNS cord-023095-4dannjjm 4023 1 ( ( -LRB- cord-023095-4dannjjm 4023 2 p p NN cord-023095-4dannjjm 4023 3 o o NN cord-023095-4dannjjm 4023 4 0.005 0.005 CD cord-023095-4dannjjm 4023 5 ) ) -RRB- cord-023095-4dannjjm 4023 6 . . . cord-023095-4dannjjm 4024 1 No no DT cord-023095-4dannjjm 4024 2 significant significant JJ cord-023095-4dannjjm 4024 3 relationship relationship NN cord-023095-4dannjjm 4024 4 between between IN cord-023095-4dannjjm 4024 5 UPC UPC NNP cord-023095-4dannjjm 4024 6 and and CC cord-023095-4dannjjm 4024 7 G G NNP cord-023095-4dannjjm 4024 8 , , , cord-023095-4dannjjm 4024 9 SALB SALB NNP cord-023095-4dannjjm 4024 10 and and CC cord-023095-4dannjjm 4024 11 G G NNP cord-023095-4dannjjm 4024 12 , , , cord-023095-4dannjjm 4024 13 antithrombin antithrombin NN cord-023095-4dannjjm 4024 14 and and CC cord-023095-4dannjjm 4024 15 G G NNP cord-023095-4dannjjm 4024 16 , , , cord-023095-4dannjjm 4024 17 or or CC cord-023095-4dannjjm 4024 18 SALB SALB NNP cord-023095-4dannjjm 4024 19 and and CC cord-023095-4dannjjm 4024 20 antithrombin antithrombin NN cord-023095-4dannjjm 4024 21 was be VBD cord-023095-4dannjjm 4024 22 noted note VBN cord-023095-4dannjjm 4024 23 using use VBG cord-023095-4dannjjm 4024 24 linear linear JJ cord-023095-4dannjjm 4024 25 regression regression NN cord-023095-4dannjjm 4024 26 analysis analysis NN cord-023095-4dannjjm 4024 27 . . . cord-023095-4dannjjm 4025 1 These these DT cord-023095-4dannjjm 4025 2 results result NNS cord-023095-4dannjjm 4025 3 indicate indicate VBP cord-023095-4dannjjm 4025 4 that that IN cord-023095-4dannjjm 4025 5 antithrombin antithrombin NN cord-023095-4dannjjm 4025 6 , , , cord-023095-4dannjjm 4025 7 SALB SALB NNP cord-023095-4dannjjm 4025 8 , , , cord-023095-4dannjjm 4025 9 and and CC cord-023095-4dannjjm 4025 10 UPC UPC NNP cord-023095-4dannjjm 4025 11 can can MD cord-023095-4dannjjm 4025 12 not not RB cord-023095-4dannjjm 4025 13 be be VB cord-023095-4dannjjm 4025 14 used use VBN cord-023095-4dannjjm 4025 15 alone alone RB cord-023095-4dannjjm 4025 16 to to TO cord-023095-4dannjjm 4025 17 predict predict VB cord-023095-4dannjjm 4025 18 hypercoagulability hypercoagulability NN cord-023095-4dannjjm 4025 19 as as IN cord-023095-4dannjjm 4025 20 assessed assess VBN cord-023095-4dannjjm 4025 21 by by IN cord-023095-4dannjjm 4025 22 TEG TEG NNP cord-023095-4dannjjm 4025 23 in in IN cord-023095-4dannjjm 4025 24 dogs dog NNS cord-023095-4dannjjm 4025 25 with with IN cord-023095-4dannjjm 4025 26 PLN PLN NNP cord-023095-4dannjjm 4025 27 . . . cord-023095-4dannjjm 4026 1 A a DT cord-023095-4dannjjm 4026 2 comprehensive comprehensive JJ cord-023095-4dannjjm 4026 3 evaluation evaluation NN cord-023095-4dannjjm 4026 4 of of IN cord-023095-4dannjjm 4026 5 the the DT cord-023095-4dannjjm 4026 6 coagulation coagulation NN cord-023095-4dannjjm 4026 7 system system NN cord-023095-4dannjjm 4026 8 in in IN cord-023095-4dannjjm 4026 9 individual individual JJ cord-023095-4dannjjm 4026 10 patients patient NNS cord-023095-4dannjjm 4026 11 may may MD cord-023095-4dannjjm 4026 12 be be VB cord-023095-4dannjjm 4026 13 necessary necessary JJ cord-023095-4dannjjm 4026 14 to to TO cord-023095-4dannjjm 4026 15 predict predict VB cord-023095-4dannjjm 4026 16 the the DT cord-023095-4dannjjm 4026 17 point point NN cord-023095-4dannjjm 4026 18 at at IN cord-023095-4dannjjm 4026 19 which which WDT cord-023095-4dannjjm 4026 20 to to TO cord-023095-4dannjjm 4026 21 initiate initiate VB cord-023095-4dannjjm 4026 22 anti anti JJ cord-023095-4dannjjm 4026 23 - - JJ cord-023095-4dannjjm 4026 24 thrombotic thrombotic JJ cord-023095-4dannjjm 4026 25 therapy therapy NN cord-023095-4dannjjm 4026 26 . . . cord-023095-4dannjjm 4027 1 Cystinuria Cystinuria NNP cord-023095-4dannjjm 4027 2 is be VBZ cord-023095-4dannjjm 4027 3 a a DT cord-023095-4dannjjm 4027 4 hereditary hereditary JJ cord-023095-4dannjjm 4027 5 renal renal JJ cord-023095-4dannjjm 4027 6 tubular tubular JJ cord-023095-4dannjjm 4027 7 reabsorption reabsorption NN cord-023095-4dannjjm 4027 8 defect defect NN cord-023095-4dannjjm 4027 9 of of IN cord-023095-4dannjjm 4027 10 cystine cystine NN cord-023095-4dannjjm 4027 11 , , , cord-023095-4dannjjm 4027 12 ornithine ornithine NN cord-023095-4dannjjm 4027 13 , , , cord-023095-4dannjjm 4027 14 lysine lysine NN cord-023095-4dannjjm 4027 15 and and CC cord-023095-4dannjjm 4027 16 arginine arginine NN cord-023095-4dannjjm 4027 17 ( ( -LRB- cord-023095-4dannjjm 4027 18 collectively collectively RB cord-023095-4dannjjm 4027 19 , , , cord-023095-4dannjjm 4027 20 COLA COLA NNP cord-023095-4dannjjm 4027 21 ) ) -RRB- cord-023095-4dannjjm 4027 22 . . . cord-023095-4dannjjm 4028 1 The the DT cord-023095-4dannjjm 4028 2 low low JJ cord-023095-4dannjjm 4028 3 solubility solubility NN cord-023095-4dannjjm 4028 4 of of IN cord-023095-4dannjjm 4028 5 cystine cystine NN cord-023095-4dannjjm 4028 6 in in IN cord-023095-4dannjjm 4028 7 acidic acidic JJ cord-023095-4dannjjm 4028 8 urine urine NN cord-023095-4dannjjm 4028 9 predisposes predispose VBZ cord-023095-4dannjjm 4028 10 to to IN cord-023095-4dannjjm 4028 11 the the DT cord-023095-4dannjjm 4028 12 formation formation NN cord-023095-4dannjjm 4028 13 of of IN cord-023095-4dannjjm 4028 14 uroliths uroliths NNP cord-023095-4dannjjm 4028 15 . . . cord-023095-4dannjjm 4029 1 Type type NN cord-023095-4dannjjm 4030 1 I -PRON- PRP cord-023095-4dannjjm 4030 2 cystinuria cystinuria VBP cord-023095-4dannjjm 4030 3 in in IN cord-023095-4dannjjm 4030 4 Newfoundland Newfoundland NNP cord-023095-4dannjjm 4030 5 and and CC cord-023095-4dannjjm 4030 6 Labrador Labrador NNP cord-023095-4dannjjm 4030 7 Retriever Retriever NNP cord-023095-4dannjjm 4030 8 dogs dog NNS cord-023095-4dannjjm 4030 9 is be VBZ cord-023095-4dannjjm 4030 10 an an DT cord-023095-4dannjjm 4030 11 autosomal autosomal JJ cord-023095-4dannjjm 4030 12 recessive recessive JJ cord-023095-4dannjjm 4030 13 trait trait NN cord-023095-4dannjjm 4030 14 caused cause VBN cord-023095-4dannjjm 4030 15 by by IN cord-023095-4dannjjm 4030 16 mutations mutation NNS cord-023095-4dannjjm 4030 17 in in IN cord-023095-4dannjjm 4030 18 the the DT cord-023095-4dannjjm 4030 19 SLC3A1 SLC3A1 NNP cord-023095-4dannjjm 4030 20 gene gene NN cord-023095-4dannjjm 4030 21 , , , cord-023095-4dannjjm 4030 22 whereas whereas IN cord-023095-4dannjjm 4030 23 in in IN cord-023095-4dannjjm 4030 24 other other JJ cord-023095-4dannjjm 4030 25 breeds breed NNS cord-023095-4dannjjm 4030 26 , , , cord-023095-4dannjjm 4030 27 the the DT cord-023095-4dannjjm 4030 28 cause cause NN cord-023095-4dannjjm 4030 29 of of IN cord-023095-4dannjjm 4030 30 cystinuria cystinuria NNS cord-023095-4dannjjm 4030 31 has have VBZ cord-023095-4dannjjm 4030 32 not not RB cord-023095-4dannjjm 4030 33 yet yet RB cord-023095-4dannjjm 4030 34 been be VBN cord-023095-4dannjjm 4030 35 determined determine VBN cord-023095-4dannjjm 4030 36 . . . cord-023095-4dannjjm 4031 1 We -PRON- PRP cord-023095-4dannjjm 4031 2 report report VBP cord-023095-4dannjjm 4031 3 here here RB cord-023095-4dannjjm 4031 4 on on IN cord-023095-4dannjjm 4031 5 the the DT cord-023095-4dannjjm 4031 6 clinical clinical JJ cord-023095-4dannjjm 4031 7 , , , cord-023095-4dannjjm 4031 8 biochemical biochemical JJ cord-023095-4dannjjm 4031 9 and and CC cord-023095-4dannjjm 4031 10 molecular molecular JJ cord-023095-4dannjjm 4031 11 features feature NNS cord-023095-4dannjjm 4031 12 of of IN cord-023095-4dannjjm 4031 13 cystinuria cystinuria NNS cord-023095-4dannjjm 4031 14 in in IN cord-023095-4dannjjm 4031 15 Irish irish JJ cord-023095-4dannjjm 4031 16 Terriers terrier NNS cord-023095-4dannjjm 4031 17 . . . cord-023095-4dannjjm 4032 1 Urine urine NN cord-023095-4dannjjm 4032 2 and and CC cord-023095-4dannjjm 4032 3 EDTA EDTA NNP cord-023095-4dannjjm 4032 4 blood blood NN cord-023095-4dannjjm 4032 5 were be VBD cord-023095-4dannjjm 4032 6 collected collect VBN cord-023095-4dannjjm 4032 7 from from IN cord-023095-4dannjjm 4032 8 222 222 CD cord-023095-4dannjjm 4032 9 Irish irish JJ cord-023095-4dannjjm 4032 10 Terriers Terriers NNPS cord-023095-4dannjjm 4032 11 from from IN cord-023095-4dannjjm 4032 12 Europe Europe NNP cord-023095-4dannjjm 4032 13 and and CC cord-023095-4dannjjm 4032 14 Australia Australia NNP cord-023095-4dannjjm 4032 15 . . . cord-023095-4dannjjm 4033 1 A a DT cord-023095-4dannjjm 4033 2 nitroprusside nitroprusside JJ cord-023095-4dannjjm 4033 3 screening screening NN cord-023095-4dannjjm 4033 4 test test NN cord-023095-4dannjjm 4033 5 was be VBD cord-023095-4dannjjm 4033 6 used use VBN cord-023095-4dannjjm 4033 7 to to TO cord-023095-4dannjjm 4033 8 identify identify VB cord-023095-4dannjjm 4033 9 increased increase VBN cord-023095-4dannjjm 4033 10 cystine cystine NN cord-023095-4dannjjm 4033 11 in in IN cord-023095-4dannjjm 4033 12 urine urine NN cord-023095-4dannjjm 4033 13 . . . cord-023095-4dannjjm 4034 1 Urinary urinary JJ cord-023095-4dannjjm 4034 2 amino amino NN cord-023095-4dannjjm 4034 3 acid acid NN cord-023095-4dannjjm 4034 4 concentrations concentration NNS cord-023095-4dannjjm 4034 5 were be VBD cord-023095-4dannjjm 4034 6 determined determine VBN cord-023095-4dannjjm 4034 7 by by IN cord-023095-4dannjjm 4034 8 high high JJ cord-023095-4dannjjm 4034 9 - - HYPH cord-023095-4dannjjm 4034 10 pressure pressure NN cord-023095-4dannjjm 4034 11 liquid liquid NN cord-023095-4dannjjm 4034 12 chromatography chromatography NN cord-023095-4dannjjm 4034 13 . . . cord-023095-4dannjjm 4035 1 Cystinuric cystinuric JJ cord-023095-4dannjjm 4035 2 dogs dog NNS cord-023095-4dannjjm 4035 3 were be VBD cord-023095-4dannjjm 4035 4 defined define VBN cord-023095-4dannjjm 4035 5 as as IN cord-023095-4dannjjm 4035 6 having have VBG cord-023095-4dannjjm 4035 7 cystine cystine NN cord-023095-4dannjjm 4035 8 calculi calculus NNS cord-023095-4dannjjm 4035 9 , , , cord-023095-4dannjjm 4035 10 a a DT cord-023095-4dannjjm 4035 11 positive positive JJ cord-023095-4dannjjm 4035 12 nitroprusside nitroprusside JJ cord-023095-4dannjjm 4035 13 result result NN cord-023095-4dannjjm 4035 14 , , , cord-023095-4dannjjm 4035 15 urinary urinary JJ cord-023095-4dannjjm 4035 16 cystine cystine NN cord-023095-4dannjjm 4035 17 ( ( -LRB- cord-023095-4dannjjm 4035 18 4 4 CD cord-023095-4dannjjm 4035 19 179 179 CD cord-023095-4dannjjm 4035 20 mmol mmol JJ cord-023095-4dannjjm 4035 21 / / SYM cord-023095-4dannjjm 4035 22 g g NN cord-023095-4dannjjm 4035 23 creatinine creatinine NN cord-023095-4dannjjm 4035 24 ) ) -RRB- cord-023095-4dannjjm 4036 1 and/ and/ NNP cord-023095-4dannjjm 4036 2 or or CC cord-023095-4dannjjm 4036 3 a a DT cord-023095-4dannjjm 4036 4 COLA COLA NNP cord-023095-4dannjjm 4036 5 concentration concentration NN cord-023095-4dannjjm 4036 6 of of IN cord-023095-4dannjjm 4036 7 4 4 CD cord-023095-4dannjjm 4036 8 700 700 CD cord-023095-4dannjjm 4036 9 mmol mmol JJ cord-023095-4dannjjm 4036 10 / / SYM cord-023095-4dannjjm 4036 11 g g NN cord-023095-4dannjjm 4036 12 creatinine creatinine NN cord-023095-4dannjjm 4036 13 . . . cord-023095-4dannjjm 4037 1 All all DT cord-023095-4dannjjm 4037 2 83 83 CD cord-023095-4dannjjm 4037 3 females female NNS cord-023095-4dannjjm 4037 4 tested test VBN cord-023095-4dannjjm 4037 5 nitroprusside nitroprusside RB cord-023095-4dannjjm 4037 6 negative negative JJ cord-023095-4dannjjm 4037 7 and and CC cord-023095-4dannjjm 4037 8 had have VBD cord-023095-4dannjjm 4037 9 normal normal JJ cord-023095-4dannjjm 4037 10 urinary urinary JJ cord-023095-4dannjjm 4037 11 cystine cystine NN cord-023095-4dannjjm 4037 12 ( ( -LRB- cord-023095-4dannjjm 4037 13 o o UH cord-023095-4dannjjm 4037 14 150 150 CD cord-023095-4dannjjm 4037 15 mmol mmol JJ cord-023095-4dannjjm 4037 16 / / SYM cord-023095-4dannjjm 4037 17 g g NN cord-023095-4dannjjm 4037 18 creatinine creatinine NN cord-023095-4dannjjm 4037 19 ) ) -RRB- cord-023095-4dannjjm 4037 20 and and CC cord-023095-4dannjjm 4037 21 COLA COLA NNP cord-023095-4dannjjm 4037 22 ( ( -LRB- cord-023095-4dannjjm 4037 23 o o NN cord-023095-4dannjjm 4037 24 500 500 CD cord-023095-4dannjjm 4037 25 mmol mmol JJ cord-023095-4dannjjm 4037 26 / / SYM cord-023095-4dannjjm 4037 27 g g NN cord-023095-4dannjjm 4037 28 creatinine creatinine NN cord-023095-4dannjjm 4037 29 ) ) -RRB- cord-023095-4dannjjm 4037 30 concentrations concentration NNS cord-023095-4dannjjm 4037 31 . . . cord-023095-4dannjjm 4038 1 The the DT cord-023095-4dannjjm 4038 2 10 10 CD cord-023095-4dannjjm 4038 3 intact intact JJ cord-023095-4dannjjm 4038 4 males male NNS cord-023095-4dannjjm 4038 5 that that WDT cord-023095-4dannjjm 4038 6 formed form VBD cord-023095-4dannjjm 4038 7 calculi calculus NNS cord-023095-4dannjjm 4038 8 as as IN cord-023095-4dannjjm 4038 9 adults adult NNS cord-023095-4dannjjm 4038 10 exhibited exhibit VBD cord-023095-4dannjjm 4038 11 cystine cystine NN cord-023095-4dannjjm 4038 12 concentrations concentration NNS cord-023095-4dannjjm 4038 13 ranging range VBG cord-023095-4dannjjm 4038 14 from from IN cord-023095-4dannjjm 4038 15 323 323 CD cord-023095-4dannjjm 4038 16 - - HYPH cord-023095-4dannjjm 4038 17 1580 1580 CD cord-023095-4dannjjm 4038 18 and and CC cord-023095-4dannjjm 4038 19 COLA COLA NNP cord-023095-4dannjjm 4038 20 from from IN cord-023095-4dannjjm 4038 21 1029 1029 CD cord-023095-4dannjjm 4038 22 - - HYPH cord-023095-4dannjjm 4038 23 4302 4302 CD cord-023095-4dannjjm 4038 24 mmol mmol JJ cord-023095-4dannjjm 4038 25 / / SYM cord-023095-4dannjjm 4038 26 g g NN cord-023095-4dannjjm 4038 27 creatinine creatinine NN cord-023095-4dannjjm 4038 28 . . . cord-023095-4dannjjm 4039 1 An an DT cord-023095-4dannjjm 4039 2 additional additional JJ cord-023095-4dannjjm 4039 3 41 41 CD cord-023095-4dannjjm 4039 4 males male NNS cord-023095-4dannjjm 4039 5 had have VBD cord-023095-4dannjjm 4039 6 similarly similarly RB cord-023095-4dannjjm 4039 7 high high JJ cord-023095-4dannjjm 4039 8 COLA COLA NNP cord-023095-4dannjjm 4039 9 values value NNS cord-023095-4dannjjm 4039 10 with with IN cord-023095-4dannjjm 4039 11 cystine cystine NN cord-023095-4dannjjm 4039 12 levels level NNS cord-023095-4dannjjm 4039 13 from from IN cord-023095-4dannjjm 4039 14 0 0 CD cord-023095-4dannjjm 4039 15 - - HYPH cord-023095-4dannjjm 4039 16 1580 1580 CD cord-023095-4dannjjm 4039 17 mmol mmol NNP cord-023095-4dannjjm 4039 18 / / SYM cord-023095-4dannjjm 4039 19 g g NN cord-023095-4dannjjm 4039 20 creatinine creatinine NN cord-023095-4dannjjm 4039 21 . . . cord-023095-4dannjjm 4040 1 Among among IN cord-023095-4dannjjm 4040 2 the the DT cord-023095-4dannjjm 4040 3 affecteds affecteds NNP cord-023095-4dannjjm 4040 4 tested test VBD cord-023095-4dannjjm 4040 5 , , , cord-023095-4dannjjm 4040 6 75 75 CD cord-023095-4dannjjm 4040 7 % % NN cord-023095-4dannjjm 4040 8 were be VBD cord-023095-4dannjjm 4040 9 nitroprusside nitroprusside RB cord-023095-4dannjjm 4040 10 positive positive JJ cord-023095-4dannjjm 4040 11 . . . cord-023095-4dannjjm 4041 1 The the DT cord-023095-4dannjjm 4041 2 negative negative JJ cord-023095-4dannjjm 4041 3 nitroprusside nitroprusside JJ cord-023095-4dannjjm 4041 4 results result NNS cord-023095-4dannjjm 4041 5 and/or and/or CC cord-023095-4dannjjm 4041 6 low low JJ cord-023095-4dannjjm 4041 7 urinary urinary JJ cord-023095-4dannjjm 4041 8 cystine cystine NN cord-023095-4dannjjm 4041 9 levels level NNS cord-023095-4dannjjm 4041 10 of of IN cord-023095-4dannjjm 4041 11 affecteds affecteds NNPS cord-023095-4dannjjm 4041 12 may may MD cord-023095-4dannjjm 4041 13 be be VB cord-023095-4dannjjm 4041 14 due due JJ cord-023095-4dannjjm 4041 15 to to IN cord-023095-4dannjjm 4041 16 precipitation precipitation NN cord-023095-4dannjjm 4041 17 of of IN cord-023095-4dannjjm 4041 18 cystine cystine NN cord-023095-4dannjjm 4041 19 in in IN cord-023095-4dannjjm 4041 20 acidic acidic JJ cord-023095-4dannjjm 4041 21 urine urine NN cord-023095-4dannjjm 4041 22 . . . cord-023095-4dannjjm 4042 1 Sequencing sequence VBG cord-023095-4dannjjm 4042 2 the the DT cord-023095-4dannjjm 4042 3 coding code VBG cord-023095-4dannjjm 4042 4 regions region NNS cord-023095-4dannjjm 4042 5 of of IN cord-023095-4dannjjm 4042 6 the the DT cord-023095-4dannjjm 4042 7 SLC3A1 SLC3A1 NNP cord-023095-4dannjjm 4042 8 and and CC cord-023095-4dannjjm 4042 9 SLC7A9 SLC7A9 NNP cord-023095-4dannjjm 4042 10 genes gene NNS cord-023095-4dannjjm 4042 11 from from IN cord-023095-4dannjjm 4042 12 EDTA EDTA NNP cord-023095-4dannjjm 4042 13 blood blood NN cord-023095-4dannjjm 4042 14 identified identify VBD cord-023095-4dannjjm 4042 15 no no DT cord-023095-4dannjjm 4042 16 mutations mutation NNS cord-023095-4dannjjm 4042 17 . . . cord-023095-4dannjjm 4043 1 The the DT cord-023095-4dannjjm 4043 2 mode mode NN cord-023095-4dannjjm 4043 3 of of IN cord-023095-4dannjjm 4043 4 inheritance inheritance NN cord-023095-4dannjjm 4043 5 remains remain VBZ cord-023095-4dannjjm 4043 6 undetermined undetermined JJ cord-023095-4dannjjm 4043 7 . . . cord-023095-4dannjjm 4044 1 However however RB cord-023095-4dannjjm 4044 2 , , , cord-023095-4dannjjm 4044 3 castration castration NN cord-023095-4dannjjm 4044 4 appears appear VBZ cord-023095-4dannjjm 4044 5 to to TO cord-023095-4dannjjm 4044 6 lower lower VB cord-023095-4dannjjm 4044 7 the the DT cord-023095-4dannjjm 4044 8 urinary urinary JJ cord-023095-4dannjjm 4044 9 cystine cystine NN cord-023095-4dannjjm 4044 10 and and CC cord-023095-4dannjjm 4044 11 COLA COLA NNP cord-023095-4dannjjm 4044 12 concentrations concentration NNS cord-023095-4dannjjm 4044 13 and and CC cord-023095-4dannjjm 4044 14 to to TO cord-023095-4dannjjm 4044 15 prevent prevent VB cord-023095-4dannjjm 4044 16 cystine cystine NN cord-023095-4dannjjm 4044 17 calculi calculus NNS cord-023095-4dannjjm 4044 18 formation formation NN cord-023095-4dannjjm 4044 19 , , , cord-023095-4dannjjm 4044 20 while while IN cord-023095-4dannjjm 4044 21 diet diet NN cord-023095-4dannjjm 4044 22 changes change NNS cord-023095-4dannjjm 4044 23 have have VBP cord-023095-4dannjjm 4044 24 lesser less JJR cord-023095-4dannjjm 4044 25 effects effect NNS cord-023095-4dannjjm 4044 26 . . . cord-023095-4dannjjm 4045 1 In in IN cord-023095-4dannjjm 4045 2 conclusion conclusion NN cord-023095-4dannjjm 4045 3 , , , cord-023095-4dannjjm 4045 4 non non JJ cord-023095-4dannjjm 4045 5 - - JJ cord-023095-4dannjjm 4045 6 type type NN cord-023095-4dannjjm 4045 7 I -PRON- PRP cord-023095-4dannjjm 4045 8 cystinuria cystinuria VBP cord-023095-4dannjjm 4045 9 in in IN cord-023095-4dannjjm 4045 10 Irish irish JJ cord-023095-4dannjjm 4045 11 Terriers Terriers NNPS cord-023095-4dannjjm 4045 12 ( ( -LRB- cord-023095-4dannjjm 4045 13 and and CC cord-023095-4dannjjm 4045 14 several several JJ cord-023095-4dannjjm 4045 15 other other JJ cord-023095-4dannjjm 4045 16 breeds breed NNS cord-023095-4dannjjm 4045 17 like like IN cord-023095-4dannjjm 4045 18 Mastiffs Mastiffs NNPS cord-023095-4dannjjm 4045 19 and and CC cord-023095-4dannjjm 4045 20 Scottish Scottish NNP cord-023095-4dannjjm 4045 21 Deerhounds Deerhounds NNPS cord-023095-4dannjjm 4045 22 ) ) -RRB- cord-023095-4dannjjm 4045 23 is be VBZ cord-023095-4dannjjm 4045 24 a a DT cord-023095-4dannjjm 4045 25 unique unique JJ cord-023095-4dannjjm 4045 26 form form NN cord-023095-4dannjjm 4045 27 characterized characterize VBN cord-023095-4dannjjm 4045 28 by by IN cord-023095-4dannjjm 4045 29 increased increase VBN cord-023095-4dannjjm 4045 30 aminoaciduria aminoaciduria NN cord-023095-4dannjjm 4045 31 only only RB cord-023095-4dannjjm 4045 32 in in IN cord-023095-4dannjjm 4045 33 males male NNS cord-023095-4dannjjm 4045 34 , , , cord-023095-4dannjjm 4045 35 with with IN cord-023095-4dannjjm 4045 36 lower low JJR cord-023095-4dannjjm 4045 37 cystine cystine NN cord-023095-4dannjjm 4045 38 and and CC cord-023095-4dannjjm 4045 39 COLA COLA NNP cord-023095-4dannjjm 4045 40 excretion excretion NN cord-023095-4dannjjm 4045 41 and and CC cord-023095-4dannjjm 4045 42 fewer few JJR cord-023095-4dannjjm 4045 43 and and CC cord-023095-4dannjjm 4045 44 later later RB cord-023095-4dannjjm 4045 45 urolith urolith NN cord-023095-4dannjjm 4045 46 formation formation NN cord-023095-4dannjjm 4045 47 compared compare VBN cord-023095-4dannjjm 4045 48 to to IN cord-023095-4dannjjm 4045 49 type type NN cord-023095-4dannjjm 4045 50 I -PRON- PRP cord-023095-4dannjjm 4045 51 cystinuria cystinuria NNS cord-023095-4dannjjm 4045 52 . . . cord-023095-4dannjjm 4046 1 Castrating castrate VBG cord-023095-4dannjjm 4046 2 cystinuric cystinuric NN cord-023095-4dannjjm 4046 3 Irish Irish NNP cord-023095-4dannjjm 4046 4 Terriers Terriers NNPS cord-023095-4dannjjm 4046 5 lowers lower VBZ cord-023095-4dannjjm 4046 6 their -PRON- PRP$ cord-023095-4dannjjm 4046 7 cystine cystine NN cord-023095-4dannjjm 4046 8 and and CC cord-023095-4dannjjm 4046 9 COLA COLA NNP cord-023095-4dannjjm 4046 10 excretion excretion NN cord-023095-4dannjjm 4046 11 and and CC cord-023095-4dannjjm 4046 12 thus thus RB cord-023095-4dannjjm 4046 13 their -PRON- PRP$ cord-023095-4dannjjm 4046 14 risk risk NN cord-023095-4dannjjm 4046 15 for for IN cord-023095-4dannjjm 4046 16 calculi calculus NNS cord-023095-4dannjjm 4046 17 formation formation NN cord-023095-4dannjjm 4046 18 . . . cord-023095-4dannjjm 4047 1 Cats cat NNS cord-023095-4dannjjm 4047 2 and and CC cord-023095-4dannjjm 4047 3 dogs dog NNS cord-023095-4dannjjm 4047 4 that that WDT cord-023095-4dannjjm 4047 5 are be VBP cord-023095-4dannjjm 4047 6 diagnosed diagnose VBN cord-023095-4dannjjm 4047 7 with with IN cord-023095-4dannjjm 4047 8 acute acute JJ cord-023095-4dannjjm 4047 9 kidney kidney NN cord-023095-4dannjjm 4047 10 injury injury NN cord-023095-4dannjjm 4047 11 ( ( -LRB- cord-023095-4dannjjm 4047 12 AKI AKI NNP cord-023095-4dannjjm 4047 13 ) ) -RRB- cord-023095-4dannjjm 4047 14 and and CC cord-023095-4dannjjm 4047 15 resultant resultant JJ cord-023095-4dannjjm 4047 16 uremia uremia NN cord-023095-4dannjjm 4047 17 that that WDT cord-023095-4dannjjm 4047 18 is be VBZ cord-023095-4dannjjm 4047 19 not not RB cord-023095-4dannjjm 4047 20 responsive responsive JJ cord-023095-4dannjjm 4047 21 to to IN cord-023095-4dannjjm 4047 22 standard standard JJ cord-023095-4dannjjm 4047 23 medical medical JJ cord-023095-4dannjjm 4047 24 therapy therapy NN cord-023095-4dannjjm 4047 25 are be VBP cord-023095-4dannjjm 4047 26 likely likely JJ cord-023095-4dannjjm 4047 27 to to TO cord-023095-4dannjjm 4047 28 benefit benefit VB cord-023095-4dannjjm 4047 29 from from IN cord-023095-4dannjjm 4047 30 renal renal JJ cord-023095-4dannjjm 4047 31 replacement replacement NN cord-023095-4dannjjm 4047 32 therapies therapy NNS cord-023095-4dannjjm 4047 33 , , , cord-023095-4dannjjm 4047 34 such such JJ cord-023095-4dannjjm 4047 35 as as IN cord-023095-4dannjjm 4047 36 intermittent intermittent JJ cord-023095-4dannjjm 4047 37 hemodialysis hemodialysis NN cord-023095-4dannjjm 4047 38 ( ( -LRB- cord-023095-4dannjjm 4047 39 IHD IHD NNP cord-023095-4dannjjm 4047 40 ) ) -RRB- cord-023095-4dannjjm 4047 41 . . . cord-023095-4dannjjm 4048 1 The the DT cord-023095-4dannjjm 4048 2 purpose purpose NN cord-023095-4dannjjm 4048 3 of of IN cord-023095-4dannjjm 4048 4 this this DT cord-023095-4dannjjm 4048 5 study study NN cord-023095-4dannjjm 4048 6 was be VBD cord-023095-4dannjjm 4048 7 to to TO cord-023095-4dannjjm 4048 8 evaluate evaluate VB cord-023095-4dannjjm 4048 9 the the DT cord-023095-4dannjjm 4048 10 long long JJ cord-023095-4dannjjm 4048 11 - - HYPH cord-023095-4dannjjm 4048 12 term term NN cord-023095-4dannjjm 4048 13 outcome outcome NN cord-023095-4dannjjm 4048 14 of of IN cord-023095-4dannjjm 4048 15 patients patient NNS cord-023095-4dannjjm 4048 16 with with IN cord-023095-4dannjjm 4048 17 AKI AKI NNP cord-023095-4dannjjm 4048 18 treated treat VBN cord-023095-4dannjjm 4048 19 with with IN cord-023095-4dannjjm 4048 20 IHD IHD NNP cord-023095-4dannjjm 4048 21 , , , cord-023095-4dannjjm 4048 22 and and CC cord-023095-4dannjjm 4048 23 to to TO cord-023095-4dannjjm 4048 24 establish establish VB cord-023095-4dannjjm 4048 25 whether whether IN cord-023095-4dannjjm 4048 26 renal renal JJ cord-023095-4dannjjm 4048 27 function function NN cord-023095-4dannjjm 4048 28 , , , cord-023095-4dannjjm 4048 29 as as IN cord-023095-4dannjjm 4048 30 determined determine VBN cord-023095-4dannjjm 4048 31 by by IN cord-023095-4dannjjm 4048 32 serum serum NN cord-023095-4dannjjm 4048 33 or or CC cord-023095-4dannjjm 4048 34 plasma plasma NN cord-023095-4dannjjm 4048 35 creatinine creatinine NN cord-023095-4dannjjm 4048 36 concentrations concentration NNS cord-023095-4dannjjm 4048 37 , , , cord-023095-4dannjjm 4048 38 is be VBZ cord-023095-4dannjjm 4048 39 associated associate VBN cord-023095-4dannjjm 4048 40 with with IN cord-023095-4dannjjm 4048 41 longterm longterm JJ cord-023095-4dannjjm 4048 42 survival survival NN cord-023095-4dannjjm 4048 43 . . . cord-023095-4dannjjm 4049 1 Medical medical JJ cord-023095-4dannjjm 4049 2 records record NNS cord-023095-4dannjjm 4049 3 of of IN cord-023095-4dannjjm 4049 4 20 20 CD cord-023095-4dannjjm 4049 5 cats cat NNS cord-023095-4dannjjm 4049 6 and and CC cord-023095-4dannjjm 4049 7 35 35 CD cord-023095-4dannjjm 4049 8 dogs dog NNS cord-023095-4dannjjm 4049 9 that that WDT cord-023095-4dannjjm 4049 10 were be VBD cord-023095-4dannjjm 4049 11 diagnosed diagnose VBN cord-023095-4dannjjm 4049 12 with with IN cord-023095-4dannjjm 4049 13 AKI AKI NNP cord-023095-4dannjjm 4049 14 , , , cord-023095-4dannjjm 4049 15 treated treat VBN cord-023095-4dannjjm 4049 16 with with IN cord-023095-4dannjjm 4049 17 IHD IHD NNP cord-023095-4dannjjm 4049 18 , , , cord-023095-4dannjjm 4049 19 and and CC cord-023095-4dannjjm 4049 20 survived survive VBD cord-023095-4dannjjm 4049 21 longer long RBR cord-023095-4dannjjm 4049 22 than than IN cord-023095-4dannjjm 4049 23 30 30 CD cord-023095-4dannjjm 4049 24 days day NNS cord-023095-4dannjjm 4049 25 following follow VBG cord-023095-4dannjjm 4049 26 the the DT cord-023095-4dannjjm 4049 27 last last JJ cord-023095-4dannjjm 4049 28 IHD IHD NNP cord-023095-4dannjjm 4049 29 treatment treatment NN cord-023095-4dannjjm 4049 30 were be VBD cord-023095-4dannjjm 4049 31 retrospectively retrospectively RB cord-023095-4dannjjm 4049 32 analyzed analyze VBN cord-023095-4dannjjm 4049 33 . . . cord-023095-4dannjjm 4050 1 Standard standard JJ cord-023095-4dannjjm 4050 2 methods method NNS cord-023095-4dannjjm 4050 3 of of IN cord-023095-4dannjjm 4050 4 survival survival NN cord-023095-4dannjjm 4050 5 analysis analysis NN cord-023095-4dannjjm 4050 6 using use VBG cord-023095-4dannjjm 4050 7 Kaplan Kaplan NNP cord-023095-4dannjjm 4050 8 - - HYPH cord-023095-4dannjjm 4050 9 Meier Meier NNP cord-023095-4dannjjm 4050 10 product product NN cord-023095-4dannjjm 4050 11 limit limit NN cord-023095-4dannjjm 4050 12 curves curve NNS cord-023095-4dannjjm 4050 13 and and CC cord-023095-4dannjjm 4050 14 the the DT cord-023095-4dannjjm 4050 15 log log NN cord-023095-4dannjjm 4050 16 - - HYPH cord-023095-4dannjjm 4050 17 rank rank NN cord-023095-4dannjjm 4050 18 test test NN cord-023095-4dannjjm 4050 19 were be VBD cord-023095-4dannjjm 4050 20 performed perform VBN cord-023095-4dannjjm 4050 21 . . . cord-023095-4dannjjm 4051 1 For for IN cord-023095-4dannjjm 4051 2 all all DT cord-023095-4dannjjm 4051 3 - - HYPH cord-023095-4dannjjm 4051 4 cause cause NN cord-023095-4dannjjm 4051 5 mortality mortality NN cord-023095-4dannjjm 4051 6 , , , cord-023095-4dannjjm 4051 7 the the DT cord-023095-4dannjjm 4051 8 median median JJ cord-023095-4dannjjm 4051 9 survival survival NN cord-023095-4dannjjm 4051 10 time time NN cord-023095-4dannjjm 4051 11 was be VBD cord-023095-4dannjjm 4051 12 1823 1823 CD cord-023095-4dannjjm 4051 13 days day NNS cord-023095-4dannjjm 4052 1 ( ( -LRB- cord-023095-4dannjjm 4052 2 95 95 CD cord-023095-4dannjjm 4052 3 % % NN cord-023095-4dannjjm 4052 4 confidence confidence NN cord-023095-4dannjjm 4052 5 interval interval NN cord-023095-4dannjjm 4052 6 : : : cord-023095-4dannjjm 4052 7 841 841 CD cord-023095-4dannjjm 4052 8 , , , cord-023095-4dannjjm 4052 9 4667 4667 CD cord-023095-4dannjjm 4052 10 ) ) -RRB- cord-023095-4dannjjm 4052 11 for for IN cord-023095-4dannjjm 4052 12 cats cat NNS cord-023095-4dannjjm 4052 13 and and CC cord-023095-4dannjjm 4052 14 1049 1049 CD cord-023095-4dannjjm 4052 15 days day NNS cord-023095-4dannjjm 4052 16 ( ( -LRB- cord-023095-4dannjjm 4052 17 95 95 CD cord-023095-4dannjjm 4052 18 % % NN cord-023095-4dannjjm 4052 19 confidence confidence NN cord-023095-4dannjjm 4052 20 interval interval NN cord-023095-4dannjjm 4052 21 : : : cord-023095-4dannjjm 4052 22 893 893 CD cord-023095-4dannjjm 4052 23 , , , cord-023095-4dannjjm 4052 24 1931 1931 CD cord-023095-4dannjjm 4052 25 ) ) -RRB- cord-023095-4dannjjm 4052 26 for for IN cord-023095-4dannjjm 4052 27 dogs dog NNS cord-023095-4dannjjm 4052 28 . . . cord-023095-4dannjjm 4053 1 When when WRB cord-023095-4dannjjm 4053 2 only only RB cord-023095-4dannjjm 4053 3 renal renal JJ cord-023095-4dannjjm 4053 4 - - HYPH cord-023095-4dannjjm 4053 5 related relate VBN cord-023095-4dannjjm 4053 6 causes cause NNS cord-023095-4dannjjm 4053 7 of of IN cord-023095-4dannjjm 4053 8 death death NN cord-023095-4dannjjm 4053 9 were be VBD cord-023095-4dannjjm 4053 10 taken take VBN cord-023095-4dannjjm 4053 11 into into IN cord-023095-4dannjjm 4053 12 account account NN cord-023095-4dannjjm 4053 13 , , , cord-023095-4dannjjm 4053 14 the the DT cord-023095-4dannjjm 4053 15 median median JJ cord-023095-4dannjjm 4053 16 survival survival NN cord-023095-4dannjjm 4053 17 time time NN cord-023095-4dannjjm 4053 18 was be VBD cord-023095-4dannjjm 4053 19 not not RB cord-023095-4dannjjm 4053 20 reached reach VBN cord-023095-4dannjjm 4053 21 for for IN cord-023095-4dannjjm 4053 22 cats cat NNS cord-023095-4dannjjm 4053 23 or or CC cord-023095-4dannjjm 4053 24 dogs dog NNS cord-023095-4dannjjm 4053 25 . . . cord-023095-4dannjjm 4054 1 Survival survival NN cord-023095-4dannjjm 4054 2 time time NN cord-023095-4dannjjm 4054 3 for for IN cord-023095-4dannjjm 4054 4 all all DT cord-023095-4dannjjm 4054 5 - - HYPH cord-023095-4dannjjm 4054 6 cause cause NN cord-023095-4dannjjm 4054 7 mortality mortality NN cord-023095-4dannjjm 4054 8 was be VBD cord-023095-4dannjjm 4054 9 inversely inversely RB cord-023095-4dannjjm 4054 10 associated associate VBN cord-023095-4dannjjm 4054 11 with with IN cord-023095-4dannjjm 4054 12 the the DT cord-023095-4dannjjm 4054 13 lowest low JJS cord-023095-4dannjjm 4054 14 creatinine creatinine NN cord-023095-4dannjjm 4054 15 concentration concentration NN cord-023095-4dannjjm 4054 16 within within IN cord-023095-4dannjjm 4054 17 the the DT cord-023095-4dannjjm 4054 18 30 30 CD cord-023095-4dannjjm 4054 19 to to TO cord-023095-4dannjjm 4054 20 90 90 CD cord-023095-4dannjjm 4054 21 day day NN cord-023095-4dannjjm 4054 22 period period NN cord-023095-4dannjjm 4054 23 following follow VBG cord-023095-4dannjjm 4054 24 the the DT cord-023095-4dannjjm 4054 25 last last JJ cord-023095-4dannjjm 4054 26 IHD IHD NNP cord-023095-4dannjjm 4054 27 treatment treatment NN cord-023095-4dannjjm 4054 28 ( ( -LRB- cord-023095-4dannjjm 4054 29 p p NN cord-023095-4dannjjm 4054 30 o o NN cord-023095-4dannjjm 4054 31 0.0011 0.0011 CD cord-023095-4dannjjm 4054 32 for for IN cord-023095-4dannjjm 4054 33 cats cat NNS cord-023095-4dannjjm 4054 34 , , , cord-023095-4dannjjm 4054 35 p p NN cord-023095-4dannjjm 4054 36 o o NN cord-023095-4dannjjm 4054 37 0.0104 0.0104 CD cord-023095-4dannjjm 4054 38 for for IN cord-023095-4dannjjm 4054 39 dogs dog NNS cord-023095-4dannjjm 4054 40 ) ) -RRB- cord-023095-4dannjjm 4054 41 . . . cord-023095-4dannjjm 4055 1 This this DT cord-023095-4dannjjm 4055 2 study study NN cord-023095-4dannjjm 4055 3 demonstrates demonstrate VBZ cord-023095-4dannjjm 4055 4 that that IN cord-023095-4dannjjm 4055 5 veterinary veterinary JJ cord-023095-4dannjjm 4055 6 patients patient NNS cord-023095-4dannjjm 4055 7 that that WDT cord-023095-4dannjjm 4055 8 are be VBP cord-023095-4dannjjm 4055 9 diagnosed diagnose VBN cord-023095-4dannjjm 4055 10 with with IN cord-023095-4dannjjm 4055 11 AKI AKI NNP cord-023095-4dannjjm 4055 12 , , , cord-023095-4dannjjm 4055 13 treated treat VBN cord-023095-4dannjjm 4055 14 with with IN cord-023095-4dannjjm 4055 15 IHD IHD NNP cord-023095-4dannjjm 4055 16 , , , cord-023095-4dannjjm 4055 17 and and CC cord-023095-4dannjjm 4055 18 survive survive VB cord-023095-4dannjjm 4055 19 greater great JJR cord-023095-4dannjjm 4055 20 than than IN cord-023095-4dannjjm 4055 21 30 30 CD cord-023095-4dannjjm 4055 22 days day NNS cord-023095-4dannjjm 4055 23 after after IN cord-023095-4dannjjm 4055 24 the the DT cord-023095-4dannjjm 4055 25 last last JJ cord-023095-4dannjjm 4055 26 IHD IHD NNP cord-023095-4dannjjm 4055 27 treatment treatment NN cord-023095-4dannjjm 4055 28 have have VBP cord-023095-4dannjjm 4055 29 a a DT cord-023095-4dannjjm 4055 30 good good JJ cord-023095-4dannjjm 4055 31 longterm longterm JJ cord-023095-4dannjjm 4055 32 prognosis prognosis NN cord-023095-4dannjjm 4055 33 and and CC cord-023095-4dannjjm 4055 34 frequently frequently RB cord-023095-4dannjjm 4055 35 die die VB cord-023095-4dannjjm 4055 36 from from IN cord-023095-4dannjjm 4055 37 causes cause NNS cord-023095-4dannjjm 4055 38 that that WDT cord-023095-4dannjjm 4055 39 are be VBP cord-023095-4dannjjm 4055 40 unrelated unrelated JJ cord-023095-4dannjjm 4055 41 to to IN cord-023095-4dannjjm 4055 42 renal renal JJ cord-023095-4dannjjm 4055 43 impairment impairment NN cord-023095-4dannjjm 4055 44 . . . cord-023095-4dannjjm 4056 1 Renal renal JJ cord-023095-4dannjjm 4056 2 fine fine JJ cord-023095-4dannjjm 4056 3 - - HYPH cord-023095-4dannjjm 4056 4 needle needle NN cord-023095-4dannjjm 4056 5 aspiration aspiration NN cord-023095-4dannjjm 4056 6 ( ( -LRB- cord-023095-4dannjjm 4056 7 R R NNP cord-023095-4dannjjm 4056 8 - - HYPH cord-023095-4dannjjm 4056 9 FNA FNA NNP cord-023095-4dannjjm 4056 10 ) ) -RRB- cord-023095-4dannjjm 4056 11 is be VBZ cord-023095-4dannjjm 4056 12 oftentimes oftentimes RB cord-023095-4dannjjm 4056 13 attempted attempt VBN cord-023095-4dannjjm 4056 14 during during IN cord-023095-4dannjjm 4056 15 evaluation evaluation NN cord-023095-4dannjjm 4056 16 of of IN cord-023095-4dannjjm 4056 17 dogs dog NNS cord-023095-4dannjjm 4056 18 and and CC cord-023095-4dannjjm 4056 19 cats cat NNS cord-023095-4dannjjm 4056 20 with with IN cord-023095-4dannjjm 4056 21 renomegaly renomegaly NNP cord-023095-4dannjjm 4056 22 , , , cord-023095-4dannjjm 4056 23 mass mass NN cord-023095-4dannjjm 4056 24 lesions lesion NNS cord-023095-4dannjjm 4056 25 , , , cord-023095-4dannjjm 4056 26 or or CC cord-023095-4dannjjm 4056 27 suspected suspect VBN cord-023095-4dannjjm 4056 28 infiltrative infiltrative JJ cord-023095-4dannjjm 4056 29 processes process NNS cord-023095-4dannjjm 4056 30 . . . cord-023095-4dannjjm 4057 1 Diagnostic diagnostic JJ cord-023095-4dannjjm 4057 2 utility utility NN cord-023095-4dannjjm 4057 3 of of IN cord-023095-4dannjjm 4057 4 FNA FNA NNP cord-023095-4dannjjm 4057 5 is be VBZ cord-023095-4dannjjm 4057 6 dependent dependent JJ cord-023095-4dannjjm 4057 7 upon upon IN cord-023095-4dannjjm 4057 8 the the DT cord-023095-4dannjjm 4057 9 organ organ NN cord-023095-4dannjjm 4057 10 being be VBG cord-023095-4dannjjm 4057 11 sampled sample VBN cord-023095-4dannjjm 4057 12 ; ; : cord-023095-4dannjjm 4057 13 additionally additionally RB cord-023095-4dannjjm 4057 14 , , , cord-023095-4dannjjm 4057 15 in in IN cord-023095-4dannjjm 4057 16 some some DT cord-023095-4dannjjm 4057 17 organs organ NNS cord-023095-4dannjjm 4057 18 , , , cord-023095-4dannjjm 4057 19 certain certain JJ cord-023095-4dannjjm 4057 20 diagnostic diagnostic JJ cord-023095-4dannjjm 4057 21 imaging imaging NN cord-023095-4dannjjm 4057 22 findings finding NNS cord-023095-4dannjjm 4057 23 are be VBP cord-023095-4dannjjm 4057 24 associated associate VBN cord-023095-4dannjjm 4057 25 with with IN cord-023095-4dannjjm 4057 26 improved improved JJ cord-023095-4dannjjm 4057 27 concordance concordance NN cord-023095-4dannjjm 4057 28 of of IN cord-023095-4dannjjm 4057 29 FNA FNA NNP cord-023095-4dannjjm 4057 30 with with IN cord-023095-4dannjjm 4057 31 final final JJ cord-023095-4dannjjm 4057 32 diagnosis diagnosis NN cord-023095-4dannjjm 4057 33 . . . cord-023095-4dannjjm 4058 1 Objectives objective NNS cord-023095-4dannjjm 4058 2 of of IN cord-023095-4dannjjm 4058 3 this this DT cord-023095-4dannjjm 4058 4 study study NN cord-023095-4dannjjm 4058 5 were be VBD cord-023095-4dannjjm 4058 6 to to TO cord-023095-4dannjjm 4058 7 evaluate evaluate VB cord-023095-4dannjjm 4058 8 the the DT cord-023095-4dannjjm 4058 9 diagnostic diagnostic JJ cord-023095-4dannjjm 4058 10 utility utility NN cord-023095-4dannjjm 4058 11 of of IN cord-023095-4dannjjm 4058 12 R R NNP cord-023095-4dannjjm 4058 13 - - HYPH cord-023095-4dannjjm 4058 14 FNA FNA NNP cord-023095-4dannjjm 4058 15 and and CC cord-023095-4dannjjm 4058 16 determine determine VB cord-023095-4dannjjm 4058 17 whether whether IN cord-023095-4dannjjm 4058 18 concordance concordance NN cord-023095-4dannjjm 4058 19 with with IN cord-023095-4dannjjm 4058 20 final final JJ cord-023095-4dannjjm 4058 21 diagnosis diagnosis NN cord-023095-4dannjjm 4058 22 is be VBZ cord-023095-4dannjjm 4058 23 associated associate VBN cord-023095-4dannjjm 4058 24 with with IN cord-023095-4dannjjm 4058 25 specific specific JJ cord-023095-4dannjjm 4058 26 clinicopathologic clinicopathologic JJ cord-023095-4dannjjm 4058 27 or or CC cord-023095-4dannjjm 4058 28 diagnostic diagnostic JJ cord-023095-4dannjjm 4058 29 imaging imaging NN cord-023095-4dannjjm 4058 30 findings finding NNS cord-023095-4dannjjm 4058 31 . . . cord-023095-4dannjjm 4059 1 We -PRON- PRP cord-023095-4dannjjm 4059 2 hypothesized hypothesize VBD cord-023095-4dannjjm 4059 3 that that IN cord-023095-4dannjjm 4059 4 R R NNP cord-023095-4dannjjm 4059 5 - - HYPH cord-023095-4dannjjm 4059 6 FNA FNA NNP cord-023095-4dannjjm 4059 7 is be VBZ cord-023095-4dannjjm 4059 8 most most RBS cord-023095-4dannjjm 4059 9 useful useful JJ cord-023095-4dannjjm 4059 10 in in IN cord-023095-4dannjjm 4059 11 patients patient NNS cord-023095-4dannjjm 4059 12 with with IN cord-023095-4dannjjm 4059 13 diagnostic diagnostic JJ cord-023095-4dannjjm 4059 14 imaging imaging NN cord-023095-4dannjjm 4059 15 results result NNS cord-023095-4dannjjm 4059 16 suggestive suggestive JJ cord-023095-4dannjjm 4059 17 of of IN cord-023095-4dannjjm 4059 18 renal renal JJ cord-023095-4dannjjm 4059 19 neoplasia neoplasia NNS cord-023095-4dannjjm 4059 20 ( ( -LRB- cord-023095-4dannjjm 4059 21 i.e. i.e. FW cord-023095-4dannjjm 4059 22 masses masse NNS cord-023095-4dannjjm 4059 23 or or CC cord-023095-4dannjjm 4059 24 suspected suspect VBN cord-023095-4dannjjm 4059 25 infiltrative infiltrative JJ cord-023095-4dannjjm 4059 26 processes process NNS cord-023095-4dannjjm 4059 27 ) ) -RRB- cord-023095-4dannjjm 4059 28 . . . cord-023095-4dannjjm 4060 1 Dogs dog NNS cord-023095-4dannjjm 4060 2 and and CC cord-023095-4dannjjm 4060 3 cats cat NNS cord-023095-4dannjjm 4060 4 that that WDT cord-023095-4dannjjm 4060 5 had have VBD cord-023095-4dannjjm 4060 6 undergone undergo VBN cord-023095-4dannjjm 4060 7 R R NNP cord-023095-4dannjjm 4060 8 - - HYPH cord-023095-4dannjjm 4060 9 FNA FNA NNP cord-023095-4dannjjm 4060 10 from from IN cord-023095-4dannjjm 4060 11 Jan Jan NNP cord-023095-4dannjjm 4060 12 1 1 CD cord-023095-4dannjjm 4060 13 , , , cord-023095-4dannjjm 4060 14 1998 1998 CD cord-023095-4dannjjm 4060 15 to to IN cord-023095-4dannjjm 4060 16 Dec Dec NNP cord-023095-4dannjjm 4060 17 31 31 CD cord-023095-4dannjjm 4060 18 , , , cord-023095-4dannjjm 4060 19 2008 2008 CD cord-023095-4dannjjm 4060 20 were be VBD cord-023095-4dannjjm 4060 21 identified identify VBN cord-023095-4dannjjm 4060 22 by by IN cord-023095-4dannjjm 4060 23 database database NN cord-023095-4dannjjm 4060 24 search search NN cord-023095-4dannjjm 4060 25 . . . cord-023095-4dannjjm 4061 1 Patient patient JJ cord-023095-4dannjjm 4061 2 signalment signalment JJ cord-023095-4dannjjm 4061 3 , , , cord-023095-4dannjjm 4061 4 serum serum NN cord-023095-4dannjjm 4061 5 creatinine creatinine NN cord-023095-4dannjjm 4061 6 and and CC cord-023095-4dannjjm 4061 7 blood blood NN cord-023095-4dannjjm 4061 8 urea urea NN cord-023095-4dannjjm 4061 9 nitrogen nitrogen NN cord-023095-4dannjjm 4061 10 concentration concentration NN cord-023095-4dannjjm 4061 11 , , , cord-023095-4dannjjm 4061 12 urine urine NN cord-023095-4dannjjm 4061 13 specific specific JJ cord-023095-4dannjjm 4061 14 gravity gravity NN cord-023095-4dannjjm 4061 15 , , , cord-023095-4dannjjm 4061 16 dipstick dipstick NN cord-023095-4dannjjm 4061 17 protein protein NN cord-023095-4dannjjm 4061 18 , , , cord-023095-4dannjjm 4061 19 R R NNP cord-023095-4dannjjm 4061 20 - - HYPH cord-023095-4dannjjm 4061 21 FNA FNA NNP cord-023095-4dannjjm 4061 22 result result NN cord-023095-4dannjjm 4061 23 , , , cord-023095-4dannjjm 4061 24 and and CC cord-023095-4dannjjm 4061 25 final final JJ cord-023095-4dannjjm 4061 26 diagnosis diagnosis NN cord-023095-4dannjjm 4061 27 were be VBD cord-023095-4dannjjm 4061 28 recorded record VBN cord-023095-4dannjjm 4061 29 . . . cord-023095-4dannjjm 4062 1 Patients patient NNS cord-023095-4dannjjm 4062 2 were be VBD cord-023095-4dannjjm 4062 3 excluded exclude VBN cord-023095-4dannjjm 4062 4 if if IN cord-023095-4dannjjm 4062 5 abdominal abdominal JJ cord-023095-4dannjjm 4062 6 radiographs radiograph NNS cord-023095-4dannjjm 4062 7 or or CC cord-023095-4dannjjm 4062 8 sonographic sonographic JJ cord-023095-4dannjjm 4062 9 images image NNS cord-023095-4dannjjm 4062 10 were be VBD cord-023095-4dannjjm 4062 11 not not RB cord-023095-4dannjjm 4062 12 available available JJ cord-023095-4dannjjm 4062 13 for for IN cord-023095-4dannjjm 4062 14 review review NN cord-023095-4dannjjm 4062 15 , , , cord-023095-4dannjjm 4062 16 or or CC cord-023095-4dannjjm 4062 17 if if IN cord-023095-4dannjjm 4062 18 diagnostic diagnostic JJ cord-023095-4dannjjm 4062 19 test test NN cord-023095-4dannjjm 4062 20 results result NNS cord-023095-4dannjjm 4062 21 were be VBD cord-023095-4dannjjm 4062 22 insufficient insufficient JJ cord-023095-4dannjjm 4062 23 for for IN cord-023095-4dannjjm 4062 24 determination determination NN cord-023095-4dannjjm 4062 25 of of IN cord-023095-4dannjjm 4062 26 final final JJ cord-023095-4dannjjm 4062 27 diagnosis diagnosis NN cord-023095-4dannjjm 4062 28 . . . cord-023095-4dannjjm 4063 1 A a DT cord-023095-4dannjjm 4063 2 single single JJ cord-023095-4dannjjm 4063 3 coauthor coauthor NN cord-023095-4dannjjm 4063 4 blinded blind VBN cord-023095-4dannjjm 4063 5 to to IN cord-023095-4dannjjm 4063 6 final final JJ cord-023095-4dannjjm 4063 7 diagnoses diagnosis NNS cord-023095-4dannjjm 4064 1 interpreted interpret VBD cord-023095-4dannjjm 4064 2 all all DT cord-023095-4dannjjm 4064 3 abdominal abdominal JJ cord-023095-4dannjjm 4064 4 images image NNS cord-023095-4dannjjm 4064 5 using use VBG cord-023095-4dannjjm 4064 6 a a DT cord-023095-4dannjjm 4064 7 pre pre JJ cord-023095-4dannjjm 4064 8 - - JJ cord-023095-4dannjjm 4064 9 set set JJ cord-023095-4dannjjm 4064 10 list list NN cord-023095-4dannjjm 4064 11 of of IN cord-023095-4dannjjm 4064 12 descriptors descriptor NNS cord-023095-4dannjjm 4064 13 and and CC cord-023095-4dannjjm 4064 14 grading grading NN cord-023095-4dannjjm 4064 15 criteria criterion NNS cord-023095-4dannjjm 4064 16 . . . cord-023095-4dannjjm 4065 1 Radiographic radiographic JJ cord-023095-4dannjjm 4065 2 kidney kidney NN cord-023095-4dannjjm 4065 3 shape shape NN cord-023095-4dannjjm 4065 4 , , , cord-023095-4dannjjm 4065 5 margin margin NN cord-023095-4dannjjm 4065 6 distortion distortion NN cord-023095-4dannjjm 4065 7 , , , cord-023095-4dannjjm 4065 8 and and CC cord-023095-4dannjjm 4065 9 ventrodorsal ventrodorsal NN cord-023095-4dannjjm 4065 10 kidney kidney NN cord-023095-4dannjjm 4065 11 - - HYPH cord-023095-4dannjjm 4065 12 to to IN cord-023095-4dannjjm 4065 13 - - HYPH cord-023095-4dannjjm 4065 14 L2 l2 NN cord-023095-4dannjjm 4065 15 ratio ratio NN cord-023095-4dannjjm 4065 16 were be VBD cord-023095-4dannjjm 4065 17 evaluated evaluate VBN cord-023095-4dannjjm 4065 18 . . . cord-023095-4dannjjm 4066 1 Sonographic sonographic JJ cord-023095-4dannjjm 4066 2 kidney kidney NN cord-023095-4dannjjm 4066 3 margin margin NN cord-023095-4dannjjm 4066 4 distortion distortion NN cord-023095-4dannjjm 4066 5 , , , cord-023095-4dannjjm 4066 6 cortical cortical JJ cord-023095-4dannjjm 4066 7 echogenicity echogenicity NN cord-023095-4dannjjm 4066 8 , , , cord-023095-4dannjjm 4066 9 and and CC cord-023095-4dannjjm 4066 10 corticomedullary corticomedullary JJ cord-023095-4dannjjm 4066 11 junction junction NN cord-023095-4dannjjm 4066 12 distinction distinction NN cord-023095-4dannjjm 4066 13 were be VBD cord-023095-4dannjjm 4066 14 described describe VBN cord-023095-4dannjjm 4066 15 , , , cord-023095-4dannjjm 4066 16 and and CC cord-023095-4dannjjm 4066 17 presence presence NN cord-023095-4dannjjm 4066 18 of of IN cord-023095-4dannjjm 4066 19 nodules nodule NNS cord-023095-4dannjjm 4066 20 or or CC cord-023095-4dannjjm 4066 21 masses masse NNS cord-023095-4dannjjm 4066 22 , , , cord-023095-4dannjjm 4066 23 peri peri JJ cord-023095-4dannjjm 4066 24 - - HYPH cord-023095-4dannjjm 4066 25 renal renal JJ cord-023095-4dannjjm 4066 26 effusion effusion NN cord-023095-4dannjjm 4066 27 , , , cord-023095-4dannjjm 4066 28 or or CC cord-023095-4dannjjm 4066 29 a a DT cord-023095-4dannjjm 4066 30 peripheral peripheral JJ cord-023095-4dannjjm 4066 31 sonolucent sonolucent NN cord-023095-4dannjjm 4066 32 rim rim NN cord-023095-4dannjjm 4066 33 was be VBD cord-023095-4dannjjm 4066 34 noted note VBN cord-023095-4dannjjm 4066 35 . . . cord-023095-4dannjjm 4067 1 Concordance Concordance NNP cord-023095-4dannjjm 4067 2 of of IN cord-023095-4dannjjm 4067 3 R R NNP cord-023095-4dannjjm 4067 4 - - HYPH cord-023095-4dannjjm 4067 5 FNA FNA NNP cord-023095-4dannjjm 4067 6 and and CC cord-023095-4dannjjm 4067 7 final final JJ cord-023095-4dannjjm 4067 8 diagnosis diagnosis NN cord-023095-4dannjjm 4067 9 was be VBD cord-023095-4dannjjm 4067 10 determined determine VBN cord-023095-4dannjjm 4067 11 , , , cord-023095-4dannjjm 4067 12 and and CC cord-023095-4dannjjm 4067 13 the the DT cord-023095-4dannjjm 4067 14 chi chi NN cord-023095-4dannjjm 4067 15 - - HYPH cord-023095-4dannjjm 4067 16 squared squared JJ cord-023095-4dannjjm 4067 17 or or CC cord-023095-4dannjjm 4067 18 Fisher Fisher NNP cord-023095-4dannjjm 4067 19 's 's POS cord-023095-4dannjjm 4067 20 exact exact JJ cord-023095-4dannjjm 4067 21 test test NN cord-023095-4dannjjm 4067 22 were be VBD cord-023095-4dannjjm 4067 23 used use VBN cord-023095-4dannjjm 4067 24 to to TO cord-023095-4dannjjm 4067 25 determine determine VB cord-023095-4dannjjm 4067 26 association association NNP cord-023095-4dannjjm 4067 27 of of IN cord-023095-4dannjjm 4067 28 concordance concordance NNP cord-023095-4dannjjm 4067 29 with with IN cord-023095-4dannjjm 4067 30 the the DT cord-023095-4dannjjm 4067 31 above above JJ cord-023095-4dannjjm 4067 32 variables variable NNS cord-023095-4dannjjm 4067 33 ; ; : cord-023095-4dannjjm 4067 34 P p NN cord-023095-4dannjjm 4067 35 o o NN cord-023095-4dannjjm 4067 36 0.05 0.05 CD cord-023095-4dannjjm 4067 37 was be VBD cord-023095-4dannjjm 4067 38 considered consider VBN cord-023095-4dannjjm 4067 39 significant significant JJ cord-023095-4dannjjm 4067 40 . . . cord-023095-4dannjjm 4068 1 37 37 CD cord-023095-4dannjjm 4068 2 dogs dog NNS cord-023095-4dannjjm 4068 3 and and CC cord-023095-4dannjjm 4068 4 41 41 CD cord-023095-4dannjjm 4068 5 cats cat NNS cord-023095-4dannjjm 4068 6 ( ( -LRB- cord-023095-4dannjjm 4068 7 78 78 CD cord-023095-4dannjjm 4068 8 animals animal NNS cord-023095-4dannjjm 4068 9 ) ) -RRB- cord-023095-4dannjjm 4068 10 met meet VBD cord-023095-4dannjjm 4068 11 all all DT cord-023095-4dannjjm 4068 12 inclusion inclusion NN cord-023095-4dannjjm 4068 13 criteria criterion NNS cord-023095-4dannjjm 4068 14 . . . cord-023095-4dannjjm 4069 1 R R NNP cord-023095-4dannjjm 4069 2 - - HYPH cord-023095-4dannjjm 4069 3 FNA FNA NNP cord-023095-4dannjjm 4069 4 results result NNS cord-023095-4dannjjm 4069 5 were be VBD cord-023095-4dannjjm 4069 6 concordant concordant JJ cord-023095-4dannjjm 4069 7 with with IN cord-023095-4dannjjm 4069 8 the the DT cord-023095-4dannjjm 4069 9 final final JJ cord-023095-4dannjjm 4069 10 diagnosis diagnosis NN cord-023095-4dannjjm 4069 11 in in IN cord-023095-4dannjjm 4069 12 43 43 CD cord-023095-4dannjjm 4069 13 ( ( -LRB- cord-023095-4dannjjm 4069 14 55.1 55.1 CD cord-023095-4dannjjm 4069 15 % % NN cord-023095-4dannjjm 4069 16 ) ) -RRB- cord-023095-4dannjjm 4069 17 patients patient NNS cord-023095-4dannjjm 4069 18 , , , cord-023095-4dannjjm 4069 19 discordant discordant JJ cord-023095-4dannjjm 4069 20 in in IN cord-023095-4dannjjm 4069 21 12 12 CD cord-023095-4dannjjm 4069 22 ( ( -LRB- cord-023095-4dannjjm 4069 23 15.4 15.4 CD cord-023095-4dannjjm 4069 24 % % NN cord-023095-4dannjjm 4069 25 ) ) -RRB- cord-023095-4dannjjm 4069 26 patients patient NNS cord-023095-4dannjjm 4069 27 , , , cord-023095-4dannjjm 4069 28 and and CC cord-023095-4dannjjm 4069 29 inadequate inadequate JJ cord-023095-4dannjjm 4069 30 for for IN cord-023095-4dannjjm 4069 31 cytologic cytologic JJ cord-023095-4dannjjm 4069 32 interpretation interpretation NN cord-023095-4dannjjm 4069 33 in in IN cord-023095-4dannjjm 4069 34 23 23 CD cord-023095-4dannjjm 4069 35 ( ( -LRB- cord-023095-4dannjjm 4069 36 29.5 29.5 CD cord-023095-4dannjjm 4069 37 % % NN cord-023095-4dannjjm 4069 38 ) ) -RRB- cord-023095-4dannjjm 4069 39 patients patient NNS cord-023095-4dannjjm 4069 40 . . . cord-023095-4dannjjm 4070 1 Neoplasia Neoplasia NNP cord-023095-4dannjjm 4070 2 or or CC cord-023095-4dannjjm 4070 3 FIP FIP NNP cord-023095-4dannjjm 4070 4 were be VBD cord-023095-4dannjjm 4070 5 the the DT cord-023095-4dannjjm 4070 6 final final JJ cord-023095-4dannjjm 4070 7 diagnoses diagnosis NNS cord-023095-4dannjjm 4070 8 in in IN cord-023095-4dannjjm 4070 9 19 19 CD cord-023095-4dannjjm 4070 10 of of IN cord-023095-4dannjjm 4070 11 43 43 CD cord-023095-4dannjjm 4070 12 ( ( -LRB- cord-023095-4dannjjm 4070 13 44.2 44.2 CD cord-023095-4dannjjm 4070 14 % % NN cord-023095-4dannjjm 4070 15 ) ) -RRB- cord-023095-4dannjjm 4070 16 and and CC cord-023095-4dannjjm 4070 17 3 3 CD cord-023095-4dannjjm 4070 18 of of IN cord-023095-4dannjjm 4070 19 43 43 CD cord-023095-4dannjjm 4070 20 ( ( -LRB- cord-023095-4dannjjm 4070 21 7.0 7.0 CD cord-023095-4dannjjm 4070 22 % % NN cord-023095-4dannjjm 4070 23 ) ) -RRB- cord-023095-4dannjjm 4070 24 patients patient NNS cord-023095-4dannjjm 4070 25 with with IN cord-023095-4dannjjm 4070 26 concordant concordant JJ cord-023095-4dannjjm 4070 27 results result NNS cord-023095-4dannjjm 4070 28 , , , cord-023095-4dannjjm 4070 29 respectively respectively RB cord-023095-4dannjjm 4070 30 . . . cord-023095-4dannjjm 4071 1 Renal renal JJ cord-023095-4dannjjm 4071 2 lymphoma lymphoma NN cord-023095-4dannjjm 4071 3 ( ( -LRB- cord-023095-4dannjjm 4071 4 P p NN cord-023095-4dannjjm 4071 5 5 5 CD cord-023095-4dannjjm 4071 6 0.196 0.196 CD cord-023095-4dannjjm 4071 7 ) ) -RRB- cord-023095-4dannjjm 4071 8 , , , cord-023095-4dannjjm 4071 9 renal renal JJ cord-023095-4dannjjm 4071 10 carcinoma carcinoma NN cord-023095-4dannjjm 4071 11 ( ( -LRB- cord-023095-4dannjjm 4071 12 P p NN cord-023095-4dannjjm 4071 13 5 5 CD cord-023095-4dannjjm 4071 14 0.364 0.364 CD cord-023095-4dannjjm 4071 15 ) ) -RRB- cord-023095-4dannjjm 4071 16 , , , cord-023095-4dannjjm 4071 17 and and CC cord-023095-4dannjjm 4071 18 renal renal JJ cord-023095-4dannjjm 4071 19 neoplasia neoplasia NN cord-023095-4dannjjm 4071 20 in in IN cord-023095-4dannjjm 4071 21 general general JJ cord-023095-4dannjjm 4071 22 ( ( -LRB- cord-023095-4dannjjm 4071 23 P p NN cord-023095-4dannjjm 4071 24 5 5 CD cord-023095-4dannjjm 4071 25 0.451 0.451 CD cord-023095-4dannjjm 4071 26 ) ) -RRB- cord-023095-4dannjjm 4071 27 were be VBD cord-023095-4dannjjm 4071 28 not not RB cord-023095-4dannjjm 4071 29 associated associate VBN cord-023095-4dannjjm 4071 30 with with IN cord-023095-4dannjjm 4071 31 a a DT cord-023095-4dannjjm 4071 32 higher high JJR cord-023095-4dannjjm 4071 33 likelihood likelihood NN cord-023095-4dannjjm 4071 34 of of IN cord-023095-4dannjjm 4071 35 R R NNP cord-023095-4dannjjm 4071 36 - - HYPH cord-023095-4dannjjm 4071 37 FNA FNA NNP cord-023095-4dannjjm 4071 38 and and CC cord-023095-4dannjjm 4071 39 final final JJ cord-023095-4dannjjm 4071 40 diagnosis diagnosis NN cord-023095-4dannjjm 4071 41 concordance concordance NN cord-023095-4dannjjm 4071 42 . . . cord-023095-4dannjjm 4072 1 There there EX cord-023095-4dannjjm 4072 2 was be VBD cord-023095-4dannjjm 4072 3 no no DT cord-023095-4dannjjm 4072 4 association association NN cord-023095-4dannjjm 4072 5 noted note VBN cord-023095-4dannjjm 4072 6 between between IN cord-023095-4dannjjm 4072 7 likelihood likelihood NN cord-023095-4dannjjm 4072 8 of of IN cord-023095-4dannjjm 4072 9 R R NNP cord-023095-4dannjjm 4072 10 - - HYPH cord-023095-4dannjjm 4072 11 FNA FNA NNP cord-023095-4dannjjm 4072 12 and and CC cord-023095-4dannjjm 4072 13 final final JJ cord-023095-4dannjjm 4072 14 diagnosis diagnosis NN cord-023095-4dannjjm 4072 15 concordance concordance NN cord-023095-4dannjjm 4072 16 when when WRB cord-023095-4dannjjm 4072 17 patients patient NNS cord-023095-4dannjjm 4072 18 were be VBD cord-023095-4dannjjm 4072 19 stratified stratify VBN cord-023095-4dannjjm 4072 20 by by IN cord-023095-4dannjjm 4072 21 species specie NNS cord-023095-4dannjjm 4072 22 , , , cord-023095-4dannjjm 4072 23 serum serum NN cord-023095-4dannjjm 4072 24 creatinine creatinine NN cord-023095-4dannjjm 4072 25 or or CC cord-023095-4dannjjm 4072 26 blood blood NN cord-023095-4dannjjm 4072 27 urea urea NN cord-023095-4dannjjm 4072 28 nitrogen nitrogen NN cord-023095-4dannjjm 4072 29 concentration concentration NN cord-023095-4dannjjm 4072 30 , , , cord-023095-4dannjjm 4072 31 urine urine NN cord-023095-4dannjjm 4072 32 specific specific JJ cord-023095-4dannjjm 4072 33 gravity gravity NN cord-023095-4dannjjm 4072 34 , , , cord-023095-4dannjjm 4072 35 dipstick dipstick NN cord-023095-4dannjjm 4072 36 proteinuria proteinuria NN cord-023095-4dannjjm 4072 37 , , , cord-023095-4dannjjm 4072 38 or or CC cord-023095-4dannjjm 4072 39 any any DT cord-023095-4dannjjm 4072 40 diagnostic diagnostic JJ cord-023095-4dannjjm 4072 41 imaging imaging NN cord-023095-4dannjjm 4072 42 variables variable NNS cord-023095-4dannjjm 4072 43 . . . cord-023095-4dannjjm 4073 1 This this DT cord-023095-4dannjjm 4073 2 study study NN cord-023095-4dannjjm 4073 3 failed fail VBD cord-023095-4dannjjm 4073 4 to to TO cord-023095-4dannjjm 4073 5 identify identify VB cord-023095-4dannjjm 4073 6 concurrent concurrent JJ cord-023095-4dannjjm 4073 7 clinicopathologic clinicopathologic JJ cord-023095-4dannjjm 4073 8 or or CC cord-023095-4dannjjm 4073 9 diagnostic diagnostic JJ cord-023095-4dannjjm 4073 10 imaging imaging NN cord-023095-4dannjjm 4073 11 findings finding NNS cord-023095-4dannjjm 4073 12 that that WDT cord-023095-4dannjjm 4073 13 enhanced enhance VBD cord-023095-4dannjjm 4073 14 the the DT cord-023095-4dannjjm 4073 15 diagnostic diagnostic JJ cord-023095-4dannjjm 4073 16 utility utility NN cord-023095-4dannjjm 4073 17 of of IN cord-023095-4dannjjm 4073 18 R R NNP cord-023095-4dannjjm 4073 19 - - HYPH cord-023095-4dannjjm 4073 20 FNA FNA NNP cord-023095-4dannjjm 4073 21 . . . cord-023095-4dannjjm 4074 1 Future future JJ cord-023095-4dannjjm 4074 2 studies study NNS cord-023095-4dannjjm 4074 3 should should MD cord-023095-4dannjjm 4074 4 use use VB cord-023095-4dannjjm 4074 5 standardized standardized JJ cord-023095-4dannjjm 4074 6 criteria criterion NNS cord-023095-4dannjjm 4074 7 to to TO cord-023095-4dannjjm 4074 8 prospectively prospectively RB cord-023095-4dannjjm 4074 9 identify identify VB cord-023095-4dannjjm 4074 10 patients patient NNS cord-023095-4dannjjm 4074 11 in in IN cord-023095-4dannjjm 4074 12 which which WDT cord-023095-4dannjjm 4074 13 R r NN cord-023095-4dannjjm 4074 14 - - HYPH cord-023095-4dannjjm 4074 15 FNA FNA NNP cord-023095-4dannjjm 4074 16 will will MD cord-023095-4dannjjm 4074 17 be be VB cord-023095-4dannjjm 4074 18 performed perform VBN cord-023095-4dannjjm 4074 19 , , , cord-023095-4dannjjm 4074 20 evaluate evaluate VB cord-023095-4dannjjm 4074 21 additional additional JJ cord-023095-4dannjjm 4074 22 variables variable NNS cord-023095-4dannjjm 4074 23 that that WDT cord-023095-4dannjjm 4074 24 may may MD cord-023095-4dannjjm 4074 25 be be VB cord-023095-4dannjjm 4074 26 associated associate VBN cord-023095-4dannjjm 4074 27 with with IN cord-023095-4dannjjm 4074 28 increased increase VBN cord-023095-4dannjjm 4074 29 R R NNP cord-023095-4dannjjm 4074 30 - - HYPH cord-023095-4dannjjm 4074 31 FNA FNA NNP cord-023095-4dannjjm 4074 32 diagnostic diagnostic JJ cord-023095-4dannjjm 4074 33 utility utility NN cord-023095-4dannjjm 4074 34 , , , cord-023095-4dannjjm 4074 35 and and CC cord-023095-4dannjjm 4074 36 directly directly RB cord-023095-4dannjjm 4074 37 compare compare VB cord-023095-4dannjjm 4074 38 the the DT cord-023095-4dannjjm 4074 39 utility utility NN cord-023095-4dannjjm 4074 40 of of IN cord-023095-4dannjjm 4074 41 R R NNP cord-023095-4dannjjm 4074 42 - - HYPH cord-023095-4dannjjm 4074 43 FNA FNA NNP cord-023095-4dannjjm 4074 44 with with IN cord-023095-4dannjjm 4074 45 that that DT cord-023095-4dannjjm 4074 46 of of IN cord-023095-4dannjjm 4074 47 other other JJ cord-023095-4dannjjm 4074 48 diagnostic diagnostic JJ cord-023095-4dannjjm 4074 49 techniques technique NNS cord-023095-4dannjjm 4074 50 . . . cord-023095-4dannjjm 4075 1 Feline feline JJ cord-023095-4dannjjm 4075 2 lower low JJR cord-023095-4dannjjm 4075 3 urinary urinary JJ cord-023095-4dannjjm 4075 4 tract tract NN cord-023095-4dannjjm 4075 5 disease disease NN cord-023095-4dannjjm 4075 6 ( ( -LRB- cord-023095-4dannjjm 4075 7 FLUTD FLUTD NNP cord-023095-4dannjjm 4075 8 ) ) -RRB- cord-023095-4dannjjm 4075 9 is be VBZ cord-023095-4dannjjm 4075 10 a a DT cord-023095-4dannjjm 4075 11 disease disease NN cord-023095-4dannjjm 4075 12 with with IN cord-023095-4dannjjm 4075 13 increasing increase VBG cord-023095-4dannjjm 4075 14 prevalence prevalence NN cord-023095-4dannjjm 4075 15 in in IN cord-023095-4dannjjm 4075 16 private private JJ cord-023095-4dannjjm 4075 17 practices practice NNS cord-023095-4dannjjm 4075 18 and and CC cord-023095-4dannjjm 4075 19 veterinary veterinary JJ cord-023095-4dannjjm 4075 20 teaching teaching NN cord-023095-4dannjjm 4075 21 hospitals hospital NNS cord-023095-4dannjjm 4075 22 . . . cord-023095-4dannjjm 4076 1 Although although IN cord-023095-4dannjjm 4076 2 several several JJ cord-023095-4dannjjm 4076 3 underlying underlie VBG cord-023095-4dannjjm 4076 4 causes cause NNS cord-023095-4dannjjm 4076 5 can can MD cord-023095-4dannjjm 4076 6 cause cause VB cord-023095-4dannjjm 4076 7 the the DT cord-023095-4dannjjm 4076 8 obstructive obstructive JJ cord-023095-4dannjjm 4076 9 form form NN cord-023095-4dannjjm 4076 10 in in IN cord-023095-4dannjjm 4076 11 male male JJ cord-023095-4dannjjm 4076 12 cats cat NNS cord-023095-4dannjjm 4076 13 , , , cord-023095-4dannjjm 4076 14 the the DT cord-023095-4dannjjm 4076 15 idiopathic idiopathic JJ cord-023095-4dannjjm 4076 16 form form NN cord-023095-4dannjjm 4076 17 ( ( -LRB- cord-023095-4dannjjm 4076 18 feline feline JJ cord-023095-4dannjjm 4076 19 interstitial interstitial JJ cord-023095-4dannjjm 4076 20 cystitis cystitis NN cord-023095-4dannjjm 4076 21 ) ) -RRB- cord-023095-4dannjjm 4076 22 often often RB cord-023095-4dannjjm 4076 23 is be VBZ cord-023095-4dannjjm 4076 24 diagnosed diagnose VBN cord-023095-4dannjjm 4076 25 as as IN cord-023095-4dannjjm 4076 26 underlying underlying JJ cord-023095-4dannjjm 4076 27 reason reason NN cord-023095-4dannjjm 4076 28 in in IN cord-023095-4dannjjm 4076 29 cats cat NNS cord-023095-4dannjjm 4077 1 o o LS cord-023095-4dannjjm 4077 2 10 10 CD cord-023095-4dannjjm 4077 3 years year NNS cord-023095-4dannjjm 4077 4 . . . cord-023095-4dannjjm 4078 1 The the DT cord-023095-4dannjjm 4078 2 goal goal NN cord-023095-4dannjjm 4078 3 of of IN cord-023095-4dannjjm 4078 4 this this DT cord-023095-4dannjjm 4078 5 retrospective retrospective JJ cord-023095-4dannjjm 4078 6 study study NN cord-023095-4dannjjm 4078 7 was be VBD cord-023095-4dannjjm 4078 8 to to TO cord-023095-4dannjjm 4078 9 identify identify VB cord-023095-4dannjjm 4078 10 possible possible JJ cord-023095-4dannjjm 4078 11 predisposing predisposing JJ cord-023095-4dannjjm 4078 12 factors factor NNS cord-023095-4dannjjm 4078 13 in in IN cord-023095-4dannjjm 4078 14 order order NN cord-023095-4dannjjm 4078 15 to to TO cord-023095-4dannjjm 4078 16 optimize optimize VB cord-023095-4dannjjm 4078 17 the the DT cord-023095-4dannjjm 4078 18 therapy therapy NN cord-023095-4dannjjm 4078 19 of of IN cord-023095-4dannjjm 4078 20 these these DT cord-023095-4dannjjm 4078 21 patients patient NNS cord-023095-4dannjjm 4078 22 . . . cord-023095-4dannjjm 4079 1 As as IN cord-023095-4dannjjm 4079 2 a a DT cord-023095-4dannjjm 4079 3 study study NN cord-023095-4dannjjm 4079 4 group group NN cord-023095-4dannjjm 4079 5 , , , cord-023095-4dannjjm 4079 6 40 40 CD cord-023095-4dannjjm 4079 7 cats cat NNS cord-023095-4dannjjm 4079 8 hospitalized hospitalize VBN cord-023095-4dannjjm 4079 9 with with IN cord-023095-4dannjjm 4079 10 obstructive obstructive JJ cord-023095-4dannjjm 4079 11 FLUTD FLUTD NNP cord-023095-4dannjjm 4079 12 at at IN cord-023095-4dannjjm 4079 13 the the DT cord-023095-4dannjjm 4079 14 Veterinary Veterinary NNP cord-023095-4dannjjm 4079 15 University University NNP cord-023095-4dannjjm 4079 16 of of IN cord-023095-4dannjjm 4079 17 Vienna Vienna NNP cord-023095-4dannjjm 4079 18 were be VBD cord-023095-4dannjjm 4079 19 examined examine VBN cord-023095-4dannjjm 4079 20 during during IN cord-023095-4dannjjm 4079 21 a a DT cord-023095-4dannjjm 4079 22 2 2 CD cord-023095-4dannjjm 4079 23 year year NN cord-023095-4dannjjm 4079 24 period period NN cord-023095-4dannjjm 4079 25 ( ( -LRB- cord-023095-4dannjjm 4079 26 2008 2008 CD cord-023095-4dannjjm 4079 27 ) ) -RRB- cord-023095-4dannjjm 4079 28 ( ( -LRB- cord-023095-4dannjjm 4079 29 2009 2009 CD cord-023095-4dannjjm 4079 30 ) ) -RRB- cord-023095-4dannjjm 4079 31 ( ( -LRB- cord-023095-4dannjjm 4079 32 2010 2010 CD cord-023095-4dannjjm 4079 33 ) ) -RRB- cord-023095-4dannjjm 4079 34 . . . cord-023095-4dannjjm 4080 1 As as IN cord-023095-4dannjjm 4080 2 a a DT cord-023095-4dannjjm 4080 3 control control NN cord-023095-4dannjjm 4080 4 group group NN cord-023095-4dannjjm 4080 5 40 40 CD cord-023095-4dannjjm 4080 6 cats cat NNS cord-023095-4dannjjm 4080 7 presented present VBN cord-023095-4dannjjm 4080 8 for for IN cord-023095-4dannjjm 4080 9 other other JJ cord-023095-4dannjjm 4080 10 reasons reason NNS cord-023095-4dannjjm 4080 11 were be VBD cord-023095-4dannjjm 4080 12 randomly randomly RB cord-023095-4dannjjm 4080 13 chosen choose VBN cord-023095-4dannjjm 4080 14 during during IN cord-023095-4dannjjm 4080 15 the the DT cord-023095-4dannjjm 4080 16 same same JJ cord-023095-4dannjjm 4080 17 time time NN cord-023095-4dannjjm 4080 18 period period NN cord-023095-4dannjjm 4080 19 . . . cord-023095-4dannjjm 4081 1 The the DT cord-023095-4dannjjm 4081 2 data datum NNS cord-023095-4dannjjm 4081 3 were be VBD cord-023095-4dannjjm 4081 4 examined examine VBN cord-023095-4dannjjm 4081 5 concerning concern VBG cord-023095-4dannjjm 4081 6 the the DT cord-023095-4dannjjm 4081 7 signalment signalment NN cord-023095-4dannjjm 4081 8 and and CC cord-023095-4dannjjm 4081 9 history history NN cord-023095-4dannjjm 4081 10 . . . cord-023095-4dannjjm 4082 1 Furthermore furthermore RB cord-023095-4dannjjm 4082 2 , , , cord-023095-4dannjjm 4082 3 the the DT cord-023095-4dannjjm 4082 4 long long JJ cord-023095-4dannjjm 4082 5 - - HYPH cord-023095-4dannjjm 4082 6 term term NN cord-023095-4dannjjm 4082 7 outcome outcome NN cord-023095-4dannjjm 4082 8 was be VBD cord-023095-4dannjjm 4082 9 evaluated evaluate VBN cord-023095-4dannjjm 4082 10 with with IN cord-023095-4dannjjm 4082 11 a a DT cord-023095-4dannjjm 4082 12 questionnaire questionnaire NN cord-023095-4dannjjm 4082 13 . . . cord-023095-4dannjjm 4083 1 Based base VBN cord-023095-4dannjjm 4083 2 on on IN cord-023095-4dannjjm 4083 3 assumptions assumption NNS cord-023095-4dannjjm 4083 4 a a DT cord-023095-4dannjjm 4083 5 student student NN cord-023095-4dannjjm 4083 6 's 's POS cord-023095-4dannjjm 4083 7 t t NN cord-023095-4dannjjm 4083 8 - - HYPH cord-023095-4dannjjm 4083 9 test test NN cord-023095-4dannjjm 4083 10 or or CC cord-023095-4dannjjm 4083 11 a a DT cord-023095-4dannjjm 4083 12 chi chi JJ cord-023095-4dannjjm 4083 13 - - JJ cord-023095-4dannjjm 4083 14 square square JJ cord-023095-4dannjjm 4083 15 test test NN cord-023095-4dannjjm 4083 16 was be VBD cord-023095-4dannjjm 4083 17 used use VBN cord-023095-4dannjjm 4083 18 . . . cord-023095-4dannjjm 4084 1 There there EX cord-023095-4dannjjm 4084 2 were be VBD cord-023095-4dannjjm 4084 3 no no DT cord-023095-4dannjjm 4084 4 significant significant JJ cord-023095-4dannjjm 4084 5 differences difference NNS cord-023095-4dannjjm 4084 6 in in IN cord-023095-4dannjjm 4084 7 age age NN cord-023095-4dannjjm 4084 8 and and CC cord-023095-4dannjjm 4084 9 breed breed NN cord-023095-4dannjjm 4084 10 . . . cord-023095-4dannjjm 4085 1 The the DT cord-023095-4dannjjm 4085 2 body body NN cord-023095-4dannjjm 4085 3 weight weight NN cord-023095-4dannjjm 4085 4 was be VBD cord-023095-4dannjjm 4085 5 significant significant JJ cord-023095-4dannjjm 4085 6 higher higher RBR cord-023095-4dannjjm 4085 7 in in IN cord-023095-4dannjjm 4085 8 the the DT cord-023095-4dannjjm 4085 9 FLUTD FLUTD NNP cord-023095-4dannjjm 4085 10 group group NN cord-023095-4dannjjm 4085 11 than than IN cord-023095-4dannjjm 4085 12 in in IN cord-023095-4dannjjm 4085 13 the the DT cord-023095-4dannjjm 4085 14 control control NN cord-023095-4dannjjm 4085 15 group group NN cord-023095-4dannjjm 4085 16 ( ( -LRB- cord-023095-4dannjjm 4085 17 p p NN cord-023095-4dannjjm 4085 18 o o NN cord-023095-4dannjjm 4085 19 0.01 0.01 CD cord-023095-4dannjjm 4085 20 ) ) -RRB- cord-023095-4dannjjm 4085 21 . . . cord-023095-4dannjjm 4086 1 We -PRON- PRP cord-023095-4dannjjm 4086 2 could could MD cord-023095-4dannjjm 4086 3 observe observe VB cord-023095-4dannjjm 4086 4 a a DT cord-023095-4dannjjm 4086 5 significant significant JJ cord-023095-4dannjjm 4086 6 risk risk NN cord-023095-4dannjjm 4086 7 for for IN cord-023095-4dannjjm 4086 8 the the DT cord-023095-4dannjjm 4086 9 disease disease NN cord-023095-4dannjjm 4086 10 of of IN cord-023095-4dannjjm 4086 11 a a DT cord-023095-4dannjjm 4086 12 weight weight NN cord-023095-4dannjjm 4086 13 of of IN cord-023095-4dannjjm 4086 14 4 4 CD cord-023095-4dannjjm 4086 15 5 5 CD cord-023095-4dannjjm 4086 16 kg kg NNS cord-023095-4dannjjm 4086 17 ( ( -LRB- cord-023095-4dannjjm 4086 18 p p NN cord-023095-4dannjjm 4086 19 o o NN cord-023095-4dannjjm 4086 20 0.01 0.01 CD cord-023095-4dannjjm 4086 21 ) ) -RRB- cord-023095-4dannjjm 4086 22 . . . cord-023095-4dannjjm 4087 1 There there EX cord-023095-4dannjjm 4087 2 were be VBD cord-023095-4dannjjm 4087 3 significant significant JJ cord-023095-4dannjjm 4087 4 less less JJR cord-023095-4dannjjm 4087 5 cat cat NN cord-023095-4dannjjm 4087 6 toilets toilet NNS cord-023095-4dannjjm 4087 7 in in IN cord-023095-4dannjjm 4087 8 the the DT cord-023095-4dannjjm 4087 9 FLUTD FLUTD NNP cord-023095-4dannjjm 4087 10 group group NN cord-023095-4dannjjm 4087 11 compared compare VBN cord-023095-4dannjjm 4087 12 to to IN cord-023095-4dannjjm 4087 13 the the DT cord-023095-4dannjjm 4087 14 control control NN cord-023095-4dannjjm 4087 15 group group NN cord-023095-4dannjjm 4087 16 ( ( -LRB- cord-023095-4dannjjm 4087 17 p p NN cord-023095-4dannjjm 4087 18 o o NN cord-023095-4dannjjm 4087 19 0.05 0.05 CD cord-023095-4dannjjm 4087 20 ) ) -RRB- cord-023095-4dannjjm 4087 21 . . . cord-023095-4dannjjm 4088 1 Furthermore furthermore RB cord-023095-4dannjjm 4088 2 we -PRON- PRP cord-023095-4dannjjm 4088 3 could could MD cord-023095-4dannjjm 4088 4 observe observe VB cord-023095-4dannjjm 4088 5 that that IN cord-023095-4dannjjm 4088 6 in in IN cord-023095-4dannjjm 4088 7 the the DT cord-023095-4dannjjm 4088 8 households household NNS cord-023095-4dannjjm 4088 9 of of IN cord-023095-4dannjjm 4088 10 FLUTD FLUTD NNP cord-023095-4dannjjm 4088 11 cats cat NNS cord-023095-4dannjjm 4088 12 there there EX cord-023095-4dannjjm 4088 13 was be VBD cord-023095-4dannjjm 4088 14 significant significant JJ cord-023095-4dannjjm 4088 15 less less JJR cord-023095-4dannjjm 4088 16 than than IN cord-023095-4dannjjm 4088 17 one one CD cord-023095-4dannjjm 4088 18 toilet toilet NN cord-023095-4dannjjm 4088 19 per per IN cord-023095-4dannjjm 4088 20 cat cat NN cord-023095-4dannjjm 4088 21 ( ( -LRB- cord-023095-4dannjjm 4088 22 p p NN cord-023095-4dannjjm 4088 23 o o NN cord-023095-4dannjjm 4088 24 0.01 0.01 CD cord-023095-4dannjjm 4088 25 ) ) -RRB- cord-023095-4dannjjm 4088 26 and and CC cord-023095-4dannjjm 4088 27 more more JJR cord-023095-4dannjjm 4088 28 cats cat NNS cord-023095-4dannjjm 4088 29 diseased disease VBN cord-023095-4dannjjm 4088 30 on on IN cord-023095-4dannjjm 4088 31 FLUTD FLUTD NNP cord-023095-4dannjjm 4088 32 lived live VBD cord-023095-4dannjjm 4088 33 strictly strictly RB cord-023095-4dannjjm 4088 34 indoor indoor JJ cord-023095-4dannjjm 4088 35 than than IN cord-023095-4dannjjm 4088 36 outdoor outdoor JJ cord-023095-4dannjjm 4088 37 ( ( -LRB- cord-023095-4dannjjm 4088 38 p p NN cord-023095-4dannjjm 4088 39 5 5 CD cord-023095-4dannjjm 4088 40 0.05).There 0.05).there CD cord-023095-4dannjjm 4088 41 were be VBD cord-023095-4dannjjm 4088 42 no no DT cord-023095-4dannjjm 4088 43 significant significant JJ cord-023095-4dannjjm 4088 44 differences difference NNS cord-023095-4dannjjm 4088 45 at at IN cord-023095-4dannjjm 4088 46 the the DT cord-023095-4dannjjm 4088 47 time time NN cord-023095-4dannjjm 4088 48 of of IN cord-023095-4dannjjm 4088 49 hospitalization hospitalization NN cord-023095-4dannjjm 4088 50 in in IN cord-023095-4dannjjm 4088 51 age age NN cord-023095-4dannjjm 4088 52 , , , cord-023095-4dannjjm 4088 53 breed breed NN cord-023095-4dannjjm 4088 54 , , , cord-023095-4dannjjm 4088 55 number number NN cord-023095-4dannjjm 4088 56 of of IN cord-023095-4dannjjm 4088 57 cats cat NNS cord-023095-4dannjjm 4088 58 per per IN cord-023095-4dannjjm 4088 59 household household NN cord-023095-4dannjjm 4088 60 or or CC cord-023095-4dannjjm 4088 61 season season NN cord-023095-4dannjjm 4088 62 of of IN cord-023095-4dannjjm 4088 63 the the DT cord-023095-4dannjjm 4088 64 year year NN cord-023095-4dannjjm 4088 65 between between IN cord-023095-4dannjjm 4088 66 the the DT cord-023095-4dannjjm 4088 67 two two CD cord-023095-4dannjjm 4088 68 groups group NNS cord-023095-4dannjjm 4088 69 . . . cord-023095-4dannjjm 4089 1 In in IN cord-023095-4dannjjm 4089 2 summary summary NN cord-023095-4dannjjm 4089 3 , , , cord-023095-4dannjjm 4089 4 we -PRON- PRP cord-023095-4dannjjm 4089 5 could could MD cord-023095-4dannjjm 4089 6 observe observe VB cord-023095-4dannjjm 4089 7 that that IN cord-023095-4dannjjm 4089 8 cats cat NNS cord-023095-4dannjjm 4089 9 over over IN cord-023095-4dannjjm 4089 10 5 5 CD cord-023095-4dannjjm 4089 11 kg kg NN cord-023095-4dannjjm 4089 12 body body NN cord-023095-4dannjjm 4089 13 weight weight NN cord-023095-4dannjjm 4089 14 kept keep VBD cord-023095-4dannjjm 4089 15 indoor indoor JJ cord-023095-4dannjjm 4089 16 with with IN cord-023095-4dannjjm 4090 1 less less JJR cord-023095-4dannjjm 4090 2 than than IN cord-023095-4dannjjm 4090 3 one one CD cord-023095-4dannjjm 4090 4 toilet toilet NN cord-023095-4dannjjm 4090 5 per per IN cord-023095-4dannjjm 4090 6 cat cat NN cord-023095-4dannjjm 4090 7 have have VBP cord-023095-4dannjjm 4090 8 a a DT cord-023095-4dannjjm 4090 9 significant significant JJ cord-023095-4dannjjm 4090 10 higher high JJR cord-023095-4dannjjm 4090 11 possibility possibility NN cord-023095-4dannjjm 4090 12 to to TO cord-023095-4dannjjm 4090 13 be be VB cord-023095-4dannjjm 4090 14 affected affect VBN cord-023095-4dannjjm 4090 15 by by IN cord-023095-4dannjjm 4090 16 obstructive obstructive JJ cord-023095-4dannjjm 4090 17 FLUTD FLUTD NNP cord-023095-4dannjjm 4090 18 . . . cord-023095-4dannjjm 4091 1 Further further JJ cord-023095-4dannjjm 4091 2 studies study NNS cord-023095-4dannjjm 4091 3 with with IN cord-023095-4dannjjm 4091 4 an an DT cord-023095-4dannjjm 4091 5 extensive extensive JJ cord-023095-4dannjjm 4091 6 history history NN cord-023095-4dannjjm 4091 7 of of IN cord-023095-4dannjjm 4091 8 animal animal NN cord-023095-4dannjjm 4091 9 husbandry husbandry NN cord-023095-4dannjjm 4091 10 are be VBP cord-023095-4dannjjm 4091 11 needed need VBN cord-023095-4dannjjm 4091 12 to to TO cord-023095-4dannjjm 4091 13 identify identify VB cord-023095-4dannjjm 4091 14 risks risk NNS cord-023095-4dannjjm 4091 15 predispoing predispoe VBG cord-023095-4dannjjm 4091 16 cats cat NNS cord-023095-4dannjjm 4091 17 to to IN cord-023095-4dannjjm 4091 18 this this DT cord-023095-4dannjjm 4091 19 frequent frequent JJ cord-023095-4dannjjm 4091 20 and and CC cord-023095-4dannjjm 4091 21 cost cost NN cord-023095-4dannjjm 4091 22 - - HYPH cord-023095-4dannjjm 4091 23 intensive intensive JJ cord-023095-4dannjjm 4091 24 disease disease NN cord-023095-4dannjjm 4091 25 . . . cord-023095-4dannjjm 4092 1 Although although IN cord-023095-4dannjjm 4092 2 purine purine NN cord-023095-4dannjjm 4092 3 uroliths uroliths NNP cord-023095-4dannjjm 4092 4 ( ( -LRB- cord-023095-4dannjjm 4092 5 ammonium ammonium NN cord-023095-4dannjjm 4092 6 urate urate NN cord-023095-4dannjjm 4092 7 , , , cord-023095-4dannjjm 4092 8 sodium sodium NN cord-023095-4dannjjm 4092 9 urate urate NN cord-023095-4dannjjm 4092 10 , , , cord-023095-4dannjjm 4092 11 xanthine xanthine NN cord-023095-4dannjjm 4092 12 , , , cord-023095-4dannjjm 4092 13 uric uric NN cord-023095-4dannjjm 4092 14 acid acid NN cord-023095-4dannjjm 4092 15 , , , cord-023095-4dannjjm 4092 16 etc etc FW cord-023095-4dannjjm 4092 17 . . . cord-023095-4dannjjm 4092 18 ) ) -RRB- cord-023095-4dannjjm 4092 19 represent represent VB cord-023095-4dannjjm 4092 20 the the DT cord-023095-4dannjjm 4092 21 third third JJ cord-023095-4dannjjm 4092 22 most most RBS cord-023095-4dannjjm 4092 23 common common JJ cord-023095-4dannjjm 4092 24 stone stone NN cord-023095-4dannjjm 4092 25 type type NN cord-023095-4dannjjm 4092 26 in in IN cord-023095-4dannjjm 4092 27 cats cat NNS cord-023095-4dannjjm 4092 28 , , , cord-023095-4dannjjm 4092 29 purine purine NN cord-023095-4dannjjm 4092 30 uroliths urolith NNS cord-023095-4dannjjm 4092 31 have have VBP cord-023095-4dannjjm 4092 32 the the DT cord-023095-4dannjjm 4092 33 highest high JJS cord-023095-4dannjjm 4092 34 rate rate NN cord-023095-4dannjjm 4092 35 of of IN cord-023095-4dannjjm 4092 36 recurrence recurrence NN cord-023095-4dannjjm 4092 37 ( ( -LRB- cord-023095-4dannjjm 4092 38 13 13 CD cord-023095-4dannjjm 4092 39 % % NN cord-023095-4dannjjm 4092 40 in in IN cord-023095-4dannjjm 4092 41 22 22 CD cord-023095-4dannjjm 4092 42 months month NNS cord-023095-4dannjjm 4092 43 ) ) -RRB- cord-023095-4dannjjm 4092 44 . . . cord-023095-4dannjjm 4093 1 In in IN cord-023095-4dannjjm 4093 2 dogs dog NNS cord-023095-4dannjjm 4093 3 , , , cord-023095-4dannjjm 4093 4 mutation mutation NN cord-023095-4dannjjm 4093 5 of of IN cord-023095-4dannjjm 4093 6 the the DT cord-023095-4dannjjm 4093 7 urate urate NN cord-023095-4dannjjm 4093 8 transporter transporter NN cord-023095-4dannjjm 4093 9 ( ( -LRB- cord-023095-4dannjjm 4093 10 SLC2A9 SLC2A9 NNP cord-023095-4dannjjm 4093 11 ) ) -RRB- cord-023095-4dannjjm 4093 12 and and CC cord-023095-4dannjjm 4093 13 portovascular portovascular NNP cord-023095-4dannjjm 4093 14 anomalies anomaly NNS cord-023095-4dannjjm 4093 15 are be VBP cord-023095-4dannjjm 4093 16 common common JJ cord-023095-4dannjjm 4093 17 risk risk NN cord-023095-4dannjjm 4093 18 factors factor NNS cord-023095-4dannjjm 4093 19 . . . cord-023095-4dannjjm 4094 1 However however RB cord-023095-4dannjjm 4094 2 the the DT cord-023095-4dannjjm 4094 3 underlying underlie VBG cord-023095-4dannjjm 4094 4 cause(s cause(s NNP cord-023095-4dannjjm 4094 5 ) ) -RRB- cord-023095-4dannjjm 4094 6 for for IN cord-023095-4dannjjm 4094 7 purine purine NNP cord-023095-4dannjjm 4094 8 urolith urolith NNP cord-023095-4dannjjm 4094 9 formation formation NN cord-023095-4dannjjm 4094 10 in in IN cord-023095-4dannjjm 4094 11 cats cat NNS cord-023095-4dannjjm 4094 12 is be VBZ cord-023095-4dannjjm 4094 13 unknown unknown JJ cord-023095-4dannjjm 4094 14 . . . cord-023095-4dannjjm 4095 1 The the DT cord-023095-4dannjjm 4095 2 purpose purpose NN cord-023095-4dannjjm 4095 3 of of IN cord-023095-4dannjjm 4095 4 this this DT cord-023095-4dannjjm 4095 5 study study NN cord-023095-4dannjjm 4095 6 was be VBD cord-023095-4dannjjm 4095 7 to to TO cord-023095-4dannjjm 4095 8 test test VB cord-023095-4dannjjm 4095 9 the the DT cord-023095-4dannjjm 4095 10 hypothesis hypothesis NN cord-023095-4dannjjm 4095 11 that that IN cord-023095-4dannjjm 4095 12 hyperuricosuria hyperuricosuria NNP cord-023095-4dannjjm 4095 13 without without IN cord-023095-4dannjjm 4095 14 alterations alteration NNS cord-023095-4dannjjm 4095 15 in in IN cord-023095-4dannjjm 4095 16 liver liver NN cord-023095-4dannjjm 4095 17 function function NN cord-023095-4dannjjm 4095 18 is be VBZ cord-023095-4dannjjm 4095 19 common common JJ cord-023095-4dannjjm 4095 20 in in IN cord-023095-4dannjjm 4095 21 cats cat NNS cord-023095-4dannjjm 4095 22 with with IN cord-023095-4dannjjm 4095 23 urate urate NN cord-023095-4dannjjm 4095 24 uroliths uroliths NNP cord-023095-4dannjjm 4095 25 . . . cord-023095-4dannjjm 4096 1 Urine urine NN cord-023095-4dannjjm 4096 2 concentrations concentration NNS cord-023095-4dannjjm 4096 3 of of IN cord-023095-4dannjjm 4096 4 purine purine NN cord-023095-4dannjjm 4096 5 metabolites metabolite NNS cord-023095-4dannjjm 4096 6 were be VBD cord-023095-4dannjjm 4096 7 measured measure VBN cord-023095-4dannjjm 4096 8 by by IN cord-023095-4dannjjm 4096 9 high high JJ cord-023095-4dannjjm 4096 10 - - HYPH cord-023095-4dannjjm 4096 11 performance performance NN cord-023095-4dannjjm 4096 12 liquid liquid NN cord-023095-4dannjjm 4096 13 chromatography chromatography NN cord-023095-4dannjjm 4096 14 in in IN cord-023095-4dannjjm 4096 15 5 5 CD cord-023095-4dannjjm 4096 16 cats cat NNS cord-023095-4dannjjm 4096 17 with with IN cord-023095-4dannjjm 4096 18 ammonium ammonium NN cord-023095-4dannjjm 4096 19 uroliths urolith NNS cord-023095-4dannjjm 4096 20 ( ( -LRB- cord-023095-4dannjjm 4096 21 cases case NNS cord-023095-4dannjjm 4096 22 ) ) -RRB- cord-023095-4dannjjm 4096 23 , , , cord-023095-4dannjjm 4096 24 5 5 CD cord-023095-4dannjjm 4096 25 clinically clinically RB cord-023095-4dannjjm 4096 26 healthy healthy JJ cord-023095-4dannjjm 4096 27 , , , cord-023095-4dannjjm 4096 28 breed breed NN cord-023095-4dannjjm 4096 29 and and CC cord-023095-4dannjjm 4096 30 gender gender NN cord-023095-4dannjjm 4096 31 matched match VBN cord-023095-4dannjjm 4096 32 cats cat NNS cord-023095-4dannjjm 4096 33 ( ( -LRB- cord-023095-4dannjjm 4096 34 negative negative JJ cord-023095-4dannjjm 4096 35 controls control NNS cord-023095-4dannjjm 4096 36 ) ) -RRB- cord-023095-4dannjjm 4096 37 , , , cord-023095-4dannjjm 4096 38 and and CC cord-023095-4dannjjm 4096 39 2 2 CD cord-023095-4dannjjm 4096 40 cats cat NNS cord-023095-4dannjjm 4096 41 with with IN cord-023095-4dannjjm 4096 42 naturally naturally RB cord-023095-4dannjjm 4096 43 occurring occur VBG cord-023095-4dannjjm 4096 44 xanthine xanthine NN cord-023095-4dannjjm 4096 45 uroliths urolith NNS cord-023095-4dannjjm 4096 46 ( ( -LRB- cord-023095-4dannjjm 4096 47 positive positive JJ cord-023095-4dannjjm 4096 48 controls control NNS cord-023095-4dannjjm 4096 49 ) ) -RRB- cord-023095-4dannjjm 4096 50 . . . cord-023095-4dannjjm 4097 1 Prior prior RB cord-023095-4dannjjm 4097 2 to to IN cord-023095-4dannjjm 4097 3 urine urine NN cord-023095-4dannjjm 4097 4 collection collection NN cord-023095-4dannjjm 4097 5 , , , cord-023095-4dannjjm 4097 6 all all DT cord-023095-4dannjjm 4097 7 cats cat NNS cord-023095-4dannjjm 4097 8 were be VBD cord-023095-4dannjjm 4097 9 fed feed VBN cord-023095-4dannjjm 4097 10 a a DT cord-023095-4dannjjm 4097 11 standard standard JJ cord-023095-4dannjjm 4097 12 maintenance maintenance NN cord-023095-4dannjjm 4097 13 food food NN cord-023095-4dannjjm 4097 14 ( ( -LRB- cord-023095-4dannjjm 4097 15 protein protein NN cord-023095-4dannjjm 4097 16 5 5 CD cord-023095-4dannjjm 4097 17 7 7 CD cord-023095-4dannjjm 4097 18 g/100kcal g/100kcal NNP cord-023095-4dannjjm 4097 19 ) ) -RRB- cord-023095-4dannjjm 4097 20 for for IN cord-023095-4dannjjm 4097 21 4 4 CD cord-023095-4dannjjm 4097 22 weeks week NNS cord-023095-4dannjjm 4097 23 . . . cord-023095-4dannjjm 4098 1 Urinary urinary JJ cord-023095-4dannjjm 4098 2 xanthine xanthine NN cord-023095-4dannjjm 4098 3 , , , cord-023095-4dannjjm 4098 4 uric uric NN cord-023095-4dannjjm 4098 5 acid acid NN cord-023095-4dannjjm 4098 6 , , , cord-023095-4dannjjm 4098 7 and and CC cord-023095-4dannjjm 4098 8 allantoin allantoin NN cord-023095-4dannjjm 4098 9 concentrations concentration NNS cord-023095-4dannjjm 4098 10 and and CC cord-023095-4dannjjm 4098 11 concentration concentration NN cord-023095-4dannjjm 4098 12 to to IN cord-023095-4dannjjm 4098 13 creatinine creatinine NN cord-023095-4dannjjm 4098 14 ratios ratio NNS cord-023095-4dannjjm 4098 15 were be VBD cord-023095-4dannjjm 4098 16 calculated calculate VBN cord-023095-4dannjjm 4098 17 and and CC cord-023095-4dannjjm 4098 18 compared compare VBN cord-023095-4dannjjm 4098 19 between between IN cord-023095-4dannjjm 4098 20 groups group NNS cord-023095-4dannjjm 4098 21 . . . cord-023095-4dannjjm 4099 1 Also also RB cord-023095-4dannjjm 4099 2 , , , cord-023095-4dannjjm 4099 3 serum serum NN cord-023095-4dannjjm 4099 4 pre pre VB cord-023095-4dannjjm 4099 5 - - JJ cord-023095-4dannjjm 4099 6 and and CC cord-023095-4dannjjm 4099 7 post post JJ cord-023095-4dannjjm 4099 8 - - JJ cord-023095-4dannjjm 4099 9 prandial prandial JJ cord-023095-4dannjjm 4099 10 bile bile NN cord-023095-4dannjjm 4099 11 acid acid NN cord-023095-4dannjjm 4099 12 concentrations concentration NNS cord-023095-4dannjjm 4099 13 were be VBD cord-023095-4dannjjm 4099 14 measured measure VBN cord-023095-4dannjjm 4099 15 . . . cord-023095-4dannjjm 4100 1 When when WRB cord-023095-4dannjjm 4100 2 compared compare VBN cord-023095-4dannjjm 4100 3 to to TO cord-023095-4dannjjm 4100 4 control control VB cord-023095-4dannjjm 4100 5 cats cat NNS cord-023095-4dannjjm 4100 6 , , , cord-023095-4dannjjm 4100 7 urinary urinary JJ cord-023095-4dannjjm 4100 8 uric uric NN cord-023095-4dannjjm 4100 9 acid acid NN cord-023095-4dannjjm 4100 10 concentration concentration NN cord-023095-4dannjjm 4100 11 was be VBD cord-023095-4dannjjm 4100 12 significantly significantly RB cord-023095-4dannjjm 4100 13 higher high JJR cord-023095-4dannjjm 4100 14 in in IN cord-023095-4dannjjm 4100 15 case case NN cord-023095-4dannjjm 4100 16 cats cat NNS cord-023095-4dannjjm 4100 17 ( ( -LRB- cord-023095-4dannjjm 4100 18 P p NN cord-023095-4dannjjm 4100 19 5 5 CD cord-023095-4dannjjm 4100 20 0.002 0.002 CD cord-023095-4dannjjm 4100 21 ) ) -RRB- cord-023095-4dannjjm 4100 22 . . . cord-023095-4dannjjm 4101 1 Xanthine Xanthine NNP cord-023095-4dannjjm 4101 2 was be VBD cord-023095-4dannjjm 4101 3 not not RB cord-023095-4dannjjm 4101 4 detected detect VBN cord-023095-4dannjjm 4101 5 in in IN cord-023095-4dannjjm 4101 6 the the DT cord-023095-4dannjjm 4101 7 urine urine NN cord-023095-4dannjjm 4101 8 of of IN cord-023095-4dannjjm 4101 9 cases case NNS cord-023095-4dannjjm 4101 10 or or CC cord-023095-4dannjjm 4101 11 negative negative JJ cord-023095-4dannjjm 4101 12 controls control NNS cord-023095-4dannjjm 4101 13 . . . cord-023095-4dannjjm 4102 1 A a DT cord-023095-4dannjjm 4102 2 significant significant JJ cord-023095-4dannjjm 4102 3 difference difference NN cord-023095-4dannjjm 4102 4 in in IN cord-023095-4dannjjm 4102 5 fasted fast VBN cord-023095-4dannjjm 4102 6 and and CC cord-023095-4dannjjm 4102 7 post post JJ cord-023095-4dannjjm 4102 8 - - JJ cord-023095-4dannjjm 4102 9 prandial prandial JJ cord-023095-4dannjjm 4102 10 serum serum NN cord-023095-4dannjjm 4102 11 bile bile NN cord-023095-4dannjjm 4102 12 acid acid NN cord-023095-4dannjjm 4102 13 concentrations concentration NNS cord-023095-4dannjjm 4102 14 was be VBD cord-023095-4dannjjm 4102 15 not not RB cord-023095-4dannjjm 4102 16 detected detect VBN cord-023095-4dannjjm 4102 17 in in IN cord-023095-4dannjjm 4102 18 cases case NNS cord-023095-4dannjjm 4102 19 or or CC cord-023095-4dannjjm 4102 20 controls control NNS cord-023095-4dannjjm 4102 21 ( ( -LRB- cord-023095-4dannjjm 4102 22 P p NN cord-023095-4dannjjm 4102 23 5 5 CD cord-023095-4dannjjm 4102 24 0.197 0.197 CD cord-023095-4dannjjm 4102 25 , , , cord-023095-4dannjjm 4102 26 0.212).Hyperuricosuria 0.212).hyperuricosuria CD cord-023095-4dannjjm 4102 27 without without IN cord-023095-4dannjjm 4102 28 increased increase VBN cord-023095-4dannjjm 4102 29 concentrations concentration NNS cord-023095-4dannjjm 4102 30 of of IN cord-023095-4dannjjm 4102 31 urinary urinary JJ cord-023095-4dannjjm 4102 32 xanthine xanthine NN cord-023095-4dannjjm 4102 33 or or CC cord-023095-4dannjjm 4102 34 allantoin allantoin NN cord-023095-4dannjjm 4102 35 appears appear VBZ cord-023095-4dannjjm 4102 36 to to TO cord-023095-4dannjjm 4102 37 be be VB cord-023095-4dannjjm 4102 38 a a DT cord-023095-4dannjjm 4102 39 risk risk NN cord-023095-4dannjjm 4102 40 factor factor NN cord-023095-4dannjjm 4102 41 for for IN cord-023095-4dannjjm 4102 42 ammonium ammonium NN cord-023095-4dannjjm 4102 43 urate urate NN cord-023095-4dannjjm 4102 44 urolith urolith NN cord-023095-4dannjjm 4102 45 formation formation NN cord-023095-4dannjjm 4102 46 in in IN cord-023095-4dannjjm 4102 47 cats cat NNS cord-023095-4dannjjm 4102 48 . . . cord-023095-4dannjjm 4103 1 An an DT cord-023095-4dannjjm 4103 2 association association NN cord-023095-4dannjjm 4103 3 between between IN cord-023095-4dannjjm 4103 4 portovascular portovascular NNP cord-023095-4dannjjm 4103 5 shunts shunt NNS cord-023095-4dannjjm 4103 6 and and CC cord-023095-4dannjjm 4103 7 purine purine NNP cord-023095-4dannjjm 4103 8 urolithiasis urolithiasis NN cord-023095-4dannjjm 4103 9 was be VBD cord-023095-4dannjjm 4103 10 not not RB cord-023095-4dannjjm 4103 11 observed observe VBN cord-023095-4dannjjm 4103 12 in in IN cord-023095-4dannjjm 4103 13 this this DT cord-023095-4dannjjm 4103 14 population population NN cord-023095-4dannjjm 4103 15 of of IN cord-023095-4dannjjm 4103 16 cats cat NNS cord-023095-4dannjjm 4103 17 . . . cord-023095-4dannjjm 4104 1 Studies study NNS cord-023095-4dannjjm 4104 2 indicate indicate VBP cord-023095-4dannjjm 4104 3 that that IN cord-023095-4dannjjm 4104 4 proteinuria proteinuria NN cord-023095-4dannjjm 4104 5 is be VBZ cord-023095-4dannjjm 4104 6 predictive predictive JJ cord-023095-4dannjjm 4104 7 , , , cord-023095-4dannjjm 4104 8 on on IN cord-023095-4dannjjm 4104 9 a a DT cord-023095-4dannjjm 4104 10 population population NN cord-023095-4dannjjm 4104 11 basis basis NN cord-023095-4dannjjm 4104 12 , , , cord-023095-4dannjjm 4104 13 of of IN cord-023095-4dannjjm 4104 14 those those DT cord-023095-4dannjjm 4104 15 cats cat NNS cord-023095-4dannjjm 4104 16 at at IN cord-023095-4dannjjm 4104 17 risk risk NN cord-023095-4dannjjm 4104 18 of of IN cord-023095-4dannjjm 4104 19 developing develop VBG cord-023095-4dannjjm 4104 20 azotemia azotemia NN cord-023095-4dannjjm 4104 21 . . . cord-023095-4dannjjm 4105 1 SELDI SELDI NNP cord-023095-4dannjjm 4105 2 - - HYPH cord-023095-4dannjjm 4105 3 TOF TOF NNP cord-023095-4dannjjm 4105 4 - - HYPH cord-023095-4dannjjm 4105 5 MS MS NNP cord-023095-4dannjjm 4105 6 is be VBZ cord-023095-4dannjjm 4105 7 a a DT cord-023095-4dannjjm 4105 8 sensitive sensitive JJ cord-023095-4dannjjm 4105 9 , , , cord-023095-4dannjjm 4105 10 high high JJ cord-023095-4dannjjm 4105 11 - - HYPH cord-023095-4dannjjm 4105 12 throughput throughput NN cord-023095-4dannjjm 4105 13 , , , cord-023095-4dannjjm 4105 14 proteomic proteomic JJ cord-023095-4dannjjm 4105 15 technique technique NN cord-023095-4dannjjm 4105 16 utilising utilise VBG cord-023095-4dannjjm 4105 17 chromatographic chromatographic JJ cord-023095-4dannjjm 4105 18 surfaces surface NNS cord-023095-4dannjjm 4105 19 to to TO cord-023095-4dannjjm 4105 20 facilitate facilitate VB cord-023095-4dannjjm 4105 21 separation separation NN cord-023095-4dannjjm 4105 22 and and CC cord-023095-4dannjjm 4105 23 detection detection NN cord-023095-4dannjjm 4105 24 of of IN cord-023095-4dannjjm 4105 25 proteins protein NNS cord-023095-4dannjjm 4105 26 and and CC cord-023095-4dannjjm 4105 27 peptides peptide NNS cord-023095-4dannjjm 4105 28 within within IN cord-023095-4dannjjm 4105 29 biological biological JJ cord-023095-4dannjjm 4105 30 fluids fluid NNS cord-023095-4dannjjm 4105 31 such such JJ cord-023095-4dannjjm 4105 32 as as IN cord-023095-4dannjjm 4105 33 urine urine NN cord-023095-4dannjjm 4105 34 . . . cord-023095-4dannjjm 4106 1 Individual individual JJ cord-023095-4dannjjm 4106 2 low low JJ cord-023095-4dannjjm 4106 3 molecular molecular JJ cord-023095-4dannjjm 4106 4 weight weight NN cord-023095-4dannjjm 4106 5 ( ( -LRB- cord-023095-4dannjjm 4106 6 LMW LMW NNP cord-023095-4dannjjm 4106 7 ) ) -RRB- cord-023095-4dannjjm 4106 8 urinary urinary JJ cord-023095-4dannjjm 4106 9 proteins protein NNS cord-023095-4dannjjm 4106 10 have have VBP cord-023095-4dannjjm 4106 11 been be VBN cord-023095-4dannjjm 4106 12 considered consider VBN cord-023095-4dannjjm 4106 13 as as IN cord-023095-4dannjjm 4106 14 potential potential JJ cord-023095-4dannjjm 4106 15 biomarkers biomarker NNS cord-023095-4dannjjm 4106 16 for for IN cord-023095-4dannjjm 4106 17 renal renal JJ cord-023095-4dannjjm 4106 18 damage damage NN cord-023095-4dannjjm 4106 19 but but CC cord-023095-4dannjjm 4106 20 provide provide VBP cord-023095-4dannjjm 4106 21 only only RB cord-023095-4dannjjm 4106 22 a a DT cord-023095-4dannjjm 4106 23 limited limited JJ cord-023095-4dannjjm 4106 24 representation representation NN cord-023095-4dannjjm 4106 25 of of IN cord-023095-4dannjjm 4106 26 the the DT cord-023095-4dannjjm 4106 27 urinary urinary JJ cord-023095-4dannjjm 4106 28 proteome proteome NN cord-023095-4dannjjm 4106 29 ; ; : cord-023095-4dannjjm 4106 30 SELDI SELDI NNP cord-023095-4dannjjm 4106 31 - - HYPH cord-023095-4dannjjm 4106 32 TOF TOF NNP cord-023095-4dannjjm 4106 33 - - HYPH cord-023095-4dannjjm 4106 34 MS MS NNP cord-023095-4dannjjm 4106 35 may may MD cord-023095-4dannjjm 4106 36 provide provide VB cord-023095-4dannjjm 4106 37 a a DT cord-023095-4dannjjm 4106 38 more more RBR cord-023095-4dannjjm 4106 39 global global JJ cord-023095-4dannjjm 4106 40 assessment assessment NN cord-023095-4dannjjm 4106 41 . . . cord-023095-4dannjjm 4107 1 Normotensive Normotensive NNP cord-023095-4dannjjm 4107 2 , , , cord-023095-4dannjjm 4107 3 non non JJ cord-023095-4dannjjm 4107 4 - - JJ cord-023095-4dannjjm 4107 5 azotemic azotemic JJ cord-023095-4dannjjm 4107 6 geriatric geriatric JJ cord-023095-4dannjjm 4107 7 cats cat NNS cord-023095-4dannjjm 4107 8 ( ( -LRB- cord-023095-4dannjjm 4107 9 4 4 CD cord-023095-4dannjjm 4107 10 9 9 CD cord-023095-4dannjjm 4107 11 years year NNS cord-023095-4dannjjm 4107 12 ) ) -RRB- cord-023095-4dannjjm 4107 13 were be VBD cord-023095-4dannjjm 4107 14 recruited recruit VBN cord-023095-4dannjjm 4107 15 prospectively prospectively RB cord-023095-4dannjjm 4107 16 from from IN cord-023095-4dannjjm 4107 17 two two CD cord-023095-4dannjjm 4107 18 first first JJ cord-023095-4dannjjm 4107 19 - - HYPH cord-023095-4dannjjm 4107 20 opinion opinion NN cord-023095-4dannjjm 4107 21 clinics clinic NNS cord-023095-4dannjjm 4107 22 for for IN cord-023095-4dannjjm 4107 23 routine routine JJ cord-023095-4dannjjm 4107 24 health health NN cord-023095-4dannjjm 4107 25 screening screening NN cord-023095-4dannjjm 4107 26 . . . cord-023095-4dannjjm 4108 1 At at IN cord-023095-4dannjjm 4108 2 entry entry NN cord-023095-4dannjjm 4108 3 cats cat NNS cord-023095-4dannjjm 4108 4 received receive VBD cord-023095-4dannjjm 4108 5 a a DT cord-023095-4dannjjm 4108 6 full full JJ cord-023095-4dannjjm 4108 7 physical physical JJ cord-023095-4dannjjm 4108 8 examination examination NN cord-023095-4dannjjm 4108 9 , , , cord-023095-4dannjjm 4108 10 plasma plasma NN cord-023095-4dannjjm 4108 11 biochemistry biochemistry NN cord-023095-4dannjjm 4108 12 , , , cord-023095-4dannjjm 4108 13 evaluation evaluation NN cord-023095-4dannjjm 4108 14 of of IN cord-023095-4dannjjm 4108 15 total total JJ cord-023095-4dannjjm 4108 16 T4 T4 NNP cord-023095-4dannjjm 4108 17 concentration concentration NN cord-023095-4dannjjm 4108 18 and and CC cord-023095-4dannjjm 4108 19 urinalysis urinalysis NN cord-023095-4dannjjm 4108 20 including include VBG cord-023095-4dannjjm 4108 21 urine urine NN cord-023095-4dannjjm 4108 22 protein protein NN cord-023095-4dannjjm 4108 23 to to IN cord-023095-4dannjjm 4108 24 creatinine creatinine NN cord-023095-4dannjjm 4108 25 ratio ratio NN cord-023095-4dannjjm 4108 26 . . . cord-023095-4dannjjm 4109 1 Re re NN cord-023095-4dannjjm 4109 2 - - NN cord-023095-4dannjjm 4109 3 examination examination NN cord-023095-4dannjjm 4109 4 was be VBD cord-023095-4dannjjm 4109 5 offered offer VBN cord-023095-4dannjjm 4109 6 at at IN cord-023095-4dannjjm 4109 7 6 6 CD cord-023095-4dannjjm 4109 8 and and CC cord-023095-4dannjjm 4109 9 12 12 CD cord-023095-4dannjjm 4109 10 months month NNS cord-023095-4dannjjm 4109 11 . . . cord-023095-4dannjjm 4110 1 Cats cat NNS cord-023095-4dannjjm 4110 2 were be VBD cord-023095-4dannjjm 4110 3 divided divide VBN cord-023095-4dannjjm 4110 4 into into IN cord-023095-4dannjjm 4110 5 two two CD cord-023095-4dannjjm 4110 6 groups group NNS cord-023095-4dannjjm 4110 7 based base VBN cord-023095-4dannjjm 4110 8 on on IN cord-023095-4dannjjm 4110 9 clinical clinical JJ cord-023095-4dannjjm 4110 10 status status NN cord-023095-4dannjjm 4110 11 at at IN cord-023095-4dannjjm 4110 12 the the DT cord-023095-4dannjjm 4110 13 12 12 CD cord-023095-4dannjjm 4110 14 month month NN cord-023095-4dannjjm 4110 15 re re NN cord-023095-4dannjjm 4110 16 - - NN cord-023095-4dannjjm 4110 17 examination examination NN cord-023095-4dannjjm 4110 18 ( ( -LRB- cord-023095-4dannjjm 4110 19 azotemic azotemic NN cord-023095-4dannjjm 4110 20 ; ; : cord-023095-4dannjjm 4110 21 creatinine creatinine NN cord-023095-4dannjjm 4110 22 concentration concentration NN cord-023095-4dannjjm 4110 23 ! ! . cord-023095-4dannjjm 4111 1 2.0 2.0 CD cord-023095-4dannjjm 4112 1 mg mg NNP cord-023095-4dannjjm 4112 2 / / SYM cord-023095-4dannjjm 4112 3 dL dl NN cord-023095-4dannjjm 4112 4 and and CC cord-023095-4dannjjm 4112 5 non non JJ cord-023095-4dannjjm 4112 6 - - JJ cord-023095-4dannjjm 4112 7 azotemic azotemic JJ cord-023095-4dannjjm 4112 8 ) ) -RRB- cord-023095-4dannjjm 4112 9 . . . cord-023095-4dannjjm 4113 1 Optimisation optimisation NN cord-023095-4dannjjm 4113 2 studies study NNS cord-023095-4dannjjm 4113 3 were be VBD cord-023095-4dannjjm 4113 4 performed perform VBN cord-023095-4dannjjm 4113 5 to to TO cord-023095-4dannjjm 4113 6 facilitate facilitate VB cord-023095-4dannjjm 4113 7 the the DT cord-023095-4dannjjm 4113 8 automated automate VBN cord-023095-4dannjjm 4113 9 preparation preparation NN cord-023095-4dannjjm 4113 10 ( ( -LRB- cord-023095-4dannjjm 4113 11 Biomek Biomek NNP cord-023095-4dannjjm 4113 12 3000 3000 CD cord-023095-4dannjjm 4113 13 ) ) -RRB- cord-023095-4dannjjm 4113 14 of of IN cord-023095-4dannjjm 4113 15 CM10 CM10 NNP cord-023095-4dannjjm 4113 16 ( ( -LRB- cord-023095-4dannjjm 4113 17 weak weak NNP cord-023095-4dannjjm 4113 18 cation cation NNP cord-023095-4dannjjm 4113 19 exchange exchange NN cord-023095-4dannjjm 4113 20 ) ) -RRB- cord-023095-4dannjjm 4113 21 arrays array NNS cord-023095-4dannjjm 4113 22 for for IN cord-023095-4dannjjm 4113 23 SELDI SELDI NNP cord-023095-4dannjjm 4113 24 - - HYPH cord-023095-4dannjjm 4113 25 TOF TOF NNP cord-023095-4dannjjm 4113 26 - - HYPH cord-023095-4dannjjm 4113 27 MS MS NNP cord-023095-4dannjjm 4113 28 analysis analysis NN cord-023095-4dannjjm 4114 1 ( ( -LRB- cord-023095-4dannjjm 4114 2 Ciphergen Ciphergen NNP cord-023095-4dannjjm 4114 3 Enterprise Enterprise NNP cord-023095-4dannjjm 4114 4 4000 4000 CD cord-023095-4dannjjm 4114 5 ) ) -RRB- cord-023095-4dannjjm 4114 6 of of IN cord-023095-4dannjjm 4114 7 urine urine NN cord-023095-4dannjjm 4114 8 samples sample NNS cord-023095-4dannjjm 4114 9 from from IN cord-023095-4dannjjm 4114 10 cats cat NNS cord-023095-4dannjjm 4114 11 at at IN cord-023095-4dannjjm 4114 12 entry entry NN cord-023095-4dannjjm 4114 13 to to IN cord-023095-4dannjjm 4114 14 the the DT cord-023095-4dannjjm 4114 15 study study NN cord-023095-4dannjjm 4114 16 . . . cord-023095-4dannjjm 4115 1 Results result NNS cord-023095-4dannjjm 4115 2 are be VBP cord-023095-4dannjjm 4115 3 reported report VBN cord-023095-4dannjjm 4115 4 as as IN cord-023095-4dannjjm 4115 5 median median JJ cord-023095-4dannjjm 4115 6 [ [ -LRB- cord-023095-4dannjjm 4115 7 25 25 CD cord-023095-4dannjjm 4115 8 th th XX cord-023095-4dannjjm 4115 9 , , , cord-023095-4dannjjm 4115 10 75 75 CD cord-023095-4dannjjm 4115 11 th th XX cord-023095-4dannjjm 4115 12 percentile percentile NN cord-023095-4dannjjm 4115 13 ] ] -RRB- cord-023095-4dannjjm 4115 14 . . . cord-023095-4dannjjm 4116 1 Mann Mann NNP cord-023095-4dannjjm 4116 2 Whitney Whitney NNP cord-023095-4dannjjm 4116 3 U U NNP cord-023095-4dannjjm 4116 4 - - HYPH cord-023095-4dannjjm 4116 5 test test NN cord-023095-4dannjjm 4116 6 and and CC cord-023095-4dannjjm 4116 7 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 4116 8 signed sign VBD cord-023095-4dannjjm 4116 9 rank rank NN cord-023095-4dannjjm 4116 10 test test NN cord-023095-4dannjjm 4116 11 were be VBD cord-023095-4dannjjm 4116 12 used use VBN cord-023095-4dannjjm 4116 13 to to TO cord-023095-4dannjjm 4116 14 compare compare VB cord-023095-4dannjjm 4116 15 variables variable NNS cord-023095-4dannjjm 4116 16 between between IN cord-023095-4dannjjm 4116 17 groups group NNS cord-023095-4dannjjm 4116 18 and and CC cord-023095-4dannjjm 4116 19 between between IN cord-023095-4dannjjm 4116 20 timepoints timepoint NNS cord-023095-4dannjjm 4116 21 , , , cord-023095-4dannjjm 4116 22 respectively respectively RB cord-023095-4dannjjm 4116 23 . . . cord-023095-4dannjjm 4117 1 Ciphergen Ciphergen NNP cord-023095-4dannjjm 4117 2 Express Express NNP cord-023095-4dannjjm 4117 3 ( ( -LRB- cord-023095-4dannjjm 4117 4 3.06 3.06 CD cord-023095-4dannjjm 4117 5 ) ) -RRB- cord-023095-4dannjjm 4117 6 software software NN cord-023095-4dannjjm 4117 7 was be VBD cord-023095-4dannjjm 4117 8 used use VBN cord-023095-4dannjjm 4117 9 to to TO cord-023095-4dannjjm 4117 10 analyse analyse VB cord-023095-4dannjjm 4117 11 spectral spectral JJ cord-023095-4dannjjm 4117 12 data datum NNS cord-023095-4dannjjm 4117 13 and and CC cord-023095-4dannjjm 4117 14 a a DT cord-023095-4dannjjm 4117 15 Mann Mann NNP cord-023095-4dannjjm 4117 16 Whitney Whitney NNP cord-023095-4dannjjm 4117 17 U U NNP cord-023095-4dannjjm 4117 18 - - HYPH cord-023095-4dannjjm 4117 19 test test NN cord-023095-4dannjjm 4117 20 was be VBD cord-023095-4dannjjm 4117 21 used use VBN cord-023095-4dannjjm 4117 22 to to TO cord-023095-4dannjjm 4117 23 identify identify VB cord-023095-4dannjjm 4117 24 clusters cluster NNS cord-023095-4dannjjm 4117 25 which which WDT cord-023095-4dannjjm 4117 26 differed differ VBD cord-023095-4dannjjm 4117 27 significantly significantly RB cord-023095-4dannjjm 4117 28 between between IN cord-023095-4dannjjm 4117 29 groups group NNS cord-023095-4dannjjm 4117 30 ( ( -LRB- cord-023095-4dannjjm 4117 31 p p NN cord-023095-4dannjjm 4117 32 o o NN cord-023095-4dannjjm 4117 33 0.05 0.05 CD cord-023095-4dannjjm 4117 34 ) ) -RRB- cord-023095-4dannjjm 4117 35 at at IN cord-023095-4dannjjm 4117 36 entry entry NN cord-023095-4dannjjm 4117 37 to to IN cord-023095-4dannjjm 4117 38 the the DT cord-023095-4dannjjm 4117 39 study study NN cord-023095-4dannjjm 4117 40 . . . cord-023095-4dannjjm 4118 1 Twenty twenty CD cord-023095-4dannjjm 4118 2 non non JJ cord-023095-4dannjjm 4118 3 - - JJ cord-023095-4dannjjm 4118 4 azotemic azotemic JJ cord-023095-4dannjjm 4118 5 cats cat NNS cord-023095-4dannjjm 4118 6 were be VBD cord-023095-4dannjjm 4118 7 recruited recruit VBN cord-023095-4dannjjm 4118 8 , , , cord-023095-4dannjjm 4118 9 of of IN cord-023095-4dannjjm 4118 10 which which WDT cord-023095-4dannjjm 4118 11 10 10 CD cord-023095-4dannjjm 4118 12 cats cat NNS cord-023095-4dannjjm 4118 13 developed develop VBD cord-023095-4dannjjm 4118 14 azotemia azotemia NN cord-023095-4dannjjm 4118 15 by by IN cord-023095-4dannjjm 4118 16 12 12 CD cord-023095-4dannjjm 4118 17 months month NNS cord-023095-4dannjjm 4118 18 . . . cord-023095-4dannjjm 4119 1 No no DT cord-023095-4dannjjm 4119 2 significant significant JJ cord-023095-4dannjjm 4119 3 differences difference NNS cord-023095-4dannjjm 4119 4 in in IN cord-023095-4dannjjm 4119 5 age age NN cord-023095-4dannjjm 4119 6 , , , cord-023095-4dannjjm 4119 7 body body NN cord-023095-4dannjjm 4119 8 weight weight NN cord-023095-4dannjjm 4119 9 , , , cord-023095-4dannjjm 4119 10 biochemical biochemical JJ cord-023095-4dannjjm 4119 11 or or CC cord-023095-4dannjjm 4119 12 urinalysis urinalysis JJ cord-023095-4dannjjm 4119 13 variables variable NNS cord-023095-4dannjjm 4119 14 were be VBD cord-023095-4dannjjm 4119 15 identified identify VBN cord-023095-4dannjjm 4119 16 between between IN cord-023095-4dannjjm 4119 17 groups group NNS cord-023095-4dannjjm 4119 18 at at IN cord-023095-4dannjjm 4119 19 entry entry NN cord-023095-4dannjjm 4119 20 to to IN cord-023095-4dannjjm 4119 21 the the DT cord-023095-4dannjjm 4119 22 study study NN cord-023095-4dannjjm 4119 23 . . . cord-023095-4dannjjm 4120 1 As as IN cord-023095-4dannjjm 4120 2 might may MD cord-023095-4dannjjm 4120 3 be be VB cord-023095-4dannjjm 4120 4 expected expect VBN cord-023095-4dannjjm 4120 5 creatinine creatinine NN cord-023095-4dannjjm 4120 6 increased increase VBD cord-023095-4dannjjm 4120 7 significantly significantly RB cord-023095-4dannjjm 4120 8 ( ( -LRB- cord-023095-4dannjjm 4120 9 1.73 1.73 CD cord-023095-4dannjjm 4120 10 mg mg NNP cord-023095-4dannjjm 4120 11 / / SYM cord-023095-4dannjjm 4120 12 dL dl NN cord-023095-4dannjjm 4120 13 [ [ -LRB- cord-023095-4dannjjm 4120 14 1.58 1.58 CD cord-023095-4dannjjm 4120 15 , , , cord-023095-4dannjjm 4120 16 1.77 1.77 CD cord-023095-4dannjjm 4120 17 ] ] -RRB- cord-023095-4dannjjm 4120 18 , , , cord-023095-4dannjjm 4120 19 2.17 2.17 CD cord-023095-4dannjjm 4120 20 [ [ -LRB- cord-023095-4dannjjm 4120 21 2.00 2.00 CD cord-023095-4dannjjm 4120 22 , , , cord-023095-4dannjjm 4120 23 3.23 3.23 CD cord-023095-4dannjjm 4120 24 ] ] -RRB- cord-023095-4dannjjm 4120 25 , , , cord-023095-4dannjjm 4120 26 p p NN cord-023095-4dannjjm 4120 27 5 5 CD cord-023095-4dannjjm 4120 28 0.002 0.002 CD cord-023095-4dannjjm 4120 29 ) ) -RRB- cord-023095-4dannjjm 4120 30 between between IN cord-023095-4dannjjm 4120 31 study study NN cord-023095-4dannjjm 4120 32 entry entry NN cord-023095-4dannjjm 4120 33 and and CC cord-023095-4dannjjm 4120 34 12 12 CD cord-023095-4dannjjm 4120 35 months month NNS cord-023095-4dannjjm 4120 36 in in IN cord-023095-4dannjjm 4120 37 the the DT cord-023095-4dannjjm 4120 38 cats cat NNS cord-023095-4dannjjm 4120 39 that that WDT cord-023095-4dannjjm 4120 40 developed develop VBD cord-023095-4dannjjm 4120 41 azotaemia azotaemia NN cord-023095-4dannjjm 4120 42 and and CC cord-023095-4dannjjm 4120 43 there there EX cord-023095-4dannjjm 4120 44 was be VBD cord-023095-4dannjjm 4120 45 a a DT cord-023095-4dannjjm 4120 46 commensurate commensurate JJ cord-023095-4dannjjm 4120 47 increase increase NN cord-023095-4dannjjm 4120 48 in in IN cord-023095-4dannjjm 4120 49 phosphate phosphate NN cord-023095-4dannjjm 4120 50 concentration concentration NN cord-023095-4dannjjm 4120 51 ( ( -LRB- cord-023095-4dannjjm 4120 52 3.81 3.81 CD cord-023095-4dannjjm 4120 53 mg mg NNP cord-023095-4dannjjm 4120 54 / / SYM cord-023095-4dannjjm 4120 55 dL dl NN cord-023095-4dannjjm 4120 56 [ [ -LRB- cord-023095-4dannjjm 4120 57 3.60 3.60 CD cord-023095-4dannjjm 4120 58 , , , cord-023095-4dannjjm 4120 59 4.22 4.22 CD cord-023095-4dannjjm 4120 60 ] ] -RRB- cord-023095-4dannjjm 4120 61 , , , cord-023095-4dannjjm 4120 62 4.65[3.94 4.65[3.94 CD cord-023095-4dannjjm 4120 63 , , , cord-023095-4dannjjm 4120 64 6 6 CD cord-023095-4dannjjm 4120 65 .48 .48 CD cord-023095-4dannjjm 4120 66 ] ] -RRB- cord-023095-4dannjjm 4120 67 , , . cord-023095-4dannjjm 4121 1 p p NN cord-023095-4dannjjm 4121 2 5 5 CD cord-023095-4dannjjm 4121 3 0.019 0.019 CD cord-023095-4dannjjm 4121 4 ) ) -RRB- cord-023095-4dannjjm 4121 5 . . . cord-023095-4dannjjm 4122 1 Creatinine creatinine NN cord-023095-4dannjjm 4122 2 and and CC cord-023095-4dannjjm 4122 3 phosphorus phosphorus NN cord-023095-4dannjjm 4122 4 did do VBD cord-023095-4dannjjm 4122 5 not not RB cord-023095-4dannjjm 4122 6 change change VB cord-023095-4dannjjm 4122 7 significantly significantly RB cord-023095-4dannjjm 4122 8 over over IN cord-023095-4dannjjm 4122 9 time time NN cord-023095-4dannjjm 4122 10 in in IN cord-023095-4dannjjm 4122 11 the the DT cord-023095-4dannjjm 4122 12 cats cat NNS cord-023095-4dannjjm 4122 13 that that WDT cord-023095-4dannjjm 4122 14 did do VBD cord-023095-4dannjjm 4122 15 not not RB cord-023095-4dannjjm 4122 16 develop develop VB cord-023095-4dannjjm 4122 17 azotaemia azotaemia NNP cord-023095-4dannjjm 4122 18 . . . cord-023095-4dannjjm 4123 1 Seven seven CD cord-023095-4dannjjm 4123 2 clusters cluster NNS cord-023095-4dannjjm 4123 3 with with IN cord-023095-4dannjjm 4123 4 m m NN cord-023095-4dannjjm 4123 5 / / SYM cord-023095-4dannjjm 4123 6 z z NN cord-023095-4dannjjm 4123 7 values value NNS cord-023095-4dannjjm 4123 8 of of IN cord-023095-4dannjjm 4123 9 2822 2822 CD cord-023095-4dannjjm 4123 10 , , , cord-023095-4dannjjm 4123 11 10 10 CD cord-023095-4dannjjm 4123 12 033 033 CD cord-023095-4dannjjm 4123 13 , , , cord-023095-4dannjjm 4123 14 10 10 CD cord-023095-4dannjjm 4123 15 151 151 CD cord-023095-4dannjjm 4123 16 , , , cord-023095-4dannjjm 4123 17 10 10 CD cord-023095-4dannjjm 4123 18 234 234 CD cord-023095-4dannjjm 4123 19 , , , cord-023095-4dannjjm 4123 20 11 11 CD cord-023095-4dannjjm 4123 21 635 635 CD cord-023095-4dannjjm 4123 22 , , , cord-023095-4dannjjm 4123 23 11 11 CD cord-023095-4dannjjm 4123 24 700 700 CD cord-023095-4dannjjm 4123 25 were be VBD cord-023095-4dannjjm 4123 26 found find VBN cord-023095-4dannjjm 4123 27 to to TO cord-023095-4dannjjm 4123 28 differ differ VB cord-023095-4dannjjm 4123 29 significantly significantly RB cord-023095-4dannjjm 4123 30 between between IN cord-023095-4dannjjm 4123 31 groups group NNS cord-023095-4dannjjm 4123 32 at at IN cord-023095-4dannjjm 4123 33 entry entry NN cord-023095-4dannjjm 4123 34 to to IN cord-023095-4dannjjm 4123 35 the the DT cord-023095-4dannjjm 4123 36 study study NN cord-023095-4dannjjm 4123 37 . . . cord-023095-4dannjjm 4124 1 The the DT cord-023095-4dannjjm 4124 2 low low JJ cord-023095-4dannjjm 4124 3 protein protein NN cord-023095-4dannjjm 4124 4 concentration concentration NN cord-023095-4dannjjm 4124 5 of of IN cord-023095-4dannjjm 4124 6 feline feline JJ cord-023095-4dannjjm 4124 7 urine urine NN cord-023095-4dannjjm 4124 8 makes make VBZ cord-023095-4dannjjm 4124 9 the the DT cord-023095-4dannjjm 4124 10 use use NN cord-023095-4dannjjm 4124 11 of of IN cord-023095-4dannjjm 4124 12 proteomic proteomic JJ cord-023095-4dannjjm 4124 13 techniques technique NNS cord-023095-4dannjjm 4124 14 challenging challenge VBG cord-023095-4dannjjm 4124 15 . . . cord-023095-4dannjjm 4125 1 However however RB cord-023095-4dannjjm 4125 2 , , , cord-023095-4dannjjm 4125 3 this this DT cord-023095-4dannjjm 4125 4 pilot pilot NN cord-023095-4dannjjm 4125 5 study study NN cord-023095-4dannjjm 4125 6 indicates indicate VBZ cord-023095-4dannjjm 4125 7 that that IN cord-023095-4dannjjm 4125 8 SELDI SELDI NNP cord-023095-4dannjjm 4125 9 - - HYPH cord-023095-4dannjjm 4125 10 TOF TOF NNP cord-023095-4dannjjm 4125 11 - - HYPH cord-023095-4dannjjm 4125 12 MS MS NNP cord-023095-4dannjjm 4125 13 can can MD cord-023095-4dannjjm 4125 14 be be VB cord-023095-4dannjjm 4125 15 utilised utilise VBN cord-023095-4dannjjm 4125 16 to to TO cord-023095-4dannjjm 4125 17 examine examine VB cord-023095-4dannjjm 4125 18 the the DT cord-023095-4dannjjm 4125 19 feline feline JJ cord-023095-4dannjjm 4125 20 urinary urinary JJ cord-023095-4dannjjm 4125 21 proteome proteome NN cord-023095-4dannjjm 4125 22 and and CC cord-023095-4dannjjm 4125 23 that that IN cord-023095-4dannjjm 4125 24 differences difference NNS cord-023095-4dannjjm 4125 25 in in IN cord-023095-4dannjjm 4125 26 low low JJ cord-023095-4dannjjm 4125 27 molecular molecular JJ cord-023095-4dannjjm 4125 28 weight weight NN cord-023095-4dannjjm 4125 29 protein protein NN cord-023095-4dannjjm 4125 30 patterns pattern NNS cord-023095-4dannjjm 4125 31 may may MD cord-023095-4dannjjm 4125 32 be be VB cord-023095-4dannjjm 4125 33 useful useful JJ cord-023095-4dannjjm 4125 34 to to TO cord-023095-4dannjjm 4125 35 differentiate differentiate VB cord-023095-4dannjjm 4125 36 those those DT cord-023095-4dannjjm 4125 37 cats cat NNS cord-023095-4dannjjm 4125 38 which which WDT cord-023095-4dannjjm 4125 39 are be VBP cord-023095-4dannjjm 4125 40 at at IN cord-023095-4dannjjm 4125 41 risk risk NN cord-023095-4dannjjm 4125 42 of of IN cord-023095-4dannjjm 4125 43 the the DT cord-023095-4dannjjm 4125 44 development development NN cord-023095-4dannjjm 4125 45 of of IN cord-023095-4dannjjm 4125 46 azotemia azotemia NN cord-023095-4dannjjm 4125 47 . . . cord-023095-4dannjjm 4126 1 Further further JJ cord-023095-4dannjjm 4126 2 work work NN cord-023095-4dannjjm 4126 3 is be VBZ cord-023095-4dannjjm 4126 4 necessary necessary JJ cord-023095-4dannjjm 4126 5 to to TO cord-023095-4dannjjm 4126 6 identify identify VB cord-023095-4dannjjm 4126 7 these these DT cord-023095-4dannjjm 4126 8 proteins protein NNS cord-023095-4dannjjm 4126 9 / / SYM cord-023095-4dannjjm 4126 10 peptides peptide NNS cord-023095-4dannjjm 4126 11 . . . cord-023095-4dannjjm 4127 1 Fibroblastic Fibroblastic NNP cord-023095-4dannjjm 4127 2 Growth Growth NNP cord-023095-4dannjjm 4127 3 Factor Factor NNP cord-023095-4dannjjm 4127 4 23 23 CD cord-023095-4dannjjm 4127 5 ( ( -LRB- cord-023095-4dannjjm 4127 6 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4127 7 ) ) -RRB- cord-023095-4dannjjm 4127 8 is be VBZ cord-023095-4dannjjm 4127 9 a a DT cord-023095-4dannjjm 4127 10 phosphotonin phosphotonin NN cord-023095-4dannjjm 4127 11 with with IN cord-023095-4dannjjm 4127 12 an an DT cord-023095-4dannjjm 4127 13 important important JJ cord-023095-4dannjjm 4127 14 physiological physiological JJ cord-023095-4dannjjm 4127 15 role role NN cord-023095-4dannjjm 4127 16 in in IN cord-023095-4dannjjm 4127 17 the the DT cord-023095-4dannjjm 4127 18 regulation regulation NN cord-023095-4dannjjm 4127 19 of of IN cord-023095-4dannjjm 4127 20 phosphorous phosphorous NN cord-023095-4dannjjm 4127 21 and and CC cord-023095-4dannjjm 4127 22 vitamin vitamin NN cord-023095-4dannjjm 4127 23 D d NN cord-023095-4dannjjm 4127 24 metabolism metabolism NN cord-023095-4dannjjm 4127 25 , , , cord-023095-4dannjjm 4127 26 and and CC cord-023095-4dannjjm 4127 27 may may MD cord-023095-4dannjjm 4127 28 therefore therefore RB cord-023095-4dannjjm 4127 29 play play VB cord-023095-4dannjjm 4127 30 a a DT cord-023095-4dannjjm 4127 31 part part NN cord-023095-4dannjjm 4127 32 in in IN cord-023095-4dannjjm 4127 33 the the DT cord-023095-4dannjjm 4127 34 development development NN cord-023095-4dannjjm 4127 35 of of IN cord-023095-4dannjjm 4127 36 renal renal JJ cord-023095-4dannjjm 4127 37 secondary secondary JJ cord-023095-4dannjjm 4127 38 hyperparathyroidism hyperparathyroidism NN cord-023095-4dannjjm 4127 39 . . . cord-023095-4dannjjm 4128 1 Previous previous JJ cord-023095-4dannjjm 4128 2 studies study NNS cord-023095-4dannjjm 4128 3 in in IN cord-023095-4dannjjm 4128 4 cats cat NNS cord-023095-4dannjjm 4128 5 have have VBP cord-023095-4dannjjm 4128 6 shown show VBN cord-023095-4dannjjm 4128 7 parathyroid parathyroid JJ cord-023095-4dannjjm 4128 8 hormone hormone NN cord-023095-4dannjjm 4128 9 ( ( -LRB- cord-023095-4dannjjm 4128 10 PTH PTH NNP cord-023095-4dannjjm 4128 11 ) ) -RRB- cord-023095-4dannjjm 4128 12 to to TO cord-023095-4dannjjm 4128 13 be be VB cord-023095-4dannjjm 4128 14 elevated elevate VBN cord-023095-4dannjjm 4128 15 prior prior RB cord-023095-4dannjjm 4128 16 to to IN cord-023095-4dannjjm 4128 17 the the DT cord-023095-4dannjjm 4128 18 development development NN cord-023095-4dannjjm 4128 19 of of IN cord-023095-4dannjjm 4128 20 azotemia azotemia NN cord-023095-4dannjjm 4128 21 . . . cord-023095-4dannjjm 4129 1 The the DT cord-023095-4dannjjm 4129 2 study study NN cord-023095-4dannjjm 4129 3 objectives objective NNS cord-023095-4dannjjm 4129 4 were be VBD cord-023095-4dannjjm 4129 5 to to TO cord-023095-4dannjjm 4129 6 explore explore VB cord-023095-4dannjjm 4129 7 the the DT cord-023095-4dannjjm 4129 8 hypothesis hypothesis NN cord-023095-4dannjjm 4129 9 that that IN cord-023095-4dannjjm 4129 10 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4129 11 is be VBZ cord-023095-4dannjjm 4129 12 a a DT cord-023095-4dannjjm 4129 13 mediator mediator NN cord-023095-4dannjjm 4129 14 of of IN cord-023095-4dannjjm 4129 15 the the DT cord-023095-4dannjjm 4129 16 development development NN cord-023095-4dannjjm 4129 17 of of IN cord-023095-4dannjjm 4129 18 renal renal JJ cord-023095-4dannjjm 4129 19 secondary secondary JJ cord-023095-4dannjjm 4129 20 hyperparathyroidism hyperparathyroidism NN cord-023095-4dannjjm 4129 21 in in IN cord-023095-4dannjjm 4129 22 the the DT cord-023095-4dannjjm 4129 23 nonazotemic nonazotemic JJ cord-023095-4dannjjm 4129 24 stages stage NNS cord-023095-4dannjjm 4129 25 of of IN cord-023095-4dannjjm 4129 26 feline feline JJ cord-023095-4dannjjm 4129 27 CKD CKD NNP cord-023095-4dannjjm 4129 28 . . . cord-023095-4dannjjm 4130 1 Healthy healthy JJ cord-023095-4dannjjm 4130 2 , , , cord-023095-4dannjjm 4130 3 non non JJ cord-023095-4dannjjm 4130 4 - - JJ cord-023095-4dannjjm 4130 5 azotemic azotemic JJ cord-023095-4dannjjm 4130 6 ( ( -LRB- cord-023095-4dannjjm 4130 7 plasma plasma NN cord-023095-4dannjjm 4130 8 creatinine creatinine NN cord-023095-4dannjjm 4130 9 concentrations concentration NNS cord-023095-4dannjjm 4131 1 ( ( -LRB- cord-023095-4dannjjm 4131 2 Cr Cr NNP cord-023095-4dannjjm 4131 3 ) ) -RRB- cord-023095-4dannjjm 4131 4 o o NN cord-023095-4dannjjm 4131 5 2.0 2.0 CD cord-023095-4dannjjm 4132 1 mg mg NNP cord-023095-4dannjjm 4132 2 / / SYM cord-023095-4dannjjm 4132 3 dl dl NNP cord-023095-4dannjjm 4132 4 ) ) -RRB- cord-023095-4dannjjm 4132 5 geriatric geriatric JJ cord-023095-4dannjjm 4132 6 cats cat NNS cord-023095-4dannjjm 4132 7 were be VBD cord-023095-4dannjjm 4132 8 recruited recruit VBN cord-023095-4dannjjm 4132 9 into into IN cord-023095-4dannjjm 4132 10 the the DT cord-023095-4dannjjm 4132 11 study study NN cord-023095-4dannjjm 4132 12 prospectively prospectively RB cord-023095-4dannjjm 4132 13 and and CC cord-023095-4dannjjm 4132 14 followed follow VBD cord-023095-4dannjjm 4132 15 for for IN cord-023095-4dannjjm 4132 16 12 12 CD cord-023095-4dannjjm 4132 17 months month NNS cord-023095-4dannjjm 4132 18 . . . cord-023095-4dannjjm 4133 1 At at IN cord-023095-4dannjjm 4133 2 the the DT cord-023095-4dannjjm 4133 3 study study NN cord-023095-4dannjjm 4133 4 end end NN cord-023095-4dannjjm 4133 5 point point NN cord-023095-4dannjjm 4133 6 cats cat NNS cord-023095-4dannjjm 4133 7 were be VBD cord-023095-4dannjjm 4133 8 categorised categorise VBN cord-023095-4dannjjm 4133 9 into into IN cord-023095-4dannjjm 4133 10 the the DT cord-023095-4dannjjm 4133 11 following following JJ cord-023095-4dannjjm 4133 12 3 3 CD cord-023095-4dannjjm 4133 13 groups group NNS cord-023095-4dannjjm 4133 14 : : : cord-023095-4dannjjm 4133 15 group group NN cord-023095-4dannjjm 4133 16 1 1 CD cord-023095-4dannjjm 4134 1 ( ( -LRB- cord-023095-4dannjjm 4134 2 N n CD cord-023095-4dannjjm 4134 3 5 5 CD cord-023095-4dannjjm 4134 4 15)-Cr 15)-cr CD cord-023095-4dannjjm 4134 5 1.58 1.58 CD cord-023095-4dannjjm 4134 6 mg mg NNP cord-023095-4dannjjm 4134 7 / / SYM cord-023095-4dannjjm 4134 8 dl dl NNP cord-023095-4dannjjm 4134 9 , , , cord-023095-4dannjjm 4134 10 group group NN cord-023095-4dannjjm 4134 11 2 2 CD cord-023095-4dannjjm 4134 12 ( ( -LRB- cord-023095-4dannjjm 4134 13 N n CD cord-023095-4dannjjm 4134 14 5 5 CD cord-023095-4dannjjm 4134 15 33)-Cr 33)-cr CD cord-023095-4dannjjm 4134 16 ! ! . cord-023095-4dannjjm 4135 1 1.58 1.58 CD cord-023095-4dannjjm 4135 2 mg mg NNP cord-023095-4dannjjm 4135 3 / / SYM cord-023095-4dannjjm 4135 4 dl dl NN cord-023095-4dannjjm 4136 1 but but CC cord-023095-4dannjjm 4136 2 did do VBD cord-023095-4dannjjm 4136 3 not not RB cord-023095-4dannjjm 4136 4 meet meet VB cord-023095-4dannjjm 4136 5 the the DT cord-023095-4dannjjm 4136 6 criteria criterion NNS cord-023095-4dannjjm 4136 7 for for IN cord-023095-4dannjjm 4136 8 group group NN cord-023095-4dannjjm 4136 9 3 3 CD cord-023095-4dannjjm 4136 10 and and CC cord-023095-4dannjjm 4136 11 group group NN cord-023095-4dannjjm 4136 12 3 3 CD cord-023095-4dannjjm 4137 1 ( ( -LRB- cord-023095-4dannjjm 4137 2 N N NNP cord-023095-4dannjjm 4137 3 5 5 CD cord-023095-4dannjjm 4137 4 14)-Cr 14)-cr CD cord-023095-4dannjjm 4137 5 4 4 CD cord-023095-4dannjjm 4137 6 2.0 2.0 CD cord-023095-4dannjjm 4137 7 mg mg NNP cord-023095-4dannjjm 4137 8 / / SYM cord-023095-4dannjjm 4137 9 dl dl NNP cord-023095-4dannjjm 4137 10 in in IN cord-023095-4dannjjm 4137 11 association association NN cord-023095-4dannjjm 4137 12 with with IN cord-023095-4dannjjm 4137 13 reduced reduce VBN cord-023095-4dannjjm 4137 14 urine urine NN cord-023095-4dannjjm 4137 15 concentrating concentrate VBG cord-023095-4dannjjm 4137 16 ability ability NN cord-023095-4dannjjm 4137 17 ( ( -LRB- cord-023095-4dannjjm 4137 18 USG USG NNP cord-023095-4dannjjm 4137 19 o o CD cord-023095-4dannjjm 4137 20 1.035 1.035 CD cord-023095-4dannjjm 4137 21 ) ) -RRB- cord-023095-4dannjjm 4137 22 or or CC cord-023095-4dannjjm 4137 23 demonstration demonstration NN cord-023095-4dannjjm 4137 24 of of IN cord-023095-4dannjjm 4137 25 persistent persistent JJ cord-023095-4dannjjm 4137 26 azotemia azotemia NN cord-023095-4dannjjm 4138 1 ( ( -LRB- cord-023095-4dannjjm 4138 2 Cr Cr NNP cord-023095-4dannjjm 4138 3 4 4 CD cord-023095-4dannjjm 4138 4 2.0 2.0 CD cord-023095-4dannjjm 4138 5 mg mg NNP cord-023095-4dannjjm 4138 6 / / SYM cord-023095-4dannjjm 4138 7 dl dl NNP cord-023095-4dannjjm 4138 8 ) ) -RRB- cord-023095-4dannjjm 4138 9 . . . cord-023095-4dannjjm 4139 1 Plasma plasma NN cord-023095-4dannjjm 4139 2 samples sample NNS cord-023095-4dannjjm 4139 3 were be VBD cord-023095-4dannjjm 4139 4 subjected subject VBN cord-023095-4dannjjm 4139 5 to to IN cord-023095-4dannjjm 4139 6 routine routine JJ cord-023095-4dannjjm 4139 7 biochemical biochemical JJ cord-023095-4dannjjm 4139 8 analysis analysis NN cord-023095-4dannjjm 4139 9 , , , cord-023095-4dannjjm 4139 10 intact intact JJ cord-023095-4dannjjm 4139 11 PTH PTH NNP cord-023095-4dannjjm 4139 12 , , , cord-023095-4dannjjm 4139 13 calcitriol calcitriol NN cord-023095-4dannjjm 4139 14 and and CC cord-023095-4dannjjm 4139 15 intact intact JJ cord-023095-4dannjjm 4139 16 FGF-23 fgf-23 CD cord-023095-4dannjjm 4139 17 assay assay NN cord-023095-4dannjjm 4139 18 . . . cord-023095-4dannjjm 4140 1 Variables variable NNS cord-023095-4dannjjm 4140 2 were be VBD cord-023095-4dannjjm 4140 3 compared compare VBN cord-023095-4dannjjm 4140 4 between between IN cord-023095-4dannjjm 4140 5 the the DT cord-023095-4dannjjm 4140 6 3 3 CD cord-023095-4dannjjm 4140 7 groups group NNS cord-023095-4dannjjm 4140 8 at at IN cord-023095-4dannjjm 4140 9 the the DT cord-023095-4dannjjm 4140 10 baseline baseline JJ cord-023095-4dannjjm 4140 11 time time NN cord-023095-4dannjjm 4140 12 point point NN cord-023095-4dannjjm 4140 13 . . . cord-023095-4dannjjm 4141 1 GFR GFR NNP cord-023095-4dannjjm 4141 2 was be VBD cord-023095-4dannjjm 4141 3 measured measure VBN cord-023095-4dannjjm 4141 4 in in IN cord-023095-4dannjjm 4141 5 an an DT cord-023095-4dannjjm 4141 6 additional additional JJ cord-023095-4dannjjm 4141 7 group group NN cord-023095-4dannjjm 4141 8 of of IN cord-023095-4dannjjm 4141 9 19 19 CD cord-023095-4dannjjm 4141 10 cats cat NNS cord-023095-4dannjjm 4141 11 ( ( -LRB- cord-023095-4dannjjm 4141 12 11 11 CD cord-023095-4dannjjm 4141 13 non non JJ cord-023095-4dannjjm 4141 14 - - JJ cord-023095-4dannjjm 4141 15 azotemic azotemic JJ cord-023095-4dannjjm 4141 16 , , , cord-023095-4dannjjm 4141 17 4 4 CD cord-023095-4dannjjm 4141 18 IRIS IRIS NNP cord-023095-4dannjjm 4141 19 stage stage NN cord-023095-4dannjjm 4141 20 II II NNP cord-023095-4dannjjm 4141 21 , , , cord-023095-4dannjjm 4141 22 4 4 CD cord-023095-4dannjjm 4141 23 IRIS IRIS NNP cord-023095-4dannjjm 4141 24 stage stage NN cord-023095-4dannjjm 4141 25 III III NNP cord-023095-4dannjjm 4141 26 ) ) -RRB- cord-023095-4dannjjm 4141 27 using use VBG cord-023095-4dannjjm 4141 28 a a DT cord-023095-4dannjjm 4141 29 corrected correct VBN cord-023095-4dannjjm 4141 30 slope slope NN cord-023095-4dannjjm 4141 31 - - HYPH cord-023095-4dannjjm 4141 32 intercept intercept VB cord-023095-4dannjjm 4141 33 iohexol iohexol NN cord-023095-4dannjjm 4141 34 clearance clearance NN cord-023095-4dannjjm 4141 35 method method NN cord-023095-4dannjjm 4141 36 . . . cord-023095-4dannjjm 4142 1 Relationships relationship NNS cord-023095-4dannjjm 4142 2 were be VBD cord-023095-4dannjjm 4142 3 explored explore VBN cord-023095-4dannjjm 4142 4 using use VBG cord-023095-4dannjjm 4142 5 linear linear JJ cord-023095-4dannjjm 4142 6 regression regression NN cord-023095-4dannjjm 4142 7 analysis analysis NN cord-023095-4dannjjm 4142 8 and and CC cord-023095-4dannjjm 4142 9 determining determine VBG cord-023095-4dannjjm 4142 10 the the DT cord-023095-4dannjjm 4142 11 coefficient coefficient NN cord-023095-4dannjjm 4142 12 of of IN cord-023095-4dannjjm 4142 13 determination determination NN cord-023095-4dannjjm 4142 14 ( ( -LRB- cord-023095-4dannjjm 4142 15 R R NNP cord-023095-4dannjjm 4142 16 2 2 CD cord-023095-4dannjjm 4142 17 ) ) -RRB- cord-023095-4dannjjm 4142 18 . . . cord-023095-4dannjjm 4143 1 Results result NNS cord-023095-4dannjjm 4143 2 are be VBP cord-023095-4dannjjm 4143 3 presented present VBN cord-023095-4dannjjm 4143 4 as as IN cord-023095-4dannjjm 4143 5 median median JJ cord-023095-4dannjjm 4143 6 [ [ -LRB- cord-023095-4dannjjm 4143 7 range range NN cord-023095-4dannjjm 4143 8 ] ] -RRB- cord-023095-4dannjjm 4143 9 . . . cord-023095-4dannjjm 4144 1 At at IN cord-023095-4dannjjm 4144 2 the the DT cord-023095-4dannjjm 4144 3 baseline baseline JJ cord-023095-4dannjjm 4144 4 time time NN cord-023095-4dannjjm 4144 5 point point NN cord-023095-4dannjjm 4144 6 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4144 7 concentrations concentration NNS cord-023095-4dannjjm 4144 8 were be VBD cord-023095-4dannjjm 4144 9 significantly significantly RB cord-023095-4dannjjm 4144 10 higher high JJR cord-023095-4dannjjm 4144 11 in in IN cord-023095-4dannjjm 4144 12 group group NN cord-023095-4dannjjm 4144 13 2 2 CD cord-023095-4dannjjm 4144 14 ( ( -LRB- cord-023095-4dannjjm 4144 15 208.1[51.4 208.1[51.4 CD cord-023095-4dannjjm 4144 16 - - HYPH cord-023095-4dannjjm 4144 17 814.6 814.6 CD cord-023095-4dannjjm 4144 18 ] ] -RRB- cord-023095-4dannjjm 4144 19 , , , cord-023095-4dannjjm 4144 20 P p NN cord-023095-4dannjjm 4144 21 5 5 CD cord-023095-4dannjjm 4144 22 0.001 0.001 CD cord-023095-4dannjjm 4144 23 ) ) -RRB- cord-023095-4dannjjm 4144 24 and and CC cord-023095-4dannjjm 4144 25 group group NN cord-023095-4dannjjm 4144 26 3 3 CD cord-023095-4dannjjm 4144 27 ( ( -LRB- cord-023095-4dannjjm 4144 28 237.6[127.4 237.6[127.4 CD cord-023095-4dannjjm 4144 29 - - HYPH cord-023095-4dannjjm 4144 30 908.1 908.1 CD cord-023095-4dannjjm 4144 31 ] ] -RRB- cord-023095-4dannjjm 4144 32 , , , cord-023095-4dannjjm 4144 33 P p NN cord-023095-4dannjjm 4144 34 5 5 CD cord-023095-4dannjjm 4144 35 0.001 0.001 CD cord-023095-4dannjjm 4144 36 ) ) -RRB- cord-023095-4dannjjm 4144 37 compared compare VBN cord-023095-4dannjjm 4144 38 to to IN cord-023095-4dannjjm 4144 39 group group NN cord-023095-4dannjjm 4144 40 1 1 CD cord-023095-4dannjjm 4144 41 ( ( -LRB- cord-023095-4dannjjm 4144 42 126.2[69.4 126.2[69.4 NNP cord-023095-4dannjjm 4144 43 - - HYPH cord-023095-4dannjjm 4144 44 505.2 505.2 CD cord-023095-4dannjjm 4144 45 ] ] -RRB- cord-023095-4dannjjm 4144 46 ) ) -RRB- cord-023095-4dannjjm 4144 47 . . . cord-023095-4dannjjm 4145 1 Weak weak JJ cord-023095-4dannjjm 4145 2 positive positive JJ cord-023095-4dannjjm 4145 3 relationships relationship NNS cord-023095-4dannjjm 4145 4 were be VBD cord-023095-4dannjjm 4145 5 identified identify VBN cord-023095-4dannjjm 4145 6 between between IN cord-023095-4dannjjm 4145 7 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4145 8 and and CC cord-023095-4dannjjm 4145 9 PTH PTH NNP cord-023095-4dannjjm 4145 10 ( ( -LRB- cord-023095-4dannjjm 4145 11 R r NN cord-023095-4dannjjm 4145 12 2 2 CD cord-023095-4dannjjm 4145 13 5 5 CD cord-023095-4dannjjm 4145 14 0.126 0.126 CD cord-023095-4dannjjm 4145 15 , , , cord-023095-4dannjjm 4145 16 P p NN cord-023095-4dannjjm 4145 17 5 5 CD cord-023095-4dannjjm 4145 18 0.005 0.005 CD cord-023095-4dannjjm 4145 19 , , , cord-023095-4dannjjm 4145 20 N n CD cord-023095-4dannjjm 4145 21 5 5 CD cord-023095-4dannjjm 4145 22 62 62 CD cord-023095-4dannjjm 4145 23 ) ) -RRB- cord-023095-4dannjjm 4145 24 and and CC cord-023095-4dannjjm 4146 1 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4146 2 and and CC cord-023095-4dannjjm 4146 3 Cr Cr NNP cord-023095-4dannjjm 4146 4 ( ( -LRB- cord-023095-4dannjjm 4146 5 R r NN cord-023095-4dannjjm 4146 6 2 2 CD cord-023095-4dannjjm 4146 7 5 5 CD cord-023095-4dannjjm 4146 8 0.077 0.077 CD cord-023095-4dannjjm 4146 9 , , , cord-023095-4dannjjm 4147 1 P p NN cord-023095-4dannjjm 4147 2 5 5 CD cord-023095-4dannjjm 4147 3 0.029 0.029 CD cord-023095-4dannjjm 4147 4 , , , cord-023095-4dannjjm 4147 5 N n CD cord-023095-4dannjjm 4147 6 5 5 CD cord-023095-4dannjjm 4147 7 62 62 CD cord-023095-4dannjjm 4147 8 ) ) -RRB- cord-023095-4dannjjm 4147 9 . . . cord-023095-4dannjjm 4148 1 However however RB cord-023095-4dannjjm 4148 2 , , , cord-023095-4dannjjm 4148 3 the the DT cord-023095-4dannjjm 4148 4 positive positive JJ cord-023095-4dannjjm 4148 5 relationships relationship NNS cord-023095-4dannjjm 4148 6 between between IN cord-023095-4dannjjm 4148 7 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4148 8 and and CC cord-023095-4dannjjm 4148 9 phosphate phosphate NN cord-023095-4dannjjm 4148 10 ( ( -LRB- cord-023095-4dannjjm 4148 11 R r NN cord-023095-4dannjjm 4148 12 2 2 CD cord-023095-4dannjjm 4148 13 5 5 CD cord-023095-4dannjjm 4148 14 0.016 0.016 CD cord-023095-4dannjjm 4148 15 , , , cord-023095-4dannjjm 4148 16 P p NN cord-023095-4dannjjm 4148 17 5 5 CD cord-023095-4dannjjm 4148 18 0.323 0.323 CD cord-023095-4dannjjm 4148 19 , , , cord-023095-4dannjjm 4148 20 N n CD cord-023095-4dannjjm 4148 21 5 5 CD cord-023095-4dannjjm 4148 22 62 62 CD cord-023095-4dannjjm 4148 23 ) ) -RRB- cord-023095-4dannjjm 4148 24 and and CC cord-023095-4dannjjm 4148 25 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4149 1 and and CC cord-023095-4dannjjm 4149 2 calcitriol calcitriol NNP cord-023095-4dannjjm 4149 3 ( ( -LRB- cord-023095-4dannjjm 4149 4 R R NNP cord-023095-4dannjjm 4149 5 2 2 CD cord-023095-4dannjjm 4149 6 5 5 CD cord-023095-4dannjjm 4149 7 0.085 0.085 CD cord-023095-4dannjjm 4149 8 , , , cord-023095-4dannjjm 4149 9 P p NN cord-023095-4dannjjm 4149 10 5 5 CD cord-023095-4dannjjm 4149 11 0.212 0.212 CD cord-023095-4dannjjm 4149 12 , , . cord-023095-4dannjjm 4150 1 N n NN cord-023095-4dannjjm 4150 2 5 5 CD cord-023095-4dannjjm 4150 3 20 20 CD cord-023095-4dannjjm 4150 4 ) ) -RRB- cord-023095-4dannjjm 4150 5 were be VBD cord-023095-4dannjjm 4150 6 not not RB cord-023095-4dannjjm 4150 7 significant significant JJ cord-023095-4dannjjm 4150 8 . . . cord-023095-4dannjjm 4151 1 The the DT cord-023095-4dannjjm 4151 2 additional additional JJ cord-023095-4dannjjm 4151 3 group group NN cord-023095-4dannjjm 4151 4 of of IN cord-023095-4dannjjm 4151 5 cats cat NNS cord-023095-4dannjjm 4151 6 in in IN cord-023095-4dannjjm 4151 7 which which WDT cord-023095-4dannjjm 4151 8 GFR GFR NNP cord-023095-4dannjjm 4151 9 measurement measurement NN cord-023095-4dannjjm 4151 10 was be VBD cord-023095-4dannjjm 4151 11 performed perform VBN cord-023095-4dannjjm 4151 12 there there EX cord-023095-4dannjjm 4151 13 was be VBD cord-023095-4dannjjm 4151 14 an an DT cord-023095-4dannjjm 4151 15 inverse inverse JJ cord-023095-4dannjjm 4151 16 relationship relationship NN cord-023095-4dannjjm 4151 17 between between IN cord-023095-4dannjjm 4151 18 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4151 19 and and CC cord-023095-4dannjjm 4151 20 GFR GFR NNP cord-023095-4dannjjm 4152 1 ( ( -LRB- cord-023095-4dannjjm 4152 2 R r NN cord-023095-4dannjjm 4152 3 2 2 CD cord-023095-4dannjjm 4152 4 5 5 CD cord-023095-4dannjjm 4152 5 0.208 0.208 CD cord-023095-4dannjjm 4152 6 , , , cord-023095-4dannjjm 4152 7 P p NN cord-023095-4dannjjm 4152 8 5 5 CD cord-023095-4dannjjm 4152 9 0.040 0.040 CD cord-023095-4dannjjm 4152 10 ) ) -RRB- cord-023095-4dannjjm 4152 11 . . . cord-023095-4dannjjm 4153 1 In in IN cord-023095-4dannjjm 4153 2 conclusion conclusion NN cord-023095-4dannjjm 4153 3 , , , cord-023095-4dannjjm 4153 4 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4153 5 was be VBD cord-023095-4dannjjm 4153 6 elevated elevate VBN cord-023095-4dannjjm 4153 7 in in IN cord-023095-4dannjjm 4153 8 cats cat NNS cord-023095-4dannjjm 4153 9 prior prior RB cord-023095-4dannjjm 4153 10 to to IN cord-023095-4dannjjm 4153 11 the the DT cord-023095-4dannjjm 4153 12 development development NN cord-023095-4dannjjm 4153 13 of of IN cord-023095-4dannjjm 4153 14 azotemia azotemia NN cord-023095-4dannjjm 4153 15 . . . cord-023095-4dannjjm 4154 1 The the DT cord-023095-4dannjjm 4154 2 role role NN cord-023095-4dannjjm 4154 3 of of IN cord-023095-4dannjjm 4154 4 FGF-23 FGF-23 NNPS cord-023095-4dannjjm 4154 5 in in IN cord-023095-4dannjjm 4154 6 the the DT cord-023095-4dannjjm 4154 7 development development NN cord-023095-4dannjjm 4154 8 of of IN cord-023095-4dannjjm 4154 9 feline feline JJ cord-023095-4dannjjm 4154 10 renal renal JJ cord-023095-4dannjjm 4154 11 secondary secondary JJ cord-023095-4dannjjm 4154 12 hyperparathyroidism hyperparathyroidism NN cord-023095-4dannjjm 4154 13 remains remain VBZ cord-023095-4dannjjm 4154 14 to to TO cord-023095-4dannjjm 4154 15 be be VB cord-023095-4dannjjm 4154 16 determined determine VBN cord-023095-4dannjjm 4154 17 and and CC cord-023095-4dannjjm 4154 18 should should MD cord-023095-4dannjjm 4154 19 be be VB cord-023095-4dannjjm 4154 20 explored explore VBN cord-023095-4dannjjm 4154 21 through through IN cord-023095-4dannjjm 4154 22 interventional interventional JJ cord-023095-4dannjjm 4154 23 studies study NNS cord-023095-4dannjjm 4154 24 . . . cord-023095-4dannjjm 4155 1 However however RB cord-023095-4dannjjm 4155 2 , , , cord-023095-4dannjjm 4155 3 considering consider VBG cord-023095-4dannjjm 4155 4 the the DT cord-023095-4dannjjm 4155 5 relationship relationship NN cord-023095-4dannjjm 4155 6 between between IN cord-023095-4dannjjm 4155 7 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4155 8 and and CC cord-023095-4dannjjm 4155 9 GFR GFR NNP cord-023095-4dannjjm 4155 10 , , , cord-023095-4dannjjm 4155 11 it -PRON- PRP cord-023095-4dannjjm 4155 12 can can MD cord-023095-4dannjjm 4155 13 not not RB cord-023095-4dannjjm 4155 14 be be VB cord-023095-4dannjjm 4155 15 excluded exclude VBN cord-023095-4dannjjm 4155 16 that that IN cord-023095-4dannjjm 4155 17 the the DT cord-023095-4dannjjm 4155 18 phosphotonin phosphotonin NN cord-023095-4dannjjm 4155 19 is be VBZ cord-023095-4dannjjm 4155 20 simply simply RB cord-023095-4dannjjm 4155 21 a a DT cord-023095-4dannjjm 4155 22 marker marker NN cord-023095-4dannjjm 4155 23 of of IN cord-023095-4dannjjm 4155 24 reduced reduce VBN cord-023095-4dannjjm 4155 25 filtration filtration NN cord-023095-4dannjjm 4155 26 . . . cord-023095-4dannjjm 4156 1 Chronic chronic JJ cord-023095-4dannjjm 4156 2 kidney kidney NN cord-023095-4dannjjm 4156 3 disease disease NN cord-023095-4dannjjm 4156 4 ( ( -LRB- cord-023095-4dannjjm 4156 5 CKD CKD NNP cord-023095-4dannjjm 4156 6 ) ) -RRB- cord-023095-4dannjjm 4156 7 is be VBZ cord-023095-4dannjjm 4156 8 common common JJ cord-023095-4dannjjm 4156 9 in in IN cord-023095-4dannjjm 4156 10 geriatric geriatric JJ cord-023095-4dannjjm 4156 11 cats cat NNS cord-023095-4dannjjm 4156 12 and and CC cord-023095-4dannjjm 4156 13 hypoxia hypoxia NN cord-023095-4dannjjm 4156 14 might may MD cord-023095-4dannjjm 4156 15 contribute contribute VB cord-023095-4dannjjm 4156 16 to to IN cord-023095-4dannjjm 4156 17 the the DT cord-023095-4dannjjm 4156 18 progression progression NN cord-023095-4dannjjm 4156 19 of of IN cord-023095-4dannjjm 4156 20 this this DT cord-023095-4dannjjm 4156 21 disease disease NN cord-023095-4dannjjm 4156 22 . . . cord-023095-4dannjjm 4157 1 The the DT cord-023095-4dannjjm 4157 2 aim aim NN cord-023095-4dannjjm 4157 3 of of IN cord-023095-4dannjjm 4157 4 this this DT cord-023095-4dannjjm 4157 5 study study NN cord-023095-4dannjjm 4157 6 was be VBD cord-023095-4dannjjm 4157 7 to to TO cord-023095-4dannjjm 4157 8 evaluate evaluate VB cord-023095-4dannjjm 4157 9 urinary urinary JJ cord-023095-4dannjjm 4157 10 vascular vascular JJ cord-023095-4dannjjm 4157 11 endothelial endothelial JJ cord-023095-4dannjjm 4157 12 growth growth NN cord-023095-4dannjjm 4157 13 factor factor NN cord-023095-4dannjjm 4157 14 ( ( -LRB- cord-023095-4dannjjm 4157 15 VEGF VEGF NNP cord-023095-4dannjjm 4157 16 ) ) -RRB- cord-023095-4dannjjm 4157 17 as as IN cord-023095-4dannjjm 4157 18 a a DT cord-023095-4dannjjm 4157 19 marker marker NN cord-023095-4dannjjm 4157 20 of of IN cord-023095-4dannjjm 4157 21 renal renal JJ cord-023095-4dannjjm 4157 22 hypoxia hypoxia NN cord-023095-4dannjjm 4157 23 . . . cord-023095-4dannjjm 4158 1 Cats cat NNS cord-023095-4dannjjm 4158 2 were be VBD cord-023095-4dannjjm 4158 3 recruited recruit VBN cord-023095-4dannjjm 4158 4 through through IN cord-023095-4dannjjm 4158 5 geriatric geriatric JJ cord-023095-4dannjjm 4158 6 clinics clinic NNS cord-023095-4dannjjm 4158 7 held hold VBN cord-023095-4dannjjm 4158 8 at at IN cord-023095-4dannjjm 4158 9 two two CD cord-023095-4dannjjm 4158 10 first first JJ cord-023095-4dannjjm 4158 11 opinion opinion NN cord-023095-4dannjjm 4158 12 London London NNP cord-023095-4dannjjm 4158 13 practices practice NNS cord-023095-4dannjjm 4158 14 . . . cord-023095-4dannjjm 4159 1 VEGF VEGF NNP cord-023095-4dannjjm 4159 2 was be VBD cord-023095-4dannjjm 4159 3 measured measure VBN cord-023095-4dannjjm 4159 4 in in IN cord-023095-4dannjjm 4159 5 stored store VBN cord-023095-4dannjjm 4159 6 samples sample NNS cord-023095-4dannjjm 4159 7 using use VBG cord-023095-4dannjjm 4159 8 a a DT cord-023095-4dannjjm 4159 9 canine canine JJ cord-023095-4dannjjm 4159 10 ELISA ELISA NNP cord-023095-4dannjjm 4159 11 kit kit NN cord-023095-4dannjjm 4159 12 validated validate VBN cord-023095-4dannjjm 4159 13 for for IN cord-023095-4dannjjm 4159 14 use use NN cord-023095-4dannjjm 4159 15 on on IN cord-023095-4dannjjm 4159 16 feline feline JJ cord-023095-4dannjjm 4159 17 urine urine NN cord-023095-4dannjjm 4159 18 and and CC cord-023095-4dannjjm 4159 19 indexed index VBN cord-023095-4dannjjm 4159 20 to to IN cord-023095-4dannjjm 4159 21 creatinine creatinine NN cord-023095-4dannjjm 4159 22 concentration concentration NN cord-023095-4dannjjm 4159 23 to to TO cord-023095-4dannjjm 4159 24 yield yield VB cord-023095-4dannjjm 4159 25 a a DT cord-023095-4dannjjm 4159 26 VEGF vegf NN cord-023095-4dannjjm 4159 27 to to TO cord-023095-4dannjjm 4159 28 creatinine creatinine NN cord-023095-4dannjjm 4159 29 ratio ratio NN cord-023095-4dannjjm 4159 30 ( ( -LRB- cord-023095-4dannjjm 4159 31 VCR VCR NNP cord-023095-4dannjjm 4159 32 ) ) -RRB- cord-023095-4dannjjm 4159 33 . . . cord-023095-4dannjjm 4160 1 Two two CD cord-023095-4dannjjm 4160 2 studies study NNS cord-023095-4dannjjm 4160 3 were be VBD cord-023095-4dannjjm 4160 4 undertaken undertake VBN cord-023095-4dannjjm 4160 5 -firstly -firstly RB cord-023095-4dannjjm 4160 6 a a DT cord-023095-4dannjjm 4160 7 cross cross JJ cord-023095-4dannjjm 4160 8 - - JJ cord-023095-4dannjjm 4160 9 sectional sectional JJ cord-023095-4dannjjm 4160 10 analysis analysis NN cord-023095-4dannjjm 4160 11 of of IN cord-023095-4dannjjm 4160 12 clinical clinical JJ cord-023095-4dannjjm 4160 13 variables variable NNS cord-023095-4dannjjm 4160 14 associated associate VBN cord-023095-4dannjjm 4160 15 with with IN cord-023095-4dannjjm 4160 16 VCR VCR NNP cord-023095-4dannjjm 4160 17 in in IN cord-023095-4dannjjm 4160 18 cats cat NNS cord-023095-4dannjjm 4160 19 with with IN cord-023095-4dannjjm 4160 20 CKD CKD NNP cord-023095-4dannjjm 4160 21 . . . cord-023095-4dannjjm 4161 1 Diagnosis diagnosis NN cord-023095-4dannjjm 4161 2 of of IN cord-023095-4dannjjm 4161 3 CKD CKD NNP cord-023095-4dannjjm 4161 4 was be VBD cord-023095-4dannjjm 4161 5 based base VBN cord-023095-4dannjjm 4161 6 on on IN cord-023095-4dannjjm 4161 7 concurrent concurrent JJ cord-023095-4dannjjm 4161 8 findings finding NNS cord-023095-4dannjjm 4161 9 of of IN cord-023095-4dannjjm 4161 10 plasma plasma NN cord-023095-4dannjjm 4161 11 creatinine creatinine NN cord-023095-4dannjjm 4161 12 ! ! . cord-023095-4dannjjm 4162 1 2 2 LS cord-023095-4dannjjm 4163 1 mg mg NNP cord-023095-4dannjjm 4163 2 / / SYM cord-023095-4dannjjm 4163 3 dl dl NNP cord-023095-4dannjjm 4163 4 and and CC cord-023095-4dannjjm 4163 5 USG USG NNP cord-023095-4dannjjm 4163 6 1.035 1.035 CD cord-023095-4dannjjm 4163 7 , , , cord-023095-4dannjjm 4163 8 with with IN cord-023095-4dannjjm 4163 9 persistence persistence NN cord-023095-4dannjjm 4163 10 of of IN cord-023095-4dannjjm 4163 11 azotemia azotemia NN cord-023095-4dannjjm 4163 12 for for IN cord-023095-4dannjjm 4163 13 ! ! . cord-023095-4dannjjm 4164 1 2 2 CD cord-023095-4dannjjm 4164 2 weeks week NNS cord-023095-4dannjjm 4164 3 . . . cord-023095-4dannjjm 4165 1 Only only RB cord-023095-4dannjjm 4165 2 patients patient NNS cord-023095-4dannjjm 4165 3 receiving receive VBG cord-023095-4dannjjm 4165 4 no no DT cord-023095-4dannjjm 4165 5 medical medical JJ cord-023095-4dannjjm 4165 6 therapies therapy NNS cord-023095-4dannjjm 4165 7 were be VBD cord-023095-4dannjjm 4165 8 included include VBN cord-023095-4dannjjm 4165 9 . . . cord-023095-4dannjjm 4166 1 Normotensive Normotensive NNP cord-023095-4dannjjm 4166 2 and and CC cord-023095-4dannjjm 4166 3 ( ( -LRB- cord-023095-4dannjjm 4166 4 pre pre JJ cord-023095-4dannjjm 4166 5 - - JJ cord-023095-4dannjjm 4166 6 treatment treatment NN cord-023095-4dannjjm 4166 7 ) ) -RRB- cord-023095-4dannjjm 4167 1 hypertensive hypertensive JJ cord-023095-4dannjjm 4167 2 cats cat NNS cord-023095-4dannjjm 4167 3 were be VBD cord-023095-4dannjjm 4167 4 included include VBN cord-023095-4dannjjm 4167 5 , , , cord-023095-4dannjjm 4167 6 but but CC cord-023095-4dannjjm 4167 7 borderline borderline JJ cord-023095-4dannjjm 4167 8 cases case NNS cord-023095-4dannjjm 4167 9 ( ( -LRB- cord-023095-4dannjjm 4167 10 mean mean VB cord-023095-4dannjjm 4167 11 systolic systolic JJ cord-023095-4dannjjm 4167 12 blood blood NN cord-023095-4dannjjm 4167 13 pressure pressure NN cord-023095-4dannjjm 4167 14 160 160 CD cord-023095-4dannjjm 4167 15 - - SYM cord-023095-4dannjjm 4167 16 170 170 CD cord-023095-4dannjjm 4167 17 mmHg mmHg NNS cord-023095-4dannjjm 4167 18 on on IN cord-023095-4dannjjm 4167 19 the the DT cord-023095-4dannjjm 4167 20 date date NN cord-023095-4dannjjm 4167 21 of of IN cord-023095-4dannjjm 4167 22 sampling sampling NN cord-023095-4dannjjm 4167 23 ) ) -RRB- cord-023095-4dannjjm 4167 24 were be VBD cord-023095-4dannjjm 4167 25 not not RB cord-023095-4dannjjm 4167 26 . . . cord-023095-4dannjjm 4168 1 Hyperthyroid Hyperthyroid NNP cord-023095-4dannjjm 4168 2 cats cat NNS cord-023095-4dannjjm 4168 3 were be VBD cord-023095-4dannjjm 4168 4 also also RB cord-023095-4dannjjm 4168 5 excluded exclude VBN cord-023095-4dannjjm 4168 6 from from IN cord-023095-4dannjjm 4168 7 this this DT cord-023095-4dannjjm 4168 8 cross cross JJ cord-023095-4dannjjm 4168 9 - - JJ cord-023095-4dannjjm 4168 10 sectional sectional JJ cord-023095-4dannjjm 4168 11 study study NN cord-023095-4dannjjm 4168 12 . . . cord-023095-4dannjjm 4169 1 Associations association NNS cord-023095-4dannjjm 4169 2 between between IN cord-023095-4dannjjm 4169 3 VCR vcr NN cord-023095-4dannjjm 4169 4 and and CC cord-023095-4dannjjm 4169 5 clinical clinical JJ cord-023095-4dannjjm 4169 6 data datum NNS cord-023095-4dannjjm 4169 7 were be VBD cord-023095-4dannjjm 4169 8 initially initially RB cord-023095-4dannjjm 4169 9 assessed assess VBN cord-023095-4dannjjm 4169 10 using use VBG cord-023095-4dannjjm 4169 11 the the DT cord-023095-4dannjjm 4169 12 Spearman Spearman NNP cord-023095-4dannjjm 4169 13 's 's POS cord-023095-4dannjjm 4169 14 coefficient coefficient NN cord-023095-4dannjjm 4169 15 and and CC cord-023095-4dannjjm 4169 16 Mann Mann NNP cord-023095-4dannjjm 4169 17 Whitney Whitney NNP cord-023095-4dannjjm 4169 18 Test Test NNP cord-023095-4dannjjm 4169 19 . . . cord-023095-4dannjjm 4170 1 Linear linear JJ cord-023095-4dannjjm 4170 2 regression regression NN cord-023095-4dannjjm 4170 3 was be VBD cord-023095-4dannjjm 4170 4 then then RB cord-023095-4dannjjm 4170 5 used use VBN cord-023095-4dannjjm 4170 6 for for IN cord-023095-4dannjjm 4170 7 multivariate multivariate JJ cord-023095-4dannjjm 4170 8 analysis analysis NN cord-023095-4dannjjm 4170 9 . . . cord-023095-4dannjjm 4171 1 The the DT cord-023095-4dannjjm 4171 2 second second JJ cord-023095-4dannjjm 4171 3 study study NN cord-023095-4dannjjm 4171 4 used use VBD cord-023095-4dannjjm 4171 5 samples sample NNS cord-023095-4dannjjm 4171 6 from from IN cord-023095-4dannjjm 4171 7 a a DT cord-023095-4dannjjm 4171 8 trial trial NN cord-023095-4dannjjm 4171 9 in in IN cord-023095-4dannjjm 4171 10 which which WDT cord-023095-4dannjjm 4171 11 hypertensive hypertensive JJ cord-023095-4dannjjm 4171 12 cats cat NNS cord-023095-4dannjjm 4171 13 that that WDT cord-023095-4dannjjm 4171 14 had have VBD cord-023095-4dannjjm 4171 15 been be VBN cord-023095-4dannjjm 4171 16 treated treat VBN cord-023095-4dannjjm 4171 17 with with IN cord-023095-4dannjjm 4171 18 amlodipine amlodipine NN cord-023095-4dannjjm 4171 19 for for IN cord-023095-4dannjjm 4171 20 at at RB cord-023095-4dannjjm 4171 21 least least JJS cord-023095-4dannjjm 4171 22 3 3 CD cord-023095-4dannjjm 4171 23 months month NNS cord-023095-4dannjjm 4171 24 were be VBD cord-023095-4dannjjm 4171 25 entered enter VBN cord-023095-4dannjjm 4171 26 into into IN cord-023095-4dannjjm 4171 27 a a DT cord-023095-4dannjjm 4171 28 randomised randomised JJ cord-023095-4dannjjm 4171 29 cross cross NN cord-023095-4dannjjm 4171 30 - - HYPH cord-023095-4dannjjm 4171 31 over over JJ cord-023095-4dannjjm 4171 32 study study NN cord-023095-4dannjjm 4171 33 where where WRB cord-023095-4dannjjm 4171 34 they -PRON- PRP cord-023095-4dannjjm 4171 35 received receive VBD cord-023095-4dannjjm 4171 36 placebo placebo NN cord-023095-4dannjjm 4171 37 or or CC cord-023095-4dannjjm 4171 38 benazepril benazepril NNP cord-023095-4dannjjm 4171 39 ( ( -LRB- cord-023095-4dannjjm 4171 40 0.5 0.5 CD cord-023095-4dannjjm 4171 41 to to IN cord-023095-4dannjjm 4171 42 1 1 CD cord-023095-4dannjjm 4171 43 mg mg NNP cord-023095-4dannjjm 4171 44 / / SYM cord-023095-4dannjjm 4171 45 kg kg NNP cord-023095-4dannjjm 4171 46 daily daily NN cord-023095-4dannjjm 4171 47 ) ) -RRB- cord-023095-4dannjjm 4171 48 for for IN cord-023095-4dannjjm 4171 49 12 12 CD cord-023095-4dannjjm 4171 50 weeks week NNS cord-023095-4dannjjm 4171 51 in in IN cord-023095-4dannjjm 4171 52 turn turn NN cord-023095-4dannjjm 4171 53 . . . cord-023095-4dannjjm 4172 1 VCR VCR NNP cord-023095-4dannjjm 4172 2 on on IN cord-023095-4dannjjm 4172 3 placebo placebo NN cord-023095-4dannjjm 4172 4 was be VBD cord-023095-4dannjjm 4172 5 compared compare VBN cord-023095-4dannjjm 4172 6 with with IN cord-023095-4dannjjm 4172 7 that that DT cord-023095-4dannjjm 4172 8 on on IN cord-023095-4dannjjm 4172 9 benazepril benazepril NNP cord-023095-4dannjjm 4172 10 using use VBG cord-023095-4dannjjm 4172 11 the the DT cord-023095-4dannjjm 4172 12 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 4172 13 signed sign VBD cord-023095-4dannjjm 4172 14 ranks rank NNS cord-023095-4dannjjm 4172 15 test test NN cord-023095-4dannjjm 4172 16 . . . cord-023095-4dannjjm 4173 1 Cats cat NNS cord-023095-4dannjjm 4173 2 with with IN cord-023095-4dannjjm 4173 3 well well RB cord-023095-4dannjjm 4173 4 controlled control VBN cord-023095-4dannjjm 4173 5 hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 4173 6 were be VBD cord-023095-4dannjjm 4173 7 included include VBN cord-023095-4dannjjm 4173 8 in in IN cord-023095-4dannjjm 4173 9 this this DT cord-023095-4dannjjm 4173 10 intervention intervention NN cord-023095-4dannjjm 4173 11 study study NN cord-023095-4dannjjm 4173 12 . . . cord-023095-4dannjjm 4174 1 Results result NNS cord-023095-4dannjjm 4174 2 are be VBP cord-023095-4dannjjm 4174 3 reported report VBN cord-023095-4dannjjm 4174 4 as as IN cord-023095-4dannjjm 4174 5 median median JJ cord-023095-4dannjjm 4174 6 [ [ -LRB- cord-023095-4dannjjm 4174 7 25th 25th NN cord-023095-4dannjjm 4174 8 , , , cord-023095-4dannjjm 4174 9 75th 75th JJ cord-023095-4dannjjm 4174 10 percentile percentile NN cord-023095-4dannjjm 4174 11 ] ] -RRB- cord-023095-4dannjjm 4174 12 . . . cord-023095-4dannjjm 4175 1 VCR VCR NNP cord-023095-4dannjjm 4175 2 was be VBD cord-023095-4dannjjm 4175 3 higher high JJR cord-023095-4dannjjm 4175 4 ( ( -LRB- cord-023095-4dannjjm 4175 5 49.5[33.3 49.5[33.3 CD cord-023095-4dannjjm 4175 6 , , , cord-023095-4dannjjm 4175 7 74.1 74.1 CD cord-023095-4dannjjm 4175 8 ] ] -RRB- cord-023095-4dannjjm 4175 9 vs. vs. FW cord-023095-4dannjjm 4175 10 36.1[25.6 36.1[25.6 CD cord-023095-4dannjjm 4175 11 , , , cord-023095-4dannjjm 4175 12 42 42 CD cord-023095-4dannjjm 4175 13 .1 .1 CD cord-023095-4dannjjm 4175 14 ] ] -RRB- cord-023095-4dannjjm 4176 1 fg fg NNP cord-023095-4dannjjm 4176 2 / / SYM cord-023095-4dannjjm 4176 3 g g NNP cord-023095-4dannjjm 4176 4 , , , cord-023095-4dannjjm 4176 5 p p NN cord-023095-4dannjjm 4176 6 5 5 CD cord-023095-4dannjjm 4176 7 0.010 0.010 CD cord-023095-4dannjjm 4176 8 ) ) -RRB- cord-023095-4dannjjm 4176 9 in in IN cord-023095-4dannjjm 4176 10 untreated untreated JJ cord-023095-4dannjjm 4176 11 hypertensives hypertensive NNS cord-023095-4dannjjm 4176 12 ( ( -LRB- cord-023095-4dannjjm 4176 13 n n NN cord-023095-4dannjjm 4176 14 5 5 CD cord-023095-4dannjjm 4176 15 30 30 CD cord-023095-4dannjjm 4176 16 ) ) -RRB- cord-023095-4dannjjm 4176 17 than than IN cord-023095-4dannjjm 4176 18 normotensives normotensives NNP cord-023095-4dannjjm 4176 19 ( ( -LRB- cord-023095-4dannjjm 4176 20 n n NN cord-023095-4dannjjm 4176 21 5 5 CD cord-023095-4dannjjm 4176 22 63 63 CD cord-023095-4dannjjm 4176 23 ) ) -RRB- cord-023095-4dannjjm 4176 24 . . . cord-023095-4dannjjm 4177 1 VCR VCR NNP cord-023095-4dannjjm 4177 2 was be VBD cord-023095-4dannjjm 4177 3 correlated correlate VBN cord-023095-4dannjjm 4177 4 with with IN cord-023095-4dannjjm 4177 5 PCV PCV NNP cord-023095-4dannjjm 4177 6 ( ( -LRB- cord-023095-4dannjjm 4177 7 r r NNP cord-023095-4dannjjm 4177 8 5 5 CD cord-023095-4dannjjm 4177 9 À0.236 à0.236 CD cord-023095-4dannjjm 4177 10 , , , cord-023095-4dannjjm 4177 11 p p NN cord-023095-4dannjjm 4177 12 5 5 CD cord-023095-4dannjjm 4177 13 0.024 0.024 CD cord-023095-4dannjjm 4177 14 , , , cord-023095-4dannjjm 4177 15 n n NN cord-023095-4dannjjm 4177 16 5 5 CD cord-023095-4dannjjm 4177 17 92 92 CD cord-023095-4dannjjm 4177 18 ) ) -RRB- cord-023095-4dannjjm 4177 19 , , , cord-023095-4dannjjm 4177 20 UPC UPC NNP cord-023095-4dannjjm 4177 21 ( ( -LRB- cord-023095-4dannjjm 4177 22 r r NNP cord-023095-4dannjjm 4177 23 5 5 CD cord-023095-4dannjjm 4177 24 0.444 0.444 CD cord-023095-4dannjjm 4177 25 , , , cord-023095-4dannjjm 4177 26 p p NN cord-023095-4dannjjm 4177 27 o o NN cord-023095-4dannjjm 4177 28 0.001 0.001 CD cord-023095-4dannjjm 4177 29 , , , cord-023095-4dannjjm 4177 30 n n NN cord-023095-4dannjjm 4177 31 5 5 CD cord-023095-4dannjjm 4177 32 93 93 CD cord-023095-4dannjjm 4177 33 ) ) -RRB- cord-023095-4dannjjm 4177 34 , , , cord-023095-4dannjjm 4177 35 plasma plasma NN cord-023095-4dannjjm 4177 36 phosphate phosphate NN cord-023095-4dannjjm 4177 37 ( ( -LRB- cord-023095-4dannjjm 4178 1 r r LS cord-023095-4dannjjm 4178 2 5 5 CD cord-023095-4dannjjm 4178 3 0.286 0.286 CD cord-023095-4dannjjm 4178 4 , , , cord-023095-4dannjjm 4178 5 p p NN cord-023095-4dannjjm 4178 6 5 5 CD cord-023095-4dannjjm 4178 7 0.005 0.005 CD cord-023095-4dannjjm 4178 8 , , , cord-023095-4dannjjm 4178 9 n n NN cord-023095-4dannjjm 4178 10 5 5 CD cord-023095-4dannjjm 4178 11 93 93 CD cord-023095-4dannjjm 4178 12 ) ) -RRB- cord-023095-4dannjjm 4178 13 , , , cord-023095-4dannjjm 4178 14 and and CC cord-023095-4dannjjm 4178 15 USG USG NNP cord-023095-4dannjjm 4178 16 ( ( -LRB- cord-023095-4dannjjm 4178 17 r r NNP cord-023095-4dannjjm 4178 18 5 5 CD cord-023095-4dannjjm 4178 19 À0.284 à0.284 CD cord-023095-4dannjjm 4178 20 , , , cord-023095-4dannjjm 4178 21 p p NN cord-023095-4dannjjm 4178 22 5 5 CD cord-023095-4dannjjm 4178 23 0.006 0.006 CD cord-023095-4dannjjm 4178 24 , , , cord-023095-4dannjjm 4178 25 n n NN cord-023095-4dannjjm 4178 26 5 5 CD cord-023095-4dannjjm 4178 27 93 93 CD cord-023095-4dannjjm 4178 28 ) ) -RRB- cord-023095-4dannjjm 4178 29 , , , cord-023095-4dannjjm 4178 30 but but CC cord-023095-4dannjjm 4178 31 not not RB cord-023095-4dannjjm 4178 32 plasma plasma NN cord-023095-4dannjjm 4178 33 creatinine creatinine NN cord-023095-4dannjjm 4178 34 concentration concentration NN cord-023095-4dannjjm 4178 35 . . . cord-023095-4dannjjm 4179 1 In in IN cord-023095-4dannjjm 4179 2 the the DT cord-023095-4dannjjm 4179 3 best good JJS cord-023095-4dannjjm 4179 4 multivariate multivariate JJ cord-023095-4dannjjm 4179 5 model model NN cord-023095-4dannjjm 4179 6 , , , cord-023095-4dannjjm 4179 7 PCV PCV NNP cord-023095-4dannjjm 4179 8 was be VBD cord-023095-4dannjjm 4179 9 associated associate VBN cord-023095-4dannjjm 4179 10 with with IN cord-023095-4dannjjm 4179 11 VCR VCR NNP cord-023095-4dannjjm 4179 12 independently independently RB cord-023095-4dannjjm 4179 13 of of IN cord-023095-4dannjjm 4179 14 UPC UPC NNP cord-023095-4dannjjm 4179 15 ( ( -LRB- cord-023095-4dannjjm 4179 16 r r NN cord-023095-4dannjjm 4179 17 2 2 CD cord-023095-4dannjjm 4179 18 5 5 CD cord-023095-4dannjjm 4179 19 0.435 0.435 CD cord-023095-4dannjjm 4179 20 , , , cord-023095-4dannjjm 4179 21 n n NN cord-023095-4dannjjm 4179 22 5 5 CD cord-023095-4dannjjm 4179 23 92 92 CD cord-023095-4dannjjm 4179 24 ) ) -RRB- cord-023095-4dannjjm 4179 25 . . . cord-023095-4dannjjm 4180 1 VCR VCR NNP cord-023095-4dannjjm 4180 2 was be VBD cord-023095-4dannjjm 4180 3 significantly significantly RB cord-023095-4dannjjm 4180 4 reduced reduce VBN cord-023095-4dannjjm 4180 5 by by IN cord-023095-4dannjjm 4180 6 Benazepril Benazepril NNP cord-023095-4dannjjm 4180 7 therapy therapy NN cord-023095-4dannjjm 4180 8 ( ( -LRB- cord-023095-4dannjjm 4180 9 65.3 65.3 CD cord-023095-4dannjjm 4180 10 [ [ -LRB- cord-023095-4dannjjm 4180 11 43.1 43.1 CD cord-023095-4dannjjm 4180 12 , , , cord-023095-4dannjjm 4180 13 92 92 CD cord-023095-4dannjjm 4180 14 .7 .7 NFP cord-023095-4dannjjm 4180 15 ] ] -RRB- cord-023095-4dannjjm 4181 1 fg fg NNP cord-023095-4dannjjm 4181 2 / / SYM cord-023095-4dannjjm 4181 3 g g NN cord-023095-4dannjjm 4181 4 ) ) -RRB- cord-023095-4dannjjm 4182 1 compared compare VBN cord-023095-4dannjjm 4182 2 with with IN cord-023095-4dannjjm 4182 3 placebo placebo NN cord-023095-4dannjjm 4182 4 ( ( -LRB- cord-023095-4dannjjm 4182 5 76.0[48.0 76.0[48.0 CD cord-023095-4dannjjm 4182 6 , , , cord-023095-4dannjjm 4182 7 116.7 116.7 CD cord-023095-4dannjjm 4182 8 ] ] -RRB- cord-023095-4dannjjm 4182 9 fg fg NN cord-023095-4dannjjm 4182 10 / / SYM cord-023095-4dannjjm 4182 11 g g NN cord-023095-4dannjjm 4182 12 ; ; : cord-023095-4dannjjm 4182 13 p p NN cord-023095-4dannjjm 4182 14 5 5 CD cord-023095-4dannjjm 4182 15 0.031 0.031 CD cord-023095-4dannjjm 4182 16 , , , cord-023095-4dannjjm 4182 17 n n NN cord-023095-4dannjjm 4182 18 5 5 CD cord-023095-4dannjjm 4182 19 17 17 CD cord-023095-4dannjjm 4182 20 ) ) -RRB- cord-023095-4dannjjm 4182 21 with with IN cord-023095-4dannjjm 4182 22 a a DT cord-023095-4dannjjm 4182 23 reduction reduction NN cord-023095-4dannjjm 4182 24 seen see VBN cord-023095-4dannjjm 4182 25 in in IN cord-023095-4dannjjm 4182 26 76 76 CD cord-023095-4dannjjm 4182 27 % % NN cord-023095-4dannjjm 4182 28 of of IN cord-023095-4dannjjm 4182 29 cases case NNS cord-023095-4dannjjm 4182 30 . . . cord-023095-4dannjjm 4183 1 These these DT cord-023095-4dannjjm 4183 2 results result NNS cord-023095-4dannjjm 4183 3 suggest suggest VBP cord-023095-4dannjjm 4183 4 urinary urinary JJ cord-023095-4dannjjm 4183 5 VEGF vegf NN cord-023095-4dannjjm 4183 6 excretion excretion NN cord-023095-4dannjjm 4183 7 is be VBZ cord-023095-4dannjjm 4183 8 associated associate VBN cord-023095-4dannjjm 4183 9 with with IN cord-023095-4dannjjm 4183 10 proteinuria proteinuria NN cord-023095-4dannjjm 4183 11 in in IN cord-023095-4dannjjm 4183 12 cats cat NNS cord-023095-4dannjjm 4183 13 with with IN cord-023095-4dannjjm 4183 14 CKD CKD NNP cord-023095-4dannjjm 4183 15 and and CC cord-023095-4dannjjm 4183 16 might may MD cord-023095-4dannjjm 4183 17 be be VB cord-023095-4dannjjm 4183 18 a a DT cord-023095-4dannjjm 4183 19 marker marker NN cord-023095-4dannjjm 4183 20 of of IN cord-023095-4dannjjm 4183 21 renal renal JJ cord-023095-4dannjjm 4183 22 hypoxia hypoxia NN cord-023095-4dannjjm 4183 23 induced induce VBN cord-023095-4dannjjm 4183 24 by by IN cord-023095-4dannjjm 4183 25 low low JJ cord-023095-4dannjjm 4183 26 PCV pcv NN cord-023095-4dannjjm 4183 27 . . . cord-023095-4dannjjm 4184 1 ACE ace NN cord-023095-4dannjjm 4184 2 inhibitor inhibitor NN cord-023095-4dannjjm 4184 3 therapy therapy NN cord-023095-4dannjjm 4184 4 might may MD cord-023095-4dannjjm 4184 5 reduce reduce VB cord-023095-4dannjjm 4184 6 urinary urinary JJ cord-023095-4dannjjm 4184 7 VEGF vegf NN cord-023095-4dannjjm 4184 8 excretion excretion NN cord-023095-4dannjjm 4184 9 because because IN cord-023095-4dannjjm 4184 10 angiotensin angiotensin NN cord-023095-4dannjjm 4184 11 II II NNP cord-023095-4dannjjm 4184 12 causes cause VBZ cord-023095-4dannjjm 4184 13 constriction constriction NN cord-023095-4dannjjm 4184 14 on on IN cord-023095-4dannjjm 4184 15 efferent efferent JJ cord-023095-4dannjjm 4184 16 arterioles arteriole NNS cord-023095-4dannjjm 4184 17 resulting result VBG cord-023095-4dannjjm 4184 18 in in IN cord-023095-4dannjjm 4184 19 tubular tubular JJ cord-023095-4dannjjm 4184 20 hypoxia hypoxia NN cord-023095-4dannjjm 4184 21 . . . cord-023095-4dannjjm 4185 1 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4185 2 is be VBZ cord-023095-4dannjjm 4185 3 a a DT cord-023095-4dannjjm 4185 4 phosphaturic phosphaturic JJ cord-023095-4dannjjm 4185 5 hormone hormone NN cord-023095-4dannjjm 4185 6 . . . cord-023095-4dannjjm 4186 1 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4186 2 concentrations concentration NNS cord-023095-4dannjjm 4186 3 increase increase VBP cord-023095-4dannjjm 4186 4 with with IN cord-023095-4dannjjm 4186 5 declining decline VBG cord-023095-4dannjjm 4186 6 renal renal JJ cord-023095-4dannjjm 4186 7 function function NN cord-023095-4dannjjm 4186 8 in in IN cord-023095-4dannjjm 4186 9 humans human NNS cord-023095-4dannjjm 4186 10 . . . cord-023095-4dannjjm 4187 1 The the DT cord-023095-4dannjjm 4187 2 objectives objective NNS cord-023095-4dannjjm 4187 3 of of IN cord-023095-4dannjjm 4187 4 this this DT cord-023095-4dannjjm 4187 5 study study NN cord-023095-4dannjjm 4187 6 were be VBD cord-023095-4dannjjm 4187 7 to to TO cord-023095-4dannjjm 4187 8 validate validate VB cord-023095-4dannjjm 4187 9 a a DT cord-023095-4dannjjm 4187 10 method method NN cord-023095-4dannjjm 4187 11 for for IN cord-023095-4dannjjm 4187 12 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4187 13 quantification quantification NN cord-023095-4dannjjm 4187 14 in in IN cord-023095-4dannjjm 4187 15 feline feline JJ cord-023095-4dannjjm 4187 16 plasma plasma NN cord-023095-4dannjjm 4187 17 and and CC cord-023095-4dannjjm 4187 18 to to TO cord-023095-4dannjjm 4187 19 assess assess VB cord-023095-4dannjjm 4187 20 the the DT cord-023095-4dannjjm 4187 21 association association NN cord-023095-4dannjjm 4187 22 between between IN cord-023095-4dannjjm 4187 23 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4187 24 concentration concentration NN cord-023095-4dannjjm 4187 25 and and CC cord-023095-4dannjjm 4187 26 plasma plasma NN cord-023095-4dannjjm 4187 27 creatinine creatinine NN cord-023095-4dannjjm 4187 28 or or CC cord-023095-4dannjjm 4187 29 phosphate phosphate NN cord-023095-4dannjjm 4187 30 concentration concentration NN cord-023095-4dannjjm 4187 31 in in IN cord-023095-4dannjjm 4187 32 cats cat NNS cord-023095-4dannjjm 4187 33 with with IN cord-023095-4dannjjm 4187 34 chronic chronic JJ cord-023095-4dannjjm 4187 35 kidney kidney NN cord-023095-4dannjjm 4187 36 disease disease NN cord-023095-4dannjjm 4187 37 ( ( -LRB- cord-023095-4dannjjm 4187 38 CKD CKD NNP cord-023095-4dannjjm 4187 39 ) ) -RRB- cord-023095-4dannjjm 4187 40 . . . cord-023095-4dannjjm 4188 1 Non non JJ cord-023095-4dannjjm 4188 2 - - NN cord-023095-4dannjjm 4188 3 azotemic azotemic JJ cord-023095-4dannjjm 4188 4 and and CC cord-023095-4dannjjm 4188 5 azotemic azotemic NNP cord-023095-4dannjjm 4188 6 ( ( -LRB- cord-023095-4dannjjm 4188 7 plasma plasma NN cord-023095-4dannjjm 4188 8 creatinine creatinine NN cord-023095-4dannjjm 4188 9 concentration concentration NN cord-023095-4dannjjm 4188 10 ( ( -LRB- cord-023095-4dannjjm 4188 11 Cr Cr NNP cord-023095-4dannjjm 4188 12 ) ) -RRB- cord-023095-4dannjjm 4188 13 4 4 CD cord-023095-4dannjjm 4188 14 2.0 2.0 CD cord-023095-4dannjjm 4188 15 mg mg NNP cord-023095-4dannjjm 4188 16 / / SYM cord-023095-4dannjjm 4188 17 dl dl NN cord-023095-4dannjjm 4188 18 ) ) -RRB- cord-023095-4dannjjm 4188 19 geriatric geriatric NNP cord-023095-4dannjjm 4188 20 ( ( -LRB- cord-023095-4dannjjm 4188 21 4 4 CD cord-023095-4dannjjm 4188 22 9yrs 9yrs CD cord-023095-4dannjjm 4188 23 ) ) -RRB- cord-023095-4dannjjm 4189 1 cats cat NNS cord-023095-4dannjjm 4189 2 were be VBD cord-023095-4dannjjm 4189 3 recruited recruit VBN cord-023095-4dannjjm 4189 4 into into IN cord-023095-4dannjjm 4189 5 the the DT cord-023095-4dannjjm 4189 6 cross cross JJ cord-023095-4dannjjm 4189 7 - - JJ cord-023095-4dannjjm 4189 8 sectional sectional JJ cord-023095-4dannjjm 4189 9 study study NN cord-023095-4dannjjm 4189 10 from from IN cord-023095-4dannjjm 4189 11 two two CD cord-023095-4dannjjm 4189 12 London London NNP cord-023095-4dannjjm 4189 13 first first JJ cord-023095-4dannjjm 4189 14 opinion opinion NN cord-023095-4dannjjm 4189 15 practices practice NNS cord-023095-4dannjjm 4189 16 . . . cord-023095-4dannjjm 4190 1 Cats cat NNS cord-023095-4dannjjm 4190 2 were be VBD cord-023095-4dannjjm 4190 3 excluded exclude VBN cord-023095-4dannjjm 4190 4 from from IN cord-023095-4dannjjm 4190 5 the the DT cord-023095-4dannjjm 4190 6 study study NN cord-023095-4dannjjm 4190 7 if if IN cord-023095-4dannjjm 4190 8 they -PRON- PRP cord-023095-4dannjjm 4190 9 were be VBD cord-023095-4dannjjm 4190 10 fed feed VBN cord-023095-4dannjjm 4190 11 a a DT cord-023095-4dannjjm 4190 12 phosphate phosphate NN cord-023095-4dannjjm 4190 13 restricted restrict VBN cord-023095-4dannjjm 4190 14 diet diet NN cord-023095-4dannjjm 4190 15 , , , cord-023095-4dannjjm 4190 16 or or CC cord-023095-4dannjjm 4190 17 had have VBD cord-023095-4dannjjm 4190 18 evidence evidence NN cord-023095-4dannjjm 4190 19 of of IN cord-023095-4dannjjm 4190 20 concurrent concurrent JJ cord-023095-4dannjjm 4190 21 disease disease NN cord-023095-4dannjjm 4190 22 . . . cord-023095-4dannjjm 4191 1 The the DT cord-023095-4dannjjm 4191 2 cats cat NNS cord-023095-4dannjjm 4191 3 were be VBD cord-023095-4dannjjm 4191 4 categorized categorize VBN cord-023095-4dannjjm 4191 5 , , , cord-023095-4dannjjm 4191 6 using use VBG cord-023095-4dannjjm 4191 7 a a DT cord-023095-4dannjjm 4191 8 modified modify VBN cord-023095-4dannjjm 4191 9 IRIS IRIS NNP cord-023095-4dannjjm 4191 10 staging stage VBG cord-023095-4dannjjm 4191 11 system system NN cord-023095-4dannjjm 4191 12 , , , cord-023095-4dannjjm 4191 13 into into IN cord-023095-4dannjjm 4191 14 the the DT cord-023095-4dannjjm 4191 15 following follow VBG cord-023095-4dannjjm 4191 16 four four CD cord-023095-4dannjjm 4191 17 groups group NNS cord-023095-4dannjjm 4191 18 : : : cord-023095-4dannjjm 4191 19 group group NN cord-023095-4dannjjm 4191 20 1 1 CD cord-023095-4dannjjm 4191 21 ( ( -LRB- cord-023095-4dannjjm 4191 22 Cr Cr NNP cord-023095-4dannjjm 4191 23 1.6 1.6 CD cord-023095-4dannjjm 4191 24 mg mg NNP cord-023095-4dannjjm 4191 25 / / SYM cord-023095-4dannjjm 4191 26 dl dl NNP cord-023095-4dannjjm 4191 27 ) ) -RRB- cord-023095-4dannjjm 4191 28 , , , cord-023095-4dannjjm 4191 29 group group NN cord-023095-4dannjjm 4191 30 2 2 CD cord-023095-4dannjjm 4192 1 ( ( -LRB- cord-023095-4dannjjm 4192 2 Cr Cr NNP cord-023095-4dannjjm 4192 3 2.0 2.0 CD cord-023095-4dannjjm 4192 4 - - HYPH cord-023095-4dannjjm 4192 5 2.8 2.8 CD cord-023095-4dannjjm 4192 6 mg mg NNP cord-023095-4dannjjm 4192 7 / / SYM cord-023095-4dannjjm 4192 8 dl dl NNP cord-023095-4dannjjm 4192 9 ) ) -RRB- cord-023095-4dannjjm 4192 10 , , , cord-023095-4dannjjm 4192 11 group group NN cord-023095-4dannjjm 4192 12 3 3 CD cord-023095-4dannjjm 4193 1 ( ( -LRB- cord-023095-4dannjjm 4193 2 Cr Cr NNP cord-023095-4dannjjm 4193 3 2.9 2.9 CD cord-023095-4dannjjm 4193 4 - - HYPH cord-023095-4dannjjm 4193 5 5.0 5.0 CD cord-023095-4dannjjm 4193 6 mg mg NNP cord-023095-4dannjjm 4193 7 / / SYM cord-023095-4dannjjm 4193 8 dl dl NNP cord-023095-4dannjjm 4193 9 ) ) -RRB- cord-023095-4dannjjm 4193 10 , , , cord-023095-4dannjjm 4193 11 group group NN cord-023095-4dannjjm 4193 12 4 4 CD cord-023095-4dannjjm 4194 1 ( ( -LRB- cord-023095-4dannjjm 4194 2 Cr Cr NNP cord-023095-4dannjjm 4194 3 4 4 CD cord-023095-4dannjjm 4194 4 5.0 5.0 CD cord-023095-4dannjjm 4194 5 mg mg NNP cord-023095-4dannjjm 4194 6 / / SYM cord-023095-4dannjjm 4194 7 dl dl NN cord-023095-4dannjjm 4194 8 ) ) -RRB- cord-023095-4dannjjm 4194 9 . . . cord-023095-4dannjjm 4195 1 Groups group NNS cord-023095-4dannjjm 4195 2 2 2 CD cord-023095-4dannjjm 4195 3 and and CC cord-023095-4dannjjm 4195 4 3 3 CD cord-023095-4dannjjm 4195 5 were be VBD cord-023095-4dannjjm 4195 6 further further RB cord-023095-4dannjjm 4195 7 subdivided subdivide VBN cord-023095-4dannjjm 4195 8 based base VBN cord-023095-4dannjjm 4195 9 on on IN cord-023095-4dannjjm 4195 10 the the DT cord-023095-4dannjjm 4195 11 IRIS IRIS NNP cord-023095-4dannjjm 4195 12 targets target NNS cord-023095-4dannjjm 4195 13 for for IN cord-023095-4dannjjm 4195 14 plasma plasma NN cord-023095-4dannjjm 4195 15 phosphate phosphate NN cord-023095-4dannjjm 4195 16 concentration concentration NN cord-023095-4dannjjm 4195 17 ( ( -LRB- cord-023095-4dannjjm 4196 1 PO PO NNP cord-023095-4dannjjm 4196 2 4 4 CD cord-023095-4dannjjm 4196 3 ): ): NNP cord-023095-4dannjjm 4196 4 group group NNP cord-023095-4dannjjm 4196 5 2a 2a CD cord-023095-4dannjjm 4197 1 ( ( -LRB- cord-023095-4dannjjm 4197 2 PO PO NNP cord-023095-4dannjjm 4197 3 4 4 CD cord-023095-4dannjjm 4197 4 4.5 4.5 CD cord-023095-4dannjjm 4197 5 mg mg NNP cord-023095-4dannjjm 4197 6 / / SYM cord-023095-4dannjjm 4197 7 dl dl NNP cord-023095-4dannjjm 4197 8 ) ) -RRB- cord-023095-4dannjjm 4197 9 , , , cord-023095-4dannjjm 4197 10 group group NN cord-023095-4dannjjm 4197 11 2b 2b NNP cord-023095-4dannjjm 4198 1 ( ( -LRB- cord-023095-4dannjjm 4198 2 PO PO NNP cord-023095-4dannjjm 4198 3 4 4 CD cord-023095-4dannjjm 4198 4 4 4 CD cord-023095-4dannjjm 4198 5 4.5 4.5 CD cord-023095-4dannjjm 4198 6 mg mg NNP cord-023095-4dannjjm 4198 7 / / SYM cord-023095-4dannjjm 4198 8 dl dl NNP cord-023095-4dannjjm 4198 9 ) ) -RRB- cord-023095-4dannjjm 4198 10 , , , cord-023095-4dannjjm 4198 11 group group NN cord-023095-4dannjjm 4198 12 3a 3a NNP cord-023095-4dannjjm 4198 13 ( ( -LRB- cord-023095-4dannjjm 4198 14 PO PO NNP cord-023095-4dannjjm 4198 15 4 4 CD cord-023095-4dannjjm 4198 16 5 5 CD cord-023095-4dannjjm 4198 17 mg mg NNP cord-023095-4dannjjm 4198 18 / / SYM cord-023095-4dannjjm 4198 19 dl dl NNP cord-023095-4dannjjm 4198 20 ) ) -RRB- cord-023095-4dannjjm 4198 21 , , , cord-023095-4dannjjm 4198 22 group group NN cord-023095-4dannjjm 4198 23 3b 3b CD cord-023095-4dannjjm 4198 24 ( ( -LRB- cord-023095-4dannjjm 4198 25 PO PO NNP cord-023095-4dannjjm 4198 26 4 4 CD cord-023095-4dannjjm 4199 1 4 4 CD cord-023095-4dannjjm 4199 2 5 5 CD cord-023095-4dannjjm 4199 3 mg mg NNP cord-023095-4dannjjm 4199 4 / / SYM cord-023095-4dannjjm 4199 5 dl dl NNP cord-023095-4dannjjm 4199 6 ) ) -RRB- cord-023095-4dannjjm 4199 7 . . . cord-023095-4dannjjm 4200 1 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4200 2 concentrations concentration NNS cord-023095-4dannjjm 4200 3 were be VBD cord-023095-4dannjjm 4200 4 measured measure VBN cord-023095-4dannjjm 4200 5 in in IN cord-023095-4dannjjm 4200 6 feline feline JJ cord-023095-4dannjjm 4200 7 EDTA edta NN cord-023095-4dannjjm 4200 8 plasma plasma NN cord-023095-4dannjjm 4200 9 using use VBG cord-023095-4dannjjm 4200 10 a a DT cord-023095-4dannjjm 4200 11 human human JJ cord-023095-4dannjjm 4200 12 intact intact JJ cord-023095-4dannjjm 4200 13 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4200 14 ELISA ELISA NNP cord-023095-4dannjjm 4200 15 , , , cord-023095-4dannjjm 4200 16 validated validate VBN cord-023095-4dannjjm 4200 17 by by IN cord-023095-4dannjjm 4200 18 intraand intraand NNP cord-023095-4dannjjm 4200 19 inter inter JJ cord-023095-4dannjjm 4200 20 - - JJ cord-023095-4dannjjm 4200 21 assay assay JJ cord-023095-4dannjjm 4200 22 variability variability NN cord-023095-4dannjjm 4200 23 and and CC cord-023095-4dannjjm 4200 24 assessment assessment NN cord-023095-4dannjjm 4200 25 of of IN cord-023095-4dannjjm 4200 26 dilutional dilutional JJ cord-023095-4dannjjm 4200 27 parallelism parallelism NN cord-023095-4dannjjm 4200 28 . . . cord-023095-4dannjjm 4201 1 Comparisons comparison NNS cord-023095-4dannjjm 4201 2 between between IN cord-023095-4dannjjm 4201 3 groups group NNS cord-023095-4dannjjm 4201 4 were be VBD cord-023095-4dannjjm 4201 5 made make VBN cord-023095-4dannjjm 4201 6 using use VBG cord-023095-4dannjjm 4201 7 the the DT cord-023095-4dannjjm 4201 8 Kruskal Kruskal NNP cord-023095-4dannjjm 4201 9 - - HYPH cord-023095-4dannjjm 4201 10 Wallis Wallis NNP cord-023095-4dannjjm 4201 11 test test NN cord-023095-4dannjjm 4201 12 and and CC cord-023095-4dannjjm 4202 1 Mann Mann NNP cord-023095-4dannjjm 4202 2 - - HYPH cord-023095-4dannjjm 4202 3 Whitney Whitney NNP cord-023095-4dannjjm 4202 4 U U NNP cord-023095-4dannjjm 4202 5 test test NN cord-023095-4dannjjm 4202 6 , , , cord-023095-4dannjjm 4202 7 with with IN cord-023095-4dannjjm 4202 8 statistical statistical JJ cord-023095-4dannjjm 4202 9 significance significance NN cord-023095-4dannjjm 4202 10 defined define VBN cord-023095-4dannjjm 4202 11 as as IN cord-023095-4dannjjm 4202 12 P p NN cord-023095-4dannjjm 4202 13 o o NN cord-023095-4dannjjm 4202 14 0.05 0.05 CD cord-023095-4dannjjm 4202 15 . . . cord-023095-4dannjjm 4203 1 Bonferroni bonferroni JJ cord-023095-4dannjjm 4203 2 correction correction NN cord-023095-4dannjjm 4203 3 was be VBD cord-023095-4dannjjm 4203 4 applied apply VBN cord-023095-4dannjjm 4203 5 where where WRB cord-023095-4dannjjm 4203 6 appropriate appropriate JJ cord-023095-4dannjjm 4203 7 ( ( -LRB- cord-023095-4dannjjm 4203 8 statistical statistical JJ cord-023095-4dannjjm 4203 9 significance significance NN cord-023095-4dannjjm 4203 10 then then RB cord-023095-4dannjjm 4203 11 determined determine VBD cord-023095-4dannjjm 4203 12 as as IN cord-023095-4dannjjm 4203 13 P p NN cord-023095-4dannjjm 4203 14 o o NN cord-023095-4dannjjm 4203 15 0.008 0.008 CD cord-023095-4dannjjm 4203 16 ) ) -RRB- cord-023095-4dannjjm 4203 17 . . . cord-023095-4dannjjm 4204 1 Results result NNS cord-023095-4dannjjm 4204 2 are be VBP cord-023095-4dannjjm 4204 3 reported report VBN cord-023095-4dannjjm 4204 4 as as IN cord-023095-4dannjjm 4204 5 median median JJ cord-023095-4dannjjm 4204 6 [ [ -LRB- cord-023095-4dannjjm 4204 7 25th 25th NN cord-023095-4dannjjm 4204 8 , , , cord-023095-4dannjjm 4204 9 75th 75th JJ cord-023095-4dannjjm 4204 10 percentiles percentile NNS cord-023095-4dannjjm 4204 11 ] ] -RRB- cord-023095-4dannjjm 4204 12 . . . cord-023095-4dannjjm 4205 1 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4205 2 concentrations concentration NNS cord-023095-4dannjjm 4205 3 ! ! . cord-023095-4dannjjm 4206 1 800pg 800pg NNP cord-023095-4dannjjm 4206 2 / / SYM cord-023095-4dannjjm 4206 3 ml ml NN cord-023095-4dannjjm 4206 4 ( ( -LRB- cord-023095-4dannjjm 4206 5 upper upper JJ cord-023095-4dannjjm 4206 6 limit limit NN cord-023095-4dannjjm 4206 7 of of IN cord-023095-4dannjjm 4206 8 quantification quantification NN cord-023095-4dannjjm 4206 9 ) ) -RRB- cord-023095-4dannjjm 4206 10 were be VBD cord-023095-4dannjjm 4206 11 assigned assign VBN cord-023095-4dannjjm 4206 12 the the DT cord-023095-4dannjjm 4206 13 value value NN cord-023095-4dannjjm 4206 14 of of IN cord-023095-4dannjjm 4206 15 800pg 800pg NNP cord-023095-4dannjjm 4206 16 / / SYM cord-023095-4dannjjm 4206 17 ml ml NN cord-023095-4dannjjm 4206 18 . . . cord-023095-4dannjjm 4207 1 Intra Intra NNP cord-023095-4dannjjm 4207 2 - - : cord-023095-4dannjjm 4207 3 and and CC cord-023095-4dannjjm 4207 4 inter inter JJ cord-023095-4dannjjm 4207 5 - - JJ cord-023095-4dannjjm 4207 6 assay assay JJ cord-023095-4dannjjm 4207 7 variability variability NN cord-023095-4dannjjm 4207 8 of of IN cord-023095-4dannjjm 4207 9 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4207 10 measurements measurement NNS cord-023095-4dannjjm 4207 11 were be VBD cord-023095-4dannjjm 4207 12 o o NN cord-023095-4dannjjm 4207 13 10.0 10.0 CD cord-023095-4dannjjm 4207 14 % % NN cord-023095-4dannjjm 4207 15 and and CC cord-023095-4dannjjm 4207 16 dilutional dilutional JJ cord-023095-4dannjjm 4207 17 parallelism parallelism NN cord-023095-4dannjjm 4207 18 between between IN cord-023095-4dannjjm 4207 19 feline feline JJ cord-023095-4dannjjm 4207 20 samples sample NNS cord-023095-4dannjjm 4207 21 and and CC cord-023095-4dannjjm 4207 22 the the DT cord-023095-4dannjjm 4207 23 calibration calibration NN cord-023095-4dannjjm 4207 24 curve curve NN cord-023095-4dannjjm 4207 25 were be VBD cord-023095-4dannjjm 4207 26 demonstrated demonstrate VBN cord-023095-4dannjjm 4207 27 . . . cord-023095-4dannjjm 4208 1 Plasma plasma NN cord-023095-4dannjjm 4208 2 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4208 3 concentrations concentration NNS cord-023095-4dannjjm 4208 4 increased increase VBD cord-023095-4dannjjm 4208 5 with with IN cord-023095-4dannjjm 4208 6 increasing increase VBG cord-023095-4dannjjm 4208 7 creatinine creatinine NN cord-023095-4dannjjm 4208 8 concentrations concentration NNS cord-023095-4dannjjm 4208 9 ( ( -LRB- cord-023095-4dannjjm 4208 10 group group NN cord-023095-4dannjjm 4208 11 1 1 CD cord-023095-4dannjjm 4208 12 : : : cord-023095-4dannjjm 4208 13 158 158 CD cord-023095-4dannjjm 4208 14 [ [ -LRB- cord-023095-4dannjjm 4208 15 115 115 CD cord-023095-4dannjjm 4208 16 , , , cord-023095-4dannjjm 4208 17 274 274 CD cord-023095-4dannjjm 4208 18 ] ] -RRB- cord-023095-4dannjjm 4208 19 , , , cord-023095-4dannjjm 4208 20 n n NN cord-023095-4dannjjm 4208 21 5 5 CD cord-023095-4dannjjm 4208 22 20 20 CD cord-023095-4dannjjm 4208 23 , , , cord-023095-4dannjjm 4208 24 group group NN cord-023095-4dannjjm 4208 25 2 2 CD cord-023095-4dannjjm 4208 26 : : : cord-023095-4dannjjm 4208 27 354 354 CD cord-023095-4dannjjm 4208 28 [ [ -LRB- cord-023095-4dannjjm 4208 29 239 239 CD cord-023095-4dannjjm 4208 30 , , , cord-023095-4dannjjm 4208 31 473 473 CD cord-023095-4dannjjm 4208 32 ] ] -RRB- cord-023095-4dannjjm 4208 33 , , , cord-023095-4dannjjm 4208 34 n n NN cord-023095-4dannjjm 4208 35 5 5 CD cord-023095-4dannjjm 4208 36 20 20 CD cord-023095-4dannjjm 4208 37 , , , cord-023095-4dannjjm 4208 38 group group NN cord-023095-4dannjjm 4208 39 3 3 CD cord-023095-4dannjjm 4208 40 : : : cord-023095-4dannjjm 4208 41 800 800 CD cord-023095-4dannjjm 4208 42 [ [ -LRB- cord-023095-4dannjjm 4208 43 425 425 CD cord-023095-4dannjjm 4208 44 , , , cord-023095-4dannjjm 4208 45 800 800 CD cord-023095-4dannjjm 4208 46 ] ] -RRB- cord-023095-4dannjjm 4208 47 , , , cord-023095-4dannjjm 4208 48 n n NN cord-023095-4dannjjm 4208 49 5 5 CD cord-023095-4dannjjm 4208 50 23 23 CD cord-023095-4dannjjm 4208 51 , , , cord-023095-4dannjjm 4208 52 group group NN cord-023095-4dannjjm 4208 53 4 4 CD cord-023095-4dannjjm 4208 54 : : : cord-023095-4dannjjm 4208 55 800 800 CD cord-023095-4dannjjm 4208 56 [ [ -LRB- cord-023095-4dannjjm 4208 57 800 800 CD cord-023095-4dannjjm 4208 58 , , , cord-023095-4dannjjm 4208 59 800 800 CD cord-023095-4dannjjm 4208 60 ] ] -RRB- cord-023095-4dannjjm 4208 61 , , , cord-023095-4dannjjm 4208 62 n n NN cord-023095-4dannjjm 4208 63 5 5 CD cord-023095-4dannjjm 4208 64 14 14 CD cord-023095-4dannjjm 4208 65 ) ) -RRB- cord-023095-4dannjjm 4208 66 . . . cord-023095-4dannjjm 4209 1 FGF-23 fgf-23 JJ cord-023095-4dannjjm 4209 2 measurements measurement NNS cord-023095-4dannjjm 4209 3 were be VBD cord-023095-4dannjjm 4209 4 significantly significantly RB cord-023095-4dannjjm 4209 5 different different JJ cord-023095-4dannjjm 4209 6 between between IN cord-023095-4dannjjm 4209 7 all all DT cord-023095-4dannjjm 4209 8 groups group NNS cord-023095-4dannjjm 4209 9 ( ( -LRB- cord-023095-4dannjjm 4209 10 P p NN cord-023095-4dannjjm 4209 11 5 5 CD cord-023095-4dannjjm 4209 12 0.005 0.005 CD cord-023095-4dannjjm 4209 13 to to IN cord-023095-4dannjjm 4209 14 o o CD cord-023095-4dannjjm 4209 15 0.001 0.001 CD cord-023095-4dannjjm 4209 16 ) ) -RRB- cord-023095-4dannjjm 4209 17 except except IN cord-023095-4dannjjm 4209 18 between between IN cord-023095-4dannjjm 4209 19 groups group NNS cord-023095-4dannjjm 4209 20 2 2 CD cord-023095-4dannjjm 4209 21 and and CC cord-023095-4dannjjm 4209 22 3 3 CD cord-023095-4dannjjm 4210 1 ( ( -LRB- cord-023095-4dannjjm 4210 2 P p NN cord-023095-4dannjjm 4210 3 5 5 CD cord-023095-4dannjjm 4210 4 0.01 0.01 CD cord-023095-4dannjjm 4210 5 ) ) -RRB- cord-023095-4dannjjm 4210 6 . . . cord-023095-4dannjjm 4211 1 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4211 2 concentrations concentration NNS cord-023095-4dannjjm 4211 3 were be VBD cord-023095-4dannjjm 4211 4 significantly significantly RB cord-023095-4dannjjm 4211 5 higher high JJR cord-023095-4dannjjm 4211 6 in in IN cord-023095-4dannjjm 4211 7 cats cat NNS cord-023095-4dannjjm 4211 8 with with IN cord-023095-4dannjjm 4211 9 higher high JJR cord-023095-4dannjjm 4211 10 plasma plasma NN cord-023095-4dannjjm 4211 11 phosphate phosphate NN cord-023095-4dannjjm 4211 12 concentrations concentration NNS cord-023095-4dannjjm 4211 13 ( ( -LRB- cord-023095-4dannjjm 4211 14 group group NN cord-023095-4dannjjm 4211 15 2a 2a CD cord-023095-4dannjjm 4211 16 : : : cord-023095-4dannjjm 4211 17 329 329 CD cord-023095-4dannjjm 4211 18 [ [ -LRB- cord-023095-4dannjjm 4211 19 237 237 CD cord-023095-4dannjjm 4211 20 , , , cord-023095-4dannjjm 4211 21 423 423 CD cord-023095-4dannjjm 4211 22 ] ] -RRB- cord-023095-4dannjjm 4211 23 , , , cord-023095-4dannjjm 4211 24 n n NN cord-023095-4dannjjm 4211 25 5 5 CD cord-023095-4dannjjm 4211 26 16 16 CD cord-023095-4dannjjm 4211 27 vs. vs. IN cord-023095-4dannjjm 4211 28 group group NN cord-023095-4dannjjm 4211 29 2b 2b CD cord-023095-4dannjjm 4211 30 : : : cord-023095-4dannjjm 4211 31 576 576 CD cord-023095-4dannjjm 4211 32 [ [ -LRB- cord-023095-4dannjjm 4211 33 374 374 CD cord-023095-4dannjjm 4211 34 , , , cord-023095-4dannjjm 4211 35 793 793 CD cord-023095-4dannjjm 4211 36 ] ] -RRB- cord-023095-4dannjjm 4211 37 , , , cord-023095-4dannjjm 4211 38 n n NN cord-023095-4dannjjm 4211 39 5 5 CD cord-023095-4dannjjm 4211 40 4 4 CD cord-023095-4dannjjm 4211 41 ; ; : cord-023095-4dannjjm 4211 42 P p NN cord-023095-4dannjjm 4211 43 5 5 CD cord-023095-4dannjjm 4211 44 0.047 0.047 CD cord-023095-4dannjjm 4211 45 ) ) -RRB- cord-023095-4dannjjm 4211 46 and and CC cord-023095-4dannjjm 4211 47 ( ( -LRB- cord-023095-4dannjjm 4211 48 group group NN cord-023095-4dannjjm 4211 49 3a 3a NNP cord-023095-4dannjjm 4211 50 : : : cord-023095-4dannjjm 4211 51 432 432 CD cord-023095-4dannjjm 4211 52 [ [ -LRB- cord-023095-4dannjjm 4211 53 167 167 CD cord-023095-4dannjjm 4211 54 , , , cord-023095-4dannjjm 4211 55 800 800 CD cord-023095-4dannjjm 4211 56 ] ] -RRB- cord-023095-4dannjjm 4211 57 , , , cord-023095-4dannjjm 4211 58 n n NN cord-023095-4dannjjm 4211 59 5 5 CD cord-023095-4dannjjm 4211 60 10 10 CD cord-023095-4dannjjm 4211 61 vs. vs. IN cord-023095-4dannjjm 4211 62 group group NN cord-023095-4dannjjm 4211 63 3b 3b CD cord-023095-4dannjjm 4211 64 : : : cord-023095-4dannjjm 4211 65 800 800 CD cord-023095-4dannjjm 4211 66 [ [ -LRB- cord-023095-4dannjjm 4211 67 625 625 CD cord-023095-4dannjjm 4211 68 , , , cord-023095-4dannjjm 4211 69 800 800 CD cord-023095-4dannjjm 4211 70 ] ] -RRB- cord-023095-4dannjjm 4211 71 , , , cord-023095-4dannjjm 4211 72 n n NN cord-023095-4dannjjm 4211 73 5 5 CD cord-023095-4dannjjm 4211 74 13 13 CD cord-023095-4dannjjm 4211 75 ; ; : cord-023095-4dannjjm 4211 76 P p NN cord-023095-4dannjjm 4211 77 5 5 CD cord-023095-4dannjjm 4211 78 0.028 0.028 CD cord-023095-4dannjjm 4211 79 ) ) -RRB- cord-023095-4dannjjm 4211 80 . . . cord-023095-4dannjjm 4212 1 In in IN cord-023095-4dannjjm 4212 2 conclusion conclusion NN cord-023095-4dannjjm 4212 3 , , , cord-023095-4dannjjm 4212 4 FGF-23 FGF-23 NNP cord-023095-4dannjjm 4212 5 concentrations concentration NNS cord-023095-4dannjjm 4212 6 were be VBD cord-023095-4dannjjm 4212 7 higher high JJR cord-023095-4dannjjm 4212 8 in in IN cord-023095-4dannjjm 4212 9 cats cat NNS cord-023095-4dannjjm 4212 10 with with IN cord-023095-4dannjjm 4212 11 more more RBR cord-023095-4dannjjm 4212 12 severe severe JJ cord-023095-4dannjjm 4212 13 CKD CKD NNP cord-023095-4dannjjm 4212 14 or or CC cord-023095-4dannjjm 4212 15 higher high JJR cord-023095-4dannjjm 4212 16 plasma plasma NN cord-023095-4dannjjm 4212 17 phosphate phosphate NN cord-023095-4dannjjm 4212 18 concentrations concentration NNS cord-023095-4dannjjm 4212 19 as as IN cord-023095-4dannjjm 4212 20 would would MD cord-023095-4dannjjm 4212 21 be be VB cord-023095-4dannjjm 4212 22 predicted predict VBN cord-023095-4dannjjm 4212 23 from from IN cord-023095-4dannjjm 4212 24 its -PRON- PRP$ cord-023095-4dannjjm 4212 25 known know VBN cord-023095-4dannjjm 4212 26 biological biological JJ cord-023095-4dannjjm 4212 27 actions action NNS cord-023095-4dannjjm 4212 28 . . . cord-023095-4dannjjm 4213 1 Further further JJ cord-023095-4dannjjm 4213 2 work work NN cord-023095-4dannjjm 4213 3 is be VBZ cord-023095-4dannjjm 4213 4 warranted warrant VBN cord-023095-4dannjjm 4213 5 to to TO cord-023095-4dannjjm 4213 6 explore explore VB cord-023095-4dannjjm 4213 7 the the DT cord-023095-4dannjjm 4213 8 role role NN cord-023095-4dannjjm 4213 9 of of IN cord-023095-4dannjjm 4213 10 FGF-23 FGF-23 NNPS cord-023095-4dannjjm 4213 11 in in IN cord-023095-4dannjjm 4213 12 the the DT cord-023095-4dannjjm 4213 13 development development NN cord-023095-4dannjjm 4213 14 of of IN cord-023095-4dannjjm 4213 15 renal renal JJ cord-023095-4dannjjm 4213 16 secondary secondary JJ cord-023095-4dannjjm 4213 17 hyperparathyroidism hyperparathyroidism NN cord-023095-4dannjjm 4213 18 by by IN cord-023095-4dannjjm 4213 19 measuring measure VBG cord-023095-4dannjjm 4213 20 parathyroid parathyroid JJ cord-023095-4dannjjm 4213 21 hormone hormone NN cord-023095-4dannjjm 4213 22 ( ( -LRB- cord-023095-4dannjjm 4213 23 PTH PTH NNP cord-023095-4dannjjm 4213 24 ) ) -RRB- cord-023095-4dannjjm 4213 25 and and CC cord-023095-4dannjjm 4213 26 calcitriol calcitriol NN cord-023095-4dannjjm 4213 27 in in IN cord-023095-4dannjjm 4213 28 cats cat NNS cord-023095-4dannjjm 4213 29 at at IN cord-023095-4dannjjm 4213 30 different different JJ cord-023095-4dannjjm 4213 31 stages stage NNS cord-023095-4dannjjm 4213 32 of of IN cord-023095-4dannjjm 4213 33 CKD CKD NNP cord-023095-4dannjjm 4213 34 . . . cord-023095-4dannjjm 4214 1 Progressive progressive JJ cord-023095-4dannjjm 4214 2 non non JJ cord-023095-4dannjjm 4214 3 - - JJ cord-023095-4dannjjm 4214 4 cardiogenic cardiogenic JJ cord-023095-4dannjjm 4214 5 edema edema NN cord-023095-4dannjjm 4214 6 and and CC cord-023095-4dannjjm 4214 7 lung lung NN cord-023095-4dannjjm 4214 8 dysfunction dysfunction NN cord-023095-4dannjjm 4214 9 are be VBP cord-023095-4dannjjm 4214 10 common common JJ cord-023095-4dannjjm 4214 11 complications complication NNS cord-023095-4dannjjm 4214 12 of of IN cord-023095-4dannjjm 4214 13 acute acute JJ cord-023095-4dannjjm 4214 14 kidney kidney NN cord-023095-4dannjjm 4214 15 injury injury NN cord-023095-4dannjjm 4214 16 ( ( -LRB- cord-023095-4dannjjm 4214 17 AKI AKI NNP cord-023095-4dannjjm 4214 18 ) ) -RRB- cord-023095-4dannjjm 4214 19 in in IN cord-023095-4dannjjm 4214 20 people people NNS cord-023095-4dannjjm 4214 21 . . . cord-023095-4dannjjm 4215 1 Pulmonary pulmonary JJ cord-023095-4dannjjm 4215 2 abnormalities abnormality NNS cord-023095-4dannjjm 4215 3 have have VBP cord-023095-4dannjjm 4215 4 not not RB cord-023095-4dannjjm 4215 5 been be VBN cord-023095-4dannjjm 4215 6 systematically systematically RB cord-023095-4dannjjm 4215 7 reviewed review VBN cord-023095-4dannjjm 4215 8 in in IN cord-023095-4dannjjm 4215 9 dogs dog NNS cord-023095-4dannjjm 4215 10 with with IN cord-023095-4dannjjm 4215 11 renal renal JJ cord-023095-4dannjjm 4215 12 azotemia azotemia NN cord-023095-4dannjjm 4215 13 , , , cord-023095-4dannjjm 4215 14 but but CC cord-023095-4dannjjm 4215 15 anecdotal anecdotal JJ cord-023095-4dannjjm 4215 16 reports report NNS cord-023095-4dannjjm 4215 17 of of IN cord-023095-4dannjjm 4215 18 dogs dog NNS cord-023095-4dannjjm 4215 19 with with IN cord-023095-4dannjjm 4215 20 AKI AKI NNP cord-023095-4dannjjm 4215 21 and and CC cord-023095-4dannjjm 4215 22 concurrent concurrent JJ cord-023095-4dannjjm 4215 23 non non JJ cord-023095-4dannjjm 4215 24 - - JJ cord-023095-4dannjjm 4215 25 cardiogenic cardiogenic JJ cord-023095-4dannjjm 4215 26 pulmonary pulmonary JJ cord-023095-4dannjjm 4215 27 edema edema NN cord-023095-4dannjjm 4215 28 are be VBP cord-023095-4dannjjm 4215 29 suggestive suggestive JJ cord-023095-4dannjjm 4215 30 of of IN cord-023095-4dannjjm 4215 31 uremic uremic JJ cord-023095-4dannjjm 4215 32 pneumonopathy pneumonopathy NN cord-023095-4dannjjm 4215 33 ( ( -LRB- cord-023095-4dannjjm 4215 34 UP UP NNP cord-023095-4dannjjm 4215 35 ) ) -RRB- cord-023095-4dannjjm 4215 36 , , , cord-023095-4dannjjm 4215 37 a a DT cord-023095-4dannjjm 4215 38 centrally centrally RB cord-023095-4dannjjm 4215 39 - - HYPH cord-023095-4dannjjm 4215 40 distributed distribute VBN cord-023095-4dannjjm 4215 41 pulmonary pulmonary JJ cord-023095-4dannjjm 4215 42 edema edema NN cord-023095-4dannjjm 4215 43 syndrome syndrome NN cord-023095-4dannjjm 4215 44 associated associate VBN cord-023095-4dannjjm 4215 45 with with IN cord-023095-4dannjjm 4215 46 kidney kidney NN cord-023095-4dannjjm 4215 47 disease disease NN cord-023095-4dannjjm 4215 48 in in IN cord-023095-4dannjjm 4215 49 people people NNS cord-023095-4dannjjm 4215 50 . . . cord-023095-4dannjjm 4216 1 We -PRON- PRP cord-023095-4dannjjm 4216 2 therefore therefore RB cord-023095-4dannjjm 4216 3 hypothesized hypothesize VBD cord-023095-4dannjjm 4216 4 that that IN cord-023095-4dannjjm 4216 5 pulmonary pulmonary NN cord-023095-4dannjjm 4216 6 - - HYPH cord-023095-4dannjjm 4216 7 associated associate VBN cord-023095-4dannjjm 4216 8 clinical clinical JJ cord-023095-4dannjjm 4216 9 signs sign NNS cord-023095-4dannjjm 4216 10 or or CC cord-023095-4dannjjm 4216 11 thoracic thoracic JJ cord-023095-4dannjjm 4216 12 radiograph radiograph NN cord-023095-4dannjjm 4216 13 abnormalities abnormality NNS cord-023095-4dannjjm 4216 14 are be VBP cord-023095-4dannjjm 4216 15 more more RBR cord-023095-4dannjjm 4216 16 common common JJ cord-023095-4dannjjm 4216 17 in in IN cord-023095-4dannjjm 4216 18 dogs dog NNS cord-023095-4dannjjm 4216 19 with with IN cord-023095-4dannjjm 4216 20 renal renal JJ cord-023095-4dannjjm 4216 21 azotemia azotemia NN cord-023095-4dannjjm 4216 22 than than IN cord-023095-4dannjjm 4216 23 in in IN cord-023095-4dannjjm 4216 24 non non JJ cord-023095-4dannjjm 4216 25 - - JJ cord-023095-4dannjjm 4216 26 azotemic azotemic JJ cord-023095-4dannjjm 4216 27 dogs dog NNS cord-023095-4dannjjm 4216 28 , , , cord-023095-4dannjjm 4216 29 and and CC cord-023095-4dannjjm 4216 30 that that IN cord-023095-4dannjjm 4216 31 this this DT cord-023095-4dannjjm 4216 32 association association NN cord-023095-4dannjjm 4216 33 is be VBZ cord-023095-4dannjjm 4216 34 more more RBR cord-023095-4dannjjm 4216 35 likely likely JJ cord-023095-4dannjjm 4216 36 in in IN cord-023095-4dannjjm 4216 37 dogs dog NNS cord-023095-4dannjjm 4216 38 with with IN cord-023095-4dannjjm 4216 39 AKI AKI NNP cord-023095-4dannjjm 4216 40 than than IN cord-023095-4dannjjm 4216 41 dogs dog NNS cord-023095-4dannjjm 4216 42 with with IN cord-023095-4dannjjm 4216 43 chronic chronic JJ cord-023095-4dannjjm 4216 44 renal renal JJ cord-023095-4dannjjm 4216 45 failure failure NN cord-023095-4dannjjm 4216 46 ( ( -LRB- cord-023095-4dannjjm 4216 47 CRF CRF NNP cord-023095-4dannjjm 4216 48 ) ) -RRB- cord-023095-4dannjjm 4216 49 . . . cord-023095-4dannjjm 4217 1 Our -PRON- PRP$ cord-023095-4dannjjm 4217 2 study study NN cord-023095-4dannjjm 4217 3 objectives objective NNS cord-023095-4dannjjm 4217 4 were be VBD cord-023095-4dannjjm 4217 5 1 1 CD cord-023095-4dannjjm 4217 6 ) ) -RRB- cord-023095-4dannjjm 4217 7 to to TO cord-023095-4dannjjm 4217 8 describe describe VB cord-023095-4dannjjm 4217 9 thoracic thoracic JJ cord-023095-4dannjjm 4217 10 radiograph radiograph NN cord-023095-4dannjjm 4217 11 and and CC cord-023095-4dannjjm 4217 12 lung lung NN cord-023095-4dannjjm 4217 13 histopathologic histopathologic NNP cord-023095-4dannjjm 4217 14 abnormalities abnormality NNS cord-023095-4dannjjm 4217 15 in in IN cord-023095-4dannjjm 4217 16 dogs dog NNS cord-023095-4dannjjm 4217 17 with with IN cord-023095-4dannjjm 4217 18 renal renal JJ cord-023095-4dannjjm 4217 19 azotemia azotemia NN cord-023095-4dannjjm 4217 20 , , , cord-023095-4dannjjm 4217 21 2 2 CD cord-023095-4dannjjm 4217 22 ) ) -RRB- cord-023095-4dannjjm 4217 23 to to TO cord-023095-4dannjjm 4217 24 compare compare VB cord-023095-4dannjjm 4217 25 the the DT cord-023095-4dannjjm 4217 26 occurrence occurrence NN cord-023095-4dannjjm 4217 27 of of IN cord-023095-4dannjjm 4217 28 these these DT cord-023095-4dannjjm 4217 29 findings finding NNS cord-023095-4dannjjm 4217 30 in in IN cord-023095-4dannjjm 4217 31 dogs dog NNS cord-023095-4dannjjm 4217 32 with with IN cord-023095-4dannjjm 4217 33 AKI AKI NNP cord-023095-4dannjjm 4217 34 , , , cord-023095-4dannjjm 4217 35 CRF CRF NNP cord-023095-4dannjjm 4217 36 , , , cord-023095-4dannjjm 4217 37 or or CC cord-023095-4dannjjm 4217 38 non non JJ cord-023095-4dannjjm 4217 39 - - JJ cord-023095-4dannjjm 4217 40 systemic systemic JJ cord-023095-4dannjjm 4217 41 illness illness NN cord-023095-4dannjjm 4217 42 , , , cord-023095-4dannjjm 4217 43 and and CC cord-023095-4dannjjm 4217 44 3 3 LS cord-023095-4dannjjm 4217 45 ) ) -RRB- cord-023095-4dannjjm 4217 46 to to TO cord-023095-4dannjjm 4217 47 determine determine VB cord-023095-4dannjjm 4217 48 if if IN cord-023095-4dannjjm 4217 49 these these DT cord-023095-4dannjjm 4217 50 abnormalities abnormality NNS cord-023095-4dannjjm 4217 51 are be VBP cord-023095-4dannjjm 4217 52 associated associate VBN cord-023095-4dannjjm 4217 53 with with IN cord-023095-4dannjjm 4217 54 shorter short JJR cord-023095-4dannjjm 4217 55 survival survival NN cord-023095-4dannjjm 4217 56 times time NNS cord-023095-4dannjjm 4217 57 . . . cord-023095-4dannjjm 4218 1 Records record NNS cord-023095-4dannjjm 4218 2 of of IN cord-023095-4dannjjm 4218 3 dogs dog NNS cord-023095-4dannjjm 4218 4 with with IN cord-023095-4dannjjm 4218 5 renal renal JJ cord-023095-4dannjjm 4218 6 azotemia azotemia NN cord-023095-4dannjjm 4218 7 evaluated evaluate VBN cord-023095-4dannjjm 4218 8 from from IN cord-023095-4dannjjm 4218 9 1/1/2000 1/1/2000 CD cord-023095-4dannjjm 4218 10 to to IN cord-023095-4dannjjm 4218 11 8/20/2010 8/20/2010 CD cord-023095-4dannjjm 4218 12 were be VBD cord-023095-4dannjjm 4218 13 reviewed review VBN cord-023095-4dannjjm 4218 14 ; ; : cord-023095-4dannjjm 4218 15 dogs dog NNS cord-023095-4dannjjm 4218 16 which which WDT cord-023095-4dannjjm 4218 17 could could MD cord-023095-4dannjjm 4218 18 be be VB cord-023095-4dannjjm 4218 19 classified classify VBN cord-023095-4dannjjm 4218 20 as as IN cord-023095-4dannjjm 4218 21 having have VBG cord-023095-4dannjjm 4218 22 AKI AKI NNP cord-023095-4dannjjm 4218 23 or or CC cord-023095-4dannjjm 4218 24 CRF CRF NNP cord-023095-4dannjjm 4218 25 and and CC cord-023095-4dannjjm 4218 26 which which WDT cord-023095-4dannjjm 4218 27 had have VBD cord-023095-4dannjjm 4218 28 complete complete JJ cord-023095-4dannjjm 4218 29 thoracic thoracic JJ cord-023095-4dannjjm 4218 30 radiograph radiograph NN cord-023095-4dannjjm 4218 31 studies study NNS cord-023095-4dannjjm 4218 32 available available JJ cord-023095-4dannjjm 4218 33 for for IN cord-023095-4dannjjm 4218 34 review review NN cord-023095-4dannjjm 4218 35 were be VBD cord-023095-4dannjjm 4218 36 included include VBN cord-023095-4dannjjm 4218 37 . . . cord-023095-4dannjjm 4219 1 Dogs dog NNS cord-023095-4dannjjm 4219 2 with with IN cord-023095-4dannjjm 4219 3 primary primary JJ cord-023095-4dannjjm 4219 4 intracranial intracranial JJ cord-023095-4dannjjm 4219 5 disease disease NN cord-023095-4dannjjm 4219 6 and and CC cord-023095-4dannjjm 4219 7 normal normal JJ cord-023095-4dannjjm 4219 8 serum serum NN cord-023095-4dannjjm 4219 9 creatinine creatinine NN cord-023095-4dannjjm 4219 10 and and CC cord-023095-4dannjjm 4219 11 a a DT cord-023095-4dannjjm 4219 12 complete complete JJ cord-023095-4dannjjm 4219 13 thoracic thoracic JJ cord-023095-4dannjjm 4219 14 radiograph radiograph NN cord-023095-4dannjjm 4219 15 study study NN cord-023095-4dannjjm 4219 16 were be VBD cord-023095-4dannjjm 4219 17 selected select VBN cord-023095-4dannjjm 4219 18 as as IN cord-023095-4dannjjm 4219 19 controls control NNS cord-023095-4dannjjm 4219 20 . . . cord-023095-4dannjjm 4220 1 Signalment signalment JJ cord-023095-4dannjjm 4220 2 , , , cord-023095-4dannjjm 4220 3 weight weight NN cord-023095-4dannjjm 4220 4 , , , cord-023095-4dannjjm 4220 5 presence presence NN cord-023095-4dannjjm 4220 6 of of IN cord-023095-4dannjjm 4220 7 pulmonary pulmonary NN cord-023095-4dannjjm 4220 8 - - HYPH cord-023095-4dannjjm 4220 9 related relate VBN cord-023095-4dannjjm 4220 10 clinical clinical JJ cord-023095-4dannjjm 4220 11 signs sign NNS cord-023095-4dannjjm 4220 12 , , , cord-023095-4dannjjm 4220 13 azotemia azotemia NN cord-023095-4dannjjm 4220 14 duration duration NN cord-023095-4dannjjm 4220 15 and and CC cord-023095-4dannjjm 4220 16 severity severity NN cord-023095-4dannjjm 4220 17 at at IN cord-023095-4dannjjm 4220 18 time time NN cord-023095-4dannjjm 4220 19 of of IN cord-023095-4dannjjm 4220 20 radiography radiography NN cord-023095-4dannjjm 4220 21 , , , cord-023095-4dannjjm 4220 22 and and CC cord-023095-4dannjjm 4220 23 leptospirosis leptospirosis NN cord-023095-4dannjjm 4220 24 antibody antibody NN cord-023095-4dannjjm 4220 25 titer titer NN cord-023095-4dannjjm 4220 26 were be VBD cord-023095-4dannjjm 4220 27 noted note VBN cord-023095-4dannjjm 4220 28 . . . cord-023095-4dannjjm 4221 1 Alveolar alveolar NN cord-023095-4dannjjm 4221 2 , , , cord-023095-4dannjjm 4221 3 bronchial bronchial JJ cord-023095-4dannjjm 4221 4 , , , cord-023095-4dannjjm 4221 5 interstitial interstitial JJ cord-023095-4dannjjm 4221 6 , , , cord-023095-4dannjjm 4221 7 or or CC cord-023095-4dannjjm 4221 8 nodular nodular JJ cord-023095-4dannjjm 4221 9 lesions lesion NNS cord-023095-4dannjjm 4221 10 were be VBD cord-023095-4dannjjm 4221 11 described describe VBN cord-023095-4dannjjm 4221 12 using use VBG cord-023095-4dannjjm 4221 13 a a DT cord-023095-4dannjjm 4221 14 4-point 4-point CD cord-023095-4dannjjm 4221 15 scale scale NN cord-023095-4dannjjm 4221 16 , , , cord-023095-4dannjjm 4221 17 and and CC cord-023095-4dannjjm 4221 18 lung lung NN cord-023095-4dannjjm 4221 19 tissue tissue NN cord-023095-4dannjjm 4221 20 collected collect VBN cord-023095-4dannjjm 4221 21 at at IN cord-023095-4dannjjm 4221 22 time time NN cord-023095-4dannjjm 4221 23 of of IN cord-023095-4dannjjm 4221 24 necropsy necropsy JJ cord-023095-4dannjjm 4221 25 was be VBD cord-023095-4dannjjm 4221 26 reviewed review VBN cord-023095-4dannjjm 4221 27 ; ; : cord-023095-4dannjjm 4221 28 both both CC cord-023095-4dannjjm 4221 29 the the DT cord-023095-4dannjjm 4221 30 radiologist radiologist NN cord-023095-4dannjjm 4221 31 and and CC cord-023095-4dannjjm 4221 32 pathologist pathologist NN cord-023095-4dannjjm 4221 33 were be VBD cord-023095-4dannjjm 4221 34 blinded blind VBN cord-023095-4dannjjm 4221 35 to to IN cord-023095-4dannjjm 4221 36 final final JJ cord-023095-4dannjjm 4221 37 diagnoses diagnosis NNS cord-023095-4dannjjm 4221 38 . . . cord-023095-4dannjjm 4222 1 Significance significance NN cord-023095-4dannjjm 4222 2 was be VBD cord-023095-4dannjjm 4222 3 P p NN cord-023095-4dannjjm 4222 4 o o NN cord-023095-4dannjjm 4222 5 0.05 0.05 CD cord-023095-4dannjjm 4222 6 for for IN cord-023095-4dannjjm 4222 7 all all DT cord-023095-4dannjjm 4222 8 analyses analysis NNS cord-023095-4dannjjm 4222 9 . . . cord-023095-4dannjjm 4223 1 The the DT cord-023095-4dannjjm 4223 2 final final JJ cord-023095-4dannjjm 4223 3 study study NN cord-023095-4dannjjm 4223 4 population population NN cord-023095-4dannjjm 4223 5 included include VBD cord-023095-4dannjjm 4223 6 54 54 CD cord-023095-4dannjjm 4223 7 AKI AKI NNP cord-023095-4dannjjm 4223 8 , , , cord-023095-4dannjjm 4223 9 50 50 CD cord-023095-4dannjjm 4223 10 CRF CRF NNP cord-023095-4dannjjm 4223 11 , , , cord-023095-4dannjjm 4223 12 and and CC cord-023095-4dannjjm 4223 13 63 63 CD cord-023095-4dannjjm 4223 14 control control NN cord-023095-4dannjjm 4223 15 dogs dog NNS cord-023095-4dannjjm 4223 16 . . . cord-023095-4dannjjm 4224 1 CRF CRF NNP cord-023095-4dannjjm 4224 2 dogs dog NNS cord-023095-4dannjjm 4224 3 were be VBD cord-023095-4dannjjm 4224 4 older old JJR cord-023095-4dannjjm 4224 5 ( ( -LRB- cord-023095-4dannjjm 4224 6 P p NN cord-023095-4dannjjm 4224 7 o o NN cord-023095-4dannjjm 4224 8 0.001 0.001 CD cord-023095-4dannjjm 4224 9 ) ) -RRB- cord-023095-4dannjjm 4224 10 than than IN cord-023095-4dannjjm 4224 11 AKI AKI NNP cord-023095-4dannjjm 4224 12 and and CC cord-023095-4dannjjm 4224 13 control control NN cord-023095-4dannjjm 4224 14 dogs dog NNS cord-023095-4dannjjm 4224 15 . . . cord-023095-4dannjjm 4225 1 Pulmonary pulmonary NN cord-023095-4dannjjm 4225 2 - - HYPH cord-023095-4dannjjm 4225 3 related relate VBN cord-023095-4dannjjm 4225 4 clinical clinical JJ cord-023095-4dannjjm 4225 5 signs sign NNS cord-023095-4dannjjm 4225 6 were be VBD cord-023095-4dannjjm 4225 7 more more RBR cord-023095-4dannjjm 4225 8 commonly commonly RB cord-023095-4dannjjm 4225 9 diagnosed diagnose VBN cord-023095-4dannjjm 4225 10 at at IN cord-023095-4dannjjm 4225 11 first first JJ cord-023095-4dannjjm 4225 12 evaluation evaluation NN cord-023095-4dannjjm 4225 13 in in IN cord-023095-4dannjjm 4225 14 AKI AKI NNP cord-023095-4dannjjm 4225 15 dogs dog NNS cord-023095-4dannjjm 4225 16 ( ( -LRB- cord-023095-4dannjjm 4225 17 29/53 29/53 CD cord-023095-4dannjjm 4225 18 dogs dog NNS cord-023095-4dannjjm 4225 19 , , , cord-023095-4dannjjm 4225 20 54.7 54.7 CD cord-023095-4dannjjm 4225 21 % % NN cord-023095-4dannjjm 4225 22 ) ) -RRB- cord-023095-4dannjjm 4225 23 than than IN cord-023095-4dannjjm 4225 24 in in IN cord-023095-4dannjjm 4225 25 CRF CRF NNP cord-023095-4dannjjm 4225 26 ( ( -LRB- cord-023095-4dannjjm 4225 27 13/50 13/50 CD cord-023095-4dannjjm 4225 28 , , , cord-023095-4dannjjm 4225 29 26.0 26.0 CD cord-023095-4dannjjm 4225 30 % % NN cord-023095-4dannjjm 4225 31 ; ; : cord-023095-4dannjjm 4225 32 P p NN cord-023095-4dannjjm 4225 33 5 5 CD cord-023095-4dannjjm 4225 34 0.003 0.003 CD cord-023095-4dannjjm 4225 35 ) ) -RRB- cord-023095-4dannjjm 4225 36 or or CC cord-023095-4dannjjm 4225 37 control control NN cord-023095-4dannjjm 4225 38 dogs dog NNS cord-023095-4dannjjm 4225 39 ( ( -LRB- cord-023095-4dannjjm 4225 40 9/63 9/63 CD cord-023095-4dannjjm 4225 41 , , , cord-023095-4dannjjm 4225 42 14.3 14.3 CD cord-023095-4dannjjm 4225 43 % % NN cord-023095-4dannjjm 4225 44 ; ; : cord-023095-4dannjjm 4225 45 P p NN cord-023095-4dannjjm 4225 46 o o NN cord-023095-4dannjjm 4225 47 0.001 0.001 CD cord-023095-4dannjjm 4225 48 ) ) -RRB- cord-023095-4dannjjm 4225 49 . . . cord-023095-4dannjjm 4226 1 Presence presence NN cord-023095-4dannjjm 4226 2 of of IN cord-023095-4dannjjm 4226 3 an an DT cord-023095-4dannjjm 4226 4 alveolar alveolar JJ cord-023095-4dannjjm 4226 5 pattern pattern NN cord-023095-4dannjjm 4226 6 was be VBD cord-023095-4dannjjm 4226 7 the the DT cord-023095-4dannjjm 4226 8 only only JJ cord-023095-4dannjjm 4226 9 radiographic radiographic JJ cord-023095-4dannjjm 4226 10 finding finding NN cord-023095-4dannjjm 4226 11 which which WDT cord-023095-4dannjjm 4226 12 differed differ VBD cord-023095-4dannjjm 4226 13 amongst amongst IN cord-023095-4dannjjm 4226 14 groups group NNS cord-023095-4dannjjm 4226 15 ( ( -LRB- cord-023095-4dannjjm 4226 16 more more RBR cord-023095-4dannjjm 4226 17 common common JJ cord-023095-4dannjjm 4226 18 in in IN cord-023095-4dannjjm 4226 19 AKI AKI NNP cord-023095-4dannjjm 4226 20 [ [ -LRB- cord-023095-4dannjjm 4226 21 n n NN cord-023095-4dannjjm 4226 22 5 5 CD cord-023095-4dannjjm 4226 23 8 8 CD cord-023095-4dannjjm 4226 24 , , , cord-023095-4dannjjm 4226 25 14.8 14.8 CD cord-023095-4dannjjm 4226 26 % % NN cord-023095-4dannjjm 4226 27 , , , cord-023095-4dannjjm 4226 28 P p NN cord-023095-4dannjjm 4226 29 5 5 CD cord-023095-4dannjjm 4226 30 0.047 0.047 CD cord-023095-4dannjjm 4226 31 ] ] -RRB- cord-023095-4dannjjm 4226 32 and and CC cord-023095-4dannjjm 4227 1 CRF CRF NNP cord-023095-4dannjjm 4227 2 [ [ -LRB- cord-023095-4dannjjm 4227 3 n n NN cord-023095-4dannjjm 4227 4 5 5 CD cord-023095-4dannjjm 4227 5 8 8 CD cord-023095-4dannjjm 4227 6 , , , cord-023095-4dannjjm 4227 7 16 16 CD cord-023095-4dannjjm 4227 8 % % NN cord-023095-4dannjjm 4227 9 , , , cord-023095-4dannjjm 4227 10 P p NN cord-023095-4dannjjm 4227 11 5 5 CD cord-023095-4dannjjm 4227 12 0.028 0.028 CD cord-023095-4dannjjm 4227 13 ] ] -RRB- cord-023095-4dannjjm 4227 14 dogs dog NNS cord-023095-4dannjjm 4227 15 than than IN cord-023095-4dannjjm 4227 16 in in IN cord-023095-4dannjjm 4227 17 control control NN cord-023095-4dannjjm 4227 18 dogs dog NNS cord-023095-4dannjjm 4227 19 [ [ -LRB- cord-023095-4dannjjm 4227 20 n n NN cord-023095-4dannjjm 4227 21 5 5 CD cord-023095-4dannjjm 4227 22 2 2 CD cord-023095-4dannjjm 4227 23 , , , cord-023095-4dannjjm 4227 24 3.2 3.2 CD cord-023095-4dannjjm 4227 25 % % NN cord-023095-4dannjjm 4227 26 ] ] -RRB- cord-023095-4dannjjm 4227 27 ) ) -RRB- cord-023095-4dannjjm 4227 28 . . . cord-023095-4dannjjm 4228 1 There there EX cord-023095-4dannjjm 4228 2 was be VBD cord-023095-4dannjjm 4228 3 no no DT cord-023095-4dannjjm 4228 4 association association NN cord-023095-4dannjjm 4228 5 between between IN cord-023095-4dannjjm 4228 6 presence presence NN cord-023095-4dannjjm 4228 7 of of IN cord-023095-4dannjjm 4228 8 an an DT cord-023095-4dannjjm 4228 9 alveolar alveolar JJ cord-023095-4dannjjm 4228 10 pattern pattern NN cord-023095-4dannjjm 4228 11 and and CC cord-023095-4dannjjm 4228 12 any any DT cord-023095-4dannjjm 4228 13 other other JJ cord-023095-4dannjjm 4228 14 variable variable NN cord-023095-4dannjjm 4228 15 . . . cord-023095-4dannjjm 4229 1 Alveolar alveolar NN cord-023095-4dannjjm 4229 2 mineralization mineralization NN cord-023095-4dannjjm 4229 3 was be VBD cord-023095-4dannjjm 4229 4 the the DT cord-023095-4dannjjm 4229 5 most most RBS cord-023095-4dannjjm 4229 6 common common JJ cord-023095-4dannjjm 4229 7 lesion lesion NN cord-023095-4dannjjm 4229 8 in in IN cord-023095-4dannjjm 4229 9 AKI AKI NNP cord-023095-4dannjjm 4229 10 dogs dog NNS cord-023095-4dannjjm 4229 11 ( ( -LRB- cord-023095-4dannjjm 4229 12 5/8 5/8 CD cord-023095-4dannjjm 4229 13 dogs dog NNS cord-023095-4dannjjm 4229 14 ; ; : cord-023095-4dannjjm 4229 15 62.5 62.5 CD cord-023095-4dannjjm 4229 16 % % NN cord-023095-4dannjjm 4229 17 ) ) -RRB- cord-023095-4dannjjm 4229 18 , , , cord-023095-4dannjjm 4229 19 with with IN cord-023095-4dannjjm 4229 20 concurrent concurrent JJ cord-023095-4dannjjm 4229 21 alveolar alveolar NN cord-023095-4dannjjm 4229 22 space space NN cord-023095-4dannjjm 4229 23 concretions concretion NNS cord-023095-4dannjjm 4229 24 or or CC cord-023095-4dannjjm 4229 25 mineralization mineralization NN cord-023095-4dannjjm 4229 26 of of IN cord-023095-4dannjjm 4229 27 vessels vessel NNS cord-023095-4dannjjm 4229 28 or or CC cord-023095-4dannjjm 4229 29 bronchioles bronchiole NNS cord-023095-4dannjjm 4229 30 noted note VBN cord-023095-4dannjjm 4229 31 in in IN cord-023095-4dannjjm 4229 32 1 1 CD cord-023095-4dannjjm 4229 33 dog dog NN cord-023095-4dannjjm 4229 34 each each DT cord-023095-4dannjjm 4229 35 . . . cord-023095-4dannjjm 4230 1 Necropsies Necropsies NNP cord-023095-4dannjjm 4230 2 had have VBD cord-023095-4dannjjm 4230 3 not not RB cord-023095-4dannjjm 4230 4 been be VBN cord-023095-4dannjjm 4230 5 performed perform VBN cord-023095-4dannjjm 4230 6 in in IN cord-023095-4dannjjm 4230 7 any any DT cord-023095-4dannjjm 4230 8 of of IN cord-023095-4dannjjm 4230 9 the the DT cord-023095-4dannjjm 4230 10 CRF CRF NNP cord-023095-4dannjjm 4230 11 dogs dog NNS cord-023095-4dannjjm 4230 12 , , , cord-023095-4dannjjm 4230 13 but but CC cord-023095-4dannjjm 4230 14 mineralization mineralization NN cord-023095-4dannjjm 4230 15 was be VBD cord-023095-4dannjjm 4230 16 not not RB cord-023095-4dannjjm 4230 17 seen see VBN cord-023095-4dannjjm 4230 18 in in IN cord-023095-4dannjjm 4230 19 lung lung NN cord-023095-4dannjjm 4230 20 tissues tissue NNS cord-023095-4dannjjm 4230 21 from from IN cord-023095-4dannjjm 4230 22 any any DT cord-023095-4dannjjm 4230 23 control control NN cord-023095-4dannjjm 4230 24 dogs dog NNS cord-023095-4dannjjm 4230 25 ( ( -LRB- cord-023095-4dannjjm 4230 26 n n NN cord-023095-4dannjjm 4230 27 5 5 CD cord-023095-4dannjjm 4230 28 9 9 CD cord-023095-4dannjjm 4230 29 ) ) -RRB- cord-023095-4dannjjm 4230 30 . . . cord-023095-4dannjjm 4231 1 Neither neither DT cord-023095-4dannjjm 4231 2 pulmonary pulmonary JJ cord-023095-4dannjjm 4231 3 - - HYPH cord-023095-4dannjjm 4231 4 associated associate VBN cord-023095-4dannjjm 4231 5 clinical clinical JJ cord-023095-4dannjjm 4231 6 signs sign NNS cord-023095-4dannjjm 4231 7 nor nor CC cord-023095-4dannjjm 4231 8 alveolar alveolar JJ cord-023095-4dannjjm 4231 9 pattern pattern NN cord-023095-4dannjjm 4231 10 were be VBD cord-023095-4dannjjm 4231 11 associated associate VBN cord-023095-4dannjjm 4231 12 with with IN cord-023095-4dannjjm 4231 13 median median JJ cord-023095-4dannjjm 4231 14 number number NN cord-023095-4dannjjm 4231 15 of of IN cord-023095-4dannjjm 4231 16 days day NNS cord-023095-4dannjjm 4231 17 from from IN cord-023095-4dannjjm 4231 18 discharge discharge NN cord-023095-4dannjjm 4231 19 until until IN cord-023095-4dannjjm 4231 20 death death NN cord-023095-4dannjjm 4231 21 in in IN cord-023095-4dannjjm 4231 22 dogs dog NNS cord-023095-4dannjjm 4231 23 with with IN cord-023095-4dannjjm 4231 24 AKI AKI NNP cord-023095-4dannjjm 4231 25 ( ( -LRB- cord-023095-4dannjjm 4231 26 P p NN cord-023095-4dannjjm 4231 27 5 5 CD cord-023095-4dannjjm 4231 28 0.220 0.220 CD cord-023095-4dannjjm 4231 29 and and CC cord-023095-4dannjjm 4231 30 0.468 0.468 CD cord-023095-4dannjjm 4231 31 , , , cord-023095-4dannjjm 4231 32 respectively respectively RB cord-023095-4dannjjm 4231 33 ) ) -RRB- cord-023095-4dannjjm 4231 34 or or CC cord-023095-4dannjjm 4231 35 CRF CRF NNP cord-023095-4dannjjm 4231 36 ( ( -LRB- cord-023095-4dannjjm 4231 37 P p NN cord-023095-4dannjjm 4231 38 5 5 CD cord-023095-4dannjjm 4231 39 0.280 0.280 CD cord-023095-4dannjjm 4231 40 and and CC cord-023095-4dannjjm 4231 41 0.253 0.253 CD cord-023095-4dannjjm 4231 42 , , , cord-023095-4dannjjm 4231 43 respectively respectively RB cord-023095-4dannjjm 4231 44 ) ) -RRB- cord-023095-4dannjjm 4231 45 . . . cord-023095-4dannjjm 4232 1 In in IN cord-023095-4dannjjm 4232 2 this this DT cord-023095-4dannjjm 4232 3 group group NN cord-023095-4dannjjm 4232 4 of of IN cord-023095-4dannjjm 4232 5 dogs dog NNS cord-023095-4dannjjm 4232 6 , , , cord-023095-4dannjjm 4232 7 presence presence NN cord-023095-4dannjjm 4232 8 and and CC cord-023095-4dannjjm 4232 9 type type NN cord-023095-4dannjjm 4232 10 of of IN cord-023095-4dannjjm 4232 11 radiographic radiographic JJ cord-023095-4dannjjm 4232 12 pulmonary pulmonary JJ cord-023095-4dannjjm 4232 13 abnormalities abnormality NNS cord-023095-4dannjjm 4232 14 were be VBD cord-023095-4dannjjm 4232 15 associated associate VBN cord-023095-4dannjjm 4232 16 with with IN cord-023095-4dannjjm 4232 17 renal renal JJ cord-023095-4dannjjm 4232 18 azotemia azotemia NN cord-023095-4dannjjm 4232 19 but but CC cord-023095-4dannjjm 4232 20 not not RB cord-023095-4dannjjm 4232 21 with with IN cord-023095-4dannjjm 4232 22 median median JJ cord-023095-4dannjjm 4232 23 time time NN cord-023095-4dannjjm 4232 24 until until IN cord-023095-4dannjjm 4232 25 death death NN cord-023095-4dannjjm 4232 26 . . . cord-023095-4dannjjm 4233 1 The the DT cord-023095-4dannjjm 4233 2 association association NN cord-023095-4dannjjm 4233 3 between between IN cord-023095-4dannjjm 4233 4 and and CC cord-023095-4dannjjm 4233 5 clinical clinical JJ cord-023095-4dannjjm 4233 6 relevance relevance NN cord-023095-4dannjjm 4233 7 of of IN cord-023095-4dannjjm 4233 8 alveolar alveolar JJ cord-023095-4dannjjm 4233 9 mineralization mineralization NN cord-023095-4dannjjm 4233 10 in in IN cord-023095-4dannjjm 4233 11 AKI AKI NNP cord-023095-4dannjjm 4233 12 dogs dog NNS cord-023095-4dannjjm 4233 13 were be VBD cord-023095-4dannjjm 4233 14 not not RB cord-023095-4dannjjm 4233 15 determined determine VBN cord-023095-4dannjjm 4233 16 , , , cord-023095-4dannjjm 4233 17 but but CC cord-023095-4dannjjm 4233 18 both both CC cord-023095-4dannjjm 4233 19 the the DT cord-023095-4dannjjm 4233 20 radiographic radiographic JJ cord-023095-4dannjjm 4233 21 and and CC cord-023095-4dannjjm 4233 22 histopathologic histopathologic JJ cord-023095-4dannjjm 4233 23 abnormalities abnormality NNS cord-023095-4dannjjm 4233 24 reported report VBN cord-023095-4dannjjm 4233 25 here here RB cord-023095-4dannjjm 4233 26 differ differ VBP cord-023095-4dannjjm 4233 27 from from IN cord-023095-4dannjjm 4233 28 UP up RB cord-023095-4dannjjm 4233 29 in in IN cord-023095-4dannjjm 4233 30 people people NNS cord-023095-4dannjjm 4233 31 . . . cord-023095-4dannjjm 4234 1 Chronic chronic JJ cord-023095-4dannjjm 4234 2 kidney kidney NN cord-023095-4dannjjm 4234 3 disease disease NN cord-023095-4dannjjm 4234 4 ( ( -LRB- cord-023095-4dannjjm 4234 5 CKD CKD NNP cord-023095-4dannjjm 4234 6 ) ) -RRB- cord-023095-4dannjjm 4234 7 is be VBZ cord-023095-4dannjjm 4234 8 a a DT cord-023095-4dannjjm 4234 9 common common JJ cord-023095-4dannjjm 4234 10 cause cause NN cord-023095-4dannjjm 4234 11 of of IN cord-023095-4dannjjm 4234 12 morbidity morbidity NN cord-023095-4dannjjm 4234 13 and and CC cord-023095-4dannjjm 4234 14 mortality mortality NN cord-023095-4dannjjm 4234 15 in in IN cord-023095-4dannjjm 4234 16 cats cat NNS cord-023095-4dannjjm 4234 17 . . . cord-023095-4dannjjm 4235 1 The the DT cord-023095-4dannjjm 4235 2 purpose purpose NN cord-023095-4dannjjm 4235 3 of of IN cord-023095-4dannjjm 4235 4 this this DT cord-023095-4dannjjm 4235 5 study study NN cord-023095-4dannjjm 4235 6 was be VBD cord-023095-4dannjjm 4235 7 to to TO cord-023095-4dannjjm 4235 8 investigate investigate VB cord-023095-4dannjjm 4235 9 the the DT cord-023095-4dannjjm 4235 10 effects effect NNS cord-023095-4dannjjm 4235 11 of of IN cord-023095-4dannjjm 4235 12 Chinese chinese JJ cord-023095-4dannjjm 4235 13 rhubarb rhubarb NN cord-023095-4dannjjm 4235 14 ( ( -LRB- cord-023095-4dannjjm 4235 15 Rheum Rheum NNP cord-023095-4dannjjm 4235 16 officinale officinale NN cord-023095-4dannjjm 4235 17 ) ) -RRB- cord-023095-4dannjjm 4235 18 supplementation supplementation NN cord-023095-4dannjjm 4235 19 on on IN cord-023095-4dannjjm 4235 20 the the DT cord-023095-4dannjjm 4235 21 progression progression NN cord-023095-4dannjjm 4235 22 of of IN cord-023095-4dannjjm 4235 23 feline feline JJ cord-023095-4dannjjm 4235 24 CKD CKD NNP cord-023095-4dannjjm 4235 25 . . . cord-023095-4dannjjm 4236 1 Cats cat NNS cord-023095-4dannjjm 4236 2 with with IN cord-023095-4dannjjm 4236 3 stable stable JJ cord-023095-4dannjjm 4236 4 IRIS IRIS NNP cord-023095-4dannjjm 4236 5 stage stage NN cord-023095-4dannjjm 4236 6 II II NNP cord-023095-4dannjjm 4236 7 or or CC cord-023095-4dannjjm 4236 8 III iii CD cord-023095-4dannjjm 4236 9 CKD CKD NNP cord-023095-4dannjjm 4236 10 and and CC cord-023095-4dannjjm 4236 11 without without IN cord-023095-4dannjjm 4236 12 comorbidity comorbidity NN cord-023095-4dannjjm 4236 13 were be VBD cord-023095-4dannjjm 4236 14 included include VBN cord-023095-4dannjjm 4236 15 in in IN cord-023095-4dannjjm 4236 16 the the DT cord-023095-4dannjjm 4236 17 study study NN cord-023095-4dannjjm 4236 18 . . . cord-023095-4dannjjm 4237 1 Cats cat NNS cord-023095-4dannjjm 4237 2 were be VBD cord-023095-4dannjjm 4237 3 divided divide VBN cord-023095-4dannjjm 4237 4 into into IN cord-023095-4dannjjm 4237 5 3 3 CD cord-023095-4dannjjm 4237 6 treatment treatment NN cord-023095-4dannjjm 4237 7 groups group NNS cord-023095-4dannjjm 4237 8 and and CC cord-023095-4dannjjm 4237 9 administered administer VBN cord-023095-4dannjjm 4237 10 rhubarb rhubarb NN cord-023095-4dannjjm 4237 11 extract extract NN cord-023095-4dannjjm 4237 12 ( ( -LRB- cord-023095-4dannjjm 4237 13 Group group NN cord-023095-4dannjjm 4237 14 1 1 CD cord-023095-4dannjjm 4237 15 , , , cord-023095-4dannjjm 4237 16 Rubenal Rubenal NNP cord-023095-4dannjjm 4237 17 s s NNP cord-023095-4dannjjm 4237 18 , , , cord-023095-4dannjjm 4237 19 Vetoquinol Vetoquinol NNP cord-023095-4dannjjm 4237 20 , , , cord-023095-4dannjjm 4237 21 75 75 CD cord-023095-4dannjjm 4237 22 mg mg NN cord-023095-4dannjjm 4237 23 tablet tablet NN cord-023095-4dannjjm 4237 24 PO PO NNP cord-023095-4dannjjm 4237 25 q q NNP cord-023095-4dannjjm 4237 26 12 12 CD cord-023095-4dannjjm 4237 27 h h NNP cord-023095-4dannjjm 4237 28 ) ) -RRB- cord-023095-4dannjjm 4237 29 , , , cord-023095-4dannjjm 4237 30 benazepril benazepril NNP cord-023095-4dannjjm 4237 31 as as IN cord-023095-4dannjjm 4237 32 a a DT cord-023095-4dannjjm 4237 33 positive positive JJ cord-023095-4dannjjm 4237 34 control control NN cord-023095-4dannjjm 4237 35 ( ( -LRB- cord-023095-4dannjjm 4237 36 Group Group NNP cord-023095-4dannjjm 4237 37 2 2 CD cord-023095-4dannjjm 4237 38 , , , cord-023095-4dannjjm 4237 39 0.5 0.5 CD cord-023095-4dannjjm 4237 40 mg mg NNP cord-023095-4dannjjm 4237 41 / / SYM cord-023095-4dannjjm 4237 42 kg kg NNP cord-023095-4dannjjm 4237 43 PO po NN cord-023095-4dannjjm 4237 44 q q NNP cord-023095-4dannjjm 4237 45 24 24 CD cord-023095-4dannjjm 4237 46 h h NNP cord-023095-4dannjjm 4237 47 ) ) -RRB- cord-023095-4dannjjm 4237 48 , , , cord-023095-4dannjjm 4237 49 or or CC cord-023095-4dannjjm 4237 50 both both DT cord-023095-4dannjjm 4237 51 ( ( -LRB- cord-023095-4dannjjm 4237 52 Group Group NNP cord-023095-4dannjjm 4237 53 3 3 CD cord-023095-4dannjjm 4237 54 ) ) -RRB- cord-023095-4dannjjm 4237 55 . . . cord-023095-4dannjjm 4238 1 Cats cat NNS cord-023095-4dannjjm 4238 2 were be VBD cord-023095-4dannjjm 4238 3 fed feed VBN cord-023095-4dannjjm 4238 4 a a DT cord-023095-4dannjjm 4238 5 commercial commercial JJ cord-023095-4dannjjm 4238 6 renal renal JJ cord-023095-4dannjjm 4238 7 specific specific JJ cord-023095-4dannjjm 4238 8 diet diet NN cord-023095-4dannjjm 4238 9 and and CC cord-023095-4dannjjm 4238 10 enteric enteric JJ cord-023095-4dannjjm 4238 11 phosphate phosphate NN cord-023095-4dannjjm 4238 12 binder binder NN cord-023095-4dannjjm 4238 13 as as IN cord-023095-4dannjjm 4238 14 appropriate appropriate JJ cord-023095-4dannjjm 4238 15 . . . cord-023095-4dannjjm 4239 1 Body body NN cord-023095-4dannjjm 4239 2 weight weight NN cord-023095-4dannjjm 4239 3 , , , cord-023095-4dannjjm 4239 4 laboratory laboratory NN cord-023095-4dannjjm 4239 5 data datum NNS cord-023095-4dannjjm 4239 6 , , , cord-023095-4dannjjm 4239 7 and and CC cord-023095-4dannjjm 4239 8 blood blood NN cord-023095-4dannjjm 4239 9 pressure pressure NN cord-023095-4dannjjm 4239 10 were be VBD cord-023095-4dannjjm 4239 11 recorded record VBN cord-023095-4dannjjm 4239 12 every every DT cord-023095-4dannjjm 4239 13 3 3 CD cord-023095-4dannjjm 4239 14 months month NNS cord-023095-4dannjjm 4239 15 for for IN cord-023095-4dannjjm 4239 16 up up IN cord-023095-4dannjjm 4239 17 to to TO cord-023095-4dannjjm 4239 18 34 34 CD cord-023095-4dannjjm 4239 19 months month NNS cord-023095-4dannjjm 4239 20 . . . cord-023095-4dannjjm 4240 1 Variables variable NNS cord-023095-4dannjjm 4240 2 between between IN cord-023095-4dannjjm 4240 3 groups group NNS cord-023095-4dannjjm 4240 4 at at IN cord-023095-4dannjjm 4240 5 enrollment enrollment NN cord-023095-4dannjjm 4240 6 and and CC cord-023095-4dannjjm 4240 7 within within IN cord-023095-4dannjjm 4240 8 groups group NNS cord-023095-4dannjjm 4240 9 over over IN cord-023095-4dannjjm 4240 10 visits visit NNS cord-023095-4dannjjm 4240 11 were be VBD cord-023095-4dannjjm 4240 12 compared compare VBN cord-023095-4dannjjm 4240 13 with with IN cord-023095-4dannjjm 4240 14 ANOVA ANOVA NNP cord-023095-4dannjjm 4240 15 and and CC cord-023095-4dannjjm 4240 16 repeated repeat VBN cord-023095-4dannjjm 4240 17 measures measure NNS cord-023095-4dannjjm 4240 18 ANO ANO NNP cord-023095-4dannjjm 4240 19 - - HYPH cord-023095-4dannjjm 4240 20 VA VA NNP cord-023095-4dannjjm 4240 21 , , , cord-023095-4dannjjm 4240 22 respectively respectively RB cord-023095-4dannjjm 4240 23 . . . cord-023095-4dannjjm 4241 1 A a DT cord-023095-4dannjjm 4241 2 treatment treatment NN cord-023095-4dannjjm 4241 3 by by IN cord-023095-4dannjjm 4241 4 visit visit NN cord-023095-4dannjjm 4241 5 interaction interaction NN cord-023095-4dannjjm 4241 6 term term NN cord-023095-4dannjjm 4241 7 was be VBD cord-023095-4dannjjm 4241 8 included include VBN cord-023095-4dannjjm 4241 9 in in IN cord-023095-4dannjjm 4241 10 all all DT cord-023095-4dannjjm 4241 11 repeated repeat VBN cord-023095-4dannjjm 4241 12 measures measure NNS cord-023095-4dannjjm 4241 13 models model NNS cord-023095-4dannjjm 4241 14 . . . cord-023095-4dannjjm 4242 1 Significance significance NN cord-023095-4dannjjm 4242 2 was be VBD cord-023095-4dannjjm 4242 3 set set VBN cord-023095-4dannjjm 4242 4 at at IN cord-023095-4dannjjm 4242 5 p p NN cord-023095-4dannjjm 4242 6 0.05 0.05 CD cord-023095-4dannjjm 4242 7 . . . cord-023095-4dannjjm 4243 1 Except except IN cord-023095-4dannjjm 4243 2 for for IN cord-023095-4dannjjm 4243 3 body body NN cord-023095-4dannjjm 4243 4 weight weight NN cord-023095-4dannjjm 4243 5 there there EX cord-023095-4dannjjm 4243 6 was be VBD cord-023095-4dannjjm 4243 7 no no DT cord-023095-4dannjjm 4243 8 significant significant JJ cord-023095-4dannjjm 4243 9 differences difference NNS cord-023095-4dannjjm 4243 10 between between IN cord-023095-4dannjjm 4243 11 treatment treatment NN cord-023095-4dannjjm 4243 12 groups group NNS cord-023095-4dannjjm 4243 13 at at IN cord-023095-4dannjjm 4243 14 enrollment enrollment NN cord-023095-4dannjjm 4243 15 . . . cord-023095-4dannjjm 4244 1 There there EX cord-023095-4dannjjm 4244 2 was be VBD cord-023095-4dannjjm 4244 3 no no DT cord-023095-4dannjjm 4244 4 significant significant JJ cord-023095-4dannjjm 4244 5 change change NN cord-023095-4dannjjm 4244 6 in in IN cord-023095-4dannjjm 4244 7 body body NN cord-023095-4dannjjm 4244 8 weight weight NN cord-023095-4dannjjm 4244 9 , , , cord-023095-4dannjjm 4244 10 hematocrit hematocrit NN cord-023095-4dannjjm 4244 11 ( ( -LRB- cord-023095-4dannjjm 4244 12 hct hct NNP cord-023095-4dannjjm 4244 13 ) ) -RRB- cord-023095-4dannjjm 4244 14 , , , cord-023095-4dannjjm 4244 15 UPC UPC NNP cord-023095-4dannjjm 4244 16 , , , cord-023095-4dannjjm 4244 17 or or CC cord-023095-4dannjjm 4244 18 creatinine creatinine NN cord-023095-4dannjjm 4244 19 over over IN cord-023095-4dannjjm 4244 20 time time NN cord-023095-4dannjjm 4244 21 as as IN cord-023095-4dannjjm 4244 22 compared compare VBN cord-023095-4dannjjm 4244 23 to to IN cord-023095-4dannjjm 4244 24 baseline baseline NN cord-023095-4dannjjm 4244 25 within within IN cord-023095-4dannjjm 4244 26 any any DT cord-023095-4dannjjm 4244 27 group group NN cord-023095-4dannjjm 4244 28 . . . cord-023095-4dannjjm 4245 1 There there EX cord-023095-4dannjjm 4245 2 was be VBD cord-023095-4dannjjm 4245 3 no no DT cord-023095-4dannjjm 4245 4 significant significant JJ cord-023095-4dannjjm 4245 5 difference difference NN cord-023095-4dannjjm 4245 6 between between IN cord-023095-4dannjjm 4245 7 groups group NNS cord-023095-4dannjjm 4245 8 over over IN cord-023095-4dannjjm 4245 9 time time NN cord-023095-4dannjjm 4245 10 in in IN cord-023095-4dannjjm 4245 11 regards regard NNS cord-023095-4dannjjm 4245 12 to to TO cord-023095-4dannjjm 4245 13 change change VB cord-023095-4dannjjm 4245 14 in in IN cord-023095-4dannjjm 4245 15 weight weight NN cord-023095-4dannjjm 4245 16 , , , cord-023095-4dannjjm 4245 17 hct hct NN cord-023095-4dannjjm 4245 18 , , , cord-023095-4dannjjm 4245 19 UPC UPC NNP cord-023095-4dannjjm 4245 20 , , , cord-023095-4dannjjm 4245 21 or or CC cord-023095-4dannjjm 4245 22 creatinine creatinine NN cord-023095-4dannjjm 4245 23 . . . cord-023095-4dannjjm 4246 1 The the DT cord-023095-4dannjjm 4246 2 treatment treatment NN cord-023095-4dannjjm 4246 3 by by IN cord-023095-4dannjjm 4246 4 time time NN cord-023095-4dannjjm 4246 5 interaction interaction NN cord-023095-4dannjjm 4246 6 was be VBD cord-023095-4dannjjm 4246 7 non non JJ cord-023095-4dannjjm 4246 8 - - JJ cord-023095-4dannjjm 4246 9 significant significant JJ cord-023095-4dannjjm 4246 10 in in IN cord-023095-4dannjjm 4246 11 all all DT cord-023095-4dannjjm 4246 12 models model NNS cord-023095-4dannjjm 4246 13 . . . cord-023095-4dannjjm 4247 1 Although although IN cord-023095-4dannjjm 4247 2 there there EX cord-023095-4dannjjm 4247 3 was be VBD cord-023095-4dannjjm 4247 4 no no DT cord-023095-4dannjjm 4247 5 benefit benefit NN cord-023095-4dannjjm 4247 6 associated associate VBN cord-023095-4dannjjm 4247 7 with with IN cord-023095-4dannjjm 4247 8 combination combination NN cord-023095-4dannjjm 4247 9 treatment treatment NN cord-023095-4dannjjm 4247 10 , , , cord-023095-4dannjjm 4247 11 the the DT cord-023095-4dannjjm 4247 12 results result NNS cord-023095-4dannjjm 4247 13 for for IN cord-023095-4dannjjm 4247 14 rhubarb rhubarb NN cord-023095-4dannjjm 4247 15 treatment treatment NN cord-023095-4dannjjm 4247 16 alone alone RB cord-023095-4dannjjm 4247 17 were be VBD cord-023095-4dannjjm 4247 18 not not RB cord-023095-4dannjjm 4247 19 different different JJ cord-023095-4dannjjm 4247 20 from from IN cord-023095-4dannjjm 4247 21 benazepril benazepril NNP cord-023095-4dannjjm 4247 22 treatment treatment NNP cord-023095-4dannjjm 4247 23 . . . cord-023095-4dannjjm 4248 1 Azodyl Azodyl NNP cord-023095-4dannjjm 4248 2 , , , cord-023095-4dannjjm 4248 3 an an DT cord-023095-4dannjjm 4248 4 encapsulated encapsulate VBN cord-023095-4dannjjm 4248 5 , , , cord-023095-4dannjjm 4248 6 enteric enteric JJ cord-023095-4dannjjm 4248 7 - - HYPH cord-023095-4dannjjm 4248 8 coated coat VBN cord-023095-4dannjjm 4248 9 probiotic probiotic JJ cord-023095-4dannjjm 4248 10 / / SYM cord-023095-4dannjjm 4248 11 prebiotic prebiotic JJ cord-023095-4dannjjm 4248 12 nutraceutical nutraceutical NN cord-023095-4dannjjm 4248 13 , , , cord-023095-4dannjjm 4248 14 is be VBZ cord-023095-4dannjjm 4248 15 marketed market VBN cord-023095-4dannjjm 4248 16 for for IN cord-023095-4dannjjm 4248 17 reduction reduction NN cord-023095-4dannjjm 4248 18 of of IN cord-023095-4dannjjm 4248 19 azotemia azotemia NN cord-023095-4dannjjm 4248 20 ( ( -LRB- cord-023095-4dannjjm 4248 21 BUN BUN NNP cord-023095-4dannjjm 4248 22 & & CC cord-023095-4dannjjm 4248 23 Creatinine Creatinine NNP cord-023095-4dannjjm 4248 24 ) ) -RRB- cord-023095-4dannjjm 4248 25 in in IN cord-023095-4dannjjm 4248 26 dogs dog NNS cord-023095-4dannjjm 4248 27 and and CC cord-023095-4dannjjm 4248 28 cats cat NNS cord-023095-4dannjjm 4248 29 . . . cord-023095-4dannjjm 4249 1 Cat cat NN cord-023095-4dannjjm 4249 2 owners owner NNS cord-023095-4dannjjm 4249 3 often often RB cord-023095-4dannjjm 4249 4 sprinkle sprinkle VBP cord-023095-4dannjjm 4249 5 contents content NNS cord-023095-4dannjjm 4249 6 onto onto IN cord-023095-4dannjjm 4249 7 cat cat NN cord-023095-4dannjjm 4249 8 food food NN cord-023095-4dannjjm 4249 9 to to TO cord-023095-4dannjjm 4249 10 facilitate facilitate VB cord-023095-4dannjjm 4249 11 administration administration NN cord-023095-4dannjjm 4249 12 . . . cord-023095-4dannjjm 4250 1 However however RB cord-023095-4dannjjm 4250 2 , , , cord-023095-4dannjjm 4250 3 exposure exposure NN cord-023095-4dannjjm 4250 4 to to IN cord-023095-4dannjjm 4250 5 air air NN cord-023095-4dannjjm 4250 6 and and CC cord-023095-4dannjjm 4250 7 stomach stomach NN cord-023095-4dannjjm 4250 8 acid acid NN cord-023095-4dannjjm 4250 9 are be VBP cord-023095-4dannjjm 4250 10 thought think VBN cord-023095-4dannjjm 4250 11 to to TO cord-023095-4dannjjm 4250 12 inactivate inactivate VB cord-023095-4dannjjm 4250 13 the the DT cord-023095-4dannjjm 4250 14 lyophilized lyophilize VBN cord-023095-4dannjjm 4250 15 bacteria bacteria NNS cord-023095-4dannjjm 4250 16 within within IN cord-023095-4dannjjm 4250 17 the the DT cord-023095-4dannjjm 4250 18 product product NN cord-023095-4dannjjm 4250 19 . . . cord-023095-4dannjjm 4251 1 Therefore therefore RB cord-023095-4dannjjm 4251 2 , , , cord-023095-4dannjjm 4251 3 we -PRON- PRP cord-023095-4dannjjm 4251 4 examined examine VBD cord-023095-4dannjjm 4251 5 the the DT cord-023095-4dannjjm 4251 6 ability ability NN cord-023095-4dannjjm 4251 7 of of IN cord-023095-4dannjjm 4251 8 foodsprinkled foodsprinkled NNP cord-023095-4dannjjm 4251 9 Azodyl Azodyl NNP cord-023095-4dannjjm 4251 10 to to TO cord-023095-4dannjjm 4251 11 reduce reduce VB cord-023095-4dannjjm 4251 12 azotemia azotemia NN cord-023095-4dannjjm 4251 13 in in IN cord-023095-4dannjjm 4251 14 cats cat NNS cord-023095-4dannjjm 4251 15 with with IN cord-023095-4dannjjm 4251 16 CKD CKD NNP cord-023095-4dannjjm 4251 17 . . . cord-023095-4dannjjm 4252 1 10 10 CD cord-023095-4dannjjm 4252 2 cats cat NNS cord-023095-4dannjjm 4252 3 with with IN cord-023095-4dannjjm 4252 4 CKD CKD NNP cord-023095-4dannjjm 4252 5 were be VBD cord-023095-4dannjjm 4252 6 enrolled enrol VBN cord-023095-4dannjjm 4252 7 in in IN cord-023095-4dannjjm 4252 8 the the DT cord-023095-4dannjjm 4252 9 study study NN cord-023095-4dannjjm 4252 10 and and CC cord-023095-4dannjjm 4252 11 randomized randomize VBD cord-023095-4dannjjm 4252 12 receive receive VBP cord-023095-4dannjjm 4252 13 Azodyl Azodyl NNP cord-023095-4dannjjm 4252 14 or or CC cord-023095-4dannjjm 4252 15 placebo placebo NN cord-023095-4dannjjm 4252 16 . . . cord-023095-4dannjjm 4253 1 Owners owner NNS cord-023095-4dannjjm 4253 2 were be VBD cord-023095-4dannjjm 4253 3 provided provide VBN cord-023095-4dannjjm 4253 4 with with IN cord-023095-4dannjjm 4253 5 3 3 CD cord-023095-4dannjjm 4253 6 - - SYM cord-023095-4dannjjm 4253 7 4 4 CD cord-023095-4dannjjm 4253 8 capsules capsule NNS cord-023095-4dannjjm 4253 9 of of IN cord-023095-4dannjjm 4253 10 Azodyl Azodyl NNP cord-023095-4dannjjm 4253 11 prior prior RB cord-023095-4dannjjm 4253 12 to to IN cord-023095-4dannjjm 4253 13 enrollment enrollment NN cord-023095-4dannjjm 4253 14 to to TO cord-023095-4dannjjm 4253 15 ensure ensure VB cord-023095-4dannjjm 4253 16 compliance compliance NN cord-023095-4dannjjm 4253 17 with with IN cord-023095-4dannjjm 4253 18 administration administration NN cord-023095-4dannjjm 4253 19 . . . cord-023095-4dannjjm 4254 1 2 2 LS cord-023095-4dannjjm 4254 2 baseline baseline JJ cord-023095-4dannjjm 4254 3 blood blood NN cord-023095-4dannjjm 4254 4 samples sample NNS cord-023095-4dannjjm 4254 5 were be VBD cord-023095-4dannjjm 4254 6 obtained obtain VBN cord-023095-4dannjjm 4254 7 1 1 CD cord-023095-4dannjjm 4254 8 month month NN cord-023095-4dannjjm 4254 9 apart apart RB cord-023095-4dannjjm 4254 10 , , , cord-023095-4dannjjm 4254 11 and and CC cord-023095-4dannjjm 4255 1 then then RB cord-023095-4dannjjm 4255 2 1 1 CD cord-023095-4dannjjm 4255 3 & & CC cord-023095-4dannjjm 4255 4 2 2 CD cord-023095-4dannjjm 4255 5 months month NNS cord-023095-4dannjjm 4255 6 after after IN cord-023095-4dannjjm 4255 7 beginning begin VBG cord-023095-4dannjjm 4255 8 therapy therapy NN cord-023095-4dannjjm 4255 9 . . . cord-023095-4dannjjm 4256 1 Clinicians clinician NNS cord-023095-4dannjjm 4256 2 and and CC cord-023095-4dannjjm 4256 3 owners owner NNS cord-023095-4dannjjm 4256 4 were be VBD cord-023095-4dannjjm 4256 5 masked mask VBN cord-023095-4dannjjm 4256 6 as as IN cord-023095-4dannjjm 4256 7 to to IN cord-023095-4dannjjm 4256 8 medication medication NN cord-023095-4dannjjm 4256 9 assignment assignment NN cord-023095-4dannjjm 4256 10 . . . cord-023095-4dannjjm 4257 1 We -PRON- PRP cord-023095-4dannjjm 4257 2 hypothesized hypothesize VBD cord-023095-4dannjjm 4257 3 that that IN cord-023095-4dannjjm 4257 4 a a DT cord-023095-4dannjjm 4257 5 30 30 CD cord-023095-4dannjjm 4257 6 % % NN cord-023095-4dannjjm 4257 7 decrease decrease NN cord-023095-4dannjjm 4257 8 in in IN cord-023095-4dannjjm 4257 9 BUN bun NN cord-023095-4dannjjm 4257 10 and/or and/or CC cord-023095-4dannjjm 4257 11 creat creat VB cord-023095-4dannjjm 4257 12 in in IN cord-023095-4dannjjm 4257 13 the the DT cord-023095-4dannjjm 4257 14 Azodyl Azodyl NNP cord-023095-4dannjjm 4257 15 group group NN cord-023095-4dannjjm 4257 16 would would MD cord-023095-4dannjjm 4257 17 be be VB cord-023095-4dannjjm 4257 18 significant significant JJ cord-023095-4dannjjm 4257 19 , , , cord-023095-4dannjjm 4257 20 and and CC cord-023095-4dannjjm 4257 21 set set VBD cord-023095-4dannjjm 4257 22 a a DT cord-023095-4dannjjm 4257 23 5 5 CD cord-023095-4dannjjm 4257 24 0.2 0.2 CD cord-023095-4dannjjm 4257 25 . . . cord-023095-4dannjjm 4258 1 In in IN cord-023095-4dannjjm 4258 2 order order NN cord-023095-4dannjjm 4258 3 to to TO cord-023095-4dannjjm 4258 4 maximize maximize VB cord-023095-4dannjjm 4258 5 the the DT cord-023095-4dannjjm 4258 6 probability probability NN cord-023095-4dannjjm 4258 7 of of IN cord-023095-4dannjjm 4258 8 detecting detect VBG cord-023095-4dannjjm 4258 9 a a DT cord-023095-4dannjjm 4258 10 difference difference NN cord-023095-4dannjjm 4258 11 , , , cord-023095-4dannjjm 4258 12 we -PRON- PRP cord-023095-4dannjjm 4258 13 determined determine VBD cord-023095-4dannjjm 4258 14 the the DT cord-023095-4dannjjm 4258 15 % % NN cord-023095-4dannjjm 4258 16 change change NN cord-023095-4dannjjm 4258 17 as as IN cord-023095-4dannjjm 4258 18 being be VBG cord-023095-4dannjjm 4258 19 the the DT cord-023095-4dannjjm 4258 20 difference difference NN cord-023095-4dannjjm 4258 21 between between IN cord-023095-4dannjjm 4258 22 the the DT cord-023095-4dannjjm 4258 23 maximal maximal JJ cord-023095-4dannjjm 4258 24 baseline baseline JJ cord-023095-4dannjjm 4258 25 analyte analyte NN cord-023095-4dannjjm 4258 26 concentration concentration NN cord-023095-4dannjjm 4258 27 and and CC cord-023095-4dannjjm 4258 28 minimal minimal JJ cord-023095-4dannjjm 4258 29 therapeutic therapeutic JJ cord-023095-4dannjjm 4258 30 concentration concentration NN cord-023095-4dannjjm 4258 31 . . . cord-023095-4dannjjm 4259 1 We -PRON- PRP cord-023095-4dannjjm 4259 2 compared compare VBD cord-023095-4dannjjm 4259 3 the the DT cord-023095-4dannjjm 4259 4 % % NN cord-023095-4dannjjm 4259 5 change change NN cord-023095-4dannjjm 4259 6 between between IN cord-023095-4dannjjm 4259 7 groups group NNS cord-023095-4dannjjm 4259 8 by by IN cord-023095-4dannjjm 4259 9 Mann Mann NNP cord-023095-4dannjjm 4259 10 - - HYPH cord-023095-4dannjjm 4259 11 Whitney Whitney NNP cord-023095-4dannjjm 4259 12 U U NNP cord-023095-4dannjjm 4259 13 Test Test NNP cord-023095-4dannjjm 4259 14 . . . cord-023095-4dannjjm 4260 1 BUN bun NN cord-023095-4dannjjm 4260 2 and and CC cord-023095-4dannjjm 4260 3 creatinine creatinine NN cord-023095-4dannjjm 4260 4 did do VBD cord-023095-4dannjjm 4260 5 not not RB cord-023095-4dannjjm 4260 6 differ differ VB cord-023095-4dannjjm 4260 7 between between IN cord-023095-4dannjjm 4260 8 groups group NNS cord-023095-4dannjjm 4260 9 . . . cord-023095-4dannjjm 4261 1 Based base VBN cord-023095-4dannjjm 4261 2 on on IN cord-023095-4dannjjm 4261 3 these these DT cord-023095-4dannjjm 4261 4 results result NNS cord-023095-4dannjjm 4261 5 , , , cord-023095-4dannjjm 4261 6 Azodyl Azodyl NNP cord-023095-4dannjjm 4261 7 , , , cord-023095-4dannjjm 4261 8 applied apply VBN cord-023095-4dannjjm 4261 9 by by IN cord-023095-4dannjjm 4261 10 sprinkling sprinkle VBG cord-023095-4dannjjm 4261 11 onto onto IN cord-023095-4dannjjm 4261 12 food food NN cord-023095-4dannjjm 4261 13 fails fail VBZ cord-023095-4dannjjm 4261 14 to to TO cord-023095-4dannjjm 4261 15 reduce reduce VB cord-023095-4dannjjm 4261 16 azotemia azotemia NN cord-023095-4dannjjm 4261 17 in in IN cord-023095-4dannjjm 4261 18 cats cat NNS cord-023095-4dannjjm 4261 19 with with IN cord-023095-4dannjjm 4261 20 CKD CKD NNP cord-023095-4dannjjm 4261 21 . . . cord-023095-4dannjjm 4262 1 Whether whether IN cord-023095-4dannjjm 4262 2 intact intact JJ cord-023095-4dannjjm 4262 3 capsule capsule NN cord-023095-4dannjjm 4262 4 administration administration NN cord-023095-4dannjjm 4262 5 reduces reduce VBZ cord-023095-4dannjjm 4262 6 azotemia azotemia NN cord-023095-4dannjjm 4262 7 in in IN cord-023095-4dannjjm 4262 8 cats cat NNS cord-023095-4dannjjm 4262 9 with with IN cord-023095-4dannjjm 4262 10 CKD CKD NNP cord-023095-4dannjjm 4262 11 remains remain VBZ cord-023095-4dannjjm 4262 12 unknown unknown JJ cord-023095-4dannjjm 4262 13 . . . cord-023095-4dannjjm 4263 1 Lower low JJR cord-023095-4dannjjm 4263 2 urinary urinary JJ cord-023095-4dannjjm 4263 3 tract tract NN cord-023095-4dannjjm 4263 4 disease disease NN cord-023095-4dannjjm 4263 5 ( ( -LRB- cord-023095-4dannjjm 4263 6 LUTD LUTD NNP cord-023095-4dannjjm 4263 7 ) ) -RRB- cord-023095-4dannjjm 4263 8 occurs occur VBZ cord-023095-4dannjjm 4263 9 commonly commonly RB cord-023095-4dannjjm 4263 10 in in IN cord-023095-4dannjjm 4263 11 cats cat NNS cord-023095-4dannjjm 4263 12 , , , cord-023095-4dannjjm 4263 13 and and CC cord-023095-4dannjjm 4263 14 idiopathic idiopathic JJ cord-023095-4dannjjm 4263 15 cystitis cystitis NN cord-023095-4dannjjm 4263 16 ( ( -LRB- cord-023095-4dannjjm 4263 17 FIC fic NN cord-023095-4dannjjm 4263 18 ) ) -RRB- cord-023095-4dannjjm 4263 19 and and CC cord-023095-4dannjjm 4263 20 urolithiasis urolithiasis NN cord-023095-4dannjjm 4263 21 account account VBP cord-023095-4dannjjm 4263 22 for for IN cord-023095-4dannjjm 4263 23 over over IN cord-023095-4dannjjm 4263 24 80 80 CD cord-023095-4dannjjm 4263 25 % % NN cord-023095-4dannjjm 4263 26 of of IN cord-023095-4dannjjm 4263 27 cases case NNS cord-023095-4dannjjm 4263 28 in in IN cord-023095-4dannjjm 4263 29 cats cat NNS cord-023095-4dannjjm 4263 30 less less JJR cord-023095-4dannjjm 4263 31 than than IN cord-023095-4dannjjm 4263 32 10 10 CD cord-023095-4dannjjm 4263 33 years year NNS cord-023095-4dannjjm 4263 34 of of IN cord-023095-4dannjjm 4263 35 age age NN cord-023095-4dannjjm 4263 36 . . . cord-023095-4dannjjm 4264 1 Although although IN cord-023095-4dannjjm 4264 2 several several JJ cord-023095-4dannjjm 4264 3 strategies strategy NNS cord-023095-4dannjjm 4264 4 have have VBP cord-023095-4dannjjm 4264 5 been be VBN cord-023095-4dannjjm 4264 6 recommended recommend VBN cord-023095-4dannjjm 4264 7 , , , cord-023095-4dannjjm 4264 8 a a DT cord-023095-4dannjjm 4264 9 common common JJ cord-023095-4dannjjm 4264 10 recommendation recommendation NN cord-023095-4dannjjm 4264 11 is be VBZ cord-023095-4dannjjm 4264 12 to to TO cord-023095-4dannjjm 4264 13 induce induce VB cord-023095-4dannjjm 4264 14 dilute dilute JJ cord-023095-4dannjjm 4264 15 urine urine NN cord-023095-4dannjjm 4264 16 resulting result VBG cord-023095-4dannjjm 4264 17 in in IN cord-023095-4dannjjm 4264 18 more more RBR cord-023095-4dannjjm 4264 19 frequent frequent JJ cord-023095-4dannjjm 4264 20 urination urination NN cord-023095-4dannjjm 4264 21 and and CC cord-023095-4dannjjm 4264 22 to to TO cord-023095-4dannjjm 4264 23 dilute dilute VB cord-023095-4dannjjm 4264 24 calculogenic calculogenic JJ cord-023095-4dannjjm 4264 25 constituents constituent NNS cord-023095-4dannjjm 4264 26 . . . cord-023095-4dannjjm 4265 1 In in IN cord-023095-4dannjjm 4265 2 addition addition NN cord-023095-4dannjjm 4265 3 to to IN cord-023095-4dannjjm 4265 4 conventional conventional JJ cord-023095-4dannjjm 4265 5 therapy therapy NN cord-023095-4dannjjm 4265 6 using use VBG cord-023095-4dannjjm 4265 7 modified modify VBN cord-023095-4dannjjm 4265 8 diets diet NNS cord-023095-4dannjjm 4265 9 , , , cord-023095-4dannjjm 4265 10 traditional traditional JJ cord-023095-4dannjjm 4265 11 Chinese chinese JJ cord-023095-4dannjjm 4265 12 and and CC cord-023095-4dannjjm 4265 13 Western western JJ cord-023095-4dannjjm 4265 14 herbs herb NNS cord-023095-4dannjjm 4265 15 have have VBP cord-023095-4dannjjm 4265 16 been be VBN cord-023095-4dannjjm 4265 17 recommended recommend VBN cord-023095-4dannjjm 4265 18 , , , cord-023095-4dannjjm 4265 19 although although IN cord-023095-4dannjjm 4265 20 only only RB cord-023095-4dannjjm 4265 21 one one CD cord-023095-4dannjjm 4265 22 , , , cord-023095-4dannjjm 4265 23 chorieto chorieto NN cord-023095-4dannjjm 4265 24 , , , cord-023095-4dannjjm 4265 25 has have VBZ cord-023095-4dannjjm 4265 26 published publish VBN cord-023095-4dannjjm 4265 27 data datum NNS cord-023095-4dannjjm 4265 28 . . . cord-023095-4dannjjm 4266 1 We -PRON- PRP cord-023095-4dannjjm 4266 2 evaluated evaluate VBD cord-023095-4dannjjm 4266 3 3 3 CD cord-023095-4dannjjm 4266 4 commonly commonly RB cord-023095-4dannjjm 4266 5 used use VBN cord-023095-4dannjjm 4266 6 herbal herbal JJ cord-023095-4dannjjm 4266 7 treatments treatment NNS cord-023095-4dannjjm 4266 8 recommended recommend VBN cord-023095-4dannjjm 4266 9 for for IN cord-023095-4dannjjm 4266 10 use use NN cord-023095-4dannjjm 4266 11 in in IN cord-023095-4dannjjm 4266 12 cats cat NNS cord-023095-4dannjjm 4266 13 with with IN cord-023095-4dannjjm 4266 14 LUTD LUTD NNP cord-023095-4dannjjm 4266 15 including include VBG cord-023095-4dannjjm 4266 16 ( ( -LRB- cord-023095-4dannjjm 4266 17 1 1 CD cord-023095-4dannjjm 4266 18 ) ) -RRB- cord-023095-4dannjjm 4266 19 San San NNP cord-023095-4dannjjm 4266 20 Ren Ren NNP cord-023095-4dannjjm 4266 21 Tang Tang NNP cord-023095-4dannjjm 4266 22 , , , cord-023095-4dannjjm 4266 23 ( ( -LRB- cord-023095-4dannjjm 4266 24 2 2 LS cord-023095-4dannjjm 4266 25 ) ) -RRB- cord-023095-4dannjjm 4267 1 Wei Wei NNP cord-023095-4dannjjm 4267 2 Ling Ling NNP cord-023095-4dannjjm 4267 3 Tang Tang NNP cord-023095-4dannjjm 4267 4 , , , cord-023095-4dannjjm 4267 5 and and CC cord-023095-4dannjjm 4268 1 ( ( -LRB- cord-023095-4dannjjm 4268 2 3 3 LS cord-023095-4dannjjm 4268 3 ) ) -RRB- cord-023095-4dannjjm 4268 4 Alisma Alisma NNP cord-023095-4dannjjm 4268 5 . . . cord-023095-4dannjjm 4269 1 We -PRON- PRP cord-023095-4dannjjm 4269 2 hypothesized hypothesize VBD cord-023095-4dannjjm 4269 3 that that IN cord-023095-4dannjjm 4269 4 these these DT cord-023095-4dannjjm 4269 5 3 3 CD cord-023095-4dannjjm 4269 6 Chinese chinese JJ cord-023095-4dannjjm 4269 7 herbal herbal JJ cord-023095-4dannjjm 4269 8 preparations preparation NNS cord-023095-4dannjjm 4269 9 would would MD cord-023095-4dannjjm 4269 10 induce induce VB cord-023095-4dannjjm 4269 11 increased increase VBN cord-023095-4dannjjm 4269 12 urine urine NN cord-023095-4dannjjm 4269 13 volume volume NN cord-023095-4dannjjm 4269 14 and and CC cord-023095-4dannjjm 4269 15 decreased decrease VBD cord-023095-4dannjjm 4269 16 urine urine NN cord-023095-4dannjjm 4269 17 saturation saturation NN cord-023095-4dannjjm 4269 18 for for IN cord-023095-4dannjjm 4269 19 calcium calcium NN cord-023095-4dannjjm 4269 20 oxalate oxalate NN cord-023095-4dannjjm 4269 21 and and CC cord-023095-4dannjjm 4269 22 struvite struvite NN cord-023095-4dannjjm 4269 23 . . . cord-023095-4dannjjm 4270 1 Six six CD cord-023095-4dannjjm 4270 2 healthy healthy JJ cord-023095-4dannjjm 4270 3 , , , cord-023095-4dannjjm 4270 4 spayed spayed JJ cord-023095-4dannjjm 4270 5 female female JJ cord-023095-4dannjjm 4270 6 , , , cord-023095-4dannjjm 4270 7 adult adult NN cord-023095-4dannjjm 4270 8 cats cat NNS cord-023095-4dannjjm 4270 9 were be VBD cord-023095-4dannjjm 4270 10 evaluated evaluate VBN cord-023095-4dannjjm 4270 11 in in IN cord-023095-4dannjjm 4270 12 a a DT cord-023095-4dannjjm 4270 13 placebocontrolled placebocontrolled JJ cord-023095-4dannjjm 4270 14 , , , cord-023095-4dannjjm 4270 15 randomized randomized JJ cord-023095-4dannjjm 4270 16 , , , cord-023095-4dannjjm 4270 17 cross cross JJ cord-023095-4dannjjm 4270 18 - - HYPH cord-023095-4dannjjm 4270 19 over over RP cord-023095-4dannjjm 4270 20 design design NN cord-023095-4dannjjm 4270 21 study study NN cord-023095-4dannjjm 4270 22 . . . cord-023095-4dannjjm 4271 1 Cats cat NNS cord-023095-4dannjjm 4271 2 were be VBD cord-023095-4dannjjm 4271 3 randomized randomize VBN cord-023095-4dannjjm 4271 4 to to IN cord-023095-4dannjjm 4271 5 1 1 CD cord-023095-4dannjjm 4271 6 of of IN cord-023095-4dannjjm 4271 7 4 4 CD cord-023095-4dannjjm 4271 8 treatments treatment NNS cord-023095-4dannjjm 4271 9 including include VBG cord-023095-4dannjjm 4271 10 placebo placebo NN cord-023095-4dannjjm 4271 11 ( ( -LRB- cord-023095-4dannjjm 4271 12 P p NN cord-023095-4dannjjm 4271 13 ) ) -RRB- cord-023095-4dannjjm 4271 14 , , , cord-023095-4dannjjm 4271 15 San San NNP cord-023095-4dannjjm 4271 16 Ren Ren NNP cord-023095-4dannjjm 4271 17 Tang Tang NNP cord-023095-4dannjjm 4271 18 ( ( -LRB- cord-023095-4dannjjm 4271 19 SRT SRT NNP cord-023095-4dannjjm 4271 20 ) ) -RRB- cord-023095-4dannjjm 4271 21 , , , cord-023095-4dannjjm 4271 22 Wei Wei NNP cord-023095-4dannjjm 4271 23 Ling Ling NNP cord-023095-4dannjjm 4271 24 Tang Tang NNP cord-023095-4dannjjm 4271 25 ( ( -LRB- cord-023095-4dannjjm 4271 26 WLT WLT NNP cord-023095-4dannjjm 4271 27 ) ) -RRB- cord-023095-4dannjjm 4271 28 , , , cord-023095-4dannjjm 4271 29 or or CC cord-023095-4dannjjm 4271 30 Alisma Alisma NNP cord-023095-4dannjjm 4271 31 ( ( -LRB- cord-023095-4dannjjm 4271 32 A a NN cord-023095-4dannjjm 4271 33 ) ) -RRB- cord-023095-4dannjjm 4271 34 . . . cord-023095-4dannjjm 4272 1 Treatment treatment NN cord-023095-4dannjjm 4272 2 was be VBD cord-023095-4dannjjm 4272 3 for for IN cord-023095-4dannjjm 4272 4 2 2 CD cord-023095-4dannjjm 4272 5 weeks week NNS cord-023095-4dannjjm 4272 6 each each DT cord-023095-4dannjjm 4272 7 with with IN cord-023095-4dannjjm 4272 8 a a DT cord-023095-4dannjjm 4272 9 1 1 CD cord-023095-4dannjjm 4272 10 week week NN cord-023095-4dannjjm 4272 11 washout washout NN cord-023095-4dannjjm 4272 12 period period NN cord-023095-4dannjjm 4272 13 between between IN cord-023095-4dannjjm 4272 14 treatments treatment NNS cord-023095-4dannjjm 4272 15 . . . cord-023095-4dannjjm 4273 1 At at IN cord-023095-4dannjjm 4273 2 end end NN cord-023095-4dannjjm 4273 3 of of IN cord-023095-4dannjjm 4273 4 each each DT cord-023095-4dannjjm 4273 5 treatment treatment NN cord-023095-4dannjjm 4273 6 period period NN cord-023095-4dannjjm 4273 7 , , , cord-023095-4dannjjm 4273 8 a a DT cord-023095-4dannjjm 4273 9 24-hour 24-hour JJ cord-023095-4dannjjm 4273 10 urine urine NN cord-023095-4dannjjm 4273 11 sample sample NN cord-023095-4dannjjm 4273 12 was be VBD cord-023095-4dannjjm 4273 13 collected collect VBN cord-023095-4dannjjm 4273 14 using use VBG cord-023095-4dannjjm 4273 15 modified modify VBN cord-023095-4dannjjm 4273 16 litter litter NN cord-023095-4dannjjm 4273 17 boxes box NNS cord-023095-4dannjjm 4273 18 . . . cord-023095-4dannjjm 4274 1 Urine urine NN cord-023095-4dannjjm 4274 2 volume volume NN cord-023095-4dannjjm 4274 3 and and CC cord-023095-4dannjjm 4274 4 biochemistries biochemistry NNS cord-023095-4dannjjm 4274 5 were be VBD cord-023095-4dannjjm 4274 6 measured measure VBN cord-023095-4dannjjm 4274 7 , , , cord-023095-4dannjjm 4274 8 and and CC cord-023095-4dannjjm 4274 9 urine urine NN cord-023095-4dannjjm 4274 10 saturation saturation NN cord-023095-4dannjjm 4274 11 for for IN cord-023095-4dannjjm 4274 12 struvite struvite NN cord-023095-4dannjjm 4274 13 and and CC cord-023095-4dannjjm 4274 14 calcium calcium NN cord-023095-4dannjjm 4274 15 oxalate oxalate NN cord-023095-4dannjjm 4274 16 was be VBD cord-023095-4dannjjm 4274 17 estimated estimate VBN cord-023095-4dannjjm 4274 18 using use VBG cord-023095-4dannjjm 4274 19 EQUIL EQUIL NNP cord-023095-4dannjjm 4274 20 1.5b 1.5b CD cord-023095-4dannjjm 4274 21 . . . cord-023095-4dannjjm 4275 1 Analysis analysis NN cord-023095-4dannjjm 4275 2 of of IN cord-023095-4dannjjm 4275 3 Variance Variance NNP cord-023095-4dannjjm 4275 4 ( ( -LRB- cord-023095-4dannjjm 4275 5 ANOVA ANOVA NNP cord-023095-4dannjjm 4275 6 ) ) -RRB- cord-023095-4dannjjm 4275 7 was be VBD cord-023095-4dannjjm 4275 8 used use VBN cord-023095-4dannjjm 4275 9 to to TO cord-023095-4dannjjm 4275 10 analyze analyze VB cord-023095-4dannjjm 4275 11 data datum NNS cord-023095-4dannjjm 4275 12 statistically statistically RB cord-023095-4dannjjm 4275 13 if if IN cord-023095-4dannjjm 4275 14 distributed distribute VBN cord-023095-4dannjjm 4275 15 normally normally RB cord-023095-4dannjjm 4275 16 and and CC cord-023095-4dannjjm 4275 17 Kruskal Kruskal NNP cord-023095-4dannjjm 4275 18 - - HYPH cord-023095-4dannjjm 4275 19 Wallis Wallis NNP cord-023095-4dannjjm 4275 20 was be VBD cord-023095-4dannjjm 4275 21 used use VBN cord-023095-4dannjjm 4275 22 to to TO cord-023095-4dannjjm 4275 23 analyze analyze VB cord-023095-4dannjjm 4275 24 data datum NNS cord-023095-4dannjjm 4275 25 statistically statistically RB cord-023095-4dannjjm 4275 26 if if IN cord-023095-4dannjjm 4275 27 data datum NNS cord-023095-4dannjjm 4275 28 were be VBD cord-023095-4dannjjm 4275 29 not not RB cord-023095-4dannjjm 4275 30 distributed distribute VBN cord-023095-4dannjjm 4275 31 normally normally RB cord-023095-4dannjjm 4275 32 . . . cord-023095-4dannjjm 4276 1 A a DT cord-023095-4dannjjm 4276 2 p p NN cord-023095-4dannjjm 4276 3 o o NN cord-023095-4dannjjm 4276 4 0.05 0.05 CD cord-023095-4dannjjm 4276 5 was be VBD cord-023095-4dannjjm 4276 6 considered consider VBN cord-023095-4dannjjm 4276 7 significant significant JJ cord-023095-4dannjjm 4276 8 . . . cord-023095-4dannjjm 4277 1 Body body NN cord-023095-4dannjjm 4277 2 weights weight NNS cord-023095-4dannjjm 4277 3 were be VBD cord-023095-4dannjjm 4277 4 not not RB cord-023095-4dannjjm 4277 5 different different JJ cord-023095-4dannjjm 4277 6 between between IN cord-023095-4dannjjm 4277 7 treatments treatment NNS cord-023095-4dannjjm 4277 8 . . . cord-023095-4dannjjm 4278 1 No no DT cord-023095-4dannjjm 4278 2 differences difference NNS cord-023095-4dannjjm 4278 3 were be VBD cord-023095-4dannjjm 4278 4 found find VBN cord-023095-4dannjjm 4278 5 in in IN cord-023095-4dannjjm 4278 6 24-hour 24-hour JJ cord-023095-4dannjjm 4278 7 urinary urinary JJ cord-023095-4dannjjm 4278 8 analyte analyte NN cord-023095-4dannjjm 4278 9 excretions excretion NNS cord-023095-4dannjjm 4278 10 , , , cord-023095-4dannjjm 4278 11 24-hour 24-hour JJ cord-023095-4dannjjm 4278 12 urine urine NN cord-023095-4dannjjm 4278 13 volume volume NN cord-023095-4dannjjm 4278 14 , , , cord-023095-4dannjjm 4278 15 urine urine NN cord-023095-4dannjjm 4278 16 pH ph NN cord-023095-4dannjjm 4278 17 , , , cord-023095-4dannjjm 4278 18 or or CC cord-023095-4dannjjm 4278 19 24-hour 24-hour JJ cord-023095-4dannjjm 4278 20 urinary urinary JJ cord-023095-4dannjjm 4278 21 saturation saturation NN cord-023095-4dannjjm 4278 22 for for IN cord-023095-4dannjjm 4278 23 calcium calcium NN cord-023095-4dannjjm 4278 24 oxalate oxalate NN cord-023095-4dannjjm 4278 25 or or CC cord-023095-4dannjjm 4278 26 struvite struvite NN cord-023095-4dannjjm 4278 27 between between IN cord-023095-4dannjjm 4278 28 treatments treatment NNS cord-023095-4dannjjm 4278 29 ( ( -LRB- cord-023095-4dannjjm 4278 30 Table table NN cord-023095-4dannjjm 4278 31 ) ) -RRB- cord-023095-4dannjjm 4278 32 . . . cord-023095-4dannjjm 4279 1 Urolithiasis Urolithiasis NNP cord-023095-4dannjjm 4279 2 is be VBZ cord-023095-4dannjjm 4279 3 a a DT cord-023095-4dannjjm 4279 4 multifactorial multifactorial JJ cord-023095-4dannjjm 4279 5 disease disease NN cord-023095-4dannjjm 4279 6 , , , cord-023095-4dannjjm 4279 7 frequent frequent JJ cord-023095-4dannjjm 4279 8 and and CC cord-023095-4dannjjm 4279 9 recurrent recurrent JJ cord-023095-4dannjjm 4279 10 in in IN cord-023095-4dannjjm 4279 11 dogs dog NNS cord-023095-4dannjjm 4279 12 in in IN cord-023095-4dannjjm 4279 13 the the DT cord-023095-4dannjjm 4279 14 worldwide worldwide NN cord-023095-4dannjjm 4279 15 , , , cord-023095-4dannjjm 4279 16 in in IN cord-023095-4dannjjm 4279 17 which which WDT cord-023095-4dannjjm 4279 18 breed breed NN cord-023095-4dannjjm 4279 19 , , , cord-023095-4dannjjm 4279 20 sex sex NN cord-023095-4dannjjm 4279 21 , , , cord-023095-4dannjjm 4279 22 age age NN cord-023095-4dannjjm 4279 23 , , , cord-023095-4dannjjm 4279 24 diet diet NN cord-023095-4dannjjm 4279 25 , , , cord-023095-4dannjjm 4279 26 some some DT cord-023095-4dannjjm 4279 27 anatomical anatomical JJ cord-023095-4dannjjm 4279 28 abnormalities abnormality NNS cord-023095-4dannjjm 4279 29 , , , cord-023095-4dannjjm 4279 30 urinary urinary JJ cord-023095-4dannjjm 4279 31 tract tract NN cord-023095-4dannjjm 4279 32 infection infection NN cord-023095-4dannjjm 4279 33 , , , cord-023095-4dannjjm 4279 34 urine urine NN cord-023095-4dannjjm 4279 35 pH ph NN cord-023095-4dannjjm 4279 36 and and CC cord-023095-4dannjjm 4279 37 some some DT cord-023095-4dannjjm 4279 38 geographical geographical JJ cord-023095-4dannjjm 4279 39 and and CC cord-023095-4dannjjm 4279 40 hereditary hereditary JJ cord-023095-4dannjjm 4279 41 features feature NNS cord-023095-4dannjjm 4279 42 in in IN cord-023095-4dannjjm 4279 43 the the DT cord-023095-4dannjjm 4279 44 populations population NNS cord-023095-4dannjjm 4279 45 studied study VBN cord-023095-4dannjjm 4279 46 have have VBP cord-023095-4dannjjm 4279 47 been be VBN cord-023095-4dannjjm 4279 48 implicated implicate VBN cord-023095-4dannjjm 4279 49 as as IN cord-023095-4dannjjm 4279 50 risk risk NN cord-023095-4dannjjm 4279 51 factors factor NNS cord-023095-4dannjjm 4279 52 . . . cord-023095-4dannjjm 4280 1 The the DT cord-023095-4dannjjm 4280 2 effective effective JJ cord-023095-4dannjjm 4280 3 long long JJ cord-023095-4dannjjm 4280 4 - - HYPH cord-023095-4dannjjm 4280 5 term term NN cord-023095-4dannjjm 4280 6 management management NN cord-023095-4dannjjm 4280 7 of of IN cord-023095-4dannjjm 4280 8 urolithiasis urolithiasis NN cord-023095-4dannjjm 4280 9 depends depend VBZ cord-023095-4dannjjm 4280 10 on on IN cord-023095-4dannjjm 4280 11 identification identification NN cord-023095-4dannjjm 4280 12 and and CC cord-023095-4dannjjm 4280 13 control control NN cord-023095-4dannjjm 4280 14 of of IN cord-023095-4dannjjm 4280 15 the the DT cord-023095-4dannjjm 4280 16 pathophysiological pathophysiological JJ cord-023095-4dannjjm 4280 17 mechanisms mechanism NNS cord-023095-4dannjjm 4280 18 involved involve VBN cord-023095-4dannjjm 4280 19 , , , cord-023095-4dannjjm 4280 20 which which WDT cord-023095-4dannjjm 4280 21 , , , cord-023095-4dannjjm 4280 22 in in IN cord-023095-4dannjjm 4280 23 turn turn NN cord-023095-4dannjjm 4280 24 , , , cord-023095-4dannjjm 4280 25 depend depend VB cord-023095-4dannjjm 4280 26 on on IN cord-023095-4dannjjm 4280 27 accurate accurate JJ cord-023095-4dannjjm 4280 28 knowledge knowledge NN cord-023095-4dannjjm 4280 29 of of IN cord-023095-4dannjjm 4280 30 the the DT cord-023095-4dannjjm 4280 31 mineral mineral NN cord-023095-4dannjjm 4280 32 composition composition NN cord-023095-4dannjjm 4280 33 of of IN cord-023095-4dannjjm 4280 34 the the DT cord-023095-4dannjjm 4280 35 uroliths urolith NNS cord-023095-4dannjjm 4280 36 . . . cord-023095-4dannjjm 4281 1 The the DT cord-023095-4dannjjm 4281 2 aim aim NN cord-023095-4dannjjm 4281 3 of of IN cord-023095-4dannjjm 4281 4 this this DT cord-023095-4dannjjm 4281 5 study study NN cord-023095-4dannjjm 4281 6 was be VBD cord-023095-4dannjjm 4281 7 to to TO cord-023095-4dannjjm 4281 8 determine determine VB cord-023095-4dannjjm 4281 9 for for IN cord-023095-4dannjjm 4281 10 first first JJ cord-023095-4dannjjm 4281 11 occasion occasion NN cord-023095-4dannjjm 4281 12 the the DT cord-023095-4dannjjm 4281 13 main main JJ cord-023095-4dannjjm 4281 14 epidemiological epidemiological JJ cord-023095-4dannjjm 4281 15 data datum NNS cord-023095-4dannjjm 4281 16 of of IN cord-023095-4dannjjm 4281 17 canine canine JJ cord-023095-4dannjjm 4281 18 urolithiasis urolithiasis NN cord-023095-4dannjjm 4281 19 in in IN cord-023095-4dannjjm 4281 20 Mexico Mexico NNP cord-023095-4dannjjm 4281 21 . . . cord-023095-4dannjjm 4282 1 This this DT cord-023095-4dannjjm 4282 2 study study NN cord-023095-4dannjjm 4282 3 was be VBD cord-023095-4dannjjm 4282 4 developed develop VBN cord-023095-4dannjjm 4282 5 with with IN cord-023095-4dannjjm 4282 6 491 491 CD cord-023095-4dannjjm 4282 7 dogs dog NNS cord-023095-4dannjjm 4282 8 with with IN cord-023095-4dannjjm 4282 9 urolithiasis urolithiasis NN cord-023095-4dannjjm 4282 10 from from IN cord-023095-4dannjjm 4282 11 25 25 CD cord-023095-4dannjjm 4282 12 of of IN cord-023095-4dannjjm 4282 13 the the DT cord-023095-4dannjjm 4282 14 33 33 CD cord-023095-4dannjjm 4282 15 states state NNS cord-023095-4dannjjm 4282 16 of of IN cord-023095-4dannjjm 4282 17 the the DT cord-023095-4dannjjm 4282 18 country country NN cord-023095-4dannjjm 4282 19 . . . cord-023095-4dannjjm 4283 1 Chemical chemical JJ cord-023095-4dannjjm 4283 2 composition composition NN cord-023095-4dannjjm 4283 3 of of IN cord-023095-4dannjjm 4283 4 the the DT cord-023095-4dannjjm 4283 5 uroliths urolith NNS cord-023095-4dannjjm 4283 6 was be VBD cord-023095-4dannjjm 4283 7 determined determine VBN cord-023095-4dannjjm 4283 8 by by IN cord-023095-4dannjjm 4283 9 stereoscopic stereoscopic JJ cord-023095-4dannjjm 4283 10 microscopy microscopy NNS cord-023095-4dannjjm 4283 11 , , , cord-023095-4dannjjm 4283 12 infrared infrared JJ cord-023095-4dannjjm 4283 13 spectroscopy spectroscopy NN cord-023095-4dannjjm 4283 14 , , , cord-023095-4dannjjm 4283 15 scanning scanning NN cord-023095-4dannjjm 4283 16 electron electron NN cord-023095-4dannjjm 4283 17 microscopy microscopy NN cord-023095-4dannjjm 4283 18 and and CC cord-023095-4dannjjm 4283 19 X x NN cord-023095-4dannjjm 4283 20 - - NN cord-023095-4dannjjm 4283 21 ray ray NN cord-023095-4dannjjm 4283 22 microanalysis microanalysis NN cord-023095-4dannjjm 4283 23 . . . cord-023095-4dannjjm 4284 1 Urolithiasis urolithiasis NN cord-023095-4dannjjm 4284 2 affected affect VBD cord-023095-4dannjjm 4284 3 nearly nearly RB cord-023095-4dannjjm 4284 4 the the DT cord-023095-4dannjjm 4284 5 same same JJ cord-023095-4dannjjm 4284 6 number number NN cord-023095-4dannjjm 4284 7 of of IN cord-023095-4dannjjm 4284 8 males male NNS cord-023095-4dannjjm 4284 9 and and CC cord-023095-4dannjjm 4284 10 females female NNS cord-023095-4dannjjm 4284 11 ; ; : cord-023095-4dannjjm 4284 12 with with IN cord-023095-4dannjjm 4284 13 ages age NNS cord-023095-4dannjjm 4284 14 ranging range VBG cord-023095-4dannjjm 4284 15 from from IN cord-023095-4dannjjm 4284 16 two two CD cord-023095-4dannjjm 4284 17 months month NNS cord-023095-4dannjjm 4284 18 to to IN cord-023095-4dannjjm 4284 19 15 15 CD cord-023095-4dannjjm 4284 20 years year NNS cord-023095-4dannjjm 4284 21 with with IN cord-023095-4dannjjm 4284 22 a a DT cord-023095-4dannjjm 4284 23 median median JJ cord-023095-4dannjjm 4284 24 age age NN cord-023095-4dannjjm 4284 25 of of IN cord-023095-4dannjjm 4284 26 5 5 CD cord-023095-4dannjjm 4284 27 years year NNS cord-023095-4dannjjm 4284 28 . . . cord-023095-4dannjjm 4285 1 Adult adult NN cord-023095-4dannjjm 4285 2 animals animal NNS cord-023095-4dannjjm 4285 3 were be VBD cord-023095-4dannjjm 4285 4 the the DT cord-023095-4dannjjm 4285 5 most most RBS cord-023095-4dannjjm 4285 6 affected affected JJ cord-023095-4dannjjm 4285 7 . . . cord-023095-4dannjjm 4286 1 Breeds breed NNS cord-023095-4dannjjm 4286 2 more more RBR cord-023095-4dannjjm 4286 3 affected affected JJ cord-023095-4dannjjm 4286 4 were be VBD cord-023095-4dannjjm 4286 5 Schnauzer Schnauzer NNP cord-023095-4dannjjm 4286 6 miniature miniature NN cord-023095-4dannjjm 4286 7 , , , cord-023095-4dannjjm 4286 8 Poodle Poodle NNP cord-023095-4dannjjm 4286 9 , , , cord-023095-4dannjjm 4286 10 Dalmatian Dalmatian NNP cord-023095-4dannjjm 4286 11 , , , cord-023095-4dannjjm 4286 12 Yorkshire Yorkshire NNP cord-023095-4dannjjm 4286 13 terrier terrier NN cord-023095-4dannjjm 4286 14 , , , cord-023095-4dannjjm 4286 15 Scottish scottish JJ cord-023095-4dannjjm 4286 16 terrier terrier NN cord-023095-4dannjjm 4286 17 , , , cord-023095-4dannjjm 4286 18 Chihuahua Chihuahua NNP cord-023095-4dannjjm 4286 19 and and CC cord-023095-4dannjjm 4286 20 Bichon Bichon NNP cord-023095-4dannjjm 4286 21 frisee frisee NNP cord-023095-4dannjjm 4286 22 ´ ´ CD cord-023095-4dannjjm 4286 23 . . . cord-023095-4dannjjm 4287 1 Uroliths Uroliths NNP cord-023095-4dannjjm 4287 2 were be VBD cord-023095-4dannjjm 4287 3 found find VBN cord-023095-4dannjjm 4287 4 in in IN cord-023095-4dannjjm 4287 5 the the DT cord-023095-4dannjjm 4287 6 lower low JJR cord-023095-4dannjjm 4287 7 urinary urinary JJ cord-023095-4dannjjm 4287 8 tract tract NN cord-023095-4dannjjm 4287 9 in in IN cord-023095-4dannjjm 4287 10 97.74 97.74 CD cord-023095-4dannjjm 4287 11 % % NN cord-023095-4dannjjm 4287 12 of of IN cord-023095-4dannjjm 4287 13 the the DT cord-023095-4dannjjm 4287 14 cases case NNS cord-023095-4dannjjm 4287 15 . . . cord-023095-4dannjjm 4288 1 Mineral mineral NN cord-023095-4dannjjm 4288 2 composition composition NN cord-023095-4dannjjm 4288 3 of of IN cord-023095-4dannjjm 4288 4 the the DT cord-023095-4dannjjm 4288 5 uroliths urolith NNS cord-023095-4dannjjm 4288 6 was be VBD cord-023095-4dannjjm 4288 7 : : : cord-023095-4dannjjm 4288 8 Struvite Struvite NNP cord-023095-4dannjjm 4288 9 49.69 49.69 CD cord-023095-4dannjjm 4288 10 % % NN cord-023095-4dannjjm 4288 11 , , , cord-023095-4dannjjm 4288 12 followed follow VBN cord-023095-4dannjjm 4288 13 by by IN cord-023095-4dannjjm 4288 14 calcium calcium NN cord-023095-4dannjjm 4288 15 oxalate oxalate NN cord-023095-4dannjjm 4288 16 25.46 25.46 CD cord-023095-4dannjjm 4288 17 % % NN cord-023095-4dannjjm 4288 18 , , , cord-023095-4dannjjm 4288 19 purines purine NNS cord-023095-4dannjjm 4288 20 7.13 7.13 CD cord-023095-4dannjjm 4288 21 % % NN cord-023095-4dannjjm 4288 22 , , , cord-023095-4dannjjm 4288 23 silicate silicate NN cord-023095-4dannjjm 4288 24 6.72 6.72 CD cord-023095-4dannjjm 4288 25 % % NN cord-023095-4dannjjm 4288 26 , , , cord-023095-4dannjjm 4288 27 others other NNS cord-023095-4dannjjm 4288 28 0.20 0.20 CD cord-023095-4dannjjm 4288 29 % % NN cord-023095-4dannjjm 4288 30 , , , cord-023095-4dannjjm 4288 31 mixed mixed JJ cord-023095-4dannjjm 4288 32 8.15 8.15 CD cord-023095-4dannjjm 4288 33 % % NN cord-023095-4dannjjm 4288 34 and and CC cord-023095-4dannjjm 4288 35 compound compound NN cord-023095-4dannjjm 4288 36 uroliths uroliths JJ cord-023095-4dannjjm 4288 37 2.44 2.44 CD cord-023095-4dannjjm 4288 38 % % NN cord-023095-4dannjjm 4288 39 . . . cord-023095-4dannjjm 4289 1 Struvite Struvite NNP cord-023095-4dannjjm 4289 2 uroliths uroliths NN cord-023095-4dannjjm 4289 3 affected affect VBD cord-023095-4dannjjm 4289 4 females female NNS cord-023095-4dannjjm 4289 5 in in IN cord-023095-4dannjjm 4289 6 most most JJS cord-023095-4dannjjm 4289 7 cases case NNS cord-023095-4dannjjm 4289 8 , , , cord-023095-4dannjjm 4289 9 whereas whereas IN cord-023095-4dannjjm 4289 10 calcium calcium NN cord-023095-4dannjjm 4289 11 oxalate oxalate NN cord-023095-4dannjjm 4289 12 , , , cord-023095-4dannjjm 4289 13 purines purine NNS cord-023095-4dannjjm 4289 14 and and CC cord-023095-4dannjjm 4289 15 silicate silicate NN cord-023095-4dannjjm 4289 16 uroliths urolith NNS cord-023095-4dannjjm 4289 17 , , , cord-023095-4dannjjm 4289 18 were be VBD cord-023095-4dannjjm 4289 19 mainly mainly RB cord-023095-4dannjjm 4289 20 observed observe VBN cord-023095-4dannjjm 4289 21 in in IN cord-023095-4dannjjm 4289 22 males male NNS cord-023095-4dannjjm 4289 23 . . . cord-023095-4dannjjm 4290 1 Our -PRON- PRP$ cord-023095-4dannjjm 4290 2 results result NNS cord-023095-4dannjjm 4290 3 are be VBP cord-023095-4dannjjm 4290 4 similar similar JJ cord-023095-4dannjjm 4290 5 to to IN cord-023095-4dannjjm 4290 6 studies study NNS cord-023095-4dannjjm 4290 7 developed develop VBN cord-023095-4dannjjm 4290 8 in in IN cord-023095-4dannjjm 4290 9 other other JJ cord-023095-4dannjjm 4290 10 countries country NNS cord-023095-4dannjjm 4290 11 and and CC cord-023095-4dannjjm 4290 12 continents continent NNS cord-023095-4dannjjm 4290 13 , , , cord-023095-4dannjjm 4290 14 though though IN cord-023095-4dannjjm 4290 15 we -PRON- PRP cord-023095-4dannjjm 4290 16 found find VBD cord-023095-4dannjjm 4290 17 a a DT cord-023095-4dannjjm 4290 18 higher high JJR cord-023095-4dannjjm 4290 19 frequency frequency NN cord-023095-4dannjjm 4290 20 of of IN cord-023095-4dannjjm 4290 21 uroliths uroliths JJ cord-023095-4dannjjm 4290 22 containing contain VBG cord-023095-4dannjjm 4290 23 silicate silicate NN cord-023095-4dannjjm 4290 24 , , , cord-023095-4dannjjm 4290 25 either either CC cord-023095-4dannjjm 4290 26 pure pure JJ cord-023095-4dannjjm 4290 27 , , , cord-023095-4dannjjm 4290 28 mixed mixed JJ cord-023095-4dannjjm 4290 29 or or CC cord-023095-4dannjjm 4290 30 compounds compound NNS cord-023095-4dannjjm 4290 31 uroliths uroliths JJ cord-023095-4dannjjm 4290 32 ( ( -LRB- cord-023095-4dannjjm 4290 33 10.79 10.79 CD cord-023095-4dannjjm 4290 34 % % NN cord-023095-4dannjjm 4290 35 ) ) -RRB- cord-023095-4dannjjm 4290 36 ; ; : cord-023095-4dannjjm 4290 37 in in IN cord-023095-4dannjjm 4290 38 Mexico Mexico NNP cord-023095-4dannjjm 4290 39 City City NNP cord-023095-4dannjjm 4290 40 the the DT cord-023095-4dannjjm 4290 41 frequency frequency NN cord-023095-4dannjjm 4290 42 reached reach VBD cord-023095-4dannjjm 4290 43 15 15 CD cord-023095-4dannjjm 4290 44 % % NN cord-023095-4dannjjm 4290 45 . . . cord-023095-4dannjjm 4291 1 This this DT cord-023095-4dannjjm 4291 2 high high JJ cord-023095-4dannjjm 4291 3 frequency frequency NN cord-023095-4dannjjm 4291 4 may may MD cord-023095-4dannjjm 4291 5 be be VB cord-023095-4dannjjm 4291 6 due due JJ cord-023095-4dannjjm 4291 7 to to IN cord-023095-4dannjjm 4291 8 high high JJ cord-023095-4dannjjm 4291 9 consumption consumption NN cord-023095-4dannjjm 4291 10 of of IN cord-023095-4dannjjm 4291 11 silicate silicate NN cord-023095-4dannjjm 4291 12 in in IN cord-023095-4dannjjm 4291 13 home home NN cord-023095-4dannjjm 4291 14 - - HYPH cord-023095-4dannjjm 4291 15 made make VBN cord-023095-4dannjjm 4291 16 food food NN cord-023095-4dannjjm 4291 17 or or CC cord-023095-4dannjjm 4291 18 in in IN cord-023095-4dannjjm 4291 19 the the DT cord-023095-4dannjjm 4291 20 groundwater groundwater NN cord-023095-4dannjjm 4291 21 derived derive VBN cord-023095-4dannjjm 4291 22 from from IN cord-023095-4dannjjm 4291 23 aquifers aquifer NNS cord-023095-4dannjjm 4291 24 . . . cord-023095-4dannjjm 4292 1 Acknowledgments acknowledgment NNS cord-023095-4dannjjm 4292 2 : : : cord-023095-4dannjjm 4292 3 This this DT cord-023095-4dannjjm 4292 4 work work NN cord-023095-4dannjjm 4292 5 has have VBZ cord-023095-4dannjjm 4292 6 been be VBN cord-023095-4dannjjm 4292 7 partially partially RB cord-023095-4dannjjm 4292 8 supported support VBN cord-023095-4dannjjm 4292 9 by by IN cord-023095-4dannjjm 4292 10 a a DT cord-023095-4dannjjm 4292 11 project project NN cord-023095-4dannjjm 4292 12 of of IN cord-023095-4dannjjm 4292 13 Waltham Waltham NNP cord-023095-4dannjjm 4292 14 Foundation Foundation NNP cord-023095-4dannjjm 4292 15 in in IN cord-023095-4dannjjm 4292 16 Mexico Mexico NNP cord-023095-4dannjjm 4292 17 and and CC cord-023095-4dannjjm 4292 18 the the DT cord-023095-4dannjjm 4292 19 Consejo Consejo NNP cord-023095-4dannjjm 4292 20 Nacional Nacional NNP cord-023095-4dannjjm 4292 21 de de NNP cord-023095-4dannjjm 4292 22 Ciencia Ciencia NNP cord-023095-4dannjjm 4292 23 y y NNP cord-023095-4dannjjm 4292 24 Tecnologı´a Tecnologı´a NNP cord-023095-4dannjjm 4292 25 ( ( -LRB- cord-023095-4dannjjm 4292 26 CONACyT CONACyT NNP cord-023095-4dannjjm 4292 27 ) ) -RRB- cord-023095-4dannjjm 4292 28 of of IN cord-023095-4dannjjm 4292 29 Mexico Mexico NNP cord-023095-4dannjjm 4292 30 . . . cord-023095-4dannjjm 4293 1 Voiding void VBG cord-023095-4dannjjm 4293 2 urohydropropulsion urohydropropulsion NN cord-023095-4dannjjm 4293 3 is be VBZ cord-023095-4dannjjm 4293 4 a a DT cord-023095-4dannjjm 4293 5 non non JJ cord-023095-4dannjjm 4293 6 - - JJ cord-023095-4dannjjm 4293 7 invasive invasive JJ cord-023095-4dannjjm 4293 8 method method NN cord-023095-4dannjjm 4293 9 for for IN cord-023095-4dannjjm 4293 10 removing remove VBG cord-023095-4dannjjm 4293 11 small small JJ cord-023095-4dannjjm 4293 12 urocystoliths urocystolith NNS cord-023095-4dannjjm 4293 13 from from IN cord-023095-4dannjjm 4293 14 the the DT cord-023095-4dannjjm 4293 15 dog dog NN cord-023095-4dannjjm 4293 16 , , , cord-023095-4dannjjm 4293 17 most most RBS cord-023095-4dannjjm 4293 18 commonly commonly RB cord-023095-4dannjjm 4293 19 used use VBN cord-023095-4dannjjm 4293 20 in in IN cord-023095-4dannjjm 4293 21 females female NNS cord-023095-4dannjjm 4293 22 due due JJ cord-023095-4dannjjm 4293 23 to to IN cord-023095-4dannjjm 4293 24 the the DT cord-023095-4dannjjm 4293 25 relatively relatively RB cord-023095-4dannjjm 4293 26 wider wide JJR cord-023095-4dannjjm 4293 27 and and CC cord-023095-4dannjjm 4293 28 shorter short JJR cord-023095-4dannjjm 4293 29 urethra urethra NN cord-023095-4dannjjm 4293 30 . . . cord-023095-4dannjjm 4294 1 This this DT cord-023095-4dannjjm 4294 2 procedure procedure NN cord-023095-4dannjjm 4294 3 is be VBZ cord-023095-4dannjjm 4294 4 typically typically RB cord-023095-4dannjjm 4294 5 performed perform VBN cord-023095-4dannjjm 4294 6 under under IN cord-023095-4dannjjm 4294 7 general general JJ cord-023095-4dannjjm 4294 8 anesthesia anesthesia NNP cord-023095-4dannjjm 4294 9 to to TO cord-023095-4dannjjm 4294 10 allow allow VB cord-023095-4dannjjm 4294 11 complete complete JJ cord-023095-4dannjjm 4294 12 relaxation relaxation NN cord-023095-4dannjjm 4294 13 of of IN cord-023095-4dannjjm 4294 14 the the DT cord-023095-4dannjjm 4294 15 urethra urethra NN cord-023095-4dannjjm 4294 16 , , , cord-023095-4dannjjm 4294 17 however however RB cord-023095-4dannjjm 4294 18 , , , cord-023095-4dannjjm 4294 19 anesthesia anesthesia NN cord-023095-4dannjjm 4294 20 results result NNS cord-023095-4dannjjm 4294 21 in in IN cord-023095-4dannjjm 4294 22 longer long JJR cord-023095-4dannjjm 4294 23 procedure procedure NN cord-023095-4dannjjm 4294 24 times time NNS cord-023095-4dannjjm 4294 25 and and CC cord-023095-4dannjjm 4294 26 difficult difficult JJ cord-023095-4dannjjm 4294 27 endotracheal endotracheal NN cord-023095-4dannjjm 4294 28 tube tube NN cord-023095-4dannjjm 4294 29 stabilization stabilization NN cord-023095-4dannjjm 4294 30 due due IN cord-023095-4dannjjm 4294 31 to to IN cord-023095-4dannjjm 4294 32 the the DT cord-023095-4dannjjm 4294 33 vertical vertical JJ cord-023095-4dannjjm 4294 34 positioning positioning NN cord-023095-4dannjjm 4294 35 of of IN cord-023095-4dannjjm 4294 36 animals animal NNS cord-023095-4dannjjm 4294 37 , , , cord-023095-4dannjjm 4294 38 especially especially RB cord-023095-4dannjjm 4294 39 in in IN cord-023095-4dannjjm 4294 40 larger large JJR cord-023095-4dannjjm 4294 41 dogs dog NNS cord-023095-4dannjjm 4294 42 . . . cord-023095-4dannjjm 4295 1 The the DT cord-023095-4dannjjm 4295 2 aim aim NN cord-023095-4dannjjm 4295 3 of of IN cord-023095-4dannjjm 4295 4 this this DT cord-023095-4dannjjm 4295 5 study study NN cord-023095-4dannjjm 4295 6 was be VBD cord-023095-4dannjjm 4295 7 to to TO cord-023095-4dannjjm 4295 8 devise devise VB cord-023095-4dannjjm 4295 9 a a DT cord-023095-4dannjjm 4295 10 novel novel JJ cord-023095-4dannjjm 4295 11 injectable injectable JJ cord-023095-4dannjjm 4295 12 sedation sedation NN cord-023095-4dannjjm 4295 13 protocol protocol NN cord-023095-4dannjjm 4295 14 for for IN cord-023095-4dannjjm 4295 15 urohydropropulsion urohydropropulsion NN cord-023095-4dannjjm 4295 16 when when WRB cord-023095-4dannjjm 4295 17 cystoscopy cystoscopy NN cord-023095-4dannjjm 4295 18 was be VBD cord-023095-4dannjjm 4295 19 not not RB cord-023095-4dannjjm 4295 20 concurrently concurrently RB cord-023095-4dannjjm 4295 21 required require VBN cord-023095-4dannjjm 4295 22 . . . cord-023095-4dannjjm 4296 1 An an DT cord-023095-4dannjjm 4296 2 intravenous intravenous JJ cord-023095-4dannjjm 4296 3 catheter catheter NN cord-023095-4dannjjm 4296 4 was be VBD cord-023095-4dannjjm 4296 5 placed place VBN cord-023095-4dannjjm 4296 6 , , , cord-023095-4dannjjm 4296 7 and and CC cord-023095-4dannjjm 4296 8 a a DT cord-023095-4dannjjm 4296 9 combination combination NN cord-023095-4dannjjm 4296 10 of of IN cord-023095-4dannjjm 4296 11 medetomidine medetomidine NN cord-023095-4dannjjm 4296 12 ( ( -LRB- cord-023095-4dannjjm 4296 13 10 10 CD cord-023095-4dannjjm 4296 14 to to TO cord-023095-4dannjjm 4296 15 15 15 CD cord-023095-4dannjjm 4296 16 mg mg NNP cord-023095-4dannjjm 4296 17 / / SYM cord-023095-4dannjjm 4296 18 kg kg NNP cord-023095-4dannjjm 4296 19 IV IV NNP cord-023095-4dannjjm 4296 20 ) ) -RRB- cord-023095-4dannjjm 4296 21 and and CC cord-023095-4dannjjm 4296 22 hydromorphone hydromorphone NN cord-023095-4dannjjm 4296 23 ( ( -LRB- cord-023095-4dannjjm 4296 24 0.025 0.025 CD cord-023095-4dannjjm 4296 25 to to TO cord-023095-4dannjjm 4296 26 0.05 0.05 CD cord-023095-4dannjjm 4296 27 mg mg NNP cord-023095-4dannjjm 4296 28 / / SYM cord-023095-4dannjjm 4296 29 kg kg NNP cord-023095-4dannjjm 4296 30 IV IV NNP cord-023095-4dannjjm 4296 31 ) ) -RRB- cord-023095-4dannjjm 4296 32 was be VBD cord-023095-4dannjjm 4296 33 administered administer VBN cord-023095-4dannjjm 4296 34 , , , cord-023095-4dannjjm 4296 35 with with IN cord-023095-4dannjjm 4296 36 the the DT cord-023095-4dannjjm 4296 37 addition addition NN cord-023095-4dannjjm 4296 38 of of IN cord-023095-4dannjjm 4296 39 ketamine ketamine NNP cord-023095-4dannjjm 4296 40 ( ( -LRB- cord-023095-4dannjjm 4296 41 2 2 CD cord-023095-4dannjjm 4296 42 mg/ mg/ NN cord-023095-4dannjjm 4296 43 kg kg NNP cord-023095-4dannjjm 4296 44 IV IV NNP cord-023095-4dannjjm 4296 45 ) ) -RRB- cord-023095-4dannjjm 4296 46 in in IN cord-023095-4dannjjm 4296 47 fractious fractious JJ cord-023095-4dannjjm 4296 48 animals animal NNS cord-023095-4dannjjm 4296 49 ; ; : cord-023095-4dannjjm 4296 50 atipamezole atipamezole NNP cord-023095-4dannjjm 4296 51 ( ( -LRB- cord-023095-4dannjjm 4296 52 double double JJ cord-023095-4dannjjm 4296 53 volume volume NN cord-023095-4dannjjm 4296 54 of of IN cord-023095-4dannjjm 4296 55 medetomidine medetomidine NN cord-023095-4dannjjm 4296 56 , , , cord-023095-4dannjjm 4296 57 administered administer VBN cord-023095-4dannjjm 4296 58 IM IM NNP cord-023095-4dannjjm 4296 59 ) ) -RRB- cord-023095-4dannjjm 4296 60 was be VBD cord-023095-4dannjjm 4296 61 used use VBN cord-023095-4dannjjm 4296 62 as as IN cord-023095-4dannjjm 4296 63 a a DT cord-023095-4dannjjm 4296 64 reversal reversal NN cord-023095-4dannjjm 4296 65 agent agent NN cord-023095-4dannjjm 4296 66 upon upon IN cord-023095-4dannjjm 4296 67 procedure procedure NN cord-023095-4dannjjm 4296 68 completion completion NN cord-023095-4dannjjm 4296 69 . . . cord-023095-4dannjjm 4297 1 This this DT cord-023095-4dannjjm 4297 2 protocol protocol NN cord-023095-4dannjjm 4297 3 was be VBD cord-023095-4dannjjm 4297 4 considered consider VBN cord-023095-4dannjjm 4297 5 in in IN cord-023095-4dannjjm 4297 6 cardiovascularly cardiovascularly RB cord-023095-4dannjjm 4297 7 healthy healthy JJ cord-023095-4dannjjm 4297 8 , , , cord-023095-4dannjjm 4297 9 non non JJ cord-023095-4dannjjm 4297 10 - - JJ cord-023095-4dannjjm 4297 11 diabetic diabetic JJ cord-023095-4dannjjm 4297 12 dogs dog NNS cord-023095-4dannjjm 4297 13 without without IN cord-023095-4dannjjm 4297 14 evidence evidence NN cord-023095-4dannjjm 4297 15 of of IN cord-023095-4dannjjm 4297 16 urinary urinary JJ cord-023095-4dannjjm 4297 17 obstruction obstruction NN cord-023095-4dannjjm 4297 18 . . . cord-023095-4dannjjm 4298 1 Monitoring monitoring NN cord-023095-4dannjjm 4298 2 equipment equipment NN cord-023095-4dannjjm 4298 3 included include VBD cord-023095-4dannjjm 4298 4 electrocardiography electrocardiography NN cord-023095-4dannjjm 4298 5 , , , cord-023095-4dannjjm 4298 6 blood blood NN cord-023095-4dannjjm 4298 7 pressure pressure NN cord-023095-4dannjjm 4298 8 measurement measurement NN cord-023095-4dannjjm 4298 9 , , , cord-023095-4dannjjm 4298 10 and and CC cord-023095-4dannjjm 4298 11 pulse pulse NN cord-023095-4dannjjm 4298 12 oximetry oximetry NN cord-023095-4dannjjm 4298 13 , , , cord-023095-4dannjjm 4298 14 and and CC cord-023095-4dannjjm 4298 15 supplemental supplemental JJ cord-023095-4dannjjm 4298 16 flowby flowby NN cord-023095-4dannjjm 4298 17 oxygen oxygen NN cord-023095-4dannjjm 4298 18 was be VBD cord-023095-4dannjjm 4298 19 provided provide VBN cord-023095-4dannjjm 4298 20 . . . cord-023095-4dannjjm 4299 1 Two two CD cord-023095-4dannjjm 4299 2 dogs dog NNS cord-023095-4dannjjm 4299 3 received receive VBD cord-023095-4dannjjm 4299 4 the the DT cord-023095-4dannjjm 4299 5 proposed propose VBN cord-023095-4dannjjm 4299 6 sedation sedation NN cord-023095-4dannjjm 4299 7 protocol protocol NN cord-023095-4dannjjm 4299 8 in in IN cord-023095-4dannjjm 4299 9 order order NN cord-023095-4dannjjm 4299 10 to to TO cord-023095-4dannjjm 4299 11 perform perform VB cord-023095-4dannjjm 4299 12 urohydropropulsion urohydropropulsion NN cord-023095-4dannjjm 4299 13 . . . cord-023095-4dannjjm 4300 1 Dog dog NN cord-023095-4dannjjm 4300 2 one one CD cord-023095-4dannjjm 4300 3 was be VBD cord-023095-4dannjjm 4300 4 a a DT cord-023095-4dannjjm 4300 5 3 3 CD cord-023095-4dannjjm 4300 6 year year NN cord-023095-4dannjjm 4300 7 old old JJ cord-023095-4dannjjm 4300 8 female female NN cord-023095-4dannjjm 4300 9 spayed spay VBN cord-023095-4dannjjm 4300 10 Shih Shih NNP cord-023095-4dannjjm 4300 11 Tzu Tzu NNP cord-023095-4dannjjm 4300 12 cross cross NN cord-023095-4dannjjm 4300 13 , , , cord-023095-4dannjjm 4300 14 and and CC cord-023095-4dannjjm 4300 15 dog dog NN cord-023095-4dannjjm 4300 16 2 2 CD cord-023095-4dannjjm 4300 17 was be VBD cord-023095-4dannjjm 4300 18 a a DT cord-023095-4dannjjm 4300 19 2 2 CD cord-023095-4dannjjm 4300 20 year year NN cord-023095-4dannjjm 4300 21 old old JJ cord-023095-4dannjjm 4300 22 female female NN cord-023095-4dannjjm 4300 23 spayed spay VBN cord-023095-4dannjjm 4300 24 Standard Standard NNP cord-023095-4dannjjm 4300 25 Poodle Poodle NNP cord-023095-4dannjjm 4300 26 . . . cord-023095-4dannjjm 4301 1 Ultrasonography Ultrasonography NNP cord-023095-4dannjjm 4301 2 revealed reveal VBD cord-023095-4dannjjm 4301 3 a a DT cord-023095-4dannjjm 4301 4 moderate moderate JJ cord-023095-4dannjjm 4301 5 number number NN cord-023095-4dannjjm 4301 6 of of IN cord-023095-4dannjjm 4301 7 urocystoliths urocystolith NNS cord-023095-4dannjjm 4301 8 present present JJ cord-023095-4dannjjm 4301 9 in in IN cord-023095-4dannjjm 4301 10 both both DT cord-023095-4dannjjm 4301 11 dogs dog NNS cord-023095-4dannjjm 4301 12 , , , cord-023095-4dannjjm 4301 13 measuring measure VBG cord-023095-4dannjjm 4301 14 up up IN cord-023095-4dannjjm 4301 15 to to TO cord-023095-4dannjjm 4301 16 1 1 CD cord-023095-4dannjjm 4301 17 mm mm NN cord-023095-4dannjjm 4301 18 in in IN cord-023095-4dannjjm 4301 19 dog dog NN cord-023095-4dannjjm 4301 20 1 1 CD cord-023095-4dannjjm 4301 21 and and CC cord-023095-4dannjjm 4301 22 2.3 2.3 CD cord-023095-4dannjjm 4301 23 mm mm NNS cord-023095-4dannjjm 4301 24 in in IN cord-023095-4dannjjm 4301 25 dog dog NN cord-023095-4dannjjm 4301 26 2 2 CD cord-023095-4dannjjm 4301 27 . . . cord-023095-4dannjjm 4302 1 Urohydropropulsion Urohydropropulsion NNP cord-023095-4dannjjm 4302 2 was be VBD cord-023095-4dannjjm 4302 3 performed perform VBN cord-023095-4dannjjm 4302 4 and and CC cord-023095-4dannjjm 4302 5 resulted result VBN cord-023095-4dannjjm 4302 6 in in IN cord-023095-4dannjjm 4302 7 retrieval retrieval NN cord-023095-4dannjjm 4302 8 of of IN cord-023095-4dannjjm 4302 9 15 15 CD cord-023095-4dannjjm 4302 10 urocystoliths urocystolith NNS cord-023095-4dannjjm 4302 11 in in IN cord-023095-4dannjjm 4302 12 dog dog NN cord-023095-4dannjjm 4302 13 1 1 CD cord-023095-4dannjjm 4302 14 , , , cord-023095-4dannjjm 4302 15 and and CC cord-023095-4dannjjm 4302 16 approximately approximately RB cord-023095-4dannjjm 4302 17 20 20 CD cord-023095-4dannjjm 4302 18 urocystoliths urocystolith NNS cord-023095-4dannjjm 4302 19 in in IN cord-023095-4dannjjm 4302 20 dog dog NN cord-023095-4dannjjm 4302 21 2 2 CD cord-023095-4dannjjm 4302 22 . . . cord-023095-4dannjjm 4303 1 Repeat repeat NN cord-023095-4dannjjm 4303 2 ultrasonography ultrasonography NN cord-023095-4dannjjm 4303 3 revealed reveal VBD cord-023095-4dannjjm 4303 4 no no DT cord-023095-4dannjjm 4303 5 uroliths uroliths JJ cord-023095-4dannjjm 4303 6 present present JJ cord-023095-4dannjjm 4303 7 after after IN cord-023095-4dannjjm 4303 8 urohydropropulsion urohydropropulsion NN cord-023095-4dannjjm 4303 9 in in IN cord-023095-4dannjjm 4303 10 both both DT cord-023095-4dannjjm 4303 11 dogs dog NNS cord-023095-4dannjjm 4303 12 . . . cord-023095-4dannjjm 4304 1 The the DT cord-023095-4dannjjm 4304 2 time time NN cord-023095-4dannjjm 4304 3 from from IN cord-023095-4dannjjm 4304 4 administration administration NN cord-023095-4dannjjm 4304 5 of of IN cord-023095-4dannjjm 4304 6 sedation sedation NN cord-023095-4dannjjm 4304 7 to to IN cord-023095-4dannjjm 4304 8 administration administration NN cord-023095-4dannjjm 4304 9 of of IN cord-023095-4dannjjm 4304 10 reversal reversal NN cord-023095-4dannjjm 4304 11 agent agent NN cord-023095-4dannjjm 4304 12 was be VBD cord-023095-4dannjjm 4304 13 6 6 CD cord-023095-4dannjjm 4304 14 minutes minute NNS cord-023095-4dannjjm 4304 15 for for IN cord-023095-4dannjjm 4304 16 dog dog NN cord-023095-4dannjjm 4304 17 1 1 CD cord-023095-4dannjjm 4304 18 , , , cord-023095-4dannjjm 4304 19 and and CC cord-023095-4dannjjm 4304 20 8.5 8.5 CD cord-023095-4dannjjm 4304 21 minutes minute NNS cord-023095-4dannjjm 4304 22 for for IN cord-023095-4dannjjm 4304 23 dog dog NN cord-023095-4dannjjm 4304 24 2 2 CD cord-023095-4dannjjm 4304 25 . . . cord-023095-4dannjjm 4305 1 Records record NNS cord-023095-4dannjjm 4305 2 were be VBD cord-023095-4dannjjm 4305 3 obtained obtain VBN cord-023095-4dannjjm 4305 4 from from IN cord-023095-4dannjjm 4305 5 3 3 CD cord-023095-4dannjjm 4305 6 dogs dog NNS cord-023095-4dannjjm 4305 7 that that WDT cord-023095-4dannjjm 4305 8 had have VBD cord-023095-4dannjjm 4305 9 traditional traditional JJ cord-023095-4dannjjm 4305 10 general general JJ cord-023095-4dannjjm 4305 11 anesthetic anesthetic JJ cord-023095-4dannjjm 4305 12 protocols protocol NNS cord-023095-4dannjjm 4305 13 for for IN cord-023095-4dannjjm 4305 14 urohydropropulsion urohydropropulsion NN cord-023095-4dannjjm 4305 15 with with IN cord-023095-4dannjjm 4305 16 cystoscopy cystoscopy NN cord-023095-4dannjjm 4305 17 for for IN cord-023095-4dannjjm 4305 18 confirmation confirmation NN cord-023095-4dannjjm 4305 19 of of IN cord-023095-4dannjjm 4305 20 urocystolith urocystolith NNP cord-023095-4dannjjm 4305 21 removal removal NN cord-023095-4dannjjm 4305 22 , , , cord-023095-4dannjjm 4305 23 performed perform VBN cord-023095-4dannjjm 4305 24 within within IN cord-023095-4dannjjm 4305 25 the the DT cord-023095-4dannjjm 4305 26 last last JJ cord-023095-4dannjjm 4305 27 2 2 CD cord-023095-4dannjjm 4305 28 years year NNS cord-023095-4dannjjm 4305 29 , , , cord-023095-4dannjjm 4305 30 and and CC cord-023095-4dannjjm 4305 31 the the DT cord-023095-4dannjjm 4305 32 average average JJ cord-023095-4dannjjm 4305 33 anesthetic anesthetic JJ cord-023095-4dannjjm 4305 34 time time NN cord-023095-4dannjjm 4305 35 was be VBD cord-023095-4dannjjm 4305 36 64 64 CD cord-023095-4dannjjm 4305 37 minutes minute NNS cord-023095-4dannjjm 4305 38 . . . cord-023095-4dannjjm 4306 1 Subsequent subsequent JJ cord-023095-4dannjjm 4306 2 to to IN cord-023095-4dannjjm 4306 3 the the DT cord-023095-4dannjjm 4306 4 use use NN cord-023095-4dannjjm 4306 5 of of IN cord-023095-4dannjjm 4306 6 medetomine medetomine NN cord-023095-4dannjjm 4306 7 - - HYPH cord-023095-4dannjjm 4306 8 based base VBN cord-023095-4dannjjm 4306 9 sedation sedation NN cord-023095-4dannjjm 4306 10 protocols protocol NNS cord-023095-4dannjjm 4306 11 for for IN cord-023095-4dannjjm 4306 12 the the DT cord-023095-4dannjjm 4306 13 above above JJ cord-023095-4dannjjm 4306 14 dogs dog NNS cord-023095-4dannjjm 4306 15 , , , cord-023095-4dannjjm 4306 16 cystoscopy cystoscopy NN cord-023095-4dannjjm 4306 17 was be VBD cord-023095-4dannjjm 4306 18 performed perform VBN cord-023095-4dannjjm 4306 19 in in IN cord-023095-4dannjjm 4306 20 a a DT cord-023095-4dannjjm 4306 21 9 9 CD cord-023095-4dannjjm 4306 22 year year NN cord-023095-4dannjjm 4306 23 old old JJ cord-023095-4dannjjm 4306 24 neutered neutered JJ cord-023095-4dannjjm 4306 25 male male JJ cord-023095-4dannjjm 4306 26 Golden Golden NNP cord-023095-4dannjjm 4306 27 Retriever Retriever NNP cord-023095-4dannjjm 4306 28 with with IN cord-023095-4dannjjm 4306 29 prostatomegaly prostatomegaly NNP cord-023095-4dannjjm 4306 30 . . . cord-023095-4dannjjm 4307 1 Medetomidine Medetomidine NNP cord-023095-4dannjjm 4307 2 ( ( -LRB- cord-023095-4dannjjm 4307 3 15 15 CD cord-023095-4dannjjm 4307 4 ug ug NNP cord-023095-4dannjjm 4307 5 / / SYM cord-023095-4dannjjm 4307 6 kg kg NNP cord-023095-4dannjjm 4307 7 IV IV NNP cord-023095-4dannjjm 4307 8 ) ) -RRB- cord-023095-4dannjjm 4307 9 and and CC cord-023095-4dannjjm 4307 10 butorphanol butorphanol NNP cord-023095-4dannjjm 4307 11 ( ( -LRB- cord-023095-4dannjjm 4307 12 0.2 0.2 CD cord-023095-4dannjjm 4307 13 mg mg NNP cord-023095-4dannjjm 4307 14 / / SYM cord-023095-4dannjjm 4307 15 kg kg NNP cord-023095-4dannjjm 4307 16 IV IV NNP cord-023095-4dannjjm 4307 17 ) ) -RRB- cord-023095-4dannjjm 4307 18 were be VBD cord-023095-4dannjjm 4307 19 administered administer VBN cord-023095-4dannjjm 4307 20 ; ; : cord-023095-4dannjjm 4307 21 atipamezole atipamezole NNP cord-023095-4dannjjm 4307 22 ( ( -LRB- cord-023095-4dannjjm 4307 23 double double JJ cord-023095-4dannjjm 4307 24 volume volume NN cord-023095-4dannjjm 4307 25 of of IN cord-023095-4dannjjm 4307 26 medetomidine medetomidine NN cord-023095-4dannjjm 4307 27 , , , cord-023095-4dannjjm 4307 28 administered administer VBN cord-023095-4dannjjm 4307 29 IM IM NNP cord-023095-4dannjjm 4307 30 ) ) -RRB- cord-023095-4dannjjm 4307 31 was be VBD cord-023095-4dannjjm 4307 32 used use VBN cord-023095-4dannjjm 4307 33 as as IN cord-023095-4dannjjm 4307 34 a a DT cord-023095-4dannjjm 4307 35 reversal reversal NN cord-023095-4dannjjm 4307 36 agent agent NN cord-023095-4dannjjm 4307 37 upon upon IN cord-023095-4dannjjm 4307 38 procedure procedure NN cord-023095-4dannjjm 4307 39 completion completion NN cord-023095-4dannjjm 4307 40 . . . cord-023095-4dannjjm 4308 1 This this DT cord-023095-4dannjjm 4308 2 sedation sedation NN cord-023095-4dannjjm 4308 3 allowed allow VBD cord-023095-4dannjjm 4308 4 adequate adequate JJ cord-023095-4dannjjm 4308 5 immobilization immobilization NN cord-023095-4dannjjm 4308 6 for for IN cord-023095-4dannjjm 4308 7 cystoscopy cystoscopy NN cord-023095-4dannjjm 4308 8 of of IN cord-023095-4dannjjm 4308 9 the the DT cord-023095-4dannjjm 4308 10 urethra urethra NN cord-023095-4dannjjm 4308 11 and and CC cord-023095-4dannjjm 4308 12 urinary urinary JJ cord-023095-4dannjjm 4308 13 bladder bladder NN cord-023095-4dannjjm 4308 14 , , , cord-023095-4dannjjm 4308 15 and and CC cord-023095-4dannjjm 4308 16 endoscopic endoscopic NNS cord-023095-4dannjjm 4308 17 biopsying biopsying NN cord-023095-4dannjjm 4308 18 of of IN cord-023095-4dannjjm 4308 19 the the DT cord-023095-4dannjjm 4308 20 prostatic prostatic JJ cord-023095-4dannjjm 4308 21 urethra urethra NN cord-023095-4dannjjm 4308 22 and and CC cord-023095-4dannjjm 4308 23 urinary urinary JJ cord-023095-4dannjjm 4308 24 bladder bladder NN cord-023095-4dannjjm 4308 25 . . . cord-023095-4dannjjm 4309 1 The the DT cord-023095-4dannjjm 4309 2 time time NN cord-023095-4dannjjm 4309 3 from from IN cord-023095-4dannjjm 4309 4 administration administration NN cord-023095-4dannjjm 4309 5 of of IN cord-023095-4dannjjm 4309 6 sedation sedation NN cord-023095-4dannjjm 4309 7 to to IN cord-023095-4dannjjm 4309 8 administration administration NN cord-023095-4dannjjm 4309 9 of of IN cord-023095-4dannjjm 4309 10 reversal reversal NN cord-023095-4dannjjm 4309 11 agent agent NN cord-023095-4dannjjm 4309 12 was be VBD cord-023095-4dannjjm 4309 13 15 15 CD cord-023095-4dannjjm 4309 14 minutes minute NNS cord-023095-4dannjjm 4309 15 for for IN cord-023095-4dannjjm 4309 16 this this DT cord-023095-4dannjjm 4309 17 dog dog NN cord-023095-4dannjjm 4309 18 . . . cord-023095-4dannjjm 4310 1 In in IN cord-023095-4dannjjm 4310 2 conclusion conclusion NN cord-023095-4dannjjm 4310 3 , , , cord-023095-4dannjjm 4310 4 a a DT cord-023095-4dannjjm 4310 5 novel novel JJ cord-023095-4dannjjm 4310 6 sedative sedative NN cord-023095-4dannjjm 4310 7 protocol protocol NN cord-023095-4dannjjm 4310 8 for for IN cord-023095-4dannjjm 4310 9 urohydropropulsion urohydropropulsion NN cord-023095-4dannjjm 4310 10 is be VBZ cord-023095-4dannjjm 4310 11 proposed propose VBN cord-023095-4dannjjm 4310 12 which which WDT cord-023095-4dannjjm 4310 13 allows allow VBZ cord-023095-4dannjjm 4310 14 for for IN cord-023095-4dannjjm 4310 15 an an DT cord-023095-4dannjjm 4310 16 appropriate appropriate JJ cord-023095-4dannjjm 4310 17 level level NN cord-023095-4dannjjm 4310 18 of of IN cord-023095-4dannjjm 4310 19 sedation sedation NN cord-023095-4dannjjm 4310 20 along along IN cord-023095-4dannjjm 4310 21 with with IN cord-023095-4dannjjm 4310 22 a a DT cord-023095-4dannjjm 4310 23 short short JJ cord-023095-4dannjjm 4310 24 procedure procedure NN cord-023095-4dannjjm 4310 25 time time NN cord-023095-4dannjjm 4310 26 and and CC cord-023095-4dannjjm 4310 27 rapid rapid JJ cord-023095-4dannjjm 4310 28 recovery recovery NN cord-023095-4dannjjm 4310 29 . . . cord-023095-4dannjjm 4311 1 This this DT cord-023095-4dannjjm 4311 2 sedation sedation NN cord-023095-4dannjjm 4311 3 protocol protocol NN cord-023095-4dannjjm 4311 4 may may MD cord-023095-4dannjjm 4311 5 also also RB cord-023095-4dannjjm 4311 6 be be VB cord-023095-4dannjjm 4311 7 useful useful JJ cord-023095-4dannjjm 4311 8 for for IN cord-023095-4dannjjm 4311 9 certain certain JJ cord-023095-4dannjjm 4311 10 cystoscopic cystoscopic JJ cord-023095-4dannjjm 4311 11 procedures procedure NNS cord-023095-4dannjjm 4311 12 . . . cord-023095-4dannjjm 4312 1 analysis analysis NN cord-023095-4dannjjm 4312 2 may may MD cord-023095-4dannjjm 4312 3 be be VB cord-023095-4dannjjm 4312 4 delayed delay VBN cord-023095-4dannjjm 4312 5 for for IN cord-023095-4dannjjm 4312 6 a a DT cord-023095-4dannjjm 4312 7 variety variety NN cord-023095-4dannjjm 4312 8 of of IN cord-023095-4dannjjm 4312 9 reasons reason NNS cord-023095-4dannjjm 4312 10 , , , cord-023095-4dannjjm 4312 11 including include VBG cord-023095-4dannjjm 4312 12 the the DT cord-023095-4dannjjm 4312 13 need need NN cord-023095-4dannjjm 4312 14 for for IN cord-023095-4dannjjm 4312 15 sample sample NN cord-023095-4dannjjm 4312 16 batching batching NN cord-023095-4dannjjm 4312 17 within within IN cord-023095-4dannjjm 4312 18 the the DT cord-023095-4dannjjm 4312 19 laboratory laboratory NN cord-023095-4dannjjm 4312 20 or or CC cord-023095-4dannjjm 4312 21 shipping ship VBG cord-023095-4dannjjm 4312 22 to to IN cord-023095-4dannjjm 4312 23 an an DT cord-023095-4dannjjm 4312 24 outsourced outsource VBN cord-023095-4dannjjm 4312 25 location location NN cord-023095-4dannjjm 4312 26 . . . cord-023095-4dannjjm 4313 1 Therefore therefore RB cord-023095-4dannjjm 4313 2 , , , cord-023095-4dannjjm 4313 3 it -PRON- PRP cord-023095-4dannjjm 4313 4 is be VBZ cord-023095-4dannjjm 4313 5 important important JJ cord-023095-4dannjjm 4313 6 to to TO cord-023095-4dannjjm 4313 7 know know VB cord-023095-4dannjjm 4313 8 how how WRB cord-023095-4dannjjm 4313 9 storage storage NN cord-023095-4dannjjm 4313 10 of of IN cord-023095-4dannjjm 4313 11 the the DT cord-023095-4dannjjm 4313 12 sample sample NN cord-023095-4dannjjm 4313 13 may may MD cord-023095-4dannjjm 4313 14 affect affect VB cord-023095-4dannjjm 4313 15 enzyme enzyme NN cord-023095-4dannjjm 4313 16 activity activity NN cord-023095-4dannjjm 4313 17 . . . cord-023095-4dannjjm 4314 1 We -PRON- PRP cord-023095-4dannjjm 4314 2 hypothesized hypothesize VBD cord-023095-4dannjjm 4314 3 that that IN cord-023095-4dannjjm 4314 4 urinary urinary JJ cord-023095-4dannjjm 4314 5 NAG NAG NNP cord-023095-4dannjjm 4314 6 and and CC cord-023095-4dannjjm 4314 7 GGT GGT NNP cord-023095-4dannjjm 4314 8 activity activity NN cord-023095-4dannjjm 4314 9 would would MD cord-023095-4dannjjm 4314 10 be be VB cord-023095-4dannjjm 4314 11 affected affect VBN cord-023095-4dannjjm 4314 12 differently differently RB cord-023095-4dannjjm 4314 13 in in IN cord-023095-4dannjjm 4314 14 samples sample NNS cord-023095-4dannjjm 4314 15 stored store VBN cord-023095-4dannjjm 4314 16 by by IN cord-023095-4dannjjm 4314 17 refrigeration refrigeration NN cord-023095-4dannjjm 4314 18 vs. vs. FW cord-023095-4dannjjm 4314 19 freezing freezing NN cord-023095-4dannjjm 4314 20 . . . cord-023095-4dannjjm 4315 1 Thirty thirty CD cord-023095-4dannjjm 4315 2 - - HYPH cord-023095-4dannjjm 4315 3 four four CD cord-023095-4dannjjm 4315 4 canine canine JJ cord-023095-4dannjjm 4315 5 urine urine NN cord-023095-4dannjjm 4315 6 samples sample NNS cord-023095-4dannjjm 4315 7 submitted submit VBN cord-023095-4dannjjm 4315 8 to to IN cord-023095-4dannjjm 4315 9 the the DT cord-023095-4dannjjm 4315 10 Clinical Clinical NNP cord-023095-4dannjjm 4315 11 Pathology Pathology NNP cord-023095-4dannjjm 4315 12 Laboratory Laboratory NNP cord-023095-4dannjjm 4315 13 at at IN cord-023095-4dannjjm 4315 14 Kansas Kansas NNP cord-023095-4dannjjm 4315 15 State State NNP cord-023095-4dannjjm 4315 16 University University NNP cord-023095-4dannjjm 4315 17 were be VBD cord-023095-4dannjjm 4315 18 included include VBN cord-023095-4dannjjm 4315 19 . . . cord-023095-4dannjjm 4316 1 Samples sample NNS cord-023095-4dannjjm 4316 2 were be VBD cord-023095-4dannjjm 4316 3 collected collect VBN cord-023095-4dannjjm 4316 4 from from IN cord-023095-4dannjjm 4316 5 clinical clinical JJ cord-023095-4dannjjm 4316 6 patients patient NNS cord-023095-4dannjjm 4316 7 with with IN cord-023095-4dannjjm 4316 8 a a DT cord-023095-4dannjjm 4316 9 variety variety NN cord-023095-4dannjjm 4316 10 of of IN cord-023095-4dannjjm 4316 11 medical medical JJ cord-023095-4dannjjm 4316 12 / / SYM cord-023095-4dannjjm 4316 13 surgical surgical JJ cord-023095-4dannjjm 4316 14 disorders disorder NNS cord-023095-4dannjjm 4316 15 and and CC cord-023095-4dannjjm 4316 16 were be VBD cord-023095-4dannjjm 4316 17 selected select VBN cord-023095-4dannjjm 4316 18 based base VBN cord-023095-4dannjjm 4316 19 on on IN cord-023095-4dannjjm 4316 20 the the DT cord-023095-4dannjjm 4316 21 day day NN cord-023095-4dannjjm 4316 22 of of IN cord-023095-4dannjjm 4316 23 the the DT cord-023095-4dannjjm 4316 24 week week NN cord-023095-4dannjjm 4316 25 and and CC cord-023095-4dannjjm 4316 26 a a DT cord-023095-4dannjjm 4316 27 minimum minimum JJ cord-023095-4dannjjm 4316 28 volume volume NN cord-023095-4dannjjm 4316 29 of of IN cord-023095-4dannjjm 4316 30 10 10 CD cord-023095-4dannjjm 4316 31 ml ml NNS cord-023095-4dannjjm 4316 32 . . . cord-023095-4dannjjm 4317 1 A a DT cord-023095-4dannjjm 4317 2 complete complete JJ cord-023095-4dannjjm 4317 3 urinalysis urinalysis NN cord-023095-4dannjjm 4317 4 was be VBD cord-023095-4dannjjm 4317 5 performed perform VBN cord-023095-4dannjjm 4317 6 on on IN cord-023095-4dannjjm 4317 7 each each DT cord-023095-4dannjjm 4317 8 sample sample NN cord-023095-4dannjjm 4317 9 ; ; : cord-023095-4dannjjm 4317 10 however however RB cord-023095-4dannjjm 4317 11 there there EX cord-023095-4dannjjm 4317 12 were be VBD cord-023095-4dannjjm 4317 13 no no DT cord-023095-4dannjjm 4317 14 exclusion exclusion NN cord-023095-4dannjjm 4317 15 criteria criterion NNS cord-023095-4dannjjm 4317 16 based base VBN cord-023095-4dannjjm 4317 17 on on IN cord-023095-4dannjjm 4317 18 urinalysis urinalysis NN cord-023095-4dannjjm 4317 19 results result NNS cord-023095-4dannjjm 4317 20 . . . cord-023095-4dannjjm 4318 1 NAG NAG NNP cord-023095-4dannjjm 4318 2 and and CC cord-023095-4dannjjm 4318 3 GGT GGT NNP cord-023095-4dannjjm 4318 4 activity activity NN cord-023095-4dannjjm 4318 5 in in IN cord-023095-4dannjjm 4318 6 the the DT cord-023095-4dannjjm 4318 7 urine urine NN cord-023095-4dannjjm 4318 8 supernatant supernatant NN cord-023095-4dannjjm 4318 9 was be VBD cord-023095-4dannjjm 4318 10 assessed assess VBN cord-023095-4dannjjm 4318 11 by by IN cord-023095-4dannjjm 4318 12 colorimetric colorimetric JJ cord-023095-4dannjjm 4318 13 assay assay NN cord-023095-4dannjjm 4318 14 . . . cord-023095-4dannjjm 4319 1 Aliquots aliquot NNS cord-023095-4dannjjm 4319 2 of of IN cord-023095-4dannjjm 4319 3 each each DT cord-023095-4dannjjm 4319 4 supernatant supernatant JJ cord-023095-4dannjjm 4319 5 were be VBD cord-023095-4dannjjm 4319 6 refrigerated refrigerate VBN cord-023095-4dannjjm 4319 7 for for IN cord-023095-4dannjjm 4319 8 5 5 CD cord-023095-4dannjjm 4319 9 days day NNS cord-023095-4dannjjm 4319 10 and and CC cord-023095-4dannjjm 4319 11 frozen freeze VBN cord-023095-4dannjjm 4319 12 at at IN cord-023095-4dannjjm 4319 13 À201C À201C NNPS cord-023095-4dannjjm 4319 14 for for IN cord-023095-4dannjjm 4319 15 5 5 CD cord-023095-4dannjjm 4319 16 and and CC cord-023095-4dannjjm 4319 17 30 30 CD cord-023095-4dannjjm 4319 18 days day NNS cord-023095-4dannjjm 4319 19 at at IN cord-023095-4dannjjm 4319 20 which which WDT cord-023095-4dannjjm 4319 21 time time NN cord-023095-4dannjjm 4319 22 enzyme enzyme NN cord-023095-4dannjjm 4319 23 activity activity NN cord-023095-4dannjjm 4319 24 was be VBD cord-023095-4dannjjm 4319 25 re re VBN cord-023095-4dannjjm 4319 26 - - VBN cord-023095-4dannjjm 4319 27 assessed assess VBN cord-023095-4dannjjm 4319 28 . . . cord-023095-4dannjjm 4320 1 Compared compare VBN cord-023095-4dannjjm 4320 2 to to IN cord-023095-4dannjjm 4320 3 baseline baseline JJ cord-023095-4dannjjm 4320 4 values value NNS cord-023095-4dannjjm 4320 5 , , , cord-023095-4dannjjm 4320 6 enzyme enzyme NN cord-023095-4dannjjm 4320 7 activity activity NN cord-023095-4dannjjm 4320 8 for for IN cord-023095-4dannjjm 4320 9 both both DT cord-023095-4dannjjm 4320 10 NAG NAG NNP cord-023095-4dannjjm 4320 11 and and CC cord-023095-4dannjjm 4320 12 GGT GGT NNP cord-023095-4dannjjm 4320 13 were be VBD cord-023095-4dannjjm 4320 14 stable stable JJ cord-023095-4dannjjm 4320 15 after after IN cord-023095-4dannjjm 4320 16 5 5 CD cord-023095-4dannjjm 4320 17 days day NNS cord-023095-4dannjjm 4320 18 of of IN cord-023095-4dannjjm 4320 19 refrigeration refrigeration NN cord-023095-4dannjjm 4320 20 , , , cord-023095-4dannjjm 4320 21 however however RB cord-023095-4dannjjm 4320 22 there there EX cord-023095-4dannjjm 4320 23 were be VBD cord-023095-4dannjjm 4320 24 significant significant JJ cord-023095-4dannjjm 4321 1 ( ( -LRB- cord-023095-4dannjjm 4321 2 P p NN cord-023095-4dannjjm 4321 3 o o NN cord-023095-4dannjjm 4321 4 0.01 0.01 CD cord-023095-4dannjjm 4321 5 ) ) -RRB- cord-023095-4dannjjm 4321 6 declines decline NNS cord-023095-4dannjjm 4321 7 in in IN cord-023095-4dannjjm 4321 8 GGT GGT NNP cord-023095-4dannjjm 4321 9 and and CC cord-023095-4dannjjm 4321 10 NAG NAG NNP cord-023095-4dannjjm 4321 11 activity activity NN cord-023095-4dannjjm 4321 12 when when WRB cord-023095-4dannjjm 4321 13 urine urine NN cord-023095-4dannjjm 4321 14 supernatants supernatant NNS cord-023095-4dannjjm 4321 15 were be VBD cord-023095-4dannjjm 4321 16 frozen freeze VBN cord-023095-4dannjjm 4321 17 for for IN cord-023095-4dannjjm 4321 18 5 5 CD cord-023095-4dannjjm 4321 19 and and CC cord-023095-4dannjjm 4321 20 30 30 CD cord-023095-4dannjjm 4321 21 days day NNS cord-023095-4dannjjm 4321 22 . . . cord-023095-4dannjjm 4322 1 Treatment treatment NN cord-023095-4dannjjm 4322 2 for for IN cord-023095-4dannjjm 4322 3 canine canine JJ cord-023095-4dannjjm 4322 4 urinary urinary JJ cord-023095-4dannjjm 4322 5 tract tract NN cord-023095-4dannjjm 4322 6 infections infection NNS cord-023095-4dannjjm 4322 7 ( ( -LRB- cord-023095-4dannjjm 4322 8 UTI UTI NNP cord-023095-4dannjjm 4322 9 ) ) -RRB- cord-023095-4dannjjm 4322 10 typically typically RB cord-023095-4dannjjm 4322 11 consists consist VBZ cord-023095-4dannjjm 4322 12 of of IN cord-023095-4dannjjm 4322 13 7 7 CD cord-023095-4dannjjm 4322 14 - - SYM cord-023095-4dannjjm 4322 15 14 14 CD cord-023095-4dannjjm 4322 16 days day NNS cord-023095-4dannjjm 4322 17 of of IN cord-023095-4dannjjm 4322 18 antimicrobial antimicrobial JJ cord-023095-4dannjjm 4322 19 drugs drug NNS cord-023095-4dannjjm 4322 20 in in IN cord-023095-4dannjjm 4322 21 primary primary JJ cord-023095-4dannjjm 4322 22 care care NN cord-023095-4dannjjm 4322 23 veterinary veterinary JJ cord-023095-4dannjjm 4322 24 practice practice NN cord-023095-4dannjjm 4322 25 . . . cord-023095-4dannjjm 4323 1 Compliance compliance NN cord-023095-4dannjjm 4323 2 with with IN cord-023095-4dannjjm 4323 3 this this DT cord-023095-4dannjjm 4323 4 drug drug NN cord-023095-4dannjjm 4323 5 regimen regimen NN cord-023095-4dannjjm 4323 6 can can MD cord-023095-4dannjjm 4323 7 be be VB cord-023095-4dannjjm 4323 8 difficult difficult JJ cord-023095-4dannjjm 4323 9 for for IN cord-023095-4dannjjm 4323 10 some some DT cord-023095-4dannjjm 4323 11 clients client NNS cord-023095-4dannjjm 4323 12 . . . cord-023095-4dannjjm 4324 1 Enrofloxacin Enrofloxacin NNP cord-023095-4dannjjm 4324 2 is be VBZ cord-023095-4dannjjm 4324 3 a a DT cord-023095-4dannjjm 4324 4 veterinary veterinary JJ cord-023095-4dannjjm 4324 5 approved approve VBN cord-023095-4dannjjm 4324 6 fluoroquinolone fluoroquinolone NN cord-023095-4dannjjm 4324 7 antimicrobial antimicrobial NN cord-023095-4dannjjm 4324 8 and and CC cord-023095-4dannjjm 4324 9 is be VBZ cord-023095-4dannjjm 4324 10 useful useful JJ cord-023095-4dannjjm 4324 11 for for IN cord-023095-4dannjjm 4324 12 treatment treatment NN cord-023095-4dannjjm 4324 13 of of IN cord-023095-4dannjjm 4324 14 canine canine JJ cord-023095-4dannjjm 4324 15 UTI UTI NNP cord-023095-4dannjjm 4324 16 . . . cord-023095-4dannjjm 4325 1 Fluoroquinolones fluoroquinolone NNS cord-023095-4dannjjm 4325 2 are be VBP cord-023095-4dannjjm 4325 3 often often RB cord-023095-4dannjjm 4325 4 used use VBN cord-023095-4dannjjm 4325 5 in in IN cord-023095-4dannjjm 4325 6 human human JJ cord-023095-4dannjjm 4325 7 medicine medicine NN cord-023095-4dannjjm 4325 8 to to TO cord-023095-4dannjjm 4325 9 treat treat VB cord-023095-4dannjjm 4325 10 uncomplicated uncomplicated JJ cord-023095-4dannjjm 4325 11 UTIs uti NNS cord-023095-4dannjjm 4325 12 in in IN cord-023095-4dannjjm 4325 13 women woman NNS cord-023095-4dannjjm 4325 14 and and CC cord-023095-4dannjjm 4325 15 can can MD cord-023095-4dannjjm 4325 16 be be VB cord-023095-4dannjjm 4325 17 prescribed prescribe VBN cord-023095-4dannjjm 4325 18 for for IN cord-023095-4dannjjm 4325 19 as as RB cord-023095-4dannjjm 4325 20 little little JJ cord-023095-4dannjjm 4325 21 as as IN cord-023095-4dannjjm 4325 22 3 3 CD cord-023095-4dannjjm 4325 23 days day NNS cord-023095-4dannjjm 4325 24 . . . cord-023095-4dannjjm 4326 1 The the DT cord-023095-4dannjjm 4326 2 primary primary JJ cord-023095-4dannjjm 4326 3 objective objective NN cord-023095-4dannjjm 4326 4 of of IN cord-023095-4dannjjm 4326 5 this this DT cord-023095-4dannjjm 4326 6 study study NN cord-023095-4dannjjm 4326 7 was be VBD cord-023095-4dannjjm 4326 8 to to TO cord-023095-4dannjjm 4326 9 determine determine VB cord-023095-4dannjjm 4326 10 if if IN cord-023095-4dannjjm 4326 11 dogs dog NNS cord-023095-4dannjjm 4326 12 with with IN cord-023095-4dannjjm 4326 13 naturally naturally RB cord-023095-4dannjjm 4326 14 occurring occur VBG cord-023095-4dannjjm 4326 15 uncomplicated uncomplicated JJ cord-023095-4dannjjm 4326 16 UTI UTI NNP cord-023095-4dannjjm 4326 17 have have VBP cord-023095-4dannjjm 4326 18 equivalent equivalent JJ cord-023095-4dannjjm 4326 19 microbiologic microbiologic JJ cord-023095-4dannjjm 4326 20 cure cure NN cord-023095-4dannjjm 4326 21 with with IN cord-023095-4dannjjm 4326 22 a a DT cord-023095-4dannjjm 4326 23 high high JJ cord-023095-4dannjjm 4326 24 dose dose NN cord-023095-4dannjjm 4326 25 short short JJ cord-023095-4dannjjm 4326 26 duration duration NN cord-023095-4dannjjm 4326 27 protocol protocol NN cord-023095-4dannjjm 4326 28 of of IN cord-023095-4dannjjm 4326 29 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 4326 30 , , , cord-023095-4dannjjm 4326 31 compared compare VBN cord-023095-4dannjjm 4326 32 to to IN cord-023095-4dannjjm 4326 33 a a DT cord-023095-4dannjjm 4326 34 standard standard JJ cord-023095-4dannjjm 4326 35 antimicrobial antimicrobial JJ cord-023095-4dannjjm 4326 36 protocol protocol NN cord-023095-4dannjjm 4326 37 . . . cord-023095-4dannjjm 4327 1 Client client NN cord-023095-4dannjjm 4327 2 - - HYPH cord-023095-4dannjjm 4327 3 owned own VBN cord-023095-4dannjjm 4327 4 adult adult NN cord-023095-4dannjjm 4327 5 dogs dog NNS cord-023095-4dannjjm 4327 6 with with IN cord-023095-4dannjjm 4327 7 naturally naturally RB cord-023095-4dannjjm 4327 8 occurring occur VBG cord-023095-4dannjjm 4327 9 , , , cord-023095-4dannjjm 4327 10 uncomplicated uncomplicated JJ cord-023095-4dannjjm 4327 11 UTI UTI NNP cord-023095-4dannjjm 4327 12 were be VBD cord-023095-4dannjjm 4327 13 prospectively prospectively RB cord-023095-4dannjjm 4327 14 enrolled enrol VBN cord-023095-4dannjjm 4327 15 in in IN cord-023095-4dannjjm 4327 16 a a DT cord-023095-4dannjjm 4327 17 multi multi JJ cord-023095-4dannjjm 4327 18 - - JJ cord-023095-4dannjjm 4327 19 center center JJ cord-023095-4dannjjm 4327 20 clinical clinical JJ cord-023095-4dannjjm 4327 21 trial trial NN cord-023095-4dannjjm 4327 22 and and CC cord-023095-4dannjjm 4327 23 assigned assign VBN cord-023095-4dannjjm 4327 24 to to IN cord-023095-4dannjjm 4327 25 1 1 CD cord-023095-4dannjjm 4327 26 of of IN cord-023095-4dannjjm 4327 27 2 2 CD cord-023095-4dannjjm 4327 28 groups group NNS cord-023095-4dannjjm 4327 29 in in IN cord-023095-4dannjjm 4327 30 a a DT cord-023095-4dannjjm 4327 31 randomized randomized JJ cord-023095-4dannjjm 4327 32 blinded blinded JJ cord-023095-4dannjjm 4327 33 manner manner NN cord-023095-4dannjjm 4327 34 . . . cord-023095-4dannjjm 4328 1 Group group NN cord-023095-4dannjjm 4328 2 1 1 CD cord-023095-4dannjjm 4328 3 received receive VBD cord-023095-4dannjjm 4328 4 treatment treatment NN cord-023095-4dannjjm 4328 5 with with IN cord-023095-4dannjjm 4328 6 18 18 CD cord-023095-4dannjjm 4328 7 - - SYM cord-023095-4dannjjm 4328 8 20 20 CD cord-023095-4dannjjm 4328 9 mg mg NNP cord-023095-4dannjjm 4328 10 / / SYM cord-023095-4dannjjm 4328 11 kg kg NN cord-023095-4dannjjm 4328 12 oral oral JJ cord-023095-4dannjjm 4328 13 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 4328 14 once once RB cord-023095-4dannjjm 4328 15 daily daily RB cord-023095-4dannjjm 4328 16 for for IN cord-023095-4dannjjm 4328 17 3 3 CD cord-023095-4dannjjm 4328 18 consecutive consecutive JJ cord-023095-4dannjjm 4328 19 days day NNS cord-023095-4dannjjm 4328 20 . . . cord-023095-4dannjjm 4329 1 Group group NN cord-023095-4dannjjm 4329 2 2 2 CD cord-023095-4dannjjm 4329 3 dogs dog NNS cord-023095-4dannjjm 4329 4 were be VBD cord-023095-4dannjjm 4329 5 treated treat VBN cord-023095-4dannjjm 4329 6 with with IN cord-023095-4dannjjm 4329 7 13.75 13.75 CD cord-023095-4dannjjm 4329 8 - - SYM cord-023095-4dannjjm 4329 9 25 25 CD cord-023095-4dannjjm 4329 10 mg mg NNP cord-023095-4dannjjm 4329 11 / / SYM cord-023095-4dannjjm 4329 12 kg kg NNP cord-023095-4dannjjm 4329 13 oral oral JJ cord-023095-4dannjjm 4329 14 amoxicillin amoxicillin NNP cord-023095-4dannjjm 4329 15 - - HYPH cord-023095-4dannjjm 4329 16 clavulante clavulante NNP cord-023095-4dannjjm 4329 17 twice twice RB cord-023095-4dannjjm 4329 18 daily daily RB cord-023095-4dannjjm 4329 19 for for IN cord-023095-4dannjjm 4329 20 14 14 CD cord-023095-4dannjjm 4329 21 days day NNS cord-023095-4dannjjm 4329 22 . . . cord-023095-4dannjjm 4330 1 Both both DT cord-023095-4dannjjm 4330 2 groups group NNS cord-023095-4dannjjm 4330 3 had have VBD cord-023095-4dannjjm 4330 4 urinalyses urinalysis NNS cord-023095-4dannjjm 4330 5 and and CC cord-023095-4dannjjm 4330 6 urine urine NN cord-023095-4dannjjm 4330 7 cultures culture NNS cord-023095-4dannjjm 4330 8 submitted submit VBN cord-023095-4dannjjm 4330 9 on on IN cord-023095-4dannjjm 4330 10 day day NN cord-023095-4dannjjm 4330 11 0 0 CD cord-023095-4dannjjm 4330 12 , , , cord-023095-4dannjjm 4330 13 10 10 CD cord-023095-4dannjjm 4330 14 , , , cord-023095-4dannjjm 4330 15 and and CC cord-023095-4dannjjm 4330 16 21 21 CD cord-023095-4dannjjm 4330 17 . . . cord-023095-4dannjjm 4331 1 At at IN cord-023095-4dannjjm 4331 2 the the DT cord-023095-4dannjjm 4331 3 time time NN cord-023095-4dannjjm 4331 4 of of IN cord-023095-4dannjjm 4331 5 this this DT cord-023095-4dannjjm 4331 6 interim interim JJ cord-023095-4dannjjm 4331 7 analysis analysis NN cord-023095-4dannjjm 4331 8 , , , cord-023095-4dannjjm 4331 9 thirty thirty CD cord-023095-4dannjjm 4331 10 - - HYPH cord-023095-4dannjjm 4331 11 six six CD cord-023095-4dannjjm 4331 12 dogs dog NNS cord-023095-4dannjjm 4331 13 have have VBP cord-023095-4dannjjm 4331 14 completed complete VBN cord-023095-4dannjjm 4331 15 the the DT cord-023095-4dannjjm 4331 16 trial trial NN cord-023095-4dannjjm 4331 17 . . . cord-023095-4dannjjm 4332 1 Bacteriological bacteriological JJ cord-023095-4dannjjm 4332 2 cure cure NN cord-023095-4dannjjm 4332 3 was be VBD cord-023095-4dannjjm 4332 4 achieved achieve VBN cord-023095-4dannjjm 4332 5 in in IN cord-023095-4dannjjm 4332 6 15 15 CD cord-023095-4dannjjm 4332 7 dogs dog NNS cord-023095-4dannjjm 4332 8 ( ( -LRB- cord-023095-4dannjjm 4332 9 83 83 CD cord-023095-4dannjjm 4332 10 % % NN cord-023095-4dannjjm 4332 11 ) ) -RRB- cord-023095-4dannjjm 4332 12 treated treat VBN cord-023095-4dannjjm 4332 13 with with IN cord-023095-4dannjjm 4332 14 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 4332 15 and and CC cord-023095-4dannjjm 4332 16 14 14 CD cord-023095-4dannjjm 4332 17 dogs dog NNS cord-023095-4dannjjm 4332 18 ( ( -LRB- cord-023095-4dannjjm 4332 19 78 78 CD cord-023095-4dannjjm 4332 20 % % NN cord-023095-4dannjjm 4332 21 ) ) -RRB- cord-023095-4dannjjm 4332 22 treated treat VBN cord-023095-4dannjjm 4332 23 with with IN cord-023095-4dannjjm 4332 24 amoxicillinclavulante amoxicillinclavulante NNP cord-023095-4dannjjm 4332 25 , , , cord-023095-4dannjjm 4332 26 respectively respectively RB cord-023095-4dannjjm 4332 27 . . . cord-023095-4dannjjm 4333 1 These these DT cord-023095-4dannjjm 4333 2 data datum NNS cord-023095-4dannjjm 4333 3 suggest suggest VBP cord-023095-4dannjjm 4333 4 that that IN cord-023095-4dannjjm 4333 5 the the DT cord-023095-4dannjjm 4333 6 high high JJ cord-023095-4dannjjm 4333 7 - - HYPH cord-023095-4dannjjm 4333 8 dose dose NN cord-023095-4dannjjm 4333 9 , , , cord-023095-4dannjjm 4333 10 short short JJ cord-023095-4dannjjm 4333 11 - - HYPH cord-023095-4dannjjm 4333 12 duration duration NN cord-023095-4dannjjm 4333 13 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 4333 14 protocol protocol NN cord-023095-4dannjjm 4333 15 was be VBD cord-023095-4dannjjm 4333 16 equally equally RB cord-023095-4dannjjm 4333 17 effective effective JJ cord-023095-4dannjjm 4333 18 to to IN cord-023095-4dannjjm 4333 19 the the DT cord-023095-4dannjjm 4333 20 standard standard JJ cord-023095-4dannjjm 4333 21 protocol protocol NN cord-023095-4dannjjm 4333 22 in in IN cord-023095-4dannjjm 4333 23 treating treat VBG cord-023095-4dannjjm 4333 24 uncomplicated uncomplicated JJ cord-023095-4dannjjm 4333 25 canine canine JJ cord-023095-4dannjjm 4333 26 UTI UTI NNP cord-023095-4dannjjm 4333 27 in in IN cord-023095-4dannjjm 4333 28 the the DT cord-023095-4dannjjm 4333 29 sample sample NN cord-023095-4dannjjm 4333 30 patient patient NN cord-023095-4dannjjm 4333 31 population population NN cord-023095-4dannjjm 4333 32 . . . cord-023095-4dannjjm 4334 1 and and CC cord-023095-4dannjjm 4334 2 may may MD cord-023095-4dannjjm 4334 3 represent represent VB cord-023095-4dannjjm 4334 4 a a DT cord-023095-4dannjjm 4334 5 viable viable JJ cord-023095-4dannjjm 4334 6 alternative alternative JJ cord-023095-4dannjjm 4334 7 therapeutic therapeutic JJ cord-023095-4dannjjm 4334 8 regimen regimen NN cord-023095-4dannjjm 4334 9 for for IN cord-023095-4dannjjm 4334 10 similar similar JJ cord-023095-4dannjjm 4334 11 patients patient NNS cord-023095-4dannjjm 4334 12 . . . cord-023095-4dannjjm 4335 1 Azotemia Azotemia NNP cord-023095-4dannjjm 4335 2 is be VBZ cord-023095-4dannjjm 4335 3 frequent frequent JJ cord-023095-4dannjjm 4335 4 in in IN cord-023095-4dannjjm 4335 5 dogs dog NNS cord-023095-4dannjjm 4335 6 with with IN cord-023095-4dannjjm 4335 7 DMVD DMVD NNP cord-023095-4dannjjm 4336 1 ( ( -LRB- cord-023095-4dannjjm 4336 2 Nicolle Nicolle NNP cord-023095-4dannjjm 4336 3 et et NNP cord-023095-4dannjjm 4336 4 al al NNP cord-023095-4dannjjm 4336 5 ; ; : cord-023095-4dannjjm 4336 6 JVIM JVIM NNP cord-023095-4dannjjm 4336 7 2007 2007 CD cord-023095-4dannjjm 4337 1 ; ; : cord-023095-4dannjjm 4337 2 21:943 21:943 CD cord-023095-4dannjjm 4337 3 - - SYM cord-023095-4dannjjm 4337 4 949 949 CD cord-023095-4dannjjm 4337 5 ) ) -RRB- cord-023095-4dannjjm 4338 1 and and CC cord-023095-4dannjjm 4338 2 could could MD cord-023095-4dannjjm 4338 3 result result VB cord-023095-4dannjjm 4338 4 from from IN cord-023095-4dannjjm 4338 5 renal renal JJ cord-023095-4dannjjm 4338 6 hemodynamic hemodynamic JJ cord-023095-4dannjjm 4338 7 alterations alteration NNS cord-023095-4dannjjm 4338 8 . . . cord-023095-4dannjjm 4339 1 Renal renal JJ cord-023095-4dannjjm 4339 2 resistive resistive JJ cord-023095-4dannjjm 4339 3 index index NN cord-023095-4dannjjm 4339 4 ( ( -LRB- cord-023095-4dannjjm 4339 5 RI RI NNP cord-023095-4dannjjm 4339 6 ) ) -RRB- cord-023095-4dannjjm 4339 7 allows allow VBZ cord-023095-4dannjjm 4339 8 assessment assessment NN cord-023095-4dannjjm 4339 9 of of IN cord-023095-4dannjjm 4339 10 renal renal JJ cord-023095-4dannjjm 4339 11 vascular vascular JJ cord-023095-4dannjjm 4339 12 resistance resistance NN cord-023095-4dannjjm 4339 13 . . . cord-023095-4dannjjm 4340 1 The the DT cord-023095-4dannjjm 4340 2 aim aim NN cord-023095-4dannjjm 4340 3 of of IN cord-023095-4dannjjm 4340 4 this this DT cord-023095-4dannjjm 4340 5 prospective prospective JJ cord-023095-4dannjjm 4340 6 study study NN cord-023095-4dannjjm 4340 7 was be VBD cord-023095-4dannjjm 4340 8 to to TO cord-023095-4dannjjm 4340 9 assess assess VB cord-023095-4dannjjm 4340 10 RI RI NNP cord-023095-4dannjjm 4340 11 in in IN cord-023095-4dannjjm 4340 12 dogs dog NNS cord-023095-4dannjjm 4340 13 with with IN cord-023095-4dannjjm 4340 14 different different JJ cord-023095-4dannjjm 4340 15 DMVD DMVD NNS cord-023095-4dannjjm 4340 16 stages stage NNS cord-023095-4dannjjm 4340 17 . . . cord-023095-4dannjjm 4341 1 Fifty fifty CD cord-023095-4dannjjm 4341 2 - - HYPH cord-023095-4dannjjm 4341 3 five five CD cord-023095-4dannjjm 4341 4 dogs dog NNS cord-023095-4dannjjm 4341 5 with with IN cord-023095-4dannjjm 4341 6 DVMD DVMD NNP cord-023095-4dannjjm 4341 7 were be VBD cord-023095-4dannjjm 4341 8 used use VBN cord-023095-4dannjjm 4341 9 ( ( -LRB- cord-023095-4dannjjm 4341 10 ISACHC ISACHC NNP cord-023095-4dannjjm 4341 11 class class NN cord-023095-4dannjjm 4341 12 1 1 CD cord-023095-4dannjjm 4341 13 ( ( -LRB- cord-023095-4dannjjm 4341 14 n n NN cord-023095-4dannjjm 4341 15 5 5 CD cord-023095-4dannjjm 4341 16 28 28 CD cord-023095-4dannjjm 4341 17 ) ) -RRB- cord-023095-4dannjjm 4341 18 , , , cord-023095-4dannjjm 4341 19 2 2 CD cord-023095-4dannjjm 4341 20 ( ( -LRB- cord-023095-4dannjjm 4341 21 n n NN cord-023095-4dannjjm 4341 22 5 5 CD cord-023095-4dannjjm 4341 23 19 19 CD cord-023095-4dannjjm 4341 24 ) ) -RRB- cord-023095-4dannjjm 4341 25 , , , cord-023095-4dannjjm 4341 26 and and CC cord-023095-4dannjjm 4341 27 3 3 LS cord-023095-4dannjjm 4341 28 ( ( -LRB- cord-023095-4dannjjm 4341 29 n n NN cord-023095-4dannjjm 4341 30 5 5 CD cord-023095-4dannjjm 4341 31 8) 8) NNP cord-023095-4dannjjm 4341 32 ) ) -RRB- cord-023095-4dannjjm 4341 33 . . . cord-023095-4dannjjm 4342 1 Physical physical JJ cord-023095-4dannjjm 4342 2 examination examination NN cord-023095-4dannjjm 4342 3 , , , cord-023095-4dannjjm 4342 4 renal renal JJ cord-023095-4dannjjm 4342 5 ultrasonography ultrasonography NN cord-023095-4dannjjm 4342 6 and and CC cord-023095-4dannjjm 4342 7 echo echo NN cord-023095-4dannjjm 4342 8 - - HYPH cord-023095-4dannjjm 4342 9 Doppler doppler NN cord-023095-4dannjjm 4342 10 examinations examination NNS cord-023095-4dannjjm 4342 11 were be VBD cord-023095-4dannjjm 4342 12 performed perform VBN cord-023095-4dannjjm 4342 13 in in IN cord-023095-4dannjjm 4342 14 awake awake JJ cord-023095-4dannjjm 4342 15 dogs dog NNS cord-023095-4dannjjm 4342 16 by by IN cord-023095-4dannjjm 4342 17 trained train VBN cord-023095-4dannjjm 4342 18 observers observer NNS cord-023095-4dannjjm 4342 19 . . . cord-023095-4dannjjm 4343 1 Plasma plasma NN cord-023095-4dannjjm 4343 2 creatinine creatinine NN cord-023095-4dannjjm 4343 3 , , , cord-023095-4dannjjm 4343 4 urea urea NN cord-023095-4dannjjm 4343 5 and and CC cord-023095-4dannjjm 4343 6 NT NT NNP cord-023095-4dannjjm 4343 7 - - HYPH cord-023095-4dannjjm 4343 8 proBNP proBNP NNP cord-023095-4dannjjm 4343 9 were be VBD cord-023095-4dannjjm 4343 10 measured measure VBN cord-023095-4dannjjm 4343 11 . . . cord-023095-4dannjjm 4344 1 Statistical statistical JJ cord-023095-4dannjjm 4344 2 analyses analysis NNS cord-023095-4dannjjm 4344 3 were be VBD cord-023095-4dannjjm 4344 4 performed perform VBN cord-023095-4dannjjm 4344 5 using use VBG cord-023095-4dannjjm 4344 6 a a DT cord-023095-4dannjjm 4344 7 general general JJ cord-023095-4dannjjm 4344 8 linear linear JJ cord-023095-4dannjjm 4344 9 model model NN cord-023095-4dannjjm 4344 10 . . . cord-023095-4dannjjm 4345 1 Whereas whereas IN cord-023095-4dannjjm 4345 2 RI RI NNP cord-023095-4dannjjm 4345 3 of of IN cord-023095-4dannjjm 4345 4 renal renal JJ cord-023095-4dannjjm 4345 5 and and CC cord-023095-4dannjjm 4345 6 arcuate arcuate JJ cord-023095-4dannjjm 4345 7 arteries artery NNS cord-023095-4dannjjm 4345 8 were be VBD cord-023095-4dannjjm 4345 9 unaffected unaffected JJ cord-023095-4dannjjm 4345 10 by by IN cord-023095-4dannjjm 4345 11 ISACHC ISACHC NNP cord-023095-4dannjjm 4345 12 class class NN cord-023095-4dannjjm 4345 13 , , , cord-023095-4dannjjm 4345 14 left leave VBD cord-023095-4dannjjm 4345 15 interlobar interlobar NN cord-023095-4dannjjm 4345 16 RI RI NNP cord-023095-4dannjjm 4345 17 increased increase VBN cord-023095-4dannjjm 4345 18 ( ( -LRB- cord-023095-4dannjjm 4345 19 P p NN cord-023095-4dannjjm 4345 20 o o NN cord-023095-4dannjjm 4345 21 0.001 0.001 CD cord-023095-4dannjjm 4345 22 ) ) -RRB- cord-023095-4dannjjm 4345 23 from from IN cord-023095-4dannjjm 4345 24 0.62 0.62 CD cord-023095-4dannjjm 4345 25 AE AE NNP cord-023095-4dannjjm 4345 26 0.05 0.05 CD cord-023095-4dannjjm 4345 27 ( ( -LRB- cord-023095-4dannjjm 4345 28 mean mean VB cord-023095-4dannjjm 4345 29 AE AE NNP cord-023095-4dannjjm 4345 30 SD SD NNP cord-023095-4dannjjm 4345 31 ) ) -RRB- cord-023095-4dannjjm 4345 32 in in IN cord-023095-4dannjjm 4345 33 class class NN cord-023095-4dannjjm 4345 34 1 1 CD cord-023095-4dannjjm 4345 35 to to IN cord-023095-4dannjjm 4345 36 0.76 0.76 CD cord-023095-4dannjjm 4345 37 AE AE NNP cord-023095-4dannjjm 4345 38 0.08 0.08 CD cord-023095-4dannjjm 4345 39 in in IN cord-023095-4dannjjm 4345 40 class class NN cord-023095-4dannjjm 4345 41 3 3 CD cord-023095-4dannjjm 4345 42 . . . cord-023095-4dannjjm 4346 1 Left leave VBN cord-023095-4dannjjm 4346 2 interlobar interlobar NN cord-023095-4dannjjm 4346 3 RI RI NNP cord-023095-4dannjjm 4346 4 was be VBD cord-023095-4dannjjm 4346 5 also also RB cord-023095-4dannjjm 4346 6 higher high JJR cord-023095-4dannjjm 4347 1 ( ( -LRB- cord-023095-4dannjjm 4347 2 P p NN cord-023095-4dannjjm 4347 3 o o NN cord-023095-4dannjjm 4347 4 0.001 0.001 CD cord-023095-4dannjjm 4347 5 ) ) -RRB- cord-023095-4dannjjm 4347 6 in in IN cord-023095-4dannjjm 4347 7 azotemic azotemic NNP cord-023095-4dannjjm 4347 8 ( ( -LRB- cord-023095-4dannjjm 4347 9 0.74 0.74 CD cord-023095-4dannjjm 4347 10 AE AE NNP cord-023095-4dannjjm 4347 11 0.008 0.008 CD cord-023095-4dannjjm 4347 12 ) ) -RRB- cord-023095-4dannjjm 4347 13 than than IN cord-023095-4dannjjm 4347 14 in in IN cord-023095-4dannjjm 4347 15 non non JJ cord-023095-4dannjjm 4347 16 azotemic azotemic NNP cord-023095-4dannjjm 4348 1 ( ( -LRB- cord-023095-4dannjjm 4348 2 0.62 0.62 CD cord-023095-4dannjjm 4348 3 AE AE NNP cord-023095-4dannjjm 4348 4 0.005 0.005 CD cord-023095-4dannjjm 4348 5 ) ) -RRB- cord-023095-4dannjjm 4348 6 dogs dog NNS cord-023095-4dannjjm 4348 7 . . . cord-023095-4dannjjm 4349 1 Similar similar JJ cord-023095-4dannjjm 4349 2 findings finding NNS cord-023095-4dannjjm 4349 3 were be VBD cord-023095-4dannjjm 4349 4 observed observe VBN cord-023095-4dannjjm 4349 5 for for IN cord-023095-4dannjjm 4349 6 right right JJ cord-023095-4dannjjm 4349 7 interlobar interlobar NN cord-023095-4dannjjm 4349 8 RI RI NNP cord-023095-4dannjjm 4349 9 . . . cord-023095-4dannjjm 4350 1 A a DT cord-023095-4dannjjm 4350 2 positive positive JJ cord-023095-4dannjjm 4350 3 effect effect NN cord-023095-4dannjjm 4350 4 of of IN cord-023095-4dannjjm 4350 5 NT NT NNP cord-023095-4dannjjm 4350 6 - - HYPH cord-023095-4dannjjm 4350 7 proBNP proBNP NNP cord-023095-4dannjjm 4350 8 ( ( -LRB- cord-023095-4dannjjm 4350 9 P p NN cord-023095-4dannjjm 4350 10 5 5 CD cord-023095-4dannjjm 4350 11 0.002 0.002 CD cord-023095-4dannjjm 4350 12 ) ) -RRB- cord-023095-4dannjjm 4350 13 , , , cord-023095-4dannjjm 4350 14 urea urea NN cord-023095-4dannjjm 4350 15 ( ( -LRB- cord-023095-4dannjjm 4350 16 P p NN cord-023095-4dannjjm 4350 17 o o NN cord-023095-4dannjjm 4350 18 0.001 0.001 CD cord-023095-4dannjjm 4350 19 ) ) -RRB- cord-023095-4dannjjm 4350 20 , , , cord-023095-4dannjjm 4350 21 creatinine creatinine NN cord-023095-4dannjjm 4350 22 ( ( -LRB- cord-023095-4dannjjm 4350 23 P p NN cord-023095-4dannjjm 4350 24 5 5 CD cord-023095-4dannjjm 4350 25 0.002 0.002 CD cord-023095-4dannjjm 4350 26 ) ) -RRB- cord-023095-4dannjjm 4350 27 , , , cord-023095-4dannjjm 4350 28 urea urea NN cord-023095-4dannjjm 4350 29 - - HYPH cord-023095-4dannjjm 4350 30 to to IN cord-023095-4dannjjm 4350 31 - - HYPH cord-023095-4dannjjm 4350 32 creatinine creatinine NN cord-023095-4dannjjm 4350 33 ratio ratio NN cord-023095-4dannjjm 4350 34 ( ( -LRB- cord-023095-4dannjjm 4350 35 P p NN cord-023095-4dannjjm 4350 36 o o NN cord-023095-4dannjjm 4350 37 0.001 0.001 CD cord-023095-4dannjjm 4350 38 ) ) -RRB- cord-023095-4dannjjm 4350 39 , , , cord-023095-4dannjjm 4350 40 left leave VBD cord-023095-4dannjjm 4350 41 atrium atrium NN cord-023095-4dannjjm 4350 42 - - HYPH cord-023095-4dannjjm 4350 43 to to IN cord-023095-4dannjjm 4350 44 - - HYPH cord-023095-4dannjjm 4350 45 aorta aorta NN cord-023095-4dannjjm 4350 46 ratio ratio NN cord-023095-4dannjjm 4350 47 ( ( -LRB- cord-023095-4dannjjm 4350 48 P p NN cord-023095-4dannjjm 4350 49 o o NN cord-023095-4dannjjm 4350 50 0.001 0.001 CD cord-023095-4dannjjm 4350 51 ) ) -RRB- cord-023095-4dannjjm 4350 52 , , , cord-023095-4dannjjm 4350 53 regurgitation regurgitation NN cord-023095-4dannjjm 4350 54 fraction fraction NN cord-023095-4dannjjm 4350 55 ( ( -LRB- cord-023095-4dannjjm 4350 56 P p NN cord-023095-4dannjjm 4350 57 5 5 CD cord-023095-4dannjjm 4350 58 0.011 0.011 CD cord-023095-4dannjjm 4350 59 ) ) -RRB- cord-023095-4dannjjm 4350 60 , , , cord-023095-4dannjjm 4350 61 systolic systolic JJ cord-023095-4dannjjm 4350 62 pulmonary pulmonary JJ cord-023095-4dannjjm 4350 63 arterial arterial JJ cord-023095-4dannjjm 4350 64 pressure pressure NN cord-023095-4dannjjm 4350 65 ( ( -LRB- cord-023095-4dannjjm 4350 66 P p NN cord-023095-4dannjjm 4350 67 o o NN cord-023095-4dannjjm 4350 68 0.001 0.001 CD cord-023095-4dannjjm 4350 69 ) ) -RRB- cord-023095-4dannjjm 4350 70 and and CC cord-023095-4dannjjm 4350 71 shortening shorten VBG cord-023095-4dannjjm 4350 72 fraction fraction NN cord-023095-4dannjjm 4350 73 ( ( -LRB- cord-023095-4dannjjm 4350 74 P p NN cord-023095-4dannjjm 4350 75 5 5 CD cord-023095-4dannjjm 4350 76 0.028 0.028 CD cord-023095-4dannjjm 4350 77 ) ) -RRB- cord-023095-4dannjjm 4350 78 on on IN cord-023095-4dannjjm 4350 79 RI RI NNP cord-023095-4dannjjm 4350 80 was be VBD cord-023095-4dannjjm 4350 81 also also RB cord-023095-4dannjjm 4350 82 observed observe VBN cord-023095-4dannjjm 4350 83 . . . cord-023095-4dannjjm 4351 1 In in IN cord-023095-4dannjjm 4351 2 conclusion conclusion NN cord-023095-4dannjjm 4351 3 , , , cord-023095-4dannjjm 4351 4 interlobar interlobar JJ cord-023095-4dannjjm 4351 5 RI RI NNP cord-023095-4dannjjm 4351 6 increases increase VBZ cord-023095-4dannjjm 4351 7 with with IN cord-023095-4dannjjm 4351 8 the the DT cord-023095-4dannjjm 4351 9 severity severity NN cord-023095-4dannjjm 4351 10 of of IN cord-023095-4dannjjm 4351 11 DMVD DMVD NNP cord-023095-4dannjjm 4351 12 and and CC cord-023095-4dannjjm 4351 13 azotemia azotemia NN cord-023095-4dannjjm 4351 14 . . . cord-023095-4dannjjm 4352 1 A a DT cord-023095-4dannjjm 4352 2 cause cause NN cord-023095-4dannjjm 4352 3 - - HYPH cord-023095-4dannjjm 4352 4 effect effect NN cord-023095-4dannjjm 4352 5 relationship relationship NN cord-023095-4dannjjm 4352 6 remains remain VBZ cord-023095-4dannjjm 4352 7 however however RB cord-023095-4dannjjm 4352 8 to to TO cord-023095-4dannjjm 4352 9 be be VB cord-023095-4dannjjm 4352 10 established establish VBN cord-023095-4dannjjm 4352 11 . . . cord-023095-4dannjjm 4353 1 Antibodies antibody NNS cord-023095-4dannjjm 4353 2 against against IN cord-023095-4dannjjm 4353 3 alpha alpha NN cord-023095-4dannjjm 4353 4 - - HYPH cord-023095-4dannjjm 4353 5 enolase enolase NN cord-023095-4dannjjm 4353 6 are be VBP cord-023095-4dannjjm 4353 7 associated associate VBN cord-023095-4dannjjm 4353 8 with with IN cord-023095-4dannjjm 4353 9 immunemediated immunemediated JJ cord-023095-4dannjjm 4353 10 nephritis nephritis NN cord-023095-4dannjjm 4353 11 in in IN cord-023095-4dannjjm 4353 12 people people NNS cord-023095-4dannjjm 4353 13 . . . cord-023095-4dannjjm 4354 1 It -PRON- PRP cord-023095-4dannjjm 4354 2 was be VBD cord-023095-4dannjjm 4354 3 previously previously RB cord-023095-4dannjjm 4354 4 shown show VBN cord-023095-4dannjjm 4354 5 that that IN cord-023095-4dannjjm 4354 6 vaccinated vaccinate VBN cord-023095-4dannjjm 4354 7 cats cat NNS cord-023095-4dannjjm 4354 8 commonly commonly RB cord-023095-4dannjjm 4354 9 develop develop VBP cord-023095-4dannjjm 4354 10 antibodies antibody NNS cord-023095-4dannjjm 4354 11 against against IN cord-023095-4dannjjm 4354 12 alpha alpha NN cord-023095-4dannjjm 4354 13 - - HYPH cord-023095-4dannjjm 4354 14 enolase enolase NN cord-023095-4dannjjm 4354 15 . . . cord-023095-4dannjjm 4355 1 The the DT cord-023095-4dannjjm 4355 2 purpose purpose NN cord-023095-4dannjjm 4355 3 of of IN cord-023095-4dannjjm 4355 4 this this DT cord-023095-4dannjjm 4355 5 study study NN cord-023095-4dannjjm 4355 6 was be VBD cord-023095-4dannjjm 4355 7 to to TO cord-023095-4dannjjm 4355 8 assess assess VB cord-023095-4dannjjm 4355 9 for for IN cord-023095-4dannjjm 4355 10 associations association NNS cord-023095-4dannjjm 4355 11 between between IN cord-023095-4dannjjm 4355 12 alphaenolase alphaenolase NNP cord-023095-4dannjjm 4355 13 antibodies antibody NNS cord-023095-4dannjjm 4355 14 and and CC cord-023095-4dannjjm 4355 15 azotemia azotemia NN cord-023095-4dannjjm 4355 16 in in IN cord-023095-4dannjjm 4355 17 privately privately RB cord-023095-4dannjjm 4355 18 - - HYPH cord-023095-4dannjjm 4355 19 owned own VBN cord-023095-4dannjjm 4355 20 cats cat NNS cord-023095-4dannjjm 4355 21 . . . cord-023095-4dannjjm 4356 1 Clinically clinically RB cord-023095-4dannjjm 4356 2 stable stable JJ cord-023095-4dannjjm 4356 3 privately privately RB cord-023095-4dannjjm 4356 4 owned own VBN cord-023095-4dannjjm 4356 5 cats cat NNS cord-023095-4dannjjm 4356 6 ! ! . cord-023095-4dannjjm 4357 1 10 10 CD cord-023095-4dannjjm 4357 2 years year NNS cord-023095-4dannjjm 4357 3 of of IN cord-023095-4dannjjm 4357 4 age age NN cord-023095-4dannjjm 4357 5 , , , cord-023095-4dannjjm 4357 6 with with IN cord-023095-4dannjjm 4357 7 and and CC cord-023095-4dannjjm 4357 8 without without IN cord-023095-4dannjjm 4357 9 azotemia azotemia NNP cord-023095-4dannjjm 4357 10 ( ( -LRB- cord-023095-4dannjjm 4357 11 creatinine creatinine NN cord-023095-4dannjjm 4357 12 4 4 CD cord-023095-4dannjjm 4357 13 2 2 CD cord-023095-4dannjjm 4357 14 mg mg NNP cord-023095-4dannjjm 4357 15 / / SYM cord-023095-4dannjjm 4357 16 dl dl NNP cord-023095-4dannjjm 4357 17 ) ) -RRB- cord-023095-4dannjjm 4357 18 , , , cord-023095-4dannjjm 4357 19 and and CC cord-023095-4dannjjm 4357 20 with with IN cord-023095-4dannjjm 4357 21 an an DT cord-023095-4dannjjm 4357 22 available available JJ cord-023095-4dannjjm 4357 23 vaccine vaccine NN cord-023095-4dannjjm 4357 24 history history NN cord-023095-4dannjjm 4357 25 for for IN cord-023095-4dannjjm 4357 26 ! ! . cord-023095-4dannjjm 4358 1 5 5 CD cord-023095-4dannjjm 4358 2 years year NNS cord-023095-4dannjjm 4358 3 were be VBD cord-023095-4dannjjm 4358 4 recruited recruit VBN cord-023095-4dannjjm 4358 5 for for IN cord-023095-4dannjjm 4358 6 the the DT cord-023095-4dannjjm 4358 7 study study NN cord-023095-4dannjjm 4358 8 . . . cord-023095-4dannjjm 4359 1 Sera Sera NNP cord-023095-4dannjjm 4359 2 were be VBD cord-023095-4dannjjm 4359 3 assayed assay VBN cord-023095-4dannjjm 4359 4 for for IN cord-023095-4dannjjm 4359 5 creatinine creatinine NN cord-023095-4dannjjm 4359 6 concentrations concentration NNS cord-023095-4dannjjm 4359 7 and and CC cord-023095-4dannjjm 4359 8 alpha alpha NN cord-023095-4dannjjm 4359 9 - - HYPH cord-023095-4dannjjm 4359 10 enolase enolase JJ cord-023095-4dannjjm 4359 11 antibodies antibody NNS cord-023095-4dannjjm 4359 12 by by IN cord-023095-4dannjjm 4359 13 use use NN cord-023095-4dannjjm 4359 14 of of IN cord-023095-4dannjjm 4359 15 previously previously RB cord-023095-4dannjjm 4359 16 validated validate VBN cord-023095-4dannjjm 4359 17 techniques technique NNS cord-023095-4dannjjm 4359 18 . . . cord-023095-4dannjjm 4360 1 Results result NNS cord-023095-4dannjjm 4360 2 from from IN cord-023095-4dannjjm 4360 3 cats cat NNS cord-023095-4dannjjm 4360 4 with with IN cord-023095-4dannjjm 4360 5 and and CC cord-023095-4dannjjm 4360 6 without without IN cord-023095-4dannjjm 4360 7 azotemia azotemia NN cord-023095-4dannjjm 4360 8 were be VBD cord-023095-4dannjjm 4360 9 compared compare VBN cord-023095-4dannjjm 4360 10 by by IN cord-023095-4dannjjm 4360 11 Student Student NNP cord-023095-4dannjjm 4360 12 's 's POS cord-023095-4dannjjm 4360 13 2-tailed 2-tailed CD cord-023095-4dannjjm 4360 14 t t NN cord-023095-4dannjjm 4360 15 test test NN cord-023095-4dannjjm 4360 16 or or CC cord-023095-4dannjjm 4360 17 Fisher Fisher NNP cord-023095-4dannjjm 4360 18 's 's POS cord-023095-4dannjjm 4360 19 exact exact JJ cord-023095-4dannjjm 4360 20 test test NN cord-023095-4dannjjm 4360 21 with with IN cord-023095-4dannjjm 4360 22 significance significance NN cord-023095-4dannjjm 4360 23 defined define VBN cord-023095-4dannjjm 4360 24 as as IN cord-023095-4dannjjm 4360 25 p p NN cord-023095-4dannjjm 4360 26 o o NN cord-023095-4dannjjm 4360 27 0.05 0.05 CD cord-023095-4dannjjm 4360 28 . . . cord-023095-4dannjjm 4361 1 Median median JJ cord-023095-4dannjjm 4361 2 ages age NNS cord-023095-4dannjjm 4361 3 were be VBD cord-023095-4dannjjm 4361 4 15 15 CD cord-023095-4dannjjm 4361 5 years year NNS cord-023095-4dannjjm 4362 1 ( ( -LRB- cord-023095-4dannjjm 4362 2 range range NN cord-023095-4dannjjm 4362 3 : : : cord-023095-4dannjjm 4362 4 10 10 CD cord-023095-4dannjjm 4362 5 - - SYM cord-023095-4dannjjm 4362 6 18 18 CD cord-023095-4dannjjm 4362 7 ) ) -RRB- cord-023095-4dannjjm 4362 8 and and CC cord-023095-4dannjjm 4362 9 12 12 CD cord-023095-4dannjjm 4362 10 years year NNS cord-023095-4dannjjm 4362 11 ( ( -LRB- cord-023095-4dannjjm 4362 12 range range NN cord-023095-4dannjjm 4362 13 : : : cord-023095-4dannjjm 4362 14 10 10 CD cord-023095-4dannjjm 4362 15 - - SYM cord-023095-4dannjjm 4362 16 15 15 CD cord-023095-4dannjjm 4362 17 ) ) -RRB- cord-023095-4dannjjm 4362 18 for for IN cord-023095-4dannjjm 4362 19 cats cat NNS cord-023095-4dannjjm 4362 20 with with IN cord-023095-4dannjjm 4362 21 ( ( -LRB- cord-023095-4dannjjm 4362 22 n n NN cord-023095-4dannjjm 4362 23 5 5 CD cord-023095-4dannjjm 4362 24 35 35 CD cord-023095-4dannjjm 4362 25 ) ) -RRB- cord-023095-4dannjjm 4362 26 and and CC cord-023095-4dannjjm 4362 27 without without IN cord-023095-4dannjjm 4362 28 azotemia azotemia NNP cord-023095-4dannjjm 4362 29 ( ( -LRB- cord-023095-4dannjjm 4362 30 n n NN cord-023095-4dannjjm 4362 31 5 5 CD cord-023095-4dannjjm 4362 32 27 27 CD cord-023095-4dannjjm 4362 33 ) ) -RRB- cord-023095-4dannjjm 4362 34 , , , cord-023095-4dannjjm 4362 35 respectively respectively RB cord-023095-4dannjjm 4362 36 . . . cord-023095-4dannjjm 4363 1 There there EX cord-023095-4dannjjm 4363 2 was be VBD cord-023095-4dannjjm 4363 3 no no DT cord-023095-4dannjjm 4363 4 significant significant JJ cord-023095-4dannjjm 4363 5 difference difference NN cord-023095-4dannjjm 4363 6 in in IN cord-023095-4dannjjm 4363 7 vaccine vaccine NN cord-023095-4dannjjm 4363 8 events event NNS cord-023095-4dannjjm 4363 9 ( ( -LRB- cord-023095-4dannjjm 4363 10 number number NN cord-023095-4dannjjm 4363 11 , , , cord-023095-4dannjjm 4363 12 type type NN cord-023095-4dannjjm 4363 13 , , , cord-023095-4dannjjm 4363 14 or or CC cord-023095-4dannjjm 4363 15 route route NN cord-023095-4dannjjm 4363 16 of of IN cord-023095-4dannjjm 4363 17 administration administration NN cord-023095-4dannjjm 4363 18 ) ) -RRB- cord-023095-4dannjjm 4363 19 between between IN cord-023095-4dannjjm 4363 20 groups group NNS cord-023095-4dannjjm 4363 21 . . . cord-023095-4dannjjm 4364 1 Azotemic Azotemic NNP cord-023095-4dannjjm 4364 2 cats cat NNS cord-023095-4dannjjm 4364 3 ( ( -LRB- cord-023095-4dannjjm 4364 4 34.3 34.3 CD cord-023095-4dannjjm 4364 5 % % NN cord-023095-4dannjjm 4364 6 ) ) -RRB- cord-023095-4dannjjm 4364 7 were be VBD cord-023095-4dannjjm 4364 8 more more RBR cord-023095-4dannjjm 4364 9 likely likely JJ cord-023095-4dannjjm 4364 10 than than IN cord-023095-4dannjjm 4364 11 normal normal JJ cord-023095-4dannjjm 4364 12 cats cat NNS cord-023095-4dannjjm 4364 13 ( ( -LRB- cord-023095-4dannjjm 4364 14 12.5 12.5 CD cord-023095-4dannjjm 4364 15 % % NN cord-023095-4dannjjm 4364 16 ) ) -RRB- cord-023095-4dannjjm 4364 17 to to TO cord-023095-4dannjjm 4364 18 be be VB cord-023095-4dannjjm 4364 19 positive positive JJ cord-023095-4dannjjm 4364 20 for for IN cord-023095-4dannjjm 4364 21 antibodies antibody NNS cord-023095-4dannjjm 4364 22 against against IN cord-023095-4dannjjm 4364 23 alpha alpha NN cord-023095-4dannjjm 4364 24 - - HYPH cord-023095-4dannjjm 4364 25 enolase enolase NN cord-023095-4dannjjm 4364 26 ( ( -LRB- cord-023095-4dannjjm 4364 27 p p NN cord-023095-4dannjjm 4364 28 5 5 CD cord-023095-4dannjjm 4364 29 0.016 0.016 CD cord-023095-4dannjjm 4364 30 ) ) -RRB- cord-023095-4dannjjm 4364 31 . . . cord-023095-4dannjjm 4365 1 In in IN cord-023095-4dannjjm 4365 2 addition addition NN cord-023095-4dannjjm 4365 3 , , , cord-023095-4dannjjm 4365 4 alpha alpha NN cord-023095-4dannjjm 4365 5 - - HYPH cord-023095-4dannjjm 4365 6 enolase enolase JJ cord-023095-4dannjjm 4365 7 antibody antibody NN cord-023095-4dannjjm 4365 8 concentrations concentration NNS cord-023095-4dannjjm 4365 9 were be VBD cord-023095-4dannjjm 4365 10 greater great JJR cord-023095-4dannjjm 4365 11 ( ( -LRB- cord-023095-4dannjjm 4365 12 p p NN cord-023095-4dannjjm 4365 13 5 5 CD cord-023095-4dannjjm 4365 14 0.041 0.041 CD cord-023095-4dannjjm 4365 15 ) ) -RRB- cord-023095-4dannjjm 4365 16 in in IN cord-023095-4dannjjm 4365 17 azotemic azotemic JJ cord-023095-4dannjjm 4365 18 cats cat NNS cord-023095-4dannjjm 4365 19 ( ( -LRB- cord-023095-4dannjjm 4365 20 mean mean VBP cord-023095-4dannjjm 4365 21 % % NN cord-023095-4dannjjm 4365 22 ELISA ELISA NNP cord-023095-4dannjjm 4365 23 5 5 CD cord-023095-4dannjjm 4365 24 62.5 62.5 CD cord-023095-4dannjjm 4365 25 % % NN cord-023095-4dannjjm 4365 26 ) ) -RRB- cord-023095-4dannjjm 4365 27 than than IN cord-023095-4dannjjm 4365 28 cats cat NNS cord-023095-4dannjjm 4365 29 with with IN cord-023095-4dannjjm 4365 30 normal normal JJ cord-023095-4dannjjm 4365 31 creatinine creatinine NN cord-023095-4dannjjm 4365 32 concentrations concentration NNS cord-023095-4dannjjm 4366 1 ( ( -LRB- cord-023095-4dannjjm 4366 2 mean mean VB cord-023095-4dannjjm 4366 3 % % NN cord-023095-4dannjjm 4366 4 ELISA ELISA NNP cord-023095-4dannjjm 4366 5 5 5 CD cord-023095-4dannjjm 4366 6 47.2 47.2 CD cord-023095-4dannjjm 4366 7 % % NN cord-023095-4dannjjm 4366 8 ) ) -RRB- cord-023095-4dannjjm 4366 9 . . . cord-023095-4dannjjm 4367 1 Results result NNS cord-023095-4dannjjm 4367 2 of of IN cord-023095-4dannjjm 4367 3 this this DT cord-023095-4dannjjm 4367 4 study study NN cord-023095-4dannjjm 4367 5 suggest suggest VBP cord-023095-4dannjjm 4367 6 that that IN cord-023095-4dannjjm 4367 7 antibodies antibody NNS cord-023095-4dannjjm 4367 8 against against IN cord-023095-4dannjjm 4367 9 alpha alpha NN cord-023095-4dannjjm 4367 10 - - NN cord-023095-4dannjjm 4367 11 enolase enolase NN cord-023095-4dannjjm 4367 12 in in IN cord-023095-4dannjjm 4367 13 cats cat NNS cord-023095-4dannjjm 4367 14 may may MD cord-023095-4dannjjm 4367 15 be be VB cord-023095-4dannjjm 4367 16 associated associate VBN cord-023095-4dannjjm 4367 17 with with IN cord-023095-4dannjjm 4367 18 renal renal JJ cord-023095-4dannjjm 4367 19 disease disease NN cord-023095-4dannjjm 4367 20 . . . cord-023095-4dannjjm 4368 1 Additional additional JJ cord-023095-4dannjjm 4368 2 prospective prospective JJ cord-023095-4dannjjm 4368 3 evaluation evaluation NN cord-023095-4dannjjm 4368 4 in in IN cord-023095-4dannjjm 4368 5 a a DT cord-023095-4dannjjm 4368 6 larger large JJR cord-023095-4dannjjm 4368 7 number number NN cord-023095-4dannjjm 4368 8 of of IN cord-023095-4dannjjm 4368 9 cats cat NNS cord-023095-4dannjjm 4368 10 is be VBZ cord-023095-4dannjjm 4368 11 indicated indicate VBN cord-023095-4dannjjm 4368 12 . . . cord-023095-4dannjjm 4369 1 AKI AKI NNP cord-023095-4dannjjm 4369 2 is be VBZ cord-023095-4dannjjm 4369 3 used use VBN cord-023095-4dannjjm 4369 4 in in IN cord-023095-4dannjjm 4369 5 human human JJ cord-023095-4dannjjm 4369 6 medicine medicine NN cord-023095-4dannjjm 4369 7 as as IN cord-023095-4dannjjm 4369 8 a a DT cord-023095-4dannjjm 4369 9 predictor predictor NN cord-023095-4dannjjm 4369 10 of of IN cord-023095-4dannjjm 4369 11 mortality mortality NN cord-023095-4dannjjm 4369 12 based base VBN cord-023095-4dannjjm 4369 13 on on IN cord-023095-4dannjjm 4369 14 the the DT cord-023095-4dannjjm 4369 15 AKIN akin NN cord-023095-4dannjjm 4369 16 ( ( -LRB- cord-023095-4dannjjm 4369 17 Acute acute JJ cord-023095-4dannjjm 4369 18 Kidney Kidney NNP cord-023095-4dannjjm 4369 19 Injury Injury NNP cord-023095-4dannjjm 4369 20 Network Network NNP cord-023095-4dannjjm 4369 21 ) ) -RRB- cord-023095-4dannjjm 4369 22 scoring score VBG cord-023095-4dannjjm 4369 23 system system NN cord-023095-4dannjjm 4369 24 which which WDT cord-023095-4dannjjm 4369 25 utilizes utilize VBZ cord-023095-4dannjjm 4369 26 relative relative JJ cord-023095-4dannjjm 4369 27 increases increase NNS cord-023095-4dannjjm 4369 28 in in IN cord-023095-4dannjjm 4369 29 creatinine creatinine NN cord-023095-4dannjjm 4369 30 to to TO cord-023095-4dannjjm 4369 31 determine determine VB cord-023095-4dannjjm 4369 32 stage stage NN cord-023095-4dannjjm 4369 33 . . . cord-023095-4dannjjm 4370 1 With with IN cord-023095-4dannjjm 4370 2 this this DT cord-023095-4dannjjm 4370 3 scheme scheme NN cord-023095-4dannjjm 4370 4 , , , cord-023095-4dannjjm 4370 5 mortality mortality NN cord-023095-4dannjjm 4370 6 has have VBZ cord-023095-4dannjjm 4370 7 been be VBN cord-023095-4dannjjm 4370 8 shown show VBN cord-023095-4dannjjm 4370 9 to to TO cord-023095-4dannjjm 4370 10 increase increase VB cord-023095-4dannjjm 4370 11 as as IN cord-023095-4dannjjm 4370 12 the the DT cord-023095-4dannjjm 4370 13 stage stage NN cord-023095-4dannjjm 4370 14 of of IN cord-023095-4dannjjm 4370 15 kidney kidney NN cord-023095-4dannjjm 4370 16 injury injury NN cord-023095-4dannjjm 4370 17 ( ( -LRB- cord-023095-4dannjjm 4370 18 indicated indicate VBN cord-023095-4dannjjm 4370 19 by by IN cord-023095-4dannjjm 4370 20 AKIN AKIN NNP cord-023095-4dannjjm 4370 21 score score NN cord-023095-4dannjjm 4370 22 ) ) -RRB- cord-023095-4dannjjm 4370 23 increases increase NNS cord-023095-4dannjjm 4370 24 . . . cord-023095-4dannjjm 4371 1 Accordingly accordingly RB cord-023095-4dannjjm 4371 2 , , , cord-023095-4dannjjm 4371 3 we -PRON- PRP cord-023095-4dannjjm 4371 4 hypothesized hypothesize VBD cord-023095-4dannjjm 4371 5 that that IN cord-023095-4dannjjm 4371 6 this this DT cord-023095-4dannjjm 4371 7 system system NN cord-023095-4dannjjm 4371 8 would would MD cord-023095-4dannjjm 4371 9 improve improve VB cord-023095-4dannjjm 4371 10 predicting predict VBG cord-023095-4dannjjm 4371 11 prognosis prognosis NN cord-023095-4dannjjm 4371 12 in in IN cord-023095-4dannjjm 4371 13 dogs dog NNS cord-023095-4dannjjm 4371 14 and and CC cord-023095-4dannjjm 4371 15 cats cat NNS cord-023095-4dannjjm 4371 16 . . . cord-023095-4dannjjm 4372 1 We -PRON- PRP cord-023095-4dannjjm 4372 2 retrospectively retrospectively RB cord-023095-4dannjjm 4372 3 evaluated evaluate VBD cord-023095-4dannjjm 4372 4 1088 1088 CD cord-023095-4dannjjm 4372 5 dogs dog NNS cord-023095-4dannjjm 4372 6 and and CC cord-023095-4dannjjm 4372 7 856 856 CD cord-023095-4dannjjm 4372 8 cats cat NNS cord-023095-4dannjjm 4372 9 ( ( -LRB- cord-023095-4dannjjm 4372 10 2008 2008 CD cord-023095-4dannjjm 4372 11 ) ) -RRB- cord-023095-4dannjjm 4372 12 ( ( -LRB- cord-023095-4dannjjm 4372 13 2009 2009 CD cord-023095-4dannjjm 4372 14 ) ) -RRB- cord-023095-4dannjjm 4372 15 ) ) -RRB- cord-023095-4dannjjm 4372 16 that that WDT cord-023095-4dannjjm 4372 17 had have VBD cord-023095-4dannjjm 4372 18 ! ! . cord-023095-4dannjjm 4373 1 2 2 CD cord-023095-4dannjjm 4373 2 creatinine creatinine NN cord-023095-4dannjjm 4373 3 measurements measurement NNS cord-023095-4dannjjm 4373 4 within within IN cord-023095-4dannjjm 4373 5 7 7 CD cord-023095-4dannjjm 4373 6 days day NNS cord-023095-4dannjjm 4373 7 , , , cord-023095-4dannjjm 4373 8 and and CC cord-023095-4dannjjm 4374 1 whose whose WP$ cord-023095-4dannjjm 4374 2 first first JJ cord-023095-4dannjjm 4374 3 creatinine creatinine NN cord-023095-4dannjjm 4374 4 was be VBD cord-023095-4dannjjm 4374 5 o o UH cord-023095-4dannjjm 4375 1 1.6 1.6 CD cord-023095-4dannjjm 4375 2 mg mg NNP cord-023095-4dannjjm 4375 3 / / SYM cord-023095-4dannjjm 4375 4 dl dl NN cord-023095-4dannjjm 4375 5 . . . cord-023095-4dannjjm 4376 1 Patients patient NNS cord-023095-4dannjjm 4376 2 were be VBD cord-023095-4dannjjm 4376 3 categorized categorize VBN cord-023095-4dannjjm 4376 4 as as IN cord-023095-4dannjjm 4376 5 : : : cord-023095-4dannjjm 4376 6 Level level NN cord-023095-4dannjjm 4376 7 0 0 NFP cord-023095-4dannjjm 4376 8 ( ( -LRB- cord-023095-4dannjjm 4376 9 no no DT cord-023095-4dannjjm 4376 10 AKI AKI NNP cord-023095-4dannjjm 4376 11 ) ) -RRB- cord-023095-4dannjjm 4376 12 ; ; : cord-023095-4dannjjm 4376 13 Level level NN cord-023095-4dannjjm 4376 14 1 1 CD cord-023095-4dannjjm 4376 15 ( ( -LRB- cord-023095-4dannjjm 4376 16 second second JJ cord-023095-4dannjjm 4376 17 creatinine creatinine NN cord-023095-4dannjjm 4376 18 value value NN cord-023095-4dannjjm 4376 19 o o NN cord-023095-4dannjjm 4376 20 1.6 1.6 CD cord-023095-4dannjjm 4376 21 mg mg NNP cord-023095-4dannjjm 4376 22 / / SYM cord-023095-4dannjjm 4376 23 dL dl NN cord-023095-4dannjjm 4376 24 , , , cord-023095-4dannjjm 4376 25 but but CC cord-023095-4dannjjm 4376 26 creatinine creatinine NN cord-023095-4dannjjm 4376 27 increased increase VBD cord-023095-4dannjjm 4376 28 ! ! . cord-023095-4dannjjm 4377 1 0.3 0.3 CD cord-023095-4dannjjm 4377 2 mg mg NNP cord-023095-4dannjjm 4377 3 / / SYM cord-023095-4dannjjm 4377 4 dL dl NN cord-023095-4dannjjm 4377 5 ) ) -RRB- cord-023095-4dannjjm 4377 6 ; ; : cord-023095-4dannjjm 4377 7 or or CC cord-023095-4dannjjm 4377 8 Level Level NNP cord-023095-4dannjjm 4377 9 3 3 CD cord-023095-4dannjjm 4377 10 ( ( -LRB- cord-023095-4dannjjm 4377 11 second second JJ cord-023095-4dannjjm 4377 12 creatinine creatinine NN cord-023095-4dannjjm 4378 1 4 4 LS cord-023095-4dannjjm 4378 2 1.6 1.6 CD cord-023095-4dannjjm 4378 3 mg mg NNP cord-023095-4dannjjm 4378 4 / / SYM cord-023095-4dannjjm 4378 5 dL dl NN cord-023095-4dannjjm 4378 6 with with IN cord-023095-4dannjjm 4378 7 a a DT cord-023095-4dannjjm 4378 8 creatinine creatinine NN cord-023095-4dannjjm 4378 9 increase increase NN cord-023095-4dannjjm 4378 10 ! ! . cord-023095-4dannjjm 4379 1 0.3 0.3 CD cord-023095-4dannjjm 4379 2 mg mg NNP cord-023095-4dannjjm 4379 3 / / SYM cord-023095-4dannjjm 4379 4 dL dl NN cord-023095-4dannjjm 4379 5 ) ) -RRB- cord-023095-4dannjjm 4379 6 . . . cord-023095-4dannjjm 4380 1 Thirty thirty CD cord-023095-4dannjjm 4380 2 and and CC cord-023095-4dannjjm 4380 3 90 90 CD cord-023095-4dannjjm 4380 4 day day NN cord-023095-4dannjjm 4380 5 survival survival NN cord-023095-4dannjjm 4380 6 for for IN cord-023095-4dannjjm 4380 7 each each DT cord-023095-4dannjjm 4380 8 level level NN cord-023095-4dannjjm 4380 9 was be VBD cord-023095-4dannjjm 4380 10 compared compare VBN cord-023095-4dannjjm 4380 11 to to IN cord-023095-4dannjjm 4380 12 level level NN cord-023095-4dannjjm 4380 13 0 0 CD cord-023095-4dannjjm 4380 14 . . . cord-023095-4dannjjm 4381 1 Adjusted adjusted JJ cord-023095-4dannjjm 4381 2 odds odd NNS cord-023095-4dannjjm 4381 3 ratio ratio NN cord-023095-4dannjjm 4381 4 ( ( -LRB- cord-023095-4dannjjm 4381 5 OR or NN cord-023095-4dannjjm 4381 6 ) ) -RRB- cord-023095-4dannjjm 4382 1 in in IN cord-023095-4dannjjm 4382 2 dogs dog NNS cord-023095-4dannjjm 4382 3 for for IN cord-023095-4dannjjm 4382 4 30 30 CD cord-023095-4dannjjm 4382 5 day day NN cord-023095-4dannjjm 4382 6 survival survival NN cord-023095-4dannjjm 4382 7 was be VBD cord-023095-4dannjjm 4382 8 1.3 1.3 CD cord-023095-4dannjjm 4382 9 for for IN cord-023095-4dannjjm 4382 10 Level level NN cord-023095-4dannjjm 4382 11 1 1 CD cord-023095-4dannjjm 4382 12 ( ( -LRB- cord-023095-4dannjjm 4382 13 CI CI NNP cord-023095-4dannjjm 4382 14 95 95 CD cord-023095-4dannjjm 4382 15 % % NN cord-023095-4dannjjm 4382 16 , , , cord-023095-4dannjjm 4382 17 0.8 0.8 CD cord-023095-4dannjjm 4382 18 - - SYM cord-023095-4dannjjm 4382 19 2.2 2.2 CD cord-023095-4dannjjm 4382 20 ) ) -RRB- cord-023095-4dannjjm 4382 21 and and CC cord-023095-4dannjjm 4382 22 3.2 3.2 CD cord-023095-4dannjjm 4383 1 ( ( -LRB- cord-023095-4dannjjm 4383 2 CI CI NNP cord-023095-4dannjjm 4383 3 95 95 CD cord-023095-4dannjjm 4383 4 % % NN cord-023095-4dannjjm 4383 5 , , , cord-023095-4dannjjm 4383 6 1.8 1.8 CD cord-023095-4dannjjm 4383 7 - - SYM cord-023095-4dannjjm 4383 8 5.5 5.5 CD cord-023095-4dannjjm 4383 9 ) ) -RRB- cord-023095-4dannjjm 4383 10 for for IN cord-023095-4dannjjm 4383 11 Level level NN cord-023095-4dannjjm 4383 12 2 2 CD cord-023095-4dannjjm 4383 13 ; ; : cord-023095-4dannjjm 4383 14 OR or CC cord-023095-4dannjjm 4383 15 for for IN cord-023095-4dannjjm 4383 16 90 90 CD cord-023095-4dannjjm 4383 17 day day NN cord-023095-4dannjjm 4383 18 survival survival NN cord-023095-4dannjjm 4383 19 was be VBD cord-023095-4dannjjm 4383 20 1.3 1.3 CD cord-023095-4dannjjm 4383 21 for for IN cord-023095-4dannjjm 4383 22 Level level NN cord-023095-4dannjjm 4383 23 1 1 CD cord-023095-4dannjjm 4383 24 ( ( -LRB- cord-023095-4dannjjm 4383 25 CI CI NNP cord-023095-4dannjjm 4383 26 95 95 CD cord-023095-4dannjjm 4383 27 % % NN cord-023095-4dannjjm 4383 28 , , , cord-023095-4dannjjm 4383 29 0.8 0.8 CD cord-023095-4dannjjm 4383 30 - - SYM cord-023095-4dannjjm 4383 31 2.2 2.2 CD cord-023095-4dannjjm 4383 32 ) ) -RRB- cord-023095-4dannjjm 4383 33 and and CC cord-023095-4dannjjm 4383 34 3.7 3.7 CD cord-023095-4dannjjm 4383 35 ( ( -LRB- cord-023095-4dannjjm 4383 36 CI CI NNP cord-023095-4dannjjm 4383 37 95 95 CD cord-023095-4dannjjm 4383 38 % % NN cord-023095-4dannjjm 4383 39 , , , cord-023095-4dannjjm 4383 40 2.1 2.1 CD cord-023095-4dannjjm 4383 41 - - SYM cord-023095-4dannjjm 4383 42 6.5 6.5 CD cord-023095-4dannjjm 4383 43 ) ) -RRB- cord-023095-4dannjjm 4383 44 for for IN cord-023095-4dannjjm 4383 45 Level level NN cord-023095-4dannjjm 4383 46 2 2 CD cord-023095-4dannjjm 4383 47 . . . cord-023095-4dannjjm 4384 1 For for IN cord-023095-4dannjjm 4384 2 cats cat NNS cord-023095-4dannjjm 4384 3 , , , cord-023095-4dannjjm 4384 4 OR or CC cord-023095-4dannjjm 4384 5 at at IN cord-023095-4dannjjm 4384 6 30 30 CD cord-023095-4dannjjm 4384 7 days day NNS cord-023095-4dannjjm 4384 8 was be VBD cord-023095-4dannjjm 4384 9 1.5 1.5 CD cord-023095-4dannjjm 4384 10 ( ( -LRB- cord-023095-4dannjjm 4384 11 CI CI NNP cord-023095-4dannjjm 4384 12 95 95 CD cord-023095-4dannjjm 4384 13 % % NN cord-023095-4dannjjm 4384 14 , , , cord-023095-4dannjjm 4384 15 0.5 0.5 CD cord-023095-4dannjjm 4384 16 - - SYM cord-023095-4dannjjm 4384 17 4.6 4.6 CD cord-023095-4dannjjm 4384 18 ) ) -RRB- cord-023095-4dannjjm 4384 19 for for IN cord-023095-4dannjjm 4384 20 Level level NN cord-023095-4dannjjm 4384 21 1 1 CD cord-023095-4dannjjm 4384 22 and and CC cord-023095-4dannjjm 4384 23 3.1 3.1 CD cord-023095-4dannjjm 4384 24 ( ( -LRB- cord-023095-4dannjjm 4384 25 CI CI NNP cord-023095-4dannjjm 4384 26 95 95 CD cord-023095-4dannjjm 4384 27 % % NN cord-023095-4dannjjm 4384 28 , , , cord-023095-4dannjjm 4384 29 1.5 1.5 CD cord-023095-4dannjjm 4384 30 - - SYM cord-023095-4dannjjm 4384 31 6.7 6.7 CD cord-023095-4dannjjm 4384 32 ) ) -RRB- cord-023095-4dannjjm 4384 33 for for IN cord-023095-4dannjjm 4384 34 Level level NN cord-023095-4dannjjm 4384 35 2 2 CD cord-023095-4dannjjm 4384 36 ; ; : cord-023095-4dannjjm 4384 37 OR or CC cord-023095-4dannjjm 4384 38 for for IN cord-023095-4dannjjm 4384 39 90 90 CD cord-023095-4dannjjm 4384 40 day day NN cord-023095-4dannjjm 4384 41 survival survival NN cord-023095-4dannjjm 4384 42 was be VBD cord-023095-4dannjjm 4384 43 0.9 0.9 CD cord-023095-4dannjjm 4385 1 ( ( -LRB- cord-023095-4dannjjm 4385 2 CI CI NNP cord-023095-4dannjjm 4385 3 95 95 CD cord-023095-4dannjjm 4385 4 % % NN cord-023095-4dannjjm 4385 5 , , , cord-023095-4dannjjm 4385 6 0.3 0.3 CD cord-023095-4dannjjm 4385 7 - - SYM cord-023095-4dannjjm 4385 8 2.8 2.8 CD cord-023095-4dannjjm 4385 9 ) ) -RRB- cord-023095-4dannjjm 4385 10 for for IN cord-023095-4dannjjm 4385 11 Level level NN cord-023095-4dannjjm 4385 12 1 1 CD cord-023095-4dannjjm 4385 13 and and CC cord-023095-4dannjjm 4385 14 4.1 4.1 CD cord-023095-4dannjjm 4386 1 ( ( -LRB- cord-023095-4dannjjm 4386 2 CI CI NNP cord-023095-4dannjjm 4386 3 95 95 CD cord-023095-4dannjjm 4386 4 % % NN cord-023095-4dannjjm 4386 5 , , , cord-023095-4dannjjm 4386 6 1.8 1.8 CD cord-023095-4dannjjm 4386 7 - - SYM cord-023095-4dannjjm 4386 8 9.3 9.3 CD cord-023095-4dannjjm 4386 9 ) ) -RRB- cord-023095-4dannjjm 4386 10 for for IN cord-023095-4dannjjm 4386 11 Level level NN cord-023095-4dannjjm 4386 12 2 2 CD cord-023095-4dannjjm 4386 13 . . . cord-023095-4dannjjm 4387 1 Thus thus RB cord-023095-4dannjjm 4387 2 , , , cord-023095-4dannjjm 4387 3 detecting detect VBG cord-023095-4dannjjm 4387 4 increasing increase VBG cord-023095-4dannjjm 4387 5 stage stage NN cord-023095-4dannjjm 4387 6 of of IN cord-023095-4dannjjm 4387 7 AKI AKI NNP cord-023095-4dannjjm 4387 8 helps help VBZ cord-023095-4dannjjm 4387 9 predict predict VB cord-023095-4dannjjm 4387 10 mortality mortality NN cord-023095-4dannjjm 4387 11 in in IN cord-023095-4dannjjm 4387 12 dogs dog NNS cord-023095-4dannjjm 4387 13 and and CC cord-023095-4dannjjm 4387 14 cats cat NNS cord-023095-4dannjjm 4387 15 . . . cord-023095-4dannjjm 4388 1 ABSTRACT ABSTRACT NNP cord-023095-4dannjjm 4388 2 N N NNP cord-023095-4dannjjm 4388 3 / / SYM cord-023095-4dannjjm 4388 4 U-27 U-27 NNP cord-023095-4dannjjm 4388 5 FELINE feline JJ cord-023095-4dannjjm 4388 6 URATE URATE NNP cord-023095-4dannjjm 4388 7 UROLITHIASIS UROLITHIASIS NNP cord-023095-4dannjjm 4388 8 : : : cord-023095-4dannjjm 4388 9 143 143 CD cord-023095-4dannjjm 4388 10 CASES case NNS cord-023095-4dannjjm 4388 11 ( ( -LRB- cord-023095-4dannjjm 4388 12 2000 2000 CD cord-023095-4dannjjm 4388 13 -2008 -2008 NN cord-023095-4dannjjm 4388 14 . . . cord-023095-4dannjjm 4389 1 J J NNP cord-023095-4dannjjm 4389 2 Dear Dear NNP cord-023095-4dannjjm 4389 3 1 1 CD cord-023095-4dannjjm 4389 4 , , , cord-023095-4dannjjm 4389 5 R R NNP cord-023095-4dannjjm 4389 6 Shiraki Shiraki NNP cord-023095-4dannjjm 4389 7 2 2 CD cord-023095-4dannjjm 4389 8 , , , cord-023095-4dannjjm 4389 9 A a DT cord-023095-4dannjjm 4389 10 Ruby Ruby NNP cord-023095-4dannjjm 4389 11 2 2 CD cord-023095-4dannjjm 4389 12 , , , cord-023095-4dannjjm 4389 13 J J NNP cord-023095-4dannjjm 4389 14 Westropp Westropp NNP cord-023095-4dannjjm 4389 15 3 3 CD cord-023095-4dannjjm 4389 16 . . . cord-023095-4dannjjm 4390 1 1 1 LS cord-023095-4dannjjm 4391 1 William William NNP cord-023095-4dannjjm 4391 2 R R NNP cord-023095-4dannjjm 4391 3 Pritchard Pritchard NNP cord-023095-4dannjjm 4391 4 Veterinary Veterinary NNP cord-023095-4dannjjm 4391 5 Medical Medical NNP cord-023095-4dannjjm 4391 6 Teaching Teaching NNP cord-023095-4dannjjm 4391 7 Hospital Hospital NNP cord-023095-4dannjjm 4391 8 , , , cord-023095-4dannjjm 4391 9 University University NNP cord-023095-4dannjjm 4391 10 of of IN cord-023095-4dannjjm 4391 11 California California NNP cord-023095-4dannjjm 4391 12 , , , cord-023095-4dannjjm 4391 13 Davis Davis NNP cord-023095-4dannjjm 4391 14 , , , cord-023095-4dannjjm 4391 15 CA CA NNP cord-023095-4dannjjm 4391 16 , , , cord-023095-4dannjjm 4391 17 2 2 CD cord-023095-4dannjjm 4391 18 Gerald Gerald NNP cord-023095-4dannjjm 4391 19 V. V. NNP cord-023095-4dannjjm 4391 20 Ling Ling NNP cord-023095-4dannjjm 4391 21 Urinary Urinary NNP cord-023095-4dannjjm 4391 22 Stone Stone NNP cord-023095-4dannjjm 4391 23 Analysis Analysis NNP cord-023095-4dannjjm 4391 24 Laboratory Laboratory NNP cord-023095-4dannjjm 4391 25 , , , cord-023095-4dannjjm 4391 26 University University NNP cord-023095-4dannjjm 4391 27 of of IN cord-023095-4dannjjm 4391 28 California California NNP cord-023095-4dannjjm 4391 29 , , , cord-023095-4dannjjm 4391 30 Davis Davis NNP cord-023095-4dannjjm 4391 31 , , , cord-023095-4dannjjm 4391 32 CA CA NNP cord-023095-4dannjjm 4391 33 and and CC cord-023095-4dannjjm 4391 34 3 3 CD cord-023095-4dannjjm 4391 35 the the DT cord-023095-4dannjjm 4391 36 Department Department NNP cord-023095-4dannjjm 4391 37 of of IN cord-023095-4dannjjm 4391 38 Veterinary Veterinary NNP cord-023095-4dannjjm 4391 39 Medicine Medicine NNP cord-023095-4dannjjm 4391 40 and and CC cord-023095-4dannjjm 4391 41 Epidemiology Epidemiology NNP cord-023095-4dannjjm 4391 42 , , , cord-023095-4dannjjm 4391 43 University University NNP cord-023095-4dannjjm 4391 44 of of IN cord-023095-4dannjjm 4391 45 California California NNP cord-023095-4dannjjm 4391 46 , , , cord-023095-4dannjjm 4391 47 Davis Davis NNP cord-023095-4dannjjm 4391 48 , , , cord-023095-4dannjjm 4391 49 CA CA NNP cord-023095-4dannjjm 4391 50 . . . cord-023095-4dannjjm 4392 1 Feline feline JJ cord-023095-4dannjjm 4392 2 urate urate NN cord-023095-4dannjjm 4392 3 urolithiasis urolithiasis NN cord-023095-4dannjjm 4392 4 accounts account VBZ cord-023095-4dannjjm 4392 5 for for IN cord-023095-4dannjjm 4392 6 10 10 CD cord-023095-4dannjjm 4392 7 % % NN cord-023095-4dannjjm 4392 8 of of IN cord-023095-4dannjjm 4392 9 the the DT cord-023095-4dannjjm 4392 10 feline feline JJ cord-023095-4dannjjm 4392 11 stones stone NNS cord-023095-4dannjjm 4392 12 our -PRON- PRP$ cord-023095-4dannjjm 4392 13 laboratory laboratory NN cord-023095-4dannjjm 4392 14 analyzes analyze VBZ cord-023095-4dannjjm 4392 15 each each DT cord-023095-4dannjjm 4392 16 year year NN cord-023095-4dannjjm 4392 17 ; ; : cord-023095-4dannjjm 4392 18 little little JJ cord-023095-4dannjjm 4392 19 information information NN cord-023095-4dannjjm 4392 20 is be VBZ cord-023095-4dannjjm 4392 21 known know VBN cord-023095-4dannjjm 4392 22 about about IN cord-023095-4dannjjm 4392 23 this this DT cord-023095-4dannjjm 4392 24 disease disease NN cord-023095-4dannjjm 4392 25 , , , cord-023095-4dannjjm 4392 26 particularly particularly RB cord-023095-4dannjjm 4392 27 the the DT cord-023095-4dannjjm 4392 28 incidence incidence NN cord-023095-4dannjjm 4392 29 of of IN cord-023095-4dannjjm 4392 30 those those DT cord-023095-4dannjjm 4392 31 cats cat NNS cord-023095-4dannjjm 4392 32 with with IN cord-023095-4dannjjm 4392 33 hepatopathies hepatopathie NNS cord-023095-4dannjjm 4392 34 . . . cord-023095-4dannjjm 4393 1 The the DT cord-023095-4dannjjm 4393 2 objective objective NN cord-023095-4dannjjm 4393 3 of of IN cord-023095-4dannjjm 4393 4 the the DT cord-023095-4dannjjm 4393 5 study study NN cord-023095-4dannjjm 4393 6 was be VBD cord-023095-4dannjjm 4393 7 to to TO cord-023095-4dannjjm 4393 8 characterize characterize VB cord-023095-4dannjjm 4393 9 the the DT cord-023095-4dannjjm 4393 10 signalment signalment JJ cord-023095-4dannjjm 4393 11 , , , cord-023095-4dannjjm 4393 12 clinicopathologic clinicopathologic NNP cord-023095-4dannjjm 4393 13 data datum NNS cord-023095-4dannjjm 4393 14 , , , cord-023095-4dannjjm 4393 15 and and CC cord-023095-4dannjjm 4393 16 diagnostic diagnostic JJ cord-023095-4dannjjm 4393 17 imaging imaging NN cord-023095-4dannjjm 4393 18 of of IN cord-023095-4dannjjm 4393 19 cats cat NNS cord-023095-4dannjjm 4393 20 with with IN cord-023095-4dannjjm 4393 21 this this DT cord-023095-4dannjjm 4393 22 disease disease NN cord-023095-4dannjjm 4393 23 as as RB cord-023095-4dannjjm 4393 24 well well RB cord-023095-4dannjjm 4393 25 as as IN cord-023095-4dannjjm 4393 26 the the DT cord-023095-4dannjjm 4393 27 salts salt NNS cord-023095-4dannjjm 4393 28 of of IN cord-023095-4dannjjm 4393 29 uric uric NN cord-023095-4dannjjm 4393 30 acid acid NN cord-023095-4dannjjm 4393 31 present present JJ cord-023095-4dannjjm 4393 32 . . . cord-023095-4dannjjm 4394 1 A a DT cord-023095-4dannjjm 4394 2 retrospective retrospective JJ cord-023095-4dannjjm 4394 3 analysis analysis NN cord-023095-4dannjjm 4394 4 of of IN cord-023095-4dannjjm 4394 5 feline feline JJ cord-023095-4dannjjm 4394 6 urate urate NN cord-023095-4dannjjm 4394 7 uroliths urolith NNS cord-023095-4dannjjm 4394 8 submitted submit VBN cord-023095-4dannjjm 4394 9 to to IN cord-023095-4dannjjm 4394 10 the the DT cord-023095-4dannjjm 4394 11 Stone Stone NNP cord-023095-4dannjjm 4394 12 Lab Lab NNP cord-023095-4dannjjm 4394 13 between between IN cord-023095-4dannjjm 4394 14 January January NNP cord-023095-4dannjjm 4394 15 2000-December 2000-december CD cord-023095-4dannjjm 4394 16 2008 2008 CD cord-023095-4dannjjm 4394 17 were be VBD cord-023095-4dannjjm 4394 18 included include VBN cord-023095-4dannjjm 4394 19 . . . cord-023095-4dannjjm 4395 1 From from IN cord-023095-4dannjjm 4395 2 these these DT cord-023095-4dannjjm 4395 3 data datum NNS cord-023095-4dannjjm 4395 4 , , , cord-023095-4dannjjm 4395 5 primary primary JJ cord-023095-4dannjjm 4395 6 veterinarians veterinarian NNS cord-023095-4dannjjm 4395 7 were be VBD cord-023095-4dannjjm 4395 8 solicited solicit VBN cord-023095-4dannjjm 4395 9 to to TO cord-023095-4dannjjm 4395 10 submit submit VB cord-023095-4dannjjm 4395 11 records record NNS cord-023095-4dannjjm 4395 12 . . . cord-023095-4dannjjm 4396 1 Furthermore furthermore RB cord-023095-4dannjjm 4396 2 , , , cord-023095-4dannjjm 4396 3 all all DT cord-023095-4dannjjm 4396 4 records record NNS cord-023095-4dannjjm 4396 5 from from IN cord-023095-4dannjjm 4396 6 cats cat NNS cord-023095-4dannjjm 4396 7 with with IN cord-023095-4dannjjm 4396 8 urate urate NN cord-023095-4dannjjm 4396 9 uroliths urolith NNS cord-023095-4dannjjm 4396 10 from from IN cord-023095-4dannjjm 4396 11 the the DT cord-023095-4dannjjm 4396 12 VMTH VMTH NNP cord-023095-4dannjjm 4396 13 were be VBD cord-023095-4dannjjm 4396 14 analyzed analyze VBN cord-023095-4dannjjm 4396 15 separately separately RB cord-023095-4dannjjm 4396 16 . . . cord-023095-4dannjjm 4397 1 143 143 CD cord-023095-4dannjjm 4397 2 records record NNS cord-023095-4dannjjm 4397 3 were be VBD cord-023095-4dannjjm 4397 4 received receive VBN cord-023095-4dannjjm 4397 5 from from IN cord-023095-4dannjjm 4397 6 the the DT cord-023095-4dannjjm 4397 7 primary primary JJ cord-023095-4dannjjm 4397 8 care care NN cord-023095-4dannjjm 4397 9 veterinarians veterinarian NNS cord-023095-4dannjjm 4397 10 . . . cord-023095-4dannjjm 4398 1 Sixteen sixteen CD cord-023095-4dannjjm 4398 2 cases case NNS cord-023095-4dannjjm 4398 3 were be VBD cord-023095-4dannjjm 4398 4 identified identify VBN cord-023095-4dannjjm 4398 5 from from IN cord-023095-4dannjjm 4398 6 the the DT cord-023095-4dannjjm 4398 7 VMTH VMTH NNP cord-023095-4dannjjm 4398 8 . . . cord-023095-4dannjjm 4399 1 Median median JJ cord-023095-4dannjjm 4399 2 values value NNS cord-023095-4dannjjm 4399 3 for for IN cord-023095-4dannjjm 4399 4 the the DT cord-023095-4dannjjm 4399 5 CBC CBC NNP cord-023095-4dannjjm 4399 6 and and CC cord-023095-4dannjjm 4399 7 chemistry chemistry NN cord-023095-4dannjjm 4399 8 panels panel NNS cord-023095-4dannjjm 4399 9 available available JJ cord-023095-4dannjjm 4399 10 were be VBD cord-023095-4dannjjm 4399 11 within within IN cord-023095-4dannjjm 4399 12 the the DT cord-023095-4dannjjm 4399 13 reference reference NN cord-023095-4dannjjm 4399 14 ranges range NNS cord-023095-4dannjjm 4399 15 provided provide VBN cord-023095-4dannjjm 4399 16 , , , cord-023095-4dannjjm 4399 17 with with IN cord-023095-4dannjjm 4399 18 only only RB cord-023095-4dannjjm 4399 19 a a DT cord-023095-4dannjjm 4399 20 few few JJ cord-023095-4dannjjm 4399 21 outliers outlier NNS cord-023095-4dannjjm 4399 22 present present JJ cord-023095-4dannjjm 4399 23 . . . cord-023095-4dannjjm 4400 1 Of of IN cord-023095-4dannjjm 4400 2 the the DT cord-023095-4dannjjm 4400 3 78 78 CD cord-023095-4dannjjm 4400 4 cats cat NNS cord-023095-4dannjjm 4400 5 with with IN cord-023095-4dannjjm 4400 6 radiographic radiographic JJ cord-023095-4dannjjm 4400 7 reports report NNS cord-023095-4dannjjm 4400 8 , , , cord-023095-4dannjjm 4400 9 70 70 CD cord-023095-4dannjjm 4400 10 ( ( -LRB- cord-023095-4dannjjm 4400 11 90 90 CD cord-023095-4dannjjm 4400 12 % % NN cord-023095-4dannjjm 4400 13 ) ) -RRB- cord-023095-4dannjjm 4400 14 had have VBD cord-023095-4dannjjm 4400 15 visible visible JJ cord-023095-4dannjjm 4400 16 evidence evidence NN cord-023095-4dannjjm 4400 17 of of IN cord-023095-4dannjjm 4400 18 uroliths urolith NNS cord-023095-4dannjjm 4400 19 . . . cord-023095-4dannjjm 4401 1 Two two CD cord-023095-4dannjjm 4401 2 external external JJ cord-023095-4dannjjm 4401 3 cases case NNS cord-023095-4dannjjm 4401 4 had have VBD cord-023095-4dannjjm 4401 5 confirmed confirm VBN cord-023095-4dannjjm 4401 6 PSS PSS NNP cord-023095-4dannjjm 4401 7 ; ; : cord-023095-4dannjjm 4401 8 five five CD cord-023095-4dannjjm 4401 9 cases case NNS cord-023095-4dannjjm 4401 10 from from IN cord-023095-4dannjjm 4401 11 the the DT cord-023095-4dannjjm 4401 12 VMTH VMTH NNP cord-023095-4dannjjm 4401 13 had have VBD cord-023095-4dannjjm 4401 14 a a DT cord-023095-4dannjjm 4401 15 PSS PSS NNP cord-023095-4dannjjm 4401 16 . . . cord-023095-4dannjjm 4402 1 Cats cat NNS cord-023095-4dannjjm 4402 2 with with IN cord-023095-4dannjjm 4402 3 urate urate NN cord-023095-4dannjjm 4402 4 uroliths urolith NNS cord-023095-4dannjjm 4402 5 and and CC cord-023095-4dannjjm 4402 6 PSS PSS NNP cord-023095-4dannjjm 4402 7 were be VBD cord-023095-4dannjjm 4402 8 younger young JJR cord-023095-4dannjjm 4402 9 than than IN cord-023095-4dannjjm 4402 10 cats cat NNS cord-023095-4dannjjm 4402 11 without without IN cord-023095-4dannjjm 4402 12 a a DT cord-023095-4dannjjm 4402 13 documented document VBN cord-023095-4dannjjm 4402 14 hepatopathy hepatopathy NN cord-023095-4dannjjm 4402 15 ( ( -LRB- cord-023095-4dannjjm 4402 16 2 2 CD cord-023095-4dannjjm 4402 17 years year NNS cord-023095-4dannjjm 4402 18 vs. vs. IN cord-023095-4dannjjm 4402 19 7 7 CD cord-023095-4dannjjm 4402 20 years year NNS cord-023095-4dannjjm 4402 21 ) ) -RRB- cord-023095-4dannjjm 4402 22 . . . cord-023095-4dannjjm 4403 1 The the DT cord-023095-4dannjjm 4403 2 Siamese siamese JJ cord-023095-4dannjjm 4403 3 breed breed NN cord-023095-4dannjjm 4403 4 was be VBD cord-023095-4dannjjm 4403 5 overrepresented overrepresente VBN cord-023095-4dannjjm 4403 6 . . . cord-023095-4dannjjm 4404 1 All all DT cord-023095-4dannjjm 4404 2 stones stone NNS cord-023095-4dannjjm 4404 3 were be VBD cord-023095-4dannjjm 4404 4 ammonium ammonium NN cord-023095-4dannjjm 4404 5 hydrogen hydrogen NN cord-023095-4dannjjm 4404 6 urate urate NN cord-023095-4dannjjm 4404 7 . . . cord-023095-4dannjjm 4405 1 The the DT cord-023095-4dannjjm 4405 2 pathogensis pathogensis NN cord-023095-4dannjjm 4405 3 of of IN cord-023095-4dannjjm 4405 4 urate urate NN cord-023095-4dannjjm 4405 5 uroliths urolith NNS cord-023095-4dannjjm 4405 6 in in IN cord-023095-4dannjjm 4405 7 cats cat NNS cord-023095-4dannjjm 4405 8 is be VBZ cord-023095-4dannjjm 4405 9 poorly poorly RB cord-023095-4dannjjm 4405 10 understood understand VBN cord-023095-4dannjjm 4405 11 . . . cord-023095-4dannjjm 4406 1 Most Most JJS cord-023095-4dannjjm 4406 2 cats cat NNS cord-023095-4dannjjm 4406 3 were be VBD cord-023095-4dannjjm 4406 4 not not RB cord-023095-4dannjjm 4406 5 completely completely RB cord-023095-4dannjjm 4406 6 evaluated evaluate VBN cord-023095-4dannjjm 4406 7 for for IN cord-023095-4dannjjm 4406 8 PSS PSS NNP cord-023095-4dannjjm 4406 9 , , , cord-023095-4dannjjm 4406 10 however however RB cord-023095-4dannjjm 4406 11 , , , cord-023095-4dannjjm 4406 12 there there EX cord-023095-4dannjjm 4406 13 were be VBD cord-023095-4dannjjm 4406 14 few few JJ cord-023095-4dannjjm 4406 15 clinicopathologic clinicopathologic JJ cord-023095-4dannjjm 4406 16 parameters parameter NNS cord-023095-4dannjjm 4406 17 which which WDT cord-023095-4dannjjm 4406 18 indicated indicate VBD cord-023095-4dannjjm 4406 19 hepatopathies hepatopathie NNS cord-023095-4dannjjm 4406 20 were be VBD cord-023095-4dannjjm 4406 21 present present JJ cord-023095-4dannjjm 4406 22 . . . cord-023095-4dannjjm 4407 1 Further further JJ cord-023095-4dannjjm 4407 2 studies study NNS cord-023095-4dannjjm 4407 3 are be VBP cord-023095-4dannjjm 4407 4 warranted warrant VBN cord-023095-4dannjjm 4407 5 to to TO cord-023095-4dannjjm 4407 6 evaluate evaluate VB cord-023095-4dannjjm 4407 7 genetics genetic NNS cord-023095-4dannjjm 4407 8 and and CC cord-023095-4dannjjm 4407 9 purine purine NN cord-023095-4dannjjm 4407 10 metabolism metabolism NN cord-023095-4dannjjm 4407 11 in in IN cord-023095-4dannjjm 4407 12 cats cat NNS cord-023095-4dannjjm 4407 13 with with IN cord-023095-4dannjjm 4407 14 urate urate NN cord-023095-4dannjjm 4407 15 uroliths urolith NNS cord-023095-4dannjjm 4407 16 to to TO cord-023095-4dannjjm 4407 17 help help VB cord-023095-4dannjjm 4407 18 tailor tailor VB cord-023095-4dannjjm 4407 19 proper proper JJ cord-023095-4dannjjm 4407 20 management management NN cord-023095-4dannjjm 4407 21 and and CC cord-023095-4dannjjm 4407 22 breeding breeding NN cord-023095-4dannjjm 4407 23 strategies strategy NNS cord-023095-4dannjjm 4407 24 . . . cord-023095-4dannjjm 4408 1 3-Indoxyl 3-Indoxyl NNP cord-023095-4dannjjm 4408 2 and and CC cord-023095-4dannjjm 4408 3 p p NN cord-023095-4dannjjm 4408 4 - - HYPH cord-023095-4dannjjm 4408 5 cresyl cresyl NN cord-023095-4dannjjm 4408 6 sulfate sulfate NN cord-023095-4dannjjm 4408 7 ( ( -LRB- cord-023095-4dannjjm 4408 8 IS be VBZ cord-023095-4dannjjm 4408 9 , , , cord-023095-4dannjjm 4408 10 and and CC cord-023095-4dannjjm 4408 11 CS CS NNP cord-023095-4dannjjm 4408 12 , , , cord-023095-4dannjjm 4408 13 respectively respectively RB cord-023095-4dannjjm 4408 14 ) ) -RRB- cord-023095-4dannjjm 4408 15 , , , cord-023095-4dannjjm 4408 16 small small JJ cord-023095-4dannjjm 4408 17 protein protein NN cord-023095-4dannjjm 4408 18 - - HYPH cord-023095-4dannjjm 4408 19 bound bind VBN cord-023095-4dannjjm 4408 20 molecules molecule NNS cord-023095-4dannjjm 4408 21 derived derive VBN cord-023095-4dannjjm 4408 22 from from IN cord-023095-4dannjjm 4408 23 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 4408 24 protein protein NN cord-023095-4dannjjm 4408 25 metabolism metabolism NN cord-023095-4dannjjm 4408 26 , , , cord-023095-4dannjjm 4408 27 are be VBP cord-023095-4dannjjm 4408 28 among among IN cord-023095-4dannjjm 4408 29 the the DT cord-023095-4dannjjm 4408 30 most most RBS cord-023095-4dannjjm 4408 31 important important JJ cord-023095-4dannjjm 4408 32 uremic uremic JJ cord-023095-4dannjjm 4408 33 solutes solute NNS cord-023095-4dannjjm 4408 34 affecting affect VBG cord-023095-4dannjjm 4408 35 morbidity morbidity NN cord-023095-4dannjjm 4408 36 and and CC cord-023095-4dannjjm 4408 37 mortality mortality NN cord-023095-4dannjjm 4408 38 in in IN cord-023095-4dannjjm 4408 39 human human JJ cord-023095-4dannjjm 4408 40 chronic chronic JJ cord-023095-4dannjjm 4408 41 kidney kidney NN cord-023095-4dannjjm 4408 42 disease disease NN cord-023095-4dannjjm 4408 43 ( ( -LRB- cord-023095-4dannjjm 4408 44 CKD CKD NNP cord-023095-4dannjjm 4408 45 ) ) -RRB- cord-023095-4dannjjm 4408 46 . . . cord-023095-4dannjjm 4409 1 In in IN cord-023095-4dannjjm 4409 2 the the DT cord-023095-4dannjjm 4409 3 blood blood NN cord-023095-4dannjjm 4409 4 stream stream NN cord-023095-4dannjjm 4409 5 , , , cord-023095-4dannjjm 4409 6 these these DT cord-023095-4dannjjm 4409 7 compounds compound NNS cord-023095-4dannjjm 4409 8 are be VBP cord-023095-4dannjjm 4409 9 predominantly predominantly RB cord-023095-4dannjjm 4409 10 bound bind VBN cord-023095-4dannjjm 4409 11 to to IN cord-023095-4dannjjm 4409 12 protein protein NN cord-023095-4dannjjm 4409 13 , , , cord-023095-4dannjjm 4409 14 but but CC cord-023095-4dannjjm 4409 15 their -PRON- PRP$ cord-023095-4dannjjm 4409 16 debilitating debilitating JJ cord-023095-4dannjjm 4409 17 effects effect NNS cord-023095-4dannjjm 4409 18 on on IN cord-023095-4dannjjm 4409 19 prognosis prognosis NN cord-023095-4dannjjm 4409 20 and and CC cord-023095-4dannjjm 4409 21 quality quality NN cord-023095-4dannjjm 4409 22 of of IN cord-023095-4dannjjm 4409 23 life life NN cord-023095-4dannjjm 4409 24 in in IN cord-023095-4dannjjm 4409 25 CKD CKD NNP cord-023095-4dannjjm 4409 26 appear appear VBP cord-023095-4dannjjm 4409 27 to to TO cord-023095-4dannjjm 4409 28 be be VB cord-023095-4dannjjm 4409 29 driven drive VBN cord-023095-4dannjjm 4409 30 by by IN cord-023095-4dannjjm 4409 31 the the DT cord-023095-4dannjjm 4409 32 free free JJ cord-023095-4dannjjm 4409 33 fraction fraction NN cord-023095-4dannjjm 4409 34 . . . cord-023095-4dannjjm 4410 1 The the DT cord-023095-4dannjjm 4410 2 objectives objective NNS cord-023095-4dannjjm 4410 3 of of IN cord-023095-4dannjjm 4410 4 the the DT cord-023095-4dannjjm 4410 5 present present JJ cord-023095-4dannjjm 4410 6 study study NN cord-023095-4dannjjm 4410 7 were be VBD cord-023095-4dannjjm 4410 8 to to TO cord-023095-4dannjjm 4410 9 assess assess VB cord-023095-4dannjjm 4410 10 the the DT cord-023095-4dannjjm 4410 11 normal normal JJ cord-023095-4dannjjm 4410 12 , , , cord-023095-4dannjjm 4410 13 physiological physiological JJ cord-023095-4dannjjm 4410 14 levels level NNS cord-023095-4dannjjm 4410 15 of of IN cord-023095-4dannjjm 4410 16 IS is NN cord-023095-4dannjjm 4410 17 and and CC cord-023095-4dannjjm 4410 18 CS CS NNP cord-023095-4dannjjm 4410 19 in in IN cord-023095-4dannjjm 4410 20 healthy healthy JJ cord-023095-4dannjjm 4410 21 cats cat NNS cord-023095-4dannjjm 4410 22 and and CC cord-023095-4dannjjm 4410 23 to to TO cord-023095-4dannjjm 4410 24 evaluate evaluate VB cord-023095-4dannjjm 4410 25 the the DT cord-023095-4dannjjm 4410 26 correlation correlation NN cord-023095-4dannjjm 4410 27 of of IN cord-023095-4dannjjm 4410 28 the the DT cord-023095-4dannjjm 4410 29 respective respective JJ cord-023095-4dannjjm 4410 30 free free JJ cord-023095-4dannjjm 4410 31 and and CC cord-023095-4dannjjm 4410 32 protein protein NN cord-023095-4dannjjm 4410 33 - - HYPH cord-023095-4dannjjm 4410 34 bound bind VBN cord-023095-4dannjjm 4410 35 levels level NNS cord-023095-4dannjjm 4410 36 . . . cord-023095-4dannjjm 4411 1 Blood blood NN cord-023095-4dannjjm 4411 2 samples sample NNS cord-023095-4dannjjm 4411 3 were be VBD cord-023095-4dannjjm 4411 4 taken take VBN cord-023095-4dannjjm 4411 5 from from IN cord-023095-4dannjjm 4411 6 105 105 CD cord-023095-4dannjjm 4411 7 clinically clinically RB cord-023095-4dannjjm 4411 8 healthy healthy JJ cord-023095-4dannjjm 4411 9 adult adult NN cord-023095-4dannjjm 4411 10 cats cat NNS cord-023095-4dannjjm 4411 11 enrolled enrol VBD cord-023095-4dannjjm 4411 12 at at IN cord-023095-4dannjjm 4411 13 five five CD cord-023095-4dannjjm 4411 14 participating participate VBG cord-023095-4dannjjm 4411 15 veterinary veterinary JJ cord-023095-4dannjjm 4411 16 practices practice NNS cord-023095-4dannjjm 4411 17 in in IN cord-023095-4dannjjm 4411 18 Germany Germany NNP cord-023095-4dannjjm 4411 19 . . . cord-023095-4dannjjm 4412 1 After after IN cord-023095-4dannjjm 4412 2 centrifugation centrifugation NN cord-023095-4dannjjm 4412 3 , , , cord-023095-4dannjjm 4412 4 the the DT cord-023095-4dannjjm 4412 5 serum serum NN cord-023095-4dannjjm 4412 6 was be VBD cord-023095-4dannjjm 4412 7 deep deep JJ cord-023095-4dannjjm 4412 8 frozen frozen JJ cord-023095-4dannjjm 4412 9 until until IN cord-023095-4dannjjm 4412 10 transport transport NN cord-023095-4dannjjm 4412 11 on on IN cord-023095-4dannjjm 4412 12 dry dry JJ cord-023095-4dannjjm 4412 13 ice ice NN cord-023095-4dannjjm 4412 14 to to IN cord-023095-4dannjjm 4412 15 the the DT cord-023095-4dannjjm 4412 16 analytical analytical JJ cord-023095-4dannjjm 4412 17 laboratory laboratory NN cord-023095-4dannjjm 4412 18 . . . cord-023095-4dannjjm 4413 1 Serum serum NN cord-023095-4dannjjm 4413 2 creatinine creatinine NN cord-023095-4dannjjm 4413 3 and and CC cord-023095-4dannjjm 4413 4 urea urea NN cord-023095-4dannjjm 4413 5 levels level NNS cord-023095-4dannjjm 4413 6 were be VBD cord-023095-4dannjjm 4413 7 quantified quantify VBN cord-023095-4dannjjm 4413 8 by by IN cord-023095-4dannjjm 4413 9 VetTest VetTest NNP cord-023095-4dannjjm 4413 10 s s NNP cord-023095-4dannjjm 4413 11 ( ( -LRB- cord-023095-4dannjjm 4413 12 IDEXX IDEXX NNP cord-023095-4dannjjm 4413 13 Laboratories Laboratories NNP cord-023095-4dannjjm 4413 14 , , , cord-023095-4dannjjm 4413 15 Inc. Inc. NNP cord-023095-4dannjjm 4413 16 ) ) -RRB- cord-023095-4dannjjm 4413 17 . . . cord-023095-4dannjjm 4414 1 Total total JJ cord-023095-4dannjjm 4414 2 and and CC cord-023095-4dannjjm 4414 3 free free JJ cord-023095-4dannjjm 4414 4 IS is NN cord-023095-4dannjjm 4414 5 and and CC cord-023095-4dannjjm 4414 6 CS CS NNP cord-023095-4dannjjm 4414 7 , , , cord-023095-4dannjjm 4414 8 respectively respectively RB cord-023095-4dannjjm 4414 9 , , , cord-023095-4dannjjm 4414 10 were be VBD cord-023095-4dannjjm 4414 11 quantified quantify VBN cord-023095-4dannjjm 4414 12 by by IN cord-023095-4dannjjm 4414 13 turbulent turbulent JJ cord-023095-4dannjjm 4414 14 flow flow NN cord-023095-4dannjjm 4414 15 chromatography chromatography NN cord-023095-4dannjjm 4414 16 coupled couple VBN cord-023095-4dannjjm 4414 17 with with IN cord-023095-4dannjjm 4414 18 a a DT cord-023095-4dannjjm 4414 19 tandem tandem JJ cord-023095-4dannjjm 4414 20 mass mass NN cord-023095-4dannjjm 4414 21 spectrometry spectrometry NN cord-023095-4dannjjm 4414 22 detector detector NN cord-023095-4dannjjm 4414 23 . . . cord-023095-4dannjjm 4415 1 Statistical statistical JJ cord-023095-4dannjjm 4415 2 analysis analysis NN cord-023095-4dannjjm 4415 3 of of IN cord-023095-4dannjjm 4415 4 the the DT cord-023095-4dannjjm 4415 5 results result NNS cord-023095-4dannjjm 4415 6 comprised comprise VBN cord-023095-4dannjjm 4415 7 i i NN cord-023095-4dannjjm 4415 8 ) ) -RRB- cord-023095-4dannjjm 4415 9 a a DT cord-023095-4dannjjm 4415 10 descriptive descriptive JJ cord-023095-4dannjjm 4415 11 report report NN cord-023095-4dannjjm 4415 12 of of IN cord-023095-4dannjjm 4415 13 the the DT cord-023095-4dannjjm 4415 14 median median NN cord-023095-4dannjjm 4415 15 with with IN cord-023095-4dannjjm 4415 16 upper upper JJ cord-023095-4dannjjm 4415 17 and and CC cord-023095-4dannjjm 4415 18 lower low JJR cord-023095-4dannjjm 4415 19 bounds bound NNS cord-023095-4dannjjm 4415 20 of of IN cord-023095-4dannjjm 4415 21 the the DT cord-023095-4dannjjm 4415 22 95 95 CD cord-023095-4dannjjm 4415 23 % % NN cord-023095-4dannjjm 4415 24 confidence confidence NN cord-023095-4dannjjm 4415 25 interval interval NN cord-023095-4dannjjm 4415 26 for for IN cord-023095-4dannjjm 4415 27 reference reference NN cord-023095-4dannjjm 4415 28 values value NNS cord-023095-4dannjjm 4415 29 of of IN cord-023095-4dannjjm 4415 30 IS is NN cord-023095-4dannjjm 4415 31 and and CC cord-023095-4dannjjm 4415 32 CS CS NNP cord-023095-4dannjjm 4415 33 , , , cord-023095-4dannjjm 4415 34 ii ii LS cord-023095-4dannjjm 4415 35 ) ) -RRB- cord-023095-4dannjjm 4415 36 a a DT cord-023095-4dannjjm 4415 37 calculation calculation NN cord-023095-4dannjjm 4415 38 of of IN cord-023095-4dannjjm 4415 39 various various JJ cord-023095-4dannjjm 4415 40 Pearson Pearson NNP cord-023095-4dannjjm 4415 41 correlation correlation NN cord-023095-4dannjjm 4415 42 coefficients coefficient NNS cord-023095-4dannjjm 4415 43 r r NN cord-023095-4dannjjm 4415 44 , , , cord-023095-4dannjjm 4415 45 also also RB cord-023095-4dannjjm 4415 46 tested test VBN cord-023095-4dannjjm 4415 47 with with IN cord-023095-4dannjjm 4415 48 reference reference NN cord-023095-4dannjjm 4415 49 to to IN cord-023095-4dannjjm 4415 50 the the DT cord-023095-4dannjjm 4415 51 null null JJ cord-023095-4dannjjm 4415 52 hypothesis hypothesis NN cord-023095-4dannjjm 4415 53 of of IN cord-023095-4dannjjm 4415 54 no no DT cord-023095-4dannjjm 4415 55 relationship relationship NN cord-023095-4dannjjm 4415 56 , , , cord-023095-4dannjjm 4415 57 and and CC cord-023095-4dannjjm 4415 58 iii iii LS cord-023095-4dannjjm 4415 59 ) ) -RRB- cord-023095-4dannjjm 4416 1 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 4416 2 - - HYPH cord-023095-4dannjjm 4416 3 Mann Mann NNP cord-023095-4dannjjm 4416 4 - - HYPH cord-023095-4dannjjm 4416 5 Whitney Whitney NNP cord-023095-4dannjjm 4416 6 Utest Utest NNP cord-023095-4dannjjm 4416 7 for for IN cord-023095-4dannjjm 4416 8 an an DT cord-023095-4dannjjm 4416 9 estimation estimation NN cord-023095-4dannjjm 4416 10 of of IN cord-023095-4dannjjm 4416 11 the the DT cord-023095-4dannjjm 4416 12 effect effect NN cord-023095-4dannjjm 4416 13 of of IN cord-023095-4dannjjm 4416 14 hemolysis hemolysis NN cord-023095-4dannjjm 4416 15 on on IN cord-023095-4dannjjm 4416 16 serum serum NN cord-023095-4dannjjm 4416 17 IS be VBZ cord-023095-4dannjjm 4416 18 or or CC cord-023095-4dannjjm 4416 19 CS CS NNP cord-023095-4dannjjm 4416 20 levels level NNS cord-023095-4dannjjm 4416 21 . . . cord-023095-4dannjjm 4417 1 Six six CD cord-023095-4dannjjm 4417 2 animals animal NNS cord-023095-4dannjjm 4417 3 with with IN cord-023095-4dannjjm 4417 4 serum serum NN cord-023095-4dannjjm 4417 5 creatinine creatinine NN cord-023095-4dannjjm 4417 6 or or CC cord-023095-4dannjjm 4417 7 urea urea NN cord-023095-4dannjjm 4417 8 levels level NNS cord-023095-4dannjjm 4417 9 outside outside IN cord-023095-4dannjjm 4417 10 the the DT cord-023095-4dannjjm 4417 11 reference reference NN cord-023095-4dannjjm 4417 12 range range NN cord-023095-4dannjjm 4417 13 were be VBD cord-023095-4dannjjm 4417 14 excluded exclude VBN cord-023095-4dannjjm 4417 15 from from IN cord-023095-4dannjjm 4417 16 the the DT cord-023095-4dannjjm 4417 17 calculation calculation NN cord-023095-4dannjjm 4417 18 of of IN cord-023095-4dannjjm 4417 19 reference reference NN cord-023095-4dannjjm 4417 20 values value NNS cord-023095-4dannjjm 4417 21 . . . cord-023095-4dannjjm 4418 1 Median median JJ cord-023095-4dannjjm 4418 2 levels level NNS cord-023095-4dannjjm 4418 3 of of IN cord-023095-4dannjjm 4418 4 IS is NN cord-023095-4dannjjm 4418 5 in in IN cord-023095-4dannjjm 4418 6 cat cat NN cord-023095-4dannjjm 4418 7 serum serum NN cord-023095-4dannjjm 4418 8 were be VBD cord-023095-4dannjjm 4418 9 1.19 1.19 CD cord-023095-4dannjjm 4418 10 mg mg NNP cord-023095-4dannjjm 4418 11 / / SYM cord-023095-4dannjjm 4418 12 L L NNP cord-023095-4dannjjm 4418 13 with with IN cord-023095-4dannjjm 4418 14 upper upper JJ cord-023095-4dannjjm 4418 15 and and CC cord-023095-4dannjjm 4418 16 lower lower RBR cord-023095-4dannjjm 4418 17 bound bind VBN cord-023095-4dannjjm 4418 18 95 95 CD cord-023095-4dannjjm 4418 19 % % NN cord-023095-4dannjjm 4418 20 confidence confidence NN cord-023095-4dannjjm 4418 21 intervals interval NNS cord-023095-4dannjjm 4418 22 at at IN cord-023095-4dannjjm 4418 23 1.46 1.46 CD cord-023095-4dannjjm 4418 24 and and CC cord-023095-4dannjjm 4418 25 0.99 0.99 CD cord-023095-4dannjjm 4418 26 mg mg NNP cord-023095-4dannjjm 4418 27 / / SYM cord-023095-4dannjjm 4418 28 L L NNP cord-023095-4dannjjm 4418 29 , , , cord-023095-4dannjjm 4418 30 respectively respectively RB cord-023095-4dannjjm 4418 31 . . . cord-023095-4dannjjm 4419 1 The the DT cord-023095-4dannjjm 4419 2 corresponding correspond VBG cord-023095-4dannjjm 4419 3 median median JJ cord-023095-4dannjjm 4419 4 levels level NNS cord-023095-4dannjjm 4419 5 of of IN cord-023095-4dannjjm 4419 6 CS CS NNP cord-023095-4dannjjm 4419 7 were be VBD cord-023095-4dannjjm 4419 8 2.11 2.11 CD cord-023095-4dannjjm 4419 9 mg mg NNP cord-023095-4dannjjm 4419 10 / / SYM cord-023095-4dannjjm 4419 11 L L NNP cord-023095-4dannjjm 4419 12 ( ( -LRB- cord-023095-4dannjjm 4419 13 median median NN cord-023095-4dannjjm 4419 14 ) ) -RRB- cord-023095-4dannjjm 4419 15 and and CC cord-023095-4dannjjm 4419 16 2.46 2.46 CD cord-023095-4dannjjm 4419 17 vs vs IN cord-023095-4dannjjm 4419 18 1.57 1.57 CD cord-023095-4dannjjm 4419 19 mg mg NNP cord-023095-4dannjjm 4419 20 / / SYM cord-023095-4dannjjm 4419 21 L L NNP cord-023095-4dannjjm 4419 22 ( ( -LRB- cord-023095-4dannjjm 4419 23 upper upper JJ cord-023095-4dannjjm 4419 24 vs vs IN cord-023095-4dannjjm 4419 25 lower lower RBR cord-023095-4dannjjm 4419 26 bound bound JJ cord-023095-4dannjjm 4419 27 levels level NNS cord-023095-4dannjjm 4419 28 , , , cord-023095-4dannjjm 4419 29 respectively respectively RB cord-023095-4dannjjm 4419 30 ) ) -RRB- cord-023095-4dannjjm 4419 31 . . . cord-023095-4dannjjm 4420 1 These these DT cord-023095-4dannjjm 4420 2 values value NNS cord-023095-4dannjjm 4420 3 showed show VBD cord-023095-4dannjjm 4420 4 a a DT cord-023095-4dannjjm 4420 5 low low JJ cord-023095-4dannjjm 4420 6 , , , cord-023095-4dannjjm 4420 7 non non JJ cord-023095-4dannjjm 4420 8 - - JJ cord-023095-4dannjjm 4420 9 significant significant JJ cord-023095-4dannjjm 4420 10 correlation correlation NN cord-023095-4dannjjm 4420 11 with with IN cord-023095-4dannjjm 4420 12 serum serum NN cord-023095-4dannjjm 4420 13 creatinine creatinine NN cord-023095-4dannjjm 4420 14 or or CC cord-023095-4dannjjm 4420 15 urea urea NN cord-023095-4dannjjm 4420 16 levels level NNS cord-023095-4dannjjm 4420 17 . . . cord-023095-4dannjjm 4421 1 However however RB cord-023095-4dannjjm 4421 2 , , , cord-023095-4dannjjm 4421 3 IS be VBZ cord-023095-4dannjjm 4421 4 and and CC cord-023095-4dannjjm 4421 5 CS CS NNP cord-023095-4dannjjm 4421 6 serum serum NN cord-023095-4dannjjm 4421 7 levels level NNS cord-023095-4dannjjm 4421 8 were be VBD cord-023095-4dannjjm 4421 9 moderately moderately RB cord-023095-4dannjjm 4421 10 correlated correlate VBN cord-023095-4dannjjm 4421 11 ( ( -LRB- cord-023095-4dannjjm 4421 12 total total JJ cord-023095-4dannjjm 4421 13 levels level NNS cord-023095-4dannjjm 4421 14 r r NNP cord-023095-4dannjjm 4421 15 5 5 CD cord-023095-4dannjjm 4421 16 0.4808 0.4808 CD cord-023095-4dannjjm 4421 17 , , , cord-023095-4dannjjm 4421 18 p p NN cord-023095-4dannjjm 4421 19 o o NN cord-023095-4dannjjm 4421 20 0001 0001 CD cord-023095-4dannjjm 4421 21 ) ) -RRB- cord-023095-4dannjjm 4421 22 . . . cord-023095-4dannjjm 4422 1 Their -PRON- PRP$ cord-023095-4dannjjm 4422 2 respective respective JJ cord-023095-4dannjjm 4422 3 free free JJ cord-023095-4dannjjm 4422 4 levels level NNS cord-023095-4dannjjm 4422 5 constituted constitute VBN cord-023095-4dannjjm 4422 6 about about RB cord-023095-4dannjjm 4422 7 5 5 CD cord-023095-4dannjjm 4422 8 % % NN cord-023095-4dannjjm 4422 9 of of IN cord-023095-4dannjjm 4422 10 the the DT cord-023095-4dannjjm 4422 11 total total JJ cord-023095-4dannjjm 4422 12 serum serum NN cord-023095-4dannjjm 4422 13 levels level NNS cord-023095-4dannjjm 4422 14 ( ( -LRB- cord-023095-4dannjjm 4422 15 r r NN cord-023095-4dannjjm 4422 16 ! ! . cord-023095-4dannjjm 4422 17 0.8977 0.8977 CD cord-023095-4dannjjm 4422 18 , , , cord-023095-4dannjjm 4422 19 p p NN cord-023095-4dannjjm 4422 20 o o NN cord-023095-4dannjjm 4422 21 0.001 0.001 CD cord-023095-4dannjjm 4422 22 ) ) -RRB- cord-023095-4dannjjm 4422 23 . . . cord-023095-4dannjjm 4423 1 Non non JJ cord-023095-4dannjjm 4423 2 - - JJ cord-023095-4dannjjm 4423 3 hemolytic hemolytic JJ cord-023095-4dannjjm 4423 4 samples sample NNS cord-023095-4dannjjm 4423 5 tended tend VBD cord-023095-4dannjjm 4423 6 to to TO cord-023095-4dannjjm 4423 7 yield yield VB cord-023095-4dannjjm 4423 8 lower low JJR cord-023095-4dannjjm 4423 9 values value NNS cord-023095-4dannjjm 4423 10 than than IN cord-023095-4dannjjm 4423 11 hemolytic hemolytic JJ cord-023095-4dannjjm 4423 12 samples sample NNS cord-023095-4dannjjm 4423 13 . . . cord-023095-4dannjjm 4424 1 Due due IN cord-023095-4dannjjm 4424 2 to to IN cord-023095-4dannjjm 4424 3 the the DT cord-023095-4dannjjm 4424 4 low low JJ cord-023095-4dannjjm 4424 5 number number NN cord-023095-4dannjjm 4424 6 of of IN cord-023095-4dannjjm 4424 7 hemolytic hemolytic JJ cord-023095-4dannjjm 4424 8 samples sample NNS cord-023095-4dannjjm 4424 9 ( ( -LRB- cord-023095-4dannjjm 4424 10 N n CD cord-023095-4dannjjm 4424 11 5 5 CD cord-023095-4dannjjm 4424 12 14 14 CD cord-023095-4dannjjm 4424 13 ) ) -RRB- cord-023095-4dannjjm 4424 14 , , , cord-023095-4dannjjm 4424 15 the the DT cord-023095-4dannjjm 4424 16 group group NN cord-023095-4dannjjm 4424 17 difference difference NN cord-023095-4dannjjm 4424 18 could could MD cord-023095-4dannjjm 4424 19 , , , cord-023095-4dannjjm 4424 20 however however RB cord-023095-4dannjjm 4424 21 , , , cord-023095-4dannjjm 4424 22 not not RB cord-023095-4dannjjm 4424 23 be be VB cord-023095-4dannjjm 4424 24 statistically statistically RB cord-023095-4dannjjm 4424 25 confirmed confirm VBN cord-023095-4dannjjm 4424 26 . . . cord-023095-4dannjjm 4425 1 The the DT cord-023095-4dannjjm 4425 2 results result NNS cord-023095-4dannjjm 4425 3 indicate indicate VBP cord-023095-4dannjjm 4425 4 that that IN cord-023095-4dannjjm 4425 5 it -PRON- PRP cord-023095-4dannjjm 4425 6 is be VBZ cord-023095-4dannjjm 4425 7 sufficient sufficient JJ cord-023095-4dannjjm 4425 8 to to TO cord-023095-4dannjjm 4425 9 determine determine VB cord-023095-4dannjjm 4425 10 total total JJ cord-023095-4dannjjm 4425 11 levels level NNS cord-023095-4dannjjm 4425 12 of of IN cord-023095-4dannjjm 4425 13 either either DT cord-023095-4dannjjm 4425 14 IS be VBZ cord-023095-4dannjjm 4425 15 or or CC cord-023095-4dannjjm 4425 16 CS CS NNP cord-023095-4dannjjm 4425 17 in in IN cord-023095-4dannjjm 4425 18 serum serum NN cord-023095-4dannjjm 4425 19 while while IN cord-023095-4dannjjm 4425 20 studying study VBG cord-023095-4dannjjm 4425 21 the the DT cord-023095-4dannjjm 4425 22 effects effect NNS cord-023095-4dannjjm 4425 23 of of IN cord-023095-4dannjjm 4425 24 therapeutic therapeutic JJ cord-023095-4dannjjm 4425 25 or or CC cord-023095-4dannjjm 4425 26 dietetic dietetic JJ cord-023095-4dannjjm 4425 27 interventions intervention NNS cord-023095-4dannjjm 4425 28 on on IN cord-023095-4dannjjm 4425 29 the the DT cord-023095-4dannjjm 4425 30 evolution evolution NN cord-023095-4dannjjm 4425 31 of of IN cord-023095-4dannjjm 4425 32 these these DT cord-023095-4dannjjm 4425 33 parameters parameter NNS cord-023095-4dannjjm 4425 34 in in IN cord-023095-4dannjjm 4425 35 feline feline JJ cord-023095-4dannjjm 4425 36 CKD CKD NNP cord-023095-4dannjjm 4425 37 . . . cord-023095-4dannjjm 4426 1 Reference reference NN cord-023095-4dannjjm 4426 2 values value NNS cord-023095-4dannjjm 4426 3 are be VBP cord-023095-4dannjjm 4426 4 provided provide VBN cord-023095-4dannjjm 4426 5 for for IN cord-023095-4dannjjm 4426 6 orientation orientation NN cord-023095-4dannjjm 4426 7 towards towards IN cord-023095-4dannjjm 4426 8 clinically clinically RB cord-023095-4dannjjm 4426 9 relevant relevant JJ cord-023095-4dannjjm 4426 10 changes change NNS cord-023095-4dannjjm 4426 11 . . . cord-023095-4dannjjm 4427 1 Disrupted disrupt VBN cord-023095-4dannjjm 4427 2 urothelial urothelial JJ cord-023095-4dannjjm 4427 3 differentiation differentiation NN cord-023095-4dannjjm 4427 4 has have VBZ cord-023095-4dannjjm 4427 5 been be VBN cord-023095-4dannjjm 4427 6 implicated implicate VBN cord-023095-4dannjjm 4427 7 in in IN cord-023095-4dannjjm 4427 8 the the DT cord-023095-4dannjjm 4427 9 pathogenesis pathogenesis NN cord-023095-4dannjjm 4427 10 of of IN cord-023095-4dannjjm 4427 11 feline feline JJ cord-023095-4dannjjm 4427 12 idiopathic idiopathic JJ cord-023095-4dannjjm 4427 13 cystitis cystitis NN cord-023095-4dannjjm 4427 14 ( ( -LRB- cord-023095-4dannjjm 4427 15 FIC fic NN cord-023095-4dannjjm 4427 16 ) ) -RRB- cord-023095-4dannjjm 4427 17 . . . cord-023095-4dannjjm 4428 1 Studies study NNS cord-023095-4dannjjm 4428 2 of of IN cord-023095-4dannjjm 4428 3 cultured cultured JJ cord-023095-4dannjjm 4428 4 human human JJ cord-023095-4dannjjm 4428 5 urothelium urothelium NN cord-023095-4dannjjm 4428 6 have have VBP cord-023095-4dannjjm 4428 7 shown show VBN cord-023095-4dannjjm 4428 8 that that IN cord-023095-4dannjjm 4428 9 abnormalities abnormality NNS cord-023095-4dannjjm 4428 10 in in IN cord-023095-4dannjjm 4428 11 urothelial urothelial JJ cord-023095-4dannjjm 4428 12 differentiation differentiation NN cord-023095-4dannjjm 4428 13 and and CC cord-023095-4dannjjm 4428 14 repair repair NN cord-023095-4dannjjm 4428 15 may may MD cord-023095-4dannjjm 4428 16 be be VB cord-023095-4dannjjm 4428 17 mediated mediate VBN cord-023095-4dannjjm 4428 18 by by IN cord-023095-4dannjjm 4428 19 persistent persistent JJ cord-023095-4dannjjm 4428 20 15-hydroxy 15-hydroxy CD cord-023095-4dannjjm 4428 21 - - HYPH cord-023095-4dannjjm 4428 22 prostaglandin prostaglandin NN cord-023095-4dannjjm 4428 23 dehydrogenase dehydrogenase NN cord-023095-4dannjjm 4428 24 ( ( -LRB- cord-023095-4dannjjm 4428 25 PGDH PGDH NNP cord-023095-4dannjjm 4428 26 ) ) -RRB- cord-023095-4dannjjm 4428 27 activity activity NN cord-023095-4dannjjm 4428 28 and and CC cord-023095-4dannjjm 4428 29 subsequent subsequent JJ cord-023095-4dannjjm 4428 30 metabolism metabolism NN cord-023095-4dannjjm 4428 31 of of IN cord-023095-4dannjjm 4428 32 cytoprotective cytoprotective JJ cord-023095-4dannjjm 4428 33 prostaglandins prostaglandin NNS cord-023095-4dannjjm 4428 34 . . . cord-023095-4dannjjm 4429 1 The the DT cord-023095-4dannjjm 4429 2 goal goal NN cord-023095-4dannjjm 4429 3 of of IN cord-023095-4dannjjm 4429 4 this this DT cord-023095-4dannjjm 4429 5 study study NN cord-023095-4dannjjm 4429 6 was be VBD cord-023095-4dannjjm 4429 7 to to TO cord-023095-4dannjjm 4429 8 confirm confirm VB cord-023095-4dannjjm 4429 9 persistent persistent JJ cord-023095-4dannjjm 4429 10 PGDH PGDH NNP cord-023095-4dannjjm 4429 11 expression expression NN cord-023095-4dannjjm 4429 12 in in IN cord-023095-4dannjjm 4429 13 FIC fic NN cord-023095-4dannjjm 4429 14 bladders bladder NNS cord-023095-4dannjjm 4429 15 compared compare VBN cord-023095-4dannjjm 4429 16 to to IN cord-023095-4dannjjm 4429 17 desmoplakin desmoplakin NNP cord-023095-4dannjjm 4429 18 I1II i1ii DT cord-023095-4dannjjm 4429 19 expression expression NN cord-023095-4dannjjm 4429 20 , , , cord-023095-4dannjjm 4429 21 a a DT cord-023095-4dannjjm 4429 22 marker marker NN cord-023095-4dannjjm 4429 23 of of IN cord-023095-4dannjjm 4429 24 urothelial urothelial JJ cord-023095-4dannjjm 4429 25 differentiation differentiation NN cord-023095-4dannjjm 4429 26 . . . cord-023095-4dannjjm 4430 1 Urinary urinary JJ cord-023095-4dannjjm 4430 2 bladder bladder NN cord-023095-4dannjjm 4430 3 biopsy biopsy NN cord-023095-4dannjjm 4430 4 specimens specimen NNS cord-023095-4dannjjm 4430 5 were be VBD cord-023095-4dannjjm 4430 6 obtained obtain VBN cord-023095-4dannjjm 4430 7 by by IN cord-023095-4dannjjm 4430 8 cystotomy cystotomy NN cord-023095-4dannjjm 4430 9 from from IN cord-023095-4dannjjm 4430 10 9 9 CD cord-023095-4dannjjm 4430 11 symptomatic symptomatic JJ cord-023095-4dannjjm 4430 12 cats cat NNS cord-023095-4dannjjm 4430 13 with with IN cord-023095-4dannjjm 4430 14 chronic chronic JJ cord-023095-4dannjjm 4430 15 FIC fic NN cord-023095-4dannjjm 4430 16 . . . cord-023095-4dannjjm 4431 1 Cats cat NNS cord-023095-4dannjjm 4431 2 with with IN cord-023095-4dannjjm 4431 3 a a DT cord-023095-4dannjjm 4431 4 history history NN cord-023095-4dannjjm 4431 5 of of IN cord-023095-4dannjjm 4431 6 another another DT cord-023095-4dannjjm 4431 7 major major JJ cord-023095-4dannjjm 4431 8 disease disease NN cord-023095-4dannjjm 4431 9 , , , cord-023095-4dannjjm 4431 10 previous previous JJ cord-023095-4dannjjm 4431 11 cystotomy cystotomy NN cord-023095-4dannjjm 4431 12 , , , cord-023095-4dannjjm 4431 13 or or CC cord-023095-4dannjjm 4431 14 recent recent JJ cord-023095-4dannjjm 4431 15 treatment treatment NN cord-023095-4dannjjm 4431 16 with with IN cord-023095-4dannjjm 4431 17 corticosteroids corticosteroid NNS cord-023095-4dannjjm 4431 18 , , , cord-023095-4dannjjm 4431 19 NSAIDs nsaid NNS cord-023095-4dannjjm 4431 20 , , , cord-023095-4dannjjm 4431 21 antihistamines antihistamine NNS cord-023095-4dannjjm 4431 22 , , , cord-023095-4dannjjm 4431 23 antidepressants antidepressant NNS cord-023095-4dannjjm 4431 24 , , , cord-023095-4dannjjm 4431 25 or or CC cord-023095-4dannjjm 4431 26 glycosaminoglycans glycosaminoglycan NNS cord-023095-4dannjjm 4431 27 were be VBD cord-023095-4dannjjm 4431 28 excluded exclude VBN cord-023095-4dannjjm 4431 29 . . . cord-023095-4dannjjm 4432 1 Urinary urinary JJ cord-023095-4dannjjm 4432 2 bladder bladder NN cord-023095-4dannjjm 4432 3 tissue tissue NN cord-023095-4dannjjm 4432 4 specimens specimen NNS cord-023095-4dannjjm 4432 5 were be VBD cord-023095-4dannjjm 4432 6 also also RB cord-023095-4dannjjm 4432 7 obtained obtain VBN cord-023095-4dannjjm 4432 8 from from IN cord-023095-4dannjjm 4432 9 10 10 CD cord-023095-4dannjjm 4432 10 untreated untreated JJ cord-023095-4dannjjm 4432 11 clinically clinically RB cord-023095-4dannjjm 4432 12 normal normal JJ cord-023095-4dannjjm 4432 13 specific specific JJ cord-023095-4dannjjm 4432 14 - - HYPH cord-023095-4dannjjm 4432 15 pathogen pathogen NN cord-023095-4dannjjm 4432 16 - - HYPH cord-023095-4dannjjm 4432 17 free free JJ cord-023095-4dannjjm 4432 18 cats cat NNS cord-023095-4dannjjm 4432 19 . . . cord-023095-4dannjjm 4433 1 Tissue tissue NN cord-023095-4dannjjm 4433 2 specimens specimen NNS cord-023095-4dannjjm 4433 3 were be VBD cord-023095-4dannjjm 4433 4 fixed fix VBN cord-023095-4dannjjm 4433 5 in in IN cord-023095-4dannjjm 4433 6 buffered buffer VBN cord-023095-4dannjjm 4433 7 10 10 CD cord-023095-4dannjjm 4433 8 % % NN cord-023095-4dannjjm 4433 9 formalin formalin NN cord-023095-4dannjjm 4433 10 and and CC cord-023095-4dannjjm 4433 11 embedded embed VBN cord-023095-4dannjjm 4433 12 in in IN cord-023095-4dannjjm 4433 13 paraffin paraffin NN cord-023095-4dannjjm 4433 14 . . . cord-023095-4dannjjm 4434 1 Tissue tissue NN cord-023095-4dannjjm 4434 2 sections section NNS cord-023095-4dannjjm 4434 3 were be VBD cord-023095-4dannjjm 4434 4 deparaffinized deparaffinize VBN cord-023095-4dannjjm 4434 5 and and CC cord-023095-4dannjjm 4434 6 subjected subject VBN cord-023095-4dannjjm 4434 7 to to IN cord-023095-4dannjjm 4434 8 citrate citrate NNP cord-023095-4dannjjm 4434 9 buffer buffer NNP cord-023095-4dannjjm 4434 10 microwave microwave NNP cord-023095-4dannjjm 4434 11 antigen antigen NNP cord-023095-4dannjjm 4434 12 retrieval retrieval NNP cord-023095-4dannjjm 4434 13 . . . cord-023095-4dannjjm 4435 1 Tissues tissue NNS cord-023095-4dannjjm 4435 2 were be VBD cord-023095-4dannjjm 4435 3 stained stain VBN cord-023095-4dannjjm 4435 4 for for IN cord-023095-4dannjjm 4435 5 PGDH PGDH NNS cord-023095-4dannjjm 4435 6 using use VBG cord-023095-4dannjjm 4435 7 a a DT cord-023095-4dannjjm 4435 8 rabbit rabbit NN cord-023095-4dannjjm 4435 9 anti anti JJ cord-023095-4dannjjm 4435 10 - - JJ cord-023095-4dannjjm 4435 11 PGDH PGDH NNP cord-023095-4dannjjm 4435 12 antibody antibody NN cord-023095-4dannjjm 4435 13 , , , cord-023095-4dannjjm 4435 14 an an DT cord-023095-4dannjjm 4435 15 isotype isotype JJ cord-023095-4dannjjm 4435 16 negative negative JJ cord-023095-4dannjjm 4435 17 control control NN cord-023095-4dannjjm 4435 18 or or CC cord-023095-4dannjjm 4435 19 goat goat NN cord-023095-4dannjjm 4435 20 anti anti NNP cord-023095-4dannjjm 4435 21 - - JJ cord-023095-4dannjjm 4435 22 desmoplakin desmoplakin JJ cord-023095-4dannjjm 4435 23 I1II i1ii CD cord-023095-4dannjjm 4435 24 and and CC cord-023095-4dannjjm 4435 25 developed develop VBD cord-023095-4dannjjm 4435 26 using use VBG cord-023095-4dannjjm 4435 27 the the DT cord-023095-4dannjjm 4435 28 avidin avidin NN cord-023095-4dannjjm 4435 29 - - HYPH cord-023095-4dannjjm 4435 30 biotin biotin NN cord-023095-4dannjjm 4435 31 peroxidase peroxidase NN cord-023095-4dannjjm 4435 32 complex complex JJ cord-023095-4dannjjm 4435 33 method method NN cord-023095-4dannjjm 4435 34 . . . cord-023095-4dannjjm 4436 1 All all DT cord-023095-4dannjjm 4436 2 FIC fic NN cord-023095-4dannjjm 4436 3 ( ( -LRB- cord-023095-4dannjjm 4436 4 9/9 9/9 CD cord-023095-4dannjjm 4436 5 ) ) -RRB- cord-023095-4dannjjm 4436 6 and and CC cord-023095-4dannjjm 4436 7 normal normal JJ cord-023095-4dannjjm 4436 8 ( ( -LRB- cord-023095-4dannjjm 4436 9 10/10 10/10 CD cord-023095-4dannjjm 4436 10 ) ) -RRB- cord-023095-4dannjjm 4436 11 cat cat NN cord-023095-4dannjjm 4436 12 bladder bladder NN cord-023095-4dannjjm 4436 13 samples sample NNS cord-023095-4dannjjm 4436 14 showed show VBD cord-023095-4dannjjm 4436 15 similar similar JJ cord-023095-4dannjjm 4436 16 staining staining NN cord-023095-4dannjjm 4436 17 of of IN cord-023095-4dannjjm 4436 18 urothelial urothelial JJ cord-023095-4dannjjm 4436 19 cytoplasm cytoplasm NN cord-023095-4dannjjm 4436 20 for for IN cord-023095-4dannjjm 4436 21 PGDH PGDH NNS cord-023095-4dannjjm 4436 22 . . . cord-023095-4dannjjm 4437 1 However however RB cord-023095-4dannjjm 4437 2 , , , cord-023095-4dannjjm 4437 3 desmoplakin desmoplakin NNP cord-023095-4dannjjm 4437 4 I1II i1ii RB cord-023095-4dannjjm 4437 5 staining stain VBG cord-023095-4dannjjm 4437 6 , , , cord-023095-4dannjjm 4437 7 found find VBN cord-023095-4dannjjm 4437 8 on on IN cord-023095-4dannjjm 4437 9 the the DT cord-023095-4dannjjm 4437 10 luminal luminal JJ cord-023095-4dannjjm 4437 11 cell cell NN cord-023095-4dannjjm 4437 12 surface surface NN cord-023095-4dannjjm 4437 13 in in IN cord-023095-4dannjjm 4437 14 4/4 4/4 CD cord-023095-4dannjjm 4437 15 normal normal JJ cord-023095-4dannjjm 4437 16 tissues tissue NNS cord-023095-4dannjjm 4437 17 , , , cord-023095-4dannjjm 4437 18 was be VBD cord-023095-4dannjjm 4437 19 disrupted disrupt VBN cord-023095-4dannjjm 4437 20 in in IN cord-023095-4dannjjm 4437 21 6/6 6/6 CD cord-023095-4dannjjm 4437 22 FIC fic NN cord-023095-4dannjjm 4437 23 bladder bladder NN cord-023095-4dannjjm 4437 24 samples sample NNS cord-023095-4dannjjm 4437 25 . . . cord-023095-4dannjjm 4438 1 Desmoplakin Desmoplakin NNP cord-023095-4dannjjm 4438 2 I1II i1ii XX cord-023095-4dannjjm 4439 1 staining stain VBG cord-023095-4dannjjm 4439 2 confirmed confirm VBD cord-023095-4dannjjm 4439 3 altered alter VBN cord-023095-4dannjjm 4439 4 urothelial urothelial JJ cord-023095-4dannjjm 4439 5 differentiation differentiation NN cord-023095-4dannjjm 4439 6 in in IN cord-023095-4dannjjm 4439 7 FIC fic NN cord-023095-4dannjjm 4439 8 cats cat NNS cord-023095-4dannjjm 4439 9 . . . cord-023095-4dannjjm 4440 1 However however RB cord-023095-4dannjjm 4440 2 , , , cord-023095-4dannjjm 4440 3 PGDH PGDH NNP cord-023095-4dannjjm 4440 4 expression expression NN cord-023095-4dannjjm 4440 5 remained remain VBD cord-023095-4dannjjm 4440 6 intact intact JJ cord-023095-4dannjjm 4440 7 in in IN cord-023095-4dannjjm 4440 8 FIC fic NN cord-023095-4dannjjm 4440 9 samples sample NNS cord-023095-4dannjjm 4440 10 . . . cord-023095-4dannjjm 4441 1 We -PRON- PRP cord-023095-4dannjjm 4441 2 hypothesize hypothesize VBP cord-023095-4dannjjm 4441 3 that that IN cord-023095-4dannjjm 4441 4 PGDH PGDH NNP cord-023095-4dannjjm 4441 5 expression expression NN cord-023095-4dannjjm 4441 6 in in IN cord-023095-4dannjjm 4441 7 FIC FIC NNP cord-023095-4dannjjm 4441 8 may may MD cord-023095-4dannjjm 4441 9 contribute contribute VB cord-023095-4dannjjm 4441 10 to to IN cord-023095-4dannjjm 4441 11 its -PRON- PRP$ cord-023095-4dannjjm 4441 12 pathophysiology pathophysiology NN cord-023095-4dannjjm 4441 13 due due IN cord-023095-4dannjjm 4441 14 to to IN cord-023095-4dannjjm 4441 15 breakdown breakdown NN cord-023095-4dannjjm 4441 16 of of IN cord-023095-4dannjjm 4441 17 prostaglandins prostaglandin NNS cord-023095-4dannjjm 4441 18 essential essential JJ cord-023095-4dannjjm 4441 19 for for IN cord-023095-4dannjjm 4441 20 urothelial urothelial JJ cord-023095-4dannjjm 4441 21 healing healing NN cord-023095-4dannjjm 4441 22 . . . cord-023095-4dannjjm 4442 1 Additional additional JJ cord-023095-4dannjjm 4442 2 studies study NNS cord-023095-4dannjjm 4442 3 will will MD cord-023095-4dannjjm 4442 4 explore explore VB cord-023095-4dannjjm 4442 5 this this DT cord-023095-4dannjjm 4442 6 hypothesis hypothesis NN cord-023095-4dannjjm 4442 7 . . . cord-023095-4dannjjm 4443 1 The the DT cord-023095-4dannjjm 4443 2 University University NNP cord-023095-4dannjjm 4443 3 of of IN cord-023095-4dannjjm 4443 4 Tennessee Tennessee NNP cord-023095-4dannjjm 4443 5 College College NNP cord-023095-4dannjjm 4443 6 Of of IN cord-023095-4dannjjm 4443 7 Veterinary Veterinary NNP cord-023095-4dannjjm 4443 8 Medicine Medicine NNP cord-023095-4dannjjm 4443 9 's 's POS cord-023095-4dannjjm 4443 10 Picture Picture NNP cord-023095-4dannjjm 4443 11 Archiving Archiving NNP cord-023095-4dannjjm 4443 12 and and CC cord-023095-4dannjjm 4443 13 Communication Communication NNP cord-023095-4dannjjm 4443 14 System System NNP cord-023095-4dannjjm 4443 15 was be VBD cord-023095-4dannjjm 4443 16 searched search VBN cord-023095-4dannjjm 4443 17 over over IN cord-023095-4dannjjm 4443 18 a a DT cord-023095-4dannjjm 4443 19 9 9 CD cord-023095-4dannjjm 4443 20 month month NN cord-023095-4dannjjm 4443 21 period period NN cord-023095-4dannjjm 4443 22 for for IN cord-023095-4dannjjm 4443 23 cats cat NNS cord-023095-4dannjjm 4443 24 that that WDT cord-023095-4dannjjm 4443 25 had have VBD cord-023095-4dannjjm 4443 26 undergone undergo VBN cord-023095-4dannjjm 4443 27 both both DT cord-023095-4dannjjm 4443 28 abdominal abdominal JJ cord-023095-4dannjjm 4443 29 radiographs radiograph NNS cord-023095-4dannjjm 4443 30 and and CC cord-023095-4dannjjm 4443 31 ultrasound ultrasound NN cord-023095-4dannjjm 4443 32 during during IN cord-023095-4dannjjm 4443 33 the the DT cord-023095-4dannjjm 4443 34 same same JJ cord-023095-4dannjjm 4443 35 visit visit NN cord-023095-4dannjjm 4443 36 . . . cord-023095-4dannjjm 4444 1 One one CD cord-023095-4dannjjm 4444 2 hundred hundred CD cord-023095-4dannjjm 4444 3 and and CC cord-023095-4dannjjm 4444 4 three three CD cord-023095-4dannjjm 4444 5 cats cat NNS cord-023095-4dannjjm 4444 6 were be VBD cord-023095-4dannjjm 4444 7 identified identify VBN cord-023095-4dannjjm 4444 8 ( ( -LRB- cord-023095-4dannjjm 4444 9 age age NN cord-023095-4dannjjm 4444 10 range range NN cord-023095-4dannjjm 4444 11 o o NN cord-023095-4dannjjm 4444 12 1 1 CD cord-023095-4dannjjm 4444 13 to to IN cord-023095-4dannjjm 4444 14 18yrs 18yrs JJ cord-023095-4dannjjm 4444 15 ; ; : cord-023095-4dannjjm 4444 16 median median JJ cord-023095-4dannjjm 4444 17 11yrs 11yr NNS cord-023095-4dannjjm 4444 18 ) ) -RRB- cord-023095-4dannjjm 4444 19 . . . cord-023095-4dannjjm 4445 1 Kidney kidney NN cord-023095-4dannjjm 4445 2 size size NN cord-023095-4dannjjm 4445 3 was be VBD cord-023095-4dannjjm 4445 4 determined determine VBN cord-023095-4dannjjm 4445 5 based base VBN cord-023095-4dannjjm 4445 6 on on IN cord-023095-4dannjjm 4445 7 radiographic radiographic JJ cord-023095-4dannjjm 4445 8 and and CC cord-023095-4dannjjm 4445 9 ultrasound ultrasound NN cord-023095-4dannjjm 4445 10 findings finding NNS cord-023095-4dannjjm 4445 11 . . . cord-023095-4dannjjm 4446 1 Of of IN cord-023095-4dannjjm 4446 2 the the DT cord-023095-4dannjjm 4446 3 included include VBN cord-023095-4dannjjm 4446 4 cats cat NNS cord-023095-4dannjjm 4446 5 , , , cord-023095-4dannjjm 4446 6 41.8 41.8 CD cord-023095-4dannjjm 4446 7 % % NN cord-023095-4dannjjm 4446 8 had have VBD cord-023095-4dannjjm 4446 9 two two CD cord-023095-4dannjjm 4446 10 normal normal JJ cord-023095-4dannjjm 4446 11 sized sized JJ cord-023095-4dannjjm 4446 12 kidneys kidney NNS cord-023095-4dannjjm 4446 13 , , , cord-023095-4dannjjm 4446 14 18.4 18.4 CD cord-023095-4dannjjm 4446 15 % % NN cord-023095-4dannjjm 4446 16 had have VBD cord-023095-4dannjjm 4446 17 one one CD cord-023095-4dannjjm 4446 18 small small JJ cord-023095-4dannjjm 4446 19 and and CC cord-023095-4dannjjm 4446 20 one one CD cord-023095-4dannjjm 4446 21 normal normal JJ cord-023095-4dannjjm 4446 22 , , , cord-023095-4dannjjm 4446 23 15.5 15.5 CD cord-023095-4dannjjm 4446 24 % % NN cord-023095-4dannjjm 4446 25 had have VBD cord-023095-4dannjjm 4446 26 one one CD cord-023095-4dannjjm 4446 27 large large JJ cord-023095-4dannjjm 4446 28 and and CC cord-023095-4dannjjm 4446 29 one one CD cord-023095-4dannjjm 4446 30 normal normal JJ cord-023095-4dannjjm 4446 31 , , , cord-023095-4dannjjm 4446 32 11.7 11.7 CD cord-023095-4dannjjm 4446 33 % % NN cord-023095-4dannjjm 4446 34 had have VBD cord-023095-4dannjjm 4446 35 two two CD cord-023095-4dannjjm 4446 36 small small JJ cord-023095-4dannjjm 4446 37 , , , cord-023095-4dannjjm 4446 38 8.7 8.7 CD cord-023095-4dannjjm 4446 39 % % NN cord-023095-4dannjjm 4446 40 had have VBD cord-023095-4dannjjm 4446 41 two two CD cord-023095-4dannjjm 4446 42 large large JJ cord-023095-4dannjjm 4446 43 , , , cord-023095-4dannjjm 4446 44 and and CC cord-023095-4dannjjm 4446 45 3.9 3.9 CD cord-023095-4dannjjm 4446 46 % % NN cord-023095-4dannjjm 4446 47 had have VBD cord-023095-4dannjjm 4446 48 one one CD cord-023095-4dannjjm 4446 49 small small JJ cord-023095-4dannjjm 4446 50 and and CC cord-023095-4dannjjm 4446 51 one one CD cord-023095-4dannjjm 4446 52 large large JJ cord-023095-4dannjjm 4446 53 kidney kidney NN cord-023095-4dannjjm 4446 54 . . . cord-023095-4dannjjm 4447 1 The the DT cord-023095-4dannjjm 4447 2 presence presence NN cord-023095-4dannjjm 4447 3 of of IN cord-023095-4dannjjm 4447 4 mineralization mineralization NN cord-023095-4dannjjm 4447 5 , , , cord-023095-4dannjjm 4447 6 uroliths urolith NNS cord-023095-4dannjjm 4447 7 and and CC cord-023095-4dannjjm 4447 8 hydronephrosis hydronephrosis NN cord-023095-4dannjjm 4447 9 was be VBD cord-023095-4dannjjm 4447 10 also also RB cord-023095-4dannjjm 4447 11 noted note VBN cord-023095-4dannjjm 4447 12 . . . cord-023095-4dannjjm 4448 1 Medical medical JJ cord-023095-4dannjjm 4448 2 records record NNS cord-023095-4dannjjm 4448 3 were be VBD cord-023095-4dannjjm 4448 4 reviewed review VBN cord-023095-4dannjjm 4448 5 for for IN cord-023095-4dannjjm 4448 6 clinical clinical JJ cord-023095-4dannjjm 4448 7 chemistry chemistry NN cord-023095-4dannjjm 4448 8 data datum NNS cord-023095-4dannjjm 4448 9 and and CC cord-023095-4dannjjm 4448 10 historical historical JJ cord-023095-4dannjjm 4448 11 information information NN cord-023095-4dannjjm 4448 12 concerning concern VBG cord-023095-4dannjjm 4448 13 previous previous JJ cord-023095-4dannjjm 4448 14 urinary urinary JJ cord-023095-4dannjjm 4448 15 disease disease NN cord-023095-4dannjjm 4448 16 . . . cord-023095-4dannjjm 4449 1 No no DT cord-023095-4dannjjm 4449 2 significant significant JJ cord-023095-4dannjjm 4449 3 differences difference NNS cord-023095-4dannjjm 4449 4 were be VBD cord-023095-4dannjjm 4449 5 found find VBN cord-023095-4dannjjm 4449 6 between between IN cord-023095-4dannjjm 4449 7 kidney kidney NN cord-023095-4dannjjm 4449 8 size size NN cord-023095-4dannjjm 4449 9 and and CC cord-023095-4dannjjm 4449 10 renal renal JJ cord-023095-4dannjjm 4449 11 function function NN cord-023095-4dannjjm 4449 12 , , , cord-023095-4dannjjm 4449 13 kidney kidney NN cord-023095-4dannjjm 4449 14 size size NN cord-023095-4dannjjm 4449 15 and and CC cord-023095-4dannjjm 4449 16 the the DT cord-023095-4dannjjm 4449 17 presence presence NN cord-023095-4dannjjm 4449 18 of of IN cord-023095-4dannjjm 4449 19 uroliths uroliths NNP cord-023095-4dannjjm 4449 20 , , , cord-023095-4dannjjm 4449 21 renal renal JJ cord-023095-4dannjjm 4449 22 mineralization mineralization NN cord-023095-4dannjjm 4449 23 and and CC cord-023095-4dannjjm 4449 24 function function NN cord-023095-4dannjjm 4449 25 or or CC cord-023095-4dannjjm 4449 26 the the DT cord-023095-4dannjjm 4449 27 presence presence NN cord-023095-4dannjjm 4449 28 of of IN cord-023095-4dannjjm 4449 29 uroliths uroliths NNP cord-023095-4dannjjm 4449 30 and and CC cord-023095-4dannjjm 4449 31 function function NN cord-023095-4dannjjm 4449 32 . . . cord-023095-4dannjjm 4450 1 The the DT cord-023095-4dannjjm 4450 2 presence presence NN cord-023095-4dannjjm 4450 3 of of IN cord-023095-4dannjjm 4450 4 uroliths uroliths NNP cord-023095-4dannjjm 4450 5 was be VBD cord-023095-4dannjjm 4450 6 significantly significantly RB cord-023095-4dannjjm 4450 7 associated associate VBN cord-023095-4dannjjm 4450 8 with with IN cord-023095-4dannjjm 4450 9 hydronephrosis hydronephrosis NN cord-023095-4dannjjm 4450 10 . . . cord-023095-4dannjjm 4451 1 Of of IN cord-023095-4dannjjm 4451 2 the the DT cord-023095-4dannjjm 4451 3 30 30 CD cord-023095-4dannjjm 4451 4 cats cat NNS cord-023095-4dannjjm 4451 5 with with IN cord-023095-4dannjjm 4451 6 at at RB cord-023095-4dannjjm 4451 7 least least RBS cord-023095-4dannjjm 4451 8 one one CD cord-023095-4dannjjm 4451 9 large large JJ cord-023095-4dannjjm 4451 10 kidney kidney NN cord-023095-4dannjjm 4451 11 , , , cord-023095-4dannjjm 4451 12 9 9 CD cord-023095-4dannjjm 4451 13 ( ( -LRB- cord-023095-4dannjjm 4451 14 30 30 CD cord-023095-4dannjjm 4451 15 % % NN cord-023095-4dannjjm 4451 16 ) ) -RRB- cord-023095-4dannjjm 4451 17 had have VBD cord-023095-4dannjjm 4451 18 hydronephrosis hydronephrosis NN cord-023095-4dannjjm 4451 19 . . . cord-023095-4dannjjm 4452 1 Of of IN cord-023095-4dannjjm 4452 2 the the DT cord-023095-4dannjjm 4452 3 23 23 CD cord-023095-4dannjjm 4452 4 cats cat NNS cord-023095-4dannjjm 4452 5 with with IN cord-023095-4dannjjm 4452 6 current current JJ cord-023095-4dannjjm 4452 7 or or CC cord-023095-4dannjjm 4452 8 previously previously RB cord-023095-4dannjjm 4452 9 diagnosed diagnose VBN cord-023095-4dannjjm 4452 10 uroliths urolith NNS cord-023095-4dannjjm 4452 11 , , , cord-023095-4dannjjm 4452 12 urinary urinary JJ cord-023095-4dannjjm 4452 13 tract tract NN cord-023095-4dannjjm 4452 14 infections infection NNS cord-023095-4dannjjm 4452 15 or or CC cord-023095-4dannjjm 4452 16 other other JJ cord-023095-4dannjjm 4452 17 uropathies uropathy NNS cord-023095-4dannjjm 4452 18 , , , cord-023095-4dannjjm 4452 19 10 10 CD cord-023095-4dannjjm 4452 20 ( ( -LRB- cord-023095-4dannjjm 4452 21 43.5 43.5 CD cord-023095-4dannjjm 4452 22 % % NN cord-023095-4dannjjm 4452 23 ) ) -RRB- cord-023095-4dannjjm 4452 24 had have VBD cord-023095-4dannjjm 4452 25 at at RB cord-023095-4dannjjm 4452 26 least least RBS cord-023095-4dannjjm 4452 27 one one CD cord-023095-4dannjjm 4452 28 small small JJ cord-023095-4dannjjm 4452 29 kidney kidney NN cord-023095-4dannjjm 4452 30 . . . cord-023095-4dannjjm 4453 1 Small small JJ cord-023095-4dannjjm 4453 2 kidneys kidney NNS cord-023095-4dannjjm 4453 3 were be VBD cord-023095-4dannjjm 4453 4 commonly commonly RB cord-023095-4dannjjm 4453 5 found find VBN cord-023095-4dannjjm 4453 6 in in IN cord-023095-4dannjjm 4453 7 older old JJR cord-023095-4dannjjm 4453 8 cats cat NNS cord-023095-4dannjjm 4453 9 , , , cord-023095-4dannjjm 4453 10 however however RB cord-023095-4dannjjm 4453 11 , , , cord-023095-4dannjjm 4453 12 this this DT cord-023095-4dannjjm 4453 13 correlation correlation NN cord-023095-4dannjjm 4453 14 was be VBD cord-023095-4dannjjm 4453 15 not not RB cord-023095-4dannjjm 4453 16 statistically statistically RB cord-023095-4dannjjm 4453 17 significant significant JJ cord-023095-4dannjjm 4453 18 . . . cord-023095-4dannjjm 4454 1 Based base VBN cord-023095-4dannjjm 4454 2 on on IN cord-023095-4dannjjm 4454 3 these these DT cord-023095-4dannjjm 4454 4 findings finding NNS cord-023095-4dannjjm 4454 5 , , , cord-023095-4dannjjm 4454 6 small small JJ cord-023095-4dannjjm 4454 7 kidneys kidney NNS cord-023095-4dannjjm 4454 8 are be VBP cord-023095-4dannjjm 4454 9 more more RBR cord-023095-4dannjjm 4454 10 likely likely JJ cord-023095-4dannjjm 4454 11 to to TO cord-023095-4dannjjm 4454 12 be be VB cord-023095-4dannjjm 4454 13 the the DT cord-023095-4dannjjm 4454 14 result result NN cord-023095-4dannjjm 4454 15 of of IN cord-023095-4dannjjm 4454 16 urinary urinary JJ cord-023095-4dannjjm 4454 17 disease disease NN cord-023095-4dannjjm 4454 18 as as IN cord-023095-4dannjjm 4454 19 opposed oppose VBN cord-023095-4dannjjm 4454 20 to to IN cord-023095-4dannjjm 4454 21 being be VBG cord-023095-4dannjjm 4454 22 either either CC cord-023095-4dannjjm 4454 23 congenital congenital JJ cord-023095-4dannjjm 4454 24 or or CC cord-023095-4dannjjm 4454 25 due due JJ cord-023095-4dannjjm 4454 26 to to IN cord-023095-4dannjjm 4454 27 aging age VBG cord-023095-4dannjjm 4454 28 . . . cord-023095-4dannjjm 4455 1 This this DT cord-023095-4dannjjm 4455 2 study study NN cord-023095-4dannjjm 4455 3 aimed aim VBD cord-023095-4dannjjm 4455 4 to to TO cord-023095-4dannjjm 4455 5 evaluate evaluate VB cord-023095-4dannjjm 4455 6 IFE IFE NNP cord-023095-4dannjjm 4455 7 , , , cord-023095-4dannjjm 4455 8 which which WDT cord-023095-4dannjjm 4455 9 has have VBZ cord-023095-4dannjjm 4455 10 been be VBN cord-023095-4dannjjm 4455 11 advocated advocate VBN cord-023095-4dannjjm 4455 12 for for IN cord-023095-4dannjjm 4455 13 treatment treatment NN cord-023095-4dannjjm 4455 14 of of IN cord-023095-4dannjjm 4455 15 lipid lipid NN cord-023095-4dannjjm 4455 16 - - HYPH cord-023095-4dannjjm 4455 17 soluble soluble JJ cord-023095-4dannjjm 4455 18 drug drug NN cord-023095-4dannjjm 4455 19 intoxication intoxication NN cord-023095-4dannjjm 4455 20 , , , cord-023095-4dannjjm 4455 21 in in IN cord-023095-4dannjjm 4455 22 the the DT cord-023095-4dannjjm 4455 23 treatment treatment NN cord-023095-4dannjjm 4455 24 of of IN cord-023095-4dannjjm 4455 25 clinically clinically RB cord-023095-4dannjjm 4455 26 - - HYPH cord-023095-4dannjjm 4455 27 occurring occur VBG cord-023095-4dannjjm 4455 28 canine canine JJ cord-023095-4dannjjm 4455 29 ivermectin ivermectin NN cord-023095-4dannjjm 4455 30 toxicosis toxicosis NN cord-023095-4dannjjm 4455 31 . . . cord-023095-4dannjjm 4456 1 One one CD cord-023095-4dannjjm 4456 2 Australian australian JJ cord-023095-4dannjjm 4456 3 Shepherd Shepherd NNP cord-023095-4dannjjm 4456 4 and and CC cord-023095-4dannjjm 4456 5 two two CD cord-023095-4dannjjm 4456 6 Miniature miniature JJ cord-023095-4dannjjm 4456 7 Australian australian JJ cord-023095-4dannjjm 4456 8 Shepherds Shepherds NNPS cord-023095-4dannjjm 4456 9 were be VBD cord-023095-4dannjjm 4456 10 included include VBN cord-023095-4dannjjm 4456 11 . . . cord-023095-4dannjjm 4457 1 All all DT cord-023095-4dannjjm 4457 2 three three CD cord-023095-4dannjjm 4457 3 dogs dog NNS cord-023095-4dannjjm 4457 4 were be VBD cord-023095-4dannjjm 4457 5 homozygous homozygous JJ cord-023095-4dannjjm 4457 6 for for IN cord-023095-4dannjjm 4457 7 the the DT cord-023095-4dannjjm 4457 8 MDR-1 MDR-1 NNP cord-023095-4dannjjm 4457 9 gene gene NN cord-023095-4dannjjm 4457 10 mutation mutation NN cord-023095-4dannjjm 4457 11 . . . cord-023095-4dannjjm 4458 1 Two two CD cord-023095-4dannjjm 4458 2 dogs dog NNS cord-023095-4dannjjm 4458 3 roamed roam VBD cord-023095-4dannjjm 4458 4 on on IN cord-023095-4dannjjm 4458 5 horse horse NN cord-023095-4dannjjm 4458 6 ranches ranch NNS cord-023095-4dannjjm 4458 7 where where WRB cord-023095-4dannjjm 4458 8 ivermectin ivermectin NN cord-023095-4dannjjm 4458 9 - - HYPH cord-023095-4dannjjm 4458 10 based base VBN cord-023095-4dannjjm 4458 11 deworming deworme VBG cord-023095-4dannjjm 4458 12 products product NNS cord-023095-4dannjjm 4458 13 had have VBD cord-023095-4dannjjm 4458 14 recently recently RB cord-023095-4dannjjm 4458 15 been be VBN cord-023095-4dannjjm 4458 16 used use VBN cord-023095-4dannjjm 4458 17 . . . cord-023095-4dannjjm 4459 1 Ivermectin Ivermectin NNP cord-023095-4dannjjm 4459 2 was be VBD cord-023095-4dannjjm 4459 3 administered administer VBN cord-023095-4dannjjm 4459 4 to to IN cord-023095-4dannjjm 4459 5 the the DT cord-023095-4dannjjm 4459 6 third third JJ cord-023095-4dannjjm 4459 7 dog dog NN cord-023095-4dannjjm 4459 8 ( ( -LRB- cord-023095-4dannjjm 4459 9 165 165 CD cord-023095-4dannjjm 4459 10 mg mg NNP cord-023095-4dannjjm 4459 11 / / SYM cord-023095-4dannjjm 4459 12 kg kg NNP cord-023095-4dannjjm 4459 13 PO PO NNP cord-023095-4dannjjm 4459 14 ) ) -RRB- cord-023095-4dannjjm 4459 15 . . . cord-023095-4dannjjm 4460 1 All all DT cord-023095-4dannjjm 4460 2 three three CD cord-023095-4dannjjm 4460 3 dogs dog NNS cord-023095-4dannjjm 4460 4 exhibited exhibit VBD cord-023095-4dannjjm 4460 5 tremors tremor NNS cord-023095-4dannjjm 4460 6 , , , cord-023095-4dannjjm 4460 7 ptyalism ptyalism NN cord-023095-4dannjjm 4460 8 , , , cord-023095-4dannjjm 4460 9 and and CC cord-023095-4dannjjm 4460 10 CNS CNS NNP cord-023095-4dannjjm 4460 11 depression depression NN cord-023095-4dannjjm 4460 12 , , , cord-023095-4dannjjm 4460 13 which which WDT cord-023095-4dannjjm 4460 14 progressed progress VBD cord-023095-4dannjjm 4460 15 over over IN cord-023095-4dannjjm 4460 16 several several JJ cord-023095-4dannjjm 4460 17 hours hour NNS cord-023095-4dannjjm 4460 18 to to TO cord-023095-4dannjjm 4460 19 stupor stupor NN cord-023095-4dannjjm 4460 20 in in IN cord-023095-4dannjjm 4460 21 two two CD cord-023095-4dannjjm 4460 22 dogs dog NNS cord-023095-4dannjjm 4460 23 , , , cord-023095-4dannjjm 4460 24 and and CC cord-023095-4dannjjm 4460 25 to to IN cord-023095-4dannjjm 4460 26 a a DT cord-023095-4dannjjm 4460 27 comatose comatose JJ cord-023095-4dannjjm 4460 28 state state NN cord-023095-4dannjjm 4460 29 requiring require VBG cord-023095-4dannjjm 4460 30 mechanical mechanical JJ cord-023095-4dannjjm 4460 31 ventilation ventilation NN cord-023095-4dannjjm 4460 32 in in IN cord-023095-4dannjjm 4460 33 the the DT cord-023095-4dannjjm 4460 34 remaining remain VBG cord-023095-4dannjjm 4460 35 dog dog NN cord-023095-4dannjjm 4460 36 . . . cord-023095-4dannjjm 4461 1 A a DT cord-023095-4dannjjm 4461 2 20 20 CD cord-023095-4dannjjm 4461 3 % % NN cord-023095-4dannjjm 4461 4 formulation formulation NN cord-023095-4dannjjm 4461 5 of of IN cord-023095-4dannjjm 4461 6 IFE IFE NNP cord-023095-4dannjjm 4461 7 ( ( -LRB- cord-023095-4dannjjm 4461 8 Liposyn Liposyn NNP cord-023095-4dannjjm 4461 9 II II NNP cord-023095-4dannjjm 4461 10 , , , cord-023095-4dannjjm 4461 11 Hospira Hospira NNP cord-023095-4dannjjm 4461 12 ) ) -RRB- cord-023095-4dannjjm 4461 13 was be VBD cord-023095-4dannjjm 4461 14 administered administer VBN cord-023095-4dannjjm 4461 15 as as IN cord-023095-4dannjjm 4461 16 a a DT cord-023095-4dannjjm 4461 17 bolus bolus NN cord-023095-4dannjjm 4461 18 ( ( -LRB- cord-023095-4dannjjm 4461 19 1.5 1.5 CD cord-023095-4dannjjm 4461 20 ml ml NNS cord-023095-4dannjjm 4461 21 / / SYM cord-023095-4dannjjm 4461 22 kg kg NN cord-023095-4dannjjm 4461 23 ) ) -RRB- cord-023095-4dannjjm 4461 24 followed follow VBN cord-023095-4dannjjm 4461 25 by by IN cord-023095-4dannjjm 4461 26 a a DT cord-023095-4dannjjm 4461 27 slow slow JJ cord-023095-4dannjjm 4461 28 IV IV NNP cord-023095-4dannjjm 4461 29 infusion infusion NN cord-023095-4dannjjm 4461 30 ( ( -LRB- cord-023095-4dannjjm 4461 31 7.5 7.5 CD cord-023095-4dannjjm 4461 32 - - SYM cord-023095-4dannjjm 4461 33 15 15 CD cord-023095-4dannjjm 4461 34 ml ml NN cord-023095-4dannjjm 4461 35 / / SYM cord-023095-4dannjjm 4461 36 kg kg NN cord-023095-4dannjjm 4461 37 over over IN cord-023095-4dannjjm 4461 38 30 30 CD cord-023095-4dannjjm 4461 39 minutes minute NNS cord-023095-4dannjjm 4461 40 ) ) -RRB- cord-023095-4dannjjm 4461 41 . . . cord-023095-4dannjjm 4462 1 No no DT cord-023095-4dannjjm 4462 2 change change NN cord-023095-4dannjjm 4462 3 was be VBD cord-023095-4dannjjm 4462 4 observed observe VBN cord-023095-4dannjjm 4462 5 in in IN cord-023095-4dannjjm 4462 6 the the DT cord-023095-4dannjjm 4462 7 neurologic neurologic JJ cord-023095-4dannjjm 4462 8 status status NN cord-023095-4dannjjm 4462 9 of of IN cord-023095-4dannjjm 4462 10 any any DT cord-023095-4dannjjm 4462 11 patient patient NN cord-023095-4dannjjm 4462 12 . . . cord-023095-4dannjjm 4463 1 Lipemia lipemia NN cord-023095-4dannjjm 4463 2 visible visible JJ cord-023095-4dannjjm 4463 3 upon upon IN cord-023095-4dannjjm 4463 4 blood blood NN cord-023095-4dannjjm 4463 5 sampling sampling NN cord-023095-4dannjjm 4463 6 persisted persist VBD cord-023095-4dannjjm 4463 7 for for IN cord-023095-4dannjjm 4463 8 36 36 CD cord-023095-4dannjjm 4463 9 hours hour NNS cord-023095-4dannjjm 4463 10 in in IN cord-023095-4dannjjm 4463 11 one one CD cord-023095-4dannjjm 4463 12 dog dog NN cord-023095-4dannjjm 4463 13 . . . cord-023095-4dannjjm 4464 1 No no DT cord-023095-4dannjjm 4464 2 other other JJ cord-023095-4dannjjm 4464 3 adverse adverse JJ cord-023095-4dannjjm 4464 4 effects effect NNS cord-023095-4dannjjm 4464 5 were be VBD cord-023095-4dannjjm 4464 6 noted note VBN cord-023095-4dannjjm 4464 7 . . . cord-023095-4dannjjm 4465 1 Serum serum NN cord-023095-4dannjjm 4465 2 ivermectin ivermectin NNP cord-023095-4dannjjm 4465 3 levels level NNS cord-023095-4dannjjm 4465 4 confirmed confirm VBD cord-023095-4dannjjm 4465 5 ivermectin ivermectin NNP cord-023095-4dannjjm 4465 6 exposure exposure NN cord-023095-4dannjjm 4465 7 in in IN cord-023095-4dannjjm 4465 8 each each DT cord-023095-4dannjjm 4465 9 case case NN cord-023095-4dannjjm 4465 10 . . . cord-023095-4dannjjm 4466 1 In in IN cord-023095-4dannjjm 4466 2 this this DT cord-023095-4dannjjm 4466 3 study study NN cord-023095-4dannjjm 4466 4 , , , cord-023095-4dannjjm 4466 5 IFE IFE NNP cord-023095-4dannjjm 4466 6 administration administration NN cord-023095-4dannjjm 4466 7 did do VBD cord-023095-4dannjjm 4466 8 not not RB cord-023095-4dannjjm 4466 9 result result VB cord-023095-4dannjjm 4466 10 in in IN cord-023095-4dannjjm 4466 11 clinical clinical JJ cord-023095-4dannjjm 4466 12 benefit benefit NN cord-023095-4dannjjm 4466 13 in in IN cord-023095-4dannjjm 4466 14 cases case NNS cord-023095-4dannjjm 4466 15 of of IN cord-023095-4dannjjm 4466 16 ivermectin ivermectin NNP cord-023095-4dannjjm 4466 17 toxicosis toxicosis NN cord-023095-4dannjjm 4466 18 . . . cord-023095-4dannjjm 4467 1 Brain Brain NNP cord-023095-4dannjjm 4467 2 ivermectin ivermectin NNP cord-023095-4dannjjm 4467 3 concentrations concentration NNS cord-023095-4dannjjm 4467 4 in in IN cord-023095-4dannjjm 4467 5 MDR1 MDR1 NNP cord-023095-4dannjjm 4467 6 mutant mutant JJ cord-023095-4dannjjm 4467 7 / / SYM cord-023095-4dannjjm 4467 8 mutant mutant JJ cord-023095-4dannjjm 4467 9 genotype genotype NN cord-023095-4dannjjm 4467 10 dogs dog NNS cord-023095-4dannjjm 4467 11 may may MD cord-023095-4dannjjm 4467 12 be be VB cord-023095-4dannjjm 4467 13 too too RB cord-023095-4dannjjm 4467 14 high high JJ cord-023095-4dannjjm 4467 15 to to TO cord-023095-4dannjjm 4467 16 be be VB cord-023095-4dannjjm 4467 17 overcome overcome VBN cord-023095-4dannjjm 4467 18 by by IN cord-023095-4dannjjm 4467 19 IFE IFE NNP cord-023095-4dannjjm 4467 20 . . . cord-023095-4dannjjm 4468 1 Additionally additionally RB cord-023095-4dannjjm 4468 2 , , , cord-023095-4dannjjm 4468 3 these these DT cord-023095-4dannjjm 4468 4 dogs dog NNS cord-023095-4dannjjm 4468 5 may may MD cord-023095-4dannjjm 4468 6 lack lack VB cord-023095-4dannjjm 4468 7 P p NN cord-023095-4dannjjm 4468 8 - - HYPH cord-023095-4dannjjm 4468 9 glycoprotein glycoprotein NN cord-023095-4dannjjm 4468 10 - - HYPH cord-023095-4dannjjm 4468 11 mediated mediate VBN cord-023095-4dannjjm 4468 12 biliary biliary JJ cord-023095-4dannjjm 4468 13 clearance clearance NN cord-023095-4dannjjm 4468 14 mechanisms mechanism NNS cord-023095-4dannjjm 4468 15 needed need VBN cord-023095-4dannjjm 4468 16 for for IN cord-023095-4dannjjm 4468 17 optimal optimal JJ cord-023095-4dannjjm 4468 18 IFE IFE NNP cord-023095-4dannjjm 4468 19 function function NN cord-023095-4dannjjm 4468 20 . . . cord-023095-4dannjjm 4469 1 Further further JJ cord-023095-4dannjjm 4469 2 investigation investigation NN cord-023095-4dannjjm 4469 3 is be VBZ cord-023095-4dannjjm 4469 4 needed need VBN cord-023095-4dannjjm 4469 5 to to TO cord-023095-4dannjjm 4469 6 determine determine VB cord-023095-4dannjjm 4469 7 the the DT cord-023095-4dannjjm 4469 8 utility utility NN cord-023095-4dannjjm 4469 9 and and CC cord-023095-4dannjjm 4469 10 optimal optimal JJ cord-023095-4dannjjm 4469 11 dosing dosing NN cord-023095-4dannjjm 4469 12 of of IN cord-023095-4dannjjm 4469 13 IFE IFE NNP cord-023095-4dannjjm 4469 14 in in IN cord-023095-4dannjjm 4469 15 canine canine JJ cord-023095-4dannjjm 4469 16 toxicoses toxicose NNS cord-023095-4dannjjm 4469 17 , , , cord-023095-4dannjjm 4469 18 to to TO cord-023095-4dannjjm 4469 19 characterize characterize VB cord-023095-4dannjjm 4469 20 its -PRON- PRP$ cord-023095-4dannjjm 4469 21 safety safety NN cord-023095-4dannjjm 4469 22 , , , cord-023095-4dannjjm 4469 23 and and CC cord-023095-4dannjjm 4469 24 to to TO cord-023095-4dannjjm 4469 25 determine determine VB cord-023095-4dannjjm 4469 26 how how WRB cord-023095-4dannjjm 4469 27 MDR-1 MDR-1 NNP cord-023095-4dannjjm 4469 28 status status NN cord-023095-4dannjjm 4469 29 may may MD cord-023095-4dannjjm 4469 30 alter alter VB cord-023095-4dannjjm 4469 31 the the DT cord-023095-4dannjjm 4469 32 efficacy efficacy NN cord-023095-4dannjjm 4469 33 of of IN cord-023095-4dannjjm 4469 34 IFE IFE NNP cord-023095-4dannjjm 4469 35 in in IN cord-023095-4dannjjm 4469 36 treatment treatment NN cord-023095-4dannjjm 4469 37 of of IN cord-023095-4dannjjm 4469 38 canine canine JJ cord-023095-4dannjjm 4469 39 ivermectin ivermectin NNP cord-023095-4dannjjm 4469 40 intoxication intoxication NN cord-023095-4dannjjm 4469 41 . . . cord-023095-4dannjjm 4470 1 Rufinamide Rufinamide NNP cord-023095-4dannjjm 4470 2 is be VBZ cord-023095-4dannjjm 4470 3 a a DT cord-023095-4dannjjm 4470 4 recently recently RB cord-023095-4dannjjm 4470 5 approved approve VBN cord-023095-4dannjjm 4470 6 antiepileptic antiepileptic JJ cord-023095-4dannjjm 4470 7 drug drug NN cord-023095-4dannjjm 4470 8 used use VBN cord-023095-4dannjjm 4470 9 for for IN cord-023095-4dannjjm 4470 10 the the DT cord-023095-4dannjjm 4470 11 treatment treatment NN cord-023095-4dannjjm 4470 12 of of IN cord-023095-4dannjjm 4470 13 seizure seizure NN cord-023095-4dannjjm 4470 14 disorders disorder NNS cord-023095-4dannjjm 4470 15 in in IN cord-023095-4dannjjm 4470 16 human human JJ cord-023095-4dannjjm 4470 17 patients patient NNS cord-023095-4dannjjm 4470 18 . . . cord-023095-4dannjjm 4471 1 Rufinamide Rufinamide NNP cord-023095-4dannjjm 4471 2 is be VBZ cord-023095-4dannjjm 4471 3 administered administer VBN cord-023095-4dannjjm 4471 4 at at IN cord-023095-4dannjjm 4471 5 a a DT cord-023095-4dannjjm 4471 6 dose dose NN cord-023095-4dannjjm 4471 7 of of IN cord-023095-4dannjjm 4471 8 45 45 CD cord-023095-4dannjjm 4471 9 mg mg NNP cord-023095-4dannjjm 4471 10 / / SYM cord-023095-4dannjjm 4471 11 kg kg NNS cord-023095-4dannjjm 4471 12 divided divide VBD cord-023095-4dannjjm 4471 13 twice twice RB cord-023095-4dannjjm 4471 14 daily daily RB cord-023095-4dannjjm 4471 15 to to TO cord-023095-4dannjjm 4471 16 achieve achieve VB cord-023095-4dannjjm 4471 17 therapeutic therapeutic JJ cord-023095-4dannjjm 4471 18 concentrations concentration NNS cord-023095-4dannjjm 4471 19 of of IN cord-023095-4dannjjm 4471 20 15 15 CD cord-023095-4dannjjm 4471 21 mg mg NNP cord-023095-4dannjjm 4471 22 / / SYM cord-023095-4dannjjm 4471 23 ml ml NN cord-023095-4dannjjm 4471 24 . . . cord-023095-4dannjjm 4472 1 The the DT cord-023095-4dannjjm 4472 2 objective objective NN cord-023095-4dannjjm 4472 3 of of IN cord-023095-4dannjjm 4472 4 this this DT cord-023095-4dannjjm 4472 5 study study NN cord-023095-4dannjjm 4472 6 was be VBD cord-023095-4dannjjm 4472 7 to to TO cord-023095-4dannjjm 4472 8 determine determine VB cord-023095-4dannjjm 4472 9 the the DT cord-023095-4dannjjm 4472 10 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 4472 11 properties property NNS cord-023095-4dannjjm 4472 12 and and CC cord-023095-4dannjjm 4472 13 short short JJ cord-023095-4dannjjm 4472 14 - - HYPH cord-023095-4dannjjm 4472 15 term term NN cord-023095-4dannjjm 4472 16 adverse adverse JJ cord-023095-4dannjjm 4472 17 effects effect NNS cord-023095-4dannjjm 4472 18 of of IN cord-023095-4dannjjm 4472 19 single single JJ cord-023095-4dannjjm 4472 20 - - HYPH cord-023095-4dannjjm 4472 21 dose dose NN cord-023095-4dannjjm 4472 22 oral oral JJ cord-023095-4dannjjm 4472 23 rufinamide rufinamide NN cord-023095-4dannjjm 4472 24 in in IN cord-023095-4dannjjm 4472 25 healthy healthy JJ cord-023095-4dannjjm 4472 26 dogs dog NNS cord-023095-4dannjjm 4472 27 in in IN cord-023095-4dannjjm 4472 28 preparation preparation NN cord-023095-4dannjjm 4472 29 for for IN cord-023095-4dannjjm 4472 30 a a DT cord-023095-4dannjjm 4472 31 possible possible JJ cord-023095-4dannjjm 4472 32 clinical clinical JJ cord-023095-4dannjjm 4472 33 trial trial NN cord-023095-4dannjjm 4472 34 evaluating evaluate VBG cord-023095-4dannjjm 4472 35 the the DT cord-023095-4dannjjm 4472 36 efficacy efficacy NN cord-023095-4dannjjm 4472 37 of of IN cord-023095-4dannjjm 4472 38 rufinamide rufinamide NN cord-023095-4dannjjm 4472 39 in in IN cord-023095-4dannjjm 4472 40 the the DT cord-023095-4dannjjm 4472 41 treatment treatment NN cord-023095-4dannjjm 4472 42 of of IN cord-023095-4dannjjm 4472 43 canine canine JJ cord-023095-4dannjjm 4472 44 epilepsy epilepsy NN cord-023095-4dannjjm 4472 45 . . . cord-023095-4dannjjm 4473 1 Six six CD cord-023095-4dannjjm 4473 2 healthy healthy JJ cord-023095-4dannjjm 4473 3 adult adult NN cord-023095-4dannjjm 4473 4 dogs dog NNS cord-023095-4dannjjm 4473 5 were be VBD cord-023095-4dannjjm 4473 6 included include VBN cord-023095-4dannjjm 4473 7 . . . cord-023095-4dannjjm 4474 1 The the DT cord-023095-4dannjjm 4474 2 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 4474 3 of of IN cord-023095-4dannjjm 4474 4 rufinamide rufinamide NNP cord-023095-4dannjjm 4474 5 were be VBD cord-023095-4dannjjm 4474 6 calculated calculate VBN cord-023095-4dannjjm 4474 7 following follow VBG cord-023095-4dannjjm 4474 8 administration administration NN cord-023095-4dannjjm 4474 9 of of IN cord-023095-4dannjjm 4474 10 a a DT cord-023095-4dannjjm 4474 11 single single JJ cord-023095-4dannjjm 4474 12 mean mean NN cord-023095-4dannjjm 4474 13 oral oral JJ cord-023095-4dannjjm 4474 14 dose dose NN cord-023095-4dannjjm 4474 15 of of IN cord-023095-4dannjjm 4474 16 20.0 20.0 CD cord-023095-4dannjjm 4474 17 mg mg NNP cord-023095-4dannjjm 4474 18 / / SYM cord-023095-4dannjjm 4474 19 kg kg NNP cord-023095-4dannjjm 4474 20 ( ( -LRB- cord-023095-4dannjjm 4474 21 range range NNP cord-023095-4dannjjm 4474 22 18.6 18.6 CD cord-023095-4dannjjm 4474 23 - - HYPH cord-023095-4dannjjm 4474 24 20.8 20.8 CD cord-023095-4dannjjm 4474 25 mg mg NNP cord-023095-4dannjjm 4474 26 / / SYM cord-023095-4dannjjm 4474 27 kg kg NNP cord-023095-4dannjjm 4474 28 ) ) -RRB- cord-023095-4dannjjm 4474 29 , , , cord-023095-4dannjjm 4474 30 extrapolated extrapolate VBN cord-023095-4dannjjm 4474 31 from from IN cord-023095-4dannjjm 4474 32 the the DT cord-023095-4dannjjm 4474 33 dose dose NN cord-023095-4dannjjm 4474 34 used use VBN cord-023095-4dannjjm 4474 35 in in IN cord-023095-4dannjjm 4474 36 human human JJ cord-023095-4dannjjm 4474 37 patients patient NNS cord-023095-4dannjjm 4474 38 . . . cord-023095-4dannjjm 4475 1 Dogs dog NNS cord-023095-4dannjjm 4475 2 were be VBD cord-023095-4dannjjm 4475 3 monitored monitor VBN cord-023095-4dannjjm 4475 4 by by IN cord-023095-4dannjjm 4475 5 repeat repeat NN cord-023095-4dannjjm 4475 6 physical physical JJ cord-023095-4dannjjm 4475 7 examinations examination NNS cord-023095-4dannjjm 4475 8 , , , cord-023095-4dannjjm 4475 9 electrocardiograms electrocardiogram NNS cord-023095-4dannjjm 4475 10 and and CC cord-023095-4dannjjm 4475 11 blood blood NN cord-023095-4dannjjm 4475 12 pressure pressure NN cord-023095-4dannjjm 4475 13 assessments assessment NNS cord-023095-4dannjjm 4475 14 during during IN cord-023095-4dannjjm 4475 15 the the DT cord-023095-4dannjjm 4475 16 course course NN cord-023095-4dannjjm 4475 17 of of IN cord-023095-4dannjjm 4475 18 the the DT cord-023095-4dannjjm 4475 19 study study NN cord-023095-4dannjjm 4475 20 . . . cord-023095-4dannjjm 4476 1 Plasma plasma NN cord-023095-4dannjjm 4476 2 rufinamide rufinamide NN cord-023095-4dannjjm 4476 3 concentrations concentration NNS cord-023095-4dannjjm 4476 4 were be VBD cord-023095-4dannjjm 4476 5 determined determine VBN cord-023095-4dannjjm 4476 6 using use VBG cord-023095-4dannjjm 4476 7 high high JJ cord-023095-4dannjjm 4476 8 - - HYPH cord-023095-4dannjjm 4476 9 performance performance NN cord-023095-4dannjjm 4476 10 liquid liquid NN cord-023095-4dannjjm 4476 11 chromatography chromatography NN cord-023095-4dannjjm 4476 12 . . . cord-023095-4dannjjm 4477 1 Pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 4477 2 data datum NNS cord-023095-4dannjjm 4477 3 were be VBD cord-023095-4dannjjm 4477 4 analyzed analyze VBN cord-023095-4dannjjm 4477 5 using use VBG cord-023095-4dannjjm 4477 6 WinNonlin WinNonlin NNP cord-023095-4dannjjm 4477 7 version version NN cord-023095-4dannjjm 4477 8 1.0 1.0 CD cord-023095-4dannjjm 4477 9 . . . cord-023095-4dannjjm 4478 1 No no DT cord-023095-4dannjjm 4478 2 adverse adverse JJ cord-023095-4dannjjm 4478 3 effects effect NNS cord-023095-4dannjjm 4478 4 were be VBD cord-023095-4dannjjm 4478 5 observed observe VBN cord-023095-4dannjjm 4478 6 . . . cord-023095-4dannjjm 4479 1 The the DT cord-023095-4dannjjm 4479 2 mean mean JJ cord-023095-4dannjjm 4479 3 terminal terminal JJ cord-023095-4dannjjm 4479 4 half half JJ cord-023095-4dannjjm 4479 5 - - HYPH cord-023095-4dannjjm 4479 6 life life NN cord-023095-4dannjjm 4479 7 was be VBD cord-023095-4dannjjm 4479 8 9.86 9.86 CD cord-023095-4dannjjm 4479 9 1 1 CD cord-023095-4dannjjm 4479 10 / / SYM cord-023095-4dannjjm 4479 11 À à NN cord-023095-4dannjjm 4479 12 4.77 4.77 CD cord-023095-4dannjjm 4479 13 hours hour NNS cord-023095-4dannjjm 4479 14 . . . cord-023095-4dannjjm 4480 1 The the DT cord-023095-4dannjjm 4480 2 mean mean JJ cord-023095-4dannjjm 4480 3 maximum maximum JJ cord-023095-4dannjjm 4480 4 plasma plasma NN cord-023095-4dannjjm 4480 5 concentration concentration NN cord-023095-4dannjjm 4480 6 was be VBD cord-023095-4dannjjm 4480 7 19.561/ 19.561/ CD cord-023095-4dannjjm 4481 1 À5.82 À5.82 NNP cord-023095-4dannjjm 4482 1 mg mg NNP cord-023095-4dannjjm 4482 2 / / SYM cord-023095-4dannjjm 4482 3 ml ml NNP cord-023095-4dannjjm 4482 4 and and CC cord-023095-4dannjjm 4482 5 the the DT cord-023095-4dannjjm 4482 6 mean mean JJ cord-023095-4dannjjm 4482 7 time time NN cord-023095-4dannjjm 4482 8 to to TO cord-023095-4dannjjm 4482 9 maximum maximum VB cord-023095-4dannjjm 4482 10 plasma plasma NN cord-023095-4dannjjm 4482 11 concentration concentration NN cord-023095-4dannjjm 4482 12 was be VBD cord-023095-4dannjjm 4482 13 9.33 9.33 CD cord-023095-4dannjjm 4482 14 1 1 CD cord-023095-4dannjjm 4482 15 / / SYM cord-023095-4dannjjm 4482 16 À à NN cord-023095-4dannjjm 4482 17 4.68 4.68 CD cord-023095-4dannjjm 4482 18 hours hour NNS cord-023095-4dannjjm 4482 19 . . . cord-023095-4dannjjm 4483 1 Mean mean JJ cord-023095-4dannjjm 4483 2 clearance clearance NN cord-023095-4dannjjm 4483 3 was be VBD cord-023095-4dannjjm 4483 4 1.448 1.448 CD cord-023095-4dannjjm 4483 5 1 1 CD cord-023095-4dannjjm 4483 6 / / SYM cord-023095-4dannjjm 4483 7 À à NN cord-023095-4dannjjm 4483 8 0.703 0.703 CD cord-023095-4dannjjm 4483 9 L l NN cord-023095-4dannjjm 4483 10 / / SYM cord-023095-4dannjjm 4483 11 hr hr NN cord-023095-4dannjjm 4483 12 . . . cord-023095-4dannjjm 4484 1 AUC AUC NNP cord-023095-4dannjjm 4484 2 inf inf NNP cord-023095-4dannjjm 4484 3 was be VBD cord-023095-4dannjjm 4484 4 410.72 410.72 CD cord-023095-4dannjjm 4484 5 1 1 CD cord-023095-4dannjjm 4484 6 / / SYM cord-023095-4dannjjm 4484 7 À à NN cord-023095-4dannjjm 4484 8 175.88 175.88 CD cord-023095-4dannjjm 4484 9 mgÃh mgãh NN cord-023095-4dannjjm 4484 10 / / SYM cord-023095-4dannjjm 4484 11 ml ml NN cord-023095-4dannjjm 4484 12 . . . cord-023095-4dannjjm 4485 1 Results result NNS cord-023095-4dannjjm 4485 2 of of IN cord-023095-4dannjjm 4485 3 this this DT cord-023095-4dannjjm 4485 4 study study NN cord-023095-4dannjjm 4485 5 suggest suggest VBP cord-023095-4dannjjm 4485 6 that that IN cord-023095-4dannjjm 4485 7 rufinamide rufinamide NN cord-023095-4dannjjm 4485 8 given give VBN cord-023095-4dannjjm 4485 9 orally orally RB cord-023095-4dannjjm 4485 10 at at IN cord-023095-4dannjjm 4485 11 20 20 CD cord-023095-4dannjjm 4485 12 mg/ mg/ NN cord-023095-4dannjjm 4485 13 kg kg NNP cord-023095-4dannjjm 4485 14 twice twice RB cord-023095-4dannjjm 4485 15 daily daily RB cord-023095-4dannjjm 4485 16 in in IN cord-023095-4dannjjm 4485 17 healthy healthy JJ cord-023095-4dannjjm 4485 18 dogs dog NNS cord-023095-4dannjjm 4485 19 should should MD cord-023095-4dannjjm 4485 20 result result VB cord-023095-4dannjjm 4485 21 in in IN cord-023095-4dannjjm 4485 22 a a DT cord-023095-4dannjjm 4485 23 plasma plasma NN cord-023095-4dannjjm 4485 24 concentration concentration NN cord-023095-4dannjjm 4485 25 and and CC cord-023095-4dannjjm 4485 26 half half JJ cord-023095-4dannjjm 4485 27 - - HYPH cord-023095-4dannjjm 4485 28 life life NN cord-023095-4dannjjm 4485 29 sufficient sufficient JJ cord-023095-4dannjjm 4485 30 to to TO cord-023095-4dannjjm 4485 31 achieve achieve VB cord-023095-4dannjjm 4485 32 the the DT cord-023095-4dannjjm 4485 33 therapeutic therapeutic JJ cord-023095-4dannjjm 4485 34 level level NN cord-023095-4dannjjm 4485 35 extrapolated extrapolate VBN cord-023095-4dannjjm 4485 36 from from IN cord-023095-4dannjjm 4485 37 humans human NNS cord-023095-4dannjjm 4485 38 without without IN cord-023095-4dannjjm 4485 39 short short JJ cord-023095-4dannjjm 4485 40 - - HYPH cord-023095-4dannjjm 4485 41 term term NN cord-023095-4dannjjm 4485 42 adverse adverse JJ cord-023095-4dannjjm 4485 43 effects effect NNS cord-023095-4dannjjm 4485 44 . . . cord-023095-4dannjjm 4486 1 Further further JJ cord-023095-4dannjjm 4486 2 investigation investigation NN cord-023095-4dannjjm 4486 3 into into IN cord-023095-4dannjjm 4486 4 the the DT cord-023095-4dannjjm 4486 5 efficacy efficacy NN cord-023095-4dannjjm 4486 6 and and CC cord-023095-4dannjjm 4486 7 long long JJ cord-023095-4dannjjm 4486 8 - - HYPH cord-023095-4dannjjm 4486 9 term term NN cord-023095-4dannjjm 4486 10 safety safety NN cord-023095-4dannjjm 4486 11 of of IN cord-023095-4dannjjm 4486 12 rufinamide rufinamide NN cord-023095-4dannjjm 4486 13 in in IN cord-023095-4dannjjm 4486 14 the the DT cord-023095-4dannjjm 4486 15 treatment treatment NN cord-023095-4dannjjm 4486 16 of of IN cord-023095-4dannjjm 4486 17 canine canine JJ cord-023095-4dannjjm 4486 18 epilepsy epilepsy NN cord-023095-4dannjjm 4486 19 is be VBZ cord-023095-4dannjjm 4486 20 warranted warrant VBN cord-023095-4dannjjm 4486 21 . . . cord-023095-4dannjjm 4487 1 The the DT cord-023095-4dannjjm 4487 2 aims aim NNS cord-023095-4dannjjm 4487 3 of of IN cord-023095-4dannjjm 4487 4 this this DT cord-023095-4dannjjm 4487 5 study study NN cord-023095-4dannjjm 4487 6 were be VBD cord-023095-4dannjjm 4487 7 to to TO cord-023095-4dannjjm 4487 8 investigate investigate VB cord-023095-4dannjjm 4487 9 the the DT cord-023095-4dannjjm 4487 10 ABG ABG NNP cord-023095-4dannjjm 4487 11 for for IN cord-023095-4dannjjm 4487 12 ( ( -LRB- cord-023095-4dannjjm 4487 13 i i NN cord-023095-4dannjjm 4487 14 ) ) -RRB- cord-023095-4dannjjm 4488 1 the the DT cord-023095-4dannjjm 4488 2 prevalence prevalence NN cord-023095-4dannjjm 4488 3 of of IN cord-023095-4dannjjm 4488 4 skull skull NN cord-023095-4dannjjm 4488 5 abnormalities abnormality NNS cord-023095-4dannjjm 4488 6 ; ; , cord-023095-4dannjjm 4488 7 ( ( -LRB- cord-023095-4dannjjm 4488 8 ii ii NN cord-023095-4dannjjm 4488 9 ) ) -RRB- cord-023095-4dannjjm 4489 1 the the DT cord-023095-4dannjjm 4489 2 prevalence prevalence NN cord-023095-4dannjjm 4489 3 of of IN cord-023095-4dannjjm 4489 4 SM sm NN cord-023095-4dannjjm 4489 5 ; ; : cord-023095-4dannjjm 4489 6 ( ( -LRB- cord-023095-4dannjjm 4489 7 iii iii NN cord-023095-4dannjjm 4489 8 ) ) -RRB- cord-023095-4dannjjm 4490 1 an an DT cord-023095-4dannjjm 4490 2 association association NN cord-023095-4dannjjm 4490 3 between between IN cord-023095-4dannjjm 4490 4 lateral lateral JJ cord-023095-4dannjjm 4490 5 ventricular ventricular JJ cord-023095-4dannjjm 4490 6 size size NN cord-023095-4dannjjm 4490 7 , , , cord-023095-4dannjjm 4490 8 cerebellar cerebellar JJ cord-023095-4dannjjm 4490 9 size size NN cord-023095-4dannjjm 4490 10 and and CC cord-023095-4dannjjm 4490 11 SM sm NN cord-023095-4dannjjm 4490 12 ; ; : cord-023095-4dannjjm 4490 13 and and CC cord-023095-4dannjjm 4490 14 ( ( -LRB- cord-023095-4dannjjm 4490 15 iv iv LS cord-023095-4dannjjm 4490 16 ) ) -RRB- cord-023095-4dannjjm 4490 17 associations association NNS cord-023095-4dannjjm 4490 18 between between IN cord-023095-4dannjjm 4490 19 SM sm NN cord-023095-4dannjjm 4490 20 , , , cord-023095-4dannjjm 4490 21 skull skull NN cord-023095-4dannjjm 4490 22 abnormalities abnormality NNS cord-023095-4dannjjm 4490 23 , , , cord-023095-4dannjjm 4490 24 CSF CSF NNP cord-023095-4dannjjm 4490 25 pleocytosis pleocytosis NNP cord-023095-4dannjjm 4490 26 and and CC cord-023095-4dannjjm 4490 27 clinical clinical JJ cord-023095-4dannjjm 4490 28 signs sign NNS cord-023095-4dannjjm 4490 29 . . . cord-023095-4dannjjm 4491 1 Seventy seventy CD cord-023095-4dannjjm 4491 2 - - HYPH cord-023095-4dannjjm 4491 3 six six CD cord-023095-4dannjjm 4491 4 ABGs abg NNS cord-023095-4dannjjm 4491 5 , , , cord-023095-4dannjjm 4491 6 recruited recruit VBN cord-023095-4dannjjm 4491 7 as as IN cord-023095-4dannjjm 4491 8 part part NN cord-023095-4dannjjm 4491 9 of of IN cord-023095-4dannjjm 4491 10 a a DT cord-023095-4dannjjm 4491 11 larger large JJR cord-023095-4dannjjm 4491 12 epidemiological epidemiological JJ cord-023095-4dannjjm 4491 13 and and CC cord-023095-4dannjjm 4491 14 genetic genetic JJ cord-023095-4dannjjm 4491 15 study study NN cord-023095-4dannjjm 4491 16 , , , cord-023095-4dannjjm 4491 17 underwent undergo VBD cord-023095-4dannjjm 4491 18 brain brain NN cord-023095-4dannjjm 4491 19 and and CC cord-023095-4dannjjm 4491 20 spinal spinal JJ cord-023095-4dannjjm 4491 21 MRI mri NN cord-023095-4dannjjm 4491 22 evaluation evaluation NN cord-023095-4dannjjm 4491 23 ( ( -LRB- cord-023095-4dannjjm 4491 24 3.0 3.0 CD cord-023095-4dannjjm 4491 25 T T NNP cord-023095-4dannjjm 4491 26 General General NNP cord-023095-4dannjjm 4491 27 Electric Electric NNP cord-023095-4dannjjm 4491 28 Signa Signa NNP cord-023095-4dannjjm 4491 29 HDx HDx NNS cord-023095-4dannjjm 4491 30 , , , cord-023095-4dannjjm 4491 31 Milwaukee Milwaukee NNP cord-023095-4dannjjm 4491 32 , , , cord-023095-4dannjjm 4491 33 WI WI NNP cord-023095-4dannjjm 4491 34 ) ) -RRB- cord-023095-4dannjjm 4491 35 . . . cord-023095-4dannjjm 4492 1 All all DT cord-023095-4dannjjm 4492 2 dogs dog NNS cord-023095-4dannjjm 4492 3 were be VBD cord-023095-4dannjjm 4492 4 evaluated evaluate VBN cord-023095-4dannjjm 4492 5 neurologically neurologically RB cord-023095-4dannjjm 4492 6 , , , cord-023095-4dannjjm 4492 7 recording record VBG cord-023095-4dannjjm 4492 8 deficits deficit NNS cord-023095-4dannjjm 4492 9 and and CC cord-023095-4dannjjm 4492 10 the the DT cord-023095-4dannjjm 4492 11 presence presence NN cord-023095-4dannjjm 4492 12 of of IN cord-023095-4dannjjm 4492 13 spinal spinal JJ cord-023095-4dannjjm 4492 14 pain pain NN cord-023095-4dannjjm 4492 15 . . . cord-023095-4dannjjm 4493 1 Sequences sequence NNS cord-023095-4dannjjm 4493 2 acquired acquire VBD cord-023095-4dannjjm 4493 3 included include VBD cord-023095-4dannjjm 4493 4 T2W T2W NNP cord-023095-4dannjjm 4493 5 , , , cord-023095-4dannjjm 4493 6 T1W T1W NNP cord-023095-4dannjjm 4493 7 pre pre JJ cord-023095-4dannjjm 4493 8 - - JJ cord-023095-4dannjjm 4493 9 and and CC cord-023095-4dannjjm 4493 10 postcontrast postcontrast NN cord-023095-4dannjjm 4493 11 , , , cord-023095-4dannjjm 4493 12 and and CC cord-023095-4dannjjm 4493 13 T2W t2w CD cord-023095-4dannjjm 4493 14 FLAIR flair NN cord-023095-4dannjjm 4493 15 , , , cord-023095-4dannjjm 4493 16 sagittal sagittal JJ cord-023095-4dannjjm 4493 17 and and CC cord-023095-4dannjjm 4493 18 transverse transverse JJ cord-023095-4dannjjm 4493 19 . . . cord-023095-4dannjjm 4494 1 Cervical cervical JJ cord-023095-4dannjjm 4494 2 spinal spinal JJ cord-023095-4dannjjm 4494 3 cord cord NN cord-023095-4dannjjm 4494 4 central central JJ cord-023095-4dannjjm 4494 5 canal canal NNP cord-023095-4dannjjm 4494 6 ( ( -LRB- cord-023095-4dannjjm 4494 7 CC CC NNP cord-023095-4dannjjm 4494 8 ) ) -RRB- cord-023095-4dannjjm 4494 9 and and CC cord-023095-4dannjjm 4494 10 or or CC cord-023095-4dannjjm 4494 11 syrinx syrinx JJ cord-023095-4dannjjm 4494 12 size size NN cord-023095-4dannjjm 4494 13 and and CC cord-023095-4dannjjm 4494 14 its -PRON- PRP$ cord-023095-4dannjjm 4494 15 percent percent NN cord-023095-4dannjjm 4494 16 area area NN cord-023095-4dannjjm 4494 17 of of IN cord-023095-4dannjjm 4494 18 spinal spinal JJ cord-023095-4dannjjm 4494 19 cord cord NN cord-023095-4dannjjm 4494 20 was be VBD cord-023095-4dannjjm 4494 21 measured measure VBN cord-023095-4dannjjm 4494 22 using use VBG cord-023095-4dannjjm 4494 23 OsiriX OsiriX NNP cord-023095-4dannjjm 4494 24 s s NN cord-023095-4dannjjm 4494 25 . . . cord-023095-4dannjjm 4495 1 The the DT cord-023095-4dannjjm 4495 2 presence presence NN cord-023095-4dannjjm 4495 3 of of IN cord-023095-4dannjjm 4495 4 Chari Chari NNP cord-023095-4dannjjm 4495 5 - - HYPH cord-023095-4dannjjm 4495 6 like like JJ cord-023095-4dannjjm 4495 7 malformation malformation NN cord-023095-4dannjjm 4495 8 ( ( -LRB- cord-023095-4dannjjm 4495 9 CM CM NNP cord-023095-4dannjjm 4495 10 ) ) -RRB- cord-023095-4dannjjm 4495 11 was be VBD cord-023095-4dannjjm 4495 12 assessed assess VBN cord-023095-4dannjjm 4495 13 by by IN cord-023095-4dannjjm 4495 14 recording record VBG cord-023095-4dannjjm 4495 15 the the DT cord-023095-4dannjjm 4495 16 presence presence NN cord-023095-4dannjjm 4495 17 of of IN cord-023095-4dannjjm 4495 18 caudal caudal JJ cord-023095-4dannjjm 4495 19 cerebellar cerebellar JJ cord-023095-4dannjjm 4495 20 deviation deviation NN cord-023095-4dannjjm 4495 21 and/or and/or CC cord-023095-4dannjjm 4495 22 foramenal foramenal JJ cord-023095-4dannjjm 4495 23 vermal vermal NNP cord-023095-4dannjjm 4495 24 herniation herniation NN cord-023095-4dannjjm 4495 25 . . . cord-023095-4dannjjm 4496 1 Lateral lateral JJ cord-023095-4dannjjm 4496 2 ventricle ventricle NN cord-023095-4dannjjm 4496 3 and and CC cord-023095-4dannjjm 4496 4 cerebellar cerebellar JJ cord-023095-4dannjjm 4496 5 volume volume NN cord-023095-4dannjjm 4496 6 was be VBD cord-023095-4dannjjm 4496 7 expressed express VBN cord-023095-4dannjjm 4496 8 as as IN cord-023095-4dannjjm 4496 9 a a DT cord-023095-4dannjjm 4496 10 percent percent NN cord-023095-4dannjjm 4496 11 of of IN cord-023095-4dannjjm 4496 12 the the DT cord-023095-4dannjjm 4496 13 cerebrum cerebrum NN cord-023095-4dannjjm 4496 14 and and CC cord-023095-4dannjjm 4496 15 intracranial intracranial JJ cord-023095-4dannjjm 4496 16 volume2qa volume2qa NNP cord-023095-4dannjjm 4496 17 respectively respectively RB cord-023095-4dannjjm 4496 18 . . . cord-023095-4dannjjm 4497 1 Forty forty CD cord-023095-4dannjjm 4497 2 - - HYPH cord-023095-4dannjjm 4497 3 five five CD cord-023095-4dannjjm 4497 4 dogs dog NNS cord-023095-4dannjjm 4497 5 underwent undergo VBD cord-023095-4dannjjm 4497 6 atlanto atlanto NNP cord-023095-4dannjjm 4497 7 - - HYPH cord-023095-4dannjjm 4497 8 occipital occipital JJ cord-023095-4dannjjm 4497 9 cerebrospinal cerebrospinal JJ cord-023095-4dannjjm 4497 10 fluid fluid NN cord-023095-4dannjjm 4497 11 tap tap NN cord-023095-4dannjjm 4497 12 at at IN cord-023095-4dannjjm 4497 13 the the DT cord-023095-4dannjjm 4497 14 time time NN cord-023095-4dannjjm 4497 15 of of IN cord-023095-4dannjjm 4497 16 MRI MRI NNP cord-023095-4dannjjm 4497 17 and and CC cord-023095-4dannjjm 4497 18 the the DT cord-023095-4dannjjm 4497 19 white white JJ cord-023095-4dannjjm 4497 20 blood blood NN cord-023095-4dannjjm 4497 21 cell cell NN cord-023095-4dannjjm 4498 1 ( ( -LRB- cord-023095-4dannjjm 4498 2 WBC WBC NNP cord-023095-4dannjjm 4498 3 ) ) -RRB- cord-023095-4dannjjm 4498 4 count count NN cord-023095-4dannjjm 4498 5 was be VBD cord-023095-4dannjjm 4498 6 recorded record VBN cord-023095-4dannjjm 4498 7 . . . cord-023095-4dannjjm 4499 1 Student student NN cord-023095-4dannjjm 4499 2 's 's POS cord-023095-4dannjjm 4499 3 t t NN cord-023095-4dannjjm 4499 4 - - HYPH cord-023095-4dannjjm 4499 5 tests test NNS cord-023095-4dannjjm 4499 6 were be VBD cord-023095-4dannjjm 4499 7 used use VBN cord-023095-4dannjjm 4499 8 to to TO cord-023095-4dannjjm 4499 9 compare compare VB cord-023095-4dannjjm 4499 10 the the DT cord-023095-4dannjjm 4499 11 measured measure VBN cord-023095-4dannjjm 4499 12 variables variable NNS cord-023095-4dannjjm 4499 13 between between IN cord-023095-4dannjjm 4499 14 groups group NNS cord-023095-4dannjjm 4499 15 with with IN cord-023095-4dannjjm 4499 16 and and CC cord-023095-4dannjjm 4499 17 without without IN cord-023095-4dannjjm 4499 18 skull skull NN cord-023095-4dannjjm 4499 19 abnormalities abnormality NNS cord-023095-4dannjjm 4499 20 , , , cord-023095-4dannjjm 4499 21 spinal spinal JJ cord-023095-4dannjjm 4499 22 pain pain NN cord-023095-4dannjjm 4499 23 and and CC cord-023095-4dannjjm 4499 24 neurological neurological JJ cord-023095-4dannjjm 4499 25 signs sign NNS cord-023095-4dannjjm 4499 26 . . . cord-023095-4dannjjm 4500 1 The the DT cord-023095-4dannjjm 4500 2 mean mean JJ cord-023095-4dannjjm 4500 3 age age NN cord-023095-4dannjjm 4500 4 of of IN cord-023095-4dannjjm 4500 5 the the DT cord-023095-4dannjjm 4500 6 30 30 CD cord-023095-4dannjjm 4500 7 males male NNS cord-023095-4dannjjm 4500 8 ( ( -LRB- cord-023095-4dannjjm 4500 9 24 24 CD cord-023095-4dannjjm 4500 10 intact intact JJ cord-023095-4dannjjm 4500 11 ) ) -RRB- cord-023095-4dannjjm 4500 12 and and CC cord-023095-4dannjjm 4500 13 the the DT cord-023095-4dannjjm 4500 14 46 46 CD cord-023095-4dannjjm 4500 15 females female NNS cord-023095-4dannjjm 4500 16 ( ( -LRB- cord-023095-4dannjjm 4500 17 34 34 CD cord-023095-4dannjjm 4500 18 intact intact JJ cord-023095-4dannjjm 4500 19 ) ) -RRB- cord-023095-4dannjjm 4500 20 was be VBD cord-023095-4dannjjm 4500 21 50.4 50.4 CD cord-023095-4dannjjm 4500 22 months month NNS cord-023095-4dannjjm 4501 1 ( ( -LRB- cord-023095-4dannjjm 4501 2 range range NNP cord-023095-4dannjjm 4501 3 8 8 CD cord-023095-4dannjjm 4501 4 - - SYM cord-023095-4dannjjm 4501 5 135 135 CD cord-023095-4dannjjm 4501 6 ; ; : cord-023095-4dannjjm 4501 7 median median NN cord-023095-4dannjjm 4501 8 44 44 CD cord-023095-4dannjjm 4501 9 months month NNS cord-023095-4dannjjm 4501 10 ) ) -RRB- cord-023095-4dannjjm 4501 11 . . . cord-023095-4dannjjm 4502 1 Neurological neurological JJ cord-023095-4dannjjm 4502 2 deficits deficit NNS cord-023095-4dannjjm 4502 3 and and CC cord-023095-4dannjjm 4502 4 neck neck NN cord-023095-4dannjjm 4502 5 pain pain NN cord-023095-4dannjjm 4502 6 were be VBD cord-023095-4dannjjm 4502 7 noted note VBN cord-023095-4dannjjm 4502 8 in in IN cord-023095-4dannjjm 4502 9 21 21 CD cord-023095-4dannjjm 4502 10 ( ( -LRB- cord-023095-4dannjjm 4502 11 27 27 CD cord-023095-4dannjjm 4502 12 % % NN cord-023095-4dannjjm 4502 13 ) ) -RRB- cord-023095-4dannjjm 4502 14 and and CC cord-023095-4dannjjm 4502 15 15 15 CD cord-023095-4dannjjm 4502 16 ( ( -LRB- cord-023095-4dannjjm 4502 17 19.7 19.7 CD cord-023095-4dannjjm 4502 18 % % NN cord-023095-4dannjjm 4502 19 ) ) -RRB- cord-023095-4dannjjm 4502 20 of of IN cord-023095-4dannjjm 4502 21 dogs dog NNS cord-023095-4dannjjm 4502 22 respectively respectively RB cord-023095-4dannjjm 4502 23 ; ; : cord-023095-4dannjjm 4502 24 5 5 CD cord-023095-4dannjjm 4502 25 dogs dog NNS cord-023095-4dannjjm 4502 26 ( ( -LRB- cord-023095-4dannjjm 4502 27 6.57 6.57 CD cord-023095-4dannjjm 4502 28 % % NN cord-023095-4dannjjm 4502 29 ) ) -RRB- cord-023095-4dannjjm 4502 30 exhibited exhibit VBD cord-023095-4dannjjm 4502 31 both both DT cord-023095-4dannjjm 4502 32 . . . cord-023095-4dannjjm 4503 1 Cerebellar cerebellar JJ cord-023095-4dannjjm 4503 2 deviation deviation NN cord-023095-4dannjjm 4503 3 and and CC cord-023095-4dannjjm 4503 4 vermal vermal NN cord-023095-4dannjjm 4503 5 herniation herniation NN cord-023095-4dannjjm 4503 6 were be VBD cord-023095-4dannjjm 4503 7 present present JJ cord-023095-4dannjjm 4503 8 in in IN cord-023095-4dannjjm 4503 9 37 37 CD cord-023095-4dannjjm 4503 10 ( ( -LRB- cord-023095-4dannjjm 4503 11 48.68 48.68 CD cord-023095-4dannjjm 4503 12 % % NN cord-023095-4dannjjm 4503 13 ) ) -RRB- cord-023095-4dannjjm 4503 14 and and CC cord-023095-4dannjjm 4503 15 46 46 CD cord-023095-4dannjjm 4503 16 ( ( -LRB- cord-023095-4dannjjm 4503 17 60.52 60.52 CD cord-023095-4dannjjm 4503 18 % % NN cord-023095-4dannjjm 4503 19 ) ) -RRB- cord-023095-4dannjjm 4503 20 dogs dog NNS cord-023095-4dannjjm 4503 21 respectively respectively RB cord-023095-4dannjjm 4503 22 ; ; : cord-023095-4dannjjm 4503 23 twenty twenty CD cord-023095-4dannjjm 4503 24 - - HYPH cord-023095-4dannjjm 4503 25 three three CD cord-023095-4dannjjm 4503 26 dogs dog NNS cord-023095-4dannjjm 4503 27 ( ( -LRB- cord-023095-4dannjjm 4503 28 30.26 30.26 CD cord-023095-4dannjjm 4503 29 % % NN cord-023095-4dannjjm 4503 30 ) ) -RRB- cord-023095-4dannjjm 4503 31 had have VBD cord-023095-4dannjjm 4503 32 both both DT cord-023095-4dannjjm 4503 33 . . . cord-023095-4dannjjm 4504 1 Mean mean JJ cord-023095-4dannjjm 4504 2 height height NN cord-023095-4dannjjm 4504 3 of of IN cord-023095-4dannjjm 4504 4 the the DT cord-023095-4dannjjm 4504 5 CC CC NNP cord-023095-4dannjjm 4504 6 was be VBD cord-023095-4dannjjm 4504 7 2.3 2.3 CD cord-023095-4dannjjm 4504 8 mm mm NNS cord-023095-4dannjjm 4504 9 ( ( -LRB- cord-023095-4dannjjm 4504 10 0 0 CD cord-023095-4dannjjm 4504 11 - - : cord-023095-4dannjjm 4504 12 7.2 7.2 CD cord-023095-4dannjjm 4504 13 mm mm NN cord-023095-4dannjjm 4504 14 ) ) -RRB- cord-023095-4dannjjm 4504 15 . . . cord-023095-4dannjjm 4505 1 Forty forty CD cord-023095-4dannjjm 4505 2 ( ( -LRB- cord-023095-4dannjjm 4505 3 52.63 52.63 CD cord-023095-4dannjjm 4505 4 % % NN cord-023095-4dannjjm 4505 5 ) ) -RRB- cord-023095-4dannjjm 4505 6 CCs cc NNS cord-023095-4dannjjm 4505 7 were be VBD cord-023095-4dannjjm 4505 8 greater great JJR cord-023095-4dannjjm 4505 9 than than IN cord-023095-4dannjjm 4505 10 2 2 CD cord-023095-4dannjjm 4505 11 mm mm NNS cord-023095-4dannjjm 4505 12 in in IN cord-023095-4dannjjm 4505 13 height height NN cord-023095-4dannjjm 4505 14 ; ; : cord-023095-4dannjjm 4505 15 the the DT cord-023095-4dannjjm 4505 16 mean mean JJ cord-023095-4dannjjm 4505 17 length length NN cord-023095-4dannjjm 4505 18 of of IN cord-023095-4dannjjm 4505 19 these these DT cord-023095-4dannjjm 4505 20 lesions lesion NNS cord-023095-4dannjjm 4505 21 was be VBD cord-023095-4dannjjm 4505 22 2.03 2.03 CD cord-023095-4dannjjm 4505 23 vertebrae vertebra NNS cord-023095-4dannjjm 4505 24 ( ( -LRB- cord-023095-4dannjjm 4505 25 0.5 0.5 CD cord-023095-4dannjjm 4505 26 - - SYM cord-023095-4dannjjm 4505 27 7 7 CD cord-023095-4dannjjm 4505 28 ) ) -RRB- cord-023095-4dannjjm 4505 29 . . . cord-023095-4dannjjm 4506 1 Mean mean JJ cord-023095-4dannjjm 4506 2 CSF CSF NNP cord-023095-4dannjjm 4506 3 WBC WBC NNP cord-023095-4dannjjm 4506 4 count count NN cord-023095-4dannjjm 4506 5 was be VBD cord-023095-4dannjjm 4506 6 4.97 4.97 CD cord-023095-4dannjjm 4506 7 / / SYM cord-023095-4dannjjm 4506 8 ml ml NN cord-023095-4dannjjm 4506 9 ( ( -LRB- cord-023095-4dannjjm 4506 10 0 0 CD cord-023095-4dannjjm 4506 11 - - SYM cord-023095-4dannjjm 4506 12 39 39 CD cord-023095-4dannjjm 4506 13 ) ) -RRB- cord-023095-4dannjjm 4506 14 . . . cord-023095-4dannjjm 4507 1 Syrinx Syrinx NNP cord-023095-4dannjjm 4507 2 height height NN cord-023095-4dannjjm 4507 3 and and CC cord-023095-4dannjjm 4507 4 extent extent NN cord-023095-4dannjjm 4507 5 were be VBD cord-023095-4dannjjm 4507 6 significantly significantly RB cord-023095-4dannjjm 4507 7 higher high JJR cord-023095-4dannjjm 4507 8 in in IN cord-023095-4dannjjm 4507 9 dogs dog NNS cord-023095-4dannjjm 4507 10 with with IN cord-023095-4dannjjm 4507 11 neurological neurological JJ cord-023095-4dannjjm 4507 12 signs sign NNS cord-023095-4dannjjm 4507 13 ( ( -LRB- cord-023095-4dannjjm 4507 14 size size NN cord-023095-4dannjjm 4507 15 p p NN cord-023095-4dannjjm 4507 16 5 5 CD cord-023095-4dannjjm 4507 17 0.01 0.01 CD cord-023095-4dannjjm 4507 18 ; ; : cord-023095-4dannjjm 4507 19 extent extent NN cord-023095-4dannjjm 4507 20 p p NN cord-023095-4dannjjm 4507 21 5 5 CD cord-023095-4dannjjm 4507 22 0.0004 0.0004 CD cord-023095-4dannjjm 4507 23 ) ) -RRB- cord-023095-4dannjjm 4507 24 . . . cord-023095-4dannjjm 4508 1 There there EX cord-023095-4dannjjm 4508 2 were be VBD cord-023095-4dannjjm 4508 3 no no DT cord-023095-4dannjjm 4508 4 significant significant JJ cord-023095-4dannjjm 4508 5 differences difference NNS cord-023095-4dannjjm 4508 6 in in IN cord-023095-4dannjjm 4508 7 syrinx syrinx NNP cord-023095-4dannjjm 4508 8 sizes size NNS cord-023095-4dannjjm 4508 9 and and CC cord-023095-4dannjjm 4508 10 extent extent NN cord-023095-4dannjjm 4508 11 in in IN cord-023095-4dannjjm 4508 12 dogs dog NNS cord-023095-4dannjjm 4508 13 with with IN cord-023095-4dannjjm 4508 14 or or CC cord-023095-4dannjjm 4508 15 without without IN cord-023095-4dannjjm 4508 16 skull skull NN cord-023095-4dannjjm 4508 17 abnormalities abnormality NNS cord-023095-4dannjjm 4508 18 or or CC cord-023095-4dannjjm 4508 19 spinal spinal JJ cord-023095-4dannjjm 4508 20 pain pain NN cord-023095-4dannjjm 4508 21 . . . cord-023095-4dannjjm 4509 1 There there EX cord-023095-4dannjjm 4509 2 were be VBD cord-023095-4dannjjm 4509 3 no no DT cord-023095-4dannjjm 4509 4 associations association NNS cord-023095-4dannjjm 4509 5 of of IN cord-023095-4dannjjm 4509 6 syrinx syrinx NNP cord-023095-4dannjjm 4509 7 height height NN cord-023095-4dannjjm 4509 8 or or CC cord-023095-4dannjjm 4509 9 extent extent NN cord-023095-4dannjjm 4509 10 with with IN cord-023095-4dannjjm 4509 11 CSF CSF NNP cord-023095-4dannjjm 4509 12 WBC WBC NNP cord-023095-4dannjjm 4509 13 count count NN cord-023095-4dannjjm 4509 14 or or CC cord-023095-4dannjjm 4509 15 age age NN cord-023095-4dannjjm 4509 16 of of IN cord-023095-4dannjjm 4509 17 dog dog NN cord-023095-4dannjjm 4509 18 . . . cord-023095-4dannjjm 4510 1 Intact intact JJ cord-023095-4dannjjm 4510 2 females female NNS cord-023095-4dannjjm 4510 3 had have VBD cord-023095-4dannjjm 4510 4 a a DT cord-023095-4dannjjm 4510 5 significantly significantly RB cord-023095-4dannjjm 4510 6 lower low JJR cord-023095-4dannjjm 4510 7 syrinx syrinx JJ cord-023095-4dannjjm 4510 8 extent extent NN cord-023095-4dannjjm 4510 9 than than IN cord-023095-4dannjjm 4510 10 intact intact JJ cord-023095-4dannjjm 4510 11 males male NNS cord-023095-4dannjjm 4510 12 ( ( -LRB- cord-023095-4dannjjm 4510 13 p p NN cord-023095-4dannjjm 4510 14 5 5 CD cord-023095-4dannjjm 4510 15 0.009 0.009 CD cord-023095-4dannjjm 4510 16 ) ) -RRB- cord-023095-4dannjjm 4510 17 . . . cord-023095-4dannjjm 4511 1 There there EX cord-023095-4dannjjm 4511 2 were be VBD cord-023095-4dannjjm 4511 3 no no DT cord-023095-4dannjjm 4511 4 significant significant JJ cord-023095-4dannjjm 4511 5 differences difference NNS cord-023095-4dannjjm 4511 6 in in IN cord-023095-4dannjjm 4511 7 presence presence NN cord-023095-4dannjjm 4511 8 of of IN cord-023095-4dannjjm 4511 9 spinal spinal JJ cord-023095-4dannjjm 4511 10 pain pain NN cord-023095-4dannjjm 4511 11 or or CC cord-023095-4dannjjm 4511 12 neurological neurological JJ cord-023095-4dannjjm 4511 13 signs sign NNS cord-023095-4dannjjm 4511 14 between between IN cord-023095-4dannjjm 4511 15 dogs dog NNS cord-023095-4dannjjm 4511 16 with with IN cord-023095-4dannjjm 4511 17 or or CC cord-023095-4dannjjm 4511 18 without without IN cord-023095-4dannjjm 4511 19 skull skull NN cord-023095-4dannjjm 4511 20 abnormalities abnormality NNS cord-023095-4dannjjm 4511 21 . . . cord-023095-4dannjjm 4512 1 There there EX cord-023095-4dannjjm 4512 2 was be VBD cord-023095-4dannjjm 4512 3 a a DT cord-023095-4dannjjm 4512 4 significant significant JJ cord-023095-4dannjjm 4512 5 negative negative JJ cord-023095-4dannjjm 4512 6 association association NN cord-023095-4dannjjm 4512 7 of of IN cord-023095-4dannjjm 4512 8 ventricular ventricular JJ cord-023095-4dannjjm 4512 9 percentage percentage NN cord-023095-4dannjjm 4512 10 and and CC cord-023095-4dannjjm 4512 11 cerebellar cerebellar JJ cord-023095-4dannjjm 4512 12 percentage percentage NN cord-023095-4dannjjm 4513 1 ( ( -LRB- cord-023095-4dannjjm 4513 2 p p NN cord-023095-4dannjjm 4513 3 o o CD cord-023095-4dannjjm 4513 4 0.0001 0.0001 CD cord-023095-4dannjjm 4513 5 ) ) -RRB- cord-023095-4dannjjm 4513 6 . . . cord-023095-4dannjjm 4514 1 There there EX cord-023095-4dannjjm 4514 2 was be VBD cord-023095-4dannjjm 4514 3 a a DT cord-023095-4dannjjm 4514 4 significant significant JJ cord-023095-4dannjjm 4514 5 association association NN cord-023095-4dannjjm 4514 6 of of IN cord-023095-4dannjjm 4514 7 ventricular ventricular JJ cord-023095-4dannjjm 4514 8 percentage percentage NN cord-023095-4dannjjm 4514 9 with with IN cord-023095-4dannjjm 4514 10 syrinx syrinx NNP cord-023095-4dannjjm 4514 11 percentage percentage NN cord-023095-4dannjjm 4514 12 ( ( -LRB- cord-023095-4dannjjm 4514 13 p p NN cord-023095-4dannjjm 4514 14 5 5 CD cord-023095-4dannjjm 4514 15 0.0015 0.0015 CD cord-023095-4dannjjm 4514 16 ) ) -RRB- cord-023095-4dannjjm 4514 17 and and CC cord-023095-4dannjjm 4514 18 height height NN cord-023095-4dannjjm 4514 19 ( ( -LRB- cord-023095-4dannjjm 4514 20 p p NN cord-023095-4dannjjm 4514 21 5 5 CD cord-023095-4dannjjm 4514 22 0.0007 0.0007 CD cord-023095-4dannjjm 4514 23 ) ) -RRB- cord-023095-4dannjjm 4514 24 . . . cord-023095-4dannjjm 4515 1 This this DT cord-023095-4dannjjm 4515 2 study study NN cord-023095-4dannjjm 4515 3 suggests suggest VBZ cord-023095-4dannjjm 4515 4 that that IN cord-023095-4dannjjm 4515 5 SM SM NNP cord-023095-4dannjjm 4515 6 and and CC cord-023095-4dannjjm 4515 7 CM CM NNP cord-023095-4dannjjm 4515 8 are be VBP cord-023095-4dannjjm 4515 9 prevalent prevalent JJ cord-023095-4dannjjm 4515 10 in in IN cord-023095-4dannjjm 4515 11 ABGs abg NNS cord-023095-4dannjjm 4515 12 . . . cord-023095-4dannjjm 4516 1 Syrinx Syrinx NNP cord-023095-4dannjjm 4516 2 size size NN cord-023095-4dannjjm 4516 3 and and CC cord-023095-4dannjjm 4516 4 extent extent NN cord-023095-4dannjjm 4516 5 are be VBP cord-023095-4dannjjm 4516 6 associated associate VBN cord-023095-4dannjjm 4516 7 with with IN cord-023095-4dannjjm 4516 8 neurological neurological JJ cord-023095-4dannjjm 4516 9 signs sign NNS cord-023095-4dannjjm 4516 10 and and CC cord-023095-4dannjjm 4516 11 ventriculomegaly ventriculomegaly NN cord-023095-4dannjjm 4516 12 is be VBZ cord-023095-4dannjjm 4516 13 associated associate VBN cord-023095-4dannjjm 4516 14 with with IN cord-023095-4dannjjm 4516 15 both both DT cord-023095-4dannjjm 4516 16 small small JJ cord-023095-4dannjjm 4516 17 cerebellar cerebellar JJ cord-023095-4dannjjm 4516 18 size size NN cord-023095-4dannjjm 4516 19 and and CC cord-023095-4dannjjm 4516 20 large large JJ cord-023095-4dannjjm 4516 21 syrinx syrinx JJ cord-023095-4dannjjm 4516 22 size size NN cord-023095-4dannjjm 4516 23 . . . cord-023095-4dannjjm 4517 1 However however RB cord-023095-4dannjjm 4517 2 , , , cord-023095-4dannjjm 4517 3 SM SM NNP cord-023095-4dannjjm 4517 4 may may MD cord-023095-4dannjjm 4517 5 not not RB cord-023095-4dannjjm 4517 6 be be VB cord-023095-4dannjjm 4517 7 associated associate VBN cord-023095-4dannjjm 4517 8 with with IN cord-023095-4dannjjm 4517 9 CM CM NNP cord-023095-4dannjjm 4517 10 as as IN cord-023095-4dannjjm 4517 11 defined define VBN cord-023095-4dannjjm 4517 12 by by IN cord-023095-4dannjjm 4517 13 cerebellar cerebellar JJ cord-023095-4dannjjm 4517 14 herniation herniation NN cord-023095-4dannjjm 4517 15 and and CC cord-023095-4dannjjm 4517 16 deviation deviation NN cord-023095-4dannjjm 4517 17 and and CC cord-023095-4dannjjm 4517 18 is be VBZ cord-023095-4dannjjm 4517 19 not not RB cord-023095-4dannjjm 4517 20 associated associate VBN cord-023095-4dannjjm 4517 21 with with IN cord-023095-4dannjjm 4517 22 CSF CSF NNP cord-023095-4dannjjm 4517 23 inflammation inflammation NN cord-023095-4dannjjm 4517 24 . . . cord-023095-4dannjjm 4518 1 The the DT cord-023095-4dannjjm 4518 2 power power NN cord-023095-4dannjjm 4518 3 tissue tissue NN cord-023095-4dannjjm 4518 4 resection resection NN cord-023095-4dannjjm 4518 5 device device NN cord-023095-4dannjjm 4518 6 ( ( -LRB- cord-023095-4dannjjm 4518 7 PTRD PTRD NNP cord-023095-4dannjjm 4518 8 ) ) -RRB- cord-023095-4dannjjm 4518 9 is be VBZ cord-023095-4dannjjm 4518 10 a a DT cord-023095-4dannjjm 4518 11 hand hand NN cord-023095-4dannjjm 4518 12 - - HYPH cord-023095-4dannjjm 4518 13 piece piece NN cord-023095-4dannjjm 4518 14 comprised comprise VBN cord-023095-4dannjjm 4518 15 of of IN cord-023095-4dannjjm 4518 16 an an DT cord-023095-4dannjjm 4518 17 outer outer JJ cord-023095-4dannjjm 4518 18 cannula cannula NN cord-023095-4dannjjm 4518 19 with with IN cord-023095-4dannjjm 4518 20 motor motor NN cord-023095-4dannjjm 4518 21 driven drive VBN cord-023095-4dannjjm 4518 22 vacuum vacuum NN cord-023095-4dannjjm 4518 23 - - HYPH cord-023095-4dannjjm 4518 24 assisted assist VBN cord-023095-4dannjjm 4518 25 inner inner JJ cord-023095-4dannjjm 4518 26 cutting cutting NN cord-023095-4dannjjm 4518 27 blade blade NN cord-023095-4dannjjm 4518 28 . . . cord-023095-4dannjjm 4519 1 This this DT cord-023095-4dannjjm 4519 2 device device NN cord-023095-4dannjjm 4519 3 was be VBD cord-023095-4dannjjm 4519 4 designed design VBN cord-023095-4dannjjm 4519 5 and and CC cord-023095-4dannjjm 4519 6 is be VBZ cord-023095-4dannjjm 4519 7 marketed market VBN cord-023095-4dannjjm 4519 8 for for IN cord-023095-4dannjjm 4519 9 human human JJ cord-023095-4dannjjm 4519 10 neurosurgical neurosurgical JJ cord-023095-4dannjjm 4519 11 brain brain NN cord-023095-4dannjjm 4519 12 / / SYM cord-023095-4dannjjm 4519 13 spinal spinal JJ cord-023095-4dannjjm 4519 14 cord cord NN cord-023095-4dannjjm 4519 15 tumor tumor NN cord-023095-4dannjjm 4519 16 resection resection NN cord-023095-4dannjjm 4519 17 . . . cord-023095-4dannjjm 4520 1 The the DT cord-023095-4dannjjm 4520 2 purpose purpose NN cord-023095-4dannjjm 4520 3 of of IN cord-023095-4dannjjm 4520 4 this this DT cord-023095-4dannjjm 4520 5 study study NN cord-023095-4dannjjm 4520 6 is be VBZ cord-023095-4dannjjm 4520 7 to to TO cord-023095-4dannjjm 4520 8 describe describe VB cord-023095-4dannjjm 4520 9 the the DT cord-023095-4dannjjm 4520 10 use use NN cord-023095-4dannjjm 4520 11 of of IN cord-023095-4dannjjm 4520 12 the the DT cord-023095-4dannjjm 4520 13 PTRD PTRD NNP cord-023095-4dannjjm 4520 14 for for IN cord-023095-4dannjjm 4520 15 intervertebral intervertebral JJ cord-023095-4dannjjm 4520 16 disc disc NN cord-023095-4dannjjm 4520 17 fenestration fenestration NN cord-023095-4dannjjm 4520 18 and and CC cord-023095-4dannjjm 4520 19 to to TO cord-023095-4dannjjm 4520 20 compare compare VB cord-023095-4dannjjm 4520 21 the the DT cord-023095-4dannjjm 4520 22 effectiveness effectiveness NN cord-023095-4dannjjm 4520 23 of of IN cord-023095-4dannjjm 4520 24 manual manual JJ cord-023095-4dannjjm 4520 25 fenestration fenestration NN cord-023095-4dannjjm 4520 26 to to IN cord-023095-4dannjjm 4520 27 that that DT cord-023095-4dannjjm 4520 28 of of IN cord-023095-4dannjjm 4520 29 the the DT cord-023095-4dannjjm 4520 30 PTRD PTRD NNP cord-023095-4dannjjm 4520 31 . . . cord-023095-4dannjjm 4521 1 Fifteen fifteen CD cord-023095-4dannjjm 4521 2 cadaveric cadaveric JJ cord-023095-4dannjjm 4521 3 lumbar lumbar NN cord-023095-4dannjjm 4521 4 spines spine NNS cord-023095-4dannjjm 4521 5 were be VBD cord-023095-4dannjjm 4521 6 randomly randomly RB cord-023095-4dannjjm 4521 7 placed place VBN cord-023095-4dannjjm 4521 8 into into IN cord-023095-4dannjjm 4521 9 three three CD cord-023095-4dannjjm 4521 10 study study NN cord-023095-4dannjjm 4521 11 groups group NNS cord-023095-4dannjjm 4521 12 : : : cord-023095-4dannjjm 4522 1 group group NN cord-023095-4dannjjm 4522 2 1 1 CD cord-023095-4dannjjm 4522 3 was be VBD cord-023095-4dannjjm 4522 4 the the DT cord-023095-4dannjjm 4522 5 control control NN cord-023095-4dannjjm 4522 6 group group NN cord-023095-4dannjjm 4522 7 on on IN cord-023095-4dannjjm 4522 8 which which WDT cord-023095-4dannjjm 4522 9 no no DT cord-023095-4dannjjm 4522 10 fenestrations fenestration NNS cord-023095-4dannjjm 4522 11 were be VBD cord-023095-4dannjjm 4522 12 performed perform VBN cord-023095-4dannjjm 4522 13 , , , cord-023095-4dannjjm 4522 14 group group NN cord-023095-4dannjjm 4522 15 2 2 CD cord-023095-4dannjjm 4522 16 was be VBD cord-023095-4dannjjm 4522 17 the the DT cord-023095-4dannjjm 4522 18 manual manual JJ cord-023095-4dannjjm 4522 19 fenestration fenestration NN cord-023095-4dannjjm 4522 20 group group NN cord-023095-4dannjjm 4522 21 and and CC cord-023095-4dannjjm 4522 22 group group NN cord-023095-4dannjjm 4522 23 3 3 CD cord-023095-4dannjjm 4523 1 was be VBD cord-023095-4dannjjm 4523 2 the the DT cord-023095-4dannjjm 4523 3 PTRD PTRD NNP cord-023095-4dannjjm 4523 4 fenestration fenestration NN cord-023095-4dannjjm 4523 5 group group NN cord-023095-4dannjjm 4523 6 . . . cord-023095-4dannjjm 4524 1 The the DT cord-023095-4dannjjm 4524 2 effectiveness effectiveness NN cord-023095-4dannjjm 4524 3 of of IN cord-023095-4dannjjm 4524 4 fenestration fenestration NN cord-023095-4dannjjm 4524 5 via via IN cord-023095-4dannjjm 4524 6 both both CC cord-023095-4dannjjm 4524 7 manual manual NN cord-023095-4dannjjm 4524 8 and and CC cord-023095-4dannjjm 4524 9 PTRD PTRD NNP cord-023095-4dannjjm 4524 10 was be VBD cord-023095-4dannjjm 4524 11 assessed assess VBN cord-023095-4dannjjm 4524 12 by by IN cord-023095-4dannjjm 4524 13 calculating calculate VBG cord-023095-4dannjjm 4524 14 the the DT cord-023095-4dannjjm 4524 15 ratio ratio NN cord-023095-4dannjjm 4524 16 of of IN cord-023095-4dannjjm 4524 17 remaining remain VBG cord-023095-4dannjjm 4524 18 nuclear nuclear JJ cord-023095-4dannjjm 4524 19 weight weight NN cord-023095-4dannjjm 4524 20 post post NN cord-023095-4dannjjm 4524 21 fenestration fenestration NN cord-023095-4dannjjm 4524 22 to to IN cord-023095-4dannjjm 4524 23 total total JJ cord-023095-4dannjjm 4524 24 nuclear nuclear JJ cord-023095-4dannjjm 4524 25 volume volume NN cord-023095-4dannjjm 4524 26 . . . cord-023095-4dannjjm 4525 1 Discs disc NNS cord-023095-4dannjjm 4525 2 with with IN cord-023095-4dannjjm 4525 3 lower low JJR cord-023095-4dannjjm 4525 4 ratios ratio NNS cord-023095-4dannjjm 4525 5 were be VBD cord-023095-4dannjjm 4525 6 more more RBR cord-023095-4dannjjm 4525 7 effectively effectively RB cord-023095-4dannjjm 4525 8 fenestrated fenestrate VBN cord-023095-4dannjjm 4525 9 . . . cord-023095-4dannjjm 4526 1 Results result NNS cord-023095-4dannjjm 4526 2 showed show VBD cord-023095-4dannjjm 4526 3 a a DT cord-023095-4dannjjm 4526 4 smaller small JJR cord-023095-4dannjjm 4526 5 ratio ratio NN cord-023095-4dannjjm 4526 6 of of IN cord-023095-4dannjjm 4526 7 post post JJ cord-023095-4dannjjm 4526 8 fenestration fenestration NN cord-023095-4dannjjm 4526 9 remaining remain VBG cord-023095-4dannjjm 4526 10 nuclear nuclear JJ cord-023095-4dannjjm 4526 11 weight weight NN cord-023095-4dannjjm 4526 12 to to IN cord-023095-4dannjjm 4526 13 nuclear nuclear JJ cord-023095-4dannjjm 4526 14 volume volume NN cord-023095-4dannjjm 4526 15 following follow VBG cord-023095-4dannjjm 4526 16 fenestration fenestration NN cord-023095-4dannjjm 4526 17 with with IN cord-023095-4dannjjm 4526 18 the the DT cord-023095-4dannjjm 4526 19 PTRD PTRD NNP cord-023095-4dannjjm 4526 20 ( ( -LRB- cord-023095-4dannjjm 4526 21 0.23 0.23 CD cord-023095-4dannjjm 4526 22 AE AE NNP cord-023095-4dannjjm 4526 23 0.09 0.09 CD cord-023095-4dannjjm 4526 24 ) ) -RRB- cord-023095-4dannjjm 4526 25 as as IN cord-023095-4dannjjm 4526 26 compared compare VBN cord-023095-4dannjjm 4526 27 to to IN cord-023095-4dannjjm 4526 28 manual manual JJ cord-023095-4dannjjm 4526 29 fenestration fenestration NN cord-023095-4dannjjm 4526 30 ( ( -LRB- cord-023095-4dannjjm 4526 31 0.30 0.30 CD cord-023095-4dannjjm 4526 32 AE AE NNP cord-023095-4dannjjm 4526 33 0.10 0.10 CD cord-023095-4dannjjm 4526 34 ) ) -RRB- cord-023095-4dannjjm 4526 35 . . . cord-023095-4dannjjm 4527 1 These these DT cord-023095-4dannjjm 4527 2 results result NNS cord-023095-4dannjjm 4527 3 did do VBD cord-023095-4dannjjm 4527 4 not not RB cord-023095-4dannjjm 4527 5 show show VB cord-023095-4dannjjm 4527 6 statistical statistical JJ cord-023095-4dannjjm 4527 7 significance significance NN cord-023095-4dannjjm 4527 8 . . . cord-023095-4dannjjm 4528 1 When when WRB cord-023095-4dannjjm 4528 2 fenestrated fenestrate VBN cord-023095-4dannjjm 4528 3 samples sample NNS cord-023095-4dannjjm 4528 4 were be VBD cord-023095-4dannjjm 4528 5 compared compare VBN cord-023095-4dannjjm 4528 6 to to TO cord-023095-4dannjjm 4528 7 control control NN cord-023095-4dannjjm 4528 8 samples sample NNS cord-023095-4dannjjm 4528 9 ( ( -LRB- cord-023095-4dannjjm 4528 10 0.39 0.39 CD cord-023095-4dannjjm 4528 11 AE AE NNP cord-023095-4dannjjm 4528 12 0.07 0.07 CD cord-023095-4dannjjm 4528 13 ) ) -RRB- cord-023095-4dannjjm 4528 14 , , , cord-023095-4dannjjm 4528 15 there there EX cord-023095-4dannjjm 4528 16 was be VBD cord-023095-4dannjjm 4528 17 a a DT cord-023095-4dannjjm 4528 18 statistically statistically RB cord-023095-4dannjjm 4528 19 significant significant JJ cord-023095-4dannjjm 4528 20 reduction reduction NN cord-023095-4dannjjm 4528 21 in in IN cord-023095-4dannjjm 4528 22 ratios ratio NNS cord-023095-4dannjjm 4528 23 . . . cord-023095-4dannjjm 4529 1 In in IN cord-023095-4dannjjm 4529 2 conclusion conclusion NN cord-023095-4dannjjm 4529 3 , , , cord-023095-4dannjjm 4529 4 the the DT cord-023095-4dannjjm 4529 5 PTRD PTRD NNP cord-023095-4dannjjm 4529 6 is be VBZ cord-023095-4dannjjm 4529 7 easy easy JJ cord-023095-4dannjjm 4529 8 to to TO cord-023095-4dannjjm 4529 9 use use VB cord-023095-4dannjjm 4529 10 and and CC cord-023095-4dannjjm 4529 11 is be VBZ cord-023095-4dannjjm 4529 12 as as RB cord-023095-4dannjjm 4529 13 effective effective JJ cord-023095-4dannjjm 4529 14 as as IN cord-023095-4dannjjm 4529 15 the the DT cord-023095-4dannjjm 4529 16 manual manual JJ cord-023095-4dannjjm 4529 17 technique technique NN cord-023095-4dannjjm 4529 18 for for IN cord-023095-4dannjjm 4529 19 canine canine JJ cord-023095-4dannjjm 4529 20 intervertebral intervertebral JJ cord-023095-4dannjjm 4529 21 disc disc NN cord-023095-4dannjjm 4529 22 fenestration fenestration NN cord-023095-4dannjjm 4529 23 . . . cord-023095-4dannjjm 4530 1 According accord VBG cord-023095-4dannjjm 4530 2 to to IN cord-023095-4dannjjm 4530 3 the the DT cord-023095-4dannjjm 4530 4 human human NN cord-023095-4dannjjm 4530 5 WHO who WP cord-023095-4dannjjm 4530 6 classification classification NN cord-023095-4dannjjm 4530 7 gliomatosis gliomatosis NN cord-023095-4dannjjm 4530 8 cerebri cerebri NNP cord-023095-4dannjjm 4530 9 ( ( -LRB- cord-023095-4dannjjm 4530 10 GC GC NNP cord-023095-4dannjjm 4530 11 ) ) -RRB- cord-023095-4dannjjm 4530 12 is be VBZ cord-023095-4dannjjm 4530 13 a a DT cord-023095-4dannjjm 4530 14 rare rare JJ cord-023095-4dannjjm 4530 15 astrocytic astrocytic JJ cord-023095-4dannjjm 4530 16 tumor tumor NN cord-023095-4dannjjm 4530 17 affecting affect VBG cord-023095-4dannjjm 4530 18 at at RB cord-023095-4dannjjm 4530 19 least least RBS cord-023095-4dannjjm 4530 20 three three CD cord-023095-4dannjjm 4530 21 lobes lobe NNS cord-023095-4dannjjm 4530 22 of of IN cord-023095-4dannjjm 4530 23 the the DT cord-023095-4dannjjm 4530 24 brain brain NN cord-023095-4dannjjm 4530 25 with with IN cord-023095-4dannjjm 4530 26 extensive extensive JJ cord-023095-4dannjjm 4530 27 infiltration infiltration NN cord-023095-4dannjjm 4530 28 , , , cord-023095-4dannjjm 4530 29 but but CC cord-023095-4dannjjm 4530 30 relative relative JJ cord-023095-4dannjjm 4530 31 preservation preservation NN cord-023095-4dannjjm 4530 32 of of IN cord-023095-4dannjjm 4530 33 brain brain NN cord-023095-4dannjjm 4530 34 architecture architecture NN cord-023095-4dannjjm 4530 35 . . . cord-023095-4dannjjm 4531 1 GC GC NNP cord-023095-4dannjjm 4531 2 has have VBZ cord-023095-4dannjjm 4531 3 not not RB cord-023095-4dannjjm 4531 4 been be VBN cord-023095-4dannjjm 4531 5 reported report VBN cord-023095-4dannjjm 4531 6 to to TO cord-023095-4dannjjm 4531 7 occur occur VB cord-023095-4dannjjm 4531 8 as as IN cord-023095-4dannjjm 4531 9 a a DT cord-023095-4dannjjm 4531 10 hereditary hereditary JJ cord-023095-4dannjjm 4531 11 disease disease NN cord-023095-4dannjjm 4531 12 , , , cord-023095-4dannjjm 4531 13 neither neither CC cord-023095-4dannjjm 4531 14 in in IN cord-023095-4dannjjm 4531 15 man man NN cord-023095-4dannjjm 4531 16 nor nor CC cord-023095-4dannjjm 4531 17 in in IN cord-023095-4dannjjm 4531 18 animals animal NNS cord-023095-4dannjjm 4531 19 . . . cord-023095-4dannjjm 4532 1 Here here RB cord-023095-4dannjjm 4532 2 , , , cord-023095-4dannjjm 4532 3 we -PRON- PRP cord-023095-4dannjjm 4532 4 report report VBP cord-023095-4dannjjm 4532 5 the the DT cord-023095-4dannjjm 4532 6 temporally temporally RB cord-023095-4dannjjm 4532 7 clustered cluster VBN cord-023095-4dannjjm 4532 8 occurrence occurrence NN cord-023095-4dannjjm 4532 9 of of IN cord-023095-4dannjjm 4532 10 GC GC NNP cord-023095-4dannjjm 4532 11 in in IN cord-023095-4dannjjm 4532 12 a a DT cord-023095-4dannjjm 4532 13 family family NN cord-023095-4dannjjm 4532 14 of of IN cord-023095-4dannjjm 4532 15 Bearded Bearded NNP cord-023095-4dannjjm 4532 16 collies collies NNPS cord-023095-4dannjjm 4532 17 . . . cord-023095-4dannjjm 4533 1 A a DT cord-023095-4dannjjm 4533 2 7 7 CD cord-023095-4dannjjm 4533 3 years year NNS cord-023095-4dannjjm 4533 4 old old JJ cord-023095-4dannjjm 4533 5 female female JJ cord-023095-4dannjjm 4533 6 Bearded Bearded NNP cord-023095-4dannjjm 4533 7 collie collie NN cord-023095-4dannjjm 4533 8 with with IN cord-023095-4dannjjm 4533 9 forebrain forebrain NN cord-023095-4dannjjm 4533 10 signs sign NNS cord-023095-4dannjjm 4533 11 was be VBD cord-023095-4dannjjm 4533 12 presented present VBN cord-023095-4dannjjm 4533 13 . . . cord-023095-4dannjjm 4534 1 Differentials differential NNS cord-023095-4dannjjm 4534 2 included include VBD cord-023095-4dannjjm 4534 3 inflammatory/ inflammatory/ NN cord-023095-4dannjjm 4534 4 infectious infectious JJ cord-023095-4dannjjm 4534 5 , , , cord-023095-4dannjjm 4534 6 metabolic/ metabolic/ JJ cord-023095-4dannjjm 4534 7 toxic toxic JJ cord-023095-4dannjjm 4534 8 , , , cord-023095-4dannjjm 4534 9 and and CC cord-023095-4dannjjm 4534 10 neoplastic neoplastic JJ cord-023095-4dannjjm 4534 11 diseases disease NNS cord-023095-4dannjjm 4534 12 . . . cord-023095-4dannjjm 4535 1 Within within IN cord-023095-4dannjjm 4535 2 a a DT cord-023095-4dannjjm 4535 3 time time NN cord-023095-4dannjjm 4535 4 period period NN cord-023095-4dannjjm 4535 5 of of IN cord-023095-4dannjjm 4535 6 12 12 CD cord-023095-4dannjjm 4535 7 months month NNS cord-023095-4dannjjm 4535 8 , , , cord-023095-4dannjjm 4535 9 3 3 CD cord-023095-4dannjjm 4535 10 offspring offspring NN cord-023095-4dannjjm 4535 11 of of IN cord-023095-4dannjjm 4535 12 this this DT cord-023095-4dannjjm 4535 13 bitch bitch NN cord-023095-4dannjjm 4535 14 were be VBD cord-023095-4dannjjm 4535 15 presented present VBN cord-023095-4dannjjm 4535 16 with with IN cord-023095-4dannjjm 4535 17 similar similar JJ cord-023095-4dannjjm 4535 18 clinical clinical JJ cord-023095-4dannjjm 4535 19 signs sign NNS cord-023095-4dannjjm 4535 20 . . . cord-023095-4dannjjm 4536 1 Two two CD cord-023095-4dannjjm 4536 2 dogs dog NNS cord-023095-4dannjjm 4536 3 were be VBD cord-023095-4dannjjm 4536 4 full full JJ cord-023095-4dannjjm 4536 5 siblings sibling NNS cord-023095-4dannjjm 4536 6 ( ( -LRB- cord-023095-4dannjjm 4536 7 2 2 CD cord-023095-4dannjjm 4536 8 males male NNS cord-023095-4dannjjm 4536 9 ) ) -RRB- cord-023095-4dannjjm 4536 10 . . . cord-023095-4dannjjm 4537 1 The the DT cord-023095-4dannjjm 4537 2 remaining remain VBG cord-023095-4dannjjm 4537 3 female female JJ cord-023095-4dannjjm 4537 4 dog dog NN cord-023095-4dannjjm 4537 5 originated originate VBD cord-023095-4dannjjm 4537 6 from from IN cord-023095-4dannjjm 4537 7 a a DT cord-023095-4dannjjm 4537 8 match match NN cord-023095-4dannjjm 4537 9 with with IN cord-023095-4dannjjm 4537 10 a a DT cord-023095-4dannjjm 4537 11 different different JJ cord-023095-4dannjjm 4537 12 male male JJ cord-023095-4dannjjm 4537 13 dog dog NN cord-023095-4dannjjm 4537 14 . . . cord-023095-4dannjjm 4538 1 MRI MRI NNP cord-023095-4dannjjm 4538 2 was be VBD cord-023095-4dannjjm 4538 3 performed perform VBN cord-023095-4dannjjm 4538 4 in in IN cord-023095-4dannjjm 4538 5 all all DT cord-023095-4dannjjm 4538 6 4 4 CD cord-023095-4dannjjm 4538 7 dogs dog NNS cord-023095-4dannjjm 4538 8 and and CC cord-023095-4dannjjm 4538 9 revealed reveal VBD cord-023095-4dannjjm 4538 10 a a DT cord-023095-4dannjjm 4538 11 diffuse diffuse JJ cord-023095-4dannjjm 4538 12 and and CC cord-023095-4dannjjm 4538 13 extensive extensive JJ cord-023095-4dannjjm 4538 14 intra intra JJ cord-023095-4dannjjm 4538 15 - - JJ cord-023095-4dannjjm 4538 16 axial axial JJ cord-023095-4dannjjm 4538 17 lesion lesion NN cord-023095-4dannjjm 4538 18 with with IN cord-023095-4dannjjm 4538 19 moderate moderate JJ cord-023095-4dannjjm 4538 20 mass mass JJ cord-023095-4dannjjm 4538 21 effect effect NN cord-023095-4dannjjm 4538 22 and and CC cord-023095-4dannjjm 4538 23 midline midline JJ cord-023095-4dannjjm 4538 24 shift shift NN cord-023095-4dannjjm 4538 25 . . . cord-023095-4dannjjm 4539 1 The the DT cord-023095-4dannjjm 4539 2 ill ill RB cord-023095-4dannjjm 4539 3 defined define VBN cord-023095-4dannjjm 4539 4 lesion lesion NN cord-023095-4dannjjm 4539 5 showed show VBD cord-023095-4dannjjm 4539 6 mainly mainly RB cord-023095-4dannjjm 4539 7 a a DT cord-023095-4dannjjm 4539 8 white white JJ cord-023095-4dannjjm 4539 9 matter matter NN cord-023095-4dannjjm 4539 10 distribution distribution NN cord-023095-4dannjjm 4539 11 with with IN cord-023095-4dannjjm 4539 12 hyperintense hyperintense NN cord-023095-4dannjjm 4539 13 signal signal NN cord-023095-4dannjjm 4539 14 in in IN cord-023095-4dannjjm 4539 15 T2-w T2-w NNP cord-023095-4dannjjm 4539 16 and and CC cord-023095-4dannjjm 4539 17 FLAIR flair NN cord-023095-4dannjjm 4539 18 images image NNS cord-023095-4dannjjm 4539 19 and and CC cord-023095-4dannjjm 4539 20 iso iso NN cord-023095-4dannjjm 4539 21 - - HYPH cord-023095-4dannjjm 4539 22 to to IN cord-023095-4dannjjm 4539 23 hypointense hypointense NN cord-023095-4dannjjm 4539 24 signal signal NN cord-023095-4dannjjm 4539 25 in in IN cord-023095-4dannjjm 4539 26 T1-w t1-w NN cord-023095-4dannjjm 4539 27 images image NNS cord-023095-4dannjjm 4539 28 without without IN cord-023095-4dannjjm 4539 29 contrast contrast NN cord-023095-4dannjjm 4539 30 enhancement enhancement NN cord-023095-4dannjjm 4539 31 . . . cord-023095-4dannjjm 4540 1 The the DT cord-023095-4dannjjm 4540 2 lesion lesion NN cord-023095-4dannjjm 4540 3 was be VBD cord-023095-4dannjjm 4540 4 bilateral bilateral JJ cord-023095-4dannjjm 4540 5 in in IN cord-023095-4dannjjm 4540 6 all all DT cord-023095-4dannjjm 4540 7 cases case NNS cord-023095-4dannjjm 4540 8 , , , cord-023095-4dannjjm 4540 9 continued continue VBD cord-023095-4dannjjm 4540 10 along along IN cord-023095-4dannjjm 4540 11 the the DT cord-023095-4dannjjm 4540 12 white white JJ cord-023095-4dannjjm 4540 13 matter matter NN cord-023095-4dannjjm 4540 14 extending extend VBG cord-023095-4dannjjm 4540 15 partially partially RB cord-023095-4dannjjm 4540 16 into into IN cord-023095-4dannjjm 4540 17 the the DT cord-023095-4dannjjm 4540 18 gray gray JJ cord-023095-4dannjjm 4540 19 matter matter NN cord-023095-4dannjjm 4540 20 with with IN cord-023095-4dannjjm 4540 21 contact contact NN cord-023095-4dannjjm 4540 22 to to IN cord-023095-4dannjjm 4540 23 the the DT cord-023095-4dannjjm 4540 24 brain brain NN cord-023095-4dannjjm 4540 25 surface surface NN cord-023095-4dannjjm 4540 26 . . . cord-023095-4dannjjm 4541 1 Neuropathology Neuropathology NNP cord-023095-4dannjjm 4541 2 revealed reveal VBD cord-023095-4dannjjm 4541 3 a a DT cord-023095-4dannjjm 4541 4 diffuse diffuse JJ cord-023095-4dannjjm 4541 5 and and CC cord-023095-4dannjjm 4541 6 extensive extensive JJ cord-023095-4dannjjm 4541 7 infiltration infiltration NN cord-023095-4dannjjm 4541 8 of of IN cord-023095-4dannjjm 4541 9 the the DT cord-023095-4dannjjm 4541 10 brain brain NN cord-023095-4dannjjm 4541 11 and and CC cord-023095-4dannjjm 4541 12 spinal spinal JJ cord-023095-4dannjjm 4541 13 cord cord NN cord-023095-4dannjjm 4541 14 by by IN cord-023095-4dannjjm 4541 15 a a DT cord-023095-4dannjjm 4541 16 neoplastic neoplastic JJ cord-023095-4dannjjm 4541 17 glial glial JJ cord-023095-4dannjjm 4541 18 cell cell NN cord-023095-4dannjjm 4541 19 population population NN cord-023095-4dannjjm 4541 20 involving involve VBG cord-023095-4dannjjm 4541 21 white white JJ cord-023095-4dannjjm 4541 22 and and CC cord-023095-4dannjjm 4541 23 gray gray JJ cord-023095-4dannjjm 4541 24 matter matter NN cord-023095-4dannjjm 4541 25 of of IN cord-023095-4dannjjm 4541 26 both both DT cord-023095-4dannjjm 4541 27 hemispheres hemisphere NNS cord-023095-4dannjjm 4541 28 , , , cord-023095-4dannjjm 4541 29 thalamus thalamus NN cord-023095-4dannjjm 4541 30 , , , cord-023095-4dannjjm 4541 31 brainstem brainstem NN cord-023095-4dannjjm 4541 32 and and CC cord-023095-4dannjjm 4541 33 cerebellum cerebellum NN cord-023095-4dannjjm 4541 34 in in IN cord-023095-4dannjjm 4541 35 all all DT cord-023095-4dannjjm 4541 36 4 4 CD cord-023095-4dannjjm 4541 37 dogs dog NNS cord-023095-4dannjjm 4541 38 . . . cord-023095-4dannjjm 4542 1 Based base VBN cord-023095-4dannjjm 4542 2 on on IN cord-023095-4dannjjm 4542 3 the the DT cord-023095-4dannjjm 4542 4 cell cell NN cord-023095-4dannjjm 4542 5 morphology morphology NN cord-023095-4dannjjm 4542 6 and and CC cord-023095-4dannjjm 4542 7 immunoexpression immunoexpression NN cord-023095-4dannjjm 4542 8 of of IN cord-023095-4dannjjm 4542 9 glial glial JJ cord-023095-4dannjjm 4542 10 fibrillary fibrillary JJ cord-023095-4dannjjm 4542 11 astrocytic astrocytic JJ cord-023095-4dannjjm 4542 12 protein protein NN cord-023095-4dannjjm 4542 13 by by IN cord-023095-4dannjjm 4542 14 neoplastic neoplastic JJ cord-023095-4dannjjm 4542 15 cells cell NNS cord-023095-4dannjjm 4542 16 diagnosis diagnosis NN cord-023095-4dannjjm 4542 17 of of IN cord-023095-4dannjjm 4542 18 GC GC NNP cord-023095-4dannjjm 4542 19 was be VBD cord-023095-4dannjjm 4542 20 made make VBN cord-023095-4dannjjm 4542 21 . . . cord-023095-4dannjjm 4543 1 This this DT cord-023095-4dannjjm 4543 2 is be VBZ cord-023095-4dannjjm 4543 3 the the DT cord-023095-4dannjjm 4543 4 first first JJ cord-023095-4dannjjm 4543 5 report report NN cord-023095-4dannjjm 4543 6 of of IN cord-023095-4dannjjm 4543 7 familial familial JJ cord-023095-4dannjjm 4543 8 occurrence occurrence NN cord-023095-4dannjjm 4543 9 of of IN cord-023095-4dannjjm 4543 10 GC GC NNP cord-023095-4dannjjm 4543 11 , , , cord-023095-4dannjjm 4543 12 which which WDT cord-023095-4dannjjm 4543 13 is be VBZ cord-023095-4dannjjm 4543 14 likely likely RB cord-023095-4dannjjm 4543 15 the the DT cord-023095-4dannjjm 4543 16 result result NN cord-023095-4dannjjm 4543 17 of of IN cord-023095-4dannjjm 4543 18 a a DT cord-023095-4dannjjm 4543 19 germ germ NN cord-023095-4dannjjm 4543 20 - - HYPH cord-023095-4dannjjm 4543 21 line line NN cord-023095-4dannjjm 4543 22 mutation mutation NN cord-023095-4dannjjm 4543 23 . . . cord-023095-4dannjjm 4544 1 Several several JJ cord-023095-4dannjjm 4544 2 human human JJ cord-023095-4dannjjm 4544 3 hereditary hereditary JJ cord-023095-4dannjjm 4544 4 cancer cancer NN cord-023095-4dannjjm 4544 5 syndromes syndrome NNS cord-023095-4dannjjm 4544 6 are be VBP cord-023095-4dannjjm 4544 7 associated associate VBN cord-023095-4dannjjm 4544 8 with with IN cord-023095-4dannjjm 4544 9 CNS CNS NNP cord-023095-4dannjjm 4544 10 tumors tumor NNS cord-023095-4dannjjm 4544 11 including include VBG cord-023095-4dannjjm 4544 12 amongst amongst IN cord-023095-4dannjjm 4544 13 others other NNS cord-023095-4dannjjm 4544 14 the the DT cord-023095-4dannjjm 4544 15 Li Li NNP cord-023095-4dannjjm 4544 16 - - HYPH cord-023095-4dannjjm 4544 17 Fraumeni Fraumeni NNP cord-023095-4dannjjm 4544 18 cancer cancer NN cord-023095-4dannjjm 4544 19 family family NN cord-023095-4dannjjm 4544 20 syndrome syndrome NN cord-023095-4dannjjm 4544 21 ( ( -LRB- cord-023095-4dannjjm 4544 22 p53 p53 NN cord-023095-4dannjjm 4544 23 mutation mutation NN cord-023095-4dannjjm 4544 24 ) ) -RRB- cord-023095-4dannjjm 4544 25 , , , cord-023095-4dannjjm 4544 26 neurofibromatosis neurofibromatosis NN cord-023095-4dannjjm 4544 27 ( ( -LRB- cord-023095-4dannjjm 4544 28 type type NN cord-023095-4dannjjm 4544 29 1 1 CD cord-023095-4dannjjm 4544 30 and and CC cord-023095-4dannjjm 4544 31 2 2 CD cord-023095-4dannjjm 4544 32 ) ) -RRB- cord-023095-4dannjjm 4544 33 ( ( -LRB- cord-023095-4dannjjm 4544 34 neurofibromin neurofibromin NNP cord-023095-4dannjjm 4544 35 , , , cord-023095-4dannjjm 4544 36 merlin merlin NNP cord-023095-4dannjjm 4544 37 mutation mutation NN cord-023095-4dannjjm 4544 38 ) ) -RRB- cord-023095-4dannjjm 4544 39 , , , cord-023095-4dannjjm 4544 40 and and CC cord-023095-4dannjjm 4544 41 tuberous tuberous JJ cord-023095-4dannjjm 4544 42 sclerosis sclerosis NN cord-023095-4dannjjm 4544 43 ( ( -LRB- cord-023095-4dannjjm 4544 44 hamartin hamartin NNP cord-023095-4dannjjm 4544 45 , , , cord-023095-4dannjjm 4544 46 tuberin tuberin NNP cord-023095-4dannjjm 4544 47 mutation mutation NN cord-023095-4dannjjm 4544 48 ) ) -RRB- cord-023095-4dannjjm 4544 49 . . . cord-023095-4dannjjm 4545 1 Furthermore furthermore RB cord-023095-4dannjjm 4545 2 , , , cord-023095-4dannjjm 4545 3 familial familial JJ cord-023095-4dannjjm 4545 4 clustering clustering NN cord-023095-4dannjjm 4545 5 of of IN cord-023095-4dannjjm 4545 6 human human JJ cord-023095-4dannjjm 4545 7 gliomas glioma NNS cord-023095-4dannjjm 4545 8 unassociated unassociate VBN cord-023095-4dannjjm 4545 9 to to IN cord-023095-4dannjjm 4545 10 the the DT cord-023095-4dannjjm 4545 11 known know VBN cord-023095-4dannjjm 4545 12 inherited inherit VBN cord-023095-4dannjjm 4545 13 cancer cancer NN cord-023095-4dannjjm 4545 14 syndromes syndrome NNS cord-023095-4dannjjm 4545 15 has have VBZ cord-023095-4dannjjm 4545 16 been be VBN cord-023095-4dannjjm 4545 17 described describe VBN cord-023095-4dannjjm 4545 18 . . . cord-023095-4dannjjm 4546 1 In in IN cord-023095-4dannjjm 4546 2 the the DT cord-023095-4dannjjm 4546 3 dog dog NN cord-023095-4dannjjm 4546 4 , , , cord-023095-4dannjjm 4546 5 hereditary hereditary JJ cord-023095-4dannjjm 4546 6 CNS CNS NNP cord-023095-4dannjjm 4546 7 tumors tumor NNS cord-023095-4dannjjm 4546 8 are be VBP cord-023095-4dannjjm 4546 9 not not RB cord-023095-4dannjjm 4546 10 known know VBN cord-023095-4dannjjm 4546 11 . . . cord-023095-4dannjjm 4547 1 The the DT cord-023095-4dannjjm 4547 2 exact exact JJ cord-023095-4dannjjm 4547 3 mode mode NN cord-023095-4dannjjm 4547 4 of of IN cord-023095-4dannjjm 4547 5 inheritance inheritance NN cord-023095-4dannjjm 4547 6 and and CC cord-023095-4dannjjm 4547 7 putative putative JJ cord-023095-4dannjjm 4547 8 gene gene NN cord-023095-4dannjjm 4547 9 mutations mutation NNS cord-023095-4dannjjm 4547 10 of of IN cord-023095-4dannjjm 4547 11 GC GC NNP cord-023095-4dannjjm 4547 12 in in IN cord-023095-4dannjjm 4547 13 this this DT cord-023095-4dannjjm 4547 14 Bearded Bearded NNP cord-023095-4dannjjm 4547 15 collie collie NN cord-023095-4dannjjm 4547 16 family family NN cord-023095-4dannjjm 4547 17 are be VBP cord-023095-4dannjjm 4547 18 currently currently RB cord-023095-4dannjjm 4547 19 under under IN cord-023095-4dannjjm 4547 20 investigation investigation NN cord-023095-4dannjjm 4547 21 . . . cord-023095-4dannjjm 4548 1 Preliminary preliminary JJ cord-023095-4dannjjm 4548 2 results result NNS cord-023095-4dannjjm 4548 3 are be VBP cord-023095-4dannjjm 4548 4 consistent consistent JJ cord-023095-4dannjjm 4548 5 with with IN cord-023095-4dannjjm 4548 6 a a DT cord-023095-4dannjjm 4548 7 monogenic monogenic JJ cord-023095-4dannjjm 4548 8 autosomal autosomal JJ cord-023095-4dannjjm 4548 9 dominant dominant JJ cord-023095-4dannjjm 4548 10 mode mode NN cord-023095-4dannjjm 4548 11 of of IN cord-023095-4dannjjm 4548 12 inheritance inheritance NN cord-023095-4dannjjm 4548 13 , , , cord-023095-4dannjjm 4548 14 although although IN cord-023095-4dannjjm 4548 15 a a DT cord-023095-4dannjjm 4548 16 recessive recessive JJ cord-023095-4dannjjm 4548 17 inheritance inheritance NN cord-023095-4dannjjm 4548 18 can can MD cord-023095-4dannjjm 4548 19 not not RB cord-023095-4dannjjm 4548 20 be be VB cord-023095-4dannjjm 4548 21 completely completely RB cord-023095-4dannjjm 4548 22 ruled rule VBN cord-023095-4dannjjm 4548 23 out out RP cord-023095-4dannjjm 4548 24 at at IN cord-023095-4dannjjm 4548 25 this this DT cord-023095-4dannjjm 4548 26 time time NN cord-023095-4dannjjm 4548 27 . . . cord-023095-4dannjjm 4549 1 Mutations mutation NNS cord-023095-4dannjjm 4549 2 in in IN cord-023095-4dannjjm 4549 3 the the DT cord-023095-4dannjjm 4549 4 TP53 TP53 NNP cord-023095-4dannjjm 4549 5 gene gene NN cord-023095-4dannjjm 4549 6 were be VBD cord-023095-4dannjjm 4549 7 not not RB cord-023095-4dannjjm 4549 8 found find VBN cord-023095-4dannjjm 4549 9 following follow VBG cord-023095-4dannjjm 4549 10 amplification amplification NN cord-023095-4dannjjm 4549 11 and and CC cord-023095-4dannjjm 4549 12 sequencing sequencing NN cord-023095-4dannjjm 4549 13 of of IN cord-023095-4dannjjm 4549 14 exons exon NNS cord-023095-4dannjjm 4549 15 5 5 CD cord-023095-4dannjjm 4549 16 - - SYM cord-023095-4dannjjm 4549 17 8 8 CD cord-023095-4dannjjm 4549 18 in in IN cord-023095-4dannjjm 4549 19 2 2 CD cord-023095-4dannjjm 4549 20 affected affect VBN cord-023095-4dannjjm 4549 21 dogs dog NNS cord-023095-4dannjjm 4549 22 . . . cord-023095-4dannjjm 4550 1 Previously previously RB cord-023095-4dannjjm 4550 2 presented present VBN cord-023095-4dannjjm 4550 3 at at IN cord-023095-4dannjjm 4550 4 the the DT cord-023095-4dannjjm 4550 5 ECVN ECVN NNP cord-023095-4dannjjm 4550 6 annual annual JJ cord-023095-4dannjjm 4550 7 meeting meeting NN cord-023095-4dannjjm 4550 8 in in IN cord-023095-4dannjjm 4550 9 Cambridge Cambridge NNP cord-023095-4dannjjm 4550 10 , , , cord-023095-4dannjjm 4550 11 UK UK NNP cord-023095-4dannjjm 4550 12 . . . cord-023095-4dannjjm 4551 1 The the DT cord-023095-4dannjjm 4551 2 GM GM NNP cord-023095-4dannjjm 4551 3 2 2 CD cord-023095-4dannjjm 4551 4 gangliosidoses gangliosidose NNS cord-023095-4dannjjm 4551 5 are be VBP cord-023095-4dannjjm 4551 6 characterized characterize VBN cord-023095-4dannjjm 4551 7 by by IN cord-023095-4dannjjm 4551 8 a a DT cord-023095-4dannjjm 4551 9 deficiency deficiency NN cord-023095-4dannjjm 4551 10 of of IN cord-023095-4dannjjm 4551 11 bhexosaminidase bhexosaminidase NNP cord-023095-4dannjjm 4551 12 . . . cord-023095-4dannjjm 4552 1 There there EX cord-023095-4dannjjm 4552 2 are be VBP cord-023095-4dannjjm 4552 3 two two CD cord-023095-4dannjjm 4552 4 isoforms isoform NNS cord-023095-4dannjjm 4552 5 : : : cord-023095-4dannjjm 4552 6 Hex Hex NNP cord-023095-4dannjjm 4552 7 A A NNP cord-023095-4dannjjm 4552 8 composed compose VBN cord-023095-4dannjjm 4552 9 of of IN cord-023095-4dannjjm 4552 10 an an DT cord-023095-4dannjjm 4552 11 a a NN cord-023095-4dannjjm 4552 12 and and CC cord-023095-4dannjjm 4552 13 b b NN cord-023095-4dannjjm 4552 14 subunit subunit NN cord-023095-4dannjjm 4552 15 encoded encode VBN cord-023095-4dannjjm 4552 16 by by IN cord-023095-4dannjjm 4552 17 HEXA HEXA NNP cord-023095-4dannjjm 4552 18 and and CC cord-023095-4dannjjm 4552 19 HEXB HEXB NNP cord-023095-4dannjjm 4552 20 genes gene NNS cord-023095-4dannjjm 4552 21 respectively respectively RB cord-023095-4dannjjm 4552 22 and and CC cord-023095-4dannjjm 4552 23 Hex Hex NNP cord-023095-4dannjjm 4552 24 B B NNP cord-023095-4dannjjm 4552 25 with with IN cord-023095-4dannjjm 4552 26 two two CD cord-023095-4dannjjm 4552 27 b b NN cord-023095-4dannjjm 4552 28 subunits subunit NNS cord-023095-4dannjjm 4552 29 . . . cord-023095-4dannjjm 4553 1 Hex Hex NNP cord-023095-4dannjjm 4553 2 A A NNP cord-023095-4dannjjm 4553 3 requires require VBZ cord-023095-4dannjjm 4553 4 an an DT cord-023095-4dannjjm 4553 5 activator activator NN cord-023095-4dannjjm 4553 6 encoded encode VBN cord-023095-4dannjjm 4553 7 by by IN cord-023095-4dannjjm 4553 8 GM2A. GM2A. NNPS cord-023095-4dannjjm 4553 9 Two two CD cord-023095-4dannjjm 4553 10 Japanese japanese JJ cord-023095-4dannjjm 4553 11 chin chin NN cord-023095-4dannjjm 4553 12 dogs dog NNS cord-023095-4dannjjm 4553 13 with with IN cord-023095-4dannjjm 4553 14 confirmed confirm VBN cord-023095-4dannjjm 4553 15 GM GM NNP cord-023095-4dannjjm 4553 16 2 2 CD cord-023095-4dannjjm 4553 17 gangliosidosis gangliosidosis NNP cord-023095-4dannjjm 4553 18 showed show VBD cord-023095-4dannjjm 4553 19 elevated elevated JJ cord-023095-4dannjjm 4553 20 total total JJ cord-023095-4dannjjm 4553 21 hexosaminidase hexosaminidase NN cord-023095-4dannjjm 4553 22 and and CC cord-023095-4dannjjm 4553 23 normal normal JJ cord-023095-4dannjjm 4554 1 hexosaminidase hexosaminidase NNP cord-023095-4dannjjm 4554 2 A a DT cord-023095-4dannjjm 4554 3 activity activity NN cord-023095-4dannjjm 4554 4 , , , cord-023095-4dannjjm 4554 5 a a DT cord-023095-4dannjjm 4554 6 pattern pattern NN cord-023095-4dannjjm 4554 7 associated associate VBN cord-023095-4dannjjm 4554 8 with with IN cord-023095-4dannjjm 4554 9 the the DT cord-023095-4dannjjm 4554 10 AB AB NNP cord-023095-4dannjjm 4554 11 variant variant NN cord-023095-4dannjjm 4554 12 in in IN cord-023095-4dannjjm 4554 13 humans human NNS cord-023095-4dannjjm 4554 14 and and CC cord-023095-4dannjjm 4554 15 consistent consistent JJ cord-023095-4dannjjm 4554 16 with with IN cord-023095-4dannjjm 4554 17 prior prior JJ cord-023095-4dannjjm 4554 18 reports report NNS cord-023095-4dannjjm 4554 19 in in IN cord-023095-4dannjjm 4554 20 the the DT cord-023095-4dannjjm 4554 21 breed breed NN cord-023095-4dannjjm 4554 22 . . . cord-023095-4dannjjm 4555 1 This this DT cord-023095-4dannjjm 4555 2 study study NN cord-023095-4dannjjm 4555 3 was be VBD cord-023095-4dannjjm 4555 4 performed perform VBN cord-023095-4dannjjm 4555 5 to to TO cord-023095-4dannjjm 4555 6 identify identify VB cord-023095-4dannjjm 4555 7 the the DT cord-023095-4dannjjm 4555 8 mutation mutation NN cord-023095-4dannjjm 4555 9 responsible responsible JJ cord-023095-4dannjjm 4555 10 using use VBG cord-023095-4dannjjm 4555 11 resequencing resequencing NN cord-023095-4dannjjm 4555 12 with with IN cord-023095-4dannjjm 4555 13 an an DT cord-023095-4dannjjm 4555 14 Applied Applied NNP cord-023095-4dannjjm 4555 15 Biosystems Biosystems NNP cord-023095-4dannjjm 4555 16 3730xl 3730xl NN cord-023095-4dannjjm 4555 17 DNA dna NN cord-023095-4dannjjm 4555 18 analyzer analyzer NN cord-023095-4dannjjm 4555 19 as as IN cord-023095-4dannjjm 4555 20 previously previously RB cord-023095-4dannjjm 4555 21 described describe VBN cord-023095-4dannjjm 4555 22 ( ( -LRB- cord-023095-4dannjjm 4555 23 Awano Awano NNP cord-023095-4dannjjm 4555 24 2009 2009 CD cord-023095-4dannjjm 4555 25 ) ) -RRB- cord-023095-4dannjjm 4555 26 . . . cord-023095-4dannjjm 4556 1 Mutations mutation NNS cord-023095-4dannjjm 4556 2 in in IN cord-023095-4dannjjm 4556 3 GM2A GM2A NNS cord-023095-4dannjjm 4556 4 cause cause VB cord-023095-4dannjjm 4556 5 the the DT cord-023095-4dannjjm 4556 6 AB AB NNP cord-023095-4dannjjm 4556 7 variant variant NN cord-023095-4dannjjm 4556 8 in in IN cord-023095-4dannjjm 4556 9 humans human NNS cord-023095-4dannjjm 4556 10 , , , cord-023095-4dannjjm 4556 11 but but CC cord-023095-4dannjjm 4556 12 resequencing resequencing NN cord-023095-4dannjjm 4556 13 GM2A GM2A NNP cord-023095-4dannjjm 4556 14 revealed reveal VBD cord-023095-4dannjjm 4556 15 no no DT cord-023095-4dannjjm 4556 16 mutation mutation NN cord-023095-4dannjjm 4556 17 that that WDT cord-023095-4dannjjm 4556 18 could could MD cord-023095-4dannjjm 4556 19 account account VB cord-023095-4dannjjm 4556 20 for for IN cord-023095-4dannjjm 4556 21 the the DT cord-023095-4dannjjm 4556 22 disease disease NN cord-023095-4dannjjm 4556 23 . . . cord-023095-4dannjjm 4557 1 Resequencing resequence VBG cord-023095-4dannjjm 4557 2 HEXA HEXA NNP cord-023095-4dannjjm 4557 3 and and CC cord-023095-4dannjjm 4557 4 HEXB HEXB NNP cord-023095-4dannjjm 4557 5 revealed reveal VBD cord-023095-4dannjjm 4557 6 a a DT cord-023095-4dannjjm 4557 7 c.967 c.967 NN cord-023095-4dannjjm 4557 8 G g NN cord-023095-4dannjjm 4557 9 4 4 CD cord-023095-4dannjjm 4557 10 A a DT cord-023095-4dannjjm 4557 11 mutation mutation NN cord-023095-4dannjjm 4557 12 in in IN cord-023095-4dannjjm 4557 13 HEXA HEXA NNP cord-023095-4dannjjm 4557 14 which which WDT cord-023095-4dannjjm 4557 15 was be VBD cord-023095-4dannjjm 4557 16 homozygous homozygous JJ cord-023095-4dannjjm 4557 17 in in IN cord-023095-4dannjjm 4557 18 both both DT cord-023095-4dannjjm 4557 19 affected affect VBN cord-023095-4dannjjm 4557 20 dogs dog NNS cord-023095-4dannjjm 4557 21 . . . cord-023095-4dannjjm 4558 1 Sixty sixty CD cord-023095-4dannjjm 4558 2 - - HYPH cord-023095-4dannjjm 4558 3 five five CD cord-023095-4dannjjm 4558 4 normal normal JJ cord-023095-4dannjjm 4558 5 Japanese japanese JJ cord-023095-4dannjjm 4558 6 Chin Chin NNP cord-023095-4dannjjm 4558 7 dogs dog NNS cord-023095-4dannjjm 4558 8 were be VBD cord-023095-4dannjjm 4558 9 screened screen VBN cord-023095-4dannjjm 4558 10 for for IN cord-023095-4dannjjm 4558 11 the the DT cord-023095-4dannjjm 4558 12 mutant mutant JJ cord-023095-4dannjjm 4558 13 allele allele NN cord-023095-4dannjjm 4558 14 ; ; : cord-023095-4dannjjm 4558 15 60 60 CD cord-023095-4dannjjm 4558 16 were be VBD cord-023095-4dannjjm 4558 17 homozygous homozygous JJ cord-023095-4dannjjm 4558 18 for for IN cord-023095-4dannjjm 4558 19 the the DT cord-023095-4dannjjm 4558 20 ancestral ancestral JJ cord-023095-4dannjjm 4558 21 allele allele NN cord-023095-4dannjjm 4558 22 and and CC cord-023095-4dannjjm 4558 23 5 5 CD cord-023095-4dannjjm 4558 24 heterozygous heterozygous JJ cord-023095-4dannjjm 4558 25 . . . cord-023095-4dannjjm 4559 1 This this DT cord-023095-4dannjjm 4559 2 mutation mutation NN cord-023095-4dannjjm 4559 3 predicts predict VBZ cord-023095-4dannjjm 4559 4 a a DT cord-023095-4dannjjm 4559 5 p.323E p.323E NNP cord-023095-4dannjjm 4559 6 4 4 CD cord-023095-4dannjjm 4559 7 K k NN cord-023095-4dannjjm 4559 8 substitution substitution NN cord-023095-4dannjjm 4559 9 affecting affect VBG cord-023095-4dannjjm 4559 10 one one CD cord-023095-4dannjjm 4559 11 of of IN cord-023095-4dannjjm 4559 12 two two CD cord-023095-4dannjjm 4559 13 primary primary JJ cord-023095-4dannjjm 4559 14 active active JJ cord-023095-4dannjjm 4559 15 - - HYPH cord-023095-4dannjjm 4559 16 site site NN cord-023095-4dannjjm 4559 17 amino amino NN cord-023095-4dannjjm 4559 18 acids acid NNS cord-023095-4dannjjm 4559 19 that that WDT cord-023095-4dannjjm 4559 20 participate participate VBP cord-023095-4dannjjm 4559 21 in in IN cord-023095-4dannjjm 4559 22 the the DT cord-023095-4dannjjm 4559 23 hydrolysis hydrolysis NN cord-023095-4dannjjm 4559 24 of of IN cord-023095-4dannjjm 4559 25 GM GM NNP cord-023095-4dannjjm 4559 26 2 2 CD cord-023095-4dannjjm 4559 27 ganglioside ganglioside NN cord-023095-4dannjjm 4559 28 . . . cord-023095-4dannjjm 4560 1 Substitution substitution NN cord-023095-4dannjjm 4560 2 of of IN cord-023095-4dannjjm 4560 3 a a DT cord-023095-4dannjjm 4560 4 lysine lysine NN cord-023095-4dannjjm 4560 5 residue residue NN cord-023095-4dannjjm 4560 6 at at IN cord-023095-4dannjjm 4560 7 this this DT cord-023095-4dannjjm 4560 8 site site NN cord-023095-4dannjjm 4560 9 is be VBZ cord-023095-4dannjjm 4560 10 likely likely JJ cord-023095-4dannjjm 4560 11 to to TO cord-023095-4dannjjm 4560 12 eliminate eliminate VB cord-023095-4dannjjm 4560 13 subunit subunit NN cord-023095-4dannjjm 4560 14 A a DT cord-023095-4dannjjm 4560 15 enzymatic enzymatic JJ cord-023095-4dannjjm 4560 16 activity activity NN cord-023095-4dannjjm 4560 17 . . . cord-023095-4dannjjm 4561 1 The the DT cord-023095-4dannjjm 4561 2 apparently apparently RB cord-023095-4dannjjm 4561 3 normal normal JJ cord-023095-4dannjjm 4561 4 levels level NNS cord-023095-4dannjjm 4561 5 of of IN cord-023095-4dannjjm 4561 6 hexosaminidase hexosaminidase NNP cord-023095-4dannjjm 4561 7 A a DT cord-023095-4dannjjm 4561 8 activity activity NN cord-023095-4dannjjm 4561 9 in in IN cord-023095-4dannjjm 4561 10 affected affect VBN cord-023095-4dannjjm 4561 11 dog dog NN cord-023095-4dannjjm 4561 12 samples sample NNS cord-023095-4dannjjm 4561 13 may may MD cord-023095-4dannjjm 4561 14 be be VB cord-023095-4dannjjm 4561 15 a a DT cord-023095-4dannjjm 4561 16 result result NN cord-023095-4dannjjm 4561 17 of of IN cord-023095-4dannjjm 4561 18 b b NN cord-023095-4dannjjm 4561 19 subunit subunit NN cord-023095-4dannjjm 4561 20 overexpression overexpression NN cord-023095-4dannjjm 4561 21 . . . cord-023095-4dannjjm 4562 1 Human human JJ cord-023095-4dannjjm 4562 2 Hex Hex NNP cord-023095-4dannjjm 4562 3 B B NNP cord-023095-4dannjjm 4562 4 possesses possess VBZ cord-023095-4dannjjm 4562 5 low low JJ cord-023095-4dannjjm 4562 6 levels level NNS cord-023095-4dannjjm 4562 7 activity activity NN cord-023095-4dannjjm 4562 8 against against IN cord-023095-4dannjjm 4562 9 the the DT cord-023095-4dannjjm 4562 10 artificial artificial JJ cord-023095-4dannjjm 4562 11 substrate substrate NN cord-023095-4dannjjm 4562 12 used use VBN cord-023095-4dannjjm 4562 13 to to TO cord-023095-4dannjjm 4562 14 assess assess VB cord-023095-4dannjjm 4562 15 Hex Hex NNP cord-023095-4dannjjm 4562 16 A A NNP cord-023095-4dannjjm 4562 17 activity activity NN cord-023095-4dannjjm 4562 18 , , , cord-023095-4dannjjm 4562 19 but but CC cord-023095-4dannjjm 4562 20 specificity specificity NN cord-023095-4dannjjm 4562 21 of of IN cord-023095-4dannjjm 4562 22 activity activity NN cord-023095-4dannjjm 4562 23 of of IN cord-023095-4dannjjm 4562 24 the the DT cord-023095-4dannjjm 4562 25 canine canine JJ cord-023095-4dannjjm 4562 26 enzyme enzyme NN cord-023095-4dannjjm 4562 27 is be VBZ cord-023095-4dannjjm 4562 28 not not RB cord-023095-4dannjjm 4562 29 known know VBN cord-023095-4dannjjm 4562 30 . . . cord-023095-4dannjjm 4563 1 Previously previously RB cord-023095-4dannjjm 4563 2 presented present VBN cord-023095-4dannjjm 4563 3 at at IN cord-023095-4dannjjm 4563 4 the the DT cord-023095-4dannjjm 4563 5 American American NNP cord-023095-4dannjjm 4563 6 Society Society NNP cord-023095-4dannjjm 4563 7 for for IN cord-023095-4dannjjm 4563 8 Neurochemistry Neurochemistry NNP cord-023095-4dannjjm 4563 9 : : : cord-023095-4dannjjm 4563 10 additional additional JJ cord-023095-4dannjjm 4563 11 data datum NNS cord-023095-4dannjjm 4563 12 in in IN cord-023095-4dannjjm 4563 13 this this DT cord-023095-4dannjjm 4563 14 abstract abstract NN cord-023095-4dannjjm 4563 15 . . . cord-023095-4dannjjm 4564 1 Phenytoin Phenytoin NNP cord-023095-4dannjjm 4564 2 ( ( -LRB- cord-023095-4dannjjm 4564 3 PHT PHT NNP cord-023095-4dannjjm 4564 4 ) ) -RRB- cord-023095-4dannjjm 4564 5 is be VBZ cord-023095-4dannjjm 4564 6 the the DT cord-023095-4dannjjm 4564 7 intravenous intravenous JJ cord-023095-4dannjjm 4564 8 drug drug NN cord-023095-4dannjjm 4564 9 of of IN cord-023095-4dannjjm 4564 10 choice choice NN cord-023095-4dannjjm 4564 11 in in IN cord-023095-4dannjjm 4564 12 humans human NNS cord-023095-4dannjjm 4564 13 for for IN cord-023095-4dannjjm 4564 14 seizure seizure NN cord-023095-4dannjjm 4564 15 emergencies emergency NNS cord-023095-4dannjjm 4564 16 following follow VBG cord-023095-4dannjjm 4564 17 benzodiazapines benzodiazapine NNS cord-023095-4dannjjm 4564 18 . . . cord-023095-4dannjjm 4565 1 IV IV NNP cord-023095-4dannjjm 4565 2 fosphenytoin fosphenytoin NNP cord-023095-4dannjjm 4565 3 ( ( -LRB- cord-023095-4dannjjm 4565 4 FOS FOS NNP cord-023095-4dannjjm 4565 5 ) ) -RRB- cord-023095-4dannjjm 4565 6 is be VBZ cord-023095-4dannjjm 4565 7 a a DT cord-023095-4dannjjm 4565 8 PHT PHT NNP cord-023095-4dannjjm 4565 9 pro pro JJ cord-023095-4dannjjm 4565 10 - - JJ cord-023095-4dannjjm 4565 11 drug drug JJ cord-023095-4dannjjm 4565 12 which which WDT cord-023095-4dannjjm 4565 13 causes cause VBZ cord-023095-4dannjjm 4565 14 less less JJR cord-023095-4dannjjm 4565 15 administration administration NN cord-023095-4dannjjm 4565 16 related relate VBD cord-023095-4dannjjm 4565 17 adverse adverse JJ cord-023095-4dannjjm 4565 18 events event NNS cord-023095-4dannjjm 4565 19 . . . cord-023095-4dannjjm 4566 1 While while IN cord-023095-4dannjjm 4566 2 the the DT cord-023095-4dannjjm 4566 3 short short JJ cord-023095-4dannjjm 4566 4 half half JJ cord-023095-4dannjjm 4566 5 - - HYPH cord-023095-4dannjjm 4566 6 life life NN cord-023095-4dannjjm 4566 7 of of IN cord-023095-4dannjjm 4566 8 PHT PHT NNP cord-023095-4dannjjm 4566 9 is be VBZ cord-023095-4dannjjm 4566 10 not not RB cord-023095-4dannjjm 4566 11 suitable suitable JJ cord-023095-4dannjjm 4566 12 for for IN cord-023095-4dannjjm 4566 13 chronic chronic JJ cord-023095-4dannjjm 4566 14 oral oral JJ cord-023095-4dannjjm 4566 15 therapy therapy NN cord-023095-4dannjjm 4566 16 in in IN cord-023095-4dannjjm 4566 17 dogs dog NNS cord-023095-4dannjjm 4566 18 , , , cord-023095-4dannjjm 4566 19 IV IV NNP cord-023095-4dannjjm 4566 20 FOS FOS NNP cord-023095-4dannjjm 4566 21 has have VBZ cord-023095-4dannjjm 4566 22 not not RB cord-023095-4dannjjm 4566 23 been be VBN cord-023095-4dannjjm 4566 24 studied study VBN cord-023095-4dannjjm 4566 25 . . . cord-023095-4dannjjm 4567 1 Two two CD cord-023095-4dannjjm 4567 2 dogs dog NNS cord-023095-4dannjjm 4567 3 received receive VBD cord-023095-4dannjjm 4567 4 15 15 CD cord-023095-4dannjjm 4567 5 mg mg NN cord-023095-4dannjjm 4567 6 / / SYM cord-023095-4dannjjm 4567 7 kg kg NN cord-023095-4dannjjm 4567 8 phenytoin phenytoin NN cord-023095-4dannjjm 4567 9 equivalent equivalent NN cord-023095-4dannjjm 4567 10 ( ( -LRB- cord-023095-4dannjjm 4567 11 PE PE NNP cord-023095-4dannjjm 4567 12 ) ) -RRB- cord-023095-4dannjjm 4567 13 and and CC cord-023095-4dannjjm 4567 14 two two CD cord-023095-4dannjjm 4567 15 dogs dog NNS cord-023095-4dannjjm 4567 16 received receive VBD cord-023095-4dannjjm 4567 17 25 25 CD cord-023095-4dannjjm 4567 18 mg mg NNP cord-023095-4dannjjm 4567 19 / / SYM cord-023095-4dannjjm 4567 20 kg kg NNP cord-023095-4dannjjm 4567 21 PE PE NNP cord-023095-4dannjjm 4567 22 of of IN cord-023095-4dannjjm 4567 23 fosphenytoin fosphenytoin NNP cord-023095-4dannjjm 4567 24 intravenously intravenously RB cord-023095-4dannjjm 4567 25 at at IN cord-023095-4dannjjm 4567 26 a a DT cord-023095-4dannjjm 4567 27 rate rate NN cord-023095-4dannjjm 4567 28 of of IN cord-023095-4dannjjm 4567 29 50 50 CD cord-023095-4dannjjm 4567 30 mg mg NNP cord-023095-4dannjjm 4567 31 PE PE NNP cord-023095-4dannjjm 4567 32 / / SYM cord-023095-4dannjjm 4567 33 min min NN cord-023095-4dannjjm 4567 34 . . . cord-023095-4dannjjm 4568 1 Blood blood NN cord-023095-4dannjjm 4568 2 for for IN cord-023095-4dannjjm 4568 3 plasma plasma NN cord-023095-4dannjjm 4568 4 levels level NNS cord-023095-4dannjjm 4568 5 were be VBD cord-023095-4dannjjm 4568 6 drawn draw VBN cord-023095-4dannjjm 4568 7 at at IN cord-023095-4dannjjm 4568 8 10 10 CD cord-023095-4dannjjm 4568 9 time time NN cord-023095-4dannjjm 4568 10 - - HYPH cord-023095-4dannjjm 4568 11 points point NNS cord-023095-4dannjjm 4568 12 over over IN cord-023095-4dannjjm 4568 13 12 12 CD cord-023095-4dannjjm 4568 14 hours hour NNS cord-023095-4dannjjm 4568 15 ; ; : cord-023095-4dannjjm 4568 16 total total JJ cord-023095-4dannjjm 4568 17 and and CC cord-023095-4dannjjm 4568 18 unbound unbound JJ cord-023095-4dannjjm 4568 19 drug drug NN cord-023095-4dannjjm 4568 20 levels level NNS cord-023095-4dannjjm 4568 21 were be VBD cord-023095-4dannjjm 4568 22 measured measure VBN cord-023095-4dannjjm 4568 23 by by IN cord-023095-4dannjjm 4568 24 HPLC HPLC NNP cord-023095-4dannjjm 4568 25 . . . cord-023095-4dannjjm 4569 1 Vital vital JJ cord-023095-4dannjjm 4569 2 signs sign NNS cord-023095-4dannjjm 4569 3 including include VBG cord-023095-4dannjjm 4569 4 EKG ekg NN cord-023095-4dannjjm 4569 5 , , , cord-023095-4dannjjm 4569 6 blood blood NN cord-023095-4dannjjm 4569 7 pressure pressure NN cord-023095-4dannjjm 4569 8 , , , cord-023095-4dannjjm 4569 9 and and CC cord-023095-4dannjjm 4569 10 neurological neurological JJ cord-023095-4dannjjm 4569 11 examination examination NN cord-023095-4dannjjm 4569 12 were be VBD cord-023095-4dannjjm 4569 13 monitored monitor VBN cord-023095-4dannjjm 4569 14 . . . cord-023095-4dannjjm 4570 1 The the DT cord-023095-4dannjjm 4570 2 half half JJ cord-023095-4dannjjm 4570 3 - - HYPH cord-023095-4dannjjm 4570 4 life life NN cord-023095-4dannjjm 4570 5 of of IN cord-023095-4dannjjm 4570 6 metabolism metabolism NN cord-023095-4dannjjm 4570 7 of of IN cord-023095-4dannjjm 4570 8 FOS FOS NNP cord-023095-4dannjjm 4570 9 to to IN cord-023095-4dannjjm 4570 10 PHT PHT NNP cord-023095-4dannjjm 4570 11 was be VBD cord-023095-4dannjjm 4570 12 $ $ $ cord-023095-4dannjjm 4570 13 10 10 CD cord-023095-4dannjjm 4570 14 min min NN cord-023095-4dannjjm 4570 15 , , , cord-023095-4dannjjm 4570 16 with with IN cord-023095-4dannjjm 4570 17 4 4 CD cord-023095-4dannjjm 4570 18 80 80 CD cord-023095-4dannjjm 4570 19 % % NN cord-023095-4dannjjm 4570 20 of of IN cord-023095-4dannjjm 4570 21 FOS FOS NNP cord-023095-4dannjjm 4570 22 metabolized metabolize VBN cord-023095-4dannjjm 4570 23 to to IN cord-023095-4dannjjm 4570 24 PHT PHT NNP cord-023095-4dannjjm 4570 25 by by IN cord-023095-4dannjjm 4570 26 30 30 CD cord-023095-4dannjjm 4570 27 minutes minute NNS cord-023095-4dannjjm 4570 28 . . . cord-023095-4dannjjm 4571 1 Eighty eighty CD cord-023095-4dannjjm 4571 2 to to TO cord-023095-4dannjjm 4571 3 84 84 CD cord-023095-4dannjjm 4571 4 % % NN cord-023095-4dannjjm 4571 5 of of IN cord-023095-4dannjjm 4571 6 PHT PHT NNP cord-023095-4dannjjm 4571 7 was be VBD cord-023095-4dannjjm 4571 8 protein protein NN cord-023095-4dannjjm 4571 9 - - HYPH cord-023095-4dannjjm 4571 10 bound bind VBN cord-023095-4dannjjm 4571 11 during during IN cord-023095-4dannjjm 4571 12 the the DT cord-023095-4dannjjm 4571 13 first first JJ cord-023095-4dannjjm 4571 14 15 15 CD cord-023095-4dannjjm 4571 15 minutes minute NNS cord-023095-4dannjjm 4571 16 after after IN cord-023095-4dannjjm 4571 17 dosing dose VBG cord-023095-4dannjjm 4571 18 , , , cord-023095-4dannjjm 4571 19 compared compare VBN cord-023095-4dannjjm 4571 20 to to IN cord-023095-4dannjjm 4571 21 90 90 CD cord-023095-4dannjjm 4571 22 - - SYM cord-023095-4dannjjm 4571 23 95 95 CD cord-023095-4dannjjm 4571 24 % % NN cord-023095-4dannjjm 4571 25 in in IN cord-023095-4dannjjm 4571 26 humans human NNS cord-023095-4dannjjm 4571 27 . . . cord-023095-4dannjjm 4572 1 The the DT cord-023095-4dannjjm 4572 2 elimination elimination NN cord-023095-4dannjjm 4572 3 half half JJ cord-023095-4dannjjm 4572 4 - - HYPH cord-023095-4dannjjm 4572 5 life life NN cord-023095-4dannjjm 4572 6 for for IN cord-023095-4dannjjm 4572 7 total total JJ cord-023095-4dannjjm 4572 8 PHT PHT NNP cord-023095-4dannjjm 4572 9 ranged range VBD cord-023095-4dannjjm 4572 10 from from IN cord-023095-4dannjjm 4572 11 2.8 2.8 CD cord-023095-4dannjjm 4572 12 - - SYM cord-023095-4dannjjm 4572 13 3.5 3.5 CD cord-023095-4dannjjm 4572 14 hours hour NNS cord-023095-4dannjjm 4572 15 and and CC cord-023095-4dannjjm 4572 16 for for IN cord-023095-4dannjjm 4572 17 unbound unbound JJ cord-023095-4dannjjm 4572 18 PHT PHT NNP cord-023095-4dannjjm 4572 19 ranged range VBD cord-023095-4dannjjm 4572 20 from from IN cord-023095-4dannjjm 4572 21 1.9 1.9 CD cord-023095-4dannjjm 4572 22 - - SYM cord-023095-4dannjjm 4572 23 5.4 5.4 CD cord-023095-4dannjjm 4572 24 hours hour NNS cord-023095-4dannjjm 4572 25 . . . cord-023095-4dannjjm 4573 1 Dogs dog NNS cord-023095-4dannjjm 4573 2 receiving receive VBG cord-023095-4dannjjm 4573 3 15 15 CD cord-023095-4dannjjm 4573 4 mg mg NNP cord-023095-4dannjjm 4573 5 / / SYM cord-023095-4dannjjm 4573 6 kg kg NNP cord-023095-4dannjjm 4573 7 PE PE NNP cord-023095-4dannjjm 4573 8 intravenously intravenously RB cord-023095-4dannjjm 4573 9 achieved achieve VBD cord-023095-4dannjjm 4573 10 unbound unbound JJ cord-023095-4dannjjm 4573 11 PHT pht NN cord-023095-4dannjjm 4573 12 plasma plasma NN cord-023095-4dannjjm 4573 13 maximum maximum JJ cord-023095-4dannjjm 4573 14 concentrations concentration NNS cord-023095-4dannjjm 4573 15 of of IN cord-023095-4dannjjm 4573 16 2.2 2.2 CD cord-023095-4dannjjm 4573 17 - - HYPH cord-023095-4dannjjm 4573 18 2.4ug 2.4ug CD cord-023095-4dannjjm 4573 19 / / SYM cord-023095-4dannjjm 4573 20 ml ml NN cord-023095-4dannjjm 4573 21 at at IN cord-023095-4dannjjm 4573 22 5 5 CD cord-023095-4dannjjm 4573 23 minutes minute NNS cord-023095-4dannjjm 4573 24 , , , cord-023095-4dannjjm 4573 25 consistent consistent JJ cord-023095-4dannjjm 4573 26 with with IN cord-023095-4dannjjm 4573 27 human human JJ cord-023095-4dannjjm 4573 28 loading loading NN cord-023095-4dannjjm 4573 29 dose dose NN cord-023095-4dannjjm 4573 30 levels level NNS cord-023095-4dannjjm 4573 31 . . . cord-023095-4dannjjm 4574 1 Adverse adverse JJ cord-023095-4dannjjm 4574 2 events event NNS cord-023095-4dannjjm 4574 3 observed observe VBN cord-023095-4dannjjm 4574 4 in in IN cord-023095-4dannjjm 4574 5 some some DT cord-023095-4dannjjm 4574 6 dogs dog NNS cord-023095-4dannjjm 4574 7 included include VBD cord-023095-4dannjjm 4574 8 vomiting vomit VBG cord-023095-4dannjjm 4574 9 , , , cord-023095-4dannjjm 4574 10 mild mild JJ cord-023095-4dannjjm 4574 11 ataxia ataxia NN cord-023095-4dannjjm 4574 12 , , , cord-023095-4dannjjm 4574 13 and and CC cord-023095-4dannjjm 4574 14 short short JJ cord-023095-4dannjjm 4574 15 lived live VBN cord-023095-4dannjjm 4574 16 tremors tremor NNS cord-023095-4dannjjm 4574 17 , , , cord-023095-4dannjjm 4574 18 the the DT cord-023095-4dannjjm 4574 19 severity severity NN cord-023095-4dannjjm 4574 20 of of IN cord-023095-4dannjjm 4574 21 which which WDT cord-023095-4dannjjm 4574 22 appeared appear VBD cord-023095-4dannjjm 4574 23 dose dose RB cord-023095-4dannjjm 4574 24 dependent dependent JJ cord-023095-4dannjjm 4574 25 . . . cord-023095-4dannjjm 4575 1 All all DT cord-023095-4dannjjm 4575 2 dogs dog NNS cord-023095-4dannjjm 4575 3 were be VBD cord-023095-4dannjjm 4575 4 clinically clinically RB cord-023095-4dannjjm 4575 5 normal normal JJ cord-023095-4dannjjm 4575 6 within within IN cord-023095-4dannjjm 4575 7 30 30 CD cord-023095-4dannjjm 4575 8 minutes minute NNS cord-023095-4dannjjm 4575 9 of of IN cord-023095-4dannjjm 4575 10 all all DT cord-023095-4dannjjm 4575 11 doses dose NNS cord-023095-4dannjjm 4575 12 . . . cord-023095-4dannjjm 4576 1 A a DT cord-023095-4dannjjm 4576 2 15 15 CD cord-023095-4dannjjm 4576 3 mg mg NN cord-023095-4dannjjm 4576 4 / / SYM cord-023095-4dannjjm 4576 5 kg kg NNP cord-023095-4dannjjm 4576 6 PE PE NNP cord-023095-4dannjjm 4576 7 dose dose NN cord-023095-4dannjjm 4576 8 of of IN cord-023095-4dannjjm 4576 9 IV IV NNP cord-023095-4dannjjm 4576 10 FOS FOS NNP cord-023095-4dannjjm 4576 11 appears appear VBZ cord-023095-4dannjjm 4576 12 adequate adequate JJ cord-023095-4dannjjm 4576 13 for for IN cord-023095-4dannjjm 4576 14 production production NN cord-023095-4dannjjm 4576 15 of of IN cord-023095-4dannjjm 4576 16 PHT PHT NNP cord-023095-4dannjjm 4576 17 levels level NNS cord-023095-4dannjjm 4576 18 predicted predict VBN cord-023095-4dannjjm 4576 19 to to TO cord-023095-4dannjjm 4576 20 be be VB cord-023095-4dannjjm 4576 21 effective effective JJ cord-023095-4dannjjm 4576 22 for for IN cord-023095-4dannjjm 4576 23 the the DT cord-023095-4dannjjm 4576 24 treatment treatment NN cord-023095-4dannjjm 4576 25 of of IN cord-023095-4dannjjm 4576 26 canine canine JJ cord-023095-4dannjjm 4576 27 seizure seizure NN cord-023095-4dannjjm 4576 28 emergencies emergency NNS cord-023095-4dannjjm 4576 29 . . . cord-023095-4dannjjm 4577 1 Further further JJ cord-023095-4dannjjm 4577 2 studies study NNS cord-023095-4dannjjm 4577 3 in in IN cord-023095-4dannjjm 4577 4 clinical clinical JJ cord-023095-4dannjjm 4577 5 canine canine JJ cord-023095-4dannjjm 4577 6 patients patient NNS cord-023095-4dannjjm 4577 7 are be VBP cord-023095-4dannjjm 4577 8 warranted warrant VBN cord-023095-4dannjjm 4577 9 . . . cord-023095-4dannjjm 4578 1 Acquired acquire VBN cord-023095-4dannjjm 4578 2 myasthenia myasthenia NN cord-023095-4dannjjm 4578 3 gravis gravis NN cord-023095-4dannjjm 4578 4 ( ( -LRB- cord-023095-4dannjjm 4578 5 MG MG NNP cord-023095-4dannjjm 4578 6 ) ) -RRB- cord-023095-4dannjjm 4578 7 is be VBZ cord-023095-4dannjjm 4578 8 caused cause VBN cord-023095-4dannjjm 4578 9 by by IN cord-023095-4dannjjm 4578 10 antibodymediated antibodymediated JJ cord-023095-4dannjjm 4578 11 inactivation inactivation NN cord-023095-4dannjjm 4578 12 of of IN cord-023095-4dannjjm 4578 13 the the DT cord-023095-4dannjjm 4578 14 acetylcholine acetylcholine NN cord-023095-4dannjjm 4578 15 receptor receptor NN cord-023095-4dannjjm 4578 16 on on IN cord-023095-4dannjjm 4578 17 the the DT cord-023095-4dannjjm 4578 18 neuromuscular neuromuscular JJ cord-023095-4dannjjm 4578 19 endplate endplate NN cord-023095-4dannjjm 4578 20 causing cause VBG cord-023095-4dannjjm 4578 21 focal focal JJ cord-023095-4dannjjm 4578 22 , , , cord-023095-4dannjjm 4578 23 regional regional JJ cord-023095-4dannjjm 4578 24 or or CC cord-023095-4dannjjm 4578 25 generalized generalized JJ cord-023095-4dannjjm 4578 26 muscle muscle NN cord-023095-4dannjjm 4578 27 weakness weakness NN cord-023095-4dannjjm 4578 28 . . . cord-023095-4dannjjm 4579 1 Many many JJ cord-023095-4dannjjm 4579 2 medical medical JJ cord-023095-4dannjjm 4579 3 treatments treatment NNS cord-023095-4dannjjm 4579 4 have have VBP cord-023095-4dannjjm 4579 5 been be VBN cord-023095-4dannjjm 4579 6 reported report VBN cord-023095-4dannjjm 4579 7 ; ; : cord-023095-4dannjjm 4579 8 however however RB cord-023095-4dannjjm 4579 9 , , , cord-023095-4dannjjm 4579 10 responses response NNS cord-023095-4dannjjm 4579 11 to to IN cord-023095-4dannjjm 4579 12 therapy therapy NN cord-023095-4dannjjm 4579 13 and and CC cord-023095-4dannjjm 4579 14 outcomes outcome NNS cord-023095-4dannjjm 4579 15 are be VBP cord-023095-4dannjjm 4579 16 unpredictable unpredictable JJ cord-023095-4dannjjm 4579 17 and and CC cord-023095-4dannjjm 4579 18 death death NN cord-023095-4dannjjm 4579 19 often often RB cord-023095-4dannjjm 4579 20 results result VBZ cord-023095-4dannjjm 4579 21 from from IN cord-023095-4dannjjm 4579 22 aspiration aspiration NN cord-023095-4dannjjm 4579 23 pneumonia pneumonia NN cord-023095-4dannjjm 4579 24 . . . cord-023095-4dannjjm 4580 1 Therapeutic therapeutic JJ cord-023095-4dannjjm 4580 2 apheresis apheresis NN cord-023095-4dannjjm 4580 3 is be VBZ cord-023095-4dannjjm 4580 4 an an DT cord-023095-4dannjjm 4580 5 extracorporeal extracorporeal JJ cord-023095-4dannjjm 4580 6 procedure procedure NN cord-023095-4dannjjm 4580 7 that that WDT cord-023095-4dannjjm 4580 8 separates separate VBZ cord-023095-4dannjjm 4580 9 blood blood NN cord-023095-4dannjjm 4580 10 into into IN cord-023095-4dannjjm 4580 11 its -PRON- PRP$ cord-023095-4dannjjm 4580 12 components component NNS cord-023095-4dannjjm 4580 13 for for IN cord-023095-4dannjjm 4580 14 removal removal NN cord-023095-4dannjjm 4580 15 or or CC cord-023095-4dannjjm 4580 16 specific specific JJ cord-023095-4dannjjm 4580 17 alteration alteration NN cord-023095-4dannjjm 4580 18 prior prior RB cord-023095-4dannjjm 4580 19 to to TO cord-023095-4dannjjm 4580 20 return return VB cord-023095-4dannjjm 4580 21 to to IN cord-023095-4dannjjm 4580 22 the the DT cord-023095-4dannjjm 4580 23 patient patient NN cord-023095-4dannjjm 4580 24 . . . cord-023095-4dannjjm 4581 1 Therapeutic therapeutic JJ cord-023095-4dannjjm 4581 2 plasma plasma NN cord-023095-4dannjjm 4581 3 exchange exchange NN cord-023095-4dannjjm 4581 4 ( ( -LRB- cord-023095-4dannjjm 4581 5 TPE TPE NNP cord-023095-4dannjjm 4581 6 ) ) -RRB- cord-023095-4dannjjm 4581 7 is be VBZ cord-023095-4dannjjm 4581 8 an an DT cord-023095-4dannjjm 4581 9 apheresis apheresis NN cord-023095-4dannjjm 4581 10 treatment treatment NN cord-023095-4dannjjm 4581 11 in in IN cord-023095-4dannjjm 4581 12 which which WDT cord-023095-4dannjjm 4581 13 plasma plasma NN cord-023095-4dannjjm 4581 14 ( ( -LRB- cord-023095-4dannjjm 4581 15 containing contain VBG cord-023095-4dannjjm 4581 16 pathologic pathologic JJ cord-023095-4dannjjm 4581 17 antibodies antibody NNS cord-023095-4dannjjm 4581 18 ) ) -RRB- cord-023095-4dannjjm 4581 19 is be VBZ cord-023095-4dannjjm 4581 20 removed remove VBN cord-023095-4dannjjm 4581 21 and and CC cord-023095-4dannjjm 4581 22 exchanged exchange VBN cord-023095-4dannjjm 4581 23 with with IN cord-023095-4dannjjm 4581 24 donor donor NN cord-023095-4dannjjm 4581 25 plasma plasma NN cord-023095-4dannjjm 4581 26 . . . cord-023095-4dannjjm 4582 1 TPE TPE NNP cord-023095-4dannjjm 4582 2 is be VBZ cord-023095-4dannjjm 4582 3 used use VBN cord-023095-4dannjjm 4582 4 routinely routinely RB cord-023095-4dannjjm 4582 5 to to TO cord-023095-4dannjjm 4582 6 treat treat VB cord-023095-4dannjjm 4582 7 MG MG NNP cord-023095-4dannjjm 4582 8 in in IN cord-023095-4dannjjm 4582 9 human human JJ cord-023095-4dannjjm 4582 10 patients patient NNS cord-023095-4dannjjm 4582 11 with with IN cord-023095-4dannjjm 4582 12 severe severe JJ cord-023095-4dannjjm 4582 13 disease disease NN cord-023095-4dannjjm 4582 14 or or CC cord-023095-4dannjjm 4582 15 disease disease NN cord-023095-4dannjjm 4582 16 unresponsive unresponsive JJ cord-023095-4dannjjm 4582 17 to to IN cord-023095-4dannjjm 4582 18 conventional conventional JJ cord-023095-4dannjjm 4582 19 therapy therapy NN cord-023095-4dannjjm 4582 20 . . . cord-023095-4dannjjm 4583 1 We -PRON- PRP cord-023095-4dannjjm 4583 2 report report VBP cord-023095-4dannjjm 4583 3 the the DT cord-023095-4dannjjm 4583 4 successful successful JJ cord-023095-4dannjjm 4583 5 use use NN cord-023095-4dannjjm 4583 6 of of IN cord-023095-4dannjjm 4583 7 TPE TPE NNP cord-023095-4dannjjm 4583 8 to to TO cord-023095-4dannjjm 4583 9 treat treat VB cord-023095-4dannjjm 4583 10 2 2 CD cord-023095-4dannjjm 4583 11 large large JJ cord-023095-4dannjjm 4583 12 breed breed NN cord-023095-4dannjjm 4583 13 dogs dog NNS cord-023095-4dannjjm 4583 14 with with IN cord-023095-4dannjjm 4583 15 confirmed confirm VBN cord-023095-4dannjjm 4583 16 MG MG NNP cord-023095-4dannjjm 4583 17 ( ( -LRB- cord-023095-4dannjjm 4583 18 aceytlcholine aceytlcholine NNP cord-023095-4dannjjm 4583 19 receptor receptor NNP cord-023095-4dannjjm 4583 20 antibody antibody NN cord-023095-4dannjjm 4583 21 concentration concentration NN cord-023095-4dannjjm 4583 22 : : : cord-023095-4dannjjm 4583 23 3.05 3.05 CD cord-023095-4dannjjm 4583 24 and and CC cord-023095-4dannjjm 4583 25 3.32 3.32 CD cord-023095-4dannjjm 4583 26 nM nM NNP cord-023095-4dannjjm 4583 27 / / SYM cord-023095-4dannjjm 4583 28 L L NNP cord-023095-4dannjjm 4583 29 , , , cord-023095-4dannjjm 4583 30 respectively respectively RB cord-023095-4dannjjm 4583 31 ; ; : cord-023095-4dannjjm 4583 32 normal normal JJ cord-023095-4dannjjm 4583 33 concentration concentration NN cord-023095-4dannjjm 4583 34 : : : cord-023095-4dannjjm 4583 35 o o LS cord-023095-4dannjjm 4583 36 0.6 0.6 CD cord-023095-4dannjjm 4583 37 nM/ nM/ NNP cord-023095-4dannjjm 4583 38 L L NNP cord-023095-4dannjjm 4583 39 ) ) -RRB- cord-023095-4dannjjm 4583 40 that that WDT cord-023095-4dannjjm 4583 41 was be VBD cord-023095-4dannjjm 4583 42 severe severe JJ cord-023095-4dannjjm 4583 43 and and CC cord-023095-4dannjjm 4583 44 not not RB cord-023095-4dannjjm 4583 45 adequately adequately RB cord-023095-4dannjjm 4583 46 responsive responsive JJ cord-023095-4dannjjm 4583 47 to to IN cord-023095-4dannjjm 4583 48 traditional traditional JJ cord-023095-4dannjjm 4583 49 therapies therapy NNS cord-023095-4dannjjm 4583 50 . . . cord-023095-4dannjjm 4584 1 Both both DT cord-023095-4dannjjm 4584 2 dogs dog NNS cord-023095-4dannjjm 4584 3 were be VBD cord-023095-4dannjjm 4584 4 non non JJ cord-023095-4dannjjm 4584 5 - - JJ cord-023095-4dannjjm 4584 6 ambulatory ambulatory JJ cord-023095-4dannjjm 4584 7 , , , cord-023095-4dannjjm 4584 8 recumbent recumbent JJ cord-023095-4dannjjm 4584 9 , , , cord-023095-4dannjjm 4584 10 and and CC cord-023095-4dannjjm 4584 11 demonstrated demonstrate VBD cord-023095-4dannjjm 4584 12 megaesophagus megaesophagus NNP cord-023095-4dannjjm 4584 13 and and CC cord-023095-4dannjjm 4584 14 aspiration aspiration NN cord-023095-4dannjjm 4584 15 pneumonia pneumonia NN cord-023095-4dannjjm 4584 16 . . . cord-023095-4dannjjm 4585 1 Three three CD cord-023095-4dannjjm 4585 2 TPE TPE NNP cord-023095-4dannjjm 4585 3 treatments treatment NNS cord-023095-4dannjjm 4585 4 ( ( -LRB- cord-023095-4dannjjm 4585 5 1 1 CD cord-023095-4dannjjm 4585 6 plasma plasma NN cord-023095-4dannjjm 4585 7 exchange exchange NN cord-023095-4dannjjm 4585 8 each each DT cord-023095-4dannjjm 4585 9 ) ) -RRB- cord-023095-4dannjjm 4585 10 were be VBD cord-023095-4dannjjm 4585 11 performed perform VBN cord-023095-4dannjjm 4585 12 over over IN cord-023095-4dannjjm 4585 13 5 5 CD cord-023095-4dannjjm 4585 14 and and CC cord-023095-4dannjjm 4585 15 7 7 CD cord-023095-4dannjjm 4585 16 days day NNS cord-023095-4dannjjm 4585 17 , , , cord-023095-4dannjjm 4585 18 respectively respectively RB cord-023095-4dannjjm 4585 19 , , , cord-023095-4dannjjm 4585 20 in in IN cord-023095-4dannjjm 4585 21 each each DT cord-023095-4dannjjm 4585 22 dog dog NN cord-023095-4dannjjm 4585 23 without without IN cord-023095-4dannjjm 4585 24 complication complication NN cord-023095-4dannjjm 4585 25 . . . cord-023095-4dannjjm 4586 1 Both both DT cord-023095-4dannjjm 4586 2 dogs dog NNS cord-023095-4dannjjm 4586 3 became become VBD cord-023095-4dannjjm 4586 4 ambulatory ambulatory JJ cord-023095-4dannjjm 4586 5 within within IN cord-023095-4dannjjm 4586 6 3 3 CD cord-023095-4dannjjm 4586 7 days day NNS cord-023095-4dannjjm 4586 8 of of IN cord-023095-4dannjjm 4586 9 starting start VBG cord-023095-4dannjjm 4586 10 TPE TPE NNP cord-023095-4dannjjm 4586 11 treatment treatment NN cord-023095-4dannjjm 4586 12 with with IN cord-023095-4dannjjm 4586 13 subsequent subsequent JJ cord-023095-4dannjjm 4586 14 resolution resolution NN cord-023095-4dannjjm 4586 15 of of IN cord-023095-4dannjjm 4586 16 regurgitation regurgitation NN cord-023095-4dannjjm 4586 17 and and CC cord-023095-4dannjjm 4586 18 megaesophagus megaesophagus NNP cord-023095-4dannjjm 4586 19 . . . cord-023095-4dannjjm 4587 1 Pyridostigmine Pyridostigmine NNP cord-023095-4dannjjm 4587 2 was be VBD cord-023095-4dannjjm 4587 3 continued continue VBN cord-023095-4dannjjm 4587 4 during during IN cord-023095-4dannjjm 4587 5 TPE TPE NNP cord-023095-4dannjjm 4587 6 sessions session NNS cord-023095-4dannjjm 4587 7 and and CC cord-023095-4dannjjm 4587 8 discontinued discontinue VBD cord-023095-4dannjjm 4587 9 in in IN cord-023095-4dannjjm 4587 10 both both DT cord-023095-4dannjjm 4587 11 dogs dog NNS cord-023095-4dannjjm 4587 12 within within IN cord-023095-4dannjjm 4587 13 3 3 CD cord-023095-4dannjjm 4587 14 - - SYM cord-023095-4dannjjm 4587 15 6 6 CD cord-023095-4dannjjm 4587 16 months month NNS cord-023095-4dannjjm 4587 17 . . . cord-023095-4dannjjm 4588 1 Both both DT cord-023095-4dannjjm 4588 2 dogs dog NNS cord-023095-4dannjjm 4588 3 remain remain VBP cord-023095-4dannjjm 4588 4 asymptomatic asymptomatic JJ cord-023095-4dannjjm 4588 5 and and CC cord-023095-4dannjjm 4588 6 have have VBP cord-023095-4dannjjm 4588 7 had have VBN cord-023095-4dannjjm 4588 8 no no DT cord-023095-4dannjjm 4588 9 recurrence recurrence NN cord-023095-4dannjjm 4588 10 of of IN cord-023095-4dannjjm 4588 11 MG MG NNP cord-023095-4dannjjm 4588 12 during during IN cord-023095-4dannjjm 4588 13 16 16 CD cord-023095-4dannjjm 4588 14 and and CC cord-023095-4dannjjm 4588 15 4 4 CD cord-023095-4dannjjm 4588 16 months month NNS cord-023095-4dannjjm 4588 17 of of IN cord-023095-4dannjjm 4588 18 follow follow NN cord-023095-4dannjjm 4588 19 - - HYPH cord-023095-4dannjjm 4588 20 up up NN cord-023095-4dannjjm 4588 21 , , , cord-023095-4dannjjm 4588 22 respectively respectively RB cord-023095-4dannjjm 4588 23 . . . cord-023095-4dannjjm 4589 1 TPE TPE NNP cord-023095-4dannjjm 4589 2 is be VBZ cord-023095-4dannjjm 4589 3 a a DT cord-023095-4dannjjm 4589 4 viable viable JJ cord-023095-4dannjjm 4589 5 treatment treatment NN cord-023095-4dannjjm 4589 6 option option NN cord-023095-4dannjjm 4589 7 for for IN cord-023095-4dannjjm 4589 8 dogs dog NNS cord-023095-4dannjjm 4589 9 with with IN cord-023095-4dannjjm 4589 10 MG MG NNP cord-023095-4dannjjm 4589 11 that that WDT cord-023095-4dannjjm 4589 12 have have VBP cord-023095-4dannjjm 4589 13 severe severe JJ cord-023095-4dannjjm 4589 14 disease disease NN cord-023095-4dannjjm 4589 15 , , , cord-023095-4dannjjm 4589 16 life life NN cord-023095-4dannjjm 4589 17 - - HYPH cord-023095-4dannjjm 4589 18 threatening threaten VBG cord-023095-4dannjjm 4589 19 complications complication NNS cord-023095-4dannjjm 4589 20 or or CC cord-023095-4dannjjm 4589 21 that that WDT cord-023095-4dannjjm 4589 22 remain remain VBP cord-023095-4dannjjm 4589 23 unresponsive unresponsive JJ cord-023095-4dannjjm 4589 24 to to IN cord-023095-4dannjjm 4589 25 traditional traditional JJ cord-023095-4dannjjm 4589 26 therapies therapy NNS cord-023095-4dannjjm 4589 27 . . . cord-023095-4dannjjm 4590 1 TPE TPE NNP cord-023095-4dannjjm 4590 2 may may MD cord-023095-4dannjjm 4590 3 alleviate alleviate VB cord-023095-4dannjjm 4590 4 clinical clinical JJ cord-023095-4dannjjm 4590 5 signs sign NNS cord-023095-4dannjjm 4590 6 more more RBR cord-023095-4dannjjm 4590 7 rapidly rapidly RB cord-023095-4dannjjm 4590 8 , , , cord-023095-4dannjjm 4590 9 and and CC cord-023095-4dannjjm 4590 10 improve improve VB cord-023095-4dannjjm 4590 11 long long JJ cord-023095-4dannjjm 4590 12 - - HYPH cord-023095-4dannjjm 4590 13 term term NN cord-023095-4dannjjm 4590 14 outcomes outcome NNS cord-023095-4dannjjm 4590 15 when when WRB cord-023095-4dannjjm 4590 16 compared compare VBN cord-023095-4dannjjm 4590 17 to to IN cord-023095-4dannjjm 4590 18 historical historical JJ cord-023095-4dannjjm 4590 19 experiences experience NNS cord-023095-4dannjjm 4590 20 in in IN cord-023095-4dannjjm 4590 21 patients patient NNS cord-023095-4dannjjm 4590 22 with with IN cord-023095-4dannjjm 4590 23 comparable comparable JJ cord-023095-4dannjjm 4590 24 disease disease NN cord-023095-4dannjjm 4590 25 . . . cord-023095-4dannjjm 4591 1 Clinical clinical JJ cord-023095-4dannjjm 4591 2 findings finding NNS cord-023095-4dannjjm 4591 3 , , , cord-023095-4dannjjm 4591 4 clinicopathologic clinicopathologic NNP cord-023095-4dannjjm 4591 5 data datum NNS cord-023095-4dannjjm 4591 6 , , , cord-023095-4dannjjm 4591 7 imaging imaging NN cord-023095-4dannjjm 4591 8 features feature NNS cord-023095-4dannjjm 4591 9 , , , cord-023095-4dannjjm 4591 10 and and CC cord-023095-4dannjjm 4591 11 treatment treatment NN cord-023095-4dannjjm 4591 12 of of IN cord-023095-4dannjjm 4591 13 canine canine JJ cord-023095-4dannjjm 4591 14 spinal spinal JJ cord-023095-4dannjjm 4591 15 meningiomas meningiomas NN cord-023095-4dannjjm 4591 16 have have VBP cord-023095-4dannjjm 4591 17 been be VBN cord-023095-4dannjjm 4591 18 described describe VBN cord-023095-4dannjjm 4591 19 in in IN cord-023095-4dannjjm 4591 20 the the DT cord-023095-4dannjjm 4591 21 veterinary veterinary JJ cord-023095-4dannjjm 4591 22 literature literature NN cord-023095-4dannjjm 4591 23 , , , cord-023095-4dannjjm 4591 24 but but CC cord-023095-4dannjjm 4591 25 histological histological JJ cord-023095-4dannjjm 4591 26 characteristics characteristic NNS cord-023095-4dannjjm 4591 27 and and CC cord-023095-4dannjjm 4591 28 tumor tumor NN cord-023095-4dannjjm 4591 29 grading grading NN cord-023095-4dannjjm 4591 30 have have VBP cord-023095-4dannjjm 4591 31 less less RBR cord-023095-4dannjjm 4591 32 commonly commonly RB cord-023095-4dannjjm 4591 33 been be VBN cord-023095-4dannjjm 4591 34 reported report VBN cord-023095-4dannjjm 4591 35 . . . cord-023095-4dannjjm 4592 1 The the DT cord-023095-4dannjjm 4592 2 aims aim NNS cord-023095-4dannjjm 4592 3 of of IN cord-023095-4dannjjm 4592 4 this this DT cord-023095-4dannjjm 4592 5 retrospective retrospective JJ cord-023095-4dannjjm 4592 6 case case NN cord-023095-4dannjjm 4592 7 series series NN cord-023095-4dannjjm 4592 8 were be VBD cord-023095-4dannjjm 4592 9 to to TO cord-023095-4dannjjm 4592 10 describe describe VB cord-023095-4dannjjm 4592 11 the the DT cord-023095-4dannjjm 4592 12 clinical clinical JJ cord-023095-4dannjjm 4592 13 , , , cord-023095-4dannjjm 4592 14 imaging imaging NN cord-023095-4dannjjm 4592 15 , , , cord-023095-4dannjjm 4592 16 and and CC cord-023095-4dannjjm 4592 17 histologic histologic JJ cord-023095-4dannjjm 4592 18 features feature NNS cord-023095-4dannjjm 4592 19 of of IN cord-023095-4dannjjm 4592 20 seven seven CD cord-023095-4dannjjm 4592 21 canine canine JJ cord-023095-4dannjjm 4592 22 spinal spinal JJ cord-023095-4dannjjm 4592 23 meningiomas meningiomas NN cord-023095-4dannjjm 4592 24 including include VBG cord-023095-4dannjjm 4592 25 a a DT cord-023095-4dannjjm 4592 26 cervical cervical JJ cord-023095-4dannjjm 4592 27 spinal spinal JJ cord-023095-4dannjjm 4592 28 cystic cystic JJ cord-023095-4dannjjm 4592 29 meningioma meningioma NN cord-023095-4dannjjm 4592 30 that that WDT cord-023095-4dannjjm 4592 31 had have VBD cord-023095-4dannjjm 4592 32 imaging image VBG cord-023095-4dannjjm 4592 33 and and CC cord-023095-4dannjjm 4592 34 intraoperative intraoperative JJ cord-023095-4dannjjm 4592 35 features feature NNS cord-023095-4dannjjm 4592 36 of of IN cord-023095-4dannjjm 4592 37 a a DT cord-023095-4dannjjm 4592 38 subarachnoid subarachnoid NN cord-023095-4dannjjm 4592 39 cyst cyst NN cord-023095-4dannjjm 4592 40 . . . cord-023095-4dannjjm 4593 1 Medical medical JJ cord-023095-4dannjjm 4593 2 records record NNS cord-023095-4dannjjm 4593 3 from from IN cord-023095-4dannjjm 4593 4 dogs dog NNS cord-023095-4dannjjm 4593 5 with with IN cord-023095-4dannjjm 4593 6 a a DT cord-023095-4dannjjm 4593 7 histopathological histopathological JJ cord-023095-4dannjjm 4593 8 diagnosis diagnosis NN cord-023095-4dannjjm 4593 9 of of IN cord-023095-4dannjjm 4593 10 spinal spinal JJ cord-023095-4dannjjm 4593 11 cord cord NN cord-023095-4dannjjm 4593 12 meningioma meningioma NN cord-023095-4dannjjm 4593 13 presented present VBN cord-023095-4dannjjm 4593 14 to to IN cord-023095-4dannjjm 4593 15 the the DT cord-023095-4dannjjm 4593 16 Veterinary Veterinary NNP cord-023095-4dannjjm 4593 17 Teaching Teaching NNP cord-023095-4dannjjm 4593 18 Hospital Hospital NNP cord-023095-4dannjjm 4593 19 between between IN cord-023095-4dannjjm 4593 20 2006 2006 CD cord-023095-4dannjjm 4593 21 and and CC cord-023095-4dannjjm 4593 22 2010 2010 CD cord-023095-4dannjjm 4593 23 were be VBD cord-023095-4dannjjm 4593 24 reviewed review VBN cord-023095-4dannjjm 4593 25 . . . cord-023095-4dannjjm 4594 1 Signalment Signalment NNP cord-023095-4dannjjm 4594 2 , , , cord-023095-4dannjjm 4594 3 presenting present VBG cord-023095-4dannjjm 4594 4 clinical clinical JJ cord-023095-4dannjjm 4594 5 signs sign NNS cord-023095-4dannjjm 4594 6 , , , cord-023095-4dannjjm 4594 7 physical physical JJ cord-023095-4dannjjm 4594 8 and and CC cord-023095-4dannjjm 4594 9 neurologic neurologic JJ cord-023095-4dannjjm 4594 10 examination examination NN cord-023095-4dannjjm 4594 11 , , , cord-023095-4dannjjm 4594 12 clinicopathologic clinicopathologic NNP cord-023095-4dannjjm 4594 13 data datum NNS cord-023095-4dannjjm 4594 14 , , , cord-023095-4dannjjm 4594 15 surgery surgery NN cord-023095-4dannjjm 4594 16 reports report NNS cord-023095-4dannjjm 4594 17 and and CC cord-023095-4dannjjm 4594 18 available available JJ cord-023095-4dannjjm 4594 19 images image NNS cord-023095-4dannjjm 4594 20 were be VBD cord-023095-4dannjjm 4594 21 reviewed review VBN cord-023095-4dannjjm 4594 22 . . . cord-023095-4dannjjm 4595 1 All all DT cord-023095-4dannjjm 4595 2 meningiomas meningioma NNS cord-023095-4dannjjm 4595 3 were be VBD cord-023095-4dannjjm 4595 4 histologically histologically RB cord-023095-4dannjjm 4595 5 classified classify VBN cord-023095-4dannjjm 4595 6 and and CC cord-023095-4dannjjm 4595 7 graded grade VBD cord-023095-4dannjjm 4595 8 following follow VBG cord-023095-4dannjjm 4595 9 the the DT cord-023095-4dannjjm 4595 10 international international JJ cord-023095-4dannjjm 4595 11 WHO WHO NNP cord-023095-4dannjjm 4595 12 human human JJ cord-023095-4dannjjm 4595 13 classification classification NN cord-023095-4dannjjm 4595 14 for for IN cord-023095-4dannjjm 4595 15 CNS CNS NNP cord-023095-4dannjjm 4595 16 tumors tumor NNS cord-023095-4dannjjm 4595 17 . . . cord-023095-4dannjjm 4596 1 Seven seven CD cord-023095-4dannjjm 4596 2 dogs dog NNS cord-023095-4dannjjm 4596 3 were be VBD cord-023095-4dannjjm 4596 4 included include VBN cord-023095-4dannjjm 4596 5 , , , cord-023095-4dannjjm 4596 6 4 4 CD cord-023095-4dannjjm 4596 7 males male NNS cord-023095-4dannjjm 4596 8 and and CC cord-023095-4dannjjm 4596 9 3 3 CD cord-023095-4dannjjm 4596 10 females female NNS cord-023095-4dannjjm 4596 11 . . . cord-023095-4dannjjm 4597 1 Median median JJ cord-023095-4dannjjm 4597 2 age age NN cord-023095-4dannjjm 4597 3 at at IN cord-023095-4dannjjm 4597 4 presentation presentation NN cord-023095-4dannjjm 4597 5 was be VBD cord-023095-4dannjjm 4597 6 8.7 8.7 CD cord-023095-4dannjjm 4597 7 years year NNS cord-023095-4dannjjm 4597 8 ( ( -LRB- cord-023095-4dannjjm 4597 9 range range NN cord-023095-4dannjjm 4597 10 , , , cord-023095-4dannjjm 4597 11 3.5 3.5 CD cord-023095-4dannjjm 4597 12 - - HYPH cord-023095-4dannjjm 4597 13 11.4 11.4 CD cord-023095-4dannjjm 4597 14 years year NNS cord-023095-4dannjjm 4597 15 ) ) -RRB- cord-023095-4dannjjm 4597 16 , , , cord-023095-4dannjjm 4597 17 and and CC cord-023095-4dannjjm 4597 18 median median JJ cord-023095-4dannjjm 4597 19 weight weight NN cord-023095-4dannjjm 4597 20 was be VBD cord-023095-4dannjjm 4597 21 35 35 CD cord-023095-4dannjjm 4597 22 kg kg NN cord-023095-4dannjjm 4597 23 ( ( -LRB- cord-023095-4dannjjm 4597 24 range range NN cord-023095-4dannjjm 4597 25 , , , cord-023095-4dannjjm 4597 26 8 8 CD cord-023095-4dannjjm 4597 27 - - SYM cord-023095-4dannjjm 4597 28 45 45 CD cord-023095-4dannjjm 4597 29 kg kg NNS cord-023095-4dannjjm 4597 30 ) ) -RRB- cord-023095-4dannjjm 4597 31 . . . cord-023095-4dannjjm 4598 1 Median median JJ cord-023095-4dannjjm 4598 2 time time NN cord-023095-4dannjjm 4598 3 between between IN cord-023095-4dannjjm 4598 4 onset onset NN cord-023095-4dannjjm 4598 5 of of IN cord-023095-4dannjjm 4598 6 clinical clinical JJ cord-023095-4dannjjm 4598 7 signs sign NNS cord-023095-4dannjjm 4598 8 and and CC cord-023095-4dannjjm 4598 9 diagnosis diagnosis NN cord-023095-4dannjjm 4598 10 was be VBD cord-023095-4dannjjm 4598 11 108 108 CD cord-023095-4dannjjm 4598 12 days day NNS cord-023095-4dannjjm 4598 13 ( ( -LRB- cord-023095-4dannjjm 4598 14 range range NN cord-023095-4dannjjm 4598 15 , , , cord-023095-4dannjjm 4598 16 45 45 CD cord-023095-4dannjjm 4598 17 days day NNS cord-023095-4dannjjm 4598 18 -1 -1 NNP cord-023095-4dannjjm 4598 19 year year NN cord-023095-4dannjjm 4598 20 ) ) -RRB- cord-023095-4dannjjm 4598 21 . . . cord-023095-4dannjjm 4599 1 Cerebrospinal cerebrospinal NN cord-023095-4dannjjm 4599 2 fluid fluid NN cord-023095-4dannjjm 4599 3 ( ( -LRB- cord-023095-4dannjjm 4599 4 CSF CSF NNP cord-023095-4dannjjm 4599 5 ) ) -RRB- cord-023095-4dannjjm 4599 6 analysis analysis NN cord-023095-4dannjjm 4599 7 was be VBD cord-023095-4dannjjm 4599 8 performed perform VBN cord-023095-4dannjjm 4599 9 in in IN cord-023095-4dannjjm 4599 10 4 4 CD cord-023095-4dannjjm 4599 11 dogs dog NNS cord-023095-4dannjjm 4599 12 , , , cord-023095-4dannjjm 4599 13 showing show VBG cord-023095-4dannjjm 4599 14 increased increase VBN cord-023095-4dannjjm 4599 15 protein protein NN cord-023095-4dannjjm 4599 16 concentration concentration NN cord-023095-4dannjjm 4599 17 in in IN cord-023095-4dannjjm 4599 18 2 2 CD cord-023095-4dannjjm 4599 19 cases case NNS cord-023095-4dannjjm 4599 20 , , , cord-023095-4dannjjm 4599 21 and and CC cord-023095-4dannjjm 4599 22 being be VBG cord-023095-4dannjjm 4599 23 normal normal JJ cord-023095-4dannjjm 4599 24 in in IN cord-023095-4dannjjm 4599 25 the the DT cord-023095-4dannjjm 4599 26 other other JJ cord-023095-4dannjjm 4599 27 2 2 CD cord-023095-4dannjjm 4599 28 . . . cord-023095-4dannjjm 4600 1 Spinal spinal JJ cord-023095-4dannjjm 4600 2 radiographs radiograph NNS cord-023095-4dannjjm 4600 3 revealed reveal VBD cord-023095-4dannjjm 4600 4 vertebral vertebral JJ cord-023095-4dannjjm 4600 5 canal canal NN cord-023095-4dannjjm 4600 6 widening widen VBG cord-023095-4dannjjm 4600 7 in in IN cord-023095-4dannjjm 4600 8 one one CD cord-023095-4dannjjm 4600 9 case case NN cord-023095-4dannjjm 4600 10 . . . cord-023095-4dannjjm 4601 1 Myelography Myelography NNP cord-023095-4dannjjm 4601 2 ( ( -LRB- cord-023095-4dannjjm 4601 3 4/7 4/7 CD cord-023095-4dannjjm 4601 4 ) ) -RRB- cord-023095-4dannjjm 4601 5 showed show VBD cord-023095-4dannjjm 4601 6 intradural intradural JJ cord-023095-4dannjjm 4601 7 / / SYM cord-023095-4dannjjm 4601 8 extramedullary extramedullary JJ cord-023095-4dannjjm 4601 9 lesions lesion NNS cord-023095-4dannjjm 4601 10 in in IN cord-023095-4dannjjm 4601 11 three three CD cord-023095-4dannjjm 4601 12 cases case NNS cord-023095-4dannjjm 4601 13 , , , cord-023095-4dannjjm 4601 14 one one CD cord-023095-4dannjjm 4601 15 of of IN cord-023095-4dannjjm 4601 16 them -PRON- PRP cord-023095-4dannjjm 4601 17 consistent consistent JJ cord-023095-4dannjjm 4601 18 with with IN cord-023095-4dannjjm 4601 19 a a DT cord-023095-4dannjjm 4601 20 CSF CSF NNP cord-023095-4dannjjm 4601 21 - - HYPH cord-023095-4dannjjm 4601 22 filled fill VBN cord-023095-4dannjjm 4601 23 subarachnoid subarachnoid NN cord-023095-4dannjjm 4601 24 cavity cavity NN cord-023095-4dannjjm 4601 25 , , , cord-023095-4dannjjm 4601 26 and and CC cord-023095-4dannjjm 4601 27 an an DT cord-023095-4dannjjm 4601 28 extradural extradural JJ cord-023095-4dannjjm 4601 29 lesion lesion NN cord-023095-4dannjjm 4601 30 in in IN cord-023095-4dannjjm 4601 31 one one CD cord-023095-4dannjjm 4601 32 case case NN cord-023095-4dannjjm 4601 33 . . . cord-023095-4dannjjm 4602 1 Magnetic magnetic JJ cord-023095-4dannjjm 4602 2 resonance resonance NN cord-023095-4dannjjm 4602 3 imaging imaging NN cord-023095-4dannjjm 4602 4 ( ( -LRB- cord-023095-4dannjjm 4602 5 MRI MRI NNP cord-023095-4dannjjm 4602 6 ) ) -RRB- cord-023095-4dannjjm 4602 7 was be VBD cord-023095-4dannjjm 4602 8 performed perform VBN cord-023095-4dannjjm 4602 9 in in IN cord-023095-4dannjjm 4602 10 all all DT cord-023095-4dannjjm 4602 11 cases case NNS cord-023095-4dannjjm 4602 12 and and CC cord-023095-4dannjjm 4602 13 revealed reveal VBD cord-023095-4dannjjm 4602 14 mild mild JJ cord-023095-4dannjjm 4602 15 to to IN cord-023095-4dannjjm 4602 16 marked mark VBN cord-023095-4dannjjm 4602 17 hyperintensity hyperintensity NN cord-023095-4dannjjm 4602 18 on on IN cord-023095-4dannjjm 4602 19 T2W t2w CD cord-023095-4dannjjm 4602 20 and and CC cord-023095-4dannjjm 4602 21 precontrast precontrast NN cord-023095-4dannjjm 4602 22 T1W t1w CD cord-023095-4dannjjm 4602 23 images image NNS cord-023095-4dannjjm 4602 24 and and CC cord-023095-4dannjjm 4602 25 homogeneous homogeneous JJ cord-023095-4dannjjm 4602 26 contrast contrast NN cord-023095-4dannjjm 4602 27 enhancing enhance VBG cord-023095-4dannjjm 4602 28 ( ( -LRB- cord-023095-4dannjjm 4602 29 CE CE NNP cord-023095-4dannjjm 4602 30 ) ) -RRB- cord-023095-4dannjjm 4602 31 intradural intradural JJ cord-023095-4dannjjm 4602 32 / / SYM cord-023095-4dannjjm 4602 33 extramedullary extramedullary JJ cord-023095-4dannjjm 4602 34 masses masse NNS cord-023095-4dannjjm 4602 35 ( ( -LRB- cord-023095-4dannjjm 4602 36 4 4 CD cord-023095-4dannjjm 4602 37 cervical cervical JJ cord-023095-4dannjjm 4602 38 and and CC cord-023095-4dannjjm 4602 39 2 2 CD cord-023095-4dannjjm 4602 40 thoracic thoracic JJ cord-023095-4dannjjm 4602 41 ) ) -RRB- cord-023095-4dannjjm 4602 42 in in IN cord-023095-4dannjjm 4602 43 six six CD cord-023095-4dannjjm 4602 44 cases case NNS cord-023095-4dannjjm 4602 45 , , , cord-023095-4dannjjm 4602 46 with with IN cord-023095-4dannjjm 4602 47 one one CD cord-023095-4dannjjm 4602 48 of of IN cord-023095-4dannjjm 4602 49 these these DT cord-023095-4dannjjm 4602 50 showing show VBG cord-023095-4dannjjm 4602 51 an an DT cord-023095-4dannjjm 4602 52 additional additional JJ cord-023095-4dannjjm 4602 53 intramedullary intramedullary JJ cord-023095-4dannjjm 4602 54 CE ce NN cord-023095-4dannjjm 4602 55 pattern pattern NN cord-023095-4dannjjm 4602 56 . . . cord-023095-4dannjjm 4603 1 A a DT cord-023095-4dannjjm 4603 2 dural dural JJ cord-023095-4dannjjm 4603 3 tail tail NN cord-023095-4dannjjm 4603 4 was be VBD cord-023095-4dannjjm 4603 5 identified identify VBN cord-023095-4dannjjm 4603 6 in in IN cord-023095-4dannjjm 4603 7 two two CD cord-023095-4dannjjm 4603 8 dogs dog NNS cord-023095-4dannjjm 4603 9 . . . cord-023095-4dannjjm 4604 1 One one CD cord-023095-4dannjjm 4604 2 dog dog NN cord-023095-4dannjjm 4604 3 had have VBD cord-023095-4dannjjm 4604 4 a a DT cord-023095-4dannjjm 4604 5 fluid fluid NN cord-023095-4dannjjm 4604 6 - - HYPH cord-023095-4dannjjm 4604 7 filled fill VBN cord-023095-4dannjjm 4604 8 subarachnoid subarachnoid NN cord-023095-4dannjjm 4604 9 enlargement enlargement NN cord-023095-4dannjjm 4604 10 located locate VBN cord-023095-4dannjjm 4604 11 dorsally dorsally RB cord-023095-4dannjjm 4604 12 to to IN cord-023095-4dannjjm 4604 13 the the DT cord-023095-4dannjjm 4604 14 spinal spinal JJ cord-023095-4dannjjm 4604 15 cord cord NN cord-023095-4dannjjm 4604 16 . . . cord-023095-4dannjjm 4605 1 This this DT cord-023095-4dannjjm 4605 2 lesion lesion NN cord-023095-4dannjjm 4605 3 was be VBD cord-023095-4dannjjm 4605 4 hyperintense hyperintense NN cord-023095-4dannjjm 4605 5 on on IN cord-023095-4dannjjm 4605 6 T2W T2W NNP cord-023095-4dannjjm 4605 7 , , , cord-023095-4dannjjm 4605 8 hypointense hypointense NN cord-023095-4dannjjm 4605 9 on on IN cord-023095-4dannjjm 4605 10 T1W T1W NNP cord-023095-4dannjjm 4605 11 and and CC cord-023095-4dannjjm 4605 12 FLAIR flair NN cord-023095-4dannjjm 4605 13 images image NNS cord-023095-4dannjjm 4605 14 , , , cord-023095-4dannjjm 4605 15 and and CC cord-023095-4dannjjm 4605 16 did do VBD cord-023095-4dannjjm 4605 17 not not RB cord-023095-4dannjjm 4605 18 enhance enhance VB cord-023095-4dannjjm 4605 19 . . . cord-023095-4dannjjm 4606 1 It -PRON- PRP cord-023095-4dannjjm 4606 2 was be VBD cord-023095-4dannjjm 4606 3 diagnosed diagnose VBN cord-023095-4dannjjm 4606 4 as as IN cord-023095-4dannjjm 4606 5 a a DT cord-023095-4dannjjm 4606 6 spinal spinal JJ cord-023095-4dannjjm 4606 7 subarachnoid subarachnoid NN cord-023095-4dannjjm 4606 8 cyst cyst NN cord-023095-4dannjjm 4606 9 , , , cord-023095-4dannjjm 4606 10 but but CC cord-023095-4dannjjm 4606 11 the the DT cord-023095-4dannjjm 4606 12 histopathological histopathological JJ cord-023095-4dannjjm 4606 13 study study NN cord-023095-4dannjjm 4606 14 of of IN cord-023095-4dannjjm 4606 15 the the DT cord-023095-4dannjjm 4606 16 surgically surgically RB cord-023095-4dannjjm 4606 17 resected resect VBN cord-023095-4dannjjm 4606 18 mass mass NN cord-023095-4dannjjm 4606 19 revealed reveal VBD cord-023095-4dannjjm 4606 20 a a DT cord-023095-4dannjjm 4606 21 grade grade NN cord-023095-4dannjjm 4606 22 I -PRON- PRP cord-023095-4dannjjm 4606 23 cystic cystic JJ cord-023095-4dannjjm 4606 24 meningioma meningioma NN cord-023095-4dannjjm 4606 25 . . . cord-023095-4dannjjm 4607 1 Five five CD cord-023095-4dannjjm 4607 2 other other JJ cord-023095-4dannjjm 4607 3 cases case NNS cord-023095-4dannjjm 4607 4 underwent undergo VBD cord-023095-4dannjjm 4607 5 cytoreductive cytoreductive JJ cord-023095-4dannjjm 4607 6 surgery surgery NN cord-023095-4dannjjm 4607 7 , , , cord-023095-4dannjjm 4607 8 two two CD cord-023095-4dannjjm 4607 9 transitional transitional JJ cord-023095-4dannjjm 4607 10 meningiomas meningiomas NN cord-023095-4dannjjm 4607 11 ( ( -LRB- cord-023095-4dannjjm 4607 12 grade grade NN cord-023095-4dannjjm 4607 13 I I NNP cord-023095-4dannjjm 4607 14 ) ) -RRB- cord-023095-4dannjjm 4607 15 that that WDT cord-023095-4dannjjm 4607 16 survived survive VBD cord-023095-4dannjjm 4607 17 3 3 CD cord-023095-4dannjjm 4607 18 ( ( -LRB- cord-023095-4dannjjm 4607 19 alive alive JJ cord-023095-4dannjjm 4607 20 at at IN cord-023095-4dannjjm 4607 21 the the DT cord-023095-4dannjjm 4607 22 time time NN cord-023095-4dannjjm 4607 23 of of IN cord-023095-4dannjjm 4607 24 writing writing NN cord-023095-4dannjjm 4607 25 ) ) -RRB- cord-023095-4dannjjm 4607 26 and and CC cord-023095-4dannjjm 4607 27 7 7 CD cord-023095-4dannjjm 4607 28 months month NNS cord-023095-4dannjjm 4607 29 ; ; : cord-023095-4dannjjm 4607 30 and and CC cord-023095-4dannjjm 4607 31 three three CD cord-023095-4dannjjm 4607 32 anaplastic anaplastic JJ cord-023095-4dannjjm 4607 33 meningiomas meningiomas NN cord-023095-4dannjjm 4607 34 ( ( -LRB- cord-023095-4dannjjm 4607 35 grade grade NN cord-023095-4dannjjm 4607 36 III iii CD cord-023095-4dannjjm 4607 37 ) ) -RRB- cord-023095-4dannjjm 4607 38 that that WDT cord-023095-4dannjjm 4607 39 survived survive VBD cord-023095-4dannjjm 4607 40 10 10 CD cord-023095-4dannjjm 4607 41 - - SYM cord-023095-4dannjjm 4607 42 16.6 16.6 CD cord-023095-4dannjjm 4607 43 months month NNS cord-023095-4dannjjm 4607 44 before before IN cord-023095-4dannjjm 4607 45 neurological neurological JJ cord-023095-4dannjjm 4607 46 deterioration deterioration NN cord-023095-4dannjjm 4607 47 and and CC cord-023095-4dannjjm 4607 48 euthanasia euthanasia NN cord-023095-4dannjjm 4607 49 . . . cord-023095-4dannjjm 4608 1 Another another DT cord-023095-4dannjjm 4608 2 anaplastic anaplastic JJ cord-023095-4dannjjm 4608 3 meningioma meningioma NN cord-023095-4dannjjm 4608 4 was be VBD cord-023095-4dannjjm 4608 5 euthanized euthanize VBN cord-023095-4dannjjm 4608 6 right right RB cord-023095-4dannjjm 4608 7 after after IN cord-023095-4dannjjm 4608 8 diagnosis diagnosis NN cord-023095-4dannjjm 4608 9 . . . cord-023095-4dannjjm 4609 1 There there EX cord-023095-4dannjjm 4609 2 are be VBP cord-023095-4dannjjm 4609 3 few few JJ cord-023095-4dannjjm 4609 4 reports report NNS cord-023095-4dannjjm 4609 5 grading grade VBG cord-023095-4dannjjm 4609 6 canine canine JJ cord-023095-4dannjjm 4609 7 spinal spinal JJ cord-023095-4dannjjm 4609 8 meningiomas meningiomas NN cord-023095-4dannjjm 4609 9 , , , cord-023095-4dannjjm 4609 10 with with IN cord-023095-4dannjjm 4609 11 most most JJS cord-023095-4dannjjm 4609 12 being be VBG cord-023095-4dannjjm 4609 13 grade grade NN cord-023095-4dannjjm 4609 14 I -PRON- PRP cord-023095-4dannjjm 4609 15 or or CC cord-023095-4dannjjm 4609 16 II II NNP cord-023095-4dannjjm 4609 17 . . . cord-023095-4dannjjm 4610 1 Of of IN cord-023095-4dannjjm 4610 2 the the DT cord-023095-4dannjjm 4610 3 few few JJ cord-023095-4dannjjm 4610 4 grade grade NN cord-023095-4dannjjm 4610 5 III iii CD cord-023095-4dannjjm 4610 6 tumors tumor NNS cord-023095-4dannjjm 4610 7 reported report VBN cord-023095-4dannjjm 4610 8 , , , cord-023095-4dannjjm 4610 9 only only RB cord-023095-4dannjjm 4610 10 one one CD cord-023095-4dannjjm 4610 11 had have VBD cord-023095-4dannjjm 4610 12 been be VBN cord-023095-4dannjjm 4610 13 treated treat VBN cord-023095-4dannjjm 4610 14 surgically surgically RB cord-023095-4dannjjm 4610 15 and and CC cord-023095-4dannjjm 4610 16 was be VBD cord-023095-4dannjjm 4610 17 euthanized euthanize VBN cord-023095-4dannjjm 4610 18 90 90 CD cord-023095-4dannjjm 4610 19 days day NNS cord-023095-4dannjjm 4610 20 later later RB cord-023095-4dannjjm 4610 21 because because IN cord-023095-4dannjjm 4610 22 of of IN cord-023095-4dannjjm 4610 23 neurological neurological JJ cord-023095-4dannjjm 4610 24 deterioration deterioration NN cord-023095-4dannjjm 4610 25 . . . cord-023095-4dannjjm 4611 1 We -PRON- PRP cord-023095-4dannjjm 4611 2 report report VBP cord-023095-4dannjjm 4611 3 four four CD cord-023095-4dannjjm 4611 4 grade grade NN cord-023095-4dannjjm 4611 5 III iii CD cord-023095-4dannjjm 4611 6 ( ( -LRB- cord-023095-4dannjjm 4611 7 anaplastic anaplastic JJ cord-023095-4dannjjm 4611 8 ) ) -RRB- cord-023095-4dannjjm 4611 9 meningiomas meningiomas NN cord-023095-4dannjjm 4611 10 , , , cord-023095-4dannjjm 4611 11 three three CD cord-023095-4dannjjm 4611 12 of of IN cord-023095-4dannjjm 4611 13 which which WDT cord-023095-4dannjjm 4611 14 surgically surgically RB cord-023095-4dannjjm 4611 15 treated treat VBN cord-023095-4dannjjm 4611 16 and and CC cord-023095-4dannjjm 4611 17 with with IN cord-023095-4dannjjm 4611 18 longer long JJR cord-023095-4dannjjm 4611 19 survival survival NN cord-023095-4dannjjm 4611 20 times time NNS cord-023095-4dannjjm 4611 21 . . . cord-023095-4dannjjm 4612 1 Finally finally RB cord-023095-4dannjjm 4612 2 , , , cord-023095-4dannjjm 4612 3 cystic cystic JJ cord-023095-4dannjjm 4612 4 meningioma meningioma NN cord-023095-4dannjjm 4612 5 should should MD cord-023095-4dannjjm 4612 6 be be VB cord-023095-4dannjjm 4612 7 considered consider VBN cord-023095-4dannjjm 4612 8 in in IN cord-023095-4dannjjm 4612 9 the the DT cord-023095-4dannjjm 4612 10 differential differential JJ cord-023095-4dannjjm 4612 11 diagnosis diagnosis NN cord-023095-4dannjjm 4612 12 of of IN cord-023095-4dannjjm 4612 13 cases case NNS cord-023095-4dannjjm 4612 14 with with IN cord-023095-4dannjjm 4612 15 imaging imaging NN cord-023095-4dannjjm 4612 16 features feature NNS cord-023095-4dannjjm 4612 17 consistent consistent JJ cord-023095-4dannjjm 4612 18 with with IN cord-023095-4dannjjm 4612 19 arachnoid arachnoid JJ cord-023095-4dannjjm 4612 20 cyst cyst NN cord-023095-4dannjjm 4612 21 because because IN cord-023095-4dannjjm 4612 22 of of IN cord-023095-4dannjjm 4612 23 their -PRON- PRP$ cord-023095-4dannjjm 4612 24 similar similar JJ cord-023095-4dannjjm 4612 25 appearance appearance NN cord-023095-4dannjjm 4612 26 , , , cord-023095-4dannjjm 4612 27 making make VBG cord-023095-4dannjjm 4612 28 histopathological histopathological JJ cord-023095-4dannjjm 4612 29 analysis analysis NN cord-023095-4dannjjm 4612 30 essential essential JJ cord-023095-4dannjjm 4612 31 for for IN cord-023095-4dannjjm 4612 32 a a DT cord-023095-4dannjjm 4612 33 definitive definitive JJ cord-023095-4dannjjm 4612 34 diagnosis diagnosis NN cord-023095-4dannjjm 4612 35 . . . cord-023095-4dannjjm 4613 1 Head Head NNP cord-023095-4dannjjm 4613 2 trauma trauma NN cord-023095-4dannjjm 4613 3 is be VBZ cord-023095-4dannjjm 4613 4 a a DT cord-023095-4dannjjm 4613 5 common common JJ cord-023095-4dannjjm 4613 6 veterinary veterinary JJ cord-023095-4dannjjm 4613 7 emergency emergency NN cord-023095-4dannjjm 4613 8 , , , cord-023095-4dannjjm 4613 9 but but CC cord-023095-4dannjjm 4613 10 few few JJ cord-023095-4dannjjm 4613 11 prognostic prognostic JJ cord-023095-4dannjjm 4613 12 indicators indicator NNS cord-023095-4dannjjm 4613 13 have have VBP cord-023095-4dannjjm 4613 14 been be VBN cord-023095-4dannjjm 4613 15 studied study VBN cord-023095-4dannjjm 4613 16 in in IN cord-023095-4dannjjm 4613 17 dogs dog NNS cord-023095-4dannjjm 4613 18 , , , cord-023095-4dannjjm 4613 19 making make VBG cord-023095-4dannjjm 4613 20 it -PRON- PRP cord-023095-4dannjjm 4613 21 challenging challenging JJ cord-023095-4dannjjm 4613 22 for for IN cord-023095-4dannjjm 4613 23 clinicians clinician NNS cord-023095-4dannjjm 4613 24 to to TO cord-023095-4dannjjm 4613 25 counsel counsel VB cord-023095-4dannjjm 4613 26 clients client NNS cord-023095-4dannjjm 4613 27 about about IN cord-023095-4dannjjm 4613 28 the the DT cord-023095-4dannjjm 4613 29 odds odd NNS cord-023095-4dannjjm 4613 30 of of IN cord-023095-4dannjjm 4613 31 recovery recovery NN cord-023095-4dannjjm 4613 32 . . . cord-023095-4dannjjm 4614 1 A a DT cord-023095-4dannjjm 4614 2 recent recent JJ cord-023095-4dannjjm 4614 3 meta meta JJ cord-023095-4dannjjm 4614 4 - - HYPH cord-023095-4dannjjm 4614 5 analysis analysis NN cord-023095-4dannjjm 4614 6 showed show VBD cord-023095-4dannjjm 4614 7 that that IN cord-023095-4dannjjm 4614 8 higher high JJR cord-023095-4dannjjm 4614 9 plasma plasma NN cord-023095-4dannjjm 4614 10 glucose glucose NN cord-023095-4dannjjm 4614 11 , , , cord-023095-4dannjjm 4614 12 lower low JJR cord-023095-4dannjjm 4614 13 plasma plasma NN cord-023095-4dannjjm 4614 14 pH ph NN cord-023095-4dannjjm 4614 15 and and CC cord-023095-4dannjjm 4614 16 lower low JJR cord-023095-4dannjjm 4614 17 hemoglobin hemoglobin NN cord-023095-4dannjjm 4614 18 at at IN cord-023095-4dannjjm 4614 19 admission admission NN cord-023095-4dannjjm 4614 20 were be VBD cord-023095-4dannjjm 4614 21 associated associate VBN cord-023095-4dannjjm 4614 22 with with IN cord-023095-4dannjjm 4614 23 increased increase VBN cord-023095-4dannjjm 4614 24 risk risk NN cord-023095-4dannjjm 4614 25 of of IN cord-023095-4dannjjm 4614 26 death death NN cord-023095-4dannjjm 4614 27 in in IN cord-023095-4dannjjm 4614 28 human human JJ cord-023095-4dannjjm 4614 29 head head NN cord-023095-4dannjjm 4614 30 trauma trauma NN cord-023095-4dannjjm 4614 31 . . . cord-023095-4dannjjm 4615 1 The the DT cord-023095-4dannjjm 4615 2 goal goal NN cord-023095-4dannjjm 4615 3 of of IN cord-023095-4dannjjm 4615 4 this this DT cord-023095-4dannjjm 4615 5 retrospective retrospective JJ cord-023095-4dannjjm 4615 6 study study NN cord-023095-4dannjjm 4615 7 was be VBD cord-023095-4dannjjm 4615 8 to to TO cord-023095-4dannjjm 4615 9 investigate investigate VB cord-023095-4dannjjm 4615 10 the the DT cord-023095-4dannjjm 4615 11 association association NN cord-023095-4dannjjm 4615 12 between between IN cord-023095-4dannjjm 4615 13 admission admission NN cord-023095-4dannjjm 4615 14 point point NN cord-023095-4dannjjm 4615 15 of of IN cord-023095-4dannjjm 4615 16 care care NN cord-023095-4dannjjm 4615 17 blood blood NN cord-023095-4dannjjm 4615 18 gas gas NN cord-023095-4dannjjm 4615 19 parameters parameter NNS cord-023095-4dannjjm 4615 20 and and CC cord-023095-4dannjjm 4615 21 survival survival NN cord-023095-4dannjjm 4615 22 to to TO cord-023095-4dannjjm 4615 23 discharge discharge VB cord-023095-4dannjjm 4615 24 in in IN cord-023095-4dannjjm 4615 25 dogs dog NNS cord-023095-4dannjjm 4615 26 with with IN cord-023095-4dannjjm 4615 27 head head NN cord-023095-4dannjjm 4615 28 trauma trauma NN cord-023095-4dannjjm 4615 29 . . . cord-023095-4dannjjm 4616 1 Fifty fifty CD cord-023095-4dannjjm 4616 2 one one CD cord-023095-4dannjjm 4616 3 dogs dog NNS cord-023095-4dannjjm 4616 4 presenting present VBG cord-023095-4dannjjm 4616 5 to to IN cord-023095-4dannjjm 4616 6 the the DT cord-023095-4dannjjm 4616 7 Cornell Cornell NNP cord-023095-4dannjjm 4616 8 University University NNP cord-023095-4dannjjm 4616 9 Hospital Hospital NNP cord-023095-4dannjjm 4616 10 for for IN cord-023095-4dannjjm 4616 11 Animals animal NNS cord-023095-4dannjjm 4616 12 with with IN cord-023095-4dannjjm 4616 13 head head NN cord-023095-4dannjjm 4616 14 trauma trauma NN cord-023095-4dannjjm 4616 15 from from IN cord-023095-4dannjjm 4616 16 2007 2007 CD cord-023095-4dannjjm 4616 17 to to IN cord-023095-4dannjjm 4616 18 2010 2010 CD cord-023095-4dannjjm 4616 19 that that WDT cord-023095-4dannjjm 4616 20 had have VBD cord-023095-4dannjjm 4616 21 a a DT cord-023095-4dannjjm 4616 22 blood blood NN cord-023095-4dannjjm 4616 23 gas gas NN cord-023095-4dannjjm 4616 24 analysis analysis NN cord-023095-4dannjjm 4616 25 done do VBN cord-023095-4dannjjm 4616 26 within within IN cord-023095-4dannjjm 4616 27 1 1 CD cord-023095-4dannjjm 4616 28 hour hour NN cord-023095-4dannjjm 4616 29 of of IN cord-023095-4dannjjm 4616 30 presentation presentation NN cord-023095-4dannjjm 4616 31 were be VBD cord-023095-4dannjjm 4616 32 eligible eligible JJ cord-023095-4dannjjm 4616 33 for for IN cord-023095-4dannjjm 4616 34 inclusion inclusion NN cord-023095-4dannjjm 4616 35 . . . cord-023095-4dannjjm 4617 1 Parameters parameter NNS cord-023095-4dannjjm 4617 2 assessed assess VBD cord-023095-4dannjjm 4617 3 included include VBD cord-023095-4dannjjm 4617 4 glucose glucose NN cord-023095-4dannjjm 4617 5 , , , cord-023095-4dannjjm 4617 6 base base NN cord-023095-4dannjjm 4617 7 excess excess NN cord-023095-4dannjjm 4617 8 ( ( -LRB- cord-023095-4dannjjm 4617 9 BE be VB cord-023095-4dannjjm 4617 10 ) ) -RRB- cord-023095-4dannjjm 4617 11 , , , cord-023095-4dannjjm 4617 12 anion anion NN cord-023095-4dannjjm 4617 13 gap gap NN cord-023095-4dannjjm 4617 14 ( ( -LRB- cord-023095-4dannjjm 4617 15 AG AG NNP cord-023095-4dannjjm 4617 16 ) ) -RRB- cord-023095-4dannjjm 4617 17 , , , cord-023095-4dannjjm 4617 18 pH ph NN cord-023095-4dannjjm 4617 19 , , , cord-023095-4dannjjm 4617 20 hemoglobin hemoglobin NN cord-023095-4dannjjm 4617 21 , , , cord-023095-4dannjjm 4617 22 and and CC cord-023095-4dannjjm 4617 23 sodium sodium NN cord-023095-4dannjjm 4617 24 . . . cord-023095-4dannjjm 4618 1 Biochemical biochemical JJ cord-023095-4dannjjm 4618 2 data datum NNS cord-023095-4dannjjm 4618 3 were be VBD cord-023095-4dannjjm 4618 4 found find VBN cord-023095-4dannjjm 4618 5 to to TO cord-023095-4dannjjm 4618 6 be be VB cord-023095-4dannjjm 4618 7 normally normally RB cord-023095-4dannjjm 4618 8 distributed distribute VBN cord-023095-4dannjjm 4618 9 using use VBG cord-023095-4dannjjm 4618 10 the the DT cord-023095-4dannjjm 4618 11 Kolmogorov Kolmogorov NNP cord-023095-4dannjjm 4618 12 - - HYPH cord-023095-4dannjjm 4618 13 Smirnov Smirnov NNP cord-023095-4dannjjm 4618 14 test test NN cord-023095-4dannjjm 4618 15 . . . cord-023095-4dannjjm 4619 1 T t NN cord-023095-4dannjjm 4619 2 - - HYPH cord-023095-4dannjjm 4619 3 tests test NNS cord-023095-4dannjjm 4619 4 or or CC cord-023095-4dannjjm 4619 5 Welch Welch NNP cord-023095-4dannjjm 4619 6 tests test NNS cord-023095-4dannjjm 4619 7 were be VBD cord-023095-4dannjjm 4619 8 used use VBN cord-023095-4dannjjm 4619 9 to to TO cord-023095-4dannjjm 4619 10 compare compare VB cord-023095-4dannjjm 4619 11 parameters parameter NNS cord-023095-4dannjjm 4619 12 between between IN cord-023095-4dannjjm 4619 13 survivors survivor NNS cord-023095-4dannjjm 4619 14 ( ( -LRB- cord-023095-4dannjjm 4619 15 S S NNP cord-023095-4dannjjm 4619 16 , , , cord-023095-4dannjjm 4619 17 n n NN cord-023095-4dannjjm 4619 18 5 5 CD cord-023095-4dannjjm 4619 19 42 42 CD cord-023095-4dannjjm 4619 20 ) ) -RRB- cord-023095-4dannjjm 4619 21 and and CC cord-023095-4dannjjm 4619 22 non non NNS cord-023095-4dannjjm 4619 23 - - NNS cord-023095-4dannjjm 4619 24 survivors survivor NNS cord-023095-4dannjjm 4619 25 ( ( -LRB- cord-023095-4dannjjm 4619 26 NS NS NNP cord-023095-4dannjjm 4619 27 , , , cord-023095-4dannjjm 4619 28 n n NN cord-023095-4dannjjm 4619 29 5 5 CD cord-023095-4dannjjm 4619 30 9 9 CD cord-023095-4dannjjm 4619 31 ) ) -RRB- cord-023095-4dannjjm 4619 32 . . . cord-023095-4dannjjm 4620 1 Of of IN cord-023095-4dannjjm 4620 2 glucose glucose NN cord-023095-4dannjjm 4620 3 , , , cord-023095-4dannjjm 4620 4 BE be VB cord-023095-4dannjjm 4620 5 , , , cord-023095-4dannjjm 4620 6 AG AG NNP cord-023095-4dannjjm 4620 7 , , , cord-023095-4dannjjm 4620 8 pH ph NN cord-023095-4dannjjm 4620 9 , , , cord-023095-4dannjjm 4620 10 hemoglobin hemoglobin NN cord-023095-4dannjjm 4620 11 , , , cord-023095-4dannjjm 4620 12 and and CC cord-023095-4dannjjm 4620 13 sodium sodium NN cord-023095-4dannjjm 4620 14 , , , cord-023095-4dannjjm 4620 15 only only RB cord-023095-4dannjjm 4620 16 mean mean VBP cord-023095-4dannjjm 4620 17 glucose glucose NN cord-023095-4dannjjm 4620 18 ( ( -LRB- cord-023095-4dannjjm 4620 19 S S NNP cord-023095-4dannjjm 4620 20 5 5 CD cord-023095-4dannjjm 4620 21 131 131 CD cord-023095-4dannjjm 4620 22 mg mg NNP cord-023095-4dannjjm 4620 23 / / SYM cord-023095-4dannjjm 4620 24 dl dl NNP cord-023095-4dannjjm 4620 25 , , , cord-023095-4dannjjm 4621 1 NS NS NNP cord-023095-4dannjjm 4621 2 5 5 CD cord-023095-4dannjjm 4622 1 171.4 171.4 CD cord-023095-4dannjjm 4622 2 mg mg NNP cord-023095-4dannjjm 4622 3 / / SYM cord-023095-4dannjjm 4622 4 dl dl NNP cord-023095-4dannjjm 4622 5 , , , cord-023095-4dannjjm 4622 6 p p NN cord-023095-4dannjjm 4622 7 5 5 CD cord-023095-4dannjjm 4622 8 0.029 0.029 CD cord-023095-4dannjjm 4622 9 ) ) -RRB- cord-023095-4dannjjm 4622 10 was be VBD cord-023095-4dannjjm 4622 11 significantly significantly RB cord-023095-4dannjjm 4622 12 different different JJ cord-023095-4dannjjm 4622 13 between between IN cord-023095-4dannjjm 4622 14 groups group NNS cord-023095-4dannjjm 4622 15 , , , cord-023095-4dannjjm 4622 16 although although IN cord-023095-4dannjjm 4622 17 there there EX cord-023095-4dannjjm 4622 18 was be VBD cord-023095-4dannjjm 4622 19 a a DT cord-023095-4dannjjm 4622 20 trend trend NN cord-023095-4dannjjm 4622 21 for for IN cord-023095-4dannjjm 4622 22 a a DT cord-023095-4dannjjm 4622 23 difference difference NN cord-023095-4dannjjm 4622 24 in in IN cord-023095-4dannjjm 4622 25 mean mean JJ cord-023095-4dannjjm 4622 26 BE BE NNP cord-023095-4dannjjm 4622 27 ( ( -LRB- cord-023095-4dannjjm 4622 28 S s NN cord-023095-4dannjjm 4622 29 5 5 CD cord-023095-4dannjjm 4622 30 À3.6 À3.6 NNP cord-023095-4dannjjm 4622 31 , , , cord-023095-4dannjjm 4622 32 NS NS NNP cord-023095-4dannjjm 4622 33 5 5 CD cord-023095-4dannjjm 4623 1 À8,5 À8,5 NNP cord-023095-4dannjjm 4623 2 , , , cord-023095-4dannjjm 4623 3 p p NN cord-023095-4dannjjm 4623 4 5 5 CD cord-023095-4dannjjm 4623 5 0.055 0.055 CD cord-023095-4dannjjm 4623 6 ) ) -RRB- cord-023095-4dannjjm 4623 7 . . . cord-023095-4dannjjm 4624 1 Logistic logistic JJ cord-023095-4dannjjm 4624 2 regression regression NN cord-023095-4dannjjm 4624 3 analysis analysis NN cord-023095-4dannjjm 4624 4 showed show VBD cord-023095-4dannjjm 4624 5 that that DT cord-023095-4dannjjm 4624 6 of of IN cord-023095-4dannjjm 4624 7 the the DT cord-023095-4dannjjm 4624 8 parameters parameter NNS cord-023095-4dannjjm 4624 9 , , , cord-023095-4dannjjm 4624 10 only only RB cord-023095-4dannjjm 4624 11 BE BE NNP cord-023095-4dannjjm 4624 12 was be VBD cord-023095-4dannjjm 4624 13 independently independently RB cord-023095-4dannjjm 4624 14 associated associate VBN cord-023095-4dannjjm 4624 15 with with IN cord-023095-4dannjjm 4624 16 outcome outcome NN cord-023095-4dannjjm 4624 17 ( ( -LRB- cord-023095-4dannjjm 4624 18 odds odd NNS cord-023095-4dannjjm 4624 19 ratio ratio NN cord-023095-4dannjjm 4624 20 0.79 0.79 CD cord-023095-4dannjjm 4624 21 , , , cord-023095-4dannjjm 4624 22 95 95 CD cord-023095-4dannjjm 4624 23 % % NN cord-023095-4dannjjm 4624 24 CI CI NNP cord-023095-4dannjjm 4624 25 5 5 CD cord-023095-4dannjjm 4624 26 0.63 0.63 CD cord-023095-4dannjjm 4624 27 - - HYPH cord-023095-4dannjjm 4624 28 0.98 0.98 CD cord-023095-4dannjjm 4624 29 , , , cord-023095-4dannjjm 4624 30 p p NN cord-023095-4dannjjm 4624 31 5 5 CD cord-023095-4dannjjm 4624 32 0.036 0.036 CD cord-023095-4dannjjm 4624 33 ) ) -RRB- cord-023095-4dannjjm 4624 34 . . . cord-023095-4dannjjm 4625 1 These these DT cord-023095-4dannjjm 4625 2 results result NNS cord-023095-4dannjjm 4625 3 suggest suggest VBP cord-023095-4dannjjm 4625 4 that that IN cord-023095-4dannjjm 4625 5 two two CD cord-023095-4dannjjm 4625 6 easily easily RB cord-023095-4dannjjm 4625 7 measured measure VBD cord-023095-4dannjjm 4625 8 biochemical biochemical JJ cord-023095-4dannjjm 4625 9 parameters parameter NNS cord-023095-4dannjjm 4625 10 ( ( -LRB- cord-023095-4dannjjm 4625 11 glucose glucose NN cord-023095-4dannjjm 4625 12 and and CC cord-023095-4dannjjm 4625 13 BE be VB cord-023095-4dannjjm 4625 14 ) ) -RRB- cord-023095-4dannjjm 4625 15 may may MD cord-023095-4dannjjm 4625 16 yield yield VB cord-023095-4dannjjm 4625 17 useful useful JJ cord-023095-4dannjjm 4625 18 prognostic prognostic JJ cord-023095-4dannjjm 4625 19 information information NN cord-023095-4dannjjm 4625 20 in in IN cord-023095-4dannjjm 4625 21 dogs dog NNS cord-023095-4dannjjm 4625 22 with with IN cord-023095-4dannjjm 4625 23 head head NN cord-023095-4dannjjm 4625 24 trauma trauma NN cord-023095-4dannjjm 4625 25 , , , cord-023095-4dannjjm 4625 26 but but CC cord-023095-4dannjjm 4625 27 further further JJ cord-023095-4dannjjm 4625 28 studies study NNS cord-023095-4dannjjm 4625 29 are be VBP cord-023095-4dannjjm 4625 30 needed need VBN cord-023095-4dannjjm 4625 31 to to TO cord-023095-4dannjjm 4625 32 further further RB cord-023095-4dannjjm 4625 33 elucidate elucidate VB cord-023095-4dannjjm 4625 34 these these DT cord-023095-4dannjjm 4625 35 findings finding NNS cord-023095-4dannjjm 4625 36 . . . cord-023095-4dannjjm 4626 1 Type type NN cord-023095-4dannjjm 4626 2 I -PRON- PRP cord-023095-4dannjjm 4626 3 intervertebral intervertebral JJ cord-023095-4dannjjm 4626 4 disc disc NN cord-023095-4dannjjm 4626 5 disease disease NN cord-023095-4dannjjm 4626 6 ( ( -LRB- cord-023095-4dannjjm 4626 7 IVDD IVDD NNP cord-023095-4dannjjm 4626 8 ) ) -RRB- cord-023095-4dannjjm 4626 9 commonly commonly RB cord-023095-4dannjjm 4626 10 affects affect VBZ cord-023095-4dannjjm 4626 11 chondrodystrophic chondrodystrophic JJ cord-023095-4dannjjm 4626 12 dogs dog NNS cord-023095-4dannjjm 4626 13 . . . cord-023095-4dannjjm 4627 1 Neurological neurological JJ cord-023095-4dannjjm 4627 2 recovery recovery NN cord-023095-4dannjjm 4627 3 and and CC cord-023095-4dannjjm 4627 4 outcome outcome NN cord-023095-4dannjjm 4627 5 following follow VBG cord-023095-4dannjjm 4627 6 surgical surgical JJ cord-023095-4dannjjm 4627 7 decompression decompression NN cord-023095-4dannjjm 4627 8 may may MD cord-023095-4dannjjm 4627 9 be be VB cord-023095-4dannjjm 4627 10 unpredictable unpredictable JJ cord-023095-4dannjjm 4627 11 due due IN cord-023095-4dannjjm 4627 12 to to IN cord-023095-4dannjjm 4627 13 suspected suspect VBN cord-023095-4dannjjm 4627 14 ischemic ischemic JJ cord-023095-4dannjjm 4627 15 neuronal neuronal JJ cord-023095-4dannjjm 4627 16 injury injury NN cord-023095-4dannjjm 4627 17 . . . cord-023095-4dannjjm 4628 1 Hyperlactatemia Hyperlactatemia NNP cord-023095-4dannjjm 4628 2 has have VBZ cord-023095-4dannjjm 4628 3 been be VBN cord-023095-4dannjjm 4628 4 associated associate VBN cord-023095-4dannjjm 4628 5 with with IN cord-023095-4dannjjm 4628 6 spinal spinal JJ cord-023095-4dannjjm 4628 7 cord cord NN cord-023095-4dannjjm 4628 8 injury injury NN cord-023095-4dannjjm 4628 9 in in IN cord-023095-4dannjjm 4628 10 humans human NNS cord-023095-4dannjjm 4628 11 and and CC cord-023095-4dannjjm 4628 12 experimental experimental JJ cord-023095-4dannjjm 4628 13 animals animal NNS cord-023095-4dannjjm 4628 14 . . . cord-023095-4dannjjm 4629 1 The the DT cord-023095-4dannjjm 4629 2 purpose purpose NN cord-023095-4dannjjm 4629 3 of of IN cord-023095-4dannjjm 4629 4 the the DT cord-023095-4dannjjm 4629 5 study study NN cord-023095-4dannjjm 4629 6 was be VBD cord-023095-4dannjjm 4629 7 1 1 CD cord-023095-4dannjjm 4629 8 ) ) -RRB- cord-023095-4dannjjm 4629 9 to to TO cord-023095-4dannjjm 4629 10 determine determine VB cord-023095-4dannjjm 4629 11 the the DT cord-023095-4dannjjm 4629 12 relationship relationship NN cord-023095-4dannjjm 4629 13 between between IN cord-023095-4dannjjm 4629 14 serum serum NN cord-023095-4dannjjm 4629 15 and and CC cord-023095-4dannjjm 4629 16 CSF csf NN cord-023095-4dannjjm 4629 17 lactate lactate NN cord-023095-4dannjjm 4629 18 levels level NNS cord-023095-4dannjjm 4629 19 and and CC cord-023095-4dannjjm 4629 20 2 2 CD cord-023095-4dannjjm 4629 21 ) ) -RRB- cord-023095-4dannjjm 4629 22 to to TO cord-023095-4dannjjm 4629 23 compare compare VB cord-023095-4dannjjm 4629 24 lactate lactate NN cord-023095-4dannjjm 4629 25 levels level NNS cord-023095-4dannjjm 4629 26 with with IN cord-023095-4dannjjm 4629 27 neurological neurological JJ cord-023095-4dannjjm 4629 28 outcome outcome NN cord-023095-4dannjjm 4629 29 following follow VBG cord-023095-4dannjjm 4629 30 decompressive decompressive JJ cord-023095-4dannjjm 4629 31 surgery surgery NN cord-023095-4dannjjm 4629 32 in in IN cord-023095-4dannjjm 4629 33 dogs dog NNS cord-023095-4dannjjm 4629 34 with with IN cord-023095-4dannjjm 4629 35 IVDD IVDD NNP cord-023095-4dannjjm 4629 36 . . . cord-023095-4dannjjm 4630 1 Healthy healthy JJ cord-023095-4dannjjm 4630 2 , , , cord-023095-4dannjjm 4630 3 chondrodystrophic chondrodystrophic JJ cord-023095-4dannjjm 4630 4 dogs dog NNS cord-023095-4dannjjm 4630 5 diagnosed diagnose VBN cord-023095-4dannjjm 4630 6 with with IN cord-023095-4dannjjm 4630 7 IVDD IVDD NNP cord-023095-4dannjjm 4630 8 localized localize VBN cord-023095-4dannjjm 4630 9 to to IN cord-023095-4dannjjm 4630 10 the the DT cord-023095-4dannjjm 4630 11 T3-L3 T3-L3 NNP cord-023095-4dannjjm 4630 12 spinal spinal JJ cord-023095-4dannjjm 4630 13 cord cord NN cord-023095-4dannjjm 4630 14 were be VBD cord-023095-4dannjjm 4630 15 included include VBN cord-023095-4dannjjm 4630 16 . . . cord-023095-4dannjjm 4631 1 Serum serum NN cord-023095-4dannjjm 4631 2 lactate lactate NN cord-023095-4dannjjm 4631 3 levels level NNS cord-023095-4dannjjm 4631 4 were be VBD cord-023095-4dannjjm 4631 5 obtained obtain VBN cord-023095-4dannjjm 4631 6 at at IN cord-023095-4dannjjm 4631 7 : : : cord-023095-4dannjjm 4631 8 anaesthetic anaesthetic JJ cord-023095-4dannjjm 4631 9 induction induction NN cord-023095-4dannjjm 4631 10 , , , cord-023095-4dannjjm 4631 11 skin skin NN cord-023095-4dannjjm 4631 12 incision incision NN cord-023095-4dannjjm 4631 13 , , , cord-023095-4dannjjm 4631 14 muscle muscle NN cord-023095-4dannjjm 4631 15 dissection dissection NN cord-023095-4dannjjm 4631 16 , , , cord-023095-4dannjjm 4631 17 and and CC cord-023095-4dannjjm 4631 18 extubation extubation NN cord-023095-4dannjjm 4631 19 . . . cord-023095-4dannjjm 4632 1 In in IN cord-023095-4dannjjm 4632 2 patients patient NNS cord-023095-4dannjjm 4632 3 with with IN cord-023095-4dannjjm 4632 4 hyperlacatemia hyperlacatemia NN cord-023095-4dannjjm 4632 5 at at IN cord-023095-4dannjjm 4632 6 extubation extubation NN cord-023095-4dannjjm 4632 7 , , , cord-023095-4dannjjm 4632 8 additional additional JJ cord-023095-4dannjjm 4632 9 samples sample NNS cord-023095-4dannjjm 4632 10 were be VBD cord-023095-4dannjjm 4632 11 obtained obtain VBN cord-023095-4dannjjm 4632 12 . . . cord-023095-4dannjjm 4633 1 CSF CSF NNP cord-023095-4dannjjm 4633 2 was be VBD cord-023095-4dannjjm 4633 3 analyzed analyze VBN cord-023095-4dannjjm 4633 4 for for IN cord-023095-4dannjjm 4633 5 lactate lactate NN cord-023095-4dannjjm 4633 6 concentration concentration NN cord-023095-4dannjjm 4633 7 . . . cord-023095-4dannjjm 4634 1 Neurological neurological JJ cord-023095-4dannjjm 4634 2 status status NN cord-023095-4dannjjm 4634 3 was be VBD cord-023095-4dannjjm 4634 4 recorded record VBN cord-023095-4dannjjm 4634 5 at at IN cord-023095-4dannjjm 4634 6 presentation presentation NN cord-023095-4dannjjm 4634 7 and and CC cord-023095-4dannjjm 4634 8 multiple multiple JJ cord-023095-4dannjjm 4634 9 times time NNS cord-023095-4dannjjm 4634 10 during during IN cord-023095-4dannjjm 4634 11 the the DT cord-023095-4dannjjm 4634 12 recovery recovery NN cord-023095-4dannjjm 4634 13 period period NN cord-023095-4dannjjm 4634 14 . . . cord-023095-4dannjjm 4635 1 31 31 CD cord-023095-4dannjjm 4635 2 dogs dog NNS cord-023095-4dannjjm 4635 3 were be VBD cord-023095-4dannjjm 4635 4 included include VBN cord-023095-4dannjjm 4635 5 in in IN cord-023095-4dannjjm 4635 6 the the DT cord-023095-4dannjjm 4635 7 study study NN cord-023095-4dannjjm 4635 8 ( ( -LRB- cord-023095-4dannjjm 4635 9 3 3 CD cord-023095-4dannjjm 4635 10 - - SYM cord-023095-4dannjjm 4635 11 12 12 CD cord-023095-4dannjjm 4635 12 years year NNS cord-023095-4dannjjm 4635 13 old old JJ cord-023095-4dannjjm 4635 14 ) ) -RRB- cord-023095-4dannjjm 4635 15 . . . cord-023095-4dannjjm 4636 1 22/31 22/31 CD cord-023095-4dannjjm 4636 2 dogs dog NNS cord-023095-4dannjjm 4636 3 had have VBD cord-023095-4dannjjm 4636 4 normal normal JJ cord-023095-4dannjjm 4636 5 lactate lactate NN cord-023095-4dannjjm 4636 6 levels level NNS cord-023095-4dannjjm 4636 7 throughout throughout IN cord-023095-4dannjjm 4636 8 the the DT cord-023095-4dannjjm 4636 9 study study NN cord-023095-4dannjjm 4636 10 . . . cord-023095-4dannjjm 4637 1 9/31 9/31 CD cord-023095-4dannjjm 4637 2 dogs dog NNS cord-023095-4dannjjm 4637 3 had have VBD cord-023095-4dannjjm 4637 4 serum serum NN cord-023095-4dannjjm 4637 5 hyperlactatemia hyperlactatemia NN cord-023095-4dannjjm 4637 6 prior prior RB cord-023095-4dannjjm 4637 7 to to IN cord-023095-4dannjjm 4637 8 anaesthetic anaesthetic JJ cord-023095-4dannjjm 4637 9 induction induction NN cord-023095-4dannjjm 4637 10 ; ; : cord-023095-4dannjjm 4637 11 6/9 6/9 CD cord-023095-4dannjjm 4637 12 dogs dog NNS cord-023095-4dannjjm 4637 13 returned return VBD cord-023095-4dannjjm 4637 14 to to IN cord-023095-4dannjjm 4637 15 normal normal JJ cord-023095-4dannjjm 4637 16 during during IN cord-023095-4dannjjm 4637 17 anaesthesia anaesthesia NN cord-023095-4dannjjm 4637 18 and and CC cord-023095-4dannjjm 4637 19 3/9 3/9 CD cord-023095-4dannjjm 4637 20 dogs dog NNS cord-023095-4dannjjm 4637 21 had have VBD cord-023095-4dannjjm 4637 22 continued continue VBN cord-023095-4dannjjm 4637 23 hyperlactatemia hyperlactatemia NN cord-023095-4dannjjm 4637 24 until until IN cord-023095-4dannjjm 4637 25 the the DT cord-023095-4dannjjm 4637 26 end end NN cord-023095-4dannjjm 4637 27 of of IN cord-023095-4dannjjm 4637 28 the the DT cord-023095-4dannjjm 4637 29 observation observation NN cord-023095-4dannjjm 4637 30 period period NN cord-023095-4dannjjm 4637 31 . . . cord-023095-4dannjjm 4638 1 Neurological neurological JJ cord-023095-4dannjjm 4638 2 status status NN cord-023095-4dannjjm 4638 3 of of IN cord-023095-4dannjjm 4638 4 the the DT cord-023095-4dannjjm 4638 5 dogs dog NNS cord-023095-4dannjjm 4638 6 varied vary VBN cord-023095-4dannjjm 4638 7 similarly similarly RB cord-023095-4dannjjm 4638 8 between between IN cord-023095-4dannjjm 4638 9 all all DT cord-023095-4dannjjm 4638 10 groups group NNS cord-023095-4dannjjm 4638 11 . . . cord-023095-4dannjjm 4639 1 In in IN cord-023095-4dannjjm 4639 2 12/14 12/14 CD cord-023095-4dannjjm 4639 3 dogs dog NNS cord-023095-4dannjjm 4639 4 where where WRB cord-023095-4dannjjm 4639 5 CSF csf NN cord-023095-4dannjjm 4639 6 lactate lactate NN cord-023095-4dannjjm 4639 7 levels level NNS cord-023095-4dannjjm 4639 8 were be VBD cord-023095-4dannjjm 4639 9 measured measure VBN cord-023095-4dannjjm 4639 10 , , , cord-023095-4dannjjm 4639 11 initial initial JJ cord-023095-4dannjjm 4639 12 serum serum NN cord-023095-4dannjjm 4639 13 levels level NNS cord-023095-4dannjjm 4639 14 were be VBD cord-023095-4dannjjm 4639 15 lower low JJR cord-023095-4dannjjm 4639 16 than than IN cord-023095-4dannjjm 4639 17 CSF csf NN cord-023095-4dannjjm 4639 18 lactate lactate NN cord-023095-4dannjjm 4639 19 levels level NNS cord-023095-4dannjjm 4639 20 ; ; : cord-023095-4dannjjm 4639 21 in in IN cord-023095-4dannjjm 4639 22 5/14 5/14 CD cord-023095-4dannjjm 4639 23 dogs dog NNS cord-023095-4dannjjm 4639 24 where where WRB cord-023095-4dannjjm 4639 25 CSF CSF NNP cord-023095-4dannjjm 4639 26 and and CC cord-023095-4dannjjm 4639 27 serum serum NN cord-023095-4dannjjm 4639 28 were be VBD cord-023095-4dannjjm 4639 29 collected collect VBN cord-023095-4dannjjm 4639 30 simultaneously simultaneously RB cord-023095-4dannjjm 4639 31 , , , cord-023095-4dannjjm 4639 32 serum serum NN cord-023095-4dannjjm 4639 33 lactate lactate NN cord-023095-4dannjjm 4639 34 concentration concentration NN cord-023095-4dannjjm 4639 35 was be VBD cord-023095-4dannjjm 4639 36 consistently consistently RB cord-023095-4dannjjm 4639 37 lower low JJR cord-023095-4dannjjm 4639 38 than than IN cord-023095-4dannjjm 4639 39 CSF CSF NNP cord-023095-4dannjjm 4639 40 lactate lactate NN cord-023095-4dannjjm 4639 41 . . . cord-023095-4dannjjm 4640 1 No no DT cord-023095-4dannjjm 4640 2 association association NN cord-023095-4dannjjm 4640 3 between between IN cord-023095-4dannjjm 4640 4 presenting present VBG cord-023095-4dannjjm 4640 5 neurological neurological JJ cord-023095-4dannjjm 4640 6 status status NN cord-023095-4dannjjm 4640 7 or or CC cord-023095-4dannjjm 4640 8 neurological neurological JJ cord-023095-4dannjjm 4640 9 outcome outcome NN cord-023095-4dannjjm 4640 10 and and CC cord-023095-4dannjjm 4640 11 serum serum NN cord-023095-4dannjjm 4640 12 or or CC cord-023095-4dannjjm 4640 13 CSF CSF NNP cord-023095-4dannjjm 4640 14 lactate lactate NN cord-023095-4dannjjm 4640 15 concentration concentration NN cord-023095-4dannjjm 4640 16 was be VBD cord-023095-4dannjjm 4640 17 made make VBN cord-023095-4dannjjm 4640 18 . . . cord-023095-4dannjjm 4641 1 Neither neither DT cord-023095-4dannjjm 4641 2 serum serum NN cord-023095-4dannjjm 4641 3 nor nor CC cord-023095-4dannjjm 4641 4 CSF csf NN cord-023095-4dannjjm 4641 5 lactate lactate NN cord-023095-4dannjjm 4641 6 concentration concentration NN cord-023095-4dannjjm 4641 7 is be VBZ cord-023095-4dannjjm 4641 8 useful useful JJ cord-023095-4dannjjm 4641 9 for for IN cord-023095-4dannjjm 4641 10 predicting predict VBG cord-023095-4dannjjm 4641 11 neurological neurological JJ cord-023095-4dannjjm 4641 12 outcome outcome NN cord-023095-4dannjjm 4641 13 in in IN cord-023095-4dannjjm 4641 14 dogs dog NNS cord-023095-4dannjjm 4641 15 with with IN cord-023095-4dannjjm 4641 16 IVDD IVDD NNP cord-023095-4dannjjm 4641 17 . . . cord-023095-4dannjjm 4642 1 Chiari Chiari NNP cord-023095-4dannjjm 4642 2 - - HYPH cord-023095-4dannjjm 4642 3 like like JJ cord-023095-4dannjjm 4642 4 Malformation Malformation NNP cord-023095-4dannjjm 4642 5 ( ( -LRB- cord-023095-4dannjjm 4642 6 CM CM NNP cord-023095-4dannjjm 4642 7 ) ) -RRB- cord-023095-4dannjjm 4642 8 has have VBZ cord-023095-4dannjjm 4642 9 been be VBN cord-023095-4dannjjm 4642 10 associated associate VBN cord-023095-4dannjjm 4642 11 with with IN cord-023095-4dannjjm 4642 12 syringomyelia syringomyelia NN cord-023095-4dannjjm 4642 13 ( ( -LRB- cord-023095-4dannjjm 4642 14 SM SM NNP cord-023095-4dannjjm 4642 15 ) ) -RRB- cord-023095-4dannjjm 4642 16 in in IN cord-023095-4dannjjm 4642 17 Cavalier Cavalier NNP cord-023095-4dannjjm 4642 18 King King NNP cord-023095-4dannjjm 4642 19 Charles Charles NNP cord-023095-4dannjjm 4642 20 Spaniel Spaniel NNP cord-023095-4dannjjm 4642 21 ( ( -LRB- cord-023095-4dannjjm 4642 22 CKCS CKCS NNP cord-023095-4dannjjm 4642 23 ) ) -RRB- cord-023095-4dannjjm 4642 24 and and CC cord-023095-4dannjjm 4642 25 is be VBZ cord-023095-4dannjjm 4642 26 postulated postulate VBN cord-023095-4dannjjm 4642 27 to to TO cord-023095-4dannjjm 4642 28 result result VB cord-023095-4dannjjm 4642 29 from from IN cord-023095-4dannjjm 4642 30 a a DT cord-023095-4dannjjm 4642 31 mismatch mismatch NN cord-023095-4dannjjm 4642 32 between between IN cord-023095-4dannjjm 4642 33 the the DT cord-023095-4dannjjm 4642 34 volume volume NN cord-023095-4dannjjm 4642 35 of of IN cord-023095-4dannjjm 4642 36 the the DT cord-023095-4dannjjm 4642 37 caudal caudal JJ cord-023095-4dannjjm 4642 38 cranial cranial JJ cord-023095-4dannjjm 4642 39 fossa fossa NN cord-023095-4dannjjm 4642 40 and and CC cord-023095-4dannjjm 4642 41 the the DT cord-023095-4dannjjm 4642 42 brain brain NN cord-023095-4dannjjm 4642 43 parenchyma parenchyma NNS cord-023095-4dannjjm 4642 44 contained contain VBN cord-023095-4dannjjm 4642 45 within within IN cord-023095-4dannjjm 4642 46 . . . cord-023095-4dannjjm 4643 1 The the DT cord-023095-4dannjjm 4643 2 objective objective NN cord-023095-4dannjjm 4643 3 of of IN cord-023095-4dannjjm 4643 4 this this DT cord-023095-4dannjjm 4643 5 study study NN cord-023095-4dannjjm 4643 6 was be VBD cord-023095-4dannjjm 4643 7 to to TO cord-023095-4dannjjm 4643 8 assess assess VB cord-023095-4dannjjm 4643 9 the the DT cord-023095-4dannjjm 4643 10 role role NN cord-023095-4dannjjm 4643 11 of of IN cord-023095-4dannjjm 4643 12 cerebellar cerebellar JJ cord-023095-4dannjjm 4643 13 volume volume NN cord-023095-4dannjjm 4643 14 in in IN cord-023095-4dannjjm 4643 15 caudal caudal JJ cord-023095-4dannjjm 4643 16 cranial cranial JJ cord-023095-4dannjjm 4643 17 fossa fossa NN cord-023095-4dannjjm 4643 18 overcrowding overcrowding NN cord-023095-4dannjjm 4643 19 and and CC cord-023095-4dannjjm 4643 20 syringomyelia syringomyelia NN cord-023095-4dannjjm 4643 21 . . . cord-023095-4dannjjm 4644 1 Three three CD cord-023095-4dannjjm 4644 2 dimensional dimensional JJ cord-023095-4dannjjm 4644 3 models model NNS cord-023095-4dannjjm 4644 4 were be VBD cord-023095-4dannjjm 4644 5 created create VBN cord-023095-4dannjjm 4644 6 using use VBG cord-023095-4dannjjm 4644 7 T2-weighted t2-weighte VBN cord-023095-4dannjjm 4644 8 transverse transverse JJ cord-023095-4dannjjm 4644 9 magnetic magnetic JJ cord-023095-4dannjjm 4644 10 resonance resonance NN cord-023095-4dannjjm 4644 11 images image NNS cord-023095-4dannjjm 4644 12 in in IN cord-023095-4dannjjm 4644 13 the the DT cord-023095-4dannjjm 4644 14 commercial commercial JJ cord-023095-4dannjjm 4644 15 software software NN cord-023095-4dannjjm 4644 16 package package NN cord-023095-4dannjjm 4644 17 Mimics mimic VBZ cord-023095-4dannjjm 4644 18 s s NNP cord-023095-4dannjjm 4644 19 . . . cord-023095-4dannjjm 4645 1 Volumes volume NNS cord-023095-4dannjjm 4645 2 of of IN cord-023095-4dannjjm 4645 3 cerebellar cerebellar JJ cord-023095-4dannjjm 4645 4 parenchyma parenchyma NNS cord-023095-4dannjjm 4645 5 were be VBD cord-023095-4dannjjm 4645 6 analyzed analyze VBN cord-023095-4dannjjm 4645 7 as as IN cord-023095-4dannjjm 4645 8 percentages percentage NNS cord-023095-4dannjjm 4645 9 of of IN cord-023095-4dannjjm 4645 10 caudal caudal JJ cord-023095-4dannjjm 4645 11 cranial cranial JJ cord-023095-4dannjjm 4645 12 fossa fossa NN cord-023095-4dannjjm 4645 13 volume volume NN cord-023095-4dannjjm 4645 14 ( ( -LRB- cord-023095-4dannjjm 4645 15 cerebellar cerebellar JJ cord-023095-4dannjjm 4645 16 caudal caudal JJ cord-023095-4dannjjm 4645 17 cranial cranial JJ cord-023095-4dannjjm 4645 18 fossa fossa NN cord-023095-4dannjjm 4645 19 percentage percentage NN cord-023095-4dannjjm 4645 20 ) ) -RRB- cord-023095-4dannjjm 4645 21 and and CC cord-023095-4dannjjm 4645 22 total total JJ cord-023095-4dannjjm 4645 23 brain brain NN cord-023095-4dannjjm 4645 24 parenchyma parenchyma NN cord-023095-4dannjjm 4645 25 volume volume NN cord-023095-4dannjjm 4645 26 ( ( -LRB- cord-023095-4dannjjm 4645 27 cerebellar cerebellar JJ cord-023095-4dannjjm 4645 28 brain brain NN cord-023095-4dannjjm 4645 29 percentage percentage NN cord-023095-4dannjjm 4645 30 ) ) -RRB- cord-023095-4dannjjm 4645 31 . . . cord-023095-4dannjjm 4646 1 Data datum NNS cord-023095-4dannjjm 4646 2 was be VBD cord-023095-4dannjjm 4646 3 assessed assess VBN cord-023095-4dannjjm 4646 4 for for IN cord-023095-4dannjjm 4646 5 normality normality NN cord-023095-4dannjjm 4646 6 and and CC cord-023095-4dannjjm 4646 7 the the DT cord-023095-4dannjjm 4646 8 appropriate appropriate JJ cord-023095-4dannjjm 4646 9 statistical statistical JJ cord-023095-4dannjjm 4646 10 test test NN cord-023095-4dannjjm 4646 11 was be VBD cord-023095-4dannjjm 4646 12 used use VBN cord-023095-4dannjjm 4646 13 to to TO cord-023095-4dannjjm 4646 14 compare compare VB cord-023095-4dannjjm 4646 15 means mean NNS cord-023095-4dannjjm 4646 16 / / SYM cord-023095-4dannjjm 4646 17 medians median NNS cord-023095-4dannjjm 4646 18 between between IN cord-023095-4dannjjm 4646 19 groups group NNS cord-023095-4dannjjm 4646 20 . . . cord-023095-4dannjjm 4647 1 Forty forty CD cord-023095-4dannjjm 4647 2 - - HYPH cord-023095-4dannjjm 4647 3 five five CD cord-023095-4dannjjm 4647 4 small small JJ cord-023095-4dannjjm 4647 5 breed breed NN cord-023095-4dannjjm 4647 6 dogs dog NNS cord-023095-4dannjjm 4647 7 ( ( -LRB- cord-023095-4dannjjm 4647 8 SB SB NNP cord-023095-4dannjjm 4647 9 ) ) -RRB- cord-023095-4dannjjm 4647 10 , , , cord-023095-4dannjjm 4647 11 58 58 CD cord-023095-4dannjjm 4647 12 CKCS CKCS NNP cord-023095-4dannjjm 4647 13 and and CC cord-023095-4dannjjm 4647 14 31 31 CD cord-023095-4dannjjm 4647 15 Labradors labrador NNS cord-023095-4dannjjm 4647 16 ( ( -LRB- cord-023095-4dannjjm 4647 17 LD LD NNP cord-023095-4dannjjm 4647 18 ) ) -RRB- cord-023095-4dannjjm 4647 19 were be VBD cord-023095-4dannjjm 4647 20 compared compare VBN cord-023095-4dannjjm 4647 21 . . . cord-023095-4dannjjm 4648 1 As as IN cord-023095-4dannjjm 4648 2 SM SM NNP cord-023095-4dannjjm 4648 3 is be VBZ cord-023095-4dannjjm 4648 4 thought think VBN cord-023095-4dannjjm 4648 5 to to TO cord-023095-4dannjjm 4648 6 be be VB cord-023095-4dannjjm 4648 7 a a DT cord-023095-4dannjjm 4648 8 late late JJ cord-023095-4dannjjm 4648 9 onset onset NN cord-023095-4dannjjm 4648 10 disease disease NN cord-023095-4dannjjm 4648 11 process process NN cord-023095-4dannjjm 4648 12 , , , cord-023095-4dannjjm 4648 13 two two CD cord-023095-4dannjjm 4648 14 subgroups subgroup NNS cord-023095-4dannjjm 4648 15 were be VBD cord-023095-4dannjjm 4648 16 formed form VBN cord-023095-4dannjjm 4648 17 for for IN cord-023095-4dannjjm 4648 18 comparison comparison NN cord-023095-4dannjjm 4648 19 : : : cord-023095-4dannjjm 4649 1 21 21 CD cord-023095-4dannjjm 4649 2 CKCS CKCS NNP cord-023095-4dannjjm 4649 3 younger young JJR cord-023095-4dannjjm 4649 4 than than IN cord-023095-4dannjjm 4649 5 2 2 CD cord-023095-4dannjjm 4649 6 years year NNS cord-023095-4dannjjm 4649 7 with with IN cord-023095-4dannjjm 4649 8 SM SM NNP cord-023095-4dannjjm 4649 9 ( ( -LRB- cord-023095-4dannjjm 4649 10 group group NN cord-023095-4dannjjm 4649 11 1 1 CD cord-023095-4dannjjm 4649 12 ) ) -RRB- cord-023095-4dannjjm 4649 13 and and CC cord-023095-4dannjjm 4650 1 13 13 CD cord-023095-4dannjjm 4650 2 CKCS CKCS NNP cord-023095-4dannjjm 4650 3 older old JJR cord-023095-4dannjjm 4650 4 than than IN cord-023095-4dannjjm 4650 5 5 5 CD cord-023095-4dannjjm 4650 6 years year NNS cord-023095-4dannjjm 4650 7 without without IN cord-023095-4dannjjm 4650 8 SM SM NNP cord-023095-4dannjjm 4650 9 ( ( -LRB- cord-023095-4dannjjm 4650 10 group group NN cord-023095-4dannjjm 4650 11 2 2 CD cord-023095-4dannjjm 4650 12 ) ) -RRB- cord-023095-4dannjjm 4650 13 . . . cord-023095-4dannjjm 4651 1 CKCS CKCS NNP cord-023095-4dannjjm 4651 2 had have VBD cord-023095-4dannjjm 4651 3 a a DT cord-023095-4dannjjm 4651 4 larger large JJR cord-023095-4dannjjm 4651 5 cerebellar cerebellar JJ cord-023095-4dannjjm 4651 6 caudal caudal JJ cord-023095-4dannjjm 4651 7 cranial cranial JJ cord-023095-4dannjjm 4651 8 fossa fossa NN cord-023095-4dannjjm 4651 9 percentage percentage NN cord-023095-4dannjjm 4651 10 than than IN cord-023095-4dannjjm 4651 11 the the DT cord-023095-4dannjjm 4651 12 other other JJ cord-023095-4dannjjm 4651 13 groups group NNS cord-023095-4dannjjm 4651 14 .76 .76 CD cord-023095-4dannjjm 4651 15 % % NN cord-023095-4dannjjm 4651 16 ] ] -RRB- cord-023095-4dannjjm 4651 17 vs. vs. FW cord-023095-4dannjjm 4651 18 SB SB NNP cord-023095-4dannjjm 4651 19 47.81 47.81 CD cord-023095-4dannjjm 4651 20 % % NN cord-023095-4dannjjm 4651 21 [ [ -LRB- cord-023095-4dannjjm 4651 22 40.36 40.36 CD cord-023095-4dannjjm 4651 23 - - SYM cord-023095-4dannjjm 4651 24 62.91 62.91 CD cord-023095-4dannjjm 4651 25 % % NN cord-023095-4dannjjm 4651 26 ] ] -RRB- cord-023095-4dannjjm 4651 27 and and CC cord-023095-4dannjjm 4651 28 LD LD NNP cord-023095-4dannjjm 4651 29 41.32 41.32 CD cord-023095-4dannjjm 4651 30 % % NN cord-023095-4dannjjm 4651 31 [ [ -LRB- cord-023095-4dannjjm 4651 32 32.59 32.59 CD cord-023095-4dannjjm 4651 33 - - SYM cord-023095-4dannjjm 4651 34 52.95 52.95 CD cord-023095-4dannjjm 4651 35 % % NN cord-023095-4dannjjm 4651 36 ] ] -RRB- cord-023095-4dannjjm 4651 37 ; ; : cord-023095-4dannjjm 4651 38 p p NN cord-023095-4dannjjm 4651 39 o o CD cord-023095-4dannjjm 4651 40 0.001 0.001 CD cord-023095-4dannjjm 4651 41 ) ) -RRB- cord-023095-4dannjjm 4651 42 . . . cord-023095-4dannjjm 4652 1 The the DT cord-023095-4dannjjm 4652 2 cerebellar cerebellar JJ cord-023095-4dannjjm 4652 3 brain brain NN cord-023095-4dannjjm 4652 4 percentage percentage NN cord-023095-4dannjjm 4652 5 was be VBD cord-023095-4dannjjm 4652 6 also also RB cord-023095-4dannjjm 4652 7 larger large JJR cord-023095-4dannjjm 4652 8 in in IN cord-023095-4dannjjm 4652 9 CKCS CKCS NNP cord-023095-4dannjjm 4652 10 compared compare VBN cord-023095-4dannjjm 4652 11 to to IN cord-023095-4dannjjm 4652 12 the the DT cord-023095-4dannjjm 4652 13 other other JJ cord-023095-4dannjjm 4652 14 groups group NNS cord-023095-4dannjjm 4652 15 ( ( -LRB- cord-023095-4dannjjm 4652 16 CKCS CKCS NNP cord-023095-4dannjjm 4652 17 8.90 8.90 CD cord-023095-4dannjjm 4652 18 % % NN cord-023095-4dannjjm 4652 19 [ [ -LRB- cord-023095-4dannjjm 4652 20 6.62 6.62 CD cord-023095-4dannjjm 4652 21 - - SYM cord-023095-4dannjjm 4652 22 11.46 11.46 CD cord-023095-4dannjjm 4652 23 % % NN cord-023095-4dannjjm 4652 24 ] ] -RRB- cord-023095-4dannjjm 4652 25 vs. vs. FW cord-023095-4dannjjm 4652 26 SB SB NNP cord-023095-4dannjjm 4652 27 7.37 7.37 CD cord-023095-4dannjjm 4652 28 % % NN cord-023095-4dannjjm 4652 29 [ [ -LRB- cord-023095-4dannjjm 4652 30 5.25 5.25 CD cord-023095-4dannjjm 4652 31 - - SYM cord-023095-4dannjjm 4652 32 11.34 11.34 CD cord-023095-4dannjjm 4652 33 % % NN cord-023095-4dannjjm 4652 34 ] ] -RRB- cord-023095-4dannjjm 4652 35 and and CC cord-023095-4dannjjm 4652 36 LD LD NNP cord-023095-4dannjjm 4652 37 7.23 7.23 CD cord-023095-4dannjjm 4652 38 % % NN cord-023095-4dannjjm 4652 39 [ [ -LRB- cord-023095-4dannjjm 4652 40 6.36 6.36 CD cord-023095-4dannjjm 4652 41 - - SYM cord-023095-4dannjjm 4652 42 9.54 9.54 CD cord-023095-4dannjjm 4652 43 % % NN cord-023095-4dannjjm 4652 44 ] ] -RRB- cord-023095-4dannjjm 4652 45 ; ; . cord-023095-4dannjjm 4653 1 p p NN cord-023095-4dannjjm 4653 2 o o NN cord-023095-4dannjjm 4653 3 0.001 0.001 CD cord-023095-4dannjjm 4653 4 ) ) -RRB- cord-023095-4dannjjm 4653 5 . . . cord-023095-4dannjjm 4654 1 Group group NN cord-023095-4dannjjm 4654 2 1 1 CD cord-023095-4dannjjm 4654 3 had have VBD cord-023095-4dannjjm 4654 4 a a DT cord-023095-4dannjjm 4654 5 significantly significantly RB cord-023095-4dannjjm 4654 6 larger large JJR cord-023095-4dannjjm 4654 7 cerebellar cerebellar JJ cord-023095-4dannjjm 4654 8 caudal caudal JJ cord-023095-4dannjjm 4654 9 cranial cranial JJ cord-023095-4dannjjm 4654 10 fossa fossa NN cord-023095-4dannjjm 4654 11 percentage percentage NN cord-023095-4dannjjm 4654 12 than than IN cord-023095-4dannjjm 4654 13 group group NN cord-023095-4dannjjm 4654 14 2 2 CD cord-023095-4dannjjm 4654 15 ( ( -LRB- cord-023095-4dannjjm 4654 16 53.71 53.71 CD cord-023095-4dannjjm 4654 17 % % NN cord-023095-4dannjjm 4654 18 AE AE NNP cord-023095-4dannjjm 4654 19 1.27 1.27 CD cord-023095-4dannjjm 4654 20 vs. vs. NN cord-023095-4dannjjm 4654 21 49.31 49.31 CD cord-023095-4dannjjm 4654 22 % % NN cord-023095-4dannjjm 4654 23 AE AE NNP cord-023095-4dannjjm 4654 24 2.35 2.35 CD cord-023095-4dannjjm 4654 25 , , , cord-023095-4dannjjm 4654 26 p p NN cord-023095-4dannjjm 4654 27 5 5 CD cord-023095-4dannjjm 4654 28 0.001 0.001 CD cord-023095-4dannjjm 4654 29 ) ) -RRB- cord-023095-4dannjjm 4654 30 and and CC cord-023095-4dannjjm 4654 31 a a DT cord-023095-4dannjjm 4654 32 significantly significantly RB cord-023095-4dannjjm 4654 33 larger large JJR cord-023095-4dannjjm 4654 34 cerebellar cerebellar JJ cord-023095-4dannjjm 4654 35 brain brain NN cord-023095-4dannjjm 4654 36 percentage percentage NN cord-023095-4dannjjm 4654 37 ( ( -LRB- cord-023095-4dannjjm 4654 38 9.45 9.45 CD cord-023095-4dannjjm 4654 39 % % NN cord-023095-4dannjjm 4654 40 AE AE NNP cord-023095-4dannjjm 4654 41 0.43 0.43 CD cord-023095-4dannjjm 4654 42 vs. vs. IN cord-023095-4dannjjm 4654 43 8.58 8.58 CD cord-023095-4dannjjm 4654 44 % % NN cord-023095-4dannjjm 4654 45 AE AE NNP cord-023095-4dannjjm 4654 46 0.55 0.55 CD cord-023095-4dannjjm 4654 47 , , , cord-023095-4dannjjm 4654 48 p p NN cord-023095-4dannjjm 4654 49 5 5 CD cord-023095-4dannjjm 4654 50 0.021 0.021 CD cord-023095-4dannjjm 4654 51 ) ) -RRB- cord-023095-4dannjjm 4654 52 . . . cord-023095-4dannjjm 4655 1 Our -PRON- PRP$ cord-023095-4dannjjm 4655 2 findings finding NNS cord-023095-4dannjjm 4655 3 show show VBP cord-023095-4dannjjm 4655 4 that that IN cord-023095-4dannjjm 4655 5 the the DT cord-023095-4dannjjm 4655 6 CKCS CKCS NNP cord-023095-4dannjjm 4655 7 has have VBZ cord-023095-4dannjjm 4655 8 a a DT cord-023095-4dannjjm 4655 9 relatively relatively RB cord-023095-4dannjjm 4655 10 larger large JJR cord-023095-4dannjjm 4655 11 cerebellum cerebellum NN cord-023095-4dannjjm 4655 12 than than IN cord-023095-4dannjjm 4655 13 small small JJ cord-023095-4dannjjm 4655 14 breed breed NN cord-023095-4dannjjm 4655 15 dogs dog NNS cord-023095-4dannjjm 4655 16 and and CC cord-023095-4dannjjm 4655 17 Labradors Labradors NNPS cord-023095-4dannjjm 4655 18 and and CC cord-023095-4dannjjm 4655 19 there there EX cord-023095-4dannjjm 4655 20 is be VBZ cord-023095-4dannjjm 4655 21 an an DT cord-023095-4dannjjm 4655 22 association association NN cord-023095-4dannjjm 4655 23 between between IN cord-023095-4dannjjm 4655 24 increased increase VBN cord-023095-4dannjjm 4655 25 cerebellar cerebellar JJ cord-023095-4dannjjm 4655 26 volume volume NN cord-023095-4dannjjm 4655 27 and and CC cord-023095-4dannjjm 4655 28 SM SM NNP cord-023095-4dannjjm 4655 29 in in IN cord-023095-4dannjjm 4655 30 CKCS CKCS NNP cord-023095-4dannjjm 4655 31 . . . cord-023095-4dannjjm 4656 1 Chiari Chiari NNP cord-023095-4dannjjm 4656 2 - - HYPH cord-023095-4dannjjm 4656 3 like like JJ cord-023095-4dannjjm 4656 4 malformation malformation NN cord-023095-4dannjjm 4656 5 ( ( -LRB- cord-023095-4dannjjm 4656 6 CM CM NNP cord-023095-4dannjjm 4656 7 ) ) -RRB- cord-023095-4dannjjm 4656 8 is be VBZ cord-023095-4dannjjm 4656 9 nearly nearly RB cord-023095-4dannjjm 4656 10 omnipresent omnipresent JJ cord-023095-4dannjjm 4656 11 in in IN cord-023095-4dannjjm 4656 12 the the DT cord-023095-4dannjjm 4656 13 Cavalier Cavalier NNP cord-023095-4dannjjm 4656 14 King King NNP cord-023095-4dannjjm 4656 15 Charles Charles NNP cord-023095-4dannjjm 4656 16 Spaniel Spaniel NNP cord-023095-4dannjjm 4656 17 ( ( -LRB- cord-023095-4dannjjm 4656 18 CKCS CKCS NNP cord-023095-4dannjjm 4656 19 ) ) -RRB- cord-023095-4dannjjm 4656 20 breed breed NN cord-023095-4dannjjm 4656 21 . . . cord-023095-4dannjjm 4657 1 The the DT cord-023095-4dannjjm 4657 2 mis mis NN cord-023095-4dannjjm 4657 3 - - HYPH cord-023095-4dannjjm 4657 4 match match NN cord-023095-4dannjjm 4657 5 of of IN cord-023095-4dannjjm 4657 6 the the DT cord-023095-4dannjjm 4657 7 caudal caudal JJ cord-023095-4dannjjm 4657 8 cranial cranial JJ cord-023095-4dannjjm 4657 9 fossa fossa NN cord-023095-4dannjjm 4657 10 and and CC cord-023095-4dannjjm 4657 11 the the DT cord-023095-4dannjjm 4657 12 parenchyma parenchyma NN cord-023095-4dannjjm 4657 13 within within RB cord-023095-4dannjjm 4657 14 is be VBZ cord-023095-4dannjjm 4657 15 thought think VBN cord-023095-4dannjjm 4657 16 to to TO cord-023095-4dannjjm 4657 17 lead lead VB cord-023095-4dannjjm 4657 18 to to IN cord-023095-4dannjjm 4657 19 syringomyelia syringomyelia NN cord-023095-4dannjjm 4657 20 ( ( -LRB- cord-023095-4dannjjm 4657 21 SM SM NNP cord-023095-4dannjjm 4657 22 ) ) -RRB- cord-023095-4dannjjm 4657 23 . . . cord-023095-4dannjjm 4658 1 There there EX cord-023095-4dannjjm 4658 2 is be VBZ cord-023095-4dannjjm 4658 3 currently currently RB cord-023095-4dannjjm 4658 4 a a DT cord-023095-4dannjjm 4658 5 lack lack NN cord-023095-4dannjjm 4658 6 of of IN cord-023095-4dannjjm 4658 7 information information NN cord-023095-4dannjjm 4658 8 if if IN cord-023095-4dannjjm 4658 9 the the DT cord-023095-4dannjjm 4658 10 morphological morphological JJ cord-023095-4dannjjm 4658 11 changes change NNS cord-023095-4dannjjm 4658 12 seen see VBN cord-023095-4dannjjm 4658 13 in in IN cord-023095-4dannjjm 4658 14 CKCS CKCS NNP cord-023095-4dannjjm 4658 15 with with IN cord-023095-4dannjjm 4658 16 CM CM NNP cord-023095-4dannjjm 4658 17 are be VBP cord-023095-4dannjjm 4658 18 progressive progressive JJ cord-023095-4dannjjm 4658 19 or or CC cord-023095-4dannjjm 4658 20 non non JJ cord-023095-4dannjjm 4658 21 - - JJ cord-023095-4dannjjm 4658 22 progressive progressive JJ cord-023095-4dannjjm 4658 23 . . . cord-023095-4dannjjm 4659 1 In in IN cord-023095-4dannjjm 4659 2 this this DT cord-023095-4dannjjm 4659 3 retrospective retrospective JJ cord-023095-4dannjjm 4659 4 study study NN cord-023095-4dannjjm 4659 5 we -PRON- PRP cord-023095-4dannjjm 4659 6 used use VBD cord-023095-4dannjjm 4659 7 established establish VBD cord-023095-4dannjjm 4659 8 measurements measurement NNS cord-023095-4dannjjm 4659 9 of of IN cord-023095-4dannjjm 4659 10 cerebral cerebral JJ cord-023095-4dannjjm 4659 11 volumes volume NNS cord-023095-4dannjjm 4659 12 , , , cord-023095-4dannjjm 4659 13 foramen foramen NNP cord-023095-4dannjjm 4659 14 magnum magnum NNP cord-023095-4dannjjm 4659 15 height height NN cord-023095-4dannjjm 4659 16 and and CC cord-023095-4dannjjm 4659 17 cerebellar cerebellar JJ cord-023095-4dannjjm 4659 18 herniation herniation NN cord-023095-4dannjjm 4659 19 length length NN cord-023095-4dannjjm 4659 20 to to TO cord-023095-4dannjjm 4659 21 assess assess VB cord-023095-4dannjjm 4659 22 if if IN cord-023095-4dannjjm 4659 23 there there EX cord-023095-4dannjjm 4659 24 is be VBZ cord-023095-4dannjjm 4659 25 a a DT cord-023095-4dannjjm 4659 26 significant significant JJ cord-023095-4dannjjm 4659 27 difference difference NN cord-023095-4dannjjm 4659 28 between between IN cord-023095-4dannjjm 4659 29 subsequent subsequent JJ cord-023095-4dannjjm 4659 30 magnetic magnetic JJ cord-023095-4dannjjm 4659 31 resonance resonance NN cord-023095-4dannjjm 4659 32 ( ( -LRB- cord-023095-4dannjjm 4659 33 MR MR NNP cord-023095-4dannjjm 4659 34 ) ) -RRB- cord-023095-4dannjjm 4659 35 imaging imaging NN cord-023095-4dannjjm 4659 36 of of IN cord-023095-4dannjjm 4659 37 the the DT cord-023095-4dannjjm 4659 38 brain brain NN cord-023095-4dannjjm 4659 39 of of IN cord-023095-4dannjjm 4659 40 the the DT cord-023095-4dannjjm 4659 41 same same JJ cord-023095-4dannjjm 4659 42 dog dog NN cord-023095-4dannjjm 4659 43 . . . cord-023095-4dannjjm 4660 1 Electronic electronic JJ cord-023095-4dannjjm 4660 2 patient patient NN cord-023095-4dannjjm 4660 3 records record NNS cord-023095-4dannjjm 4660 4 were be VBD cord-023095-4dannjjm 4660 5 reviewed review VBN cord-023095-4dannjjm 4660 6 for for IN cord-023095-4dannjjm 4660 7 CKCS CKCS NNP cord-023095-4dannjjm 4660 8 with with IN cord-023095-4dannjjm 4660 9 CM CM NNP cord-023095-4dannjjm 4660 10 which which WDT cord-023095-4dannjjm 4660 11 had have VBD cord-023095-4dannjjm 4660 12 two two CD cord-023095-4dannjjm 4660 13 separate separate JJ cord-023095-4dannjjm 4660 14 MRI MRI NNP cord-023095-4dannjjm 4660 15 scans scan NNS cord-023095-4dannjjm 4660 16 , , , cord-023095-4dannjjm 4660 17 which which WDT cord-023095-4dannjjm 4660 18 were be VBD cord-023095-4dannjjm 4660 19 a a DT cord-023095-4dannjjm 4660 20 minimum minimum NN cord-023095-4dannjjm 4660 21 of of IN cord-023095-4dannjjm 4660 22 3 3 CD cord-023095-4dannjjm 4660 23 months month NNS cord-023095-4dannjjm 4660 24 apart apart RB cord-023095-4dannjjm 4660 25 . . . cord-023095-4dannjjm 4661 1 CKCS CKCS NNP cord-023095-4dannjjm 4661 2 with with IN cord-023095-4dannjjm 4661 3 diseases disease NNS cord-023095-4dannjjm 4661 4 affecting affect VBG cord-023095-4dannjjm 4661 5 measurements measurement NNS cord-023095-4dannjjm 4661 6 were be VBD cord-023095-4dannjjm 4661 7 excluded exclude VBN cord-023095-4dannjjm 4661 8 . . . cord-023095-4dannjjm 4662 1 For for IN cord-023095-4dannjjm 4662 2 the the DT cord-023095-4dannjjm 4662 3 volumetric volumetric JJ cord-023095-4dannjjm 4662 4 measurements measurement NNS cord-023095-4dannjjm 4662 5 three three CD cord-023095-4dannjjm 4662 6 - - HYPH cord-023095-4dannjjm 4662 7 dimensional dimensional JJ cord-023095-4dannjjm 4662 8 models model NNS cord-023095-4dannjjm 4662 9 were be VBD cord-023095-4dannjjm 4662 10 created create VBN cord-023095-4dannjjm 4662 11 using use VBG cord-023095-4dannjjm 4662 12 T2-weighted t2-weighte VBN cord-023095-4dannjjm 4662 13 transverse transverse JJ cord-023095-4dannjjm 4662 14 MR MR NNP cord-023095-4dannjjm 4662 15 images image NNS cord-023095-4dannjjm 4662 16 in in IN cord-023095-4dannjjm 4662 17 the the DT cord-023095-4dannjjm 4662 18 medical medical JJ cord-023095-4dannjjm 4662 19 imaging imaging NN cord-023095-4dannjjm 4662 20 software software NN cord-023095-4dannjjm 4662 21 ( ( -LRB- cord-023095-4dannjjm 4662 22 Mimics mimic VBZ cord-023095-4dannjjm 4662 23 v12.0 v12.0 NN cord-023095-4dannjjm 4662 24 , , , cord-023095-4dannjjm 4662 25 Materialise Materialise NNP cord-023095-4dannjjm 4662 26 n.v n.v NNP cord-023095-4dannjjm 4662 27 , , , cord-023095-4dannjjm 4662 28 2008 2008 CD cord-023095-4dannjjm 4662 29 ) ) -RRB- cord-023095-4dannjjm 4662 30 . . . cord-023095-4dannjjm 4663 1 Volumes volume NNS cord-023095-4dannjjm 4663 2 of of IN cord-023095-4dannjjm 4663 3 the the DT cord-023095-4dannjjm 4663 4 caudal caudal JJ cord-023095-4dannjjm 4663 5 cranial cranial JJ cord-023095-4dannjjm 4663 6 fossa fossa NN cord-023095-4dannjjm 4663 7 parenchyma parenchyma NNS cord-023095-4dannjjm 4663 8 were be VBD cord-023095-4dannjjm 4663 9 analyzed analyze VBN cord-023095-4dannjjm 4663 10 as as IN cord-023095-4dannjjm 4663 11 percentages percentage NNS cord-023095-4dannjjm 4663 12 of of IN cord-023095-4dannjjm 4663 13 caudal caudal JJ cord-023095-4dannjjm 4663 14 cranial cranial JJ cord-023095-4dannjjm 4663 15 fossa fossa NN cord-023095-4dannjjm 4663 16 volume volume NN cord-023095-4dannjjm 4663 17 and and CC cord-023095-4dannjjm 4663 18 caudal caudal JJ cord-023095-4dannjjm 4663 19 cranial cranial JJ cord-023095-4dannjjm 4663 20 fossa fossa NN cord-023095-4dannjjm 4663 21 volume volume NN cord-023095-4dannjjm 4663 22 was be VBD cord-023095-4dannjjm 4663 23 analyzed analyze VBN cord-023095-4dannjjm 4663 24 as as IN cord-023095-4dannjjm 4663 25 a a DT cord-023095-4dannjjm 4663 26 percentage percentage NN cord-023095-4dannjjm 4663 27 of of IN cord-023095-4dannjjm 4663 28 total total JJ cord-023095-4dannjjm 4663 29 cranial cranial JJ cord-023095-4dannjjm 4663 30 cavity cavity NN cord-023095-4dannjjm 4663 31 volume volume NN cord-023095-4dannjjm 4663 32 . . . cord-023095-4dannjjm 4664 1 The the DT cord-023095-4dannjjm 4664 2 volume volume NN cord-023095-4dannjjm 4664 3 of of IN cord-023095-4dannjjm 4664 4 the the DT cord-023095-4dannjjm 4664 5 ventricular ventricular JJ cord-023095-4dannjjm 4664 6 system system NN cord-023095-4dannjjm 4664 7 was be VBD cord-023095-4dannjjm 4664 8 recorded record VBN cord-023095-4dannjjm 4664 9 as as IN cord-023095-4dannjjm 4664 10 a a DT cord-023095-4dannjjm 4664 11 percentage percentage NN cord-023095-4dannjjm 4664 12 of of IN cord-023095-4dannjjm 4664 13 total total JJ cord-023095-4dannjjm 4664 14 parenchymal parenchymal NN cord-023095-4dannjjm 4664 15 volume volume NN cord-023095-4dannjjm 4664 16 . . . cord-023095-4dannjjm 4665 1 Data datum NNS cord-023095-4dannjjm 4665 2 was be VBD cord-023095-4dannjjm 4665 3 assessed assess VBN cord-023095-4dannjjm 4665 4 for for IN cord-023095-4dannjjm 4665 5 normality normality NN cord-023095-4dannjjm 4665 6 and and CC cord-023095-4dannjjm 4665 7 the the DT cord-023095-4dannjjm 4665 8 appropriate appropriate JJ cord-023095-4dannjjm 4665 9 statistical statistical JJ cord-023095-4dannjjm 4665 10 test test NN cord-023095-4dannjjm 4665 11 was be VBD cord-023095-4dannjjm 4665 12 used use VBN cord-023095-4dannjjm 4665 13 to to TO cord-023095-4dannjjm 4665 14 compare compare VB cord-023095-4dannjjm 4665 15 means mean NNS cord-023095-4dannjjm 4665 16 / / SYM cord-023095-4dannjjm 4665 17 medians median NNS cord-023095-4dannjjm 4665 18 . . . cord-023095-4dannjjm 4666 1 Twelve twelve CD cord-023095-4dannjjm 4666 2 CKCS CKCS NNP cord-023095-4dannjjm 4666 3 were be VBD cord-023095-4dannjjm 4666 4 included include VBN cord-023095-4dannjjm 4666 5 with with IN cord-023095-4dannjjm 4666 6 a a DT cord-023095-4dannjjm 4666 7 median median JJ cord-023095-4dannjjm 4666 8 scan scan JJ cord-023095-4dannjjm 4666 9 interval interval NN cord-023095-4dannjjm 4666 10 of of IN cord-023095-4dannjjm 4666 11 9.5 9.5 CD cord-023095-4dannjjm 4666 12 months month NNS cord-023095-4dannjjm 4666 13 ( ( -LRB- cord-023095-4dannjjm 4666 14 3 3 CD cord-023095-4dannjjm 4666 15 - - SYM cord-023095-4dannjjm 4666 16 83 83 CD cord-023095-4dannjjm 4666 17 months month NNS cord-023095-4dannjjm 4666 18 ) ) -RRB- cord-023095-4dannjjm 4666 19 . . . cord-023095-4dannjjm 4667 1 The the DT cord-023095-4dannjjm 4667 2 size size NN cord-023095-4dannjjm 4667 3 of of IN cord-023095-4dannjjm 4667 4 the the DT cord-023095-4dannjjm 4667 5 foramen foramen NNP cord-023095-4dannjjm 4667 6 magnum magnum NNP cord-023095-4dannjjm 4667 7 increased increase VBD cord-023095-4dannjjm 4667 8 significantly significantly RB cord-023095-4dannjjm 4667 9 between between IN cord-023095-4dannjjm 4667 10 the the DT cord-023095-4dannjjm 4667 11 first first JJ cord-023095-4dannjjm 4667 12 and and CC cord-023095-4dannjjm 4667 13 second second JJ cord-023095-4dannjjm 4667 14 scan scan NN cord-023095-4dannjjm 4667 15 ( ( -LRB- cord-023095-4dannjjm 4667 16 1.52 1.52 CD cord-023095-4dannjjm 4667 17 AE AE NNP cord-023095-4dannjjm 4667 18 0.08 0.08 CD cord-023095-4dannjjm 4667 19 cm cm NNS cord-023095-4dannjjm 4667 20 vs. vs. NN cord-023095-4dannjjm 4667 21 1.59 1.59 CD cord-023095-4dannjjm 4667 22 AE AE NNP cord-023095-4dannjjm 4667 23 0.09 0.09 CD cord-023095-4dannjjm 4667 24 cm cm NNS cord-023095-4dannjjm 4667 25 ; ; : cord-023095-4dannjjm 4667 26 p p NN cord-023095-4dannjjm 4667 27 5 5 CD cord-023095-4dannjjm 4667 28 0.03 0.03 CD cord-023095-4dannjjm 4667 29 ) ) -RRB- cord-023095-4dannjjm 4667 30 , , , cord-023095-4dannjjm 4667 31 as as IN cord-023095-4dannjjm 4667 32 did do VBD cord-023095-4dannjjm 4667 33 the the DT cord-023095-4dannjjm 4667 34 length length NN cord-023095-4dannjjm 4667 35 of of IN cord-023095-4dannjjm 4667 36 cerebellar cerebellar JJ cord-023095-4dannjjm 4667 37 herniation herniation NN cord-023095-4dannjjm 4667 38 ( ( -LRB- cord-023095-4dannjjm 4667 39 0.17 0.17 CD cord-023095-4dannjjm 4667 40 AE AE NNP cord-023095-4dannjjm 4667 41 0.05 0.05 CD cord-023095-4dannjjm 4667 42 cm cm NNS cord-023095-4dannjjm 4667 43 vs. vs. NN cord-023095-4dannjjm 4667 44 0.22 0.22 CD cord-023095-4dannjjm 4667 45 AE AE NNP cord-023095-4dannjjm 4667 46 0.09 0.09 CD cord-023095-4dannjjm 4667 47 cm cm NNS cord-023095-4dannjjm 4667 48 ; ; : cord-023095-4dannjjm 4667 49 p p NN cord-023095-4dannjjm 4667 50 5 5 CD cord-023095-4dannjjm 4667 51 0.02 0.02 CD cord-023095-4dannjjm 4667 52 ) ) -RRB- cord-023095-4dannjjm 4667 53 and and CC cord-023095-4dannjjm 4667 54 the the DT cord-023095-4dannjjm 4667 55 caudal caudal JJ cord-023095-4dannjjm 4667 56 cranial cranial JJ cord-023095-4dannjjm 4667 57 fossa fossa NN cord-023095-4dannjjm 4667 58 percentage percentage NN cord-023095-4dannjjm 4667 59 ( ( -LRB- cord-023095-4dannjjm 4667 60 13.44 13.44 CD cord-023095-4dannjjm 4667 61 % % NN cord-023095-4dannjjm 4667 62 [ [ -LRB- cord-023095-4dannjjm 4667 63 9.9 9.9 CD cord-023095-4dannjjm 4667 64 - - HYPH cord-023095-4dannjjm 4667 65 15.28 15.28 CD cord-023095-4dannjjm 4667 66 % % NN cord-023095-4dannjjm 4667 67 ] ] -RRB- cord-023095-4dannjjm 4667 68 vs. vs. IN cord-023095-4dannjjm 4667 69 13.96 13.96 CD cord-023095-4dannjjm 4667 70 % % NN cord-023095-4dannjjm 4667 71 [ [ -LRB- cord-023095-4dannjjm 4667 72 9.9 9.9 CD cord-023095-4dannjjm 4667 73 - - HYPH cord-023095-4dannjjm 4667 74 15.48 15.48 CD cord-023095-4dannjjm 4667 75 % % NN cord-023095-4dannjjm 4667 76 ] ] -RRB- cord-023095-4dannjjm 4667 77 ; ; : cord-023095-4dannjjm 4667 78 p p NN cord-023095-4dannjjm 4667 79 5 5 CD cord-023095-4dannjjm 4667 80 0.02 0.02 CD cord-023095-4dannjjm 4667 81 ) ) -RRB- cord-023095-4dannjjm 4667 82 . . . cord-023095-4dannjjm 4668 1 There there EX cord-023095-4dannjjm 4668 2 was be VBD cord-023095-4dannjjm 4668 3 no no DT cord-023095-4dannjjm 4668 4 significant significant JJ cord-023095-4dannjjm 4668 5 difference difference NN cord-023095-4dannjjm 4668 6 noted note VBN cord-023095-4dannjjm 4668 7 between between IN cord-023095-4dannjjm 4668 8 the the DT cord-023095-4dannjjm 4668 9 two two CD cord-023095-4dannjjm 4668 10 time time NN cord-023095-4dannjjm 4668 11 points point NNS cord-023095-4dannjjm 4668 12 in in IN cord-023095-4dannjjm 4668 13 any any DT cord-023095-4dannjjm 4668 14 of of IN cord-023095-4dannjjm 4668 15 the the DT cord-023095-4dannjjm 4668 16 other other JJ cord-023095-4dannjjm 4668 17 volumetric volumetric JJ cord-023095-4dannjjm 4668 18 measurements measurement NNS cord-023095-4dannjjm 4669 1 ( ( -LRB- cord-023095-4dannjjm 4669 2 This this DT cord-023095-4dannjjm 4669 3 work work NN cord-023095-4dannjjm 4669 4 could could MD cord-023095-4dannjjm 4669 5 suggest suggest VB cord-023095-4dannjjm 4669 6 that that IN cord-023095-4dannjjm 4669 7 overcrowding overcrowding NN cord-023095-4dannjjm 4669 8 of of IN cord-023095-4dannjjm 4669 9 the the DT cord-023095-4dannjjm 4669 10 caudal caudal JJ cord-023095-4dannjjm 4669 11 cranial cranial JJ cord-023095-4dannjjm 4669 12 fossa fossa NN cord-023095-4dannjjm 4669 13 in in IN cord-023095-4dannjjm 4669 14 conjunction conjunction NN cord-023095-4dannjjm 4669 15 with with IN cord-023095-4dannjjm 4669 16 the the DT cord-023095-4dannjjm 4669 17 movements movement NNS cord-023095-4dannjjm 4669 18 of of IN cord-023095-4dannjjm 4669 19 cerebrospinal cerebrospinal JJ cord-023095-4dannjjm 4669 20 fluid fluid NN cord-023095-4dannjjm 4669 21 and and CC cord-023095-4dannjjm 4669 22 cerebellar cerebellar JJ cord-023095-4dannjjm 4669 23 tissue tissue NN cord-023095-4dannjjm 4669 24 secondary secondary JJ cord-023095-4dannjjm 4669 25 to to TO cord-023095-4dannjjm 4669 26 pulse pulse NN cord-023095-4dannjjm 4669 27 pressures pressure NNS cord-023095-4dannjjm 4669 28 created create VBN cord-023095-4dannjjm 4669 29 during during IN cord-023095-4dannjjm 4669 30 the the DT cord-023095-4dannjjm 4669 31 cardiac cardiac JJ cord-023095-4dannjjm 4669 32 cycle cycle NN cord-023095-4dannjjm 4669 33 causes cause VBZ cord-023095-4dannjjm 4669 34 pressures pressure NNS cord-023095-4dannjjm 4669 35 on on IN cord-023095-4dannjjm 4669 36 the the DT cord-023095-4dannjjm 4669 37 occipital occipital JJ cord-023095-4dannjjm 4669 38 bone bone NN cord-023095-4dannjjm 4669 39 . . . cord-023095-4dannjjm 4670 1 This this DT cord-023095-4dannjjm 4670 2 leads lead VBZ cord-023095-4dannjjm 4670 3 to to IN cord-023095-4dannjjm 4670 4 a a DT cord-023095-4dannjjm 4670 5 resorption resorption NN cord-023095-4dannjjm 4670 6 of of IN cord-023095-4dannjjm 4670 7 the the DT cord-023095-4dannjjm 4670 8 bone bone NN cord-023095-4dannjjm 4670 9 and and CC cord-023095-4dannjjm 4670 10 therefore therefore RB cord-023095-4dannjjm 4670 11 an an DT cord-023095-4dannjjm 4670 12 increase increase NN cord-023095-4dannjjm 4670 13 in in IN cord-023095-4dannjjm 4670 14 caudal caudal JJ cord-023095-4dannjjm 4670 15 cranial cranial JJ cord-023095-4dannjjm 4670 16 fossa fossa NN cord-023095-4dannjjm 4670 17 and and CC cord-023095-4dannjjm 4670 18 foramen foramen NNP cord-023095-4dannjjm 4670 19 magnum magnum NNP cord-023095-4dannjjm 4670 20 size size NN cord-023095-4dannjjm 4670 21 allowing allow VBG cord-023095-4dannjjm 4670 22 cerebellar cerebellar JJ cord-023095-4dannjjm 4670 23 herniation herniation NN cord-023095-4dannjjm 4670 24 length length NN cord-023095-4dannjjm 4670 25 to to TO cord-023095-4dannjjm 4670 26 increase increase VB cord-023095-4dannjjm 4670 27 . . . cord-023095-4dannjjm 4671 1 The the DT cord-023095-4dannjjm 4671 2 cord cord NN cord-023095-4dannjjm 4671 3 dorsum dorsum NN cord-023095-4dannjjm 4671 4 potential potential NN cord-023095-4dannjjm 4671 5 ( ( -LRB- cord-023095-4dannjjm 4671 6 CDP CDP NNP cord-023095-4dannjjm 4671 7 ) ) -RRB- cord-023095-4dannjjm 4671 8 is be VBZ cord-023095-4dannjjm 4671 9 a a DT cord-023095-4dannjjm 4671 10 stationary stationary JJ cord-023095-4dannjjm 4671 11 potential potential NN cord-023095-4dannjjm 4671 12 arising arise VBG cord-023095-4dannjjm 4671 13 in in IN cord-023095-4dannjjm 4671 14 dorsal dorsal JJ cord-023095-4dannjjm 4671 15 horn horn NN cord-023095-4dannjjm 4671 16 interneurons interneuron NNS cord-023095-4dannjjm 4671 17 after after IN cord-023095-4dannjjm 4671 18 stimulation stimulation NN cord-023095-4dannjjm 4671 19 of of IN cord-023095-4dannjjm 4671 20 sensory sensory JJ cord-023095-4dannjjm 4671 21 nerves nerve NNS cord-023095-4dannjjm 4671 22 . . . cord-023095-4dannjjm 4672 1 CDPs cdp NNS cord-023095-4dannjjm 4672 2 have have VBP cord-023095-4dannjjm 4672 3 been be VBN cord-023095-4dannjjm 4672 4 recorded record VBN cord-023095-4dannjjm 4672 5 in in IN cord-023095-4dannjjm 4672 6 normal normal JJ cord-023095-4dannjjm 4672 7 anesthetized anesthetize VBN cord-023095-4dannjjm 4672 8 dogs dog NNS cord-023095-4dannjjm 4672 9 previously previously RB cord-023095-4dannjjm 4672 10 , , , cord-023095-4dannjjm 4672 11 and and CC cord-023095-4dannjjm 4672 12 normal normal JJ cord-023095-4dannjjm 4672 13 latency latency NN cord-023095-4dannjjm 4672 14 values value NNS cord-023095-4dannjjm 4672 15 have have VBP cord-023095-4dannjjm 4672 16 been be VBN cord-023095-4dannjjm 4672 17 determined determine VBN cord-023095-4dannjjm 4672 18 for for IN cord-023095-4dannjjm 4672 19 tibial tibial JJ cord-023095-4dannjjm 4672 20 and and CC cord-023095-4dannjjm 4672 21 radial radial JJ cord-023095-4dannjjm 4672 22 nerves nerve NNS cord-023095-4dannjjm 4672 23 . . . cord-023095-4dannjjm 4673 1 This this DT cord-023095-4dannjjm 4673 2 study study NN cord-023095-4dannjjm 4673 3 was be VBD cord-023095-4dannjjm 4673 4 undertaken undertake VBN cord-023095-4dannjjm 4673 5 to to TO cord-023095-4dannjjm 4673 6 determine determine VB cord-023095-4dannjjm 4673 7 whether whether IN cord-023095-4dannjjm 4673 8 CDPs cdp NNS cord-023095-4dannjjm 4673 9 could could MD cord-023095-4dannjjm 4673 10 be be VB cord-023095-4dannjjm 4673 11 reliably reliably RB cord-023095-4dannjjm 4673 12 recorded record VBN cord-023095-4dannjjm 4673 13 from from IN cord-023095-4dannjjm 4673 14 the the DT cord-023095-4dannjjm 4673 15 caudal caudal JJ cord-023095-4dannjjm 4673 16 nerves nerve NNS cord-023095-4dannjjm 4673 17 in in IN cord-023095-4dannjjm 4673 18 normal normal JJ cord-023095-4dannjjm 4673 19 dogs dog NNS cord-023095-4dannjjm 4673 20 , , , cord-023095-4dannjjm 4673 21 thus thus RB cord-023095-4dannjjm 4673 22 allowing allow VBG cord-023095-4dannjjm 4673 23 electrophysiological electrophysiological JJ cord-023095-4dannjjm 4673 24 assessment assessment NN cord-023095-4dannjjm 4673 25 of of IN cord-023095-4dannjjm 4673 26 the the DT cord-023095-4dannjjm 4673 27 cauda cauda FW cord-023095-4dannjjm 4673 28 equina equina NN cord-023095-4dannjjm 4673 29 , , , cord-023095-4dannjjm 4673 30 and and CC cord-023095-4dannjjm 4673 31 whether whether IN cord-023095-4dannjjm 4673 32 neuromuscular neuromuscular JJ cord-023095-4dannjjm 4673 33 blockade blockade NN cord-023095-4dannjjm 4673 34 improved improve VBN cord-023095-4dannjjm 4673 35 recording record VBG cord-023095-4dannjjm 4673 36 quality quality NN cord-023095-4dannjjm 4673 37 . . . cord-023095-4dannjjm 4674 1 Ten ten CD cord-023095-4dannjjm 4674 2 adult adult NN cord-023095-4dannjjm 4674 3 dogs dog NNS cord-023095-4dannjjm 4674 4 weighing weigh VBG cord-023095-4dannjjm 4674 5 from from IN cord-023095-4dannjjm 4674 6 23.2 23.2 CD cord-023095-4dannjjm 4674 7 to to IN cord-023095-4dannjjm 4674 8 32.0 32.0 CD cord-023095-4dannjjm 4674 9 kg kg NNS cord-023095-4dannjjm 4674 10 were be VBD cord-023095-4dannjjm 4674 11 anesthetized anesthetize VBN cord-023095-4dannjjm 4674 12 and and CC cord-023095-4dannjjm 4674 13 cord cord NN cord-023095-4dannjjm 4674 14 dorsum dorsum NN cord-023095-4dannjjm 4674 15 recordings recording NNS cord-023095-4dannjjm 4674 16 were be VBD cord-023095-4dannjjm 4674 17 compared compare VBN cord-023095-4dannjjm 4674 18 before before IN cord-023095-4dannjjm 4674 19 and and CC cord-023095-4dannjjm 4674 20 after after IN cord-023095-4dannjjm 4674 21 administration administration NN cord-023095-4dannjjm 4674 22 of of IN cord-023095-4dannjjm 4674 23 atracurium atracurium NNP cord-023095-4dannjjm 4674 24 . . . cord-023095-4dannjjm 4675 1 Recording record VBG cord-023095-4dannjjm 4675 2 needles needle NNS cord-023095-4dannjjm 4675 3 were be VBD cord-023095-4dannjjm 4675 4 placed place VBN cord-023095-4dannjjm 4675 5 onto onto IN cord-023095-4dannjjm 4675 6 the the DT cord-023095-4dannjjm 4675 7 dorsal dorsal JJ cord-023095-4dannjjm 4675 8 lamina lamina NN cord-023095-4dannjjm 4675 9 at at IN cord-023095-4dannjjm 4675 10 intervertebral intervertebral JJ cord-023095-4dannjjm 4675 11 sites site NNS cord-023095-4dannjjm 4675 12 from from IN cord-023095-4dannjjm 4675 13 L7 L7 NNP cord-023095-4dannjjm 4675 14 / / SYM cord-023095-4dannjjm 4675 15 S1 S1 NNP cord-023095-4dannjjm 4675 16 to to IN cord-023095-4dannjjm 4675 17 L2/3 L2/3 NNP cord-023095-4dannjjm 4675 18 . . . cord-023095-4dannjjm 4676 1 Stimulations Stimulations NNPS cord-023095-4dannjjm 4676 2 were be VBD cord-023095-4dannjjm 4676 3 made make VBN cord-023095-4dannjjm 4676 4 on on IN cord-023095-4dannjjm 4676 5 the the DT cord-023095-4dannjjm 4676 6 lateral lateral JJ cord-023095-4dannjjm 4676 7 aspect aspect NN cord-023095-4dannjjm 4676 8 of of IN cord-023095-4dannjjm 4676 9 the the DT cord-023095-4dannjjm 4676 10 caudal caudal JJ cord-023095-4dannjjm 4676 11 vertebrae vertebrae NN cord-023095-4dannjjm 4676 12 approximately approximately RB cord-023095-4dannjjm 4676 13 5 5 CD cord-023095-4dannjjm 4676 14 - - SYM cord-023095-4dannjjm 4676 15 8 8 CD cord-023095-4dannjjm 4676 16 cm cm NNS cord-023095-4dannjjm 4676 17 from from IN cord-023095-4dannjjm 4676 18 the the DT cord-023095-4dannjjm 4676 19 tail tail NN cord-023095-4dannjjm 4676 20 base base NN cord-023095-4dannjjm 4676 21 . . . cord-023095-4dannjjm 4677 1 Recordings recording NNS cord-023095-4dannjjm 4677 2 from from IN cord-023095-4dannjjm 4677 3 500 500 CD cord-023095-4dannjjm 4677 4 stimulations stimulation NNS cord-023095-4dannjjm 4677 5 were be VBD cord-023095-4dannjjm 4677 6 averaged average VBN cord-023095-4dannjjm 4677 7 . . . cord-023095-4dannjjm 4678 1 CDPs CDPs NNP cord-023095-4dannjjm 4678 2 were be VBD cord-023095-4dannjjm 4678 3 recorded record VBN cord-023095-4dannjjm 4678 4 successfully successfully RB cord-023095-4dannjjm 4678 5 in in IN cord-023095-4dannjjm 4678 6 all all DT cord-023095-4dannjjm 4678 7 dogs dog NNS cord-023095-4dannjjm 4678 8 . . . cord-023095-4dannjjm 4679 1 Onset onset NN cord-023095-4dannjjm 4679 2 latency latency NN cord-023095-4dannjjm 4679 3 varied varied JJ cord-023095-4dannjjm 4679 4 from from IN cord-023095-4dannjjm 4679 5 2.2 2.2 CD cord-023095-4dannjjm 4679 6 to to IN cord-023095-4dannjjm 4679 7 4.7 4.7 CD cord-023095-4dannjjm 4679 8 ms m NNS cord-023095-4dannjjm 4679 9 . . . cord-023095-4dannjjm 4680 1 The the DT cord-023095-4dannjjm 4680 2 CDP CDP NNP cord-023095-4dannjjm 4680 3 was be VBD cord-023095-4dannjjm 4680 4 largest large JJS cord-023095-4dannjjm 4680 5 when when WRB cord-023095-4dannjjm 4680 6 recorded record VBN cord-023095-4dannjjm 4680 7 closest close JJS cord-023095-4dannjjm 4680 8 to to IN cord-023095-4dannjjm 4680 9 the the DT cord-023095-4dannjjm 4680 10 site site NN cord-023095-4dannjjm 4680 11 of of IN cord-023095-4dannjjm 4680 12 entry entry NN cord-023095-4dannjjm 4680 13 of of IN cord-023095-4dannjjm 4680 14 the the DT cord-023095-4dannjjm 4680 15 stimulated stimulated JJ cord-023095-4dannjjm 4680 16 nerve nerve NN cord-023095-4dannjjm 4680 17 into into IN cord-023095-4dannjjm 4680 18 the the DT cord-023095-4dannjjm 4680 19 cord cord NN cord-023095-4dannjjm 4680 20 , , , cord-023095-4dannjjm 4680 21 as as IN cord-023095-4dannjjm 4680 22 determined determine VBN cord-023095-4dannjjm 4680 23 by by IN cord-023095-4dannjjm 4680 24 post post JJ cord-023095-4dannjjm 4680 25 - - JJ cord-023095-4dannjjm 4680 26 mortem mortem JJ cord-023095-4dannjjm 4680 27 examination examination NN cord-023095-4dannjjm 4680 28 immediately immediately RB cord-023095-4dannjjm 4680 29 after after IN cord-023095-4dannjjm 4680 30 testing test VBG cord-023095-4dannjjm 4680 31 in in IN cord-023095-4dannjjm 4680 32 6 6 CD cord-023095-4dannjjm 4680 33 dogs dog NNS cord-023095-4dannjjm 4680 34 . . . cord-023095-4dannjjm 4681 1 Administration Administration NNP cord-023095-4dannjjm 4681 2 of of IN cord-023095-4dannjjm 4681 3 atracurium atracurium NNP cord-023095-4dannjjm 4681 4 did do VBD cord-023095-4dannjjm 4681 5 decrease decrease VB cord-023095-4dannjjm 4681 6 muscle muscle NN cord-023095-4dannjjm 4681 7 artifact artifact NN cord-023095-4dannjjm 4681 8 , , , cord-023095-4dannjjm 4681 9 and and CC cord-023095-4dannjjm 4681 10 in in IN cord-023095-4dannjjm 4681 11 some some DT cord-023095-4dannjjm 4681 12 cases case NNS cord-023095-4dannjjm 4681 13 helped help VBD cord-023095-4dannjjm 4681 14 isolate isolate VB cord-023095-4dannjjm 4681 15 the the DT cord-023095-4dannjjm 4681 16 origin origin NN cord-023095-4dannjjm 4681 17 of of IN cord-023095-4dannjjm 4681 18 the the DT cord-023095-4dannjjm 4681 19 CDP CDP NNP cord-023095-4dannjjm 4681 20 . . . cord-023095-4dannjjm 4682 1 These these DT cord-023095-4dannjjm 4682 2 data datum NNS cord-023095-4dannjjm 4682 3 show show VBP cord-023095-4dannjjm 4682 4 that that IN cord-023095-4dannjjm 4682 5 CDPs cdp NNS cord-023095-4dannjjm 4682 6 can can MD cord-023095-4dannjjm 4682 7 be be VB cord-023095-4dannjjm 4682 8 readily readily RB cord-023095-4dannjjm 4682 9 assessed assess VBN cord-023095-4dannjjm 4682 10 from from IN cord-023095-4dannjjm 4682 11 the the DT cord-023095-4dannjjm 4682 12 caudal caudal JJ cord-023095-4dannjjm 4682 13 nerves nerve NNS cord-023095-4dannjjm 4682 14 of of IN cord-023095-4dannjjm 4682 15 anesthetized anesthetize VBN cord-023095-4dannjjm 4682 16 dogs dog NNS cord-023095-4dannjjm 4682 17 , , , cord-023095-4dannjjm 4682 18 with with IN cord-023095-4dannjjm 4682 19 or or CC cord-023095-4dannjjm 4682 20 without without IN cord-023095-4dannjjm 4682 21 atracurium atracurium NN cord-023095-4dannjjm 4682 22 . . . cord-023095-4dannjjm 4683 1 Cord cord NN cord-023095-4dannjjm 4683 2 dorsum dorsum NN cord-023095-4dannjjm 4683 3 potentials potential NNS cord-023095-4dannjjm 4683 4 from from IN cord-023095-4dannjjm 4683 5 caudal caudal JJ cord-023095-4dannjjm 4683 6 nerves nerve NNS cord-023095-4dannjjm 4683 7 may may MD cord-023095-4dannjjm 4683 8 add add VB cord-023095-4dannjjm 4683 9 important important JJ cord-023095-4dannjjm 4683 10 information information NN cord-023095-4dannjjm 4683 11 about about IN cord-023095-4dannjjm 4683 12 the the DT cord-023095-4dannjjm 4683 13 integrity integrity NN cord-023095-4dannjjm 4683 14 of of IN cord-023095-4dannjjm 4683 15 the the DT cord-023095-4dannjjm 4683 16 cauda cauda FW cord-023095-4dannjjm 4683 17 equina equina NN cord-023095-4dannjjm 4683 18 in in IN cord-023095-4dannjjm 4683 19 dogs dog NNS cord-023095-4dannjjm 4683 20 with with IN cord-023095-4dannjjm 4683 21 suspected suspect VBN cord-023095-4dannjjm 4683 22 degenerative degenerative JJ cord-023095-4dannjjm 4683 23 lumbosacral lumbosacral JJ cord-023095-4dannjjm 4683 24 stenosis stenosis NN cord-023095-4dannjjm 4683 25 . . . cord-023095-4dannjjm 4684 1 Canine canine JJ cord-023095-4dannjjm 4684 2 intracranial intracranial JJ cord-023095-4dannjjm 4684 3 glial glial JJ cord-023095-4dannjjm 4684 4 tumors tumor NNS cord-023095-4dannjjm 4684 5 and and CC cord-023095-4dannjjm 4684 6 many many JJ cord-023095-4dannjjm 4684 7 human human JJ cord-023095-4dannjjm 4684 8 brain brain NN cord-023095-4dannjjm 4684 9 tumors tumor NNS cord-023095-4dannjjm 4684 10 express express VBP cord-023095-4dannjjm 4684 11 heat heat NN cord-023095-4dannjjm 4684 12 shock shock NN cord-023095-4dannjjm 4684 13 proteins protein NNS cord-023095-4dannjjm 4684 14 ( ( -LRB- cord-023095-4dannjjm 4684 15 HSPs HSPs NNP cord-023095-4dannjjm 4684 16 ) ) -RRB- cord-023095-4dannjjm 4684 17 associated associate VBN cord-023095-4dannjjm 4684 18 with with IN cord-023095-4dannjjm 4684 19 their -PRON- PRP$ cord-023095-4dannjjm 4684 20 degree degree NN cord-023095-4dannjjm 4684 21 of of IN cord-023095-4dannjjm 4684 22 malignancy malignancy NN cord-023095-4dannjjm 4684 23 . . . cord-023095-4dannjjm 4685 1 The the DT cord-023095-4dannjjm 4685 2 up up JJ cord-023095-4dannjjm 4685 3 - - HYPH cord-023095-4dannjjm 4685 4 regulation regulation NN cord-023095-4dannjjm 4685 5 of of IN cord-023095-4dannjjm 4685 6 HSPs hsp NNS cord-023095-4dannjjm 4685 7 during during IN cord-023095-4dannjjm 4685 8 tumor tumor NN cord-023095-4dannjjm 4685 9 cell cell NN cord-023095-4dannjjm 4685 10 growth growth NN cord-023095-4dannjjm 4685 11 helps help VBZ cord-023095-4dannjjm 4685 12 keep keep VB cord-023095-4dannjjm 4685 13 tumor tumor NN cord-023095-4dannjjm 4685 14 proteins protein NNS cord-023095-4dannjjm 4685 15 stable stable JJ cord-023095-4dannjjm 4685 16 and and CC cord-023095-4dannjjm 4685 17 therefore therefore RB cord-023095-4dannjjm 4685 18 makes make VBZ cord-023095-4dannjjm 4685 19 them -PRON- PRP cord-023095-4dannjjm 4685 20 a a DT cord-023095-4dannjjm 4685 21 reasonable reasonable JJ cord-023095-4dannjjm 4685 22 target target NN cord-023095-4dannjjm 4685 23 for for IN cord-023095-4dannjjm 4685 24 therapy therapy NN cord-023095-4dannjjm 4685 25 . . . cord-023095-4dannjjm 4686 1 Ki67 Ki67 NNP cord-023095-4dannjjm 4686 2 expression expression NN cord-023095-4dannjjm 4686 3 and and CC cord-023095-4dannjjm 4686 4 EC EC NNP cord-023095-4dannjjm 4686 5 have have VBP cord-023095-4dannjjm 4686 6 been be VBN cord-023095-4dannjjm 4686 7 strong strong JJ cord-023095-4dannjjm 4686 8 indicators indicator NNS cord-023095-4dannjjm 4686 9 of of IN cord-023095-4dannjjm 4686 10 cell cell NN cord-023095-4dannjjm 4686 11 proliferation proliferation NN cord-023095-4dannjjm 4686 12 and and CC cord-023095-4dannjjm 4686 13 dedifferentiation dedifferentiation NN cord-023095-4dannjjm 4686 14 , , , cord-023095-4dannjjm 4686 15 respectively respectively RB cord-023095-4dannjjm 4686 16 . . . cord-023095-4dannjjm 4687 1 The the DT cord-023095-4dannjjm 4687 2 aims aim NNS cord-023095-4dannjjm 4687 3 of of IN cord-023095-4dannjjm 4687 4 this this DT cord-023095-4dannjjm 4687 5 study study NN cord-023095-4dannjjm 4687 6 were be VBD cord-023095-4dannjjm 4687 7 to to TO cord-023095-4dannjjm 4687 8 determine determine VB cord-023095-4dannjjm 4687 9 ( ( -LRB- cord-023095-4dannjjm 4687 10 i i NN cord-023095-4dannjjm 4687 11 ) ) -RRB- cord-023095-4dannjjm 4687 12 if if IN cord-023095-4dannjjm 4687 13 canine canine JJ cord-023095-4dannjjm 4687 14 meningiomas meningiomas NN cord-023095-4dannjjm 4687 15 express expres VBD cord-023095-4dannjjm 4687 16 HSP HSP NNP cord-023095-4dannjjm 4687 17 27 27 CD cord-023095-4dannjjm 4687 18 and/or and/or CC cord-023095-4dannjjm 4687 19 HSP HSP NNP cord-023095-4dannjjm 4687 20 72 72 CD cord-023095-4dannjjm 4687 21 ; ; : cord-023095-4dannjjm 4687 22 ( ( -LRB- cord-023095-4dannjjm 4687 23 ii ii NN cord-023095-4dannjjm 4687 24 ) ) -RRB- cord-023095-4dannjjm 4688 1 whether whether IN cord-023095-4dannjjm 4688 2 the the DT cord-023095-4dannjjm 4688 3 expression expression NN cord-023095-4dannjjm 4688 4 of of IN cord-023095-4dannjjm 4688 5 the the DT cord-023095-4dannjjm 4688 6 HSPs hsp NNS cord-023095-4dannjjm 4688 7 was be VBD cord-023095-4dannjjm 4688 8 associated associate VBN cord-023095-4dannjjm 4688 9 with with IN cord-023095-4dannjjm 4688 10 Ki67 Ki67 NNP cord-023095-4dannjjm 4689 1 and/or and/or CC cord-023095-4dannjjm 4689 2 E e NN cord-023095-4dannjjm 4689 3 - - NN cord-023095-4dannjjm 4689 4 cadherin cadherin NN cord-023095-4dannjjm 4689 5 ( ( -LRB- cord-023095-4dannjjm 4689 6 EC EC NNP cord-023095-4dannjjm 4689 7 ) ) -RRB- cord-023095-4dannjjm 4689 8 expression expression NN cord-023095-4dannjjm 4689 9 ; ; : cord-023095-4dannjjm 4689 10 and and CC cord-023095-4dannjjm 4689 11 ( ( -LRB- cord-023095-4dannjjm 4689 12 iii iii NN cord-023095-4dannjjm 4689 13 ) ) -RRB- cord-023095-4dannjjm 4690 1 whether whether IN cord-023095-4dannjjm 4690 2 peritumoral peritumoral JJ cord-023095-4dannjjm 4690 3 edema edema NN cord-023095-4dannjjm 4690 4 was be VBD cord-023095-4dannjjm 4690 5 associated associate VBN cord-023095-4dannjjm 4690 6 with with IN cord-023095-4dannjjm 4690 7 HSP HSP NNP cord-023095-4dannjjm 4690 8 , , , cord-023095-4dannjjm 4690 9 Ki67 Ki67 NNP cord-023095-4dannjjm 4690 10 and/or and/or CC cord-023095-4dannjjm 4690 11 EC EC NNP cord-023095-4dannjjm 4690 12 expression expression NN cord-023095-4dannjjm 4690 13 . . . cord-023095-4dannjjm 4691 1 Forty forty CD cord-023095-4dannjjm 4691 2 - - HYPH cord-023095-4dannjjm 4691 3 one one CD cord-023095-4dannjjm 4692 1 formalin formalin NN cord-023095-4dannjjm 4692 2 - - HYPH cord-023095-4dannjjm 4692 3 fixed fix VBN cord-023095-4dannjjm 4692 4 , , , cord-023095-4dannjjm 4692 5 paraffin paraffin NN cord-023095-4dannjjm 4692 6 - - HYPH cord-023095-4dannjjm 4692 7 embedded embed VBN cord-023095-4dannjjm 4692 8 canine canine JJ cord-023095-4dannjjm 4692 9 intracranial intracranial JJ cord-023095-4dannjjm 4692 10 meningiomas meningiomas NN cord-023095-4dannjjm 4692 11 underwent undergo VBD cord-023095-4dannjjm 4692 12 immunohistochemical immunohistochemical JJ cord-023095-4dannjjm 4692 13 staining stain VBG cord-023095-4dannjjm 4692 14 using use VBG cord-023095-4dannjjm 4692 15 anti anti JJ cord-023095-4dannjjm 4692 16 - - JJ cord-023095-4dannjjm 4692 17 HSP HSP NNP cord-023095-4dannjjm 4692 18 27 27 CD cord-023095-4dannjjm 4692 19 , , , cord-023095-4dannjjm 4692 20 or or CC cord-023095-4dannjjm 4692 21 72 72 CD cord-023095-4dannjjm 4692 22 antibodies antibody NNS cord-023095-4dannjjm 4692 23 . . . cord-023095-4dannjjm 4693 1 These these DT cord-023095-4dannjjm 4693 2 tumor tumor NN cord-023095-4dannjjm 4693 3 samples sample NNS cord-023095-4dannjjm 4693 4 were be VBD cord-023095-4dannjjm 4693 5 also also RB cord-023095-4dannjjm 4693 6 immunohistochemically immunohistochemically RB cord-023095-4dannjjm 4693 7 stained stain VBN cord-023095-4dannjjm 4693 8 for for IN cord-023095-4dannjjm 4693 9 Ki67 Ki67 NNP cord-023095-4dannjjm 4693 10 and and CC cord-023095-4dannjjm 4693 11 EC EC NNP cord-023095-4dannjjm 4693 12 expression expression NN cord-023095-4dannjjm 4693 13 . . . cord-023095-4dannjjm 4694 1 Canine canine JJ cord-023095-4dannjjm 4694 2 mammary mammary JJ cord-023095-4dannjjm 4694 3 carcinoma carcinoma NN cord-023095-4dannjjm 4694 4 and and CC cord-023095-4dannjjm 4694 5 squamous squamous JJ cord-023095-4dannjjm 4694 6 cell cell NN cord-023095-4dannjjm 4694 7 carcinoma carcinoma NN cord-023095-4dannjjm 4694 8 tissues tissue NNS cord-023095-4dannjjm 4694 9 served serve VBD cord-023095-4dannjjm 4694 10 as as IN cord-023095-4dannjjm 4694 11 the the DT cord-023095-4dannjjm 4694 12 control control NN cord-023095-4dannjjm 4694 13 samples sample NNS cord-023095-4dannjjm 4694 14 , , , cord-023095-4dannjjm 4694 15 as as IN cord-023095-4dannjjm 4694 16 both both DT cord-023095-4dannjjm 4694 17 have have VBP cord-023095-4dannjjm 4694 18 previously previously RB cord-023095-4dannjjm 4694 19 been be VBN cord-023095-4dannjjm 4694 20 shown show VBN cord-023095-4dannjjm 4694 21 to to TO cord-023095-4dannjjm 4694 22 express express VB cord-023095-4dannjjm 4694 23 HSPs hsp NNS cord-023095-4dannjjm 4694 24 . . . cord-023095-4dannjjm 4695 1 Skin skin NN cord-023095-4dannjjm 4695 2 was be VBD cord-023095-4dannjjm 4695 3 used use VBN cord-023095-4dannjjm 4695 4 as as IN cord-023095-4dannjjm 4695 5 control control NN cord-023095-4dannjjm 4695 6 for for IN cord-023095-4dannjjm 4695 7 Ki67 Ki67 NNP cord-023095-4dannjjm 4695 8 and and CC cord-023095-4dannjjm 4695 9 EC EC NNP cord-023095-4dannjjm 4695 10 . . . cord-023095-4dannjjm 4696 1 Four four CD cord-023095-4dannjjm 4696 2 non non JJ cord-023095-4dannjjm 4696 3 - - JJ cord-023095-4dannjjm 4696 4 overlapping overlapping JJ cord-023095-4dannjjm 4696 5 high high JJ cord-023095-4dannjjm 4696 6 power power NN cord-023095-4dannjjm 4696 7 fields field NNS cord-023095-4dannjjm 4696 8 of of IN cord-023095-4dannjjm 4696 9 each each DT cord-023095-4dannjjm 4696 10 stained stain VBN cord-023095-4dannjjm 4696 11 sample sample NN cord-023095-4dannjjm 4696 12 were be VBD cord-023095-4dannjjm 4696 13 selected select VBN cord-023095-4dannjjm 4696 14 and and CC cord-023095-4dannjjm 4696 15 cell cell NN cord-023095-4dannjjm 4696 16 staining staining NN cord-023095-4dannjjm 4696 17 was be VBD cord-023095-4dannjjm 4696 18 analyzed analyze VBN cord-023095-4dannjjm 4696 19 using use VBG cord-023095-4dannjjm 4696 20 a a DT cord-023095-4dannjjm 4696 21 semi semi JJ cord-023095-4dannjjm 4696 22 - - JJ cord-023095-4dannjjm 4696 23 quantitative quantitative JJ cord-023095-4dannjjm 4696 24 method method NN cord-023095-4dannjjm 4696 25 for for IN cord-023095-4dannjjm 4696 26 HSPs hsp NNS cord-023095-4dannjjm 4696 27 and and CC cord-023095-4dannjjm 4696 28 Ki67 Ki67 NNP cord-023095-4dannjjm 4696 29 ; ; : cord-023095-4dannjjm 4696 30 a a DT cord-023095-4dannjjm 4696 31 qualitative qualitative JJ cord-023095-4dannjjm 4696 32 assessment assessment NN cord-023095-4dannjjm 4696 33 was be VBD cord-023095-4dannjjm 4696 34 used use VBN cord-023095-4dannjjm 4696 35 for for IN cord-023095-4dannjjm 4696 36 EC EC NNP cord-023095-4dannjjm 4696 37 . . . cord-023095-4dannjjm 4697 1 All all DT cord-023095-4dannjjm 4697 2 analyses analysis NNS cord-023095-4dannjjm 4697 3 were be VBD cord-023095-4dannjjm 4697 4 performed perform VBN cord-023095-4dannjjm 4697 5 using use VBG cord-023095-4dannjjm 4697 6 SAS SAS NNP cord-023095-4dannjjm 4697 7 V V NNP cord-023095-4dannjjm 4697 8 9.2 9.2 CD cord-023095-4dannjjm 4697 9 ( ( -LRB- cord-023095-4dannjjm 4697 10 Cary Cary NNP cord-023095-4dannjjm 4697 11 , , , cord-023095-4dannjjm 4697 12 NC NC NNP cord-023095-4dannjjm 4697 13 ) ) -RRB- cord-023095-4dannjjm 4697 14 . . . cord-023095-4dannjjm 4698 1 Descriptive descriptive JJ cord-023095-4dannjjm 4698 2 statistics statistic NNS cord-023095-4dannjjm 4698 3 of of IN cord-023095-4dannjjm 4698 4 staining stain VBG cord-023095-4dannjjm 4698 5 percentages percentage NNS cord-023095-4dannjjm 4698 6 were be VBD cord-023095-4dannjjm 4698 7 calculated calculate VBN cord-023095-4dannjjm 4698 8 for for IN cord-023095-4dannjjm 4698 9 all all DT cord-023095-4dannjjm 4698 10 tumors tumor NNS cord-023095-4dannjjm 4698 11 tested test VBN cord-023095-4dannjjm 4698 12 . . . cord-023095-4dannjjm 4699 1 Simple Simple NNP cord-023095-4dannjjm 4699 2 Pearson Pearson NNP cord-023095-4dannjjm 4699 3 's 's POS cord-023095-4dannjjm 4699 4 correlation correlation NN cord-023095-4dannjjm 4699 5 was be VBD cord-023095-4dannjjm 4699 6 used use VBN cord-023095-4dannjjm 4699 7 to to TO cord-023095-4dannjjm 4699 8 test test VB cord-023095-4dannjjm 4699 9 for for IN cord-023095-4dannjjm 4699 10 correlations correlation NNS cord-023095-4dannjjm 4699 11 of of IN cord-023095-4dannjjm 4699 12 EC EC NNP cord-023095-4dannjjm 4699 13 area area NN cord-023095-4dannjjm 4699 14 with with IN cord-023095-4dannjjm 4699 15 HSP HSP NNP cord-023095-4dannjjm 4699 16 areas area NNS cord-023095-4dannjjm 4699 17 and and CC cord-023095-4dannjjm 4699 18 Ki-67 Ki-67 NNP cord-023095-4dannjjm 4699 19 percent percent NN cord-023095-4dannjjm 4699 20 positive positive JJ cord-023095-4dannjjm 4699 21 cells cell NNS cord-023095-4dannjjm 4699 22 and and CC cord-023095-4dannjjm 4699 23 of of IN cord-023095-4dannjjm 4699 24 EC EC NNP cord-023095-4dannjjm 4699 25 intensity intensity NN cord-023095-4dannjjm 4699 26 with with IN cord-023095-4dannjjm 4699 27 HSP HSP NNP cord-023095-4dannjjm 4699 28 intensities intensity NNS cord-023095-4dannjjm 4699 29 and and CC cord-023095-4dannjjm 4699 30 Ki-67 Ki-67 NNP cord-023095-4dannjjm 4699 31 percent percent NN cord-023095-4dannjjm 4699 32 positive positive JJ cord-023095-4dannjjm 4699 33 cells cell NNS cord-023095-4dannjjm 4699 34 . . . cord-023095-4dannjjm 4700 1 All all DT cord-023095-4dannjjm 4700 2 hypothesis hypothesis NN cord-023095-4dannjjm 4700 3 tests test NNS cord-023095-4dannjjm 4700 4 were be VBD cord-023095-4dannjjm 4700 5 2sided 2sided CD cord-023095-4dannjjm 4700 6 and and CC cord-023095-4dannjjm 4700 7 the the DT cord-023095-4dannjjm 4700 8 significance significance NN cord-023095-4dannjjm 4700 9 level level NN cord-023095-4dannjjm 4700 10 was be VBD cord-023095-4dannjjm 4700 11 a a DT cord-023095-4dannjjm 4700 12 5 5 CD cord-023095-4dannjjm 4700 13 0.05 0.05 CD cord-023095-4dannjjm 4700 14 . . . cord-023095-4dannjjm 4701 1 Thirteen thirteen CD cord-023095-4dannjjm 4701 2 meningiomas meningiomas NN cord-023095-4dannjjm 4701 3 had have VBD cord-023095-4dannjjm 4701 4 MR MR NNP cord-023095-4dannjjm 4701 5 images image NNS cord-023095-4dannjjm 4701 6 quantitatively quantitatively RB cord-023095-4dannjjm 4701 7 evaluated evaluate VBN cord-023095-4dannjjm 4701 8 for for IN cord-023095-4dannjjm 4701 9 peritumoral peritumoral JJ cord-023095-4dannjjm 4701 10 edema edema NN cord-023095-4dannjjm 4701 11 using use VBG cord-023095-4dannjjm 4701 12 T2FLAIR T2FLAIR NNP cord-023095-4dannjjm 4701 13 sequences sequence NNS cord-023095-4dannjjm 4701 14 . . . cord-023095-4dannjjm 4702 1 The the DT cord-023095-4dannjjm 4702 2 edema edema NN cord-023095-4dannjjm 4702 3 index index NN cord-023095-4dannjjm 4702 4 ( ( -LRB- cord-023095-4dannjjm 4702 5 EI EI NNP cord-023095-4dannjjm 4702 6 ) ) -RRB- cord-023095-4dannjjm 4702 7 was be VBD cord-023095-4dannjjm 4702 8 evaluated evaluate VBN cord-023095-4dannjjm 4702 9 for for IN cord-023095-4dannjjm 4702 10 an an DT cord-023095-4dannjjm 4702 11 association association NN cord-023095-4dannjjm 4702 12 with with IN cord-023095-4dannjjm 4702 13 HSP HSP NNP cord-023095-4dannjjm 4702 14 27 27 CD cord-023095-4dannjjm 4702 15 , , , cord-023095-4dannjjm 4702 16 HSP HSP NNP cord-023095-4dannjjm 4702 17 72 72 CD cord-023095-4dannjjm 4702 18 , , , cord-023095-4dannjjm 4702 19 EC EC NNP cord-023095-4dannjjm 4702 20 and and CC cord-023095-4dannjjm 4702 21 Ki67 Ki67 NNP cord-023095-4dannjjm 4702 22 expression expression NN cord-023095-4dannjjm 4702 23 . . . cord-023095-4dannjjm 4703 1 HSP HSP NNP cord-023095-4dannjjm 4703 2 27 27 CD cord-023095-4dannjjm 4703 3 was be VBD cord-023095-4dannjjm 4703 4 expressed express VBN cord-023095-4dannjjm 4703 5 in in IN cord-023095-4dannjjm 4703 6 36 36 CD cord-023095-4dannjjm 4703 7 % % NN cord-023095-4dannjjm 4703 8 ( ( -LRB- cord-023095-4dannjjm 4703 9 mean mean VB cord-023095-4dannjjm 4703 10 8.7 8.7 CD cord-023095-4dannjjm 4703 11 % % NN cord-023095-4dannjjm 4703 12 of of IN cord-023095-4dannjjm 4703 13 cells cell NNS cord-023095-4dannjjm 4703 14 ; ; : cord-023095-4dannjjm 4703 15 range range VBP cord-023095-4dannjjm 4703 16 0 0 CD cord-023095-4dannjjm 4703 17 - - SYM cord-023095-4dannjjm 4703 18 58 58 CD cord-023095-4dannjjm 4703 19 % % NN cord-023095-4dannjjm 4703 20 ) ) -RRB- cord-023095-4dannjjm 4703 21 , , , cord-023095-4dannjjm 4703 22 HSP HSP NNP cord-023095-4dannjjm 4703 23 72 72 CD cord-023095-4dannjjm 4703 24 in in IN cord-023095-4dannjjm 4703 25 52 52 CD cord-023095-4dannjjm 4703 26 % % NN cord-023095-4dannjjm 4703 27 ( ( -LRB- cord-023095-4dannjjm 4703 28 mean mean VB cord-023095-4dannjjm 4703 29 5.2 5.2 CD cord-023095-4dannjjm 4703 30 % % NN cord-023095-4dannjjm 4703 31 of of IN cord-023095-4dannjjm 4703 32 cells cell NNS cord-023095-4dannjjm 4703 33 ; ; : cord-023095-4dannjjm 4703 34 range range VBP cord-023095-4dannjjm 4703 35 0 0 CD cord-023095-4dannjjm 4703 36 - - SYM cord-023095-4dannjjm 4703 37 26 26 CD cord-023095-4dannjjm 4703 38 % % NN cord-023095-4dannjjm 4703 39 ) ) -RRB- cord-023095-4dannjjm 4703 40 and and CC cord-023095-4dannjjm 4703 41 EC EC NNP cord-023095-4dannjjm 4703 42 in in IN cord-023095-4dannjjm 4703 43 68 68 CD cord-023095-4dannjjm 4703 44 % % NN cord-023095-4dannjjm 4703 45 of of IN cord-023095-4dannjjm 4703 46 meningiomas meningiomas NNP cord-023095-4dannjjm 4703 47 . . . cord-023095-4dannjjm 4704 1 There there EX cord-023095-4dannjjm 4704 2 was be VBD cord-023095-4dannjjm 4704 3 no no DT cord-023095-4dannjjm 4704 4 association association NN cord-023095-4dannjjm 4704 5 demonstrated demonstrate VBN cord-023095-4dannjjm 4704 6 between between IN cord-023095-4dannjjm 4704 7 either either CC cord-023095-4dannjjm 4704 8 HSP HSP NNP cord-023095-4dannjjm 4704 9 expression expression NN cord-023095-4dannjjm 4704 10 variable variable NN cord-023095-4dannjjm 4704 11 and and CC cord-023095-4dannjjm 4704 12 EC EC NNP cord-023095-4dannjjm 4704 13 or or CC cord-023095-4dannjjm 4704 14 Ki-67 Ki-67 NNP cord-023095-4dannjjm 4704 15 expression expression NN cord-023095-4dannjjm 4704 16 . . . cord-023095-4dannjjm 4705 1 There there EX cord-023095-4dannjjm 4705 2 was be VBD cord-023095-4dannjjm 4705 3 also also RB cord-023095-4dannjjm 4705 4 no no DT cord-023095-4dannjjm 4705 5 association association NN cord-023095-4dannjjm 4705 6 between between IN cord-023095-4dannjjm 4705 7 the the DT cord-023095-4dannjjm 4705 8 EC EC NNP cord-023095-4dannjjm 4705 9 expression expression NN cord-023095-4dannjjm 4705 10 variables variable NNS cord-023095-4dannjjm 4705 11 and and CC cord-023095-4dannjjm 4706 1 Ki-67 Ki-67 NNS cord-023095-4dannjjm 4706 2 . . . cord-023095-4dannjjm 4707 1 However however RB cord-023095-4dannjjm 4707 2 , , , cord-023095-4dannjjm 4707 3 there there EX cord-023095-4dannjjm 4707 4 was be VBD cord-023095-4dannjjm 4707 5 a a DT cord-023095-4dannjjm 4707 6 significant significant JJ cord-023095-4dannjjm 4707 7 negative negative JJ cord-023095-4dannjjm 4707 8 association association NN cord-023095-4dannjjm 4707 9 between between IN cord-023095-4dannjjm 4707 10 HSP HSP NNP cord-023095-4dannjjm 4707 11 72 72 CD cord-023095-4dannjjm 4707 12 extent extent NN cord-023095-4dannjjm 4707 13 ( ( -LRB- cord-023095-4dannjjm 4707 14 p p NN cord-023095-4dannjjm 4707 15 5 5 CD cord-023095-4dannjjm 4707 16 0.03 0.03 CD cord-023095-4dannjjm 4707 17 ) ) -RRB- cord-023095-4dannjjm 4707 18 and and CC cord-023095-4dannjjm 4707 19 area area NN cord-023095-4dannjjm 4707 20 ( ( -LRB- cord-023095-4dannjjm 4707 21 p p NN cord-023095-4dannjjm 4707 22 5 5 CD cord-023095-4dannjjm 4707 23 0.04 0.04 CD cord-023095-4dannjjm 4707 24 ) ) -RRB- cord-023095-4dannjjm 4707 25 with with IN cord-023095-4dannjjm 4707 26 EI EI NNP cord-023095-4dannjjm 4707 27 . . . cord-023095-4dannjjm 4708 1 In in IN cord-023095-4dannjjm 4708 2 conclusion conclusion NN cord-023095-4dannjjm 4708 3 , , , cord-023095-4dannjjm 4708 4 HSP HSP NNP cord-023095-4dannjjm 4708 5 27 27 CD cord-023095-4dannjjm 4708 6 and and CC cord-023095-4dannjjm 4708 7 72 72 CD cord-023095-4dannjjm 4708 8 expression expression NN cord-023095-4dannjjm 4708 9 was be VBD cord-023095-4dannjjm 4708 10 demonstrated demonstrate VBN cord-023095-4dannjjm 4708 11 in in IN cord-023095-4dannjjm 4708 12 canine canine JJ cord-023095-4dannjjm 4708 13 intracranial intracranial JJ cord-023095-4dannjjm 4708 14 meningiomas meningiomas NN cord-023095-4dannjjm 4708 15 but but CC cord-023095-4dannjjm 4708 16 was be VBD cord-023095-4dannjjm 4708 17 not not RB cord-023095-4dannjjm 4708 18 associated associate VBN cord-023095-4dannjjm 4708 19 with with IN cord-023095-4dannjjm 4708 20 Ki-67 Ki-67 NNPS cord-023095-4dannjjm 4708 21 or or CC cord-023095-4dannjjm 4708 22 EC EC NNP cord-023095-4dannjjm 4708 23 expression expression NN cord-023095-4dannjjm 4708 24 . . . cord-023095-4dannjjm 4709 1 This this DT cord-023095-4dannjjm 4709 2 study study NN cord-023095-4dannjjm 4709 3 suggests suggest VBZ cord-023095-4dannjjm 4709 4 that that IN cord-023095-4dannjjm 4709 5 HSPs hsp NNS cord-023095-4dannjjm 4709 6 may may MD cord-023095-4dannjjm 4709 7 not not RB cord-023095-4dannjjm 4709 8 have have VB cord-023095-4dannjjm 4709 9 a a DT cord-023095-4dannjjm 4709 10 significant significant JJ cord-023095-4dannjjm 4709 11 role role NN cord-023095-4dannjjm 4709 12 in in IN cord-023095-4dannjjm 4709 13 the the DT cord-023095-4dannjjm 4709 14 maintenance maintenance NN cord-023095-4dannjjm 4709 15 of of IN cord-023095-4dannjjm 4709 16 canine canine JJ cord-023095-4dannjjm 4709 17 meningiomas meningiomas NN cord-023095-4dannjjm 4709 18 and and CC cord-023095-4dannjjm 4709 19 so so RB cord-023095-4dannjjm 4709 20 do do VB cord-023095-4dannjjm 4709 21 not not RB cord-023095-4dannjjm 4709 22 represent represent VB cord-023095-4dannjjm 4709 23 a a DT cord-023095-4dannjjm 4709 24 novel novel JJ cord-023095-4dannjjm 4709 25 treatment treatment NN cord-023095-4dannjjm 4709 26 target target NN cord-023095-4dannjjm 4709 27 for for IN cord-023095-4dannjjm 4709 28 this this DT cord-023095-4dannjjm 4709 29 group group NN cord-023095-4dannjjm 4709 30 of of IN cord-023095-4dannjjm 4709 31 tumors tumor NNS cord-023095-4dannjjm 4709 32 unlike unlike IN cord-023095-4dannjjm 4709 33 canine canine JJ cord-023095-4dannjjm 4709 34 glial glial JJ cord-023095-4dannjjm 4709 35 cell cell NN cord-023095-4dannjjm 4709 36 tumors tumor NNS cord-023095-4dannjjm 4709 37 . . . cord-023095-4dannjjm 4710 1 However however RB cord-023095-4dannjjm 4710 2 , , , cord-023095-4dannjjm 4710 3 HSP HSP NNP cord-023095-4dannjjm 4710 4 72 72 CD cord-023095-4dannjjm 4710 5 may may MD cord-023095-4dannjjm 4710 6 be be VB cord-023095-4dannjjm 4710 7 involved involve VBN cord-023095-4dannjjm 4710 8 in in IN cord-023095-4dannjjm 4710 9 the the DT cord-023095-4dannjjm 4710 10 pathogenesis pathogenesis NN cord-023095-4dannjjm 4710 11 of of IN cord-023095-4dannjjm 4710 12 peritumoral peritumoral JJ cord-023095-4dannjjm 4710 13 edema edema NN cord-023095-4dannjjm 4710 14 in in IN cord-023095-4dannjjm 4710 15 meningiomas meningiomas NNP cord-023095-4dannjjm 4710 16 and and CC cord-023095-4dannjjm 4710 17 warrants warrant NNS cord-023095-4dannjjm 4710 18 further further JJ cord-023095-4dannjjm 4710 19 investigation investigation NN cord-023095-4dannjjm 4710 20 . . . cord-023095-4dannjjm 4711 1 An an DT cord-023095-4dannjjm 4711 2 extended extended JJ cord-023095-4dannjjm 4711 3 release release NN cord-023095-4dannjjm 4711 4 ( ( -LRB- cord-023095-4dannjjm 4711 5 XR XR NNP cord-023095-4dannjjm 4711 6 ) ) -RRB- cord-023095-4dannjjm 4711 7 formulation formulation NN cord-023095-4dannjjm 4711 8 of of IN cord-023095-4dannjjm 4711 9 levetiracetam levetiracetam NNP cord-023095-4dannjjm 4711 10 , , , cord-023095-4dannjjm 4711 11 a a DT cord-023095-4dannjjm 4711 12 second second JJ cord-023095-4dannjjm 4711 13 generation generation NN cord-023095-4dannjjm 4711 14 antiepileptic antiepileptic JJ cord-023095-4dannjjm 4711 15 drug drug NN cord-023095-4dannjjm 4711 16 , , , cord-023095-4dannjjm 4711 17 was be VBD cord-023095-4dannjjm 4711 18 recently recently RB cord-023095-4dannjjm 4711 19 approved approve VBN cord-023095-4dannjjm 4711 20 for for IN cord-023095-4dannjjm 4711 21 human human JJ cord-023095-4dannjjm 4711 22 use use NN cord-023095-4dannjjm 4711 23 on on IN cord-023095-4dannjjm 4711 24 a a DT cord-023095-4dannjjm 4711 25 once once RB cord-023095-4dannjjm 4711 26 daily daily JJ cord-023095-4dannjjm 4711 27 basis basis NN cord-023095-4dannjjm 4711 28 . . . cord-023095-4dannjjm 4712 1 Although although IN cord-023095-4dannjjm 4712 2 levetiracetam levetiracetam NNP cord-023095-4dannjjm 4712 3 is be VBZ cord-023095-4dannjjm 4712 4 clinically clinically RB cord-023095-4dannjjm 4712 5 effective effective JJ cord-023095-4dannjjm 4712 6 for for IN cord-023095-4dannjjm 4712 7 seizure seizure NN cord-023095-4dannjjm 4712 8 control control NN cord-023095-4dannjjm 4712 9 in in IN cord-023095-4dannjjm 4712 10 dogs dog NNS cord-023095-4dannjjm 4712 11 , , , cord-023095-4dannjjm 4712 12 it -PRON- PRP cord-023095-4dannjjm 4712 13 requires require VBZ cord-023095-4dannjjm 4712 14 a a DT cord-023095-4dannjjm 4712 15 three three CD cord-023095-4dannjjm 4712 16 times time NNS cord-023095-4dannjjm 4712 17 daily daily JJ cord-023095-4dannjjm 4712 18 administration administration NN cord-023095-4dannjjm 4712 19 . . . cord-023095-4dannjjm 4713 1 The the DT cord-023095-4dannjjm 4713 2 potential potential JJ cord-023095-4dannjjm 4713 3 benefits benefit NNS cord-023095-4dannjjm 4713 4 of of IN cord-023095-4dannjjm 4713 5 the the DT cord-023095-4dannjjm 4713 6 XR XR NNP cord-023095-4dannjjm 4713 7 formulation formulation NN cord-023095-4dannjjm 4713 8 include include VBP cord-023095-4dannjjm 4713 9 reduced reduce VBN cord-023095-4dannjjm 4713 10 daily daily RB cord-023095-4dannjjm 4713 11 dosing dose VBG cord-023095-4dannjjm 4713 12 leading lead VBG cord-023095-4dannjjm 4713 13 to to IN cord-023095-4dannjjm 4713 14 improved improved JJ cord-023095-4dannjjm 4713 15 compliance compliance NN cord-023095-4dannjjm 4713 16 and and CC cord-023095-4dannjjm 4713 17 relatively relatively RB cord-023095-4dannjjm 4713 18 constant constant JJ cord-023095-4dannjjm 4713 19 plasma plasma NN cord-023095-4dannjjm 4713 20 concentrations concentration NNS cord-023095-4dannjjm 4713 21 . . . cord-023095-4dannjjm 4714 1 The the DT cord-023095-4dannjjm 4714 2 aim aim NN cord-023095-4dannjjm 4714 3 of of IN cord-023095-4dannjjm 4714 4 this this DT cord-023095-4dannjjm 4714 5 study study NN cord-023095-4dannjjm 4714 6 was be VBD cord-023095-4dannjjm 4714 7 to to TO cord-023095-4dannjjm 4714 8 compare compare VB cord-023095-4dannjjm 4714 9 the the DT cord-023095-4dannjjm 4714 10 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 4714 11 of of IN cord-023095-4dannjjm 4714 12 levetiracetam levetiracetam NNP cord-023095-4dannjjm 4714 13 XR XR NNP cord-023095-4dannjjm 4714 14 tablets tablet NNS cord-023095-4dannjjm 4714 15 with with IN cord-023095-4dannjjm 4714 16 immediate immediate JJ cord-023095-4dannjjm 4714 17 release release NN cord-023095-4dannjjm 4714 18 ( ( -LRB- cord-023095-4dannjjm 4714 19 IR IR NNP cord-023095-4dannjjm 4714 20 ) ) -RRB- cord-023095-4dannjjm 4714 21 tablets tablet NNS cord-023095-4dannjjm 4714 22 following follow VBG cord-023095-4dannjjm 4714 23 single single JJ cord-023095-4dannjjm 4714 24 dosing dosing NN cord-023095-4dannjjm 4714 25 in in IN cord-023095-4dannjjm 4714 26 dogs dog NNS cord-023095-4dannjjm 4714 27 . . . cord-023095-4dannjjm 4715 1 Five five CD cord-023095-4dannjjm 4715 2 clinically clinically RB cord-023095-4dannjjm 4715 3 and and CC cord-023095-4dannjjm 4715 4 neurologically neurologically RB cord-023095-4dannjjm 4715 5 normal normal JJ cord-023095-4dannjjm 4715 6 mixed mixed JJ cord-023095-4dannjjm 4715 7 breed breed NN cord-023095-4dannjjm 4715 8 dogs dog NNS cord-023095-4dannjjm 4715 9 were be VBD cord-023095-4dannjjm 4715 10 used use VBN cord-023095-4dannjjm 4715 11 in in IN cord-023095-4dannjjm 4715 12 a a DT cord-023095-4dannjjm 4715 13 cross cross NN cord-023095-4dannjjm 4715 14 - - HYPH cord-023095-4dannjjm 4715 15 over over RP cord-023095-4dannjjm 4715 16 design design NN cord-023095-4dannjjm 4715 17 . . . cord-023095-4dannjjm 4716 1 All all DT cord-023095-4dannjjm 4716 2 dogs dog NNS cord-023095-4dannjjm 4716 3 ( ( -LRB- cord-023095-4dannjjm 4716 4 mean mean VB cord-023095-4dannjjm 4716 5 body body NN cord-023095-4dannjjm 4716 6 weight weight NN cord-023095-4dannjjm 4716 7 25.9 25.9 CD cord-023095-4dannjjm 4716 8 kg kg NNS cord-023095-4dannjjm 4716 9 ; ; : cord-023095-4dannjjm 4716 10 range range VBP cord-023095-4dannjjm 4716 11 23.2 23.2 CD cord-023095-4dannjjm 4716 12 - - HYPH cord-023095-4dannjjm 4716 13 30.5 30.5 CD cord-023095-4dannjjm 4716 14 ) ) -RRB- cord-023095-4dannjjm 4716 15 had have VBD cord-023095-4dannjjm 4716 16 normal normal JJ cord-023095-4dannjjm 4716 17 hematology hematology NN cord-023095-4dannjjm 4716 18 , , , cord-023095-4dannjjm 4716 19 serum serum NN cord-023095-4dannjjm 4716 20 chemistry chemistry NN cord-023095-4dannjjm 4716 21 and and CC cord-023095-4dannjjm 4716 22 urinalyses urinalysis NNS cord-023095-4dannjjm 4716 23 . . . cord-023095-4dannjjm 4717 1 Following follow VBG cord-023095-4dannjjm 4717 2 a a DT cord-023095-4dannjjm 4717 3 12 12 CD cord-023095-4dannjjm 4717 4 hour hour NN cord-023095-4dannjjm 4717 5 fast fast RB cord-023095-4dannjjm 4717 6 , , , cord-023095-4dannjjm 4717 7 each each DT cord-023095-4dannjjm 4717 8 dog dog NN cord-023095-4dannjjm 4717 9 was be VBD cord-023095-4dannjjm 4717 10 administered administer VBN cord-023095-4dannjjm 4717 11 oral oral JJ cord-023095-4dannjjm 4717 12 IR IR NNP cord-023095-4dannjjm 4717 13 levetiracetam levetiracetam NNP cord-023095-4dannjjm 4717 14 ( ( -LRB- cord-023095-4dannjjm 4717 15 500 500 CD cord-023095-4dannjjm 4717 16 mg mg NN cord-023095-4dannjjm 4717 17 ; ; : cord-023095-4dannjjm 4717 18 mean mean VB cord-023095-4dannjjm 4717 19 dose dose NN cord-023095-4dannjjm 4717 20 19.3 19.3 CD cord-023095-4dannjjm 4717 21 mg mg NNP cord-023095-4dannjjm 4717 22 / / SYM cord-023095-4dannjjm 4717 23 kg kg NNP cord-023095-4dannjjm 4717 24 ; ; : cord-023095-4dannjjm 4717 25 range range VBP cord-023095-4dannjjm 4717 26 16.4 16.4 CD cord-023095-4dannjjm 4717 27 - - HYPH cord-023095-4dannjjm 4717 28 21.6 21.6 CD cord-023095-4dannjjm 4717 29 ) ) -RRB- cord-023095-4dannjjm 4717 30 . . . cord-023095-4dannjjm 4718 1 Heparinized heparinize VBN cord-023095-4dannjjm 4718 2 blood blood NN cord-023095-4dannjjm 4718 3 for for IN cord-023095-4dannjjm 4718 4 drug drug NN cord-023095-4dannjjm 4718 5 analysis analysis NN cord-023095-4dannjjm 4718 6 was be VBD cord-023095-4dannjjm 4718 7 taken take VBN cord-023095-4dannjjm 4718 8 from from IN cord-023095-4dannjjm 4718 9 each each DT cord-023095-4dannjjm 4718 10 dog dog NN cord-023095-4dannjjm 4718 11 prior prior RB cord-023095-4dannjjm 4718 12 to to IN cord-023095-4dannjjm 4718 13 administration administration NN cord-023095-4dannjjm 4718 14 and and CC cord-023095-4dannjjm 4718 15 0.25 0.25 CD cord-023095-4dannjjm 4718 16 , , , cord-023095-4dannjjm 4718 17 0.5 0.5 CD cord-023095-4dannjjm 4718 18 , , , cord-023095-4dannjjm 4718 19 0.75 0.75 CD cord-023095-4dannjjm 4718 20 , , , cord-023095-4dannjjm 4718 21 1 1 CD cord-023095-4dannjjm 4718 22 , , , cord-023095-4dannjjm 4718 23 2 2 CD cord-023095-4dannjjm 4718 24 , , , cord-023095-4dannjjm 4718 25 4 4 CD cord-023095-4dannjjm 4718 26 and and CC cord-023095-4dannjjm 4718 27 8 8 CD cord-023095-4dannjjm 4718 28 hours hour NNS cord-023095-4dannjjm 4718 29 after after RB cord-023095-4dannjjm 4718 30 . . . cord-023095-4dannjjm 4719 1 Blood blood NN cord-023095-4dannjjm 4719 2 was be VBD cord-023095-4dannjjm 4719 3 immediately immediately RB cord-023095-4dannjjm 4719 4 centrifuged centrifuge VBN cord-023095-4dannjjm 4719 5 and and CC cord-023095-4dannjjm 4719 6 supernatant supernatant JJ cord-023095-4dannjjm 4719 7 plasma plasma NN cord-023095-4dannjjm 4719 8 was be VBD cord-023095-4dannjjm 4719 9 stored store VBN cord-023095-4dannjjm 4719 10 at at IN cord-023095-4dannjjm 4719 11 À801C À801C NNPS cord-023095-4dannjjm 4719 12 until until IN cord-023095-4dannjjm 4719 13 analysis analysis NN cord-023095-4dannjjm 4719 14 . . . cord-023095-4dannjjm 4720 1 After after IN cord-023095-4dannjjm 4720 2 a a DT cord-023095-4dannjjm 4720 3 4 4 CD cord-023095-4dannjjm 4720 4 day day NN cord-023095-4dannjjm 4720 5 wash wash NN cord-023095-4dannjjm 4720 6 - - HYPH cord-023095-4dannjjm 4720 7 out out RP cord-023095-4dannjjm 4720 8 period period NN cord-023095-4dannjjm 4720 9 , , , cord-023095-4dannjjm 4720 10 each each DT cord-023095-4dannjjm 4720 11 dog dog NN cord-023095-4dannjjm 4720 12 was be VBD cord-023095-4dannjjm 4720 13 administered administer VBN cord-023095-4dannjjm 4720 14 500 500 CD cord-023095-4dannjjm 4720 15 mg mg NNP cord-023095-4dannjjm 4720 16 oral oral JJ cord-023095-4dannjjm 4720 17 XR XR NNP cord-023095-4dannjjm 4720 18 levetiracetam levetiracetam NNS cord-023095-4dannjjm 4720 19 and and CC cord-023095-4dannjjm 4720 20 blood blood NN cord-023095-4dannjjm 4720 21 samples sample NNS cord-023095-4dannjjm 4720 22 were be VBD cord-023095-4dannjjm 4720 23 taken take VBN cord-023095-4dannjjm 4720 24 at at IN cord-023095-4dannjjm 4720 25 identical identical JJ cord-023095-4dannjjm 4720 26 timings timing NNS cord-023095-4dannjjm 4720 27 . . . cord-023095-4dannjjm 4721 1 Plasma plasma NN cord-023095-4dannjjm 4721 2 samples sample NNS cord-023095-4dannjjm 4721 3 were be VBD cord-023095-4dannjjm 4721 4 thawed thaw VBN cord-023095-4dannjjm 4721 5 at at IN cord-023095-4dannjjm 4721 6 room room NN cord-023095-4dannjjm 4721 7 temperature temperature NN cord-023095-4dannjjm 4721 8 before before IN cord-023095-4dannjjm 4721 9 preparation preparation NN cord-023095-4dannjjm 4721 10 by by IN cord-023095-4dannjjm 4721 11 solid solid JJ cord-023095-4dannjjm 4721 12 phase phase NN cord-023095-4dannjjm 4721 13 extraction extraction NN cord-023095-4dannjjm 4721 14 for for IN cord-023095-4dannjjm 4721 15 HPLC HPLC NNP cord-023095-4dannjjm 4721 16 analysis analysis NN cord-023095-4dannjjm 4721 17 . . . cord-023095-4dannjjm 4722 1 Reverse reverse JJ cord-023095-4dannjjm 4722 2 phase phase NN cord-023095-4dannjjm 4722 3 chromatographic chromatographic JJ cord-023095-4dannjjm 4722 4 separation separation NN cord-023095-4dannjjm 4722 5 was be VBD cord-023095-4dannjjm 4722 6 performed perform VBN cord-023095-4dannjjm 4722 7 . . . cord-023095-4dannjjm 4723 1 Levetiracetam Levetiracetam NNS cord-023095-4dannjjm 4723 2 and and CC cord-023095-4dannjjm 4723 3 an an DT cord-023095-4dannjjm 4723 4 internal internal JJ cord-023095-4dannjjm 4723 5 standard standard NN cord-023095-4dannjjm 4723 6 were be VBD cord-023095-4dannjjm 4723 7 detected detect VBN cord-023095-4dannjjm 4723 8 using use VBG cord-023095-4dannjjm 4723 9 ultraviolet ultraviolet NN cord-023095-4dannjjm 4723 10 spectroscopy spectroscopy NN cord-023095-4dannjjm 4723 11 at at IN cord-023095-4dannjjm 4723 12 205 205 CD cord-023095-4dannjjm 4723 13 nm nm NN cord-023095-4dannjjm 4723 14 . . . cord-023095-4dannjjm 4724 1 Concentrations concentration NNS cord-023095-4dannjjm 4724 2 of of IN cord-023095-4dannjjm 4724 3 levetiracetam levetiracetam NNS cord-023095-4dannjjm 4724 4 were be VBD cord-023095-4dannjjm 4724 5 determined determine VBN cord-023095-4dannjjm 4724 6 by by IN cord-023095-4dannjjm 4724 7 peak peak NN cord-023095-4dannjjm 4724 8 area area NN cord-023095-4dannjjm 4724 9 comparison comparison NN cord-023095-4dannjjm 4724 10 to to IN cord-023095-4dannjjm 4724 11 the the DT cord-023095-4dannjjm 4724 12 internal internal JJ cord-023095-4dannjjm 4724 13 standard standard NN cord-023095-4dannjjm 4724 14 . . . cord-023095-4dannjjm 4725 1 Mean mean JJ cord-023095-4dannjjm 4725 2 data datum NNS cord-023095-4dannjjm 4725 3 were be VBD cord-023095-4dannjjm 4725 4 fit fit JJ cord-023095-4dannjjm 4725 5 to to IN cord-023095-4dannjjm 4725 6 a a DT cord-023095-4dannjjm 4725 7 one one CD cord-023095-4dannjjm 4725 8 compartment compartment NN cord-023095-4dannjjm 4725 9 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 4725 10 model model NN cord-023095-4dannjjm 4725 11 with with IN cord-023095-4dannjjm 4725 12 first first JJ cord-023095-4dannjjm 4725 13 order order NN cord-023095-4dannjjm 4725 14 elimination elimination NN cord-023095-4dannjjm 4725 15 and and CC cord-023095-4dannjjm 4725 16 absorption absorption NN cord-023095-4dannjjm 4725 17 and and CC cord-023095-4dannjjm 4725 18 included include VBD cord-023095-4dannjjm 4725 19 a a DT cord-023095-4dannjjm 4725 20 lag lag NN cord-023095-4dannjjm 4725 21 - - HYPH cord-023095-4dannjjm 4725 22 phase phase NN cord-023095-4dannjjm 4725 23 for for IN cord-023095-4dannjjm 4725 24 XR XR NNP cord-023095-4dannjjm 4725 25 formulation formulation NN cord-023095-4dannjjm 4725 26 . . . cord-023095-4dannjjm 4726 1 No no DT cord-023095-4dannjjm 4726 2 adverse adverse JJ cord-023095-4dannjjm 4726 3 clinical clinical JJ cord-023095-4dannjjm 4726 4 effects effect NNS cord-023095-4dannjjm 4726 5 were be VBD cord-023095-4dannjjm 4726 6 noted note VBN cord-023095-4dannjjm 4726 7 in in IN cord-023095-4dannjjm 4726 8 any any DT cord-023095-4dannjjm 4726 9 of of IN cord-023095-4dannjjm 4726 10 the the DT cord-023095-4dannjjm 4726 11 dogs dog NNS cord-023095-4dannjjm 4726 12 . . . cord-023095-4dannjjm 4727 1 The the DT cord-023095-4dannjjm 4727 2 AUC AUC NNP cord-023095-4dannjjm 4727 3 associated associate VBN cord-023095-4dannjjm 4727 4 with with IN cord-023095-4dannjjm 4727 5 XR XR NNP cord-023095-4dannjjm 4727 6 was be VBD cord-023095-4dannjjm 4727 7 230 230 CD cord-023095-4dannjjm 4727 8 hr hr NN cord-023095-4dannjjm 4727 9 ug ug NNP cord-023095-4dannjjm 4727 10 / / SYM cord-023095-4dannjjm 4727 11 mL mL NNP cord-023095-4dannjjm 4727 12 , , , cord-023095-4dannjjm 4727 13 a a DT cord-023095-4dannjjm 4727 14 5.14 5.14 CD cord-023095-4dannjjm 4727 15 fold fold NN cord-023095-4dannjjm 4727 16 increase increase NN cord-023095-4dannjjm 4727 17 over over IN cord-023095-4dannjjm 4727 18 that that DT cord-023095-4dannjjm 4727 19 with with IN cord-023095-4dannjjm 4727 20 IR IR NNP cord-023095-4dannjjm 4727 21 ( ( -LRB- cord-023095-4dannjjm 4727 22 44.8 44.8 CD cord-023095-4dannjjm 4727 23 hr hr NN cord-023095-4dannjjm 4727 24 ug ug NNP cord-023095-4dannjjm 4727 25 / / SYM cord-023095-4dannjjm 4727 26 mL mL NNP cord-023095-4dannjjm 4727 27 ) ) -RRB- cord-023095-4dannjjm 4727 28 . . . cord-023095-4dannjjm 4728 1 The the DT cord-023095-4dannjjm 4728 2 absorption absorption NN cord-023095-4dannjjm 4728 3 half half JJ cord-023095-4dannjjm 4728 4 - - HYPH cord-023095-4dannjjm 4728 5 life life NN cord-023095-4dannjjm 4728 6 was be VBD cord-023095-4dannjjm 4728 7 3.2 3.2 CD cord-023095-4dannjjm 4728 8 hr hr NN cord-023095-4dannjjm 4728 9 with with IN cord-023095-4dannjjm 4728 10 XR XR NNP cord-023095-4dannjjm 4728 11 and and CC cord-023095-4dannjjm 4728 12 0.41 0.41 CD cord-023095-4dannjjm 4728 13 hr hr NN cord-023095-4dannjjm 4728 14 with with IN cord-023095-4dannjjm 4728 15 IR IR NNP cord-023095-4dannjjm 4728 16 , , , cord-023095-4dannjjm 4728 17 a a DT cord-023095-4dannjjm 4728 18 7.75 7.75 CD cord-023095-4dannjjm 4728 19 fold fold JJ cord-023095-4dannjjm 4728 20 difference difference NN cord-023095-4dannjjm 4728 21 . . . cord-023095-4dannjjm 4729 1 The the DT cord-023095-4dannjjm 4729 2 elimination elimination NN cord-023095-4dannjjm 4729 3 halflife halflife NN cord-023095-4dannjjm 4729 4 was be VBD cord-023095-4dannjjm 4729 5 3.13 3.13 CD cord-023095-4dannjjm 4729 6 hr hr NN cord-023095-4dannjjm 4729 7 with with IN cord-023095-4dannjjm 4729 8 XR XR NNP cord-023095-4dannjjm 4729 9 and and CC cord-023095-4dannjjm 4729 10 2.19hr 2.19hr CD cord-023095-4dannjjm 4729 11 with with IN cord-023095-4dannjjm 4729 12 IR IR NNP cord-023095-4dannjjm 4729 13 , , , cord-023095-4dannjjm 4729 14 a a DT cord-023095-4dannjjm 4729 15 1.43 1.43 CD cord-023095-4dannjjm 4729 16 fold fold NN cord-023095-4dannjjm 4729 17 difference difference NN cord-023095-4dannjjm 4729 18 . . . cord-023095-4dannjjm 4730 1 The the DT cord-023095-4dannjjm 4730 2 Tmax Tmax NNP cord-023095-4dannjjm 4730 3 associated associate VBD cord-023095-4dannjjm 4730 4 with with IN cord-023095-4dannjjm 4730 5 XR XR NNP cord-023095-4dannjjm 4730 6 5.01 5.01 CD cord-023095-4dannjjm 4730 7 hr hr NN cord-023095-4dannjjm 4730 8 and and CC cord-023095-4dannjjm 4730 9 1.22 1.22 CD cord-023095-4dannjjm 4730 10 hr hr NN cord-023095-4dannjjm 4730 11 with with IN cord-023095-4dannjjm 4730 12 IR IR NNP cord-023095-4dannjjm 4730 13 , , , cord-023095-4dannjjm 4730 14 a a DT cord-023095-4dannjjm 4730 15 4.21 4.21 CD cord-023095-4dannjjm 4730 16 fold fold JJ cord-023095-4dannjjm 4730 17 difference difference NN cord-023095-4dannjjm 4730 18 . . . cord-023095-4dannjjm 4731 1 The the DT cord-023095-4dannjjm 4731 2 Cmax Cmax NNP cord-023095-4dannjjm 4731 3 associated associate VBD cord-023095-4dannjjm 4731 4 with with IN cord-023095-4dannjjm 4731 5 XR XR NNP cord-023095-4dannjjm 4731 6 was be VBD cord-023095-4dannjjm 4731 7 18.5 18.5 CD cord-023095-4dannjjm 4731 8 mg mg NNP cord-023095-4dannjjm 4731 9 / / SYM cord-023095-4dannjjm 4731 10 mL mL NNP cord-023095-4dannjjm 4731 11 and and CC cord-023095-4dannjjm 4731 12 9.62 9.62 CD cord-023095-4dannjjm 4731 13 mg mg NNP cord-023095-4dannjjm 4731 14 / / SYM cord-023095-4dannjjm 4731 15 mL ml NN cord-023095-4dannjjm 4731 16 with with IN cord-023095-4dannjjm 4731 17 IR IR NNP cord-023095-4dannjjm 4731 18 , , , cord-023095-4dannjjm 4731 19 a a DT cord-023095-4dannjjm 4731 20 1.92 1.92 CD cord-023095-4dannjjm 4731 21 fold fold NN cord-023095-4dannjjm 4731 22 difference difference NN cord-023095-4dannjjm 4731 23 . . . cord-023095-4dannjjm 4732 1 The the DT cord-023095-4dannjjm 4732 2 plasma plasma NN cord-023095-4dannjjm 4732 3 concentration concentration NN cord-023095-4dannjjm 4732 4 of of IN cord-023095-4dannjjm 4732 5 IR IR NNP cord-023095-4dannjjm 4732 6 levetiracetam levetiracetam NNP cord-023095-4dannjjm 4732 7 was be VBD cord-023095-4dannjjm 4732 8 not not RB cord-023095-4dannjjm 4732 9 detectable detectable JJ cord-023095-4dannjjm 4732 10 at at IN cord-023095-4dannjjm 4732 11 8hr 8hr NN cord-023095-4dannjjm 4732 12 after after IN cord-023095-4dannjjm 4732 13 administration administration NN cord-023095-4dannjjm 4732 14 whereas whereas IN cord-023095-4dannjjm 4732 15 it -PRON- PRP cord-023095-4dannjjm 4732 16 was be VBD cord-023095-4dannjjm 4732 17 greater great JJR cord-023095-4dannjjm 4732 18 than than IN cord-023095-4dannjjm 4732 19 10 10 CD cord-023095-4dannjjm 4732 20 mg mg NN cord-023095-4dannjjm 4732 21 / / SYM cord-023095-4dannjjm 4732 22 mL ml NN cord-023095-4dannjjm 4732 23 at at IN cord-023095-4dannjjm 4732 24 8hr 8hr NN cord-023095-4dannjjm 4732 25 after after IN cord-023095-4dannjjm 4732 26 XR XR NNP cord-023095-4dannjjm 4732 27 administration administration NN cord-023095-4dannjjm 4732 28 . . . cord-023095-4dannjjm 4733 1 Based base VBN cord-023095-4dannjjm 4733 2 on on IN cord-023095-4dannjjm 4733 3 the the DT cord-023095-4dannjjm 4733 4 AUC AUC NNP cord-023095-4dannjjm 4733 5 data datum NNS cord-023095-4dannjjm 4733 6 , , , cord-023095-4dannjjm 4733 7 there there EX cord-023095-4dannjjm 4733 8 is be VBZ cord-023095-4dannjjm 4733 9 an an DT cord-023095-4dannjjm 4733 10 approximately approximately RB cord-023095-4dannjjm 4733 11 5 5 CD cord-023095-4dannjjm 4733 12 fold fold JJ cord-023095-4dannjjm 4733 13 increase increase NN cord-023095-4dannjjm 4733 14 in in IN cord-023095-4dannjjm 4733 15 bioavailability bioavailability NN cord-023095-4dannjjm 4733 16 of of IN cord-023095-4dannjjm 4733 17 the the DT cord-023095-4dannjjm 4733 18 XR XR NNP cord-023095-4dannjjm 4733 19 compared compare VBN cord-023095-4dannjjm 4733 20 to to IN cord-023095-4dannjjm 4733 21 the the DT cord-023095-4dannjjm 4733 22 IR IR NNP cord-023095-4dannjjm 4733 23 formulation formulation NN cord-023095-4dannjjm 4733 24 . . . cord-023095-4dannjjm 4734 1 The the DT cord-023095-4dannjjm 4734 2 Cmax Cmax NNP cord-023095-4dannjjm 4734 3 was be VBD cord-023095-4dannjjm 4734 4 approximately approximately RB cord-023095-4dannjjm 4734 5 2 2 CD cord-023095-4dannjjm 4734 6 times time NNS cord-023095-4dannjjm 4734 7 greater great JJR cord-023095-4dannjjm 4734 8 following follow VBG cord-023095-4dannjjm 4734 9 XR XR NNP cord-023095-4dannjjm 4734 10 administration administration NN cord-023095-4dannjjm 4734 11 and and CC cord-023095-4dannjjm 4734 12 a a DT cord-023095-4dannjjm 4734 13 high high JJ cord-023095-4dannjjm 4734 14 plasma plasma NN cord-023095-4dannjjm 4734 15 level level NN cord-023095-4dannjjm 4734 16 in in IN cord-023095-4dannjjm 4734 17 excess excess NN cord-023095-4dannjjm 4734 18 of of IN cord-023095-4dannjjm 4734 19 the the DT cord-023095-4dannjjm 4734 20 suggested suggest VBN cord-023095-4dannjjm 4734 21 canine canine JJ cord-023095-4dannjjm 4734 22 therapeutic therapeutic JJ cord-023095-4dannjjm 4734 23 concentration concentration NN cord-023095-4dannjjm 4734 24 ( ( -LRB- cord-023095-4dannjjm 4734 25 5 5 CD cord-023095-4dannjjm 4734 26 mg mg NNP cord-023095-4dannjjm 4734 27 / / SYM cord-023095-4dannjjm 4734 28 mL mL NNP cord-023095-4dannjjm 4734 29 ) ) -RRB- cord-023095-4dannjjm 4734 30 for for IN cord-023095-4dannjjm 4734 31 at at RB cord-023095-4dannjjm 4734 32 least least JJS cord-023095-4dannjjm 4734 33 8 8 CD cord-023095-4dannjjm 4734 34 hours hour NNS cord-023095-4dannjjm 4734 35 . . . cord-023095-4dannjjm 4735 1 Although although IN cord-023095-4dannjjm 4735 2 specific specific JJ cord-023095-4dannjjm 4735 3 dosing dosing NN cord-023095-4dannjjm 4735 4 recommendations recommendation NNS cord-023095-4dannjjm 4735 5 can can MD cord-023095-4dannjjm 4735 6 not not RB cord-023095-4dannjjm 4735 7 be be VB cord-023095-4dannjjm 4735 8 made make VBN cord-023095-4dannjjm 4735 9 from from IN cord-023095-4dannjjm 4735 10 this this DT cord-023095-4dannjjm 4735 11 data data NN cord-023095-4dannjjm 4735 12 , , , cord-023095-4dannjjm 4735 13 the the DT cord-023095-4dannjjm 4735 14 favorable favorable JJ cord-023095-4dannjjm 4735 15 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 4735 16 of of IN cord-023095-4dannjjm 4735 17 XR XR NNP cord-023095-4dannjjm 4735 18 over over IN cord-023095-4dannjjm 4735 19 IR IR NNP cord-023095-4dannjjm 4735 20 suggests suggest VBZ cord-023095-4dannjjm 4735 21 that that IN cord-023095-4dannjjm 4735 22 single single JJ cord-023095-4dannjjm 4735 23 , , , cord-023095-4dannjjm 4735 24 daily daily JJ cord-023095-4dannjjm 4735 25 administration administration NN cord-023095-4dannjjm 4735 26 could could MD cord-023095-4dannjjm 4735 27 be be VB cord-023095-4dannjjm 4735 28 efficacious efficacious JJ cord-023095-4dannjjm 4735 29 . . . cord-023095-4dannjjm 4736 1 Thoracic thoracic JJ cord-023095-4dannjjm 4736 2 and and CC cord-023095-4dannjjm 4736 3 lumbar lumbar JJ cord-023095-4dannjjm 4736 4 vertebrae vertebra NNS cord-023095-4dannjjm 4736 5 are be VBP cord-023095-4dannjjm 4736 6 frequently frequently RB cord-023095-4dannjjm 4736 7 affected affect VBN cord-023095-4dannjjm 4736 8 by by IN cord-023095-4dannjjm 4736 9 fractures fracture NNS cord-023095-4dannjjm 4736 10 and and CC cord-023095-4dannjjm 4736 11 or or CC cord-023095-4dannjjm 4736 12 luxations luxation NNS cord-023095-4dannjjm 4736 13 in in IN cord-023095-4dannjjm 4736 14 dogs dog NNS cord-023095-4dannjjm 4736 15 following follow VBG cord-023095-4dannjjm 4736 16 trauma trauma NN cord-023095-4dannjjm 4736 17 . . . cord-023095-4dannjjm 4737 1 Surgical surgical JJ cord-023095-4dannjjm 4737 2 repair repair NN cord-023095-4dannjjm 4737 3 is be VBZ cord-023095-4dannjjm 4737 4 part part NN cord-023095-4dannjjm 4737 5 of of IN cord-023095-4dannjjm 4737 6 the the DT cord-023095-4dannjjm 4737 7 emergency emergency NN cord-023095-4dannjjm 4737 8 treatment treatment NN cord-023095-4dannjjm 4737 9 described describe VBN cord-023095-4dannjjm 4737 10 for for IN cord-023095-4dannjjm 4737 11 this this DT cord-023095-4dannjjm 4737 12 disorder disorder NN cord-023095-4dannjjm 4737 13 but but CC cord-023095-4dannjjm 4737 14 does do VBZ cord-023095-4dannjjm 4737 15 not not RB cord-023095-4dannjjm 4737 16 guarantee guarantee VB cord-023095-4dannjjm 4737 17 improvement improvement NN cord-023095-4dannjjm 4737 18 of of IN cord-023095-4dannjjm 4737 19 the the DT cord-023095-4dannjjm 4737 20 associated associate VBN cord-023095-4dannjjm 4737 21 clinical clinical JJ cord-023095-4dannjjm 4737 22 signs sign NNS cord-023095-4dannjjm 4737 23 . . . cord-023095-4dannjjm 4738 1 Multiple multiple JJ cord-023095-4dannjjm 4738 2 surgical surgical JJ cord-023095-4dannjjm 4738 3 repair repair NN cord-023095-4dannjjm 4738 4 techniques technique NNS cord-023095-4dannjjm 4738 5 have have VBP cord-023095-4dannjjm 4738 6 been be VBN cord-023095-4dannjjm 4738 7 described describe VBN cord-023095-4dannjjm 4738 8 but but CC cord-023095-4dannjjm 4738 9 have have VBP cord-023095-4dannjjm 4738 10 not not RB cord-023095-4dannjjm 4738 11 been be VBN cord-023095-4dannjjm 4738 12 compared compare VBN cord-023095-4dannjjm 4738 13 in in IN cord-023095-4dannjjm 4738 14 terms term NNS cord-023095-4dannjjm 4738 15 of of IN cord-023095-4dannjjm 4738 16 their -PRON- PRP$ cord-023095-4dannjjm 4738 17 success success NN cord-023095-4dannjjm 4738 18 and and CC cord-023095-4dannjjm 4738 19 the the DT cord-023095-4dannjjm 4738 20 factors factor NNS cord-023095-4dannjjm 4738 21 associated associate VBN cord-023095-4dannjjm 4738 22 with with IN cord-023095-4dannjjm 4738 23 a a DT cord-023095-4dannjjm 4738 24 positive positive JJ cord-023095-4dannjjm 4738 25 outcome outcome NN cord-023095-4dannjjm 4738 26 . . . cord-023095-4dannjjm 4739 1 The the DT cord-023095-4dannjjm 4739 2 aims aim NNS cord-023095-4dannjjm 4739 3 of of IN cord-023095-4dannjjm 4739 4 this this DT cord-023095-4dannjjm 4739 5 study study NN cord-023095-4dannjjm 4739 6 were be VBD cord-023095-4dannjjm 4739 7 to to TO cord-023095-4dannjjm 4739 8 retrospectively retrospectively RB cord-023095-4dannjjm 4739 9 evaluate evaluate VB cord-023095-4dannjjm 4739 10 the the DT cord-023095-4dannjjm 4739 11 effect effect NN cord-023095-4dannjjm 4739 12 of of IN cord-023095-4dannjjm 4739 13 3 3 CD cord-023095-4dannjjm 4739 14 different different JJ cord-023095-4dannjjm 4739 15 types type NNS cord-023095-4dannjjm 4739 16 of of IN cord-023095-4dannjjm 4739 17 vertebral vertebral JJ cord-023095-4dannjjm 4739 18 repair repair NN cord-023095-4dannjjm 4739 19 , , , cord-023095-4dannjjm 4739 20 injury injury NN cord-023095-4dannjjm 4739 21 type type NN cord-023095-4dannjjm 4739 22 and and CC cord-023095-4dannjjm 4739 23 injury injury NN cord-023095-4dannjjm 4739 24 location location NN cord-023095-4dannjjm 4739 25 on on IN cord-023095-4dannjjm 4739 26 outcome outcome NN cord-023095-4dannjjm 4739 27 in in IN cord-023095-4dannjjm 4739 28 dogs dog NNS cord-023095-4dannjjm 4739 29 with with IN cord-023095-4dannjjm 4739 30 thoracolumbar thoracolumbar NN cord-023095-4dannjjm 4739 31 ( ( -LRB- cord-023095-4dannjjm 4739 32 TL TL NNP cord-023095-4dannjjm 4739 33 ) ) -RRB- cord-023095-4dannjjm 4739 34 and and CC cord-023095-4dannjjm 4739 35 lumbosacral lumbosacral NNP cord-023095-4dannjjm 4739 36 ( ( -LRB- cord-023095-4dannjjm 4739 37 LS LS NNP cord-023095-4dannjjm 4739 38 ) ) -RRB- cord-023095-4dannjjm 4739 39 spinal spinal JJ cord-023095-4dannjjm 4739 40 trauma trauma NN cord-023095-4dannjjm 4739 41 . . . cord-023095-4dannjjm 4740 1 Medical medical JJ cord-023095-4dannjjm 4740 2 records record NNS cord-023095-4dannjjm 4740 3 were be VBD cord-023095-4dannjjm 4740 4 searched search VBN cord-023095-4dannjjm 4740 5 for for IN cord-023095-4dannjjm 4740 6 dogs dog NNS cord-023095-4dannjjm 4740 7 with with IN cord-023095-4dannjjm 4740 8 radiographic radiographic JJ cord-023095-4dannjjm 4740 9 evidence evidence NN cord-023095-4dannjjm 4740 10 of of IN cord-023095-4dannjjm 4740 11 a a DT cord-023095-4dannjjm 4740 12 TL TL NNP cord-023095-4dannjjm 4740 13 or or CC cord-023095-4dannjjm 4740 14 LS ls NN cord-023095-4dannjjm 4740 15 vertebral vertebral JJ cord-023095-4dannjjm 4740 16 fracture fracture NN cord-023095-4dannjjm 4740 17 and and CC cord-023095-4dannjjm 4740 18 or or CC cord-023095-4dannjjm 4740 19 luxation luxation NN cord-023095-4dannjjm 4740 20 ( ( -LRB- cord-023095-4dannjjm 4740 21 1995 1995 CD cord-023095-4dannjjm 4740 22 ) ) -RRB- cord-023095-4dannjjm 4741 1 ( ( -LRB- cord-023095-4dannjjm 4741 2 1996 1996 CD cord-023095-4dannjjm 4741 3 ) ) -RRB- cord-023095-4dannjjm 4742 1 ( ( -LRB- cord-023095-4dannjjm 4742 2 1997 1997 CD cord-023095-4dannjjm 4742 3 ) ) -RRB- cord-023095-4dannjjm 4743 1 ( ( -LRB- cord-023095-4dannjjm 4743 2 1998 1998 CD cord-023095-4dannjjm 4743 3 ) ) -RRB- cord-023095-4dannjjm 4744 1 ( ( -LRB- cord-023095-4dannjjm 4744 2 1999 1999 CD cord-023095-4dannjjm 4744 3 ) ) -RRB- cord-023095-4dannjjm 4745 1 ( ( -LRB- cord-023095-4dannjjm 4745 2 2000 2000 CD cord-023095-4dannjjm 4745 3 ) ) -RRB- cord-023095-4dannjjm 4746 1 ( ( -LRB- cord-023095-4dannjjm 4746 2 2001 2001 CD cord-023095-4dannjjm 4746 3 ) ) -RRB- cord-023095-4dannjjm 4746 4 ( ( -LRB- cord-023095-4dannjjm 4746 5 2002 2002 CD cord-023095-4dannjjm 4746 6 ) ) -RRB- cord-023095-4dannjjm 4747 1 ( ( -LRB- cord-023095-4dannjjm 4747 2 2003 2003 CD cord-023095-4dannjjm 4747 3 ) ) -RRB- cord-023095-4dannjjm 4748 1 ( ( -LRB- cord-023095-4dannjjm 4748 2 2004 2004 CD cord-023095-4dannjjm 4748 3 ) ) -RRB- cord-023095-4dannjjm 4749 1 ( ( -LRB- cord-023095-4dannjjm 4749 2 2005 2005 CD cord-023095-4dannjjm 4749 3 ) ) -RRB- cord-023095-4dannjjm 4750 1 ( ( -LRB- cord-023095-4dannjjm 4750 2 2006 2006 CD cord-023095-4dannjjm 4750 3 ) ) -RRB- cord-023095-4dannjjm 4751 1 ( ( -LRB- cord-023095-4dannjjm 4751 2 2007 2007 CD cord-023095-4dannjjm 4751 3 ) ) -RRB- cord-023095-4dannjjm 4752 1 ( ( -LRB- cord-023095-4dannjjm 4752 2 2008 2008 CD cord-023095-4dannjjm 4752 3 ) ) -RRB- cord-023095-4dannjjm 4753 1 ( ( -LRB- cord-023095-4dannjjm 4753 2 2009 2009 CD cord-023095-4dannjjm 4753 3 ) ) -RRB- cord-023095-4dannjjm 4754 1 ( ( -LRB- cord-023095-4dannjjm 4754 2 2010 2010 CD cord-023095-4dannjjm 4754 3 ) ) -RRB- cord-023095-4dannjjm 4754 4 ; ; : cord-023095-4dannjjm 4754 5 signalment signalment JJ cord-023095-4dannjjm 4754 6 , , , cord-023095-4dannjjm 4754 7 body body NN cord-023095-4dannjjm 4754 8 weight weight NN cord-023095-4dannjjm 4754 9 and and CC cord-023095-4dannjjm 4754 10 duration duration NN cord-023095-4dannjjm 4754 11 of of IN cord-023095-4dannjjm 4754 12 disease disease NN cord-023095-4dannjjm 4754 13 were be VBD cord-023095-4dannjjm 4754 14 recorded record VBN cord-023095-4dannjjm 4754 15 . . . cord-023095-4dannjjm 4755 1 Dogs dog NNS cord-023095-4dannjjm 4755 2 were be VBD cord-023095-4dannjjm 4755 3 retrospectively retrospectively RB cord-023095-4dannjjm 4755 4 scored score VBN cord-023095-4dannjjm 4755 5 neurologically neurologically RB cord-023095-4dannjjm 4755 6 ( ( -LRB- cord-023095-4dannjjm 4755 7 0 0 CD cord-023095-4dannjjm 4755 8 - - SYM cord-023095-4dannjjm 4755 9 5 5 CD cord-023095-4dannjjm 4755 10 ; ; , cord-023095-4dannjjm 4755 11 normal normal JJ cord-023095-4dannjjm 4755 12 to to IN cord-023095-4dannjjm 4755 13 plegic plegic VB cord-023095-4dannjjm 4755 14 with with IN cord-023095-4dannjjm 4755 15 absent absent JJ cord-023095-4dannjjm 4755 16 pain pain NN cord-023095-4dannjjm 4755 17 perception perception NN cord-023095-4dannjjm 4755 18 ) ) -RRB- cord-023095-4dannjjm 4755 19 on on IN cord-023095-4dannjjm 4755 20 admission admission NN cord-023095-4dannjjm 4755 21 and and CC cord-023095-4dannjjm 4755 22 at at IN cord-023095-4dannjjm 4755 23 re re NN cord-023095-4dannjjm 4755 24 - - NN cord-023095-4dannjjm 4755 25 evaluation evaluation JJ cord-023095-4dannjjm 4755 26 following follow VBG cord-023095-4dannjjm 4755 27 surgery surgery NN cord-023095-4dannjjm 4755 28 . . . cord-023095-4dannjjm 4756 1 Lesion lesion NN cord-023095-4dannjjm 4756 2 location location NN cord-023095-4dannjjm 4756 3 was be VBD cord-023095-4dannjjm 4756 4 classed class VBN cord-023095-4dannjjm 4756 5 as as IN cord-023095-4dannjjm 4756 6 T3-L3 T3-L3 NNP cord-023095-4dannjjm 4756 7 and and CC cord-023095-4dannjjm 4756 8 L4-S3 L4-S3 NNP cord-023095-4dannjjm 4756 9 ; ; : cord-023095-4dannjjm 4756 10 dogs dog NNS cord-023095-4dannjjm 4756 11 were be VBD cord-023095-4dannjjm 4756 12 evaluated evaluate VBN cord-023095-4dannjjm 4756 13 as as IN cord-023095-4dannjjm 4756 14 one one CD cord-023095-4dannjjm 4756 15 group group NN cord-023095-4dannjjm 4756 16 and and CC cord-023095-4dannjjm 4756 17 as as IN cord-023095-4dannjjm 4756 18 two two CD cord-023095-4dannjjm 4756 19 separate separate JJ cord-023095-4dannjjm 4756 20 groups group NNS cord-023095-4dannjjm 4756 21 with with IN cord-023095-4dannjjm 4756 22 respect respect NN cord-023095-4dannjjm 4756 23 to to IN cord-023095-4dannjjm 4756 24 outcome outcome NN cord-023095-4dannjjm 4756 25 . . . cord-023095-4dannjjm 4757 1 A a DT cord-023095-4dannjjm 4757 2 subset subset NN cord-023095-4dannjjm 4757 3 of of IN cord-023095-4dannjjm 4757 4 lesions lesion NNS cord-023095-4dannjjm 4757 5 were be VBD cord-023095-4dannjjm 4757 6 classed class VBN cord-023095-4dannjjm 4757 7 as as IN cord-023095-4dannjjm 4757 8 cord cord NN cord-023095-4dannjjm 4757 9 compression compression NN cord-023095-4dannjjm 4757 10 or or CC cord-023095-4dannjjm 4757 11 not not RB cord-023095-4dannjjm 4757 12 based base VBN cord-023095-4dannjjm 4757 13 on on IN cord-023095-4dannjjm 4757 14 advanced advanced JJ cord-023095-4dannjjm 4757 15 imaging imaging NN cord-023095-4dannjjm 4757 16 . . . cord-023095-4dannjjm 4758 1 Three three CD cord-023095-4dannjjm 4758 2 repair repair NN cord-023095-4dannjjm 4758 3 techniques technique NNS cord-023095-4dannjjm 4758 4 were be VBD cord-023095-4dannjjm 4758 5 evaluated evaluate VBN cord-023095-4dannjjm 4758 6 ( ( -LRB- cord-023095-4dannjjm 4758 7 i i NN cord-023095-4dannjjm 4758 8 ) ) -RRB- cord-023095-4dannjjm 4758 9 pins pin NNS cord-023095-4dannjjm 4758 10 and and CC cord-023095-4dannjjm 4758 11 polymethylmethacrylate polymethylmethacrylate NNP cord-023095-4dannjjm 4758 12 ( ( -LRB- cord-023095-4dannjjm 4758 13 PMMA PMMA NNP cord-023095-4dannjjm 4758 14 ) ) -RRB- cord-023095-4dannjjm 4758 15 ; ; : cord-023095-4dannjjm 4758 16 ( ( -LRB- cord-023095-4dannjjm 4758 17 ii ii NN cord-023095-4dannjjm 4758 18 ) ) -RRB- cord-023095-4dannjjm 4758 19 screws screw NNS cord-023095-4dannjjm 4758 20 and and CC cord-023095-4dannjjm 4758 21 PMMA PMMA NNP cord-023095-4dannjjm 4758 22 ; ; : cord-023095-4dannjjm 4758 23 and and CC cord-023095-4dannjjm 4758 24 ( ( -LRB- cord-023095-4dannjjm 4758 25 iii iii NN cord-023095-4dannjjm 4758 26 ) ) -RRB- cord-023095-4dannjjm 4758 27 spinal spinal JJ cord-023095-4dannjjm 4758 28 stapling stapling NN cord-023095-4dannjjm 4758 29 . . . cord-023095-4dannjjm 4759 1 Regression regression NN cord-023095-4dannjjm 4759 2 analysis analysis NN cord-023095-4dannjjm 4759 3 was be VBD cord-023095-4dannjjm 4759 4 applied apply VBN cord-023095-4dannjjm 4759 5 to to TO cord-023095-4dannjjm 4759 6 test test VB cord-023095-4dannjjm 4759 7 for for IN cord-023095-4dannjjm 4759 8 an an DT cord-023095-4dannjjm 4759 9 association association NN cord-023095-4dannjjm 4759 10 between between IN cord-023095-4dannjjm 4759 11 the the DT cord-023095-4dannjjm 4759 12 type type NN cord-023095-4dannjjm 4759 13 of of IN cord-023095-4dannjjm 4759 14 surgery surgery NN cord-023095-4dannjjm 4759 15 and and CC cord-023095-4dannjjm 4759 16 a a DT cord-023095-4dannjjm 4759 17 successful successful JJ cord-023095-4dannjjm 4759 18 outcome outcome NN cord-023095-4dannjjm 4759 19 ( ( -LRB- cord-023095-4dannjjm 4759 20 non non JJ cord-023095-4dannjjm 4759 21 - - JJ cord-023095-4dannjjm 4759 22 painful painful JJ cord-023095-4dannjjm 4759 23 and and CC cord-023095-4dannjjm 4759 24 ambulatory ambulatory JJ cord-023095-4dannjjm 4759 25 ) ) -RRB- cord-023095-4dannjjm 4759 26 . . . cord-023095-4dannjjm 4760 1 Simple simple JJ cord-023095-4dannjjm 4760 2 bivariate bivariate JJ cord-023095-4dannjjm 4760 3 analyses analysis NNS cord-023095-4dannjjm 4760 4 were be VBD cord-023095-4dannjjm 4760 5 performed perform VBN cord-023095-4dannjjm 4760 6 to to TO cord-023095-4dannjjm 4760 7 investigate investigate VB cord-023095-4dannjjm 4760 8 for for IN cord-023095-4dannjjm 4760 9 variables variable NNS cord-023095-4dannjjm 4760 10 predictive predictive JJ cord-023095-4dannjjm 4760 11 of of IN cord-023095-4dannjjm 4760 12 a a DT cord-023095-4dannjjm 4760 13 successful successful JJ cord-023095-4dannjjm 4760 14 outcome outcome NN cord-023095-4dannjjm 4760 15 . . . cord-023095-4dannjjm 4761 1 Fifty fifty CD cord-023095-4dannjjm 4761 2 - - HYPH cord-023095-4dannjjm 4761 3 nine nine CD cord-023095-4dannjjm 4761 4 dogs dog NNS cord-023095-4dannjjm 4761 5 were be VBD cord-023095-4dannjjm 4761 6 included include VBN cord-023095-4dannjjm 4761 7 . . . cord-023095-4dannjjm 4762 1 Twenty twenty CD cord-023095-4dannjjm 4762 2 - - HYPH cord-023095-4dannjjm 4762 3 eight eight CD cord-023095-4dannjjm 4762 4 dogs dog NNS cord-023095-4dannjjm 4762 5 were be VBD cord-023095-4dannjjm 4762 6 classed class VBN cord-023095-4dannjjm 4762 7 as as IN cord-023095-4dannjjm 4762 8 T3-L3 T3-L3 NNP cord-023095-4dannjjm 4762 9 and and CC cord-023095-4dannjjm 4762 10 31 31 CD cord-023095-4dannjjm 4762 11 were be VBD cord-023095-4dannjjm 4762 12 L4-S3 L4-S3 NNP cord-023095-4dannjjm 4762 13 . . . cord-023095-4dannjjm 4763 1 There there EX cord-023095-4dannjjm 4763 2 were be VBD cord-023095-4dannjjm 4763 3 55 55 CD cord-023095-4dannjjm 4763 4 dogs dog NNS cord-023095-4dannjjm 4763 5 with with IN cord-023095-4dannjjm 4763 6 fractures fracture NNS cord-023095-4dannjjm 4763 7 and and CC cord-023095-4dannjjm 4763 8 43 43 CD cord-023095-4dannjjm 4763 9 with with IN cord-023095-4dannjjm 4763 10 luxations luxation NNS cord-023095-4dannjjm 4763 11 ; ; : cord-023095-4dannjjm 4763 12 23 23 CD cord-023095-4dannjjm 4763 13 dogs dog NNS cord-023095-4dannjjm 4763 14 had have VBD cord-023095-4dannjjm 4763 15 both both DT cord-023095-4dannjjm 4763 16 . . . cord-023095-4dannjjm 4764 1 Thirty thirty CD cord-023095-4dannjjm 4764 2 - - HYPH cord-023095-4dannjjm 4764 3 one one CD cord-023095-4dannjjm 4764 4 of of IN cord-023095-4dannjjm 4764 5 35 35 CD cord-023095-4dannjjm 4764 6 dogs dog NNS cord-023095-4dannjjm 4764 7 evaluated evaluate VBN cord-023095-4dannjjm 4764 8 had have VBD cord-023095-4dannjjm 4764 9 spinal spinal JJ cord-023095-4dannjjm 4764 10 cord cord NN cord-023095-4dannjjm 4764 11 compression compression NN cord-023095-4dannjjm 4764 12 . . . cord-023095-4dannjjm 4765 1 Ten ten CD cord-023095-4dannjjm 4765 2 dogs dog NNS cord-023095-4dannjjm 4765 3 were be VBD cord-023095-4dannjjm 4765 4 repaired repair VBN cord-023095-4dannjjm 4765 5 with with IN cord-023095-4dannjjm 4765 6 IM im JJ cord-023095-4dannjjm 4765 7 pins pin NNS cord-023095-4dannjjm 4765 8 and and CC cord-023095-4dannjjm 4765 9 PMMA PMMA NNP cord-023095-4dannjjm 4765 10 , , , cord-023095-4dannjjm 4765 11 18 18 CD cord-023095-4dannjjm 4765 12 dogs dog NNS cord-023095-4dannjjm 4765 13 with with IN cord-023095-4dannjjm 4765 14 screws screw NNS cord-023095-4dannjjm 4765 15 and and CC cord-023095-4dannjjm 4765 16 PMMA PMMA NNP cord-023095-4dannjjm 4765 17 and and CC cord-023095-4dannjjm 4765 18 31 31 CD cord-023095-4dannjjm 4765 19 dogs dog NNS cord-023095-4dannjjm 4765 20 with with IN cord-023095-4dannjjm 4765 21 spinal spinal JJ cord-023095-4dannjjm 4765 22 stapling stapling NN cord-023095-4dannjjm 4765 23 . . . cord-023095-4dannjjm 4766 1 Overall overall RB cord-023095-4dannjjm 4766 2 , , , cord-023095-4dannjjm 4766 3 there there EX cord-023095-4dannjjm 4766 4 was be VBD cord-023095-4dannjjm 4766 5 a a DT cord-023095-4dannjjm 4766 6 78.7 78.7 CD cord-023095-4dannjjm 4766 7 % % NN cord-023095-4dannjjm 4766 8 success success NN cord-023095-4dannjjm 4766 9 rate rate NN cord-023095-4dannjjm 4766 10 ; ; : cord-023095-4dannjjm 4766 11 there there EX cord-023095-4dannjjm 4766 12 was be VBD cord-023095-4dannjjm 4766 13 no no DT cord-023095-4dannjjm 4766 14 significant significant JJ cord-023095-4dannjjm 4766 15 difference difference NN cord-023095-4dannjjm 4766 16 in in IN cord-023095-4dannjjm 4766 17 outcome outcome NN cord-023095-4dannjjm 4766 18 between between IN cord-023095-4dannjjm 4766 19 the the DT cord-023095-4dannjjm 4766 20 anatomic anatomic JJ cord-023095-4dannjjm 4766 21 sites site NNS cord-023095-4dannjjm 4766 22 ( ( -LRB- cord-023095-4dannjjm 4766 23 p p NN cord-023095-4dannjjm 4766 24 5 5 CD cord-023095-4dannjjm 4766 25 0.5 0.5 CD cord-023095-4dannjjm 4766 26 ) ) -RRB- cord-023095-4dannjjm 4766 27 . . . cord-023095-4dannjjm 4767 1 All all DT cord-023095-4dannjjm 4767 2 dogs dog NNS cord-023095-4dannjjm 4767 3 initially initially RB cord-023095-4dannjjm 4767 4 graded grade VBD cord-023095-4dannjjm 4767 5 as as IN cord-023095-4dannjjm 4767 6 1 1 CD cord-023095-4dannjjm 4767 7 - - SYM cord-023095-4dannjjm 4767 8 3 3 CD cord-023095-4dannjjm 4767 9 pre pre NN cord-023095-4dannjjm 4767 10 - - NN cord-023095-4dannjjm 4767 11 operation operation NN cord-023095-4dannjjm 4767 12 were be VBD cord-023095-4dannjjm 4767 13 classed class VBN cord-023095-4dannjjm 4767 14 as as IN cord-023095-4dannjjm 4767 15 a a DT cord-023095-4dannjjm 4767 16 successful successful JJ cord-023095-4dannjjm 4767 17 outcome outcome NN cord-023095-4dannjjm 4767 18 after after IN cord-023095-4dannjjm 4767 19 at at RB cord-023095-4dannjjm 4767 20 least least RBS cord-023095-4dannjjm 4767 21 one one CD cord-023095-4dannjjm 4767 22 week week NN cord-023095-4dannjjm 4767 23 following follow VBG cord-023095-4dannjjm 4767 24 surgery surgery NN cord-023095-4dannjjm 4767 25 ; ; : cord-023095-4dannjjm 4767 26 79 79 CD cord-023095-4dannjjm 4767 27 % % NN cord-023095-4dannjjm 4767 28 of of IN cord-023095-4dannjjm 4767 29 dogs dog NNS cord-023095-4dannjjm 4767 30 initially initially RB cord-023095-4dannjjm 4767 31 graded grade VBD cord-023095-4dannjjm 4767 32 as as IN cord-023095-4dannjjm 4767 33 4 4 CD cord-023095-4dannjjm 4767 34 ( ( -LRB- cord-023095-4dannjjm 4767 35 plegic plegic NNP cord-023095-4dannjjm 4767 36 with with IN cord-023095-4dannjjm 4767 37 pain pain NN cord-023095-4dannjjm 4767 38 perception perception NN cord-023095-4dannjjm 4767 39 ) ) -RRB- cord-023095-4dannjjm 4767 40 were be VBD cord-023095-4dannjjm 4767 41 classed class VBN cord-023095-4dannjjm 4767 42 as as IN cord-023095-4dannjjm 4767 43 successful successful JJ cord-023095-4dannjjm 4767 44 recovery recovery NN cord-023095-4dannjjm 4767 45 . . . cord-023095-4dannjjm 4768 1 One one CD cord-023095-4dannjjm 4768 2 dog dog NN cord-023095-4dannjjm 4768 3 ( ( -LRB- cord-023095-4dannjjm 4768 4 12.5 12.5 CD cord-023095-4dannjjm 4768 5 % % NN cord-023095-4dannjjm 4768 6 ) ) -RRB- cord-023095-4dannjjm 4768 7 initially initially RB cord-023095-4dannjjm 4768 8 as as RB cord-023095-4dannjjm 4768 9 graded grade VBN cord-023095-4dannjjm 4768 10 as as IN cord-023095-4dannjjm 4768 11 5 5 CD cord-023095-4dannjjm 4768 12 ( ( -LRB- cord-023095-4dannjjm 4768 13 plegic plegic NNP cord-023095-4dannjjm 4768 14 with with IN cord-023095-4dannjjm 4768 15 no no DT cord-023095-4dannjjm 4768 16 pain pain NN cord-023095-4dannjjm 4768 17 perception perception NN cord-023095-4dannjjm 4768 18 ) ) -RRB- cord-023095-4dannjjm 4768 19 had have VBD cord-023095-4dannjjm 4768 20 a a DT cord-023095-4dannjjm 4768 21 successful successful JJ cord-023095-4dannjjm 4768 22 outcome outcome NN cord-023095-4dannjjm 4768 23 . . . cord-023095-4dannjjm 4769 1 A a DT cord-023095-4dannjjm 4769 2 low low JJ cord-023095-4dannjjm 4769 3 admission admission NN cord-023095-4dannjjm 4769 4 score score NN cord-023095-4dannjjm 4769 5 was be VBD cord-023095-4dannjjm 4769 6 statistically statistically RB cord-023095-4dannjjm 4769 7 predictive predictive JJ cord-023095-4dannjjm 4769 8 of of IN cord-023095-4dannjjm 4769 9 a a DT cord-023095-4dannjjm 4769 10 successful successful JJ cord-023095-4dannjjm 4769 11 outcome outcome NN cord-023095-4dannjjm 4769 12 ( ( -LRB- cord-023095-4dannjjm 4769 13 p p NN cord-023095-4dannjjm 4769 14 o o NN cord-023095-4dannjjm 4769 15 0.0001 0.0001 CD cord-023095-4dannjjm 4769 16 ) ) -RRB- cord-023095-4dannjjm 4769 17 . . . cord-023095-4dannjjm 4770 1 Surgery surgery NN cord-023095-4dannjjm 4770 2 type type NN cord-023095-4dannjjm 4770 3 was be VBD cord-023095-4dannjjm 4770 4 not not RB cord-023095-4dannjjm 4770 5 associated associate VBN cord-023095-4dannjjm 4770 6 with with IN cord-023095-4dannjjm 4770 7 a a DT cord-023095-4dannjjm 4770 8 successful successful JJ cord-023095-4dannjjm 4770 9 recovery recovery NN cord-023095-4dannjjm 4770 10 ( ( -LRB- cord-023095-4dannjjm 4770 11 p p NN cord-023095-4dannjjm 4770 12 5 5 CD cord-023095-4dannjjm 4770 13 0.13 0.13 CD cord-023095-4dannjjm 4770 14 ) ) -RRB- cord-023095-4dannjjm 4770 15 . . . cord-023095-4dannjjm 4771 1 Signalment signalment JJ cord-023095-4dannjjm 4771 2 , , , cord-023095-4dannjjm 4771 3 body body NN cord-023095-4dannjjm 4771 4 weight weight NN cord-023095-4dannjjm 4771 5 , , , cord-023095-4dannjjm 4771 6 location location NN cord-023095-4dannjjm 4771 7 of of IN cord-023095-4dannjjm 4771 8 injury injury NN cord-023095-4dannjjm 4771 9 , , , cord-023095-4dannjjm 4771 10 injury injury NN cord-023095-4dannjjm 4771 11 type type NN cord-023095-4dannjjm 4771 12 ( ( -LRB- cord-023095-4dannjjm 4771 13 fracture fracture NN cord-023095-4dannjjm 4771 14 , , , cord-023095-4dannjjm 4771 15 luxation luxation NN cord-023095-4dannjjm 4771 16 or or CC cord-023095-4dannjjm 4771 17 both both DT cord-023095-4dannjjm 4771 18 ) ) -RRB- cord-023095-4dannjjm 4771 19 , , , cord-023095-4dannjjm 4771 20 presence presence NN cord-023095-4dannjjm 4771 21 of of IN cord-023095-4dannjjm 4771 22 compression compression NN cord-023095-4dannjjm 4771 23 , , , cord-023095-4dannjjm 4771 24 and and CC cord-023095-4dannjjm 4771 25 duration duration NN cord-023095-4dannjjm 4771 26 of of IN cord-023095-4dannjjm 4771 27 disease disease NN cord-023095-4dannjjm 4771 28 did do VBD cord-023095-4dannjjm 4771 29 not not RB cord-023095-4dannjjm 4771 30 predict predict VB cord-023095-4dannjjm 4771 31 outcome outcome NN cord-023095-4dannjjm 4771 32 . . . cord-023095-4dannjjm 4772 1 From from IN cord-023095-4dannjjm 4772 2 this this DT cord-023095-4dannjjm 4772 3 study study NN cord-023095-4dannjjm 4772 4 , , , cord-023095-4dannjjm 4772 5 the the DT cord-023095-4dannjjm 4772 6 successful successful JJ cord-023095-4dannjjm 4772 7 recovery recovery NN cord-023095-4dannjjm 4772 8 of of IN cord-023095-4dannjjm 4772 9 dogs dog NNS cord-023095-4dannjjm 4772 10 following follow VBG cord-023095-4dannjjm 4772 11 surgical surgical JJ cord-023095-4dannjjm 4772 12 fixation fixation NN cord-023095-4dannjjm 4772 13 is be VBZ cord-023095-4dannjjm 4772 14 high high JJ cord-023095-4dannjjm 4772 15 and and CC cord-023095-4dannjjm 4772 16 is be VBZ cord-023095-4dannjjm 4772 17 only only RB cord-023095-4dannjjm 4772 18 dependent dependent JJ cord-023095-4dannjjm 4772 19 on on IN cord-023095-4dannjjm 4772 20 the the DT cord-023095-4dannjjm 4772 21 neurological neurological JJ cord-023095-4dannjjm 4772 22 score score NN cord-023095-4dannjjm 4772 23 at at IN cord-023095-4dannjjm 4772 24 the the DT cord-023095-4dannjjm 4772 25 time time NN cord-023095-4dannjjm 4772 26 of of IN cord-023095-4dannjjm 4772 27 admission admission NN cord-023095-4dannjjm 4772 28 . . . cord-023095-4dannjjm 4773 1 The the DT cord-023095-4dannjjm 4773 2 choice choice NN cord-023095-4dannjjm 4773 3 of of IN cord-023095-4dannjjm 4773 4 surgical surgical JJ cord-023095-4dannjjm 4773 5 technique technique NN cord-023095-4dannjjm 4773 6 does do VBZ cord-023095-4dannjjm 4773 7 not not RB cord-023095-4dannjjm 4773 8 seem seem VB cord-023095-4dannjjm 4773 9 to to TO cord-023095-4dannjjm 4773 10 influence influence VB cord-023095-4dannjjm 4773 11 outcome outcome NN cord-023095-4dannjjm 4773 12 although although IN cord-023095-4dannjjm 4773 13 a a DT cord-023095-4dannjjm 4773 14 prospective prospective JJ cord-023095-4dannjjm 4773 15 study study NN cord-023095-4dannjjm 4773 16 comparing compare VBG cord-023095-4dannjjm 4773 17 two two CD cord-023095-4dannjjm 4773 18 surgery surgery NN cord-023095-4dannjjm 4773 19 types type NNS cord-023095-4dannjjm 4773 20 is be VBZ cord-023095-4dannjjm 4773 21 warranted warrant VBN cord-023095-4dannjjm 4773 22 to to TO cord-023095-4dannjjm 4773 23 further further RB cord-023095-4dannjjm 4773 24 investigate investigate VB cord-023095-4dannjjm 4773 25 this this DT cord-023095-4dannjjm 4773 26 issue issue NN cord-023095-4dannjjm 4773 27 the the DT cord-023095-4dannjjm 4773 28 results result NNS cord-023095-4dannjjm 4773 29 of of IN cord-023095-4dannjjm 4773 30 which which WDT cord-023095-4dannjjm 4773 31 can can MD cord-023095-4dannjjm 4773 32 be be VB cord-023095-4dannjjm 4773 33 confounded confound VBN cord-023095-4dannjjm 4773 34 by by IN cord-023095-4dannjjm 4773 35 surgeon surgeon NN cord-023095-4dannjjm 4773 36 experience experience NN cord-023095-4dannjjm 4773 37 and and CC cord-023095-4dannjjm 4773 38 variable variable JJ cord-023095-4dannjjm 4773 39 follow follow NN cord-023095-4dannjjm 4773 40 - - HYPH cord-023095-4dannjjm 4773 41 up up NN cord-023095-4dannjjm 4773 42 . . . cord-023095-4dannjjm 4774 1 Cranial cranial JJ cord-023095-4dannjjm 4774 2 thoracic thoracic JJ cord-023095-4dannjjm 4774 3 intervertebral intervertebral JJ cord-023095-4dannjjm 4774 4 disc disc NN cord-023095-4dannjjm 4774 5 disease disease NN cord-023095-4dannjjm 4774 6 ( ( -LRB- cord-023095-4dannjjm 4774 7 IVDD IVDD NNP cord-023095-4dannjjm 4774 8 ) ) -RRB- cord-023095-4dannjjm 4774 9 is be VBZ cord-023095-4dannjjm 4774 10 extremely extremely RB cord-023095-4dannjjm 4774 11 rare rare JJ cord-023095-4dannjjm 4774 12 due due IN cord-023095-4dannjjm 4774 13 to to IN cord-023095-4dannjjm 4774 14 the the DT cord-023095-4dannjjm 4774 15 presence presence NN cord-023095-4dannjjm 4774 16 of of IN cord-023095-4dannjjm 4774 17 the the DT cord-023095-4dannjjm 4774 18 intercapital intercapital NNP cord-023095-4dannjjm 4774 19 ligament ligament NN cord-023095-4dannjjm 4774 20 , , , cord-023095-4dannjjm 4774 21 although although IN cord-023095-4dannjjm 4774 22 anecdotic anecdotic JJ cord-023095-4dannjjm 4774 23 data datum NNS cord-023095-4dannjjm 4774 24 suggest suggest VBP cord-023095-4dannjjm 4774 25 German german JJ cord-023095-4dannjjm 4774 26 shepherd shepherd NN cord-023095-4dannjjm 4774 27 dogs dog NNS cord-023095-4dannjjm 4774 28 ( ( -LRB- cord-023095-4dannjjm 4774 29 GSD GSD NNP cord-023095-4dannjjm 4774 30 ) ) -RRB- cord-023095-4dannjjm 4774 31 can can MD cord-023095-4dannjjm 4774 32 share share VB cord-023095-4dannjjm 4774 33 some some DT cord-023095-4dannjjm 4774 34 predisposition predisposition NN cord-023095-4dannjjm 4774 35 for for IN cord-023095-4dannjjm 4774 36 this this DT cord-023095-4dannjjm 4774 37 disorder disorder NN cord-023095-4dannjjm 4774 38 . . . cord-023095-4dannjjm 4775 1 The the DT cord-023095-4dannjjm 4775 2 objective objective NN cord-023095-4dannjjm 4775 3 of of IN cord-023095-4dannjjm 4775 4 the the DT cord-023095-4dannjjm 4775 5 study study NN cord-023095-4dannjjm 4775 6 was be VBD cord-023095-4dannjjm 4775 7 to to TO cord-023095-4dannjjm 4775 8 retrospectively retrospectively RB cord-023095-4dannjjm 4775 9 evaluate evaluate VB cord-023095-4dannjjm 4775 10 through through IN cord-023095-4dannjjm 4775 11 MRI MRI NNP cord-023095-4dannjjm 4775 12 if if IN cord-023095-4dannjjm 4775 13 cranial cranial JJ cord-023095-4dannjjm 4775 14 thoracic thoracic JJ cord-023095-4dannjjm 4775 15 IVDD IVDD NNP cord-023095-4dannjjm 4775 16 is be VBZ cord-023095-4dannjjm 4775 17 significantly significantly RB cord-023095-4dannjjm 4775 18 more more RBR cord-023095-4dannjjm 4775 19 common common JJ cord-023095-4dannjjm 4775 20 in in IN cord-023095-4dannjjm 4775 21 GSD GSD NNP cord-023095-4dannjjm 4775 22 compare compare VB cord-023095-4dannjjm 4775 23 to to IN cord-023095-4dannjjm 4775 24 other other JJ cord-023095-4dannjjm 4775 25 large large JJ cord-023095-4dannjjm 4775 26 breed breed NN cord-023095-4dannjjm 4775 27 dogs dog NNS cord-023095-4dannjjm 4775 28 . . . cord-023095-4dannjjm 4776 1 A a DT cord-023095-4dannjjm 4776 2 search search NN cord-023095-4dannjjm 4776 3 was be VBD cord-023095-4dannjjm 4776 4 done do VBN cord-023095-4dannjjm 4776 5 through through IN cord-023095-4dannjjm 4776 6 database database NN cord-023095-4dannjjm 4776 7 of of IN cord-023095-4dannjjm 4776 8 the the DT cord-023095-4dannjjm 4776 9 Ontario Ontario NNP cord-023095-4dannjjm 4776 10 Veterinary Veterinary NNP cord-023095-4dannjjm 4776 11 College College NNP cord-023095-4dannjjm 4776 12 . . . cord-023095-4dannjjm 4777 1 Any any DT cord-023095-4dannjjm 4777 2 GSD GSD NNP cord-023095-4dannjjm 4777 3 were be VBD cord-023095-4dannjjm 4778 1 a a DT cord-023095-4dannjjm 4778 2 spinal spinal JJ cord-023095-4dannjjm 4778 3 MRI MRI NNP cord-023095-4dannjjm 4778 4 including include VBG cord-023095-4dannjjm 4778 5 T1-T10 T1-T10 NNP cord-023095-4dannjjm 4778 6 spine spine NN cord-023095-4dannjjm 4778 7 was be VBD cord-023095-4dannjjm 4778 8 performed perform VBN cord-023095-4dannjjm 4778 9 was be VBD cord-023095-4dannjjm 4778 10 recruited recruit VBN cord-023095-4dannjjm 4778 11 . . . cord-023095-4dannjjm 4779 1 A a DT cord-023095-4dannjjm 4779 2 group group NN cord-023095-4dannjjm 4779 3 of of IN cord-023095-4dannjjm 4779 4 large large JJ cord-023095-4dannjjm 4779 5 - - HYPH cord-023095-4dannjjm 4779 6 breed breed NN cord-023095-4dannjjm 4779 7 non non JJ cord-023095-4dannjjm 4779 8 - - JJ cord-023095-4dannjjm 4779 9 GSD GSD NNP cord-023095-4dannjjm 4779 10 was be VBD cord-023095-4dannjjm 4779 11 used use VBN cord-023095-4dannjjm 4779 12 as as IN cord-023095-4dannjjm 4779 13 a a DT cord-023095-4dannjjm 4779 14 control control NN cord-023095-4dannjjm 4779 15 . . . cord-023095-4dannjjm 4780 1 In in IN cord-023095-4dannjjm 4780 2 the the DT cord-023095-4dannjjm 4780 3 midsaggital midsaggital JJ cord-023095-4dannjjm 4780 4 T2WI T2WI NNP cord-023095-4dannjjm 4780 5 plane plane NN cord-023095-4dannjjm 4780 6 , , , cord-023095-4dannjjm 4780 7 three three CD cord-023095-4dannjjm 4780 8 variables variable NNS cord-023095-4dannjjm 4780 9 were be VBD cord-023095-4dannjjm 4780 10 assessed assess VBN cord-023095-4dannjjm 4780 11 and and CC cord-023095-4dannjjm 4780 12 graded grade VBN cord-023095-4dannjjm 4780 13 for for IN cord-023095-4dannjjm 4780 14 each each DT cord-023095-4dannjjm 4780 15 intervertebral intervertebral JJ cord-023095-4dannjjm 4780 16 disc disc NN cord-023095-4dannjjm 4780 17 space space NN cord-023095-4dannjjm 4780 18 T1-T9 T1-T9 NNP cord-023095-4dannjjm 4780 19 : : : cord-023095-4dannjjm 4780 20 spinal spinal JJ cord-023095-4dannjjm 4780 21 cord cord NN cord-023095-4dannjjm 4780 22 compression compression NN cord-023095-4dannjjm 4780 23 ( ( -LRB- cord-023095-4dannjjm 4780 24 SCC SCC NNP cord-023095-4dannjjm 4780 25 ) ) -RRB- cord-023095-4dannjjm 4780 26 , , , cord-023095-4dannjjm 4780 27 disc disc NN cord-023095-4dannjjm 4780 28 degeneration degeneration NN cord-023095-4dannjjm 4780 29 ( ( -LRB- cord-023095-4dannjjm 4780 30 DD DD NNP cord-023095-4dannjjm 4780 31 ) ) -RRB- cord-023095-4dannjjm 4780 32 , , , cord-023095-4dannjjm 4780 33 and and CC cord-023095-4dannjjm 4780 34 herniation herniation NN cord-023095-4dannjjm 4780 35 . . . cord-023095-4dannjjm 4781 1 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 4781 2 sign sign NN cord-023095-4dannjjm 4781 3 rank rank NN cord-023095-4dannjjm 4781 4 test test NN cord-023095-4dannjjm 4781 5 was be VBD cord-023095-4dannjjm 4781 6 used use VBN cord-023095-4dannjjm 4781 7 to to TO cord-023095-4dannjjm 4781 8 assess assess VB cord-023095-4dannjjm 4781 9 if if IN cord-023095-4dannjjm 4781 10 scores score NNS cord-023095-4dannjjm 4781 11 were be VBD cord-023095-4dannjjm 4781 12 different different JJ cord-023095-4dannjjm 4781 13 between between IN cord-023095-4dannjjm 4781 14 groups group NNS cord-023095-4dannjjm 4781 15 . . . cord-023095-4dannjjm 4782 1 Exact exact JJ cord-023095-4dannjjm 4782 2 conditional conditional JJ cord-023095-4dannjjm 4782 3 logistic logistic JJ cord-023095-4dannjjm 4782 4 regression regression NN cord-023095-4dannjjm 4782 5 was be VBD cord-023095-4dannjjm 4782 6 used use VBN cord-023095-4dannjjm 4782 7 to to TO cord-023095-4dannjjm 4782 8 determine determine VB cord-023095-4dannjjm 4782 9 whether whether IN cord-023095-4dannjjm 4782 10 any any DT cord-023095-4dannjjm 4782 11 intervertebral intervertebral JJ cord-023095-4dannjjm 4782 12 disc disc NN cord-023095-4dannjjm 4782 13 space space NN cord-023095-4dannjjm 4782 14 was be VBD cord-023095-4dannjjm 4782 15 a a DT cord-023095-4dannjjm 4782 16 risk risk NN cord-023095-4dannjjm 4782 17 factor factor NN cord-023095-4dannjjm 4782 18 . . . cord-023095-4dannjjm 4783 1 22 22 CD cord-023095-4dannjjm 4783 2 GSD GSD NNP cord-023095-4dannjjm 4783 3 and and CC cord-023095-4dannjjm 4783 4 46 46 CD cord-023095-4dannjjm 4783 5 large large JJ cord-023095-4dannjjm 4783 6 breed breed NN cord-023095-4dannjjm 4783 7 non non JJ cord-023095-4dannjjm 4783 8 - - JJ cord-023095-4dannjjm 4783 9 GSDs gsds NN cord-023095-4dannjjm 4783 10 were be VBD cord-023095-4dannjjm 4783 11 recruited recruit VBN cord-023095-4dannjjm 4783 12 . . . cord-023095-4dannjjm 4784 1 The the DT cord-023095-4dannjjm 4784 2 GSD GSD NNP cord-023095-4dannjjm 4784 3 group group NN cord-023095-4dannjjm 4784 4 had have VBD cord-023095-4dannjjm 4784 5 significantly significantly RB cord-023095-4dannjjm 4784 6 higher high JJR cord-023095-4dannjjm 4784 7 scores score NNS cord-023095-4dannjjm 4784 8 than than IN cord-023095-4dannjjm 4784 9 the the DT cord-023095-4dannjjm 4784 10 non non JJ cord-023095-4dannjjm 4784 11 - - JJ cord-023095-4dannjjm 4784 12 GSD GSD NNP cord-023095-4dannjjm 4784 13 for for IN cord-023095-4dannjjm 4784 14 SCC SCC NNP cord-023095-4dannjjm 4784 15 , , , cord-023095-4dannjjm 4784 16 and and CC cord-023095-4dannjjm 4784 17 herniation herniation NN cord-023095-4dannjjm 4784 18 . . . cord-023095-4dannjjm 4785 1 Regarding regard VBG cord-023095-4dannjjm 4785 2 the the DT cord-023095-4dannjjm 4785 3 individual individual JJ cord-023095-4dannjjm 4785 4 intervertebral intervertebral JJ cord-023095-4dannjjm 4785 5 discs disc NNS cord-023095-4dannjjm 4785 6 , , , cord-023095-4dannjjm 4785 7 in in IN cord-023095-4dannjjm 4785 8 the the DT cord-023095-4dannjjm 4785 9 GSD GSD NNP cord-023095-4dannjjm 4785 10 group group NN cord-023095-4dannjjm 4785 11 T2 T2 NNP cord-023095-4dannjjm 4785 12 - - HYPH cord-023095-4dannjjm 4785 13 3 3 NNP cord-023095-4dannjjm 4785 14 , , , cord-023095-4dannjjm 4785 15 T3 T3 NNP cord-023095-4dannjjm 4785 16 - - HYPH cord-023095-4dannjjm 4785 17 4 4 CD cord-023095-4dannjjm 4785 18 , , , cord-023095-4dannjjm 4785 19 T4 T4 NNP cord-023095-4dannjjm 4785 20 - - HYPH cord-023095-4dannjjm 4785 21 5 5 CD cord-023095-4dannjjm 4785 22 discs disc NNS cord-023095-4dannjjm 4785 23 had have VBD cord-023095-4dannjjm 4785 24 significantly significantly RB cord-023095-4dannjjm 4785 25 an an DT cord-023095-4dannjjm 4785 26 increased increase VBN cord-023095-4dannjjm 4785 27 risk risk NN cord-023095-4dannjjm 4785 28 for for IN cord-023095-4dannjjm 4785 29 SCC SCC NNP cord-023095-4dannjjm 4785 30 , , , cord-023095-4dannjjm 4785 31 and and CC cord-023095-4dannjjm 4785 32 T3 T3 NNP cord-023095-4dannjjm 4785 33 - - HYPH cord-023095-4dannjjm 4785 34 4 4 CD cord-023095-4dannjjm 4785 35 for for IN cord-023095-4dannjjm 4785 36 herniation herniation NN cord-023095-4dannjjm 4785 37 . . . cord-023095-4dannjjm 4786 1 The the DT cord-023095-4dannjjm 4786 2 results result NNS cord-023095-4dannjjm 4786 3 of of IN cord-023095-4dannjjm 4786 4 this this DT cord-023095-4dannjjm 4786 5 study study NN cord-023095-4dannjjm 4786 6 show show NN cord-023095-4dannjjm 4786 7 that that IN cord-023095-4dannjjm 4786 8 GSD GSD NNP cord-023095-4dannjjm 4786 9 have have VBP cord-023095-4dannjjm 4786 10 a a DT cord-023095-4dannjjm 4786 11 higher high JJR cord-023095-4dannjjm 4786 12 risk risk NN cord-023095-4dannjjm 4786 13 of of IN cord-023095-4dannjjm 4786 14 cranial cranial JJ cord-023095-4dannjjm 4786 15 thoracic thoracic JJ cord-023095-4dannjjm 4786 16 disc disc NN cord-023095-4dannjjm 4786 17 IVDD IVDD NNP cord-023095-4dannjjm 4786 18 than than IN cord-023095-4dannjjm 4786 19 other other JJ cord-023095-4dannjjm 4786 20 large large JJ cord-023095-4dannjjm 4786 21 breed breed NN cord-023095-4dannjjm 4786 22 dogs dog NNS cord-023095-4dannjjm 4786 23 . . . cord-023095-4dannjjm 4787 1 That that DT cord-023095-4dannjjm 4787 2 risk risk NN cord-023095-4dannjjm 4787 3 was be VBD cord-023095-4dannjjm 4787 4 higher high JJR cord-023095-4dannjjm 4787 5 in in IN cord-023095-4dannjjm 4787 6 discs disc NNS cord-023095-4dannjjm 4788 1 T2-T3 T2-T3 NNP cord-023095-4dannjjm 4788 2 , , , cord-023095-4dannjjm 4788 3 T3 T3 NNP cord-023095-4dannjjm 4788 4 - - HYPH cord-023095-4dannjjm 4788 5 4 4 CD cord-023095-4dannjjm 4788 6 , , , cord-023095-4dannjjm 4788 7 and and CC cord-023095-4dannjjm 4788 8 T4 T4 NNP cord-023095-4dannjjm 4788 9 - - HYPH cord-023095-4dannjjm 4788 10 5 5 CD cord-023095-4dannjjm 4788 11 , , , cord-023095-4dannjjm 4788 12 particularly particularly RB cord-023095-4dannjjm 4788 13 in in IN cord-023095-4dannjjm 4788 14 T3 T3 NNP cord-023095-4dannjjm 4788 15 - - HYPH cord-023095-4dannjjm 4788 16 4 4 CD cord-023095-4dannjjm 4788 17 . . . cord-023095-4dannjjm 4789 1 Genetic genetic JJ cord-023095-4dannjjm 4789 2 and/or and/or CC cord-023095-4dannjjm 4789 3 conformational conformational JJ cord-023095-4dannjjm 4789 4 factors factor NNS cord-023095-4dannjjm 4789 5 , , , cord-023095-4dannjjm 4789 6 such such JJ cord-023095-4dannjjm 4789 7 as as IN cord-023095-4dannjjm 4789 8 weakness weakness NN cord-023095-4dannjjm 4789 9 of of IN cord-023095-4dannjjm 4789 10 the the DT cord-023095-4dannjjm 4789 11 intercapital intercapital NNP cord-023095-4dannjjm 4789 12 ligament ligament NN cord-023095-4dannjjm 4789 13 , , , cord-023095-4dannjjm 4789 14 may may MD cord-023095-4dannjjm 4789 15 predispose predispose VB cord-023095-4dannjjm 4789 16 GSD GSD NNP cord-023095-4dannjjm 4789 17 to to IN cord-023095-4dannjjm 4789 18 this this DT cord-023095-4dannjjm 4789 19 lesion lesion NN cord-023095-4dannjjm 4789 20 . . . cord-023095-4dannjjm 4790 1 Diskospondylitis Diskospondylitis NNP cord-023095-4dannjjm 4790 2 is be VBZ cord-023095-4dannjjm 4790 3 a a DT cord-023095-4dannjjm 4790 4 common common JJ cord-023095-4dannjjm 4790 5 disease disease NN cord-023095-4dannjjm 4790 6 of of IN cord-023095-4dannjjm 4790 7 the the DT cord-023095-4dannjjm 4790 8 canine canine JJ cord-023095-4dannjjm 4790 9 spine spine NN cord-023095-4dannjjm 4790 10 ; ; : cord-023095-4dannjjm 4790 11 however however RB cord-023095-4dannjjm 4790 12 , , , cord-023095-4dannjjm 4790 13 few few JJ cord-023095-4dannjjm 4790 14 reports report NNS cord-023095-4dannjjm 4790 15 of of IN cord-023095-4dannjjm 4790 16 MR MR NNP cord-023095-4dannjjm 4790 17 imaging image VBG cord-023095-4dannjjm 4790 18 findings finding NNS cord-023095-4dannjjm 4790 19 in in IN cord-023095-4dannjjm 4790 20 dogs dog NNS cord-023095-4dannjjm 4790 21 are be VBP cord-023095-4dannjjm 4790 22 available available JJ cord-023095-4dannjjm 4790 23 . . . cord-023095-4dannjjm 4791 1 The the DT cord-023095-4dannjjm 4791 2 purpose purpose NN cord-023095-4dannjjm 4791 3 of of IN cord-023095-4dannjjm 4791 4 this this DT cord-023095-4dannjjm 4791 5 study study NN cord-023095-4dannjjm 4791 6 was be VBD cord-023095-4dannjjm 4791 7 to to TO cord-023095-4dannjjm 4791 8 describe describe VB cord-023095-4dannjjm 4791 9 the the DT cord-023095-4dannjjm 4791 10 signalment signalment JJ cord-023095-4dannjjm 4791 11 , , , cord-023095-4dannjjm 4791 12 clinical clinical JJ cord-023095-4dannjjm 4791 13 and and CC cord-023095-4dannjjm 4791 14 MR MR NNP cord-023095-4dannjjm 4791 15 imaging imaging NN cord-023095-4dannjjm 4791 16 features feature NNS cord-023095-4dannjjm 4791 17 in in IN cord-023095-4dannjjm 4791 18 affected affect VBN cord-023095-4dannjjm 4791 19 dogs dog NNS cord-023095-4dannjjm 4791 20 . . . cord-023095-4dannjjm 4792 1 Twenty twenty CD cord-023095-4dannjjm 4792 2 - - HYPH cord-023095-4dannjjm 4792 3 three three CD cord-023095-4dannjjm 4792 4 dogs dog NNS cord-023095-4dannjjm 4792 5 with with IN cord-023095-4dannjjm 4792 6 a a DT cord-023095-4dannjjm 4792 7 diagnosis diagnosis NN cord-023095-4dannjjm 4792 8 of of IN cord-023095-4dannjjm 4792 9 diskospondylitis diskospondylitis NNP cord-023095-4dannjjm 4792 10 based base VBN cord-023095-4dannjjm 4792 11 on on IN cord-023095-4dannjjm 4792 12 clinical clinical JJ cord-023095-4dannjjm 4792 13 signs sign NNS cord-023095-4dannjjm 4792 14 , , , cord-023095-4dannjjm 4792 15 MR MR NNP cord-023095-4dannjjm 4792 16 imaging imaging NN cord-023095-4dannjjm 4792 17 , , , cord-023095-4dannjjm 4792 18 and and CC cord-023095-4dannjjm 4792 19 urine urine NN cord-023095-4dannjjm 4792 20 , , , cord-023095-4dannjjm 4792 21 blood blood NN cord-023095-4dannjjm 4792 22 , , , cord-023095-4dannjjm 4792 23 CSF CSF NNP cord-023095-4dannjjm 4792 24 and/or and/or CC cord-023095-4dannjjm 4792 25 intervertebral intervertebral JJ cord-023095-4dannjjm 4792 26 disk disk NN cord-023095-4dannjjm 4792 27 cultures culture NNS cord-023095-4dannjjm 4792 28 were be VBD cord-023095-4dannjjm 4792 29 included include VBN cord-023095-4dannjjm 4792 30 . . . cord-023095-4dannjjm 4793 1 Large large JJ cord-023095-4dannjjm 4793 2 breed breed NN cord-023095-4dannjjm 4793 3 dogs dog NNS cord-023095-4dannjjm 4793 4 ( ( -LRB- cord-023095-4dannjjm 4793 5 4 4 CD cord-023095-4dannjjm 4793 6 25 25 CD cord-023095-4dannjjm 4793 7 kg kg NNS cord-023095-4dannjjm 4793 8 ) ) -RRB- cord-023095-4dannjjm 4793 9 accounted account VBD cord-023095-4dannjjm 4793 10 for for IN cord-023095-4dannjjm 4793 11 21of 21of NN cord-023095-4dannjjm 4793 12 the the DT cord-023095-4dannjjm 4793 13 cases case NNS cord-023095-4dannjjm 4793 14 . . . cord-023095-4dannjjm 4794 1 The the DT cord-023095-4dannjjm 4794 2 mean mean JJ cord-023095-4dannjjm 4794 3 age age NN cord-023095-4dannjjm 4794 4 was be VBD cord-023095-4dannjjm 4794 5 6.8 6.8 CD cord-023095-4dannjjm 4794 6 years year NNS cord-023095-4dannjjm 4794 7 with with IN cord-023095-4dannjjm 4794 8 males male NNS cord-023095-4dannjjm 4794 9 and and CC cord-023095-4dannjjm 4794 10 females female NNS cord-023095-4dannjjm 4794 11 equally equally RB cord-023095-4dannjjm 4794 12 represented represent VBD cord-023095-4dannjjm 4794 13 . . . cord-023095-4dannjjm 4795 1 Most Most JJS cord-023095-4dannjjm 4795 2 dogs dog NNS cord-023095-4dannjjm 4795 3 ( ( -LRB- cord-023095-4dannjjm 4795 4 15/23 15/23 CD cord-023095-4dannjjm 4795 5 ) ) -RRB- cord-023095-4dannjjm 4795 6 were be VBD cord-023095-4dannjjm 4795 7 ambulatory ambulatory JJ cord-023095-4dannjjm 4795 8 with with IN cord-023095-4dannjjm 4795 9 varying vary VBG cord-023095-4dannjjm 4795 10 degrees degree NNS cord-023095-4dannjjm 4795 11 of of IN cord-023095-4dannjjm 4795 12 pain pain NN cord-023095-4dannjjm 4795 13 and and CC cord-023095-4dannjjm 4795 14 paresis paresis NN cord-023095-4dannjjm 4795 15 . . . cord-023095-4dannjjm 4796 1 MR MR NNP cord-023095-4dannjjm 4796 2 imaging imaging NN cord-023095-4dannjjm 4796 3 characteristics characteristic NNS cord-023095-4dannjjm 4796 4 of of IN cord-023095-4dannjjm 4796 5 27 27 CD cord-023095-4dannjjm 4796 6 sites site NNS cord-023095-4dannjjm 4796 7 were be VBD cord-023095-4dannjjm 4796 8 reviewed review VBN cord-023095-4dannjjm 4796 9 . . . cord-023095-4dannjjm 4797 1 On on IN cord-023095-4dannjjm 4797 2 T2W t2w CD cord-023095-4dannjjm 4797 3 images image NNS cord-023095-4dannjjm 4797 4 , , , cord-023095-4dannjjm 4797 5 vertebral vertebral JJ cord-023095-4dannjjm 4797 6 endplates endplate NNS cord-023095-4dannjjm 4797 7 were be VBD cord-023095-4dannjjm 4797 8 of of IN cord-023095-4dannjjm 4797 9 mixed mixed JJ cord-023095-4dannjjm 4797 10 signal signal NN cord-023095-4dannjjm 4797 11 intensity intensity NN cord-023095-4dannjjm 4797 12 ( ( -LRB- cord-023095-4dannjjm 4797 13 16/27 16/27 CD cord-023095-4dannjjm 4797 14 ) ) -RRB- cord-023095-4dannjjm 4797 15 while while IN cord-023095-4dannjjm 4797 16 the the DT cord-023095-4dannjjm 4797 17 vertebral vertebral JJ cord-023095-4dannjjm 4797 18 body body NN cord-023095-4dannjjm 4797 19 was be VBD cord-023095-4dannjjm 4797 20 hypointense hypointense NN cord-023095-4dannjjm 4797 21 ( ( -LRB- cord-023095-4dannjjm 4797 22 11/27 11/27 CD cord-023095-4dannjjm 4797 23 ) ) -RRB- cord-023095-4dannjjm 4797 24 . . . cord-023095-4dannjjm 4798 1 The the DT cord-023095-4dannjjm 4798 2 intervertebral intervertebral JJ cord-023095-4dannjjm 4798 3 disk disk NN cord-023095-4dannjjm 4798 4 space space NN cord-023095-4dannjjm 4798 5 was be VBD cord-023095-4dannjjm 4798 6 hyperintense hyperintense NN cord-023095-4dannjjm 4798 7 on on IN cord-023095-4dannjjm 4798 8 T2W T2W NNP cord-023095-4dannjjm 4798 9 ( ( -LRB- cord-023095-4dannjjm 4798 10 16/27 16/27 CD cord-023095-4dannjjm 4798 11 ) ) -RRB- cord-023095-4dannjjm 4798 12 and and CC cord-023095-4dannjjm 4798 13 STIR stir VB cord-023095-4dannjjm 4798 14 ( ( -LRB- cord-023095-4dannjjm 4798 15 14/15 14/15 CD cord-023095-4dannjjm 4798 16 ) ) -RRB- cord-023095-4dannjjm 4798 17 images image NNS cord-023095-4dannjjm 4798 18 and and CC cord-023095-4dannjjm 4798 19 mixed mixed JJ cord-023095-4dannjjm 4798 20 signal signal NN cord-023095-4dannjjm 4798 21 intensity intensity NN cord-023095-4dannjjm 4798 22 ( ( -LRB- cord-023095-4dannjjm 4798 23 7/13 7/13 CD cord-023095-4dannjjm 4798 24 ) ) -RRB- cord-023095-4dannjjm 4798 25 on on IN cord-023095-4dannjjm 4798 26 T1W t1w DT cord-023095-4dannjjm 4798 27 images image NNS cord-023095-4dannjjm 4798 28 . . . cord-023095-4dannjjm 4799 1 Paravertebral Paravertebral NNP cord-023095-4dannjjm 4799 2 soft soft JJ cord-023095-4dannjjm 4799 3 tissue tissue NN cord-023095-4dannjjm 4799 4 hyperintensities hyperintensitie NNS cord-023095-4dannjjm 4799 5 were be VBD cord-023095-4dannjjm 4799 6 noted note VBN cord-023095-4dannjjm 4799 7 on on IN cord-023095-4dannjjm 4799 8 10/27 10/27 CD cord-023095-4dannjjm 4799 9 T2W t2w CD cord-023095-4dannjjm 4799 10 and and CC cord-023095-4dannjjm 4799 11 12/16 12/16 CD cord-023095-4dannjjm 4799 12 STIR stir VB cord-023095-4dannjjm 4799 13 images image NNS cord-023095-4dannjjm 4799 14 . . . cord-023095-4dannjjm 4800 1 Contrast contrast NN cord-023095-4dannjjm 4800 2 enhancement enhancement NN cord-023095-4dannjjm 4800 3 occurred occur VBD cord-023095-4dannjjm 4800 4 at at IN cord-023095-4dannjjm 4800 5 12/19 12/19 CD cord-023095-4dannjjm 4800 6 endplates endplate NNS cord-023095-4dannjjm 4800 7 and and CC cord-023095-4dannjjm 4800 8 15/19 15/19 CD cord-023095-4dannjjm 4800 9 intervertebral intervertebral JJ cord-023095-4dannjjm 4800 10 disk disk NN cord-023095-4dannjjm 4800 11 spaces space NNS cord-023095-4dannjjm 4800 12 . . . cord-023095-4dannjjm 4801 1 Only only RB cord-023095-4dannjjm 4801 2 4/18 4/18 CD cord-023095-4dannjjm 4801 3 vertebral vertebral JJ cord-023095-4dannjjm 4801 4 bodies body NNS cord-023095-4dannjjm 4801 5 and and CC cord-023095-4dannjjm 4801 6 7/18 7/18 CD cord-023095-4dannjjm 4801 7 parvertebral parvertebral JJ cord-023095-4dannjjm 4801 8 soft soft JJ cord-023095-4dannjjm 4801 9 tissues tissue NNS cord-023095-4dannjjm 4801 10 contrast contrast NN cord-023095-4dannjjm 4801 11 enhanced enhance VBN cord-023095-4dannjjm 4801 12 . . . cord-023095-4dannjjm 4802 1 Intramedullary intramedullary JJ cord-023095-4dannjjm 4802 2 spinal spinal JJ cord-023095-4dannjjm 4802 3 cord cord NN cord-023095-4dannjjm 4802 4 T2W t2w CD cord-023095-4dannjjm 4802 5 hyperintensity hyperintensity NN cord-023095-4dannjjm 4802 6 was be VBD cord-023095-4dannjjm 4802 7 noted note VBN cord-023095-4dannjjm 4802 8 at at IN cord-023095-4dannjjm 4802 9 10/23 10/23 CD cord-023095-4dannjjm 4802 10 sites site NNS cord-023095-4dannjjm 4802 11 . . . cord-023095-4dannjjm 4803 1 Spinal spinal JJ cord-023095-4dannjjm 4803 2 cord cord NN cord-023095-4dannjjm 4803 3 or or CC cord-023095-4dannjjm 4803 4 cauda cauda NN cord-023095-4dannjjm 4803 5 equina equina NN cord-023095-4dannjjm 4803 6 compression compression NN cord-023095-4dannjjm 4803 7 occurred occur VBD cord-023095-4dannjjm 4803 8 at at IN cord-023095-4dannjjm 4803 9 22/27 22/27 CD cord-023095-4dannjjm 4803 10 sites site NNS cord-023095-4dannjjm 4803 11 . . . cord-023095-4dannjjm 4804 1 Based base VBN cord-023095-4dannjjm 4804 2 on on IN cord-023095-4dannjjm 4804 3 the the DT cord-023095-4dannjjm 4804 4 Spearman Spearman NNP cord-023095-4dannjjm 4804 5 correlation correlation NN cord-023095-4dannjjm 4804 6 coefficient coefficient NN cord-023095-4dannjjm 4804 7 , , , cord-023095-4dannjjm 4804 8 a a DT cord-023095-4dannjjm 4804 9 significant significant JJ cord-023095-4dannjjm 4804 10 direct direct JJ cord-023095-4dannjjm 4804 11 correlation correlation NN cord-023095-4dannjjm 4804 12 was be VBD cord-023095-4dannjjm 4804 13 found find VBN cord-023095-4dannjjm 4804 14 between between IN cord-023095-4dannjjm 4804 15 the the DT cord-023095-4dannjjm 4804 16 degree degree NN cord-023095-4dannjjm 4804 17 of of IN cord-023095-4dannjjm 4804 18 spinal spinal JJ cord-023095-4dannjjm 4804 19 cord cord NN cord-023095-4dannjjm 4804 20 or or CC cord-023095-4dannjjm 4804 21 cauda cauda FW cord-023095-4dannjjm 4804 22 equina equina NN cord-023095-4dannjjm 4804 23 compression compression NN cord-023095-4dannjjm 4804 24 and and CC cord-023095-4dannjjm 4804 25 the the DT cord-023095-4dannjjm 4804 26 patient patient NN cord-023095-4dannjjm 4804 27 's 's POS cord-023095-4dannjjm 4804 28 neurologic neurologic JJ cord-023095-4dannjjm 4804 29 status status NN cord-023095-4dannjjm 4804 30 ( ( -LRB- cord-023095-4dannjjm 4804 31 P p NN cord-023095-4dannjjm 4804 32 5 5 CD cord-023095-4dannjjm 4804 33 0.0011 0.0011 CD cord-023095-4dannjjm 4804 34 ) ) -RRB- cord-023095-4dannjjm 4804 35 . . . cord-023095-4dannjjm 4805 1 The the DT cord-023095-4dannjjm 4805 2 incidence incidence NN cord-023095-4dannjjm 4805 3 and and CC cord-023095-4dannjjm 4805 4 severity severity NN cord-023095-4dannjjm 4805 5 of of IN cord-023095-4dannjjm 4805 6 spinal spinal JJ cord-023095-4dannjjm 4805 7 cord cord NN cord-023095-4dannjjm 4805 8 compression compression NN cord-023095-4dannjjm 4805 9 in in IN cord-023095-4dannjjm 4805 10 canine canine JJ cord-023095-4dannjjm 4805 11 diskospondylitis diskospondylitis NN cord-023095-4dannjjm 4805 12 may may MD cord-023095-4dannjjm 4805 13 have have VB cord-023095-4dannjjm 4805 14 prognostic prognostic JJ cord-023095-4dannjjm 4805 15 value value NN cord-023095-4dannjjm 4805 16 and and CC cord-023095-4dannjjm 4805 17 may may MD cord-023095-4dannjjm 4805 18 have have VB cord-023095-4dannjjm 4805 19 been be VBN cord-023095-4dannjjm 4805 20 previously previously RB cord-023095-4dannjjm 4805 21 underestimated underestimate VBN cord-023095-4dannjjm 4805 22 using use VBG cord-023095-4dannjjm 4805 23 other other JJ cord-023095-4dannjjm 4805 24 imaging imaging NN cord-023095-4dannjjm 4805 25 modalities modality NNS cord-023095-4dannjjm 4805 26 . . . cord-023095-4dannjjm 4806 1 Hemilaminectomy Hemilaminectomy NNP cord-023095-4dannjjm 4806 2 and and CC cord-023095-4dannjjm 4806 3 pediculectomy pediculectomy NN cord-023095-4dannjjm 4806 4 are be VBP cord-023095-4dannjjm 4806 5 both both DT cord-023095-4dannjjm 4806 6 well well RB cord-023095-4dannjjm 4806 7 described describe VBN cord-023095-4dannjjm 4806 8 and and CC cord-023095-4dannjjm 4806 9 commonly commonly RB cord-023095-4dannjjm 4806 10 utilized utilize VBN cord-023095-4dannjjm 4806 11 techniques technique NNS cord-023095-4dannjjm 4806 12 to to TO cord-023095-4dannjjm 4806 13 access access VB cord-023095-4dannjjm 4806 14 the the DT cord-023095-4dannjjm 4806 15 spinal spinal JJ cord-023095-4dannjjm 4806 16 canal canal NN cord-023095-4dannjjm 4806 17 . . . cord-023095-4dannjjm 4807 1 These these DT cord-023095-4dannjjm 4807 2 procedures procedure NNS cord-023095-4dannjjm 4807 3 are be VBP cord-023095-4dannjjm 4807 4 most most RBS cord-023095-4dannjjm 4807 5 often often RB cord-023095-4dannjjm 4807 6 performed perform VBN cord-023095-4dannjjm 4807 7 to to TO cord-023095-4dannjjm 4807 8 approach approach VB cord-023095-4dannjjm 4807 9 a a DT cord-023095-4dannjjm 4807 10 compressive compressive JJ cord-023095-4dannjjm 4807 11 lesion lesion NN cord-023095-4dannjjm 4807 12 , , , cord-023095-4dannjjm 4807 13 such such JJ cord-023095-4dannjjm 4807 14 as as IN cord-023095-4dannjjm 4807 15 intervertebral intervertebral JJ cord-023095-4dannjjm 4807 16 disc disc NN cord-023095-4dannjjm 4807 17 disease disease NN cord-023095-4dannjjm 4807 18 and and CC cord-023095-4dannjjm 4807 19 neoplasia neoplasia NN cord-023095-4dannjjm 4807 20 , , , cord-023095-4dannjjm 4807 21 the the DT cord-023095-4dannjjm 4807 22 goal goal NN cord-023095-4dannjjm 4807 23 being be VBG cord-023095-4dannjjm 4807 24 adequate adequate JJ cord-023095-4dannjjm 4807 25 visualization visualization NN cord-023095-4dannjjm 4807 26 of of IN cord-023095-4dannjjm 4807 27 the the DT cord-023095-4dannjjm 4807 28 spinal spinal JJ cord-023095-4dannjjm 4807 29 canal canal NN cord-023095-4dannjjm 4807 30 and and CC cord-023095-4dannjjm 4807 31 access access NN cord-023095-4dannjjm 4807 32 to to IN cord-023095-4dannjjm 4807 33 the the DT cord-023095-4dannjjm 4807 34 offending offending JJ cord-023095-4dannjjm 4807 35 lesion lesion NN cord-023095-4dannjjm 4807 36 . . . cord-023095-4dannjjm 4808 1 A a DT cord-023095-4dannjjm 4808 2 proposed propose VBN cord-023095-4dannjjm 4808 3 benefit benefit NN cord-023095-4dannjjm 4808 4 of of IN cord-023095-4dannjjm 4808 5 pediculectomy pediculectomy NN cord-023095-4dannjjm 4808 6 is be VBZ cord-023095-4dannjjm 4808 7 preservation preservation NN cord-023095-4dannjjm 4808 8 of of IN cord-023095-4dannjjm 4808 9 the the DT cord-023095-4dannjjm 4808 10 articular articular JJ cord-023095-4dannjjm 4808 11 facets facet NNS cord-023095-4dannjjm 4808 12 and and CC cord-023095-4dannjjm 4808 13 thus thus RB cord-023095-4dannjjm 4808 14 better well RBR cord-023095-4dannjjm 4808 15 maintaining maintain VBG cord-023095-4dannjjm 4808 16 stability stability NN cord-023095-4dannjjm 4808 17 of of IN cord-023095-4dannjjm 4808 18 the the DT cord-023095-4dannjjm 4808 19 vertebral vertebral JJ cord-023095-4dannjjm 4808 20 column column NN cord-023095-4dannjjm 4808 21 , , , cord-023095-4dannjjm 4808 22 but but CC cord-023095-4dannjjm 4808 23 at at IN cord-023095-4dannjjm 4808 24 the the DT cord-023095-4dannjjm 4808 25 cost cost NN cord-023095-4dannjjm 4808 26 of of IN cord-023095-4dannjjm 4808 27 reduced reduce VBN cord-023095-4dannjjm 4808 28 access access NN cord-023095-4dannjjm 4808 29 to to IN cord-023095-4dannjjm 4808 30 the the DT cord-023095-4dannjjm 4808 31 spinal spinal JJ cord-023095-4dannjjm 4808 32 canal canal NN cord-023095-4dannjjm 4808 33 . . . cord-023095-4dannjjm 4809 1 The the DT cord-023095-4dannjjm 4809 2 purpose purpose NN cord-023095-4dannjjm 4809 3 of of IN cord-023095-4dannjjm 4809 4 this this DT cord-023095-4dannjjm 4809 5 study study NN cord-023095-4dannjjm 4809 6 was be VBD cord-023095-4dannjjm 4809 7 to to TO cord-023095-4dannjjm 4809 8 describe describe VB cord-023095-4dannjjm 4809 9 standardized standardized JJ cord-023095-4dannjjm 4809 10 anatomical anatomical JJ cord-023095-4dannjjm 4809 11 limits limit NNS cord-023095-4dannjjm 4809 12 of of IN cord-023095-4dannjjm 4809 13 each each DT cord-023095-4dannjjm 4809 14 technique technique NN cord-023095-4dannjjm 4809 15 and and CC cord-023095-4dannjjm 4809 16 report report VB cord-023095-4dannjjm 4809 17 any any DT cord-023095-4dannjjm 4809 18 observed observed JJ cord-023095-4dannjjm 4809 19 differences difference NNS cord-023095-4dannjjm 4809 20 that that WDT cord-023095-4dannjjm 4809 21 could could MD cord-023095-4dannjjm 4809 22 be be VB cord-023095-4dannjjm 4809 23 considered consider VBN cord-023095-4dannjjm 4809 24 during during IN cord-023095-4dannjjm 4809 25 presurgical presurgical JJ cord-023095-4dannjjm 4809 26 planning planning NN cord-023095-4dannjjm 4809 27 . . . cord-023095-4dannjjm 4810 1 Ten ten CD cord-023095-4dannjjm 4810 2 canine canine JJ cord-023095-4dannjjm 4810 3 cadavers cadaver NNS cord-023095-4dannjjm 4810 4 had have VBD cord-023095-4dannjjm 4810 5 both both DT cord-023095-4dannjjm 4810 6 procedures procedure NNS cord-023095-4dannjjm 4810 7 performed perform VBN cord-023095-4dannjjm 4810 8 on on IN cord-023095-4dannjjm 4810 9 opposite opposite JJ cord-023095-4dannjjm 4810 10 sides side NNS cord-023095-4dannjjm 4810 11 to to TO cord-023095-4dannjjm 4810 12 access access VB cord-023095-4dannjjm 4810 13 the the DT cord-023095-4dannjjm 4810 14 T11 T11 NNP cord-023095-4dannjjm 4810 15 - - HYPH cord-023095-4dannjjm 4810 16 12 12 CD cord-023095-4dannjjm 4810 17 , , , cord-023095-4dannjjm 4810 18 T13-L1 T13-L1 NNP cord-023095-4dannjjm 4810 19 , , , cord-023095-4dannjjm 4810 20 and and CC cord-023095-4dannjjm 4810 21 L2 L2 NNP cord-023095-4dannjjm 4810 22 - - HYPH cord-023095-4dannjjm 4810 23 3 3 CD cord-023095-4dannjjm 4810 24 spinal spinal JJ cord-023095-4dannjjm 4810 25 canal canal NN cord-023095-4dannjjm 4810 26 . . . cord-023095-4dannjjm 4811 1 Measurements measurement NNS cord-023095-4dannjjm 4811 2 were be VBD cord-023095-4dannjjm 4811 3 obtained obtain VBN cord-023095-4dannjjm 4811 4 after after IN cord-023095-4dannjjm 4811 5 performing perform VBG cord-023095-4dannjjm 4811 6 a a DT cord-023095-4dannjjm 4811 7 computed compute VBN cord-023095-4dannjjm 4811 8 tomography tomography NN cord-023095-4dannjjm 4811 9 study study NN cord-023095-4dannjjm 4811 10 of of IN cord-023095-4dannjjm 4811 11 the the DT cord-023095-4dannjjm 4811 12 spine spine NN cord-023095-4dannjjm 4811 13 and and CC cord-023095-4dannjjm 4811 14 recorded record VBD cord-023095-4dannjjm 4811 15 from from IN cord-023095-4dannjjm 4811 16 the the DT cord-023095-4dannjjm 4811 17 transverse transverse JJ cord-023095-4dannjjm 4811 18 slice slice NN cord-023095-4dannjjm 4811 19 most most JJS cord-023095-4dannjjm 4811 20 representative representative NN cord-023095-4dannjjm 4811 21 of of IN cord-023095-4dannjjm 4811 22 the the DT cord-023095-4dannjjm 4811 23 defect defect NN cord-023095-4dannjjm 4811 24 . . . cord-023095-4dannjjm 4812 1 The the DT cord-023095-4dannjjm 4812 2 surgical surgical JJ cord-023095-4dannjjm 4812 3 technique technique NN cord-023095-4dannjjm 4812 4 , , , cord-023095-4dannjjm 4812 5 vertebral vertebral JJ cord-023095-4dannjjm 4812 6 site site NN cord-023095-4dannjjm 4812 7 , , , cord-023095-4dannjjm 4812 8 and and CC cord-023095-4dannjjm 4812 9 side side NN cord-023095-4dannjjm 4812 10 of of IN cord-023095-4dannjjm 4812 11 vertebral vertebral JJ cord-023095-4dannjjm 4812 12 column column NN cord-023095-4dannjjm 4812 13 were be VBD cord-023095-4dannjjm 4812 14 compared compare VBN cord-023095-4dannjjm 4812 15 with with IN cord-023095-4dannjjm 4812 16 the the DT cord-023095-4dannjjm 4812 17 mean mean JJ cord-023095-4dannjjm 4812 18 spinal spinal JJ cord-023095-4dannjjm 4812 19 canal canal NN cord-023095-4dannjjm 4812 20 and and CC cord-023095-4dannjjm 4812 21 defect defect NN cord-023095-4dannjjm 4812 22 height height NN cord-023095-4dannjjm 4812 23 using use VBG cord-023095-4dannjjm 4812 24 a a DT cord-023095-4dannjjm 4812 25 covariate covariate NN cord-023095-4dannjjm 4812 26 model model NN cord-023095-4dannjjm 4812 27 . . . cord-023095-4dannjjm 4813 1 Dorsal dorsal JJ cord-023095-4dannjjm 4813 2 and and CC cord-023095-4dannjjm 4813 3 ventral ventral JJ cord-023095-4dannjjm 4813 4 remnant remnant JJ cord-023095-4dannjjm 4813 5 lamina lamina NNP cord-023095-4dannjjm 4813 6 heights height NNS cord-023095-4dannjjm 4813 7 were be VBD cord-023095-4dannjjm 4813 8 also also RB cord-023095-4dannjjm 4813 9 compared compare VBN cord-023095-4dannjjm 4813 10 . . . cord-023095-4dannjjm 4814 1 The the DT cord-023095-4dannjjm 4814 2 height height NN cord-023095-4dannjjm 4814 3 of of IN cord-023095-4dannjjm 4814 4 the the DT cord-023095-4dannjjm 4814 5 defect defect NN cord-023095-4dannjjm 4814 6 relative relative JJ cord-023095-4dannjjm 4814 7 to to IN cord-023095-4dannjjm 4814 8 the the DT cord-023095-4dannjjm 4814 9 spinal spinal JJ cord-023095-4dannjjm 4814 10 canal canal NN cord-023095-4dannjjm 4814 11 was be VBD cord-023095-4dannjjm 4814 12 76 76 CD cord-023095-4dannjjm 4814 13 - - SYM cord-023095-4dannjjm 4814 14 87 87 CD cord-023095-4dannjjm 4814 15 % % NN cord-023095-4dannjjm 4814 16 with with IN cord-023095-4dannjjm 4814 17 hemilaminectomy hemilaminectomy NN cord-023095-4dannjjm 4814 18 and and CC cord-023095-4dannjjm 4814 19 58 58 CD cord-023095-4dannjjm 4814 20 - - SYM cord-023095-4dannjjm 4814 21 75 75 CD cord-023095-4dannjjm 4814 22 % % NN cord-023095-4dannjjm 4814 23 with with IN cord-023095-4dannjjm 4814 24 pediculectomy pediculectomy NN cord-023095-4dannjjm 4814 25 . . . cord-023095-4dannjjm 4815 1 The the DT cord-023095-4dannjjm 4815 2 observed observed JJ cord-023095-4dannjjm 4815 3 difference difference NN cord-023095-4dannjjm 4815 4 in in IN cord-023095-4dannjjm 4815 5 defect defect NN cord-023095-4dannjjm 4815 6 height height NN cord-023095-4dannjjm 4815 7 of of IN cord-023095-4dannjjm 4815 8 12 12 CD cord-023095-4dannjjm 4815 9 - - SYM cord-023095-4dannjjm 4815 10 18 18 CD cord-023095-4dannjjm 4815 11 % % NN cord-023095-4dannjjm 4815 12 ( ( -LRB- cord-023095-4dannjjm 4815 13 p p NN cord-023095-4dannjjm 4815 14 o o NN cord-023095-4dannjjm 4815 15 0.0001 0.0001 CD cord-023095-4dannjjm 4815 16 ) ) -RRB- cord-023095-4dannjjm 4815 17 and and CC cord-023095-4dannjjm 4815 18 varied vary VBN cord-023095-4dannjjm 4815 19 with with IN cord-023095-4dannjjm 4815 20 spinal spinal JJ cord-023095-4dannjjm 4815 21 canal canal NN cord-023095-4dannjjm 4815 22 height height NN cord-023095-4dannjjm 4815 23 . . . cord-023095-4dannjjm 4816 1 Dorsal dorsal JJ cord-023095-4dannjjm 4816 2 remnant remnant NN cord-023095-4dannjjm 4816 3 lamina lamina NNP cord-023095-4dannjjm 4816 4 height height NN cord-023095-4dannjjm 4816 5 was be VBD cord-023095-4dannjjm 4816 6 0.9 0.9 CD cord-023095-4dannjjm 4816 7 - - SYM cord-023095-4dannjjm 4816 8 2.4 2.4 CD cord-023095-4dannjjm 4816 9 % % NN cord-023095-4dannjjm 4816 10 of of IN cord-023095-4dannjjm 4816 11 spinal spinal JJ cord-023095-4dannjjm 4816 12 canal canal NN cord-023095-4dannjjm 4816 13 height height NN cord-023095-4dannjjm 4816 14 with with IN cord-023095-4dannjjm 4816 15 hemilaminectomy hemilaminectomy NN cord-023095-4dannjjm 4816 16 and and CC cord-023095-4dannjjm 4816 17 7 7 CD cord-023095-4dannjjm 4816 18 - - SYM cord-023095-4dannjjm 4816 19 19 19 CD cord-023095-4dannjjm 4816 20 % % NN cord-023095-4dannjjm 4816 21 with with IN cord-023095-4dannjjm 4816 22 pediculectomy pediculectomy NN cord-023095-4dannjjm 4816 23 . . . cord-023095-4dannjjm 4817 1 Ventral ventral JJ cord-023095-4dannjjm 4817 2 remnant remnant JJ cord-023095-4dannjjm 4817 3 lamina lamina NN cord-023095-4dannjjm 4817 4 height height NN cord-023095-4dannjjm 4817 5 ranged range VBD cord-023095-4dannjjm 4817 6 from from IN cord-023095-4dannjjm 4817 7 1 1 CD cord-023095-4dannjjm 4817 8 - - SYM cord-023095-4dannjjm 4817 9 2 2 CD cord-023095-4dannjjm 4817 10 % % NN cord-023095-4dannjjm 4817 11 and and CC cord-023095-4dannjjm 4817 12 0.6 0.6 CD cord-023095-4dannjjm 4817 13 - - SYM cord-023095-4dannjjm 4817 14 2.3 2.3 CD cord-023095-4dannjjm 4817 15 % % NN cord-023095-4dannjjm 4817 16 , , , cord-023095-4dannjjm 4817 17 respectively respectively RB cord-023095-4dannjjm 4817 18 , , , cord-023095-4dannjjm 4817 19 though though IN cord-023095-4dannjjm 4817 20 the the DT cord-023095-4dannjjm 4817 21 difference difference NN cord-023095-4dannjjm 4817 22 was be VBD cord-023095-4dannjjm 4817 23 not not RB cord-023095-4dannjjm 4817 24 statistically statistically RB cord-023095-4dannjjm 4817 25 significant significant JJ cord-023095-4dannjjm 4817 26 . . . cord-023095-4dannjjm 4818 1 While while IN cord-023095-4dannjjm 4818 2 a a DT cord-023095-4dannjjm 4818 3 larger large JJR cord-023095-4dannjjm 4818 4 defect defect NN cord-023095-4dannjjm 4818 5 is be VBZ cord-023095-4dannjjm 4818 6 expected expect VBN cord-023095-4dannjjm 4818 7 with with IN cord-023095-4dannjjm 4818 8 a a DT cord-023095-4dannjjm 4818 9 hemilaminectomy hemilaminectomy NN cord-023095-4dannjjm 4818 10 procedure procedure NN cord-023095-4dannjjm 4818 11 , , , cord-023095-4dannjjm 4818 12 our -PRON- PRP$ cord-023095-4dannjjm 4818 13 results result NNS cord-023095-4dannjjm 4818 14 demonstrate demonstrate VBP cord-023095-4dannjjm 4818 15 that that IN cord-023095-4dannjjm 4818 16 this this DT cord-023095-4dannjjm 4818 17 difference difference NN cord-023095-4dannjjm 4818 18 increases increase VBZ cord-023095-4dannjjm 4818 19 with with IN cord-023095-4dannjjm 4818 20 increasing increase VBG cord-023095-4dannjjm 4818 21 spinal spinal JJ cord-023095-4dannjjm 4818 22 canal canal NN cord-023095-4dannjjm 4818 23 height height NN cord-023095-4dannjjm 4818 24 . . . cord-023095-4dannjjm 4819 1 Interestingly interestingly RB cord-023095-4dannjjm 4819 2 , , , cord-023095-4dannjjm 4819 3 the the DT cord-023095-4dannjjm 4819 4 proportion proportion NN cord-023095-4dannjjm 4819 5 of of IN cord-023095-4dannjjm 4819 6 exposed expose VBN cord-023095-4dannjjm 4819 7 spinal spinal JJ cord-023095-4dannjjm 4819 8 canal canal NN cord-023095-4dannjjm 4819 9 decreases decrease NNS cord-023095-4dannjjm 4819 10 with with IN cord-023095-4dannjjm 4819 11 increasing increase VBG cord-023095-4dannjjm 4819 12 canal canal NN cord-023095-4dannjjm 4819 13 height height NN cord-023095-4dannjjm 4819 14 for for IN cord-023095-4dannjjm 4819 15 both both DT cord-023095-4dannjjm 4819 16 procedures procedure NNS cord-023095-4dannjjm 4819 17 . . . cord-023095-4dannjjm 4820 1 The the DT cord-023095-4dannjjm 4820 2 difference difference NN cord-023095-4dannjjm 4820 3 in in IN cord-023095-4dannjjm 4820 4 defect defect NN cord-023095-4dannjjm 4820 5 height height NN cord-023095-4dannjjm 4820 6 between between IN cord-023095-4dannjjm 4820 7 techniques technique NNS cord-023095-4dannjjm 4820 8 was be VBD cord-023095-4dannjjm 4820 9 due due JJ cord-023095-4dannjjm 4820 10 to to IN cord-023095-4dannjjm 4820 11 greater great JJR cord-023095-4dannjjm 4820 12 removal removal NN cord-023095-4dannjjm 4820 13 of of IN cord-023095-4dannjjm 4820 14 the the DT cord-023095-4dannjjm 4820 15 dorsal dorsal JJ cord-023095-4dannjjm 4820 16 spinal spinal JJ cord-023095-4dannjjm 4820 17 canal canal NN cord-023095-4dannjjm 4820 18 , , , cord-023095-4dannjjm 4820 19 possibly possibly RB cord-023095-4dannjjm 4820 20 making make VBG cord-023095-4dannjjm 4820 21 the the DT cord-023095-4dannjjm 4820 22 hemilaminectomy hemilaminectomy NN cord-023095-4dannjjm 4820 23 technique technique NN cord-023095-4dannjjm 4820 24 better well RBR cord-023095-4dannjjm 4820 25 suited suited JJ cord-023095-4dannjjm 4820 26 for for IN cord-023095-4dannjjm 4820 27 more more JJR cord-023095-4dannjjm 4820 28 dorsal dorsal JJ cord-023095-4dannjjm 4820 29 lesions lesion NNS cord-023095-4dannjjm 4820 30 , , , cord-023095-4dannjjm 4820 31 while while IN cord-023095-4dannjjm 4820 32 no no DT cord-023095-4dannjjm 4820 33 statistically statistically RB cord-023095-4dannjjm 4820 34 difference difference NN cord-023095-4dannjjm 4820 35 in in IN cord-023095-4dannjjm 4820 36 access access NN cord-023095-4dannjjm 4820 37 to to IN cord-023095-4dannjjm 4820 38 the the DT cord-023095-4dannjjm 4820 39 ventral ventral JJ cord-023095-4dannjjm 4820 40 canal canal NN cord-023095-4dannjjm 4820 41 is be VBZ cord-023095-4dannjjm 4820 42 observed observe VBN cord-023095-4dannjjm 4820 43 . . . cord-023095-4dannjjm 4821 1 No no DT cord-023095-4dannjjm 4821 2 effect effect NN cord-023095-4dannjjm 4821 3 of of IN cord-023095-4dannjjm 4821 4 vertebral vertebral JJ cord-023095-4dannjjm 4821 5 site site NN cord-023095-4dannjjm 4821 6 was be VBD cord-023095-4dannjjm 4821 7 detected detect VBN cord-023095-4dannjjm 4821 8 . . . cord-023095-4dannjjm 4822 1 Of of IN cord-023095-4dannjjm 4822 2 note note NN cord-023095-4dannjjm 4822 3 was be VBD cord-023095-4dannjjm 4822 4 the the DT cord-023095-4dannjjm 4822 5 involvement involvement NN cord-023095-4dannjjm 4822 6 of of IN cord-023095-4dannjjm 4822 7 articular articular JJ cord-023095-4dannjjm 4822 8 facets facet NNS cord-023095-4dannjjm 4822 9 in in IN cord-023095-4dannjjm 4822 10 half half NN cord-023095-4dannjjm 4822 11 of of IN cord-023095-4dannjjm 4822 12 the the DT cord-023095-4dannjjm 4822 13 pediculectomy pediculectomy NN cord-023095-4dannjjm 4822 14 defects defect NNS cord-023095-4dannjjm 4822 15 , , , cord-023095-4dannjjm 4822 16 involving involve VBG cord-023095-4dannjjm 4822 17 an an DT cord-023095-4dannjjm 4822 18 average average NN cord-023095-4dannjjm 4822 19 of of IN cord-023095-4dannjjm 4822 20 22 22 CD cord-023095-4dannjjm 4822 21 % % NN cord-023095-4dannjjm 4822 22 of of IN cord-023095-4dannjjm 4822 23 the the DT cord-023095-4dannjjm 4822 24 articular articular JJ cord-023095-4dannjjm 4822 25 facet facet NN cord-023095-4dannjjm 4822 26 height height NN cord-023095-4dannjjm 4822 27 . . . cord-023095-4dannjjm 4823 1 This this DT cord-023095-4dannjjm 4823 2 result result NN cord-023095-4dannjjm 4823 3 questions question VBZ cord-023095-4dannjjm 4823 4 the the DT cord-023095-4dannjjm 4823 5 suggested suggest VBN cord-023095-4dannjjm 4823 6 benefit benefit NN cord-023095-4dannjjm 4823 7 for for IN cord-023095-4dannjjm 4823 8 the the DT cord-023095-4dannjjm 4823 9 vertebral vertebral JJ cord-023095-4dannjjm 4823 10 stability stability NN cord-023095-4dannjjm 4823 11 , , , cord-023095-4dannjjm 4823 12 but but CC cord-023095-4dannjjm 4823 13 further further JJ cord-023095-4dannjjm 4823 14 biomechanical biomechanical JJ cord-023095-4dannjjm 4823 15 studies study NNS cord-023095-4dannjjm 4823 16 would would MD cord-023095-4dannjjm 4823 17 be be VB cord-023095-4dannjjm 4823 18 required require VBN cord-023095-4dannjjm 4823 19 . . . cord-023095-4dannjjm 4824 1 Low low JJ cord-023095-4dannjjm 4824 2 level level NN cord-023095-4dannjjm 4824 3 laser laser NN cord-023095-4dannjjm 4824 4 therapy therapy NN cord-023095-4dannjjm 4824 5 ( ( -LRB- cord-023095-4dannjjm 4824 6 LLLT LLLT NNP cord-023095-4dannjjm 4824 7 ) ) -RRB- cord-023095-4dannjjm 4824 8 is be VBZ cord-023095-4dannjjm 4824 9 a a DT cord-023095-4dannjjm 4824 10 treatment treatment NN cord-023095-4dannjjm 4824 11 used use VBN cord-023095-4dannjjm 4824 12 in in IN cord-023095-4dannjjm 4824 13 human human JJ cord-023095-4dannjjm 4824 14 and and CC cord-023095-4dannjjm 4824 15 veterinary veterinary JJ cord-023095-4dannjjm 4824 16 medicine medicine NN cord-023095-4dannjjm 4824 17 for for IN cord-023095-4dannjjm 4824 18 a a DT cord-023095-4dannjjm 4824 19 variety variety NN cord-023095-4dannjjm 4824 20 of of IN cord-023095-4dannjjm 4824 21 clinical clinical JJ cord-023095-4dannjjm 4824 22 syndromes syndrome NNS cord-023095-4dannjjm 4824 23 . . . cord-023095-4dannjjm 4825 1 Some some DT cord-023095-4dannjjm 4825 2 uses use NNS cord-023095-4dannjjm 4825 3 in in IN cord-023095-4dannjjm 4825 4 human human JJ cord-023095-4dannjjm 4825 5 medicine medicine NN cord-023095-4dannjjm 4825 6 include include VBP cord-023095-4dannjjm 4825 7 acute acute JJ cord-023095-4dannjjm 4825 8 pain pain NN cord-023095-4dannjjm 4825 9 associated associate VBN cord-023095-4dannjjm 4825 10 with with IN cord-023095-4dannjjm 4825 11 osteoarthritis osteoarthritis NN cord-023095-4dannjjm 4825 12 , , , cord-023095-4dannjjm 4825 13 rheumatoid rheumatoid NN cord-023095-4dannjjm 4825 14 arthritis arthritis NN cord-023095-4dannjjm 4825 15 , , , cord-023095-4dannjjm 4825 16 tendonitis tendonitis NN cord-023095-4dannjjm 4825 17 , , , cord-023095-4dannjjm 4825 18 TMJ TMJ NNP cord-023095-4dannjjm 4825 19 disorders disorder NNS cord-023095-4dannjjm 4825 20 , , , cord-023095-4dannjjm 4825 21 chronic chronic JJ cord-023095-4dannjjm 4825 22 joint joint JJ cord-023095-4dannjjm 4825 23 disorders disorder NNS cord-023095-4dannjjm 4825 24 , , , cord-023095-4dannjjm 4825 25 and and CC cord-023095-4dannjjm 4825 26 wound wind VBD cord-023095-4dannjjm 4825 27 healing healing NN cord-023095-4dannjjm 4825 28 . . . cord-023095-4dannjjm 4826 1 Research research NN cord-023095-4dannjjm 4826 2 is be VBZ cord-023095-4dannjjm 4826 3 currently currently RB cord-023095-4dannjjm 4826 4 on on RB cord-023095-4dannjjm 4826 5 - - HYPH cord-023095-4dannjjm 4826 6 going go VBG cord-023095-4dannjjm 4826 7 to to TO cord-023095-4dannjjm 4826 8 determine determine VB cord-023095-4dannjjm 4826 9 the the DT cord-023095-4dannjjm 4826 10 adequate adequate JJ cord-023095-4dannjjm 4826 11 wavelengths wavelength NNS cord-023095-4dannjjm 4826 12 to to TO cord-023095-4dannjjm 4826 13 promote promote VB cord-023095-4dannjjm 4826 14 effective effective JJ cord-023095-4dannjjm 4826 15 treatment treatment NN cord-023095-4dannjjm 4826 16 results result NNS cord-023095-4dannjjm 4826 17 with with IN cord-023095-4dannjjm 4826 18 LLLT LLLT NNP cord-023095-4dannjjm 4826 19 in in IN cord-023095-4dannjjm 4826 20 these these DT cord-023095-4dannjjm 4826 21 conditions condition NNS cord-023095-4dannjjm 4826 22 . . . cord-023095-4dannjjm 4827 1 It -PRON- PRP cord-023095-4dannjjm 4827 2 is be VBZ cord-023095-4dannjjm 4827 3 purported purport VBN cord-023095-4dannjjm 4827 4 that that IN cord-023095-4dannjjm 4827 5 LLLT LLLT NNP cord-023095-4dannjjm 4827 6 acts act VBZ cord-023095-4dannjjm 4827 7 via via IN cord-023095-4dannjjm 4827 8 the the DT cord-023095-4dannjjm 4827 9 mitochondria mitochondrion NNS cord-023095-4dannjjm 4827 10 to to TO cord-023095-4dannjjm 4827 11 increase increase VB cord-023095-4dannjjm 4827 12 cellular cellular JJ cord-023095-4dannjjm 4827 13 metabolism metabolism NN cord-023095-4dannjjm 4827 14 promoting promote VBG cord-023095-4dannjjm 4827 15 wound wound NN cord-023095-4dannjjm 4827 16 healing healing NN cord-023095-4dannjjm 4827 17 and and CC cord-023095-4dannjjm 4827 18 a a DT cord-023095-4dannjjm 4827 19 decrease decrease NN cord-023095-4dannjjm 4827 20 in in IN cord-023095-4dannjjm 4827 21 pain pain NN cord-023095-4dannjjm 4827 22 and and CC cord-023095-4dannjjm 4827 23 inflammation inflammation NN cord-023095-4dannjjm 4827 24 . . . cord-023095-4dannjjm 4828 1 In in IN cord-023095-4dannjjm 4828 2 this this DT cord-023095-4dannjjm 4828 3 study study NN cord-023095-4dannjjm 4828 4 , , , cord-023095-4dannjjm 4828 5 we -PRON- PRP cord-023095-4dannjjm 4828 6 hypothesized hypothesize VBD cord-023095-4dannjjm 4828 7 that that IN cord-023095-4dannjjm 4828 8 dogs dog NNS cord-023095-4dannjjm 4828 9 treated treat VBN cord-023095-4dannjjm 4828 10 with with IN cord-023095-4dannjjm 4828 11 LLLT LLLT NNP cord-023095-4dannjjm 4828 12 in in IN cord-023095-4dannjjm 4828 13 conjunction conjunction NN cord-023095-4dannjjm 4828 14 with with IN cord-023095-4dannjjm 4828 15 hemilaminectomy hemilaminectomy NN cord-023095-4dannjjm 4828 16 would would MD cord-023095-4dannjjm 4828 17 display display VB cord-023095-4dannjjm 4828 18 quicker quick JJR cord-023095-4dannjjm 4828 19 recovery recovery NN cord-023095-4dannjjm 4828 20 times time NNS cord-023095-4dannjjm 4828 21 regardless regardless RB cord-023095-4dannjjm 4828 22 of of IN cord-023095-4dannjjm 4828 23 the the DT cord-023095-4dannjjm 4828 24 presence presence NN cord-023095-4dannjjm 4828 25 or or CC cord-023095-4dannjjm 4828 26 absence absence NN cord-023095-4dannjjm 4828 27 of of IN cord-023095-4dannjjm 4828 28 deep deep JJ cord-023095-4dannjjm 4828 29 pain pain NN cord-023095-4dannjjm 4828 30 sensation sensation NN cord-023095-4dannjjm 4828 31 . . . cord-023095-4dannjjm 4829 1 Seventeen seventeen CD cord-023095-4dannjjm 4829 2 dogs dog NNS cord-023095-4dannjjm 4829 3 ( ( -LRB- cord-023095-4dannjjm 4829 4 9 9 CD cord-023095-4dannjjm 4829 5 Dachshunds Dachshunds NNPS cord-023095-4dannjjm 4829 6 , , , cord-023095-4dannjjm 4829 7 2 2 CD cord-023095-4dannjjm 4829 8 Chihuahuas Chihuahuas NNPS cord-023095-4dannjjm 4829 9 , , , cord-023095-4dannjjm 4829 10 2 2 CD cord-023095-4dannjjm 4829 11 French French NNP cord-023095-4dannjjm 4829 12 Bulldogs Bulldogs NNPS cord-023095-4dannjjm 4829 13 , , , cord-023095-4dannjjm 4829 14 2 2 CD cord-023095-4dannjjm 4829 15 Lhasa Lhasa NNP cord-023095-4dannjjm 4829 16 Ahpsos Ahpsos NNP cord-023095-4dannjjm 4829 17 , , , cord-023095-4dannjjm 4829 18 and and CC cord-023095-4dannjjm 4829 19 1 1 CD cord-023095-4dannjjm 4829 20 each each DT cord-023095-4dannjjm 4829 21 of of IN cord-023095-4dannjjm 4829 22 a a DT cord-023095-4dannjjm 4829 23 Pembroke Pembroke NNP cord-023095-4dannjjm 4829 24 Welsch Welsch NNP cord-023095-4dannjjm 4829 25 Corgi Corgi NNP cord-023095-4dannjjm 4829 26 , , , cord-023095-4dannjjm 4829 27 and and CC cord-023095-4dannjjm 4829 28 a a DT cord-023095-4dannjjm 4829 29 Miniature Miniature NNP cord-023095-4dannjjm 4829 30 Poodle Poodle NNP cord-023095-4dannjjm 4829 31 ) ) -RRB- cord-023095-4dannjjm 4829 32 were be VBD cord-023095-4dannjjm 4829 33 selected select VBN cord-023095-4dannjjm 4829 34 and and CC cord-023095-4dannjjm 4829 35 divided divide VBN cord-023095-4dannjjm 4829 36 into into IN cord-023095-4dannjjm 4829 37 two two CD cord-023095-4dannjjm 4829 38 groups group NNS cord-023095-4dannjjm 4829 39 . . . cord-023095-4dannjjm 4830 1 The the DT cord-023095-4dannjjm 4830 2 dogs dog NNS cord-023095-4dannjjm 4830 3 ranged range VBD cord-023095-4dannjjm 4830 4 in in IN cord-023095-4dannjjm 4830 5 age age NN cord-023095-4dannjjm 4830 6 from from IN cord-023095-4dannjjm 4830 7 2 2 CD cord-023095-4dannjjm 4830 8 to to IN cord-023095-4dannjjm 4830 9 11 11 CD cord-023095-4dannjjm 4830 10 years year NNS cord-023095-4dannjjm 4830 11 old old JJ cord-023095-4dannjjm 4830 12 , , , cord-023095-4dannjjm 4830 13 weighed weigh VBD cord-023095-4dannjjm 4830 14 between between IN cord-023095-4dannjjm 4830 15 7 7 CD cord-023095-4dannjjm 4830 16 and and CC cord-023095-4dannjjm 4830 17 33 33 CD cord-023095-4dannjjm 4830 18 pounds pound NNS cord-023095-4dannjjm 4830 19 , , , cord-023095-4dannjjm 4830 20 and and CC cord-023095-4dannjjm 4830 21 underwent undergo VBD cord-023095-4dannjjm 4830 22 hemilaminectamies hemilaminectamie NNS cord-023095-4dannjjm 4830 23 after after IN cord-023095-4dannjjm 4830 24 acute acute JJ cord-023095-4dannjjm 4830 25 onset onset NN cord-023095-4dannjjm 4830 26 of of IN cord-023095-4dannjjm 4830 27 paraplegia paraplegia NN cord-023095-4dannjjm 4830 28 secondary secondary JJ cord-023095-4dannjjm 4830 29 to to IN cord-023095-4dannjjm 4830 30 intervertebral intervertebral JJ cord-023095-4dannjjm 4830 31 disc disc NN cord-023095-4dannjjm 4830 32 disease disease NN cord-023095-4dannjjm 4830 33 ( ( -LRB- cord-023095-4dannjjm 4830 34 surgically surgically RB cord-023095-4dannjjm 4830 35 confirmed confirm VBN cord-023095-4dannjjm 4830 36 ) ) -RRB- cord-023095-4dannjjm 4830 37 . . . cord-023095-4dannjjm 4831 1 One one CD cord-023095-4dannjjm 4831 2 group group NN cord-023095-4dannjjm 4831 3 received receive VBD cord-023095-4dannjjm 4831 4 laser laser NN cord-023095-4dannjjm 4831 5 treatments treatment NNS cord-023095-4dannjjm 4831 6 on on IN cord-023095-4dannjjm 4831 7 days day NNS cord-023095-4dannjjm 4831 8 1 1 CD cord-023095-4dannjjm 4831 9 through through IN cord-023095-4dannjjm 4831 10 4 4 CD cord-023095-4dannjjm 4831 11 of of IN cord-023095-4dannjjm 4831 12 hospitalization hospitalization NN cord-023095-4dannjjm 4831 13 . . . cord-023095-4dannjjm 4832 1 The the DT cord-023095-4dannjjm 4832 2 second second JJ cord-023095-4dannjjm 4832 3 group group NN cord-023095-4dannjjm 4832 4 did do VBD cord-023095-4dannjjm 4832 5 not not RB cord-023095-4dannjjm 4832 6 receive receive VB cord-023095-4dannjjm 4832 7 LLLT LLLT NNP cord-023095-4dannjjm 4832 8 , , , cord-023095-4dannjjm 4832 9 but but CC cord-023095-4dannjjm 4832 10 followed follow VBD cord-023095-4dannjjm 4832 11 the the DT cord-023095-4dannjjm 4832 12 same same JJ cord-023095-4dannjjm 4832 13 peri peri JJ cord-023095-4dannjjm 4832 14 - - HYPH cord-023095-4dannjjm 4832 15 operative operative JJ cord-023095-4dannjjm 4832 16 medication medication NN cord-023095-4dannjjm 4832 17 protocol protocol NN cord-023095-4dannjjm 4832 18 . . . cord-023095-4dannjjm 4833 1 The the DT cord-023095-4dannjjm 4833 2 laser laser NN cord-023095-4dannjjm 4833 3 used use VBN cord-023095-4dannjjm 4833 4 in in IN cord-023095-4dannjjm 4833 5 this this DT cord-023095-4dannjjm 4833 6 study study NN cord-023095-4dannjjm 4833 7 was be VBD cord-023095-4dannjjm 4833 8 an an DT cord-023095-4dannjjm 4833 9 Erchonia Erchonia NNP cord-023095-4dannjjm 4833 10 laser laser NN cord-023095-4dannjjm 4833 11 model model NN cord-023095-4dannjjm 4833 12 PL5000 pl5000 NN cord-023095-4dannjjm 4833 13 ( ( -LRB- cord-023095-4dannjjm 4833 14 635 635 CD cord-023095-4dannjjm 4833 15 nm nm NN cord-023095-4dannjjm 4833 16 ) ) -RRB- cord-023095-4dannjjm 4833 17 . . . cord-023095-4dannjjm 4834 1 The the DT cord-023095-4dannjjm 4834 2 hertz hertz NNP cord-023095-4dannjjm 4834 3 setting set VBG cord-023095-4dannjjm 4834 4 was be VBD cord-023095-4dannjjm 4834 5 similar similar JJ cord-023095-4dannjjm 4834 6 for for IN cord-023095-4dannjjm 4834 7 each each DT cord-023095-4dannjjm 4834 8 patient patient NN cord-023095-4dannjjm 4834 9 using use VBG cord-023095-4dannjjm 4834 10 the the DT cord-023095-4dannjjm 4834 11 previously previously RB cord-023095-4dannjjm 4834 12 established establish VBN cord-023095-4dannjjm 4834 13 protocol protocol NN cord-023095-4dannjjm 4834 14 for for IN cord-023095-4dannjjm 4834 15 intervertebral intervertebral JJ cord-023095-4dannjjm 4834 16 disc disc NN cord-023095-4dannjjm 4834 17 disease disease NN cord-023095-4dannjjm 4834 18 ( ( -LRB- cord-023095-4dannjjm 4834 19 IVDD IVDD NNP cord-023095-4dannjjm 4834 20 ) ) -RRB- cord-023095-4dannjjm 4834 21 with with IN cord-023095-4dannjjm 4834 22 pulse pulse NN cord-023095-4dannjjm 4834 23 rate rate NN cord-023095-4dannjjm 4834 24 ranging range VBG cord-023095-4dannjjm 4834 25 from from IN cord-023095-4dannjjm 4834 26 9Hz 9hz CD cord-023095-4dannjjm 4834 27 to to IN cord-023095-4dannjjm 4834 28 1151 1151 CD cord-023095-4dannjjm 4834 29 Hz Hz NNP cord-023095-4dannjjm 4834 30 . . . cord-023095-4dannjjm 4835 1 All all DT cord-023095-4dannjjm 4835 2 dogs dog NNS cord-023095-4dannjjm 4835 3 received receive VBD cord-023095-4dannjjm 4835 4 advanced advanced JJ cord-023095-4dannjjm 4835 5 imaging imaging NN cord-023095-4dannjjm 4835 6 pre pre NN cord-023095-4dannjjm 4835 7 - - VBN cord-023095-4dannjjm 4835 8 operatively operatively RB cord-023095-4dannjjm 4835 9 with with IN cord-023095-4dannjjm 4835 10 myelogram myelogram NNP cord-023095-4dannjjm 4835 11 or or CC cord-023095-4dannjjm 4835 12 MRI MRI NNP cord-023095-4dannjjm 4835 13 . . . cord-023095-4dannjjm 4836 1 Results result NNS cord-023095-4dannjjm 4836 2 of of IN cord-023095-4dannjjm 4836 3 the the DT cord-023095-4dannjjm 4836 4 study study NN cord-023095-4dannjjm 4836 5 revealed reveal VBD cord-023095-4dannjjm 4836 6 that that IN cord-023095-4dannjjm 4836 7 treatment treatment NN cord-023095-4dannjjm 4836 8 with with IN cord-023095-4dannjjm 4836 9 LLLT LLLT NNP cord-023095-4dannjjm 4836 10 of of IN cord-023095-4dannjjm 4836 11 635 635 CD cord-023095-4dannjjm 4836 12 nm nm NN cord-023095-4dannjjm 4836 13 wavelength wavelength NN cord-023095-4dannjjm 4836 14 did do VBD cord-023095-4dannjjm 4836 15 not not RB cord-023095-4dannjjm 4836 16 shorten shorten VB cord-023095-4dannjjm 4836 17 or or CC cord-023095-4dannjjm 4836 18 improve improve VB cord-023095-4dannjjm 4836 19 recovery recovery NN cord-023095-4dannjjm 4836 20 times time NNS cord-023095-4dannjjm 4836 21 for for IN cord-023095-4dannjjm 4836 22 dogs dog NNS cord-023095-4dannjjm 4836 23 with with IN cord-023095-4dannjjm 4836 24 acute acute JJ cord-023095-4dannjjm 4836 25 onset onset NN cord-023095-4dannjjm 4836 26 paraplegia paraplegia NN cord-023095-4dannjjm 4836 27 secondary secondary JJ cord-023095-4dannjjm 4836 28 to to IN cord-023095-4dannjjm 4836 29 IVDD IVDD NNP cord-023095-4dannjjm 4836 30 after after IN cord-023095-4dannjjm 4836 31 hemilaminectomy hemilaminectomy NN cord-023095-4dannjjm 4836 32 procedures procedure NNS cord-023095-4dannjjm 4836 33 . . . cord-023095-4dannjjm 4837 1 Dogs dog NNS cord-023095-4dannjjm 4837 2 that that WDT cord-023095-4dannjjm 4837 3 showed show VBD cord-023095-4dannjjm 4837 4 recovery recovery NN cord-023095-4dannjjm 4837 5 to to IN cord-023095-4dannjjm 4837 6 ambulation ambulation NN cord-023095-4dannjjm 4837 7 at at IN cord-023095-4dannjjm 4837 8 the the DT cord-023095-4dannjjm 4837 9 two two CD cord-023095-4dannjjm 4837 10 week week NN cord-023095-4dannjjm 4837 11 recheck recheck NN cord-023095-4dannjjm 4837 12 were be VBD cord-023095-4dannjjm 4837 13 consistently consistently RB cord-023095-4dannjjm 4837 14 dogs dog NNS cord-023095-4dannjjm 4837 15 that that WDT cord-023095-4dannjjm 4837 16 were be VBD cord-023095-4dannjjm 4837 17 deep deep JJ cord-023095-4dannjjm 4837 18 pain pain NN cord-023095-4dannjjm 4837 19 positive positive JJ cord-023095-4dannjjm 4837 20 on on IN cord-023095-4dannjjm 4837 21 presentation presentation NN cord-023095-4dannjjm 4837 22 . . . cord-023095-4dannjjm 4838 1 A a DT cord-023095-4dannjjm 4838 2 lengthened lengthen VBN cord-023095-4dannjjm 4838 3 recovery recovery NN cord-023095-4dannjjm 4838 4 time time NN cord-023095-4dannjjm 4838 5 or or CC cord-023095-4dannjjm 4838 6 no no DT cord-023095-4dannjjm 4838 7 recovery recovery NN cord-023095-4dannjjm 4838 8 was be VBD cord-023095-4dannjjm 4838 9 seen see VBN cord-023095-4dannjjm 4838 10 in in IN cord-023095-4dannjjm 4838 11 the the DT cord-023095-4dannjjm 4838 12 majority majority NN cord-023095-4dannjjm 4838 13 of of IN cord-023095-4dannjjm 4838 14 those those DT cord-023095-4dannjjm 4838 15 dogs dog NNS cord-023095-4dannjjm 4838 16 with with IN cord-023095-4dannjjm 4838 17 absent absent JJ cord-023095-4dannjjm 4838 18 deep deep JJ cord-023095-4dannjjm 4838 19 pain pain NN cord-023095-4dannjjm 4838 20 on on IN cord-023095-4dannjjm 4838 21 presentation presentation NN cord-023095-4dannjjm 4838 22 as as IN cord-023095-4dannjjm 4838 23 has have VBZ cord-023095-4dannjjm 4838 24 been be VBN cord-023095-4dannjjm 4838 25 revealed reveal VBN cord-023095-4dannjjm 4838 26 historically historically RB cord-023095-4dannjjm 4838 27 in in IN cord-023095-4dannjjm 4838 28 past past JJ cord-023095-4dannjjm 4838 29 studies study NNS cord-023095-4dannjjm 4838 30 . . . cord-023095-4dannjjm 4839 1 LLLT LLLT NNP cord-023095-4dannjjm 4839 2 did do VBD cord-023095-4dannjjm 4839 3 not not RB cord-023095-4dannjjm 4839 4 appear appear VB cord-023095-4dannjjm 4839 5 to to TO cord-023095-4dannjjm 4839 6 have have VB cord-023095-4dannjjm 4839 7 an an DT cord-023095-4dannjjm 4839 8 effect effect NN cord-023095-4dannjjm 4839 9 on on IN cord-023095-4dannjjm 4839 10 this this DT cord-023095-4dannjjm 4839 11 result result NN cord-023095-4dannjjm 4839 12 . . . cord-023095-4dannjjm 4840 1 However however RB cord-023095-4dannjjm 4840 2 , , , cord-023095-4dannjjm 4840 3 there there EX cord-023095-4dannjjm 4840 4 are be VBP cord-023095-4dannjjm 4840 5 few few JJ cord-023095-4dannjjm 4840 6 data datum NNS cord-023095-4dannjjm 4840 7 describing describe VBG cord-023095-4dannjjm 4840 8 normal normal JJ cord-023095-4dannjjm 4840 9 glucose glucose NN cord-023095-4dannjjm 4840 10 uptake uptake NN cord-023095-4dannjjm 4840 11 of of IN cord-023095-4dannjjm 4840 12 the the DT cord-023095-4dannjjm 4840 13 canine canine JJ cord-023095-4dannjjm 4840 14 brain brain NN cord-023095-4dannjjm 4840 15 for for IN cord-023095-4dannjjm 4840 16 comparison comparison NN cord-023095-4dannjjm 4840 17 with with IN cord-023095-4dannjjm 4840 18 suspected suspect VBN cord-023095-4dannjjm 4840 19 or or CC cord-023095-4dannjjm 4840 20 confirmed confirm VBN cord-023095-4dannjjm 4840 21 disease disease NN cord-023095-4dannjjm 4840 22 . . . cord-023095-4dannjjm 4841 1 Thus thus RB cord-023095-4dannjjm 4841 2 the the DT cord-023095-4dannjjm 4841 3 purpose purpose NN cord-023095-4dannjjm 4841 4 of of IN cord-023095-4dannjjm 4841 5 this this DT cord-023095-4dannjjm 4841 6 study study NN cord-023095-4dannjjm 4841 7 was be VBD cord-023095-4dannjjm 4841 8 to to TO cord-023095-4dannjjm 4841 9 assess assess VB cord-023095-4dannjjm 4841 10 the the DT cord-023095-4dannjjm 4841 11 normal normal JJ cord-023095-4dannjjm 4841 12 distribution distribution NN cord-023095-4dannjjm 4841 13 of of IN cord-023095-4dannjjm 4841 14 FDG FDG NNP cord-023095-4dannjjm 4841 15 uptake uptake NN cord-023095-4dannjjm 4841 16 of of IN cord-023095-4dannjjm 4841 17 canine canine JJ cord-023095-4dannjjm 4841 18 brain brain NN cord-023095-4dannjjm 4841 19 structures structure NNS cord-023095-4dannjjm 4841 20 using use VBG cord-023095-4dannjjm 4841 21 a a DT cord-023095-4dannjjm 4841 22 high high JJ cord-023095-4dannjjm 4841 23 - - HYPH cord-023095-4dannjjm 4841 24 resolution resolution NN cord-023095-4dannjjm 4841 25 research research NN cord-023095-4dannjjm 4841 26 tomography tomography NN cord-023095-4dannjjm 4841 27 - - HYPH cord-023095-4dannjjm 4841 28 PET pet NN cord-023095-4dannjjm 4841 29 and and CC cord-023095-4dannjjm 4841 30 7 7 CD cord-023095-4dannjjm 4841 31 T t NN cord-023095-4dannjjm 4841 32 - - HYPH cord-023095-4dannjjm 4841 33 magnetic magnetic JJ cord-023095-4dannjjm 4841 34 resonance resonance NN cord-023095-4dannjjm 4841 35 imaging imaging NN cord-023095-4dannjjm 4841 36 ( ( -LRB- cord-023095-4dannjjm 4841 37 MRI MRI NNP cord-023095-4dannjjm 4841 38 ) ) -RRB- cord-023095-4dannjjm 4841 39 fusion fusion NN cord-023095-4dannjjm 4841 40 system system NN cord-023095-4dannjjm 4841 41 . . . cord-023095-4dannjjm 4842 1 FDG FDG NNP cord-023095-4dannjjm 4842 2 - - HYPH cord-023095-4dannjjm 4842 3 PET PET NNP cord-023095-4dannjjm 4842 4 and and CC cord-023095-4dannjjm 4842 5 T2-weighted t2-weighte VBD cord-023095-4dannjjm 4842 6 MR MR NNP cord-023095-4dannjjm 4842 7 imaging imaging NN cord-023095-4dannjjm 4842 8 of of IN cord-023095-4dannjjm 4842 9 the the DT cord-023095-4dannjjm 4842 10 brain brain NN cord-023095-4dannjjm 4842 11 were be VBD cord-023095-4dannjjm 4842 12 performed perform VBN cord-023095-4dannjjm 4842 13 on on IN cord-023095-4dannjjm 4842 14 4 4 CD cord-023095-4dannjjm 4842 15 healthy healthy JJ cord-023095-4dannjjm 4842 16 laboratory laboratory NN cord-023095-4dannjjm 4842 17 beagle beagle NN cord-023095-4dannjjm 4842 18 dogs dog NNS cord-023095-4dannjjm 4842 19 . . . cord-023095-4dannjjm 4843 1 Acquired acquire VBN cord-023095-4dannjjm 4843 2 PET PET NNP cord-023095-4dannjjm 4843 3 and and CC cord-023095-4dannjjm 4843 4 MR MR NNP cord-023095-4dannjjm 4843 5 images image NNS cord-023095-4dannjjm 4843 6 were be VBD cord-023095-4dannjjm 4843 7 automatically automatically RB cord-023095-4dannjjm 4843 8 co co JJ cord-023095-4dannjjm 4843 9 - - VBN cord-023095-4dannjjm 4843 10 registered register VBN cord-023095-4dannjjm 4843 11 by by IN cord-023095-4dannjjm 4843 12 the the DT cord-023095-4dannjjm 4843 13 image image NN cord-023095-4dannjjm 4843 14 analysis analysis NN cord-023095-4dannjjm 4843 15 software software NN cord-023095-4dannjjm 4843 16 . . . cord-023095-4dannjjm 4844 1 On on IN cord-023095-4dannjjm 4844 2 MR MR NNP cord-023095-4dannjjm 4844 3 images image NNS cord-023095-4dannjjm 4844 4 , , , cord-023095-4dannjjm 4844 5 regions region NNS cord-023095-4dannjjm 4844 6 of of IN cord-023095-4dannjjm 4844 7 interest interest NN cord-023095-4dannjjm 4844 8 ( ( -LRB- cord-023095-4dannjjm 4844 9 ROI ROI NNP cord-023095-4dannjjm 4844 10 ) ) -RRB- cord-023095-4dannjjm 4844 11 were be VBD cord-023095-4dannjjm 4844 12 manually manually RB cord-023095-4dannjjm 4844 13 drawn draw VBN cord-023095-4dannjjm 4844 14 over over IN cord-023095-4dannjjm 4844 15 48 48 CD cord-023095-4dannjjm 4844 16 intracranial intracranial JJ cord-023095-4dannjjm 4844 17 structures structure NNS cord-023095-4dannjjm 4844 18 , , , cord-023095-4dannjjm 4844 19 including include VBG cord-023095-4dannjjm 4844 20 6 6 CD cord-023095-4dannjjm 4844 21 gross gross JJ cord-023095-4dannjjm 4844 22 structures structure NNS cord-023095-4dannjjm 4844 23 ( ( -LRB- cord-023095-4dannjjm 4844 24 whole whole JJ cord-023095-4dannjjm 4844 25 brain brain NN cord-023095-4dannjjm 4844 26 , , , cord-023095-4dannjjm 4844 27 telencephalon telencephalon NNP cord-023095-4dannjjm 4844 28 , , , cord-023095-4dannjjm 4844 29 diencephalon diencephalon NNP cord-023095-4dannjjm 4844 30 , , , cord-023095-4dannjjm 4844 31 mesencephalon mesencephalon NNP cord-023095-4dannjjm 4844 32 , , , cord-023095-4dannjjm 4844 33 dorsal dorsal NNP cord-023095-4dannjjm 4844 34 metencephalon metencephalon NNP cord-023095-4dannjjm 4844 35 , , , cord-023095-4dannjjm 4844 36 ventral ventral NNP cord-023095-4dannjjm 4844 37 metencephalon metencephalon NNP cord-023095-4dannjjm 4844 38 and and CC cord-023095-4dannjjm 4844 39 myelencephalon myelencephalon NNP cord-023095-4dannjjm 4844 40 ) ) -RRB- cord-023095-4dannjjm 4844 41 . . . cord-023095-4dannjjm 4845 1 A a DT cord-023095-4dannjjm 4845 2 standard standard JJ cord-023095-4dannjjm 4845 3 uptake uptake NN cord-023095-4dannjjm 4845 4 value value NN cord-023095-4dannjjm 4845 5 ( ( -LRB- cord-023095-4dannjjm 4845 6 SUV SUV NNP cord-023095-4dannjjm 4845 7 ) ) -RRB- cord-023095-4dannjjm 4845 8 and and CC cord-023095-4dannjjm 4845 9 relative relative JJ cord-023095-4dannjjm 4845 10 SUV SUV NNP cord-023095-4dannjjm 4845 11 ratio ratio NN cord-023095-4dannjjm 4845 12 ( ( -LRB- cord-023095-4dannjjm 4845 13 rSUV rsuv RB cord-023095-4dannjjm 4845 14 5 5 CD cord-023095-4dannjjm 4845 15 SUV SUV NNP cord-023095-4dannjjm 4845 16 of of IN cord-023095-4dannjjm 4845 17 ROI ROI NNP cord-023095-4dannjjm 4845 18 / / SYM cord-023095-4dannjjm 4845 19 SUV SUV NNP cord-023095-4dannjjm 4845 20 of of IN cord-023095-4dannjjm 4845 21 whole whole JJ cord-023095-4dannjjm 4845 22 brain brain NN cord-023095-4dannjjm 4845 23 ) ) -RRB- cord-023095-4dannjjm 4845 24 were be VBD cord-023095-4dannjjm 4845 25 calculated calculate VBN cord-023095-4dannjjm 4845 26 for for IN cord-023095-4dannjjm 4845 27 each each DT cord-023095-4dannjjm 4845 28 ROI ROI NNP cord-023095-4dannjjm 4845 29 . . . cord-023095-4dannjjm 4846 1 7 7 CD cord-023095-4dannjjm 4846 2 T T NNP cord-023095-4dannjjm 4846 3 - - HYPH cord-023095-4dannjjm 4846 4 MR MR NNP cord-023095-4dannjjm 4846 5 images image NNS cord-023095-4dannjjm 4846 6 compensated compensate VBD cord-023095-4dannjjm 4846 7 the the DT cord-023095-4dannjjm 4846 8 low low JJ cord-023095-4dannjjm 4846 9 anatomical anatomical JJ cord-023095-4dannjjm 4846 10 resolution resolution NN cord-023095-4dannjjm 4846 11 of of IN cord-023095-4dannjjm 4846 12 PET PET NNP cord-023095-4dannjjm 4846 13 QJ;by QJ;by NNP cord-023095-4dannjjm 4846 14 proving prove VBG cord-023095-4dannjjm 4846 15 good good JJ cord-023095-4dannjjm 4846 16 spatial spatial JJ cord-023095-4dannjjm 4846 17 and and CC cord-023095-4dannjjm 4846 18 contrast contrast JJ cord-023095-4dannjjm 4846 19 resolution resolution NN cord-023095-4dannjjm 4846 20 for for IN cord-023095-4dannjjm 4846 21 the the DT cord-023095-4dannjjm 4846 22 identification identification NN cord-023095-4dannjjm 4846 23 of of IN cord-023095-4dannjjm 4846 24 the the DT cord-023095-4dannjjm 4846 25 clinically clinically RB cord-023095-4dannjjm 4846 26 relevant relevant JJ cord-023095-4dannjjm 4846 27 brain brain NN cord-023095-4dannjjm 4846 28 anatomy anatomy NN cord-023095-4dannjjm 4846 29 . . . cord-023095-4dannjjm 4847 1 Among among IN cord-023095-4dannjjm 4847 2 gross gross JJ cord-023095-4dannjjm 4847 3 structures structure NNS cord-023095-4dannjjm 4847 4 , , , cord-023095-4dannjjm 4847 5 mesencephalon mesencephalon NN cord-023095-4dannjjm 4847 6 and and CC cord-023095-4dannjjm 4847 7 ventral ventral NNP cord-023095-4dannjjm 4847 8 metencephalon metencephalon NNP cord-023095-4dannjjm 4847 9 had have VBD cord-023095-4dannjjm 4847 10 the the DT cord-023095-4dannjjm 4847 11 highest high JJS cord-023095-4dannjjm 4847 12 ( ( -LRB- cord-023095-4dannjjm 4847 13 SUV SUV NNP cord-023095-4dannjjm 4847 14 : : : cord-023095-4dannjjm 4847 15 4.17 4.17 CD cord-023095-4dannjjm 4847 16 AE AE NNP cord-023095-4dannjjm 4847 17 0.23 0.23 CD cord-023095-4dannjjm 4847 18 ; ; : cord-023095-4dannjjm 4847 19 rSUV rSUV NNP cord-023095-4dannjjm 4847 20 : : : cord-023095-4dannjjm 4847 21 1.12 1.12 CD cord-023095-4dannjjm 4847 22 AE AE NNP cord-023095-4dannjjm 4847 23 0.03 0.03 CD cord-023095-4dannjjm 4847 24 ) ) -RRB- cord-023095-4dannjjm 4847 25 and and CC cord-023095-4dannjjm 4847 26 the the DT cord-023095-4dannjjm 4847 27 lowest low JJS cord-023095-4dannjjm 4847 28 ( ( -LRB- cord-023095-4dannjjm 4847 29 SUV SUV NNP cord-023095-4dannjjm 4847 30 : : : cord-023095-4dannjjm 4847 31 3.34 3.34 CD cord-023095-4dannjjm 4847 32 AE AE NNP cord-023095-4dannjjm 4847 33 0.35 0.35 CD cord-023095-4dannjjm 4847 34 ; ; : cord-023095-4dannjjm 4847 35 rSUV rSUV NNP cord-023095-4dannjjm 4847 36 : : : cord-023095-4dannjjm 4847 37 0.90 0.90 CD cord-023095-4dannjjm 4847 38 AE AE NNP cord-023095-4dannjjm 4847 39 0.06 0.06 CD cord-023095-4dannjjm 4847 40 ) ) -RRB- cord-023095-4dannjjm 4848 1 FDG FDG NNP cord-023095-4dannjjm 4848 2 uptake uptake NN cord-023095-4dannjjm 4848 3 respectively respectively RB cord-023095-4dannjjm 4848 4 . . . cord-023095-4dannjjm 4849 1 When when WRB cord-023095-4dannjjm 4849 2 SUVs suv NNS cord-023095-4dannjjm 4849 3 were be VBD cord-023095-4dannjjm 4849 4 calculated calculate VBN cord-023095-4dannjjm 4849 5 on on IN cord-023095-4dannjjm 4849 6 42 42 CD cord-023095-4dannjjm 4849 7 detailed detailed JJ cord-023095-4dannjjm 4849 8 regions region NNS cord-023095-4dannjjm 4849 9 , , , cord-023095-4dannjjm 4849 10 rostral rostral NNP cord-023095-4dannjjm 4849 11 colliculus colliculus NNP cord-023095-4dannjjm 4849 12 and and CC cord-023095-4dannjjm 4849 13 corpus corpus NNP cord-023095-4dannjjm 4849 14 callosum callosum NNP cord-023095-4dannjjm 4849 15 had have VBD cord-023095-4dannjjm 4849 16 the the DT cord-023095-4dannjjm 4849 17 highest high JJS cord-023095-4dannjjm 4849 18 ( ( -LRB- cord-023095-4dannjjm 4849 19 SUV SUV NNP cord-023095-4dannjjm 4849 20 : : : cord-023095-4dannjjm 4849 21 6.00 6.00 CD cord-023095-4dannjjm 4849 22 AE AE NNP cord-023095-4dannjjm 4849 23 0.16 0.16 CD cord-023095-4dannjjm 4849 24 ; ; : cord-023095-4dannjjm 4849 25 rSUV rsuv JJ cord-023095-4dannjjm 4849 26 : : : cord-023095-4dannjjm 4849 27 1.62 1.62 CD cord-023095-4dannjjm 4849 28 AE AE NNP cord-023095-4dannjjm 4849 29 0.05 0.05 CD cord-023095-4dannjjm 4849 30 ) ) -RRB- cord-023095-4dannjjm 4849 31 and and CC cord-023095-4dannjjm 4849 32 the the DT cord-023095-4dannjjm 4849 33 lowest low JJS cord-023095-4dannjjm 4849 34 ( ( -LRB- cord-023095-4dannjjm 4849 35 SUV SUV NNP cord-023095-4dannjjm 4849 36 : : : cord-023095-4dannjjm 4849 37 2.81 2.81 CD cord-023095-4dannjjm 4849 38 AE AE NNP cord-023095-4dannjjm 4849 39 0.12 0.12 CD cord-023095-4dannjjm 4849 40 ; ; : cord-023095-4dannjjm 4849 41 rSUV rSUV NNP cord-023095-4dannjjm 4849 42 : : : cord-023095-4dannjjm 4849 43 0.76 0.76 CD cord-023095-4dannjjm 4849 44 AE AE NNP cord-023095-4dannjjm 4849 45 0.06 0.06 CD cord-023095-4dannjjm 4849 46 ) ) -RRB- cord-023095-4dannjjm 4849 47 value value NN cord-023095-4dannjjm 4849 48 respectively respectively RB cord-023095-4dannjjm 4849 49 . . . cord-023095-4dannjjm 4850 1 These these DT cord-023095-4dannjjm 4850 2 data datum NNS cord-023095-4dannjjm 4850 3 acquired acquire VBD cord-023095-4dannjjm 4850 4 from from IN cord-023095-4dannjjm 4850 5 normal normal JJ cord-023095-4dannjjm 4850 6 dog dog NN cord-023095-4dannjjm 4850 7 brain brain NN cord-023095-4dannjjm 4850 8 will will MD cord-023095-4dannjjm 4850 9 be be VB cord-023095-4dannjjm 4850 10 used use VBN cord-023095-4dannjjm 4850 11 in in IN cord-023095-4dannjjm 4850 12 clinical clinical JJ cord-023095-4dannjjm 4850 13 neurology neurology NN cord-023095-4dannjjm 4850 14 to to TO cord-023095-4dannjjm 4850 15 investigate investigate VB cord-023095-4dannjjm 4850 16 various various JJ cord-023095-4dannjjm 4850 17 intracranial intracranial JJ cord-023095-4dannjjm 4850 18 diseases disease NNS cord-023095-4dannjjm 4850 19 such such JJ cord-023095-4dannjjm 4850 20 as as IN cord-023095-4dannjjm 4850 21 inflammation inflammation NN cord-023095-4dannjjm 4850 22 , , , cord-023095-4dannjjm 4850 23 neoplasm neoplasm NN cord-023095-4dannjjm 4850 24 and and CC cord-023095-4dannjjm 4850 25 behavioral behavioral JJ cord-023095-4dannjjm 4850 26 disorders disorder NNS cord-023095-4dannjjm 4850 27 . . . cord-023095-4dannjjm 4851 1 Degenerative degenerative JJ cord-023095-4dannjjm 4851 2 lumbosacral lumbosacral JJ cord-023095-4dannjjm 4851 3 stenosis stenosis NN cord-023095-4dannjjm 4851 4 ( ( -LRB- cord-023095-4dannjjm 4851 5 DLSS DLSS NNP cord-023095-4dannjjm 4851 6 ) ) -RRB- cord-023095-4dannjjm 4851 7 is be VBZ cord-023095-4dannjjm 4851 8 a a DT cord-023095-4dannjjm 4851 9 multifactorial multifactorial JJ cord-023095-4dannjjm 4851 10 condition condition NN cord-023095-4dannjjm 4851 11 affecting affect VBG cord-023095-4dannjjm 4851 12 predominantly predominantly RB cord-023095-4dannjjm 4851 13 large large JJ cord-023095-4dannjjm 4851 14 breed breed NN cord-023095-4dannjjm 4851 15 dogs dog NNS cord-023095-4dannjjm 4851 16 . . . cord-023095-4dannjjm 4852 1 The the DT cord-023095-4dannjjm 4852 2 combination combination NN cord-023095-4dannjjm 4852 3 of of IN cord-023095-4dannjjm 4852 4 stenosis stenosis NN cord-023095-4dannjjm 4852 5 and and CC cord-023095-4dannjjm 4852 6 compressive compressive JJ cord-023095-4dannjjm 4852 7 neuropathy neuropathy NN cord-023095-4dannjjm 4852 8 cause cause VB cord-023095-4dannjjm 4852 9 lumbar lumbar JJ cord-023095-4dannjjm 4852 10 pain pain NN cord-023095-4dannjjm 4852 11 , , , cord-023095-4dannjjm 4852 12 lameness lameness NN cord-023095-4dannjjm 4852 13 and and CC cord-023095-4dannjjm 4852 14 neurologic neurologic JJ cord-023095-4dannjjm 4852 15 dysfunction dysfunction NN cord-023095-4dannjjm 4852 16 . . . cord-023095-4dannjjm 4853 1 Previous previous JJ cord-023095-4dannjjm 4853 2 reports report NNS cord-023095-4dannjjm 4853 3 describe describe VBP cord-023095-4dannjjm 4853 4 urinary urinary JJ cord-023095-4dannjjm 4853 5 and and CC cord-023095-4dannjjm 4853 6 fecal fecal JJ cord-023095-4dannjjm 4853 7 incontinence incontinence NN cord-023095-4dannjjm 4853 8 in in IN cord-023095-4dannjjm 4853 9 severely severely RB cord-023095-4dannjjm 4853 10 affected affect VBN cord-023095-4dannjjm 4853 11 dogs dog NNS cord-023095-4dannjjm 4853 12 . . . cord-023095-4dannjjm 4854 1 The the DT cord-023095-4dannjjm 4854 2 objectives objective NNS cord-023095-4dannjjm 4854 3 of of IN cord-023095-4dannjjm 4854 4 this this DT cord-023095-4dannjjm 4854 5 retrospective retrospective JJ cord-023095-4dannjjm 4854 6 case case NN cord-023095-4dannjjm 4854 7 series series NN cord-023095-4dannjjm 4854 8 were be VBD cord-023095-4dannjjm 4854 9 to to TO cord-023095-4dannjjm 4854 10 describe describe VB cord-023095-4dannjjm 4854 11 the the DT cord-023095-4dannjjm 4854 12 clinical clinical JJ cord-023095-4dannjjm 4854 13 signs sign NNS cord-023095-4dannjjm 4854 14 associated associate VBN cord-023095-4dannjjm 4854 15 with with IN cord-023095-4dannjjm 4854 16 dysuria dysuria NNS cord-023095-4dannjjm 4854 17 and and CC cord-023095-4dannjjm 4854 18 eventual eventual JJ cord-023095-4dannjjm 4854 19 diagnosis diagnosis NN cord-023095-4dannjjm 4854 20 of of IN cord-023095-4dannjjm 4854 21 DLSS dls NNS cord-023095-4dannjjm 4854 22 in in IN cord-023095-4dannjjm 4854 23 dogs dog NNS cord-023095-4dannjjm 4854 24 , , , cord-023095-4dannjjm 4854 25 and and CC cord-023095-4dannjjm 4854 26 to to TO cord-023095-4dannjjm 4854 27 describe describe VB cord-023095-4dannjjm 4854 28 factors factor NNS cord-023095-4dannjjm 4854 29 associated associate VBN cord-023095-4dannjjm 4854 30 with with IN cord-023095-4dannjjm 4854 31 regained regained JJ cord-023095-4dannjjm 4854 32 micturition micturition NN cord-023095-4dannjjm 4854 33 following follow VBG cord-023095-4dannjjm 4854 34 prompt prompt JJ cord-023095-4dannjjm 4854 35 diagnosis diagnosis NN cord-023095-4dannjjm 4854 36 and and CC cord-023095-4dannjjm 4854 37 treatment treatment NN cord-023095-4dannjjm 4854 38 . . . cord-023095-4dannjjm 4855 1 Medical medical JJ cord-023095-4dannjjm 4855 2 records record NNS cord-023095-4dannjjm 4855 3 from from IN cord-023095-4dannjjm 4855 4 the the DT cord-023095-4dannjjm 4855 5 University University NNP cord-023095-4dannjjm 4855 6 of of IN cord-023095-4dannjjm 4855 7 Georgia Georgia NNP cord-023095-4dannjjm 4855 8 and and CC cord-023095-4dannjjm 4855 9 the the DT cord-023095-4dannjjm 4855 10 University University NNP cord-023095-4dannjjm 4855 11 of of IN cord-023095-4dannjjm 4855 12 Missouri Missouri NNP cord-023095-4dannjjm 4855 13 between between IN cord-023095-4dannjjm 4855 14 1995 1995 CD cord-023095-4dannjjm 4855 15 and and CC cord-023095-4dannjjm 4855 16 2009 2009 CD cord-023095-4dannjjm 4855 17 of of IN cord-023095-4dannjjm 4855 18 11 11 CD cord-023095-4dannjjm 4855 19 dogs dog NNS cord-023095-4dannjjm 4855 20 were be VBD cord-023095-4dannjjm 4855 21 reviewed review VBN cord-023095-4dannjjm 4855 22 . . . cord-023095-4dannjjm 4856 1 Inclusion inclusion NN cord-023095-4dannjjm 4856 2 required require VBN cord-023095-4dannjjm 4856 3 observation observation NN cord-023095-4dannjjm 4856 4 of of IN cord-023095-4dannjjm 4856 5 dysuria dysuria NNP cord-023095-4dannjjm 4856 6 , , , cord-023095-4dannjjm 4856 7 urine urine NN cord-023095-4dannjjm 4856 8 retention retention NN cord-023095-4dannjjm 4856 9 , , , cord-023095-4dannjjm 4856 10 absence absence NN cord-023095-4dannjjm 4856 11 of of IN cord-023095-4dannjjm 4856 12 structural structural JJ cord-023095-4dannjjm 4856 13 lower low JJR cord-023095-4dannjjm 4856 14 urinary urinary JJ cord-023095-4dannjjm 4856 15 tract tract NN cord-023095-4dannjjm 4856 16 disease disease NN cord-023095-4dannjjm 4856 17 and and CC cord-023095-4dannjjm 4856 18 concurrent concurrent JJ cord-023095-4dannjjm 4856 19 presumptive presumptive JJ cord-023095-4dannjjm 4856 20 diagnosis diagnosis NN cord-023095-4dannjjm 4856 21 of of IN cord-023095-4dannjjm 4856 22 DLSS DLSS NNP cord-023095-4dannjjm 4856 23 . . . cord-023095-4dannjjm 4857 1 Dysuria Dysuria NNP cord-023095-4dannjjm 4857 2 was be VBD cord-023095-4dannjjm 4857 3 defined define VBN cord-023095-4dannjjm 4857 4 as as IN cord-023095-4dannjjm 4857 5 inability inability NN cord-023095-4dannjjm 4857 6 to to TO cord-023095-4dannjjm 4857 7 initiate initiate VB cord-023095-4dannjjm 4857 8 or or CC cord-023095-4dannjjm 4857 9 sustain sustain VB cord-023095-4dannjjm 4857 10 a a DT cord-023095-4dannjjm 4857 11 urine urine NN cord-023095-4dannjjm 4857 12 stream stream NN cord-023095-4dannjjm 4857 13 . . . cord-023095-4dannjjm 4858 1 Urine urine NN cord-023095-4dannjjm 4858 2 residual residual JJ cord-023095-4dannjjm 4858 3 volume volume NN cord-023095-4dannjjm 4858 4 was be VBD cord-023095-4dannjjm 4858 5 evaluated evaluate VBN cord-023095-4dannjjm 4858 6 postvoiding postvoide VBG cord-023095-4dannjjm 4858 7 . . . cord-023095-4dannjjm 4859 1 Dysuria Dysuria NNP cord-023095-4dannjjm 4859 2 was be VBD cord-023095-4dannjjm 4859 3 further further RB cord-023095-4dannjjm 4859 4 evaluated evaluate VBN cord-023095-4dannjjm 4859 5 using use VBG cord-023095-4dannjjm 4859 6 urethral urethral JJ cord-023095-4dannjjm 4859 7 contrast contrast NN cord-023095-4dannjjm 4859 8 studies study NNS cord-023095-4dannjjm 4859 9 , , , cord-023095-4dannjjm 4859 10 urodynamic urodynamic JJ cord-023095-4dannjjm 4859 11 testing testing NN cord-023095-4dannjjm 4859 12 ( ( -LRB- cord-023095-4dannjjm 4859 13 urethral urethral NNP cord-023095-4dannjjm 4859 14 profilometry profilometry NNP cord-023095-4dannjjm 4859 15 ( ( -LRB- cord-023095-4dannjjm 4859 16 4 4 CD cord-023095-4dannjjm 4859 17 ) ) -RRB- cord-023095-4dannjjm 4859 18 and and CC cord-023095-4dannjjm 4859 19 cystometry cystometry NNP cord-023095-4dannjjm 4859 20 ( ( -LRB- cord-023095-4dannjjm 4859 21 4 4 CD cord-023095-4dannjjm 4859 22 ) ) -RRB- cord-023095-4dannjjm 4859 23 ) ) -RRB- cord-023095-4dannjjm 4859 24 , , , cord-023095-4dannjjm 4859 25 ultrasonography ultrasonography NN cord-023095-4dannjjm 4859 26 ( ( -LRB- cord-023095-4dannjjm 4859 27 5 5 CD cord-023095-4dannjjm 4859 28 ) ) -RRB- cord-023095-4dannjjm 4859 29 , , , cord-023095-4dannjjm 4859 30 and and CC cord-023095-4dannjjm 4859 31 urine urine NN cord-023095-4dannjjm 4859 32 culture culture NN cord-023095-4dannjjm 4859 33 ( ( -LRB- cord-023095-4dannjjm 4859 34 8) 8) NN cord-023095-4dannjjm 4859 35 . . . cord-023095-4dannjjm 4860 1 Presumptive presumptive JJ cord-023095-4dannjjm 4860 2 diagnosis diagnosis NN cord-023095-4dannjjm 4860 3 of of IN cord-023095-4dannjjm 4860 4 DLSS DLSS NNP cord-023095-4dannjjm 4860 5 was be VBD cord-023095-4dannjjm 4860 6 based base VBN cord-023095-4dannjjm 4860 7 on on IN cord-023095-4dannjjm 4860 8 imaging image VBG cord-023095-4dannjjm 4860 9 using use VBG cord-023095-4dannjjm 4860 10 plain plain JJ cord-023095-4dannjjm 4860 11 radiography radiography NN cord-023095-4dannjjm 4860 12 and and CC cord-023095-4dannjjm 4860 13 epidurography epidurography NN cord-023095-4dannjjm 4860 14 ( ( -LRB- cord-023095-4dannjjm 4860 15 8) 8) NNP cord-023095-4dannjjm 4860 16 , , , cord-023095-4dannjjm 4860 17 computed compute VBN cord-023095-4dannjjm 4860 18 tomography tomography NN cord-023095-4dannjjm 4860 19 ( ( -LRB- cord-023095-4dannjjm 4860 20 1 1 CD cord-023095-4dannjjm 4860 21 ) ) -RRB- cord-023095-4dannjjm 4860 22 or or CC cord-023095-4dannjjm 4860 23 magnetic magnetic JJ cord-023095-4dannjjm 4860 24 resonance resonance NN cord-023095-4dannjjm 4860 25 imaging imaging NN cord-023095-4dannjjm 4860 26 ( ( -LRB- cord-023095-4dannjjm 4860 27 2 2 CD cord-023095-4dannjjm 4860 28 ) ) -RRB- cord-023095-4dannjjm 4860 29 . . . cord-023095-4dannjjm 4861 1 Breeds breed NNS cord-023095-4dannjjm 4861 2 represented represent VBN cord-023095-4dannjjm 4861 3 included include VBD cord-023095-4dannjjm 4861 4 the the DT cord-023095-4dannjjm 4861 5 German german JJ cord-023095-4dannjjm 4861 6 Shepherd Shepherd NNP cord-023095-4dannjjm 4861 7 Dog Dog NNP cord-023095-4dannjjm 4861 8 ( ( -LRB- cord-023095-4dannjjm 4861 9 n n NN cord-023095-4dannjjm 4861 10 5 5 CD cord-023095-4dannjjm 4861 11 3 3 CD cord-023095-4dannjjm 4861 12 ) ) -RRB- cord-023095-4dannjjm 4861 13 , , , cord-023095-4dannjjm 4861 14 Golden Golden NNP cord-023095-4dannjjm 4861 15 Retriever Retriever NNP cord-023095-4dannjjm 4861 16 ( ( -LRB- cord-023095-4dannjjm 4861 17 n n NN cord-023095-4dannjjm 4861 18 5 5 CD cord-023095-4dannjjm 4861 19 2 2 CD cord-023095-4dannjjm 4861 20 ) ) -RRB- cord-023095-4dannjjm 4861 21 , , , cord-023095-4dannjjm 4861 22 Burnese Burnese NNP cord-023095-4dannjjm 4861 23 Mountain Mountain NNP cord-023095-4dannjjm 4861 24 Dog Dog NNP cord-023095-4dannjjm 4861 25 ( ( -LRB- cord-023095-4dannjjm 4861 26 n n NN cord-023095-4dannjjm 4861 27 5 5 CD cord-023095-4dannjjm 4861 28 2 2 CD cord-023095-4dannjjm 4861 29 ) ) -RRB- cord-023095-4dannjjm 4861 30 , , , cord-023095-4dannjjm 4861 31 and and CC cord-023095-4dannjjm 4861 32 1 1 CD cord-023095-4dannjjm 4861 33 each each DT cord-023095-4dannjjm 4861 34 Labrador Labrador NNP cord-023095-4dannjjm 4861 35 Retriever Retriever NNP cord-023095-4dannjjm 4861 36 , , , cord-023095-4dannjjm 4861 37 Weimaraner Weimaraner NNP cord-023095-4dannjjm 4861 38 , , , cord-023095-4dannjjm 4861 39 Rottweiler Rottweiler NNP cord-023095-4dannjjm 4861 40 and and CC cord-023095-4dannjjm 4861 41 mixed mix VBN cord-023095-4dannjjm 4861 42 - - HYPH cord-023095-4dannjjm 4861 43 breed breed NN cord-023095-4dannjjm 4861 44 . . . cord-023095-4dannjjm 4862 1 All all DT cord-023095-4dannjjm 4862 2 dogs dog NNS cord-023095-4dannjjm 4862 3 were be VBD cord-023095-4dannjjm 4862 4 male male JJ cord-023095-4dannjjm 4862 5 . . . cord-023095-4dannjjm 4863 1 8 8 CD cord-023095-4dannjjm 4863 2 were be VBD cord-023095-4dannjjm 4863 3 intact intact JJ cord-023095-4dannjjm 4863 4 at at IN cord-023095-4dannjjm 4863 5 onset onset NN cord-023095-4dannjjm 4863 6 of of IN cord-023095-4dannjjm 4863 7 clinical clinical JJ cord-023095-4dannjjm 4863 8 signs sign NNS cord-023095-4dannjjm 4863 9 . . . cord-023095-4dannjjm 4864 1 Median median JJ cord-023095-4dannjjm 4864 2 body body NN cord-023095-4dannjjm 4864 3 weight weight NN cord-023095-4dannjjm 4864 4 was be VBD cord-023095-4dannjjm 4864 5 38.5 38.5 CD cord-023095-4dannjjm 4864 6 kg kg NNS cord-023095-4dannjjm 4864 7 ( ( -LRB- cord-023095-4dannjjm 4864 8 range range VBP cord-023095-4dannjjm 4864 9 29.5 29.5 CD cord-023095-4dannjjm 4864 10 - - SYM cord-023095-4dannjjm 4864 11 46 46 CD cord-023095-4dannjjm 4864 12 ) ) -RRB- cord-023095-4dannjjm 4864 13 and and CC cord-023095-4dannjjm 4864 14 median median JJ cord-023095-4dannjjm 4864 15 age age NN cord-023095-4dannjjm 4864 16 was be VBD cord-023095-4dannjjm 4864 17 5 5 CD cord-023095-4dannjjm 4864 18 years year NNS cord-023095-4dannjjm 4864 19 ( ( -LRB- cord-023095-4dannjjm 4864 20 range range VBP cord-023095-4dannjjm 4864 21 2 2 CD cord-023095-4dannjjm 4864 22 - - SYM cord-023095-4dannjjm 4864 23 10 10 CD cord-023095-4dannjjm 4864 24 ) ) -RRB- cord-023095-4dannjjm 4864 25 . . . cord-023095-4dannjjm 4865 1 Median median JJ cord-023095-4dannjjm 4865 2 duration duration NN cord-023095-4dannjjm 4865 3 of of IN cord-023095-4dannjjm 4865 4 clinical clinical JJ cord-023095-4dannjjm 4865 5 signs sign NNS cord-023095-4dannjjm 4865 6 prior prior RB cord-023095-4dannjjm 4865 7 to to IN cord-023095-4dannjjm 4865 8 admission admission NN cord-023095-4dannjjm 4865 9 was be VBD cord-023095-4dannjjm 4865 10 2 2 CD cord-023095-4dannjjm 4865 11 months month NNS cord-023095-4dannjjm 4865 12 ( ( -LRB- cord-023095-4dannjjm 4865 13 range range VBP cord-023095-4dannjjm 4865 14 0.25 0.25 CD cord-023095-4dannjjm 4865 15 - - SYM cord-023095-4dannjjm 4865 16 12 12 CD cord-023095-4dannjjm 4865 17 ) ) -RRB- cord-023095-4dannjjm 4865 18 . . . cord-023095-4dannjjm 4866 1 Other other JJ cord-023095-4dannjjm 4866 2 pertinent pertinent JJ cord-023095-4dannjjm 4866 3 presenting present VBG cord-023095-4dannjjm 4866 4 clinical clinical JJ cord-023095-4dannjjm 4866 5 signs sign NNS cord-023095-4dannjjm 4866 6 included include VBD cord-023095-4dannjjm 4866 7 dyschezia dyschezia NNP cord-023095-4dannjjm 4866 8 ( ( -LRB- cord-023095-4dannjjm 4866 9 2 2 CD cord-023095-4dannjjm 4866 10 ) ) -RRB- cord-023095-4dannjjm 4866 11 , , , cord-023095-4dannjjm 4866 12 fecal fecal JJ cord-023095-4dannjjm 4866 13 incontinence incontinence NN cord-023095-4dannjjm 4866 14 ( ( -LRB- cord-023095-4dannjjm 4866 15 4 4 CD cord-023095-4dannjjm 4866 16 ) ) -RRB- cord-023095-4dannjjm 4866 17 , , , cord-023095-4dannjjm 4866 18 general general JJ cord-023095-4dannjjm 4866 19 proprioceptive proprioceptive JJ cord-023095-4dannjjm 4866 20 ataxia ataxia NN cord-023095-4dannjjm 4866 21 ( ( -LRB- cord-023095-4dannjjm 4866 22 2 2 CD cord-023095-4dannjjm 4866 23 ) ) -RRB- cord-023095-4dannjjm 4866 24 , , , cord-023095-4dannjjm 4866 25 weakness weakness NN cord-023095-4dannjjm 4866 26 ( ( -LRB- cord-023095-4dannjjm 4866 27 2 2 CD cord-023095-4dannjjm 4866 28 ) ) -RRB- cord-023095-4dannjjm 4866 29 , , , cord-023095-4dannjjm 4866 30 and and CC cord-023095-4dannjjm 4866 31 difficulty difficulty NN cord-023095-4dannjjm 4866 32 rising rise VBG cord-023095-4dannjjm 4866 33 ( ( -LRB- cord-023095-4dannjjm 4866 34 1 1 CD cord-023095-4dannjjm 4866 35 ) ) -RRB- cord-023095-4dannjjm 4866 36 . . . cord-023095-4dannjjm 4867 1 Physical physical JJ cord-023095-4dannjjm 4867 2 examination examination NN cord-023095-4dannjjm 4867 3 findings finding NNS cord-023095-4dannjjm 4867 4 included include VBD cord-023095-4dannjjm 4867 5 pelvic pelvic JJ cord-023095-4dannjjm 4867 6 limb limb NN cord-023095-4dannjjm 4867 7 muscle muscle NN cord-023095-4dannjjm 4867 8 atrophy atrophy NN cord-023095-4dannjjm 4867 9 ( ( -LRB- cord-023095-4dannjjm 4867 10 2 2 CD cord-023095-4dannjjm 4867 11 ) ) -RRB- cord-023095-4dannjjm 4867 12 and and CC cord-023095-4dannjjm 4867 13 prostatomegaly prostatomegaly NNP cord-023095-4dannjjm 4867 14 ( ( -LRB- cord-023095-4dannjjm 4867 15 1 1 CD cord-023095-4dannjjm 4867 16 ) ) -RRB- cord-023095-4dannjjm 4867 17 . . . cord-023095-4dannjjm 4868 1 Abnormal abnormal JJ cord-023095-4dannjjm 4868 2 neurologic neurologic JJ cord-023095-4dannjjm 4868 3 examination examination NN cord-023095-4dannjjm 4868 4 findings finding NNS cord-023095-4dannjjm 4868 5 included include VBD cord-023095-4dannjjm 4868 6 postural postural JJ cord-023095-4dannjjm 4868 7 reaction reaction NN cord-023095-4dannjjm 4868 8 deficits deficit NNS cord-023095-4dannjjm 4868 9 ( ( -LRB- cord-023095-4dannjjm 4868 10 6 6 CD cord-023095-4dannjjm 4868 11 ) ) -RRB- cord-023095-4dannjjm 4868 12 , , , cord-023095-4dannjjm 4868 13 hyporeflexia hyporeflexia NNP cord-023095-4dannjjm 4868 14 ( ( -LRB- cord-023095-4dannjjm 4868 15 4 4 CD cord-023095-4dannjjm 4868 16 ) ) -RRB- cord-023095-4dannjjm 4868 17 , , , cord-023095-4dannjjm 4868 18 decreased decrease VBD cord-023095-4dannjjm 4868 19 tail tail NN cord-023095-4dannjjm 4868 20 tone tone NN cord-023095-4dannjjm 4868 21 ( ( -LRB- cord-023095-4dannjjm 4868 22 3 3 CD cord-023095-4dannjjm 4868 23 ) ) -RRB- cord-023095-4dannjjm 4868 24 and and CC cord-023095-4dannjjm 4868 25 lumbosacral lumbosacral NNP cord-023095-4dannjjm 4868 26 hyperesthesia hyperesthesia NNP cord-023095-4dannjjm 4868 27 ( ( -LRB- cord-023095-4dannjjm 4868 28 6 6 CD cord-023095-4dannjjm 4868 29 ) ) -RRB- cord-023095-4dannjjm 4868 30 . . . cord-023095-4dannjjm 4869 1 Neurologic neurologic JJ cord-023095-4dannjjm 4869 2 examination examination NN cord-023095-4dannjjm 4869 3 was be VBD cord-023095-4dannjjm 4869 4 normal normal JJ cord-023095-4dannjjm 4869 5 in in IN cord-023095-4dannjjm 4869 6 3 3 CD cord-023095-4dannjjm 4869 7 dogs dog NNS cord-023095-4dannjjm 4869 8 . . . cord-023095-4dannjjm 4870 1 Dorsal dorsal JJ cord-023095-4dannjjm 4870 2 laminectomy laminectomy NN cord-023095-4dannjjm 4870 3 was be VBD cord-023095-4dannjjm 4870 4 performed perform VBN cord-023095-4dannjjm 4870 5 and and CC cord-023095-4dannjjm 4870 6 diagnosis diagnosis NN cord-023095-4dannjjm 4870 7 confirmed confirm VBD cord-023095-4dannjjm 4870 8 in in IN cord-023095-4dannjjm 4870 9 9 9 CD cord-023095-4dannjjm 4870 10 dogs dog NNS cord-023095-4dannjjm 4870 11 ; ; : cord-023095-4dannjjm 4870 12 recovery recovery NN cord-023095-4dannjjm 4870 13 was be VBD cord-023095-4dannjjm 4870 14 monitored monitor VBN cord-023095-4dannjjm 4870 15 for for IN cord-023095-4dannjjm 4870 16 a a DT cord-023095-4dannjjm 4870 17 median median NN cord-023095-4dannjjm 4870 18 of of IN cord-023095-4dannjjm 4870 19 5.5 5.5 CD cord-023095-4dannjjm 4870 20 months month NNS cord-023095-4dannjjm 4870 21 ( ( -LRB- cord-023095-4dannjjm 4870 22 range range VBP cord-023095-4dannjjm 4870 23 0.25 0.25 CD cord-023095-4dannjjm 4870 24 - - SYM cord-023095-4dannjjm 4870 25 9 9 CD cord-023095-4dannjjm 4870 26 ) ) -RRB- cord-023095-4dannjjm 4870 27 . . . cord-023095-4dannjjm 4871 1 Three three CD cord-023095-4dannjjm 4871 2 of of IN cord-023095-4dannjjm 4871 3 the the DT cord-023095-4dannjjm 4871 4 9 9 CD cord-023095-4dannjjm 4871 5 dogs dog NNS cord-023095-4dannjjm 4871 6 ( ( -LRB- cord-023095-4dannjjm 4871 7 33 33 CD cord-023095-4dannjjm 4871 8 % % NN cord-023095-4dannjjm 4871 9 ) ) -RRB- cord-023095-4dannjjm 4871 10 regained regain VBD cord-023095-4dannjjm 4871 11 normal normal JJ cord-023095-4dannjjm 4871 12 micturition micturition NN cord-023095-4dannjjm 4871 13 within within IN cord-023095-4dannjjm 4871 14 0.25 0.25 CD cord-023095-4dannjjm 4871 15 - - SYM cord-023095-4dannjjm 4871 16 1.5 1.5 CD cord-023095-4dannjjm 4871 17 months month NNS cord-023095-4dannjjm 4871 18 of of IN cord-023095-4dannjjm 4871 19 surgery surgery NN cord-023095-4dannjjm 4871 20 . . . cord-023095-4dannjjm 4872 1 Though though IN cord-023095-4dannjjm 4872 2 not not RB cord-023095-4dannjjm 4872 3 statistically statistically RB cord-023095-4dannjjm 4872 4 significant significant JJ cord-023095-4dannjjm 4872 5 , , , cord-023095-4dannjjm 4872 6 dogs dog NNS cord-023095-4dannjjm 4872 7 that that WDT cord-023095-4dannjjm 4872 8 regained regain VBD cord-023095-4dannjjm 4872 9 micturition micturition NN cord-023095-4dannjjm 4872 10 tended tend VBD cord-023095-4dannjjm 4872 11 to to TO cord-023095-4dannjjm 4872 12 have have VB cord-023095-4dannjjm 4872 13 a a DT cord-023095-4dannjjm 4872 14 shorter short JJR cord-023095-4dannjjm 4872 15 duration duration NN cord-023095-4dannjjm 4872 16 of of IN cord-023095-4dannjjm 4872 17 clinical clinical JJ cord-023095-4dannjjm 4872 18 signs sign NNS cord-023095-4dannjjm 4872 19 ( ( -LRB- cord-023095-4dannjjm 4872 20 median median NN cord-023095-4dannjjm 4872 21 0.25 0.25 CD cord-023095-4dannjjm 4872 22 months month NNS cord-023095-4dannjjm 4872 23 , , , cord-023095-4dannjjm 4872 24 range range VBP cord-023095-4dannjjm 4872 25 0.25 0.25 CD cord-023095-4dannjjm 4872 26 - - SYM cord-023095-4dannjjm 4872 27 2 2 CD cord-023095-4dannjjm 4872 28 ) ) -RRB- cord-023095-4dannjjm 4872 29 versus versus IN cord-023095-4dannjjm 4872 30 dogs dog NNS cord-023095-4dannjjm 4872 31 that that WDT cord-023095-4dannjjm 4872 32 remained remain VBD cord-023095-4dannjjm 4872 33 dysuric dysuric NNP cord-023095-4dannjjm 4872 34 ( ( -LRB- cord-023095-4dannjjm 4872 35 median median JJ cord-023095-4dannjjm 4872 36 5 5 CD cord-023095-4dannjjm 4872 37 months month NNS cord-023095-4dannjjm 4872 38 , , , cord-023095-4dannjjm 4872 39 range range VBP cord-023095-4dannjjm 4872 40 2 2 CD cord-023095-4dannjjm 4872 41 - - SYM cord-023095-4dannjjm 4872 42 12 12 CD cord-023095-4dannjjm 4872 43 ) ) -RRB- cord-023095-4dannjjm 4872 44 . . . cord-023095-4dannjjm 4873 1 Two two CD cord-023095-4dannjjm 4873 2 of of IN cord-023095-4dannjjm 4873 3 the the DT cord-023095-4dannjjm 4873 4 3 3 CD cord-023095-4dannjjm 4873 5 dogs dog NNS cord-023095-4dannjjm 4873 6 that that WDT cord-023095-4dannjjm 4873 7 regained regain VBD cord-023095-4dannjjm 4873 8 micturition micturition NN cord-023095-4dannjjm 4873 9 were be VBD cord-023095-4dannjjm 4873 10 neutered neuter VBN cord-023095-4dannjjm 4873 11 at at IN cord-023095-4dannjjm 4873 12 the the DT cord-023095-4dannjjm 4873 13 onset onset NN cord-023095-4dannjjm 4873 14 of of IN cord-023095-4dannjjm 4873 15 clinical clinical JJ cord-023095-4dannjjm 4873 16 signs sign NNS cord-023095-4dannjjm 4873 17 , , , cord-023095-4dannjjm 4873 18 but but CC cord-023095-4dannjjm 4873 19 only only RB cord-023095-4dannjjm 4873 20 1of 1of NN cord-023095-4dannjjm 4873 21 6 6 CD cord-023095-4dannjjm 4873 22 dogs dog NNS cord-023095-4dannjjm 4873 23 that that WDT cord-023095-4dannjjm 4873 24 remained remain VBD cord-023095-4dannjjm 4873 25 dysuric dysuric NNP cord-023095-4dannjjm 4873 26 was be VBD cord-023095-4dannjjm 4873 27 neutered neuter VBN cord-023095-4dannjjm 4873 28 . . . cord-023095-4dannjjm 4874 1 Signs sign NNS cord-023095-4dannjjm 4874 2 improved improve VBN cord-023095-4dannjjm 4874 3 in in IN cord-023095-4dannjjm 4874 4 all all DT cord-023095-4dannjjm 4874 5 dogs dog NNS cord-023095-4dannjjm 4874 6 with with IN cord-023095-4dannjjm 4874 7 postural postural JJ cord-023095-4dannjjm 4874 8 reaction reaction NN cord-023095-4dannjjm 4874 9 deficits deficit NNS cord-023095-4dannjjm 4874 10 and and CC cord-023095-4dannjjm 4874 11 decreased decrease VBD cord-023095-4dannjjm 4874 12 tail tail NN cord-023095-4dannjjm 4874 13 tone tone NN cord-023095-4dannjjm 4874 14 . . . cord-023095-4dannjjm 4875 1 Hyperesthesia Hyperesthesia NNP cord-023095-4dannjjm 4875 2 resolved resolve VBD cord-023095-4dannjjm 4875 3 in in IN cord-023095-4dannjjm 4875 4 5 5 CD cord-023095-4dannjjm 4875 5 of of IN cord-023095-4dannjjm 4875 6 6 6 CD cord-023095-4dannjjm 4875 7 dogs dog NNS cord-023095-4dannjjm 4875 8 ( ( -LRB- cord-023095-4dannjjm 4875 9 83 83 CD cord-023095-4dannjjm 4875 10 % % NN cord-023095-4dannjjm 4875 11 ) ) -RRB- cord-023095-4dannjjm 4875 12 and and CC cord-023095-4dannjjm 4875 13 fecal fecal JJ cord-023095-4dannjjm 4875 14 continence continence NN cord-023095-4dannjjm 4875 15 returned return VBD cord-023095-4dannjjm 4875 16 in in IN cord-023095-4dannjjm 4875 17 2 2 CD cord-023095-4dannjjm 4875 18 of of IN cord-023095-4dannjjm 4875 19 4 4 CD cord-023095-4dannjjm 4875 20 dogs dog NNS cord-023095-4dannjjm 4875 21 ( ( -LRB- cord-023095-4dannjjm 4875 22 50 50 CD cord-023095-4dannjjm 4875 23 % % NN cord-023095-4dannjjm 4875 24 ) ) -RRB- cord-023095-4dannjjm 4875 25 . . . cord-023095-4dannjjm 4876 1 These these DT cord-023095-4dannjjm 4876 2 findings finding NNS cord-023095-4dannjjm 4876 3 suggest suggest VBP cord-023095-4dannjjm 4876 4 that that IN cord-023095-4dannjjm 4876 5 following follow VBG cord-023095-4dannjjm 4876 6 prompt prompt JJ cord-023095-4dannjjm 4876 7 diagnosis diagnosis NN cord-023095-4dannjjm 4876 8 and and CC cord-023095-4dannjjm 4876 9 surgical surgical JJ cord-023095-4dannjjm 4876 10 decompression decompression NN cord-023095-4dannjjm 4876 11 , , , cord-023095-4dannjjm 4876 12 normal normal JJ cord-023095-4dannjjm 4876 13 micturition micturition NN cord-023095-4dannjjm 4876 14 could could MD cord-023095-4dannjjm 4876 15 be be VB cord-023095-4dannjjm 4876 16 regained regain VBN cord-023095-4dannjjm 4876 17 in in IN cord-023095-4dannjjm 4876 18 DLSS DLSS NNP cord-023095-4dannjjm 4876 19 affected affect VBD cord-023095-4dannjjm 4876 20 dogs dog NNS cord-023095-4dannjjm 4876 21 presenting present VBG cord-023095-4dannjjm 4876 22 with with IN cord-023095-4dannjjm 4876 23 signs sign NNS cord-023095-4dannjjm 4876 24 of of IN cord-023095-4dannjjm 4876 25 dysuria dysuria NNS cord-023095-4dannjjm 4876 26 . . . cord-023095-4dannjjm 4877 1 Glycogen glycogen NN cord-023095-4dannjjm 4877 2 storage storage NN cord-023095-4dannjjm 4877 3 disease disease NN cord-023095-4dannjjm 4877 4 type type NN cord-023095-4dannjjm 4878 1 Ia Ia NNP cord-023095-4dannjjm 4878 2 ( ( -LRB- cord-023095-4dannjjm 4878 3 GSDIa GSDIa NNS cord-023095-4dannjjm 4878 4 ; ; : cord-023095-4dannjjm 4878 5 von von NNP cord-023095-4dannjjm 4878 6 Gierke Gierke NNP cord-023095-4dannjjm 4878 7 disease disease NN cord-023095-4dannjjm 4878 8 ) ) -RRB- cord-023095-4dannjjm 4878 9 is be VBZ cord-023095-4dannjjm 4878 10 an an DT cord-023095-4dannjjm 4878 11 inherited inherit VBN cord-023095-4dannjjm 4878 12 metabolic metabolic JJ cord-023095-4dannjjm 4878 13 disorder disorder NN cord-023095-4dannjjm 4878 14 resulting result VBG cord-023095-4dannjjm 4878 15 from from IN cord-023095-4dannjjm 4878 16 a a DT cord-023095-4dannjjm 4878 17 deficiency deficiency NN cord-023095-4dannjjm 4878 18 of of IN cord-023095-4dannjjm 4878 19 glucose glucose NN cord-023095-4dannjjm 4878 20 6-phosphatase 6-phosphatase CD cord-023095-4dannjjm 4878 21 - - HYPH cord-023095-4dannjjm 4878 22 a a NN cord-023095-4dannjjm 4878 23 ( ( -LRB- cord-023095-4dannjjm 4878 24 G6Pase G6Pase NNP cord-023095-4dannjjm 4878 25 ) ) -RRB- cord-023095-4dannjjm 4878 26 . . . cord-023095-4dannjjm 4879 1 Previous previous JJ cord-023095-4dannjjm 4879 2 reports report NNS cord-023095-4dannjjm 4879 3 indicate indicate VBP cord-023095-4dannjjm 4879 4 that that IN cord-023095-4dannjjm 4879 5 clinical clinical JJ cord-023095-4dannjjm 4879 6 manifestations manifestation NNS cord-023095-4dannjjm 4879 7 of of IN cord-023095-4dannjjm 4879 8 GSDIa GSDIa NNS cord-023095-4dannjjm 4879 9 occur occur VBP cord-023095-4dannjjm 4879 10 only only RB cord-023095-4dannjjm 4879 11 in in IN cord-023095-4dannjjm 4879 12 individuals individual NNS cord-023095-4dannjjm 4879 13 with with IN cord-023095-4dannjjm 4879 14 homozygous homozygous JJ cord-023095-4dannjjm 4879 15 expression expression NN cord-023095-4dannjjm 4879 16 of of IN cord-023095-4dannjjm 4879 17 a a DT cord-023095-4dannjjm 4879 18 p. p. NN cord-023095-4dannjjm 4880 1 I121L I121L NNP cord-023095-4dannjjm 4880 2 mutation mutation NN cord-023095-4dannjjm 4880 3 . . . cord-023095-4dannjjm 4881 1 Heterozygote Heterozygote NNP cord-023095-4dannjjm 4881 2 dogs dog NNS cord-023095-4dannjjm 4881 3 ( ( -LRB- cord-023095-4dannjjm 4881 4 Het Het NNP cord-023095-4dannjjm 4881 5 ) ) -RRB- cord-023095-4dannjjm 4881 6 have have VBP cord-023095-4dannjjm 4881 7 been be VBN cord-023095-4dannjjm 4881 8 previously previously RB cord-023095-4dannjjm 4881 9 reported report VBN cord-023095-4dannjjm 4881 10 to to TO cord-023095-4dannjjm 4881 11 exhibit exhibit VB cord-023095-4dannjjm 4881 12 an an DT cord-023095-4dannjjm 4881 13 overall overall JJ cord-023095-4dannjjm 4881 14 normal normal JJ cord-023095-4dannjjm 4881 15 outward outward JJ cord-023095-4dannjjm 4881 16 phenotype phenotype NN cord-023095-4dannjjm 4881 17 . . . cord-023095-4dannjjm 4882 1 The the DT cord-023095-4dannjjm 4882 2 purpose purpose NN cord-023095-4dannjjm 4882 3 of of IN cord-023095-4dannjjm 4882 4 this this DT cord-023095-4dannjjm 4882 5 report report NN cord-023095-4dannjjm 4882 6 is be VBZ cord-023095-4dannjjm 4882 7 to to TO cord-023095-4dannjjm 4882 8 briefly briefly RB cord-023095-4dannjjm 4882 9 describe describe VB cord-023095-4dannjjm 4882 10 some some DT cord-023095-4dannjjm 4882 11 differences difference NNS cord-023095-4dannjjm 4882 12 that that WDT cord-023095-4dannjjm 4882 13 have have VBP cord-023095-4dannjjm 4882 14 been be VBN cord-023095-4dannjjm 4882 15 observed observe VBN cord-023095-4dannjjm 4882 16 between between IN cord-023095-4dannjjm 4882 17 Het Het NNP cord-023095-4dannjjm 4882 18 and and CC cord-023095-4dannjjm 4882 19 homozygous homozygous JJ cord-023095-4dannjjm 4882 20 wild wild JJ cord-023095-4dannjjm 4882 21 type type NN cord-023095-4dannjjm 4882 22 ( ( -LRB- cord-023095-4dannjjm 4882 23 WT WT NNP cord-023095-4dannjjm 4882 24 ) ) -RRB- cord-023095-4dannjjm 4882 25 dogs dog NNS cord-023095-4dannjjm 4882 26 . . . cord-023095-4dannjjm 4883 1 A a DT cord-023095-4dannjjm 4883 2 colony colony NN cord-023095-4dannjjm 4883 3 of of IN cord-023095-4dannjjm 4883 4 dogs dog NNS cord-023095-4dannjjm 4883 5 at at IN cord-023095-4dannjjm 4883 6 the the DT cord-023095-4dannjjm 4883 7 University University NNP cord-023095-4dannjjm 4883 8 of of IN cord-023095-4dannjjm 4883 9 Florida Florida NNP cord-023095-4dannjjm 4883 10 contains contain VBZ cord-023095-4dannjjm 4883 11 a a DT cord-023095-4dannjjm 4883 12 mix mix NN cord-023095-4dannjjm 4883 13 of of IN cord-023095-4dannjjm 4883 14 affected affect VBN cord-023095-4dannjjm 4883 15 , , , cord-023095-4dannjjm 4883 16 WT WT NNP cord-023095-4dannjjm 4883 17 , , , cord-023095-4dannjjm 4883 18 and and CC cord-023095-4dannjjm 4883 19 Het Het NNP cord-023095-4dannjjm 4883 20 individuals individual NNS cord-023095-4dannjjm 4883 21 . . . cord-023095-4dannjjm 4884 1 In in IN cord-023095-4dannjjm 4884 2 the the DT cord-023095-4dannjjm 4884 3 course course NN cord-023095-4dannjjm 4884 4 of of IN cord-023095-4dannjjm 4884 5 studies study NNS cord-023095-4dannjjm 4884 6 designed design VBN cord-023095-4dannjjm 4884 7 to to TO cord-023095-4dannjjm 4884 8 determine determine VB cord-023095-4dannjjm 4884 9 the the DT cord-023095-4dannjjm 4884 10 effectiveness effectiveness NN cord-023095-4dannjjm 4884 11 of of IN cord-023095-4dannjjm 4884 12 gene gene NN cord-023095-4dannjjm 4884 13 therapy therapy NN cord-023095-4dannjjm 4884 14 for for IN cord-023095-4dannjjm 4884 15 correction correction NN cord-023095-4dannjjm 4884 16 of of IN cord-023095-4dannjjm 4884 17 GSDIa GSDIa NNS cord-023095-4dannjjm 4884 18 in in IN cord-023095-4dannjjm 4884 19 dogs dog NNS cord-023095-4dannjjm 4884 20 , , , cord-023095-4dannjjm 4884 21 both both CC cord-023095-4dannjjm 4884 22 WT WT NNP cord-023095-4dannjjm 4884 23 and and CC cord-023095-4dannjjm 4884 24 Het Het NNP cord-023095-4dannjjm 4884 25 dogs dog NNS cord-023095-4dannjjm 4884 26 have have VBP cord-023095-4dannjjm 4884 27 been be VBN cord-023095-4dannjjm 4884 28 utilized utilize VBN cord-023095-4dannjjm 4884 29 as as IN cord-023095-4dannjjm 4884 30 controls control NNS cord-023095-4dannjjm 4884 31 . . . cord-023095-4dannjjm 4885 1 Available available JJ cord-023095-4dannjjm 4885 2 information information NN cord-023095-4dannjjm 4885 3 about about IN cord-023095-4dannjjm 4885 4 body body NN cord-023095-4dannjjm 4885 5 weights weight NNS cord-023095-4dannjjm 4885 6 , , , cord-023095-4dannjjm 4885 7 clinical clinical JJ cord-023095-4dannjjm 4885 8 pathology pathology NN cord-023095-4dannjjm 4885 9 tests test NNS cord-023095-4dannjjm 4885 10 , , , cord-023095-4dannjjm 4885 11 fasting fast VBG cord-023095-4dannjjm 4885 12 studies study NNS cord-023095-4dannjjm 4885 13 , , , cord-023095-4dannjjm 4885 14 and and CC cord-023095-4dannjjm 4885 15 liver liver NN cord-023095-4dannjjm 4885 16 biopsies biopsy NNS cord-023095-4dannjjm 4885 17 was be VBD cord-023095-4dannjjm 4885 18 retrieved retrieve VBN cord-023095-4dannjjm 4885 19 from from IN cord-023095-4dannjjm 4885 20 records record NNS cord-023095-4dannjjm 4885 21 for for IN cord-023095-4dannjjm 4885 22 both both DT cord-023095-4dannjjm 4885 23 WT WT NNP cord-023095-4dannjjm 4885 24 and and CC cord-023095-4dannjjm 4885 25 Het Het NNP cord-023095-4dannjjm 4885 26 dogs dog NNS cord-023095-4dannjjm 4885 27 and and CC cord-023095-4dannjjm 4885 28 compared compare VBN cord-023095-4dannjjm 4885 29 . . . cord-023095-4dannjjm 4886 1 Although although IN cord-023095-4dannjjm 4886 2 birth birth NN cord-023095-4dannjjm 4886 3 weights weight NNS cord-023095-4dannjjm 4886 4 are be VBP cord-023095-4dannjjm 4886 5 similar similar JJ cord-023095-4dannjjm 4886 6 , , , cord-023095-4dannjjm 4886 7 Het Het NNP cord-023095-4dannjjm 4886 8 dogs dog NNS cord-023095-4dannjjm 4886 9 have have VBP cord-023095-4dannjjm 4886 10 a a DT cord-023095-4dannjjm 4886 11 slower slow JJR cord-023095-4dannjjm 4886 12 average average JJ cord-023095-4dannjjm 4886 13 rate rate NN cord-023095-4dannjjm 4886 14 of of IN cord-023095-4dannjjm 4886 15 weight weight NN cord-023095-4dannjjm 4886 16 gain gain NN cord-023095-4dannjjm 4886 17 than than IN cord-023095-4dannjjm 4886 18 WT WT NNP cord-023095-4dannjjm 4886 19 dogs dog NNS cord-023095-4dannjjm 4886 20 and and CC cord-023095-4dannjjm 4886 21 this this DT cord-023095-4dannjjm 4886 22 difference difference NN cord-023095-4dannjjm 4886 23 is be VBZ cord-023095-4dannjjm 4886 24 especially especially RB cord-023095-4dannjjm 4886 25 prominent prominent JJ cord-023095-4dannjjm 4886 26 during during IN cord-023095-4dannjjm 4886 27 the the DT cord-023095-4dannjjm 4886 28 first first JJ cord-023095-4dannjjm 4886 29 few few JJ cord-023095-4dannjjm 4886 30 months month NNS cord-023095-4dannjjm 4886 31 of of IN cord-023095-4dannjjm 4886 32 life life NN cord-023095-4dannjjm 4886 33 ( ( -LRB- cord-023095-4dannjjm 4886 34 Figure figure NN cord-023095-4dannjjm 4886 35 1 1 CD cord-023095-4dannjjm 4886 36 ) ) -RRB- cord-023095-4dannjjm 4886 37 . . . cord-023095-4dannjjm 4887 1 In in IN cord-023095-4dannjjm 4887 2 contrast contrast NN cord-023095-4dannjjm 4887 3 to to IN cord-023095-4dannjjm 4887 4 affected affect VBN cord-023095-4dannjjm 4887 5 dogs dog NNS cord-023095-4dannjjm 4887 6 , , , cord-023095-4dannjjm 4887 7 both both CC cord-023095-4dannjjm 4887 8 WT WT NNP cord-023095-4dannjjm 4887 9 and and CC cord-023095-4dannjjm 4887 10 Het Het NNP cord-023095-4dannjjm 4887 11 dogs dog NNS cord-023095-4dannjjm 4887 12 are be VBP cord-023095-4dannjjm 4887 13 able able JJ cord-023095-4dannjjm 4887 14 to to TO cord-023095-4dannjjm 4887 15 maintain maintain VB cord-023095-4dannjjm 4887 16 normal normal JJ cord-023095-4dannjjm 4887 17 blood blood NN cord-023095-4dannjjm 4887 18 glucose glucose NN cord-023095-4dannjjm 4887 19 concentrations concentration NNS cord-023095-4dannjjm 4887 20 for for IN cord-023095-4dannjjm 4887 21 up up IN cord-023095-4dannjjm 4887 22 to to TO cord-023095-4dannjjm 4887 23 10 10 CD cord-023095-4dannjjm 4887 24 - - SYM cord-023095-4dannjjm 4887 25 12 12 CD cord-023095-4dannjjm 4887 26 hours hour NNS cord-023095-4dannjjm 4887 27 of of IN cord-023095-4dannjjm 4887 28 fasting fasting NN cord-023095-4dannjjm 4887 29 , , , cord-023095-4dannjjm 4887 30 however however RB cord-023095-4dannjjm 4887 31 , , , cord-023095-4dannjjm 4887 32 after after IN cord-023095-4dannjjm 4887 33 longer long JJR cord-023095-4dannjjm 4887 34 fasts fast NNS cord-023095-4dannjjm 4887 35 of of IN cord-023095-4dannjjm 4887 36 12 12 CD cord-023095-4dannjjm 4887 37 - - SYM cord-023095-4dannjjm 4887 38 17 17 CD cord-023095-4dannjjm 4887 39 hours hour NNS cord-023095-4dannjjm 4887 40 , , , cord-023095-4dannjjm 4887 41 Het Het NNP cord-023095-4dannjjm 4887 42 dogs dog NNS cord-023095-4dannjjm 4887 43 have have VBP cord-023095-4dannjjm 4887 44 lower low JJR cord-023095-4dannjjm 4887 45 glucose glucose NN cord-023095-4dannjjm 4887 46 and and CC cord-023095-4dannjjm 4887 47 higher high JJR cord-023095-4dannjjm 4887 48 lactate lactate NN cord-023095-4dannjjm 4887 49 concentrations concentration NNS cord-023095-4dannjjm 4887 50 ( ( -LRB- cord-023095-4dannjjm 4887 51 Table Table NNP cord-023095-4dannjjm 4887 52 2 2 CD cord-023095-4dannjjm 4887 53 ) ) -RRB- cord-023095-4dannjjm 4887 54 . . . cord-023095-4dannjjm 4888 1 In in IN cord-023095-4dannjjm 4888 2 addition addition NN cord-023095-4dannjjm 4888 3 , , , cord-023095-4dannjjm 4888 4 liver liver NN cord-023095-4dannjjm 4888 5 biopsy biopsy NN cord-023095-4dannjjm 4888 6 samples sample NNS cord-023095-4dannjjm 4888 7 from from IN cord-023095-4dannjjm 4888 8 Het Het NNP cord-023095-4dannjjm 4888 9 dogs dog NNS cord-023095-4dannjjm 4888 10 had have VBD cord-023095-4dannjjm 4888 11 greater great JJR cord-023095-4dannjjm 4888 12 apparent apparent JJ cord-023095-4dannjjm 4888 13 levels level NNS cord-023095-4dannjjm 4888 14 of of IN cord-023095-4dannjjm 4888 15 glycogen glycogen NN cord-023095-4dannjjm 4888 16 suggested suggest VBN cord-023095-4dannjjm 4888 17 by by IN cord-023095-4dannjjm 4888 18 PAS pas NN cord-023095-4dannjjm 4888 19 staining staining NN cord-023095-4dannjjm 4888 20 than than IN cord-023095-4dannjjm 4888 21 did do VBD cord-023095-4dannjjm 4888 22 samples sample NNS cord-023095-4dannjjm 4888 23 from from IN cord-023095-4dannjjm 4888 24 WT wt NN cord-023095-4dannjjm 4888 25 dogs dog NNS cord-023095-4dannjjm 4888 26 , , , cord-023095-4dannjjm 4888 27 and and CC cord-023095-4dannjjm 4888 28 this this DT cord-023095-4dannjjm 4888 29 correlated correlate VBD cord-023095-4dannjjm 4888 30 with with IN cord-023095-4dannjjm 4888 31 the the DT cord-023095-4dannjjm 4888 32 results result NNS cord-023095-4dannjjm 4888 33 of of IN cord-023095-4dannjjm 4888 34 proton proton NN cord-023095-4dannjjm 4888 35 magnetic magnetic JJ cord-023095-4dannjjm 4888 36 resonance resonance NN cord-023095-4dannjjm 4888 37 spectroscopy spectroscopy NN cord-023095-4dannjjm 4888 38 which which WDT cord-023095-4dannjjm 4888 39 demonstrated demonstrate VBD cord-023095-4dannjjm 4888 40 2.9 2.9 CD cord-023095-4dannjjm 4888 41 times time NNS cord-023095-4dannjjm 4888 42 greater great JJR cord-023095-4dannjjm 4888 43 glycogen glycogen NN cord-023095-4dannjjm 4888 44 content content NN cord-023095-4dannjjm 4888 45 in in IN cord-023095-4dannjjm 4888 46 a a DT cord-023095-4dannjjm 4888 47 liver liver NN cord-023095-4dannjjm 4888 48 biopsy biopsy NN cord-023095-4dannjjm 4888 49 sample sample NN cord-023095-4dannjjm 4888 50 from from IN cord-023095-4dannjjm 4888 51 a a DT cord-023095-4dannjjm 4888 52 Het Het NNP cord-023095-4dannjjm 4888 53 dog dog NN cord-023095-4dannjjm 4888 54 compared compare VBN cord-023095-4dannjjm 4888 55 to to IN cord-023095-4dannjjm 4888 56 a a DT cord-023095-4dannjjm 4888 57 sample sample NN cord-023095-4dannjjm 4888 58 from from IN cord-023095-4dannjjm 4888 59 a a DT cord-023095-4dannjjm 4888 60 WT WT NNP cord-023095-4dannjjm 4888 61 dog dog NN cord-023095-4dannjjm 4888 62 . . . cord-023095-4dannjjm 4889 1 Together together RB cord-023095-4dannjjm 4889 2 , , , cord-023095-4dannjjm 4889 3 these these DT cord-023095-4dannjjm 4889 4 findings finding NNS cord-023095-4dannjjm 4889 5 suggest suggest VBP cord-023095-4dannjjm 4889 6 that that IN cord-023095-4dannjjm 4889 7 the the DT cord-023095-4dannjjm 4889 8 level level NN cord-023095-4dannjjm 4889 9 of of IN cord-023095-4dannjjm 4889 10 G6Pase G6Pase NNP cord-023095-4dannjjm 4889 11 activity activity NN cord-023095-4dannjjm 4889 12 in in IN cord-023095-4dannjjm 4889 13 heterozygote heterozygote NN cord-023095-4dannjjm 4889 14 dogs dog NNS cord-023095-4dannjjm 4889 15 does do VBZ cord-023095-4dannjjm 4889 16 not not RB cord-023095-4dannjjm 4889 17 provide provide VB cord-023095-4dannjjm 4889 18 a a DT cord-023095-4dannjjm 4889 19 completely completely RB cord-023095-4dannjjm 4889 20 normal normal JJ cord-023095-4dannjjm 4889 21 physiological physiological JJ cord-023095-4dannjjm 4889 22 , , , cord-023095-4dannjjm 4889 23 biochemical biochemical JJ cord-023095-4dannjjm 4889 24 , , , cord-023095-4dannjjm 4889 25 or or CC cord-023095-4dannjjm 4889 26 histological histological JJ cord-023095-4dannjjm 4889 27 phenotype phenotype NN cord-023095-4dannjjm 4889 28 as as IN cord-023095-4dannjjm 4889 29 previously previously RB cord-023095-4dannjjm 4889 30 reported report VBN cord-023095-4dannjjm 4889 31 . . . cord-023095-4dannjjm 4890 1 The the DT cord-023095-4dannjjm 4890 2 glucokinase glucokinase NN cord-023095-4dannjjm 4890 3 gene gene NN cord-023095-4dannjjm 4890 4 ( ( -LRB- cord-023095-4dannjjm 4890 5 GCK GCK NNP cord-023095-4dannjjm 4890 6 ) ) -RRB- cord-023095-4dannjjm 4890 7 encodes encode VBZ cord-023095-4dannjjm 4890 8 an an DT cord-023095-4dannjjm 4890 9 enzyme enzyme NN cord-023095-4dannjjm 4890 10 involved involve VBN cord-023095-4dannjjm 4890 11 in in IN cord-023095-4dannjjm 4890 12 cellular cellular JJ cord-023095-4dannjjm 4890 13 glucose glucose NN cord-023095-4dannjjm 4890 14 - - HYPH cord-023095-4dannjjm 4890 15 sensing sense VBG cord-023095-4dannjjm 4890 16 mechanisms mechanism NNS cord-023095-4dannjjm 4890 17 in in IN cord-023095-4dannjjm 4890 18 pancreatic pancreatic JJ cord-023095-4dannjjm 4890 19 beta beta NN cord-023095-4dannjjm 4890 20 cells cell NNS cord-023095-4dannjjm 4890 21 and and CC cord-023095-4dannjjm 4890 22 hepatocytes hepatocyte NNS cord-023095-4dannjjm 4890 23 . . . cord-023095-4dannjjm 4891 1 GCK GCK NNP cord-023095-4dannjjm 4891 2 mRNA mRNA NNP cord-023095-4dannjjm 4891 3 is be VBZ cord-023095-4dannjjm 4891 4 present present JJ cord-023095-4dannjjm 4891 5 in in IN cord-023095-4dannjjm 4891 6 feline feline JJ cord-023095-4dannjjm 4891 7 pancreas pancrea NNS cord-023095-4dannjjm 4891 8 but but CC cord-023095-4dannjjm 4891 9 the the DT cord-023095-4dannjjm 4891 10 gene gene NN cord-023095-4dannjjm 4891 11 is be VBZ cord-023095-4dannjjm 4891 12 not not RB cord-023095-4dannjjm 4891 13 expressed express VBN cord-023095-4dannjjm 4891 14 in in IN cord-023095-4dannjjm 4891 15 feline feline JJ cord-023095-4dannjjm 4891 16 liver liver NN cord-023095-4dannjjm 4891 17 . . . cord-023095-4dannjjm 4892 1 Hepatic hepatic JJ cord-023095-4dannjjm 4892 2 GCK GCK NNP cord-023095-4dannjjm 4892 3 expression expression NN cord-023095-4dannjjm 4892 4 is be VBZ cord-023095-4dannjjm 4892 5 abundant abundant JJ cord-023095-4dannjjm 4892 6 in in IN cord-023095-4dannjjm 4892 7 omnivores omnivore NNS cord-023095-4dannjjm 4892 8 so so IN cord-023095-4dannjjm 4892 9 its -PRON- PRP$ cord-023095-4dannjjm 4892 10 absence absence NN cord-023095-4dannjjm 4892 11 may may MD cord-023095-4dannjjm 4892 12 reflect reflect VB cord-023095-4dannjjm 4892 13 an an DT cord-023095-4dannjjm 4892 14 evolutionary evolutionary JJ cord-023095-4dannjjm 4892 15 adaptation adaptation NN cord-023095-4dannjjm 4892 16 of of IN cord-023095-4dannjjm 4892 17 strict strict JJ cord-023095-4dannjjm 4892 18 carnivores carnivore NNS cord-023095-4dannjjm 4892 19 , , , cord-023095-4dannjjm 4892 20 like like IN cord-023095-4dannjjm 4892 21 feline feline JJ cord-023095-4dannjjm 4892 22 species specie NNS cord-023095-4dannjjm 4892 23 . . . cord-023095-4dannjjm 4893 1 We -PRON- PRP cord-023095-4dannjjm 4893 2 hypothesized hypothesize VBD cord-023095-4dannjjm 4893 3 speciesspecific speciesspecific NN cord-023095-4dannjjm 4893 4 features feature NNS cord-023095-4dannjjm 4893 5 in in IN cord-023095-4dannjjm 4893 6 the the DT cord-023095-4dannjjm 4893 7 GCK GCK NNP cord-023095-4dannjjm 4893 8 hepatic hepatic JJ cord-023095-4dannjjm 4893 9 promoter promoter NN cord-023095-4dannjjm 4893 10 may may MD cord-023095-4dannjjm 4893 11 underlie underlie VB cord-023095-4dannjjm 4893 12 the the DT cord-023095-4dannjjm 4893 13 gene gene NN cord-023095-4dannjjm 4893 14 expression expression NN cord-023095-4dannjjm 4893 15 pattern pattern NN cord-023095-4dannjjm 4893 16 observed observe VBN cord-023095-4dannjjm 4893 17 in in IN cord-023095-4dannjjm 4893 18 cats cat NNS cord-023095-4dannjjm 4893 19 . . . cord-023095-4dannjjm 4894 1 The the DT cord-023095-4dannjjm 4894 2 putative putative JJ cord-023095-4dannjjm 4894 3 feline feline JJ cord-023095-4dannjjm 4894 4 GCK GCK NNP cord-023095-4dannjjm 4894 5 ( ( -LRB- cord-023095-4dannjjm 4894 6 fGCK fgck NN cord-023095-4dannjjm 4894 7 ) ) -RRB- cord-023095-4dannjjm 4894 8 promoter promoter NN cord-023095-4dannjjm 4894 9 region region NN cord-023095-4dannjjm 4894 10 was be VBD cord-023095-4dannjjm 4894 11 located locate VBN cord-023095-4dannjjm 4894 12 using use VBG cord-023095-4dannjjm 4894 13 bioinformatic bioinformatic JJ cord-023095-4dannjjm 4894 14 software software NN cord-023095-4dannjjm 4894 15 to to TO cord-023095-4dannjjm 4894 16 identify identify VB cord-023095-4dannjjm 4894 17 homology homology NN cord-023095-4dannjjm 4894 18 with with IN cord-023095-4dannjjm 4894 19 human human JJ cord-023095-4dannjjm 4894 20 GCK GCK NNP cord-023095-4dannjjm 4894 21 ( ( -LRB- cord-023095-4dannjjm 4894 22 hGCK hgck NN cord-023095-4dannjjm 4894 23 ) ) -RRB- cord-023095-4dannjjm 4894 24 . . . cord-023095-4dannjjm 4895 1 Genomic genomic JJ cord-023095-4dannjjm 4895 2 DNA dna NN cord-023095-4dannjjm 4895 3 from from IN cord-023095-4dannjjm 4895 4 a a DT cord-023095-4dannjjm 4895 5 DSH DSH NNP cord-023095-4dannjjm 4895 6 cat cat NN cord-023095-4dannjjm 4895 7 was be VBD cord-023095-4dannjjm 4895 8 subjected subject VBN cord-023095-4dannjjm 4895 9 to to IN cord-023095-4dannjjm 4895 10 direct direct JJ cord-023095-4dannjjm 4895 11 sequencing sequencing NN cord-023095-4dannjjm 4895 12 using use VBG cord-023095-4dannjjm 4895 13 a a DT cord-023095-4dannjjm 4895 14 series series NN cord-023095-4dannjjm 4895 15 of of IN cord-023095-4dannjjm 4895 16 PCR PCR NNP cord-023095-4dannjjm 4895 17 reactions reaction NNS cord-023095-4dannjjm 4895 18 with with IN cord-023095-4dannjjm 4895 19 speciesspecific speciesspecific NN cord-023095-4dannjjm 4895 20 primers primer NNS cord-023095-4dannjjm 4895 21 . . . cord-023095-4dannjjm 4896 1 DNA DNA NNP cord-023095-4dannjjm 4896 2 clones clone NNS cord-023095-4dannjjm 4896 3 thus thus RB cord-023095-4dannjjm 4896 4 obtained obtain VBN cord-023095-4dannjjm 4896 5 were be VBD cord-023095-4dannjjm 4896 6 aligned align VBN cord-023095-4dannjjm 4896 7 to to TO cord-023095-4dannjjm 4896 8 generate generate VB cord-023095-4dannjjm 4896 9 the the DT cord-023095-4dannjjm 4896 10 feline feline JJ cord-023095-4dannjjm 4896 11 sequence sequence NN cord-023095-4dannjjm 4896 12 . . . cord-023095-4dannjjm 4897 1 Direct direct JJ cord-023095-4dannjjm 4897 2 sequencing sequencing NN cord-023095-4dannjjm 4897 3 yielded yield VBD cord-023095-4dannjjm 4897 4 8.9 8.9 CD cord-023095-4dannjjm 4897 5 kb kb CD cord-023095-4dannjjm 4897 6 of of IN cord-023095-4dannjjm 4897 7 genomic genomic JJ cord-023095-4dannjjm 4897 8 DNA dna NN cord-023095-4dannjjm 4897 9 sequence sequence NN cord-023095-4dannjjm 4897 10 with with IN cord-023095-4dannjjm 4897 11 high high JJ cord-023095-4dannjjm 4897 12 homology homology NN cord-023095-4dannjjm 4897 13 with with IN cord-023095-4dannjjm 4897 14 sequences sequence NNS cord-023095-4dannjjm 4897 15 ( ( -LRB- cord-023095-4dannjjm 4897 16 ACBE01359231 ACBE01359231 NNP cord-023095-4dannjjm 4897 17 , , , cord-023095-4dannjjm 4897 18 ACBE01359221 acbe01359221 ADD cord-023095-4dannjjm 4897 19 ) ) -RRB- cord-023095-4dannjjm 4897 20 archived archive VBN cord-023095-4dannjjm 4897 21 in in IN cord-023095-4dannjjm 4897 22 the the DT cord-023095-4dannjjm 4897 23 feline feline JJ cord-023095-4dannjjm 4897 24 genome genome NN cord-023095-4dannjjm 4897 25 project project NN cord-023095-4dannjjm 4897 26 . . . cord-023095-4dannjjm 4898 1 The the DT cord-023095-4dannjjm 4898 2 feline feline JJ cord-023095-4dannjjm 4898 3 sequence sequence NN cord-023095-4dannjjm 4898 4 had have VBD cord-023095-4dannjjm 4898 5 six six CD cord-023095-4dannjjm 4898 6 regions region NNS cord-023095-4dannjjm 4898 7 homologous homologous JJ cord-023095-4dannjjm 4898 8 with with IN cord-023095-4dannjjm 4898 9 non non JJ cord-023095-4dannjjm 4898 10 - - JJ cord-023095-4dannjjm 4898 11 coding coding JJ cord-023095-4dannjjm 4898 12 regions region NNS cord-023095-4dannjjm 4898 13 of of IN cord-023095-4dannjjm 4898 14 hGCK hgck NN cord-023095-4dannjjm 4898 15 ; ; : cord-023095-4dannjjm 4898 16 four four CD cord-023095-4dannjjm 4898 17 of of IN cord-023095-4dannjjm 4898 18 these these DT cord-023095-4dannjjm 4898 19 conserved conserve VBN cord-023095-4dannjjm 4898 20 regions region NNS cord-023095-4dannjjm 4898 21 are be VBP cord-023095-4dannjjm 4898 22 upstream upstream RB cord-023095-4dannjjm 4898 23 of of IN cord-023095-4dannjjm 4898 24 the the DT cord-023095-4dannjjm 4898 25 putative putative JJ cord-023095-4dannjjm 4898 26 fGCK fgck NN cord-023095-4dannjjm 4898 27 start start NN cord-023095-4dannjjm 4898 28 . . . cord-023095-4dannjjm 4899 1 A a DT cord-023095-4dannjjm 4899 2 0.8 0.8 CD cord-023095-4dannjjm 4899 3 kb kb NNP cord-023095-4dannjjm 4899 4 segment segment NN cord-023095-4dannjjm 4899 5 immediately immediately RB cord-023095-4dannjjm 4899 6 upstream upstream RB cord-023095-4dannjjm 4899 7 of of IN cord-023095-4dannjjm 4899 8 feline feline JJ cord-023095-4dannjjm 4899 9 hepatic hepatic JJ cord-023095-4dannjjm 4899 10 exon exon NN cord-023095-4dannjjm 4899 11 1 1 CD cord-023095-4dannjjm 4899 12 is be VBZ cord-023095-4dannjjm 4899 13 not not RB cord-023095-4dannjjm 4899 14 present present JJ cord-023095-4dannjjm 4899 15 in in IN cord-023095-4dannjjm 4899 16 hGCK hgck NN cord-023095-4dannjjm 4899 17 . . . cord-023095-4dannjjm 4900 1 The the DT cord-023095-4dannjjm 4900 2 0.8 0.8 CD cord-023095-4dannjjm 4900 3 kb kb NNP cord-023095-4dannjjm 4900 4 insert insert NN cord-023095-4dannjjm 4900 5 is be VBZ cord-023095-4dannjjm 4900 6 the the DT cord-023095-4dannjjm 4900 7 reverse reverse JJ cord-023095-4dannjjm 4900 8 complement complement NN cord-023095-4dannjjm 4900 9 of of IN cord-023095-4dannjjm 4900 10 a a DT cord-023095-4dannjjm 4900 11 conserved conserve VBN cord-023095-4dannjjm 4900 12 sequence sequence NN cord-023095-4dannjjm 4900 13 located locate VBN cord-023095-4dannjjm 4900 14 downstream downstream RB cord-023095-4dannjjm 4900 15 of of IN cord-023095-4dannjjm 4900 16 exon exon NN cord-023095-4dannjjm 4900 17 1 1 CD cord-023095-4dannjjm 4900 18 in in IN cord-023095-4dannjjm 4900 19 feline feline JJ cord-023095-4dannjjm 4900 20 and and CC cord-023095-4dannjjm 4900 21 human human JJ cord-023095-4dannjjm 4900 22 sequences sequence NNS cord-023095-4dannjjm 4900 23 . . . cord-023095-4dannjjm 4901 1 In in IN cord-023095-4dannjjm 4901 2 conclusion conclusion NN cord-023095-4dannjjm 4901 3 , , , cord-023095-4dannjjm 4901 4 the the DT cord-023095-4dannjjm 4901 5 putative putative JJ cord-023095-4dannjjm 4901 6 hepatic hepatic JJ cord-023095-4dannjjm 4901 7 promoter promoter NN cord-023095-4dannjjm 4901 8 of of IN cord-023095-4dannjjm 4901 9 fGCK fgck NN cord-023095-4dannjjm 4901 10 shares share NNS cord-023095-4dannjjm 4901 11 extensive extensive JJ cord-023095-4dannjjm 4901 12 homology homology NN cord-023095-4dannjjm 4901 13 with with IN cord-023095-4dannjjm 4901 14 the the DT cord-023095-4dannjjm 4901 15 hGCK hgck NN cord-023095-4dannjjm 4901 16 promoter promoter NN cord-023095-4dannjjm 4901 17 but but CC cord-023095-4dannjjm 4901 18 contains contain VBZ cord-023095-4dannjjm 4901 19 a a DT cord-023095-4dannjjm 4901 20 0.8 0.8 CD cord-023095-4dannjjm 4901 21 kb kb NNP cord-023095-4dannjjm 4901 22 insert insert NN cord-023095-4dannjjm 4901 23 not not RB cord-023095-4dannjjm 4901 24 found find VBN cord-023095-4dannjjm 4901 25 in in IN cord-023095-4dannjjm 4901 26 hGCK hgck NN cord-023095-4dannjjm 4901 27 . . . cord-023095-4dannjjm 4902 1 Functional functional JJ cord-023095-4dannjjm 4902 2 studies study NNS cord-023095-4dannjjm 4902 3 are be VBP cord-023095-4dannjjm 4902 4 needed need VBN cord-023095-4dannjjm 4902 5 to to TO cord-023095-4dannjjm 4902 6 confirm confirm VB cord-023095-4dannjjm 4902 7 the the DT cord-023095-4dannjjm 4902 8 role role NN cord-023095-4dannjjm 4902 9 of of IN cord-023095-4dannjjm 4902 10 the the DT cord-023095-4dannjjm 4902 11 unique unique JJ cord-023095-4dannjjm 4902 12 insert insert NN cord-023095-4dannjjm 4902 13 in in IN cord-023095-4dannjjm 4902 14 regulation regulation NN cord-023095-4dannjjm 4902 15 of of IN cord-023095-4dannjjm 4902 16 fGCK fgck NN cord-023095-4dannjjm 4902 17 gene gene NN cord-023095-4dannjjm 4902 18 expression expression NN cord-023095-4dannjjm 4902 19 . . . cord-023095-4dannjjm 4903 1 Deuterium deuterium NN cord-023095-4dannjjm 4903 2 oxide oxide NN cord-023095-4dannjjm 4903 3 ( ( -LRB- cord-023095-4dannjjm 4903 4 D d NN cord-023095-4dannjjm 4903 5 2 2 CD cord-023095-4dannjjm 4903 6 O o NN cord-023095-4dannjjm 4903 7 ) ) -RRB- cord-023095-4dannjjm 4903 8 dilution dilution NN cord-023095-4dannjjm 4903 9 has have VBZ cord-023095-4dannjjm 4903 10 been be VBN cord-023095-4dannjjm 4903 11 proposed propose VBN cord-023095-4dannjjm 4903 12 for for IN cord-023095-4dannjjm 4903 13 quantifying quantify VBG cord-023095-4dannjjm 4903 14 body body NN cord-023095-4dannjjm 4903 15 water water NN cord-023095-4dannjjm 4903 16 content content NN cord-023095-4dannjjm 4903 17 , , , cord-023095-4dannjjm 4903 18 but but CC cord-023095-4dannjjm 4903 19 remains remain VBZ cord-023095-4dannjjm 4903 20 difficult difficult JJ cord-023095-4dannjjm 4903 21 to to TO cord-023095-4dannjjm 4903 22 perform perform VB cord-023095-4dannjjm 4903 23 routinely routinely RB cord-023095-4dannjjm 4903 24 . . . cord-023095-4dannjjm 4904 1 The the DT cord-023095-4dannjjm 4904 2 objective objective NN cord-023095-4dannjjm 4904 3 of of IN cord-023095-4dannjjm 4904 4 this this DT cord-023095-4dannjjm 4904 5 study study NN cord-023095-4dannjjm 4904 6 was be VBD cord-023095-4dannjjm 4904 7 to to TO cord-023095-4dannjjm 4904 8 assess assess VB cord-023095-4dannjjm 4904 9 if if IN cord-023095-4dannjjm 4904 10 the the DT cord-023095-4dannjjm 4904 11 volume volume NN cord-023095-4dannjjm 4904 12 of of IN cord-023095-4dannjjm 4904 13 distribution distribution NN cord-023095-4dannjjm 4904 14 ( ( -LRB- cord-023095-4dannjjm 4904 15 Vd Vd NNP cord-023095-4dannjjm 4904 16 ) ) -RRB- cord-023095-4dannjjm 4904 17 of of IN cord-023095-4dannjjm 4904 18 creatinine creatinine NN cord-023095-4dannjjm 4904 19 could could MD cord-023095-4dannjjm 4904 20 be be VB cord-023095-4dannjjm 4904 21 proposed propose VBN cord-023095-4dannjjm 4904 22 as as IN cord-023095-4dannjjm 4904 23 an an DT cord-023095-4dannjjm 4904 24 alternative alternative NN cord-023095-4dannjjm 4904 25 in in IN cord-023095-4dannjjm 4904 26 dogs dog NNS cord-023095-4dannjjm 4904 27 for for IN cord-023095-4dannjjm 4904 28 such such PDT cord-023095-4dannjjm 4904 29 a a DT cord-023095-4dannjjm 4904 30 measurement measurement NN cord-023095-4dannjjm 4904 31 . . . cord-023095-4dannjjm 4905 1 Creatinine creatinine NN cord-023095-4dannjjm 4905 2 and and CC cord-023095-4dannjjm 4905 3 D d NN cord-023095-4dannjjm 4905 4 2 2 CD cord-023095-4dannjjm 4905 5 O o NN cord-023095-4dannjjm 4905 6 Vd vd NN cord-023095-4dannjjm 4905 7 were be VBD cord-023095-4dannjjm 4905 8 measured measure VBN cord-023095-4dannjjm 4905 9 before before RB cord-023095-4dannjjm 4905 10 ( ( -LRB- cord-023095-4dannjjm 4905 11 C C NNP cord-023095-4dannjjm 4905 12 ) ) -RRB- cord-023095-4dannjjm 4905 13 and and CC cord-023095-4dannjjm 4905 14 after after IN cord-023095-4dannjjm 4905 15 induction induction NN cord-023095-4dannjjm 4905 16 ( ( -LRB- cord-023095-4dannjjm 4905 17 O o UH cord-023095-4dannjjm 4905 18 ) ) -RRB- cord-023095-4dannjjm 4905 19 of of IN cord-023095-4dannjjm 4905 20 obesity obesity NN cord-023095-4dannjjm 4905 21 ( ( -LRB- cord-023095-4dannjjm 4905 22 by by IN cord-023095-4dannjjm 4905 23 giving give VBG cord-023095-4dannjjm 4905 24 an an DT cord-023095-4dannjjm 4905 25 hypercaloric hypercaloric NN cord-023095-4dannjjm 4905 26 diet diet NN cord-023095-4dannjjm 4905 27 ( ( -LRB- cord-023095-4dannjjm 4905 28 6100 6100 CD cord-023095-4dannjjm 4905 29 kcal/ kcal/ CD cord-023095-4dannjjm 4905 30 kg kg NNP cord-023095-4dannjjm 4905 31 ) ) -RRB- cord-023095-4dannjjm 4905 32 for for IN cord-023095-4dannjjm 4905 33 6 6 CD cord-023095-4dannjjm 4905 34 months month NNS cord-023095-4dannjjm 4905 35 ) ) -RRB- cord-023095-4dannjjm 4905 36 in in IN cord-023095-4dannjjm 4905 37 six six CD cord-023095-4dannjjm 4905 38 healthy healthy JJ cord-023095-4dannjjm 4905 39 adult adult NN cord-023095-4dannjjm 4905 40 Beagle Beagle NNP cord-023095-4dannjjm 4905 41 dogs dog NNS cord-023095-4dannjjm 4905 42 . . . cord-023095-4dannjjm 4906 1 Creatinine creatinine NN cord-023095-4dannjjm 4906 2 ( ( -LRB- cord-023095-4dannjjm 4906 3 40 40 CD cord-023095-4dannjjm 4906 4 mg mg NNP cord-023095-4dannjjm 4906 5 / / SYM cord-023095-4dannjjm 4906 6 kg kg NNP cord-023095-4dannjjm 4906 7 ) ) -RRB- cord-023095-4dannjjm 4906 8 and and CC cord-023095-4dannjjm 4906 9 D D NNP cord-023095-4dannjjm 4906 10 2 2 CD cord-023095-4dannjjm 4906 11 O o NN cord-023095-4dannjjm 4906 12 ( ( -LRB- cord-023095-4dannjjm 4906 13 200 200 CD cord-023095-4dannjjm 4906 14 mg mg NNP cord-023095-4dannjjm 4906 15 / / SYM cord-023095-4dannjjm 4906 16 kg kg NNP cord-023095-4dannjjm 4906 17 ) ) -RRB- cord-023095-4dannjjm 4906 18 were be VBD cord-023095-4dannjjm 4906 19 simultaneously simultaneously RB cord-023095-4dannjjm 4906 20 injected inject VBN cord-023095-4dannjjm 4906 21 by by IN cord-023095-4dannjjm 4906 22 bolus bolus NN cord-023095-4dannjjm 4906 23 iv iv NNP cord-023095-4dannjjm 4906 24 . . . cord-023095-4dannjjm 4907 1 Blood blood NN cord-023095-4dannjjm 4907 2 was be VBD cord-023095-4dannjjm 4907 3 collected collect VBN cord-023095-4dannjjm 4907 4 before before IN cord-023095-4dannjjm 4907 5 administration administration NN cord-023095-4dannjjm 4907 6 and and CC cord-023095-4dannjjm 4907 7 then then RB cord-023095-4dannjjm 4907 8 at at IN cord-023095-4dannjjm 4907 9 5 5 CD cord-023095-4dannjjm 4907 10 , , , cord-023095-4dannjjm 4907 11 10 10 CD cord-023095-4dannjjm 4907 12 , , , cord-023095-4dannjjm 4907 13 30 30 CD cord-023095-4dannjjm 4907 14 , , , cord-023095-4dannjjm 4907 15 60 60 CD cord-023095-4dannjjm 4907 16 , , , cord-023095-4dannjjm 4907 17 120 120 CD cord-023095-4dannjjm 4907 18 , , , cord-023095-4dannjjm 4907 19 180 180 CD cord-023095-4dannjjm 4907 20 , , , cord-023095-4dannjjm 4907 21 240 240 CD cord-023095-4dannjjm 4907 22 , , , cord-023095-4dannjjm 4907 23 360 360 CD cord-023095-4dannjjm 4907 24 , , , cord-023095-4dannjjm 4907 25 and and CC cord-023095-4dannjjm 4907 26 480 480 CD cord-023095-4dannjjm 4907 27 min min NN cord-023095-4dannjjm 4907 28 post post NN cord-023095-4dannjjm 4907 29 - - NN cord-023095-4dannjjm 4907 30 injection injection NN cord-023095-4dannjjm 4907 31 ( ( -LRB- cord-023095-4dannjjm 4907 32 creatinine creatinine NN cord-023095-4dannjjm 4907 33 ) ) -RRB- cord-023095-4dannjjm 4907 34 , , , cord-023095-4dannjjm 4907 35 and and CC cord-023095-4dannjjm 4907 36 10 10 CD cord-023095-4dannjjm 4907 37 , , , cord-023095-4dannjjm 4907 38 30 30 CD cord-023095-4dannjjm 4907 39 , , , cord-023095-4dannjjm 4907 40 60 60 CD cord-023095-4dannjjm 4907 41 , , , cord-023095-4dannjjm 4907 42 90 90 CD cord-023095-4dannjjm 4907 43 , , , cord-023095-4dannjjm 4907 44 120 120 CD cord-023095-4dannjjm 4907 45 , , , cord-023095-4dannjjm 4907 46 150 150 CD cord-023095-4dannjjm 4907 47 , , , cord-023095-4dannjjm 4907 48 180 180 CD cord-023095-4dannjjm 4907 49 and and CC cord-023095-4dannjjm 4907 50 240 240 CD cord-023095-4dannjjm 4907 51 min min NN cord-023095-4dannjjm 4907 52 ( ( -LRB- cord-023095-4dannjjm 4907 53 D d NN cord-023095-4dannjjm 4907 54 2 2 CD cord-023095-4dannjjm 4907 55 O o NN cord-023095-4dannjjm 4907 56 ) ) -RRB- cord-023095-4dannjjm 4907 57 . . . cord-023095-4dannjjm 4908 1 Plasma plasma NN cord-023095-4dannjjm 4908 2 concentrations concentration NNS cord-023095-4dannjjm 4908 3 of of IN cord-023095-4dannjjm 4908 4 both both DT cord-023095-4dannjjm 4908 5 markers marker NNS cord-023095-4dannjjm 4908 6 were be VBD cord-023095-4dannjjm 4908 7 determined determine VBN cord-023095-4dannjjm 4908 8 . . . cord-023095-4dannjjm 4909 1 Vd Vd NNP cord-023095-4dannjjm 4909 2 was be VBD cord-023095-4dannjjm 4909 3 calculated calculate VBN cord-023095-4dannjjm 4909 4 using use VBG cord-023095-4dannjjm 4909 5 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 4909 6 equations equation NNS cord-023095-4dannjjm 4909 7 . . . cord-023095-4dannjjm 4910 1 The the DT cord-023095-4dannjjm 4910 2 body body NN cord-023095-4dannjjm 4910 3 weight weight NN cord-023095-4dannjjm 4910 4 increased increase VBD cord-023095-4dannjjm 4910 5 from from IN cord-023095-4dannjjm 4910 6 10.7 10.7 CD cord-023095-4dannjjm 4910 7 AE AE NNP cord-023095-4dannjjm 4910 8 0.6 0.6 CD cord-023095-4dannjjm 4910 9 ( ( -LRB- cord-023095-4dannjjm 4910 10 C C NNP cord-023095-4dannjjm 4910 11 ) ) -RRB- cord-023095-4dannjjm 4910 12 ( ( -LRB- cord-023095-4dannjjm 4910 13 mean mean VB cord-023095-4dannjjm 4910 14 AE AE NNP cord-023095-4dannjjm 4910 15 SD SD NNP cord-023095-4dannjjm 4910 16 ) ) -RRB- cord-023095-4dannjjm 4910 17 to to IN cord-023095-4dannjjm 4910 18 15.8 15.8 CD cord-023095-4dannjjm 4910 19 AE AE NNP cord-023095-4dannjjm 4910 20 1.0 1.0 CD cord-023095-4dannjjm 4910 21 kg kg NNS cord-023095-4dannjjm 4910 22 ( ( -LRB- cord-023095-4dannjjm 4910 23 O o UH cord-023095-4dannjjm 4910 24 ) ) -RRB- cord-023095-4dannjjm 4910 25 . . . cord-023095-4dannjjm 4911 1 D d NN cord-023095-4dannjjm 4911 2 2 2 CD cord-023095-4dannjjm 4911 3 O o NN cord-023095-4dannjjm 4911 4 Vd vd NN cord-023095-4dannjjm 4911 5 decreased decrease VBD cord-023095-4dannjjm 4911 6 from from IN cord-023095-4dannjjm 4911 7 636 636 CD cord-023095-4dannjjm 4911 8 AE AE NNP cord-023095-4dannjjm 4911 9 18 18 CD cord-023095-4dannjjm 4911 10 ( ( -LRB- cord-023095-4dannjjm 4911 11 C C NNP cord-023095-4dannjjm 4911 12 ) ) -RRB- cord-023095-4dannjjm 4911 13 to to IN cord-023095-4dannjjm 4911 14 468 468 CD cord-023095-4dannjjm 4911 15 AE AE NNP cord-023095-4dannjjm 4911 16 19 19 CD cord-023095-4dannjjm 4912 1 ( ( -LRB- cord-023095-4dannjjm 4912 2 O o UH cord-023095-4dannjjm 4912 3 ) ) -RRB- cord-023095-4dannjjm 4912 4 mL ml NN cord-023095-4dannjjm 4912 5 / / SYM cord-023095-4dannjjm 4912 6 kg kg NN cord-023095-4dannjjm 4912 7 . . . cord-023095-4dannjjm 4913 1 Similarly similarly RB cord-023095-4dannjjm 4913 2 , , , cord-023095-4dannjjm 4913 3 creatinine creatinine NN cord-023095-4dannjjm 4913 4 Vd Vd NNP cord-023095-4dannjjm 4913 5 decreased decrease VBD cord-023095-4dannjjm 4913 6 from from IN cord-023095-4dannjjm 4913 7 624 624 CD cord-023095-4dannjjm 4913 8 AE AE NNP cord-023095-4dannjjm 4913 9 31 31 CD cord-023095-4dannjjm 4913 10 ( ( -LRB- cord-023095-4dannjjm 4913 11 C C NNP cord-023095-4dannjjm 4913 12 ) ) -RRB- cord-023095-4dannjjm 4913 13 to to IN cord-023095-4dannjjm 4913 14 420 420 CD cord-023095-4dannjjm 4913 15 AE AE NNP cord-023095-4dannjjm 4913 16 25 25 CD cord-023095-4dannjjm 4914 1 ( ( -LRB- cord-023095-4dannjjm 4914 2 O o UH cord-023095-4dannjjm 4914 3 ) ) -RRB- cord-023095-4dannjjm 4914 4 mL ml NN cord-023095-4dannjjm 4914 5 / / SYM cord-023095-4dannjjm 4914 6 kg kg NN cord-023095-4dannjjm 4914 7 . . . cord-023095-4dannjjm 4915 1 The the DT cord-023095-4dannjjm 4915 2 individual individual JJ cord-023095-4dannjjm 4915 3 difference difference NN cord-023095-4dannjjm 4915 4 between between IN cord-023095-4dannjjm 4915 5 creatinine creatinine NN cord-023095-4dannjjm 4915 6 and and CC cord-023095-4dannjjm 4915 7 D d NN cord-023095-4dannjjm 4915 8 2 2 CD cord-023095-4dannjjm 4915 9 O o NN cord-023095-4dannjjm 4915 10 Vd vd NN cord-023095-4dannjjm 4915 11 ( ( -LRB- cord-023095-4dannjjm 4915 12 expressed express VBN cord-023095-4dannjjm 4915 13 in in IN cord-023095-4dannjjm 4915 14 % % NN cord-023095-4dannjjm 4915 15 of of IN cord-023095-4dannjjm 4915 16 D d NN cord-023095-4dannjjm 4915 17 2 2 CD cord-023095-4dannjjm 4915 18 O o NN cord-023095-4dannjjm 4915 19 Vd vd NN cord-023095-4dannjjm 4915 20 ) ) -RRB- cord-023095-4dannjjm 4915 21 ranged range VBD cord-023095-4dannjjm 4915 22 from from IN cord-023095-4dannjjm 4915 23 À9.5 À9.5 NNP cord-023095-4dannjjm 4915 24 to to IN cord-023095-4dannjjm 4915 25 1.0 1.0 CD cord-023095-4dannjjm 4915 26 % % NN cord-023095-4dannjjm 4915 27 ( ( -LRB- cord-023095-4dannjjm 4915 28 C C NNP cord-023095-4dannjjm 4915 29 ) ) -RRB- cord-023095-4dannjjm 4915 30 and and CC cord-023095-4dannjjm 4915 31 from from IN cord-023095-4dannjjm 4915 32 À17.3 À17.3 NNS cord-023095-4dannjjm 4915 33 to to IN cord-023095-4dannjjm 4915 34 À7.1 À7.1 NNP cord-023095-4dannjjm 4915 35 % % NN cord-023095-4dannjjm 4915 36 ( ( -LRB- cord-023095-4dannjjm 4915 37 O o UH cord-023095-4dannjjm 4915 38 ) ) -RRB- cord-023095-4dannjjm 4915 39 . . . cord-023095-4dannjjm 4916 1 In in IN cord-023095-4dannjjm 4916 2 conclusion conclusion NN cord-023095-4dannjjm 4916 3 , , , cord-023095-4dannjjm 4916 4 creatinine creatinine NN cord-023095-4dannjjm 4916 5 Vd Vd NNP cord-023095-4dannjjm 4916 6 provides provide VBZ cord-023095-4dannjjm 4916 7 a a DT cord-023095-4dannjjm 4916 8 good good JJ cord-023095-4dannjjm 4916 9 estimate estimate NN cord-023095-4dannjjm 4916 10 of of IN cord-023095-4dannjjm 4916 11 D d NN cord-023095-4dannjjm 4916 12 2 2 CD cord-023095-4dannjjm 4916 13 O o NN cord-023095-4dannjjm 4916 14 Vd vd NN cord-023095-4dannjjm 4916 15 in in IN cord-023095-4dannjjm 4916 16 both both CC cord-023095-4dannjjm 4916 17 normal normal JJ cord-023095-4dannjjm 4916 18 and and CC cord-023095-4dannjjm 4916 19 obese obese JJ cord-023095-4dannjjm 4916 20 conditions condition NNS cord-023095-4dannjjm 4916 21 . . . cord-023095-4dannjjm 4917 1 A a DT cord-023095-4dannjjm 4917 2 16 16 CD cord-023095-4dannjjm 4917 3 wk wk NN cord-023095-4dannjjm 4917 4 double double JJ cord-023095-4dannjjm 4917 5 blinded blinded JJ cord-023095-4dannjjm 4917 6 study study NN cord-023095-4dannjjm 4917 7 was be VBD cord-023095-4dannjjm 4917 8 conducted conduct VBN cord-023095-4dannjjm 4917 9 comparing compare VBG cord-023095-4dannjjm 4917 10 the the DT cord-023095-4dannjjm 4917 11 affect affect NN cord-023095-4dannjjm 4917 12 of of IN cord-023095-4dannjjm 4917 13 two two CD cord-023095-4dannjjm 4917 14 foods food NNS cord-023095-4dannjjm 4917 15 on on IN cord-023095-4dannjjm 4917 16 mobility mobility NN cord-023095-4dannjjm 4917 17 in in IN cord-023095-4dannjjm 4917 18 dogs dog NNS cord-023095-4dannjjm 4917 19 . . . cord-023095-4dannjjm 4918 1 All all DT cord-023095-4dannjjm 4918 2 work work NN cord-023095-4dannjjm 4918 3 was be VBD cord-023095-4dannjjm 4918 4 approved approve VBN cord-023095-4dannjjm 4918 5 by by IN cord-023095-4dannjjm 4918 6 an an DT cord-023095-4dannjjm 4918 7 IACUC IACUC NNP cord-023095-4dannjjm 4918 8 . . . cord-023095-4dannjjm 4919 1 53 53 CD cord-023095-4dannjjm 4919 2 healthy healthy JJ cord-023095-4dannjjm 4919 3 beagle beagle NN cord-023095-4dannjjm 4919 4 dogs dog NNS cord-023095-4dannjjm 4919 5 ( ( -LRB- cord-023095-4dannjjm 4919 6 7 7 CD cord-023095-4dannjjm 4919 7 - - SYM cord-023095-4dannjjm 4919 8 15 15 CD cord-023095-4dannjjm 4919 9 years year NNS cord-023095-4dannjjm 4919 10 old old JJ cord-023095-4dannjjm 4919 11 , , , cord-023095-4dannjjm 4919 12 mixed mixed JJ cord-023095-4dannjjm 4919 13 gender gender NN cord-023095-4dannjjm 4919 14 ) ) -RRB- cord-023095-4dannjjm 4919 15 were be VBD cord-023095-4dannjjm 4919 16 used use VBN cord-023095-4dannjjm 4919 17 . . . cord-023095-4dannjjm 4920 1 33 33 CD cord-023095-4dannjjm 4920 2 affected affected JJ cord-023095-4dannjjm 4920 3 ( ( -LRB- cord-023095-4dannjjm 4920 4 A a NN cord-023095-4dannjjm 4920 5 ) ) -RRB- cord-023095-4dannjjm 4920 6 and and CC cord-023095-4dannjjm 4920 7 20 20 CD cord-023095-4dannjjm 4920 8 non non JJ cord-023095-4dannjjm 4920 9 - - JJ cord-023095-4dannjjm 4920 10 affected affected JJ cord-023095-4dannjjm 4920 11 ( ( -LRB- cord-023095-4dannjjm 4920 12 NA NA NNP cord-023095-4dannjjm 4920 13 ) ) -RRB- cord-023095-4dannjjm 4920 14 dogs dog NNS cord-023095-4dannjjm 4920 15 were be VBD cord-023095-4dannjjm 4920 16 identified identify VBN cord-023095-4dannjjm 4920 17 based base VBN cord-023095-4dannjjm 4920 18 on on IN cord-023095-4dannjjm 4920 19 orthopedic orthopedic JJ cord-023095-4dannjjm 4920 20 examination examination NN cord-023095-4dannjjm 4920 21 and and CC cord-023095-4dannjjm 4920 22 radiography radiography NN cord-023095-4dannjjm 4920 23 as as IN cord-023095-4dannjjm 4920 24 having have VBG cord-023095-4dannjjm 4920 25 or or CC cord-023095-4dannjjm 4920 26 not not RB cord-023095-4dannjjm 4920 27 having have VBG cord-023095-4dannjjm 4920 28 evidence evidence NN cord-023095-4dannjjm 4920 29 of of IN cord-023095-4dannjjm 4920 30 naturally naturally RB cord-023095-4dannjjm 4920 31 occurring occur VBG cord-023095-4dannjjm 4920 32 joint joint JJ cord-023095-4dannjjm 4920 33 pathology pathology NN cord-023095-4dannjjm 4920 34 ( ( -LRB- cord-023095-4dannjjm 4920 35 presence presence NN cord-023095-4dannjjm 4920 36 of of IN cord-023095-4dannjjm 4920 37 osteophytes osteophytes NNP cord-023095-4dannjjm 4920 38 , , , cord-023095-4dannjjm 4920 39 dysplasia dysplasia NN cord-023095-4dannjjm 4920 40 , , , cord-023095-4dannjjm 4920 41 effusion effusion NN cord-023095-4dannjjm 4920 42 , , , cord-023095-4dannjjm 4920 43 pain pain NN cord-023095-4dannjjm 4920 44 on on IN cord-023095-4dannjjm 4920 45 manipulation manipulation NN cord-023095-4dannjjm 4920 46 etc etc NN cord-023095-4dannjjm 4920 47 ) ) -RRB- cord-023095-4dannjjm 4920 48 in in IN cord-023095-4dannjjm 4920 49 one one CD cord-023095-4dannjjm 4920 50 or or CC cord-023095-4dannjjm 4920 51 more more JJR cord-023095-4dannjjm 4920 52 joints joint NNS cord-023095-4dannjjm 4920 53 . . . cord-023095-4dannjjm 4921 1 A a NN cord-023095-4dannjjm 4921 2 and and CC cord-023095-4dannjjm 4921 3 NA NA NNP cord-023095-4dannjjm 4921 4 dogs dog NNS cord-023095-4dannjjm 4921 5 were be VBD cord-023095-4dannjjm 4921 6 evenly evenly RB cord-023095-4dannjjm 4921 7 distributed distribute VBN cord-023095-4dannjjm 4921 8 between between IN cord-023095-4dannjjm 4921 9 two two CD cord-023095-4dannjjm 4921 10 locations location NNS cord-023095-4dannjjm 4921 11 . . . cord-023095-4dannjjm 4922 1 Foods food NNS cord-023095-4dannjjm 4922 2 had have VBD cord-023095-4dannjjm 4922 3 nutrient nutrient NN cord-023095-4dannjjm 4922 4 profiles profile NNS cord-023095-4dannjjm 4922 5 adequate adequate JJ cord-023095-4dannjjm 4922 6 for for IN cord-023095-4dannjjm 4922 7 maintenance maintenance NN cord-023095-4dannjjm 4922 8 according accord VBG cord-023095-4dannjjm 4922 9 to to IN cord-023095-4dannjjm 4922 10 the the DT cord-023095-4dannjjm 4922 11 2009 2009 CD cord-023095-4dannjjm 4922 12 AAFCO AAFCO NNP cord-023095-4dannjjm 4922 13 Official Official NNP cord-023095-4dannjjm 4922 14 Publication Publication NNP cord-023095-4dannjjm 4922 15 . . . cord-023095-4dannjjm 4923 1 The the DT cord-023095-4dannjjm 4923 2 Test test NN cord-023095-4dannjjm 4923 3 food food NN cord-023095-4dannjjm 4923 4 contained contain VBD cord-023095-4dannjjm 4923 5 greater great JJR cord-023095-4dannjjm 4923 6 amounts amount NNS cord-023095-4dannjjm 4923 7 of of IN cord-023095-4dannjjm 4923 8 methionine methionine NN cord-023095-4dannjjm 4923 9 , , , cord-023095-4dannjjm 4923 10 manganese manganese NN cord-023095-4dannjjm 4923 11 , , , cord-023095-4dannjjm 4923 12 carnitine carnitine NN cord-023095-4dannjjm 4923 13 , , , cord-023095-4dannjjm 4923 14 vit vit NNP cord-023095-4dannjjm 4923 15 . . . cord-023095-4dannjjm 4924 1 E E NNP cord-023095-4dannjjm 4924 2 , , , cord-023095-4dannjjm 4924 3 , , , cord-023095-4dannjjm 4924 4 vit vit NNP cord-023095-4dannjjm 4924 5 . . . cord-023095-4dannjjm 4925 1 C C NNP cord-023095-4dannjjm 4925 2 , , , cord-023095-4dannjjm 4925 3 alpha alpha NN cord-023095-4dannjjm 4925 4 linolenic linolenic NN cord-023095-4dannjjm 4925 5 acid acid NN cord-023095-4dannjjm 4925 6 ( ( -LRB- cord-023095-4dannjjm 4925 7 ALA ALA NNP cord-023095-4dannjjm 4925 8 ) ) -RRB- cord-023095-4dannjjm 4925 9 , , , cord-023095-4dannjjm 4925 10 and and CC cord-023095-4dannjjm 4925 11 eicosapentaenoic eicosapentaenoic JJ cord-023095-4dannjjm 4925 12 ( ( -LRB- cord-023095-4dannjjm 4925 13 EPA EPA NNP cord-023095-4dannjjm 4925 14 ) ) -RRB- cord-023095-4dannjjm 4925 15 acid acid NN cord-023095-4dannjjm 4925 16 : : : cord-023095-4dannjjm 4925 17 the the DT cord-023095-4dannjjm 4925 18 food food NN cord-023095-4dannjjm 4925 19 provided provide VBD cord-023095-4dannjjm 4925 20 388 388 CD cord-023095-4dannjjm 4925 21 mg mg NN cord-023095-4dannjjm 4925 22 n3 n3 NN cord-023095-4dannjjm 4925 23 fatty fatty JJ cord-023095-4dannjjm 4925 24 acids acid NNS cord-023095-4dannjjm 4925 25 and and CC cord-023095-4dannjjm 4925 26 847 847 CD cord-023095-4dannjjm 4925 27 mg mg NN cord-023095-4dannjjm 4925 28 n6 n6 NNP cord-023095-4dannjjm 4925 29 fatty fatty JJ cord-023095-4dannjjm 4925 30 acids acid NNS cord-023095-4dannjjm 4925 31 per per IN cord-023095-4dannjjm 4925 32 100kcal 100kcal CD cord-023095-4dannjjm 4925 33 . . . cord-023095-4dannjjm 4926 1 All all DT cord-023095-4dannjjm 4926 2 dogs dog NNS cord-023095-4dannjjm 4926 3 were be VBD cord-023095-4dannjjm 4926 4 fed feed VBN cord-023095-4dannjjm 4926 5 the the DT cord-023095-4dannjjm 4926 6 Control Control NNP cord-023095-4dannjjm 4926 7 food food NN cord-023095-4dannjjm 4926 8 for for IN cord-023095-4dannjjm 4926 9 4 4 CD cord-023095-4dannjjm 4926 10 wks wks NN cord-023095-4dannjjm 4926 11 followed follow VBN cord-023095-4dannjjm 4926 12 by by IN cord-023095-4dannjjm 4926 13 a a DT cord-023095-4dannjjm 4926 14 12 12 CD cord-023095-4dannjjm 4926 15 wk wk NN cord-023095-4dannjjm 4926 16 feeding feeding NN cord-023095-4dannjjm 4926 17 period period NN cord-023095-4dannjjm 4926 18 where where WRB cord-023095-4dannjjm 4926 19 17 17 CD cord-023095-4dannjjm 4926 20 A a NN cord-023095-4dannjjm 4926 21 and and CC cord-023095-4dannjjm 4926 22 10 10 CD cord-023095-4dannjjm 4926 23 NA NA NNP cord-023095-4dannjjm 4926 24 dogs dog NNS cord-023095-4dannjjm 4926 25 consumed consume VBD cord-023095-4dannjjm 4926 26 the the DT cord-023095-4dannjjm 4926 27 Test test NN cord-023095-4dannjjm 4926 28 food food NN cord-023095-4dannjjm 4926 29 and and CC cord-023095-4dannjjm 4926 30 16 16 CD cord-023095-4dannjjm 4926 31 A a NN cord-023095-4dannjjm 4926 32 and and CC cord-023095-4dannjjm 4926 33 10 10 CD cord-023095-4dannjjm 4926 34 NA NA NNP cord-023095-4dannjjm 4926 35 dogs dog NNS cord-023095-4dannjjm 4926 36 the the DT cord-023095-4dannjjm 4926 37 Control Control NNP cord-023095-4dannjjm 4926 38 . . . cord-023095-4dannjjm 4927 1 Blood blood NN cord-023095-4dannjjm 4927 2 and and CC cord-023095-4dannjjm 4927 3 urine urine NN cord-023095-4dannjjm 4927 4 were be VBD cord-023095-4dannjjm 4927 5 collected collect VBN cord-023095-4dannjjm 4927 6 at at IN cord-023095-4dannjjm 4927 7 weeks week NNS cord-023095-4dannjjm 4927 8 0 0 CD cord-023095-4dannjjm 4927 9 , , , cord-023095-4dannjjm 4927 10 4 4 CD cord-023095-4dannjjm 4927 11 , , , cord-023095-4dannjjm 4927 12 8 8 CD cord-023095-4dannjjm 4927 13 and and CC cord-023095-4dannjjm 4927 14 12 12 CD cord-023095-4dannjjm 4927 15 and and CC cord-023095-4dannjjm 4927 16 analyzed analyze VBD cord-023095-4dannjjm 4927 17 for for IN cord-023095-4dannjjm 4927 18 serum serum NN cord-023095-4dannjjm 4927 19 fatty fatty JJ cord-023095-4dannjjm 4927 20 acids acid NNS cord-023095-4dannjjm 4927 21 and and CC cord-023095-4dannjjm 4927 22 urine urine NN cord-023095-4dannjjm 4927 23 thromboxane thromboxane NN cord-023095-4dannjjm 4927 24 : : : cord-023095-4dannjjm 4927 25 creatinine creatinine NN cord-023095-4dannjjm 4927 26 ratios ratio NNS cord-023095-4dannjjm 4927 27 were be VBD cord-023095-4dannjjm 4927 28 determined determine VBN cord-023095-4dannjjm 4927 29 . . . cord-023095-4dannjjm 4928 1 Evaluators evaluator NNS cord-023095-4dannjjm 4928 2 in in IN cord-023095-4dannjjm 4928 3 this this DT cord-023095-4dannjjm 4928 4 study study NN cord-023095-4dannjjm 4928 5 were be VBD cord-023095-4dannjjm 4928 6 different different JJ cord-023095-4dannjjm 4928 7 than than IN cord-023095-4dannjjm 4928 8 those those DT cord-023095-4dannjjm 4928 9 making make VBG cord-023095-4dannjjm 4928 10 the the DT cord-023095-4dannjjm 4928 11 original original JJ cord-023095-4dannjjm 4928 12 diagnosis diagnosis NN cord-023095-4dannjjm 4928 13 and and CC cord-023095-4dannjjm 4928 14 so so RB cord-023095-4dannjjm 4928 15 were be VBD cord-023095-4dannjjm 4928 16 blinded blind VBN cord-023095-4dannjjm 4928 17 as as IN cord-023095-4dannjjm 4928 18 to to IN cord-023095-4dannjjm 4928 19 treatment treatment NN cord-023095-4dannjjm 4928 20 and and CC cord-023095-4dannjjm 4928 21 diagnosis diagnosis NN cord-023095-4dannjjm 4928 22 . . . cord-023095-4dannjjm 4929 1 Orthopedic orthopedic NN cord-023095-4dannjjm 4929 2 exams exam NNS cord-023095-4dannjjm 4929 3 were be VBD cord-023095-4dannjjm 4929 4 performed perform VBN cord-023095-4dannjjm 4929 5 by by IN cord-023095-4dannjjm 4929 6 two two CD cord-023095-4dannjjm 4929 7 veterinary veterinary JJ cord-023095-4dannjjm 4929 8 surgeons surgeon NNS cord-023095-4dannjjm 4929 9 at at IN cord-023095-4dannjjm 4929 10 each each DT cord-023095-4dannjjm 4929 11 site site NN cord-023095-4dannjjm 4929 12 on on IN cord-023095-4dannjjm 4929 13 weeks week NNS cord-023095-4dannjjm 4929 14 0 0 CD cord-023095-4dannjjm 4929 15 , , , cord-023095-4dannjjm 4929 16 4 4 CD cord-023095-4dannjjm 4929 17 , , , cord-023095-4dannjjm 4929 18 8 8 CD cord-023095-4dannjjm 4929 19 and and CC cord-023095-4dannjjm 4929 20 12 12 CD cord-023095-4dannjjm 4929 21 . . . cord-023095-4dannjjm 4930 1 The the DT cord-023095-4dannjjm 4930 2 same same JJ cord-023095-4dannjjm 4930 3 two two CD cord-023095-4dannjjm 4930 4 evaluators evaluator NNS cord-023095-4dannjjm 4930 5 examined examine VBD cord-023095-4dannjjm 4930 6 the the DT cord-023095-4dannjjm 4930 7 same same JJ cord-023095-4dannjjm 4930 8 dogs dog NNS cord-023095-4dannjjm 4930 9 throughout throughout RB cord-023095-4dannjjm 4930 10 . . . cord-023095-4dannjjm 4931 1 The the DT cord-023095-4dannjjm 4931 2 data datum NNS cord-023095-4dannjjm 4931 3 was be VBD cord-023095-4dannjjm 4931 4 evaluated evaluate VBN cord-023095-4dannjjm 4931 5 for for IN cord-023095-4dannjjm 4931 6 the the DT cord-023095-4dannjjm 4931 7 difference difference NN cord-023095-4dannjjm 4931 8 between between IN cord-023095-4dannjjm 4931 9 A a NN cord-023095-4dannjjm 4931 10 and and CC cord-023095-4dannjjm 4931 11 NA NA NNP cord-023095-4dannjjm 4931 12 dogs dog NNS cord-023095-4dannjjm 4931 13 and and CC cord-023095-4dannjjm 4931 14 between between IN cord-023095-4dannjjm 4931 15 foods food NNS cord-023095-4dannjjm 4931 16 with with IN cord-023095-4dannjjm 4931 17 age age NN cord-023095-4dannjjm 4931 18 , , , cord-023095-4dannjjm 4931 19 gender gender NN cord-023095-4dannjjm 4931 20 and and CC cord-023095-4dannjjm 4931 21 location location NN cord-023095-4dannjjm 4931 22 as as IN cord-023095-4dannjjm 4931 23 covariates covariate NNS cord-023095-4dannjjm 4931 24 . . . cord-023095-4dannjjm 4932 1 Body body NN cord-023095-4dannjjm 4932 2 weight weight NN cord-023095-4dannjjm 4932 3 , , , cord-023095-4dannjjm 4932 4 disease disease NN cord-023095-4dannjjm 4932 5 status status NN cord-023095-4dannjjm 4932 6 , , , cord-023095-4dannjjm 4932 7 age age NN cord-023095-4dannjjm 4932 8 and and CC cord-023095-4dannjjm 4932 9 gender gender NN cord-023095-4dannjjm 4932 10 were be VBD cord-023095-4dannjjm 4932 11 blocked block VBN cord-023095-4dannjjm 4932 12 . . . cord-023095-4dannjjm 4933 1 Analysis analysis NN cord-023095-4dannjjm 4933 2 included include VBD cord-023095-4dannjjm 4933 3 ANOVA ANOVA NNP cord-023095-4dannjjm 4933 4 repeated repeat VBD cord-023095-4dannjjm 4933 5 measures measure NNS cord-023095-4dannjjm 4933 6 mixed mixed JJ cord-023095-4dannjjm 4933 7 procedure procedure NN cord-023095-4dannjjm 4933 8 ( ( -LRB- cord-023095-4dannjjm 4933 9 SAS SAS NNP cord-023095-4dannjjm 4933 10 version version NN cord-023095-4dannjjm 4933 11 9.0 9.0 CD cord-023095-4dannjjm 4933 12 ) ) -RRB- cord-023095-4dannjjm 4933 13 to to TO cord-023095-4dannjjm 4933 14 determine determine VB cord-023095-4dannjjm 4933 15 treatment treatment NN cord-023095-4dannjjm 4933 16 effects effect NNS cord-023095-4dannjjm 4933 17 over over IN cord-023095-4dannjjm 4933 18 time time NN cord-023095-4dannjjm 4933 19 . . . cord-023095-4dannjjm 4934 1 Serum serum NN cord-023095-4dannjjm 4934 2 EPA EPA NNP cord-023095-4dannjjm 4934 3 was be VBD cord-023095-4dannjjm 4934 4 greater great JJR cord-023095-4dannjjm 4934 5 and and CC cord-023095-4dannjjm 4934 6 arachidonic arachidonic JJ cord-023095-4dannjjm 4934 7 acid acid NN cord-023095-4dannjjm 4934 8 lower lower RBR cord-023095-4dannjjm 4934 9 at at IN cord-023095-4dannjjm 4934 10 weeks week NNS cord-023095-4dannjjm 4934 11 4 4 CD cord-023095-4dannjjm 4934 12 , , , cord-023095-4dannjjm 4934 13 8 8 CD cord-023095-4dannjjm 4934 14 and and CC cord-023095-4dannjjm 4934 15 12 12 CD cord-023095-4dannjjm 4934 16 in in IN cord-023095-4dannjjm 4934 17 the the DT cord-023095-4dannjjm 4934 18 Test test NN cord-023095-4dannjjm 4934 19 food food NN cord-023095-4dannjjm 4934 20 fed feed VBD cord-023095-4dannjjm 4934 21 dogs dog NNS cord-023095-4dannjjm 4934 22 ( ( -LRB- cord-023095-4dannjjm 4934 23 p p NN cord-023095-4dannjjm 4934 24 o o NN cord-023095-4dannjjm 4934 25 0.05 0.05 CD cord-023095-4dannjjm 4934 26 ) ) -RRB- cord-023095-4dannjjm 4934 27 . . . cord-023095-4dannjjm 4935 1 Urine Urine NNP cord-023095-4dannjjm 4935 2 thromboxane thromboxane NN cord-023095-4dannjjm 4935 3 : : : cord-023095-4dannjjm 4936 1 creatinine creatinine NN cord-023095-4dannjjm 4936 2 ratios ratio NNS cord-023095-4dannjjm 4936 3 were be VBD cord-023095-4dannjjm 4936 4 decreased decrease VBN cord-023095-4dannjjm 4936 5 in in IN cord-023095-4dannjjm 4936 6 the the DT cord-023095-4dannjjm 4936 7 A A NNP cord-023095-4dannjjm 4936 8 dogs dog NNS cord-023095-4dannjjm 4936 9 fed feed VBD cord-023095-4dannjjm 4936 10 the the DT cord-023095-4dannjjm 4936 11 Test test NN cord-023095-4dannjjm 4936 12 food food NN cord-023095-4dannjjm 4936 13 compared compare VBN cord-023095-4dannjjm 4936 14 to to IN cord-023095-4dannjjm 4936 15 the the DT cord-023095-4dannjjm 4936 16 A A NNP cord-023095-4dannjjm 4936 17 dogs dog NNS cord-023095-4dannjjm 4936 18 fed feed VBD cord-023095-4dannjjm 4936 19 the the DT cord-023095-4dannjjm 4936 20 Control Control NNP cord-023095-4dannjjm 4936 21 food food NN cord-023095-4dannjjm 4936 22 at at IN cord-023095-4dannjjm 4936 23 12 12 CD cord-023095-4dannjjm 4936 24 wks wks NN cord-023095-4dannjjm 4937 1 ( ( -LRB- cord-023095-4dannjjm 4937 2 p p NN cord-023095-4dannjjm 4937 3 o o NN cord-023095-4dannjjm 4937 4 0.05 0.05 CD cord-023095-4dannjjm 4937 5 ) ) -RRB- cord-023095-4dannjjm 4937 6 . . . cord-023095-4dannjjm 4938 1 Lameness lameness NN cord-023095-4dannjjm 4938 2 score score NN cord-023095-4dannjjm 4938 3 was be VBD cord-023095-4dannjjm 4938 4 significantly significantly RB cord-023095-4dannjjm 4938 5 improved improve VBN cord-023095-4dannjjm 4938 6 ( ( -LRB- cord-023095-4dannjjm 4938 7 p p NN cord-023095-4dannjjm 4938 8 o o NN cord-023095-4dannjjm 4938 9 0.05 0.05 CD cord-023095-4dannjjm 4938 10 ) ) -RRB- cord-023095-4dannjjm 4938 11 within within IN cord-023095-4dannjjm 4938 12 and and CC cord-023095-4dannjjm 4938 13 between between IN cord-023095-4dannjjm 4938 14 groups group NNS cord-023095-4dannjjm 4938 15 of of IN cord-023095-4dannjjm 4938 16 dogs dog NNS cord-023095-4dannjjm 4938 17 fed feed VBD cord-023095-4dannjjm 4938 18 the the DT cord-023095-4dannjjm 4938 19 Test test NN cord-023095-4dannjjm 4938 20 food food NN cord-023095-4dannjjm 4938 21 . . . cord-023095-4dannjjm 4939 1 A a DT cord-023095-4dannjjm 4939 2 significantly significantly RB cord-023095-4dannjjm 4939 3 greater great JJR cord-023095-4dannjjm 4939 4 proportion proportion NN cord-023095-4dannjjm 4939 5 of of IN cord-023095-4dannjjm 4939 6 A a DT cord-023095-4dannjjm 4939 7 dogs dog NNS cord-023095-4dannjjm 4939 8 fed feed VBD cord-023095-4dannjjm 4939 9 the the DT cord-023095-4dannjjm 4939 10 Test test NN cord-023095-4dannjjm 4939 11 food food NN cord-023095-4dannjjm 4939 12 had have VBD cord-023095-4dannjjm 4939 13 improvement improvement NN cord-023095-4dannjjm 4939 14 in in IN cord-023095-4dannjjm 4939 15 total total JJ cord-023095-4dannjjm 4939 16 _SP cord-023095-4dannjjm 4939 17 Het Het NNP cord-023095-4dannjjm 4939 18 ( ( -LRB- cord-023095-4dannjjm 4939 19 n511 n511 NNP cord-023095-4dannjjm 4939 20 ) ) -RRB- cord-023095-4dannjjm 4939 21 Blood blood NN cord-023095-4dannjjm 4939 22 glucose glucose NN cord-023095-4dannjjm 4939 23 ( ( -LRB- cord-023095-4dannjjm 4939 24 mg mg NNP cord-023095-4dannjjm 4939 25 / / SYM cord-023095-4dannjjm 4939 26 dL dl NN cord-023095-4dannjjm 4939 27 ) ) -RRB- cord-023095-4dannjjm 4939 28 78 78 CD cord-023095-4dannjjm 4940 1 ( ( -LRB- cord-023095-4dannjjm 4940 2 AE17 AE17 NNP cord-023095-4dannjjm 4940 3 ) ) -RRB- cord-023095-4dannjjm 4940 4 64 64 CD cord-023095-4dannjjm 4941 1 ( ( -LRB- cord-023095-4dannjjm 4941 2 AE13 AE13 NNP cord-023095-4dannjjm 4941 3 ) ) -RRB- cord-023095-4dannjjm 4941 4 Blood blood NN cord-023095-4dannjjm 4941 5 lactate lactate NN cord-023095-4dannjjm 4941 6 ( ( -LRB- cord-023095-4dannjjm 4941 7 mmol mmol NNP cord-023095-4dannjjm 4941 8 / / SYM cord-023095-4dannjjm 4941 9 L l NN cord-023095-4dannjjm 4941 10 ) ) -RRB- cord-023095-4dannjjm 4941 11 1.1 1.1 CD cord-023095-4dannjjm 4941 12 ( ( -LRB- cord-023095-4dannjjm 4941 13 AE0.5 AE0.5 NNP cord-023095-4dannjjm 4941 14 ) ) -RRB- cord-023095-4dannjjm 4941 15 1.7 1.7 CD cord-023095-4dannjjm 4941 16 ( ( -LRB- cord-023095-4dannjjm 4941 17 AE1.1 AE1.1 NNP cord-023095-4dannjjm 4941 18 ) ) -RRB- cord-023095-4dannjjm 4941 19 joint joint JJ cord-023095-4dannjjm 4941 20 score score NN cord-023095-4dannjjm 4941 21 , , , cord-023095-4dannjjm 4941 22 lameness lameness NN cord-023095-4dannjjm 4941 23 , , , cord-023095-4dannjjm 4941 24 functional functional JJ cord-023095-4dannjjm 4941 25 disability disability NN cord-023095-4dannjjm 4941 26 and and CC cord-023095-4dannjjm 4941 27 overall overall JJ cord-023095-4dannjjm 4941 28 assessment assessment NN cord-023095-4dannjjm 4941 29 score score NN cord-023095-4dannjjm 4941 30 at at IN cord-023095-4dannjjm 4941 31 12 12 CD cord-023095-4dannjjm 4941 32 wks wks NN cord-023095-4dannjjm 4941 33 compared compare VBN cord-023095-4dannjjm 4941 34 to to IN cord-023095-4dannjjm 4941 35 A a DT cord-023095-4dannjjm 4941 36 dogs dog NNS cord-023095-4dannjjm 4941 37 fed feed VBD cord-023095-4dannjjm 4941 38 the the DT cord-023095-4dannjjm 4941 39 Control Control NNP cord-023095-4dannjjm 4941 40 food food NN cord-023095-4dannjjm 4941 41 . . . cord-023095-4dannjjm 4942 1 69 69 CD cord-023095-4dannjjm 4942 2 % % NN cord-023095-4dannjjm 4942 3 of of IN cord-023095-4dannjjm 4942 4 A a DT cord-023095-4dannjjm 4942 5 dogs dog NNS cord-023095-4dannjjm 4942 6 had have VBD cord-023095-4dannjjm 4942 7 an an DT cord-023095-4dannjjm 4942 8 improved improve VBN cord-023095-4dannjjm 4942 9 Overall Overall NNP cord-023095-4dannjjm 4942 10 Assessment Assessment NNP cord-023095-4dannjjm 4942 11 score score NN cord-023095-4dannjjm 4942 12 on on IN cord-023095-4dannjjm 4942 13 the the DT cord-023095-4dannjjm 4942 14 Test test NN cord-023095-4dannjjm 4942 15 food food NN cord-023095-4dannjjm 4942 16 after after IN cord-023095-4dannjjm 4942 17 4 4 CD cord-023095-4dannjjm 4942 18 wks wks NN cord-023095-4dannjjm 4942 19 and and CC cord-023095-4dannjjm 4942 20 at at IN cord-023095-4dannjjm 4942 21 12 12 CD cord-023095-4dannjjm 4942 22 wks wks NN cord-023095-4dannjjm 4942 23 compared compare VBN cord-023095-4dannjjm 4942 24 to to IN cord-023095-4dannjjm 4942 25 40 40 CD cord-023095-4dannjjm 4942 26 % % NN cord-023095-4dannjjm 4942 27 at at IN cord-023095-4dannjjm 4942 28 4 4 CD cord-023095-4dannjjm 4942 29 wks wks NN cord-023095-4dannjjm 4942 30 and and CC cord-023095-4dannjjm 4942 31 27 27 CD cord-023095-4dannjjm 4942 32 % % NN cord-023095-4dannjjm 4942 33 at at IN cord-023095-4dannjjm 4942 34 12 12 CD cord-023095-4dannjjm 4942 35 wks wks NN cord-023095-4dannjjm 4942 36 of of IN cord-023095-4dannjjm 4942 37 A a DT cord-023095-4dannjjm 4942 38 dogs dog NNS cord-023095-4dannjjm 4942 39 consuming consume VBG cord-023095-4dannjjm 4942 40 the the DT cord-023095-4dannjjm 4942 41 Control Control NNP cord-023095-4dannjjm 4942 42 food food NN cord-023095-4dannjjm 4942 43 . . . cord-023095-4dannjjm 4943 1 This this DT cord-023095-4dannjjm 4943 2 study study NN cord-023095-4dannjjm 4943 3 shows show VBZ cord-023095-4dannjjm 4943 4 that that IN cord-023095-4dannjjm 4943 5 a a DT cord-023095-4dannjjm 4943 6 food food NN cord-023095-4dannjjm 4943 7 with with IN cord-023095-4dannjjm 4943 8 moderate moderate JJ cord-023095-4dannjjm 4943 9 amounts amount NNS cord-023095-4dannjjm 4943 10 of of IN cord-023095-4dannjjm 4943 11 added add VBN cord-023095-4dannjjm 4943 12 linolenic linolenic JJ cord-023095-4dannjjm 4943 13 acid acid NN cord-023095-4dannjjm 4943 14 and and CC cord-023095-4dannjjm 4943 15 EPA EPA NNP cord-023095-4dannjjm 4943 16 can can MD cord-023095-4dannjjm 4943 17 have have VB cord-023095-4dannjjm 4943 18 a a DT cord-023095-4dannjjm 4943 19 positive positive JJ cord-023095-4dannjjm 4943 20 impact impact NN cord-023095-4dannjjm 4943 21 on on IN cord-023095-4dannjjm 4943 22 systemic systemic JJ cord-023095-4dannjjm 4943 23 inflammation inflammation NN cord-023095-4dannjjm 4943 24 and and CC cord-023095-4dannjjm 4943 25 mobility mobility NN cord-023095-4dannjjm 4943 26 in in IN cord-023095-4dannjjm 4943 27 4 4 CD cord-023095-4dannjjm 4943 28 - - SYM cord-023095-4dannjjm 4943 29 12 12 CD cord-023095-4dannjjm 4943 30 weeks week NNS cord-023095-4dannjjm 4943 31 . . . cord-023095-4dannjjm 4944 1 A a DT cord-023095-4dannjjm 4944 2 similar similar JJ cord-023095-4dannjjm 4944 3 abstract abstract NN cord-023095-4dannjjm 4944 4 will will MD cord-023095-4dannjjm 4944 5 be be VB cord-023095-4dannjjm 4944 6 presented present VBN cord-023095-4dannjjm 4944 7 at at IN cord-023095-4dannjjm 4944 8 the the DT cord-023095-4dannjjm 4944 9 Orthopedic Orthopedic NNP cord-023095-4dannjjm 4944 10 Research Research NNP cord-023095-4dannjjm 4944 11 Society Society NNP cord-023095-4dannjjm 4944 12 meeting meeting NN cord-023095-4dannjjm 4944 13 in in IN cord-023095-4dannjjm 4944 14 January January NNP cord-023095-4dannjjm 4944 15 2011 2011 CD cord-023095-4dannjjm 4944 16 to to IN cord-023095-4dannjjm 4944 17 an an DT cord-023095-4dannjjm 4944 18 audience audience NN cord-023095-4dannjjm 4944 19 largely largely RB cord-023095-4dannjjm 4944 20 of of IN cord-023095-4dannjjm 4944 21 orthopedic orthopedic JJ cord-023095-4dannjjm 4944 22 researchers researcher NNS cord-023095-4dannjjm 4944 23 interested interested JJ cord-023095-4dannjjm 4944 24 in in IN cord-023095-4dannjjm 4944 25 human human JJ cord-023095-4dannjjm 4944 26 orthopedics orthopedic NNS cord-023095-4dannjjm 4944 27 . . . cord-023095-4dannjjm 4945 1 Fat fat NN cord-023095-4dannjjm 4945 2 is be VBZ cord-023095-4dannjjm 4945 3 an an DT cord-023095-4dannjjm 4945 4 important important JJ cord-023095-4dannjjm 4945 5 dietary dietary JJ cord-023095-4dannjjm 4945 6 component component NN cord-023095-4dannjjm 4945 7 , , , cord-023095-4dannjjm 4945 8 serving serve VBG cord-023095-4dannjjm 4945 9 both both DT cord-023095-4dannjjm 4945 10 as as IN cord-023095-4dannjjm 4945 11 a a DT cord-023095-4dannjjm 4945 12 source source NN cord-023095-4dannjjm 4945 13 of of IN cord-023095-4dannjjm 4945 14 energy energy NN cord-023095-4dannjjm 4945 15 and and CC cord-023095-4dannjjm 4945 16 as as IN cord-023095-4dannjjm 4945 17 a a DT cord-023095-4dannjjm 4945 18 supplier supplier NN cord-023095-4dannjjm 4945 19 of of IN cord-023095-4dannjjm 4945 20 essential essential JJ cord-023095-4dannjjm 4945 21 fatty fatty JJ cord-023095-4dannjjm 4945 22 acids acid NNS cord-023095-4dannjjm 4945 23 ( ( -LRB- cord-023095-4dannjjm 4945 24 FA FA NNP cord-023095-4dannjjm 4945 25 ) ) -RRB- cord-023095-4dannjjm 4945 26 . . . cord-023095-4dannjjm 4946 1 Medium medium NN cord-023095-4dannjjm 4946 2 - - HYPH cord-023095-4dannjjm 4946 3 chain chain NN cord-023095-4dannjjm 4946 4 triglycerides triglyceride NNS cord-023095-4dannjjm 4946 5 ( ( -LRB- cord-023095-4dannjjm 4946 6 MCT MCT NNP cord-023095-4dannjjm 4946 7 ) ) -RRB- cord-023095-4dannjjm 4946 8 contain contain VBP cord-023095-4dannjjm 4946 9 intermediate intermediate JJ cord-023095-4dannjjm 4946 10 length length NN cord-023095-4dannjjm 4946 11 FA FA NNP cord-023095-4dannjjm 4946 12 that that WDT cord-023095-4dannjjm 4946 13 do do VBP cord-023095-4dannjjm 4946 14 not not RB cord-023095-4dannjjm 4946 15 rely rely VB cord-023095-4dannjjm 4946 16 on on IN cord-023095-4dannjjm 4946 17 L l NN cord-023095-4dannjjm 4946 18 - - HYPH cord-023095-4dannjjm 4946 19 carnitine carnitine NN cord-023095-4dannjjm 4946 20 for for IN cord-023095-4dannjjm 4946 21 transport transport NN cord-023095-4dannjjm 4946 22 across across IN cord-023095-4dannjjm 4946 23 the the DT cord-023095-4dannjjm 4946 24 inner inner JJ cord-023095-4dannjjm 4946 25 mitochondrial mitochondrial NN cord-023095-4dannjjm 4946 26 membrane membrane NN cord-023095-4dannjjm 4946 27 , , , cord-023095-4dannjjm 4946 28 bypassing bypass VBG cord-023095-4dannjjm 4946 29 this this DT cord-023095-4dannjjm 4946 30 rate rate NN cord-023095-4dannjjm 4946 31 - - HYPH cord-023095-4dannjjm 4946 32 limiting limit VBG cord-023095-4dannjjm 4946 33 step step NN cord-023095-4dannjjm 4946 34 in in IN cord-023095-4dannjjm 4946 35 FA FA NNP cord-023095-4dannjjm 4946 36 oxidation oxidation NN cord-023095-4dannjjm 4946 37 . . . cord-023095-4dannjjm 4947 1 Longchain Longchain NNP cord-023095-4dannjjm 4947 2 ( ( -LRB- cord-023095-4dannjjm 4947 3 n-3 n-3 NN cord-023095-4dannjjm 4947 4 ) ) -RRB- cord-023095-4dannjjm 4947 5 polyunsaturated polyunsaturated JJ cord-023095-4dannjjm 4947 6 fatty fatty JJ cord-023095-4dannjjm 4947 7 acids acid NNS cord-023095-4dannjjm 4947 8 ( ( -LRB- cord-023095-4dannjjm 4947 9 PUFA PUFA NNP cord-023095-4dannjjm 4947 10 ) ) -RRB- cord-023095-4dannjjm 4947 11 from from IN cord-023095-4dannjjm 4947 12 fish fish NN cord-023095-4dannjjm 4947 13 oil oil NN cord-023095-4dannjjm 4947 14 ( ( -LRB- cord-023095-4dannjjm 4947 15 FO FO NNP cord-023095-4dannjjm 4947 16 ) ) -RRB- cord-023095-4dannjjm 4947 17 , , , cord-023095-4dannjjm 4947 18 and and CC cord-023095-4dannjjm 4947 19 in in IN cord-023095-4dannjjm 4947 20 particular particular JJ cord-023095-4dannjjm 4947 21 eicosanoids eicosanoid NNS cord-023095-4dannjjm 4947 22 derived derive VBN cord-023095-4dannjjm 4947 23 from from IN cord-023095-4dannjjm 4947 24 eicosapentaenoic eicosapentaenoic JJ cord-023095-4dannjjm 4947 25 acid acid NN cord-023095-4dannjjm 4947 26 ( ( -LRB- cord-023095-4dannjjm 4947 27 EPA EPA NNP cord-023095-4dannjjm 4947 28 ) ) -RRB- cord-023095-4dannjjm 4947 29 , , , cord-023095-4dannjjm 4947 30 may may MD cord-023095-4dannjjm 4947 31 protect protect VB cord-023095-4dannjjm 4947 32 against against IN cord-023095-4dannjjm 4947 33 excessive excessive JJ cord-023095-4dannjjm 4947 34 inflammatory inflammatory JJ cord-023095-4dannjjm 4947 35 reactions reaction NNS cord-023095-4dannjjm 4947 36 , , , cord-023095-4dannjjm 4947 37 which which WDT cord-023095-4dannjjm 4947 38 may may MD cord-023095-4dannjjm 4947 39 be be VB cord-023095-4dannjjm 4947 40 exacerbated exacerbate VBN cord-023095-4dannjjm 4947 41 by by IN cord-023095-4dannjjm 4947 42 eicosanoids eicosanoid NNS cord-023095-4dannjjm 4947 43 derived derive VBN cord-023095-4dannjjm 4947 44 from from IN cord-023095-4dannjjm 4947 45 ( ( -LRB- cord-023095-4dannjjm 4947 46 n-6 n-6 NN cord-023095-4dannjjm 4947 47 ) ) -RRB- cord-023095-4dannjjm 4947 48 arachidonic arachidonic NN cord-023095-4dannjjm 4947 49 acid acid NN cord-023095-4dannjjm 4947 50 ( ( -LRB- cord-023095-4dannjjm 4947 51 AA AA NNP cord-023095-4dannjjm 4947 52 ) ) -RRB- cord-023095-4dannjjm 4947 53 . . . cord-023095-4dannjjm 4948 1 This this DT cord-023095-4dannjjm 4948 2 study study NN cord-023095-4dannjjm 4948 3 investigated investigate VBD cord-023095-4dannjjm 4948 4 the the DT cord-023095-4dannjjm 4948 5 effects effect NNS cord-023095-4dannjjm 4948 6 of of IN cord-023095-4dannjjm 4948 7 adding add VBG cord-023095-4dannjjm 4948 8 MCT MCT NNP cord-023095-4dannjjm 4948 9 : : : cord-023095-4dannjjm 4948 10 FO FO NNP cord-023095-4dannjjm 4948 11 and and CC cord-023095-4dannjjm 4948 12 L l NN cord-023095-4dannjjm 4948 13 - - HYPH cord-023095-4dannjjm 4948 14 carnitine carnitine NN cord-023095-4dannjjm 4948 15 to to IN cord-023095-4dannjjm 4948 16 a a DT cord-023095-4dannjjm 4948 17 control control NN cord-023095-4dannjjm 4948 18 diet diet NN cord-023095-4dannjjm 4948 19 ( ( -LRB- cord-023095-4dannjjm 4948 20 Prescription Prescription NNP cord-023095-4dannjjm 4948 21 Diet Diet NNP cord-023095-4dannjjm 4948 22 s s POS cord-023095-4dannjjm 4948 23 k k NNP cord-023095-4dannjjm 4948 24 / / SYM cord-023095-4dannjjm 4948 25 d d NNP cord-023095-4dannjjm 4948 26 s s NNP cord-023095-4dannjjm 4948 27 ) ) -RRB- cord-023095-4dannjjm 4948 28 on on IN cord-023095-4dannjjm 4948 29 lean lean JJ cord-023095-4dannjjm 4948 30 body body NN cord-023095-4dannjjm 4948 31 mass mass NN cord-023095-4dannjjm 4948 32 , , , cord-023095-4dannjjm 4948 33 and and CC cord-023095-4dannjjm 4948 34 serum serum NN cord-023095-4dannjjm 4948 35 FA fa NN cord-023095-4dannjjm 4948 36 and and CC cord-023095-4dannjjm 4948 37 metabolites metabolite NNS cord-023095-4dannjjm 4948 38 . . . cord-023095-4dannjjm 4949 1 Forty forty CD cord-023095-4dannjjm 4949 2 healthy healthy JJ cord-023095-4dannjjm 4949 3 Beagles Beagles NNPS cord-023095-4dannjjm 4949 4 ( ( -LRB- cord-023095-4dannjjm 4949 5 3.1 3.1 CD cord-023095-4dannjjm 4949 6 to to IN cord-023095-4dannjjm 4949 7 14.8 14.8 CD cord-023095-4dannjjm 4949 8 y y NNP cord-023095-4dannjjm 4949 9 ) ) -RRB- cord-023095-4dannjjm 4949 10 were be VBD cord-023095-4dannjjm 4949 11 fed feed VBN cord-023095-4dannjjm 4949 12 one one CD cord-023095-4dannjjm 4949 13 of of IN cord-023095-4dannjjm 4949 14 three three CD cord-023095-4dannjjm 4949 15 foods food NNS cord-023095-4dannjjm 4949 16 ( ( -LRB- cord-023095-4dannjjm 4949 17 n n NN cord-023095-4dannjjm 4949 18 5 5 CD cord-023095-4dannjjm 4949 19 13 13 CD cord-023095-4dannjjm 4949 20 to to TO cord-023095-4dannjjm 4949 21 14 14 CD cord-023095-4dannjjm 4949 22 dogs dog NNS cord-023095-4dannjjm 4949 23 each each DT cord-023095-4dannjjm 4949 24 ) ) -RRB- cord-023095-4dannjjm 4949 25 for for IN cord-023095-4dannjjm 4949 26 6 6 CD cord-023095-4dannjjm 4949 27 mo mo NN cord-023095-4dannjjm 4949 28 . . . cord-023095-4dannjjm 4950 1 The the DT cord-023095-4dannjjm 4950 2 study study NN cord-023095-4dannjjm 4950 3 protocol protocol NN cord-023095-4dannjjm 4950 4 was be VBD cord-023095-4dannjjm 4950 5 reviewed review VBN cord-023095-4dannjjm 4950 6 and and CC cord-023095-4dannjjm 4950 7 approved approve VBN cord-023095-4dannjjm 4950 8 by by IN cord-023095-4dannjjm 4950 9 IACUC IACUC NNP cord-023095-4dannjjm 4950 10 , , , cord-023095-4dannjjm 4950 11 Hill Hill NNP cord-023095-4dannjjm 4950 12 's 's POS cord-023095-4dannjjm 4950 13 Pet Pet NNP cord-023095-4dannjjm 4950 14 Nutrition Nutrition NNP cord-023095-4dannjjm 4950 15 , , , cord-023095-4dannjjm 4951 1 Inc. Inc. NNP cord-023095-4dannjjm 4951 2 All all DT cord-023095-4dannjjm 4951 3 foods food NNS cord-023095-4dannjjm 4951 4 were be VBD cord-023095-4dannjjm 4951 5 complete complete JJ cord-023095-4dannjjm 4951 6 , , , cord-023095-4dannjjm 4951 7 balanced balanced JJ cord-023095-4dannjjm 4951 8 , , , cord-023095-4dannjjm 4951 9 and and CC cord-023095-4dannjjm 4951 10 sufficient sufficient JJ cord-023095-4dannjjm 4951 11 for for IN cord-023095-4dannjjm 4951 12 maintenance maintenance NN cord-023095-4dannjjm 4951 13 of of IN cord-023095-4dannjjm 4951 14 adult adult NN cord-023095-4dannjjm 4951 15 dogs dog NNS cord-023095-4dannjjm 4951 16 ; ; : cord-023095-4dannjjm 4951 17 and and CC cord-023095-4dannjjm 4951 18 had have VBD cord-023095-4dannjjm 4951 19 similar similar JJ cord-023095-4dannjjm 4951 20 concentrations concentration NNS cord-023095-4dannjjm 4951 21 of of IN cord-023095-4dannjjm 4951 22 moisture moisture NN cord-023095-4dannjjm 4951 23 , , , cord-023095-4dannjjm 4951 24 protein protein NN cord-023095-4dannjjm 4951 25 , , , cord-023095-4dannjjm 4951 26 and and CC cord-023095-4dannjjm 4951 27 fat fat JJ cord-023095-4dannjjm 4951 28 ( ( -LRB- cord-023095-4dannjjm 4951 29 approx approx NN cord-023095-4dannjjm 4951 30 . . . cord-023095-4dannjjm 4951 31 7.4 7.4 CD cord-023095-4dannjjm 4951 32 % % NN cord-023095-4dannjjm 4951 33 , , , cord-023095-4dannjjm 4951 34 14.0 14.0 CD cord-023095-4dannjjm 4951 35 % % NN cord-023095-4dannjjm 4951 36 , , , cord-023095-4dannjjm 4951 37 18.1 18.1 CD cord-023095-4dannjjm 4951 38 % % NN cord-023095-4dannjjm 4951 39 , , , cord-023095-4dannjjm 4951 40 respectively respectively RB cord-023095-4dannjjm 4951 41 ) ) -RRB- cord-023095-4dannjjm 4951 42 . . . cord-023095-4dannjjm 4952 1 Composition composition NN cord-023095-4dannjjm 4952 2 of of IN cord-023095-4dannjjm 4952 3 serum serum NN cord-023095-4dannjjm 4952 4 FA FA NNP cord-023095-4dannjjm 4952 5 was be VBD cord-023095-4dannjjm 4952 6 determined determine VBN cord-023095-4dannjjm 4952 7 by by IN cord-023095-4dannjjm 4952 8 gas gas NN cord-023095-4dannjjm 4952 9 chromatography chromatography NN cord-023095-4dannjjm 4952 10 of of IN cord-023095-4dannjjm 4952 11 FA FA NNP cord-023095-4dannjjm 4952 12 methyl methyl NN cord-023095-4dannjjm 4952 13 esters ester NNS cord-023095-4dannjjm 4952 14 . . . cord-023095-4dannjjm 4953 1 Metabolomic metabolomic JJ cord-023095-4dannjjm 4953 2 profiles profile NNS cord-023095-4dannjjm 4953 3 of of IN cord-023095-4dannjjm 4953 4 serum serum NN cord-023095-4dannjjm 4953 5 samples sample NNS cord-023095-4dannjjm 4953 6 were be VBD cord-023095-4dannjjm 4953 7 determined determine VBN cord-023095-4dannjjm 4953 8 from from IN cord-023095-4dannjjm 4953 9 extracted extract VBN cord-023095-4dannjjm 4953 10 supernatants supernatant NNS cord-023095-4dannjjm 4953 11 that that WDT cord-023095-4dannjjm 4953 12 were be VBD cord-023095-4dannjjm 4953 13 split split VBN cord-023095-4dannjjm 4953 14 and and CC cord-023095-4dannjjm 4953 15 run run VB cord-023095-4dannjjm 4953 16 on on IN cord-023095-4dannjjm 4953 17 GC GC NNP cord-023095-4dannjjm 4953 18 / / SYM cord-023095-4dannjjm 4953 19 MS MS NNP cord-023095-4dannjjm 4953 20 and and CC cord-023095-4dannjjm 4953 21 LC/ LC/ NNP cord-023095-4dannjjm 4953 22 MS MS NNP cord-023095-4dannjjm 4953 23 / / SYM cord-023095-4dannjjm 4953 24 MS MS NNP cord-023095-4dannjjm 4953 25 platforms platform NNS cord-023095-4dannjjm 4953 26 , , , cord-023095-4dannjjm 4953 27 for for IN cord-023095-4dannjjm 4953 28 identification identification NN cord-023095-4dannjjm 4953 29 and and CC cord-023095-4dannjjm 4953 30 relative relative JJ cord-023095-4dannjjm 4953 31 quantification quantification NN cord-023095-4dannjjm 4953 32 of of IN cord-023095-4dannjjm 4953 33 small small JJ cord-023095-4dannjjm 4953 34 metabolites metabolite NNS cord-023095-4dannjjm 4953 35 . . . cord-023095-4dannjjm 4954 1 Body body NN cord-023095-4dannjjm 4954 2 composition composition NN cord-023095-4dannjjm 4954 3 was be VBD cord-023095-4dannjjm 4954 4 determined determine VBN cord-023095-4dannjjm 4954 5 by by IN cord-023095-4dannjjm 4954 6 dual dual JJ cord-023095-4dannjjm 4954 7 energy energy NN cord-023095-4dannjjm 4954 8 x x NN cord-023095-4dannjjm 4954 9 - - NN cord-023095-4dannjjm 4954 10 ray ray NNP cord-023095-4dannjjm 4954 11 absorptiometry absorptiometry NN cord-023095-4dannjjm 4954 12 . . . cord-023095-4dannjjm 4955 1 Serum serum NN cord-023095-4dannjjm 4955 2 concentrations concentration NNS cord-023095-4dannjjm 4955 3 of of IN cord-023095-4dannjjm 4955 4 lauric lauric JJ cord-023095-4dannjjm 4955 5 and and CC cord-023095-4dannjjm 4955 6 myristic myristic JJ cord-023095-4dannjjm 4955 7 FA FA NNP cord-023095-4dannjjm 4955 8 increased increase VBD cord-023095-4dannjjm 4955 9 ; ; : cord-023095-4dannjjm 4955 10 EPA EPA NNP cord-023095-4dannjjm 4955 11 and and CC cord-023095-4dannjjm 4955 12 DHA DHA NNP cord-023095-4dannjjm 4955 13 increased increase VBD cord-023095-4dannjjm 4955 14 in in IN cord-023095-4dannjjm 4955 15 a a DT cord-023095-4dannjjm 4955 16 dose dose NN cord-023095-4dannjjm 4955 17 - - HYPH cord-023095-4dannjjm 4955 18 dependent dependent JJ cord-023095-4dannjjm 4955 19 manner manner NN cord-023095-4dannjjm 4955 20 ; ; : cord-023095-4dannjjm 4955 21 and and CC cord-023095-4dannjjm 4955 22 AA AA NNP cord-023095-4dannjjm 4955 23 decreased decrease VBD cord-023095-4dannjjm 4955 24 in in IN cord-023095-4dannjjm 4955 25 dogs dog NNS cord-023095-4dannjjm 4955 26 fed fed NNP cord-023095-4dannjjm 4955 27 treatment treatment NN cord-023095-4dannjjm 4955 28 food food NN cord-023095-4dannjjm 4955 29 3 3 CD cord-023095-4dannjjm 4955 30 ( ( -LRB- cord-023095-4dannjjm 4955 31 proc proc VB cord-023095-4dannjjm 4955 32 - - HYPH cord-023095-4dannjjm 4955 33 mixed mix VBN cord-023095-4dannjjm 4955 34 procedure procedure NN cord-023095-4dannjjm 4955 35 in in IN cord-023095-4dannjjm 4955 36 SAS SAS NNP cord-023095-4dannjjm 4955 37 ; ; : cord-023095-4dannjjm 4955 38 all all DT cord-023095-4dannjjm 4955 39 P p NN cord-023095-4dannjjm 4955 40 0.05 0.05 CD cord-023095-4dannjjm 4955 41 ) ) -RRB- cord-023095-4dannjjm 4955 42 when when WRB cord-023095-4dannjjm 4955 43 compared compare VBN cord-023095-4dannjjm 4955 44 to to IN cord-023095-4dannjjm 4955 45 dogs dog NNS cord-023095-4dannjjm 4955 46 fed fed NNP cord-023095-4dannjjm 4955 47 treatment treatment NN cord-023095-4dannjjm 4955 48 foods food NNS cord-023095-4dannjjm 4955 49 1 1 CD cord-023095-4dannjjm 4955 50 or or CC cord-023095-4dannjjm 4955 51 2 2 CD cord-023095-4dannjjm 4955 52 . . . cord-023095-4dannjjm 4956 1 Serum serum NN cord-023095-4dannjjm 4956 2 concentrations concentration NNS cord-023095-4dannjjm 4956 3 of of IN cord-023095-4dannjjm 4956 4 acetylcarnitine acetylcarnitine NNP cord-023095-4dannjjm 4956 5 and and CC cord-023095-4dannjjm 4956 6 succinylcarnitine succinylcarnitine NNP cord-023095-4dannjjm 4956 7 increased increase VBD cord-023095-4dannjjm 4956 8 , , , cord-023095-4dannjjm 4956 9 indicating indicate VBG cord-023095-4dannjjm 4956 10 Lcarnitine Lcarnitine NNP cord-023095-4dannjjm 4956 11 incorporation incorporation NN cord-023095-4dannjjm 4956 12 , , , cord-023095-4dannjjm 4956 13 in in IN cord-023095-4dannjjm 4956 14 dogs dog NNS cord-023095-4dannjjm 4956 15 fed feed VBD cord-023095-4dannjjm 4956 16 treatment treatment NN cord-023095-4dannjjm 4956 17 foods food NNS cord-023095-4dannjjm 4956 18 2 2 CD cord-023095-4dannjjm 4956 19 and and CC cord-023095-4dannjjm 4956 20 3 3 CD cord-023095-4dannjjm 4956 21 . . . cord-023095-4dannjjm 4957 1 Thus thus RB cord-023095-4dannjjm 4957 2 , , , cord-023095-4dannjjm 4957 3 a a DT cord-023095-4dannjjm 4957 4 diet diet NN cord-023095-4dannjjm 4957 5 enriched enrich VBN cord-023095-4dannjjm 4957 6 with with IN cord-023095-4dannjjm 4957 7 MCT MCT NNP cord-023095-4dannjjm 4957 8 : : : cord-023095-4dannjjm 4957 9 FO FO NNP cord-023095-4dannjjm 4957 10 significantly significantly RB cord-023095-4dannjjm 4957 11 altered alter VBD cord-023095-4dannjjm 4957 12 serum serum NN cord-023095-4dannjjm 4957 13 FA fa NN cord-023095-4dannjjm 4957 14 composition composition NN cord-023095-4dannjjm 4957 15 , , , cord-023095-4dannjjm 4957 16 enriching enrich VBG cord-023095-4dannjjm 4957 17 ( ( -LRB- cord-023095-4dannjjm 4957 18 n-3 n-3 NN cord-023095-4dannjjm 4957 19 ) ) -RRB- cord-023095-4dannjjm 4957 20 PUFA PUFA NNP cord-023095-4dannjjm 4957 21 and and CC cord-023095-4dannjjm 4957 22 lowering lower VBG cord-023095-4dannjjm 4957 23 AA AA NNP cord-023095-4dannjjm 4957 24 concentrations concentration NNS cord-023095-4dannjjm 4957 25 . . . cord-023095-4dannjjm 4958 1 There there EX cord-023095-4dannjjm 4958 2 was be VBD cord-023095-4dannjjm 4958 3 no no DT cord-023095-4dannjjm 4958 4 change change NN cord-023095-4dannjjm 4958 5 in in IN cord-023095-4dannjjm 4958 6 lean lean JJ cord-023095-4dannjjm 4958 7 body body NN cord-023095-4dannjjm 4958 8 mass mass NN cord-023095-4dannjjm 4958 9 for for IN cord-023095-4dannjjm 4958 10 any any DT cord-023095-4dannjjm 4958 11 of of IN cord-023095-4dannjjm 4958 12 the the DT cord-023095-4dannjjm 4958 13 diets diet NNS cord-023095-4dannjjm 4958 14 compared compare VBN cord-023095-4dannjjm 4958 15 to to IN cord-023095-4dannjjm 4958 16 baseline baseline JJ cord-023095-4dannjjm 4958 17 values value NNS cord-023095-4dannjjm 4958 18 , , , cord-023095-4dannjjm 4958 19 and and CC cord-023095-4dannjjm 4958 20 no no DT cord-023095-4dannjjm 4958 21 difference difference NN cord-023095-4dannjjm 4958 22 between between IN cord-023095-4dannjjm 4958 23 treatments treatment NNS cord-023095-4dannjjm 4958 24 , , , cord-023095-4dannjjm 4958 25 showing show VBG cord-023095-4dannjjm 4958 26 that that IN cord-023095-4dannjjm 4958 27 all all DT cord-023095-4dannjjm 4958 28 three three CD cord-023095-4dannjjm 4958 29 treatment treatment NN cord-023095-4dannjjm 4958 30 foods food NNS cord-023095-4dannjjm 4958 31 met meet VBD cord-023095-4dannjjm 4958 32 protein protein NN cord-023095-4dannjjm 4958 33 requirements requirement NNS cord-023095-4dannjjm 4958 34 . . . cord-023095-4dannjjm 4959 1 Ten ten CD cord-023095-4dannjjm 4959 2 owned own VBN cord-023095-4dannjjm 4959 3 dogs dog NNS cord-023095-4dannjjm 4959 4 , , , cord-023095-4dannjjm 4959 5 obese obese JJ cord-023095-4dannjjm 4959 6 for for IN cord-023095-4dannjjm 4959 7 more more JJR cord-023095-4dannjjm 4959 8 than than IN cord-023095-4dannjjm 4959 9 12 12 CD cord-023095-4dannjjm 4959 10 months month NNS cord-023095-4dannjjm 4959 11 ( ( -LRB- cord-023095-4dannjjm 4959 12 body body NN cord-023095-4dannjjm 4959 13 condition condition NN cord-023095-4dannjjm 4959 14 score score NN cord-023095-4dannjjm 4959 15 [ [ -LRB- cord-023095-4dannjjm 4959 16 BCS BCS NNP cord-023095-4dannjjm 4959 17 ] ] -RRB- cord-023095-4dannjjm 4959 18 of of IN cord-023095-4dannjjm 4959 19 9 9 CD cord-023095-4dannjjm 4959 20 ; ; : cord-023095-4dannjjm 4959 21 fat fat JJ cord-023095-4dannjjm 4959 22 mass mass NN cord-023095-4dannjjm 4959 23 [ [ -LRB- cord-023095-4dannjjm 4959 24 FM FM NNP cord-023095-4dannjjm 4959 25 ] ] -RRB- cord-023095-4dannjjm 4959 26 5 5 CD cord-023095-4dannjjm 4959 27 45.7 45.7 CD cord-023095-4dannjjm 4959 28 AE AE NNP cord-023095-4dannjjm 4959 29 1.51 1.51 CD cord-023095-4dannjjm 4959 30 % % NN cord-023095-4dannjjm 4959 31 ) ) -RRB- cord-023095-4dannjjm 4959 32 were be VBD cord-023095-4dannjjm 4959 33 studied study VBN cord-023095-4dannjjm 4959 34 . . . cord-023095-4dannjjm 4960 1 These these DT cord-023095-4dannjjm 4960 2 dogs dog NNS cord-023095-4dannjjm 4960 3 had have VBD cord-023095-4dannjjm 4960 4 their -PRON- PRP$ cord-023095-4dannjjm 4960 5 weight weight NN cord-023095-4dannjjm 4960 6 reduced reduce VBN cord-023095-4dannjjm 4960 7 by by IN cord-023095-4dannjjm 4960 8 20 20 CD cord-023095-4dannjjm 4960 9 % % NN cord-023095-4dannjjm 4960 10 ( ( -LRB- cord-023095-4dannjjm 4960 11 BCS BCS NNP cord-023095-4dannjjm 4960 12 5 5 CD cord-023095-4dannjjm 4960 13 8 8 CD cord-023095-4dannjjm 4960 14 ; ; : cord-023095-4dannjjm 4960 15 FM FM NNP cord-023095-4dannjjm 4960 16 5 5 CD cord-023095-4dannjjm 4960 17 33.5 33.5 CD cord-023095-4dannjjm 4960 18 AE AE NNP cord-023095-4dannjjm 4960 19 1.92 1.92 CD cord-023095-4dannjjm 4960 20 % % NN cord-023095-4dannjjm 4960 21 ; ; : cord-023095-4dannjjm 4960 22 P p NN cord-023095-4dannjjm 4960 23 o o NN cord-023095-4dannjjm 4960 24 0.001 0.001 CD cord-023095-4dannjjm 4960 25 ) ) -RRB- cord-023095-4dannjjm 4960 26 being be VBG cord-023095-4dannjjm 4960 27 designated designate VBN cord-023095-4dannjjm 4960 28 weight weight NN cord-023095-4dannjjm 4960 29 reduced reduce VBN cord-023095-4dannjjm 4960 30 ( ( -LRB- cord-023095-4dannjjm 4960 31 WR WR NNP cord-023095-4dannjjm 4960 32 ) ) -RRB- cord-023095-4dannjjm 4960 33 group group NN cord-023095-4dannjjm 4961 1 and and CC cord-023095-4dannjjm 4961 2 then then RB cord-023095-4dannjjm 4961 3 were be VBD cord-023095-4dannjjm 4961 4 fed feed VBN cord-023095-4dannjjm 4961 5 to to TO cord-023095-4dannjjm 4961 6 maintain maintain VB cord-023095-4dannjjm 4961 7 constant constant JJ cord-023095-4dannjjm 4961 8 body body NN cord-023095-4dannjjm 4961 9 weight weight NN cord-023095-4dannjjm 4961 10 during during IN cord-023095-4dannjjm 4961 11 150 150 CD cord-023095-4dannjjm 4961 12 days day NNS cord-023095-4dannjjm 4962 1 ( ( -LRB- cord-023095-4dannjjm 4962 2 BCS BCS NNP cord-023095-4dannjjm 4962 3 5 5 CD cord-023095-4dannjjm 4962 4 8.2 8.2 CD cord-023095-4dannjjm 4962 5 ; ; : cord-023095-4dannjjm 4962 6 P p NN cord-023095-4dannjjm 4962 7 5 5 CD cord-023095-4dannjjm 4962 8 0.6 0.6 CD cord-023095-4dannjjm 4962 9 ) ) -RRB- cord-023095-4dannjjm 4962 10 , , , cord-023095-4dannjjm 4962 11 designated designated JJ cord-023095-4dannjjm 4962 12 maintenance maintenance NN cord-023095-4dannjjm 4962 13 ( ( -LRB- cord-023095-4dannjjm 4962 14 MAIN MAIN NNP cord-023095-4dannjjm 4962 15 ) ) -RRB- cord-023095-4dannjjm 4962 16 group group NN cord-023095-4dannjjm 4962 17 . . . cord-023095-4dannjjm 4963 1 A a DT cord-023095-4dannjjm 4963 2 control control NN cord-023095-4dannjjm 4963 3 ( ( -LRB- cord-023095-4dannjjm 4963 4 CT CT NNP cord-023095-4dannjjm 4963 5 ) ) -RRB- cord-023095-4dannjjm 4963 6 group group NN cord-023095-4dannjjm 4963 7 of of IN cord-023095-4dannjjm 4963 8 10 10 CD cord-023095-4dannjjm 4963 9 beagles beagle NNS cord-023095-4dannjjm 4963 10 was be VBD cord-023095-4dannjjm 4963 11 also also RB cord-023095-4dannjjm 4963 12 included include VBN cord-023095-4dannjjm 4963 13 ( ( -LRB- cord-023095-4dannjjm 4963 14 BCS BCS NNP cord-023095-4dannjjm 4963 15 5 5 CD cord-023095-4dannjjm 4963 16 4.5 4.5 CD cord-023095-4dannjjm 4963 17 ; ; : cord-023095-4dannjjm 4963 18 FM FM NNP cord-023095-4dannjjm 4963 19 5 5 CD cord-023095-4dannjjm 4963 20 18.3 18.3 CD cord-023095-4dannjjm 4963 21 AE AE NNP cord-023095-4dannjjm 4963 22 1.38 1.38 CD cord-023095-4dannjjm 4963 23 % % NN cord-023095-4dannjjm 4963 24 ; ; : cord-023095-4dannjjm 4963 25 P p NN cord-023095-4dannjjm 4963 26 o o NN cord-023095-4dannjjm 4963 27 0.01 0.01 CD cord-023095-4dannjjm 4963 28 ) ) -RRB- cord-023095-4dannjjm 4963 29 . . . cord-023095-4dannjjm 4964 1 In in IN cord-023095-4dannjjm 4964 2 all all DT cord-023095-4dannjjm 4964 3 groups group NNS cord-023095-4dannjjm 4964 4 the the DT cord-023095-4dannjjm 4964 5 glucose glucose NN cord-023095-4dannjjm 4964 6 postprandial postprandial JJ cord-023095-4dannjjm 4964 7 response response NN cord-023095-4dannjjm 4964 8 test test NN cord-023095-4dannjjm 4964 9 was be VBD cord-023095-4dannjjm 4964 10 performed perform VBN cord-023095-4dannjjm 4964 11 after after IN cord-023095-4dannjjm 4964 12 12 12 CD cord-023095-4dannjjm 4964 13 hours hour NNS cord-023095-4dannjjm 4964 14 of of IN cord-023095-4dannjjm 4964 15 fasting fast VBG cord-023095-4dannjjm 4964 16 . . . cord-023095-4dannjjm 4965 1 Blood blood NN cord-023095-4dannjjm 4965 2 samples sample NNS cord-023095-4dannjjm 4965 3 were be VBD cord-023095-4dannjjm 4965 4 taken take VBN cord-023095-4dannjjm 4965 5 prefeeding prefeede VBG cord-023095-4dannjjm 4965 6 and and CC cord-023095-4dannjjm 4965 7 after after IN cord-023095-4dannjjm 4965 8 5 5 CD cord-023095-4dannjjm 4965 9 , , , cord-023095-4dannjjm 4965 10 10 10 CD cord-023095-4dannjjm 4965 11 , , , cord-023095-4dannjjm 4965 12 15 15 CD cord-023095-4dannjjm 4965 13 , , , cord-023095-4dannjjm 4965 14 30 30 CD cord-023095-4dannjjm 4965 15 , , , cord-023095-4dannjjm 4965 16 45 45 CD cord-023095-4dannjjm 4965 17 , , , cord-023095-4dannjjm 4965 18 60 60 CD cord-023095-4dannjjm 4965 19 , , , cord-023095-4dannjjm 4965 20 120 120 CD cord-023095-4dannjjm 4965 21 , , , cord-023095-4dannjjm 4965 22 180 180 CD cord-023095-4dannjjm 4965 23 , , , cord-023095-4dannjjm 4965 24 240 240 CD cord-023095-4dannjjm 4965 25 , , , cord-023095-4dannjjm 4965 26 300 300 CD cord-023095-4dannjjm 4965 27 and and CC cord-023095-4dannjjm 4965 28 360 360 CD cord-023095-4dannjjm 4965 29 minutes minute NNS cord-023095-4dannjjm 4965 30 of of IN cord-023095-4dannjjm 4965 31 the the DT cord-023095-4dannjjm 4965 32 consumption consumption NN cord-023095-4dannjjm 4965 33 of of IN cord-023095-4dannjjm 4965 34 cooked cook VBN cord-023095-4dannjjm 4965 35 rice rice NN cord-023095-4dannjjm 4965 36 enough enough RB cord-023095-4dannjjm 4965 37 to to IN cord-023095-4dannjjm 4965 38 the the DT cord-023095-4dannjjm 4965 39 ingestion ingestion NN cord-023095-4dannjjm 4965 40 of of IN cord-023095-4dannjjm 4965 41 6 6 CD cord-023095-4dannjjm 4965 42 g g NN cord-023095-4dannjjm 4965 43 of of IN cord-023095-4dannjjm 4965 44 starch starch NN cord-023095-4dannjjm 4965 45 / / SYM cord-023095-4dannjjm 4965 46 kg kg NN cord-023095-4dannjjm 4965 47 body body NN cord-023095-4dannjjm 4965 48 weight weight NN cord-023095-4dannjjm 4965 49 . . . cord-023095-4dannjjm 4966 1 TNF TNF NNP cord-023095-4dannjjm 4966 2 - - : cord-023095-4dannjjm 4966 3 a a DT cord-023095-4dannjjm 4967 1 and and CC cord-023095-4dannjjm 4967 2 IL-6 IL-6 NNP cord-023095-4dannjjm 4967 3 were be VBD cord-023095-4dannjjm 4967 4 dosed dose VBN cord-023095-4dannjjm 4967 5 in in IN cord-023095-4dannjjm 4967 6 MILLIPLEX MILLIPLEX NNP cord-023095-4dannjjm 4967 7 TM TM NNP cord-023095-4dannjjm 4967 8 MAP MAP NNP cord-023095-4dannjjm 4967 9 panel panel NN cord-023095-4dannjjm 4967 10 , , , cord-023095-4dannjjm 4967 11 insulin insulin NN cord-023095-4dannjjm 4967 12 and and CC cord-023095-4dannjjm 4967 13 leptin leptin NN cord-023095-4dannjjm 4967 14 by by IN cord-023095-4dannjjm 4967 15 radioimmunoassay radioimmunoassay JJ cord-023095-4dannjjm 4967 16 . . . cord-023095-4dannjjm 4968 1 Statistical statistical JJ cord-023095-4dannjjm 4968 2 analysis analysis NN cord-023095-4dannjjm 4968 3 included include VBD cord-023095-4dannjjm 4968 4 paired pair VBN cord-023095-4dannjjm 4968 5 or or CC cord-023095-4dannjjm 4968 6 non non JJ cord-023095-4dannjjm 4968 7 - - JJ cord-023095-4dannjjm 4968 8 paired paired JJ cord-023095-4dannjjm 4968 9 T t NN cord-023095-4dannjjm 4968 10 - - HYPH cord-023095-4dannjjm 4968 11 tests test NNS cord-023095-4dannjjm 4968 12 and and CC cord-023095-4dannjjm 4968 13 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 4968 14 ( ( -LRB- cord-023095-4dannjjm 4968 15 P p NN cord-023095-4dannjjm 4968 16 o o NN cord-023095-4dannjjm 4968 17 0.05 0.05 CD cord-023095-4dannjjm 4968 18 ) ) -RRB- cord-023095-4dannjjm 4968 19 . . . cord-023095-4dannjjm 4969 1 The the DT cord-023095-4dannjjm 4969 2 regimen regimen NN cord-023095-4dannjjm 4969 3 normalized normalize VBD cord-023095-4dannjjm 4969 4 meal meal NN cord-023095-4dannjjm 4969 5 glucose glucose NN cord-023095-4dannjjm 4969 6 response response NN cord-023095-4dannjjm 4969 7 , , , cord-023095-4dannjjm 4969 8 the the DT cord-023095-4dannjjm 4969 9 area area NN cord-023095-4dannjjm 4969 10 under under IN cord-023095-4dannjjm 4969 11 the the DT cord-023095-4dannjjm 4969 12 curve curve NN cord-023095-4dannjjm 4969 13 ( ( -LRB- cord-023095-4dannjjm 4969 14 AUC AUC NNP cord-023095-4dannjjm 4969 15 ) ) -RRB- cord-023095-4dannjjm 4969 16 of of IN cord-023095-4dannjjm 4969 17 glucose glucose NN cord-023095-4dannjjm 4969 18 for for IN cord-023095-4dannjjm 4969 19 WR WR NNP cord-023095-4dannjjm 4969 20 was be VBD cord-023095-4dannjjm 4969 21 lower low JJR cord-023095-4dannjjm 4969 22 than than IN cord-023095-4dannjjm 4969 23 for for IN cord-023095-4dannjjm 4969 24 obese obese JJ cord-023095-4dannjjm 4969 25 ( ( -LRB- cord-023095-4dannjjm 4969 26 P p NN cord-023095-4dannjjm 4969 27 o o NN cord-023095-4dannjjm 4969 28 0.05 0.05 CD cord-023095-4dannjjm 4969 29 ) ) -RRB- cord-023095-4dannjjm 4969 30 and and CC cord-023095-4dannjjm 4969 31 similar similar JJ cord-023095-4dannjjm 4969 32 to to IN cord-023095-4dannjjm 4969 33 MAIN MAIN NNP cord-023095-4dannjjm 4969 34 and and CC cord-023095-4dannjjm 4969 35 CT CT NNP cord-023095-4dannjjm 4969 36 ( ( -LRB- cord-023095-4dannjjm 4969 37 P p NN cord-023095-4dannjjm 4969 38 4 4 CD cord-023095-4dannjjm 4969 39 0.05 0.05 CD cord-023095-4dannjjm 4969 40 ) ) -RRB- cord-023095-4dannjjm 4969 41 . . . cord-023095-4dannjjm 4970 1 Insulin insulin NN cord-023095-4dannjjm 4970 2 secretion secretion NN cord-023095-4dannjjm 4970 3 did do VBD cord-023095-4dannjjm 4970 4 not not RB cord-023095-4dannjjm 4970 5 normalize normalize VB cord-023095-4dannjjm 4970 6 immediately immediately RB cord-023095-4dannjjm 4970 7 , , , cord-023095-4dannjjm 4970 8 as as IN cord-023095-4dannjjm 4970 9 obese obese JJ cord-023095-4dannjjm 4970 10 and and CC cord-023095-4dannjjm 4970 11 WR WR NNP cord-023095-4dannjjm 4970 12 exhibited exhibit VBD cord-023095-4dannjjm 4970 13 similar similar JJ cord-023095-4dannjjm 4970 14 AUC auc NN cord-023095-4dannjjm 4970 15 of of IN cord-023095-4dannjjm 4970 16 insulin insulin NN cord-023095-4dannjjm 4970 17 and and CC cord-023095-4dannjjm 4970 18 higher high JJR cord-023095-4dannjjm 4970 19 values value NNS cord-023095-4dannjjm 4970 20 than than IN cord-023095-4dannjjm 4970 21 for for IN cord-023095-4dannjjm 4970 22 CT CT NNP cord-023095-4dannjjm 4970 23 ( ( -LRB- cord-023095-4dannjjm 4970 24 P p NN cord-023095-4dannjjm 4970 25 o o NN cord-023095-4dannjjm 4970 26 0.05 0.05 CD cord-023095-4dannjjm 4970 27 ) ) -RRB- cord-023095-4dannjjm 4970 28 . . . cord-023095-4dannjjm 4971 1 MAIN MAIN NNP cord-023095-4dannjjm 4971 2 , , , cord-023095-4dannjjm 4971 3 however however RB cord-023095-4dannjjm 4971 4 , , , cord-023095-4dannjjm 4971 5 presented present VBD cord-023095-4dannjjm 4971 6 similar similar JJ cord-023095-4dannjjm 4971 7 AUC auc NN cord-023095-4dannjjm 4971 8 of of IN cord-023095-4dannjjm 4971 9 insulin insulin NN cord-023095-4dannjjm 4971 10 than than IN cord-023095-4dannjjm 4971 11 CT CT NNP cord-023095-4dannjjm 4971 12 , , , cord-023095-4dannjjm 4971 13 with with IN cord-023095-4dannjjm 4971 14 lower low JJR cord-023095-4dannjjm 4971 15 values value NNS cord-023095-4dannjjm 4971 16 than than IN cord-023095-4dannjjm 4971 17 obese obese JJ cord-023095-4dannjjm 4971 18 and and CC cord-023095-4dannjjm 4971 19 WR WR NNP cord-023095-4dannjjm 4971 20 ( ( -LRB- cord-023095-4dannjjm 4971 21 P p NN cord-023095-4dannjjm 4971 22 o o NN cord-023095-4dannjjm 4971 23 0.01 0.01 CD cord-023095-4dannjjm 4971 24 ) ) -RRB- cord-023095-4dannjjm 4971 25 , , , cord-023095-4dannjjm 4971 26 suggesting suggest VBG cord-023095-4dannjjm 4971 27 that that IN cord-023095-4dannjjm 4971 28 dogs dog NNS cord-023095-4dannjjm 4971 29 require require VBP cord-023095-4dannjjm 4971 30 some some DT cord-023095-4dannjjm 4971 31 time time NN cord-023095-4dannjjm 4971 32 to to TO cord-023095-4dannjjm 4971 33 adapt adapt VB cord-023095-4dannjjm 4971 34 their -PRON- PRP$ cord-023095-4dannjjm 4971 35 metabolism metabolism NN cord-023095-4dannjjm 4971 36 . . . cord-023095-4dannjjm 4972 1 Leptin Leptin NNP cord-023095-4dannjjm 4972 2 , , , cord-023095-4dannjjm 4972 3 TNF TNF NNP cord-023095-4dannjjm 4972 4 - - HYPH cord-023095-4dannjjm 4972 5 a a NNP cord-023095-4dannjjm 4972 6 , , , cord-023095-4dannjjm 4972 7 and and CC cord-023095-4dannjjm 4972 8 IL-6 IL-6 NNP cord-023095-4dannjjm 4972 9 presented present VBD cord-023095-4dannjjm 4972 10 significant significant JJ cord-023095-4dannjjm 4972 11 reductions reduction NNS cord-023095-4dannjjm 4972 12 after after IN cord-023095-4dannjjm 4972 13 weight weight NN cord-023095-4dannjjm 4972 14 loss loss NN cord-023095-4dannjjm 4972 15 ( ( -LRB- cord-023095-4dannjjm 4972 16 P p NN cord-023095-4dannjjm 4972 17 o o NN cord-023095-4dannjjm 4972 18 0.05 0.05 CD cord-023095-4dannjjm 4972 19 ) ) -RRB- cord-023095-4dannjjm 4972 20 , , , cord-023095-4dannjjm 4972 21 without without IN cord-023095-4dannjjm 4972 22 differences difference NNS cord-023095-4dannjjm 4972 23 between between IN cord-023095-4dannjjm 4972 24 WR WR NNP cord-023095-4dannjjm 4972 25 , , , cord-023095-4dannjjm 4972 26 MAIN MAIN NNP cord-023095-4dannjjm 4972 27 and and CC cord-023095-4dannjjm 4972 28 CT CT NNP cord-023095-4dannjjm 4972 29 ( ( -LRB- cord-023095-4dannjjm 4972 30 P p NN cord-023095-4dannjjm 4972 31 4 4 CD cord-023095-4dannjjm 4972 32 0.05 0.05 CD cord-023095-4dannjjm 4972 33 ) ) -RRB- cord-023095-4dannjjm 4972 34 , , , cord-023095-4dannjjm 4972 35 suggesting suggest VBG cord-023095-4dannjjm 4972 36 an an DT cord-023095-4dannjjm 4972 37 improvement improvement NN cord-023095-4dannjjm 4972 38 of of IN cord-023095-4dannjjm 4972 39 the the DT cord-023095-4dannjjm 4972 40 pro pro JJ cord-023095-4dannjjm 4972 41 - - JJ cord-023095-4dannjjm 4972 42 inflammatory inflammatory JJ cord-023095-4dannjjm 4972 43 state state NN cord-023095-4dannjjm 4972 44 consequent consequent NN cord-023095-4dannjjm 4972 45 to to IN cord-023095-4dannjjm 4972 46 obesity obesity NN cord-023095-4dannjjm 4972 47 . . . cord-023095-4dannjjm 4973 1 Studying study VBG cord-023095-4dannjjm 4973 2 food food NN cord-023095-4dannjjm 4973 3 base base NN cord-023095-4dannjjm 4973 4 excess excess NN cord-023095-4dannjjm 4973 5 ( ( -LRB- cord-023095-4dannjjm 4973 6 BE be VB cord-023095-4dannjjm 4973 7 ) ) -RRB- cord-023095-4dannjjm 4973 8 modification modification NN cord-023095-4dannjjm 4973 9 , , , cord-023095-4dannjjm 4973 10 methionine methionine NN cord-023095-4dannjjm 4973 11 intoxication intoxication NN cord-023095-4dannjjm 4973 12 was be VBD cord-023095-4dannjjm 4973 13 described describe VBN cord-023095-4dannjjm 4973 14 . . . cord-023095-4dannjjm 4974 1 In in IN cord-023095-4dannjjm 4974 2 a a DT cord-023095-4dannjjm 4974 3 basal basal NN cord-023095-4dannjjm 4974 4 kibble kibble NN cord-023095-4dannjjm 4974 5 dog dog NN cord-023095-4dannjjm 4974 6 diet diet NN cord-023095-4dannjjm 4974 7 ( ( -LRB- cord-023095-4dannjjm 4974 8 BE be VB cord-023095-4dannjjm 4974 9 5 5 CD cord-023095-4dannjjm 4974 10 305 305 CD cord-023095-4dannjjm 4974 11 mEq mEq NNS cord-023095-4dannjjm 4974 12 / / SYM cord-023095-4dannjjm 4974 13 kg kg NNS cord-023095-4dannjjm 4974 14 ; ; : cord-023095-4dannjjm 4974 15 1.98 1.98 CD cord-023095-4dannjjm 4974 16 g g NN cord-023095-4dannjjm 4974 17 / / SYM cord-023095-4dannjjm 4974 18 kg kg NN cord-023095-4dannjjm 4974 19 of of IN cord-023095-4dannjjm 4974 20 S S NNP cord-023095-4dannjjm 4974 21 ) ) -RRB- cord-023095-4dannjjm 4975 1 two two CD cord-023095-4dannjjm 4975 2 dosages dosage NNS cord-023095-4dannjjm 4975 3 of of IN cord-023095-4dannjjm 4975 4 ammonium ammonium NN cord-023095-4dannjjm 4975 5 sulphate sulphate NN cord-023095-4dannjjm 4975 6 and and CC cord-023095-4dannjjm 4975 7 Methionine Methionine NNP cord-023095-4dannjjm 4975 8 was be VBD cord-023095-4dannjjm 4975 9 added add VBN cord-023095-4dannjjm 4975 10 , , , cord-023095-4dannjjm 4975 11 resulting result VBG cord-023095-4dannjjm 4975 12 in in IN cord-023095-4dannjjm 4975 13 diets diet NNS cord-023095-4dannjjm 4975 14 with with IN cord-023095-4dannjjm 4975 15 BE be NN cord-023095-4dannjjm 4975 16 of of IN cord-023095-4dannjjm 4975 17 135 135 CD cord-023095-4dannjjm 4975 18 mEq mEq NNS cord-023095-4dannjjm 4975 19 / / SYM cord-023095-4dannjjm 4975 20 kg kg NNP cord-023095-4dannjjm 4975 21 ( ( -LRB- cord-023095-4dannjjm 4975 22 4.26 4.26 CD cord-023095-4dannjjm 4975 23 g g NN cord-023095-4dannjjm 4975 24 / / SYM cord-023095-4dannjjm 4975 25 kg kg NN cord-023095-4dannjjm 4975 26 of of IN cord-023095-4dannjjm 4975 27 S S NNP cord-023095-4dannjjm 4975 28 ) ) -RRB- cord-023095-4dannjjm 4975 29 and and CC cord-023095-4dannjjm 4975 30 À51 À51 NNP cord-023095-4dannjjm 4975 31 mEq mEq NNS cord-023095-4dannjjm 4975 32 / / SYM cord-023095-4dannjjm 4975 33 kg kg NN cord-023095-4dannjjm 4975 34 ( ( -LRB- cord-023095-4dannjjm 4975 35 6.65 6.65 CD cord-023095-4dannjjm 4975 36 g g NN cord-023095-4dannjjm 4975 37 / / SYM cord-023095-4dannjjm 4975 38 kg kg NN cord-023095-4dannjjm 4975 39 of of IN cord-023095-4dannjjm 4975 40 S S NNP cord-023095-4dannjjm 4975 41 ) ) -RRB- cord-023095-4dannjjm 4975 42 , , , cord-023095-4dannjjm 4975 43 or or CC cord-023095-4dannjjm 4975 44 BE be VB cord-023095-4dannjjm 4975 45 of of IN cord-023095-4dannjjm 4975 46 142 142 CD cord-023095-4dannjjm 4975 47 mEq mEq NNS cord-023095-4dannjjm 4975 48 / / SYM cord-023095-4dannjjm 4975 49 kg kg NNP cord-023095-4dannjjm 4975 50 ( ( -LRB- cord-023095-4dannjjm 4975 51 4.68 4.68 CD cord-023095-4dannjjm 4975 52 g g NN cord-023095-4dannjjm 4975 53 / / SYM cord-023095-4dannjjm 4975 54 kg kg NN cord-023095-4dannjjm 4975 55 of of IN cord-023095-4dannjjm 4975 56 S S NNP cord-023095-4dannjjm 4975 57 ) ) -RRB- cord-023095-4dannjjm 4975 58 and and CC cord-023095-4dannjjm 4975 59 4 4 CD cord-023095-4dannjjm 4975 60 mEq mEq NNS cord-023095-4dannjjm 4975 61 / / SYM cord-023095-4dannjjm 4975 62 kg kg NNP cord-023095-4dannjjm 4975 63 ( ( -LRB- cord-023095-4dannjjm 4975 64 7.49 7.49 CD cord-023095-4dannjjm 4975 65 g g NN cord-023095-4dannjjm 4975 66 / / SYM cord-023095-4dannjjm 4975 67 kg kg NN cord-023095-4dannjjm 4975 68 of of IN cord-023095-4dannjjm 4975 69 S S NNP cord-023095-4dannjjm 4975 70 ) ) -RRB- cord-023095-4dannjjm 4975 71 , , , cord-023095-4dannjjm 4975 72 respectively respectively RB cord-023095-4dannjjm 4975 73 . . . cord-023095-4dannjjm 4976 1 A a DT cord-023095-4dannjjm 4976 2 2 2 CD cord-023095-4dannjjm 4976 3 Â â CD cord-023095-4dannjjm 4976 4 2 2 CD cord-023095-4dannjjm 4976 5 factorial factorial NN cord-023095-4dannjjm 4976 6 plus plus CC cord-023095-4dannjjm 4976 7 a a DT cord-023095-4dannjjm 4976 8 control control NN cord-023095-4dannjjm 4976 9 diet diet NN cord-023095-4dannjjm 4976 10 design design NN cord-023095-4dannjjm 4976 11 , , , cord-023095-4dannjjm 4976 12 resulting result VBG cord-023095-4dannjjm 4976 13 in in IN cord-023095-4dannjjm 4976 14 five five CD cord-023095-4dannjjm 4976 15 treatments treatment NNS cord-023095-4dannjjm 4976 16 , , , cord-023095-4dannjjm 4976 17 and and CC cord-023095-4dannjjm 4976 18 32 32 CD cord-023095-4dannjjm 4976 19 adult adult NN cord-023095-4dannjjm 4976 20 health health NN cord-023095-4dannjjm 4976 21 beagle beagle NN cord-023095-4dannjjm 4976 22 dogs dog NNS cord-023095-4dannjjm 4976 23 were be VBD cord-023095-4dannjjm 4976 24 used use VBN cord-023095-4dannjjm 4976 25 , , , cord-023095-4dannjjm 4976 26 in in IN cord-023095-4dannjjm 4976 27 a a DT cord-023095-4dannjjm 4976 28 completed complete VBN cord-023095-4dannjjm 4976 29 randomized randomized JJ cord-023095-4dannjjm 4976 30 design design NN cord-023095-4dannjjm 4976 31 with with IN cord-023095-4dannjjm 4976 32 six six CD cord-023095-4dannjjm 4976 33 dogs dog NNS cord-023095-4dannjjm 4976 34 per per IN cord-023095-4dannjjm 4976 35 diet diet NN cord-023095-4dannjjm 4976 36 . . . cord-023095-4dannjjm 4977 1 A a DT cord-023095-4dannjjm 4977 2 5-d 5-d CD cord-023095-4dannjjm 4977 3 adaptation adaptation NN cord-023095-4dannjjm 4977 4 phase phase NN cord-023095-4dannjjm 4977 5 followed follow VBD cord-023095-4dannjjm 4977 6 3-d 3-d CD cord-023095-4dannjjm 4977 7 of of IN cord-023095-4dannjjm 4977 8 total total JJ cord-023095-4dannjjm 4977 9 urine urine NN cord-023095-4dannjjm 4977 10 collection collection NN cord-023095-4dannjjm 4977 11 ( ( -LRB- cord-023095-4dannjjm 4977 12 in in IN cord-023095-4dannjjm 4977 13 bottles bottle NNS cord-023095-4dannjjm 4977 14 with with IN cord-023095-4dannjjm 4977 15 100 100 CD cord-023095-4dannjjm 4977 16 mg mg NNS cord-023095-4dannjjm 4977 17 of of IN cord-023095-4dannjjm 4977 18 thymol thymol NN cord-023095-4dannjjm 4977 19 ) ) -RRB- cord-023095-4dannjjm 4977 20 . . . cord-023095-4dannjjm 4978 1 Urine urine NN cord-023095-4dannjjm 4978 2 were be VBD cord-023095-4dannjjm 4978 3 pooled pool VBN cord-023095-4dannjjm 4978 4 by by IN cord-023095-4dannjjm 4978 5 dog dog NN cord-023095-4dannjjm 4978 6 and and CC cord-023095-4dannjjm 4978 7 analyzed analyze VBD cord-023095-4dannjjm 4978 8 for for IN cord-023095-4dannjjm 4978 9 density density NN cord-023095-4dannjjm 4978 10 , , , cord-023095-4dannjjm 4978 11 volume volume NN cord-023095-4dannjjm 4978 12 and and CC cord-023095-4dannjjm 4978 13 pH. ph. NN cord-023095-4dannjjm 4978 14 Food Food NNP cord-023095-4dannjjm 4978 15 macroelements macroelement NNS cord-023095-4dannjjm 4978 16 were be VBD cord-023095-4dannjjm 4978 17 determined determine VBN cord-023095-4dannjjm 4978 18 by by IN cord-023095-4dannjjm 4978 19 standards standard NNS cord-023095-4dannjjm 4978 20 methods method NNS cord-023095-4dannjjm 4978 21 ( ( -LRB- cord-023095-4dannjjm 4978 22 AOAC AOAC NNP cord-023095-4dannjjm 4978 23 , , , cord-023095-4dannjjm 4978 24 1995 1995 CD cord-023095-4dannjjm 4978 25 ) ) -RRB- cord-023095-4dannjjm 4978 26 and and CC cord-023095-4dannjjm 4978 27 used use VBN cord-023095-4dannjjm 4978 28 for for IN cord-023095-4dannjjm 4978 29 BE BE NNP cord-023095-4dannjjm 4978 30 calculation calculation NN cord-023095-4dannjjm 4978 31 . . . cord-023095-4dannjjm 4979 1 Dog Dog NNP cord-023095-4dannjjm 4979 2 's 's POS cord-023095-4dannjjm 4979 3 acid acid NN cord-023095-4dannjjm 4979 4 - - HYPH cord-023095-4dannjjm 4979 5 basic basic JJ cord-023095-4dannjjm 4979 6 status status NN cord-023095-4dannjjm 4979 7 was be VBD cord-023095-4dannjjm 4979 8 studied study VBN cord-023095-4dannjjm 4979 9 by by IN cord-023095-4dannjjm 4979 10 blood blood NN cord-023095-4dannjjm 4979 11 gas gas NN cord-023095-4dannjjm 4979 12 analysis analysis NN cord-023095-4dannjjm 4979 13 of of IN cord-023095-4dannjjm 4979 14 venous venous JJ cord-023095-4dannjjm 4979 15 blood blood NN cord-023095-4dannjjm 4979 16 , , , cord-023095-4dannjjm 4979 17 at at IN cord-023095-4dannjjm 4979 18 8:00h 8:00h CD cord-023095-4dannjjm 4979 19 ( ( -LRB- cord-023095-4dannjjm 4979 20 pre pre JJ cord-023095-4dannjjm 4979 21 feeding feeding NN cord-023095-4dannjjm 4979 22 ) ) -RRB- cord-023095-4dannjjm 4979 23 and and CC cord-023095-4dannjjm 4979 24 6 6 CD cord-023095-4dannjjm 4979 25 hours hour NNS cord-023095-4dannjjm 4979 26 after after IN cord-023095-4dannjjm 4979 27 meal meal NN cord-023095-4dannjjm 4979 28 . . . cord-023095-4dannjjm 4980 1 A a DT cord-023095-4dannjjm 4980 2 dose dose RB cord-023095-4dannjjm 4980 3 - - HYPH cord-023095-4dannjjm 4980 4 dependent dependent JJ cord-023095-4dannjjm 4980 5 reduction reduction NN cord-023095-4dannjjm 4980 6 of of IN cord-023095-4dannjjm 4980 7 urinary urinary JJ cord-023095-4dannjjm 4980 8 pH pH NNP cord-023095-4dannjjm 4980 9 was be VBD cord-023095-4dannjjm 4980 10 verified verify VBN cord-023095-4dannjjm 4980 11 for for IN cord-023095-4dannjjm 4980 12 both both DT cord-023095-4dannjjm 4980 13 compounds compound NNS cord-023095-4dannjjm 4980 14 ( ( -LRB- cord-023095-4dannjjm 4980 15 P p NN cord-023095-4dannjjm 4980 16 o o NN cord-023095-4dannjjm 4980 17 0.01 0.01 CD cord-023095-4dannjjm 4980 18 ) ) -RRB- cord-023095-4dannjjm 4980 19 . . . cord-023095-4dannjjm 4981 1 Blood blood NN cord-023095-4dannjjm 4981 2 bicarbonate bicarbonate NN cord-023095-4dannjjm 4981 3 ( ( -LRB- cord-023095-4dannjjm 4981 4 r r NN cord-023095-4dannjjm 4981 5 5 5 CD cord-023095-4dannjjm 4981 6 0.98 0.98 CD cord-023095-4dannjjm 4981 7 ; ; : cord-023095-4dannjjm 4981 8 P p NN cord-023095-4dannjjm 4981 9 o o NN cord-023095-4dannjjm 4981 10 0.01 0.01 CD cord-023095-4dannjjm 4981 11 ) ) -RRB- cord-023095-4dannjjm 4981 12 , , , cord-023095-4dannjjm 4981 13 and and CC cord-023095-4dannjjm 4981 14 blood blood NN cord-023095-4dannjjm 4981 15 base base NN cord-023095-4dannjjm 4981 16 excess excess NN cord-023095-4dannjjm 4982 1 ( ( -LRB- cord-023095-4dannjjm 4982 2 r r NN cord-023095-4dannjjm 4982 3 5 5 CD cord-023095-4dannjjm 4982 4 0.75 0.75 CD cord-023095-4dannjjm 4982 5 ; ; : cord-023095-4dannjjm 4982 6 P p NN cord-023095-4dannjjm 4982 7 o o NN cord-023095-4dannjjm 4982 8 0.01 0.01 CD cord-023095-4dannjjm 4982 9 ) ) -RRB- cord-023095-4dannjjm 4982 10 were be VBD cord-023095-4dannjjm 4982 11 highly highly RB cord-023095-4dannjjm 4982 12 correlated correlate VBN cord-023095-4dannjjm 4982 13 with with IN cord-023095-4dannjjm 4982 14 food food NN cord-023095-4dannjjm 4982 15 BE be VB cord-023095-4dannjjm 4982 16 . . . cord-023095-4dannjjm 4983 1 Acidemia Acidemia NNP cord-023095-4dannjjm 4983 2 and and CC cord-023095-4dannjjm 4983 3 reduced reduce VBN cord-023095-4dannjjm 4983 4 blood blood NN cord-023095-4dannjjm 4983 5 BE be VB cord-023095-4dannjjm 4983 6 were be VBD cord-023095-4dannjjm 4983 7 verified verify VBN cord-023095-4dannjjm 4983 8 in in IN cord-023095-4dannjjm 4983 9 diets diet NNS cord-023095-4dannjjm 4983 10 with with IN cord-023095-4dannjjm 4983 11 BE be VB cord-023095-4dannjjm 4983 12 close close JJ cord-023095-4dannjjm 4983 13 to to IN cord-023095-4dannjjm 4983 14 zero zero CD cord-023095-4dannjjm 4983 15 ( ( -LRB- cord-023095-4dannjjm 4983 16 higher high JJR cord-023095-4dannjjm 4983 17 dose dose NN cord-023095-4dannjjm 4983 18 of of IN cord-023095-4dannjjm 4983 19 both both DT cord-023095-4dannjjm 4983 20 compounds compound NNS cord-023095-4dannjjm 4983 21 , , , cord-023095-4dannjjm 4983 22 or or CC cord-023095-4dannjjm 4983 23 4 4 CD cord-023095-4dannjjm 4983 24 6.6 6.6 CD cord-023095-4dannjjm 4983 25 g g NN cord-023095-4dannjjm 4983 26 / / SYM cord-023095-4dannjjm 4983 27 kg kg NN cord-023095-4dannjjm 4983 28 of of IN cord-023095-4dannjjm 4983 29 S S NNP cord-023095-4dannjjm 4983 30 ) ) -RRB- cord-023095-4dannjjm 4983 31 , , , cord-023095-4dannjjm 4983 32 resulting result VBG cord-023095-4dannjjm 4983 33 in in IN cord-023095-4dannjjm 4983 34 daily daily JJ cord-023095-4dannjjm 4983 35 or or CC cord-023095-4dannjjm 4983 36 each each DT cord-023095-4dannjjm 4983 37 other other JJ cord-023095-4dannjjm 4983 38 day day NN cord-023095-4dannjjm 4983 39 vomiting vomit VBG cord-023095-4dannjjm 4983 40 episodes episode NNS cord-023095-4dannjjm 4983 41 in in IN cord-023095-4dannjjm 4983 42 the the DT cord-023095-4dannjjm 4983 43 dogs dog NNS cord-023095-4dannjjm 4983 44 . . . cord-023095-4dannjjm 4984 1 Ataxia ataxia JJ cord-023095-4dannjjm 4984 2 , , , cord-023095-4dannjjm 4984 3 seizures seizure NNS cord-023095-4dannjjm 4984 4 , , , cord-023095-4dannjjm 4984 5 and and CC cord-023095-4dannjjm 4984 6 vomiting vomiting NN cord-023095-4dannjjm 4984 7 were be VBD cord-023095-4dannjjm 4984 8 previously previously RB cord-023095-4dannjjm 4984 9 describe describe JJ cord-023095-4dannjjm 4984 10 in in IN cord-023095-4dannjjm 4984 11 dogs dog NNS cord-023095-4dannjjm 4984 12 fed feed VBD cord-023095-4dannjjm 4984 13 47 47 CD cord-023095-4dannjjm 4984 14 g g NN cord-023095-4dannjjm 4984 15 / / SYM cord-023095-4dannjjm 4984 16 kg kg NN cord-023095-4dannjjm 4984 17 of of IN cord-023095-4dannjjm 4984 18 methionine methionine NN cord-023095-4dannjjm 4984 19 , , , cord-023095-4dannjjm 4984 20 but but CC cord-023095-4dannjjm 4984 21 our -PRON- PRP$ cord-023095-4dannjjm 4984 22 results result NNS cord-023095-4dannjjm 4984 23 suggest suggest VBP cord-023095-4dannjjm 4984 24 that that IN cord-023095-4dannjjm 4984 25 a a DT cord-023095-4dannjjm 4984 26 much much RB cord-023095-4dannjjm 4984 27 lower low JJR cord-023095-4dannjjm 4984 28 value value NN cord-023095-4dannjjm 4984 29 ( ( -LRB- cord-023095-4dannjjm 4984 30 27.7 27.7 CD cord-023095-4dannjjm 4984 31 g g NN cord-023095-4dannjjm 4984 32 / / SYM cord-023095-4dannjjm 4984 33 kg kg NNP cord-023095-4dannjjm 4984 34 ) ) -RRB- cord-023095-4dannjjm 4984 35 was be VBD cord-023095-4dannjjm 4984 36 toxic toxic JJ cord-023095-4dannjjm 4984 37 and and CC cord-023095-4dannjjm 4984 38 that that IN cord-023095-4dannjjm 4984 39 the the DT cord-023095-4dannjjm 4984 40 safe safe JJ cord-023095-4dannjjm 4984 41 upper upper JJ cord-023095-4dannjjm 4984 42 limit limit NN cord-023095-4dannjjm 4984 43 should should MD cord-023095-4dannjjm 4984 44 be be VB cord-023095-4dannjjm 4984 45 between between IN cord-023095-4dannjjm 4984 46 this this DT cord-023095-4dannjjm 4984 47 value value NN cord-023095-4dannjjm 4984 48 and and CC cord-023095-4dannjjm 4984 49 15.7 15.7 CD cord-023095-4dannjjm 4984 50 g g NN cord-023095-4dannjjm 4984 51 / / SYM cord-023095-4dannjjm 4984 52 kg kg NNP cord-023095-4dannjjm 4985 1 ( ( -LRB- cord-023095-4dannjjm 4985 2 the the DT cord-023095-4dannjjm 4985 3 lower lower RBR cord-023095-4dannjjm 4985 4 evaluated evaluate VBN cord-023095-4dannjjm 4985 5 dose dose NN cord-023095-4dannjjm 4985 6 ) ) -RRB- cord-023095-4dannjjm 4985 7 . . . cord-023095-4dannjjm 4986 1 In in IN cord-023095-4dannjjm 4986 2 people people NNS cord-023095-4dannjjm 4986 3 with with IN cord-023095-4dannjjm 4986 4 chronic chronic JJ cord-023095-4dannjjm 4986 5 kidney kidney NN cord-023095-4dannjjm 4986 6 disease disease NN cord-023095-4dannjjm 4986 7 and and CC cord-023095-4dannjjm 4986 8 heart heart NN cord-023095-4dannjjm 4986 9 failure failure NN cord-023095-4dannjjm 4986 10 , , , cord-023095-4dannjjm 4986 11 obesity obesity NN cord-023095-4dannjjm 4986 12 is be VBZ cord-023095-4dannjjm 4986 13 associated associate VBN cord-023095-4dannjjm 4986 14 with with IN cord-023095-4dannjjm 4986 15 longer long JJR cord-023095-4dannjjm 4986 16 survival survival NN cord-023095-4dannjjm 4986 17 times time NNS cord-023095-4dannjjm 4986 18 . . . cord-023095-4dannjjm 4987 1 This this DT cord-023095-4dannjjm 4987 2 association association NN cord-023095-4dannjjm 4987 3 , , , cord-023095-4dannjjm 4987 4 called call VBD cord-023095-4dannjjm 4987 5 the the DT cord-023095-4dannjjm 4987 6 " " `` cord-023095-4dannjjm 4987 7 obesity obesity NN cord-023095-4dannjjm 4987 8 paradox paradox NN cord-023095-4dannjjm 4987 9 , , , cord-023095-4dannjjm 4987 10 " " '' cord-023095-4dannjjm 4987 11 also also RB cord-023095-4dannjjm 4987 12 has have VBZ cord-023095-4dannjjm 4987 13 been be VBN cord-023095-4dannjjm 4987 14 recognized recognize VBN cord-023095-4dannjjm 4987 15 in in IN cord-023095-4dannjjm 4987 16 dogs dog NNS cord-023095-4dannjjm 4987 17 and and CC cord-023095-4dannjjm 4987 18 cats cat NNS cord-023095-4dannjjm 4987 19 with with IN cord-023095-4dannjjm 4987 20 heart heart NN cord-023095-4dannjjm 4987 21 failure failure NN cord-023095-4dannjjm 4987 22 . . . cord-023095-4dannjjm 4988 1 Excess excess JJ cord-023095-4dannjjm 4988 2 weight weight NN cord-023095-4dannjjm 4988 3 appears appear VBZ cord-023095-4dannjjm 4988 4 to to TO cord-023095-4dannjjm 4988 5 modulate modulate VB cord-023095-4dannjjm 4988 6 the the DT cord-023095-4dannjjm 4988 7 serious serious JJ cord-023095-4dannjjm 4988 8 deleterious deleterious JJ cord-023095-4dannjjm 4988 9 effects effect NNS cord-023095-4dannjjm 4988 10 of of IN cord-023095-4dannjjm 4988 11 muscle muscle NN cord-023095-4dannjjm 4988 12 loss loss NN cord-023095-4dannjjm 4988 13 in in IN cord-023095-4dannjjm 4988 14 these these DT cord-023095-4dannjjm 4988 15 diseases disease NNS cord-023095-4dannjjm 4988 16 . . . cord-023095-4dannjjm 4989 1 The the DT cord-023095-4dannjjm 4989 2 purpose purpose NN cord-023095-4dannjjm 4989 3 of of IN cord-023095-4dannjjm 4989 4 this this DT cord-023095-4dannjjm 4989 5 study study NN cord-023095-4dannjjm 4989 6 was be VBD cord-023095-4dannjjm 4989 7 to to TO cord-023095-4dannjjm 4989 8 determine determine VB cord-023095-4dannjjm 4989 9 the the DT cord-023095-4dannjjm 4989 10 effects effect NNS cord-023095-4dannjjm 4989 11 of of IN cord-023095-4dannjjm 4989 12 body body NN cord-023095-4dannjjm 4989 13 condition condition NN cord-023095-4dannjjm 4989 14 and and CC cord-023095-4dannjjm 4989 15 body body NN cord-023095-4dannjjm 4989 16 weight weight NN cord-023095-4dannjjm 4989 17 changes change NNS cord-023095-4dannjjm 4989 18 in in IN cord-023095-4dannjjm 4989 19 dogs dog NNS cord-023095-4dannjjm 4989 20 with with IN cord-023095-4dannjjm 4989 21 naturally naturally RB cord-023095-4dannjjm 4989 22 - - HYPH cord-023095-4dannjjm 4989 23 occurring occur VBG cord-023095-4dannjjm 4989 24 chronic chronic JJ cord-023095-4dannjjm 4989 25 kidney kidney NN cord-023095-4dannjjm 4989 26 disease disease NN cord-023095-4dannjjm 4989 27 ( ( -LRB- cord-023095-4dannjjm 4989 28 CKD CKD NNP cord-023095-4dannjjm 4989 29 ) ) -RRB- cord-023095-4dannjjm 4989 30 . . . cord-023095-4dannjjm 4990 1 Dogs dog NNS cord-023095-4dannjjm 4990 2 diagnosed diagnose VBD cord-023095-4dannjjm 4990 3 with with IN cord-023095-4dannjjm 4990 4 ! ! . cord-023095-4dannjjm 4991 1 IRIS IRIS NNP cord-023095-4dannjjm 4991 2 stage stage NN cord-023095-4dannjjm 4991 3 II II NNP cord-023095-4dannjjm 4991 4 CKD CKD NNP cord-023095-4dannjjm 4991 5 between between IN cord-023095-4dannjjm 4991 6 2008 2008 CD cord-023095-4dannjjm 4991 7 and and CC cord-023095-4dannjjm 4991 8 2009 2009 CD cord-023095-4dannjjm 4991 9 at at IN cord-023095-4dannjjm 4992 1 Iowa Iowa NNP cord-023095-4dannjjm 4992 2 State State NNP cord-023095-4dannjjm 4992 3 University University NNP cord-023095-4dannjjm 4992 4 and and CC cord-023095-4dannjjm 4992 5 Tufts Tufts NNP cord-023095-4dannjjm 4992 6 Cummings Cummings NNP cord-023095-4dannjjm 4992 7 School School NNP cord-023095-4dannjjm 4992 8 of of IN cord-023095-4dannjjm 4992 9 Veterinary Veterinary NNP cord-023095-4dannjjm 4992 10 Medicine Medicine NNP cord-023095-4dannjjm 4992 11 were be VBD cord-023095-4dannjjm 4992 12 eligible eligible JJ cord-023095-4dannjjm 4992 13 for for IN cord-023095-4dannjjm 4992 14 the the DT cord-023095-4dannjjm 4992 15 study study NN cord-023095-4dannjjm 4992 16 . . . cord-023095-4dannjjm 4993 1 Dogs Dogs NNP cord-023095-4dannjjm 4993 2 o o NN cord-023095-4dannjjm 4993 3 1 1 CD cord-023095-4dannjjm 4993 4 year year NN cord-023095-4dannjjm 4993 5 of of IN cord-023095-4dannjjm 4993 6 age age NN cord-023095-4dannjjm 4993 7 and and CC cord-023095-4dannjjm 4993 8 those those DT cord-023095-4dannjjm 4993 9 with with IN cord-023095-4dannjjm 4993 10 acute acute JJ cord-023095-4dannjjm 4993 11 renal renal JJ cord-023095-4dannjjm 4993 12 failure failure NN cord-023095-4dannjjm 4993 13 or or CC cord-023095-4dannjjm 4993 14 suspected suspect VBN cord-023095-4dannjjm 4993 15 congenital congenital JJ cord-023095-4dannjjm 4993 16 renal renal JJ cord-023095-4dannjjm 4993 17 diseases disease NNS cord-023095-4dannjjm 4993 18 were be VBD cord-023095-4dannjjm 4993 19 excluded exclude VBN cord-023095-4dannjjm 4993 20 . . . cord-023095-4dannjjm 4994 1 Medical medical JJ cord-023095-4dannjjm 4994 2 records record NNS cord-023095-4dannjjm 4994 3 were be VBD cord-023095-4dannjjm 4994 4 reviewed review VBN cord-023095-4dannjjm 4994 5 using use VBG cord-023095-4dannjjm 4994 6 a a DT cord-023095-4dannjjm 4994 7 standardized standardized JJ cord-023095-4dannjjm 4994 8 data data NN cord-023095-4dannjjm 4994 9 form form NN cord-023095-4dannjjm 4994 10 , , , cord-023095-4dannjjm 4994 11 and and CC cord-023095-4dannjjm 4994 12 data datum NNS cord-023095-4dannjjm 4994 13 were be VBD cord-023095-4dannjjm 4994 14 collected collect VBN cord-023095-4dannjjm 4994 15 for for IN cord-023095-4dannjjm 4994 16 initial initial JJ cord-023095-4dannjjm 4994 17 body body NN cord-023095-4dannjjm 4994 18 weight weight NN cord-023095-4dannjjm 4994 19 and and CC cord-023095-4dannjjm 4994 20 body body NN cord-023095-4dannjjm 4994 21 condition condition NN cord-023095-4dannjjm 4994 22 score score NN cord-023095-4dannjjm 4994 23 ( ( -LRB- cord-023095-4dannjjm 4994 24 BCS BCS NNP cord-023095-4dannjjm 4994 25 , , , cord-023095-4dannjjm 4994 26 1 1 CD cord-023095-4dannjjm 4994 27 - - SYM cord-023095-4dannjjm 4994 28 9 9 CD cord-023095-4dannjjm 4994 29 scale scale NN cord-023095-4dannjjm 4994 30 ) ) -RRB- cord-023095-4dannjjm 4994 31 , , , cord-023095-4dannjjm 4994 32 clinicopathologic clinicopathologic JJ cord-023095-4dannjjm 4994 33 values value NNS cord-023095-4dannjjm 4994 34 , , , cord-023095-4dannjjm 4994 35 changes change NNS cord-023095-4dannjjm 4994 36 in in IN cord-023095-4dannjjm 4994 37 body body NN cord-023095-4dannjjm 4994 38 weight weight NN cord-023095-4dannjjm 4994 39 and and CC cord-023095-4dannjjm 4994 40 BCS BCS NNP cord-023095-4dannjjm 4994 41 , , , cord-023095-4dannjjm 4994 42 comorbidities comorbiditie NNS cord-023095-4dannjjm 4994 43 , , , cord-023095-4dannjjm 4994 44 and and CC cord-023095-4dannjjm 4994 45 treatments treatment NNS cord-023095-4dannjjm 4994 46 . . . cord-023095-4dannjjm 4995 1 Dogs dog NNS cord-023095-4dannjjm 4995 2 were be VBD cord-023095-4dannjjm 4995 3 classified classify VBN cord-023095-4dannjjm 4995 4 as as IN cord-023095-4dannjjm 4995 5 underweight underweight JJ cord-023095-4dannjjm 4995 6 ( ( -LRB- cord-023095-4dannjjm 4995 7 BCS BCS NNP cord-023095-4dannjjm 4995 8 5 5 CD cord-023095-4dannjjm 4995 9 1 1 CD cord-023095-4dannjjm 4995 10 - - SYM cord-023095-4dannjjm 4995 11 3 3 CD cord-023095-4dannjjm 4995 12 ) ) -RRB- cord-023095-4dannjjm 4995 13 , , , cord-023095-4dannjjm 4995 14 moderate moderate JJ cord-023095-4dannjjm 4995 15 weight weight NN cord-023095-4dannjjm 4995 16 ( ( -LRB- cord-023095-4dannjjm 4995 17 BCS BCS NNP cord-023095-4dannjjm 4995 18 5 5 CD cord-023095-4dannjjm 4995 19 4 4 CD cord-023095-4dannjjm 4995 20 - - SYM cord-023095-4dannjjm 4995 21 6 6 CD cord-023095-4dannjjm 4995 22 ) ) -RRB- cord-023095-4dannjjm 4995 23 , , , cord-023095-4dannjjm 4995 24 or or CC cord-023095-4dannjjm 4995 25 overweight overweight JJ cord-023095-4dannjjm 4995 26 ( ( -LRB- cord-023095-4dannjjm 4995 27 BCS BCS NNP cord-023095-4dannjjm 4995 28 5 5 CD cord-023095-4dannjjm 4995 29 7 7 CD cord-023095-4dannjjm 4995 30 - - SYM cord-023095-4dannjjm 4995 31 9 9 CD cord-023095-4dannjjm 4995 32 ) ) -RRB- cord-023095-4dannjjm 4995 33 . . . cord-023095-4dannjjm 4996 1 A a DT cord-023095-4dannjjm 4996 2 change change NN cord-023095-4dannjjm 4996 3 in in IN cord-023095-4dannjjm 4996 4 body body NN cord-023095-4dannjjm 4996 5 weight weight NN cord-023095-4dannjjm 4996 6 was be VBD cord-023095-4dannjjm 4996 7 defined define VBN cord-023095-4dannjjm 4996 8 as as IN cord-023095-4dannjjm 4996 9 4 4 CD cord-023095-4dannjjm 4996 10 0.2 0.2 CD cord-023095-4dannjjm 4996 11 kg kg NNS cord-023095-4dannjjm 4996 12 . . . cord-023095-4dannjjm 4997 1 Survival survival NN cord-023095-4dannjjm 4997 2 times time NNS cord-023095-4dannjjm 4997 3 were be VBD cord-023095-4dannjjm 4997 4 determined determine VBN cord-023095-4dannjjm 4997 5 for for IN cord-023095-4dannjjm 4997 6 all all DT cord-023095-4dannjjm 4997 7 dogs dog NNS cord-023095-4dannjjm 4997 8 that that WDT cord-023095-4dannjjm 4997 9 were be VBD cord-023095-4dannjjm 4997 10 discharged discharge VBN cord-023095-4dannjjm 4997 11 from from IN cord-023095-4dannjjm 4997 12 the the DT cord-023095-4dannjjm 4997 13 hospital hospital NN cord-023095-4dannjjm 4997 14 and and CC cord-023095-4dannjjm 4997 15 lived live VBD cord-023095-4dannjjm 4997 16 4 4 CD cord-023095-4dannjjm 4997 17 1 1 CD cord-023095-4dannjjm 4997 18 day day NN cord-023095-4dannjjm 4997 19 . . . cord-023095-4dannjjm 4998 1 Associations association NNS cord-023095-4dannjjm 4998 2 between between IN cord-023095-4dannjjm 4998 3 survival survival NN cord-023095-4dannjjm 4998 4 and and CC cord-023095-4dannjjm 4998 5 BCS BCS NNP cord-023095-4dannjjm 4998 6 or or CC cord-023095-4dannjjm 4998 7 body body NN cord-023095-4dannjjm 4998 8 weight weight NN cord-023095-4dannjjm 4998 9 changes change NNS cord-023095-4dannjjm 4998 10 were be VBD cord-023095-4dannjjm 4998 11 analyzed analyze VBN cord-023095-4dannjjm 4998 12 using use VBG cord-023095-4dannjjm 4998 13 Cox Cox NNP cord-023095-4dannjjm 4998 14 proportional proportional JJ cord-023095-4dannjjm 4998 15 hazards hazard NNS cord-023095-4dannjjm 4998 16 models model NNS cord-023095-4dannjjm 4998 17 . . . cord-023095-4dannjjm 4999 1 One one CD cord-023095-4dannjjm 4999 2 hundred hundred CD cord-023095-4dannjjm 4999 3 two two CD cord-023095-4dannjjm 4999 4 dogs dog NNS cord-023095-4dannjjm 4999 5 were be VBD cord-023095-4dannjjm 4999 6 enrolled enrol VBN cord-023095-4dannjjm 4999 7 in in IN cord-023095-4dannjjm 4999 8 the the DT cord-023095-4dannjjm 4999 9 study study NN cord-023095-4dannjjm 4999 10 . . . cord-023095-4dannjjm 5000 1 At at IN cord-023095-4dannjjm 5000 2 the the DT cord-023095-4dannjjm 5000 3 time time NN cord-023095-4dannjjm 5000 4 of of IN cord-023095-4dannjjm 5000 5 diagnosis diagnosis NN cord-023095-4dannjjm 5000 6 , , , cord-023095-4dannjjm 5000 7 21 21 CD cord-023095-4dannjjm 5000 8 dogs dog NNS cord-023095-4dannjjm 5000 9 were be VBD cord-023095-4dannjjm 5000 10 classified classify VBN cord-023095-4dannjjm 5000 11 as as IN cord-023095-4dannjjm 5000 12 IRIS IRIS NNP cord-023095-4dannjjm 5000 13 Stage Stage NNP cord-023095-4dannjjm 5000 14 II II NNP cord-023095-4dannjjm 5000 15 , , , cord-023095-4dannjjm 5000 16 57 57 CD cord-023095-4dannjjm 5000 17 dogs dog NNS cord-023095-4dannjjm 5000 18 were be VBD cord-023095-4dannjjm 5000 19 Stage Stage NNP cord-023095-4dannjjm 5000 20 III III NNP cord-023095-4dannjjm 5000 21 and and CC cord-023095-4dannjjm 5000 22 24 24 CD cord-023095-4dannjjm 5000 23 dogs dog NNS cord-023095-4dannjjm 5001 1 were be VBD cord-023095-4dannjjm 5001 2 Stage Stage NNP cord-023095-4dannjjm 5001 3 IV IV NNP cord-023095-4dannjjm 5001 4 . . . cord-023095-4dannjjm 5002 1 Median median JJ cord-023095-4dannjjm 5002 2 body body NN cord-023095-4dannjjm 5002 3 weight weight NN cord-023095-4dannjjm 5002 4 at at IN cord-023095-4dannjjm 5002 5 baseline baseline NN cord-023095-4dannjjm 5002 6 was be VBD cord-023095-4dannjjm 5002 7 18.7 18.7 CD cord-023095-4dannjjm 5002 8 kg kg NNS cord-023095-4dannjjm 5002 9 ( ( -LRB- cord-023095-4dannjjm 5002 10 range range NN cord-023095-4dannjjm 5002 11 , , , cord-023095-4dannjjm 5002 12 2.4 2.4 CD cord-023095-4dannjjm 5002 13 - - SYM cord-023095-4dannjjm 5002 14 50.1 50.1 CD cord-023095-4dannjjm 5002 15 kg kg NNS cord-023095-4dannjjm 5002 16 ) ) -RRB- cord-023095-4dannjjm 5002 17 . . . cord-023095-4dannjjm 5003 1 For for IN cord-023095-4dannjjm 5003 2 dogs dog NNS cord-023095-4dannjjm 5003 3 with with IN cord-023095-4dannjjm 5003 4 body body NN cord-023095-4dannjjm 5003 5 condition condition NN cord-023095-4dannjjm 5003 6 scores score NNS cord-023095-4dannjjm 5003 7 recorded record VBD cord-023095-4dannjjm 5003 8 ( ( -LRB- cord-023095-4dannjjm 5003 9 n n NN cord-023095-4dannjjm 5003 10 5 5 CD cord-023095-4dannjjm 5003 11 74 74 CD cord-023095-4dannjjm 5003 12 ) ) -RRB- cord-023095-4dannjjm 5003 13 , , , cord-023095-4dannjjm 5003 14 13 13 CD cord-023095-4dannjjm 5003 15 were be VBD cord-023095-4dannjjm 5003 16 underweight underweight JJ cord-023095-4dannjjm 5003 17 ( ( -LRB- cord-023095-4dannjjm 5003 18 18 18 CD cord-023095-4dannjjm 5003 19 % % NN cord-023095-4dannjjm 5003 20 ) ) -RRB- cord-023095-4dannjjm 5003 21 , , , cord-023095-4dannjjm 5003 22 51 51 CD cord-023095-4dannjjm 5003 23 were be VBD cord-023095-4dannjjm 5003 24 moderate moderate JJ cord-023095-4dannjjm 5003 25 ( ( -LRB- cord-023095-4dannjjm 5003 26 69 69 CD cord-023095-4dannjjm 5003 27 % % NN cord-023095-4dannjjm 5003 28 ) ) -RRB- cord-023095-4dannjjm 5003 29 , , , cord-023095-4dannjjm 5003 30 and and CC cord-023095-4dannjjm 5003 31 10 10 CD cord-023095-4dannjjm 5003 32 were be VBD cord-023095-4dannjjm 5003 33 overweight overweight JJ cord-023095-4dannjjm 5003 34 ( ( -LRB- cord-023095-4dannjjm 5003 35 14 14 CD cord-023095-4dannjjm 5003 36 % % NN cord-023095-4dannjjm 5003 37 ) ) -RRB- cord-023095-4dannjjm 5003 38 . . . cord-023095-4dannjjm 5004 1 For for IN cord-023095-4dannjjm 5004 2 dogs dog NNS cord-023095-4dannjjm 5004 3 that that WDT cord-023095-4dannjjm 5004 4 had have VBD cord-023095-4dannjjm 5004 5 at at RB cord-023095-4dannjjm 5004 6 least least RBS cord-023095-4dannjjm 5004 7 two two CD cord-023095-4dannjjm 5004 8 body body NN cord-023095-4dannjjm 5004 9 weights weight NNS cord-023095-4dannjjm 5004 10 recorded record VBN cord-023095-4dannjjm 5004 11 over over IN cord-023095-4dannjjm 5004 12 the the DT cord-023095-4dannjjm 5004 13 course course NN cord-023095-4dannjjm 5004 14 of of IN cord-023095-4dannjjm 5004 15 their -PRON- PRP$ cord-023095-4dannjjm 5004 16 disease disease NN cord-023095-4dannjjm 5004 17 , , , cord-023095-4dannjjm 5004 18 22 22 CD cord-023095-4dannjjm 5004 19 gained gain VBD cord-023095-4dannjjm 5004 20 weight weight NN cord-023095-4dannjjm 5004 21 , , , cord-023095-4dannjjm 5004 22 46 46 CD cord-023095-4dannjjm 5004 23 lost lose VBN cord-023095-4dannjjm 5004 24 weight weight NN cord-023095-4dannjjm 5004 25 , , , cord-023095-4dannjjm 5004 26 and and CC cord-023095-4dannjjm 5004 27 10 10 CD cord-023095-4dannjjm 5004 28 had have VBD cord-023095-4dannjjm 5004 29 no no DT cord-023095-4dannjjm 5004 30 change change NN cord-023095-4dannjjm 5004 31 in in IN cord-023095-4dannjjm 5004 32 weight weight NN cord-023095-4dannjjm 5004 33 . . . cord-023095-4dannjjm 5005 1 Changes change NNS cord-023095-4dannjjm 5005 2 in in IN cord-023095-4dannjjm 5005 3 body body NN cord-023095-4dannjjm 5005 4 weight weight NN cord-023095-4dannjjm 5005 5 were be VBD cord-023095-4dannjjm 5005 6 not not RB cord-023095-4dannjjm 5005 7 associated associate VBN cord-023095-4dannjjm 5005 8 with with IN cord-023095-4dannjjm 5005 9 survival survival NN cord-023095-4dannjjm 5005 10 ; ; : cord-023095-4dannjjm 5005 11 however however RB cord-023095-4dannjjm 5005 12 , , , cord-023095-4dannjjm 5005 13 BCS BCS NNP cord-023095-4dannjjm 5005 14 at at IN cord-023095-4dannjjm 5005 15 the the DT cord-023095-4dannjjm 5005 16 time time NN cord-023095-4dannjjm 5005 17 of of IN cord-023095-4dannjjm 5005 18 diagnosis diagnosis NN cord-023095-4dannjjm 5005 19 was be VBD cord-023095-4dannjjm 5005 20 significantly significantly RB cord-023095-4dannjjm 5005 21 associated associate VBN cord-023095-4dannjjm 5005 22 with with IN cord-023095-4dannjjm 5005 23 survival survival NN cord-023095-4dannjjm 5005 24 . . . cord-023095-4dannjjm 5006 1 Dogs dog NNS cord-023095-4dannjjm 5006 2 classified classify VBD cord-023095-4dannjjm 5006 3 as as IN cord-023095-4dannjjm 5006 4 underweight underweight JJ cord-023095-4dannjjm 5006 5 had have VBD cord-023095-4dannjjm 5006 6 a a DT cord-023095-4dannjjm 5006 7 significantly significantly RB cord-023095-4dannjjm 5006 8 shorter short JJR cord-023095-4dannjjm 5006 9 survival survival NN cord-023095-4dannjjm 5006 10 time time NN cord-023095-4dannjjm 5006 11 compared compare VBN cord-023095-4dannjjm 5006 12 to to IN cord-023095-4dannjjm 5006 13 both both CC cord-023095-4dannjjm 5006 14 moderate moderate JJ cord-023095-4dannjjm 5006 15 ( ( -LRB- cord-023095-4dannjjm 5006 16 P p NN cord-023095-4dannjjm 5006 17 o o NN cord-023095-4dannjjm 5006 18 0.001 0.001 CD cord-023095-4dannjjm 5006 19 ) ) -RRB- cord-023095-4dannjjm 5006 20 and and CC cord-023095-4dannjjm 5006 21 overweight overweight JJ cord-023095-4dannjjm 5006 22 dogs dog NNS cord-023095-4dannjjm 5006 23 ( ( -LRB- cord-023095-4dannjjm 5006 24 P p NN cord-023095-4dannjjm 5006 25 o o NN cord-023095-4dannjjm 5006 26 0.001 0.001 CD cord-023095-4dannjjm 5006 27 ) ) -RRB- cord-023095-4dannjjm 5006 28 . . . cord-023095-4dannjjm 5007 1 These these DT cord-023095-4dannjjm 5007 2 results result NNS cord-023095-4dannjjm 5007 3 suggest suggest VBP cord-023095-4dannjjm 5007 4 that that IN cord-023095-4dannjjm 5007 5 body body NN cord-023095-4dannjjm 5007 6 condition condition NN cord-023095-4dannjjm 5007 7 is be VBZ cord-023095-4dannjjm 5007 8 an an DT cord-023095-4dannjjm 5007 9 important important JJ cord-023095-4dannjjm 5007 10 consideration consideration NN cord-023095-4dannjjm 5007 11 in in IN cord-023095-4dannjjm 5007 12 dogs dog NNS cord-023095-4dannjjm 5007 13 with with IN cord-023095-4dannjjm 5007 14 acquired acquire VBN cord-023095-4dannjjm 5007 15 chronic chronic JJ cord-023095-4dannjjm 5007 16 kidney kidney NN cord-023095-4dannjjm 5007 17 disease disease NN cord-023095-4dannjjm 5007 18 . . . cord-023095-4dannjjm 5008 1 Further further JJ cord-023095-4dannjjm 5008 2 studies study NNS cord-023095-4dannjjm 5008 3 are be VBP cord-023095-4dannjjm 5008 4 warranted warrant VBN cord-023095-4dannjjm 5008 5 to to TO cord-023095-4dannjjm 5008 6 evaluate evaluate VB cord-023095-4dannjjm 5008 7 the the DT cord-023095-4dannjjm 5008 8 relationship relationship NN cord-023095-4dannjjm 5008 9 between between IN cord-023095-4dannjjm 5008 10 obesity obesity NN cord-023095-4dannjjm 5008 11 and and CC cord-023095-4dannjjm 5008 12 longer long JJR cord-023095-4dannjjm 5008 13 survival survival NN cord-023095-4dannjjm 5008 14 in in IN cord-023095-4dannjjm 5008 15 dogs dog NNS cord-023095-4dannjjm 5008 16 with with IN cord-023095-4dannjjm 5008 17 CKD CKD NNP cord-023095-4dannjjm 5008 18 . . . cord-023095-4dannjjm 5009 1 Protein protein NN cord-023095-4dannjjm 5009 2 restriction restriction NN cord-023095-4dannjjm 5009 3 is be VBZ cord-023095-4dannjjm 5009 4 the the DT cord-023095-4dannjjm 5009 5 cornerstone cornerstone NN cord-023095-4dannjjm 5009 6 of of IN cord-023095-4dannjjm 5009 7 dietary dietary JJ cord-023095-4dannjjm 5009 8 management management NN cord-023095-4dannjjm 5009 9 of of IN cord-023095-4dannjjm 5009 10 kidney kidney NN cord-023095-4dannjjm 5009 11 disease disease NN cord-023095-4dannjjm 5009 12 . . . cord-023095-4dannjjm 5010 1 The the DT cord-023095-4dannjjm 5010 2 National National NNP cord-023095-4dannjjm 5010 3 Research Research NNP cord-023095-4dannjjm 5010 4 Council Council NNP cord-023095-4dannjjm 5010 5 recommends recommend VBZ cord-023095-4dannjjm 5010 6 20 20 CD cord-023095-4dannjjm 5010 7 % % NN cord-023095-4dannjjm 5010 8 crude crude JJ cord-023095-4dannjjm 5010 9 protein protein NN cord-023095-4dannjjm 5010 10 and and CC cord-023095-4dannjjm 5010 11 the the DT cord-023095-4dannjjm 5010 12 American American NNP cord-023095-4dannjjm 5010 13 Association Association NNP cord-023095-4dannjjm 5010 14 of of IN cord-023095-4dannjjm 5010 15 Feed Feed NNP cord-023095-4dannjjm 5010 16 Control Control NNP cord-023095-4dannjjm 5010 17 Officials Officials NNPS cord-023095-4dannjjm 5010 18 ( ( -LRB- cord-023095-4dannjjm 5010 19 AAFCO AAFCO NNP cord-023095-4dannjjm 5010 20 ) ) -RRB- cord-023095-4dannjjm 5010 21 recommends recommend VBZ cord-023095-4dannjjm 5010 22 a a DT cord-023095-4dannjjm 5010 23 minimum minimum NN cord-023095-4dannjjm 5010 24 of of IN cord-023095-4dannjjm 5010 25 26 26 CD cord-023095-4dannjjm 5010 26 % % NN cord-023095-4dannjjm 5010 27 crude crude JJ cord-023095-4dannjjm 5010 28 protein protein NN cord-023095-4dannjjm 5010 29 for for IN cord-023095-4dannjjm 5010 30 maintenance maintenance NN cord-023095-4dannjjm 5010 31 for for IN cord-023095-4dannjjm 5010 32 healthy healthy JJ cord-023095-4dannjjm 5010 33 adult adult NN cord-023095-4dannjjm 5010 34 cats cat NNS cord-023095-4dannjjm 5010 35 . . . cord-023095-4dannjjm 5011 1 Protein protein NN cord-023095-4dannjjm 5011 2 requirement requirement NN cord-023095-4dannjjm 5011 3 is be VBZ cord-023095-4dannjjm 5011 4 unknown unknown JJ cord-023095-4dannjjm 5011 5 for for IN cord-023095-4dannjjm 5011 6 adult adult NN cord-023095-4dannjjm 5011 7 cats cat NNS cord-023095-4dannjjm 5011 8 with with IN cord-023095-4dannjjm 5011 9 kidney kidney NN cord-023095-4dannjjm 5011 10 disease disease NN cord-023095-4dannjjm 5011 11 . . . cord-023095-4dannjjm 5012 1 Most most RBS cord-023095-4dannjjm 5012 2 commercially commercially RB cord-023095-4dannjjm 5012 3 produced produce VBN cord-023095-4dannjjm 5012 4 cat cat NN cord-023095-4dannjjm 5012 5 foods food NNS cord-023095-4dannjjm 5012 6 for for IN cord-023095-4dannjjm 5012 7 adult adult NN cord-023095-4dannjjm 5012 8 maintenance maintenance NN cord-023095-4dannjjm 5012 9 contains contain VBZ cord-023095-4dannjjm 5012 10 30 30 CD cord-023095-4dannjjm 5012 11 % % NN cord-023095-4dannjjm 5012 12 or or CC cord-023095-4dannjjm 5012 13 more more JJR cord-023095-4dannjjm 5012 14 crude crude JJ cord-023095-4dannjjm 5012 15 protein protein NN cord-023095-4dannjjm 5012 16 on on IN cord-023095-4dannjjm 5012 17 a a DT cord-023095-4dannjjm 5012 18 dry dry JJ cord-023095-4dannjjm 5012 19 matter matter NN cord-023095-4dannjjm 5012 20 basis basis NN cord-023095-4dannjjm 5012 21 . . . cord-023095-4dannjjm 5013 1 A a DT cord-023095-4dannjjm 5013 2 typical typical JJ cord-023095-4dannjjm 5013 3 therapeutic therapeutic JJ cord-023095-4dannjjm 5013 4 food food NN cord-023095-4dannjjm 5013 5 for for IN cord-023095-4dannjjm 5013 6 cats cat NNS cord-023095-4dannjjm 5013 7 with with IN cord-023095-4dannjjm 5013 8 kidney kidney NN cord-023095-4dannjjm 5013 9 disease disease NN cord-023095-4dannjjm 5013 10 contains contain VBZ cord-023095-4dannjjm 5013 11 about about IN cord-023095-4dannjjm 5013 12 28 28 CD cord-023095-4dannjjm 5013 13 % % NN cord-023095-4dannjjm 5013 14 crude crude JJ cord-023095-4dannjjm 5013 15 protein protein NN cord-023095-4dannjjm 5013 16 . . . cord-023095-4dannjjm 5014 1 The the DT cord-023095-4dannjjm 5014 2 objective objective NN cord-023095-4dannjjm 5014 3 of of IN cord-023095-4dannjjm 5014 4 the the DT cord-023095-4dannjjm 5014 5 present present JJ cord-023095-4dannjjm 5014 6 study study NN cord-023095-4dannjjm 5014 7 was be VBD cord-023095-4dannjjm 5014 8 to to TO cord-023095-4dannjjm 5014 9 investigate investigate VB cord-023095-4dannjjm 5014 10 whether whether IN cord-023095-4dannjjm 5014 11 dietary dietary JJ cord-023095-4dannjjm 5014 12 crude crude JJ cord-023095-4dannjjm 5014 13 protein protein NN cord-023095-4dannjjm 5014 14 at at IN cord-023095-4dannjjm 5014 15 28.5 28.5 CD cord-023095-4dannjjm 5014 16 % % NN cord-023095-4dannjjm 5014 17 would would MD cord-023095-4dannjjm 5014 18 be be VB cord-023095-4dannjjm 5014 19 adequate adequate JJ cord-023095-4dannjjm 5014 20 for for IN cord-023095-4dannjjm 5014 21 the the DT cord-023095-4dannjjm 5014 22 maintenance maintenance NN cord-023095-4dannjjm 5014 23 for for IN cord-023095-4dannjjm 5014 24 adult adult NN cord-023095-4dannjjm 5014 25 cats cat NNS cord-023095-4dannjjm 5014 26 with with IN cord-023095-4dannjjm 5014 27 impaired impaired JJ cord-023095-4dannjjm 5014 28 kidney kidney NN cord-023095-4dannjjm 5014 29 function function NN cord-023095-4dannjjm 5014 30 . . . cord-023095-4dannjjm 5015 1 Seven seven CD cord-023095-4dannjjm 5015 2 adult adult NN cord-023095-4dannjjm 5015 3 cats cat NNS cord-023095-4dannjjm 5015 4 , , , cord-023095-4dannjjm 5015 5 3 3 CD cord-023095-4dannjjm 5015 6 female female NN cord-023095-4dannjjm 5015 7 and and CC cord-023095-4dannjjm 5015 8 4 4 CD cord-023095-4dannjjm 5015 9 male male NN cord-023095-4dannjjm 5015 10 , , , cord-023095-4dannjjm 5015 11 with with IN cord-023095-4dannjjm 5015 12 age age NN cord-023095-4dannjjm 5015 13 ranging range VBG cord-023095-4dannjjm 5015 14 from from IN cord-023095-4dannjjm 5015 15 5 5 CD cord-023095-4dannjjm 5015 16 to to IN cord-023095-4dannjjm 5015 17 13.7 13.7 CD cord-023095-4dannjjm 5015 18 years year NNS cord-023095-4dannjjm 5015 19 old old JJ cord-023095-4dannjjm 5015 20 ( ( -LRB- cord-023095-4dannjjm 5015 21 mean mean VB cord-023095-4dannjjm 5015 22 : : : cord-023095-4dannjjm 5015 23 8.1 8.1 CD cord-023095-4dannjjm 5015 24 years year NNS cord-023095-4dannjjm 5015 25 ) ) -RRB- cord-023095-4dannjjm 5015 26 were be VBD cord-023095-4dannjjm 5015 27 used use VBN cord-023095-4dannjjm 5015 28 in in IN cord-023095-4dannjjm 5015 29 the the DT cord-023095-4dannjjm 5015 30 study study NN cord-023095-4dannjjm 5015 31 . . . cord-023095-4dannjjm 5016 1 All all DT cord-023095-4dannjjm 5016 2 cats cat NNS cord-023095-4dannjjm 5016 3 had have VBD cord-023095-4dannjjm 5016 4 elevated elevate VBN cord-023095-4dannjjm 5016 5 serum serum NN cord-023095-4dannjjm 5016 6 creatinine creatinine NN cord-023095-4dannjjm 5016 7 concentration concentration NN cord-023095-4dannjjm 5016 8 ( ( -LRB- cord-023095-4dannjjm 5016 9 4 4 CD cord-023095-4dannjjm 5016 10 1.6 1.6 CD cord-023095-4dannjjm 5016 11 mg mg NNP cord-023095-4dannjjm 5016 12 / / SYM cord-023095-4dannjjm 5016 13 dl dl NN cord-023095-4dannjjm 5016 14 , , , cord-023095-4dannjjm 5016 15 range range NN cord-023095-4dannjjm 5016 16 : : : cord-023095-4dannjjm 5016 17 1.61 1.61 CD cord-023095-4dannjjm 5016 18 - - SYM cord-023095-4dannjjm 5016 19 2.10 2.10 CD cord-023095-4dannjjm 5016 20 mg mg NNP cord-023095-4dannjjm 5016 21 / / SYM cord-023095-4dannjjm 5016 22 dl dl NNP cord-023095-4dannjjm 5016 23 ) ) -RRB- cord-023095-4dannjjm 5016 24 and and CC cord-023095-4dannjjm 5016 25 reduced reduce VBN cord-023095-4dannjjm 5016 26 glomerula glomerula JJ cord-023095-4dannjjm 5016 27 filtration filtration NN cord-023095-4dannjjm 5016 28 rate rate NN cord-023095-4dannjjm 5016 29 ( ( -LRB- cord-023095-4dannjjm 5016 30 mean mean VB cord-023095-4dannjjm 5016 31 : : : cord-023095-4dannjjm 5016 32 32 32 CD cord-023095-4dannjjm 5016 33 % % NN cord-023095-4dannjjm 5016 34 reduction reduction NN cord-023095-4dannjjm 5016 35 ; ; : cord-023095-4dannjjm 5016 36 range range NN cord-023095-4dannjjm 5016 37 : : : cord-023095-4dannjjm 5016 38 12 12 CD cord-023095-4dannjjm 5016 39 - - SYM cord-023095-4dannjjm 5016 40 60 60 CD cord-023095-4dannjjm 5016 41 % % NN cord-023095-4dannjjm 5016 42 reduction reduction NN cord-023095-4dannjjm 5016 43 ) ) -RRB- cord-023095-4dannjjm 5016 44 during during IN cord-023095-4dannjjm 5016 45 the the DT cord-023095-4dannjjm 5016 46 study study NN cord-023095-4dannjjm 5016 47 . . . cord-023095-4dannjjm 5017 1 They -PRON- PRP cord-023095-4dannjjm 5017 2 did do VBD cord-023095-4dannjjm 5017 3 not not RB cord-023095-4dannjjm 5017 4 have have VB cord-023095-4dannjjm 5017 5 other other JJ cord-023095-4dannjjm 5017 6 systematic systematic JJ cord-023095-4dannjjm 5017 7 diseases disease NNS cord-023095-4dannjjm 5017 8 , , , cord-023095-4dannjjm 5017 9 e.g. e.g. RB cord-023095-4dannjjm 5017 10 , , , cord-023095-4dannjjm 5017 11 hyperthyroidism hyperthyroidism NN cord-023095-4dannjjm 5017 12 , , , cord-023095-4dannjjm 5017 13 at at IN cord-023095-4dannjjm 5017 14 the the DT cord-023095-4dannjjm 5017 15 beginning beginning NN cord-023095-4dannjjm 5017 16 of of IN cord-023095-4dannjjm 5017 17 the the DT cord-023095-4dannjjm 5017 18 study study NN cord-023095-4dannjjm 5017 19 . . . cord-023095-4dannjjm 5018 1 Cats cat NNS cord-023095-4dannjjm 5018 2 were be VBD cord-023095-4dannjjm 5018 3 fed feed VBN cord-023095-4dannjjm 5018 4 an an DT cord-023095-4dannjjm 5018 5 expanded expand VBN cord-023095-4dannjjm 5018 6 dry dry JJ cord-023095-4dannjjm 5018 7 food food NN cord-023095-4dannjjm 5018 8 made make VBN cord-023095-4dannjjm 5018 9 with with IN cord-023095-4dannjjm 5018 10 ingredients ingredient NNS cord-023095-4dannjjm 5018 11 commonly commonly RB cord-023095-4dannjjm 5018 12 used use VBN cord-023095-4dannjjm 5018 13 in in IN cord-023095-4dannjjm 5018 14 commercial commercial JJ cord-023095-4dannjjm 5018 15 dry dry JJ cord-023095-4dannjjm 5018 16 cat cat NN cord-023095-4dannjjm 5018 17 foods food NNS cord-023095-4dannjjm 5018 18 . . . cord-023095-4dannjjm 5019 1 The the DT cord-023095-4dannjjm 5019 2 food food NN cord-023095-4dannjjm 5019 3 contained contain VBD cord-023095-4dannjjm 5019 4 28.5 28.5 CD cord-023095-4dannjjm 5019 5 % % NN cord-023095-4dannjjm 5019 6 crude crude JJ cord-023095-4dannjjm 5019 7 protein protein NN cord-023095-4dannjjm 5019 8 ( ( -LRB- cord-023095-4dannjjm 5019 9 chemical chemical NN cord-023095-4dannjjm 5019 10 analysis analysis NN cord-023095-4dannjjm 5019 11 ) ) -RRB- cord-023095-4dannjjm 5019 12 and and CC cord-023095-4dannjjm 5019 13 4366 4366 CD cord-023095-4dannjjm 5019 14 kcal kcal NNP cord-023095-4dannjjm 5019 15 / / SYM cord-023095-4dannjjm 5019 16 kg kg NNP cord-023095-4dannjjm 5019 17 ( ( -LRB- cord-023095-4dannjjm 5019 18 calculated calculate VBN cord-023095-4dannjjm 5019 19 ) ) -RRB- cord-023095-4dannjjm 5019 20 on on IN cord-023095-4dannjjm 5019 21 a a DT cord-023095-4dannjjm 5019 22 dry dry JJ cord-023095-4dannjjm 5019 23 matter matter NN cord-023095-4dannjjm 5019 24 basis basis NN cord-023095-4dannjjm 5019 25 , , , cord-023095-4dannjjm 5019 26 or or CC cord-023095-4dannjjm 5019 27 65.3 65.3 CD cord-023095-4dannjjm 5019 28 g g NN cord-023095-4dannjjm 5019 29 protein/1000 protein/1000 NNS cord-023095-4dannjjm 5019 30 kcal kcal NNP cord-023095-4dannjjm 5019 31 . . . cord-023095-4dannjjm 5020 1 Each each DT cord-023095-4dannjjm 5020 2 essential essential JJ cord-023095-4dannjjm 5020 3 amino amino NN cord-023095-4dannjjm 5020 4 acid acid NN cord-023095-4dannjjm 5020 5 in in IN cord-023095-4dannjjm 5020 6 the the DT cord-023095-4dannjjm 5020 7 food food NN cord-023095-4dannjjm 5020 8 was be VBD cord-023095-4dannjjm 5020 9 at at RB cord-023095-4dannjjm 5020 10 least least RBS cord-023095-4dannjjm 5020 11 130 130 CD cord-023095-4dannjjm 5020 12 % % NN cord-023095-4dannjjm 5020 13 of of IN cord-023095-4dannjjm 5020 14 that that DT cord-023095-4dannjjm 5020 15 recommended recommend VBN cord-023095-4dannjjm 5020 16 by by IN cord-023095-4dannjjm 5020 17 AAFCO AAFCO NNP cord-023095-4dannjjm 5020 18 . . . cord-023095-4dannjjm 5021 1 Other other JJ cord-023095-4dannjjm 5021 2 nutrients nutrient NNS cord-023095-4dannjjm 5021 3 in in IN cord-023095-4dannjjm 5021 4 the the DT cord-023095-4dannjjm 5021 5 food food NN cord-023095-4dannjjm 5021 6 also also RB cord-023095-4dannjjm 5021 7 exceeded exceed VBD cord-023095-4dannjjm 5021 8 AAFCO AAFCO NNP cord-023095-4dannjjm 5021 9 's 's POS cord-023095-4dannjjm 5021 10 recommendations recommendation NNS cord-023095-4dannjjm 5021 11 for for IN cord-023095-4dannjjm 5021 12 maintenance maintenance NN cord-023095-4dannjjm 5021 13 for for IN cord-023095-4dannjjm 5021 14 adult adult NN cord-023095-4dannjjm 5021 15 cats cat NNS cord-023095-4dannjjm 5021 16 . . . cord-023095-4dannjjm 5022 1 Cats cat NNS cord-023095-4dannjjm 5022 2 were be VBD cord-023095-4dannjjm 5022 3 fed feed VBN cord-023095-4dannjjm 5022 4 the the DT cord-023095-4dannjjm 5022 5 food food NN cord-023095-4dannjjm 5022 6 for for IN cord-023095-4dannjjm 5022 7 30 30 CD cord-023095-4dannjjm 5022 8 weeks week NNS cord-023095-4dannjjm 5022 9 . . . cord-023095-4dannjjm 5023 1 Lean lean JJ cord-023095-4dannjjm 5023 2 body body NN cord-023095-4dannjjm 5023 3 mass mass NN cord-023095-4dannjjm 5023 4 ( ( -LRB- cord-023095-4dannjjm 5023 5 dual dual NNP cord-023095-4dannjjm 5023 6 x x NN cord-023095-4dannjjm 5023 7 - - NN cord-023095-4dannjjm 5023 8 ray ray NNP cord-023095-4dannjjm 5023 9 absorptionmetry absorptionmetry NN cord-023095-4dannjjm 5023 10 ; ; : cord-023095-4dannjjm 5023 11 Hologic Hologic NNP cord-023095-4dannjjm 5023 12 , , , cord-023095-4dannjjm 5023 13 Hologic Hologic NNP cord-023095-4dannjjm 5023 14 , , , cord-023095-4dannjjm 5023 15 Inc Inc NNP cord-023095-4dannjjm 5023 16 , , , cord-023095-4dannjjm 5023 17 MA MA NNP cord-023095-4dannjjm 5023 18 ) ) -RRB- cord-023095-4dannjjm 5023 19 and and CC cord-023095-4dannjjm 5023 20 serum serum NN cord-023095-4dannjjm 5023 21 albumin albumin NN cord-023095-4dannjjm 5023 22 concentration concentration NN cord-023095-4dannjjm 5023 23 were be VBD cord-023095-4dannjjm 5023 24 measured measure VBN cord-023095-4dannjjm 5023 25 periodically periodically RB cord-023095-4dannjjm 5023 26 to to TO cord-023095-4dannjjm 5023 27 monitor monitor VB cord-023095-4dannjjm 5023 28 protein protein NN cord-023095-4dannjjm 5023 29 status status NN cord-023095-4dannjjm 5023 30 of of IN cord-023095-4dannjjm 5023 31 cats cat NNS cord-023095-4dannjjm 5023 32 . . . cord-023095-4dannjjm 5024 1 The the DT cord-023095-4dannjjm 5024 2 average average JJ cord-023095-4dannjjm 5024 3 lean lean JJ cord-023095-4dannjjm 5024 4 body body NN cord-023095-4dannjjm 5024 5 mass mass NN cord-023095-4dannjjm 5024 6 ( ( -LRB- cord-023095-4dannjjm 5024 7 mean mean VB cord-023095-4dannjjm 5024 8 AE AE NNP cord-023095-4dannjjm 5024 9 SD SD NNP cord-023095-4dannjjm 5024 10 ) ) -RRB- cord-023095-4dannjjm 5024 11 was be VBD cord-023095-4dannjjm 5024 12 3.63 3.63 CD cord-023095-4dannjjm 5024 13 AE AE NNP cord-023095-4dannjjm 5024 14 0.82 0.82 CD cord-023095-4dannjjm 5024 15 kg kg NN cord-023095-4dannjjm 5024 16 , , , cord-023095-4dannjjm 5024 17 3.72 3.72 CD cord-023095-4dannjjm 5024 18 AE AE NNP cord-023095-4dannjjm 5024 19 0.85 0.85 CD cord-023095-4dannjjm 5024 20 kg kg NNS cord-023095-4dannjjm 5024 21 , , , cord-023095-4dannjjm 5024 22 3.74 3.74 CD cord-023095-4dannjjm 5024 23 AE AE NNP cord-023095-4dannjjm 5024 24 0.84 0.84 CD cord-023095-4dannjjm 5024 25 kg kg NNS cord-023095-4dannjjm 5024 26 , , , cord-023095-4dannjjm 5024 27 and and CC cord-023095-4dannjjm 5024 28 3.75 3.75 CD cord-023095-4dannjjm 5024 29 AE AE NNP cord-023095-4dannjjm 5024 30 0.89 0.89 CD cord-023095-4dannjjm 5024 31 kg kg NNS cord-023095-4dannjjm 5024 32 in in IN cord-023095-4dannjjm 5024 33 weeks week NNS cord-023095-4dannjjm 5024 34 3 3 CD cord-023095-4dannjjm 5024 35 , , , cord-023095-4dannjjm 5024 36 11 11 CD cord-023095-4dannjjm 5024 37 , , , cord-023095-4dannjjm 5024 38 17 17 CD cord-023095-4dannjjm 5024 39 , , , cord-023095-4dannjjm 5024 40 and and CC cord-023095-4dannjjm 5024 41 30 30 CD cord-023095-4dannjjm 5024 42 of of IN cord-023095-4dannjjm 5024 43 the the DT cord-023095-4dannjjm 5024 44 study study NN cord-023095-4dannjjm 5024 45 , , , cord-023095-4dannjjm 5024 46 respectively respectively RB cord-023095-4dannjjm 5024 47 . . . cord-023095-4dannjjm 5025 1 Paired paired JJ cord-023095-4dannjjm 5025 2 t t NN cord-023095-4dannjjm 5025 3 - - HYPH cord-023095-4dannjjm 5025 4 test test NN cord-023095-4dannjjm 5025 5 did do VBD cord-023095-4dannjjm 5025 6 not not RB cord-023095-4dannjjm 5025 7 detect detect VB cord-023095-4dannjjm 5025 8 statistical statistical JJ cord-023095-4dannjjm 5025 9 difference difference NN cord-023095-4dannjjm 5025 10 ( ( -LRB- cord-023095-4dannjjm 5025 11 p p NN cord-023095-4dannjjm 5025 12 4 4 CD cord-023095-4dannjjm 5025 13 0.05 0.05 CD cord-023095-4dannjjm 5025 14 ) ) -RRB- cord-023095-4dannjjm 5025 15 when when WRB cord-023095-4dannjjm 5025 16 comparing compare VBG cord-023095-4dannjjm 5025 17 the the DT cord-023095-4dannjjm 5025 18 lean lean JJ cord-023095-4dannjjm 5025 19 body body NN cord-023095-4dannjjm 5025 20 mass mass NN cord-023095-4dannjjm 5025 21 in in IN cord-023095-4dannjjm 5025 22 weeks week NNS cord-023095-4dannjjm 5025 23 3 3 CD cord-023095-4dannjjm 5025 24 versus versus IN cord-023095-4dannjjm 5025 25 weeks week NNS cord-023095-4dannjjm 5025 26 11 11 CD cord-023095-4dannjjm 5025 27 , , , cord-023095-4dannjjm 5025 28 17 17 CD cord-023095-4dannjjm 5025 29 , , , cord-023095-4dannjjm 5025 30 and and CC cord-023095-4dannjjm 5025 31 30 30 CD cord-023095-4dannjjm 5025 32 , , , cord-023095-4dannjjm 5025 33 respectively respectively RB cord-023095-4dannjjm 5025 34 . . . cord-023095-4dannjjm 5026 1 Serum serum NN cord-023095-4dannjjm 5026 2 albumin albumin NN cord-023095-4dannjjm 5026 3 concentration concentration NN cord-023095-4dannjjm 5026 4 were be VBD cord-023095-4dannjjm 5026 5 within within IN cord-023095-4dannjjm 5026 6 the the DT cord-023095-4dannjjm 5026 7 normal normal JJ cord-023095-4dannjjm 5026 8 reference reference NN cord-023095-4dannjjm 5026 9 range range NN cord-023095-4dannjjm 5026 10 during during IN cord-023095-4dannjjm 5026 11 the the DT cord-023095-4dannjjm 5026 12 study study NN cord-023095-4dannjjm 5026 13 ( ( -LRB- cord-023095-4dannjjm 5026 14 mean mean VB cord-023095-4dannjjm 5026 15 AE AE NNP cord-023095-4dannjjm 5026 16 SD SD NNP cord-023095-4dannjjm 5026 17 : : : cord-023095-4dannjjm 5026 18 3.04 3.04 CD cord-023095-4dannjjm 5026 19 AE AE NNP cord-023095-4dannjjm 5026 20 0.35 0.35 CD cord-023095-4dannjjm 5026 21 % % NN cord-023095-4dannjjm 5026 22 , , , cord-023095-4dannjjm 5026 23 2.80 2.80 CD cord-023095-4dannjjm 5026 24 AE AE NNP cord-023095-4dannjjm 5026 25 0.35 0.35 CD cord-023095-4dannjjm 5026 26 % % NN cord-023095-4dannjjm 5026 27 , , , cord-023095-4dannjjm 5026 28 3.04 3.04 CD cord-023095-4dannjjm 5026 29 AE AE NNP cord-023095-4dannjjm 5026 30 0.32 0.32 CD cord-023095-4dannjjm 5026 31 % % NN cord-023095-4dannjjm 5026 32 , , , cord-023095-4dannjjm 5026 33 and and CC cord-023095-4dannjjm 5026 34 3.07 3.07 CD cord-023095-4dannjjm 5026 35 AE AE NNP cord-023095-4dannjjm 5026 36 0.40 0.40 CD cord-023095-4dannjjm 5026 37 % % NN cord-023095-4dannjjm 5026 38 in in IN cord-023095-4dannjjm 5026 39 weeks week NNS cord-023095-4dannjjm 5026 40 3 3 CD cord-023095-4dannjjm 5026 41 , , , cord-023095-4dannjjm 5026 42 11 11 CD cord-023095-4dannjjm 5026 43 , , , cord-023095-4dannjjm 5026 44 17 17 CD cord-023095-4dannjjm 5026 45 , , , cord-023095-4dannjjm 5026 46 and and CC cord-023095-4dannjjm 5026 47 30 30 CD cord-023095-4dannjjm 5026 48 , , , cord-023095-4dannjjm 5026 49 respectively respectively RB cord-023095-4dannjjm 5026 50 ) ) -RRB- cord-023095-4dannjjm 5026 51 . . . cord-023095-4dannjjm 5027 1 These these DT cord-023095-4dannjjm 5027 2 data datum NNS cord-023095-4dannjjm 5027 3 show show VBP cord-023095-4dannjjm 5027 4 that that IN cord-023095-4dannjjm 5027 5 28.5 28.5 CD cord-023095-4dannjjm 5027 6 % % NN cord-023095-4dannjjm 5027 7 dietary dietary JJ cord-023095-4dannjjm 5027 8 crude crude JJ cord-023095-4dannjjm 5027 9 protein protein NN cord-023095-4dannjjm 5027 10 in in IN cord-023095-4dannjjm 5027 11 a a DT cord-023095-4dannjjm 5027 12 dry dry JJ cord-023095-4dannjjm 5027 13 food food NN cord-023095-4dannjjm 5027 14 with with IN cord-023095-4dannjjm 5027 15 4366 4366 CD cord-023095-4dannjjm 5027 16 kcal kcal NNP cord-023095-4dannjjm 5027 17 / / SYM cord-023095-4dannjjm 5027 18 kg kg NNS cord-023095-4dannjjm 5027 19 on on IN cord-023095-4dannjjm 5027 20 a a DT cord-023095-4dannjjm 5027 21 dry dry JJ cord-023095-4dannjjm 5027 22 matter matter NN cord-023095-4dannjjm 5027 23 basis basis NN cord-023095-4dannjjm 5027 24 , , , cord-023095-4dannjjm 5027 25 or or CC cord-023095-4dannjjm 5027 26 65.3 65.3 CD cord-023095-4dannjjm 5027 27 g g NN cord-023095-4dannjjm 5027 28 protein/1000 protein/1000 NNS cord-023095-4dannjjm 5027 29 kcal kcal NNP cord-023095-4dannjjm 5027 30 , , , cord-023095-4dannjjm 5027 31 is be VBZ cord-023095-4dannjjm 5027 32 adequate adequate JJ cord-023095-4dannjjm 5027 33 for for IN cord-023095-4dannjjm 5027 34 maintenance maintenance NN cord-023095-4dannjjm 5027 35 for for IN cord-023095-4dannjjm 5027 36 cats cat NNS cord-023095-4dannjjm 5027 37 with with IN cord-023095-4dannjjm 5027 38 impaired impaired JJ cord-023095-4dannjjm 5027 39 kidney kidney NN cord-023095-4dannjjm 5027 40 function function NN cord-023095-4dannjjm 5027 41 . . . cord-023095-4dannjjm 5028 1 In in IN cord-023095-4dannjjm 5028 2 humans human NNS cord-023095-4dannjjm 5028 3 , , , cord-023095-4dannjjm 5028 4 several several JJ cord-023095-4dannjjm 5028 5 disease disease NN cord-023095-4dannjjm 5028 6 conditions condition NNS cord-023095-4dannjjm 5028 7 exist exist VBP cord-023095-4dannjjm 5028 8 that that WDT cord-023095-4dannjjm 5028 9 involve involve VBP cord-023095-4dannjjm 5028 10 abnormal abnormal JJ cord-023095-4dannjjm 5028 11 patterns pattern NNS cord-023095-4dannjjm 5028 12 of of IN cord-023095-4dannjjm 5028 13 polyunsaturated polyunsaturated JJ cord-023095-4dannjjm 5028 14 fatty fatty JJ cord-023095-4dannjjm 5028 15 acids acid NNS cord-023095-4dannjjm 5028 16 and and CC cord-023095-4dannjjm 5028 17 similar similar JJ cord-023095-4dannjjm 5028 18 abnormalities abnormality NNS cord-023095-4dannjjm 5028 19 may may MD cord-023095-4dannjjm 5028 20 be be VB cord-023095-4dannjjm 5028 21 present present JJ cord-023095-4dannjjm 5028 22 in in IN cord-023095-4dannjjm 5028 23 companion companion NN cord-023095-4dannjjm 5028 24 animals animal NNS cord-023095-4dannjjm 5028 25 . . . cord-023095-4dannjjm 5029 1 Indeed indeed RB cord-023095-4dannjjm 5029 2 there there EX cord-023095-4dannjjm 5029 3 have have VBP cord-023095-4dannjjm 5029 4 been be VBN cord-023095-4dannjjm 5029 5 reports report NNS cord-023095-4dannjjm 5029 6 of of IN cord-023095-4dannjjm 5029 7 decreased decrease VBN cord-023095-4dannjjm 5029 8 plasma plasma NN cord-023095-4dannjjm 5029 9 arachidonic arachidonic NN cord-023095-4dannjjm 5029 10 acid acid NN cord-023095-4dannjjm 5029 11 and and CC cord-023095-4dannjjm 5029 12 reduced reduce VBN cord-023095-4dannjjm 5029 13 delta-6 delta-6 NNP cord-023095-4dannjjm 5029 14 desaturase desaturase NN cord-023095-4dannjjm 5029 15 activities activity NNS cord-023095-4dannjjm 5029 16 in in IN cord-023095-4dannjjm 5029 17 dogs dog NNS cord-023095-4dannjjm 5029 18 with with IN cord-023095-4dannjjm 5029 19 atopy atopy NN cord-023095-4dannjjm 5029 20 and and CC cord-023095-4dannjjm 5029 21 other other JJ cord-023095-4dannjjm 5029 22 skin skin NN cord-023095-4dannjjm 5029 23 disorders disorder NNS cord-023095-4dannjjm 5029 24 . . . cord-023095-4dannjjm 5030 1 The the DT cord-023095-4dannjjm 5030 2 present present JJ cord-023095-4dannjjm 5030 3 study study NN cord-023095-4dannjjm 5030 4 investigated investigate VBD cord-023095-4dannjjm 5030 5 serum serum JJ cord-023095-4dannjjm 5030 6 fatty fatty JJ cord-023095-4dannjjm 5030 7 acid acid NN cord-023095-4dannjjm 5030 8 profiles profile NNS cord-023095-4dannjjm 5030 9 in in IN cord-023095-4dannjjm 5030 10 dogs dog NNS cord-023095-4dannjjm 5030 11 and and CC cord-023095-4dannjjm 5030 12 cats cat NNS cord-023095-4dannjjm 5030 13 presented present VBN cord-023095-4dannjjm 5030 14 to to IN cord-023095-4dannjjm 5030 15 the the DT cord-023095-4dannjjm 5030 16 Texas Texas NNP cord-023095-4dannjjm 5030 17 A&M A&M NNP cord-023095-4dannjjm 5030 18 University University NNP cord-023095-4dannjjm 5030 19 Veterinary Veterinary NNP cord-023095-4dannjjm 5030 20 Teaching Teaching NNP cord-023095-4dannjjm 5030 21 Hospital Hospital NNP cord-023095-4dannjjm 5030 22 , , , cord-023095-4dannjjm 5030 23 Clinical Clinical NNP cord-023095-4dannjjm 5030 24 Pathology Pathology NNP cord-023095-4dannjjm 5030 25 Laboratory Laboratory NNP cord-023095-4dannjjm 5030 26 over over IN cord-023095-4dannjjm 5030 27 the the DT cord-023095-4dannjjm 5030 28 past past JJ cord-023095-4dannjjm 5030 29 one one CD cord-023095-4dannjjm 5030 30 year year NN cord-023095-4dannjjm 5030 31 period period NN cord-023095-4dannjjm 5030 32 . . . cord-023095-4dannjjm 5031 1 Results result NNS cord-023095-4dannjjm 5031 2 were be VBD cord-023095-4dannjjm 5031 3 compared compare VBN cord-023095-4dannjjm 5031 4 with with IN cord-023095-4dannjjm 5031 5 normative normative JJ cord-023095-4dannjjm 5031 6 data datum NNS cord-023095-4dannjjm 5031 7 generated generate VBN cord-023095-4dannjjm 5031 8 among among IN cord-023095-4dannjjm 5031 9 dogs dog NNS cord-023095-4dannjjm 5031 10 and and CC cord-023095-4dannjjm 5031 11 cats cat NNS cord-023095-4dannjjm 5031 12 from from IN cord-023095-4dannjjm 5031 13 earlier early JJR cord-023095-4dannjjm 5031 14 feeding feeding NN cord-023095-4dannjjm 5031 15 studies study NNS cord-023095-4dannjjm 5031 16 . . . cord-023095-4dannjjm 5032 1 Sera Sera NNP cord-023095-4dannjjm 5032 2 used use VBD cord-023095-4dannjjm 5032 3 were be VBD cord-023095-4dannjjm 5032 4 residual residual JJ cord-023095-4dannjjm 5032 5 samples sample NNS cord-023095-4dannjjm 5032 6 submitted submit VBN cord-023095-4dannjjm 5032 7 to to IN cord-023095-4dannjjm 5032 8 the the DT cord-023095-4dannjjm 5032 9 laboratory laboratory NN cord-023095-4dannjjm 5032 10 for for IN cord-023095-4dannjjm 5032 11 other other JJ cord-023095-4dannjjm 5032 12 diagnostic diagnostic JJ cord-023095-4dannjjm 5032 13 procedures procedure NNS cord-023095-4dannjjm 5032 14 and and CC cord-023095-4dannjjm 5032 15 stored store VBD cord-023095-4dannjjm 5032 16 frozen frozen JJ cord-023095-4dannjjm 5032 17 for for IN cord-023095-4dannjjm 5032 18 no no DT cord-023095-4dannjjm 5032 19 more more JJR cord-023095-4dannjjm 5032 20 than than IN cord-023095-4dannjjm 5032 21 2 2 CD cord-023095-4dannjjm 5032 22 months month NNS cord-023095-4dannjjm 5032 23 after after IN cord-023095-4dannjjm 5032 24 collection collection NN cord-023095-4dannjjm 5032 25 . . . cord-023095-4dannjjm 5033 1 The the DT cord-023095-4dannjjm 5033 2 samples sample NNS cord-023095-4dannjjm 5033 3 were be VBD cord-023095-4dannjjm 5033 4 grouped group VBN cord-023095-4dannjjm 5033 5 according accord VBG cord-023095-4dannjjm 5033 6 to to IN cord-023095-4dannjjm 5033 7 presenting present VBG cord-023095-4dannjjm 5033 8 disorders disorder NNS cord-023095-4dannjjm 5033 9 involving involve VBG cord-023095-4dannjjm 5033 10 liver liver NN cord-023095-4dannjjm 5033 11 , , , cord-023095-4dannjjm 5033 12 kidney kidney NN cord-023095-4dannjjm 5033 13 , , , cord-023095-4dannjjm 5033 14 digestive digestive JJ cord-023095-4dannjjm 5033 15 , , , cord-023095-4dannjjm 5033 16 and and CC cord-023095-4dannjjm 5033 17 cardiac cardiac JJ cord-023095-4dannjjm 5033 18 diseases disease NNS cord-023095-4dannjjm 5033 19 . . . cord-023095-4dannjjm 5034 1 Total total JJ cord-023095-4dannjjm 5034 2 lipids lipid NNS cord-023095-4dannjjm 5034 3 were be VBD cord-023095-4dannjjm 5034 4 extracted extract VBN cord-023095-4dannjjm 5034 5 using use VBG cord-023095-4dannjjm 5034 6 chloroform chloroform NN cord-023095-4dannjjm 5034 7 : : : cord-023095-4dannjjm 5034 8 methanol methanol NN cord-023095-4dannjjm 5034 9 ( ( -LRB- cord-023095-4dannjjm 5034 10 2:1 2:1 CD cord-023095-4dannjjm 5034 11 v v NN cord-023095-4dannjjm 5034 12 / / SYM cord-023095-4dannjjm 5034 13 v v NN cord-023095-4dannjjm 5034 14 ) ) -RRB- cord-023095-4dannjjm 5034 15 and and CC cord-023095-4dannjjm 5034 16 fatty fatty JJ cord-023095-4dannjjm 5034 17 acid acid NN cord-023095-4dannjjm 5034 18 methyl methyl NN cord-023095-4dannjjm 5034 19 esters ester NNS cord-023095-4dannjjm 5034 20 were be VBD cord-023095-4dannjjm 5034 21 prepared prepare VBN cord-023095-4dannjjm 5034 22 for for IN cord-023095-4dannjjm 5034 23 capillary capillary JJ cord-023095-4dannjjm 5034 24 gas gas NN cord-023095-4dannjjm 5034 25 chromatography chromatography NN cord-023095-4dannjjm 5034 26 . . . cord-023095-4dannjjm 5035 1 Relative relative JJ cord-023095-4dannjjm 5035 2 percentage percentage NN cord-023095-4dannjjm 5035 3 distribution distribution NN cord-023095-4dannjjm 5035 4 of of IN cord-023095-4dannjjm 5035 5 individual individual JJ cord-023095-4dannjjm 5035 6 serum serum NN cord-023095-4dannjjm 5035 7 fatty fatty JJ cord-023095-4dannjjm 5035 8 acids acid NNS cord-023095-4dannjjm 5035 9 for for IN cord-023095-4dannjjm 5035 10 each each DT cord-023095-4dannjjm 5035 11 animal animal NN cord-023095-4dannjjm 5035 12 were be VBD cord-023095-4dannjjm 5035 13 then then RB cord-023095-4dannjjm 5035 14 compared compare VBN cord-023095-4dannjjm 5035 15 with with IN cord-023095-4dannjjm 5035 16 average average JJ cord-023095-4dannjjm 5035 17 normative normative JJ cord-023095-4dannjjm 5035 18 serum serum NN cord-023095-4dannjjm 5035 19 phospholipid phospholipid NN cord-023095-4dannjjm 5035 20 fatty fatty JJ cord-023095-4dannjjm 5035 21 acid acid NN cord-023095-4dannjjm 5035 22 values value NNS cord-023095-4dannjjm 5035 23 ( ( -LRB- cord-023095-4dannjjm 5035 24 dogs dog NNS cord-023095-4dannjjm 5035 25 , , , cord-023095-4dannjjm 5035 26 n n NN cord-023095-4dannjjm 5035 27 5 5 CD cord-023095-4dannjjm 5035 28 44 44 CD cord-023095-4dannjjm 5035 29 ; ; : cord-023095-4dannjjm 5035 30 cats cat NNS cord-023095-4dannjjm 5035 31 , , , cord-023095-4dannjjm 5035 32 n n NN cord-023095-4dannjjm 5035 33 5 5 CD cord-023095-4dannjjm 5035 34 29 29 CD cord-023095-4dannjjm 5035 35 ) ) -RRB- cord-023095-4dannjjm 5035 36 by by IN cord-023095-4dannjjm 5035 37 calculating calculate VBG cord-023095-4dannjjm 5035 38 the the DT cord-023095-4dannjjm 5035 39 ratio ratio NN cord-023095-4dannjjm 5035 40 of of IN cord-023095-4dannjjm 5035 41 the the DT cord-023095-4dannjjm 5035 42 value value NN cord-023095-4dannjjm 5035 43 in in IN cord-023095-4dannjjm 5035 44 the the DT cord-023095-4dannjjm 5035 45 diseased diseased JJ cord-023095-4dannjjm 5035 46 individual individual NN cord-023095-4dannjjm 5035 47 to to IN cord-023095-4dannjjm 5035 48 the the DT cord-023095-4dannjjm 5035 49 normal normal JJ cord-023095-4dannjjm 5035 50 mean mean JJ cord-023095-4dannjjm 5035 51 value value NN cord-023095-4dannjjm 5035 52 and and CC cord-023095-4dannjjm 5035 53 used use VBD cord-023095-4dannjjm 5035 54 as as IN cord-023095-4dannjjm 5035 55 an an DT cord-023095-4dannjjm 5035 56 index index NN cord-023095-4dannjjm 5035 57 of of IN cord-023095-4dannjjm 5035 58 normalcy normalcy NN cord-023095-4dannjjm 5035 59 . . . cord-023095-4dannjjm 5036 1 Normalcy normalcy NN cord-023095-4dannjjm 5036 2 ratios ratio NNS cord-023095-4dannjjm 5036 3 were be VBD cord-023095-4dannjjm 5036 4 then then RB cord-023095-4dannjjm 5036 5 plotted plot VBN cord-023095-4dannjjm 5036 6 on on IN cord-023095-4dannjjm 5036 7 a a DT cord-023095-4dannjjm 5036 8 logarithmic logarithmic JJ cord-023095-4dannjjm 5036 9 scale scale NN cord-023095-4dannjjm 5036 10 with with IN cord-023095-4dannjjm 5036 11 normal normal JJ cord-023095-4dannjjm 5036 12 at at IN cord-023095-4dannjjm 5036 13 1.0 1.0 CD cord-023095-4dannjjm 5036 14 . . . cord-023095-4dannjjm 5037 1 The the DT cord-023095-4dannjjm 5037 2 ratio ratio NN cord-023095-4dannjjm 5037 3 was be VBD cord-023095-4dannjjm 5037 4 then then RB cord-023095-4dannjjm 5037 5 compared compare VBN cord-023095-4dannjjm 5037 6 to to IN cord-023095-4dannjjm 5037 7 changes change NNS cord-023095-4dannjjm 5037 8 greater great JJR cord-023095-4dannjjm 5037 9 than than IN cord-023095-4dannjjm 5037 10 3 3 CD cord-023095-4dannjjm 5037 11 , , , cord-023095-4dannjjm 5037 12 2 2 CD cord-023095-4dannjjm 5037 13 and and CC cord-023095-4dannjjm 5037 14 1 1 CD cord-023095-4dannjjm 5037 15 standard standard JJ cord-023095-4dannjjm 5037 16 deviations deviation NNS cord-023095-4dannjjm 5037 17 of of IN cord-023095-4dannjjm 5037 18 the the DT cord-023095-4dannjjm 5037 19 normal normal JJ cord-023095-4dannjjm 5037 20 mean mean JJ cord-023095-4dannjjm 5037 21 values value NNS cord-023095-4dannjjm 5037 22 . . . cord-023095-4dannjjm 5038 1 In in IN cord-023095-4dannjjm 5038 2 this this DT cord-023095-4dannjjm 5038 3 way way NN cord-023095-4dannjjm 5038 4 a a DT cord-023095-4dannjjm 5038 5 graphical graphical JJ cord-023095-4dannjjm 5038 6 presentation presentation NN cord-023095-4dannjjm 5038 7 of of IN cord-023095-4dannjjm 5038 8 resultant resultant JJ cord-023095-4dannjjm 5038 9 values value NNS cord-023095-4dannjjm 5038 10 was be VBD cord-023095-4dannjjm 5038 11 obtained obtain VBN cord-023095-4dannjjm 5038 12 . . . cord-023095-4dannjjm 5039 1 Although although IN cord-023095-4dannjjm 5039 2 the the DT cord-023095-4dannjjm 5039 3 animals animal NNS cord-023095-4dannjjm 5039 4 had have VBD cord-023095-4dannjjm 5039 5 been be VBN cord-023095-4dannjjm 5039 6 fed feed VBN cord-023095-4dannjjm 5039 7 various various JJ cord-023095-4dannjjm 5039 8 commercial commercial JJ cord-023095-4dannjjm 5039 9 diets diet NNS cord-023095-4dannjjm 5039 10 and and CC cord-023095-4dannjjm 5039 11 some some DT cord-023095-4dannjjm 5039 12 home home NN cord-023095-4dannjjm 5039 13 - - HYPH cord-023095-4dannjjm 5039 14 prepared prepare VBN cord-023095-4dannjjm 5039 15 foods food NNS cord-023095-4dannjjm 5039 16 , , , cord-023095-4dannjjm 5039 17 a a DT cord-023095-4dannjjm 5039 18 number number NN cord-023095-4dannjjm 5039 19 of of IN cord-023095-4dannjjm 5039 20 noteworthy noteworthy JJ cord-023095-4dannjjm 5039 21 patterns pattern NNS cord-023095-4dannjjm 5039 22 emerged emerge VBD cord-023095-4dannjjm 5039 23 from from IN cord-023095-4dannjjm 5039 24 this this DT cord-023095-4dannjjm 5039 25 analysis analysis NN cord-023095-4dannjjm 5039 26 . . . cord-023095-4dannjjm 5040 1 Dogs dog NNS cord-023095-4dannjjm 5040 2 showed show VBD cord-023095-4dannjjm 5040 3 increased increase VBN cord-023095-4dannjjm 5040 4 linoleic linoleic NN cord-023095-4dannjjm 5040 5 acid acid NN cord-023095-4dannjjm 5040 6 , , , cord-023095-4dannjjm 5040 7 decreased decrease VBD cord-023095-4dannjjm 5040 8 arachidonic arachidonic JJ cord-023095-4dannjjm 5040 9 acid acid NN cord-023095-4dannjjm 5040 10 , , , cord-023095-4dannjjm 5040 11 increased increase VBD cord-023095-4dannjjm 5040 12 total total JJ cord-023095-4dannjjm 5040 13 monounsaturated monounsaturated NN cord-023095-4dannjjm 5040 14 and and CC cord-023095-4dannjjm 5040 15 decreased decrease VBD cord-023095-4dannjjm 5040 16 saturated saturated JJ cord-023095-4dannjjm 5040 17 fatty fatty JJ cord-023095-4dannjjm 5040 18 acids acid NNS cord-023095-4dannjjm 5040 19 at at IN cord-023095-4dannjjm 5040 20 P p NN cord-023095-4dannjjm 5040 21 o o NN cord-023095-4dannjjm 5040 22 0.001 0.001 CD cord-023095-4dannjjm 5040 23 ; ; : cord-023095-4dannjjm 5040 24 oleic oleic JJ cord-023095-4dannjjm 5040 25 acid acid NN cord-023095-4dannjjm 5040 26 was be VBD cord-023095-4dannjjm 5040 27 increased increase VBN cord-023095-4dannjjm 5040 28 at at IN cord-023095-4dannjjm 5040 29 p p NN cord-023095-4dannjjm 5040 30 o o NN cord-023095-4dannjjm 5040 31 0.01 0.01 CD cord-023095-4dannjjm 5040 32 . . . cord-023095-4dannjjm 5041 1 Remarkably remarkably RB cord-023095-4dannjjm 5041 2 , , , cord-023095-4dannjjm 5041 3 these these DT cord-023095-4dannjjm 5041 4 findings finding NNS cord-023095-4dannjjm 5041 5 were be VBD cord-023095-4dannjjm 5041 6 similar similar JJ cord-023095-4dannjjm 5041 7 for for IN cord-023095-4dannjjm 5041 8 all all DT cord-023095-4dannjjm 5041 9 canine canine JJ cord-023095-4dannjjm 5041 10 disease disease NN cord-023095-4dannjjm 5041 11 categories category NNS cord-023095-4dannjjm 5041 12 evaluated evaluate VBN cord-023095-4dannjjm 5041 13 ( ( -LRB- cord-023095-4dannjjm 5041 14 n n NN cord-023095-4dannjjm 5041 15 5 5 CD cord-023095-4dannjjm 5041 16 30 30 CD cord-023095-4dannjjm 5041 17 , , , cord-023095-4dannjjm 5041 18 heart heart NN cord-023095-4dannjjm 5041 19 ; ; : cord-023095-4dannjjm 5041 20 n n NN cord-023095-4dannjjm 5041 21 5 5 CD cord-023095-4dannjjm 5041 22 17 17 CD cord-023095-4dannjjm 5041 23 , , , cord-023095-4dannjjm 5041 24 kidney kidney NN cord-023095-4dannjjm 5041 25 ; ; : cord-023095-4dannjjm 5041 26 n n NN cord-023095-4dannjjm 5041 27 5 5 CD cord-023095-4dannjjm 5041 28 28 28 CD cord-023095-4dannjjm 5041 29 , , , cord-023095-4dannjjm 5041 30 liver liver NN cord-023095-4dannjjm 5041 31 , , , cord-023095-4dannjjm 5041 32 and and CC cord-023095-4dannjjm 5041 33 n n NN cord-023095-4dannjjm 5041 34 5 5 CD cord-023095-4dannjjm 5041 35 28 28 CD cord-023095-4dannjjm 5041 36 digestive digestive JJ cord-023095-4dannjjm 5041 37 disorders disorder NNS cord-023095-4dannjjm 5041 38 ) ) -RRB- cord-023095-4dannjjm 5041 39 . . . cord-023095-4dannjjm 5042 1 In in IN cord-023095-4dannjjm 5042 2 cats cat NNS cord-023095-4dannjjm 5042 3 , , , cord-023095-4dannjjm 5042 4 a a DT cord-023095-4dannjjm 5042 5 slight slight JJ cord-023095-4dannjjm 5042 6 decrease decrease NN cord-023095-4dannjjm 5042 7 in in IN cord-023095-4dannjjm 5042 8 arachidonic arachidonic JJ cord-023095-4dannjjm 5042 9 acid acid NN cord-023095-4dannjjm 5042 10 and and CC cord-023095-4dannjjm 5042 11 large large JJ cord-023095-4dannjjm 5042 12 decrease decrease NN cord-023095-4dannjjm 5042 13 in in IN cord-023095-4dannjjm 5042 14 22:0 22:0 CD cord-023095-4dannjjm 5042 15 was be VBD cord-023095-4dannjjm 5042 16 observed observe VBN cord-023095-4dannjjm 5042 17 but but CC cord-023095-4dannjjm 5042 18 only only RB cord-023095-4dannjjm 5042 19 in in IN cord-023095-4dannjjm 5042 20 heart heart NN cord-023095-4dannjjm 5042 21 disorders disorder NNS cord-023095-4dannjjm 5042 22 . . . cord-023095-4dannjjm 5043 1 By by IN cord-023095-4dannjjm 5043 2 contrast contrast NN cord-023095-4dannjjm 5043 3 , , , cord-023095-4dannjjm 5043 4 modest modest JJ cord-023095-4dannjjm 5043 5 elevations elevation NNS cord-023095-4dannjjm 5043 6 of of IN cord-023095-4dannjjm 5043 7 arachidonate arachidonate NNP cord-023095-4dannjjm 5043 8 were be VBD cord-023095-4dannjjm 5043 9 observed observe VBN cord-023095-4dannjjm 5043 10 in in IN cord-023095-4dannjjm 5043 11 kidney kidney NN cord-023095-4dannjjm 5043 12 , , , cord-023095-4dannjjm 5043 13 liver liver NN cord-023095-4dannjjm 5043 14 , , , cord-023095-4dannjjm 5043 15 and and CC cord-023095-4dannjjm 5043 16 digestive digestive JJ cord-023095-4dannjjm 5043 17 disease disease NN cord-023095-4dannjjm 5043 18 groups group NNS cord-023095-4dannjjm 5043 19 but but CC cord-023095-4dannjjm 5043 20 at at IN cord-023095-4dannjjm 5043 21 p p NN cord-023095-4dannjjm 5043 22 o o NN cord-023095-4dannjjm 5043 23 0.01 0.01 CD cord-023095-4dannjjm 5043 24 . . . cord-023095-4dannjjm 5044 1 Sample sample NN cord-023095-4dannjjm 5044 2 sizes size NNS cord-023095-4dannjjm 5044 3 of of IN cord-023095-4dannjjm 5044 4 the the DT cord-023095-4dannjjm 5044 5 feline feline JJ cord-023095-4dannjjm 5044 6 sera sera NNP cord-023095-4dannjjm 5044 7 were be VBD cord-023095-4dannjjm 5044 8 considerably considerably RB cord-023095-4dannjjm 5044 9 smaller small JJR cord-023095-4dannjjm 5044 10 ( ( -LRB- cord-023095-4dannjjm 5044 11 range range NN cord-023095-4dannjjm 5044 12 of of IN cord-023095-4dannjjm 5044 13 4 4 CD cord-023095-4dannjjm 5044 14 - - SYM cord-023095-4dannjjm 5044 15 13 13 CD cord-023095-4dannjjm 5044 16 per per IN cord-023095-4dannjjm 5044 17 group group NN cord-023095-4dannjjm 5044 18 ) ) -RRB- cord-023095-4dannjjm 5044 19 . . . cord-023095-4dannjjm 5045 1 A a DT cord-023095-4dannjjm 5045 2 limitation limitation NN cord-023095-4dannjjm 5045 3 of of IN cord-023095-4dannjjm 5045 4 this this DT cord-023095-4dannjjm 5045 5 analysis analysis NN cord-023095-4dannjjm 5045 6 is be VBZ cord-023095-4dannjjm 5045 7 that that DT cord-023095-4dannjjm 5045 8 variability variability NN cord-023095-4dannjjm 5045 9 of of IN cord-023095-4dannjjm 5045 10 normal normal JJ cord-023095-4dannjjm 5045 11 data datum NNS cord-023095-4dannjjm 5045 12 may may MD cord-023095-4dannjjm 5045 13 exist exist VB cord-023095-4dannjjm 5045 14 depending depend VBG cord-023095-4dannjjm 5045 15 on on IN cord-023095-4dannjjm 5045 16 diet diet NN cord-023095-4dannjjm 5045 17 fed fed NNP cord-023095-4dannjjm 5045 18 making make VBG cord-023095-4dannjjm 5045 19 comparisons comparison NNS cord-023095-4dannjjm 5045 20 less less RBR cord-023095-4dannjjm 5045 21 reliable reliable JJ cord-023095-4dannjjm 5045 22 However however RB cord-023095-4dannjjm 5045 23 , , , cord-023095-4dannjjm 5045 24 these these DT cord-023095-4dannjjm 5045 25 preliminary preliminary JJ cord-023095-4dannjjm 5045 26 data datum NNS cord-023095-4dannjjm 5045 27 suggest suggest VBP cord-023095-4dannjjm 5045 28 that that IN cord-023095-4dannjjm 5045 29 metabolic metabolic JJ cord-023095-4dannjjm 5045 30 diseases disease NNS cord-023095-4dannjjm 5045 31 of of IN cord-023095-4dannjjm 5045 32 dogs dog NNS cord-023095-4dannjjm 5045 33 may may MD cord-023095-4dannjjm 5045 34 depress depress VB cord-023095-4dannjjm 5045 35 plasma plasma NN cord-023095-4dannjjm 5045 36 arachidonic arachidonic NN cord-023095-4dannjjm 5045 37 acid acid NN cord-023095-4dannjjm 5045 38 independent independent JJ cord-023095-4dannjjm 5045 39 of of IN cord-023095-4dannjjm 5045 40 diet diet NN cord-023095-4dannjjm 5045 41 fed fed NNP cord-023095-4dannjjm 5045 42 suggesting suggest VBG cord-023095-4dannjjm 5045 43 either either CC cord-023095-4dannjjm 5045 44 reduced reduce VBN cord-023095-4dannjjm 5045 45 conversion conversion NN cord-023095-4dannjjm 5045 46 from from IN cord-023095-4dannjjm 5045 47 linoleic linoleic JJ cord-023095-4dannjjm 5045 48 acid acid NN cord-023095-4dannjjm 5045 49 or or CC cord-023095-4dannjjm 5045 50 increased increase VBN cord-023095-4dannjjm 5045 51 utilization utilization NN cord-023095-4dannjjm 5045 52 of of IN cord-023095-4dannjjm 5045 53 arachidonate arachidonate NN cord-023095-4dannjjm 5045 54 for for IN cord-023095-4dannjjm 5045 55 eicosanoid eicosanoid JJ cord-023095-4dannjjm 5045 56 production production NN cord-023095-4dannjjm 5045 57 during during IN cord-023095-4dannjjm 5045 58 times time NNS cord-023095-4dannjjm 5045 59 of of IN cord-023095-4dannjjm 5045 60 metabolic metabolic JJ cord-023095-4dannjjm 5045 61 stress stress NN cord-023095-4dannjjm 5045 62 . . . cord-023095-4dannjjm 5046 1 Conversely conversely RB cord-023095-4dannjjm 5046 2 , , , cord-023095-4dannjjm 5046 3 in in IN cord-023095-4dannjjm 5046 4 cats cat NNS cord-023095-4dannjjm 5046 5 , , , cord-023095-4dannjjm 5046 6 increases increase NNS cord-023095-4dannjjm 5046 7 in in IN cord-023095-4dannjjm 5046 8 arachidonic arachidonic JJ cord-023095-4dannjjm 5046 9 acid acid NN cord-023095-4dannjjm 5046 10 may may MD cord-023095-4dannjjm 5046 11 be be VB cord-023095-4dannjjm 5046 12 associated associate VBN cord-023095-4dannjjm 5046 13 with with IN cord-023095-4dannjjm 5046 14 diet diet NN cord-023095-4dannjjm 5046 15 arachidonate arachidonate NN cord-023095-4dannjjm 5046 16 or or CC cord-023095-4dannjjm 5046 17 other other JJ cord-023095-4dannjjm 5046 18 mechanisms mechanism NNS cord-023095-4dannjjm 5046 19 . . . cord-023095-4dannjjm 5047 1 Additional additional JJ cord-023095-4dannjjm 5047 2 studies study NNS cord-023095-4dannjjm 5047 3 to to TO cord-023095-4dannjjm 5047 4 verify verify VB cord-023095-4dannjjm 5047 5 these these DT cord-023095-4dannjjm 5047 6 findings finding NNS cord-023095-4dannjjm 5047 7 are be VBP cord-023095-4dannjjm 5047 8 warranted warrant VBN cord-023095-4dannjjm 5047 9 . . . cord-023095-4dannjjm 5048 1 The the DT cord-023095-4dannjjm 5048 2 objective objective NN cord-023095-4dannjjm 5048 3 of of IN cord-023095-4dannjjm 5048 4 this this DT cord-023095-4dannjjm 5048 5 study study NN cord-023095-4dannjjm 5048 6 was be VBD cord-023095-4dannjjm 5048 7 to to TO cord-023095-4dannjjm 5048 8 determine determine VB cord-023095-4dannjjm 5048 9 whether whether IN cord-023095-4dannjjm 5048 10 or or CC cord-023095-4dannjjm 5048 11 not not RB cord-023095-4dannjjm 5048 12 Lalanyl Lalanyl NNP cord-023095-4dannjjm 5048 13 - - HYPH cord-023095-4dannjjm 5048 14 L l NN cord-023095-4dannjjm 5048 15 - - HYPH cord-023095-4dannjjm 5048 16 glutamine glutamine NN cord-023095-4dannjjm 5048 17 ( ( -LRB- cord-023095-4dannjjm 5048 18 Ala Ala NNP cord-023095-4dannjjm 5048 19 - - HYPH cord-023095-4dannjjm 5048 20 Gln Gln NNP cord-023095-4dannjjm 5048 21 ) ) -RRB- cord-023095-4dannjjm 5048 22 supplementation supplementation NN cord-023095-4dannjjm 5048 23 in in IN cord-023095-4dannjjm 5048 24 dogs dog NNS cord-023095-4dannjjm 5048 25 with with IN cord-023095-4dannjjm 5048 26 parvoviral parvoviral JJ cord-023095-4dannjjm 5048 27 enteritis enteritis NN cord-023095-4dannjjm 5048 28 improves improve VBZ cord-023095-4dannjjm 5048 29 the the DT cord-023095-4dannjjm 5048 30 survival survival NN cord-023095-4dannjjm 5048 31 rate rate NN cord-023095-4dannjjm 5048 32 and and CC cord-023095-4dannjjm 5048 33 ameliorates ameliorate VBZ cord-023095-4dannjjm 5048 34 clinical clinical JJ cord-023095-4dannjjm 5048 35 signs sign NNS cord-023095-4dannjjm 5048 36 without without IN cord-023095-4dannjjm 5048 37 side side NN cord-023095-4dannjjm 5048 38 effects effect NNS cord-023095-4dannjjm 5048 39 . . . cord-023095-4dannjjm 5049 1 This this DT cord-023095-4dannjjm 5049 2 randomized randomized JJ cord-023095-4dannjjm 5049 3 , , , cord-023095-4dannjjm 5049 4 double double JJ cord-023095-4dannjjm 5049 5 - - HYPH cord-023095-4dannjjm 5049 6 blinded blinded JJ cord-023095-4dannjjm 5049 7 , , , cord-023095-4dannjjm 5049 8 placebo placebo NN cord-023095-4dannjjm 5049 9 - - HYPH cord-023095-4dannjjm 5049 10 controlled control VBN cord-023095-4dannjjm 5049 11 clinical clinical JJ cord-023095-4dannjjm 5049 12 trial trial NN cord-023095-4dannjjm 5049 13 included include VBD cord-023095-4dannjjm 5049 14 39 39 CD cord-023095-4dannjjm 5049 15 client client NN cord-023095-4dannjjm 5049 16 - - HYPH cord-023095-4dannjjm 5049 17 owned own VBN cord-023095-4dannjjm 5049 18 dogs dog NNS cord-023095-4dannjjm 5049 19 . . . cord-023095-4dannjjm 5050 1 The the DT cord-023095-4dannjjm 5050 2 dogs dog NNS cord-023095-4dannjjm 5050 3 were be VBD cord-023095-4dannjjm 5050 4 randomly randomly RB cord-023095-4dannjjm 5050 5 assigned assign VBN cord-023095-4dannjjm 5050 6 into into IN cord-023095-4dannjjm 5050 7 two two CD cord-023095-4dannjjm 5050 8 groups group NNS cord-023095-4dannjjm 5050 9 and and CC cord-023095-4dannjjm 5050 10 administered administer VBN cord-023095-4dannjjm 5050 11 Ala Ala NNP cord-023095-4dannjjm 5050 12 - - HYPH cord-023095-4dannjjm 5050 13 Gln Gln NNP cord-023095-4dannjjm 5050 14 solution solution NN cord-023095-4dannjjm 5050 15 ( ( -LRB- cord-023095-4dannjjm 5050 16 Dipeptiven Dipeptiven NNP cord-023095-4dannjjm 5050 17 ; ; : cord-023095-4dannjjm 5050 18 0.4 0.4 CD cord-023095-4dannjjm 5050 19 g g NN cord-023095-4dannjjm 5050 20 / / SYM cord-023095-4dannjjm 5050 21 kg kg NNP cord-023095-4dannjjm 5050 22 ) ) -RRB- cord-023095-4dannjjm 5050 23 or or CC cord-023095-4dannjjm 5050 24 an an DT cord-023095-4dannjjm 5050 25 equivalent equivalent JJ cord-023095-4dannjjm 5050 26 volume volume NN cord-023095-4dannjjm 5050 27 of of IN cord-023095-4dannjjm 5050 28 placebo placebo NN cord-023095-4dannjjm 5050 29 orally orally RB cord-023095-4dannjjm 5050 30 twice twice PDT cord-023095-4dannjjm 5050 31 a a DT cord-023095-4dannjjm 5050 32 day day NN cord-023095-4dannjjm 5050 33 . . . cord-023095-4dannjjm 5051 1 All all DT cord-023095-4dannjjm 5051 2 of of IN cord-023095-4dannjjm 5051 3 the the DT cord-023095-4dannjjm 5051 4 dogs dog NNS cord-023095-4dannjjm 5051 5 ( ( -LRB- cord-023095-4dannjjm 5051 6 Ala Ala NNP cord-023095-4dannjjm 5051 7 - - HYPH cord-023095-4dannjjm 5051 8 Gln Gln NNP cord-023095-4dannjjm 5051 9 group group NN cord-023095-4dannjjm 5051 10 [ [ -LRB- cord-023095-4dannjjm 5051 11 n n NN cord-023095-4dannjjm 5051 12 5 5 CD cord-023095-4dannjjm 5051 13 20 20 CD cord-023095-4dannjjm 5051 14 ] ] -RRB- cord-023095-4dannjjm 5051 15 and and CC cord-023095-4dannjjm 5051 16 placebo placebo NN cord-023095-4dannjjm 5051 17 group group NN cord-023095-4dannjjm 5051 18 [ [ -LRB- cord-023095-4dannjjm 5051 19 n n NN cord-023095-4dannjjm 5051 20 5 5 CD cord-023095-4dannjjm 5051 21 19 19 CD cord-023095-4dannjjm 5051 22 ] ] -RRB- cord-023095-4dannjjm 5051 23 ) ) -RRB- cord-023095-4dannjjm 5051 24 received receive VBD cord-023095-4dannjjm 5051 25 standard standard JJ cord-023095-4dannjjm 5051 26 treatment treatment NN cord-023095-4dannjjm 5051 27 while while IN cord-023095-4dannjjm 5051 28 hospitalized hospitalize VBN cord-023095-4dannjjm 5051 29 and and CC cord-023095-4dannjjm 5051 30 were be VBD cord-023095-4dannjjm 5051 31 monitored monitor VBN cord-023095-4dannjjm 5051 32 daily daily RB cord-023095-4dannjjm 5051 33 according accord VBG cord-023095-4dannjjm 5051 34 to to IN cord-023095-4dannjjm 5051 35 a a DT cord-023095-4dannjjm 5051 36 clinical clinical JJ cord-023095-4dannjjm 5051 37 scoring scoring NN cord-023095-4dannjjm 5051 38 system system NN cord-023095-4dannjjm 5051 39 and and CC cord-023095-4dannjjm 5051 40 diagnostic diagnostic JJ cord-023095-4dannjjm 5051 41 evaluation evaluation NN cord-023095-4dannjjm 5051 42 for for IN cord-023095-4dannjjm 5051 43 11 11 CD cord-023095-4dannjjm 5051 44 days day NNS cord-023095-4dannjjm 5051 45 . . . cord-023095-4dannjjm 5052 1 Among among IN cord-023095-4dannjjm 5052 2 the the DT cord-023095-4dannjjm 5052 3 39 39 CD cord-023095-4dannjjm 5052 4 dogs dog NNS cord-023095-4dannjjm 5052 5 , , , cord-023095-4dannjjm 5052 6 17 17 CD cord-023095-4dannjjm 5052 7 ( ( -LRB- cord-023095-4dannjjm 5052 8 Ala Ala NNP cord-023095-4dannjjm 5052 9 - - HYPH cord-023095-4dannjjm 5052 10 Gln Gln NNP cord-023095-4dannjjm 5052 11 - - HYPH cord-023095-4dannjjm 5052 12 treated treat VBN cord-023095-4dannjjm 5052 13 group group NN cord-023095-4dannjjm 5052 14 [ [ -LRB- cord-023095-4dannjjm 5052 15 n n NN cord-023095-4dannjjm 5052 16 5 5 CD cord-023095-4dannjjm 5052 17 8 8 CD cord-023095-4dannjjm 5052 18 ] ] -RRB- cord-023095-4dannjjm 5052 19 and and CC cord-023095-4dannjjm 5052 20 placebo placebo NN cord-023095-4dannjjm 5052 21 group group NN cord-023095-4dannjjm 5052 22 [ [ -LRB- cord-023095-4dannjjm 5052 23 n n NN cord-023095-4dannjjm 5052 24 5 5 CD cord-023095-4dannjjm 5052 25 9 9 CD cord-023095-4dannjjm 5052 26 ] ] -RRB- cord-023095-4dannjjm 5052 27 ) ) -RRB- cord-023095-4dannjjm 5052 28 were be VBD cord-023095-4dannjjm 5052 29 vaccinated vaccinate VBN cord-023095-4dannjjm 5052 30 and and CC cord-023095-4dannjjm 5052 31 22 22 CD cord-023095-4dannjjm 5053 1 ( ( -LRB- cord-023095-4dannjjm 5053 2 Ala Ala NNP cord-023095-4dannjjm 5053 3 - - HYPH cord-023095-4dannjjm 5053 4 Gln Gln NNP cord-023095-4dannjjm 5053 5 - - HYPH cord-023095-4dannjjm 5053 6 treated treat VBN cord-023095-4dannjjm 5053 7 group group NN cord-023095-4dannjjm 5053 8 [ [ -LRB- cord-023095-4dannjjm 5053 9 n n NN cord-023095-4dannjjm 5053 10 5 5 CD cord-023095-4dannjjm 5053 11 12 12 CD cord-023095-4dannjjm 5053 12 ] ] -RRB- cord-023095-4dannjjm 5053 13 and and CC cord-023095-4dannjjm 5053 14 placebo placebo NN cord-023095-4dannjjm 5053 15 group group NN cord-023095-4dannjjm 5053 16 [ [ -LRB- cord-023095-4dannjjm 5053 17 n n NN cord-023095-4dannjjm 5053 18 5 5 CD cord-023095-4dannjjm 5053 19 10 10 CD cord-023095-4dannjjm 5053 20 ] ] -RRB- cord-023095-4dannjjm 5053 21 ) ) -RRB- cord-023095-4dannjjm 5053 22 were be VBD cord-023095-4dannjjm 5053 23 not not RB cord-023095-4dannjjm 5053 24 vaccinated vaccinate VBN cord-023095-4dannjjm 5053 25 . . . cord-023095-4dannjjm 5054 1 The the DT cord-023095-4dannjjm 5054 2 population population NN cord-023095-4dannjjm 5054 3 consisted consist VBD cord-023095-4dannjjm 5054 4 of of IN cord-023095-4dannjjm 5054 5 29 29 CD cord-023095-4dannjjm 5054 6 purebreds purebred NNS cord-023095-4dannjjm 5054 7 and and CC cord-023095-4dannjjm 5054 8 10 10 CD cord-023095-4dannjjm 5054 9 mixed mixed JJ cord-023095-4dannjjm 5054 10 breed breed NN cord-023095-4dannjjm 5054 11 dogs dog NNS cord-023095-4dannjjm 5054 12 , , , cord-023095-4dannjjm 5054 13 with with IN cord-023095-4dannjjm 5054 14 a a DT cord-023095-4dannjjm 5054 15 mean mean JJ cord-023095-4dannjjm 5054 16 age age NN cord-023095-4dannjjm 5054 17 of of IN cord-023095-4dannjjm 5054 18 12.2 12.2 CD cord-023095-4dannjjm 5054 19 AE AE NNP cord-023095-4dannjjm 5054 20 2.2 2.2 CD cord-023095-4dannjjm 5054 21 weeks week NNS cord-023095-4dannjjm 5054 22 . . . cord-023095-4dannjjm 5055 1 The the DT cord-023095-4dannjjm 5055 2 survival survival NN cord-023095-4dannjjm 5055 3 data datum NNS cord-023095-4dannjjm 5055 4 were be VBD cord-023095-4dannjjm 5055 5 compared compare VBN cord-023095-4dannjjm 5055 6 statistically statistically RB cord-023095-4dannjjm 5055 7 by by IN cord-023095-4dannjjm 5055 8 means mean NNS cord-023095-4dannjjm 5055 9 of of IN cord-023095-4dannjjm 5055 10 a a DT cord-023095-4dannjjm 5055 11 log log NN cord-023095-4dannjjm 5055 12 - - HYPH cord-023095-4dannjjm 5055 13 rank rank NN cord-023095-4dannjjm 5055 14 test test NN cord-023095-4dannjjm 5055 15 for for IN cord-023095-4dannjjm 5055 16 the the DT cord-023095-4dannjjm 5055 17 Kaplan Kaplan NNP cord-023095-4dannjjm 5055 18 - - HYPH cord-023095-4dannjjm 5055 19 Meier Meier NNP cord-023095-4dannjjm 5055 20 survival survival NN cord-023095-4dannjjm 5055 21 curves curve NNS cord-023095-4dannjjm 5055 22 . . . cord-023095-4dannjjm 5056 1 The the DT cord-023095-4dannjjm 5056 2 clinical clinical JJ cord-023095-4dannjjm 5056 3 scores score NNS cord-023095-4dannjjm 5056 4 of of IN cord-023095-4dannjjm 5056 5 Ala Ala NNP cord-023095-4dannjjm 5056 6 - - HYPH cord-023095-4dannjjm 5056 7 Gln Gln NNP cord-023095-4dannjjm 5056 8 - - HYPH cord-023095-4dannjjm 5056 9 treated treat VBN cord-023095-4dannjjm 5056 10 dogs dog NNS cord-023095-4dannjjm 5056 11 improved improve VBD cord-023095-4dannjjm 5056 12 significantly significantly RB cord-023095-4dannjjm 5056 13 relative relative JJ cord-023095-4dannjjm 5056 14 to to IN cord-023095-4dannjjm 5056 15 the the DT cord-023095-4dannjjm 5056 16 placebo placebo NN cord-023095-4dannjjm 5056 17 group group NN cord-023095-4dannjjm 5056 18 . . . cord-023095-4dannjjm 5057 1 There there EX cord-023095-4dannjjm 5057 2 was be VBD cord-023095-4dannjjm 5057 3 a a DT cord-023095-4dannjjm 5057 4 significant significant JJ cord-023095-4dannjjm 5057 5 difference difference NN cord-023095-4dannjjm 5057 6 between between IN cord-023095-4dannjjm 5057 7 the the DT cord-023095-4dannjjm 5057 8 two two CD cord-023095-4dannjjm 5057 9 groups group NNS cord-023095-4dannjjm 5057 10 in in IN cord-023095-4dannjjm 5057 11 the the DT cord-023095-4dannjjm 5057 12 survival survival NN cord-023095-4dannjjm 5057 13 distribution distribution NN cord-023095-4dannjjm 5057 14 ( ( -LRB- cord-023095-4dannjjm 5057 15 P p NN cord-023095-4dannjjm 5057 16 5 5 CD cord-023095-4dannjjm 5057 17 0.038 0.038 CD cord-023095-4dannjjm 5057 18 ) ) -RRB- cord-023095-4dannjjm 5057 19 ; ; : cord-023095-4dannjjm 5057 20 specifically specifically RB cord-023095-4dannjjm 5057 21 , , , cord-023095-4dannjjm 5057 22 3 3 CD cord-023095-4dannjjm 5057 23 of of IN cord-023095-4dannjjm 5057 24 the the DT cord-023095-4dannjjm 5057 25 Ala Ala NNP cord-023095-4dannjjm 5057 26 - - HYPH cord-023095-4dannjjm 5057 27 Gln Gln NNP cord-023095-4dannjjm 5057 28 - - HYPH cord-023095-4dannjjm 5057 29 treated treat VBN cord-023095-4dannjjm 5057 30 dogs dog NNS cord-023095-4dannjjm 5057 31 ( ( -LRB- cord-023095-4dannjjm 5057 32 15.0 15.0 CD cord-023095-4dannjjm 5057 33 % % NN cord-023095-4dannjjm 5057 34 ) ) -RRB- cord-023095-4dannjjm 5057 35 died die VBD cord-023095-4dannjjm 5057 36 , , , cord-023095-4dannjjm 5057 37 whereas whereas IN cord-023095-4dannjjm 5057 38 8 8 CD cord-023095-4dannjjm 5057 39 of of IN cord-023095-4dannjjm 5057 40 the the DT cord-023095-4dannjjm 5057 41 dogs dog NNS cord-023095-4dannjjm 5057 42 in in IN cord-023095-4dannjjm 5057 43 the the DT cord-023095-4dannjjm 5057 44 placebo placebo NN cord-023095-4dannjjm 5057 45 group group NN cord-023095-4dannjjm 5057 46 ( ( -LRB- cord-023095-4dannjjm 5057 47 42.1 42.1 CD cord-023095-4dannjjm 5057 48 % % NN cord-023095-4dannjjm 5057 49 ) ) -RRB- cord-023095-4dannjjm 5057 50 died die VBD cord-023095-4dannjjm 5057 51 . . . cord-023095-4dannjjm 5058 1 No no DT cord-023095-4dannjjm 5058 2 side side NN cord-023095-4dannjjm 5058 3 effects effect NNS cord-023095-4dannjjm 5058 4 were be VBD cord-023095-4dannjjm 5058 5 associated associate VBN cord-023095-4dannjjm 5058 6 with with IN cord-023095-4dannjjm 5058 7 the the DT cord-023095-4dannjjm 5058 8 administration administration NN cord-023095-4dannjjm 5058 9 of of IN cord-023095-4dannjjm 5058 10 Ala Ala NNP cord-023095-4dannjjm 5058 11 - - HYPH cord-023095-4dannjjm 5058 12 Gln Gln NNP cord-023095-4dannjjm 5058 13 . . . cord-023095-4dannjjm 5059 1 These these DT cord-023095-4dannjjm 5059 2 results result NNS cord-023095-4dannjjm 5059 3 suggest suggest VBP cord-023095-4dannjjm 5059 4 that that IN cord-023095-4dannjjm 5059 5 the the DT cord-023095-4dannjjm 5059 6 oral oral JJ cord-023095-4dannjjm 5059 7 administration administration NN cord-023095-4dannjjm 5059 8 of of IN cord-023095-4dannjjm 5059 9 Ala Ala NNP cord-023095-4dannjjm 5059 10 - - HYPH cord-023095-4dannjjm 5059 11 Gln Gln NNP cord-023095-4dannjjm 5059 12 is be VBZ cord-023095-4dannjjm 5059 13 effective effective JJ cord-023095-4dannjjm 5059 14 in in IN cord-023095-4dannjjm 5059 15 improving improve VBG cord-023095-4dannjjm 5059 16 clinical clinical JJ cord-023095-4dannjjm 5059 17 signs sign NNS cord-023095-4dannjjm 5059 18 and and CC cord-023095-4dannjjm 5059 19 survival survival NN cord-023095-4dannjjm 5059 20 rate rate NN cord-023095-4dannjjm 5059 21 in in IN cord-023095-4dannjjm 5059 22 dogs dog NNS cord-023095-4dannjjm 5059 23 with with IN cord-023095-4dannjjm 5059 24 parvoviral parvoviral JJ cord-023095-4dannjjm 5059 25 enteritis enteritis NN cord-023095-4dannjjm 5059 26 . . . cord-023095-4dannjjm 5060 1 Bleeding bleed VBG cord-023095-4dannjjm 5060 2 disorders disorder NNS cord-023095-4dannjjm 5060 3 , , , cord-023095-4dannjjm 5060 4 thrombocytopenia thrombocytopenia NN cord-023095-4dannjjm 5060 5 and and CC cord-023095-4dannjjm 5060 6 alterations alteration NNS cord-023095-4dannjjm 5060 7 in in IN cord-023095-4dannjjm 5060 8 platelet platelet NN cord-023095-4dannjjm 5060 9 function function NN cord-023095-4dannjjm 5060 10 have have VBP cord-023095-4dannjjm 5060 11 been be VBN cord-023095-4dannjjm 5060 12 documented document VBN cord-023095-4dannjjm 5060 13 in in IN cord-023095-4dannjjm 5060 14 humans human NNS cord-023095-4dannjjm 5060 15 receiving receive VBG cord-023095-4dannjjm 5060 16 lipid lipid NN cord-023095-4dannjjm 5060 17 - - HYPH cord-023095-4dannjjm 5060 18 containing contain VBG cord-023095-4dannjjm 5060 19 parenteral parenteral JJ cord-023095-4dannjjm 5060 20 nutrition nutrition NN cord-023095-4dannjjm 5060 21 formulations formulation NNS cord-023095-4dannjjm 5060 22 . . . cord-023095-4dannjjm 5061 1 Despite despite IN cord-023095-4dannjjm 5061 2 a a DT cord-023095-4dannjjm 5061 3 lack lack NN cord-023095-4dannjjm 5061 4 of of IN cord-023095-4dannjjm 5061 5 evidence evidence NN cord-023095-4dannjjm 5061 6 in in IN cord-023095-4dannjjm 5061 7 the the DT cord-023095-4dannjjm 5061 8 veterinary veterinary JJ cord-023095-4dannjjm 5061 9 literature literature NN cord-023095-4dannjjm 5061 10 , , , cord-023095-4dannjjm 5061 11 it -PRON- PRP cord-023095-4dannjjm 5061 12 is be VBZ cord-023095-4dannjjm 5061 13 believed believe VBN cord-023095-4dannjjm 5061 14 that that IN cord-023095-4dannjjm 5061 15 parenteral parenteral JJ cord-023095-4dannjjm 5061 16 lipids lipid NNS cord-023095-4dannjjm 5061 17 are be VBP cord-023095-4dannjjm 5061 18 contraindicated contraindicated JJ cord-023095-4dannjjm 5061 19 in in IN cord-023095-4dannjjm 5061 20 critical critical JJ cord-023095-4dannjjm 5061 21 illness illness NN cord-023095-4dannjjm 5061 22 when when WRB cord-023095-4dannjjm 5061 23 the the DT cord-023095-4dannjjm 5061 24 development development NN cord-023095-4dannjjm 5061 25 of of IN cord-023095-4dannjjm 5061 26 bleeding bleed VBG cord-023095-4dannjjm 5061 27 disorders disorder NNS cord-023095-4dannjjm 5061 28 is be VBZ cord-023095-4dannjjm 5061 29 likely likely JJ cord-023095-4dannjjm 5061 30 . . . cord-023095-4dannjjm 5062 1 The the DT cord-023095-4dannjjm 5062 2 objective objective NN cord-023095-4dannjjm 5062 3 of of IN cord-023095-4dannjjm 5062 4 this this DT cord-023095-4dannjjm 5062 5 study study NN cord-023095-4dannjjm 5062 6 was be VBD cord-023095-4dannjjm 5062 7 to to TO cord-023095-4dannjjm 5062 8 determine determine VB cord-023095-4dannjjm 5062 9 if if IN cord-023095-4dannjjm 5062 10 there there EX cord-023095-4dannjjm 5062 11 is be VBZ cord-023095-4dannjjm 5062 12 an an DT cord-023095-4dannjjm 5062 13 in in FW cord-023095-4dannjjm 5062 14 vitro vitro FW cord-023095-4dannjjm 5062 15 effect effect NN cord-023095-4dannjjm 5062 16 on on IN cord-023095-4dannjjm 5062 17 platelet platelet NN cord-023095-4dannjjm 5062 18 function function NN cord-023095-4dannjjm 5062 19 and and CC cord-023095-4dannjjm 5062 20 thromboelastography thromboelastography NNP cord-023095-4dannjjm 5062 21 ( ( -LRB- cord-023095-4dannjjm 5062 22 TEG TEG NNP cord-023095-4dannjjm 5062 23 ) ) -RRB- cord-023095-4dannjjm 5062 24 in in IN cord-023095-4dannjjm 5062 25 normal normal JJ cord-023095-4dannjjm 5062 26 dogs dog NNS cord-023095-4dannjjm 5062 27 with with IN cord-023095-4dannjjm 5062 28 varying vary VBG cord-023095-4dannjjm 5062 29 concentrations concentration NNS cord-023095-4dannjjm 5062 30 of of IN cord-023095-4dannjjm 5062 31 a a DT cord-023095-4dannjjm 5062 32 20 20 CD cord-023095-4dannjjm 5062 33 % % NN cord-023095-4dannjjm 5062 34 soybean soybean NN cord-023095-4dannjjm 5062 35 oil oil NN cord-023095-4dannjjm 5062 36 emulsion emulsion NN cord-023095-4dannjjm 5062 37 ( ( -LRB- cord-023095-4dannjjm 5062 38 Intralipid Intralipid NNP cord-023095-4dannjjm 5062 39 s s POS cord-023095-4dannjjm 5062 40 ) ) -RRB- cord-023095-4dannjjm 5062 41 . . . cord-023095-4dannjjm 5063 1 Twelve twelve CD cord-023095-4dannjjm 5063 2 clinically clinically RB cord-023095-4dannjjm 5063 3 healthy healthy JJ cord-023095-4dannjjm 5063 4 dogs dog NNS cord-023095-4dannjjm 5063 5 were be VBD cord-023095-4dannjjm 5063 6 used use VBN cord-023095-4dannjjm 5063 7 for for IN cord-023095-4dannjjm 5063 8 this this DT cord-023095-4dannjjm 5063 9 study study NN cord-023095-4dannjjm 5063 10 . . . cord-023095-4dannjjm 5064 1 Whole whole JJ cord-023095-4dannjjm 5064 2 blood blood NN cord-023095-4dannjjm 5064 3 platelet platelet NN cord-023095-4dannjjm 5064 4 aggregation aggregation NN cord-023095-4dannjjm 5064 5 , , , cord-023095-4dannjjm 5064 6 using use VBG cord-023095-4dannjjm 5064 7 ADP ADP NNP cord-023095-4dannjjm 5064 8 and and CC cord-023095-4dannjjm 5064 9 collagen collagen NN cord-023095-4dannjjm 5064 10 agonists agonist NNS cord-023095-4dannjjm 5064 11 , , , cord-023095-4dannjjm 5064 12 was be VBD cord-023095-4dannjjm 5064 13 measured measure VBN cord-023095-4dannjjm 5064 14 using use VBG cord-023095-4dannjjm 5064 15 multiple multiple JJ cord-023095-4dannjjm 5064 16 electrode electrode NN cord-023095-4dannjjm 5064 17 aggregometry aggregometry NN cord-023095-4dannjjm 5064 18 in in IN cord-023095-4dannjjm 5064 19 hirudinated hirudinate VBN cord-023095-4dannjjm 5064 20 blood blood NN cord-023095-4dannjjm 5064 21 with with IN cord-023095-4dannjjm 5064 22 final final JJ cord-023095-4dannjjm 5064 23 lipid lipid NN cord-023095-4dannjjm 5064 24 concentrations concentration NNS cord-023095-4dannjjm 5064 25 of of IN cord-023095-4dannjjm 5064 26 0 0 CD cord-023095-4dannjjm 5064 27 , , , cord-023095-4dannjjm 5064 28 1 1 CD cord-023095-4dannjjm 5064 29 , , , cord-023095-4dannjjm 5064 30 10 10 CD cord-023095-4dannjjm 5064 31 , , , cord-023095-4dannjjm 5064 32 and and CC cord-023095-4dannjjm 5064 33 30 30 CD cord-023095-4dannjjm 5064 34 mg mg NN cord-023095-4dannjjm 5064 35 / / SYM cord-023095-4dannjjm 5064 36 ml ml NN cord-023095-4dannjjm 5064 37 . . . cord-023095-4dannjjm 5065 1 The the DT cord-023095-4dannjjm 5065 2 TEG TEG NNP cord-023095-4dannjjm 5065 3 parameters parameter NNS cord-023095-4dannjjm 5065 4 R r NN cord-023095-4dannjjm 5065 5 , , , cord-023095-4dannjjm 5065 6 K K NNP cord-023095-4dannjjm 5065 7 , , , cord-023095-4dannjjm 5065 8 a a DT cord-023095-4dannjjm 5065 9 - - HYPH cord-023095-4dannjjm 5065 10 angle angle NN cord-023095-4dannjjm 5065 11 , , , cord-023095-4dannjjm 5065 12 and and CC cord-023095-4dannjjm 5065 13 maximum maximum JJ cord-023095-4dannjjm 5065 14 amplitude amplitude NN cord-023095-4dannjjm 5065 15 ( ( -LRB- cord-023095-4dannjjm 5065 16 MA MA NNP cord-023095-4dannjjm 5065 17 ) ) -RRB- cord-023095-4dannjjm 5065 18 were be VBD cord-023095-4dannjjm 5065 19 evaluated evaluate VBN cord-023095-4dannjjm 5065 20 from from IN cord-023095-4dannjjm 5065 21 citrated citrate VBN cord-023095-4dannjjm 5065 22 whole whole JJ cord-023095-4dannjjm 5065 23 blood blood NN cord-023095-4dannjjm 5065 24 with with IN cord-023095-4dannjjm 5065 25 equivalent equivalent JJ cord-023095-4dannjjm 5065 26 final final JJ cord-023095-4dannjjm 5065 27 lipid lipid NN cord-023095-4dannjjm 5065 28 concentrations concentration NNS cord-023095-4dannjjm 5065 29 as as IN cord-023095-4dannjjm 5065 30 platelet platelet NN cord-023095-4dannjjm 5065 31 aggregation aggregation NN cord-023095-4dannjjm 5065 32 . . . cord-023095-4dannjjm 5066 1 There there EX cord-023095-4dannjjm 5066 2 was be VBD cord-023095-4dannjjm 5066 3 no no DT cord-023095-4dannjjm 5066 4 significant significant JJ cord-023095-4dannjjm 5066 5 difference difference NN cord-023095-4dannjjm 5066 6 between between IN cord-023095-4dannjjm 5066 7 groups group NNS cord-023095-4dannjjm 5066 8 with with IN cord-023095-4dannjjm 5066 9 collageninduced collageninduced JJ cord-023095-4dannjjm 5066 10 platelet platelet NN cord-023095-4dannjjm 5066 11 aggregation aggregation NN cord-023095-4dannjjm 5066 12 . . . cord-023095-4dannjjm 5067 1 There there EX cord-023095-4dannjjm 5067 2 was be VBD cord-023095-4dannjjm 5067 3 a a DT cord-023095-4dannjjm 5067 4 significant significant JJ cord-023095-4dannjjm 5067 5 increase increase NN cord-023095-4dannjjm 5067 6 in in IN cord-023095-4dannjjm 5067 7 the the DT cord-023095-4dannjjm 5067 8 area area NN cord-023095-4dannjjm 5067 9 under under IN cord-023095-4dannjjm 5067 10 the the DT cord-023095-4dannjjm 5067 11 curve curve NN cord-023095-4dannjjm 5067 12 ( ( -LRB- cord-023095-4dannjjm 5067 13 AUC AUC NNP cord-023095-4dannjjm 5067 14 ) ) -RRB- cord-023095-4dannjjm 5067 15 with with IN cord-023095-4dannjjm 5067 16 ADP ADP NNP cord-023095-4dannjjm 5067 17 - - HYPH cord-023095-4dannjjm 5067 18 induced induce VBN cord-023095-4dannjjm 5067 19 aggregation aggregation NN cord-023095-4dannjjm 5067 20 at at IN cord-023095-4dannjjm 5067 21 a a DT cord-023095-4dannjjm 5067 22 lipid lipid NN cord-023095-4dannjjm 5067 23 concentration concentration NN cord-023095-4dannjjm 5067 24 of of IN cord-023095-4dannjjm 5067 25 30 30 CD cord-023095-4dannjjm 5067 26 mg mg NNP cord-023095-4dannjjm 5067 27 / / SYM cord-023095-4dannjjm 5067 28 ml ml NN cord-023095-4dannjjm 5067 29 ( ( -LRB- cord-023095-4dannjjm 5067 30 p p NN cord-023095-4dannjjm 5067 31 5 5 CD cord-023095-4dannjjm 5067 32 0.027 0.027 CD cord-023095-4dannjjm 5067 33 ) ) -RRB- cord-023095-4dannjjm 5067 34 . . . cord-023095-4dannjjm 5068 1 The the DT cord-023095-4dannjjm 5068 2 MA MA NNP cord-023095-4dannjjm 5068 3 was be VBD cord-023095-4dannjjm 5068 4 significantly significantly RB cord-023095-4dannjjm 5068 5 reduced reduce VBN cord-023095-4dannjjm 5068 6 at at IN cord-023095-4dannjjm 5068 7 both both CC cord-023095-4dannjjm 5068 8 the the DT cord-023095-4dannjjm 5068 9 10 10 CD cord-023095-4dannjjm 5068 10 mg mg NNP cord-023095-4dannjjm 5068 11 / / SYM cord-023095-4dannjjm 5068 12 ml ml NN cord-023095-4dannjjm 5068 13 ( ( -LRB- cord-023095-4dannjjm 5069 1 p p NN cord-023095-4dannjjm 5069 2 o o NN cord-023095-4dannjjm 5069 3 0.001 0.001 CD cord-023095-4dannjjm 5069 4 ) ) -RRB- cord-023095-4dannjjm 5069 5 and and CC cord-023095-4dannjjm 5069 6 30 30 CD cord-023095-4dannjjm 5069 7 mg mg NN cord-023095-4dannjjm 5069 8 / / SYM cord-023095-4dannjjm 5069 9 ml ml NN cord-023095-4dannjjm 5070 1 ( ( -LRB- cord-023095-4dannjjm 5070 2 p p NN cord-023095-4dannjjm 5070 3 o o NN cord-023095-4dannjjm 5070 4 0.001 0.001 CD cord-023095-4dannjjm 5070 5 ) ) -RRB- cord-023095-4dannjjm 5070 6 lipid lipid NN cord-023095-4dannjjm 5070 7 concentration concentration NN cord-023095-4dannjjm 5070 8 . . . cord-023095-4dannjjm 5071 1 There there EX cord-023095-4dannjjm 5071 2 was be VBD cord-023095-4dannjjm 5071 3 no no DT cord-023095-4dannjjm 5071 4 statistical statistical JJ cord-023095-4dannjjm 5071 5 difference difference NN cord-023095-4dannjjm 5071 6 between between IN cord-023095-4dannjjm 5071 7 groups group NNS cord-023095-4dannjjm 5071 8 evaluating evaluate VBG cord-023095-4dannjjm 5071 9 the the DT cord-023095-4dannjjm 5071 10 other other JJ cord-023095-4dannjjm 5071 11 TEG TEG NNP cord-023095-4dannjjm 5071 12 parameters parameter NNS cord-023095-4dannjjm 5071 13 . . . cord-023095-4dannjjm 5072 1 While while IN cord-023095-4dannjjm 5072 2 platelet platelet NN cord-023095-4dannjjm 5072 3 aggregation aggregation NN cord-023095-4dannjjm 5072 4 appeared appear VBD cord-023095-4dannjjm 5072 5 enhanced enhance VBN cord-023095-4dannjjm 5072 6 at at IN cord-023095-4dannjjm 5072 7 the the DT cord-023095-4dannjjm 5072 8 highest high JJS cord-023095-4dannjjm 5072 9 concentration concentration NN cord-023095-4dannjjm 5072 10 evaluated evaluate VBN cord-023095-4dannjjm 5072 11 , , , cord-023095-4dannjjm 5072 12 this this DT cord-023095-4dannjjm 5072 13 concentration concentration NN cord-023095-4dannjjm 5072 14 is be VBZ cord-023095-4dannjjm 5072 15 not not RB cord-023095-4dannjjm 5072 16 clinically clinically RB cord-023095-4dannjjm 5072 17 relevant relevant JJ cord-023095-4dannjjm 5072 18 . . . cord-023095-4dannjjm 5073 1 The the DT cord-023095-4dannjjm 5073 2 reduction reduction NN cord-023095-4dannjjm 5073 3 in in IN cord-023095-4dannjjm 5073 4 MA MA NNP cord-023095-4dannjjm 5073 5 seems seem VBZ cord-023095-4dannjjm 5073 6 discordant discordant JJ cord-023095-4dannjjm 5073 7 but but CC cord-023095-4dannjjm 5073 8 both both CC cord-023095-4dannjjm 5073 9 fibrinogen fibrinogen NN cord-023095-4dannjjm 5073 10 and and CC cord-023095-4dannjjm 5073 11 platelets platelet NNS cord-023095-4dannjjm 5073 12 contribute contribute VBP cord-023095-4dannjjm 5073 13 to to IN cord-023095-4dannjjm 5073 14 the the DT cord-023095-4dannjjm 5073 15 MA MA NNP cord-023095-4dannjjm 5073 16 . . . cord-023095-4dannjjm 5074 1 Therefore therefore RB cord-023095-4dannjjm 5074 2 the the DT cord-023095-4dannjjm 5074 3 higher high JJR cord-023095-4dannjjm 5074 4 lipid lipid NN cord-023095-4dannjjm 5074 5 concentrations concentration NNS cord-023095-4dannjjm 5074 6 may may MD cord-023095-4dannjjm 5074 7 be be VB cord-023095-4dannjjm 5074 8 interfering interfere VBG cord-023095-4dannjjm 5074 9 with with IN cord-023095-4dannjjm 5074 10 fibrinogen fibrinogen NN cord-023095-4dannjjm 5074 11 kinetics kinetic NNS cord-023095-4dannjjm 5074 12 or or CC cord-023095-4dannjjm 5074 13 fibrinogenplatelet fibrinogenplatelet NN cord-023095-4dannjjm 5074 14 interaction interaction NN cord-023095-4dannjjm 5074 15 . . . cord-023095-4dannjjm 5075 1 In in IN cord-023095-4dannjjm 5075 2 vivo vivo NNP cord-023095-4dannjjm 5075 3 studies study NNS cord-023095-4dannjjm 5075 4 are be VBP cord-023095-4dannjjm 5075 5 indicated indicate VBN cord-023095-4dannjjm 5075 6 to to TO cord-023095-4dannjjm 5075 7 determine determine VB cord-023095-4dannjjm 5075 8 if if IN cord-023095-4dannjjm 5075 9 any any DT cord-023095-4dannjjm 5075 10 of of IN cord-023095-4dannjjm 5075 11 these these DT cord-023095-4dannjjm 5075 12 changes change NNS cord-023095-4dannjjm 5075 13 are be VBP cord-023095-4dannjjm 5075 14 clinically clinically RB cord-023095-4dannjjm 5075 15 significant significant JJ cord-023095-4dannjjm 5075 16 . . . cord-023095-4dannjjm 5076 1 Rosiglitazone rosiglitazone NN cord-023095-4dannjjm 5076 2 is be VBZ cord-023095-4dannjjm 5076 3 a a DT cord-023095-4dannjjm 5076 4 peroxisome peroxisome NN cord-023095-4dannjjm 5076 5 proliferator proliferator NN cord-023095-4dannjjm 5076 6 - - HYPH cord-023095-4dannjjm 5076 7 activated activate VBN cord-023095-4dannjjm 5076 8 receptor receptor NN cord-023095-4dannjjm 5076 9 gamma gamma NN cord-023095-4dannjjm 5076 10 ( ( -LRB- cord-023095-4dannjjm 5076 11 PPARg PPARg NNS cord-023095-4dannjjm 5076 12 ) ) -RRB- cord-023095-4dannjjm 5076 13 agonist agonist NN cord-023095-4dannjjm 5076 14 and and CC cord-023095-4dannjjm 5076 15 an an DT cord-023095-4dannjjm 5076 16 FDA FDA NNP cord-023095-4dannjjm 5076 17 - - HYPH cord-023095-4dannjjm 5076 18 approved approve VBN cord-023095-4dannjjm 5076 19 anti anti JJ cord-023095-4dannjjm 5076 20 - - JJ cord-023095-4dannjjm 5076 21 diabetic diabetic JJ cord-023095-4dannjjm 5076 22 agent agent NN cord-023095-4dannjjm 5076 23 in in IN cord-023095-4dannjjm 5076 24 humans human NNS cord-023095-4dannjjm 5076 25 that that WDT cord-023095-4dannjjm 5076 26 has have VBZ cord-023095-4dannjjm 5076 27 been be VBN cord-023095-4dannjjm 5076 28 investigated investigate VBN cord-023095-4dannjjm 5076 29 for for IN cord-023095-4dannjjm 5076 30 its -PRON- PRP$ cord-023095-4dannjjm 5076 31 ability ability NN cord-023095-4dannjjm 5076 32 to to TO cord-023095-4dannjjm 5076 33 reduce reduce VB cord-023095-4dannjjm 5076 34 tumor tumor NN cord-023095-4dannjjm 5076 35 cell cell NN cord-023095-4dannjjm 5076 36 growth growth NN cord-023095-4dannjjm 5076 37 . . . cord-023095-4dannjjm 5077 1 Specifically specifically RB cord-023095-4dannjjm 5077 2 , , , cord-023095-4dannjjm 5077 3 the the DT cord-023095-4dannjjm 5077 4 combination combination NN cord-023095-4dannjjm 5077 5 of of IN cord-023095-4dannjjm 5077 6 rosiglitazone rosiglitazone NN cord-023095-4dannjjm 5077 7 and and CC cord-023095-4dannjjm 5077 8 carboplatin carboplatin NNP cord-023095-4dannjjm 5077 9 has have VBZ cord-023095-4dannjjm 5077 10 demonstrated demonstrate VBN cord-023095-4dannjjm 5077 11 enhanced enhanced JJ cord-023095-4dannjjm 5077 12 tumor tumor NN cord-023095-4dannjjm 5077 13 control control NN cord-023095-4dannjjm 5077 14 . . . cord-023095-4dannjjm 5078 1 The the DT cord-023095-4dannjjm 5078 2 purpose purpose NN cord-023095-4dannjjm 5078 3 of of IN cord-023095-4dannjjm 5078 4 this this DT cord-023095-4dannjjm 5078 5 study study NN cord-023095-4dannjjm 5078 6 was be VBD cord-023095-4dannjjm 5078 7 to to TO cord-023095-4dannjjm 5078 8 determine determine VB cord-023095-4dannjjm 5078 9 the the DT cord-023095-4dannjjm 5078 10 peak peak NN cord-023095-4dannjjm 5078 11 plasma plasma NN cord-023095-4dannjjm 5078 12 concentrations concentration NNS cord-023095-4dannjjm 5078 13 and and CC cord-023095-4dannjjm 5078 14 side side NN cord-023095-4dannjjm 5078 15 effect effect NN cord-023095-4dannjjm 5078 16 profile profile NN cord-023095-4dannjjm 5078 17 of of IN cord-023095-4dannjjm 5078 18 rosiglitazone rosiglitazone NN cord-023095-4dannjjm 5078 19 after after IN cord-023095-4dannjjm 5078 20 oral oral JJ cord-023095-4dannjjm 5078 21 administration administration NN cord-023095-4dannjjm 5078 22 in in IN cord-023095-4dannjjm 5078 23 dogs dog NNS cord-023095-4dannjjm 5078 24 with with IN cord-023095-4dannjjm 5078 25 spontaneously spontaneously RB cord-023095-4dannjjm 5078 26 occurring occur VBG cord-023095-4dannjjm 5078 27 cancer cancer NN cord-023095-4dannjjm 5078 28 . . . cord-023095-4dannjjm 5079 1 All all DT cord-023095-4dannjjm 5079 2 dogs dog NNS cord-023095-4dannjjm 5079 3 received receive VBD cord-023095-4dannjjm 5079 4 carboplatin carboplatin NNS cord-023095-4dannjjm 5079 5 intravenously intravenously RB cord-023095-4dannjjm 5079 6 concurrently concurrently RB cord-023095-4dannjjm 5079 7 with with IN cord-023095-4dannjjm 5079 8 oral oral JJ cord-023095-4dannjjm 5079 9 rosiglitazone rosiglitazone NN cord-023095-4dannjjm 5079 10 . . . cord-023095-4dannjjm 5080 1 Ten ten CD cord-023095-4dannjjm 5080 2 cancer cancer NN cord-023095-4dannjjm 5080 3 - - HYPH cord-023095-4dannjjm 5080 4 bearing bear VBG cord-023095-4dannjjm 5080 5 dogs dog NNS cord-023095-4dannjjm 5080 6 with with IN cord-023095-4dannjjm 5080 7 normal normal JJ cord-023095-4dannjjm 5080 8 pre pre JJ cord-023095-4dannjjm 5080 9 - - JJ cord-023095-4dannjjm 5080 10 treatment treatment JJ cord-023095-4dannjjm 5080 11 hepatic hepatic JJ cord-023095-4dannjjm 5080 12 and and CC cord-023095-4dannjjm 5080 13 renal renal JJ cord-023095-4dannjjm 5080 14 function function NN cord-023095-4dannjjm 5080 15 were be VBD cord-023095-4dannjjm 5080 16 enrolled enrol VBN cord-023095-4dannjjm 5080 17 . . . cord-023095-4dannjjm 5081 1 Complete complete JJ cord-023095-4dannjjm 5081 2 pre pre JJ cord-023095-4dannjjm 5081 3 - - JJ cord-023095-4dannjjm 5081 4 treatment treatment JJ cord-023095-4dannjjm 5081 5 hematological hematological JJ cord-023095-4dannjjm 5081 6 and and CC cord-023095-4dannjjm 5081 7 biochemical biochemical JJ cord-023095-4dannjjm 5081 8 parameters parameter NNS cord-023095-4dannjjm 5081 9 were be VBD cord-023095-4dannjjm 5081 10 available available JJ cord-023095-4dannjjm 5081 11 in in IN cord-023095-4dannjjm 5081 12 ten ten CD cord-023095-4dannjjm 5081 13 dogs dog NNS cord-023095-4dannjjm 5081 14 and and CC cord-023095-4dannjjm 5081 15 post post JJ cord-023095-4dannjjm 5081 16 - - JJ cord-023095-4dannjjm 5081 17 treatment treatment JJ cord-023095-4dannjjm 5081 18 parameters parameter NNS cord-023095-4dannjjm 5081 19 in in IN cord-023095-4dannjjm 5081 20 nine nine CD cord-023095-4dannjjm 5081 21 dogs dog NNS cord-023095-4dannjjm 5081 22 . . . cord-023095-4dannjjm 5082 1 Peak peak NN cord-023095-4dannjjm 5082 2 plasma plasma NN cord-023095-4dannjjm 5082 3 concentrations concentration NNS cord-023095-4dannjjm 5082 4 varied varied JJ cord-023095-4dannjjm 5082 5 with with IN cord-023095-4dannjjm 5082 6 dose dose NN cord-023095-4dannjjm 5082 7 and and CC cord-023095-4dannjjm 5082 8 ranged range VBD cord-023095-4dannjjm 5082 9 from from IN cord-023095-4dannjjm 5082 10 150.3 150.3 CD cord-023095-4dannjjm 5082 11 - - SYM cord-023095-4dannjjm 5082 12 959.4 959.4 CD cord-023095-4dannjjm 5082 13 ng ng NN cord-023095-4dannjjm 5082 14 / / SYM cord-023095-4dannjjm 5082 15 mL ml NN cord-023095-4dannjjm 5082 16 and and CC cord-023095-4dannjjm 5082 17 occurred occur VBD cord-023095-4dannjjm 5082 18 between between IN cord-023095-4dannjjm 5082 19 30 30 CD cord-023095-4dannjjm 5082 20 minutes minute NNS cord-023095-4dannjjm 5082 21 and and CC cord-023095-4dannjjm 5082 22 4 4 CD cord-023095-4dannjjm 5082 23 hours hour NNS cord-023095-4dannjjm 5082 24 post post NN cord-023095-4dannjjm 5082 25 administration administration NN cord-023095-4dannjjm 5082 26 and and CC cord-023095-4dannjjm 5082 27 rapidly rapidly RB cord-023095-4dannjjm 5082 28 declined decline VBD cord-023095-4dannjjm 5082 29 after after IN cord-023095-4dannjjm 5082 30 the the DT cord-023095-4dannjjm 5082 31 peak peak NN cord-023095-4dannjjm 5082 32 . . . cord-023095-4dannjjm 5083 1 The the DT cord-023095-4dannjjm 5083 2 dose dose NN cord-023095-4dannjjm 5083 3 limiting limit VBG cord-023095-4dannjjm 5083 4 toxicity toxicity NN cord-023095-4dannjjm 5083 5 was be VBD cord-023095-4dannjjm 5083 6 hepatic hepatic JJ cord-023095-4dannjjm 5083 7 at at IN cord-023095-4dannjjm 5083 8 a a DT cord-023095-4dannjjm 5083 9 dose dose NN cord-023095-4dannjjm 5083 10 of of IN cord-023095-4dannjjm 5083 11 9 9 CD cord-023095-4dannjjm 5083 12 mg mg NNP cord-023095-4dannjjm 5083 13 / / SYM cord-023095-4dannjjm 5083 14 m m NN cord-023095-4dannjjm 5083 15 2 2 CD cord-023095-4dannjjm 5083 16 . . . cord-023095-4dannjjm 5084 1 There there EX cord-023095-4dannjjm 5084 2 was be VBD cord-023095-4dannjjm 5084 3 one one CD cord-023095-4dannjjm 5084 4 Grade Grade NNP cord-023095-4dannjjm 5084 5 III III NNP cord-023095-4dannjjm 5084 6 , , , cord-023095-4dannjjm 5084 7 two two CD cord-023095-4dannjjm 5084 8 Grade grade NN cord-023095-4dannjjm 5084 9 I -PRON- PRP cord-023095-4dannjjm 5084 10 ALT alt NN cord-023095-4dannjjm 5084 11 , , , cord-023095-4dannjjm 5084 12 and and CC cord-023095-4dannjjm 5084 13 one one CD cord-023095-4dannjjm 5084 14 Grade grade NN cord-023095-4dannjjm 5084 15 III III NNP cord-023095-4dannjjm 5084 16 AST AST NNP cord-023095-4dannjjm 5084 17 elevations elevation NNS cord-023095-4dannjjm 5084 18 noted note VBD cord-023095-4dannjjm 5084 19 . . . cord-023095-4dannjjm 5085 1 No no DT cord-023095-4dannjjm 5085 2 changes change NNS cord-023095-4dannjjm 5085 3 in in IN cord-023095-4dannjjm 5085 4 total total JJ cord-023095-4dannjjm 5085 5 bilirubin bilirubin NN cord-023095-4dannjjm 5085 6 , , , cord-023095-4dannjjm 5085 7 alkaline alkaline JJ cord-023095-4dannjjm 5085 8 phosphatase phosphatase NN cord-023095-4dannjjm 5085 9 , , , cord-023095-4dannjjm 5085 10 or or CC cord-023095-4dannjjm 5085 11 GGT GGT NNP cord-023095-4dannjjm 5085 12 values value NNS cord-023095-4dannjjm 5085 13 were be VBD cord-023095-4dannjjm 5085 14 noted note VBN cord-023095-4dannjjm 5085 15 . . . cord-023095-4dannjjm 5086 1 Blood blood NN cord-023095-4dannjjm 5086 2 glucose glucose NN cord-023095-4dannjjm 5086 3 values value NNS cord-023095-4dannjjm 5086 4 remained remain VBD cord-023095-4dannjjm 5086 5 within within IN cord-023095-4dannjjm 5086 6 normal normal JJ cord-023095-4dannjjm 5086 7 limits limit NNS cord-023095-4dannjjm 5086 8 . . . cord-023095-4dannjjm 5087 1 Mild mild JJ cord-023095-4dannjjm 5087 2 , , , cord-023095-4dannjjm 5087 3 self self NN cord-023095-4dannjjm 5087 4 - - HYPH cord-023095-4dannjjm 5087 5 limiting limit VBG cord-023095-4dannjjm 5087 6 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 5087 7 and and CC cord-023095-4dannjjm 5087 8 hematologic hematologic JJ cord-023095-4dannjjm 5087 9 toxicities toxicity NNS cord-023095-4dannjjm 5087 10 were be VBD cord-023095-4dannjjm 5087 11 observed observe VBN cord-023095-4dannjjm 5087 12 when when WRB cord-023095-4dannjjm 5087 13 rosiglitazone rosiglitazone NN cord-023095-4dannjjm 5087 14 was be VBD cord-023095-4dannjjm 5087 15 administered administer VBN cord-023095-4dannjjm 5087 16 in in IN cord-023095-4dannjjm 5087 17 combination combination NN cord-023095-4dannjjm 5087 18 with with IN cord-023095-4dannjjm 5087 19 carboplatin carboplatin NNS cord-023095-4dannjjm 5087 20 . . . cord-023095-4dannjjm 5088 1 Based base VBN cord-023095-4dannjjm 5088 2 on on IN cord-023095-4dannjjm 5088 3 this this DT cord-023095-4dannjjm 5088 4 study study NN cord-023095-4dannjjm 5088 5 , , , cord-023095-4dannjjm 5088 6 the the DT cord-023095-4dannjjm 5088 7 recommended recommend VBN cord-023095-4dannjjm 5088 8 dose dose NN cord-023095-4dannjjm 5088 9 of of IN cord-023095-4dannjjm 5088 10 rosiglitazone rosiglitazone NN cord-023095-4dannjjm 5088 11 in in IN cord-023095-4dannjjm 5088 12 cancer cancer NN cord-023095-4dannjjm 5088 13 - - HYPH cord-023095-4dannjjm 5088 14 bearing bear VBG cord-023095-4dannjjm 5088 15 dogs dog NNS cord-023095-4dannjjm 5088 16 with with IN cord-023095-4dannjjm 5088 17 normal normal JJ cord-023095-4dannjjm 5088 18 hepatic hepatic JJ cord-023095-4dannjjm 5088 19 function function NN cord-023095-4dannjjm 5088 20 is be VBZ cord-023095-4dannjjm 5088 21 6 6 CD cord-023095-4dannjjm 5088 22 mg mg NNP cord-023095-4dannjjm 5088 23 / / SYM cord-023095-4dannjjm 5088 24 m m NN cord-023095-4dannjjm 5088 25 2 2 CD cord-023095-4dannjjm 5088 26 orally orally RB cord-023095-4dannjjm 5088 27 once once RB cord-023095-4dannjjm 5088 28 daily daily RB cord-023095-4dannjjm 5088 29 . . . cord-023095-4dannjjm 5089 1 Side side JJ cord-023095-4dannjjm 5089 2 effects effect NNS cord-023095-4dannjjm 5089 3 of of IN cord-023095-4dannjjm 5089 4 the the DT cord-023095-4dannjjm 5089 5 combination combination NN cord-023095-4dannjjm 5089 6 appear appear VBP cord-023095-4dannjjm 5089 7 similar similar JJ cord-023095-4dannjjm 5089 8 to to IN cord-023095-4dannjjm 5089 9 side side JJ cord-023095-4dannjjm 5089 10 effects effect NNS cord-023095-4dannjjm 5089 11 noted note VBN cord-023095-4dannjjm 5089 12 with with IN cord-023095-4dannjjm 5089 13 carboplatin carboplatin NNS cord-023095-4dannjjm 5089 14 alone alone RB cord-023095-4dannjjm 5089 15 . . . cord-023095-4dannjjm 5090 1 Further further JJ cord-023095-4dannjjm 5090 2 study study NN cord-023095-4dannjjm 5090 3 is be VBZ cord-023095-4dannjjm 5090 4 needed need VBN cord-023095-4dannjjm 5090 5 to to TO cord-023095-4dannjjm 5090 6 determine determine VB cord-023095-4dannjjm 5090 7 efficacy efficacy NN cord-023095-4dannjjm 5090 8 of of IN cord-023095-4dannjjm 5090 9 this this DT cord-023095-4dannjjm 5090 10 combination combination NN cord-023095-4dannjjm 5090 11 and and CC cord-023095-4dannjjm 5090 12 if if IN cord-023095-4dannjjm 5090 13 more more RBR cord-023095-4dannjjm 5090 14 frequent frequent JJ cord-023095-4dannjjm 5090 15 dosing dosing NN cord-023095-4dannjjm 5090 16 is be VBZ cord-023095-4dannjjm 5090 17 required require VBN cord-023095-4dannjjm 5090 18 to to TO cord-023095-4dannjjm 5090 19 maintain maintain VB cord-023095-4dannjjm 5090 20 plasma plasma NN cord-023095-4dannjjm 5090 21 concentrations concentration NNS cord-023095-4dannjjm 5090 22 . . . cord-023095-4dannjjm 5091 1 Carboplatin Carboplatin NNP cord-023095-4dannjjm 5091 2 has have VBZ cord-023095-4dannjjm 5091 3 shown show VBN cord-023095-4dannjjm 5091 4 little little JJ cord-023095-4dannjjm 5091 5 activity activity NN cord-023095-4dannjjm 5091 6 as as IN cord-023095-4dannjjm 5091 7 a a DT cord-023095-4dannjjm 5091 8 single single JJ cord-023095-4dannjjm 5091 9 agent agent NN cord-023095-4dannjjm 5091 10 for for IN cord-023095-4dannjjm 5091 11 the the DT cord-023095-4dannjjm 5091 12 treatment treatment NN cord-023095-4dannjjm 5091 13 of of IN cord-023095-4dannjjm 5091 14 canine canine JJ cord-023095-4dannjjm 5091 15 transitional transitional JJ cord-023095-4dannjjm 5091 16 cell cell NN cord-023095-4dannjjm 5091 17 carcinoma carcinoma NN cord-023095-4dannjjm 5091 18 ( ( -LRB- cord-023095-4dannjjm 5091 19 TCC tcc NN cord-023095-4dannjjm 5091 20 ) ) -RRB- cord-023095-4dannjjm 5091 21 . . . cord-023095-4dannjjm 5092 1 However however RB cord-023095-4dannjjm 5092 2 , , , cord-023095-4dannjjm 5092 3 gemcitabine gemcitabine NNP cord-023095-4dannjjm 5092 4 has have VBZ cord-023095-4dannjjm 5092 5 shown show VBN cord-023095-4dannjjm 5092 6 synergism synergism NN cord-023095-4dannjjm 5092 7 with with IN cord-023095-4dannjjm 5092 8 carboplatin carboplatin NNS cord-023095-4dannjjm 5092 9 in in IN cord-023095-4dannjjm 5092 10 human human JJ cord-023095-4dannjjm 5092 11 cell cell NN cord-023095-4dannjjm 5092 12 lines line NNS cord-023095-4dannjjm 5092 13 . . . cord-023095-4dannjjm 5093 1 The the DT cord-023095-4dannjjm 5093 2 purpose purpose NN cord-023095-4dannjjm 5093 3 of of IN cord-023095-4dannjjm 5093 4 this this DT cord-023095-4dannjjm 5093 5 study study NN cord-023095-4dannjjm 5093 6 was be VBD cord-023095-4dannjjm 5093 7 to to TO cord-023095-4dannjjm 5093 8 evaluate evaluate VB cord-023095-4dannjjm 5093 9 the the DT cord-023095-4dannjjm 5093 10 activity activity NN cord-023095-4dannjjm 5093 11 of of IN cord-023095-4dannjjm 5093 12 gemcitabine gemcitabine NN cord-023095-4dannjjm 5093 13 against against IN cord-023095-4dannjjm 5093 14 canine canine JJ cord-023095-4dannjjm 5093 15 TCC TCC NNP cord-023095-4dannjjm 5093 16 cell cell NN cord-023095-4dannjjm 5093 17 lines line NNS cord-023095-4dannjjm 5093 18 alone alone RB cord-023095-4dannjjm 5093 19 or or CC cord-023095-4dannjjm 5093 20 in in IN cord-023095-4dannjjm 5093 21 combination combination NN cord-023095-4dannjjm 5093 22 with with IN cord-023095-4dannjjm 5093 23 carboplatin carboplatin NNS cord-023095-4dannjjm 5093 24 . . . cord-023095-4dannjjm 5094 1 We -PRON- PRP cord-023095-4dannjjm 5094 2 hypothesized hypothesize VBD cord-023095-4dannjjm 5094 3 that that IN cord-023095-4dannjjm 5094 4 gemcitabine gemcitabine NN cord-023095-4dannjjm 5094 5 in in IN cord-023095-4dannjjm 5094 6 combination combination NN cord-023095-4dannjjm 5094 7 with with IN cord-023095-4dannjjm 5094 8 carboplatin carboplatin NNS cord-023095-4dannjjm 5094 9 would would MD cord-023095-4dannjjm 5094 10 have have VB cord-023095-4dannjjm 5094 11 synergistic synergistic JJ cord-023095-4dannjjm 5094 12 effects effect NNS cord-023095-4dannjjm 5094 13 in in IN cord-023095-4dannjjm 5094 14 vitro vitro FW cord-023095-4dannjjm 5094 15 . . . cord-023095-4dannjjm 5095 1 The the DT cord-023095-4dannjjm 5095 2 results result NNS cord-023095-4dannjjm 5095 3 of of IN cord-023095-4dannjjm 5095 4 this this DT cord-023095-4dannjjm 5095 5 study study NN cord-023095-4dannjjm 5095 6 could could MD cord-023095-4dannjjm 5095 7 provide provide VB cord-023095-4dannjjm 5095 8 a a DT cord-023095-4dannjjm 5095 9 rationale rationale NN cord-023095-4dannjjm 5095 10 for for IN cord-023095-4dannjjm 5095 11 treatment treatment NN cord-023095-4dannjjm 5095 12 of of IN cord-023095-4dannjjm 5095 13 canine canine JJ cord-023095-4dannjjm 5095 14 TCC tcc NN cord-023095-4dannjjm 5095 15 with with IN cord-023095-4dannjjm 5095 16 the the DT cord-023095-4dannjjm 5095 17 combination combination NN cord-023095-4dannjjm 5095 18 of of IN cord-023095-4dannjjm 5095 19 these these DT cord-023095-4dannjjm 5095 20 drugs drug NNS cord-023095-4dannjjm 5095 21 . . . cord-023095-4dannjjm 5096 1 TCC TCC NNP cord-023095-4dannjjm 5096 2 cell cell NN cord-023095-4dannjjm 5096 3 lines line NNS cord-023095-4dannjjm 5097 1 TCC TCC NNP cord-023095-4dannjjm 5097 2 - - HYPH cord-023095-4dannjjm 5097 3 Kiss Kiss NNP cord-023095-4dannjjm 5097 4 , , , cord-023095-4dannjjm 5097 5 TCC TCC NNP cord-023095-4dannjjm 5097 6 - - HYPH cord-023095-4dannjjm 5097 7 Knapp Knapp NNP cord-023095-4dannjjm 5097 8 - - HYPH cord-023095-4dannjjm 5097 9 JS JS NNP cord-023095-4dannjjm 5097 10 , , , cord-023095-4dannjjm 5097 11 TCC TCC NNP cord-023095-4dannjjm 5097 12 - - HYPH cord-023095-4dannjjm 5097 13 AXA AXA NNP cord-023095-4dannjjm 5097 14 , , , cord-023095-4dannjjm 5097 15 TCC TCC NNP cord-023095-4dannjjm 5097 16 - - HYPH cord-023095-4dannjjm 5097 17 HXC HXC NNP cord-023095-4dannjjm 5097 18 , , , cord-023095-4dannjjm 5097 19 and and CC cord-023095-4dannjjm 5097 20 TCC tcc NN cord-023095-4dannjjm 5097 21 - - HYPH cord-023095-4dannjjm 5097 22 SH SH NNP cord-023095-4dannjjm 5097 23 were be VBD cord-023095-4dannjjm 5097 24 treated treat VBN cord-023095-4dannjjm 5097 25 with with IN cord-023095-4dannjjm 5097 26 gemcitabine gemcitabine NNP cord-023095-4dannjjm 5097 27 , , , cord-023095-4dannjjm 5097 28 carboplatin carboplatin NNP cord-023095-4dannjjm 5097 29 , , , cord-023095-4dannjjm 5097 30 or or CC cord-023095-4dannjjm 5097 31 the the DT cord-023095-4dannjjm 5097 32 combination combination NN cord-023095-4dannjjm 5097 33 . . . cord-023095-4dannjjm 5098 1 Cell cell NN cord-023095-4dannjjm 5098 2 proliferation proliferation NN cord-023095-4dannjjm 5098 3 was be VBD cord-023095-4dannjjm 5098 4 assessed assess VBN cord-023095-4dannjjm 5098 5 using use VBG cord-023095-4dannjjm 5098 6 CyQUANT CyQUANT NNP cord-023095-4dannjjm 5098 7 assay assay NN cord-023095-4dannjjm 5098 8 , , , cord-023095-4dannjjm 5098 9 cell cell NN cord-023095-4dannjjm 5098 10 cycle cycle NN cord-023095-4dannjjm 5098 11 was be VBD cord-023095-4dannjjm 5098 12 evaluated evaluate VBN cord-023095-4dannjjm 5098 13 using use VBG cord-023095-4dannjjm 5098 14 propidium propidium NN cord-023095-4dannjjm 5098 15 iodide iodide NN cord-023095-4dannjjm 5098 16 staining staining NN cord-023095-4dannjjm 5098 17 , , , cord-023095-4dannjjm 5098 18 and and CC cord-023095-4dannjjm 5098 19 apoptosis apoptosis NN cord-023095-4dannjjm 5098 20 was be VBD cord-023095-4dannjjm 5098 21 assessed assess VBN cord-023095-4dannjjm 5098 22 by by IN cord-023095-4dannjjm 5098 23 measuring measure VBG cord-023095-4dannjjm 5098 24 caspase-3/7 caspase-3/7 NNP cord-023095-4dannjjm 5098 25 activation activation NN cord-023095-4dannjjm 5098 26 . . . cord-023095-4dannjjm 5099 1 Synergy Synergy NNP cord-023095-4dannjjm 5099 2 was be VBD cord-023095-4dannjjm 5099 3 quantified quantify VBN cord-023095-4dannjjm 5099 4 by by IN cord-023095-4dannjjm 5099 5 combination combination NN cord-023095-4dannjjm 5099 6 index index NN cord-023095-4dannjjm 5099 7 analysis analysis NN cord-023095-4dannjjm 5099 8 using use VBG cord-023095-4dannjjm 5099 9 Compusyn Compusyn NNP cord-023095-4dannjjm 5099 10 software software NN cord-023095-4dannjjm 5099 11 . . . cord-023095-4dannjjm 5100 1 Treatment treatment NN cord-023095-4dannjjm 5100 2 of of IN cord-023095-4dannjjm 5100 3 canine canine JJ cord-023095-4dannjjm 5100 4 TCC TCC NNP cord-023095-4dannjjm 5100 5 cell cell NN cord-023095-4dannjjm 5100 6 lines line NNS cord-023095-4dannjjm 5100 7 with with IN cord-023095-4dannjjm 5100 8 carboplatin carboplatin NNP cord-023095-4dannjjm 5100 9 or or CC cord-023095-4dannjjm 5100 10 gemcitabine gemcitabine NNP cord-023095-4dannjjm 5100 11 decreased decrease VBD cord-023095-4dannjjm 5100 12 cell cell NN cord-023095-4dannjjm 5100 13 proliferation proliferation NN cord-023095-4dannjjm 5100 14 , , , cord-023095-4dannjjm 5100 15 induced induce VBN cord-023095-4dannjjm 5100 16 cell cell NN cord-023095-4dannjjm 5100 17 cycle cycle NN cord-023095-4dannjjm 5100 18 arrest arrest NN cord-023095-4dannjjm 5100 19 , , , cord-023095-4dannjjm 5100 20 and and CC cord-023095-4dannjjm 5100 21 apoptosis apoptosis NN cord-023095-4dannjjm 5100 22 . . . cord-023095-4dannjjm 5101 1 When when WRB cord-023095-4dannjjm 5101 2 TCC TCC NNP cord-023095-4dannjjm 5101 3 cell cell NN cord-023095-4dannjjm 5101 4 lines line NNS cord-023095-4dannjjm 5101 5 were be VBD cord-023095-4dannjjm 5101 6 treated treat VBN cord-023095-4dannjjm 5101 7 with with IN cord-023095-4dannjjm 5101 8 gemcitabine gemcitabine NNP cord-023095-4dannjjm 5101 9 and and CC cord-023095-4dannjjm 5101 10 carboplatin carboplatin NNPS cord-023095-4dannjjm 5101 11 in in IN cord-023095-4dannjjm 5101 12 combination combination NN cord-023095-4dannjjm 5101 13 at at IN cord-023095-4dannjjm 5101 14 a a DT cord-023095-4dannjjm 5101 15 therapeutically therapeutically RB cord-023095-4dannjjm 5101 16 relevant relevant JJ cord-023095-4dannjjm 5101 17 concentration concentration NN cord-023095-4dannjjm 5101 18 ( ( -LRB- cord-023095-4dannjjm 5101 19 gemcitabine gemcitabine NNP cord-023095-4dannjjm 5101 20 o o NNP cord-023095-4dannjjm 5101 21 100uM 100uM NNP cord-023095-4dannjjm 5101 22 , , , cord-023095-4dannjjm 5101 23 carboplatin carboplatin NNP cord-023095-4dannjjm 5101 24 o o NNP cord-023095-4dannjjm 5101 25 250uM 250uM NNP cord-023095-4dannjjm 5101 26 ) ) -RRB- cord-023095-4dannjjm 5101 27 , , , cord-023095-4dannjjm 5101 28 a a DT cord-023095-4dannjjm 5101 29 significant significant JJ cord-023095-4dannjjm 5101 30 decrease decrease NN cord-023095-4dannjjm 5101 31 in in IN cord-023095-4dannjjm 5101 32 cell cell NN cord-023095-4dannjjm 5101 33 proliferation proliferation NN cord-023095-4dannjjm 5101 34 was be VBD cord-023095-4dannjjm 5101 35 observed observe VBN cord-023095-4dannjjm 5101 36 compared compare VBN cord-023095-4dannjjm 5101 37 to to IN cord-023095-4dannjjm 5101 38 gemcitabine gemcitabine NNP cord-023095-4dannjjm 5101 39 or or CC cord-023095-4dannjjm 5101 40 carboplatin carboplatin VB cord-023095-4dannjjm 5101 41 alone alone RB cord-023095-4dannjjm 5101 42 , , , cord-023095-4dannjjm 5101 43 and and CC cord-023095-4dannjjm 5101 44 the the DT cord-023095-4dannjjm 5101 45 drug drug NN cord-023095-4dannjjm 5101 46 combination combination NN cord-023095-4dannjjm 5101 47 was be VBD cord-023095-4dannjjm 5101 48 synergistic synergistic JJ cord-023095-4dannjjm 5101 49 in in IN cord-023095-4dannjjm 5101 50 3 3 CD cord-023095-4dannjjm 5101 51 of of IN cord-023095-4dannjjm 5101 52 5 5 CD cord-023095-4dannjjm 5101 53 cell cell NN cord-023095-4dannjjm 5101 54 lines line NNS cord-023095-4dannjjm 5101 55 , , , cord-023095-4dannjjm 5101 56 and and CC cord-023095-4dannjjm 5101 57 additive additive NN cord-023095-4dannjjm 5101 58 in in IN cord-023095-4dannjjm 5101 59 the the DT cord-023095-4dannjjm 5101 60 remaining remain VBG cord-023095-4dannjjm 5101 61 2 2 CD cord-023095-4dannjjm 5101 62 lines line NNS cord-023095-4dannjjm 5101 63 . . . cord-023095-4dannjjm 5102 1 Gemcitabine Gemcitabine NNP cord-023095-4dannjjm 5102 2 exhibits exhibit VBZ cord-023095-4dannjjm 5102 3 biologic biologic JJ cord-023095-4dannjjm 5102 4 activity activity NN cord-023095-4dannjjm 5102 5 against against IN cord-023095-4dannjjm 5102 6 canine canine JJ cord-023095-4dannjjm 5102 7 TCC TCC NNP cord-023095-4dannjjm 5102 8 cell cell NN cord-023095-4dannjjm 5102 9 lines line NNS cord-023095-4dannjjm 5102 10 and and CC cord-023095-4dannjjm 5102 11 carboplatin carboplatin NNS cord-023095-4dannjjm 5102 12 combined combine VBN cord-023095-4dannjjm 5102 13 with with IN cord-023095-4dannjjm 5102 14 gemcitabine gemcitabine NNP cord-023095-4dannjjm 5103 1 exhibits exhibit VBZ cord-023095-4dannjjm 5103 2 synergistic synergistic JJ cord-023095-4dannjjm 5103 3 activity activity NN cord-023095-4dannjjm 5103 4 at at IN cord-023095-4dannjjm 5103 5 biologically biologically RB cord-023095-4dannjjm 5103 6 relevant relevant JJ cord-023095-4dannjjm 5103 7 concentrations concentration NNS cord-023095-4dannjjm 5103 8 . . . cord-023095-4dannjjm 5104 1 Our -PRON- PRP$ cord-023095-4dannjjm 5104 2 results result NNS cord-023095-4dannjjm 5104 3 support support VBP cord-023095-4dannjjm 5104 4 further further JJ cord-023095-4dannjjm 5104 5 evaluation evaluation NN cord-023095-4dannjjm 5104 6 of of IN cord-023095-4dannjjm 5104 7 these these DT cord-023095-4dannjjm 5104 8 drugs drug NNS cord-023095-4dannjjm 5104 9 in in IN cord-023095-4dannjjm 5104 10 dogs dog NNS cord-023095-4dannjjm 5104 11 with with IN cord-023095-4dannjjm 5104 12 TCC TCC NNP cord-023095-4dannjjm 5104 13 to to TO cord-023095-4dannjjm 5104 14 determine determine VB cord-023095-4dannjjm 5104 15 the the DT cord-023095-4dannjjm 5104 16 clinical clinical JJ cord-023095-4dannjjm 5104 17 efficacy efficacy NN cord-023095-4dannjjm 5104 18 of of IN cord-023095-4dannjjm 5104 19 this this DT cord-023095-4dannjjm 5104 20 combination combination NN cord-023095-4dannjjm 5104 21 . . . cord-023095-4dannjjm 5105 1 Metronomic metronomic JJ cord-023095-4dannjjm 5105 2 chemotherapy chemotherapy NN cord-023095-4dannjjm 5105 3 has have VBZ cord-023095-4dannjjm 5105 4 been be VBN cord-023095-4dannjjm 5105 5 shown show VBN cord-023095-4dannjjm 5105 6 in in IN cord-023095-4dannjjm 5105 7 murine murine JJ cord-023095-4dannjjm 5105 8 models model NNS cord-023095-4dannjjm 5105 9 and and CC cord-023095-4dannjjm 5105 10 humans human NNS cord-023095-4dannjjm 5105 11 to to TO cord-023095-4dannjjm 5105 12 improve improve VB cord-023095-4dannjjm 5105 13 tumor tumor NN cord-023095-4dannjjm 5105 14 control control NN cord-023095-4dannjjm 5105 15 by by IN cord-023095-4dannjjm 5105 16 inhibiting inhibit VBG cord-023095-4dannjjm 5105 17 tumor tumor NN cord-023095-4dannjjm 5105 18 angiogenesis angiogenesis NN cord-023095-4dannjjm 5105 19 and and CC cord-023095-4dannjjm 5105 20 suppressing suppress VBG cord-023095-4dannjjm 5105 21 regulatory regulatory JJ cord-023095-4dannjjm 5105 22 T t NN cord-023095-4dannjjm 5105 23 cells cell NNS cord-023095-4dannjjm 5105 24 ( ( -LRB- cord-023095-4dannjjm 5105 25 Treg Treg NNP cord-023095-4dannjjm 5105 26 ) ) -RRB- cord-023095-4dannjjm 5105 27 . . . cord-023095-4dannjjm 5106 1 Treg Treg NNP cord-023095-4dannjjm 5106 2 are be VBP cord-023095-4dannjjm 5106 3 a a DT cord-023095-4dannjjm 5106 4 subset subset NN cord-023095-4dannjjm 5106 5 of of IN cord-023095-4dannjjm 5106 6 T t NN cord-023095-4dannjjm 5106 7 lymphocytes lymphocyte NNS cord-023095-4dannjjm 5106 8 demonstrated demonstrate VBN cord-023095-4dannjjm 5106 9 to to TO cord-023095-4dannjjm 5106 10 be be VB cord-023095-4dannjjm 5106 11 increased increase VBN cord-023095-4dannjjm 5106 12 in in IN cord-023095-4dannjjm 5106 13 humans human NNS cord-023095-4dannjjm 5106 14 and and CC cord-023095-4dannjjm 5106 15 dogs dog NNS cord-023095-4dannjjm 5106 16 with with IN cord-023095-4dannjjm 5106 17 cancer cancer NN cord-023095-4dannjjm 5106 18 and and CC cord-023095-4dannjjm 5106 19 are be VBP cord-023095-4dannjjm 5106 20 thought think VBN cord-023095-4dannjjm 5106 21 to to TO cord-023095-4dannjjm 5106 22 suppress suppress VB cord-023095-4dannjjm 5106 23 cellular cellular JJ cord-023095-4dannjjm 5106 24 immune immune JJ cord-023095-4dannjjm 5106 25 responses response NNS cord-023095-4dannjjm 5106 26 against against IN cord-023095-4dannjjm 5106 27 tumors tumor NNS cord-023095-4dannjjm 5106 28 . . . cord-023095-4dannjjm 5107 1 The the DT cord-023095-4dannjjm 5107 2 purpose purpose NN cord-023095-4dannjjm 5107 3 of of IN cord-023095-4dannjjm 5107 4 this this DT cord-023095-4dannjjm 5107 5 study study NN cord-023095-4dannjjm 5107 6 was be VBD cord-023095-4dannjjm 5107 7 to to TO cord-023095-4dannjjm 5107 8 determine determine VB cord-023095-4dannjjm 5107 9 whether whether IN cord-023095-4dannjjm 5107 10 metronomic metronomic JJ cord-023095-4dannjjm 5107 11 cyclophosphamide cyclophosphamide JJ cord-023095-4dannjjm 5107 12 therapy therapy NN cord-023095-4dannjjm 5107 13 depletes deplete VBZ cord-023095-4dannjjm 5107 14 Treg Treg NNP cord-023095-4dannjjm 5107 15 and/or and/or CC cord-023095-4dannjjm 5107 16 exhibits exhibit VBZ cord-023095-4dannjjm 5107 17 antiangiogenic antiangiogenic JJ cord-023095-4dannjjm 5107 18 activity activity NN cord-023095-4dannjjm 5107 19 in in IN cord-023095-4dannjjm 5107 20 dogs dog NNS cord-023095-4dannjjm 5107 21 with with IN cord-023095-4dannjjm 5107 22 soft soft JJ cord-023095-4dannjjm 5107 23 tissue tissue NN cord-023095-4dannjjm 5107 24 sarcoma sarcoma NN cord-023095-4dannjjm 5107 25 . . . cord-023095-4dannjjm 5108 1 Client client NN cord-023095-4dannjjm 5108 2 owned own VBD cord-023095-4dannjjm 5108 3 dogs dog NNS cord-023095-4dannjjm 5109 1 with with IN cord-023095-4dannjjm 5109 2 histologically histologically RB cord-023095-4dannjjm 5109 3 confirmed confirm VBN cord-023095-4dannjjm 5109 4 grade grade NN cord-023095-4dannjjm 5109 5 I -PRON- PRP cord-023095-4dannjjm 5109 6 or or CC cord-023095-4dannjjm 5109 7 II ii CD cord-023095-4dannjjm 5109 8 soft soft JJ cord-023095-4dannjjm 5109 9 tissue tissue NN cord-023095-4dannjjm 5109 10 sarcoma sarcoma NN cord-023095-4dannjjm 5109 11 were be VBD cord-023095-4dannjjm 5109 12 administered administer VBN cord-023095-4dannjjm 5109 13 cyclophosphamide cyclophosphamide RB cord-023095-4dannjjm 5109 14 at at IN cord-023095-4dannjjm 5109 15 12.5 12.5 CD cord-023095-4dannjjm 5109 16 mg mg NNP cord-023095-4dannjjm 5109 17 / / SYM cord-023095-4dannjjm 5109 18 m m NNP cord-023095-4dannjjm 5109 19 2 2 CD cord-023095-4dannjjm 5109 20 or or CC cord-023095-4dannjjm 5109 21 15 15 CD cord-023095-4dannjjm 5110 1 mg mg NNP cord-023095-4dannjjm 5110 2 / / SYM cord-023095-4dannjjm 5110 3 m m NNP cord-023095-4dannjjm 5110 4 2 2 CD cord-023095-4dannjjm 5110 5 orally orally RB cord-023095-4dannjjm 5110 6 once once RB cord-023095-4dannjjm 5110 7 daily daily RB cord-023095-4dannjjm 5110 8 for for IN cord-023095-4dannjjm 5110 9 28 28 CD cord-023095-4dannjjm 5110 10 days day NNS cord-023095-4dannjjm 5110 11 . . . cord-023095-4dannjjm 5111 1 Whole whole JJ cord-023095-4dannjjm 5111 2 blood blood NN cord-023095-4dannjjm 5111 3 and and CC cord-023095-4dannjjm 5111 4 tumor tumor NN cord-023095-4dannjjm 5111 5 biopsies biopsy NNS cord-023095-4dannjjm 5111 6 were be VBD cord-023095-4dannjjm 5111 7 obtained obtain VBN cord-023095-4dannjjm 5111 8 on on IN cord-023095-4dannjjm 5111 9 days day NNS cord-023095-4dannjjm 5111 10 0 0 CD cord-023095-4dannjjm 5111 11 , , , cord-023095-4dannjjm 5111 12 14 14 CD cord-023095-4dannjjm 5111 13 , , , cord-023095-4dannjjm 5111 14 and and CC cord-023095-4dannjjm 5111 15 28 28 CD cord-023095-4dannjjm 5111 16 . . . cord-023095-4dannjjm 5112 1 Flow flow VB cord-023095-4dannjjm 5112 2 cytometric cytometric NN cord-023095-4dannjjm 5112 3 analysis analysis NN cord-023095-4dannjjm 5112 4 of of IN cord-023095-4dannjjm 5112 5 blood blood NN cord-023095-4dannjjm 5112 6 was be VBD cord-023095-4dannjjm 5112 7 performed perform VBN cord-023095-4dannjjm 5112 8 to to TO cord-023095-4dannjjm 5112 9 assess assess VB cord-023095-4dannjjm 5112 10 changes change NNS cord-023095-4dannjjm 5112 11 in in IN cord-023095-4dannjjm 5112 12 T T NNP cord-023095-4dannjjm 5112 13 lymphocyte lymphocyte NN cord-023095-4dannjjm 5112 14 subsets subset NNS cord-023095-4dannjjm 5112 15 , , , cord-023095-4dannjjm 5112 16 including include VBG cord-023095-4dannjjm 5112 17 CD4 CD4 NNP cord-023095-4dannjjm 5112 18 1 1 CD cord-023095-4dannjjm 5112 19 and and CC cord-023095-4dannjjm 5112 20 CD8 CD8 NNP cord-023095-4dannjjm 5112 21 1 1 CD cord-023095-4dannjjm 5112 22 cells cell NNS cord-023095-4dannjjm 5112 23 as as RB cord-023095-4dannjjm 5112 24 well well RB cord-023095-4dannjjm 5112 25 as as IN cord-023095-4dannjjm 5112 26 CD4 CD4 NNP cord-023095-4dannjjm 5112 27 1 1 CD cord-023095-4dannjjm 5112 28 FoxP3 FoxP3 NNP cord-023095-4dannjjm 5112 29 1 1 CD cord-023095-4dannjjm 5112 30 Treg Treg NNP cord-023095-4dannjjm 5112 31 . . . cord-023095-4dannjjm 5113 1 Tumor tumor NN cord-023095-4dannjjm 5113 2 microvessel microvessel NN cord-023095-4dannjjm 5113 3 density density NN cord-023095-4dannjjm 5113 4 ( ( -LRB- cord-023095-4dannjjm 5113 5 MVD MVD NNP cord-023095-4dannjjm 5113 6 ) ) -RRB- cord-023095-4dannjjm 5113 7 was be VBD cord-023095-4dannjjm 5113 8 assessed assess VBN cord-023095-4dannjjm 5113 9 by by IN cord-023095-4dannjjm 5113 10 performing perform VBG cord-023095-4dannjjm 5113 11 immunohistochemistry immunohistochemistry NN cord-023095-4dannjjm 5113 12 for for IN cord-023095-4dannjjm 5113 13 CD146 CD146 NNP cord-023095-4dannjjm 5113 14 . . . cord-023095-4dannjjm 5114 1 Five five CD cord-023095-4dannjjm 5114 2 dogs dog NNS cord-023095-4dannjjm 5114 3 were be VBD cord-023095-4dannjjm 5114 4 enrolled enrol VBN cord-023095-4dannjjm 5114 5 in in IN cord-023095-4dannjjm 5114 6 the the DT cord-023095-4dannjjm 5114 7 12.5 12.5 CD cord-023095-4dannjjm 5114 8 mg mg NNP cord-023095-4dannjjm 5114 9 / / SYM cord-023095-4dannjjm 5114 10 m m NNP cord-023095-4dannjjm 5114 11 2 2 CD cord-023095-4dannjjm 5114 12 /day /day CD cord-023095-4dannjjm 5114 13 dose dose NN cord-023095-4dannjjm 5114 14 cohort cohort NN cord-023095-4dannjjm 5114 15 and and CC cord-023095-4dannjjm 5114 16 six six CD cord-023095-4dannjjm 5114 17 dogs dog NNS cord-023095-4dannjjm 5114 18 were be VBD cord-023095-4dannjjm 5114 19 enrolled enrol VBN cord-023095-4dannjjm 5114 20 in in IN cord-023095-4dannjjm 5114 21 the the DT cord-023095-4dannjjm 5114 22 15.0 15.0 CD cord-023095-4dannjjm 5114 23 mg mg NNP cord-023095-4dannjjm 5114 24 / / SYM cord-023095-4dannjjm 5114 25 m m NN cord-023095-4dannjjm 5114 26 2 2 CD cord-023095-4dannjjm 5114 27 /day /day CD cord-023095-4dannjjm 5114 28 dose dose NN cord-023095-4dannjjm 5114 29 cohort cohort NN cord-023095-4dannjjm 5114 30 . . . cord-023095-4dannjjm 5115 1 In in IN cord-023095-4dannjjm 5115 2 patients patient NNS cord-023095-4dannjjm 5115 3 that that WDT cord-023095-4dannjjm 5115 4 received receive VBD cord-023095-4dannjjm 5115 5 cyclophosphamide cyclophosphamide RB cord-023095-4dannjjm 5115 6 at at IN cord-023095-4dannjjm 5115 7 12.5 12.5 CD cord-023095-4dannjjm 5115 8 mg mg NNP cord-023095-4dannjjm 5115 9 / / SYM cord-023095-4dannjjm 5115 10 m m NNP cord-023095-4dannjjm 5115 11 2 2 CD cord-023095-4dannjjm 5115 12 /day /day CD cord-023095-4dannjjm 5115 13 , , , cord-023095-4dannjjm 5115 14 the the DT cord-023095-4dannjjm 5115 15 mean mean JJ cord-023095-4dannjjm 5115 16 number number NN cord-023095-4dannjjm 5115 17 of of IN cord-023095-4dannjjm 5115 18 Treg Treg NNP cord-023095-4dannjjm 5115 19 decreased decrease VBD cord-023095-4dannjjm 5115 20 from from IN cord-023095-4dannjjm 5115 21 day day NN cord-023095-4dannjjm 5115 22 0 0 CD cord-023095-4dannjjm 5115 23 to to IN cord-023095-4dannjjm 5115 24 28 28 CD cord-023095-4dannjjm 5115 25 but but CC cord-023095-4dannjjm 5115 26 there there EX cord-023095-4dannjjm 5115 27 was be VBD cord-023095-4dannjjm 5115 28 no no DT cord-023095-4dannjjm 5115 29 change change NN cord-023095-4dannjjm 5115 30 in in IN cord-023095-4dannjjm 5115 31 the the DT cord-023095-4dannjjm 5115 32 mean mean JJ cord-023095-4dannjjm 5115 33 percentage percentage NN cord-023095-4dannjjm 5115 34 of of IN cord-023095-4dannjjm 5115 35 Treg Treg NNP cord-023095-4dannjjm 5115 36 or or CC cord-023095-4dannjjm 5115 37 MVD MVD NNP cord-023095-4dannjjm 5115 38 . . . cord-023095-4dannjjm 5116 1 For for IN cord-023095-4dannjjm 5116 2 patients patient NNS cord-023095-4dannjjm 5116 3 that that WDT cord-023095-4dannjjm 5116 4 received receive VBD cord-023095-4dannjjm 5116 5 15.0 15.0 CD cord-023095-4dannjjm 5116 6 mg mg NNP cord-023095-4dannjjm 5116 7 / / SYM cord-023095-4dannjjm 5116 8 m m NN cord-023095-4dannjjm 5116 9 2 2 CD cord-023095-4dannjjm 5116 10 /day /day CD cord-023095-4dannjjm 5116 11 , , , cord-023095-4dannjjm 5116 12 both both CC cord-023095-4dannjjm 5116 13 the the DT cord-023095-4dannjjm 5116 14 mean mean JJ cord-023095-4dannjjm 5116 15 number number NN cord-023095-4dannjjm 5116 16 and and CC cord-023095-4dannjjm 5116 17 percent percent NN cord-023095-4dannjjm 5116 18 of of IN cord-023095-4dannjjm 5116 19 Treg Treg NNP cord-023095-4dannjjm 5116 20 as as RB cord-023095-4dannjjm 5116 21 well well RB cord-023095-4dannjjm 5116 22 as as IN cord-023095-4dannjjm 5116 23 MVD MVD NNP cord-023095-4dannjjm 5116 24 decreased decrease VBD cord-023095-4dannjjm 5116 25 over over IN cord-023095-4dannjjm 5116 26 the the DT cord-023095-4dannjjm 5116 27 28 28 CD cord-023095-4dannjjm 5116 28 day day NN cord-023095-4dannjjm 5116 29 time time NN cord-023095-4dannjjm 5116 30 period period NN cord-023095-4dannjjm 5116 31 . . . cord-023095-4dannjjm 5117 1 Cyclophosphamide Cyclophosphamide NNP cord-023095-4dannjjm 5117 2 at at IN cord-023095-4dannjjm 5117 3 15.0 15.0 CD cord-023095-4dannjjm 5117 4 mg mg NNP cord-023095-4dannjjm 5117 5 / / SYM cord-023095-4dannjjm 5117 6 m m NN cord-023095-4dannjjm 5117 7 2 2 CD cord-023095-4dannjjm 5117 8 /day /day . cord-023095-4dannjjm 5117 9 or or CC cord-023095-4dannjjm 5117 10 greater great JJR cord-023095-4dannjjm 5117 11 selectively selectively RB cord-023095-4dannjjm 5117 12 depletes deplete VBZ cord-023095-4dannjjm 5117 13 Treg Treg NNP cord-023095-4dannjjm 5117 14 and and CC cord-023095-4dannjjm 5117 15 inhibits inhibit VBZ cord-023095-4dannjjm 5117 16 angiogenesis angiogenesis NN cord-023095-4dannjjm 5117 17 in in IN cord-023095-4dannjjm 5117 18 dogs dog NNS cord-023095-4dannjjm 5117 19 with with IN cord-023095-4dannjjm 5117 20 soft soft JJ cord-023095-4dannjjm 5117 21 tissue tissue NN cord-023095-4dannjjm 5117 22 sarcoma sarcoma NN cord-023095-4dannjjm 5117 23 . . . cord-023095-4dannjjm 5118 1 Arsenic arsenic NN cord-023095-4dannjjm 5118 2 trioxide trioxide NN cord-023095-4dannjjm 5118 3 ( ( -LRB- cord-023095-4dannjjm 5118 4 ATO ATO NNP cord-023095-4dannjjm 5118 5 ) ) -RRB- cord-023095-4dannjjm 5118 6 is be VBZ cord-023095-4dannjjm 5118 7 used use VBN cord-023095-4dannjjm 5118 8 to to TO cord-023095-4dannjjm 5118 9 treat treat VB cord-023095-4dannjjm 5118 10 leukemias leukemia NNS cord-023095-4dannjjm 5118 11 , , , cord-023095-4dannjjm 5118 12 multiple multiple JJ cord-023095-4dannjjm 5118 13 myeloma myeloma NN cord-023095-4dannjjm 5118 14 , , , cord-023095-4dannjjm 5118 15 and and CC cord-023095-4dannjjm 5118 16 relapsed relapse VBN cord-023095-4dannjjm 5118 17 lymphoid lymphoid JJ cord-023095-4dannjjm 5118 18 malignancies malignancy NNS cord-023095-4dannjjm 5118 19 in in IN cord-023095-4dannjjm 5118 20 humans human NNS cord-023095-4dannjjm 5118 21 ; ; : cord-023095-4dannjjm 5118 22 its -PRON- PRP$ cord-023095-4dannjjm 5118 23 use use NN cord-023095-4dannjjm 5118 24 has have VBZ cord-023095-4dannjjm 5118 25 not not RB cord-023095-4dannjjm 5118 26 been be VBN cord-023095-4dannjjm 5118 27 explored explore VBN cord-023095-4dannjjm 5118 28 in in IN cord-023095-4dannjjm 5118 29 veterinary veterinary JJ cord-023095-4dannjjm 5118 30 oncology oncology NN cord-023095-4dannjjm 5118 31 . . . cord-023095-4dannjjm 5119 1 Prior prior JJ cord-023095-4dannjjm 5119 2 therapy therapy NN cord-023095-4dannjjm 5119 3 with with IN cord-023095-4dannjjm 5119 4 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 5119 5 decreases decrease VBZ cord-023095-4dannjjm 5119 6 likelihood likelihood NN cord-023095-4dannjjm 5119 7 and and CC cord-023095-4dannjjm 5119 8 duration duration NN cord-023095-4dannjjm 5119 9 of of IN cord-023095-4dannjjm 5119 10 remission remission NN cord-023095-4dannjjm 5119 11 for for IN cord-023095-4dannjjm 5119 12 dogs dog NNS cord-023095-4dannjjm 5119 13 with with IN cord-023095-4dannjjm 5119 14 lymphoma lymphoma NN cord-023095-4dannjjm 5119 15 treated treat VBN cord-023095-4dannjjm 5119 16 with with IN cord-023095-4dannjjm 5119 17 chemotherapy chemotherapy NN cord-023095-4dannjjm 5119 18 . . . cord-023095-4dannjjm 5120 1 We -PRON- PRP cord-023095-4dannjjm 5120 2 hypothesized hypothesize VBD cord-023095-4dannjjm 5120 3 that that IN cord-023095-4dannjjm 5120 4 ATO ATO NNP cord-023095-4dannjjm 5120 5 will will MD cord-023095-4dannjjm 5120 6 re re VB cord-023095-4dannjjm 5120 7 - - VB cord-023095-4dannjjm 5120 8 sensitize sensitize VB cord-023095-4dannjjm 5120 9 glucocorticoid glucocorticoid NN cord-023095-4dannjjm 5120 10 - - HYPH cord-023095-4dannjjm 5120 11 resistant resistant JJ cord-023095-4dannjjm 5120 12 canine canine JJ cord-023095-4dannjjm 5120 13 lymphoma lymphoma NN cord-023095-4dannjjm 5120 14 cells cell NNS cord-023095-4dannjjm 5120 15 to to IN cord-023095-4dannjjm 5120 16 glucocorticoid glucocorticoid NN cord-023095-4dannjjm 5120 17 - - HYPH cord-023095-4dannjjm 5120 18 induced induce VBN cord-023095-4dannjjm 5120 19 apoptotic apoptotic JJ cord-023095-4dannjjm 5120 20 death death NN cord-023095-4dannjjm 5120 21 . . . cord-023095-4dannjjm 5121 1 The the DT cord-023095-4dannjjm 5121 2 OSW OSW NNP cord-023095-4dannjjm 5121 3 canine canine JJ cord-023095-4dannjjm 5121 4 lymphoma lymphoma NN cord-023095-4dannjjm 5121 5 cell cell NN cord-023095-4dannjjm 5121 6 line line NN cord-023095-4dannjjm 5121 7 was be VBD cord-023095-4dannjjm 5121 8 cultured culture VBN cord-023095-4dannjjm 5121 9 with with IN cord-023095-4dannjjm 5121 10 200 200 CD cord-023095-4dannjjm 5121 11 uM um UH cord-023095-4dannjjm 5121 12 dexamethasone dexamethasone NN cord-023095-4dannjjm 5121 13 . . . cord-023095-4dannjjm 5122 1 Remaining remain VBG cord-023095-4dannjjm 5122 2 viable viable JJ cord-023095-4dannjjm 5122 3 dividing dividing NN cord-023095-4dannjjm 5122 4 cells cell NNS cord-023095-4dannjjm 5122 5 were be VBD cord-023095-4dannjjm 5122 6 considered consider VBN cord-023095-4dannjjm 5122 7 resistant resistant JJ cord-023095-4dannjjm 5122 8 . . . cord-023095-4dannjjm 5123 1 Resistant resistant JJ cord-023095-4dannjjm 5123 2 cells cell NNS cord-023095-4dannjjm 5123 3 were be VBD cord-023095-4dannjjm 5123 4 exposed expose VBN cord-023095-4dannjjm 5123 5 to to IN cord-023095-4dannjjm 5123 6 0.01 0.01 CD cord-023095-4dannjjm 5123 7 uM um UH cord-023095-4dannjjm 5123 8 and and CC cord-023095-4dannjjm 5123 9 0.02 0.02 CD cord-023095-4dannjjm 5123 10 uM um UH cord-023095-4dannjjm 5123 11 of of IN cord-023095-4dannjjm 5123 12 ATO ATO NNP cord-023095-4dannjjm 5123 13 without without IN cord-023095-4dannjjm 5123 14 dexamethasone dexamethasone NN cord-023095-4dannjjm 5123 15 , , , cord-023095-4dannjjm 5123 16 after after IN cord-023095-4dannjjm 5123 17 which which WDT cord-023095-4dannjjm 5123 18 cells cell NNS cord-023095-4dannjjm 5123 19 were be VBD cord-023095-4dannjjm 5123 20 washed wash VBN cord-023095-4dannjjm 5123 21 and and CC cord-023095-4dannjjm 5123 22 re re VBN cord-023095-4dannjjm 5123 23 - - VBN cord-023095-4dannjjm 5123 24 exposed expose VBN cord-023095-4dannjjm 5123 25 to to IN cord-023095-4dannjjm 5123 26 200 200 CD cord-023095-4dannjjm 5123 27 uM um UH cord-023095-4dannjjm 5123 28 dexamethasone dexamethasone NN cord-023095-4dannjjm 5123 29 . . . cord-023095-4dannjjm 5124 1 After after IN cord-023095-4dannjjm 5124 2 24 24 CD cord-023095-4dannjjm 5124 3 , , , cord-023095-4dannjjm 5124 4 48 48 CD cord-023095-4dannjjm 5124 5 and and CC cord-023095-4dannjjm 5124 6 72 72 CD cord-023095-4dannjjm 5124 7 hours hour NNS cord-023095-4dannjjm 5124 8 of of IN cord-023095-4dannjjm 5124 9 dexamethasone dexamethasone NN cord-023095-4dannjjm 5124 10 exposure exposure NN cord-023095-4dannjjm 5124 11 , , , cord-023095-4dannjjm 5124 12 cells cell NNS cord-023095-4dannjjm 5124 13 were be VBD cord-023095-4dannjjm 5124 14 counted count VBN cord-023095-4dannjjm 5124 15 using use VBG cord-023095-4dannjjm 5124 16 Trypan Trypan NNP cord-023095-4dannjjm 5124 17 blue blue JJ cord-023095-4dannjjm 5124 18 stain stain NN cord-023095-4dannjjm 5124 19 . . . cord-023095-4dannjjm 5125 1 Apoptosis apoptosis NN cord-023095-4dannjjm 5125 2 was be VBD cord-023095-4dannjjm 5125 3 assessed assess VBN cord-023095-4dannjjm 5125 4 by by IN cord-023095-4dannjjm 5125 5 TUNEL TUNEL NNP cord-023095-4dannjjm 5125 6 assays assay NNS cord-023095-4dannjjm 5125 7 on on IN cord-023095-4dannjjm 5125 8 cytospin cytospin NNP cord-023095-4dannjjm 5125 9 preparations preparation NNS cord-023095-4dannjjm 5125 10 collected collect VBD cord-023095-4dannjjm 5125 11 at at IN cord-023095-4dannjjm 5125 12 24 24 CD cord-023095-4dannjjm 5125 13 , , , cord-023095-4dannjjm 5125 14 48 48 CD cord-023095-4dannjjm 5125 15 , , , cord-023095-4dannjjm 5125 16 and and CC cord-023095-4dannjjm 5125 17 72 72 CD cord-023095-4dannjjm 5125 18 hours hour NNS cord-023095-4dannjjm 5125 19 from from IN cord-023095-4dannjjm 5125 20 ATO ATO NNP cord-023095-4dannjjm 5125 21 - - HYPH cord-023095-4dannjjm 5125 22 exposed expose VBN cord-023095-4dannjjm 5125 23 and and CC cord-023095-4dannjjm 5125 24 control control NN cord-023095-4dannjjm 5125 25 groups group NNS cord-023095-4dannjjm 5125 26 . . . cord-023095-4dannjjm 5126 1 Statistical statistical JJ cord-023095-4dannjjm 5126 2 analysis analysis NN cord-023095-4dannjjm 5126 3 was be VBD cord-023095-4dannjjm 5126 4 performed perform VBN cord-023095-4dannjjm 5126 5 using use VBG cord-023095-4dannjjm 5126 6 1 1 CD cord-023095-4dannjjm 5126 7 way way NN cord-023095-4dannjjm 5126 8 ANOVA ANOVA NNP cord-023095-4dannjjm 5126 9 and and CC cord-023095-4dannjjm 5126 10 Tukey Tukey NNP cord-023095-4dannjjm 5126 11 's 's POS cord-023095-4dannjjm 5126 12 test test NN cord-023095-4dannjjm 5126 13 . . . cord-023095-4dannjjm 5127 1 The the DT cord-023095-4dannjjm 5127 2 proportion proportion NN cord-023095-4dannjjm 5127 3 of of IN cord-023095-4dannjjm 5127 4 dead dead JJ cord-023095-4dannjjm 5127 5 cells cell NNS cord-023095-4dannjjm 5127 6 increased increase VBD cord-023095-4dannjjm 5127 7 over over IN cord-023095-4dannjjm 5127 8 time time NN cord-023095-4dannjjm 5127 9 in in IN cord-023095-4dannjjm 5127 10 both both DT cord-023095-4dannjjm 5127 11 0.01 0.01 CD cord-023095-4dannjjm 5127 12 uM um UH cord-023095-4dannjjm 5127 13 and and CC cord-023095-4dannjjm 5127 14 0.02 0.02 CD cord-023095-4dannjjm 5127 15 uM um UH cord-023095-4dannjjm 5127 16 ATO ATO NNP cord-023095-4dannjjm 5127 17 exposed expose VBD cord-023095-4dannjjm 5127 18 groups group NNS cord-023095-4dannjjm 5127 19 . . . cord-023095-4dannjjm 5128 1 The the DT cord-023095-4dannjjm 5128 2 proportion proportion NN cord-023095-4dannjjm 5128 3 of of IN cord-023095-4dannjjm 5128 4 dead dead JJ cord-023095-4dannjjm 5128 5 cells cell NNS cord-023095-4dannjjm 5128 6 was be VBD cord-023095-4dannjjm 5128 7 greater great JJR cord-023095-4dannjjm 5128 8 for for IN cord-023095-4dannjjm 5128 9 0.01 0.01 CD cord-023095-4dannjjm 5128 10 uM um UH cord-023095-4dannjjm 5128 11 ATO ATO NNP cord-023095-4dannjjm 5128 12 ( ( -LRB- cord-023095-4dannjjm 5128 13 p p NN cord-023095-4dannjjm 5128 14 o o CD cord-023095-4dannjjm 5128 15 0.001 0.001 CD cord-023095-4dannjjm 5128 16 ) ) -RRB- cord-023095-4dannjjm 5128 17 and and CC cord-023095-4dannjjm 5128 18 0.02 0.02 CD cord-023095-4dannjjm 5128 19 uM um UH cord-023095-4dannjjm 5128 20 ( ( -LRB- cord-023095-4dannjjm 5128 21 p p NN cord-023095-4dannjjm 5128 22 o o NN cord-023095-4dannjjm 5128 23 0.001 0.001 CD cord-023095-4dannjjm 5128 24 ) ) -RRB- cord-023095-4dannjjm 5128 25 groups group NNS cord-023095-4dannjjm 5128 26 compared compare VBN cord-023095-4dannjjm 5128 27 to to IN cord-023095-4dannjjm 5128 28 control control NN cord-023095-4dannjjm 5128 29 . . . cord-023095-4dannjjm 5129 1 Apoptosis apoptosis NN cord-023095-4dannjjm 5129 2 increased increase VBD cord-023095-4dannjjm 5129 3 with with IN cord-023095-4dannjjm 5129 4 increasing increase VBG cord-023095-4dannjjm 5129 5 ATO ATO NNP cord-023095-4dannjjm 5129 6 concentration concentration NN cord-023095-4dannjjm 5129 7 and and CC cord-023095-4dannjjm 5129 8 duration duration NN cord-023095-4dannjjm 5129 9 of of IN cord-023095-4dannjjm 5129 10 dexamethasone dexamethasone NN cord-023095-4dannjjm 5129 11 exposure exposure NN cord-023095-4dannjjm 5129 12 compared compare VBN cord-023095-4dannjjm 5129 13 to to IN cord-023095-4dannjjm 5129 14 control control NN cord-023095-4dannjjm 5129 15 . . . cord-023095-4dannjjm 5130 1 These these DT cord-023095-4dannjjm 5130 2 results result NNS cord-023095-4dannjjm 5130 3 support support VBP cord-023095-4dannjjm 5130 4 the the DT cord-023095-4dannjjm 5130 5 effectiveness effectiveness NN cord-023095-4dannjjm 5130 6 of of IN cord-023095-4dannjjm 5130 7 ATO ATO NNP cord-023095-4dannjjm 5130 8 at at IN cord-023095-4dannjjm 5130 9 re re NN cord-023095-4dannjjm 5130 10 - - JJ cord-023095-4dannjjm 5130 11 sensitizing sensitize VBG cord-023095-4dannjjm 5130 12 glucocorticoid glucocorticoid NN cord-023095-4dannjjm 5130 13 - - HYPH cord-023095-4dannjjm 5130 14 resistant resistant JJ cord-023095-4dannjjm 5130 15 canine canine JJ cord-023095-4dannjjm 5130 16 lymphoma lymphoma NN cord-023095-4dannjjm 5130 17 cells cell NNS cord-023095-4dannjjm 5130 18 to to IN cord-023095-4dannjjm 5130 19 apoptotic apoptotic JJ cord-023095-4dannjjm 5130 20 death death NN cord-023095-4dannjjm 5130 21 following follow VBG cord-023095-4dannjjm 5130 22 re re NN cord-023095-4dannjjm 5130 23 - - NN cord-023095-4dannjjm 5130 24 exposure exposure NN cord-023095-4dannjjm 5130 25 to to IN cord-023095-4dannjjm 5130 26 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 5130 27 . . . cord-023095-4dannjjm 5131 1 Ongoing ongoing JJ cord-023095-4dannjjm 5131 2 gene gene NN cord-023095-4dannjjm 5131 3 expression expression NN cord-023095-4dannjjm 5131 4 studies study NNS cord-023095-4dannjjm 5131 5 aim aim VBP cord-023095-4dannjjm 5131 6 to to TO cord-023095-4dannjjm 5131 7 elucidate elucidate VB cord-023095-4dannjjm 5131 8 this this DT cord-023095-4dannjjm 5131 9 mechanism mechanism NN cord-023095-4dannjjm 5131 10 . . . cord-023095-4dannjjm 5132 1 Additional additional JJ cord-023095-4dannjjm 5132 2 studies study NNS cord-023095-4dannjjm 5132 3 to to TO cord-023095-4dannjjm 5132 4 determine determine VB cord-023095-4dannjjm 5132 5 if if IN cord-023095-4dannjjm 5132 6 this this DT cord-023095-4dannjjm 5132 7 effect effect NN cord-023095-4dannjjm 5132 8 is be VBZ cord-023095-4dannjjm 5132 9 seen see VBN cord-023095-4dannjjm 5132 10 with with IN cord-023095-4dannjjm 5132 11 other other JJ cord-023095-4dannjjm 5132 12 chemotherapeutic chemotherapeutic JJ cord-023095-4dannjjm 5132 13 agents agent NNS cord-023095-4dannjjm 5132 14 are be VBP cord-023095-4dannjjm 5132 15 warranted warrant VBN cord-023095-4dannjjm 5132 16 . . . cord-023095-4dannjjm 5133 1 Lymphoma Lymphoma NNP cord-023095-4dannjjm 5133 2 is be VBZ cord-023095-4dannjjm 5133 3 the the DT cord-023095-4dannjjm 5133 4 most most RBS cord-023095-4dannjjm 5133 5 common common JJ cord-023095-4dannjjm 5133 6 hematopoietic hematopoietic JJ cord-023095-4dannjjm 5133 7 tumor tumor NN cord-023095-4dannjjm 5133 8 of of IN cord-023095-4dannjjm 5133 9 dogs dog NNS cord-023095-4dannjjm 5133 10 . . . cord-023095-4dannjjm 5134 1 Protein protein NN cord-023095-4dannjjm 5134 2 disturbances disturbance NNS cord-023095-4dannjjm 5134 3 may may MD cord-023095-4dannjjm 5134 4 be be VB cord-023095-4dannjjm 5134 5 associated associate VBN cord-023095-4dannjjm 5134 6 with with IN cord-023095-4dannjjm 5134 7 this this DT cord-023095-4dannjjm 5134 8 disease disease NN cord-023095-4dannjjm 5134 9 including include VBG cord-023095-4dannjjm 5134 10 monoclonal monoclonal JJ cord-023095-4dannjjm 5134 11 gammopathies gammopathy NNS cord-023095-4dannjjm 5134 12 in in IN cord-023095-4dannjjm 5134 13 a a DT cord-023095-4dannjjm 5134 14 low low JJ cord-023095-4dannjjm 5134 15 percentage percentage NN cord-023095-4dannjjm 5134 16 of of IN cord-023095-4dannjjm 5134 17 cases case NNS cord-023095-4dannjjm 5134 18 . . . cord-023095-4dannjjm 5135 1 Serum serum NN cord-023095-4dannjjm 5135 2 protein protein NN cord-023095-4dannjjm 5135 3 electrophoresis electrophoresis NN cord-023095-4dannjjm 5135 4 ( ( -LRB- cord-023095-4dannjjm 5135 5 SPE SPE NNP cord-023095-4dannjjm 5135 6 ) ) -RRB- cord-023095-4dannjjm 5135 7 is be VBZ cord-023095-4dannjjm 5135 8 routinely routinely RB cord-023095-4dannjjm 5135 9 used use VBN cord-023095-4dannjjm 5135 10 to to TO cord-023095-4dannjjm 5135 11 aid aid VB cord-023095-4dannjjm 5135 12 diagnosis diagnosis NN cord-023095-4dannjjm 5135 13 of of IN cord-023095-4dannjjm 5135 14 various various JJ cord-023095-4dannjjm 5135 15 canine canine JJ cord-023095-4dannjjm 5135 16 diseases disease NNS cord-023095-4dannjjm 5135 17 including include VBG cord-023095-4dannjjm 5135 18 lymphoma lymphoma NN cord-023095-4dannjjm 5135 19 when when WRB cord-023095-4dannjjm 5135 20 total total JJ cord-023095-4dannjjm 5135 21 protein protein NN cord-023095-4dannjjm 5135 22 concentration concentration NN cord-023095-4dannjjm 5135 23 is be VBZ cord-023095-4dannjjm 5135 24 elevated elevate VBN cord-023095-4dannjjm 5135 25 . . . cord-023095-4dannjjm 5136 1 The the DT cord-023095-4dannjjm 5136 2 purpose purpose NN cord-023095-4dannjjm 5136 3 of of IN cord-023095-4dannjjm 5136 4 this this DT cord-023095-4dannjjm 5136 5 study study NN cord-023095-4dannjjm 5136 6 was be VBD cord-023095-4dannjjm 5136 7 to to TO cord-023095-4dannjjm 5136 8 compare compare VB cord-023095-4dannjjm 5136 9 SPE SPE NNP cord-023095-4dannjjm 5136 10 changes change NNS cord-023095-4dannjjm 5136 11 in in IN cord-023095-4dannjjm 5136 12 lymphoma lymphoma NN cord-023095-4dannjjm 5136 13 patients patient NNS cord-023095-4dannjjm 5136 14 without without IN cord-023095-4dannjjm 5136 15 elevated elevated JJ cord-023095-4dannjjm 5136 16 total total JJ cord-023095-4dannjjm 5136 17 proteins protein NNS cord-023095-4dannjjm 5136 18 with with IN cord-023095-4dannjjm 5136 19 a a DT cord-023095-4dannjjm 5136 20 population population NN cord-023095-4dannjjm 5136 21 of of IN cord-023095-4dannjjm 5136 22 healthy healthy JJ cord-023095-4dannjjm 5136 23 dogs dog NNS cord-023095-4dannjjm 5136 24 . . . cord-023095-4dannjjm 5137 1 Agarose Agarose NNP cord-023095-4dannjjm 5137 2 gel gel NN cord-023095-4dannjjm 5137 3 electrophoresis electrophoresis NN cord-023095-4dannjjm 5137 4 was be VBD cord-023095-4dannjjm 5137 5 performed perform VBN cord-023095-4dannjjm 5137 6 on on IN cord-023095-4dannjjm 5137 7 residual residual JJ cord-023095-4dannjjm 5137 8 serum serum NN cord-023095-4dannjjm 5137 9 from from IN cord-023095-4dannjjm 5137 10 17 17 CD cord-023095-4dannjjm 5137 11 healthy healthy JJ cord-023095-4dannjjm 5137 12 control control NN cord-023095-4dannjjm 5137 13 dogs dog NNS cord-023095-4dannjjm 5137 14 and and CC cord-023095-4dannjjm 5137 15 21 21 CD cord-023095-4dannjjm 5137 16 untreated untreated JJ cord-023095-4dannjjm 5137 17 dogs dog NNS cord-023095-4dannjjm 5137 18 with with IN cord-023095-4dannjjm 5137 19 multicentric multicentric JJ cord-023095-4dannjjm 5137 20 lymphoma lymphoma NN cord-023095-4dannjjm 5137 21 ( ( -LRB- cord-023095-4dannjjm 5137 22 stage stage NN cord-023095-4dannjjm 5137 23 III III NNP cord-023095-4dannjjm 5137 24 -V -V NFP cord-023095-4dannjjm 5137 25 ) ) -RRB- cord-023095-4dannjjm 5137 26 after after IN cord-023095-4dannjjm 5137 27 measuring measure VBG cord-023095-4dannjjm 5137 28 total total JJ cord-023095-4dannjjm 5137 29 protein protein NN cord-023095-4dannjjm 5137 30 ( ( -LRB- cord-023095-4dannjjm 5137 31 TP TP NNP cord-023095-4dannjjm 5137 32 ) ) -RRB- cord-023095-4dannjjm 5137 33 using use VBG cord-023095-4dannjjm 5137 34 the the DT cord-023095-4dannjjm 5137 35 biuret biuret NN cord-023095-4dannjjm 5137 36 method method NN cord-023095-4dannjjm 5137 37 . . . cord-023095-4dannjjm 5138 1 Densitometric Densitometric NNP cord-023095-4dannjjm 5138 2 traces trace NNS cord-023095-4dannjjm 5138 3 of of IN cord-023095-4dannjjm 5138 4 the the DT cord-023095-4dannjjm 5138 5 protein protein NN cord-023095-4dannjjm 5138 6 bands band NNS cord-023095-4dannjjm 5138 7 were be VBD cord-023095-4dannjjm 5138 8 obtained obtain VBN cord-023095-4dannjjm 5138 9 using use VBG cord-023095-4dannjjm 5138 10 computer computer NN cord-023095-4dannjjm 5138 11 software software NN cord-023095-4dannjjm 5138 12 ( ( -LRB- cord-023095-4dannjjm 5138 13 Totallab Totallab NNP cord-023095-4dannjjm 5138 14 100 100 CD cord-023095-4dannjjm 5138 15 ) ) -RRB- cord-023095-4dannjjm 5138 16 and and CC cord-023095-4dannjjm 5138 17 the the DT cord-023095-4dannjjm 5138 18 albumin albumin NN cord-023095-4dannjjm 5138 19 , , , cord-023095-4dannjjm 5138 20 alpha-1 alpha-1 NNP cord-023095-4dannjjm 5138 21 , , , cord-023095-4dannjjm 5138 22 alpha-2 alpha-2 NN cord-023095-4dannjjm 5138 23 , , , cord-023095-4dannjjm 5138 24 beta-2 beta-2 NN cord-023095-4dannjjm 5138 25 and and CC cord-023095-4dannjjm 5138 26 gamma gamma NN cord-023095-4dannjjm 5138 27 globulin globulin NN cord-023095-4dannjjm 5138 28 subfractions subfraction NNS cord-023095-4dannjjm 5138 29 were be VBD cord-023095-4dannjjm 5138 30 identified identify VBN cord-023095-4dannjjm 5138 31 by by IN cord-023095-4dannjjm 5138 32 visual visual JJ cord-023095-4dannjjm 5138 33 inspection inspection NN cord-023095-4dannjjm 5138 34 . . . cord-023095-4dannjjm 5139 1 The the DT cord-023095-4dannjjm 5139 2 total total JJ cord-023095-4dannjjm 5139 3 protein protein NN cord-023095-4dannjjm 5139 4 concentration concentration NN cord-023095-4dannjjm 5139 5 , , , cord-023095-4dannjjm 5139 6 the the DT cord-023095-4dannjjm 5139 7 number number NN cord-023095-4dannjjm 5139 8 of of IN cord-023095-4dannjjm 5139 9 subfractions subfraction NNS cord-023095-4dannjjm 5139 10 and and CC cord-023095-4dannjjm 5139 11 the the DT cord-023095-4dannjjm 5139 12 relative relative JJ cord-023095-4dannjjm 5139 13 and and CC cord-023095-4dannjjm 5139 14 absolute absolute JJ cord-023095-4dannjjm 5139 15 protein protein NN cord-023095-4dannjjm 5139 16 subfraction subfraction NN cord-023095-4dannjjm 5139 17 concentrations concentration NNS cord-023095-4dannjjm 5139 18 were be VBD cord-023095-4dannjjm 5139 19 then then RB cord-023095-4dannjjm 5139 20 compared compare VBN cord-023095-4dannjjm 5139 21 statistically statistically RB cord-023095-4dannjjm 5139 22 between between IN cord-023095-4dannjjm 5139 23 the the DT cord-023095-4dannjjm 5139 24 two two CD cord-023095-4dannjjm 5139 25 populations population NNS cord-023095-4dannjjm 5139 26 . . . cord-023095-4dannjjm 5140 1 In in IN cord-023095-4dannjjm 5140 2 lymphoma lymphoma NN cord-023095-4dannjjm 5140 3 dogs dog NNS cord-023095-4dannjjm 5140 4 , , , cord-023095-4dannjjm 5140 5 TP tp NN cord-023095-4dannjjm 5140 6 , , , cord-023095-4dannjjm 5140 7 absolute absolute JJ cord-023095-4dannjjm 5140 8 albumin albumin NN cord-023095-4dannjjm 5140 9 , , , cord-023095-4dannjjm 5140 10 beta-2 beta-2 NN cord-023095-4dannjjm 5140 11 and and CC cord-023095-4dannjjm 5140 12 gamma gamma NN cord-023095-4dannjjm 5140 13 globulin globulin NN cord-023095-4dannjjm 5140 14 concentrations concentration NNS cord-023095-4dannjjm 5140 15 and and CC cord-023095-4dannjjm 5140 16 both both CC cord-023095-4dannjjm 5140 17 relative relative JJ cord-023095-4dannjjm 5140 18 and and CC cord-023095-4dannjjm 5140 19 absolute absolute JJ cord-023095-4dannjjm 5140 20 concentrations concentration NNS cord-023095-4dannjjm 5140 21 of of IN cord-023095-4dannjjm 5140 22 the the DT cord-023095-4dannjjm 5140 23 alpha-1 alpha-1 NNP cord-023095-4dannjjm 5140 24 globulins globulin NNS cord-023095-4dannjjm 5140 25 were be VBD cord-023095-4dannjjm 5140 26 significantly significantly RB cord-023095-4dannjjm 5140 27 lower low JJR cord-023095-4dannjjm 5140 28 however however RB cord-023095-4dannjjm 5140 29 relative relative JJ cord-023095-4dannjjm 5140 30 and and CC cord-023095-4dannjjm 5140 31 absolute absolute JJ cord-023095-4dannjjm 5140 32 alpha-2 alpha-2 NN cord-023095-4dannjjm 5140 33 globulin globulin NN cord-023095-4dannjjm 5140 34 concentrations concentration NNS cord-023095-4dannjjm 5140 35 were be VBD cord-023095-4dannjjm 5140 36 significantly significantly RB cord-023095-4dannjjm 5140 37 elevated elevate VBN cord-023095-4dannjjm 5140 38 . . . cord-023095-4dannjjm 5141 1 No no DT cord-023095-4dannjjm 5141 2 monoclonal monoclonal JJ cord-023095-4dannjjm 5141 3 gammopathies gammopathy NNS cord-023095-4dannjjm 5141 4 were be VBD cord-023095-4dannjjm 5141 5 identified identify VBN cord-023095-4dannjjm 5141 6 in in IN cord-023095-4dannjjm 5141 7 any any DT cord-023095-4dannjjm 5141 8 of of IN cord-023095-4dannjjm 5141 9 the the DT cord-023095-4dannjjm 5141 10 dogs dog NNS cord-023095-4dannjjm 5141 11 and and CC cord-023095-4dannjjm 5142 1 not not RB cord-023095-4dannjjm 5142 2 every every DT cord-023095-4dannjjm 5142 3 patient patient NN cord-023095-4dannjjm 5142 4 with with IN cord-023095-4dannjjm 5142 5 lymphoma lymphoma NN cord-023095-4dannjjm 5142 6 had have VBD cord-023095-4dannjjm 5142 7 the the DT cord-023095-4dannjjm 5142 8 above above JJ cord-023095-4dannjjm 5142 9 changes change NNS cord-023095-4dannjjm 5142 10 in in IN cord-023095-4dannjjm 5142 11 their -PRON- PRP$ cord-023095-4dannjjm 5142 12 electrophoretogram electrophoretogram NN cord-023095-4dannjjm 5142 13 . . . cord-023095-4dannjjm 5143 1 This this DT cord-023095-4dannjjm 5143 2 study study NN cord-023095-4dannjjm 5143 3 has have VBZ cord-023095-4dannjjm 5143 4 demonstrated demonstrate VBN cord-023095-4dannjjm 5143 5 that that IN cord-023095-4dannjjm 5143 6 significant significant JJ cord-023095-4dannjjm 5143 7 changes change NNS cord-023095-4dannjjm 5143 8 occur occur VBP cord-023095-4dannjjm 5143 9 in in IN cord-023095-4dannjjm 5143 10 the the DT cord-023095-4dannjjm 5143 11 albumin albumin NN cord-023095-4dannjjm 5143 12 and and CC cord-023095-4dannjjm 5143 13 globulin globulin NN cord-023095-4dannjjm 5143 14 fractions fraction NNS cord-023095-4dannjjm 5143 15 of of IN cord-023095-4dannjjm 5143 16 canine canine JJ cord-023095-4dannjjm 5143 17 lymphoma lymphoma NN cord-023095-4dannjjm 5143 18 patients patient NNS cord-023095-4dannjjm 5143 19 despite despite IN cord-023095-4dannjjm 5143 20 no no DT cord-023095-4dannjjm 5143 21 obvious obvious JJ cord-023095-4dannjjm 5143 22 increase increase NN cord-023095-4dannjjm 5143 23 in in IN cord-023095-4dannjjm 5143 24 TP TP NNP cord-023095-4dannjjm 5143 25 . . . cord-023095-4dannjjm 5144 1 Further further JJ cord-023095-4dannjjm 5144 2 investigation investigation NN cord-023095-4dannjjm 5144 3 is be VBZ cord-023095-4dannjjm 5144 4 required require VBN cord-023095-4dannjjm 5144 5 to to TO cord-023095-4dannjjm 5144 6 identify identify VB cord-023095-4dannjjm 5144 7 the the DT cord-023095-4dannjjm 5144 8 proteins protein NNS cord-023095-4dannjjm 5144 9 responsible responsible JJ cord-023095-4dannjjm 5144 10 for for IN cord-023095-4dannjjm 5144 11 these these DT cord-023095-4dannjjm 5144 12 changes change NNS cord-023095-4dannjjm 5144 13 . . . cord-023095-4dannjjm 5145 1 It -PRON- PRP cord-023095-4dannjjm 5145 2 is be VBZ cord-023095-4dannjjm 5145 3 well well RB cord-023095-4dannjjm 5145 4 known know VBN cord-023095-4dannjjm 5145 5 that that IN cord-023095-4dannjjm 5145 6 immunophenotype immunophenotype NN cord-023095-4dannjjm 5145 7 has have VBZ cord-023095-4dannjjm 5145 8 a a DT cord-023095-4dannjjm 5145 9 prognostic prognostic JJ cord-023095-4dannjjm 5145 10 value value NN cord-023095-4dannjjm 5145 11 for for IN cord-023095-4dannjjm 5145 12 the the DT cord-023095-4dannjjm 5145 13 outcome outcome NN cord-023095-4dannjjm 5145 14 of of IN cord-023095-4dannjjm 5145 15 canine canine JJ cord-023095-4dannjjm 5145 16 lymphoma lymphoma NN cord-023095-4dannjjm 5145 17 , , , cord-023095-4dannjjm 5145 18 with with IN cord-023095-4dannjjm 5145 19 T t NN cord-023095-4dannjjm 5145 20 - - HYPH cord-023095-4dannjjm 5145 21 cell cell NN cord-023095-4dannjjm 5145 22 lymphomas lymphoma NNS cord-023095-4dannjjm 5145 23 having have VBG cord-023095-4dannjjm 5145 24 a a DT cord-023095-4dannjjm 5145 25 worse bad JJR cord-023095-4dannjjm 5145 26 prognosis prognosis NN cord-023095-4dannjjm 5145 27 than than IN cord-023095-4dannjjm 5145 28 B b NN cord-023095-4dannjjm 5145 29 - - HYPH cord-023095-4dannjjm 5145 30 cell cell NN cord-023095-4dannjjm 5145 31 lymphomas lymphoma NNS cord-023095-4dannjjm 5145 32 . . . cord-023095-4dannjjm 5146 1 The the DT cord-023095-4dannjjm 5146 2 recent recent JJ cord-023095-4dannjjm 5146 3 advent advent NN cord-023095-4dannjjm 5146 4 of of IN cord-023095-4dannjjm 5146 5 flowcytometric flowcytometric JJ cord-023095-4dannjjm 5146 6 techniques technique NNS cord-023095-4dannjjm 5146 7 allowed allow VBD cord-023095-4dannjjm 5146 8 easy easy JJ cord-023095-4dannjjm 5146 9 detection detection NN cord-023095-4dannjjm 5146 10 of of IN cord-023095-4dannjjm 5146 11 many many JJ cord-023095-4dannjjm 5146 12 different different JJ cord-023095-4dannjjm 5146 13 markers marker NNS cord-023095-4dannjjm 5146 14 on on IN cord-023095-4dannjjm 5146 15 lymphoma lymphoma NN cord-023095-4dannjjm 5146 16 cells cell NNS cord-023095-4dannjjm 5146 17 and and CC cord-023095-4dannjjm 5146 18 therefore therefore RB cord-023095-4dannjjm 5146 19 , , , cord-023095-4dannjjm 5146 20 not not RB cord-023095-4dannjjm 5146 21 only only RB cord-023095-4dannjjm 5146 22 distinguish distinguish VB cord-023095-4dannjjm 5146 23 between between IN cord-023095-4dannjjm 5146 24 T t NN cord-023095-4dannjjm 5146 25 and and CC cord-023095-4dannjjm 5146 26 B b NN cord-023095-4dannjjm 5146 27 cells cell NNS cord-023095-4dannjjm 5146 28 , , , cord-023095-4dannjjm 5146 29 but but CC cord-023095-4dannjjm 5146 30 also also RB cord-023095-4dannjjm 5146 31 estimate estimate VBP cord-023095-4dannjjm 5146 32 possible possible JJ cord-023095-4dannjjm 5146 33 aberration aberration NN cord-023095-4dannjjm 5146 34 on on IN cord-023095-4dannjjm 5146 35 immunophenotype immunophenotype NN cord-023095-4dannjjm 5146 36 . . . cord-023095-4dannjjm 5147 1 In in IN cord-023095-4dannjjm 5147 2 human human JJ cord-023095-4dannjjm 5147 3 oncology oncology NN cord-023095-4dannjjm 5147 4 , , , cord-023095-4dannjjm 5147 5 although although IN cord-023095-4dannjjm 5147 6 some some DT cord-023095-4dannjjm 5147 7 controversy controversy NN cord-023095-4dannjjm 5147 8 persists persist VBZ cord-023095-4dannjjm 5147 9 , , , cord-023095-4dannjjm 5147 10 it -PRON- PRP cord-023095-4dannjjm 5147 11 seems seem VBZ cord-023095-4dannjjm 5147 12 that that IN cord-023095-4dannjjm 5147 13 non non JJ cord-023095-4dannjjm 5147 14 - - JJ cord-023095-4dannjjm 5147 15 Hodgkins hodgkins JJ cord-023095-4dannjjm 5147 16 lymphoma lymphoma NN cord-023095-4dannjjm 5147 17 and and CC cord-023095-4dannjjm 5147 18 acute acute JJ cord-023095-4dannjjm 5147 19 leukemia leukemia NN cord-023095-4dannjjm 5147 20 carrying carry VBG cord-023095-4dannjjm 5147 21 aberrations aberration NNS cord-023095-4dannjjm 5147 22 have have VBP cord-023095-4dannjjm 5147 23 a a DT cord-023095-4dannjjm 5147 24 worse bad JJR cord-023095-4dannjjm 5147 25 prognosis prognosis NN cord-023095-4dannjjm 5147 26 . . . cord-023095-4dannjjm 5148 1 The the DT cord-023095-4dannjjm 5148 2 aim aim NN cord-023095-4dannjjm 5148 3 of of IN cord-023095-4dannjjm 5148 4 this this DT cord-023095-4dannjjm 5148 5 study study NN cord-023095-4dannjjm 5148 6 was be VBD cord-023095-4dannjjm 5148 7 to to TO cord-023095-4dannjjm 5148 8 evaluate evaluate VB cord-023095-4dannjjm 5148 9 the the DT cord-023095-4dannjjm 5148 10 role role NN cord-023095-4dannjjm 5148 11 of of IN cord-023095-4dannjjm 5148 12 immunophenotype immunophenotype NN cord-023095-4dannjjm 5148 13 aberration aberration NN cord-023095-4dannjjm 5148 14 in in IN cord-023095-4dannjjm 5148 15 canine canine JJ cord-023095-4dannjjm 5148 16 high high JJ cord-023095-4dannjjm 5148 17 - - HYPH cord-023095-4dannjjm 5148 18 grade grade NN cord-023095-4dannjjm 5148 19 lymphoma lymphoma NN cord-023095-4dannjjm 5148 20 considering consider VBG cord-023095-4dannjjm 5148 21 outcome outcome NN cord-023095-4dannjjm 5148 22 and and CC cord-023095-4dannjjm 5148 23 time time NN cord-023095-4dannjjm 5148 24 span span NN cord-023095-4dannjjm 5148 25 to to TO cord-023095-4dannjjm 5148 26 achieve achieve VB cord-023095-4dannjjm 5148 27 complete complete JJ cord-023095-4dannjjm 5148 28 response response NN cord-023095-4dannjjm 5148 29 under under IN cord-023095-4dannjjm 5148 30 chemotherapy chemotherapy NN cord-023095-4dannjjm 5148 31 . . . cord-023095-4dannjjm 5149 1 Samples sample NNS cord-023095-4dannjjm 5149 2 of of IN cord-023095-4dannjjm 5149 3 bone bone NN cord-023095-4dannjjm 5149 4 marrow marrow NN cord-023095-4dannjjm 5149 5 , , , cord-023095-4dannjjm 5149 6 blood blood NN cord-023095-4dannjjm 5149 7 and and CC cord-023095-4dannjjm 5149 8 lymph lymph NN cord-023095-4dannjjm 5149 9 node node NN cord-023095-4dannjjm 5149 10 suspensions suspension NNS cord-023095-4dannjjm 5149 11 from from IN cord-023095-4dannjjm 5149 12 twentythree twentythree NNP cord-023095-4dannjjm 5149 13 dogs dog NNS cord-023095-4dannjjm 5149 14 were be VBD cord-023095-4dannjjm 5149 15 evaluated evaluate VBN cord-023095-4dannjjm 5149 16 with with IN cord-023095-4dannjjm 5149 17 flow flow NN cord-023095-4dannjjm 5149 18 - - HYPH cord-023095-4dannjjm 5149 19 cytometry cytometry NN cord-023095-4dannjjm 5149 20 . . . cord-023095-4dannjjm 5150 1 Eleven eleven CD cord-023095-4dannjjm 5150 2 dogs dog NNS cord-023095-4dannjjm 5150 3 had have VBD cord-023095-4dannjjm 5150 4 aberrant aberrant JJ cord-023095-4dannjjm 5150 5 expression expression NN cord-023095-4dannjjm 5150 6 of of IN cord-023095-4dannjjm 5150 7 neoplastic neoplastic JJ cord-023095-4dannjjm 5150 8 lymphocytes lymphocyte NNS cord-023095-4dannjjm 5150 9 and and CC cord-023095-4dannjjm 5150 10 twelve twelve CD cord-023095-4dannjjm 5150 11 were be VBD cord-023095-4dannjjm 5150 12 non non JJ cord-023095-4dannjjm 5150 13 - - JJ cord-023095-4dannjjm 5150 14 aberrant aberrant JJ cord-023095-4dannjjm 5150 15 . . . cord-023095-4dannjjm 5151 1 The the DT cord-023095-4dannjjm 5151 2 most most RBS cord-023095-4dannjjm 5151 3 common common JJ cord-023095-4dannjjm 5151 4 aberrations aberration NNS cord-023095-4dannjjm 5151 5 found find VBN cord-023095-4dannjjm 5151 6 were be VBD cord-023095-4dannjjm 5151 7 : : : cord-023095-4dannjjm 5151 8 positivity positivity NN cord-023095-4dannjjm 5151 9 to to IN cord-023095-4dannjjm 5151 10 CD34 CD34 NNP cord-023095-4dannjjm 5151 11 , , , cord-023095-4dannjjm 5151 12 biphenotypes biphenotype NNS cord-023095-4dannjjm 5151 13 , , , cord-023095-4dannjjm 5151 14 double double JJ cord-023095-4dannjjm 5151 15 expression expression NN cord-023095-4dannjjm 5151 16 of of IN cord-023095-4dannjjm 5151 17 Tantigens Tantigens NNP cord-023095-4dannjjm 5151 18 ( ( -LRB- cord-023095-4dannjjm 5151 19 CD41 CD41 NNP cord-023095-4dannjjm 5151 20 , , , cord-023095-4dannjjm 5151 21 CD81 CD81 NNP cord-023095-4dannjjm 5151 22 ) ) -RRB- cord-023095-4dannjjm 5151 23 , , , cord-023095-4dannjjm 5151 24 diminished diminish VBD cord-023095-4dannjjm 5151 25 expression expression NN cord-023095-4dannjjm 5151 26 of of IN cord-023095-4dannjjm 5151 27 CD45 CD45 NNP cord-023095-4dannjjm 5151 28 . . . cord-023095-4dannjjm 5152 1 All all DT cord-023095-4dannjjm 5152 2 dogs dog NNS cord-023095-4dannjjm 5152 3 were be VBD cord-023095-4dannjjm 5152 4 treated treat VBN cord-023095-4dannjjm 5152 5 with with IN cord-023095-4dannjjm 5152 6 a a DT cord-023095-4dannjjm 5152 7 CHOP chop NN cord-023095-4dannjjm 5152 8 - - HYPH cord-023095-4dannjjm 5152 9 based base VBN cord-023095-4dannjjm 5152 10 protocol protocol NN cord-023095-4dannjjm 5152 11 . . . cord-023095-4dannjjm 5153 1 There there EX cord-023095-4dannjjm 5153 2 was be VBD cord-023095-4dannjjm 5153 3 a a DT cord-023095-4dannjjm 5153 4 significant significant JJ cord-023095-4dannjjm 5153 5 difference difference NN cord-023095-4dannjjm 5153 6 for for IN cord-023095-4dannjjm 5153 7 the the DT cord-023095-4dannjjm 5153 8 time time NN cord-023095-4dannjjm 5153 9 to to TO cord-023095-4dannjjm 5153 10 achieve achieve VB cord-023095-4dannjjm 5153 11 response response NN cord-023095-4dannjjm 5153 12 to to IN cord-023095-4dannjjm 5153 13 chemotherapy chemotherapy NN cord-023095-4dannjjm 5153 14 ( ( -LRB- cord-023095-4dannjjm 5153 15 partial partial JJ cord-023095-4dannjjm 5153 16 or or CC cord-023095-4dannjjm 5153 17 complete complete JJ cord-023095-4dannjjm 5153 18 ) ) -RRB- cord-023095-4dannjjm 5153 19 . . . cord-023095-4dannjjm 5154 1 12/12 12/12 CD cord-023095-4dannjjm 5154 2 non non JJ cord-023095-4dannjjm 5154 3 aberrant aberrant JJ cord-023095-4dannjjm 5154 4 lymphomas lymphoma NNS cord-023095-4dannjjm 5154 5 went go VBD cord-023095-4dannjjm 5154 6 into into IN cord-023095-4dannjjm 5154 7 CR CR NNP cord-023095-4dannjjm 5154 8 or or CC cord-023095-4dannjjm 5154 9 PR PR NNP cord-023095-4dannjjm 5154 10 after after IN cord-023095-4dannjjm 5154 11 the the DT cord-023095-4dannjjm 5154 12 first first JJ cord-023095-4dannjjm 5154 13 treatment treatment NN cord-023095-4dannjjm 5154 14 ( ( -LRB- cord-023095-4dannjjm 5154 15 L l NN cord-023095-4dannjjm 5154 16 - - HYPH cord-023095-4dannjjm 5154 17 Asparaginase Asparaginase NNP cord-023095-4dannjjm 5154 18 ) ) -RRB- cord-023095-4dannjjm 5154 19 , , , cord-023095-4dannjjm 5154 20 while while IN cord-023095-4dannjjm 5154 21 aberrant aberrant JJ cord-023095-4dannjjm 5154 22 lympho lympho NNP cord-023095-4dannjjm 5154 23 - - HYPH cord-023095-4dannjjm 5154 24 mas mas NNP cord-023095-4dannjjm 5154 25 needed need VBD cord-023095-4dannjjm 5154 26 more more JJR cord-023095-4dannjjm 5154 27 than than IN cord-023095-4dannjjm 5154 28 2 2 CD cord-023095-4dannjjm 5154 29 treatment treatment NN cord-023095-4dannjjm 5154 30 to to TO cord-023095-4dannjjm 5154 31 reach reach VB cord-023095-4dannjjm 5154 32 CR CR NNP cord-023095-4dannjjm 5154 33 or or CC cord-023095-4dannjjm 5154 34 PR pr NN cord-023095-4dannjjm 5154 35 . . . cord-023095-4dannjjm 5155 1 There there EX cord-023095-4dannjjm 5155 2 was be VBD cord-023095-4dannjjm 5155 3 a a DT cord-023095-4dannjjm 5155 4 trend trend NN cord-023095-4dannjjm 5155 5 for for IN cord-023095-4dannjjm 5155 6 a a DT cord-023095-4dannjjm 5155 7 prolonged prolonged JJ cord-023095-4dannjjm 5155 8 disease disease NN cord-023095-4dannjjm 5155 9 free free JJ cord-023095-4dannjjm 5155 10 interval interval NN cord-023095-4dannjjm 5155 11 with with IN cord-023095-4dannjjm 5155 12 non non JJ cord-023095-4dannjjm 5155 13 - - JJ cord-023095-4dannjjm 5155 14 aberrant aberrant JJ cord-023095-4dannjjm 5155 15 versus versus IN cord-023095-4dannjjm 5155 16 aberrant aberrant JJ cord-023095-4dannjjm 5155 17 , , , cord-023095-4dannjjm 5155 18 although although IN cord-023095-4dannjjm 5155 19 it -PRON- PRP cord-023095-4dannjjm 5155 20 was be VBD cord-023095-4dannjjm 5155 21 not not RB cord-023095-4dannjjm 5155 22 statistically statistically RB cord-023095-4dannjjm 5155 23 significant significant JJ cord-023095-4dannjjm 5155 24 . . . cord-023095-4dannjjm 5156 1 Aberration aberration NN cord-023095-4dannjjm 5156 2 of of IN cord-023095-4dannjjm 5156 3 immunophenotype immunophenotype NN cord-023095-4dannjjm 5156 4 may may MD cord-023095-4dannjjm 5156 5 be be VB cord-023095-4dannjjm 5156 6 a a DT cord-023095-4dannjjm 5156 7 prognostic prognostic JJ cord-023095-4dannjjm 5156 8 factor factor NN cord-023095-4dannjjm 5156 9 for for IN cord-023095-4dannjjm 5156 10 canine canine JJ cord-023095-4dannjjm 5156 11 lymphomas lymphoma NNS cord-023095-4dannjjm 5156 12 , , , cord-023095-4dannjjm 5156 13 but but CC cord-023095-4dannjjm 5156 14 further further JJ cord-023095-4dannjjm 5156 15 studies study NNS cord-023095-4dannjjm 5156 16 with with IN cord-023095-4dannjjm 5156 17 larger large JJR cord-023095-4dannjjm 5156 18 groups group NNS cord-023095-4dannjjm 5156 19 are be VBP cord-023095-4dannjjm 5156 20 needed need VBN cord-023095-4dannjjm 5156 21 . . . cord-023095-4dannjjm 5157 1 Class Class NNP cord-023095-4dannjjm 5157 2 II II NNP cord-023095-4dannjjm 5157 3 major major JJ cord-023095-4dannjjm 5157 4 histocompatibility histocompatibility NN cord-023095-4dannjjm 5157 5 expression expression NN cord-023095-4dannjjm 5157 6 is be VBZ cord-023095-4dannjjm 5157 7 a a DT cord-023095-4dannjjm 5157 8 significant significant JJ cord-023095-4dannjjm 5157 9 and and CC cord-023095-4dannjjm 5157 10 independent independent JJ cord-023095-4dannjjm 5157 11 predictor predictor NN cord-023095-4dannjjm 5157 12 of of IN cord-023095-4dannjjm 5157 13 prognosis prognosis NN cord-023095-4dannjjm 5157 14 in in IN cord-023095-4dannjjm 5157 15 human human JJ cord-023095-4dannjjm 5157 16 B B NNP cord-023095-4dannjjm 5157 17 cell cell NN cord-023095-4dannjjm 5157 18 lymphoma lymphoma NN cord-023095-4dannjjm 5157 19 . . . cord-023095-4dannjjm 5158 1 Low low JJ cord-023095-4dannjjm 5158 2 class class NN cord-023095-4dannjjm 5158 3 II II NNP cord-023095-4dannjjm 5158 4 MHC MHC NNP cord-023095-4dannjjm 5158 5 is be VBZ cord-023095-4dannjjm 5158 6 consistently consistently RB cord-023095-4dannjjm 5158 7 associated associate VBN cord-023095-4dannjjm 5158 8 with with IN cord-023095-4dannjjm 5158 9 poorer poor JJR cord-023095-4dannjjm 5158 10 outcome outcome NN cord-023095-4dannjjm 5158 11 . . . cord-023095-4dannjjm 5159 1 The the DT cord-023095-4dannjjm 5159 2 mechanism mechanism NN cord-023095-4dannjjm 5159 3 underlying underlie VBG cord-023095-4dannjjm 5159 4 this this DT cord-023095-4dannjjm 5159 5 relationship relationship NN cord-023095-4dannjjm 5159 6 is be VBZ cord-023095-4dannjjm 5159 7 not not RB cord-023095-4dannjjm 5159 8 clear clear JJ cord-023095-4dannjjm 5159 9 , , , cord-023095-4dannjjm 5159 10 but but CC cord-023095-4dannjjm 5159 11 one one CD cord-023095-4dannjjm 5159 12 hypothesis hypothesis NN cord-023095-4dannjjm 5159 13 is be VBZ cord-023095-4dannjjm 5159 14 that that IN cord-023095-4dannjjm 5159 15 high high JJ cord-023095-4dannjjm 5159 16 class class NN cord-023095-4dannjjm 5159 17 II II NNP cord-023095-4dannjjm 5159 18 MHC MHC NNP cord-023095-4dannjjm 5159 19 allows allow VBZ cord-023095-4dannjjm 5159 20 for for IN cord-023095-4dannjjm 5159 21 better well JJR cord-023095-4dannjjm 5159 22 antigen antigen NN cord-023095-4dannjjm 5159 23 presentation presentation NN cord-023095-4dannjjm 5159 24 and and CC cord-023095-4dannjjm 5159 25 tumor tumor NN cord-023095-4dannjjm 5159 26 - - HYPH cord-023095-4dannjjm 5159 27 specific specific JJ cord-023095-4dannjjm 5159 28 immune immune JJ cord-023095-4dannjjm 5159 29 responses response NNS cord-023095-4dannjjm 5159 30 . . . cord-023095-4dannjjm 5160 1 In in IN cord-023095-4dannjjm 5160 2 the the DT cord-023095-4dannjjm 5160 3 this this DT cord-023095-4dannjjm 5160 4 study study NN cord-023095-4dannjjm 5160 5 , , , cord-023095-4dannjjm 5160 6 we -PRON- PRP cord-023095-4dannjjm 5160 7 investigated investigate VBD cord-023095-4dannjjm 5160 8 whether whether IN cord-023095-4dannjjm 5160 9 that that DT cord-023095-4dannjjm 5160 10 class class NN cord-023095-4dannjjm 5160 11 II II NNP cord-023095-4dannjjm 5160 12 MHC MHC NNP cord-023095-4dannjjm 5160 13 expression expression NN cord-023095-4dannjjm 5160 14 in in IN cord-023095-4dannjjm 5160 15 canine canine JJ cord-023095-4dannjjm 5160 16 B B NNP cord-023095-4dannjjm 5160 17 cell cell NN cord-023095-4dannjjm 5160 18 lymphoma lymphoma NN cord-023095-4dannjjm 5160 19 was be VBD cord-023095-4dannjjm 5160 20 associated associate VBN cord-023095-4dannjjm 5160 21 with with IN cord-023095-4dannjjm 5160 22 remission remission NN cord-023095-4dannjjm 5160 23 and and CC cord-023095-4dannjjm 5160 24 survival survival NN cord-023095-4dannjjm 5160 25 times time NNS cord-023095-4dannjjm 5160 26 . . . cord-023095-4dannjjm 5161 1 A a DT cord-023095-4dannjjm 5161 2 total total NN cord-023095-4dannjjm 5161 3 of of IN cord-023095-4dannjjm 5161 4 160 160 CD cord-023095-4dannjjm 5161 5 patients patient NNS cord-023095-4dannjjm 5161 6 were be VBD cord-023095-4dannjjm 5161 7 categorized categorize VBN cord-023095-4dannjjm 5161 8 by by IN cord-023095-4dannjjm 5161 9 level level NN cord-023095-4dannjjm 5161 10 of of IN cord-023095-4dannjjm 5161 11 class class NN cord-023095-4dannjjm 5161 12 II II NNP cord-023095-4dannjjm 5161 13 MHC MHC NNP cord-023095-4dannjjm 5161 14 , , , cord-023095-4dannjjm 5161 15 expression expression NN cord-023095-4dannjjm 5161 16 of of IN cord-023095-4dannjjm 5161 17 CD34 CD34 NNP cord-023095-4dannjjm 5161 18 and and CC cord-023095-4dannjjm 5161 19 cell cell NN cord-023095-4dannjjm 5161 20 size size NN cord-023095-4dannjjm 5161 21 for for IN cord-023095-4dannjjm 5161 22 on on IN cord-023095-4dannjjm 5161 23 neoplastic neoplastic JJ cord-023095-4dannjjm 5161 24 B b NN cord-023095-4dannjjm 5161 25 cells cell NNS cord-023095-4dannjjm 5161 26 . . . cord-023095-4dannjjm 5162 1 Multivariable Multivariable NNP cord-023095-4dannjjm 5162 2 Cox Cox NNP cord-023095-4dannjjm 5162 3 - - HYPH cord-023095-4dannjjm 5162 4 proportional proportional JJ cord-023095-4dannjjm 5162 5 hazard hazard NN cord-023095-4dannjjm 5162 6 analysis analysis NN cord-023095-4dannjjm 5162 7 was be VBD cord-023095-4dannjjm 5162 8 used use VBN cord-023095-4dannjjm 5162 9 investigate investigate VB cord-023095-4dannjjm 5162 10 this this DT cord-023095-4dannjjm 5162 11 research research NN cord-023095-4dannjjm 5162 12 question question NN cord-023095-4dannjjm 5162 13 using use VBG cord-023095-4dannjjm 5162 14 a a DT cord-023095-4dannjjm 5162 15 randomly randomly RB cord-023095-4dannjjm 5162 16 selected select VBN cord-023095-4dannjjm 5162 17 subset subset JJ cord-023095-4dannjjm 5162 18 of of IN cord-023095-4dannjjm 5162 19 the the DT cord-023095-4dannjjm 5162 20 data datum NNS cord-023095-4dannjjm 5162 21 , , , cord-023095-4dannjjm 5162 22 and and CC cord-023095-4dannjjm 5162 23 the the DT cord-023095-4dannjjm 5162 24 predictive predictive JJ cord-023095-4dannjjm 5162 25 ability ability NN cord-023095-4dannjjm 5162 26 of of IN cord-023095-4dannjjm 5162 27 this this DT cord-023095-4dannjjm 5162 28 model model NN cord-023095-4dannjjm 5162 29 was be VBD cord-023095-4dannjjm 5162 30 validated validate VBN cord-023095-4dannjjm 5162 31 on on IN cord-023095-4dannjjm 5162 32 the the DT cord-023095-4dannjjm 5162 33 remaining remain VBG cord-023095-4dannjjm 5162 34 1/3 1/3 CD cord-023095-4dannjjm 5162 35 of of IN cord-023095-4dannjjm 5162 36 patient patient JJ cord-023095-4dannjjm 5162 37 data datum NNS cord-023095-4dannjjm 5162 38 . . . cord-023095-4dannjjm 5163 1 Results result NNS cord-023095-4dannjjm 5163 2 suggested suggest VBD cord-023095-4dannjjm 5163 3 that that IN cord-023095-4dannjjm 5163 4 low low JJ cord-023095-4dannjjm 5163 5 class class NN cord-023095-4dannjjm 5163 6 II II NNP cord-023095-4dannjjm 5163 7 MHC MHC NNP cord-023095-4dannjjm 5163 8 expression expression NN cord-023095-4dannjjm 5163 9 was be VBD cord-023095-4dannjjm 5163 10 associated associate VBN cord-023095-4dannjjm 5163 11 with with IN cord-023095-4dannjjm 5163 12 decreased decreased JJ cord-023095-4dannjjm 5163 13 times time NNS cord-023095-4dannjjm 5163 14 to to TO cord-023095-4dannjjm 5163 15 relapse relapse VB cord-023095-4dannjjm 5163 16 and and CC cord-023095-4dannjjm 5163 17 death death NN cord-023095-4dannjjm 5163 18 as as IN cord-023095-4dannjjm 5163 19 is be VBZ cord-023095-4dannjjm 5163 20 seen see VBN cord-023095-4dannjjm 5163 21 in in IN cord-023095-4dannjjm 5163 22 human human JJ cord-023095-4dannjjm 5163 23 B b NN cord-023095-4dannjjm 5163 24 cell cell NN cord-023095-4dannjjm 5163 25 lymphoma lymphoma NN cord-023095-4dannjjm 5163 26 , , , cord-023095-4dannjjm 5163 27 and and CC cord-023095-4dannjjm 5163 28 that that IN cord-023095-4dannjjm 5163 29 large large JJ cord-023095-4dannjjm 5163 30 neoplastic neoplastic JJ cord-023095-4dannjjm 5163 31 cells cell NNS cord-023095-4dannjjm 5163 32 were be VBD cord-023095-4dannjjm 5163 33 associated associate VBN cord-023095-4dannjjm 5163 34 with with IN cord-023095-4dannjjm 5163 35 decreased decreased JJ cord-023095-4dannjjm 5163 36 survival survival NN cord-023095-4dannjjm 5163 37 time time NN cord-023095-4dannjjm 5163 38 . . . cord-023095-4dannjjm 5164 1 CD34 CD34 NNP cord-023095-4dannjjm 5164 2 expression expression NN cord-023095-4dannjjm 5164 3 was be VBD cord-023095-4dannjjm 5164 4 not not RB cord-023095-4dannjjm 5164 5 associated associate VBN cord-023095-4dannjjm 5164 6 with with IN cord-023095-4dannjjm 5164 7 patient patient JJ cord-023095-4dannjjm 5164 8 outcomes outcome NNS cord-023095-4dannjjm 5164 9 . . . cord-023095-4dannjjm 5165 1 These these DT cord-023095-4dannjjm 5165 2 findings finding NNS cord-023095-4dannjjm 5165 3 have have VBP cord-023095-4dannjjm 5165 4 implications implication NNS cord-023095-4dannjjm 5165 5 for for IN cord-023095-4dannjjm 5165 6 the the DT cord-023095-4dannjjm 5165 7 use use NN cord-023095-4dannjjm 5165 8 of of IN cord-023095-4dannjjm 5165 9 dogs dog NNS cord-023095-4dannjjm 5165 10 to to TO cord-023095-4dannjjm 5165 11 model model VB cord-023095-4dannjjm 5165 12 human human JJ cord-023095-4dannjjm 5165 13 lymphomas lymphoma NNS cord-023095-4dannjjm 5165 14 , , , cord-023095-4dannjjm 5165 15 for for IN cord-023095-4dannjjm 5165 16 the the DT cord-023095-4dannjjm 5165 17 study study NN cord-023095-4dannjjm 5165 18 of of IN cord-023095-4dannjjm 5165 19 tumor tumor NN cord-023095-4dannjjm 5165 20 vaccines vaccine NNS cord-023095-4dannjjm 5165 21 , , , cord-023095-4dannjjm 5165 22 and and CC cord-023095-4dannjjm 5165 23 for for IN cord-023095-4dannjjm 5165 24 prediction prediction NN cord-023095-4dannjjm 5165 25 of of IN cord-023095-4dannjjm 5165 26 mortality mortality NN cord-023095-4dannjjm 5165 27 in in IN cord-023095-4dannjjm 5165 28 dogs dog NNS cord-023095-4dannjjm 5165 29 with with IN cord-023095-4dannjjm 5165 30 B b NN cord-023095-4dannjjm 5165 31 cell cell NN cord-023095-4dannjjm 5165 32 lymphoma lymphoma NN cord-023095-4dannjjm 5165 33 with with IN cord-023095-4dannjjm 5165 34 a a DT cord-023095-4dannjjm 5165 35 high high JJ cord-023095-4dannjjm 5165 36 level level NN cord-023095-4dannjjm 5165 37 of of IN cord-023095-4dannjjm 5165 38 specificity specificity NN cord-023095-4dannjjm 5165 39 . . . cord-023095-4dannjjm 5166 1 One one CD cord-023095-4dannjjm 5166 2 of of IN cord-023095-4dannjjm 5166 3 the the DT cord-023095-4dannjjm 5166 4 reasons reason NNS cord-023095-4dannjjm 5166 5 for for IN cord-023095-4dannjjm 5166 6 the the DT cord-023095-4dannjjm 5166 7 failure failure NN cord-023095-4dannjjm 5166 8 of of IN cord-023095-4dannjjm 5166 9 canine canine JJ cord-023095-4dannjjm 5166 10 lymphoma lymphoma NN cord-023095-4dannjjm 5166 11 treatment treatment NN cord-023095-4dannjjm 5166 12 is be VBZ cord-023095-4dannjjm 5166 13 related relate VBN cord-023095-4dannjjm 5166 14 to to IN cord-023095-4dannjjm 5166 15 the the DT cord-023095-4dannjjm 5166 16 resistance resistance NN cord-023095-4dannjjm 5166 17 of of IN cord-023095-4dannjjm 5166 18 tumor tumor NN cord-023095-4dannjjm 5166 19 cells cell NNS cord-023095-4dannjjm 5166 20 against against IN cord-023095-4dannjjm 5166 21 chemotherapy chemotherapy NN cord-023095-4dannjjm 5166 22 drugs drug NNS cord-023095-4dannjjm 5166 23 . . . cord-023095-4dannjjm 5167 1 The the DT cord-023095-4dannjjm 5167 2 major major JJ cord-023095-4dannjjm 5167 3 form form NN cord-023095-4dannjjm 5167 4 of of IN cord-023095-4dannjjm 5167 5 this this DT cord-023095-4dannjjm 5167 6 resistance resistance NN cord-023095-4dannjjm 5167 7 is be VBZ cord-023095-4dannjjm 5167 8 provide provide JJ cord-023095-4dannjjm 5167 9 by by IN cord-023095-4dannjjm 5167 10 multidrug multidrug NN cord-023095-4dannjjm 5167 11 resistance resistance NN cord-023095-4dannjjm 5167 12 ABC ABC NNP cord-023095-4dannjjm 5167 13 transporters transporter NNS cord-023095-4dannjjm 5167 14 . . . cord-023095-4dannjjm 5168 1 ABC ABC NNP cord-023095-4dannjjm 5168 2 transporters transporter NNS cord-023095-4dannjjm 5168 3 proteins protein NNS cord-023095-4dannjjm 5168 4 comprise comprise VBP cord-023095-4dannjjm 5168 5 a a DT cord-023095-4dannjjm 5168 6 large large JJ cord-023095-4dannjjm 5168 7 superfamily superfamily NN cord-023095-4dannjjm 5168 8 of of IN cord-023095-4dannjjm 5168 9 transmembrane transmembrane JJ cord-023095-4dannjjm 5168 10 proteins protein NNS cord-023095-4dannjjm 5168 11 , , , cord-023095-4dannjjm 5168 12 ATP ATP NNP cord-023095-4dannjjm 5168 13 - - HYPH cord-023095-4dannjjm 5168 14 dependent dependent JJ cord-023095-4dannjjm 5168 15 , , , cord-023095-4dannjjm 5168 16 that that WDT cord-023095-4dannjjm 5168 17 extrude extrude VBP cord-023095-4dannjjm 5168 18 a a DT cord-023095-4dannjjm 5168 19 large large JJ cord-023095-4dannjjm 5168 20 variety variety NN cord-023095-4dannjjm 5168 21 of of IN cord-023095-4dannjjm 5168 22 drugs drug NNS cord-023095-4dannjjm 5168 23 from from IN cord-023095-4dannjjm 5168 24 the the DT cord-023095-4dannjjm 5168 25 cells cell NNS cord-023095-4dannjjm 5168 26 . . . cord-023095-4dannjjm 5169 1 Multidrug multidrug JJ cord-023095-4dannjjm 5169 2 resistance resistance NN cord-023095-4dannjjm 5169 3 phenotype phenotype NN cord-023095-4dannjjm 5169 4 in in IN cord-023095-4dannjjm 5169 5 cancer cancer NN cord-023095-4dannjjm 5169 6 cells cell NNS cord-023095-4dannjjm 5169 7 is be VBZ cord-023095-4dannjjm 5169 8 associated associate VBN cord-023095-4dannjjm 5169 9 with with IN cord-023095-4dannjjm 5169 10 overexpression overexpression NN cord-023095-4dannjjm 5169 11 of of IN cord-023095-4dannjjm 5169 12 these these DT cord-023095-4dannjjm 5169 13 transmembrane transmembrane NN cord-023095-4dannjjm 5169 14 proteins protein NNS cord-023095-4dannjjm 5169 15 . . . cord-023095-4dannjjm 5170 1 ABCG2 ABCG2 NNS cord-023095-4dannjjm 5170 2 , , , cord-023095-4dannjjm 5170 3 also also RB cord-023095-4dannjjm 5170 4 known know VBN cord-023095-4dannjjm 5170 5 as as IN cord-023095-4dannjjm 5170 6 BCRP BCRP NNP cord-023095-4dannjjm 5170 7 , , , cord-023095-4dannjjm 5170 8 is be VBZ cord-023095-4dannjjm 5170 9 a a DT cord-023095-4dannjjm 5170 10 655 655 CD cord-023095-4dannjjm 5170 11 residue residue JJ cord-023095-4dannjjm 5170 12 half half JJ cord-023095-4dannjjm 5170 13 - - HYPH cord-023095-4dannjjm 5170 14 transporter transporter NN cord-023095-4dannjjm 5170 15 protein protein NN cord-023095-4dannjjm 5170 16 that that WDT cord-023095-4dannjjm 5170 17 protect protect VBP cord-023095-4dannjjm 5170 18 hematopoetic hematopoetic JJ cord-023095-4dannjjm 5170 19 stem stem NN cord-023095-4dannjjm 5170 20 cells cell NNS cord-023095-4dannjjm 5170 21 against against IN cord-023095-4dannjjm 5170 22 toxic toxic JJ cord-023095-4dannjjm 5170 23 compounds compound NNS cord-023095-4dannjjm 5170 24 . . . cord-023095-4dannjjm 5171 1 The the DT cord-023095-4dannjjm 5171 2 aim aim NN cord-023095-4dannjjm 5171 3 of of IN cord-023095-4dannjjm 5171 4 this this DT cord-023095-4dannjjm 5171 5 study study NN cord-023095-4dannjjm 5171 6 was be VBD cord-023095-4dannjjm 5171 7 to to TO cord-023095-4dannjjm 5171 8 investigate investigate VB cord-023095-4dannjjm 5171 9 the the DT cord-023095-4dannjjm 5171 10 expression expression NN cord-023095-4dannjjm 5171 11 of of IN cord-023095-4dannjjm 5171 12 BCRP BCRP NNP cord-023095-4dannjjm 5171 13 ( ( -LRB- cord-023095-4dannjjm 5171 14 ABCG2 abcg2 NN cord-023095-4dannjjm 5171 15 ) ) -RRB- cord-023095-4dannjjm 5171 16 in in IN cord-023095-4dannjjm 5171 17 canine canine JJ cord-023095-4dannjjm 5171 18 multicentric multicentric JJ cord-023095-4dannjjm 5171 19 lymphoma lymphoma NN cord-023095-4dannjjm 5171 20 . . . cord-023095-4dannjjm 5172 1 Samples sample NNS cord-023095-4dannjjm 5172 2 were be VBD cord-023095-4dannjjm 5172 3 collected collect VBN cord-023095-4dannjjm 5172 4 by by IN cord-023095-4dannjjm 5172 5 fine fine JJ cord-023095-4dannjjm 5172 6 needle needle NN cord-023095-4dannjjm 5172 7 aspiration aspiration NN cord-023095-4dannjjm 5172 8 of of IN cord-023095-4dannjjm 5172 9 an an DT cord-023095-4dannjjm 5172 10 enlarged enlarged JJ cord-023095-4dannjjm 5172 11 lymph lymph NN cord-023095-4dannjjm 5172 12 nodes node NNS cord-023095-4dannjjm 5172 13 , , , cord-023095-4dannjjm 5172 14 from from IN cord-023095-4dannjjm 5172 15 25 25 CD cord-023095-4dannjjm 5172 16 dogs dog NNS cord-023095-4dannjjm 5172 17 with with IN cord-023095-4dannjjm 5172 18 multicentric multicentric JJ cord-023095-4dannjjm 5172 19 lymphoma lymphoma NN cord-023095-4dannjjm 5172 20 ( ( -LRB- cord-023095-4dannjjm 5172 21 stage stage NN cord-023095-4dannjjm 5172 22 III III NNP cord-023095-4dannjjm 5172 23 to to IN cord-023095-4dannjjm 5172 24 V v NN cord-023095-4dannjjm 5172 25 ) ) -RRB- cord-023095-4dannjjm 5172 26 at at IN cord-023095-4dannjjm 5172 27 diagnosis diagnosis NN cord-023095-4dannjjm 5172 28 , , , cord-023095-4dannjjm 5172 29 and and CC cord-023095-4dannjjm 5172 30 8 8 CD cord-023095-4dannjjm 5172 31 normal normal JJ cord-023095-4dannjjm 5172 32 lymph lymph NN cord-023095-4dannjjm 5172 33 nodes node NNS cord-023095-4dannjjm 5172 34 ( ( -LRB- cord-023095-4dannjjm 5172 35 control control NN cord-023095-4dannjjm 5172 36 ) ) -RRB- cord-023095-4dannjjm 5172 37 . . . cord-023095-4dannjjm 5173 1 Dogs dog NNS cord-023095-4dannjjm 5173 2 that that WDT cord-023095-4dannjjm 5173 3 were be VBD cord-023095-4dannjjm 5173 4 previously previously RB cord-023095-4dannjjm 5173 5 treated treat VBN cord-023095-4dannjjm 5173 6 with with IN cord-023095-4dannjjm 5173 7 prednisone prednisone NN cord-023095-4dannjjm 5173 8 or or CC cord-023095-4dannjjm 5173 9 chemotherapy chemotherapy NN cord-023095-4dannjjm 5173 10 were be VBD cord-023095-4dannjjm 5173 11 excluded exclude VBN cord-023095-4dannjjm 5173 12 from from IN cord-023095-4dannjjm 5173 13 the the DT cord-023095-4dannjjm 5173 14 study study NN cord-023095-4dannjjm 5173 15 . . . cord-023095-4dannjjm 5174 1 Quantitative quantitative JJ cord-023095-4dannjjm 5174 2 RT RT NNP cord-023095-4dannjjm 5174 3 - - HYPH cord-023095-4dannjjm 5174 4 PCR PCR NNP cord-023095-4dannjjm 5174 5 was be VBD cord-023095-4dannjjm 5174 6 used use VBN cord-023095-4dannjjm 5174 7 to to TO cord-023095-4dannjjm 5174 8 measure measure VB cord-023095-4dannjjm 5174 9 the the DT cord-023095-4dannjjm 5174 10 mRNA mRNA NNP cord-023095-4dannjjm 5174 11 expression expression NN cord-023095-4dannjjm 5174 12 level level NN cord-023095-4dannjjm 5174 13 of of IN cord-023095-4dannjjm 5174 14 BCRP BCRP NNP cord-023095-4dannjjm 5174 15 and and CC cord-023095-4dannjjm 5174 16 FLNB FLNB NNP cord-023095-4dannjjm 5174 17 expression expression NN cord-023095-4dannjjm 5174 18 as as IN cord-023095-4dannjjm 5174 19 a a DT cord-023095-4dannjjm 5174 20 endogenous endogenous JJ cord-023095-4dannjjm 5174 21 reference reference NN cord-023095-4dannjjm 5174 22 canine canine JJ cord-023095-4dannjjm 5174 23 gene gene NN cord-023095-4dannjjm 5174 24 . . . cord-023095-4dannjjm 5175 1 A a DT cord-023095-4dannjjm 5175 2 widely widely RB cord-023095-4dannjjm 5175 3 range range JJ cord-023095-4dannjjm 5175 4 expression expression NN cord-023095-4dannjjm 5175 5 value value NN cord-023095-4dannjjm 5175 6 for for IN cord-023095-4dannjjm 5175 7 ABCG2 abcg2 NN cord-023095-4dannjjm 5175 8 expression expression NN cord-023095-4dannjjm 5175 9 was be VBD cord-023095-4dannjjm 5175 10 found find VBN cord-023095-4dannjjm 5175 11 for for IN cord-023095-4dannjjm 5175 12 canine canine JJ cord-023095-4dannjjm 5175 13 multicentric multicentric JJ cord-023095-4dannjjm 5175 14 lymphoma lymphoma NN cord-023095-4dannjjm 5175 15 . . . cord-023095-4dannjjm 5176 1 High high JJ cord-023095-4dannjjm 5176 2 gene gene NN cord-023095-4dannjjm 5176 3 expression expression NN cord-023095-4dannjjm 5176 4 was be VBD cord-023095-4dannjjm 5176 5 observed observe VBN cord-023095-4dannjjm 5176 6 in in IN cord-023095-4dannjjm 5176 7 52 52 CD cord-023095-4dannjjm 5176 8 % % NN cord-023095-4dannjjm 5176 9 ( ( -LRB- cord-023095-4dannjjm 5176 10 13/25 13/25 CD cord-023095-4dannjjm 5176 11 ) ) -RRB- cord-023095-4dannjjm 5176 12 canine canine JJ cord-023095-4dannjjm 5176 13 lymphoma lymphoma NN cord-023095-4dannjjm 5176 14 , , , cord-023095-4dannjjm 5176 15 but but CC cord-023095-4dannjjm 5176 16 48 48 CD cord-023095-4dannjjm 5176 17 % % NN cord-023095-4dannjjm 5176 18 of of IN cord-023095-4dannjjm 5176 19 dogs dog NNS cord-023095-4dannjjm 5176 20 had have VBD cord-023095-4dannjjm 5176 21 a a DT cord-023095-4dannjjm 5176 22 lower low JJR cord-023095-4dannjjm 5176 23 expression expression NN cord-023095-4dannjjm 5176 24 when when WRB cord-023095-4dannjjm 5176 25 compared compare VBN cord-023095-4dannjjm 5176 26 with with IN cord-023095-4dannjjm 5176 27 normal normal JJ cord-023095-4dannjjm 5176 28 lymph lymph NN cord-023095-4dannjjm 5176 29 node node NN cord-023095-4dannjjm 5176 30 . . . cord-023095-4dannjjm 5177 1 Gene gene NN cord-023095-4dannjjm 5177 2 expression expression NN cord-023095-4dannjjm 5177 3 was be VBD cord-023095-4dannjjm 5177 4 not not RB cord-023095-4dannjjm 5177 5 associated associate VBN cord-023095-4dannjjm 5177 6 with with IN cord-023095-4dannjjm 5177 7 clinical clinical JJ cord-023095-4dannjjm 5177 8 staging staging NN cord-023095-4dannjjm 5177 9 , , , cord-023095-4dannjjm 5177 10 complete complete JJ cord-023095-4dannjjm 5177 11 or or CC cord-023095-4dannjjm 5177 12 partial partial JJ cord-023095-4dannjjm 5177 13 remission remission NN cord-023095-4dannjjm 5177 14 , , , cord-023095-4dannjjm 5177 15 relapse relapse NN cord-023095-4dannjjm 5177 16 and and CC cord-023095-4dannjjm 5177 17 survival survival NN cord-023095-4dannjjm 5177 18 time time NN cord-023095-4dannjjm 5177 19 . . . cord-023095-4dannjjm 5178 1 In in IN cord-023095-4dannjjm 5178 2 conclusion conclusion NN cord-023095-4dannjjm 5178 3 , , , cord-023095-4dannjjm 5178 4 ABCG2 ABCG2 NNP cord-023095-4dannjjm 5178 5 was be VBD cord-023095-4dannjjm 5178 6 expressed express VBN cord-023095-4dannjjm 5178 7 in in IN cord-023095-4dannjjm 5178 8 canine canine JJ cord-023095-4dannjjm 5178 9 lymph lymph NN cord-023095-4dannjjm 5178 10 node node NN cord-023095-4dannjjm 5178 11 and and CC cord-023095-4dannjjm 5178 12 canine canine JJ cord-023095-4dannjjm 5178 13 multicentric multicentric JJ cord-023095-4dannjjm 5178 14 lymphoma lymphoma NN cord-023095-4dannjjm 5178 15 at at IN cord-023095-4dannjjm 5178 16 the the DT cord-023095-4dannjjm 5178 17 diagnosis diagnosis NN cord-023095-4dannjjm 5178 18 , , , cord-023095-4dannjjm 5178 19 and and CC cord-023095-4dannjjm 5178 20 it -PRON- PRP cord-023095-4dannjjm 5178 21 was be VBD cord-023095-4dannjjm 5178 22 not not RB cord-023095-4dannjjm 5178 23 correlated correlate VBN cord-023095-4dannjjm 5178 24 with with IN cord-023095-4dannjjm 5178 25 clinical clinical JJ cord-023095-4dannjjm 5178 26 response response NN cord-023095-4dannjjm 5178 27 . . . cord-023095-4dannjjm 5179 1 Osteosarcoma Osteosarcoma NNP cord-023095-4dannjjm 5179 2 ( ( -LRB- cord-023095-4dannjjm 5179 3 OSA OSA NNP cord-023095-4dannjjm 5179 4 ) ) -RRB- cord-023095-4dannjjm 5179 5 , , , cord-023095-4dannjjm 5179 6 the the DT cord-023095-4dannjjm 5179 7 most most RBS cord-023095-4dannjjm 5179 8 frequent frequent JJ cord-023095-4dannjjm 5179 9 primary primary JJ cord-023095-4dannjjm 5179 10 malignant malignant JJ cord-023095-4dannjjm 5179 11 bone bone NN cord-023095-4dannjjm 5179 12 tumor tumor NN cord-023095-4dannjjm 5179 13 of of IN cord-023095-4dannjjm 5179 14 dogs dog NNS cord-023095-4dannjjm 5179 15 , , , cord-023095-4dannjjm 5179 16 is be VBZ cord-023095-4dannjjm 5179 17 both both DT cord-023095-4dannjjm 5179 18 locally locally RB cord-023095-4dannjjm 5179 19 aggressive aggressive JJ cord-023095-4dannjjm 5179 20 and and CC cord-023095-4dannjjm 5179 21 highly highly RB cord-023095-4dannjjm 5179 22 metastatic metastatic JJ cord-023095-4dannjjm 5179 23 . . . cord-023095-4dannjjm 5180 1 Prognostic prognostic JJ cord-023095-4dannjjm 5180 2 factors factor NNS cord-023095-4dannjjm 5180 3 for for IN cord-023095-4dannjjm 5180 4 canine canine JJ cord-023095-4dannjjm 5180 5 OSA OSA NNP cord-023095-4dannjjm 5180 6 include include VBP cord-023095-4dannjjm 5180 7 tumor tumor NN cord-023095-4dannjjm 5180 8 location location NN cord-023095-4dannjjm 5180 9 , , , cord-023095-4dannjjm 5180 10 distant distant JJ cord-023095-4dannjjm 5180 11 metastatic metastatic JJ cord-023095-4dannjjm 5180 12 disease disease NN cord-023095-4dannjjm 5180 13 , , , cord-023095-4dannjjm 5180 14 and and CC cord-023095-4dannjjm 5180 15 serum serum NN cord-023095-4dannjjm 5180 16 alkaline alkaline JJ cord-023095-4dannjjm 5180 17 phosphatase phosphatase NN cord-023095-4dannjjm 5180 18 ( ( -LRB- cord-023095-4dannjjm 5180 19 ALP ALP NNP cord-023095-4dannjjm 5180 20 ) ) -RRB- cord-023095-4dannjjm 5180 21 concentration concentration NN cord-023095-4dannjjm 5180 22 . . . cord-023095-4dannjjm 5181 1 An an DT cord-023095-4dannjjm 5181 2 increased increase VBN cord-023095-4dannjjm 5181 3 serum serum NN cord-023095-4dannjjm 5181 4 ALP ALP NNP cord-023095-4dannjjm 5181 5 concentration concentration NN cord-023095-4dannjjm 5181 6 is be VBZ cord-023095-4dannjjm 5181 7 associated associate VBN cord-023095-4dannjjm 5181 8 with with IN cord-023095-4dannjjm 5181 9 poor poor JJ cord-023095-4dannjjm 5181 10 prognosis prognosis NN cord-023095-4dannjjm 5181 11 ; ; : cord-023095-4dannjjm 5181 12 however however RB cord-023095-4dannjjm 5181 13 the the DT cord-023095-4dannjjm 5181 14 mechanisms mechanism NNS cord-023095-4dannjjm 5181 15 underlying underlie VBG cord-023095-4dannjjm 5181 16 this this DT cord-023095-4dannjjm 5181 17 phenomenon phenomenon NN cord-023095-4dannjjm 5181 18 are be VBP cord-023095-4dannjjm 5181 19 currently currently RB cord-023095-4dannjjm 5181 20 unclear unclear JJ cord-023095-4dannjjm 5181 21 . . . cord-023095-4dannjjm 5182 1 During during IN cord-023095-4dannjjm 5182 2 normal normal JJ cord-023095-4dannjjm 5182 3 bone bone NN cord-023095-4dannjjm 5182 4 development development NN cord-023095-4dannjjm 5182 5 ALP ALP NNP cord-023095-4dannjjm 5182 6 may may MD cord-023095-4dannjjm 5182 7 be be VB cord-023095-4dannjjm 5182 8 used use VBN cord-023095-4dannjjm 5182 9 as as IN cord-023095-4dannjjm 5182 10 a a DT cord-023095-4dannjjm 5182 11 marker marker NN cord-023095-4dannjjm 5182 12 for for IN cord-023095-4dannjjm 5182 13 osteoblasts osteoblast NNS cord-023095-4dannjjm 5182 14 . . . cord-023095-4dannjjm 5183 1 Additionally additionally RB cord-023095-4dannjjm 5183 2 , , , cord-023095-4dannjjm 5183 3 ALP ALP NNP cord-023095-4dannjjm 5183 4 is be VBZ cord-023095-4dannjjm 5183 5 a a DT cord-023095-4dannjjm 5183 6 downstream downstream JJ cord-023095-4dannjjm 5183 7 target target NN cord-023095-4dannjjm 5183 8 of of IN cord-023095-4dannjjm 5183 9 activated activate VBN cord-023095-4dannjjm 5183 10 canonical canonical JJ cord-023095-4dannjjm 5183 11 Wnt Wnt NNP cord-023095-4dannjjm 5183 12 / / SYM cord-023095-4dannjjm 5183 13 b b NN cord-023095-4dannjjm 5183 14 - - HYPH cord-023095-4dannjjm 5183 15 catenin catenin NN cord-023095-4dannjjm 5183 16 signaling signaling NN cord-023095-4dannjjm 5183 17 . . . cord-023095-4dannjjm 5184 1 Therefore therefore RB cord-023095-4dannjjm 5184 2 , , , cord-023095-4dannjjm 5184 3 we -PRON- PRP cord-023095-4dannjjm 5184 4 hypothesized hypothesize VBD cord-023095-4dannjjm 5184 5 that that IN cord-023095-4dannjjm 5184 6 increased increase VBN cord-023095-4dannjjm 5184 7 serum serum NN cord-023095-4dannjjm 5184 8 ALP ALP NNP cord-023095-4dannjjm 5184 9 would would MD cord-023095-4dannjjm 5184 10 be be VB cord-023095-4dannjjm 5184 11 associated associate VBN cord-023095-4dannjjm 5184 12 with with IN cord-023095-4dannjjm 5184 13 increased increase VBN cord-023095-4dannjjm 5184 14 expression expression NN cord-023095-4dannjjm 5184 15 of of IN cord-023095-4dannjjm 5184 16 b b NN cord-023095-4dannjjm 5184 17 - - HYPH cord-023095-4dannjjm 5184 18 catenin catenin NNS cord-023095-4dannjjm 5184 19 in in IN cord-023095-4dannjjm 5184 20 canine canine JJ cord-023095-4dannjjm 5184 21 OSA OSA NNP cord-023095-4dannjjm 5184 22 . . . cord-023095-4dannjjm 5185 1 The the DT cord-023095-4dannjjm 5185 2 goals goal NNS cord-023095-4dannjjm 5185 3 of of IN cord-023095-4dannjjm 5185 4 this this DT cord-023095-4dannjjm 5185 5 study study NN cord-023095-4dannjjm 5185 6 were be VBD cord-023095-4dannjjm 5185 7 : : : cord-023095-4dannjjm 5185 8 ( ( -LRB- cord-023095-4dannjjm 5185 9 1 1 LS cord-023095-4dannjjm 5185 10 ) ) -RRB- cord-023095-4dannjjm 5185 11 characterize characterize VB cord-023095-4dannjjm 5185 12 and and CC cord-023095-4dannjjm 5185 13 compare compare VB cord-023095-4dannjjm 5185 14 cellular cellular JJ cord-023095-4dannjjm 5185 15 ALP ALP NNP cord-023095-4dannjjm 5185 16 expression expression NN cord-023095-4dannjjm 5185 17 in in IN cord-023095-4dannjjm 5185 18 OSA OSA NNP cord-023095-4dannjjm 5185 19 tissue tissue NN cord-023095-4dannjjm 5185 20 from from IN cord-023095-4dannjjm 5185 21 patients patient NNS cord-023095-4dannjjm 5185 22 with with IN cord-023095-4dannjjm 5185 23 normal normal JJ cord-023095-4dannjjm 5185 24 and and CC cord-023095-4dannjjm 5185 25 high high JJ cord-023095-4dannjjm 5185 26 serum serum NN cord-023095-4dannjjm 5185 27 ALP alp NN cord-023095-4dannjjm 5185 28 ; ; : cord-023095-4dannjjm 5185 29 and and CC cord-023095-4dannjjm 5185 30 ( ( -LRB- cord-023095-4dannjjm 5185 31 2 2 LS cord-023095-4dannjjm 5185 32 ) ) -RRB- cord-023095-4dannjjm 5185 33 assess assess VB cord-023095-4dannjjm 5185 34 b b NN cord-023095-4dannjjm 5185 35 - - HYPH cord-023095-4dannjjm 5185 36 catenin catenin NN cord-023095-4dannjjm 5185 37 expression expression NN cord-023095-4dannjjm 5185 38 in in IN cord-023095-4dannjjm 5185 39 those those DT cord-023095-4dannjjm 5185 40 same same JJ cord-023095-4dannjjm 5185 41 patient patient JJ cord-023095-4dannjjm 5185 42 populations population NNS cord-023095-4dannjjm 5185 43 . . . cord-023095-4dannjjm 5186 1 We -PRON- PRP cord-023095-4dannjjm 5186 2 used use VBD cord-023095-4dannjjm 5186 3 frozen freeze VBN cord-023095-4dannjjm 5186 4 OSA OSA NNP cord-023095-4dannjjm 5186 5 samples sample NNS cord-023095-4dannjjm 5186 6 collected collect VBN cord-023095-4dannjjm 5186 7 from from IN cord-023095-4dannjjm 5186 8 patients patient NNS cord-023095-4dannjjm 5186 9 with with IN cord-023095-4dannjjm 5186 10 either either CC cord-023095-4dannjjm 5186 11 high high JJ cord-023095-4dannjjm 5186 12 ALP ALP NNP cord-023095-4dannjjm 5186 13 ( ( -LRB- cord-023095-4dannjjm 5186 14 n n NN cord-023095-4dannjjm 5186 15 5 5 CD cord-023095-4dannjjm 5186 16 3 3 CD cord-023095-4dannjjm 5186 17 ) ) -RRB- cord-023095-4dannjjm 5186 18 or or CC cord-023095-4dannjjm 5186 19 normal normal JJ cord-023095-4dannjjm 5186 20 ALP ALP NNP cord-023095-4dannjjm 5186 21 ( ( -LRB- cord-023095-4dannjjm 5186 22 n n NN cord-023095-4dannjjm 5186 23 5 5 CD cord-023095-4dannjjm 5186 24 3 3 CD cord-023095-4dannjjm 5186 25 ) ) -RRB- cord-023095-4dannjjm 5186 26 . . . cord-023095-4dannjjm 5187 1 Total Total NNP cord-023095-4dannjjm 5187 2 RNA RNA NNP cord-023095-4dannjjm 5187 3 was be VBD cord-023095-4dannjjm 5187 4 isolated isolate VBN cord-023095-4dannjjm 5187 5 from from IN cord-023095-4dannjjm 5187 6 the the DT cord-023095-4dannjjm 5187 7 frozen frozen JJ cord-023095-4dannjjm 5187 8 tissue tissue NN cord-023095-4dannjjm 5187 9 , , , cord-023095-4dannjjm 5187 10 converted convert VBN cord-023095-4dannjjm 5187 11 to to IN cord-023095-4dannjjm 5187 12 cDNA cdna NN cord-023095-4dannjjm 5187 13 , , , cord-023095-4dannjjm 5187 14 and and CC cord-023095-4dannjjm 5187 15 analyzed analyze VBD cord-023095-4dannjjm 5187 16 using use VBG cord-023095-4dannjjm 5187 17 quantitative quantitative JJ cord-023095-4dannjjm 5187 18 reverse reverse NN cord-023095-4dannjjm 5187 19 - - HYPH cord-023095-4dannjjm 5187 20 transcriptase transcriptase NN cord-023095-4dannjjm 5187 21 polymerase polymerase NN cord-023095-4dannjjm 5187 22 chain chain NN cord-023095-4dannjjm 5187 23 reaction reaction NN cord-023095-4dannjjm 5187 24 ( ( -LRB- cord-023095-4dannjjm 5187 25 qRT qRT NNP cord-023095-4dannjjm 5187 26 - - HYPH cord-023095-4dannjjm 5187 27 PCR PCR NNP cord-023095-4dannjjm 5187 28 ) ) -RRB- cord-023095-4dannjjm 5187 29 with with IN cord-023095-4dannjjm 5187 30 either either DT cord-023095-4dannjjm 5187 31 target target NN cord-023095-4dannjjm 5187 32 gene gene NN cord-023095-4dannjjm 5187 33 ALP ALP NNP cord-023095-4dannjjm 5187 34 ( ( -LRB- cord-023095-4dannjjm 5187 35 aim aim NNP cord-023095-4dannjjm 5187 36 1 1 CD cord-023095-4dannjjm 5187 37 ) ) -RRB- cord-023095-4dannjjm 5187 38 , , , cord-023095-4dannjjm 5187 39 or or CC cord-023095-4dannjjm 5187 40 target target NN cord-023095-4dannjjm 5187 41 gene gene NN cord-023095-4dannjjm 5187 42 b b NNP cord-023095-4dannjjm 5187 43 - - : cord-023095-4dannjjm 5187 44 catenin catenin NNP cord-023095-4dannjjm 5187 45 ( ( -LRB- cord-023095-4dannjjm 5187 46 aim aim VB cord-023095-4dannjjm 5187 47 2 2 CD cord-023095-4dannjjm 5187 48 ) ) -RRB- cord-023095-4dannjjm 5187 49 . . . cord-023095-4dannjjm 5188 1 Additionally additionally RB cord-023095-4dannjjm 5188 2 , , , cord-023095-4dannjjm 5188 3 b b NN cord-023095-4dannjjm 5188 4 - - HYPH cord-023095-4dannjjm 5188 5 catenin catenin NN cord-023095-4dannjjm 5188 6 expression expression NN cord-023095-4dannjjm 5188 7 was be VBD cord-023095-4dannjjm 5188 8 analyzed analyze VBN cord-023095-4dannjjm 5188 9 by by IN cord-023095-4dannjjm 5188 10 Western western JJ cord-023095-4dannjjm 5188 11 blot blot NN cord-023095-4dannjjm 5188 12 . . . cord-023095-4dannjjm 5189 1 QPCR QPCR NNP cord-023095-4dannjjm 5189 2 data datum NNS cord-023095-4dannjjm 5189 3 for for IN cord-023095-4dannjjm 5189 4 bcatenin bcatenin NNP cord-023095-4dannjjm 5189 5 and and CC cord-023095-4dannjjm 5189 6 ALP ALP NNP cord-023095-4dannjjm 5189 7 expression expression NN cord-023095-4dannjjm 5189 8 were be VBD cord-023095-4dannjjm 5189 9 normalized normalize VBN cord-023095-4dannjjm 5189 10 to to IN cord-023095-4dannjjm 5189 11 18S 18S NNP cord-023095-4dannjjm 5189 12 , , , cord-023095-4dannjjm 5189 13 and and CC cord-023095-4dannjjm 5189 14 relative relative JJ cord-023095-4dannjjm 5189 15 expression expression NN cord-023095-4dannjjm 5189 16 was be VBD cord-023095-4dannjjm 5189 17 calculated calculate VBN cord-023095-4dannjjm 5189 18 by by IN cord-023095-4dannjjm 5189 19 the the DT cord-023095-4dannjjm 5189 20 DDCt DDCt NNS cord-023095-4dannjjm 5189 21 method method NN cord-023095-4dannjjm 5189 22 . . . cord-023095-4dannjjm 5190 1 The the DT cord-023095-4dannjjm 5190 2 relative relative JJ cord-023095-4dannjjm 5190 3 expression expression NN cord-023095-4dannjjm 5190 4 of of IN cord-023095-4dannjjm 5190 5 cellular cellular JJ cord-023095-4dannjjm 5190 6 ALP ALP NNP cord-023095-4dannjjm 5190 7 was be VBD cord-023095-4dannjjm 5190 8 higher high JJR cord-023095-4dannjjm 5190 9 in in IN cord-023095-4dannjjm 5190 10 high high JJ cord-023095-4dannjjm 5190 11 serum serum NN cord-023095-4dannjjm 5190 12 ALP alp NN cord-023095-4dannjjm 5190 13 samples sample NNS cord-023095-4dannjjm 5190 14 compared compare VBN cord-023095-4dannjjm 5190 15 to to IN cord-023095-4dannjjm 5190 16 normal normal JJ cord-023095-4dannjjm 5190 17 serum serum NN cord-023095-4dannjjm 5190 18 ALP alp NN cord-023095-4dannjjm 5190 19 samples sample NNS cord-023095-4dannjjm 5190 20 : : : cord-023095-4dannjjm 5190 21 44.74 44.74 CD cord-023095-4dannjjm 5190 22 AE AE NNP cord-023095-4dannjjm 5190 23 22.04 22.04 CD cord-023095-4dannjjm 5191 1 ( ( -LRB- cord-023095-4dannjjm 5191 2 mean mean VB cord-023095-4dannjjm 5191 3 relative relative JJ cord-023095-4dannjjm 5191 4 expression expression NN cord-023095-4dannjjm 5191 5 AE AE NNP cord-023095-4dannjjm 5191 6 standard standard JJ cord-023095-4dannjjm 5191 7 deviation deviation NN cord-023095-4dannjjm 5191 8 ; ; : cord-023095-4dannjjm 5191 9 p p NN cord-023095-4dannjjm 5191 10 o o CD cord-023095-4dannjjm 5191 11 0.001 0.001 CD cord-023095-4dannjjm 5191 12 ) ) -RRB- cord-023095-4dannjjm 5191 13 . . . cord-023095-4dannjjm 5192 1 Further further RB cord-023095-4dannjjm 5192 2 , , , cord-023095-4dannjjm 5192 3 the the DT cord-023095-4dannjjm 5192 4 relative relative JJ cord-023095-4dannjjm 5192 5 expression expression NN cord-023095-4dannjjm 5192 6 of of IN cord-023095-4dannjjm 5192 7 b b NN cord-023095-4dannjjm 5192 8 - - HYPH cord-023095-4dannjjm 5192 9 catenin catenin NNP cord-023095-4dannjjm 5192 10 was be VBD cord-023095-4dannjjm 5192 11 also also RB cord-023095-4dannjjm 5192 12 increased increase VBN cord-023095-4dannjjm 5192 13 ; ; : cord-023095-4dannjjm 5192 14 b b LS cord-023095-4dannjjm 5192 15 - - HYPH cord-023095-4dannjjm 5192 16 catenin catenin NN cord-023095-4dannjjm 5192 17 expression expression NN cord-023095-4dannjjm 5192 18 of of IN cord-023095-4dannjjm 5192 19 high high JJ cord-023095-4dannjjm 5192 20 serum serum NN cord-023095-4dannjjm 5192 21 ALP alp NN cord-023095-4dannjjm 5192 22 samples sample NNS cord-023095-4dannjjm 5192 23 relative relative JJ cord-023095-4dannjjm 5192 24 to to IN cord-023095-4dannjjm 5192 25 low low JJ cord-023095-4dannjjm 5192 26 serum serum NN cord-023095-4dannjjm 5192 27 ALP alp NN cord-023095-4dannjjm 5192 28 samples sample NNS cord-023095-4dannjjm 5192 29 was be VBD cord-023095-4dannjjm 5192 30 24.57 24.57 CD cord-023095-4dannjjm 5192 31 AE AE NNP cord-023095-4dannjjm 5192 32 11.41 11.41 CD cord-023095-4dannjjm 5193 1 ( ( -LRB- cord-023095-4dannjjm 5193 2 p p NN cord-023095-4dannjjm 5193 3 o o CD cord-023095-4dannjjm 5193 4 0.001 0.001 CD cord-023095-4dannjjm 5193 5 ) ) -RRB- cord-023095-4dannjjm 5193 6 , , , cord-023095-4dannjjm 5193 7 which which WDT cord-023095-4dannjjm 5193 8 is be VBZ cord-023095-4dannjjm 5193 9 also also RB cord-023095-4dannjjm 5193 10 seen see VBN cord-023095-4dannjjm 5193 11 by by IN cord-023095-4dannjjm 5193 12 Western western JJ cord-023095-4dannjjm 5193 13 blot blot NN cord-023095-4dannjjm 5193 14 . . . cord-023095-4dannjjm 5194 1 This this DT cord-023095-4dannjjm 5194 2 study study NN cord-023095-4dannjjm 5194 3 begins begin VBZ cord-023095-4dannjjm 5194 4 to to TO cord-023095-4dannjjm 5194 5 clarify clarify VB cord-023095-4dannjjm 5194 6 the the DT cord-023095-4dannjjm 5194 7 mechanism mechanism NN cord-023095-4dannjjm 5194 8 behind behind IN cord-023095-4dannjjm 5194 9 high high JJ cord-023095-4dannjjm 5194 10 serum serum NN cord-023095-4dannjjm 5194 11 ALP ALP NNP cord-023095-4dannjjm 5194 12 in in IN cord-023095-4dannjjm 5194 13 canine canine JJ cord-023095-4dannjjm 5194 14 OSA OSA NNP cord-023095-4dannjjm 5194 15 , , , cord-023095-4dannjjm 5194 16 and and CC cord-023095-4dannjjm 5194 17 suggests suggest VBZ cord-023095-4dannjjm 5194 18 the the DT cord-023095-4dannjjm 5194 19 Wnt Wnt NNP cord-023095-4dannjjm 5194 20 signaling signal VBG cord-023095-4dannjjm 5194 21 pathway pathway NN cord-023095-4dannjjm 5194 22 may may MD cord-023095-4dannjjm 5194 23 be be VB cord-023095-4dannjjm 5194 24 active active JJ cord-023095-4dannjjm 5194 25 in in IN cord-023095-4dannjjm 5194 26 this this DT cord-023095-4dannjjm 5194 27 population population NN cord-023095-4dannjjm 5194 28 of of IN cord-023095-4dannjjm 5194 29 patients patient NNS cord-023095-4dannjjm 5194 30 . . . cord-023095-4dannjjm 5195 1 Further further JJ cord-023095-4dannjjm 5195 2 work work NN cord-023095-4dannjjm 5195 3 will will MD cord-023095-4dannjjm 5195 4 focus focus VB cord-023095-4dannjjm 5195 5 on on IN cord-023095-4dannjjm 5195 6 elucidating elucidate VBG cord-023095-4dannjjm 5195 7 the the DT cord-023095-4dannjjm 5195 8 role role NN cord-023095-4dannjjm 5195 9 active active JJ cord-023095-4dannjjm 5195 10 Wnt Wnt NNP cord-023095-4dannjjm 5195 11 signaling signal VBG cord-023095-4dannjjm 5195 12 plays play NNS cord-023095-4dannjjm 5195 13 in in IN cord-023095-4dannjjm 5195 14 the the DT cord-023095-4dannjjm 5195 15 biology biology NN cord-023095-4dannjjm 5195 16 of of IN cord-023095-4dannjjm 5195 17 OSA OSA NNP cord-023095-4dannjjm 5195 18 . . . cord-023095-4dannjjm 5196 1 In in IN cord-023095-4dannjjm 5196 2 the the DT cord-023095-4dannjjm 5196 3 future future NN cord-023095-4dannjjm 5196 4 , , , cord-023095-4dannjjm 5196 5 serum serum NN cord-023095-4dannjjm 5196 6 ALP alp NN cord-023095-4dannjjm 5196 7 status status NN cord-023095-4dannjjm 5196 8 of of IN cord-023095-4dannjjm 5196 9 OSA OSA NNP cord-023095-4dannjjm 5196 10 patients patient NNS cord-023095-4dannjjm 5196 11 may may MD cord-023095-4dannjjm 5196 12 help help VB cord-023095-4dannjjm 5196 13 identify identify VB cord-023095-4dannjjm 5196 14 patients patient NNS cord-023095-4dannjjm 5196 15 that that WDT cord-023095-4dannjjm 5196 16 would would MD cord-023095-4dannjjm 5196 17 benefit benefit VB cord-023095-4dannjjm 5196 18 from from IN cord-023095-4dannjjm 5196 19 therapies therapy NNS cord-023095-4dannjjm 5196 20 targeting target VBG cord-023095-4dannjjm 5196 21 this this DT cord-023095-4dannjjm 5196 22 pathway pathway NN cord-023095-4dannjjm 5196 23 . . . cord-023095-4dannjjm 5197 1 Accurate accurate JJ cord-023095-4dannjjm 5197 2 assessment assessment NN cord-023095-4dannjjm 5197 3 of of IN cord-023095-4dannjjm 5197 4 abdominal abdominal JJ cord-023095-4dannjjm 5197 5 lymph lymph NN cord-023095-4dannjjm 5197 6 node node NN cord-023095-4dannjjm 5197 7 status status NN cord-023095-4dannjjm 5197 8 is be VBZ cord-023095-4dannjjm 5197 9 of of IN cord-023095-4dannjjm 5197 10 vital vital JJ cord-023095-4dannjjm 5197 11 importance importance NN cord-023095-4dannjjm 5197 12 for for IN cord-023095-4dannjjm 5197 13 appropriate appropriate JJ cord-023095-4dannjjm 5197 14 treatment treatment NN cord-023095-4dannjjm 5197 15 planning planning NN cord-023095-4dannjjm 5197 16 and and CC cord-023095-4dannjjm 5197 17 determining determine VBG cord-023095-4dannjjm 5197 18 prognosis prognosis NN cord-023095-4dannjjm 5197 19 in in IN cord-023095-4dannjjm 5197 20 dogs dog NNS cord-023095-4dannjjm 5197 21 with with IN cord-023095-4dannjjm 5197 22 apocrine apocrine JJ cord-023095-4dannjjm 5197 23 gland gland NN cord-023095-4dannjjm 5197 24 adenocarcinoma adenocarcinoma NN cord-023095-4dannjjm 5197 25 of of IN cord-023095-4dannjjm 5197 26 the the DT cord-023095-4dannjjm 5197 27 anal anal JJ cord-023095-4dannjjm 5197 28 sac sac NN cord-023095-4dannjjm 5197 29 ( ( -LRB- cord-023095-4dannjjm 5197 30 AGAAS AGAAS NNP cord-023095-4dannjjm 5197 31 ) ) -RRB- cord-023095-4dannjjm 5197 32 . . . cord-023095-4dannjjm 5198 1 Pretreatment pretreatment JJ cord-023095-4dannjjm 5198 2 knowledge knowledge NN cord-023095-4dannjjm 5198 3 of of IN cord-023095-4dannjjm 5198 4 lymph lymph NN cord-023095-4dannjjm 5198 5 node node NN cord-023095-4dannjjm 5198 6 status status NN cord-023095-4dannjjm 5198 7 is be VBZ cord-023095-4dannjjm 5198 8 helpful helpful JJ cord-023095-4dannjjm 5198 9 for for IN cord-023095-4dannjjm 5198 10 determining determine VBG cord-023095-4dannjjm 5198 11 prognosis prognosis NN cord-023095-4dannjjm 5198 12 and and CC cord-023095-4dannjjm 5198 13 planning plan VBG cord-023095-4dannjjm 5198 14 the the DT cord-023095-4dannjjm 5198 15 optimal optimal JJ cord-023095-4dannjjm 5198 16 extent extent NN cord-023095-4dannjjm 5198 17 of of IN cord-023095-4dannjjm 5198 18 lymphadenectomy lymphadenectomy NN cord-023095-4dannjjm 5198 19 . . . cord-023095-4dannjjm 5199 1 In in IN cord-023095-4dannjjm 5199 2 addition addition NN cord-023095-4dannjjm 5199 3 , , , cord-023095-4dannjjm 5199 4 pretreatment pretreatment NN cord-023095-4dannjjm 5199 5 knowledge knowledge NN cord-023095-4dannjjm 5199 6 of of IN cord-023095-4dannjjm 5199 7 lymph lymph NN cord-023095-4dannjjm 5199 8 node node NN cord-023095-4dannjjm 5199 9 status status NN cord-023095-4dannjjm 5199 10 may may MD cord-023095-4dannjjm 5199 11 help help VB cord-023095-4dannjjm 5199 12 in in IN cord-023095-4dannjjm 5199 13 selecting select VBG cord-023095-4dannjjm 5199 14 patients patient NNS cord-023095-4dannjjm 5199 15 who who WP cord-023095-4dannjjm 5199 16 might may MD cord-023095-4dannjjm 5199 17 benefit benefit VB cord-023095-4dannjjm 5199 18 from from IN cord-023095-4dannjjm 5199 19 adjuvant adjuvant JJ cord-023095-4dannjjm 5199 20 chemotherapy chemotherapy NN cord-023095-4dannjjm 5199 21 and and CC cord-023095-4dannjjm 5199 22 radiation radiation NN cord-023095-4dannjjm 5199 23 therapy therapy NN cord-023095-4dannjjm 5199 24 . . . cord-023095-4dannjjm 5200 1 Abdominal abdominal JJ cord-023095-4dannjjm 5200 2 ultrasound ultrasound NN cord-023095-4dannjjm 5200 3 is be VBZ cord-023095-4dannjjm 5200 4 currently currently RB cord-023095-4dannjjm 5200 5 the the DT cord-023095-4dannjjm 5200 6 most most RBS cord-023095-4dannjjm 5200 7 commonly commonly RB cord-023095-4dannjjm 5200 8 employed employ VBN cord-023095-4dannjjm 5200 9 test test NN cord-023095-4dannjjm 5200 10 to to TO cord-023095-4dannjjm 5200 11 screen screen VB cord-023095-4dannjjm 5200 12 for for IN cord-023095-4dannjjm 5200 13 abdominal abdominal JJ cord-023095-4dannjjm 5200 14 lymphadenopathy lymphadenopathy NN cord-023095-4dannjjm 5200 15 in in IN cord-023095-4dannjjm 5200 16 dogs dog NNS cord-023095-4dannjjm 5200 17 with with IN cord-023095-4dannjjm 5200 18 AGAAS agaa NNS cord-023095-4dannjjm 5200 19 . . . cord-023095-4dannjjm 5201 1 Imaging imaging NN cord-023095-4dannjjm 5201 2 studies study NNS cord-023095-4dannjjm 5201 3 in in IN cord-023095-4dannjjm 5201 4 people people NNS cord-023095-4dannjjm 5201 5 indicate indicate VBP cord-023095-4dannjjm 5201 6 that that IN cord-023095-4dannjjm 5201 7 magnetic magnetic JJ cord-023095-4dannjjm 5201 8 resonance resonance NN cord-023095-4dannjjm 5201 9 imaging imaging NN cord-023095-4dannjjm 5201 10 ( ( -LRB- cord-023095-4dannjjm 5201 11 To to TO cord-023095-4dannjjm 5201 12 determine determine VB cord-023095-4dannjjm 5201 13 and and CC cord-023095-4dannjjm 5201 14 compare compare VB cord-023095-4dannjjm 5201 15 the the DT cord-023095-4dannjjm 5201 16 plasma plasma NN cord-023095-4dannjjm 5201 17 concentration concentration NN cord-023095-4dannjjm 5201 18 of of IN cord-023095-4dannjjm 5201 19 cyclophosphamide cyclophosphamide NN cord-023095-4dannjjm 5201 20 and and CC cord-023095-4dannjjm 5201 21 its -PRON- PRP$ cord-023095-4dannjjm 5201 22 metabolite metabolite JJ cord-023095-4dannjjm 5201 23 4-OHCP 4-ohcp NN cord-023095-4dannjjm 5201 24 , , , cord-023095-4dannjjm 5201 25 within within IN cord-023095-4dannjjm 5201 26 the the DT cord-023095-4dannjjm 5201 27 plasma plasma NN cord-023095-4dannjjm 5201 28 of of IN cord-023095-4dannjjm 5201 29 lymphoma lymphoma NN cord-023095-4dannjjm 5201 30 bearing bear VBG cord-023095-4dannjjm 5201 31 dogs dog NNS cord-023095-4dannjjm 5201 32 being be VBG cord-023095-4dannjjm 5201 33 treated treat VBN cord-023095-4dannjjm 5201 34 with with IN cord-023095-4dannjjm 5201 35 either either CC cord-023095-4dannjjm 5201 36 oral oral JJ cord-023095-4dannjjm 5201 37 or or CC cord-023095-4dannjjm 5201 38 intravenous intravenous JJ cord-023095-4dannjjm 5201 39 cyclophosphamide cyclophosphamide NN cord-023095-4dannjjm 5201 40 . . . cord-023095-4dannjjm 5202 1 In in IN cord-023095-4dannjjm 5202 2 this this DT cord-023095-4dannjjm 5202 3 prospective prospective JJ cord-023095-4dannjjm 5202 4 study study NN cord-023095-4dannjjm 5202 5 , , , cord-023095-4dannjjm 5202 6 patients patient NNS cord-023095-4dannjjm 5202 7 were be VBD cord-023095-4dannjjm 5202 8 randomly randomly RB cord-023095-4dannjjm 5202 9 assigned assign VBN cord-023095-4dannjjm 5202 10 to to IN cord-023095-4dannjjm 5202 11 either either CC cord-023095-4dannjjm 5202 12 receive receive VBP cord-023095-4dannjjm 5202 13 oral oral JJ cord-023095-4dannjjm 5202 14 or or CC cord-023095-4dannjjm 5202 15 intravenous intravenous JJ cord-023095-4dannjjm 5202 16 cyclophosphamide cyclophosphamide NN cord-023095-4dannjjm 5202 17 , , , cord-023095-4dannjjm 5202 18 at at IN cord-023095-4dannjjm 5202 19 a a DT cord-023095-4dannjjm 5202 20 dose dose NN cord-023095-4dannjjm 5202 21 of of IN cord-023095-4dannjjm 5202 22 250 250 CD cord-023095-4dannjjm 5202 23 mg mg NNP cord-023095-4dannjjm 5202 24 / / SYM cord-023095-4dannjjm 5202 25 m2 m2 NNP cord-023095-4dannjjm 5202 26 . . . cord-023095-4dannjjm 5203 1 Based base VBN cord-023095-4dannjjm 5203 2 on on IN cord-023095-4dannjjm 5203 3 a a DT cord-023095-4dannjjm 5203 4 priori priori FW cord-023095-4dannjjm 5203 5 power power NN cord-023095-4dannjjm 5203 6 calculation calculation NN cord-023095-4dannjjm 5203 7 eight eight CD cord-023095-4dannjjm 5203 8 patients patient NNS cord-023095-4dannjjm 5203 9 per per IN cord-023095-4dannjjm 5203 10 treatment treatment NN cord-023095-4dannjjm 5203 11 group group NN cord-023095-4dannjjm 5203 12 were be VBD cord-023095-4dannjjm 5203 13 enrolled enrol VBN cord-023095-4dannjjm 5203 14 . . . cord-023095-4dannjjm 5204 1 Plasma plasma NN cord-023095-4dannjjm 5204 2 was be VBD cord-023095-4dannjjm 5204 3 obtained obtain VBN cord-023095-4dannjjm 5204 4 at at IN cord-023095-4dannjjm 5204 5 times time NNS cord-023095-4dannjjm 5204 6 0 0 CD cord-023095-4dannjjm 5204 7 , , , cord-023095-4dannjjm 5204 8 15 15 CD cord-023095-4dannjjm 5204 9 , , , cord-023095-4dannjjm 5204 10 30 30 CD cord-023095-4dannjjm 5204 11 , , , cord-023095-4dannjjm 5204 12 60 60 CD cord-023095-4dannjjm 5204 13 minutes minute NNS cord-023095-4dannjjm 5204 14 , , , cord-023095-4dannjjm 5204 15 and and CC cord-023095-4dannjjm 5204 16 then then RB cord-023095-4dannjjm 5204 17 at at IN cord-023095-4dannjjm 5204 18 2 2 CD cord-023095-4dannjjm 5204 19 , , , cord-023095-4dannjjm 5204 20 4 4 CD cord-023095-4dannjjm 5204 21 , , , cord-023095-4dannjjm 5204 22 6 6 CD cord-023095-4dannjjm 5204 23 , , , cord-023095-4dannjjm 5204 24 8 8 CD cord-023095-4dannjjm 5204 25 , , , cord-023095-4dannjjm 5204 26 24 24 CD cord-023095-4dannjjm 5204 27 hours hour NNS cord-023095-4dannjjm 5204 28 post post NN cord-023095-4dannjjm 5204 29 administration administration NN cord-023095-4dannjjm 5204 30 for for IN cord-023095-4dannjjm 5204 31 evaluation evaluation NN cord-023095-4dannjjm 5204 32 of of IN cord-023095-4dannjjm 5204 33 4-OHCP 4-ohcp CD cord-023095-4dannjjm 5204 34 concentrations concentration NNS cord-023095-4dannjjm 5204 35 by by IN cord-023095-4dannjjm 5204 36 liquid liquid JJ cord-023095-4dannjjm 5204 37 chromatography chromatography NN cord-023095-4dannjjm 5204 38 - - HYPH cord-023095-4dannjjm 5204 39 dual dual JJ cord-023095-4dannjjm 5204 40 mass mass NN cord-023095-4dannjjm 5204 41 spectrometry spectrometry NN cord-023095-4dannjjm 5204 42 ( ( -LRB- cord-023095-4dannjjm 5204 43 LC LC NNP cord-023095-4dannjjm 5204 44 / / SYM cord-023095-4dannjjm 5204 45 MS MS NNP cord-023095-4dannjjm 5204 46 / / SYM cord-023095-4dannjjm 5204 47 MS MS NNP cord-023095-4dannjjm 5204 48 ) ) -RRB- cord-023095-4dannjjm 5204 49 . . . cord-023095-4dannjjm 5205 1 Average average JJ cord-023095-4dannjjm 5205 2 values value NNS cord-023095-4dannjjm 5205 3 were be VBD cord-023095-4dannjjm 5205 4 obtained obtain VBN cord-023095-4dannjjm 5205 5 for for IN cord-023095-4dannjjm 5205 6 both both CC cord-023095-4dannjjm 5205 7 cyclophosphamide cyclophosphamide IN cord-023095-4dannjjm 5205 8 and and CC cord-023095-4dannjjm 5205 9 4-OHCP 4-ohcp CD cord-023095-4dannjjm 5205 10 concentrations concentration NNS cord-023095-4dannjjm 5205 11 within within IN cord-023095-4dannjjm 5205 12 the the DT cord-023095-4dannjjm 5205 13 plasma plasma NN cord-023095-4dannjjm 5205 14 of of IN cord-023095-4dannjjm 5205 15 both both DT cord-023095-4dannjjm 5205 16 groups group NNS cord-023095-4dannjjm 5205 17 . . . cord-023095-4dannjjm 5206 1 The the DT cord-023095-4dannjjm 5206 2 following follow VBG cord-023095-4dannjjm 5206 3 values value NNS cord-023095-4dannjjm 5206 4 were be VBD cord-023095-4dannjjm 5206 5 obtained obtain VBN cord-023095-4dannjjm 5206 6 , , , cord-023095-4dannjjm 5206 7 half half JJ cord-023095-4dannjjm 5206 8 life life NN cord-023095-4dannjjm 5206 9 ( ( -LRB- cord-023095-4dannjjm 5206 10 HL HL NNP cord-023095-4dannjjm 5206 11 ) ) -RRB- cord-023095-4dannjjm 5206 12 , , , cord-023095-4dannjjm 5206 13 time time NN cord-023095-4dannjjm 5206 14 to to IN cord-023095-4dannjjm 5206 15 maximum maximum VB cord-023095-4dannjjm 5206 16 concentration concentration NN cord-023095-4dannjjm 5206 17 ( ( -LRB- cord-023095-4dannjjm 5206 18 Tmax Tmax NNP cord-023095-4dannjjm 5206 19 ) ) -RRB- cord-023095-4dannjjm 5206 20 , , , cord-023095-4dannjjm 5206 21 maximum maximum JJ cord-023095-4dannjjm 5206 22 concentration concentration NN cord-023095-4dannjjm 5206 23 ( ( -LRB- cord-023095-4dannjjm 5206 24 Cmax Cmax NNP cord-023095-4dannjjm 5206 25 ) ) -RRB- cord-023095-4dannjjm 5206 26 , , , cord-023095-4dannjjm 5206 27 and and CC cord-023095-4dannjjm 5206 28 area area NN cord-023095-4dannjjm 5206 29 under under IN cord-023095-4dannjjm 5206 30 the the DT cord-023095-4dannjjm 5206 31 curve curve NN cord-023095-4dannjjm 5206 32 ( ( -LRB- cord-023095-4dannjjm 5206 33 AUC AUC NNP cord-023095-4dannjjm 5206 34 ) ) -RRB- cord-023095-4dannjjm 5206 35 . . . cord-023095-4dannjjm 5207 1 The the DT cord-023095-4dannjjm 5207 2 Mann Mann NNP cord-023095-4dannjjm 5207 3 - - HYPH cord-023095-4dannjjm 5207 4 Whitney Whitney NNP cord-023095-4dannjjm 5207 5 statistical statistical JJ cord-023095-4dannjjm 5207 6 test test NN cord-023095-4dannjjm 5207 7 was be VBD cord-023095-4dannjjm 5207 8 used use VBN cord-023095-4dannjjm 5207 9 to to TO cord-023095-4dannjjm 5207 10 compare compare VB cord-023095-4dannjjm 5207 11 the the DT cord-023095-4dannjjm 5207 12 groups group NNS cord-023095-4dannjjm 5207 13 . . . cord-023095-4dannjjm 5208 1 The the DT cord-023095-4dannjjm 5208 2 AUC AUC NNP cord-023095-4dannjjm 5208 3 for for IN cord-023095-4dannjjm 5208 4 cyclophosphamide cyclophosphamide NN cord-023095-4dannjjm 5208 5 was be VBD cord-023095-4dannjjm 5208 6 statistically statistically RB cord-023095-4dannjjm 5208 7 significant significant JJ cord-023095-4dannjjm 5209 1 ( ( -LRB- cord-023095-4dannjjm 5209 2 P p NN cord-023095-4dannjjm 5209 3 o o NN cord-023095-4dannjjm 5209 4 0.05 0.05 CD cord-023095-4dannjjm 5209 5 ) ) -RRB- cord-023095-4dannjjm 5209 6 when when WRB cord-023095-4dannjjm 5209 7 compared compare VBN cord-023095-4dannjjm 5209 8 between between IN cord-023095-4dannjjm 5209 9 the the DT cord-023095-4dannjjm 5209 10 two two CD cord-023095-4dannjjm 5209 11 groups group NNS cord-023095-4dannjjm 5209 12 . . . cord-023095-4dannjjm 5210 1 The the DT cord-023095-4dannjjm 5210 2 AUC AUC NNP cord-023095-4dannjjm 5210 3 for for IN cord-023095-4dannjjm 5210 4 4-OHCP 4-OHCP NNP cord-023095-4dannjjm 5210 5 was be VBD cord-023095-4dannjjm 5210 6 not not RB cord-023095-4dannjjm 5210 7 statistically statistically RB cord-023095-4dannjjm 5210 8 significant significant JJ cord-023095-4dannjjm 5210 9 between between IN cord-023095-4dannjjm 5210 10 the the DT cord-023095-4dannjjm 5210 11 groups group NNS cord-023095-4dannjjm 5210 12 . . . cord-023095-4dannjjm 5211 1 The the DT cord-023095-4dannjjm 5211 2 difference difference NN cord-023095-4dannjjm 5211 3 between between IN cord-023095-4dannjjm 5211 4 Cmax Cmax NNP cord-023095-4dannjjm 5211 5 for for IN cord-023095-4dannjjm 5211 6 cyclophosphamide cyclophosphamide NN cord-023095-4dannjjm 5211 7 and and CC cord-023095-4dannjjm 5211 8 4-OHCP 4-ohcp NN cord-023095-4dannjjm 5211 9 was be VBD cord-023095-4dannjjm 5211 10 statistically statistically RB cord-023095-4dannjjm 5211 11 significantly significantly RB cord-023095-4dannjjm 5211 12 ( ( -LRB- cord-023095-4dannjjm 5211 13 P p NN cord-023095-4dannjjm 5211 14 o o NN cord-023095-4dannjjm 5211 15 0.05 0.05 CD cord-023095-4dannjjm 5211 16 ) ) -RRB- cord-023095-4dannjjm 5211 17 between between IN cord-023095-4dannjjm 5211 18 the the DT cord-023095-4dannjjm 5211 19 groups group NNS cord-023095-4dannjjm 5211 20 . . . cord-023095-4dannjjm 5212 1 Although although IN cord-023095-4dannjjm 5212 2 the the DT cord-023095-4dannjjm 5212 3 AUC AUC NNP cord-023095-4dannjjm 5212 4 for for IN cord-023095-4dannjjm 5212 5 cyclophosphamide cyclophosphamide NN cord-023095-4dannjjm 5212 6 was be VBD cord-023095-4dannjjm 5212 7 statistically statistically RB cord-023095-4dannjjm 5212 8 significant significant JJ cord-023095-4dannjjm 5212 9 between between IN cord-023095-4dannjjm 5212 10 the the DT cord-023095-4dannjjm 5212 11 two two CD cord-023095-4dannjjm 5212 12 groups group NNS cord-023095-4dannjjm 5212 13 , , , cord-023095-4dannjjm 5212 14 the the DT cord-023095-4dannjjm 5212 15 AUC AUC NNP cord-023095-4dannjjm 5212 16 for for IN cord-023095-4dannjjm 5212 17 the the DT cord-023095-4dannjjm 5212 18 active active JJ cord-023095-4dannjjm 5212 19 metabolite metabolite NN cord-023095-4dannjjm 5212 20 4-OHCP 4-ohcp NN cord-023095-4dannjjm 5212 21 was be VBD cord-023095-4dannjjm 5212 22 not not RB cord-023095-4dannjjm 5212 23 different different JJ cord-023095-4dannjjm 5212 24 when when WRB cord-023095-4dannjjm 5212 25 administered administer VBN cord-023095-4dannjjm 5212 26 intravenously intravenously RB cord-023095-4dannjjm 5212 27 or or CC cord-023095-4dannjjm 5212 28 orally orally RB cord-023095-4dannjjm 5212 29 . . . cord-023095-4dannjjm 5213 1 Thus thus RB cord-023095-4dannjjm 5213 2 drug drug NN cord-023095-4dannjjm 5213 3 exposure exposure NN cord-023095-4dannjjm 5213 4 to to IN cord-023095-4dannjjm 5213 5 the the DT cord-023095-4dannjjm 5213 6 active active JJ cord-023095-4dannjjm 5213 7 metabolite metabolite NN cord-023095-4dannjjm 5213 8 of of IN cord-023095-4dannjjm 5213 9 cyclophosphamide cyclophosphamide NN cord-023095-4dannjjm 5213 10 is be VBZ cord-023095-4dannjjm 5213 11 the the DT cord-023095-4dannjjm 5213 12 same same JJ cord-023095-4dannjjm 5213 13 when when WRB cord-023095-4dannjjm 5213 14 administered administer VBN cord-023095-4dannjjm 5213 15 intravenously intravenously RB cord-023095-4dannjjm 5213 16 or or CC cord-023095-4dannjjm 5213 17 orally orally RB cord-023095-4dannjjm 5213 18 . . . cord-023095-4dannjjm 5214 1 Previously previously RB cord-023095-4dannjjm 5214 2 The the DT cord-023095-4dannjjm 5214 3 percentage percentage NN cord-023095-4dannjjm 5214 4 of of IN cord-023095-4dannjjm 5214 5 successful successful JJ cord-023095-4dannjjm 5214 6 intraosseous intraosseous JJ cord-023095-4dannjjm 5214 7 ( ( -LRB- cord-023095-4dannjjm 5214 8 IO IO NNP cord-023095-4dannjjm 5214 9 ) ) -RRB- cord-023095-4dannjjm 5214 10 catheter catheter NN cord-023095-4dannjjm 5214 11 insertions insertion NNS cord-023095-4dannjjm 5214 12 , , , cord-023095-4dannjjm 5214 13 insertion insertion NN cord-023095-4dannjjm 5214 14 times time NNS cord-023095-4dannjjm 5214 15 , , , cord-023095-4dannjjm 5214 16 and and CC cord-023095-4dannjjm 5214 17 ' ' '' cord-023095-4dannjjm 5214 18 ' ' '' cord-023095-4dannjjm 5214 19 ease ease NN cord-023095-4dannjjm 5214 20 of of IN cord-023095-4dannjjm 5214 21 use use NN cord-023095-4dannjjm 5214 22 ' ' '' cord-023095-4dannjjm 5214 23 ' ' '' cord-023095-4dannjjm 5214 24 scores score NNS cord-023095-4dannjjm 5214 25 using use VBG cord-023095-4dannjjm 5214 26 the the DT cord-023095-4dannjjm 5214 27 EZ EZ NNP cord-023095-4dannjjm 5214 28 - - HYPH cord-023095-4dannjjm 5214 29 IO IO NNP cord-023095-4dannjjm 5214 30 G3 G3 NNP cord-023095-4dannjjm 5214 31 power power NN cord-023095-4dannjjm 5214 32 driver driver NN cord-023095-4dannjjm 5214 33 by by IN cord-023095-4dannjjm 5214 34 a a DT cord-023095-4dannjjm 5214 35 wide wide JJ cord-023095-4dannjjm 5214 36 spectrum spectrum NN cord-023095-4dannjjm 5214 37 of of IN cord-023095-4dannjjm 5214 38 novice novice JJ cord-023095-4dannjjm 5214 39 participants participant NNS cord-023095-4dannjjm 5214 40 in in IN cord-023095-4dannjjm 5214 41 feline feline JJ cord-023095-4dannjjm 5214 42 cadavers cadaver NNS cord-023095-4dannjjm 5214 43 were be VBD cord-023095-4dannjjm 5214 44 evaluated evaluate VBN cord-023095-4dannjjm 5214 45 . . . cord-023095-4dannjjm 5215 1 Novice novice JJ cord-023095-4dannjjm 5215 2 users user NNS cord-023095-4dannjjm 5215 3 ' ' POS cord-023095-4dannjjm 5215 4 mean mean JJ cord-023095-4dannjjm 5215 5 IO IO NNP cord-023095-4dannjjm 5215 6 catheter catheter NN cord-023095-4dannjjm 5215 7 insertion insertion NN cord-023095-4dannjjm 5215 8 time time NN cord-023095-4dannjjm 5215 9 using use VBG cord-023095-4dannjjm 5215 10 the the DT cord-023095-4dannjjm 5215 11 EZ EZ NNP cord-023095-4dannjjm 5215 12 - - HYPH cord-023095-4dannjjm 5215 13 IO IO NNP cord-023095-4dannjjm 5215 14 G3 G3 NNP cord-023095-4dannjjm 5215 15 driver driver NN cord-023095-4dannjjm 5215 16 was be VBD cord-023095-4dannjjm 5215 17 also also RB cord-023095-4dannjjm 5215 18 compared compare VBN cord-023095-4dannjjm 5215 19 to to IN cord-023095-4dannjjm 5215 20 the the DT cord-023095-4dannjjm 5215 21 mean mean JJ cord-023095-4dannjjm 5215 22 IV IV NNP cord-023095-4dannjjm 5215 23 catheter catheter NN cord-023095-4dannjjm 5215 24 insertion insertion NN cord-023095-4dannjjm 5215 25 time time NN cord-023095-4dannjjm 5215 26 in in IN cord-023095-4dannjjm 5215 27 normovolemic normovolemic JJ cord-023095-4dannjjm 5215 28 feline feline JJ cord-023095-4dannjjm 5215 29 and and CC cord-023095-4dannjjm 5215 30 canine canine JJ cord-023095-4dannjjm 5215 31 patients patient NNS cord-023095-4dannjjm 5215 32 presented present VBN cord-023095-4dannjjm 5215 33 to to IN cord-023095-4dannjjm 5215 34 the the DT cord-023095-4dannjjm 5215 35 Western Western NNP cord-023095-4dannjjm 5215 36 College College NNP cord-023095-4dannjjm 5215 37 of of IN cord-023095-4dannjjm 5215 38 Veterinary Veterinary NNP cord-023095-4dannjjm 5215 39 Medicine Medicine NNP cord-023095-4dannjjm 5215 40 ( ( -LRB- cord-023095-4dannjjm 5215 41 WCVM WCVM NNP cord-023095-4dannjjm 5215 42 ) ) -RRB- cord-023095-4dannjjm 5216 1 Small Small NNP cord-023095-4dannjjm 5216 2 Animal Animal NNP cord-023095-4dannjjm 5216 3 Hospital Hospital NNP cord-023095-4dannjjm 5216 4 . . . cord-023095-4dannjjm 5217 1 Novice novice JJ cord-023095-4dannjjm 5217 2 users user NNS cord-023095-4dannjjm 5217 3 included include VBD cord-023095-4dannjjm 5217 4 40 40 CD cord-023095-4dannjjm 5217 5 WCVM wcvm JJ cord-023095-4dannjjm 5217 6 personnel personnel NNS cord-023095-4dannjjm 5217 7 ( ( -LRB- cord-023095-4dannjjm 5217 8 8 8 CD cord-023095-4dannjjm 5217 9 technicians technician NNS cord-023095-4dannjjm 5217 10 , , , cord-023095-4dannjjm 5217 11 11 11 CD cord-023095-4dannjjm 5217 12 veterinary veterinary JJ cord-023095-4dannjjm 5217 13 students student NNS cord-023095-4dannjjm 5217 14 , , , cord-023095-4dannjjm 5217 15 5 5 CD cord-023095-4dannjjm 5217 16 interns intern NNS cord-023095-4dannjjm 5217 17 , , , cord-023095-4dannjjm 5217 18 8 8 CD cord-023095-4dannjjm 5217 19 residents resident NNS cord-023095-4dannjjm 5217 20 , , , cord-023095-4dannjjm 5217 21 8 8 CD cord-023095-4dannjjm 5217 22 clinicians clinician NNS cord-023095-4dannjjm 5217 23 ) ) -RRB- cord-023095-4dannjjm 5217 24 . . . cord-023095-4dannjjm 5218 1 After after IN cord-023095-4dannjjm 5218 2 watching watch VBG cord-023095-4dannjjm 5218 3 a a DT cord-023095-4dannjjm 5218 4 5-minute 5-minute CD cord-023095-4dannjjm 5218 5 EZ EZ NNP cord-023095-4dannjjm 5218 6 - - HYPH cord-023095-4dannjjm 5218 7 IO IO NNP cord-023095-4dannjjm 5218 8 G3 G3 NNP cord-023095-4dannjjm 5218 9 training training NN cord-023095-4dannjjm 5218 10 video video NN cord-023095-4dannjjm 5218 11 , , , cord-023095-4dannjjm 5218 12 each each DT cord-023095-4dannjjm 5218 13 participant participant NN cord-023095-4dannjjm 5218 14 inserted insert VBD cord-023095-4dannjjm 5218 15 3 3 CD cord-023095-4dannjjm 5218 16 IO IO NNP cord-023095-4dannjjm 5218 17 catheters catheter NNS cord-023095-4dannjjm 5218 18 using use VBG cord-023095-4dannjjm 5218 19 the the DT cord-023095-4dannjjm 5218 20 EZ EZ NNP cord-023095-4dannjjm 5218 21 - - HYPH cord-023095-4dannjjm 5218 22 IO IO NNP cord-023095-4dannjjm 5218 23 G3 G3 NNP cord-023095-4dannjjm 5218 24 driver driver NN cord-023095-4dannjjm 5218 25 . . . cord-023095-4dannjjm 5219 1 Site site NN cord-023095-4dannjjm 5219 2 ( ( -LRB- cord-023095-4dannjjm 5219 3 proximal proximal JJ cord-023095-4dannjjm 5219 4 humerus humerus NN cord-023095-4dannjjm 5219 5 or or CC cord-023095-4dannjjm 5219 6 trochanteric trochanteric JJ cord-023095-4dannjjm 5219 7 fossa fossa NN cord-023095-4dannjjm 5219 8 of of IN cord-023095-4dannjjm 5219 9 the the DT cord-023095-4dannjjm 5219 10 femur femur NN cord-023095-4dannjjm 5219 11 ) ) -RRB- cord-023095-4dannjjm 5219 12 and and CC cord-023095-4dannjjm 5219 13 side side NN cord-023095-4dannjjm 5219 14 of of IN cord-023095-4dannjjm 5219 15 cat cat NN cord-023095-4dannjjm 5219 16 ( ( -LRB- cord-023095-4dannjjm 5220 1 right right UH cord-023095-4dannjjm 5220 2 or or CC cord-023095-4dannjjm 5220 3 left left RB cord-023095-4dannjjm 5220 4 ) ) -RRB- cord-023095-4dannjjm 5220 5 were be VBD cord-023095-4dannjjm 5220 6 randomized randomize VBN cord-023095-4dannjjm 5220 7 for for IN cord-023095-4dannjjm 5220 8 each each DT cord-023095-4dannjjm 5220 9 attempt attempt NN cord-023095-4dannjjm 5220 10 for for IN cord-023095-4dannjjm 5220 11 each each DT cord-023095-4dannjjm 5220 12 participant participant NN cord-023095-4dannjjm 5220 13 . . . cord-023095-4dannjjm 5221 1 A a DT cord-023095-4dannjjm 5221 2 15 15 CD cord-023095-4dannjjm 5221 3 gauge gauge NN cord-023095-4dannjjm 5221 4 x x SYM cord-023095-4dannjjm 5221 5 15 15 CD cord-023095-4dannjjm 5221 6 mm mm NN cord-023095-4dannjjm 5221 7 long long JJ cord-023095-4dannjjm 5221 8 needle needle NN cord-023095-4dannjjm 5221 9 and and CC cord-023095-4dannjjm 5221 10 a a DT cord-023095-4dannjjm 5221 11 15 15 CD cord-023095-4dannjjm 5221 12 gauge gauge NN cord-023095-4dannjjm 5221 13 x x SYM cord-023095-4dannjjm 5221 14 25 25 CD cord-023095-4dannjjm 5221 15 mm mm CD cord-023095-4dannjjm 5221 16 needle needle NN cord-023095-4dannjjm 5221 17 were be VBD cord-023095-4dannjjm 5221 18 used use VBN cord-023095-4dannjjm 5221 19 for for IN cord-023095-4dannjjm 5221 20 IO IO NNP cord-023095-4dannjjm 5221 21 catheter catheter NN cord-023095-4dannjjm 5221 22 insertion insertion NN cord-023095-4dannjjm 5221 23 in in IN cord-023095-4dannjjm 5221 24 the the DT cord-023095-4dannjjm 5221 25 humerus humerus NN cord-023095-4dannjjm 5221 26 and and CC cord-023095-4dannjjm 5221 27 femur femur NN cord-023095-4dannjjm 5221 28 , , , cord-023095-4dannjjm 5221 29 respectively respectively RB cord-023095-4dannjjm 5221 30 . . . cord-023095-4dannjjm 5222 1 Participants participant NNS cord-023095-4dannjjm 5222 2 then then RB cord-023095-4dannjjm 5222 3 graded grade VBD cord-023095-4dannjjm 5222 4 the the DT cord-023095-4dannjjm 5222 5 ' ' '' cord-023095-4dannjjm 5222 6 ' ' '' cord-023095-4dannjjm 5222 7 ease ease NN cord-023095-4dannjjm 5222 8 of of IN cord-023095-4dannjjm 5222 9 use use NN cord-023095-4dannjjm 5222 10 ' ' '' cord-023095-4dannjjm 5222 11 ' ' '' cord-023095-4dannjjm 5222 12 of of IN cord-023095-4dannjjm 5222 13 the the DT cord-023095-4dannjjm 5222 14 EZ EZ NNP cord-023095-4dannjjm 5222 15 - - HYPH cord-023095-4dannjjm 5222 16 IO IO NNP cord-023095-4dannjjm 5222 17 G3 G3 NNP cord-023095-4dannjjm 5222 18 device device NN cord-023095-4dannjjm 5222 19 on on IN cord-023095-4dannjjm 5222 20 a a DT cord-023095-4dannjjm 5222 21 Visual visual JJ cord-023095-4dannjjm 5222 22 Analog analog NN cord-023095-4dannjjm 5222 23 Scale scale NN cord-023095-4dannjjm 5222 24 ( ( -LRB- cord-023095-4dannjjm 5222 25 VAS VAS NNP cord-023095-4dannjjm 5222 26 ) ) -RRB- cord-023095-4dannjjm 5222 27 that that WDT cord-023095-4dannjjm 5222 28 was be VBD cord-023095-4dannjjm 5222 29 converted convert VBN cord-023095-4dannjjm 5222 30 to to IN cord-023095-4dannjjm 5222 31 a a DT cord-023095-4dannjjm 5222 32 5-point 5-point CD cord-023095-4dannjjm 5222 33 scale scale NN cord-023095-4dannjjm 5222 34 . . . cord-023095-4dannjjm 5223 1 Twenty twenty CD cord-023095-4dannjjm 5223 2 - - HYPH cord-023095-4dannjjm 5223 3 six six CD cord-023095-4dannjjm 5223 4 IV IV NNP cord-023095-4dannjjm 5223 5 catheter catheter NN cord-023095-4dannjjm 5223 6 insertions insertion NNS cord-023095-4dannjjm 5223 7 in in IN cord-023095-4dannjjm 5223 8 normovolemic normovolemic JJ cord-023095-4dannjjm 5223 9 feline feline JJ cord-023095-4dannjjm 5223 10 and and CC cord-023095-4dannjjm 5223 11 canine canine JJ cord-023095-4dannjjm 5223 12 patients patient NNS cord-023095-4dannjjm 5223 13 performed perform VBN cord-023095-4dannjjm 5223 14 by by IN cord-023095-4dannjjm 5223 15 WCVM WCVM NNP cord-023095-4dannjjm 5223 16 Small Small NNP cord-023095-4dannjjm 5223 17 Animal Animal NNP cord-023095-4dannjjm 5223 18 Hospital Hospital NNP cord-023095-4dannjjm 5223 19 personnel personnel NNS cord-023095-4dannjjm 5223 20 ( ( -LRB- cord-023095-4dannjjm 5223 21 6 6 CD cord-023095-4dannjjm 5223 22 technicians technician NNS cord-023095-4dannjjm 5223 23 , , , cord-023095-4dannjjm 5223 24 16 16 CD cord-023095-4dannjjm 5223 25 veterinary veterinary JJ cord-023095-4dannjjm 5223 26 students student NNS cord-023095-4dannjjm 5223 27 , , , cord-023095-4dannjjm 5223 28 1 1 CD cord-023095-4dannjjm 5223 29 intern intern NN cord-023095-4dannjjm 5223 30 , , , cord-023095-4dannjjm 5223 31 1 1 CD cord-023095-4dannjjm 5223 32 resident resident NN cord-023095-4dannjjm 5223 33 , , , cord-023095-4dannjjm 5223 34 2 2 CD cord-023095-4dannjjm 5223 35 clinicians clinician NNS cord-023095-4dannjjm 5223 36 ) ) -RRB- cord-023095-4dannjjm 5223 37 were be VBD cord-023095-4dannjjm 5223 38 then then RB cord-023095-4dannjjm 5223 39 timed time VBN cord-023095-4dannjjm 5223 40 and and CC cord-023095-4dannjjm 5223 41 compared compare VBN cord-023095-4dannjjm 5223 42 to to IN cord-023095-4dannjjm 5223 43 the the DT cord-023095-4dannjjm 5223 44 mean mean JJ cord-023095-4dannjjm 5223 45 IO IO NNP cord-023095-4dannjjm 5223 46 catheter catheter NN cord-023095-4dannjjm 5223 47 insertion insertion NN cord-023095-4dannjjm 5223 48 time time NN cord-023095-4dannjjm 5223 49 in in IN cord-023095-4dannjjm 5223 50 feline feline JJ cord-023095-4dannjjm 5223 51 cadavers cadaver NNS cord-023095-4dannjjm 5223 52 by by IN cord-023095-4dannjjm 5223 53 study study NN cord-023095-4dannjjm 5223 54 participants participant NNS cord-023095-4dannjjm 5223 55 using use VBG cord-023095-4dannjjm 5223 56 the the DT cord-023095-4dannjjm 5223 57 EZ EZ NNP cord-023095-4dannjjm 5223 58 - - HYPH cord-023095-4dannjjm 5223 59 IO IO NNP cord-023095-4dannjjm 5223 60 G3 G3 NNP cord-023095-4dannjjm 5223 61 device device NN cord-023095-4dannjjm 5223 62 . . . cord-023095-4dannjjm 5224 1 The the DT cord-023095-4dannjjm 5224 2 IO IO NNP cord-023095-4dannjjm 5224 3 catheter catheter NN cord-023095-4dannjjm 5224 4 was be VBD cord-023095-4dannjjm 5224 5 inserted insert VBN cord-023095-4dannjjm 5224 6 correctly correctly RB cord-023095-4dannjjm 5224 7 on on IN cord-023095-4dannjjm 5224 8 every every DT cord-023095-4dannjjm 5224 9 attempt attempt NN cord-023095-4dannjjm 5224 10 by by IN cord-023095-4dannjjm 5224 11 70 70 CD cord-023095-4dannjjm 5224 12 % % NN cord-023095-4dannjjm 5224 13 ( ( -LRB- cord-023095-4dannjjm 5224 14 28/40 28/40 CD cord-023095-4dannjjm 5224 15 ) ) -RRB- cord-023095-4dannjjm 5224 16 of of IN cord-023095-4dannjjm 5224 17 participants participant NNS cord-023095-4dannjjm 5224 18 . . . cord-023095-4dannjjm 5225 1 No no DT cord-023095-4dannjjm 5225 2 difference difference NN cord-023095-4dannjjm 5225 3 was be VBD cord-023095-4dannjjm 5225 4 found find VBN cord-023095-4dannjjm 5225 5 between between IN cord-023095-4dannjjm 5225 6 participant participant NN cord-023095-4dannjjm 5225 7 groups group NNS cord-023095-4dannjjm 5225 8 for for IN cord-023095-4dannjjm 5225 9 mean mean JJ cord-023095-4dannjjm 5225 10 IO IO NNP cord-023095-4dannjjm 5225 11 catheter catheter NN cord-023095-4dannjjm 5225 12 placement placement NN cord-023095-4dannjjm 5225 13 confirmation confirmation NN cord-023095-4dannjjm 5225 14 percentage percentage NN cord-023095-4dannjjm 5226 1 ( ( -LRB- cord-023095-4dannjjm 5226 2 p p NN cord-023095-4dannjjm 5226 3 5 5 CD cord-023095-4dannjjm 5226 4 0.72 0.72 CD cord-023095-4dannjjm 5226 5 ) ) -RRB- cord-023095-4dannjjm 5226 6 . . . cord-023095-4dannjjm 5227 1 Percentage percentage NN cord-023095-4dannjjm 5227 2 of of IN cord-023095-4dannjjm 5227 3 IO IO NNP cord-023095-4dannjjm 5227 4 catheter catheter NN cord-023095-4dannjjm 5227 5 ' ' '' cord-023095-4dannjjm 5227 6 ' ' '' cord-023095-4dannjjm 5227 7 slippage slippage NN cord-023095-4dannjjm 5227 8 off off IN cord-023095-4dannjjm 5227 9 the the DT cord-023095-4dannjjm 5227 10 bone bone NN cord-023095-4dannjjm 5227 11 ' ' '' cord-023095-4dannjjm 5227 12 ' ' '' cord-023095-4dannjjm 5227 13 at at IN cord-023095-4dannjjm 5227 14 the the DT cord-023095-4dannjjm 5227 15 time time NN cord-023095-4dannjjm 5227 16 of of IN cord-023095-4dannjjm 5227 17 placement placement NN cord-023095-4dannjjm 5227 18 did do VBD cord-023095-4dannjjm 5227 19 not not RB cord-023095-4dannjjm 5227 20 vary vary VB cord-023095-4dannjjm 5227 21 across across IN cord-023095-4dannjjm 5227 22 participant participant NN cord-023095-4dannjjm 5227 23 groups group NNS cord-023095-4dannjjm 5228 1 ( ( -LRB- cord-023095-4dannjjm 5228 2 p p NN cord-023095-4dannjjm 5228 3 5 5 CD cord-023095-4dannjjm 5228 4 0.12 0.12 CD cord-023095-4dannjjm 5228 5 ) ) -RRB- cord-023095-4dannjjm 5228 6 . . . cord-023095-4dannjjm 5229 1 Mean mean JJ cord-023095-4dannjjm 5229 2 IO IO NNP cord-023095-4dannjjm 5229 3 catheter catheter NN cord-023095-4dannjjm 5229 4 insertion insertion NN cord-023095-4dannjjm 5229 5 times time NNS cord-023095-4dannjjm 5229 6 were be VBD cord-023095-4dannjjm 5229 7 all all RB cord-023095-4dannjjm 5229 8 less less JJR cord-023095-4dannjjm 5229 9 than than IN cord-023095-4dannjjm 5229 10 10 10 CD cord-023095-4dannjjm 5229 11 seconds second NNS cord-023095-4dannjjm 5229 12 and and CC cord-023095-4dannjjm 5229 13 did do VBD cord-023095-4dannjjm 5229 14 not not RB cord-023095-4dannjjm 5229 15 differ differ VB cord-023095-4dannjjm 5229 16 significantly significantly RB cord-023095-4dannjjm 5229 17 as as IN cord-023095-4dannjjm 5229 18 a a DT cord-023095-4dannjjm 5229 19 function function NN cord-023095-4dannjjm 5229 20 of of IN cord-023095-4dannjjm 5229 21 attempt attempt NN cord-023095-4dannjjm 5229 22 number number NN cord-023095-4dannjjm 5229 23 ( ( -LRB- cord-023095-4dannjjm 5229 24 p p NN cord-023095-4dannjjm 5229 25 5 5 CD cord-023095-4dannjjm 5229 26 0.93 0.93 CD cord-023095-4dannjjm 5229 27 ) ) -RRB- cord-023095-4dannjjm 5229 28 or or CC cord-023095-4dannjjm 5229 29 as as IN cord-023095-4dannjjm 5229 30 a a DT cord-023095-4dannjjm 5229 31 function function NN cord-023095-4dannjjm 5229 32 of of IN cord-023095-4dannjjm 5229 33 participant participant NN cord-023095-4dannjjm 5229 34 group group NN cord-023095-4dannjjm 5229 35 ( ( -LRB- cord-023095-4dannjjm 5229 36 p p NN cord-023095-4dannjjm 5229 37 5 5 CD cord-023095-4dannjjm 5229 38 0.78 0.78 CD cord-023095-4dannjjm 5229 39 ) ) -RRB- cord-023095-4dannjjm 5229 40 . . . cord-023095-4dannjjm 5230 1 Participants participant NNS cord-023095-4dannjjm 5230 2 rated rate VBD cord-023095-4dannjjm 5230 3 the the DT cord-023095-4dannjjm 5230 4 EZ EZ NNP cord-023095-4dannjjm 5230 5 - - HYPH cord-023095-4dannjjm 5230 6 IO IO NNP cord-023095-4dannjjm 5230 7 G3 G3 NNP cord-023095-4dannjjm 5230 8 's 's POS cord-023095-4dannjjm 5230 9 ' ' '' cord-023095-4dannjjm 5230 10 ' ' '' cord-023095-4dannjjm 5230 11 ease ease NN cord-023095-4dannjjm 5230 12 of of IN cord-023095-4dannjjm 5230 13 use use NN cord-023095-4dannjjm 5230 14 ' ' '' cord-023095-4dannjjm 5230 15 ' ' '' cord-023095-4dannjjm 5230 16 favorably favorably RB cord-023095-4dannjjm 5230 17 and and CC cord-023095-4dannjjm 5230 18 subjective subjective JJ cord-023095-4dannjjm 5230 19 scores score NNS cord-023095-4dannjjm 5230 20 did do VBD cord-023095-4dannjjm 5230 21 not not RB cord-023095-4dannjjm 5230 22 differ differ VB cord-023095-4dannjjm 5230 23 across across IN cord-023095-4dannjjm 5230 24 participant participant NN cord-023095-4dannjjm 5230 25 groups group NNS cord-023095-4dannjjm 5230 26 with with IN cord-023095-4dannjjm 5230 27 varying vary VBG cord-023095-4dannjjm 5230 28 levels level NNS cord-023095-4dannjjm 5230 29 of of IN cord-023095-4dannjjm 5230 30 clinical clinical JJ cord-023095-4dannjjm 5230 31 experience experience NN cord-023095-4dannjjm 5231 1 ( ( -LRB- cord-023095-4dannjjm 5231 2 p p NN cord-023095-4dannjjm 5231 3 4 4 CD cord-023095-4dannjjm 5231 4 0.2 0.2 CD cord-023095-4dannjjm 5231 5 ) ) -RRB- cord-023095-4dannjjm 5231 6 . . . cord-023095-4dannjjm 5232 1 Compared compare VBN cord-023095-4dannjjm 5232 2 to to IN cord-023095-4dannjjm 5232 3 the the DT cord-023095-4dannjjm 5232 4 mean mean JJ cord-023095-4dannjjm 5232 5 insertion insertion NN cord-023095-4dannjjm 5232 6 time time NN cord-023095-4dannjjm 5232 7 for for IN cord-023095-4dannjjm 5232 8 IV IV NNP cord-023095-4dannjjm 5232 9 catheterization catheterization NN cord-023095-4dannjjm 5232 10 ( ( -LRB- cord-023095-4dannjjm 5232 11 188 188 CD cord-023095-4dannjjm 5232 12 sec sec NNP cord-023095-4dannjjm 5232 13 ) ) -RRB- cord-023095-4dannjjm 5232 14 , , , cord-023095-4dannjjm 5232 15 mean mean JJ cord-023095-4dannjjm 5232 16 IO IO NNP cord-023095-4dannjjm 5232 17 catheter catheter NN cord-023095-4dannjjm 5232 18 insertion insertion NN cord-023095-4dannjjm 5232 19 by by IN cord-023095-4dannjjm 5232 20 participants participant NNS cord-023095-4dannjjm 5232 21 using use VBG cord-023095-4dannjjm 5232 22 the the DT cord-023095-4dannjjm 5232 23 EZ EZ NNP cord-023095-4dannjjm 5232 24 - - HYPH cord-023095-4dannjjm 5232 25 IO IO NNP cord-023095-4dannjjm 5232 26 G3 G3 NNP cord-023095-4dannjjm 5232 27 ( ( -LRB- cord-023095-4dannjjm 5232 28 8 8 CD cord-023095-4dannjjm 5232 29 sec sec NNP cord-023095-4dannjjm 5232 30 ) ) -RRB- cord-023095-4dannjjm 5232 31 was be VBD cord-023095-4dannjjm 5232 32 significantly significantly RB cord-023095-4dannjjm 5232 33 faster fast JJR cord-023095-4dannjjm 5233 1 ( ( -LRB- cord-023095-4dannjjm 5233 2 p p NN cord-023095-4dannjjm 5233 3 5 5 CD cord-023095-4dannjjm 5233 4 0.001 0.001 CD cord-023095-4dannjjm 5233 5 ) ) -RRB- cord-023095-4dannjjm 5233 6 . . . cord-023095-4dannjjm 5234 1 Regardless regardless RB cord-023095-4dannjjm 5234 2 of of IN cord-023095-4dannjjm 5234 3 their -PRON- PRP$ cord-023095-4dannjjm 5234 4 level level NN cord-023095-4dannjjm 5234 5 of of IN cord-023095-4dannjjm 5234 6 clinical clinical JJ cord-023095-4dannjjm 5234 7 experience experience NN cord-023095-4dannjjm 5234 8 , , , cord-023095-4dannjjm 5234 9 participants participant NNS cord-023095-4dannjjm 5234 10 rated rate VBD cord-023095-4dannjjm 5234 11 the the DT cord-023095-4dannjjm 5234 12 EZ EZ NNP cord-023095-4dannjjm 5234 13 - - HYPH cord-023095-4dannjjm 5234 14 IO IO NNP cord-023095-4dannjjm 5234 15 G3 G3 NNP cord-023095-4dannjjm 5234 16 device device NN cord-023095-4dannjjm 5234 17 favorably favorably RB cord-023095-4dannjjm 5234 18 in in IN cord-023095-4dannjjm 5234 19 terms term NNS cord-023095-4dannjjm 5234 20 of of IN cord-023095-4dannjjm 5234 21 its -PRON- PRP$ cord-023095-4dannjjm 5234 22 ' ' '' cord-023095-4dannjjm 5234 23 ' ' '' cord-023095-4dannjjm 5234 24 ease ease NN cord-023095-4dannjjm 5234 25 of of IN cord-023095-4dannjjm 5234 26 use use NN cord-023095-4dannjjm 5234 27 ' ' '' cord-023095-4dannjjm 5234 28 ' ' '' cord-023095-4dannjjm 5234 29 and and CC cord-023095-4dannjjm 5234 30 their -PRON- PRP$ cord-023095-4dannjjm 5234 31 willingness willingness NN cord-023095-4dannjjm 5234 32 to to TO cord-023095-4dannjjm 5234 33 use use VB cord-023095-4dannjjm 5234 34 the the DT cord-023095-4dannjjm 5234 35 device device NN cord-023095-4dannjjm 5234 36 in in IN cord-023095-4dannjjm 5234 37 the the DT cord-023095-4dannjjm 5234 38 future future NN cord-023095-4dannjjm 5234 39 . . . cord-023095-4dannjjm 5235 1 Regardless regardless RB cord-023095-4dannjjm 5235 2 of of IN cord-023095-4dannjjm 5235 3 their -PRON- PRP$ cord-023095-4dannjjm 5235 4 level level NN cord-023095-4dannjjm 5235 5 of of IN cord-023095-4dannjjm 5235 6 clinical clinical JJ cord-023095-4dannjjm 5235 7 experience experience NN cord-023095-4dannjjm 5235 8 , , , cord-023095-4dannjjm 5235 9 study study NN cord-023095-4dannjjm 5235 10 participants participant NNS cord-023095-4dannjjm 5235 11 successfully successfully RB cord-023095-4dannjjm 5235 12 placed place VBD cord-023095-4dannjjm 5235 13 IO IO NNP cord-023095-4dannjjm 5235 14 catheters catheter NNS cord-023095-4dannjjm 5235 15 using use VBG cord-023095-4dannjjm 5235 16 the the DT cord-023095-4dannjjm 5235 17 EZ EZ NNP cord-023095-4dannjjm 5235 18 - - HYPH cord-023095-4dannjjm 5235 19 IO IO NNP cord-023095-4dannjjm 5235 20 G3 G3 NNP cord-023095-4dannjjm 5235 21 device device NN cord-023095-4dannjjm 5235 22 and and CC cord-023095-4dannjjm 5235 23 did do VBD cord-023095-4dannjjm 5235 24 so so RB cord-023095-4dannjjm 5235 25 significantly significantly RB cord-023095-4dannjjm 5235 26 faster fast RBR cord-023095-4dannjjm 5235 27 than than IN cord-023095-4dannjjm 5235 28 the the DT cord-023095-4dannjjm 5235 29 reported report VBN cord-023095-4dannjjm 5235 30 IV IV NNP cord-023095-4dannjjm 5235 31 catheter catheter NN cord-023095-4dannjjm 5235 32 insertion insertion NN cord-023095-4dannjjm 5235 33 time time NN cord-023095-4dannjjm 5235 34 in in IN cord-023095-4dannjjm 5235 35 normovolemic normovolemic JJ cord-023095-4dannjjm 5235 36 feline feline JJ cord-023095-4dannjjm 5235 37 and and CC cord-023095-4dannjjm 5235 38 canine canine JJ cord-023095-4dannjjm 5235 39 patients patient NNS cord-023095-4dannjjm 5235 40 in in IN cord-023095-4dannjjm 5235 41 the the DT cord-023095-4dannjjm 5235 42 WCVM WCVM NNP cord-023095-4dannjjm 5235 43 Small Small NNP cord-023095-4dannjjm 5235 44 Animal Animal NNP cord-023095-4dannjjm 5235 45 Hospital Hospital NNP cord-023095-4dannjjm 5235 46 . . . cord-023095-4dannjjm 5236 1 Intraosseous intraosseous JJ cord-023095-4dannjjm 5236 2 catheterization catheterization NN cord-023095-4dannjjm 5236 3 using use VBG cord-023095-4dannjjm 5236 4 the the DT cord-023095-4dannjjm 5236 5 EZ EZ NNP cord-023095-4dannjjm 5236 6 - - HYPH cord-023095-4dannjjm 5236 7 IO IO NNP cord-023095-4dannjjm 5236 8 G3 G3 NNP cord-023095-4dannjjm 5236 9 has have VBZ cord-023095-4dannjjm 5236 10 the the DT cord-023095-4dannjjm 5236 11 potential potential NN cord-023095-4dannjjm 5236 12 to to TO cord-023095-4dannjjm 5236 13 provide provide VB cord-023095-4dannjjm 5236 14 very very RB cord-023095-4dannjjm 5236 15 rapid rapid JJ cord-023095-4dannjjm 5236 16 vascular vascular JJ cord-023095-4dannjjm 5236 17 access access NN cord-023095-4dannjjm 5236 18 and and CC cord-023095-4dannjjm 5236 19 is be VBZ cord-023095-4dannjjm 5236 20 a a DT cord-023095-4dannjjm 5236 21 skill skill NN cord-023095-4dannjjm 5236 22 that that WDT cord-023095-4dannjjm 5236 23 can can MD cord-023095-4dannjjm 5236 24 be be VB cord-023095-4dannjjm 5236 25 easily easily RB cord-023095-4dannjjm 5236 26 learned learn VBN cord-023095-4dannjjm 5236 27 . . . cord-023095-4dannjjm 5237 1 Previously previously RB cord-023095-4dannjjm 5237 2 presented present VBN cord-023095-4dannjjm 5237 3 at at IN cord-023095-4dannjjm 5237 4 the the DT cord-023095-4dannjjm 5237 5 Western Western NNP cord-023095-4dannjjm 5237 6 College College NNP cord-023095-4dannjjm 5237 7 of of IN cord-023095-4dannjjm 5237 8 Veterinary Veterinary NNP cord-023095-4dannjjm 5237 9 Medicine Medicine NNP cord-023095-4dannjjm 5237 10 Undergraduate Undergraduate NNP cord-023095-4dannjjm 5237 11 Poster Poster NNP cord-023095-4dannjjm 5237 12 Competition Competition NNP cord-023095-4dannjjm 5237 13 . . . cord-023095-4dannjjm 5238 1 Multicavitary multicavitary JJ cord-023095-4dannjjm 5238 2 effusion effusion NN cord-023095-4dannjjm 5238 3 is be VBZ cord-023095-4dannjjm 5238 4 a a DT cord-023095-4dannjjm 5238 5 common common JJ cord-023095-4dannjjm 5238 6 cause cause NN cord-023095-4dannjjm 5238 7 of of IN cord-023095-4dannjjm 5238 8 presentation presentation NN cord-023095-4dannjjm 5238 9 for for IN cord-023095-4dannjjm 5238 10 dogs dog NNS cord-023095-4dannjjm 5238 11 to to IN cord-023095-4dannjjm 5238 12 emergency emergency NN cord-023095-4dannjjm 5238 13 medical medical JJ cord-023095-4dannjjm 5238 14 centers center NNS cord-023095-4dannjjm 5238 15 . . . cord-023095-4dannjjm 5239 1 The the DT cord-023095-4dannjjm 5239 2 goal goal NN cord-023095-4dannjjm 5239 3 of of IN cord-023095-4dannjjm 5239 4 this this DT cord-023095-4dannjjm 5239 5 study study NN cord-023095-4dannjjm 5239 6 was be VBD cord-023095-4dannjjm 5239 7 to to TO cord-023095-4dannjjm 5239 8 identify identify VB cord-023095-4dannjjm 5239 9 common common JJ cord-023095-4dannjjm 5239 10 underlying underlying JJ cord-023095-4dannjjm 5239 11 causes cause NNS cord-023095-4dannjjm 5239 12 of of IN cord-023095-4dannjjm 5239 13 multicavitary multicavitary JJ cord-023095-4dannjjm 5239 14 effusion effusion NN cord-023095-4dannjjm 5239 15 as as RB cord-023095-4dannjjm 5239 16 well well RB cord-023095-4dannjjm 5239 17 as as IN cord-023095-4dannjjm 5239 18 determine determine VB cord-023095-4dannjjm 5239 19 their -PRON- PRP$ cord-023095-4dannjjm 5239 20 relative relative JJ cord-023095-4dannjjm 5239 21 importance importance NN cord-023095-4dannjjm 5239 22 . . . cord-023095-4dannjjm 5240 1 A a DT cord-023095-4dannjjm 5240 2 retrospective retrospective JJ cord-023095-4dannjjm 5240 3 analysis analysis NN cord-023095-4dannjjm 5240 4 of of IN cord-023095-4dannjjm 5240 5 43 43 CD cord-023095-4dannjjm 5240 6 cases case NNS cord-023095-4dannjjm 5240 7 of of IN cord-023095-4dannjjm 5240 8 multicavitary multicavitary JJ cord-023095-4dannjjm 5240 9 effusion effusion NN cord-023095-4dannjjm 5240 10 admitted admit VBD cord-023095-4dannjjm 5240 11 to to IN cord-023095-4dannjjm 5240 12 the the DT cord-023095-4dannjjm 5240 13 ICU ICU NNP cord-023095-4dannjjm 5240 14 of of IN cord-023095-4dannjjm 5240 15 a a DT cord-023095-4dannjjm 5240 16 tertiary tertiary JJ cord-023095-4dannjjm 5240 17 referral referral JJ cord-023095-4dannjjm 5240 18 center center NN cord-023095-4dannjjm 5240 19 ( ( -LRB- cord-023095-4dannjjm 5240 20 Ontario Ontario NNP cord-023095-4dannjjm 5240 21 Veterinary Veterinary NNP cord-023095-4dannjjm 5240 22 College College NNP cord-023095-4dannjjm 5240 23 ) ) -RRB- cord-023095-4dannjjm 5240 24 from from IN cord-023095-4dannjjm 5240 25 2007 2007 CD cord-023095-4dannjjm 5240 26 to to IN cord-023095-4dannjjm 5240 27 2010 2010 CD cord-023095-4dannjjm 5240 28 was be VBD cord-023095-4dannjjm 5240 29 performed perform VBN cord-023095-4dannjjm 5240 30 . . . cord-023095-4dannjjm 5241 1 Twenty twenty CD cord-023095-4dannjjm 5241 2 - - HYPH cord-023095-4dannjjm 5241 3 three three CD cord-023095-4dannjjm 5241 4 different different JJ cord-023095-4dannjjm 5241 5 breeds breed NNS cord-023095-4dannjjm 5241 6 , , , cord-023095-4dannjjm 5241 7 with with IN cord-023095-4dannjjm 5241 8 Golden Golden NNP cord-023095-4dannjjm 5241 9 and and CC cord-023095-4dannjjm 5241 10 Labrador Labrador NNP cord-023095-4dannjjm 5241 11 retrievers retriever NNS cord-023095-4dannjjm 5241 12 ( ( -LRB- cord-023095-4dannjjm 5241 13 25.6 25.6 CD cord-023095-4dannjjm 5241 14 % % NN cord-023095-4dannjjm 5241 15 and and CC cord-023095-4dannjjm 5241 16 14 14 CD cord-023095-4dannjjm 5241 17 % % NN cord-023095-4dannjjm 5241 18 , , , cord-023095-4dannjjm 5241 19 respectively respectively RB cord-023095-4dannjjm 5241 20 ) ) -RRB- cord-023095-4dannjjm 5241 21 being be VBG cord-023095-4dannjjm 5241 22 most most RBS cord-023095-4dannjjm 5241 23 commonly commonly RB cord-023095-4dannjjm 5241 24 seen see VBN cord-023095-4dannjjm 5241 25 , , , cord-023095-4dannjjm 5241 26 were be VBD cord-023095-4dannjjm 5241 27 included include VBN cord-023095-4dannjjm 5241 28 in in IN cord-023095-4dannjjm 5241 29 the the DT cord-023095-4dannjjm 5241 30 study study NN cord-023095-4dannjjm 5241 31 . . . cord-023095-4dannjjm 5242 1 Ages age NNS cord-023095-4dannjjm 5242 2 ranged range VBD cord-023095-4dannjjm 5242 3 from from IN cord-023095-4dannjjm 5242 4 2 2 CD cord-023095-4dannjjm 5242 5 to to TO cord-023095-4dannjjm 5242 6 14 14 CD cord-023095-4dannjjm 5242 7 years year NNS cord-023095-4dannjjm 5242 8 with with IN cord-023095-4dannjjm 5242 9 a a DT cord-023095-4dannjjm 5242 10 median median JJ cord-023095-4dannjjm 5242 11 age age NN cord-023095-4dannjjm 5242 12 of of IN cord-023095-4dannjjm 5242 13 9 9 CD cord-023095-4dannjjm 5242 14 years year NNS cord-023095-4dannjjm 5242 15 and and CC cord-023095-4dannjjm 5242 16 a a DT cord-023095-4dannjjm 5242 17 mean mean NN cord-023095-4dannjjm 5242 18 of of IN cord-023095-4dannjjm 5242 19 8.1 8.1 CD cord-023095-4dannjjm 5242 20 years year NNS cord-023095-4dannjjm 5242 21 . . . cord-023095-4dannjjm 5243 1 69.8 69.8 CD cord-023095-4dannjjm 5243 2 % % NN cord-023095-4dannjjm 5243 3 of of IN cord-023095-4dannjjm 5243 4 cases case NNS cord-023095-4dannjjm 5243 5 were be VBD cord-023095-4dannjjm 5243 6 males male NNS cord-023095-4dannjjm 5243 7 ( ( -LRB- cord-023095-4dannjjm 5243 8 30/43 30/43 CD cord-023095-4dannjjm 5243 9 cases case NNS cord-023095-4dannjjm 5243 10 ) ) -RRB- cord-023095-4dannjjm 5243 11 . . . cord-023095-4dannjjm 5244 1 Most most RBS cord-023095-4dannjjm 5244 2 common common JJ cord-023095-4dannjjm 5244 3 presenting present VBG cord-023095-4dannjjm 5244 4 signs sign NNS cord-023095-4dannjjm 5244 5 included include VBD cord-023095-4dannjjm 5244 6 lethargy lethargy NN cord-023095-4dannjjm 5244 7 ( ( -LRB- cord-023095-4dannjjm 5244 8 48.8 48.8 CD cord-023095-4dannjjm 5244 9 % % NN cord-023095-4dannjjm 5244 10 ) ) -RRB- cord-023095-4dannjjm 5244 11 , , , cord-023095-4dannjjm 5244 12 anorexia anorexia NN cord-023095-4dannjjm 5244 13 ( ( -LRB- cord-023095-4dannjjm 5244 14 32.6 32.6 CD cord-023095-4dannjjm 5244 15 % % NN cord-023095-4dannjjm 5244 16 ) ) -RRB- cord-023095-4dannjjm 5244 17 , , , cord-023095-4dannjjm 5244 18 vomiting vomit VBG cord-023095-4dannjjm 5244 19 ( ( -LRB- cord-023095-4dannjjm 5244 20 21 21 CD cord-023095-4dannjjm 5244 21 % % NN cord-023095-4dannjjm 5244 22 ) ) -RRB- cord-023095-4dannjjm 5244 23 and and CC cord-023095-4dannjjm 5244 24 dyspnea dyspnea NN cord-023095-4dannjjm 5244 25 ( ( -LRB- cord-023095-4dannjjm 5244 26 21 21 CD cord-023095-4dannjjm 5244 27 % % NN cord-023095-4dannjjm 5244 28 ) ) -RRB- cord-023095-4dannjjm 5244 29 . . . cord-023095-4dannjjm 5245 1 Cavitary cavitary JJ cord-023095-4dannjjm 5245 2 effusion effusion NN cord-023095-4dannjjm 5245 3 was be VBD cord-023095-4dannjjm 5245 4 detected detect VBN cord-023095-4dannjjm 5245 5 by by IN cord-023095-4dannjjm 5245 6 either either DT cord-023095-4dannjjm 5245 7 ultrasonography ultrasonography NN cord-023095-4dannjjm 5245 8 ( ( -LRB- cord-023095-4dannjjm 5245 9 pericardial pericardial JJ cord-023095-4dannjjm 5245 10 , , , cord-023095-4dannjjm 5245 11 pleural pleural JJ cord-023095-4dannjjm 5245 12 or or CC cord-023095-4dannjjm 5245 13 abdominal abdominal JJ cord-023095-4dannjjm 5245 14 ) ) -RRB- cord-023095-4dannjjm 5245 15 or or CC cord-023095-4dannjjm 5245 16 radiographs radiograph NNS cord-023095-4dannjjm 5245 17 ( ( -LRB- cord-023095-4dannjjm 5245 18 pleural pleural JJ cord-023095-4dannjjm 5245 19 ) ) -RRB- cord-023095-4dannjjm 5245 20 . . . cord-023095-4dannjjm 5246 1 Bicavitary bicavitary JJ cord-023095-4dannjjm 5246 2 effusion effusion NN cord-023095-4dannjjm 5246 3 was be VBD cord-023095-4dannjjm 5246 4 present present JJ cord-023095-4dannjjm 5246 5 in in IN cord-023095-4dannjjm 5246 6 28 28 CD cord-023095-4dannjjm 5246 7 cases case NNS cord-023095-4dannjjm 5246 8 ( ( -LRB- cord-023095-4dannjjm 5246 9 65.1 65.1 CD cord-023095-4dannjjm 5246 10 % % NN cord-023095-4dannjjm 5246 11 ) ) -RRB- cord-023095-4dannjjm 5246 12 whereas whereas IN cord-023095-4dannjjm 5246 13 15 15 CD cord-023095-4dannjjm 5246 14 cases case NNS cord-023095-4dannjjm 5246 15 ( ( -LRB- cord-023095-4dannjjm 5246 16 34.9 34.9 CD cord-023095-4dannjjm 5246 17 % % NN cord-023095-4dannjjm 5246 18 ) ) -RRB- cord-023095-4dannjjm 5246 19 had have VBD cord-023095-4dannjjm 5246 20 tricavitary tricavitary JJ cord-023095-4dannjjm 5246 21 effusion effusion NN cord-023095-4dannjjm 5246 22 . . . cord-023095-4dannjjm 5247 1 Neoplasia neoplasia NN cord-023095-4dannjjm 5247 2 was be VBD cord-023095-4dannjjm 5247 3 found find VBN cord-023095-4dannjjm 5247 4 to to TO cord-023095-4dannjjm 5247 5 be be VB cord-023095-4dannjjm 5247 6 the the DT cord-023095-4dannjjm 5247 7 most most RBS cord-023095-4dannjjm 5247 8 common common JJ cord-023095-4dannjjm 5247 9 underlying underlie VBG cord-023095-4dannjjm 5247 10 cause cause NN cord-023095-4dannjjm 5247 11 overall overall RB cord-023095-4dannjjm 5247 12 ( ( -LRB- cord-023095-4dannjjm 5247 13 51.2 51.2 CD cord-023095-4dannjjm 5247 14 % % NN cord-023095-4dannjjm 5247 15 ) ) -RRB- cord-023095-4dannjjm 5247 16 , , , cord-023095-4dannjjm 5247 17 with with IN cord-023095-4dannjjm 5247 18 hemangiosarcoma hemangiosarcoma NN cord-023095-4dannjjm 5247 19 being be VBG cord-023095-4dannjjm 5247 20 the the DT cord-023095-4dannjjm 5247 21 leading leading JJ cord-023095-4dannjjm 5247 22 type type NN cord-023095-4dannjjm 5247 23 ( ( -LRB- cord-023095-4dannjjm 5247 24 40.9 40.9 CD cord-023095-4dannjjm 5247 25 % % NN cord-023095-4dannjjm 5247 26 of of IN cord-023095-4dannjjm 5247 27 neoplasia neoplasia NN cord-023095-4dannjjm 5247 28 cases case NNS cord-023095-4dannjjm 5247 29 ) ) -RRB- cord-023095-4dannjjm 5247 30 , , , cord-023095-4dannjjm 5247 31 followed follow VBN cord-023095-4dannjjm 5247 32 by by IN cord-023095-4dannjjm 5247 33 congestive congestive JJ cord-023095-4dannjjm 5247 34 heart heart NN cord-023095-4dannjjm 5247 35 failure failure NN cord-023095-4dannjjm 5247 36 ( ( -LRB- cord-023095-4dannjjm 5247 37 9.3 9.3 CD cord-023095-4dannjjm 5247 38 % % NN cord-023095-4dannjjm 5247 39 ) ) -RRB- cord-023095-4dannjjm 5247 40 , , , cord-023095-4dannjjm 5247 41 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 5247 42 lymphangectasia lymphangectasia NNP cord-023095-4dannjjm 5247 43 ( ( -LRB- cord-023095-4dannjjm 5247 44 4.7 4.7 CD cord-023095-4dannjjm 5247 45 % % NN cord-023095-4dannjjm 5247 46 ) ) -RRB- cord-023095-4dannjjm 5247 47 , , , cord-023095-4dannjjm 5247 48 peritonitis peritonitis NN cord-023095-4dannjjm 5247 49 / / SYM cord-023095-4dannjjm 5247 50 pancreatitis pancreatitis NN cord-023095-4dannjjm 5247 51 ( ( -LRB- cord-023095-4dannjjm 5247 52 4.7 4.7 CD cord-023095-4dannjjm 5247 53 % % NN cord-023095-4dannjjm 5247 54 ) ) -RRB- cord-023095-4dannjjm 5247 55 , , , cord-023095-4dannjjm 5247 56 cirrhotic cirrhotic JJ cord-023095-4dannjjm 5247 57 liver liver NN cord-023095-4dannjjm 5247 58 disease disease NN cord-023095-4dannjjm 5247 59 ( ( -LRB- cord-023095-4dannjjm 5247 60 2.3 2.3 CD cord-023095-4dannjjm 5247 61 % % NN cord-023095-4dannjjm 5247 62 ) ) -RRB- cord-023095-4dannjjm 5247 63 and and CC cord-023095-4dannjjm 5247 64 acute acute JJ cord-023095-4dannjjm 5247 65 renal renal JJ cord-023095-4dannjjm 5247 66 failure failure NN cord-023095-4dannjjm 5247 67 ( ( -LRB- cord-023095-4dannjjm 5247 68 2.3 2.3 CD cord-023095-4dannjjm 5247 69 % % NN cord-023095-4dannjjm 5247 70 ) ) -RRB- cord-023095-4dannjjm 5247 71 . . . cord-023095-4dannjjm 5248 1 In in IN cord-023095-4dannjjm 5248 2 11 11 CD cord-023095-4dannjjm 5248 3 cases case NNS cord-023095-4dannjjm 5248 4 ( ( -LRB- cord-023095-4dannjjm 5248 5 25.6 25.6 CD cord-023095-4dannjjm 5248 6 % % NN cord-023095-4dannjjm 5248 7 ) ) -RRB- cord-023095-4dannjjm 5248 8 , , , cord-023095-4dannjjm 5248 9 no no DT cord-023095-4dannjjm 5248 10 underlying underlying JJ cord-023095-4dannjjm 5248 11 cause cause NN cord-023095-4dannjjm 5248 12 could could MD cord-023095-4dannjjm 5248 13 be be VB cord-023095-4dannjjm 5248 14 found find VBN cord-023095-4dannjjm 5248 15 . . . cord-023095-4dannjjm 5249 1 Of of IN cord-023095-4dannjjm 5249 2 these these DT cord-023095-4dannjjm 5249 3 , , , cord-023095-4dannjjm 5249 4 4 4 CD cord-023095-4dannjjm 5249 5 ( ( -LRB- cord-023095-4dannjjm 5249 6 9.3 9.3 CD cord-023095-4dannjjm 5249 7 % % NN cord-023095-4dannjjm 5249 8 of of IN cord-023095-4dannjjm 5249 9 all all DT cord-023095-4dannjjm 5249 10 cases case NNS cord-023095-4dannjjm 5249 11 ) ) -RRB- cord-023095-4dannjjm 5249 12 were be VBD cord-023095-4dannjjm 5249 13 diagnosed diagnose VBN cord-023095-4dannjjm 5249 14 as as IN cord-023095-4dannjjm 5249 15 having have VBG cord-023095-4dannjjm 5249 16 idiopathic idiopathic JJ cord-023095-4dannjjm 5249 17 pericardial pericardial JJ cord-023095-4dannjjm 5249 18 effusion effusion NN cord-023095-4dannjjm 5249 19 . . . cord-023095-4dannjjm 5250 1 Taken take VBN cord-023095-4dannjjm 5250 2 together together RB cord-023095-4dannjjm 5250 3 , , , cord-023095-4dannjjm 5250 4 these these DT cord-023095-4dannjjm 5250 5 findings finding NNS cord-023095-4dannjjm 5250 6 suggest suggest VBP cord-023095-4dannjjm 5250 7 a a DT cord-023095-4dannjjm 5250 8 strong strong JJ cord-023095-4dannjjm 5250 9 association association NN cord-023095-4dannjjm 5250 10 between between IN cord-023095-4dannjjm 5250 11 multicavitary multicavitary JJ cord-023095-4dannjjm 5250 12 effusion effusion NN cord-023095-4dannjjm 5250 13 and and CC cord-023095-4dannjjm 5250 14 diseases disease NNS cord-023095-4dannjjm 5250 15 carrying carry VBG cord-023095-4dannjjm 5250 16 a a DT cord-023095-4dannjjm 5250 17 guarded guard VBN cord-023095-4dannjjm 5250 18 prognosis prognosis NN cord-023095-4dannjjm 5250 19 in in IN cord-023095-4dannjjm 5250 20 dogs dog NNS cord-023095-4dannjjm 5250 21 . . . cord-023095-4dannjjm 5251 1 Infection infection NN cord-023095-4dannjjm 5251 2 control control NN cord-023095-4dannjjm 5251 3 practices practice NNS cord-023095-4dannjjm 5251 4 in in IN cord-023095-4dannjjm 5251 5 veterinary veterinary JJ cord-023095-4dannjjm 5251 6 clinics clinic NNS cord-023095-4dannjjm 5251 7 and and CC cord-023095-4dannjjm 5251 8 hospitals hospital NNS cord-023095-4dannjjm 5251 9 are be VBP cord-023095-4dannjjm 5251 10 becoming become VBG cord-023095-4dannjjm 5251 11 increasingly increasingly RB cord-023095-4dannjjm 5251 12 important important JJ cord-023095-4dannjjm 5251 13 , , , cord-023095-4dannjjm 5251 14 with with IN cord-023095-4dannjjm 5251 15 rising rise VBG cord-023095-4dannjjm 5251 16 client client NN cord-023095-4dannjjm 5251 17 expectations expectation NNS cord-023095-4dannjjm 5251 18 , , , cord-023095-4dannjjm 5251 19 growing grow VBG cord-023095-4dannjjm 5251 20 concern concern NN cord-023095-4dannjjm 5251 21 about about IN cord-023095-4dannjjm 5251 22 the the DT cord-023095-4dannjjm 5251 23 spread spread NN cord-023095-4dannjjm 5251 24 of of IN cord-023095-4dannjjm 5251 25 antimicrobial antimicrobial JJ cord-023095-4dannjjm 5251 26 - - HYPH cord-023095-4dannjjm 5251 27 resistant resistant JJ cord-023095-4dannjjm 5251 28 pathogens pathogen NNS cord-023095-4dannjjm 5251 29 , , , cord-023095-4dannjjm 5251 30 and and CC cord-023095-4dannjjm 5251 31 the the DT cord-023095-4dannjjm 5251 32 potential potential NN cord-023095-4dannjjm 5251 33 for for IN cord-023095-4dannjjm 5251 34 zoonotic zoonotic JJ cord-023095-4dannjjm 5251 35 transmission transmission NN cord-023095-4dannjjm 5251 36 of of IN cord-023095-4dannjjm 5251 37 disease disease NN cord-023095-4dannjjm 5251 38 . . . cord-023095-4dannjjm 5252 1 Surgical surgical JJ cord-023095-4dannjjm 5252 2 patients patient NNS cord-023095-4dannjjm 5252 3 are be VBP cord-023095-4dannjjm 5252 4 at at IN cord-023095-4dannjjm 5252 5 increased increase VBN cord-023095-4dannjjm 5252 6 risk risk NN cord-023095-4dannjjm 5252 7 of of IN cord-023095-4dannjjm 5252 8 developing develop VBG cord-023095-4dannjjm 5252 9 infections infection NNS cord-023095-4dannjjm 5252 10 , , , cord-023095-4dannjjm 5252 11 and and CC cord-023095-4dannjjm 5252 12 can can MD cord-023095-4dannjjm 5252 13 serve serve VB cord-023095-4dannjjm 5252 14 as as IN cord-023095-4dannjjm 5252 15 sources source NNS cord-023095-4dannjjm 5252 16 of of IN cord-023095-4dannjjm 5252 17 these these DT cord-023095-4dannjjm 5252 18 pathogens pathogen NNS cord-023095-4dannjjm 5252 19 for for IN cord-023095-4dannjjm 5252 20 other other JJ cord-023095-4dannjjm 5252 21 animals animal NNS cord-023095-4dannjjm 5252 22 and and CC cord-023095-4dannjjm 5252 23 people people NNS cord-023095-4dannjjm 5252 24 with with IN cord-023095-4dannjjm 5252 25 whom whom WP cord-023095-4dannjjm 5252 26 they -PRON- PRP cord-023095-4dannjjm 5252 27 have have VBP cord-023095-4dannjjm 5252 28 contact contact NN cord-023095-4dannjjm 5252 29 within within IN cord-023095-4dannjjm 5252 30 and and CC cord-023095-4dannjjm 5252 31 outside outside IN cord-023095-4dannjjm 5252 32 the the DT cord-023095-4dannjjm 5252 33 clinic clinic NN cord-023095-4dannjjm 5252 34 . . . cord-023095-4dannjjm 5253 1 Taking take VBG cord-023095-4dannjjm 5253 2 all all DT cord-023095-4dannjjm 5253 3 reasonable reasonable JJ cord-023095-4dannjjm 5253 4 precautions precaution NNS cord-023095-4dannjjm 5253 5 to to TO cord-023095-4dannjjm 5253 6 reduce reduce VB cord-023095-4dannjjm 5253 7 the the DT cord-023095-4dannjjm 5253 8 risk risk NN cord-023095-4dannjjm 5253 9 of of IN cord-023095-4dannjjm 5253 10 surgical surgical JJ cord-023095-4dannjjm 5253 11 site site NN cord-023095-4dannjjm 5253 12 infections infection NNS cord-023095-4dannjjm 5253 13 , , , cord-023095-4dannjjm 5253 14 beginning begin VBG cord-023095-4dannjjm 5253 15 with with IN cord-023095-4dannjjm 5253 16 preoperative preoperative JJ cord-023095-4dannjjm 5253 17 preparation preparation NN cord-023095-4dannjjm 5253 18 of of IN cord-023095-4dannjjm 5253 19 the the DT cord-023095-4dannjjm 5253 20 surgeon surgeon NN cord-023095-4dannjjm 5253 21 and and CC cord-023095-4dannjjm 5253 22 patient patient NN cord-023095-4dannjjm 5253 23 , , , cord-023095-4dannjjm 5253 24 is be VBZ cord-023095-4dannjjm 5253 25 therefore therefore RB cord-023095-4dannjjm 5253 26 an an DT cord-023095-4dannjjm 5253 27 important important JJ cord-023095-4dannjjm 5253 28 part part NN cord-023095-4dannjjm 5253 29 of of IN cord-023095-4dannjjm 5253 30 any any DT cord-023095-4dannjjm 5253 31 infection infection NN cord-023095-4dannjjm 5253 32 control control NN cord-023095-4dannjjm 5253 33 program program NN cord-023095-4dannjjm 5253 34 . . . cord-023095-4dannjjm 5254 1 While while IN cord-023095-4dannjjm 5254 2 guidelines guideline NNS cord-023095-4dannjjm 5254 3 are be VBP cord-023095-4dannjjm 5254 4 available available JJ cord-023095-4dannjjm 5254 5 for for IN cord-023095-4dannjjm 5254 6 preoperative preoperative JJ cord-023095-4dannjjm 5254 7 preparation preparation NN cord-023095-4dannjjm 5254 8 procedures procedure NNS cord-023095-4dannjjm 5254 9 , , , cord-023095-4dannjjm 5254 10 there there EX cord-023095-4dannjjm 5254 11 has have VBZ cord-023095-4dannjjm 5254 12 been be VBN cord-023095-4dannjjm 5254 13 no no DT cord-023095-4dannjjm 5254 14 objective objective JJ cord-023095-4dannjjm 5254 15 investigation investigation NN cord-023095-4dannjjm 5254 16 of of IN cord-023095-4dannjjm 5254 17 compliance compliance NN cord-023095-4dannjjm 5254 18 with with IN cord-023095-4dannjjm 5254 19 these these DT cord-023095-4dannjjm 5254 20 guidelines guideline NNS cord-023095-4dannjjm 5254 21 in in IN cord-023095-4dannjjm 5254 22 veterinary veterinary JJ cord-023095-4dannjjm 5254 23 practices practice NNS cord-023095-4dannjjm 5254 24 . . . cord-023095-4dannjjm 5255 1 The the DT cord-023095-4dannjjm 5255 2 objectives objective NNS cord-023095-4dannjjm 5255 3 of of IN cord-023095-4dannjjm 5255 4 this this DT cord-023095-4dannjjm 5255 5 pilot pilot NN cord-023095-4dannjjm 5255 6 study study NN cord-023095-4dannjjm 5255 7 were be VBD cord-023095-4dannjjm 5255 8 to to TO cord-023095-4dannjjm 5255 9 describe describe VB cord-023095-4dannjjm 5255 10 a a DT cord-023095-4dannjjm 5255 11 range range NN cord-023095-4dannjjm 5255 12 of of IN cord-023095-4dannjjm 5255 13 preoperative preoperative JJ cord-023095-4dannjjm 5255 14 hand hand NN cord-023095-4dannjjm 5255 15 scrub scrub NN cord-023095-4dannjjm 5255 16 and and CC cord-023095-4dannjjm 5255 17 surgical surgical JJ cord-023095-4dannjjm 5255 18 site site NN cord-023095-4dannjjm 5255 19 preparation preparation NN cord-023095-4dannjjm 5255 20 practices practice NNS cord-023095-4dannjjm 5255 21 in in IN cord-023095-4dannjjm 5255 22 veterinary veterinary JJ cord-023095-4dannjjm 5255 23 clinics clinic NNS cord-023095-4dannjjm 5255 24 , , , cord-023095-4dannjjm 5255 25 and and CC cord-023095-4dannjjm 5255 26 to to TO cord-023095-4dannjjm 5255 27 determine determine VB cord-023095-4dannjjm 5255 28 if if IN cord-023095-4dannjjm 5255 29 there there EX cord-023095-4dannjjm 5255 30 were be VBD cord-023095-4dannjjm 5255 31 any any DT cord-023095-4dannjjm 5255 32 areas area NNS cord-023095-4dannjjm 5255 33 that that WDT cord-023095-4dannjjm 5255 34 consistently consistently RB cord-023095-4dannjjm 5255 35 require require VBP cord-023095-4dannjjm 5255 36 improvement improvement NN cord-023095-4dannjjm 5255 37 . . . cord-023095-4dannjjm 5256 1 Observation observation NN cord-023095-4dannjjm 5256 2 of of IN cord-023095-4dannjjm 5256 3 preparation preparation NN cord-023095-4dannjjm 5256 4 practices practice NNS cord-023095-4dannjjm 5256 5 was be VBD cord-023095-4dannjjm 5256 6 performed perform VBN cord-023095-4dannjjm 5256 7 in in IN cord-023095-4dannjjm 5256 8 each each DT cord-023095-4dannjjm 5256 9 of of IN cord-023095-4dannjjm 5256 10 ten ten CD cord-023095-4dannjjm 5256 11 clinics clinic NNS cord-023095-4dannjjm 5256 12 over over IN cord-023095-4dannjjm 5256 13 9 9 CD cord-023095-4dannjjm 5256 14 - - SYM cord-023095-4dannjjm 5256 15 14 14 CD cord-023095-4dannjjm 5256 16 days day NNS cord-023095-4dannjjm 5256 17 using use VBG cord-023095-4dannjjm 5256 18 2 2 CD cord-023095-4dannjjm 5256 19 - - SYM cord-023095-4dannjjm 5256 20 3 3 CD cord-023095-4dannjjm 5256 21 small small JJ cord-023095-4dannjjm 5256 22 wireless wireless NN cord-023095-4dannjjm 5256 23 surveillance surveillance NN cord-023095-4dannjjm 5256 24 cameras camera NNS cord-023095-4dannjjm 5256 25 . . . cord-023095-4dannjjm 5257 1 Data datum NNS cord-023095-4dannjjm 5257 2 was be VBD cord-023095-4dannjjm 5257 3 coded code VBN cord-023095-4dannjjm 5257 4 for for IN cord-023095-4dannjjm 5257 5 148 148 CD cord-023095-4dannjjm 5257 6 surgical surgical JJ cord-023095-4dannjjm 5257 7 patients patient NNS cord-023095-4dannjjm 5257 8 , , , cord-023095-4dannjjm 5257 9 and and CC cord-023095-4dannjjm 5257 10 31 31 CD cord-023095-4dannjjm 5257 11 surgeons surgeon NNS cord-023095-4dannjjm 5257 12 performing perform VBG cord-023095-4dannjjm 5257 13 a a DT cord-023095-4dannjjm 5257 14 total total NN cord-023095-4dannjjm 5257 15 of of IN cord-023095-4dannjjm 5257 16 190 190 CD cord-023095-4dannjjm 5257 17 hand hand NN cord-023095-4dannjjm 5257 18 scrubs scrub NNS cord-023095-4dannjjm 5257 19 . . . cord-023095-4dannjjm 5258 1 Patient patient JJ cord-023095-4dannjjm 5258 2 hair hair NN cord-023095-4dannjjm 5258 3 removal removal NN cord-023095-4dannjjm 5258 4 was be VBD cord-023095-4dannjjm 5258 5 most most RBS cord-023095-4dannjjm 5258 6 commonly commonly RB cord-023095-4dannjjm 5258 7 performed perform VBN cord-023095-4dannjjm 5258 8 after after IN cord-023095-4dannjjm 5258 9 induction induction NN cord-023095-4dannjjm 5258 10 of of IN cord-023095-4dannjjm 5258 11 the the DT cord-023095-4dannjjm 5258 12 animal animal NN cord-023095-4dannjjm 5258 13 ( ( -LRB- cord-023095-4dannjjm 5258 14 129/140 129/140 CD cord-023095-4dannjjm 5258 15 , , , cord-023095-4dannjjm 5258 16 92 92 CD cord-023095-4dannjjm 5258 17 % % NN cord-023095-4dannjjm 5258 18 ) ) -RRB- cord-023095-4dannjjm 5258 19 and and CC cord-023095-4dannjjm 5258 20 using use VBG cord-023095-4dannjjm 5258 21 clippers clipper NNS cord-023095-4dannjjm 5258 22 ( ( -LRB- cord-023095-4dannjjm 5258 23 114/137 114/137 CD cord-023095-4dannjjm 5258 24 , , , cord-023095-4dannjjm 5258 25 83 83 CD cord-023095-4dannjjm 5258 26 % % NN cord-023095-4dannjjm 5258 27 ) ) -RRB- cord-023095-4dannjjm 5258 28 . . . cord-023095-4dannjjm 5259 1 Steps step NNS cord-023095-4dannjjm 5259 2 in in IN cord-023095-4dannjjm 5259 3 surgical surgical JJ cord-023095-4dannjjm 5259 4 site site NN cord-023095-4dannjjm 5259 5 aseptic aseptic JJ cord-023095-4dannjjm 5259 6 preparation preparation NN cord-023095-4dannjjm 5259 7 ranged range VBD cord-023095-4dannjjm 5259 8 from from IN cord-023095-4dannjjm 5259 9 1 1 CD cord-023095-4dannjjm 5259 10 - - SYM cord-023095-4dannjjm 5259 11 4 4 CD cord-023095-4dannjjm 5259 12 . . . cord-023095-4dannjjm 5260 1 Contact contact NN cord-023095-4dannjjm 5260 2 time time NN cord-023095-4dannjjm 5260 3 with with IN cord-023095-4dannjjm 5260 4 soap soap NN cord-023095-4dannjjm 5260 5 ranged range VBD cord-023095-4dannjjm 5260 6 from from IN cord-023095-4dannjjm 5260 7 18 18 CD cord-023095-4dannjjm 5260 8 - - SYM cord-023095-4dannjjm 5260 9 369s 369s CD cord-023095-4dannjjm 5260 10 ( ( -LRB- cord-023095-4dannjjm 5260 11 mean mean UH cord-023095-4dannjjm 5260 12 82s 82 NNS cord-023095-4dannjjm 5260 13 , , , cord-023095-4dannjjm 5260 14 median median JJ cord-023095-4dannjjm 5260 15 53s 53s NNPS cord-023095-4dannjjm 5260 16 ) ) -RRB- cord-023095-4dannjjm 5260 17 , , , cord-023095-4dannjjm 5260 18 and and CC cord-023095-4dannjjm 5260 19 with with IN cord-023095-4dannjjm 5260 20 alcohol alcohol NN cord-023095-4dannjjm 5260 21 from from IN cord-023095-4dannjjm 5260 22 3 3 CD cord-023095-4dannjjm 5260 23 - - HYPH cord-023095-4dannjjm 5260 24 220s 220s NNPS cord-023095-4dannjjm 5260 25 ( ( -LRB- cord-023095-4dannjjm 5260 26 mean mean UH cord-023095-4dannjjm 5260 27 41s 41s CD cord-023095-4dannjjm 5260 28 , , , cord-023095-4dannjjm 5260 29 median median JJ cord-023095-4dannjjm 5260 30 30.5s 30.5s NNP cord-023095-4dannjjm 5260 31 ) ) -RRB- cord-023095-4dannjjm 5260 32 . . . cord-023095-4dannjjm 5261 1 Application application NN cord-023095-4dannjjm 5261 2 of of IN cord-023095-4dannjjm 5261 3 alcohol alcohol NN cord-023095-4dannjjm 5261 4 or or CC cord-023095-4dannjjm 5261 5 antiseptic antiseptic JJ cord-023095-4dannjjm 5261 6 using use VBG cord-023095-4dannjjm 5261 7 a a DT cord-023095-4dannjjm 5261 8 ' ' '' cord-023095-4dannjjm 5261 9 ' ' '' cord-023095-4dannjjm 5261 10 cleanest clean JJS cord-023095-4dannjjm 5261 11 to to IN cord-023095-4dannjjm 5261 12 dirtiest dirty JJS cord-023095-4dannjjm 5261 13 ' ' '' cord-023095-4dannjjm 5261 14 ' ' '' cord-023095-4dannjjm 5261 15 pattern pattern NN cord-023095-4dannjjm 5261 16 was be VBD cord-023095-4dannjjm 5261 17 infrequent infrequent JJ cord-023095-4dannjjm 5261 18 ( ( -LRB- cord-023095-4dannjjm 5261 19 29/66 29/66 CD cord-023095-4dannjjm 5261 20 ( ( -LRB- cord-023095-4dannjjm 5261 21 44 44 CD cord-023095-4dannjjm 5261 22 % % NN cord-023095-4dannjjm 5261 23 ) ) -RRB- cord-023095-4dannjjm 5261 24 and and CC cord-023095-4dannjjm 5261 25 11/83 11/83 CD cord-023095-4dannjjm 5261 26 ( ( -LRB- cord-023095-4dannjjm 5261 27 13 13 CD cord-023095-4dannjjm 5261 28 % % NN cord-023095-4dannjjm 5261 29 ) ) -RRB- cord-023095-4dannjjm 5261 30 , , , cord-023095-4dannjjm 5261 31 respectively respectively RB cord-023095-4dannjjm 5261 32 ) ) -RRB- cord-023095-4dannjjm 5261 33 . . . cord-023095-4dannjjm 5262 1 Potential potential JJ cord-023095-4dannjjm 5262 2 contamination contamination NN cord-023095-4dannjjm 5262 3 of of IN cord-023095-4dannjjm 5262 4 the the DT cord-023095-4dannjjm 5262 5 surgical surgical JJ cord-023095-4dannjjm 5262 6 site site NN cord-023095-4dannjjm 5262 7 occurred occur VBD cord-023095-4dannjjm 5262 8 most most RBS cord-023095-4dannjjm 5262 9 frequently frequently RB cord-023095-4dannjjm 5262 10 when when WRB cord-023095-4dannjjm 5262 11 the the DT cord-023095-4dannjjm 5262 12 animal animal NN cord-023095-4dannjjm 5262 13 was be VBD cord-023095-4dannjjm 5262 14 moved move VBN cord-023095-4dannjjm 5262 15 to to IN cord-023095-4dannjjm 5262 16 the the DT cord-023095-4dannjjm 5262 17 surgery surgery NN cord-023095-4dannjjm 5262 18 table table NN cord-023095-4dannjjm 5262 19 after after IN cord-023095-4dannjjm 5262 20 initial initial JJ cord-023095-4dannjjm 5262 21 preparation preparation NN cord-023095-4dannjjm 5262 22 ( ( -LRB- cord-023095-4dannjjm 5262 23 40/58 40/58 CD cord-023095-4dannjjm 5262 24 , , , cord-023095-4dannjjm 5262 25 69 69 CD cord-023095-4dannjjm 5262 26 % % NN cord-023095-4dannjjm 5262 27 ) ) -RRB- cord-023095-4dannjjm 5262 28 . . . cord-023095-4dannjjm 5263 1 Preoperative Preoperative NNP cord-023095-4dannjjm 5263 2 alcohol alcohol NN cord-023095-4dannjjm 5263 3 hand hand NN cord-023095-4dannjjm 5263 4 rub rub NN cord-023095-4dannjjm 5263 5 was be VBD cord-023095-4dannjjm 5263 6 used use VBN cord-023095-4dannjjm 5263 7 in in IN cord-023095-4dannjjm 5263 8 2/10 2/10 CD cord-023095-4dannjjm 5263 9 facilities facility NNS cord-023095-4dannjjm 5263 10 , , , cord-023095-4dannjjm 5263 11 but but CC cord-023095-4dannjjm 5263 12 soap soap NN cord-023095-4dannjjm 5263 13 and and CC cord-023095-4dannjjm 5263 14 water water NN cord-023095-4dannjjm 5263 15 hand hand NN cord-023095-4dannjjm 5263 16 scrub scrub NN cord-023095-4dannjjm 5263 17 was be VBD cord-023095-4dannjjm 5263 18 still still RB cord-023095-4dannjjm 5263 19 more more RBR cord-023095-4dannjjm 5263 20 commonly commonly RB cord-023095-4dannjjm 5263 21 used use VBN cord-023095-4dannjjm 5263 22 even even RB cord-023095-4dannjjm 5263 23 at at IN cord-023095-4dannjjm 5263 24 these these DT cord-023095-4dannjjm 5263 25 clinics clinic NNS cord-023095-4dannjjm 5263 26 . . . cord-023095-4dannjjm 5264 1 Proximal Proximal NNP cord-023095-4dannjjm 5264 2 - - HYPH cord-023095-4dannjjm 5264 3 to to IN cord-023095-4dannjjm 5264 4 - - HYPH cord-023095-4dannjjm 5264 5 distal distal JJ cord-023095-4dannjjm 5264 6 scrubbing scrubbing NN cord-023095-4dannjjm 5264 7 was be VBD cord-023095-4dannjjm 5264 8 noted note VBN cord-023095-4dannjjm 5264 9 in in IN cord-023095-4dannjjm 5264 10 95/142 95/142 CD cord-023095-4dannjjm 5264 11 ( ( -LRB- cord-023095-4dannjjm 5264 12 67 67 CD cord-023095-4dannjjm 5264 13 % % NN cord-023095-4dannjjm 5264 14 ) ) -RRB- cord-023095-4dannjjm 5264 15 of of IN cord-023095-4dannjjm 5264 16 soap soap NN cord-023095-4dannjjm 5264 17 and and CC cord-023095-4dannjjm 5264 18 water water NN cord-023095-4dannjjm 5264 19 scrubs scrub NNS cord-023095-4dannjjm 5264 20 . . . cord-023095-4dannjjm 5265 1 Contact contact NN cord-023095-4dannjjm 5265 2 time time NN cord-023095-4dannjjm 5265 3 during during IN cord-023095-4dannjjm 5265 4 surgeon surgeon NN cord-023095-4dannjjm 5265 5 hand hand NN cord-023095-4dannjjm 5265 6 preparation preparation NN cord-023095-4dannjjm 5265 7 ranged range VBD cord-023095-4dannjjm 5265 8 from from IN cord-023095-4dannjjm 5265 9 7 7 CD cord-023095-4dannjjm 5265 10 - - HYPH cord-023095-4dannjjm 5265 11 529s 529 NNS cord-023095-4dannjjm 5265 12 ( ( -LRB- cord-023095-4dannjjm 5265 13 mean mean VBP cord-023095-4dannjjm 5265 14 144s 144s CD cord-023095-4dannjjm 5265 15 , , , cord-023095-4dannjjm 5265 16 median median JJ cord-023095-4dannjjm 5265 17 124s 124s CD cord-023095-4dannjjm 5265 18 ) ) -RRB- cord-023095-4dannjjm 5265 19 for for IN cord-023095-4dannjjm 5265 20 soap soap NN cord-023095-4dannjjm 5265 21 and and CC cord-023095-4dannjjm 5265 22 water water NN cord-023095-4dannjjm 5265 23 and and CC cord-023095-4dannjjm 5265 24 from from IN cord-023095-4dannjjm 5265 25 4 4 CD cord-023095-4dannjjm 5265 26 - - HYPH cord-023095-4dannjjm 5265 27 123s 123 NNS cord-023095-4dannjjm 5265 28 ( ( -LRB- cord-023095-4dannjjm 5265 29 mean mean UH cord-023095-4dannjjm 5265 30 34s 34 NNS cord-023095-4dannjjm 5265 31 , , , cord-023095-4dannjjm 5265 32 median median JJ cord-023095-4dannjjm 5265 33 25s 25 NNS cord-023095-4dannjjm 5265 34 ) ) -RRB- cord-023095-4dannjjm 5265 35 for for IN cord-023095-4dannjjm 5265 36 alcohol alcohol NN cord-023095-4dannjjm 5265 37 - - HYPH cord-023095-4dannjjm 5265 38 based base VBN cord-023095-4dannjjm 5265 39 hand hand NN cord-023095-4dannjjm 5265 40 rub rub NN cord-023095-4dannjjm 5265 41 . . . cord-023095-4dannjjm 5266 1 Approximately approximately RB cord-023095-4dannjjm 5266 2 75 75 CD cord-023095-4dannjjm 5266 3 % % NN cord-023095-4dannjjm 5266 4 of of IN cord-023095-4dannjjm 5266 5 the the DT cord-023095-4dannjjm 5266 6 variation variation NN cord-023095-4dannjjm 5266 7 in in IN cord-023095-4dannjjm 5266 8 contact contact NN cord-023095-4dannjjm 5266 9 time time NN cord-023095-4dannjjm 5266 10 was be VBD cord-023095-4dannjjm 5266 11 due due JJ cord-023095-4dannjjm 5266 12 to to IN cord-023095-4dannjjm 5266 13 inter inter JJ cord-023095-4dannjjm 5266 14 - - JJ cord-023095-4dannjjm 5266 15 surgeon surgeon NN cord-023095-4dannjjm 5266 16 variation variation NN cord-023095-4dannjjm 5266 17 . . . cord-023095-4dannjjm 5267 1 No no DT cord-023095-4dannjjm 5267 2 significant significant JJ cord-023095-4dannjjm 5267 3 changes change NNS cord-023095-4dannjjm 5267 4 in in IN cord-023095-4dannjjm 5267 5 practices practice NNS cord-023095-4dannjjm 5267 6 were be VBD cord-023095-4dannjjm 5267 7 identified identify VBN cord-023095-4dannjjm 5267 8 over over IN cord-023095-4dannjjm 5267 9 the the DT cord-023095-4dannjjm 5267 10 course course NN cord-023095-4dannjjm 5267 11 of of IN cord-023095-4dannjjm 5267 12 the the DT cord-023095-4dannjjm 5267 13 observation observation NN cord-023095-4dannjjm 5267 14 period period NN cord-023095-4dannjjm 5267 15 . . . cord-023095-4dannjjm 5268 1 Some some DT cord-023095-4dannjjm 5268 2 preoperative preoperative JJ cord-023095-4dannjjm 5268 3 preparation preparation NN cord-023095-4dannjjm 5268 4 practices practice NNS cord-023095-4dannjjm 5268 5 were be VBD cord-023095-4dannjjm 5268 6 fairly fairly RB cord-023095-4dannjjm 5268 7 consistent consistent JJ cord-023095-4dannjjm 5268 8 between between IN cord-023095-4dannjjm 5268 9 clinics clinic NNS cord-023095-4dannjjm 5268 10 in in IN cord-023095-4dannjjm 5268 11 this this DT cord-023095-4dannjjm 5268 12 study study NN cord-023095-4dannjjm 5268 13 , , , cord-023095-4dannjjm 5268 14 while while IN cord-023095-4dannjjm 5268 15 others other NNS cord-023095-4dannjjm 5268 16 varied vary VBD cord-023095-4dannjjm 5268 17 considerably considerably RB cord-023095-4dannjjm 5268 18 . . . cord-023095-4dannjjm 5269 1 Contact contact NN cord-023095-4dannjjm 5269 2 times time NNS cord-023095-4dannjjm 5269 3 with with IN cord-023095-4dannjjm 5269 4 preparatory preparatory JJ cord-023095-4dannjjm 5269 5 solutions solution NNS cord-023095-4dannjjm 5269 6 were be VBD cord-023095-4dannjjm 5269 7 often often RB cord-023095-4dannjjm 5269 8 far far RB cord-023095-4dannjjm 5269 9 shorter short JJR cord-023095-4dannjjm 5269 10 than than IN cord-023095-4dannjjm 5269 11 recommended recommend VBN cord-023095-4dannjjm 5269 12 , , , cord-023095-4dannjjm 5269 13 and and CC cord-023095-4dannjjm 5269 14 there there EX cord-023095-4dannjjm 5269 15 was be VBD cord-023095-4dannjjm 5269 16 a a DT cord-023095-4dannjjm 5269 17 high high JJ cord-023095-4dannjjm 5269 18 frequency frequency NN cord-023095-4dannjjm 5269 19 of of IN cord-023095-4dannjjm 5269 20 non non JJ cord-023095-4dannjjm 5269 21 - - JJ cord-023095-4dannjjm 5269 22 sterile sterile JJ cord-023095-4dannjjm 5269 23 contact contact NN cord-023095-4dannjjm 5269 24 with with IN cord-023095-4dannjjm 5269 25 the the DT cord-023095-4dannjjm 5269 26 surgical surgical JJ cord-023095-4dannjjm 5269 27 site site NN cord-023095-4dannjjm 5269 28 during during IN cord-023095-4dannjjm 5269 29 movement movement NN cord-023095-4dannjjm 5269 30 of of IN cord-023095-4dannjjm 5269 31 patients patient NNS cord-023095-4dannjjm 5269 32 to to IN cord-023095-4dannjjm 5269 33 the the DT cord-023095-4dannjjm 5269 34 surgical surgical JJ cord-023095-4dannjjm 5269 35 suite suite NN cord-023095-4dannjjm 5269 36 . . . cord-023095-4dannjjm 5270 1 The the DT cord-023095-4dannjjm 5270 2 camera camera NN cord-023095-4dannjjm 5270 3 system system NN cord-023095-4dannjjm 5270 4 used use VBD cord-023095-4dannjjm 5270 5 to to TO cord-023095-4dannjjm 5270 6 perform perform VB cord-023095-4dannjjm 5270 7 this this DT cord-023095-4dannjjm 5270 8 study study NN cord-023095-4dannjjm 5270 9 did do VBD cord-023095-4dannjjm 5270 10 not not RB cord-023095-4dannjjm 5270 11 have have VB cord-023095-4dannjjm 5270 12 a a DT cord-023095-4dannjjm 5270 13 significant significant JJ cord-023095-4dannjjm 5270 14 time time NN cord-023095-4dannjjm 5270 15 - - HYPH cord-023095-4dannjjm 5270 16 dependent dependent JJ cord-023095-4dannjjm 5270 17 effect effect NN cord-023095-4dannjjm 5270 18 on on IN cord-023095-4dannjjm 5270 19 the the DT cord-023095-4dannjjm 5270 20 behavior behavior NN cord-023095-4dannjjm 5270 21 of of IN cord-023095-4dannjjm 5270 22 participants participant NNS cord-023095-4dannjjm 5270 23 , , , cord-023095-4dannjjm 5270 24 and and CC cord-023095-4dannjjm 5270 25 could could MD cord-023095-4dannjjm 5270 26 be be VB cord-023095-4dannjjm 5270 27 useful useful JJ cord-023095-4dannjjm 5270 28 for for IN cord-023095-4dannjjm 5270 29 performing perform VBG cord-023095-4dannjjm 5270 30 similar similar JJ cord-023095-4dannjjm 5270 31 field field NN cord-023095-4dannjjm 5270 32 - - HYPH cord-023095-4dannjjm 5270 33 based base VBN cord-023095-4dannjjm 5270 34 observational observational JJ cord-023095-4dannjjm 5270 35 studies study NNS cord-023095-4dannjjm 5270 36 in in IN cord-023095-4dannjjm 5270 37 the the DT cord-023095-4dannjjm 5270 38 future future NN cord-023095-4dannjjm 5270 39 . . . cord-023095-4dannjjm 5271 1 This this DT cord-023095-4dannjjm 5271 2 prospective prospective JJ cord-023095-4dannjjm 5271 3 randomized randomized JJ cord-023095-4dannjjm 5271 4 study study NN cord-023095-4dannjjm 5271 5 compared compare VBD cord-023095-4dannjjm 5271 6 the the DT cord-023095-4dannjjm 5271 7 percentage percentage NN cord-023095-4dannjjm 5271 8 of of IN cord-023095-4dannjjm 5271 9 successful successful JJ cord-023095-4dannjjm 5271 10 intraosseous intraosseous JJ cord-023095-4dannjjm 5271 11 ( ( -LRB- cord-023095-4dannjjm 5271 12 IO IO NNP cord-023095-4dannjjm 5271 13 ) ) -RRB- cord-023095-4dannjjm 5271 14 catheter catheter NN cord-023095-4dannjjm 5271 15 insertions insertion NNS cord-023095-4dannjjm 5271 16 , , , cord-023095-4dannjjm 5271 17 insertion insertion NN cord-023095-4dannjjm 5271 18 times time NNS cord-023095-4dannjjm 5271 19 , , , cord-023095-4dannjjm 5271 20 and and CC cord-023095-4dannjjm 5271 21 ' ' '' cord-023095-4dannjjm 5271 22 ' ' '' cord-023095-4dannjjm 5271 23 ease ease NN cord-023095-4dannjjm 5271 24 of of IN cord-023095-4dannjjm 5271 25 use use NN cord-023095-4dannjjm 5271 26 ' ' '' cord-023095-4dannjjm 5271 27 ' ' '' cord-023095-4dannjjm 5271 28 scores score NNS cord-023095-4dannjjm 5271 29 using use VBG cord-023095-4dannjjm 5271 30 the the DT cord-023095-4dannjjm 5271 31 EZ EZ NNP cord-023095-4dannjjm 5271 32 - - HYPH cord-023095-4dannjjm 5271 33 IO IO NNP cord-023095-4dannjjm 5271 34 G3 G3 NNP cord-023095-4dannjjm 5271 35 power power NN cord-023095-4dannjjm 5271 36 driver driver NN cord-023095-4dannjjm 5271 37 to to IN cord-023095-4dannjjm 5271 38 manual manual JJ cord-023095-4dannjjm 5271 39 IO IO NNP cord-023095-4dannjjm 5271 40 catheterization catheterization NN cord-023095-4dannjjm 5271 41 in in IN cord-023095-4dannjjm 5271 42 feline feline JJ cord-023095-4dannjjm 5271 43 cadavers cadaver NNS cord-023095-4dannjjm 5271 44 . . . cord-023095-4dannjjm 5272 1 The the DT cord-023095-4dannjjm 5272 2 IO IO NNP cord-023095-4dannjjm 5272 3 catheter catheter NN cord-023095-4dannjjm 5272 4 insertion insertion NN cord-023095-4dannjjm 5272 5 time time NN cord-023095-4dannjjm 5272 6 in in IN cord-023095-4dannjjm 5272 7 cadavers cadaver NNS cord-023095-4dannjjm 5272 8 using use VBG cord-023095-4dannjjm 5272 9 the the DT cord-023095-4dannjjm 5272 10 EZ EZ NNP cord-023095-4dannjjm 5272 11 - - HYPH cord-023095-4dannjjm 5272 12 IO IO NNP cord-023095-4dannjjm 5272 13 G3 G3 NNP cord-023095-4dannjjm 5272 14 device device NN cord-023095-4dannjjm 5272 15 was be VBD cord-023095-4dannjjm 5272 16 also also RB cord-023095-4dannjjm 5272 17 compared compare VBN cord-023095-4dannjjm 5272 18 to to IN cord-023095-4dannjjm 5272 19 IV IV NNP cord-023095-4dannjjm 5272 20 catheter catheter NN cord-023095-4dannjjm 5272 21 insertion insertion NN cord-023095-4dannjjm 5272 22 time time NN cord-023095-4dannjjm 5272 23 in in IN cord-023095-4dannjjm 5272 24 normovolemic normovolemic JJ cord-023095-4dannjjm 5272 25 feline feline JJ cord-023095-4dannjjm 5272 26 and and CC cord-023095-4dannjjm 5272 27 canine canine JJ cord-023095-4dannjjm 5272 28 patients patient NNS cord-023095-4dannjjm 5272 29 . . . cord-023095-4dannjjm 5273 1 After after IN cord-023095-4dannjjm 5273 2 a a DT cord-023095-4dannjjm 5273 3 purposely purposely RB cord-023095-4dannjjm 5273 4 limited limit VBN cord-023095-4dannjjm 5273 5 training training NN cord-023095-4dannjjm 5273 6 period period NN cord-023095-4dannjjm 5273 7 , , , cord-023095-4dannjjm 5273 8 a a DT cord-023095-4dannjjm 5273 9 preclinical preclinical JJ cord-023095-4dannjjm 5273 10 veterinary veterinary JJ cord-023095-4dannjjm 5273 11 student student NN cord-023095-4dannjjm 5273 12 was be VBD cord-023095-4dannjjm 5273 13 timed time VBN cord-023095-4dannjjm 5273 14 and and CC cord-023095-4dannjjm 5273 15 video video NN cord-023095-4dannjjm 5273 16 - - HYPH cord-023095-4dannjjm 5273 17 recorded record VBN cord-023095-4dannjjm 5273 18 as as IN cord-023095-4dannjjm 5273 19 she -PRON- PRP cord-023095-4dannjjm 5273 20 performed perform VBD cord-023095-4dannjjm 5273 21 20 20 CD cord-023095-4dannjjm 5273 22 IO io NN cord-023095-4dannjjm 5273 23 catheter catheter NN cord-023095-4dannjjm 5273 24 placements placement NNS cord-023095-4dannjjm 5273 25 in in IN cord-023095-4dannjjm 5273 26 feline feline JJ cord-023095-4dannjjm 5273 27 cadavers cadaver NNS cord-023095-4dannjjm 5273 28 ( ( -LRB- cord-023095-4dannjjm 5273 29 10 10 CD cord-023095-4dannjjm 5273 30 IO IO NNP cord-023095-4dannjjm 5273 31 insertions insertion NNS cord-023095-4dannjjm 5273 32 by by IN cord-023095-4dannjjm 5273 33 placing place VBG cord-023095-4dannjjm 5273 34 an an DT cord-023095-4dannjjm 5273 35 Illinois Illinois NNP cord-023095-4dannjjm 5273 36 needle needle NN cord-023095-4dannjjm 5273 37 manually manually RB cord-023095-4dannjjm 5273 38 and and CC cord-023095-4dannjjm 5273 39 10 10 CD cord-023095-4dannjjm 5273 40 IO IO NNP cord-023095-4dannjjm 5273 41 insertions insertion NNS cord-023095-4dannjjm 5273 42 using use VBG cord-023095-4dannjjm 5273 43 the the DT cord-023095-4dannjjm 5273 44 EZ EZ NNP cord-023095-4dannjjm 5273 45 - - HYPH cord-023095-4dannjjm 5273 46 IO IO NNP cord-023095-4dannjjm 5273 47 G3 G3 NNP cord-023095-4dannjjm 5273 48 ) ) -RRB- cord-023095-4dannjjm 5273 49 . . . cord-023095-4dannjjm 5274 1 Order order NN cord-023095-4dannjjm 5274 2 of of IN cord-023095-4dannjjm 5274 3 technique technique NN cord-023095-4dannjjm 5274 4 ( ( -LRB- cord-023095-4dannjjm 5274 5 manual manual JJ cord-023095-4dannjjm 5274 6 or or CC cord-023095-4dannjjm 5274 7 EZ EZ NNP cord-023095-4dannjjm 5274 8 - - HYPH cord-023095-4dannjjm 5274 9 IO IO NNP cord-023095-4dannjjm 5274 10 G3 G3 NNP cord-023095-4dannjjm 5274 11 ) ) -RRB- cord-023095-4dannjjm 5274 12 , , , cord-023095-4dannjjm 5274 13 site site NN cord-023095-4dannjjm 5274 14 of of IN cord-023095-4dannjjm 5274 15 IO IO NNP cord-023095-4dannjjm 5274 16 placement placement NN cord-023095-4dannjjm 5274 17 ( ( -LRB- cord-023095-4dannjjm 5274 18 proximal proximal JJ cord-023095-4dannjjm 5274 19 humerus humerus NNP cord-023095-4dannjjm 5274 20 or or CC cord-023095-4dannjjm 5274 21 trochanteric trochanteric JJ cord-023095-4dannjjm 5274 22 fossa fossa NN cord-023095-4dannjjm 5274 23 of of IN cord-023095-4dannjjm 5274 24 the the DT cord-023095-4dannjjm 5274 25 femur femur NN cord-023095-4dannjjm 5274 26 ) ) -RRB- cord-023095-4dannjjm 5274 27 , , , cord-023095-4dannjjm 5274 28 and and CC cord-023095-4dannjjm 5274 29 side side NN cord-023095-4dannjjm 5274 30 of of IN cord-023095-4dannjjm 5274 31 cat cat NN cord-023095-4dannjjm 5274 32 ( ( -LRB- cord-023095-4dannjjm 5274 33 right right UH cord-023095-4dannjjm 5274 34 or or CC cord-023095-4dannjjm 5274 35 left left JJ cord-023095-4dannjjm 5274 36 ) ) -RRB- cord-023095-4dannjjm 5274 37 were be VBD cord-023095-4dannjjm 5274 38 randomized randomize VBN cord-023095-4dannjjm 5274 39 for for IN cord-023095-4dannjjm 5274 40 each each DT cord-023095-4dannjjm 5274 41 attempt attempt NN cord-023095-4dannjjm 5274 42 . . . cord-023095-4dannjjm 5275 1 When when WRB cord-023095-4dannjjm 5275 2 using use VBG cord-023095-4dannjjm 5275 3 the the DT cord-023095-4dannjjm 5275 4 EZ EZ NNP cord-023095-4dannjjm 5275 5 - - HYPH cord-023095-4dannjjm 5275 6 IO IO NNP cord-023095-4dannjjm 5275 7 G3 G3 NNP cord-023095-4dannjjm 5275 8 , , , cord-023095-4dannjjm 5275 9 a a DT cord-023095-4dannjjm 5275 10 15 15 CD cord-023095-4dannjjm 5275 11 gauge gauge NN cord-023095-4dannjjm 5275 12 x x SYM cord-023095-4dannjjm 5275 13 15 15 CD cord-023095-4dannjjm 5275 14 mm mm NN cord-023095-4dannjjm 5275 15 long long JJ cord-023095-4dannjjm 5275 16 needle needle NN cord-023095-4dannjjm 5275 17 and and CC cord-023095-4dannjjm 5275 18 a a DT cord-023095-4dannjjm 5275 19 15 15 CD cord-023095-4dannjjm 5275 20 gauge gauge NN cord-023095-4dannjjm 5275 21 x x SYM cord-023095-4dannjjm 5275 22 25 25 CD cord-023095-4dannjjm 5275 23 mm mm CD cord-023095-4dannjjm 5275 24 needle needle NN cord-023095-4dannjjm 5275 25 were be VBD cord-023095-4dannjjm 5275 26 used use VBN cord-023095-4dannjjm 5275 27 for for IN cord-023095-4dannjjm 5275 28 IO IO NNP cord-023095-4dannjjm 5275 29 catheter catheter NN cord-023095-4dannjjm 5275 30 insertion insertion NN cord-023095-4dannjjm 5275 31 in in IN cord-023095-4dannjjm 5275 32 the the DT cord-023095-4dannjjm 5275 33 humerus humerus NN cord-023095-4dannjjm 5275 34 and and CC cord-023095-4dannjjm 5275 35 femur femur NN cord-023095-4dannjjm 5275 36 , , , cord-023095-4dannjjm 5275 37 respectively respectively RB cord-023095-4dannjjm 5275 38 . . . cord-023095-4dannjjm 5276 1 After after IN cord-023095-4dannjjm 5276 2 each each DT cord-023095-4dannjjm 5276 3 attempt attempt NN cord-023095-4dannjjm 5276 4 , , , cord-023095-4dannjjm 5276 5 the the DT cord-023095-4dannjjm 5276 6 student student NN cord-023095-4dannjjm 5276 7 graded grade VBD cord-023095-4dannjjm 5276 8 the the DT cord-023095-4dannjjm 5276 9 ' ' '' cord-023095-4dannjjm 5276 10 ' ' '' cord-023095-4dannjjm 5276 11 ease ease NN cord-023095-4dannjjm 5276 12 of of IN cord-023095-4dannjjm 5276 13 use use NN cord-023095-4dannjjm 5276 14 ' ' '' cord-023095-4dannjjm 5276 15 ' ' '' cord-023095-4dannjjm 5276 16 of of IN cord-023095-4dannjjm 5276 17 each each DT cord-023095-4dannjjm 5276 18 technique technique NN cord-023095-4dannjjm 5276 19 on on IN cord-023095-4dannjjm 5276 20 a a DT cord-023095-4dannjjm 5276 21 visual visual JJ cord-023095-4dannjjm 5276 22 analog analog NN cord-023095-4dannjjm 5276 23 scale scale NN cord-023095-4dannjjm 5276 24 ( ( -LRB- cord-023095-4dannjjm 5276 25 VAS VAS NNP cord-023095-4dannjjm 5276 26 ) ) -RRB- cord-023095-4dannjjm 5276 27 that that WDT cord-023095-4dannjjm 5276 28 was be VBD cord-023095-4dannjjm 5276 29 converted convert VBN cord-023095-4dannjjm 5276 30 to to IN cord-023095-4dannjjm 5276 31 a a DT cord-023095-4dannjjm 5276 32 5-point 5-point CD cord-023095-4dannjjm 5276 33 scale scale NN cord-023095-4dannjjm 5276 34 . . . cord-023095-4dannjjm 5277 1 Twenty twenty CD cord-023095-4dannjjm 5277 2 - - HYPH cord-023095-4dannjjm 5277 3 six six CD cord-023095-4dannjjm 5277 4 IV IV NNP cord-023095-4dannjjm 5277 5 catheter catheter NN cord-023095-4dannjjm 5277 6 insertions insertion NNS cord-023095-4dannjjm 5277 7 in in IN cord-023095-4dannjjm 5277 8 normovolemic normovolemic JJ cord-023095-4dannjjm 5277 9 feline feline JJ cord-023095-4dannjjm 5277 10 and and CC cord-023095-4dannjjm 5277 11 canine canine JJ cord-023095-4dannjjm 5277 12 patients patient NNS cord-023095-4dannjjm 5277 13 performed perform VBN cord-023095-4dannjjm 5277 14 by by IN cord-023095-4dannjjm 5277 15 Western Western NNP cord-023095-4dannjjm 5277 16 College College NNP cord-023095-4dannjjm 5277 17 of of IN cord-023095-4dannjjm 5277 18 Veterinary Veterinary NNP cord-023095-4dannjjm 5277 19 Medicine Medicine NNP cord-023095-4dannjjm 5277 20 ( ( -LRB- cord-023095-4dannjjm 5277 21 WCVM WCVM NNP cord-023095-4dannjjm 5277 22 ) ) -RRB- cord-023095-4dannjjm 5277 23 Small Small NNP cord-023095-4dannjjm 5277 24 Animal Animal NNP cord-023095-4dannjjm 5277 25 Hospital Hospital NNP cord-023095-4dannjjm 5277 26 personnel personnel NNS cord-023095-4dannjjm 5277 27 ( ( -LRB- cord-023095-4dannjjm 5277 28 6 6 CD cord-023095-4dannjjm 5277 29 technicians technician NNS cord-023095-4dannjjm 5277 30 , , , cord-023095-4dannjjm 5277 31 16 16 CD cord-023095-4dannjjm 5277 32 veterinary veterinary JJ cord-023095-4dannjjm 5277 33 students student NNS cord-023095-4dannjjm 5277 34 , , , cord-023095-4dannjjm 5277 35 1 1 CD cord-023095-4dannjjm 5277 36 intern intern NN cord-023095-4dannjjm 5277 37 , , , cord-023095-4dannjjm 5277 38 1 1 CD cord-023095-4dannjjm 5277 39 resident resident NN cord-023095-4dannjjm 5277 40 , , , cord-023095-4dannjjm 5277 41 2 2 CD cord-023095-4dannjjm 5277 42 clinicians clinician NNS cord-023095-4dannjjm 5277 43 ) ) -RRB- cord-023095-4dannjjm 5277 44 were be VBD cord-023095-4dannjjm 5277 45 then then RB cord-023095-4dannjjm 5277 46 timed time VBN cord-023095-4dannjjm 5277 47 and and CC cord-023095-4dannjjm 5277 48 compared compare VBN cord-023095-4dannjjm 5277 49 to to IN cord-023095-4dannjjm 5277 50 the the DT cord-023095-4dannjjm 5277 51 student student NN cord-023095-4dannjjm 5277 52 's 's POS cord-023095-4dannjjm 5277 53 mean mean JJ cord-023095-4dannjjm 5277 54 IO IO NNP cord-023095-4dannjjm 5277 55 catheter catheter NN cord-023095-4dannjjm 5277 56 insertion insertion NN cord-023095-4dannjjm 5277 57 time time NN cord-023095-4dannjjm 5277 58 using use VBG cord-023095-4dannjjm 5277 59 the the DT cord-023095-4dannjjm 5277 60 EZ EZ NNP cord-023095-4dannjjm 5277 61 - - HYPH cord-023095-4dannjjm 5277 62 IO IO NNP cord-023095-4dannjjm 5277 63 G3.Median g3.median JJ cord-023095-4dannjjm 5277 64 IO io NN cord-023095-4dannjjm 5277 65 catheter catheter NN cord-023095-4dannjjm 5277 66 insertion insertion NN cord-023095-4dannjjm 5277 67 times time NNS cord-023095-4dannjjm 5277 68 for for IN cord-023095-4dannjjm 5277 69 the the DT cord-023095-4dannjjm 5277 70 2 2 CD cord-023095-4dannjjm 5277 71 techniques technique NNS cord-023095-4dannjjm 5277 72 were be VBD cord-023095-4dannjjm 5277 73 significantly significantly RB cord-023095-4dannjjm 5277 74 different different JJ cord-023095-4dannjjm 5277 75 ( ( -LRB- cord-023095-4dannjjm 5277 76 manual manual JJ cord-023095-4dannjjm 5277 77 IO IO NNP cord-023095-4dannjjm 5277 78 technique technique NN cord-023095-4dannjjm 5277 79 24 24 CD cord-023095-4dannjjm 5277 80 sec sec NNP cord-023095-4dannjjm 5277 81 ; ; : cord-023095-4dannjjm 5277 82 EZ EZ NNP cord-023095-4dannjjm 5277 83 - - HYPH cord-023095-4dannjjm 5277 84 IO IO NNP cord-023095-4dannjjm 5277 85 G3 G3 NNP cord-023095-4dannjjm 5277 86 5 5 CD cord-023095-4dannjjm 5277 87 sec sec NNP cord-023095-4dannjjm 5277 88 ) ) -RRB- cord-023095-4dannjjm 5278 1 ( ( -LRB- cord-023095-4dannjjm 5278 2 p p NN cord-023095-4dannjjm 5278 3 o o CD cord-023095-4dannjjm 5278 4 0.001 0.001 CD cord-023095-4dannjjm 5278 5 ) ) -RRB- cord-023095-4dannjjm 5278 6 ; ; : cord-023095-4dannjjm 5278 7 the the DT cord-023095-4dannjjm 5278 8 manual manual JJ cord-023095-4dannjjm 5278 9 method method NN cord-023095-4dannjjm 5278 10 took take VBD cord-023095-4dannjjm 5278 11 48 48 CD cord-023095-4dannjjm 5278 12 seconds second NNS cord-023095-4dannjjm 5278 13 longer long JJR cord-023095-4dannjjm 5278 14 ( ( -LRB- cord-023095-4dannjjm 5278 15 95 95 CD cord-023095-4dannjjm 5278 16 % % NN cord-023095-4dannjjm 5278 17 confidence confidence NN cord-023095-4dannjjm 5278 18 interval interval NN cord-023095-4dannjjm 5278 19 of of IN cord-023095-4dannjjm 5278 20 28 28 CD cord-023095-4dannjjm 5278 21 to to TO cord-023095-4dannjjm 5278 22 67 67 CD cord-023095-4dannjjm 5278 23 seconds second NNS cord-023095-4dannjjm 5278 24 ) ) -RRB- cord-023095-4dannjjm 5278 25 than than IN cord-023095-4dannjjm 5278 26 the the DT cord-023095-4dannjjm 5278 27 EZ EZ NNP cord-023095-4dannjjm 5278 28 - - HYPH cord-023095-4dannjjm 5278 29 IO IO NNP cord-023095-4dannjjm 5278 30 G3 G3 NNP cord-023095-4dannjjm 5278 31 method method NN cord-023095-4dannjjm 5278 32 . . . cord-023095-4dannjjm 5279 1 Insertion insertion NN cord-023095-4dannjjm 5279 2 time time NN cord-023095-4dannjjm 5279 3 was be VBD cord-023095-4dannjjm 5279 4 more more RBR cord-023095-4dannjjm 5279 5 variable variable JJ cord-023095-4dannjjm 5279 6 for for IN cord-023095-4dannjjm 5279 7 the the DT cord-023095-4dannjjm 5279 8 manual manual JJ cord-023095-4dannjjm 5279 9 technique technique NN cord-023095-4dannjjm 5279 10 than than IN cord-023095-4dannjjm 5279 11 for for IN cord-023095-4dannjjm 5279 12 the the DT cord-023095-4dannjjm 5279 13 EZ EZ NNP cord-023095-4dannjjm 5279 14 - - HYPH cord-023095-4dannjjm 5279 15 IO IO NNP cord-023095-4dannjjm 5279 16 G3 G3 NNP cord-023095-4dannjjm 5279 17 . . . cord-023095-4dannjjm 5280 1 Percentage percentage NN cord-023095-4dannjjm 5280 2 of of IN cord-023095-4dannjjm 5280 3 catheter catheter NN cord-023095-4dannjjm 5280 4 ' ' '' cord-023095-4dannjjm 5280 5 ' ' '' cord-023095-4dannjjm 5280 6 slippage slippage NN cord-023095-4dannjjm 5280 7 off off IN cord-023095-4dannjjm 5280 8 the the DT cord-023095-4dannjjm 5280 9 bone bone NN cord-023095-4dannjjm 5280 10 ' ' '' cord-023095-4dannjjm 5280 11 ' ' '' cord-023095-4dannjjm 5280 12 and and CC cord-023095-4dannjjm 5280 13 extravasation extravasation NN cord-023095-4dannjjm 5280 14 around around IN cord-023095-4dannjjm 5280 15 the the DT cord-023095-4dannjjm 5280 16 inserted insert VBN cord-023095-4dannjjm 5280 17 catheter catheter NN cord-023095-4dannjjm 5280 18 were be VBD cord-023095-4dannjjm 5280 19 significantly significantly RB cord-023095-4dannjjm 5280 20 higher high JJR cord-023095-4dannjjm 5280 21 for for IN cord-023095-4dannjjm 5280 22 placement placement NN cord-023095-4dannjjm 5280 23 of of IN cord-023095-4dannjjm 5280 24 the the DT cord-023095-4dannjjm 5280 25 manual manual JJ cord-023095-4dannjjm 5280 26 IO IO NNP cord-023095-4dannjjm 5280 27 catheter catheter NN cord-023095-4dannjjm 5280 28 compared compare VBN cord-023095-4dannjjm 5280 29 with with IN cord-023095-4dannjjm 5280 30 placement placement NN cord-023095-4dannjjm 5280 31 of of IN cord-023095-4dannjjm 5280 32 the the DT cord-023095-4dannjjm 5280 33 EZ EZ NNP cord-023095-4dannjjm 5280 34 - - HYPH cord-023095-4dannjjm 5280 35 IO IO NNP cord-023095-4dannjjm 5280 36 G3 G3 NNP cord-023095-4dannjjm 5280 37 catheter catheter NN cord-023095-4dannjjm 5280 38 ( ( -LRB- cord-023095-4dannjjm 5281 1 p p NN cord-023095-4dannjjm 5281 2 o o NN cord-023095-4dannjjm 5281 3 0.001 0.001 CD cord-023095-4dannjjm 5281 4 ) ) -RRB- cord-023095-4dannjjm 5281 5 . . . cord-023095-4dannjjm 5282 1 Student student NN cord-023095-4dannjjm 5282 2 's 's POS cord-023095-4dannjjm 5282 3 subjective subjective JJ cord-023095-4dannjjm 5282 4 ratings rating NNS cord-023095-4dannjjm 5282 5 were be VBD cord-023095-4dannjjm 5282 6 more more RBR cord-023095-4dannjjm 5282 7 favorable favorable JJ cord-023095-4dannjjm 5282 8 and and CC cord-023095-4dannjjm 5282 9 more more RBR cord-023095-4dannjjm 5282 10 consistent consistent JJ cord-023095-4dannjjm 5282 11 for for IN cord-023095-4dannjjm 5282 12 the the DT cord-023095-4dannjjm 5282 13 EZ EZ NNP cord-023095-4dannjjm 5282 14 - - HYPH cord-023095-4dannjjm 5282 15 IO IO NNP cord-023095-4dannjjm 5282 16 G3 G3 NNP cord-023095-4dannjjm 5282 17 technique technique NN cord-023095-4dannjjm 5282 18 compared compare VBN cord-023095-4dannjjm 5282 19 to to IN cord-023095-4dannjjm 5282 20 the the DT cord-023095-4dannjjm 5282 21 manual manual JJ cord-023095-4dannjjm 5282 22 technique technique NN cord-023095-4dannjjm 5282 23 for for IN cord-023095-4dannjjm 5282 24 IO IO NNP cord-023095-4dannjjm 5282 25 catheter catheter NN cord-023095-4dannjjm 5282 26 insertion insertion NN cord-023095-4dannjjm 5282 27 . . . cord-023095-4dannjjm 5283 1 Compared compare VBN cord-023095-4dannjjm 5283 2 to to IN cord-023095-4dannjjm 5283 3 the the DT cord-023095-4dannjjm 5283 4 mean mean JJ cord-023095-4dannjjm 5283 5 insertion insertion NN cord-023095-4dannjjm 5283 6 time time NN cord-023095-4dannjjm 5283 7 for for IN cord-023095-4dannjjm 5283 8 IV IV NNP cord-023095-4dannjjm 5283 9 catheterization catheterization NN cord-023095-4dannjjm 5283 10 in in IN cord-023095-4dannjjm 5283 11 the the DT cord-023095-4dannjjm 5283 12 WCVM WCVM NNP cord-023095-4dannjjm 5283 13 Small Small NNP cord-023095-4dannjjm 5283 14 Animal Animal NNP cord-023095-4dannjjm 5283 15 Hospital Hospital NNP cord-023095-4dannjjm 5283 16 , , , cord-023095-4dannjjm 5283 17 IO IO NNP cord-023095-4dannjjm 5283 18 catheter catheter NN cord-023095-4dannjjm 5283 19 insertion insertion NN cord-023095-4dannjjm 5283 20 by by IN cord-023095-4dannjjm 5283 21 the the DT cord-023095-4dannjjm 5283 22 student student NN cord-023095-4dannjjm 5283 23 using use VBG cord-023095-4dannjjm 5283 24 the the DT cord-023095-4dannjjm 5283 25 EZ EZ NNP cord-023095-4dannjjm 5283 26 - - HYPH cord-023095-4dannjjm 5283 27 IO IO NNP cord-023095-4dannjjm 5283 28 G3 G3 NNP cord-023095-4dannjjm 5283 29 was be VBD cord-023095-4dannjjm 5283 30 significantly significantly RB cord-023095-4dannjjm 5283 31 faster fast JJR cord-023095-4dannjjm 5284 1 ( ( -LRB- cord-023095-4dannjjm 5284 2 IV IV NNP cord-023095-4dannjjm 5284 3 catheter catheter NN cord-023095-4dannjjm 5284 4 188 188 CD cord-023095-4dannjjm 5284 5 sec sec NNP cord-023095-4dannjjm 5285 1 ; ; : cord-023095-4dannjjm 5285 2 EZ EZ NNP cord-023095-4dannjjm 5285 3 - - HYPH cord-023095-4dannjjm 5285 4 IO IO NNP cord-023095-4dannjjm 5285 5 G3 G3 NNP cord-023095-4dannjjm 5285 6 IO IO NNP cord-023095-4dannjjm 5285 7 catheter catheter NN cord-023095-4dannjjm 5285 8 7 7 CD cord-023095-4dannjjm 5285 9 sec sec NNP cord-023095-4dannjjm 5285 10 ) ) -RRB- cord-023095-4dannjjm 5286 1 ( ( -LRB- cord-023095-4dannjjm 5286 2 p p NN cord-023095-4dannjjm 5286 3 o o CD cord-023095-4dannjjm 5286 4 0.001 0.001 CD cord-023095-4dannjjm 5286 5 ) ) -RRB- cord-023095-4dannjjm 5286 6 . . . cord-023095-4dannjjm 5287 1 Intraosseous intraosseous JJ cord-023095-4dannjjm 5287 2 catheter catheter NN cord-023095-4dannjjm 5287 3 insertion insertion NN cord-023095-4dannjjm 5287 4 using use VBG cord-023095-4dannjjm 5287 5 the the DT cord-023095-4dannjjm 5287 6 EZ EZ NNP cord-023095-4dannjjm 5287 7 - - HYPH cord-023095-4dannjjm 5287 8 IO IO NNP cord-023095-4dannjjm 5287 9 G3 G3 NNP cord-023095-4dannjjm 5287 10 can can MD cord-023095-4dannjjm 5287 11 be be VB cord-023095-4dannjjm 5287 12 said say VBN cord-023095-4dannjjm 5287 13 to to TO cord-023095-4dannjjm 5287 14 be be VB cord-023095-4dannjjm 5287 15 significantly significantly RB cord-023095-4dannjjm 5287 16 faster fast JJR cord-023095-4dannjjm 5287 17 , , , cord-023095-4dannjjm 5287 18 less less RBR cord-023095-4dannjjm 5287 19 traumatic traumatic JJ cord-023095-4dannjjm 5287 20 , , , cord-023095-4dannjjm 5287 21 more more JJR cord-023095-4dannjjm 5287 22 user user NN cord-023095-4dannjjm 5287 23 - - HYPH cord-023095-4dannjjm 5287 24 friendly friendly JJ cord-023095-4dannjjm 5287 25 , , , cord-023095-4dannjjm 5287 26 and and CC cord-023095-4dannjjm 5287 27 as as RB cord-023095-4dannjjm 5287 28 effective effective JJ cord-023095-4dannjjm 5287 29 as as IN cord-023095-4dannjjm 5287 30 IO IO NNP cord-023095-4dannjjm 5287 31 catheter catheter NN cord-023095-4dannjjm 5287 32 placement placement NN cord-023095-4dannjjm 5287 33 using use VBG cord-023095-4dannjjm 5287 34 the the DT cord-023095-4dannjjm 5287 35 manual manual JJ cord-023095-4dannjjm 5287 36 technique technique NN cord-023095-4dannjjm 5287 37 . . . cord-023095-4dannjjm 5288 1 Vascular vascular JJ cord-023095-4dannjjm 5288 2 access access NN cord-023095-4dannjjm 5288 3 via via IN cord-023095-4dannjjm 5288 4 IO IO NNP cord-023095-4dannjjm 5288 5 catheter catheter NN cord-023095-4dannjjm 5288 6 insertion insertion NN cord-023095-4dannjjm 5288 7 using use VBG cord-023095-4dannjjm 5288 8 the the DT cord-023095-4dannjjm 5288 9 EZ EZ NNP cord-023095-4dannjjm 5288 10 - - HYPH cord-023095-4dannjjm 5288 11 IO IO NNP cord-023095-4dannjjm 5288 12 G3 G3 NNP cord-023095-4dannjjm 5288 13 device device NN cord-023095-4dannjjm 5288 14 may may MD cord-023095-4dannjjm 5288 15 be be VB cord-023095-4dannjjm 5288 16 suggested suggest VBN cord-023095-4dannjjm 5288 17 to to TO cord-023095-4dannjjm 5288 18 be be VB cord-023095-4dannjjm 5288 19 faster fast JJR cord-023095-4dannjjm 5288 20 than than IN cord-023095-4dannjjm 5288 21 IV IV NNP cord-023095-4dannjjm 5288 22 catheter catheter NN cord-023095-4dannjjm 5288 23 insertion insertion NN cord-023095-4dannjjm 5288 24 . . . cord-023095-4dannjjm 5289 1 Previously previously RB cord-023095-4dannjjm 5289 2 presented present VBN cord-023095-4dannjjm 5289 3 at at IN cord-023095-4dannjjm 5289 4 the the DT cord-023095-4dannjjm 5289 5 Western Western NNP cord-023095-4dannjjm 5289 6 College College NNP cord-023095-4dannjjm 5289 7 of of IN cord-023095-4dannjjm 5289 8 Veterinary Veterinary NNP cord-023095-4dannjjm 5289 9 Medicine Medicine NNP cord-023095-4dannjjm 5289 10 Undergraduate Undergraduate NNP cord-023095-4dannjjm 5289 11 Poster Poster NNP cord-023095-4dannjjm 5289 12 Competition Competition NNP cord-023095-4dannjjm 5289 13 . . . cord-023095-4dannjjm 5290 1 Computed compute VBN cord-023095-4dannjjm 5290 2 tomography tomography NN cord-023095-4dannjjm 5290 3 ( ( -LRB- cord-023095-4dannjjm 5290 4 CT CT NNP cord-023095-4dannjjm 5290 5 ) ) -RRB- cord-023095-4dannjjm 5290 6 has have VBZ cord-023095-4dannjjm 5290 7 been be VBN cord-023095-4dannjjm 5290 8 widely widely RB cord-023095-4dannjjm 5290 9 investigated investigate VBN cord-023095-4dannjjm 5290 10 and and CC cord-023095-4dannjjm 5290 11 applied apply VBD cord-023095-4dannjjm 5290 12 as as IN cord-023095-4dannjjm 5290 13 a a DT cord-023095-4dannjjm 5290 14 means means NN cord-023095-4dannjjm 5290 15 for for IN cord-023095-4dannjjm 5290 16 non non JJ cord-023095-4dannjjm 5290 17 - - JJ cord-023095-4dannjjm 5290 18 invasive invasive JJ cord-023095-4dannjjm 5290 19 quantitative quantitative JJ cord-023095-4dannjjm 5290 20 bone bone NN cord-023095-4dannjjm 5290 21 mineral mineral NN cord-023095-4dannjjm 5290 22 determination determination NN cord-023095-4dannjjm 5290 23 in in IN cord-023095-4dannjjm 5290 24 human human JJ cord-023095-4dannjjm 5290 25 medicine medicine NN cord-023095-4dannjjm 5290 26 . . . cord-023095-4dannjjm 5291 1 The the DT cord-023095-4dannjjm 5291 2 aim aim NN cord-023095-4dannjjm 5291 3 of of IN cord-023095-4dannjjm 5291 4 this this DT cord-023095-4dannjjm 5291 5 study study NN cord-023095-4dannjjm 5291 6 was be VBD cord-023095-4dannjjm 5291 7 to to TO cord-023095-4dannjjm 5291 8 assess assess VB cord-023095-4dannjjm 5291 9 age age NN cord-023095-4dannjjm 5291 10 - - HYPH cord-023095-4dannjjm 5291 11 related relate VBN cord-023095-4dannjjm 5291 12 changes change NNS cord-023095-4dannjjm 5291 13 and and CC cord-023095-4dannjjm 5291 14 anatomic anatomic JJ cord-023095-4dannjjm 5291 15 variation variation NN cord-023095-4dannjjm 5291 16 in in IN cord-023095-4dannjjm 5291 17 bone bone NN cord-023095-4dannjjm 5291 18 mineral mineral NN cord-023095-4dannjjm 5291 19 density density NN cord-023095-4dannjjm 5291 20 ( ( -LRB- cord-023095-4dannjjm 5291 21 BMD BMD NNP cord-023095-4dannjjm 5291 22 ) ) -RRB- cord-023095-4dannjjm 5291 23 using use VBG cord-023095-4dannjjm 5291 24 quantitative quantitative JJ cord-023095-4dannjjm 5291 25 CT CT NNP cord-023095-4dannjjm 5291 26 in in IN cord-023095-4dannjjm 5291 27 normal normal JJ cord-023095-4dannjjm 5291 28 cats cat NNS cord-023095-4dannjjm 5291 29 . . . cord-023095-4dannjjm 5292 1 Seventeen seventeen CD cord-023095-4dannjjm 5292 2 normal normal JJ cord-023095-4dannjjm 5292 3 cats cat NNS cord-023095-4dannjjm 5292 4 were be VBD cord-023095-4dannjjm 5292 5 included include VBN cord-023095-4dannjjm 5292 6 in in IN cord-023095-4dannjjm 5292 7 this this DT cord-023095-4dannjjm 5292 8 study study NN cord-023095-4dannjjm 5292 9 and and CC cord-023095-4dannjjm 5292 10 divided divide VBD cord-023095-4dannjjm 5292 11 into into IN cord-023095-4dannjjm 5292 12 the the DT cord-023095-4dannjjm 5292 13 following following JJ cord-023095-4dannjjm 5292 14 3 3 CD cord-023095-4dannjjm 5292 15 age age NN cord-023095-4dannjjm 5292 16 groups group NNS cord-023095-4dannjjm 5292 17 : : : cord-023095-4dannjjm 5293 1 o o NN cord-023095-4dannjjm 5293 2 1 1 CD cord-023095-4dannjjm 5293 3 year year NN cord-023095-4dannjjm 5294 1 ( ( -LRB- cord-023095-4dannjjm 5294 2 n n NN cord-023095-4dannjjm 5294 3 5 5 CD cord-023095-4dannjjm 5294 4 4 4 CD cord-023095-4dannjjm 5294 5 ) ) -RRB- cord-023095-4dannjjm 5294 6 ; ; : cord-023095-4dannjjm 5294 7 2 2 CD cord-023095-4dannjjm 5294 8 - - SYM cord-023095-4dannjjm 5294 9 5 5 CD cord-023095-4dannjjm 5294 10 years year NNS cord-023095-4dannjjm 5294 11 ( ( -LRB- cord-023095-4dannjjm 5294 12 n n NN cord-023095-4dannjjm 5294 13 5 5 CD cord-023095-4dannjjm 5294 14 10 10 CD cord-023095-4dannjjm 5294 15 ) ) -RRB- cord-023095-4dannjjm 5294 16 ; ; : cord-023095-4dannjjm 5294 17 and and CC cord-023095-4dannjjm 5294 18 4 4 CD cord-023095-4dannjjm 5294 19 6 6 CD cord-023095-4dannjjm 5294 20 years year NNS cord-023095-4dannjjm 5294 21 ( ( -LRB- cord-023095-4dannjjm 5294 22 n n NN cord-023095-4dannjjm 5294 23 5 5 CD cord-023095-4dannjjm 5294 24 3 3 CD cord-023095-4dannjjm 5294 25 ) ) -RRB- cord-023095-4dannjjm 5294 26 . . . cord-023095-4dannjjm 5295 1 A a DT cord-023095-4dannjjm 5295 2 computed compute VBN cord-023095-4dannjjm 5295 3 tomographic tomographic NN cord-023095-4dannjjm 5295 4 scan scan NN cord-023095-4dannjjm 5295 5 of of IN cord-023095-4dannjjm 5295 6 each each DT cord-023095-4dannjjm 5295 7 vertebra vertebra NN cord-023095-4dannjjm 5295 8 from from IN cord-023095-4dannjjm 5295 9 the the DT cord-023095-4dannjjm 5295 10 12 12 CD cord-023095-4dannjjm 5295 11 th th XX cord-023095-4dannjjm 5295 12 thoracic thoracic NN cord-023095-4dannjjm 5295 13 to to IN cord-023095-4dannjjm 5295 14 the the DT cord-023095-4dannjjm 5295 15 7 7 CD cord-023095-4dannjjm 5295 16 th th XX cord-023095-4dannjjm 5295 17 lumbar lumbar NN cord-023095-4dannjjm 5295 18 spine spine NN cord-023095-4dannjjm 5295 19 , , , cord-023095-4dannjjm 5295 20 and and CC cord-023095-4dannjjm 5295 21 the the DT cord-023095-4dannjjm 5295 22 pelvis pelvi NNS cord-023095-4dannjjm 5295 23 , , , cord-023095-4dannjjm 5295 24 was be VBD cord-023095-4dannjjm 5295 25 performed perform VBN cord-023095-4dannjjm 5295 26 with with IN cord-023095-4dannjjm 5295 27 a a DT cord-023095-4dannjjm 5295 28 bone bone NN cord-023095-4dannjjm 5295 29 - - HYPH cord-023095-4dannjjm 5295 30 density density NN cord-023095-4dannjjm 5295 31 phantom phantom NN cord-023095-4dannjjm 5295 32 ( ( -LRB- cord-023095-4dannjjm 5295 33 50 50 CD cord-023095-4dannjjm 5295 34 , , , cord-023095-4dannjjm 5295 35 100 100 CD cord-023095-4dannjjm 5295 36 , , , cord-023095-4dannjjm 5295 37 and and CC cord-023095-4dannjjm 5295 38 150 150 CD cord-023095-4dannjjm 5295 39 mg mg NNP cord-023095-4dannjjm 5295 40 / / SYM cord-023095-4dannjjm 5295 41 cm cm NNP cord-023095-4dannjjm 5295 42 3 3 CD cord-023095-4dannjjm 5295 43 , , , cord-023095-4dannjjm 5295 44 calcium calcium NN cord-023095-4dannjjm 5295 45 hydroxyapatite hydroxyapatite NN cord-023095-4dannjjm 5295 46 , , , cord-023095-4dannjjm 5295 47 CIRS CIRS NNP cord-023095-4dannjjm 5295 48 phantom phantom NNP cord-023095-4dannjjm 5295 49 s s NNP cord-023095-4dannjjm 5295 50 ) ) -RRB- cord-023095-4dannjjm 5295 51 . . . cord-023095-4dannjjm 5296 1 On on IN cord-023095-4dannjjm 5296 2 the the DT cord-023095-4dannjjm 5296 3 central central JJ cord-023095-4dannjjm 5296 4 transverse transverse JJ cord-023095-4dannjjm 5296 5 section section NN cord-023095-4dannjjm 5296 6 , , , cord-023095-4dannjjm 5296 7 the the DT cord-023095-4dannjjm 5296 8 elliptical elliptical JJ cord-023095-4dannjjm 5296 9 region region NN cord-023095-4dannjjm 5296 10 of of IN cord-023095-4dannjjm 5296 11 interest interest NN cord-023095-4dannjjm 5296 12 ( ( -LRB- cord-023095-4dannjjm 5296 13 ROI ROI NNP cord-023095-4dannjjm 5296 14 ) ) -RRB- cord-023095-4dannjjm 5296 15 was be VBD cord-023095-4dannjjm 5296 16 drawn draw VBN cord-023095-4dannjjm 5296 17 to to TO cord-023095-4dannjjm 5296 18 measure measure VB cord-023095-4dannjjm 5296 19 the the DT cord-023095-4dannjjm 5296 20 mean mean JJ cord-023095-4dannjjm 5296 21 Hounsfield Hounsfield NNP cord-023095-4dannjjm 5296 22 unit unit NN cord-023095-4dannjjm 5296 23 value value NN cord-023095-4dannjjm 5296 24 . . . cord-023095-4dannjjm 5297 1 Those those DT cord-023095-4dannjjm 5297 2 values value NNS cord-023095-4dannjjm 5297 3 were be VBD cord-023095-4dannjjm 5297 4 converted convert VBN cord-023095-4dannjjm 5297 5 to to IN cord-023095-4dannjjm 5297 6 equivalent equivalent JJ cord-023095-4dannjjm 5297 7 BMD bmd NN cord-023095-4dannjjm 5297 8 by by IN cord-023095-4dannjjm 5297 9 use use NN cord-023095-4dannjjm 5297 10 of of IN cord-023095-4dannjjm 5297 11 the the DT cord-023095-4dannjjm 5297 12 bone bone NN cord-023095-4dannjjm 5297 13 - - HYPH cord-023095-4dannjjm 5297 14 density density NN cord-023095-4dannjjm 5297 15 phantom phantom NN cord-023095-4dannjjm 5297 16 and and CC cord-023095-4dannjjm 5297 17 linear linear JJ cord-023095-4dannjjm 5297 18 regression regression NN cord-023095-4dannjjm 5297 19 analysis analysis NN cord-023095-4dannjjm 5297 20 ( ( -LRB- cord-023095-4dannjjm 5297 21 r r NN cord-023095-4dannjjm 5297 22 2 2 CD cord-023095-4dannjjm 5297 23 4 4 CD cord-023095-4dannjjm 5297 24 0.95 0.95 CD cord-023095-4dannjjm 5297 25 ) ) -RRB- cord-023095-4dannjjm 5297 26 . . . cord-023095-4dannjjm 5298 1 The the DT cord-023095-4dannjjm 5298 2 mean mean JJ cord-023095-4dannjjm 5298 3 BMD bmd NN cord-023095-4dannjjm 5298 4 value value NN cord-023095-4dannjjm 5298 5 of of IN cord-023095-4dannjjm 5298 6 the the DT cord-023095-4dannjjm 5298 7 thoracic thoracic JJ cord-023095-4dannjjm 5298 8 vertebrae vertebrae NN cord-023095-4dannjjm 5298 9 ( ( -LRB- cord-023095-4dannjjm 5298 10 651.3 651.3 CD cord-023095-4dannjjm 5298 11 AE AE NNP cord-023095-4dannjjm 5298 12 100.4 100.4 CD cord-023095-4dannjjm 5298 13 mg mg NNP cord-023095-4dannjjm 5298 14 / / SYM cord-023095-4dannjjm 5298 15 cm cm NNP cord-023095-4dannjjm 5298 16 3 3 CD cord-023095-4dannjjm 5298 17 ) ) -RRB- cord-023095-4dannjjm 5298 18 was be VBD cord-023095-4dannjjm 5298 19 significantly significantly RB cord-023095-4dannjjm 5298 20 higher high JJR cord-023095-4dannjjm 5298 21 than than IN cord-023095-4dannjjm 5298 22 of of IN cord-023095-4dannjjm 5298 23 the the DT cord-023095-4dannjjm 5298 24 lumbar lumbar JJ cord-023095-4dannjjm 5298 25 vertebrae vertebrae NN cord-023095-4dannjjm 5298 26 ( ( -LRB- cord-023095-4dannjjm 5298 27 520 520 CD cord-023095-4dannjjm 5298 28 AE AE NNP cord-023095-4dannjjm 5298 29 119.5 119.5 CD cord-023095-4dannjjm 5298 30 mg mg NNP cord-023095-4dannjjm 5298 31 / / SYM cord-023095-4dannjjm 5298 32 cm cm NNP cord-023095-4dannjjm 5298 33 3 3 CD cord-023095-4dannjjm 5298 34 ) ) -RRB- cord-023095-4dannjjm 5298 35 . . . cord-023095-4dannjjm 5299 1 The the DT cord-023095-4dannjjm 5299 2 maximum maximum JJ cord-023095-4dannjjm 5299 3 BMD bmd NN cord-023095-4dannjjm 5299 4 occurred occur VBD cord-023095-4dannjjm 5299 5 at at IN cord-023095-4dannjjm 5299 6 the the DT cord-023095-4dannjjm 5299 7 T12 T12 NNP cord-023095-4dannjjm 5299 8 , , , cord-023095-4dannjjm 5299 9 T13 T13 NNP cord-023095-4dannjjm 5299 10 , , , cord-023095-4dannjjm 5299 11 and and CC cord-023095-4dannjjm 5299 12 L1 L1 NNP cord-023095-4dannjjm 5299 13 levels level NNS cord-023095-4dannjjm 5299 14 in in IN cord-023095-4dannjjm 5299 15 all all DT cord-023095-4dannjjm 5299 16 age age NN cord-023095-4dannjjm 5299 17 groups group NNS cord-023095-4dannjjm 5299 18 . . . cord-023095-4dannjjm 5300 1 There there EX cord-023095-4dannjjm 5300 2 was be VBD cord-023095-4dannjjm 5300 3 a a DT cord-023095-4dannjjm 5300 4 statistically statistically RB cord-023095-4dannjjm 5300 5 significant significant JJ cord-023095-4dannjjm 5300 6 difference difference NN cord-023095-4dannjjm 5300 7 in in IN cord-023095-4dannjjm 5300 8 the the DT cord-023095-4dannjjm 5300 9 mean mean JJ cord-023095-4dannjjm 5300 10 BMD bmd NN cord-023095-4dannjjm 5300 11 value value NN cord-023095-4dannjjm 5300 12 among among IN cord-023095-4dannjjm 5300 13 the the DT cord-023095-4dannjjm 5300 14 3 3 CD cord-023095-4dannjjm 5300 15 age age NN cord-023095-4dannjjm 5300 16 groups group NNS cord-023095-4dannjjm 5300 17 at at IN cord-023095-4dannjjm 5300 18 the the DT cord-023095-4dannjjm 5300 19 T12 T12 NNP cord-023095-4dannjjm 5301 1 ( ( -LRB- cord-023095-4dannjjm 5301 2 P p NN cord-023095-4dannjjm 5301 3 o o NN cord-023095-4dannjjm 5301 4 0.001 0.001 CD cord-023095-4dannjjm 5301 5 ) ) -RRB- cord-023095-4dannjjm 5301 6 , , , cord-023095-4dannjjm 5301 7 T13 T13 NNP cord-023095-4dannjjm 5301 8 ( ( -LRB- cord-023095-4dannjjm 5301 9 P p NN cord-023095-4dannjjm 5301 10 o o NN cord-023095-4dannjjm 5301 11 0.001 0.001 CD cord-023095-4dannjjm 5301 12 ) ) -RRB- cord-023095-4dannjjm 5301 13 , , , cord-023095-4dannjjm 5301 14 and and CC cord-023095-4dannjjm 5301 15 L4 l4 NN cord-023095-4dannjjm 5301 16 levels level NNS cord-023095-4dannjjm 5301 17 ( ( -LRB- cord-023095-4dannjjm 5301 18 P p NN cord-023095-4dannjjm 5301 19 5 5 CD cord-023095-4dannjjm 5301 20 0.013 0.013 CD cord-023095-4dannjjm 5301 21 ) ) -RRB- cord-023095-4dannjjm 5301 22 , , , cord-023095-4dannjjm 5301 23 respectively respectively RB cord-023095-4dannjjm 5301 24 . . . cord-023095-4dannjjm 5302 1 In in IN cord-023095-4dannjjm 5302 2 addition addition NN cord-023095-4dannjjm 5302 3 , , , cord-023095-4dannjjm 5302 4 there there EX cord-023095-4dannjjm 5302 5 was be VBD cord-023095-4dannjjm 5302 6 no no DT cord-023095-4dannjjm 5302 7 significant significant JJ cord-023095-4dannjjm 5302 8 difference difference NN cord-023095-4dannjjm 5302 9 between between IN cord-023095-4dannjjm 5302 10 the the DT cord-023095-4dannjjm 5302 11 mean mean JJ cord-023095-4dannjjm 5302 12 BMD BMD NNP cord-023095-4dannjjm 5302 13 value value NN cord-023095-4dannjjm 5302 14 of of IN cord-023095-4dannjjm 5302 15 the the DT cord-023095-4dannjjm 5302 16 left left JJ cord-023095-4dannjjm 5302 17 and and CC cord-023095-4dannjjm 5302 18 right right JJ cord-023095-4dannjjm 5302 19 iliac iliac JJ cord-023095-4dannjjm 5302 20 bodies body NNS cord-023095-4dannjjm 5302 21 ( ( -LRB- cord-023095-4dannjjm 5302 22 485.1 485.1 CD cord-023095-4dannjjm 5302 23 AE AE NNP cord-023095-4dannjjm 5302 24 140.4 140.4 CD cord-023095-4dannjjm 5302 25 mg mg NNP cord-023095-4dannjjm 5302 26 / / SYM cord-023095-4dannjjm 5302 27 cm cm NNP cord-023095-4dannjjm 5302 28 3 3 CD cord-023095-4dannjjm 5302 29 and and CC cord-023095-4dannjjm 5302 30 482.1 482.1 CD cord-023095-4dannjjm 5302 31 AE AE NNP cord-023095-4dannjjm 5303 1 148.2 148.2 CD cord-023095-4dannjjm 5304 1 mg mg NNP cord-023095-4dannjjm 5304 2 / / SYM cord-023095-4dannjjm 5304 3 cm cm NNP cord-023095-4dannjjm 5304 4 3 3 CD cord-023095-4dannjjm 5304 5 , , , cord-023095-4dannjjm 5304 6 respectively respectively RB cord-023095-4dannjjm 5304 7 ) ) -RRB- cord-023095-4dannjjm 5304 8 . . . cord-023095-4dannjjm 5305 1 The the DT cord-023095-4dannjjm 5305 2 present present JJ cord-023095-4dannjjm 5305 3 study study NN cord-023095-4dannjjm 5305 4 suggests suggest VBZ cord-023095-4dannjjm 5305 5 that that IN cord-023095-4dannjjm 5305 6 age age NN cord-023095-4dannjjm 5305 7 - - HYPH cord-023095-4dannjjm 5305 8 related relate VBN cord-023095-4dannjjm 5305 9 changes change NNS cord-023095-4dannjjm 5305 10 and and CC cord-023095-4dannjjm 5305 11 anatomic anatomic JJ cord-023095-4dannjjm 5305 12 variation variation NN cord-023095-4dannjjm 5305 13 in in IN cord-023095-4dannjjm 5305 14 BMD bmd NN cord-023095-4dannjjm 5305 15 values value NNS cord-023095-4dannjjm 5305 16 should should MD cord-023095-4dannjjm 5305 17 be be VB cord-023095-4dannjjm 5305 18 considered consider VBN cord-023095-4dannjjm 5305 19 when when WRB cord-023095-4dannjjm 5305 20 assessing assess VBG cord-023095-4dannjjm 5305 21 BMD bmd NN cord-023095-4dannjjm 5305 22 using use VBG cord-023095-4dannjjm 5305 23 quantitative quantitative JJ cord-023095-4dannjjm 5305 24 CT CT NNP cord-023095-4dannjjm 5305 25 in in IN cord-023095-4dannjjm 5305 26 cats cat NNS cord-023095-4dannjjm 5305 27 with with IN cord-023095-4dannjjm 5305 28 bone bone NN cord-023095-4dannjjm 5305 29 disorders disorder NNS cord-023095-4dannjjm 5305 30 . . . cord-023095-4dannjjm 5306 1 Dynamic dynamic JJ cord-023095-4dannjjm 5306 2 contrast contrast NN cord-023095-4dannjjm 5306 3 - - HYPH cord-023095-4dannjjm 5306 4 enhanced enhance VBN cord-023095-4dannjjm 5306 5 computed compute VBN cord-023095-4dannjjm 5306 6 tomography tomography NN cord-023095-4dannjjm 5306 7 ( ( -LRB- cord-023095-4dannjjm 5306 8 DCE DCE NNP cord-023095-4dannjjm 5306 9 - - HYPH cord-023095-4dannjjm 5306 10 CT CT NNP cord-023095-4dannjjm 5306 11 ) ) -RRB- cord-023095-4dannjjm 5306 12 is be VBZ cord-023095-4dannjjm 5306 13 a a DT cord-023095-4dannjjm 5306 14 rapid rapid JJ cord-023095-4dannjjm 5306 15 and and CC cord-023095-4dannjjm 5306 16 widely widely RB cord-023095-4dannjjm 5306 17 available available JJ cord-023095-4dannjjm 5306 18 method method NN cord-023095-4dannjjm 5306 19 of of IN cord-023095-4dannjjm 5306 20 cerebral cerebral JJ cord-023095-4dannjjm 5306 21 perfusion perfusion NN cord-023095-4dannjjm 5306 22 imaging imaging NN cord-023095-4dannjjm 5306 23 . . . cord-023095-4dannjjm 5307 1 However however RB cord-023095-4dannjjm 5307 2 , , , cord-023095-4dannjjm 5307 3 there there EX cord-023095-4dannjjm 5307 4 is be VBZ cord-023095-4dannjjm 5307 5 no no DT cord-023095-4dannjjm 5307 6 established establish VBN cord-023095-4dannjjm 5307 7 reference reference NN cord-023095-4dannjjm 5307 8 value value NN cord-023095-4dannjjm 5307 9 of of IN cord-023095-4dannjjm 5307 10 cerebral cerebral JJ cord-023095-4dannjjm 5307 11 blood blood NN cord-023095-4dannjjm 5307 12 flow flow NN cord-023095-4dannjjm 5307 13 ( ( -LRB- cord-023095-4dannjjm 5307 14 CBF CBF NNP cord-023095-4dannjjm 5307 15 ) ) -RRB- cord-023095-4dannjjm 5307 16 measured measure VBN cord-023095-4dannjjm 5307 17 by by IN cord-023095-4dannjjm 5307 18 DCE DCE NNP cord-023095-4dannjjm 5307 19 - - HYPH cord-023095-4dannjjm 5307 20 CT CT NNP cord-023095-4dannjjm 5307 21 according accord VBG cord-023095-4dannjjm 5307 22 to to IN cord-023095-4dannjjm 5307 23 a a DT cord-023095-4dannjjm 5307 24 dog dog NN cord-023095-4dannjjm 5307 25 's 's POS cord-023095-4dannjjm 5307 26 age age NN cord-023095-4dannjjm 5307 27 . . . cord-023095-4dannjjm 5308 1 The the DT cord-023095-4dannjjm 5308 2 purpose purpose NN cord-023095-4dannjjm 5308 3 of of IN cord-023095-4dannjjm 5308 4 this this DT cord-023095-4dannjjm 5308 5 study study NN cord-023095-4dannjjm 5308 6 was be VBD cord-023095-4dannjjm 5308 7 to to TO cord-023095-4dannjjm 5308 8 identify identify VB cord-023095-4dannjjm 5308 9 the the DT cord-023095-4dannjjm 5308 10 correlation correlation NN cord-023095-4dannjjm 5308 11 between between IN cord-023095-4dannjjm 5308 12 regional regional JJ cord-023095-4dannjjm 5308 13 CBF CBF NNP cord-023095-4dannjjm 5308 14 and and CC cord-023095-4dannjjm 5308 15 aging age VBG cord-023095-4dannjjm 5308 16 in in IN cord-023095-4dannjjm 5308 17 clinically clinically RB cord-023095-4dannjjm 5308 18 normal normal JJ cord-023095-4dannjjm 5308 19 dogs dog NNS cord-023095-4dannjjm 5308 20 using use VBG cord-023095-4dannjjm 5308 21 DCE DCE NNP cord-023095-4dannjjm 5308 22 - - HYPH cord-023095-4dannjjm 5308 23 CT CT NNP cord-023095-4dannjjm 5308 24 . . . cord-023095-4dannjjm 5309 1 Fourteen fourteen CD cord-023095-4dannjjm 5309 2 dogs dog NNS cord-023095-4dannjjm 5309 3 with with IN cord-023095-4dannjjm 5309 4 no no DT cord-023095-4dannjjm 5309 5 evidence evidence NN cord-023095-4dannjjm 5309 6 of of IN cord-023095-4dannjjm 5309 7 hemodynamic hemodynamic JJ cord-023095-4dannjjm 5309 8 disorders disorder NNS cord-023095-4dannjjm 5309 9 and and CC cord-023095-4dannjjm 5309 10 central central JJ cord-023095-4dannjjm 5309 11 nervous nervous JJ cord-023095-4dannjjm 5309 12 system system NN cord-023095-4dannjjm 5309 13 dysfunction dysfunction NN cord-023095-4dannjjm 5309 14 were be VBD cord-023095-4dannjjm 5309 15 included include VBN cord-023095-4dannjjm 5309 16 in in IN cord-023095-4dannjjm 5309 17 this this DT cord-023095-4dannjjm 5309 18 study study NN cord-023095-4dannjjm 5309 19 . . . cord-023095-4dannjjm 5310 1 Dogs dog NNS cord-023095-4dannjjm 5310 2 were be VBD cord-023095-4dannjjm 5310 3 assigned assign VBN cord-023095-4dannjjm 5310 4 to to IN cord-023095-4dannjjm 5310 5 the the DT cord-023095-4dannjjm 5310 6 following following JJ cord-023095-4dannjjm 5310 7 3 3 CD cord-023095-4dannjjm 5310 8 age age NN cord-023095-4dannjjm 5310 9 groups group NNS cord-023095-4dannjjm 5310 10 : : : cord-023095-4dannjjm 5311 1 o o NN cord-023095-4dannjjm 5311 2 1 1 CD cord-023095-4dannjjm 5311 3 year year NN cord-023095-4dannjjm 5311 4 ( ( -LRB- cord-023095-4dannjjm 5311 5 group group NN cord-023095-4dannjjm 5311 6 1 1 CD cord-023095-4dannjjm 5311 7 ) ) -RRB- cord-023095-4dannjjm 5311 8 ; ; : cord-023095-4dannjjm 5311 9 3 3 CD cord-023095-4dannjjm 5311 10 - - SYM cord-023095-4dannjjm 5311 11 6 6 CD cord-023095-4dannjjm 5311 12 years year NNS cord-023095-4dannjjm 5311 13 ( ( -LRB- cord-023095-4dannjjm 5311 14 group group NN cord-023095-4dannjjm 5311 15 2 2 CD cord-023095-4dannjjm 5311 16 ) ) -RRB- cord-023095-4dannjjm 5311 17 ; ; : cord-023095-4dannjjm 5311 18 and and CC cord-023095-4dannjjm 5311 19 o o NN cord-023095-4dannjjm 5311 20 10 10 CD cord-023095-4dannjjm 5311 21 years year NNS cord-023095-4dannjjm 5311 22 ( ( -LRB- cord-023095-4dannjjm 5311 23 group group NN cord-023095-4dannjjm 5311 24 3 3 CD cord-023095-4dannjjm 5311 25 ) ) -RRB- cord-023095-4dannjjm 5311 26 . . . cord-023095-4dannjjm 5312 1 DCE DCE NNP cord-023095-4dannjjm 5312 2 - - HYPH cord-023095-4dannjjm 5312 3 CT CT NNP cord-023095-4dannjjm 5312 4 scans scan NNS cord-023095-4dannjjm 5312 5 were be VBD cord-023095-4dannjjm 5312 6 performed perform VBN cord-023095-4dannjjm 5312 7 at at IN cord-023095-4dannjjm 5312 8 the the DT cord-023095-4dannjjm 5312 9 level level NN cord-023095-4dannjjm 5312 10 of of IN cord-023095-4dannjjm 5312 11 the the DT cord-023095-4dannjjm 5312 12 third third JJ cord-023095-4dannjjm 5312 13 ventricle ventricle NN cord-023095-4dannjjm 5312 14 and and CC cord-023095-4dannjjm 5312 15 mesencephalic mesencephalic NNP cord-023095-4dannjjm 5312 16 aqueduct aqueduct NNP cord-023095-4dannjjm 5312 17 . . . cord-023095-4dannjjm 5313 1 CBF CBF NNP cord-023095-4dannjjm 5313 2 in in IN cord-023095-4dannjjm 5313 3 the the DT cord-023095-4dannjjm 5313 4 gray gray JJ cord-023095-4dannjjm 5313 5 and and CC cord-023095-4dannjjm 5313 6 white white JJ cord-023095-4dannjjm 5313 7 matter matter NN cord-023095-4dannjjm 5313 8 was be VBD cord-023095-4dannjjm 5313 9 calculated calculate VBN cord-023095-4dannjjm 5313 10 using use VBG cord-023095-4dannjjm 5313 11 STROKETOOL STROKETOOL NNP cord-023095-4dannjjm 5313 12 - - HYPH cord-023095-4dannjjm 5313 13 CT CT NNP cord-023095-4dannjjm 5313 14 s s NNP cord-023095-4dannjjm 5313 15 software software NN cord-023095-4dannjjm 5313 16 . . . cord-023095-4dannjjm 5314 1 The the DT cord-023095-4dannjjm 5314 2 overall overall JJ cord-023095-4dannjjm 5314 3 mean mean JJ cord-023095-4dannjjm 5314 4 AE AE NNP cord-023095-4dannjjm 5314 5 standard standard JJ cord-023095-4dannjjm 5314 6 deviation deviation NN cord-023095-4dannjjm 5314 7 quantitative quantitative JJ cord-023095-4dannjjm 5314 8 estimate estimate NN cord-023095-4dannjjm 5314 9 for for IN cord-023095-4dannjjm 5314 10 regional regional JJ cord-023095-4dannjjm 5314 11 CBF cbf NN cord-023095-4dannjjm 5314 12 in in IN cord-023095-4dannjjm 5314 13 clinically clinically RB cord-023095-4dannjjm 5314 14 normal normal JJ cord-023095-4dannjjm 5314 15 dogs dog NNS cord-023095-4dannjjm 5314 16 was be VBD cord-023095-4dannjjm 5314 17 67.8 67.8 CD cord-023095-4dannjjm 5314 18 AE AE NNP cord-023095-4dannjjm 5314 19 12.9 12.9 CD cord-023095-4dannjjm 5314 20 ml ml NNS cord-023095-4dannjjm 5314 21 / / SYM cord-023095-4dannjjm 5314 22 min/ min/ NNP cord-023095-4dannjjm 5314 23 100 100 CD cord-023095-4dannjjm 5314 24 g g NN cord-023095-4dannjjm 5314 25 , , , cord-023095-4dannjjm 5314 26 44.7 44.7 CD cord-023095-4dannjjm 5314 27 AE AE NNP cord-023095-4dannjjm 5314 28 4.1 4.1 CD cord-023095-4dannjjm 5314 29 ml ml NNS cord-023095-4dannjjm 5314 30 / / SYM cord-023095-4dannjjm 5314 31 min/100 min/100 NNS cord-023095-4dannjjm 5314 32 g g NN cord-023095-4dannjjm 5314 33 , , , cord-023095-4dannjjm 5314 34 and and CC cord-023095-4dannjjm 5314 35 31.0 31.0 CD cord-023095-4dannjjm 5314 36 AE AE NNP cord-023095-4dannjjm 5314 37 3.4 3.4 CD cord-023095-4dannjjm 5314 38 ml ml NNS cord-023095-4dannjjm 5314 39 / / SYM cord-023095-4dannjjm 5314 40 min/100 min/100 NNS cord-023095-4dannjjm 5314 41 g g NN cord-023095-4dannjjm 5314 42 in in IN cord-023095-4dannjjm 5314 43 groups group NNS cord-023095-4dannjjm 5314 44 1 1 CD cord-023095-4dannjjm 5314 45 , , , cord-023095-4dannjjm 5314 46 2 2 CD cord-023095-4dannjjm 5314 47 , , , cord-023095-4dannjjm 5314 48 and and CC cord-023095-4dannjjm 5314 49 3 3 CD cord-023095-4dannjjm 5314 50 , , , cord-023095-4dannjjm 5314 51 respectively respectively RB cord-023095-4dannjjm 5314 52 . . . cord-023095-4dannjjm 5315 1 There there EX cord-023095-4dannjjm 5315 2 was be VBD cord-023095-4dannjjm 5315 3 no no DT cord-023095-4dannjjm 5315 4 significant significant JJ cord-023095-4dannjjm 5315 5 regional regional JJ cord-023095-4dannjjm 5315 6 CBF CBF NNP cord-023095-4dannjjm 5315 7 difference difference NN cord-023095-4dannjjm 5315 8 between between IN cord-023095-4dannjjm 5315 9 the the DT cord-023095-4dannjjm 5315 10 right right NN cord-023095-4dannjjm 5315 11 and and CC cord-023095-4dannjjm 5315 12 left left JJ cord-023095-4dannjjm 5315 13 sides side NNS cord-023095-4dannjjm 5315 14 of of IN cord-023095-4dannjjm 5315 15 the the DT cord-023095-4dannjjm 5315 16 brain brain NN cord-023095-4dannjjm 5315 17 in in IN cord-023095-4dannjjm 5315 18 each each DT cord-023095-4dannjjm 5315 19 group group NN cord-023095-4dannjjm 5315 20 . . . cord-023095-4dannjjm 5316 1 Also also RB cord-023095-4dannjjm 5316 2 , , , cord-023095-4dannjjm 5316 3 a a DT cord-023095-4dannjjm 5316 4 statistically statistically RB cord-023095-4dannjjm 5316 5 significant significant JJ cord-023095-4dannjjm 5316 6 difference difference NN cord-023095-4dannjjm 5316 7 in in IN cord-023095-4dannjjm 5316 8 the the DT cord-023095-4dannjjm 5316 9 regional regional JJ cord-023095-4dannjjm 5316 10 CBF CBF NNP cord-023095-4dannjjm 5316 11 was be VBD cord-023095-4dannjjm 5316 12 observed observe VBN cord-023095-4dannjjm 5316 13 between between IN cord-023095-4dannjjm 5316 14 groups group NNS cord-023095-4dannjjm 5316 15 2 2 CD cord-023095-4dannjjm 5316 16 and and CC cord-023095-4dannjjm 5316 17 3 3 CD cord-023095-4dannjjm 5316 18 ( ( -LRB- cord-023095-4dannjjm 5316 19 P p NN cord-023095-4dannjjm 5316 20 o o NN cord-023095-4dannjjm 5316 21 0.001 0.001 CD cord-023095-4dannjjm 5316 22 ) ) -RRB- cord-023095-4dannjjm 5316 23 . . . cord-023095-4dannjjm 5317 1 Thus thus RB cord-023095-4dannjjm 5317 2 , , , cord-023095-4dannjjm 5317 3 aging aging NN cord-023095-4dannjjm 5317 4 affects affect VBZ cord-023095-4dannjjm 5317 5 the the DT cord-023095-4dannjjm 5317 6 regional regional JJ cord-023095-4dannjjm 5317 7 CBF cbf NN cord-023095-4dannjjm 5317 8 in in IN cord-023095-4dannjjm 5317 9 normal normal JJ cord-023095-4dannjjm 5317 10 dogs dog NNS cord-023095-4dannjjm 5317 11 and and CC cord-023095-4dannjjm 5317 12 the the DT cord-023095-4dannjjm 5317 13 values value NNS cord-023095-4dannjjm 5317 14 should should MD cord-023095-4dannjjm 5317 15 be be VB cord-023095-4dannjjm 5317 16 considered consider VBN cord-023095-4dannjjm 5317 17 assessing assess VBG cord-023095-4dannjjm 5317 18 the the DT cord-023095-4dannjjm 5317 19 results result NNS cord-023095-4dannjjm 5317 20 of of IN cord-023095-4dannjjm 5317 21 DCE DCE NNP cord-023095-4dannjjm 5317 22 - - HYPH cord-023095-4dannjjm 5317 23 CT CT NNP cord-023095-4dannjjm 5317 24 . . . cord-023095-4dannjjm 5318 1 According accord VBG cord-023095-4dannjjm 5318 2 to to IN cord-023095-4dannjjm 5318 3 several several JJ cord-023095-4dannjjm 5318 4 clinical clinical JJ cord-023095-4dannjjm 5318 5 behavior behavior NN cord-023095-4dannjjm 5318 6 guidelines guideline NNS cord-023095-4dannjjm 5318 7 , , , cord-023095-4dannjjm 5318 8 ' ' '' cord-023095-4dannjjm 5318 9 ' ' `` cord-023095-4dannjjm 5318 10 toileting toileting NN cord-023095-4dannjjm 5318 11 ' ' '' cord-023095-4dannjjm 5318 12 ' ' '' cord-023095-4dannjjm 5318 13 type type NN cord-023095-4dannjjm 5318 14 inappropriate inappropriate JJ cord-023095-4dannjjm 5318 15 urination urination NN cord-023095-4dannjjm 5318 16 ( ( -LRB- cord-023095-4dannjjm 5318 17 i.e. i.e. FW cord-023095-4dannjjm 5318 18 large large JJ cord-023095-4dannjjm 5318 19 amounts amount NNS cord-023095-4dannjjm 5318 20 of of IN cord-023095-4dannjjm 5318 21 urine urine NN cord-023095-4dannjjm 5318 22 deposited deposit VBN cord-023095-4dannjjm 5318 23 in in IN cord-023095-4dannjjm 5318 24 horizontal horizontal JJ cord-023095-4dannjjm 5318 25 surfaces surface NNS cord-023095-4dannjjm 5318 26 ) ) -RRB- cord-023095-4dannjjm 5318 27 can can MD cord-023095-4dannjjm 5318 28 arise arise VB cord-023095-4dannjjm 5318 29 in in IN cord-023095-4dannjjm 5318 30 cats cat NNS cord-023095-4dannjjm 5318 31 suffering suffer VBG cord-023095-4dannjjm 5318 32 from from IN cord-023095-4dannjjm 5318 33 a a DT cord-023095-4dannjjm 5318 34 medical medical JJ cord-023095-4dannjjm 5318 35 problem problem NN cord-023095-4dannjjm 5318 36 ( ( -LRB- cord-023095-4dannjjm 5318 37 typically typically RB cord-023095-4dannjjm 5318 38 lower low JJR cord-023095-4dannjjm 5318 39 urinary urinary JJ cord-023095-4dannjjm 5318 40 tract tract NN cord-023095-4dannjjm 5318 41 disease disease NN cord-023095-4dannjjm 5318 42 ) ) -RRB- cord-023095-4dannjjm 5318 43 . . . cord-023095-4dannjjm 5319 1 By by IN cord-023095-4dannjjm 5319 2 contrast contrast NN cord-023095-4dannjjm 5319 3 , , , cord-023095-4dannjjm 5319 4 ' ' '' cord-023095-4dannjjm 5319 5 ' ' `` cord-023095-4dannjjm 5319 6 spraying spray VBG cord-023095-4dannjjm 5319 7 ' ' '' cord-023095-4dannjjm 5319 8 ' ' `` cord-023095-4dannjjm 5319 9 type type NN cord-023095-4dannjjm 5319 10 behaviour behaviour NN cord-023095-4dannjjm 5319 11 ( ( -LRB- cord-023095-4dannjjm 5319 12 i.e. i.e. FW cord-023095-4dannjjm 5319 13 possibly possibly RB cord-023095-4dannjjm 5319 14 smaller small JJR cord-023095-4dannjjm 5319 15 amounts amount NNS cord-023095-4dannjjm 5319 16 of of IN cord-023095-4dannjjm 5319 17 urine urine NN cord-023095-4dannjjm 5319 18 deposited deposit VBN cord-023095-4dannjjm 5319 19 on on IN cord-023095-4dannjjm 5319 20 vertical vertical JJ cord-023095-4dannjjm 5319 21 areas area NNS cord-023095-4dannjjm 5319 22 ) ) -RRB- cord-023095-4dannjjm 5319 23 is be VBZ cord-023095-4dannjjm 5319 24 more more RBR cord-023095-4dannjjm 5319 25 typically typically RB cord-023095-4dannjjm 5319 26 associated associate VBN cord-023095-4dannjjm 5319 27 with with IN cord-023095-4dannjjm 5319 28 anxiety anxiety NN cord-023095-4dannjjm 5319 29 brought bring VBN cord-023095-4dannjjm 5319 30 about about RP cord-023095-4dannjjm 5319 31 by by IN cord-023095-4dannjjm 5319 32 a a DT cord-023095-4dannjjm 5319 33 threat threat NN cord-023095-4dannjjm 5319 34 to to IN cord-023095-4dannjjm 5319 35 local local JJ cord-023095-4dannjjm 5319 36 resources resource NNS cord-023095-4dannjjm 5319 37 , , , cord-023095-4dannjjm 5319 38 arising arise VBG cord-023095-4dannjjm 5319 39 from from IN cord-023095-4dannjjm 5319 40 either either CC cord-023095-4dannjjm 5319 41 a a DT cord-023095-4dannjjm 5319 42 change change NN cord-023095-4dannjjm 5319 43 in in IN cord-023095-4dannjjm 5319 44 the the DT cord-023095-4dannjjm 5319 45 physical physical JJ cord-023095-4dannjjm 5319 46 environment environment NN cord-023095-4dannjjm 5319 47 or or CC cord-023095-4dannjjm 5319 48 threat threat NN cord-023095-4dannjjm 5319 49 to to IN cord-023095-4dannjjm 5319 50 these these DT cord-023095-4dannjjm 5319 51 resources resource NNS cord-023095-4dannjjm 5319 52 from from IN cord-023095-4dannjjm 5319 53 another another DT cord-023095-4dannjjm 5319 54 cat cat NN cord-023095-4dannjjm 5319 55 . . . cord-023095-4dannjjm 5320 1 However however RB cord-023095-4dannjjm 5320 2 , , , cord-023095-4dannjjm 5320 3 there there EX cord-023095-4dannjjm 5320 4 is be VBZ cord-023095-4dannjjm 5320 5 some some DT cord-023095-4dannjjm 5320 6 evidence evidence NN cord-023095-4dannjjm 5320 7 that that IN cord-023095-4dannjjm 5320 8 ' ' '' cord-023095-4dannjjm 5320 9 ' ' `` cord-023095-4dannjjm 5320 10 sprayers sprayer NNS cord-023095-4dannjjm 5320 11 ' ' '' cord-023095-4dannjjm 5320 12 ' ' '' cord-023095-4dannjjm 5320 13 may may MD cord-023095-4dannjjm 5320 14 also also RB cord-023095-4dannjjm 5320 15 be be VB cord-023095-4dannjjm 5320 16 presented present VBN cord-023095-4dannjjm 5320 17 with with IN cord-023095-4dannjjm 5320 18 a a DT cord-023095-4dannjjm 5320 19 medical medical JJ cord-023095-4dannjjm 5320 20 problem problem NN cord-023095-4dannjjm 5320 21 , , , cord-023095-4dannjjm 5320 22 which which WDT cord-023095-4dannjjm 5320 23 might may MD cord-023095-4dannjjm 5320 24 be be VB cord-023095-4dannjjm 5320 25 linked link VBN cord-023095-4dannjjm 5320 26 to to IN cord-023095-4dannjjm 5320 27 the the DT cord-023095-4dannjjm 5320 28 disease disease NN cord-023095-4dannjjm 5321 1 ( ( -LRB- cord-023095-4dannjjm 5321 2 e.g. e.g. DT cord-023095-4dannjjm 5321 3 painful painful JJ cord-023095-4dannjjm 5321 4 voiding voiding NN cord-023095-4dannjjm 5321 5 associated associate VBN cord-023095-4dannjjm 5321 6 with with IN cord-023095-4dannjjm 5321 7 crystalluria crystalluria NNP cord-023095-4dannjjm 5321 8 may may MD cord-023095-4dannjjm 5321 9 lead lead VB cord-023095-4dannjjm 5321 10 to to IN cord-023095-4dannjjm 5321 11 a a DT cord-023095-4dannjjm 5321 12 standing standing JJ cord-023095-4dannjjm 5321 13 posture posture NN cord-023095-4dannjjm 5321 14 being be VBG cord-023095-4dannjjm 5321 15 adopted adopt VBN cord-023095-4dannjjm 5321 16 and and CC cord-023095-4dannjjm 5321 17 small small JJ cord-023095-4dannjjm 5321 18 amounts amount NNS cord-023095-4dannjjm 5321 19 eliminated eliminate VBN cord-023095-4dannjjm 5321 20 at at IN cord-023095-4dannjjm 5321 21 a a DT cord-023095-4dannjjm 5321 22 given give VBN cord-023095-4dannjjm 5321 23 time time NN cord-023095-4dannjjm 5321 24 ) ) -RRB- cord-023095-4dannjjm 5321 25 . . . cord-023095-4dannjjm 5322 1 This this DT cord-023095-4dannjjm 5322 2 might may MD cord-023095-4dannjjm 5322 3 be be VB cord-023095-4dannjjm 5322 4 associated associate VBN cord-023095-4dannjjm 5322 5 with with IN cord-023095-4dannjjm 5322 6 an an DT cord-023095-4dannjjm 5322 7 apprehensive apprehensive JJ cord-023095-4dannjjm 5322 8 state state NN cord-023095-4dannjjm 5322 9 or or CC cord-023095-4dannjjm 5322 10 simply simply RB cord-023095-4dannjjm 5322 11 a a DT cord-023095-4dannjjm 5322 12 co co JJ cord-023095-4dannjjm 5322 13 - - JJ cord-023095-4dannjjm 5322 14 morbid morbid JJ cord-023095-4dannjjm 5322 15 state state NN cord-023095-4dannjjm 5322 16 . . . cord-023095-4dannjjm 5323 1 As as IN cord-023095-4dannjjm 5323 2 part part NN cord-023095-4dannjjm 5323 3 of of IN cord-023095-4dannjjm 5323 4 a a DT cord-023095-4dannjjm 5323 5 larger large JJR cord-023095-4dannjjm 5323 6 research research NN cord-023095-4dannjjm 5323 7 project project NN cord-023095-4dannjjm 5323 8 aimed aim VBN cord-023095-4dannjjm 5323 9 at at IN cord-023095-4dannjjm 5323 10 investigating investigate VBG cord-023095-4dannjjm 5323 11 behavioral behavioral JJ cord-023095-4dannjjm 5323 12 and and CC cord-023095-4dannjjm 5323 13 physical physical JJ cord-023095-4dannjjm 5323 14 aspects aspect NNS cord-023095-4dannjjm 5323 15 of of IN cord-023095-4dannjjm 5323 16 cats cat NNS cord-023095-4dannjjm 5323 17 presented present VBN cord-023095-4dannjjm 5323 18 with with IN cord-023095-4dannjjm 5323 19 inappropriate inappropriate JJ cord-023095-4dannjjm 5323 20 urination urination NN cord-023095-4dannjjm 5323 21 , , , cord-023095-4dannjjm 5323 22 owners owner NNS cord-023095-4dannjjm 5323 23 of of IN cord-023095-4dannjjm 5323 24 14 14 CD cord-023095-4dannjjm 5323 25 ' ' POS cord-023095-4dannjjm 5323 26 ' ' `` cord-023095-4dannjjm 5323 27 spraying spraying NN cord-023095-4dannjjm 5323 28 ' ' '' cord-023095-4dannjjm 5323 29 ' ' '' cord-023095-4dannjjm 5323 30 and and CC cord-023095-4dannjjm 5323 31 18 18 CD cord-023095-4dannjjm 5323 32 ' ' POS cord-023095-4dannjjm 5323 33 ' ' `` cord-023095-4dannjjm 5323 34 toileting toileting NN cord-023095-4dannjjm 5323 35 ' ' '' cord-023095-4dannjjm 5323 36 ' ' '' cord-023095-4dannjjm 5323 37 cats cat NNS cord-023095-4dannjjm 5323 38 with with IN cord-023095-4dannjjm 5323 39 appropriate appropriate JJ cord-023095-4dannjjm 5323 40 control control NN cord-023095-4dannjjm 5323 41 subjects subject NNS cord-023095-4dannjjm 5323 42 from from IN cord-023095-4dannjjm 5323 43 the the DT cord-023095-4dannjjm 5323 44 same same JJ cord-023095-4dannjjm 5323 45 households household NNS cord-023095-4dannjjm 5323 46 were be VBD cord-023095-4dannjjm 5323 47 recruited recruit VBN cord-023095-4dannjjm 5323 48 throughout throughout IN cord-023095-4dannjjm 5323 49 local local JJ cord-023095-4dannjjm 5323 50 media medium NNS cord-023095-4dannjjm 5323 51 coverage coverage NN cord-023095-4dannjjm 5323 52 and and CC cord-023095-4dannjjm 5323 53 the the DT cord-023095-4dannjjm 5323 54 internet internet NN cord-023095-4dannjjm 5323 55 . . . cord-023095-4dannjjm 5324 1 The the DT cord-023095-4dannjjm 5324 2 case case NN cord-023095-4dannjjm 5324 3 - - HYPH cord-023095-4dannjjm 5324 4 control control NN cord-023095-4dannjjm 5324 5 dyads dyad NNS cord-023095-4dannjjm 5324 6 were be VBD cord-023095-4dannjjm 5324 7 brought bring VBN cord-023095-4dannjjm 5324 8 by by IN cord-023095-4dannjjm 5324 9 the the DT cord-023095-4dannjjm 5324 10 owners owner NNS cord-023095-4dannjjm 5324 11 to to IN cord-023095-4dannjjm 5324 12 the the DT cord-023095-4dannjjm 5324 13 veterinary veterinary JJ cord-023095-4dannjjm 5324 14 hospital hospital NN cord-023095-4dannjjm 5324 15 of of IN cord-023095-4dannjjm 5324 16 the the DT cord-023095-4dannjjm 5324 17 University University NNP cord-023095-4dannjjm 5324 18 of of IN cord-023095-4dannjjm 5324 19 Sa˜o Sa˜o NNP cord-023095-4dannjjm 5324 20 Paulo Paulo NNP cord-023095-4dannjjm 5324 21 , , , cord-023095-4dannjjm 5324 22 at at IN cord-023095-4dannjjm 5324 23 the the DT cord-023095-4dannjjm 5324 24 same same JJ cord-023095-4dannjjm 5324 25 time time NN cord-023095-4dannjjm 5324 26 , , , cord-023095-4dannjjm 5324 27 for for IN cord-023095-4dannjjm 5324 28 a a DT cord-023095-4dannjjm 5324 29 medical medical JJ cord-023095-4dannjjm 5324 30 work work NN cord-023095-4dannjjm 5324 31 - - HYPH cord-023095-4dannjjm 5324 32 up up NN cord-023095-4dannjjm 5324 33 ( ( -LRB- cord-023095-4dannjjm 5324 34 i.e. i.e. FW cord-023095-4dannjjm 5324 35 physical physical JJ cord-023095-4dannjjm 5324 36 examination examination NN cord-023095-4dannjjm 5324 37 , , , cord-023095-4dannjjm 5324 38 complete complete JJ cord-023095-4dannjjm 5324 39 blood blood NN cord-023095-4dannjjm 5324 40 count count NN cord-023095-4dannjjm 5324 41 , , , cord-023095-4dannjjm 5324 42 biochemical biochemical JJ cord-023095-4dannjjm 5324 43 profile profile NN cord-023095-4dannjjm 5324 44 , , , cord-023095-4dannjjm 5324 45 urinalysis urinalysis NN cord-023095-4dannjjm 5324 46 , , , cord-023095-4dannjjm 5324 47 urine urine NN cord-023095-4dannjjm 5324 48 culture culture NN cord-023095-4dannjjm 5324 49 and and CC cord-023095-4dannjjm 5324 50 abdominal abdominal JJ cord-023095-4dannjjm 5324 51 ultrasound ultrasound NN cord-023095-4dannjjm 5324 52 ) ) -RRB- cord-023095-4dannjjm 5324 53 . . . cord-023095-4dannjjm 5325 1 No no DT cord-023095-4dannjjm 5325 2 significant significant JJ cord-023095-4dannjjm 5325 3 differences difference NNS cord-023095-4dannjjm 5325 4 between between IN cord-023095-4dannjjm 5325 5 the the DT cord-023095-4dannjjm 5325 6 ' ' `` cord-023095-4dannjjm 5325 7 ' ' `` cord-023095-4dannjjm 5325 8 sprayers sprayer NNS cord-023095-4dannjjm 5325 9 ' ' '' cord-023095-4dannjjm 5325 10 ' ' '' cord-023095-4dannjjm 5325 11 and and CC cord-023095-4dannjjm 5325 12 ' ' `` cord-023095-4dannjjm 5325 13 ' ' `` cord-023095-4dannjjm 5325 14 toileters toileter NNS cord-023095-4dannjjm 5325 15 ' ' '' cord-023095-4dannjjm 5325 16 ' ' '' cord-023095-4dannjjm 5325 17 regarding regard VBG cord-023095-4dannjjm 5325 18 the the DT cord-023095-4dannjjm 5325 19 occurrence occurrence NN cord-023095-4dannjjm 5325 20 of of IN cord-023095-4dannjjm 5325 21 medical medical JJ cord-023095-4dannjjm 5325 22 problems problem NNS cord-023095-4dannjjm 5325 23 were be VBD cord-023095-4dannjjm 5325 24 found find VBN cord-023095-4dannjjm 5325 25 . . . cord-023095-4dannjjm 5326 1 Both both DT cord-023095-4dannjjm 5326 2 groups group NNS cord-023095-4dannjjm 5326 3 had have VBD cord-023095-4dannjjm 5326 4 a a DT cord-023095-4dannjjm 5326 5 similar similar JJ cord-023095-4dannjjm 5326 6 proportion proportion NN cord-023095-4dannjjm 5326 7 of of IN cord-023095-4dannjjm 5326 8 cats cat NNS cord-023095-4dannjjm 5326 9 affected affect VBN cord-023095-4dannjjm 5326 10 by by IN cord-023095-4dannjjm 5326 11 medical medical JJ cord-023095-4dannjjm 5326 12 illnesses illness NNS cord-023095-4dannjjm 5326 13 ( ( -LRB- cord-023095-4dannjjm 5326 14 sprayers sprayer NNS cord-023095-4dannjjm 5326 15 : : : cord-023095-4dannjjm 5326 16 35.7 35.7 CD cord-023095-4dannjjm 5326 17 % % NN cord-023095-4dannjjm 5326 18 , , , cord-023095-4dannjjm 5326 19 toileters toileter NNS cord-023095-4dannjjm 5326 20 : : : cord-023095-4dannjjm 5326 21 44.4 44.4 CD cord-023095-4dannjjm 5326 22 % % NN cord-023095-4dannjjm 5326 23 ; ; : cord-023095-4dannjjm 5326 24 Chi Chi NNP cord-023095-4dannjjm 5326 25 2 2 CD cord-023095-4dannjjm 5326 26 , , , cord-023095-4dannjjm 5326 27 p p NN cord-023095-4dannjjm 5326 28 5 5 CD cord-023095-4dannjjm 5326 29 0.618 0.618 CD cord-023095-4dannjjm 5326 30 ) ) -RRB- cord-023095-4dannjjm 5326 31 , , , cord-023095-4dannjjm 5326 32 directly directly RB cord-023095-4dannjjm 5326 33 or or CC cord-023095-4dannjjm 5326 34 indirectly indirectly RB cord-023095-4dannjjm 5326 35 relating relate VBG cord-023095-4dannjjm 5326 36 to to IN cord-023095-4dannjjm 5326 37 the the DT cord-023095-4dannjjm 5326 38 urinary urinary JJ cord-023095-4dannjjm 5326 39 system system NN cord-023095-4dannjjm 5326 40 ( ( -LRB- cord-023095-4dannjjm 5326 41 e.g. e.g. IN cord-023095-4dannjjm 5326 42 diabetes diabetes NN cord-023095-4dannjjm 5326 43 , , , cord-023095-4dannjjm 5326 44 chronic chronic JJ cord-023095-4dannjjm 5326 45 kidney kidney NN cord-023095-4dannjjm 5326 46 disease disease NN cord-023095-4dannjjm 5326 47 ) ) -RRB- cord-023095-4dannjjm 5326 48 . . . cord-023095-4dannjjm 5327 1 In in IN cord-023095-4dannjjm 5327 2 both both DT cord-023095-4dannjjm 5327 3 groups group NNS cord-023095-4dannjjm 5327 4 , , , cord-023095-4dannjjm 5327 5 control control NN cord-023095-4dannjjm 5327 6 cats cat NNS cord-023095-4dannjjm 5327 7 also also RB cord-023095-4dannjjm 5327 8 had have VBD cord-023095-4dannjjm 5327 9 a a DT cord-023095-4dannjjm 5327 10 relatively relatively RB cord-023095-4dannjjm 5327 11 high high JJ cord-023095-4dannjjm 5327 12 occurrence occurrence NN cord-023095-4dannjjm 5327 13 of of IN cord-023095-4dannjjm 5327 14 medical medical JJ cord-023095-4dannjjm 5327 15 concerns concern NNS cord-023095-4dannjjm 5327 16 ( ( -LRB- cord-023095-4dannjjm 5327 17 21.4 21.4 CD cord-023095-4dannjjm 5327 18 % % NN cord-023095-4dannjjm 5327 19 and and CC cord-023095-4dannjjm 5327 20 27.8 27.8 CD cord-023095-4dannjjm 5327 21 % % NN cord-023095-4dannjjm 5327 22 , , , cord-023095-4dannjjm 5327 23 respectively respectively RB cord-023095-4dannjjm 5327 24 for for IN cord-023095-4dannjjm 5327 25 each each DT cord-023095-4dannjjm 5327 26 control control NN cord-023095-4dannjjm 5327 27 group group NN cord-023095-4dannjjm 5327 28 ) ) -RRB- cord-023095-4dannjjm 5327 29 . . . cord-023095-4dannjjm 5328 1 These these DT cord-023095-4dannjjm 5328 2 results result NNS cord-023095-4dannjjm 5328 3 emphasize emphasize VBP cord-023095-4dannjjm 5328 4 the the DT cord-023095-4dannjjm 5328 5 importance importance NN cord-023095-4dannjjm 5328 6 of of IN cord-023095-4dannjjm 5328 7 careful careful JJ cord-023095-4dannjjm 5328 8 medical medical JJ cord-023095-4dannjjm 5328 9 evaluation evaluation NN cord-023095-4dannjjm 5328 10 of of IN cord-023095-4dannjjm 5328 11 cats cat NNS cord-023095-4dannjjm 5328 12 presented present VBN cord-023095-4dannjjm 5328 13 for for IN cord-023095-4dannjjm 5328 14 a a DT cord-023095-4dannjjm 5328 15 urinary urinary JJ cord-023095-4dannjjm 5328 16 housesoiling housesoiling NN cord-023095-4dannjjm 5328 17 problem problem NN cord-023095-4dannjjm 5328 18 . . . cord-023095-4dannjjm 5329 1 The the DT cord-023095-4dannjjm 5329 2 relatively relatively RB cord-023095-4dannjjm 5329 3 high high JJ cord-023095-4dannjjm 5329 4 prevalence prevalence NN cord-023095-4dannjjm 5329 5 of of IN cord-023095-4dannjjm 5329 6 medical medical JJ cord-023095-4dannjjm 5329 7 concerns concern NNS cord-023095-4dannjjm 5329 8 among among IN cord-023095-4dannjjm 5329 9 apparently apparently RB cord-023095-4dannjjm 5329 10 healthy healthy JJ cord-023095-4dannjjm 5329 11 cats cat NNS cord-023095-4dannjjm 5329 12 in in IN cord-023095-4dannjjm 5329 13 multi multi JJ cord-023095-4dannjjm 5329 14 - - JJ cord-023095-4dannjjm 5329 15 cat cat JJ cord-023095-4dannjjm 5329 16 households household NNS cord-023095-4dannjjm 5329 17 may may MD cord-023095-4dannjjm 5329 18 have have VB cord-023095-4dannjjm 5329 19 arisen arise VBN cord-023095-4dannjjm 5329 20 , , , cord-023095-4dannjjm 5329 21 at at IN cord-023095-4dannjjm 5329 22 least least JJS cord-023095-4dannjjm 5329 23 in in IN cord-023095-4dannjjm 5329 24 part part NN cord-023095-4dannjjm 5329 25 , , , cord-023095-4dannjjm 5329 26 as as IN cord-023095-4dannjjm 5329 27 a a DT cord-023095-4dannjjm 5329 28 result result NN cord-023095-4dannjjm 5329 29 of of IN cord-023095-4dannjjm 5329 30 an an DT cord-023095-4dannjjm 5329 31 inability inability NN cord-023095-4dannjjm 5329 32 / / SYM cord-023095-4dannjjm 5329 33 failure failure NN cord-023095-4dannjjm 5329 34 of of IN cord-023095-4dannjjm 5329 35 owners owner NNS cord-023095-4dannjjm 5329 36 to to TO cord-023095-4dannjjm 5329 37 monitor monitor VB cord-023095-4dannjjm 5329 38 individuals individual NNS cord-023095-4dannjjm 5329 39 , , , cord-023095-4dannjjm 5329 40 thus thus RB cord-023095-4dannjjm 5329 41 allowing allow VBG cord-023095-4dannjjm 5329 42 some some DT cord-023095-4dannjjm 5329 43 early early JJ cord-023095-4dannjjm 5329 44 signs sign NNS cord-023095-4dannjjm 5329 45 to to TO cord-023095-4dannjjm 5329 46 pass pass VB cord-023095-4dannjjm 5329 47 unnoticed unnoticed JJ cord-023095-4dannjjm 5329 48 . . . cord-023095-4dannjjm 5330 1 The the DT cord-023095-4dannjjm 5330 2 way way NN cord-023095-4dannjjm 5330 3 in in IN cord-023095-4dannjjm 5330 4 which which WDT cord-023095-4dannjjm 5330 5 medical medical JJ cord-023095-4dannjjm 5330 6 and and CC cord-023095-4dannjjm 5330 7 behavioral behavioral JJ cord-023095-4dannjjm 5330 8 elements element NNS cord-023095-4dannjjm 5330 9 are be VBP cord-023095-4dannjjm 5330 10 linked link VBN cord-023095-4dannjjm 5330 11 ( ( -LRB- cord-023095-4dannjjm 5330 12 if if IN cord-023095-4dannjjm 5330 13 at at RB cord-023095-4dannjjm 5330 14 all all RB cord-023095-4dannjjm 5330 15 ) ) -RRB- cord-023095-4dannjjm 5330 16 remain remain VBP cord-023095-4dannjjm 5330 17 unknown unknown JJ cord-023095-4dannjjm 5330 18 but but CC cord-023095-4dannjjm 5330 19 deserve deserve VBP cord-023095-4dannjjm 5330 20 further further JJ cord-023095-4dannjjm 5330 21 investigation investigation NN cord-023095-4dannjjm 5330 22 . . . cord-023095-4dannjjm 5331 1 Considered consider VBN cord-023095-4dannjjm 5331 2 as as IN cord-023095-4dannjjm 5331 3 a a DT cord-023095-4dannjjm 5331 4 semi semi JJ cord-023095-4dannjjm 5331 5 - - JJ cord-023095-4dannjjm 5331 6 social social JJ cord-023095-4dannjjm 5331 7 species specie NNS cord-023095-4dannjjm 5331 8 , , , cord-023095-4dannjjm 5331 9 domestic domestic JJ cord-023095-4dannjjm 5331 10 cats cat NNS cord-023095-4dannjjm 5331 11 appear appear VBP cord-023095-4dannjjm 5331 12 to to TO cord-023095-4dannjjm 5331 13 be be VB cord-023095-4dannjjm 5331 14 highly highly RB cord-023095-4dannjjm 5331 15 sensitive sensitive JJ cord-023095-4dannjjm 5331 16 to to IN cord-023095-4dannjjm 5331 17 the the DT cord-023095-4dannjjm 5331 18 effects effect NNS cord-023095-4dannjjm 5331 19 of of IN cord-023095-4dannjjm 5331 20 social social JJ cord-023095-4dannjjm 5331 21 stress stress NN cord-023095-4dannjjm 5331 22 , , , cord-023095-4dannjjm 5331 23 especially especially RB cord-023095-4dannjjm 5331 24 when when WRB cord-023095-4dannjjm 5331 25 living live VBG cord-023095-4dannjjm 5331 26 in in IN cord-023095-4dannjjm 5331 27 high high JJ cord-023095-4dannjjm 5331 28 density density NN cord-023095-4dannjjm 5331 29 populations population NNS cord-023095-4dannjjm 5331 30 . . . cord-023095-4dannjjm 5332 1 Cats cat NNS cord-023095-4dannjjm 5332 2 are be VBP cord-023095-4dannjjm 5332 3 capable capable JJ cord-023095-4dannjjm 5332 4 of of IN cord-023095-4dannjjm 5332 5 adapting adapt VBG cord-023095-4dannjjm 5332 6 to to TO cord-023095-4dannjjm 5332 7 live live VB cord-023095-4dannjjm 5332 8 ingroup ingroup NNP cord-023095-4dannjjm 5332 9 ; ; : cord-023095-4dannjjm 5332 10 nonetheless nonetheless RB cord-023095-4dannjjm 5332 11 , , , cord-023095-4dannjjm 5332 12 they -PRON- PRP cord-023095-4dannjjm 5332 13 do do VBP cord-023095-4dannjjm 5332 14 not not RB cord-023095-4dannjjm 5332 15 appreciate appreciate VB cord-023095-4dannjjm 5332 16 living live VBG cord-023095-4dannjjm 5332 17 in in IN cord-023095-4dannjjm 5332 18 close close JJ cord-023095-4dannjjm 5332 19 proximity proximity NN cord-023095-4dannjjm 5332 20 with with IN cord-023095-4dannjjm 5332 21 others other NNS cord-023095-4dannjjm 5332 22 as as IN cord-023095-4dannjjm 5332 23 result result NN cord-023095-4dannjjm 5332 24 of of IN cord-023095-4dannjjm 5332 25 an an DT cord-023095-4dannjjm 5332 26 environment environment NN cord-023095-4dannjjm 5332 27 lacking lack VBG cord-023095-4dannjjm 5332 28 of of IN cord-023095-4dannjjm 5332 29 great great JJ cord-023095-4dannjjm 5332 30 opportunities opportunity NNS cord-023095-4dannjjm 5332 31 of of IN cord-023095-4dannjjm 5332 32 escaping escape VBG cord-023095-4dannjjm 5332 33 and and CC cord-023095-4dannjjm 5332 34 hiding hide VBG cord-023095-4dannjjm 5332 35 . . . cord-023095-4dannjjm 5333 1 This this DT cord-023095-4dannjjm 5333 2 study study NN cord-023095-4dannjjm 5333 3 aimed aim VBN cord-023095-4dannjjm 5333 4 at at IN cord-023095-4dannjjm 5333 5 testing test VBG cord-023095-4dannjjm 5333 6 the the DT cord-023095-4dannjjm 5333 7 following follow VBG cord-023095-4dannjjm 5333 8 hypotheses hypothesis NNS cord-023095-4dannjjm 5333 9 : : : cord-023095-4dannjjm 5333 10 ( ( -LRB- cord-023095-4dannjjm 5333 11 A a NN cord-023095-4dannjjm 5333 12 ) ) -RRB- cord-023095-4dannjjm 5333 13 owners owner NNS cord-023095-4dannjjm 5333 14 ' ' POS cord-023095-4dannjjm 5333 15 perceived perceive VBN cord-023095-4dannjjm 5333 16 quality quality NN cord-023095-4dannjjm 5333 17 of of IN cord-023095-4dannjjm 5333 18 life life NN cord-023095-4dannjjm 5333 19 affects affect VBZ cord-023095-4dannjjm 5333 20 cats cat NNS cord-023095-4dannjjm 5333 21 ' ' POS cord-023095-4dannjjm 5333 22 global global JJ cord-023095-4dannjjm 5333 23 levels level NNS cord-023095-4dannjjm 5333 24 of of IN cord-023095-4dannjjm 5333 25 stress stress NN cord-023095-4dannjjm 5333 26 ; ; : cord-023095-4dannjjm 5333 27 ( ( -LRB- cord-023095-4dannjjm 5333 28 B b NN cord-023095-4dannjjm 5333 29 ) ) -RRB- cord-023095-4dannjjm 5333 30 cats cat NNS cord-023095-4dannjjm 5333 31 ' ' POS cord-023095-4dannjjm 5333 32 global global JJ cord-023095-4dannjjm 5333 33 levels level NNS cord-023095-4dannjjm 5333 34 of of IN cord-023095-4dannjjm 5333 35 stress stress NN cord-023095-4dannjjm 5333 36 are be VBP cord-023095-4dannjjm 5333 37 influenced influence VBN cord-023095-4dannjjm 5333 38 by by IN cord-023095-4dannjjm 5333 39 cats cat NNS cord-023095-4dannjjm 5333 40 ' ' POS cord-023095-4dannjjm 5333 41 personality personality NN cord-023095-4dannjjm 5333 42 ; ; : cord-023095-4dannjjm 5333 43 ( ( -LRB- cord-023095-4dannjjm 5333 44 C C NNP cord-023095-4dannjjm 5333 45 ) ) -RRB- cord-023095-4dannjjm 5333 46 cats cat NNS cord-023095-4dannjjm 5333 47 ' ' POS cord-023095-4dannjjm 5333 48 living living NN cord-023095-4dannjjm 5333 49 style style NN cord-023095-4dannjjm 5333 50 ( ( -LRB- cord-023095-4dannjjm 5333 51 single single JJ cord-023095-4dannjjm 5333 52 housing housing NN cord-023095-4dannjjm 5333 53 versus versus IN cord-023095-4dannjjm 5333 54 large large JJ cord-023095-4dannjjm 5333 55 group group NN cord-023095-4dannjjm 5333 56 housing housing NN cord-023095-4dannjjm 5333 57 ) ) -RRB- cord-023095-4dannjjm 5333 58 does do VBZ cord-023095-4dannjjm 5333 59 affect affect VB cord-023095-4dannjjm 5333 60 stress stress NN cord-023095-4dannjjm 5333 61 levels level NNS cord-023095-4dannjjm 5333 62 in in IN cord-023095-4dannjjm 5333 63 cats cat NNS cord-023095-4dannjjm 5333 64 . . . cord-023095-4dannjjm 5334 1 To to IN cord-023095-4dannjjm 5334 2 our -PRON- PRP$ cord-023095-4dannjjm 5334 3 knowledge knowledge NN cord-023095-4dannjjm 5334 4 , , , cord-023095-4dannjjm 5334 5 this this DT cord-023095-4dannjjm 5334 6 is be VBZ cord-023095-4dannjjm 5334 7 the the DT cord-023095-4dannjjm 5334 8 first first JJ cord-023095-4dannjjm 5334 9 study study NN cord-023095-4dannjjm 5334 10 investigating investigate VBG cord-023095-4dannjjm 5334 11 stress stress NN cord-023095-4dannjjm 5334 12 levels level NNS cord-023095-4dannjjm 5334 13 of of IN cord-023095-4dannjjm 5334 14 domestic domestic JJ cord-023095-4dannjjm 5334 15 owned own VBN cord-023095-4dannjjm 5334 16 cats cat NNS cord-023095-4dannjjm 5334 17 , , , cord-023095-4dannjjm 5334 18 under under IN cord-023095-4dannjjm 5334 19 natural natural JJ cord-023095-4dannjjm 5334 20 conditions condition NNS cord-023095-4dannjjm 5334 21 , , , cord-023095-4dannjjm 5334 22 throughout throughout IN cord-023095-4dannjjm 5334 23 measurement measurement NN cord-023095-4dannjjm 5334 24 of of IN cord-023095-4dannjjm 5334 25 faecal faecal JJ cord-023095-4dannjjm 5334 26 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 5334 27 metabolites metabolite NNS cord-023095-4dannjjm 5334 28 concentration concentration NN cord-023095-4dannjjm 5334 29 , , , cord-023095-4dannjjm 5334 30 and and CC cord-023095-4dannjjm 5334 31 taking take VBG cord-023095-4dannjjm 5334 32 into into IN cord-023095-4dannjjm 5334 33 consideration consideration NN cord-023095-4dannjjm 5334 34 cat cat NN cord-023095-4dannjjm 5334 35 personality personality NN cord-023095-4dannjjm 5334 36 , , , cord-023095-4dannjjm 5334 37 cat cat NN cord-023095-4dannjjm 5334 38 living living NN cord-023095-4dannjjm 5334 39 style style NN cord-023095-4dannjjm 5334 40 and and CC cord-023095-4dannjjm 5334 41 owner owner NN cord-023095-4dannjjm 5334 42 's 's POS cord-023095-4dannjjm 5334 43 subjective subjective JJ cord-023095-4dannjjm 5334 44 life life NN cord-023095-4dannjjm 5334 45 quality quality NN cord-023095-4dannjjm 5334 46 . . . cord-023095-4dannjjm 5335 1 In in IN cord-023095-4dannjjm 5335 2 this this DT cord-023095-4dannjjm 5335 3 study study NN cord-023095-4dannjjm 5335 4 , , , cord-023095-4dannjjm 5335 5 adrenocortical adrenocortical JJ cord-023095-4dannjjm 5335 6 activity activity NN cord-023095-4dannjjm 5335 7 , , , cord-023095-4dannjjm 5335 8 as as IN cord-023095-4dannjjm 5335 9 a a DT cord-023095-4dannjjm 5335 10 valuable valuable JJ cord-023095-4dannjjm 5335 11 physiological physiological JJ cord-023095-4dannjjm 5335 12 indicator indicator NN cord-023095-4dannjjm 5335 13 of of IN cord-023095-4dannjjm 5335 14 emotional emotional JJ cord-023095-4dannjjm 5335 15 stress stress NN cord-023095-4dannjjm 5335 16 , , , cord-023095-4dannjjm 5335 17 was be VBD cord-023095-4dannjjm 5335 18 evaluated evaluate VBN cord-023095-4dannjjm 5335 19 throughout throughout IN cord-023095-4dannjjm 5335 20 the the DT cord-023095-4dannjjm 5335 21 measurement measurement NN cord-023095-4dannjjm 5335 22 of of IN cord-023095-4dannjjm 5335 23 faecal faecal JJ cord-023095-4dannjjm 5335 24 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 5335 25 metabolites metabolite NNS cord-023095-4dannjjm 5335 26 in in IN cord-023095-4dannjjm 5335 27 fourteen fourteen CD cord-023095-4dannjjm 5335 28 single single JJ cord-023095-4dannjjm 5335 29 and and CC cord-023095-4dannjjm 5335 30 sixteen sixteen CD cord-023095-4dannjjm 5335 31 in in IN cord-023095-4dannjjm 5335 32 - - HYPH cord-023095-4dannjjm 5335 33 group group NN cord-023095-4dannjjm 5335 34 housed house VBN cord-023095-4dannjjm 5335 35 cats cat NNS cord-023095-4dannjjm 5335 36 . . . cord-023095-4dannjjm 5336 1 Cat cat NN cord-023095-4dannjjm 5336 2 personality personality NN cord-023095-4dannjjm 5336 3 as as RB cord-023095-4dannjjm 5336 4 well well RB cord-023095-4dannjjm 5336 5 as as IN cord-023095-4dannjjm 5336 6 owners owner NNS cord-023095-4dannjjm 5336 7 life life NN cord-023095-4dannjjm 5336 8 quality quality NN cord-023095-4dannjjm 5336 9 was be VBD cord-023095-4dannjjm 5336 10 evaluated evaluate VBN cord-023095-4dannjjm 5336 11 by by IN cord-023095-4dannjjm 5336 12 self self NN cord-023095-4dannjjm 5336 13 reported report VBD cord-023095-4dannjjm 5336 14 questionnaires questionnaire NNS cord-023095-4dannjjm 5336 15 given give VBN cord-023095-4dannjjm 5336 16 to to IN cord-023095-4dannjjm 5336 17 the the DT cord-023095-4dannjjm 5336 18 owners owner NNS cord-023095-4dannjjm 5336 19 to to TO cord-023095-4dannjjm 5336 20 answer answer VB cord-023095-4dannjjm 5336 21 . . . cord-023095-4dannjjm 5337 1 Significant significant JJ cord-023095-4dannjjm 5337 2 differences difference NNS cord-023095-4dannjjm 5337 3 in in IN cord-023095-4dannjjm 5337 4 mean mean JJ cord-023095-4dannjjm 5337 5 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 5337 6 metabolites metabolite NNS cord-023095-4dannjjm 5337 7 concentrations concentration NNS cord-023095-4dannjjm 5337 8 ( ( -LRB- cord-023095-4dannjjm 5337 9 mGCM mGCM NNS cord-023095-4dannjjm 5337 10 ) ) -RRB- cord-023095-4dannjjm 5337 11 between between IN cord-023095-4dannjjm 5337 12 the the DT cord-023095-4dannjjm 5337 13 two two CD cord-023095-4dannjjm 5337 14 populations population NNS cord-023095-4dannjjm 5337 15 ( ( -LRB- cord-023095-4dannjjm 5337 16 i.e. i.e. FW cord-023095-4dannjjm 5337 17 single single JJ cord-023095-4dannjjm 5337 18 versus versus IN cord-023095-4dannjjm 5337 19 in in IN cord-023095-4dannjjm 5337 20 - - HYPH cord-023095-4dannjjm 5337 21 group group NN cord-023095-4dannjjm 5337 22 cats cat NNS cord-023095-4dannjjm 5337 23 ) ) -RRB- cord-023095-4dannjjm 5337 24 were be VBD cord-023095-4dannjjm 5337 25 not not RB cord-023095-4dannjjm 5337 26 detected detect VBN cord-023095-4dannjjm 5337 27 ( ( -LRB- cord-023095-4dannjjm 5337 28 Random random JJ cord-023095-4dannjjm 5337 29 effect effect NN cord-023095-4dannjjm 5337 30 model model NN cord-023095-4dannjjm 5337 31 , , , cord-023095-4dannjjm 5337 32 p p NN cord-023095-4dannjjm 5337 33 5 5 CD cord-023095-4dannjjm 5337 34 0.178 0.178 CD cord-023095-4dannjjm 5337 35 ) ) -RRB- cord-023095-4dannjjm 5337 36 . . . cord-023095-4dannjjm 5338 1 However however RB cord-023095-4dannjjm 5338 2 , , , cord-023095-4dannjjm 5338 3 when when WRB cord-023095-4dannjjm 5338 4 mGCM mGCM NNS cord-023095-4dannjjm 5338 5 were be VBD cord-023095-4dannjjm 5338 6 taken take VBN cord-023095-4dannjjm 5338 7 as as IN cord-023095-4dannjjm 5338 8 a a DT cord-023095-4dannjjm 5338 9 function function NN cord-023095-4dannjjm 5338 10 of of IN cord-023095-4dannjjm 5338 11 cat cat NN cord-023095-4dannjjm 5338 12 personality personality NN cord-023095-4dannjjm 5338 13 , , , cord-023095-4dannjjm 5338 14 there there EX cord-023095-4dannjjm 5338 15 were be VBD cord-023095-4dannjjm 5338 16 differences difference NNS cord-023095-4dannjjm 5338 17 regarding regard VBG cord-023095-4dannjjm 5338 18 single single JJ cord-023095-4dannjjm 5338 19 catstimid catstimid NNP cord-023095-4dannjjm 5338 20 cats cat NNS cord-023095-4dannjjm 5338 21 showed show VBD cord-023095-4dannjjm 5338 22 higher high JJR cord-023095-4dannjjm 5338 23 levels level NNS cord-023095-4dannjjm 5338 24 in in IN cord-023095-4dannjjm 5338 25 comparison comparison NN cord-023095-4dannjjm 5338 26 to to IN cord-023095-4dannjjm 5338 27 easy easy RB cord-023095-4dannjjm 5338 28 - - HYPH cord-023095-4dannjjm 5338 29 going going JJ cord-023095-4dannjjm 5338 30 ( ( -LRB- cord-023095-4dannjjm 5338 31 Random random JJ cord-023095-4dannjjm 5338 32 effect effect NN cord-023095-4dannjjm 5338 33 model model NN cord-023095-4dannjjm 5338 34 , , , cord-023095-4dannjjm 5338 35 p p NN cord-023095-4dannjjm 5338 36 5 5 CD cord-023095-4dannjjm 5338 37 0.018 0.018 CD cord-023095-4dannjjm 5338 38 ) ) -RRB- cord-023095-4dannjjm 5338 39 and and CC cord-023095-4dannjjm 5338 40 bossy bossy JJ cord-023095-4dannjjm 5338 41 ( ( -LRB- cord-023095-4dannjjm 5338 42 Random random JJ cord-023095-4dannjjm 5338 43 effect effect NN cord-023095-4dannjjm 5338 44 model model NN cord-023095-4dannjjm 5338 45 , , , cord-023095-4dannjjm 5338 46 p p NN cord-023095-4dannjjm 5338 47 5 5 CD cord-023095-4dannjjm 5338 48 0.020 0.020 CD cord-023095-4dannjjm 5338 49 ) ) -RRB- cord-023095-4dannjjm 5338 50 cats cat NNS cord-023095-4dannjjm 5338 51 . . . cord-023095-4dannjjm 5339 1 As as IN cord-023095-4dannjjm 5339 2 to to IN cord-023095-4dannjjm 5339 3 owner owner NN cord-023095-4dannjjm 5339 4 subjective subjective JJ cord-023095-4dannjjm 5339 5 life life NN cord-023095-4dannjjm 5339 6 quality quality NN cord-023095-4dannjjm 5339 7 , , , cord-023095-4dannjjm 5339 8 a a DT cord-023095-4dannjjm 5339 9 direct direct JJ cord-023095-4dannjjm 5339 10 association association NN cord-023095-4dannjjm 5339 11 between between IN cord-023095-4dannjjm 5339 12 the the DT cord-023095-4dannjjm 5339 13 scores score NNS cord-023095-4dannjjm 5339 14 given give VBN cord-023095-4dannjjm 5339 15 by by IN cord-023095-4dannjjm 5339 16 the the DT cord-023095-4dannjjm 5339 17 owners owner NNS cord-023095-4dannjjm 5339 18 to to IN cord-023095-4dannjjm 5339 19 the the DT cord-023095-4dannjjm 5339 20 social social JJ cord-023095-4dannjjm 5339 21 dimension dimension NN cord-023095-4dannjjm 5339 22 and and CC cord-023095-4dannjjm 5339 23 mGCM mGCM NNS cord-023095-4dannjjm 5339 24 was be VBD cord-023095-4dannjjm 5339 25 found find VBN cord-023095-4dannjjm 5339 26 for for IN cord-023095-4dannjjm 5339 27 single single JJ cord-023095-4dannjjm 5339 28 cats cat NNS cord-023095-4dannjjm 5339 29 only only RB cord-023095-4dannjjm 5339 30 ( ( -LRB- cord-023095-4dannjjm 5339 31 i.e. i.e. FW cord-023095-4dannjjm 5339 32 the the DT cord-023095-4dannjjm 5339 33 better well JJR cord-023095-4dannjjm 5339 34 the the DT cord-023095-4dannjjm 5339 35 owner owner NN cord-023095-4dannjjm 5339 36 felt feel VBD cord-023095-4dannjjm 5339 37 itself -PRON- PRP cord-023095-4dannjjm 5339 38 social social JJ cord-023095-4dannjjm 5339 39 wise wise RB cord-023095-4dannjjm 5339 40 the the DT cord-023095-4dannjjm 5339 41 higher high JJR cord-023095-4dannjjm 5339 42 the the DT cord-023095-4dannjjm 5339 43 mGCM mGCM NNS cord-023095-4dannjjm 5339 44 of of IN cord-023095-4dannjjm 5339 45 the the DT cord-023095-4dannjjm 5339 46 cat cat NN cord-023095-4dannjjm 5339 47 ; ; : cord-023095-4dannjjm 5339 48 Random random JJ cord-023095-4dannjjm 5339 49 effect effect NN cord-023095-4dannjjm 5339 50 model model NN cord-023095-4dannjjm 5339 51 , , , cord-023095-4dannjjm 5339 52 p p NN cord-023095-4dannjjm 5339 53 5 5 CD cord-023095-4dannjjm 5339 54 0.002 0.002 CD cord-023095-4dannjjm 5339 55 ) ) -RRB- cord-023095-4dannjjm 5339 56 . . . cord-023095-4dannjjm 5340 1 Social social JJ cord-023095-4dannjjm 5340 2 stratification stratification NN cord-023095-4dannjjm 5340 3 may may MD cord-023095-4dannjjm 5340 4 compensate compensate VB cord-023095-4dannjjm 5340 5 the the DT cord-023095-4dannjjm 5340 6 stress stress NN cord-023095-4dannjjm 5340 7 resulting result VBG cord-023095-4dannjjm 5340 8 from from IN cord-023095-4dannjjm 5340 9 spatial spatial JJ cord-023095-4dannjjm 5340 10 restriction restriction NN cord-023095-4dannjjm 5340 11 in in IN cord-023095-4dannjjm 5340 12 large large JJ cord-023095-4dannjjm 5340 13 in in IN cord-023095-4dannjjm 5340 14 - - HYPH cord-023095-4dannjjm 5340 15 group group NN cord-023095-4dannjjm 5340 16 living living NN cord-023095-4dannjjm 5340 17 cats cat NNS cord-023095-4dannjjm 5340 18 . . . cord-023095-4dannjjm 5341 1 Other other JJ cord-023095-4dannjjm 5341 2 underexplored underexplored JJ cord-023095-4dannjjm 5341 3 factors factor NNS cord-023095-4dannjjm 5341 4 such such JJ cord-023095-4dannjjm 5341 5 as as IN cord-023095-4dannjjm 5341 6 feline feline JJ cord-023095-4dannjjm 5341 7 personality personality NN cord-023095-4dannjjm 5341 8 and and CC cord-023095-4dannjjm 5341 9 owner owner NN cord-023095-4dannjjm 5341 10 life life NN cord-023095-4dannjjm 5341 11 style style NN cord-023095-4dannjjm 5341 12 seem seem VBP cord-023095-4dannjjm 5341 13 to to TO cord-023095-4dannjjm 5341 14 play play VB cord-023095-4dannjjm 5341 15 an an DT cord-023095-4dannjjm 5341 16 equally equally RB cord-023095-4dannjjm 5341 17 important important JJ cord-023095-4dannjjm 5341 18 role role NN cord-023095-4dannjjm 5341 19 in in IN cord-023095-4dannjjm 5341 20 domestic domestic JJ cord-023095-4dannjjm 5341 21 cats cat NNS cord-023095-4dannjjm 5341 22 ' ' POS cord-023095-4dannjjm 5341 23 day day NN cord-023095-4dannjjm 5341 24 to to IN cord-023095-4dannjjm 5341 25 day day NN cord-023095-4dannjjm 5341 26 levels level NNS cord-023095-4dannjjm 5341 27 of of IN cord-023095-4dannjjm 5341 28 stress stress NN cord-023095-4dannjjm 5341 29 , , , cord-023095-4dannjjm 5341 30 especially especially RB cord-023095-4dannjjm 5341 31 in in IN cord-023095-4dannjjm 5341 32 the the DT cord-023095-4dannjjm 5341 33 cats cat NNS cord-023095-4dannjjm 5341 34 kept keep VBD cord-023095-4dannjjm 5341 35 as as IN cord-023095-4dannjjm 5341 36 single single JJ cord-023095-4dannjjm 5341 37 pets pet NNS cord-023095-4dannjjm 5341 38 . . . cord-023095-4dannjjm 5342 1 In in IN cord-023095-4dannjjm 5342 2 dogs dog NNS cord-023095-4dannjjm 5342 3 , , , cord-023095-4dannjjm 5342 4 RAAS RAAS NNP cord-023095-4dannjjm 5342 5 activation activation NN cord-023095-4dannjjm 5342 6 is be VBZ cord-023095-4dannjjm 5342 7 a a DT cord-023095-4dannjjm 5342 8 major major JJ cord-023095-4dannjjm 5342 9 feature feature NN cord-023095-4dannjjm 5342 10 of of IN cord-023095-4dannjjm 5342 11 congestive congestive JJ cord-023095-4dannjjm 5342 12 heart heart NN cord-023095-4dannjjm 5342 13 failure failure NN cord-023095-4dannjjm 5342 14 ( ( -LRB- cord-023095-4dannjjm 5342 15 CHF CHF NNP cord-023095-4dannjjm 5342 16 ) ) -RRB- cord-023095-4dannjjm 5342 17 . . . cord-023095-4dannjjm 5343 1 Benazepril Benazepril NNP cord-023095-4dannjjm 5343 2 ( ( -LRB- cord-023095-4dannjjm 5343 3 Fortekor Fortekor NNP cord-023095-4dannjjm 5343 4 s s NNP cord-023095-4dannjjm 5343 5 ) ) -RRB- cord-023095-4dannjjm 5343 6 is be VBZ cord-023095-4dannjjm 5343 7 a a DT cord-023095-4dannjjm 5343 8 potent potent JJ cord-023095-4dannjjm 5343 9 ACE ace NN cord-023095-4dannjjm 5343 10 inhibitor inhibitor NN cord-023095-4dannjjm 5343 11 with with IN cord-023095-4dannjjm 5343 12 well well RB cord-023095-4dannjjm 5343 13 - - HYPH cord-023095-4dannjjm 5343 14 documented document VBN cord-023095-4dannjjm 5343 15 effectiveness effectiveness NN cord-023095-4dannjjm 5343 16 in in IN cord-023095-4dannjjm 5343 17 canine canine JJ cord-023095-4dannjjm 5343 18 CHF CHF NNP cord-023095-4dannjjm 5343 19 . . . cord-023095-4dannjjm 5344 1 Although although IN cord-023095-4dannjjm 5344 2 ACE ace NN cord-023095-4dannjjm 5344 3 activity activity NN cord-023095-4dannjjm 5344 4 ( ( -LRB- cord-023095-4dannjjm 5344 5 ACE ACE NNP cord-023095-4dannjjm 5344 6 A A NNP cord-023095-4dannjjm 5344 7 ) ) -RRB- cord-023095-4dannjjm 5344 8 has have VBZ cord-023095-4dannjjm 5344 9 been be VBN cord-023095-4dannjjm 5344 10 used use VBN cord-023095-4dannjjm 5344 11 in in IN cord-023095-4dannjjm 5344 12 preclinical preclinical JJ cord-023095-4dannjjm 5344 13 studies study NNS cord-023095-4dannjjm 5344 14 as as IN cord-023095-4dannjjm 5344 15 a a DT cord-023095-4dannjjm 5344 16 surrogate surrogate JJ cord-023095-4dannjjm 5344 17 marker marker NN cord-023095-4dannjjm 5344 18 of of IN cord-023095-4dannjjm 5344 19 efficacy efficacy NN cord-023095-4dannjjm 5344 20 , , , cord-023095-4dannjjm 5344 21 some some DT cord-023095-4dannjjm 5344 22 authors author NNS cord-023095-4dannjjm 5344 23 have have VBP cord-023095-4dannjjm 5344 24 reported report VBN cord-023095-4dannjjm 5344 25 a a DT cord-023095-4dannjjm 5344 26 poor poor JJ cord-023095-4dannjjm 5344 27 correlation correlation NN cord-023095-4dannjjm 5344 28 between between IN cord-023095-4dannjjm 5344 29 plasma plasma NN cord-023095-4dannjjm 5344 30 ACE ACE NNP cord-023095-4dannjjm 5344 31 A A NNP cord-023095-4dannjjm 5344 32 and and CC cord-023095-4dannjjm 5344 33 changes change VBZ cord-023095-4dannjjm 5344 34 in in IN cord-023095-4dannjjm 5344 35 angiotensin angiotensin NN cord-023095-4dannjjm 5344 36 II II NNP cord-023095-4dannjjm 5344 37 ( ( -LRB- cord-023095-4dannjjm 5344 38 AII AII NNP cord-023095-4dannjjm 5344 39 ) ) -RRB- cord-023095-4dannjjm 5344 40 or or CC cord-023095-4dannjjm 5344 41 aldosterone aldosterone NN cord-023095-4dannjjm 5344 42 ( ( -LRB- cord-023095-4dannjjm 5344 43 AL AL NNP cord-023095-4dannjjm 5344 44 ) ) -RRB- cord-023095-4dannjjm 5344 45 . . . cord-023095-4dannjjm 5345 1 The the DT cord-023095-4dannjjm 5345 2 purpose purpose NN cord-023095-4dannjjm 5345 3 of of IN cord-023095-4dannjjm 5345 4 this this DT cord-023095-4dannjjm 5345 5 study study NN cord-023095-4dannjjm 5345 6 was be VBD cord-023095-4dannjjm 5345 7 to to TO cord-023095-4dannjjm 5345 8 investigate investigate VB cord-023095-4dannjjm 5345 9 the the DT cord-023095-4dannjjm 5345 10 effect effect NN cord-023095-4dannjjm 5345 11 of of IN cord-023095-4dannjjm 5345 12 benazepril benazepril NNP cord-023095-4dannjjm 5345 13 on on IN cord-023095-4dannjjm 5345 14 canine canine JJ cord-023095-4dannjjm 5345 15 plasma plasma NN cord-023095-4dannjjm 5345 16 renin renin NN cord-023095-4dannjjm 5345 17 activity activity NN cord-023095-4dannjjm 5345 18 / / SYM cord-023095-4dannjjm 5345 19 concentration concentration NN cord-023095-4dannjjm 5345 20 ( ( -LRB- cord-023095-4dannjjm 5345 21 PRA PRA NNP cord-023095-4dannjjm 5345 22 / / SYM cord-023095-4dannjjm 5345 23 PRC PRC NNP cord-023095-4dannjjm 5345 24 ) ) -RRB- cord-023095-4dannjjm 5345 25 , , , cord-023095-4dannjjm 5345 26 angiotensin angiotensin NN cord-023095-4dannjjm 5345 27 I -PRON- PRP cord-023095-4dannjjm 5345 28 ( ( -LRB- cord-023095-4dannjjm 5345 29 AI AI NNP cord-023095-4dannjjm 5345 30 ) ) -RRB- cord-023095-4dannjjm 5345 31 , , , cord-023095-4dannjjm 5345 32 AII AII NNP cord-023095-4dannjjm 5345 33 , , , cord-023095-4dannjjm 5345 34 AL AL NNP cord-023095-4dannjjm 5345 35 , , , cord-023095-4dannjjm 5345 36 and and CC cord-023095-4dannjjm 5345 37 fractional fractional JJ cord-023095-4dannjjm 5345 38 excretion excretion NN cord-023095-4dannjjm 5345 39 of of IN cord-023095-4dannjjm 5345 40 potassium potassium NN cord-023095-4dannjjm 5345 41 ( ( -LRB- cord-023095-4dannjjm 5345 42 UfeK UfeK NNP cord-023095-4dannjjm 5345 43 ) ) -RRB- cord-023095-4dannjjm 5345 44 , , , cord-023095-4dannjjm 5345 45 sodium sodium NN cord-023095-4dannjjm 5345 46 ( ( -LRB- cord-023095-4dannjjm 5345 47 UfeNa UfeNa NNP cord-023095-4dannjjm 5345 48 ) ) -RRB- cord-023095-4dannjjm 5345 49 and and CC cord-023095-4dannjjm 5345 50 aldosterone aldosterone NN cord-023095-4dannjjm 5345 51 ( ( -LRB- cord-023095-4dannjjm 5345 52 UfeAL UfeAL NNP cord-023095-4dannjjm 5345 53 ) ) -RRB- cord-023095-4dannjjm 5345 54 . . . cord-023095-4dannjjm 5346 1 Sixteen sixteen CD cord-023095-4dannjjm 5346 2 beagle beagle NN cord-023095-4dannjjm 5346 3 dogs dog NNS cord-023095-4dannjjm 5346 4 were be VBD cord-023095-4dannjjm 5346 5 fed feed VBN cord-023095-4dannjjm 5346 6 a a DT cord-023095-4dannjjm 5346 7 low low JJ cord-023095-4dannjjm 5346 8 - - HYPH cord-023095-4dannjjm 5346 9 sodium sodium NN cord-023095-4dannjjm 5346 10 diet diet NN cord-023095-4dannjjm 5346 11 and and CC cord-023095-4dannjjm 5346 12 dosed dose VBN cord-023095-4dannjjm 5346 13 with with IN cord-023095-4dannjjm 5346 14 placebo placebo NN cord-023095-4dannjjm 5346 15 or or CC cord-023095-4dannjjm 5346 16 benazepril benazepril NNP cord-023095-4dannjjm 5346 17 tablets tablets NNP cord-023095-4dannjjm 5346 18 ( ( -LRB- cord-023095-4dannjjm 5346 19 10 10 CD cord-023095-4dannjjm 5346 20 mg mg NNP cord-023095-4dannjjm 5346 21 PO po NN cord-023095-4dannjjm 5346 22 , , , cord-023095-4dannjjm 5346 23 q24h q24h CD cord-023095-4dannjjm 5346 24 ) ) -RRB- cord-023095-4dannjjm 5346 25 for for IN cord-023095-4dannjjm 5346 26 5 5 CD cord-023095-4dannjjm 5346 27 days day NNS cord-023095-4dannjjm 5346 28 . . . cord-023095-4dannjjm 5347 1 Blood blood NN cord-023095-4dannjjm 5347 2 and and CC cord-023095-4dannjjm 5347 3 urine urine NN cord-023095-4dannjjm 5347 4 samples sample NNS cord-023095-4dannjjm 5347 5 were be VBD cord-023095-4dannjjm 5347 6 collected collect VBN cord-023095-4dannjjm 5347 7 on on IN cord-023095-4dannjjm 5347 8 day day NN cord-023095-4dannjjm 5347 9 1 1 CD cord-023095-4dannjjm 5347 10 ( ( -LRB- cord-023095-4dannjjm 5347 11 D1 D1 NNP cord-023095-4dannjjm 5347 12 ) ) -RRB- cord-023095-4dannjjm 5347 13 and and CC cord-023095-4dannjjm 5347 14 day day NN cord-023095-4dannjjm 5347 15 5 5 CD cord-023095-4dannjjm 5347 16 ( ( -LRB- cord-023095-4dannjjm 5347 17 D5 D5 NNP cord-023095-4dannjjm 5347 18 ) ) -RRB- cord-023095-4dannjjm 5347 19 over over IN cord-023095-4dannjjm 5347 20 24-hour 24-hour JJ cord-023095-4dannjjm 5347 21 periods period NNS cord-023095-4dannjjm 5347 22 . . . cord-023095-4dannjjm 5348 1 Data datum NNS cord-023095-4dannjjm 5348 2 were be VBD cord-023095-4dannjjm 5348 3 analyzed analyze VBN cord-023095-4dannjjm 5348 4 by by IN cord-023095-4dannjjm 5348 5 repeated repeat VBN cord-023095-4dannjjm 5348 6 measures measure NNS cord-023095-4dannjjm 5348 7 ANOVA ANOVA NNP cord-023095-4dannjjm 5348 8 of of IN cord-023095-4dannjjm 5348 9 baseline baseline JJ cord-023095-4dannjjm 5348 10 corrected correct VBN cord-023095-4dannjjm 5348 11 values value NNS cord-023095-4dannjjm 5348 12 , , , cord-023095-4dannjjm 5348 13 and and CC cord-023095-4dannjjm 5348 14 ANOVA ANOVA NNP cord-023095-4dannjjm 5348 15 of of IN cord-023095-4dannjjm 5348 16 AUC AUC NNP cord-023095-4dannjjm 5348 17 24hours 24hours CD cord-023095-4dannjjm 5348 18 . . . cord-023095-4dannjjm 5349 1 Compared compare VBN cord-023095-4dannjjm 5349 2 with with IN cord-023095-4dannjjm 5349 3 placebo placebo NN cord-023095-4dannjjm 5349 4 , , , cord-023095-4dannjjm 5349 5 benazepril benazepril NNP cord-023095-4dannjjm 5349 6 induced induce VBD cord-023095-4dannjjm 5349 7 a a DT cord-023095-4dannjjm 5349 8 significant significant JJ cord-023095-4dannjjm 5349 9 increase increase NN cord-023095-4dannjjm 5349 10 in in IN cord-023095-4dannjjm 5349 11 PRA PRA NNP cord-023095-4dannjjm 5349 12 and and CC cord-023095-4dannjjm 5349 13 AI AI NNP cord-023095-4dannjjm 5349 14 at at IN cord-023095-4dannjjm 5349 15 D1 d1 NN cord-023095-4dannjjm 5349 16 ( ( -LRB- cord-023095-4dannjjm 5349 17 p p NN cord-023095-4dannjjm 5349 18 - - HYPH cord-023095-4dannjjm 5349 19 value value NN cord-023095-4dannjjm 5349 20 [ [ -LRB- cord-023095-4dannjjm 5349 21 PRA PRA NNP cord-023095-4dannjjm 5349 22 ] ] -RRB- cord-023095-4dannjjm 5349 23 : : : cord-023095-4dannjjm 5349 24 0.001 0.001 CD cord-023095-4dannjjm 5349 25 , , , cord-023095-4dannjjm 5349 26 p p NN cord-023095-4dannjjm 5349 27 - - HYPH cord-023095-4dannjjm 5349 28 value value NN cord-023095-4dannjjm 5349 29 [ [ -LRB- cord-023095-4dannjjm 5349 30 AI ai NN cord-023095-4dannjjm 5349 31 ] ] -RRB- cord-023095-4dannjjm 5349 32 : : : cord-023095-4dannjjm 5349 33 0.002 0.002 CD cord-023095-4dannjjm 5349 34 ) ) -RRB- cord-023095-4dannjjm 5349 35 and and CC cord-023095-4dannjjm 5349 36 D5 D5 NNP cord-023095-4dannjjm 5349 37 ( ( -LRB- cord-023095-4dannjjm 5349 38 p p NN cord-023095-4dannjjm 5349 39 - - HYPH cord-023095-4dannjjm 5349 40 value value NN cord-023095-4dannjjm 5349 41 [ [ -LRB- cord-023095-4dannjjm 5349 42 PRA PRA NNP cord-023095-4dannjjm 5349 43 ] ] -RRB- cord-023095-4dannjjm 5349 44 : : : cord-023095-4dannjjm 5349 45 0.001 0.001 CD cord-023095-4dannjjm 5349 46 , , , cord-023095-4dannjjm 5349 47 p p NN cord-023095-4dannjjm 5349 48 - - HYPH cord-023095-4dannjjm 5349 49 value value NN cord-023095-4dannjjm 5349 50 [ [ -LRB- cord-023095-4dannjjm 5349 51 AI ai NN cord-023095-4dannjjm 5349 52 ] ] -RRB- cord-023095-4dannjjm 5349 53 o o NN cord-023095-4dannjjm 5349 54 0.001 0.001 CD cord-023095-4dannjjm 5349 55 ) ) -RRB- cord-023095-4dannjjm 5349 56 . . . cord-023095-4dannjjm 5350 1 No no DT cord-023095-4dannjjm 5350 2 differences difference NNS cord-023095-4dannjjm 5350 3 in in IN cord-023095-4dannjjm 5350 4 PRC PRC NNP cord-023095-4dannjjm 5350 5 were be VBD cord-023095-4dannjjm 5350 6 noticed notice VBN cord-023095-4dannjjm 5350 7 . . . cord-023095-4dannjjm 5351 1 Based base VBN cord-023095-4dannjjm 5351 2 on on IN cord-023095-4dannjjm 5351 3 AUC AUC NNP cord-023095-4dannjjm 5351 4 24hours 24hours CD cord-023095-4dannjjm 5351 5 , , , cord-023095-4dannjjm 5351 6 AII AII NNP cord-023095-4dannjjm 5351 7 levels level NNS cord-023095-4dannjjm 5351 8 were be VBD cord-023095-4dannjjm 5351 9 34 34 CD cord-023095-4dannjjm 5351 10 % % NN cord-023095-4dannjjm 5351 11 lower low JJR cord-023095-4dannjjm 5351 12 in in IN cord-023095-4dannjjm 5351 13 the the DT cord-023095-4dannjjm 5351 14 benazepril benazepril NNP cord-023095-4dannjjm 5351 15 group group NN cord-023095-4dannjjm 5351 16 at at IN cord-023095-4dannjjm 5351 17 D5 D5 NNP cord-023095-4dannjjm 5351 18 ( ( -LRB- cord-023095-4dannjjm 5351 19 p p NN cord-023095-4dannjjm 5351 20 - - HYPH cord-023095-4dannjjm 5351 21 value value NN cord-023095-4dannjjm 5351 22 [ [ -LRB- cord-023095-4dannjjm 5351 23 AII AII NNP cord-023095-4dannjjm 5351 24 ] ] -RRB- cord-023095-4dannjjm 5351 25 : : : cord-023095-4dannjjm 5351 26 0.01 0.01 CD cord-023095-4dannjjm 5351 27 ) ) -RRB- cord-023095-4dannjjm 5351 28 . . . cord-023095-4dannjjm 5352 1 UfeAL UfeAL NNP cord-023095-4dannjjm 5352 2 and and CC cord-023095-4dannjjm 5352 3 AL AL NNP cord-023095-4dannjjm 5352 4 decreased decrease VBD cord-023095-4dannjjm 5352 5 by by IN cord-023095-4dannjjm 5352 6 up up IN cord-023095-4dannjjm 5352 7 to to TO cord-023095-4dannjjm 5352 8 27 27 CD cord-023095-4dannjjm 5352 9 % % NN cord-023095-4dannjjm 5352 10 and and CC cord-023095-4dannjjm 5352 11 24 24 CD cord-023095-4dannjjm 5352 12 % % NN cord-023095-4dannjjm 5352 13 at at IN cord-023095-4dannjjm 5352 14 D1 d1 NN cord-023095-4dannjjm 5352 15 and and CC cord-023095-4dannjjm 5352 16 D5 D5 NNP cord-023095-4dannjjm 5352 17 , , , cord-023095-4dannjjm 5352 18 respectively respectively RB cord-023095-4dannjjm 5352 19 , , , cord-023095-4dannjjm 5352 20 though though IN cord-023095-4dannjjm 5352 21 differences difference NNS cord-023095-4dannjjm 5352 22 did do VBD cord-023095-4dannjjm 5352 23 not not RB cord-023095-4dannjjm 5352 24 reach reach VB cord-023095-4dannjjm 5352 25 statistical statistical JJ cord-023095-4dannjjm 5352 26 significance significance NN cord-023095-4dannjjm 5352 27 . . . cord-023095-4dannjjm 5353 1 Benazepril Benazepril NNP cord-023095-4dannjjm 5353 2 markedly markedly RB cord-023095-4dannjjm 5353 3 influences influence VBZ cord-023095-4dannjjm 5353 4 RAAS RAAS NNP cord-023095-4dannjjm 5353 5 dynamics dynamic NNS cord-023095-4dannjjm 5353 6 in in IN cord-023095-4dannjjm 5353 7 dogs dog NNS cord-023095-4dannjjm 5353 8 . . . cord-023095-4dannjjm 5354 1 Decreased decrease VBN cord-023095-4dannjjm 5354 2 exposure exposure NN cord-023095-4dannjjm 5354 3 to to IN cord-023095-4dannjjm 5354 4 AII AII NNP cord-023095-4dannjjm 5354 5 and and CC cord-023095-4dannjjm 5354 6 AL AL NNP cord-023095-4dannjjm 5354 7 are be VBP cord-023095-4dannjjm 5354 8 likely likely JJ cord-023095-4dannjjm 5354 9 to to TO cord-023095-4dannjjm 5354 10 be be VB cord-023095-4dannjjm 5354 11 the the DT cord-023095-4dannjjm 5354 12 key key JJ cord-023095-4dannjjm 5354 13 events event NNS cord-023095-4dannjjm 5354 14 required require VBN cord-023095-4dannjjm 5354 15 to to TO cord-023095-4dannjjm 5354 16 counteract counteract VB cord-023095-4dannjjm 5354 17 pathological pathological JJ cord-023095-4dannjjm 5354 18 remodeling remodeling NN cord-023095-4dannjjm 5354 19 of of IN cord-023095-4dannjjm 5354 20 the the DT cord-023095-4dannjjm 5354 21 heart heart NN cord-023095-4dannjjm 5354 22 in in IN cord-023095-4dannjjm 5354 23 CHF CHF NNP cord-023095-4dannjjm 5354 24 . . . cord-023095-4dannjjm 5355 1 This this DT cord-023095-4dannjjm 5355 2 study study NN cord-023095-4dannjjm 5355 3 compared compare VBD cord-023095-4dannjjm 5355 4 two two CD cord-023095-4dannjjm 5355 5 intravenous intravenous JJ cord-023095-4dannjjm 5355 6 anesthetic anesthetic JJ cord-023095-4dannjjm 5355 7 agents agent NNS cord-023095-4dannjjm 5355 8 , , , cord-023095-4dannjjm 5355 9 alfaxalone alfaxalone NN cord-023095-4dannjjm 5355 10 ( ( -LRB- cord-023095-4dannjjm 5355 11 ALF ALF NNP cord-023095-4dannjjm 5355 12 ) ) -RRB- cord-023095-4dannjjm 5355 13 ( ( -LRB- cord-023095-4dannjjm 5355 14 Alfaxan Alfaxan NNP cord-023095-4dannjjm 5355 15 s s NNP cord-023095-4dannjjm 5355 16 , , , cord-023095-4dannjjm 5355 17 Jurox Jurox NNP cord-023095-4dannjjm 5355 18 Pty Pty NNP cord-023095-4dannjjm 5355 19 . . . cord-023095-4dannjjm 5355 20 Ltd. Ltd. NNP cord-023095-4dannjjm 5355 21 ) ) -RRB- cord-023095-4dannjjm 5356 1 and and CC cord-023095-4dannjjm 5356 2 propofol propofol NN cord-023095-4dannjjm 5356 3 ( ( -LRB- cord-023095-4dannjjm 5356 4 PPF PPF NNP cord-023095-4dannjjm 5356 5 ) ) -RRB- cord-023095-4dannjjm 5356 6 ( ( -LRB- cord-023095-4dannjjm 5356 7 Rapinovet Rapinovet NNP cord-023095-4dannjjm 5356 8 s s POS cord-023095-4dannjjm 5356 9 , , , cord-023095-4dannjjm 5356 10 Schering Schering NNP cord-023095-4dannjjm 5356 11 Plough Plough NNP cord-023095-4dannjjm 5356 12 Animal Animal NNP cord-023095-4dannjjm 5356 13 Health Health NNP cord-023095-4dannjjm 5356 14 ) ) -RRB- cord-023095-4dannjjm 5356 15 and and CC cord-023095-4dannjjm 5356 16 their -PRON- PRP$ cord-023095-4dannjjm 5356 17 effects effect NNS cord-023095-4dannjjm 5356 18 on on IN cord-023095-4dannjjm 5356 19 spontaneous spontaneous JJ cord-023095-4dannjjm 5356 20 ventilation ventilation NN cord-023095-4dannjjm 5356 21 after after IN cord-023095-4dannjjm 5356 22 induction induction NN cord-023095-4dannjjm 5356 23 of of IN cord-023095-4dannjjm 5356 24 anesthesia anesthesia NN cord-023095-4dannjjm 5356 25 in in IN cord-023095-4dannjjm 5356 26 dogs dog NNS cord-023095-4dannjjm 5356 27 at at IN cord-023095-4dannjjm 5356 28 various various JJ cord-023095-4dannjjm 5356 29 doses dose NNS cord-023095-4dannjjm 5356 30 . . . cord-023095-4dannjjm 5357 1 This this DT cord-023095-4dannjjm 5357 2 randomized randomized JJ cord-023095-4dannjjm 5357 3 , , , cord-023095-4dannjjm 5357 4 crossover crossover NN cord-023095-4dannjjm 5357 5 , , , cord-023095-4dannjjm 5357 6 dose dose NN cord-023095-4dannjjm 5357 7 - - HYPH cord-023095-4dannjjm 5357 8 escalation escalation NN cord-023095-4dannjjm 5357 9 study study NN cord-023095-4dannjjm 5357 10 used use VBD cord-023095-4dannjjm 5357 11 six six CD cord-023095-4dannjjm 5357 12 dogs dog NNS cord-023095-4dannjjm 5357 13 in in IN cord-023095-4dannjjm 5357 14 weight weight NN cord-023095-4dannjjm 5357 15 and and CC cord-023095-4dannjjm 5357 16 gender gender NN cord-023095-4dannjjm 5357 17 - - HYPH cord-023095-4dannjjm 5357 18 matched match VBN cord-023095-4dannjjm 5357 19 pairs pair NNS cord-023095-4dannjjm 5357 20 ( ( -LRB- cord-023095-4dannjjm 5357 21 3M-3F 3m-3f CD cord-023095-4dannjjm 5357 22 ) ) -RRB- cord-023095-4dannjjm 5357 23 . . . cord-023095-4dannjjm 5358 1 For for IN cord-023095-4dannjjm 5358 2 each each DT cord-023095-4dannjjm 5358 3 drug drug NN cord-023095-4dannjjm 5358 4 , , , cord-023095-4dannjjm 5358 5 each each DT cord-023095-4dannjjm 5358 6 dog dog NN cord-023095-4dannjjm 5358 7 was be VBD cord-023095-4dannjjm 5358 8 dosed dose VBN cord-023095-4dannjjm 5358 9 incrementally incrementally RB cord-023095-4dannjjm 5358 10 at at IN cord-023095-4dannjjm 5358 11 1 1 CD cord-023095-4dannjjm 5358 12 , , , cord-023095-4dannjjm 5358 13 2 2 CD cord-023095-4dannjjm 5358 14 , , , cord-023095-4dannjjm 5358 15 5 5 CD cord-023095-4dannjjm 5358 16 , , , cord-023095-4dannjjm 5358 17 10 10 CD cord-023095-4dannjjm 5358 18 and and CC cord-023095-4dannjjm 5358 19 20 20 CD cord-023095-4dannjjm 5358 20 times time NNS cord-023095-4dannjjm 5358 21 the the DT cord-023095-4dannjjm 5358 22 labeled label VBN cord-023095-4dannjjm 5358 23 anesthetic anesthetic JJ cord-023095-4dannjjm 5358 24 induction induction NN cord-023095-4dannjjm 5358 25 dose dose NN cord-023095-4dannjjm 5358 26 rate rate NN cord-023095-4dannjjm 5358 27 ( ( -LRB- cord-023095-4dannjjm 5358 28 ALF ALF NNP cord-023095-4dannjjm 5358 29 2 2 CD cord-023095-4dannjjm 5358 30 mg mg NNP cord-023095-4dannjjm 5358 31 / / SYM cord-023095-4dannjjm 5358 32 kg kg NNP cord-023095-4dannjjm 5358 33 , , , cord-023095-4dannjjm 5358 34 PPF PPF NNP cord-023095-4dannjjm 5358 35 6.5 6.5 CD cord-023095-4dannjjm 5358 36 mg mg NNP cord-023095-4dannjjm 5358 37 / / SYM cord-023095-4dannjjm 5358 38 kg kg NNP cord-023095-4dannjjm 5358 39 ) ) -RRB- cord-023095-4dannjjm 5358 40 or or CC cord-023095-4dannjjm 5358 41 until until IN cord-023095-4dannjjm 5358 42 a a DT cord-023095-4dannjjm 5358 43 dose dose NN cord-023095-4dannjjm 5358 44 was be VBD cord-023095-4dannjjm 5358 45 reached reach VBN cord-023095-4dannjjm 5358 46 that that WDT cord-023095-4dannjjm 5358 47 rendered render VBD cord-023095-4dannjjm 5358 48 the the DT cord-023095-4dannjjm 5358 49 dog dog NN cord-023095-4dannjjm 5358 50 apneic apneic JJ cord-023095-4dannjjm 5358 51 . . . cord-023095-4dannjjm 5359 1 A a DT cord-023095-4dannjjm 5359 2 minimum minimum NN cord-023095-4dannjjm 5359 3 of of IN cord-023095-4dannjjm 5359 4 three three CD cord-023095-4dannjjm 5359 5 days day NNS cord-023095-4dannjjm 5359 6 was be VBD cord-023095-4dannjjm 5359 7 allowed allow VBN cord-023095-4dannjjm 5359 8 between between IN cord-023095-4dannjjm 5359 9 doses dose NNS cord-023095-4dannjjm 5359 10 . . . cord-023095-4dannjjm 5360 1 For for IN cord-023095-4dannjjm 5360 2 each each DT cord-023095-4dannjjm 5360 3 dose dose JJ cord-023095-4dannjjm 5360 4 administration administration NN cord-023095-4dannjjm 5360 5 , , , cord-023095-4dannjjm 5360 6 the the DT cord-023095-4dannjjm 5360 7 entire entire JJ cord-023095-4dannjjm 5360 8 calculated calculate VBN cord-023095-4dannjjm 5360 9 dose dose NN cord-023095-4dannjjm 5360 10 was be VBD cord-023095-4dannjjm 5360 11 delivered deliver VBN cord-023095-4dannjjm 5360 12 constantly constantly RB cord-023095-4dannjjm 5360 13 over over IN cord-023095-4dannjjm 5360 14 1 1 CD cord-023095-4dannjjm 5360 15 min min NN cord-023095-4dannjjm 5360 16 . . . cord-023095-4dannjjm 5361 1 The the DT cord-023095-4dannjjm 5361 2 primary primary JJ cord-023095-4dannjjm 5361 3 variable variable NN cord-023095-4dannjjm 5361 4 was be VBD cord-023095-4dannjjm 5361 5 apnea apnea NN cord-023095-4dannjjm 5361 6 , , , cord-023095-4dannjjm 5361 7 defined define VBN cord-023095-4dannjjm 5361 8 as as IN cord-023095-4dannjjm 5361 9 an an DT cord-023095-4dannjjm 5361 10 absence absence NN cord-023095-4dannjjm 5361 11 of of IN cord-023095-4dannjjm 5361 12 spontaneous spontaneous JJ cord-023095-4dannjjm 5361 13 ventilation ventilation NN cord-023095-4dannjjm 5361 14 for for IN cord-023095-4dannjjm 5361 15 1 1 CD cord-023095-4dannjjm 5361 16 minute minute NN cord-023095-4dannjjm 5361 17 . . . cord-023095-4dannjjm 5362 1 Apneic Apneic NNP cord-023095-4dannjjm 5362 2 dogs dog NNS cord-023095-4dannjjm 5362 3 were be VBD cord-023095-4dannjjm 5362 4 manually manually RB cord-023095-4dannjjm 5362 5 ventilated ventilate VBN cord-023095-4dannjjm 5362 6 with with IN cord-023095-4dannjjm 5362 7 oxygen oxygen NN cord-023095-4dannjjm 5362 8 until until IN cord-023095-4dannjjm 5362 9 they -PRON- PRP cord-023095-4dannjjm 5362 10 resumed resume VBD cord-023095-4dannjjm 5362 11 adequate adequate JJ cord-023095-4dannjjm 5362 12 spontaneous spontaneous JJ cord-023095-4dannjjm 5362 13 ventilation ventilation NN cord-023095-4dannjjm 5362 14 . . . cord-023095-4dannjjm 5363 1 Once once IN cord-023095-4dannjjm 5363 2 the the DT cord-023095-4dannjjm 5363 3 apneic apneic JJ cord-023095-4dannjjm 5363 4 dose dose NN cord-023095-4dannjjm 5363 5 was be VBD cord-023095-4dannjjm 5363 6 determined determine VBN cord-023095-4dannjjm 5363 7 for for IN cord-023095-4dannjjm 5363 8 an an DT cord-023095-4dannjjm 5363 9 individual individual JJ cord-023095-4dannjjm 5363 10 dog dog NN cord-023095-4dannjjm 5363 11 for for IN cord-023095-4dannjjm 5363 12 one one CD cord-023095-4dannjjm 5363 13 drug drug NN cord-023095-4dannjjm 5363 14 , , , cord-023095-4dannjjm 5363 15 the the DT cord-023095-4dannjjm 5363 16 dog dog NN cord-023095-4dannjjm 5363 17 began begin VBD cord-023095-4dannjjm 5363 18 incremental incremental JJ cord-023095-4dannjjm 5363 19 doses dose NNS cord-023095-4dannjjm 5363 20 with with IN cord-023095-4dannjjm 5363 21 the the DT cord-023095-4dannjjm 5363 22 alternate alternate JJ cord-023095-4dannjjm 5363 23 drug drug NN cord-023095-4dannjjm 5363 24 . . . cord-023095-4dannjjm 5364 1 For for IN cord-023095-4dannjjm 5364 2 each each DT cord-023095-4dannjjm 5364 3 anesthetic anesthetic JJ cord-023095-4dannjjm 5364 4 episode episode NN cord-023095-4dannjjm 5364 5 times time NNS cord-023095-4dannjjm 5364 6 were be VBD cord-023095-4dannjjm 5364 7 recorded record VBN cord-023095-4dannjjm 5364 8 from from IN cord-023095-4dannjjm 5364 9 completion completion NN cord-023095-4dannjjm 5364 10 of of IN cord-023095-4dannjjm 5364 11 induction induction NN cord-023095-4dannjjm 5364 12 dose dose NN cord-023095-4dannjjm 5364 13 to to IN cord-023095-4dannjjm 5364 14 ; ; : cord-023095-4dannjjm 5364 15 removal removal NN cord-023095-4dannjjm 5364 16 of of IN cord-023095-4dannjjm 5364 17 endotracheal endotracheal NN cord-023095-4dannjjm 5364 18 tube tube NN cord-023095-4dannjjm 5364 19 , , , cord-023095-4dannjjm 5364 20 dog dog NN cord-023095-4dannjjm 5364 21 lifting lifting NN cord-023095-4dannjjm 5364 22 head head NN cord-023095-4dannjjm 5364 23 , , , cord-023095-4dannjjm 5364 24 dog dog NN cord-023095-4dannjjm 5364 25 attaining attain VBG cord-023095-4dannjjm 5364 26 sternal sternal JJ cord-023095-4dannjjm 5364 27 recumbency recumbency NN cord-023095-4dannjjm 5364 28 and and CC cord-023095-4dannjjm 5364 29 dog dog NN cord-023095-4dannjjm 5364 30 standing standing NN cord-023095-4dannjjm 5364 31 . . . cord-023095-4dannjjm 5365 1 Pulse pulse NN cord-023095-4dannjjm 5365 2 rate rate NN cord-023095-4dannjjm 5365 3 , , , cord-023095-4dannjjm 5365 4 respiratory respiratory JJ cord-023095-4dannjjm 5365 5 rate rate NN cord-023095-4dannjjm 5365 6 , , , cord-023095-4dannjjm 5365 7 SpO SpO NNP cord-023095-4dannjjm 5365 8 2 2 CD cord-023095-4dannjjm 5365 9 and and CC cord-023095-4dannjjm 5365 10 ETCO ETCO NNP cord-023095-4dannjjm 5365 11 2 2 CD cord-023095-4dannjjm 5365 12 were be VBD cord-023095-4dannjjm 5365 13 each each DT cord-023095-4dannjjm 5365 14 measured measure VBN cord-023095-4dannjjm 5365 15 every every DT cord-023095-4dannjjm 5365 16 5 5 CD cord-023095-4dannjjm 5365 17 min min NN cord-023095-4dannjjm 5365 18 . . . cord-023095-4dannjjm 5366 1 Within within IN cord-023095-4dannjjm 5366 2 - - HYPH cord-023095-4dannjjm 5366 3 dog dog NN cord-023095-4dannjjm 5366 4 comparisons comparison NNS cord-023095-4dannjjm 5366 5 were be VBD cord-023095-4dannjjm 5366 6 made make VBN cord-023095-4dannjjm 5366 7 using use VBG cord-023095-4dannjjm 5366 8 the the DT cord-023095-4dannjjm 5366 9 paired pair VBN cord-023095-4dannjjm 5366 10 Student Student NNP cord-023095-4dannjjm 5366 11 's 's POS cord-023095-4dannjjm 5366 12 t t NN cord-023095-4dannjjm 5366 13 - - HYPH cord-023095-4dannjjm 5366 14 test test NN cord-023095-4dannjjm 5366 15 . . . cord-023095-4dannjjm 5367 1 For for IN cord-023095-4dannjjm 5367 2 both both DT cord-023095-4dannjjm 5367 3 ALF ALF NNP cord-023095-4dannjjm 5367 4 and and CC cord-023095-4dannjjm 5367 5 PPF PPF NNP cord-023095-4dannjjm 5367 6 all all DT cord-023095-4dannjjm 5367 7 6 6 CD cord-023095-4dannjjm 5367 8 dogs dog NNS cord-023095-4dannjjm 5367 9 respired respire VBD cord-023095-4dannjjm 5367 10 voluntarily voluntarily RB cord-023095-4dannjjm 5367 11 at at IN cord-023095-4dannjjm 5367 12 the the DT cord-023095-4dannjjm 5367 13 labeled label VBN cord-023095-4dannjjm 5367 14 ( ( -LRB- cord-023095-4dannjjm 5367 15 1 1 CD cord-023095-4dannjjm 5367 16 X x NN cord-023095-4dannjjm 5367 17 ) ) -RRB- cord-023095-4dannjjm 5367 18 dose dose NN cord-023095-4dannjjm 5367 19 . . . cord-023095-4dannjjm 5368 1 For for IN cord-023095-4dannjjm 5368 2 PPF PPF NNP cord-023095-4dannjjm 5368 3 at at IN cord-023095-4dannjjm 5368 4 2 2 CD cord-023095-4dannjjm 5368 5 and and CC cord-023095-4dannjjm 5368 6 5 5 CD cord-023095-4dannjjm 5368 7 X X NNS cord-023095-4dannjjm 5368 8 doses dose NNS cord-023095-4dannjjm 5368 9 , , , cord-023095-4dannjjm 5368 10 4 4 CD cord-023095-4dannjjm 5368 11 and and CC cord-023095-4dannjjm 5368 12 0 0 CD cord-023095-4dannjjm 5368 13 dogs dog NNS cord-023095-4dannjjm 5368 14 respired respire VBD cord-023095-4dannjjm 5368 15 voluntarily voluntarily RB cord-023095-4dannjjm 5368 16 respectively respectively RB cord-023095-4dannjjm 5368 17 . . . cord-023095-4dannjjm 5369 1 For for IN cord-023095-4dannjjm 5369 2 ALF ALF NNP cord-023095-4dannjjm 5369 3 at at IN cord-023095-4dannjjm 5369 4 2 2 CD cord-023095-4dannjjm 5369 5 , , , cord-023095-4dannjjm 5369 6 5 5 CD cord-023095-4dannjjm 5369 7 and and CC cord-023095-4dannjjm 5369 8 10 10 CD cord-023095-4dannjjm 5370 1 X X NNS cord-023095-4dannjjm 5370 2 doses dose NNS cord-023095-4dannjjm 5370 3 , , , cord-023095-4dannjjm 5370 4 all all DT cord-023095-4dannjjm 5370 5 6 6 CD cord-023095-4dannjjm 5370 6 , , , cord-023095-4dannjjm 5370 7 4 4 CD cord-023095-4dannjjm 5370 8 and and CC cord-023095-4dannjjm 5370 9 1 1 CD cord-023095-4dannjjm 5370 10 dog dog NN cord-023095-4dannjjm 5370 11 respired respire VBD cord-023095-4dannjjm 5370 12 voluntarily voluntarily RB cord-023095-4dannjjm 5370 13 respectively respectively RB cord-023095-4dannjjm 5370 14 . . . cord-023095-4dannjjm 5371 1 For for IN cord-023095-4dannjjm 5371 2 all all DT cord-023095-4dannjjm 5371 3 six six CD cord-023095-4dannjjm 5371 4 dogs dog NNS cord-023095-4dannjjm 5371 5 to to TO cord-023095-4dannjjm 5371 6 become become VB cord-023095-4dannjjm 5371 7 apneic apneic JJ cord-023095-4dannjjm 5371 8 required require VBN cord-023095-4dannjjm 5371 9 5 5 CD cord-023095-4dannjjm 5371 10 X x NN cord-023095-4dannjjm 5371 11 dose dose NN cord-023095-4dannjjm 5371 12 of of IN cord-023095-4dannjjm 5371 13 PPF PPF NNP cord-023095-4dannjjm 5371 14 and and CC cord-023095-4dannjjm 5371 15 20 20 CD cord-023095-4dannjjm 5371 16 X x NN cord-023095-4dannjjm 5371 17 dose dose NN cord-023095-4dannjjm 5371 18 of of IN cord-023095-4dannjjm 5371 19 ALF ALF NNP cord-023095-4dannjjm 5371 20 . . . cord-023095-4dannjjm 5372 1 The the DT cord-023095-4dannjjm 5372 2 mean mean JJ cord-023095-4dannjjm 5372 3 no no DT cord-023095-4dannjjm 5372 4 observable observable JJ cord-023095-4dannjjm 5372 5 adverse adverse JJ cord-023095-4dannjjm 5372 6 effect effect NN cord-023095-4dannjjm 5372 7 dose dose NN cord-023095-4dannjjm 5372 8 ( ( -LRB- cord-023095-4dannjjm 5372 9 NOAEL NOAEL NNP cord-023095-4dannjjm 5372 10 ) ) -RRB- cord-023095-4dannjjm 5372 11 expressed express VBD cord-023095-4dannjjm 5372 12 as as IN cord-023095-4dannjjm 5372 13 a a DT cord-023095-4dannjjm 5372 14 multiple multiple NN cord-023095-4dannjjm 5372 15 of of IN cord-023095-4dannjjm 5372 16 the the DT cord-023095-4dannjjm 5372 17 labeled labeled JJ cord-023095-4dannjjm 5372 18 dose dose NN cord-023095-4dannjjm 5372 19 was be VBD cord-023095-4dannjjm 5372 20 higher high JJR cord-023095-4dannjjm 5372 21 for for IN cord-023095-4dannjjm 5372 22 ALF ALF NNP cord-023095-4dannjjm 5372 23 ( ( -LRB- cord-023095-4dannjjm 5372 24 4.8 4.8 CD cord-023095-4dannjjm 5372 25 X X NNS cord-023095-4dannjjm 5372 26 ) ) -RRB- cord-023095-4dannjjm 5372 27 than than IN cord-023095-4dannjjm 5372 28 for for IN cord-023095-4dannjjm 5372 29 PPF PPF NNP cord-023095-4dannjjm 5372 30 ( ( -LRB- cord-023095-4dannjjm 5372 31 1.7 1.7 CD cord-023095-4dannjjm 5372 32 X x NN cord-023095-4dannjjm 5372 33 ) ) -RRB- cord-023095-4dannjjm 5373 1 ( ( -LRB- cord-023095-4dannjjm 5373 2 p p NN cord-023095-4dannjjm 5373 3 5 5 CD cord-023095-4dannjjm 5373 4 0.035 0.035 CD cord-023095-4dannjjm 5373 5 ) ) -RRB- cord-023095-4dannjjm 5373 6 . . . cord-023095-4dannjjm 5374 1 There there EX cord-023095-4dannjjm 5374 2 were be VBD cord-023095-4dannjjm 5374 3 no no DT cord-023095-4dannjjm 5374 4 significant significant JJ cord-023095-4dannjjm 5374 5 differences difference NNS cord-023095-4dannjjm 5374 6 between between IN cord-023095-4dannjjm 5374 7 times time NNS cord-023095-4dannjjm 5374 8 to to IN cord-023095-4dannjjm 5374 9 extubation extubation NN cord-023095-4dannjjm 5374 10 , , , cord-023095-4dannjjm 5374 11 head head NN cord-023095-4dannjjm 5374 12 lift lift NN cord-023095-4dannjjm 5374 13 or or CC cord-023095-4dannjjm 5374 14 attaining attain VBG cord-023095-4dannjjm 5374 15 sternal sternal JJ cord-023095-4dannjjm 5374 16 recumbency recumbency NN cord-023095-4dannjjm 5374 17 after after IN cord-023095-4dannjjm 5374 18 ALF ALF NNP cord-023095-4dannjjm 5374 19 and and CC cord-023095-4dannjjm 5374 20 PPF PPF NNP cord-023095-4dannjjm 5374 21 at at IN cord-023095-4dannjjm 5374 22 1 1 CD cord-023095-4dannjjm 5374 23 , , , cord-023095-4dannjjm 5374 24 2 2 CD cord-023095-4dannjjm 5374 25 and and CC cord-023095-4dannjjm 5374 26 5 5 CD cord-023095-4dannjjm 5374 27 X X NNS cord-023095-4dannjjm 5374 28 doses dose NNS cord-023095-4dannjjm 5374 29 . . . cord-023095-4dannjjm 5375 1 At at IN cord-023095-4dannjjm 5375 2 the the DT cord-023095-4dannjjm 5375 3 2 2 CD cord-023095-4dannjjm 5375 4 X x NN cord-023095-4dannjjm 5375 5 dose dose NN cord-023095-4dannjjm 5375 6 , , , cord-023095-4dannjjm 5375 7 dogs dog NNS cord-023095-4dannjjm 5375 8 took take VBD cord-023095-4dannjjm 5375 9 longer long RBR cord-023095-4dannjjm 5375 10 to to TO cord-023095-4dannjjm 5375 11 stand stand VB cord-023095-4dannjjm 5375 12 after after IN cord-023095-4dannjjm 5375 13 ALF ALF NNP cord-023095-4dannjjm 5375 14 ( ( -LRB- cord-023095-4dannjjm 5375 15 29.0 29.0 CD cord-023095-4dannjjm 5375 16 AE AE NNP cord-023095-4dannjjm 5375 17 7.0 7.0 CD cord-023095-4dannjjm 5375 18 min min NNP cord-023095-4dannjjm 5375 19 ) ) -RRB- cord-023095-4dannjjm 5375 20 than than IN cord-023095-4dannjjm 5375 21 PPF PPF NNP cord-023095-4dannjjm 5375 22 ( ( -LRB- cord-023095-4dannjjm 5375 23 25.0 25.0 CD cord-023095-4dannjjm 5375 24 AE AE NNP cord-023095-4dannjjm 5375 25 8.3 8.3 CD cord-023095-4dannjjm 5375 26 min min NN cord-023095-4dannjjm 5375 27 ) ) -RRB- cord-023095-4dannjjm 5375 28 . . . cord-023095-4dannjjm 5376 1 We -PRON- PRP cord-023095-4dannjjm 5376 2 concluded conclude VBD cord-023095-4dannjjm 5376 3 that that IN cord-023095-4dannjjm 5376 4 based base VBN cord-023095-4dannjjm 5376 5 on on IN cord-023095-4dannjjm 5376 6 anaesthetic anaesthetic JJ cord-023095-4dannjjm 5376 7 duration duration NN cord-023095-4dannjjm 5376 8 , , , cord-023095-4dannjjm 5376 9 the the DT cord-023095-4dannjjm 5376 10 manufacturer manufacturer NN cord-023095-4dannjjm 5376 11 's 's POS cord-023095-4dannjjm 5376 12 labeled label VBN cord-023095-4dannjjm 5376 13 dose dose NN cord-023095-4dannjjm 5376 14 rates rate NNS cord-023095-4dannjjm 5376 15 of of IN cord-023095-4dannjjm 5376 16 2 2 CD cord-023095-4dannjjm 5376 17 mg mg NNP cord-023095-4dannjjm 5376 18 / / SYM cord-023095-4dannjjm 5376 19 kg kg NN cord-023095-4dannjjm 5376 20 for for IN cord-023095-4dannjjm 5376 21 ALF ALF NNP cord-023095-4dannjjm 5376 22 and and CC cord-023095-4dannjjm 5376 23 6.5 6.5 CD cord-023095-4dannjjm 5376 24 mg mg NNP cord-023095-4dannjjm 5376 25 / / SYM cord-023095-4dannjjm 5376 26 kg kg NNS cord-023095-4dannjjm 5376 27 for for IN cord-023095-4dannjjm 5376 28 PPF PPF NNP cord-023095-4dannjjm 5376 29 were be VBD cord-023095-4dannjjm 5376 30 equivalent equivalent JJ cord-023095-4dannjjm 5376 31 . . . cord-023095-4dannjjm 5377 1 However however RB cord-023095-4dannjjm 5377 2 , , , cord-023095-4dannjjm 5377 3 based base VBN cord-023095-4dannjjm 5377 4 on on IN cord-023095-4dannjjm 5377 5 the the DT cord-023095-4dannjjm 5377 6 dose dose NN cord-023095-4dannjjm 5377 7 escalation escalation NN cord-023095-4dannjjm 5377 8 , , , cord-023095-4dannjjm 5377 9 the the DT cord-023095-4dannjjm 5377 10 number number NN cord-023095-4dannjjm 5377 11 of of IN cord-023095-4dannjjm 5377 12 dogs dog NNS cord-023095-4dannjjm 5377 13 becoming become VBG cord-023095-4dannjjm 5377 14 apneic apneic JJ cord-023095-4dannjjm 5377 15 at at IN cord-023095-4dannjjm 5377 16 each each DT cord-023095-4dannjjm 5377 17 dose dose NN cord-023095-4dannjjm 5377 18 - - HYPH cord-023095-4dannjjm 5377 19 multiple multiple NN cord-023095-4dannjjm 5377 20 is be VBZ cord-023095-4dannjjm 5377 21 consistent consistent JJ cord-023095-4dannjjm 5377 22 with with IN cord-023095-4dannjjm 5377 23 PPF PPF NNP cord-023095-4dannjjm 5377 24 having have VBG cord-023095-4dannjjm 5377 25 a a DT cord-023095-4dannjjm 5377 26 narrower narrow JJR cord-023095-4dannjjm 5377 27 safety safety NN cord-023095-4dannjjm 5377 28 margin margin NN cord-023095-4dannjjm 5377 29 , , , cord-023095-4dannjjm 5377 30 i.e. i.e. FW cord-023095-4dannjjm 5377 31 , , , cord-023095-4dannjjm 5377 32 PPF PPF NNP cord-023095-4dannjjm 5377 33 caused cause VBD cord-023095-4dannjjm 5377 34 more more JJR cord-023095-4dannjjm 5377 35 respiratory respiratory JJ cord-023095-4dannjjm 5377 36 depression depression NN cord-023095-4dannjjm 5377 37 than than IN cord-023095-4dannjjm 5377 38 ALF ALF NNP cord-023095-4dannjjm 5377 39 . . . cord-023095-4dannjjm 5378 1 Parenteral parenteral JJ cord-023095-4dannjjm 5378 2 levetiracetam levetiracetam NNS cord-023095-4dannjjm 5378 3 ( ( -LRB- cord-023095-4dannjjm 5378 4 LEV LEV NNP cord-023095-4dannjjm 5378 5 ) ) -RRB- cord-023095-4dannjjm 5378 6 has have VBZ cord-023095-4dannjjm 5378 7 been be VBN cord-023095-4dannjjm 5378 8 shown show VBN cord-023095-4dannjjm 5378 9 to to TO cord-023095-4dannjjm 5378 10 rapidly rapidly RB cord-023095-4dannjjm 5378 11 attain attain VB cord-023095-4dannjjm 5378 12 therapeutic therapeutic JJ cord-023095-4dannjjm 5378 13 levels level NNS cord-023095-4dannjjm 5378 14 in in IN cord-023095-4dannjjm 5378 15 dogs dog NNS cord-023095-4dannjjm 5378 16 when when WRB cord-023095-4dannjjm 5378 17 given give VBN cord-023095-4dannjjm 5378 18 IV IV NNP cord-023095-4dannjjm 5378 19 or or CC cord-023095-4dannjjm 5378 20 IM IM NNP cord-023095-4dannjjm 5378 21 , , , cord-023095-4dannjjm 5378 22 and and CC cord-023095-4dannjjm 5378 23 has have VBZ cord-023095-4dannjjm 5378 24 been be VBN cord-023095-4dannjjm 5378 25 used use VBN cord-023095-4dannjjm 5378 26 offlabel offlabel NN cord-023095-4dannjjm 5378 27 for for IN cord-023095-4dannjjm 5378 28 the the DT cord-023095-4dannjjm 5378 29 treatment treatment NN cord-023095-4dannjjm 5378 30 of of IN cord-023095-4dannjjm 5378 31 seizure seizure NN cord-023095-4dannjjm 5378 32 emergencies emergency NNS cord-023095-4dannjjm 5378 33 . . . cord-023095-4dannjjm 5379 1 The the DT cord-023095-4dannjjm 5379 2 purpose purpose NN cord-023095-4dannjjm 5379 3 of of IN cord-023095-4dannjjm 5379 4 this this DT cord-023095-4dannjjm 5379 5 study study NN cord-023095-4dannjjm 5379 6 was be VBD cord-023095-4dannjjm 5379 7 to to TO cord-023095-4dannjjm 5379 8 determine determine VB cord-023095-4dannjjm 5379 9 the the DT cord-023095-4dannjjm 5379 10 safety safety NN cord-023095-4dannjjm 5379 11 and and CC cord-023095-4dannjjm 5379 12 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 5379 13 of of IN cord-023095-4dannjjm 5379 14 subcutaneously subcutaneously RB cord-023095-4dannjjm 5379 15 administered administer VBN cord-023095-4dannjjm 5379 16 levetiracetam levetiracetam NNS cord-023095-4dannjjm 5379 17 in in IN cord-023095-4dannjjm 5379 18 healthy healthy JJ cord-023095-4dannjjm 5379 19 dogs dog NNS cord-023095-4dannjjm 5379 20 . . . cord-023095-4dannjjm 5380 1 Potential potential JJ cord-023095-4dannjjm 5380 2 application application NN cord-023095-4dannjjm 5380 3 of of IN cord-023095-4dannjjm 5380 4 these these DT cord-023095-4dannjjm 5380 5 results result NNS cord-023095-4dannjjm 5380 6 would would MD cord-023095-4dannjjm 5380 7 be be VB cord-023095-4dannjjm 5380 8 use use NN cord-023095-4dannjjm 5380 9 of of IN cord-023095-4dannjjm 5380 10 SQ SQ NNP cord-023095-4dannjjm 5380 11 LEV LEV NNP cord-023095-4dannjjm 5380 12 instead instead RB cord-023095-4dannjjm 5380 13 of of IN cord-023095-4dannjjm 5380 14 or or CC cord-023095-4dannjjm 5380 15 in in IN cord-023095-4dannjjm 5380 16 addition addition NN cord-023095-4dannjjm 5380 17 to to IN cord-023095-4dannjjm 5380 18 rectal rectal JJ cord-023095-4dannjjm 5380 19 diazepam diazepam NN cord-023095-4dannjjm 5380 20 for for IN cord-023095-4dannjjm 5380 21 the the DT cord-023095-4dannjjm 5380 22 treatment treatment NN cord-023095-4dannjjm 5380 23 of of IN cord-023095-4dannjjm 5380 24 cluster cluster NN cord-023095-4dannjjm 5380 25 seizures seizure NNS cord-023095-4dannjjm 5380 26 at at IN cord-023095-4dannjjm 5380 27 home home NN cord-023095-4dannjjm 5380 28 . . . cord-023095-4dannjjm 5381 1 LEV LEV NNP cord-023095-4dannjjm 5381 2 was be VBD cord-023095-4dannjjm 5381 3 administered administer VBN cord-023095-4dannjjm 5381 4 SQ SQ NNP cord-023095-4dannjjm 5381 5 between between IN cord-023095-4dannjjm 5381 6 the the DT cord-023095-4dannjjm 5381 7 shoulder shoulder NN cord-023095-4dannjjm 5381 8 blades blade NNS cord-023095-4dannjjm 5381 9 to to IN cord-023095-4dannjjm 5381 10 4 4 CD cord-023095-4dannjjm 5381 11 healthy healthy JJ cord-023095-4dannjjm 5381 12 , , , cord-023095-4dannjjm 5381 13 purpose purpose NN cord-023095-4dannjjm 5381 14 - - HYPH cord-023095-4dannjjm 5381 15 bred breed VBN cord-023095-4dannjjm 5381 16 hound hound NN cord-023095-4dannjjm 5381 17 dogs dog NNS cord-023095-4dannjjm 5381 18 , , , cord-023095-4dannjjm 5381 19 at at IN cord-023095-4dannjjm 5381 20 a a DT cord-023095-4dannjjm 5381 21 dose dose NN cord-023095-4dannjjm 5381 22 of of IN cord-023095-4dannjjm 5381 23 60 60 CD cord-023095-4dannjjm 5381 24 mg mg NN cord-023095-4dannjjm 5381 25 / / SYM cord-023095-4dannjjm 5381 26 kg kg NN cord-023095-4dannjjm 5381 27 ( ( -LRB- cord-023095-4dannjjm 5381 28 undiluted undiluted JJ cord-023095-4dannjjm 5381 29 ) ) -RRB- cord-023095-4dannjjm 5381 30 . . . cord-023095-4dannjjm 5382 1 Blood blood NN cord-023095-4dannjjm 5382 2 samples sample NNS cord-023095-4dannjjm 5382 3 were be VBD cord-023095-4dannjjm 5382 4 collected collect VBN cord-023095-4dannjjm 5382 5 at at IN cord-023095-4dannjjm 5382 6 15 15 CD cord-023095-4dannjjm 5382 7 , , , cord-023095-4dannjjm 5382 8 120 120 CD cord-023095-4dannjjm 5382 9 and and CC cord-023095-4dannjjm 5382 10 420 420 CD cord-023095-4dannjjm 5382 11 minutes minute NNS cord-023095-4dannjjm 5382 12 after after IN cord-023095-4dannjjm 5382 13 LEV LEV NNP cord-023095-4dannjjm 5382 14 administration administration NN cord-023095-4dannjjm 5382 15 via via IN cord-023095-4dannjjm 5382 16 jugular jugular NN cord-023095-4dannjjm 5382 17 venipuncture venipuncture NN cord-023095-4dannjjm 5382 18 . . . cord-023095-4dannjjm 5383 1 Plasma plasma NN cord-023095-4dannjjm 5383 2 LEV LEV NNP cord-023095-4dannjjm 5383 3 concentrations concentration NNS cord-023095-4dannjjm 5383 4 were be VBD cord-023095-4dannjjm 5383 5 measured measure VBN cord-023095-4dannjjm 5383 6 by by IN cord-023095-4dannjjm 5383 7 high high JJ cord-023095-4dannjjm 5383 8 pressure pressure NN cord-023095-4dannjjm 5383 9 liquid liquid NN cord-023095-4dannjjm 5383 10 chromatography chromatography NN cord-023095-4dannjjm 5383 11 . . . cord-023095-4dannjjm 5384 1 None none NN cord-023095-4dannjjm 5384 2 of of IN cord-023095-4dannjjm 5384 3 the the DT cord-023095-4dannjjm 5384 4 dogs dog NNS cord-023095-4dannjjm 5384 5 became become VBD cord-023095-4dannjjm 5384 6 sedated sedate VBN cord-023095-4dannjjm 5384 7 , , , cord-023095-4dannjjm 5384 8 nor nor CC cord-023095-4dannjjm 5384 9 was be VBD cord-023095-4dannjjm 5384 10 there there EX cord-023095-4dannjjm 5384 11 pain pain NN cord-023095-4dannjjm 5384 12 evident evident JJ cord-023095-4dannjjm 5384 13 on on IN cord-023095-4dannjjm 5384 14 palpation palpation NN cord-023095-4dannjjm 5384 15 of of IN cord-023095-4dannjjm 5384 16 the the DT cord-023095-4dannjjm 5384 17 injection injection NN cord-023095-4dannjjm 5384 18 site site NN cord-023095-4dannjjm 5384 19 . . . cord-023095-4dannjjm 5385 1 Mean mean JJ cord-023095-4dannjjm 5385 2 ( ( -LRB- cord-023095-4dannjjm 5385 3 standard standard JJ cord-023095-4dannjjm 5385 4 deviation deviation NN cord-023095-4dannjjm 5385 5 ) ) -RRB- cord-023095-4dannjjm 5386 1 LEV LEV NNP cord-023095-4dannjjm 5386 2 concentration concentration NN cord-023095-4dannjjm 5386 3 was be VBD cord-023095-4dannjjm 5386 4 65.2 65.2 CD cord-023095-4dannjjm 5386 5 ( ( -LRB- cord-023095-4dannjjm 5386 6 29.5 29.5 CD cord-023095-4dannjjm 5386 7 ) ) -RRB- cord-023095-4dannjjm 5386 8 , , , cord-023095-4dannjjm 5386 9 114.5 114.5 CD cord-023095-4dannjjm 5386 10 ( ( -LRB- cord-023095-4dannjjm 5386 11 10.5 10.5 CD cord-023095-4dannjjm 5386 12 ) ) -RRB- cord-023095-4dannjjm 5386 13 and and CC cord-023095-4dannjjm 5386 14 84.9 84.9 CD cord-023095-4dannjjm 5386 15 ( ( -LRB- cord-023095-4dannjjm 5386 16 20.6 20.6 CD cord-023095-4dannjjm 5386 17 ) ) -RRB- cord-023095-4dannjjm 5387 1 mg mg NNP cord-023095-4dannjjm 5387 2 / / SYM cord-023095-4dannjjm 5387 3 ml ml XX cord-023095-4dannjjm 5387 4 at at IN cord-023095-4dannjjm 5387 5 15 15 CD cord-023095-4dannjjm 5387 6 , , , cord-023095-4dannjjm 5387 7 120 120 CD cord-023095-4dannjjm 5387 8 and and CC cord-023095-4dannjjm 5387 9 420 420 CD cord-023095-4dannjjm 5387 10 minutes minute NNS cord-023095-4dannjjm 5387 11 , , , cord-023095-4dannjjm 5387 12 respectively respectively RB cord-023095-4dannjjm 5387 13 . . . cord-023095-4dannjjm 5388 1 Administration Administration NNP cord-023095-4dannjjm 5388 2 of of IN cord-023095-4dannjjm 5388 3 SQ SQ NNP cord-023095-4dannjjm 5388 4 LEV LEV NNP cord-023095-4dannjjm 5388 5 was be VBD cord-023095-4dannjjm 5388 6 well well RB cord-023095-4dannjjm 5388 7 tolerated tolerate VBN cord-023095-4dannjjm 5388 8 , , , cord-023095-4dannjjm 5388 9 and and CC cord-023095-4dannjjm 5388 10 exceeded exceed VBD cord-023095-4dannjjm 5388 11 the the DT cord-023095-4dannjjm 5388 12 suggested suggest VBN cord-023095-4dannjjm 5388 13 therapeutic therapeutic JJ cord-023095-4dannjjm 5388 14 range range NN cord-023095-4dannjjm 5388 15 ( ( -LRB- cord-023095-4dannjjm 5388 16 5 5 CD cord-023095-4dannjjm 5388 17 - - SYM cord-023095-4dannjjm 5388 18 45 45 CD cord-023095-4dannjjm 5388 19 mg mg NNP cord-023095-4dannjjm 5388 20 / / SYM cord-023095-4dannjjm 5388 21 ml ml NNP cord-023095-4dannjjm 5388 22 ) ) -RRB- cord-023095-4dannjjm 5388 23 within within IN cord-023095-4dannjjm 5388 24 15 15 CD cord-023095-4dannjjm 5388 25 minutes minute NNS cord-023095-4dannjjm 5388 26 of of IN cord-023095-4dannjjm 5388 27 administration administration NN cord-023095-4dannjjm 5388 28 , , , cord-023095-4dannjjm 5388 29 and and CC cord-023095-4dannjjm 5388 30 remained remain VBD cord-023095-4dannjjm 5388 31 above above IN cord-023095-4dannjjm 5388 32 the the DT cord-023095-4dannjjm 5388 33 range range NN cord-023095-4dannjjm 5388 34 for for IN cord-023095-4dannjjm 5388 35 at at RB cord-023095-4dannjjm 5388 36 least least RBS cord-023095-4dannjjm 5388 37 7 7 CD cord-023095-4dannjjm 5388 38 hours hour NNS cord-023095-4dannjjm 5388 39 . . . cord-023095-4dannjjm 5389 1 These these DT cord-023095-4dannjjm 5389 2 data datum NNS cord-023095-4dannjjm 5389 3 indicate indicate VBP cord-023095-4dannjjm 5389 4 that that IN cord-023095-4dannjjm 5389 5 SQ SQ NNP cord-023095-4dannjjm 5389 6 LEV LEV NNP cord-023095-4dannjjm 5389 7 administration administration NN cord-023095-4dannjjm 5389 8 may may MD cord-023095-4dannjjm 5389 9 be be VB cord-023095-4dannjjm 5389 10 an an DT cord-023095-4dannjjm 5389 11 alternative alternative NN cord-023095-4dannjjm 5389 12 for for IN cord-023095-4dannjjm 5389 13 the the DT cord-023095-4dannjjm 5389 14 at at IN cord-023095-4dannjjm 5389 15 - - HYPH cord-023095-4dannjjm 5389 16 home home NN cord-023095-4dannjjm 5389 17 treatment treatment NN cord-023095-4dannjjm 5389 18 of of IN cord-023095-4dannjjm 5389 19 cluster cluster NN cord-023095-4dannjjm 5389 20 seizures seizure NNS cord-023095-4dannjjm 5389 21 in in IN cord-023095-4dannjjm 5389 22 dogs dog NNS cord-023095-4dannjjm 5389 23 , , , cord-023095-4dannjjm 5389 24 and and CC cord-023095-4dannjjm 5389 25 prospective prospective JJ cord-023095-4dannjjm 5389 26 studies study NNS cord-023095-4dannjjm 5389 27 in in IN cord-023095-4dannjjm 5389 28 epileptic epileptic JJ cord-023095-4dannjjm 5389 29 dogs dog NNS cord-023095-4dannjjm 5389 30 are be VBP cord-023095-4dannjjm 5389 31 warranted warrant VBN cord-023095-4dannjjm 5389 32 . . . cord-023095-4dannjjm 5390 1 The the DT cord-023095-4dannjjm 5390 2 purpose purpose NN cord-023095-4dannjjm 5390 3 of of IN cord-023095-4dannjjm 5390 4 this this DT cord-023095-4dannjjm 5390 5 study study NN cord-023095-4dannjjm 5390 6 was be VBD cord-023095-4dannjjm 5390 7 to to TO cord-023095-4dannjjm 5390 8 assess assess VB cord-023095-4dannjjm 5390 9 the the DT cord-023095-4dannjjm 5390 10 effects effect NNS cord-023095-4dannjjm 5390 11 of of IN cord-023095-4dannjjm 5390 12 CYP CYP NNP cord-023095-4dannjjm 5390 13 inhibitors inhibitor NNS cord-023095-4dannjjm 5390 14 ( ( -LRB- cord-023095-4dannjjm 5390 15 ketoconazole ketoconazole NNP cord-023095-4dannjjm 5390 16 , , , cord-023095-4dannjjm 5390 17 chloramphenicol chloramphenicol NN cord-023095-4dannjjm 5390 18 , , , cord-023095-4dannjjm 5390 19 fluoxetine fluoxetine NN cord-023095-4dannjjm 5390 20 , , , cord-023095-4dannjjm 5390 21 trimethoprim trimethoprim NNP cord-023095-4dannjjm 5390 22 , , , cord-023095-4dannjjm 5390 23 cimetidine cimetidine NN cord-023095-4dannjjm 5390 24 , , , cord-023095-4dannjjm 5390 25 and and CC cord-023095-4dannjjm 5390 26 medetomidine medetomidine NNP cord-023095-4dannjjm 5390 27 ) ) -RRB- cord-023095-4dannjjm 5390 28 in in IN cord-023095-4dannjjm 5390 29 varying vary VBG cord-023095-4dannjjm 5390 30 combinations combination NNS cord-023095-4dannjjm 5390 31 on on IN cord-023095-4dannjjm 5390 32 the the DT cord-023095-4dannjjm 5390 33 bioavailability bioavailability NN cord-023095-4dannjjm 5390 34 of of IN cord-023095-4dannjjm 5390 35 oral oral JJ cord-023095-4dannjjm 5390 36 methadone methadone NN cord-023095-4dannjjm 5390 37 in in IN cord-023095-4dannjjm 5390 38 healthy healthy JJ cord-023095-4dannjjm 5390 39 Greyhound Greyhound NNP cord-023095-4dannjjm 5390 40 dogs dog NNS cord-023095-4dannjjm 5390 41 . . . cord-023095-4dannjjm 5391 1 The the DT cord-023095-4dannjjm 5391 2 IACUC IACUC NNP cord-023095-4dannjjm 5391 3 approved approve VBD cord-023095-4dannjjm 5391 4 this this DT cord-023095-4dannjjm 5391 5 study study NN cord-023095-4dannjjm 5391 6 . . . cord-023095-4dannjjm 5392 1 CYP CYP NNP cord-023095-4dannjjm 5392 2 inhibitors inhibitor NNS cord-023095-4dannjjm 5392 3 were be VBD cord-023095-4dannjjm 5392 4 administered administer VBN cord-023095-4dannjjm 5392 5 PO PO NNP cord-023095-4dannjjm 5392 6 for for IN cord-023095-4dannjjm 5392 7 48 48 CD cord-023095-4dannjjm 5392 8 hours hour NNS cord-023095-4dannjjm 5392 9 prior prior RB cord-023095-4dannjjm 5392 10 to to IN cord-023095-4dannjjm 5392 11 methadone methadone NNP cord-023095-4dannjjm 5392 12 administration administration NNP cord-023095-4dannjjm 5392 13 . . . cord-023095-4dannjjm 5393 1 Methadone Methadone NNP cord-023095-4dannjjm 5393 2 hydrochloride hydrochloride NN cord-023095-4dannjjm 5393 3 was be VBD cord-023095-4dannjjm 5393 4 administered administer VBN cord-023095-4dannjjm 5393 5 PO PO NNP cord-023095-4dannjjm 5393 6 at at IN cord-023095-4dannjjm 5393 7 a a DT cord-023095-4dannjjm 5393 8 targeted targeted JJ cord-023095-4dannjjm 5393 9 dose dose NN cord-023095-4dannjjm 5393 10 of of IN cord-023095-4dannjjm 5393 11 1 1 CD cord-023095-4dannjjm 5393 12 mg mg NNP cord-023095-4dannjjm 5393 13 / / SYM cord-023095-4dannjjm 5393 14 kg kg NNP cord-023095-4dannjjm 5393 15 . . . cord-023095-4dannjjm 5394 1 Blood blood NN cord-023095-4dannjjm 5394 2 was be VBD cord-023095-4dannjjm 5394 3 obtained obtain VBN cord-023095-4dannjjm 5394 4 for for IN cord-023095-4dannjjm 5394 5 the the DT cord-023095-4dannjjm 5394 6 determination determination NN cord-023095-4dannjjm 5394 7 of of IN cord-023095-4dannjjm 5394 8 methadone methadone NN cord-023095-4dannjjm 5394 9 plasma plasma NN cord-023095-4dannjjm 5394 10 concentrations concentration NNS cord-023095-4dannjjm 5394 11 by by IN cord-023095-4dannjjm 5394 12 mass mass NN cord-023095-4dannjjm 5394 13 spectrometry spectrometry NN cord-023095-4dannjjm 5394 14 . . . cord-023095-4dannjjm 5395 1 The the DT cord-023095-4dannjjm 5395 2 area area NN cord-023095-4dannjjm 5395 3 under under IN cord-023095-4dannjjm 5395 4 the the DT cord-023095-4dannjjm 5395 5 curve curve NN cord-023095-4dannjjm 5395 6 ( ( -LRB- cord-023095-4dannjjm 5395 7 AUC AUC NNP cord-023095-4dannjjm 5395 8 ) ) -RRB- cord-023095-4dannjjm 5395 9 of of IN cord-023095-4dannjjm 5395 10 methadone methadone NN cord-023095-4dannjjm 5395 11 for for IN cord-023095-4dannjjm 5395 12 each each DT cord-023095-4dannjjm 5395 13 treatment treatment NN cord-023095-4dannjjm 5395 14 group group NN cord-023095-4dannjjm 5395 15 was be VBD cord-023095-4dannjjm 5395 16 compared compare VBN cord-023095-4dannjjm 5395 17 statistically statistically RB cord-023095-4dannjjm 5395 18 to to IN cord-023095-4dannjjm 5395 19 the the DT cord-023095-4dannjjm 5395 20 AUC AUC NNP cord-023095-4dannjjm 5395 21 of of IN cord-023095-4dannjjm 5395 22 methadone methadone NN cord-023095-4dannjjm 5395 23 administered administer VBN cord-023095-4dannjjm 5395 24 without without IN cord-023095-4dannjjm 5395 25 inhibitors inhibitor NNS cord-023095-4dannjjm 5395 26 using use VBG cord-023095-4dannjjm 5395 27 the the DT cord-023095-4dannjjm 5395 28 Mann Mann NNP cord-023095-4dannjjm 5395 29 - - HYPH cord-023095-4dannjjm 5395 30 Whitney Whitney NNP cord-023095-4dannjjm 5395 31 Rank Rank NNP cord-023095-4dannjjm 5395 32 Sum Sum NNP cord-023095-4dannjjm 5395 33 Test Test NNP cord-023095-4dannjjm 5395 34 . . . cord-023095-4dannjjm 5396 1 Significant significant JJ cord-023095-4dannjjm 5396 2 increases increase NNS cord-023095-4dannjjm 5396 3 ( ( -LRB- cord-023095-4dannjjm 5396 4 P p NN cord-023095-4dannjjm 5396 5 o o NN cord-023095-4dannjjm 5396 6 0.001 0.001 CD cord-023095-4dannjjm 5396 7 ) ) -RRB- cord-023095-4dannjjm 5396 8 in in IN cord-023095-4dannjjm 5396 9 the the DT cord-023095-4dannjjm 5396 10 methadone methadone NN cord-023095-4dannjjm 5397 1 AUC AUC NNP cord-023095-4dannjjm 5397 2 occurred occur VBD cord-023095-4dannjjm 5397 3 in in IN cord-023095-4dannjjm 5397 4 all all DT cord-023095-4dannjjm 5397 5 treatment treatment NN cord-023095-4dannjjm 5397 6 groups group NNS cord-023095-4dannjjm 5397 7 which which WDT cord-023095-4dannjjm 5397 8 included include VBD cord-023095-4dannjjm 5397 9 chloramphenicol chloramphenicol NN cord-023095-4dannjjm 5397 10 , , , cord-023095-4dannjjm 5397 11 including include VBG cord-023095-4dannjjm 5397 12 chloramphenicol chloramphenicol NNP cord-023095-4dannjjm 5397 13 as as IN cord-023095-4dannjjm 5397 14 the the DT cord-023095-4dannjjm 5397 15 only only JJ cord-023095-4dannjjm 5397 16 inhibitor inhibitor NN cord-023095-4dannjjm 5397 17 . . . cord-023095-4dannjjm 5398 1 The the DT cord-023095-4dannjjm 5398 2 magnitude magnitude NN cord-023095-4dannjjm 5398 3 of of IN cord-023095-4dannjjm 5398 4 increase increase NN cord-023095-4dannjjm 5398 5 was be VBD cord-023095-4dannjjm 5398 6 at at RB cord-023095-4dannjjm 5398 7 least least JJS cord-023095-4dannjjm 5398 8 50 50 CD cord-023095-4dannjjm 5398 9 fold fold NN cord-023095-4dannjjm 5398 10 . . . cord-023095-4dannjjm 5399 1 Mean mean JJ cord-023095-4dannjjm 5399 2 concentrations concentration NNS cord-023095-4dannjjm 5399 3 of of IN cord-023095-4dannjjm 5399 4 methadone methadone NN cord-023095-4dannjjm 5399 5 exceeded exceed VBD cord-023095-4dannjjm 5399 6 10 10 CD cord-023095-4dannjjm 5399 7 ng ng NN cord-023095-4dannjjm 5399 8 / / SYM cord-023095-4dannjjm 5399 9 mL ml NN cord-023095-4dannjjm 5399 10 for for IN cord-023095-4dannjjm 5399 11 at at RB cord-023095-4dannjjm 5399 12 least least RBS cord-023095-4dannjjm 5399 13 10 10 CD cord-023095-4dannjjm 5399 14 hours hour NNS cord-023095-4dannjjm 5399 15 in in IN cord-023095-4dannjjm 5399 16 all all DT cord-023095-4dannjjm 5399 17 groups group NNS cord-023095-4dannjjm 5399 18 administered administer VBD cord-023095-4dannjjm 5399 19 concurrent concurrent JJ cord-023095-4dannjjm 5399 20 chloramphenicol chloramphenicol NN cord-023095-4dannjjm 5399 21 . . . cord-023095-4dannjjm 5400 1 No no DT cord-023095-4dannjjm 5400 2 significant significant JJ cord-023095-4dannjjm 5400 3 increases increase NNS cord-023095-4dannjjm 5400 4 in in IN cord-023095-4dannjjm 5400 5 the the DT cord-023095-4dannjjm 5400 6 AUC AUC NNP cord-023095-4dannjjm 5400 7 occurred occur VBD cord-023095-4dannjjm 5400 8 in in IN cord-023095-4dannjjm 5400 9 any any DT cord-023095-4dannjjm 5400 10 of of IN cord-023095-4dannjjm 5400 11 the the DT cord-023095-4dannjjm 5400 12 groups group NNS cord-023095-4dannjjm 5400 13 which which WDT cord-023095-4dannjjm 5400 14 did do VBD cord-023095-4dannjjm 5400 15 not not RB cord-023095-4dannjjm 5400 16 include include VB cord-023095-4dannjjm 5400 17 chloramphenicol chloramphenicol NN cord-023095-4dannjjm 5400 18 . . . cord-023095-4dannjjm 5401 1 In in IN cord-023095-4dannjjm 5401 2 conclusion conclusion NN cord-023095-4dannjjm 5401 3 , , , cord-023095-4dannjjm 5401 4 chloramphenicol chloramphenicol NN cord-023095-4dannjjm 5401 5 significantly significantly RB cord-023095-4dannjjm 5401 6 inhibits inhibit VBZ cord-023095-4dannjjm 5401 7 the the DT cord-023095-4dannjjm 5401 8 metabolism metabolism NN cord-023095-4dannjjm 5401 9 of of IN cord-023095-4dannjjm 5401 10 methadone methadone NN cord-023095-4dannjjm 5401 11 in in IN cord-023095-4dannjjm 5401 12 Greyhound Greyhound NNP cord-023095-4dannjjm 5401 13 dogs dog NNS cord-023095-4dannjjm 5401 14 . . . cord-023095-4dannjjm 5402 1 As as IN cord-023095-4dannjjm 5402 2 a a DT cord-023095-4dannjjm 5402 3 result result NN cord-023095-4dannjjm 5402 4 , , , cord-023095-4dannjjm 5402 5 the the DT cord-023095-4dannjjm 5402 6 oral oral JJ cord-023095-4dannjjm 5402 7 bioavailability bioavailability NN cord-023095-4dannjjm 5402 8 of of IN cord-023095-4dannjjm 5402 9 methadone methadone NN cord-023095-4dannjjm 5402 10 is be VBZ cord-023095-4dannjjm 5402 11 significantly significantly RB cord-023095-4dannjjm 5402 12 increased increase VBN cord-023095-4dannjjm 5402 13 and and CC cord-023095-4dannjjm 5402 14 plasma plasma NN cord-023095-4dannjjm 5402 15 concentrations concentration NNS cord-023095-4dannjjm 5402 16 are be VBP cord-023095-4dannjjm 5402 17 achieved achieve VBN cord-023095-4dannjjm 5402 18 that that WDT cord-023095-4dannjjm 5402 19 are be VBP cord-023095-4dannjjm 5402 20 reported report VBN cord-023095-4dannjjm 5402 21 to to TO cord-023095-4dannjjm 5402 22 be be VB cord-023095-4dannjjm 5402 23 effective effective JJ cord-023095-4dannjjm 5402 24 in in IN cord-023095-4dannjjm 5402 25 humans human NNS cord-023095-4dannjjm 5402 26 for for IN cord-023095-4dannjjm 5402 27 10 10 CD cord-023095-4dannjjm 5402 28 - - SYM cord-023095-4dannjjm 5402 29 36 36 CD cord-023095-4dannjjm 5402 30 hours hour NNS cord-023095-4dannjjm 5402 31 after after IN cord-023095-4dannjjm 5402 32 a a DT cord-023095-4dannjjm 5402 33 single single JJ cord-023095-4dannjjm 5402 34 oral oral JJ cord-023095-4dannjjm 5402 35 administration administration NN cord-023095-4dannjjm 5402 36 . . . cord-023095-4dannjjm 5403 1 Doxycycline Doxycycline NNP cord-023095-4dannjjm 5403 2 hyclate hyclate NNP cord-023095-4dannjjm 5403 3 is be VBZ cord-023095-4dannjjm 5403 4 used use VBN cord-023095-4dannjjm 5403 5 frequently frequently RB cord-023095-4dannjjm 5403 6 in in IN cord-023095-4dannjjm 5403 7 small small JJ cord-023095-4dannjjm 5403 8 animals animal NNS cord-023095-4dannjjm 5403 9 , , , cord-023095-4dannjjm 5403 10 horses horse NNS cord-023095-4dannjjm 5403 11 and and CC cord-023095-4dannjjm 5403 12 exotic exotic JJ cord-023095-4dannjjm 5403 13 animals animal NNS cord-023095-4dannjjm 5403 14 for for IN cord-023095-4dannjjm 5403 15 treatment treatment NN cord-023095-4dannjjm 5403 16 of of IN cord-023095-4dannjjm 5403 17 a a DT cord-023095-4dannjjm 5403 18 wide wide JJ cord-023095-4dannjjm 5403 19 variety variety NN cord-023095-4dannjjm 5403 20 of of IN cord-023095-4dannjjm 5403 21 infections infection NNS cord-023095-4dannjjm 5403 22 . . . cord-023095-4dannjjm 5404 1 Because because IN cord-023095-4dannjjm 5404 2 doxycycline doxycycline NNP cord-023095-4dannjjm 5404 3 hyclate hyclate NNP cord-023095-4dannjjm 5404 4 tablets tablet NNS cord-023095-4dannjjm 5404 5 may may MD cord-023095-4dannjjm 5404 6 not not RB cord-023095-4dannjjm 5404 7 be be VB cord-023095-4dannjjm 5404 8 suitable suitable JJ cord-023095-4dannjjm 5404 9 for for IN cord-023095-4dannjjm 5404 10 oral oral JJ cord-023095-4dannjjm 5404 11 administration administration NN cord-023095-4dannjjm 5404 12 in in IN cord-023095-4dannjjm 5404 13 some some DT cord-023095-4dannjjm 5404 14 animals animal NNS cord-023095-4dannjjm 5404 15 , , , cord-023095-4dannjjm 5404 16 particularly particularly RB cord-023095-4dannjjm 5404 17 horses horse NNS cord-023095-4dannjjm 5404 18 and and CC cord-023095-4dannjjm 5404 19 cats cat NNS cord-023095-4dannjjm 5404 20 , , , cord-023095-4dannjjm 5404 21 it -PRON- PRP cord-023095-4dannjjm 5404 22 has have VBZ cord-023095-4dannjjm 5404 23 been be VBN cord-023095-4dannjjm 5404 24 compounded compound VBN cord-023095-4dannjjm 5404 25 into into IN cord-023095-4dannjjm 5404 26 liquid liquid JJ cord-023095-4dannjjm 5404 27 suspensions suspension NNS cord-023095-4dannjjm 5404 28 . . . cord-023095-4dannjjm 5405 1 The the DT cord-023095-4dannjjm 5405 2 commercially commercially RB cord-023095-4dannjjm 5405 3 available available JJ cord-023095-4dannjjm 5405 4 doxycycline doxycycline NN cord-023095-4dannjjm 5405 5 calcium calcium NN cord-023095-4dannjjm 5405 6 10 10 CD cord-023095-4dannjjm 5406 1 mg mg NNP cord-023095-4dannjjm 5406 2 / / SYM cord-023095-4dannjjm 5406 3 ml ml CC cord-023095-4dannjjm 5406 4 oral oral JJ cord-023095-4dannjjm 5406 5 suspension suspension NN cord-023095-4dannjjm 5407 1 , , , cord-023095-4dannjjm 5407 2 Vibramycin Vibramycin NNP cord-023095-4dannjjm 5407 3 s s POS cord-023095-4dannjjm 5407 4 ( ( -LRB- cord-023095-4dannjjm 5407 5 Pfizer Pfizer NNP cord-023095-4dannjjm 5407 6 ) ) -RRB- cord-023095-4dannjjm 5407 7 is be VBZ cord-023095-4dannjjm 5407 8 not not RB cord-023095-4dannjjm 5407 9 suitable suitable JJ cord-023095-4dannjjm 5407 10 for for IN cord-023095-4dannjjm 5407 11 use use NN cord-023095-4dannjjm 5407 12 in in IN cord-023095-4dannjjm 5407 13 animals animal NNS cord-023095-4dannjjm 5407 14 due due JJ cord-023095-4dannjjm 5407 15 to to IN cord-023095-4dannjjm 5407 16 its -PRON- PRP$ cord-023095-4dannjjm 5407 17 low low JJ cord-023095-4dannjjm 5407 18 concentration concentration NN cord-023095-4dannjjm 5407 19 and and CC cord-023095-4dannjjm 5407 20 flavoring flavoring NN cord-023095-4dannjjm 5407 21 that that WDT cord-023095-4dannjjm 5407 22 animals animal NNS cord-023095-4dannjjm 5407 23 find find VBP cord-023095-4dannjjm 5407 24 unpalatable unpalatable JJ cord-023095-4dannjjm 5407 25 . . . cord-023095-4dannjjm 5408 1 Because because IN cord-023095-4dannjjm 5408 2 of of IN cord-023095-4dannjjm 5408 3 the the DT cord-023095-4dannjjm 5408 4 known know VBN cord-023095-4dannjjm 5408 5 inherent inherent JJ cord-023095-4dannjjm 5408 6 instability instability NN cord-023095-4dannjjm 5408 7 of of IN cord-023095-4dannjjm 5408 8 doxycline doxycline NN cord-023095-4dannjjm 5408 9 in in IN cord-023095-4dannjjm 5408 10 aqueous aqueous JJ cord-023095-4dannjjm 5408 11 vehicles vehicle NNS cord-023095-4dannjjm 5408 12 under under IN cord-023095-4dannjjm 5408 13 storage storage NN cord-023095-4dannjjm 5408 14 , , , cord-023095-4dannjjm 5408 15 this this DT cord-023095-4dannjjm 5408 16 study study NN cord-023095-4dannjjm 5408 17 was be VBD cord-023095-4dannjjm 5408 18 conducted conduct VBN cord-023095-4dannjjm 5408 19 to to TO cord-023095-4dannjjm 5408 20 determine determine VB cord-023095-4dannjjm 5408 21 the the DT cord-023095-4dannjjm 5408 22 potency potency NN cord-023095-4dannjjm 5408 23 of of IN cord-023095-4dannjjm 5408 24 two two CD cord-023095-4dannjjm 5408 25 formulations formulation NNS cord-023095-4dannjjm 5408 26 stored store VBN cord-023095-4dannjjm 5408 27 in in IN cord-023095-4dannjjm 5408 28 dark dark JJ cord-023095-4dannjjm 5408 29 and and CC cord-023095-4dannjjm 5408 30 light light JJ cord-023095-4dannjjm 5408 31 conditions condition NNS cord-023095-4dannjjm 5408 32 . . . cord-023095-4dannjjm 5409 1 A a DT cord-023095-4dannjjm 5409 2 high high JJ cord-023095-4dannjjm 5409 3 pressure pressure NN cord-023095-4dannjjm 5409 4 liquid liquid NN cord-023095-4dannjjm 5409 5 chromatography chromatography NN cord-023095-4dannjjm 5409 6 ( ( -LRB- cord-023095-4dannjjm 5409 7 HPLC HPLC NNP cord-023095-4dannjjm 5409 8 ) ) -RRB- cord-023095-4dannjjm 5409 9 assay assay NN cord-023095-4dannjjm 5409 10 with with IN cord-023095-4dannjjm 5409 11 UV uv NN cord-023095-4dannjjm 5409 12 absorption absorption NN cord-023095-4dannjjm 5409 13 at at IN cord-023095-4dannjjm 5409 14 350 350 CD cord-023095-4dannjjm 5409 15 nm nm NN cord-023095-4dannjjm 5409 16 was be VBD cord-023095-4dannjjm 5409 17 developed develop VBN cord-023095-4dannjjm 5409 18 for for IN cord-023095-4dannjjm 5409 19 analyzing analyze VBG cord-023095-4dannjjm 5409 20 doxycycline doxycycline NN cord-023095-4dannjjm 5409 21 in in IN cord-023095-4dannjjm 5409 22 formulations formulation NNS cord-023095-4dannjjm 5409 23 , , , cord-023095-4dannjjm 5409 24 in in IN cord-023095-4dannjjm 5409 25 comparison comparison NN cord-023095-4dannjjm 5409 26 to to IN cord-023095-4dannjjm 5409 27 a a DT cord-023095-4dannjjm 5409 28 reference reference NN cord-023095-4dannjjm 5409 29 standard standard NN cord-023095-4dannjjm 5409 30 from from IN cord-023095-4dannjjm 5409 31 the the DT cord-023095-4dannjjm 5409 32 United United NNP cord-023095-4dannjjm 5409 33 States States NNP cord-023095-4dannjjm 5409 34 Pharmacopeia Pharmacopeia NNP cord-023095-4dannjjm 5409 35 ( ( -LRB- cord-023095-4dannjjm 5409 36 USP USP NNP cord-023095-4dannjjm 5409 37 ) ) -RRB- cord-023095-4dannjjm 5409 38 . . . cord-023095-4dannjjm 5410 1 Doxycycline Doxycycline NNP cord-023095-4dannjjm 5410 2 hyclate hyclate NNP cord-023095-4dannjjm 5411 1 100 100 CD cord-023095-4dannjjm 5411 2 mg mg NN cord-023095-4dannjjm 5411 3 tablets tablet NNS cord-023095-4dannjjm 5411 4 were be VBD cord-023095-4dannjjm 5411 5 first first RB cord-023095-4dannjjm 5411 6 tested test VBN cord-023095-4dannjjm 5411 7 for for IN cord-023095-4dannjjm 5411 8 potency potency NN cord-023095-4dannjjm 5411 9 . . . cord-023095-4dannjjm 5412 1 The the DT cord-023095-4dannjjm 5412 2 tablets tablet NNS cord-023095-4dannjjm 5412 3 were be VBD cord-023095-4dannjjm 5412 4 then then RB cord-023095-4dannjjm 5412 5 crushed crush VBN cord-023095-4dannjjm 5412 6 and and CC cord-023095-4dannjjm 5412 7 mixed mix VBN cord-023095-4dannjjm 5412 8 with with IN cord-023095-4dannjjm 5412 9 a a DT cord-023095-4dannjjm 5412 10 pharmaceutical pharmaceutical JJ cord-023095-4dannjjm 5412 11 vehicle vehicle NN cord-023095-4dannjjm 5412 12 to to TO cord-023095-4dannjjm 5412 13 make make VB cord-023095-4dannjjm 5412 14 two two CD cord-023095-4dannjjm 5412 15 concentrations concentration NNS cord-023095-4dannjjm 5412 16 : : : cord-023095-4dannjjm 5412 17 33.3 33.3 CD cord-023095-4dannjjm 5412 18 mg mg NNP cord-023095-4dannjjm 5412 19 / / SYM cord-023095-4dannjjm 5412 20 mL mL NNP cord-023095-4dannjjm 5412 21 and and CC cord-023095-4dannjjm 5412 22 166.7 166.7 CD cord-023095-4dannjjm 5412 23 mg/ mg/ NN cord-023095-4dannjjm 5413 1 mL. mL. NNP cord-023095-4dannjjm 5414 1 The the DT cord-023095-4dannjjm 5414 2 vehicle vehicle NN cord-023095-4dannjjm 5414 3 used use VBN cord-023095-4dannjjm 5414 4 was be VBD cord-023095-4dannjjm 5414 5 a a DT cord-023095-4dannjjm 5414 6 50:50 50:50 CD cord-023095-4dannjjm 5414 7 mixture mixture NN cord-023095-4dannjjm 5414 8 of of IN cord-023095-4dannjjm 5414 9 a a DT cord-023095-4dannjjm 5414 10 Vehicle vehicle NN cord-023095-4dannjjm 5414 11 for for IN cord-023095-4dannjjm 5414 12 Oral Oral NNP cord-023095-4dannjjm 5414 13 Solution Solution NNP cord-023095-4dannjjm 5415 1 ( ( -LRB- cord-023095-4dannjjm 5415 2 Ora Ora NNP cord-023095-4dannjjm 5415 3 - - HYPH cord-023095-4dannjjm 5415 4 Sweet Sweet NNP cord-023095-4dannjjm 5415 5 , , , cord-023095-4dannjjm 5415 6 USP USP NNP cord-023095-4dannjjm 5415 7 - - HYPH cord-023095-4dannjjm 5415 8 NF NF NNP cord-023095-4dannjjm 5415 9 ) ) -RRB- cord-023095-4dannjjm 5415 10 and and CC cord-023095-4dannjjm 5415 11 Vehicle Vehicle NNP cord-023095-4dannjjm 5415 12 for for IN cord-023095-4dannjjm 5415 13 Oral Oral NNP cord-023095-4dannjjm 5415 14 Suspension suspension NN cord-023095-4dannjjm 5416 1 ( ( -LRB- cord-023095-4dannjjm 5416 2 Ora Ora NNP cord-023095-4dannjjm 5416 3 - - HYPH cord-023095-4dannjjm 5416 4 Plus Plus NNP cord-023095-4dannjjm 5416 5 , , , cord-023095-4dannjjm 5416 6 USP USP NNP cord-023095-4dannjjm 5416 7 - - HYPH cord-023095-4dannjjm 5416 8 NF NF NNP cord-023095-4dannjjm 5416 9 ) ) -RRB- cord-023095-4dannjjm 5416 10 . . . cord-023095-4dannjjm 5417 1 The the DT cord-023095-4dannjjm 5417 2 suspensions suspension NNS cord-023095-4dannjjm 5417 3 were be VBD cord-023095-4dannjjm 5417 4 prepared prepare VBN cord-023095-4dannjjm 5417 5 in in IN cord-023095-4dannjjm 5417 6 replicates replicate NNS cord-023095-4dannjjm 5417 7 of of IN cord-023095-4dannjjm 5417 8 3 3 CD cord-023095-4dannjjm 5417 9 . . . cord-023095-4dannjjm 5418 1 Each each DT cord-023095-4dannjjm 5418 2 replicate replicate NN cord-023095-4dannjjm 5418 3 was be VBD cord-023095-4dannjjm 5418 4 divided divide VBN cord-023095-4dannjjm 5418 5 , , , cord-023095-4dannjjm 5418 6 with with IN cord-023095-4dannjjm 5418 7 one one CD cord-023095-4dannjjm 5418 8 aliquot aliquot NN cord-023095-4dannjjm 5418 9 stored store VBN cord-023095-4dannjjm 5418 10 at at IN cord-023095-4dannjjm 5418 11 room room NN cord-023095-4dannjjm 5418 12 temperature temperature NN cord-023095-4dannjjm 5418 13 in in IN cord-023095-4dannjjm 5418 14 lighted light VBN cord-023095-4dannjjm 5418 15 conditions condition NNS cord-023095-4dannjjm 5418 16 , , , cord-023095-4dannjjm 5418 17 and and CC cord-023095-4dannjjm 5418 18 the the DT cord-023095-4dannjjm 5418 19 other other JJ cord-023095-4dannjjm 5418 20 aliquot aliquot NN cord-023095-4dannjjm 5418 21 stored store VBN cord-023095-4dannjjm 5418 22 at at IN cord-023095-4dannjjm 5418 23 room room NN cord-023095-4dannjjm 5418 24 temperature temperature NN cord-023095-4dannjjm 5418 25 in in IN cord-023095-4dannjjm 5418 26 the the DT cord-023095-4dannjjm 5418 27 dark dark NN cord-023095-4dannjjm 5418 28 . . . cord-023095-4dannjjm 5419 1 Doxycycline Doxycycline NNP cord-023095-4dannjjm 5419 2 was be VBD cord-023095-4dannjjm 5419 3 extracted extract VBN cord-023095-4dannjjm 5419 4 from from IN cord-023095-4dannjjm 5419 5 the the DT cord-023095-4dannjjm 5419 6 formulations formulation NNS cord-023095-4dannjjm 5419 7 and and CC cord-023095-4dannjjm 5419 8 measured measure VBN cord-023095-4dannjjm 5419 9 by by IN cord-023095-4dannjjm 5419 10 HPLC HPLC NNP cord-023095-4dannjjm 5419 11 at at IN cord-023095-4dannjjm 5419 12 Day day NN cord-023095-4dannjjm 5419 13 0 0 CD cord-023095-4dannjjm 5419 14 , , , cord-023095-4dannjjm 5419 15 1 1 CD cord-023095-4dannjjm 5419 16 , , , cord-023095-4dannjjm 5419 17 4 4 CD cord-023095-4dannjjm 5419 18 , , , cord-023095-4dannjjm 5419 19 7 7 CD cord-023095-4dannjjm 5419 20 , , , cord-023095-4dannjjm 5419 21 14 14 CD cord-023095-4dannjjm 5419 22 , , , cord-023095-4dannjjm 5419 23 21 21 CD cord-023095-4dannjjm 5419 24 , , , cord-023095-4dannjjm 5419 25 and and CC cord-023095-4dannjjm 5419 26 28 28 CD cord-023095-4dannjjm 5419 27 . . . cord-023095-4dannjjm 5420 1 Each each DT cord-023095-4dannjjm 5420 2 replicate replicate NN cord-023095-4dannjjm 5420 3 was be VBD cord-023095-4dannjjm 5420 4 tested test VBN cord-023095-4dannjjm 5420 5 and and CC cord-023095-4dannjjm 5420 6 the the DT cord-023095-4dannjjm 5420 7 potency potency NN cord-023095-4dannjjm 5420 8 reported report VBN cord-023095-4dannjjm 5420 9 as as IN cord-023095-4dannjjm 5420 10 the the DT cord-023095-4dannjjm 5420 11 percent percent NN cord-023095-4dannjjm 5420 12 doxycycline doxycycline NN cord-023095-4dannjjm 5420 13 relative relative JJ cord-023095-4dannjjm 5420 14 to to IN cord-023095-4dannjjm 5420 15 the the DT cord-023095-4dannjjm 5420 16 USP USP NNP cord-023095-4dannjjm 5420 17 reference reference NN cord-023095-4dannjjm 5420 18 standard standard NN cord-023095-4dannjjm 5420 19 . . . cord-023095-4dannjjm 5421 1 On on IN cord-023095-4dannjjm 5421 2 Day day NN cord-023095-4dannjjm 5421 3 0 0 CD cord-023095-4dannjjm 5421 4 , , , cord-023095-4dannjjm 5421 5 1 1 CD cord-023095-4dannjjm 5421 6 , , , cord-023095-4dannjjm 5421 7 4 4 CD cord-023095-4dannjjm 5421 8 , , , cord-023095-4dannjjm 5421 9 and and CC cord-023095-4dannjjm 5421 10 7 7 CD cord-023095-4dannjjm 5421 11 , , , cord-023095-4dannjjm 5421 12 the the DT cord-023095-4dannjjm 5421 13 potency potency NN cord-023095-4dannjjm 5421 14 of of IN cord-023095-4dannjjm 5421 15 each each DT cord-023095-4dannjjm 5421 16 formulation formulation NN cord-023095-4dannjjm 5421 17 was be VBD cord-023095-4dannjjm 5421 18 within within IN cord-023095-4dannjjm 5421 19 90 90 CD cord-023095-4dannjjm 5421 20 - - SYM cord-023095-4dannjjm 5421 21 110 110 CD cord-023095-4dannjjm 5421 22 % % NN cord-023095-4dannjjm 5421 23 of of IN cord-023095-4dannjjm 5421 24 the the DT cord-023095-4dannjjm 5421 25 reference reference NN cord-023095-4dannjjm 5421 26 standard standard NN cord-023095-4dannjjm 5421 27 ( ( -LRB- cord-023095-4dannjjm 5421 28 range range VB cord-023095-4dannjjm 5421 29 93.4 93.4 CD cord-023095-4dannjjm 5421 30 - - SYM cord-023095-4dannjjm 5421 31 109 109 CD cord-023095-4dannjjm 5421 32 % % NN cord-023095-4dannjjm 5421 33 ) ) -RRB- cord-023095-4dannjjm 5421 34 . . . cord-023095-4dannjjm 5422 1 This this DT cord-023095-4dannjjm 5422 2 value value NN cord-023095-4dannjjm 5422 3 is be VBZ cord-023095-4dannjjm 5422 4 within within IN cord-023095-4dannjjm 5422 5 the the DT cord-023095-4dannjjm 5422 6 accepted accept VBN cord-023095-4dannjjm 5422 7 range range NN cord-023095-4dannjjm 5422 8 cited cite VBN cord-023095-4dannjjm 5422 9 in in IN cord-023095-4dannjjm 5422 10 USP USP NNP cord-023095-4dannjjm 5422 11 o o NNP cord-023095-4dannjjm 5422 12 795 795 CD cord-023095-4dannjjm 5422 13 4 4 CD cord-023095-4dannjjm 5422 14 on on IN cord-023095-4dannjjm 5422 15 Pharmaceutical Pharmaceutical NNP cord-023095-4dannjjm 5422 16 Compounding Compounding NNP cord-023095-4dannjjm 5422 17 - - HYPH cord-023095-4dannjjm 5422 18 Non Non NNP cord-023095-4dannjjm 5422 19 - - JJ cord-023095-4dannjjm 5422 20 Sterile sterile JJ cord-023095-4dannjjm 5422 21 Preparations preparation NNS cord-023095-4dannjjm 5422 22 . . . cord-023095-4dannjjm 5423 1 However however RB cord-023095-4dannjjm 5423 2 , , , cord-023095-4dannjjm 5423 3 starting start VBG cord-023095-4dannjjm 5423 4 at at IN cord-023095-4dannjjm 5423 5 Day day NN cord-023095-4dannjjm 5423 6 14 14 CD cord-023095-4dannjjm 5423 7 , , , cord-023095-4dannjjm 5423 8 the the DT cord-023095-4dannjjm 5423 9 potency potency NN cord-023095-4dannjjm 5423 10 declined decline VBD cord-023095-4dannjjm 5423 11 dramatically dramatically RB cord-023095-4dannjjm 5423 12 and and CC cord-023095-4dannjjm 5423 13 remained remain VBD cord-023095-4dannjjm 5423 14 low low JJ cord-023095-4dannjjm 5423 15 for for IN cord-023095-4dannjjm 5423 16 the the DT cord-023095-4dannjjm 5423 17 tests test NNS cord-023095-4dannjjm 5423 18 performed perform VBN cord-023095-4dannjjm 5423 19 on on IN cord-023095-4dannjjm 5423 20 Day Day NNP cord-023095-4dannjjm 5423 21 21 21 CD cord-023095-4dannjjm 5423 22 and and CC cord-023095-4dannjjm 5423 23 28 28 CD cord-023095-4dannjjm 5423 24 . . . cord-023095-4dannjjm 5424 1 The the DT cord-023095-4dannjjm 5424 2 potency potency NN cord-023095-4dannjjm 5424 3 on on IN cord-023095-4dannjjm 5424 4 Day Day NNP cord-023095-4dannjjm 5424 5 14 14 CD cord-023095-4dannjjm 5424 6 , , , cord-023095-4dannjjm 5424 7 21 21 CD cord-023095-4dannjjm 5424 8 , , , cord-023095-4dannjjm 5424 9 and and CC cord-023095-4dannjjm 5424 10 28 28 CD cord-023095-4dannjjm 5424 11 was be VBD cord-023095-4dannjjm 5424 12 below below IN cord-023095-4dannjjm 5424 13 20 20 CD cord-023095-4dannjjm 5424 14 % % NN cord-023095-4dannjjm 5424 15 of of IN cord-023095-4dannjjm 5424 16 the the DT cord-023095-4dannjjm 5424 17 reference reference NN cord-023095-4dannjjm 5424 18 standard standard NN cord-023095-4dannjjm 5424 19 ( ( -LRB- cord-023095-4dannjjm 5424 20 range range NNP cord-023095-4dannjjm 5424 21 14 14 CD cord-023095-4dannjjm 5424 22 - - SYM cord-023095-4dannjjm 5424 23 18 18 CD cord-023095-4dannjjm 5424 24 % % NN cord-023095-4dannjjm 5424 25 ) ) -RRB- cord-023095-4dannjjm 5424 26 . . . cord-023095-4dannjjm 5425 1 There there EX cord-023095-4dannjjm 5425 2 was be VBD cord-023095-4dannjjm 5425 3 also also RB cord-023095-4dannjjm 5425 4 a a DT cord-023095-4dannjjm 5425 5 noticeable noticeable JJ cord-023095-4dannjjm 5425 6 change change NN cord-023095-4dannjjm 5425 7 in in IN cord-023095-4dannjjm 5425 8 the the DT cord-023095-4dannjjm 5425 9 quality quality NN cord-023095-4dannjjm 5425 10 of of IN cord-023095-4dannjjm 5425 11 the the DT cord-023095-4dannjjm 5425 12 formulation formulation NN cord-023095-4dannjjm 5425 13 starting start VBG cord-023095-4dannjjm 5425 14 on on IN cord-023095-4dannjjm 5425 15 Day Day NNP cord-023095-4dannjjm 5425 16 14 14 CD cord-023095-4dannjjm 5425 17 , , , cord-023095-4dannjjm 5425 18 and and CC cord-023095-4dannjjm 5425 19 a a DT cord-023095-4dannjjm 5425 20 change change NN cord-023095-4dannjjm 5425 21 in in IN cord-023095-4dannjjm 5425 22 the the DT cord-023095-4dannjjm 5425 23 color color NN cord-023095-4dannjjm 5425 24 of of IN cord-023095-4dannjjm 5425 25 the the DT cord-023095-4dannjjm 5425 26 formulation formulation NN cord-023095-4dannjjm 5425 27 to to IN cord-023095-4dannjjm 5425 28 a a DT cord-023095-4dannjjm 5425 29 dark dark JJ cord-023095-4dannjjm 5425 30 brown brown NN cord-023095-4dannjjm 5425 31 . . . cord-023095-4dannjjm 5426 1 These these DT cord-023095-4dannjjm 5426 2 results result NNS cord-023095-4dannjjm 5426 3 indicate indicate VBP cord-023095-4dannjjm 5426 4 that that IN cord-023095-4dannjjm 5426 5 when when WRB cord-023095-4dannjjm 5426 6 doxycycline doxycycline NNP cord-023095-4dannjjm 5426 7 hyclate hyclate NNP cord-023095-4dannjjm 5426 8 tablets tablet NNS cord-023095-4dannjjm 5426 9 are be VBP cord-023095-4dannjjm 5426 10 compounded compound VBN cord-023095-4dannjjm 5426 11 as as IN cord-023095-4dannjjm 5426 12 a a DT cord-023095-4dannjjm 5426 13 suspension suspension NN cord-023095-4dannjjm 5426 14 in in IN cord-023095-4dannjjm 5426 15 an an DT cord-023095-4dannjjm 5426 16 aqueous aqueous JJ cord-023095-4dannjjm 5426 17 vehicle vehicle NN cord-023095-4dannjjm 5426 18 as as IN cord-023095-4dannjjm 5426 19 described describe VBN cord-023095-4dannjjm 5426 20 in in IN cord-023095-4dannjjm 5426 21 this this DT cord-023095-4dannjjm 5426 22 study study NN cord-023095-4dannjjm 5426 23 , , , cord-023095-4dannjjm 5426 24 at at IN cord-023095-4dannjjm 5426 25 33.3 33.3 CD cord-023095-4dannjjm 5426 26 and and CC cord-023095-4dannjjm 5426 27 166.7 166.7 CD cord-023095-4dannjjm 5426 28 mg mg NNP cord-023095-4dannjjm 5426 29 / / SYM cord-023095-4dannjjm 5426 30 mL ml NN cord-023095-4dannjjm 5426 31 under under IN cord-023095-4dannjjm 5426 32 the the DT cord-023095-4dannjjm 5426 33 storage storage NN cord-023095-4dannjjm 5426 34 conditions condition NNS cord-023095-4dannjjm 5426 35 used use VBN cord-023095-4dannjjm 5426 36 in in IN cord-023095-4dannjjm 5426 37 this this DT cord-023095-4dannjjm 5426 38 study study NN cord-023095-4dannjjm 5426 39 , , , cord-023095-4dannjjm 5426 40 potency potency NN cord-023095-4dannjjm 5426 41 of of IN cord-023095-4dannjjm 5426 42 the the DT cord-023095-4dannjjm 5426 43 formulation formulation NN cord-023095-4dannjjm 5426 44 can can MD cord-023095-4dannjjm 5426 45 not not RB cord-023095-4dannjjm 5426 46 be be VB cord-023095-4dannjjm 5426 47 assured assure VBN cord-023095-4dannjjm 5426 48 beyond beyond IN cord-023095-4dannjjm 5426 49 7 7 CD cord-023095-4dannjjm 5426 50 days day NNS cord-023095-4dannjjm 5426 51 . . . cord-023095-4dannjjm 5427 1 We -PRON- PRP cord-023095-4dannjjm 5427 2 recommend recommend VBP cord-023095-4dannjjm 5427 3 a a DT cord-023095-4dannjjm 5427 4 beyond beyond IN cord-023095-4dannjjm 5427 5 - - HYPH cord-023095-4dannjjm 5427 6 use use NN cord-023095-4dannjjm 5427 7 - - HYPH cord-023095-4dannjjm 5427 8 day day NN cord-023095-4dannjjm 5427 9 ( ( -LRB- cord-023095-4dannjjm 5427 10 BUD BUD NNP cord-023095-4dannjjm 5427 11 ) ) -RRB- cord-023095-4dannjjm 5427 12 of of IN cord-023095-4dannjjm 5427 13 7 7 CD cord-023095-4dannjjm 5427 14 days day NNS cord-023095-4dannjjm 5427 15 for for IN cord-023095-4dannjjm 5427 16 formulations formulation NNS cord-023095-4dannjjm 5427 17 prepared prepare VBN cord-023095-4dannjjm 5427 18 and and CC cord-023095-4dannjjm 5427 19 stored store VBN cord-023095-4dannjjm 5427 20 at at IN cord-023095-4dannjjm 5427 21 room room NN cord-023095-4dannjjm 5427 22 temperature temperature NN cord-023095-4dannjjm 5427 23 in in IN cord-023095-4dannjjm 5427 24 light light JJ cord-023095-4dannjjm 5427 25 or or CC cord-023095-4dannjjm 5427 26 dark dark JJ cord-023095-4dannjjm 5427 27 conditions condition NNS cord-023095-4dannjjm 5427 28 . . . cord-023095-4dannjjm 5428 1 Therapeutic therapeutic JJ cord-023095-4dannjjm 5428 2 options option NNS cord-023095-4dannjjm 5428 3 for for IN cord-023095-4dannjjm 5428 4 multidrug multidrug NN cord-023095-4dannjjm 5428 5 resistance resistance NN cord-023095-4dannjjm 5428 6 ( ( -LRB- cord-023095-4dannjjm 5428 7 MDR MDR NNP cord-023095-4dannjjm 5428 8 ) ) -RRB- cord-023095-4dannjjm 5428 9 Escherichia Escherichia NNP cord-023095-4dannjjm 5428 10 coli coli VBZ cord-023095-4dannjjm 5428 11 urinary urinary JJ cord-023095-4dannjjm 5428 12 tract tract JJ cord-023095-4dannjjm 5428 13 infections infection NNS cord-023095-4dannjjm 5428 14 ( ( -LRB- cord-023095-4dannjjm 5428 15 UTI UTI NNP cord-023095-4dannjjm 5428 16 ) ) -RRB- cord-023095-4dannjjm 5428 17 are be VBP cord-023095-4dannjjm 5428 18 limited limit VBN cord-023095-4dannjjm 5428 19 . . . cord-023095-4dannjjm 5429 1 Fosfomycin Fosfomycin NNP cord-023095-4dannjjm 5429 2 ( ( -LRB- cord-023095-4dannjjm 5429 3 FOS FOS NNP cord-023095-4dannjjm 5429 4 ) ) -RRB- cord-023095-4dannjjm 5429 5 tromethamine tromethamine NNP cord-023095-4dannjjm 5429 6 is be VBZ cord-023095-4dannjjm 5429 7 an an DT cord-023095-4dannjjm 5429 8 oral oral JJ cord-023095-4dannjjm 5429 9 , , , cord-023095-4dannjjm 5429 10 broad broad JJ cord-023095-4dannjjm 5429 11 - - HYPH cord-023095-4dannjjm 5429 12 spectrum spectrum NN cord-023095-4dannjjm 5429 13 , , , cord-023095-4dannjjm 5429 14 cell cell NN cord-023095-4dannjjm 5429 15 - - HYPH cord-023095-4dannjjm 5429 16 wall wall NN cord-023095-4dannjjm 5429 17 active active JJ cord-023095-4dannjjm 5429 18 , , , cord-023095-4dannjjm 5429 19 bactericidal bactericidal JJ cord-023095-4dannjjm 5429 20 drug drug NN cord-023095-4dannjjm 5429 21 approved approve VBN cord-023095-4dannjjm 5429 22 for for IN cord-023095-4dannjjm 5429 23 treatment treatment NN cord-023095-4dannjjm 5429 24 of of IN cord-023095-4dannjjm 5429 25 uncomplicated uncomplicated JJ cord-023095-4dannjjm 5429 26 UTI UTI NNP cord-023095-4dannjjm 5429 27 in in IN cord-023095-4dannjjm 5429 28 humans human NNS cord-023095-4dannjjm 5429 29 . . . cord-023095-4dannjjm 5430 1 The the DT cord-023095-4dannjjm 5430 2 purpose purpose NN cord-023095-4dannjjm 5430 3 of of IN cord-023095-4dannjjm 5430 4 this this DT cord-023095-4dannjjm 5430 5 study study NN cord-023095-4dannjjm 5430 6 was be VBD cord-023095-4dannjjm 5430 7 to to TO cord-023095-4dannjjm 5430 8 determine determine VB cord-023095-4dannjjm 5430 9 time time NN cord-023095-4dannjjm 5430 10 dependency dependency NN cord-023095-4dannjjm 5430 11 of of IN cord-023095-4dannjjm 5430 12 FOS FOS NNP cord-023095-4dannjjm 5430 13 and and CC cord-023095-4dannjjm 5430 14 the the DT cord-023095-4dannjjm 5430 15 disposition disposition NN cord-023095-4dannjjm 5430 16 of of IN cord-023095-4dannjjm 5430 17 FOS FOS NNP cord-023095-4dannjjm 5430 18 tromethamine tromethamine NN cord-023095-4dannjjm 5430 19 in in IN cord-023095-4dannjjm 5430 20 dogs dog NNS cord-023095-4dannjjm 5430 21 . . . cord-023095-4dannjjm 5431 1 Using use VBG cord-023095-4dannjjm 5431 2 a a DT cord-023095-4dannjjm 5431 3 randomized randomized JJ cord-023095-4dannjjm 5431 4 , , , cord-023095-4dannjjm 5431 5 double double JJ cord-023095-4dannjjm 5431 6 crossover crossover NN cord-023095-4dannjjm 5431 7 design design NN cord-023095-4dannjjm 5431 8 , , , cord-023095-4dannjjm 5431 9 12 12 CD cord-023095-4dannjjm 5431 10 client client NN cord-023095-4dannjjm 5431 11 - - HYPH cord-023095-4dannjjm 5431 12 owned own VBN cord-023095-4dannjjm 5431 13 dogs dog NNS cord-023095-4dannjjm 5431 14 received receive VBD cord-023095-4dannjjm 5431 15 FOS FOS NNP cord-023095-4dannjjm 5431 16 sodium sodium NN cord-023095-4dannjjm 5431 17 IV IV NNP cord-023095-4dannjjm 5431 18 ( ( -LRB- cord-023095-4dannjjm 5431 19 40 40 CD cord-023095-4dannjjm 5431 20 mg mg NNP cord-023095-4dannjjm 5431 21 / / SYM cord-023095-4dannjjm 5431 22 kg kg NNP cord-023095-4dannjjm 5431 23 ) ) -RRB- cord-023095-4dannjjm 5431 24 and and CC cord-023095-4dannjjm 5431 25 FOS FOS NNP cord-023095-4dannjjm 5431 26 tromethamine tromethamine NNP cord-023095-4dannjjm 5431 27 ( ( -LRB- cord-023095-4dannjjm 5431 28 PO PO NNP cord-023095-4dannjjm 5431 29 , , , cord-023095-4dannjjm 5431 30 80 80 CD cord-023095-4dannjjm 5431 31 mg mg NNP cord-023095-4dannjjm 5431 32 / / SYM cord-023095-4dannjjm 5431 33 kg kg NN cord-023095-4dannjjm 5431 34 ) ) -RRB- cord-023095-4dannjjm 5432 1 either either CC cord-023095-4dannjjm 5432 2 with with IN cord-023095-4dannjjm 5432 3 ( ( -LRB- cord-023095-4dannjjm 5432 4 n n NN cord-023095-4dannjjm 5432 5 5 5 CD cord-023095-4dannjjm 5432 6 6 6 CD cord-023095-4dannjjm 5432 7 ) ) -RRB- cord-023095-4dannjjm 5432 8 or or CC cord-023095-4dannjjm 5432 9 without without IN cord-023095-4dannjjm 5432 10 food food NN cord-023095-4dannjjm 5432 11 ( ( -LRB- cord-023095-4dannjjm 5432 12 n n NN cord-023095-4dannjjm 5432 13 5 5 CD cord-023095-4dannjjm 5432 14 6 6 CD cord-023095-4dannjjm 5432 15 ) ) -RRB- cord-023095-4dannjjm 5432 16 . . . cord-023095-4dannjjm 5433 1 Serum serum NN cord-023095-4dannjjm 5433 2 and and CC cord-023095-4dannjjm 5433 3 urine urine NN cord-023095-4dannjjm 5433 4 were be VBD cord-023095-4dannjjm 5433 5 collected collect VBN cord-023095-4dannjjm 5433 6 for for IN cord-023095-4dannjjm 5433 7 24 24 CD cord-023095-4dannjjm 5433 8 hr hr NN cord-023095-4dannjjm 5433 9 ; ; : cord-023095-4dannjjm 5433 10 FOS FOS NNP cord-023095-4dannjjm 5433 11 was be VBD cord-023095-4dannjjm 5433 12 quantitated quantitate VBN cord-023095-4dannjjm 5433 13 with with IN cord-023095-4dannjjm 5433 14 a a DT cord-023095-4dannjjm 5433 15 bioassay bioassay NN cord-023095-4dannjjm 5433 16 ( ( -LRB- cord-023095-4dannjjm 5433 17 ATCC ATCC NNP cord-023095-4dannjjm 5433 18 E. E. NNP cord-023095-4dannjjm 5433 19 coli coli VBZ cord-023095-4dannjjm 5433 20 25922 25922 CD cord-023095-4dannjjm 5433 21 , , , cord-023095-4dannjjm 5433 22 serum serum NN cord-023095-4dannjjm 5433 23 or or CC cord-023095-4dannjjm 5433 24 ATCC atcc JJ cord-023095-4dannjjm 5433 25 Proteus Proteus NNP cord-023095-4dannjjm 5433 26 vulgaris vulgaris NN cord-023095-4dannjjm 5433 27 13315 13315 CD cord-023095-4dannjjm 5433 28 , , , cord-023095-4dannjjm 5433 29 urine urine NN cord-023095-4dannjjm 5433 30 ) ) -RRB- cord-023095-4dannjjm 5433 31 . . . cord-023095-4dannjjm 5434 1 In in IN cord-023095-4dannjjm 5434 2 - - HYPH cord-023095-4dannjjm 5434 3 vitro vitro FW cord-023095-4dannjjm 5434 4 killing killing NN cord-023095-4dannjjm 5434 5 curves curve NNS cord-023095-4dannjjm 5434 6 ( ( -LRB- cord-023095-4dannjjm 5434 7 cell cell NN cord-023095-4dannjjm 5434 8 counts count VBZ cord-023095-4dannjjm 5434 9 through through IN cord-023095-4dannjjm 5434 10 24 24 CD cord-023095-4dannjjm 5434 11 hours hour NNS cord-023095-4dannjjm 5434 12 ) ) -RRB- cord-023095-4dannjjm 5434 13 were be VBD cord-023095-4dannjjm 5434 14 performed perform VBN cord-023095-4dannjjm 5434 15 at at IN cord-023095-4dannjjm 5434 16 0 0 CD cord-023095-4dannjjm 5434 17 ( ( -LRB- cord-023095-4dannjjm 5434 18 control),0.5,1,2,8,16 control),0.5,1,2,8,16 NNS cord-023095-4dannjjm 5434 19 and and CC cord-023095-4dannjjm 5434 20 32 32 CD cord-023095-4dannjjm 5434 21 x x SYM cord-023095-4dannjjm 5434 22 MIC MIC NNP cord-023095-4dannjjm 5434 23 for for IN cord-023095-4dannjjm 5434 24 MDR MDR NNP cord-023095-4dannjjm 5434 25 E. E. NNP cord-023095-4dannjjm 5434 26 coli coli VBZ cord-023095-4dannjjm 5434 27 canine canine JJ cord-023095-4dannjjm 5434 28 FOS FOS NNP cord-023095-4dannjjm 5434 29 susceptible susceptible JJ cord-023095-4dannjjm 5434 30 ( ( -LRB- cord-023095-4dannjjm 5434 31 E e NN cord-023095-4dannjjm 5434 32 - - NN cord-023095-4dannjjm 5434 33 test test NN cord-023095-4dannjjm 5434 34 s s NNS cord-023095-4dannjjm 5434 35 ) ) -RRB- cord-023095-4dannjjm 5434 36 uropathogens uropathogen NNS cord-023095-4dannjjm 5434 37 . . . cord-023095-4dannjjm 5435 1 Killing kill VBG cord-023095-4dannjjm 5435 2 curves curve NNS cord-023095-4dannjjm 5435 3 indicated indicate VBD cord-023095-4dannjjm 5435 4 FOS FOS NNP cord-023095-4dannjjm 5435 5 to to TO cord-023095-4dannjjm 5435 6 be be VB cord-023095-4dannjjm 5435 7 time time NN cord-023095-4dannjjm 5435 8 dependent dependent JJ cord-023095-4dannjjm 5435 9 . . . cord-023095-4dannjjm 5436 1 After after IN cord-023095-4dannjjm 5436 2 IV IV NNP cord-023095-4dannjjm 5436 3 administration administration NN cord-023095-4dannjjm 5436 4 , , , cord-023095-4dannjjm 5436 5 clearance clearance NN cord-023095-4dannjjm 5436 6 ( ( -LRB- cord-023095-4dannjjm 5436 7 mlÃkg mlÃkg NNP cord-023095-4dannjjm 5436 8 / / SYM cord-023095-4dannjjm 5436 9 hr hr NN cord-023095-4dannjjm 5436 10 ) ) -RRB- cord-023095-4dannjjm 5436 11 , , , cord-023095-4dannjjm 5436 12 volume volume NN cord-023095-4dannjjm 5436 13 of of IN cord-023095-4dannjjm 5436 14 distribution distribution NN cord-023095-4dannjjm 5436 15 ( ( -LRB- cord-023095-4dannjjm 5436 16 L l NN cord-023095-4dannjjm 5436 17 / / SYM cord-023095-4dannjjm 5436 18 kg kg NNP cord-023095-4dannjjm 5436 19 ) ) -RRB- cord-023095-4dannjjm 5436 20 , , , cord-023095-4dannjjm 5436 21 elimination elimination NN cord-023095-4dannjjm 5436 22 half half JJ cord-023095-4dannjjm 5436 23 - - HYPH cord-023095-4dannjjm 5436 24 life life NN cord-023095-4dannjjm 5436 25 ( ( -LRB- cord-023095-4dannjjm 5436 26 HL HL NNP cord-023095-4dannjjm 5436 27 ; ; : cord-023095-4dannjjm 5436 28 hr hr NN cord-023095-4dannjjm 5436 29 ) ) -RRB- cord-023095-4dannjjm 5436 30 and and CC cord-023095-4dannjjm 5436 31 mean mean VB cord-023095-4dannjjm 5436 32 residence residence NN cord-023095-4dannjjm 5436 33 time time NN cord-023095-4dannjjm 5436 34 ( ( -LRB- cord-023095-4dannjjm 5436 35 MRT MRT NNP cord-023095-4dannjjm 5436 36 , , , cord-023095-4dannjjm 5436 37 hr hr NNP cord-023095-4dannjjm 5436 38 ) ) -RRB- cord-023095-4dannjjm 5436 39 were be VBD cord-023095-4dannjjm 5436 40 ( ( -LRB- cord-023095-4dannjjm 5436 41 mean mean VB cord-023095-4dannjjm 5436 42 AE AE NNP cord-023095-4dannjjm 5436 43 sd sd NNP cord-023095-4dannjjm 5436 44 ) ) -RRB- cord-023095-4dannjjm 5436 45 : : : cord-023095-4dannjjm 5436 46 210 210 CD cord-023095-4dannjjm 5436 47 AE AE NNP cord-023095-4dannjjm 5436 48 104 104 CD cord-023095-4dannjjm 5436 49 , , , cord-023095-4dannjjm 5436 50 0.23 0.23 CD cord-023095-4dannjjm 5436 51 AE AE NNP cord-023095-4dannjjm 5436 52 0.15 0.15 CD cord-023095-4dannjjm 5436 53 , , , cord-023095-4dannjjm 5436 54 0.36 0.36 CD cord-023095-4dannjjm 5436 55 AE AE NNP cord-023095-4dannjjm 5436 56 0.19 0.19 CD cord-023095-4dannjjm 5436 57 , , , cord-023095-4dannjjm 5436 58 1.14 1.14 CD cord-023095-4dannjjm 5436 59 AE AE NNP cord-023095-4dannjjm 5436 60 0.35 0.35 CD cord-023095-4dannjjm 5436 61 and and CC cord-023095-4dannjjm 5436 62 1.7 1.7 CD cord-023095-4dannjjm 5436 63 AE AE NNP cord-023095-4dannjjm 5436 64 0.4 0.4 CD cord-023095-4dannjjm 5436 65 , , , cord-023095-4dannjjm 5436 66 respectively respectively RB cord-023095-4dannjjm 5436 67 . . . cord-023095-4dannjjm 5437 1 For for IN cord-023095-4dannjjm 5437 2 PO PO NNP cord-023095-4dannjjm 5437 3 , , , cord-023095-4dannjjm 5437 4 C C NNP cord-023095-4dannjjm 5437 5 max max NN cord-023095-4dannjjm 5437 6 , , , cord-023095-4dannjjm 5437 7 HL HL NNP cord-023095-4dannjjm 5437 8 and and CC cord-023095-4dannjjm 5437 9 MRT MRT NNP cord-023095-4dannjjm 5437 10 were be VBD cord-023095-4dannjjm 5437 11 66 66 CD cord-023095-4dannjjm 5437 12 AE AE NNP cord-023095-4dannjjm 5437 13 21 21 CD cord-023095-4dannjjm 5437 14 , , , cord-023095-4dannjjm 5437 15 2.5 2.5 CD cord-023095-4dannjjm 5437 16 AE AE NNP cord-023095-4dannjjm 5437 17 1.09 1.09 CD cord-023095-4dannjjm 5437 18 and and CC cord-023095-4dannjjm 5437 19 5.1 5.1 CD cord-023095-4dannjjm 5437 20 AE AE NNP cord-023095-4dannjjm 5437 21 1.7 1.7 CD cord-023095-4dannjjm 5437 22 , , , cord-023095-4dannjjm 5437 23 respectively respectively RB cord-023095-4dannjjm 5437 24 . . . cord-023095-4dannjjm 5438 1 Serum serum NN cord-023095-4dannjjm 5438 2 FOS FOS NNP cord-023095-4dannjjm 5438 3 exceeded exceed VBD cord-023095-4dannjjm 5438 4 the the DT cord-023095-4dannjjm 5438 5 MIC MIC NNP cord-023095-4dannjjm 5438 6 90 90 CD cord-023095-4dannjjm 5438 7 reported report VBD cord-023095-4dannjjm 5438 8 for for IN cord-023095-4dannjjm 5438 9 multidrug multidrug NN cord-023095-4dannjjm 5438 10 resistant resistant JJ cord-023095-4dannjjm 5438 11 ( ( -LRB- cord-023095-4dannjjm 5438 12 MDR MDR NNP cord-023095-4dannjjm 5438 13 ) ) -RRB- cord-023095-4dannjjm 5438 14 E. E. NNP cord-023095-4dannjjm 5438 15 coli coli NNS cord-023095-4dannjjm 5438 16 ( ( -LRB- cord-023095-4dannjjm 5438 17 1.5 1.5 CD cord-023095-4dannjjm 5438 18 mg mg NNP cord-023095-4dannjjm 5438 19 / / SYM cord-023095-4dannjjm 5438 20 ml ml NNP cord-023095-4dannjjm 5438 21 ) ) -RRB- cord-023095-4dannjjm 5438 22 for for IN cord-023095-4dannjjm 5438 23 7hr 7hr NNP cord-023095-4dannjjm 5438 24 ( ( -LRB- cord-023095-4dannjjm 5438 25 IV IV NNP cord-023095-4dannjjm 5438 26 ; ; : cord-023095-4dannjjm 5438 27 2.5 2.5 CD cord-023095-4dannjjm 5438 28 mg mg NNP cord-023095-4dannjjm 5438 29 / / SYM cord-023095-4dannjjm 5438 30 ml ml NNP cord-023095-4dannjjm 5438 31 ) ) -RRB- cord-023095-4dannjjm 5438 32 and and CC cord-023095-4dannjjm 5438 33 12hr 12hr NNP cord-023095-4dannjjm 5438 34 ( ( -LRB- cord-023095-4dannjjm 5438 35 PO po NN cord-023095-4dannjjm 5438 36 , , , cord-023095-4dannjjm 5439 1 9 9 CD cord-023095-4dannjjm 5439 2 mg mg NNP cord-023095-4dannjjm 5439 3 / / SYM cord-023095-4dannjjm 5439 4 ml ml NNP cord-023095-4dannjjm 5439 5 Diminazene Diminazene NNP cord-023095-4dannjjm 5439 6 is be VBZ cord-023095-4dannjjm 5439 7 an an DT cord-023095-4dannjjm 5439 8 aromatic aromatic JJ cord-023095-4dannjjm 5439 9 diamidine diamidine NN cord-023095-4dannjjm 5439 10 , , , cord-023095-4dannjjm 5439 11 anti anti JJ cord-023095-4dannjjm 5439 12 - - JJ cord-023095-4dannjjm 5439 13 protozoal protozoal JJ cord-023095-4dannjjm 5439 14 drug drug NN cord-023095-4dannjjm 5439 15 that that WDT cord-023095-4dannjjm 5439 16 has have VBZ cord-023095-4dannjjm 5439 17 shown show VBN cord-023095-4dannjjm 5439 18 promise promise NN cord-023095-4dannjjm 5439 19 in in IN cord-023095-4dannjjm 5439 20 a a DT cord-023095-4dannjjm 5439 21 small small JJ cord-023095-4dannjjm 5439 22 number number NN cord-023095-4dannjjm 5439 23 of of IN cord-023095-4dannjjm 5439 24 cases case NNS cord-023095-4dannjjm 5439 25 of of IN cord-023095-4dannjjm 5439 26 cytauxzoonosis cytauxzoonosis NN cord-023095-4dannjjm 5439 27 . . . cord-023095-4dannjjm 5440 1 In in IN cord-023095-4dannjjm 5440 2 a a DT cord-023095-4dannjjm 5440 3 noncontrolled noncontrolled JJ cord-023095-4dannjjm 5440 4 case case NN cord-023095-4dannjjm 5440 5 series series NN cord-023095-4dannjjm 5440 6 , , , cord-023095-4dannjjm 5440 7 5 5 CD cord-023095-4dannjjm 5440 8 of of IN cord-023095-4dannjjm 5440 9 6 6 CD cord-023095-4dannjjm 5440 10 cats cat NNS cord-023095-4dannjjm 5440 11 with with IN cord-023095-4dannjjm 5440 12 clinical clinical JJ cord-023095-4dannjjm 5440 13 cytauxzoonosis cytauxzoonosis NN cord-023095-4dannjjm 5440 14 given give VBN cord-023095-4dannjjm 5440 15 3 3 CD cord-023095-4dannjjm 5440 16 mg/ mg/ NN cord-023095-4dannjjm 5440 17 kg kg NNP cord-023095-4dannjjm 5440 18 of of IN cord-023095-4dannjjm 5440 19 diminazene diminazene NNP cord-023095-4dannjjm 5440 20 aceturate aceturate NNP cord-023095-4dannjjm 5440 21 survived survive VBD cord-023095-4dannjjm 5440 22 infection infection NN cord-023095-4dannjjm 5440 23 . . . cord-023095-4dannjjm 5441 1 Dosage dosage JJ cord-023095-4dannjjm 5441 2 frequency frequency NN cord-023095-4dannjjm 5441 3 was be VBD cord-023095-4dannjjm 5441 4 two two CD cord-023095-4dannjjm 5441 5 intramuscular intramuscular JJ cord-023095-4dannjjm 5441 6 injections injection NNS cord-023095-4dannjjm 5441 7 given give VBN cord-023095-4dannjjm 5441 8 one one CD cord-023095-4dannjjm 5441 9 week week NN cord-023095-4dannjjm 5441 10 apart apart RB cord-023095-4dannjjm 5441 11 . . . cord-023095-4dannjjm 5442 1 Commercial commercial JJ cord-023095-4dannjjm 5442 2 formulations formulation NNS cord-023095-4dannjjm 5442 3 contain contain VBP cord-023095-4dannjjm 5442 4 the the DT cord-023095-4dannjjm 5442 5 diminazene diminazene NNP cord-023095-4dannjjm 5442 6 diaceturate diaceturate NN cord-023095-4dannjjm 5442 7 salt salt NN cord-023095-4dannjjm 5442 8 . . . cord-023095-4dannjjm 5443 1 The the DT cord-023095-4dannjjm 5443 2 active active JJ cord-023095-4dannjjm 5443 3 base base NN cord-023095-4dannjjm 5443 4 is be VBZ cord-023095-4dannjjm 5443 5 diminazene diminazene NN cord-023095-4dannjjm 5443 6 with with IN cord-023095-4dannjjm 5443 7 the the DT cord-023095-4dannjjm 5443 8 salt salt NN cord-023095-4dannjjm 5443 9 consisting consist VBG cord-023095-4dannjjm 5443 10 of of IN cord-023095-4dannjjm 5443 11 two two CD cord-023095-4dannjjm 5443 12 aceturate aceturate NN cord-023095-4dannjjm 5443 13 molecules molecule NNS cord-023095-4dannjjm 5443 14 . . . cord-023095-4dannjjm 5444 1 Currently currently RB cord-023095-4dannjjm 5444 2 there there EX cord-023095-4dannjjm 5444 3 is be VBZ cord-023095-4dannjjm 5444 4 no no DT cord-023095-4dannjjm 5444 5 data datum NNS cord-023095-4dannjjm 5444 6 available available JJ cord-023095-4dannjjm 5444 7 on on IN cord-023095-4dannjjm 5444 8 the the DT cord-023095-4dannjjm 5444 9 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 5444 10 of of IN cord-023095-4dannjjm 5444 11 either either DT cord-023095-4dannjjm 5444 12 diminazene diminazene NNP cord-023095-4dannjjm 5444 13 compound compound NN cord-023095-4dannjjm 5444 14 in in IN cord-023095-4dannjjm 5444 15 cats cat NNS cord-023095-4dannjjm 5444 16 . . . cord-023095-4dannjjm 5445 1 The the DT cord-023095-4dannjjm 5445 2 objective objective NN cord-023095-4dannjjm 5445 3 of of IN cord-023095-4dannjjm 5445 4 this this DT cord-023095-4dannjjm 5445 5 study study NN cord-023095-4dannjjm 5445 6 was be VBD cord-023095-4dannjjm 5445 7 to to TO cord-023095-4dannjjm 5445 8 determine determine VB cord-023095-4dannjjm 5445 9 the the DT cord-023095-4dannjjm 5445 10 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 5445 11 of of IN cord-023095-4dannjjm 5445 12 diminazene diminazene NNP cord-023095-4dannjjm 5445 13 diaceturate diaceturate NNP cord-023095-4dannjjm 5445 14 in in IN cord-023095-4dannjjm 5445 15 healthy healthy JJ cord-023095-4dannjjm 5445 16 cats cat NNS cord-023095-4dannjjm 5445 17 . . . cord-023095-4dannjjm 5446 1 Four four CD cord-023095-4dannjjm 5446 2 purpose purpose NN cord-023095-4dannjjm 5446 3 bred breed VBD cord-023095-4dannjjm 5446 4 cats cat NNS cord-023095-4dannjjm 5446 5 with with IN cord-023095-4dannjjm 5446 6 normal normal JJ cord-023095-4dannjjm 5446 7 physical physical JJ cord-023095-4dannjjm 5446 8 examination examination NN cord-023095-4dannjjm 5446 9 , , , cord-023095-4dannjjm 5446 10 CBC CBC NNP cord-023095-4dannjjm 5446 11 , , , cord-023095-4dannjjm 5446 12 chemistry chemistry NN cord-023095-4dannjjm 5446 13 and and CC cord-023095-4dannjjm 5446 14 urinalysis urinalysis NN cord-023095-4dannjjm 5446 15 were be VBD cord-023095-4dannjjm 5446 16 used use VBN cord-023095-4dannjjm 5446 17 . . . cord-023095-4dannjjm 5447 1 A a DT cord-023095-4dannjjm 5447 2 powdered powdered JJ cord-023095-4dannjjm 5447 3 commercial commercial JJ cord-023095-4dannjjm 5447 4 drug drug NN cord-023095-4dannjjm 5447 5 formulation formulation NN cord-023095-4dannjjm 5447 6 ( ( -LRB- cord-023095-4dannjjm 5447 7 Veriben Veriben NNP cord-023095-4dannjjm 5447 8 s s NNP cord-023095-4dannjjm 5447 9 , , , cord-023095-4dannjjm 5447 10 Ceva Ceva NNP cord-023095-4dannjjm 5447 11 Sanet Sanet NNP cord-023095-4dannjjm 5447 12 Animale Animale NNP cord-023095-4dannjjm 5447 13 ) ) -RRB- cord-023095-4dannjjm 5447 14 was be VBD cord-023095-4dannjjm 5447 15 freshly freshly RB cord-023095-4dannjjm 5447 16 reconstituted reconstitute VBN cord-023095-4dannjjm 5447 17 with with IN cord-023095-4dannjjm 5447 18 sterile sterile JJ cord-023095-4dannjjm 5447 19 water water NN cord-023095-4dannjjm 5447 20 to to IN cord-023095-4dannjjm 5447 21 a a DT cord-023095-4dannjjm 5447 22 concentration concentration NN cord-023095-4dannjjm 5447 23 of of IN cord-023095-4dannjjm 5447 24 7 7 CD cord-023095-4dannjjm 5447 25 mg mg NNP cord-023095-4dannjjm 5447 26 / / SYM cord-023095-4dannjjm 5447 27 mL mL NNP cord-023095-4dannjjm 5447 28 prior prior RB cord-023095-4dannjjm 5447 29 to to IN cord-023095-4dannjjm 5447 30 administration administration NN cord-023095-4dannjjm 5447 31 and and CC cord-023095-4dannjjm 5447 32 sterile sterile JJ cord-023095-4dannjjm 5447 33 filtered filter VBN cord-023095-4dannjjm 5447 34 solution solution NN cord-023095-4dannjjm 5447 35 . . . cord-023095-4dannjjm 5448 1 Heparinized heparinize VBN cord-023095-4dannjjm 5448 2 blood blood NN cord-023095-4dannjjm 5448 3 samples sample NNS cord-023095-4dannjjm 5448 4 were be VBD cord-023095-4dannjjm 5448 5 collected collect VBN cord-023095-4dannjjm 5448 6 just just RB cord-023095-4dannjjm 5448 7 before before RB cord-023095-4dannjjm 5448 8 ( ( -LRB- cord-023095-4dannjjm 5448 9 hour hour NN cord-023095-4dannjjm 5448 10 0 0 CD cord-023095-4dannjjm 5448 11 ) ) -RRB- cord-023095-4dannjjm 5448 12 or or CC cord-023095-4dannjjm 5448 13 0.5 0.5 CD cord-023095-4dannjjm 5448 14 , , , cord-023095-4dannjjm 5448 15 1 1 CD cord-023095-4dannjjm 5448 16 , , , cord-023095-4dannjjm 5448 17 2 2 CD cord-023095-4dannjjm 5448 18 , , , cord-023095-4dannjjm 5448 19 4 4 CD cord-023095-4dannjjm 5448 20 , , , cord-023095-4dannjjm 5448 21 8 8 CD cord-023095-4dannjjm 5448 22 , , , cord-023095-4dannjjm 5448 23 12 12 CD cord-023095-4dannjjm 5448 24 , , , cord-023095-4dannjjm 5448 25 18 18 CD cord-023095-4dannjjm 5448 26 , , , cord-023095-4dannjjm 5448 27 24 24 CD cord-023095-4dannjjm 5448 28 , , , cord-023095-4dannjjm 5448 29 36 36 CD cord-023095-4dannjjm 5448 30 , , , cord-023095-4dannjjm 5448 31 48 48 CD cord-023095-4dannjjm 5448 32 , , , cord-023095-4dannjjm 5448 33 72 72 CD cord-023095-4dannjjm 5448 34 , , , cord-023095-4dannjjm 5448 35 120 120 CD cord-023095-4dannjjm 5448 36 , , , cord-023095-4dannjjm 5448 37 and and CC cord-023095-4dannjjm 5448 38 168 168 CD cord-023095-4dannjjm 5448 39 hours hour NNS cord-023095-4dannjjm 5448 40 after after IN cord-023095-4dannjjm 5448 41 intramuscular intramuscular JJ cord-023095-4dannjjm 5448 42 administration administration NN cord-023095-4dannjjm 5448 43 of of IN cord-023095-4dannjjm 5448 44 3 3 CD cord-023095-4dannjjm 5448 45 mg mg NNP cord-023095-4dannjjm 5448 46 / / SYM cord-023095-4dannjjm 5448 47 kg kg NNP cord-023095-4dannjjm 5448 48 ( ( -LRB- cord-023095-4dannjjm 5448 49 1.68 1.68 CD cord-023095-4dannjjm 5448 50 mg mg NNP cord-023095-4dannjjm 5448 51 / / SYM cord-023095-4dannjjm 5448 52 kg kg NNP cord-023095-4dannjjm 5448 53 of of IN cord-023095-4dannjjm 5448 54 diminazene diminazene NNP cord-023095-4dannjjm 5448 55 base base NN cord-023095-4dannjjm 5448 56 ) ) -RRB- cord-023095-4dannjjm 5448 57 diminazene diminazene NNP cord-023095-4dannjjm 5448 58 diaceturate diaceturate NNP cord-023095-4dannjjm 5448 59 . . . cord-023095-4dannjjm 5449 1 The the DT cord-023095-4dannjjm 5449 2 plasma plasma NN cord-023095-4dannjjm 5449 3 was be VBD cord-023095-4dannjjm 5449 4 separated separate VBN cord-023095-4dannjjm 5449 5 by by IN cord-023095-4dannjjm 5449 6 centrifugation centrifugation NN cord-023095-4dannjjm 5449 7 within within IN cord-023095-4dannjjm 5449 8 30 30 CD cord-023095-4dannjjm 5449 9 minutes minute NNS cord-023095-4dannjjm 5449 10 of of IN cord-023095-4dannjjm 5449 11 collection collection NN cord-023095-4dannjjm 5449 12 and and CC cord-023095-4dannjjm 5449 13 frozen frozen JJ cord-023095-4dannjjm 5449 14 ( ( -LRB- cord-023095-4dannjjm 5449 15 À801C À801C NNP cord-023095-4dannjjm 5449 16 ) ) -RRB- cord-023095-4dannjjm 5449 17 until until IN cord-023095-4dannjjm 5449 18 analysis analysis NN cord-023095-4dannjjm 5449 19 . . . cord-023095-4dannjjm 5450 1 Concentrations concentration NNS cord-023095-4dannjjm 5450 2 of of IN cord-023095-4dannjjm 5450 3 diminazene diminazene NNP cord-023095-4dannjjm 5450 4 were be VBD cord-023095-4dannjjm 5450 5 measured measure VBN cord-023095-4dannjjm 5450 6 by by IN cord-023095-4dannjjm 5450 7 HPLC HPLC NNP cord-023095-4dannjjm 5450 8 analysis analysis NN cord-023095-4dannjjm 5450 9 using use VBG cord-023095-4dannjjm 5450 10 UV uv NN cord-023095-4dannjjm 5450 11 absorption absorption NN cord-023095-4dannjjm 5450 12 and and CC cord-023095-4dannjjm 5450 13 ion ion NN cord-023095-4dannjjm 5450 14 - - HYPH cord-023095-4dannjjm 5450 15 pairing pair VBG cord-023095-4dannjjm 5450 16 conditions condition NNS cord-023095-4dannjjm 5450 17 . . . cord-023095-4dannjjm 5451 1 The the DT cord-023095-4dannjjm 5451 2 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 5451 3 profile profile NN cord-023095-4dannjjm 5451 4 was be VBD cord-023095-4dannjjm 5451 5 analyzed analyze VBN cord-023095-4dannjjm 5451 6 using use VBG cord-023095-4dannjjm 5451 7 a a DT cord-023095-4dannjjm 5451 8 simple simple JJ cord-023095-4dannjjm 5451 9 one one CD cord-023095-4dannjjm 5451 10 - - HYPH cord-023095-4dannjjm 5451 11 compartment compartment NN cord-023095-4dannjjm 5451 12 model model NN cord-023095-4dannjjm 5451 13 . . . cord-023095-4dannjjm 5452 1 In in IN cord-023095-4dannjjm 5452 2 these these DT cord-023095-4dannjjm 5452 3 cats cat NNS cord-023095-4dannjjm 5452 4 , , , cord-023095-4dannjjm 5452 5 diminazene diminazene NNP cord-023095-4dannjjm 5452 6 had have VBD cord-023095-4dannjjm 5452 7 a a DT cord-023095-4dannjjm 5452 8 mean mean JJ cord-023095-4dannjjm 5452 9 terminal terminal JJ cord-023095-4dannjjm 5452 10 half half JJ cord-023095-4dannjjm 5452 11 life life NN cord-023095-4dannjjm 5452 12 ( ( -LRB- cord-023095-4dannjjm 5452 13 T T NNP cord-023095-4dannjjm 5452 14 1/2 1/2 CD cord-023095-4dannjjm 5452 15 ) ) -RRB- cord-023095-4dannjjm 5452 16 of of IN cord-023095-4dannjjm 5452 17 1.70 1.70 CD cord-023095-4dannjjm 5452 18 ( ( -LRB- cord-023095-4dannjjm 5452 19 1/-0.29 1/-0.29 CD cord-023095-4dannjjm 5452 20 ) ) -RRB- cord-023095-4dannjjm 5452 21 hrs hrs NN cord-023095-4dannjjm 5452 22 and and CC cord-023095-4dannjjm 5452 23 mean mean VB cord-023095-4dannjjm 5452 24 peak peak NN cord-023095-4dannjjm 5452 25 plasma plasma NN cord-023095-4dannjjm 5452 26 concentration concentration NN cord-023095-4dannjjm 5452 27 ( ( -LRB- cord-023095-4dannjjm 5452 28 C C NNP cord-023095-4dannjjm 5452 29 MAX MAX NNP cord-023095-4dannjjm 5452 30 ) ) -RRB- cord-023095-4dannjjm 5452 31 0.51 0.51 CD cord-023095-4dannjjm 5452 32 ( ( -LRB- cord-023095-4dannjjm 5452 33 1 1 CD cord-023095-4dannjjm 5452 34 / / SYM cord-023095-4dannjjm 5452 35 À à NN cord-023095-4dannjjm 5452 36 0.11 0.11 CD cord-023095-4dannjjm 5452 37 ) ) -RRB- cord-023095-4dannjjm 5453 1 mg mg NNP cord-023095-4dannjjm 5453 2 / / SYM cord-023095-4dannjjm 5453 3 mL. mL. NNP cord-023095-4dannjjm 5454 1 The the DT cord-023095-4dannjjm 5454 2 mean mean JJ cord-023095-4dannjjm 5454 3 residence residence NN cord-023095-4dannjjm 5454 4 time time NN cord-023095-4dannjjm 5454 5 ( ( -LRB- cord-023095-4dannjjm 5454 6 MRT MRT NNP cord-023095-4dannjjm 5454 7 ) ) -RRB- cord-023095-4dannjjm 5454 8 of of IN cord-023095-4dannjjm 5454 9 diminazene diminazene NNP cord-023095-4dannjjm 5454 10 was be VBD cord-023095-4dannjjm 5454 11 2.45 2.45 CD cord-023095-4dannjjm 5454 12 hrs hrs NN cord-023095-4dannjjm 5454 13 ( ( -LRB- cord-023095-4dannjjm 5454 14 1 1 CD cord-023095-4dannjjm 5454 15 / / SYM cord-023095-4dannjjm 5454 16 À0.42 à0.42 NN cord-023095-4dannjjm 5454 17 ) ) -RRB- cord-023095-4dannjjm 5454 18 . . . cord-023095-4dannjjm 5455 1 Systemic systemic JJ cord-023095-4dannjjm 5455 2 clearance clearance NN cord-023095-4dannjjm 5455 3 ( ( -LRB- cord-023095-4dannjjm 5455 4 CL CL NNP cord-023095-4dannjjm 5455 5 / / SYM cord-023095-4dannjjm 5455 6 F F NNP cord-023095-4dannjjm 5455 7 ) ) -RRB- cord-023095-4dannjjm 5455 8 was be VBD cord-023095-4dannjjm 5455 9 1.38 1.38 CD cord-023095-4dannjjm 5455 10 ( ( -LRB- cord-023095-4dannjjm 5455 11 1 1 CD cord-023095-4dannjjm 5455 12 / / SYM cord-023095-4dannjjm 5455 13 À à NN cord-023095-4dannjjm 5455 14 0.26 0.26 CD cord-023095-4dannjjm 5455 15 ) ) -RRB- cord-023095-4dannjjm 5456 1 L L NNP cord-023095-4dannjjm 5456 2 / / SYM cord-023095-4dannjjm 5456 3 kg kg NNP cord-023095-4dannjjm 5456 4 / / SYM cord-023095-4dannjjm 5456 5 hr hr NN cord-023095-4dannjjm 5456 6 . . . cord-023095-4dannjjm 5457 1 The the DT cord-023095-4dannjjm 5457 2 volume volume NN cord-023095-4dannjjm 5457 3 of of IN cord-023095-4dannjjm 5457 4 distribution distribution NN cord-023095-4dannjjm 5457 5 per per IN cord-023095-4dannjjm 5457 6 fraction fraction NN cord-023095-4dannjjm 5457 7 absorbed absorb VBN cord-023095-4dannjjm 5457 8 ( ( -LRB- cord-023095-4dannjjm 5457 9 VD VD NNP cord-023095-4dannjjm 5457 10 / / SYM cord-023095-4dannjjm 5457 11 F F NNP cord-023095-4dannjjm 5457 12 ) ) -RRB- cord-023095-4dannjjm 5457 13 was be VBD cord-023095-4dannjjm 5457 14 3.36 3.36 CD cord-023095-4dannjjm 5457 15 ( ( -LRB- cord-023095-4dannjjm 5457 16 1 1 CD cord-023095-4dannjjm 5457 17 / / SYM cord-023095-4dannjjm 5457 18 À à NN cord-023095-4dannjjm 5457 19 0.72 0.72 CD cord-023095-4dannjjm 5457 20 ) ) -RRB- cord-023095-4dannjjm 5458 1 L L NNP cord-023095-4dannjjm 5458 2 / / SYM cord-023095-4dannjjm 5458 3 kg kg NN cord-023095-4dannjjm 5458 4 . . . cord-023095-4dannjjm 5459 1 A a DT cord-023095-4dannjjm 5459 2 single single JJ cord-023095-4dannjjm 5459 3 intramuscular intramuscular JJ cord-023095-4dannjjm 5459 4 dose dose NN cord-023095-4dannjjm 5459 5 of of IN cord-023095-4dannjjm 5459 6 diminazene diminazene NNP cord-023095-4dannjjm 5459 7 diaceturate diaceturate NNP cord-023095-4dannjjm 5459 8 was be VBD cord-023095-4dannjjm 5459 9 well well RB cord-023095-4dannjjm 5459 10 tolerated tolerate VBN cord-023095-4dannjjm 5459 11 by by IN cord-023095-4dannjjm 5459 12 all all DT cord-023095-4dannjjm 5459 13 4 4 CD cord-023095-4dannjjm 5459 14 cats cat NNS cord-023095-4dannjjm 5459 15 . . . cord-023095-4dannjjm 5460 1 Without without IN cord-023095-4dannjjm 5460 2 knowing know VBG cord-023095-4dannjjm 5460 3 the the DT cord-023095-4dannjjm 5460 4 concentration concentration NN cord-023095-4dannjjm 5460 5 required require VBN cord-023095-4dannjjm 5460 6 to to TO cord-023095-4dannjjm 5460 7 inhibit inhibit VB cord-023095-4dannjjm 5460 8 or or CC cord-023095-4dannjjm 5460 9 kill kill VB cord-023095-4dannjjm 5460 10 Cytauxzoon Cytauxzoon NNP cord-023095-4dannjjm 5460 11 felis felis NN cord-023095-4dannjjm 5460 12 , , , cord-023095-4dannjjm 5460 13 it -PRON- PRP cord-023095-4dannjjm 5460 14 is be VBZ cord-023095-4dannjjm 5460 15 not not RB cord-023095-4dannjjm 5460 16 yet yet RB cord-023095-4dannjjm 5460 17 possible possible JJ cord-023095-4dannjjm 5460 18 to to TO cord-023095-4dannjjm 5460 19 make make VB cord-023095-4dannjjm 5460 20 suggestions suggestion NNS cord-023095-4dannjjm 5460 21 regarding regard VBG cord-023095-4dannjjm 5460 22 optimum optimum JJ cord-023095-4dannjjm 5460 23 dosing dosing NN cord-023095-4dannjjm 5460 24 schedules schedule NNS cord-023095-4dannjjm 5460 25 for for IN cord-023095-4dannjjm 5460 26 this this DT cord-023095-4dannjjm 5460 27 drug drug NN cord-023095-4dannjjm 5460 28 . . . cord-023095-4dannjjm 5461 1 Additional additional JJ cord-023095-4dannjjm 5461 2 toxicology toxicology NN cord-023095-4dannjjm 5461 3 data datum NNS cord-023095-4dannjjm 5461 4 and and CC cord-023095-4dannjjm 5461 5 studies study NNS cord-023095-4dannjjm 5461 6 to to TO cord-023095-4dannjjm 5461 7 assess assess VB cord-023095-4dannjjm 5461 8 clinical clinical JJ cord-023095-4dannjjm 5461 9 efficacy efficacy NN cord-023095-4dannjjm 5461 10 for for IN cord-023095-4dannjjm 5461 11 the the DT cord-023095-4dannjjm 5461 12 treatment treatment NN cord-023095-4dannjjm 5461 13 of of IN cord-023095-4dannjjm 5461 14 cytauxzoonosis cytauxzoonosis NN cord-023095-4dannjjm 5461 15 are be VBP cord-023095-4dannjjm 5461 16 indicated indicate VBN cord-023095-4dannjjm 5461 17 before before IN cord-023095-4dannjjm 5461 18 routine routine JJ cord-023095-4dannjjm 5461 19 clinical clinical JJ cord-023095-4dannjjm 5461 20 use use NN cord-023095-4dannjjm 5461 21 can can MD cord-023095-4dannjjm 5461 22 be be VB cord-023095-4dannjjm 5461 23 considered consider VBN cord-023095-4dannjjm 5461 24 . . . cord-023095-4dannjjm 5462 1 Meloxicam Meloxicam NNP cord-023095-4dannjjm 5462 2 has have VBZ cord-023095-4dannjjm 5462 3 been be VBN cord-023095-4dannjjm 5462 4 shown show VBN cord-023095-4dannjjm 5462 5 to to TO cord-023095-4dannjjm 5462 6 accumulate accumulate VB cord-023095-4dannjjm 5462 7 in in IN cord-023095-4dannjjm 5462 8 areas area NNS cord-023095-4dannjjm 5462 9 of of IN cord-023095-4dannjjm 5462 10 inflammation inflammation NN cord-023095-4dannjjm 5462 11 in in IN cord-023095-4dannjjm 5462 12 both both CC cord-023095-4dannjjm 5462 13 the the DT cord-023095-4dannjjm 5462 14 rat rat NN cord-023095-4dannjjm 5462 15 and and CC cord-023095-4dannjjm 5462 16 human human NN cord-023095-4dannjjm 5462 17 . . . cord-023095-4dannjjm 5463 1 The the DT cord-023095-4dannjjm 5463 2 objective objective NN cord-023095-4dannjjm 5463 3 of of IN cord-023095-4dannjjm 5463 4 this this DT cord-023095-4dannjjm 5463 5 study study NN cord-023095-4dannjjm 5463 6 was be VBD cord-023095-4dannjjm 5463 7 to to TO cord-023095-4dannjjm 5463 8 investigate investigate VB cord-023095-4dannjjm 5463 9 the the DT cord-023095-4dannjjm 5463 10 concentration concentration NN cord-023095-4dannjjm 5463 11 of of IN cord-023095-4dannjjm 5463 12 meloxicam meloxicam NN cord-023095-4dannjjm 5463 13 in in IN cord-023095-4dannjjm 5463 14 synovial synovial JJ cord-023095-4dannjjm 5463 15 fluid fluid NN cord-023095-4dannjjm 5463 16 of of IN cord-023095-4dannjjm 5463 17 inflamed inflamed JJ cord-023095-4dannjjm 5463 18 joints joint NNS cord-023095-4dannjjm 5463 19 versus versus IN cord-023095-4dannjjm 5463 20 that that DT cord-023095-4dannjjm 5463 21 of of IN cord-023095-4dannjjm 5463 22 non non JJ cord-023095-4dannjjm 5463 23 - - JJ cord-023095-4dannjjm 5463 24 inflamed inflamed JJ cord-023095-4dannjjm 5463 25 joints joint NNS cord-023095-4dannjjm 5463 26 in in IN cord-023095-4dannjjm 5463 27 dogs dog NNS cord-023095-4dannjjm 5463 28 . . . cord-023095-4dannjjm 5464 1 Eight eight CD cord-023095-4dannjjm 5464 2 male male JJ cord-023095-4dannjjm 5464 3 dogs dog NNS cord-023095-4dannjjm 5464 4 were be VBD cord-023095-4dannjjm 5464 5 treated treat VBN cord-023095-4dannjjm 5464 6 with with IN cord-023095-4dannjjm 5464 7 0.2 0.2 CD cord-023095-4dannjjm 5464 8 mg mg NN cord-023095-4dannjjm 5464 9 / / SYM cord-023095-4dannjjm 5464 10 kg kg NNS cord-023095-4dannjjm 5464 11 of of IN cord-023095-4dannjjm 5464 12 meloxicam meloxicam NN cord-023095-4dannjjm 5464 13 on on IN cord-023095-4dannjjm 5464 14 Day Day NNP cord-023095-4dannjjm 5464 15 One one CD cord-023095-4dannjjm 5464 16 and and CC cord-023095-4dannjjm 5464 17 0.1 0.1 CD cord-023095-4dannjjm 5464 18 mg mg NNS cord-023095-4dannjjm 5464 19 / / SYM cord-023095-4dannjjm 5464 20 kg kg NNS cord-023095-4dannjjm 5464 21 of of IN cord-023095-4dannjjm 5464 22 meloxicam meloxicam NN cord-023095-4dannjjm 5464 23 on on IN cord-023095-4dannjjm 5464 24 Day Day NNP cord-023095-4dannjjm 5464 25 Two two CD cord-023095-4dannjjm 5464 26 . . . cord-023095-4dannjjm 5465 1 All all DT cord-023095-4dannjjm 5465 2 treatments treatment NNS cord-023095-4dannjjm 5465 3 were be VBD cord-023095-4dannjjm 5465 4 administered administer VBN cord-023095-4dannjjm 5465 5 orally orally RB cord-023095-4dannjjm 5465 6 . . . cord-023095-4dannjjm 5466 1 On on IN cord-023095-4dannjjm 5466 2 Day Day NNP cord-023095-4dannjjm 5466 3 Three three CD cord-023095-4dannjjm 5466 4 reversible reversible JJ cord-023095-4dannjjm 5466 5 acute acute JJ cord-023095-4dannjjm 5466 6 synovitis synovitis NN cord-023095-4dannjjm 5466 7 was be VBD cord-023095-4dannjjm 5466 8 induced induce VBN cord-023095-4dannjjm 5466 9 in in IN cord-023095-4dannjjm 5466 10 one one CD cord-023095-4dannjjm 5466 11 stifle stifle NN cord-023095-4dannjjm 5466 12 by by IN cord-023095-4dannjjm 5466 13 aseptic aseptic JJ cord-023095-4dannjjm 5466 14 , , , cord-023095-4dannjjm 5466 15 intra intra JJ cord-023095-4dannjjm 5466 16 - - JJ cord-023095-4dannjjm 5466 17 articular articular JJ cord-023095-4dannjjm 5466 18 administration administration NN cord-023095-4dannjjm 5466 19 of of IN cord-023095-4dannjjm 5466 20 1 1 CD cord-023095-4dannjjm 5466 21 ml ml NN cord-023095-4dannjjm 5466 22 sodium sodium NN cord-023095-4dannjjm 5466 23 urate urate NN cord-023095-4dannjjm 5466 24 crystal crystal NN cord-023095-4dannjjm 5466 25 suspension suspension NN cord-023095-4dannjjm 5466 26 ( ( -LRB- cord-023095-4dannjjm 5466 27 10 10 CD cord-023095-4dannjjm 5466 28 mg mg NNP cord-023095-4dannjjm 5466 29 / / SYM cord-023095-4dannjjm 5466 30 ml ml NN cord-023095-4dannjjm 5466 31 ) ) -RRB- cord-023095-4dannjjm 5466 32 . . . cord-023095-4dannjjm 5467 1 In in IN cord-023095-4dannjjm 5467 2 four four CD cord-023095-4dannjjm 5467 3 dogs dog NNS cord-023095-4dannjjm 5467 4 synovitis synovitis NNP cord-023095-4dannjjm 5467 5 was be VBD cord-023095-4dannjjm 5467 6 induced induce VBN cord-023095-4dannjjm 5467 7 in in IN cord-023095-4dannjjm 5467 8 the the DT cord-023095-4dannjjm 5467 9 L L NNP cord-023095-4dannjjm 5467 10 stifle stifle NN cord-023095-4dannjjm 5467 11 and and CC cord-023095-4dannjjm 5467 12 in in IN cord-023095-4dannjjm 5467 13 four four CD cord-023095-4dannjjm 5467 14 dogs dog NNS cord-023095-4dannjjm 5467 15 the the DT cord-023095-4dannjjm 5467 16 same same JJ cord-023095-4dannjjm 5467 17 procedure procedure NN cord-023095-4dannjjm 5467 18 was be VBD cord-023095-4dannjjm 5467 19 used use VBN cord-023095-4dannjjm 5467 20 in in IN cord-023095-4dannjjm 5467 21 the the DT cord-023095-4dannjjm 5467 22 R r NN cord-023095-4dannjjm 5467 23 stifle stifle VB cord-023095-4dannjjm 5467 24 . . . cord-023095-4dannjjm 5468 1 In in IN cord-023095-4dannjjm 5468 2 each each DT cord-023095-4dannjjm 5468 3 dog dog NN cord-023095-4dannjjm 5468 4 the the DT cord-023095-4dannjjm 5468 5 stifle stifle NN cord-023095-4dannjjm 5468 6 without without IN cord-023095-4dannjjm 5468 7 induction induction NN cord-023095-4dannjjm 5468 8 of of IN cord-023095-4dannjjm 5468 9 synovitis synovitis NNP cord-023095-4dannjjm 5468 10 served serve VBD cord-023095-4dannjjm 5468 11 as as IN cord-023095-4dannjjm 5468 12 the the DT cord-023095-4dannjjm 5468 13 ' ' `` cord-023095-4dannjjm 5468 14 ' ' `` cord-023095-4dannjjm 5468 15 normal normal JJ cord-023095-4dannjjm 5468 16 ' ' '' cord-023095-4dannjjm 5468 17 ' ' '' cord-023095-4dannjjm 5468 18 joint joint JJ cord-023095-4dannjjm 5468 19 sample sample NN cord-023095-4dannjjm 5468 20 . . . cord-023095-4dannjjm 5469 1 A a DT cord-023095-4dannjjm 5469 2 synovial synovial JJ cord-023095-4dannjjm 5469 3 fluid fluid NN cord-023095-4dannjjm 5469 4 sample sample NN cord-023095-4dannjjm 5469 5 was be VBD cord-023095-4dannjjm 5469 6 collected collect VBN cord-023095-4dannjjm 5469 7 from from IN cord-023095-4dannjjm 5469 8 both both CC cord-023095-4dannjjm 5469 9 the the DT cord-023095-4dannjjm 5469 10 R r NN cord-023095-4dannjjm 5469 11 and and CC cord-023095-4dannjjm 5469 12 L l NN cord-023095-4dannjjm 5469 13 stifle stifle VB cord-023095-4dannjjm 5469 14 of of IN cord-023095-4dannjjm 5469 15 each each DT cord-023095-4dannjjm 5469 16 dog dog NN cord-023095-4dannjjm 5469 17 . . . cord-023095-4dannjjm 5470 1 Sample sample NN cord-023095-4dannjjm 5470 2 collection collection NN cord-023095-4dannjjm 5470 3 occurred occur VBD cord-023095-4dannjjm 5470 4 eight eight CD cord-023095-4dannjjm 5470 5 hours hour NNS cord-023095-4dannjjm 5470 6 after after IN cord-023095-4dannjjm 5470 7 administration administration NN cord-023095-4dannjjm 5470 8 of of IN cord-023095-4dannjjm 5470 9 sodium sodium NN cord-023095-4dannjjm 5470 10 urate urate NN cord-023095-4dannjjm 5470 11 and and CC cord-023095-4dannjjm 5470 12 twenty twenty CD cord-023095-4dannjjm 5470 13 four four CD cord-023095-4dannjjm 5470 14 hours hour NNS cord-023095-4dannjjm 5470 15 after after IN cord-023095-4dannjjm 5470 16 the the DT cord-023095-4dannjjm 5470 17 last last JJ cord-023095-4dannjjm 5470 18 administration administration NN cord-023095-4dannjjm 5470 19 of of IN cord-023095-4dannjjm 5470 20 meloxicam meloxicam NNP cord-023095-4dannjjm 5470 21 . . . cord-023095-4dannjjm 5471 1 Synovial Synovial NNP cord-023095-4dannjjm 5471 2 meloxicam meloxicam NN cord-023095-4dannjjm 5471 3 concentration concentration NN cord-023095-4dannjjm 5471 4 was be VBD cord-023095-4dannjjm 5471 5 analysed analyse VBN cord-023095-4dannjjm 5471 6 using use VBG cord-023095-4dannjjm 5471 7 High High NNP cord-023095-4dannjjm 5471 8 Performance Performance NNP cord-023095-4dannjjm 5471 9 Liquid Liquid NNP cord-023095-4dannjjm 5471 10 Chromatography Chromatography NNP cord-023095-4dannjjm 5471 11 - - HYPH cord-023095-4dannjjm 5471 12 Mass Mass NNP cord-023095-4dannjjm 5471 13 Spectrometry Spectrometry NNP cord-023095-4dannjjm 5471 14 ( ( -LRB- cord-023095-4dannjjm 5471 15 HPLC/ HPLC/ NNP cord-023095-4dannjjm 5471 16 MS MS NNP cord-023095-4dannjjm 5471 17 - - HYPH cord-023095-4dannjjm 5471 18 MS MS NNP cord-023095-4dannjjm 5471 19 ) ) -RRB- cord-023095-4dannjjm 5471 20 . . . cord-023095-4dannjjm 5472 1 The the DT cord-023095-4dannjjm 5472 2 concentration concentration NN cord-023095-4dannjjm 5472 3 of of IN cord-023095-4dannjjm 5472 4 meloxicam meloxicam NN cord-023095-4dannjjm 5472 5 in in IN cord-023095-4dannjjm 5472 6 the the DT cord-023095-4dannjjm 5472 7 inflamed inflamed JJ cord-023095-4dannjjm 5472 8 versus versus IN cord-023095-4dannjjm 5472 9 non non JJ cord-023095-4dannjjm 5472 10 - - JJ cord-023095-4dannjjm 5472 11 inflamed inflamed JJ cord-023095-4dannjjm 5472 12 joint joint NN cord-023095-4dannjjm 5472 13 in in IN cord-023095-4dannjjm 5472 14 each each DT cord-023095-4dannjjm 5472 15 dog dog NN cord-023095-4dannjjm 5472 16 was be VBD cord-023095-4dannjjm 5472 17 compared compare VBN cord-023095-4dannjjm 5472 18 using use VBG cord-023095-4dannjjm 5472 19 the the DT cord-023095-4dannjjm 5472 20 paired paired JJ cord-023095-4dannjjm 5472 21 t t NN cord-023095-4dannjjm 5472 22 - - HYPH cord-023095-4dannjjm 5472 23 test test NN cord-023095-4dannjjm 5472 24 . . . cord-023095-4dannjjm 5473 1 The the DT cord-023095-4dannjjm 5473 2 results result NNS cord-023095-4dannjjm 5473 3 indicate indicate VBP cord-023095-4dannjjm 5473 4 that that IN cord-023095-4dannjjm 5473 5 meloxicam meloxicam NNP cord-023095-4dannjjm 5473 6 preferentially preferentially RB cord-023095-4dannjjm 5473 7 accumulates accumulate VBZ cord-023095-4dannjjm 5473 8 in in IN cord-023095-4dannjjm 5473 9 inflamed inflamed JJ cord-023095-4dannjjm 5473 10 joints joint NNS cord-023095-4dannjjm 5473 11 in in IN cord-023095-4dannjjm 5473 12 the the DT cord-023095-4dannjjm 5473 13 dog dog NN cord-023095-4dannjjm 5473 14 as as IN cord-023095-4dannjjm 5473 15 meloxicam meloxicam NNP cord-023095-4dannjjm 5473 16 concentrations concentration NNS cord-023095-4dannjjm 5473 17 are be VBP cord-023095-4dannjjm 5473 18 statistically statistically RB cord-023095-4dannjjm 5473 19 significantly significantly RB cord-023095-4dannjjm 5473 20 higher high JJR cord-023095-4dannjjm 5473 21 in in IN cord-023095-4dannjjm 5473 22 inflamed inflamed JJ cord-023095-4dannjjm 5473 23 joints joint NNS cord-023095-4dannjjm 5473 24 than than IN cord-023095-4dannjjm 5473 25 in in IN cord-023095-4dannjjm 5473 26 non non JJ cord-023095-4dannjjm 5473 27 - - JJ cord-023095-4dannjjm 5473 28 inflamed inflamed JJ cord-023095-4dannjjm 5473 29 joints joint NNS cord-023095-4dannjjm 5473 30 . . . cord-023095-4dannjjm 5474 1 No no DT cord-023095-4dannjjm 5474 2 national national JJ cord-023095-4dannjjm 5474 3 surveillance surveillance NN cord-023095-4dannjjm 5474 4 system system NN cord-023095-4dannjjm 5474 5 exists exist VBZ cord-023095-4dannjjm 5474 6 for for IN cord-023095-4dannjjm 5474 7 monitoring monitor VBG cord-023095-4dannjjm 5474 8 emergent emergent JJ cord-023095-4dannjjm 5474 9 resistance resistance NN cord-023095-4dannjjm 5474 10 in in IN cord-023095-4dannjjm 5474 11 companion companion NN cord-023095-4dannjjm 5474 12 animals animal NNS cord-023095-4dannjjm 5474 13 . . . cord-023095-4dannjjm 5475 1 However however RB cord-023095-4dannjjm 5475 2 , , , cord-023095-4dannjjm 5475 3 E. E. NNP cord-023095-4dannjjm 5475 4 coli coli VBZ cord-023095-4dannjjm 5475 5 resistance resistance NN cord-023095-4dannjjm 5475 6 is be VBZ cord-023095-4dannjjm 5475 7 an an DT cord-023095-4dannjjm 5475 8 increasing increase VBG cord-023095-4dannjjm 5475 9 therapeutic therapeutic JJ cord-023095-4dannjjm 5475 10 and and CC cord-023095-4dannjjm 5475 11 public public JJ cord-023095-4dannjjm 5475 12 health health NN cord-023095-4dannjjm 5475 13 concern concern NN cord-023095-4dannjjm 5475 14 in in IN cord-023095-4dannjjm 5475 15 these these DT cord-023095-4dannjjm 5475 16 in in IN cord-023095-4dannjjm 5475 17 dogs dog NNS cord-023095-4dannjjm 5475 18 and and CC cord-023095-4dannjjm 5475 19 cats cat NNS cord-023095-4dannjjm 5475 20 . . . cord-023095-4dannjjm 5476 1 The the DT cord-023095-4dannjjm 5476 2 purpose purpose NN cord-023095-4dannjjm 5476 3 of of IN cord-023095-4dannjjm 5476 4 this this DT cord-023095-4dannjjm 5476 5 study study NN cord-023095-4dannjjm 5476 6 was be VBD cord-023095-4dannjjm 5476 7 to to TO cord-023095-4dannjjm 5476 8 describe describe VB cord-023095-4dannjjm 5476 9 current current JJ cord-023095-4dannjjm 5476 10 resistance resistance NN cord-023095-4dannjjm 5476 11 patterns pattern NNS cord-023095-4dannjjm 5476 12 of of IN cord-023095-4dannjjm 5476 13 canine canine JJ cord-023095-4dannjjm 5476 14 and and CC cord-023095-4dannjjm 5476 15 feline feline JJ cord-023095-4dannjjm 5476 16 pathogenic pathogenic JJ cord-023095-4dannjjm 5476 17 E. E. NNP cord-023095-4dannjjm 5476 18 coli coli NNS cord-023095-4dannjjm 5476 19 throughout throughout IN cord-023095-4dannjjm 5476 20 the the DT cord-023095-4dannjjm 5476 21 United United NNP cord-023095-4dannjjm 5476 22 States States NNP cord-023095-4dannjjm 5476 23 and and CC cord-023095-4dannjjm 5476 24 identify identify VB cord-023095-4dannjjm 5476 25 risk risk NN cord-023095-4dannjjm 5476 26 factors factor NNS cord-023095-4dannjjm 5476 27 of of IN cord-023095-4dannjjm 5476 28 antimicrobial antimicrobial JJ cord-023095-4dannjjm 5476 29 resistance resistance NN cord-023095-4dannjjm 5476 30 . . . cord-023095-4dannjjm 5477 1 Isolates Isolates NNP cord-023095-4dannjjm 5477 2 ( ( -LRB- cord-023095-4dannjjm 5477 3 n n NN cord-023095-4dannjjm 5477 4 5 5 CD cord-023095-4dannjjm 5477 5 1512 1512 CD cord-023095-4dannjjm 5477 6 ) ) -RRB- cord-023095-4dannjjm 5477 7 of of IN cord-023095-4dannjjm 5477 8 clinical clinical JJ cord-023095-4dannjjm 5477 9 E. E. NNP cord-023095-4dannjjm 5477 10 coli coli NNS cord-023095-4dannjjm 5477 11 collected collect VBN cord-023095-4dannjjm 5477 12 from from IN cord-023095-4dannjjm 5477 13 dogs dog NNS cord-023095-4dannjjm 5477 14 or or CC cord-023095-4dannjjm 5477 15 cats cat NNS cord-023095-4dannjjm 5477 16 from from IN cord-023095-4dannjjm 5477 17 May May NNP cord-023095-4dannjjm 5477 18 2008 2008 CD cord-023095-4dannjjm 5477 19 through through IN cord-023095-4dannjjm 5477 20 May May NNP cord-023095-4dannjjm 5477 21 2010 2010 CD cord-023095-4dannjjm 5477 22 located locate VBN cord-023095-4dannjjm 5477 23 in in IN cord-023095-4dannjjm 5477 24 6 6 CD cord-023095-4dannjjm 5477 25 different different JJ cord-023095-4dannjjm 5477 26 regions region NNS cord-023095-4dannjjm 5477 27 . . . cord-023095-4dannjjm 5478 1 Susceptibility susceptibility NN cord-023095-4dannjjm 5478 2 was be VBD cord-023095-4dannjjm 5478 3 determined determine VBN cord-023095-4dannjjm 5478 4 to to IN cord-023095-4dannjjm 5478 5 15 15 CD cord-023095-4dannjjm 5478 6 drugs drug NNS cord-023095-4dannjjm 5478 7 ( ( -LRB- cord-023095-4dannjjm 5478 8 6 6 CD cord-023095-4dannjjm 5478 9 drug drug NN cord-023095-4dannjjm 5478 10 classes class NNS cord-023095-4dannjjm 5478 11 ) ) -RRB- cord-023095-4dannjjm 5478 12 by by IN cord-023095-4dannjjm 5478 13 broth broth NN cord-023095-4dannjjm 5478 14 microdilution microdilution NN cord-023095-4dannjjm 5478 15 methods method NNS cord-023095-4dannjjm 5478 16 . . . cord-023095-4dannjjm 5479 1 Pharmacodyamaic Pharmacodyamaic NNP cord-023095-4dannjjm 5479 2 statistics statistic NNS cord-023095-4dannjjm 5479 3 were be VBD cord-023095-4dannjjm 5479 4 described describe VBN cord-023095-4dannjjm 5479 5 regionally regionally RB cord-023095-4dannjjm 5479 6 . . . cord-023095-4dannjjm 5480 1 Phenotypes phenotype NNS cord-023095-4dannjjm 5480 2 were be VBD cord-023095-4dannjjm 5480 3 determined determine VBN cord-023095-4dannjjm 5480 4 and and CC cord-023095-4dannjjm 5480 5 type type NN cord-023095-4dannjjm 5480 6 of of IN cord-023095-4dannjjm 5480 7 resistance resistance NN cord-023095-4dannjjm 5480 8 was be VBD cord-023095-4dannjjm 5480 9 based base VBN cord-023095-4dannjjm 5480 10 on on IN cord-023095-4dannjjm 5480 11 the the DT cord-023095-4dannjjm 5480 12 number number NN cord-023095-4dannjjm 5480 13 of of IN cord-023095-4dannjjm 5480 14 drug drug NN cord-023095-4dannjjm 5480 15 classes class NNS cord-023095-4dannjjm 5480 16 to to TO cord-023095-4dannjjm 5480 17 which which WDT cord-023095-4dannjjm 5480 18 resistance resistance NN cord-023095-4dannjjm 5480 19 was be VBD cord-023095-4dannjjm 5480 20 expressed express VBN cord-023095-4dannjjm 5480 21 : : : cord-023095-4dannjjm 5480 22 none none NN cord-023095-4dannjjm 5480 23 ( ( -LRB- cord-023095-4dannjjm 5480 24 NDR NDR NNP cord-023095-4dannjjm 5480 25 ) ) -RRB- cord-023095-4dannjjm 5480 26 , , , cord-023095-4dannjjm 5480 27 single single JJ cord-023095-4dannjjm 5480 28 ( ( -LRB- cord-023095-4dannjjm 5480 29 SDR SDR NNP cord-023095-4dannjjm 5480 30 ) ) -RRB- cord-023095-4dannjjm 5480 31 and and CC cord-023095-4dannjjm 5480 32 multi multi JJ cord-023095-4dannjjm 5480 33 ( ( -LRB- cord-023095-4dannjjm 5480 34 MDR MDR NNP cord-023095-4dannjjm 5480 35 ) ) -RRB- cord-023095-4dannjjm 5480 36 . . . cord-023095-4dannjjm 5481 1 The the DT cord-023095-4dannjjm 5481 2 majority majority NN cord-023095-4dannjjm 5481 3 of of IN cord-023095-4dannjjm 5481 4 isolates isolate NNS cord-023095-4dannjjm 5481 5 were be VBD cord-023095-4dannjjm 5481 6 from from IN cord-023095-4dannjjm 5481 7 urinary urinary JJ cord-023095-4dannjjm 5481 8 tract tract NN cord-023095-4dannjjm 5481 9 ( ( -LRB- cord-023095-4dannjjm 5481 10 71.5 71.5 CD cord-023095-4dannjjm 5481 11 % % NN cord-023095-4dannjjm 5481 12 ) ) -RRB- cord-023095-4dannjjm 5481 13 and and CC cord-023095-4dannjjm 5481 14 dogs dog NNS cord-023095-4dannjjm 5481 15 ( ( -LRB- cord-023095-4dannjjm 5481 16 75.7 75.7 CD cord-023095-4dannjjm 5481 17 % % NN cord-023095-4dannjjm 5481 18 ) ) -RRB- cord-023095-4dannjjm 5481 19 . . . cord-023095-4dannjjm 5482 1 The the DT cord-023095-4dannjjm 5482 2 proportion proportion NN cord-023095-4dannjjm 5482 3 of of IN cord-023095-4dannjjm 5482 4 resistance resistance NN cord-023095-4dannjjm 5482 5 type type NN cord-023095-4dannjjm 5482 6 for for IN cord-023095-4dannjjm 5482 7 each each DT cord-023095-4dannjjm 5482 8 drug drug NN cord-023095-4dannjjm 5482 9 was be VBD cord-023095-4dannjjm 5482 10 : : : cord-023095-4dannjjm 5482 11 NDR NDR NNP cord-023095-4dannjjm 5482 12 ( ( -LRB- cord-023095-4dannjjm 5482 13 17.5 17.5 CD cord-023095-4dannjjm 5482 14 % % NN cord-023095-4dannjjm 5482 15 ) ) -RRB- cord-023095-4dannjjm 5482 16 , , , cord-023095-4dannjjm 5482 17 SDR SDR NNP cord-023095-4dannjjm 5482 18 ( ( -LRB- cord-023095-4dannjjm 5482 19 56.4 56.4 CD cord-023095-4dannjjm 5482 20 % % NN cord-023095-4dannjjm 5482 21 ) ) -RRB- cord-023095-4dannjjm 5482 22 and and CC cord-023095-4dannjjm 5482 23 MDR MDR NNP cord-023095-4dannjjm 5482 24 ( ( -LRB- cord-023095-4dannjjm 5482 25 26.12 26.12 CD cord-023095-4dannjjm 5482 26 % % NN cord-023095-4dannjjm 5482 27 ) ) -RRB- cord-023095-4dannjjm 5482 28 . . . cord-023095-4dannjjm 5483 1 The the DT cord-023095-4dannjjm 5483 2 proportion proportion NN cord-023095-4dannjjm 5483 3 of of IN cord-023095-4dannjjm 5483 4 MDR MDR NNP cord-023095-4dannjjm 5483 5 was be VBD cord-023095-4dannjjm 5483 6 greatest great JJS cord-023095-4dannjjm 5483 7 in in IN cord-023095-4dannjjm 5483 8 the the DT cord-023095-4dannjjm 5483 9 Southwest Southwest NNP cord-023095-4dannjjm 5483 10 ( ( -LRB- cord-023095-4dannjjm 5483 11 25.29 25.29 CD cord-023095-4dannjjm 5483 12 % % NN cord-023095-4dannjjm 5483 13 ) ) -RRB- cord-023095-4dannjjm 5483 14 and and CC cord-023095-4dannjjm 5483 15 least least JJS cord-023095-4dannjjm 5483 16 in in IN cord-023095-4dannjjm 5483 17 the the DT cord-023095-4dannjjm 5483 18 Northwest Northwest NNP cord-023095-4dannjjm 5483 19 ( ( -LRB- cord-023095-4dannjjm 5483 20 9.19 9.19 CD cord-023095-4dannjjm 5483 21 % % NN cord-023095-4dannjjm 5483 22 ) ) -RRB- cord-023095-4dannjjm 5484 1 ( ( -LRB- cord-023095-4dannjjm 5484 2 P p NN cord-023095-4dannjjm 5484 3 o o NN cord-023095-4dannjjm 5484 4 0.05 0.05 CD cord-023095-4dannjjm 5484 5 ) ) -RRB- cord-023095-4dannjjm 5484 6 . . . cord-023095-4dannjjm 5485 1 For for IN cord-023095-4dannjjm 5485 2 all all DT cord-023095-4dannjjm 5485 3 regions region NNS cord-023095-4dannjjm 5485 4 , , , cord-023095-4dannjjm 5485 5 the the DT cord-023095-4dannjjm 5485 6 proportion proportion NN cord-023095-4dannjjm 5485 7 of of IN cord-023095-4dannjjm 5485 8 resistance resistance NN cord-023095-4dannjjm 5485 9 was be VBD cord-023095-4dannjjm 5485 10 : : : cord-023095-4dannjjm 5485 11 cephalothin cephalothin NNP cord-023095-4dannjjm 5485 12 ( ( -LRB- cord-023095-4dannjjm 5485 13 CPH CPH NNP cord-023095-4dannjjm 5485 14 , , , cord-023095-4dannjjm 5485 15 65.2 65.2 CD cord-023095-4dannjjm 5485 16 % % NN cord-023095-4dannjjm 5485 17 ) ) -RRB- cord-023095-4dannjjm 5485 18 4 4 CD cord-023095-4dannjjm 5485 19 amoxicillin amoxicillin NNP cord-023095-4dannjjm 5485 20 - - HYPH cord-023095-4dannjjm 5485 21 clavulanic clavulanic NNP cord-023095-4dannjjm 5485 22 acid acid NN cord-023095-4dannjjm 5485 23 ( ( -LRB- cord-023095-4dannjjm 5485 24 AMX AMX NNP cord-023095-4dannjjm 5485 25 , , , cord-023095-4dannjjm 5485 26 59.4 59.4 CD cord-023095-4dannjjm 5485 27 % % NN cord-023095-4dannjjm 5485 28 ) ) -RRB- cord-023095-4dannjjm 5485 29 , , , cord-023095-4dannjjm 5485 30 ampicillin ampicillin NN cord-023095-4dannjjm 5485 31 ( ( -LRB- cord-023095-4dannjjm 5485 32 AMP amp NN cord-023095-4dannjjm 5485 33 , , , cord-023095-4dannjjm 5485 34 52.9 52.9 CD cord-023095-4dannjjm 5485 35 % % NN cord-023095-4dannjjm 5485 36 ) ) -RRB- cord-023095-4dannjjm 5485 37 , , , cord-023095-4dannjjm 5485 38 tricarcillin tricarcillin NNP cord-023095-4dannjjm 5485 39 - - HYPH cord-023095-4dannjjm 5485 40 clavulanic clavulanic NN cord-023095-4dannjjm 5485 41 acid acid NN cord-023095-4dannjjm 5486 1 ( ( -LRB- cord-023095-4dannjjm 5486 2 TCX TCX NNP cord-023095-4dannjjm 5486 3 , , , cord-023095-4dannjjm 5486 4 21.8 21.8 CD cord-023095-4dannjjm 5486 5 % % NN cord-023095-4dannjjm 5486 6 ) ) -RRB- cord-023095-4dannjjm 5486 7 , , , cord-023095-4dannjjm 5486 8 doxycyline doxycyline JJ cord-023095-4dannjjm 5486 9 ( ( -LRB- cord-023095-4dannjjm 5486 10 DXY DXY NNP cord-023095-4dannjjm 5486 11 , , , cord-023095-4dannjjm 5486 12 15.9 15.9 CD cord-023095-4dannjjm 5486 13 % % NN cord-023095-4dannjjm 5486 14 ) ) -RRB- cord-023095-4dannjjm 5486 15 4 4 CD cord-023095-4dannjjm 5486 16 cefoxitin cefoxitin NNS cord-023095-4dannjjm 5486 17 ( ( -LRB- cord-023095-4dannjjm 5486 18 CFX CFX NNP cord-023095-4dannjjm 5486 19 , , , cord-023095-4dannjjm 5486 20 15.2 15.2 CD cord-023095-4dannjjm 5486 21 % % NN cord-023095-4dannjjm 5486 22 ) ) -RRB- cord-023095-4dannjjm 5486 23 , , , cord-023095-4dannjjm 5486 24 cefpodoxime cefpodoxime FW cord-023095-4dannjjm 5486 25 ( ( -LRB- cord-023095-4dannjjm 5486 26 CPX CPX NNP cord-023095-4dannjjm 5486 27 , , , cord-023095-4dannjjm 5486 28 13.7 13.7 CD cord-023095-4dannjjm 5486 29 % % NN cord-023095-4dannjjm 5486 30 ) ) -RRB- cord-023095-4dannjjm 5486 31 , , , cord-023095-4dannjjm 5486 32 chloramphenicol chloramphenicol NNP cord-023095-4dannjjm 5486 33 ( ( -LRB- cord-023095-4dannjjm 5486 34 CHP CHP NNP cord-023095-4dannjjm 5486 35 , , , cord-023095-4dannjjm 5486 36 13.2 13.2 CD cord-023095-4dannjjm 5486 37 % % NN cord-023095-4dannjjm 5486 38 ) ) -RRB- cord-023095-4dannjjm 5486 39 , , , cord-023095-4dannjjm 5486 40 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 5486 41 ( ( -LRB- cord-023095-4dannjjm 5486 42 ENR ENR NNP cord-023095-4dannjjm 5486 43 , , , cord-023095-4dannjjm 5486 44 13.0 13.0 CD cord-023095-4dannjjm 5486 45 % % NN cord-023095-4dannjjm 5486 46 ) ) -RRB- cord-023095-4dannjjm 5486 47 , , , cord-023095-4dannjjm 5486 48 ciprofloxacin ciprofloxacin NNP cord-023095-4dannjjm 5486 49 ( ( -LRB- cord-023095-4dannjjm 5486 50 CIF,12.3 CIF,12.3 NNP cord-023095-4dannjjm 5486 51 % % NN cord-023095-4dannjjm 5486 52 ) ) -RRB- cord-023095-4dannjjm 5486 53 , , , cord-023095-4dannjjm 5486 54 trimethoprim trimethoprim NNP cord-023095-4dannjjm 5486 55 - - HYPH cord-023095-4dannjjm 5486 56 sulfamethoxazole sulfamethoxazole NNP cord-023095-4dannjjm 5486 57 ( ( -LRB- cord-023095-4dannjjm 5486 58 TMX TMX NNP cord-023095-4dannjjm 5486 59 , , , cord-023095-4dannjjm 5486 60 10.7 10.7 CD cord-023095-4dannjjm 5486 61 % % NN cord-023095-4dannjjm 5486 62 ) ) -RRB- cord-023095-4dannjjm 5486 63 , , , cord-023095-4dannjjm 5486 64 ceftazidime(CFZ ceftazidime(CFZ '' cord-023095-4dannjjm 5486 65 , , , cord-023095-4dannjjm 5486 66 10.0 10.0 CD cord-023095-4dannjjm 5486 67 % % NN cord-023095-4dannjjm 5486 68 ) ) -RRB- cord-023095-4dannjjm 5486 69 , , , cord-023095-4dannjjm 5486 70 gentamicin gentamicin FW cord-023095-4dannjjm 5486 71 ( ( -LRB- cord-023095-4dannjjm 5486 72 GTM GTM NNP cord-023095-4dannjjm 5486 73 , , , cord-023095-4dannjjm 5486 74 10.0 10.0 CD cord-023095-4dannjjm 5486 75 % % NN cord-023095-4dannjjm 5486 76 ) ) -RRB- cord-023095-4dannjjm 5486 77 , , , cord-023095-4dannjjm 5486 78 cefotaxime cefotaxime NNP cord-023095-4dannjjm 5486 79 ( ( -LRB- cord-023095-4dannjjm 5486 80 CFT CFT NNP cord-023095-4dannjjm 5486 81 , , , cord-023095-4dannjjm 5486 82 9.2 9.2 CD cord-023095-4dannjjm 5486 83 % % NN cord-023095-4dannjjm 5486 84 ) ) -RRB- cord-023095-4dannjjm 5486 85 4 4 CD cord-023095-4dannjjm 5486 86 meropenem meropenem NNS cord-023095-4dannjjm 5486 87 ( ( -LRB- cord-023095-4dannjjm 5486 88 1.1 1.1 CD cord-023095-4dannjjm 5486 89 % % NN cord-023095-4dannjjm 5486 90 ) ) -RRB- cord-023095-4dannjjm 5486 91 ( ( -LRB- cord-023095-4dannjjm 5486 92 P p NN cord-023095-4dannjjm 5486 93 o o NN cord-023095-4dannjjm 5486 94 0.05 0.05 CD cord-023095-4dannjjm 5486 95 ) ) -RRB- cord-023095-4dannjjm 5486 96 . . . cord-023095-4dannjjm 5487 1 The the DT cord-023095-4dannjjm 5487 2 MIC MIC NNP cord-023095-4dannjjm 5487 3 90 90 CD cord-023095-4dannjjm 5487 4 exceeded exceed VBD cord-023095-4dannjjm 5487 5 the the DT cord-023095-4dannjjm 5487 6 resistant resistant JJ cord-023095-4dannjjm 5487 7 breakpoint breakpoint NN cord-023095-4dannjjm 5487 8 for for IN cord-023095-4dannjjm 5487 9 AMP AMP NNP cord-023095-4dannjjm 5487 10 , , , cord-023095-4dannjjm 5487 11 AMX AMX NNP cord-023095-4dannjjm 5487 12 , , , cord-023095-4dannjjm 5487 13 CPX CPX NNP cord-023095-4dannjjm 5487 14 , , , cord-023095-4dannjjm 5487 15 CPH CPH NNP cord-023095-4dannjjm 5487 16 , , , cord-023095-4dannjjm 5487 17 CIF CIF NNP cord-023095-4dannjjm 5487 18 , , , cord-023095-4dannjjm 5487 19 CFX CFX NNP cord-023095-4dannjjm 5487 20 , , , cord-023095-4dannjjm 5487 21 DXY DXY NNP cord-023095-4dannjjm 5487 22 and and CC cord-023095-4dannjjm 5487 23 ENR ENR NNP cord-023095-4dannjjm 5487 24 whereas whereas IN cord-023095-4dannjjm 5487 25 MIC MIC NNP cord-023095-4dannjjm 5487 26 50 50 CD cord-023095-4dannjjm 5487 27 did do VBD cord-023095-4dannjjm 5487 28 not not RB cord-023095-4dannjjm 5487 29 surpass surpass VB cord-023095-4dannjjm 5487 30 the the DT cord-023095-4dannjjm 5487 31 susceptible susceptible JJ cord-023095-4dannjjm 5487 32 breakpoint breakpoint NN cord-023095-4dannjjm 5487 33 . . . cord-023095-4dannjjm 5488 1 Beta beta NN cord-023095-4dannjjm 5488 2 - - HYPH cord-023095-4dannjjm 5488 3 lactams lactam NNS cord-023095-4dannjjm 5488 4 ( ( -LRB- cord-023095-4dannjjm 5488 5 96.37 96.37 CD cord-023095-4dannjjm 5488 6 % % NN cord-023095-4dannjjm 5488 7 ) ) -RRB- cord-023095-4dannjjm 5488 8 was be VBD cord-023095-4dannjjm 5488 9 the the DT cord-023095-4dannjjm 5488 10 most most JJS cord-023095-4dannjjm 5488 11 and and CC cord-023095-4dannjjm 5488 12 aminoglycosides aminoglycoside NNS cord-023095-4dannjjm 5488 13 the the DT cord-023095-4dannjjm 5488 14 least least JJS cord-023095-4dannjjm 5488 15 ( ( -LRB- cord-023095-4dannjjm 5488 16 0.12 0.12 CD cord-023095-4dannjjm 5488 17 % % NN cord-023095-4dannjjm 5488 18 ) ) -RRB- cord-023095-4dannjjm 5488 19 SDR SDR NNP cord-023095-4dannjjm 5488 20 . . . cord-023095-4dannjjm 5489 1 The the DT cord-023095-4dannjjm 5489 2 drug drug NN cord-023095-4dannjjm 5489 3 class class NN cord-023095-4dannjjm 5489 4 most most RBS cord-023095-4dannjjm 5489 5 frequently frequently RB cord-023095-4dannjjm 5489 6 involved involve VBN cord-023095-4dannjjm 5489 7 in in IN cord-023095-4dannjjm 5489 8 MDR MDR NNP cord-023095-4dannjjm 5489 9 was be VBD cord-023095-4dannjjm 5489 10 beta beta NN cord-023095-4dannjjm 5489 11 - - HYPH cord-023095-4dannjjm 5489 12 lactams lactam NNS cord-023095-4dannjjm 5489 13 ( ( -LRB- cord-023095-4dannjjm 5489 14 97.72 97.72 CD cord-023095-4dannjjm 5489 15 % % NN cord-023095-4dannjjm 5489 16 ) ) -RRB- cord-023095-4dannjjm 5489 17 and and CC cord-023095-4dannjjm 5489 18 least least JJS cord-023095-4dannjjm 5489 19 , , , cord-023095-4dannjjm 5489 20 GEN GEN NNP cord-023095-4dannjjm 5489 21 ( ( -LRB- cord-023095-4dannjjm 5489 22 30.13 30.13 CD cord-023095-4dannjjm 5489 23 % % NN cord-023095-4dannjjm 5489 24 ) ) -RRB- cord-023095-4dannjjm 5489 25 . . . cord-023095-4dannjjm 5490 1 Resistance resistance NN cord-023095-4dannjjm 5490 2 differs differ VBZ cord-023095-4dannjjm 5490 3 regionally regionally RB cord-023095-4dannjjm 5490 4 , , , cord-023095-4dannjjm 5490 5 being be VBG cord-023095-4dannjjm 5490 6 greatest great JJS cord-023095-4dannjjm 5490 7 in in IN cord-023095-4dannjjm 5490 8 the the DT cord-023095-4dannjjm 5490 9 Southwest Southwest NNP cord-023095-4dannjjm 5490 10 . . . cord-023095-4dannjjm 5491 1 CPH CPH NNP cord-023095-4dannjjm 5491 2 is be VBZ cord-023095-4dannjjm 5491 3 the the DT cord-023095-4dannjjm 5491 4 most most JJS cord-023095-4dannjjm 5491 5 and and CC cord-023095-4dannjjm 5491 6 meropenam meropenam NNP cord-023095-4dannjjm 5491 7 is be VBZ cord-023095-4dannjjm 5491 8 the the DT cord-023095-4dannjjm 5491 9 drug drug NN cord-023095-4dannjjm 5491 10 least least JJS cord-023095-4dannjjm 5491 11 associated associate VBN cord-023095-4dannjjm 5491 12 with with IN cord-023095-4dannjjm 5491 13 resistance resistance NN cord-023095-4dannjjm 5491 14 ; ; : cord-023095-4dannjjm 5491 15 these these DT cord-023095-4dannjjm 5491 16 patterns pattern NNS cord-023095-4dannjjm 5491 17 are be VBP cord-023095-4dannjjm 5491 18 consistent consistent JJ cord-023095-4dannjjm 5491 19 with with IN cord-023095-4dannjjm 5491 20 current current JJ cord-023095-4dannjjm 5491 21 drugs drug NNS cord-023095-4dannjjm 5491 22 used use VBN cord-023095-4dannjjm 5491 23 by by IN cord-023095-4dannjjm 5491 24 veterinarians veterinarian NNS cord-023095-4dannjjm 5491 25 . . . cord-023095-4dannjjm 5492 1 The the DT cord-023095-4dannjjm 5492 2 fluoroquinolones fluoroquinolone NNS cord-023095-4dannjjm 5492 3 ( ( -LRB- cord-023095-4dannjjm 5492 4 FQs fq NNS cord-023095-4dannjjm 5492 5 ) ) -RRB- cord-023095-4dannjjm 5492 6 are be VBP cord-023095-4dannjjm 5492 7 common common JJ cord-023095-4dannjjm 5492 8 choices choice NNS cord-023095-4dannjjm 5492 9 for for IN cord-023095-4dannjjm 5492 10 treatment treatment NN cord-023095-4dannjjm 5492 11 of of IN cord-023095-4dannjjm 5492 12 E. E. NNP cord-023095-4dannjjm 5492 13 coli coli VBZ cord-023095-4dannjjm 5492 14 urinary urinary JJ cord-023095-4dannjjm 5492 15 tract tract JJ cord-023095-4dannjjm 5492 16 infections infection NNS cord-023095-4dannjjm 5492 17 ( ( -LRB- cord-023095-4dannjjm 5492 18 UTIs UTIs NNPS cord-023095-4dannjjm 5492 19 ) ) -RRB- cord-023095-4dannjjm 5492 20 in in IN cord-023095-4dannjjm 5492 21 animals animal NNS cord-023095-4dannjjm 5492 22 and and CC cord-023095-4dannjjm 5492 23 humans human NNS cord-023095-4dannjjm 5492 24 . . . cord-023095-4dannjjm 5493 1 2nd 2nd JJ cord-023095-4dannjjm 5493 2 generation generation NN cord-023095-4dannjjm 5493 3 drugs drug NNS cord-023095-4dannjjm 5493 4 approved approve VBN cord-023095-4dannjjm 5493 5 in in IN cord-023095-4dannjjm 5493 6 animals animal NNS cord-023095-4dannjjm 5493 7 include include VBP cord-023095-4dannjjm 5493 8 enrofloxacin enrofloxacin NNS cord-023095-4dannjjm 5493 9 ( ( -LRB- cord-023095-4dannjjm 5493 10 ENR ENR NNP cord-023095-4dannjjm 5493 11 ) ) -RRB- cord-023095-4dannjjm 5493 12 , , , cord-023095-4dannjjm 5493 13 marbofloxacin marbofloxacin NNP cord-023095-4dannjjm 5493 14 ( ( -LRB- cord-023095-4dannjjm 5493 15 MAR MAR NNP cord-023095-4dannjjm 5493 16 ) ) -RRB- cord-023095-4dannjjm 5493 17 , , , cord-023095-4dannjjm 5493 18 orbifloxacin orbifloxacin NNP cord-023095-4dannjjm 5493 19 ( ( -LRB- cord-023095-4dannjjm 5493 20 ORB orb NN cord-023095-4dannjjm 5493 21 ) ) -RRB- cord-023095-4dannjjm 5493 22 ; ; : cord-023095-4dannjjm 5493 23 human human JJ cord-023095-4dannjjm 5493 24 drugs drug NNS cord-023095-4dannjjm 5493 25 include include VBP cord-023095-4dannjjm 5493 26 ciprofloxacin ciprofloxacin NNS cord-023095-4dannjjm 5493 27 ( ( -LRB- cord-023095-4dannjjm 5493 28 CIP CIP NNP cord-023095-4dannjjm 5493 29 ) ) -RRB- cord-023095-4dannjjm 5493 30 . . . cord-023095-4dannjjm 5494 1 3rd 3rd JJ cord-023095-4dannjjm 5494 2 and and CC cord-023095-4dannjjm 5494 3 4th 4th JJ cord-023095-4dannjjm 5494 4 generation generation NN cord-023095-4dannjjm 5494 5 FQ FQ NNP cord-023095-4dannjjm 5494 6 for for IN cord-023095-4dannjjm 5494 7 humans human NNS cord-023095-4dannjjm 5494 8 include include VBP cord-023095-4dannjjm 5494 9 moxifloxacin moxifloxacin NNS cord-023095-4dannjjm 5494 10 ( ( -LRB- cord-023095-4dannjjm 5494 11 MOX MOX NNP cord-023095-4dannjjm 5494 12 ) ) -RRB- cord-023095-4dannjjm 5494 13 , , , cord-023095-4dannjjm 5494 14 gatifloxacin gatifloxacin NNP cord-023095-4dannjjm 5494 15 ( ( -LRB- cord-023095-4dannjjm 5494 16 GAT GAT NNP cord-023095-4dannjjm 5494 17 ) ) -RRB- cord-023095-4dannjjm 5494 18 and and CC cord-023095-4dannjjm 5494 19 ofloxacin ofloxacin NNS cord-023095-4dannjjm 5494 20 , , , cord-023095-4dannjjm 5494 21 ( ( -LRB- cord-023095-4dannjjm 5494 22 OFL OFL NNP cord-023095-4dannjjm 5494 23 ] ] -RRB- cord-023095-4dannjjm 5494 24 ) ) -RRB- cord-023095-4dannjjm 5494 25 , , , cord-023095-4dannjjm 5494 26 its -PRON- PRP$ cord-023095-4dannjjm 5494 27 Lisoform Lisoform NNP cord-023095-4dannjjm 5494 28 levofloxacin levofloxacin NNS cord-023095-4dannjjm 5494 29 ( ( -LRB- cord-023095-4dannjjm 5494 30 LEV LEV NNP cord-023095-4dannjjm 5494 31 ) ) -RRB- cord-023095-4dannjjm 5494 32 . . . cord-023095-4dannjjm 5495 1 For for IN cord-023095-4dannjjm 5495 2 animals animal NNS cord-023095-4dannjjm 5495 3 , , , cord-023095-4dannjjm 5495 4 pradofloxacin pradofloxacin NNS cord-023095-4dannjjm 5495 5 ( ( -LRB- cord-023095-4dannjjm 5495 6 PRA PRA NNP cord-023095-4dannjjm 5495 7 ) ) -RRB- cord-023095-4dannjjm 5495 8 is be VBZ cord-023095-4dannjjm 5495 9 approved approve VBN cord-023095-4dannjjm 5495 10 for for IN cord-023095-4dannjjm 5495 11 use use NN cord-023095-4dannjjm 5495 12 in in IN cord-023095-4dannjjm 5495 13 Europe Europe NNP cord-023095-4dannjjm 5495 14 . . . cord-023095-4dannjjm 5496 1 The the DT cord-023095-4dannjjm 5496 2 purpose purpose NN cord-023095-4dannjjm 5496 3 of of IN cord-023095-4dannjjm 5496 4 this this DT cord-023095-4dannjjm 5496 5 study study NN cord-023095-4dannjjm 5496 6 was be VBD cord-023095-4dannjjm 5496 7 to to TO cord-023095-4dannjjm 5496 8 assess assess VB cord-023095-4dannjjm 5496 9 the the DT cord-023095-4dannjjm 5496 10 in in FW cord-023095-4dannjjm 5496 11 vitro vitro FW cord-023095-4dannjjm 5496 12 activity activity NN cord-023095-4dannjjm 5496 13 of of IN cord-023095-4dannjjm 5496 14 1st 1st NN cord-023095-4dannjjm 5497 1 ( ( -LRB- cord-023095-4dannjjm 5497 2 Naladixic Naladixic NNP cord-023095-4dannjjm 5497 3 acid acid NN cord-023095-4dannjjm 5497 4 [ [ -LRB- cord-023095-4dannjjm 5497 5 NAL NAL NNP cord-023095-4dannjjm 5497 6 ] ] -RRB- cord-023095-4dannjjm 5497 7 through through IN cord-023095-4dannjjm 5497 8 4th 4th JJ cord-023095-4dannjjm 5497 9 generation generation NN cord-023095-4dannjjm 5497 10 FQs FQs NNP cord-023095-4dannjjm 5497 11 ( ( -LRB- cord-023095-4dannjjm 5497 12 n n NN cord-023095-4dannjjm 5497 13 5 5 CD cord-023095-4dannjjm 5497 14 11 11 CD cord-023095-4dannjjm 5497 15 ) ) -RRB- cord-023095-4dannjjm 5498 1 toward toward IN cord-023095-4dannjjm 5498 2 dog dog NN cord-023095-4dannjjm 5498 3 or or CC cord-023095-4dannjjm 5498 4 cat cat NN cord-023095-4dannjjm 5499 1 E.coli E.coli NNP cord-023095-4dannjjm 5499 2 uropathogens uropathogens NNP cord-023095-4dannjjm 5499 3 ( ( -LRB- cord-023095-4dannjjm 5499 4 n n NN cord-023095-4dannjjm 5499 5 5 5 CD cord-023095-4dannjjm 5499 6 51 51 CD cord-023095-4dannjjm 5499 7 ) ) -RRB- cord-023095-4dannjjm 5499 8 . . . cord-023095-4dannjjm 5500 1 Isolates isolate NNS cord-023095-4dannjjm 5500 2 were be VBD cord-023095-4dannjjm 5500 3 subjected subject VBN cord-023095-4dannjjm 5500 4 to to IN cord-023095-4dannjjm 5500 5 susceptibility susceptibility NN cord-023095-4dannjjm 5500 6 testing testing NN cord-023095-4dannjjm 5500 7 to to IN cord-023095-4dannjjm 5500 8 6 6 CD cord-023095-4dannjjm 5500 9 drugs drug NNS cord-023095-4dannjjm 5500 10 classes class NNS cord-023095-4dannjjm 5500 11 ( ( -LRB- cord-023095-4dannjjm 5500 12 15 15 CD cord-023095-4dannjjm 5500 13 drugs drug NNS cord-023095-4dannjjm 5500 14 ) ) -RRB- cord-023095-4dannjjm 5500 15 . . . cord-023095-4dannjjm 5501 1 Isolate isolate NN cord-023095-4dannjjm 5501 2 phenotypes phenotype NNS cord-023095-4dannjjm 5501 3 included include VBN cord-023095-4dannjjm 5501 4 no no DT cord-023095-4dannjjm 5501 5 ( ( -LRB- cord-023095-4dannjjm 5501 6 NDR NDR NNP cord-023095-4dannjjm 5501 7 ; ; : cord-023095-4dannjjm 5501 8 n n NN cord-023095-4dannjjm 5501 9 5 5 CD cord-023095-4dannjjm 5501 10 12 12 CD cord-023095-4dannjjm 5501 11 ) ) -RRB- cord-023095-4dannjjm 5501 12 , , , cord-023095-4dannjjm 5501 13 single single JJ cord-023095-4dannjjm 5501 14 ( ( -LRB- cord-023095-4dannjjm 5501 15 SDR SDR NNP cord-023095-4dannjjm 5501 16 ; ; : cord-023095-4dannjjm 5501 17 n n NN cord-023095-4dannjjm 5501 18 5 5 CD cord-023095-4dannjjm 5501 19 15 15 CD cord-023095-4dannjjm 5501 20 ) ) -RRB- cord-023095-4dannjjm 5501 21 or or CC cord-023095-4dannjjm 5501 22 multidrug multidrug NN cord-023095-4dannjjm 5501 23 ( ( -LRB- cord-023095-4dannjjm 5501 24 to to IN cord-023095-4dannjjm 5501 25 more more JJR cord-023095-4dannjjm 5501 26 than than IN cord-023095-4dannjjm 5501 27 2 2 CD cord-023095-4dannjjm 5501 28 drug drug NN cord-023095-4dannjjm 5501 29 classes class NNS cord-023095-4dannjjm 5501 30 ; ; : cord-023095-4dannjjm 5501 31 MDR MDR NNP cord-023095-4dannjjm 5501 32 ; ; : cord-023095-4dannjjm 5501 33 n n NN cord-023095-4dannjjm 5501 34 5 5 CD cord-023095-4dannjjm 5501 35 24 24 CD cord-023095-4dannjjm 5501 36 ) ) -RRB- cord-023095-4dannjjm 5501 37 resistance resistance NN cord-023095-4dannjjm 5501 38 ( ( -LRB- cord-023095-4dannjjm 5501 39 including include VBG cord-023095-4dannjjm 5501 40 ENR ENR NNP cord-023095-4dannjjm 5501 41 resistant resistant JJ cord-023095-4dannjjm 5501 42 [ [ -LRB- cord-023095-4dannjjm 5501 43 ENR ENR NNP cord-023095-4dannjjm 5501 44 R R NNP cord-023095-4dannjjm 5501 45 -MDR -MDR '' cord-023095-4dannjjm 5501 46 ; ; : cord-023095-4dannjjm 5501 47 n n NN cord-023095-4dannjjm 5501 48 5 5 CD cord-023095-4dannjjm 5501 49 12 12 CD cord-023095-4dannjjm 5501 50 ] ] -RRB- cord-023095-4dannjjm 5501 51 or or CC cord-023095-4dannjjm 5501 52 ENR ENR NNP cord-023095-4dannjjm 5501 53 susceptible susceptible JJ cord-023095-4dannjjm 5501 54 ( ( -LRB- cord-023095-4dannjjm 5501 55 ENR ENR NNP cord-023095-4dannjjm 5501 56 S S NNP cord-023095-4dannjjm 5501 57 -MDR -MDR -RRB- cord-023095-4dannjjm 5501 58 , , , cord-023095-4dannjjm 5501 59 n n NN cord-023095-4dannjjm 5501 60 5 5 CD cord-023095-4dannjjm 5501 61 12 12 CD cord-023095-4dannjjm 5501 62 ) ) -RRB- cord-023095-4dannjjm 5501 63 . . . cord-023095-4dannjjm 5502 1 The the DT cord-023095-4dannjjm 5502 2 minimum minimum JJ cord-023095-4dannjjm 5502 3 inhibition inhibition NN cord-023095-4dannjjm 5502 4 concentrations concentration NNS cord-023095-4dannjjm 5502 5 ( ( -LRB- cord-023095-4dannjjm 5502 6 MICs mic NNS cord-023095-4dannjjm 5502 7 ) ) -RRB- cord-023095-4dannjjm 5502 8 were be VBD cord-023095-4dannjjm 5502 9 determined determine VBN cord-023095-4dannjjm 5502 10 for for IN cord-023095-4dannjjm 5502 11 each each DT cord-023095-4dannjjm 5502 12 isolates isolate NNS cord-023095-4dannjjm 5502 13 using use VBG cord-023095-4dannjjm 5502 14 broth broth NN cord-023095-4dannjjm 5502 15 microdilution microdilution NNP cord-023095-4dannjjm 5502 16 ( ( -LRB- cord-023095-4dannjjm 5502 17 E. E. NNP cord-023095-4dannjjm 5502 18 coli coli VBZ cord-023095-4dannjjm 5502 19 ATCC ATCC NNP cord-023095-4dannjjm 5502 20 s s POS cord-023095-4dannjjm 5502 21 25922 25922 CD cord-023095-4dannjjm 5502 22 served serve VBD cord-023095-4dannjjm 5502 23 as as IN cord-023095-4dannjjm 5502 24 a a DT cord-023095-4dannjjm 5502 25 negative negative JJ cord-023095-4dannjjm 5502 26 control control NN cord-023095-4dannjjm 5502 27 ) ) -RRB- cord-023095-4dannjjm 5502 28 . . . cord-023095-4dannjjm 5503 1 MIC mic NN cord-023095-4dannjjm 5503 2 statistics statistic NNS cord-023095-4dannjjm 5503 3 were be VBD cord-023095-4dannjjm 5503 4 generated generate VBN cord-023095-4dannjjm 5503 5 for for IN cord-023095-4dannjjm 5503 6 each each DT cord-023095-4dannjjm 5503 7 drug drug NN cord-023095-4dannjjm 5503 8 among among IN cord-023095-4dannjjm 5503 9 phenotypes phenotype NNS cord-023095-4dannjjm 5503 10 . . . cord-023095-4dannjjm 5504 1 The the DT cord-023095-4dannjjm 5504 2 overall overall JJ cord-023095-4dannjjm 5504 3 potency potency NN cord-023095-4dannjjm 5504 4 ( ( -LRB- cord-023095-4dannjjm 5504 5 MIC MIC NNP cord-023095-4dannjjm 5504 6 90 90 CD cord-023095-4dannjjm 5504 7 ) ) -RRB- cord-023095-4dannjjm 5504 8 for for IN cord-023095-4dannjjm 5504 9 all all DT cord-023095-4dannjjm 5504 10 ENR ENR NNP cord-023095-4dannjjm 5504 11 susceptible susceptible JJ cord-023095-4dannjjm 5504 12 isolates isolate NNS cord-023095-4dannjjm 5504 13 ( ( -LRB- cord-023095-4dannjjm 5504 14 NDR NDR NNP cord-023095-4dannjjm 5504 15 , , , cord-023095-4dannjjm 5504 16 SDR SDR NNP cord-023095-4dannjjm 5504 17 and and CC cord-023095-4dannjjm 5504 18 ENR ENR NNP cord-023095-4dannjjm 5504 19 S S NNP cord-023095-4dannjjm 5504 20 -MDR -MDR -RRB- cord-023095-4dannjjm 5504 21 ) ) -RRB- cord-023095-4dannjjm 5504 22 was be VBD cord-023095-4dannjjm 5504 23 GAT GAT NNP cord-023095-4dannjjm 5504 24 4 4 CD cord-023095-4dannjjm 5504 25 PRA PRA NNP cord-023095-4dannjjm 5504 26 , , , cord-023095-4dannjjm 5504 27 MOX MOX NNP cord-023095-4dannjjm 5504 28 , , , cord-023095-4dannjjm 5504 29 MAR MAR NNP cord-023095-4dannjjm 5504 30 , , , cord-023095-4dannjjm 5504 31 LEV LEV NNP cord-023095-4dannjjm 5504 32 , , , cord-023095-4dannjjm 5504 33 CIP CIP NNP cord-023095-4dannjjm 5504 34 4 4 CD cord-023095-4dannjjm 5504 35 SAR SAR NNP cord-023095-4dannjjm 5504 36 , , , cord-023095-4dannjjm 5504 37 ORB orb NN cord-023095-4dannjjm 5504 38 , , , cord-023095-4dannjjm 5504 39 OFL OFL NNP cord-023095-4dannjjm 5504 40 4 4 CD cord-023095-4dannjjm 5504 41 ENR ENR NNP cord-023095-4dannjjm 5504 42 4 4 CD cord-023095-4dannjjm 5504 43 NAL NAL NNP cord-023095-4dannjjm 5504 44 . . . cord-023095-4dannjjm 5505 1 Each each DT cord-023095-4dannjjm 5505 2 E. E. NNP cord-023095-4dannjjm 5505 3 coli coli NNS cord-023095-4dannjjm 5505 4 isolate isolate VBP cord-023095-4dannjjm 5505 5 expressing express VBG cord-023095-4dannjjm 5505 6 NDR NDR NNP cord-023095-4dannjjm 5505 7 or or CC cord-023095-4dannjjm 5505 8 SDR SDR NNP cord-023095-4dannjjm 5505 9 was be VBD cord-023095-4dannjjm 5505 10 susceptible susceptible JJ cord-023095-4dannjjm 5505 11 to to IN cord-023095-4dannjjm 5505 12 all all DT cord-023095-4dannjjm 5505 13 FQ FQ NNP cord-023095-4dannjjm 5505 14 . . . cord-023095-4dannjjm 5506 1 However however RB cord-023095-4dannjjm 5506 2 , , , cord-023095-4dannjjm 5506 3 isolates isolate NNS cord-023095-4dannjjm 5506 4 expressing express VBG cord-023095-4dannjjm 5506 5 resistance resistance NN cord-023095-4dannjjm 5506 6 to to IN cord-023095-4dannjjm 5506 7 1st 1st JJ cord-023095-4dannjjm 5506 8 or or CC cord-023095-4dannjjm 5506 9 2nd 2nd JJ cord-023095-4dannjjm 5506 10 generation generation NN cord-023095-4dannjjm 5506 11 FQ FQ NNP cord-023095-4dannjjm 5506 12 were be VBD cord-023095-4dannjjm 5506 13 also also RB cord-023095-4dannjjm 5506 14 resistance resistance NN cord-023095-4dannjjm 5506 15 to to IN cord-023095-4dannjjm 5506 16 later later JJ cord-023095-4dannjjm 5506 17 generation generation NN cord-023095-4dannjjm 5506 18 drugs drug NNS cord-023095-4dannjjm 5506 19 . . . cord-023095-4dannjjm 5507 1 Glucocorticoids Glucocorticoids NNP cord-023095-4dannjjm 5507 2 ( ( -LRB- cord-023095-4dannjjm 5507 3 GC GC NNP cord-023095-4dannjjm 5507 4 ) ) -RRB- cord-023095-4dannjjm 5507 5 are be VBP cord-023095-4dannjjm 5507 6 standard standard JJ cord-023095-4dannjjm 5507 7 therapy therapy NN cord-023095-4dannjjm 5507 8 for for IN cord-023095-4dannjjm 5507 9 allergic allergic JJ cord-023095-4dannjjm 5507 10 asthma asthma NN cord-023095-4dannjjm 5507 11 but but CC cord-023095-4dannjjm 5507 12 do do VBP cord-023095-4dannjjm 5507 13 not not RB cord-023095-4dannjjm 5507 14 reverse reverse VB cord-023095-4dannjjm 5507 15 the the DT cord-023095-4dannjjm 5507 16 underlying underlying JJ cord-023095-4dannjjm 5507 17 type type NN cord-023095-4dannjjm 5507 18 I -PRON- PRP cord-023095-4dannjjm 5507 19 hypersensitivity hypersensitivity NN cord-023095-4dannjjm 5507 20 . . . cord-023095-4dannjjm 5508 1 Allergenspecific Allergenspecific NNP cord-023095-4dannjjm 5508 2 immunotherapy immunotherapy NN cord-023095-4dannjjm 5508 3 ( ( -LRB- cord-023095-4dannjjm 5508 4 ASIT ASIT NNP cord-023095-4dannjjm 5508 5 ) ) -RRB- cord-023095-4dannjjm 5508 6 , , , cord-023095-4dannjjm 5508 7 a a DT cord-023095-4dannjjm 5508 8 process process NN cord-023095-4dannjjm 5508 9 of of IN cord-023095-4dannjjm 5508 10 ' ' '' cord-023095-4dannjjm 5508 11 ' ' `` cord-023095-4dannjjm 5508 12 desensitization desensitization NN cord-023095-4dannjjm 5508 13 ' ' '' cord-023095-4dannjjm 5508 14 ' ' '' cord-023095-4dannjjm 5508 15 , , , cord-023095-4dannjjm 5508 16 is be VBZ cord-023095-4dannjjm 5508 17 potentially potentially RB cord-023095-4dannjjm 5508 18 curative curative JJ cord-023095-4dannjjm 5508 19 but but CC cord-023095-4dannjjm 5508 20 requires require VBZ cord-023095-4dannjjm 5508 21 identification identification NN cord-023095-4dannjjm 5508 22 of of IN cord-023095-4dannjjm 5508 23 offending offend VBG cord-023095-4dannjjm 5508 24 allergens allergen NNS cord-023095-4dannjjm 5508 25 . . . cord-023095-4dannjjm 5509 1 The the DT cord-023095-4dannjjm 5509 2 purpose purpose NN cord-023095-4dannjjm 5509 3 of of IN cord-023095-4dannjjm 5509 4 this this DT cord-023095-4dannjjm 5509 5 study study NN cord-023095-4dannjjm 5509 6 was be VBD cord-023095-4dannjjm 5509 7 to to TO cord-023095-4dannjjm 5509 8 determine determine VB cord-023095-4dannjjm 5509 9 if if IN cord-023095-4dannjjm 5509 10 oral oral JJ cord-023095-4dannjjm 5509 11 or or CC cord-023095-4dannjjm 5509 12 inhaled inhale VBN cord-023095-4dannjjm 5509 13 GC GC NNP cord-023095-4dannjjm 5509 14 administered administer VBN cord-023095-4dannjjm 5509 15 at at IN cord-023095-4dannjjm 5509 16 routinely routinely RB cord-023095-4dannjjm 5509 17 used use VBN cord-023095-4dannjjm 5509 18 dosages dosage NNS cord-023095-4dannjjm 5509 19 would would MD cord-023095-4dannjjm 5509 20 interfere interfere VB cord-023095-4dannjjm 5509 21 with with IN cord-023095-4dannjjm 5509 22 allergen allergen NN cord-023095-4dannjjm 5509 23 identification identification NN cord-023095-4dannjjm 5509 24 . . . cord-023095-4dannjjm 5510 1 We -PRON- PRP cord-023095-4dannjjm 5510 2 hypothesized hypothesize VBD cord-023095-4dannjjm 5510 3 that that IN cord-023095-4dannjjm 5510 4 oral oral JJ cord-023095-4dannjjm 5510 5 but but CC cord-023095-4dannjjm 5510 6 not not RB cord-023095-4dannjjm 5510 7 inhaled inhale VBN cord-023095-4dannjjm 5510 8 GC GC NNP cord-023095-4dannjjm 5510 9 would would MD cord-023095-4dannjjm 5510 10 interfere interfere VB cord-023095-4dannjjm 5510 11 with with IN cord-023095-4dannjjm 5510 12 accurate accurate JJ cord-023095-4dannjjm 5510 13 identification identification NN cord-023095-4dannjjm 5510 14 of of IN cord-023095-4dannjjm 5510 15 allergen allergen NN cord-023095-4dannjjm 5510 16 - - HYPH cord-023095-4dannjjm 5510 17 specific specific JJ cord-023095-4dannjjm 5510 18 IgE ige NN cord-023095-4dannjjm 5510 19 using use VBG cord-023095-4dannjjm 5510 20 skin skin NN cord-023095-4dannjjm 5510 21 and and CC cord-023095-4dannjjm 5510 22 serum serum NN cord-023095-4dannjjm 5510 23 testing testing NN cord-023095-4dannjjm 5510 24 in in IN cord-023095-4dannjjm 5510 25 experimentally experimentally RB cord-023095-4dannjjm 5510 26 asthmatic asthmatic JJ cord-023095-4dannjjm 5510 27 cats cat NNS cord-023095-4dannjjm 5510 28 . . . cord-023095-4dannjjm 5511 1 Asthma asthma NN cord-023095-4dannjjm 5511 2 was be VBD cord-023095-4dannjjm 5511 3 induced induce VBN cord-023095-4dannjjm 5511 4 in in IN cord-023095-4dannjjm 5511 5 eighteen eighteen CD cord-023095-4dannjjm 5511 6 cats cat NNS cord-023095-4dannjjm 5511 7 using use VBG cord-023095-4dannjjm 5511 8 Bermuda Bermuda NNP cord-023095-4dannjjm 5511 9 grass grass NN cord-023095-4dannjjm 5511 10 allergen allergen NN cord-023095-4dannjjm 5511 11 ( ( -LRB- cord-023095-4dannjjm 5511 12 BGA BGA NNP cord-023095-4dannjjm 5511 13 ) ) -RRB- cord-023095-4dannjjm 5511 14 . . . cord-023095-4dannjjm 5512 1 Cats cat NNS cord-023095-4dannjjm 5512 2 ( ( -LRB- cord-023095-4dannjjm 5512 3 n n NN cord-023095-4dannjjm 5512 4 5 5 CD cord-023095-4dannjjm 5512 5 6 6 CD cord-023095-4dannjjm 5512 6 / / SYM cord-023095-4dannjjm 5512 7 group group NN cord-023095-4dannjjm 5512 8 ) ) -RRB- cord-023095-4dannjjm 5512 9 were be VBD cord-023095-4dannjjm 5512 10 randomized randomize VBN cord-023095-4dannjjm 5512 11 to to TO cord-023095-4dannjjm 5512 12 receive receive VB cord-023095-4dannjjm 5512 13 oral oral JJ cord-023095-4dannjjm 5512 14 GC GC NNP cord-023095-4dannjjm 5512 15 ( ( -LRB- cord-023095-4dannjjm 5512 16 10 10 CD cord-023095-4dannjjm 5512 17 mg mg NNP cord-023095-4dannjjm 5512 18 prednisolone prednisolone NN cord-023095-4dannjjm 5512 19 q q NNP cord-023095-4dannjjm 5512 20 24 24 CD cord-023095-4dannjjm 5512 21 hr hr NN cord-023095-4dannjjm 5512 22 PO PO NNP cord-023095-4dannjjm 5512 23 ) ) -RRB- cord-023095-4dannjjm 5512 24 , , , cord-023095-4dannjjm 5512 25 inhaled inhale VBN cord-023095-4dannjjm 5512 26 GC GC NNP cord-023095-4dannjjm 5512 27 ( ( -LRB- cord-023095-4dannjjm 5512 28 600 600 CD cord-023095-4dannjjm 5512 29 ug ug NNP cord-023095-4dannjjm 5512 30 budesonide budesonide NNP cord-023095-4dannjjm 5512 31 q q NNP cord-023095-4dannjjm 5512 32 24hr 24hr NNP cord-023095-4dannjjm 5512 33 ) ) -RRB- cord-023095-4dannjjm 5512 34 or or CC cord-023095-4dannjjm 5512 35 placebo placebo NN cord-023095-4dannjjm 5512 36 ( ( -LRB- cord-023095-4dannjjm 5512 37 gelatin gelatin NN cord-023095-4dannjjm 5512 38 capsule capsule NN cord-023095-4dannjjm 5512 39 q q NNP cord-023095-4dannjjm 5512 40 24hr 24hr NNP cord-023095-4dannjjm 5512 41 PO PO NNP cord-023095-4dannjjm 5512 42 ) ) -RRB- cord-023095-4dannjjm 5512 43 for for IN cord-023095-4dannjjm 5512 44 one one CD cord-023095-4dannjjm 5512 45 month month NN cord-023095-4dannjjm 5512 46 . . . cord-023095-4dannjjm 5513 1 Intradermal intradermal JJ cord-023095-4dannjjm 5513 2 skin skin NN cord-023095-4dannjjm 5513 3 testing testing NN cord-023095-4dannjjm 5513 4 ( ( -LRB- cord-023095-4dannjjm 5513 5 IDST IDST NNP cord-023095-4dannjjm 5513 6 ) ) -RRB- cord-023095-4dannjjm 5513 7 and and CC cord-023095-4dannjjm 5513 8 BGA BGA NNP cord-023095-4dannjjm 5513 9 - - HYPH cord-023095-4dannjjm 5513 10 specific specific JJ cord-023095-4dannjjm 5513 11 IgE IgE NNP cord-023095-4dannjjm 5513 12 amounts amount NNS cord-023095-4dannjjm 5513 13 were be VBD cord-023095-4dannjjm 5513 14 measured measure VBN cord-023095-4dannjjm 5513 15 prior prior RB cord-023095-4dannjjm 5513 16 to to IN cord-023095-4dannjjm 5513 17 , , , cord-023095-4dannjjm 5513 18 during during IN cord-023095-4dannjjm 5513 19 ( ( -LRB- cord-023095-4dannjjm 5513 20 weeks week NNS cord-023095-4dannjjm 5513 21 one one CD cord-023095-4dannjjm 5513 22 and and CC cord-023095-4dannjjm 5513 23 four four CD cord-023095-4dannjjm 5513 24 ) ) -RRB- cord-023095-4dannjjm 5513 25 and and CC cord-023095-4dannjjm 5513 26 every every DT cord-023095-4dannjjm 5513 27 two two CD cord-023095-4dannjjm 5513 28 weeks week NNS cord-023095-4dannjjm 5513 29 after after IN cord-023095-4dannjjm 5513 30 treatment treatment NN cord-023095-4dannjjm 5513 31 until until IN cord-023095-4dannjjm 5513 32 both both DT cord-023095-4dannjjm 5513 33 tests test NNS cord-023095-4dannjjm 5513 34 were be VBD cord-023095-4dannjjm 5513 35 positive positive JJ cord-023095-4dannjjm 5513 36 . . . cord-023095-4dannjjm 5514 1 A a DT cord-023095-4dannjjm 5514 2 paired paired JJ cord-023095-4dannjjm 5514 3 T t NN cord-023095-4dannjjm 5514 4 test test NN cord-023095-4dannjjm 5514 5 was be VBD cord-023095-4dannjjm 5514 6 used use VBN cord-023095-4dannjjm 5514 7 to to TO cord-023095-4dannjjm 5514 8 compare compare VB cord-023095-4dannjjm 5514 9 serum serum NN cord-023095-4dannjjm 5514 10 IgE IgE NNP cord-023095-4dannjjm 5514 11 among among IN cord-023095-4dannjjm 5514 12 groups group NNS cord-023095-4dannjjm 5514 13 pre pre VBP cord-023095-4dannjjm 5514 14 - - JJ cord-023095-4dannjjm 5514 15 and and CC cord-023095-4dannjjm 5514 16 post post JJ cord-023095-4dannjjm 5514 17 - - NN cord-023095-4dannjjm 5514 18 treatment treatment JJ cord-023095-4dannjjm 5515 1 ( ( -LRB- cord-023095-4dannjjm 5515 2 P p NN cord-023095-4dannjjm 5515 3 o o NN cord-023095-4dannjjm 5515 4 0.05 0.05 CD cord-023095-4dannjjm 5515 5 significant significant JJ cord-023095-4dannjjm 5515 6 ) ) -RRB- cord-023095-4dannjjm 5515 7 . . . cord-023095-4dannjjm 5516 1 IDST IDST NNP cord-023095-4dannjjm 5516 2 reactivity reactivity NN cord-023095-4dannjjm 5516 3 was be VBD cord-023095-4dannjjm 5516 4 eliminated eliminate VBN cord-023095-4dannjjm 5516 5 in in IN cord-023095-4dannjjm 5516 6 4/6 4/6 CD cord-023095-4dannjjm 5516 7 cats cat NNS cord-023095-4dannjjm 5516 8 on on IN cord-023095-4dannjjm 5516 9 oral oral JJ cord-023095-4dannjjm 5516 10 GC GC NNP cord-023095-4dannjjm 5516 11 , , , cord-023095-4dannjjm 5516 12 3/6 3/6 CD cord-023095-4dannjjm 5516 13 on on IN cord-023095-4dannjjm 5516 14 inhaled inhale VBN cord-023095-4dannjjm 5516 15 GC GC NNP cord-023095-4dannjjm 5516 16 , , , cord-023095-4dannjjm 5516 17 and and CC cord-023095-4dannjjm 5516 18 1/6 1/6 DT cord-023095-4dannjjm 5516 19 placebo placebo NN cord-023095-4dannjjm 5516 20 - - HYPH cord-023095-4dannjjm 5516 21 treated treat VBN cord-023095-4dannjjm 5516 22 cats cat NNS cord-023095-4dannjjm 5516 23 . . . cord-023095-4dannjjm 5517 1 Within within IN cord-023095-4dannjjm 5517 2 two two CD cord-023095-4dannjjm 5517 3 weeks week NNS cord-023095-4dannjjm 5517 4 after after IN cord-023095-4dannjjm 5517 5 stopping stop VBG cord-023095-4dannjjm 5517 6 treatment treatment NN cord-023095-4dannjjm 5517 7 , , , cord-023095-4dannjjm 5517 8 IDST IDST NNP cord-023095-4dannjjm 5517 9 was be VBD cord-023095-4dannjjm 5517 10 again again RB cord-023095-4dannjjm 5517 11 positive positive JJ cord-023095-4dannjjm 5517 12 in in IN cord-023095-4dannjjm 5517 13 all all DT cord-023095-4dannjjm 5517 14 cats cat NNS cord-023095-4dannjjm 5517 15 . . . cord-023095-4dannjjm 5518 1 Contrary contrary JJ cord-023095-4dannjjm 5518 2 to to IN cord-023095-4dannjjm 5518 3 our -PRON- PRP$ cord-023095-4dannjjm 5518 4 hypothesis hypothesis NN cord-023095-4dannjjm 5518 5 , , , cord-023095-4dannjjm 5518 6 serum serum NNP cord-023095-4dannjjm 5518 7 IgE IgE NNP cord-023095-4dannjjm 5518 8 reactivity reactivity NN cord-023095-4dannjjm 5518 9 to to IN cord-023095-4dannjjm 5518 10 BGA BGA NNP cord-023095-4dannjjm 5518 11 was be VBD cord-023095-4dannjjm 5518 12 not not RB cord-023095-4dannjjm 5518 13 significantly significantly RB cord-023095-4dannjjm 5518 14 diminished diminish VBN cord-023095-4dannjjm 5518 15 by by IN cord-023095-4dannjjm 5518 16 any any DT cord-023095-4dannjjm 5518 17 treatment treatment NN cord-023095-4dannjjm 5518 18 . . . cord-023095-4dannjjm 5519 1 In in IN cord-023095-4dannjjm 5519 2 conclusion conclusion NN cord-023095-4dannjjm 5519 3 , , , cord-023095-4dannjjm 5519 4 a a DT cord-023095-4dannjjm 5519 5 two two CD cord-023095-4dannjjm 5519 6 week week NN cord-023095-4dannjjm 5519 7 withdrawal withdrawal NN cord-023095-4dannjjm 5519 8 from from IN cord-023095-4dannjjm 5519 9 GCs GCs NNP cord-023095-4dannjjm 5519 10 is be VBZ cord-023095-4dannjjm 5519 11 adequate adequate JJ cord-023095-4dannjjm 5519 12 for for IN cord-023095-4dannjjm 5519 13 IDST IDST NNP cord-023095-4dannjjm 5519 14 identification identification NN cord-023095-4dannjjm 5519 15 of of IN cord-023095-4dannjjm 5519 16 allergen allergen NN cord-023095-4dannjjm 5519 17 but but CC cord-023095-4dannjjm 5519 18 no no DT cord-023095-4dannjjm 5519 19 withdrawal withdrawal NN cord-023095-4dannjjm 5519 20 is be VBZ cord-023095-4dannjjm 5519 21 required require VBN cord-023095-4dannjjm 5519 22 prior prior RB cord-023095-4dannjjm 5519 23 to to IN cord-023095-4dannjjm 5519 24 serum serum NN cord-023095-4dannjjm 5519 25 IgE IgE NNP cord-023095-4dannjjm 5519 26 testing testing NN cord-023095-4dannjjm 5519 27 to to TO cord-023095-4dannjjm 5519 28 identify identify VB cord-023095-4dannjjm 5519 29 the the DT cord-023095-4dannjjm 5519 30 sensitizing sensitize VBG cord-023095-4dannjjm 5519 31 allergens allergen NNS cord-023095-4dannjjm 5519 32 . . . cord-023095-4dannjjm 5520 1 Previously previously RB cord-023095-4dannjjm 5520 2 In in IN cord-023095-4dannjjm 5520 3 people people NNS cord-023095-4dannjjm 5520 4 , , , cord-023095-4dannjjm 5520 5 increasing increase VBG cord-023095-4dannjjm 5520 6 severity severity NN cord-023095-4dannjjm 5520 7 of of IN cord-023095-4dannjjm 5520 8 asthma asthma NN cord-023095-4dannjjm 5520 9 is be VBZ cord-023095-4dannjjm 5520 10 associated associate VBN cord-023095-4dannjjm 5520 11 with with IN cord-023095-4dannjjm 5520 12 low low JJ cord-023095-4dannjjm 5520 13 serum serum NN cord-023095-4dannjjm 5520 14 concentrations concentration NNS cord-023095-4dannjjm 5520 15 of of IN cord-023095-4dannjjm 5520 16 25-hydroxyvitamin 25-hydroxyvitamin CD cord-023095-4dannjjm 5520 17 D d NN cord-023095-4dannjjm 5520 18 ( ( -LRB- cord-023095-4dannjjm 5520 19 25-OH 25-OH NNP cord-023095-4dannjjm 5520 20 - - HYPH cord-023095-4dannjjm 5520 21 D D NNP cord-023095-4dannjjm 5520 22 ) ) -RRB- cord-023095-4dannjjm 5520 23 . . . cord-023095-4dannjjm 5521 1 25-OH 25-OH NNP cord-023095-4dannjjm 5521 2 - - HYPH cord-023095-4dannjjm 5521 3 D D NNP cord-023095-4dannjjm 5521 4 is be VBZ cord-023095-4dannjjm 5521 5 thought think VBN cord-023095-4dannjjm 5521 6 to to TO cord-023095-4dannjjm 5521 7 ameliorate ameliorate VB cord-023095-4dannjjm 5521 8 lower low JJR cord-023095-4dannjjm 5521 9 airway airway NN cord-023095-4dannjjm 5521 10 inflammation inflammation NN cord-023095-4dannjjm 5521 11 primarily primarily RB cord-023095-4dannjjm 5521 12 by by IN cord-023095-4dannjjm 5521 13 decreasing decrease VBG cord-023095-4dannjjm 5521 14 the the DT cord-023095-4dannjjm 5521 15 production production NN cord-023095-4dannjjm 5521 16 of of IN cord-023095-4dannjjm 5521 17 pro pro JJ cord-023095-4dannjjm 5521 18 - - JJ cord-023095-4dannjjm 5521 19 inflammatory inflammatory JJ cord-023095-4dannjjm 5521 20 mediators mediator NNS cord-023095-4dannjjm 5521 21 , , , cord-023095-4dannjjm 5521 22 and and CC cord-023095-4dannjjm 5521 23 by by IN cord-023095-4dannjjm 5521 24 increasing increase VBG cord-023095-4dannjjm 5521 25 the the DT cord-023095-4dannjjm 5521 26 production production NN cord-023095-4dannjjm 5521 27 of of IN cord-023095-4dannjjm 5521 28 the the DT cord-023095-4dannjjm 5521 29 anti anti JJ cord-023095-4dannjjm 5521 30 - - JJ cord-023095-4dannjjm 5521 31 inflammatory inflammatory JJ cord-023095-4dannjjm 5521 32 cytokine cytokine NN cord-023095-4dannjjm 5521 33 IL-10 IL-10 NNP cord-023095-4dannjjm 5521 34 . . . cord-023095-4dannjjm 5522 1 In in IN cord-023095-4dannjjm 5522 2 people people NNS cord-023095-4dannjjm 5522 3 , , , cord-023095-4dannjjm 5522 4 serum serum NN cord-023095-4dannjjm 5522 5 25-OH 25-oh CD cord-023095-4dannjjm 5522 6 - - HYPH cord-023095-4dannjjm 5522 7 D d NN cord-023095-4dannjjm 5522 8 concentration concentration NN cord-023095-4dannjjm 5522 9 is be VBZ cord-023095-4dannjjm 5522 10 associated associate VBN cord-023095-4dannjjm 5522 11 with with IN cord-023095-4dannjjm 5522 12 sunlight sunlight NN cord-023095-4dannjjm 5522 13 exposure exposure NN cord-023095-4dannjjm 5522 14 as as RB cord-023095-4dannjjm 5522 15 well well RB cord-023095-4dannjjm 5522 16 as as IN cord-023095-4dannjjm 5522 17 dietary dietary JJ cord-023095-4dannjjm 5522 18 intake intake NN cord-023095-4dannjjm 5522 19 . . . cord-023095-4dannjjm 5523 1 Cats cat NNS cord-023095-4dannjjm 5523 2 do do VBP cord-023095-4dannjjm 5523 3 not not RB cord-023095-4dannjjm 5523 4 rely rely VB cord-023095-4dannjjm 5523 5 on on IN cord-023095-4dannjjm 5523 6 sunlight sunlight NN cord-023095-4dannjjm 5523 7 for for IN cord-023095-4dannjjm 5523 8 vitamin vitamin NN cord-023095-4dannjjm 5523 9 D d NN cord-023095-4dannjjm 5523 10 synthesis synthesis NN cord-023095-4dannjjm 5523 11 ; ; : cord-023095-4dannjjm 5523 12 all all DT cord-023095-4dannjjm 5523 13 vitamin vitamin NN cord-023095-4dannjjm 5523 14 D d NN cord-023095-4dannjjm 5523 15 comes come VBZ cord-023095-4dannjjm 5523 16 from from IN cord-023095-4dannjjm 5523 17 dietary dietary JJ cord-023095-4dannjjm 5523 18 intake intake NN cord-023095-4dannjjm 5523 19 . . . cord-023095-4dannjjm 5524 1 Cats cat NNS cord-023095-4dannjjm 5524 2 have have VBP cord-023095-4dannjjm 5524 3 a a DT cord-023095-4dannjjm 5524 4 naturally naturally RB cord-023095-4dannjjm 5524 5 occurring occur VBG cord-023095-4dannjjm 5524 6 lower low JJR cord-023095-4dannjjm 5524 7 airway airway NN cord-023095-4dannjjm 5524 8 disease disease NN cord-023095-4dannjjm 5524 9 syndrome syndrome NN cord-023095-4dannjjm 5524 10 ( ( -LRB- cord-023095-4dannjjm 5524 11 LAD LAD NNP cord-023095-4dannjjm 5524 12 ) ) -RRB- cord-023095-4dannjjm 5524 13 that that WDT cord-023095-4dannjjm 5524 14 shares share VBZ cord-023095-4dannjjm 5524 15 many many JJ cord-023095-4dannjjm 5524 16 features feature NNS cord-023095-4dannjjm 5524 17 with with IN cord-023095-4dannjjm 5524 18 human human JJ cord-023095-4dannjjm 5524 19 asthma asthma NN cord-023095-4dannjjm 5524 20 . . . cord-023095-4dannjjm 5525 1 The the DT cord-023095-4dannjjm 5525 2 goal goal NN cord-023095-4dannjjm 5525 3 of of IN cord-023095-4dannjjm 5525 4 this this DT cord-023095-4dannjjm 5525 5 study study NN cord-023095-4dannjjm 5525 6 was be VBD cord-023095-4dannjjm 5525 7 to to TO cord-023095-4dannjjm 5525 8 evaluate evaluate VB cord-023095-4dannjjm 5525 9 serum serum NN cord-023095-4dannjjm 5525 10 25-OH 25-oh CD cord-023095-4dannjjm 5525 11 - - HYPH cord-023095-4dannjjm 5525 12 D d NN cord-023095-4dannjjm 5525 13 concentrations concentration NNS cord-023095-4dannjjm 5525 14 in in IN cord-023095-4dannjjm 5525 15 cats cat NNS cord-023095-4dannjjm 5525 16 with with IN cord-023095-4dannjjm 5525 17 LAD lad NN cord-023095-4dannjjm 5525 18 . . . cord-023095-4dannjjm 5526 1 Cats cat NNS cord-023095-4dannjjm 5526 2 with with IN cord-023095-4dannjjm 5526 3 naturally naturally RB cord-023095-4dannjjm 5526 4 developing develop VBG cord-023095-4dannjjm 5526 5 LAD LAD NNP cord-023095-4dannjjm 5526 6 were be VBD cord-023095-4dannjjm 5526 7 enrolled enrol VBN cord-023095-4dannjjm 5526 8 . . . cord-023095-4dannjjm 5527 1 Criteria criterion NNS cord-023095-4dannjjm 5527 2 for for IN cord-023095-4dannjjm 5527 3 a a DT cord-023095-4dannjjm 5527 4 diagnosis diagnosis NN cord-023095-4dannjjm 5527 5 of of IN cord-023095-4dannjjm 5527 6 LAD LAD NNP cord-023095-4dannjjm 5527 7 included include VBD cord-023095-4dannjjm 5527 8 a a DT cord-023095-4dannjjm 5527 9 history history NN cord-023095-4dannjjm 5527 10 of of IN cord-023095-4dannjjm 5527 11 cough cough NN cord-023095-4dannjjm 5527 12 , , , cord-023095-4dannjjm 5527 13 wheeze wheeze NN cord-023095-4dannjjm 5527 14 or or CC cord-023095-4dannjjm 5527 15 respiratory respiratory JJ cord-023095-4dannjjm 5527 16 distress distress NN cord-023095-4dannjjm 5527 17 , , , cord-023095-4dannjjm 5527 18 radiographic radiographic JJ cord-023095-4dannjjm 5527 19 evidence evidence NN cord-023095-4dannjjm 5527 20 of of IN cord-023095-4dannjjm 5527 21 a a DT cord-023095-4dannjjm 5527 22 bronchial bronchial JJ cord-023095-4dannjjm 5527 23 pattern pattern NN cord-023095-4dannjjm 5527 24 and and CC cord-023095-4dannjjm 5527 25 hyperinflation hyperinflation NN cord-023095-4dannjjm 5527 26 , , , cord-023095-4dannjjm 5527 27 negative negative JJ cord-023095-4dannjjm 5527 28 heartworm heartworm NN cord-023095-4dannjjm 5527 29 antigen antigen NN cord-023095-4dannjjm 5527 30 and and CC cord-023095-4dannjjm 5527 31 antibody antibody NN cord-023095-4dannjjm 5527 32 test test NN cord-023095-4dannjjm 5527 33 , , , cord-023095-4dannjjm 5527 34 and and CC cord-023095-4dannjjm 5527 35 a a DT cord-023095-4dannjjm 5527 36 resolution resolution NN cord-023095-4dannjjm 5527 37 of of IN cord-023095-4dannjjm 5527 38 clinical clinical JJ cord-023095-4dannjjm 5527 39 signs sign NNS cord-023095-4dannjjm 5527 40 in in IN cord-023095-4dannjjm 5527 41 response response NN cord-023095-4dannjjm 5527 42 to to IN cord-023095-4dannjjm 5527 43 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 5527 44 . . . cord-023095-4dannjjm 5528 1 Dietary dietary JJ cord-023095-4dannjjm 5528 2 history history NN cord-023095-4dannjjm 5528 3 was be VBD cord-023095-4dannjjm 5528 4 obtained obtain VBN cord-023095-4dannjjm 5528 5 . . . cord-023095-4dannjjm 5529 1 25-OH 25-oh CD cord-023095-4dannjjm 5529 2 - - HYPH cord-023095-4dannjjm 5529 3 D d NN cord-023095-4dannjjm 5529 4 concentrations concentration NNS cord-023095-4dannjjm 5529 5 were be VBD cord-023095-4dannjjm 5529 6 determined determine VBN cord-023095-4dannjjm 5529 7 on on IN cord-023095-4dannjjm 5529 8 serum serum NN cord-023095-4dannjjm 5529 9 samples sample NNS cord-023095-4dannjjm 5529 10 by by IN cord-023095-4dannjjm 5529 11 a a DT cord-023095-4dannjjm 5529 12 commercial commercial JJ cord-023095-4dannjjm 5529 13 laboratory laboratory NN cord-023095-4dannjjm 5529 14 . . . cord-023095-4dannjjm 5530 1 Twelve twelve CD cord-023095-4dannjjm 5530 2 cats cat NNS cord-023095-4dannjjm 5530 3 with with IN cord-023095-4dannjjm 5530 4 LAD LAD NNP cord-023095-4dannjjm 5530 5 were be VBD cord-023095-4dannjjm 5530 6 enrolled enrol VBN cord-023095-4dannjjm 5530 7 . . . cord-023095-4dannjjm 5531 1 All all DT cord-023095-4dannjjm 5531 2 cats cat NNS cord-023095-4dannjjm 5531 3 ate eat VBD cord-023095-4dannjjm 5531 4 commercial commercial JJ cord-023095-4dannjjm 5531 5 cat cat NN cord-023095-4dannjjm 5531 6 food food NN cord-023095-4dannjjm 5531 7 . . . cord-023095-4dannjjm 5532 1 The the DT cord-023095-4dannjjm 5532 2 median median JJ cord-023095-4dannjjm 5532 3 25-OH 25-oh CD cord-023095-4dannjjm 5532 4 - - HYPH cord-023095-4dannjjm 5532 5 D d NN cord-023095-4dannjjm 5532 6 concentration concentration NN cord-023095-4dannjjm 5532 7 was be VBD cord-023095-4dannjjm 5532 8 112 112 CD cord-023095-4dannjjm 5532 9 nmol nmol JJ cord-023095-4dannjjm 5532 10 / / SYM cord-023095-4dannjjm 5532 11 l l NN cord-023095-4dannjjm 5532 12 with with IN cord-023095-4dannjjm 5532 13 a a DT cord-023095-4dannjjm 5532 14 range range NN cord-023095-4dannjjm 5532 15 of of IN cord-023095-4dannjjm 5532 16 65 65 CD cord-023095-4dannjjm 5532 17 - - SYM cord-023095-4dannjjm 5532 18 176 176 CD cord-023095-4dannjjm 5532 19 nmol nmol NNP cord-023095-4dannjjm 5532 20 / / SYM cord-023095-4dannjjm 5532 21 l l NN cord-023095-4dannjjm 5532 22 which which WDT cord-023095-4dannjjm 5532 23 is be VBZ cord-023095-4dannjjm 5532 24 within within IN cord-023095-4dannjjm 5532 25 the the DT cord-023095-4dannjjm 5532 26 reported report VBN cord-023095-4dannjjm 5532 27 reference reference NN cord-023095-4dannjjm 5532 28 range range NN cord-023095-4dannjjm 5532 29 of of IN cord-023095-4dannjjm 5532 30 65 65 CD cord-023095-4dannjjm 5532 31 - - SYM cord-023095-4dannjjm 5532 32 170 170 CD cord-023095-4dannjjm 5532 33 nmol nmol JJ cord-023095-4dannjjm 5532 34 / / SYM cord-023095-4dannjjm 5532 35 l l NN cord-023095-4dannjjm 5532 36 . . . cord-023095-4dannjjm 5533 1 In in IN cord-023095-4dannjjm 5533 2 contrast contrast NN cord-023095-4dannjjm 5533 3 to to IN cord-023095-4dannjjm 5533 4 human human JJ cord-023095-4dannjjm 5533 5 asthma asthma NN cord-023095-4dannjjm 5533 6 , , , cord-023095-4dannjjm 5533 7 lower low JJR cord-023095-4dannjjm 5533 8 airway airway NN cord-023095-4dannjjm 5533 9 disease disease NN cord-023095-4dannjjm 5533 10 in in IN cord-023095-4dannjjm 5533 11 cats cat NNS cord-023095-4dannjjm 5533 12 is be VBZ cord-023095-4dannjjm 5533 13 not not RB cord-023095-4dannjjm 5533 14 associated associate VBN cord-023095-4dannjjm 5533 15 with with IN cord-023095-4dannjjm 5533 16 low low JJ cord-023095-4dannjjm 5533 17 serum serum NN cord-023095-4dannjjm 5533 18 concentrations concentration NNS cord-023095-4dannjjm 5533 19 of of IN cord-023095-4dannjjm 5533 20 25-OH 25-oh CD cord-023095-4dannjjm 5533 21 - - HYPH cord-023095-4dannjjm 5533 22 D. D. NNP cord-023095-4dannjjm 5533 23 Interstitial interstitial JJ cord-023095-4dannjjm 5533 24 lung lung NN cord-023095-4dannjjm 5533 25 diseases disease NNS cord-023095-4dannjjm 5533 26 ( ( -LRB- cord-023095-4dannjjm 5533 27 ILD ILD NNP cord-023095-4dannjjm 5533 28 ) ) -RRB- cord-023095-4dannjjm 5533 29 are be VBP cord-023095-4dannjjm 5533 30 uncommon uncommon JJ cord-023095-4dannjjm 5533 31 in in IN cord-023095-4dannjjm 5533 32 dogs dog NNS cord-023095-4dannjjm 5533 33 , , , cord-023095-4dannjjm 5533 34 with with IN cord-023095-4dannjjm 5533 35 the the DT cord-023095-4dannjjm 5533 36 most most RBS cord-023095-4dannjjm 5533 37 commonly commonly RB cord-023095-4dannjjm 5533 38 recognized recognize VBN cord-023095-4dannjjm 5533 39 ILD ILD NNP cord-023095-4dannjjm 5533 40 idiopathic idiopathic JJ cord-023095-4dannjjm 5533 41 pulmonary pulmonary JJ cord-023095-4dannjjm 5533 42 fibrosis fibrosis NN cord-023095-4dannjjm 5533 43 ( ( -LRB- cord-023095-4dannjjm 5533 44 ' ' '' cord-023095-4dannjjm 5533 45 ' ' '' cord-023095-4dannjjm 5533 46 Westie Westie NNP cord-023095-4dannjjm 5533 47 fibrosis fibrosis NN cord-023095-4dannjjm 5533 48 ' ' '' cord-023095-4dannjjm 5533 49 ' ' '' cord-023095-4dannjjm 5533 50 ) ) -RRB- cord-023095-4dannjjm 5533 51 . . . cord-023095-4dannjjm 5534 1 In in IN cord-023095-4dannjjm 5534 2 human human JJ cord-023095-4dannjjm 5534 3 medicine medicine NN cord-023095-4dannjjm 5534 4 , , , cord-023095-4dannjjm 5534 5 ILD ILD NNP cord-023095-4dannjjm 5534 6 represent represent VBP cord-023095-4dannjjm 5534 7 a a DT cord-023095-4dannjjm 5534 8 large large JJ cord-023095-4dannjjm 5534 9 umbrella umbrella NN cord-023095-4dannjjm 5534 10 of of IN cord-023095-4dannjjm 5534 11 pulmonary pulmonary JJ cord-023095-4dannjjm 5534 12 diseases disease NNS cord-023095-4dannjjm 5534 13 , , , cord-023095-4dannjjm 5534 14 with with IN cord-023095-4dannjjm 5534 15 IPF IPF NNP cord-023095-4dannjjm 5534 16 only only RB cord-023095-4dannjjm 5534 17 a a DT cord-023095-4dannjjm 5534 18 subset subset NN cord-023095-4dannjjm 5534 19 . . . cord-023095-4dannjjm 5535 1 Other other JJ cord-023095-4dannjjm 5535 2 , , , cord-023095-4dannjjm 5535 3 more more RBR cord-023095-4dannjjm 5535 4 treatable treatable JJ cord-023095-4dannjjm 5535 5 , , , cord-023095-4dannjjm 5535 6 ILDs ild NNS cord-023095-4dannjjm 5535 7 are be VBP cord-023095-4dannjjm 5535 8 also also RB cord-023095-4dannjjm 5535 9 identified identify VBN cord-023095-4dannjjm 5535 10 , , , cord-023095-4dannjjm 5535 11 and and CC cord-023095-4dannjjm 5535 12 may may MD cord-023095-4dannjjm 5535 13 respond respond VB cord-023095-4dannjjm 5535 14 to to IN cord-023095-4dannjjm 5535 15 either either CC cord-023095-4dannjjm 5535 16 the the DT cord-023095-4dannjjm 5535 17 removal removal NN cord-023095-4dannjjm 5535 18 of of IN cord-023095-4dannjjm 5535 19 a a DT cord-023095-4dannjjm 5535 20 stimulus stimulus NN cord-023095-4dannjjm 5535 21 ( ( -LRB- cord-023095-4dannjjm 5535 22 hypersensitivity hypersensitivity NN cord-023095-4dannjjm 5535 23 ) ) -RRB- cord-023095-4dannjjm 5535 24 or or CC cord-023095-4dannjjm 5535 25 steroid steroid NN cord-023095-4dannjjm 5535 26 therapy therapy NN cord-023095-4dannjjm 5535 27 . . . cord-023095-4dannjjm 5536 1 The the DT cord-023095-4dannjjm 5536 2 goal goal NN cord-023095-4dannjjm 5536 3 of of IN cord-023095-4dannjjm 5536 4 this this DT cord-023095-4dannjjm 5536 5 report report NN cord-023095-4dannjjm 5536 6 is be VBZ cord-023095-4dannjjm 5536 7 to to TO cord-023095-4dannjjm 5536 8 describe describe VB cord-023095-4dannjjm 5536 9 the the DT cord-023095-4dannjjm 5536 10 clinical clinical JJ cord-023095-4dannjjm 5536 11 course course NN cord-023095-4dannjjm 5536 12 , , , cord-023095-4dannjjm 5536 13 including include VBG cord-023095-4dannjjm 5536 14 outcome outcome NN cord-023095-4dannjjm 5536 15 , , , cord-023095-4dannjjm 5536 16 computed compute VBN cord-023095-4dannjjm 5536 17 tomography tomography NN cord-023095-4dannjjm 5536 18 and and CC cord-023095-4dannjjm 5536 19 histopathology histopathology NN cord-023095-4dannjjm 5536 20 of of IN cord-023095-4dannjjm 5536 21 dogs dog NNS cord-023095-4dannjjm 5536 22 affected affect VBN cord-023095-4dannjjm 5536 23 with with IN cord-023095-4dannjjm 5536 24 an an DT cord-023095-4dannjjm 5536 25 ILD ILD NNP cord-023095-4dannjjm 5536 26 . . . cord-023095-4dannjjm 5537 1 The the DT cord-023095-4dannjjm 5537 2 computed compute VBN cord-023095-4dannjjm 5537 3 tomography tomography NN cord-023095-4dannjjm 5537 4 ( ( -LRB- cord-023095-4dannjjm 5537 5 CT CT NNP cord-023095-4dannjjm 5537 6 ) ) -RRB- cord-023095-4dannjjm 5537 7 log log NN cord-023095-4dannjjm 5537 8 was be VBD cord-023095-4dannjjm 5537 9 reviewed review VBN cord-023095-4dannjjm 5537 10 for for IN cord-023095-4dannjjm 5537 11 dogs dog NNS cord-023095-4dannjjm 5537 12 that that WDT cord-023095-4dannjjm 5537 13 underwent undergo VBD cord-023095-4dannjjm 5537 14 thoracic thoracic JJ cord-023095-4dannjjm 5537 15 CT CT NNP cord-023095-4dannjjm 5537 16 scanning scanning NN cord-023095-4dannjjm 5537 17 for for IN cord-023095-4dannjjm 5537 18 evaluation evaluation NN cord-023095-4dannjjm 5537 19 of of IN cord-023095-4dannjjm 5537 20 respiratory respiratory JJ cord-023095-4dannjjm 5537 21 signs sign NNS cord-023095-4dannjjm 5537 22 , , , cord-023095-4dannjjm 5537 23 and and CC cord-023095-4dannjjm 5537 24 had have VBD cord-023095-4dannjjm 5537 25 changes change NNS cord-023095-4dannjjm 5537 26 consistent consistent JJ cord-023095-4dannjjm 5537 27 with with IN cord-023095-4dannjjm 5537 28 ILD ILD NNP cord-023095-4dannjjm 5537 29 as as IN cord-023095-4dannjjm 5537 30 the the DT cord-023095-4dannjjm 5537 31 primary primary JJ cord-023095-4dannjjm 5537 32 abnormality abnormality NN cord-023095-4dannjjm 5537 33 , , , cord-023095-4dannjjm 5537 34 including include VBG cord-023095-4dannjjm 5537 35 the the DT cord-023095-4dannjjm 5537 36 presence presence NN cord-023095-4dannjjm 5537 37 of of IN cord-023095-4dannjjm 5537 38 diffuse diffuse JJ cord-023095-4dannjjm 5537 39 disease disease NN cord-023095-4dannjjm 5537 40 in in IN cord-023095-4dannjjm 5537 41 all all DT cord-023095-4dannjjm 5537 42 lobes lobe NNS cord-023095-4dannjjm 5537 43 , , , cord-023095-4dannjjm 5537 44 and and CC cord-023095-4dannjjm 5537 45 at at IN cord-023095-4dannjjm 5537 46 least least JJS cord-023095-4dannjjm 5537 47 2 2 CD cord-023095-4dannjjm 5537 48 of of IN cord-023095-4dannjjm 5537 49 the the DT cord-023095-4dannjjm 5537 50 following follow VBG cord-023095-4dannjjm 5537 51 : : : cord-023095-4dannjjm 5537 52 reticulation reticulation NN cord-023095-4dannjjm 5537 53 , , , cord-023095-4dannjjm 5537 54 ground ground NN cord-023095-4dannjjm 5537 55 glass glass NN cord-023095-4dannjjm 5537 56 opacity opacity NN cord-023095-4dannjjm 5537 57 , , , cord-023095-4dannjjm 5537 58 consolidation consolidation NN cord-023095-4dannjjm 5537 59 , , , cord-023095-4dannjjm 5537 60 or or CC cord-023095-4dannjjm 5537 61 traction traction NN cord-023095-4dannjjm 5537 62 bronchiectasis bronchiectasis NN cord-023095-4dannjjm 5537 63 . . . cord-023095-4dannjjm 5538 1 Survival survival NN cord-023095-4dannjjm 5538 2 time time NN cord-023095-4dannjjm 5538 3 from from IN cord-023095-4dannjjm 5538 4 CT CT NNP cord-023095-4dannjjm 5538 5 date date NN cord-023095-4dannjjm 5538 6 was be VBD cord-023095-4dannjjm 5538 7 calculated calculate VBN cord-023095-4dannjjm 5538 8 . . . cord-023095-4dannjjm 5539 1 The the DT cord-023095-4dannjjm 5539 2 presence presence NN cord-023095-4dannjjm 5539 3 of of IN cord-023095-4dannjjm 5539 4 moderate moderate JJ cord-023095-4dannjjm 5539 5 pulmonary pulmonary JJ cord-023095-4dannjjm 5539 6 hypertension hypertension NN cord-023095-4dannjjm 5539 7 [ [ -LRB- cord-023095-4dannjjm 5539 8 pHTN pHTN NNP cord-023095-4dannjjm 5539 9 ] ] -RRB- cord-023095-4dannjjm 5539 10 ( ( -LRB- cord-023095-4dannjjm 5539 11 4 4 CD cord-023095-4dannjjm 5539 12 50 50 CD cord-023095-4dannjjm 5539 13 mmHg mmHg NNS cord-023095-4dannjjm 5539 14 ) ) -RRB- cord-023095-4dannjjm 5539 15 as as IN cord-023095-4dannjjm 5539 16 estimated estimate VBN cord-023095-4dannjjm 5539 17 by by IN cord-023095-4dannjjm 5539 18 tricuspid tricuspid NNP cord-023095-4dannjjm 5539 19 regurgitant regurgitant NNP cord-023095-4dannjjm 5539 20 jet jet NN cord-023095-4dannjjm 5539 21 , , , cord-023095-4dannjjm 5539 22 was be VBD cord-023095-4dannjjm 5539 23 also also RB cord-023095-4dannjjm 5539 24 reported report VBN cord-023095-4dannjjm 5539 25 and and CC cord-023095-4dannjjm 5539 26 survival survival NN cord-023095-4dannjjm 5539 27 times time NNS cord-023095-4dannjjm 5539 28 were be VBD cord-023095-4dannjjm 5539 29 compared compare VBN cord-023095-4dannjjm 5539 30 with with IN cord-023095-4dannjjm 5539 31 a a DT cord-023095-4dannjjm 5539 32 Mann Mann NNP cord-023095-4dannjjm 5539 33 - - HYPH cord-023095-4dannjjm 5539 34 Whitney Whitney NNP cord-023095-4dannjjm 5539 35 rank rank NN cord-023095-4dannjjm 5539 36 sum sum NN cord-023095-4dannjjm 5539 37 with with IN cord-023095-4dannjjm 5539 38 P p NN cord-023095-4dannjjm 5539 39 o o NN cord-023095-4dannjjm 5539 40 0.05 0.05 CD cord-023095-4dannjjm 5539 41 considered consider VBN cord-023095-4dannjjm 5539 42 significant significant JJ cord-023095-4dannjjm 5539 43 . . . cord-023095-4dannjjm 5540 1 Thirteen thirteen CD cord-023095-4dannjjm 5540 2 dogs dog NNS cord-023095-4dannjjm 5540 3 were be VBD cord-023095-4dannjjm 5540 4 identified identify VBN cord-023095-4dannjjm 5540 5 . . . cord-023095-4dannjjm 5541 1 Terriers Terriers NNPS cord-023095-4dannjjm 5541 2 and and CC cord-023095-4dannjjm 5541 3 Chihuahuas Chihuahuas NNPS cord-023095-4dannjjm 5541 4 were be VBD cord-023095-4dannjjm 5541 5 the the DT cord-023095-4dannjjm 5541 6 most most RBS cord-023095-4dannjjm 5541 7 commonly commonly RB cord-023095-4dannjjm 5541 8 affected affect VBN cord-023095-4dannjjm 5541 9 breeds breed NNS cord-023095-4dannjjm 5541 10 . . . cord-023095-4dannjjm 5542 1 Two two CD cord-023095-4dannjjm 5542 2 dogs dog NNS cord-023095-4dannjjm 5542 3 were be VBD cord-023095-4dannjjm 5542 4 adolescents adolescent NNS cord-023095-4dannjjm 5542 5 , , , cord-023095-4dannjjm 5542 6 the the DT cord-023095-4dannjjm 5542 7 remaining remain VBG cord-023095-4dannjjm 5542 8 dogs dog NNS cord-023095-4dannjjm 5542 9 ranged range VBD cord-023095-4dannjjm 5542 10 from from IN cord-023095-4dannjjm 5542 11 7 7 CD cord-023095-4dannjjm 5542 12 - - SYM cord-023095-4dannjjm 5542 13 16 16 CD cord-023095-4dannjjm 5542 14 years year NNS cord-023095-4dannjjm 5542 15 , , , cord-023095-4dannjjm 5542 16 with with IN cord-023095-4dannjjm 5542 17 a a DT cord-023095-4dannjjm 5542 18 median median NN cord-023095-4dannjjm 5542 19 of of IN cord-023095-4dannjjm 5542 20 11 11 CD cord-023095-4dannjjm 5542 21 years year NNS cord-023095-4dannjjm 5542 22 . . . cord-023095-4dannjjm 5543 1 Histopathology Histopathology NNP cord-023095-4dannjjm 5543 2 results result NNS cord-023095-4dannjjm 5543 3 ( ( -LRB- cord-023095-4dannjjm 5543 4 n n NN cord-023095-4dannjjm 5543 5 5 5 CD cord-023095-4dannjjm 5543 6 5 5 CD cord-023095-4dannjjm 5543 7 ) ) -RRB- cord-023095-4dannjjm 5543 8 , , , cord-023095-4dannjjm 5543 9 including include VBG cord-023095-4dannjjm 5543 10 moderate moderate JJ cord-023095-4dannjjm 5543 11 to to IN cord-023095-4dannjjm 5543 12 severe severe JJ cord-023095-4dannjjm 5543 13 interstitial interstitial JJ cord-023095-4dannjjm 5543 14 fibrosis fibrosis NN cord-023095-4dannjjm 5543 15 ( ( -LRB- cord-023095-4dannjjm 5543 16 3 3 CD cord-023095-4dannjjm 5543 17 ) ) -RRB- cord-023095-4dannjjm 5543 18 alveolar alveolar JJ cord-023095-4dannjjm 5543 19 proteinosis proteinosis NN cord-023095-4dannjjm 5543 20 with with IN cord-023095-4dannjjm 5543 21 fibrosis fibrosis NN cord-023095-4dannjjm 5543 22 ( ( -LRB- cord-023095-4dannjjm 5543 23 1 1 CD cord-023095-4dannjjm 5543 24 ) ) -RRB- cord-023095-4dannjjm 5543 25 , , , cord-023095-4dannjjm 5543 26 and and CC cord-023095-4dannjjm 5543 27 interstitial interstitial JJ cord-023095-4dannjjm 5543 28 eosinophilic eosinophilic JJ cord-023095-4dannjjm 5543 29 pneumonia pneumonia NN cord-023095-4dannjjm 5543 30 ( ( -LRB- cord-023095-4dannjjm 5543 31 1 1 CD cord-023095-4dannjjm 5543 32 ) ) -RRB- cord-023095-4dannjjm 5543 33 . . . cord-023095-4dannjjm 5544 1 One one PRP cord-023095-4dannjjm 5544 2 had have VBD cord-023095-4dannjjm 5544 3 suspected suspect VBN cord-023095-4dannjjm 5544 4 cryptogenic cryptogenic JJ cord-023095-4dannjjm 5544 5 organizing organize VBG cord-023095-4dannjjm 5544 6 pneumonia pneumonia NN cord-023095-4dannjjm 5544 7 and and CC cord-023095-4dannjjm 5544 8 had have VBD cord-023095-4dannjjm 5544 9 a a DT cord-023095-4dannjjm 5544 10 good good JJ cord-023095-4dannjjm 5544 11 response response NN cord-023095-4dannjjm 5544 12 to to IN cord-023095-4dannjjm 5544 13 glucocorticoids glucocorticoid NNS cord-023095-4dannjjm 5544 14 . . . cord-023095-4dannjjm 5545 1 Eight eight CD cord-023095-4dannjjm 5545 2 dogs dog NNS cord-023095-4dannjjm 5545 3 died die VBD cord-023095-4dannjjm 5545 4 of of IN cord-023095-4dannjjm 5545 5 respiratory respiratory JJ cord-023095-4dannjjm 5545 6 failure failure NN cord-023095-4dannjjm 5545 7 , , , cord-023095-4dannjjm 5545 8 with with IN cord-023095-4dannjjm 5545 9 a a DT cord-023095-4dannjjm 5545 10 median median JJ cord-023095-4dannjjm 5545 11 post post JJ cord-023095-4dannjjm 5545 12 CT CT NNP cord-023095-4dannjjm 5545 13 survival survival NN cord-023095-4dannjjm 5545 14 time time NN cord-023095-4dannjjm 5545 15 of of IN cord-023095-4dannjjm 5545 16 42 42 CD cord-023095-4dannjjm 5545 17 days day NNS cord-023095-4dannjjm 5545 18 ( ( -LRB- cord-023095-4dannjjm 5545 19 range range NNP cord-023095-4dannjjm 5545 20 2 2 CD cord-023095-4dannjjm 5545 21 - - SYM cord-023095-4dannjjm 5545 22 365 365 CD cord-023095-4dannjjm 5545 23 ) ) -RRB- cord-023095-4dannjjm 5545 24 , , , cord-023095-4dannjjm 5545 25 two two CD cord-023095-4dannjjm 5545 26 dogs dog NNS cord-023095-4dannjjm 5545 27 died die VBD cord-023095-4dannjjm 5545 28 of of IN cord-023095-4dannjjm 5545 29 non non JJ cord-023095-4dannjjm 5545 30 - - JJ cord-023095-4dannjjm 5545 31 pulmonary pulmonary JJ cord-023095-4dannjjm 5545 32 disease disease NN cord-023095-4dannjjm 5545 33 , , , cord-023095-4dannjjm 5545 34 2 2 CD cord-023095-4dannjjm 5545 35 dogs dog NNS cord-023095-4dannjjm 5545 36 had have VBD cord-023095-4dannjjm 5545 37 severe severe JJ cord-023095-4dannjjm 5545 38 lower low JJR cord-023095-4dannjjm 5545 39 respiratory respiratory JJ cord-023095-4dannjjm 5545 40 infections infection NNS cord-023095-4dannjjm 5545 41 as as IN cord-023095-4dannjjm 5545 42 puppies puppy NNS cord-023095-4dannjjm 5545 43 with with IN cord-023095-4dannjjm 5545 44 persistent persistent JJ cord-023095-4dannjjm 5545 45 respiratory respiratory JJ cord-023095-4dannjjm 5545 46 signs sign NNS cord-023095-4dannjjm 5545 47 , , , cord-023095-4dannjjm 5545 48 and and CC cord-023095-4dannjjm 5545 49 both both DT cord-023095-4dannjjm 5545 50 are be VBP cord-023095-4dannjjm 5545 51 still still RB cord-023095-4dannjjm 5545 52 alive alive JJ cord-023095-4dannjjm 5545 53 at at IN cord-023095-4dannjjm 5545 54 4 4 CD cord-023095-4dannjjm 5545 55 2 2 CD cord-023095-4dannjjm 5545 56 years year NNS cord-023095-4dannjjm 5545 57 since since IN cord-023095-4dannjjm 5545 58 diagnosis diagnosis NN cord-023095-4dannjjm 5545 59 , , , cord-023095-4dannjjm 5545 60 1 1 CD cord-023095-4dannjjm 5545 61 terrier terrier NN cord-023095-4dannjjm 5545 62 is be VBZ cord-023095-4dannjjm 5545 63 alive alive JJ cord-023095-4dannjjm 5545 64 at at IN cord-023095-4dannjjm 5545 65 19 19 CD cord-023095-4dannjjm 5545 66 months month NNS cord-023095-4dannjjm 5545 67 and and CC cord-023095-4dannjjm 5545 68 1 1 CD cord-023095-4dannjjm 5545 69 was be VBD cord-023095-4dannjjm 5545 70 lost lose VBN cord-023095-4dannjjm 5545 71 to to TO cord-023095-4dannjjm 5545 72 follow follow VB cord-023095-4dannjjm 5545 73 up up RP cord-023095-4dannjjm 5545 74 . . . cord-023095-4dannjjm 5546 1 5 5 CD cord-023095-4dannjjm 5546 2 dogs dog NNS cord-023095-4dannjjm 5546 3 had have VBD cord-023095-4dannjjm 5546 4 PHTN PHTN NNP cord-023095-4dannjjm 5546 5 , , , cord-023095-4dannjjm 5546 6 with with IN cord-023095-4dannjjm 5546 7 a a DT cord-023095-4dannjjm 5546 8 median median JJ cord-023095-4dannjjm 5546 9 survival survival NN cord-023095-4dannjjm 5546 10 of of IN cord-023095-4dannjjm 5546 11 60 60 CD cord-023095-4dannjjm 5546 12 days day NNS cord-023095-4dannjjm 5546 13 ( ( -LRB- cord-023095-4dannjjm 5546 14 42 42 CD cord-023095-4dannjjm 5546 15 - - SYM cord-023095-4dannjjm 5546 16 590 590 CD cord-023095-4dannjjm 5546 17 ) ) -RRB- cord-023095-4dannjjm 5546 18 , , , cord-023095-4dannjjm 5546 19 while while IN cord-023095-4dannjjm 5546 20 the the DT cord-023095-4dannjjm 5546 21 5 5 CD cord-023095-4dannjjm 5546 22 dogs dog NNS cord-023095-4dannjjm 5546 23 without without IN cord-023095-4dannjjm 5546 24 had have VBD cord-023095-4dannjjm 5546 25 a a DT cord-023095-4dannjjm 5546 26 survival survival NN cord-023095-4dannjjm 5546 27 of of IN cord-023095-4dannjjm 5546 28 180 180 CD cord-023095-4dannjjm 5546 29 days day NNS cord-023095-4dannjjm 5547 1 ( ( -LRB- cord-023095-4dannjjm 5547 2 range range NNP cord-023095-4dannjjm 5547 3 21 21 CD cord-023095-4dannjjm 5547 4 - - SYM cord-023095-4dannjjm 5547 5 730 730 CD cord-023095-4dannjjm 5547 6 ) ) -RRB- cord-023095-4dannjjm 5547 7 , , . cord-023095-4dannjjm 5548 1 [ [ -LRB- cord-023095-4dannjjm 5548 2 p p NN cord-023095-4dannjjm 5548 3 5 5 CD cord-023095-4dannjjm 5548 4 0.3 0.3 CD cord-023095-4dannjjm 5548 5 ] ] -RRB- cord-023095-4dannjjm 5548 6 . . . cord-023095-4dannjjm 5549 1 Interstitial interstitial JJ cord-023095-4dannjjm 5549 2 lung lung NN cord-023095-4dannjjm 5549 3 disease disease NN cord-023095-4dannjjm 5549 4 in in IN cord-023095-4dannjjm 5549 5 dogs dog NNS cord-023095-4dannjjm 5549 6 is be VBZ cord-023095-4dannjjm 5549 7 not not RB cord-023095-4dannjjm 5549 8 just just RB cord-023095-4dannjjm 5549 9 idiopathic idiopathic JJ cord-023095-4dannjjm 5549 10 pulmonary pulmonary JJ cord-023095-4dannjjm 5549 11 fibrosis fibrosis NN cord-023095-4dannjjm 5549 12 . . . cord-023095-4dannjjm 5550 1 Following follow VBG cord-023095-4dannjjm 5550 2 respiratory respiratory JJ cord-023095-4dannjjm 5550 3 infection infection NN cord-023095-4dannjjm 5550 4 , , , cord-023095-4dannjjm 5550 5 young young JJ cord-023095-4dannjjm 5550 6 dogs dog NNS cord-023095-4dannjjm 5550 7 may may MD cord-023095-4dannjjm 5550 8 develop develop VB cord-023095-4dannjjm 5550 9 an an DT cord-023095-4dannjjm 5550 10 ILD ILD NNP cord-023095-4dannjjm 5550 11 with with IN cord-023095-4dannjjm 5550 12 a a DT cord-023095-4dannjjm 5550 13 relatively relatively RB cord-023095-4dannjjm 5550 14 indolent indolent JJ cord-023095-4dannjjm 5550 15 course course NN cord-023095-4dannjjm 5550 16 and and CC cord-023095-4dannjjm 5550 17 rare rare JJ cord-023095-4dannjjm 5550 18 ILD ILD NNP cord-023095-4dannjjm 5550 19 is be VBZ cord-023095-4dannjjm 5550 20 steroid steroid NN cord-023095-4dannjjm 5550 21 responsive responsive JJ cord-023095-4dannjjm 5550 22 . . . cord-023095-4dannjjm 5551 1 CT CT NNP cord-023095-4dannjjm 5551 2 is be VBZ cord-023095-4dannjjm 5551 3 useful useful JJ cord-023095-4dannjjm 5551 4 to to TO cord-023095-4dannjjm 5551 5 identify identify VB cord-023095-4dannjjm 5551 6 ILD ILD NNP cord-023095-4dannjjm 5551 7 but but CC cord-023095-4dannjjm 5551 8 further further JJ cord-023095-4dannjjm 5551 9 research research NN cord-023095-4dannjjm 5551 10 correlated correlate VBN cord-023095-4dannjjm 5551 11 with with IN cord-023095-4dannjjm 5551 12 echocardiography echocardiography NN cord-023095-4dannjjm 5551 13 and and CC cord-023095-4dannjjm 5551 14 histopathology histopathology NN cord-023095-4dannjjm 5551 15 is be VBZ cord-023095-4dannjjm 5551 16 advised advise VBN cord-023095-4dannjjm 5551 17 to to TO cord-023095-4dannjjm 5551 18 use use VB cord-023095-4dannjjm 5551 19 it -PRON- PRP cord-023095-4dannjjm 5551 20 to to TO cord-023095-4dannjjm 5551 21 prognosticate prognosticate VB cord-023095-4dannjjm 5551 22 . . . cord-023095-4dannjjm 5552 1 Idiopathic idiopathic JJ cord-023095-4dannjjm 5552 2 pulmonary pulmonary JJ cord-023095-4dannjjm 5552 3 fibrosis fibrosis NN cord-023095-4dannjjm 5552 4 ( ( -LRB- cord-023095-4dannjjm 5552 5 IPF IPF NNP cord-023095-4dannjjm 5552 6 ) ) -RRB- cord-023095-4dannjjm 5552 7 is be VBZ cord-023095-4dannjjm 5552 8 an an DT cord-023095-4dannjjm 5552 9 interstitial interstitial JJ cord-023095-4dannjjm 5552 10 pulmonary pulmonary JJ cord-023095-4dannjjm 5552 11 disease disease NN cord-023095-4dannjjm 5552 12 , , , cord-023095-4dannjjm 5552 13 mainly mainly RB cord-023095-4dannjjm 5552 14 described describe VBN cord-023095-4dannjjm 5552 15 in in IN cord-023095-4dannjjm 5552 16 West West NNP cord-023095-4dannjjm 5552 17 Highland Highland NNP cord-023095-4dannjjm 5552 18 white white JJ cord-023095-4dannjjm 5552 19 terriers terrier NNS cord-023095-4dannjjm 5552 20 ( ( -LRB- cord-023095-4dannjjm 5552 21 WHWT WHWT NNP cord-023095-4dannjjm 5552 22 ) ) -RRB- cord-023095-4dannjjm 5552 23 . . . cord-023095-4dannjjm 5553 1 Identification identification NN cord-023095-4dannjjm 5553 2 of of IN cord-023095-4dannjjm 5553 3 molecular molecular JJ cord-023095-4dannjjm 5553 4 pathways pathway NNS cord-023095-4dannjjm 5553 5 important important JJ cord-023095-4dannjjm 5553 6 in in IN cord-023095-4dannjjm 5553 7 the the DT cord-023095-4dannjjm 5553 8 pathogenesis pathogenesis NN cord-023095-4dannjjm 5553 9 of of IN cord-023095-4dannjjm 5553 10 IPF IPF NNP cord-023095-4dannjjm 5553 11 would would MD cord-023095-4dannjjm 5553 12 improve improve VB cord-023095-4dannjjm 5553 13 our -PRON- PRP$ cord-023095-4dannjjm 5553 14 understanding understanding NN cord-023095-4dannjjm 5553 15 of of IN cord-023095-4dannjjm 5553 16 this this DT cord-023095-4dannjjm 5553 17 disease disease NN cord-023095-4dannjjm 5553 18 and and CC cord-023095-4dannjjm 5553 19 may may MD cord-023095-4dannjjm 5553 20 help help VB cord-023095-4dannjjm 5553 21 identify identify VB cord-023095-4dannjjm 5553 22 therapeutic therapeutic JJ cord-023095-4dannjjm 5553 23 targets target NNS cord-023095-4dannjjm 5553 24 . . . cord-023095-4dannjjm 5554 1 The the DT cord-023095-4dannjjm 5554 2 aim aim NN cord-023095-4dannjjm 5554 3 of of IN cord-023095-4dannjjm 5554 4 the the DT cord-023095-4dannjjm 5554 5 present present JJ cord-023095-4dannjjm 5554 6 study study NN cord-023095-4dannjjm 5554 7 was be VBD cord-023095-4dannjjm 5554 8 to to TO cord-023095-4dannjjm 5554 9 investigate investigate VB cord-023095-4dannjjm 5554 10 gene gene NN cord-023095-4dannjjm 5554 11 expression expression NN cord-023095-4dannjjm 5554 12 in in IN cord-023095-4dannjjm 5554 13 lungs lung NNS cord-023095-4dannjjm 5554 14 of of IN cord-023095-4dannjjm 5554 15 WHWT whwt NN cord-023095-4dannjjm 5554 16 with with IN cord-023095-4dannjjm 5554 17 IPF IPF NNP cord-023095-4dannjjm 5554 18 using use VBG cord-023095-4dannjjm 5554 19 oligonucleotide oligonucleotide JJ cord-023095-4dannjjm 5554 20 microarray microarray NN cord-023095-4dannjjm 5554 21 . . . cord-023095-4dannjjm 5555 1 Total Total NNP cord-023095-4dannjjm 5555 2 RNA RNA NNP cord-023095-4dannjjm 5555 3 was be VBD cord-023095-4dannjjm 5555 4 extracted extract VBN cord-023095-4dannjjm 5555 5 from from IN cord-023095-4dannjjm 5555 6 post post JJ cord-023095-4dannjjm 5555 7 - - JJ cord-023095-4dannjjm 5555 8 mortem mortem JJ cord-023095-4dannjjm 5555 9 pulmonary pulmonary JJ cord-023095-4dannjjm 5555 10 samples sample NNS cord-023095-4dannjjm 5555 11 from from IN cord-023095-4dannjjm 5555 12 five five CD cord-023095-4dannjjm 5555 13 WHWT WHWT NNS cord-023095-4dannjjm 5555 14 with with IN cord-023095-4dannjjm 5555 15 IPF IPF NNP cord-023095-4dannjjm 5555 16 and and CC cord-023095-4dannjjm 5555 17 five five CD cord-023095-4dannjjm 5555 18 control control NN cord-023095-4dannjjm 5555 19 dogs dog NNS cord-023095-4dannjjm 5555 20 ( ( -LRB- cord-023095-4dannjjm 5555 21 CTRL CTRL NNP cord-023095-4dannjjm 5555 22 ) ) -RRB- cord-023095-4dannjjm 5555 23 without without IN cord-023095-4dannjjm 5555 24 pulmonary pulmonary JJ cord-023095-4dannjjm 5555 25 disease disease NN cord-023095-4dannjjm 5555 26 . . . cord-023095-4dannjjm 5556 1 The the DT cord-023095-4dannjjm 5556 2 RNA RNA NNP cord-023095-4dannjjm 5556 3 was be VBD cord-023095-4dannjjm 5556 4 pooled pool VBN cord-023095-4dannjjm 5556 5 from from IN cord-023095-4dannjjm 5556 6 each each DT cord-023095-4dannjjm 5556 7 group group NN cord-023095-4dannjjm 5556 8 ( ( -LRB- cord-023095-4dannjjm 5556 9 IPF IPF NNP cord-023095-4dannjjm 5556 10 and and CC cord-023095-4dannjjm 5556 11 CTRL CTRL NNP cord-023095-4dannjjm 5556 12 ) ) -RRB- cord-023095-4dannjjm 5556 13 and and CC cord-023095-4dannjjm 5556 14 analysed analyse VBD cord-023095-4dannjjm 5556 15 using use VBG cord-023095-4dannjjm 5556 16 the the DT cord-023095-4dannjjm 5556 17 canine canine JJ cord-023095-4dannjjm 5556 18 specific specific JJ cord-023095-4dannjjm 5556 19 Affymetrix Affymetrix NNP cord-023095-4dannjjm 5556 20 microarray microarray NN cord-023095-4dannjjm 5556 21 technology technology NN cord-023095-4dannjjm 5556 22 . . . cord-023095-4dannjjm 5557 1 Genes gene NNS cord-023095-4dannjjm 5557 2 with with IN cord-023095-4dannjjm 5557 3 a a DT cord-023095-4dannjjm 5557 4 minimum minimum NN cord-023095-4dannjjm 5557 5 of of IN cord-023095-4dannjjm 5557 6 a a DT cord-023095-4dannjjm 5557 7 two two CD cord-023095-4dannjjm 5557 8 - - HYPH cord-023095-4dannjjm 5557 9 fold fold JJ cord-023095-4dannjjm 5557 10 difference difference NN cord-023095-4dannjjm 5557 11 in in IN cord-023095-4dannjjm 5557 12 expression expression NN cord-023095-4dannjjm 5557 13 between between IN cord-023095-4dannjjm 5557 14 the the DT cord-023095-4dannjjm 5557 15 two two CD cord-023095-4dannjjm 5557 16 groups group NNS cord-023095-4dannjjm 5557 17 were be VBD cord-023095-4dannjjm 5557 18 selected select VBN cord-023095-4dannjjm 5557 19 for for IN cord-023095-4dannjjm 5557 20 further further JJ cord-023095-4dannjjm 5557 21 analysis analysis NN cord-023095-4dannjjm 5557 22 . . . cord-023095-4dannjjm 5558 1 The the DT cord-023095-4dannjjm 5558 2 most most RBS cord-023095-4dannjjm 5558 3 significant significant JJ cord-023095-4dannjjm 5558 4 biological biological JJ cord-023095-4dannjjm 5558 5 functions function NNS cord-023095-4dannjjm 5558 6 for for IN cord-023095-4dannjjm 5558 7 these these DT cord-023095-4dannjjm 5558 8 genes gene NNS cord-023095-4dannjjm 5558 9 were be VBD cord-023095-4dannjjm 5558 10 identified identify VBN cord-023095-4dannjjm 5558 11 using use VBG cord-023095-4dannjjm 5558 12 Ingenuity Ingenuity NNP cord-023095-4dannjjm 5558 13 Pathways Pathways NNP cord-023095-4dannjjm 5558 14 Analysis Analysis NNP cord-023095-4dannjjm 5558 15 . . . cord-023095-4dannjjm 5559 1 More More JJR cord-023095-4dannjjm 5559 2 than than IN cord-023095-4dannjjm 5559 3 1000 1000 CD cord-023095-4dannjjm 5559 4 genes gene NNS cord-023095-4dannjjm 5559 5 were be VBD cord-023095-4dannjjm 5559 6 identified identify VBN cord-023095-4dannjjm 5559 7 as as IN cord-023095-4dannjjm 5559 8 having have VBG cord-023095-4dannjjm 5559 9 greater great JJR cord-023095-4dannjjm 5559 10 than than IN cord-023095-4dannjjm 5559 11 twofold twofold JJ cord-023095-4dannjjm 5559 12 difference difference NN cord-023095-4dannjjm 5559 13 in in IN cord-023095-4dannjjm 5559 14 expression expression NN cord-023095-4dannjjm 5559 15 . . . cord-023095-4dannjjm 5560 1 The the DT cord-023095-4dannjjm 5560 2 significant significant JJ cord-023095-4dannjjm 5560 3 biological biological JJ cord-023095-4dannjjm 5560 4 functions function NNS cord-023095-4dannjjm 5560 5 associated associate VBN cord-023095-4dannjjm 5560 6 with with IN cord-023095-4dannjjm 5560 7 these these DT cord-023095-4dannjjm 5560 8 genes gene NNS cord-023095-4dannjjm 5560 9 were be VBD cord-023095-4dannjjm 5560 10 related relate VBN cord-023095-4dannjjm 5560 11 to to IN cord-023095-4dannjjm 5560 12 cellular cellular JJ cord-023095-4dannjjm 5560 13 movement movement NN cord-023095-4dannjjm 5560 14 , , , cord-023095-4dannjjm 5560 15 cellular cellular JJ cord-023095-4dannjjm 5560 16 proliferation proliferation NN cord-023095-4dannjjm 5560 17 and and CC cord-023095-4dannjjm 5560 18 apoptosis apoptosis NN cord-023095-4dannjjm 5560 19 . . . cord-023095-4dannjjm 5561 1 Most most RBS cord-023095-4dannjjm 5561 2 notable notable JJ cord-023095-4dannjjm 5561 3 among among IN cord-023095-4dannjjm 5561 4 these these DT cord-023095-4dannjjm 5561 5 were be VBD cord-023095-4dannjjm 5561 6 genes gene NNS cord-023095-4dannjjm 5561 7 encoding encode VBG cord-023095-4dannjjm 5561 8 the the DT cord-023095-4dannjjm 5561 9 leukocyte leukocyte NN cord-023095-4dannjjm 5561 10 chemotactic chemotactic JJ cord-023095-4dannjjm 5561 11 proteins protein NNS cord-023095-4dannjjm 5561 12 : : : cord-023095-4dannjjm 5561 13 CCL2 CCL2 NNP cord-023095-4dannjjm 5561 14 ( ( -LRB- cord-023095-4dannjjm 5561 15 fold fold VB cord-023095-4dannjjm 5561 16 change change NN cord-023095-4dannjjm 5561 17 14.93 14.93 CD cord-023095-4dannjjm 5561 18 ) ) -RRB- cord-023095-4dannjjm 5561 19 , , , cord-023095-4dannjjm 5561 20 CCL17 CCL17 NNP cord-023095-4dannjjm 5561 21 ( ( -LRB- cord-023095-4dannjjm 5561 22 12.74 12.74 CD cord-023095-4dannjjm 5561 23 ) ) -RRB- cord-023095-4dannjjm 5561 24 and and CC cord-023095-4dannjjm 5561 25 IL8 IL8 NNP cord-023095-4dannjjm 5561 26 ( ( -LRB- cord-023095-4dannjjm 5561 27 14.32 14.32 CD cord-023095-4dannjjm 5561 28 ) ) -RRB- cord-023095-4dannjjm 5561 29 ; ; : cord-023095-4dannjjm 5561 30 the the DT cord-023095-4dannjjm 5561 31 proteins protein NNS cord-023095-4dannjjm 5561 32 involved involve VBN cord-023095-4dannjjm 5561 33 in in IN cord-023095-4dannjjm 5561 34 fibroblast fibroblast NN cord-023095-4dannjjm 5561 35 migration migration NN cord-023095-4dannjjm 5561 36 ; ; , cord-023095-4dannjjm 5561 37 and and CC cord-023095-4dannjjm 5561 38 the the DT cord-023095-4dannjjm 5561 39 matrix matrix NN cord-023095-4dannjjm 5561 40 metalloproteinases metalloproteinase NNS cord-023095-4dannjjm 5561 41 ( ( -LRB- cord-023095-4dannjjm 5561 42 MMPs MMPs NNP cord-023095-4dannjjm 5561 43 ) ) -RRB- cord-023095-4dannjjm 5561 44 involved involve VBN cord-023095-4dannjjm 5561 45 in in IN cord-023095-4dannjjm 5561 46 matrix matrix NN cord-023095-4dannjjm 5561 47 degradation degradation NN cord-023095-4dannjjm 5561 48 : : : cord-023095-4dannjjm 5561 49 MMP7 MMP7 NNP cord-023095-4dannjjm 5561 50 ( ( -LRB- cord-023095-4dannjjm 5561 51 À17.55 à17.55 CD cord-023095-4dannjjm 5561 52 ) ) -RRB- cord-023095-4dannjjm 5561 53 , , , cord-023095-4dannjjm 5561 54 MMP9 MMP9 NNP cord-023095-4dannjjm 5561 55 ( ( -LRB- cord-023095-4dannjjm 5561 56 -3.42 -3.42 CD cord-023095-4dannjjm 5561 57 ) ) -RRB- cord-023095-4dannjjm 5561 58 , , , cord-023095-4dannjjm 5561 59 MMP1 MMP1 NNP cord-023095-4dannjjm 5561 60 ( ( -LRB- cord-023095-4dannjjm 5561 61 À2.76 À2.76 NNP cord-023095-4dannjjm 5561 62 ) ) -RRB- cord-023095-4dannjjm 5561 63 . . . cord-023095-4dannjjm 5562 1 This this DT cord-023095-4dannjjm 5562 2 study study NN cord-023095-4dannjjm 5562 3 has have VBZ cord-023095-4dannjjm 5562 4 identified identify VBN cord-023095-4dannjjm 5562 5 genes gene NNS cord-023095-4dannjjm 5562 6 which which WDT cord-023095-4dannjjm 5562 7 may may MD cord-023095-4dannjjm 5562 8 be be VB cord-023095-4dannjjm 5562 9 important important JJ cord-023095-4dannjjm 5562 10 in in IN cord-023095-4dannjjm 5562 11 pathogenesis pathogenesis NN cord-023095-4dannjjm 5562 12 of of IN cord-023095-4dannjjm 5562 13 IPF IPF NNP cord-023095-4dannjjm 5562 14 , , , cord-023095-4dannjjm 5562 15 e.g. e.g. RB cord-023095-4dannjjm 5562 16 proteins protein NNS cord-023095-4dannjjm 5562 17 involved involve VBN cord-023095-4dannjjm 5562 18 in in IN cord-023095-4dannjjm 5562 19 leukocytes leukocyte NNS cord-023095-4dannjjm 5562 20 chemotaxis chemotaxis NN cord-023095-4dannjjm 5562 21 , , , cord-023095-4dannjjm 5562 22 fibroblast fibroblast NN cord-023095-4dannjjm 5562 23 recruitment recruitment NN cord-023095-4dannjjm 5562 24 and and CC cord-023095-4dannjjm 5562 25 activation activation NN cord-023095-4dannjjm 5562 26 , , , cord-023095-4dannjjm 5562 27 regulation regulation NN cord-023095-4dannjjm 5562 28 of of IN cord-023095-4dannjjm 5562 29 apoptosis apoptosis NN cord-023095-4dannjjm 5562 30 , , , cord-023095-4dannjjm 5562 31 and and CC cord-023095-4dannjjm 5562 32 extracellular extracellular JJ cord-023095-4dannjjm 5562 33 - - HYPH cord-023095-4dannjjm 5562 34 matrix matrix NN cord-023095-4dannjjm 5562 35 turn turn NN cord-023095-4dannjjm 5562 36 - - HYPH cord-023095-4dannjjm 5562 37 over over NN cord-023095-4dannjjm 5562 38 . . . cord-023095-4dannjjm 5563 1 However however RB cord-023095-4dannjjm 5563 2 , , , cord-023095-4dannjjm 5563 3 real real JJ cord-023095-4dannjjm 5563 4 - - HYPH cord-023095-4dannjjm 5563 5 time time NN cord-023095-4dannjjm 5563 6 quantitative quantitative JJ cord-023095-4dannjjm 5563 7 RT RT NNP cord-023095-4dannjjm 5563 8 - - HYPH cord-023095-4dannjjm 5563 9 PCR PCR NNP cord-023095-4dannjjm 5563 10 studies study NNS cord-023095-4dannjjm 5563 11 are be VBP cord-023095-4dannjjm 5563 12 needed need VBN cord-023095-4dannjjm 5563 13 to to TO cord-023095-4dannjjm 5563 14 confirm confirm VB cord-023095-4dannjjm 5563 15 these these DT cord-023095-4dannjjm 5563 16 results result NNS cord-023095-4dannjjm 5563 17 before before IN cord-023095-4dannjjm 5563 18 any any DT cord-023095-4dannjjm 5563 19 definitive definitive JJ cord-023095-4dannjjm 5563 20 conclusions conclusion NNS cord-023095-4dannjjm 5563 21 can can MD cord-023095-4dannjjm 5563 22 be be VB cord-023095-4dannjjm 5563 23 drawn draw VBN cord-023095-4dannjjm 5563 24 . . . cord-023095-4dannjjm 5564 1 Idiopathic idiopathic JJ cord-023095-4dannjjm 5564 2 pulmonary pulmonary JJ cord-023095-4dannjjm 5564 3 fibrosis fibrosis NN cord-023095-4dannjjm 5564 4 ( ( -LRB- cord-023095-4dannjjm 5564 5 IPF IPF NNP cord-023095-4dannjjm 5564 6 ) ) -RRB- cord-023095-4dannjjm 5564 7 is be VBZ cord-023095-4dannjjm 5564 8 an an DT cord-023095-4dannjjm 5564 9 interstitial interstitial JJ cord-023095-4dannjjm 5564 10 disease disease NN cord-023095-4dannjjm 5564 11 , , , cord-023095-4dannjjm 5564 12 mainly mainly RB cord-023095-4dannjjm 5564 13 described describe VBN cord-023095-4dannjjm 5564 14 in in IN cord-023095-4dannjjm 5564 15 West West NNP cord-023095-4dannjjm 5564 16 Highland Highland NNP cord-023095-4dannjjm 5564 17 white white JJ cord-023095-4dannjjm 5564 18 terriers terrier NNS cord-023095-4dannjjm 5564 19 ( ( -LRB- cord-023095-4dannjjm 5564 20 WHWT WHWT NNP cord-023095-4dannjjm 5564 21 ) ) -RRB- cord-023095-4dannjjm 5564 22 . . . cord-023095-4dannjjm 5565 1 Defini Defini NNP cord-023095-4dannjjm 5565 2 - - HYPH cord-023095-4dannjjm 5565 3 tive tive JJ cord-023095-4dannjjm 5565 4 diagnosis diagnosis NN cord-023095-4dannjjm 5565 5 ultimately ultimately RB cord-023095-4dannjjm 5565 6 relies rely VBZ cord-023095-4dannjjm 5565 7 on on IN cord-023095-4dannjjm 5565 8 lung lung NN cord-023095-4dannjjm 5565 9 histopathology histopathology NN cord-023095-4dannjjm 5565 10 . . . cord-023095-4dannjjm 5566 1 Identification identification NN cord-023095-4dannjjm 5566 2 of of IN cord-023095-4dannjjm 5566 3 specific specific JJ cord-023095-4dannjjm 5566 4 biomarkers biomarker NNS cord-023095-4dannjjm 5566 5 would would MD cord-023095-4dannjjm 5566 6 be be VB cord-023095-4dannjjm 5566 7 very very RB cord-023095-4dannjjm 5566 8 helpful helpful JJ cord-023095-4dannjjm 5566 9 . . . cord-023095-4dannjjm 5567 1 Expression expression NN cord-023095-4dannjjm 5567 2 microarray microarray NN cord-023095-4dannjjm 5567 3 is be VBZ cord-023095-4dannjjm 5567 4 a a DT cord-023095-4dannjjm 5567 5 powerful powerful JJ cord-023095-4dannjjm 5567 6 screening screening NN cord-023095-4dannjjm 5567 7 tool tool NN cord-023095-4dannjjm 5567 8 to to TO cord-023095-4dannjjm 5567 9 study study VB cord-023095-4dannjjm 5567 10 local local JJ cord-023095-4dannjjm 5567 11 gene gene NN cord-023095-4dannjjm 5567 12 expression expression NN cord-023095-4dannjjm 5567 13 in in IN cord-023095-4dannjjm 5567 14 a a DT cord-023095-4dannjjm 5567 15 disease disease NN cord-023095-4dannjjm 5567 16 state state NN cord-023095-4dannjjm 5567 17 . . . cord-023095-4dannjjm 5568 1 The the DT cord-023095-4dannjjm 5568 2 aim aim NN cord-023095-4dannjjm 5568 3 of of IN cord-023095-4dannjjm 5568 4 the the DT cord-023095-4dannjjm 5568 5 present present JJ cord-023095-4dannjjm 5568 6 study study NN cord-023095-4dannjjm 5568 7 was be VBD cord-023095-4dannjjm 5568 8 to to TO cord-023095-4dannjjm 5568 9 measure measure VB cord-023095-4dannjjm 5568 10 gene gene NN cord-023095-4dannjjm 5568 11 expression expression NN cord-023095-4dannjjm 5568 12 profiles profile NNS cord-023095-4dannjjm 5568 13 in in IN cord-023095-4dannjjm 5568 14 lungs lung NNS cord-023095-4dannjjm 5568 15 of of IN cord-023095-4dannjjm 5568 16 WHWT whwt NN cord-023095-4dannjjm 5568 17 with with IN cord-023095-4dannjjm 5568 18 IPF IPF NNP cord-023095-4dannjjm 5568 19 to to TO cord-023095-4dannjjm 5568 20 identify identify VB cord-023095-4dannjjm 5568 21 potential potential JJ cord-023095-4dannjjm 5568 22 blood blood NN cord-023095-4dannjjm 5568 23 or or CC cord-023095-4dannjjm 5568 24 bronchoalveolar bronchoalveolar NNP cord-023095-4dannjjm 5568 25 lavage lavage NN cord-023095-4dannjjm 5568 26 fluid fluid NN cord-023095-4dannjjm 5568 27 ( ( -LRB- cord-023095-4dannjjm 5568 28 BALF BALF NNP cord-023095-4dannjjm 5568 29 ) ) -RRB- cord-023095-4dannjjm 5568 30 biomarkers biomarker NNS cord-023095-4dannjjm 5568 31 . . . cord-023095-4dannjjm 5569 1 Total Total NNP cord-023095-4dannjjm 5569 2 RNA RNA NNP cord-023095-4dannjjm 5569 3 was be VBD cord-023095-4dannjjm 5569 4 extracted extract VBN cord-023095-4dannjjm 5569 5 from from IN cord-023095-4dannjjm 5569 6 post post JJ cord-023095-4dannjjm 5569 7 - - JJ cord-023095-4dannjjm 5569 8 mortem mortem JJ cord-023095-4dannjjm 5569 9 pulmonary pulmonary JJ cord-023095-4dannjjm 5569 10 samples sample NNS cord-023095-4dannjjm 5569 11 from from IN cord-023095-4dannjjm 5569 12 five five CD cord-023095-4dannjjm 5569 13 WHWT WHWT NNS cord-023095-4dannjjm 5569 14 with with IN cord-023095-4dannjjm 5569 15 histopathologically histopathologically RB cord-023095-4dannjjm 5569 16 confirmed confirm VBN cord-023095-4dannjjm 5569 17 IPF IPF NNP cord-023095-4dannjjm 5569 18 and and CC cord-023095-4dannjjm 5569 19 five five CD cord-023095-4dannjjm 5569 20 control control NN cord-023095-4dannjjm 5569 21 dogs dog NNS cord-023095-4dannjjm 5569 22 ( ( -LRB- cord-023095-4dannjjm 5569 23 CTRL CTRL NNP cord-023095-4dannjjm 5569 24 ) ) -RRB- cord-023095-4dannjjm 5569 25 without without IN cord-023095-4dannjjm 5569 26 pulmonary pulmonary JJ cord-023095-4dannjjm 5569 27 disease disease NN cord-023095-4dannjjm 5569 28 . . . cord-023095-4dannjjm 5570 1 The the DT cord-023095-4dannjjm 5570 2 RNA RNA NNP cord-023095-4dannjjm 5570 3 was be VBD cord-023095-4dannjjm 5570 4 pooled pool VBN cord-023095-4dannjjm 5570 5 from from IN cord-023095-4dannjjm 5570 6 each each DT cord-023095-4dannjjm 5570 7 group group NN cord-023095-4dannjjm 5570 8 ( ( -LRB- cord-023095-4dannjjm 5570 9 IPF IPF NNP cord-023095-4dannjjm 5570 10 and and CC cord-023095-4dannjjm 5570 11 CTRL CTRL NNP cord-023095-4dannjjm 5570 12 ) ) -RRB- cord-023095-4dannjjm 5570 13 and and CC cord-023095-4dannjjm 5570 14 analysed analyse VBD cord-023095-4dannjjm 5570 15 using use VBG cord-023095-4dannjjm 5570 16 the the DT cord-023095-4dannjjm 5570 17 canine canine JJ cord-023095-4dannjjm 5570 18 specific specific JJ cord-023095-4dannjjm 5570 19 Affymetrix Affymetrix NNP cord-023095-4dannjjm 5570 20 microarray microarray NN cord-023095-4dannjjm 5570 21 technology technology NN cord-023095-4dannjjm 5570 22 . . . cord-023095-4dannjjm 5571 1 IPA IPA NNP cord-023095-4dannjjm 5571 2 - - HYPH cord-023095-4dannjjm 5571 3 Biomarkers Biomarkers NNPS cord-023095-4dannjjm 5571 4 Analysis Analysis NNP cord-023095-4dannjjm 5571 5 ( ( -LRB- cord-023095-4dannjjm 5571 6 Ingenuity Ingenuity NNP cord-023095-4dannjjm 5571 7 System System NNP cord-023095-4dannjjm 5571 8 ) ) -RRB- cord-023095-4dannjjm 5571 9 was be VBD cord-023095-4dannjjm 5571 10 used use VBN cord-023095-4dannjjm 5571 11 to to TO cord-023095-4dannjjm 5571 12 filter filter VB cord-023095-4dannjjm 5571 13 and and CC cord-023095-4dannjjm 5571 14 prioritize prioritize VB cord-023095-4dannjjm 5571 15 biomarkers biomarker NNS cord-023095-4dannjjm 5571 16 candidates candidate NNS cord-023095-4dannjjm 5571 17 using use VBG cord-023095-4dannjjm 5571 18 the the DT cord-023095-4dannjjm 5571 19 three three CD cord-023095-4dannjjm 5571 20 following follow VBG cord-023095-4dannjjm 5571 21 criteria criterion NNS cord-023095-4dannjjm 5571 22 : : : cord-023095-4dannjjm 5571 23 a a DT cord-023095-4dannjjm 5571 24 minimum minimum NN cord-023095-4dannjjm 5571 25 of of IN cord-023095-4dannjjm 5571 26 a a DT cord-023095-4dannjjm 5571 27 two two CD cord-023095-4dannjjm 5571 28 - - HYPH cord-023095-4dannjjm 5571 29 fold fold JJ cord-023095-4dannjjm 5571 30 difference difference NN cord-023095-4dannjjm 5571 31 in in IN cord-023095-4dannjjm 5571 32 expression expression NN cord-023095-4dannjjm 5571 33 between between IN cord-023095-4dannjjm 5571 34 IPF IPF NNP cord-023095-4dannjjm 5571 35 and and CC cord-023095-4dannjjm 5571 36 CTRL ctrl NN cord-023095-4dannjjm 5571 37 ; ; : cord-023095-4dannjjm 5571 38 expression expression NN cord-023095-4dannjjm 5571 39 of of IN cord-023095-4dannjjm 5571 40 the the DT cord-023095-4dannjjm 5571 41 gene gene NN cord-023095-4dannjjm 5571 42 in in IN cord-023095-4dannjjm 5571 43 lung lung NN cord-023095-4dannjjm 5571 44 tissue tissue NN cord-023095-4dannjjm 5571 45 ; ; : cord-023095-4dannjjm 5571 46 possible possible JJ cord-023095-4dannjjm 5571 47 detection detection NN cord-023095-4dannjjm 5571 48 of of IN cord-023095-4dannjjm 5571 49 the the DT cord-023095-4dannjjm 5571 50 protein protein NN cord-023095-4dannjjm 5571 51 in in IN cord-023095-4dannjjm 5571 52 blood blood NN cord-023095-4dannjjm 5571 53 or or CC cord-023095-4dannjjm 5571 54 in in IN cord-023095-4dannjjm 5571 55 BALF BALF NNP cord-023095-4dannjjm 5571 56 . . . cord-023095-4dannjjm 5572 1 Fifty fifty CD cord-023095-4dannjjm 5572 2 - - HYPH cord-023095-4dannjjm 5572 3 four four CD cord-023095-4dannjjm 5572 4 molecules molecule NNS cord-023095-4dannjjm 5572 5 met meet VBD cord-023095-4dannjjm 5572 6 all all PDT cord-023095-4dannjjm 5572 7 the the DT cord-023095-4dannjjm 5572 8 criteria criterion NNS cord-023095-4dannjjm 5572 9 . . . cord-023095-4dannjjm 5573 1 Based base VBN cord-023095-4dannjjm 5573 2 on on IN cord-023095-4dannjjm 5573 3 difference difference NN cord-023095-4dannjjm 5573 4 in in IN cord-023095-4dannjjm 5573 5 expression expression NN cord-023095-4dannjjm 5573 6 , , , cord-023095-4dannjjm 5573 7 promising promise VBG cord-023095-4dannjjm 5573 8 proteins protein NNS cord-023095-4dannjjm 5573 9 included include VBD cord-023095-4dannjjm 5573 10 CCL7 CCL7 NNP cord-023095-4dannjjm 5573 11 ( ( -LRB- cord-023095-4dannjjm 5573 12 fold fold VB cord-023095-4dannjjm 5573 13 change change NN cord-023095-4dannjjm 5573 14 17.8 17.8 CD cord-023095-4dannjjm 5573 15 ) ) -RRB- cord-023095-4dannjjm 5573 16 , , , cord-023095-4dannjjm 5573 17 a3-Actinin a3-Actinin NNP cord-023095-4dannjjm 5573 18 ( ( -LRB- cord-023095-4dannjjm 5573 19 15.7 15.7 CD cord-023095-4dannjjm 5573 20 ) ) -RRB- cord-023095-4dannjjm 5573 21 , , , cord-023095-4dannjjm 5573 22 CCL2 CCL2 NNP cord-023095-4dannjjm 5573 23 ( ( -LRB- cord-023095-4dannjjm 5573 24 14.9 14.9 CD cord-023095-4dannjjm 5573 25 ) ) -RRB- cord-023095-4dannjjm 5573 26 , , , cord-023095-4dannjjm 5573 27 Serum Serum NNP cord-023095-4dannjjm 5573 28 Amyloid Amyloid NNP cord-023095-4dannjjm 5573 29 A1 A1 NNP cord-023095-4dannjjm 5573 30 ( ( -LRB- cord-023095-4dannjjm 5573 31 14.4 14.4 CD cord-023095-4dannjjm 5573 32 ) ) -RRB- cord-023095-4dannjjm 5573 33 , , , cord-023095-4dannjjm 5573 34 IL8 IL8 NNP cord-023095-4dannjjm 5573 35 ( ( -LRB- cord-023095-4dannjjm 5573 36 14.3 14.3 CD cord-023095-4dannjjm 5573 37 ) ) -RRB- cord-023095-4dannjjm 5573 38 , , , cord-023095-4dannjjm 5573 39 PLUNC PLUNC NNP cord-023095-4dannjjm 5573 40 ( ( -LRB- cord-023095-4dannjjm 5573 41 À25.1 à25.1 CD cord-023095-4dannjjm 5573 42 ) ) -RRB- cord-023095-4dannjjm 5573 43 , , , cord-023095-4dannjjm 5573 44 MMP7 MMP7 NNP cord-023095-4dannjjm 5573 45 ( ( -LRB- cord-023095-4dannjjm 5573 46 À17.6 à17.6 CD cord-023095-4dannjjm 5573 47 ) ) -RRB- cord-023095-4dannjjm 5573 48 . . . cord-023095-4dannjjm 5574 1 Some some DT cord-023095-4dannjjm 5574 2 are be VBP cord-023095-4dannjjm 5574 3 well well RB cord-023095-4dannjjm 5574 4 - - HYPH cord-023095-4dannjjm 5574 5 known know VBN cord-023095-4dannjjm 5574 6 biomarkers biomarker NNS cord-023095-4dannjjm 5574 7 of of IN cord-023095-4dannjjm 5574 8 IPF IPF NNP cord-023095-4dannjjm 5574 9 in in IN cord-023095-4dannjjm 5574 10 humans human NNS cord-023095-4dannjjm 5574 11 either either CC cord-023095-4dannjjm 5574 12 for for IN cord-023095-4dannjjm 5574 13 diagnosis diagnosis NN cord-023095-4dannjjm 5574 14 ( ( -LRB- cord-023095-4dannjjm 5574 15 MMP7 MMP7 NNP cord-023095-4dannjjm 5574 16 , , , cord-023095-4dannjjm 5574 17 IL8 il8 NN cord-023095-4dannjjm 5574 18 ) ) -RRB- cord-023095-4dannjjm 5574 19 or or CC cord-023095-4dannjjm 5574 20 prognosis prognosis NN cord-023095-4dannjjm 5574 21 ( ( -LRB- cord-023095-4dannjjm 5574 22 CCL2 CCL2 NNP cord-023095-4dannjjm 5574 23 ) ) -RRB- cord-023095-4dannjjm 5574 24 . . . cord-023095-4dannjjm 5575 1 These these DT cord-023095-4dannjjm 5575 2 results result NNS cord-023095-4dannjjm 5575 3 provide provide VBP cord-023095-4dannjjm 5575 4 novel novel JJ cord-023095-4dannjjm 5575 5 potential potential JJ cord-023095-4dannjjm 5575 6 biomarkers biomarker NNS cord-023095-4dannjjm 5575 7 of of IN cord-023095-4dannjjm 5575 8 canine canine JJ cord-023095-4dannjjm 5575 9 IPF IPF NNP cord-023095-4dannjjm 5575 10 . . . cord-023095-4dannjjm 5576 1 Measurement measurement NN cord-023095-4dannjjm 5576 2 of of IN cord-023095-4dannjjm 5576 3 these these DT cord-023095-4dannjjm 5576 4 proteins protein NNS cord-023095-4dannjjm 5576 5 in in IN cord-023095-4dannjjm 5576 6 blood blood NN cord-023095-4dannjjm 5576 7 and and CC cord-023095-4dannjjm 5576 8 BALF BALF NNP cord-023095-4dannjjm 5576 9 of of IN cord-023095-4dannjjm 5576 10 healthy healthy JJ cord-023095-4dannjjm 5576 11 dogs dog NNS cord-023095-4dannjjm 5576 12 , , , cord-023095-4dannjjm 5576 13 dogs dog NNS cord-023095-4dannjjm 5576 14 with with IN cord-023095-4dannjjm 5576 15 IPF IPF NNP cord-023095-4dannjjm 5576 16 and and CC cord-023095-4dannjjm 5576 17 with with IN cord-023095-4dannjjm 5576 18 other other JJ cord-023095-4dannjjm 5576 19 respiratory respiratory JJ cord-023095-4dannjjm 5576 20 diseases disease NNS cord-023095-4dannjjm 5576 21 is be VBZ cord-023095-4dannjjm 5576 22 needed need VBN cord-023095-4dannjjm 5576 23 to to TO cord-023095-4dannjjm 5576 24 assess assess VB cord-023095-4dannjjm 5576 25 their -PRON- PRP$ cord-023095-4dannjjm 5576 26 use use NN cord-023095-4dannjjm 5576 27 as as IN cord-023095-4dannjjm 5576 28 biomarkers biomarker NNS cord-023095-4dannjjm 5576 29 of of IN cord-023095-4dannjjm 5576 30 canine canine JJ cord-023095-4dannjjm 5576 31 IPF IPF NNP cord-023095-4dannjjm 5576 32 . . . cord-023095-4dannjjm 5577 1 Heliox Heliox NNP cord-023095-4dannjjm 5577 2 is be VBZ cord-023095-4dannjjm 5577 3 a a DT cord-023095-4dannjjm 5577 4 mixture mixture NN cord-023095-4dannjjm 5577 5 of of IN cord-023095-4dannjjm 5577 6 helium helium NN cord-023095-4dannjjm 5577 7 and and CC cord-023095-4dannjjm 5577 8 oxygen oxygen NN cord-023095-4dannjjm 5577 9 that that WDT cord-023095-4dannjjm 5577 10 has have VBZ cord-023095-4dannjjm 5577 11 been be VBN cord-023095-4dannjjm 5577 12 used use VBN cord-023095-4dannjjm 5577 13 therapeutically therapeutically RB cord-023095-4dannjjm 5577 14 in in IN cord-023095-4dannjjm 5577 15 human human JJ cord-023095-4dannjjm 5577 16 medicine medicine NN cord-023095-4dannjjm 5577 17 for for IN cord-023095-4dannjjm 5577 18 treatment treatment NN cord-023095-4dannjjm 5577 19 of of IN cord-023095-4dannjjm 5577 20 airway airway JJ cord-023095-4dannjjm 5577 21 obstruction obstruction NN cord-023095-4dannjjm 5577 22 . . . cord-023095-4dannjjm 5578 1 Helium helium NN cord-023095-4dannjjm 5578 2 's 's POS cord-023095-4dannjjm 5578 3 low low JJ cord-023095-4dannjjm 5578 4 density density NN cord-023095-4dannjjm 5578 5 and and CC cord-023095-4dannjjm 5578 6 other other JJ cord-023095-4dannjjm 5578 7 physical physical JJ cord-023095-4dannjjm 5578 8 properties property NNS cord-023095-4dannjjm 5578 9 have have VBP cord-023095-4dannjjm 5578 10 been be VBN cord-023095-4dannjjm 5578 11 shown show VBN cord-023095-4dannjjm 5578 12 to to TO cord-023095-4dannjjm 5578 13 reduce reduce VB cord-023095-4dannjjm 5578 14 the the DT cord-023095-4dannjjm 5578 15 work work NN cord-023095-4dannjjm 5578 16 of of IN cord-023095-4dannjjm 5578 17 breathing breathe VBG cord-023095-4dannjjm 5578 18 by by IN cord-023095-4dannjjm 5578 19 limiting limit VBG cord-023095-4dannjjm 5578 20 turbulence turbulence NN cord-023095-4dannjjm 5578 21 . . . cord-023095-4dannjjm 5579 1 The the DT cord-023095-4dannjjm 5579 2 purpose purpose NN cord-023095-4dannjjm 5579 3 of of IN cord-023095-4dannjjm 5579 4 this this DT cord-023095-4dannjjm 5579 5 study study NN cord-023095-4dannjjm 5579 6 was be VBD cord-023095-4dannjjm 5579 7 , , , cord-023095-4dannjjm 5579 8 therefore therefore RB cord-023095-4dannjjm 5579 9 , , , cord-023095-4dannjjm 5579 10 to to TO cord-023095-4dannjjm 5579 11 evaluate evaluate VB cord-023095-4dannjjm 5579 12 respiratory respiratory JJ cord-023095-4dannjjm 5579 13 parameters parameter NNS cord-023095-4dannjjm 5579 14 in in IN cord-023095-4dannjjm 5579 15 response response NN cord-023095-4dannjjm 5579 16 to to IN cord-023095-4dannjjm 5579 17 inhaled inhale VBN cord-023095-4dannjjm 5579 18 heliox heliox NN cord-023095-4dannjjm 5579 19 in in IN cord-023095-4dannjjm 5579 20 dogs dog NNS cord-023095-4dannjjm 5579 21 with with IN cord-023095-4dannjjm 5579 22 meso meso NNP cord-023095-4dannjjm 5579 23 - - HYPH cord-023095-4dannjjm 5579 24 and and CC cord-023095-4dannjjm 5579 25 brachycephalic brachycephalic JJ cord-023095-4dannjjm 5579 26 conformation conformation NN cord-023095-4dannjjm 5579 27 . . . cord-023095-4dannjjm 5580 1 Eleven eleven CD cord-023095-4dannjjm 5580 2 healthy healthy JJ cord-023095-4dannjjm 5580 3 dogs dog NNS cord-023095-4dannjjm 5580 4 were be VBD cord-023095-4dannjjm 5580 5 recruited recruit VBN cord-023095-4dannjjm 5580 6 , , , cord-023095-4dannjjm 5580 7 five five CD cord-023095-4dannjjm 5580 8 were be VBD cord-023095-4dannjjm 5580 9 mesocephalic mesocephalic JJ cord-023095-4dannjjm 5580 10 and and CC cord-023095-4dannjjm 5580 11 six six CD cord-023095-4dannjjm 5580 12 were be VBD cord-023095-4dannjjm 5580 13 brachycephalic brachycephalic JJ cord-023095-4dannjjm 5580 14 . . . cord-023095-4dannjjm 5581 1 Flow flow NN cord-023095-4dannjjm 5581 2 - - HYPH cord-023095-4dannjjm 5581 3 volume volume NN cord-023095-4dannjjm 5581 4 loops loop NNS cord-023095-4dannjjm 5581 5 were be VBD cord-023095-4dannjjm 5581 6 collected collect VBN cord-023095-4dannjjm 5581 7 using use VBG cord-023095-4dannjjm 5581 8 commercial commercial JJ cord-023095-4dannjjm 5581 9 software software NN cord-023095-4dannjjm 5581 10 ( ( -LRB- cord-023095-4dannjjm 5581 11 Buxcor Buxcor NNP cord-023095-4dannjjm 5581 12 ) ) -RRB- cord-023095-4dannjjm 5581 13 while while IN cord-023095-4dannjjm 5581 14 breathing breathe VBG cord-023095-4dannjjm 5581 15 70:30 70:30 NNP cord-023095-4dannjjm 5581 16 Helium Helium NNP cord-023095-4dannjjm 5581 17 : : : cord-023095-4dannjjm 5581 18 oxygen oxygen NN cord-023095-4dannjjm 5581 19 ( ( -LRB- cord-023095-4dannjjm 5581 20 Heliox Heliox NNP cord-023095-4dannjjm 5581 21 ) ) -RRB- cord-023095-4dannjjm 5581 22 and and CC cord-023095-4dannjjm 5581 23 70:30 70:30 CD cord-023095-4dannjjm 5581 24 Nitrogen nitrogen NN cord-023095-4dannjjm 5581 25 : : : cord-023095-4dannjjm 5581 26 oxygen oxygen NN cord-023095-4dannjjm 5581 27 ( ( -LRB- cord-023095-4dannjjm 5581 28 Nitrox Nitrox NNP cord-023095-4dannjjm 5581 29 ) ) -RRB- cord-023095-4dannjjm 5581 30 in in IN cord-023095-4dannjjm 5581 31 a a DT cord-023095-4dannjjm 5581 32 randomized randomized JJ cord-023095-4dannjjm 5581 33 order order NN cord-023095-4dannjjm 5581 34 via via IN cord-023095-4dannjjm 5581 35 a a DT cord-023095-4dannjjm 5581 36 low low JJ cord-023095-4dannjjm 5581 37 dead dead JJ cord-023095-4dannjjm 5581 38 - - HYPH cord-023095-4dannjjm 5581 39 space space NN cord-023095-4dannjjm 5581 40 face face NN cord-023095-4dannjjm 5581 41 mask mask NN cord-023095-4dannjjm 5581 42 . . . cord-023095-4dannjjm 5582 1 Due due IN cord-023095-4dannjjm 5582 2 to to IN cord-023095-4dannjjm 5582 3 the the DT cord-023095-4dannjjm 5582 4 intrinsic intrinsic JJ cord-023095-4dannjjm 5582 5 gas gas NN cord-023095-4dannjjm 5582 6 properties property NNS cord-023095-4dannjjm 5582 7 , , , cord-023095-4dannjjm 5582 8 gas gas NN cord-023095-4dannjjm 5582 9 flow flow NN cord-023095-4dannjjm 5582 10 rates rate NNS cord-023095-4dannjjm 5582 11 and and CC cord-023095-4dannjjm 5582 12 volumes volume NNS cord-023095-4dannjjm 5582 13 were be VBD cord-023095-4dannjjm 5582 14 corrected correct VBN cord-023095-4dannjjm 5582 15 in in IN cord-023095-4dannjjm 5582 16 - - HYPH cord-023095-4dannjjm 5582 17 vitro vitro FW cord-023095-4dannjjm 5582 18 by by IN cord-023095-4dannjjm 5582 19 a a DT cord-023095-4dannjjm 5582 20 conversion conversion NN cord-023095-4dannjjm 5582 21 factor factor NN cord-023095-4dannjjm 5582 22 for for IN cord-023095-4dannjjm 5582 23 the the DT cord-023095-4dannjjm 5582 24 effect effect NN cord-023095-4dannjjm 5582 25 of of IN cord-023095-4dannjjm 5582 26 helium helium NN cord-023095-4dannjjm 5582 27 on on IN cord-023095-4dannjjm 5582 28 the the DT cord-023095-4dannjjm 5582 29 pneumotachograph pneumotachograph NN cord-023095-4dannjjm 5582 30 . . . cord-023095-4dannjjm 5583 1 Respiratory respiratory JJ cord-023095-4dannjjm 5583 2 rate rate NN cord-023095-4dannjjm 5583 3 , , , cord-023095-4dannjjm 5583 4 tidal tidal JJ cord-023095-4dannjjm 5583 5 volume volume NN cord-023095-4dannjjm 5583 6 ( ( -LRB- cord-023095-4dannjjm 5583 7 ml ml NN cord-023095-4dannjjm 5583 8 ) ) -RRB- cord-023095-4dannjjm 5583 9 , , , cord-023095-4dannjjm 5583 10 minute minute NN cord-023095-4dannjjm 5583 11 ventilation ventilation NN cord-023095-4dannjjm 5583 12 ( ( -LRB- cord-023095-4dannjjm 5583 13 L L NNP cord-023095-4dannjjm 5583 14 ) ) -RRB- cord-023095-4dannjjm 5583 15 , , , cord-023095-4dannjjm 5583 16 inspiratory inspiratory JJ cord-023095-4dannjjm 5583 17 time time NN cord-023095-4dannjjm 5583 18 ( ( -LRB- cord-023095-4dannjjm 5583 19 Ti Ti NNP cord-023095-4dannjjm 5583 20 ) ) -RRB- cord-023095-4dannjjm 5583 21 , , , cord-023095-4dannjjm 5583 22 expiratory expiratory JJ cord-023095-4dannjjm 5583 23 time time NN cord-023095-4dannjjm 5583 24 ( ( -LRB- cord-023095-4dannjjm 5583 25 Te Te NNP cord-023095-4dannjjm 5583 26 ) ) -RRB- cord-023095-4dannjjm 5583 27 , , , cord-023095-4dannjjm 5583 28 peak peak JJ cord-023095-4dannjjm 5583 29 inspiratory inspiratory JJ cord-023095-4dannjjm 5583 30 flow flow NN cord-023095-4dannjjm 5583 31 ( ( -LRB- cord-023095-4dannjjm 5583 32 PIF PIF NNP cord-023095-4dannjjm 5583 33 ) ) -RRB- cord-023095-4dannjjm 5583 34 and and CC cord-023095-4dannjjm 5583 35 peak peak NN cord-023095-4dannjjm 5583 36 expiratory expiratory JJ cord-023095-4dannjjm 5583 37 flow flow NN cord-023095-4dannjjm 5583 38 ( ( -LRB- cord-023095-4dannjjm 5583 39 PEF PEF NNP cord-023095-4dannjjm 5583 40 ) ) -RRB- cord-023095-4dannjjm 5583 41 were be VBD cord-023095-4dannjjm 5583 42 recorded record VBN cord-023095-4dannjjm 5583 43 while while IN cord-023095-4dannjjm 5583 44 breathing breathe VBG cord-023095-4dannjjm 5583 45 heliox heliox NNS cord-023095-4dannjjm 5583 46 or or CC cord-023095-4dannjjm 5583 47 nitrox nitrox NN cord-023095-4dannjjm 5583 48 . . . cord-023095-4dannjjm 5584 1 Values value NNS cord-023095-4dannjjm 5584 2 were be VBD cord-023095-4dannjjm 5584 3 compared compare VBN cord-023095-4dannjjm 5584 4 using use VBG cord-023095-4dannjjm 5584 5 a a DT cord-023095-4dannjjm 5584 6 paired pair VBN cord-023095-4dannjjm 5584 7 sample sample NN cord-023095-4dannjjm 5584 8 t t NN cord-023095-4dannjjm 5584 9 - - HYPH cord-023095-4dannjjm 5584 10 test test NN cord-023095-4dannjjm 5584 11 , , , cord-023095-4dannjjm 5584 12 with with IN cord-023095-4dannjjm 5584 13 P p NN cord-023095-4dannjjm 5584 14 o o NN cord-023095-4dannjjm 5584 15 0.05 0.05 CD cord-023095-4dannjjm 5584 16 considered consider VBN cord-023095-4dannjjm 5584 17 significant significant JJ cord-023095-4dannjjm 5584 18 . . . cord-023095-4dannjjm 5585 1 All all DT cord-023095-4dannjjm 5585 2 dogs dog NNS cord-023095-4dannjjm 5585 3 cooperated cooperate VBD cord-023095-4dannjjm 5585 4 with with IN cord-023095-4dannjjm 5585 5 testing testing NN cord-023095-4dannjjm 5585 6 . . . cord-023095-4dannjjm 5586 1 There there EX cord-023095-4dannjjm 5586 2 was be VBD cord-023095-4dannjjm 5586 3 no no DT cord-023095-4dannjjm 5586 4 significant significant JJ cord-023095-4dannjjm 5586 5 difference difference NN cord-023095-4dannjjm 5586 6 in in IN cord-023095-4dannjjm 5586 7 respiratory respiratory JJ cord-023095-4dannjjm 5586 8 rate rate NN cord-023095-4dannjjm 5586 9 , , , cord-023095-4dannjjm 5586 10 tidal tidal JJ cord-023095-4dannjjm 5586 11 volume volume NN cord-023095-4dannjjm 5586 12 , , , cord-023095-4dannjjm 5586 13 minute minute NN cord-023095-4dannjjm 5586 14 ventilation ventilation NN cord-023095-4dannjjm 5586 15 , , , cord-023095-4dannjjm 5586 16 inspiratory inspiratory JJ cord-023095-4dannjjm 5586 17 or or CC cord-023095-4dannjjm 5586 18 expiratory expiratory JJ cord-023095-4dannjjm 5586 19 times time NNS cord-023095-4dannjjm 5586 20 , , , cord-023095-4dannjjm 5586 21 or or CC cord-023095-4dannjjm 5586 22 peak peak JJ cord-023095-4dannjjm 5586 23 inspiratory inspiratory JJ cord-023095-4dannjjm 5586 24 flow flow NN cord-023095-4dannjjm 5586 25 . . . cord-023095-4dannjjm 5587 1 Peak Peak NNP cord-023095-4dannjjm 5587 2 expiratory expiratory JJ cord-023095-4dannjjm 5587 3 flow flow NN cord-023095-4dannjjm 5587 4 was be VBD cord-023095-4dannjjm 5587 5 significantly significantly RB cord-023095-4dannjjm 5587 6 higher high JJR cord-023095-4dannjjm 5587 7 ( ( -LRB- cord-023095-4dannjjm 5587 8 P p NN cord-023095-4dannjjm 5587 9 5 5 CD cord-023095-4dannjjm 5587 10 0.01 0.01 CD cord-023095-4dannjjm 5587 11 ) ) -RRB- cord-023095-4dannjjm 5587 12 while while IN cord-023095-4dannjjm 5587 13 breathing breathe VBG cord-023095-4dannjjm 5587 14 heliox heliox NNS cord-023095-4dannjjm 5587 15 than than IN cord-023095-4dannjjm 5587 16 when when WRB cord-023095-4dannjjm 5587 17 breathing breathe VBG cord-023095-4dannjjm 5587 18 nitrox nitrox NN cord-023095-4dannjjm 5587 19 in in IN cord-023095-4dannjjm 5587 20 brachycephalics brachycephalic NNS cord-023095-4dannjjm 5587 21 but but CC cord-023095-4dannjjm 5587 22 not not RB cord-023095-4dannjjm 5587 23 in in IN cord-023095-4dannjjm 5587 24 mesocephalics mesocephalic NNS cord-023095-4dannjjm 5587 25 ( ( -LRB- cord-023095-4dannjjm 5587 26 P p NN cord-023095-4dannjjm 5587 27 5 5 CD cord-023095-4dannjjm 5587 28 0.22 0.22 CD cord-023095-4dannjjm 5587 29 ) ) -RRB- cord-023095-4dannjjm 5587 30 . . . cord-023095-4dannjjm 5588 1 Heliox Heliox NNP cord-023095-4dannjjm 5588 2 is be VBZ cord-023095-4dannjjm 5588 3 well well RB cord-023095-4dannjjm 5588 4 - - HYPH cord-023095-4dannjjm 5588 5 tolerated tolerate VBN cord-023095-4dannjjm 5588 6 in in IN cord-023095-4dannjjm 5588 7 healthy healthy JJ cord-023095-4dannjjm 5588 8 dogs dog NNS cord-023095-4dannjjm 5588 9 and and CC cord-023095-4dannjjm 5588 10 results result NNS cord-023095-4dannjjm 5588 11 in in IN cord-023095-4dannjjm 5588 12 an an DT cord-023095-4dannjjm 5588 13 increased increase VBN cord-023095-4dannjjm 5588 14 expiratory expiratory JJ cord-023095-4dannjjm 5588 15 flow flow NN cord-023095-4dannjjm 5588 16 rate rate NN cord-023095-4dannjjm 5588 17 in in IN cord-023095-4dannjjm 5588 18 brachycephalic brachycephalic JJ cord-023095-4dannjjm 5588 19 dogs dog NNS cord-023095-4dannjjm 5588 20 . . . cord-023095-4dannjjm 5589 1 Further further JJ cord-023095-4dannjjm 5589 2 investigation investigation NN cord-023095-4dannjjm 5589 3 of of IN cord-023095-4dannjjm 5589 4 heliox heliox NNP cord-023095-4dannjjm 5589 5 is be VBZ cord-023095-4dannjjm 5589 6 warranted warrant VBN cord-023095-4dannjjm 5589 7 in in IN cord-023095-4dannjjm 5589 8 dogs dog NNS cord-023095-4dannjjm 5589 9 with with IN cord-023095-4dannjjm 5589 10 airway airway JJ cord-023095-4dannjjm 5589 11 obstruction obstruction NN cord-023095-4dannjjm 5589 12 . . . cord-023095-4dannjjm 5590 1 of of IN cord-023095-4dannjjm 5590 2 this this DT cord-023095-4dannjjm 5590 3 prospective prospective JJ cord-023095-4dannjjm 5590 4 multicentric multicentric JJ cord-023095-4dannjjm 5590 5 study study NN cord-023095-4dannjjm 5590 6 is be VBZ cord-023095-4dannjjm 5590 7 to to TO cord-023095-4dannjjm 5590 8 assess assess VB cord-023095-4dannjjm 5590 9 the the DT cord-023095-4dannjjm 5590 10 effects effect NNS cord-023095-4dannjjm 5590 11 that that WDT cord-023095-4dannjjm 5590 12 surgical surgical JJ cord-023095-4dannjjm 5590 13 correction correction NN cord-023095-4dannjjm 5590 14 has have VBZ cord-023095-4dannjjm 5590 15 on on IN cord-023095-4dannjjm 5590 16 the the DT cord-023095-4dannjjm 5590 17 severity severity NN cord-023095-4dannjjm 5590 18 of of IN cord-023095-4dannjjm 5590 19 clinical clinical JJ cord-023095-4dannjjm 5590 20 signs sign NNS cord-023095-4dannjjm 5590 21 and and CC cord-023095-4dannjjm 5590 22 levels level NNS cord-023095-4dannjjm 5590 23 of of IN cord-023095-4dannjjm 5590 24 acute acute JJ cord-023095-4dannjjm 5590 25 phase phase NN cord-023095-4dannjjm 5590 26 proteins protein NNS cord-023095-4dannjjm 5590 27 ( ( -LRB- cord-023095-4dannjjm 5590 28 C c NN cord-023095-4dannjjm 5590 29 - - HYPH cord-023095-4dannjjm 5590 30 reactive reactive JJ cord-023095-4dannjjm 5590 31 protein protein NN cord-023095-4dannjjm 5590 32 [ [ -LRB- cord-023095-4dannjjm 5590 33 CRP CRP NNP cord-023095-4dannjjm 5590 34 ] ] -RRB- cord-023095-4dannjjm 5590 35 , , , cord-023095-4dannjjm 5590 36 Haptoglobin Haptoglobin NNP cord-023095-4dannjjm 5590 37 [ [ -LRB- cord-023095-4dannjjm 5590 38 Hp Hp NNP cord-023095-4dannjjm 5590 39 ] ] -RRB- cord-023095-4dannjjm 5590 40 ) ) -RRB- cord-023095-4dannjjm 5590 41 and and CC cord-023095-4dannjjm 5590 42 cardiac cardiac JJ cord-023095-4dannjjm 5590 43 troponin troponin NN cord-023095-4dannjjm 5591 1 I -PRON- PRP cord-023095-4dannjjm 5591 2 ( ( -LRB- cord-023095-4dannjjm 5591 3 cTnI cTnI NNP cord-023095-4dannjjm 5591 4 ) ) -RRB- cord-023095-4dannjjm 5591 5 . . . cord-023095-4dannjjm 5592 1 Thirty thirty CD cord-023095-4dannjjm 5592 2 three three CD cord-023095-4dannjjm 5592 3 brachycephalic brachycephalic JJ cord-023095-4dannjjm 5592 4 dogs dog NNS cord-023095-4dannjjm 5592 5 with with IN cord-023095-4dannjjm 5592 6 BOAS boa NNS cord-023095-4dannjjm 5592 7 were be VBD cord-023095-4dannjjm 5592 8 included include VBN cord-023095-4dannjjm 5592 9 and and CC cord-023095-4dannjjm 5592 10 evaluated evaluate VBN cord-023095-4dannjjm 5592 11 before before RB cord-023095-4dannjjm 5592 12 and and CC cord-023095-4dannjjm 5592 13 , , , cord-023095-4dannjjm 5592 14 approximately approximately RB cord-023095-4dannjjm 5592 15 two two CD cord-023095-4dannjjm 5592 16 months month NNS cord-023095-4dannjjm 5592 17 , , , cord-023095-4dannjjm 5592 18 after after IN cord-023095-4dannjjm 5592 19 surgical surgical JJ cord-023095-4dannjjm 5592 20 correction correction NN cord-023095-4dannjjm 5592 21 . . . cord-023095-4dannjjm 5593 1 The the DT cord-023095-4dannjjm 5593 2 most most RBS cord-023095-4dannjjm 5593 3 common common JJ cord-023095-4dannjjm 5593 4 components component NNS cord-023095-4dannjjm 5593 5 of of IN cord-023095-4dannjjm 5593 6 BOAS boa NNS cord-023095-4dannjjm 5593 7 found find VBN cord-023095-4dannjjm 5593 8 were be VBD cord-023095-4dannjjm 5593 9 elongated elongated JJ cord-023095-4dannjjm 5593 10 soft soft JJ cord-023095-4dannjjm 5593 11 palate palate NN cord-023095-4dannjjm 5593 12 ( ( -LRB- cord-023095-4dannjjm 5593 13 33/33 33/33 CD cord-023095-4dannjjm 5593 14 ; ; : cord-023095-4dannjjm 5593 15 100 100 CD cord-023095-4dannjjm 5593 16 % % NN cord-023095-4dannjjm 5593 17 ) ) -RRB- cord-023095-4dannjjm 5593 18 , , , cord-023095-4dannjjm 5593 19 stenotic stenotic JJ cord-023095-4dannjjm 5593 20 nares nares NNP cord-023095-4dannjjm 5593 21 ( ( -LRB- cord-023095-4dannjjm 5593 22 31/33 31/33 CD cord-023095-4dannjjm 5593 23 ; ; : cord-023095-4dannjjm 5593 24 94 94 CD cord-023095-4dannjjm 5593 25 % % NN cord-023095-4dannjjm 5593 26 ) ) -RRB- cord-023095-4dannjjm 5593 27 and and CC cord-023095-4dannjjm 5593 28 everted everted JJ cord-023095-4dannjjm 5593 29 laryngeal laryngeal NN cord-023095-4dannjjm 5593 30 saccules saccule NNS cord-023095-4dannjjm 5593 31 ( ( -LRB- cord-023095-4dannjjm 5593 32 13/33 13/33 CD cord-023095-4dannjjm 5593 33 ; ; : cord-023095-4dannjjm 5593 34 39.4 39.4 CD cord-023095-4dannjjm 5593 35 % % NN cord-023095-4dannjjm 5593 36 ) ) -RRB- cord-023095-4dannjjm 5593 37 . . . cord-023095-4dannjjm 5594 1 Staphylectomy Staphylectomy NNP cord-023095-4dannjjm 5594 2 was be VBD cord-023095-4dannjjm 5594 3 performed perform VBN cord-023095-4dannjjm 5594 4 by by IN cord-023095-4dannjjm 5594 5 means mean NNS cord-023095-4dannjjm 5594 6 of of IN cord-023095-4dannjjm 5594 7 two two CD cord-023095-4dannjjm 5594 8 different different JJ cord-023095-4dannjjm 5594 9 surgical surgical JJ cord-023095-4dannjjm 5594 10 techniques technique NNS cord-023095-4dannjjm 5594 11 : : : cord-023095-4dannjjm 5594 12 laser laser NN cord-023095-4dannjjm 5594 13 ( ( -LRB- cord-023095-4dannjjm 5594 14 n n NN cord-023095-4dannjjm 5594 15 5 5 CD cord-023095-4dannjjm 5594 16 12 12 CD cord-023095-4dannjjm 5594 17 ) ) -RRB- cord-023095-4dannjjm 5594 18 or or CC cord-023095-4dannjjm 5594 19 electrical electrical JJ cord-023095-4dannjjm 5594 20 scalpel scalpel NN cord-023095-4dannjjm 5594 21 ( ( -LRB- cord-023095-4dannjjm 5594 22 n n NN cord-023095-4dannjjm 5594 23 5 5 CD cord-023095-4dannjjm 5594 24 21 21 CD cord-023095-4dannjjm 5594 25 ) ) -RRB- cord-023095-4dannjjm 5594 26 . . . cord-023095-4dannjjm 5595 1 There there EX cord-023095-4dannjjm 5595 2 were be VBD cord-023095-4dannjjm 5595 3 significant significant JJ cord-023095-4dannjjm 5595 4 differences difference NNS cord-023095-4dannjjm 5595 5 between between IN cord-023095-4dannjjm 5595 6 dogs dog NNS cord-023095-4dannjjm 5595 7 depending depend VBG cord-023095-4dannjjm 5595 8 on on IN cord-023095-4dannjjm 5595 9 the the DT cord-023095-4dannjjm 5595 10 surgical surgical JJ cord-023095-4dannjjm 5595 11 technique technique NN cord-023095-4dannjjm 5595 12 used use VBN cord-023095-4dannjjm 5595 13 , , , cord-023095-4dannjjm 5595 14 with with IN cord-023095-4dannjjm 5595 15 a a DT cord-023095-4dannjjm 5595 16 higher high JJR cord-023095-4dannjjm 5595 17 reduction reduction NN cord-023095-4dannjjm 5595 18 of of IN cord-023095-4dannjjm 5595 19 respiratory respiratory JJ cord-023095-4dannjjm 5595 20 signs sign NNS cord-023095-4dannjjm 5595 21 ( ( -LRB- cord-023095-4dannjjm 5595 22 p p NN cord-023095-4dannjjm 5595 23 o o NN cord-023095-4dannjjm 5595 24 0.002 0.002 CD cord-023095-4dannjjm 5595 25 ) ) -RRB- cord-023095-4dannjjm 5595 26 and and CC cord-023095-4dannjjm 5595 27 a a DT cord-023095-4dannjjm 5595 28 better well JJR cord-023095-4dannjjm 5595 29 postsurgical postsurgical JJ cord-023095-4dannjjm 5595 30 improvement improvement NN cord-023095-4dannjjm 5595 31 ( ( -LRB- cord-023095-4dannjjm 5595 32 p p NN cord-023095-4dannjjm 5595 33 o o NN cord-023095-4dannjjm 5595 34 0.015 0.015 CD cord-023095-4dannjjm 5595 35 ) ) -RRB- cord-023095-4dannjjm 5595 36 with with IN cord-023095-4dannjjm 5595 37 the the DT cord-023095-4dannjjm 5595 38 use use NN cord-023095-4dannjjm 5595 39 of of IN cord-023095-4dannjjm 5595 40 laser laser NN cord-023095-4dannjjm 5595 41 . . . cord-023095-4dannjjm 5596 1 The the DT cord-023095-4dannjjm 5596 2 levels level NNS cord-023095-4dannjjm 5596 3 of of IN cord-023095-4dannjjm 5596 4 CRP crp NN cord-023095-4dannjjm 5596 5 , , , cord-023095-4dannjjm 5596 6 Hp Hp NNP cord-023095-4dannjjm 5596 7 and and CC cord-023095-4dannjjm 5596 8 cTnI cTnI NNP cord-023095-4dannjjm 5596 9 were be VBD cord-023095-4dannjjm 5596 10 categorized categorize VBN cord-023095-4dannjjm 5596 11 into into IN cord-023095-4dannjjm 5596 12 normal normal JJ cord-023095-4dannjjm 5596 13 or or CC cord-023095-4dannjjm 5596 14 elevated elevated JJ cord-023095-4dannjjm 5596 15 . . . cord-023095-4dannjjm 5597 1 Before before IN cord-023095-4dannjjm 5597 2 surgical surgical JJ cord-023095-4dannjjm 5597 3 treatment treatment NN cord-023095-4dannjjm 5597 4 three three CD cord-023095-4dannjjm 5597 5 ( ( -LRB- cord-023095-4dannjjm 5597 6 9.1 9.1 CD cord-023095-4dannjjm 5597 7 % % NN cord-023095-4dannjjm 5597 8 ) ) -RRB- cord-023095-4dannjjm 5597 9 , , , cord-023095-4dannjjm 5597 10 six six CD cord-023095-4dannjjm 5597 11 ( ( -LRB- cord-023095-4dannjjm 5597 12 18.2 18.2 CD cord-023095-4dannjjm 5597 13 % % NN cord-023095-4dannjjm 5597 14 ) ) -RRB- cord-023095-4dannjjm 5597 15 and and CC cord-023095-4dannjjm 5597 16 thirteen thirteen CD cord-023095-4dannjjm 5597 17 ( ( -LRB- cord-023095-4dannjjm 5597 18 39.4 39.4 CD cord-023095-4dannjjm 5597 19 % % NN cord-023095-4dannjjm 5597 20 ) ) -RRB- cord-023095-4dannjjm 5597 21 dogs dog NNS cord-023095-4dannjjm 5597 22 had have VBD cord-023095-4dannjjm 5597 23 elevated elevate VBN cord-023095-4dannjjm 5597 24 values value NNS cord-023095-4dannjjm 5597 25 of of IN cord-023095-4dannjjm 5597 26 CRP crp NN cord-023095-4dannjjm 5597 27 , , , cord-023095-4dannjjm 5597 28 Hp Hp NNP cord-023095-4dannjjm 5597 29 and and CC cord-023095-4dannjjm 5597 30 cTnI cTnI NNP cord-023095-4dannjjm 5597 31 , , , cord-023095-4dannjjm 5597 32 respectively respectively RB cord-023095-4dannjjm 5597 33 . . . cord-023095-4dannjjm 5598 1 Two two CD cord-023095-4dannjjm 5598 2 months month NNS cord-023095-4dannjjm 5598 3 after after IN cord-023095-4dannjjm 5598 4 surgical surgical JJ cord-023095-4dannjjm 5598 5 correction correction NN cord-023095-4dannjjm 5598 6 , , , cord-023095-4dannjjm 5598 7 five five CD cord-023095-4dannjjm 5598 8 ( ( -LRB- cord-023095-4dannjjm 5598 9 15.1 15.1 CD cord-023095-4dannjjm 5598 10 % % NN cord-023095-4dannjjm 5598 11 ) ) -RRB- cord-023095-4dannjjm 5598 12 , , , cord-023095-4dannjjm 5598 13 eleven eleven CD cord-023095-4dannjjm 5598 14 ( ( -LRB- cord-023095-4dannjjm 5598 15 33.3 33.3 CD cord-023095-4dannjjm 5598 16 % % NN cord-023095-4dannjjm 5598 17 ) ) -RRB- cord-023095-4dannjjm 5598 18 and and CC cord-023095-4dannjjm 5598 19 fourteen fourteen CD cord-023095-4dannjjm 5598 20 ( ( -LRB- cord-023095-4dannjjm 5598 21 42.4 42.4 CD cord-023095-4dannjjm 5598 22 % % NN cord-023095-4dannjjm 5598 23 ) ) -RRB- cord-023095-4dannjjm 5598 24 dogs dog NNS cord-023095-4dannjjm 5598 25 had have VBD cord-023095-4dannjjm 5598 26 elevated elevate VBN cord-023095-4dannjjm 5598 27 values value NNS cord-023095-4dannjjm 5598 28 of of IN cord-023095-4dannjjm 5598 29 CRP crp NN cord-023095-4dannjjm 5598 30 , , , cord-023095-4dannjjm 5598 31 Hp Hp NNP cord-023095-4dannjjm 5598 32 and and CC cord-023095-4dannjjm 5598 33 cTnI cTnI NNP cord-023095-4dannjjm 5598 34 , , , cord-023095-4dannjjm 5598 35 respectively respectively RB cord-023095-4dannjjm 5598 36 . . . cord-023095-4dannjjm 5599 1 There there EX cord-023095-4dannjjm 5599 2 were be VBD cord-023095-4dannjjm 5599 3 no no DT cord-023095-4dannjjm 5599 4 statistical statistical JJ cord-023095-4dannjjm 5599 5 differences difference NNS cord-023095-4dannjjm 5599 6 between between IN cord-023095-4dannjjm 5599 7 values value NNS cord-023095-4dannjjm 5599 8 of of IN cord-023095-4dannjjm 5599 9 CRP crp NN cord-023095-4dannjjm 5599 10 and and CC cord-023095-4dannjjm 5599 11 cTnI cTnI VBN cord-023095-4dannjjm 5599 12 before before IN cord-023095-4dannjjm 5599 13 and and CC cord-023095-4dannjjm 5599 14 after after IN cord-023095-4dannjjm 5599 15 surgical surgical JJ cord-023095-4dannjjm 5599 16 correction correction NN cord-023095-4dannjjm 5599 17 but but CC cord-023095-4dannjjm 5599 18 the the DT cord-023095-4dannjjm 5599 19 levels level NNS cord-023095-4dannjjm 5599 20 of of IN cord-023095-4dannjjm 5599 21 Hp Hp NNP cord-023095-4dannjjm 5599 22 increased increase VBD cord-023095-4dannjjm 5599 23 significantly significantly RB cord-023095-4dannjjm 5599 24 after after IN cord-023095-4dannjjm 5599 25 surgical surgical JJ cord-023095-4dannjjm 5599 26 treatment treatment NN cord-023095-4dannjjm 5599 27 ( ( -LRB- cord-023095-4dannjjm 5599 28 p p NN cord-023095-4dannjjm 5599 29 o o NN cord-023095-4dannjjm 5599 30 0.008 0.008 CD cord-023095-4dannjjm 5599 31 ) ) -RRB- cord-023095-4dannjjm 5599 32 , , , cord-023095-4dannjjm 5599 33 probably probably RB cord-023095-4dannjjm 5599 34 due due JJ cord-023095-4dannjjm 5599 35 to to IN cord-023095-4dannjjm 5599 36 postsurgical postsurgical JJ cord-023095-4dannjjm 5599 37 treatment treatment NN cord-023095-4dannjjm 5599 38 with with IN cord-023095-4dannjjm 5599 39 corticosteroids corticosteroid NNS cord-023095-4dannjjm 5599 40 . . . cord-023095-4dannjjm 5600 1 As as IN cord-023095-4dannjjm 5600 2 previously previously RB cord-023095-4dannjjm 5600 3 suggested suggest VBN cord-023095-4dannjjm 5600 4 by by IN cord-023095-4dannjjm 5600 5 others other NNS cord-023095-4dannjjm 5600 6 , , , cord-023095-4dannjjm 5600 7 there there EX cord-023095-4dannjjm 5600 8 was be VBD cord-023095-4dannjjm 5600 9 a a DT cord-023095-4dannjjm 5600 10 statistically statistically RB cord-023095-4dannjjm 5600 11 significant significant JJ cord-023095-4dannjjm 5600 12 reduction reduction NN cord-023095-4dannjjm 5600 13 of of IN cord-023095-4dannjjm 5600 14 respiratory respiratory JJ cord-023095-4dannjjm 5600 15 and and CC cord-023095-4dannjjm 5600 16 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 5600 17 signs sign NNS cord-023095-4dannjjm 5600 18 in in IN cord-023095-4dannjjm 5600 19 dogs dog NNS cord-023095-4dannjjm 5600 20 with with IN cord-023095-4dannjjm 5600 21 BOAS boa NNS cord-023095-4dannjjm 5600 22 submitted submit VBN cord-023095-4dannjjm 5600 23 to to IN cord-023095-4dannjjm 5600 24 surgical surgical JJ cord-023095-4dannjjm 5600 25 correction correction NN cord-023095-4dannjjm 5600 26 ( ( -LRB- cord-023095-4dannjjm 5600 27 p p NN cord-023095-4dannjjm 5600 28 o o NN cord-023095-4dannjjm 5600 29 0,001 0,001 CD cord-023095-4dannjjm 5600 30 ) ) -RRB- cord-023095-4dannjjm 5600 31 . . . cord-023095-4dannjjm 5601 1 According accord VBG cord-023095-4dannjjm 5601 2 to to IN cord-023095-4dannjjm 5601 3 the the DT cord-023095-4dannjjm 5601 4 results result NNS cord-023095-4dannjjm 5601 5 obtained obtain VBN cord-023095-4dannjjm 5601 6 in in IN cord-023095-4dannjjm 5601 7 the the DT cord-023095-4dannjjm 5601 8 present present JJ cord-023095-4dannjjm 5601 9 study study NN cord-023095-4dannjjm 5601 10 , , , cord-023095-4dannjjm 5601 11 the the DT cord-023095-4dannjjm 5601 12 determination determination NN cord-023095-4dannjjm 5601 13 of of IN cord-023095-4dannjjm 5601 14 CRP CRP NNP cord-023095-4dannjjm 5601 15 , , , cord-023095-4dannjjm 5601 16 Hp Hp NNP cord-023095-4dannjjm 5601 17 and and CC cord-023095-4dannjjm 5601 18 cTnI cTnI VBD cord-023095-4dannjjm 5601 19 before before RB cord-023095-4dannjjm 5601 20 and and CC cord-023095-4dannjjm 5601 21 two two CD cord-023095-4dannjjm 5601 22 months month NNS cord-023095-4dannjjm 5601 23 after after IN cord-023095-4dannjjm 5601 24 surgical surgical JJ cord-023095-4dannjjm 5601 25 treatment treatment NN cord-023095-4dannjjm 5601 26 do do VBP cord-023095-4dannjjm 5601 27 not not RB cord-023095-4dannjjm 5601 28 have have VB cord-023095-4dannjjm 5601 29 a a DT cord-023095-4dannjjm 5601 30 prognostic prognostic JJ cord-023095-4dannjjm 5601 31 value value NN cord-023095-4dannjjm 5601 32 in in IN cord-023095-4dannjjm 5601 33 dogs dog NNS cord-023095-4dannjjm 5601 34 with with IN cord-023095-4dannjjm 5601 35 BOAS boa NNS cord-023095-4dannjjm 5601 36 . . . cord-023095-4dannjjm 5602 1 Even even RB cord-023095-4dannjjm 5602 2 though though RB cord-023095-4dannjjm 5602 3 , , , cord-023095-4dannjjm 5602 4 near near IN cord-023095-4dannjjm 5602 5 half half NN cord-023095-4dannjjm 5602 6 of of IN cord-023095-4dannjjm 5602 7 the the DT cord-023095-4dannjjm 5602 8 dogs dog NNS cord-023095-4dannjjm 5602 9 studied study VBD cord-023095-4dannjjm 5602 10 had have VBD cord-023095-4dannjjm 5602 11 elevated elevate VBN cord-023095-4dannjjm 5602 12 levels level NNS cord-023095-4dannjjm 5602 13 of of IN cord-023095-4dannjjm 5602 14 cTnI cTnI NNP cord-023095-4dannjjm 5602 15 ( ( -LRB- cord-023095-4dannjjm 5602 16 39.4 39.4 CD cord-023095-4dannjjm 5602 17 % % NN cord-023095-4dannjjm 5602 18 ) ) -RRB- cord-023095-4dannjjm 5602 19 that that WDT cord-023095-4dannjjm 5602 20 persisted persist VBD cord-023095-4dannjjm 5602 21 after after IN cord-023095-4dannjjm 5602 22 surgical surgical JJ cord-023095-4dannjjm 5602 23 treatment treatment NN cord-023095-4dannjjm 5602 24 ( ( -LRB- cord-023095-4dannjjm 5602 25 42.4 42.4 CD cord-023095-4dannjjm 5602 26 % % NN cord-023095-4dannjjm 5602 27 ) ) -RRB- cord-023095-4dannjjm 5602 28 , , , cord-023095-4dannjjm 5602 29 suggesting suggest VBG cord-023095-4dannjjm 5602 30 some some DT cord-023095-4dannjjm 5602 31 degree degree NN cord-023095-4dannjjm 5602 32 of of IN cord-023095-4dannjjm 5602 33 myocardial myocardial JJ cord-023095-4dannjjm 5602 34 damage damage NN cord-023095-4dannjjm 5602 35 is be VBZ cord-023095-4dannjjm 5602 36 present present JJ cord-023095-4dannjjm 5602 37 . . . cord-023095-4dannjjm 5603 1 Further further JJ cord-023095-4dannjjm 5603 2 studies study NNS cord-023095-4dannjjm 5603 3 are be VBP cord-023095-4dannjjm 5603 4 needed need VBN cord-023095-4dannjjm 5603 5 considering consider VBG cord-023095-4dannjjm 5603 6 the the DT cord-023095-4dannjjm 5603 7 influence influence NN cord-023095-4dannjjm 5603 8 of of IN cord-023095-4dannjjm 5603 9 breed breed NN cord-023095-4dannjjm 5603 10 and and CC cord-023095-4dannjjm 5603 11 age age NN cord-023095-4dannjjm 5603 12 . . . cord-023095-4dannjjm 5604 1 To to IN cord-023095-4dannjjm 5604 2 the the DT cord-023095-4dannjjm 5604 3 authors author NNS cord-023095-4dannjjm 5604 4 ' ' POS cord-023095-4dannjjm 5604 5 knowledge knowledge NN cord-023095-4dannjjm 5604 6 , , , cord-023095-4dannjjm 5604 7 this this DT cord-023095-4dannjjm 5604 8 is be VBZ cord-023095-4dannjjm 5604 9 the the DT cord-023095-4dannjjm 5604 10 first first JJ cord-023095-4dannjjm 5604 11 description description NN cord-023095-4dannjjm 5604 12 of of IN cord-023095-4dannjjm 5604 13 CRP CRP NNP cord-023095-4dannjjm 5604 14 , , , cord-023095-4dannjjm 5604 15 Hp Hp NNP cord-023095-4dannjjm 5604 16 and and CC cord-023095-4dannjjm 5604 17 cTnI ctni JJ cord-023095-4dannjjm 5604 18 determination determination NN cord-023095-4dannjjm 5604 19 in in IN cord-023095-4dannjjm 5604 20 dogs dog NNS cord-023095-4dannjjm 5604 21 with with IN cord-023095-4dannjjm 5604 22 BOAS boa NNS cord-023095-4dannjjm 5604 23 . . . cord-023095-4dannjjm 5605 1 Overweight overweight JJ cord-023095-4dannjjm 5605 2 and and CC cord-023095-4dannjjm 5605 3 obesity obesity NN cord-023095-4dannjjm 5605 4 are be VBP cord-023095-4dannjjm 5605 5 common common JJ cord-023095-4dannjjm 5605 6 conditions condition NNS cord-023095-4dannjjm 5605 7 that that WDT cord-023095-4dannjjm 5605 8 lead lead VBP cord-023095-4dannjjm 5605 9 to to IN cord-023095-4dannjjm 5605 10 alterations alteration NNS cord-023095-4dannjjm 5605 11 in in IN cord-023095-4dannjjm 5605 12 respiratory respiratory JJ cord-023095-4dannjjm 5605 13 mechanics mechanic NNS cord-023095-4dannjjm 5605 14 , , , cord-023095-4dannjjm 5605 15 airway airway NN cord-023095-4dannjjm 5605 16 resistance resistance NN cord-023095-4dannjjm 5605 17 , , , cord-023095-4dannjjm 5605 18 pattern pattern NN cord-023095-4dannjjm 5605 19 of of IN cord-023095-4dannjjm 5605 20 breathing breathing NN cord-023095-4dannjjm 5605 21 and and CC cord-023095-4dannjjm 5605 22 gas gas NN cord-023095-4dannjjm 5605 23 exchange exchange NN cord-023095-4dannjjm 5605 24 in in IN cord-023095-4dannjjm 5605 25 humans human NNS cord-023095-4dannjjm 5605 26 . . . cord-023095-4dannjjm 5606 1 The the DT cord-023095-4dannjjm 5606 2 objective objective NN cord-023095-4dannjjm 5606 3 of of IN cord-023095-4dannjjm 5606 4 the the DT cord-023095-4dannjjm 5606 5 present present JJ cord-023095-4dannjjm 5606 6 study study NN cord-023095-4dannjjm 5606 7 was be VBD cord-023095-4dannjjm 5606 8 to to TO cord-023095-4dannjjm 5606 9 investigate investigate VB cord-023095-4dannjjm 5606 10 if if IN cord-023095-4dannjjm 5606 11 there there EX cord-023095-4dannjjm 5606 12 are be VBP cord-023095-4dannjjm 5606 13 significant significant JJ cord-023095-4dannjjm 5606 14 differences difference NNS cord-023095-4dannjjm 5606 15 on on IN cord-023095-4dannjjm 5606 16 respiratory respiratory JJ cord-023095-4dannjjm 5606 17 parameters parameter NNS cord-023095-4dannjjm 5606 18 and and CC cord-023095-4dannjjm 5606 19 arterial arterial JJ cord-023095-4dannjjm 5606 20 gas gas NN cord-023095-4dannjjm 5606 21 analysis analysis NN cord-023095-4dannjjm 5606 22 of of IN cord-023095-4dannjjm 5606 23 obese obese JJ cord-023095-4dannjjm 5606 24 and and CC cord-023095-4dannjjm 5606 25 overweight overweight JJ cord-023095-4dannjjm 5606 26 cats cat NNS cord-023095-4dannjjm 5606 27 , , , cord-023095-4dannjjm 5606 28 in in IN cord-023095-4dannjjm 5606 29 conscious conscious JJ cord-023095-4dannjjm 5606 30 state state NN cord-023095-4dannjjm 5606 31 and and CC cord-023095-4dannjjm 5606 32 under under IN cord-023095-4dannjjm 5606 33 general general JJ cord-023095-4dannjjm 5606 34 anesthesia anesthesia NN cord-023095-4dannjjm 5606 35 . . . cord-023095-4dannjjm 5607 1 Twenty twenty CD cord-023095-4dannjjm 5607 2 nine nine CD cord-023095-4dannjjm 5607 3 adult adult NN cord-023095-4dannjjm 5607 4 cats cat NNS cord-023095-4dannjjm 5607 5 were be VBD cord-023095-4dannjjm 5607 6 arranged arrange VBN cord-023095-4dannjjm 5607 7 in in IN cord-023095-4dannjjm 5607 8 three three CD cord-023095-4dannjjm 5607 9 groups group NNS cord-023095-4dannjjm 5607 10 : : : cord-023095-4dannjjm 5607 11 obese obese JJ cord-023095-4dannjjm 5607 12 ( ( -LRB- cord-023095-4dannjjm 5607 13 n n NN cord-023095-4dannjjm 5607 14 5 5 CD cord-023095-4dannjjm 5607 15 15 15 CD cord-023095-4dannjjm 5607 16 ) ) -RRB- cord-023095-4dannjjm 5607 17 , , , cord-023095-4dannjjm 5607 18 overweight overweight JJ cord-023095-4dannjjm 5607 19 ( ( -LRB- cord-023095-4dannjjm 5607 20 n n NN cord-023095-4dannjjm 5607 21 5 5 CD cord-023095-4dannjjm 5607 22 7 7 CD cord-023095-4dannjjm 5607 23 ) ) -RRB- cord-023095-4dannjjm 5607 24 and and CC cord-023095-4dannjjm 5607 25 with with IN cord-023095-4dannjjm 5607 26 ideal ideal JJ cord-023095-4dannjjm 5607 27 body body NN cord-023095-4dannjjm 5607 28 score score NN cord-023095-4dannjjm 5607 29 index index NN cord-023095-4dannjjm 5607 30 ( ( -LRB- cord-023095-4dannjjm 5607 31 BSI BSI NNP cord-023095-4dannjjm 5607 32 ) ) -RRB- cord-023095-4dannjjm 5607 33 ( ( -LRB- cord-023095-4dannjjm 5607 34 n n NN cord-023095-4dannjjm 5607 35 5 5 CD cord-023095-4dannjjm 5607 36 7 7 CD cord-023095-4dannjjm 5607 37 ) ) -RRB- cord-023095-4dannjjm 5607 38 . . . cord-023095-4dannjjm 5608 1 Mean mean JJ cord-023095-4dannjjm 5608 2 of of IN cord-023095-4dannjjm 5608 3 BSI BSI NNP cord-023095-4dannjjm 5608 4 in in IN cord-023095-4dannjjm 5608 5 the the DT cord-023095-4dannjjm 5608 6 groups group NNS cord-023095-4dannjjm 5608 7 were be VBD cord-023095-4dannjjm 5608 8 : : : cord-023095-4dannjjm 5608 9 8,8 8,8 CD cord-023095-4dannjjm 5608 10 ( ( -LRB- cord-023095-4dannjjm 5608 11 obese obese JJ cord-023095-4dannjjm 5608 12 ) ) -RRB- cord-023095-4dannjjm 5608 13 , , . cord-023095-4dannjjm 5609 1 6,3 6,3 CD cord-023095-4dannjjm 5609 2 ( ( -LRB- cord-023095-4dannjjm 5609 3 overweight overweight NN cord-023095-4dannjjm 5609 4 ) ) -RRB- cord-023095-4dannjjm 5609 5 and and CC cord-023095-4dannjjm 5609 6 4,9 4,9 LS cord-023095-4dannjjm 5609 7 ( ( -LRB- cord-023095-4dannjjm 5609 8 ideal ideal JJ cord-023095-4dannjjm 5609 9 BSI BSI NNP cord-023095-4dannjjm 5609 10 ) ) -RRB- cord-023095-4dannjjm 5609 11 . . . cord-023095-4dannjjm 5610 1 Cats cat NNS cord-023095-4dannjjm 5610 2 did do VBD cord-023095-4dannjjm 5610 3 not not RB cord-023095-4dannjjm 5610 4 had have VBD cord-023095-4dannjjm 5610 5 respiratory respiratory JJ cord-023095-4dannjjm 5610 6 , , , cord-023095-4dannjjm 5610 7 cardiac cardiac JJ cord-023095-4dannjjm 5610 8 or or CC cord-023095-4dannjjm 5610 9 others other NNS cord-023095-4dannjjm 5610 10 systemic systemic JJ cord-023095-4dannjjm 5610 11 diseases disease NNS cord-023095-4dannjjm 5610 12 . . . cord-023095-4dannjjm 5611 1 The the DT cord-023095-4dannjjm 5611 2 respiratory respiratory JJ cord-023095-4dannjjm 5611 3 parameters parameter NNS cord-023095-4dannjjm 5611 4 were be VBD cord-023095-4dannjjm 5611 5 evaluated evaluate VBN cord-023095-4dannjjm 5611 6 with with IN cord-023095-4dannjjm 5611 7 a a DT cord-023095-4dannjjm 5611 8 ventilometer ventilometer JJ cord-023095-4dannjjm 5611 9 equipment equipment NN cord-023095-4dannjjm 5611 10 coupled couple VBN cord-023095-4dannjjm 5611 11 to to IN cord-023095-4dannjjm 5611 12 facemasks facemask NNS cord-023095-4dannjjm 5611 13 in in IN cord-023095-4dannjjm 5611 14 conscious conscious JJ cord-023095-4dannjjm 5611 15 cats cat NNS cord-023095-4dannjjm 5611 16 and and CC cord-023095-4dannjjm 5611 17 directly directly RB cord-023095-4dannjjm 5611 18 to to IN cord-023095-4dannjjm 5611 19 the the DT cord-023095-4dannjjm 5611 20 endotracheal endotracheal NN cord-023095-4dannjjm 5611 21 tube tube NN cord-023095-4dannjjm 5611 22 in in IN cord-023095-4dannjjm 5611 23 anesthetized anesthetize VBN cord-023095-4dannjjm 5611 24 cats cat NNS cord-023095-4dannjjm 5611 25 under under IN cord-023095-4dannjjm 5611 26 spontaneous spontaneous JJ cord-023095-4dannjjm 5611 27 respiration respiration NN cord-023095-4dannjjm 5611 28 . . . cord-023095-4dannjjm 5612 1 The the DT cord-023095-4dannjjm 5612 2 anesthesia anesthesia NN cord-023095-4dannjjm 5612 3 was be VBD cord-023095-4dannjjm 5612 4 performed perform VBN cord-023095-4dannjjm 5612 5 with with IN cord-023095-4dannjjm 5612 6 propofol propofol NN cord-023095-4dannjjm 5612 7 ( ( -LRB- cord-023095-4dannjjm 5612 8 3 3 CD cord-023095-4dannjjm 5612 9 AE AE NNP cord-023095-4dannjjm 5612 10 1,2 1,2 CD cord-023095-4dannjjm 5612 11 ml ml NN cord-023095-4dannjjm 5612 12 / / SYM cord-023095-4dannjjm 5612 13 kg kg NNP cord-023095-4dannjjm 5612 14 ) ) -RRB- cord-023095-4dannjjm 5612 15 and and CC cord-023095-4dannjjm 5612 16 the the DT cord-023095-4dannjjm 5612 17 cats cat NNS cord-023095-4dannjjm 5612 18 were be VBD cord-023095-4dannjjm 5612 19 maintained maintain VBN cord-023095-4dannjjm 5612 20 in in IN cord-023095-4dannjjm 5612 21 the the DT cord-023095-4dannjjm 5612 22 same same JJ cord-023095-4dannjjm 5612 23 anesthetic anesthetic JJ cord-023095-4dannjjm 5612 24 plan plan NN cord-023095-4dannjjm 5612 25 . . . cord-023095-4dannjjm 5613 1 The the DT cord-023095-4dannjjm 5613 2 three three CD cord-023095-4dannjjm 5613 3 groups group NNS cord-023095-4dannjjm 5613 4 were be VBD cord-023095-4dannjjm 5613 5 compared compare VBN cord-023095-4dannjjm 5613 6 by by IN cord-023095-4dannjjm 5613 7 analysis analysis NN cord-023095-4dannjjm 5613 8 of of IN cord-023095-4dannjjm 5613 9 variance variance NN cord-023095-4dannjjm 5613 10 followed follow VBN cord-023095-4dannjjm 5613 11 by by IN cord-023095-4dannjjm 5613 12 Tukey Tukey NNP cord-023095-4dannjjm 5613 13 's 's POS cord-023095-4dannjjm 5613 14 test test NN cord-023095-4dannjjm 5613 15 and and CC cord-023095-4dannjjm 5613 16 conscious conscious JJ cord-023095-4dannjjm 5613 17 and and CC cord-023095-4dannjjm 5613 18 anesthetized anesthetized JJ cord-023095-4dannjjm 5613 19 cats cat NNS cord-023095-4dannjjm 5613 20 were be VBD cord-023095-4dannjjm 5613 21 compared compare VBN cord-023095-4dannjjm 5613 22 by by IN cord-023095-4dannjjm 5613 23 Student Student NNP cord-023095-4dannjjm 5613 24 's 's POS cord-023095-4dannjjm 5613 25 T t NN cord-023095-4dannjjm 5613 26 test test NN cord-023095-4dannjjm 5613 27 , , , cord-023095-4dannjjm 5613 28 with with IN cord-023095-4dannjjm 5613 29 a a DT cord-023095-4dannjjm 5613 30 5 5 CD cord-023095-4dannjjm 5613 31 % % NN cord-023095-4dannjjm 5613 32 significance significance NN cord-023095-4dannjjm 5613 33 level level NN cord-023095-4dannjjm 5613 34 . . . cord-023095-4dannjjm 5614 1 There there EX cord-023095-4dannjjm 5614 2 were be VBD cord-023095-4dannjjm 5614 3 not not RB cord-023095-4dannjjm 5614 4 observed observe VBN cord-023095-4dannjjm 5614 5 differences difference NNS cord-023095-4dannjjm 5614 6 on on IN cord-023095-4dannjjm 5614 7 the the DT cord-023095-4dannjjm 5614 8 respiratory respiratory JJ cord-023095-4dannjjm 5614 9 parameters parameter NNS cord-023095-4dannjjm 5614 10 evaluated evaluate VBN cord-023095-4dannjjm 5614 11 on on IN cord-023095-4dannjjm 5614 12 ventilometry ventilometry NN cord-023095-4dannjjm 5614 13 ( ( -LRB- cord-023095-4dannjjm 5614 14 tidal tidal JJ cord-023095-4dannjjm 5614 15 volume volume NN cord-023095-4dannjjm 5614 16 , , , cord-023095-4dannjjm 5614 17 expiratory expiratory JJ cord-023095-4dannjjm 5614 18 and and CC cord-023095-4dannjjm 5614 19 inspiratory inspiratory JJ cord-023095-4dannjjm 5614 20 times time NNS cord-023095-4dannjjm 5614 21 and and CC cord-023095-4dannjjm 5614 22 peak peak NN cord-023095-4dannjjm 5614 23 pressures pressure NNS cord-023095-4dannjjm 5614 24 , , , cord-023095-4dannjjm 5614 25 respiratory respiratory JJ cord-023095-4dannjjm 5614 26 rate rate NN cord-023095-4dannjjm 5614 27 and and CC cord-023095-4dannjjm 5614 28 partial partial JJ cord-023095-4dannjjm 5614 29 pressure pressure NN cord-023095-4dannjjm 5614 30 of of IN cord-023095-4dannjjm 5614 31 end end NN cord-023095-4dannjjm 5614 32 tidal tidal JJ cord-023095-4dannjjm 5614 33 CO co NN cord-023095-4dannjjm 5614 34 2 2 CD cord-023095-4dannjjm 5615 1 ( ( -LRB- cord-023095-4dannjjm 5615 2 PETCO PETCO NNP cord-023095-4dannjjm 5615 3 2 2 CD cord-023095-4dannjjm 5615 4 ) ) -RRB- cord-023095-4dannjjm 5615 5 ) ) -RRB- cord-023095-4dannjjm 5616 1 and and CC cord-023095-4dannjjm 5616 2 on on IN cord-023095-4dannjjm 5616 3 arterial arterial JJ cord-023095-4dannjjm 5616 4 gas gas NN cord-023095-4dannjjm 5616 5 parameters parameter NNS cord-023095-4dannjjm 5616 6 ( ( -LRB- cord-023095-4dannjjm 5616 7 PaO pao JJ cord-023095-4dannjjm 5616 8 2 2 CD cord-023095-4dannjjm 5616 9 e e NN cord-023095-4dannjjm 5616 10 PaCO paco NN cord-023095-4dannjjm 5616 11 2 2 CD cord-023095-4dannjjm 5616 12 ) ) -RRB- cord-023095-4dannjjm 5616 13 in in IN cord-023095-4dannjjm 5616 14 the the DT cord-023095-4dannjjm 5616 15 three three CD cord-023095-4dannjjm 5616 16 groups group NNS cord-023095-4dannjjm 5616 17 . . . cord-023095-4dannjjm 5617 1 The the DT cord-023095-4dannjjm 5617 2 PaO pao JJ cord-023095-4dannjjm 5617 3 2 2 CD cord-023095-4dannjjm 5617 4 of of IN cord-023095-4dannjjm 5617 5 cats cat NNS cord-023095-4dannjjm 5617 6 with with IN cord-023095-4dannjjm 5617 7 ideal ideal JJ cord-023095-4dannjjm 5617 8 BSI BSI NNP cord-023095-4dannjjm 5617 9 was be VBD cord-023095-4dannjjm 5617 10 88,1 88,1 CD cord-023095-4dannjjm 5617 11 AE AE NNP cord-023095-4dannjjm 5617 12 13,5 13,5 CD cord-023095-4dannjjm 5617 13 mmHg mmHg NNS cord-023095-4dannjjm 5617 14 , , , cord-023095-4dannjjm 5617 15 although although IN cord-023095-4dannjjm 5617 16 was be VBD cord-023095-4dannjjm 5617 17 not not RB cord-023095-4dannjjm 5617 18 significantly significantly RB cord-023095-4dannjjm 5617 19 different different JJ cord-023095-4dannjjm 5618 1 ( ( -LRB- cord-023095-4dannjjm 5618 2 p p NN cord-023095-4dannjjm 5618 3 5 5 CD cord-023095-4dannjjm 5618 4 0,06 0,06 CD cord-023095-4dannjjm 5618 5 ) ) -RRB- cord-023095-4dannjjm 5618 6 from from IN cord-023095-4dannjjm 5618 7 overweight overweight NN cord-023095-4dannjjm 5618 8 ( ( -LRB- cord-023095-4dannjjm 5618 9 72,0 72,0 CD cord-023095-4dannjjm 5618 10 AE AE NNP cord-023095-4dannjjm 5618 11 11,9 11,9 CD cord-023095-4dannjjm 5618 12 mmHg mmHg NNPS cord-023095-4dannjjm 5618 13 ) ) -RRB- cord-023095-4dannjjm 5618 14 and and CC cord-023095-4dannjjm 5618 15 obese obese JJ cord-023095-4dannjjm 5618 16 cats cat NNS cord-023095-4dannjjm 5619 1 ( ( -LRB- cord-023095-4dannjjm 5619 2 72,6 72,6 DT cord-023095-4dannjjm 5619 3 AE AE NNP cord-023095-4dannjjm 5619 4 14,6 14,6 CD cord-023095-4dannjjm 5619 5 mmHg mmHg NNS cord-023095-4dannjjm 5619 6 ) ) -RRB- cord-023095-4dannjjm 5619 7 . . . cord-023095-4dannjjm 5620 1 Comparison comparison NN cord-023095-4dannjjm 5620 2 of of IN cord-023095-4dannjjm 5620 3 anesthetized anesthetize VBN cord-023095-4dannjjm 5620 4 to to IN cord-023095-4dannjjm 5620 5 conscious conscious JJ cord-023095-4dannjjm 5620 6 cats cat NNS cord-023095-4dannjjm 5620 7 , , , cord-023095-4dannjjm 5620 8 it -PRON- PRP cord-023095-4dannjjm 5620 9 was be VBD cord-023095-4dannjjm 5620 10 detected detect VBN cord-023095-4dannjjm 5620 11 decreases decrease NNS cord-023095-4dannjjm 5620 12 in in IN cord-023095-4dannjjm 5620 13 tidal tidal JJ cord-023095-4dannjjm 5620 14 volume volume NN cord-023095-4dannjjm 5620 15 , , , cord-023095-4dannjjm 5620 16 expiratory expiratory JJ cord-023095-4dannjjm 5620 17 and and CC cord-023095-4dannjjm 5620 18 inspiratory inspiratory JJ cord-023095-4dannjjm 5620 19 times time NNS cord-023095-4dannjjm 5620 20 and and CC cord-023095-4dannjjm 5620 21 peak peak NN cord-023095-4dannjjm 5620 22 pressures pressure NNS cord-023095-4dannjjm 5620 23 and and CC cord-023095-4dannjjm 5620 24 increase increase VBP cord-023095-4dannjjm 5620 25 in in IN cord-023095-4dannjjm 5620 26 PETCO PETCO NNP cord-023095-4dannjjm 5620 27 2 2 CD cord-023095-4dannjjm 5620 28 in in IN cord-023095-4dannjjm 5620 29 respiratory respiratory JJ cord-023095-4dannjjm 5620 30 rate rate NN cord-023095-4dannjjm 5620 31 in in IN cord-023095-4dannjjm 5620 32 the the DT cord-023095-4dannjjm 5620 33 anesthetized anesthetize VBN cord-023095-4dannjjm 5620 34 cats cat NNS cord-023095-4dannjjm 5620 35 . . . cord-023095-4dannjjm 5621 1 Only only RB cord-023095-4dannjjm 5621 2 PETCO PETCO NNP cord-023095-4dannjjm 5621 3 2 2 CD cord-023095-4dannjjm 5621 4 , , , cord-023095-4dannjjm 5621 5 inspiratory inspiratory JJ cord-023095-4dannjjm 5621 6 time time NN cord-023095-4dannjjm 5621 7 and and CC cord-023095-4dannjjm 5621 8 respiratory respiratory JJ cord-023095-4dannjjm 5621 9 rate rate NN cord-023095-4dannjjm 5621 10 in in IN cord-023095-4dannjjm 5621 11 overweight overweight JJ cord-023095-4dannjjm 5621 12 cats cat NNS cord-023095-4dannjjm 5621 13 did do VBD cord-023095-4dannjjm 5621 14 not not RB cord-023095-4dannjjm 5621 15 differ differ VB cord-023095-4dannjjm 5621 16 in in IN cord-023095-4dannjjm 5621 17 anesthetized anesthetize VBN cord-023095-4dannjjm 5621 18 cats cat NNS cord-023095-4dannjjm 5621 19 . . . cord-023095-4dannjjm 5622 1 These these DT cord-023095-4dannjjm 5622 2 results result NNS cord-023095-4dannjjm 5622 3 suggest suggest VBP cord-023095-4dannjjm 5622 4 that that IN cord-023095-4dannjjm 5622 5 obesity obesity NN cord-023095-4dannjjm 5622 6 and and CC cord-023095-4dannjjm 5622 7 overweight overweight NN cord-023095-4dannjjm 5622 8 did do VBD cord-023095-4dannjjm 5622 9 not not RB cord-023095-4dannjjm 5622 10 result result VB cord-023095-4dannjjm 5622 11 in in IN cord-023095-4dannjjm 5622 12 impairment impairment NN cord-023095-4dannjjm 5622 13 of of IN cord-023095-4dannjjm 5622 14 respiratory respiratory JJ cord-023095-4dannjjm 5622 15 function function NN cord-023095-4dannjjm 5622 16 in in IN cord-023095-4dannjjm 5622 17 cats cat NNS cord-023095-4dannjjm 5622 18 and and CC cord-023095-4dannjjm 5622 19 propofol propofol NN cord-023095-4dannjjm 5622 20 induced induce VBD cord-023095-4dannjjm 5622 21 respiratory respiratory JJ cord-023095-4dannjjm 5622 22 depression depression NN cord-023095-4dannjjm 5622 23 . . . cord-023095-4dannjjm 5623 1 Osteosarcoma Osteosarcoma NNP cord-023095-4dannjjm 5623 2 ( ( -LRB- cord-023095-4dannjjm 5623 3 OSA OSA NNP cord-023095-4dannjjm 5623 4 ) ) -RRB- cord-023095-4dannjjm 5623 5 is be VBZ cord-023095-4dannjjm 5623 6 the the DT cord-023095-4dannjjm 5623 7 most most RBS cord-023095-4dannjjm 5623 8 common common JJ cord-023095-4dannjjm 5623 9 bone bone NN cord-023095-4dannjjm 5623 10 tumor tumor NN cord-023095-4dannjjm 5623 11 in in IN cord-023095-4dannjjm 5623 12 dogs dog NNS cord-023095-4dannjjm 5623 13 , , , cord-023095-4dannjjm 5623 14 however however RB cord-023095-4dannjjm 5623 15 , , , cord-023095-4dannjjm 5623 16 little little JJ cord-023095-4dannjjm 5623 17 is be VBZ cord-023095-4dannjjm 5623 18 known know VBN cord-023095-4dannjjm 5623 19 regarding regard VBG cord-023095-4dannjjm 5623 20 the the DT cord-023095-4dannjjm 5623 21 mechanisms mechanism NNS cord-023095-4dannjjm 5623 22 underlying underlie VBG cord-023095-4dannjjm 5623 23 malignant malignant JJ cord-023095-4dannjjm 5623 24 transformation transformation NN cord-023095-4dannjjm 5623 25 in in IN cord-023095-4dannjjm 5623 26 these these DT cord-023095-4dannjjm 5623 27 tumors tumor NNS cord-023095-4dannjjm 5623 28 . . . cord-023095-4dannjjm 5624 1 Breeds breed NNS cord-023095-4dannjjm 5624 2 such such JJ cord-023095-4dannjjm 5624 3 as as IN cord-023095-4dannjjm 5624 4 Rottweilers rottweiler NNS cord-023095-4dannjjm 5624 5 and and CC cord-023095-4dannjjm 5624 6 Greyhounds greyhound NNS cord-023095-4dannjjm 5624 7 are be VBP cord-023095-4dannjjm 5624 8 at at IN cord-023095-4dannjjm 5624 9 higher high JJR cord-023095-4dannjjm 5624 10 risk risk NN cord-023095-4dannjjm 5624 11 for for IN cord-023095-4dannjjm 5624 12 developing develop VBG cord-023095-4dannjjm 5624 13 OSA OSA NNP cord-023095-4dannjjm 5624 14 , , , cord-023095-4dannjjm 5624 15 suggesting suggest VBG cord-023095-4dannjjm 5624 16 that that IN cord-023095-4dannjjm 5624 17 heritable heritable JJ cord-023095-4dannjjm 5624 18 factors factor NNS cord-023095-4dannjjm 5624 19 play play VBP cord-023095-4dannjjm 5624 20 a a DT cord-023095-4dannjjm 5624 21 role role NN cord-023095-4dannjjm 5624 22 in in IN cord-023095-4dannjjm 5624 23 this this DT cord-023095-4dannjjm 5624 24 disease disease NN cord-023095-4dannjjm 5624 25 . . . cord-023095-4dannjjm 5625 1 MiRNAs MiRNAs NNP cord-023095-4dannjjm 5626 1 have have VBP cord-023095-4dannjjm 5626 2 tumor tumor NN cord-023095-4dannjjm 5626 3 / / SYM cord-023095-4dannjjm 5626 4 tissue tissue NN cord-023095-4dannjjm 5626 5 specific specific JJ cord-023095-4dannjjm 5626 6 roles role NNS cord-023095-4dannjjm 5626 7 in in IN cord-023095-4dannjjm 5626 8 regulating regulate VBG cord-023095-4dannjjm 5626 9 gene gene NN cord-023095-4dannjjm 5626 10 expression expression NN cord-023095-4dannjjm 5626 11 and and CC cord-023095-4dannjjm 5626 12 dysregulated dysregulate VBN cord-023095-4dannjjm 5626 13 miRNA miRNA NNP cord-023095-4dannjjm 5626 14 expression expression NN cord-023095-4dannjjm 5626 15 is be VBZ cord-023095-4dannjjm 5626 16 found find VBN cord-023095-4dannjjm 5626 17 frequently frequently RB cord-023095-4dannjjm 5626 18 in in IN cord-023095-4dannjjm 5626 19 cancer cancer NN cord-023095-4dannjjm 5626 20 . . . cord-023095-4dannjjm 5627 1 We -PRON- PRP cord-023095-4dannjjm 5627 2 hypothesize hypothesize VBP cord-023095-4dannjjm 5627 3 that that IN cord-023095-4dannjjm 5627 4 canine canine JJ cord-023095-4dannjjm 5627 5 OSA OSA NNP cord-023095-4dannjjm 5627 6 is be VBZ cord-023095-4dannjjm 5627 7 characterized characterize VBN cord-023095-4dannjjm 5627 8 by by IN cord-023095-4dannjjm 5627 9 a a DT cord-023095-4dannjjm 5627 10 unique unique JJ cord-023095-4dannjjm 5627 11 miRNA miRNA NNP cord-023095-4dannjjm 5627 12 expression expression NN cord-023095-4dannjjm 5627 13 profile(s profile(s RB cord-023095-4dannjjm 5627 14 ) ) -RRB- cord-023095-4dannjjm 5627 15 with with IN cord-023095-4dannjjm 5627 16 dysregulation dysregulation NN cord-023095-4dannjjm 5627 17 of of IN cord-023095-4dannjjm 5627 18 some some DT cord-023095-4dannjjm 5627 19 miRNAs mirna NNS cord-023095-4dannjjm 5627 20 being be VBG cord-023095-4dannjjm 5627 21 associated associate VBN cord-023095-4dannjjm 5627 22 with with IN cord-023095-4dannjjm 5627 23 specific specific JJ cord-023095-4dannjjm 5627 24 breeds breed NNS cord-023095-4dannjjm 5627 25 . . . cord-023095-4dannjjm 5628 1 MiRNA MiRNA NNP cord-023095-4dannjjm 5628 2 expression expression NN cord-023095-4dannjjm 5628 3 profiling profiling NN cord-023095-4dannjjm 5628 4 of of IN cord-023095-4dannjjm 5628 5 primary primary JJ cord-023095-4dannjjm 5628 6 OSA OSA NNP cord-023095-4dannjjm 5628 7 tumors tumor NNS cord-023095-4dannjjm 5628 8 from from IN cord-023095-4dannjjm 5628 9 6 6 CD cord-023095-4dannjjm 5628 10 Greyhounds greyhound NNS cord-023095-4dannjjm 5628 11 and and CC cord-023095-4dannjjm 5628 12 6 6 CD cord-023095-4dannjjm 5628 13 Rottweilers Rottweilers NNPS cord-023095-4dannjjm 5628 14 was be VBD cord-023095-4dannjjm 5628 15 performed perform VBN cord-023095-4dannjjm 5628 16 using use VBG cord-023095-4dannjjm 5628 17 the the DT cord-023095-4dannjjm 5628 18 Nanostring Nanostring NNP cord-023095-4dannjjm 5628 19 Technologies Technologies NNPS cord-023095-4dannjjm 5628 20 nCounter nCounter NNP cord-023095-4dannjjm 5628 21 miRNA miRNA NNP cord-023095-4dannjjm 5628 22 Expression Expression NNP cord-023095-4dannjjm 5628 23 Assay Assay NNP cord-023095-4dannjjm 5628 24 Kit Kit NNP cord-023095-4dannjjm 5628 25 , , , cord-023095-4dannjjm 5628 26 interrogating interrogate VBG cord-023095-4dannjjm 5628 27 the the DT cord-023095-4dannjjm 5628 28 miRNA miRNA NNP cord-023095-4dannjjm 5628 29 expression expression NN cord-023095-4dannjjm 5628 30 profile profile NN cord-023095-4dannjjm 5628 31 of of IN cord-023095-4dannjjm 5628 32 651 651 CD cord-023095-4dannjjm 5628 33 human human JJ cord-023095-4dannjjm 5628 34 miRNAs miRNAs NNP cord-023095-4dannjjm 5628 35 , , , cord-023095-4dannjjm 5628 36 168 168 CD cord-023095-4dannjjm 5628 37 of of IN cord-023095-4dannjjm 5628 38 whose whose WP$ cord-023095-4dannjjm 5628 39 mature mature JJ cord-023095-4dannjjm 5628 40 sequences sequence NNS cord-023095-4dannjjm 5628 41 are be VBP cord-023095-4dannjjm 5628 42 100 100 CD cord-023095-4dannjjm 5628 43 % % NN cord-023095-4dannjjm 5628 44 conserved conserve VBN cord-023095-4dannjjm 5628 45 between between IN cord-023095-4dannjjm 5628 46 human human NN cord-023095-4dannjjm 5628 47 and and CC cord-023095-4dannjjm 5628 48 dog dog NN cord-023095-4dannjjm 5628 49 . . . cord-023095-4dannjjm 5629 1 17 17 CD cord-023095-4dannjjm 5629 2 miRNAs mirna NNS cord-023095-4dannjjm 5629 3 were be VBD cord-023095-4dannjjm 5629 4 differentially differentially RB cord-023095-4dannjjm 5629 5 expressed express VBN cord-023095-4dannjjm 5629 6 in in IN cord-023095-4dannjjm 5629 7 Greyhound Greyhound NNP cord-023095-4dannjjm 5629 8 versus versus IN cord-023095-4dannjjm 5629 9 Rottweiler Rottweiler NNP cord-023095-4dannjjm 5629 10 tumors tumor NNS cord-023095-4dannjjm 5629 11 ( ( -LRB- cord-023095-4dannjjm 5629 12 p p NN cord-023095-4dannjjm 5629 13 o o NN cord-023095-4dannjjm 5629 14 0.05 0.05 CD cord-023095-4dannjjm 5629 15 ) ) -RRB- cord-023095-4dannjjm 5629 16 , , , cord-023095-4dannjjm 5629 17 suggesting suggest VBG cord-023095-4dannjjm 5629 18 that that IN cord-023095-4dannjjm 5629 19 breed breed NN cord-023095-4dannjjm 5629 20 - - HYPH cord-023095-4dannjjm 5629 21 specific specific JJ cord-023095-4dannjjm 5629 22 dysregulation dysregulation NN cord-023095-4dannjjm 5629 23 of of IN cord-023095-4dannjjm 5629 24 miRNAs miRNAs NNP cord-023095-4dannjjm 5629 25 may may MD cord-023095-4dannjjm 5629 26 contribute contribute VB cord-023095-4dannjjm 5629 27 to to IN cord-023095-4dannjjm 5629 28 the the DT cord-023095-4dannjjm 5629 29 development development NN cord-023095-4dannjjm 5629 30 and and CC cord-023095-4dannjjm 5629 31 progression progression NN cord-023095-4dannjjm 5629 32 of of IN cord-023095-4dannjjm 5629 33 spontaneous spontaneous JJ cord-023095-4dannjjm 5629 34 OSA OSA NNP cord-023095-4dannjjm 5629 35 . . . cord-023095-4dannjjm 5630 1 Hierarchical hierarchical JJ cord-023095-4dannjjm 5630 2 clustering clustering NN cord-023095-4dannjjm 5630 3 revealed reveal VBD cord-023095-4dannjjm 5630 4 distinct distinct JJ cord-023095-4dannjjm 5630 5 miRNA miRNA NNP cord-023095-4dannjjm 5630 6 expression expression NN cord-023095-4dannjjm 5630 7 signatures signature NNS cord-023095-4dannjjm 5630 8 in in IN cord-023095-4dannjjm 5630 9 Greyhound Greyhound NNP cord-023095-4dannjjm 5630 10 OSA OSA NNP cord-023095-4dannjjm 5630 11 tumors tumor NNS cord-023095-4dannjjm 5630 12 as as IN cord-023095-4dannjjm 5630 13 compared compare VBN cord-023095-4dannjjm 5630 14 to to IN cord-023095-4dannjjm 5630 15 Rottweilers rottweiler NNS cord-023095-4dannjjm 5630 16 . . . cord-023095-4dannjjm 5631 1 Based base VBN cord-023095-4dannjjm 5631 2 on on IN cord-023095-4dannjjm 5631 3 these these DT cord-023095-4dannjjm 5631 4 preliminary preliminary JJ cord-023095-4dannjjm 5631 5 results result NNS cord-023095-4dannjjm 5631 6 , , , cord-023095-4dannjjm 5631 7 we -PRON- PRP cord-023095-4dannjjm 5631 8 are be VBP cord-023095-4dannjjm 5631 9 evaluating evaluate VBG cord-023095-4dannjjm 5631 10 a a DT cord-023095-4dannjjm 5631 11 larger large JJR cord-023095-4dannjjm 5631 12 cohort cohort NN cord-023095-4dannjjm 5631 13 of of IN cord-023095-4dannjjm 5631 14 OSA OSA NNP cord-023095-4dannjjm 5631 15 tumor tumor NN cord-023095-4dannjjm 5631 16 samples sample NNS cord-023095-4dannjjm 5631 17 including include VBG cord-023095-4dannjjm 5631 18 Greyhounds greyhound NNS cord-023095-4dannjjm 5631 19 , , , cord-023095-4dannjjm 5631 20 Rottweilers Rottweilers NNPS cord-023095-4dannjjm 5631 21 , , , cord-023095-4dannjjm 5631 22 Golden Golden NNP cord-023095-4dannjjm 5631 23 Retrievers Retrievers NNPS cord-023095-4dannjjm 5631 24 , , , cord-023095-4dannjjm 5631 25 and and CC cord-023095-4dannjjm 5631 26 a a DT cord-023095-4dannjjm 5631 27 mixed mixed JJ cord-023095-4dannjjm 5631 28 population population NN cord-023095-4dannjjm 5631 29 of of IN cord-023095-4dannjjm 5631 30 other other JJ cord-023095-4dannjjm 5631 31 breeds breed NNS cord-023095-4dannjjm 5631 32 . . . cord-023095-4dannjjm 5632 1 Statistical statistical JJ cord-023095-4dannjjm 5632 2 analysis analysis NN cord-023095-4dannjjm 5632 3 will will MD cord-023095-4dannjjm 5632 4 be be VB cord-023095-4dannjjm 5632 5 performed perform VBN cord-023095-4dannjjm 5632 6 to to TO cord-023095-4dannjjm 5632 7 determine determine VB cord-023095-4dannjjm 5632 8 the the DT cord-023095-4dannjjm 5632 9 association association NNP cord-023095-4dannjjm 5632 10 of of IN cord-023095-4dannjjm 5632 11 miRNA miRNA NNP cord-023095-4dannjjm 5632 12 transcript transcript NNP cord-023095-4dannjjm 5632 13 levels level NNS cord-023095-4dannjjm 5632 14 with with IN cord-023095-4dannjjm 5632 15 specific specific JJ cord-023095-4dannjjm 5632 16 breeds breed NNS cord-023095-4dannjjm 5632 17 and and CC cord-023095-4dannjjm 5632 18 overall overall JJ cord-023095-4dannjjm 5632 19 outcome outcome NN cord-023095-4dannjjm 5632 20 . . . cord-023095-4dannjjm 5633 1 Characterization characterization NN cord-023095-4dannjjm 5633 2 of of IN cord-023095-4dannjjm 5633 3 miRNA miRNA NNP cord-023095-4dannjjm 5633 4 expression expression NN cord-023095-4dannjjm 5633 5 in in IN cord-023095-4dannjjm 5633 6 canine canine JJ cord-023095-4dannjjm 5633 7 OSA OSA NNP cord-023095-4dannjjm 5633 8 will will MD cord-023095-4dannjjm 5633 9 facilitate facilitate VB cord-023095-4dannjjm 5633 10 our -PRON- PRP$ cord-023095-4dannjjm 5633 11 understanding understanding NN cord-023095-4dannjjm 5633 12 the the DT cord-023095-4dannjjm 5633 13 biology biology NN cord-023095-4dannjjm 5633 14 of of IN cord-023095-4dannjjm 5633 15 this this DT cord-023095-4dannjjm 5633 16 disease disease NN cord-023095-4dannjjm 5633 17 and and CC cord-023095-4dannjjm 5633 18 has have VBZ cord-023095-4dannjjm 5633 19 the the DT cord-023095-4dannjjm 5633 20 potential potential NN cord-023095-4dannjjm 5633 21 to to TO cord-023095-4dannjjm 5633 22 identify identify VB cord-023095-4dannjjm 5633 23 targets target NNS cord-023095-4dannjjm 5633 24 for for IN cord-023095-4dannjjm 5633 25 therapeutic therapeutic JJ cord-023095-4dannjjm 5633 26 intervention intervention NN cord-023095-4dannjjm 5633 27 . . . cord-023095-4dannjjm 5634 1 Originally originally RB cord-023095-4dannjjm 5634 2 Combination combination NN cord-023095-4dannjjm 5634 3 therapies therapy NNS cord-023095-4dannjjm 5634 4 using use VBG cord-023095-4dannjjm 5634 5 drugs drug NNS cord-023095-4dannjjm 5634 6 with with IN cord-023095-4dannjjm 5634 7 documented document VBN cord-023095-4dannjjm 5634 8 single single JJ cord-023095-4dannjjm 5634 9 - - HYPH cord-023095-4dannjjm 5634 10 agent agent NN cord-023095-4dannjjm 5634 11 activity activity NN cord-023095-4dannjjm 5634 12 and and CC cord-023095-4dannjjm 5634 13 lack lack NN cord-023095-4dannjjm 5634 14 of of IN cord-023095-4dannjjm 5634 15 overlapping overlap VBG cord-023095-4dannjjm 5634 16 toxicities toxicity NNS cord-023095-4dannjjm 5634 17 could could MD cord-023095-4dannjjm 5634 18 potentially potentially RB cord-023095-4dannjjm 5634 19 improve improve VB cord-023095-4dannjjm 5634 20 outcome outcome NN cord-023095-4dannjjm 5634 21 . . . cord-023095-4dannjjm 5635 1 The the DT cord-023095-4dannjjm 5635 2 hypothesis hypothesis NN cord-023095-4dannjjm 5635 3 intended intend VBD cord-023095-4dannjjm 5635 4 to to TO cord-023095-4dannjjm 5635 5 be be VB cord-023095-4dannjjm 5635 6 tested test VBN cord-023095-4dannjjm 5635 7 is be VBZ cord-023095-4dannjjm 5635 8 that that IN cord-023095-4dannjjm 5635 9 Palladia Palladia NNP cord-023095-4dannjjm 5635 10 s s NN cord-023095-4dannjjm 5635 11 can can MD cord-023095-4dannjjm 5635 12 be be VB cord-023095-4dannjjm 5635 13 safely safely RB cord-023095-4dannjjm 5635 14 administered administer VBN cord-023095-4dannjjm 5635 15 concurrently concurrently RB cord-023095-4dannjjm 5635 16 with with IN cord-023095-4dannjjm 5635 17 a a DT cord-023095-4dannjjm 5635 18 standard standard JJ cord-023095-4dannjjm 5635 19 weekly weekly JJ cord-023095-4dannjjm 5635 20 protocol protocol NN cord-023095-4dannjjm 5635 21 of of IN cord-023095-4dannjjm 5635 22 vinblastine vinblastine NN cord-023095-4dannjjm 5635 23 ( ( -LRB- cord-023095-4dannjjm 5635 24 VBL VBL NNP cord-023095-4dannjjm 5635 25 ) ) -RRB- cord-023095-4dannjjm 5635 26 , , , cord-023095-4dannjjm 5635 27 at at IN cord-023095-4dannjjm 5635 28 dosages dosage NNS cord-023095-4dannjjm 5635 29 known know VBN cord-023095-4dannjjm 5635 30 to to TO cord-023095-4dannjjm 5635 31 have have VB cord-023095-4dannjjm 5635 32 activity activity NN cord-023095-4dannjjm 5635 33 against against IN cord-023095-4dannjjm 5635 34 mast mast JJ cord-023095-4dannjjm 5635 35 cell cell NN cord-023095-4dannjjm 5635 36 tumors tumor NNS cord-023095-4dannjjm 5635 37 . . . cord-023095-4dannjjm 5636 1 Dogs dog NNS cord-023095-4dannjjm 5636 2 with with IN cord-023095-4dannjjm 5636 3 histologically histologically RB cord-023095-4dannjjm 5636 4 confirmed confirm VBN cord-023095-4dannjjm 5636 5 measurable measurable JJ cord-023095-4dannjjm 5636 6 mast mast JJ cord-023095-4dannjjm 5636 7 cell cell NN cord-023095-4dannjjm 5636 8 tumors tumor NNS cord-023095-4dannjjm 5636 9 were be VBD cord-023095-4dannjjm 5636 10 evaluated evaluate VBN cord-023095-4dannjjm 5636 11 for for IN cord-023095-4dannjjm 5636 12 eligibility eligibility NN cord-023095-4dannjjm 5636 13 to to TO cord-023095-4dannjjm 5636 14 enter enter VB cord-023095-4dannjjm 5636 15 a a DT cord-023095-4dannjjm 5636 16 standard standard JJ cord-023095-4dannjjm 5636 17 phase phase NN cord-023095-4dannjjm 5636 18 I -PRON- PRP cord-023095-4dannjjm 5636 19 dose dose RB cord-023095-4dannjjm 5636 20 - - HYPH cord-023095-4dannjjm 5636 21 finding find VBG cord-023095-4dannjjm 5636 22 trial trial NN cord-023095-4dannjjm 5636 23 ( ( -LRB- cord-023095-4dannjjm 5636 24 313 313 CD cord-023095-4dannjjm 5636 25 cohort cohort NN cord-023095-4dannjjm 5636 26 ) ) -RRB- cord-023095-4dannjjm 5636 27 , , , cord-023095-4dannjjm 5636 28 at at IN cord-023095-4dannjjm 5636 29 a a DT cord-023095-4dannjjm 5636 30 starting starting NN cord-023095-4dannjjm 5636 31 dose dose NN cord-023095-4dannjjm 5636 32 of of IN cord-023095-4dannjjm 5636 33 2.3 2.3 CD cord-023095-4dannjjm 5636 34 mg mg NNP cord-023095-4dannjjm 5636 35 / / SYM cord-023095-4dannjjm 5636 36 m2 m2 NNP cord-023095-4dannjjm 5636 37 IV IV NNP cord-023095-4dannjjm 5636 38 VBL VBL NNP cord-023095-4dannjjm 5636 39 ( ( -LRB- cord-023095-4dannjjm 5636 40 weekly weekly NN cord-023095-4dannjjm 5636 41 for for IN cord-023095-4dannjjm 5636 42 a a DT cord-023095-4dannjjm 5636 43 total total NN cord-023095-4dannjjm 5636 44 of of IN cord-023095-4dannjjm 5636 45 4 4 CD cord-023095-4dannjjm 5636 46 treatments treatment NNS cord-023095-4dannjjm 5636 47 ) ) -RRB- cord-023095-4dannjjm 5636 48 and and CC cord-023095-4dannjjm 5637 1 2.25 2.25 CD cord-023095-4dannjjm 5637 2 mg mg NNP cord-023095-4dannjjm 5637 3 / / SYM cord-023095-4dannjjm 5637 4 kg kg NNP cord-023095-4dannjjm 5637 5 PO PO NNP cord-023095-4dannjjm 5637 6 Palladia Palladia NNP cord-023095-4dannjjm 5637 7 s s NNP cord-023095-4dannjjm 5637 8 EOD EOD NNP cord-023095-4dannjjm 5637 9 , , , cord-023095-4dannjjm 5637 10 concurrently concurrently RB cord-023095-4dannjjm 5637 11 . . . cord-023095-4dannjjm 5638 1 Dose dose JJ cord-023095-4dannjjm 5638 2 escalation escalation NN cord-023095-4dannjjm 5638 3 of of IN cord-023095-4dannjjm 5638 4 Palladia Palladia NNP cord-023095-4dannjjm 5638 5 s s NNP cord-023095-4dannjjm 5638 6 was be VBD cord-023095-4dannjjm 5638 7 scheduled schedule VBN cord-023095-4dannjjm 5638 8 in in IN cord-023095-4dannjjm 5638 9 0.25 0.25 CD cord-023095-4dannjjm 5638 10 mg mg NNP cord-023095-4dannjjm 5638 11 / / SYM cord-023095-4dannjjm 5638 12 kg kg NN cord-023095-4dannjjm 5638 13 increments increment NNS cord-023095-4dannjjm 5638 14 until until IN cord-023095-4dannjjm 5638 15 MTD MTD NNP cord-023095-4dannjjm 5638 16 was be VBD cord-023095-4dannjjm 5638 17 established establish VBN cord-023095-4dannjjm 5638 18 or or CC cord-023095-4dannjjm 5638 19 FDA FDA NNP cord-023095-4dannjjm 5638 20 label label NN cord-023095-4dannjjm 5638 21 dose dose NN cord-023095-4dannjjm 5638 22 completed complete VBD cord-023095-4dannjjm 5638 23 ( ( -LRB- cord-023095-4dannjjm 5638 24 3.25 3.25 CD cord-023095-4dannjjm 5638 25 mg mg NNP cord-023095-4dannjjm 5638 26 / / SYM cord-023095-4dannjjm 5638 27 kg kg NNP cord-023095-4dannjjm 5638 28 ) ) -RRB- cord-023095-4dannjjm 5638 29 . . . cord-023095-4dannjjm 5639 1 Safety safety NN cord-023095-4dannjjm 5639 2 evaluation evaluation NN cord-023095-4dannjjm 5639 3 was be VBD cord-023095-4dannjjm 5639 4 performed perform VBN cord-023095-4dannjjm 5639 5 weekly weekly RB cord-023095-4dannjjm 5639 6 throughout throughout IN cord-023095-4dannjjm 5639 7 the the DT cord-023095-4dannjjm 5639 8 4 4 CD cord-023095-4dannjjm 5639 9 week week NN cord-023095-4dannjjm 5639 10 study study NN cord-023095-4dannjjm 5639 11 period period NN cord-023095-4dannjjm 5639 12 . . . cord-023095-4dannjjm 5640 1 Dose dose NN cord-023095-4dannjjm 5640 2 - - HYPH cord-023095-4dannjjm 5640 3 limiting limit VBG cord-023095-4dannjjm 5640 4 toxicities toxicity NNS cord-023095-4dannjjm 5640 5 were be VBD cord-023095-4dannjjm 5640 6 described describe VBN cord-023095-4dannjjm 5640 7 following follow VBG cord-023095-4dannjjm 5640 8 established establish VBN cord-023095-4dannjjm 5640 9 VCOG VCOG NNP cord-023095-4dannjjm 5640 10 - - HYPH cord-023095-4dannjjm 5640 11 CTCAE(v1.0 CTCAE(v1.0 NNP cord-023095-4dannjjm 5640 12 ) ) -RRB- cord-023095-4dannjjm 5640 13 criteria criterion NNS cord-023095-4dannjjm 5640 14 . . . cord-023095-4dannjjm 5641 1 While while IN cord-023095-4dannjjm 5641 2 antitumor antitumor JJ cord-023095-4dannjjm 5641 3 response response NN cord-023095-4dannjjm 5641 4 is be VBZ cord-023095-4dannjjm 5641 5 not not RB cord-023095-4dannjjm 5641 6 a a DT cord-023095-4dannjjm 5641 7 primary primary JJ cord-023095-4dannjjm 5641 8 endpoint endpoint NN cord-023095-4dannjjm 5641 9 of of IN cord-023095-4dannjjm 5641 10 phase phase NN cord-023095-4dannjjm 5642 1 I -PRON- PRP cord-023095-4dannjjm 5642 2 trials trial NNS cord-023095-4dannjjm 5642 3 , , , cord-023095-4dannjjm 5642 4 activity activity NN cord-023095-4dannjjm 5642 5 was be VBD cord-023095-4dannjjm 5642 6 documented document VBN cord-023095-4dannjjm 5642 7 prior prior RB cord-023095-4dannjjm 5642 8 to to IN cord-023095-4dannjjm 5642 9 VBL VBL NNP cord-023095-4dannjjm 5642 10 treatments treatment NNS cord-023095-4dannjjm 5642 11 2 2 CD cord-023095-4dannjjm 5642 12 - - SYM cord-023095-4dannjjm 5642 13 4 4 CD cord-023095-4dannjjm 5642 14 , , , cord-023095-4dannjjm 5642 15 and and CC cord-023095-4dannjjm 5643 1 monthly monthly RB cord-023095-4dannjjm 5643 2 thereafter thereafter RB cord-023095-4dannjjm 5643 3 , , , cord-023095-4dannjjm 5643 4 based base VBN cord-023095-4dannjjm 5643 5 on on IN cord-023095-4dannjjm 5643 6 RECIST RECIST NNP cord-023095-4dannjjm 5643 7 criteria criterion NNS cord-023095-4dannjjm 5643 8 . . . cord-023095-4dannjjm 5644 1 Nine nine CD cord-023095-4dannjjm 5644 2 dogs dog NNS cord-023095-4dannjjm 5644 3 have have VBP cord-023095-4dannjjm 5644 4 been be VBN cord-023095-4dannjjm 5644 5 enrolled enrol VBN cord-023095-4dannjjm 5644 6 ; ; : cord-023095-4dannjjm 5644 7 cohort cohort NN cord-023095-4dannjjm 5644 8 3 3 CD cord-023095-4dannjjm 5644 9 is be VBZ cord-023095-4dannjjm 5644 10 filled fill VBN cord-023095-4dannjjm 5644 11 and and CC cord-023095-4dannjjm 5644 12 approaching approach VBG cord-023095-4dannjjm 5644 13 completion completion NN cord-023095-4dannjjm 5644 14 of of IN cord-023095-4dannjjm 5644 15 the the DT cord-023095-4dannjjm 5644 16 evaluation evaluation NN cord-023095-4dannjjm 5644 17 period period NN cord-023095-4dannjjm 5644 18 . . . cord-023095-4dannjjm 5645 1 Hematologic Hematologic NNP cord-023095-4dannjjm 5645 2 dose dose VBD cord-023095-4dannjjm 5645 3 limiting limit VBG cord-023095-4dannjjm 5645 4 toxicity toxicity NN cord-023095-4dannjjm 5645 5 led lead VBD cord-023095-4dannjjm 5645 6 to to IN cord-023095-4dannjjm 5645 7 2 2 CD cord-023095-4dannjjm 5645 8 de de NNS cord-023095-4dannjjm 5645 9 - - HYPH cord-023095-4dannjjm 5645 10 escalations escalation NNS cord-023095-4dannjjm 5645 11 of of IN cord-023095-4dannjjm 5645 12 VBL VBL NNP cord-023095-4dannjjm 5645 13 . . . cord-023095-4dannjjm 5646 1 The the DT cord-023095-4dannjjm 5646 2 current current JJ cord-023095-4dannjjm 5646 3 safe safe JJ cord-023095-4dannjjm 5646 4 combination combination NN cord-023095-4dannjjm 5646 5 appears appear VBZ cord-023095-4dannjjm 5646 6 to to TO cord-023095-4dannjjm 5646 7 include include VB cord-023095-4dannjjm 5646 8 VBL VBL NNP cord-023095-4dannjjm 5646 9 at at IN cord-023095-4dannjjm 5646 10 1.6 1.6 CD cord-023095-4dannjjm 5646 11 mg mg NNP cord-023095-4dannjjm 5646 12 / / SYM cord-023095-4dannjjm 5646 13 m2 m2 NNP cord-023095-4dannjjm 5646 14 every every DT cord-023095-4dannjjm 5646 15 other other JJ cord-023095-4dannjjm 5646 16 week week NN cord-023095-4dannjjm 5646 17 and and CC cord-023095-4dannjjm 5646 18 Palladia Palladia NNP cord-023095-4dannjjm 5646 19 s s NNP cord-023095-4dannjjm 5646 20 at at IN cord-023095-4dannjjm 5646 21 2.25 2.25 CD cord-023095-4dannjjm 5646 22 mg mg NNP cord-023095-4dannjjm 5646 23 / / SYM cord-023095-4dannjjm 5646 24 kg kg NNP cord-023095-4dannjjm 5646 25 EOD EOD NNP cord-023095-4dannjjm 5646 26 . . . cord-023095-4dannjjm 5647 1 Response response NN cord-023095-4dannjjm 5647 2 was be VBD cord-023095-4dannjjm 5647 3 seen see VBN cord-023095-4dannjjm 5647 4 in in IN cord-023095-4dannjjm 5647 5 all all DT cord-023095-4dannjjm 5647 6 but but IN cord-023095-4dannjjm 5647 7 one one CD cord-023095-4dannjjm 5647 8 dog dog NN cord-023095-4dannjjm 5647 9 . . . cord-023095-4dannjjm 5648 1 Without without IN cord-023095-4dannjjm 5648 2 head head NN cord-023095-4dannjjm 5648 3 to to IN cord-023095-4dannjjm 5648 4 head head VB cord-023095-4dannjjm 5648 5 trials trial NNS cord-023095-4dannjjm 5648 6 comparing compare VBG cord-023095-4dannjjm 5648 7 efficacy efficacy NN cord-023095-4dannjjm 5648 8 of of IN cord-023095-4dannjjm 5648 9 bi bi JJ cord-023095-4dannjjm 5648 10 - - JJ cord-023095-4dannjjm 5648 11 weekly weekly JJ cord-023095-4dannjjm 5648 12 VBL VBL NNP cord-023095-4dannjjm 5648 13 combined combine VBN cord-023095-4dannjjm 5648 14 with with IN cord-023095-4dannjjm 5648 15 Palladia Palladia NNP cord-023095-4dannjjm 5648 16 s s NNP cord-023095-4dannjjm 5648 17 and and CC cord-023095-4dannjjm 5648 18 VBL VBL NNP cord-023095-4dannjjm 5648 19 alone alone RB cord-023095-4dannjjm 5648 20 , , , cord-023095-4dannjjm 5648 21 choice choice NN cord-023095-4dannjjm 5648 22 of of IN cord-023095-4dannjjm 5648 23 therapy therapy NN cord-023095-4dannjjm 5648 24 should should MD cord-023095-4dannjjm 5648 25 remain remain VB cord-023095-4dannjjm 5648 26 at at IN cord-023095-4dannjjm 5648 27 the the DT cord-023095-4dannjjm 5648 28 clinician clinician NN cord-023095-4dannjjm 5648 29 's 's POS cord-023095-4dannjjm 5648 30 discretion discretion NN cord-023095-4dannjjm 5648 31 . . . cord-023095-4dannjjm 5649 1 Originally originally RB cord-023095-4dannjjm 5649 2 Prostate prostate NN cord-023095-4dannjjm 5649 3 specific specific JJ cord-023095-4dannjjm 5649 4 membrane membrane NN cord-023095-4dannjjm 5649 5 antigen antigen NN cord-023095-4dannjjm 5649 6 ( ( -LRB- cord-023095-4dannjjm 5649 7 PSMA PSMA NNP cord-023095-4dannjjm 5649 8 ) ) -RRB- cord-023095-4dannjjm 5649 9 is be VBZ cord-023095-4dannjjm 5649 10 a a DT cord-023095-4dannjjm 5649 11 transmembrane transmembrane NN cord-023095-4dannjjm 5649 12 protein protein NN cord-023095-4dannjjm 5649 13 expressed express VBN cord-023095-4dannjjm 5649 14 by by IN cord-023095-4dannjjm 5649 15 tumor tumor NN cord-023095-4dannjjm 5649 16 - - HYPH cord-023095-4dannjjm 5649 17 associated associate VBN cord-023095-4dannjjm 5649 18 neovasculature neovasculature NN cord-023095-4dannjjm 5649 19 , , , cord-023095-4dannjjm 5649 20 but but CC cord-023095-4dannjjm 5649 21 not not RB cord-023095-4dannjjm 5649 22 normal normal JJ cord-023095-4dannjjm 5649 23 blood blood NN cord-023095-4dannjjm 5649 24 vessels vessel NNS cord-023095-4dannjjm 5649 25 . . . cord-023095-4dannjjm 5650 1 Based base VBN cord-023095-4dannjjm 5650 2 upon upon IN cord-023095-4dannjjm 5650 3 its -PRON- PRP$ cord-023095-4dannjjm 5650 4 selective selective JJ cord-023095-4dannjjm 5650 5 expression expression NN cord-023095-4dannjjm 5650 6 in in IN cord-023095-4dannjjm 5650 7 endothelial endothelial JJ cord-023095-4dannjjm 5650 8 cells cell NNS cord-023095-4dannjjm 5650 9 associated associate VBN cord-023095-4dannjjm 5650 10 with with IN cord-023095-4dannjjm 5650 11 cancer cancer NN cord-023095-4dannjjm 5650 12 , , , cord-023095-4dannjjm 5650 13 PSMA PSMA NNP cord-023095-4dannjjm 5650 14 may may MD cord-023095-4dannjjm 5650 15 serve serve VB cord-023095-4dannjjm 5650 16 as as IN cord-023095-4dannjjm 5650 17 a a DT cord-023095-4dannjjm 5650 18 conserved conserved JJ cord-023095-4dannjjm 5650 19 angiogenic angiogenic JJ cord-023095-4dannjjm 5650 20 target target NN cord-023095-4dannjjm 5650 21 shared share VBN cord-023095-4dannjjm 5650 22 by by IN cord-023095-4dannjjm 5650 23 macroscopic macroscopic JJ cord-023095-4dannjjm 5650 24 solid solid JJ cord-023095-4dannjjm 5650 25 tumors tumor NNS cord-023095-4dannjjm 5650 26 of of IN cord-023095-4dannjjm 5650 27 various various JJ cord-023095-4dannjjm 5650 28 histologies histology NNS cord-023095-4dannjjm 5650 29 . . . cord-023095-4dannjjm 5651 1 To to TO cord-023095-4dannjjm 5651 2 investigate investigate VB cord-023095-4dannjjm 5651 3 the the DT cord-023095-4dannjjm 5651 4 feasibility feasibility NN cord-023095-4dannjjm 5651 5 of of IN cord-023095-4dannjjm 5651 6 targeting target VBG cord-023095-4dannjjm 5651 7 a a DT cord-023095-4dannjjm 5651 8 homogenous homogenous JJ cord-023095-4dannjjm 5651 9 population population NN cord-023095-4dannjjm 5651 10 of of IN cord-023095-4dannjjm 5651 11 PSMA PSMA NNP cord-023095-4dannjjm 5651 12 - - : cord-023095-4dannjjm 5651 13 expressing express VBG cord-023095-4dannjjm 5651 14 endothelial endothelial JJ cord-023095-4dannjjm 5651 15 cells cell NNS cord-023095-4dannjjm 5651 16 as as IN cord-023095-4dannjjm 5651 17 a a DT cord-023095-4dannjjm 5651 18 novel novel JJ cord-023095-4dannjjm 5651 19 anticancer anticancer JJ cord-023095-4dannjjm 5651 20 strategy strategy NN cord-023095-4dannjjm 5651 21 , , , cord-023095-4dannjjm 5651 22 we -PRON- PRP cord-023095-4dannjjm 5651 23 have have VBP cord-023095-4dannjjm 5651 24 investigated investigate VBN cord-023095-4dannjjm 5651 25 PSMA PSMA NNP cord-023095-4dannjjm 5651 26 expression expression NN cord-023095-4dannjjm 5651 27 in in IN cord-023095-4dannjjm 5651 28 several several JJ cord-023095-4dannjjm 5651 29 canine canine JJ cord-023095-4dannjjm 5651 30 hemangiosarcoma hemangiosarcoma NN cord-023095-4dannjjm 5651 31 ( ( -LRB- cord-023095-4dannjjm 5651 32 cHSA chsa JJ cord-023095-4dannjjm 5651 33 ) ) -RRB- cord-023095-4dannjjm 5651 34 cell cell NN cord-023095-4dannjjm 5651 35 lines line NNS cord-023095-4dannjjm 5651 36 , , , cord-023095-4dannjjm 5651 37 and and CC cord-023095-4dannjjm 5651 38 subsequently subsequently RB cord-023095-4dannjjm 5651 39 developed develop VBD cord-023095-4dannjjm 5651 40 self self NN cord-023095-4dannjjm 5651 41 - - HYPH cord-023095-4dannjjm 5651 42 assembling assemble VBG cord-023095-4dannjjm 5651 43 nanoparticles nanoparticle NNS cord-023095-4dannjjm 5651 44 containing contain VBG cord-023095-4dannjjm 5651 45 diagnostic diagnostic JJ cord-023095-4dannjjm 5651 46 ( ( -LRB- cord-023095-4dannjjm 5651 47 near near IN cord-023095-4dannjjm 5651 48 infrared infrared JJ cord-023095-4dannjjm 5651 49 dyes dye NNS cord-023095-4dannjjm 5651 50 ) ) -RRB- cord-023095-4dannjjm 5651 51 and and CC cord-023095-4dannjjm 5651 52 therapeutic therapeutic JJ cord-023095-4dannjjm 5651 53 ( ( -LRB- cord-023095-4dannjjm 5651 54 doxorubicin doxorubicin NN cord-023095-4dannjjm 5651 55 ) ) -RRB- cord-023095-4dannjjm 5651 56 cargo cargo NN cord-023095-4dannjjm 5651 57 which which WDT cord-023095-4dannjjm 5651 58 selectively selectively RB cord-023095-4dannjjm 5651 59 bind bind VBP cord-023095-4dannjjm 5651 60 to to IN cord-023095-4dannjjm 5651 61 PSMA PSMA NNP cord-023095-4dannjjm 5651 62 by by IN cord-023095-4dannjjm 5651 63 means mean NNS cord-023095-4dannjjm 5651 64 of of IN cord-023095-4dannjjm 5651 65 the the DT cord-023095-4dannjjm 5651 66 A10 A10 NNP cord-023095-4dannjjm 5651 67 aptamer aptamer NN cord-023095-4dannjjm 5651 68 , , , cord-023095-4dannjjm 5651 69 a a DT cord-023095-4dannjjm 5651 70 commercially commercially RB cord-023095-4dannjjm 5651 71 - - HYPH cord-023095-4dannjjm 5651 72 available available JJ cord-023095-4dannjjm 5651 73 oligonucleotide oligonucleotide NN cord-023095-4dannjjm 5651 74 . . . cord-023095-4dannjjm 5652 1 The the DT cord-023095-4dannjjm 5652 2 expression expression NN cord-023095-4dannjjm 5652 3 of of IN cord-023095-4dannjjm 5652 4 PSMA PSMA NNP cord-023095-4dannjjm 5652 5 by by IN cord-023095-4dannjjm 5652 6 cHSA chsa JJ cord-023095-4dannjjm 5652 7 cells cell NNS cord-023095-4dannjjm 5652 8 was be VBD cord-023095-4dannjjm 5652 9 confirmed confirm VBN cord-023095-4dannjjm 5652 10 transcriptionally transcriptionally RB cord-023095-4dannjjm 5652 11 and and CC cord-023095-4dannjjm 5652 12 translationally translationally RB cord-023095-4dannjjm 5652 13 by by IN cord-023095-4dannjjm 5652 14 real real JJ cord-023095-4dannjjm 5652 15 time time NN cord-023095-4dannjjm 5652 16 PCR pcr NN cord-023095-4dannjjm 5652 17 and and CC cord-023095-4dannjjm 5652 18 immunohistochemistry immunohistochemistry NN cord-023095-4dannjjm 5652 19 , , , cord-023095-4dannjjm 5652 20 respectively respectively RB cord-023095-4dannjjm 5652 21 . . . cord-023095-4dannjjm 5653 1 Selective selective JJ cord-023095-4dannjjm 5653 2 binding binding NN cord-023095-4dannjjm 5653 3 and and CC cord-023095-4dannjjm 5653 4 endocytosis endocytosis NN cord-023095-4dannjjm 5653 5 of of IN cord-023095-4dannjjm 5653 6 A10 A10 NNP cord-023095-4dannjjm 5653 7 decorated decorate VBN cord-023095-4dannjjm 5653 8 nanoparticles nanoparticle NNS cord-023095-4dannjjm 5653 9 was be VBD cord-023095-4dannjjm 5653 10 studied study VBN cord-023095-4dannjjm 5653 11 by by IN cord-023095-4dannjjm 5653 12 fluorescent fluorescent JJ cord-023095-4dannjjm 5653 13 microscopy microscopy NNS cord-023095-4dannjjm 5653 14 . . . cord-023095-4dannjjm 5654 1 The the DT cord-023095-4dannjjm 5654 2 ability ability NN cord-023095-4dannjjm 5654 3 of of IN cord-023095-4dannjjm 5654 4 A10 A10 NNP cord-023095-4dannjjm 5654 5 decorated decorate VBN cord-023095-4dannjjm 5654 6 nanoparticles nanoparticle NNS cord-023095-4dannjjm 5654 7 encapsulating encapsulate VBG cord-023095-4dannjjm 5654 8 doxorubicin doxorubicin NN cord-023095-4dannjjm 5654 9 to to TO cord-023095-4dannjjm 5654 10 exert exert VB cord-023095-4dannjjm 5654 11 in in IN cord-023095-4dannjjm 5654 12 vitro vitro FW cord-023095-4dannjjm 5654 13 cytotoxic cytotoxic JJ cord-023095-4dannjjm 5654 14 effects effect NNS cord-023095-4dannjjm 5654 15 in in IN cord-023095-4dannjjm 5654 16 cHSA chsa JJ cord-023095-4dannjjm 5654 17 cells cell NNS cord-023095-4dannjjm 5654 18 was be VBD cord-023095-4dannjjm 5654 19 assessed assess VBN cord-023095-4dannjjm 5654 20 by by IN cord-023095-4dannjjm 5654 21 colony colony NN cord-023095-4dannjjm 5654 22 forming form VBG cord-023095-4dannjjm 5654 23 assays assay NNS cord-023095-4dannjjm 5654 24 . . . cord-023095-4dannjjm 5655 1 Using use VBG cord-023095-4dannjjm 5655 2 a a DT cord-023095-4dannjjm 5655 3 cHSA chsa JJ cord-023095-4dannjjm 5655 4 xenograft xenograft NN cord-023095-4dannjjm 5655 5 murine murine JJ cord-023095-4dannjjm 5655 6 tumor tumor NN cord-023095-4dannjjm 5655 7 model model NN cord-023095-4dannjjm 5655 8 , , , cord-023095-4dannjjm 5655 9 clinically clinically RB cord-023095-4dannjjm 5655 10 - - HYPH cord-023095-4dannjjm 5655 11 relevant relevant JJ cord-023095-4dannjjm 5655 12 anticancer anticancer JJ cord-023095-4dannjjm 5655 13 effects effect NNS cord-023095-4dannjjm 5655 14 of of IN cord-023095-4dannjjm 5655 15 A10 A10 NNP cord-023095-4dannjjm 5655 16 decorated decorate VBN cord-023095-4dannjjm 5655 17 nanoparticles nanoparticle NNS cord-023095-4dannjjm 5655 18 encapsulating encapsulate VBG cord-023095-4dannjjm 5655 19 doxorubicin doxorubicin NN cord-023095-4dannjjm 5655 20 were be VBD cord-023095-4dannjjm 5655 21 tested test VBN cord-023095-4dannjjm 5655 22 . . . cord-023095-4dannjjm 5656 1 All all DT cord-023095-4dannjjm 5656 2 cHSA chsa JJ cord-023095-4dannjjm 5656 3 cell cell NN cord-023095-4dannjjm 5656 4 lines line NNS cord-023095-4dannjjm 5656 5 expressed express VBD cord-023095-4dannjjm 5656 6 PSMA PSMA NNP cord-023095-4dannjjm 5656 7 mRNA mRNA NNP cord-023095-4dannjjm 5656 8 and and CC cord-023095-4dannjjm 5656 9 protein protein NN cord-023095-4dannjjm 5656 10 . . . cord-023095-4dannjjm 5657 1 A10 A10 NNP cord-023095-4dannjjm 5657 2 decorated decorate VBN cord-023095-4dannjjm 5657 3 nanoparticles nanoparticle NNS cord-023095-4dannjjm 5657 4 were be VBD cord-023095-4dannjjm 5657 5 selectively selectively RB cord-023095-4dannjjm 5657 6 endocytosed endocytose VBN cord-023095-4dannjjm 5657 7 by by IN cord-023095-4dannjjm 5657 8 PSMA PSMA NNP cord-023095-4dannjjm 5657 9 - - HYPH cord-023095-4dannjjm 5657 10 expressing express VBG cord-023095-4dannjjm 5657 11 cells cell NNS cord-023095-4dannjjm 5657 12 , , , cord-023095-4dannjjm 5657 13 and and CC cord-023095-4dannjjm 5657 14 when when WRB cord-023095-4dannjjm 5657 15 these these DT cord-023095-4dannjjm 5657 16 nanoparticles nanoparticle NNS cord-023095-4dannjjm 5657 17 encapsulated encapsulate VBD cord-023095-4dannjjm 5657 18 doxorubicin doxorubicin JJ cord-023095-4dannjjm 5657 19 , , , cord-023095-4dannjjm 5657 20 significant significant JJ cord-023095-4dannjjm 5657 21 cytotoxic cytotoxic JJ cord-023095-4dannjjm 5657 22 effects effect NNS cord-023095-4dannjjm 5657 23 were be VBD cord-023095-4dannjjm 5657 24 exerted exert VBN cord-023095-4dannjjm 5657 25 in in IN cord-023095-4dannjjm 5657 26 vitro vitro FW cord-023095-4dannjjm 5657 27 . . . cord-023095-4dannjjm 5658 1 Finally finally RB cord-023095-4dannjjm 5658 2 , , , cord-023095-4dannjjm 5658 3 A10 A10 NNP cord-023095-4dannjjm 5658 4 decorated decorate VBD cord-023095-4dannjjm 5658 5 nanoparticles nanoparticle NNS cord-023095-4dannjjm 5658 6 encapsulating encapsulate VBG cord-023095-4dannjjm 5658 7 doxorubicin doxorubicin NN cord-023095-4dannjjm 5658 8 significantly significantly RB cord-023095-4dannjjm 5658 9 reduced reduce VBD cord-023095-4dannjjm 5658 10 the the DT cord-023095-4dannjjm 5658 11 size size NN cord-023095-4dannjjm 5658 12 of of IN cord-023095-4dannjjm 5658 13 macroscopic macroscopic JJ cord-023095-4dannjjm 5658 14 cHSA chsa JJ cord-023095-4dannjjm 5658 15 tumor tumor NN cord-023095-4dannjjm 5658 16 burdens burden NNS cord-023095-4dannjjm 5658 17 in in IN cord-023095-4dannjjm 5658 18 transplanted transplanted JJ cord-023095-4dannjjm 5658 19 mice mouse NNS cord-023095-4dannjjm 5658 20 . . . cord-023095-4dannjjm 5659 1 Diagnostic diagnostic JJ cord-023095-4dannjjm 5659 2 and and CC cord-023095-4dannjjm 5659 3 therapeutic therapeutic JJ cord-023095-4dannjjm 5659 4 nanoparticles nanoparticle NNS cord-023095-4dannjjm 5659 5 can can MD cord-023095-4dannjjm 5659 6 be be VB cord-023095-4dannjjm 5659 7 targeted target VBN cord-023095-4dannjjm 5659 8 to to IN cord-023095-4dannjjm 5659 9 PSMA PSMA NNP cord-023095-4dannjjm 5659 10 - - : cord-023095-4dannjjm 5659 11 expressing express VBG cord-023095-4dannjjm 5659 12 endothelial endothelial JJ cord-023095-4dannjjm 5659 13 cells cell NNS cord-023095-4dannjjm 5659 14 , , , cord-023095-4dannjjm 5659 15 and and CC cord-023095-4dannjjm 5659 16 cHSA cHSA NNP cord-023095-4dannjjm 5659 17 provides provide VBZ cord-023095-4dannjjm 5659 18 a a DT cord-023095-4dannjjm 5659 19 comparative comparative JJ cord-023095-4dannjjm 5659 20 model model NN cord-023095-4dannjjm 5659 21 for for IN cord-023095-4dannjjm 5659 22 the the DT cord-023095-4dannjjm 5659 23 future future JJ cord-023095-4dannjjm 5659 24 study study NN cord-023095-4dannjjm 5659 25 of of IN cord-023095-4dannjjm 5659 26 nanoparticle nanoparticle NN cord-023095-4dannjjm 5659 27 therapeutics therapeutic NNS cord-023095-4dannjjm 5659 28 . . . cord-023095-4dannjjm 5660 1 Canine canine JJ cord-023095-4dannjjm 5660 2 transitional transitional JJ cord-023095-4dannjjm 5660 3 cell cell NN cord-023095-4dannjjm 5660 4 carcinoma carcinoma NN cord-023095-4dannjjm 5660 5 ( ( -LRB- cord-023095-4dannjjm 5660 6 TCC TCC NNP cord-023095-4dannjjm 5660 7 ) ) -RRB- cord-023095-4dannjjm 5660 8 is be VBZ cord-023095-4dannjjm 5660 9 the the DT cord-023095-4dannjjm 5660 10 most most RBS cord-023095-4dannjjm 5660 11 common common JJ cord-023095-4dannjjm 5660 12 tumor tumor NN cord-023095-4dannjjm 5660 13 of of IN cord-023095-4dannjjm 5660 14 the the DT cord-023095-4dannjjm 5660 15 urinary urinary JJ cord-023095-4dannjjm 5660 16 tract tract NN cord-023095-4dannjjm 5660 17 , , , cord-023095-4dannjjm 5660 18 and and CC cord-023095-4dannjjm 5660 19 is be VBZ cord-023095-4dannjjm 5660 20 similar similar JJ cord-023095-4dannjjm 5660 21 to to IN cord-023095-4dannjjm 5660 22 human human JJ cord-023095-4dannjjm 5660 23 invasive invasive JJ cord-023095-4dannjjm 5660 24 TCC tcc NN cord-023095-4dannjjm 5660 25 in in IN cord-023095-4dannjjm 5660 26 histopathologic histopathologic JJ cord-023095-4dannjjm 5660 27 characteristics characteristic NNS cord-023095-4dannjjm 5660 28 , , , cord-023095-4dannjjm 5660 29 molecular molecular JJ cord-023095-4dannjjm 5660 30 features feature NNS cord-023095-4dannjjm 5660 31 , , , cord-023095-4dannjjm 5660 32 sites site NNS cord-023095-4dannjjm 5660 33 of of IN cord-023095-4dannjjm 5660 34 metastasis metastasis NN cord-023095-4dannjjm 5660 35 , , , cord-023095-4dannjjm 5660 36 and and CC cord-023095-4dannjjm 5660 37 response response NN cord-023095-4dannjjm 5660 38 to to IN cord-023095-4dannjjm 5660 39 medical medical JJ cord-023095-4dannjjm 5660 40 therapy therapy NN cord-023095-4dannjjm 5660 41 . . . cord-023095-4dannjjm 5661 1 Prevalence prevalence NN cord-023095-4dannjjm 5661 2 is be VBZ cord-023095-4dannjjm 5661 3 increasing increase VBG cord-023095-4dannjjm 5661 4 , , , cord-023095-4dannjjm 5661 5 and and CC cord-023095-4dannjjm 5661 6 novel novel JJ cord-023095-4dannjjm 5661 7 therapies therapy NNS cord-023095-4dannjjm 5661 8 and and CC cord-023095-4dannjjm 5661 9 strategies strategy NNS cord-023095-4dannjjm 5661 10 are be VBP cord-023095-4dannjjm 5661 11 needed need VBN cord-023095-4dannjjm 5661 12 to to TO cord-023095-4dannjjm 5661 13 effectively effectively RB cord-023095-4dannjjm 5661 14 treat treat VB cord-023095-4dannjjm 5661 15 this this DT cord-023095-4dannjjm 5661 16 aggressive aggressive JJ cord-023095-4dannjjm 5661 17 form form NN cord-023095-4dannjjm 5661 18 of of IN cord-023095-4dannjjm 5661 19 cancer cancer NN cord-023095-4dannjjm 5661 20 in in IN cord-023095-4dannjjm 5661 21 both both DT cord-023095-4dannjjm 5661 22 species specie NNS cord-023095-4dannjjm 5661 23 . . . cord-023095-4dannjjm 5662 1 Personalized personalized JJ cord-023095-4dannjjm 5662 2 medicine medicine NN cord-023095-4dannjjm 5662 3 techniques technique NNS cord-023095-4dannjjm 5662 4 intend intend VBP cord-023095-4dannjjm 5662 5 to to TO cord-023095-4dannjjm 5662 6 improve improve VB cord-023095-4dannjjm 5662 7 treatment treatment NN cord-023095-4dannjjm 5662 8 outcome outcome NN cord-023095-4dannjjm 5662 9 by by IN cord-023095-4dannjjm 5662 10 using use VBG cord-023095-4dannjjm 5662 11 patient patient JJ cord-023095-4dannjjm 5662 12 tumor tumor NN cord-023095-4dannjjm 5662 13 profiling profiling NN cord-023095-4dannjjm 5662 14 to to TO cord-023095-4dannjjm 5662 15 identify identify VB cord-023095-4dannjjm 5662 16 potential potential JJ cord-023095-4dannjjm 5662 17 and and CC cord-023095-4dannjjm 5662 18 individualized individualized JJ cord-023095-4dannjjm 5662 19 therapeutic therapeutic JJ cord-023095-4dannjjm 5662 20 targets target NNS cord-023095-4dannjjm 5662 21 . . . cord-023095-4dannjjm 5663 1 A a DT cord-023095-4dannjjm 5663 2 genomic genomic JJ cord-023095-4dannjjm 5663 3 algorithm algorithm NN cord-023095-4dannjjm 5663 4 has have VBZ cord-023095-4dannjjm 5663 5 been be VBN cord-023095-4dannjjm 5663 6 developed develop VBN cord-023095-4dannjjm 5663 7 termed term VBN cord-023095-4dannjjm 5663 8 ' ' '' cord-023095-4dannjjm 5663 9 ' ' `` cord-023095-4dannjjm 5663 10 coexpression coexpression NN cord-023095-4dannjjm 5663 11 extrapolation extrapolation NN cord-023095-4dannjjm 5663 12 ' ' '' cord-023095-4dannjjm 5663 13 ' ' '' cord-023095-4dannjjm 5663 14 , , , cord-023095-4dannjjm 5663 15 or or CC cord-023095-4dannjjm 5663 16 COXEN COXEN NNP cord-023095-4dannjjm 5663 17 , , , cord-023095-4dannjjm 5663 18 that that WDT cord-023095-4dannjjm 5663 19 aims aim VBZ cord-023095-4dannjjm 5663 20 to to TO cord-023095-4dannjjm 5663 21 use use VB cord-023095-4dannjjm 5663 22 expression expression NN cord-023095-4dannjjm 5663 23 microarray microarray NN cord-023095-4dannjjm 5663 24 data datum NNS cord-023095-4dannjjm 5663 25 to to TO cord-023095-4dannjjm 5663 26 predict predict VB cord-023095-4dannjjm 5663 27 drug drug NN cord-023095-4dannjjm 5663 28 activity activity NN cord-023095-4dannjjm 5663 29 in in IN cord-023095-4dannjjm 5663 30 patient patient JJ cord-023095-4dannjjm 5663 31 TCC tcc NN cord-023095-4dannjjm 5663 32 samples sample NNS cord-023095-4dannjjm 5663 33 . . . cord-023095-4dannjjm 5664 1 The the DT cord-023095-4dannjjm 5664 2 utility utility NN cord-023095-4dannjjm 5664 3 of of IN cord-023095-4dannjjm 5664 4 this this DT cord-023095-4dannjjm 5664 5 predictive predictive JJ cord-023095-4dannjjm 5664 6 methodology methodology NN cord-023095-4dannjjm 5664 7 has have VBZ cord-023095-4dannjjm 5664 8 been be VBN cord-023095-4dannjjm 5664 9 established establish VBN cord-023095-4dannjjm 5664 10 in in IN cord-023095-4dannjjm 5664 11 other other JJ cord-023095-4dannjjm 5664 12 types type NNS cord-023095-4dannjjm 5664 13 of of IN cord-023095-4dannjjm 5664 14 cancer cancer NN cord-023095-4dannjjm 5664 15 in in IN cord-023095-4dannjjm 5664 16 vitro vitro FW cord-023095-4dannjjm 5664 17 , , , cord-023095-4dannjjm 5664 18 however however RB cord-023095-4dannjjm 5664 19 its -PRON- PRP$ cord-023095-4dannjjm 5664 20 clinical clinical JJ cord-023095-4dannjjm 5664 21 utility utility NN cord-023095-4dannjjm 5664 22 has have VBZ cord-023095-4dannjjm 5664 23 not not RB cord-023095-4dannjjm 5664 24 yet yet RB cord-023095-4dannjjm 5664 25 been be VBN cord-023095-4dannjjm 5664 26 determined determine VBN cord-023095-4dannjjm 5664 27 . . . cord-023095-4dannjjm 5665 1 Validation validation NN cord-023095-4dannjjm 5665 2 studies study NNS cord-023095-4dannjjm 5665 3 of of IN cord-023095-4dannjjm 5665 4 COXEN COXEN NNP cord-023095-4dannjjm 5665 5 in in IN cord-023095-4dannjjm 5665 6 10 10 CD cord-023095-4dannjjm 5665 7 canine canine JJ cord-023095-4dannjjm 5665 8 TCC tcc NN cord-023095-4dannjjm 5665 9 cell cell NN cord-023095-4dannjjm 5665 10 lines line NNS cord-023095-4dannjjm 5665 11 were be VBD cord-023095-4dannjjm 5665 12 conducted conduct VBN cord-023095-4dannjjm 5665 13 . . . cord-023095-4dannjjm 5666 1 The the DT cord-023095-4dannjjm 5666 2 goal goal NN cord-023095-4dannjjm 5666 3 was be VBD cord-023095-4dannjjm 5666 4 to to TO cord-023095-4dannjjm 5666 5 determine determine VB cord-023095-4dannjjm 5666 6 the the DT cord-023095-4dannjjm 5666 7 value value NN cord-023095-4dannjjm 5666 8 of of IN cord-023095-4dannjjm 5666 9 COXEN COXEN NNP cord-023095-4dannjjm 5666 10 in in IN cord-023095-4dannjjm 5666 11 predicting predict VBG cord-023095-4dannjjm 5666 12 baseline baseline JJ cord-023095-4dannjjm 5666 13 sensitivity sensitivity NN cord-023095-4dannjjm 5666 14 of of IN cord-023095-4dannjjm 5666 15 canine canine JJ cord-023095-4dannjjm 5666 16 TCC tcc NN cord-023095-4dannjjm 5666 17 to to IN cord-023095-4dannjjm 5666 18 5 5 CD cord-023095-4dannjjm 5666 19 chemotherapy chemotherapy NN cord-023095-4dannjjm 5666 20 agents agent NNS cord-023095-4dannjjm 5666 21 ( ( -LRB- cord-023095-4dannjjm 5666 22 gemcitabine gemcitabine NNP cord-023095-4dannjjm 5666 23 , , , cord-023095-4dannjjm 5666 24 mitoxantrone mitoxantrone NNP cord-023095-4dannjjm 5666 25 , , , cord-023095-4dannjjm 5666 26 carboplatin carboplatin NNP cord-023095-4dannjjm 5666 27 , , , cord-023095-4dannjjm 5666 28 vinblastine vinblastine NN cord-023095-4dannjjm 5666 29 and and CC cord-023095-4dannjjm 5666 30 cisplatin cisplatin NN cord-023095-4dannjjm 5666 31 ) ) -RRB- cord-023095-4dannjjm 5666 32 that that WDT cord-023095-4dannjjm 5666 33 would would MD cord-023095-4dannjjm 5666 34 then then RB cord-023095-4dannjjm 5666 35 be be VB cord-023095-4dannjjm 5666 36 used use VBN cord-023095-4dannjjm 5666 37 in in IN cord-023095-4dannjjm 5666 38 a a DT cord-023095-4dannjjm 5666 39 proposed propose VBN cord-023095-4dannjjm 5666 40 clinical clinical JJ cord-023095-4dannjjm 5666 41 trial trial NN cord-023095-4dannjjm 5666 42 . . . cord-023095-4dannjjm 5667 1 Additionally additionally RB cord-023095-4dannjjm 5667 2 , , , cord-023095-4dannjjm 5667 3 expression expression NN cord-023095-4dannjjm 5667 4 data datum NNS cord-023095-4dannjjm 5667 5 from from IN cord-023095-4dannjjm 5667 6 25 25 CD cord-023095-4dannjjm 5667 7 canine canine JJ cord-023095-4dannjjm 5667 8 treatment treatment NN cord-023095-4dannjjm 5667 9 - - HYPH cord-023095-4dannjjm 5667 10 naı¨ve naı¨ve NN cord-023095-4dannjjm 5667 11 primary primary JJ cord-023095-4dannjjm 5667 12 tumor tumor NN cord-023095-4dannjjm 5667 13 samples sample NNS cord-023095-4dannjjm 5667 14 were be VBD cord-023095-4dannjjm 5667 15 generated generate VBN cord-023095-4dannjjm 5667 16 on on IN cord-023095-4dannjjm 5667 17 an an DT cord-023095-4dannjjm 5667 18 Affymetrix Affymetrix NNP cord-023095-4dannjjm 5667 19 array array NN cord-023095-4dannjjm 5667 20 platform platform NN cord-023095-4dannjjm 5667 21 ( ( -LRB- cord-023095-4dannjjm 5667 22 Canine Canine NNP cord-023095-4dannjjm 5667 23 Genome Genome NNP cord-023095-4dannjjm 5667 24 v v NN cord-023095-4dannjjm 5667 25 2.0 2.0 CD cord-023095-4dannjjm 5667 26 ) ) -RRB- cord-023095-4dannjjm 5667 27 . . . cord-023095-4dannjjm 5668 1 Both both DT cord-023095-4dannjjm 5668 2 the the DT cord-023095-4dannjjm 5668 3 expression expression NN cord-023095-4dannjjm 5668 4 data datum NNS cord-023095-4dannjjm 5668 5 and and CC cord-023095-4dannjjm 5668 6 TCC TCC NNP cord-023095-4dannjjm 5668 7 cell cell NN cord-023095-4dannjjm 5668 8 line line NN cord-023095-4dannjjm 5668 9 data datum NNS cord-023095-4dannjjm 5668 10 ( ( -LRB- cord-023095-4dannjjm 5668 11 antiproliferative antiproliferative JJ cord-023095-4dannjjm 5668 12 effects effect NNS cord-023095-4dannjjm 5668 13 , , , cord-023095-4dannjjm 5668 14 50 50 CD cord-023095-4dannjjm 5668 15 % % NN cord-023095-4dannjjm 5668 16 growth growth NN cord-023095-4dannjjm 5668 17 inhibition inhibition NN cord-023095-4dannjjm 5668 18 or or CC cord-023095-4dannjjm 5668 19 GC GC NNP cord-023095-4dannjjm 5668 20 50 50 CD cord-023095-4dannjjm 5668 21 ) ) -RRB- cord-023095-4dannjjm 5668 22 were be VBD cord-023095-4dannjjm 5668 23 used use VBN cord-023095-4dannjjm 5668 24 to to TO cord-023095-4dannjjm 5668 25 establish establish VB cord-023095-4dannjjm 5668 26 a a DT cord-023095-4dannjjm 5668 27 canine canine JJ cord-023095-4dannjjm 5668 28 specific specific JJ cord-023095-4dannjjm 5668 29 predictive predictive JJ cord-023095-4dannjjm 5668 30 COXEN coxen NN cord-023095-4dannjjm 5668 31 algorithm algorithm NN cord-023095-4dannjjm 5668 32 . . . cord-023095-4dannjjm 5669 1 COXEN COXEN NNP cord-023095-4dannjjm 5669 2 scores score NNS cord-023095-4dannjjm 5669 3 for for IN cord-023095-4dannjjm 5669 4 canine canine JJ cord-023095-4dannjjm 5669 5 TCC TCC NNP cord-023095-4dannjjm 5669 6 cell cell NN cord-023095-4dannjjm 5669 7 - - HYPH cord-023095-4dannjjm 5669 8 line line NN cord-023095-4dannjjm 5669 9 drug drug NN cord-023095-4dannjjm 5669 10 activity activity NN cord-023095-4dannjjm 5669 11 were be VBD cord-023095-4dannjjm 5669 12 then then RB cord-023095-4dannjjm 5669 13 analyzed analyze VBN cord-023095-4dannjjm 5669 14 . . . cord-023095-4dannjjm 5670 1 Scores score NNS cord-023095-4dannjjm 5670 2 predicted predict VBD cord-023095-4dannjjm 5670 3 the the DT cord-023095-4dannjjm 5670 4 activity activity NN cord-023095-4dannjjm 5670 5 of of IN cord-023095-4dannjjm 5670 6 cisplatin cisplatin NN cord-023095-4dannjjm 5670 7 , , , cord-023095-4dannjjm 5670 8 gemcitibine gemcitibine NNP cord-023095-4dannjjm 5670 9 , , , cord-023095-4dannjjm 5670 10 and and CC cord-023095-4dannjjm 5670 11 mitoxantrone mitoxantrone VBN cord-023095-4dannjjm 5670 12 in in IN cord-023095-4dannjjm 5670 13 all all DT cord-023095-4dannjjm 5670 14 10 10 CD cord-023095-4dannjjm 5670 15 cell cell NN cord-023095-4dannjjm 5670 16 lines line NNS cord-023095-4dannjjm 5670 17 , , , cord-023095-4dannjjm 5670 18 and and CC cord-023095-4dannjjm 5670 19 of of IN cord-023095-4dannjjm 5670 20 carboplatin carboplatin NNS cord-023095-4dannjjm 5670 21 in in IN cord-023095-4dannjjm 5670 22 6 6 CD cord-023095-4dannjjm 5670 23 cell cell NN cord-023095-4dannjjm 5670 24 lines line NNS cord-023095-4dannjjm 5670 25 . . . cord-023095-4dannjjm 5671 1 Because because IN cord-023095-4dannjjm 5671 2 all all DT cord-023095-4dannjjm 5671 3 of of IN cord-023095-4dannjjm 5671 4 the the DT cord-023095-4dannjjm 5671 5 cell cell NN cord-023095-4dannjjm 5671 6 lines line NNS cord-023095-4dannjjm 5671 7 were be VBD cord-023095-4dannjjm 5671 8 sensitive sensitive JJ cord-023095-4dannjjm 5671 9 to to IN cord-023095-4dannjjm 5671 10 vinblastine vinblastine NN cord-023095-4dannjjm 5671 11 ( ( -LRB- cord-023095-4dannjjm 5671 12 GI GI NNP cord-023095-4dannjjm 5671 13 50 50 CD cord-023095-4dannjjm 5671 14 o0.05 o0.05 NN cord-023095-4dannjjm 5671 15 mM mm NN cord-023095-4dannjjm 5671 16 ) ) -RRB- cord-023095-4dannjjm 5671 17 , , , cord-023095-4dannjjm 5671 18 the the DT cord-023095-4dannjjm 5671 19 COXEN COXEN NNP cord-023095-4dannjjm 5671 20 score score NN cord-023095-4dannjjm 5671 21 was be VBD cord-023095-4dannjjm 5671 22 not not RB cord-023095-4dannjjm 5671 23 predictive predictive JJ cord-023095-4dannjjm 5671 24 of of IN cord-023095-4dannjjm 5671 25 its -PRON- PRP$ cord-023095-4dannjjm 5671 26 potency potency NN cord-023095-4dannjjm 5671 27 . . . cord-023095-4dannjjm 5672 1 Interestingly interestingly RB cord-023095-4dannjjm 5672 2 , , , cord-023095-4dannjjm 5672 3 COXEN COXEN NNP cord-023095-4dannjjm 5672 4 fails fail VBZ cord-023095-4dannjjm 5672 5 to to TO cord-023095-4dannjjm 5672 6 predict predict VB cord-023095-4dannjjm 5672 7 vinblastine vinblastine NN cord-023095-4dannjjm 5672 8 response response NN cord-023095-4dannjjm 5672 9 in in IN cord-023095-4dannjjm 5672 10 human human JJ cord-023095-4dannjjm 5672 11 TCC TCC NNP cord-023095-4dannjjm 5672 12 cell cell NN cord-023095-4dannjjm 5672 13 line line NN cord-023095-4dannjjm 5672 14 data datum NNS cord-023095-4dannjjm 5672 15 as as RB cord-023095-4dannjjm 5672 16 well well RB cord-023095-4dannjjm 5672 17 . . . cord-023095-4dannjjm 5673 1 In in IN cord-023095-4dannjjm 5673 2 concurrent concurrent JJ cord-023095-4dannjjm 5673 3 work work NN cord-023095-4dannjjm 5673 4 , , , cord-023095-4dannjjm 5673 5 comparative comparative JJ cord-023095-4dannjjm 5673 6 genomic genomic JJ cord-023095-4dannjjm 5673 7 studies study NNS cord-023095-4dannjjm 5673 8 to to TO cord-023095-4dannjjm 5673 9 define define VB cord-023095-4dannjjm 5673 10 and and CC cord-023095-4dannjjm 5673 11 compare compare VB cord-023095-4dannjjm 5673 12 the the DT cord-023095-4dannjjm 5673 13 gene gene NN cord-023095-4dannjjm 5673 14 expression expression NN cord-023095-4dannjjm 5673 15 signatures signature NNS cord-023095-4dannjjm 5673 16 of of IN cord-023095-4dannjjm 5673 17 TCC tcc NN cord-023095-4dannjjm 5673 18 in in IN cord-023095-4dannjjm 5673 19 dogs dog NNS cord-023095-4dannjjm 5673 20 and and CC cord-023095-4dannjjm 5673 21 humans human NNS cord-023095-4dannjjm 5673 22 provides provide VBZ cord-023095-4dannjjm 5673 23 further further JJ cord-023095-4dannjjm 5673 24 evidence evidence NN cord-023095-4dannjjm 5673 25 that that IN cord-023095-4dannjjm 5673 26 canine canine JJ cord-023095-4dannjjm 5673 27 TCC tcc NN cord-023095-4dannjjm 5673 28 is be VBZ cord-023095-4dannjjm 5673 29 a a DT cord-023095-4dannjjm 5673 30 valuable valuable JJ cord-023095-4dannjjm 5673 31 genomic genomic JJ cord-023095-4dannjjm 5673 32 model model NN cord-023095-4dannjjm 5673 33 of of IN cord-023095-4dannjjm 5673 34 the the DT cord-023095-4dannjjm 5673 35 human human JJ cord-023095-4dannjjm 5673 36 disease disease NN cord-023095-4dannjjm 5673 37 . . . cord-023095-4dannjjm 5674 1 Current current JJ cord-023095-4dannjjm 5674 2 studies study NNS cord-023095-4dannjjm 5674 3 involve involve VBP cord-023095-4dannjjm 5674 4 testing test VBG cord-023095-4dannjjm 5674 5 the the DT cord-023095-4dannjjm 5674 6 chemo chemo NN cord-023095-4dannjjm 5674 7 - - HYPH cord-023095-4dannjjm 5674 8 predictivity predictivity NN cord-023095-4dannjjm 5674 9 of of IN cord-023095-4dannjjm 5674 10 this this DT cord-023095-4dannjjm 5674 11 derived derive VBN cord-023095-4dannjjm 5674 12 canine canine JJ cord-023095-4dannjjm 5674 13 COXEN coxen NN cord-023095-4dannjjm 5674 14 algorithm algorithm NN cord-023095-4dannjjm 5674 15 in in IN cord-023095-4dannjjm 5674 16 additional additional JJ cord-023095-4dannjjm 5674 17 canine canine JJ cord-023095-4dannjjm 5674 18 TCC tcc NN cord-023095-4dannjjm 5674 19 cell cell NN cord-023095-4dannjjm 5674 20 lines line NNS cord-023095-4dannjjm 5674 21 . . . cord-023095-4dannjjm 5675 1 Canine canine JJ cord-023095-4dannjjm 5675 2 TCC TCC NNP cord-023095-4dannjjm 5675 3 offers offer VBZ cord-023095-4dannjjm 5675 4 an an DT cord-023095-4dannjjm 5675 5 excellent excellent JJ cord-023095-4dannjjm 5675 6 model model NN cord-023095-4dannjjm 5675 7 for for IN cord-023095-4dannjjm 5675 8 in in IN cord-023095-4dannjjm 5675 9 vitro vitro FW cord-023095-4dannjjm 5675 10 and and CC cord-023095-4dannjjm 5675 11 in in IN cord-023095-4dannjjm 5675 12 vivo vivo NNP cord-023095-4dannjjm 5675 13 studies study NNS cord-023095-4dannjjm 5675 14 of of IN cord-023095-4dannjjm 5675 15 the the DT cord-023095-4dannjjm 5675 16 COXEN COXEN NNP cord-023095-4dannjjm 5675 17 approach approach NN cord-023095-4dannjjm 5675 18 . . . cord-023095-4dannjjm 5676 1 This this DT cord-023095-4dannjjm 5676 2 preclinical preclinical JJ cord-023095-4dannjjm 5676 3 work work NN cord-023095-4dannjjm 5676 4 will will MD cord-023095-4dannjjm 5676 5 be be VB cord-023095-4dannjjm 5676 6 used use VBN cord-023095-4dannjjm 5676 7 to to TO cord-023095-4dannjjm 5676 8 guide guide VB cord-023095-4dannjjm 5676 9 the the DT cord-023095-4dannjjm 5676 10 feasibility feasibility NN cord-023095-4dannjjm 5676 11 of of IN cord-023095-4dannjjm 5676 12 future future JJ cord-023095-4dannjjm 5676 13 COXEN coxen NN cord-023095-4dannjjm 5676 14 clinical clinical JJ cord-023095-4dannjjm 5676 15 trials trial NNS cord-023095-4dannjjm 5676 16 in in IN cord-023095-4dannjjm 5676 17 dogs dog NNS cord-023095-4dannjjm 5676 18 and and CC cord-023095-4dannjjm 5676 19 humans human NNS cord-023095-4dannjjm 5676 20 with with IN cord-023095-4dannjjm 5676 21 TCC TCC NNP cord-023095-4dannjjm 5676 22 . . . cord-023095-4dannjjm 5677 1 A a DT cord-023095-4dannjjm 5677 2 small small JJ cord-023095-4dannjjm 5677 3 molecule molecule NN cord-023095-4dannjjm 5677 4 complex complex NN cord-023095-4dannjjm 5677 5 ( ( -LRB- cord-023095-4dannjjm 5677 6 Aminoact Aminoact NNP cord-023095-4dannjjm 5677 7 ) ) -RRB- cord-023095-4dannjjm 5677 8 isolated isolate VBN cord-023095-4dannjjm 5677 9 from from IN cord-023095-4dannjjm 5677 10 bovine bovine JJ cord-023095-4dannjjm 5677 11 milk milk NN cord-023095-4dannjjm 5677 12 is be VBZ cord-023095-4dannjjm 5677 13 a a DT cord-023095-4dannjjm 5677 14 natural natural JJ cord-023095-4dannjjm 5677 15 peptide peptide NN cord-023095-4dannjjm 5677 16 mixture mixture NN cord-023095-4dannjjm 5677 17 with with IN cord-023095-4dannjjm 5677 18 multi multi JJ cord-023095-4dannjjm 5677 19 - - JJ cord-023095-4dannjjm 5677 20 kinase kinase JJ cord-023095-4dannjjm 5677 21 inhibitory inhibitory JJ cord-023095-4dannjjm 5677 22 effects effect NNS cord-023095-4dannjjm 5677 23 against against IN cord-023095-4dannjjm 5677 24 epidermal epidermal JJ cord-023095-4dannjjm 5677 25 growth growth NN cord-023095-4dannjjm 5677 26 factor factor NN cord-023095-4dannjjm 5677 27 receptor receptor NN cord-023095-4dannjjm 5677 28 ( ( -LRB- cord-023095-4dannjjm 5677 29 EGFR EGFR NNP cord-023095-4dannjjm 5677 30 ) ) -RRB- cord-023095-4dannjjm 5677 31 and and CC cord-023095-4dannjjm 5677 32 insulin insulin NN cord-023095-4dannjjm 5677 33 - - HYPH cord-023095-4dannjjm 5677 34 like like JJ cord-023095-4dannjjm 5677 35 growth growth NN cord-023095-4dannjjm 5677 36 factor factor NN cord-023095-4dannjjm 5678 1 receptor-1 receptor-1 NNP cord-023095-4dannjjm 5679 1 ( ( -LRB- cord-023095-4dannjjm 5679 2 IGFR-1 IGFR-1 NNP cord-023095-4dannjjm 5679 3 ) ) -RRB- cord-023095-4dannjjm 5679 4 . . . cord-023095-4dannjjm 5680 1 Ingestion ingestion NN cord-023095-4dannjjm 5680 2 of of IN cord-023095-4dannjjm 5680 3 Aminoact Aminoact NNP cord-023095-4dannjjm 5680 4 in in IN cord-023095-4dannjjm 5680 5 people people NNS cord-023095-4dannjjm 5680 6 with with IN cord-023095-4dannjjm 5680 7 cancer cancer NN cord-023095-4dannjjm 5680 8 results result NNS cord-023095-4dannjjm 5680 9 in in IN cord-023095-4dannjjm 5680 10 lower low JJR cord-023095-4dannjjm 5680 11 serum serum NN cord-023095-4dannjjm 5680 12 TNF tnf NN cord-023095-4dannjjm 5680 13 - - HYPH cord-023095-4dannjjm 5680 14 alpha alpha NN cord-023095-4dannjjm 5680 15 , , , cord-023095-4dannjjm 5680 16 an an DT cord-023095-4dannjjm 5680 17 increase increase NN cord-023095-4dannjjm 5680 18 in in IN cord-023095-4dannjjm 5680 19 antioxidant antioxidant JJ cord-023095-4dannjjm 5680 20 superoxide superoxide NN cord-023095-4dannjjm 5680 21 dismutase dismutase NN cord-023095-4dannjjm 5680 22 ( ( -LRB- cord-023095-4dannjjm 5680 23 SOD SOD NNP cord-023095-4dannjjm 5680 24 ) ) -RRB- cord-023095-4dannjjm 5680 25 enzyme enzyme NN cord-023095-4dannjjm 5680 26 activity activity NN cord-023095-4dannjjm 5680 27 , , , cord-023095-4dannjjm 5680 28 and and CC cord-023095-4dannjjm 5680 29 subjects subject NNS cord-023095-4dannjjm 5680 30 ' ' POS cord-023095-4dannjjm 5680 31 blood blood NN cord-023095-4dannjjm 5680 32 serum serum NN cord-023095-4dannjjm 5680 33 causes cause VBZ cord-023095-4dannjjm 5680 34 apopsotis apopsotis JJ cord-023095-4dannjjm 5680 35 in in IN cord-023095-4dannjjm 5680 36 cancer cancer NN cord-023095-4dannjjm 5680 37 cell cell NN cord-023095-4dannjjm 5680 38 lines line NNS cord-023095-4dannjjm 5680 39 . . . cord-023095-4dannjjm 5681 1 This this DT cord-023095-4dannjjm 5681 2 study study NN cord-023095-4dannjjm 5681 3 was be VBD cord-023095-4dannjjm 5681 4 designed design VBN cord-023095-4dannjjm 5681 5 to to TO cord-023095-4dannjjm 5681 6 first first RB cord-023095-4dannjjm 5681 7 assess assess VB cord-023095-4dannjjm 5681 8 safety safety NN cord-023095-4dannjjm 5681 9 and and CC cord-023095-4dannjjm 5681 10 secondly secondly RB cord-023095-4dannjjm 5681 11 the the DT cord-023095-4dannjjm 5681 12 efficacy efficacy NN cord-023095-4dannjjm 5681 13 of of IN cord-023095-4dannjjm 5681 14 three three CD cord-023095-4dannjjm 5681 15 dosage dosage NN cord-023095-4dannjjm 5681 16 levels level NNS cord-023095-4dannjjm 5681 17 of of IN cord-023095-4dannjjm 5681 18 AX-3 AX-3 NNP cord-023095-4dannjjm 5681 19 in in IN cord-023095-4dannjjm 5681 20 sustaining sustain VBG cord-023095-4dannjjm 5681 21 progression progression NN cord-023095-4dannjjm 5681 22 free free JJ cord-023095-4dannjjm 5681 23 survival survival NN cord-023095-4dannjjm 5681 24 ( ( -LRB- cord-023095-4dannjjm 5681 25 PFS PFS NNP cord-023095-4dannjjm 5681 26 ) ) -RRB- cord-023095-4dannjjm 5681 27 for for IN cord-023095-4dannjjm 5681 28 dogs dog NNS cord-023095-4dannjjm 5681 29 with with IN cord-023095-4dannjjm 5681 30 refractory refractory JJ cord-023095-4dannjjm 5681 31 advanced advanced JJ cord-023095-4dannjjm 5681 32 and/or and/or CC cord-023095-4dannjjm 5681 33 metastatic metastatic JJ cord-023095-4dannjjm 5681 34 cancer cancer NN cord-023095-4dannjjm 5681 35 . . . cord-023095-4dannjjm 5682 1 The the DT cord-023095-4dannjjm 5682 2 prospective prospective JJ cord-023095-4dannjjm 5682 3 , , , cord-023095-4dannjjm 5682 4 open open JJ cord-023095-4dannjjm 5682 5 label label NN cord-023095-4dannjjm 5682 6 study study NN cord-023095-4dannjjm 5682 7 included include VBD cord-023095-4dannjjm 5682 8 dogs dog NNS cord-023095-4dannjjm 5682 9 of of IN cord-023095-4dannjjm 5682 10 different different JJ cord-023095-4dannjjm 5682 11 breeds breed NNS cord-023095-4dannjjm 5682 12 with with IN cord-023095-4dannjjm 5682 13 naturally naturally RB cord-023095-4dannjjm 5682 14 occurring occur VBG cord-023095-4dannjjm 5682 15 histologically histologically RB cord-023095-4dannjjm 5682 16 confirmed confirm VBD cord-023095-4dannjjm 5682 17 malignancies malignancy NNS cord-023095-4dannjjm 5682 18 . . . cord-023095-4dannjjm 5683 1 The the DT cord-023095-4dannjjm 5683 2 first first JJ cord-023095-4dannjjm 5683 3 13 13 CD cord-023095-4dannjjm 5683 4 dogs dog NNS cord-023095-4dannjjm 5683 5 received receive VBD cord-023095-4dannjjm 5683 6 Aminoact Aminoact NNP cord-023095-4dannjjm 5683 7 at at IN cord-023095-4dannjjm 5683 8 1g 1g CD cord-023095-4dannjjm 5683 9 / / SYM cord-023095-4dannjjm 5683 10 m m NN cord-023095-4dannjjm 5683 11 2 2 CD cord-023095-4dannjjm 5683 12 ; ; : cord-023095-4dannjjm 5683 13 the the DT cord-023095-4dannjjm 5683 14 second second JJ cord-023095-4dannjjm 5683 15 group group NN cord-023095-4dannjjm 5683 16 of of IN cord-023095-4dannjjm 5683 17 7 7 CD cord-023095-4dannjjm 5683 18 dogs dog NNS cord-023095-4dannjjm 5683 19 subsequently subsequently RB cord-023095-4dannjjm 5683 20 received receive VBD cord-023095-4dannjjm 5683 21 the the DT cord-023095-4dannjjm 5683 22 same same JJ cord-023095-4dannjjm 5683 23 dosage dosage NN cord-023095-4dannjjm 5683 24 1 1 CD cord-023095-4dannjjm 5683 25 350 350 CD cord-023095-4dannjjm 5683 26 mg mg NN cord-023095-4dannjjm 5683 27 of of IN cord-023095-4dannjjm 5683 28 Aminoact Aminoact NNP cord-023095-4dannjjm 5683 29 ; ; : cord-023095-4dannjjm 5683 30 and and CC cord-023095-4dannjjm 5683 31 the the DT cord-023095-4dannjjm 5683 32 third third JJ cord-023095-4dannjjm 5683 33 group group NN cord-023095-4dannjjm 5683 34 of of IN cord-023095-4dannjjm 5683 35 dogs dog NNS cord-023095-4dannjjm 5683 36 subsequently subsequently RB cord-023095-4dannjjm 5683 37 received receive VBD cord-023095-4dannjjm 5683 38 2g/ 2g/ CD cord-023095-4dannjjm 5683 39 m m CD cord-023095-4dannjjm 5683 40 2 2 CD cord-023095-4dannjjm 5683 41 . . . cord-023095-4dannjjm 5684 1 Each each DT cord-023095-4dannjjm 5684 2 dog dog NN cord-023095-4dannjjm 5684 3 was be VBD cord-023095-4dannjjm 5684 4 treated treat VBN cord-023095-4dannjjm 5684 5 orally orally RB cord-023095-4dannjjm 5684 6 daily daily RB cord-023095-4dannjjm 5684 7 for for IN cord-023095-4dannjjm 5684 8 six six CD cord-023095-4dannjjm 5684 9 weeks week NNS cord-023095-4dannjjm 5684 10 along along IN cord-023095-4dannjjm 5684 11 with with IN cord-023095-4dannjjm 5684 12 550 550 CD cord-023095-4dannjjm 5684 13 mg mg NN cord-023095-4dannjjm 5684 14 betaine betaine NN cord-023095-4dannjjm 5684 15 HCl HCl NNP cord-023095-4dannjjm 5684 16 , , , cord-023095-4dannjjm 5684 17 that that IN cord-023095-4dannjjm 5684 18 aids aids NNP cord-023095-4dannjjm 5684 19 in in IN cord-023095-4dannjjm 5684 20 peptide peptide JJ cord-023095-4dannjjm 5684 21 absorption absorption NN cord-023095-4dannjjm 5684 22 . . . cord-023095-4dannjjm 5685 1 All all DT cord-023095-4dannjjm 5685 2 patients patient NNS cord-023095-4dannjjm 5685 3 were be VBD cord-023095-4dannjjm 5685 4 evaluated evaluate VBN cord-023095-4dannjjm 5685 5 for for IN cord-023095-4dannjjm 5685 6 toxicity toxicity NN cord-023095-4dannjjm 5685 7 using use VBG cord-023095-4dannjjm 5685 8 the the DT cord-023095-4dannjjm 5685 9 VCOG VCOG NNP cord-023095-4dannjjm 5685 10 - - HYPH cord-023095-4dannjjm 5685 11 CTCAE CTCAE NNP cord-023095-4dannjjm 5685 12 and and CC cord-023095-4dannjjm 5685 13 efficacy efficacy NN cord-023095-4dannjjm 5685 14 using use VBG cord-023095-4dannjjm 5685 15 the the DT cord-023095-4dannjjm 5685 16 RECIST RECIST NNP cord-023095-4dannjjm 5685 17 criteria criterion NNS cord-023095-4dannjjm 5685 18 via via IN cord-023095-4dannjjm 5685 19 assessment assessment NN cord-023095-4dannjjm 5685 20 of of IN cord-023095-4dannjjm 5685 21 clinical clinical JJ cord-023095-4dannjjm 5685 22 parameters parameter NNS cord-023095-4dannjjm 5685 23 , , , cord-023095-4dannjjm 5685 24 blood blood NN cord-023095-4dannjjm 5685 25 work work NN cord-023095-4dannjjm 5685 26 and and CC cord-023095-4dannjjm 5685 27 client client NN cord-023095-4dannjjm 5685 28 questionnaires questionnaire NNS cord-023095-4dannjjm 5685 29 . . . cord-023095-4dannjjm 5686 1 No no DT cord-023095-4dannjjm 5686 2 toxicity toxicity NN cord-023095-4dannjjm 5686 3 other other JJ cord-023095-4dannjjm 5686 4 than than IN cord-023095-4dannjjm 5686 5 mild mild JJ cord-023095-4dannjjm 5686 6 , , , cord-023095-4dannjjm 5686 7 transient transient JJ cord-023095-4dannjjm 5686 8 ( ( -LRB- cord-023095-4dannjjm 5686 9 grade grade NN cord-023095-4dannjjm 5686 10 I i NN cord-023095-4dannjjm 5686 11 ) ) -RRB- cord-023095-4dannjjm 5686 12 nausea nausea NN cord-023095-4dannjjm 5686 13 was be VBD cord-023095-4dannjjm 5686 14 noted note VBN cord-023095-4dannjjm 5686 15 , , , cord-023095-4dannjjm 5686 16 nor nor CC cord-023095-4dannjjm 5686 17 were be VBD cord-023095-4dannjjm 5686 18 there there EX cord-023095-4dannjjm 5686 19 any any DT cord-023095-4dannjjm 5686 20 changes change NNS cord-023095-4dannjjm 5686 21 in in IN cord-023095-4dannjjm 5686 22 hemograms hemogram NNS cord-023095-4dannjjm 5686 23 or or CC cord-023095-4dannjjm 5686 24 biochemical biochemical JJ cord-023095-4dannjjm 5686 25 profiles profile NNS cord-023095-4dannjjm 5686 26 in in IN cord-023095-4dannjjm 5686 27 any any DT cord-023095-4dannjjm 5686 28 patient patient NN cord-023095-4dannjjm 5686 29 . . . cord-023095-4dannjjm 5687 1 Dogs dog NNS cord-023095-4dannjjm 5687 2 with with IN cord-023095-4dannjjm 5687 3 tumors tumor NNS cord-023095-4dannjjm 5687 4 that that WDT cord-023095-4dannjjm 5687 5 were be VBD cord-023095-4dannjjm 5687 6 confirmed confirm VBN cord-023095-4dannjjm 5687 7 as as IN cord-023095-4dannjjm 5687 8 responders responder NNS cord-023095-4dannjjm 5687 9 ( ( -LRB- cord-023095-4dannjjm 5687 10 4 4 CD cord-023095-4dannjjm 5687 11 50 50 CD cord-023095-4dannjjm 5687 12 % % NN cord-023095-4dannjjm 5687 13 reduction reduction NN cord-023095-4dannjjm 5687 14 in in IN cord-023095-4dannjjm 5687 15 size size NN cord-023095-4dannjjm 5687 16 ) ) -RRB- cord-023095-4dannjjm 5687 17 include include VBP cord-023095-4dannjjm 5687 18 pulmonary pulmonary JJ cord-023095-4dannjjm 5687 19 adenocarcinoma adenocarcinoma NN cord-023095-4dannjjm 5687 20 , , , cord-023095-4dannjjm 5687 21 mast mast NN cord-023095-4dannjjm 5687 22 cell cell NN cord-023095-4dannjjm 5687 23 tumor tumor NN cord-023095-4dannjjm 5687 24 , , , cord-023095-4dannjjm 5687 25 trichoepithelioma trichoepithelioma NNP cord-023095-4dannjjm 5687 26 and and CC cord-023095-4dannjjm 5687 27 soft soft JJ cord-023095-4dannjjm 5687 28 tissue tissue NN cord-023095-4dannjjm 5687 29 sarcoma sarcoma NN cord-023095-4dannjjm 5687 30 . . . cord-023095-4dannjjm 5688 1 It -PRON- PRP cord-023095-4dannjjm 5688 2 appears appear VBZ cord-023095-4dannjjm 5688 3 in in IN cord-023095-4dannjjm 5688 4 limited limited JJ cord-023095-4dannjjm 5688 5 studies study NNS cord-023095-4dannjjm 5688 6 that that WDT cord-023095-4dannjjm 5688 7 the the DT cord-023095-4dannjjm 5688 8 response response NN cord-023095-4dannjjm 5688 9 rate rate NN cord-023095-4dannjjm 5688 10 may may MD cord-023095-4dannjjm 5688 11 be be VB cord-023095-4dannjjm 5688 12 more more RBR cord-023095-4dannjjm 5688 13 durable durable JJ cord-023095-4dannjjm 5688 14 at at IN cord-023095-4dannjjm 5688 15 higher high JJR cord-023095-4dannjjm 5688 16 dosages dosage NNS cord-023095-4dannjjm 5688 17 . . . cord-023095-4dannjjm 5689 1 The the DT cord-023095-4dannjjm 5689 2 response response NN cord-023095-4dannjjm 5689 3 to to IN cord-023095-4dannjjm 5689 4 Aminoact Aminoact NNP cord-023095-4dannjjm 5689 5 is be VBZ cord-023095-4dannjjm 5689 6 dose dose NN cord-023095-4dannjjm 5689 7 dependent dependent JJ cord-023095-4dannjjm 5689 8 and and CC cord-023095-4dannjjm 5689 9 only only JJ cord-023095-4dannjjm 5689 10 transient transient JJ cord-023095-4dannjjm 5689 11 mild mild JJ cord-023095-4dannjjm 5689 12 toxicity toxicity NN cord-023095-4dannjjm 5689 13 was be VBD cord-023095-4dannjjm 5689 14 observed observe VBN cord-023095-4dannjjm 5689 15 , , , cord-023095-4dannjjm 5689 16 which which WDT cord-023095-4dannjjm 5689 17 suggest suggest VBP cord-023095-4dannjjm 5689 18 the the DT cord-023095-4dannjjm 5689 19 maximum maximum JJ cord-023095-4dannjjm 5689 20 effective effective JJ cord-023095-4dannjjm 5689 21 dosage dosage NN cord-023095-4dannjjm 5689 22 has have VBZ cord-023095-4dannjjm 5689 23 not not RB cord-023095-4dannjjm 5689 24 been be VBN cord-023095-4dannjjm 5689 25 reached reach VBN cord-023095-4dannjjm 5689 26 . . . cord-023095-4dannjjm 5690 1 Further further JJ cord-023095-4dannjjm 5690 2 clinical clinical JJ cord-023095-4dannjjm 5690 3 studies study NNS cord-023095-4dannjjm 5690 4 will will MD cord-023095-4dannjjm 5690 5 be be VB cord-023095-4dannjjm 5690 6 valuable valuable JJ cord-023095-4dannjjm 5690 7 in in IN cord-023095-4dannjjm 5690 8 determining determine VBG cord-023095-4dannjjm 5690 9 the the DT cord-023095-4dannjjm 5690 10 effective effective JJ cord-023095-4dannjjm 5690 11 dosage dosage NN cord-023095-4dannjjm 5690 12 and and CC cord-023095-4dannjjm 5690 13 response response NN cord-023095-4dannjjm 5690 14 duration duration NN cord-023095-4dannjjm 5690 15 . . . cord-023095-4dannjjm 5691 1 Treating treat VBG cord-023095-4dannjjm 5691 2 cancer cancer NN cord-023095-4dannjjm 5691 3 in in IN cord-023095-4dannjjm 5691 4 dogs dog NNS cord-023095-4dannjjm 5691 5 with with IN cord-023095-4dannjjm 5691 6 Aminoact Aminoact NNP cord-023095-4dannjjm 5691 7 offers offer VBZ cord-023095-4dannjjm 5691 8 a a DT cord-023095-4dannjjm 5691 9 unique unique JJ cord-023095-4dannjjm 5691 10 opportunity opportunity NN cord-023095-4dannjjm 5691 11 as as IN cord-023095-4dannjjm 5691 12 a a DT cord-023095-4dannjjm 5691 13 model model NN cord-023095-4dannjjm 5691 14 for for IN cord-023095-4dannjjm 5691 15 human human JJ cord-023095-4dannjjm 5691 16 cancer cancer NN cord-023095-4dannjjm 5691 17 biology biology NN cord-023095-4dannjjm 5691 18 and and CC cord-023095-4dannjjm 5691 19 translational translational JJ cord-023095-4dannjjm 5691 20 cancer cancer NN cord-023095-4dannjjm 5691 21 therapeutics therapeutic NNS cord-023095-4dannjjm 5691 22 . . . cord-023095-4dannjjm 5692 1 Stereotactic stereotactic JJ cord-023095-4dannjjm 5692 2 radiation radiation NN cord-023095-4dannjjm 5692 3 therapy therapy NN cord-023095-4dannjjm 5692 4 ( ( -LRB- cord-023095-4dannjjm 5692 5 SRT SRT NNP cord-023095-4dannjjm 5692 6 ) ) -RRB- cord-023095-4dannjjm 5692 7 combines combine VBZ cord-023095-4dannjjm 5692 8 patient patient JJ cord-023095-4dannjjm 5692 9 immobilization immobilization NN cord-023095-4dannjjm 5692 10 , , , cord-023095-4dannjjm 5692 11 image image NN cord-023095-4dannjjm 5692 12 guidance guidance NN cord-023095-4dannjjm 5692 13 , , , cord-023095-4dannjjm 5692 14 and and CC cord-023095-4dannjjm 5692 15 intensity intensity NN cord-023095-4dannjjm 5692 16 modulated modulate VBN cord-023095-4dannjjm 5692 17 delivery delivery NN cord-023095-4dannjjm 5692 18 to to TO cord-023095-4dannjjm 5692 19 achieve achieve VB cord-023095-4dannjjm 5692 20 ablative ablative JJ cord-023095-4dannjjm 5692 21 radiation radiation NN cord-023095-4dannjjm 5692 22 doses dose NNS cord-023095-4dannjjm 5692 23 within within IN cord-023095-4dannjjm 5692 24 the the DT cord-023095-4dannjjm 5692 25 tumor tumor NN cord-023095-4dannjjm 5692 26 , , , cord-023095-4dannjjm 5692 27 while while IN cord-023095-4dannjjm 5692 28 preferentially preferentially RB cord-023095-4dannjjm 5692 29 sparing spare VBG cord-023095-4dannjjm 5692 30 surrounding surround VBG cord-023095-4dannjjm 5692 31 normal normal JJ cord-023095-4dannjjm 5692 32 tissues tissue NNS cord-023095-4dannjjm 5692 33 . . . cord-023095-4dannjjm 5693 1 The the DT cord-023095-4dannjjm 5693 2 purpose purpose NN cord-023095-4dannjjm 5693 3 of of IN cord-023095-4dannjjm 5693 4 this this DT cord-023095-4dannjjm 5693 5 study study NN cord-023095-4dannjjm 5693 6 was be VBD cord-023095-4dannjjm 5693 7 to to TO cord-023095-4dannjjm 5693 8 evaluate evaluate VB cord-023095-4dannjjm 5693 9 the the DT cord-023095-4dannjjm 5693 10 efficacy efficacy NN cord-023095-4dannjjm 5693 11 of of IN cord-023095-4dannjjm 5693 12 SRT SRT NNP cord-023095-4dannjjm 5693 13 as as IN cord-023095-4dannjjm 5693 14 a a DT cord-023095-4dannjjm 5693 15 means means NN cord-023095-4dannjjm 5693 16 of of IN cord-023095-4dannjjm 5693 17 achieving achieve VBG cord-023095-4dannjjm 5693 18 local local JJ cord-023095-4dannjjm 5693 19 tumor tumor NN cord-023095-4dannjjm 5693 20 control control NN cord-023095-4dannjjm 5693 21 for for IN cord-023095-4dannjjm 5693 22 canine canine JJ cord-023095-4dannjjm 5693 23 nasal nasal NN cord-023095-4dannjjm 5693 24 tumors tumor NNS cord-023095-4dannjjm 5693 25 . . . cord-023095-4dannjjm 5694 1 Retrospective retrospective JJ cord-023095-4dannjjm 5694 2 analysis analysis NN cord-023095-4dannjjm 5694 3 was be VBD cord-023095-4dannjjm 5694 4 performed perform VBN cord-023095-4dannjjm 5694 5 on on IN cord-023095-4dannjjm 5694 6 dogs dog NNS cord-023095-4dannjjm 5694 7 with with IN cord-023095-4dannjjm 5694 8 a a DT cord-023095-4dannjjm 5694 9 nasal nasal NN cord-023095-4dannjjm 5694 10 tumor tumor NN cord-023095-4dannjjm 5694 11 confirmed confirm VBN cord-023095-4dannjjm 5694 12 by by IN cord-023095-4dannjjm 5694 13 histopathology histopathology NN cord-023095-4dannjjm 5694 14 and and CC cord-023095-4dannjjm 5694 15 computed compute VBN cord-023095-4dannjjm 5694 16 tomography tomography NN cord-023095-4dannjjm 5694 17 , , , cord-023095-4dannjjm 5694 18 no no DT cord-023095-4dannjjm 5694 19 previous previous JJ cord-023095-4dannjjm 5694 20 surgical surgical NN cord-023095-4dannjjm 5694 21 or or CC cord-023095-4dannjjm 5694 22 radiation radiation NN cord-023095-4dannjjm 5694 23 therapy therapy NN cord-023095-4dannjjm 5694 24 , , , cord-023095-4dannjjm 5694 25 at at IN cord-023095-4dannjjm 5694 26 least least JJS cord-023095-4dannjjm 5694 27 six six CD cord-023095-4dannjjm 5694 28 months month NNS cord-023095-4dannjjm 5694 29 of of IN cord-023095-4dannjjm 5694 30 follow follow NN cord-023095-4dannjjm 5694 31 - - HYPH cord-023095-4dannjjm 5694 32 up up NN cord-023095-4dannjjm 5694 33 , , , cord-023095-4dannjjm 5694 34 and and CC cord-023095-4dannjjm 5694 35 completion completion NN cord-023095-4dannjjm 5694 36 of of IN cord-023095-4dannjjm 5694 37 three three CD cord-023095-4dannjjm 5694 38 fractions fraction NNS cord-023095-4dannjjm 5694 39 of of IN cord-023095-4dannjjm 5694 40 SRT SRT NNP cord-023095-4dannjjm 5694 41 at at IN cord-023095-4dannjjm 5694 42 CSU.SRT CSU.SRT NNP cord-023095-4dannjjm 5694 43 was be VBD cord-023095-4dannjjm 5694 44 administered administer VBN cord-023095-4dannjjm 5694 45 via via IN cord-023095-4dannjjm 5694 46 the the DT cord-023095-4dannjjm 5694 47 Varian Varian NNP cord-023095-4dannjjm 5694 48 Trilogy Trilogy NNP cord-023095-4dannjjm 5694 49 linear linear JJ cord-023095-4dannjjm 5694 50 accelerator accelerator NN cord-023095-4dannjjm 5694 51 once once RB cord-023095-4dannjjm 5694 52 daily daily RB cord-023095-4dannjjm 5694 53 for for IN cord-023095-4dannjjm 5694 54 three three CD cord-023095-4dannjjm 5694 55 consecutive consecutive JJ cord-023095-4dannjjm 5694 56 days day NNS cord-023095-4dannjjm 5694 57 . . . cord-023095-4dannjjm 5695 1 The the DT cord-023095-4dannjjm 5695 2 Varian Varian NNP cord-023095-4dannjjm 5695 3 Eclipse Eclipse NNP cord-023095-4dannjjm 5695 4 treatment treatment NN cord-023095-4dannjjm 5695 5 planwas planwas NN cord-023095-4dannjjm 5695 6 reviewed review VBN cord-023095-4dannjjm 5695 7 to to TO cord-023095-4dannjjm 5695 8 determine determine VB cord-023095-4dannjjm 5695 9 the the DT cord-023095-4dannjjm 5695 10 planned plan VBN cord-023095-4dannjjm 5695 11 target target NN cord-023095-4dannjjm 5695 12 volume volume NN cord-023095-4dannjjm 5695 13 ( ( -LRB- cord-023095-4dannjjm 5695 14 PTV PTV NNP cord-023095-4dannjjm 5695 15 ) ) -RRB- cord-023095-4dannjjm 5695 16 and and CC cord-023095-4dannjjm 5695 17 dose dose VBD cord-023095-4dannjjm 5695 18 to to IN cord-023095-4dannjjm 5695 19 95 95 CD cord-023095-4dannjjm 5695 20 % % NN cord-023095-4dannjjm 5695 21 of of IN cord-023095-4dannjjm 5695 22 the the DT cord-023095-4dannjjm 5695 23 PTV PTV NNP cord-023095-4dannjjm 5695 24 . . . cord-023095-4dannjjm 5696 1 Kaplan Kaplan NNP cord-023095-4dannjjm 5696 2 - - HYPH cord-023095-4dannjjm 5696 3 Meir Meir NNP cord-023095-4dannjjm 5696 4 survival survival NN cord-023095-4dannjjm 5696 5 analysis analysis NN cord-023095-4dannjjm 5696 6 was be VBD cord-023095-4dannjjm 5696 7 performed perform VBN cord-023095-4dannjjm 5696 8 for for IN cord-023095-4dannjjm 5696 9 disease disease NN cord-023095-4dannjjm 5696 10 free free JJ cord-023095-4dannjjm 5696 11 interval interval NN cord-023095-4dannjjm 5696 12 ( ( -LRB- cord-023095-4dannjjm 5696 13 DFI DFI NNP cord-023095-4dannjjm 5696 14 ) ) -RRB- cord-023095-4dannjjm 5696 15 and and CC cord-023095-4dannjjm 5696 16 overall overall JJ cord-023095-4dannjjm 5696 17 survival survival NN cord-023095-4dannjjm 5696 18 ( ( -LRB- cord-023095-4dannjjm 5696 19 OS OS NNP cord-023095-4dannjjm 5696 20 ) ) -RRB- cord-023095-4dannjjm 5696 21 . . . cord-023095-4dannjjm 5697 1 Sixteen sixteen CD cord-023095-4dannjjm 5697 2 patients patient NNS cord-023095-4dannjjm 5697 3 with with IN cord-023095-4dannjjm 5697 4 nasal nasal NN cord-023095-4dannjjm 5697 5 tumors tumor NNS cord-023095-4dannjjm 5697 6 ( ( -LRB- cord-023095-4dannjjm 5697 7 8 8 CD cord-023095-4dannjjm 5697 8 adenocarcinoma adenocarcinoma NN cord-023095-4dannjjm 5697 9 / / SYM cord-023095-4dannjjm 5697 10 carcinomas carcinoma NNS cord-023095-4dannjjm 5697 11 , , , cord-023095-4dannjjm 5697 12 2 2 CD cord-023095-4dannjjm 5697 13 squamous squamous JJ cord-023095-4dannjjm 5697 14 cell cell NN cord-023095-4dannjjm 5697 15 carcinomas carcinoma NNS cord-023095-4dannjjm 5697 16 , , , cord-023095-4dannjjm 5697 17 3 3 CD cord-023095-4dannjjm 5697 18 chondrosarcomas chondrosarcoma NNS cord-023095-4dannjjm 5697 19 , , , cord-023095-4dannjjm 5697 20 2 2 CD cord-023095-4dannjjm 5697 21 osteosarcomas osteosarcoma NNS cord-023095-4dannjjm 5697 22 , , , cord-023095-4dannjjm 5697 23 and and CC cord-023095-4dannjjm 5697 24 1 1 CD cord-023095-4dannjjm 5697 25 undifferentiated undifferentiated JJ cord-023095-4dannjjm 5697 26 sarcoma sarcoma NN cord-023095-4dannjjm 5697 27 ) ) -RRB- cord-023095-4dannjjm 5697 28 were be VBD cord-023095-4dannjjm 5697 29 treated treat VBN cord-023095-4dannjjm 5697 30 with with IN cord-023095-4dannjjm 5697 31 SRT SRT NNP cord-023095-4dannjjm 5697 32 . . . cord-023095-4dannjjm 5698 1 A a DT cord-023095-4dannjjm 5698 2 median median JJ cord-023095-4dannjjm 5698 3 dose dose NN cord-023095-4dannjjm 5698 4 of of IN cord-023095-4dannjjm 5698 5 29.1Gy 29.1gy CD cord-023095-4dannjjm 5698 6 was be VBD cord-023095-4dannjjm 5698 7 administered administer VBN cord-023095-4dannjjm 5698 8 to to IN cord-023095-4dannjjm 5698 9 95 95 CD cord-023095-4dannjjm 5698 10 % % NN cord-023095-4dannjjm 5698 11 PTV PTV NNP cord-023095-4dannjjm 5698 12 with with IN cord-023095-4dannjjm 5698 13 a a DT cord-023095-4dannjjm 5698 14 median median JJ cord-023095-4dannjjm 5698 15 PTV PTV NNP cord-023095-4dannjjm 5698 16 of of IN cord-023095-4dannjjm 5698 17 75.3cc 75.3cc NN cord-023095-4dannjjm 5698 18 . . . cord-023095-4dannjjm 5699 1 SRT SRT NNP cord-023095-4dannjjm 5699 2 was be VBD cord-023095-4dannjjm 5699 3 well well RB cord-023095-4dannjjm 5699 4 tolerated tolerate VBN cord-023095-4dannjjm 5699 5 by by IN cord-023095-4dannjjm 5699 6 the the DT cord-023095-4dannjjm 5699 7 normal normal JJ cord-023095-4dannjjm 5699 8 tissues tissue NNS cord-023095-4dannjjm 5699 9 with with IN cord-023095-4dannjjm 5699 10 minimal minimal JJ cord-023095-4dannjjm 5699 11 , , , cord-023095-4dannjjm 5699 12 manageable manageable JJ cord-023095-4dannjjm 5699 13 side side NN cord-023095-4dannjjm 5699 14 effects effect NNS cord-023095-4dannjjm 5699 15 . . . cord-023095-4dannjjm 5700 1 To to IN cord-023095-4dannjjm 5700 2 date date NN cord-023095-4dannjjm 5700 3 , , , cord-023095-4dannjjm 5700 4 the the DT cord-023095-4dannjjm 5700 5 median median JJ cord-023095-4dannjjm 5700 6 DFI DFI NNP cord-023095-4dannjjm 5700 7 is be VBZ cord-023095-4dannjjm 5700 8 270 270 CD cord-023095-4dannjjm 5700 9 days day NNS cord-023095-4dannjjm 5700 10 , , , cord-023095-4dannjjm 5700 11 while while IN cord-023095-4dannjjm 5700 12 the the DT cord-023095-4dannjjm 5700 13 median median JJ cord-023095-4dannjjm 5700 14 OS OS NNP cord-023095-4dannjjm 5700 15 is be VBZ cord-023095-4dannjjm 5700 16 367 367 CD cord-023095-4dannjjm 5700 17 days day NNS cord-023095-4dannjjm 5700 18 . . . cord-023095-4dannjjm 5701 1 Based base VBN cord-023095-4dannjjm 5701 2 upon upon IN cord-023095-4dannjjm 5701 3 the the DT cord-023095-4dannjjm 5701 4 initial initial JJ cord-023095-4dannjjm 5701 5 clinical clinical JJ cord-023095-4dannjjm 5701 6 experience experience NN cord-023095-4dannjjm 5701 7 , , , cord-023095-4dannjjm 5701 8 stereotactic stereotactic JJ cord-023095-4dannjjm 5701 9 radiation radiation NN cord-023095-4dannjjm 5701 10 therapy therapy NN cord-023095-4dannjjm 5701 11 is be VBZ cord-023095-4dannjjm 5701 12 an an DT cord-023095-4dannjjm 5701 13 emerging emerge VBG cord-023095-4dannjjm 5701 14 modality modality NN cord-023095-4dannjjm 5701 15 in in IN cord-023095-4dannjjm 5701 16 the the DT cord-023095-4dannjjm 5701 17 management management NN cord-023095-4dannjjm 5701 18 of of IN cord-023095-4dannjjm 5701 19 canine canine JJ cord-023095-4dannjjm 5701 20 nasal nasal NN cord-023095-4dannjjm 5701 21 tumors tumor NNS cord-023095-4dannjjm 5701 22 . . . cord-023095-4dannjjm 5702 1 Canine canine JJ cord-023095-4dannjjm 5702 2 Leptospirosis leptospirosis NN cord-023095-4dannjjm 5702 3 can can MD cord-023095-4dannjjm 5702 4 vary vary VB cord-023095-4dannjjm 5702 5 from from IN cord-023095-4dannjjm 5702 6 subclinical subclinical JJ cord-023095-4dannjjm 5702 7 infection infection NN cord-023095-4dannjjm 5702 8 to to IN cord-023095-4dannjjm 5702 9 illness illness NN cord-023095-4dannjjm 5702 10 that that WDT cord-023095-4dannjjm 5702 11 ranges range VBZ cord-023095-4dannjjm 5702 12 from from IN cord-023095-4dannjjm 5702 13 mild mild JJ cord-023095-4dannjjm 5702 14 to to IN cord-023095-4dannjjm 5702 15 severe severe JJ cord-023095-4dannjjm 5702 16 , , , cord-023095-4dannjjm 5702 17 including include VBG cord-023095-4dannjjm 5702 18 death death NN cord-023095-4dannjjm 5702 19 , , , cord-023095-4dannjjm 5702 20 depending depend VBG cord-023095-4dannjjm 5702 21 on on IN cord-023095-4dannjjm 5702 22 the the DT cord-023095-4dannjjm 5702 23 susceptibility susceptibility NN cord-023095-4dannjjm 5702 24 of of IN cord-023095-4dannjjm 5702 25 the the DT cord-023095-4dannjjm 5702 26 dog dog NN cord-023095-4dannjjm 5702 27 , , , cord-023095-4dannjjm 5702 28 virulence virulence NN cord-023095-4dannjjm 5702 29 of of IN cord-023095-4dannjjm 5702 30 the the DT cord-023095-4dannjjm 5702 31 organism organism NN cord-023095-4dannjjm 5702 32 , , , cord-023095-4dannjjm 5702 33 and and CC cord-023095-4dannjjm 5702 34 route route NN cord-023095-4dannjjm 5702 35 and and CC cord-023095-4dannjjm 5702 36 degree degree NN cord-023095-4dannjjm 5702 37 of of IN cord-023095-4dannjjm 5702 38 infection infection NN cord-023095-4dannjjm 5702 39 . . . cord-023095-4dannjjm 5703 1 The the DT cord-023095-4dannjjm 5703 2 objective objective NN cord-023095-4dannjjm 5703 3 of of IN cord-023095-4dannjjm 5703 4 this this DT cord-023095-4dannjjm 5703 5 study study NN cord-023095-4dannjjm 5703 6 was be VBD cord-023095-4dannjjm 5703 7 to to TO cord-023095-4dannjjm 5703 8 evaluate evaluate VB cord-023095-4dannjjm 5703 9 the the DT cord-023095-4dannjjm 5703 10 ability ability NN cord-023095-4dannjjm 5703 11 of of IN cord-023095-4dannjjm 5703 12 a a DT cord-023095-4dannjjm 5703 13 canine canine JJ cord-023095-4dannjjm 5703 14 Leptospira Leptospira NNP cord-023095-4dannjjm 5703 15 bacterin bacterin NN cord-023095-4dannjjm 5703 16 to to TO cord-023095-4dannjjm 5703 17 prevent prevent VB cord-023095-4dannjjm 5703 18 infection infection NN cord-023095-4dannjjm 5703 19 and and CC cord-023095-4dannjjm 5703 20 disease disease NN cord-023095-4dannjjm 5703 21 following follow VBG cord-023095-4dannjjm 5703 22 challenge challenge NN cord-023095-4dannjjm 5703 23 with with IN cord-023095-4dannjjm 5703 24 virulent virulent JJ cord-023095-4dannjjm 5703 25 Leptospira Leptospira NNP cord-023095-4dannjjm 5703 26 canicola canicola NN cord-023095-4dannjjm 5703 27 , , , cord-023095-4dannjjm 5703 28 L. L. NNP cord-023095-4dannjjm 5703 29 pomona pomona NNP cord-023095-4dannjjm 5703 30 , , , cord-023095-4dannjjm 5703 31 L. L. NNP cord-023095-4dannjjm 5703 32 grippotyphosa grippotyphosa NNP cord-023095-4dannjjm 5703 33 , , , cord-023095-4dannjjm 5703 34 or or CC cord-023095-4dannjjm 5703 35 L. L. NNP cord-023095-4dannjjm 5703 36 icterohaemorrhagiae icterohaemorrhagiae NN cord-023095-4dannjjm 5703 37 . . . cord-023095-4dannjjm 5704 1 Groups group NNS cord-023095-4dannjjm 5704 2 of of IN cord-023095-4dannjjm 5704 3 8week 8week CD cord-023095-4dannjjm 5704 4 - - HYPH cord-023095-4dannjjm 5704 5 old old JJ cord-023095-4dannjjm 5704 6 beagles beagle NNS cord-023095-4dannjjm 5704 7 were be VBD cord-023095-4dannjjm 5704 8 vaccinated vaccinate VBN cord-023095-4dannjjm 5704 9 ( ( -LRB- cord-023095-4dannjjm 5704 10 day day NN cord-023095-4dannjjm 5704 11 0 0 CD cord-023095-4dannjjm 5704 12 ) ) -RRB- cord-023095-4dannjjm 5704 13 and and CC cord-023095-4dannjjm 5704 14 boosted boost VBN cord-023095-4dannjjm 5704 15 ( ( -LRB- cord-023095-4dannjjm 5704 16 day day NN cord-023095-4dannjjm 5704 17 21 21 CD cord-023095-4dannjjm 5704 18 ) ) -RRB- cord-023095-4dannjjm 5704 19 with with IN cord-023095-4dannjjm 5704 20 placebo placebo NN cord-023095-4dannjjm 5704 21 ( ( -LRB- cord-023095-4dannjjm 5704 22 n n NN cord-023095-4dannjjm 5704 23 5 5 CD cord-023095-4dannjjm 5704 24 10 10 CD cord-023095-4dannjjm 5704 25 ) ) -RRB- cord-023095-4dannjjm 5704 26 or or CC cord-023095-4dannjjm 5704 27 the the DT cord-023095-4dannjjm 5704 28 4-way 4-way JJ cord-023095-4dannjjm 5704 29 bacterin bacterin NNP cord-023095-4dannjjm 5704 30 ( ( -LRB- cord-023095-4dannjjm 5704 31 n n NN cord-023095-4dannjjm 5704 32 ! ! NNP cord-023095-4dannjjm 5704 33 20 20 CD cord-023095-4dannjjm 5704 34 ) ) -RRB- cord-023095-4dannjjm 5704 35 and and CC cord-023095-4dannjjm 5704 36 subsequently subsequently RB cord-023095-4dannjjm 5704 37 challenged challenge VBD cord-023095-4dannjjm 5704 38 with with IN cord-023095-4dannjjm 5704 39 each each DT cord-023095-4dannjjm 5704 40 serovar serovar NNP cord-023095-4dannjjm 5704 41 . . . cord-023095-4dannjjm 5705 1 The the DT cord-023095-4dannjjm 5705 2 results result NNS cord-023095-4dannjjm 5705 3 demonstrated demonstrate VBD cord-023095-4dannjjm 5705 4 that that IN cord-023095-4dannjjm 5705 5 blood blood NN cord-023095-4dannjjm 5705 6 and and CC cord-023095-4dannjjm 5705 7 various various JJ cord-023095-4dannjjm 5705 8 tissue tissue NN cord-023095-4dannjjm 5705 9 samples sample NNS cord-023095-4dannjjm 5705 10 from from IN cord-023095-4dannjjm 5705 11 placebo placebo NN cord-023095-4dannjjm 5705 12 - - HYPH cord-023095-4dannjjm 5705 13 recipients recipient NNS cord-023095-4dannjjm 5705 14 became become VBD cord-023095-4dannjjm 5705 15 reliably reliably RB cord-023095-4dannjjm 5705 16 infected infect VBN cord-023095-4dannjjm 5705 17 , , , cord-023095-4dannjjm 5705 18 and and CC cord-023095-4dannjjm 5705 19 the the DT cord-023095-4dannjjm 5705 20 dogs dog NNS cord-023095-4dannjjm 5705 21 developed develop VBD cord-023095-4dannjjm 5705 22 typical typical JJ cord-023095-4dannjjm 5705 23 clinical clinical JJ cord-023095-4dannjjm 5705 24 signs sign NNS cord-023095-4dannjjm 5705 25 of of IN cord-023095-4dannjjm 5705 26 Leptospirosis leptospirosis NN cord-023095-4dannjjm 5705 27 including include VBG cord-023095-4dannjjm 5705 28 loss loss NN cord-023095-4dannjjm 5705 29 of of IN cord-023095-4dannjjm 5705 30 appetite appetite NN cord-023095-4dannjjm 5705 31 , , , cord-023095-4dannjjm 5705 32 ocular ocular JJ cord-023095-4dannjjm 5705 33 congestion congestion NN cord-023095-4dannjjm 5705 34 , , , cord-023095-4dannjjm 5705 35 depression depression NN cord-023095-4dannjjm 5705 36 , , , cord-023095-4dannjjm 5705 37 dehydration dehydration NN cord-023095-4dannjjm 5705 38 , , , cord-023095-4dannjjm 5705 39 jaundice jaundice NN cord-023095-4dannjjm 5705 40 , , , cord-023095-4dannjjm 5705 41 hematuria hematuria NN cord-023095-4dannjjm 5705 42 , , , cord-023095-4dannjjm 5705 43 melena melena NN cord-023095-4dannjjm 5705 44 , , , cord-023095-4dannjjm 5705 45 vomiting vomiting NN cord-023095-4dannjjm 5705 46 , , , cord-023095-4dannjjm 5705 47 petechiae petechia NNS cord-023095-4dannjjm 5705 48 , , , cord-023095-4dannjjm 5705 49 and and CC cord-023095-4dannjjm 5705 50 death death NN cord-023095-4dannjjm 5705 51 . . . cord-023095-4dannjjm 5706 1 In in IN cord-023095-4dannjjm 5706 2 addition addition NN cord-023095-4dannjjm 5706 3 , , , cord-023095-4dannjjm 5706 4 placebo placebo NN cord-023095-4dannjjm 5706 5 - - HYPH cord-023095-4dannjjm 5706 6 recipients recipient NNS cord-023095-4dannjjm 5706 7 developed develop VBD cord-023095-4dannjjm 5706 8 kidney kidney NN cord-023095-4dannjjm 5706 9 and and CC cord-023095-4dannjjm 5706 10 liver liver NN cord-023095-4dannjjm 5706 11 dysfunction dysfunction NN cord-023095-4dannjjm 5706 12 . . . cord-023095-4dannjjm 5707 1 In in IN cord-023095-4dannjjm 5707 2 contrast contrast NN cord-023095-4dannjjm 5707 3 , , , cord-023095-4dannjjm 5707 4 some some DT cord-023095-4dannjjm 5707 5 vaccine vaccine NN cord-023095-4dannjjm 5707 6 - - HYPH cord-023095-4dannjjm 5707 7 recipients recipient NNS cord-023095-4dannjjm 5707 8 became become VBD cord-023095-4dannjjm 5707 9 infected infected JJ cord-023095-4dannjjm 5707 10 , , , cord-023095-4dannjjm 5707 11 but but CC cord-023095-4dannjjm 5707 12 the the DT cord-023095-4dannjjm 5707 13 organisms organism NNS cord-023095-4dannjjm 5707 14 were be VBD cord-023095-4dannjjm 5707 15 cleared clear VBN cord-023095-4dannjjm 5707 16 quickly quickly RB cord-023095-4dannjjm 5707 17 from from IN cord-023095-4dannjjm 5707 18 the the DT cord-023095-4dannjjm 5707 19 blood blood NN cord-023095-4dannjjm 5707 20 . . . cord-023095-4dannjjm 5708 1 Vaccinated vaccinated JJ cord-023095-4dannjjm 5708 2 dogs dog NNS cord-023095-4dannjjm 5708 3 failed fail VBD cord-023095-4dannjjm 5708 4 to to TO cord-023095-4dannjjm 5708 5 develop develop VB cord-023095-4dannjjm 5708 6 severe severe JJ cord-023095-4dannjjm 5708 7 clinical clinical JJ cord-023095-4dannjjm 5708 8 disease disease NN cord-023095-4dannjjm 5708 9 requiring require VBG cord-023095-4dannjjm 5708 10 medical medical JJ cord-023095-4dannjjm 5708 11 intervention intervention NN cord-023095-4dannjjm 5708 12 , , , cord-023095-4dannjjm 5708 13 and and CC cord-023095-4dannjjm 5708 14 no no DT cord-023095-4dannjjm 5708 15 animals animal NNS cord-023095-4dannjjm 5708 16 died die VBD cord-023095-4dannjjm 5708 17 ( ( -LRB- cord-023095-4dannjjm 5708 18 p p NN cord-023095-4dannjjm 5708 19 ! ! . cord-023095-4dannjjm 5708 20 0.001 0.001 CD cord-023095-4dannjjm 5708 21 ) ) -RRB- cord-023095-4dannjjm 5708 22 . . . cord-023095-4dannjjm 5709 1 A a DT cord-023095-4dannjjm 5709 2 few few JJ cord-023095-4dannjjm 5709 3 of of IN cord-023095-4dannjjm 5709 4 the the DT cord-023095-4dannjjm 5709 5 vaccinated vaccinate VBN cord-023095-4dannjjm 5709 6 dogs dog NNS cord-023095-4dannjjm 5709 7 developed develop VBD cord-023095-4dannjjm 5709 8 clinical clinical JJ cord-023095-4dannjjm 5709 9 abnormalities abnormality NNS cord-023095-4dannjjm 5709 10 , , , cord-023095-4dannjjm 5709 11 but but CC cord-023095-4dannjjm 5709 12 the the DT cord-023095-4dannjjm 5709 13 clinical clinical JJ cord-023095-4dannjjm 5709 14 signs sign NNS cord-023095-4dannjjm 5709 15 remained remain VBD cord-023095-4dannjjm 5709 16 mild mild JJ cord-023095-4dannjjm 5709 17 and and CC cord-023095-4dannjjm 5709 18 were be VBD cord-023095-4dannjjm 5709 19 self self NN cord-023095-4dannjjm 5709 20 - - HYPH cord-023095-4dannjjm 5709 21 limiting limit VBG cord-023095-4dannjjm 5709 22 ( ( -LRB- cord-023095-4dannjjm 5709 23 p p NN cord-023095-4dannjjm 5709 24 o o NN cord-023095-4dannjjm 5709 25 0.0001 0.0001 CD cord-023095-4dannjjm 5709 26 for for IN cord-023095-4dannjjm 5709 27 each each DT cord-023095-4dannjjm 5709 28 serovar serovar NNP cord-023095-4dannjjm 5709 29 ) ) -RRB- cord-023095-4dannjjm 5709 30 . . . cord-023095-4dannjjm 5710 1 Administration administration NN cord-023095-4dannjjm 5710 2 of of IN cord-023095-4dannjjm 5710 3 the the DT cord-023095-4dannjjm 5710 4 bacterin bacterin NNP cord-023095-4dannjjm 5710 5 also also RB cord-023095-4dannjjm 5710 6 prevented prevent VBD cord-023095-4dannjjm 5710 7 thrombocytopenia thrombocytopenia NN cord-023095-4dannjjm 5711 1 ( ( -LRB- cord-023095-4dannjjm 5711 2 Ciprofloxacin Ciprofloxacin NNP cord-023095-4dannjjm 5711 3 , , , cord-023095-4dannjjm 5711 4 a a DT cord-023095-4dannjjm 5711 5 synthetic synthetic JJ cord-023095-4dannjjm 5711 6 fluoroquinolone fluoroquinolone NN cord-023095-4dannjjm 5711 7 antimicrobic antimicrobic NNP cord-023095-4dannjjm 5711 8 , , , cord-023095-4dannjjm 5711 9 is be VBZ cord-023095-4dannjjm 5711 10 not not RB cord-023095-4dannjjm 5711 11 FDA FDA NNP cord-023095-4dannjjm 5711 12 - - HYPH cord-023095-4dannjjm 5711 13 approved approve VBN cord-023095-4dannjjm 5711 14 for for IN cord-023095-4dannjjm 5711 15 veterinary veterinary JJ cord-023095-4dannjjm 5711 16 use use NN cord-023095-4dannjjm 5711 17 . . . cord-023095-4dannjjm 5712 1 However however RB cord-023095-4dannjjm 5712 2 , , , cord-023095-4dannjjm 5712 3 due due IN cord-023095-4dannjjm 5712 4 to to IN cord-023095-4dannjjm 5712 5 recent recent JJ cord-023095-4dannjjm 5712 6 availability availability NN cord-023095-4dannjjm 5712 7 of of IN cord-023095-4dannjjm 5712 8 less less RBR cord-023095-4dannjjm 5712 9 expensive expensive JJ cord-023095-4dannjjm 5712 10 generic generic JJ cord-023095-4dannjjm 5712 11 formulations formulation NNS cord-023095-4dannjjm 5712 12 , , , cord-023095-4dannjjm 5712 13 extra extra JJ cord-023095-4dannjjm 5712 14 - - JJ cord-023095-4dannjjm 5712 15 label label JJ cord-023095-4dannjjm 5712 16 use use NN cord-023095-4dannjjm 5712 17 of of IN cord-023095-4dannjjm 5712 18 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 5712 19 by by IN cord-023095-4dannjjm 5712 20 veterinarians veterinarian NNS cord-023095-4dannjjm 5712 21 appears appear VBZ cord-023095-4dannjjm 5712 22 more more RBR cord-023095-4dannjjm 5712 23 common common JJ cord-023095-4dannjjm 5712 24 . . . cord-023095-4dannjjm 5713 1 Although although IN cord-023095-4dannjjm 5713 2 ciprofloxacin ciprofloxacin NNP cord-023095-4dannjjm 5713 3 crystalluria crystalluria NNP cord-023095-4dannjjm 5713 4 and and CC cord-023095-4dannjjm 5713 5 uroliths uroliths NNP cord-023095-4dannjjm 5713 6 have have VBP cord-023095-4dannjjm 5713 7 been be VBN cord-023095-4dannjjm 5713 8 reported report VBN cord-023095-4dannjjm 5713 9 in in IN cord-023095-4dannjjm 5713 10 humans human NNS cord-023095-4dannjjm 5713 11 , , , cord-023095-4dannjjm 5713 12 we -PRON- PRP cord-023095-4dannjjm 5713 13 are be VBP cord-023095-4dannjjm 5713 14 unaware unaware JJ cord-023095-4dannjjm 5713 15 of of IN cord-023095-4dannjjm 5713 16 any any DT cord-023095-4dannjjm 5713 17 published publish VBN cord-023095-4dannjjm 5713 18 reports report NNS cord-023095-4dannjjm 5713 19 in in IN cord-023095-4dannjjm 5713 20 dogs dog NNS cord-023095-4dannjjm 5713 21 . . . cord-023095-4dannjjm 5714 1 This this DT cord-023095-4dannjjm 5714 2 is be VBZ cord-023095-4dannjjm 5714 3 surprising surprising JJ cord-023095-4dannjjm 5714 4 since since IN cord-023095-4dannjjm 5714 5 mean mean JJ cord-023095-4dannjjm 5714 6 urine urine NN cord-023095-4dannjjm 5714 7 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 5714 8 concentration concentration NN cord-023095-4dannjjm 5714 9 ( ( -LRB- cord-023095-4dannjjm 5714 10 0.36 0.36 CD cord-023095-4dannjjm 5714 11 mg mg NNP cord-023095-4dannjjm 5714 12 / / SYM cord-023095-4dannjjm 5714 13 ml ml NNP cord-023095-4dannjjm 5714 14 ) ) -RRB- cord-023095-4dannjjm 5714 15 in in IN cord-023095-4dannjjm 5714 16 dogs dog NNS cord-023095-4dannjjm 5714 17 following follow VBG cord-023095-4dannjjm 5714 18 a a DT cord-023095-4dannjjm 5714 19 modest modest JJ cord-023095-4dannjjm 5714 20 IV IV NNP cord-023095-4dannjjm 5714 21 dose dose NN cord-023095-4dannjjm 5714 22 ( ( -LRB- cord-023095-4dannjjm 5714 23 13 13 CD cord-023095-4dannjjm 5714 24 mg mg NNP cord-023095-4dannjjm 5714 25 / / SYM cord-023095-4dannjjm 5714 26 kg kg NNP cord-023095-4dannjjm 5714 27 ) ) -RRB- cord-023095-4dannjjm 5714 28 was be VBD cord-023095-4dannjjm 5714 29 3 3 CD cord-023095-4dannjjm 5714 30 times time NNS cord-023095-4dannjjm 5714 31 higher high JJR cord-023095-4dannjjm 5714 32 than than IN cord-023095-4dannjjm 5714 33 the the DT cord-023095-4dannjjm 5714 34 solubility solubility NN cord-023095-4dannjjm 5714 35 of of IN cord-023095-4dannjjm 5714 36 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 5714 37 in in IN cord-023095-4dannjjm 5714 38 water water NN cord-023095-4dannjjm 5714 39 ( ( -LRB- cord-023095-4dannjjm 5714 40 0.12 0.12 CD cord-023095-4dannjjm 5714 41 mg mg NNP cord-023095-4dannjjm 5714 42 / / SYM cord-023095-4dannjjm 5714 43 ml ml NNP cord-023095-4dannjjm 5714 44 ) ) -RRB- cord-023095-4dannjjm 5714 45 . . . cord-023095-4dannjjm 5715 1 To to TO cord-023095-4dannjjm 5715 2 identify identify VB cord-023095-4dannjjm 5715 3 the the DT cord-023095-4dannjjm 5715 4 occurrence occurrence NN cord-023095-4dannjjm 5715 5 of of IN cord-023095-4dannjjm 5715 6 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 5715 7 uroliths urolith NNS cord-023095-4dannjjm 5715 8 in in IN cord-023095-4dannjjm 5715 9 dogs dog NNS cord-023095-4dannjjm 5715 10 , , , cord-023095-4dannjjm 5715 11 records record NNS cord-023095-4dannjjm 5715 12 from from IN cord-023095-4dannjjm 5715 13 the the DT cord-023095-4dannjjm 5715 14 Minnesota Minnesota NNP cord-023095-4dannjjm 5715 15 Urolith Urolith NNP cord-023095-4dannjjm 5715 16 Center Center NNP cord-023095-4dannjjm 5715 17 were be VBD cord-023095-4dannjjm 5715 18 reviewed review VBN cord-023095-4dannjjm 5715 19 . . . cord-023095-4dannjjm 5716 1 Between between IN cord-023095-4dannjjm 5716 2 January January NNP cord-023095-4dannjjm 5716 3 2001 2001 CD cord-023095-4dannjjm 5716 4 and and CC cord-023095-4dannjjm 5716 5 December December NNP cord-023095-4dannjjm 5716 6 2009 2009 CD cord-023095-4dannjjm 5716 7 , , , cord-023095-4dannjjm 5716 8 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 5716 9 was be VBD cord-023095-4dannjjm 5716 10 identified identify VBN cord-023095-4dannjjm 5716 11 in in IN cord-023095-4dannjjm 5716 12 uroliths urolith NNS cord-023095-4dannjjm 5716 13 from from IN cord-023095-4dannjjm 5716 14 58 58 CD cord-023095-4dannjjm 5716 15 dogs dog NNS cord-023095-4dannjjm 5716 16 ; ; : cord-023095-4dannjjm 5716 17 uroliths uroliths NNP cord-023095-4dannjjm 5716 18 were be VBD cord-023095-4dannjjm 5716 19 composed compose VBN cord-023095-4dannjjm 5716 20 of of IN cord-023095-4dannjjm 5716 21 100 100 CD cord-023095-4dannjjm 5716 22 % % NN cord-023095-4dannjjm 5716 23 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 5716 24 in in IN cord-023095-4dannjjm 5716 25 10 10 CD cord-023095-4dannjjm 5716 26 , , , cord-023095-4dannjjm 5716 27 mixed mixed JJ cord-023095-4dannjjm 5716 28 uroliths urolith NNS cord-023095-4dannjjm 5716 29 containing contain VBG cord-023095-4dannjjm 5716 30 ciprofloxacin ciprofloxacin NNS cord-023095-4dannjjm 5716 31 were be VBD cord-023095-4dannjjm 5716 32 identified identify VBN cord-023095-4dannjjm 5716 33 in in IN cord-023095-4dannjjm 5716 34 6 6 CD cord-023095-4dannjjm 5716 35 , , , cord-023095-4dannjjm 5716 36 a a DT cord-023095-4dannjjm 5716 37 shell shell NN cord-023095-4dannjjm 5716 38 of of IN cord-023095-4dannjjm 5716 39 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 5716 40 was be VBD cord-023095-4dannjjm 5716 41 observed observe VBN cord-023095-4dannjjm 5716 42 in in IN cord-023095-4dannjjm 5716 43 21 21 CD cord-023095-4dannjjm 5716 44 , , , cord-023095-4dannjjm 5716 45 and and CC cord-023095-4dannjjm 5716 46 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 5716 47 surface surface NN cord-023095-4dannjjm 5716 48 crystals crystal NNS cord-023095-4dannjjm 5716 49 were be VBD cord-023095-4dannjjm 5716 50 identified identify VBN cord-023095-4dannjjm 5716 51 in in IN cord-023095-4dannjjm 5716 52 21 21 CD cord-023095-4dannjjm 5716 53 . . . cord-023095-4dannjjm 5717 1 Based base VBN cord-023095-4dannjjm 5717 2 on on IN cord-023095-4dannjjm 5717 3 an an DT cord-023095-4dannjjm 5717 4 experimental experimental JJ cord-023095-4dannjjm 5717 5 study study NN cord-023095-4dannjjm 5717 6 in in IN cord-023095-4dannjjm 5717 7 which which WDT cord-023095-4dannjjm 5717 8 83 83 CD cord-023095-4dannjjm 5717 9 % % NN cord-023095-4dannjjm 5717 10 of of IN cord-023095-4dannjjm 5717 11 human human JJ cord-023095-4dannjjm 5717 12 volunteers volunteer NNS cord-023095-4dannjjm 5717 13 consuming consume VBG cord-023095-4dannjjm 5717 14 1000 1000 CD cord-023095-4dannjjm 5717 15 mg mg NN cord-023095-4dannjjm 5717 16 of of IN cord-023095-4dannjjm 5717 17 ciprofloxacin ciprofloxacin NNP cord-023095-4dannjjm 5717 18 with with IN cord-023095-4dannjjm 5717 19 NaHCO3 NaHCO3 NNP cord-023095-4dannjjm 5717 20 exhibited exhibit VBD cord-023095-4dannjjm 5717 21 ciprofloxacin ciprofloxacin NNP cord-023095-4dannjjm 5717 22 crystalluria crystalluria NNP cord-023095-4dannjjm 5717 23 ( ( -LRB- cord-023095-4dannjjm 5717 24 urine urine NN cord-023095-4dannjjm 5717 25 pH pH NNP cord-023095-4dannjjm 5717 26 47.3 47.3 CD cord-023095-4dannjjm 5717 27 ) ) -RRB- cord-023095-4dannjjm 5717 28 , , , cord-023095-4dannjjm 5717 29 while while IN cord-023095-4dannjjm 5717 30 no no DT cord-023095-4dannjjm 5717 31 volunteers volunteer NNS cord-023095-4dannjjm 5717 32 consuming consume VBG cord-023095-4dannjjm 5717 33 1000 1000 CD cord-023095-4dannjjm 5717 34 mg mg NN cord-023095-4dannjjm 5717 35 of of IN cord-023095-4dannjjm 5717 36 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 5717 37 and and CC cord-023095-4dannjjm 5717 38 NH4Cl NH4Cl NNP cord-023095-4dannjjm 5717 39 to to TO cord-023095-4dannjjm 5717 40 acidify acidify VB cord-023095-4dannjjm 5717 41 urine urine NN cord-023095-4dannjjm 5717 42 formed form VBN cord-023095-4dannjjm 5717 43 crystals crystal NNS cord-023095-4dannjjm 5717 44 ; ; : cord-023095-4dannjjm 5717 45 we -PRON- PRP cord-023095-4dannjjm 5717 46 postulated postulate VBD cord-023095-4dannjjm 5717 47 that that IN cord-023095-4dannjjm 5717 48 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 5717 49 uroliths uroliths NNP cord-023095-4dannjjm 5717 50 could could MD cord-023095-4dannjjm 5717 51 be be VB cord-023095-4dannjjm 5717 52 dissolved dissolve VBN cord-023095-4dannjjm 5717 53 in in IN cord-023095-4dannjjm 5717 54 acidic acidic JJ cord-023095-4dannjjm 5717 55 urine urine NN cord-023095-4dannjjm 5717 56 . . . cord-023095-4dannjjm 5718 1 To to TO cord-023095-4dannjjm 5718 2 test test VB cord-023095-4dannjjm 5718 3 this this DT cord-023095-4dannjjm 5718 4 hypothesis hypothesis NN cord-023095-4dannjjm 5718 5 , , , cord-023095-4dannjjm 5718 6 canine canine JJ cord-023095-4dannjjm 5718 7 uroliths urolith NNS cord-023095-4dannjjm 5718 8 composed compose VBN cord-023095-4dannjjm 5718 9 of of IN cord-023095-4dannjjm 5718 10 100 100 CD cord-023095-4dannjjm 5718 11 % % NN cord-023095-4dannjjm 5718 12 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 5718 13 from from IN cord-023095-4dannjjm 5718 14 a a DT cord-023095-4dannjjm 5718 15 single single JJ cord-023095-4dannjjm 5718 16 source source NN cord-023095-4dannjjm 5718 17 ( ( -LRB- cord-023095-4dannjjm 5718 18 6-yr 6-yr JJ cord-023095-4dannjjm 5718 19 - - HYPH cord-023095-4dannjjm 5718 20 old old JJ cord-023095-4dannjjm 5718 21 male male NN cord-023095-4dannjjm 5718 22 , , , cord-023095-4dannjjm 5718 23 English english JJ cord-023095-4dannjjm 5718 24 bulldog bulldog NN cord-023095-4dannjjm 5718 25 receiving receive VBG cord-023095-4dannjjm 5718 26 24 24 CD cord-023095-4dannjjm 5718 27 mg mg NNP cord-023095-4dannjjm 5718 28 / / SYM cord-023095-4dannjjm 5718 29 kg kg NNS cord-023095-4dannjjm 5718 30 of of IN cord-023095-4dannjjm 5718 31 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 5718 32 PO PO NNP cord-023095-4dannjjm 5718 33 , , , cord-023095-4dannjjm 5718 34 q12 q12 NN cord-023095-4dannjjm 5718 35 hr hr NN cord-023095-4dannjjm 5718 36 to to TO cord-023095-4dannjjm 5718 37 manage manage VB cord-023095-4dannjjm 5718 38 superficial superficial JJ cord-023095-4dannjjm 5718 39 pyoderma pyoderma NNS cord-023095-4dannjjm 5718 40 ; ; , cord-023095-4dannjjm 5718 41 turbulent turbulent JJ cord-023095-4dannjjm 5718 42 flow flow NN cord-023095-4dannjjm 5718 43 chromatography chromatography NN cord-023095-4dannjjm 5718 44 / / SYM cord-023095-4dannjjm 5718 45 tandem tandem NN cord-023095-4dannjjm 5718 46 mass mass NN cord-023095-4dannjjm 5718 47 spectrometry spectrometry NN cord-023095-4dannjjm 5718 48 detected detect VBD cord-023095-4dannjjm 5718 49 517 517 CD cord-023095-4dannjjm 5718 50 mg mg NN cord-023095-4dannjjm 5718 51 of of IN cord-023095-4dannjjm 5718 52 ciprofloxacin ciprofloxacin NNP cord-023095-4dannjjm 5718 53 / / SYM cord-023095-4dannjjm 5718 54 g g NN cord-023095-4dannjjm 5718 55 of of IN cord-023095-4dannjjm 5718 56 urolith urolith NN cord-023095-4dannjjm 5718 57 ) ) -RRB- cord-023095-4dannjjm 5718 58 were be VBD cord-023095-4dannjjm 5718 59 incubated incubate VBN cord-023095-4dannjjm 5718 60 in in IN cord-023095-4dannjjm 5718 61 urine urine NN cord-023095-4dannjjm 5718 62 at at IN cord-023095-4dannjjm 5718 63 selected select VBN cord-023095-4dannjjm 5718 64 pH pH NNP cord-023095-4dannjjm 5718 65 's 's POS cord-023095-4dannjjm 5718 66 and and CC cord-023095-4dannjjm 5718 67 monitored monitor VBN cord-023095-4dannjjm 5718 68 for for IN cord-023095-4dannjjm 5718 69 dissolution dissolution NN cord-023095-4dannjjm 5718 70 . . . cord-023095-4dannjjm 5719 1 Urine urine NN cord-023095-4dannjjm 5719 2 obtained obtain VBN cord-023095-4dannjjm 5719 3 from from IN cord-023095-4dannjjm 5719 4 multiple multiple JJ cord-023095-4dannjjm 5719 5 dogs dog NNS cord-023095-4dannjjm 5719 6 not not RB cord-023095-4dannjjm 5719 7 receiving receive VBG cord-023095-4dannjjm 5719 8 fluoroquinolones fluoroquinolone NNS cord-023095-4dannjjm 5719 9 , , , cord-023095-4dannjjm 5719 10 was be VBD cord-023095-4dannjjm 5719 11 pooled pool VBN cord-023095-4dannjjm 5719 12 and and CC cord-023095-4dannjjm 5719 13 divided divide VBN cord-023095-4dannjjm 5719 14 into into IN cord-023095-4dannjjm 5719 15 5 5 CD cord-023095-4dannjjm 5719 16 aliquots aliquot NNS cord-023095-4dannjjm 5719 17 . . . cord-023095-4dannjjm 5720 1 Aliquots aliquot NNS cord-023095-4dannjjm 5720 2 were be VBD cord-023095-4dannjjm 5720 3 adjusted adjust VBN cord-023095-4dannjjm 5720 4 with with IN cord-023095-4dannjjm 5720 5 HCl HCl NNP cord-023095-4dannjjm 5720 6 or or CC cord-023095-4dannjjm 5720 7 NaOH NaOH NNP cord-023095-4dannjjm 5720 8 to to IN cord-023095-4dannjjm 5720 9 a a DT cord-023095-4dannjjm 5720 10 pH ph NN cord-023095-4dannjjm 5720 11 of of IN cord-023095-4dannjjm 5720 12 3 3 CD cord-023095-4dannjjm 5720 13 , , , cord-023095-4dannjjm 5720 14 5 5 CD cord-023095-4dannjjm 5720 15 , , , cord-023095-4dannjjm 5720 16 6 6 CD cord-023095-4dannjjm 5720 17 , , , cord-023095-4dannjjm 5720 18 7 7 CD cord-023095-4dannjjm 5720 19 , , , cord-023095-4dannjjm 5720 20 or or CC cord-023095-4dannjjm 5720 21 8 8 CD cord-023095-4dannjjm 5720 22 . . . cord-023095-4dannjjm 5721 1 Aliquots Aliquots NNP cord-023095-4dannjjm 5721 2 were be VBD cord-023095-4dannjjm 5721 3 capped cap VBN cord-023095-4dannjjm 5721 4 and and CC cord-023095-4dannjjm 5721 5 preserved preserve VBN cord-023095-4dannjjm 5721 6 by by IN cord-023095-4dannjjm 5721 7 refrigeration refrigeration NN cord-023095-4dannjjm 5721 8 ; ; : cord-023095-4dannjjm 5721 9 pH pH NNP cord-023095-4dannjjm 5721 10 was be VBD cord-023095-4dannjjm 5721 11 monitored monitor VBN cord-023095-4dannjjm 5721 12 and and CC cord-023095-4dannjjm 5721 13 readjusted readjust VBN cord-023095-4dannjjm 5721 14 weekly weekly RB cord-023095-4dannjjm 5721 15 . . . cord-023095-4dannjjm 5722 1 Ten ten CD cord-023095-4dannjjm 5722 2 uroliths urolith NNS cord-023095-4dannjjm 5722 3 of of IN cord-023095-4dannjjm 5722 4 approximately approximately RB cord-023095-4dannjjm 5722 5 equal equal JJ cord-023095-4dannjjm 5722 6 weight weight NN cord-023095-4dannjjm 5722 7 were be VBD cord-023095-4dannjjm 5722 8 randomly randomly RB cord-023095-4dannjjm 5722 9 assigned assign VBN cord-023095-4dannjjm 5722 10 to to IN cord-023095-4dannjjm 5722 11 individual individual JJ cord-023095-4dannjjm 5722 12 flasks flask NNS cord-023095-4dannjjm 5722 13 containing contain VBG cord-023095-4dannjjm 5722 14 10 10 CD cord-023095-4dannjjm 5722 15 mls mls NN cord-023095-4dannjjm 5722 16 of of IN cord-023095-4dannjjm 5722 17 urine urine NN cord-023095-4dannjjm 5722 18 . . . cord-023095-4dannjjm 5723 1 Flasks flask NNS cord-023095-4dannjjm 5723 2 were be VBD cord-023095-4dannjjm 5723 3 constantly constantly RB cord-023095-4dannjjm 5723 4 agitated agitate VBN cord-023095-4dannjjm 5723 5 and and CC cord-023095-4dannjjm 5723 6 maintained maintain VBN cord-023095-4dannjjm 5723 7 at at IN cord-023095-4dannjjm 5723 8 381C. 381c. CD cord-023095-4dannjjm 5723 9 Every every DT cord-023095-4dannjjm 5723 10 24 24 CD cord-023095-4dannjjm 5723 11 hours hour NNS cord-023095-4dannjjm 5723 12 , , , cord-023095-4dannjjm 5723 13 urine urine NN cord-023095-4dannjjm 5723 14 was be VBD cord-023095-4dannjjm 5723 15 discarded discard VBN cord-023095-4dannjjm 5723 16 and and CC cord-023095-4dannjjm 5723 17 replaced replace VBN cord-023095-4dannjjm 5723 18 with with IN cord-023095-4dannjjm 5723 19 10 10 CD cord-023095-4dannjjm 5723 20 mls mls NN cord-023095-4dannjjm 5723 21 of of IN cord-023095-4dannjjm 5723 22 urine urine NN cord-023095-4dannjjm 5723 23 of of IN cord-023095-4dannjjm 5723 24 identical identical JJ cord-023095-4dannjjm 5723 25 pH ph NN cord-023095-4dannjjm 5723 26 until until IN cord-023095-4dannjjm 5723 27 stone stone NN cord-023095-4dannjjm 5723 28 dissolution dissolution NN cord-023095-4dannjjm 5723 29 was be VBD cord-023095-4dannjjm 5723 30 complete complete JJ cord-023095-4dannjjm 5723 31 . . . cord-023095-4dannjjm 5724 1 Ciprofloxacin Ciprofloxacin NNP cord-023095-4dannjjm 5724 2 urolith urolith NN cord-023095-4dannjjm 5724 3 dissolution dissolution NN cord-023095-4dannjjm 5724 4 times time NNS cord-023095-4dannjjm 5724 5 at at IN cord-023095-4dannjjm 5724 6 each each DT cord-023095-4dannjjm 5724 7 urine urine NN cord-023095-4dannjjm 5725 1 pH pH NNP cord-023095-4dannjjm 5725 2 are be VBP cord-023095-4dannjjm 5725 3 reported report VBN cord-023095-4dannjjm 5725 4 below below RB cord-023095-4dannjjm 5725 5 . . . cord-023095-4dannjjm 5726 1 Ciprofloxacin Ciprofloxacin NNP cord-023095-4dannjjm 5726 2 uroliths urolith NNS cord-023095-4dannjjm 5726 3 are be VBP cord-023095-4dannjjm 5726 4 a a DT cord-023095-4dannjjm 5726 5 newly newly RB cord-023095-4dannjjm 5726 6 recognized recognize VBN cord-023095-4dannjjm 5726 7 disease disease NN cord-023095-4dannjjm 5726 8 and and CC cord-023095-4dannjjm 5726 9 a a DT cord-023095-4dannjjm 5726 10 potential potential JJ cord-023095-4dannjjm 5726 11 adverse adverse JJ cord-023095-4dannjjm 5726 12 effect effect NN cord-023095-4dannjjm 5726 13 of of IN cord-023095-4dannjjm 5726 14 ciprofloxacin ciprofloxacin NNP cord-023095-4dannjjm 5726 15 administration administration NN cord-023095-4dannjjm 5726 16 in in IN cord-023095-4dannjjm 5726 17 dogs dog NNS cord-023095-4dannjjm 5726 18 . . . cord-023095-4dannjjm 5727 1 In in IN cord-023095-4dannjjm 5727 2 vitro vitro FW cord-023095-4dannjjm 5727 3 dissolution dissolution NN cord-023095-4dannjjm 5727 4 of of IN cord-023095-4dannjjm 5727 5 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 5727 6 uroliths uroliths NNP cord-023095-4dannjjm 5727 7 was be VBD cord-023095-4dannjjm 5727 8 achieved achieve VBN cord-023095-4dannjjm 5727 9 in in IN cord-023095-4dannjjm 5727 10 canine canine JJ cord-023095-4dannjjm 5727 11 urine urine NN cord-023095-4dannjjm 5727 12 , , , cord-023095-4dannjjm 5727 13 supporting support VBG cord-023095-4dannjjm 5727 14 the the DT cord-023095-4dannjjm 5727 15 premise premise NN cord-023095-4dannjjm 5727 16 that that IN cord-023095-4dannjjm 5727 17 in in IN cord-023095-4dannjjm 5727 18 vivo vivo NNP cord-023095-4dannjjm 5727 19 dissolution dissolution NN cord-023095-4dannjjm 5727 20 is be VBZ cord-023095-4dannjjm 5727 21 possible possible JJ cord-023095-4dannjjm 5727 22 . . . cord-023095-4dannjjm 5728 1 Urolith Urolith NNP cord-023095-4dannjjm 5728 2 dissolution dissolution NN cord-023095-4dannjjm 5728 3 times time NNS cord-023095-4dannjjm 5728 4 were be VBD cord-023095-4dannjjm 5728 5 shortest shortest RBS cord-023095-4dannjjm 5728 6 at at IN cord-023095-4dannjjm 5728 7 lower low JJR cord-023095-4dannjjm 5728 8 and and CC cord-023095-4dannjjm 5728 9 higher high JJR cord-023095-4dannjjm 5728 10 pH pH NNP cord-023095-4dannjjm 5728 11 's 's POS cord-023095-4dannjjm 5728 12 , , , cord-023095-4dannjjm 5728 13 which which WDT cord-023095-4dannjjm 5728 14 is be VBZ cord-023095-4dannjjm 5728 15 consistent consistent JJ cord-023095-4dannjjm 5728 16 with with IN cord-023095-4dannjjm 5728 17 the the DT cord-023095-4dannjjm 5728 18 pKa pKa NNPS cord-023095-4dannjjm 5728 19 ( ( -LRB- cord-023095-4dannjjm 5728 20 6.0 6.0 CD cord-023095-4dannjjm 5728 21 and and CC cord-023095-4dannjjm 5728 22 8.8 8.8 CD cord-023095-4dannjjm 5728 23 ) ) -RRB- cord-023095-4dannjjm 5728 24 of of IN cord-023095-4dannjjm 5728 25 this this DT cord-023095-4dannjjm 5728 26 amphiprotic amphiprotic JJ cord-023095-4dannjjm 5728 27 antimicrobic antimicrobic NNP cord-023095-4dannjjm 5728 28 ( ( -LRB- cord-023095-4dannjjm 5728 29 more more RBR cord-023095-4dannjjm 5728 30 soluble soluble JJ cord-023095-4dannjjm 5728 31 at at IN cord-023095-4dannjjm 5728 32 pH ph NN cord-023095-4dannjjm 5728 33 below below IN cord-023095-4dannjjm 5728 34 the the DT cord-023095-4dannjjm 5728 35 acidic acidic JJ cord-023095-4dannjjm 5728 36 pKa pKa NNPS cord-023095-4dannjjm 5728 37 and and CC cord-023095-4dannjjm 5728 38 above above IN cord-023095-4dannjjm 5728 39 the the DT cord-023095-4dannjjm 5728 40 alkaline alkaline JJ cord-023095-4dannjjm 5728 41 pKa pKa NNP cord-023095-4dannjjm 5728 42 ) ) -RRB- cord-023095-4dannjjm 5728 43 . . . cord-023095-4dannjjm 5729 1 Foods food NNS cord-023095-4dannjjm 5729 2 designed design VBN cord-023095-4dannjjm 5729 3 to to TO cord-023095-4dannjjm 5729 4 promote promote VB cord-023095-4dannjjm 5729 5 struvite struvite NN cord-023095-4dannjjm 5729 6 urolith urolith NN cord-023095-4dannjjm 5729 7 dissolution dissolution NN cord-023095-4dannjjm 5729 8 may may MD cord-023095-4dannjjm 5729 9 be be VB cord-023095-4dannjjm 5729 10 designed design VBN cord-023095-4dannjjm 5729 11 for for IN cord-023095-4dannjjm 5729 12 short short JJ cord-023095-4dannjjm 5729 13 term term NN cord-023095-4dannjjm 5729 14 feeding feed VBG cord-023095-4dannjjm 5729 15 facilitating facilitate VBG cord-023095-4dannjjm 5729 16 rapid rapid JJ cord-023095-4dannjjm 5729 17 dissolution dissolution NN cord-023095-4dannjjm 5729 18 or or CC cord-023095-4dannjjm 5729 19 may may MD cord-023095-4dannjjm 5729 20 be be VB cord-023095-4dannjjm 5729 21 formulated formulate VBN cord-023095-4dannjjm 5729 22 with with IN cord-023095-4dannjjm 5729 23 a a DT cord-023095-4dannjjm 5729 24 more more RBR cord-023095-4dannjjm 5729 25 moderate moderate JJ cord-023095-4dannjjm 5729 26 target target NN cord-023095-4dannjjm 5729 27 urine urine NN cord-023095-4dannjjm 5729 28 pH ph NN cord-023095-4dannjjm 5729 29 to to TO cord-023095-4dannjjm 5729 30 allow allow VB cord-023095-4dannjjm 5729 31 for for IN cord-023095-4dannjjm 5729 32 dissolution dissolution NN cord-023095-4dannjjm 5729 33 and and CC cord-023095-4dannjjm 5729 34 then then RB cord-023095-4dannjjm 5729 35 life life NN cord-023095-4dannjjm 5729 36 - - HYPH cord-023095-4dannjjm 5729 37 long long JJ cord-023095-4dannjjm 5729 38 maintenance maintenance NN cord-023095-4dannjjm 5729 39 feeding feeding NN cord-023095-4dannjjm 5729 40 minimizing minimize VBG cord-023095-4dannjjm 5729 41 recurrence recurrence NN cord-023095-4dannjjm 5729 42 . . . cord-023095-4dannjjm 5730 1 The the DT cord-023095-4dannjjm 5730 2 purpose purpose NN cord-023095-4dannjjm 5730 3 of of IN cord-023095-4dannjjm 5730 4 this this DT cord-023095-4dannjjm 5730 5 study study NN cord-023095-4dannjjm 5730 6 was be VBD cord-023095-4dannjjm 5730 7 to to TO cord-023095-4dannjjm 5730 8 compare compare VB cord-023095-4dannjjm 5730 9 the the DT cord-023095-4dannjjm 5730 10 efficacy efficacy NN cord-023095-4dannjjm 5730 11 and and CC cord-023095-4dannjjm 5730 12 rate rate NN cord-023095-4dannjjm 5730 13 of of IN cord-023095-4dannjjm 5730 14 dissolution dissolution NN cord-023095-4dannjjm 5730 15 of of IN cord-023095-4dannjjm 5730 16 a a DT cord-023095-4dannjjm 5730 17 maintenance maintenance NN cord-023095-4dannjjm 5730 18 food food NN cord-023095-4dannjjm 5730 19 with with IN cord-023095-4dannjjm 5730 20 a a DT cord-023095-4dannjjm 5730 21 struvite struvite NN cord-023095-4dannjjm 5730 22 dissolution dissolution NN cord-023095-4dannjjm 5730 23 food food NN cord-023095-4dannjjm 5730 24 . . . cord-023095-4dannjjm 5731 1 Sixteen sixteen CD cord-023095-4dannjjm 5731 2 client client NN cord-023095-4dannjjm 5731 3 - - HYPH cord-023095-4dannjjm 5731 4 owned own VBN cord-023095-4dannjjm 5731 5 adult adult NN cord-023095-4dannjjm 5731 6 cats cat NNS cord-023095-4dannjjm 5731 7 ( ( -LRB- cord-023095-4dannjjm 5731 8 13 13 CD cord-023095-4dannjjm 5731 9 FS fs NN cord-023095-4dannjjm 5731 10 , , , cord-023095-4dannjjm 5731 11 3 3 CD cord-023095-4dannjjm 5731 12 MC MC NNP cord-023095-4dannjjm 5731 13 ) ) -RRB- cord-023095-4dannjjm 5731 14 with with IN cord-023095-4dannjjm 5731 15 naturally naturally RB cord-023095-4dannjjm 5731 16 occurring occur VBG cord-023095-4dannjjm 5731 17 struvite struvite NN cord-023095-4dannjjm 5731 18 urocystoliths urocystolith NNS cord-023095-4dannjjm 5731 19 ( ( -LRB- cord-023095-4dannjjm 5731 20 mineral mineral NN cord-023095-4dannjjm 5731 21 composition composition NN cord-023095-4dannjjm 5731 22 based base VBN cord-023095-4dannjjm 5731 23 on on IN cord-023095-4dannjjm 5731 24 history history NN cord-023095-4dannjjm 5731 25 , , , cord-023095-4dannjjm 5731 26 radiographs radiograph NNS cord-023095-4dannjjm 5731 27 , , , cord-023095-4dannjjm 5731 28 urinalysis urinalysis NN cord-023095-4dannjjm 5731 29 , , , cord-023095-4dannjjm 5731 30 urine urine NN cord-023095-4dannjjm 5731 31 culture culture NN cord-023095-4dannjjm 5731 32 and and CC cord-023095-4dannjjm 5731 33 physical physical JJ cord-023095-4dannjjm 5731 34 examination examination NN cord-023095-4dannjjm 5731 35 ) ) -RRB- cord-023095-4dannjjm 5731 36 were be VBD cord-023095-4dannjjm 5731 37 randomized randomize VBN cord-023095-4dannjjm 5731 38 to to IN cord-023095-4dannjjm 5731 39 either either CC cord-023095-4dannjjm 5731 40 a a DT cord-023095-4dannjjm 5731 41 dry dry JJ cord-023095-4dannjjm 5731 42 maintenance maintenance NN cord-023095-4dannjjm 5731 43 food food NN cord-023095-4dannjjm 5731 44 ( ( -LRB- cord-023095-4dannjjm 5731 45 Test test NN cord-023095-4dannjjm 5731 46 ) ) -RRB- cord-023095-4dannjjm 5731 47 or or CC cord-023095-4dannjjm 5731 48 a a DT cord-023095-4dannjjm 5731 49 dry dry JJ cord-023095-4dannjjm 5731 50 food food NN cord-023095-4dannjjm 5731 51 known know VBN cord-023095-4dannjjm 5731 52 to to TO cord-023095-4dannjjm 5731 53 dissolve dissolve VB cord-023095-4dannjjm 5731 54 struvite struvite NN cord-023095-4dannjjm 5731 55 uroliths urolith NNS cord-023095-4dannjjm 5731 56 ( ( -LRB- cord-023095-4dannjjm 5731 57 Control Control NNP cord-023095-4dannjjm 5731 58 ) ) -RRB- cord-023095-4dannjjm 5731 59 . . . cord-023095-4dannjjm 5732 1 The the DT cord-023095-4dannjjm 5732 2 clinical clinical JJ cord-023095-4dannjjm 5732 3 care care NN cord-023095-4dannjjm 5732 4 team team NN cord-023095-4dannjjm 5732 5 and and CC cord-023095-4dannjjm 5732 6 owner owner NN cord-023095-4dannjjm 5732 7 were be VBD cord-023095-4dannjjm 5732 8 blinded blind VBN cord-023095-4dannjjm 5732 9 to to IN cord-023095-4dannjjm 5732 10 treatment treatment NN cord-023095-4dannjjm 5732 11 assignment assignment NN cord-023095-4dannjjm 5732 12 . . . cord-023095-4dannjjm 5733 1 The the DT cord-023095-4dannjjm 5733 2 Test test NN cord-023095-4dannjjm 5733 3 food food NN cord-023095-4dannjjm 5733 4 was be VBD cord-023095-4dannjjm 5733 5 formulated formulate VBN cord-023095-4dannjjm 5733 6 to to TO cord-023095-4dannjjm 5733 7 provide provide VB cord-023095-4dannjjm 5733 8 0.06 0.06 CD cord-023095-4dannjjm 5733 9 % % NN cord-023095-4dannjjm 5733 10 Mg Mg NNP cord-023095-4dannjjm 5733 11 ( ( -LRB- cord-023095-4dannjjm 5733 12 DM DM NNP cord-023095-4dannjjm 5733 13 ) ) -RRB- cord-023095-4dannjjm 5733 14 , , , cord-023095-4dannjjm 5733 15 0.65 0.65 CD cord-023095-4dannjjm 5733 16 % % NN cord-023095-4dannjjm 5733 17 P p NN cord-023095-4dannjjm 5733 18 , , , cord-023095-4dannjjm 5733 19 35 35 CD cord-023095-4dannjjm 5733 20 % % NN cord-023095-4dannjjm 5733 21 protein protein NN cord-023095-4dannjjm 5733 22 , , , cord-023095-4dannjjm 5733 23 and and CC cord-023095-4dannjjm 5733 24 a a DT cord-023095-4dannjjm 5733 25 calculated calculate VBN cord-023095-4dannjjm 5733 26 target target NN cord-023095-4dannjjm 5733 27 urine urine NN cord-023095-4dannjjm 5733 28 pH pH NNP cord-023095-4dannjjm 5733 29 value value NN cord-023095-4dannjjm 5733 30 ( ( -LRB- cord-023095-4dannjjm 5733 31 UpH UpH NNP cord-023095-4dannjjm 5733 32 ) ) -RRB- cord-023095-4dannjjm 5733 33 of of IN cord-023095-4dannjjm 5733 34 6.2 6.2 CD cord-023095-4dannjjm 5733 35 - - SYM cord-023095-4dannjjm 5733 36 6.4 6.4 CD cord-023095-4dannjjm 5733 37 . . . cord-023095-4dannjjm 5734 1 The the DT cord-023095-4dannjjm 5734 2 Control Control NNP cord-023095-4dannjjm 5734 3 food food NN cord-023095-4dannjjm 5734 4 was be VBD cord-023095-4dannjjm 5734 5 formulated formulate VBN cord-023095-4dannjjm 5734 6 to to TO cord-023095-4dannjjm 5734 7 provide provide VB cord-023095-4dannjjm 5734 8 0.06 0.06 CD cord-023095-4dannjjm 5734 9 % % NN cord-023095-4dannjjm 5734 10 Mg Mg NNP cord-023095-4dannjjm 5734 11 ( ( -LRB- cord-023095-4dannjjm 5734 12 DM DM NNP cord-023095-4dannjjm 5734 13 ) ) -RRB- cord-023095-4dannjjm 5734 14 , , , cord-023095-4dannjjm 5734 15 0.77 0.77 CD cord-023095-4dannjjm 5734 16 % % NN cord-023095-4dannjjm 5734 17 P p NN cord-023095-4dannjjm 5734 18 , , , cord-023095-4dannjjm 5734 19 35 35 CD cord-023095-4dannjjm 5734 20 % % NN cord-023095-4dannjjm 5734 21 protein protein NN cord-023095-4dannjjm 5734 22 , , , cord-023095-4dannjjm 5734 23 and and CC cord-023095-4dannjjm 5734 24 a a DT cord-023095-4dannjjm 5734 25 targeted target VBN cord-023095-4dannjjm 5734 26 urine urine NN cord-023095-4dannjjm 5734 27 pH ph NN cord-023095-4dannjjm 5734 28 of of IN cord-023095-4dannjjm 5734 29 5.9 5.9 CD cord-023095-4dannjjm 5734 30 - - SYM cord-023095-4dannjjm 5734 31 6.1 6.1 CD cord-023095-4dannjjm 5734 32 . . . cord-023095-4dannjjm 5735 1 Owners owner NNS cord-023095-4dannjjm 5735 2 were be VBD cord-023095-4dannjjm 5735 3 advised advise VBN cord-023095-4dannjjm 5735 4 to to TO cord-023095-4dannjjm 5735 5 feed feed VB cord-023095-4dannjjm 5735 6 the the DT cord-023095-4dannjjm 5735 7 assigned assign VBN cord-023095-4dannjjm 5735 8 diet diet NN cord-023095-4dannjjm 5735 9 exclusively exclusively RB cord-023095-4dannjjm 5735 10 in in IN cord-023095-4dannjjm 5735 11 an an DT cord-023095-4dannjjm 5735 12 amount amount NN cord-023095-4dannjjm 5735 13 to to TO cord-023095-4dannjjm 5735 14 maintain maintain VB cord-023095-4dannjjm 5735 15 body body NN cord-023095-4dannjjm 5735 16 condition condition NN cord-023095-4dannjjm 5735 17 . . . cord-023095-4dannjjm 5736 1 After after IN cord-023095-4dannjjm 5736 2 diet diet NN cord-023095-4dannjjm 5736 3 assignment assignment NN cord-023095-4dannjjm 5736 4 radiographs radiograph NNS cord-023095-4dannjjm 5736 5 were be VBD cord-023095-4dannjjm 5736 6 performed perform VBN cord-023095-4dannjjm 5736 7 at at IN cord-023095-4dannjjm 5736 8 eight eight CD cord-023095-4dannjjm 5736 9 weekly weekly JJ cord-023095-4dannjjm 5736 10 intervals interval NNS cord-023095-4dannjjm 5736 11 until until IN cord-023095-4dannjjm 5736 12 there there EX cord-023095-4dannjjm 5736 13 was be VBD cord-023095-4dannjjm 5736 14 no no DT cord-023095-4dannjjm 5736 15 evidence evidence NN cord-023095-4dannjjm 5736 16 of of IN cord-023095-4dannjjm 5736 17 uroliths urolith NNS cord-023095-4dannjjm 5736 18 or or CC cord-023095-4dannjjm 5736 19 until until IN cord-023095-4dannjjm 5736 20 there there EX cord-023095-4dannjjm 5736 21 was be VBD cord-023095-4dannjjm 5736 22 evidence evidence NN cord-023095-4dannjjm 5736 23 that that IN cord-023095-4dannjjm 5736 24 the the DT cord-023095-4dannjjm 5736 25 uroliths urolith NNS cord-023095-4dannjjm 5736 26 were be VBD cord-023095-4dannjjm 5736 27 the the DT cord-023095-4dannjjm 5736 28 same same JJ cord-023095-4dannjjm 5736 29 size size NN cord-023095-4dannjjm 5736 30 or or CC cord-023095-4dannjjm 5736 31 larger large JJR cord-023095-4dannjjm 5736 32 . . . cord-023095-4dannjjm 5737 1 A a DT cord-023095-4dannjjm 5737 2 physical physical JJ cord-023095-4dannjjm 5737 3 examination examination NN cord-023095-4dannjjm 5737 4 , , , cord-023095-4dannjjm 5737 5 complete complete JJ cord-023095-4dannjjm 5737 6 blood blood NN cord-023095-4dannjjm 5737 7 count count NN cord-023095-4dannjjm 5737 8 , , , cord-023095-4dannjjm 5737 9 serum serum NN cord-023095-4dannjjm 5737 10 chemistry chemistry NN cord-023095-4dannjjm 5737 11 profile profile NN cord-023095-4dannjjm 5737 12 , , , cord-023095-4dannjjm 5737 13 urinalysis urinalysis NN cord-023095-4dannjjm 5737 14 and and CC cord-023095-4dannjjm 5737 15 urine urine NN cord-023095-4dannjjm 5737 16 culture culture NN cord-023095-4dannjjm 5737 17 were be VBD cord-023095-4dannjjm 5737 18 repeated repeat VBN cord-023095-4dannjjm 5737 19 at at IN cord-023095-4dannjjm 5737 20 the the DT cord-023095-4dannjjm 5737 21 conclusion conclusion NN cord-023095-4dannjjm 5737 22 of of IN cord-023095-4dannjjm 5737 23 the the DT cord-023095-4dannjjm 5737 24 study study NN cord-023095-4dannjjm 5737 25 . . . cord-023095-4dannjjm 5738 1 Statistical statistical JJ cord-023095-4dannjjm 5738 2 analysis analysis NN cord-023095-4dannjjm 5738 3 was be VBD cord-023095-4dannjjm 5738 4 by by IN cord-023095-4dannjjm 5738 5 ANOVA ANOVA NNP cord-023095-4dannjjm 5738 6 . . . cord-023095-4dannjjm 5739 1 All all DT cord-023095-4dannjjm 5739 2 uroliths urolith NNS cord-023095-4dannjjm 5739 3 dissolved dissolve VBN cord-023095-4dannjjm 5739 4 in in IN cord-023095-4dannjjm 5739 5 all all DT cord-023095-4dannjjm 5739 6 cats cat NNS cord-023095-4dannjjm 5739 7 and and CC cord-023095-4dannjjm 5739 8 both both DT cord-023095-4dannjjm 5739 9 foods food NNS cord-023095-4dannjjm 5739 10 were be VBD cord-023095-4dannjjm 5739 11 palatable palatable JJ cord-023095-4dannjjm 5739 12 . . . cord-023095-4dannjjm 5740 1 Radiographs radiograph NNS cord-023095-4dannjjm 5740 2 of of IN cord-023095-4dannjjm 5740 3 cats cat NNS cord-023095-4dannjjm 5740 4 fed feed VBD cord-023095-4dannjjm 5740 5 the the DT cord-023095-4dannjjm 5740 6 Control Control NNP cord-023095-4dannjjm 5740 7 food food NN cord-023095-4dannjjm 5740 8 indicated indicate VBD cord-023095-4dannjjm 5740 9 the the DT cord-023095-4dannjjm 5740 10 uroliths urolith NNS cord-023095-4dannjjm 5740 11 dissolved dissolve VBN cord-023095-4dannjjm 5740 12 in in IN cord-023095-4dannjjm 5740 13 a a DT cord-023095-4dannjjm 5740 14 significantly significantly RB cord-023095-4dannjjm 5740 15 shorter short JJR cord-023095-4dannjjm 5740 16 time time NN cord-023095-4dannjjm 5740 17 ( ( -LRB- cord-023095-4dannjjm 5740 18 mean mean VB cord-023095-4dannjjm 5740 19 AE AE NNP cord-023095-4dannjjm 5740 20 Std Std NNP cord-023095-4dannjjm 5740 21 Dev Dev NNP cord-023095-4dannjjm 5740 22 of of IN cord-023095-4dannjjm 5740 23 1.6 1.6 CD cord-023095-4dannjjm 5740 24 AE AE NNP cord-023095-4dannjjm 5740 25 0.7 0.7 CD cord-023095-4dannjjm 5740 26 weeks week NNS cord-023095-4dannjjm 5740 27 ) ) -RRB- cord-023095-4dannjjm 5740 28 compared compare VBN cord-023095-4dannjjm 5740 29 to to IN cord-023095-4dannjjm 5740 30 cats cat NNS cord-023095-4dannjjm 5740 31 consuming consume VBG cord-023095-4dannjjm 5740 32 the the DT cord-023095-4dannjjm 5740 33 Test test NN cord-023095-4dannjjm 5740 34 food food NN cord-023095-4dannjjm 5740 35 ( ( -LRB- cord-023095-4dannjjm 5740 36 mean mean VB cord-023095-4dannjjm 5740 37 3.9 3.9 CD cord-023095-4dannjjm 5740 38 AE AE NNP cord-023095-4dannjjm 5740 39 2 2 CD cord-023095-4dannjjm 5740 40 weeks week NNS cord-023095-4dannjjm 5740 41 ; ; : cord-023095-4dannjjm 5740 42 Po0.05 Po0.05 NNP cord-023095-4dannjjm 5740 43 ) ) -RRB- cord-023095-4dannjjm 5740 44 . . . cord-023095-4dannjjm 5740 45 ) ) -RRB- cord-023095-4dannjjm 5740 46 . . . cord-023095-4dannjjm 5741 1 Cats cat NNS cord-023095-4dannjjm 5741 2 in in IN cord-023095-4dannjjm 5741 3 the the DT cord-023095-4dannjjm 5741 4 Control Control NNP cord-023095-4dannjjm 5741 5 group group NN cord-023095-4dannjjm 5741 6 finished finish VBD cord-023095-4dannjjm 5741 7 the the DT cord-023095-4dannjjm 5741 8 study study NN cord-023095-4dannjjm 5741 9 at at IN cord-023095-4dannjjm 5741 10 1 1 CD cord-023095-4dannjjm 5741 11 ( ( -LRB- cord-023095-4dannjjm 5741 12 n n NN cord-023095-4dannjjm 5741 13 5 5 CD cord-023095-4dannjjm 5741 14 4 4 CD cord-023095-4dannjjm 5741 15 ) ) -RRB- cord-023095-4dannjjm 5741 16 , , , cord-023095-4dannjjm 5741 17 2 2 CD cord-023095-4dannjjm 5741 18 ( ( -LRB- cord-023095-4dannjjm 5741 19 n n NN cord-023095-4dannjjm 5741 20 5 5 CD cord-023095-4dannjjm 5741 21 3 3 CD cord-023095-4dannjjm 5741 22 ) ) -RRB- cord-023095-4dannjjm 5741 23 and and CC cord-023095-4dannjjm 5741 24 3 3 CD cord-023095-4dannjjm 5741 25 weeks week NNS cord-023095-4dannjjm 5741 26 . . . cord-023095-4dannjjm 5742 1 Cats cat NNS cord-023095-4dannjjm 5742 2 in in IN cord-023095-4dannjjm 5742 3 the the DT cord-023095-4dannjjm 5742 4 Test test NN cord-023095-4dannjjm 5742 5 group group NN cord-023095-4dannjjm 5742 6 finished finish VBD cord-023095-4dannjjm 5742 7 the the DT cord-023095-4dannjjm 5742 8 study study NN cord-023095-4dannjjm 5742 9 1 1 CD cord-023095-4dannjjm 5742 10 , , , cord-023095-4dannjjm 5742 11 2 2 CD cord-023095-4dannjjm 5742 12 , , , cord-023095-4dannjjm 5742 13 3 3 CD cord-023095-4dannjjm 5742 14 ( ( -LRB- cord-023095-4dannjjm 5742 15 n n NN cord-023095-4dannjjm 5742 16 5 5 CD cord-023095-4dannjjm 5742 17 2 2 CD cord-023095-4dannjjm 5742 18 ) ) -RRB- cord-023095-4dannjjm 5742 19 , , , cord-023095-4dannjjm 5742 20 4 4 CD cord-023095-4dannjjm 5742 21 , , , cord-023095-4dannjjm 5742 22 5 5 CD cord-023095-4dannjjm 5742 23 , , , cord-023095-4dannjjm 5742 24 6 6 CD cord-023095-4dannjjm 5742 25 , , , cord-023095-4dannjjm 5742 26 and and CC cord-023095-4dannjjm 5742 27 7 7 CD cord-023095-4dannjjm 5742 28 weeks week NNS cord-023095-4dannjjm 5742 29 . . . cord-023095-4dannjjm 5743 1 All all PDT cord-023095-4dannjjm 5743 2 The the DT cord-023095-4dannjjm 5743 3 Minnesota Minnesota NNP cord-023095-4dannjjm 5743 4 Urolith Urolith NNP cord-023095-4dannjjm 5743 5 Center Center NNP cord-023095-4dannjjm 5743 6 occasionally occasionally RB cord-023095-4dannjjm 5743 7 receives receive VBZ cord-023095-4dannjjm 5743 8 uroliths uroliths NNP cord-023095-4dannjjm 5743 9 for for IN cord-023095-4dannjjm 5743 10 analysis analysis NN cord-023095-4dannjjm 5743 11 that that WDT cord-023095-4dannjjm 5743 12 are be VBP cord-023095-4dannjjm 5743 13 immersed immerse VBN cord-023095-4dannjjm 5743 14 in in IN cord-023095-4dannjjm 5743 15 formalin formalin NN cord-023095-4dannjjm 5743 16 . . . cord-023095-4dannjjm 5744 1 Results result NNS cord-023095-4dannjjm 5744 2 of of IN cord-023095-4dannjjm 5744 3 quantitative quantitative JJ cord-023095-4dannjjm 5744 4 analysis analysis NN cord-023095-4dannjjm 5744 5 of of IN cord-023095-4dannjjm 5744 6 these these DT cord-023095-4dannjjm 5744 7 uroliths urolith NNS cord-023095-4dannjjm 5744 8 revealed reveal VBD cord-023095-4dannjjm 5744 9 that that IN cord-023095-4dannjjm 5744 10 some some DT cord-023095-4dannjjm 5744 11 submitted submit VBN cord-023095-4dannjjm 5744 12 in in IN cord-023095-4dannjjm 5744 13 formalin formalin NN cord-023095-4dannjjm 5744 14 consisted consisted NNS cord-023095-4dannjjm 5744 15 of of IN cord-023095-4dannjjm 5744 16 newberyite newberyite NNP cord-023095-4dannjjm 5744 17 ( ( -LRB- cord-023095-4dannjjm 5744 18 magnesium magnesium NN cord-023095-4dannjjm 5744 19 hydrogen hydrogen NN cord-023095-4dannjjm 5744 20 phosphate phosphate NN cord-023095-4dannjjm 5744 21 trihydrate trihydrate NNP cord-023095-4dannjjm 5744 22 ) ) -RRB- cord-023095-4dannjjm 5744 23 . . . cord-023095-4dannjjm 5745 1 Because because IN cord-023095-4dannjjm 5745 2 newberyite newberyite NNP cord-023095-4dannjjm 5745 3 is be VBZ cord-023095-4dannjjm 5745 4 uncommonly uncommonly RB cord-023095-4dannjjm 5745 5 found find VBN cord-023095-4dannjjm 5745 6 in in IN cord-023095-4dannjjm 5745 7 uroliths urolith NNS cord-023095-4dannjjm 5745 8 formed form VBN cord-023095-4dannjjm 5745 9 by by IN cord-023095-4dannjjm 5745 10 cats cat NNS cord-023095-4dannjjm 5745 11 and and CC cord-023095-4dannjjm 5745 12 dogs dog NNS cord-023095-4dannjjm 5745 13 , , , cord-023095-4dannjjm 5745 14 we -PRON- PRP cord-023095-4dannjjm 5745 15 hypothesized hypothesize VBD cord-023095-4dannjjm 5745 16 that that IN cord-023095-4dannjjm 5745 17 this this DT cord-023095-4dannjjm 5745 18 mineral mineral NN cord-023095-4dannjjm 5745 19 was be VBD cord-023095-4dannjjm 5745 20 an an DT cord-023095-4dannjjm 5745 21 in in IN cord-023095-4dannjjm 5745 22 vitro vitro FW cord-023095-4dannjjm 5745 23 artifact artifact NN cord-023095-4dannjjm 5745 24 caused cause VBN cord-023095-4dannjjm 5745 25 by by IN cord-023095-4dannjjm 5745 26 exposure exposure NN cord-023095-4dannjjm 5745 27 of of IN cord-023095-4dannjjm 5745 28 struvite struvite NN cord-023095-4dannjjm 5745 29 ( ( -LRB- cord-023095-4dannjjm 5745 30 magnesium magnesium NN cord-023095-4dannjjm 5745 31 ammonium ammonium NN cord-023095-4dannjjm 5745 32 phosphate phosphate NN cord-023095-4dannjjm 5745 33 hexahydrate hexahydrate NNP cord-023095-4dannjjm 5745 34 ) ) -RRB- cord-023095-4dannjjm 5745 35 to to IN cord-023095-4dannjjm 5745 36 formalin formalin NN cord-023095-4dannjjm 5745 37 . . . cord-023095-4dannjjm 5746 1 The the DT cord-023095-4dannjjm 5746 2 purpose purpose NN cord-023095-4dannjjm 5746 3 of of IN cord-023095-4dannjjm 5746 4 this this DT cord-023095-4dannjjm 5746 5 study study NN cord-023095-4dannjjm 5746 6 was be VBD cord-023095-4dannjjm 5746 7 to to TO cord-023095-4dannjjm 5746 8 determine determine VB cord-023095-4dannjjm 5746 9 if if IN cord-023095-4dannjjm 5746 10 formalin formalin NN cord-023095-4dannjjm 5746 11 alters alter VBZ cord-023095-4dannjjm 5746 12 the the DT cord-023095-4dannjjm 5746 13 mineral mineral NN cord-023095-4dannjjm 5746 14 composition composition NN cord-023095-4dannjjm 5746 15 of of IN cord-023095-4dannjjm 5746 16 uroliths uroliths NNP cord-023095-4dannjjm 5746 17 . . . cord-023095-4dannjjm 5747 1 Urolith Urolith NNP cord-023095-4dannjjm 5747 2 submissions submission NNS cord-023095-4dannjjm 5747 3 containing contain VBG cord-023095-4dannjjm 5747 4 stones stone NNS cord-023095-4dannjjm 5747 5 of of IN cord-023095-4dannjjm 5747 6 either either DT cord-023095-4dannjjm 5747 7 100 100 CD cord-023095-4dannjjm 5747 8 % % NN cord-023095-4dannjjm 5747 9 struvite struvite NN cord-023095-4dannjjm 5747 10 ( ( -LRB- cord-023095-4dannjjm 5747 11 n n NN cord-023095-4dannjjm 5747 12 5 5 CD cord-023095-4dannjjm 5747 13 5 5 CD cord-023095-4dannjjm 5747 14 dogs dog NNS cord-023095-4dannjjm 5747 15 and and CC cord-023095-4dannjjm 5747 16 5 5 CD cord-023095-4dannjjm 5747 17 cats cat NNS cord-023095-4dannjjm 5747 18 ) ) -RRB- cord-023095-4dannjjm 5747 19 , , , cord-023095-4dannjjm 5747 20 100 100 CD cord-023095-4dannjjm 5747 21 % % NN cord-023095-4dannjjm 5747 22 calcium calcium NN cord-023095-4dannjjm 5747 23 oxalate oxalate NN cord-023095-4dannjjm 5747 24 ( ( -LRB- cord-023095-4dannjjm 5747 25 n n NN cord-023095-4dannjjm 5747 26 5 5 CD cord-023095-4dannjjm 5747 27 5 5 CD cord-023095-4dannjjm 5747 28 dogs dog NNS cord-023095-4dannjjm 5747 29 and and CC cord-023095-4dannjjm 5747 30 5 5 CD cord-023095-4dannjjm 5747 31 cats cat NNS cord-023095-4dannjjm 5747 32 ) ) -RRB- cord-023095-4dannjjm 5747 33 , , , cord-023095-4dannjjm 5747 34 100 100 CD cord-023095-4dannjjm 5747 35 % % NN cord-023095-4dannjjm 5747 36 calcium calcium NN cord-023095-4dannjjm 5747 37 phosphate phosphate NN cord-023095-4dannjjm 5747 38 apatite apatite NN cord-023095-4dannjjm 5747 39 ( ( -LRB- cord-023095-4dannjjm 5747 40 n n NN cord-023095-4dannjjm 5747 41 5 5 CD cord-023095-4dannjjm 5747 42 5 5 CD cord-023095-4dannjjm 5747 43 dogs dog NNS cord-023095-4dannjjm 5747 44 and and CC cord-023095-4dannjjm 5747 45 5 5 CD cord-023095-4dannjjm 5747 46 cats cat NNS cord-023095-4dannjjm 5747 47 ) ) -RRB- cord-023095-4dannjjm 5747 48 , , , cord-023095-4dannjjm 5747 49 100 100 CD cord-023095-4dannjjm 5747 50 % % NN cord-023095-4dannjjm 5747 51 cystine cystine NN cord-023095-4dannjjm 5747 52 ( ( -LRB- cord-023095-4dannjjm 5747 53 n n NN cord-023095-4dannjjm 5747 54 5 5 CD cord-023095-4dannjjm 5747 55 5 5 CD cord-023095-4dannjjm 5747 56 dogs dog NNS cord-023095-4dannjjm 5747 57 and and CC cord-023095-4dannjjm 5747 58 5 5 CD cord-023095-4dannjjm 5747 59 cats cat NNS cord-023095-4dannjjm 5747 60 ) ) -RRB- cord-023095-4dannjjm 5747 61 , , , cord-023095-4dannjjm 5747 62 100 100 CD cord-023095-4dannjjm 5747 63 % % NN cord-023095-4dannjjm 5747 64 ammonium ammonium NN cord-023095-4dannjjm 5747 65 urate urate NN cord-023095-4dannjjm 5747 66 ( ( -LRB- cord-023095-4dannjjm 5747 67 n n NN cord-023095-4dannjjm 5747 68 5 5 CD cord-023095-4dannjjm 5747 69 5 5 CD cord-023095-4dannjjm 5747 70 dogs dog NNS cord-023095-4dannjjm 5747 71 and and CC cord-023095-4dannjjm 5747 72 5 5 CD cord-023095-4dannjjm 5747 73 cats cat NNS cord-023095-4dannjjm 5747 74 ) ) -RRB- cord-023095-4dannjjm 5747 75 , , , cord-023095-4dannjjm 5747 76 and and CC cord-023095-4dannjjm 5747 77 100 100 CD cord-023095-4dannjjm 5747 78 % % NN cord-023095-4dannjjm 5747 79 silica silica NN cord-023095-4dannjjm 5747 80 ( ( -LRB- cord-023095-4dannjjm 5747 81 n n NN cord-023095-4dannjjm 5747 82 5 5 CD cord-023095-4dannjjm 5747 83 5 5 CD cord-023095-4dannjjm 5747 84 dogs dog NNS cord-023095-4dannjjm 5747 85 ) ) -RRB- cord-023095-4dannjjm 5747 86 preserved preserve VBN cord-023095-4dannjjm 5747 87 by by IN cord-023095-4dannjjm 5747 88 only only JJ cord-023095-4dannjjm 5747 89 air air NN cord-023095-4dannjjm 5747 90 drying drying NN cord-023095-4dannjjm 5747 91 were be VBD cord-023095-4dannjjm 5747 92 tested test VBN cord-023095-4dannjjm 5747 93 . . . cord-023095-4dannjjm 5748 1 One one CD cord-023095-4dannjjm 5748 2 urolith urolith NN cord-023095-4dannjjm 5748 3 from from IN cord-023095-4dannjjm 5748 4 each each DT cord-023095-4dannjjm 5748 5 submission submission NN cord-023095-4dannjjm 5748 6 was be VBD cord-023095-4dannjjm 5748 7 quantitatively quantitatively RB cord-023095-4dannjjm 5748 8 analyzed analyze VBN cord-023095-4dannjjm 5748 9 by by IN cord-023095-4dannjjm 5748 10 polarized polarized JJ cord-023095-4dannjjm 5748 11 light light JJ cord-023095-4dannjjm 5748 12 microscopy microscopy NNS cord-023095-4dannjjm 5748 13 or or CC cord-023095-4dannjjm 5748 14 infrared infrared JJ cord-023095-4dannjjm 5748 15 spectroscopy spectroscopy NN cord-023095-4dannjjm 5748 16 . . . cord-023095-4dannjjm 5749 1 A a DT cord-023095-4dannjjm 5749 2 subsequent subsequent JJ cord-023095-4dannjjm 5749 3 urolith urolith NN cord-023095-4dannjjm 5749 4 from from IN cord-023095-4dannjjm 5749 5 the the DT cord-023095-4dannjjm 5749 6 same same JJ cord-023095-4dannjjm 5749 7 submission submission NN cord-023095-4dannjjm 5749 8 was be VBD cord-023095-4dannjjm 5749 9 immersed immerse VBN cord-023095-4dannjjm 5749 10 in in IN cord-023095-4dannjjm 5749 11 1 1 CD cord-023095-4dannjjm 5749 12 ml ml NNS cord-023095-4dannjjm 5749 13 of of IN cord-023095-4dannjjm 5749 14 10 10 CD cord-023095-4dannjjm 5749 15 % % NN cord-023095-4dannjjm 5749 16 buffered buffer VBN cord-023095-4dannjjm 5749 17 formalin formalin NN cord-023095-4dannjjm 5749 18 for for IN cord-023095-4dannjjm 5749 19 48 48 CD cord-023095-4dannjjm 5749 20 hours hour NNS cord-023095-4dannjjm 5749 21 at at IN cord-023095-4dannjjm 5749 22 room room NN cord-023095-4dannjjm 5749 23 temperature temperature NN cord-023095-4dannjjm 5749 24 . . . cord-023095-4dannjjm 5750 1 Uroliths Uroliths NNP cord-023095-4dannjjm 5750 2 were be VBD cord-023095-4dannjjm 5750 3 then then RB cord-023095-4dannjjm 5750 4 air air NN cord-023095-4dannjjm 5750 5 dried dry VBN cord-023095-4dannjjm 5750 6 for for IN cord-023095-4dannjjm 5750 7 30 30 CD cord-023095-4dannjjm 5750 8 minutes minute NNS cord-023095-4dannjjm 5750 9 and and CC cord-023095-4dannjjm 5750 10 the the DT cord-023095-4dannjjm 5750 11 analysis analysis NN cord-023095-4dannjjm 5750 12 was be VBD cord-023095-4dannjjm 5750 13 repeated repeat VBN cord-023095-4dannjjm 5750 14 . . . cord-023095-4dannjjm 5751 1 After after IN cord-023095-4dannjjm 5751 2 exposure exposure NN cord-023095-4dannjjm 5751 3 to to IN cord-023095-4dannjjm 5751 4 formalin formalin NN cord-023095-4dannjjm 5751 5 , , , cord-023095-4dannjjm 5751 6 portions portion NNS cord-023095-4dannjjm 5751 7 of of IN cord-023095-4dannjjm 5751 8 all all DT cord-023095-4dannjjm 5751 9 10 10 CD cord-023095-4dannjjm 5751 10 struvite struvite NN cord-023095-4dannjjm 5751 11 uroliths urolith NNS cord-023095-4dannjjm 5751 12 were be VBD cord-023095-4dannjjm 5751 13 transformed transform VBN cord-023095-4dannjjm 5751 14 into into IN cord-023095-4dannjjm 5751 15 newberyite newberyite NNP cord-023095-4dannjjm 5751 16 . . . cord-023095-4dannjjm 5752 1 Three three CD cord-023095-4dannjjm 5752 2 ( ( -LRB- cord-023095-4dannjjm 5752 3 1 1 CD cord-023095-4dannjjm 5752 4 dog dog NN cord-023095-4dannjjm 5752 5 and and CC cord-023095-4dannjjm 5752 6 2 2 CD cord-023095-4dannjjm 5752 7 cats cat NNS cord-023095-4dannjjm 5752 8 ) ) -RRB- cord-023095-4dannjjm 5752 9 of of IN cord-023095-4dannjjm 5752 10 10 10 CD cord-023095-4dannjjm 5752 11 ammonium ammonium NN cord-023095-4dannjjm 5752 12 urate urate NN cord-023095-4dannjjm 5752 13 uroliths urolith NNS cord-023095-4dannjjm 5752 14 were be VBD cord-023095-4dannjjm 5752 15 completely completely RB cord-023095-4dannjjm 5752 16 dissolved dissolve VBN cord-023095-4dannjjm 5752 17 . . . cord-023095-4dannjjm 5753 1 Newberyite Newberyite NNP cord-023095-4dannjjm 5753 2 was be VBD cord-023095-4dannjjm 5753 3 not not RB cord-023095-4dannjjm 5753 4 detected detect VBN cord-023095-4dannjjm 5753 5 in in IN cord-023095-4dannjjm 5753 6 any any DT cord-023095-4dannjjm 5753 7 of of IN cord-023095-4dannjjm 5753 8 the the DT cord-023095-4dannjjm 5753 9 remaining remain VBG cord-023095-4dannjjm 5753 10 uroliths urolith NNS cord-023095-4dannjjm 5753 11 . . . cord-023095-4dannjjm 5754 1 Likewise likewise RB cord-023095-4dannjjm 5754 2 quantitative quantitative JJ cord-023095-4dannjjm 5754 3 mineral mineral NN cord-023095-4dannjjm 5754 4 analysis analysis NN cord-023095-4dannjjm 5754 5 of of IN cord-023095-4dannjjm 5754 6 non non JJ cord-023095-4dannjjm 5754 7 - - JJ cord-023095-4dannjjm 5754 8 struvite struvite JJ cord-023095-4dannjjm 5754 9 uroliths urolith NNS cord-023095-4dannjjm 5754 10 remained remain VBD cord-023095-4dannjjm 5754 11 unchanged unchanged JJ cord-023095-4dannjjm 5754 12 . . . cord-023095-4dannjjm 5755 1 To to TO cord-023095-4dannjjm 5755 2 avoid avoid VB cord-023095-4dannjjm 5755 3 misdiagnosis misdiagnosis NN cord-023095-4dannjjm 5755 4 of of IN cord-023095-4dannjjm 5755 5 mineral mineral NN cord-023095-4dannjjm 5755 6 composition composition NN cord-023095-4dannjjm 5755 7 , , , cord-023095-4dannjjm 5755 8 uroliths uroliths NNP cord-023095-4dannjjm 5755 9 should should MD cord-023095-4dannjjm 5755 10 not not RB cord-023095-4dannjjm 5755 11 be be VB cord-023095-4dannjjm 5755 12 immersed immerse VBN cord-023095-4dannjjm 5755 13 in in IN cord-023095-4dannjjm 5755 14 formalin formalin NN cord-023095-4dannjjm 5755 15 prior prior RB cord-023095-4dannjjm 5755 16 to to IN cord-023095-4dannjjm 5755 17 analysis analysis NN cord-023095-4dannjjm 5755 18 . . . cord-023095-4dannjjm 5756 1 We -PRON- PRP cord-023095-4dannjjm 5756 2 previously previously RB cord-023095-4dannjjm 5756 3 reported report VBD cord-023095-4dannjjm 5756 4 that that IN cord-023095-4dannjjm 5756 5 transfusion transfusion NN cord-023095-4dannjjm 5756 6 to to IN cord-023095-4dannjjm 5756 7 normal normal JJ cord-023095-4dannjjm 5756 8 dogs dog NNS cord-023095-4dannjjm 5756 9 of of IN cord-023095-4dannjjm 5756 10 autologous autologous JJ cord-023095-4dannjjm 5756 11 erythrocyte erythrocyte NN cord-023095-4dannjjm 5756 12 concentrates concentrate VBZ cord-023095-4dannjjm 5756 13 ( ( -LRB- cord-023095-4dannjjm 5756 14 pRBCs prbcs RB cord-023095-4dannjjm 5756 15 ) ) -RRB- cord-023095-4dannjjm 5756 16 that that WDT cord-023095-4dannjjm 5756 17 had have VBD cord-023095-4dannjjm 5756 18 been be VBN cord-023095-4dannjjm 5756 19 stored store VBN cord-023095-4dannjjm 5756 20 for for IN cord-023095-4dannjjm 5756 21 21 21 CD cord-023095-4dannjjm 5756 22 days day NNS cord-023095-4dannjjm 5756 23 causes cause VBZ cord-023095-4dannjjm 5756 24 a a DT cord-023095-4dannjjm 5756 25 profound profound JJ cord-023095-4dannjjm 5756 26 inflammatory inflammatory JJ cord-023095-4dannjjm 5756 27 response response NN cord-023095-4dannjjm 5756 28 ( ( -LRB- cord-023095-4dannjjm 5756 29 2X 2x CD cord-023095-4dannjjm 5756 30 increase increase NN cord-023095-4dannjjm 5756 31 in in IN cord-023095-4dannjjm 5756 32 leucocyte leucocyte NNP cord-023095-4dannjjm 5756 33 count count NN cord-023095-4dannjjm 5756 34 and and CC cord-023095-4dannjjm 5756 35 fibrinogen fibrinogen NN cord-023095-4dannjjm 5756 36 , , , cord-023095-4dannjjm 5756 37 60X 60x JJ cord-023095-4dannjjm 5756 38 increase increase NN cord-023095-4dannjjm 5756 39 in in IN cord-023095-4dannjjm 5756 40 C C NNP cord-023095-4dannjjm 5756 41 - - HYPH cord-023095-4dannjjm 5756 42 Reactive Reactive NNP cord-023095-4dannjjm 5756 43 Protein Protein NNP cord-023095-4dannjjm 5756 44 ) ) -RRB- cord-023095-4dannjjm 5756 45 . . . cord-023095-4dannjjm 5757 1 We -PRON- PRP cord-023095-4dannjjm 5757 2 speculated speculate VBD cord-023095-4dannjjm 5757 3 that that IN cord-023095-4dannjjm 5757 4 inflammation inflammation NN cord-023095-4dannjjm 5757 5 was be VBD cord-023095-4dannjjm 5757 6 due due JJ cord-023095-4dannjjm 5757 7 to to IN cord-023095-4dannjjm 5757 8 cytokines cytokine NNS cord-023095-4dannjjm 5757 9 produced produce VBN cord-023095-4dannjjm 5757 10 during during IN cord-023095-4dannjjm 5757 11 the the DT cord-023095-4dannjjm 5757 12 storage storage NN cord-023095-4dannjjm 5757 13 period period NN cord-023095-4dannjjm 5757 14 , , , cord-023095-4dannjjm 5757 15 and and CC cord-023095-4dannjjm 5757 16 hypothesized hypothesize VBD cord-023095-4dannjjm 5757 17 that that IN cord-023095-4dannjjm 5757 18 transfusion transfusion NN cord-023095-4dannjjm 5757 19 of of IN cord-023095-4dannjjm 5757 20 fresh fresh JJ cord-023095-4dannjjm 5757 21 ( ( -LRB- cord-023095-4dannjjm 5757 22 F f NN cord-023095-4dannjjm 5757 23 ) ) -RRB- cord-023095-4dannjjm 5757 24 pRBCs prbcs RB cord-023095-4dannjjm 5757 25 would would MD cord-023095-4dannjjm 5757 26 elicit elicit VB cord-023095-4dannjjm 5757 27 less less JJR cord-023095-4dannjjm 5757 28 inflammation inflammation NN cord-023095-4dannjjm 5757 29 than than IN cord-023095-4dannjjm 5757 30 would would MD cord-023095-4dannjjm 5757 31 stored store VBN cord-023095-4dannjjm 5757 32 ( ( -LRB- cord-023095-4dannjjm 5757 33 S s NN cord-023095-4dannjjm 5757 34 ) ) -RRB- cord-023095-4dannjjm 5757 35 pRBCs prbcs RB cord-023095-4dannjjm 5757 36 . . . cord-023095-4dannjjm 5758 1 A a DT cord-023095-4dannjjm 5758 2 whole whole JJ cord-023095-4dannjjm 5758 3 blood blood NN cord-023095-4dannjjm 5758 4 unit unit NN cord-023095-4dannjjm 5758 5 was be VBD cord-023095-4dannjjm 5758 6 collected collect VBN cord-023095-4dannjjm 5758 7 from from IN cord-023095-4dannjjm 5758 8 healthy healthy JJ cord-023095-4dannjjm 5758 9 dogs dog NNS cord-023095-4dannjjm 5758 10 ( ( -LRB- cord-023095-4dannjjm 5758 11 n n NN cord-023095-4dannjjm 5758 12 5 5 CD cord-023095-4dannjjm 5758 13 10 10 CD cord-023095-4dannjjm 5758 14 ) ) -RRB- cord-023095-4dannjjm 5758 15 for for IN cord-023095-4dannjjm 5758 16 pRBCs pRBCs NNP cord-023095-4dannjjm 5758 17 on on IN cord-023095-4dannjjm 5758 18 day day NN cord-023095-4dannjjm 5758 19 0 0 CD cord-023095-4dannjjm 5758 20 , , , cord-023095-4dannjjm 5758 21 then then RB cord-023095-4dannjjm 5758 22 again again RB cord-023095-4dannjjm 5758 23 on on IN cord-023095-4dannjjm 5758 24 day day NN cord-023095-4dannjjm 5758 25 32 32 CD cord-023095-4dannjjm 5758 26 . . . cord-023095-4dannjjm 5759 1 On on IN cord-023095-4dannjjm 5759 2 day day NN cord-023095-4dannjjm 5759 3 35 35 CD cord-023095-4dannjjm 5759 4 dogs dog NNS cord-023095-4dannjjm 5759 5 received receive VBD cord-023095-4dannjjm 5759 6 an an DT cord-023095-4dannjjm 5759 7 autologous autologous JJ cord-023095-4dannjjm 5759 8 transfusion transfusion NN cord-023095-4dannjjm 5759 9 of of IN cord-023095-4dannjjm 5759 10 pRBCs prbcs RB cord-023095-4dannjjm 5759 11 stored store VBN cord-023095-4dannjjm 5759 12 for for IN cord-023095-4dannjjm 5759 13 either either DT cord-023095-4dannjjm 5759 14 35 35 CD cord-023095-4dannjjm 5759 15 days day NNS cord-023095-4dannjjm 5759 16 ( ( -LRB- cord-023095-4dannjjm 5759 17 S S NNP cord-023095-4dannjjm 5759 18 , , , cord-023095-4dannjjm 5759 19 n n NN cord-023095-4dannjjm 5759 20 5 5 CD cord-023095-4dannjjm 5759 21 5 5 CD cord-023095-4dannjjm 5759 22 ) ) -RRB- cord-023095-4dannjjm 5759 23 or or CC cord-023095-4dannjjm 5759 24 3 3 CD cord-023095-4dannjjm 5759 25 days day NNS cord-023095-4dannjjm 5759 26 ( ( -LRB- cord-023095-4dannjjm 5759 27 F F NNP cord-023095-4dannjjm 5759 28 , , , cord-023095-4dannjjm 5759 29 n n NN cord-023095-4dannjjm 5759 30 5 5 CD cord-023095-4dannjjm 5759 31 5 5 CD cord-023095-4dannjjm 5759 32 ) ) -RRB- cord-023095-4dannjjm 5759 33 . . . cord-023095-4dannjjm 5760 1 CBCs CBCs NNP cord-023095-4dannjjm 5760 2 and and CC cord-023095-4dannjjm 5760 3 in in IN cord-023095-4dannjjm 5760 4 - - HYPH cord-023095-4dannjjm 5760 5 tem tem NN cord-023095-4dannjjm 5760 6 thromboelastometry thromboelastometry NN cord-023095-4dannjjm 5760 7 ( ( -LRB- cord-023095-4dannjjm 5760 8 CT CT NNP cord-023095-4dannjjm 5760 9 : : : cord-023095-4dannjjm 5760 10 coagulation coagulation NN cord-023095-4dannjjm 5760 11 time time NN cord-023095-4dannjjm 5760 12 , , , cord-023095-4dannjjm 5760 13 CFT CFT NNP cord-023095-4dannjjm 5760 14 : : : cord-023095-4dannjjm 5760 15 clot clot NN cord-023095-4dannjjm 5760 16 formation formation NN cord-023095-4dannjjm 5760 17 time time NN cord-023095-4dannjjm 5760 18 , , , cord-023095-4dannjjm 5760 19 a a DT cord-023095-4dannjjm 5760 20 : : : cord-023095-4dannjjm 5760 21 alpha alpha NN cord-023095-4dannjjm 5760 22 , , , cord-023095-4dannjjm 5760 23 MCF MCF NNP cord-023095-4dannjjm 5760 24 : : : cord-023095-4dannjjm 5760 25 maximum maximum JJ cord-023095-4dannjjm 5760 26 clot clot NN cord-023095-4dannjjm 5760 27 firmness firmness NN cord-023095-4dannjjm 5760 28 ) ) -RRB- cord-023095-4dannjjm 5760 29 were be VBD cord-023095-4dannjjm 5760 30 evaluated evaluate VBN cord-023095-4dannjjm 5760 31 on on IN cord-023095-4dannjjm 5760 32 blood blood NN cord-023095-4dannjjm 5760 33 samples sample NNS cord-023095-4dannjjm 5760 34 collected collect VBN cord-023095-4dannjjm 5760 35 at at IN cord-023095-4dannjjm 5760 36 0 0 CD cord-023095-4dannjjm 5760 37 ( ( -LRB- cord-023095-4dannjjm 5760 38 pre pre JJ cord-023095-4dannjjm 5760 39 ) ) -RRB- cord-023095-4dannjjm 5760 40 and and CC cord-023095-4dannjjm 5760 41 5,9,24,48 5,9,24,48 CD cord-023095-4dannjjm 5760 42 , , , cord-023095-4dannjjm 5760 43 and and CC cord-023095-4dannjjm 5760 44 72 72 CD cord-023095-4dannjjm 5760 45 hours hour NNS cord-023095-4dannjjm 5760 46 after after IN cord-023095-4dannjjm 5760 47 transfusion transfusion NN cord-023095-4dannjjm 5760 48 . . . cord-023095-4dannjjm 5761 1 Fresh fresh JJ cord-023095-4dannjjm 5761 2 pRBCs prbc NNS cord-023095-4dannjjm 5761 3 did do VBD cord-023095-4dannjjm 5761 4 not not RB cord-023095-4dannjjm 5761 5 elicit elicit VB cord-023095-4dannjjm 5761 6 any any DT cord-023095-4dannjjm 5761 7 change change NN cord-023095-4dannjjm 5761 8 in in IN cord-023095-4dannjjm 5761 9 leucocytes leucocyte NNS cord-023095-4dannjjm 5761 10 , , , cord-023095-4dannjjm 5761 11 platelets platelet NNS cord-023095-4dannjjm 5761 12 , , , cord-023095-4dannjjm 5761 13 or or CC cord-023095-4dannjjm 5761 14 thromboelastometry thromboelastometry NN cord-023095-4dannjjm 5761 15 . . . cord-023095-4dannjjm 5762 1 Stored store VBN cord-023095-4dannjjm 5762 2 pRBCs prbcs RB cord-023095-4dannjjm 5762 3 elicited elicit VBD cord-023095-4dannjjm 5762 4 a a DT cord-023095-4dannjjm 5762 5 degenerative degenerative JJ cord-023095-4dannjjm 5762 6 left left JJ cord-023095-4dannjjm 5762 7 shift shift NN cord-023095-4dannjjm 5762 8 ( ( -LRB- cord-023095-4dannjjm 5762 9 5 5 CD cord-023095-4dannjjm 5762 10 hr hr NN cord-023095-4dannjjm 5762 11 ) ) -RRB- cord-023095-4dannjjm 5762 12 followed follow VBN cord-023095-4dannjjm 5762 13 by by IN cord-023095-4dannjjm 5762 14 a a DT cord-023095-4dannjjm 5762 15 regenerative regenerative JJ cord-023095-4dannjjm 5762 16 left left JJ cord-023095-4dannjjm 5762 17 shift shift NN cord-023095-4dannjjm 5762 18 ( ( -LRB- cord-023095-4dannjjm 5762 19 9 9 CD cord-023095-4dannjjm 5762 20 - - SYM cord-023095-4dannjjm 5762 21 48 48 CD cord-023095-4dannjjm 5762 22 hr hr NN cord-023095-4dannjjm 5762 23 ) ) -RRB- cord-023095-4dannjjm 5762 24 , , , cord-023095-4dannjjm 5762 25 thrombocytopenia thrombocytopenia NN cord-023095-4dannjjm 5762 26 ( ( -LRB- cord-023095-4dannjjm 5762 27 36 36 CD cord-023095-4dannjjm 5762 28 % % NN cord-023095-4dannjjm 5762 29 decrease decrease NN cord-023095-4dannjjm 5762 30 at at IN cord-023095-4dannjjm 5762 31 5 5 CD cord-023095-4dannjjm 5762 32 hr hr NN cord-023095-4dannjjm 5762 33 ) ) -RRB- cord-023095-4dannjjm 5762 34 , , , cord-023095-4dannjjm 5762 35 and and CC cord-023095-4dannjjm 5762 36 marked mark VBD cord-023095-4dannjjm 5762 37 hypocoagulability hypocoagulability NN cord-023095-4dannjjm 5762 38 characterized characterize VBN cord-023095-4dannjjm 5762 39 by by IN cord-023095-4dannjjm 5762 40 prolonged prolong VBN cord-023095-4dannjjm 5762 41 CT CT NNP cord-023095-4dannjjm 5762 42 ( ( -LRB- cord-023095-4dannjjm 5762 43 5,9,24 5,9,24 CD cord-023095-4dannjjm 5762 44 hr hr NN cord-023095-4dannjjm 5762 45 ) ) -RRB- cord-023095-4dannjjm 5762 46 and and CC cord-023095-4dannjjm 5762 47 CFT CFT NNP cord-023095-4dannjjm 5762 48 ( ( -LRB- cord-023095-4dannjjm 5762 49 5,9 5,9 CD cord-023095-4dannjjm 5762 50 hr hr NN cord-023095-4dannjjm 5762 51 ) ) -RRB- cord-023095-4dannjjm 5762 52 , , , cord-023095-4dannjjm 5762 53 and and CC cord-023095-4dannjjm 5762 54 decreased decrease VBD cord-023095-4dannjjm 5762 55 a a DT cord-023095-4dannjjm 5762 56 ( ( -LRB- cord-023095-4dannjjm 5762 57 5,9 5,9 CD cord-023095-4dannjjm 5762 58 hr hr NN cord-023095-4dannjjm 5762 59 ) ) -RRB- cord-023095-4dannjjm 5762 60 and and CC cord-023095-4dannjjm 5762 61 MCF MCF NNP cord-023095-4dannjjm 5762 62 ( ( -LRB- cord-023095-4dannjjm 5762 63 5,9 5,9 CD cord-023095-4dannjjm 5762 64 , , , cord-023095-4dannjjm 5762 65 24 24 CD cord-023095-4dannjjm 5762 66 hr hr NN cord-023095-4dannjjm 5762 67 ) ) -RRB- cord-023095-4dannjjm 5762 68 . . . cord-023095-4dannjjm 5763 1 Data datum NNS cord-023095-4dannjjm 5763 2 are be VBP cord-023095-4dannjjm 5763 3 mean(SD mean(sd NN cord-023095-4dannjjm 5763 4 ) ) -RRB- cord-023095-4dannjjm 5763 5 . . . cord-023095-4dannjjm 5764 1 a a LS cord-023095-4dannjjm 5764 2 : : : cord-023095-4dannjjm 5764 3 p p NN cord-023095-4dannjjm 5764 4 o o NN cord-023095-4dannjjm 5764 5 0.05 0.05 CD cord-023095-4dannjjm 5764 6 between between IN cord-023095-4dannjjm 5764 7 groups group NNS cord-023095-4dannjjm 5764 8 F F NNP cord-023095-4dannjjm 5764 9 and and CC cord-023095-4dannjjm 5764 10 S S NNP cord-023095-4dannjjm 5764 11 by by IN cord-023095-4dannjjm 5764 12 t t NNP cord-023095-4dannjjm 5764 13 test test NN cord-023095-4dannjjm 5764 14 . . . cord-023095-4dannjjm 5765 1 b b LS cord-023095-4dannjjm 5765 2 : : : cord-023095-4dannjjm 5765 3 p p NN cord-023095-4dannjjm 5765 4 o o NN cord-023095-4dannjjm 5765 5 0.05 0.05 CD cord-023095-4dannjjm 5765 6 compared compare VBN cord-023095-4dannjjm 5765 7 to to IN cord-023095-4dannjjm 5765 8 ' ' '' cord-023095-4dannjjm 5765 9 ' ' `` cord-023095-4dannjjm 5765 10 0 0 CD cord-023095-4dannjjm 5765 11 ' ' '' cord-023095-4dannjjm 5765 12 ' ' '' cord-023095-4dannjjm 5765 13 by by IN cord-023095-4dannjjm 5765 14 RM RM NNP cord-023095-4dannjjm 5765 15 ANOVA ANOVA NNP cord-023095-4dannjjm 5765 16 . . . cord-023095-4dannjjm 5766 1 Transfusion transfusion NN cord-023095-4dannjjm 5766 2 of of IN cord-023095-4dannjjm 5766 3 autologous autologous JJ cord-023095-4dannjjm 5766 4 stored store VBN cord-023095-4dannjjm 5766 5 pRBCs pRBCs NNPS cord-023095-4dannjjm 5766 6 elicits elicit VBZ cord-023095-4dannjjm 5766 7 a a DT cord-023095-4dannjjm 5766 8 greater great JJR cord-023095-4dannjjm 5766 9 inflammatory inflammatory JJ cord-023095-4dannjjm 5766 10 response response NN cord-023095-4dannjjm 5766 11 than than IN cord-023095-4dannjjm 5766 12 fresh fresh JJ cord-023095-4dannjjm 5766 13 pRBCs prbc NNS cord-023095-4dannjjm 5766 14 , , , cord-023095-4dannjjm 5766 15 and and CC cord-023095-4dannjjm 5766 16 results result NNS cord-023095-4dannjjm 5766 17 in in IN cord-023095-4dannjjm 5766 18 hypocoagulability hypocoagulability NN cord-023095-4dannjjm 5766 19 on on IN cord-023095-4dannjjm 5766 20 thromboelastometry thromboelastometry NNP cord-023095-4dannjjm 5766 21 . . . cord-023095-4dannjjm 5767 1 Clopidogrel Clopidogrel NNP cord-023095-4dannjjm 5767 2 is be VBZ cord-023095-4dannjjm 5767 3 a a DT cord-023095-4dannjjm 5767 4 potent potent JJ cord-023095-4dannjjm 5767 5 antiplatelet antiplatelet NN cord-023095-4dannjjm 5767 6 drug drug NN cord-023095-4dannjjm 5767 7 that that WDT cord-023095-4dannjjm 5767 8 is be VBZ cord-023095-4dannjjm 5767 9 gaining gain VBG cord-023095-4dannjjm 5767 10 popularity popularity NN cord-023095-4dannjjm 5767 11 in in IN cord-023095-4dannjjm 5767 12 veterinary veterinary JJ cord-023095-4dannjjm 5767 13 medicine medicine NN cord-023095-4dannjjm 5767 14 for for IN cord-023095-4dannjjm 5767 15 antithrombotic antithrombotic JJ cord-023095-4dannjjm 5767 16 therapy therapy NN cord-023095-4dannjjm 5767 17 . . . cord-023095-4dannjjm 5768 1 The the DT cord-023095-4dannjjm 5768 2 parent parent NN cord-023095-4dannjjm 5768 3 molecule molecule NN cord-023095-4dannjjm 5768 4 is be VBZ cord-023095-4dannjjm 5768 5 an an DT cord-023095-4dannjjm 5768 6 inactive inactive JJ cord-023095-4dannjjm 5768 7 prodrug prodrug NN cord-023095-4dannjjm 5768 8 that that WDT cord-023095-4dannjjm 5768 9 must must MD cord-023095-4dannjjm 5768 10 be be VB cord-023095-4dannjjm 5768 11 converted convert VBN cord-023095-4dannjjm 5768 12 by by IN cord-023095-4dannjjm 5768 13 hepatic hepatic JJ cord-023095-4dannjjm 5768 14 isozymes isozyme NNS cord-023095-4dannjjm 5768 15 to to IN cord-023095-4dannjjm 5768 16 an an DT cord-023095-4dannjjm 5768 17 active active JJ cord-023095-4dannjjm 5768 18 metabolite metabolite NN cord-023095-4dannjjm 5768 19 . . . cord-023095-4dannjjm 5769 1 The the DT cord-023095-4dannjjm 5769 2 majority majority NN cord-023095-4dannjjm 5769 3 of of IN cord-023095-4dannjjm 5769 4 the the DT cord-023095-4dannjjm 5769 5 parent parent NN cord-023095-4dannjjm 5769 6 molecule molecule NN cord-023095-4dannjjm 5769 7 is be VBZ cord-023095-4dannjjm 5769 8 directed direct VBN cord-023095-4dannjjm 5769 9 to to IN cord-023095-4dannjjm 5769 10 the the DT cord-023095-4dannjjm 5769 11 formation formation NN cord-023095-4dannjjm 5769 12 of of IN cord-023095-4dannjjm 5769 13 inactive inactive JJ cord-023095-4dannjjm 5769 14 metabolites metabolite NNS cord-023095-4dannjjm 5769 15 with with IN cord-023095-4dannjjm 5769 16 only only RB cord-023095-4dannjjm 5769 17 an an DT cord-023095-4dannjjm 5769 18 extremely extremely RB cord-023095-4dannjjm 5769 19 small small JJ cord-023095-4dannjjm 5769 20 proportion proportion NN cord-023095-4dannjjm 5769 21 of of IN cord-023095-4dannjjm 5769 22 parent parent NN cord-023095-4dannjjm 5769 23 molecule molecule NN cord-023095-4dannjjm 5769 24 directed direct VBN cord-023095-4dannjjm 5769 25 to to IN cord-023095-4dannjjm 5769 26 the the DT cord-023095-4dannjjm 5769 27 formation formation NN cord-023095-4dannjjm 5769 28 of of IN cord-023095-4dannjjm 5769 29 the the DT cord-023095-4dannjjm 5769 30 active active JJ cord-023095-4dannjjm 5769 31 metabolite metabolite NN cord-023095-4dannjjm 5769 32 . . . cord-023095-4dannjjm 5770 1 There there EX cord-023095-4dannjjm 5770 2 are be VBP cord-023095-4dannjjm 5770 3 multiple multiple JJ cord-023095-4dannjjm 5770 4 hepatic hepatic JJ cord-023095-4dannjjm 5770 5 isozymes isozyme NNS cord-023095-4dannjjm 5770 6 responsible responsible JJ cord-023095-4dannjjm 5770 7 for for IN cord-023095-4dannjjm 5770 8 the the DT cord-023095-4dannjjm 5770 9 formation formation NN cord-023095-4dannjjm 5770 10 of of IN cord-023095-4dannjjm 5770 11 the the DT cord-023095-4dannjjm 5770 12 active active JJ cord-023095-4dannjjm 5770 13 metabolite metabolite NN cord-023095-4dannjjm 5770 14 . . . cord-023095-4dannjjm 5771 1 A a DT cord-023095-4dannjjm 5771 2 non non JJ cord-023095-4dannjjm 5771 3 - - JJ cord-023095-4dannjjm 5771 4 specific specific JJ cord-023095-4dannjjm 5771 5 hepatic hepatic JJ cord-023095-4dannjjm 5771 6 isozyme isozyme NNS cord-023095-4dannjjm 5771 7 inducer inducer NN cord-023095-4dannjjm 5771 8 such such JJ cord-023095-4dannjjm 5771 9 as as IN cord-023095-4dannjjm 5771 10 rifampin rifampin NNP cord-023095-4dannjjm 5771 11 could could MD cord-023095-4dannjjm 5771 12 increase increase VB cord-023095-4dannjjm 5771 13 the the DT cord-023095-4dannjjm 5771 14 formation formation NN cord-023095-4dannjjm 5771 15 of of IN cord-023095-4dannjjm 5771 16 the the DT cord-023095-4dannjjm 5771 17 active active JJ cord-023095-4dannjjm 5771 18 metabolite metabolite NN cord-023095-4dannjjm 5771 19 of of IN cord-023095-4dannjjm 5771 20 clopidogrel clopidogrel NNP cord-023095-4dannjjm 5771 21 thereby thereby RB cord-023095-4dannjjm 5771 22 increasing increase VBG cord-023095-4dannjjm 5771 23 the the DT cord-023095-4dannjjm 5771 24 pharmacodynamic pharmacodynamic JJ cord-023095-4dannjjm 5771 25 response response NN cord-023095-4dannjjm 5771 26 which which WDT cord-023095-4dannjjm 5771 27 may may MD cord-023095-4dannjjm 5771 28 allow allow VB cord-023095-4dannjjm 5771 29 a a DT cord-023095-4dannjjm 5771 30 reduced reduce VBN cord-023095-4dannjjm 5771 31 drug drug NN cord-023095-4dannjjm 5771 32 dose dose NN cord-023095-4dannjjm 5771 33 to to TO cord-023095-4dannjjm 5771 34 achieve achieve VB cord-023095-4dannjjm 5771 35 a a DT cord-023095-4dannjjm 5771 36 clinical clinical JJ cord-023095-4dannjjm 5771 37 effect effect NN cord-023095-4dannjjm 5771 38 . . . cord-023095-4dannjjm 5772 1 We -PRON- PRP cord-023095-4dannjjm 5772 2 have have VBP cord-023095-4dannjjm 5772 3 previously previously RB cord-023095-4dannjjm 5772 4 presented present VBN cord-023095-4dannjjm 5772 5 data datum NNS cord-023095-4dannjjm 5772 6 supporting support VBG cord-023095-4dannjjm 5772 7 the the DT cord-023095-4dannjjm 5772 8 increased increase VBN cord-023095-4dannjjm 5772 9 pharmacodynamic pharmacodynamic JJ cord-023095-4dannjjm 5772 10 response response NN cord-023095-4dannjjm 5772 11 of of IN cord-023095-4dannjjm 5772 12 clopdiogrel clopdiogrel NNP cord-023095-4dannjjm 5772 13 after after IN cord-023095-4dannjjm 5772 14 rifampin rifampin NN cord-023095-4dannjjm 5772 15 therapy therapy NN cord-023095-4dannjjm 5772 16 . . . cord-023095-4dannjjm 5773 1 The the DT cord-023095-4dannjjm 5773 2 goal goal NN cord-023095-4dannjjm 5773 3 of of IN cord-023095-4dannjjm 5773 4 this this DT cord-023095-4dannjjm 5773 5 study study NN cord-023095-4dannjjm 5773 6 was be VBD cord-023095-4dannjjm 5773 7 to to TO cord-023095-4dannjjm 5773 8 demonstrate demonstrate VB cord-023095-4dannjjm 5773 9 an an DT cord-023095-4dannjjm 5773 10 increased increase VBN cord-023095-4dannjjm 5773 11 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 5773 12 response response NN cord-023095-4dannjjm 5773 13 of of IN cord-023095-4dannjjm 5773 14 clopidogrel clopidogrel NN cord-023095-4dannjjm 5773 15 after after IN cord-023095-4dannjjm 5773 16 rifampin rifampin NNP cord-023095-4dannjjm 5773 17 induction induction NN cord-023095-4dannjjm 5773 18 of of IN cord-023095-4dannjjm 5773 19 hepatic hepatic JJ cord-023095-4dannjjm 5773 20 isozymes isozyme NNS cord-023095-4dannjjm 5773 21 . . . cord-023095-4dannjjm 5774 1 Six six CD cord-023095-4dannjjm 5774 2 healthy healthy JJ cord-023095-4dannjjm 5774 3 , , , cord-023095-4dannjjm 5774 4 purpose purpose NN cord-023095-4dannjjm 5774 5 - - HYPH cord-023095-4dannjjm 5774 6 bred breed VBN cord-023095-4dannjjm 5774 7 dogs dog NNS cord-023095-4dannjjm 5774 8 were be VBD cord-023095-4dannjjm 5774 9 used use VBN cord-023095-4dannjjm 5774 10 for for IN cord-023095-4dannjjm 5774 11 this this DT cord-023095-4dannjjm 5774 12 study study NN cord-023095-4dannjjm 5774 13 . . . cord-023095-4dannjjm 5775 1 The the DT cord-023095-4dannjjm 5775 2 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 5775 3 of of IN cord-023095-4dannjjm 5775 4 clopidogrel clopidogrel NNP cord-023095-4dannjjm 5775 5 were be VBD cord-023095-4dannjjm 5775 6 determined determine VBN cord-023095-4dannjjm 5775 7 by by IN cord-023095-4dannjjm 5775 8 measuring measure VBG cord-023095-4dannjjm 5775 9 the the DT cord-023095-4dannjjm 5775 10 parent parent NN cord-023095-4dannjjm 5775 11 molecule molecule NN cord-023095-4dannjjm 5775 12 , , , cord-023095-4dannjjm 5775 13 primary primary JJ cord-023095-4dannjjm 5775 14 inactive inactive JJ cord-023095-4dannjjm 5775 15 metabolite metabolite JJ cord-023095-4dannjjm 5775 16 and and CC cord-023095-4dannjjm 5775 17 active active JJ cord-023095-4dannjjm 5775 18 metabolite metabolite NN cord-023095-4dannjjm 5775 19 through through IN cord-023095-4dannjjm 5775 20 LC LC NNP cord-023095-4dannjjm 5775 21 / / SYM cord-023095-4dannjjm 5775 22 MS MS NNP cord-023095-4dannjjm 5775 23 / / SYM cord-023095-4dannjjm 5775 24 MS MS NNP cord-023095-4dannjjm 5775 25 . . . cord-023095-4dannjjm 5776 1 The the DT cord-023095-4dannjjm 5776 2 pharmacodynamics pharmacodynamic NNS cord-023095-4dannjjm 5776 3 of of IN cord-023095-4dannjjm 5776 4 clopidogrel clopidogrel NNS cord-023095-4dannjjm 5776 5 were be VBD cord-023095-4dannjjm 5776 6 determined determine VBN cord-023095-4dannjjm 5776 7 by by IN cord-023095-4dannjjm 5776 8 measuring measure VBG cord-023095-4dannjjm 5776 9 collagen collagen NN cord-023095-4dannjjm 5776 10 - - HYPH cord-023095-4dannjjm 5776 11 induced induce VBN cord-023095-4dannjjm 5776 12 whole whole JJ cord-023095-4dannjjm 5776 13 blood blood NN cord-023095-4dannjjm 5776 14 aggregation aggregation NN cord-023095-4dannjjm 5776 15 . . . cord-023095-4dannjjm 5777 1 Blood blood NN cord-023095-4dannjjm 5777 2 samples sample NNS cord-023095-4dannjjm 5777 3 were be VBD cord-023095-4dannjjm 5777 4 collected collect VBN cord-023095-4dannjjm 5777 5 prior prior RB cord-023095-4dannjjm 5777 6 to to IN cord-023095-4dannjjm 5777 7 clopidogrel clopidogrel NNP cord-023095-4dannjjm 5777 8 administration administration NNP cord-023095-4dannjjm 5777 9 ( ( -LRB- cord-023095-4dannjjm 5777 10 baseline baseline NNP cord-023095-4dannjjm 5777 11 ) ) -RRB- cord-023095-4dannjjm 5777 12 , , , cord-023095-4dannjjm 5777 13 after after IN cord-023095-4dannjjm 5777 14 7 7 CD cord-023095-4dannjjm 5777 15 days day NNS cord-023095-4dannjjm 5777 16 of of IN cord-023095-4dannjjm 5777 17 2 2 CD cord-023095-4dannjjm 5777 18 mg mg NNP cord-023095-4dannjjm 5777 19 / / SYM cord-023095-4dannjjm 5777 20 kg kg NNP cord-023095-4dannjjm 5777 21 clopidogrel clopidogrel NNP cord-023095-4dannjjm 5777 22 PO PO NNP cord-023095-4dannjjm 5777 23 q q NNP cord-023095-4dannjjm 5777 24 24 24 CD cord-023095-4dannjjm 5777 25 hrs hrs NN cord-023095-4dannjjm 5777 26 , , , cord-023095-4dannjjm 5777 27 and and CC cord-023095-4dannjjm 5777 28 after after IN cord-023095-4dannjjm 5777 29 7 7 CD cord-023095-4dannjjm 5777 30 days day NNS cord-023095-4dannjjm 5777 31 of of IN cord-023095-4dannjjm 5777 32 2 2 CD cord-023095-4dannjjm 5777 33 mg mg NNP cord-023095-4dannjjm 5777 34 / / SYM cord-023095-4dannjjm 5777 35 kg kg NNP cord-023095-4dannjjm 5777 36 clopidogrel clopidogrel NNP cord-023095-4dannjjm 5777 37 PO PO NNP cord-023095-4dannjjm 5777 38 q q NNP cord-023095-4dannjjm 5777 39 24 24 CD cord-023095-4dannjjm 5777 40 hrs hrs NN cord-023095-4dannjjm 5777 41 1 1 CD cord-023095-4dannjjm 5777 42 10 10 CD cord-023095-4dannjjm 5777 43 mg/ mg/ NN cord-023095-4dannjjm 5777 44 kg kg NNP cord-023095-4dannjjm 5778 1 PO PO NNP cord-023095-4dannjjm 5779 1 q q NNP cord-023095-4dannjjm 5779 2 12 12 CD cord-023095-4dannjjm 5779 3 hrs hrs NN cord-023095-4dannjjm 5779 4 rifampin rifampin NN cord-023095-4dannjjm 5779 5 . . . cord-023095-4dannjjm 5780 1 Given give VBN cord-023095-4dannjjm 5780 2 the the DT cord-023095-4dannjjm 5780 3 absence absence NN cord-023095-4dannjjm 5780 4 of of IN cord-023095-4dannjjm 5780 5 a a DT cord-023095-4dannjjm 5780 6 known know VBN cord-023095-4dannjjm 5780 7 standard standard NN cord-023095-4dannjjm 5780 8 for for IN cord-023095-4dannjjm 5780 9 the the DT cord-023095-4dannjjm 5780 10 active active JJ cord-023095-4dannjjm 5780 11 metabolite metabolite NN cord-023095-4dannjjm 5780 12 , , , cord-023095-4dannjjm 5780 13 only only RB cord-023095-4dannjjm 5780 14 a a DT cord-023095-4dannjjm 5780 15 semi semi JJ cord-023095-4dannjjm 5780 16 - - JJ cord-023095-4dannjjm 5780 17 quantitative quantitative JJ cord-023095-4dannjjm 5780 18 assessment assessment NN cord-023095-4dannjjm 5780 19 of of IN cord-023095-4dannjjm 5780 20 active active JJ cord-023095-4dannjjm 5780 21 metabolite metabolite JJ cord-023095-4dannjjm 5780 22 concentration concentration NN cord-023095-4dannjjm 5780 23 can can MD cord-023095-4dannjjm 5780 24 be be VB cord-023095-4dannjjm 5780 25 made make VBN cord-023095-4dannjjm 5780 26 . . . cord-023095-4dannjjm 5781 1 There there EX cord-023095-4dannjjm 5781 2 was be VBD cord-023095-4dannjjm 5781 3 no no DT cord-023095-4dannjjm 5781 4 identifiable identifiable JJ cord-023095-4dannjjm 5781 5 active active JJ cord-023095-4dannjjm 5781 6 metabolite metabolite JJ cord-023095-4dannjjm 5781 7 peak peak NN cord-023095-4dannjjm 5781 8 noted note VBN cord-023095-4dannjjm 5781 9 at at IN cord-023095-4dannjjm 5781 10 baseline baseline NN cord-023095-4dannjjm 5781 11 or or CC cord-023095-4dannjjm 5781 12 after after IN cord-023095-4dannjjm 5781 13 clopidogrel clopidogrel JJ cord-023095-4dannjjm 5781 14 treatment treatment NN cord-023095-4dannjjm 5781 15 . . . cord-023095-4dannjjm 5782 1 However however RB cord-023095-4dannjjm 5782 2 , , , cord-023095-4dannjjm 5782 3 with with IN cord-023095-4dannjjm 5782 4 clopidogrel clopidogrel NN cord-023095-4dannjjm 5782 5 and and CC cord-023095-4dannjjm 5782 6 rifampin rifampin NN cord-023095-4dannjjm 5782 7 combined combine VBN cord-023095-4dannjjm 5782 8 administration administration NN cord-023095-4dannjjm 5782 9 there there EX cord-023095-4dannjjm 5782 10 was be VBD cord-023095-4dannjjm 5782 11 an an DT cord-023095-4dannjjm 5782 12 active active JJ cord-023095-4dannjjm 5782 13 metabolite metabolite JJ cord-023095-4dannjjm 5782 14 peak peak NN cord-023095-4dannjjm 5782 15 identified identify VBN cord-023095-4dannjjm 5782 16 in in IN cord-023095-4dannjjm 5782 17 all all DT cord-023095-4dannjjm 5782 18 dogs dog NNS cord-023095-4dannjjm 5782 19 with with IN cord-023095-4dannjjm 5782 20 a a DT cord-023095-4dannjjm 5782 21 mean mean JJ cord-023095-4dannjjm 5782 22 area area NN cord-023095-4dannjjm 5782 23 of of IN cord-023095-4dannjjm 5782 24 41.7 41.7 CD cord-023095-4dannjjm 5782 25 AE AE NNP cord-023095-4dannjjm 5782 26 23.5 23.5 CD cord-023095-4dannjjm 5782 27 . . . cord-023095-4dannjjm 5783 1 The the DT cord-023095-4dannjjm 5783 2 development development NN cord-023095-4dannjjm 5783 3 of of IN cord-023095-4dannjjm 5783 4 the the DT cord-023095-4dannjjm 5783 5 active active JJ cord-023095-4dannjjm 5783 6 metabolite metabolite JJ cord-023095-4dannjjm 5783 7 peak peak NN cord-023095-4dannjjm 5783 8 was be VBD cord-023095-4dannjjm 5783 9 associated associate VBN cord-023095-4dannjjm 5783 10 with with IN cord-023095-4dannjjm 5783 11 an an DT cord-023095-4dannjjm 5783 12 increase increase NN cord-023095-4dannjjm 5783 13 in in IN cord-023095-4dannjjm 5783 14 the the DT cord-023095-4dannjjm 5783 15 pharmacodyamic pharmacodyamic JJ cord-023095-4dannjjm 5783 16 response response NN cord-023095-4dannjjm 5783 17 of of IN cord-023095-4dannjjm 5783 18 clopidogrel clopidogrel NN cord-023095-4dannjjm 5783 19 in in IN cord-023095-4dannjjm 5783 20 the the DT cord-023095-4dannjjm 5783 21 dogs dog NNS cord-023095-4dannjjm 5783 22 . . . cord-023095-4dannjjm 5784 1 This this DT cord-023095-4dannjjm 5784 2 is be VBZ cord-023095-4dannjjm 5784 3 the the DT cord-023095-4dannjjm 5784 4 first first JJ cord-023095-4dannjjm 5784 5 study study NN cord-023095-4dannjjm 5784 6 in in IN cord-023095-4dannjjm 5784 7 any any DT cord-023095-4dannjjm 5784 8 species specie NNS cord-023095-4dannjjm 5784 9 to to TO cord-023095-4dannjjm 5784 10 document document VB cord-023095-4dannjjm 5784 11 the the DT cord-023095-4dannjjm 5784 12 increased increase VBN cord-023095-4dannjjm 5784 13 formation formation NN cord-023095-4dannjjm 5784 14 of of IN cord-023095-4dannjjm 5784 15 the the DT cord-023095-4dannjjm 5784 16 active active JJ cord-023095-4dannjjm 5784 17 metabolite metabolite NN cord-023095-4dannjjm 5784 18 of of IN cord-023095-4dannjjm 5784 19 clopidogrel clopidogrel NN cord-023095-4dannjjm 5784 20 in in IN cord-023095-4dannjjm 5784 21 response response NN cord-023095-4dannjjm 5784 22 to to IN cord-023095-4dannjjm 5784 23 a a DT cord-023095-4dannjjm 5784 24 strong strong JJ cord-023095-4dannjjm 5784 25 , , , cord-023095-4dannjjm 5784 26 non non JJ cord-023095-4dannjjm 5784 27 - - JJ cord-023095-4dannjjm 5784 28 specific specific JJ cord-023095-4dannjjm 5784 29 hepatic hepatic JJ cord-023095-4dannjjm 5784 30 isozyme isozyme NNS cord-023095-4dannjjm 5784 31 inducer inducer NN cord-023095-4dannjjm 5784 32 . . . cord-023095-4dannjjm 5785 1 This this DT cord-023095-4dannjjm 5785 2 increased increase VBN cord-023095-4dannjjm 5785 3 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 5785 4 response response NN cord-023095-4dannjjm 5785 5 was be VBD cord-023095-4dannjjm 5785 6 associated associate VBN cord-023095-4dannjjm 5785 7 with with IN cord-023095-4dannjjm 5785 8 an an DT cord-023095-4dannjjm 5785 9 increased increase VBN cord-023095-4dannjjm 5785 10 pharmacodynamic pharmacodynamic JJ cord-023095-4dannjjm 5785 11 response response NN cord-023095-4dannjjm 5785 12 of of IN cord-023095-4dannjjm 5785 13 clopidogrel clopidogrel NN cord-023095-4dannjjm 5785 14 . . . cord-023095-4dannjjm 5786 1 This this DT cord-023095-4dannjjm 5786 2 data data NN cord-023095-4dannjjm 5786 3 provides provide VBZ cord-023095-4dannjjm 5786 4 supportive supportive JJ cord-023095-4dannjjm 5786 5 evidence evidence NN cord-023095-4dannjjm 5786 6 to to TO cord-023095-4dannjjm 5786 7 develop develop VB cord-023095-4dannjjm 5786 8 therapeutic therapeutic JJ cord-023095-4dannjjm 5786 9 protocols protocol NNS cord-023095-4dannjjm 5786 10 to to TO cord-023095-4dannjjm 5786 11 improve improve VB cord-023095-4dannjjm 5786 12 the the DT cord-023095-4dannjjm 5786 13 pharmacodynamic pharmacodynamic JJ cord-023095-4dannjjm 5786 14 response response NN cord-023095-4dannjjm 5786 15 to to IN cord-023095-4dannjjm 5786 16 clopidogrel clopidogrel NN cord-023095-4dannjjm 5786 17 in in IN cord-023095-4dannjjm 5786 18 dogs dog NNS cord-023095-4dannjjm 5786 19 that that WDT cord-023095-4dannjjm 5786 20 may may MD cord-023095-4dannjjm 5786 21 reduce reduce VB cord-023095-4dannjjm 5786 22 dosing dosing NN cord-023095-4dannjjm 5786 23 requirements requirement NNS cord-023095-4dannjjm 5786 24 or or CC cord-023095-4dannjjm 5786 25 correct correct JJ cord-023095-4dannjjm 5786 26 subtherapeutic subtherapeutic JJ cord-023095-4dannjjm 5786 27 pharmacodynamic pharmacodynamic JJ cord-023095-4dannjjm 5786 28 response response NN cord-023095-4dannjjm 5786 29 . . . cord-023095-4dannjjm 5787 1 Critical critical JJ cord-023095-4dannjjm 5787 2 illness illness NN cord-023095-4dannjjm 5787 3 - - HYPH cord-023095-4dannjjm 5787 4 related relate VBN cord-023095-4dannjjm 5787 5 corticosteroid corticosteroid NN cord-023095-4dannjjm 5787 6 insufficiency insufficiency NN cord-023095-4dannjjm 5787 7 ( ( -LRB- cord-023095-4dannjjm 5787 8 CIRCI CIRCI NNP cord-023095-4dannjjm 5787 9 ) ) -RRB- cord-023095-4dannjjm 5787 10 has have VBZ cord-023095-4dannjjm 5787 11 been be VBN cord-023095-4dannjjm 5787 12 identified identify VBN cord-023095-4dannjjm 5787 13 in in IN cord-023095-4dannjjm 5787 14 humans human NNS cord-023095-4dannjjm 5787 15 , , , cord-023095-4dannjjm 5787 16 foals foal NNS cord-023095-4dannjjm 5787 17 , , , cord-023095-4dannjjm 5787 18 dogs dog NNS cord-023095-4dannjjm 5787 19 and and CC cord-023095-4dannjjm 5787 20 cats cat NNS cord-023095-4dannjjm 5787 21 with with IN cord-023095-4dannjjm 5787 22 lower lower RBR cord-023095-4dannjjm 5787 23 - - HYPH cord-023095-4dannjjm 5787 24 thanexpected thanexpecte VBN cord-023095-4dannjjm 5787 25 circulating circulate VBG cord-023095-4dannjjm 5787 26 cortisol cortisol NN cord-023095-4dannjjm 5787 27 concentrations concentration NNS cord-023095-4dannjjm 5787 28 , , , cord-023095-4dannjjm 5787 29 and/or and/or CC cord-023095-4dannjjm 5787 30 by by IN cord-023095-4dannjjm 5787 31 a a DT cord-023095-4dannjjm 5787 32 blunted blunt VBN cord-023095-4dannjjm 5787 33 cortisol cortisol NN cord-023095-4dannjjm 5787 34 response response NN cord-023095-4dannjjm 5787 35 to to IN cord-023095-4dannjjm 5787 36 ACTH ACTH NNP cord-023095-4dannjjm 5787 37 stimulation stimulation NN cord-023095-4dannjjm 5787 38 . . . cord-023095-4dannjjm 5788 1 Our -PRON- PRP$ cord-023095-4dannjjm 5788 2 purpose purpose NN cord-023095-4dannjjm 5788 3 was be VBD cord-023095-4dannjjm 5788 4 to to TO cord-023095-4dannjjm 5788 5 determine determine VB cord-023095-4dannjjm 5788 6 if if IN cord-023095-4dannjjm 5788 7 CIRCI CIRCI NNP cord-023095-4dannjjm 5788 8 exists exist VBZ cord-023095-4dannjjm 5788 9 in in IN cord-023095-4dannjjm 5788 10 critically critically RB cord-023095-4dannjjm 5788 11 ill ill JJ cord-023095-4dannjjm 5788 12 horses horse NNS cord-023095-4dannjjm 5788 13 . . . cord-023095-4dannjjm 5789 1 Endogenous endogenous JJ cord-023095-4dannjjm 5789 2 plasma plasma NN cord-023095-4dannjjm 5789 3 ACTH ACTH NNP cord-023095-4dannjjm 5789 4 and and CC cord-023095-4dannjjm 5789 5 serum serum NN cord-023095-4dannjjm 5789 6 cortisol cortisol NN cord-023095-4dannjjm 5789 7 concentrations concentration NNS cord-023095-4dannjjm 5789 8 , , , cord-023095-4dannjjm 5789 9 and and CC cord-023095-4dannjjm 5789 10 cortisol cortisol NN cord-023095-4dannjjm 5789 11 at at IN cord-023095-4dannjjm 5789 12 T T NNP cord-023095-4dannjjm 5789 13 5 5 CD cord-023095-4dannjjm 5789 14 0 0 CD cord-023095-4dannjjm 5789 15 and and CC cord-023095-4dannjjm 5789 16 T T NNP cord-023095-4dannjjm 5789 17 5 5 CD cord-023095-4dannjjm 5789 18 30 30 CD cord-023095-4dannjjm 5789 19 min min NN cord-023095-4dannjjm 5789 20 after after IN cord-023095-4dannjjm 5789 21 0.1 0.1 CD cord-023095-4dannjjm 5789 22 mg mg NNP cord-023095-4dannjjm 5789 23 / / SYM cord-023095-4dannjjm 5789 24 kg kg NNP cord-023095-4dannjjm 5789 25 cosyntropin cosyntropin NNP cord-023095-4dannjjm 5789 26 , , , cord-023095-4dannjjm 5789 27 were be VBD cord-023095-4dannjjm 5789 28 measured measure VBN cord-023095-4dannjjm 5789 29 by by IN cord-023095-4dannjjm 5789 30 radioimmunoassay radioimmunoassay JJ cord-023095-4dannjjm 5789 31 from from IN cord-023095-4dannjjm 5789 32 horses horse NNS cord-023095-4dannjjm 5789 33 with with IN cord-023095-4dannjjm 5789 34 colic colic NN cord-023095-4dannjjm 5789 35 or or CC cord-023095-4dannjjm 5789 36 systemic systemic JJ cord-023095-4dannjjm 5789 37 illness illness NN cord-023095-4dannjjm 5789 38 on on IN cord-023095-4dannjjm 5789 39 admission admission NN cord-023095-4dannjjm 5789 40 , , , cord-023095-4dannjjm 5789 41 and and CC cord-023095-4dannjjm 5789 42 days day NNS cord-023095-4dannjjm 5789 43 2 2 CD cord-023095-4dannjjm 5789 44 , , , cord-023095-4dannjjm 5789 45 4 4 CD cord-023095-4dannjjm 5789 46 and and CC cord-023095-4dannjjm 5789 47 6 6 CD cord-023095-4dannjjm 5789 48 of of IN cord-023095-4dannjjm 5789 49 hospitilization hospitilization NN cord-023095-4dannjjm 5789 50 . . . cord-023095-4dannjjm 5790 1 Horses horse NNS cord-023095-4dannjjm 5790 2 were be VBD cord-023095-4dannjjm 5790 3 divided divide VBN cord-023095-4dannjjm 5790 4 into into IN cord-023095-4dannjjm 5790 5 mild mild JJ cord-023095-4dannjjm 5790 6 , , , cord-023095-4dannjjm 5790 7 moderate moderate JJ cord-023095-4dannjjm 5790 8 , , , cord-023095-4dannjjm 5790 9 or or CC cord-023095-4dannjjm 5790 10 severe severe JJ cord-023095-4dannjjm 5790 11 illness illness NN cord-023095-4dannjjm 5790 12 groups group NNS cord-023095-4dannjjm 5790 13 based base VBN cord-023095-4dannjjm 5790 14 on on IN cord-023095-4dannjjm 5790 15 clinicopathologic clinicopathologic NNP cord-023095-4dannjjm 5790 16 data datum NNS cord-023095-4dannjjm 5790 17 . . . cord-023095-4dannjjm 5791 1 Inappropriately inappropriately RB cord-023095-4dannjjm 5791 2 low low JJ cord-023095-4dannjjm 5791 3 cortisol cortisol NN cord-023095-4dannjjm 5791 4 was be VBD cord-023095-4dannjjm 5791 5 defined define VBN cord-023095-4dannjjm 5791 6 as as IN cord-023095-4dannjjm 5791 7 endogenous endogenous JJ cord-023095-4dannjjm 5791 8 cortisol cortisol NN cord-023095-4dannjjm 5791 9 o o NN cord-023095-4dannjjm 5791 10 mean-1SD mean-1SD NNP cord-023095-4dannjjm 5791 11 achieved achieve VBN cord-023095-4dannjjm 5791 12 after after IN cord-023095-4dannjjm 5791 13 administration administration NN cord-023095-4dannjjm 5791 14 of of IN cord-023095-4dannjjm 5791 15 0.1 0.1 CD cord-023095-4dannjjm 5791 16 mg mg NNP cord-023095-4dannjjm 5791 17 / / SYM cord-023095-4dannjjm 5791 18 kg kg NNP cord-023095-4dannjjm 5791 19 cosyntropin cosyntropin NNP cord-023095-4dannjjm 5791 20 to to IN cord-023095-4dannjjm 5791 21 normal normal JJ cord-023095-4dannjjm 5791 22 horses horse NNS cord-023095-4dannjjm 5791 23 ( ( -LRB- cord-023095-4dannjjm 5791 24 o o NN cord-023095-4dannjjm 5791 25 269 269 CD cord-023095-4dannjjm 5791 26 nmol nmol NNP cord-023095-4dannjjm 5791 27 / / SYM cord-023095-4dannjjm 5791 28 L L NNP cord-023095-4dannjjm 5791 29 ) ) -RRB- cord-023095-4dannjjm 5791 30 . . . cord-023095-4dannjjm 5792 1 Inadequate inadequate JJ cord-023095-4dannjjm 5792 2 delta delta NN cord-023095-4dannjjm 5792 3 cortisol cortisol NN cord-023095-4dannjjm 5792 4 was be VBD cord-023095-4dannjjm 5792 5 defined define VBN cord-023095-4dannjjm 5792 6 as as IN cord-023095-4dannjjm 5792 7 o o UH cord-023095-4dannjjm 5792 8 mean mean NN cord-023095-4dannjjm 5792 9 delta delta NN cord-023095-4dannjjm 5792 10 cortisol cortisol NN cord-023095-4dannjjm 5792 11 in in IN cord-023095-4dannjjm 5792 12 normal normal JJ cord-023095-4dannjjm 5792 13 horses horse NNS cord-023095-4dannjjm 5792 14 after after IN cord-023095-4dannjjm 5792 15 0.1 0.1 CD cord-023095-4dannjjm 5792 16 mg mg NNP cord-023095-4dannjjm 5792 17 / / SYM cord-023095-4dannjjm 5792 18 kg kg NNP cord-023095-4dannjjm 5792 19 cosyntropin cosyntropin NNP cord-023095-4dannjjm 5792 20 ( ( -LRB- cord-023095-4dannjjm 5792 21 o o UH cord-023095-4dannjjm 5792 22 159 159 CD cord-023095-4dannjjm 5792 23 nmol nmol NN cord-023095-4dannjjm 5792 24 / / SYM cord-023095-4dannjjm 5792 25 L L NNP cord-023095-4dannjjm 5792 26 ) ) -RRB- cord-023095-4dannjjm 5792 27 . . . cord-023095-4dannjjm 5793 1 Cortisol cortisol NN cord-023095-4dannjjm 5793 2 , , , cord-023095-4dannjjm 5793 3 ACTH ACTH NNP cord-023095-4dannjjm 5793 4 and and CC cord-023095-4dannjjm 5793 5 delta delta NN cord-023095-4dannjjm 5793 6 cortisol cortisol NN cord-023095-4dannjjm 5793 7 were be VBD cord-023095-4dannjjm 5793 8 compared compare VBN cord-023095-4dannjjm 5793 9 using use VBG cord-023095-4dannjjm 5793 10 ANOVA ANOVA NNP cord-023095-4dannjjm 5793 11 between between IN cord-023095-4dannjjm 5793 12 groups group NNS cord-023095-4dannjjm 5793 13 , , , cord-023095-4dannjjm 5793 14 with with IN cord-023095-4dannjjm 5793 15 P p NN cord-023095-4dannjjm 5793 16 o o NN cord-023095-4dannjjm 5793 17 0.05 0.05 CD cord-023095-4dannjjm 5793 18 considered consider VBN cord-023095-4dannjjm 5793 19 significant significant JJ cord-023095-4dannjjm 5793 20 . . . cord-023095-4dannjjm 5794 1 Fifty fifty CD cord-023095-4dannjjm 5794 2 - - HYPH cord-023095-4dannjjm 5794 3 eight eight CD cord-023095-4dannjjm 5794 4 horses horse NNS cord-023095-4dannjjm 5794 5 classified classify VBN cord-023095-4dannjjm 5794 6 as as IN cord-023095-4dannjjm 5794 7 having have VBG cord-023095-4dannjjm 5794 8 mild mild JJ cord-023095-4dannjjm 5794 9 ( ( -LRB- cord-023095-4dannjjm 5794 10 11 11 CD cord-023095-4dannjjm 5794 11 ) ) -RRB- cord-023095-4dannjjm 5794 12 , , , cord-023095-4dannjjm 5794 13 moderate moderate JJ cord-023095-4dannjjm 5794 14 ( ( -LRB- cord-023095-4dannjjm 5794 15 30 30 CD cord-023095-4dannjjm 5794 16 ) ) -RRB- cord-023095-4dannjjm 5794 17 and and CC cord-023095-4dannjjm 5794 18 severe severe JJ cord-023095-4dannjjm 5794 19 ( ( -LRB- cord-023095-4dannjjm 5794 20 17 17 CD cord-023095-4dannjjm 5794 21 ) ) -RRB- cord-023095-4dannjjm 5794 22 disease disease NN cord-023095-4dannjjm 5794 23 at at IN cord-023095-4dannjjm 5794 24 admission admission NN cord-023095-4dannjjm 5794 25 had have VBD cord-023095-4dannjjm 5794 26 survival survival NN cord-023095-4dannjjm 5794 27 rates rate NNS cord-023095-4dannjjm 5794 28 of of IN cord-023095-4dannjjm 5794 29 100 100 CD cord-023095-4dannjjm 5794 30 % % NN cord-023095-4dannjjm 5794 31 , , , cord-023095-4dannjjm 5794 32 97 97 CD cord-023095-4dannjjm 5794 33 % % NN cord-023095-4dannjjm 5794 34 and and CC cord-023095-4dannjjm 5794 35 35 35 CD cord-023095-4dannjjm 5794 36 % % NN cord-023095-4dannjjm 5794 37 respectively respectively RB cord-023095-4dannjjm 5794 38 . . . cord-023095-4dannjjm 5795 1 Admission admission NN cord-023095-4dannjjm 5795 2 ACTH ACTH NNP cord-023095-4dannjjm 5795 3 and and CC cord-023095-4dannjjm 5795 4 cortisol cortisol NN cord-023095-4dannjjm 5795 5 concentrations concentration NNS cord-023095-4dannjjm 5795 6 were be VBD cord-023095-4dannjjm 5795 7 highest high JJS cord-023095-4dannjjm 5795 8 in in IN cord-023095-4dannjjm 5795 9 severely severely RB cord-023095-4dannjjm 5795 10 ill ill JJ cord-023095-4dannjjm 5795 11 horses horse NNS cord-023095-4dannjjm 5795 12 ( ( -LRB- cord-023095-4dannjjm 5795 13 93 93 CD cord-023095-4dannjjm 5795 14 AE AE NNP cord-023095-4dannjjm 5795 15 198pg 198pg NNP cord-023095-4dannjjm 5795 16 / / SYM cord-023095-4dannjjm 5795 17 mL mL NNP cord-023095-4dannjjm 5795 18 , , , cord-023095-4dannjjm 5795 19 361 361 CD cord-023095-4dannjjm 5795 20 AE AE NNP cord-023095-4dannjjm 5795 21 137 137 CD cord-023095-4dannjjm 5795 22 nmol nmol NNP cord-023095-4dannjjm 5795 23 / / SYM cord-023095-4dannjjm 5795 24 L l NN cord-023095-4dannjjm 5795 25 ) ) -RRB- cord-023095-4dannjjm 5795 26 compared compare VBN cord-023095-4dannjjm 5795 27 to to IN cord-023095-4dannjjm 5795 28 moderate moderate JJ cord-023095-4dannjjm 5795 29 ( ( -LRB- cord-023095-4dannjjm 5795 30 31 31 CD cord-023095-4dannjjm 5795 31 AE AE NNP cord-023095-4dannjjm 5795 32 36 36 CD cord-023095-4dannjjm 5795 33 , , , cord-023095-4dannjjm 5795 34 279 279 CD cord-023095-4dannjjm 5795 35 AE AE NNP cord-023095-4dannjjm 5795 36 137 137 CD cord-023095-4dannjjm 5795 37 ) ) -RRB- cord-023095-4dannjjm 5795 38 and and CC cord-023095-4dannjjm 5795 39 mildly mildly RB cord-023095-4dannjjm 5795 40 ill ill JJ cord-023095-4dannjjm 5795 41 horses horse NNS cord-023095-4dannjjm 5795 42 ( ( -LRB- cord-023095-4dannjjm 5795 43 18.0 18.0 CD cord-023095-4dannjjm 5795 44 AE AE NNP cord-023095-4dannjjm 5795 45 12.0 12.0 CD cord-023095-4dannjjm 5795 46 , , , cord-023095-4dannjjm 5795 47 237 237 CD cord-023095-4dannjjm 5795 48 AE AE NNP cord-023095-4dannjjm 5795 49 133 133 CD cord-023095-4dannjjm 5795 50 ) ) -RRB- cord-023095-4dannjjm 5795 51 . . . cord-023095-4dannjjm 5796 1 Admission admission NN cord-023095-4dannjjm 5796 2 cortisol cortisol NN cord-023095-4dannjjm 5796 3 concentrations concentration NNS cord-023095-4dannjjm 5796 4 were be VBD cord-023095-4dannjjm 5796 5 higher high JJR cord-023095-4dannjjm 5796 6 overall overall RB cord-023095-4dannjjm 5796 7 in in IN cord-023095-4dannjjm 5796 8 severely severely RB cord-023095-4dannjjm 5796 9 ill ill JJ cord-023095-4dannjjm 5796 10 horses horse NNS cord-023095-4dannjjm 5796 11 ( ( -LRB- cord-023095-4dannjjm 5796 12 P p NN cord-023095-4dannjjm 5796 13 5 5 CD cord-023095-4dannjjm 5796 14 0.016 0.016 CD cord-023095-4dannjjm 5796 15 ) ) -RRB- cord-023095-4dannjjm 5796 16 , , , cord-023095-4dannjjm 5796 17 but but CC cord-023095-4dannjjm 5796 18 were be VBD cord-023095-4dannjjm 5796 19 low low JJ cord-023095-4dannjjm 5796 20 in in IN cord-023095-4dannjjm 5796 21 24 24 CD cord-023095-4dannjjm 5796 22 % % NN cord-023095-4dannjjm 5796 23 ( ( -LRB- cord-023095-4dannjjm 5796 24 4/17 4/17 CD cord-023095-4dannjjm 5796 25 ) ) -RRB- cord-023095-4dannjjm 5796 26 . . . cord-023095-4dannjjm 5797 1 Admission admission NN cord-023095-4dannjjm 5797 2 delta delta NN cord-023095-4dannjjm 5797 3 cortisol cortisol NN cord-023095-4dannjjm 5797 4 was be VBD cord-023095-4dannjjm 5797 5 low low JJ cord-023095-4dannjjm 5797 6 in in IN cord-023095-4dannjjm 5797 7 85 85 CD cord-023095-4dannjjm 5797 8 % % NN cord-023095-4dannjjm 5797 9 ( ( -LRB- cord-023095-4dannjjm 5797 10 11/13 11/13 CD cord-023095-4dannjjm 5797 11 ) ) -RRB- cord-023095-4dannjjm 5797 12 of of IN cord-023095-4dannjjm 5797 13 severely severely RB cord-023095-4dannjjm 5797 14 ill ill JJ cord-023095-4dannjjm 5797 15 horses horse NNS cord-023095-4dannjjm 5797 16 , , , cord-023095-4dannjjm 5797 17 and and CC cord-023095-4dannjjm 5797 18 was be VBD cord-023095-4dannjjm 5797 19 associated associate VBN cord-023095-4dannjjm 5797 20 with with IN cord-023095-4dannjjm 5797 21 marked marked JJ cord-023095-4dannjjm 5797 22 adrenal adrenal JJ cord-023095-4dannjjm 5797 23 hemorrhage hemorrhage NN cord-023095-4dannjjm 5797 24 in in IN cord-023095-4dannjjm 5797 25 non non NNS cord-023095-4dannjjm 5797 26 - - NNS cord-023095-4dannjjm 5797 27 survivors survivor NNS cord-023095-4dannjjm 5797 28 . . . cord-023095-4dannjjm 5798 1 Severely severely RB cord-023095-4dannjjm 5798 2 ill ill JJ cord-023095-4dannjjm 5798 3 horses horse NNS cord-023095-4dannjjm 5798 4 have have VBP cord-023095-4dannjjm 5798 5 high high JJ cord-023095-4dannjjm 5798 6 cortisol cortisol NN cord-023095-4dannjjm 5798 7 and and CC cord-023095-4dannjjm 5798 8 ACTH ACTH NNP cord-023095-4dannjjm 5798 9 , , , cord-023095-4dannjjm 5798 10 but but CC cord-023095-4dannjjm 5798 11 low low JJ cord-023095-4dannjjm 5798 12 cortisol cortisol NN cord-023095-4dannjjm 5798 13 and and CC cord-023095-4dannjjm 5798 14 delta delta NN cord-023095-4dannjjm 5798 15 cortisol cortisol NN cord-023095-4dannjjm 5798 16 may may MD cord-023095-4dannjjm 5798 17 indicate indicate VB cord-023095-4dannjjm 5798 18 CIRCI CIRCI NNP cord-023095-4dannjjm 5798 19 secondary secondary JJ cord-023095-4dannjjm 5798 20 to to IN cord-023095-4dannjjm 5798 21 adrenal adrenal JJ cord-023095-4dannjjm 5798 22 hemorrhage hemorrhage NN cord-023095-4dannjjm 5798 23 . . . cord-023095-4dannjjm 5799 1 Equine equine JJ cord-023095-4dannjjm 5799 2 pituitary pituitary NN cord-023095-4dannjjm 5799 3 pars pars FW cord-023095-4dannjjm 5799 4 intermedia intermedia NN cord-023095-4dannjjm 5799 5 dysfunction dysfunction NN cord-023095-4dannjjm 5799 6 ( ( -LRB- cord-023095-4dannjjm 5799 7 PPID PPID NNP cord-023095-4dannjjm 5799 8 ) ) -RRB- cord-023095-4dannjjm 5799 9 is be VBZ cord-023095-4dannjjm 5799 10 a a DT cord-023095-4dannjjm 5799 11 common common JJ cord-023095-4dannjjm 5799 12 endocrinopathy endocrinopathy NN cord-023095-4dannjjm 5799 13 of of IN cord-023095-4dannjjm 5799 14 aged aged JJ cord-023095-4dannjjm 5799 15 horses horse NNS cord-023095-4dannjjm 5799 16 that that WDT cord-023095-4dannjjm 5799 17 results result VBZ cord-023095-4dannjjm 5799 18 from from IN cord-023095-4dannjjm 5799 19 neurodegeneration neurodegeneration NN cord-023095-4dannjjm 5799 20 of of IN cord-023095-4dannjjm 5799 21 the the DT cord-023095-4dannjjm 5799 22 dopaminergic dopaminergic JJ cord-023095-4dannjjm 5799 23 periventricular periventricular NNP cord-023095-4dannjjm 5799 24 neurons neuron NNS cord-023095-4dannjjm 5799 25 that that WDT cord-023095-4dannjjm 5799 26 innervate innervate VBP cord-023095-4dannjjm 5799 27 the the DT cord-023095-4dannjjm 5799 28 intermediate intermediate JJ cord-023095-4dannjjm 5799 29 lobe lobe NN cord-023095-4dannjjm 5799 30 of of IN cord-023095-4dannjjm 5799 31 the the DT cord-023095-4dannjjm 5799 32 pituitary pituitary NN cord-023095-4dannjjm 5799 33 . . . cord-023095-4dannjjm 5800 1 Factors factor NNS cord-023095-4dannjjm 5800 2 that that WDT cord-023095-4dannjjm 5800 3 initiate initiate VBP cord-023095-4dannjjm 5800 4 spontaneous spontaneous JJ cord-023095-4dannjjm 5800 5 dopaminergic dopaminergic JJ cord-023095-4dannjjm 5800 6 neurodegenerative neurodegenerative JJ cord-023095-4dannjjm 5800 7 disease disease NN cord-023095-4dannjjm 5800 8 remain remain VBP cord-023095-4dannjjm 5800 9 elusive elusive JJ cord-023095-4dannjjm 5800 10 , , , cord-023095-4dannjjm 5800 11 however however RB cord-023095-4dannjjm 5800 12 accumulation accumulation NN cord-023095-4dannjjm 5800 13 of of IN cord-023095-4dannjjm 5800 14 misfolded misfolde VBN cord-023095-4dannjjm 5800 15 a a DT cord-023095-4dannjjm 5800 16 - - HYPH cord-023095-4dannjjm 5800 17 synuclein synuclein NN cord-023095-4dannjjm 5800 18 protein protein NN cord-023095-4dannjjm 5800 19 and and CC cord-023095-4dannjjm 5800 20 dysfunctional dysfunctional JJ cord-023095-4dannjjm 5800 21 protein protein NN cord-023095-4dannjjm 5800 22 clearance clearance NN cord-023095-4dannjjm 5800 23 have have VBP cord-023095-4dannjjm 5800 24 been be VBN cord-023095-4dannjjm 5800 25 implicated implicate VBN cord-023095-4dannjjm 5800 26 . . . cord-023095-4dannjjm 5801 1 Misfolded Misfolded NNP cord-023095-4dannjjm 5801 2 protein protein NN cord-023095-4dannjjm 5801 3 accumulation accumulation NN cord-023095-4dannjjm 5801 4 occurs occur VBZ cord-023095-4dannjjm 5801 5 due due JJ cord-023095-4dannjjm 5801 6 to to IN cord-023095-4dannjjm 5801 7 increased increase VBN cord-023095-4dannjjm 5801 8 protein protein NN cord-023095-4dannjjm 5801 9 production production NN cord-023095-4dannjjm 5801 10 or or CC cord-023095-4dannjjm 5801 11 decreased decrease VBD cord-023095-4dannjjm 5801 12 clearance clearance NN cord-023095-4dannjjm 5801 13 of of IN cord-023095-4dannjjm 5801 14 damaged damaged JJ cord-023095-4dannjjm 5801 15 macromolecules macromolecule NNS cord-023095-4dannjjm 5801 16 through through IN cord-023095-4dannjjm 5801 17 the the DT cord-023095-4dannjjm 5801 18 process process NN cord-023095-4dannjjm 5801 19 of of IN cord-023095-4dannjjm 5801 20 autophagy autophagy NN cord-023095-4dannjjm 5801 21 . . . cord-023095-4dannjjm 5802 1 While while IN cord-023095-4dannjjm 5802 2 have have VBP cord-023095-4dannjjm 5802 3 previously previously RB cord-023095-4dannjjm 5802 4 demonstrated demonstrate VBN cord-023095-4dannjjm 5802 5 that that IN cord-023095-4dannjjm 5802 6 horses horse NNS cord-023095-4dannjjm 5802 7 with with IN cord-023095-4dannjjm 5802 8 PPID PPID NNP cord-023095-4dannjjm 5802 9 have have VBP cord-023095-4dannjjm 5802 10 increased increase VBN cord-023095-4dannjjm 5802 11 asynuclein asynuclein NNP cord-023095-4dannjjm 5802 12 in in IN cord-023095-4dannjjm 5802 13 the the DT cord-023095-4dannjjm 5802 14 periventricular periventricular NNP cord-023095-4dannjjm 5802 15 neurons neuron NNS cord-023095-4dannjjm 5802 16 compared compare VBN cord-023095-4dannjjm 5802 17 to to IN cord-023095-4dannjjm 5802 18 controls control NNS cord-023095-4dannjjm 5802 19 , , , cord-023095-4dannjjm 5802 20 it -PRON- PRP cord-023095-4dannjjm 5802 21 remains remain VBZ cord-023095-4dannjjm 5802 22 unknown unknown JJ cord-023095-4dannjjm 5802 23 whether whether IN cord-023095-4dannjjm 5802 24 the the DT cord-023095-4dannjjm 5802 25 protein protein NN cord-023095-4dannjjm 5802 26 accumulates accumulate VBZ cord-023095-4dannjjm 5802 27 due due IN cord-023095-4dannjjm 5802 28 to to IN cord-023095-4dannjjm 5802 29 increased increase VBN cord-023095-4dannjjm 5802 30 production production NN cord-023095-4dannjjm 5802 31 or or CC cord-023095-4dannjjm 5802 32 decreased decrease VBD cord-023095-4dannjjm 5802 33 clearance clearance NN cord-023095-4dannjjm 5802 34 . . . cord-023095-4dannjjm 5803 1 We -PRON- PRP cord-023095-4dannjjm 5803 2 hypothesized hypothesize VBD cord-023095-4dannjjm 5803 3 that that IN cord-023095-4dannjjm 5803 4 autophagy autophagy NN cord-023095-4dannjjm 5803 5 is be VBZ cord-023095-4dannjjm 5803 6 decreased decrease VBN cord-023095-4dannjjm 5803 7 in in IN cord-023095-4dannjjm 5803 8 the the DT cord-023095-4dannjjm 5803 9 pituitary pituitary JJ cord-023095-4dannjjm 5803 10 neurointermediate neurointermediate NN cord-023095-4dannjjm 5803 11 lobe lobe NN cord-023095-4dannjjm 5803 12 from from IN cord-023095-4dannjjm 5803 13 horses horse NNS cord-023095-4dannjjm 5803 14 with with IN cord-023095-4dannjjm 5803 15 PPID PPID NNP cord-023095-4dannjjm 5803 16 compared compare VBN cord-023095-4dannjjm 5803 17 to to IN cord-023095-4dannjjm 5803 18 controls control NNS cord-023095-4dannjjm 5803 19 . . . cord-023095-4dannjjm 5804 1 Neurointermediate Neurointermediate NNP cord-023095-4dannjjm 5804 2 lobe lobe NN cord-023095-4dannjjm 5804 3 pituitary pituitary JJ cord-023095-4dannjjm 5804 4 tissue tissue NN cord-023095-4dannjjm 5804 5 was be VBD cord-023095-4dannjjm 5804 6 from from IN cord-023095-4dannjjm 5804 7 collected collect VBN cord-023095-4dannjjm 5804 8 from from IN cord-023095-4dannjjm 5804 9 horses horse NNS cord-023095-4dannjjm 5804 10 with with IN cord-023095-4dannjjm 5804 11 PPID PPID NNP cord-023095-4dannjjm 5804 12 ( ( -LRB- cord-023095-4dannjjm 5804 13 n n NN cord-023095-4dannjjm 5804 14 5 5 CD cord-023095-4dannjjm 5804 15 12 12 CD cord-023095-4dannjjm 5804 16 ) ) -RRB- cord-023095-4dannjjm 5804 17 and and CC cord-023095-4dannjjm 5804 18 healthy healthy JJ cord-023095-4dannjjm 5804 19 horses horse NNS cord-023095-4dannjjm 5804 20 ( ( -LRB- cord-023095-4dannjjm 5804 21 n n NN cord-023095-4dannjjm 5804 22 5 5 CD cord-023095-4dannjjm 5804 23 37 37 CD cord-023095-4dannjjm 5804 24 , , , cord-023095-4dannjjm 5804 25 2 2 CD cord-023095-4dannjjm 5804 26 - - SYM cord-023095-4dannjjm 5804 27 35 35 CD cord-023095-4dannjjm 5804 28 years year NNS cord-023095-4dannjjm 5804 29 ) ) -RRB- cord-023095-4dannjjm 5804 30 . . . cord-023095-4dannjjm 5805 1 Realtime Realtime NNP cord-023095-4dannjjm 5805 2 PCR PCR NNP cord-023095-4dannjjm 5805 3 was be VBD cord-023095-4dannjjm 5805 4 used use VBN cord-023095-4dannjjm 5805 5 to to TO cord-023095-4dannjjm 5805 6 determine determine VB cord-023095-4dannjjm 5805 7 the the DT cord-023095-4dannjjm 5805 8 relative relative JJ cord-023095-4dannjjm 5805 9 expression expression NN cord-023095-4dannjjm 5805 10 of of IN cord-023095-4dannjjm 5805 11 autophagy autophagy NN cord-023095-4dannjjm 5805 12 genes gene NNS cord-023095-4dannjjm 5805 13 ( ( -LRB- cord-023095-4dannjjm 5805 14 mTOR mTOR NNP cord-023095-4dannjjm 5805 15 , , , cord-023095-4dannjjm 5805 16 Beclin1 Beclin1 NNP cord-023095-4dannjjm 5805 17 , , , cord-023095-4dannjjm 5805 18 ATG12 ATG12 NNP cord-023095-4dannjjm 5805 19 , , , cord-023095-4dannjjm 5805 20 ATG7 ATG7 NNP cord-023095-4dannjjm 5805 21 , , , cord-023095-4dannjjm 5805 22 ATG5 ATG5 NNP cord-023095-4dannjjm 5805 23 , , , cord-023095-4dannjjm 5805 24 PINK PINK NNP cord-023095-4dannjjm 5805 25 , , , cord-023095-4dannjjm 5805 26 LAMP2 lamp2 NN cord-023095-4dannjjm 5805 27 ) ) -RRB- cord-023095-4dannjjm 5805 28 and and CC cord-023095-4dannjjm 5805 29 a a DT cord-023095-4dannjjm 5805 30 - - HYPH cord-023095-4dannjjm 5805 31 synuclein synuclein NN cord-023095-4dannjjm 5805 32 Relative relative JJ cord-023095-4dannjjm 5805 33 gene gene NN cord-023095-4dannjjm 5805 34 expression expression NN cord-023095-4dannjjm 5805 35 from from IN cord-023095-4dannjjm 5805 36 horses horse NNS cord-023095-4dannjjm 5805 37 with with IN cord-023095-4dannjjm 5805 38 PPID PPID NNP cord-023095-4dannjjm 5805 39 were be VBD cord-023095-4dannjjm 5805 40 compared compare VBN cord-023095-4dannjjm 5805 41 to to IN cord-023095-4dannjjm 5805 42 healthy healthy JJ cord-023095-4dannjjm 5805 43 horses horse NNS cord-023095-4dannjjm 5805 44 by by IN cord-023095-4dannjjm 5805 45 t t NN cord-023095-4dannjjm 5805 46 - - HYPH cord-023095-4dannjjm 5805 47 test test NN cord-023095-4dannjjm 5805 48 following follow VBG cord-023095-4dannjjm 5805 49 log log NN cord-023095-4dannjjm 5805 50 transformation transformation NN cord-023095-4dannjjm 5805 51 . . . cord-023095-4dannjjm 5806 1 A a DT cord-023095-4dannjjm 5806 2 Pearson Pearson NNP cord-023095-4dannjjm 5806 3 coefficient coefficient NN cord-023095-4dannjjm 5806 4 of of IN cord-023095-4dannjjm 5806 5 correlation correlation NN cord-023095-4dannjjm 5806 6 was be VBD cord-023095-4dannjjm 5806 7 calculated calculate VBN cord-023095-4dannjjm 5806 8 comparing compare VBG cord-023095-4dannjjm 5806 9 a a DT cord-023095-4dannjjm 5806 10 - - HYPH cord-023095-4dannjjm 5806 11 synuclein synuclein NN cord-023095-4dannjjm 5806 12 expression expression NN cord-023095-4dannjjm 5806 13 with with IN cord-023095-4dannjjm 5806 14 autophagy autophagy NN cord-023095-4dannjjm 5806 15 gene gene NN cord-023095-4dannjjm 5806 16 expression expression NN cord-023095-4dannjjm 5806 17 . . . cord-023095-4dannjjm 5807 1 The the DT cord-023095-4dannjjm 5807 2 expression expression NN cord-023095-4dannjjm 5807 3 of of IN cord-023095-4dannjjm 5807 4 a a DT cord-023095-4dannjjm 5807 5 - - HYPH cord-023095-4dannjjm 5807 6 synuclein synuclein NN cord-023095-4dannjjm 5807 7 , , , cord-023095-4dannjjm 5807 8 autophagy autophagy NN cord-023095-4dannjjm 5807 9 - - HYPH cord-023095-4dannjjm 5807 10 related relate VBN cord-023095-4dannjjm 5807 11 genes gene NNS cord-023095-4dannjjm 5807 12 ( ( -LRB- cord-023095-4dannjjm 5807 13 ATG12 ATG12 NNP cord-023095-4dannjjm 5807 14 , , , cord-023095-4dannjjm 5807 15 Beclin Beclin NNP cord-023095-4dannjjm 5807 16 , , , cord-023095-4dannjjm 5807 17 Lamp2 Lamp2 NNP cord-023095-4dannjjm 5807 18 ) ) -RRB- cord-023095-4dannjjm 5807 19 , , , cord-023095-4dannjjm 5807 20 and and CC cord-023095-4dannjjm 5807 21 mTOR mTOR NNP cord-023095-4dannjjm 5807 22 was be VBD cord-023095-4dannjjm 5807 23 greater great JJR cord-023095-4dannjjm 5807 24 in in IN cord-023095-4dannjjm 5807 25 horses horse NNS cord-023095-4dannjjm 5807 26 with with IN cord-023095-4dannjjm 5807 27 PPID PPID NNP cord-023095-4dannjjm 5807 28 than than IN cord-023095-4dannjjm 5807 29 in in IN cord-023095-4dannjjm 5807 30 healthy healthy JJ cord-023095-4dannjjm 5807 31 horses horse NNS cord-023095-4dannjjm 5807 32 . . . cord-023095-4dannjjm 5808 1 Age age NN cord-023095-4dannjjm 5808 2 was be VBD cord-023095-4dannjjm 5808 3 not not RB cord-023095-4dannjjm 5808 4 correlated correlate VBN cord-023095-4dannjjm 5808 5 to to IN cord-023095-4dannjjm 5808 6 a a DT cord-023095-4dannjjm 5808 7 - - HYPH cord-023095-4dannjjm 5808 8 synuclein synuclein NN cord-023095-4dannjjm 5808 9 or or CC cord-023095-4dannjjm 5808 10 autophagy autophagy NN cord-023095-4dannjjm 5808 11 gene gene NN cord-023095-4dannjjm 5808 12 expression expression NN cord-023095-4dannjjm 5808 13 . . . cord-023095-4dannjjm 5809 1 There there EX cord-023095-4dannjjm 5809 2 was be VBD cord-023095-4dannjjm 5809 3 a a DT cord-023095-4dannjjm 5809 4 significant significant JJ cord-023095-4dannjjm 5809 5 positive positive JJ cord-023095-4dannjjm 5809 6 correlation correlation NN cord-023095-4dannjjm 5809 7 between between IN cord-023095-4dannjjm 5809 8 expression expression NN cord-023095-4dannjjm 5809 9 of of IN cord-023095-4dannjjm 5809 10 a a DT cord-023095-4dannjjm 5809 11 - - HYPH cord-023095-4dannjjm 5809 12 synuclein synuclein NN cord-023095-4dannjjm 5809 13 and and CC cord-023095-4dannjjm 5809 14 Beclin1 Beclin1 NNP cord-023095-4dannjjm 5809 15 , , , cord-023095-4dannjjm 5809 16 ATG12 ATG12 NNP cord-023095-4dannjjm 5809 17 , , , cord-023095-4dannjjm 5809 18 ATG7 ATG7 NNP cord-023095-4dannjjm 5809 19 , , , cord-023095-4dannjjm 5809 20 ATG5 ATG5 NNP cord-023095-4dannjjm 5809 21 , , , cord-023095-4dannjjm 5809 22 and and CC cord-023095-4dannjjm 5809 23 PINK PINK NNP cord-023095-4dannjjm 5809 24 , , , cord-023095-4dannjjm 5809 25 but but CC cord-023095-4dannjjm 5809 26 not not RB cord-023095-4dannjjm 5809 27 mTOR mTOR NNP cord-023095-4dannjjm 5809 28 expression expression NN cord-023095-4dannjjm 5809 29 . . . cord-023095-4dannjjm 5810 1 Accumulation accumulation NN cord-023095-4dannjjm 5810 2 of of IN cord-023095-4dannjjm 5810 3 a a DT cord-023095-4dannjjm 5810 4 - - HYPH cord-023095-4dannjjm 5810 5 synuclein synuclein NN cord-023095-4dannjjm 5810 6 protein protein NN cord-023095-4dannjjm 5810 7 in in IN cord-023095-4dannjjm 5810 8 horses horse NNS cord-023095-4dannjjm 5810 9 with with IN cord-023095-4dannjjm 5810 10 PPID PPID NNP cord-023095-4dannjjm 5810 11 may may MD cord-023095-4dannjjm 5810 12 result result VB cord-023095-4dannjjm 5810 13 from from IN cord-023095-4dannjjm 5810 14 increased increase VBN cord-023095-4dannjjm 5810 15 a a DT cord-023095-4dannjjm 5810 16 - - HYPH cord-023095-4dannjjm 5810 17 synuclein synuclein NN cord-023095-4dannjjm 5810 18 expression expression NN cord-023095-4dannjjm 5810 19 . . . cord-023095-4dannjjm 5811 1 Autophagy Autophagy NNP cord-023095-4dannjjm 5811 2 genes gene NNS cord-023095-4dannjjm 5811 3 are be VBP cord-023095-4dannjjm 5811 4 upregulated upregulate VBN cord-023095-4dannjjm 5811 5 in in IN cord-023095-4dannjjm 5811 6 horses horse NNS cord-023095-4dannjjm 5811 7 with with IN cord-023095-4dannjjm 5811 8 PPID PPID NNP cord-023095-4dannjjm 5811 9 , , , cord-023095-4dannjjm 5811 10 suggesting suggest VBG cord-023095-4dannjjm 5811 11 a a DT cord-023095-4dannjjm 5811 12 compensatory compensatory JJ cord-023095-4dannjjm 5811 13 response response NN cord-023095-4dannjjm 5811 14 , , , cord-023095-4dannjjm 5811 15 although although IN cord-023095-4dannjjm 5811 16 these these DT cord-023095-4dannjjm 5811 17 findings finding NNS cord-023095-4dannjjm 5811 18 need need VBP cord-023095-4dannjjm 5811 19 to to TO cord-023095-4dannjjm 5811 20 be be VB cord-023095-4dannjjm 5811 21 confirmed confirm VBN cord-023095-4dannjjm 5811 22 by by IN cord-023095-4dannjjm 5811 23 demonstrating demonstrate VBG cord-023095-4dannjjm 5811 24 an an DT cord-023095-4dannjjm 5811 25 increased increase VBN cord-023095-4dannjjm 5811 26 functional functional JJ cord-023095-4dannjjm 5811 27 response response NN cord-023095-4dannjjm 5811 28 . . . cord-023095-4dannjjm 5812 1 asynuclein asynuclein NNP cord-023095-4dannjjm 5812 2 expression expression NN cord-023095-4dannjjm 5812 3 was be VBD cord-023095-4dannjjm 5812 4 positively positively RB cord-023095-4dannjjm 5812 5 correlated correlate VBN cord-023095-4dannjjm 5812 6 to to IN cord-023095-4dannjjm 5812 7 expression expression NN cord-023095-4dannjjm 5812 8 of of IN cord-023095-4dannjjm 5812 9 autophagy autophagy NN cord-023095-4dannjjm 5812 10 genes gene NNS cord-023095-4dannjjm 5812 11 except except IN cord-023095-4dannjjm 5812 12 mTOR mTOR NNP cord-023095-4dannjjm 5812 13 , , , cord-023095-4dannjjm 5812 14 suggesting suggest VBG cord-023095-4dannjjm 5812 15 a a DT cord-023095-4dannjjm 5812 16 - - HYPH cord-023095-4dannjjm 5812 17 synuclein synuclein NN cord-023095-4dannjjm 5812 18 may may MD cord-023095-4dannjjm 5812 19 stimulate stimulate VB cord-023095-4dannjjm 5812 20 autophagy autophagy NN cord-023095-4dannjjm 5812 21 in in IN cord-023095-4dannjjm 5812 22 an an DT cord-023095-4dannjjm 5812 23 mTOR mTOR NNP cord-023095-4dannjjm 5812 24 independent independent JJ cord-023095-4dannjjm 5812 25 manner manner NN cord-023095-4dannjjm 5812 26 . . . cord-023095-4dannjjm 5813 1 ACVIM ACVIM NNP cord-023095-4dannjjm 5813 2 FORUM forum NN cord-023095-4dannjjm 5813 3 SESSION session NN cord-023095-4dannjjm 5814 1 86A 86A NNS cord-023095-4dannjjm 5814 2 EFFICACY efficacy NN cord-023095-4dannjjm 5814 3 OF of IN cord-023095-4dannjjm 5814 4 DELAYED delay VBN cord-023095-4dannjjm 5814 5 ANTIVIRAL antiviral JJ cord-023095-4dannjjm 5814 6 THERAPY therapy NN cord-023095-4dannjjm 5814 7 AGAINST against IN cord-023095-4dannjjm 5814 8 EHV-1 EHV-1 NNP cord-023095-4dannjjm 5814 9 CHALLENGE CHALLENGE NNS cord-023095-4dannjjm 5814 10 . . . cord-023095-4dannjjm 5815 1 LK LK NNP cord-023095-4dannjjm 5815 2 Maxwell Maxwell NNP cord-023095-4dannjjm 5815 3 1 1 CD cord-023095-4dannjjm 5815 4 , , , cord-023095-4dannjjm 5815 5 LL LL NNP cord-023095-4dannjjm 5815 6 Gilliam Gilliam NNP cord-023095-4dannjjm 5815 7 1 1 CD cord-023095-4dannjjm 5815 8 , , , cord-023095-4dannjjm 5815 9 N N NNP cord-023095-4dannjjm 5815 10 Pusterla Pusterla NNP cord-023095-4dannjjm 5815 11 2 2 CD cord-023095-4dannjjm 5815 12 , , , cord-023095-4dannjjm 5815 13 R R NNP cord-023095-4dannjjm 5815 14 Carmichael Carmichael NNP cord-023095-4dannjjm 5815 15 1 1 CD cord-023095-4dannjjm 5815 16 , , , cord-023095-4dannjjm 5815 17 RW RW NNP cord-023095-4dannjjm 5815 18 Eberle Eberle NNP cord-023095-4dannjjm 5815 19 1 1 CD cord-023095-4dannjjm 5815 20 , , , cord-023095-4dannjjm 5815 21 JW JW NNP cord-023095-4dannjjm 5815 22 Ritchey Ritchey NNP cord-023095-4dannjjm 5815 23 1 1 CD cord-023095-4dannjjm 5815 24 , , , cord-023095-4dannjjm 5815 25 TC TC NNP cord-023095-4dannjjm 5815 26 Holbrook Holbrook NNP cord-023095-4dannjjm 5815 27 1 1 CD cord-023095-4dannjjm 5815 28 , , , cord-023095-4dannjjm 5815 29 T T NNP cord-023095-4dannjjm 5815 30 Gull Gull NNP cord-023095-4dannjjm 5815 31 1 1 CD cord-023095-4dannjjm 5815 32 , , , cord-023095-4dannjjm 5815 33 GB GB NNP cord-023095-4dannjjm 5815 34 Rezabek Rezabek NNP cord-023095-4dannjjm 5815 35 1 1 CD cord-023095-4dannjjm 5815 36 , , , cord-023095-4dannjjm 5815 37 D D NNP cord-023095-4dannjjm 5815 38 McFarlane McFarlane NNP cord-023095-4dannjjm 5815 39 1 1 CD cord-023095-4dannjjm 5815 40 , , , cord-023095-4dannjjm 5815 41 CG CG NNP cord-023095-4dannjjm 5815 42 MacAllister MacAllister NNP cord-023095-4dannjjm 5815 43 1 1 CD cord-023095-4dannjjm 5815 44 . . . cord-023095-4dannjjm 5816 1 1 1 CD cord-023095-4dannjjm 5816 2 Oklahoma Oklahoma NNP cord-023095-4dannjjm 5816 3 State State NNP cord-023095-4dannjjm 5816 4 University University NNP cord-023095-4dannjjm 5816 5 , , , cord-023095-4dannjjm 5816 6 Stillwater Stillwater NNP cord-023095-4dannjjm 5816 7 , , , cord-023095-4dannjjm 5816 8 OK ok UH cord-023095-4dannjjm 5816 9 . . . cord-023095-4dannjjm 5817 1 2 2 CD cord-023095-4dannjjm 5817 2 University University NNP cord-023095-4dannjjm 5817 3 of of IN cord-023095-4dannjjm 5817 4 California California NNP cord-023095-4dannjjm 5817 5 , , , cord-023095-4dannjjm 5817 6 Davis Davis NNP cord-023095-4dannjjm 5817 7 , , , cord-023095-4dannjjm 5817 8 CA CA NNP cord-023095-4dannjjm 5817 9 . . . cord-023095-4dannjjm 5818 1 Equine equine JJ cord-023095-4dannjjm 5818 2 herpes herpe NNS cord-023095-4dannjjm 5818 3 virus virus NN cord-023095-4dannjjm 5818 4 type-1 type-1 NN cord-023095-4dannjjm 5818 5 ( ( -LRB- cord-023095-4dannjjm 5818 6 EHV-1 EHV-1 NNP cord-023095-4dannjjm 5818 7 ) ) -RRB- cord-023095-4dannjjm 5818 8 outbreaks outbreak NNS cord-023095-4dannjjm 5818 9 are be VBP cord-023095-4dannjjm 5818 10 often often RB cord-023095-4dannjjm 5818 11 not not RB cord-023095-4dannjjm 5818 12 recognized recognize VBN cord-023095-4dannjjm 5818 13 until until IN cord-023095-4dannjjm 5818 14 exposed expose VBN cord-023095-4dannjjm 5818 15 horses horse NNS cord-023095-4dannjjm 5818 16 are be VBP cord-023095-4dannjjm 5818 17 at at IN cord-023095-4dannjjm 5818 18 immediate immediate JJ cord-023095-4dannjjm 5818 19 risk risk NN cord-023095-4dannjjm 5818 20 for for IN cord-023095-4dannjjm 5818 21 developing develop VBG cord-023095-4dannjjm 5818 22 equine equine JJ cord-023095-4dannjjm 5818 23 herpes herpes NN cord-023095-4dannjjm 5818 24 myeloencephalopathy myeloencephalopathy NNP cord-023095-4dannjjm 5818 25 ( ( -LRB- cord-023095-4dannjjm 5818 26 EHM ehm UH cord-023095-4dannjjm 5818 27 ) ) -RRB- cord-023095-4dannjjm 5818 28 . . . cord-023095-4dannjjm 5819 1 The the DT cord-023095-4dannjjm 5819 2 objective objective NN cord-023095-4dannjjm 5819 3 of of IN cord-023095-4dannjjm 5819 4 this this DT cord-023095-4dannjjm 5819 5 study study NN cord-023095-4dannjjm 5819 6 was be VBD cord-023095-4dannjjm 5819 7 to to TO cord-023095-4dannjjm 5819 8 determine determine VB cord-023095-4dannjjm 5819 9 whether whether IN cord-023095-4dannjjm 5819 10 delayed delay VBN cord-023095-4dannjjm 5819 11 therapy therapy NN cord-023095-4dannjjm 5819 12 with with IN cord-023095-4dannjjm 5819 13 the the DT cord-023095-4dannjjm 5819 14 antiviral antiviral JJ cord-023095-4dannjjm 5819 15 drugs drug NNS cord-023095-4dannjjm 5819 16 valacyclovir valacyclovir NNP cord-023095-4dannjjm 5819 17 or or CC cord-023095-4dannjjm 5819 18 ganciclovir ganciclovir NNP cord-023095-4dannjjm 5819 19 could could MD cord-023095-4dannjjm 5819 20 protect protect VB cord-023095-4dannjjm 5819 21 those those DT cord-023095-4dannjjm 5819 22 horses horse NNS cord-023095-4dannjjm 5819 23 most most RBS cord-023095-4dannjjm 5819 24 at at IN cord-023095-4dannjjm 5819 25 risk risk NN cord-023095-4dannjjm 5819 26 for for IN cord-023095-4dannjjm 5819 27 EHM EHM NNP cord-023095-4dannjjm 5819 28 . . . cord-023095-4dannjjm 5820 1 Eighteen eighteen CD cord-023095-4dannjjm 5820 2 aged aged JJ cord-023095-4dannjjm 5820 3 ( ( -LRB- cord-023095-4dannjjm 5820 4 4 4 CD cord-023095-4dannjjm 5820 5 20 20 CD cord-023095-4dannjjm 5820 6 years year NNS cord-023095-4dannjjm 5820 7 ) ) -RRB- cord-023095-4dannjjm 5820 8 mares mare NNS cord-023095-4dannjjm 5820 9 were be VBD cord-023095-4dannjjm 5820 10 randomized randomize VBN cord-023095-4dannjjm 5820 11 to to IN cord-023095-4dannjjm 5820 12 treatment treatment NN cord-023095-4dannjjm 5820 13 : : : cord-023095-4dannjjm 5820 14 no no DT cord-023095-4dannjjm 5820 15 therapy therapy NN cord-023095-4dannjjm 5820 16 ( ( -LRB- cord-023095-4dannjjm 5820 17 control control NN cord-023095-4dannjjm 5820 18 ) ) -RRB- cord-023095-4dannjjm 5820 19 , , , cord-023095-4dannjjm 5820 20 oral oral JJ cord-023095-4dannjjm 5820 21 valacyclovir valacyclovir NNP cord-023095-4dannjjm 5820 22 therapy therapy NN cord-023095-4dannjjm 5820 23 , , , cord-023095-4dannjjm 5820 24 or or CC cord-023095-4dannjjm 5820 25 intravenous intravenous JJ cord-023095-4dannjjm 5820 26 ganciclovir ganciclovir NN cord-023095-4dannjjm 5820 27 therapy therapy NN cord-023095-4dannjjm 5820 28 . . . cord-023095-4dannjjm 5821 1 Drug Drug NNP cord-023095-4dannjjm 5821 2 administration administration NN cord-023095-4dannjjm 5821 3 was be VBD cord-023095-4dannjjm 5821 4 initiated initiate VBN cord-023095-4dannjjm 5821 5 at at IN cord-023095-4dannjjm 5821 6 the the DT cord-023095-4dannjjm 5821 7 onset onset NN cord-023095-4dannjjm 5821 8 of of IN cord-023095-4dannjjm 5821 9 the the DT cord-023095-4dannjjm 5821 10 second second JJ cord-023095-4dannjjm 5821 11 febrile febrile JJ cord-023095-4dannjjm 5821 12 phase phase NN cord-023095-4dannjjm 5821 13 , , , cord-023095-4dannjjm 5821 14 between between IN cord-023095-4dannjjm 5821 15 days day NNS cord-023095-4dannjjm 5821 16 4 4 CD cord-023095-4dannjjm 5821 17 - - SYM cord-023095-4dannjjm 5821 18 6 6 CD cord-023095-4dannjjm 5821 19 after after IN cord-023095-4dannjjm 5821 20 EHV-1 EHV-1 NNP cord-023095-4dannjjm 5821 21 inoculation inoculation NN cord-023095-4dannjjm 5821 22 ( ( -LRB- cord-023095-4dannjjm 5821 23 PI PI NNP cord-023095-4dannjjm 5821 24 ) ) -RRB- cord-023095-4dannjjm 5821 25 , , , cord-023095-4dannjjm 5821 26 and and CC cord-023095-4dannjjm 5821 27 continued continue VBD cord-023095-4dannjjm 5821 28 for for IN cord-023095-4dannjjm 5821 29 one one CD cord-023095-4dannjjm 5821 30 week week NN cord-023095-4dannjjm 5821 31 . . . cord-023095-4dannjjm 5822 1 Neurological neurological JJ cord-023095-4dannjjm 5822 2 examinations examination NNS cord-023095-4dannjjm 5822 3 were be VBD cord-023095-4dannjjm 5822 4 performed perform VBN cord-023095-4dannjjm 5822 5 prior prior RB cord-023095-4dannjjm 5822 6 to to IN cord-023095-4dannjjm 5822 7 the the DT cord-023095-4dannjjm 5822 8 study study NN cord-023095-4dannjjm 5822 9 and and CC cord-023095-4dannjjm 5822 10 for for IN cord-023095-4dannjjm 5822 11 three three CD cord-023095-4dannjjm 5822 12 weeks week NNS cord-023095-4dannjjm 5822 13 PI pi NN cord-023095-4dannjjm 5822 14 . . . cord-023095-4dannjjm 5823 1 One one CD cord-023095-4dannjjm 5823 2 horse horse NN cord-023095-4dannjjm 5823 3 was be VBD cord-023095-4dannjjm 5823 4 excluded exclude VBN cord-023095-4dannjjm 5823 5 from from IN cord-023095-4dannjjm 5823 6 the the DT cord-023095-4dannjjm 5823 7 study study NN cord-023095-4dannjjm 5823 8 for for IN cord-023095-4dannjjm 5823 9 failure failure NN cord-023095-4dannjjm 5823 10 to to TO cord-023095-4dannjjm 5823 11 become become VB cord-023095-4dannjjm 5823 12 febrile febrile JJ cord-023095-4dannjjm 5823 13 . . . cord-023095-4dannjjm 5824 1 Body body NN cord-023095-4dannjjm 5824 2 temperature temperature NN cord-023095-4dannjjm 5824 3 was be VBD cord-023095-4dannjjm 5824 4 significantly significantly RB cord-023095-4dannjjm 5824 5 lower low JJR cord-023095-4dannjjm 5824 6 in in IN cord-023095-4dannjjm 5824 7 the the DT cord-023095-4dannjjm 5824 8 ganciclovirtherapy ganciclovirtherapy NN cord-023095-4dannjjm 5824 9 horses horse NNS cord-023095-4dannjjm 5824 10 as as IN cord-023095-4dannjjm 5824 11 compared compare VBN cord-023095-4dannjjm 5824 12 to to TO cord-023095-4dannjjm 5824 13 control control VB cord-023095-4dannjjm 5824 14 horses horse NNS cord-023095-4dannjjm 5824 15 on on IN cord-023095-4dannjjm 5824 16 days day NNS cord-023095-4dannjjm 5824 17 6 6 CD cord-023095-4dannjjm 5824 18 - - SYM cord-023095-4dannjjm 5824 19 8 8 CD cord-023095-4dannjjm 5824 20 PI pi NN cord-023095-4dannjjm 5824 21 ( ( -LRB- cord-023095-4dannjjm 5824 22 P p NN cord-023095-4dannjjm 5824 23 o o NN cord-023095-4dannjjm 5824 24 0.05 0.05 CD cord-023095-4dannjjm 5824 25 ) ) -RRB- cord-023095-4dannjjm 5824 26 , , , cord-023095-4dannjjm 5824 27 whereas whereas IN cord-023095-4dannjjm 5824 28 valacyclovir valacyclovir NNP cord-023095-4dannjjm 5824 29 - - HYPH cord-023095-4dannjjm 5824 30 therapy therapy NN cord-023095-4dannjjm 5824 31 horses horse NNS cord-023095-4dannjjm 5824 32 did do VBD cord-023095-4dannjjm 5824 33 not not RB cord-023095-4dannjjm 5824 34 differ differ VB cord-023095-4dannjjm 5824 35 from from IN cord-023095-4dannjjm 5824 36 control control NN cord-023095-4dannjjm 5824 37 horses horse NNS cord-023095-4dannjjm 5824 38 . . . cord-023095-4dannjjm 5825 1 Viremia Viremia NNP cord-023095-4dannjjm 5825 2 in in IN cord-023095-4dannjjm 5825 3 whole whole JJ cord-023095-4dannjjm 5825 4 blood blood NN cord-023095-4dannjjm 5825 5 , , , cord-023095-4dannjjm 5825 6 as as IN cord-023095-4dannjjm 5825 7 determined determine VBN cord-023095-4dannjjm 5825 8 by by IN cord-023095-4dannjjm 5825 9 PCR PCR NNP cord-023095-4dannjjm 5825 10 , , , cord-023095-4dannjjm 5825 11 was be VBD cord-023095-4dannjjm 5825 12 also also RB cord-023095-4dannjjm 5825 13 lower low JJR cord-023095-4dannjjm 5825 14 in in IN cord-023095-4dannjjm 5825 15 the the DT cord-023095-4dannjjm 5825 16 ganciclovir ganciclovir NN cord-023095-4dannjjm 5825 17 - - HYPH cord-023095-4dannjjm 5825 18 therapy therapy NN cord-023095-4dannjjm 5825 19 horses horse NNS cord-023095-4dannjjm 5825 20 on on IN cord-023095-4dannjjm 5825 21 days day NNS cord-023095-4dannjjm 5825 22 7 7 CD cord-023095-4dannjjm 5825 23 - - SYM cord-023095-4dannjjm 5825 24 10 10 CD cord-023095-4dannjjm 5825 25 PI pi NN cord-023095-4dannjjm 5825 26 and and CC cord-023095-4dannjjm 5825 27 on on IN cord-023095-4dannjjm 5825 28 day day NN cord-023095-4dannjjm 5825 29 7 7 CD cord-023095-4dannjjm 5825 30 PI pi NN cord-023095-4dannjjm 5825 31 in in IN cord-023095-4dannjjm 5825 32 the the DT cord-023095-4dannjjm 5825 33 valacyclovir valacyclovir NNP cord-023095-4dannjjm 5825 34 - - HYPH cord-023095-4dannjjm 5825 35 therapy therapy NN cord-023095-4dannjjm 5825 36 horses horse NNS cord-023095-4dannjjm 5826 1 ( ( -LRB- cord-023095-4dannjjm 5826 2 P p NN cord-023095-4dannjjm 5826 3 o o NN cord-023095-4dannjjm 5826 4 0.05 0.05 CD cord-023095-4dannjjm 5826 5 ) ) -RRB- cord-023095-4dannjjm 5826 6 . . . cord-023095-4dannjjm 5827 1 Although although IN cord-023095-4dannjjm 5827 2 antiviral antiviral JJ cord-023095-4dannjjm 5827 3 drug drug NN cord-023095-4dannjjm 5827 4 administration administration NNP cord-023095-4dannjjm 5827 5 did do VBD cord-023095-4dannjjm 5827 6 not not RB cord-023095-4dannjjm 5827 7 reduce reduce VB cord-023095-4dannjjm 5827 8 the the DT cord-023095-4dannjjm 5827 9 risk risk NN cord-023095-4dannjjm 5827 10 of of IN cord-023095-4dannjjm 5827 11 ataxia ataxia NN cord-023095-4dannjjm 5827 12 ( ( -LRB- cord-023095-4dannjjm 5827 13 P p NN cord-023095-4dannjjm 5827 14 5 5 CD cord-023095-4dannjjm 5827 15 0.06 0.06 CD cord-023095-4dannjjm 5827 16 ) ) -RRB- cord-023095-4dannjjm 5827 17 or or CC cord-023095-4dannjjm 5827 18 nasal nasal NN cord-023095-4dannjjm 5827 19 shedding shedding NN cord-023095-4dannjjm 5827 20 , , , cord-023095-4dannjjm 5827 21 ganciclovir ganciclovir NNP cord-023095-4dannjjm 5827 22 therapy therapy NN cord-023095-4dannjjm 5827 23 did do VBD cord-023095-4dannjjm 5827 24 decrease decrease VB cord-023095-4dannjjm 5827 25 the the DT cord-023095-4dannjjm 5827 26 severity severity NN cord-023095-4dannjjm 5827 27 of of IN cord-023095-4dannjjm 5827 28 ataxia ataxia NN cord-023095-4dannjjm 5827 29 ( ( -LRB- cord-023095-4dannjjm 5827 30 P p NN cord-023095-4dannjjm 5827 31 o o NN cord-023095-4dannjjm 5827 32 0.05 0.05 CD cord-023095-4dannjjm 5827 33 ) ) -RRB- cord-023095-4dannjjm 5827 34 as as IN cord-023095-4dannjjm 5827 35 compared compare VBN cord-023095-4dannjjm 5827 36 to to IN cord-023095-4dannjjm 5827 37 valacyclovir valacyclovir NNP cord-023095-4dannjjm 5827 38 - - HYPH cord-023095-4dannjjm 5827 39 therapy therapy NN cord-023095-4dannjjm 5827 40 and and CC cord-023095-4dannjjm 5827 41 control control NN cord-023095-4dannjjm 5827 42 horses horse NNS cord-023095-4dannjjm 5827 43 , , , cord-023095-4dannjjm 5827 44 where where WRB cord-023095-4dannjjm 5827 45 0/6 0/6 CD cord-023095-4dannjjm 5827 46 , , , cord-023095-4dannjjm 5827 47 2/5 2/5 CD cord-023095-4dannjjm 5827 48 , , , cord-023095-4dannjjm 5827 49 and and CC cord-023095-4dannjjm 5827 50 4/6 4/6 CD cord-023095-4dannjjm 5827 51 horses horse NNS cord-023095-4dannjjm 5827 52 , , , cord-023095-4dannjjm 5827 53 respectively respectively RB cord-023095-4dannjjm 5827 54 , , , cord-023095-4dannjjm 5827 55 developed develop VBN cord-023095-4dannjjm 5827 56 at at IN cord-023095-4dannjjm 5827 57 least least JJS cord-023095-4dannjjm 5827 58 a a DT cord-023095-4dannjjm 5827 59 two two CD cord-023095-4dannjjm 5827 60 grade grade NN cord-023095-4dannjjm 5827 61 change change NN cord-023095-4dannjjm 5827 62 in in IN cord-023095-4dannjjm 5827 63 ataxia ataxia NN cord-023095-4dannjjm 5827 64 . . . cord-023095-4dannjjm 5828 1 In in IN cord-023095-4dannjjm 5828 2 summary summary NN cord-023095-4dannjjm 5828 3 , , , cord-023095-4dannjjm 5828 4 ganciclovir ganciclovir NNP cord-023095-4dannjjm 5828 5 administration administration NN cord-023095-4dannjjm 5828 6 provided provide VBD cord-023095-4dannjjm 5828 7 better well JJR cord-023095-4dannjjm 5828 8 protection protection NN cord-023095-4dannjjm 5828 9 against against IN cord-023095-4dannjjm 5828 10 EHM EHM NNP cord-023095-4dannjjm 5828 11 than than IN cord-023095-4dannjjm 5828 12 did do VBD cord-023095-4dannjjm 5828 13 valacyclovir valacyclovir NNP cord-023095-4dannjjm 5828 14 when when WRB cord-023095-4dannjjm 5828 15 therapy therapy NN cord-023095-4dannjjm 5828 16 was be VBD cord-023095-4dannjjm 5828 17 initiated initiate VBN cord-023095-4dannjjm 5828 18 just just RB cord-023095-4dannjjm 5828 19 prior prior RB cord-023095-4dannjjm 5828 20 to to IN cord-023095-4dannjjm 5828 21 the the DT cord-023095-4dannjjm 5828 22 onset onset NN cord-023095-4dannjjm 5828 23 of of IN cord-023095-4dannjjm 5828 24 neurological neurological JJ cord-023095-4dannjjm 5828 25 disease disease NN cord-023095-4dannjjm 5828 26 . . . cord-023095-4dannjjm 5829 1 Equine equine JJ cord-023095-4dannjjm 5829 2 vaccination vaccination NN cord-023095-4dannjjm 5829 3 is be VBZ cord-023095-4dannjjm 5829 4 amongst amongst IN cord-023095-4dannjjm 5829 5 the the DT cord-023095-4dannjjm 5829 6 most most RBS cord-023095-4dannjjm 5829 7 important important JJ cord-023095-4dannjjm 5829 8 method method NN cord-023095-4dannjjm 5829 9 of of IN cord-023095-4dannjjm 5829 10 prophylaxis prophylaxis NN cord-023095-4dannjjm 5829 11 against against IN cord-023095-4dannjjm 5829 12 equine equine JJ cord-023095-4dannjjm 5829 13 influenza influenza NN cord-023095-4dannjjm 5829 14 virus virus NN cord-023095-4dannjjm 5829 15 ( ( -LRB- cord-023095-4dannjjm 5829 16 EIV EIV NNP cord-023095-4dannjjm 5829 17 ) ) -RRB- cord-023095-4dannjjm 5829 18 , , , cord-023095-4dannjjm 5829 19 a a DT cord-023095-4dannjjm 5829 20 pathogen pathogen NN cord-023095-4dannjjm 5829 21 in in IN cord-023095-4dannjjm 5829 22 which which WDT cord-023095-4dannjjm 5829 23 continuous continuous JJ cord-023095-4dannjjm 5829 24 antigenic antigenic JJ cord-023095-4dannjjm 5829 25 drift drift NN cord-023095-4dannjjm 5829 26 can can MD cord-023095-4dannjjm 5829 27 lead lead VB cord-023095-4dannjjm 5829 28 to to IN cord-023095-4dannjjm 5829 29 vaccine vaccine NN cord-023095-4dannjjm 5829 30 failure failure NN cord-023095-4dannjjm 5829 31 . . . cord-023095-4dannjjm 5830 1 A a DT cord-023095-4dannjjm 5830 2 6month 6month JJ cord-023095-4dannjjm 5830 3 duration duration NN cord-023095-4dannjjm 5830 4 of of IN cord-023095-4dannjjm 5830 5 immunity immunity NN cord-023095-4dannjjm 5830 6 ( ( -LRB- cord-023095-4dannjjm 5830 7 DOI DOI NNP cord-023095-4dannjjm 5830 8 ) ) -RRB- cord-023095-4dannjjm 5830 9 challenge challenge NN cord-023095-4dannjjm 5830 10 infection infection NN cord-023095-4dannjjm 5830 11 study study NN cord-023095-4dannjjm 5830 12 was be VBD cord-023095-4dannjjm 5830 13 conducted conduct VBN cord-023095-4dannjjm 5830 14 using use VBG cord-023095-4dannjjm 5830 15 commercial commercial JJ cord-023095-4dannjjm 5830 16 inactivated inactivate VBN cord-023095-4dannjjm 5830 17 vaccines vaccine NNS cord-023095-4dannjjm 5830 18 containing contain VBG cord-023095-4dannjjm 5830 19 different different JJ cord-023095-4dannjjm 5830 20 strains strain NNS cord-023095-4dannjjm 5830 21 of of IN cord-023095-4dannjjm 5830 22 A a NN cord-023095-4dannjjm 5830 23 / / SYM cord-023095-4dannjjm 5830 24 equine/2 equine/2 NN cord-023095-4dannjjm 5830 25 / / SYM cord-023095-4dannjjm 5830 26 influenza influenza NN cord-023095-4dannjjm 5830 27 virus virus NN cord-023095-4dannjjm 5830 28 's 's POS cord-023095-4dannjjm 5830 29 , , , cord-023095-4dannjjm 5830 30 including include VBG cord-023095-4dannjjm 5830 31 Innovator Innovator NNP cord-023095-4dannjjm 5830 32 TM TM NNP cord-023095-4dannjjm 5830 33 , , , cord-023095-4dannjjm 5830 34 containing contain VBG cord-023095-4dannjjm 5830 35 Kentucky/97 Kentucky/97 NNP cord-023095-4dannjjm 5831 1 ( ( -LRB- cord-023095-4dannjjm 5831 2 Pfizer Pfizer NNP cord-023095-4dannjjm 5831 3 Animal Animal NNP cord-023095-4dannjjm 5831 4 Health Health NNP cord-023095-4dannjjm 5831 5 , , , cord-023095-4dannjjm 5831 6 New New NNP cord-023095-4dannjjm 5831 7 York York NNP cord-023095-4dannjjm 5831 8 , , , cord-023095-4dannjjm 5831 9 NY NY NNP cord-023095-4dannjjm 5831 10 ) ) -RRB- cord-023095-4dannjjm 5831 11 , , , cord-023095-4dannjjm 5831 12 and and CC cord-023095-4dannjjm 5831 13 Calvenza Calvenza NNP cord-023095-4dannjjm 5831 14 , , , cord-023095-4dannjjm 5831 15 containing contain VBG cord-023095-4dannjjm 5831 16 a a DT cord-023095-4dannjjm 5831 17 combination combination NN cord-023095-4dannjjm 5831 18 of of IN cord-023095-4dannjjm 5831 19 Ohio/2003 Ohio/2003 NNP cord-023095-4dannjjm 5831 20 , , , cord-023095-4dannjjm 5831 21 Kentucky/ Kentucky/ NNP cord-023095-4dannjjm 5831 22 95 95 CD cord-023095-4dannjjm 5831 23 , , , cord-023095-4dannjjm 5831 24 and and CC cord-023095-4dannjjm 5831 25 Newmarket93 Newmarket93 NNP cord-023095-4dannjjm 5832 1 ( ( -LRB- cord-023095-4dannjjm 5832 2 Boehringer Boehringer NNP cord-023095-4dannjjm 5832 3 Ingelheim Ingelheim NNP cord-023095-4dannjjm 5832 4 Vetmedica Vetmedica NNP cord-023095-4dannjjm 5832 5 , , , cord-023095-4dannjjm 5832 6 St. St. NNP cord-023095-4dannjjm 5832 7 Joseph Joseph NNP cord-023095-4dannjjm 5832 8 , , , cord-023095-4dannjjm 5832 9 MS MS NNP cord-023095-4dannjjm 5832 10 ) ) -RRB- cord-023095-4dannjjm 5832 11 . . . cord-023095-4dannjjm 5833 1 The the DT cord-023095-4dannjjm 5833 2 challenge challenge NN cord-023095-4dannjjm 5833 3 virus virus NN cord-023095-4dannjjm 5833 4 strain strain NN cord-023095-4dannjjm 5833 5 was be VBD cord-023095-4dannjjm 5833 6 Colorado/07 colorado/07 CD cord-023095-4dannjjm 5833 7 , , , cord-023095-4dannjjm 5833 8 the the DT cord-023095-4dannjjm 5833 9 most most RBS cord-023095-4dannjjm 5833 10 contemporary contemporary JJ cord-023095-4dannjjm 5833 11 challenge challenge NN cord-023095-4dannjjm 5833 12 strain strain NN cord-023095-4dannjjm 5833 13 currently currently RB cord-023095-4dannjjm 5833 14 in in IN cord-023095-4dannjjm 5833 15 use use NN cord-023095-4dannjjm 5833 16 . . . cord-023095-4dannjjm 5834 1 The the DT cord-023095-4dannjjm 5834 2 study study NN cord-023095-4dannjjm 5834 3 design design NN cord-023095-4dannjjm 5834 4 was be VBD cord-023095-4dannjjm 5834 5 a a DT cord-023095-4dannjjm 5834 6 blinded blinded JJ cord-023095-4dannjjm 5834 7 , , , cord-023095-4dannjjm 5834 8 randomized randomized JJ cord-023095-4dannjjm 5834 9 challenge challenge NN cord-023095-4dannjjm 5834 10 trial trial NN cord-023095-4dannjjm 5834 11 . . . cord-023095-4dannjjm 5835 1 Three three CD cord-023095-4dannjjm 5835 2 groups group NNS cord-023095-4dannjjm 5835 3 of of IN cord-023095-4dannjjm 5835 4 10 10 CD cord-023095-4dannjjm 5835 5 yearling yearling NN cord-023095-4dannjjm 5835 6 ponies pony NNS cord-023095-4dannjjm 5835 7 , , , cord-023095-4dannjjm 5835 8 with with IN cord-023095-4dannjjm 5835 9 no no DT cord-023095-4dannjjm 5835 10 history history NN cord-023095-4dannjjm 5835 11 or or CC cord-023095-4dannjjm 5835 12 serological serological JJ cord-023095-4dannjjm 5835 13 evidence evidence NN cord-023095-4dannjjm 5835 14 of of IN cord-023095-4dannjjm 5835 15 EIV EIV NNP cord-023095-4dannjjm 5835 16 infection infection NN cord-023095-4dannjjm 5835 17 were be VBD cord-023095-4dannjjm 5835 18 established establish VBN cord-023095-4dannjjm 5835 19 . . . cord-023095-4dannjjm 5836 1 Each each DT cord-023095-4dannjjm 5836 2 group group NN cord-023095-4dannjjm 5836 3 received receive VBD cord-023095-4dannjjm 5836 4 one one CD cord-023095-4dannjjm 5836 5 of of IN cord-023095-4dannjjm 5836 6 three three CD cord-023095-4dannjjm 5836 7 treatments treatment NNS cord-023095-4dannjjm 5836 8 : : : cord-023095-4dannjjm 5836 9 vaccination vaccination NN cord-023095-4dannjjm 5836 10 with with IN cord-023095-4dannjjm 5836 11 Innovator Innovator NNP cord-023095-4dannjjm 5836 12 TM TM NNP cord-023095-4dannjjm 5836 13 ; ; : cord-023095-4dannjjm 5836 14 vaccination vaccination NN cord-023095-4dannjjm 5836 15 with with IN cord-023095-4dannjjm 5836 16 Calvenza Calvenza NNP cord-023095-4dannjjm 5836 17 TM TM NNP cord-023095-4dannjjm 5836 18 ; ; : cord-023095-4dannjjm 5836 19 or or CC cord-023095-4dannjjm 5836 20 injection injection NN cord-023095-4dannjjm 5836 21 with with IN cord-023095-4dannjjm 5836 22 a a DT cord-023095-4dannjjm 5836 23 saline saline NN cord-023095-4dannjjm 5836 24 placebo placebo NN cord-023095-4dannjjm 5836 25 . . . cord-023095-4dannjjm 5837 1 Each each DT cord-023095-4dannjjm 5837 2 treatment treatment NN cord-023095-4dannjjm 5837 3 was be VBD cord-023095-4dannjjm 5837 4 administered administer VBN cord-023095-4dannjjm 5837 5 3 3 CD cord-023095-4dannjjm 5837 6 times time NNS cord-023095-4dannjjm 5837 7 , , , cord-023095-4dannjjm 5837 8 at at IN cord-023095-4dannjjm 5837 9 intervals interval NNS cord-023095-4dannjjm 5837 10 of of IN cord-023095-4dannjjm 5837 11 1 1 CD cord-023095-4dannjjm 5837 12 month month NN cord-023095-4dannjjm 5837 13 between between IN cord-023095-4dannjjm 5837 14 the the DT cord-023095-4dannjjm 5837 15 first first JJ cord-023095-4dannjjm 5837 16 two two CD cord-023095-4dannjjm 5837 17 treatments treatment NNS cord-023095-4dannjjm 5837 18 , , , cord-023095-4dannjjm 5837 19 and and CC cord-023095-4dannjjm 5837 20 3 3 CD cord-023095-4dannjjm 5837 21 months month NNS cord-023095-4dannjjm 5837 22 between between IN cord-023095-4dannjjm 5837 23 the the DT cord-023095-4dannjjm 5837 24 second second JJ cord-023095-4dannjjm 5837 25 and and CC cord-023095-4dannjjm 5837 26 third third JJ cord-023095-4dannjjm 5837 27 treatments treatment NNS cord-023095-4dannjjm 5837 28 . . . cord-023095-4dannjjm 5838 1 All all DT cord-023095-4dannjjm 5838 2 ponies pony NNS cord-023095-4dannjjm 5838 3 were be VBD cord-023095-4dannjjm 5838 4 challenged challenge VBN cord-023095-4dannjjm 5838 5 by by IN cord-023095-4dannjjm 5838 6 nasal nasal NN cord-023095-4dannjjm 5838 7 nebulization nebulization NN cord-023095-4dannjjm 5838 8 of of IN cord-023095-4dannjjm 5838 9 5X10 5x10 CD cord-023095-4dannjjm 5838 10 7 7 CD cord-023095-4dannjjm 5838 11 EID EID NNP cord-023095-4dannjjm 5838 12 50 50 CD cord-023095-4dannjjm 5838 13 influenza influenza NN cord-023095-4dannjjm 5838 14 virus virus NN cord-023095-4dannjjm 5838 15 A a NN cord-023095-4dannjjm 5838 16 / / SYM cord-023095-4dannjjm 5838 17 eq/2 eq/2 NNP cord-023095-4dannjjm 5838 18 / / SYM cord-023095-4dannjjm 5838 19 Colorado/07 colorado/07 CD cord-023095-4dannjjm 5838 20 6 6 CD cord-023095-4dannjjm 5838 21 months month NNS cord-023095-4dannjjm 5838 22 after after IN cord-023095-4dannjjm 5838 23 the the DT cord-023095-4dannjjm 5838 24 third third JJ cord-023095-4dannjjm 5838 25 treatment treatment NN cord-023095-4dannjjm 5838 26 . . . cord-023095-4dannjjm 5839 1 Clinical clinical JJ cord-023095-4dannjjm 5839 2 signs sign NNS cord-023095-4dannjjm 5839 3 of of IN cord-023095-4dannjjm 5839 4 disease disease NN cord-023095-4dannjjm 5839 5 , , , cord-023095-4dannjjm 5839 6 including include VBG cord-023095-4dannjjm 5839 7 rectal rectal JJ cord-023095-4dannjjm 5839 8 temperature temperature NN cord-023095-4dannjjm 5839 9 , , , cord-023095-4dannjjm 5839 10 nasal nasal NN cord-023095-4dannjjm 5839 11 discharge discharge NN cord-023095-4dannjjm 5839 12 , , , cord-023095-4dannjjm 5839 13 anorexia anorexia NN cord-023095-4dannjjm 5839 14 , , , cord-023095-4dannjjm 5839 15 coughing coughing NN cord-023095-4dannjjm 5839 16 , , , cord-023095-4dannjjm 5839 17 and and CC cord-023095-4dannjjm 5839 18 depression depression NN cord-023095-4dannjjm 5839 19 , , , cord-023095-4dannjjm 5839 20 were be VBD cord-023095-4dannjjm 5839 21 recorded record VBN cord-023095-4dannjjm 5839 22 daily daily RB cord-023095-4dannjjm 5839 23 for for IN cord-023095-4dannjjm 5839 24 2 2 CD cord-023095-4dannjjm 5839 25 days day NNS cord-023095-4dannjjm 5839 26 prior prior RB cord-023095-4dannjjm 5839 27 to to IN cord-023095-4dannjjm 5839 28 challenge challenge NN cord-023095-4dannjjm 5839 29 infection infection NN cord-023095-4dannjjm 5839 30 , , , cord-023095-4dannjjm 5839 31 and and CC cord-023095-4dannjjm 5839 32 14 14 CD cord-023095-4dannjjm 5839 33 days day NNS cord-023095-4dannjjm 5839 34 post post JJ cord-023095-4dannjjm 5839 35 - - JJ cord-023095-4dannjjm 5839 36 challenge challenge NN cord-023095-4dannjjm 5839 37 . . . cord-023095-4dannjjm 5840 1 Nasal nasal NN cord-023095-4dannjjm 5840 2 shedding shedding NN cord-023095-4dannjjm 5840 3 of of IN cord-023095-4dannjjm 5840 4 EIV EIV NNP cord-023095-4dannjjm 5840 5 was be VBD cord-023095-4dannjjm 5840 6 measured measure VBN cord-023095-4dannjjm 5840 7 on on IN cord-023095-4dannjjm 5840 8 the the DT cord-023095-4dannjjm 5840 9 same same JJ cord-023095-4dannjjm 5840 10 days day NNS cord-023095-4dannjjm 5840 11 , , , cord-023095-4dannjjm 5840 12 using use VBG cord-023095-4dannjjm 5840 13 a a DT cord-023095-4dannjjm 5840 14 realtime realtime JJ cord-023095-4dannjjm 5840 15 PCR PCR NNP cord-023095-4dannjjm 5840 16 test test NN cord-023095-4dannjjm 5840 17 procedure procedure NN cord-023095-4dannjjm 5840 18 . . . cord-023095-4dannjjm 5841 1 EIV EIV NNP cord-023095-4dannjjm 5841 2 - - HYPH cord-023095-4dannjjm 5841 3 specific specific JJ cord-023095-4dannjjm 5841 4 antibody antibody NN cord-023095-4dannjjm 5841 5 responses response NNS cord-023095-4dannjjm 5841 6 were be VBD cord-023095-4dannjjm 5841 7 measured measure VBN cord-023095-4dannjjm 5841 8 by by IN cord-023095-4dannjjm 5841 9 ELISA ELISA NNP cord-023095-4dannjjm 5841 10 . . . cord-023095-4dannjjm 5842 1 Differences difference NNS cord-023095-4dannjjm 5842 2 between between IN cord-023095-4dannjjm 5842 3 groups group NNS cord-023095-4dannjjm 5842 4 were be VBD cord-023095-4dannjjm 5842 5 analyzed analyze VBN cord-023095-4dannjjm 5842 6 by by IN cord-023095-4dannjjm 5842 7 non non JJ cord-023095-4dannjjm 5842 8 - - JJ cord-023095-4dannjjm 5842 9 parametric parametric JJ cord-023095-4dannjjm 5842 10 repeated repeat VBN cord-023095-4dannjjm 5842 11 measures measure NNS cord-023095-4dannjjm 5842 12 ANOVA ANOVA NNP cord-023095-4dannjjm 5842 13 , , , cord-023095-4dannjjm 5842 14 and and CC cord-023095-4dannjjm 5842 15 differences difference NNS cord-023095-4dannjjm 5842 16 were be VBD cord-023095-4dannjjm 5842 17 declared declare VBN cord-023095-4dannjjm 5842 18 significant significant JJ cord-023095-4dannjjm 5842 19 when when WRB cord-023095-4dannjjm 5842 20 P p NN cord-023095-4dannjjm 5842 21 o o NN cord-023095-4dannjjm 5842 22 0.05 0.05 CD cord-023095-4dannjjm 5842 23 . . . cord-023095-4dannjjm 5843 1 All all DT cord-023095-4dannjjm 5843 2 control control NN cord-023095-4dannjjm 5843 3 group group NN cord-023095-4dannjjm 5843 4 ponies pony NNS cord-023095-4dannjjm 5843 5 demonstrated demonstrate VBD cord-023095-4dannjjm 5843 6 clinical clinical JJ cord-023095-4dannjjm 5843 7 signs sign NNS cord-023095-4dannjjm 5843 8 of of IN cord-023095-4dannjjm 5843 9 disease disease NN cord-023095-4dannjjm 5843 10 consistent consistent JJ cord-023095-4dannjjm 5843 11 with with IN cord-023095-4dannjjm 5843 12 EIV EIV NNP cord-023095-4dannjjm 5843 13 infection infection NN cord-023095-4dannjjm 5843 14 post post JJ cord-023095-4dannjjm 5843 15 - - JJ cord-023095-4dannjjm 5843 16 challenge challenge JJ cord-023095-4dannjjm 5843 17 infection infection NN cord-023095-4dannjjm 5843 18 , , , cord-023095-4dannjjm 5843 19 including include VBG cord-023095-4dannjjm 5843 20 pyrexia pyrexia NN cord-023095-4dannjjm 5843 21 , , , cord-023095-4dannjjm 5843 22 nasal nasal NN cord-023095-4dannjjm 5843 23 discharge discharge NN cord-023095-4dannjjm 5843 24 , , , cord-023095-4dannjjm 5843 25 inappetance inappetance NN cord-023095-4dannjjm 5843 26 and and CC cord-023095-4dannjjm 5843 27 partial partial JJ cord-023095-4dannjjm 5843 28 anorexia anorexia NN cord-023095-4dannjjm 5843 29 . . . cord-023095-4dannjjm 5844 1 These these DT cord-023095-4dannjjm 5844 2 signs sign NNS cord-023095-4dannjjm 5844 3 were be VBD cord-023095-4dannjjm 5844 4 significantly significantly RB cord-023095-4dannjjm 5844 5 lower low JJR cord-023095-4dannjjm 5844 6 in in IN cord-023095-4dannjjm 5844 7 both both DT cord-023095-4dannjjm 5844 8 vaccine vaccine NN cord-023095-4dannjjm 5844 9 groups group NNS cord-023095-4dannjjm 5844 10 ; ; : cord-023095-4dannjjm 5844 11 mean mean VB cord-023095-4dannjjm 5844 12 body body NN cord-023095-4dannjjm 5844 13 temperature temperature NN cord-023095-4dannjjm 5844 14 was be VBD cord-023095-4dannjjm 5844 15 elevated elevate VBN cord-023095-4dannjjm 5844 16 ( ( -LRB- cord-023095-4dannjjm 5844 17 4101.51F 4101.51f CD cord-023095-4dannjjm 5844 18 ) ) -RRB- cord-023095-4dannjjm 5844 19 for for IN cord-023095-4dannjjm 5844 20 8 8 CD cord-023095-4dannjjm 5844 21 days day NNS cord-023095-4dannjjm 5844 22 in in IN cord-023095-4dannjjm 5844 23 controls control NNS cord-023095-4dannjjm 5844 24 , , , cord-023095-4dannjjm 5844 25 but but CC cord-023095-4dannjjm 5844 26 only only RB cord-023095-4dannjjm 5844 27 2 2 CD cord-023095-4dannjjm 5844 28 days day NNS cord-023095-4dannjjm 5844 29 in in IN cord-023095-4dannjjm 5844 30 vaccine vaccine NN cord-023095-4dannjjm 5844 31 groups group NNS cord-023095-4dannjjm 5844 32 . . . cord-023095-4dannjjm 5845 1 Nasal nasal NN cord-023095-4dannjjm 5845 2 shedding shedding NN cord-023095-4dannjjm 5845 3 of of IN cord-023095-4dannjjm 5845 4 EIV EIV NNP cord-023095-4dannjjm 5845 5 was be VBD cord-023095-4dannjjm 5845 6 detected detect VBN cord-023095-4dannjjm 5845 7 in in IN cord-023095-4dannjjm 5845 8 all all DT cord-023095-4dannjjm 5845 9 ponies pony NNS cord-023095-4dannjjm 5845 10 in in IN cord-023095-4dannjjm 5845 11 all all DT cord-023095-4dannjjm 5845 12 groups group NNS cord-023095-4dannjjm 5845 13 : : : cord-023095-4dannjjm 5845 14 over over IN cord-023095-4dannjjm 5845 15 the the DT cord-023095-4dannjjm 5845 16 duration duration NN cord-023095-4dannjjm 5845 17 of of IN cord-023095-4dannjjm 5845 18 the the DT cord-023095-4dannjjm 5845 19 study study NN cord-023095-4dannjjm 5845 20 the the DT cord-023095-4dannjjm 5845 21 Calvenza Calvenza NNP cord-023095-4dannjjm 5845 22 group group NN cord-023095-4dannjjm 5845 23 shed shed VBD cord-023095-4dannjjm 5845 24 significantly significantly RB cord-023095-4dannjjm 5845 25 less less JJR cord-023095-4dannjjm 5845 26 virus virus NN cord-023095-4dannjjm 5845 27 than than IN cord-023095-4dannjjm 5845 28 Innovator Innovator NNP cord-023095-4dannjjm 5845 29 and and CC cord-023095-4dannjjm 5845 30 Control Control NNP cord-023095-4dannjjm 5845 31 . . . cord-023095-4dannjjm 5846 1 Over over IN cord-023095-4dannjjm 5846 2 time time NN cord-023095-4dannjjm 5846 3 antibody antibody NN cord-023095-4dannjjm 5846 4 titers titer NNS cord-023095-4dannjjm 5846 5 were be VBD cord-023095-4dannjjm 5846 6 significantly significantly RB cord-023095-4dannjjm 5846 7 higher high JJR cord-023095-4dannjjm 5846 8 in in IN cord-023095-4dannjjm 5846 9 the the DT cord-023095-4dannjjm 5846 10 Calvenza Calvenza NNP cord-023095-4dannjjm 5846 11 than than IN cord-023095-4dannjjm 5846 12 the the DT cord-023095-4dannjjm 5846 13 Innovator Innovator NNP cord-023095-4dannjjm 5846 14 group group NN cord-023095-4dannjjm 5846 15 , , , cord-023095-4dannjjm 5846 16 and and CC cord-023095-4dannjjm 5846 17 both both DT cord-023095-4dannjjm 5846 18 were be VBD cord-023095-4dannjjm 5846 19 significantly significantly RB cord-023095-4dannjjm 5846 20 greater great JJR cord-023095-4dannjjm 5846 21 than than IN cord-023095-4dannjjm 5846 22 controls control NNS cord-023095-4dannjjm 5846 23 . . . cord-023095-4dannjjm 5847 1 This this DT cord-023095-4dannjjm 5847 2 study study NN cord-023095-4dannjjm 5847 3 demonstrated demonstrate VBD cord-023095-4dannjjm 5847 4 that that IN cord-023095-4dannjjm 5847 5 both both DT cord-023095-4dannjjm 5847 6 current current JJ cord-023095-4dannjjm 5847 7 commercial commercial NN cord-023095-4dannjjm 5847 8 inactivated inactivate VBD cord-023095-4dannjjm 5847 9 EIV EIV NNP cord-023095-4dannjjm 5847 10 vaccines vaccine NNS cord-023095-4dannjjm 5847 11 have have VBP cord-023095-4dannjjm 5847 12 a a DT cord-023095-4dannjjm 5847 13 duration duration NN cord-023095-4dannjjm 5847 14 of of IN cord-023095-4dannjjm 5847 15 clinical clinical JJ cord-023095-4dannjjm 5847 16 protection protection NN cord-023095-4dannjjm 5847 17 of of IN cord-023095-4dannjjm 5847 18 at at RB cord-023095-4dannjjm 5847 19 least least RBS cord-023095-4dannjjm 5847 20 6 6 CD cord-023095-4dannjjm 5847 21 months month NNS cord-023095-4dannjjm 5847 22 after after IN cord-023095-4dannjjm 5847 23 a a DT cord-023095-4dannjjm 5847 24 highly highly RB cord-023095-4dannjjm 5847 25 pathogenic pathogenic JJ cord-023095-4dannjjm 5847 26 challenge challenge NN cord-023095-4dannjjm 5847 27 with with IN cord-023095-4dannjjm 5847 28 a a DT cord-023095-4dannjjm 5847 29 recent recent JJ cord-023095-4dannjjm 5847 30 EIV EIV NNP cord-023095-4dannjjm 5847 31 isolate isolate VBP cord-023095-4dannjjm 5847 32 . . . cord-023095-4dannjjm 5848 1 Both both DT cord-023095-4dannjjm 5848 2 antibody antibody NN cord-023095-4dannjjm 5848 3 responses response NNS cord-023095-4dannjjm 5848 4 and and CC cord-023095-4dannjjm 5848 5 virological virological JJ cord-023095-4dannjjm 5848 6 protection protection NN cord-023095-4dannjjm 5848 7 differed differ VBD cord-023095-4dannjjm 5848 8 between between IN cord-023095-4dannjjm 5848 9 the the DT cord-023095-4dannjjm 5848 10 vaccines vaccine NNS cord-023095-4dannjjm 5848 11 . . . cord-023095-4dannjjm 5849 1 Formulation formulation NN cord-023095-4dannjjm 5849 2 difference difference NN cord-023095-4dannjjm 5849 3 between between IN cord-023095-4dannjjm 5849 4 the the DT cord-023095-4dannjjm 5849 5 vaccines vaccine NNS cord-023095-4dannjjm 5849 6 , , , cord-023095-4dannjjm 5849 7 including include VBG cord-023095-4dannjjm 5849 8 the the DT cord-023095-4dannjjm 5849 9 EIV EIV NNP cord-023095-4dannjjm 5849 10 antigens antigen NNS cord-023095-4dannjjm 5849 11 employed employ VBN cord-023095-4dannjjm 5849 12 , , , cord-023095-4dannjjm 5849 13 may may MD cord-023095-4dannjjm 5849 14 have have VB cord-023095-4dannjjm 5849 15 contributed contribute VBN cord-023095-4dannjjm 5849 16 to to IN cord-023095-4dannjjm 5849 17 this this DT cord-023095-4dannjjm 5849 18 performance performance NN cord-023095-4dannjjm 5849 19 difference difference NN cord-023095-4dannjjm 5849 20 . . . cord-023095-4dannjjm 5850 1 Degenerative degenerative JJ cord-023095-4dannjjm 5850 2 myelopathy myelopathy NN cord-023095-4dannjjm 5850 3 ( ( -LRB- cord-023095-4dannjjm 5850 4 DM DM NNP cord-023095-4dannjjm 5850 5 ) ) -RRB- cord-023095-4dannjjm 5850 6 may may MD cord-023095-4dannjjm 5850 7 be be VB cord-023095-4dannjjm 5850 8 homologous homologous JJ cord-023095-4dannjjm 5850 9 to to IN cord-023095-4dannjjm 5850 10 a a DT cord-023095-4dannjjm 5850 11 form form NN cord-023095-4dannjjm 5850 12 of of IN cord-023095-4dannjjm 5850 13 amyotrophic amyotrophic JJ cord-023095-4dannjjm 5850 14 lateral lateral JJ cord-023095-4dannjjm 5850 15 sclerosis sclerosis NN cord-023095-4dannjjm 5850 16 in in IN cord-023095-4dannjjm 5850 17 humans human NNS cord-023095-4dannjjm 5850 18 which which WDT cord-023095-4dannjjm 5850 19 has have VBZ cord-023095-4dannjjm 5850 20 excitotoxic excitotoxic JJ cord-023095-4dannjjm 5850 21 and and CC cord-023095-4dannjjm 5850 22 immunologic immunologic JJ cord-023095-4dannjjm 5850 23 pathogeneses pathogenese NNS cord-023095-4dannjjm 5850 24 described describe VBN cord-023095-4dannjjm 5850 25 . . . cord-023095-4dannjjm 5851 1 The the DT cord-023095-4dannjjm 5851 2 aims aim NNS cord-023095-4dannjjm 5851 3 of of IN cord-023095-4dannjjm 5851 4 this this DT cord-023095-4dannjjm 5851 5 study study NN cord-023095-4dannjjm 5851 6 were be VBD cord-023095-4dannjjm 5851 7 to to TO cord-023095-4dannjjm 5851 8 determine determine VB cord-023095-4dannjjm 5851 9 ( ( -LRB- cord-023095-4dannjjm 5851 10 i i NN cord-023095-4dannjjm 5851 11 ) ) -RRB- cord-023095-4dannjjm 5851 12 presence presence NN cord-023095-4dannjjm 5851 13 or or CC cord-023095-4dannjjm 5851 14 absence absence NN cord-023095-4dannjjm 5851 15 of of IN cord-023095-4dannjjm 5851 16 abnormalities abnormality NNS cord-023095-4dannjjm 5851 17 in in IN cord-023095-4dannjjm 5851 18 concentrations concentration NNS cord-023095-4dannjjm 5851 19 of of IN cord-023095-4dannjjm 5851 20 CSF csf NN cord-023095-4dannjjm 5851 21 amino amino NN cord-023095-4dannjjm 5851 22 acid acid NN cord-023095-4dannjjm 5851 23 ( ( -LRB- cord-023095-4dannjjm 5851 24 AA AA NNP cord-023095-4dannjjm 5851 25 ) ) -RRB- cord-023095-4dannjjm 5851 26 neurotransmitters neurotransmitter NNS cord-023095-4dannjjm 5851 27 ( ( -LRB- cord-023095-4dannjjm 5851 28 glutamate glutamate NN cord-023095-4dannjjm 5851 29 , , , cord-023095-4dannjjm 5851 30 glycine glycine NN cord-023095-4dannjjm 5851 31 and and CC cord-023095-4dannjjm 5851 32 gÀaminobutyric gÀaminobutyric NNP cord-023095-4dannjjm 5851 33 acid acid NN cord-023095-4dannjjm 5851 34 ( ( -LRB- cord-023095-4dannjjm 5851 35 GABA GABA NNP cord-023095-4dannjjm 5851 36 ) ) -RRB- cord-023095-4dannjjm 5851 37 ) ) -RRB- cord-023095-4dannjjm 5851 38 and and CC cord-023095-4dannjjm 5851 39 cytokines cytokine NNS cord-023095-4dannjjm 5851 40 in in IN cord-023095-4dannjjm 5851 41 dogs dog NNS cord-023095-4dannjjm 5851 42 with with IN cord-023095-4dannjjm 5851 43 DM DM NNP cord-023095-4dannjjm 5851 44 and and CC cord-023095-4dannjjm 5851 45 if if IN cord-023095-4dannjjm 5851 46 present present JJ cord-023095-4dannjjm 5851 47 ( ( -LRB- cord-023095-4dannjjm 5851 48 ii ii NN cord-023095-4dannjjm 5851 49 ) ) -RRB- cord-023095-4dannjjm 5851 50 investigate investigate VBP cord-023095-4dannjjm 5851 51 associations association NNS cord-023095-4dannjjm 5851 52 with with IN cord-023095-4dannjjm 5851 53 disease disease NN cord-023095-4dannjjm 5851 54 severity severity NN cord-023095-4dannjjm 5851 55 . . . cord-023095-4dannjjm 5852 1 Twenty twenty CD cord-023095-4dannjjm 5852 2 - - HYPH cord-023095-4dannjjm 5852 3 two two CD cord-023095-4dannjjm 5852 4 dogs dog NNS cord-023095-4dannjjm 5852 5 histopathologically histopathologically RB cord-023095-4dannjjm 5852 6 confirmed confirm VBD cord-023095-4dannjjm 5852 7 for for IN cord-023095-4dannjjm 5852 8 DM DM NNP cord-023095-4dannjjm 5852 9 and and CC cord-023095-4dannjjm 5852 10 21 21 CD cord-023095-4dannjjm 5852 11 dogs dog NNS cord-023095-4dannjjm 5852 12 with with IN cord-023095-4dannjjm 5852 13 suspected suspect VBN cord-023095-4dannjjm 5852 14 DM dm NN cord-023095-4dannjjm 5852 15 based base VBN cord-023095-4dannjjm 5852 16 on on IN cord-023095-4dannjjm 5852 17 thorough thorough JJ cord-023095-4dannjjm 5852 18 diagnostic diagnostic JJ cord-023095-4dannjjm 5852 19 investigations investigation NNS cord-023095-4dannjjm 5852 20 and and CC cord-023095-4dannjjm 5852 21 42 42 CD cord-023095-4dannjjm 5852 22 clinically clinically RB cord-023095-4dannjjm 5852 23 normal normal JJ cord-023095-4dannjjm 5852 24 age age NN cord-023095-4dannjjm 5852 25 - - HYPH cord-023095-4dannjjm 5852 26 matched match VBN cord-023095-4dannjjm 5852 27 control control NN cord-023095-4dannjjm 5852 28 dogs dog NNS cord-023095-4dannjjm 5852 29 were be VBD cord-023095-4dannjjm 5852 30 included include VBN cord-023095-4dannjjm 5852 31 in in IN cord-023095-4dannjjm 5852 32 the the DT cord-023095-4dannjjm 5852 33 study study NN cord-023095-4dannjjm 5852 34 . . . cord-023095-4dannjjm 5853 1 The the DT cord-023095-4dannjjm 5853 2 neurological neurological JJ cord-023095-4dannjjm 5853 3 severity severity NN cord-023095-4dannjjm 5853 4 of of IN cord-023095-4dannjjm 5853 5 the the DT cord-023095-4dannjjm 5853 6 DM DM NNP cord-023095-4dannjjm 5853 7 dogs dog NNS cord-023095-4dannjjm 5853 8 was be VBD cord-023095-4dannjjm 5853 9 graded grade VBN cord-023095-4dannjjm 5853 10 ( ( -LRB- cord-023095-4dannjjm 5853 11 1 1 CD cord-023095-4dannjjm 5853 12 - - SYM cord-023095-4dannjjm 5853 13 4 4 CD cord-023095-4dannjjm 5853 14 ) ) -RRB- cord-023095-4dannjjm 5853 15 using use VBG cord-023095-4dannjjm 5853 16 an an DT cord-023095-4dannjjm 5853 17 established establish VBN cord-023095-4dannjjm 5853 18 scale scale NN cord-023095-4dannjjm 5853 19 . . . cord-023095-4dannjjm 5854 1 CSF CSF NNP cord-023095-4dannjjm 5854 2 was be VBD cord-023095-4dannjjm 5854 3 evaluated evaluate VBN cord-023095-4dannjjm 5854 4 for for IN cord-023095-4dannjjm 5854 5 presence presence NN cord-023095-4dannjjm 5854 6 of of IN cord-023095-4dannjjm 5854 7 glutamate glutamate NN cord-023095-4dannjjm 5854 8 , , , cord-023095-4dannjjm 5854 9 glycine glycine NN cord-023095-4dannjjm 5854 10 and and CC cord-023095-4dannjjm 5854 11 GABA GABA NNP cord-023095-4dannjjm 5854 12 by by IN cord-023095-4dannjjm 5854 13 high high JJ cord-023095-4dannjjm 5854 14 performance performance NN cord-023095-4dannjjm 5854 15 liquid liquid NN cord-023095-4dannjjm 5854 16 chromatography chromatography NN cord-023095-4dannjjm 5854 17 and and CC cord-023095-4dannjjm 5854 18 for for IN cord-023095-4dannjjm 5854 19 GM GM NNP cord-023095-4dannjjm 5854 20 - - HYPH cord-023095-4dannjjm 5854 21 CSF CSF NNP cord-023095-4dannjjm 5854 22 , , , cord-023095-4dannjjm 5854 23 IFN IFN NNP cord-023095-4dannjjm 5854 24 - - HYPH cord-023095-4dannjjm 5854 25 g g NNP cord-023095-4dannjjm 5854 26 , , , cord-023095-4dannjjm 5854 27 IL-2 IL-2 NNP cord-023095-4dannjjm 5854 28 , , , cord-023095-4dannjjm 5854 29 IL-4 IL-4 NNP cord-023095-4dannjjm 5854 30 , , , cord-023095-4dannjjm 5854 31 IL-6 IL-6 NNP cord-023095-4dannjjm 5854 32 , , , cord-023095-4dannjjm 5854 33 IL-7 IL-7 NNP cord-023095-4dannjjm 5854 34 , , , cord-023095-4dannjjm 5854 35 IL-8 IL-8 NNP cord-023095-4dannjjm 5854 36 , , , cord-023095-4dannjjm 5854 37 IL-10 IL-10 NNP cord-023095-4dannjjm 5854 38 , , , cord-023095-4dannjjm 5854 39 IL-15 IL-15 NNP cord-023095-4dannjjm 5854 40 , , , cord-023095-4dannjjm 5854 41 IL-18 IL-18 NNP cord-023095-4dannjjm 5854 42 , , , cord-023095-4dannjjm 5854 43 IP-10 IP-10 NNP cord-023095-4dannjjm 5854 44 , , , cord-023095-4dannjjm 5854 45 KC KC NNP cord-023095-4dannjjm 5854 46 ( ( -LRB- cord-023095-4dannjjm 5854 47 keratinocyte keratinocyte NNP cord-023095-4dannjjm 5854 48 chemoattractant chemoattractant NNP cord-023095-4dannjjm 5854 49 ) ) -RRB- cord-023095-4dannjjm 5854 50 , , , cord-023095-4dannjjm 5854 51 MCP-1 MCP-1 NNP cord-023095-4dannjjm 5855 1 ( ( -LRB- cord-023095-4dannjjm 5855 2 monocyte monocyte NNP cord-023095-4dannjjm 5855 3 chemotactic chemotactic VBD cord-023095-4dannjjm 5855 4 protein-1 protein-1 NNP cord-023095-4dannjjm 5855 5 ) ) -RRB- cord-023095-4dannjjm 5855 6 and and CC cord-023095-4dannjjm 5855 7 TNF TNF NNP cord-023095-4dannjjm 5855 8 - - , cord-023095-4dannjjm 5855 9 a a DT cord-023095-4dannjjm 5855 10 using use VBG cord-023095-4dannjjm 5855 11 a a DT cord-023095-4dannjjm 5855 12 commercially commercially RB cord-023095-4dannjjm 5855 13 available available JJ cord-023095-4dannjjm 5855 14 , , , cord-023095-4dannjjm 5855 15 canine canine JJ cord-023095-4dannjjm 5855 16 multiplex multiplex NN cord-023095-4dannjjm 5855 17 immunoassay immunoassay NN cord-023095-4dannjjm 5855 18 ( ( -LRB- cord-023095-4dannjjm 5855 19 Millipore Millipore NNP cord-023095-4dannjjm 5855 20 , , , cord-023095-4dannjjm 5855 21 Billerica Billerica NNP cord-023095-4dannjjm 5855 22 , , , cord-023095-4dannjjm 5855 23 MA MA NNP cord-023095-4dannjjm 5855 24 ) ) -RRB- cord-023095-4dannjjm 5855 25 . . . cord-023095-4dannjjm 5856 1 All all DT cord-023095-4dannjjm 5856 2 data data NN cord-023095-4dannjjm 5856 3 analyses analysis NNS cord-023095-4dannjjm 5856 4 were be VBD cord-023095-4dannjjm 5856 5 performed perform VBN cord-023095-4dannjjm 5856 6 using use VBG cord-023095-4dannjjm 5856 7 SAS SAS NNP cord-023095-4dannjjm 5856 8 V V NNP cord-023095-4dannjjm 5856 9 9.2 9.2 CD cord-023095-4dannjjm 5856 10 ( ( -LRB- cord-023095-4dannjjm 5856 11 Cary Cary NNP cord-023095-4dannjjm 5856 12 , , , cord-023095-4dannjjm 5856 13 NC NC NNP cord-023095-4dannjjm 5856 14 ) ) -RRB- cord-023095-4dannjjm 5856 15 . . . cord-023095-4dannjjm 5857 1 Analyte Analyte NNP cord-023095-4dannjjm 5857 2 levels level NNS cord-023095-4dannjjm 5857 3 were be VBD cord-023095-4dannjjm 5857 4 compared compare VBN cord-023095-4dannjjm 5857 5 between between IN cord-023095-4dannjjm 5857 6 DM DM NNP cord-023095-4dannjjm 5857 7 confirmed confirm VBD cord-023095-4dannjjm 5857 8 , , , cord-023095-4dannjjm 5857 9 DM DM NNP cord-023095-4dannjjm 5857 10 suspected suspect VBD cord-023095-4dannjjm 5857 11 and and CC cord-023095-4dannjjm 5857 12 control control NN cord-023095-4dannjjm 5857 13 dogs dog NNS cord-023095-4dannjjm 5857 14 by by IN cord-023095-4dannjjm 5857 15 an an DT cord-023095-4dannjjm 5857 16 analysis analysis NN cord-023095-4dannjjm 5857 17 of of IN cord-023095-4dannjjm 5857 18 variance variance NN cord-023095-4dannjjm 5857 19 ( ( -LRB- cord-023095-4dannjjm 5857 20 ANOVA ANOVA NNP cord-023095-4dannjjm 5857 21 ) ) -RRB- cord-023095-4dannjjm 5857 22 . . . cord-023095-4dannjjm 5858 1 Spearman Spearman NNP cord-023095-4dannjjm 5858 2 correlation correlation NN cord-023095-4dannjjm 5858 3 was be VBD cord-023095-4dannjjm 5858 4 used use VBN cord-023095-4dannjjm 5858 5 to to TO cord-023095-4dannjjm 5858 6 test test VB cord-023095-4dannjjm 5858 7 for for IN cord-023095-4dannjjm 5858 8 correlations correlation NNS cord-023095-4dannjjm 5858 9 of of IN cord-023095-4dannjjm 5858 10 analyte analyte JJ cord-023095-4dannjjm 5858 11 levels level NNS cord-023095-4dannjjm 5858 12 and and CC cord-023095-4dannjjm 5858 13 neurological neurological JJ cord-023095-4dannjjm 5858 14 grades grade NNS cord-023095-4dannjjm 5858 15 . . . cord-023095-4dannjjm 5859 1 All all DT cord-023095-4dannjjm 5859 2 hypothesis hypothesis NN cord-023095-4dannjjm 5859 3 tests test NNS cord-023095-4dannjjm 5859 4 were be VBD cord-023095-4dannjjm 5859 5 2-sided 2-side VBN cord-023095-4dannjjm 5859 6 with with IN cord-023095-4dannjjm 5859 7 a a DT cord-023095-4dannjjm 5859 8 5 5 CD cord-023095-4dannjjm 5859 9 0.05 0.05 CD cord-023095-4dannjjm 5859 10 . . . cord-023095-4dannjjm 5860 1 There there EX cord-023095-4dannjjm 5860 2 were be VBD cord-023095-4dannjjm 5860 3 no no DT cord-023095-4dannjjm 5860 4 significant significant JJ cord-023095-4dannjjm 5860 5 differences difference NNS cord-023095-4dannjjm 5860 6 between between IN cord-023095-4dannjjm 5860 7 individual individual JJ cord-023095-4dannjjm 5860 8 CSF CSF NNP cord-023095-4dannjjm 5860 9 analytes analyte NNS cord-023095-4dannjjm 5860 10 in in IN cord-023095-4dannjjm 5860 11 DM DM NNP cord-023095-4dannjjm 5860 12 confirmed confirm VBD cord-023095-4dannjjm 5860 13 and and CC cord-023095-4dannjjm 5860 14 DM DM NNP cord-023095-4dannjjm 5860 15 suspected suspect VBD cord-023095-4dannjjm 5860 16 dogs dog NNS cord-023095-4dannjjm 5860 17 . . . cord-023095-4dannjjm 5861 1 Glutamate glutamate NN cord-023095-4dannjjm 5861 2 levels level NNS cord-023095-4dannjjm 5861 3 were be VBD cord-023095-4dannjjm 5861 4 not not RB cord-023095-4dannjjm 5861 5 significantly significantly RB cord-023095-4dannjjm 5861 6 different different JJ cord-023095-4dannjjm 5861 7 between between IN cord-023095-4dannjjm 5861 8 DM dm NN cord-023095-4dannjjm 5861 9 affected affect VBN cord-023095-4dannjjm 5861 10 ( ( -LRB- cord-023095-4dannjjm 5861 11 mean mean VBP cord-023095-4dannjjm 5861 12 5 5 CD cord-023095-4dannjjm 5861 13 0.09 0.09 CD cord-023095-4dannjjm 5861 14 mg/ mg/ NN cord-023095-4dannjjm 5861 15 ml ml NN cord-023095-4dannjjm 5861 16 ; ; : cord-023095-4dannjjm 5862 1 range range NN cord-023095-4dannjjm 5862 2 5 5 CD cord-023095-4dannjjm 5862 3 0.01 0.01 CD cord-023095-4dannjjm 5862 4 - - HYPH cord-023095-4dannjjm 5862 5 0.29 0.29 CD cord-023095-4dannjjm 5862 6 ; ; : cord-023095-4dannjjm 5862 7 SD sd NN cord-023095-4dannjjm 5862 8 5 5 CD cord-023095-4dannjjm 5862 9 0.069 0.069 CD cord-023095-4dannjjm 5862 10 ) ) -RRB- cord-023095-4dannjjm 5862 11 and and CC cord-023095-4dannjjm 5862 12 control control NN cord-023095-4dannjjm 5862 13 dogs dog NNS cord-023095-4dannjjm 5862 14 ( ( -LRB- cord-023095-4dannjjm 5862 15 mean mean VB cord-023095-4dannjjm 5862 16 5 5 CD cord-023095-4dannjjm 5862 17 0.07 0.07 CD cord-023095-4dannjjm 5862 18 mg/ mg/ NN cord-023095-4dannjjm 5862 19 ml ml NN cord-023095-4dannjjm 5862 20 ; ; : cord-023095-4dannjjm 5862 21 range range NN cord-023095-4dannjjm 5862 22 5 5 CD cord-023095-4dannjjm 5862 23 0.01 0.01 CD cord-023095-4dannjjm 5862 24 - - HYPH cord-023095-4dannjjm 5862 25 0.29 0.29 CD cord-023095-4dannjjm 5862 26 ; ; : cord-023095-4dannjjm 5862 27 SD sd NN cord-023095-4dannjjm 5862 28 5 5 CD cord-023095-4dannjjm 5862 29 0.056 0.056 CD cord-023095-4dannjjm 5862 30 ) ) -RRB- cord-023095-4dannjjm 5862 31 . . . cord-023095-4dannjjm 5863 1 Control control NN cord-023095-4dannjjm 5863 2 dogs dog NNS cord-023095-4dannjjm 5863 3 ( ( -LRB- cord-023095-4dannjjm 5863 4 mean mean VB cord-023095-4dannjjm 5863 5 5 5 CD cord-023095-4dannjjm 5863 6 0.86 0.86 CD cord-023095-4dannjjm 5863 7 mg mg NNP cord-023095-4dannjjm 5863 8 / / SYM cord-023095-4dannjjm 5863 9 ml ml NN cord-023095-4dannjjm 5863 10 ; ; : cord-023095-4dannjjm 5863 11 range range VBP cord-023095-4dannjjm 5863 12 5 5 CD cord-023095-4dannjjm 5863 13 0.08 0.08 CD cord-023095-4dannjjm 5863 14 - - HYPH cord-023095-4dannjjm 5863 15 1.16 1.16 CD cord-023095-4dannjjm 5863 16 ; ; : cord-023095-4dannjjm 5863 17 SD SD NNP cord-023095-4dannjjm 5863 18 5 5 CD cord-023095-4dannjjm 5863 19 0.213 0.213 CD cord-023095-4dannjjm 5863 20 ) ) -RRB- cord-023095-4dannjjm 5863 21 had have VBD cord-023095-4dannjjm 5863 22 significantly significantly RB cord-023095-4dannjjm 5863 23 higher high JJR cord-023095-4dannjjm 5863 24 levels level NNS cord-023095-4dannjjm 5863 25 of of IN cord-023095-4dannjjm 5863 26 GABA GABA NNP cord-023095-4dannjjm 5863 27 ( ( -LRB- cord-023095-4dannjjm 5863 28 p p NN cord-023095-4dannjjm 5863 29 o o CD cord-023095-4dannjjm 5863 30 0.0001 0.0001 CD cord-023095-4dannjjm 5863 31 ) ) -RRB- cord-023095-4dannjjm 5863 32 than than IN cord-023095-4dannjjm 5863 33 DM DM NNP cord-023095-4dannjjm 5863 34 dogs dog NNS cord-023095-4dannjjm 5863 35 ( ( -LRB- cord-023095-4dannjjm 5863 36 mean mean VBP cord-023095-4dannjjm 5863 37 5 5 CD cord-023095-4dannjjm 5863 38 0.12 0.12 CD cord-023095-4dannjjm 5863 39 mg mg NNP cord-023095-4dannjjm 5863 40 / / SYM cord-023095-4dannjjm 5863 41 ml ml NN cord-023095-4dannjjm 5863 42 ; ; : cord-023095-4dannjjm 5863 43 range range NN cord-023095-4dannjjm 5863 44 5 5 CD cord-023095-4dannjjm 5863 45 0.07 0.07 CD cord-023095-4dannjjm 5863 46 - - HYPH cord-023095-4dannjjm 5863 47 0.79 0.79 CD cord-023095-4dannjjm 5863 48 ; ; : cord-023095-4dannjjm 5863 49 SD sd NN cord-023095-4dannjjm 5863 50 5 5 CD cord-023095-4dannjjm 5863 51 0.12 0.12 CD cord-023095-4dannjjm 5863 52 ) ) -RRB- cord-023095-4dannjjm 5863 53 . . . cord-023095-4dannjjm 5864 1 Control control NN cord-023095-4dannjjm 5864 2 dogs dog NNS cord-023095-4dannjjm 5864 3 ( ( -LRB- cord-023095-4dannjjm 5864 4 mean mean VB cord-023095-4dannjjm 5864 5 5 5 CD cord-023095-4dannjjm 5864 6 2.14 2.14 CD cord-023095-4dannjjm 5864 7 mg mg NNP cord-023095-4dannjjm 5864 8 / / SYM cord-023095-4dannjjm 5864 9 ml ml NN cord-023095-4dannjjm 5864 10 ; ; : cord-023095-4dannjjm 5864 11 range range NN cord-023095-4dannjjm 5864 12 5 5 CD cord-023095-4dannjjm 5864 13 0.01 0.01 CD cord-023095-4dannjjm 5864 14 - - HYPH cord-023095-4dannjjm 5864 15 3.83 3.83 CD cord-023095-4dannjjm 5864 16 ; ; : cord-023095-4dannjjm 5864 17 SD SD NNP cord-023095-4dannjjm 5864 18 5 5 CD cord-023095-4dannjjm 5864 19 0.76 0.76 CD cord-023095-4dannjjm 5864 20 ) ) -RRB- cord-023095-4dannjjm 5864 21 also also RB cord-023095-4dannjjm 5864 22 had have VBD cord-023095-4dannjjm 5864 23 significantly significantly RB cord-023095-4dannjjm 5864 24 higher high JJR cord-023095-4dannjjm 5864 25 glycine glycine NN cord-023095-4dannjjm 5864 26 concentrations concentration NNS cord-023095-4dannjjm 5864 27 ( ( -LRB- cord-023095-4dannjjm 5864 28 p p NN cord-023095-4dannjjm 5864 29 o o NN cord-023095-4dannjjm 5864 30 0.0001 0.0001 CD cord-023095-4dannjjm 5864 31 ) ) -RRB- cord-023095-4dannjjm 5864 32 than than IN cord-023095-4dannjjm 5864 33 DM DM NNP cord-023095-4dannjjm 5864 34 dogs dog NNS cord-023095-4dannjjm 5864 35 ( ( -LRB- cord-023095-4dannjjm 5864 36 mean mean VB cord-023095-4dannjjm 5865 1 5 5 CD cord-023095-4dannjjm 5865 2 0.45 0.45 CD cord-023095-4dannjjm 5865 3 mg mg NNP cord-023095-4dannjjm 5865 4 / / SYM cord-023095-4dannjjm 5865 5 ml ml NN cord-023095-4dannjjm 5865 6 ; ; : cord-023095-4dannjjm 5866 1 range range NN cord-023095-4dannjjm 5866 2 5 5 CD cord-023095-4dannjjm 5866 3 0.01 0.01 CD cord-023095-4dannjjm 5866 4 - - HYPH cord-023095-4dannjjm 5866 5 0.98 0.98 CD cord-023095-4dannjjm 5866 6 ; ; : cord-023095-4dannjjm 5866 7 SD sd NN cord-023095-4dannjjm 5866 8 5 5 CD cord-023095-4dannjjm 5866 9 0.24 0.24 CD cord-023095-4dannjjm 5866 10 ) ) -RRB- cord-023095-4dannjjm 5866 11 . . . cord-023095-4dannjjm 5867 1 DM dm NN cord-023095-4dannjjm 5867 2 - - HYPH cord-023095-4dannjjm 5867 3 affected affect VBN cord-023095-4dannjjm 5867 4 dogs dog NNS cord-023095-4dannjjm 5867 5 also also RB cord-023095-4dannjjm 5867 6 had have VBD cord-023095-4dannjjm 5867 7 significantly significantly RB cord-023095-4dannjjm 5867 8 higher high JJR cord-023095-4dannjjm 5867 9 levels level NNS cord-023095-4dannjjm 5867 10 of of IN cord-023095-4dannjjm 5867 11 IL-2 il-2 NN cord-023095-4dannjjm 5867 12 ( ( -LRB- cord-023095-4dannjjm 5867 13 p p NN cord-023095-4dannjjm 5867 14 5 5 CD cord-023095-4dannjjm 5867 15 0.03 0.03 CD cord-023095-4dannjjm 5867 16 ) ) -RRB- cord-023095-4dannjjm 5867 17 , , , cord-023095-4dannjjm 5867 18 KC KC NNP cord-023095-4dannjjm 5867 19 ( ( -LRB- cord-023095-4dannjjm 5867 20 p p NN cord-023095-4dannjjm 5867 21 o o CD cord-023095-4dannjjm 5867 22 0.0001 0.0001 CD cord-023095-4dannjjm 5867 23 ) ) -RRB- cord-023095-4dannjjm 5867 24 and and CC cord-023095-4dannjjm 5867 25 MCP-1 MCP-1 NNP cord-023095-4dannjjm 5868 1 ( ( -LRB- cord-023095-4dannjjm 5868 2 p p NN cord-023095-4dannjjm 5868 3 5 5 CD cord-023095-4dannjjm 5868 4 0.005 0.005 CD cord-023095-4dannjjm 5868 5 ) ) -RRB- cord-023095-4dannjjm 5868 6 than than IN cord-023095-4dannjjm 5868 7 control control NN cord-023095-4dannjjm 5868 8 dogs dog NNS cord-023095-4dannjjm 5868 9 . . . cord-023095-4dannjjm 5869 1 Neurotransmitter neurotransmitter NN cord-023095-4dannjjm 5869 2 levels level NNS cord-023095-4dannjjm 5869 3 were be VBD cord-023095-4dannjjm 5869 4 not not RB cord-023095-4dannjjm 5869 5 significantly significantly RB cord-023095-4dannjjm 5869 6 associated associate VBN cord-023095-4dannjjm 5869 7 with with IN cord-023095-4dannjjm 5869 8 neurological neurological JJ cord-023095-4dannjjm 5869 9 grade grade NN cord-023095-4dannjjm 5869 10 . . . cord-023095-4dannjjm 5870 1 KC KC NNP cord-023095-4dannjjm 5870 2 levels level NNS cord-023095-4dannjjm 5870 3 were be VBD cord-023095-4dannjjm 5870 4 significantly significantly RB cord-023095-4dannjjm 5870 5 higher high JJR cord-023095-4dannjjm 5870 6 in in IN cord-023095-4dannjjm 5870 7 the the DT cord-023095-4dannjjm 5870 8 least least JJS cord-023095-4dannjjm 5870 9 affected affected JJ cord-023095-4dannjjm 5870 10 dogs dog NNS cord-023095-4dannjjm 5870 11 ( ( -LRB- cord-023095-4dannjjm 5870 12 p p NN cord-023095-4dannjjm 5870 13 5 5 CD cord-023095-4dannjjm 5870 14 0.0015 0.0015 CD cord-023095-4dannjjm 5870 15 ) ) -RRB- cord-023095-4dannjjm 5870 16 . . . cord-023095-4dannjjm 5871 1 There there EX cord-023095-4dannjjm 5871 2 were be VBD cord-023095-4dannjjm 5871 3 no no DT cord-023095-4dannjjm 5871 4 associations association NNS cord-023095-4dannjjm 5871 5 with with IN cord-023095-4dannjjm 5871 6 disease disease NN cord-023095-4dannjjm 5871 7 severity severity NN cord-023095-4dannjjm 5871 8 and and CC cord-023095-4dannjjm 5871 9 analyte analyte NN cord-023095-4dannjjm 5871 10 concentrations concentration NNS cord-023095-4dannjjm 5871 11 . . . cord-023095-4dannjjm 5872 1 DM DM NNP cord-023095-4dannjjm 5872 2 affected affect VBD cord-023095-4dannjjm 5872 3 dogs dog NNS cord-023095-4dannjjm 5872 4 have have VBP cord-023095-4dannjjm 5872 5 an an DT cord-023095-4dannjjm 5872 6 imbalance imbalance NN cord-023095-4dannjjm 5872 7 of of IN cord-023095-4dannjjm 5872 8 CSF CSF NNP cord-023095-4dannjjm 5872 9 AA AA NNP cord-023095-4dannjjm 5872 10 concentrations concentration NNS cord-023095-4dannjjm 5872 11 creating create VBG cord-023095-4dannjjm 5872 12 a a DT cord-023095-4dannjjm 5872 13 relatively relatively RB cord-023095-4dannjjm 5872 14 excitotoxic excitotoxic JJ cord-023095-4dannjjm 5872 15 environment environment NN cord-023095-4dannjjm 5872 16 . . . cord-023095-4dannjjm 5873 1 Reports report NNS cord-023095-4dannjjm 5873 2 in in IN cord-023095-4dannjjm 5873 3 human human JJ cord-023095-4dannjjm 5873 4 ALS ALS NNP cord-023095-4dannjjm 5873 5 confirm confirm VBP cord-023095-4dannjjm 5873 6 an an DT cord-023095-4dannjjm 5873 7 imbalance imbalance NN cord-023095-4dannjjm 5873 8 between between IN cord-023095-4dannjjm 5873 9 CSF csf NN cord-023095-4dannjjm 5873 10 excitatory excitatory JJ cord-023095-4dannjjm 5873 11 and and CC cord-023095-4dannjjm 5873 12 inhibitory inhibitory JJ cord-023095-4dannjjm 5873 13 AAs aa NNS cord-023095-4dannjjm 5873 14 suggesting suggest VBG cord-023095-4dannjjm 5873 15 a a DT cord-023095-4dannjjm 5873 16 pathogenic pathogenic JJ cord-023095-4dannjjm 5873 17 role role NN cord-023095-4dannjjm 5873 18 for for IN cord-023095-4dannjjm 5873 19 excitotoxicity excitotoxicity NN cord-023095-4dannjjm 5873 20 in in IN cord-023095-4dannjjm 5873 21 ALS ALS NNP cord-023095-4dannjjm 5873 22 . . . cord-023095-4dannjjm 5874 1 It -PRON- PRP cord-023095-4dannjjm 5874 2 also also RB cord-023095-4dannjjm 5874 3 appears appear VBZ cord-023095-4dannjjm 5874 4 that that IN cord-023095-4dannjjm 5874 5 DM DM NNP cord-023095-4dannjjm 5874 6 affected affect VBN cord-023095-4dannjjm 5874 7 dogs dog NNS cord-023095-4dannjjm 5874 8 have have VBP cord-023095-4dannjjm 5874 9 increases increase NNS cord-023095-4dannjjm 5874 10 in in IN cord-023095-4dannjjm 5874 11 CSF CSF NNP cord-023095-4dannjjm 5874 12 cytokines cytokine NNS cord-023095-4dannjjm 5874 13 and and CC cord-023095-4dannjjm 5874 14 chemokines chemokine NNS cord-023095-4dannjjm 5874 15 suggestive suggestive JJ cord-023095-4dannjjm 5874 16 of of IN cord-023095-4dannjjm 5874 17 an an DT cord-023095-4dannjjm 5874 18 immunologic immunologic JJ cord-023095-4dannjjm 5874 19 component component NN cord-023095-4dannjjm 5874 20 to to IN cord-023095-4dannjjm 5874 21 the the DT cord-023095-4dannjjm 5874 22 pathogenesis pathogenesis NN cord-023095-4dannjjm 5874 23 as as IN cord-023095-4dannjjm 5874 24 is be VBZ cord-023095-4dannjjm 5874 25 similar similar JJ cord-023095-4dannjjm 5874 26 to to IN cord-023095-4dannjjm 5874 27 ALS ALS NNP cord-023095-4dannjjm 5874 28 . . . cord-023095-4dannjjm 5875 1 Further further JJ cord-023095-4dannjjm 5875 2 prospective prospective JJ cord-023095-4dannjjm 5875 3 analysis analysis NN cord-023095-4dannjjm 5875 4 of of IN cord-023095-4dannjjm 5875 5 DM DM NNP cord-023095-4dannjjm 5875 6 is be VBZ cord-023095-4dannjjm 5875 7 warranted warrant VBN cord-023095-4dannjjm 5875 8 to to TO cord-023095-4dannjjm 5875 9 evaluate evaluate VB cord-023095-4dannjjm 5875 10 the the DT cord-023095-4dannjjm 5875 11 role role NN cord-023095-4dannjjm 5875 12 of of IN cord-023095-4dannjjm 5875 13 treatment treatment NN cord-023095-4dannjjm 5875 14 on on IN cord-023095-4dannjjm 5875 15 CSF csf NN cord-023095-4dannjjm 5875 16 variables variable NNS cord-023095-4dannjjm 5875 17 . . . cord-023095-4dannjjm 5876 1 The the DT cord-023095-4dannjjm 5876 2 pathogenesis pathogenesis NN cord-023095-4dannjjm 5876 3 of of IN cord-023095-4dannjjm 5876 4 neuropathic neuropathic JJ cord-023095-4dannjjm 5876 5 pain pain NN cord-023095-4dannjjm 5876 6 ( ( -LRB- cord-023095-4dannjjm 5876 7 NP NP NNP cord-023095-4dannjjm 5876 8 ) ) -RRB- cord-023095-4dannjjm 5876 9 and and CC cord-023095-4dannjjm 5876 10 syringomyelia syringomyelia NNP cord-023095-4dannjjm 5876 11 ( ( -LRB- cord-023095-4dannjjm 5876 12 SM SM NNP cord-023095-4dannjjm 5876 13 ) ) -RRB- cord-023095-4dannjjm 5876 14 in in IN cord-023095-4dannjjm 5876 15 association association NN cord-023095-4dannjjm 5876 16 with with IN cord-023095-4dannjjm 5876 17 Chiari Chiari NNP cord-023095-4dannjjm 5876 18 - - HYPH cord-023095-4dannjjm 5876 19 like like JJ cord-023095-4dannjjm 5876 20 malformation malformation NN cord-023095-4dannjjm 5876 21 ( ( -LRB- cord-023095-4dannjjm 5876 22 CLM CLM NNP cord-023095-4dannjjm 5876 23 ) ) -RRB- cord-023095-4dannjjm 5876 24 in in IN cord-023095-4dannjjm 5876 25 dogs dog NNS cord-023095-4dannjjm 5876 26 has have VBZ cord-023095-4dannjjm 5876 27 focused focus VBN cord-023095-4dannjjm 5876 28 on on IN cord-023095-4dannjjm 5876 29 the the DT cord-023095-4dannjjm 5876 30 anatomical anatomical JJ cord-023095-4dannjjm 5876 31 anomalies anomaly NNS cord-023095-4dannjjm 5876 32 and and CC cord-023095-4dannjjm 5876 33 secondary secondary JJ cord-023095-4dannjjm 5876 34 cerebrospinal cerebrospinal NN cord-023095-4dannjjm 5876 35 fluid fluid NN cord-023095-4dannjjm 5876 36 ( ( -LRB- cord-023095-4dannjjm 5876 37 CSF CSF NNP cord-023095-4dannjjm 5876 38 ) ) -RRB- cord-023095-4dannjjm 5876 39 flow flow NN cord-023095-4dannjjm 5876 40 abnormalities abnormality NNS cord-023095-4dannjjm 5876 41 . . . cord-023095-4dannjjm 5877 1 Neuropathic neuropathic JJ cord-023095-4dannjjm 5877 2 pain pain NN cord-023095-4dannjjm 5877 3 in in IN cord-023095-4dannjjm 5877 4 humans human NNS cord-023095-4dannjjm 5877 5 has have VBZ cord-023095-4dannjjm 5877 6 been be VBN cord-023095-4dannjjm 5877 7 associated associate VBN cord-023095-4dannjjm 5877 8 with with IN cord-023095-4dannjjm 5877 9 abnormalities abnormality NNS cord-023095-4dannjjm 5877 10 of of IN cord-023095-4dannjjm 5877 11 neurotransmitters neurotransmitter NNS cord-023095-4dannjjm 5877 12 such such JJ cord-023095-4dannjjm 5877 13 as as IN cord-023095-4dannjjm 5877 14 glutamate glutamate NN cord-023095-4dannjjm 5877 15 and and CC cord-023095-4dannjjm 5877 16 serotonin serotonin NN cord-023095-4dannjjm 5877 17 as as RB cord-023095-4dannjjm 5877 18 well well RB cord-023095-4dannjjm 5877 19 as as IN cord-023095-4dannjjm 5877 20 immunologic immunologic JJ cord-023095-4dannjjm 5877 21 mechanisms mechanism NNS cord-023095-4dannjjm 5877 22 . . . cord-023095-4dannjjm 5878 1 The the DT cord-023095-4dannjjm 5878 2 aim aim NN cord-023095-4dannjjm 5878 3 of of IN cord-023095-4dannjjm 5878 4 this this DT cord-023095-4dannjjm 5878 5 study study NN cord-023095-4dannjjm 5878 6 was be VBD cord-023095-4dannjjm 5878 7 to to TO cord-023095-4dannjjm 5878 8 investigate investigate VB cord-023095-4dannjjm 5878 9 the the DT cord-023095-4dannjjm 5878 10 CSF CSF NNP cord-023095-4dannjjm 5878 11 neurotransmitter neurotransmitter NN cord-023095-4dannjjm 5878 12 and and CC cord-023095-4dannjjm 5878 13 cytokine cytokine NN cord-023095-4dannjjm 5878 14 levels level NNS cord-023095-4dannjjm 5878 15 in in IN cord-023095-4dannjjm 5878 16 Brussels Brussels NNP cord-023095-4dannjjm 5878 17 Griffon Griffon NNP cord-023095-4dannjjm 5878 18 dogs dog NNS cord-023095-4dannjjm 5878 19 ( ( -LRB- cord-023095-4dannjjm 5878 20 BGs BGs NNP cord-023095-4dannjjm 5878 21 ) ) -RRB- cord-023095-4dannjjm 5878 22 with with IN cord-023095-4dannjjm 5878 23 CLM CLM NNP cord-023095-4dannjjm 5878 24 , , , cord-023095-4dannjjm 5878 25 SM SM NNP cord-023095-4dannjjm 5878 26 and and CC cord-023095-4dannjjm 5878 27 NP NP NNP cord-023095-4dannjjm 5878 28 . . . cord-023095-4dannjjm 5879 1 As as IN cord-023095-4dannjjm 5879 2 part part NN cord-023095-4dannjjm 5879 3 of of IN cord-023095-4dannjjm 5879 4 an an DT cord-023095-4dannjjm 5879 5 MRI MRI NNP cord-023095-4dannjjm 5879 6 study study NN cord-023095-4dannjjm 5879 7 investigating investigate VBG cord-023095-4dannjjm 5879 8 the the DT cord-023095-4dannjjm 5879 9 prevalence prevalence NN cord-023095-4dannjjm 5879 10 of of IN cord-023095-4dannjjm 5879 11 SM SM NNP cord-023095-4dannjjm 5879 12 in in IN cord-023095-4dannjjm 5879 13 BGs bg NNS cord-023095-4dannjjm 5879 14 , , , cord-023095-4dannjjm 5879 15 atlanto atlanto NNP cord-023095-4dannjjm 5879 16 - - HYPH cord-023095-4dannjjm 5879 17 occipital occipital NNP cord-023095-4dannjjm 5879 18 CSF CSF NNP cord-023095-4dannjjm 5879 19 was be VBD cord-023095-4dannjjm 5879 20 acquired acquire VBN cord-023095-4dannjjm 5879 21 from from IN cord-023095-4dannjjm 5879 22 46 46 CD cord-023095-4dannjjm 5879 23 dogs dog NNS cord-023095-4dannjjm 5879 24 and and CC cord-023095-4dannjjm 5879 25 stored store VBN cord-023095-4dannjjm 5879 26 at at IN cord-023095-4dannjjm 5879 27 -80C -80C NNP cord-023095-4dannjjm 5879 28 until until IN cord-023095-4dannjjm 5879 29 analysis analysis NN cord-023095-4dannjjm 5879 30 . . . cord-023095-4dannjjm 5880 1 All all DT cord-023095-4dannjjm 5880 2 dogs dog NNS cord-023095-4dannjjm 5880 3 underwent undergo VBD cord-023095-4dannjjm 5880 4 a a DT cord-023095-4dannjjm 5880 5 neurologic neurologic JJ cord-023095-4dannjjm 5880 6 exam exam NN cord-023095-4dannjjm 5880 7 prior prior RB cord-023095-4dannjjm 5880 8 to to IN cord-023095-4dannjjm 5880 9 MRI MRI NNP cord-023095-4dannjjm 5880 10 ; ; : cord-023095-4dannjjm 5880 11 Osirix Osirix NNP cord-023095-4dannjjm 5880 12 s s NNP cord-023095-4dannjjm 5880 13 software software NN cord-023095-4dannjjm 5880 14 was be VBD cord-023095-4dannjjm 5880 15 used use VBN cord-023095-4dannjjm 5880 16 to to TO cord-023095-4dannjjm 5880 17 measure measure VB cord-023095-4dannjjm 5880 18 SM SM NNP cord-023095-4dannjjm 5880 19 and and CC cord-023095-4dannjjm 5880 20 the the DT cord-023095-4dannjjm 5880 21 presence presence NN cord-023095-4dannjjm 5880 22 of of IN cord-023095-4dannjjm 5880 23 cerebellar cerebellar JJ cord-023095-4dannjjm 5880 24 herniation herniation NN cord-023095-4dannjjm 5880 25 and and CC cord-023095-4dannjjm 5880 26 deviation deviation NN cord-023095-4dannjjm 5880 27 were be VBD cord-023095-4dannjjm 5880 28 recorded record VBN cord-023095-4dannjjm 5880 29 . . . cord-023095-4dannjjm 5881 1 Deproteinized Deproteinized NNP cord-023095-4dannjjm 5881 2 CSF CSF NNP cord-023095-4dannjjm 5881 3 samples sample NNS cord-023095-4dannjjm 5881 4 were be VBD cord-023095-4dannjjm 5881 5 analysed analyse VBN cord-023095-4dannjjm 5881 6 for for IN cord-023095-4dannjjm 5881 7 presence presence NN cord-023095-4dannjjm 5881 8 of of IN cord-023095-4dannjjm 5881 9 serotonin serotonin NN cord-023095-4dannjjm 5881 10 ( ( -LRB- cord-023095-4dannjjm 5881 11 ng ng NNP cord-023095-4dannjjm 5881 12 / / SYM cord-023095-4dannjjm 5881 13 ml ml NNP cord-023095-4dannjjm 5881 14 ) ) -RRB- cord-023095-4dannjjm 5881 15 , , , cord-023095-4dannjjm 5881 16 glutamate glutamate NN cord-023095-4dannjjm 5881 17 , , , cord-023095-4dannjjm 5881 18 glycine glycine NN cord-023095-4dannjjm 5881 19 and and CC cord-023095-4dannjjm 5881 20 GABA GABA NNP cord-023095-4dannjjm 5882 1 ( ( -LRB- cord-023095-4dannjjm 5882 2 mg mg NNP cord-023095-4dannjjm 5882 3 / / SYM cord-023095-4dannjjm 5882 4 ml ml NNP cord-023095-4dannjjm 5882 5 ) ) -RRB- cord-023095-4dannjjm 5882 6 by by IN cord-023095-4dannjjm 5882 7 high high JJ cord-023095-4dannjjm 5882 8 performance performance NN cord-023095-4dannjjm 5882 9 liquid liquid NN cord-023095-4dannjjm 5882 10 chromatography chromatography NN cord-023095-4dannjjm 5882 11 . . . cord-023095-4dannjjm 5883 1 All all DT cord-023095-4dannjjm 5883 2 CSF CSF NNP cord-023095-4dannjjm 5883 3 samples sample NNS cord-023095-4dannjjm 5883 4 were be VBD cord-023095-4dannjjm 5883 5 evaluated evaluate VBN cord-023095-4dannjjm 5883 6 simultaneously simultaneously RB cord-023095-4dannjjm 5883 7 for for IN cord-023095-4dannjjm 5883 8 GM GM NNP cord-023095-4dannjjm 5883 9 - - HYPH cord-023095-4dannjjm 5883 10 CSF CSF NNP cord-023095-4dannjjm 5883 11 , , , cord-023095-4dannjjm 5883 12 IFN IFN NNP cord-023095-4dannjjm 5883 13 - - HYPH cord-023095-4dannjjm 5883 14 g g NNP cord-023095-4dannjjm 5883 15 , , , cord-023095-4dannjjm 5883 16 IL-2 IL-2 NNP cord-023095-4dannjjm 5883 17 , , , cord-023095-4dannjjm 5883 18 IL-4 IL-4 NNP cord-023095-4dannjjm 5883 19 , , , cord-023095-4dannjjm 5883 20 IL-6 IL-6 NNP cord-023095-4dannjjm 5883 21 , , , cord-023095-4dannjjm 5883 22 IL-7 IL-7 NNP cord-023095-4dannjjm 5883 23 , , , cord-023095-4dannjjm 5883 24 IL-8 IL-8 NNP cord-023095-4dannjjm 5883 25 , , , cord-023095-4dannjjm 5883 26 IL-10 IL-10 NNP cord-023095-4dannjjm 5883 27 , , , cord-023095-4dannjjm 5883 28 IL-15 IL-15 NNP cord-023095-4dannjjm 5883 29 , , , cord-023095-4dannjjm 5883 30 IL-18 IL-18 NNP cord-023095-4dannjjm 5883 31 , , , cord-023095-4dannjjm 5883 32 IP-10 IP-10 NNP cord-023095-4dannjjm 5883 33 , , , cord-023095-4dannjjm 5883 34 KC KC NNP cord-023095-4dannjjm 5883 35 , , , cord-023095-4dannjjm 5883 36 MCP-1 MCP-1 NNP cord-023095-4dannjjm 5883 37 and and CC cord-023095-4dannjjm 5883 38 TNF TNF NNP cord-023095-4dannjjm 5883 39 - - HYPH cord-023095-4dannjjm 5883 40 a a NN cord-023095-4dannjjm 5883 41 . . . cord-023095-4dannjjm 5884 1 A a DT cord-023095-4dannjjm 5884 2 commercially commercially RB cord-023095-4dannjjm 5884 3 available available JJ cord-023095-4dannjjm 5884 4 , , , cord-023095-4dannjjm 5884 5 canine canine JJ cord-023095-4dannjjm 5884 6 multiplex multiplex NN cord-023095-4dannjjm 5884 7 immunoassay immunoassay NN cord-023095-4dannjjm 5884 8 ( ( -LRB- cord-023095-4dannjjm 5884 9 Millipore Millipore NNP cord-023095-4dannjjm 5884 10 , , , cord-023095-4dannjjm 5884 11 Billerica Billerica NNP cord-023095-4dannjjm 5884 12 , , , cord-023095-4dannjjm 5884 13 MA MA NNP cord-023095-4dannjjm 5884 14 ) ) -RRB- cord-023095-4dannjjm 5884 15 was be VBD cord-023095-4dannjjm 5884 16 used use VBN cord-023095-4dannjjm 5884 17 for for IN cord-023095-4dannjjm 5884 18 the the DT cord-023095-4dannjjm 5884 19 cytokine cytokine NN cord-023095-4dannjjm 5884 20 analysis analysis NN cord-023095-4dannjjm 5884 21 ( ( -LRB- cord-023095-4dannjjm 5884 22 pg pg NNP cord-023095-4dannjjm 5884 23 / / SYM cord-023095-4dannjjm 5884 24 ml ml NNP cord-023095-4dannjjm 5884 25 ) ) -RRB- cord-023095-4dannjjm 5884 26 . . . cord-023095-4dannjjm 5885 1 Student student NN cord-023095-4dannjjm 5885 2 's 's POS cord-023095-4dannjjm 5885 3 t t NN cord-023095-4dannjjm 5885 4 - - HYPH cord-023095-4dannjjm 5885 5 tests test NNS cord-023095-4dannjjm 5885 6 were be VBD cord-023095-4dannjjm 5885 7 used use VBN cord-023095-4dannjjm 5885 8 to to TO cord-023095-4dannjjm 5885 9 compare compare VB cord-023095-4dannjjm 5885 10 the the DT cord-023095-4dannjjm 5885 11 means mean NNS cord-023095-4dannjjm 5885 12 of of IN cord-023095-4dannjjm 5885 13 neurotransmitter neurotransmitter NN cord-023095-4dannjjm 5885 14 and and CC cord-023095-4dannjjm 5885 15 cytokine cytokine NN cord-023095-4dannjjm 5885 16 values value NNS cord-023095-4dannjjm 5885 17 between between IN cord-023095-4dannjjm 5885 18 groups group NNS cord-023095-4dannjjm 5885 19 with with IN cord-023095-4dannjjm 5885 20 and and CC cord-023095-4dannjjm 5885 21 without without IN cord-023095-4dannjjm 5885 22 skull skull NN cord-023095-4dannjjm 5885 23 abnormalities abnormality NNS cord-023095-4dannjjm 5885 24 or or CC cord-023095-4dannjjm 5885 25 spinal spinal JJ cord-023095-4dannjjm 5885 26 pain pain NN cord-023095-4dannjjm 5885 27 . . . cord-023095-4dannjjm 5886 1 Simple Simple NNP cord-023095-4dannjjm 5886 2 Pearson Pearson NNP cord-023095-4dannjjm 5886 3 's 's POS cord-023095-4dannjjm 5886 4 correlation correlation NN cord-023095-4dannjjm 5886 5 was be VBD cord-023095-4dannjjm 5886 6 used use VBN cord-023095-4dannjjm 5886 7 to to TO cord-023095-4dannjjm 5886 8 test test VB cord-023095-4dannjjm 5886 9 for for IN cord-023095-4dannjjm 5886 10 correlations correlation NNS cord-023095-4dannjjm 5886 11 of of IN cord-023095-4dannjjm 5886 12 neurotransmitter neurotransmitter NN cord-023095-4dannjjm 5886 13 and and CC cord-023095-4dannjjm 5886 14 cytokine cytokine NN cord-023095-4dannjjm 5886 15 values value NNS cord-023095-4dannjjm 5886 16 with with IN cord-023095-4dannjjm 5886 17 syrinx syrinx NNP cord-023095-4dannjjm 5886 18 dimensions dimension NNS cord-023095-4dannjjm 5886 19 and and CC cord-023095-4dannjjm 5886 20 correlations correlation NNS cord-023095-4dannjjm 5886 21 of of IN cord-023095-4dannjjm 5886 22 neurotransmitter neurotransmitter NN cord-023095-4dannjjm 5886 23 with with IN cord-023095-4dannjjm 5886 24 cytokine cytokine JJ cord-023095-4dannjjm 5886 25 values value NNS cord-023095-4dannjjm 5886 26 . . . cord-023095-4dannjjm 5887 1 All all DT cord-023095-4dannjjm 5887 2 hypothesis hypothesis NN cord-023095-4dannjjm 5887 3 tests test NNS cord-023095-4dannjjm 5887 4 were be VBD cord-023095-4dannjjm 5887 5 2-sided 2-sided JJ cord-023095-4dannjjm 5887 6 and and CC cord-023095-4dannjjm 5887 7 the the DT cord-023095-4dannjjm 5887 8 significance significance NN cord-023095-4dannjjm 5887 9 level level NN cord-023095-4dannjjm 5887 10 was be VBD cord-023095-4dannjjm 5887 11 a a DT cord-023095-4dannjjm 5887 12 5 5 CD cord-023095-4dannjjm 5887 13 0.05 0.05 CD cord-023095-4dannjjm 5887 14 . . . cord-023095-4dannjjm 5888 1 NP NP NNP cord-023095-4dannjjm 5888 2 was be VBD cord-023095-4dannjjm 5888 3 detected detect VBN cord-023095-4dannjjm 5888 4 in in IN cord-023095-4dannjjm 5888 5 8 8 CD cord-023095-4dannjjm 5888 6 dogs dog NNS cord-023095-4dannjjm 5888 7 ( ( -LRB- cord-023095-4dannjjm 5888 8 17 17 CD cord-023095-4dannjjm 5888 9 % % NN cord-023095-4dannjjm 5888 10 ) ) -RRB- cord-023095-4dannjjm 5888 11 ; ; : cord-023095-4dannjjm 5888 12 SM SM NNP cord-023095-4dannjjm 5888 13 was be VBD cord-023095-4dannjjm 5888 14 present present JJ cord-023095-4dannjjm 5888 15 24 24 CD cord-023095-4dannjjm 5888 16 dogs dog NNS cord-023095-4dannjjm 5888 17 ( ( -LRB- cord-023095-4dannjjm 5888 18 52 52 CD cord-023095-4dannjjm 5888 19 % % NN cord-023095-4dannjjm 5888 20 ) ) -RRB- cord-023095-4dannjjm 5888 21 ; ; : cord-023095-4dannjjm 5888 22 and and CC cord-023095-4dannjjm 5888 23 CM CM NNP cord-023095-4dannjjm 5888 24 was be VBD cord-023095-4dannjjm 5888 25 detected detect VBN cord-023095-4dannjjm 5888 26 in in IN cord-023095-4dannjjm 5888 27 24 24 CD cord-023095-4dannjjm 5888 28 dogs dog NNS cord-023095-4dannjjm 5888 29 ( ( -LRB- cord-023095-4dannjjm 5888 30 52 52 CD cord-023095-4dannjjm 5888 31 % % NN cord-023095-4dannjjm 5888 32 ) ) -RRB- cord-023095-4dannjjm 5888 33 . . . cord-023095-4dannjjm 5889 1 IFN IFN NNP cord-023095-4dannjjm 5889 2 - - HYPH cord-023095-4dannjjm 5889 3 g g NN cord-023095-4dannjjm 5889 4 levels level NNS cord-023095-4dannjjm 5889 5 were be VBD cord-023095-4dannjjm 5889 6 significantly significantly RB cord-023095-4dannjjm 5889 7 lower low JJR cord-023095-4dannjjm 5889 8 in in IN cord-023095-4dannjjm 5889 9 dogs dog NNS cord-023095-4dannjjm 5889 10 with with IN cord-023095-4dannjjm 5889 11 NP NP NNP cord-023095-4dannjjm 5889 12 than than IN cord-023095-4dannjjm 5889 13 without without IN cord-023095-4dannjjm 5889 14 ( ( -LRB- cord-023095-4dannjjm 5889 15 p p NN cord-023095-4dannjjm 5889 16 5 5 CD cord-023095-4dannjjm 5889 17 0.036 0.036 CD cord-023095-4dannjjm 5889 18 ) ) -RRB- cord-023095-4dannjjm 5889 19 . . . cord-023095-4dannjjm 5890 1 There there EX cord-023095-4dannjjm 5890 2 were be VBD cord-023095-4dannjjm 5890 3 significant significant JJ cord-023095-4dannjjm 5890 4 positive positive JJ cord-023095-4dannjjm 5890 5 correlations correlation NNS cord-023095-4dannjjm 5890 6 between between IN cord-023095-4dannjjm 5890 7 syrinx syrinx NNP cord-023095-4dannjjm 5890 8 size size NN cord-023095-4dannjjm 5890 9 and and CC cord-023095-4dannjjm 5890 10 IL-8 IL-8 NNP cord-023095-4dannjjm 5890 11 ( ( -LRB- cord-023095-4dannjjm 5890 12 p p NN cord-023095-4dannjjm 5890 13 5 5 CD cord-023095-4dannjjm 5890 14 0.017 0.017 CD cord-023095-4dannjjm 5890 15 ) ) -RRB- cord-023095-4dannjjm 5890 16 , , , cord-023095-4dannjjm 5890 17 KC KC NNP cord-023095-4dannjjm 5890 18 ( ( -LRB- cord-023095-4dannjjm 5890 19 p p NN cord-023095-4dannjjm 5890 20 5 5 CD cord-023095-4dannjjm 5890 21 0.025 0.025 CD cord-023095-4dannjjm 5890 22 ) ) -RRB- cord-023095-4dannjjm 5890 23 and and CC cord-023095-4dannjjm 5890 24 MCP-1 MCP-1 NNP cord-023095-4dannjjm 5891 1 ( ( -LRB- cord-023095-4dannjjm 5891 2 p p NN cord-023095-4dannjjm 5891 3 5 5 CD cord-023095-4dannjjm 5891 4 0.003 0.003 CD cord-023095-4dannjjm 5891 5 ) ) -RRB- cord-023095-4dannjjm 5891 6 . . . cord-023095-4dannjjm 5892 1 There there EX cord-023095-4dannjjm 5892 2 were be VBD cord-023095-4dannjjm 5892 3 significant significant JJ cord-023095-4dannjjm 5892 4 negative negative JJ cord-023095-4dannjjm 5892 5 correlations correlation NNS cord-023095-4dannjjm 5892 6 between between IN cord-023095-4dannjjm 5892 7 IFN IFN NNP cord-023095-4dannjjm 5892 8 - - HYPH cord-023095-4dannjjm 5892 9 g g NNP cord-023095-4dannjjm 5892 10 and and CC cord-023095-4dannjjm 5892 11 syrinx syrinx NNP cord-023095-4dannjjm 5892 12 height height NNP cord-023095-4dannjjm 5892 13 ( ( -LRB- cord-023095-4dannjjm 5892 14 p p NN cord-023095-4dannjjm 5892 15 5 5 CD cord-023095-4dannjjm 5892 16 0.025 0.025 CD cord-023095-4dannjjm 5892 17 ) ) -RRB- cord-023095-4dannjjm 5892 18 and and CC cord-023095-4dannjjm 5892 19 extent extent NN cord-023095-4dannjjm 5892 20 ( ( -LRB- cord-023095-4dannjjm 5892 21 p p NN cord-023095-4dannjjm 5892 22 5 5 CD cord-023095-4dannjjm 5892 23 0.042 0.042 CD cord-023095-4dannjjm 5892 24 ) ) -RRB- cord-023095-4dannjjm 5892 25 . . . cord-023095-4dannjjm 5893 1 There there EX cord-023095-4dannjjm 5893 2 was be VBD cord-023095-4dannjjm 5893 3 a a DT cord-023095-4dannjjm 5893 4 significant significant JJ cord-023095-4dannjjm 5893 5 negative negative JJ cord-023095-4dannjjm 5893 6 correlation correlation NN cord-023095-4dannjjm 5893 7 between between IN cord-023095-4dannjjm 5893 8 IL-2 IL-2 NNP cord-023095-4dannjjm 5893 9 and and CC cord-023095-4dannjjm 5893 10 syrinx syrinx NNP cord-023095-4dannjjm 5893 11 height height NNP cord-023095-4dannjjm 5894 1 ( ( -LRB- cord-023095-4dannjjm 5894 2 p p NN cord-023095-4dannjjm 5894 3 5 5 CD cord-023095-4dannjjm 5894 4 0.042 0.042 CD cord-023095-4dannjjm 5894 5 ) ) -RRB- cord-023095-4dannjjm 5894 6 . . . cord-023095-4dannjjm 5895 1 Neurotransmitter neurotransmitter NN cord-023095-4dannjjm 5895 2 levels level NNS cord-023095-4dannjjm 5895 3 were be VBD cord-023095-4dannjjm 5895 4 not not RB cord-023095-4dannjjm 5895 5 associated associate VBN cord-023095-4dannjjm 5895 6 with with IN cord-023095-4dannjjm 5895 7 skull skull NN cord-023095-4dannjjm 5895 8 abnormalities abnormality NNS cord-023095-4dannjjm 5895 9 or or CC cord-023095-4dannjjm 5895 10 spinal spinal JJ cord-023095-4dannjjm 5895 11 pain pain NN cord-023095-4dannjjm 5895 12 , , , cord-023095-4dannjjm 5895 13 but but CC cord-023095-4dannjjm 5895 14 there there EX cord-023095-4dannjjm 5895 15 was be VBD cord-023095-4dannjjm 5895 16 a a DT cord-023095-4dannjjm 5895 17 positive positive JJ cord-023095-4dannjjm 5895 18 correlation correlation NN cord-023095-4dannjjm 5895 19 of of IN cord-023095-4dannjjm 5895 20 glycine glycine NN cord-023095-4dannjjm 5895 21 with with IN cord-023095-4dannjjm 5895 22 IL-2 IL-2 NNP cord-023095-4dannjjm 5895 23 ( ( -LRB- cord-023095-4dannjjm 5895 24 p p NN cord-023095-4dannjjm 5895 25 5 5 CD cord-023095-4dannjjm 5895 26 0.004 0.004 CD cord-023095-4dannjjm 5895 27 ) ) -RRB- cord-023095-4dannjjm 5895 28 and and CC cord-023095-4dannjjm 5895 29 MCP-1 MCP-1 NNP cord-023095-4dannjjm 5895 30 with with IN cord-023095-4dannjjm 5895 31 glutamate glutamate NN cord-023095-4dannjjm 5895 32 ( ( -LRB- cord-023095-4dannjjm 5895 33 p p NN cord-023095-4dannjjm 5895 34 5 5 CD cord-023095-4dannjjm 5895 35 0.0147 0.0147 CD cord-023095-4dannjjm 5895 36 ) ) -RRB- cord-023095-4dannjjm 5895 37 and and CC cord-023095-4dannjjm 5895 38 serotonin serotonin NN cord-023095-4dannjjm 5895 39 ( ( -LRB- cord-023095-4dannjjm 5895 40 p p NN cord-023095-4dannjjm 5895 41 5 5 CD cord-023095-4dannjjm 5895 42 0.0059 0.0059 CD cord-023095-4dannjjm 5895 43 ) ) -RRB- cord-023095-4dannjjm 5895 44 . . . cord-023095-4dannjjm 5896 1 The the DT cord-023095-4dannjjm 5896 2 size size NN cord-023095-4dannjjm 5896 3 of of IN cord-023095-4dannjjm 5896 4 the the DT cord-023095-4dannjjm 5896 5 syrinx syrinx NNP cord-023095-4dannjjm 5896 6 in in IN cord-023095-4dannjjm 5896 7 BGs bg NNS cord-023095-4dannjjm 5896 8 with with IN cord-023095-4dannjjm 5896 9 SM SM NNP cord-023095-4dannjjm 5896 10 is be VBZ cord-023095-4dannjjm 5896 11 associated associate VBN cord-023095-4dannjjm 5896 12 with with IN cord-023095-4dannjjm 5896 13 several several JJ cord-023095-4dannjjm 5896 14 cytokine cytokine JJ cord-023095-4dannjjm 5896 15 elevations elevation NNS cord-023095-4dannjjm 5896 16 but but CC cord-023095-4dannjjm 5896 17 only only RB cord-023095-4dannjjm 5896 18 a a DT cord-023095-4dannjjm 5896 19 decrease decrease NN cord-023095-4dannjjm 5896 20 of of IN cord-023095-4dannjjm 5896 21 IFN IFN NNP cord-023095-4dannjjm 5896 22 - - HYPH cord-023095-4dannjjm 5896 23 g g NNP cord-023095-4dannjjm 5896 24 was be VBD cord-023095-4dannjjm 5896 25 associated associate VBN cord-023095-4dannjjm 5896 26 with with IN cord-023095-4dannjjm 5896 27 NP NP NNP cord-023095-4dannjjm 5896 28 . . . cord-023095-4dannjjm 5897 1 Based base VBN cord-023095-4dannjjm 5897 2 on on IN cord-023095-4dannjjm 5897 3 this this DT cord-023095-4dannjjm 5897 4 study study NN cord-023095-4dannjjm 5897 5 it -PRON- PRP cord-023095-4dannjjm 5897 6 does do VBZ cord-023095-4dannjjm 5897 7 not not RB cord-023095-4dannjjm 5897 8 appear appear VB cord-023095-4dannjjm 5897 9 that that IN cord-023095-4dannjjm 5897 10 excitotoxicity excitotoxicity NN cord-023095-4dannjjm 5897 11 plays play VBZ cord-023095-4dannjjm 5897 12 a a DT cord-023095-4dannjjm 5897 13 role role NN cord-023095-4dannjjm 5897 14 in in IN cord-023095-4dannjjm 5897 15 either either CC cord-023095-4dannjjm 5897 16 SM SM NNP cord-023095-4dannjjm 5897 17 development development NN cord-023095-4dannjjm 5897 18 or or CC cord-023095-4dannjjm 5897 19 NP NP NNP cord-023095-4dannjjm 5897 20 . . . cord-023095-4dannjjm 5898 1 Further further JJ cord-023095-4dannjjm 5898 2 work work NN cord-023095-4dannjjm 5898 3 is be VBZ cord-023095-4dannjjm 5898 4 justified justify VBN cord-023095-4dannjjm 5898 5 on on IN cord-023095-4dannjjm 5898 6 the the DT cord-023095-4dannjjm 5898 7 role role NN cord-023095-4dannjjm 5898 8 of of IN cord-023095-4dannjjm 5898 9 the the DT cord-023095-4dannjjm 5898 10 immune immune JJ cord-023095-4dannjjm 5898 11 system system NN cord-023095-4dannjjm 5898 12 in in IN cord-023095-4dannjjm 5898 13 CM CM NNP cord-023095-4dannjjm 5898 14 , , , cord-023095-4dannjjm 5898 15 SM SM NNP cord-023095-4dannjjm 5898 16 and and CC cord-023095-4dannjjm 5898 17 NP NP NNP cord-023095-4dannjjm 5898 18 . . . cord-023095-4dannjjm 5899 1 Current current JJ cord-023095-4dannjjm 5899 2 knowledge knowledge NN cord-023095-4dannjjm 5899 3 about about IN cord-023095-4dannjjm 5899 4 the the DT cord-023095-4dannjjm 5899 5 conservative conservative JJ cord-023095-4dannjjm 5899 6 management management NN cord-023095-4dannjjm 5899 7 of of IN cord-023095-4dannjjm 5899 8 disk disk NN cord-023095-4dannjjm 5899 9 associated associate VBD cord-023095-4dannjjm 5899 10 cervical cervical JJ cord-023095-4dannjjm 5899 11 spondylomyelopathy spondylomyelopathy NN cord-023095-4dannjjm 5899 12 ( ( -LRB- cord-023095-4dannjjm 5899 13 DA DA NNP cord-023095-4dannjjm 5899 14 - - HYPH cord-023095-4dannjjm 5899 15 CSM CSM NNP cord-023095-4dannjjm 5899 16 ) ) -RRB- cord-023095-4dannjjm 5899 17 is be VBZ cord-023095-4dannjjm 5899 18 rather rather RB cord-023095-4dannjjm 5899 19 limited limited JJ cord-023095-4dannjjm 5899 20 and and CC cord-023095-4dannjjm 5899 21 mainly mainly RB cord-023095-4dannjjm 5899 22 based base VBN cord-023095-4dannjjm 5899 23 on on IN cord-023095-4dannjjm 5899 24 retrospectively retrospectively RB cord-023095-4dannjjm 5899 25 retrieved retrieve VBN cord-023095-4dannjjm 5899 26 data datum NNS cord-023095-4dannjjm 5899 27 . . . cord-023095-4dannjjm 5900 1 The the DT cord-023095-4dannjjm 5900 2 goals goal NNS cord-023095-4dannjjm 5900 3 of of IN cord-023095-4dannjjm 5900 4 this this DT cord-023095-4dannjjm 5900 5 study study NN cord-023095-4dannjjm 5900 6 were be VBD cord-023095-4dannjjm 5900 7 to to TO cord-023095-4dannjjm 5900 8 prospectively prospectively RB cord-023095-4dannjjm 5900 9 evaluate evaluate VB cord-023095-4dannjjm 5900 10 the the DT cord-023095-4dannjjm 5900 11 evolution evolution NN cord-023095-4dannjjm 5900 12 of of IN cord-023095-4dannjjm 5900 13 clinical clinical JJ cord-023095-4dannjjm 5900 14 signs sign NNS cord-023095-4dannjjm 5900 15 in in IN cord-023095-4dannjjm 5900 16 dogs dog NNS cord-023095-4dannjjm 5900 17 treated treat VBN cord-023095-4dannjjm 5900 18 conservatively conservatively RB cord-023095-4dannjjm 5900 19 for for IN cord-023095-4dannjjm 5900 20 DA DA NNP cord-023095-4dannjjm 5900 21 - - HYPH cord-023095-4dannjjm 5900 22 CSM CSM NNP cord-023095-4dannjjm 5900 23 . . . cord-023095-4dannjjm 5901 1 Additionally additionally RB cord-023095-4dannjjm 5901 2 , , , cord-023095-4dannjjm 5901 3 several several JJ cord-023095-4dannjjm 5901 4 potential potential JJ cord-023095-4dannjjm 5901 5 prognostic prognostic JJ cord-023095-4dannjjm 5901 6 parameters parameter NNS cord-023095-4dannjjm 5901 7 and and CC cord-023095-4dannjjm 5901 8 the the DT cord-023095-4dannjjm 5901 9 correlation correlation NN cord-023095-4dannjjm 5901 10 of of IN cord-023095-4dannjjm 5901 11 initial initial JJ cord-023095-4dannjjm 5901 12 clinical clinical JJ cord-023095-4dannjjm 5901 13 signs sign NNS cord-023095-4dannjjm 5901 14 with with IN cord-023095-4dannjjm 5901 15 magnetic magnetic JJ cord-023095-4dannjjm 5901 16 resonance resonance NN cord-023095-4dannjjm 5901 17 imaging imaging NN cord-023095-4dannjjm 5901 18 ( ( -LRB- cord-023095-4dannjjm 5901 19 MRI MRI NNP cord-023095-4dannjjm 5901 20 ) ) -RRB- cord-023095-4dannjjm 5901 21 and and CC cord-023095-4dannjjm 5901 22 transcranial transcranial JJ cord-023095-4dannjjm 5901 23 magnetic magnetic JJ cord-023095-4dannjjm 5901 24 stimulation stimulation NN cord-023095-4dannjjm 5901 25 ( ( -LRB- cord-023095-4dannjjm 5901 26 TMS TMS NNP cord-023095-4dannjjm 5901 27 ) ) -RRB- cord-023095-4dannjjm 5901 28 were be VBD cord-023095-4dannjjm 5901 29 investigated investigate VBN cord-023095-4dannjjm 5901 30 . . . cord-023095-4dannjjm 5902 1 Twenty twenty CD cord-023095-4dannjjm 5902 2 - - HYPH cord-023095-4dannjjm 5902 3 one one CD cord-023095-4dannjjm 5902 4 dogs dog NNS cord-023095-4dannjjm 5902 5 were be VBD cord-023095-4dannjjm 5902 6 included include VBN cord-023095-4dannjjm 5902 7 . . . cord-023095-4dannjjm 5903 1 After after IN cord-023095-4dannjjm 5903 2 neurological neurological JJ cord-023095-4dannjjm 5903 3 evaluation evaluation NN cord-023095-4dannjjm 5903 4 , , , cord-023095-4dannjjm 5903 5 neurological neurological JJ cord-023095-4dannjjm 5903 6 status status NN cord-023095-4dannjjm 5903 7 was be VBD cord-023095-4dannjjm 5903 8 graded grade VBN cord-023095-4dannjjm 5903 9 from from IN cord-023095-4dannjjm 5903 10 0 0 CD cord-023095-4dannjjm 5903 11 ( ( -LRB- cord-023095-4dannjjm 5903 12 5 5 CD cord-023095-4dannjjm 5903 13 normal normal JJ cord-023095-4dannjjm 5903 14 ) ) -RRB- cord-023095-4dannjjm 5903 15 to to IN cord-023095-4dannjjm 5903 16 6 6 CD cord-023095-4dannjjm 5903 17 ( ( -LRB- cord-023095-4dannjjm 5903 18 5 5 CD cord-023095-4dannjjm 5903 19 tetraplegia tetraplegia NNP cord-023095-4dannjjm 5903 20 ) ) -RRB- cord-023095-4dannjjm 5903 21 . . . cord-023095-4dannjjm 5904 1 All all DT cord-023095-4dannjjm 5904 2 animals animal NNS cord-023095-4dannjjm 5904 3 underwent undergo VBD cord-023095-4dannjjm 5904 4 low low JJ cord-023095-4dannjjm 5904 5 - - HYPH cord-023095-4dannjjm 5904 6 field field NN cord-023095-4dannjjm 5904 7 MRI MRI NNP cord-023095-4dannjjm 5904 8 and and CC cord-023095-4dannjjm 5904 9 TMS TMS NNP cord-023095-4dannjjm 5904 10 with with IN cord-023095-4dannjjm 5904 11 measurement measurement NN cord-023095-4dannjjm 5904 12 of of IN cord-023095-4dannjjm 5904 13 onset onset NN cord-023095-4dannjjm 5904 14 latencies latency NNS cord-023095-4dannjjm 5904 15 and and CC cord-023095-4dannjjm 5904 16 peak peak NN cord-023095-4dannjjm 5904 17 - - HYPH cord-023095-4dannjjm 5904 18 to to IN cord-023095-4dannjjm 5904 19 - - HYPH cord-023095-4dannjjm 5904 20 peak peak NN cord-023095-4dannjjm 5904 21 amplitudes amplitude NNS cord-023095-4dannjjm 5904 22 from from IN cord-023095-4dannjjm 5904 23 the the DT cord-023095-4dannjjm 5904 24 extensor extensor NN cord-023095-4dannjjm 5904 25 carpi carpi NN cord-023095-4dannjjm 5904 26 radialis radialis NN cord-023095-4dannjjm 5904 27 and and CC cord-023095-4dannjjm 5904 28 cranial cranial JJ cord-023095-4dannjjm 5904 29 tibial tibial JJ cord-023095-4dannjjm 5904 30 muscles muscle NNS cord-023095-4dannjjm 5904 31 . . . cord-023095-4dannjjm 5905 1 From from IN cord-023095-4dannjjm 5905 2 the the DT cord-023095-4dannjjm 5905 3 MR MR NNP cord-023095-4dannjjm 5905 4 images image NNS cord-023095-4dannjjm 5905 5 , , , cord-023095-4dannjjm 5905 6 the the DT cord-023095-4dannjjm 5905 7 following follow VBG cord-023095-4dannjjm 5905 8 dimensions dimension NNS cord-023095-4dannjjm 5905 9 were be VBD cord-023095-4dannjjm 5905 10 calculated calculate VBN cord-023095-4dannjjm 5905 11 : : : cord-023095-4dannjjm 5905 12 remaining remain VBG cord-023095-4dannjjm 5905 13 spinal spinal JJ cord-023095-4dannjjm 5905 14 cord cord NN cord-023095-4dannjjm 5905 15 area area NN cord-023095-4dannjjm 5905 16 ; ; : cord-023095-4dannjjm 5905 17 compression compression NN cord-023095-4dannjjm 5905 18 ratio ratio NN cord-023095-4dannjjm 5905 19 ; ; : cord-023095-4dannjjm 5905 20 vertebral vertebral JJ cord-023095-4dannjjm 5905 21 occupying occupy VBG cord-023095-4dannjjm 5905 22 ratio ratio NN cord-023095-4dannjjm 5905 23 of of IN cord-023095-4dannjjm 5905 24 the the DT cord-023095-4dannjjm 5905 25 spinal spinal JJ cord-023095-4dannjjm 5905 26 cord cord NN cord-023095-4dannjjm 5905 27 ; ; : cord-023095-4dannjjm 5905 28 canal canal NN cord-023095-4dannjjm 5905 29 height height NN cord-023095-4dannjjm 5905 30 to to IN cord-023095-4dannjjm 5905 31 body body NN cord-023095-4dannjjm 5905 32 height height NN cord-023095-4dannjjm 5905 33 ratio ratio NN cord-023095-4dannjjm 5905 34 ( ( -LRB- cord-023095-4dannjjm 5905 35 CBR CBR NNP cord-023095-4dannjjm 5905 36 ) ) -RRB- cord-023095-4dannjjm 5905 37 ; ; : cord-023095-4dannjjm 5905 38 canal canal NN cord-023095-4dannjjm 5905 39 height height NN cord-023095-4dannjjm 5905 40 to to IN cord-023095-4dannjjm 5905 41 body body NN cord-023095-4dannjjm 5905 42 length length NN cord-023095-4dannjjm 5905 43 ratio ratio NN cord-023095-4dannjjm 5905 44 ( ( -LRB- cord-023095-4dannjjm 5905 45 CBLR CBLR NNP cord-023095-4dannjjm 5905 46 ) ) -RRB- cord-023095-4dannjjm 5905 47 ; ; : cord-023095-4dannjjm 5905 48 and and CC cord-023095-4dannjjm 5905 49 the the DT cord-023095-4dannjjm 5905 50 canal canal NN cord-023095-4dannjjm 5905 51 compromise compromise NN cord-023095-4dannjjm 5905 52 ratio ratio NN cord-023095-4dannjjm 5905 53 . . . cord-023095-4dannjjm 5906 1 Intraparenchymal Intraparenchymal NNP cord-023095-4dannjjm 5906 2 intensity intensity NN cord-023095-4dannjjm 5906 3 ( ( -LRB- cord-023095-4dannjjm 5906 4 ISI ISI NNP cord-023095-4dannjjm 5906 5 ) ) -RRB- cord-023095-4dannjjm 5906 6 changes change NNS cord-023095-4dannjjm 5906 7 were be VBD cord-023095-4dannjjm 5906 8 graded grade VBN cord-023095-4dannjjm 5906 9 from from IN cord-023095-4dannjjm 5906 10 0 0 CD cord-023095-4dannjjm 5906 11 to to IN cord-023095-4dannjjm 5906 12 3 3 CD cord-023095-4dannjjm 5906 13 . . . cord-023095-4dannjjm 5907 1 All all DT cord-023095-4dannjjm 5907 2 dogs dog NNS cord-023095-4dannjjm 5907 3 were be VBD cord-023095-4dannjjm 5907 4 reevaluated reevaluate VBN cord-023095-4dannjjm 5907 5 by by IN cord-023095-4dannjjm 5907 6 the the DT cord-023095-4dannjjm 5907 7 same same JJ cord-023095-4dannjjm 5907 8 person person NN cord-023095-4dannjjm 5907 9 after after IN cord-023095-4dannjjm 5907 10 1 1 CD cord-023095-4dannjjm 5907 11 , , , cord-023095-4dannjjm 5907 12 3 3 CD cord-023095-4dannjjm 5907 13 , , , cord-023095-4dannjjm 5907 14 6 6 CD cord-023095-4dannjjm 5907 15 , , , cord-023095-4dannjjm 5907 16 12 12 CD cord-023095-4dannjjm 5907 17 , , , cord-023095-4dannjjm 5907 18 and and CC cord-023095-4dannjjm 5907 19 24 24 CD cord-023095-4dannjjm 5907 20 months month NNS cord-023095-4dannjjm 5907 21 . . . cord-023095-4dannjjm 5908 1 Eight eight CD cord-023095-4dannjjm 5908 2 of of IN cord-023095-4dannjjm 5908 3 21 21 CD cord-023095-4dannjjm 5908 4 dogs dog NNS cord-023095-4dannjjm 5908 5 ( ( -LRB- cord-023095-4dannjjm 5908 6 38 38 CD cord-023095-4dannjjm 5908 7 % % NN cord-023095-4dannjjm 5908 8 ) ) -RRB- cord-023095-4dannjjm 5908 9 experienced experience VBD cord-023095-4dannjjm 5908 10 a a DT cord-023095-4dannjjm 5908 11 positive positive JJ cord-023095-4dannjjm 5908 12 clinical clinical JJ cord-023095-4dannjjm 5908 13 evolution evolution NN cord-023095-4dannjjm 5908 14 with with IN cord-023095-4dannjjm 5908 15 improvement improvement NN cord-023095-4dannjjm 5908 16 of of IN cord-023095-4dannjjm 5908 17 clinical clinical JJ cord-023095-4dannjjm 5908 18 signs sign NNS cord-023095-4dannjjm 5908 19 or or CC cord-023095-4dannjjm 5908 20 stabilization stabilization NN cord-023095-4dannjjm 5908 21 of of IN cord-023095-4dannjjm 5908 22 mild mild JJ cord-023095-4dannjjm 5908 23 clinical clinical JJ cord-023095-4dannjjm 5908 24 signs sign NNS cord-023095-4dannjjm 5908 25 . . . cord-023095-4dannjjm 5909 1 All all DT cord-023095-4dannjjm 5909 2 dogs dog NNS cord-023095-4dannjjm 5909 3 with with IN cord-023095-4dannjjm 5909 4 a a DT cord-023095-4dannjjm 5909 5 negative negative JJ cord-023095-4dannjjm 5909 6 clinical clinical JJ cord-023095-4dannjjm 5909 7 evolution evolution NN cord-023095-4dannjjm 5909 8 1 1 CD cord-023095-4dannjjm 5909 9 month month NN cord-023095-4dannjjm 5909 10 after after IN cord-023095-4dannjjm 5909 11 diagnosis diagnosis NN cord-023095-4dannjjm 5909 12 experienced experience VBD cord-023095-4dannjjm 5909 13 a a DT cord-023095-4dannjjm 5909 14 further further JJ cord-023095-4dannjjm 5909 15 progression progression NN cord-023095-4dannjjm 5909 16 of of IN cord-023095-4dannjjm 5909 17 clinical clinical JJ cord-023095-4dannjjm 5909 18 signs sign NNS cord-023095-4dannjjm 5909 19 resulting result VBG cord-023095-4dannjjm 5909 20 in in IN cord-023095-4dannjjm 5909 21 a a DT cord-023095-4dannjjm 5909 22 poor poor JJ cord-023095-4dannjjm 5909 23 outcome outcome NN cord-023095-4dannjjm 5909 24 . . . cord-023095-4dannjjm 5910 1 The the DT cord-023095-4dannjjm 5910 2 opposite opposite JJ cord-023095-4dannjjm 5910 3 was be VBD cord-023095-4dannjjm 5910 4 true true JJ cord-023095-4dannjjm 5910 5 for for IN cord-023095-4dannjjm 5910 6 all all DT cord-023095-4dannjjm 5910 7 dogs dog NNS cord-023095-4dannjjm 5910 8 with with IN cord-023095-4dannjjm 5910 9 a a DT cord-023095-4dannjjm 5910 10 positive positive JJ cord-023095-4dannjjm 5910 11 clinical clinical JJ cord-023095-4dannjjm 5910 12 evolution evolution NN cord-023095-4dannjjm 5910 13 after after IN cord-023095-4dannjjm 5910 14 1 1 CD cord-023095-4dannjjm 5910 15 month month NN cord-023095-4dannjjm 5910 16 . . . cord-023095-4dannjjm 5911 1 Outcome outcome NN cord-023095-4dannjjm 5911 2 was be VBD cord-023095-4dannjjm 5911 3 further further RB cord-023095-4dannjjm 5911 4 significantly significantly RB cord-023095-4dannjjm 5911 5 associated associate VBN cord-023095-4dannjjm 5911 6 by by IN cord-023095-4dannjjm 5911 7 the the DT cord-023095-4dannjjm 5911 8 remaining remain VBG cord-023095-4dannjjm 5911 9 spinal spinal JJ cord-023095-4dannjjm 5911 10 cord cord NN cord-023095-4dannjjm 5911 11 area area NN cord-023095-4dannjjm 5911 12 and and CC cord-023095-4dannjjm 5911 13 the the DT cord-023095-4dannjjm 5911 14 vertebral vertebral JJ cord-023095-4dannjjm 5911 15 canal canal NN cord-023095-4dannjjm 5911 16 compromise compromise NN cord-023095-4dannjjm 5911 17 ratio ratio NN cord-023095-4dannjjm 5911 18 . . . cord-023095-4dannjjm 5912 1 Prognosis prognosis NN cord-023095-4dannjjm 5912 2 was be VBD cord-023095-4dannjjm 5912 3 not not RB cord-023095-4dannjjm 5912 4 significantly significantly RB cord-023095-4dannjjm 5912 5 affected affect VBN cord-023095-4dannjjm 5912 6 by by IN cord-023095-4dannjjm 5912 7 clinical clinical JJ cord-023095-4dannjjm 5912 8 presentation presentation NN cord-023095-4dannjjm 5912 9 or or CC cord-023095-4dannjjm 5912 10 TMS tms NN cord-023095-4dannjjm 5912 11 . . . cord-023095-4dannjjm 5913 1 Progression progression NN cord-023095-4dannjjm 5913 2 of of IN cord-023095-4dannjjm 5913 3 clinical clinical JJ cord-023095-4dannjjm 5913 4 signs sign NNS cord-023095-4dannjjm 5913 5 , , , cord-023095-4dannjjm 5913 6 in in IN cord-023095-4dannjjm 5913 7 unsuccessfully unsuccessfully RB cord-023095-4dannjjm 5913 8 treated treat VBN cord-023095-4dannjjm 5913 9 dogs dog NNS cord-023095-4dannjjm 5913 10 , , , cord-023095-4dannjjm 5913 11 was be VBD cord-023095-4dannjjm 5913 12 generally generally RB cord-023095-4dannjjm 5913 13 characterized characterize VBN cord-023095-4dannjjm 5913 14 by by IN cord-023095-4dannjjm 5913 15 a a DT cord-023095-4dannjjm 5913 16 rapid rapid JJ cord-023095-4dannjjm 5913 17 and and CC cord-023095-4dannjjm 5913 18 dramatic dramatic JJ cord-023095-4dannjjm 5913 19 deterioration deterioration NN cord-023095-4dannjjm 5913 20 of of IN cord-023095-4dannjjm 5913 21 neurological neurological JJ cord-023095-4dannjjm 5913 22 status status NN cord-023095-4dannjjm 5913 23 . . . cord-023095-4dannjjm 5914 1 There there EX cord-023095-4dannjjm 5914 2 were be VBD cord-023095-4dannjjm 5914 3 no no DT cord-023095-4dannjjm 5914 4 significant significant JJ cord-023095-4dannjjm 5914 5 correlations correlation NNS cord-023095-4dannjjm 5914 6 between between IN cord-023095-4dannjjm 5914 7 clinical clinical JJ cord-023095-4dannjjm 5914 8 presentation presentation NN cord-023095-4dannjjm 5914 9 , , , cord-023095-4dannjjm 5914 10 MRI MRI NNP cord-023095-4dannjjm 5914 11 and and CC cord-023095-4dannjjm 5914 12 TMS TMS NNP cord-023095-4dannjjm 5914 13 . . . cord-023095-4dannjjm 5915 1 Two two CD cord-023095-4dannjjm 5915 2 dogs dog NNS cord-023095-4dannjjm 5915 3 underwent undergo VBD cord-023095-4dannjjm 5915 4 necropsy necropsy JJ cord-023095-4dannjjm 5915 5 and and CC cord-023095-4dannjjm 5915 6 histopathological histopathological JJ cord-023095-4dannjjm 5915 7 examination examination NN cord-023095-4dannjjm 5915 8 . . . cord-023095-4dannjjm 5916 1 This this DT cord-023095-4dannjjm 5916 2 revealed reveal VBD cord-023095-4dannjjm 5916 3 in in IN cord-023095-4dannjjm 5916 4 both both DT cord-023095-4dannjjm 5916 5 cases case NNS cord-023095-4dannjjm 5916 6 chronic chronic JJ cord-023095-4dannjjm 5916 7 Wallerian wallerian JJ cord-023095-4dannjjm 5916 8 degeneration degeneration NN cord-023095-4dannjjm 5916 9 and and CC cord-023095-4dannjjm 5916 10 segmental segmental JJ cord-023095-4dannjjm 5916 11 myelomalacia myelomalacia NNS cord-023095-4dannjjm 5916 12 . . . cord-023095-4dannjjm 5917 1 The the DT cord-023095-4dannjjm 5917 2 results result NNS cord-023095-4dannjjm 5917 3 of of IN cord-023095-4dannjjm 5917 4 this this DT cord-023095-4dannjjm 5917 5 study study NN cord-023095-4dannjjm 5917 6 suggest suggest VBP cord-023095-4dannjjm 5917 7 that that IN cord-023095-4dannjjm 5917 8 conservative conservative JJ cord-023095-4dannjjm 5917 9 treatment treatment NN cord-023095-4dannjjm 5917 10 of of IN cord-023095-4dannjjm 5917 11 DA DA NNP cord-023095-4dannjjm 5917 12 - - HYPH cord-023095-4dannjjm 5917 13 CSM CSM NNP cord-023095-4dannjjm 5917 14 is be VBZ cord-023095-4dannjjm 5917 15 associated associate VBN cord-023095-4dannjjm 5917 16 with with IN cord-023095-4dannjjm 5917 17 a a DT cord-023095-4dannjjm 5917 18 rather rather RB cord-023095-4dannjjm 5917 19 guarded guard VBN cord-023095-4dannjjm 5917 20 prognosis prognosis NN cord-023095-4dannjjm 5917 21 . . . cord-023095-4dannjjm 5918 1 Clinical clinical JJ cord-023095-4dannjjm 5918 2 evolution evolution NN cord-023095-4dannjjm 5918 3 1 1 CD cord-023095-4dannjjm 5918 4 month month NN cord-023095-4dannjjm 5918 5 after after IN cord-023095-4dannjjm 5918 6 diagnosis diagnosis NN cord-023095-4dannjjm 5918 7 and and CC cord-023095-4dannjjm 5918 8 selected select VBN cord-023095-4dannjjm 5918 9 MRI mri NN cord-023095-4dannjjm 5918 10 parameters parameter NNS cord-023095-4dannjjm 5918 11 can can MD cord-023095-4dannjjm 5918 12 be be VB cord-023095-4dannjjm 5918 13 considered consider VBN cord-023095-4dannjjm 5918 14 as as IN cord-023095-4dannjjm 5918 15 prognostic prognostic JJ cord-023095-4dannjjm 5918 16 indicators indicator NNS cord-023095-4dannjjm 5918 17 . . . cord-023095-4dannjjm 5919 1 The the DT cord-023095-4dannjjm 5919 2 lack lack NN cord-023095-4dannjjm 5919 3 of of IN cord-023095-4dannjjm 5919 4 correlation correlation NN cord-023095-4dannjjm 5919 5 between between IN cord-023095-4dannjjm 5919 6 clinical clinical JJ cord-023095-4dannjjm 5919 7 presentation presentation NN cord-023095-4dannjjm 5919 8 and and CC cord-023095-4dannjjm 5919 9 outcome outcome NN cord-023095-4dannjjm 5919 10 , , , cord-023095-4dannjjm 5919 11 medical medical JJ cord-023095-4dannjjm 5919 12 imaging imaging NN cord-023095-4dannjjm 5919 13 and and CC cord-023095-4dannjjm 5919 14 electrophysiological electrophysiological JJ cord-023095-4dannjjm 5919 15 evaluation evaluation NN cord-023095-4dannjjm 5919 16 is be VBZ cord-023095-4dannjjm 5919 17 disturbing disturbing JJ cord-023095-4dannjjm 5919 18 and and CC cord-023095-4dannjjm 5919 19 warrants warrant NNS cord-023095-4dannjjm 5919 20 further further JJ cord-023095-4dannjjm 5919 21 investigation investigation NN cord-023095-4dannjjm 5919 22 . . . cord-023095-4dannjjm 5920 1 A a DT cord-023095-4dannjjm 5920 2 MRI MRI NNP cord-023095-4dannjjm 5920 3 - - HYPH cord-023095-4dannjjm 5920 4 guided guide VBN cord-023095-4dannjjm 5920 5 stereotactic stereotactic NNP cord-023095-4dannjjm 5920 6 brain brain NN cord-023095-4dannjjm 5920 7 biopsy biopsy NNP cord-023095-4dannjjm 5920 8 system system NN cord-023095-4dannjjm 5920 9 has have VBZ cord-023095-4dannjjm 5920 10 not not RB cord-023095-4dannjjm 5920 11 been be VBN cord-023095-4dannjjm 5920 12 clinically clinically RB cord-023095-4dannjjm 5920 13 evaluated evaluate VBN cord-023095-4dannjjm 5920 14 in in IN cord-023095-4dannjjm 5920 15 dogs dog NNS cord-023095-4dannjjm 5920 16 . . . cord-023095-4dannjjm 5921 1 The the DT cord-023095-4dannjjm 5921 2 purpose purpose NN cord-023095-4dannjjm 5921 3 of of IN cord-023095-4dannjjm 5921 4 this this DT cord-023095-4dannjjm 5921 5 study study NN cord-023095-4dannjjm 5921 6 was be VBD cord-023095-4dannjjm 5921 7 to to TO cord-023095-4dannjjm 5921 8 determine determine VB cord-023095-4dannjjm 5921 9 the the DT cord-023095-4dannjjm 5921 10 ability ability NN cord-023095-4dannjjm 5921 11 of of IN cord-023095-4dannjjm 5921 12 the the DT cord-023095-4dannjjm 5921 13 Brainsight Brainsight NNP cord-023095-4dannjjm 5921 14 TM TM NNP cord-023095-4dannjjm 5921 15 system system NN cord-023095-4dannjjm 5921 16 to to TO cord-023095-4dannjjm 5921 17 obtain obtain VB cord-023095-4dannjjm 5921 18 histologically histologically RB cord-023095-4dannjjm 5921 19 diagnostic diagnostic JJ cord-023095-4dannjjm 5921 20 samples sample NNS cord-023095-4dannjjm 5921 21 and and CC cord-023095-4dannjjm 5921 22 access access VB cord-023095-4dannjjm 5921 23 the the DT cord-023095-4dannjjm 5921 24 impact impact NN cord-023095-4dannjjm 5921 25 of of IN cord-023095-4dannjjm 5921 26 this this DT cord-023095-4dannjjm 5921 27 procedure procedure NN cord-023095-4dannjjm 5921 28 on on IN cord-023095-4dannjjm 5921 29 neurologic neurologic JJ cord-023095-4dannjjm 5921 30 status status NN cord-023095-4dannjjm 5921 31 for for IN cord-023095-4dannjjm 5921 32 72 72 CD cord-023095-4dannjjm 5921 33 hours hour NNS cord-023095-4dannjjm 5921 34 after after IN cord-023095-4dannjjm 5921 35 the the DT cord-023095-4dannjjm 5921 36 biopsy biopsy NN cord-023095-4dannjjm 5921 37 . . . cord-023095-4dannjjm 5922 1 Five five CD cord-023095-4dannjjm 5922 2 dogs dog NNS cord-023095-4dannjjm 5922 3 with with IN cord-023095-4dannjjm 5922 4 MRI MRI NNP cord-023095-4dannjjm 5922 5 definable definable JJ cord-023095-4dannjjm 5922 6 lesions lesion NNS cord-023095-4dannjjm 5922 7 in in IN cord-023095-4dannjjm 5922 8 the the DT cord-023095-4dannjjm 5922 9 brain brain NN cord-023095-4dannjjm 5922 10 have have VBP cord-023095-4dannjjm 5922 11 been be VBN cord-023095-4dannjjm 5922 12 enrolled enrol VBN cord-023095-4dannjjm 5922 13 . . . cord-023095-4dannjjm 5923 1 Breeds breed NNS cord-023095-4dannjjm 5923 2 included include VBD cord-023095-4dannjjm 5923 3 a a DT cord-023095-4dannjjm 5923 4 Pitbull Pitbull NNP cord-023095-4dannjjm 5923 5 mix mix NN cord-023095-4dannjjm 5923 6 , , , cord-023095-4dannjjm 5923 7 Pembroke Pembroke NNP cord-023095-4dannjjm 5923 8 Welsh Welsh NNP cord-023095-4dannjjm 5923 9 Corgi Corgi NNP cord-023095-4dannjjm 5923 10 , , , cord-023095-4dannjjm 5923 11 French french JJ cord-023095-4dannjjm 5923 12 Bulldog Bulldog NNP cord-023095-4dannjjm 5923 13 , , , cord-023095-4dannjjm 5923 14 Border Border NNP cord-023095-4dannjjm 5923 15 Terrier Terrier NNP cord-023095-4dannjjm 5923 16 and and CC cord-023095-4dannjjm 5923 17 West West NNP cord-023095-4dannjjm 5923 18 Highland Highland NNP cord-023095-4dannjjm 5923 19 White White NNP cord-023095-4dannjjm 5923 20 Terrier Terrier NNP cord-023095-4dannjjm 5923 21 . . . cord-023095-4dannjjm 5924 1 Age age NN cord-023095-4dannjjm 5924 2 ranged range VBD cord-023095-4dannjjm 5924 3 from from IN cord-023095-4dannjjm 5924 4 5 5 CD cord-023095-4dannjjm 5924 5 - - SYM cord-023095-4dannjjm 5924 6 11 11 CD cord-023095-4dannjjm 5924 7 years year NNS cord-023095-4dannjjm 5924 8 . . . cord-023095-4dannjjm 5925 1 Weight weight NN cord-023095-4dannjjm 5925 2 ranged range VBD cord-023095-4dannjjm 5925 3 from from IN cord-023095-4dannjjm 5925 4 8.5 8.5 CD cord-023095-4dannjjm 5925 5 - - HYPH cord-023095-4dannjjm 5925 6 18.8 18.8 CD cord-023095-4dannjjm 5925 7 kg kg NNS cord-023095-4dannjjm 5925 8 . . . cord-023095-4dannjjm 5926 1 Dogs dog NNS cord-023095-4dannjjm 5926 2 presented present VBN cord-023095-4dannjjm 5926 3 with with IN cord-023095-4dannjjm 5926 4 seizures seizure NNS cord-023095-4dannjjm 5926 5 ( ( -LRB- cord-023095-4dannjjm 5926 6 n n NN cord-023095-4dannjjm 5926 7 5 5 CD cord-023095-4dannjjm 5926 8 5 5 CD cord-023095-4dannjjm 5926 9 ) ) -RRB- cord-023095-4dannjjm 5926 10 , , , cord-023095-4dannjjm 5926 11 ambulatory ambulatory JJ cord-023095-4dannjjm 5926 12 paresis(n paresis(n NNP cord-023095-4dannjjm 5926 13 5 5 CD cord-023095-4dannjjm 5926 14 4 4 CD cord-023095-4dannjjm 5926 15 ) ) -RRB- cord-023095-4dannjjm 5926 16 , , , cord-023095-4dannjjm 5926 17 unilateral unilateral JJ cord-023095-4dannjjm 5926 18 blindness(n blindness(n NNP cord-023095-4dannjjm 5926 19 5 5 CD cord-023095-4dannjjm 5926 20 2 2 CD cord-023095-4dannjjm 5926 21 ) ) -RRB- cord-023095-4dannjjm 5926 22 and and CC cord-023095-4dannjjm 5926 23 head head NN cord-023095-4dannjjm 5926 24 tilt(n tilt(n NNP cord-023095-4dannjjm 5926 25 5 5 CD cord-023095-4dannjjm 5926 26 1 1 CD cord-023095-4dannjjm 5926 27 ) ) -RRB- cord-023095-4dannjjm 5926 28 . . . cord-023095-4dannjjm 5927 1 One one CD cord-023095-4dannjjm 5927 2 dog dog NN cord-023095-4dannjjm 5927 3 had have VBD cord-023095-4dannjjm 5927 4 a a DT cord-023095-4dannjjm 5927 5 normal normal JJ cord-023095-4dannjjm 5927 6 neurologic neurologic JJ cord-023095-4dannjjm 5927 7 exam exam NN cord-023095-4dannjjm 5927 8 . . . cord-023095-4dannjjm 5928 1 Lesions lesion NNS cord-023095-4dannjjm 5928 2 chosen choose VBN cord-023095-4dannjjm 5928 3 for for IN cord-023095-4dannjjm 5928 4 biopsy biopsy NN cord-023095-4dannjjm 5928 5 were be VBD cord-023095-4dannjjm 5928 6 in in IN cord-023095-4dannjjm 5928 7 the the DT cord-023095-4dannjjm 5928 8 olfactory olfactory NN cord-023095-4dannjjm 5928 9 and/or and/or CC cord-023095-4dannjjm 5928 10 frontal frontal JJ cord-023095-4dannjjm 5928 11 lobes lobe NNS cord-023095-4dannjjm 5928 12 ( ( -LRB- cord-023095-4dannjjm 5928 13 n n NN cord-023095-4dannjjm 5928 14 5 5 CD cord-023095-4dannjjm 5928 15 3 3 CD cord-023095-4dannjjm 5928 16 ) ) -RRB- cord-023095-4dannjjm 5928 17 , , , cord-023095-4dannjjm 5928 18 parietal parietal JJ cord-023095-4dannjjm 5928 19 lobe(n lobe(n NNP cord-023095-4dannjjm 5928 20 5 5 CD cord-023095-4dannjjm 5928 21 1 1 CD cord-023095-4dannjjm 5928 22 ) ) -RRB- cord-023095-4dannjjm 5928 23 , , , cord-023095-4dannjjm 5928 24 and and CC cord-023095-4dannjjm 5928 25 pyriform pyriform NNP cord-023095-4dannjjm 5928 26 lobe(n lobe(n NNP cord-023095-4dannjjm 5928 27 5 5 CD cord-023095-4dannjjm 5928 28 1 1 CD cord-023095-4dannjjm 5928 29 ) ) -RRB- cord-023095-4dannjjm 5928 30 . . . cord-023095-4dannjjm 5929 1 Lesions lesion NNS cord-023095-4dannjjm 5929 2 were be VBD cord-023095-4dannjjm 5929 3 between between IN cord-023095-4dannjjm 5929 4 14 14 CD cord-023095-4dannjjm 5929 5 - - SYM cord-023095-4dannjjm 5929 6 22 22 CD cord-023095-4dannjjm 5929 7 mm mm NNS cord-023095-4dannjjm 5929 8 in in IN cord-023095-4dannjjm 5929 9 diameter diameter NN cord-023095-4dannjjm 5929 10 . . . cord-023095-4dannjjm 5930 1 All all DT cord-023095-4dannjjm 5930 2 lesions lesion NNS cord-023095-4dannjjm 5930 3 were be VBD cord-023095-4dannjjm 5930 4 well well RB cord-023095-4dannjjm 5930 5 - - HYPH cord-023095-4dannjjm 5930 6 circumscribed circumscribe VBN cord-023095-4dannjjm 5930 7 and and CC cord-023095-4dannjjm 5930 8 contrast contrast NN cord-023095-4dannjjm 5930 9 enhancing enhancing NN cord-023095-4dannjjm 5930 10 except except IN cord-023095-4dannjjm 5930 11 for for IN cord-023095-4dannjjm 5930 12 one one CD cord-023095-4dannjjm 5930 13 . . . cord-023095-4dannjjm 5931 1 Histologic Histologic NNP cord-023095-4dannjjm 5931 2 diagnosis diagnosis NN cord-023095-4dannjjm 5931 3 of of IN cord-023095-4dannjjm 5931 4 meningioma(n meningioma(n NNP cord-023095-4dannjjm 5931 5 5 5 CD cord-023095-4dannjjm 5931 6 3 3 CD cord-023095-4dannjjm 5931 7 ) ) -RRB- cord-023095-4dannjjm 5931 8 and and CC cord-023095-4dannjjm 5931 9 granulomatous granulomatous JJ cord-023095-4dannjjm 5931 10 meningoencephalitis(n meningoencephalitis(n NNP cord-023095-4dannjjm 5931 11 5 5 CD cord-023095-4dannjjm 5931 12 1 1 CD cord-023095-4dannjjm 5931 13 ) ) -RRB- cord-023095-4dannjjm 5931 14 were be VBD cord-023095-4dannjjm 5931 15 made make VBN cord-023095-4dannjjm 5931 16 . . . cord-023095-4dannjjm 5932 1 The the DT cord-023095-4dannjjm 5932 2 poorly poorly RB cord-023095-4dannjjm 5932 3 - - HYPH cord-023095-4dannjjm 5932 4 circumscribed circumscribed JJ cord-023095-4dannjjm 5932 5 , , , cord-023095-4dannjjm 5932 6 non non JJ cord-023095-4dannjjm 5932 7 - - JJ cord-023095-4dannjjm 5932 8 contrast contrast JJ cord-023095-4dannjjm 5932 9 enhancing enhance VBG cord-023095-4dannjjm 5932 10 frontal frontal JJ cord-023095-4dannjjm 5932 11 mass mass NN cord-023095-4dannjjm 5932 12 yielded yield VBN cord-023095-4dannjjm 5932 13 non non JJ cord-023095-4dannjjm 5932 14 - - JJ cord-023095-4dannjjm 5932 15 specific specific JJ cord-023095-4dannjjm 5932 16 necrosis necrosis NN cord-023095-4dannjjm 5932 17 . . . cord-023095-4dannjjm 5933 1 Following follow VBG cord-023095-4dannjjm 5933 2 biopsy biopsy NN cord-023095-4dannjjm 5933 3 , , , cord-023095-4dannjjm 5933 4 three three CD cord-023095-4dannjjm 5933 5 dogs dog NNS cord-023095-4dannjjm 5933 6 returned return VBD cord-023095-4dannjjm 5933 7 to to IN cord-023095-4dannjjm 5933 8 pre pre JJ cord-023095-4dannjjm 5933 9 - - JJ cord-023095-4dannjjm 5933 10 biopsy biopsy JJ cord-023095-4dannjjm 5933 11 neurologic neurologic JJ cord-023095-4dannjjm 5933 12 status status NN cord-023095-4dannjjm 5933 13 within within IN cord-023095-4dannjjm 5933 14 12 12 CD cord-023095-4dannjjm 5933 15 hours hour NNS cord-023095-4dannjjm 5933 16 . . . cord-023095-4dannjjm 5934 1 The the DT cord-023095-4dannjjm 5934 2 French french JJ cord-023095-4dannjjm 5934 3 Bulldog Bulldog NNP cord-023095-4dannjjm 5934 4 took take VBD cord-023095-4dannjjm 5934 5 48 48 CD cord-023095-4dannjjm 5934 6 hours hour NNS cord-023095-4dannjjm 5934 7 to to TO cord-023095-4dannjjm 5934 8 return return VB cord-023095-4dannjjm 5934 9 to to IN cord-023095-4dannjjm 5934 10 previous previous JJ cord-023095-4dannjjm 5934 11 neurologic neurologic JJ cord-023095-4dannjjm 5934 12 status status NN cord-023095-4dannjjm 5934 13 due due IN cord-023095-4dannjjm 5934 14 to to IN cord-023095-4dannjjm 5934 15 brachycephalic brachycephalic JJ cord-023095-4dannjjm 5934 16 syndrome syndrome NN cord-023095-4dannjjm 5934 17 that that WDT cord-023095-4dannjjm 5934 18 required require VBD cord-023095-4dannjjm 5934 19 oxygen oxygen NN cord-023095-4dannjjm 5934 20 support support NN cord-023095-4dannjjm 5934 21 . . . cord-023095-4dannjjm 5935 1 One one CD cord-023095-4dannjjm 5935 2 dog dog NN cord-023095-4dannjjm 5935 3 had have VBD cord-023095-4dannjjm 5935 4 acute acute JJ cord-023095-4dannjjm 5935 5 respiratory respiratory JJ cord-023095-4dannjjm 5935 6 arrest arrest NN cord-023095-4dannjjm 5935 7 16 16 CD cord-023095-4dannjjm 5935 8 hours hour NNS cord-023095-4dannjjm 5935 9 post post NN cord-023095-4dannjjm 5935 10 - - NN cord-023095-4dannjjm 5935 11 biopsy biopsy JJ cord-023095-4dannjjm 5935 12 . . . cord-023095-4dannjjm 5936 1 Necropsy Necropsy NNP cord-023095-4dannjjm 5936 2 is be VBZ cord-023095-4dannjjm 5936 3 pending pende VBG cord-023095-4dannjjm 5936 4 . . . cord-023095-4dannjjm 5937 1 These these DT cord-023095-4dannjjm 5937 2 results result NNS cord-023095-4dannjjm 5937 3 suggest suggest VBP cord-023095-4dannjjm 5937 4 that that IN cord-023095-4dannjjm 5937 5 this this DT cord-023095-4dannjjm 5937 6 MRI MRI NNP cord-023095-4dannjjm 5937 7 - - HYPH cord-023095-4dannjjm 5937 8 guided guide VBN cord-023095-4dannjjm 5937 9 biopsy biopsy NN cord-023095-4dannjjm 5937 10 system system NN cord-023095-4dannjjm 5937 11 can can MD cord-023095-4dannjjm 5937 12 provide provide VB cord-023095-4dannjjm 5937 13 an an DT cord-023095-4dannjjm 5937 14 accurate accurate JJ cord-023095-4dannjjm 5937 15 histologic histologic JJ cord-023095-4dannjjm 5937 16 diagnosis diagnosis NN cord-023095-4dannjjm 5937 17 of of IN cord-023095-4dannjjm 5937 18 brain brain NN cord-023095-4dannjjm 5937 19 lesions lesion NNS cord-023095-4dannjjm 5937 20 . . . cord-023095-4dannjjm 5938 1 Biopsies biopsy NNS cord-023095-4dannjjm 5938 2 of of IN cord-023095-4dannjjm 5938 3 poorly poorly RB cord-023095-4dannjjm 5938 4 - - HYPH cord-023095-4dannjjm 5938 5 circumscribed circumscribed JJ cord-023095-4dannjjm 5938 6 and and CC cord-023095-4dannjjm 5938 7 non non JJ cord-023095-4dannjjm 5938 8 - - JJ cord-023095-4dannjjm 5938 9 contrast contrast JJ cord-023095-4dannjjm 5938 10 enhancing enhance VBG cord-023095-4dannjjm 5938 11 brain brain NN cord-023095-4dannjjm 5938 12 lesions lesion NNS cord-023095-4dannjjm 5938 13 may may MD cord-023095-4dannjjm 5938 14 be be VB cord-023095-4dannjjm 5938 15 less less RBR cord-023095-4dannjjm 5938 16 diagnostic diagnostic JJ cord-023095-4dannjjm 5938 17 . . . cord-023095-4dannjjm 5939 1 Further further JJ cord-023095-4dannjjm 5939 2 evaluation evaluation NN cord-023095-4dannjjm 5939 3 is be VBZ cord-023095-4dannjjm 5939 4 on on RB cord-023095-4dannjjm 5939 5 - - HYPH cord-023095-4dannjjm 5939 6 going go VBG cord-023095-4dannjjm 5939 7 to to TO cord-023095-4dannjjm 5939 8 determine determine VB cord-023095-4dannjjm 5939 9 the the DT cord-023095-4dannjjm 5939 10 true true JJ cord-023095-4dannjjm 5939 11 diagnostic diagnostic JJ cord-023095-4dannjjm 5939 12 yield yield NN cord-023095-4dannjjm 5939 13 and and CC cord-023095-4dannjjm 5939 14 complication complication NN cord-023095-4dannjjm 5939 15 rate rate NN cord-023095-4dannjjm 5939 16 of of IN cord-023095-4dannjjm 5939 17 this this DT cord-023095-4dannjjm 5939 18 procedure procedure NN cord-023095-4dannjjm 5939 19 . . . cord-023095-4dannjjm 5940 1 Concurrent concurrent JJ cord-023095-4dannjjm 5940 2 malformations malformation NNS cord-023095-4dannjjm 5940 3 of of IN cord-023095-4dannjjm 5940 4 the the DT cord-023095-4dannjjm 5940 5 craniocervical craniocervical NNP cord-023095-4dannjjm 5940 6 junction junction NNP cord-023095-4dannjjm 5940 7 are be VBP cord-023095-4dannjjm 5940 8 commonly commonly RB cord-023095-4dannjjm 5940 9 identified identify VBN cord-023095-4dannjjm 5940 10 in in IN cord-023095-4dannjjm 5940 11 humans human NNS cord-023095-4dannjjm 5940 12 with with IN cord-023095-4dannjjm 5940 13 Chiari Chiari NNP cord-023095-4dannjjm 5940 14 type type NN cord-023095-4dannjjm 5940 15 I -PRON- PRP cord-023095-4dannjjm 5940 16 malformation malformation NN cord-023095-4dannjjm 5940 17 . . . cord-023095-4dannjjm 5941 1 Recent recent JJ cord-023095-4dannjjm 5941 2 evidence evidence NN cord-023095-4dannjjm 5941 3 suggests suggest VBZ cord-023095-4dannjjm 5941 4 such such JJ cord-023095-4dannjjm 5941 5 craniocervical craniocervical JJ cord-023095-4dannjjm 5941 6 junction junction NN cord-023095-4dannjjm 5941 7 abnormalities abnormality NNS cord-023095-4dannjjm 5941 8 ( ( -LRB- cord-023095-4dannjjm 5941 9 CJAs CJAs NNP cord-023095-4dannjjm 5941 10 ) ) -RRB- cord-023095-4dannjjm 5941 11 also also RB cord-023095-4dannjjm 5941 12 occur occur VBP cord-023095-4dannjjm 5941 13 in in IN cord-023095-4dannjjm 5941 14 dogs dog NNS cord-023095-4dannjjm 5941 15 suspected suspect VBN cord-023095-4dannjjm 5941 16 of of IN cord-023095-4dannjjm 5941 17 having have VBG cord-023095-4dannjjm 5941 18 Chiari Chiari NNP cord-023095-4dannjjm 5941 19 - - HYPH cord-023095-4dannjjm 5941 20 like like JJ cord-023095-4dannjjm 5941 21 malformation malformation NN cord-023095-4dannjjm 5941 22 ( ( -LRB- cord-023095-4dannjjm 5941 23 CLM CLM NNP cord-023095-4dannjjm 5941 24 ) ) -RRB- cord-023095-4dannjjm 5941 25 . . . cord-023095-4dannjjm 5942 1 The the DT cord-023095-4dannjjm 5942 2 purpose purpose NN cord-023095-4dannjjm 5942 3 of of IN cord-023095-4dannjjm 5942 4 this this DT cord-023095-4dannjjm 5942 5 study study NN cord-023095-4dannjjm 5942 6 was be VBD cord-023095-4dannjjm 5942 7 to to TO cord-023095-4dannjjm 5942 8 objectively objectively RB cord-023095-4dannjjm 5942 9 describe describe VB cord-023095-4dannjjm 5942 10 morphometric morphometric JJ cord-023095-4dannjjm 5942 11 features feature NNS cord-023095-4dannjjm 5942 12 of of IN cord-023095-4dannjjm 5942 13 the the DT cord-023095-4dannjjm 5942 14 craniocervical craniocervical NNP cord-023095-4dannjjm 5942 15 junction junction NN cord-023095-4dannjjm 5942 16 region region NN cord-023095-4dannjjm 5942 17 of of IN cord-023095-4dannjjm 5942 18 dogs dog NNS cord-023095-4dannjjm 5942 19 with with IN cord-023095-4dannjjm 5942 20 suspected suspect VBN cord-023095-4dannjjm 5942 21 CLM CLM NNP cord-023095-4dannjjm 5942 22 and and CC cord-023095-4dannjjm 5942 23 to to TO cord-023095-4dannjjm 5942 24 investigate investigate VB cord-023095-4dannjjm 5942 25 for for IN cord-023095-4dannjjm 5942 26 associations association NNS cord-023095-4dannjjm 5942 27 between between IN cord-023095-4dannjjm 5942 28 these these DT cord-023095-4dannjjm 5942 29 features feature NNS cord-023095-4dannjjm 5942 30 and and CC cord-023095-4dannjjm 5942 31 the the DT cord-023095-4dannjjm 5942 32 occurrence occurrence NN cord-023095-4dannjjm 5942 33 of of IN cord-023095-4dannjjm 5942 34 other other JJ cord-023095-4dannjjm 5942 35 malformations malformation NNS cord-023095-4dannjjm 5942 36 in in IN cord-023095-4dannjjm 5942 37 this this DT cord-023095-4dannjjm 5942 38 region region NN cord-023095-4dannjjm 5942 39 . . . cord-023095-4dannjjm 5943 1 Magnetic magnetic JJ cord-023095-4dannjjm 5943 2 resonance resonance NN cord-023095-4dannjjm 5943 3 ( ( -LRB- cord-023095-4dannjjm 5943 4 MR MR NNP cord-023095-4dannjjm 5943 5 ) ) -RRB- cord-023095-4dannjjm 5943 6 and and CC cord-023095-4dannjjm 5943 7 computed compute VBN cord-023095-4dannjjm 5943 8 tomographic tomographic NNP cord-023095-4dannjjm 5943 9 ( ( -LRB- cord-023095-4dannjjm 5943 10 CT CT NNP cord-023095-4dannjjm 5943 11 ) ) -RRB- cord-023095-4dannjjm 5943 12 images image NNS cord-023095-4dannjjm 5943 13 from from IN cord-023095-4dannjjm 5943 14 274 274 CD cord-023095-4dannjjm 5943 15 dogs dog NNS cord-023095-4dannjjm 5943 16 with with IN cord-023095-4dannjjm 5943 17 CLM CLM NNP cord-023095-4dannjjm 5943 18 were be VBD cord-023095-4dannjjm 5943 19 evaluated evaluate VBN cord-023095-4dannjjm 5943 20 . . . cord-023095-4dannjjm 5944 1 Three three CD cord-023095-4dannjjm 5944 2 regions region NNS cord-023095-4dannjjm 5944 3 of of IN cord-023095-4dannjjm 5944 4 neural neural JJ cord-023095-4dannjjm 5944 5 tissue tissue NN cord-023095-4dannjjm 5944 6 compression compression NN cord-023095-4dannjjm 5944 7 were be VBD cord-023095-4dannjjm 5944 8 assessed assess VBN cord-023095-4dannjjm 5944 9 : : : cord-023095-4dannjjm 5944 10 cerebellar cerebellar JJ cord-023095-4dannjjm 5944 11 compression compression NN cord-023095-4dannjjm 5944 12 ( ( -LRB- cord-023095-4dannjjm 5944 13 CC cc NN cord-023095-4dannjjm 5944 14 ) ) -RRB- cord-023095-4dannjjm 5944 15 ; ; , cord-023095-4dannjjm 5944 16 ventral ventral JJ cord-023095-4dannjjm 5944 17 compression compression NN cord-023095-4dannjjm 5944 18 at at IN cord-023095-4dannjjm 5944 19 the the DT cord-023095-4dannjjm 5944 20 C1 C1 NNP cord-023095-4dannjjm 5944 21 / / SYM cord-023095-4dannjjm 5944 22 C2 C2 NNP cord-023095-4dannjjm 5944 23 articulation articulation NN cord-023095-4dannjjm 5944 24 , , , cord-023095-4dannjjm 5944 25 termed term VBN cord-023095-4dannjjm 5944 26 ' ' `` cord-023095-4dannjjm 5944 27 ' ' `` cord-023095-4dannjjm 5944 28 medullary medullary JJ cord-023095-4dannjjm 5944 29 kinking kinking NN cord-023095-4dannjjm 5944 30 ' ' '' cord-023095-4dannjjm 5944 31 ' ' '' cord-023095-4dannjjm 5944 32 ( ( -LRB- cord-023095-4dannjjm 5944 33 MK MK NNP cord-023095-4dannjjm 5944 34 ) ) -RRB- cord-023095-4dannjjm 5944 35 ; ; : cord-023095-4dannjjm 5944 36 and and CC cord-023095-4dannjjm 5944 37 dorsal dorsal JJ cord-023095-4dannjjm 5944 38 compression compression NN cord-023095-4dannjjm 5944 39 ( ( -LRB- cord-023095-4dannjjm 5944 40 DC DC NNP cord-023095-4dannjjm 5944 41 ) ) -RRB- cord-023095-4dannjjm 5944 42 at at IN cord-023095-4dannjjm 5944 43 the the DT cord-023095-4dannjjm 5944 44 C1 C1 NNP cord-023095-4dannjjm 5944 45 / / SYM cord-023095-4dannjjm 5944 46 C2 C2 NNP cord-023095-4dannjjm 5944 47 articulation articulation NN cord-023095-4dannjjm 5944 48 . . . cord-023095-4dannjjm 5945 1 A a DT cord-023095-4dannjjm 5945 2 compression compression NN cord-023095-4dannjjm 5945 3 index index NN cord-023095-4dannjjm 5945 4 ( ( -LRB- cord-023095-4dannjjm 5945 5 CI CI NNP cord-023095-4dannjjm 5945 6 ) ) -RRB- cord-023095-4dannjjm 5945 7 was be VBD cord-023095-4dannjjm 5945 8 calculated calculate VBN cord-023095-4dannjjm 5945 9 for for IN cord-023095-4dannjjm 5945 10 all all DT cord-023095-4dannjjm 5945 11 abnormal abnormal JJ cord-023095-4dannjjm 5945 12 regions region NNS cord-023095-4dannjjm 5945 13 for for IN cord-023095-4dannjjm 5945 14 each each DT cord-023095-4dannjjm 5945 15 dog dog NN cord-023095-4dannjjm 5945 16 . . . cord-023095-4dannjjm 5946 1 Multiple multiple JJ cord-023095-4dannjjm 5946 2 logistic logistic JJ cord-023095-4dannjjm 5946 3 regression regression NN cord-023095-4dannjjm 5946 4 analysis analysis NN cord-023095-4dannjjm 5946 5 was be VBD cord-023095-4dannjjm 5946 6 performed perform VBN cord-023095-4dannjjm 5946 7 ( ( -LRB- cord-023095-4dannjjm 5946 8 p p NN cord-023095-4dannjjm 5946 9 o o NN cord-023095-4dannjjm 5946 10 0.05 0.05 CD cord-023095-4dannjjm 5946 11 ) ) -RRB- cord-023095-4dannjjm 5946 12 to to TO cord-023095-4dannjjm 5946 13 ascertain ascertain VB cord-023095-4dannjjm 5946 14 whether whether IN cord-023095-4dannjjm 5946 15 CI CI NNP cord-023095-4dannjjm 5946 16 values value NNS cord-023095-4dannjjm 5946 17 for for IN cord-023095-4dannjjm 5946 18 the the DT cord-023095-4dannjjm 5946 19 different different JJ cord-023095-4dannjjm 5946 20 regions region NNS cord-023095-4dannjjm 5946 21 of of IN cord-023095-4dannjjm 5946 22 compression compression NN cord-023095-4dannjjm 5946 23 were be VBD cord-023095-4dannjjm 5946 24 associated associate VBN cord-023095-4dannjjm 5946 25 with with IN cord-023095-4dannjjm 5946 26 the the DT cord-023095-4dannjjm 5946 27 incidence incidence NN cord-023095-4dannjjm 5946 28 of of IN cord-023095-4dannjjm 5946 29 other other JJ cord-023095-4dannjjm 5946 30 craniocervical craniocervical JJ cord-023095-4dannjjm 5946 31 junction junction NN cord-023095-4dannjjm 5946 32 abnormalities abnormality NNS cord-023095-4dannjjm 5946 33 . . . cord-023095-4dannjjm 5947 1 68 68 CD cord-023095-4dannjjm 5947 2 % % NN cord-023095-4dannjjm 5947 3 of of IN cord-023095-4dannjjm 5947 4 dogs dog NNS cord-023095-4dannjjm 5947 5 had have VBD cord-023095-4dannjjm 5947 6 MK MK NNP cord-023095-4dannjjm 5947 7 and and CC cord-023095-4dannjjm 5947 8 38 38 CD cord-023095-4dannjjm 5947 9 % % NN cord-023095-4dannjjm 5947 10 of of IN cord-023095-4dannjjm 5947 11 dogs dog NNS cord-023095-4dannjjm 5947 12 had have VBD cord-023095-4dannjjm 5947 13 DC DC NNP cord-023095-4dannjjm 5947 14 . . . cord-023095-4dannjjm 5948 1 28 28 CD cord-023095-4dannjjm 5948 2 % % NN cord-023095-4dannjjm 5948 3 of of IN cord-023095-4dannjjm 5948 4 dogs dog NNS cord-023095-4dannjjm 5948 5 also also RB cord-023095-4dannjjm 5948 6 had have VBD cord-023095-4dannjjm 5948 7 evidence evidence NN cord-023095-4dannjjm 5948 8 of of IN cord-023095-4dannjjm 5948 9 atlanto atlanto NNS cord-023095-4dannjjm 5948 10 - - HYPH cord-023095-4dannjjm 5948 11 occipital occipital JJ cord-023095-4dannjjm 5948 12 overlapping overlap VBG cord-023095-4dannjjm 5948 13 ( ( -LRB- cord-023095-4dannjjm 5948 14 AOO AOO NNP cord-023095-4dannjjm 5948 15 Medical medical JJ cord-023095-4dannjjm 5948 16 infrared infrared JJ cord-023095-4dannjjm 5948 17 imaging imaging NN cord-023095-4dannjjm 5948 18 ( ( -LRB- cord-023095-4dannjjm 5948 19 MII MII NNP cord-023095-4dannjjm 5948 20 ) ) -RRB- cord-023095-4dannjjm 5948 21 is be VBZ cord-023095-4dannjjm 5948 22 a a DT cord-023095-4dannjjm 5948 23 non non JJ cord-023095-4dannjjm 5948 24 - - JJ cord-023095-4dannjjm 5948 25 invasive invasive JJ cord-023095-4dannjjm 5948 26 diagnostic diagnostic JJ cord-023095-4dannjjm 5948 27 imaging imaging NN cord-023095-4dannjjm 5948 28 technique technique NN cord-023095-4dannjjm 5948 29 that that WDT cord-023095-4dannjjm 5948 30 measures measure VBZ cord-023095-4dannjjm 5948 31 skin skin NN cord-023095-4dannjjm 5948 32 surface surface NN cord-023095-4dannjjm 5948 33 temperature temperature NN cord-023095-4dannjjm 5948 34 and and CC cord-023095-4dannjjm 5948 35 generates generate VBZ cord-023095-4dannjjm 5948 36 thermal thermal JJ cord-023095-4dannjjm 5948 37 pattern pattern NN cord-023095-4dannjjm 5948 38 maps map NNS cord-023095-4dannjjm 5948 39 based base VBN cord-023095-4dannjjm 5948 40 on on IN cord-023095-4dannjjm 5948 41 predetermined predetermine VBN cord-023095-4dannjjm 5948 42 color color NN cord-023095-4dannjjm 5948 43 scales scale NNS cord-023095-4dannjjm 5948 44 . . . cord-023095-4dannjjm 5949 1 Because because IN cord-023095-4dannjjm 5949 2 skin skin NN cord-023095-4dannjjm 5949 3 temperature temperature NN cord-023095-4dannjjm 5949 4 , , , cord-023095-4dannjjm 5949 5 dependent dependent JJ cord-023095-4dannjjm 5949 6 on on IN cord-023095-4dannjjm 5949 7 regional regional JJ cord-023095-4dannjjm 5949 8 perfusion perfusion NN cord-023095-4dannjjm 5949 9 , , , cord-023095-4dannjjm 5949 10 is be VBZ cord-023095-4dannjjm 5949 11 under under IN cord-023095-4dannjjm 5949 12 direct direct JJ cord-023095-4dannjjm 5949 13 control control NN cord-023095-4dannjjm 5949 14 of of IN cord-023095-4dannjjm 5949 15 the the DT cord-023095-4dannjjm 5949 16 sympathetic sympathetic JJ cord-023095-4dannjjm 5949 17 nervous nervous JJ cord-023095-4dannjjm 5949 18 system system NN cord-023095-4dannjjm 5949 19 , , , cord-023095-4dannjjm 5949 20 MII MII NNP cord-023095-4dannjjm 5949 21 provides provide VBZ cord-023095-4dannjjm 5949 22 information information NN cord-023095-4dannjjm 5949 23 about about IN cord-023095-4dannjjm 5949 24 the the DT cord-023095-4dannjjm 5949 25 function function NN cord-023095-4dannjjm 5949 26 of of IN cord-023095-4dannjjm 5949 27 the the DT cord-023095-4dannjjm 5949 28 autonomic autonomic JJ cord-023095-4dannjjm 5949 29 nervous nervous JJ cord-023095-4dannjjm 5949 30 system system NN cord-023095-4dannjjm 5949 31 . . . cord-023095-4dannjjm 5950 1 Because because IN cord-023095-4dannjjm 5950 2 of of IN cord-023095-4dannjjm 5950 3 recent recent JJ cord-023095-4dannjjm 5950 4 advances advance NNS cord-023095-4dannjjm 5950 5 in in IN cord-023095-4dannjjm 5950 6 technology technology NN cord-023095-4dannjjm 5950 7 and and CC cord-023095-4dannjjm 5950 8 lack lack NN cord-023095-4dannjjm 5950 9 of of IN cord-023095-4dannjjm 5950 10 sedation sedation NN cord-023095-4dannjjm 5950 11 needed need VBN cord-023095-4dannjjm 5950 12 to to TO cord-023095-4dannjjm 5950 13 image image VB cord-023095-4dannjjm 5950 14 patients patient NNS cord-023095-4dannjjm 5950 15 , , , cord-023095-4dannjjm 5950 16 MII MII NNP cord-023095-4dannjjm 5950 17 has have VBZ cord-023095-4dannjjm 5950 18 potential potential JJ cord-023095-4dannjjm 5950 19 use use NN cord-023095-4dannjjm 5950 20 as as IN cord-023095-4dannjjm 5950 21 a a DT cord-023095-4dannjjm 5950 22 screening screening NN cord-023095-4dannjjm 5950 23 test test NN cord-023095-4dannjjm 5950 24 for for IN cord-023095-4dannjjm 5950 25 a a DT cord-023095-4dannjjm 5950 26 variety variety NN cord-023095-4dannjjm 5950 27 of of IN cord-023095-4dannjjm 5950 28 conditions condition NNS cord-023095-4dannjjm 5950 29 that that WDT cord-023095-4dannjjm 5950 30 may may MD cord-023095-4dannjjm 5950 31 result result VB cord-023095-4dannjjm 5950 32 in in IN cord-023095-4dannjjm 5950 33 autonomic autonomic JJ cord-023095-4dannjjm 5950 34 dysregulation dysregulation NN cord-023095-4dannjjm 5950 35 like like IN cord-023095-4dannjjm 5950 36 Chiari Chiari NNP cord-023095-4dannjjm 5950 37 - - HYPH cord-023095-4dannjjm 5950 38 like like JJ cord-023095-4dannjjm 5950 39 malformation malformation NN cord-023095-4dannjjm 5950 40 in in IN cord-023095-4dannjjm 5950 41 dogs dog NNS cord-023095-4dannjjm 5950 42 ( ( -LRB- cord-023095-4dannjjm 5950 43 CLM CLM NNP cord-023095-4dannjjm 5950 44 ) ) -RRB- cord-023095-4dannjjm 5950 45 . . . cord-023095-4dannjjm 5951 1 The the DT cord-023095-4dannjjm 5951 2 purposes purpose NNS cord-023095-4dannjjm 5951 3 of of IN cord-023095-4dannjjm 5951 4 this this DT cord-023095-4dannjjm 5951 5 study study NN cord-023095-4dannjjm 5951 6 were be VBD cord-023095-4dannjjm 5951 7 to to TO cord-023095-4dannjjm 5951 8 establish establish VB cord-023095-4dannjjm 5951 9 a a DT cord-023095-4dannjjm 5951 10 MII MII NNP cord-023095-4dannjjm 5951 11 protocol protocol NN cord-023095-4dannjjm 5951 12 for for IN cord-023095-4dannjjm 5951 13 dogs dog NNS cord-023095-4dannjjm 5951 14 suspected suspect VBN cord-023095-4dannjjm 5951 15 of of IN cord-023095-4dannjjm 5951 16 having have VBG cord-023095-4dannjjm 5951 17 CLM CLM NNP cord-023095-4dannjjm 5951 18 , , , cord-023095-4dannjjm 5951 19 to to TO cord-023095-4dannjjm 5951 20 identify identify VB cord-023095-4dannjjm 5951 21 thermal thermal JJ cord-023095-4dannjjm 5951 22 imaging imaging NN cord-023095-4dannjjm 5951 23 patterns pattern NNS cord-023095-4dannjjm 5951 24 for for IN cord-023095-4dannjjm 5951 25 various various JJ cord-023095-4dannjjm 5951 26 regions region NNS cord-023095-4dannjjm 5951 27 of of IN cord-023095-4dannjjm 5951 28 interest interest NN cord-023095-4dannjjm 5951 29 ( ( -LRB- cord-023095-4dannjjm 5951 30 ROI ROI NNP cord-023095-4dannjjm 5951 31 ) ) -RRB- cord-023095-4dannjjm 5951 32 , , , cord-023095-4dannjjm 5951 33 to to TO cord-023095-4dannjjm 5951 34 evaluate evaluate VB cord-023095-4dannjjm 5951 35 changes change NNS cord-023095-4dannjjm 5951 36 in in IN cord-023095-4dannjjm 5951 37 thermal thermal JJ cord-023095-4dannjjm 5951 38 patterns pattern NNS cord-023095-4dannjjm 5951 39 and and CC cord-023095-4dannjjm 5951 40 compare compare VBP cord-023095-4dannjjm 5951 41 the the DT cord-023095-4dannjjm 5951 42 results result NNS cord-023095-4dannjjm 5951 43 to to IN cord-023095-4dannjjm 5951 44 those those DT cord-023095-4dannjjm 5951 45 of of IN cord-023095-4dannjjm 5951 46 MRI MRI NNP cord-023095-4dannjjm 5951 47 findings finding NNS cord-023095-4dannjjm 5951 48 , , , cord-023095-4dannjjm 5951 49 considered consider VBD cord-023095-4dannjjm 5951 50 the the DT cord-023095-4dannjjm 5951 51 standard standard NN cord-023095-4dannjjm 5951 52 for for IN cord-023095-4dannjjm 5951 53 diagnosing diagnose VBG cord-023095-4dannjjm 5951 54 CLM CLM NNP cord-023095-4dannjjm 5951 55 in in IN cord-023095-4dannjjm 5951 56 dogs dog NNS cord-023095-4dannjjm 5951 57 . . . cord-023095-4dannjjm 5952 1 One one CD cord-023095-4dannjjm 5952 2 hundred hundred CD cord-023095-4dannjjm 5952 3 and and CC cord-023095-4dannjjm 5952 4 five five CD cord-023095-4dannjjm 5952 5 Cavalier Cavalier NNP cord-023095-4dannjjm 5952 6 King King NNP cord-023095-4dannjjm 5952 7 Charles Charles NNP cord-023095-4dannjjm 5952 8 Spaniel Spaniel NNP cord-023095-4dannjjm 5952 9 dogs dog NNS cord-023095-4dannjjm 5952 10 with with IN cord-023095-4dannjjm 5952 11 clinical clinical JJ cord-023095-4dannjjm 5952 12 signs sign NNS cord-023095-4dannjjm 5952 13 attributable attributable JJ cord-023095-4dannjjm 5952 14 to to IN cord-023095-4dannjjm 5952 15 CLM CLM NNP cord-023095-4dannjjm 5952 16 and and CC cord-023095-4dannjjm 5952 17 confirmed confirm VBD cord-023095-4dannjjm 5952 18 CLM CLM NNP cord-023095-4dannjjm 5952 19 with with IN cord-023095-4dannjjm 5952 20 MRI MRI NNP cord-023095-4dannjjm 5952 21 were be VBD cord-023095-4dannjjm 5952 22 evaluated evaluate VBN cord-023095-4dannjjm 5952 23 with with IN cord-023095-4dannjjm 5952 24 a a DT cord-023095-4dannjjm 5952 25 complete complete JJ cord-023095-4dannjjm 5952 26 blood blood NN cord-023095-4dannjjm 5952 27 count count NN cord-023095-4dannjjm 5952 28 and and CC cord-023095-4dannjjm 5952 29 chemistry chemistry NN cord-023095-4dannjjm 5952 30 profile profile NN cord-023095-4dannjjm 5952 31 , , , cord-023095-4dannjjm 5952 32 examination examination NN cord-023095-4dannjjm 5952 33 by by IN cord-023095-4dannjjm 5952 34 a a DT cord-023095-4dannjjm 5952 35 board board NN cord-023095-4dannjjm 5952 36 certified certify VBN cord-023095-4dannjjm 5952 37 surgeon surgeon NN cord-023095-4dannjjm 5952 38 / / SYM cord-023095-4dannjjm 5952 39 neurologist neurologist NN cord-023095-4dannjjm 5952 40 , , , cord-023095-4dannjjm 5952 41 multidetector multidetector NN cord-023095-4dannjjm 5952 42 CT CT NNP cord-023095-4dannjjm 5952 43 scan scan NN cord-023095-4dannjjm 5952 44 of of IN cord-023095-4dannjjm 5952 45 the the DT cord-023095-4dannjjm 5952 46 craniocervical craniocervical NNP cord-023095-4dannjjm 5952 47 junction junction NN cord-023095-4dannjjm 5952 48 , , , cord-023095-4dannjjm 5952 49 whole whole JJ cord-023095-4dannjjm 5952 50 body body NN cord-023095-4dannjjm 5952 51 MRI MRI NNP cord-023095-4dannjjm 5952 52 and and CC cord-023095-4dannjjm 5952 53 MII MII NNP cord-023095-4dannjjm 5952 54 . . . cord-023095-4dannjjm 5953 1 The the DT cord-023095-4dannjjm 5953 2 protocol protocol NN cord-023095-4dannjjm 5953 3 for for IN cord-023095-4dannjjm 5953 4 thermal thermal JJ cord-023095-4dannjjm 5953 5 imaging imaging NN cord-023095-4dannjjm 5953 6 included include VBD cord-023095-4dannjjm 5953 7 cranial cranial JJ cord-023095-4dannjjm 5953 8 and and CC cord-023095-4dannjjm 5953 9 caudal caudal JJ cord-023095-4dannjjm 5953 10 views view NNS cord-023095-4dannjjm 5953 11 of of IN cord-023095-4dannjjm 5953 12 the the DT cord-023095-4dannjjm 5953 13 body body NN cord-023095-4dannjjm 5953 14 , , , cord-023095-4dannjjm 5953 15 full full JJ cord-023095-4dannjjm 5953 16 lateral lateral JJ cord-023095-4dannjjm 5953 17 right right NN cord-023095-4dannjjm 5953 18 and and CC cord-023095-4dannjjm 5953 19 left left JJ cord-023095-4dannjjm 5953 20 body body NN cord-023095-4dannjjm 5953 21 views view NNS cord-023095-4dannjjm 5953 22 , , , cord-023095-4dannjjm 5953 23 dorsal dorsal JJ cord-023095-4dannjjm 5953 24 views view NNS cord-023095-4dannjjm 5953 25 of of IN cord-023095-4dannjjm 5953 26 the the DT cord-023095-4dannjjm 5953 27 head head NN cord-023095-4dannjjm 5953 28 and and CC cord-023095-4dannjjm 5953 29 body body NN cord-023095-4dannjjm 5953 30 , , , cord-023095-4dannjjm 5953 31 and and CC cord-023095-4dannjjm 5953 32 right right UH cord-023095-4dannjjm 5953 33 and and CC cord-023095-4dannjjm 5953 34 left leave VBD cord-023095-4dannjjm 5953 35 lateral lateral JJ cord-023095-4dannjjm 5953 36 views view NNS cord-023095-4dannjjm 5953 37 of of IN cord-023095-4dannjjm 5953 38 the the DT cord-023095-4dannjjm 5953 39 head head NN cord-023095-4dannjjm 5953 40 . . . cord-023095-4dannjjm 5954 1 Thermal thermal JJ cord-023095-4dannjjm 5954 2 patterns pattern NNS cord-023095-4dannjjm 5954 3 were be VBD cord-023095-4dannjjm 5954 4 assessed assess VBN cord-023095-4dannjjm 5954 5 with with IN cord-023095-4dannjjm 5954 6 custom custom NN cord-023095-4dannjjm 5954 7 image image NN cord-023095-4dannjjm 5954 8 recognition recognition NN cord-023095-4dannjjm 5954 9 software software NN cord-023095-4dannjjm 5954 10 . . . cord-023095-4dannjjm 5955 1 After after IN cord-023095-4dannjjm 5955 2 each each DT cord-023095-4dannjjm 5955 3 dog dog NN cord-023095-4dannjjm 5955 4 was be VBD cord-023095-4dannjjm 5955 5 imaged image VBN cord-023095-4dannjjm 5955 6 awake awake JJ cord-023095-4dannjjm 5955 7 , , , cord-023095-4dannjjm 5955 8 general general JJ cord-023095-4dannjjm 5955 9 anesthesia anesthesia NN cord-023095-4dannjjm 5955 10 was be VBD cord-023095-4dannjjm 5955 11 administered administer VBN cord-023095-4dannjjm 5955 12 and and CC cord-023095-4dannjjm 5955 13 the the DT cord-023095-4dannjjm 5955 14 dogs dog NNS cord-023095-4dannjjm 5955 15 re re VBP cord-023095-4dannjjm 5955 16 - - VBD cord-023095-4dannjjm 5955 17 imaged image VBD cord-023095-4dannjjm 5955 18 using use VBG cord-023095-4dannjjm 5955 19 the the DT cord-023095-4dannjjm 5955 20 same same JJ cord-023095-4dannjjm 5955 21 protocol protocol NN cord-023095-4dannjjm 5955 22 . . . cord-023095-4dannjjm 5956 1 MRI MRI NNP cord-023095-4dannjjm 5956 2 findings finding NNS cord-023095-4dannjjm 5956 3 in in IN cord-023095-4dannjjm 5956 4 dogs dog NNS cord-023095-4dannjjm 5956 5 with with IN cord-023095-4dannjjm 5956 6 severe severe JJ cord-023095-4dannjjm 5956 7 or or CC cord-023095-4dannjjm 5956 8 moderate moderate JJ cord-023095-4dannjjm 5956 9 cerebellar cerebellar JJ cord-023095-4dannjjm 5956 10 compression compression NN cord-023095-4dannjjm 5956 11 and and CC cord-023095-4dannjjm 5956 12 cerebellar cerebellar JJ cord-023095-4dannjjm 5956 13 herniation herniation NN cord-023095-4dannjjm 5956 14 were be VBD cord-023095-4dannjjm 5956 15 compared compare VBN cord-023095-4dannjjm 5956 16 with with IN cord-023095-4dannjjm 5956 17 MII MII NNP cord-023095-4dannjjm 5956 18 results result NNS cord-023095-4dannjjm 5956 19 . . . cord-023095-4dannjjm 5957 1 The the DT cord-023095-4dannjjm 5957 2 top top NN cord-023095-4dannjjm 5957 3 of of IN cord-023095-4dannjjm 5957 4 head head NN cord-023095-4dannjjm 5957 5 and and CC cord-023095-4dannjjm 5957 6 front front NN cord-023095-4dannjjm 5957 7 of of IN cord-023095-4dannjjm 5957 8 head head NN cord-023095-4dannjjm 5957 9 ROI ROI NNP cord-023095-4dannjjm 5957 10 were be VBD cord-023095-4dannjjm 5957 11 89.2 89.2 CD cord-023095-4dannjjm 5957 12 % % NN cord-023095-4dannjjm 5957 13 and and CC cord-023095-4dannjjm 5957 14 97.3 97.3 CD cord-023095-4dannjjm 5957 15 % % NN cord-023095-4dannjjm 5957 16 successful successful JJ cord-023095-4dannjjm 5957 17 in in IN cord-023095-4dannjjm 5957 18 identifying identify VBG cord-023095-4dannjjm 5957 19 dogs dog NNS cord-023095-4dannjjm 5957 20 with with IN cord-023095-4dannjjm 5957 21 CLM CLM NNP cord-023095-4dannjjm 5957 22 . . . cord-023095-4dannjjm 5958 1 Based base VBN cord-023095-4dannjjm 5958 2 on on IN cord-023095-4dannjjm 5958 3 these these DT cord-023095-4dannjjm 5958 4 preliminary preliminary JJ cord-023095-4dannjjm 5958 5 findings finding NNS cord-023095-4dannjjm 5958 6 , , , cord-023095-4dannjjm 5958 7 MII MII NNP cord-023095-4dannjjm 5958 8 may may MD cord-023095-4dannjjm 5958 9 be be VB cord-023095-4dannjjm 5958 10 a a DT cord-023095-4dannjjm 5958 11 viable viable JJ cord-023095-4dannjjm 5958 12 screening screening NN cord-023095-4dannjjm 5958 13 tool tool NN cord-023095-4dannjjm 5958 14 to to TO cord-023095-4dannjjm 5958 15 detect detect VB cord-023095-4dannjjm 5958 16 CLM CLM NNP cord-023095-4dannjjm 5958 17 in in IN cord-023095-4dannjjm 5958 18 dogs dog NNS cord-023095-4dannjjm 5958 19 . . . cord-023095-4dannjjm 5959 1 Medical medical JJ cord-023095-4dannjjm 5959 2 infrared infrared JJ cord-023095-4dannjjm 5959 3 imaging imaging NN cord-023095-4dannjjm 5959 4 ( ( -LRB- cord-023095-4dannjjm 5959 5 MII MII NNP cord-023095-4dannjjm 5959 6 ) ) -RRB- cord-023095-4dannjjm 5959 7 is be VBZ cord-023095-4dannjjm 5959 8 an an DT cord-023095-4dannjjm 5959 9 imaging imaging NN cord-023095-4dannjjm 5959 10 technique technique NN cord-023095-4dannjjm 5959 11 that that WDT cord-023095-4dannjjm 5959 12 measures measure VBZ cord-023095-4dannjjm 5959 13 skin skin NN cord-023095-4dannjjm 5959 14 surface surface NN cord-023095-4dannjjm 5959 15 temperature temperature NN cord-023095-4dannjjm 5959 16 derived derive VBN cord-023095-4dannjjm 5959 17 from from IN cord-023095-4dannjjm 5959 18 cutaneous cutaneous JJ cord-023095-4dannjjm 5959 19 perfusion perfusion NN cord-023095-4dannjjm 5959 20 and and CC cord-023095-4dannjjm 5959 21 generates generate VBZ cord-023095-4dannjjm 5959 22 thermal thermal JJ cord-023095-4dannjjm 5959 23 pattern pattern NN cord-023095-4dannjjm 5959 24 maps map NNS cord-023095-4dannjjm 5959 25 based base VBN cord-023095-4dannjjm 5959 26 on on IN cord-023095-4dannjjm 5959 27 color color NN cord-023095-4dannjjm 5959 28 scales scale NNS cord-023095-4dannjjm 5959 29 . . . cord-023095-4dannjjm 5960 1 MII MII NNP cord-023095-4dannjjm 5960 2 has have VBZ cord-023095-4dannjjm 5960 3 been be VBN cord-023095-4dannjjm 5960 4 used use VBN cord-023095-4dannjjm 5960 5 as as IN cord-023095-4dannjjm 5960 6 a a DT cord-023095-4dannjjm 5960 7 test test NN cord-023095-4dannjjm 5960 8 for for IN cord-023095-4dannjjm 5960 9 a a DT cord-023095-4dannjjm 5960 10 variety variety NN cord-023095-4dannjjm 5960 11 of of IN cord-023095-4dannjjm 5960 12 conditions condition NNS cord-023095-4dannjjm 5960 13 that that WDT cord-023095-4dannjjm 5960 14 cause cause VBP cord-023095-4dannjjm 5960 15 autonomic autonomic JJ cord-023095-4dannjjm 5960 16 dysregulation dysregulation NN cord-023095-4dannjjm 5960 17 resulting result VBG cord-023095-4dannjjm 5960 18 in in IN cord-023095-4dannjjm 5960 19 altered alter VBN cord-023095-4dannjjm 5960 20 cutaneous cutaneous JJ cord-023095-4dannjjm 5960 21 perfusion perfusion NN cord-023095-4dannjjm 5960 22 . . . cord-023095-4dannjjm 5961 1 Acute acute JJ cord-023095-4dannjjm 5961 2 thoracolumbar thoracolumbar RB cord-023095-4dannjjm 5961 3 intervertebral intervertebral JJ cord-023095-4dannjjm 5961 4 disk disk NN cord-023095-4dannjjm 5961 5 disease disease NN cord-023095-4dannjjm 5961 6 ( ( -LRB- cord-023095-4dannjjm 5961 7 TLIVDD TLIVDD NNP cord-023095-4dannjjm 5961 8 ) ) -RRB- cord-023095-4dannjjm 5961 9 is be VBZ cord-023095-4dannjjm 5961 10 common common JJ cord-023095-4dannjjm 5961 11 in in IN cord-023095-4dannjjm 5961 12 dogs dog NNS cord-023095-4dannjjm 5961 13 . . . cord-023095-4dannjjm 5962 1 The the DT cord-023095-4dannjjm 5962 2 purpose purpose NN cord-023095-4dannjjm 5962 3 of of IN cord-023095-4dannjjm 5962 4 this this DT cord-023095-4dannjjm 5962 5 study study NN cord-023095-4dannjjm 5962 6 was be VBD cord-023095-4dannjjm 5962 7 to to IN cord-023095-4dannjjm 5962 8 : : : cord-023095-4dannjjm 5962 9 1 1 LS cord-023095-4dannjjm 5962 10 ) ) -RRB- cord-023095-4dannjjm 5962 11 determine determine VB cord-023095-4dannjjm 5962 12 the the DT cord-023095-4dannjjm 5962 13 success success NN cord-023095-4dannjjm 5962 14 of of IN cord-023095-4dannjjm 5962 15 MII MII NNP cord-023095-4dannjjm 5962 16 in in IN cord-023095-4dannjjm 5962 17 identifying identify VBG cord-023095-4dannjjm 5962 18 dogs dog NNS cord-023095-4dannjjm 5962 19 with with IN cord-023095-4dannjjm 5962 20 TLIVDD TLIVDD NNP cord-023095-4dannjjm 5962 21 , , , cord-023095-4dannjjm 5962 22 2 2 CD cord-023095-4dannjjm 5962 23 ) ) -RRB- cord-023095-4dannjjm 5962 24 compare compare VBP cord-023095-4dannjjm 5962 25 the the DT cord-023095-4dannjjm 5962 26 MII MII NNP cord-023095-4dannjjm 5962 27 localization localization NN cord-023095-4dannjjm 5962 28 with with IN cord-023095-4dannjjm 5962 29 MRI MRI NNP cord-023095-4dannjjm 5962 30 results result NNS cord-023095-4dannjjm 5962 31 and and CC cord-023095-4dannjjm 5962 32 surgical surgical JJ cord-023095-4dannjjm 5962 33 findings finding NNS cord-023095-4dannjjm 5962 34 3 3 CD cord-023095-4dannjjm 5962 35 ) ) -RRB- cord-023095-4dannjjm 5962 36 determine determine VB cord-023095-4dannjjm 5962 37 if if IN cord-023095-4dannjjm 5962 38 the the DT cord-023095-4dannjjm 5962 39 MII MII NNP cord-023095-4dannjjm 5962 40 pattern pattern NN cord-023095-4dannjjm 5962 41 returns return VBZ cord-023095-4dannjjm 5962 42 to to IN cord-023095-4dannjjm 5962 43 that that DT cord-023095-4dannjjm 5962 44 of of IN cord-023095-4dannjjm 5962 45 normal normal JJ cord-023095-4dannjjm 5962 46 dogs dog NNS cord-023095-4dannjjm 5962 47 following follow VBG cord-023095-4dannjjm 5962 48 decompression decompression NN cord-023095-4dannjjm 5962 49 surgery surgery NN cord-023095-4dannjjm 5962 50 . . . cord-023095-4dannjjm 5963 1 72 72 CD cord-023095-4dannjjm 5963 2 small small JJ cord-023095-4dannjjm 5963 3 breed breed NN cord-023095-4dannjjm 5963 4 chondodystrophic chondodystrophic JJ cord-023095-4dannjjm 5963 5 dogs dog NNS cord-023095-4dannjjm 5963 6 with with IN cord-023095-4dannjjm 5963 7 TLIVDD TLIVDD NNP cord-023095-4dannjjm 5963 8 confirmed confirm VBD cord-023095-4dannjjm 5963 9 with with IN cord-023095-4dannjjm 5963 10 MRI MRI NNP cord-023095-4dannjjm 5963 11 and and CC cord-023095-4dannjjm 5963 12 14 14 CD cord-023095-4dannjjm 5963 13 dogs dog NNS cord-023095-4dannjjm 5963 14 with with IN cord-023095-4dannjjm 5963 15 no no DT cord-023095-4dannjjm 5963 16 TLIVDD TLIVDD NNP cord-023095-4dannjjm 5963 17 were be VBD cord-023095-4dannjjm 5963 18 evaluated evaluate VBN cord-023095-4dannjjm 5963 19 with with IN cord-023095-4dannjjm 5963 20 MRI MRI NNP cord-023095-4dannjjm 5963 21 and and CC cord-023095-4dannjjm 5963 22 MII MII NNP cord-023095-4dannjjm 5963 23 . . . cord-023095-4dannjjm 5964 1 Regions region NNS cord-023095-4dannjjm 5964 2 correlating correlate VBG cord-023095-4dannjjm 5964 3 with with IN cord-023095-4dannjjm 5964 4 the the DT cord-023095-4dannjjm 5964 5 intervertebral intervertebral JJ cord-023095-4dannjjm 5964 6 disk disk NN cord-023095-4dannjjm 5964 7 spaces space NNS cord-023095-4dannjjm 5964 8 were be VBD cord-023095-4dannjjm 5964 9 analyzed analyze VBN cord-023095-4dannjjm 5964 10 for for IN cord-023095-4dannjjm 5964 11 average average JJ cord-023095-4dannjjm 5964 12 temperatures temperature NNS cord-023095-4dannjjm 5964 13 and and CC cord-023095-4dannjjm 5964 14 thermographic thermographic JJ cord-023095-4dannjjm 5964 15 patterns pattern NNS cord-023095-4dannjjm 5964 16 . . . cord-023095-4dannjjm 5965 1 Thermal thermal JJ cord-023095-4dannjjm 5965 2 patterns pattern NNS cord-023095-4dannjjm 5965 3 were be VBD cord-023095-4dannjjm 5965 4 assessed assess VBN cord-023095-4dannjjm 5965 5 with with IN cord-023095-4dannjjm 5965 6 computer computer NN cord-023095-4dannjjm 5965 7 recognition recognition NN cord-023095-4dannjjm 5965 8 pattern pattern NN cord-023095-4dannjjm 5965 9 analysis analysis NN cord-023095-4dannjjm 5965 10 ( ( -LRB- cord-023095-4dannjjm 5965 11 CRPA CRPA NNP cord-023095-4dannjjm 5965 12 ) ) -RRB- cord-023095-4dannjjm 5965 13 software software NN cord-023095-4dannjjm 5965 14 . . . cord-023095-4dannjjm 5966 1 21 21 CD cord-023095-4dannjjm 5966 2 dogs dog NNS cord-023095-4dannjjm 5966 3 were be VBD cord-023095-4dannjjm 5966 4 re re VBN cord-023095-4dannjjm 5966 5 - - VBN cord-023095-4dannjjm 5966 6 evaluated evaluate VBN cord-023095-4dannjjm 5966 7 8 8 CD cord-023095-4dannjjm 5966 8 weeks week NNS cord-023095-4dannjjm 5966 9 after after IN cord-023095-4dannjjm 5966 10 surgery surgery NN cord-023095-4dannjjm 5966 11 using use VBG cord-023095-4dannjjm 5966 12 the the DT cord-023095-4dannjjm 5966 13 same same JJ cord-023095-4dannjjm 5966 14 protocol protocol NN cord-023095-4dannjjm 5966 15 . . . cord-023095-4dannjjm 5967 1 When when WRB cord-023095-4dannjjm 5967 2 analyzing analyze VBG cord-023095-4dannjjm 5967 3 temperature temperature NN cord-023095-4dannjjm 5967 4 averages average NNS cord-023095-4dannjjm 5967 5 over over IN cord-023095-4dannjjm 5967 6 a a DT cord-023095-4dannjjm 5967 7 region region NN cord-023095-4dannjjm 5967 8 , , , cord-023095-4dannjjm 5967 9 no no DT cord-023095-4dannjjm 5967 10 significant significant JJ cord-023095-4dannjjm 5967 11 difference difference NN cord-023095-4dannjjm 5967 12 was be VBD cord-023095-4dannjjm 5967 13 found find VBN cord-023095-4dannjjm 5967 14 between between IN cord-023095-4dannjjm 5967 15 control control NN cord-023095-4dannjjm 5967 16 and and CC cord-023095-4dannjjm 5967 17 affected affect VBN cord-023095-4dannjjm 5967 18 dogs dog NNS cord-023095-4dannjjm 5967 19 . . . cord-023095-4dannjjm 5968 1 CRPA CRPA NNP cord-023095-4dannjjm 5968 2 was be VBD cord-023095-4dannjjm 5968 3 90 90 CD cord-023095-4dannjjm 5968 4 % % NN cord-023095-4dannjjm 5968 5 successful successful JJ cord-023095-4dannjjm 5968 6 in in IN cord-023095-4dannjjm 5968 7 differentiating differentiate VBG cord-023095-4dannjjm 5968 8 normal normal JJ cord-023095-4dannjjm 5968 9 from from IN cord-023095-4dannjjm 5968 10 affected affected JJ cord-023095-4dannjjm 5968 11 dogs dog NNS cord-023095-4dannjjm 5968 12 . . . cord-023095-4dannjjm 5969 1 CRPA CRPA NNP cord-023095-4dannjjm 5969 2 was be VBD cord-023095-4dannjjm 5969 3 97 97 CD cord-023095-4dannjjm 5969 4 % % NN cord-023095-4dannjjm 5969 5 successful successful JJ cord-023095-4dannjjm 5969 6 in in IN cord-023095-4dannjjm 5969 7 identifying identify VBG cord-023095-4dannjjm 5969 8 the the DT cord-023095-4dannjjm 5969 9 intervertebral intervertebral JJ cord-023095-4dannjjm 5969 10 disk disk NN cord-023095-4dannjjm 5969 11 space space NN cord-023095-4dannjjm 5969 12 when when WRB cord-023095-4dannjjm 5969 13 compared compare VBN cord-023095-4dannjjm 5969 14 with with IN cord-023095-4dannjjm 5969 15 MRI MRI NNP cord-023095-4dannjjm 5969 16 and and CC cord-023095-4dannjjm 5969 17 surgical surgical JJ cord-023095-4dannjjm 5969 18 findings finding NNS cord-023095-4dannjjm 5969 19 . . . cord-023095-4dannjjm 5970 1 Based base VBN cord-023095-4dannjjm 5970 2 on on IN cord-023095-4dannjjm 5970 3 these these DT cord-023095-4dannjjm 5970 4 findings finding NNS cord-023095-4dannjjm 5970 5 , , , cord-023095-4dannjjm 5970 6 MII MII NNP cord-023095-4dannjjm 5970 7 may may MD cord-023095-4dannjjm 5970 8 be be VB cord-023095-4dannjjm 5970 9 a a DT cord-023095-4dannjjm 5970 10 viable viable JJ cord-023095-4dannjjm 5970 11 screening screening NN cord-023095-4dannjjm 5970 12 tool tool NN cord-023095-4dannjjm 5970 13 to to TO cord-023095-4dannjjm 5970 14 detect detect VB cord-023095-4dannjjm 5970 15 TLIVDD TLIVDD NNP cord-023095-4dannjjm 5970 16 in in IN cord-023095-4dannjjm 5970 17 dogs dog NNS cord-023095-4dannjjm 5970 18 . . . cord-023095-4dannjjm 5971 1 Microglia Microglia NNP cord-023095-4dannjjm 5971 2 physiologically physiologically RB cord-023095-4dannjjm 5971 3 shows show VBZ cord-023095-4dannjjm 5971 4 regional regional JJ cord-023095-4dannjjm 5971 5 topographical topographical JJ cord-023095-4dannjjm 5971 6 differences difference NNS cord-023095-4dannjjm 5971 7 in in IN cord-023095-4dannjjm 5971 8 immunophenotype immunophenotype NN cord-023095-4dannjjm 5971 9 and and CC cord-023095-4dannjjm 5971 10 function function VB cord-023095-4dannjjm 5971 11 within within IN cord-023095-4dannjjm 5971 12 the the DT cord-023095-4dannjjm 5971 13 central central JJ cord-023095-4dannjjm 5971 14 nervous nervous JJ cord-023095-4dannjjm 5971 15 system system NN cord-023095-4dannjjm 5971 16 indicating indicate VBG cord-023095-4dannjjm 5971 17 the the DT cord-023095-4dannjjm 5971 18 endowment endowment NN cord-023095-4dannjjm 5971 19 for for IN cord-023095-4dannjjm 5971 20 a a DT cord-023095-4dannjjm 5971 21 prompt prompt JJ cord-023095-4dannjjm 5971 22 response response NN cord-023095-4dannjjm 5971 23 to to IN cord-023095-4dannjjm 5971 24 pathological pathological JJ cord-023095-4dannjjm 5971 25 stimuli stimulus NNS cord-023095-4dannjjm 5971 26 such such JJ cord-023095-4dannjjm 5971 27 as as IN cord-023095-4dannjjm 5971 28 trauma trauma NN cord-023095-4dannjjm 5971 29 . . . cord-023095-4dannjjm 5972 1 Spinal spinal JJ cord-023095-4dannjjm 5972 2 cord cord NN cord-023095-4dannjjm 5972 3 injuries injury NNS cord-023095-4dannjjm 5972 4 ( ( -LRB- cord-023095-4dannjjm 5972 5 SCI SCI NNP cord-023095-4dannjjm 5972 6 ) ) -RRB- cord-023095-4dannjjm 5972 7 consist consist VBP cord-023095-4dannjjm 5972 8 of of IN cord-023095-4dannjjm 5972 9 a a DT cord-023095-4dannjjm 5972 10 primary primary JJ cord-023095-4dannjjm 5972 11 injury injury NN cord-023095-4dannjjm 5972 12 encompassing encompass VBG cord-023095-4dannjjm 5972 13 the the DT cord-023095-4dannjjm 5972 14 mechanical mechanical JJ cord-023095-4dannjjm 5972 15 impact impact NN cord-023095-4dannjjm 5972 16 and and CC cord-023095-4dannjjm 5972 17 the the DT cord-023095-4dannjjm 5972 18 ' ' `` cord-023095-4dannjjm 5972 19 ' ' `` cord-023095-4dannjjm 5972 20 secondary secondary JJ cord-023095-4dannjjm 5972 21 wave wave NN cord-023095-4dannjjm 5972 22 ' ' '' cord-023095-4dannjjm 5972 23 ' ' '' cord-023095-4dannjjm 5972 24 of of IN cord-023095-4dannjjm 5972 25 injury injury NN cord-023095-4dannjjm 5972 26 occurring occur VBG cord-023095-4dannjjm 5972 27 minutes minute NNS cord-023095-4dannjjm 5972 28 to to IN cord-023095-4dannjjm 5972 29 weeks week NNS cord-023095-4dannjjm 5972 30 later later RB cord-023095-4dannjjm 5972 31 and and CC cord-023095-4dannjjm 5972 32 comprising comprise VBG cord-023095-4dannjjm 5972 33 various various JJ cord-023095-4dannjjm 5972 34 consecutive consecutive JJ cord-023095-4dannjjm 5972 35 effects effect NNS cord-023095-4dannjjm 5972 36 such such JJ cord-023095-4dannjjm 5972 37 as as IN cord-023095-4dannjjm 5972 38 increased increase VBN cord-023095-4dannjjm 5972 39 production production NN cord-023095-4dannjjm 5972 40 of of IN cord-023095-4dannjjm 5972 41 free free JJ cord-023095-4dannjjm 5972 42 radicals radical NNS cord-023095-4dannjjm 5972 43 , , , cord-023095-4dannjjm 5972 44 excessive excessive JJ cord-023095-4dannjjm 5972 45 release release NN cord-023095-4dannjjm 5972 46 of of IN cord-023095-4dannjjm 5972 47 excitatory excitatory JJ cord-023095-4dannjjm 5972 48 neurotransmitters neurotransmitter NNS cord-023095-4dannjjm 5972 49 and and CC cord-023095-4dannjjm 5972 50 inflammatory inflammatory JJ cord-023095-4dannjjm 5972 51 reactions reaction NNS cord-023095-4dannjjm 5972 52 . . . cord-023095-4dannjjm 5973 1 Activated activate VBN cord-023095-4dannjjm 5973 2 microglia microglia NNS cord-023095-4dannjjm 5973 3 has have VBZ cord-023095-4dannjjm 5973 4 the the DT cord-023095-4dannjjm 5973 5 potential potential NN cord-023095-4dannjjm 5973 6 to to TO cord-023095-4dannjjm 5973 7 perform perform VB cord-023095-4dannjjm 5973 8 some some DT cord-023095-4dannjjm 5973 9 of of IN cord-023095-4dannjjm 5973 10 these these DT cord-023095-4dannjjm 5973 11 reactions reaction NNS cord-023095-4dannjjm 5973 12 , , , cord-023095-4dannjjm 5973 13 their -PRON- PRP$ cord-023095-4dannjjm 5973 14 contribution contribution NN cord-023095-4dannjjm 5973 15 to to IN cord-023095-4dannjjm 5973 16 the the DT cord-023095-4dannjjm 5973 17 secondary secondary JJ cord-023095-4dannjjm 5973 18 wave wave NN cord-023095-4dannjjm 5973 19 is be VBZ cord-023095-4dannjjm 5973 20 therefore therefore RB cord-023095-4dannjjm 5973 21 controversially controversially RB cord-023095-4dannjjm 5973 22 discussed discuss VBN cord-023095-4dannjjm 5973 23 . . . cord-023095-4dannjjm 5974 1 It -PRON- PRP cord-023095-4dannjjm 5974 2 has have VBZ cord-023095-4dannjjm 5974 3 to to TO cord-023095-4dannjjm 5974 4 be be VB cord-023095-4dannjjm 5974 5 considered consider VBN cord-023095-4dannjjm 5974 6 a a DT cord-023095-4dannjjm 5974 7 double double RB cord-023095-4dannjjm 5974 8 - - HYPH cord-023095-4dannjjm 5974 9 edged edged JJ cord-023095-4dannjjm 5974 10 sword sword NN cord-023095-4dannjjm 5974 11 as as IN cord-023095-4dannjjm 5974 12 both both DT cord-023095-4dannjjm 5974 13 , , , cord-023095-4dannjjm 5974 14 beneficial beneficial JJ cord-023095-4dannjjm 5974 15 and and CC cord-023095-4dannjjm 5974 16 deleterious deleterious JJ cord-023095-4dannjjm 5974 17 effects effect NNS cord-023095-4dannjjm 5974 18 have have VBP cord-023095-4dannjjm 5974 19 been be VBN cord-023095-4dannjjm 5974 20 attributed attribute VBN cord-023095-4dannjjm 5974 21 to to IN cord-023095-4dannjjm 5974 22 these these DT cord-023095-4dannjjm 5974 23 cells cell NNS cord-023095-4dannjjm 5974 24 . . . cord-023095-4dannjjm 5975 1 The the DT cord-023095-4dannjjm 5975 2 purpose purpose NN cord-023095-4dannjjm 5975 3 of of IN cord-023095-4dannjjm 5975 4 the the DT cord-023095-4dannjjm 5975 5 presented present VBN cord-023095-4dannjjm 5975 6 study study NN cord-023095-4dannjjm 5975 7 was be VBD cord-023095-4dannjjm 5975 8 to to TO cord-023095-4dannjjm 5975 9 assess assess VB cord-023095-4dannjjm 5975 10 microglial microglial JJ cord-023095-4dannjjm 5975 11 involvement involvement NN cord-023095-4dannjjm 5975 12 , , , cord-023095-4dannjjm 5975 13 particularly particularly RB cord-023095-4dannjjm 5975 14 in in IN cord-023095-4dannjjm 5975 15 the the DT cord-023095-4dannjjm 5975 16 ' ' `` cord-023095-4dannjjm 5975 17 ' ' `` cord-023095-4dannjjm 5975 18 secondary secondary JJ cord-023095-4dannjjm 5975 19 wave wave NN cord-023095-4dannjjm 5975 20 ' ' '' cord-023095-4dannjjm 5975 21 ' ' '' cord-023095-4dannjjm 5975 22 following follow VBG cord-023095-4dannjjm 5975 23 SCI SCI NNP cord-023095-4dannjjm 5975 24 . . . cord-023095-4dannjjm 5976 1 Microglia Microglia NNP cord-023095-4dannjjm 5976 2 from from IN cord-023095-4dannjjm 5976 3 15 15 CD cord-023095-4dannjjm 5976 4 dogs dog NNS cord-023095-4dannjjm 5976 5 with with IN cord-023095-4dannjjm 5976 6 SCI SCI NNP cord-023095-4dannjjm 5976 7 was be VBD cord-023095-4dannjjm 5976 8 isolated isolate VBN cord-023095-4dannjjm 5976 9 and and CC cord-023095-4dannjjm 5976 10 characterized characterize VBN cord-023095-4dannjjm 5976 11 ex ex FW cord-023095-4dannjjm 5976 12 vivo vivo NN cord-023095-4dannjjm 5976 13 in in IN cord-023095-4dannjjm 5976 14 terms term NNS cord-023095-4dannjjm 5976 15 of of IN cord-023095-4dannjjm 5976 16 morphology morphology NN cord-023095-4dannjjm 5976 17 , , , cord-023095-4dannjjm 5976 18 immunophenotype immunophenotype NN cord-023095-4dannjjm 5976 19 , , , cord-023095-4dannjjm 5976 20 and and CC cord-023095-4dannjjm 5976 21 function function VB cord-023095-4dannjjm 5976 22 by by IN cord-023095-4dannjjm 5976 23 flow flow NN cord-023095-4dannjjm 5976 24 cytometry cytometry NN cord-023095-4dannjjm 5976 25 . . . cord-023095-4dannjjm 5977 1 The the DT cord-023095-4dannjjm 5977 2 results result NNS cord-023095-4dannjjm 5977 3 were be VBD cord-023095-4dannjjm 5977 4 compared compare VBN cord-023095-4dannjjm 5977 5 to to IN cord-023095-4dannjjm 5977 6 region region NN cord-023095-4dannjjm 5977 7 - - HYPH cord-023095-4dannjjm 5977 8 specific specific JJ cord-023095-4dannjjm 5977 9 findings finding NNS cord-023095-4dannjjm 5977 10 obtained obtain VBN cord-023095-4dannjjm 5977 11 from from IN cord-023095-4dannjjm 5977 12 healthy healthy JJ cord-023095-4dannjjm 5977 13 control control NN cord-023095-4dannjjm 5977 14 dogs dog NNS cord-023095-4dannjjm 5977 15 ( ( -LRB- cord-023095-4dannjjm 5977 16 n n NN cord-023095-4dannjjm 5977 17 5 5 CD cord-023095-4dannjjm 5977 18 30 30 CD cord-023095-4dannjjm 5977 19 ) ) -RRB- cord-023095-4dannjjm 5977 20 . . . cord-023095-4dannjjm 5978 1 The the DT cord-023095-4dannjjm 5978 2 histopathological histopathological JJ cord-023095-4dannjjm 5978 3 exam exam NN cord-023095-4dannjjm 5978 4 confirmed confirm VBD cord-023095-4dannjjm 5978 5 the the DT cord-023095-4dannjjm 5978 6 diagnosis diagnosis NN cord-023095-4dannjjm 5978 7 of of IN cord-023095-4dannjjm 5978 8 SCI SCI NNP cord-023095-4dannjjm 5978 9 in in IN cord-023095-4dannjjm 5978 10 the the DT cord-023095-4dannjjm 5978 11 cervical cervical NN cord-023095-4dannjjm 5978 12 ( ( -LRB- cord-023095-4dannjjm 5978 13 n n NN cord-023095-4dannjjm 5978 14 5 5 CD cord-023095-4dannjjm 5978 15 5 5 CD cord-023095-4dannjjm 5978 16 ) ) -RRB- cord-023095-4dannjjm 5978 17 and and CC cord-023095-4dannjjm 5978 18 thoracolumbar thoracolumbar NNP cord-023095-4dannjjm 5978 19 ( ( -LRB- cord-023095-4dannjjm 5978 20 n n NN cord-023095-4dannjjm 5978 21 5 5 CD cord-023095-4dannjjm 5978 22 10 10 CD cord-023095-4dannjjm 5978 23 ) ) -RRB- cord-023095-4dannjjm 5978 24 spinal spinal JJ cord-023095-4dannjjm 5978 25 cord cord NN cord-023095-4dannjjm 5978 26 , , , cord-023095-4dannjjm 5978 27 and and CC cord-023095-4dannjjm 5978 28 revealed reveal VBD cord-023095-4dannjjm 5978 29 a a DT cord-023095-4dannjjm 5978 30 significant significant JJ cord-023095-4dannjjm 5978 31 activation activation NN cord-023095-4dannjjm 5978 32 of of IN cord-023095-4dannjjm 5978 33 microglia/ microglia/ CD cord-023095-4dannjjm 5978 34 macrophages macrophage NNS cord-023095-4dannjjm 5978 35 and and CC cord-023095-4dannjjm 5978 36 upregulation upregulation NN cord-023095-4dannjjm 5978 37 of of IN cord-023095-4dannjjm 5978 38 myelinophagia myelinophagia NN cord-023095-4dannjjm 5978 39 in in IN cord-023095-4dannjjm 5978 40 dogs dog NNS cord-023095-4dannjjm 5978 41 with with IN cord-023095-4dannjjm 5978 42 SCI SCI NNP cord-023095-4dannjjm 5978 43 5 5 CD cord-023095-4dannjjm 5978 44 days day NNS cord-023095-4dannjjm 5978 45 or or CC cord-023095-4dannjjm 5978 46 longer long RBR cord-023095-4dannjjm 5978 47 prior prior RB cord-023095-4dannjjm 5978 48 to to IN cord-023095-4dannjjm 5978 49 euthanasia euthanasia NN cord-023095-4dannjjm 5978 50 . . . cord-023095-4dannjjm 5979 1 Microglial Microglial NNP cord-023095-4dannjjm 5979 2 ex ex NN cord-023095-4dannjjm 5979 3 vivo vivo NN cord-023095-4dannjjm 5979 4 examination examination NN cord-023095-4dannjjm 5979 5 showed show VBD cord-023095-4dannjjm 5979 6 significantly significantly RB cord-023095-4dannjjm 5979 7 increased increase VBN cord-023095-4dannjjm 5979 8 expressions expression NNS cord-023095-4dannjjm 5979 9 of of IN cord-023095-4dannjjm 5979 10 B7 b7 NN cord-023095-4dannjjm 5979 11 - - HYPH cord-023095-4dannjjm 5979 12 1 1 CD cord-023095-4dannjjm 5979 13 , , , cord-023095-4dannjjm 5979 14 B7 b7 NN cord-023095-4dannjjm 5979 15 - - HYPH cord-023095-4dannjjm 5979 16 2 2 CD cord-023095-4dannjjm 5979 17 , , , cord-023095-4dannjjm 5979 18 MHC MHC NNP cord-023095-4dannjjm 5979 19 II II NNP cord-023095-4dannjjm 5979 20 , , , cord-023095-4dannjjm 5979 21 CD1c CD1c NNP cord-023095-4dannjjm 5979 22 , , , cord-023095-4dannjjm 5979 23 ICAM-1 ICAM-1 NNP cord-023095-4dannjjm 5979 24 , , , cord-023095-4dannjjm 5979 25 CD14 CD14 NNP cord-023095-4dannjjm 5979 26 , , , cord-023095-4dannjjm 5979 27 CD44 CD44 NNP cord-023095-4dannjjm 5979 28 , , , cord-023095-4dannjjm 5979 29 and and CC cord-023095-4dannjjm 5979 30 CD45 CD45 NNP cord-023095-4dannjjm 5979 31 , , , cord-023095-4dannjjm 5979 32 and and CC cord-023095-4dannjjm 5979 33 significantly significantly RB cord-023095-4dannjjm 5979 34 enhanced enhance VBN cord-023095-4dannjjm 5979 35 phagocytosis phagocytosis NN cord-023095-4dannjjm 5979 36 and and CC cord-023095-4dannjjm 5979 37 generation generation NN cord-023095-4dannjjm 5979 38 of of IN cord-023095-4dannjjm 5979 39 reactive reactive JJ cord-023095-4dannjjm 5979 40 oxygen oxygen NN cord-023095-4dannjjm 5979 41 species specie NNS cord-023095-4dannjjm 5979 42 ( ( -LRB- cord-023095-4dannjjm 5979 43 ROS ROS NNP cord-023095-4dannjjm 5979 44 ) ) -RRB- cord-023095-4dannjjm 5979 45 in in IN cord-023095-4dannjjm 5979 46 SCI SCI NNP cord-023095-4dannjjm 5979 47 compared compare VBN cord-023095-4dannjjm 5979 48 to to IN cord-023095-4dannjjm 5979 49 healthy healthy JJ cord-023095-4dannjjm 5979 50 controls control NNS cord-023095-4dannjjm 5979 51 . . . cord-023095-4dannjjm 5980 1 Microglial microglial JJ cord-023095-4dannjjm 5980 2 cells cell NNS cord-023095-4dannjjm 5980 3 seem seem VBP cord-023095-4dannjjm 5980 4 to to TO cord-023095-4dannjjm 5980 5 be be VB cord-023095-4dannjjm 5980 6 highly highly RB cord-023095-4dannjjm 5980 7 activated activate VBN cord-023095-4dannjjm 5980 8 following follow VBG cord-023095-4dannjjm 5980 9 SCI SCI NNP cord-023095-4dannjjm 5980 10 with with IN cord-023095-4dannjjm 5980 11 an an DT cord-023095-4dannjjm 5980 12 immunophenotype immunophenotype NN cord-023095-4dannjjm 5980 13 indicating indicate VBG cord-023095-4dannjjm 5980 14 their -PRON- PRP$ cord-023095-4dannjjm 5980 15 active active JJ cord-023095-4dannjjm 5980 16 role role NN cord-023095-4dannjjm 5980 17 in in IN cord-023095-4dannjjm 5980 18 co co NN cord-023095-4dannjjm 5980 19 - - NN cord-023095-4dannjjm 5980 20 stimulation stimulation NN cord-023095-4dannjjm 5980 21 of of IN cord-023095-4dannjjm 5980 22 T t NN cord-023095-4dannjjm 5980 23 cells cell NNS cord-023095-4dannjjm 5980 24 , , , cord-023095-4dannjjm 5980 25 in in IN cord-023095-4dannjjm 5980 26 leukocyte leukocyte NN cord-023095-4dannjjm 5980 27 adhesion adhesion NN cord-023095-4dannjjm 5980 28 and and CC cord-023095-4dannjjm 5980 29 aggregation aggregation NN cord-023095-4dannjjm 5980 30 , , , cord-023095-4dannjjm 5980 31 and and CC cord-023095-4dannjjm 5980 32 in in IN cord-023095-4dannjjm 5980 33 lipid lipid NN cord-023095-4dannjjm 5980 34 and and CC cord-023095-4dannjjm 5980 35 glycolipid glycolipid NNP cord-023095-4dannjjm 5980 36 presentation presentation NN cord-023095-4dannjjm 5980 37 . . . cord-023095-4dannjjm 5981 1 Microglial microglial JJ cord-023095-4dannjjm 5981 2 phagocytosis phagocytosis NN cord-023095-4dannjjm 5981 3 might may MD cord-023095-4dannjjm 5981 4 play play VB cord-023095-4dannjjm 5981 5 a a DT cord-023095-4dannjjm 5981 6 pivotal pivotal JJ cord-023095-4dannjjm 5981 7 role role NN cord-023095-4dannjjm 5981 8 in in IN cord-023095-4dannjjm 5981 9 removal removal NN cord-023095-4dannjjm 5981 10 of of IN cord-023095-4dannjjm 5981 11 injured injure VBN cord-023095-4dannjjm 5981 12 or or CC cord-023095-4dannjjm 5981 13 damaged damage VBN cord-023095-4dannjjm 5981 14 cells cell NNS cord-023095-4dannjjm 5981 15 and and CC cord-023095-4dannjjm 5981 16 initialize initialize VB cord-023095-4dannjjm 5981 17 subsequent subsequent JJ cord-023095-4dannjjm 5981 18 healing healing NN cord-023095-4dannjjm 5981 19 processes process NNS cord-023095-4dannjjm 5981 20 . . . cord-023095-4dannjjm 5982 1 However however RB cord-023095-4dannjjm 5982 2 , , , cord-023095-4dannjjm 5982 3 as as IN cord-023095-4dannjjm 5982 4 ROS ROS NNP cord-023095-4dannjjm 5982 5 can can MD cord-023095-4dannjjm 5982 6 be be VB cord-023095-4dannjjm 5982 7 directly directly RB cord-023095-4dannjjm 5982 8 neurotoxic neurotoxic JJ cord-023095-4dannjjm 5982 9 an an DT cord-023095-4dannjjm 5982 10 enhanced enhanced JJ cord-023095-4dannjjm 5982 11 microglial microglial JJ cord-023095-4dannjjm 5982 12 generation generation NN cord-023095-4dannjjm 5982 13 might may MD cord-023095-4dannjjm 5982 14 lead lead VB cord-023095-4dannjjm 5982 15 to to IN cord-023095-4dannjjm 5982 16 bystander bystander NN cord-023095-4dannjjm 5982 17 damage damage NN cord-023095-4dannjjm 5982 18 of of IN cord-023095-4dannjjm 5982 19 the the DT cord-023095-4dannjjm 5982 20 traumatized traumatize VBN cord-023095-4dannjjm 5982 21 spinal spinal JJ cord-023095-4dannjjm 5982 22 cord cord NN cord-023095-4dannjjm 5982 23 and and CC cord-023095-4dannjjm 5982 24 might may MD cord-023095-4dannjjm 5982 25 therefore therefore RB cord-023095-4dannjjm 5982 26 add add VB cord-023095-4dannjjm 5982 27 to to IN cord-023095-4dannjjm 5982 28 the the DT cord-023095-4dannjjm 5982 29 deleterious deleterious JJ cord-023095-4dannjjm 5982 30 effects effect NNS cord-023095-4dannjjm 5982 31 of of IN cord-023095-4dannjjm 5982 32 the the DT cord-023095-4dannjjm 5982 33 secondary secondary JJ cord-023095-4dannjjm 5982 34 wave wave NN cord-023095-4dannjjm 5982 35 . . . cord-023095-4dannjjm 5983 1 Modulating modulate VBG cord-023095-4dannjjm 5983 2 the the DT cord-023095-4dannjjm 5983 3 microglial microglial JJ cord-023095-4dannjjm 5983 4 response response NN cord-023095-4dannjjm 5983 5 in in IN cord-023095-4dannjjm 5983 6 SCI SCI NNP cord-023095-4dannjjm 5983 7 might may MD cord-023095-4dannjjm 5983 8 be be VB cord-023095-4dannjjm 5983 9 a a DT cord-023095-4dannjjm 5983 10 valuable valuable JJ cord-023095-4dannjjm 5983 11 novel novel JJ cord-023095-4dannjjm 5983 12 therapeutic therapeutic JJ cord-023095-4dannjjm 5983 13 strategy strategy NN cord-023095-4dannjjm 5983 14 alleviating alleviate VBG cord-023095-4dannjjm 5983 15 further further JJ cord-023095-4dannjjm 5983 16 damage damage NN cord-023095-4dannjjm 5983 17 to to IN cord-023095-4dannjjm 5983 18 the the DT cord-023095-4dannjjm 5983 19 spinal spinal JJ cord-023095-4dannjjm 5983 20 cord cord NN cord-023095-4dannjjm 5983 21 . . . cord-023095-4dannjjm 5984 1 Thymidine thymidine NN cord-023095-4dannjjm 5984 2 kinase kinase NN cord-023095-4dannjjm 5984 3 ( ( -LRB- cord-023095-4dannjjm 5984 4 TK TK NNP cord-023095-4dannjjm 5984 5 ) ) -RRB- cord-023095-4dannjjm 5984 6 is be VBZ cord-023095-4dannjjm 5984 7 a a DT cord-023095-4dannjjm 5984 8 soluble soluble JJ cord-023095-4dannjjm 5984 9 biomarker biomarker NN cord-023095-4dannjjm 5984 10 present present NN cord-023095-4dannjjm 5984 11 in in IN cord-023095-4dannjjm 5984 12 S s NN cord-023095-4dannjjm 5984 13 - - HYPH cord-023095-4dannjjm 5984 14 phase phase NN cord-023095-4dannjjm 5984 15 of of IN cord-023095-4dannjjm 5984 16 a a DT cord-023095-4dannjjm 5984 17 salvage salvage NN cord-023095-4dannjjm 5984 18 pathway pathway NN cord-023095-4dannjjm 5984 19 for for IN cord-023095-4dannjjm 5984 20 DNA dna NN cord-023095-4dannjjm 5984 21 synthesis synthesis NN cord-023095-4dannjjm 5984 22 , , , cord-023095-4dannjjm 5984 23 and and CC cord-023095-4dannjjm 5984 24 can can MD cord-023095-4dannjjm 5984 25 be be VB cord-023095-4dannjjm 5984 26 measured measure VBN cord-023095-4dannjjm 5984 27 in in IN cord-023095-4dannjjm 5984 28 serum serum NN cord-023095-4dannjjm 5984 29 . . . cord-023095-4dannjjm 5985 1 TK TK NNP cord-023095-4dannjjm 5985 2 activity activity NN cord-023095-4dannjjm 5985 3 correlates correlate VBZ cord-023095-4dannjjm 5985 4 with with IN cord-023095-4dannjjm 5985 5 stage stage NN cord-023095-4dannjjm 5985 6 , , , cord-023095-4dannjjm 5985 7 prognosis prognosis NN cord-023095-4dannjjm 5985 8 , , , cord-023095-4dannjjm 5985 9 and and CC cord-023095-4dannjjm 5985 10 relapse relapse NN cord-023095-4dannjjm 5985 11 in in IN cord-023095-4dannjjm 5985 12 canine canine JJ cord-023095-4dannjjm 5985 13 and and CC cord-023095-4dannjjm 5985 14 human human JJ cord-023095-4dannjjm 5985 15 lymphoma lymphoma NN cord-023095-4dannjjm 5985 16 . . . cord-023095-4dannjjm 5986 1 We -PRON- PRP cord-023095-4dannjjm 5986 2 previously previously RB cord-023095-4dannjjm 5986 3 reported report VBD cord-023095-4dannjjm 5986 4 the the DT cord-023095-4dannjjm 5986 5 results result NNS cord-023095-4dannjjm 5986 6 of of IN cord-023095-4dannjjm 5986 7 a a DT cord-023095-4dannjjm 5986 8 pilot pilot NN cord-023095-4dannjjm 5986 9 study study NN cord-023095-4dannjjm 5986 10 evaluating evaluate VBG cord-023095-4dannjjm 5986 11 TK TK NNP cord-023095-4dannjjm 5986 12 activity activity NN cord-023095-4dannjjm 5986 13 in in IN cord-023095-4dannjjm 5986 14 archived archived JJ cord-023095-4dannjjm 5986 15 canine canine JJ cord-023095-4dannjjm 5986 16 osteosarcoma osteosarcoma NN cord-023095-4dannjjm 5986 17 , , , cord-023095-4dannjjm 5986 18 transitional transitional JJ cord-023095-4dannjjm 5986 19 cell cell NN cord-023095-4dannjjm 5986 20 carcinoma carcinoma NN cord-023095-4dannjjm 5986 21 , , , cord-023095-4dannjjm 5986 22 and and CC cord-023095-4dannjjm 5986 23 hemangiosarcoma hemangiosarcoma NN cord-023095-4dannjjm 5986 24 ( ( -LRB- cord-023095-4dannjjm 5986 25 HSA HSA NNP cord-023095-4dannjjm 5986 26 ) ) -RRB- cord-023095-4dannjjm 5986 27 sera sera NNP cord-023095-4dannjjm 5986 28 , , , cord-023095-4dannjjm 5986 29 and and CC cord-023095-4dannjjm 5986 30 found find VBD cord-023095-4dannjjm 5986 31 elevated elevate VBN cord-023095-4dannjjm 5986 32 TK TK NNP cord-023095-4dannjjm 5986 33 activity activity NN cord-023095-4dannjjm 5986 34 in in IN cord-023095-4dannjjm 5986 35 80 80 CD cord-023095-4dannjjm 5986 36 % % NN cord-023095-4dannjjm 5986 37 of of IN cord-023095-4dannjjm 5986 38 canine canine JJ cord-023095-4dannjjm 5986 39 HSA HSA NNP cord-023095-4dannjjm 5986 40 sera sera NNP cord-023095-4dannjjm 5986 41 evaluated evaluate VBD cord-023095-4dannjjm 5986 42 . . . cord-023095-4dannjjm 5987 1 The the DT cord-023095-4dannjjm 5987 2 purpose purpose NN cord-023095-4dannjjm 5987 3 of of IN cord-023095-4dannjjm 5987 4 this this DT cord-023095-4dannjjm 5987 5 study study NN cord-023095-4dannjjm 5987 6 was be VBD cord-023095-4dannjjm 5987 7 to to TO cord-023095-4dannjjm 5987 8 prospectively prospectively RB cord-023095-4dannjjm 5987 9 evaluate evaluate VB cord-023095-4dannjjm 5987 10 serum serum NN cord-023095-4dannjjm 5987 11 TK tk NN cord-023095-4dannjjm 5987 12 activity activity NN cord-023095-4dannjjm 5987 13 in in IN cord-023095-4dannjjm 5987 14 a a DT cord-023095-4dannjjm 5987 15 large large JJ cord-023095-4dannjjm 5987 16 number number NN cord-023095-4dannjjm 5987 17 of of IN cord-023095-4dannjjm 5987 18 dogs dog NNS cord-023095-4dannjjm 5987 19 presenting present VBG cord-023095-4dannjjm 5987 20 to to IN cord-023095-4dannjjm 5987 21 emergency emergency NN cord-023095-4dannjjm 5987 22 clinics clinic NNS cord-023095-4dannjjm 5987 23 with with IN cord-023095-4dannjjm 5987 24 hemoabdomen hemoabdomen NNP cord-023095-4dannjjm 5987 25 and and CC cord-023095-4dannjjm 5987 26 a a DT cord-023095-4dannjjm 5987 27 splenic splenic JJ cord-023095-4dannjjm 5987 28 mass mass NN cord-023095-4dannjjm 5987 29 , , , cord-023095-4dannjjm 5987 30 to to TO cord-023095-4dannjjm 5987 31 determine determine VB cord-023095-4dannjjm 5987 32 if if IN cord-023095-4dannjjm 5987 33 TK TK NNP cord-023095-4dannjjm 5987 34 activity activity NN cord-023095-4dannjjm 5987 35 could could MD cord-023095-4dannjjm 5987 36 be be VB cord-023095-4dannjjm 5987 37 used use VBN cord-023095-4dannjjm 5987 38 as as IN cord-023095-4dannjjm 5987 39 a a DT cord-023095-4dannjjm 5987 40 noninvasive noninvasive JJ cord-023095-4dannjjm 5987 41 means mean NNS cord-023095-4dannjjm 5987 42 to to TO cord-023095-4dannjjm 5987 43 distinguish distinguish VB cord-023095-4dannjjm 5987 44 HSA HSA NNP cord-023095-4dannjjm 5987 45 versus versus IN cord-023095-4dannjjm 5987 46 benign benign JJ cord-023095-4dannjjm 5987 47 conditions condition NNS cord-023095-4dannjjm 5987 48 in in IN cord-023095-4dannjjm 5987 49 this this DT cord-023095-4dannjjm 5987 50 population population NN cord-023095-4dannjjm 5987 51 . . . cord-023095-4dannjjm 5988 1 Dogs dog NNS cord-023095-4dannjjm 5988 2 presenting present VBG cord-023095-4dannjjm 5988 3 with with IN cord-023095-4dannjjm 5988 4 hemoabdomen hemoabdomen NNP cord-023095-4dannjjm 5988 5 and and CC cord-023095-4dannjjm 5988 6 a a DT cord-023095-4dannjjm 5988 7 splenic splenic JJ cord-023095-4dannjjm 5988 8 mass mass NN cord-023095-4dannjjm 5988 9 identified identify VBN cord-023095-4dannjjm 5988 10 on on IN cord-023095-4dannjjm 5988 11 ultrasound ultrasound NN cord-023095-4dannjjm 5988 12 examination examination NN cord-023095-4dannjjm 5988 13 were be VBD cord-023095-4dannjjm 5988 14 studied study VBN cord-023095-4dannjjm 5988 15 . . . cord-023095-4dannjjm 5989 1 Serum serum NN cord-023095-4dannjjm 5989 2 was be VBD cord-023095-4dannjjm 5989 3 collected collect VBN cord-023095-4dannjjm 5989 4 prior prior RB cord-023095-4dannjjm 5989 5 to to IN cord-023095-4dannjjm 5989 6 anesthesia anesthesia NN cord-023095-4dannjjm 5989 7 , , , cord-023095-4dannjjm 5989 8 euthanasia euthanasia JJ cord-023095-4dannjjm 5989 9 or or CC cord-023095-4dannjjm 5989 10 surgical surgical JJ cord-023095-4dannjjm 5989 11 intervention intervention NN cord-023095-4dannjjm 5989 12 and and CC cord-023095-4dannjjm 5989 13 frozen freeze VBN cord-023095-4dannjjm 5989 14 until until IN cord-023095-4dannjjm 5989 15 batch batch NN cord-023095-4dannjjm 5989 16 analysis analysis NN cord-023095-4dannjjm 5989 17 . . . cord-023095-4dannjjm 5990 1 Tissue tissue NN cord-023095-4dannjjm 5990 2 from from IN cord-023095-4dannjjm 5990 3 all all DT cord-023095-4dannjjm 5990 4 patients patient NNS cord-023095-4dannjjm 5990 5 was be VBD cord-023095-4dannjjm 5990 6 evaluated evaluate VBN cord-023095-4dannjjm 5990 7 histologically histologically RB cord-023095-4dannjjm 5990 8 by by IN cord-023095-4dannjjm 5990 9 a a DT cord-023095-4dannjjm 5990 10 single single JJ cord-023095-4dannjjm 5990 11 pathologist pathologist NN cord-023095-4dannjjm 5990 12 . . . cord-023095-4dannjjm 5991 1 Sera Sera NNP cord-023095-4dannjjm 5991 2 from from IN cord-023095-4dannjjm 5991 3 age age NN cord-023095-4dannjjm 5991 4 - - HYPH cord-023095-4dannjjm 5991 5 matched match VBN cord-023095-4dannjjm 5991 6 normal normal JJ cord-023095-4dannjjm 5991 7 dogs dog NNS cord-023095-4dannjjm 5991 8 comprised comprise VBD cord-023095-4dannjjm 5991 9 a a DT cord-023095-4dannjjm 5991 10 control control NN cord-023095-4dannjjm 5991 11 population population NN cord-023095-4dannjjm 5991 12 . . . cord-023095-4dannjjm 5992 1 An an DT cord-023095-4dannjjm 5992 2 ELISA ELISA NNP cord-023095-4dannjjm 5992 3 using use VBG cord-023095-4dannjjm 5992 4 azidothymidine azidothymidine NNP cord-023095-4dannjjm 5992 5 as as IN cord-023095-4dannjjm 5992 6 a a DT cord-023095-4dannjjm 5992 7 TK1 tk1 JJ cord-023095-4dannjjm 5992 8 substrate substrate NN cord-023095-4dannjjm 5992 9 was be VBD cord-023095-4dannjjm 5992 10 used use VBN cord-023095-4dannjjm 5992 11 . . . cord-023095-4dannjjm 5993 1 Comparisons comparison NNS cord-023095-4dannjjm 5993 2 between between IN cord-023095-4dannjjm 5993 3 groups group NNS cord-023095-4dannjjm 5993 4 were be VBD cord-023095-4dannjjm 5993 5 made make VBN cord-023095-4dannjjm 5993 6 using use VBG cord-023095-4dannjjm 5993 7 2-tailed 2-tailed CD cord-023095-4dannjjm 5993 8 student student NN cord-023095-4dannjjm 5993 9 T t NN cord-023095-4dannjjm 5993 10 - - HYPH cord-023095-4dannjjm 5993 11 tests test NNS cord-023095-4dannjjm 5993 12 , , , cord-023095-4dannjjm 5993 13 and and CC cord-023095-4dannjjm 5993 14 receiver receiver NN cord-023095-4dannjjm 5993 15 - - HYPH cord-023095-4dannjjm 5993 16 operator operator NN cord-023095-4dannjjm 5993 17 characteristic characteristic NN cord-023095-4dannjjm 5993 18 ( ( -LRB- cord-023095-4dannjjm 5993 19 ROC ROC NNP cord-023095-4dannjjm 5993 20 ) ) -RRB- cord-023095-4dannjjm 5993 21 curves curve NNS cord-023095-4dannjjm 5993 22 were be VBD cord-023095-4dannjjm 5993 23 generated generate VBN cord-023095-4dannjjm 5993 24 . . . cord-023095-4dannjjm 5994 1 Sixty sixty CD cord-023095-4dannjjm 5994 2 - - HYPH cord-023095-4dannjjm 5994 3 two two CD cord-023095-4dannjjm 5994 4 patients patient NNS cord-023095-4dannjjm 5994 5 and and CC cord-023095-4dannjjm 5994 6 39 39 CD cord-023095-4dannjjm 5994 7 normal normal JJ cord-023095-4dannjjm 5994 8 controls control NNS cord-023095-4dannjjm 5994 9 were be VBD cord-023095-4dannjjm 5994 10 studied study VBN cord-023095-4dannjjm 5994 11 . . . cord-023095-4dannjjm 5995 1 There there EX cord-023095-4dannjjm 5995 2 were be VBD cord-023095-4dannjjm 5995 3 35 35 CD cord-023095-4dannjjm 5995 4 dogs dog NNS cord-023095-4dannjjm 5995 5 with with IN cord-023095-4dannjjm 5995 6 HSA HSA NNP cord-023095-4dannjjm 5995 7 , , , cord-023095-4dannjjm 5995 8 10 10 CD cord-023095-4dannjjm 5995 9 dogs dog NNS cord-023095-4dannjjm 5995 10 with with IN cord-023095-4dannjjm 5995 11 other other JJ cord-023095-4dannjjm 5995 12 splenic splenic JJ cord-023095-4dannjjm 5995 13 neoplasia neoplasia NN cord-023095-4dannjjm 5995 14 , , , cord-023095-4dannjjm 5995 15 and and CC cord-023095-4dannjjm 5995 16 17 17 CD cord-023095-4dannjjm 5995 17 dogs dog NNS cord-023095-4dannjjm 5995 18 with with IN cord-023095-4dannjjm 5995 19 benign benign JJ cord-023095-4dannjjm 5995 20 diseases disease NNS cord-023095-4dannjjm 5995 21 . . . cord-023095-4dannjjm 5996 1 Using use VBG cord-023095-4dannjjm 5996 2 a a DT cord-023095-4dannjjm 5996 3 training training NN cord-023095-4dannjjm 5996 4 set set NN cord-023095-4dannjjm 5996 5 of of IN cord-023095-4dannjjm 5996 6 24 24 CD cord-023095-4dannjjm 5996 7 normal normal JJ cord-023095-4dannjjm 5996 8 dogs dog NNS cord-023095-4dannjjm 5996 9 , , , cord-023095-4dannjjm 5996 10 a a DT cord-023095-4dannjjm 5996 11 cutoff cutoff NN cord-023095-4dannjjm 5996 12 of of IN cord-023095-4dannjjm 5996 13 6.55 6.55 CD cord-023095-4dannjjm 5996 14 U U NNP cord-023095-4dannjjm 5996 15 / / SYM cord-023095-4dannjjm 5996 16 L L NNP cord-023095-4dannjjm 5996 17 was be VBD cord-023095-4dannjjm 5996 18 established establish VBN cord-023095-4dannjjm 5996 19 from from IN cord-023095-4dannjjm 5996 20 the the DT cord-023095-4dannjjm 5996 21 ROC ROC NNP cord-023095-4dannjjm 5996 22 curve curve NN cord-023095-4dannjjm 5996 23 . . . cord-023095-4dannjjm 5997 1 TK TK NNP cord-023095-4dannjjm 5997 2 activity activity NN cord-023095-4dannjjm 5997 3 was be VBD cord-023095-4dannjjm 5997 4 significantly significantly RB cord-023095-4dannjjm 5997 5 higher high JJR cord-023095-4dannjjm 5997 6 ( ( -LRB- cord-023095-4dannjjm 5997 7 p p NN cord-023095-4dannjjm 5997 8 o o NN cord-023095-4dannjjm 5997 9 0.0001 0.0001 CD cord-023095-4dannjjm 5997 10 ) ) -RRB- cord-023095-4dannjjm 5997 11 in in IN cord-023095-4dannjjm 5997 12 dogs dog NNS cord-023095-4dannjjm 5997 13 with with IN cord-023095-4dannjjm 5997 14 HSA HSA NNP cord-023095-4dannjjm 5997 15 than than IN cord-023095-4dannjjm 5997 16 in in IN cord-023095-4dannjjm 5997 17 the the DT cord-023095-4dannjjm 5997 18 validation validation NN cord-023095-4dannjjm 5997 19 set set VBN cord-023095-4dannjjm 5997 20 of of IN cord-023095-4dannjjm 5997 21 15 15 CD cord-023095-4dannjjm 5997 22 normal normal JJ cord-023095-4dannjjm 5997 23 dogs dog NNS cord-023095-4dannjjm 5997 24 ( ( -LRB- cord-023095-4dannjjm 5997 25 mean1 mean1 NN cord-023095-4dannjjm 5997 26 / / SYM cord-023095-4dannjjm 5997 27 ÀSD ÀSD NNP cord-023095-4dannjjm 5997 28 5 5 CD cord-023095-4dannjjm 5998 1 17.711 17.711 LS cord-023095-4dannjjm 5998 2 / / SYM cord-023095-4dannjjm 5998 3 À4.5 à4.5 CD cord-023095-4dannjjm 5998 4 and and CC cord-023095-4dannjjm 5998 5 2.011 2.011 CD cord-023095-4dannjjm 5998 6 / / SYM cord-023095-4dannjjm 5998 7 À0.6 à0.6 CD cord-023095-4dannjjm 5998 8 respectively respectively RB cord-023095-4dannjjm 5998 9 ) ) -RRB- cord-023095-4dannjjm 5998 10 , , , cord-023095-4dannjjm 5998 11 but but CC cord-023095-4dannjjm 5998 12 not not RB cord-023095-4dannjjm 5998 13 between between IN cord-023095-4dannjjm 5998 14 dogs dog NNS cord-023095-4dannjjm 5998 15 with with IN cord-023095-4dannjjm 5998 16 HSA HSA NNP cord-023095-4dannjjm 5998 17 and and CC cord-023095-4dannjjm 5998 18 benign benign JJ cord-023095-4dannjjm 5998 19 splenic splenic JJ cord-023095-4dannjjm 5998 20 disease disease NN cord-023095-4dannjjm 5999 1 ( ( -LRB- cord-023095-4dannjjm 5999 2 mean1 mean1 NN cord-023095-4dannjjm 5999 3 / / SYM cord-023095-4dannjjm 5999 4 ÀSD ÀSD NNP cord-023095-4dannjjm 5999 5 5 5 CD cord-023095-4dannjjm 5999 6 7.021/ 7.021/ CD cord-023095-4dannjjm 6000 1 À3.7 À3.7 NNP cord-023095-4dannjjm 6000 2 , , , cord-023095-4dannjjm 6000 3 p p NN cord-023095-4dannjjm 6000 4 5 5 CD cord-023095-4dannjjm 6000 5 0.13 0.13 CD cord-023095-4dannjjm 6000 6 ) ) -RRB- cord-023095-4dannjjm 6000 7 . . . cord-023095-4dannjjm 6001 1 Using use VBG cord-023095-4dannjjm 6001 2 a a DT cord-023095-4dannjjm 6001 3 cutoff cutoff NN cord-023095-4dannjjm 6001 4 of of IN cord-023095-4dannjjm 6001 5 6.55 6.55 CD cord-023095-4dannjjm 6001 6 U U NNP cord-023095-4dannjjm 6001 7 / / SYM cord-023095-4dannjjm 6001 8 L L NNP cord-023095-4dannjjm 6001 9 , , , cord-023095-4dannjjm 6001 10 TK TK NNP cord-023095-4dannjjm 6001 11 activity activity NN cord-023095-4dannjjm 6001 12 demonstrated demonstrate VBD cord-023095-4dannjjm 6001 13 a a DT cord-023095-4dannjjm 6001 14 sensitivity sensitivity NN cord-023095-4dannjjm 6001 15 of of IN cord-023095-4dannjjm 6001 16 0.54 0.54 CD cord-023095-4dannjjm 6001 17 , , , cord-023095-4dannjjm 6001 18 specificity specificity NN cord-023095-4dannjjm 6001 19 of of IN cord-023095-4dannjjm 6001 20 0.76 0.76 CD cord-023095-4dannjjm 6001 21 , , , cord-023095-4dannjjm 6001 22 positive positive JJ cord-023095-4dannjjm 6001 23 predictive predictive JJ cord-023095-4dannjjm 6001 24 value value NN cord-023095-4dannjjm 6001 25 of of IN cord-023095-4dannjjm 6001 26 0.83 0.83 CD cord-023095-4dannjjm 6001 27 and and CC cord-023095-4dannjjm 6001 28 negative negative JJ cord-023095-4dannjjm 6001 29 predictive predictive JJ cord-023095-4dannjjm 6001 30 value value NN cord-023095-4dannjjm 6001 31 of of IN cord-023095-4dannjjm 6001 32 0.45 0.45 CD cord-023095-4dannjjm 6001 33 for for IN cord-023095-4dannjjm 6001 34 distinguishing distinguish VBG cord-023095-4dannjjm 6001 35 HSA HSA NNP cord-023095-4dannjjm 6001 36 versus versus IN cord-023095-4dannjjm 6001 37 benign benign JJ cord-023095-4dannjjm 6001 38 splenic splenic JJ cord-023095-4dannjjm 6001 39 disease disease NN cord-023095-4dannjjm 6001 40 . . . cord-023095-4dannjjm 6002 1 When when WRB cord-023095-4dannjjm 6002 2 interval interval NN cord-023095-4dannjjm 6002 3 thresholds threshold NNS cord-023095-4dannjjm 6002 4 of of IN cord-023095-4dannjjm 6002 5 o o CD cord-023095-4dannjjm 6002 6 1.55 1.55 CD cord-023095-4dannjjm 6002 7 and and CC cord-023095-4dannjjm 6002 8 47.95 47.95 CD cord-023095-4dannjjm 6002 9 U U NNP cord-023095-4dannjjm 6002 10 / / SYM cord-023095-4dannjjm 6002 11 L L NNP cord-023095-4dannjjm 6002 12 were be VBD cord-023095-4dannjjm 6002 13 used use VBN cord-023095-4dannjjm 6002 14 together together RB cord-023095-4dannjjm 6002 15 , , , cord-023095-4dannjjm 6002 16 diagnostic diagnostic JJ cord-023095-4dannjjm 6002 17 utility utility NN cord-023095-4dannjjm 6002 18 was be VBD cord-023095-4dannjjm 6002 19 markedly markedly RB cord-023095-4dannjjm 6002 20 increased increase VBN cord-023095-4dannjjm 6002 21 for for IN cord-023095-4dannjjm 6002 22 distinguishing distinguish VBG cord-023095-4dannjjm 6002 23 both both CC cord-023095-4dannjjm 6002 24 HSA HSA NNP cord-023095-4dannjjm 6002 25 versus versus IN cord-023095-4dannjjm 6002 26 normal normal JJ cord-023095-4dannjjm 6002 27 and and CC cord-023095-4dannjjm 6002 28 HSA HSA NNP cord-023095-4dannjjm 6002 29 versus versus IN cord-023095-4dannjjm 6002 30 benign benign JJ cord-023095-4dannjjm 6002 31 disease disease NN cord-023095-4dannjjm 6002 32 . . . cord-023095-4dannjjm 6003 1 In in IN cord-023095-4dannjjm 6003 2 conclusion conclusion NN cord-023095-4dannjjm 6003 3 , , , cord-023095-4dannjjm 6003 4 serum serum NN cord-023095-4dannjjm 6003 5 TK TK NNP cord-023095-4dannjjm 6003 6 evaluation evaluation NN cord-023095-4dannjjm 6003 7 may may MD cord-023095-4dannjjm 6003 8 assist assist VB cord-023095-4dannjjm 6003 9 in in IN cord-023095-4dannjjm 6003 10 detection detection NN cord-023095-4dannjjm 6003 11 of of IN cord-023095-4dannjjm 6003 12 canine canine JJ cord-023095-4dannjjm 6003 13 HSA HSA NNP cord-023095-4dannjjm 6003 14 , , , cord-023095-4dannjjm 6003 15 and and CC cord-023095-4dannjjm 6003 16 may may MD cord-023095-4dannjjm 6003 17 also also RB cord-023095-4dannjjm 6003 18 discriminate discriminate VB cord-023095-4dannjjm 6003 19 between between IN cord-023095-4dannjjm 6003 20 benign benign JJ cord-023095-4dannjjm 6003 21 disease disease NN cord-023095-4dannjjm 6003 22 and and CC cord-023095-4dannjjm 6003 23 HSA HSA NNP cord-023095-4dannjjm 6003 24 in in IN cord-023095-4dannjjm 6003 25 dogs dog NNS cord-023095-4dannjjm 6003 26 with with IN cord-023095-4dannjjm 6003 27 hemoabdomen hemoabdomen NNP cord-023095-4dannjjm 6003 28 and and CC cord-023095-4dannjjm 6003 29 a a DT cord-023095-4dannjjm 6003 30 splenic splenic JJ cord-023095-4dannjjm 6003 31 mass mass NN cord-023095-4dannjjm 6003 32 . . . cord-023095-4dannjjm 6004 1 T T NNP cord-023095-4dannjjm 6004 2 cell cell NN cord-023095-4dannjjm 6004 3 chronic chronic NN cord-023095-4dannjjm 6004 4 lymphocytic lymphocytic JJ cord-023095-4dannjjm 6004 5 leukemia leukemia NN cord-023095-4dannjjm 6004 6 ( ( -LRB- cord-023095-4dannjjm 6004 7 CLL CLL NNP cord-023095-4dannjjm 6004 8 ) ) -RRB- cord-023095-4dannjjm 6004 9 is be VBZ cord-023095-4dannjjm 6004 10 a a DT cord-023095-4dannjjm 6004 11 heterogeneous heterogeneous JJ cord-023095-4dannjjm 6004 12 disease disease NN cord-023095-4dannjjm 6004 13 that that WDT cord-023095-4dannjjm 6004 14 affects affect VBZ cord-023095-4dannjjm 6004 15 a a DT cord-023095-4dannjjm 6004 16 number number NN cord-023095-4dannjjm 6004 17 of of IN cord-023095-4dannjjm 6004 18 dog dog NN cord-023095-4dannjjm 6004 19 breeds breed NNS cord-023095-4dannjjm 6004 20 . . . cord-023095-4dannjjm 6005 1 CLL CLL NNP cord-023095-4dannjjm 6005 2 patients patient NNS cord-023095-4dannjjm 6005 3 have have VBP cord-023095-4dannjjm 6005 4 variable variable JJ cord-023095-4dannjjm 6005 5 disease disease NN cord-023095-4dannjjm 6005 6 outcomes outcome NNS cord-023095-4dannjjm 6005 7 . . . cord-023095-4dannjjm 6006 1 The the DT cord-023095-4dannjjm 6006 2 objectives objective NNS cord-023095-4dannjjm 6006 3 of of IN cord-023095-4dannjjm 6006 4 this this DT cord-023095-4dannjjm 6006 5 study study NN cord-023095-4dannjjm 6006 6 were be VBD cord-023095-4dannjjm 6006 7 to to TO cord-023095-4dannjjm 6006 8 use use VB cord-023095-4dannjjm 6006 9 gene gene NN cord-023095-4dannjjm 6006 10 expression expression NN cord-023095-4dannjjm 6006 11 profiling profiling NN cord-023095-4dannjjm 6006 12 of of IN cord-023095-4dannjjm 6006 13 CD8 CD8 NNP cord-023095-4dannjjm 6006 14 T T NNP cord-023095-4dannjjm 6006 15 cell cell NN cord-023095-4dannjjm 6006 16 leukemias leukemia NNS cord-023095-4dannjjm 6006 17 with with IN cord-023095-4dannjjm 6006 18 variable variable JJ cord-023095-4dannjjm 6006 19 outcomes outcome NNS cord-023095-4dannjjm 6006 20 in in IN cord-023095-4dannjjm 6006 21 order order NN cord-023095-4dannjjm 6006 22 to to TO cord-023095-4dannjjm 6006 23 identify identify VB cord-023095-4dannjjm 6006 24 markers marker NNS cord-023095-4dannjjm 6006 25 that that WDT cord-023095-4dannjjm 6006 26 can can MD cord-023095-4dannjjm 6006 27 be be VB cord-023095-4dannjjm 6006 28 used use VBN cord-023095-4dannjjm 6006 29 in in IN cord-023095-4dannjjm 6006 30 routine routine JJ cord-023095-4dannjjm 6006 31 diagnostic diagnostic JJ cord-023095-4dannjjm 6006 32 tests test NNS cord-023095-4dannjjm 6006 33 to to TO cord-023095-4dannjjm 6006 34 distinguish distinguish VB cord-023095-4dannjjm 6006 35 good good JJ cord-023095-4dannjjm 6006 36 from from IN cord-023095-4dannjjm 6006 37 poor poor JJ cord-023095-4dannjjm 6006 38 prognosis prognosis NN cord-023095-4dannjjm 6006 39 disease disease NN cord-023095-4dannjjm 6006 40 , , , cord-023095-4dannjjm 6006 41 and and CC cord-023095-4dannjjm 6006 42 to to TO cord-023095-4dannjjm 6006 43 identify identify VB cord-023095-4dannjjm 6006 44 potential potential JJ cord-023095-4dannjjm 6006 45 targets target NNS cord-023095-4dannjjm 6006 46 for for IN cord-023095-4dannjjm 6006 47 novel novel NN cord-023095-4dannjjm 6006 48 therapy therapy NN cord-023095-4dannjjm 6006 49 . . . cord-023095-4dannjjm 6007 1 Gene gene NN cord-023095-4dannjjm 6007 2 expression expression NN cord-023095-4dannjjm 6007 3 profiling profiling NN cord-023095-4dannjjm 6007 4 of of IN cord-023095-4dannjjm 6007 5 12 12 CD cord-023095-4dannjjm 6007 6 CD8 CD8 NNP cord-023095-4dannjjm 6007 7 T T NNP cord-023095-4dannjjm 6007 8 cell cell NN cord-023095-4dannjjm 6007 9 leukemias leukemia NNS cord-023095-4dannjjm 6007 10 ( ( -LRB- cord-023095-4dannjjm 6007 11 7 7 CD cord-023095-4dannjjm 6007 12 good good JJ cord-023095-4dannjjm 6007 13 , , , cord-023095-4dannjjm 6007 14 5 5 CD cord-023095-4dannjjm 6007 15 poor poor JJ cord-023095-4dannjjm 6007 16 prognosis prognosis NN cord-023095-4dannjjm 6007 17 ) ) -RRB- cord-023095-4dannjjm 6007 18 was be VBD cord-023095-4dannjjm 6007 19 conducted conduct VBN cord-023095-4dannjjm 6007 20 . . . cord-023095-4dannjjm 6008 1 Samples sample NNS cord-023095-4dannjjm 6008 2 from from IN cord-023095-4dannjjm 6008 3 6 6 CD cord-023095-4dannjjm 6008 4 normal normal JJ cord-023095-4dannjjm 6008 5 dogs dog NNS cord-023095-4dannjjm 6008 6 were be VBD cord-023095-4dannjjm 6008 7 also also RB cord-023095-4dannjjm 6008 8 profiled profile VBN cord-023095-4dannjjm 6008 9 . . . cord-023095-4dannjjm 6009 1 Several several JJ cord-023095-4dannjjm 6009 2 differentially differentially RB cord-023095-4dannjjm 6009 3 expressed express VBN cord-023095-4dannjjm 6009 4 genes gene NNS cord-023095-4dannjjm 6009 5 were be VBD cord-023095-4dannjjm 6009 6 found find VBN cord-023095-4dannjjm 6009 7 including include VBG cord-023095-4dannjjm 6009 8 CD9 CD9 NNP cord-023095-4dannjjm 6009 9 , , , cord-023095-4dannjjm 6009 10 CD94 CD94 NNP cord-023095-4dannjjm 6009 11 , , , cord-023095-4dannjjm 6009 12 and and CC cord-023095-4dannjjm 6009 13 CD CD NNP cord-023095-4dannjjm 6009 14 25 25 CD cord-023095-4dannjjm 6009 15 . . . cord-023095-4dannjjm 6010 1 These these DT cord-023095-4dannjjm 6010 2 were be VBD cord-023095-4dannjjm 6010 3 selected select VBN cord-023095-4dannjjm 6010 4 for for IN cord-023095-4dannjjm 6010 5 further further JJ cord-023095-4dannjjm 6010 6 study study NN cord-023095-4dannjjm 6010 7 using use VBG cord-023095-4dannjjm 6010 8 flow flow NN cord-023095-4dannjjm 6010 9 cytometry cytometry NN cord-023095-4dannjjm 6010 10 to to TO cord-023095-4dannjjm 6010 11 determine determine VB cord-023095-4dannjjm 6010 12 expression expression NN cord-023095-4dannjjm 6010 13 of of IN cord-023095-4dannjjm 6010 14 protein protein NN cord-023095-4dannjjm 6010 15 on on IN cord-023095-4dannjjm 6010 16 the the DT cord-023095-4dannjjm 6010 17 cell cell NN cord-023095-4dannjjm 6010 18 surface surface NN cord-023095-4dannjjm 6010 19 . . . cord-023095-4dannjjm 6011 1 Seventy seventy CD cord-023095-4dannjjm 6011 2 nine nine CD cord-023095-4dannjjm 6011 3 cases case NNS cord-023095-4dannjjm 6011 4 of of IN cord-023095-4dannjjm 6011 5 CD81 CD81 NNP cord-023095-4dannjjm 6011 6 T T NNP cord-023095-4dannjjm 6011 7 cell cell NN cord-023095-4dannjjm 6011 8 leukemia leukemia NN cord-023095-4dannjjm 6011 9 were be VBD cord-023095-4dannjjm 6011 10 screened screen VBN cord-023095-4dannjjm 6011 11 for for IN cord-023095-4dannjjm 6011 12 CD CD NNP cord-023095-4dannjjm 6011 13 9 9 CD cord-023095-4dannjjm 6011 14 expression expression NN cord-023095-4dannjjm 6011 15 . . . cord-023095-4dannjjm 6012 1 Forty forty CD cord-023095-4dannjjm 6012 2 seven seven CD cord-023095-4dannjjm 6012 3 had have VBD cord-023095-4dannjjm 6012 4 associated associate VBN cord-023095-4dannjjm 6012 5 outcome outcome NN cord-023095-4dannjjm 6012 6 information information NN cord-023095-4dannjjm 6012 7 . . . cord-023095-4dannjjm 6013 1 Based base VBN cord-023095-4dannjjm 6013 2 on on IN cord-023095-4dannjjm 6013 3 analysis analysis NN cord-023095-4dannjjm 6013 4 to to IN cord-023095-4dannjjm 6013 5 date date NN cord-023095-4dannjjm 6013 6 , , , cord-023095-4dannjjm 6013 7 CD9 CD9 NNP cord-023095-4dannjjm 6013 8 expression expression NN cord-023095-4dannjjm 6013 9 as as IN cord-023095-4dannjjm 6013 10 assessed assess VBN cord-023095-4dannjjm 6013 11 by by IN cord-023095-4dannjjm 6013 12 flow flow NN cord-023095-4dannjjm 6013 13 cytometry cytometry NN cord-023095-4dannjjm 6013 14 does do VBZ cord-023095-4dannjjm 6013 15 not not RB cord-023095-4dannjjm 6013 16 appear appear VB cord-023095-4dannjjm 6013 17 to to TO cord-023095-4dannjjm 6013 18 provide provide VB cord-023095-4dannjjm 6013 19 prognostic prognostic JJ cord-023095-4dannjjm 6013 20 information information NN cord-023095-4dannjjm 6013 21 . . . cord-023095-4dannjjm 6014 1 A a DT cord-023095-4dannjjm 6014 2 monoclonal monoclonal JJ cord-023095-4dannjjm 6014 3 antibody antibody NN cord-023095-4dannjjm 6014 4 to to IN cord-023095-4dannjjm 6014 5 CD25 CD25 NNP cord-023095-4dannjjm 6014 6 was be VBD cord-023095-4dannjjm 6014 7 recently recently RB cord-023095-4dannjjm 6014 8 made make VBN cord-023095-4dannjjm 6014 9 available available JJ cord-023095-4dannjjm 6014 10 . . . cord-023095-4dannjjm 6015 1 To to IN cord-023095-4dannjjm 6015 2 date date NN cord-023095-4dannjjm 6015 3 33 33 CD cord-023095-4dannjjm 6015 4 patients patient NNS cord-023095-4dannjjm 6015 5 with with IN cord-023095-4dannjjm 6015 6 CD8 CD8 NNP cord-023095-4dannjjm 6015 7 T T NNP cord-023095-4dannjjm 6015 8 cell cell NN cord-023095-4dannjjm 6015 9 leukemia leukemia NN cord-023095-4dannjjm 6015 10 have have VBP cord-023095-4dannjjm 6015 11 been be VBN cord-023095-4dannjjm 6015 12 profiled profile VBN cord-023095-4dannjjm 6015 13 . . . cord-023095-4dannjjm 6016 1 CD25 CD25 NNP cord-023095-4dannjjm 6016 2 is be VBZ cord-023095-4dannjjm 6016 3 variably variably RB cord-023095-4dannjjm 6016 4 expressed express VBN cord-023095-4dannjjm 6016 5 on on IN cord-023095-4dannjjm 6016 6 T T NNP cord-023095-4dannjjm 6016 7 cell cell NN cord-023095-4dannjjm 6016 8 leukemias leukemia NNS cord-023095-4dannjjm 6016 9 compared compare VBN cord-023095-4dannjjm 6016 10 to to IN cord-023095-4dannjjm 6016 11 normal normal JJ cord-023095-4dannjjm 6016 12 CD8 CD8 NNP cord-023095-4dannjjm 6016 13 T T NNP cord-023095-4dannjjm 6016 14 cells cell NNS cord-023095-4dannjjm 6016 15 . . . cord-023095-4dannjjm 6017 1 CD25 CD25 NNP cord-023095-4dannjjm 6017 2 is be VBZ cord-023095-4dannjjm 6017 3 the the DT cord-023095-4dannjjm 6017 4 receptor receptor NN cord-023095-4dannjjm 6017 5 for for IN cord-023095-4dannjjm 6017 6 interleukin interleukin NN cord-023095-4dannjjm 6017 7 2 2 CD cord-023095-4dannjjm 6017 8 . . . cord-023095-4dannjjm 6018 1 Cyclosporin Cyclosporin NNP cord-023095-4dannjjm 6018 2 , , , cord-023095-4dannjjm 6018 3 a a DT cord-023095-4dannjjm 6018 4 commonly commonly RB cord-023095-4dannjjm 6018 5 used use VBN cord-023095-4dannjjm 6018 6 immunosuppressive immunosuppressive JJ cord-023095-4dannjjm 6018 7 drug drug NN cord-023095-4dannjjm 6018 8 , , , cord-023095-4dannjjm 6018 9 inhibits inhibit VBZ cord-023095-4dannjjm 6018 10 IL-2 il-2 NN cord-023095-4dannjjm 6018 11 production production NN cord-023095-4dannjjm 6018 12 , , , cord-023095-4dannjjm 6018 13 and and CC cord-023095-4dannjjm 6018 14 has have VBZ cord-023095-4dannjjm 6018 15 been be VBN cord-023095-4dannjjm 6018 16 used use VBN cord-023095-4dannjjm 6018 17 to to TO cord-023095-4dannjjm 6018 18 treat treat VB cord-023095-4dannjjm 6018 19 a a DT cord-023095-4dannjjm 6018 20 subset subset NN cord-023095-4dannjjm 6018 21 of of IN cord-023095-4dannjjm 6018 22 T T NNP cord-023095-4dannjjm 6018 23 cell cell NN cord-023095-4dannjjm 6018 24 leukemias leukemia NNS cord-023095-4dannjjm 6018 25 in in IN cord-023095-4dannjjm 6018 26 people people NNS cord-023095-4dannjjm 6018 27 . . . cord-023095-4dannjjm 6019 1 Thus thus RB cord-023095-4dannjjm 6019 2 , , , cord-023095-4dannjjm 6019 3 the the DT cord-023095-4dannjjm 6019 4 finding finding NN cord-023095-4dannjjm 6019 5 that that IN cord-023095-4dannjjm 6019 6 CD25 CD25 NNP cord-023095-4dannjjm 6019 7 is be VBZ cord-023095-4dannjjm 6019 8 up up RB cord-023095-4dannjjm 6019 9 regulated regulate VBN cord-023095-4dannjjm 6019 10 on on IN cord-023095-4dannjjm 6019 11 T T NNP cord-023095-4dannjjm 6019 12 cell cell NN cord-023095-4dannjjm 6019 13 leukemias leukemia NNS cord-023095-4dannjjm 6019 14 compared compare VBN cord-023095-4dannjjm 6019 15 with with IN cord-023095-4dannjjm 6019 16 normal normal JJ cord-023095-4dannjjm 6019 17 T t NN cord-023095-4dannjjm 6019 18 cells cell NNS cord-023095-4dannjjm 6019 19 suggests suggest VBZ cord-023095-4dannjjm 6019 20 a a DT cord-023095-4dannjjm 6019 21 possible possible JJ cord-023095-4dannjjm 6019 22 new new JJ cord-023095-4dannjjm 6019 23 therapeutic therapeutic JJ cord-023095-4dannjjm 6019 24 avenue avenue NN cord-023095-4dannjjm 6019 25 . . . cord-023095-4dannjjm 6020 1 Recent recent JJ cord-023095-4dannjjm 6020 2 molecular molecular JJ cord-023095-4dannjjm 6020 3 studies study NNS cord-023095-4dannjjm 6020 4 have have VBP cord-023095-4dannjjm 6020 5 revealed reveal VBN cord-023095-4dannjjm 6020 6 a a DT cord-023095-4dannjjm 6020 7 highly highly RB cord-023095-4dannjjm 6020 8 complex complex JJ cord-023095-4dannjjm 6020 9 bacterial bacterial JJ cord-023095-4dannjjm 6020 10 microbiota microbiota NN cord-023095-4dannjjm 6020 11 in in IN cord-023095-4dannjjm 6020 12 the the DT cord-023095-4dannjjm 6020 13 intestine intestine NN cord-023095-4dannjjm 6020 14 of of IN cord-023095-4dannjjm 6020 15 dogs dog NNS cord-023095-4dannjjm 6020 16 . . . cord-023095-4dannjjm 6021 1 There there EX cord-023095-4dannjjm 6021 2 is be VBZ cord-023095-4dannjjm 6021 3 mounting mount VBG cord-023095-4dannjjm 6021 4 evidence evidence NN cord-023095-4dannjjm 6021 5 that that IN cord-023095-4dannjjm 6021 6 microbes microbe NNS cord-023095-4dannjjm 6021 7 play play VBP cord-023095-4dannjjm 6021 8 an an DT cord-023095-4dannjjm 6021 9 important important JJ cord-023095-4dannjjm 6021 10 role role NN cord-023095-4dannjjm 6021 11 in in IN cord-023095-4dannjjm 6021 12 the the DT cord-023095-4dannjjm 6021 13 pathogenesis pathogenesis NN cord-023095-4dannjjm 6021 14 of of IN cord-023095-4dannjjm 6021 15 acute acute JJ cord-023095-4dannjjm 6021 16 and and CC cord-023095-4dannjjm 6021 17 chronic chronic JJ cord-023095-4dannjjm 6021 18 enteropathies enteropathy NNS cord-023095-4dannjjm 6021 19 of of IN cord-023095-4dannjjm 6021 20 dogs dog NNS cord-023095-4dannjjm 6021 21 , , , cord-023095-4dannjjm 6021 22 including include VBG cord-023095-4dannjjm 6021 23 idiopathic idiopathic JJ cord-023095-4dannjjm 6021 24 inflammatory inflammatory JJ cord-023095-4dannjjm 6021 25 bowel bowel NN cord-023095-4dannjjm 6021 26 disease disease NN cord-023095-4dannjjm 6021 27 ( ( -LRB- cord-023095-4dannjjm 6021 28 IBD IBD NNP cord-023095-4dannjjm 6021 29 ) ) -RRB- cord-023095-4dannjjm 6021 30 . . . cord-023095-4dannjjm 6022 1 Similarly similarly RB cord-023095-4dannjjm 6022 2 , , , cord-023095-4dannjjm 6022 3 compositional compositional JJ cord-023095-4dannjjm 6022 4 changes change NNS cord-023095-4dannjjm 6022 5 of of IN cord-023095-4dannjjm 6022 6 the the DT cord-023095-4dannjjm 6022 7 intestinal intestinal JJ cord-023095-4dannjjm 6022 8 bacterial bacterial JJ cord-023095-4dannjjm 6022 9 ecosystem ecosystem NN cord-023095-4dannjjm 6022 10 have have VBP cord-023095-4dannjjm 6022 11 been be VBN cord-023095-4dannjjm 6022 12 associated associate VBN cord-023095-4dannjjm 6022 13 with with IN cord-023095-4dannjjm 6022 14 IBD IBD NNP cord-023095-4dannjjm 6022 15 in in IN cord-023095-4dannjjm 6022 16 humans human NNS cord-023095-4dannjjm 6022 17 . . . cord-023095-4dannjjm 6023 1 The the DT cord-023095-4dannjjm 6023 2 aim aim NN cord-023095-4dannjjm 6023 3 of of IN cord-023095-4dannjjm 6023 4 this this DT cord-023095-4dannjjm 6023 5 study study NN cord-023095-4dannjjm 6023 6 was be VBD cord-023095-4dannjjm 6023 7 to to TO cord-023095-4dannjjm 6023 8 characterize characterize VB cord-023095-4dannjjm 6023 9 the the DT cord-023095-4dannjjm 6023 10 bacterial bacterial JJ cord-023095-4dannjjm 6023 11 microbiota microbiota NN cord-023095-4dannjjm 6023 12 in in IN cord-023095-4dannjjm 6023 13 dogs dog NNS cord-023095-4dannjjm 6023 14 with with IN cord-023095-4dannjjm 6023 15 various various JJ cord-023095-4dannjjm 6023 16 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 6023 17 disorders disorder NNS cord-023095-4dannjjm 6023 18 using use VBG cord-023095-4dannjjm 6023 19 a a DT cord-023095-4dannjjm 6023 20 next next JJ cord-023095-4dannjjm 6023 21 generation generation NN cord-023095-4dannjjm 6023 22 sequencing sequencing NN cord-023095-4dannjjm 6023 23 technique technique NN cord-023095-4dannjjm 6023 24 . . . cord-023095-4dannjjm 6024 1 Fecal fecal JJ cord-023095-4dannjjm 6024 2 samples sample NNS cord-023095-4dannjjm 6024 3 were be VBD cord-023095-4dannjjm 6024 4 obtained obtain VBN cord-023095-4dannjjm 6024 5 from from IN cord-023095-4dannjjm 6024 6 healthy healthy JJ cord-023095-4dannjjm 6024 7 dogs dog NNS cord-023095-4dannjjm 6024 8 ( ( -LRB- cord-023095-4dannjjm 6024 9 n n NN cord-023095-4dannjjm 6024 10 5 5 CD cord-023095-4dannjjm 6024 11 31 31 CD cord-023095-4dannjjm 6024 12 ) ) -RRB- cord-023095-4dannjjm 6024 13 , , , cord-023095-4dannjjm 6024 14 dogs dog NNS cord-023095-4dannjjm 6024 15 with with IN cord-023095-4dannjjm 6024 16 acute acute JJ cord-023095-4dannjjm 6024 17 uncomplicated uncomplicated JJ cord-023095-4dannjjm 6024 18 diarrhea diarrhea NN cord-023095-4dannjjm 6024 19 ( ( -LRB- cord-023095-4dannjjm 6024 20 n n NN cord-023095-4dannjjm 6024 21 5 5 CD cord-023095-4dannjjm 6024 22 7 7 CD cord-023095-4dannjjm 6024 23 ) ) -RRB- cord-023095-4dannjjm 6024 24 , , , cord-023095-4dannjjm 6024 25 dogs dog NNS cord-023095-4dannjjm 6024 26 with with IN cord-023095-4dannjjm 6024 27 acute acute JJ cord-023095-4dannjjm 6024 28 hemorrhagic hemorrhagic JJ cord-023095-4dannjjm 6024 29 diarrhea diarrhea NN cord-023095-4dannjjm 6024 30 ( ( -LRB- cord-023095-4dannjjm 6024 31 AHD AHD NNP cord-023095-4dannjjm 6024 32 ; ; : cord-023095-4dannjjm 6024 33 n n NN cord-023095-4dannjjm 6024 34 5 5 CD cord-023095-4dannjjm 6024 35 13 13 CD cord-023095-4dannjjm 6024 36 ) ) -RRB- cord-023095-4dannjjm 6024 37 , , , cord-023095-4dannjjm 6024 38 and and CC cord-023095-4dannjjm 6024 39 dogs dog NNS cord-023095-4dannjjm 6024 40 with with IN cord-023095-4dannjjm 6024 41 active active JJ cord-023095-4dannjjm 6024 42 ( ( -LRB- cord-023095-4dannjjm 6024 43 n n NN cord-023095-4dannjjm 6024 44 5 5 CD cord-023095-4dannjjm 6024 45 8) 8) NN cord-023095-4dannjjm 6024 46 and and CC cord-023095-4dannjjm 6024 47 therapeutically therapeutically RB cord-023095-4dannjjm 6024 48 controlled control VBN cord-023095-4dannjjm 6024 49 IBD IBD NNP cord-023095-4dannjjm 6024 50 ( ( -LRB- cord-023095-4dannjjm 6024 51 n n NN cord-023095-4dannjjm 6024 52 5 5 CD cord-023095-4dannjjm 6024 53 10 10 CD cord-023095-4dannjjm 6024 54 ) ) -RRB- cord-023095-4dannjjm 6024 55 . . . cord-023095-4dannjjm 6025 1 The the DT cord-023095-4dannjjm 6025 2 bacterial bacterial JJ cord-023095-4dannjjm 6025 3 composition composition NN cord-023095-4dannjjm 6025 4 was be VBD cord-023095-4dannjjm 6025 5 analyzed analyze VBN cord-023095-4dannjjm 6025 6 by by IN cord-023095-4dannjjm 6025 7 massive massive JJ cord-023095-4dannjjm 6025 8 parallel parallel NN cord-023095-4dannjjm 6025 9 16S 16S NNP cord-023095-4dannjjm 6025 10 rRNA rrna NN cord-023095-4dannjjm 6025 11 gene gene NN cord-023095-4dannjjm 6025 12 454-pyrosequencing 454-pyrosequencing CD cord-023095-4dannjjm 6025 13 . . . cord-023095-4dannjjm 6026 1 Differences difference NNS cord-023095-4dannjjm 6026 2 between between IN cord-023095-4dannjjm 6026 3 groups group NNS cord-023095-4dannjjm 6026 4 were be VBD cord-023095-4dannjjm 6026 5 analyzed analyze VBN cord-023095-4dannjjm 6026 6 using use VBG cord-023095-4dannjjm 6026 7 Mann Mann NNP cord-023095-4dannjjm 6026 8 - - HYPH cord-023095-4dannjjm 6026 9 Whitney Whitney NNP cord-023095-4dannjjm 6026 10 U U NNP cord-023095-4dannjjm 6026 11 tests test VBZ cord-023095-4dannjjm 6026 12 and and CC cord-023095-4dannjjm 6026 13 Kruskal Kruskal NNP cord-023095-4dannjjm 6026 14 - - HYPH cord-023095-4dannjjm 6026 15 Wallis Wallis NNP cord-023095-4dannjjm 6026 16 tests test NNS cord-023095-4dannjjm 6026 17 followed follow VBN cord-023095-4dannjjm 6026 18 by by IN cord-023095-4dannjjm 6026 19 Dunn Dunn NNP cord-023095-4dannjjm 6026 20 's 's POS cord-023095-4dannjjm 6026 21 multiple multiple JJ cord-023095-4dannjjm 6026 22 comparison comparison NN cord-023095-4dannjjm 6026 23 tests test NNS cord-023095-4dannjjm 6026 24 . . . cord-023095-4dannjjm 6027 1 Statistical statistical JJ cord-023095-4dannjjm 6027 2 significance significance NN cord-023095-4dannjjm 6027 3 was be VBD cord-023095-4dannjjm 6027 4 set set VBN cord-023095-4dannjjm 6027 5 at at IN cord-023095-4dannjjm 6027 6 p p NN cord-023095-4dannjjm 6027 7 o o NN cord-023095-4dannjjm 6027 8 0.05 0.05 CD cord-023095-4dannjjm 6027 9 . . . cord-023095-4dannjjm 6028 1 Significant significant JJ cord-023095-4dannjjm 6028 2 differences difference NNS cord-023095-4dannjjm 6028 3 in in IN cord-023095-4dannjjm 6028 4 the the DT cord-023095-4dannjjm 6028 5 proportions proportion NNS cord-023095-4dannjjm 6028 6 of of IN cord-023095-4dannjjm 6028 7 several several JJ cord-023095-4dannjjm 6028 8 bacterial bacterial JJ cord-023095-4dannjjm 6028 9 groups group NNS cord-023095-4dannjjm 6028 10 were be VBD cord-023095-4dannjjm 6028 11 identified identify VBN cord-023095-4dannjjm 6028 12 between between IN cord-023095-4dannjjm 6028 13 healthy healthy JJ cord-023095-4dannjjm 6028 14 and and CC cord-023095-4dannjjm 6028 15 diseased diseased JJ cord-023095-4dannjjm 6028 16 dogs dog NNS cord-023095-4dannjjm 6028 17 . . . cord-023095-4dannjjm 6029 1 Dogs dog NNS cord-023095-4dannjjm 6029 2 with with IN cord-023095-4dannjjm 6029 3 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 6029 4 disease disease NN cord-023095-4dannjjm 6029 5 had have VBD cord-023095-4dannjjm 6029 6 significantly significantly RB cord-023095-4dannjjm 6029 7 higher high JJR cord-023095-4dannjjm 6029 8 proportions proportion NNS cord-023095-4dannjjm 6029 9 of of IN cord-023095-4dannjjm 6029 10 Proteobacteria Proteobacteria NNP cord-023095-4dannjjm 6029 11 ( ( -LRB- cord-023095-4dannjjm 6029 12 p p NN cord-023095-4dannjjm 6029 13 o o NN cord-023095-4dannjjm 6029 14 0.01 0.01 CD cord-023095-4dannjjm 6029 15 ) ) -RRB- cord-023095-4dannjjm 6029 16 . . . cord-023095-4dannjjm 6030 1 Proportions proportion NNS cord-023095-4dannjjm 6030 2 of of IN cord-023095-4dannjjm 6030 3 Firmicutes Firmicutes NNPS cord-023095-4dannjjm 6030 4 were be VBD cord-023095-4dannjjm 6030 5 lower low JJR cord-023095-4dannjjm 6030 6 in in IN cord-023095-4dannjjm 6030 7 diseased diseased JJ cord-023095-4dannjjm 6030 8 dogs dog NNS cord-023095-4dannjjm 6030 9 , , , cord-023095-4dannjjm 6030 10 but but CC cord-023095-4dannjjm 6030 11 this this DT cord-023095-4dannjjm 6030 12 difference difference NN cord-023095-4dannjjm 6030 13 did do VBD cord-023095-4dannjjm 6030 14 not not RB cord-023095-4dannjjm 6030 15 reach reach VB cord-023095-4dannjjm 6030 16 significance significance NN cord-023095-4dannjjm 6030 17 ( ( -LRB- cord-023095-4dannjjm 6030 18 p p NN cord-023095-4dannjjm 6030 19 5 5 CD cord-023095-4dannjjm 6030 20 0.06 0.06 CD cord-023095-4dannjjm 6030 21 ) ) -RRB- cord-023095-4dannjjm 6030 22 . . . cord-023095-4dannjjm 6031 1 Within within IN cord-023095-4dannjjm 6031 2 the the DT cord-023095-4dannjjm 6031 3 Firmicutes Firmicutes NNPS cord-023095-4dannjjm 6031 4 the the DT cord-023095-4dannjjm 6031 5 most most RBS cord-023095-4dannjjm 6031 6 notable notable JJ cord-023095-4dannjjm 6031 7 findings finding NNS cord-023095-4dannjjm 6031 8 were be VBD cord-023095-4dannjjm 6031 9 decreases decrease NNS cord-023095-4dannjjm 6031 10 in in IN cord-023095-4dannjjm 6031 11 bacterial bacterial JJ cord-023095-4dannjjm 6031 12 groups group NNS cord-023095-4dannjjm 6031 13 belonging belong VBG cord-023095-4dannjjm 6031 14 to to IN cord-023095-4dannjjm 6031 15 Clostridium clostridium NN cord-023095-4dannjjm 6031 16 clusters cluster NNS cord-023095-4dannjjm 6031 17 IV IV NNP cord-023095-4dannjjm 6031 18 and and CC cord-023095-4dannjjm 6031 19 XIVa XIVa NNP cord-023095-4dannjjm 6031 20 ( ( -LRB- cord-023095-4dannjjm 6031 21 i.e. i.e. FW cord-023095-4dannjjm 6031 22 , , , cord-023095-4dannjjm 6031 23 Ruminococcus Ruminococcus NNP cord-023095-4dannjjm 6031 24 , , , cord-023095-4dannjjm 6031 25 Dorea Dorea NNP cord-023095-4dannjjm 6031 26 , , , cord-023095-4dannjjm 6031 27 and and CC cord-023095-4dannjjm 6031 28 Faecalibacterium Faecalibacterium NNP cord-023095-4dannjjm 6031 29 spp spp NNS cord-023095-4dannjjm 6031 30 . . . cord-023095-4dannjjm 6032 1 ; ; : cord-023095-4dannjjm 6032 2 p p NN cord-023095-4dannjjm 6032 3 o o NN cord-023095-4dannjjm 6032 4 0.01 0.01 CD cord-023095-4dannjjm 6032 5 for for IN cord-023095-4dannjjm 6032 6 all all DT cord-023095-4dannjjm 6032 7 ) ) -RRB- cord-023095-4dannjjm 6032 8 . . . cord-023095-4dannjjm 6033 1 Dogs dog NNS cord-023095-4dannjjm 6033 2 with with IN cord-023095-4dannjjm 6033 3 AHD AHD NNP cord-023095-4dannjjm 6033 4 had have VBD cord-023095-4dannjjm 6033 5 the the DT cord-023095-4dannjjm 6033 6 most most RBS cord-023095-4dannjjm 6033 7 profound profound JJ cord-023095-4dannjjm 6033 8 changes change NNS cord-023095-4dannjjm 6033 9 of of IN cord-023095-4dannjjm 6033 10 the the DT cord-023095-4dannjjm 6033 11 microbiota microbiota NN cord-023095-4dannjjm 6033 12 , , , cord-023095-4dannjjm 6033 13 followed follow VBN cord-023095-4dannjjm 6033 14 by by IN cord-023095-4dannjjm 6033 15 dogs dog NNS cord-023095-4dannjjm 6033 16 with with IN cord-023095-4dannjjm 6033 17 acute acute JJ cord-023095-4dannjjm 6033 18 uncomplicated uncomplicated JJ cord-023095-4dannjjm 6033 19 diarrhea diarrhea NN cord-023095-4dannjjm 6033 20 , , , cord-023095-4dannjjm 6033 21 and and CC cord-023095-4dannjjm 6033 22 dogs dog NNS cord-023095-4dannjjm 6033 23 with with IN cord-023095-4dannjjm 6033 24 active active JJ cord-023095-4dannjjm 6033 25 IBD IBD NNP cord-023095-4dannjjm 6033 26 . . . cord-023095-4dannjjm 6034 1 Faecalibacterium Faecalibacterium NNP cord-023095-4dannjjm 6034 2 spp spp NNS cord-023095-4dannjjm 6034 3 . . . cord-023095-4dannjjm 6035 1 was be VBD cord-023095-4dannjjm 6035 2 the the DT cord-023095-4dannjjm 6035 3 bacterial bacterial JJ cord-023095-4dannjjm 6035 4 group group NN cord-023095-4dannjjm 6035 5 most most RBS cord-023095-4dannjjm 6035 6 prominently prominently RB cord-023095-4dannjjm 6035 7 depleted deplete VBN cord-023095-4dannjjm 6035 8 in in IN cord-023095-4dannjjm 6035 9 dogs dog NNS cord-023095-4dannjjm 6035 10 with with IN cord-023095-4dannjjm 6035 11 active active JJ cord-023095-4dannjjm 6035 12 IBD IBD NNP cord-023095-4dannjjm 6035 13 , , , cord-023095-4dannjjm 6035 14 but but CC cord-023095-4dannjjm 6035 15 was be VBD cord-023095-4dannjjm 6035 16 not not RB cord-023095-4dannjjm 6035 17 significantly significantly RB cord-023095-4dannjjm 6035 18 different different JJ cord-023095-4dannjjm 6035 19 between between IN cord-023095-4dannjjm 6035 20 healthy healthy JJ cord-023095-4dannjjm 6035 21 dogs dog NNS cord-023095-4dannjjm 6035 22 and and CC cord-023095-4dannjjm 6035 23 dogs dog NNS cord-023095-4dannjjm 6035 24 with with IN cord-023095-4dannjjm 6035 25 therapeutically therapeutically RB cord-023095-4dannjjm 6035 26 controlled control VBN cord-023095-4dannjjm 6035 27 IBD IBD NNP cord-023095-4dannjjm 6035 28 ( ( -LRB- cord-023095-4dannjjm 6035 29 p p NN cord-023095-4dannjjm 6035 30 5 5 CD cord-023095-4dannjjm 6035 31 0.66 0.66 CD cord-023095-4dannjjm 6035 32 ) ) -RRB- cord-023095-4dannjjm 6035 33 . . . cord-023095-4dannjjm 6036 1 Results result NNS cord-023095-4dannjjm 6036 2 of of IN cord-023095-4dannjjm 6036 3 this this DT cord-023095-4dannjjm 6036 4 study study NN cord-023095-4dannjjm 6036 5 revealed reveal VBD cord-023095-4dannjjm 6036 6 bacterial bacterial JJ cord-023095-4dannjjm 6036 7 dysbiosis dysbiosis NN cord-023095-4dannjjm 6036 8 in in IN cord-023095-4dannjjm 6036 9 fecal fecal JJ cord-023095-4dannjjm 6036 10 samples sample NNS cord-023095-4dannjjm 6036 11 of of IN cord-023095-4dannjjm 6036 12 dogs dog NNS cord-023095-4dannjjm 6036 13 with with IN cord-023095-4dannjjm 6036 14 various various JJ cord-023095-4dannjjm 6036 15 GI GI NNP cord-023095-4dannjjm 6036 16 disorders disorder NNS cord-023095-4dannjjm 6036 17 . . . cord-023095-4dannjjm 6037 1 Bacterial bacterial JJ cord-023095-4dannjjm 6037 2 changes change NNS cord-023095-4dannjjm 6037 3 were be VBD cord-023095-4dannjjm 6037 4 more more RBR cord-023095-4dannjjm 6037 5 profound profound JJ cord-023095-4dannjjm 6037 6 in in IN cord-023095-4dannjjm 6037 7 dogs dog NNS cord-023095-4dannjjm 6037 8 with with IN cord-023095-4dannjjm 6037 9 severe severe JJ cord-023095-4dannjjm 6037 10 disease disease NN cord-023095-4dannjjm 6037 11 , , , cord-023095-4dannjjm 6037 12 but but CC cord-023095-4dannjjm 6037 13 were be VBD cord-023095-4dannjjm 6037 14 not not RB cord-023095-4dannjjm 6037 15 identified identify VBN cord-023095-4dannjjm 6037 16 in in IN cord-023095-4dannjjm 6037 17 dogs dog NNS cord-023095-4dannjjm 6037 18 with with IN cord-023095-4dannjjm 6037 19 therapeutically therapeutically RB cord-023095-4dannjjm 6037 20 controlled control VBN cord-023095-4dannjjm 6037 21 IBD IBD NNP cord-023095-4dannjjm 6037 22 , , , cord-023095-4dannjjm 6037 23 suggesting suggest VBG cord-023095-4dannjjm 6037 24 that that IN cord-023095-4dannjjm 6037 25 the the DT cord-023095-4dannjjm 6037 26 microbiota microbiota NN cord-023095-4dannjjm 6037 27 is be VBZ cord-023095-4dannjjm 6037 28 stable stable JJ cord-023095-4dannjjm 6037 29 in in IN cord-023095-4dannjjm 6037 30 non non JJ cord-023095-4dannjjm 6037 31 - - JJ cord-023095-4dannjjm 6037 32 active active JJ cord-023095-4dannjjm 6037 33 disease disease NN cord-023095-4dannjjm 6037 34 . . . cord-023095-4dannjjm 6038 1 The the DT cord-023095-4dannjjm 6038 2 bacterial bacterial JJ cord-023095-4dannjjm 6038 3 groups group NNS cord-023095-4dannjjm 6038 4 identified identify VBN cord-023095-4dannjjm 6038 5 are be VBP cord-023095-4dannjjm 6038 6 considered consider VBN cord-023095-4dannjjm 6038 7 to to TO cord-023095-4dannjjm 6038 8 be be VB cord-023095-4dannjjm 6038 9 important important JJ cord-023095-4dannjjm 6038 10 short short JJ cord-023095-4dannjjm 6038 11 chain chain NN cord-023095-4dannjjm 6038 12 fatty fatty JJ cord-023095-4dannjjm 6038 13 acid acid NN cord-023095-4dannjjm 6038 14 producers producer NNS cord-023095-4dannjjm 6038 15 and and CC cord-023095-4dannjjm 6038 16 may may MD cord-023095-4dannjjm 6038 17 serve serve VB cord-023095-4dannjjm 6038 18 as as IN cord-023095-4dannjjm 6038 19 candidates candidate NNS cord-023095-4dannjjm 6038 20 for for IN cord-023095-4dannjjm 6038 21 the the DT cord-023095-4dannjjm 6038 22 diagnosis diagnosis NN cord-023095-4dannjjm 6038 23 or or CC cord-023095-4dannjjm 6038 24 therapeutic therapeutic JJ cord-023095-4dannjjm 6038 25 monitoring monitoring NN cord-023095-4dannjjm 6038 26 of of IN cord-023095-4dannjjm 6038 27 GI GI NNP cord-023095-4dannjjm 6038 28 disease disease NN cord-023095-4dannjjm 6038 29 . . . cord-023095-4dannjjm 6039 1 Future future JJ cord-023095-4dannjjm 6039 2 studies study NNS cord-023095-4dannjjm 6039 3 are be VBP cord-023095-4dannjjm 6039 4 necessary necessary JJ cord-023095-4dannjjm 6039 5 to to TO cord-023095-4dannjjm 6039 6 determine determine VB cord-023095-4dannjjm 6039 7 if if IN cord-023095-4dannjjm 6039 8 these these DT cord-023095-4dannjjm 6039 9 microbial microbial JJ cord-023095-4dannjjm 6039 10 changes change NNS cord-023095-4dannjjm 6039 11 correlate correlate VBP cord-023095-4dannjjm 6039 12 with with IN cord-023095-4dannjjm 6039 13 functional functional JJ cord-023095-4dannjjm 6039 14 changes change NNS cord-023095-4dannjjm 6039 15 in in IN cord-023095-4dannjjm 6039 16 the the DT cord-023095-4dannjjm 6039 17 intestinal intestinal JJ cord-023095-4dannjjm 6039 18 microbiota microbiota NN cord-023095-4dannjjm 6039 19 . . . cord-023095-4dannjjm 6040 1 Ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 6040 2 oral oral JJ cord-023095-4dannjjm 6040 3 tablets tablet NNS cord-023095-4dannjjm 6040 4 , , , cord-023095-4dannjjm 6040 5 available available JJ cord-023095-4dannjjm 6040 6 in in IN cord-023095-4dannjjm 6040 7 a a DT cord-023095-4dannjjm 6040 8 generic generic JJ cord-023095-4dannjjm 6040 9 formulation formulation NN cord-023095-4dannjjm 6040 10 for for IN cord-023095-4dannjjm 6040 11 people people NNS cord-023095-4dannjjm 6040 12 , , , cord-023095-4dannjjm 6040 13 are be VBP cord-023095-4dannjjm 6040 14 widely widely RB cord-023095-4dannjjm 6040 15 used use VBN cord-023095-4dannjjm 6040 16 for for IN cord-023095-4dannjjm 6040 17 treatment treatment NN cord-023095-4dannjjm 6040 18 in in IN cord-023095-4dannjjm 6040 19 dogs dog NNS cord-023095-4dannjjm 6040 20 . . . cord-023095-4dannjjm 6041 1 Oral oral JJ cord-023095-4dannjjm 6041 2 absorption absorption NN cord-023095-4dannjjm 6041 3 data datum NNS cord-023095-4dannjjm 6041 4 for for IN cord-023095-4dannjjm 6041 5 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 6041 6 in in IN cord-023095-4dannjjm 6041 7 dogs dog NNS cord-023095-4dannjjm 6041 8 has have VBZ cord-023095-4dannjjm 6041 9 been be VBN cord-023095-4dannjjm 6041 10 variable variable JJ cord-023095-4dannjjm 6041 11 , , , cord-023095-4dannjjm 6041 12 and and CC cord-023095-4dannjjm 6041 13 too too RB cord-023095-4dannjjm 6041 14 limited limited JJ cord-023095-4dannjjm 6041 15 to to TO cord-023095-4dannjjm 6041 16 guide guide VB cord-023095-4dannjjm 6041 17 accurate accurate JJ cord-023095-4dannjjm 6041 18 dosing dosing NN cord-023095-4dannjjm 6041 19 . . . cord-023095-4dannjjm 6042 1 Subsequently subsequently RB cord-023095-4dannjjm 6042 2 , , , cord-023095-4dannjjm 6042 3 published publish VBN cord-023095-4dannjjm 6042 4 doses dose NNS cord-023095-4dannjjm 6042 5 for for IN cord-023095-4dannjjm 6042 6 dogs dog NNS cord-023095-4dannjjm 6042 7 in in IN cord-023095-4dannjjm 6042 8 veterinary veterinary JJ cord-023095-4dannjjm 6042 9 formularies formulary NNS cord-023095-4dannjjm 6042 10 have have VBP cord-023095-4dannjjm 6042 11 varied vary VBN cord-023095-4dannjjm 6042 12 from from IN cord-023095-4dannjjm 6042 13 5 5 CD cord-023095-4dannjjm 6042 14 to to IN cord-023095-4dannjjm 6042 15 25 25 CD cord-023095-4dannjjm 6042 16 mg mg NNP cord-023095-4dannjjm 6042 17 / / SYM cord-023095-4dannjjm 6042 18 kg kg NN cord-023095-4dannjjm 6042 19 . . . cord-023095-4dannjjm 6043 1 This this DT cord-023095-4dannjjm 6043 2 study study NN cord-023095-4dannjjm 6043 3 was be VBD cord-023095-4dannjjm 6043 4 undertaken undertake VBN cord-023095-4dannjjm 6043 5 to to TO cord-023095-4dannjjm 6043 6 explore explore VB cord-023095-4dannjjm 6043 7 the the DT cord-023095-4dannjjm 6043 8 factors factor NNS cord-023095-4dannjjm 6043 9 that that WDT cord-023095-4dannjjm 6043 10 may may MD cord-023095-4dannjjm 6043 11 affect affect VB cord-023095-4dannjjm 6043 12 oral oral JJ cord-023095-4dannjjm 6043 13 absorption absorption NN cord-023095-4dannjjm 6043 14 of of IN cord-023095-4dannjjm 6043 15 generic generic JJ cord-023095-4dannjjm 6043 16 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 6043 17 in in IN cord-023095-4dannjjm 6043 18 dogs dog NNS cord-023095-4dannjjm 6043 19 , , , cord-023095-4dannjjm 6043 20 and and CC cord-023095-4dannjjm 6043 21 to to TO cord-023095-4dannjjm 6043 22 derive derive VB cord-023095-4dannjjm 6043 23 a a DT cord-023095-4dannjjm 6043 24 pharmacokinetic pharmacokinetic NN cord-023095-4dannjjm 6043 25 - - HYPH cord-023095-4dannjjm 6043 26 based base VBN cord-023095-4dannjjm 6043 27 dose dose NN cord-023095-4dannjjm 6043 28 for for IN cord-023095-4dannjjm 6043 29 treating treat VBG cord-023095-4dannjjm 6043 30 susceptible susceptible JJ cord-023095-4dannjjm 6043 31 bacteria bacteria NNS cord-023095-4dannjjm 6043 32 . . . cord-023095-4dannjjm 6044 1 Six six CD cord-023095-4dannjjm 6044 2 healthy healthy JJ cord-023095-4dannjjm 6044 3 adult adult NN cord-023095-4dannjjm 6044 4 beagle beagle NN cord-023095-4dannjjm 6044 5 dogs dog NNS cord-023095-4dannjjm 6044 6 were be VBD cord-023095-4dannjjm 6044 7 used use VBN cord-023095-4dannjjm 6044 8 for for IN cord-023095-4dannjjm 6044 9 the the DT cord-023095-4dannjjm 6044 10 study study NN cord-023095-4dannjjm 6044 11 ( ( -LRB- cord-023095-4dannjjm 6044 12 11.2 11.2 CD cord-023095-4dannjjm 6044 13 kg kg NNS cord-023095-4dannjjm 6044 14 mean mean VBP cord-023095-4dannjjm 6044 15 weight weight NN cord-023095-4dannjjm 6044 16 ) ) -RRB- cord-023095-4dannjjm 6044 17 . . . cord-023095-4dannjjm 6045 1 After after IN cord-023095-4dannjjm 6045 2 placing place VBG cord-023095-4dannjjm 6045 3 jugular jugular NN cord-023095-4dannjjm 6045 4 vein vein NN cord-023095-4dannjjm 6045 5 catheters catheter NNS cord-023095-4dannjjm 6045 6 for for IN cord-023095-4dannjjm 6045 7 collecting collect VBG cord-023095-4dannjjm 6045 8 blood blood NN cord-023095-4dannjjm 6045 9 samples sample NNS cord-023095-4dannjjm 6045 10 , , , cord-023095-4dannjjm 6045 11 these these DT cord-023095-4dannjjm 6045 12 dogs dog NNS cord-023095-4dannjjm 6045 13 were be VBD cord-023095-4dannjjm 6045 14 administered administer VBN cord-023095-4dannjjm 6045 15 either either CC cord-023095-4dannjjm 6045 16 a a DT cord-023095-4dannjjm 6045 17 single single JJ cord-023095-4dannjjm 6045 18 oral oral JJ cord-023095-4dannjjm 6045 19 dose dose NN cord-023095-4dannjjm 6045 20 of of IN cord-023095-4dannjjm 6045 21 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 6045 22 ( ( -LRB- cord-023095-4dannjjm 6045 23 250 250 CD cord-023095-4dannjjm 6045 24 mg mg NN cord-023095-4dannjjm 6045 25 tablet tablet NN cord-023095-4dannjjm 6045 26 ; ; : cord-023095-4dannjjm 6045 27 mean mean VB cord-023095-4dannjjm 6045 28 dose dose NN cord-023095-4dannjjm 6045 29 23 23 CD cord-023095-4dannjjm 6045 30 mg mg NNP cord-023095-4dannjjm 6045 31 / / SYM cord-023095-4dannjjm 6045 32 kg kg NNP cord-023095-4dannjjm 6045 33 ) ) -RRB- cord-023095-4dannjjm 6045 34 , , , cord-023095-4dannjjm 6045 35 or or CC cord-023095-4dannjjm 6045 36 an an DT cord-023095-4dannjjm 6045 37 intravenous intravenous JJ cord-023095-4dannjjm 6045 38 ( ( -LRB- cord-023095-4dannjjm 6045 39 IV IV NNP cord-023095-4dannjjm 6045 40 ) ) -RRB- cord-023095-4dannjjm 6045 41 dose dose NN cord-023095-4dannjjm 6045 42 ( ( -LRB- cord-023095-4dannjjm 6045 43 10 10 CD cord-023095-4dannjjm 6045 44 mg mg NNP cord-023095-4dannjjm 6045 45 / / SYM cord-023095-4dannjjm 6045 46 kg kg NN cord-023095-4dannjjm 6045 47 ; ; : cord-023095-4dannjjm 6045 48 2 2 CD cord-023095-4dannjjm 6045 49 mg mg NNP cord-023095-4dannjjm 6045 50 / / SYM cord-023095-4dannjjm 6045 51 mL ml NN cord-023095-4dannjjm 6045 52 solution solution NN cord-023095-4dannjjm 6045 53 ) ) -RRB- cord-023095-4dannjjm 6045 54 . . . cord-023095-4dannjjm 6046 1 A a DT cord-023095-4dannjjm 6046 2 randomized randomized JJ cord-023095-4dannjjm 6046 3 crossover crossover NN cord-023095-4dannjjm 6046 4 design design NN cord-023095-4dannjjm 6046 5 was be VBD cord-023095-4dannjjm 6046 6 used use VBN cord-023095-4dannjjm 6046 7 with with IN cord-023095-4dannjjm 6046 8 a a DT cord-023095-4dannjjm 6046 9 washout washout NN cord-023095-4dannjjm 6046 10 time time NN cord-023095-4dannjjm 6046 11 between between IN cord-023095-4dannjjm 6046 12 treatments treatment NNS cord-023095-4dannjjm 6046 13 . . . cord-023095-4dannjjm 6047 1 Blood blood NN cord-023095-4dannjjm 6047 2 was be VBD cord-023095-4dannjjm 6047 3 collected collect VBN cord-023095-4dannjjm 6047 4 for for IN cord-023095-4dannjjm 6047 5 plasma plasma NN cord-023095-4dannjjm 6047 6 drug drug NN cord-023095-4dannjjm 6047 7 analysis analysis NN cord-023095-4dannjjm 6047 8 for for IN cord-023095-4dannjjm 6047 9 24 24 CD cord-023095-4dannjjm 6047 10 hours hour NNS cord-023095-4dannjjm 6047 11 . . . cord-023095-4dannjjm 6048 1 Ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 6048 2 concentration concentration NN cord-023095-4dannjjm 6048 3 in in IN cord-023095-4dannjjm 6048 4 plasma plasma NN cord-023095-4dannjjm 6048 5 was be VBD cord-023095-4dannjjm 6048 6 analyzed analyze VBN cord-023095-4dannjjm 6048 7 using use VBG cord-023095-4dannjjm 6048 8 high high JJ cord-023095-4dannjjm 6048 9 pressure pressure NN cord-023095-4dannjjm 6048 10 liquid liquid NN cord-023095-4dannjjm 6048 11 chromatography chromatography NN cord-023095-4dannjjm 6048 12 ( ( -LRB- cord-023095-4dannjjm 6048 13 HPLC HPLC NNP cord-023095-4dannjjm 6048 14 ) ) -RRB- cord-023095-4dannjjm 6048 15 and and CC cord-023095-4dannjjm 6048 16 pharmacokinetics pharmacokinetic NNS cord-023095-4dannjjm 6048 17 analyzed analyze VBD cord-023095-4dannjjm 6048 18 using use VBG cord-023095-4dannjjm 6048 19 a a DT cord-023095-4dannjjm 6048 20 computer computer NN cord-023095-4dannjjm 6048 21 program program NN cord-023095-4dannjjm 6048 22 . . . cord-023095-4dannjjm 6049 1 Oral oral JJ cord-023095-4dannjjm 6049 2 absorption absorption NN cord-023095-4dannjjm 6049 3 was be VBD cord-023095-4dannjjm 6049 4 also also RB cord-023095-4dannjjm 6049 5 evaluated evaluate VBN cord-023095-4dannjjm 6049 6 via via IN cord-023095-4dannjjm 6049 7 deconvolution deconvolution NN cord-023095-4dannjjm 6049 8 analysis analysis NN cord-023095-4dannjjm 6049 9 . . . cord-023095-4dannjjm 6050 1 The the DT cord-023095-4dannjjm 6050 2 oral oral JJ cord-023095-4dannjjm 6050 3 dose dose NN cord-023095-4dannjjm 6050 4 was be VBD cord-023095-4dannjjm 6050 5 well well RB cord-023095-4dannjjm 6050 6 - - HYPH cord-023095-4dannjjm 6050 7 tolerated tolerate VBN cord-023095-4dannjjm 6050 8 , , , cord-023095-4dannjjm 6050 9 but but CC cord-023095-4dannjjm 6050 10 the the DT cord-023095-4dannjjm 6050 11 IV IV NNP cord-023095-4dannjjm 6050 12 dose dose NN cord-023095-4dannjjm 6050 13 produced produce VBN cord-023095-4dannjjm 6050 14 transient transient JJ cord-023095-4dannjjm 6050 15 vomiting vomiting NN cord-023095-4dannjjm 6050 16 and and CC cord-023095-4dannjjm 6050 17 depression depression NN cord-023095-4dannjjm 6050 18 in in IN cord-023095-4dannjjm 6050 19 some some DT cord-023095-4dannjjm 6050 20 dogs dog NNS cord-023095-4dannjjm 6050 21 . . . cord-023095-4dannjjm 6051 1 After after IN cord-023095-4dannjjm 6051 2 the the DT cord-023095-4dannjjm 6051 3 oral oral JJ cord-023095-4dannjjm 6051 4 dose dose NN cord-023095-4dannjjm 6051 5 , , , cord-023095-4dannjjm 6051 6 the the DT cord-023095-4dannjjm 6051 7 peak peak NN cord-023095-4dannjjm 6051 8 plasma plasma NN cord-023095-4dannjjm 6051 9 concentration concentration NN cord-023095-4dannjjm 6051 10 ( ( -LRB- cord-023095-4dannjjm 6051 11 C C NNP cord-023095-4dannjjm 6051 12 MAX MAX NNP cord-023095-4dannjjm 6051 13 ) ) -RRB- cord-023095-4dannjjm 6051 14 was be VBD cord-023095-4dannjjm 6051 15 4.4 4.4 CD cord-023095-4dannjjm 6051 16 mg/ mg/ NN cord-023095-4dannjjm 6051 17 mL ml NN cord-023095-4dannjjm 6052 1 ( ( -LRB- cord-023095-4dannjjm 6052 2 CV CV NNP cord-023095-4dannjjm 6052 3 55.9 55.9 CD cord-023095-4dannjjm 6052 4 % % NN cord-023095-4dannjjm 6052 5 ) ) -RRB- cord-023095-4dannjjm 6052 6 , , , cord-023095-4dannjjm 6052 7 terminal terminal JJ cord-023095-4dannjjm 6052 8 half half JJ cord-023095-4dannjjm 6052 9 - - HYPH cord-023095-4dannjjm 6052 10 life life NN cord-023095-4dannjjm 6052 11 ( ( -LRB- cord-023095-4dannjjm 6052 12 t1/2 t1/2 NNP cord-023095-4dannjjm 6052 13 ) ) -RRB- cord-023095-4dannjjm 6052 14 2.6 2.6 CD cord-023095-4dannjjm 6052 15 hr hr NN cord-023095-4dannjjm 6053 1 ( ( -LRB- cord-023095-4dannjjm 6053 2 CV CV NNP cord-023095-4dannjjm 6053 3 10.8 10.8 CD cord-023095-4dannjjm 6053 4 % % NN cord-023095-4dannjjm 6053 5 ) ) -RRB- cord-023095-4dannjjm 6053 6 , , , cord-023095-4dannjjm 6053 7 AUC AUC NNP cord-023095-4dannjjm 6053 8 22.5 22.5 CD cord-023095-4dannjjm 6053 9 mg mg NNP cord-023095-4dannjjm 6053 10 Á Á NNP cord-023095-4dannjjm 6053 11 hr hr NN cord-023095-4dannjjm 6053 12 / / SYM cord-023095-4dannjjm 6053 13 mL ml NN cord-023095-4dannjjm 6054 1 ( ( -LRB- cord-023095-4dannjjm 6054 2 CV CV NNP cord-023095-4dannjjm 6054 3 62.3 62.3 CD cord-023095-4dannjjm 6054 4 % % NN cord-023095-4dannjjm 6054 5 ) ) -RRB- cord-023095-4dannjjm 6054 6 , , , cord-023095-4dannjjm 6054 7 and and CC cord-023095-4dannjjm 6054 8 systemic systemic JJ cord-023095-4dannjjm 6054 9 absorption absorption NN cord-023095-4dannjjm 6054 10 ( ( -LRB- cord-023095-4dannjjm 6054 11 F F NNP cord-023095-4dannjjm 6054 12 ) ) -RRB- cord-023095-4dannjjm 6054 13 63.7 63.7 CD cord-023095-4dannjjm 6054 14 % % NN cord-023095-4dannjjm 6054 15 ( ( -LRB- cord-023095-4dannjjm 6054 16 CV CV NNP cord-023095-4dannjjm 6054 17 41.6 41.6 CD cord-023095-4dannjjm 6054 18 % % NN cord-023095-4dannjjm 6054 19 ) ) -RRB- cord-023095-4dannjjm 6054 20 . . . cord-023095-4dannjjm 6055 1 After after IN cord-023095-4dannjjm 6055 2 the the DT cord-023095-4dannjjm 6055 3 IV IV NNP cord-023095-4dannjjm 6055 4 dose dose NN cord-023095-4dannjjm 6055 5 , , , cord-023095-4dannjjm 6055 6 the the DT cord-023095-4dannjjm 6055 7 t1/2 t1/2 NNP cord-023095-4dannjjm 6055 8 was be VBD cord-023095-4dannjjm 6055 9 3.7 3.7 CD cord-023095-4dannjjm 6055 10 hr hr NN cord-023095-4dannjjm 6055 11 ( ( -LRB- cord-023095-4dannjjm 6055 12 CV CV NNP cord-023095-4dannjjm 6055 13 52.3 52.3 CD cord-023095-4dannjjm 6055 14 % % NN cord-023095-4dannjjm 6055 15 ) ) -RRB- cord-023095-4dannjjm 6055 16 , , , cord-023095-4dannjjm 6055 17 systemic systemic JJ cord-023095-4dannjjm 6055 18 clearance clearance NN cord-023095-4dannjjm 6055 19 0.587 0.587 CD cord-023095-4dannjjm 6056 1 L L NNP cord-023095-4dannjjm 6056 2 / / SYM cord-023095-4dannjjm 6056 3 kg kg NNP cord-023095-4dannjjm 6056 4 / / SYM cord-023095-4dannjjm 6056 5 hr hr NN cord-023095-4dannjjm 6057 1 ( ( -LRB- cord-023095-4dannjjm 6057 2 CV CV NNP cord-023095-4dannjjm 6057 3 33.9 33.9 CD cord-023095-4dannjjm 6057 4 % % NN cord-023095-4dannjjm 6057 5 ) ) -RRB- cord-023095-4dannjjm 6057 6 , , , cord-023095-4dannjjm 6057 7 and and CC cord-023095-4dannjjm 6057 8 volume volume NN cord-023095-4dannjjm 6057 9 of of IN cord-023095-4dannjjm 6057 10 distribution distribution NN cord-023095-4dannjjm 6057 11 2.39 2.39 CD cord-023095-4dannjjm 6057 12 L l NN cord-023095-4dannjjm 6057 13 / / SYM cord-023095-4dannjjm 6057 14 kg kg NNP cord-023095-4dannjjm 6057 15 ( ( -LRB- cord-023095-4dannjjm 6057 16 CV CV NNP cord-023095-4dannjjm 6057 17 23.7 23.7 CD cord-023095-4dannjjm 6057 18 % % NN cord-023095-4dannjjm 6057 19 ) ) -RRB- cord-023095-4dannjjm 6057 20 . . . cord-023095-4dannjjm 6058 1 After after IN cord-023095-4dannjjm 6058 2 examining examine VBG cord-023095-4dannjjm 6058 3 the the DT cord-023095-4dannjjm 6058 4 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 6058 5 results result NNS cord-023095-4dannjjm 6058 6 from from IN cord-023095-4dannjjm 6058 7 the the DT cord-023095-4dannjjm 6058 8 oral oral JJ cord-023095-4dannjjm 6058 9 dose dose NN cord-023095-4dannjjm 6058 10 , , , cord-023095-4dannjjm 6058 11 it -PRON- PRP cord-023095-4dannjjm 6058 12 was be VBD cord-023095-4dannjjm 6058 13 apparent apparent JJ cord-023095-4dannjjm 6058 14 that that IN cord-023095-4dannjjm 6058 15 oral oral JJ cord-023095-4dannjjm 6058 16 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 6058 17 was be VBD cord-023095-4dannjjm 6058 18 absorbed absorb VBN cord-023095-4dannjjm 6058 19 well well RB cord-023095-4dannjjm 6058 20 in in IN cord-023095-4dannjjm 6058 21 some some DT cord-023095-4dannjjm 6058 22 dogs dog NNS cord-023095-4dannjjm 6058 23 ( ( -LRB- cord-023095-4dannjjm 6058 24 approximately approximately RB cord-023095-4dannjjm 6058 25 80 80 CD cord-023095-4dannjjm 6058 26 % % NN cord-023095-4dannjjm 6058 27 ) ) -RRB- cord-023095-4dannjjm 6058 28 , , , cord-023095-4dannjjm 6058 29 but but CC cord-023095-4dannjjm 6058 30 poorly poorly RB cord-023095-4dannjjm 6058 31 in in IN cord-023095-4dannjjm 6058 32 others other NNS cord-023095-4dannjjm 6058 33 ( ( -LRB- cord-023095-4dannjjm 6058 34 approximately approximately RB cord-023095-4dannjjm 6058 35 30 30 CD cord-023095-4dannjjm 6058 36 % % NN cord-023095-4dannjjm 6058 37 ) ) -RRB- cord-023095-4dannjjm 6058 38 . . . cord-023095-4dannjjm 6059 1 To to TO cord-023095-4dannjjm 6059 2 explore explore VB cord-023095-4dannjjm 6059 3 the the DT cord-023095-4dannjjm 6059 4 factors factor NNS cord-023095-4dannjjm 6059 5 that that WDT cord-023095-4dannjjm 6059 6 may may MD cord-023095-4dannjjm 6059 7 have have VB cord-023095-4dannjjm 6059 8 affected affect VBN cord-023095-4dannjjm 6059 9 oral oral JJ cord-023095-4dannjjm 6059 10 absorption absorption NN cord-023095-4dannjjm 6059 11 , , , cord-023095-4dannjjm 6059 12 two two CD cord-023095-4dannjjm 6059 13 high high JJ cord-023095-4dannjjm 6059 14 absorbers absorber NNS cord-023095-4dannjjm 6059 15 and and CC cord-023095-4dannjjm 6059 16 two two CD cord-023095-4dannjjm 6059 17 low low JJ cord-023095-4dannjjm 6059 18 absorbers absorber NNS cord-023095-4dannjjm 6059 19 were be VBD cord-023095-4dannjjm 6059 20 administered administer VBN cord-023095-4dannjjm 6059 21 an an DT cord-023095-4dannjjm 6059 22 additional additional JJ cord-023095-4dannjjm 6059 23 oral oral JJ cord-023095-4dannjjm 6059 24 dose dose NN cord-023095-4dannjjm 6059 25 as as IN cord-023095-4dannjjm 6059 26 a a DT cord-023095-4dannjjm 6059 27 10 10 CD cord-023095-4dannjjm 6059 28 mg mg NNP cord-023095-4dannjjm 6059 29 / / SYM cord-023095-4dannjjm 6059 30 mL ml NN cord-023095-4dannjjm 6059 31 solution solution NN cord-023095-4dannjjm 6059 32 ( ( -LRB- cord-023095-4dannjjm 6059 33 250 250 CD cord-023095-4dannjjm 6059 34 mg mg NN cord-023095-4dannjjm 6059 35 total total JJ cord-023095-4dannjjm 6059 36 dose dose NN cord-023095-4dannjjm 6059 37 ) ) -RRB- cord-023095-4dannjjm 6059 38 via via IN cord-023095-4dannjjm 6059 39 gastric gastric JJ cord-023095-4dannjjm 6059 40 tube tube NN cord-023095-4dannjjm 6059 41 . . . cord-023095-4dannjjm 6060 1 After after IN cord-023095-4dannjjm 6060 2 administration administration NN cord-023095-4dannjjm 6060 3 of of IN cord-023095-4dannjjm 6060 4 the the DT cord-023095-4dannjjm 6060 5 oral oral JJ cord-023095-4dannjjm 6060 6 solution solution NN cord-023095-4dannjjm 6060 7 , , , cord-023095-4dannjjm 6060 8 the the DT cord-023095-4dannjjm 6060 9 plasma plasma NN cord-023095-4dannjjm 6060 10 concentrations concentration NNS cord-023095-4dannjjm 6060 11 were be VBD cord-023095-4dannjjm 6060 12 more more RBR cord-023095-4dannjjm 6060 13 uniform uniform JJ cord-023095-4dannjjm 6060 14 and and CC cord-023095-4dannjjm 6060 15 consistent consistent JJ cord-023095-4dannjjm 6060 16 among among IN cord-023095-4dannjjm 6060 17 dogs dog NNS cord-023095-4dannjjm 6060 18 . . . cord-023095-4dannjjm 6061 1 Absorption absorption NN cord-023095-4dannjjm 6061 2 of of IN cord-023095-4dannjjm 6061 3 the the DT cord-023095-4dannjjm 6061 4 oral oral JJ cord-023095-4dannjjm 6061 5 solution solution NN cord-023095-4dannjjm 6061 6 of of IN cord-023095-4dannjjm 6061 7 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 6061 8 was be VBD cord-023095-4dannjjm 6061 9 71.0 71.0 CD cord-023095-4dannjjm 6061 10 % % NN cord-023095-4dannjjm 6061 11 ( ( -LRB- cord-023095-4dannjjm 6061 12 CV CV NNP cord-023095-4dannjjm 6061 13 7 7 CD cord-023095-4dannjjm 6061 14 % % NN cord-023095-4dannjjm 6061 15 ) ) -RRB- cord-023095-4dannjjm 6061 16 with with IN cord-023095-4dannjjm 6061 17 a a DT cord-023095-4dannjjm 6061 18 t1/2 t1/2 NN cord-023095-4dannjjm 6061 19 of of IN cord-023095-4dannjjm 6061 20 3.1 3.1 CD cord-023095-4dannjjm 6061 21 ( ( -LRB- cord-023095-4dannjjm 6061 22 CV cv NN cord-023095-4dannjjm 6061 23 18.6 18.6 CD cord-023095-4dannjjm 6061 24 % % NN cord-023095-4dannjjm 6061 25 ) ) -RRB- cord-023095-4dannjjm 6061 26 hr hr NN cord-023095-4dannjjm 6061 27 and and CC cord-023095-4dannjjm 6061 28 C C NNP cord-023095-4dannjjm 6061 29 MAX MAX NNP cord-023095-4dannjjm 6061 30 of of IN cord-023095-4dannjjm 6061 31 4.67 4.67 CD cord-023095-4dannjjm 6061 32 mg mg NNP cord-023095-4dannjjm 6061 33 / / SYM cord-023095-4dannjjm 6061 34 mL ml NN cord-023095-4dannjjm 6062 1 ( ( -LRB- cord-023095-4dannjjm 6062 2 CV cv NN cord-023095-4dannjjm 6062 3 17.6 17.6 CD cord-023095-4dannjjm 6062 4 % % NN cord-023095-4dannjjm 6062 5 ) ) -RRB- cord-023095-4dannjjm 6062 6 . . . cord-023095-4dannjjm 6063 1 Therefore therefore RB cord-023095-4dannjjm 6063 2 , , , cord-023095-4dannjjm 6063 3 it -PRON- PRP cord-023095-4dannjjm 6063 4 appears appear VBZ cord-023095-4dannjjm 6063 5 that that DT cord-023095-4dannjjm 6063 6 inconsistent inconsistent JJ cord-023095-4dannjjm 6063 7 oral oral JJ cord-023095-4dannjjm 6063 8 absorption absorption NN cord-023095-4dannjjm 6063 9 of of IN cord-023095-4dannjjm 6063 10 ciprofloxacin ciprofloxacin NN cord-023095-4dannjjm 6063 11 in in IN cord-023095-4dannjjm 6063 12 some some DT cord-023095-4dannjjm 6063 13 dogs dog NNS cord-023095-4dannjjm 6063 14 may may MD cord-023095-4dannjjm 6063 15 be be VB cord-023095-4dannjjm 6063 16 formulation formulation NN cord-023095-4dannjjm 6063 17 - - HYPH cord-023095-4dannjjm 6063 18 dependent dependent JJ cord-023095-4dannjjm 6063 19 , , , cord-023095-4dannjjm 6063 20 and and CC cord-023095-4dannjjm 6063 21 affected affect VBN cord-023095-4dannjjm 6063 22 by by IN cord-023095-4dannjjm 6063 23 tablet tablet NN cord-023095-4dannjjm 6063 24 dissolution dissolution NN cord-023095-4dannjjm 6063 25 in in IN cord-023095-4dannjjm 6063 26 the the DT cord-023095-4dannjjm 6063 27 canine canine JJ cord-023095-4dannjjm 6063 28 small small JJ cord-023095-4dannjjm 6063 29 intestine intestine NN cord-023095-4dannjjm 6063 30 . . . cord-023095-4dannjjm 6064 1 Doses dose NNS cord-023095-4dannjjm 6064 2 were be VBD cord-023095-4dannjjm 6064 3 calculated calculate VBN cord-023095-4dannjjm 6064 4 using use VBG cord-023095-4dannjjm 6064 5 the the DT cord-023095-4dannjjm 6064 6 data datum NNS cord-023095-4dannjjm 6064 7 for for IN cord-023095-4dannjjm 6064 8 oral oral JJ cord-023095-4dannjjm 6064 9 tablets tablet NNS cord-023095-4dannjjm 6064 10 in in IN cord-023095-4dannjjm 6064 11 these these DT cord-023095-4dannjjm 6064 12 dogs dog NNS cord-023095-4dannjjm 6064 13 . . . cord-023095-4dannjjm 6065 1 The the DT cord-023095-4dannjjm 6065 2 pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 6065 3 - - HYPH cord-023095-4dannjjm 6065 4 pharmacodynamic pharmacodynamic JJ cord-023095-4dannjjm 6065 5 ( ( -LRB- cord-023095-4dannjjm 6065 6 PK PK NNP cord-023095-4dannjjm 6065 7 - - HYPH cord-023095-4dannjjm 6065 8 PD PD NNP cord-023095-4dannjjm 6065 9 ) ) -RRB- cord-023095-4dannjjm 6065 10 target target NN cord-023095-4dannjjm 6065 11 was be VBD cord-023095-4dannjjm 6065 12 an an DT cord-023095-4dannjjm 6065 13 AUC/ auc/ JJ cord-023095-4dannjjm 6065 14 MIC MIC NNP cord-023095-4dannjjm 6065 15 ratio ratio NN cord-023095-4dannjjm 6065 16 of of IN cord-023095-4dannjjm 6065 17 100 100 CD cord-023095-4dannjjm 6065 18 . . . cord-023095-4dannjjm 6066 1 Because because IN cord-023095-4dannjjm 6066 2 of of IN cord-023095-4dannjjm 6066 3 the the DT cord-023095-4dannjjm 6066 4 wide wide JJ cord-023095-4dannjjm 6066 5 range range NN cord-023095-4dannjjm 6066 6 in in IN cord-023095-4dannjjm 6066 7 oral oral JJ cord-023095-4dannjjm 6066 8 absorption absorption NN cord-023095-4dannjjm 6066 9 of of IN cord-023095-4dannjjm 6066 10 tablets tablet NNS cord-023095-4dannjjm 6066 11 , , , cord-023095-4dannjjm 6066 12 a a DT cord-023095-4dannjjm 6066 13 dose dose NN cord-023095-4dannjjm 6066 14 to to TO cord-023095-4dannjjm 6066 15 reach reach VB cord-023095-4dannjjm 6066 16 the the DT cord-023095-4dannjjm 6066 17 PK PK NNP cord-023095-4dannjjm 6066 18 - - HYPH cord-023095-4dannjjm 6066 19 PD PD NNP cord-023095-4dannjjm 6066 20 target target NN cord-023095-4dannjjm 6066 21 ranged range VBN cord-023095-4dannjjm 6066 22 from from IN cord-023095-4dannjjm 6066 23 Canine canine JJ cord-023095-4dannjjm 6066 24 distemper distemper NN cord-023095-4dannjjm 6066 25 ( ( -LRB- cord-023095-4dannjjm 6066 26 CD CD NNP cord-023095-4dannjjm 6066 27 ) ) -RRB- cord-023095-4dannjjm 6066 28 is be VBZ cord-023095-4dannjjm 6066 29 a a DT cord-023095-4dannjjm 6066 30 highly highly RB cord-023095-4dannjjm 6066 31 contagious contagious JJ cord-023095-4dannjjm 6066 32 , , , cord-023095-4dannjjm 6066 33 acute acute JJ cord-023095-4dannjjm 6066 34 or or CC cord-023095-4dannjjm 6066 35 subacute subacute JJ cord-023095-4dannjjm 6066 36 systemic systemic JJ cord-023095-4dannjjm 6066 37 viral viral JJ cord-023095-4dannjjm 6066 38 disease disease NN cord-023095-4dannjjm 6066 39 of of IN cord-023095-4dannjjm 6066 40 dogs dog NNS cord-023095-4dannjjm 6066 41 and and CC cord-023095-4dannjjm 6066 42 other other JJ cord-023095-4dannjjm 6066 43 carnivores carnivore NNS cord-023095-4dannjjm 6066 44 which which WDT cord-023095-4dannjjm 6066 45 can can MD cord-023095-4dannjjm 6066 46 be be VB cord-023095-4dannjjm 6066 47 controlled control VBN cord-023095-4dannjjm 6066 48 efficiently efficiently RB cord-023095-4dannjjm 6066 49 by by IN cord-023095-4dannjjm 6066 50 the the DT cord-023095-4dannjjm 6066 51 use use NN cord-023095-4dannjjm 6066 52 of of IN cord-023095-4dannjjm 6066 53 modified modify VBN cord-023095-4dannjjm 6066 54 live live NN cord-023095-4dannjjm 6066 55 - - HYPH cord-023095-4dannjjm 6066 56 virus virus NN cord-023095-4dannjjm 6066 57 ( ( -LRB- cord-023095-4dannjjm 6066 58 MLV MLV NNP cord-023095-4dannjjm 6066 59 ) ) -RRB- cord-023095-4dannjjm 6066 60 vaccines vaccine NNS cord-023095-4dannjjm 6066 61 . . . cord-023095-4dannjjm 6067 1 However however RB cord-023095-4dannjjm 6067 2 , , , cord-023095-4dannjjm 6067 3 MLV MLV NNP cord-023095-4dannjjm 6067 4 strains strain NNS cord-023095-4dannjjm 6067 5 do do VBP cord-023095-4dannjjm 6067 6 cross cross NN cord-023095-4dannjjm 6067 7 - - VB cord-023095-4dannjjm 6067 8 react react VB cord-023095-4dannjjm 6067 9 with with IN cord-023095-4dannjjm 6067 10 molecular molecular JJ cord-023095-4dannjjm 6067 11 diagnostic diagnostic JJ cord-023095-4dannjjm 6067 12 tests test NNS cord-023095-4dannjjm 6067 13 and and CC cord-023095-4dannjjm 6067 14 cause cause VB cord-023095-4dannjjm 6067 15 significant significant JJ cord-023095-4dannjjm 6067 16 confusion confusion NN cord-023095-4dannjjm 6067 17 for for IN cord-023095-4dannjjm 6067 18 clinicians clinician NNS cord-023095-4dannjjm 6067 19 . . . cord-023095-4dannjjm 6068 1 The the DT cord-023095-4dannjjm 6068 2 purpose purpose NN cord-023095-4dannjjm 6068 3 of of IN cord-023095-4dannjjm 6068 4 this this DT cord-023095-4dannjjm 6068 5 study study NN cord-023095-4dannjjm 6068 6 was be VBD cord-023095-4dannjjm 6068 7 to to TO cord-023095-4dannjjm 6068 8 use use VB cord-023095-4dannjjm 6068 9 quantitative quantitative JJ cord-023095-4dannjjm 6068 10 real real JJ cord-023095-4dannjjm 6068 11 - - HYPH cord-023095-4dannjjm 6068 12 time time NN cord-023095-4dannjjm 6068 13 PCR PCR NNP cord-023095-4dannjjm 6068 14 viral viral JJ cord-023095-4dannjjm 6068 15 load load NN cord-023095-4dannjjm 6068 16 information information NN cord-023095-4dannjjm 6068 17 to to TO cord-023095-4dannjjm 6068 18 differentiate differentiate VB cord-023095-4dannjjm 6068 19 between between IN cord-023095-4dannjjm 6068 20 vaccine vaccine NN cord-023095-4dannjjm 6068 21 virus virus NN cord-023095-4dannjjm 6068 22 used use VBN cord-023095-4dannjjm 6068 23 in in IN cord-023095-4dannjjm 6068 24 MLV MLV NNP cord-023095-4dannjjm 6068 25 vaccines vaccine NNS cord-023095-4dannjjm 6068 26 and and CC cord-023095-4dannjjm 6068 27 wildtype wildtype JJ cord-023095-4dannjjm 6068 28 infections infection NNS cord-023095-4dannjjm 6068 29 in in IN cord-023095-4dannjjm 6068 30 dogs dog NNS cord-023095-4dannjjm 6068 31 . . . cord-023095-4dannjjm 6069 1 A a DT cord-023095-4dannjjm 6069 2 real real JJ cord-023095-4dannjjm 6069 3 - - HYPH cord-023095-4dannjjm 6069 4 time time NN cord-023095-4dannjjm 6069 5 PCR pcr NN cord-023095-4dannjjm 6069 6 test test NN cord-023095-4dannjjm 6069 7 for for IN cord-023095-4dannjjm 6069 8 CD cd NN cord-023095-4dannjjm 6069 9 virus virus NN cord-023095-4dannjjm 6069 10 ( ( -LRB- cord-023095-4dannjjm 6069 11 CDV CDV NNP cord-023095-4dannjjm 6069 12 ) ) -RRB- cord-023095-4dannjjm 6069 13 based base VBN cord-023095-4dannjjm 6069 14 on on IN cord-023095-4dannjjm 6069 15 the the DT cord-023095-4dannjjm 6069 16 P p NN cord-023095-4dannjjm 6069 17 gene gene NN cord-023095-4dannjjm 6069 18 for for IN cord-023095-4dannjjm 6069 19 phosphoprotein phosphoprotein NN cord-023095-4dannjjm 6069 20 was be VBD cord-023095-4dannjjm 6069 21 used use VBN cord-023095-4dannjjm 6069 22 to to TO cord-023095-4dannjjm 6069 23 determine determine VB cord-023095-4dannjjm 6069 24 viral viral JJ cord-023095-4dannjjm 6069 25 loads load NNS cord-023095-4dannjjm 6069 26 in in IN cord-023095-4dannjjm 6069 27 vaccinated vaccinated JJ cord-023095-4dannjjm 6069 28 and and CC cord-023095-4dannjjm 6069 29 wildtype wildtype JJ cord-023095-4dannjjm 6069 30 infected infected JJ cord-023095-4dannjjm 6069 31 animals animal NNS cord-023095-4dannjjm 6069 32 . . . cord-023095-4dannjjm 6070 1 A a DT cord-023095-4dannjjm 6070 2 total total NN cord-023095-4dannjjm 6070 3 of of IN cord-023095-4dannjjm 6070 4 158 158 CD cord-023095-4dannjjm 6070 5 respiratory respiratory JJ cord-023095-4dannjjm 6070 6 mucosal mucosal JJ cord-023095-4dannjjm 6070 7 swab swab NN cord-023095-4dannjjm 6070 8 samples sample NNS cord-023095-4dannjjm 6070 9 from from IN cord-023095-4dannjjm 6070 10 MLV MLV NNP cord-023095-4dannjjm 6070 11 vaccinated vaccinated JJ cord-023095-4dannjjm 6070 12 and and CC cord-023095-4dannjjm 6070 13 asymptomatic asymptomatic JJ cord-023095-4dannjjm 6070 14 dogs dog NNS cord-023095-4dannjjm 6070 15 were be VBD cord-023095-4dannjjm 6070 16 obtained obtain VBN cord-023095-4dannjjm 6070 17 within within IN cord-023095-4dannjjm 6070 18 the the DT cord-023095-4dannjjm 6070 19 first first JJ cord-023095-4dannjjm 6070 20 3 3 CD cord-023095-4dannjjm 6070 21 weeks week NNS cord-023095-4dannjjm 6070 22 after after IN cord-023095-4dannjjm 6070 23 MLV MLV NNP cord-023095-4dannjjm 6070 24 vaccination vaccination NN cord-023095-4dannjjm 6070 25 . . . cord-023095-4dannjjm 6071 1 Based base VBN cord-023095-4dannjjm 6071 2 on on IN cord-023095-4dannjjm 6071 3 the the DT cord-023095-4dannjjm 6071 4 viral viral JJ cord-023095-4dannjjm 6071 5 load load NN cord-023095-4dannjjm 6071 6 in in IN cord-023095-4dannjjm 6071 7 vaccinated vaccinate VBN cord-023095-4dannjjm 6071 8 animals animal NNS cord-023095-4dannjjm 6071 9 , , , cord-023095-4dannjjm 6071 10 a a DT cord-023095-4dannjjm 6071 11 cutoff cutoff NN cord-023095-4dannjjm 6071 12 value value NN cord-023095-4dannjjm 6071 13 was be VBD cord-023095-4dannjjm 6071 14 established establish VBN cord-023095-4dannjjm 6071 15 for for IN cord-023095-4dannjjm 6071 16 the the DT cord-023095-4dannjjm 6071 17 differentiation differentiation NN cord-023095-4dannjjm 6071 18 of of IN cord-023095-4dannjjm 6071 19 dogs dog NNS cord-023095-4dannjjm 6071 20 with with IN cord-023095-4dannjjm 6071 21 clinical clinical JJ cord-023095-4dannjjm 6071 22 signs sign NNS cord-023095-4dannjjm 6071 23 of of IN cord-023095-4dannjjm 6071 24 respiratory respiratory JJ cord-023095-4dannjjm 6071 25 distress distress NN cord-023095-4dannjjm 6071 26 and and CC cord-023095-4dannjjm 6071 27 presumably presumably RB cord-023095-4dannjjm 6071 28 infected infect VBN cord-023095-4dannjjm 6071 29 with with IN cord-023095-4dannjjm 6071 30 a a DT cord-023095-4dannjjm 6071 31 wildtype wildtype JJ cord-023095-4dannjjm 6071 32 strain strain NN cord-023095-4dannjjm 6071 33 of of IN cord-023095-4dannjjm 6071 34 CDV CDV NNP cord-023095-4dannjjm 6071 35 . . . cord-023095-4dannjjm 6072 1 Two two CD cord-023095-4dannjjm 6072 2 hundred hundred CD cord-023095-4dannjjm 6072 3 clinical clinical JJ cord-023095-4dannjjm 6072 4 cases case NNS cord-023095-4dannjjm 6072 5 with with IN cord-023095-4dannjjm 6072 6 known know VBN cord-023095-4dannjjm 6072 7 clinical clinical JJ cord-023095-4dannjjm 6072 8 and and CC cord-023095-4dannjjm 6072 9 vaccination vaccination NN cord-023095-4dannjjm 6072 10 histories history NNS cord-023095-4dannjjm 6072 11 were be VBD cord-023095-4dannjjm 6072 12 analyzed analyze VBN cord-023095-4dannjjm 6072 13 to to TO cord-023095-4dannjjm 6072 14 validate validate VB cord-023095-4dannjjm 6072 15 the the DT cord-023095-4dannjjm 6072 16 cutoff cutoff NN cord-023095-4dannjjm 6072 17 value value NN cord-023095-4dannjjm 6072 18 . . . cord-023095-4dannjjm 6073 1 The the DT cord-023095-4dannjjm 6073 2 CDV CDV NNP cord-023095-4dannjjm 6073 3 real real JJ cord-023095-4dannjjm 6073 4 - - HYPH cord-023095-4dannjjm 6073 5 time time NN cord-023095-4dannjjm 6073 6 PCR PCR NNP cord-023095-4dannjjm 6073 7 proved prove VBD cord-023095-4dannjjm 6073 8 to to TO cord-023095-4dannjjm 6073 9 be be VB cord-023095-4dannjjm 6073 10 of of IN cord-023095-4dannjjm 6073 11 high high JJ cord-023095-4dannjjm 6073 12 analytical analytical JJ cord-023095-4dannjjm 6073 13 and and CC cord-023095-4dannjjm 6073 14 diagnostic diagnostic JJ cord-023095-4dannjjm 6073 15 sensitivity sensitivity NN cord-023095-4dannjjm 6073 16 : : : cord-023095-4dannjjm 6073 17 A a DT cord-023095-4dannjjm 6073 18 standard standard JJ cord-023095-4dannjjm 6073 19 curve curve NN cord-023095-4dannjjm 6073 20 was be VBD cord-023095-4dannjjm 6073 21 established establish VBN cord-023095-4dannjjm 6073 22 using use VBG cord-023095-4dannjjm 6073 23 known know VBN cord-023095-4dannjjm 6073 24 numbers number NNS cord-023095-4dannjjm 6073 25 of of IN cord-023095-4dannjjm 6073 26 CDV CDV NNP cord-023095-4dannjjm 6073 27 molecules molecule NNS cord-023095-4dannjjm 6073 28 to to TO cord-023095-4dannjjm 6073 29 allow allow VB cord-023095-4dannjjm 6073 30 absolute absolute JJ cord-023095-4dannjjm 6073 31 quantitative quantitative JJ cord-023095-4dannjjm 6073 32 CDV CDV NNP cord-023095-4dannjjm 6073 33 viral viral JJ cord-023095-4dannjjm 6073 34 load load NN cord-023095-4dannjjm 6073 35 data datum NNS cord-023095-4dannjjm 6073 36 . . . cord-023095-4dannjjm 6074 1 The the DT cord-023095-4dannjjm 6074 2 limit limit NN cord-023095-4dannjjm 6074 3 of of IN cord-023095-4dannjjm 6074 4 detection detection NN cord-023095-4dannjjm 6074 5 was be VBD cord-023095-4dannjjm 6074 6 in in IN cord-023095-4dannjjm 6074 7 the the DT cord-023095-4dannjjm 6074 8 single single JJ cord-023095-4dannjjm 6074 9 molecule molecule NN cord-023095-4dannjjm 6074 10 range range NN cord-023095-4dannjjm 6074 11 while while IN cord-023095-4dannjjm 6074 12 the the DT cord-023095-4dannjjm 6074 13 limit limit NN cord-023095-4dannjjm 6074 14 of of IN cord-023095-4dannjjm 6074 15 quantitation quantitation NN cord-023095-4dannjjm 6074 16 was be VBD cord-023095-4dannjjm 6074 17 established establish VBN cord-023095-4dannjjm 6074 18 at at IN cord-023095-4dannjjm 6074 19 around around RB cord-023095-4dannjjm 6074 20 10 10 CD cord-023095-4dannjjm 6074 21 molecules molecule NNS cord-023095-4dannjjm 6074 22 per per IN cord-023095-4dannjjm 6074 23 PCR PCR NNP cord-023095-4dannjjm 6074 24 reaction reaction NN cord-023095-4dannjjm 6074 25 . . . cord-023095-4dannjjm 6075 1 A a DT cord-023095-4dannjjm 6075 2 comparison comparison NN cord-023095-4dannjjm 6075 3 to to IN cord-023095-4dannjjm 6075 4 IFA IFA NNP cord-023095-4dannjjm 6075 5 showed show VBD cord-023095-4dannjjm 6075 6 real real JJ cord-023095-4dannjjm 6075 7 - - HYPH cord-023095-4dannjjm 6075 8 time time NN cord-023095-4dannjjm 6075 9 PCR PCR NNP cord-023095-4dannjjm 6075 10 to to TO cord-023095-4dannjjm 6075 11 be be VB cord-023095-4dannjjm 6075 12 30 30 CD cord-023095-4dannjjm 6075 13 % % NN cord-023095-4dannjjm 6075 14 more more RBR cord-023095-4dannjjm 6075 15 sensitive sensitive JJ cord-023095-4dannjjm 6075 16 . . . cord-023095-4dannjjm 6076 1 The the DT cord-023095-4dannjjm 6076 2 CDV CDV NNP cord-023095-4dannjjm 6076 3 viral viral JJ cord-023095-4dannjjm 6076 4 load load NN cord-023095-4dannjjm 6076 5 in in IN cord-023095-4dannjjm 6076 6 vaccinated vaccinate VBN cord-023095-4dannjjm 6076 7 animals animal NNS cord-023095-4dannjjm 6076 8 averaged average VBD cord-023095-4dannjjm 6076 9 26,738 26,738 CD cord-023095-4dannjjm 6076 10 viral viral JJ cord-023095-4dannjjm 6076 11 particles particle NNS cord-023095-4dannjjm 6076 12 per per IN cord-023095-4dannjjm 6076 13 swab swab NN cord-023095-4dannjjm 6076 14 . . . cord-023095-4dannjjm 6077 1 A a DT cord-023095-4dannjjm 6077 2 cutoff cutoff NN cord-023095-4dannjjm 6077 3 value value NN cord-023095-4dannjjm 6077 4 of of IN cord-023095-4dannjjm 6077 5 107,903 107,903 CD cord-023095-4dannjjm 6077 6 viral viral JJ cord-023095-4dannjjm 6077 7 particles particle NNS cord-023095-4dannjjm 6077 8 was be VBD cord-023095-4dannjjm 6077 9 calculated calculate VBN cord-023095-4dannjjm 6077 10 by by IN cord-023095-4dannjjm 6077 11 adding add VBG cord-023095-4dannjjm 6077 12 3 3 CD cord-023095-4dannjjm 6077 13 standard standard JJ cord-023095-4dannjjm 6077 14 deviations deviation NNS cord-023095-4dannjjm 6077 15 to to IN cord-023095-4dannjjm 6077 16 the the DT cord-023095-4dannjjm 6077 17 average average JJ cord-023095-4dannjjm 6077 18 value value NN cord-023095-4dannjjm 6077 19 . . . cord-023095-4dannjjm 6078 1 This this DT cord-023095-4dannjjm 6078 2 cutoff cutoff NN cord-023095-4dannjjm 6078 3 value value NN cord-023095-4dannjjm 6078 4 correctly correctly RB cord-023095-4dannjjm 6078 5 detected detect VBD cord-023095-4dannjjm 6078 6 95.2 95.2 CD cord-023095-4dannjjm 6078 7 % % NN cord-023095-4dannjjm 6078 8 of of IN cord-023095-4dannjjm 6078 9 the the DT cord-023095-4dannjjm 6078 10 vaccinated vaccinate VBN cord-023095-4dannjjm 6078 11 samples sample NNS cord-023095-4dannjjm 6078 12 . . . cord-023095-4dannjjm 6079 1 Acutely acutely RB cord-023095-4dannjjm 6079 2 infected infected JJ cord-023095-4dannjjm 6079 3 dogs dog NNS cord-023095-4dannjjm 6079 4 with with IN cord-023095-4dannjjm 6079 5 CDV CDV NNP cord-023095-4dannjjm 6079 6 compatible compatible JJ cord-023095-4dannjjm 6079 7 clinical clinical JJ cord-023095-4dannjjm 6079 8 signs sign NNS cord-023095-4dannjjm 6079 9 have have VBP cord-023095-4dannjjm 6079 10 high high JJ cord-023095-4dannjjm 6079 11 viral viral JJ cord-023095-4dannjjm 6079 12 loads load NNS cord-023095-4dannjjm 6079 13 normally normally RB cord-023095-4dannjjm 6079 14 several several JJ cord-023095-4dannjjm 6079 15 logs log NNS cord-023095-4dannjjm 6079 16 higher high JJR cord-023095-4dannjjm 6079 17 than than IN cord-023095-4dannjjm 6079 18 the the DT cord-023095-4dannjjm 6079 19 cutoff cutoff NN cord-023095-4dannjjm 6079 20 value value NN cord-023095-4dannjjm 6079 21 . . . cord-023095-4dannjjm 6080 1 In in IN cord-023095-4dannjjm 6080 2 dogs dog NNS cord-023095-4dannjjm 6080 3 with with IN cord-023095-4dannjjm 6080 4 clinical clinical JJ cord-023095-4dannjjm 6080 5 distress distress NN cord-023095-4dannjjm 6080 6 , , , cord-023095-4dannjjm 6080 7 recent recent JJ cord-023095-4dannjjm 6080 8 CDV CDV NNP cord-023095-4dannjjm 6080 9 MLV MLV NNP cord-023095-4dannjjm 6080 10 vaccination vaccination NN cord-023095-4dannjjm 6080 11 but but CC cord-023095-4dannjjm 6080 12 viral viral JJ cord-023095-4dannjjm 6080 13 loads load NNS cord-023095-4dannjjm 6080 14 below below IN cord-023095-4dannjjm 6080 15 the the DT cord-023095-4dannjjm 6080 16 cutoff cutoff NN cord-023095-4dannjjm 6080 17 value value NN cord-023095-4dannjjm 6080 18 , , , cord-023095-4dannjjm 6080 19 other other JJ cord-023095-4dannjjm 6080 20 infectious infectious JJ cord-023095-4dannjjm 6080 21 agents agent NNS cord-023095-4dannjjm 6080 22 were be VBD cord-023095-4dannjjm 6080 23 detected detect VBN cord-023095-4dannjjm 6080 24 by by IN cord-023095-4dannjjm 6080 25 using use VBG cord-023095-4dannjjm 6080 26 a a DT cord-023095-4dannjjm 6080 27 panel panel NN cord-023095-4dannjjm 6080 28 of of IN cord-023095-4dannjjm 6080 29 real real JJ cord-023095-4dannjjm 6080 30 - - HYPH cord-023095-4dannjjm 6080 31 time time NN cord-023095-4dannjjm 6080 32 PCR PCR NNP cord-023095-4dannjjm 6080 33 tests test NNS cord-023095-4dannjjm 6080 34 . . . cord-023095-4dannjjm 6081 1 Testing test VBG cord-023095-4dannjjm 6081 2 additional additional JJ cord-023095-4dannjjm 6081 3 infectious infectious JJ cord-023095-4dannjjm 6081 4 agents agent NNS cord-023095-4dannjjm 6081 5 in in IN cord-023095-4dannjjm 6081 6 clinical clinical JJ cord-023095-4dannjjm 6081 7 settings setting NNS cord-023095-4dannjjm 6081 8 is be VBZ cord-023095-4dannjjm 6081 9 important important JJ cord-023095-4dannjjm 6081 10 in in IN cord-023095-4dannjjm 6081 11 order order NN cord-023095-4dannjjm 6081 12 to to TO cord-023095-4dannjjm 6081 13 explain explain VB cord-023095-4dannjjm 6081 14 clinical clinical JJ cord-023095-4dannjjm 6081 15 signs sign NNS cord-023095-4dannjjm 6081 16 when when WRB cord-023095-4dannjjm 6081 17 viral viral JJ cord-023095-4dannjjm 6081 18 loads load NNS cord-023095-4dannjjm 6081 19 below below IN cord-023095-4dannjjm 6081 20 cutoff cutoff NN cord-023095-4dannjjm 6081 21 values value NNS cord-023095-4dannjjm 6081 22 indicate indicate VBP cord-023095-4dannjjm 6081 23 that that IN cord-023095-4dannjjm 6081 24 CDV CDV NNP cord-023095-4dannjjm 6081 25 is be VBZ cord-023095-4dannjjm 6081 26 not not RB cord-023095-4dannjjm 6081 27 the the DT cord-023095-4dannjjm 6081 28 cause cause NN cord-023095-4dannjjm 6081 29 of of IN cord-023095-4dannjjm 6081 30 clinical clinical JJ cord-023095-4dannjjm 6081 31 signs sign NNS cord-023095-4dannjjm 6081 32 . . . cord-023095-4dannjjm 6082 1 In in IN cord-023095-4dannjjm 6082 2 conclusion conclusion NN cord-023095-4dannjjm 6082 3 , , , cord-023095-4dannjjm 6082 4 quantitative quantitative JJ cord-023095-4dannjjm 6082 5 real real JJ cord-023095-4dannjjm 6082 6 - - HYPH cord-023095-4dannjjm 6082 7 time time NN cord-023095-4dannjjm 6082 8 PCR PCR NNP cord-023095-4dannjjm 6082 9 is be VBZ cord-023095-4dannjjm 6082 10 a a DT cord-023095-4dannjjm 6082 11 sensitive sensitive JJ cord-023095-4dannjjm 6082 12 , , , cord-023095-4dannjjm 6082 13 rapid rapid JJ cord-023095-4dannjjm 6082 14 and and CC cord-023095-4dannjjm 6082 15 reliable reliable JJ cord-023095-4dannjjm 6082 16 test test NN cord-023095-4dannjjm 6082 17 regardless regardless RB cord-023095-4dannjjm 6082 18 of of IN cord-023095-4dannjjm 6082 19 recent recent JJ cord-023095-4dannjjm 6082 20 vaccination vaccination NN cord-023095-4dannjjm 6082 21 . . . cord-023095-4dannjjm 6083 1 The the DT cord-023095-4dannjjm 6083 2 use use NN cord-023095-4dannjjm 6083 3 of of IN cord-023095-4dannjjm 6083 4 a a DT cord-023095-4dannjjm 6083 5 cutoff cutoff NN cord-023095-4dannjjm 6083 6 value value NN cord-023095-4dannjjm 6083 7 will will MD cord-023095-4dannjjm 6083 8 be be VB cord-023095-4dannjjm 6083 9 of of IN cord-023095-4dannjjm 6083 10 significant significant JJ cord-023095-4dannjjm 6083 11 help help NN cord-023095-4dannjjm 6083 12 to to TO cord-023095-4dannjjm 6083 13 discriminate discriminate VB cord-023095-4dannjjm 6083 14 between between IN cord-023095-4dannjjm 6083 15 vaccine vaccine NN cord-023095-4dannjjm 6083 16 interference interference NN cord-023095-4dannjjm 6083 17 and and CC cord-023095-4dannjjm 6083 18 wildtype wildtype JJ cord-023095-4dannjjm 6083 19 infection infection NN cord-023095-4dannjjm 6083 20 in in IN cord-023095-4dannjjm 6083 21 clinical clinical JJ cord-023095-4dannjjm 6083 22 settings setting NNS cord-023095-4dannjjm 6083 23 . . . cord-023095-4dannjjm 6084 1 Feline feline JJ cord-023095-4dannjjm 6084 2 ureteral ureteral JJ cord-023095-4dannjjm 6084 3 obstructions obstruction NNS cord-023095-4dannjjm 6084 4 are be VBP cord-023095-4dannjjm 6084 5 a a DT cord-023095-4dannjjm 6084 6 common common JJ cord-023095-4dannjjm 6084 7 urinary urinary JJ cord-023095-4dannjjm 6084 8 dilemma dilemma NN cord-023095-4dannjjm 6084 9 and and CC cord-023095-4dannjjm 6084 10 traditional traditional JJ cord-023095-4dannjjm 6084 11 therapy therapy NN cord-023095-4dannjjm 6084 12 is be VBZ cord-023095-4dannjjm 6084 13 associated associate VBN cord-023095-4dannjjm 6084 14 with with IN cord-023095-4dannjjm 6084 15 substantial substantial JJ cord-023095-4dannjjm 6084 16 morbidity morbidity NN cord-023095-4dannjjm 6084 17 / / SYM cord-023095-4dannjjm 6084 18 mortality mortality NN cord-023095-4dannjjm 6084 19 . . . cord-023095-4dannjjm 6085 1 Feline feline JJ cord-023095-4dannjjm 6085 2 nephrostomy nephrostomy JJ cord-023095-4dannjjm 6085 3 tubes tube NNS cord-023095-4dannjjm 6085 4 are be VBP cord-023095-4dannjjm 6085 5 reported report VBN cord-023095-4dannjjm 6085 6 as as IN cord-023095-4dannjjm 6085 7 being be VBG cord-023095-4dannjjm 6085 8 effective effective JJ cord-023095-4dannjjm 6085 9 when when WRB cord-023095-4dannjjm 6085 10 pelvic pelvic JJ cord-023095-4dannjjm 6085 11 drainage drainage NN cord-023095-4dannjjm 6085 12 is be VBZ cord-023095-4dannjjm 6085 13 required require VBN cord-023095-4dannjjm 6085 14 . . . cord-023095-4dannjjm 6086 1 The the DT cord-023095-4dannjjm 6086 2 biggest big JJS cord-023095-4dannjjm 6086 3 limitation limitation NN cord-023095-4dannjjm 6086 4 is be VBZ cord-023095-4dannjjm 6086 5 externalized externalize VBN cord-023095-4dannjjm 6086 6 drainage drainage NN cord-023095-4dannjjm 6086 7 , , , cord-023095-4dannjjm 6086 8 requiring require VBG cord-023095-4dannjjm 6086 9 careful careful JJ cord-023095-4dannjjm 6086 10 management management NN cord-023095-4dannjjm 6086 11 to to TO cord-023095-4dannjjm 6086 12 prevent prevent VB cord-023095-4dannjjm 6086 13 infection infection NN cord-023095-4dannjjm 6086 14 / / SYM cord-023095-4dannjjm 6086 15 dislodgement dislodgement NN cord-023095-4dannjjm 6086 16 . . . cord-023095-4dannjjm 6087 1 The the DT cord-023095-4dannjjm 6087 2 development development NN cord-023095-4dannjjm 6087 3 of of IN cord-023095-4dannjjm 6087 4 an an DT cord-023095-4dannjjm 6087 5 indwelling indwell VBG cord-023095-4dannjjm 6087 6 ureteral ureteral JJ cord-023095-4dannjjm 6087 7 bypass bypass NN cord-023095-4dannjjm 6087 8 using use VBG cord-023095-4dannjjm 6087 9 a a DT cord-023095-4dannjjm 6087 10 combination combination NN cord-023095-4dannjjm 6087 11 locking locking NN cord-023095-4dannjjm 6087 12 - - HYPH cord-023095-4dannjjm 6087 13 loop loop NN cord-023095-4dannjjm 6087 14 nephrostomy nephrostomy NNP cord-023095-4dannjjm 6087 15 / / SYM cord-023095-4dannjjm 6087 16 cystostomy cystostomy NN cord-023095-4dannjjm 6087 17 tube tube NN cord-023095-4dannjjm 6087 18 was be VBD cord-023095-4dannjjm 6087 19 modified modify VBN cord-023095-4dannjjm 6087 20 from from IN cord-023095-4dannjjm 6087 21 humans human NNS cord-023095-4dannjjm 6087 22 , , , cord-023095-4dannjjm 6087 23 resulting result VBG cord-023095-4dannjjm 6087 24 in in IN cord-023095-4dannjjm 6087 25 permanent permanent JJ cord-023095-4dannjjm 6087 26 indwelling indwell VBG cord-023095-4dannjjm 6087 27 drainage drainage NN cord-023095-4dannjjm 6087 28 , , , cord-023095-4dannjjm 6087 29 reduced reduced JJ cord-023095-4dannjjm 6087 30 complications complication NNS cord-023095-4dannjjm 6087 31 , , , cord-023095-4dannjjm 6087 32 and and CC cord-023095-4dannjjm 6087 33 improved improve VBD cord-023095-4dannjjm 6087 34 quality quality NN cord-023095-4dannjjm 6087 35 of of IN cord-023095-4dannjjm 6087 36 life life NN cord-023095-4dannjjm 6087 37 . . . cord-023095-4dannjjm 6088 1 The the DT cord-023095-4dannjjm 6088 2 objective objective NN cord-023095-4dannjjm 6088 3 is be VBZ cord-023095-4dannjjm 6088 4 to to TO cord-023095-4dannjjm 6088 5 describe describe VB cord-023095-4dannjjm 6088 6 the the DT cord-023095-4dannjjm 6088 7 technical technical JJ cord-023095-4dannjjm 6088 8 and and CC cord-023095-4dannjjm 6088 9 clinical clinical JJ cord-023095-4dannjjm 6088 10 outcome outcome NN cord-023095-4dannjjm 6088 11 using use VBG cord-023095-4dannjjm 6088 12 a a DT cord-023095-4dannjjm 6088 13 novel novel JJ cord-023095-4dannjjm 6088 14 device device NN cord-023095-4dannjjm 6088 15 called call VBN cord-023095-4dannjjm 6088 16 a a DT cord-023095-4dannjjm 6088 17 subcutaneous subcutaneous JJ cord-023095-4dannjjm 6088 18 ureteral ureteral JJ cord-023095-4dannjjm 6088 19 bypass bypass NN cord-023095-4dannjjm 6088 20 ( ( -LRB- cord-023095-4dannjjm 6088 21 SUB sub NN cord-023095-4dannjjm 6088 22 ) ) -RRB- cord-023095-4dannjjm 6088 23 in in IN cord-023095-4dannjjm 6088 24 cats cat NNS cord-023095-4dannjjm 6088 25 with with IN cord-023095-4dannjjm 6088 26 ureteral ureteral JJ cord-023095-4dannjjm 6088 27 obstructions obstruction NNS cord-023095-4dannjjm 6088 28 . . . cord-023095-4dannjjm 6089 1 Fifteen fifteen CD cord-023095-4dannjjm 6089 2 cats cat NNS cord-023095-4dannjjm 6089 3 ( ( -LRB- cord-023095-4dannjjm 6089 4 16 16 CD cord-023095-4dannjjm 6089 5 kidneys kidney NNS cord-023095-4dannjjm 6089 6 ) ) -RRB- cord-023095-4dannjjm 6089 7 had have VBD cord-023095-4dannjjm 6089 8 a a DT cord-023095-4dannjjm 6089 9 SUB sub NN cord-023095-4dannjjm 6089 10 placed place VBN cord-023095-4dannjjm 6089 11 for for IN cord-023095-4dannjjm 6089 12 : : : cord-023095-4dannjjm 6089 13 ureterolithiasis ureterolithiasis NNP cord-023095-4dannjjm 6089 14 ( ( -LRB- cord-023095-4dannjjm 6089 15 9 9 CD cord-023095-4dannjjm 6089 16 ) ) -RRB- cord-023095-4dannjjm 6089 17 , , , cord-023095-4dannjjm 6089 18 ureteral ureteral JJ cord-023095-4dannjjm 6089 19 stricture stricture NN cord-023095-4dannjjm 6089 20 ( ( -LRB- cord-023095-4dannjjm 6089 21 1 1 CD cord-023095-4dannjjm 6089 22 / / SYM cord-023095-4dannjjm 6089 23 À à NN cord-023095-4dannjjm 6089 24 stones stone NNS cord-023095-4dannjjm 6089 25 ) ) -RRB- cord-023095-4dannjjm 6089 26 ( ( -LRB- cord-023095-4dannjjm 6089 27 6 6 CD cord-023095-4dannjjm 6089 28 ) ) -RRB- cord-023095-4dannjjm 6089 29 , , , cord-023095-4dannjjm 6089 30 and and CC cord-023095-4dannjjm 6089 31 ureteral ureteral JJ cord-023095-4dannjjm 6089 32 stent stent NN cord-023095-4dannjjm 6089 33 rejection rejection NN cord-023095-4dannjjm 6089 34 ( ( -LRB- cord-023095-4dannjjm 6089 35 2 2 CD cord-023095-4dannjjm 6089 36 ) ) -RRB- cord-023095-4dannjjm 6089 37 . . . cord-023095-4dannjjm 6090 1 The the DT cord-023095-4dannjjm 6090 2 median median JJ cord-023095-4dannjjm 6090 3 pre pre JJ cord-023095-4dannjjm 6090 4 - - JJ cord-023095-4dannjjm 6090 5 and and CC cord-023095-4dannjjm 6090 6 post post JJ cord-023095-4dannjjm 6090 7 - - JJ cord-023095-4dannjjm 6090 8 procedure procedure JJ cord-023095-4dannjjm 6090 9 creatinine creatinine NN cord-023095-4dannjjm 6090 10 was be VBD cord-023095-4dannjjm 6090 11 6 6 CD cord-023095-4dannjjm 6090 12 mg mg NNP cord-023095-4dannjjm 6090 13 / / SYM cord-023095-4dannjjm 6090 14 dL dl NN cord-023095-4dannjjm 6090 15 ( ( -LRB- cord-023095-4dannjjm 6090 16 range range NN cord-023095-4dannjjm 6090 17 : : : cord-023095-4dannjjm 6090 18 2.8 2.8 CD cord-023095-4dannjjm 6090 19 - - SYM cord-023095-4dannjjm 6090 20 13 13 CD cord-023095-4dannjjm 6090 21 ) ) -RRB- cord-023095-4dannjjm 6090 22 and and CC cord-023095-4dannjjm 6090 23 2.5 2.5 CD cord-023095-4dannjjm 6090 24 mg mg NNP cord-023095-4dannjjm 6090 25 / / SYM cord-023095-4dannjjm 6090 26 dL dl NN cord-023095-4dannjjm 6090 27 ( ( -LRB- cord-023095-4dannjjm 6090 28 range range NN cord-023095-4dannjjm 6090 29 : : : cord-023095-4dannjjm 6090 30 2.4 2.4 CD cord-023095-4dannjjm 6090 31 - - SYM cord-023095-4dannjjm 6090 32 9 9 CD cord-023095-4dannjjm 6090 33 ) ) -RRB- cord-023095-4dannjjm 6090 34 , , , cord-023095-4dannjjm 6090 35 respectively respectively RB cord-023095-4dannjjm 6090 36 . . . cord-023095-4dannjjm 6091 1 The the DT cord-023095-4dannjjm 6091 2 median median JJ cord-023095-4dannjjm 6091 3 pelvis pelvi NNS cord-023095-4dannjjm 6091 4 diameter diameter VBP cord-023095-4dannjjm 6091 5 pre pre VB cord-023095-4dannjjm 6091 6 and and CC cord-023095-4dannjjm 6091 7 post post JJ cord-023095-4dannjjm 6091 8 - - NN cord-023095-4dannjjm 6091 9 procedure procedure NN cord-023095-4dannjjm 6091 10 were be VBD cord-023095-4dannjjm 6091 11 15 15 CD cord-023095-4dannjjm 6092 1 ( ( -LRB- cord-023095-4dannjjm 6092 2 range range NN cord-023095-4dannjjm 6092 3 : : : cord-023095-4dannjjm 6092 4 7 7 CD cord-023095-4dannjjm 6092 5 - - SYM cord-023095-4dannjjm 6092 6 28 28 CD cord-023095-4dannjjm 6092 7 ) ) -RRB- cord-023095-4dannjjm 6092 8 and and CC cord-023095-4dannjjm 6092 9 5 5 CD cord-023095-4dannjjm 6092 10 mm mm NN cord-023095-4dannjjm 6092 11 ( ( -LRB- cord-023095-4dannjjm 6092 12 range range NNP cord-023095-4dannjjm 6092 13 3.4 3.4 CD cord-023095-4dannjjm 6092 14 - - SYM cord-023095-4dannjjm 6092 15 6 6 CD cord-023095-4dannjjm 6092 16 ) ) -RRB- cord-023095-4dannjjm 6092 17 , , , cord-023095-4dannjjm 6092 18 respectively respectively RB cord-023095-4dannjjm 6092 19 . . . cord-023095-4dannjjm 6093 1 Six six CD cord-023095-4dannjjm 6093 2 French french JJ cord-023095-4dannjjm 6093 3 tubes tube NNS cord-023095-4dannjjm 6093 4 were be VBD cord-023095-4dannjjm 6093 5 placed place VBN cord-023095-4dannjjm 6093 6 in in IN cord-023095-4dannjjm 6093 7 14 14 CD cord-023095-4dannjjm 6093 8 , , , cord-023095-4dannjjm 6093 9 and and CC cord-023095-4dannjjm 6093 10 5 5 CD cord-023095-4dannjjm 6093 11 Fr fr NN cord-023095-4dannjjm 6093 12 . . . cord-023095-4dannjjm 6094 1 in in IN cord-023095-4dannjjm 6094 2 2 2 CD cord-023095-4dannjjm 6094 3 . . . cord-023095-4dannjjm 6095 1 The the DT cord-023095-4dannjjm 6095 2 bypass bypass NN cord-023095-4dannjjm 6095 3 remained remain VBD cord-023095-4dannjjm 6095 4 indwelling indwell VBG cord-023095-4dannjjm 6095 5 for for IN cord-023095-4dannjjm 6095 6 a a DT cord-023095-4dannjjm 6095 7 median median NN cord-023095-4dannjjm 6095 8 of of IN cord-023095-4dannjjm 6095 9 4240 4240 CD cord-023095-4dannjjm 6095 10 days day NNS cord-023095-4dannjjm 6095 11 ( ( -LRB- cord-023095-4dannjjm 6095 12 range range VBP cord-023095-4dannjjm 6095 13 64 64 CD cord-023095-4dannjjm 6095 14 - - HYPH cord-023095-4dannjjm 6095 15 4450 4450 CD cord-023095-4dannjjm 6095 16 ) ) -RRB- cord-023095-4dannjjm 6095 17 . . . cord-023095-4dannjjm 6096 1 There there EX cord-023095-4dannjjm 6096 2 were be VBD cord-023095-4dannjjm 6096 3 3 3 CD cord-023095-4dannjjm 6096 4 major major JJ cord-023095-4dannjjm 6096 5 complications complication NNS cord-023095-4dannjjm 6096 6 resulting result VBG cord-023095-4dannjjm 6096 7 in in IN cord-023095-4dannjjm 6096 8 nephrostomy nephrostomy JJ cord-023095-4dannjjm 6096 9 tube tube NN cord-023095-4dannjjm 6096 10 dislodgement dislodgement NN cord-023095-4dannjjm 6096 11 ( ( -LRB- cord-023095-4dannjjm 6096 12 2 2 CD cord-023095-4dannjjm 6096 13 ) ) -RRB- cord-023095-4dannjjm 6096 14 and and CC cord-023095-4dannjjm 6096 15 port port NN cord-023095-4dannjjm 6096 16 leakage leakage NN cord-023095-4dannjjm 6096 17 ( ( -LRB- cord-023095-4dannjjm 6096 18 1 1 CD cord-023095-4dannjjm 6096 19 ) ) -RRB- cord-023095-4dannjjm 6096 20 5 5 CD cord-023095-4dannjjm 6096 21 days day NNS cord-023095-4dannjjm 6096 22 after after IN cord-023095-4dannjjm 6096 23 surgery surgery NN cord-023095-4dannjjm 6096 24 . . . cord-023095-4dannjjm 6097 1 One one CD cord-023095-4dannjjm 6097 2 patient patient NN cord-023095-4dannjjm 6097 3 with with IN cord-023095-4dannjjm 6097 4 severe severe JJ cord-023095-4dannjjm 6097 5 coagulopathy coagulopathy NN cord-023095-4dannjjm 6097 6 developed develop VBD cord-023095-4dannjjm 6097 7 a a DT cord-023095-4dannjjm 6097 8 clot clot NN cord-023095-4dannjjm 6097 9 which which WDT cord-023095-4dannjjm 6097 10 resolved resolve VBD cord-023095-4dannjjm 6097 11 with with IN cord-023095-4dannjjm 6097 12 tPA tPA NNP cord-023095-4dannjjm 6097 13 infusion infusion NN cord-023095-4dannjjm 6097 14 through through IN cord-023095-4dannjjm 6097 15 the the DT cord-023095-4dannjjm 6097 16 port port NN cord-023095-4dannjjm 6097 17 . . . cord-023095-4dannjjm 6098 1 No no DT cord-023095-4dannjjm 6098 2 SUB sub NN cord-023095-4dannjjm 6098 3 got get VBD cord-023095-4dannjjm 6098 4 occluded occlude VBN cord-023095-4dannjjm 6098 5 / / SYM cord-023095-4dannjjm 6098 6 obstructed obstruct VBN cord-023095-4dannjjm 6098 7 long long JJ cord-023095-4dannjjm 6098 8 - - HYPH cord-023095-4dannjjm 6098 9 term term NN cord-023095-4dannjjm 6098 10 . . . cord-023095-4dannjjm 6099 1 Overall overall RB cord-023095-4dannjjm 6099 2 , , , cord-023095-4dannjjm 6099 3 the the DT cord-023095-4dannjjm 6099 4 use use NN cord-023095-4dannjjm 6099 5 of of IN cord-023095-4dannjjm 6099 6 a a DT cord-023095-4dannjjm 6099 7 SUB sub NN cord-023095-4dannjjm 6099 8 for for IN cord-023095-4dannjjm 6099 9 cats cat NNS cord-023095-4dannjjm 6099 10 with with IN cord-023095-4dannjjm 6099 11 ureteral ureteral JJ cord-023095-4dannjjm 6099 12 obstructions obstruction NNS cord-023095-4dannjjm 6099 13 can can MD cord-023095-4dannjjm 6099 14 be be VB cord-023095-4dannjjm 6099 15 considered consider VBN cord-023095-4dannjjm 6099 16 a a DT cord-023095-4dannjjm 6099 17 functional functional JJ cord-023095-4dannjjm 6099 18 option option NN cord-023095-4dannjjm 6099 19 when when WRB cord-023095-4dannjjm 6099 20 other other JJ cord-023095-4dannjjm 6099 21 therapies therapy NNS cord-023095-4dannjjm 6099 22 have have VBP cord-023095-4dannjjm 6099 23 failed fail VBN cord-023095-4dannjjm 6099 24 or or CC cord-023095-4dannjjm 6099 25 are be VBP cord-023095-4dannjjm 6099 26 contraindicated contraindicate VBN cord-023095-4dannjjm 6099 27 , , , cord-023095-4dannjjm 6099 28 but but CC cord-023095-4dannjjm 6099 29 shtime shtime NNP cord-023095-4dannjjm 6099 30 . . . cord-023095-4dannjjm 6100 1 Oxidative oxidative JJ cord-023095-4dannjjm 6100 2 stress stress NN cord-023095-4dannjjm 6100 3 is be VBZ cord-023095-4dannjjm 6100 4 considered consider VBN cord-023095-4dannjjm 6100 5 central central JJ cord-023095-4dannjjm 6100 6 to to IN cord-023095-4dannjjm 6100 7 the the DT cord-023095-4dannjjm 6100 8 pathogenesis pathogenesis NN cord-023095-4dannjjm 6100 9 of of IN cord-023095-4dannjjm 6100 10 many many JJ cord-023095-4dannjjm 6100 11 systemic systemic JJ cord-023095-4dannjjm 6100 12 diseases disease NNS cord-023095-4dannjjm 6100 13 . . . cord-023095-4dannjjm 6101 1 In in IN cord-023095-4dannjjm 6101 2 humans human NNS cord-023095-4dannjjm 6101 3 , , , cord-023095-4dannjjm 6101 4 biomarkers biomarker NNS cord-023095-4dannjjm 6101 5 of of IN cord-023095-4dannjjm 6101 6 oxidative oxidative JJ cord-023095-4dannjjm 6101 7 stress stress NN cord-023095-4dannjjm 6101 8 , , , cord-023095-4dannjjm 6101 9 antioxidant antioxidant JJ cord-023095-4dannjjm 6101 10 depletion depletion NN cord-023095-4dannjjm 6101 11 and and CC cord-023095-4dannjjm 6101 12 lipid lipid NN cord-023095-4dannjjm 6101 13 peroxidation peroxidation NN cord-023095-4dannjjm 6101 14 , , , cord-023095-4dannjjm 6101 15 have have VBP cord-023095-4dannjjm 6101 16 been be VBN cord-023095-4dannjjm 6101 17 correlated correlate VBN cord-023095-4dannjjm 6101 18 with with IN cord-023095-4dannjjm 6101 19 disease disease NN cord-023095-4dannjjm 6101 20 severity severity NN cord-023095-4dannjjm 6101 21 and and CC cord-023095-4dannjjm 6101 22 associated associate VBN cord-023095-4dannjjm 6101 23 with with IN cord-023095-4dannjjm 6101 24 poor poor JJ cord-023095-4dannjjm 6101 25 clinical clinical JJ cord-023095-4dannjjm 6101 26 outcomes outcome NNS cord-023095-4dannjjm 6101 27 . . . cord-023095-4dannjjm 6102 1 Therapeutic therapeutic JJ cord-023095-4dannjjm 6102 2 antioxidant antioxidant JJ cord-023095-4dannjjm 6102 3 supplementation supplementation NN cord-023095-4dannjjm 6102 4 with with IN cord-023095-4dannjjm 6102 5 NAC NAC NNP cord-023095-4dannjjm 6102 6 in in IN cord-023095-4dannjjm 6102 7 glutathione glutathione NN cord-023095-4dannjjm 6102 8 ( ( -LRB- cord-023095-4dannjjm 6102 9 GSH)-deficient GSH)-deficient NNP cord-023095-4dannjjm 6102 10 patients patient NNS cord-023095-4dannjjm 6102 11 has have VBZ cord-023095-4dannjjm 6102 12 shown show VBN cord-023095-4dannjjm 6102 13 clinical clinical JJ cord-023095-4dannjjm 6102 14 benefits benefit NNS cord-023095-4dannjjm 6102 15 , , , cord-023095-4dannjjm 6102 16 including include VBG cord-023095-4dannjjm 6102 17 repletion repletion NN cord-023095-4dannjjm 6102 18 of of IN cord-023095-4dannjjm 6102 19 intracellular intracellular JJ cord-023095-4dannjjm 6102 20 GSH GSH NNP cord-023095-4dannjjm 6102 21 levels level NNS cord-023095-4dannjjm 6102 22 . . . cord-023095-4dannjjm 6103 1 We -PRON- PRP cord-023095-4dannjjm 6103 2 have have VBP cord-023095-4dannjjm 6103 3 shown show VBN cord-023095-4dannjjm 6103 4 that that IN cord-023095-4dannjjm 6103 5 clinically clinically RB cord-023095-4dannjjm 6103 6 ill ill JJ cord-023095-4dannjjm 6103 7 dogs dog NNS cord-023095-4dannjjm 6103 8 are be VBP cord-023095-4dannjjm 6103 9 GSH gsh NN cord-023095-4dannjjm 6103 10 - - HYPH cord-023095-4dannjjm 6103 11 deficient deficient JJ cord-023095-4dannjjm 6103 12 , , , cord-023095-4dannjjm 6103 13 and and CC cord-023095-4dannjjm 6103 14 that that IN cord-023095-4dannjjm 6103 15 GSH GSH NNP cord-023095-4dannjjm 6103 16 deficiency deficiency NN cord-023095-4dannjjm 6103 17 correlates correlate VBZ cord-023095-4dannjjm 6103 18 with with IN cord-023095-4dannjjm 6103 19 mortality mortality NN cord-023095-4dannjjm 6103 20 , , , cord-023095-4dannjjm 6103 21 but but CC cord-023095-4dannjjm 6103 22 it -PRON- PRP cord-023095-4dannjjm 6103 23 is be VBZ cord-023095-4dannjjm 6103 24 not not RB cord-023095-4dannjjm 6103 25 clear clear JJ cord-023095-4dannjjm 6103 26 whether whether IN cord-023095-4dannjjm 6103 27 there there EX cord-023095-4dannjjm 6103 28 are be VBP cord-023095-4dannjjm 6103 29 direct direct JJ cord-023095-4dannjjm 6103 30 benefits benefit NNS cord-023095-4dannjjm 6103 31 of of IN cord-023095-4dannjjm 6103 32 antioxidant antioxidant JJ cord-023095-4dannjjm 6103 33 intervention intervention NN cord-023095-4dannjjm 6103 34 in in IN cord-023095-4dannjjm 6103 35 these these DT cord-023095-4dannjjm 6103 36 patients patient NNS cord-023095-4dannjjm 6103 37 . . . cord-023095-4dannjjm 6104 1 The the DT cord-023095-4dannjjm 6104 2 purpose purpose NN cord-023095-4dannjjm 6104 3 of of IN cord-023095-4dannjjm 6104 4 this this DT cord-023095-4dannjjm 6104 5 randomized randomized JJ cord-023095-4dannjjm 6104 6 , , , cord-023095-4dannjjm 6104 7 investigator investigator NN cord-023095-4dannjjm 6104 8 - - HYPH cord-023095-4dannjjm 6104 9 blinded blind VBN cord-023095-4dannjjm 6104 10 , , , cord-023095-4dannjjm 6104 11 placebo placebo NN cord-023095-4dannjjm 6104 12 - - HYPH cord-023095-4dannjjm 6104 13 controlled control VBN cord-023095-4dannjjm 6104 14 , , , cord-023095-4dannjjm 6104 15 prospective prospective JJ cord-023095-4dannjjm 6104 16 study study NN cord-023095-4dannjjm 6104 17 was be VBD cord-023095-4dannjjm 6104 18 to to TO cord-023095-4dannjjm 6104 19 evaluate evaluate VB cord-023095-4dannjjm 6104 20 the the DT cord-023095-4dannjjm 6104 21 effect effect NN cord-023095-4dannjjm 6104 22 of of IN cord-023095-4dannjjm 6104 23 NAC NAC NNP cord-023095-4dannjjm 6104 24 to to TO cord-023095-4dannjjm 6104 25 normalize normalize VB cord-023095-4dannjjm 6104 26 blood blood NN cord-023095-4dannjjm 6104 27 antioxidants antioxidant NNS cord-023095-4dannjjm 6105 1 ( ( -LRB- cord-023095-4dannjjm 6105 2 RBC RBC NNP cord-023095-4dannjjm 6105 3 reduced reduce VBN cord-023095-4dannjjm 6105 4 GSH GSH NNP cord-023095-4dannjjm 6105 5 ( ( -LRB- cord-023095-4dannjjm 6105 6 RBC RBC NNP cord-023095-4dannjjm 6105 7 GSH GSH NNP cord-023095-4dannjjm 6105 8 ) ) -RRB- cord-023095-4dannjjm 6105 9 , , , cord-023095-4dannjjm 6105 10 plasma plasma NN cord-023095-4dannjjm 6105 11 cysteine cysteine NN cord-023095-4dannjjm 6105 12 ( ( -LRB- cord-023095-4dannjjm 6105 13 CYS CYS NNP cord-023095-4dannjjm 6105 14 ) ) -RRB- cord-023095-4dannjjm 6105 15 , , , cord-023095-4dannjjm 6105 16 serum serum NN cord-023095-4dannjjm 6105 17 vitamin vitamin NN cord-023095-4dannjjm 6105 18 E e NN cord-023095-4dannjjm 6105 19 ( ( -LRB- cord-023095-4dannjjm 6105 20 vit vit NNP cord-023095-4dannjjm 6105 21 E E NNP cord-023095-4dannjjm 6105 22 ) ) -RRB- cord-023095-4dannjjm 6105 23 , , , cord-023095-4dannjjm 6105 24 and and CC cord-023095-4dannjjm 6105 25 whole whole JJ cord-023095-4dannjjm 6105 26 blood blood NN cord-023095-4dannjjm 6105 27 selenium selenium NN cord-023095-4dannjjm 6105 28 ( ( -LRB- cord-023095-4dannjjm 6105 29 Se Se NNP cord-023095-4dannjjm 6105 30 ) ) -RRB- cord-023095-4dannjjm 6105 31 ) ) -RRB- cord-023095-4dannjjm 6105 32 , , , cord-023095-4dannjjm 6105 33 reduce reduce VB cord-023095-4dannjjm 6105 34 lipid lipid NN cord-023095-4dannjjm 6105 35 peroxidation peroxidation NN cord-023095-4dannjjm 6105 36 ( ( -LRB- cord-023095-4dannjjm 6105 37 urine urine NNP cord-023095-4dannjjm 6105 38 isoprostane isoprostane NNP cord-023095-4dannjjm 6105 39 / / SYM cord-023095-4dannjjm 6105 40 creatinine creatinine NN cord-023095-4dannjjm 6105 41 ratio ratio NN cord-023095-4dannjjm 6105 42 ( ( -LRB- cord-023095-4dannjjm 6105 43 U U NNP cord-023095-4dannjjm 6105 44 I/ I/ NNP cord-023095-4dannjjm 6105 45 C C NNP cord-023095-4dannjjm 6105 46 ) ) -RRB- cord-023095-4dannjjm 6105 47 ) ) -RRB- cord-023095-4dannjjm 6105 48 , , , cord-023095-4dannjjm 6105 49 and and CC cord-023095-4dannjjm 6105 50 improve improve VB cord-023095-4dannjjm 6105 51 illness illness NN cord-023095-4dannjjm 6105 52 scores score NNS cord-023095-4dannjjm 6105 53 ( ( -LRB- cord-023095-4dannjjm 6105 54 SPI2 SPI2 NNP cord-023095-4dannjjm 6105 55 ) ) -RRB- cord-023095-4dannjjm 6105 56 and and CC cord-023095-4dannjjm 6105 57 outcome outcome NN cord-023095-4dannjjm 6105 58 ( ( -LRB- cord-023095-4dannjjm 6105 59 survival survival NN cord-023095-4dannjjm 6105 60 to to TO cord-023095-4dannjjm 6105 61 discharge discharge VB cord-023095-4dannjjm 6105 62 ) ) -RRB- cord-023095-4dannjjm 6105 63 in in IN cord-023095-4dannjjm 6105 64 clinically clinically RB cord-023095-4dannjjm 6105 65 ill ill JJ cord-023095-4dannjjm 6105 66 dogs dog NNS cord-023095-4dannjjm 6105 67 . . . cord-023095-4dannjjm 6106 1 Clinically clinically RB cord-023095-4dannjjm 6106 2 ill ill JJ cord-023095-4dannjjm 6106 3 client client NN cord-023095-4dannjjm 6106 4 - - HYPH cord-023095-4dannjjm 6106 5 owned own VBN cord-023095-4dannjjm 6106 6 dogs dog NNS cord-023095-4dannjjm 6106 7 , , , cord-023095-4dannjjm 6106 8 admitted admit VBN cord-023095-4dannjjm 6106 9 to to IN cord-023095-4dannjjm 6106 10 the the DT cord-023095-4dannjjm 6106 11 UW UW NNP cord-023095-4dannjjm 6106 12 Veterinary Veterinary NNP cord-023095-4dannjjm 6106 13 Medical Medical NNP cord-023095-4dannjjm 6106 14 Teaching Teaching NNP cord-023095-4dannjjm 6106 15 Hospital Hospital NNP cord-023095-4dannjjm 6106 16 that that WDT cord-023095-4dannjjm 6106 17 did do VBD cord-023095-4dannjjm 6106 18 not not RB cord-023095-4dannjjm 6106 19 receive receive VB cord-023095-4dannjjm 6106 20 blood blood NN cord-023095-4dannjjm 6106 21 transfusions transfusion NNS cord-023095-4dannjjm 6106 22 , , , cord-023095-4dannjjm 6106 23 TPN TPN NNP cord-023095-4dannjjm 6106 24 , , , cord-023095-4dannjjm 6106 25 vitamins vitamin NNS cord-023095-4dannjjm 6106 26 , , , cord-023095-4dannjjm 6106 27 or or CC cord-023095-4dannjjm 6106 28 antioxidants antioxidant NNS cord-023095-4dannjjm 6106 29 were be VBD cord-023095-4dannjjm 6106 30 eligible eligible JJ cord-023095-4dannjjm 6106 31 for for IN cord-023095-4dannjjm 6106 32 the the DT cord-023095-4dannjjm 6106 33 study study NN cord-023095-4dannjjm 6106 34 . . . cord-023095-4dannjjm 6107 1 Dogs dog NNS cord-023095-4dannjjm 6107 2 enrolled enrol VBD cord-023095-4dannjjm 6107 3 in in IN cord-023095-4dannjjm 6107 4 the the DT cord-023095-4dannjjm 6107 5 study study NN cord-023095-4dannjjm 6107 6 were be VBD cord-023095-4dannjjm 6107 7 randomized randomize VBN cord-023095-4dannjjm 6107 8 to to TO cord-023095-4dannjjm 6107 9 receive receive VB cord-023095-4dannjjm 6107 10 IV IV NNP cord-023095-4dannjjm 6107 11 infusions infusion NNS cord-023095-4dannjjm 6107 12 q. q. NNP cord-023095-4dannjjm 6107 13 6 6 CD cord-023095-4dannjjm 6107 14 h. h. NN cord-023095-4dannjjm 6107 15 of of IN cord-023095-4dannjjm 6107 16 either either CC cord-023095-4dannjjm 6107 17 NAC NAC NNP cord-023095-4dannjjm 6107 18 ( ( -LRB- cord-023095-4dannjjm 6107 19 1 1 CD cord-023095-4dannjjm 6107 20 Â â CD cord-023095-4dannjjm 6107 21 140 140 CD cord-023095-4dannjjm 6107 22 mg mg NN cord-023095-4dannjjm 6107 23 / / SYM cord-023095-4dannjjm 6107 24 kg kg NNP cord-023095-4dannjjm 6107 25 and and CC cord-023095-4dannjjm 6107 26 6 6 CD cord-023095-4dannjjm 6107 27 Â â CD cord-023095-4dannjjm 6107 28 70 70 CD cord-023095-4dannjjm 6107 29 mg mg NNP cord-023095-4dannjjm 6107 30 / / SYM cord-023095-4dannjjm 6107 31 kg kg NNP cord-023095-4dannjjm 6107 32 ) ) -RRB- cord-023095-4dannjjm 6107 33 or or CC cord-023095-4dannjjm 6107 34 equal equal JJ cord-023095-4dannjjm 6107 35 volumes volume NNS cord-023095-4dannjjm 6107 36 of of IN cord-023095-4dannjjm 6107 37 5 5 CD cord-023095-4dannjjm 6107 38 % % NN cord-023095-4dannjjm 6107 39 dextrose dextrose NN cord-023095-4dannjjm 6107 40 ( ( -LRB- cord-023095-4dannjjm 6107 41 placebo placebo NN cord-023095-4dannjjm 6107 42 ) ) -RRB- cord-023095-4dannjjm 6107 43 over over IN cord-023095-4dannjjm 6107 44 48 48 CD cord-023095-4dannjjm 6107 45 hours hour NNS cord-023095-4dannjjm 6107 46 . . . cord-023095-4dannjjm 6108 1 At at IN cord-023095-4dannjjm 6108 2 the the DT cord-023095-4dannjjm 6108 3 time time NN cord-023095-4dannjjm 6108 4 of of IN cord-023095-4dannjjm 6108 5 enrollment enrollment NN cord-023095-4dannjjm 6108 6 , , , cord-023095-4dannjjm 6108 7 and and CC cord-023095-4dannjjm 6108 8 2 2 CD cord-023095-4dannjjm 6108 9 hours hour NNS cord-023095-4dannjjm 6108 10 following follow VBG cord-023095-4dannjjm 6108 11 the the DT cord-023095-4dannjjm 6108 12 final final JJ cord-023095-4dannjjm 6108 13 48 48 CD cord-023095-4dannjjm 6108 14 hour hour NN cord-023095-4dannjjm 6108 15 infusion infusion NN cord-023095-4dannjjm 6108 16 , , , cord-023095-4dannjjm 6108 17 blood blood NN cord-023095-4dannjjm 6108 18 and and CC cord-023095-4dannjjm 6108 19 urine urine NN cord-023095-4dannjjm 6108 20 were be VBD cord-023095-4dannjjm 6108 21 collected collect VBN cord-023095-4dannjjm 6108 22 to to TO cord-023095-4dannjjm 6108 23 quantify quantify VB cord-023095-4dannjjm 6108 24 RBC RBC NNP cord-023095-4dannjjm 6108 25 GSH GSH NNP cord-023095-4dannjjm 6108 26 , , , cord-023095-4dannjjm 6108 27 CYS CYS NNP cord-023095-4dannjjm 6108 28 , , , cord-023095-4dannjjm 6108 29 vit vit NNP cord-023095-4dannjjm 6108 30 E E NNP cord-023095-4dannjjm 6108 31 , , , cord-023095-4dannjjm 6108 32 and and CC cord-023095-4dannjjm 6108 33 Se Se NNP cord-023095-4dannjjm 6108 34 concentrations concentration NNS cord-023095-4dannjjm 6108 35 ; ; : cord-023095-4dannjjm 6108 36 U U NNP cord-023095-4dannjjm 6108 37 I I NNP cord-023095-4dannjjm 6108 38 / / SYM cord-023095-4dannjjm 6108 39 C c NN cord-023095-4dannjjm 6108 40 ratios ratio NNS cord-023095-4dannjjm 6108 41 ; ; : cord-023095-4dannjjm 6108 42 and and CC cord-023095-4dannjjm 6108 43 calculate calculate VB cord-023095-4dannjjm 6108 44 SPI2 SPI2 NNP cord-023095-4dannjjm 6108 45 scores score NNS cord-023095-4dannjjm 6108 46 . . . cord-023095-4dannjjm 6109 1 RBC RBC NNP cord-023095-4dannjjm 6109 2 GSH GSH NNP cord-023095-4dannjjm 6109 3 and and CC cord-023095-4dannjjm 6109 4 CYS CYS NNP cord-023095-4dannjjm 6109 5 concentrations concentration NNS cord-023095-4dannjjm 6109 6 were be VBD cord-023095-4dannjjm 6109 7 quantified quantify VBN cord-023095-4dannjjm 6109 8 by by IN cord-023095-4dannjjm 6109 9 HPLC HPLC NNP cord-023095-4dannjjm 6109 10 . . . cord-023095-4dannjjm 6110 1 Commercially commercially RB cord-023095-4dannjjm 6110 2 available available JJ cord-023095-4dannjjm 6110 3 HPLC HPLC NNP cord-023095-4dannjjm 6110 4 , , , cord-023095-4dannjjm 6110 5 atomic atomic JJ cord-023095-4dannjjm 6110 6 absorption absorption NN cord-023095-4dannjjm 6110 7 spectroscopy spectroscopy NN cord-023095-4dannjjm 6110 8 , , , cord-023095-4dannjjm 6110 9 and and CC cord-023095-4dannjjm 6110 10 EIA EIA NNP cord-023095-4dannjjm 6110 11 were be VBD cord-023095-4dannjjm 6110 12 used use VBN cord-023095-4dannjjm 6110 13 to to TO cord-023095-4dannjjm 6110 14 quantify quantify VB cord-023095-4dannjjm 6110 15 vit vit NNP cord-023095-4dannjjm 6110 16 E e NN cord-023095-4dannjjm 6110 17 , , , cord-023095-4dannjjm 6110 18 Se Se NNP cord-023095-4dannjjm 6110 19 , , , cord-023095-4dannjjm 6110 20 and and CC cord-023095-4dannjjm 6110 21 U U NNP cord-023095-4dannjjm 6110 22 I I NNP cord-023095-4dannjjm 6110 23 / / SYM cord-023095-4dannjjm 6110 24 C c NN cord-023095-4dannjjm 6110 25 ratios ratio NNS cord-023095-4dannjjm 6110 26 , , , cord-023095-4dannjjm 6110 27 respectively respectively RB cord-023095-4dannjjm 6110 28 . . . cord-023095-4dannjjm 6111 1 Nonparametric nonparametric JJ cord-023095-4dannjjm 6111 2 statistical statistical JJ cord-023095-4dannjjm 6111 3 analyses analysis NNS cord-023095-4dannjjm 6111 4 were be VBD cord-023095-4dannjjm 6111 5 used use VBN cord-023095-4dannjjm 6111 6 , , , cord-023095-4dannjjm 6111 7 with with IN cord-023095-4dannjjm 6111 8 results result NNS cord-023095-4dannjjm 6111 9 reported report VBN cord-023095-4dannjjm 6111 10 as as IN cord-023095-4dannjjm 6111 11 medians median NNS cord-023095-4dannjjm 6111 12 and and CC cord-023095-4dannjjm 6111 13 P p NN cord-023095-4dannjjm 6111 14 o o NN cord-023095-4dannjjm 6111 15 0.05 0.05 CD cord-023095-4dannjjm 6111 16 considered consider VBN cord-023095-4dannjjm 6111 17 significant significant JJ cord-023095-4dannjjm 6111 18 . . . cord-023095-4dannjjm 6112 1 Sixty sixty CD cord-023095-4dannjjm 6112 2 - - HYPH cord-023095-4dannjjm 6112 3 one one CD cord-023095-4dannjjm 6112 4 ill ill JJ cord-023095-4dannjjm 6112 5 dogs dog NNS cord-023095-4dannjjm 6112 6 were be VBD cord-023095-4dannjjm 6112 7 randomized randomize VBN cord-023095-4dannjjm 6112 8 to to IN cord-023095-4dannjjm 6112 9 either either CC cord-023095-4dannjjm 6112 10 NAC NAC NNP cord-023095-4dannjjm 6112 11 ( ( -LRB- cord-023095-4dannjjm 6112 12 n n NN cord-023095-4dannjjm 6112 13 5 5 CD cord-023095-4dannjjm 6112 14 30 30 CD cord-023095-4dannjjm 6112 15 ) ) -RRB- cord-023095-4dannjjm 6112 16 or or CC cord-023095-4dannjjm 6112 17 placebo placebo NN cord-023095-4dannjjm 6112 18 ( ( -LRB- cord-023095-4dannjjm 6112 19 n n NNP cord-023095-4dannjjm 6112 20 5 5 CD cord-023095-4dannjjm 6112 21 31 31 CD cord-023095-4dannjjm 6112 22 ) ) -RRB- cord-023095-4dannjjm 6112 23 . . . cord-023095-4dannjjm 6113 1 Overall overall RB cord-023095-4dannjjm 6113 2 this this DT cord-023095-4dannjjm 6113 3 group group NN cord-023095-4dannjjm 6113 4 of of IN cord-023095-4dannjjm 6113 5 ill ill JJ cord-023095-4dannjjm 6113 6 dogs dog NNS cord-023095-4dannjjm 6113 7 had have VBD cord-023095-4dannjjm 6113 8 significantly significantly RB cord-023095-4dannjjm 6113 9 decreased decrease VBN cord-023095-4dannjjm 6113 10 RBC RBC NNP cord-023095-4dannjjm 6113 11 GSH GSH NNP cord-023095-4dannjjm 6113 12 ( ( -LRB- cord-023095-4dannjjm 6113 13 1.50 1.50 CD cord-023095-4dannjjm 6113 14 vs. vs. NN cord-023095-4dannjjm 6113 15 1.91 1.91 CD cord-023095-4dannjjm 6113 16 mM mm NN cord-023095-4dannjjm 6113 17 ; ; : cord-023095-4dannjjm 6113 18 P p NN cord-023095-4dannjjm 6113 19 5 5 CD cord-023095-4dannjjm 6113 20 0.0013 0.0013 CD cord-023095-4dannjjm 6113 21 ) ) -RRB- cord-023095-4dannjjm 6113 22 , , , cord-023095-4dannjjm 6113 23 vit vit NNP cord-023095-4dannjjm 6113 24 E E NNP cord-023095-4dannjjm 6113 25 ( ( -LRB- cord-023095-4dannjjm 6113 26 27 27 CD cord-023095-4dannjjm 6113 27 vs. vs. NN cord-023095-4dannjjm 6113 28 56 56 CD cord-023095-4dannjjm 6113 29 mg mg NNP cord-023095-4dannjjm 6113 30 / / SYM cord-023095-4dannjjm 6113 31 mL ml NN cord-023095-4dannjjm 6113 32 ; ; : cord-023095-4dannjjm 6113 33 P p NN cord-023095-4dannjjm 6113 34 5 5 CD cord-023095-4dannjjm 6113 35 0.0002 0.0002 CD cord-023095-4dannjjm 6113 36 ) ) -RRB- cord-023095-4dannjjm 6113 37 , , , cord-023095-4dannjjm 6113 38 and and CC cord-023095-4dannjjm 6113 39 Se Se NNP cord-023095-4dannjjm 6113 40 ( ( -LRB- cord-023095-4dannjjm 6113 41 0.37 0.37 CD cord-023095-4dannjjm 6113 42 vs. vs. IN cord-023095-4dannjjm 6113 43 0.55 0.55 CD cord-023095-4dannjjm 6113 44 mg mg NNP cord-023095-4dannjjm 6113 45 / / SYM cord-023095-4dannjjm 6113 46 mL ml NN cord-023095-4dannjjm 6113 47 ; ; : cord-023095-4dannjjm 6113 48 P p NN cord-023095-4dannjjm 6113 49 5 5 CD cord-023095-4dannjjm 6113 50 0.0308 0.0308 CD cord-023095-4dannjjm 6113 51 ) ) -RRB- cord-023095-4dannjjm 6113 52 levels level NNS cord-023095-4dannjjm 6113 53 and and CC cord-023095-4dannjjm 6113 54 elevated elevated JJ cord-023095-4dannjjm 6113 55 U u NN cord-023095-4dannjjm 6113 56 I I NNP cord-023095-4dannjjm 6113 57 / / SYM cord-023095-4dannjjm 6113 58 C c NN cord-023095-4dannjjm 6113 59 ratios ratio NNS cord-023095-4dannjjm 6113 60 ( ( -LRB- cord-023095-4dannjjm 6113 61 969 969 CD cord-023095-4dannjjm 6113 62 vs. vs. NN cord-023095-4dannjjm 6113 63 398 398 CD cord-023095-4dannjjm 6113 64 pg pg NNP cord-023095-4dannjjm 6113 65 / / SYM cord-023095-4dannjjm 6113 66 mg mg NN cord-023095-4dannjjm 6113 67 ; ; : cord-023095-4dannjjm 6113 68 P p NN cord-023095-4dannjjm 6113 69 5 5 CD cord-023095-4dannjjm 6113 70 0.0005 0.0005 CD cord-023095-4dannjjm 6113 71 ) ) -RRB- cord-023095-4dannjjm 6113 72 in in IN cord-023095-4dannjjm 6113 73 comparison comparison NN cord-023095-4dannjjm 6113 74 to to IN cord-023095-4dannjjm 6113 75 healthy healthy JJ cord-023095-4dannjjm 6113 76 control control NN cord-023095-4dannjjm 6113 77 dogs dog NNS cord-023095-4dannjjm 6113 78 . . . cord-023095-4dannjjm 6114 1 Dogs dog NNS cord-023095-4dannjjm 6114 2 in in IN cord-023095-4dannjjm 6114 3 the the DT cord-023095-4dannjjm 6114 4 placebo placebo NN cord-023095-4dannjjm 6114 5 group group NN cord-023095-4dannjjm 6114 6 showed show VBD cord-023095-4dannjjm 6114 7 a a DT cord-023095-4dannjjm 6114 8 significant significant JJ cord-023095-4dannjjm 6114 9 further further JJ cord-023095-4dannjjm 6114 10 decrease decrease NN cord-023095-4dannjjm 6114 11 in in IN cord-023095-4dannjjm 6114 12 RBC RBC NNP cord-023095-4dannjjm 6114 13 GSH GSH NNP cord-023095-4dannjjm 6114 14 over over IN cord-023095-4dannjjm 6114 15 the the DT cord-023095-4dannjjm 6114 16 next next JJ cord-023095-4dannjjm 6114 17 48 48 CD cord-023095-4dannjjm 6114 18 hours hour NNS cord-023095-4dannjjm 6114 19 ( ( -LRB- cord-023095-4dannjjm 6114 20 1.48 1.48 CD cord-023095-4dannjjm 6114 21 to to IN cord-023095-4dannjjm 6114 22 1.42 1.42 CD cord-023095-4dannjjm 6114 23 ; ; : cord-023095-4dannjjm 6114 24 P p NN cord-023095-4dannjjm 6114 25 5 5 CD cord-023095-4dannjjm 6114 26 0.035 0.035 CD cord-023095-4dannjjm 6114 27 ) ) -RRB- cord-023095-4dannjjm 6114 28 . . . cord-023095-4dannjjm 6115 1 NAC NAC NNP cord-023095-4dannjjm 6115 2 supplementation supplementation NN cord-023095-4dannjjm 6115 3 significantly significantly RB cord-023095-4dannjjm 6115 4 increased increase VBD cord-023095-4dannjjm 6115 5 plasma plasma NN cord-023095-4dannjjm 6115 6 CYS CYS NNP cord-023095-4dannjjm 6115 7 levels level NNS cord-023095-4dannjjm 6115 8 ( ( -LRB- cord-023095-4dannjjm 6115 9 9.1 9.1 CD cord-023095-4dannjjm 6115 10 to to IN cord-023095-4dannjjm 6115 11 15.1 15.1 CD cord-023095-4dannjjm 6115 12 mM mm CD cord-023095-4dannjjm 6115 13 ; ; : cord-023095-4dannjjm 6115 14 P p NN cord-023095-4dannjjm 6115 15 o o NN cord-023095-4dannjjm 6115 16 0.0001 0.0001 CD cord-023095-4dannjjm 6115 17 ) ) -RRB- cord-023095-4dannjjm 6115 18 , , , cord-023095-4dannjjm 6115 19 and and CC cord-023095-4dannjjm 6115 20 prevented prevent VBD cord-023095-4dannjjm 6115 21 a a DT cord-023095-4dannjjm 6115 22 further further JJ cord-023095-4dannjjm 6115 23 decline decline NN cord-023095-4dannjjm 6115 24 in in IN cord-023095-4dannjjm 6115 25 RBC RBC NNP cord-023095-4dannjjm 6115 26 GSH GSH NNP cord-023095-4dannjjm 6115 27 ( ( -LRB- cord-023095-4dannjjm 6115 28 1.55 1.55 CD cord-023095-4dannjjm 6115 29 to to TO cord-023095-4dannjjm 6115 30 1.58 1.58 CD cord-023095-4dannjjm 6115 31 mM mm CD cord-023095-4dannjjm 6115 32 ; ; : cord-023095-4dannjjm 6115 33 P p NN cord-023095-4dannjjm 6115 34 5 5 CD cord-023095-4dannjjm 6115 35 0.174 0.174 CD cord-023095-4dannjjm 6115 36 ) ) -RRB- cord-023095-4dannjjm 6115 37 . . . cord-023095-4dannjjm 6116 1 However however RB cord-023095-4dannjjm 6116 2 , , , cord-023095-4dannjjm 6116 3 serum serum NN cord-023095-4dannjjm 6116 4 vit vit NN cord-023095-4dannjjm 6116 5 E e NN cord-023095-4dannjjm 6116 6 ( ( -LRB- cord-023095-4dannjjm 6116 7 30 30 CD cord-023095-4dannjjm 6116 8 vs. vs. IN cord-023095-4dannjjm 6116 9 28 28 CD cord-023095-4dannjjm 6116 10 mg mg NNP cord-023095-4dannjjm 6116 11 / / SYM cord-023095-4dannjjm 6116 12 mL mL NNP cord-023095-4dannjjm 6116 13 ) ) -RRB- cord-023095-4dannjjm 6116 14 , , , cord-023095-4dannjjm 6116 15 Se Se NNP cord-023095-4dannjjm 6116 16 ( ( -LRB- cord-023095-4dannjjm 6116 17 0.40 0.40 CD cord-023095-4dannjjm 6116 18 vs. vs. CC cord-023095-4dannjjm 6116 19 0.35 0.35 CD cord-023095-4dannjjm 6116 20 mg/ mg/ NN cord-023095-4dannjjm 6116 21 mL mL NNP cord-023095-4dannjjm 6116 22 ) ) -RRB- cord-023095-4dannjjm 6116 23 , , , cord-023095-4dannjjm 6116 24 U U NNP cord-023095-4dannjjm 6116 25 I I NNP cord-023095-4dannjjm 6116 26 / / SYM cord-023095-4dannjjm 6116 27 C c NN cord-023095-4dannjjm 6116 28 ratios ratio NNS cord-023095-4dannjjm 6116 29 ( ( -LRB- cord-023095-4dannjjm 6116 30 946 946 CD cord-023095-4dannjjm 6116 31 vs. vs. NN cord-023095-4dannjjm 6116 32 806 806 CD cord-023095-4dannjjm 6116 33 pg pg NNP cord-023095-4dannjjm 6116 34 / / SYM cord-023095-4dannjjm 6116 35 mg mg NNP cord-023095-4dannjjm 6116 36 ) ) -RRB- cord-023095-4dannjjm 6116 37 , , , cord-023095-4dannjjm 6116 38 SPI2 SPI2 NNP cord-023095-4dannjjm 6116 39 scores score NNS cord-023095-4dannjjm 6116 40 ( ( -LRB- cord-023095-4dannjjm 6116 41 0.74 0.74 CD cord-023095-4dannjjm 6116 42 vs. vs. CC cord-023095-4dannjjm 6116 43 0.75 0.75 CD cord-023095-4dannjjm 6116 44 ) ) -RRB- cord-023095-4dannjjm 6116 45 , , , cord-023095-4dannjjm 6116 46 and and CC cord-023095-4dannjjm 6116 47 outcome outcome NN cord-023095-4dannjjm 6116 48 ( ( -LRB- cord-023095-4dannjjm 6116 49 81 81 CD cord-023095-4dannjjm 6116 50 % % NN cord-023095-4dannjjm 6116 51 vs. vs. CC cord-023095-4dannjjm 6116 52 76 76 CD cord-023095-4dannjjm 6116 53 % % NN cord-023095-4dannjjm 6116 54 ) ) -RRB- cord-023095-4dannjjm 6116 55 were be VBD cord-023095-4dannjjm 6116 56 not not RB cord-023095-4dannjjm 6116 57 significantly significantly RB cord-023095-4dannjjm 6116 58 different different JJ cord-023095-4dannjjm 6116 59 between between IN cord-023095-4dannjjm 6116 60 the the DT cord-023095-4dannjjm 6116 61 NAC NAC NNP cord-023095-4dannjjm 6116 62 and and CC cord-023095-4dannjjm 6116 63 placebo placebo NN cord-023095-4dannjjm 6116 64 groups group NNS cord-023095-4dannjjm 6116 65 after after IN cord-023095-4dannjjm 6116 66 treatment treatment NN cord-023095-4dannjjm 6116 67 . . . cord-023095-4dannjjm 6117 1 The the DT cord-023095-4dannjjm 6117 2 results result NNS cord-023095-4dannjjm 6117 3 of of IN cord-023095-4dannjjm 6117 4 this this DT cord-023095-4dannjjm 6117 5 study study NN cord-023095-4dannjjm 6117 6 further far RBR cord-023095-4dannjjm 6117 7 support support NN cord-023095-4dannjjm 6117 8 that that WDT cord-023095-4dannjjm 6117 9 clinically clinically RB cord-023095-4dannjjm 6117 10 ill ill JJ cord-023095-4dannjjm 6117 11 dogs dog NNS cord-023095-4dannjjm 6117 12 experience experience NN cord-023095-4dannjjm 6117 13 oxidative oxidative JJ cord-023095-4dannjjm 6117 14 stress stress NN cord-023095-4dannjjm 6117 15 , , , cord-023095-4dannjjm 6117 16 and and CC cord-023095-4dannjjm 6117 17 suggest suggest VBP cord-023095-4dannjjm 6117 18 that that IN cord-023095-4dannjjm 6117 19 antioxidant antioxidant JJ cord-023095-4dannjjm 6117 20 supplementation supplementation NN cord-023095-4dannjjm 6117 21 with with IN cord-023095-4dannjjm 6117 22 NAC NAC NNP cord-023095-4dannjjm 6117 23 within within IN cord-023095-4dannjjm 6117 24 the the DT cord-023095-4dannjjm 6117 25 first first JJ cord-023095-4dannjjm 6117 26 48 48 CD cord-023095-4dannjjm 6117 27 hours hour NNS cord-023095-4dannjjm 6117 28 of of IN cord-023095-4dannjjm 6117 29 hospitalization hospitalization NN cord-023095-4dannjjm 6117 30 prevents prevent VBZ cord-023095-4dannjjm 6117 31 further far RBR cord-023095-4dannjjm 6117 32 RBC RBC NNP cord-023095-4dannjjm 6117 33 GSH GSH NNP cord-023095-4dannjjm 6117 34 depletion depletion NN cord-023095-4dannjjm 6117 35 . . . cord-023095-4dannjjm 6118 1 Further further JJ cord-023095-4dannjjm 6118 2 studies study NNS cord-023095-4dannjjm 6118 3 are be VBP cord-023095-4dannjjm 6118 4 necessary necessary JJ cord-023095-4dannjjm 6118 5 to to TO cord-023095-4dannjjm 6118 6 investigate investigate VB cord-023095-4dannjjm 6118 7 whether whether IN cord-023095-4dannjjm 6118 8 longer long JJR cord-023095-4dannjjm 6118 9 duration duration NN cord-023095-4dannjjm 6118 10 or or CC cord-023095-4dannjjm 6118 11 combined combine VBN cord-023095-4dannjjm 6118 12 antioxidant antioxidant NN cord-023095-4dannjjm 6118 13 supplementation supplementation NN cord-023095-4dannjjm 6118 14 normalizes normalize VBZ cord-023095-4dannjjm 6118 15 the the DT cord-023095-4dannjjm 6118 16 redox redox JJ cord-023095-4dannjjm 6118 17 state state NN cord-023095-4dannjjm 6118 18 and and CC cord-023095-4dannjjm 6118 19 impacts impact NNS cord-023095-4dannjjm 6118 20 long long JJ cord-023095-4dannjjm 6118 21 - - HYPH cord-023095-4dannjjm 6118 22 term term NN cord-023095-4dannjjm 6118 23 outcome outcome NN cord-023095-4dannjjm 6118 24 . . . cord-023095-4dannjjm 6119 1 Diabetes diabetes NN cord-023095-4dannjjm 6119 2 Mellitus mellitus NN cord-023095-4dannjjm 6119 3 in in IN cord-023095-4dannjjm 6119 4 cats cat NNS cord-023095-4dannjjm 6119 5 is be VBZ cord-023095-4dannjjm 6119 6 very very RB cord-023095-4dannjjm 6119 7 similar similar JJ cord-023095-4dannjjm 6119 8 to to IN cord-023095-4dannjjm 6119 9 Type Type NNP cord-023095-4dannjjm 6119 10 II II NNP cord-023095-4dannjjm 6119 11 Diabetes diabetes NN cord-023095-4dannjjm 6119 12 in in IN cord-023095-4dannjjm 6119 13 Humans Humans NNPS cord-023095-4dannjjm 6119 14 , , , cord-023095-4dannjjm 6119 15 preceded precede VBN cord-023095-4dannjjm 6119 16 by by IN cord-023095-4dannjjm 6119 17 a a DT cord-023095-4dannjjm 6119 18 period period NN cord-023095-4dannjjm 6119 19 of of IN cord-023095-4dannjjm 6119 20 insulin insulin NN cord-023095-4dannjjm 6119 21 resistance resistance NN cord-023095-4dannjjm 6119 22 . . . cord-023095-4dannjjm 6120 1 Evaluating evaluate VBG cord-023095-4dannjjm 6120 2 insulin insulin NN cord-023095-4dannjjm 6120 3 resistance resistance NN cord-023095-4dannjjm 6120 4 in in IN cord-023095-4dannjjm 6120 5 a a DT cord-023095-4dannjjm 6120 6 cat cat NN cord-023095-4dannjjm 6120 7 is be VBZ cord-023095-4dannjjm 6120 8 a a DT cord-023095-4dannjjm 6120 9 time time NN cord-023095-4dannjjm 6120 10 consuming consume VBG cord-023095-4dannjjm 6120 11 , , , cord-023095-4dannjjm 6120 12 expensive expensive JJ cord-023095-4dannjjm 6120 13 , , , cord-023095-4dannjjm 6120 14 and and CC cord-023095-4dannjjm 6120 15 difficult difficult JJ cord-023095-4dannjjm 6120 16 procedure procedure NN cord-023095-4dannjjm 6120 17 . . . cord-023095-4dannjjm 6121 1 There there EX cord-023095-4dannjjm 6121 2 is be VBZ cord-023095-4dannjjm 6121 3 a a DT cord-023095-4dannjjm 6121 4 need need NN cord-023095-4dannjjm 6121 5 for for IN cord-023095-4dannjjm 6121 6 a a DT cord-023095-4dannjjm 6121 7 simple simple JJ cord-023095-4dannjjm 6121 8 biomarker biomarker NN cord-023095-4dannjjm 6121 9 based base VBN cord-023095-4dannjjm 6121 10 test test NN cord-023095-4dannjjm 6121 11 predictive predictive NN cord-023095-4dannjjm 6121 12 of of IN cord-023095-4dannjjm 6121 13 insulin insulin NN cord-023095-4dannjjm 6121 14 resistance resistance NN cord-023095-4dannjjm 6121 15 . . . cord-023095-4dannjjm 6122 1 There there EX cord-023095-4dannjjm 6122 2 is be VBZ cord-023095-4dannjjm 6122 3 a a DT cord-023095-4dannjjm 6122 4 biomarker biomarker NN cord-023095-4dannjjm 6122 5 based base VBN cord-023095-4dannjjm 6122 6 assay assay NN cord-023095-4dannjjm 6122 7 predicative predicative JJ cord-023095-4dannjjm 6122 8 of of IN cord-023095-4dannjjm 6122 9 insulin insulin NN cord-023095-4dannjjm 6122 10 resistance resistance NN cord-023095-4dannjjm 6122 11 in in IN cord-023095-4dannjjm 6122 12 humans human NNS cord-023095-4dannjjm 6122 13 . . . cord-023095-4dannjjm 6123 1 The the DT cord-023095-4dannjjm 6123 2 purpose purpose NN cord-023095-4dannjjm 6123 3 of of IN cord-023095-4dannjjm 6123 4 this this DT cord-023095-4dannjjm 6123 5 study study NN cord-023095-4dannjjm 6123 6 was be VBD cord-023095-4dannjjm 6123 7 to to TO cord-023095-4dannjjm 6123 8 evaluate evaluate VB cord-023095-4dannjjm 6123 9 the the DT cord-023095-4dannjjm 6123 10 utility utility NN cord-023095-4dannjjm 6123 11 of of IN cord-023095-4dannjjm 6123 12 this this DT cord-023095-4dannjjm 6123 13 assay assay NN cord-023095-4dannjjm 6123 14 in in IN cord-023095-4dannjjm 6123 15 overweight overweight JJ cord-023095-4dannjjm 6123 16 cats cat NNS cord-023095-4dannjjm 6123 17 and and CC cord-023095-4dannjjm 6123 18 show show VBP cord-023095-4dannjjm 6123 19 improvement improvement NN cord-023095-4dannjjm 6123 20 in in IN cord-023095-4dannjjm 6123 21 insulin insulin NN cord-023095-4dannjjm 6123 22 sensitivity sensitivity NN cord-023095-4dannjjm 6123 23 following follow VBG cord-023095-4dannjjm 6123 24 weight weight NN cord-023095-4dannjjm 6123 25 loss loss NN cord-023095-4dannjjm 6123 26 and and CC cord-023095-4dannjjm 6123 27 weight weight NN cord-023095-4dannjjm 6123 28 maintenance maintenance NN cord-023095-4dannjjm 6123 29 . . . cord-023095-4dannjjm 6124 1 The the DT cord-023095-4dannjjm 6124 2 insulin insulin NN cord-023095-4dannjjm 6124 3 resistance resistance NN cord-023095-4dannjjm 6124 4 assay assay NN cord-023095-4dannjjm 6124 5 is be VBZ cord-023095-4dannjjm 6124 6 based base VBN cord-023095-4dannjjm 6124 7 on on IN cord-023095-4dannjjm 6124 8 the the DT cord-023095-4dannjjm 6124 9 quantitative quantitative JJ cord-023095-4dannjjm 6124 10 analysis analysis NN cord-023095-4dannjjm 6124 11 of of IN cord-023095-4dannjjm 6124 12 5 5 CD cord-023095-4dannjjm 6124 13 metabolites metabolite NNS cord-023095-4dannjjm 6124 14 ( ( -LRB- cord-023095-4dannjjm 6124 15 2-hydroxybuterate 2-hydroxybuterate CD cord-023095-4dannjjm 6124 16 , , , cord-023095-4dannjjm 6124 17 creatine creatine NN cord-023095-4dannjjm 6124 18 , , , cord-023095-4dannjjm 6124 19 palmitate palmitate NN cord-023095-4dannjjm 6124 20 , , , cord-023095-4dannjjm 6124 21 decanoylcarnitine decanoylcarnitine NNP cord-023095-4dannjjm 6124 22 , , , cord-023095-4dannjjm 6124 23 and and CC cord-023095-4dannjjm 6124 24 oleoyl oleoyl NNP cord-023095-4dannjjm 6124 25 - - HYPH cord-023095-4dannjjm 6124 26 LPC LPC NNP cord-023095-4dannjjm 6124 27 ) ) -RRB- cord-023095-4dannjjm 6124 28 . . . cord-023095-4dannjjm 6125 1 A a DT cord-023095-4dannjjm 6125 2 proprietary proprietary JJ cord-023095-4dannjjm 6125 3 algorithm algorithm NN cord-023095-4dannjjm 6125 4 ( ( -LRB- cord-023095-4dannjjm 6125 5 Metabolon Metabolon NNP cord-023095-4dannjjm 6125 6 , , , cord-023095-4dannjjm 6125 7 Inc Inc NNP cord-023095-4dannjjm 6125 8 , , , cord-023095-4dannjjm 6125 9 Durham Durham NNP cord-023095-4dannjjm 6125 10 NC NC NNP cord-023095-4dannjjm 6125 11 ) ) -RRB- cord-023095-4dannjjm 6125 12 was be VBD cord-023095-4dannjjm 6125 13 used use VBN cord-023095-4dannjjm 6125 14 to to TO cord-023095-4dannjjm 6125 15 generate generate VB cord-023095-4dannjjm 6125 16 a a DT cord-023095-4dannjjm 6125 17 predictive predictive JJ cord-023095-4dannjjm 6125 18 RD RD NNP cord-023095-4dannjjm 6125 19 ( ( -LRB- cord-023095-4dannjjm 6125 20 Rate rate NN cord-023095-4dannjjm 6125 21 of of IN cord-023095-4dannjjm 6125 22 Disposal Disposal NNP cord-023095-4dannjjm 6125 23 ) ) -RRB- cord-023095-4dannjjm 6125 24 value value NN cord-023095-4dannjjm 6125 25 ( ( -LRB- cord-023095-4dannjjm 6125 26 normal normal JJ cord-023095-4dannjjm 6125 27 range range NN cord-023095-4dannjjm 6125 28 in in IN cord-023095-4dannjjm 6125 29 cats cat NNS cord-023095-4dannjjm 6125 30 6.5 6.5 CD cord-023095-4dannjjm 6125 31 - - HYPH cord-023095-4dannjjm 6125 32 10.5 10.5 CD cord-023095-4dannjjm 6125 33 ) ) -RRB- cord-023095-4dannjjm 6125 34 . . . cord-023095-4dannjjm 6126 1 Individuals individual NNS cord-023095-4dannjjm 6126 2 with with IN cord-023095-4dannjjm 6126 3 an an DT cord-023095-4dannjjm 6126 4 RD RD NNP cord-023095-4dannjjm 6126 5 value value NN cord-023095-4dannjjm 6126 6 less less JJR cord-023095-4dannjjm 6126 7 than than IN cord-023095-4dannjjm 6126 8 6 6 CD cord-023095-4dannjjm 6126 9 will will MD cord-023095-4dannjjm 6126 10 have have VB cord-023095-4dannjjm 6126 11 a a DT cord-023095-4dannjjm 6126 12 greater great JJR cord-023095-4dannjjm 6126 13 than than IN cord-023095-4dannjjm 6126 14 50 50 CD cord-023095-4dannjjm 6126 15 % % NN cord-023095-4dannjjm 6126 16 chance chance NN cord-023095-4dannjjm 6126 17 of of IN cord-023095-4dannjjm 6126 18 being be VBG cord-023095-4dannjjm 6126 19 insulin insulin NN cord-023095-4dannjjm 6126 20 resistant resistant JJ cord-023095-4dannjjm 6126 21 and and CC cord-023095-4dannjjm 6126 22 an an DT cord-023095-4dannjjm 6126 23 RD RD NNP cord-023095-4dannjjm 6126 24 value value NN cord-023095-4dannjjm 6126 25 less less JJR cord-023095-4dannjjm 6126 26 than than IN cord-023095-4dannjjm 6126 27 3 3 CD cord-023095-4dannjjm 6126 28 will will MD cord-023095-4dannjjm 6126 29 have have VB cord-023095-4dannjjm 6126 30 a a DT cord-023095-4dannjjm 6126 31 greater great JJR cord-023095-4dannjjm 6126 32 than than IN cord-023095-4dannjjm 6126 33 90 90 CD cord-023095-4dannjjm 6126 34 % % NN cord-023095-4dannjjm 6126 35 chance chance NN cord-023095-4dannjjm 6126 36 of of IN cord-023095-4dannjjm 6126 37 being be VBG cord-023095-4dannjjm 6126 38 insulin insulin NN cord-023095-4dannjjm 6126 39 resistant resistant JJ cord-023095-4dannjjm 6126 40 . . . cord-023095-4dannjjm 6127 1 Initial initial JJ cord-023095-4dannjjm 6127 2 studies study NNS cord-023095-4dannjjm 6127 3 demonstrated demonstrate VBD cord-023095-4dannjjm 6127 4 that that IN cord-023095-4dannjjm 6127 5 the the DT cord-023095-4dannjjm 6127 6 RD RD NNP cord-023095-4dannjjm 6127 7 values value NNS cord-023095-4dannjjm 6127 8 indicating indicate VBG cord-023095-4dannjjm 6127 9 insulin insulin NN cord-023095-4dannjjm 6127 10 resistance resistance NN cord-023095-4dannjjm 6127 11 in in IN cord-023095-4dannjjm 6127 12 cats cat NNS cord-023095-4dannjjm 6127 13 correlated correlate VBD cord-023095-4dannjjm 6127 14 with with IN cord-023095-4dannjjm 6127 15 age age NN cord-023095-4dannjjm 6127 16 , , , cord-023095-4dannjjm 6127 17 obesity obesity NN cord-023095-4dannjjm 6127 18 and and CC cord-023095-4dannjjm 6127 19 severity severity NN cord-023095-4dannjjm 6127 20 of of IN cord-023095-4dannjjm 6127 21 diabetes diabetes NN cord-023095-4dannjjm 6127 22 as as IN cord-023095-4dannjjm 6127 23 determined determine VBN cord-023095-4dannjjm 6127 24 by by IN cord-023095-4dannjjm 6127 25 histopathology histopathology NN cord-023095-4dannjjm 6127 26 and and CC cord-023095-4dannjjm 6127 27 blood blood NN cord-023095-4dannjjm 6127 28 glucose glucose NN cord-023095-4dannjjm 6127 29 levels level NNS cord-023095-4dannjjm 6127 30 . . . cord-023095-4dannjjm 6128 1 In in IN cord-023095-4dannjjm 6128 2 a a DT cord-023095-4dannjjm 6128 3 feeding feeding NN cord-023095-4dannjjm 6128 4 study study NN cord-023095-4dannjjm 6128 5 of of IN cord-023095-4dannjjm 6128 6 40 40 CD cord-023095-4dannjjm 6128 7 cats cat NNS cord-023095-4dannjjm 6128 8 ( ( -LRB- cord-023095-4dannjjm 6128 9 4 4 CD cord-023095-4dannjjm 6128 10 39 39 CD cord-023095-4dannjjm 6128 11 % % NN cord-023095-4dannjjm 6128 12 vs. vs. CC cord-023095-4dannjjm 6128 13 o o NN cord-023095-4dannjjm 6128 14 25 25 CD cord-023095-4dannjjm 6128 15 % % NN cord-023095-4dannjjm 6128 16 body body NN cord-023095-4dannjjm 6128 17 fat fat NN cord-023095-4dannjjm 6128 18 ) ) -RRB- cord-023095-4dannjjm 6129 1 RD RD NNP cord-023095-4dannjjm 6129 2 values value NNS cord-023095-4dannjjm 6129 3 improved improve VBD cord-023095-4dannjjm 6129 4 from from IN cord-023095-4dannjjm 6129 5 6.19 6.19 CD cord-023095-4dannjjm 6129 6 AE AE NNP cord-023095-4dannjjm 6129 7 1.23 1.23 CD cord-023095-4dannjjm 6129 8 to to IN cord-023095-4dannjjm 6129 9 6.8411.38 6.8411.38 CD cord-023095-4dannjjm 6130 1 ( ( -LRB- cord-023095-4dannjjm 6130 2 p p NN cord-023095-4dannjjm 6130 3 5 5 CD cord-023095-4dannjjm 6130 4 0.029 0.029 CD cord-023095-4dannjjm 6130 5 ) ) -RRB- cord-023095-4dannjjm 6130 6 . . . cord-023095-4dannjjm 6131 1 During during IN cord-023095-4dannjjm 6131 2 weight weight NN cord-023095-4dannjjm 6131 3 maintenance maintenance NN cord-023095-4dannjjm 6131 4 , , , cord-023095-4dannjjm 6131 5 19 19 CD cord-023095-4dannjjm 6131 6 % % NN cord-023095-4dannjjm 6131 7 body body NN cord-023095-4dannjjm 6131 8 fat fat NN cord-023095-4dannjjm 6131 9 for for IN cord-023095-4dannjjm 6131 10 4 4 CD cord-023095-4dannjjm 6131 11 months month NNS cord-023095-4dannjjm 6131 12 , , , cord-023095-4dannjjm 6131 13 further further JJ cord-023095-4dannjjm 6131 14 improvement improvement NN cord-023095-4dannjjm 6131 15 was be VBD cord-023095-4dannjjm 6131 16 observed observe VBN cord-023095-4dannjjm 6131 17 ( ( -LRB- cord-023095-4dannjjm 6131 18 RD RD NNP cord-023095-4dannjjm 6131 19 , , , cord-023095-4dannjjm 6131 20 8.30 8.30 CD cord-023095-4dannjjm 6131 21 1 1 CD cord-023095-4dannjjm 6131 22 1.08 1.08 CD cord-023095-4dannjjm 6131 23 ( ( -LRB- cord-023095-4dannjjm 6131 24 p p NN cord-023095-4dannjjm 6131 25 5 5 CD cord-023095-4dannjjm 6131 26 9.2E-12 9.2e-12 CD cord-023095-4dannjjm 6131 27 ) ) -RRB- cord-023095-4dannjjm 6131 28 ) ) -RRB- cord-023095-4dannjjm 6131 29 . . . cord-023095-4dannjjm 6132 1 These these DT cord-023095-4dannjjm 6132 2 results result NNS cord-023095-4dannjjm 6132 3 demonstrate demonstrate VBP cord-023095-4dannjjm 6132 4 that that IN cord-023095-4dannjjm 6132 5 long long JJ cord-023095-4dannjjm 6132 6 term term NN cord-023095-4dannjjm 6132 7 weight weight NN cord-023095-4dannjjm 6132 8 maintenance maintenance NN cord-023095-4dannjjm 6132 9 following follow VBG cord-023095-4dannjjm 6132 10 weight weight NN cord-023095-4dannjjm 6132 11 loss loss NN cord-023095-4dannjjm 6132 12 is be VBZ cord-023095-4dannjjm 6132 13 critical critical JJ cord-023095-4dannjjm 6132 14 for for IN cord-023095-4dannjjm 6132 15 increasing increase VBG cord-023095-4dannjjm 6132 16 insulin insulin NN cord-023095-4dannjjm 6132 17 sensitivity sensitivity NN cord-023095-4dannjjm 6132 18 in in IN cord-023095-4dannjjm 6132 19 cats cat NNS cord-023095-4dannjjm 6132 20 . . . cord-023095-4dannjjm 6133 1 The the DT cord-023095-4dannjjm 6133 2 use use NN cord-023095-4dannjjm 6133 3 of of IN cord-023095-4dannjjm 6133 4 monoclonal monoclonal JJ cord-023095-4dannjjm 6133 5 antibodies antibody NNS cord-023095-4dannjjm 6133 6 and and CC cord-023095-4dannjjm 6133 7 antibody antibody NN cord-023095-4dannjjm 6133 8 fragments fragment NNS cord-023095-4dannjjm 6133 9 to to TO cord-023095-4dannjjm 6133 10 directly directly RB cord-023095-4dannjjm 6133 11 target target VB cord-023095-4dannjjm 6133 12 tumor tumor NN cord-023095-4dannjjm 6133 13 antigens antigen NNS cord-023095-4dannjjm 6133 14 and and CC cord-023095-4dannjjm 6133 15 neutralize neutralize VB cord-023095-4dannjjm 6133 16 their -PRON- PRP$ cord-023095-4dannjjm 6133 17 growth growth NN cord-023095-4dannjjm 6133 18 factors factor NNS cord-023095-4dannjjm 6133 19 has have VBZ cord-023095-4dannjjm 6133 20 shown show VBN cord-023095-4dannjjm 6133 21 promising promising JJ cord-023095-4dannjjm 6133 22 results result NNS cord-023095-4dannjjm 6133 23 in in IN cord-023095-4dannjjm 6133 24 human human JJ cord-023095-4dannjjm 6133 25 clinical clinical JJ cord-023095-4dannjjm 6133 26 trials trial NNS cord-023095-4dannjjm 6133 27 . . . cord-023095-4dannjjm 6134 1 However however RB cord-023095-4dannjjm 6134 2 , , , cord-023095-4dannjjm 6134 3 these these DT cord-023095-4dannjjm 6134 4 targeted target VBN cord-023095-4dannjjm 6134 5 approaches approach NNS cord-023095-4dannjjm 6134 6 have have VBP cord-023095-4dannjjm 6134 7 not not RB cord-023095-4dannjjm 6134 8 been be VBN cord-023095-4dannjjm 6134 9 possible possible JJ cord-023095-4dannjjm 6134 10 in in IN cord-023095-4dannjjm 6134 11 dogs dog NNS cord-023095-4dannjjm 6134 12 since since IN cord-023095-4dannjjm 6134 13 specific specific JJ cord-023095-4dannjjm 6134 14 tumor tumor NN cord-023095-4dannjjm 6134 15 antigens antigen NNS cord-023095-4dannjjm 6134 16 have have VBP cord-023095-4dannjjm 6134 17 not not RB cord-023095-4dannjjm 6134 18 been be VBN cord-023095-4dannjjm 6134 19 identified identify VBN cord-023095-4dannjjm 6134 20 , , , cord-023095-4dannjjm 6134 21 monoclonal monoclonal JJ cord-023095-4dannjjm 6134 22 antibodies antibody NNS cord-023095-4dannjjm 6134 23 of of IN cord-023095-4dannjjm 6134 24 canine canine JJ cord-023095-4dannjjm 6134 25 origin origin NN cord-023095-4dannjjm 6134 26 are be VBP cord-023095-4dannjjm 6134 27 not not RB cord-023095-4dannjjm 6134 28 available available JJ cord-023095-4dannjjm 6134 29 and and CC cord-023095-4dannjjm 6134 30 the the DT cord-023095-4dannjjm 6134 31 efficacy efficacy NN cord-023095-4dannjjm 6134 32 of of IN cord-023095-4dannjjm 6134 33 xenogeneic xenogeneic NNP cord-023095-4dannjjm 6134 34 antibodies antibody NNS cord-023095-4dannjjm 6134 35 in in IN cord-023095-4dannjjm 6134 36 the the DT cord-023095-4dannjjm 6134 37 dog dog NN cord-023095-4dannjjm 6134 38 is be VBZ cord-023095-4dannjjm 6134 39 limited limit VBN cord-023095-4dannjjm 6134 40 by by IN cord-023095-4dannjjm 6134 41 neutralizing neutralize VBG cord-023095-4dannjjm 6134 42 antibody antibody NN cord-023095-4dannjjm 6134 43 responses response NNS cord-023095-4dannjjm 6134 44 . . . cord-023095-4dannjjm 6135 1 To to TO cord-023095-4dannjjm 6135 2 overcome overcome VB cord-023095-4dannjjm 6135 3 these these DT cord-023095-4dannjjm 6135 4 obstacles obstacle NNS cord-023095-4dannjjm 6135 5 , , , cord-023095-4dannjjm 6135 6 we -PRON- PRP cord-023095-4dannjjm 6135 7 have have VBP cord-023095-4dannjjm 6135 8 generated generate VBN cord-023095-4dannjjm 6135 9 canine canine JJ cord-023095-4dannjjm 6135 10 antibody antibody NN cord-023095-4dannjjm 6135 11 phage phage NN cord-023095-4dannjjm 6135 12 display display NN cord-023095-4dannjjm 6135 13 libraries library NNS cord-023095-4dannjjm 6135 14 from from IN cord-023095-4dannjjm 6135 15 canine canine JJ cord-023095-4dannjjm 6135 16 splenocytes splenocyte NNS cord-023095-4dannjjm 6135 17 . . . cord-023095-4dannjjm 6136 1 These these DT cord-023095-4dannjjm 6136 2 libraries library NNS cord-023095-4dannjjm 6136 3 consist consist VBP cord-023095-4dannjjm 6136 4 of of IN cord-023095-4dannjjm 6136 5 single single JJ cord-023095-4dannjjm 6136 6 chain chain NN cord-023095-4dannjjm 6136 7 variable variable NN cord-023095-4dannjjm 6136 8 fragments fragment NNS cord-023095-4dannjjm 6136 9 ( ( -LRB- cord-023095-4dannjjm 6136 10 scFv scFv NNP cord-023095-4dannjjm 6136 11 ) ) -RRB- cord-023095-4dannjjm 6136 12 comprised comprise VBN cord-023095-4dannjjm 6136 13 of of IN cord-023095-4dannjjm 6136 14 canine canine JJ cord-023095-4dannjjm 6136 15 variable variable NN cord-023095-4dannjjm 6136 16 heavy heavy JJ cord-023095-4dannjjm 6136 17 ( ( -LRB- cord-023095-4dannjjm 6136 18 VH VH NNP cord-023095-4dannjjm 6136 19 ) ) -RRB- cord-023095-4dannjjm 6136 20 and and CC cord-023095-4dannjjm 6136 21 variable variable JJ cord-023095-4dannjjm 6136 22 light light NN cord-023095-4dannjjm 6136 23 ( ( -LRB- cord-023095-4dannjjm 6136 24 VL VL NNP cord-023095-4dannjjm 6136 25 ) ) -RRB- cord-023095-4dannjjm 6137 1 immunoglobulin immunoglobulin NN cord-023095-4dannjjm 6137 2 chains chain NNS cord-023095-4dannjjm 6137 3 displayed display VBN cord-023095-4dannjjm 6137 4 on on IN cord-023095-4dannjjm 6137 5 the the DT cord-023095-4dannjjm 6137 6 surface surface NN cord-023095-4dannjjm 6137 7 of of IN cord-023095-4dannjjm 6137 8 bacteriophage bacteriophage NN cord-023095-4dannjjm 6137 9 ( ( -LRB- cord-023095-4dannjjm 6137 10 Fig Fig NNP cord-023095-4dannjjm 6137 11 . . . cord-023095-4dannjjm 6137 12 1 1 CD cord-023095-4dannjjm 6137 13 ) ) -RRB- cord-023095-4dannjjm 6137 14 . . . cord-023095-4dannjjm 6138 1 The the DT cord-023095-4dannjjm 6138 2 antigen antigen NN cord-023095-4dannjjm 6138 3 specificity specificity NN cord-023095-4dannjjm 6138 4 within within IN cord-023095-4dannjjm 6138 5 these these DT cord-023095-4dannjjm 6138 6 libraries library NNS cord-023095-4dannjjm 6138 7 is be VBZ cord-023095-4dannjjm 6138 8 diverse diverse JJ cord-023095-4dannjjm 6138 9 and and CC cord-023095-4dannjjm 6138 10 recapitulates recapitulate VBZ cord-023095-4dannjjm 6138 11 the the DT cord-023095-4dannjjm 6138 12 antigen antigen NN cord-023095-4dannjjm 6138 13 - - HYPH cord-023095-4dannjjm 6138 14 experienced experience VBN cord-023095-4dannjjm 6138 15 immunoglobulin immunoglobulin NN cord-023095-4dannjjm 6138 16 repertoire repertoire NN cord-023095-4dannjjm 6138 17 of of IN cord-023095-4dannjjm 6138 18 the the DT cord-023095-4dannjjm 6138 19 dog dog NN cord-023095-4dannjjm 6138 20 . . . cord-023095-4dannjjm 6139 1 We -PRON- PRP cord-023095-4dannjjm 6139 2 can can MD cord-023095-4dannjjm 6139 3 now now RB cord-023095-4dannjjm 6139 4 use use VB cord-023095-4dannjjm 6139 5 simple simple JJ cord-023095-4dannjjm 6139 6 panning panning NN cord-023095-4dannjjm 6139 7 techniques technique NNS cord-023095-4dannjjm 6139 8 to to TO cord-023095-4dannjjm 6139 9 isolate isolate VB cord-023095-4dannjjm 6139 10 scFv scFv NNS cord-023095-4dannjjm 6139 11 of of IN cord-023095-4dannjjm 6139 12 canine canine JJ cord-023095-4dannjjm 6139 13 origin origin NN cord-023095-4dannjjm 6139 14 that that WDT cord-023095-4dannjjm 6139 15 bind bind VBP cord-023095-4dannjjm 6139 16 to to IN cord-023095-4dannjjm 6139 17 either either CC cord-023095-4dannjjm 6139 18 known know VBN cord-023095-4dannjjm 6139 19 targets target NNS cord-023095-4dannjjm 6139 20 or or CC cord-023095-4dannjjm 6139 21 unknown unknown JJ cord-023095-4dannjjm 6139 22 targets target NNS cord-023095-4dannjjm 6139 23 which which WDT cord-023095-4dannjjm 6139 24 can can MD cord-023095-4dannjjm 6139 25 then then RB cord-023095-4dannjjm 6139 26 be be VB cord-023095-4dannjjm 6139 27 identified identify VBN cord-023095-4dannjjm 6139 28 using use VBG cord-023095-4dannjjm 6139 29 standard standard JJ cord-023095-4dannjjm 6139 30 molecular molecular JJ cord-023095-4dannjjm 6139 31 techniques technique NNS cord-023095-4dannjjm 6139 32 . . . cord-023095-4dannjjm 6140 1 Canine canine JJ cord-023095-4dannjjm 6140 2 HSA HSA NNP cord-023095-4dannjjm 6140 3 is be VBZ cord-023095-4dannjjm 6140 4 a a DT cord-023095-4dannjjm 6140 5 highly highly RB cord-023095-4dannjjm 6140 6 aggressive aggressive JJ cord-023095-4dannjjm 6140 7 malignancy malignancy NN cord-023095-4dannjjm 6140 8 of of IN cord-023095-4dannjjm 6140 9 vascular vascular JJ cord-023095-4dannjjm 6140 10 endothelial endothelial JJ cord-023095-4dannjjm 6140 11 cells cell NNS cord-023095-4dannjjm 6140 12 that that WDT cord-023095-4dannjjm 6140 13 affects affect VBZ cord-023095-4dannjjm 6140 14 large large JJ cord-023095-4dannjjm 6140 15 breed breed NN cord-023095-4dannjjm 6140 16 dogs dog NNS cord-023095-4dannjjm 6140 17 . . . cord-023095-4dannjjm 6141 1 Although although IN cord-023095-4dannjjm 6141 2 there there EX cord-023095-4dannjjm 6141 3 are be VBP cord-023095-4dannjjm 6141 4 no no DT cord-023095-4dannjjm 6141 5 confirmed confirm VBN cord-023095-4dannjjm 6141 6 immunological immunological JJ cord-023095-4dannjjm 6141 7 targets target NNS cord-023095-4dannjjm 6141 8 for for IN cord-023095-4dannjjm 6141 9 HSA HSA NNP cord-023095-4dannjjm 6141 10 , , , cord-023095-4dannjjm 6141 11 serum serum NN cord-023095-4dannjjm 6141 12 levels level NNS cord-023095-4dannjjm 6141 13 of of IN cord-023095-4dannjjm 6141 14 Vascular vascular JJ cord-023095-4dannjjm 6141 15 Endothelial Endothelial NNP cord-023095-4dannjjm 6141 16 Growth Growth NNP cord-023095-4dannjjm 6141 17 Factor factor NN cord-023095-4dannjjm 6141 18 ( ( -LRB- cord-023095-4dannjjm 6141 19 VEGF VEGF NNP cord-023095-4dannjjm 6141 20 ) ) -RRB- cord-023095-4dannjjm 6141 21 are be VBP cord-023095-4dannjjm 6141 22 elevated elevate VBN cord-023095-4dannjjm 6141 23 in in IN cord-023095-4dannjjm 6141 24 these these DT cord-023095-4dannjjm 6141 25 patients patient NNS cord-023095-4dannjjm 6141 26 and and CC cord-023095-4dannjjm 6141 27 , , , cord-023095-4dannjjm 6141 28 as as IN cord-023095-4dannjjm 6141 29 in in IN cord-023095-4dannjjm 6141 30 many many JJ cord-023095-4dannjjm 6141 31 human human JJ cord-023095-4dannjjm 6141 32 cancers cancer NNS cord-023095-4dannjjm 6141 33 , , , cord-023095-4dannjjm 6141 34 VEGF VEGF NNP cord-023095-4dannjjm 6141 35 may may MD cord-023095-4dannjjm 6141 36 represent represent VB cord-023095-4dannjjm 6141 37 an an DT cord-023095-4dannjjm 6141 38 important important JJ cord-023095-4dannjjm 6141 39 therapeutic therapeutic JJ cord-023095-4dannjjm 6141 40 target target NN cord-023095-4dannjjm 6141 41 for for IN cord-023095-4dannjjm 6141 42 neutralization neutralization NN cord-023095-4dannjjm 6141 43 . . . cord-023095-4dannjjm 6142 1 We -PRON- PRP cord-023095-4dannjjm 6142 2 used use VBD cord-023095-4dannjjm 6142 3 simple simple JJ cord-023095-4dannjjm 6142 4 panning panning NN cord-023095-4dannjjm 6142 5 techniques technique NNS cord-023095-4dannjjm 6142 6 to to TO cord-023095-4dannjjm 6142 7 screen screen VB cord-023095-4dannjjm 6142 8 canine canine JJ cord-023095-4dannjjm 6142 9 scFv scFv NNP cord-023095-4dannjjm 6142 10 libraries library NNS cord-023095-4dannjjm 6142 11 generated generate VBN cord-023095-4dannjjm 6142 12 from from IN cord-023095-4dannjjm 6142 13 the the DT cord-023095-4dannjjm 6142 14 spleens spleen NNS cord-023095-4dannjjm 6142 15 of of IN cord-023095-4dannjjm 6142 16 dogs dog NNS cord-023095-4dannjjm 6142 17 with with IN cord-023095-4dannjjm 6142 18 HSA HSA NNP cord-023095-4dannjjm 6142 19 against against IN cord-023095-4dannjjm 6142 20 canine canine JJ cord-023095-4dannjjm 6142 21 VEGF vegf NN cord-023095-4dannjjm 6142 22 and and CC cord-023095-4dannjjm 6142 23 successfully successfully RB cord-023095-4dannjjm 6142 24 isolated isolate VBN cord-023095-4dannjjm 6142 25 3 3 CD cord-023095-4dannjjm 6142 26 scFv scfv JJ cord-023095-4dannjjm 6142 27 clones clone NNS cord-023095-4dannjjm 6142 28 that that WDT cord-023095-4dannjjm 6142 29 bind bind VBP cord-023095-4dannjjm 6142 30 and and CC cord-023095-4dannjjm 6142 31 neutralize neutralize VB cord-023095-4dannjjm 6142 32 canine canine JJ cord-023095-4dannjjm 6142 33 VEGF vegf NN cord-023095-4dannjjm 6142 34 in in IN cord-023095-4dannjjm 6142 35 vitro vitro FW cord-023095-4dannjjm 6142 36 . . . cord-023095-4dannjjm 6143 1 These these DT cord-023095-4dannjjm 6143 2 scFvs scfv NNS cord-023095-4dannjjm 6143 3 are be VBP cord-023095-4dannjjm 6143 4 now now RB cord-023095-4dannjjm 6143 5 being be VBG cord-023095-4dannjjm 6143 6 taken take VBN cord-023095-4dannjjm 6143 7 into into IN cord-023095-4dannjjm 6143 8 a a DT cord-023095-4dannjjm 6143 9 murine murine JJ cord-023095-4dannjjm 6143 10 model model NN cord-023095-4dannjjm 6143 11 of of IN cord-023095-4dannjjm 6143 12 canine canine JJ cord-023095-4dannjjm 6143 13 HSA HSA NNP cord-023095-4dannjjm 6143 14 to to TO cord-023095-4dannjjm 6143 15 determine determine VB cord-023095-4dannjjm 6143 16 whether whether IN cord-023095-4dannjjm 6143 17 they -PRON- PRP cord-023095-4dannjjm 6143 18 can can MD cord-023095-4dannjjm 6143 19 inhibit inhibit VB cord-023095-4dannjjm 6143 20 tumor tumor NN cord-023095-4dannjjm 6143 21 growth growth NN cord-023095-4dannjjm 6143 22 and and CC cord-023095-4dannjjm 6143 23 metastases metastasis NNS cord-023095-4dannjjm 6143 24 . . . cord-023095-4dannjjm 6144 1 In in IN cord-023095-4dannjjm 6144 2 addition addition NN cord-023095-4dannjjm 6144 3 , , , cord-023095-4dannjjm 6144 4 we -PRON- PRP cord-023095-4dannjjm 6144 5 have have VBP cord-023095-4dannjjm 6144 6 panned pan VBN cord-023095-4dannjjm 6144 7 the the DT cord-023095-4dannjjm 6144 8 same same JJ cord-023095-4dannjjm 6144 9 antigen antigen NN cord-023095-4dannjjm 6144 10 - - HYPH cord-023095-4dannjjm 6144 11 experienced experience VBN cord-023095-4dannjjm 6144 12 scFv scFv HYPH cord-023095-4dannjjm 6144 13 phage phage NN cord-023095-4dannjjm 6144 14 display display NN cord-023095-4dannjjm 6144 15 libraries library NNS cord-023095-4dannjjm 6144 16 against against IN cord-023095-4dannjjm 6144 17 allogeneic allogeneic JJ cord-023095-4dannjjm 6144 18 primary primary JJ cord-023095-4dannjjm 6144 19 canine canine JJ cord-023095-4dannjjm 6144 20 HSA HSA NNP cord-023095-4dannjjm 6144 21 cells cell NNS cord-023095-4dannjjm 6144 22 of of IN cord-023095-4dannjjm 6144 23 low low JJ cord-023095-4dannjjm 6144 24 passage passage NN cord-023095-4dannjjm 6144 25 number number NN cord-023095-4dannjjm 6144 26 to to TO cord-023095-4dannjjm 6144 27 isolate isolate VB cord-023095-4dannjjm 6144 28 canine canine NN cord-023095-4dannjjm 6144 29 - - HYPH cord-023095-4dannjjm 6144 30 derived derive VBN cord-023095-4dannjjm 6144 31 antibody antibody NN cord-023095-4dannjjm 6144 32 fragments fragment NNS cord-023095-4dannjjm 6144 33 that that WDT cord-023095-4dannjjm 6144 34 can can MD cord-023095-4dannjjm 6144 35 target target VB cord-023095-4dannjjm 6144 36 malignant malignant JJ cord-023095-4dannjjm 6144 37 endothelial endothelial JJ cord-023095-4dannjjm 6144 38 cell cell NN cord-023095-4dannjjm 6144 39 surface surface NN cord-023095-4dannjjm 6144 40 molecules molecule NNS cord-023095-4dannjjm 6144 41 . . . cord-023095-4dannjjm 6145 1 Early early JJ cord-023095-4dannjjm 6145 2 results result NNS cord-023095-4dannjjm 6145 3 demonstrate demonstrate VBP cord-023095-4dannjjm 6145 4 enrichment enrichment NN cord-023095-4dannjjm 6145 5 of of IN cord-023095-4dannjjm 6145 6 scFv scfv JJ cord-023095-4dannjjm 6145 7 phage phage NN cord-023095-4dannjjm 6145 8 libraries library NNS cord-023095-4dannjjm 6145 9 for for IN cord-023095-4dannjjm 6145 10 malignant malignant JJ cord-023095-4dannjjm 6145 11 endothelial endothelial JJ cord-023095-4dannjjm 6145 12 cell cell NN cord-023095-4dannjjm 6145 13 binders binder NNS cord-023095-4dannjjm 6145 14 . . . cord-023095-4dannjjm 6146 1 These these DT cord-023095-4dannjjm 6146 2 scFv scFv NNS cord-023095-4dannjjm 6146 3 can can MD cord-023095-4dannjjm 6146 4 be be VB cord-023095-4dannjjm 6146 5 readily readily RB cord-023095-4dannjjm 6146 6 linked link VBN cord-023095-4dannjjm 6146 7 to to IN cord-023095-4dannjjm 6146 8 chemotherapeutic chemotherapeutic JJ cord-023095-4dannjjm 6146 9 agents agent NNS cord-023095-4dannjjm 6146 10 or or CC cord-023095-4dannjjm 6146 11 other other JJ cord-023095-4dannjjm 6146 12 toxins toxin NNS cord-023095-4dannjjm 6146 13 and and CC cord-023095-4dannjjm 6146 14 used use VBD cord-023095-4dannjjm 6146 15 to to TO cord-023095-4dannjjm 6146 16 deliver deliver VB cord-023095-4dannjjm 6146 17 high high JJ cord-023095-4dannjjm 6146 18 doses dose NNS cord-023095-4dannjjm 6146 19 directly directly RB cord-023095-4dannjjm 6146 20 to to IN cord-023095-4dannjjm 6146 21 the the DT cord-023095-4dannjjm 6146 22 malignant malignant JJ cord-023095-4dannjjm 6146 23 cell cell NN cord-023095-4dannjjm 6146 24 . . . cord-023095-4dannjjm 6147 1 This this DT cord-023095-4dannjjm 6147 2 novel novel JJ cord-023095-4dannjjm 6147 3 approach approach NN cord-023095-4dannjjm 6147 4 aims aim VBZ cord-023095-4dannjjm 6147 5 to to TO cord-023095-4dannjjm 6147 6 reduce reduce VB cord-023095-4dannjjm 6147 7 side side NN cord-023095-4dannjjm 6147 8 effects effect NNS cord-023095-4dannjjm 6147 9 of of IN cord-023095-4dannjjm 6147 10 systemic systemic JJ cord-023095-4dannjjm 6147 11 chemotherapy chemotherapy NN cord-023095-4dannjjm 6147 12 and and CC cord-023095-4dannjjm 6147 13 augment augment VB cord-023095-4dannjjm 6147 14 therapeutic therapeutic JJ cord-023095-4dannjjm 6147 15 response response NN cord-023095-4dannjjm 6147 16 . . . cord-023095-4dannjjm 6148 1 Calcitriol Calcitriol NNP cord-023095-4dannjjm 6148 2 , , , cord-023095-4dannjjm 6148 3 ( ( -LRB- cord-023095-4dannjjm 6148 4 vitamin vitamin NN cord-023095-4dannjjm 6148 5 D D NNP cord-023095-4dannjjm 6148 6 3 3 CD cord-023095-4dannjjm 6148 7 ) ) -RRB- cord-023095-4dannjjm 6148 8 , , , cord-023095-4dannjjm 6148 9 has have VBZ cord-023095-4dannjjm 6148 10 antineoplastic antineoplastic JJ cord-023095-4dannjjm 6148 11 activity activity NN cord-023095-4dannjjm 6148 12 and and CC cord-023095-4dannjjm 6148 13 acts act VBZ cord-023095-4dannjjm 6148 14 synergistically synergistically RB cord-023095-4dannjjm 6148 15 to to TO cord-023095-4dannjjm 6148 16 potentiate potentiate VB cord-023095-4dannjjm 6148 17 the the DT cord-023095-4dannjjm 6148 18 antitumor antitumor JJ cord-023095-4dannjjm 6148 19 activity activity NN cord-023095-4dannjjm 6148 20 of of IN cord-023095-4dannjjm 6148 21 a a DT cord-023095-4dannjjm 6148 22 diverse diverse JJ cord-023095-4dannjjm 6148 23 array array NN cord-023095-4dannjjm 6148 24 of of IN cord-023095-4dannjjm 6148 25 chemotherapeutics chemotherapeutic NNS cord-023095-4dannjjm 6148 26 . . . cord-023095-4dannjjm 6149 1 CCNU CCNU NNP cord-023095-4dannjjm 6149 2 , , , cord-023095-4dannjjm 6149 3 vinblastine vinblastine NN cord-023095-4dannjjm 6149 4 , , , cord-023095-4dannjjm 6149 5 corticosteroids corticosteroid NNS cord-023095-4dannjjm 6149 6 , , , cord-023095-4dannjjm 6149 7 and and CC cord-023095-4dannjjm 6149 8 tyrosine tyrosine NN cord-023095-4dannjjm 6149 9 kinase kinase NN cord-023095-4dannjjm 6149 10 inhibitors inhibitor NNS cord-023095-4dannjjm 6149 11 , , , cord-023095-4dannjjm 6149 12 are be VBP cord-023095-4dannjjm 6149 13 used use VBN cord-023095-4dannjjm 6149 14 to to TO cord-023095-4dannjjm 6149 15 treat treat VB cord-023095-4dannjjm 6149 16 canine canine JJ cord-023095-4dannjjm 6149 17 mast mast NN cord-023095-4dannjjm 6149 18 cell cell NN cord-023095-4dannjjm 6149 19 tumors tumor NNS cord-023095-4dannjjm 6149 20 ( ( -LRB- cord-023095-4dannjjm 6149 21 MCT MCT NNP cord-023095-4dannjjm 6149 22 ) ) -RRB- cord-023095-4dannjjm 6149 23 . . . cord-023095-4dannjjm 6150 1 Vitamin vitamin NN cord-023095-4dannjjm 6150 2 D d NN cord-023095-4dannjjm 6150 3 receptor receptor NN cord-023095-4dannjjm 6150 4 is be VBZ cord-023095-4dannjjm 6150 5 expressed express VBN cord-023095-4dannjjm 6150 6 in in IN cord-023095-4dannjjm 6150 7 the the DT cord-023095-4dannjjm 6150 8 majority majority NN cord-023095-4dannjjm 6150 9 of of IN cord-023095-4dannjjm 6150 10 canine canine JJ cord-023095-4dannjjm 6150 11 MCTs mct NNS cord-023095-4dannjjm 6150 12 , , , cord-023095-4dannjjm 6150 13 suggesting suggest VBG cord-023095-4dannjjm 6150 14 a a DT cord-023095-4dannjjm 6150 15 role role NN cord-023095-4dannjjm 6150 16 for for IN cord-023095-4dannjjm 6150 17 calcitriol calcitriol NN cord-023095-4dannjjm 6150 18 in in IN cord-023095-4dannjjm 6150 19 the the DT cord-023095-4dannjjm 6150 20 management management NN cord-023095-4dannjjm 6150 21 of of IN cord-023095-4dannjjm 6150 22 dogs dog NNS cord-023095-4dannjjm 6150 23 with with IN cord-023095-4dannjjm 6150 24 these these DT cord-023095-4dannjjm 6150 25 tumors tumor NNS cord-023095-4dannjjm 6150 26 . . . cord-023095-4dannjjm 6151 1 The the DT cord-023095-4dannjjm 6151 2 purpose purpose NN cord-023095-4dannjjm 6151 3 of of IN cord-023095-4dannjjm 6151 4 our -PRON- PRP$ cord-023095-4dannjjm 6151 5 study study NN cord-023095-4dannjjm 6151 6 was be VBD cord-023095-4dannjjm 6151 7 to to TO cord-023095-4dannjjm 6151 8 examine examine VB cord-023095-4dannjjm 6151 9 the the DT cord-023095-4dannjjm 6151 10 in in FW cord-023095-4dannjjm 6151 11 vitro vitro FW cord-023095-4dannjjm 6151 12 effects effect NNS cord-023095-4dannjjm 6151 13 of of IN cord-023095-4dannjjm 6151 14 calcitriol calcitriol NN cord-023095-4dannjjm 6151 15 in in IN cord-023095-4dannjjm 6151 16 combination combination NN cord-023095-4dannjjm 6151 17 with with IN cord-023095-4dannjjm 6151 18 CCNU CCNU NNP cord-023095-4dannjjm 6151 19 , , , cord-023095-4dannjjm 6151 20 vinblastine vinblastine NN cord-023095-4dannjjm 6151 21 , , , cord-023095-4dannjjm 6151 22 imatinib imatinib RB cord-023095-4dannjjm 6151 23 , , , cord-023095-4dannjjm 6151 24 or or CC cord-023095-4dannjjm 6151 25 toceranib toceranib NN cord-023095-4dannjjm 6151 26 on on IN cord-023095-4dannjjm 6151 27 canine canine JJ cord-023095-4dannjjm 6151 28 mastocytoma mastocytoma NNP cord-023095-4dannjjm 6151 29 C2 C2 NNP cord-023095-4dannjjm 6151 30 cells cell NNS cord-023095-4dannjjm 6151 31 . . . cord-023095-4dannjjm 6152 1 Also also RB cord-023095-4dannjjm 6152 2 , , , cord-023095-4dannjjm 6152 3 we -PRON- PRP cord-023095-4dannjjm 6152 4 evaluated evaluate VBD cord-023095-4dannjjm 6152 5 the the DT cord-023095-4dannjjm 6152 6 antitumor antitumor JJ cord-023095-4dannjjm 6152 7 activity activity NN cord-023095-4dannjjm 6152 8 of of IN cord-023095-4dannjjm 6152 9 DN101 DN101 NNP cord-023095-4dannjjm 6152 10 , , , cord-023095-4dannjjm 6152 11 a a DT cord-023095-4dannjjm 6152 12 highly highly RB cord-023095-4dannjjm 6152 13 concentrated concentrated JJ cord-023095-4dannjjm 6152 14 oral oral JJ cord-023095-4dannjjm 6152 15 formulation formulation NN cord-023095-4dannjjm 6152 16 of of IN cord-023095-4dannjjm 6152 17 calcitriol calcitriol NNP cord-023095-4dannjjm 6152 18 , , , cord-023095-4dannjjm 6152 19 as as IN cord-023095-4dannjjm 6152 20 single single JJ cord-023095-4dannjjm 6152 21 - - HYPH cord-023095-4dannjjm 6152 22 agent agent NN cord-023095-4dannjjm 6152 23 treatment treatment NN cord-023095-4dannjjm 6152 24 in in IN cord-023095-4dannjjm 6152 25 dogs dog NNS cord-023095-4dannjjm 6152 26 with with IN cord-023095-4dannjjm 6152 27 naturally naturally RB cord-023095-4dannjjm 6152 28 occurring occur VBG cord-023095-4dannjjm 6152 29 MCTs mct NNS cord-023095-4dannjjm 6152 30 . . . cord-023095-4dannjjm 6153 1 C2 C2 NNP cord-023095-4dannjjm 6153 2 cells cell NNS cord-023095-4dannjjm 6153 3 were be VBD cord-023095-4dannjjm 6153 4 incubated incubate VBN cord-023095-4dannjjm 6153 5 with with IN cord-023095-4dannjjm 6153 6 serial serial JJ cord-023095-4dannjjm 6153 7 dilutions dilution NNS cord-023095-4dannjjm 6153 8 of of IN cord-023095-4dannjjm 6153 9 calcitriol calcitriol NN cord-023095-4dannjjm 6153 10 ( ( -LRB- cord-023095-4dannjjm 6153 11 0.1 0.1 CD cord-023095-4dannjjm 6153 12 - - SYM cord-023095-4dannjjm 6153 13 25 25 CD cord-023095-4dannjjm 6153 14 nM nm CD cord-023095-4dannjjm 6153 15 ) ) -RRB- cord-023095-4dannjjm 6153 16 . . . cord-023095-4dannjjm 6154 1 Twenty twenty CD cord-023095-4dannjjm 6154 2 - - HYPH cord-023095-4dannjjm 6154 3 four four CD cord-023095-4dannjjm 6154 4 hours hour NNS cord-023095-4dannjjm 6154 5 later later RB cord-023095-4dannjjm 6154 6 , , , cord-023095-4dannjjm 6154 7 cells cell NNS cord-023095-4dannjjm 6154 8 were be VBD cord-023095-4dannjjm 6154 9 then then RB cord-023095-4dannjjm 6154 10 treated treat VBN cord-023095-4dannjjm 6154 11 with with IN cord-023095-4dannjjm 6154 12 vehicle vehicle NN cord-023095-4dannjjm 6154 13 control control NN cord-023095-4dannjjm 6154 14 or or CC cord-023095-4dannjjm 6154 15 serial serial JJ cord-023095-4dannjjm 6154 16 dilutions dilution NNS cord-023095-4dannjjm 6154 17 of of IN cord-023095-4dannjjm 6154 18 CCNU CCNU NNP cord-023095-4dannjjm 6154 19 ( ( -LRB- cord-023095-4dannjjm 6154 20 2.5 2.5 CD cord-023095-4dannjjm 6154 21 - - SYM cord-023095-4dannjjm 6154 22 20 20 CD cord-023095-4dannjjm 6154 23 uM um UH cord-023095-4dannjjm 6154 24 ) ) -RRB- cord-023095-4dannjjm 6154 25 , , , cord-023095-4dannjjm 6154 26 vinblastine vinblastine NN cord-023095-4dannjjm 6154 27 ( ( -LRB- cord-023095-4dannjjm 6154 28 1.25 1.25 CD cord-023095-4dannjjm 6154 29 - - SYM cord-023095-4dannjjm 6154 30 10 10 CD cord-023095-4dannjjm 6154 31 nM nM NNP cord-023095-4dannjjm 6154 32 ) ) -RRB- cord-023095-4dannjjm 6154 33 , , , cord-023095-4dannjjm 6154 34 imatinib imatinib JJ cord-023095-4dannjjm 6154 35 ( ( -LRB- cord-023095-4dannjjm 6154 36 1.67 1.67 CD cord-023095-4dannjjm 6154 37 - - SYM cord-023095-4dannjjm 6154 38 12.5 12.5 CD cord-023095-4dannjjm 6154 39 nM nM NNP cord-023095-4dannjjm 6154 40 ) ) -RRB- cord-023095-4dannjjm 6154 41 , , , cord-023095-4dannjjm 6154 42 or or CC cord-023095-4dannjjm 6154 43 toceranib toceranib NNP cord-023095-4dannjjm 6154 44 ( ( -LRB- cord-023095-4dannjjm 6154 45 3.13 3.13 CD cord-023095-4dannjjm 6154 46 - - SYM cord-023095-4dannjjm 6154 47 25 25 CD cord-023095-4dannjjm 6154 48 nM nM NNP cord-023095-4dannjjm 6154 49 ) ) -RRB- cord-023095-4dannjjm 6154 50 . . . cord-023095-4dannjjm 6155 1 Cell cell NN cord-023095-4dannjjm 6155 2 viability viability NN cord-023095-4dannjjm 6155 3 was be VBD cord-023095-4dannjjm 6155 4 assessed assess VBN cord-023095-4dannjjm 6155 5 with with IN cord-023095-4dannjjm 6155 6 an an DT cord-023095-4dannjjm 6155 7 MTT MTT NNP cord-023095-4dannjjm 6155 8 assay assay NN cord-023095-4dannjjm 6155 9 after after IN cord-023095-4dannjjm 6155 10 48 48 CD cord-023095-4dannjjm 6155 11 hours hour NNS cord-023095-4dannjjm 6155 12 and and CC cord-023095-4dannjjm 6155 13 data datum NNS cord-023095-4dannjjm 6155 14 was be VBD cord-023095-4dannjjm 6155 15 used use VBN cord-023095-4dannjjm 6155 16 to to TO cord-023095-4dannjjm 6155 17 derive derive VB cord-023095-4dannjjm 6155 18 a a DT cord-023095-4dannjjm 6155 19 combination combination NN cord-023095-4dannjjm 6155 20 index index NN cord-023095-4dannjjm 6155 21 ( ( -LRB- cord-023095-4dannjjm 6155 22 CI CI NNP cord-023095-4dannjjm 6155 23 : : : cord-023095-4dannjjm 6155 24 values value NNS cord-023095-4dannjjm 6155 25 o o NNP cord-023095-4dannjjm 6155 26 1 1 CD cord-023095-4dannjjm 6155 27 , , , cord-023095-4dannjjm 6155 28 1 1 CD cord-023095-4dannjjm 6155 29 , , , cord-023095-4dannjjm 6155 30 41 41 CD cord-023095-4dannjjm 6155 31 indicate indicate VBP cord-023095-4dannjjm 6155 32 synergism synergism NN cord-023095-4dannjjm 6155 33 , , , cord-023095-4dannjjm 6155 34 additivity additivity NN cord-023095-4dannjjm 6155 35 , , , cord-023095-4dannjjm 6155 36 antagonism antagonism NN cord-023095-4dannjjm 6155 37 , , , cord-023095-4dannjjm 6155 38 respectively respectively RB cord-023095-4dannjjm 6155 39 ) ) -RRB- cord-023095-4dannjjm 6155 40 . . . cord-023095-4dannjjm 6156 1 In in IN cord-023095-4dannjjm 6156 2 the the DT cord-023095-4dannjjm 6156 3 phase phase NN cord-023095-4dannjjm 6156 4 II ii CD cord-023095-4dannjjm 6156 5 clinical clinical JJ cord-023095-4dannjjm 6156 6 trial trial NN cord-023095-4dannjjm 6156 7 , , , cord-023095-4dannjjm 6156 8 dogs dog NNS cord-023095-4dannjjm 6156 9 were be VBD cord-023095-4dannjjm 6156 10 eligible eligible JJ cord-023095-4dannjjm 6156 11 if if IN cord-023095-4dannjjm 6156 12 they -PRON- PRP cord-023095-4dannjjm 6156 13 had have VBD cord-023095-4dannjjm 6156 14 at at RB cord-023095-4dannjjm 6156 15 least least JJS cord-023095-4dannjjm 6156 16 1 1 CD cord-023095-4dannjjm 6156 17 measurable measurable JJ cord-023095-4dannjjm 6156 18 , , , cord-023095-4dannjjm 6156 19 histologically histologically RB cord-023095-4dannjjm 6156 20 confirmed confirm VBD cord-023095-4dannjjm 6156 21 , , , cord-023095-4dannjjm 6156 22 MCT MCT NNP cord-023095-4dannjjm 6156 23 . . . cord-023095-4dannjjm 6157 1 Calcitriol Calcitriol NNP cord-023095-4dannjjm 6157 2 was be VBD cord-023095-4dannjjm 6157 3 administered administer VBN cord-023095-4dannjjm 6157 4 orally orally RB cord-023095-4dannjjm 6157 5 . . . cord-023095-4dannjjm 6158 1 RECIST RECIST NNP cord-023095-4dannjjm 6158 2 criteria criterion NNS cord-023095-4dannjjm 6158 3 were be VBD cord-023095-4dannjjm 6158 4 used use VBN cord-023095-4dannjjm 6158 5 to to TO cord-023095-4dannjjm 6158 6 assess assess VB cord-023095-4dannjjm 6158 7 tumor tumor NN cord-023095-4dannjjm 6158 8 response response NN cord-023095-4dannjjm 6158 9 . . . cord-023095-4dannjjm 6159 1 Calcitriol Calcitriol NNP cord-023095-4dannjjm 6159 2 , , , cord-023095-4dannjjm 6159 3 CCNU CCNU NNP cord-023095-4dannjjm 6159 4 , , , cord-023095-4dannjjm 6159 5 vinblastine vinblastine NN cord-023095-4dannjjm 6159 6 , , , cord-023095-4dannjjm 6159 7 imatinib imatinib RB cord-023095-4dannjjm 6159 8 , , , cord-023095-4dannjjm 6159 9 and and CC cord-023095-4dannjjm 6159 10 toceranib toceranib NNP cord-023095-4dannjjm 6159 11 each each DT cord-023095-4dannjjm 6159 12 suppressed suppress VBD cord-023095-4dannjjm 6159 13 C2 C2 NNP cord-023095-4dannjjm 6159 14 cell cell NN cord-023095-4dannjjm 6159 15 viability viability NN cord-023095-4dannjjm 6159 16 in in IN cord-023095-4dannjjm 6159 17 a a DT cord-023095-4dannjjm 6159 18 dose dose NN cord-023095-4dannjjm 6159 19 - - HYPH cord-023095-4dannjjm 6159 20 dependent dependent JJ cord-023095-4dannjjm 6159 21 manner manner NN cord-023095-4dannjjm 6159 22 . . . cord-023095-4dannjjm 6160 1 CI CI NNP cord-023095-4dannjjm 6160 2 values value NNS cord-023095-4dannjjm 6161 1 o o LS cord-023095-4dannjjm 6161 2 1 1 CD cord-023095-4dannjjm 6161 3 were be VBD cord-023095-4dannjjm 6161 4 obtained obtain VBN cord-023095-4dannjjm 6161 5 for for IN cord-023095-4dannjjm 6161 6 calcitriol calcitriol NN cord-023095-4dannjjm 6161 7 ( ( -LRB- cord-023095-4dannjjm 6161 8 0.1 0.1 CD cord-023095-4dannjjm 6161 9 - - SYM cord-023095-4dannjjm 6161 10 6.25 6.25 CD cord-023095-4dannjjm 6161 11 nM nm NN cord-023095-4dannjjm 6161 12 ) ) -RRB- cord-023095-4dannjjm 6161 13 combined combine VBN cord-023095-4dannjjm 6161 14 with with IN cord-023095-4dannjjm 6161 15 CCNU CCNU NNP cord-023095-4dannjjm 6161 16 ( ( -LRB- cord-023095-4dannjjm 6161 17 5 5 CD cord-023095-4dannjjm 6161 18 and and CC cord-023095-4dannjjm 6161 19 10uM 10um CD cord-023095-4dannjjm 6161 20 ) ) -RRB- cord-023095-4dannjjm 6161 21 , , , cord-023095-4dannjjm 6161 22 vinblastine vinblastine FW cord-023095-4dannjjm 6161 23 ( ( -LRB- cord-023095-4dannjjm 6161 24 2.5 2.5 CD cord-023095-4dannjjm 6161 25 and and CC cord-023095-4dannjjm 6161 26 5 5 CD cord-023095-4dannjjm 6161 27 nM nm CD cord-023095-4dannjjm 6161 28 ) ) -RRB- cord-023095-4dannjjm 6161 29 , , , cord-023095-4dannjjm 6161 30 imatinib imatinib JJ cord-023095-4dannjjm 6161 31 ( ( -LRB- cord-023095-4dannjjm 6161 32 1.67 1.67 CD cord-023095-4dannjjm 6161 33 - - SYM cord-023095-4dannjjm 6161 34 12.5 12.5 CD cord-023095-4dannjjm 6161 35 nM nM NNP cord-023095-4dannjjm 6161 36 ) ) -RRB- cord-023095-4dannjjm 6161 37 and and CC cord-023095-4dannjjm 6161 38 toceranib toceranib NNP cord-023095-4dannjjm 6161 39 ( ( -LRB- cord-023095-4dannjjm 6161 40 0.1 0.1 CD cord-023095-4dannjjm 6161 41 - - SYM cord-023095-4dannjjm 6161 42 12.5 12.5 CD cord-023095-4dannjjm 6161 43 nM nm NN cord-023095-4dannjjm 6161 44 ) ) -RRB- cord-023095-4dannjjm 6161 45 . . . cord-023095-4dannjjm 6162 1 Due due IN cord-023095-4dannjjm 6162 2 to to IN cord-023095-4dannjjm 6162 3 the the DT cord-023095-4dannjjm 6162 4 occurrence occurrence NN cord-023095-4dannjjm 6162 5 of of IN cord-023095-4dannjjm 6162 6 toxicity toxicity NN cord-023095-4dannjjm 6162 7 ( ( -LRB- cord-023095-4dannjjm 6162 8 vomiting vomiting NN cord-023095-4dannjjm 6162 9 , , , cord-023095-4dannjjm 6162 10 anorexia anorexia NN cord-023095-4dannjjm 6162 11 , , , cord-023095-4dannjjm 6162 12 hypercalcemia hypercalcemia NN cord-023095-4dannjjm 6162 13 ) ) -RRB- cord-023095-4dannjjm 6162 14 , , , cord-023095-4dannjjm 6162 15 the the DT cord-023095-4dannjjm 6162 16 phase phase NN cord-023095-4dannjjm 6162 17 II II NNP cord-023095-4dannjjm 6162 18 trial trial NN cord-023095-4dannjjm 6162 19 was be VBD cord-023095-4dannjjm 6162 20 terminated terminate VBN cord-023095-4dannjjm 6162 21 early early RB cord-023095-4dannjjm 6162 22 ; ; : cord-023095-4dannjjm 6162 23 only only RB cord-023095-4dannjjm 6162 24 10 10 CD cord-023095-4dannjjm 6162 25 of of IN cord-023095-4dannjjm 6162 26 20 20 CD cord-023095-4dannjjm 6162 27 planned plan VBN cord-023095-4dannjjm 6162 28 patients patient NNS cord-023095-4dannjjm 6162 29 were be VBD cord-023095-4dannjjm 6162 30 treated treat VBN cord-023095-4dannjjm 6162 31 . . . cord-023095-4dannjjm 6163 1 One one CD cord-023095-4dannjjm 6163 2 dog dog NN cord-023095-4dannjjm 6163 3 with with IN cord-023095-4dannjjm 6163 4 a a DT cord-023095-4dannjjm 6163 5 metastatic metastatic JJ cord-023095-4dannjjm 6163 6 muzzle muzzle NN cord-023095-4dannjjm 6163 7 MCT MCT NNP cord-023095-4dannjjm 6163 8 had have VBD cord-023095-4dannjjm 6163 9 a a DT cord-023095-4dannjjm 6163 10 complete complete JJ cord-023095-4dannjjm 6163 11 response response NN cord-023095-4dannjjm 6163 12 that that WDT cord-023095-4dannjjm 6163 13 lasted last VBD cord-023095-4dannjjm 6163 14 89 89 CD cord-023095-4dannjjm 6163 15 days day NNS cord-023095-4dannjjm 6163 16 . . . cord-023095-4dannjjm 6164 1 Three three CD cord-023095-4dannjjm 6164 2 dogs dog NNS cord-023095-4dannjjm 6164 3 achieved achieve VBD cord-023095-4dannjjm 6164 4 partial partial JJ cord-023095-4dannjjm 6164 5 response response NN cord-023095-4dannjjm 6164 6 lasting last VBG cord-023095-4dannjjm 6164 7 from from IN cord-023095-4dannjjm 6164 8 74 74 CD cord-023095-4dannjjm 6164 9 - - SYM cord-023095-4dannjjm 6164 10 90 90 CD cord-023095-4dannjjm 6164 11 days day NNS cord-023095-4dannjjm 6164 12 . . . cord-023095-4dannjjm 6165 1 In in IN cord-023095-4dannjjm 6165 2 summary summary NN cord-023095-4dannjjm 6165 3 , , , cord-023095-4dannjjm 6165 4 our -PRON- PRP$ cord-023095-4dannjjm 6165 5 in in FW cord-023095-4dannjjm 6165 6 vitro vitro FW cord-023095-4dannjjm 6165 7 data datum NNS cord-023095-4dannjjm 6165 8 demonstrate demonstrate VBP cord-023095-4dannjjm 6165 9 that that IN cord-023095-4dannjjm 6165 10 calcitriol calcitriol NN cord-023095-4dannjjm 6165 11 combined combine VBN cord-023095-4dannjjm 6165 12 with with IN cord-023095-4dannjjm 6165 13 CCNU CCNU NNP cord-023095-4dannjjm 6165 14 , , , cord-023095-4dannjjm 6165 15 vinblastine vinblastine NN cord-023095-4dannjjm 6165 16 , , , cord-023095-4dannjjm 6165 17 imatinib imatinib NN cord-023095-4dannjjm 6165 18 or or CC cord-023095-4dannjjm 6165 19 toceranib toceranib NN cord-023095-4dannjjm 6165 20 has have VBZ cord-023095-4dannjjm 6165 21 synergistic synergistic JJ cord-023095-4dannjjm 6165 22 effects effect NNS cord-023095-4dannjjm 6165 23 on on IN cord-023095-4dannjjm 6165 24 C2 C2 NNP cord-023095-4dannjjm 6165 25 mastocytoma mastocytoma NNP cord-023095-4dannjjm 6165 26 cells cell NNS cord-023095-4dannjjm 6165 27 . . . cord-023095-4dannjjm 6166 1 Antitumor Antitumor NNP cord-023095-4dannjjm 6166 2 responses response NNS cord-023095-4dannjjm 6166 3 were be VBD cord-023095-4dannjjm 6166 4 observed observe VBN cord-023095-4dannjjm 6166 5 in in IN cord-023095-4dannjjm 6166 6 dogs dog NNS cord-023095-4dannjjm 6166 7 with with IN cord-023095-4dannjjm 6166 8 spontaneously spontaneously RB cord-023095-4dannjjm 6166 9 occurring occur VBG cord-023095-4dannjjm 6166 10 MCTs mct NNS cord-023095-4dannjjm 6166 11 treated treat VBN cord-023095-4dannjjm 6166 12 orally orally RB cord-023095-4dannjjm 6166 13 with with IN cord-023095-4dannjjm 6166 14 single single JJ cord-023095-4dannjjm 6166 15 - - HYPH cord-023095-4dannjjm 6166 16 agent agent NN cord-023095-4dannjjm 6166 17 calcitriol calcitriol NN cord-023095-4dannjjm 6166 18 , , , cord-023095-4dannjjm 6166 19 but but CC cord-023095-4dannjjm 6166 20 the the DT cord-023095-4dannjjm 6166 21 frequency frequency NN cord-023095-4dannjjm 6166 22 of of IN cord-023095-4dannjjm 6166 23 adverse adverse JJ cord-023095-4dannjjm 6166 24 effects effect NNS cord-023095-4dannjjm 6166 25 was be VBD cord-023095-4dannjjm 6166 26 high high JJ cord-023095-4dannjjm 6166 27 . . . cord-023095-4dannjjm 6167 1 Together together RB cord-023095-4dannjjm 6167 2 these these DT cord-023095-4dannjjm 6167 3 results result NNS cord-023095-4dannjjm 6167 4 suggest suggest VBP cord-023095-4dannjjm 6167 5 calcitriol calcitriol NN cord-023095-4dannjjm 6167 6 combination combination NN cord-023095-4dannjjm 6167 7 therapies therapy NNS cord-023095-4dannjjm 6167 8 might may MD cord-023095-4dannjjm 6167 9 have have VB cord-023095-4dannjjm 6167 10 significant significant JJ cord-023095-4dannjjm 6167 11 clinical clinical JJ cord-023095-4dannjjm 6167 12 utility utility NN cord-023095-4dannjjm 6167 13 in in IN cord-023095-4dannjjm 6167 14 the the DT cord-023095-4dannjjm 6167 15 treatment treatment NN cord-023095-4dannjjm 6167 16 of of IN cord-023095-4dannjjm 6167 17 canine canine JJ cord-023095-4dannjjm 6167 18 MCTs mct NNS cord-023095-4dannjjm 6167 19 but but CC cord-023095-4dannjjm 6167 20 refinement refinement NN cord-023095-4dannjjm 6167 21 of of IN cord-023095-4dannjjm 6167 22 the the DT cord-023095-4dannjjm 6167 23 calcitriol calcitriol NN cord-023095-4dannjjm 6167 24 - - HYPH cord-023095-4dannjjm 6167 25 dosing dose VBG cord-023095-4dannjjm 6167 26 regimen regimen NN cord-023095-4dannjjm 6167 27 must must MD cord-023095-4dannjjm 6167 28 be be VB cord-023095-4dannjjm 6167 29 done do VBN cord-023095-4dannjjm 6167 30 . . . cord-023095-4dannjjm 6168 1 Cyclosporine cyclosporine NN cord-023095-4dannjjm 6168 2 is be VBZ cord-023095-4dannjjm 6168 3 a a DT cord-023095-4dannjjm 6168 4 potent potent JJ cord-023095-4dannjjm 6168 5 immunosuppressive immunosuppressive JJ cord-023095-4dannjjm 6168 6 agent agent NN cord-023095-4dannjjm 6168 7 used use VBD cord-023095-4dannjjm 6168 8 to to TO cord-023095-4dannjjm 6168 9 treat treat VB cord-023095-4dannjjm 6168 10 many many JJ cord-023095-4dannjjm 6168 11 canine canine JJ cord-023095-4dannjjm 6168 12 inflammatory inflammatory JJ cord-023095-4dannjjm 6168 13 and and CC cord-023095-4dannjjm 6168 14 immune immune JJ cord-023095-4dannjjm 6168 15 - - HYPH cord-023095-4dannjjm 6168 16 mediated mediate VBN cord-023095-4dannjjm 6168 17 diseases disease NNS cord-023095-4dannjjm 6168 18 . . . cord-023095-4dannjjm 6169 1 Cyclosporine cyclosporine NN cord-023095-4dannjjm 6169 2 has have VBZ cord-023095-4dannjjm 6169 3 gained gain VBN cord-023095-4dannjjm 6169 4 popularity popularity NN cord-023095-4dannjjm 6169 5 as as IN cord-023095-4dannjjm 6169 6 an an DT cord-023095-4dannjjm 6169 7 immunosuppressive immunosuppressive JJ cord-023095-4dannjjm 6169 8 agent agent NN cord-023095-4dannjjm 6169 9 because because IN cord-023095-4dannjjm 6169 10 of of IN cord-023095-4dannjjm 6169 11 a a DT cord-023095-4dannjjm 6169 12 favorable favorable JJ cord-023095-4dannjjm 6169 13 toxicity toxicity NN cord-023095-4dannjjm 6169 14 profile profile NN cord-023095-4dannjjm 6169 15 compared compare VBN cord-023095-4dannjjm 6169 16 to to IN cord-023095-4dannjjm 6169 17 many many JJ cord-023095-4dannjjm 6169 18 other other JJ cord-023095-4dannjjm 6169 19 immunosuppressive immunosuppressive JJ cord-023095-4dannjjm 6169 20 agents agent NNS cord-023095-4dannjjm 6169 21 . . . cord-023095-4dannjjm 6170 1 Optimal optimal JJ cord-023095-4dannjjm 6170 2 dosing dosing NN cord-023095-4dannjjm 6170 3 regimens regimen NNS cord-023095-4dannjjm 6170 4 for for IN cord-023095-4dannjjm 6170 5 cyclosporine cyclosporine NN cord-023095-4dannjjm 6170 6 in in IN cord-023095-4dannjjm 6170 7 the the DT cord-023095-4dannjjm 6170 8 dog dog NN cord-023095-4dannjjm 6170 9 remain remain VBP cord-023095-4dannjjm 6170 10 unclear unclear JJ cord-023095-4dannjjm 6170 11 , , , cord-023095-4dannjjm 6170 12 primarily primarily RB cord-023095-4dannjjm 6170 13 because because IN cord-023095-4dannjjm 6170 14 standard standard JJ cord-023095-4dannjjm 6170 15 methods method NNS cord-023095-4dannjjm 6170 16 that that WDT cord-023095-4dannjjm 6170 17 monitor monitor VBP cord-023095-4dannjjm 6170 18 effectiveness effectiveness NN cord-023095-4dannjjm 6170 19 of of IN cord-023095-4dannjjm 6170 20 immunosuppression immunosuppression NN cord-023095-4dannjjm 6170 21 have have VBP cord-023095-4dannjjm 6170 22 not not RB cord-023095-4dannjjm 6170 23 been be VBN cord-023095-4dannjjm 6170 24 established establish VBN cord-023095-4dannjjm 6170 25 . . . cord-023095-4dannjjm 6171 1 Pharmacokinetic pharmacokinetic JJ cord-023095-4dannjjm 6171 2 testing testing NN cord-023095-4dannjjm 6171 3 is be VBZ cord-023095-4dannjjm 6171 4 currently currently RB cord-023095-4dannjjm 6171 5 used use VBN cord-023095-4dannjjm 6171 6 during during IN cord-023095-4dannjjm 6171 7 treatment treatment NN cord-023095-4dannjjm 6171 8 with with IN cord-023095-4dannjjm 6171 9 oral oral JJ cord-023095-4dannjjm 6171 10 cyclosporine cyclosporine NN cord-023095-4dannjjm 6171 11 to to TO cord-023095-4dannjjm 6171 12 adjust adjust VB cord-023095-4dannjjm 6171 13 doses dose NNS cord-023095-4dannjjm 6171 14 based base VBN cord-023095-4dannjjm 6171 15 on on IN cord-023095-4dannjjm 6171 16 measurement measurement NN cord-023095-4dannjjm 6171 17 of of IN cord-023095-4dannjjm 6171 18 blood blood NN cord-023095-4dannjjm 6171 19 drug drug NN cord-023095-4dannjjm 6171 20 levels level NNS cord-023095-4dannjjm 6171 21 . . . cord-023095-4dannjjm 6172 1 Individual individual JJ cord-023095-4dannjjm 6172 2 patients patient NNS cord-023095-4dannjjm 6172 3 , , , cord-023095-4dannjjm 6172 4 however however RB cord-023095-4dannjjm 6172 5 , , , cord-023095-4dannjjm 6172 6 often often RB cord-023095-4dannjjm 6172 7 demonstrate demonstrate VBP cord-023095-4dannjjm 6172 8 marked marked JJ cord-023095-4dannjjm 6172 9 variations variation NNS cord-023095-4dannjjm 6172 10 in in IN cord-023095-4dannjjm 6172 11 blood blood NN cord-023095-4dannjjm 6172 12 drug drug NN cord-023095-4dannjjm 6172 13 levels level NNS cord-023095-4dannjjm 6172 14 while while IN cord-023095-4dannjjm 6172 15 on on IN cord-023095-4dannjjm 6172 16 similar similar JJ cord-023095-4dannjjm 6172 17 oral oral JJ cord-023095-4dannjjm 6172 18 doses dose NNS cord-023095-4dannjjm 6172 19 of of IN cord-023095-4dannjjm 6172 20 cyclosporine cyclosporine NN cord-023095-4dannjjm 6172 21 , , , cord-023095-4dannjjm 6172 22 and and CC cord-023095-4dannjjm 6172 23 can can MD cord-023095-4dannjjm 6172 24 also also RB cord-023095-4dannjjm 6172 25 demonstrate demonstrate VB cord-023095-4dannjjm 6172 26 different different JJ cord-023095-4dannjjm 6172 27 clinical clinical JJ cord-023095-4dannjjm 6172 28 responses response NNS cord-023095-4dannjjm 6172 29 even even RB cord-023095-4dannjjm 6172 30 at at IN cord-023095-4dannjjm 6172 31 comparable comparable JJ cord-023095-4dannjjm 6172 32 drug drug NN cord-023095-4dannjjm 6172 33 levels level NNS cord-023095-4dannjjm 6172 34 , , , cord-023095-4dannjjm 6172 35 making make VBG cord-023095-4dannjjm 6172 36 correlation correlation NN cord-023095-4dannjjm 6172 37 of of IN cord-023095-4dannjjm 6172 38 blood blood NN cord-023095-4dannjjm 6172 39 cyclosporine cyclosporine NN cord-023095-4dannjjm 6172 40 levels level NNS cord-023095-4dannjjm 6172 41 and and CC cord-023095-4dannjjm 6172 42 degree degree NN cord-023095-4dannjjm 6172 43 of of IN cord-023095-4dannjjm 6172 44 disease disease NN cord-023095-4dannjjm 6172 45 control control NN cord-023095-4dannjjm 6172 46 extremely extremely RB cord-023095-4dannjjm 6172 47 difficult difficult JJ cord-023095-4dannjjm 6172 48 . . . cord-023095-4dannjjm 6173 1 Pharmacodynamic Pharmacodynamic NNP cord-023095-4dannjjm 6173 2 testing testing NN cord-023095-4dannjjm 6173 3 offers offer VBZ cord-023095-4dannjjm 6173 4 an an DT cord-023095-4dannjjm 6173 5 alternative alternative JJ cord-023095-4dannjjm 6173 6 method method NN cord-023095-4dannjjm 6173 7 for for IN cord-023095-4dannjjm 6173 8 regulating regulate VBG cord-023095-4dannjjm 6173 9 cyclosporine cyclosporine NN cord-023095-4dannjjm 6173 10 dosing dose VBG cord-023095-4dannjjm 6173 11 by by IN cord-023095-4dannjjm 6173 12 objectively objectively RB cord-023095-4dannjjm 6173 13 measuring measure VBG cord-023095-4dannjjm 6173 14 the the DT cord-023095-4dannjjm 6173 15 effects effect NNS cord-023095-4dannjjm 6173 16 of of IN cord-023095-4dannjjm 6173 17 cyclosporine cyclosporine NN cord-023095-4dannjjm 6173 18 on on IN cord-023095-4dannjjm 6173 19 T t NN cord-023095-4dannjjm 6173 20 - - HYPH cord-023095-4dannjjm 6173 21 cells cell NNS cord-023095-4dannjjm 6173 22 , , , cord-023095-4dannjjm 6173 23 the the DT cord-023095-4dannjjm 6173 24 drug drug NN cord-023095-4dannjjm 6173 25 's 's POS cord-023095-4dannjjm 6173 26 main main JJ cord-023095-4dannjjm 6173 27 cellular cellular JJ cord-023095-4dannjjm 6173 28 target target NN cord-023095-4dannjjm 6173 29 in in IN cord-023095-4dannjjm 6173 30 the the DT cord-023095-4dannjjm 6173 31 body body NN cord-023095-4dannjjm 6173 32 . . . cord-023095-4dannjjm 6174 1 Our -PRON- PRP$ cord-023095-4dannjjm 6174 2 ACVIM ACVIM NNP cord-023095-4dannjjm 6174 3 Foundation Foundation NNP cord-023095-4dannjjm 6174 4 - - HYPH cord-023095-4dannjjm 6174 5 funded fund VBN cord-023095-4dannjjm 6174 6 research research NN cord-023095-4dannjjm 6174 7 has have VBZ cord-023095-4dannjjm 6174 8 focused focus VBN cord-023095-4dannjjm 6174 9 on on IN cord-023095-4dannjjm 6174 10 developing develop VBG cord-023095-4dannjjm 6174 11 and and CC cord-023095-4dannjjm 6174 12 evaluating evaluate VBG cord-023095-4dannjjm 6174 13 a a DT cord-023095-4dannjjm 6174 14 comprehensive comprehensive JJ cord-023095-4dannjjm 6174 15 panel panel NN cord-023095-4dannjjm 6174 16 of of IN cord-023095-4dannjjm 6174 17 biomarkers biomarker NNS cord-023095-4dannjjm 6174 18 of of IN cord-023095-4dannjjm 6174 19 immunosuppression immunosuppression NN cord-023095-4dannjjm 6174 20 that that WDT cord-023095-4dannjjm 6174 21 can can MD cord-023095-4dannjjm 6174 22 be be VB cord-023095-4dannjjm 6174 23 utilized utilize VBN cord-023095-4dannjjm 6174 24 for for IN cord-023095-4dannjjm 6174 25 pharmacodynamic pharmacodynamic JJ cord-023095-4dannjjm 6174 26 monitoring monitoring NN cord-023095-4dannjjm 6174 27 during during IN cord-023095-4dannjjm 6174 28 treatment treatment NN cord-023095-4dannjjm 6174 29 with with IN cord-023095-4dannjjm 6174 30 cyclosporine cyclosporine NN cord-023095-4dannjjm 6174 31 and and CC cord-023095-4dannjjm 6174 32 other other JJ cord-023095-4dannjjm 6174 33 immunosuppressive immunosuppressive JJ cord-023095-4dannjjm 6174 34 agents agent NNS cord-023095-4dannjjm 6174 35 that that WDT cord-023095-4dannjjm 6174 36 affect affect VBP cord-023095-4dannjjm 6174 37 T t NN cord-023095-4dannjjm 6174 38 - - HYPH cord-023095-4dannjjm 6174 39 cell cell NN cord-023095-4dannjjm 6174 40 function function NN cord-023095-4dannjjm 6174 41 . . . cord-023095-4dannjjm 6175 1 We -PRON- PRP cord-023095-4dannjjm 6175 2 have have VBP cord-023095-4dannjjm 6175 3 completed complete VBN cord-023095-4dannjjm 6175 4 several several JJ cord-023095-4dannjjm 6175 5 studies study NNS cord-023095-4dannjjm 6175 6 using use VBG cord-023095-4dannjjm 6175 7 flow flow NN cord-023095-4dannjjm 6175 8 cytometry cytometry NN cord-023095-4dannjjm 6175 9 to to TO cord-023095-4dannjjm 6175 10 evaluate evaluate VB cord-023095-4dannjjm 6175 11 activated activate VBN cord-023095-4dannjjm 6175 12 T t NN cord-023095-4dannjjm 6175 13 - - HYPH cord-023095-4dannjjm 6175 14 cell cell NN cord-023095-4dannjjm 6175 15 expression expression NN cord-023095-4dannjjm 6175 16 of of IN cord-023095-4dannjjm 6175 17 surface surface NN cord-023095-4dannjjm 6175 18 molecules molecule NNS cord-023095-4dannjjm 6175 19 ( ( -LRB- cord-023095-4dannjjm 6175 20 CD25 CD25 NNP cord-023095-4dannjjm 6175 21 & & CC cord-023095-4dannjjm 6175 22 CD95 CD95 NNP cord-023095-4dannjjm 6175 23 ) ) -RRB- cord-023095-4dannjjm 6175 24 and and CC cord-023095-4dannjjm 6175 25 cytokines cytokine NNS cord-023095-4dannjjm 6175 26 ( ( -LRB- cord-023095-4dannjjm 6175 27 IL-2 IL-2 NNP cord-023095-4dannjjm 6175 28 , , , cord-023095-4dannjjm 6175 29 IFN IFN NNP cord-023095-4dannjjm 6175 30 - - HYPH cord-023095-4dannjjm 6175 31 g g NNP cord-023095-4dannjjm 6175 32 & & CC cord-023095-4dannjjm 6175 33 IL-4 IL-4 NNP cord-023095-4dannjjm 6175 34 ) ) -RRB- cord-023095-4dannjjm 6175 35 as as IN cord-023095-4dannjjm 6175 36 potential potential JJ cord-023095-4dannjjm 6175 37 biomarkers biomarker NNS cord-023095-4dannjjm 6175 38 . . . cord-023095-4dannjjm 6176 1 Our -PRON- PRP$ cord-023095-4dannjjm 6176 2 first first JJ cord-023095-4dannjjm 6176 3 study study NN cord-023095-4dannjjm 6176 4 was be VBD cord-023095-4dannjjm 6176 5 an an DT cord-023095-4dannjjm 6176 6 in in IN cord-023095-4dannjjm 6176 7 vitro vitro FW cord-023095-4dannjjm 6176 8 study study NN cord-023095-4dannjjm 6176 9 evaluating evaluate VBG cord-023095-4dannjjm 6176 10 expression expression NN cord-023095-4dannjjm 6176 11 of of IN cord-023095-4dannjjm 6176 12 surface surface NN cord-023095-4dannjjm 6176 13 molecules molecule NNS cord-023095-4dannjjm 6176 14 and and CC cord-023095-4dannjjm 6176 15 cytokines cytokine NNS cord-023095-4dannjjm 6176 16 in in IN cord-023095-4dannjjm 6176 17 canine canine JJ cord-023095-4dannjjm 6176 18 T t NN cord-023095-4dannjjm 6176 19 - - HYPH cord-023095-4dannjjm 6176 20 cells cell NNS cord-023095-4dannjjm 6176 21 exposed expose VBN cord-023095-4dannjjm 6176 22 to to IN cord-023095-4dannjjm 6176 23 varying vary VBG cord-023095-4dannjjm 6176 24 concentrations concentration NNS cord-023095-4dannjjm 6176 25 of of IN cord-023095-4dannjjm 6176 26 cyclosporine cyclosporine NN cord-023095-4dannjjm 6176 27 . . . cord-023095-4dannjjm 6177 1 This this DT cord-023095-4dannjjm 6177 2 study study NN cord-023095-4dannjjm 6177 3 established establish VBD cord-023095-4dannjjm 6177 4 consistent consistent JJ cord-023095-4dannjjm 6177 5 drug drug NN cord-023095-4dannjjm 6177 6 - - HYPH cord-023095-4dannjjm 6177 7 associated associate VBN cord-023095-4dannjjm 6177 8 suppression suppression NN cord-023095-4dannjjm 6177 9 of of IN cord-023095-4dannjjm 6177 10 the the DT cord-023095-4dannjjm 6177 11 cytokines cytokine NNS cord-023095-4dannjjm 6177 12 IL-2 IL-2 NNP cord-023095-4dannjjm 6177 13 , , , cord-023095-4dannjjm 6177 14 IFN IFN NNP cord-023095-4dannjjm 6177 15 - - HYPH cord-023095-4dannjjm 6177 16 g g NNP cord-023095-4dannjjm 6177 17 and and CC cord-023095-4dannjjm 6177 18 IL-4 IL-4 NNP cord-023095-4dannjjm 6177 19 . . . cord-023095-4dannjjm 6178 1 Our -PRON- PRP$ cord-023095-4dannjjm 6178 2 second second JJ cord-023095-4dannjjm 6178 3 study study NN cord-023095-4dannjjm 6178 4 was be VBD cord-023095-4dannjjm 6178 5 an an DT cord-023095-4dannjjm 6178 6 in in IN cord-023095-4dannjjm 6178 7 vivo vivo NN cord-023095-4dannjjm 6178 8 study study NN cord-023095-4dannjjm 6178 9 in in IN cord-023095-4dannjjm 6178 10 normal normal JJ cord-023095-4dannjjm 6178 11 dogs dog NNS cord-023095-4dannjjm 6178 12 evaluating evaluate VBG cord-023095-4dannjjm 6178 13 the the DT cord-023095-4dannjjm 6178 14 effects effect NNS cord-023095-4dannjjm 6178 15 of of IN cord-023095-4dannjjm 6178 16 two two CD cord-023095-4dannjjm 6178 17 doses dose NNS cord-023095-4dannjjm 6178 18 of of IN cord-023095-4dannjjm 6178 19 oral oral JJ cord-023095-4dannjjm 6178 20 cyclosporine cyclosporine NN cord-023095-4dannjjm 6178 21 , , , cord-023095-4dannjjm 6178 22 a a DT cord-023095-4dannjjm 6178 23 high high JJ cord-023095-4dannjjm 6178 24 dose dose NN cord-023095-4dannjjm 6178 25 considered consider VBN cord-023095-4dannjjm 6178 26 to to TO cord-023095-4dannjjm 6178 27 be be VB cord-023095-4dannjjm 6178 28 reliably reliably RB cord-023095-4dannjjm 6178 29 immunosuppressive immunosuppressive JJ cord-023095-4dannjjm 6178 30 ( ( -LRB- cord-023095-4dannjjm 6178 31 starting start VBG cord-023095-4dannjjm 6178 32 dose dose NN cord-023095-4dannjjm 6178 33 10 10 CD cord-023095-4dannjjm 6178 34 mg mg NNP cord-023095-4dannjjm 6178 35 / / SYM cord-023095-4dannjjm 6178 36 kg kg NN cord-023095-4dannjjm 6178 37 bid bid NN cord-023095-4dannjjm 6178 38 , , , cord-023095-4dannjjm 6178 39 titrated titrate VBN cord-023095-4dannjjm 6178 40 upwards upwards RB cord-023095-4dannjjm 6178 41 as as IN cord-023095-4dannjjm 6178 42 needed need VBN cord-023095-4dannjjm 6178 43 to to TO cord-023095-4dannjjm 6178 44 attain attain VB cord-023095-4dannjjm 6178 45 trough trough JJ cord-023095-4dannjjm 6178 46 drug drug NN cord-023095-4dannjjm 6178 47 blood blood NN cord-023095-4dannjjm 6178 48 levels level NNS cord-023095-4dannjjm 6178 49 of of IN cord-023095-4dannjjm 6178 50 at at RB cord-023095-4dannjjm 6178 51 least least JJS cord-023095-4dannjjm 6178 52 600 600 CD cord-023095-4dannjjm 6178 53 ng ng NN cord-023095-4dannjjm 6178 54 / / SYM cord-023095-4dannjjm 6178 55 mL mL NNP cord-023095-4dannjjm 6178 56 ) ) -RRB- cord-023095-4dannjjm 6178 57 and and CC cord-023095-4dannjjm 6178 58 a a DT cord-023095-4dannjjm 6178 59 lower low JJR cord-023095-4dannjjm 6178 60 dose dose NN cord-023095-4dannjjm 6178 61 used use VBN cord-023095-4dannjjm 6178 62 to to TO cord-023095-4dannjjm 6178 63 treat treat VB cord-023095-4dannjjm 6178 64 atopy atopy NN cord-023095-4dannjjm 6178 65 ( ( -LRB- cord-023095-4dannjjm 6178 66 5 5 CD cord-023095-4dannjjm 6178 67 mg mg NNP cord-023095-4dannjjm 6178 68 / / SYM cord-023095-4dannjjm 6178 69 kg kg NNP cord-023095-4dannjjm 6178 70 sid sid NNP cord-023095-4dannjjm 6178 71 ) ) -RRB- cord-023095-4dannjjm 6178 72 , , , cord-023095-4dannjjm 6178 73 on on IN cord-023095-4dannjjm 6178 74 T t NN cord-023095-4dannjjm 6178 75 - - HYPH cord-023095-4dannjjm 6178 76 cell cell NN cord-023095-4dannjjm 6178 77 expression expression NN cord-023095-4dannjjm 6178 78 of of IN cord-023095-4dannjjm 6178 79 these these DT cord-023095-4dannjjm 6178 80 three three CD cord-023095-4dannjjm 6178 81 cytokines cytokine NNS cord-023095-4dannjjm 6178 82 . . . cord-023095-4dannjjm 6179 1 Significant significant JJ cord-023095-4dannjjm 6179 2 suppression suppression NN cord-023095-4dannjjm 6179 3 of of IN cord-023095-4dannjjm 6179 4 IL-2 IL-2 NNP cord-023095-4dannjjm 6179 5 and and CC cord-023095-4dannjjm 6179 6 IFN IFN NNP cord-023095-4dannjjm 6179 7 - - HYPH cord-023095-4dannjjm 6179 8 g g NN cord-023095-4dannjjm 6179 9 expression expression NN cord-023095-4dannjjm 6179 10 was be VBD cord-023095-4dannjjm 6179 11 seen see VBN cord-023095-4dannjjm 6179 12 at at IN cord-023095-4dannjjm 6179 13 the the DT cord-023095-4dannjjm 6179 14 high high JJ cord-023095-4dannjjm 6179 15 cyclosporine cyclosporine NN cord-023095-4dannjjm 6179 16 dose dose NN cord-023095-4dannjjm 6179 17 , , , cord-023095-4dannjjm 6179 18 while while IN cord-023095-4dannjjm 6179 19 at at IN cord-023095-4dannjjm 6179 20 the the DT cord-023095-4dannjjm 6179 21 lower low JJR cord-023095-4dannjjm 6179 22 dose dose NN cord-023095-4dannjjm 6179 23 only only JJ cord-023095-4dannjjm 6179 24 IFN IFN NNP cord-023095-4dannjjm 6179 25 - - HYPH cord-023095-4dannjjm 6179 26 g g NN cord-023095-4dannjjm 6179 27 expression expression NN cord-023095-4dannjjm 6179 28 was be VBD cord-023095-4dannjjm 6179 29 suppressed suppress VBN cord-023095-4dannjjm 6179 30 . . . cord-023095-4dannjjm 6180 1 Because because IN cord-023095-4dannjjm 6180 2 Tcell Tcell NNP cord-023095-4dannjjm 6180 3 expression expression NN cord-023095-4dannjjm 6180 4 of of IN cord-023095-4dannjjm 6180 5 IL-4 IL-4 NNP cord-023095-4dannjjm 6180 6 was be VBD cord-023095-4dannjjm 6180 7 not not RB cord-023095-4dannjjm 6180 8 significantly significantly RB cord-023095-4dannjjm 6180 9 suppressed suppress VBN cord-023095-4dannjjm 6180 10 at at IN cord-023095-4dannjjm 6180 11 the the DT cord-023095-4dannjjm 6180 12 high high JJ cord-023095-4dannjjm 6180 13 cyclosporine cyclosporine NN cord-023095-4dannjjm 6180 14 dose dose NN cord-023095-4dannjjm 6180 15 , , , cord-023095-4dannjjm 6180 16 IL-4 IL-4 NNP cord-023095-4dannjjm 6180 17 was be VBD cord-023095-4dannjjm 6180 18 not not RB cord-023095-4dannjjm 6180 19 evaluated evaluate VBN cord-023095-4dannjjm 6180 20 at at IN cord-023095-4dannjjm 6180 21 the the DT cord-023095-4dannjjm 6180 22 lower low JJR cord-023095-4dannjjm 6180 23 drug drug NN cord-023095-4dannjjm 6180 24 dose dose NN cord-023095-4dannjjm 6180 25 . . . cord-023095-4dannjjm 6181 1 Because because IN cord-023095-4dannjjm 6181 2 of of IN cord-023095-4dannjjm 6181 3 specialized specialized JJ cord-023095-4dannjjm 6181 4 sample sample NN cord-023095-4dannjjm 6181 5 handling handling NN cord-023095-4dannjjm 6181 6 requirements requirement NNS cord-023095-4dannjjm 6181 7 , , , cord-023095-4dannjjm 6181 8 flow flow NN cord-023095-4dannjjm 6181 9 cytometry cytometry NN cord-023095-4dannjjm 6181 10 is be VBZ cord-023095-4dannjjm 6181 11 not not RB cord-023095-4dannjjm 6181 12 as as IN cord-023095-4dannjjm 6181 13 practitioner practitioner NN cord-023095-4dannjjm 6181 14 friendly friendly JJ cord-023095-4dannjjm 6181 15 as as IN cord-023095-4dannjjm 6181 16 other other JJ cord-023095-4dannjjm 6181 17 assays assay NNS cord-023095-4dannjjm 6181 18 ( ( -LRB- cord-023095-4dannjjm 6181 19 such such JJ cord-023095-4dannjjm 6181 20 as as IN cord-023095-4dannjjm 6181 21 PCR PCR NNP cord-023095-4dannjjm 6181 22 ) ) -RRB- cord-023095-4dannjjm 6181 23 for for IN cord-023095-4dannjjm 6181 24 routine routine JJ cord-023095-4dannjjm 6181 25 use use NN cord-023095-4dannjjm 6181 26 in in IN cord-023095-4dannjjm 6181 27 pharmacodynamic pharmacodynamic JJ cord-023095-4dannjjm 6181 28 testing testing NN cord-023095-4dannjjm 6181 29 . . . cord-023095-4dannjjm 6182 1 We -PRON- PRP cord-023095-4dannjjm 6182 2 have have VBP cord-023095-4dannjjm 6182 3 therefore therefore RB cord-023095-4dannjjm 6182 4 conducted conduct VBN cord-023095-4dannjjm 6182 5 an an DT cord-023095-4dannjjm 6182 6 in in IN cord-023095-4dannjjm 6182 7 vitro vitro FW cord-023095-4dannjjm 6182 8 study study NN cord-023095-4dannjjm 6182 9 comparing compare VBG cord-023095-4dannjjm 6182 10 the the DT cord-023095-4dannjjm 6182 11 effects effect NNS cord-023095-4dannjjm 6182 12 of of IN cord-023095-4dannjjm 6182 13 cyclosporine cyclosporine NN cord-023095-4dannjjm 6182 14 on on IN cord-023095-4dannjjm 6182 15 activated activate VBN cord-023095-4dannjjm 6182 16 T t NN cord-023095-4dannjjm 6182 17 - - HYPH cord-023095-4dannjjm 6182 18 cell cell NN cord-023095-4dannjjm 6182 19 expression expression NN cord-023095-4dannjjm 6182 20 of of IN cord-023095-4dannjjm 6182 21 IL-2 IL-2 NNP cord-023095-4dannjjm 6182 22 and and CC cord-023095-4dannjjm 6182 23 IFN IFN NNP cord-023095-4dannjjm 6182 24 - - HYPH cord-023095-4dannjjm 6182 25 g g NNP cord-023095-4dannjjm 6182 26 using use VBG cord-023095-4dannjjm 6182 27 flow flow NN cord-023095-4dannjjm 6182 28 cytometry cytometry NN cord-023095-4dannjjm 6182 29 and and CC cord-023095-4dannjjm 6182 30 qRT qRT NNP cord-023095-4dannjjm 6182 31 - - HYPH cord-023095-4dannjjm 6182 32 PCR PCR NNP cord-023095-4dannjjm 6182 33 , , , cord-023095-4dannjjm 6182 34 and and CC cord-023095-4dannjjm 6182 35 demonstrated demonstrate VBD cord-023095-4dannjjm 6182 36 dose dose NN cord-023095-4dannjjm 6182 37 dependent dependent JJ cord-023095-4dannjjm 6182 38 and and CC cord-023095-4dannjjm 6182 39 comparable comparable JJ cord-023095-4dannjjm 6182 40 suppression suppression NN cord-023095-4dannjjm 6182 41 of of IN cord-023095-4dannjjm 6182 42 IL-2 IL-2 NNP cord-023095-4dannjjm 6182 43 and and CC cord-023095-4dannjjm 6182 44 IFN IFN NNP cord-023095-4dannjjm 6182 45 - - HYPH cord-023095-4dannjjm 6182 46 g g NNP cord-023095-4dannjjm 6182 47 using use VBG cord-023095-4dannjjm 6182 48 either either CC cord-023095-4dannjjm 6182 49 methodology methodology NN cord-023095-4dannjjm 6182 50 . . . cord-023095-4dannjjm 6183 1 We -PRON- PRP cord-023095-4dannjjm 6183 2 are be VBP cord-023095-4dannjjm 6183 3 currently currently RB cord-023095-4dannjjm 6183 4 evaluating evaluate VBG cord-023095-4dannjjm 6183 5 , , , cord-023095-4dannjjm 6183 6 using use VBG cord-023095-4dannjjm 6183 7 qRT qrt ADD cord-023095-4dannjjm 6183 8 - - HYPH cord-023095-4dannjjm 6183 9 PCR PCR NNP cord-023095-4dannjjm 6183 10 , , , cord-023095-4dannjjm 6183 11 the the DT cord-023095-4dannjjm 6183 12 effects effect NNS cord-023095-4dannjjm 6183 13 of of IN cord-023095-4dannjjm 6183 14 oral oral JJ cord-023095-4dannjjm 6183 15 cyclosporine cyclosporine NN cord-023095-4dannjjm 6183 16 on on IN cord-023095-4dannjjm 6183 17 T t NN cord-023095-4dannjjm 6183 18 - - HYPH cord-023095-4dannjjm 6183 19 cell cell NN cord-023095-4dannjjm 6183 20 expression expression NN cord-023095-4dannjjm 6183 21 of of IN cord-023095-4dannjjm 6183 22 IL-2 IL-2 NNP cord-023095-4dannjjm 6183 23 and and CC cord-023095-4dannjjm 6183 24 IFN IFN NNP cord-023095-4dannjjm 6183 25 - - HYPH cord-023095-4dannjjm 6183 26 g g NNP cord-023095-4dannjjm 6183 27 in in IN cord-023095-4dannjjm 6183 28 normal normal JJ cord-023095-4dannjjm 6183 29 dogs dog NNS cord-023095-4dannjjm 6183 30 prior prior RB cord-023095-4dannjjm 6183 31 to to IN cord-023095-4dannjjm 6183 32 moving move VBG cord-023095-4dannjjm 6183 33 on on RP cord-023095-4dannjjm 6183 34 to to IN cord-023095-4dannjjm 6183 35 pharmacodynamic pharmacodynamic JJ cord-023095-4dannjjm 6183 36 trials trial NNS cord-023095-4dannjjm 6183 37 in in IN cord-023095-4dannjjm 6183 38 our -PRON- PRP$ cord-023095-4dannjjm 6183 39 clinic clinic NN cord-023095-4dannjjm 6183 40 patients patient NNS cord-023095-4dannjjm 6183 41 . . . cord-023095-4dannjjm 6184 1 EFFECT effect NN cord-023095-4dannjjm 6184 2 OF of IN cord-023095-4dannjjm 6184 3 HYPOTHYROIDISM hypothyroidism NN cord-023095-4dannjjm 6184 4 ON on IN cord-023095-4dannjjm 6184 5 REPRODUCTION reproduction NN cord-023095-4dannjjm 6184 6 IN in IN cord-023095-4dannjjm 6184 7 BITCHES bitch NNS cord-023095-4dannjjm 6184 8 . . . cord-023095-4dannjjm 6185 1 DL DL NNP cord-023095-4dannjjm 6185 2 Panciera Panciera NNP cord-023095-4dannjjm 6185 3 1 1 CD cord-023095-4dannjjm 6185 4 , , , cord-023095-4dannjjm 6185 5 BJ BJ NNP cord-023095-4dannjjm 6185 6 Purswell Purswell NNP cord-023095-4dannjjm 6185 7 2 2 CD cord-023095-4dannjjm 6185 8 , , , cord-023095-4dannjjm 6185 9 KA KA NNP cord-023095-4dannjjm 6185 10 Kolster Kolster NNP cord-023095-4dannjjm 6185 11 2 2 CD cord-023095-4dannjjm 6185 12 , , , cord-023095-4dannjjm 6185 13 SR SR NNP cord-023095-4dannjjm 6185 14 Werre Werre NNP cord-023095-4dannjjm 6185 15 3 3 CD cord-023095-4dannjjm 6185 16 . . . cord-023095-4dannjjm 6186 1 Departments department NNS cord-023095-4dannjjm 6186 2 of of IN cord-023095-4dannjjm 6186 3 1 1 CD cord-023095-4dannjjm 6186 4 Small Small NNP cord-023095-4dannjjm 6186 5 Animal Animal NNP cord-023095-4dannjjm 6186 6 Clinical Clinical NNP cord-023095-4dannjjm 6186 7 Sciences Sciences NNPS cord-023095-4dannjjm 6186 8 , , , cord-023095-4dannjjm 6186 9 2 2 CD cord-023095-4dannjjm 6186 10 Large Large NNP cord-023095-4dannjjm 6186 11 Animal Animal NNP cord-023095-4dannjjm 6186 12 Clinical Clinical NNP cord-023095-4dannjjm 6186 13 Sciences Sciences NNPS cord-023095-4dannjjm 6186 14 , , , cord-023095-4dannjjm 6186 15 and and CC cord-023095-4dannjjm 6186 16 3 3 CD cord-023095-4dannjjm 6186 17 Laboratory Laboratory NNP cord-023095-4dannjjm 6186 18 for for IN cord-023095-4dannjjm 6186 19 Study Study NNP cord-023095-4dannjjm 6186 20 Design Design NNP cord-023095-4dannjjm 6186 21 and and CC cord-023095-4dannjjm 6186 22 Data Data NNP cord-023095-4dannjjm 6186 23 Analysis Analysis NNP cord-023095-4dannjjm 6186 24 , , , cord-023095-4dannjjm 6186 25 Virginia Virginia NNP cord-023095-4dannjjm 6186 26 - - HYPH cord-023095-4dannjjm 6186 27 Maryland Maryland NNP cord-023095-4dannjjm 6186 28 Regional Regional NNP cord-023095-4dannjjm 6186 29 College College NNP cord-023095-4dannjjm 6186 30 of of IN cord-023095-4dannjjm 6186 31 Veterinary Veterinary NNP cord-023095-4dannjjm 6186 32 Medicine Medicine NNP cord-023095-4dannjjm 6186 33 , , , cord-023095-4dannjjm 6186 34 Virginia Virginia NNP cord-023095-4dannjjm 6186 35 Tech Tech NNP cord-023095-4dannjjm 6186 36 , , , cord-023095-4dannjjm 6186 37 Blacksburg Blacksburg NNP cord-023095-4dannjjm 6186 38 , , , cord-023095-4dannjjm 6186 39 VA VA NNP cord-023095-4dannjjm 6186 40 . . . cord-023095-4dannjjm 6187 1 Numerous numerous JJ cord-023095-4dannjjm 6187 2 reproductive reproductive JJ cord-023095-4dannjjm 6187 3 abnormalities abnormality NNS cord-023095-4dannjjm 6187 4 , , , cord-023095-4dannjjm 6187 5 including include VBG cord-023095-4dannjjm 6187 6 irregular irregular JJ cord-023095-4dannjjm 6187 7 interestrous interestrous JJ cord-023095-4dannjjm 6187 8 period period NN cord-023095-4dannjjm 6187 9 , , , cord-023095-4dannjjm 6187 10 anestrus anestrus NNP cord-023095-4dannjjm 6187 11 , , , cord-023095-4dannjjm 6187 12 and and CC cord-023095-4dannjjm 6187 13 infertility infertility NN cord-023095-4dannjjm 6187 14 have have VBP cord-023095-4dannjjm 6187 15 been be VBN cord-023095-4dannjjm 6187 16 attributed attribute VBN cord-023095-4dannjjm 6187 17 to to IN cord-023095-4dannjjm 6187 18 hypothyroidism hypothyroidism NN cord-023095-4dannjjm 6187 19 . . . cord-023095-4dannjjm 6188 1 We -PRON- PRP cord-023095-4dannjjm 6188 2 previously previously RB cord-023095-4dannjjm 6188 3 documented document VBD cord-023095-4dannjjm 6188 4 reduced reduced JJ cord-023095-4dannjjm 6188 5 fertility fertility NN cord-023095-4dannjjm 6188 6 and and CC cord-023095-4dannjjm 6188 7 lower low JJR cord-023095-4dannjjm 6188 8 birth birth NN cord-023095-4dannjjm 6188 9 weight weight NN cord-023095-4dannjjm 6188 10 and and CC cord-023095-4dannjjm 6188 11 increased increase VBN cord-023095-4dannjjm 6188 12 periparturient periparturient NN cord-023095-4dannjjm 6188 13 mortality mortality NN cord-023095-4dannjjm 6188 14 in in IN cord-023095-4dannjjm 6188 15 pups pup NNS cord-023095-4dannjjm 6188 16 born bear VBN cord-023095-4dannjjm 6188 17 to to IN cord-023095-4dannjjm 6188 18 bitches bitch NNS cord-023095-4dannjjm 6188 19 with with IN cord-023095-4dannjjm 6188 20 experimentally experimentally RB cord-023095-4dannjjm 6188 21 - - HYPH cord-023095-4dannjjm 6188 22 induced induce VBN cord-023095-4dannjjm 6188 23 hypothyroidism hypothyroidism NN cord-023095-4dannjjm 6188 24 for for IN cord-023095-4dannjjm 6188 25 a a DT cord-023095-4dannjjm 6188 26 median median JJ cord-023095-4dannjjm 6188 27 duration duration NN cord-023095-4dannjjm 6188 28 of of IN cord-023095-4dannjjm 6188 29 56 56 CD cord-023095-4dannjjm 6188 30 weeks week NNS cord-023095-4dannjjm 6188 31 . . . cord-023095-4dannjjm 6189 1 The the DT cord-023095-4dannjjm 6189 2 purpose purpose NN cord-023095-4dannjjm 6189 3 of of IN cord-023095-4dannjjm 6189 4 this this DT cord-023095-4dannjjm 6189 5 study study NN cord-023095-4dannjjm 6189 6 was be VBD cord-023095-4dannjjm 6189 7 to to TO cord-023095-4dannjjm 6189 8 evaluate evaluate VB cord-023095-4dannjjm 6189 9 reproductive reproductive JJ cord-023095-4dannjjm 6189 10 function function NN cord-023095-4dannjjm 6189 11 in in IN cord-023095-4dannjjm 6189 12 these these DT cord-023095-4dannjjm 6189 13 same same JJ cord-023095-4dannjjm 6189 14 bitches bitch NNS cord-023095-4dannjjm 6189 15 after after IN cord-023095-4dannjjm 6189 16 hypothyroidism hypothyroidism NN cord-023095-4dannjjm 6189 17 was be VBD cord-023095-4dannjjm 6189 18 treated treat VBN cord-023095-4dannjjm 6189 19 with with IN cord-023095-4dannjjm 6189 20 a a DT cord-023095-4dannjjm 6189 21 replacement replacement NN cord-023095-4dannjjm 6189 22 dose dose NN cord-023095-4dannjjm 6189 23 of of IN cord-023095-4dannjjm 6189 24 levothyroxine levothyroxine NN cord-023095-4dannjjm 6189 25 . . . cord-023095-4dannjjm 6190 1 Twelve twelve CD cord-023095-4dannjjm 6190 2 multiparous multiparous JJ cord-023095-4dannjjm 6190 3 bitches bitch NNS cord-023095-4dannjjm 6190 4 were be VBD cord-023095-4dannjjm 6190 5 studied study VBN cord-023095-4dannjjm 6190 6 . . . cord-023095-4dannjjm 6191 1 Hypothyroidism hypothyroidism NN cord-023095-4dannjjm 6191 2 was be VBD cord-023095-4dannjjm 6191 3 induced induce VBN cord-023095-4dannjjm 6191 4 in in IN cord-023095-4dannjjm 6191 5 6 6 CD cord-023095-4dannjjm 6191 6 dogs dog NNS cord-023095-4dannjjm 6191 7 by by IN cord-023095-4dannjjm 6191 8 administration administration NN cord-023095-4dannjjm 6191 9 of of IN cord-023095-4dannjjm 6191 10 1 1 CD cord-023095-4dannjjm 6191 11 mCi mCi NNPS cord-023095-4dannjjm 6191 12 / / SYM cord-023095-4dannjjm 6191 13 kg kg NN cord-023095-4dannjjm 6191 14 131 131 CD cord-023095-4dannjjm 6191 15 I. i. NN cord-023095-4dannjjm 6191 16 Hypothyroidism hypothyroidism NN cord-023095-4dannjjm 6191 17 was be VBD cord-023095-4dannjjm 6191 18 confirmed confirm VBN cord-023095-4dannjjm 6191 19 by by IN cord-023095-4dannjjm 6191 20 finding find VBG cord-023095-4dannjjm 6191 21 serum serum NN cord-023095-4dannjjm 6191 22 T4 T4 NNP cord-023095-4dannjjm 6191 23 concentrations concentration NNS cord-023095-4dannjjm 6191 24 before before IN cord-023095-4dannjjm 6191 25 and and CC cord-023095-4dannjjm 6191 26 4 4 CD cord-023095-4dannjjm 6191 27 hours hour NNS cord-023095-4dannjjm 6191 28 after after IN cord-023095-4dannjjm 6191 29 IV IV NNP cord-023095-4dannjjm 6191 30 administration administration NN cord-023095-4dannjjm 6191 31 of of IN cord-023095-4dannjjm 6191 32 human human JJ cord-023095-4dannjjm 6191 33 recombinant recombinant JJ cord-023095-4dannjjm 6191 34 TSH TSH NNP cord-023095-4dannjjm 6191 35 that that WDT cord-023095-4dannjjm 6191 36 were be VBD cord-023095-4dannjjm 6191 37 o o NN cord-023095-4dannjjm 6191 38 5 5 CD cord-023095-4dannjjm 6191 39 nmol nmol NNP cord-023095-4dannjjm 6191 40 / / SYM cord-023095-4dannjjm 6191 41 L. L. NNP cord-023095-4dannjjm 6191 42 Levothyroxine Levothyroxine NNP cord-023095-4dannjjm 6191 43 ( ( -LRB- cord-023095-4dannjjm 6192 1 0.02 0.02 CD cord-023095-4dannjjm 6192 2 mg mg NNP cord-023095-4dannjjm 6192 3 / / SYM cord-023095-4dannjjm 6192 4 kd kd NNP cord-023095-4dannjjm 6192 5 q q NNP cord-023095-4dannjjm 6192 6 24 24 CD cord-023095-4dannjjm 6192 7 h h NNP cord-023095-4dannjjm 6192 8 ) ) -RRB- cord-023095-4dannjjm 6192 9 was be VBD cord-023095-4dannjjm 6192 10 administered administer VBN cord-023095-4dannjjm 6192 11 to to IN cord-023095-4dannjjm 6192 12 all all DT cord-023095-4dannjjm 6192 13 hypothyroid hypothyroid JJ cord-023095-4dannjjm 6192 14 bitches bitch NNS cord-023095-4dannjjm 6192 15 . . . cord-023095-4dannjjm 6193 1 Six six CD cord-023095-4dannjjm 6193 2 bitches bitch NNS cord-023095-4dannjjm 6193 3 served serve VBD cord-023095-4dannjjm 6193 4 as as IN cord-023095-4dannjjm 6193 5 euthyroid euthyroid NNP cord-023095-4dannjjm 6193 6 , , , cord-023095-4dannjjm 6193 7 untreated untreated JJ cord-023095-4dannjjm 6193 8 controls control NNS cord-023095-4dannjjm 6193 9 . . . cord-023095-4dannjjm 6194 1 Dogs dog NNS cord-023095-4dannjjm 6194 2 were be VBD cord-023095-4dannjjm 6194 3 evaluated evaluate VBN cord-023095-4dannjjm 6194 4 daily daily RB cord-023095-4dannjjm 6194 5 for for IN cord-023095-4dannjjm 6194 6 signs sign NNS cord-023095-4dannjjm 6194 7 of of IN cord-023095-4dannjjm 6194 8 estrus estrus NN cord-023095-4dannjjm 6194 9 and and CC cord-023095-4dannjjm 6194 10 were be VBD cord-023095-4dannjjm 6194 11 bred breed VBN cord-023095-4dannjjm 6194 12 by by IN cord-023095-4dannjjm 6194 13 1 1 CD cord-023095-4dannjjm 6194 14 of of IN cord-023095-4dannjjm 6194 15 2 2 CD cord-023095-4dannjjm 6194 16 males male NNS cord-023095-4dannjjm 6194 17 when when WRB cord-023095-4dannjjm 6194 18 serum serum NN cord-023095-4dannjjm 6194 19 progesterone progesterone NN cord-023095-4dannjjm 6194 20 was be VBD cord-023095-4dannjjm 6194 21 ! ! . cord-023095-4dannjjm 6195 1 5 5 LS cord-023095-4dannjjm 6196 1 ng ng NNP cord-023095-4dannjjm 6196 2 / / SYM cord-023095-4dannjjm 6196 3 ml ml NN cord-023095-4dannjjm 6196 4 . . . cord-023095-4dannjjm 6197 1 Interestrous interestrous JJ cord-023095-4dannjjm 6197 2 interval interval NN cord-023095-4dannjjm 6197 3 , , , cord-023095-4dannjjm 6197 4 gestation gestation NN cord-023095-4dannjjm 6197 5 length length NN cord-023095-4dannjjm 6197 6 , , , cord-023095-4dannjjm 6197 7 strength strength NN cord-023095-4dannjjm 6197 8 and and CC cord-023095-4dannjjm 6197 9 duration duration NN cord-023095-4dannjjm 6197 10 of of IN cord-023095-4dannjjm 6197 11 contractions contraction NNS cord-023095-4dannjjm 6197 12 during during IN cord-023095-4dannjjm 6197 13 whelping whelping NN cord-023095-4dannjjm 6197 14 , , , cord-023095-4dannjjm 6197 15 time time NN cord-023095-4dannjjm 6197 16 between between IN cord-023095-4dannjjm 6197 17 pups pup NNS cord-023095-4dannjjm 6197 18 , , , cord-023095-4dannjjm 6197 19 number number NN cord-023095-4dannjjm 6197 20 of of IN cord-023095-4dannjjm 6197 21 live live JJ cord-023095-4dannjjm 6197 22 pups pup NNS cord-023095-4dannjjm 6197 23 and and CC cord-023095-4dannjjm 6197 24 stillbirths stillbirth NNS cord-023095-4dannjjm 6197 25 , , , cord-023095-4dannjjm 6197 26 viability viability NN cord-023095-4dannjjm 6197 27 of of IN cord-023095-4dannjjm 6197 28 pups pup NNS cord-023095-4dannjjm 6197 29 at at IN cord-023095-4dannjjm 6197 30 birth birth NN cord-023095-4dannjjm 6197 31 , , , cord-023095-4dannjjm 6197 32 weight weight NN cord-023095-4dannjjm 6197 33 of of IN cord-023095-4dannjjm 6197 34 pups pup NNS cord-023095-4dannjjm 6197 35 , , , cord-023095-4dannjjm 6197 36 and and CC cord-023095-4dannjjm 6197 37 periparturient periparturient NN cord-023095-4dannjjm 6197 38 mortality mortality NN cord-023095-4dannjjm 6197 39 were be VBD cord-023095-4dannjjm 6197 40 recorded record VBN cord-023095-4dannjjm 6197 41 . . . cord-023095-4dannjjm 6198 1 The the DT cord-023095-4dannjjm 6198 2 Student Student NNP cord-023095-4dannjjm 6198 3 's 's POS cord-023095-4dannjjm 6198 4 t t NN cord-023095-4dannjjm 6198 5 - - HYPH cord-023095-4dannjjm 6198 6 test test NN cord-023095-4dannjjm 6198 7 and and CC cord-023095-4dannjjm 6198 8 ANOVA ANOVA NNP cord-023095-4dannjjm 6198 9 were be VBD cord-023095-4dannjjm 6198 10 used use VBN cord-023095-4dannjjm 6198 11 to to TO cord-023095-4dannjjm 6198 12 compare compare VB cord-023095-4dannjjm 6198 13 differences difference NNS cord-023095-4dannjjm 6198 14 between between IN cord-023095-4dannjjm 6198 15 control control NN cord-023095-4dannjjm 6198 16 and and CC cord-023095-4dannjjm 6198 17 hypothyroid hypothyroid JJ cord-023095-4dannjjm 6198 18 bitches bitch NNS cord-023095-4dannjjm 6198 19 for for IN cord-023095-4dannjjm 6198 20 continuous continuous JJ cord-023095-4dannjjm 6198 21 , , , cord-023095-4dannjjm 6198 22 normally normally RB cord-023095-4dannjjm 6198 23 distributed distribute VBN cord-023095-4dannjjm 6198 24 data datum NNS cord-023095-4dannjjm 6198 25 . . . cord-023095-4dannjjm 6199 1 The the DT cord-023095-4dannjjm 6199 2 Wilcoxon Wilcoxon NNP cord-023095-4dannjjm 6199 3 rank rank NN cord-023095-4dannjjm 6199 4 sum sum NN cord-023095-4dannjjm 6199 5 test test NN cord-023095-4dannjjm 6199 6 was be VBD cord-023095-4dannjjm 6199 7 used use VBN cord-023095-4dannjjm 6199 8 to to TO cord-023095-4dannjjm 6199 9 analyze analyze VB cord-023095-4dannjjm 6199 10 data datum NNS cord-023095-4dannjjm 6199 11 between between IN cord-023095-4dannjjm 6199 12 groups group NNS cord-023095-4dannjjm 6199 13 that that WDT cord-023095-4dannjjm 6199 14 was be VBD cord-023095-4dannjjm 6199 15 not not RB cord-023095-4dannjjm 6199 16 normally normally RB cord-023095-4dannjjm 6199 17 distributed distribute VBN cord-023095-4dannjjm 6199 18 . . . cord-023095-4dannjjm 6200 1 The the DT cord-023095-4dannjjm 6200 2 mean mean JJ cord-023095-4dannjjm 6200 3 duration duration NN cord-023095-4dannjjm 6200 4 of of IN cord-023095-4dannjjm 6200 5 hypothyroidism hypothyroidism NN cord-023095-4dannjjm 6200 6 prior prior RB cord-023095-4dannjjm 6200 7 to to IN cord-023095-4dannjjm 6200 8 levothyroxine levothyroxine NNP cord-023095-4dannjjm 6200 9 administration administration NNP cord-023095-4dannjjm 6200 10 was be VBD cord-023095-4dannjjm 6200 11 102 102 CD cord-023095-4dannjjm 6200 12 AE AE NNP cord-023095-4dannjjm 6200 13 8.1 8.1 CD cord-023095-4dannjjm 6200 14 weeks week NNS cord-023095-4dannjjm 6200 15 . . . cord-023095-4dannjjm 6201 1 Breeding breeding NN cord-023095-4dannjjm 6201 2 took take VBD cord-023095-4dannjjm 6201 3 place place NN cord-023095-4dannjjm 6201 4 after after IN cord-023095-4dannjjm 6201 5 levothyroxine levothyroxine NN cord-023095-4dannjjm 6201 6 treatment treatment NN cord-023095-4dannjjm 6201 7 for for IN cord-023095-4dannjjm 6201 8 46 46 CD cord-023095-4dannjjm 6201 9 AE AE NNP cord-023095-4dannjjm 6201 10 12.6 12.6 CD cord-023095-4dannjjm 6201 11 weeks week NNS cord-023095-4dannjjm 6201 12 in in IN cord-023095-4dannjjm 6201 13 the the DT cord-023095-4dannjjm 6201 14 hypothyroid hypothyroid JJ cord-023095-4dannjjm 6201 15 group group NN cord-023095-4dannjjm 6201 16 . . . cord-023095-4dannjjm 6202 1 All all DT cord-023095-4dannjjm 6202 2 6 6 CD cord-023095-4dannjjm 6202 3 dogs dog NNS cord-023095-4dannjjm 6202 4 in in IN cord-023095-4dannjjm 6202 5 the the DT cord-023095-4dannjjm 6202 6 hypothyroid hypothyroid JJ cord-023095-4dannjjm 6202 7 group group NN cord-023095-4dannjjm 6202 8 and and CC cord-023095-4dannjjm 6202 9 5/6 5/6 CD cord-023095-4dannjjm 6202 10 control control NN cord-023095-4dannjjm 6202 11 dogs dog NNS cord-023095-4dannjjm 6202 12 were be VBD cord-023095-4dannjjm 6202 13 pregnant pregnant JJ cord-023095-4dannjjm 6202 14 , , , cord-023095-4dannjjm 6202 15 while while IN cord-023095-4dannjjm 6202 16 4/8 4/8 CD cord-023095-4dannjjm 6202 17 hypothyroid hypothyroid NN cord-023095-4dannjjm 6202 18 and and CC cord-023095-4dannjjm 6202 19 all all DT cord-023095-4dannjjm 6202 20 6 6 CD cord-023095-4dannjjm 6202 21 control control NN cord-023095-4dannjjm 6202 22 bitches bitch NNS cord-023095-4dannjjm 6202 23 became become VBD cord-023095-4dannjjm 6202 24 pregnant pregnant JJ cord-023095-4dannjjm 6202 25 prior prior RB cord-023095-4dannjjm 6202 26 to to IN cord-023095-4dannjjm 6202 27 levothyroxine levothyroxine NNP cord-023095-4dannjjm 6202 28 administration administration NNP cord-023095-4dannjjm 6202 29 . . . cord-023095-4dannjjm 6203 1 No no DT cord-023095-4dannjjm 6203 2 difference difference NN cord-023095-4dannjjm 6203 3 in in IN cord-023095-4dannjjm 6203 4 interestrus interestrus NNP cord-023095-4dannjjm 6203 5 interval interval NN cord-023095-4dannjjm 6203 6 or or CC cord-023095-4dannjjm 6203 7 gestation gestation NN cord-023095-4dannjjm 6203 8 length length NN cord-023095-4dannjjm 6203 9 was be VBD cord-023095-4dannjjm 6203 10 noted note VBN cord-023095-4dannjjm 6203 11 between between IN cord-023095-4dannjjm 6203 12 groups group NNS cord-023095-4dannjjm 6203 13 . . . cord-023095-4dannjjm 6204 1 During during IN cord-023095-4dannjjm 6204 2 whelping whelping NN cord-023095-4dannjjm 6204 3 , , , cord-023095-4dannjjm 6204 4 no no DT cord-023095-4dannjjm 6204 5 difference difference NN cord-023095-4dannjjm 6204 6 in in IN cord-023095-4dannjjm 6204 7 strength strength NN cord-023095-4dannjjm 6204 8 of of IN cord-023095-4dannjjm 6204 9 contractions contraction NNS cord-023095-4dannjjm 6204 10 , , , cord-023095-4dannjjm 6204 11 contraction contraction NN cord-023095-4dannjjm 6204 12 duration duration NN cord-023095-4dannjjm 6204 13 , , , cord-023095-4dannjjm 6204 14 interval interval NN cord-023095-4dannjjm 6204 15 between between IN cord-023095-4dannjjm 6204 16 pups pup NNS cord-023095-4dannjjm 6204 17 , , , cord-023095-4dannjjm 6204 18 or or CC cord-023095-4dannjjm 6204 19 viability viability NN cord-023095-4dannjjm 6204 20 scores score NNS cord-023095-4dannjjm 6204 21 of of IN cord-023095-4dannjjm 6204 22 pups pup NNS cord-023095-4dannjjm 6204 23 was be VBD cord-023095-4dannjjm 6204 24 found find VBN cord-023095-4dannjjm 6204 25 between between IN cord-023095-4dannjjm 6204 26 groups group NNS cord-023095-4dannjjm 6204 27 . . . cord-023095-4dannjjm 6205 1 Litter litter NN cord-023095-4dannjjm 6205 2 size size NN cord-023095-4dannjjm 6205 3 , , , cord-023095-4dannjjm 6205 4 birth birth NN cord-023095-4dannjjm 6205 5 weight weight NN cord-023095-4dannjjm 6205 6 and and CC cord-023095-4dannjjm 6205 7 peirparturient peirparturient JJ cord-023095-4dannjjm 6205 8 mortality mortality NN cord-023095-4dannjjm 6205 9 were be VBD cord-023095-4dannjjm 6205 10 similar similar JJ cord-023095-4dannjjm 6205 11 between between IN cord-023095-4dannjjm 6205 12 groups group NNS cord-023095-4dannjjm 6205 13 . . . cord-023095-4dannjjm 6206 1 Levothyroxine Levothyroxine NNP cord-023095-4dannjjm 6206 2 administration administration NN cord-023095-4dannjjm 6206 3 reverses reverse VBZ cord-023095-4dannjjm 6206 4 the the DT cord-023095-4dannjjm 6206 5 detrimental detrimental JJ cord-023095-4dannjjm 6206 6 effects effect NNS cord-023095-4dannjjm 6206 7 of of IN cord-023095-4dannjjm 6206 8 hypothyroidism hypothyroidism NN cord-023095-4dannjjm 6206 9 on on IN cord-023095-4dannjjm 6206 10 fertility fertility NN cord-023095-4dannjjm 6206 11 and and CC cord-023095-4dannjjm 6206 12 neonatal neonatal JJ cord-023095-4dannjjm 6206 13 health health NN cord-023095-4dannjjm 6206 14 . . . cord-023095-4dannjjm 6207 1 Racing race VBG cord-023095-4dannjjm 6207 2 sled sled JJ cord-023095-4dannjjm 6207 3 dogs dog NNS cord-023095-4dannjjm 6207 4 have have VBP cord-023095-4dannjjm 6207 5 a a DT cord-023095-4dannjjm 6207 6 high high JJ cord-023095-4dannjjm 6207 7 prevalence prevalence NN cord-023095-4dannjjm 6207 8 of of IN cord-023095-4dannjjm 6207 9 exercise exercise NN cord-023095-4dannjjm 6207 10 - - HYPH cord-023095-4dannjjm 6207 11 induced induce VBN cord-023095-4dannjjm 6207 12 gastric gastric JJ cord-023095-4dannjjm 6207 13 erosions erosion NNS cord-023095-4dannjjm 6207 14 / / SYM cord-023095-4dannjjm 6207 15 ulcers ulcer NNS cord-023095-4dannjjm 6207 16 , , , cord-023095-4dannjjm 6207 17 with with IN cord-023095-4dannjjm 6207 18 reports report NNS cord-023095-4dannjjm 6207 19 ranging range VBG cord-023095-4dannjjm 6207 20 from from IN cord-023095-4dannjjm 6207 21 50 50 CD cord-023095-4dannjjm 6207 22 - - SYM cord-023095-4dannjjm 6207 23 67 67 CD cord-023095-4dannjjm 6207 24 % % NN cord-023095-4dannjjm 6207 25 of of IN cord-023095-4dannjjm 6207 26 dogs dog NNS cord-023095-4dannjjm 6207 27 running run VBG cord-023095-4dannjjm 6207 28 at at RB cord-023095-4dannjjm 6207 29 least least RBS cord-023095-4dannjjm 6207 30 100 100 CD cord-023095-4dannjjm 6207 31 miles mile NNS cord-023095-4dannjjm 6207 32 in in IN cord-023095-4dannjjm 6207 33 a a DT cord-023095-4dannjjm 6207 34 day day NN cord-023095-4dannjjm 6207 35 or or CC cord-023095-4dannjjm 6207 36 less less JJR cord-023095-4dannjjm 6207 37 . . . cord-023095-4dannjjm 6208 1 Omeprazole omeprazole NN cord-023095-4dannjjm 6208 2 reduces reduce VBZ cord-023095-4dannjjm 6208 3 the the DT cord-023095-4dannjjm 6208 4 severity severity NN cord-023095-4dannjjm 6208 5 of of IN cord-023095-4dannjjm 6208 6 , , , cord-023095-4dannjjm 6208 7 but but CC cord-023095-4dannjjm 6208 8 does do VBZ cord-023095-4dannjjm 6208 9 not not RB cord-023095-4dannjjm 6208 10 completely completely RB cord-023095-4dannjjm 6208 11 prevent prevent VB cord-023095-4dannjjm 6208 12 , , , cord-023095-4dannjjm 6208 13 gastritis gastritis NN cord-023095-4dannjjm 6208 14 under under IN cord-023095-4dannjjm 6208 15 racing racing NN cord-023095-4dannjjm 6208 16 conditions condition NNS cord-023095-4dannjjm 6208 17 , , , cord-023095-4dannjjm 6208 18 and and CC cord-023095-4dannjjm 6208 19 can can MD cord-023095-4dannjjm 6208 20 be be VB cord-023095-4dannjjm 6208 21 difficult difficult JJ cord-023095-4dannjjm 6208 22 to to TO cord-023095-4dannjjm 6208 23 administer administer VB cord-023095-4dannjjm 6208 24 under under IN cord-023095-4dannjjm 6208 25 these these DT cord-023095-4dannjjm 6208 26 conditions condition NNS cord-023095-4dannjjm 6208 27 . . . cord-023095-4dannjjm 6209 1 Famotidine Famotidine NNP cord-023095-4dannjjm 6209 2 can can MD cord-023095-4dannjjm 6209 3 be be VB cord-023095-4dannjjm 6209 4 administered administer VBN cord-023095-4dannjjm 6209 5 in in IN cord-023095-4dannjjm 6209 6 food food NN cord-023095-4dannjjm 6209 7 , , , cord-023095-4dannjjm 6209 8 but but CC cord-023095-4dannjjm 6209 9 has have VBZ cord-023095-4dannjjm 6209 10 only only RB cord-023095-4dannjjm 6209 11 demonstrated demonstrate VBN cord-023095-4dannjjm 6209 12 efficacy efficacy NN cord-023095-4dannjjm 6209 13 under under IN cord-023095-4dannjjm 6209 14 less less RBR cord-023095-4dannjjm 6209 15 intense intense JJ cord-023095-4dannjjm 6209 16 training training NN cord-023095-4dannjjm 6209 17 conditions condition NNS cord-023095-4dannjjm 6209 18 . . . cord-023095-4dannjjm 6210 1 The the DT cord-023095-4dannjjm 6210 2 purpose purpose NN cord-023095-4dannjjm 6210 3 of of IN cord-023095-4dannjjm 6210 4 these these DT cord-023095-4dannjjm 6210 5 studies study NNS cord-023095-4dannjjm 6210 6 was be VBD cord-023095-4dannjjm 6210 7 to to TO cord-023095-4dannjjm 6210 8 evaluate evaluate VB cord-023095-4dannjjm 6210 9 different different JJ cord-023095-4dannjjm 6210 10 acid acid NN cord-023095-4dannjjm 6210 11 suppression suppression NN cord-023095-4dannjjm 6210 12 strategies strategy NNS cord-023095-4dannjjm 6210 13 under under IN cord-023095-4dannjjm 6210 14 racing racing NN cord-023095-4dannjjm 6210 15 conditions condition NNS cord-023095-4dannjjm 6210 16 for for IN cord-023095-4dannjjm 6210 17 the the DT cord-023095-4dannjjm 6210 18 prevention prevention NN cord-023095-4dannjjm 6210 19 of of IN cord-023095-4dannjjm 6210 20 exercise exercise NN cord-023095-4dannjjm 6210 21 - - HYPH cord-023095-4dannjjm 6210 22 induced induce VBN cord-023095-4dannjjm 6210 23 gastritis gastritis NN cord-023095-4dannjjm 6210 24 . . . cord-023095-4dannjjm 6211 1 Experiment experiment NN cord-023095-4dannjjm 6211 2 # # NN cord-023095-4dannjjm 6211 3 1 1 CD cord-023095-4dannjjm 6211 4 was be VBD cord-023095-4dannjjm 6211 5 a a DT cord-023095-4dannjjm 6211 6 randomized randomized JJ cord-023095-4dannjjm 6211 7 placebo placebo NN cord-023095-4dannjjm 6211 8 - - HYPH cord-023095-4dannjjm 6211 9 controlled control VBN cord-023095-4dannjjm 6211 10 study study NN cord-023095-4dannjjm 6211 11 using use VBG cord-023095-4dannjjm 6211 12 36 36 CD cord-023095-4dannjjm 6211 13 sled sled JJ cord-023095-4dannjjm 6211 14 dogs dog NNS cord-023095-4dannjjm 6211 15 ( ( -LRB- cord-023095-4dannjjm 6211 16 3 3 CD cord-023095-4dannjjm 6211 17 - - SYM cord-023095-4dannjjm 6211 18 8 8 CD cord-023095-4dannjjm 6211 19 years year NNS cord-023095-4dannjjm 6211 20 ) ) -RRB- cord-023095-4dannjjm 6211 21 competing compete VBG cord-023095-4dannjjm 6211 22 in in IN cord-023095-4dannjjm 6211 23 a a DT cord-023095-4dannjjm 6211 24 330 330 CD cord-023095-4dannjjm 6211 25 mile mile NN cord-023095-4dannjjm 6211 26 race race NN cord-023095-4dannjjm 6211 27 over over IN cord-023095-4dannjjm 6211 28 50 50 CD cord-023095-4dannjjm 6211 29 - - SYM cord-023095-4dannjjm 6211 30 60 60 CD cord-023095-4dannjjm 6211 31 h. h. NNP cord-023095-4dannjjm 6211 32 Treatment Treatment NNP cord-023095-4dannjjm 6211 33 groups group NNS cord-023095-4dannjjm 6212 1 were be VBD cord-023095-4dannjjm 6212 2 famotidine famotidine NNP cord-023095-4dannjjm 6212 3 ( ( -LRB- cord-023095-4dannjjm 6213 1 approx approx NN cord-023095-4dannjjm 6213 2 1 1 CD cord-023095-4dannjjm 6213 3 mg mg NNP cord-023095-4dannjjm 6213 4 / / SYM cord-023095-4dannjjm 6213 5 kg kg NNP cord-023095-4dannjjm 6213 6 qd qd NNP cord-023095-4dannjjm 6213 7 ) ) -RRB- cord-023095-4dannjjm 6213 8 or or CC cord-023095-4dannjjm 6213 9 no no DT cord-023095-4dannjjm 6213 10 treatment treatment NN cord-023095-4dannjjm 6213 11 , , , cord-023095-4dannjjm 6213 12 beginning begin VBG cord-023095-4dannjjm 6213 13 2 2 CD cord-023095-4dannjjm 6213 14 days day NNS cord-023095-4dannjjm 6213 15 prior prior RB cord-023095-4dannjjm 6213 16 to to IN cord-023095-4dannjjm 6213 17 the the DT cord-023095-4dannjjm 6213 18 start start NN cord-023095-4dannjjm 6213 19 of of IN cord-023095-4dannjjm 6213 20 the the DT cord-023095-4dannjjm 6213 21 race race NN cord-023095-4dannjjm 6213 22 and and CC cord-023095-4dannjjm 6213 23 proceeding proceeding NN cord-023095-4dannjjm 6213 24 until until IN cord-023095-4dannjjm 6213 25 gastroscopy gastroscopy NN cord-023095-4dannjjm 6213 26 was be VBD cord-023095-4dannjjm 6213 27 performed perform VBN cord-023095-4dannjjm 6213 28 24h 24h NNS cord-023095-4dannjjm 6213 29 after after IN cord-023095-4dannjjm 6213 30 the the DT cord-023095-4dannjjm 6213 31 race race NN cord-023095-4dannjjm 6213 32 . . . cord-023095-4dannjjm 6214 1 Experiment experiment NN cord-023095-4dannjjm 6214 2 # # NN cord-023095-4dannjjm 6214 3 2 2 CD cord-023095-4dannjjm 6214 4 was be VBD cord-023095-4dannjjm 6214 5 a a DT cord-023095-4dannjjm 6214 6 randomized randomized JJ cord-023095-4dannjjm 6214 7 positive positive JJ cord-023095-4dannjjm 6214 8 - - HYPH cord-023095-4dannjjm 6214 9 control control NN cord-023095-4dannjjm 6214 10 study study NN cord-023095-4dannjjm 6214 11 using use VBG cord-023095-4dannjjm 6214 12 52 52 CD cord-023095-4dannjjm 6214 13 sled sled JJ cord-023095-4dannjjm 6214 14 dogs dog NNS cord-023095-4dannjjm 6214 15 ( ( -LRB- cord-023095-4dannjjm 6214 16 2 2 CD cord-023095-4dannjjm 6214 17 - - SYM cord-023095-4dannjjm 6214 18 8 8 CD cord-023095-4dannjjm 6214 19 years year NNS cord-023095-4dannjjm 6214 20 ) ) -RRB- cord-023095-4dannjjm 6214 21 running run VBG cord-023095-4dannjjm 6214 22 a a DT cord-023095-4dannjjm 6214 23 mock mock JJ cord-023095-4dannjjm 6214 24 race race NN cord-023095-4dannjjm 6214 25 of of IN cord-023095-4dannjjm 6214 26 300 300 CD cord-023095-4dannjjm 6214 27 miles mile NNS cord-023095-4dannjjm 6214 28 in in IN cord-023095-4dannjjm 6214 29 50h 50h NNS cord-023095-4dannjjm 6214 30 . . . cord-023095-4dannjjm 6215 1 Dogs dog NNS cord-023095-4dannjjm 6215 2 were be VBD cord-023095-4dannjjm 6215 3 divided divide VBN cord-023095-4dannjjm 6215 4 into into IN cord-023095-4dannjjm 6215 5 omeprazole omeprazole NN cord-023095-4dannjjm 6215 6 ( ( -LRB- cord-023095-4dannjjm 6215 7 approx approx NN cord-023095-4dannjjm 6215 8 1 1 CD cord-023095-4dannjjm 6216 1 mg mg NNP cord-023095-4dannjjm 6216 2 / / SYM cord-023095-4dannjjm 6216 3 kg kg NNP cord-023095-4dannjjm 6216 4 qd qd NNP cord-023095-4dannjjm 6216 5 , , , cord-023095-4dannjjm 6216 6 administered administer VBD cord-023095-4dannjjm 6216 7 30 30 CD cord-023095-4dannjjm 6216 8 min min NN cord-023095-4dannjjm 6216 9 prior prior RB cord-023095-4dannjjm 6216 10 to to IN cord-023095-4dannjjm 6216 11 a a DT cord-023095-4dannjjm 6216 12 meal meal NN cord-023095-4dannjjm 6216 13 ) ) -RRB- cord-023095-4dannjjm 6216 14 or or CC cord-023095-4dannjjm 6216 15 famotidine famotidine NNP cord-023095-4dannjjm 6216 16 ( ( -LRB- cord-023095-4dannjjm 6216 17 approx approx NNP cord-023095-4dannjjm 6216 18 2 2 CD cord-023095-4dannjjm 6216 19 mg mg NNP cord-023095-4dannjjm 6216 20 / / SYM cord-023095-4dannjjm 6216 21 kg kg NN cord-023095-4dannjjm 6216 22 bid bid NN cord-023095-4dannjjm 6216 23 ) ) -RRB- cord-023095-4dannjjm 6216 24 groups group NNS cord-023095-4dannjjm 6216 25 beginning begin VBG cord-023095-4dannjjm 6216 26 2 2 CD cord-023095-4dannjjm 6216 27 days day NNS cord-023095-4dannjjm 6216 28 prior prior RB cord-023095-4dannjjm 6216 29 to to IN cord-023095-4dannjjm 6216 30 the the DT cord-023095-4dannjjm 6216 31 exercise exercise NN cord-023095-4dannjjm 6216 32 challenge challenge NN cord-023095-4dannjjm 6216 33 and and CC cord-023095-4dannjjm 6216 34 continuing continue VBG cord-023095-4dannjjm 6216 35 for for IN cord-023095-4dannjjm 6216 36 24h 24h NNS cord-023095-4dannjjm 6216 37 after after IN cord-023095-4dannjjm 6216 38 completion completion NN cord-023095-4dannjjm 6216 39 . . . cord-023095-4dannjjm 6217 1 Gastroscopy Gastroscopy NNP cord-023095-4dannjjm 6217 2 was be VBD cord-023095-4dannjjm 6217 3 performed perform VBN cord-023095-4dannjjm 6217 4 immediately immediately RB cord-023095-4dannjjm 6217 5 prior prior RB cord-023095-4dannjjm 6217 6 to to IN cord-023095-4dannjjm 6217 7 the the DT cord-023095-4dannjjm 6217 8 start start NN cord-023095-4dannjjm 6217 9 of of IN cord-023095-4dannjjm 6217 10 dosing dosing NN cord-023095-4dannjjm 6217 11 and and CC cord-023095-4dannjjm 6217 12 24h 24h NNS cord-023095-4dannjjm 6217 13 after after IN cord-023095-4dannjjm 6217 14 completion completion NN cord-023095-4dannjjm 6217 15 of of IN cord-023095-4dannjjm 6217 16 the the DT cord-023095-4dannjjm 6217 17 exercise exercise NN cord-023095-4dannjjm 6217 18 . . . cord-023095-4dannjjm 6218 1 In in IN cord-023095-4dannjjm 6218 2 all all DT cord-023095-4dannjjm 6218 3 cases case NNS cord-023095-4dannjjm 6218 4 , , , cord-023095-4dannjjm 6218 5 mucosal mucosal JJ cord-023095-4dannjjm 6218 6 appearance appearance NN cord-023095-4dannjjm 6218 7 during during IN cord-023095-4dannjjm 6218 8 gastroscopy gastroscopy NN cord-023095-4dannjjm 6218 9 was be VBD cord-023095-4dannjjm 6218 10 blindly blindly RB cord-023095-4dannjjm 6218 11 scored score VBN cord-023095-4dannjjm 6218 12 using use VBG cord-023095-4dannjjm 6218 13 previously previously RB cord-023095-4dannjjm 6218 14 described describe VBN cord-023095-4dannjjm 6218 15 scoring score VBG cord-023095-4dannjjm 6218 16 system system NN cord-023095-4dannjjm 6218 17 . . . cord-023095-4dannjjm 6219 1 Famotidine Famotidine NNP cord-023095-4dannjjm 6220 1 ( ( -LRB- cord-023095-4dannjjm 6220 2 1 1 CD cord-023095-4dannjjm 6220 3 mg mg NNP cord-023095-4dannjjm 6220 4 / / SYM cord-023095-4dannjjm 6220 5 kg kg NNP cord-023095-4dannjjm 6220 6 qd qd NNP cord-023095-4dannjjm 6220 7 ) ) -RRB- cord-023095-4dannjjm 6220 8 reduced reduce VBD cord-023095-4dannjjm 6220 9 the the DT cord-023095-4dannjjm 6220 10 prevalence prevalence NN cord-023095-4dannjjm 6220 11 of of IN cord-023095-4dannjjm 6220 12 clinicallyrelevant clinicallyrelevant JJ cord-023095-4dannjjm 6220 13 , , , cord-023095-4dannjjm 6220 14 exercise exercise NN cord-023095-4dannjjm 6220 15 - - HYPH cord-023095-4dannjjm 6220 16 induced induce VBN cord-023095-4dannjjm 6220 17 gastric gastric JJ cord-023095-4dannjjm 6220 18 lesions lesion NNS cord-023095-4dannjjm 6220 19 compared compare VBN cord-023095-4dannjjm 6220 20 to to IN cord-023095-4dannjjm 6220 21 no no DT cord-023095-4dannjjm 6220 22 treatment treatment NN cord-023095-4dannjjm 6220 23 ( ( -LRB- cord-023095-4dannjjm 6220 24 7/16 7/16 CD cord-023095-4dannjjm 6220 25 vs vs IN cord-023095-4dannjjm 6220 26 11/16 11/16 CD cord-023095-4dannjjm 6220 27 , , , cord-023095-4dannjjm 6220 28 p p NN cord-023095-4dannjjm 6220 29 5 5 CD cord-023095-4dannjjm 6220 30 0.031 0.031 CD cord-023095-4dannjjm 6220 31 ) ) -RRB- cord-023095-4dannjjm 6220 32 . . . cord-023095-4dannjjm 6221 1 Compared compare VBN cord-023095-4dannjjm 6221 2 to to IN cord-023095-4dannjjm 6221 3 famotidine famotidine NN cord-023095-4dannjjm 6221 4 at at IN cord-023095-4dannjjm 6221 5 2 2 CD cord-023095-4dannjjm 6221 6 mg mg NNP cord-023095-4dannjjm 6221 7 / / SYM cord-023095-4dannjjm 6221 8 kg kg NN cord-023095-4dannjjm 6221 9 bid bid NN cord-023095-4dannjjm 6221 10 , , , cord-023095-4dannjjm 6221 11 omeprazole omeprazole NN cord-023095-4dannjjm 6221 12 significantly significantly RB cord-023095-4dannjjm 6221 13 decreased decrease VBD cord-023095-4dannjjm 6221 14 the the DT cord-023095-4dannjjm 6221 15 severity severity NN cord-023095-4dannjjm 6221 16 ( ( -LRB- cord-023095-4dannjjm 6221 17 0.4 0.4 CD cord-023095-4dannjjm 6221 18 vs vs IN cord-023095-4dannjjm 6221 19 1.2 1.2 CD cord-023095-4dannjjm 6221 20 , , , cord-023095-4dannjjm 6221 21 p p NN cord-023095-4dannjjm 6221 22 5 5 CD cord-023095-4dannjjm 6221 23 0.0002 0.0002 CD cord-023095-4dannjjm 6221 24 ) ) -RRB- cord-023095-4dannjjm 6221 25 and and CC cord-023095-4dannjjm 6221 26 prevalence prevalence NN cord-023095-4dannjjm 6221 27 ( ( -LRB- cord-023095-4dannjjm 6221 28 2/23 2/23 CD cord-023095-4dannjjm 6221 29 vs vs IN cord-023095-4dannjjm 6221 30 7/21 7/21 CD cord-023095-4dannjjm 6221 31 , , , cord-023095-4dannjjm 6221 32 p p NN cord-023095-4dannjjm 6221 33 5 5 CD cord-023095-4dannjjm 6221 34 0.049 0.049 CD cord-023095-4dannjjm 6221 35 ) ) -RRB- cord-023095-4dannjjm 6221 36 of of IN cord-023095-4dannjjm 6221 37 gastric gastric JJ cord-023095-4dannjjm 6221 38 lesions lesion NNS cord-023095-4dannjjm 6221 39 . . . cord-023095-4dannjjm 6222 1 Although although IN cord-023095-4dannjjm 6222 2 famotidine famotidine NNP cord-023095-4dannjjm 6222 3 provides provide VBZ cord-023095-4dannjjm 6222 4 some some DT cord-023095-4dannjjm 6222 5 benefit benefit NN cord-023095-4dannjjm 6222 6 in in IN cord-023095-4dannjjm 6222 7 the the DT cord-023095-4dannjjm 6222 8 prevention prevention NN cord-023095-4dannjjm 6222 9 of of IN cord-023095-4dannjjm 6222 10 exercise exercise NN cord-023095-4dannjjm 6222 11 - - HYPH cord-023095-4dannjjm 6222 12 induced induce VBN cord-023095-4dannjjm 6222 13 gastric gastric JJ cord-023095-4dannjjm 6222 14 lesions lesion NNS cord-023095-4dannjjm 6222 15 , , , cord-023095-4dannjjm 6222 16 neither neither CC cord-023095-4dannjjm 6222 17 the the DT cord-023095-4dannjjm 6222 18 recommended recommend VBN cord-023095-4dannjjm 6222 19 dose dose NN cord-023095-4dannjjm 6222 20 nor nor CC cord-023095-4dannjjm 6222 21 the the DT cord-023095-4dannjjm 6222 22 higher high JJR cord-023095-4dannjjm 6222 23 dose dose NN cord-023095-4dannjjm 6222 24 were be VBD cord-023095-4dannjjm 6222 25 considered consider VBN cord-023095-4dannjjm 6222 26 acceptable acceptable JJ cord-023095-4dannjjm 6222 27 in in IN cord-023095-4dannjjm 6222 28 the the DT cord-023095-4dannjjm 6222 29 prevention prevention NN cord-023095-4dannjjm 6222 30 of of IN cord-023095-4dannjjm 6222 31 exerciseinduced exerciseinduce VBN cord-023095-4dannjjm 6222 32 gastritis gastritis NN cord-023095-4dannjjm 6222 33 as as IN cord-023095-4dannjjm 6222 34 between between IN cord-023095-4dannjjm 6222 35 33 33 CD cord-023095-4dannjjm 6222 36 - - SYM cord-023095-4dannjjm 6222 37 44 44 CD cord-023095-4dannjjm 6222 38 % % NN cord-023095-4dannjjm 6222 39 of of IN cord-023095-4dannjjm 6222 40 the the DT cord-023095-4dannjjm 6222 41 dogs dog NNS cord-023095-4dannjjm 6222 42 receiving receive VBG cord-023095-4dannjjm 6222 43 famotidine famotidine NN cord-023095-4dannjjm 6222 44 had have VBD cord-023095-4dannjjm 6222 45 clinically clinically RB cord-023095-4dannjjm 6222 46 significant significant JJ cord-023095-4dannjjm 6222 47 lesions lesion NNS cord-023095-4dannjjm 6222 48 . . . cord-023095-4dannjjm 6223 1 A a DT cord-023095-4dannjjm 6223 2 previous previous JJ cord-023095-4dannjjm 6223 3 study study NN cord-023095-4dannjjm 6223 4 examining examine VBG cord-023095-4dannjjm 6223 5 omeprazole omeprazole NN cord-023095-4dannjjm 6223 6 under under IN cord-023095-4dannjjm 6223 7 racing racing NN cord-023095-4dannjjm 6223 8 conditions condition NNS cord-023095-4dannjjm 6223 9 , , , cord-023095-4dannjjm 6223 10 but but CC cord-023095-4dannjjm 6223 11 without without IN cord-023095-4dannjjm 6223 12 careful careful JJ cord-023095-4dannjjm 6223 13 administration administration NN cord-023095-4dannjjm 6223 14 on on IN cord-023095-4dannjjm 6223 15 an an DT cord-023095-4dannjjm 6223 16 empty empty JJ cord-023095-4dannjjm 6223 17 stomach stomach NN cord-023095-4dannjjm 6223 18 , , , cord-023095-4dannjjm 6223 19 resulted result VBD cord-023095-4dannjjm 6223 20 in in IN cord-023095-4dannjjm 6223 21 a a DT cord-023095-4dannjjm 6223 22 22 22 CD cord-023095-4dannjjm 6223 23 % % NN cord-023095-4dannjjm 6223 24 prevalence prevalence NN cord-023095-4dannjjm 6223 25 of of IN cord-023095-4dannjjm 6223 26 clinically clinically RB cord-023095-4dannjjm 6223 27 significant significant JJ cord-023095-4dannjjm 6223 28 gastric gastric JJ cord-023095-4dannjjm 6223 29 lesions lesion NNS cord-023095-4dannjjm 6223 30 . . . cord-023095-4dannjjm 6224 1 However however RB cord-023095-4dannjjm 6224 2 , , , cord-023095-4dannjjm 6224 3 the the DT cord-023095-4dannjjm 6224 4 bioavailability bioavailability NN cord-023095-4dannjjm 6224 5 of of IN cord-023095-4dannjjm 6224 6 omeprazole omeprazole NN cord-023095-4dannjjm 6224 7 is be VBZ cord-023095-4dannjjm 6224 8 reduced reduce VBN cord-023095-4dannjjm 6224 9 in in IN cord-023095-4dannjjm 6224 10 the the DT cord-023095-4dannjjm 6224 11 presence presence NN cord-023095-4dannjjm 6224 12 of of IN cord-023095-4dannjjm 6224 13 food food NN cord-023095-4dannjjm 6224 14 , , , cord-023095-4dannjjm 6224 15 and and CC cord-023095-4dannjjm 6224 16 when when WRB cord-023095-4dannjjm 6224 17 the the DT cord-023095-4dannjjm 6224 18 daily daily JJ cord-023095-4dannjjm 6224 19 administration administration NN cord-023095-4dannjjm 6224 20 of of IN cord-023095-4dannjjm 6224 21 the the DT cord-023095-4dannjjm 6224 22 drug drug NN cord-023095-4dannjjm 6224 23 is be VBZ cord-023095-4dannjjm 6224 24 carefully carefully RB cord-023095-4dannjjm 6224 25 scheduled schedule VBN cord-023095-4dannjjm 6224 26 to to TO cord-023095-4dannjjm 6224 27 coincide coincide VB cord-023095-4dannjjm 6224 28 with with IN cord-023095-4dannjjm 6224 29 an an DT cord-023095-4dannjjm 6224 30 empty empty JJ cord-023095-4dannjjm 6224 31 stomach stomach NN cord-023095-4dannjjm 6224 32 , , , cord-023095-4dannjjm 6224 33 the the DT cord-023095-4dannjjm 6224 34 resulting result VBG cord-023095-4dannjjm 6224 35 prevalence prevalence NN cord-023095-4dannjjm 6224 36 of of IN cord-023095-4dannjjm 6224 37 clinically clinically RB cord-023095-4dannjjm 6224 38 significant significant JJ cord-023095-4dannjjm 6224 39 lesions lesion NNS cord-023095-4dannjjm 6224 40 induced induce VBN cord-023095-4dannjjm 6224 41 by by IN cord-023095-4dannjjm 6224 42 racing racing NN cord-023095-4dannjjm 6224 43 - - HYPH cord-023095-4dannjjm 6224 44 intensity intensity NN cord-023095-4dannjjm 6224 45 exercise exercise NN cord-023095-4dannjjm 6224 46 is be VBZ cord-023095-4dannjjm 6224 47 reduced reduce VBN cord-023095-4dannjjm 6224 48 to to IN cord-023095-4dannjjm 6224 49 just just RB cord-023095-4dannjjm 6224 50 over over IN cord-023095-4dannjjm 6224 51 10 10 CD cord-023095-4dannjjm 6224 52 % % NN cord-023095-4dannjjm 6224 53 . . . cord-023095-4dannjjm 6225 1 The the DT cord-023095-4dannjjm 6225 2 conclusions conclusion NNS cord-023095-4dannjjm 6225 3 of of IN cord-023095-4dannjjm 6225 4 these these DT cord-023095-4dannjjm 6225 5 studies study NNS cord-023095-4dannjjm 6225 6 are be VBP cord-023095-4dannjjm 6225 7 that that IN cord-023095-4dannjjm 6225 8 omeprazole omeprazole NN cord-023095-4dannjjm 6225 9 is be VBZ cord-023095-4dannjjm 6225 10 superior superior JJ cord-023095-4dannjjm 6225 11 to to IN cord-023095-4dannjjm 6225 12 famotidine famotidine NN cord-023095-4dannjjm 6225 13 in in IN cord-023095-4dannjjm 6225 14 preventing prevent VBG cord-023095-4dannjjm 6225 15 gastritis gastritis NN cord-023095-4dannjjm 6225 16 in in IN cord-023095-4dannjjm 6225 17 racing racing NN cord-023095-4dannjjm 6225 18 sled sled JJ cord-023095-4dannjjm 6225 19 dogs dog NNS cord-023095-4dannjjm 6225 20 during during IN cord-023095-4dannjjm 6225 21 competition competition NN cord-023095-4dannjjm 6225 22 . . . cord-023095-4dannjjm 6226 1 Routine routine JJ cord-023095-4dannjjm 6226 2 administration administration NN cord-023095-4dannjjm 6226 3 of of IN cord-023095-4dannjjm 6226 4 omeprazole omeprazole NNP cord-023095-4dannjjm 6226 5 is be VBZ cord-023095-4dannjjm 6226 6 recommended recommend VBN cord-023095-4dannjjm 6226 7 to to TO cord-023095-4dannjjm 6226 8 prevent prevent VB cord-023095-4dannjjm 6226 9 stress stress NN cord-023095-4dannjjm 6226 10 - - HYPH cord-023095-4dannjjm 6226 11 associated associate VBN cord-023095-4dannjjm 6226 12 gastric gastric JJ cord-023095-4dannjjm 6226 13 disease disease NN cord-023095-4dannjjm 6226 14 in in IN cord-023095-4dannjjm 6226 15 exercising exercise VBG cord-023095-4dannjjm 6226 16 and and CC cord-023095-4dannjjm 6226 17 racing race VBG cord-023095-4dannjjm 6226 18 Alaskan alaskan JJ cord-023095-4dannjjm 6226 19 sled sle VBN cord-023095-4dannjjm 6226 20 dogs dog NNS cord-023095-4dannjjm 6226 21 . . . cord-023095-4dannjjm 6227 1 Mares mare NNS cord-023095-4dannjjm 6227 2 may may MD cord-023095-4dannjjm 6227 3 be be VB cord-023095-4dannjjm 6227 4 an an DT cord-023095-4dannjjm 6227 5 important important JJ cord-023095-4dannjjm 6227 6 source source NN cord-023095-4dannjjm 6227 7 of of IN cord-023095-4dannjjm 6227 8 environmental environmental JJ cord-023095-4dannjjm 6227 9 contamination contamination NN cord-023095-4dannjjm 6227 10 with with IN cord-023095-4dannjjm 6227 11 Rhodococcus Rhodococcus NNP cord-023095-4dannjjm 6227 12 equi equi NN cord-023095-4dannjjm 6227 13 on on IN cord-023095-4dannjjm 6227 14 breeding breed VBG cord-023095-4dannjjm 6227 15 farms farm NNS cord-023095-4dannjjm 6227 16 . . . cord-023095-4dannjjm 6228 1 Attempts attempt NNS cord-023095-4dannjjm 6228 2 to to TO cord-023095-4dannjjm 6228 3 reduce reduce VB cord-023095-4dannjjm 6228 4 fecal fecal JJ cord-023095-4dannjjm 6228 5 shedding shedding NN cord-023095-4dannjjm 6228 6 of of IN cord-023095-4dannjjm 6228 7 R r NN cord-023095-4dannjjm 6228 8 equi equi NN cord-023095-4dannjjm 6228 9 by by IN cord-023095-4dannjjm 6228 10 the the DT cord-023095-4dannjjm 6228 11 mare mare NN cord-023095-4dannjjm 6228 12 and and CC cord-023095-4dannjjm 6228 13 the the DT cord-023095-4dannjjm 6228 14 effects effect NNS cord-023095-4dannjjm 6228 15 of of IN cord-023095-4dannjjm 6228 16 the the DT cord-023095-4dannjjm 6228 17 mare mare NN cord-023095-4dannjjm 6228 18 's 's POS cord-023095-4dannjjm 6228 19 fecal fecal JJ cord-023095-4dannjjm 6228 20 R r NN cord-023095-4dannjjm 6228 21 equi equi NN cord-023095-4dannjjm 6228 22 concentration concentration NN cord-023095-4dannjjm 6228 23 on on IN cord-023095-4dannjjm 6228 24 airborne airborne JJ cord-023095-4dannjjm 6228 25 concentrations concentration NNS cord-023095-4dannjjm 6228 26 in in IN cord-023095-4dannjjm 6228 27 the the DT cord-023095-4dannjjm 6228 28 foaling foaling NN cord-023095-4dannjjm 6228 29 stall stall NN cord-023095-4dannjjm 6228 30 have have VBP cord-023095-4dannjjm 6228 31 not not RB cord-023095-4dannjjm 6228 32 been be VBN cord-023095-4dannjjm 6228 33 previously previously RB cord-023095-4dannjjm 6228 34 reported report VBN cord-023095-4dannjjm 6228 35 . . . cord-023095-4dannjjm 6229 1 Twenty twenty CD cord-023095-4dannjjm 6229 2 - - HYPH cord-023095-4dannjjm 6229 3 one one CD cord-023095-4dannjjm 6229 4 Arabian arabian JJ cord-023095-4dannjjm 6229 5 mares mare NNS cord-023095-4dannjjm 6229 6 were be VBD cord-023095-4dannjjm 6229 7 treated treat VBN cord-023095-4dannjjm 6229 8 daily daily RB cord-023095-4dannjjm 6229 9 with with IN cord-023095-4dannjjm 6229 10 either either DT cord-023095-4dannjjm 6229 11 oral oral JJ cord-023095-4dannjjm 6229 12 gallium gallium NN cord-023095-4dannjjm 6229 13 nitrate nitrate NN cord-023095-4dannjjm 6229 14 or or CC cord-023095-4dannjjm 6229 15 placebo placebo NN cord-023095-4dannjjm 6229 16 in in IN cord-023095-4dannjjm 6229 17 a a DT cord-023095-4dannjjm 6229 18 randomized randomized JJ cord-023095-4dannjjm 6229 19 double double JJ cord-023095-4dannjjm 6229 20 - - HYPH cord-023095-4dannjjm 6229 21 blind blind JJ cord-023095-4dannjjm 6229 22 study study NN cord-023095-4dannjjm 6229 23 . . . cord-023095-4dannjjm 6230 1 Fecal fecal JJ cord-023095-4dannjjm 6230 2 samples sample NNS cord-023095-4dannjjm 6230 3 were be VBD cord-023095-4dannjjm 6230 4 collected collect VBN cord-023095-4dannjjm 6230 5 at at IN cord-023095-4dannjjm 6230 6 day day NN cord-023095-4dannjjm 6230 7 320 320 CD cord-023095-4dannjjm 6230 8 of of IN cord-023095-4dannjjm 6230 9 gestation gestation NN cord-023095-4dannjjm 6230 10 ( ( -LRB- cord-023095-4dannjjm 6230 11 time time NN cord-023095-4dannjjm 6230 12 1 1 CD cord-023095-4dannjjm 6230 13 ) ) -RRB- cord-023095-4dannjjm 6230 14 , , , cord-023095-4dannjjm 6230 15 the the DT cord-023095-4dannjjm 6230 16 week week NN cord-023095-4dannjjm 6230 17 before before IN cord-023095-4dannjjm 6230 18 foaling foal VBG cord-023095-4dannjjm 6230 19 ( ( -LRB- cord-023095-4dannjjm 6230 20 time time NN cord-023095-4dannjjm 6230 21 2 2 CD cord-023095-4dannjjm 6230 22 ) ) -RRB- cord-023095-4dannjjm 6230 23 , , , cord-023095-4dannjjm 6230 24 and and CC cord-023095-4dannjjm 6230 25 the the DT cord-023095-4dannjjm 6230 26 week week NN cord-023095-4dannjjm 6230 27 after after IN cord-023095-4dannjjm 6230 28 foaling foal VBG cord-023095-4dannjjm 6230 29 ( ( -LRB- cord-023095-4dannjjm 6230 30 time time NN cord-023095-4dannjjm 6230 31 3 3 CD cord-023095-4dannjjm 6230 32 ) ) -RRB- cord-023095-4dannjjm 6230 33 . . . cord-023095-4dannjjm 6231 1 Airborne airborne JJ cord-023095-4dannjjm 6231 2 concentration concentration NN cord-023095-4dannjjm 6231 3 of of IN cord-023095-4dannjjm 6231 4 R r NN cord-023095-4dannjjm 6231 5 equi equi NN cord-023095-4dannjjm 6231 6 were be VBD cord-023095-4dannjjm 6231 7 measured measure VBN cord-023095-4dannjjm 6231 8 in in IN cord-023095-4dannjjm 6231 9 the the DT cord-023095-4dannjjm 6231 10 stall stall NN cord-023095-4dannjjm 6231 11 within within IN cord-023095-4dannjjm 6231 12 6 6 CD cord-023095-4dannjjm 6231 13 hours hour NNS cord-023095-4dannjjm 6231 14 post post NN cord-023095-4dannjjm 6231 15 foaling foaling NN cord-023095-4dannjjm 6231 16 using use VBG cord-023095-4dannjjm 6231 17 a a DT cord-023095-4dannjjm 6231 18 microbial microbial JJ cord-023095-4dannjjm 6231 19 air air NN cord-023095-4dannjjm 6231 20 sampling sampling NN cord-023095-4dannjjm 6231 21 system system NN cord-023095-4dannjjm 6231 22 into into IN cord-023095-4dannjjm 6231 23 which which WDT cord-023095-4dannjjm 6231 24 standard standard NN cord-023095-4dannjjm 6231 25 ( ( -LRB- cord-023095-4dannjjm 6231 26 100-mm 100-mm CD cord-023095-4dannjjm 6231 27 ) ) -RRB- cord-023095-4dannjjm 6231 28 culture culture NN cord-023095-4dannjjm 6231 29 plates plate NNS cord-023095-4dannjjm 6231 30 with with IN cord-023095-4dannjjm 6231 31 a a DT cord-023095-4dannjjm 6231 32 media medium NNS cord-023095-4dannjjm 6231 33 selective selective JJ cord-023095-4dannjjm 6231 34 for for IN cord-023095-4dannjjm 6231 35 R. R. NNP cord-023095-4dannjjm 6231 36 equi equi NN cord-023095-4dannjjm 6231 37 have have VBP cord-023095-4dannjjm 6231 38 been be VBN cord-023095-4dannjjm 6231 39 loaded load VBN cord-023095-4dannjjm 6231 40 . . . cord-023095-4dannjjm 6232 1 Concentration concentration NN cord-023095-4dannjjm 6232 2 of of IN cord-023095-4dannjjm 6232 3 total total JJ cord-023095-4dannjjm 6232 4 R r NN cord-023095-4dannjjm 6232 5 equi equi NN cord-023095-4dannjjm 6232 6 were be VBD cord-023095-4dannjjm 6232 7 determined determine VBN cord-023095-4dannjjm 6232 8 by by IN cord-023095-4dannjjm 6232 9 morphological morphological JJ cord-023095-4dannjjm 6232 10 characteristics characteristic NNS cord-023095-4dannjjm 6232 11 . . . cord-023095-4dannjjm 6233 1 The the DT cord-023095-4dannjjm 6233 2 concentration concentration NN cord-023095-4dannjjm 6233 3 of of IN cord-023095-4dannjjm 6233 4 virulent virulent JJ cord-023095-4dannjjm 6233 5 R r NN cord-023095-4dannjjm 6233 6 equi equi NN cord-023095-4dannjjm 6233 7 was be VBD cord-023095-4dannjjm 6233 8 determined determine VBN cord-023095-4dannjjm 6233 9 using use VBG cord-023095-4dannjjm 6233 10 a a DT cord-023095-4dannjjm 6233 11 modified modify VBN cord-023095-4dannjjm 6233 12 colony colony NN cord-023095-4dannjjm 6233 13 immunoblot immunoblot NN cord-023095-4dannjjm 6233 14 method method NN cord-023095-4dannjjm 6233 15 . . . cord-023095-4dannjjm 6234 1 Concentrations concentration NNS cord-023095-4dannjjm 6234 2 of of IN cord-023095-4dannjjm 6234 3 total total JJ cord-023095-4dannjjm 6234 4 and and CC cord-023095-4dannjjm 6234 5 virulent virulent JJ cord-023095-4dannjjm 6234 6 R r NN cord-023095-4dannjjm 6234 7 equi equi NN cord-023095-4dannjjm 6234 8 were be VBD cord-023095-4dannjjm 6234 9 compared compare VBN cord-023095-4dannjjm 6234 10 among among IN cord-023095-4dannjjm 6234 11 mares mare NNS cord-023095-4dannjjm 6234 12 to to TO cord-023095-4dannjjm 6234 13 examine examine VB cord-023095-4dannjjm 6234 14 effects effect NNS cord-023095-4dannjjm 6234 15 of of IN cord-023095-4dannjjm 6234 16 treatment treatment NN cord-023095-4dannjjm 6234 17 , , , cord-023095-4dannjjm 6234 18 time time NN cord-023095-4dannjjm 6234 19 , , , cord-023095-4dannjjm 6234 20 and and CC cord-023095-4dannjjm 6234 21 treatment treatment NN cord-023095-4dannjjm 6234 22 by by IN cord-023095-4dannjjm 6234 23 time time NN cord-023095-4dannjjm 6234 24 interaction interaction NN cord-023095-4dannjjm 6234 25 . . . cord-023095-4dannjjm 6235 1 There there EX cord-023095-4dannjjm 6235 2 were be VBD cord-023095-4dannjjm 6235 3 significant significant JJ cord-023095-4dannjjm 6235 4 ( ( -LRB- cord-023095-4dannjjm 6235 5 P p NN cord-023095-4dannjjm 6235 6 o o NN cord-023095-4dannjjm 6235 7 0.05 0.05 CD cord-023095-4dannjjm 6235 8 ) ) -RRB- cord-023095-4dannjjm 6235 9 effects effect NNS cord-023095-4dannjjm 6235 10 of of IN cord-023095-4dannjjm 6235 11 treatment treatment NN cord-023095-4dannjjm 6235 12 that that WDT cord-023095-4dannjjm 6235 13 depended depend VBD cord-023095-4dannjjm 6235 14 on on IN cord-023095-4dannjjm 6235 15 time time NN cord-023095-4dannjjm 6235 16 of of IN cord-023095-4dannjjm 6235 17 sample sample NN cord-023095-4dannjjm 6235 18 collection collection NN cord-023095-4dannjjm 6235 19 . . . cord-023095-4dannjjm 6236 1 At at IN cord-023095-4dannjjm 6236 2 sample sample NN cord-023095-4dannjjm 6236 3 times time NNS cord-023095-4dannjjm 6236 4 1 1 CD cord-023095-4dannjjm 6236 5 and and CC cord-023095-4dannjjm 6236 6 2 2 CD cord-023095-4dannjjm 6236 7 there there EX cord-023095-4dannjjm 6236 8 were be VBD cord-023095-4dannjjm 6236 9 no no DT cord-023095-4dannjjm 6236 10 significant significant JJ cord-023095-4dannjjm 6236 11 differences difference NNS cord-023095-4dannjjm 6236 12 between between IN cord-023095-4dannjjm 6236 13 groups group NNS cord-023095-4dannjjm 6236 14 in in IN cord-023095-4dannjjm 6236 15 the the DT cord-023095-4dannjjm 6236 16 fecal fecal JJ cord-023095-4dannjjm 6236 17 concentration concentration NN cord-023095-4dannjjm 6236 18 of of IN cord-023095-4dannjjm 6236 19 virulent virulent JJ cord-023095-4dannjjm 6236 20 R r NN cord-023095-4dannjjm 6236 21 equi equi NN cord-023095-4dannjjm 6236 22 . . . cord-023095-4dannjjm 6237 1 At at IN cord-023095-4dannjjm 6237 2 time time NN cord-023095-4dannjjm 6237 3 3 3 CD cord-023095-4dannjjm 6237 4 concentrations concentration NNS cord-023095-4dannjjm 6237 5 of of IN cord-023095-4dannjjm 6237 6 virulent virulent JJ cord-023095-4dannjjm 6237 7 R r NN cord-023095-4dannjjm 6237 8 equi equi NN cord-023095-4dannjjm 6237 9 were be VBD cord-023095-4dannjjm 6237 10 significantly significantly RB cord-023095-4dannjjm 6237 11 lower low JJR cord-023095-4dannjjm 6237 12 among among IN cord-023095-4dannjjm 6237 13 mares mare NNS cord-023095-4dannjjm 6237 14 in in IN cord-023095-4dannjjm 6237 15 the the DT cord-023095-4dannjjm 6237 16 treatment treatment NN cord-023095-4dannjjm 6237 17 group group NN cord-023095-4dannjjm 6237 18 ( ( -LRB- cord-023095-4dannjjm 6237 19 P p NN cord-023095-4dannjjm 6237 20 o o NN cord-023095-4dannjjm 6237 21 0.05 0.05 CD cord-023095-4dannjjm 6237 22 ) ) -RRB- cord-023095-4dannjjm 6237 23 compared compare VBN cord-023095-4dannjjm 6237 24 to to IN cord-023095-4dannjjm 6237 25 control control NN cord-023095-4dannjjm 6237 26 . . . cord-023095-4dannjjm 6238 1 Effects effect NNS cord-023095-4dannjjm 6238 2 of of IN cord-023095-4dannjjm 6238 3 time time NN cord-023095-4dannjjm 6238 4 depended depend VBD cord-023095-4dannjjm 6238 5 significantly significantly RB cord-023095-4dannjjm 6238 6 on on IN cord-023095-4dannjjm 6238 7 groups group NNS cord-023095-4dannjjm 6238 8 : : : cord-023095-4dannjjm 6238 9 for for IN cord-023095-4dannjjm 6238 10 the the DT cord-023095-4dannjjm 6238 11 control control NN cord-023095-4dannjjm 6238 12 group group NN cord-023095-4dannjjm 6238 13 , , , cord-023095-4dannjjm 6238 14 there there EX cord-023095-4dannjjm 6238 15 were be VBD cord-023095-4dannjjm 6238 16 no no DT cord-023095-4dannjjm 6238 17 significant significant JJ cord-023095-4dannjjm 6238 18 effects effect NNS cord-023095-4dannjjm 6238 19 of of IN cord-023095-4dannjjm 6238 20 time time NN cord-023095-4dannjjm 6238 21 . . . cord-023095-4dannjjm 6239 1 For for IN cord-023095-4dannjjm 6239 2 the the DT cord-023095-4dannjjm 6239 3 treatment treatment NN cord-023095-4dannjjm 6239 4 group group NN cord-023095-4dannjjm 6239 5 , , , cord-023095-4dannjjm 6239 6 concentrations concentration NNS cord-023095-4dannjjm 6239 7 tended tend VBD cord-023095-4dannjjm 6239 8 to to TO cord-023095-4dannjjm 6239 9 decrease decrease VB cord-023095-4dannjjm 6239 10 over over IN cord-023095-4dannjjm 6239 11 time time NN cord-023095-4dannjjm 6239 12 , , , cord-023095-4dannjjm 6239 13 and and CC cord-023095-4dannjjm 6239 14 concentrations concentration NNS cord-023095-4dannjjm 6239 15 at at IN cord-023095-4dannjjm 6239 16 time time NN cord-023095-4dannjjm 6239 17 3 3 CD cord-023095-4dannjjm 6239 18 were be VBD cord-023095-4dannjjm 6239 19 significantly significantly RB cord-023095-4dannjjm 6239 20 ( ( -LRB- cord-023095-4dannjjm 6239 21 P p NN cord-023095-4dannjjm 6239 22 o o NN cord-023095-4dannjjm 6239 23 0.05 0.05 CD cord-023095-4dannjjm 6239 24 ) ) -RRB- cord-023095-4dannjjm 6239 25 lower low JJR cord-023095-4dannjjm 6239 26 than than IN cord-023095-4dannjjm 6239 27 those those DT cord-023095-4dannjjm 6239 28 at at IN cord-023095-4dannjjm 6239 29 time time NN cord-023095-4dannjjm 6239 30 1 1 CD cord-023095-4dannjjm 6239 31 . . . cord-023095-4dannjjm 6240 1 No no DT cord-023095-4dannjjm 6240 2 other other JJ cord-023095-4dannjjm 6240 3 differences difference NNS cord-023095-4dannjjm 6240 4 among among IN cord-023095-4dannjjm 6240 5 times time NNS cord-023095-4dannjjm 6240 6 for for IN cord-023095-4dannjjm 6240 7 concentrations concentration NNS cord-023095-4dannjjm 6240 8 in in IN cord-023095-4dannjjm 6240 9 the the DT cord-023095-4dannjjm 6240 10 treatment treatment NN cord-023095-4dannjjm 6240 11 group group NN cord-023095-4dannjjm 6240 12 were be VBD cord-023095-4dannjjm 6240 13 statistically statistically RB cord-023095-4dannjjm 6240 14 significant significant JJ cord-023095-4dannjjm 6240 15 . . . cord-023095-4dannjjm 6241 1 There there EX cord-023095-4dannjjm 6241 2 were be VBD cord-023095-4dannjjm 6241 3 no no DT cord-023095-4dannjjm 6241 4 significant significant JJ cord-023095-4dannjjm 6241 5 effects effect NNS cord-023095-4dannjjm 6241 6 of of IN cord-023095-4dannjjm 6241 7 treatment treatment NN cord-023095-4dannjjm 6241 8 , , , cord-023095-4dannjjm 6241 9 sample sample NN cord-023095-4dannjjm 6241 10 time time NN cord-023095-4dannjjm 6241 11 , , , cord-023095-4dannjjm 6241 12 or or CC cord-023095-4dannjjm 6241 13 their -PRON- PRP$ cord-023095-4dannjjm 6241 14 interaction interaction NN cord-023095-4dannjjm 6241 15 on on IN cord-023095-4dannjjm 6241 16 the the DT cord-023095-4dannjjm 6241 17 concentration concentration NN cord-023095-4dannjjm 6241 18 of of IN cord-023095-4dannjjm 6241 19 total total JJ cord-023095-4dannjjm 6241 20 R r NN cord-023095-4dannjjm 6241 21 equi equi NN cord-023095-4dannjjm 6241 22 between between IN cord-023095-4dannjjm 6241 23 groups group NNS cord-023095-4dannjjm 6241 24 ; ; : cord-023095-4dannjjm 6241 25 however however RB cord-023095-4dannjjm 6241 26 , , , cord-023095-4dannjjm 6241 27 the the DT cord-023095-4dannjjm 6241 28 pattern pattern NN cord-023095-4dannjjm 6241 29 for for IN cord-023095-4dannjjm 6241 30 these these DT cord-023095-4dannjjm 6241 31 data datum NNS cord-023095-4dannjjm 6241 32 was be VBD cord-023095-4dannjjm 6241 33 similar similar JJ cord-023095-4dannjjm 6241 34 to to IN cord-023095-4dannjjm 6242 1 that that DT cord-023095-4dannjjm 6242 2 observed observe VBD cord-023095-4dannjjm 6242 3 for for IN cord-023095-4dannjjm 6242 4 the the DT cord-023095-4dannjjm 6242 5 virulent virulent JJ cord-023095-4dannjjm 6242 6 isolates isolate NNS cord-023095-4dannjjm 6242 7 . . . cord-023095-4dannjjm 6243 1 No no DT cord-023095-4dannjjm 6243 2 significant significant JJ cord-023095-4dannjjm 6243 3 differences difference NNS cord-023095-4dannjjm 6243 4 were be VBD cord-023095-4dannjjm 6243 5 determined determine VBN cord-023095-4dannjjm 6243 6 between between IN cord-023095-4dannjjm 6243 7 treatment treatment NN cord-023095-4dannjjm 6243 8 groups group NNS cord-023095-4dannjjm 6243 9 for for IN cord-023095-4dannjjm 6243 10 airborne airborne JJ cord-023095-4dannjjm 6243 11 concentrations concentration NNS cord-023095-4dannjjm 6243 12 of of IN cord-023095-4dannjjm 6243 13 virulent virulent JJ cord-023095-4dannjjm 6243 14 or or CC cord-023095-4dannjjm 6243 15 total total JJ cord-023095-4dannjjm 6243 16 R r NN cord-023095-4dannjjm 6243 17 equi equi NN cord-023095-4dannjjm 6243 18 . . . cord-023095-4dannjjm 6244 1 Treatment treatment NN cord-023095-4dannjjm 6244 2 of of IN cord-023095-4dannjjm 6244 3 mares mare NNS cord-023095-4dannjjm 6244 4 with with IN cord-023095-4dannjjm 6244 5 oral oral JJ cord-023095-4dannjjm 6244 6 gallium gallium NN cord-023095-4dannjjm 6244 7 nitrate nitrate NN cord-023095-4dannjjm 6244 8 significantly significantly RB cord-023095-4dannjjm 6244 9 reduced reduce VBD cord-023095-4dannjjm 6244 10 the the DT cord-023095-4dannjjm 6244 11 fecal fecal JJ cord-023095-4dannjjm 6244 12 concentrations concentration NNS cord-023095-4dannjjm 6244 13 of of IN cord-023095-4dannjjm 6244 14 virulent virulent JJ cord-023095-4dannjjm 6244 15 R r NN cord-023095-4dannjjm 6244 16 equi equi NN cord-023095-4dannjjm 6244 17 over over IN cord-023095-4dannjjm 6244 18 time time NN cord-023095-4dannjjm 6244 19 , , , cord-023095-4dannjjm 6244 20 but but CC cord-023095-4dannjjm 6244 21 had have VBD cord-023095-4dannjjm 6244 22 no no DT cord-023095-4dannjjm 6244 23 impact impact NN cord-023095-4dannjjm 6244 24 on on IN cord-023095-4dannjjm 6244 25 the the DT cord-023095-4dannjjm 6244 26 airborne airborne JJ cord-023095-4dannjjm 6244 27 concentration concentration NN cord-023095-4dannjjm 6244 28 of of IN cord-023095-4dannjjm 6244 29 R r NN cord-023095-4dannjjm 6244 30 equi equi NN cord-023095-4dannjjm 6244 31 shortly shortly RB cord-023095-4dannjjm 6244 32 after after IN cord-023095-4dannjjm 6244 33 foaling foal VBG cord-023095-4dannjjm 6244 34 . . . cord-023095-4dannjjm 6245 1 The the DT cord-023095-4dannjjm 6245 2 purpose purpose NN cord-023095-4dannjjm 6245 3 of of IN cord-023095-4dannjjm 6245 4 this this DT cord-023095-4dannjjm 6245 5 study study NN cord-023095-4dannjjm 6245 6 was be VBD cord-023095-4dannjjm 6245 7 to to TO cord-023095-4dannjjm 6245 8 evaluate evaluate VB cord-023095-4dannjjm 6245 9 the the DT cord-023095-4dannjjm 6245 10 protein protein NN cord-023095-4dannjjm 6245 11 profile profile NN cord-023095-4dannjjm 6245 12 of of IN cord-023095-4dannjjm 6245 13 bronchoalveolar bronchoalveolar NNP cord-023095-4dannjjm 6245 14 lavage lavage NN cord-023095-4dannjjm 6245 15 fluid fluid NN cord-023095-4dannjjm 6245 16 ( ( -LRB- cord-023095-4dannjjm 6245 17 BALF BALF NNP cord-023095-4dannjjm 6245 18 ) ) -RRB- cord-023095-4dannjjm 6245 19 in in IN cord-023095-4dannjjm 6245 20 horses horse NNS cord-023095-4dannjjm 6245 21 affected affect VBN cord-023095-4dannjjm 6245 22 with with IN cord-023095-4dannjjm 6245 23 recurrent recurrent JJ cord-023095-4dannjjm 6245 24 airway airway JJ cord-023095-4dannjjm 6245 25 obstruction obstruction NN cord-023095-4dannjjm 6245 26 ( ( -LRB- cord-023095-4dannjjm 6245 27 RAO RAO NNP cord-023095-4dannjjm 6245 28 ) ) -RRB- cord-023095-4dannjjm 6245 29 and and CC cord-023095-4dannjjm 6245 30 in in IN cord-023095-4dannjjm 6245 31 control control NN cord-023095-4dannjjm 6245 32 horses horse NNS cord-023095-4dannjjm 6245 33 using use VBG cord-023095-4dannjjm 6245 34 proteomics proteomic NNS cord-023095-4dannjjm 6245 35 and and CC cord-023095-4dannjjm 6245 36 Western western JJ cord-023095-4dannjjm 6245 37 blot blot NN cord-023095-4dannjjm 6245 38 techniques technique NNS cord-023095-4dannjjm 6245 39 . . . cord-023095-4dannjjm 6246 1 RAO RAO NNP cord-023095-4dannjjm 6246 2 - - HYPH cord-023095-4dannjjm 6246 3 affected affect VBN cord-023095-4dannjjm 6246 4 ( ( -LRB- cord-023095-4dannjjm 6246 5 n n NN cord-023095-4dannjjm 6246 6 5 5 CD cord-023095-4dannjjm 6246 7 5 5 CD cord-023095-4dannjjm 6246 8 ) ) -RRB- cord-023095-4dannjjm 6246 9 and and CC cord-023095-4dannjjm 6246 10 control control NN cord-023095-4dannjjm 6246 11 horses horse NNS cord-023095-4dannjjm 6246 12 ( ( -LRB- cord-023095-4dannjjm 6246 13 n n NN cord-023095-4dannjjm 6246 14 5 5 CD cord-023095-4dannjjm 6246 15 6 6 CD cord-023095-4dannjjm 6246 16 ) ) -RRB- cord-023095-4dannjjm 6246 17 were be VBD cord-023095-4dannjjm 6246 18 subjected subject VBN cord-023095-4dannjjm 6246 19 to to IN cord-023095-4dannjjm 6246 20 an an DT cord-023095-4dannjjm 6246 21 experimental experimental JJ cord-023095-4dannjjm 6246 22 exposure exposure NN cord-023095-4dannjjm 6246 23 trial trial NN cord-023095-4dannjjm 6246 24 ; ; : cord-023095-4dannjjm 6246 25 when when WRB cord-023095-4dannjjm 6246 26 the the DT cord-023095-4dannjjm 6246 27 RAO RAO NNP cord-023095-4dannjjm 6246 28 - - HYPH cord-023095-4dannjjm 6246 29 affected affect VBN cord-023095-4dannjjm 6246 30 horses horse NNS cord-023095-4dannjjm 6246 31 showed show VBD cord-023095-4dannjjm 6246 32 clinical clinical JJ cord-023095-4dannjjm 6246 33 signs sign NNS cord-023095-4dannjjm 6246 34 of of IN cord-023095-4dannjjm 6246 35 disease disease NN cord-023095-4dannjjm 6246 36 , , , cord-023095-4dannjjm 6246 37 BALF BALF NNP cord-023095-4dannjjm 6246 38 was be VBD cord-023095-4dannjjm 6246 39 collected collect VBN cord-023095-4dannjjm 6246 40 from from IN cord-023095-4dannjjm 6246 41 all all DT cord-023095-4dannjjm 6246 42 horses horse NNS cord-023095-4dannjjm 6246 43 . . . cord-023095-4dannjjm 6247 1 BALF BALF NNP cord-023095-4dannjjm 6247 2 was be VBD cord-023095-4dannjjm 6247 3 also also RB cord-023095-4dannjjm 6247 4 collected collect VBN cord-023095-4dannjjm 6247 5 from from IN cord-023095-4dannjjm 6247 6 client client NN cord-023095-4dannjjm 6247 7 - - HYPH cord-023095-4dannjjm 6247 8 owned own VBN cord-023095-4dannjjm 6247 9 RAO RAO NNP cord-023095-4dannjjm 6247 10 - - HYPH cord-023095-4dannjjm 6247 11 affected affect VBN cord-023095-4dannjjm 6247 12 horses horse NNS cord-023095-4dannjjm 6247 13 ( ( -LRB- cord-023095-4dannjjm 6247 14 n n NN cord-023095-4dannjjm 6247 15 5 5 CD cord-023095-4dannjjm 6247 16 15 15 CD cord-023095-4dannjjm 6247 17 ) ) -RRB- cord-023095-4dannjjm 6247 18 with with IN cord-023095-4dannjjm 6247 19 naturally naturally RB cord-023095-4dannjjm 6247 20 - - HYPH cord-023095-4dannjjm 6247 21 occurring occur VBG cord-023095-4dannjjm 6247 22 clinical clinical JJ cord-023095-4dannjjm 6247 23 signs sign NNS cord-023095-4dannjjm 6247 24 of of IN cord-023095-4dannjjm 6247 25 disease disease NN cord-023095-4dannjjm 6247 26 and and CC cord-023095-4dannjjm 6247 27 client client NN cord-023095-4dannjjm 6247 28 - - HYPH cord-023095-4dannjjm 6247 29 owned own VBN cord-023095-4dannjjm 6247 30 control control NN cord-023095-4dannjjm 6247 31 horses horse NNS cord-023095-4dannjjm 6247 32 ( ( -LRB- cord-023095-4dannjjm 6247 33 n n NN cord-023095-4dannjjm 6247 34 5 5 CD cord-023095-4dannjjm 6247 35 12 12 CD cord-023095-4dannjjm 6247 36 ) ) -RRB- cord-023095-4dannjjm 6247 37 from from IN cord-023095-4dannjjm 6247 38 the the DT cord-023095-4dannjjm 6247 39 same same JJ cord-023095-4dannjjm 6247 40 environments environment NNS cord-023095-4dannjjm 6247 41 . . . cord-023095-4dannjjm 6248 1 The the DT cord-023095-4dannjjm 6248 2 BALF BALF NNP cord-023095-4dannjjm 6248 3 from from IN cord-023095-4dannjjm 6248 4 the the DT cord-023095-4dannjjm 6248 5 experimental experimental JJ cord-023095-4dannjjm 6248 6 exposure exposure NN cord-023095-4dannjjm 6248 7 trial trial NN cord-023095-4dannjjm 6248 8 horses horse NNS cord-023095-4dannjjm 6248 9 was be VBD cord-023095-4dannjjm 6248 10 subjected subject VBN cord-023095-4dannjjm 6248 11 to to IN cord-023095-4dannjjm 6248 12 trypsin trypsin JJ cord-023095-4dannjjm 6248 13 digestion digestion NN cord-023095-4dannjjm 6248 14 and and CC cord-023095-4dannjjm 6248 15 proteomics proteomic NNS cord-023095-4dannjjm 6248 16 analysis analysis NN cord-023095-4dannjjm 6248 17 with with IN cord-023095-4dannjjm 6248 18 mass mass NN cord-023095-4dannjjm 6248 19 spectrometry spectrometry NNP cord-023095-4dannjjm 6248 20 ( ( -LRB- cord-023095-4dannjjm 6248 21 MS MS NNP cord-023095-4dannjjm 6248 22 ) ) -RRB- cord-023095-4dannjjm 6248 23 . . . cord-023095-4dannjjm 6249 1 Peaks peak NNS cord-023095-4dannjjm 6249 2 detected detect VBD cord-023095-4dannjjm 6249 3 with with IN cord-023095-4dannjjm 6249 4 MS MS NNP cord-023095-4dannjjm 6249 5 were be VBD cord-023095-4dannjjm 6249 6 identified identify VBN cord-023095-4dannjjm 6249 7 using use VBG cord-023095-4dannjjm 6249 8 tandem tandem JJ cord-023095-4dannjjm 6249 9 MS MS NNP cord-023095-4dannjjm 6249 10 analysis analysis NN cord-023095-4dannjjm 6249 11 and and CC cord-023095-4dannjjm 6249 12 database database NN cord-023095-4dannjjm 6249 13 searches search NNS cord-023095-4dannjjm 6249 14 . . . cord-023095-4dannjjm 6250 1 Western western JJ cord-023095-4dannjjm 6250 2 blot blot NN cord-023095-4dannjjm 6250 3 was be VBD cord-023095-4dannjjm 6250 4 used use VBN cord-023095-4dannjjm 6250 5 to to TO cord-023095-4dannjjm 6250 6 confirm confirm VB cord-023095-4dannjjm 6250 7 the the DT cord-023095-4dannjjm 6250 8 identity identity NN cord-023095-4dannjjm 6250 9 and and CC cord-023095-4dannjjm 6250 10 expression expression NN cord-023095-4dannjjm 6250 11 levels level NNS cord-023095-4dannjjm 6250 12 of of IN cord-023095-4dannjjm 6250 13 two two CD cord-023095-4dannjjm 6250 14 proteins protein NNS cord-023095-4dannjjm 6250 15 identified identify VBN cord-023095-4dannjjm 6250 16 using use VBG cord-023095-4dannjjm 6250 17 proteomics proteomic NNS cord-023095-4dannjjm 6250 18 techniques technique NNS cord-023095-4dannjjm 6250 19 in in IN cord-023095-4dannjjm 6250 20 the the DT cord-023095-4dannjjm 6250 21 BALF BALF NNP cord-023095-4dannjjm 6250 22 of of IN cord-023095-4dannjjm 6250 23 all all DT cord-023095-4dannjjm 6250 24 horses horse NNS cord-023095-4dannjjm 6250 25 . . . cord-023095-4dannjjm 6251 1 Data datum NNS cord-023095-4dannjjm 6251 2 from from IN cord-023095-4dannjjm 6251 3 MS MS NNP cord-023095-4dannjjm 6251 4 experiments experiment NNS cord-023095-4dannjjm 6251 5 were be VBD cord-023095-4dannjjm 6251 6 analyzed analyze VBN cord-023095-4dannjjm 6251 7 with with IN cord-023095-4dannjjm 6251 8 the the DT cord-023095-4dannjjm 6251 9 Student Student NNP cord-023095-4dannjjm 6251 10 's 's POS cord-023095-4dannjjm 6251 11 t t NN cord-023095-4dannjjm 6251 12 - - HYPH cord-023095-4dannjjm 6251 13 test test NN cord-023095-4dannjjm 6251 14 to to TO cord-023095-4dannjjm 6251 15 compare compare VB cord-023095-4dannjjm 6251 16 peak peak NN cord-023095-4dannjjm 6251 17 intensity intensity NN cord-023095-4dannjjm 6251 18 between between IN cord-023095-4dannjjm 6251 19 RAO RAO NNP cord-023095-4dannjjm 6251 20 - - HYPH cord-023095-4dannjjm 6251 21 affected affect VBN cord-023095-4dannjjm 6251 22 and and CC cord-023095-4dannjjm 6251 23 control control NN cord-023095-4dannjjm 6251 24 horses horse NNS cord-023095-4dannjjm 6251 25 . . . cord-023095-4dannjjm 6252 1 Western western JJ cord-023095-4dannjjm 6252 2 blot blot NN cord-023095-4dannjjm 6252 3 band band NN cord-023095-4dannjjm 6252 4 density density NN cord-023095-4dannjjm 6252 5 data datum NNS cord-023095-4dannjjm 6252 6 was be VBD cord-023095-4dannjjm 6252 7 analyzed analyze VBN cord-023095-4dannjjm 6252 8 with with IN cord-023095-4dannjjm 6252 9 the the DT cord-023095-4dannjjm 6252 10 Kruskal Kruskal NNP cord-023095-4dannjjm 6252 11 - - HYPH cord-023095-4dannjjm 6252 12 Wallis Wallis NNP cord-023095-4dannjjm 6252 13 ANOVA ANOVA NNP cord-023095-4dannjjm 6252 14 for for IN cord-023095-4dannjjm 6252 15 comparison comparison NN cord-023095-4dannjjm 6252 16 between between IN cord-023095-4dannjjm 6252 17 groups group NNS cord-023095-4dannjjm 6252 18 of of IN cord-023095-4dannjjm 6252 19 horses horse NNS cord-023095-4dannjjm 6252 20 . . . cord-023095-4dannjjm 6253 1 Significance significance NN cord-023095-4dannjjm 6253 2 level level NN cord-023095-4dannjjm 6253 3 was be VBD cord-023095-4dannjjm 6253 4 set set VBN cord-023095-4dannjjm 6253 5 at at IN cord-023095-4dannjjm 6253 6 P p NN cord-023095-4dannjjm 6253 7 o o NN cord-023095-4dannjjm 6253 8 0.05 0.05 CD cord-023095-4dannjjm 6253 9 . . . cord-023095-4dannjjm 6254 1 With with IN cord-023095-4dannjjm 6254 2 MS MS NNP cord-023095-4dannjjm 6254 3 proteomic proteomic JJ cord-023095-4dannjjm 6254 4 analysis analysis NN cord-023095-4dannjjm 6254 5 of of IN cord-023095-4dannjjm 6254 6 the the DT cord-023095-4dannjjm 6254 7 BALF BALF NNP cord-023095-4dannjjm 6254 8 from from IN cord-023095-4dannjjm 6254 9 the the DT cord-023095-4dannjjm 6254 10 experimental experimental JJ cord-023095-4dannjjm 6254 11 exposure exposure NN cord-023095-4dannjjm 6254 12 trial trial NN cord-023095-4dannjjm 6254 13 horses horse NNS cord-023095-4dannjjm 6254 14 , , , cord-023095-4dannjjm 6254 15 2049 2049 CD cord-023095-4dannjjm 6254 16 total total JJ cord-023095-4dannjjm 6254 17 peaks peak NNS cord-023095-4dannjjm 6254 18 ( ( -LRB- cord-023095-4dannjjm 6254 19 peptides peptide NNS cord-023095-4dannjjm 6254 20 ) ) -RRB- cord-023095-4dannjjm 6254 21 were be VBD cord-023095-4dannjjm 6254 22 identified identify VBN cord-023095-4dannjjm 6254 23 . . . cord-023095-4dannjjm 6255 1 Of of IN cord-023095-4dannjjm 6255 2 these these DT cord-023095-4dannjjm 6255 3 peaks peak NNS cord-023095-4dannjjm 6255 4 , , , cord-023095-4dannjjm 6255 5 100 100 CD cord-023095-4dannjjm 6255 6 were be VBD cord-023095-4dannjjm 6255 7 differentially differentially RB cord-023095-4dannjjm 6255 8 expressed express VBN cord-023095-4dannjjm 6255 9 between between IN cord-023095-4dannjjm 6255 10 the the DT cord-023095-4dannjjm 6255 11 RAO RAO NNP cord-023095-4dannjjm 6255 12 - - HYPH cord-023095-4dannjjm 6255 13 affected affect VBN cord-023095-4dannjjm 6255 14 ( ( -LRB- cord-023095-4dannjjm 6255 15 24 24 CD cord-023095-4dannjjm 6255 16 over over RB cord-023095-4dannjjm 6255 17 - - HYPH cord-023095-4dannjjm 6255 18 expressed express VBN cord-023095-4dannjjm 6255 19 ) ) -RRB- cord-023095-4dannjjm 6255 20 and and CC cord-023095-4dannjjm 6255 21 control control NN cord-023095-4dannjjm 6255 22 horses horse NNS cord-023095-4dannjjm 6255 23 ( ( -LRB- cord-023095-4dannjjm 6255 24 76 76 CD cord-023095-4dannjjm 6255 25 over over RB cord-023095-4dannjjm 6255 26 - - HYPH cord-023095-4dannjjm 6255 27 expressed express VBN cord-023095-4dannjjm 6255 28 ) ) -RRB- cord-023095-4dannjjm 6255 29 . . . cord-023095-4dannjjm 6256 1 Identifications identification NNS cord-023095-4dannjjm 6256 2 were be VBD cord-023095-4dannjjm 6256 3 made make VBN cord-023095-4dannjjm 6256 4 for for IN cord-023095-4dannjjm 6256 5 250 250 CD cord-023095-4dannjjm 6256 6 BALF BALF NNP cord-023095-4dannjjm 6256 7 proteins protein NNS cord-023095-4dannjjm 6256 8 . . . cord-023095-4dannjjm 6257 1 Transferrin Transferrin NNP cord-023095-4dannjjm 6257 2 and and CC cord-023095-4dannjjm 6257 3 secretoglobin secretoglobin NNP cord-023095-4dannjjm 6257 4 were be VBD cord-023095-4dannjjm 6257 5 chosen choose VBN cord-023095-4dannjjm 6257 6 for for IN cord-023095-4dannjjm 6257 7 validation validation NN cord-023095-4dannjjm 6257 8 with with IN cord-023095-4dannjjm 6257 9 Western western JJ cord-023095-4dannjjm 6257 10 blot blot NN cord-023095-4dannjjm 6257 11 . . . cord-023095-4dannjjm 6258 1 Proteomics Proteomics NNP cord-023095-4dannjjm 6258 2 indicated indicate VBD cord-023095-4dannjjm 6258 3 that that IN cord-023095-4dannjjm 6258 4 secretoglobin secretoglobin NNP cord-023095-4dannjjm 6258 5 was be VBD cord-023095-4dannjjm 6258 6 not not RB cord-023095-4dannjjm 6258 7 differentially differentially RB cord-023095-4dannjjm 6258 8 expressed express VBN cord-023095-4dannjjm 6258 9 between between IN cord-023095-4dannjjm 6258 10 the the DT cord-023095-4dannjjm 6258 11 experimental experimental JJ cord-023095-4dannjjm 6258 12 exposure exposure NN cord-023095-4dannjjm 6258 13 trial trial NN cord-023095-4dannjjm 6258 14 group group NN cord-023095-4dannjjm 6258 15 ; ; : cord-023095-4dannjjm 6258 16 this this DT cord-023095-4dannjjm 6258 17 was be VBD cord-023095-4dannjjm 6258 18 confirmed confirm VBN cord-023095-4dannjjm 6258 19 with with IN cord-023095-4dannjjm 6258 20 Western western JJ cord-023095-4dannjjm 6258 21 blot blot NN cord-023095-4dannjjm 6258 22 analysis analysis NN cord-023095-4dannjjm 6258 23 . . . cord-023095-4dannjjm 6259 1 Western western JJ cord-023095-4dannjjm 6259 2 blot blot NN cord-023095-4dannjjm 6259 3 also also RB cord-023095-4dannjjm 6259 4 showed show VBD cord-023095-4dannjjm 6259 5 that that IN cord-023095-4dannjjm 6259 6 clientowned clientowne VBN cord-023095-4dannjjm 6259 7 RAO RAO NNP cord-023095-4dannjjm 6259 8 - - HYPH cord-023095-4dannjjm 6259 9 affected affect VBN cord-023095-4dannjjm 6259 10 horses horse NNS cord-023095-4dannjjm 6259 11 had have VBD cord-023095-4dannjjm 6259 12 lower low JJR cord-023095-4dannjjm 6259 13 secretoglobin secretoglobin NNP cord-023095-4dannjjm 6259 14 expression expression NN cord-023095-4dannjjm 6259 15 than than IN cord-023095-4dannjjm 6259 16 client client NN cord-023095-4dannjjm 6259 17 - - HYPH cord-023095-4dannjjm 6259 18 owned own VBN cord-023095-4dannjjm 6259 19 control control NN cord-023095-4dannjjm 6259 20 horses horse NNS cord-023095-4dannjjm 6259 21 and and CC cord-023095-4dannjjm 6259 22 control control NN cord-023095-4dannjjm 6259 23 horses horse NNS cord-023095-4dannjjm 6259 24 before before IN cord-023095-4dannjjm 6259 25 experimental experimental JJ cord-023095-4dannjjm 6259 26 exposure exposure NN cord-023095-4dannjjm 6259 27 . . . cord-023095-4dannjjm 6260 1 According accord VBG cord-023095-4dannjjm 6260 2 to to IN cord-023095-4dannjjm 6260 3 the the DT cord-023095-4dannjjm 6260 4 proteomics proteomic NNS cord-023095-4dannjjm 6260 5 data datum NNS cord-023095-4dannjjm 6260 6 , , , cord-023095-4dannjjm 6260 7 transferrin transferrin NN cord-023095-4dannjjm 6260 8 was be VBD cord-023095-4dannjjm 6260 9 over over RB cord-023095-4dannjjm 6260 10 - - HYPH cord-023095-4dannjjm 6260 11 expressed express VBN cord-023095-4dannjjm 6260 12 in in IN cord-023095-4dannjjm 6260 13 control control NN cord-023095-4dannjjm 6260 14 horses horse NNS cord-023095-4dannjjm 6260 15 after after IN cord-023095-4dannjjm 6260 16 experimental experimental JJ cord-023095-4dannjjm 6260 17 exposure exposure NN cord-023095-4dannjjm 6260 18 compared compare VBN cord-023095-4dannjjm 6260 19 to to IN cord-023095-4dannjjm 6260 20 RAO RAO NNP cord-023095-4dannjjm 6260 21 - - HYPH cord-023095-4dannjjm 6260 22 affected affect VBN cord-023095-4dannjjm 6260 23 horses horse NNS cord-023095-4dannjjm 6260 24 . . . cord-023095-4dannjjm 6261 1 While while IN cord-023095-4dannjjm 6261 2 the the DT cord-023095-4dannjjm 6261 3 Western western JJ cord-023095-4dannjjm 6261 4 blot blot NN cord-023095-4dannjjm 6261 5 analysis analysis NN cord-023095-4dannjjm 6261 6 did do VBD cord-023095-4dannjjm 6261 7 not not RB cord-023095-4dannjjm 6261 8 show show VB cord-023095-4dannjjm 6261 9 a a DT cord-023095-4dannjjm 6261 10 statistically statistically RB cord-023095-4dannjjm 6261 11 significant significant JJ cord-023095-4dannjjm 6261 12 difference difference NN cord-023095-4dannjjm 6261 13 in in IN cord-023095-4dannjjm 6261 14 this this DT cord-023095-4dannjjm 6261 15 comparison comparison NN cord-023095-4dannjjm 6261 16 , , , cord-023095-4dannjjm 6261 17 transferrin transferrin NN cord-023095-4dannjjm 6261 18 was be VBD cord-023095-4dannjjm 6261 19 significantly significantly RB cord-023095-4dannjjm 6261 20 over over RB cord-023095-4dannjjm 6261 21 - - HYPH cord-023095-4dannjjm 6261 22 expressed express VBN cord-023095-4dannjjm 6261 23 in in IN cord-023095-4dannjjm 6261 24 control control NN cord-023095-4dannjjm 6261 25 horses horse NNS cord-023095-4dannjjm 6261 26 before before IN cord-023095-4dannjjm 6261 27 experimental experimental JJ cord-023095-4dannjjm 6261 28 exposure exposure NN cord-023095-4dannjjm 6261 29 compared compare VBN cord-023095-4dannjjm 6261 30 to to IN cord-023095-4dannjjm 6261 31 client client NN cord-023095-4dannjjm 6261 32 - - HYPH cord-023095-4dannjjm 6261 33 owned own VBN cord-023095-4dannjjm 6261 34 RAO RAO NNP cord-023095-4dannjjm 6261 35 - - HYPH cord-023095-4dannjjm 6261 36 affected affect VBN cord-023095-4dannjjm 6261 37 horses horse NNS cord-023095-4dannjjm 6261 38 . . . cord-023095-4dannjjm 6262 1 In in IN cord-023095-4dannjjm 6262 2 addition addition NN cord-023095-4dannjjm 6262 3 , , , cord-023095-4dannjjm 6262 4 both both CC cord-023095-4dannjjm 6262 5 secretoglobin secretoglobin NNP cord-023095-4dannjjm 6262 6 and and CC cord-023095-4dannjjm 6262 7 transferrin transferrin NN cord-023095-4dannjjm 6262 8 band band NN cord-023095-4dannjjm 6262 9 densities density NNS cord-023095-4dannjjm 6262 10 on on IN cord-023095-4dannjjm 6262 11 Western western JJ cord-023095-4dannjjm 6262 12 blot blot NN cord-023095-4dannjjm 6262 13 were be VBD cord-023095-4dannjjm 6262 14 negatively negatively RB cord-023095-4dannjjm 6262 15 correlated correlate VBN cord-023095-4dannjjm 6262 16 with with IN cord-023095-4dannjjm 6262 17 airway airway JJ cord-023095-4dannjjm 6262 18 obstruction obstruction NN cord-023095-4dannjjm 6262 19 and and CC cord-023095-4dannjjm 6262 20 neutrophilic neutrophilic JJ cord-023095-4dannjjm 6262 21 pulmonary pulmonary JJ cord-023095-4dannjjm 6262 22 inflammation inflammation NN cord-023095-4dannjjm 6262 23 . . . cord-023095-4dannjjm 6263 1 This this DT cord-023095-4dannjjm 6263 2 study study NN cord-023095-4dannjjm 6263 3 demonstrates demonstrate VBZ cord-023095-4dannjjm 6263 4 that that IN cord-023095-4dannjjm 6263 5 proteomics proteomic NNS cord-023095-4dannjjm 6263 6 techniques technique NNS cord-023095-4dannjjm 6263 7 can can MD cord-023095-4dannjjm 6263 8 be be VB cord-023095-4dannjjm 6263 9 used use VBN cord-023095-4dannjjm 6263 10 in in IN cord-023095-4dannjjm 6263 11 the the DT cord-023095-4dannjjm 6263 12 investigation investigation NN cord-023095-4dannjjm 6263 13 of of IN cord-023095-4dannjjm 6263 14 equine equine JJ cord-023095-4dannjjm 6263 15 BALF BALF NNP cord-023095-4dannjjm 6263 16 proteins protein NNS cord-023095-4dannjjm 6263 17 . . . cord-023095-4dannjjm 6264 1 The the DT cord-023095-4dannjjm 6264 2 proteins protein NNS cord-023095-4dannjjm 6264 3 identified identify VBN cord-023095-4dannjjm 6264 4 as as IN cord-023095-4dannjjm 6264 5 differentially differentially RB cord-023095-4dannjjm 6264 6 expressed express VBN cord-023095-4dannjjm 6264 7 between between IN cord-023095-4dannjjm 6264 8 RAO RAO NNP cord-023095-4dannjjm 6264 9 - - HYPH cord-023095-4dannjjm 6264 10 affected affect VBN cord-023095-4dannjjm 6264 11 and and CC cord-023095-4dannjjm 6264 12 control control NN cord-023095-4dannjjm 6264 13 horses horse NNS cord-023095-4dannjjm 6264 14 in in IN cord-023095-4dannjjm 6264 15 this this DT cord-023095-4dannjjm 6264 16 study study NN cord-023095-4dannjjm 6264 17 including include VBG cord-023095-4dannjjm 6264 18 , , , cord-023095-4dannjjm 6264 19 but but CC cord-023095-4dannjjm 6264 20 not not RB cord-023095-4dannjjm 6264 21 limited limited JJ cord-023095-4dannjjm 6264 22 to to IN cord-023095-4dannjjm 6264 23 , , , cord-023095-4dannjjm 6264 24 secretoglobin secretoglobin NNP cord-023095-4dannjjm 6264 25 and and CC cord-023095-4dannjjm 6264 26 transferrin transferrin NN cord-023095-4dannjjm 6264 27 should should MD cord-023095-4dannjjm 6264 28 undergo undergo VB cord-023095-4dannjjm 6264 29 further further JJ cord-023095-4dannjjm 6264 30 evaluation evaluation NN cord-023095-4dannjjm 6264 31 for for IN cord-023095-4dannjjm 6264 32 their -PRON- PRP$ cord-023095-4dannjjm 6264 33 use use NN cord-023095-4dannjjm 6264 34 as as IN cord-023095-4dannjjm 6264 35 biomarkers biomarker NNS cord-023095-4dannjjm 6264 36 of of IN cord-023095-4dannjjm 6264 37 RAO RAO NNP cord-023095-4dannjjm 6264 38 , , , cord-023095-4dannjjm 6264 39 and and CC cord-023095-4dannjjm 6264 40 as as IN cord-023095-4dannjjm 6264 41 potential potential JJ cord-023095-4dannjjm 6264 42 targets target NNS cord-023095-4dannjjm 6264 43 of of IN cord-023095-4dannjjm 6264 44 new new JJ cord-023095-4dannjjm 6264 45 therapeutic therapeutic JJ cord-023095-4dannjjm 6264 46 agents agent NNS cord-023095-4dannjjm 6264 47 for for IN cord-023095-4dannjjm 6264 48 RAO RAO NNP cord-023095-4dannjjm 6264 49 . . . cord-023095-4dannjjm 6265 1 Cardiotoxic cardiotoxic JJ cord-023095-4dannjjm 6265 2 effects effect NNS cord-023095-4dannjjm 6265 3 of of IN cord-023095-4dannjjm 6265 4 rattlesnake rattlesnake NN cord-023095-4dannjjm 6265 5 venom venom NN cord-023095-4dannjjm 6265 6 in in IN cord-023095-4dannjjm 6265 7 the the DT cord-023095-4dannjjm 6265 8 horse horse NN cord-023095-4dannjjm 6265 9 are be VBP cord-023095-4dannjjm 6265 10 not not RB cord-023095-4dannjjm 6265 11 well well RB cord-023095-4dannjjm 6265 12 defined define VBN cord-023095-4dannjjm 6265 13 . . . cord-023095-4dannjjm 6266 1 The the DT cord-023095-4dannjjm 6266 2 first first JJ cord-023095-4dannjjm 6266 3 aim aim NN cord-023095-4dannjjm 6266 4 of of IN cord-023095-4dannjjm 6266 5 this this DT cord-023095-4dannjjm 6266 6 study study NN cord-023095-4dannjjm 6266 7 was be VBD cord-023095-4dannjjm 6266 8 to to TO cord-023095-4dannjjm 6266 9 document document VB cord-023095-4dannjjm 6266 10 cardiac cardiac JJ cord-023095-4dannjjm 6266 11 damage damage NN cord-023095-4dannjjm 6266 12 in in IN cord-023095-4dannjjm 6266 13 naturally naturally RB cord-023095-4dannjjm 6266 14 envenomated envenomate VBN cord-023095-4dannjjm 6266 15 horses horse NNS cord-023095-4dannjjm 6266 16 . . . cord-023095-4dannjjm 6267 1 Twenty twenty CD cord-023095-4dannjjm 6267 2 horses horse NNS cord-023095-4dannjjm 6267 3 with with IN cord-023095-4dannjjm 6267 4 clinical clinical JJ cord-023095-4dannjjm 6267 5 diagnosis diagnosis NN cord-023095-4dannjjm 6267 6 of of IN cord-023095-4dannjjm 6267 7 snake snake NN cord-023095-4dannjjm 6267 8 bite bite NN cord-023095-4dannjjm 6267 9 were be VBD cord-023095-4dannjjm 6267 10 included include VBN cord-023095-4dannjjm 6267 11 . . . cord-023095-4dannjjm 6268 1 A a DT cord-023095-4dannjjm 6268 2 snake snake NN cord-023095-4dannjjm 6268 3 venom venom NN cord-023095-4dannjjm 6268 4 ELISA ELISA NNP cord-023095-4dannjjm 6268 5 was be VBD cord-023095-4dannjjm 6268 6 utilized utilize VBN cord-023095-4dannjjm 6268 7 to to TO cord-023095-4dannjjm 6268 8 confirm confirm VB cord-023095-4dannjjm 6268 9 envenomation envenomation NN cord-023095-4dannjjm 6268 10 when when WRB cord-023095-4dannjjm 6268 11 possible possible JJ cord-023095-4dannjjm 6268 12 . . . cord-023095-4dannjjm 6269 1 Serum serum NN cord-023095-4dannjjm 6269 2 and and CC cord-023095-4dannjjm 6269 3 plasma plasma NN cord-023095-4dannjjm 6269 4 were be VBD cord-023095-4dannjjm 6269 5 collected collect VBN cord-023095-4dannjjm 6269 6 at at IN cord-023095-4dannjjm 6269 7 selected select VBN cord-023095-4dannjjm 6269 8 intervals interval NNS cord-023095-4dannjjm 6269 9 . . . cord-023095-4dannjjm 6270 1 Plasma plasma NN cord-023095-4dannjjm 6270 2 was be VBD cord-023095-4dannjjm 6270 3 assayed assay VBN cord-023095-4dannjjm 6270 4 for for IN cord-023095-4dannjjm 6270 5 cardiac cardiac NN cord-023095-4dannjjm 6270 6 troponin troponin JJ cord-023095-4dannjjm 6270 7 I -PRON- PRP cord-023095-4dannjjm 6270 8 ( ( -LRB- cord-023095-4dannjjm 6270 9 cTnI cTnI NNP cord-023095-4dannjjm 6270 10 ) ) -RRB- cord-023095-4dannjjm 6270 11 using use VBG cord-023095-4dannjjm 6270 12 a a DT cord-023095-4dannjjm 6270 13 flurometric flurometric JJ cord-023095-4dannjjm 6270 14 assay assay NN cord-023095-4dannjjm 6270 15 ( ( -LRB- cord-023095-4dannjjm 6270 16 Stratus Stratus NNP cord-023095-4dannjjm 6270 17 CS CS NNP cord-023095-4dannjjm 6270 18 s s NNP cord-023095-4dannjjm 6270 19 , , , cord-023095-4dannjjm 6270 20 Dade Dade NNP cord-023095-4dannjjm 6270 21 Behring Behring NNP cord-023095-4dannjjm 6270 22 ) ) -RRB- cord-023095-4dannjjm 6270 23 . . . cord-023095-4dannjjm 6271 1 Holter holter NN cord-023095-4dannjjm 6271 2 monitors monitor NNS cord-023095-4dannjjm 6271 3 ( ( -LRB- cord-023095-4dannjjm 6271 4 Zymed Zymed NNP cord-023095-4dannjjm 6271 5 s s NNP cord-023095-4dannjjm 6271 6 , , , cord-023095-4dannjjm 6271 7 Philips Philips NNP cord-023095-4dannjjm 6271 8 ) ) -RRB- cord-023095-4dannjjm 6271 9 were be VBD cord-023095-4dannjjm 6271 10 placed place VBN cord-023095-4dannjjm 6271 11 at at IN cord-023095-4dannjjm 6271 12 admission admission NN cord-023095-4dannjjm 6271 13 , , , cord-023095-4dannjjm 6271 14 1 1 CD cord-023095-4dannjjm 6271 15 week week NN cord-023095-4dannjjm 6271 16 and and CC cord-023095-4dannjjm 6271 17 1 1 CD cord-023095-4dannjjm 6271 18 month month NN cord-023095-4dannjjm 6271 19 post post NN cord-023095-4dannjjm 6271 20 presentation presentation NN cord-023095-4dannjjm 6271 21 . . . cord-023095-4dannjjm 6272 1 Echocardiography echocardiography NN cord-023095-4dannjjm 6272 2 was be VBD cord-023095-4dannjjm 6272 3 performed perform VBN cord-023095-4dannjjm 6272 4 on on IN cord-023095-4dannjjm 6272 5 available available JJ cord-023095-4dannjjm 6272 6 horses horse NNS cord-023095-4dannjjm 6272 7 5 5 CD cord-023095-4dannjjm 6272 8 - - SYM cord-023095-4dannjjm 6272 9 7 7 CD cord-023095-4dannjjm 6272 10 months month NNS cord-023095-4dannjjm 6272 11 after after IN cord-023095-4dannjjm 6272 12 envenomation envenomation NN cord-023095-4dannjjm 6272 13 . . . cord-023095-4dannjjm 6273 1 The the DT cord-023095-4dannjjm 6273 2 second second JJ cord-023095-4dannjjm 6273 3 aim aim NN cord-023095-4dannjjm 6273 4 of of IN cord-023095-4dannjjm 6273 5 this this DT cord-023095-4dannjjm 6273 6 study study NN cord-023095-4dannjjm 6273 7 was be VBD cord-023095-4dannjjm 6273 8 to to TO cord-023095-4dannjjm 6273 9 investigate investigate VB cord-023095-4dannjjm 6273 10 potential potential JJ cord-023095-4dannjjm 6273 11 mechanisms mechanism NNS cord-023095-4dannjjm 6273 12 of of IN cord-023095-4dannjjm 6273 13 the the DT cord-023095-4dannjjm 6273 14 cardiac cardiac JJ cord-023095-4dannjjm 6273 15 damage damage NN cord-023095-4dannjjm 6273 16 . . . cord-023095-4dannjjm 6274 1 Serum serum NN cord-023095-4dannjjm 6274 2 samples sample NNS cord-023095-4dannjjm 6274 3 were be VBD cord-023095-4dannjjm 6274 4 assayed assay VBN cord-023095-4dannjjm 6274 5 for for IN cord-023095-4dannjjm 6274 6 TNFalpha TNFalpha NNS cord-023095-4dannjjm 6274 7 using use VBG cord-023095-4dannjjm 6274 8 a a DT cord-023095-4dannjjm 6274 9 commercial commercial JJ cord-023095-4dannjjm 6274 10 assay assay NN cord-023095-4dannjjm 6274 11 ( ( -LRB- cord-023095-4dannjjm 6274 12 Endogen Endogen NNP cord-023095-4dannjjm 6274 13 ) ) -RRB- cord-023095-4dannjjm 6274 14 . . . cord-023095-4dannjjm 6275 1 Antibody antibody NN cord-023095-4dannjjm 6275 2 titers titer NNS cord-023095-4dannjjm 6275 3 to to IN cord-023095-4dannjjm 6275 4 Crotalus Crotalus NNP cord-023095-4dannjjm 6275 5 atrox atrox NN cord-023095-4dannjjm 6275 6 venom venom NN cord-023095-4dannjjm 6275 7 were be VBD cord-023095-4dannjjm 6275 8 measured measure VBN cord-023095-4dannjjm 6275 9 at at IN cord-023095-4dannjjm 6275 10 admission admission NN cord-023095-4dannjjm 6275 11 , , , cord-023095-4dannjjm 6275 12 1 1 CD cord-023095-4dannjjm 6275 13 week week NN cord-023095-4dannjjm 6275 14 and and CC cord-023095-4dannjjm 6276 1 1 1 CD cord-023095-4dannjjm 6276 2 month month NN cord-023095-4dannjjm 6276 3 after after IN cord-023095-4dannjjm 6276 4 natural natural JJ cord-023095-4dannjjm 6276 5 envenomation envenomation NN cord-023095-4dannjjm 6276 6 and and CC cord-023095-4dannjjm 6276 7 compared compare VBN cord-023095-4dannjjm 6276 8 to to IN cord-023095-4dannjjm 6276 9 titers titer NNS cord-023095-4dannjjm 6276 10 in in IN cord-023095-4dannjjm 6276 11 vaccinated vaccinated JJ cord-023095-4dannjjm 6276 12 horses horse NNS cord-023095-4dannjjm 6276 13 ( ( -LRB- cord-023095-4dannjjm 6276 14 Crotalus Crotalus NNP cord-023095-4dannjjm 6276 15 Atrox Atrox NNP cord-023095-4dannjjm 6276 16 Toxoid Toxoid NNP cord-023095-4dannjjm 6276 17 , , , cord-023095-4dannjjm 6276 18 Red Red NNP cord-023095-4dannjjm 6276 19 Rock Rock NNP cord-023095-4dannjjm 6276 20 Biologics Biologics NNPS cord-023095-4dannjjm 6276 21 ) ) -RRB- cord-023095-4dannjjm 6276 22 . . . cord-023095-4dannjjm 6277 1 A a DT cord-023095-4dannjjm 6277 2 significant significant JJ cord-023095-4dannjjm 6277 3 number number NN cord-023095-4dannjjm 6277 4 of of IN cord-023095-4dannjjm 6277 5 horses horse NNS cord-023095-4dannjjm 6277 6 showed show VBD cord-023095-4dannjjm 6277 7 elevations elevation NNS cord-023095-4dannjjm 6277 8 in in IN cord-023095-4dannjjm 6277 9 cTnI cTnI NNP cord-023095-4dannjjm 6277 10 ( ( -LRB- cord-023095-4dannjjm 6277 11 p p NN cord-023095-4dannjjm 6277 12 o o NN cord-023095-4dannjjm 6277 13 0.05 0.05 CD cord-023095-4dannjjm 6277 14 ) ) -RRB- cord-023095-4dannjjm 6277 15 at at IN cord-023095-4dannjjm 6277 16 one one CD cord-023095-4dannjjm 6277 17 or or CC cord-023095-4dannjjm 6277 18 more more JJR cord-023095-4dannjjm 6277 19 time time NN cord-023095-4dannjjm 6277 20 point point NN cord-023095-4dannjjm 6277 21 indicating indicate VBG cord-023095-4dannjjm 6277 22 myocardial myocardial JJ cord-023095-4dannjjm 6277 23 damage damage NN cord-023095-4dannjjm 6277 24 . . . cord-023095-4dannjjm 6278 1 Holter Holter NNP cord-023095-4dannjjm 6278 2 readings reading NNS cord-023095-4dannjjm 6278 3 revealed reveal VBD cord-023095-4dannjjm 6278 4 the the DT cord-023095-4dannjjm 6278 5 presence presence NN cord-023095-4dannjjm 6278 6 of of IN cord-023095-4dannjjm 6278 7 arrhythmias arrhythmias JJ cord-023095-4dannjjm 6278 8 or or CC cord-023095-4dannjjm 6278 9 persistent persistent JJ cord-023095-4dannjjm 6278 10 tachycardia tachycardia NN cord-023095-4dannjjm 6278 11 in in IN cord-023095-4dannjjm 6278 12 19 19 CD cord-023095-4dannjjm 6278 13 horses horse NNS cord-023095-4dannjjm 6278 14 . . . cord-023095-4dannjjm 6279 1 Five five CD cord-023095-4dannjjm 6279 2 of of IN cord-023095-4dannjjm 6279 3 twenty twenty CD cord-023095-4dannjjm 6279 4 horses horse NNS cord-023095-4dannjjm 6279 5 were be VBD cord-023095-4dannjjm 6279 6 available available JJ cord-023095-4dannjjm 6279 7 for for IN cord-023095-4dannjjm 6279 8 echocardiography echocardiography NN cord-023095-4dannjjm 6279 9 ; ; : cord-023095-4dannjjm 6279 10 no no DT cord-023095-4dannjjm 6279 11 abnormalities abnormality NNS cord-023095-4dannjjm 6279 12 were be VBD cord-023095-4dannjjm 6279 13 noted note VBN cord-023095-4dannjjm 6279 14 . . . cord-023095-4dannjjm 6280 1 Horses horse NNS cord-023095-4dannjjm 6280 2 with with IN cord-023095-4dannjjm 6280 3 increased increase VBN cord-023095-4dannjjm 6280 4 cTnI cTnI NNP cord-023095-4dannjjm 6280 5 tended tend VBD cord-023095-4dannjjm 6280 6 to to TO cord-023095-4dannjjm 6280 7 have have VB cord-023095-4dannjjm 6280 8 greater great JJR cord-023095-4dannjjm 6280 9 TNFalpha TNFalpha NNS cord-023095-4dannjjm 6280 10 concentrations concentration NNS cord-023095-4dannjjm 6280 11 compared compare VBN cord-023095-4dannjjm 6280 12 with with IN cord-023095-4dannjjm 6280 13 horses horse NNS cord-023095-4dannjjm 6280 14 without without IN cord-023095-4dannjjm 6280 15 increased increase VBN cord-023095-4dannjjm 6280 16 cTnI. cTnI. '' cord-023095-4dannjjm 6280 17 Peak peak NN cord-023095-4dannjjm 6280 18 venom venom NN cord-023095-4dannjjm 6280 19 titers titer NNS cord-023095-4dannjjm 6280 20 in in IN cord-023095-4dannjjm 6280 21 bitten bite VBN cord-023095-4dannjjm 6280 22 horses horse NNS cord-023095-4dannjjm 6280 23 were be VBD cord-023095-4dannjjm 6280 24 significantly significantly RB cord-023095-4dannjjm 6280 25 higher high JJR cord-023095-4dannjjm 6280 26 than than IN cord-023095-4dannjjm 6280 27 peak peak NN cord-023095-4dannjjm 6280 28 titers titer NNS cord-023095-4dannjjm 6280 29 in in IN cord-023095-4dannjjm 6280 30 vaccinated vaccinated JJ cord-023095-4dannjjm 6280 31 horses horse NNS cord-023095-4dannjjm 6280 32 ( ( -LRB- cord-023095-4dannjjm 6280 33 p p NN cord-023095-4dannjjm 6280 34 o o NN cord-023095-4dannjjm 6280 35 0.05 0.05 CD cord-023095-4dannjjm 6280 36 ) ) -RRB- cord-023095-4dannjjm 6280 37 . . . cord-023095-4dannjjm 6281 1 Rattlesnake rattlesnake NN cord-023095-4dannjjm 6281 2 envenomation envenomation NN cord-023095-4dannjjm 6281 3 was be VBD cord-023095-4dannjjm 6281 4 associated associate VBN cord-023095-4dannjjm 6281 5 with with IN cord-023095-4dannjjm 6281 6 evidence evidence NN cord-023095-4dannjjm 6281 7 of of IN cord-023095-4dannjjm 6281 8 cardiac cardiac JJ cord-023095-4dannjjm 6281 9 damage damage NN cord-023095-4dannjjm 6281 10 in in IN cord-023095-4dannjjm 6281 11 a a DT cord-023095-4dannjjm 6281 12 significant significant JJ cord-023095-4dannjjm 6281 13 proportion proportion NN cord-023095-4dannjjm 6281 14 of of IN cord-023095-4dannjjm 6281 15 bitten bite VBN cord-023095-4dannjjm 6281 16 horses horse NNS cord-023095-4dannjjm 6281 17 . . . cord-023095-4dannjjm 6282 1 Further further JJ cord-023095-4dannjjm 6282 2 studies study NNS cord-023095-4dannjjm 6282 3 are be VBP cord-023095-4dannjjm 6282 4 needed need VBN cord-023095-4dannjjm 6282 5 to to TO cord-023095-4dannjjm 6282 6 determine determine VB cord-023095-4dannjjm 6282 7 the the DT cord-023095-4dannjjm 6282 8 cause cause NN cord-023095-4dannjjm 6282 9 as as RB cord-023095-4dannjjm 6282 10 well well RB cord-023095-4dannjjm 6282 11 as as IN cord-023095-4dannjjm 6282 12 mechanisms mechanism NNS cord-023095-4dannjjm 6282 13 to to TO cord-023095-4dannjjm 6282 14 treat treat VB cord-023095-4dannjjm 6282 15 and/or and/or CC cord-023095-4dannjjm 6282 16 prevent prevent VB cord-023095-4dannjjm 6282 17 its -PRON- PRP$ cord-023095-4dannjjm 6282 18 occurrence occurrence NN cord-023095-4dannjjm 6282 19 . . . cord-023095-4dannjjm 6283 1 Little little JJ cord-023095-4dannjjm 6283 2 is be VBZ cord-023095-4dannjjm 6283 3 known know VBN cord-023095-4dannjjm 6283 4 about about IN cord-023095-4dannjjm 6283 5 the the DT cord-023095-4dannjjm 6283 6 gastric gastric JJ cord-023095-4dannjjm 6283 7 mucosal mucosal JJ cord-023095-4dannjjm 6283 8 flora flora NNS cord-023095-4dannjjm 6283 9 in in IN cord-023095-4dannjjm 6283 10 healthy healthy JJ cord-023095-4dannjjm 6283 11 horses horse NNS cord-023095-4dannjjm 6283 12 and and CC cord-023095-4dannjjm 6283 13 its -PRON- PRP$ cord-023095-4dannjjm 6283 14 role role NN cord-023095-4dannjjm 6283 15 in in IN cord-023095-4dannjjm 6283 16 gastric gastric JJ cord-023095-4dannjjm 6283 17 disease disease NN cord-023095-4dannjjm 6283 18 has have VBZ cord-023095-4dannjjm 6283 19 not not RB cord-023095-4dannjjm 6283 20 been be VBN cord-023095-4dannjjm 6283 21 critically critically RB cord-023095-4dannjjm 6283 22 examined examine VBN cord-023095-4dannjjm 6283 23 . . . cord-023095-4dannjjm 6284 1 Our -PRON- PRP$ cord-023095-4dannjjm 6284 2 laboratory laboratory NN cord-023095-4dannjjm 6284 3 previously previously RB cord-023095-4dannjjm 6284 4 reported report VBD cord-023095-4dannjjm 6284 5 that that IN cord-023095-4dannjjm 6284 6 a a DT cord-023095-4dannjjm 6284 7 diverse diverse JJ cord-023095-4dannjjm 6284 8 microbial microbial JJ cord-023095-4dannjjm 6284 9 flora flora NNS cord-023095-4dannjjm 6284 10 with with IN cord-023095-4dannjjm 6284 11 a a DT cord-023095-4dannjjm 6284 12 predominance predominance NN cord-023095-4dannjjm 6284 13 of of IN cord-023095-4dannjjm 6284 14 Streptococcus streptococcus NN cord-023095-4dannjjm 6284 15 spp spp NNS cord-023095-4dannjjm 6284 16 . . . cord-023095-4dannjjm 6285 1 and and CC cord-023095-4dannjjm 6285 2 Lactobacillus lactobacillus NN cord-023095-4dannjjm 6285 3 spp spp NNS cord-023095-4dannjjm 6285 4 . . . cord-023095-4dannjjm 6286 1 exists exist VBZ cord-023095-4dannjjm 6286 2 in in IN cord-023095-4dannjjm 6286 3 healthy healthy JJ cord-023095-4dannjjm 6286 4 horses horse NNS cord-023095-4dannjjm 6286 5 using use VBG cord-023095-4dannjjm 6286 6 Fluorescence fluorescence NN cord-023095-4dannjjm 6286 7 in in IN cord-023095-4dannjjm 6286 8 situ situ NN cord-023095-4dannjjm 6286 9 hybridization hybridization NN cord-023095-4dannjjm 6286 10 ( ( -LRB- cord-023095-4dannjjm 6286 11 FISH fish NN cord-023095-4dannjjm 6286 12 ) ) -RRB- cord-023095-4dannjjm 6286 13 . . . cord-023095-4dannjjm 6287 1 The the DT cord-023095-4dannjjm 6287 2 present present JJ cord-023095-4dannjjm 6287 3 study study NN cord-023095-4dannjjm 6287 4 sought seek VBD cord-023095-4dannjjm 6287 5 to to TO cord-023095-4dannjjm 6287 6 further further RB cord-023095-4dannjjm 6287 7 characterize characterize VB cord-023095-4dannjjm 6287 8 the the DT cord-023095-4dannjjm 6287 9 gastric gastric JJ cord-023095-4dannjjm 6287 10 mucosal mucosal JJ cord-023095-4dannjjm 6287 11 flora flora NNS cord-023095-4dannjjm 6287 12 of of IN cord-023095-4dannjjm 6287 13 healthy healthy JJ cord-023095-4dannjjm 6287 14 horses horse NNS cord-023095-4dannjjm 6287 15 using use VBG cord-023095-4dannjjm 6287 16 massive massive JJ cord-023095-4dannjjm 6287 17 parallel parallel JJ cord-023095-4dannjjm 6287 18 16SrRNA 16srrna CD cord-023095-4dannjjm 6287 19 bacterial bacterial JJ cord-023095-4dannjjm 6287 20 tag tag NN cord-023095-4dannjjm 6287 21 encoded encode VBD cord-023095-4dannjjm 6287 22 FLX flx NN cord-023095-4dannjjm 6287 23 - - HYPH cord-023095-4dannjjm 6287 24 titanium titanium NN cord-023095-4dannjjm 6287 25 amplicon amplicon NN cord-023095-4dannjjm 6287 26 pyrosequencing pyrosequencing NN cord-023095-4dannjjm 6287 27 ( ( -LRB- cord-023095-4dannjjm 6287 28 bTEFAP bTEFAP NNP cord-023095-4dannjjm 6287 29 ) ) -RRB- cord-023095-4dannjjm 6287 30 . . . cord-023095-4dannjjm 6288 1 Biopsies biopsy NNS cord-023095-4dannjjm 6288 2 of of IN cord-023095-4dannjjm 6288 3 the the DT cord-023095-4dannjjm 6288 4 squamous squamous JJ cord-023095-4dannjjm 6288 5 , , , cord-023095-4dannjjm 6288 6 glandular glandular JJ cord-023095-4dannjjm 6288 7 , , , cord-023095-4dannjjm 6288 8 antral antral JJ cord-023095-4dannjjm 6288 9 and and CC cord-023095-4dannjjm 6288 10 any any DT cord-023095-4dannjjm 6288 11 ulcerated ulcerated JJ cord-023095-4dannjjm 6288 12 mucosa mucosa NN cord-023095-4dannjjm 6288 13 were be VBD cord-023095-4dannjjm 6288 14 obtained obtain VBN cord-023095-4dannjjm 6288 15 from from IN cord-023095-4dannjjm 6288 16 4 4 CD cord-023095-4dannjjm 6288 17 healthy healthy JJ cord-023095-4dannjjm 6288 18 horses horse NNS cord-023095-4dannjjm 6288 19 via via IN cord-023095-4dannjjm 6288 20 gastroscopy gastroscopy NN cord-023095-4dannjjm 6288 21 after after IN cord-023095-4dannjjm 6288 22 a a DT cord-023095-4dannjjm 6288 23 12-hour 12-hour CD cord-023095-4dannjjm 6288 24 fast fast NN cord-023095-4dannjjm 6288 25 and and CC cord-023095-4dannjjm 6288 26 2 2 CD cord-023095-4dannjjm 6288 27 horses horse NNS cord-023095-4dannjjm 6288 28 immediately immediately RB cord-023095-4dannjjm 6288 29 post post JJ cord-023095-4dannjjm 6288 30 - - JJ cord-023095-4dannjjm 6288 31 mortem mortem JJ cord-023095-4dannjjm 6288 32 . . . cord-023095-4dannjjm 6289 1 DNA DNA NNP cord-023095-4dannjjm 6289 2 was be VBD cord-023095-4dannjjm 6289 3 extracted extract VBN cord-023095-4dannjjm 6289 4 from from IN cord-023095-4dannjjm 6289 5 the the DT cord-023095-4dannjjm 6289 6 mucosal mucosal JJ cord-023095-4dannjjm 6289 7 biopsies biopsy NNS cord-023095-4dannjjm 6289 8 and and CC cord-023095-4dannjjm 6289 9 bTEFAP bTEFAP NNS cord-023095-4dannjjm 6289 10 and and CC cord-023095-4dannjjm 6289 11 data datum NNS cord-023095-4dannjjm 6289 12 processing processing NN cord-023095-4dannjjm 6289 13 was be VBD cord-023095-4dannjjm 6289 14 performed perform VBN cord-023095-4dannjjm 6289 15 . . . cord-023095-4dannjjm 6290 1 Hierarchical hierarchical JJ cord-023095-4dannjjm 6290 2 cluster cluster NN cord-023095-4dannjjm 6290 3 analysis analysis NN cord-023095-4dannjjm 6290 4 based base VBN cord-023095-4dannjjm 6290 5 on on IN cord-023095-4dannjjm 6290 6 relative relative JJ cord-023095-4dannjjm 6290 7 abundance abundance NN cord-023095-4dannjjm 6290 8 data datum NNS cord-023095-4dannjjm 6290 9 on on IN cord-023095-4dannjjm 6290 10 the the DT cord-023095-4dannjjm 6290 11 genus genus NN cord-023095-4dannjjm 6290 12 level level NN cord-023095-4dannjjm 6290 13 were be VBD cord-023095-4dannjjm 6290 14 performed perform VBN cord-023095-4dannjjm 6290 15 to to TO cord-023095-4dannjjm 6290 16 look look VB cord-023095-4dannjjm 6290 17 for for IN cord-023095-4dannjjm 6290 18 trends trend NNS cord-023095-4dannjjm 6290 19 in in IN cord-023095-4dannjjm 6290 20 bacterial bacterial JJ cord-023095-4dannjjm 6290 21 diversity diversity NN cord-023095-4dannjjm 6290 22 among among IN cord-023095-4dannjjm 6290 23 the the DT cord-023095-4dannjjm 6290 24 individual individual JJ cord-023095-4dannjjm 6290 25 horses horse NNS cord-023095-4dannjjm 6290 26 . . . cord-023095-4dannjjm 6291 1 Pyrosequencing pyrosequence VBG cord-023095-4dannjjm 6291 2 yielded yield VBD cord-023095-4dannjjm 6291 3 between between IN cord-023095-4dannjjm 6291 4 4,500 4,500 CD cord-023095-4dannjjm 6291 5 and and CC cord-023095-4dannjjm 6291 6 13,000 13,000 CD cord-023095-4dannjjm 6291 7 reads read NNS cord-023095-4dannjjm 6291 8 per per IN cord-023095-4dannjjm 6291 9 horse horse NN cord-023095-4dannjjm 6291 10 with with IN cord-023095-4dannjjm 6291 11 9238 9238 CD cord-023095-4dannjjm 6291 12 , , , cord-023095-4dannjjm 6291 13 16587 16587 CD cord-023095-4dannjjm 6291 14 , , , cord-023095-4dannjjm 6292 1 16587 16587 CD cord-023095-4dannjjm 6292 2 reads read VBZ cord-023095-4dannjjm 6292 3 in in IN cord-023095-4dannjjm 6292 4 the the DT cord-023095-4dannjjm 6292 5 antrum antrum NN cord-023095-4dannjjm 6292 6 , , , cord-023095-4dannjjm 6292 7 squamous squamous JJ cord-023095-4dannjjm 6292 8 and and CC cord-023095-4dannjjm 6292 9 glandular glandular JJ cord-023095-4dannjjm 6292 10 regions region NNS cord-023095-4dannjjm 6292 11 , , , cord-023095-4dannjjm 6292 12 respectively respectively RB cord-023095-4dannjjm 6292 13 . . . cord-023095-4dannjjm 6293 1 The the DT cord-023095-4dannjjm 6293 2 microbiome microbiome NN cord-023095-4dannjjm 6293 3 segregated segregate VBD cord-023095-4dannjjm 6293 4 into into IN cord-023095-4dannjjm 6293 5 two two CD cord-023095-4dannjjm 6293 6 distinct distinct JJ cord-023095-4dannjjm 6293 7 clusters cluster NNS cord-023095-4dannjjm 6293 8 : : : cord-023095-4dannjjm 6293 9 Cluster cluster NN cord-023095-4dannjjm 6293 10 1 1 CD cord-023095-4dannjjm 6293 11 comprised comprise VBN cord-023095-4dannjjm 6293 12 of of IN cord-023095-4dannjjm 6293 13 2 2 CD cord-023095-4dannjjm 6293 14 horses horse NNS cord-023095-4dannjjm 6293 15 that that WDT cord-023095-4dannjjm 6293 16 were be VBD cord-023095-4dannjjm 6293 17 stabled stable VBN cord-023095-4dannjjm 6293 18 , , , cord-023095-4dannjjm 6293 19 fed fed NNP cord-023095-4dannjjm 6293 20 hay hay NN cord-023095-4dannjjm 6293 21 and and CC cord-023095-4dannjjm 6293 22 sampled sample VBN cord-023095-4dannjjm 6293 23 at at IN cord-023095-4dannjjm 6293 24 post post JJ cord-023095-4dannjjm 6293 25 - - JJ cord-023095-4dannjjm 6293 26 mortem mortem JJ cord-023095-4dannjjm 6293 27 and and CC cord-023095-4dannjjm 6293 28 Cluster cluster NN cord-023095-4dannjjm 6293 29 2 2 CD cord-023095-4dannjjm 6293 30 consisted consist VBD cord-023095-4dannjjm 6293 31 of of IN cord-023095-4dannjjm 6293 32 4 4 CD cord-023095-4dannjjm 6293 33 horses horse NNS cord-023095-4dannjjm 6293 34 that that WDT cord-023095-4dannjjm 6293 35 were be VBD cord-023095-4dannjjm 6293 36 pastured pasture VBN cord-023095-4dannjjm 6293 37 on on IN cord-023095-4dannjjm 6293 38 grass grass NN cord-023095-4dannjjm 6293 39 , , , cord-023095-4dannjjm 6293 40 fed feed VBD cord-023095-4dannjjm 6293 41 hay hay NN cord-023095-4dannjjm 6293 42 and and CC cord-023095-4dannjjm 6293 43 biopsied biopsie VBD cord-023095-4dannjjm 6293 44 gastroscopically gastroscopically RB cord-023095-4dannjjm 6293 45 after after IN cord-023095-4dannjjm 6293 46 a a DT cord-023095-4dannjjm 6293 47 12-hour 12-hour CD cord-023095-4dannjjm 6293 48 fast fast NN cord-023095-4dannjjm 6293 49 . . . cord-023095-4dannjjm 6294 1 Samples sample NNS cord-023095-4dannjjm 6294 2 from from IN cord-023095-4dannjjm 6294 3 different different JJ cord-023095-4dannjjm 6294 4 antomic antomic JJ cord-023095-4dannjjm 6294 5 regions region NNS cord-023095-4dannjjm 6294 6 clustered cluster VBN cord-023095-4dannjjm 6294 7 by by IN cord-023095-4dannjjm 6294 8 horse horse NN cord-023095-4dannjjm 6294 9 rather rather RB cord-023095-4dannjjm 6294 10 than than IN cord-023095-4dannjjm 6294 11 region region NN cord-023095-4dannjjm 6294 12 . . . cord-023095-4dannjjm 6295 1 Despite despite IN cord-023095-4dannjjm 6295 2 being be VBG cord-023095-4dannjjm 6295 3 very very RB cord-023095-4dannjjm 6295 4 similar similar JJ cord-023095-4dannjjm 6295 5 at at IN cord-023095-4dannjjm 6295 6 the the DT cord-023095-4dannjjm 6295 7 higher high JJR cord-023095-4dannjjm 6295 8 taxonomic taxonomic JJ cord-023095-4dannjjm 6295 9 level level NN cord-023095-4dannjjm 6295 10 ( ( -LRB- cord-023095-4dannjjm 6295 11 phyla phylum NNS cord-023095-4dannjjm 6295 12 ) ) -RRB- cord-023095-4dannjjm 6295 13 differences difference NNS cord-023095-4dannjjm 6295 14 in in IN cord-023095-4dannjjm 6295 15 the the DT cord-023095-4dannjjm 6295 16 distribution distribution NN cord-023095-4dannjjm 6295 17 of of IN cord-023095-4dannjjm 6295 18 bacteria bacteria NNS cord-023095-4dannjjm 6295 19 were be VBD cord-023095-4dannjjm 6295 20 seen see VBN cord-023095-4dannjjm 6295 21 at at IN cord-023095-4dannjjm 6295 22 the the DT cord-023095-4dannjjm 6295 23 genus genus NN cord-023095-4dannjjm 6295 24 and and CC cord-023095-4dannjjm 6295 25 species species NN cord-023095-4dannjjm 6295 26 level level NN cord-023095-4dannjjm 6295 27 . . . cord-023095-4dannjjm 6296 1 The the DT cord-023095-4dannjjm 6296 2 dominant dominant JJ cord-023095-4dannjjm 6296 3 bacteria bacteria NNS cord-023095-4dannjjm 6296 4 in in IN cord-023095-4dannjjm 6296 5 Cluster cluster NN cord-023095-4dannjjm 6296 6 1 1 CD cord-023095-4dannjjm 6296 7 horses horse NNS cord-023095-4dannjjm 6296 8 were be VBD cord-023095-4dannjjm 6296 9 Firmicutes Firmicutes NNPS cord-023095-4dannjjm 6296 10 ( ( -LRB- cord-023095-4dannjjm 6296 11 483 483 CD cord-023095-4dannjjm 6296 12 % % NN cord-023095-4dannjjm 6296 13 reads read NNS cord-023095-4dannjjm 6296 14 / / SYM cord-023095-4dannjjm 6296 15 sample sample NN cord-023095-4dannjjm 6296 16 ) ) -RRB- cord-023095-4dannjjm 6296 17 consisting consist VBG cord-023095-4dannjjm 6296 18 of of IN cord-023095-4dannjjm 6296 19 mainly mainly RB cord-023095-4dannjjm 6296 20 Streptococcus streptococcus NN cord-023095-4dannjjm 6296 21 spp spp NNS cord-023095-4dannjjm 6296 22 . . . cord-023095-4dannjjm 6297 1 , , , cord-023095-4dannjjm 6297 2 Lactobacillus Lactobacillus NNP cord-023095-4dannjjm 6297 3 jensenii jensenii NNP cord-023095-4dannjjm 6297 4 , , , cord-023095-4dannjjm 6297 5 L. L. NNP cord-023095-4dannjjm 6297 6 fornicalis fornicalis NNP cord-023095-4dannjjm 6297 7 and and CC cord-023095-4dannjjm 6297 8 Sarcina Sarcina NNP cord-023095-4dannjjm 6297 9 maxima maxima NNP cord-023095-4dannjjm 6297 10 . . . cord-023095-4dannjjm 6298 1 Cluster cluster NN cord-023095-4dannjjm 6298 2 2 2 CD cord-023095-4dannjjm 6298 3 had have VBD cord-023095-4dannjjm 6298 4 more more JJR cord-023095-4dannjjm 6298 5 diversity diversity NN cord-023095-4dannjjm 6298 6 with with IN cord-023095-4dannjjm 6298 7 a a DT cord-023095-4dannjjm 6298 8 predominance predominance NN cord-023095-4dannjjm 6298 9 of of IN cord-023095-4dannjjm 6298 10 Proteobacteria Proteobacteria NNP cord-023095-4dannjjm 6298 11 , , , cord-023095-4dannjjm 6298 12 Bacteroidetes Bacteroidetes NNPS cord-023095-4dannjjm 6298 13 and and CC cord-023095-4dannjjm 6298 14 Firmicutes Firmicutes NNPS cord-023095-4dannjjm 6298 15 and and CC cord-023095-4dannjjm 6298 16 51 51 CD cord-023095-4dannjjm 6298 17 genera genus NNS cord-023095-4dannjjm 6298 18 identified identify VBN cord-023095-4dannjjm 6298 19 such such JJ cord-023095-4dannjjm 6298 20 as as IN cord-023095-4dannjjm 6298 21 Streptococcus Streptococcus NNP cord-023095-4dannjjm 6298 22 spp spp NNS cord-023095-4dannjjm 6298 23 . . . cord-023095-4dannjjm 6299 1 , , , cord-023095-4dannjjm 6299 2 Moraxella Moraxella NNP cord-023095-4dannjjm 6299 3 spp spp NNS cord-023095-4dannjjm 6299 4 . . . cord-023095-4dannjjm 6300 1 , , , cord-023095-4dannjjm 6300 2 Actinobacillus Actinobacillus NNP cord-023095-4dannjjm 6300 3 spp spp NNP cord-023095-4dannjjm 6300 4 . . . cord-023095-4dannjjm 6301 1 , , , cord-023095-4dannjjm 6301 2 and and CC cord-023095-4dannjjm 6301 3 others other NNS cord-023095-4dannjjm 6301 4 . . . cord-023095-4dannjjm 6302 1 Though though IN cord-023095-4dannjjm 6302 2 the the DT cord-023095-4dannjjm 6302 3 relative relative JJ cord-023095-4dannjjm 6302 4 abundance abundance NN cord-023095-4dannjjm 6302 5 of of IN cord-023095-4dannjjm 6302 6 the the DT cord-023095-4dannjjm 6302 7 individual individual JJ cord-023095-4dannjjm 6302 8 taxonomic taxonomic JJ cord-023095-4dannjjm 6302 9 groups group NNS cord-023095-4dannjjm 6302 10 was be VBD cord-023095-4dannjjm 6302 11 significantly significantly RB cord-023095-4dannjjm 6302 12 different different JJ cord-023095-4dannjjm 6302 13 between between IN cord-023095-4dannjjm 6302 14 individual individual JJ cord-023095-4dannjjm 6302 15 horses horse NNS cord-023095-4dannjjm 6302 16 , , , cord-023095-4dannjjm 6302 17 no no DT cord-023095-4dannjjm 6302 18 significant significant JJ cord-023095-4dannjjm 6302 19 differences difference NNS cord-023095-4dannjjm 6302 20 in in IN cord-023095-4dannjjm 6302 21 the the DT cord-023095-4dannjjm 6302 22 overall overall JJ cord-023095-4dannjjm 6302 23 diversity diversity NN cord-023095-4dannjjm 6302 24 could could MD cord-023095-4dannjjm 6302 25 be be VB cord-023095-4dannjjm 6302 26 found find VBN cord-023095-4dannjjm 6302 27 ( ( -LRB- cord-023095-4dannjjm 6302 28 as as IN cord-023095-4dannjjm 6302 29 assesed assese VBN cord-023095-4dannjjm 6302 30 by by IN cord-023095-4dannjjm 6302 31 Shanon Shanon NNP cord-023095-4dannjjm 6302 32 Weaver Weaver NNP cord-023095-4dannjjm 6302 33 , , , cord-023095-4dannjjm 6302 34 ACE ACE NNP cord-023095-4dannjjm 6302 35 and and CC cord-023095-4dannjjm 6302 36 Choa Choa NNP cord-023095-4dannjjm 6302 37 I I NNP cord-023095-4dannjjm 6302 38 diversity diversity NN cord-023095-4dannjjm 6302 39 indices index NNS cord-023095-4dannjjm 6302 40 ) ) -RRB- cord-023095-4dannjjm 6302 41 . . . cord-023095-4dannjjm 6303 1 Helicobacter Helicobacter NNP cord-023095-4dannjjm 6303 2 spp spp NNS cord-023095-4dannjjm 6303 3 . . . cord-023095-4dannjjm 6304 1 sequences sequence NNS cord-023095-4dannjjm 6304 2 were be VBD cord-023095-4dannjjm 6304 3 not not RB cord-023095-4dannjjm 6304 4 identified identify VBN cord-023095-4dannjjm 6304 5 in in IN cord-023095-4dannjjm 6304 6 any any DT cord-023095-4dannjjm 6304 7 sample sample NN cord-023095-4dannjjm 6304 8 ( ( -LRB- cord-023095-4dannjjm 6304 9 out out IN cord-023095-4dannjjm 6304 10 of of IN cord-023095-4dannjjm 6304 11 58,891 58,891 CD cord-023095-4dannjjm 6304 12 reads read NNS cord-023095-4dannjjm 6304 13 ) ) -RRB- cord-023095-4dannjjm 6304 14 . . . cord-023095-4dannjjm 6305 1 The the DT cord-023095-4dannjjm 6305 2 ulcerated ulcerated JJ cord-023095-4dannjjm 6305 3 mucosa mucosa NN cord-023095-4dannjjm 6305 4 from from IN cord-023095-4dannjjm 6305 5 Horse Horse NNP cord-023095-4dannjjm 6305 6 3 3 CD cord-023095-4dannjjm 6305 7 ( ( -LRB- cord-023095-4dannjjm 6305 8 group group NN cord-023095-4dannjjm 6305 9 1 1 CD cord-023095-4dannjjm 6305 10 ) ) -RRB- cord-023095-4dannjjm 6305 11 had have VBD cord-023095-4dannjjm 6305 12 lower low JJR cord-023095-4dannjjm 6305 13 diversity diversity NN cord-023095-4dannjjm 6305 14 and and CC cord-023095-4dannjjm 6305 15 higher high JJR cord-023095-4dannjjm 6305 16 numbers number NNS cord-023095-4dannjjm 6305 17 of of IN cord-023095-4dannjjm 6305 18 bacteria bacteria NNS cord-023095-4dannjjm 6305 19 predominated predominate VBN cord-023095-4dannjjm 6305 20 by by IN cord-023095-4dannjjm 6305 21 Lactobacillus lactobacillus NN cord-023095-4dannjjm 6305 22 equigenerosi equigenerosi NN cord-023095-4dannjjm 6305 23 . . . cord-023095-4dannjjm 6306 1 This this DT cord-023095-4dannjjm 6306 2 data data NN cord-023095-4dannjjm 6306 3 shows show VBZ cord-023095-4dannjjm 6306 4 that that IN cord-023095-4dannjjm 6306 5 the the DT cord-023095-4dannjjm 6306 6 equine equine JJ cord-023095-4dannjjm 6306 7 gastric gastric JJ cord-023095-4dannjjm 6306 8 mucosa mucosa JJ cord-023095-4dannjjm 6306 9 harbors harbor VBZ cord-023095-4dannjjm 6306 10 an an DT cord-023095-4dannjjm 6306 11 abundant abundant JJ cord-023095-4dannjjm 6306 12 and and CC cord-023095-4dannjjm 6306 13 diverse diverse JJ cord-023095-4dannjjm 6306 14 microbiome microbiome NN cord-023095-4dannjjm 6306 15 which which WDT cord-023095-4dannjjm 6306 16 is be VBZ cord-023095-4dannjjm 6306 17 unique unique JJ cord-023095-4dannjjm 6306 18 to to IN cord-023095-4dannjjm 6306 19 each each DT cord-023095-4dannjjm 6306 20 individual individual NN cord-023095-4dannjjm 6306 21 and and CC cord-023095-4dannjjm 6306 22 differs differ VBZ cord-023095-4dannjjm 6306 23 by by IN cord-023095-4dannjjm 6306 24 sampling sampling NN cord-023095-4dannjjm 6306 25 method method NN cord-023095-4dannjjm 6306 26 , , , cord-023095-4dannjjm 6306 27 fasting fast VBG cord-023095-4dannjjm 6306 28 prior prior RB cord-023095-4dannjjm 6306 29 to to IN cord-023095-4dannjjm 6306 30 sampling sampling NN cord-023095-4dannjjm 6306 31 and and CC cord-023095-4dannjjm 6306 32 diet diet NN cord-023095-4dannjjm 6306 33 . . . cord-023095-4dannjjm 6307 1 Seasonal seasonal JJ cord-023095-4dannjjm 6307 2 pasture pasture NN cord-023095-4dannjjm 6307 3 myopathy myopathy NN cord-023095-4dannjjm 6307 4 ( ( -LRB- cord-023095-4dannjjm 6307 5 SPM SPM NNP cord-023095-4dannjjm 6307 6 ; ; , cord-023095-4dannjjm 6307 7 atypical atypical JJ cord-023095-4dannjjm 6307 8 myopathy myopathy NN cord-023095-4dannjjm 6307 9 [ [ -LRB- cord-023095-4dannjjm 6307 10 AM am NN cord-023095-4dannjjm 6307 11 ] ] -RRB- cord-023095-4dannjjm 6307 12 in in IN cord-023095-4dannjjm 6307 13 Europe Europe NNP cord-023095-4dannjjm 6307 14 ) ) -RRB- cord-023095-4dannjjm 6307 15 , , , cord-023095-4dannjjm 6307 16 typified typify VBN cord-023095-4dannjjm 6307 17 by by IN cord-023095-4dannjjm 6307 18 nonexertional nonexertional JJ cord-023095-4dannjjm 6307 19 rhabdomyolysis rhabdomyolysis NN cord-023095-4dannjjm 6307 20 , , , cord-023095-4dannjjm 6307 21 occurs occur VBZ cord-023095-4dannjjm 6307 22 in in IN cord-023095-4dannjjm 6307 23 pastured pastured JJ cord-023095-4dannjjm 6307 24 horses horse NNS cord-023095-4dannjjm 6307 25 during during IN cord-023095-4dannjjm 6307 26 autumn autumn NN cord-023095-4dannjjm 6307 27 or or CC cord-023095-4dannjjm 6307 28 spring spring NN cord-023095-4dannjjm 6307 29 . . . cord-023095-4dannjjm 6308 1 Clinical clinical JJ cord-023095-4dannjjm 6308 2 signs sign NNS cord-023095-4dannjjm 6308 3 rapidly rapidly RB cord-023095-4dannjjm 6308 4 progress progress VBP cord-023095-4dannjjm 6308 5 from from IN cord-023095-4dannjjm 6308 6 muscular muscular JJ cord-023095-4dannjjm 6308 7 weakness weakness NN cord-023095-4dannjjm 6308 8 to to IN cord-023095-4dannjjm 6308 9 recumbency recumbency NN cord-023095-4dannjjm 6308 10 and and CC cord-023095-4dannjjm 6308 11 frequently frequently RB cord-023095-4dannjjm 6308 12 death death NN cord-023095-4dannjjm 6308 13 . . . cord-023095-4dannjjm 6309 1 Extensive extensive JJ cord-023095-4dannjjm 6309 2 myonecrosis myonecrosis NN cord-023095-4dannjjm 6309 3 and and CC cord-023095-4dannjjm 6309 4 intramyofiber intramyofiber NN cord-023095-4dannjjm 6309 5 lipid lipid NN cord-023095-4dannjjm 6309 6 storage storage NN cord-023095-4dannjjm 6309 7 occur occur VBP cord-023095-4dannjjm 6309 8 in in IN cord-023095-4dannjjm 6309 9 highly highly RB cord-023095-4dannjjm 6309 10 oxidative oxidative JJ cord-023095-4dannjjm 6309 11 respiratory respiratory JJ cord-023095-4dannjjm 6309 12 and and CC cord-023095-4dannjjm 6309 13 postural postural JJ cord-023095-4dannjjm 6309 14 muscles muscle NNS cord-023095-4dannjjm 6309 15 . . . cord-023095-4dannjjm 6310 1 Recently recently RB cord-023095-4dannjjm 6310 2 , , , cord-023095-4dannjjm 6310 3 a a DT cord-023095-4dannjjm 6310 4 defect defect NN cord-023095-4dannjjm 6310 5 of of IN cord-023095-4dannjjm 6310 6 lipid lipid NN cord-023095-4dannjjm 6310 7 metabolism metabolism NN cord-023095-4dannjjm 6310 8 called call VBN cord-023095-4dannjjm 6310 9 MADD MADD NNP cord-023095-4dannjjm 6310 10 has have VBZ cord-023095-4dannjjm 6310 11 been be VBN cord-023095-4dannjjm 6310 12 identified identify VBN cord-023095-4dannjjm 6310 13 in in IN cord-023095-4dannjjm 6310 14 European european JJ cord-023095-4dannjjm 6310 15 horses horse NNS cord-023095-4dannjjm 6310 16 with with IN cord-023095-4dannjjm 6310 17 AM AM NNP cord-023095-4dannjjm 6310 18 . . . cord-023095-4dannjjm 6311 1 This this DT cord-023095-4dannjjm 6311 2 report report NN cord-023095-4dannjjm 6311 3 documents document VBZ cord-023095-4dannjjm 6311 4 the the DT cord-023095-4dannjjm 6311 5 first first JJ cord-023095-4dannjjm 6311 6 cases case NNS cord-023095-4dannjjm 6311 7 of of IN cord-023095-4dannjjm 6311 8 equine equine NN cord-023095-4dannjjm 6311 9 MADD MADD NNP cord-023095-4dannjjm 6311 10 in in IN cord-023095-4dannjjm 6311 11 the the DT cord-023095-4dannjjm 6311 12 United United NNP cord-023095-4dannjjm 6311 13 States States NNP cord-023095-4dannjjm 6311 14 . . . cord-023095-4dannjjm 6312 1 Six six CD cord-023095-4dannjjm 6312 2 Midwestern midwestern JJ cord-023095-4dannjjm 6312 3 US US NNP cord-023095-4dannjjm 6312 4 horses horse NNS cord-023095-4dannjjm 6312 5 suspected suspect VBN cord-023095-4dannjjm 6312 6 of of IN cord-023095-4dannjjm 6312 7 having have VBG cord-023095-4dannjjm 6312 8 SPM SPM NNP cord-023095-4dannjjm 6312 9 in in IN cord-023095-4dannjjm 6312 10 the the DT cord-023095-4dannjjm 6312 11 spring spring NN cord-023095-4dannjjm 6312 12 or or CC cord-023095-4dannjjm 6312 13 fall fall NN cord-023095-4dannjjm 6312 14 of of IN cord-023095-4dannjjm 6312 15 2009 2009 CD cord-023095-4dannjjm 6312 16 were be VBD cord-023095-4dannjjm 6312 17 evaluated evaluate VBN cord-023095-4dannjjm 6312 18 for for IN cord-023095-4dannjjm 6312 19 MADD MADD NNP cord-023095-4dannjjm 6312 20 by by IN cord-023095-4dannjjm 6312 21 urine urine NN cord-023095-4dannjjm 6312 22 organic organic JJ cord-023095-4dannjjm 6312 23 acids acid NNS cord-023095-4dannjjm 6312 24 , , , cord-023095-4dannjjm 6312 25 plasma plasma NN cord-023095-4dannjjm 6312 26 acylcarnitines acylcarnitine NNS cord-023095-4dannjjm 6312 27 and/or and/or CC cord-023095-4dannjjm 6312 28 muscle muscle NN cord-023095-4dannjjm 6312 29 carnitine carnitine NN cord-023095-4dannjjm 6312 30 and and CC cord-023095-4dannjjm 6312 31 histopathology histopathology NN cord-023095-4dannjjm 6312 32 . . . cord-023095-4dannjjm 6313 1 Five five CD cord-023095-4dannjjm 6313 2 horses horse NNS cord-023095-4dannjjm 6313 3 had have VBD cord-023095-4dannjjm 6313 4 clinical clinical JJ cord-023095-4dannjjm 6313 5 signs sign NNS cord-023095-4dannjjm 6313 6 and and CC cord-023095-4dannjjm 6313 7 clinicopathologic clinicopathologic NNP cord-023095-4dannjjm 6313 8 data datum NNS cord-023095-4dannjjm 6313 9 consistent consistent JJ cord-023095-4dannjjm 6313 10 with with IN cord-023095-4dannjjm 6313 11 severe severe JJ cord-023095-4dannjjm 6313 12 rhabdomyolysis rhabdomyolysis NN cord-023095-4dannjjm 6313 13 . . . cord-023095-4dannjjm 6314 1 One one CD cord-023095-4dannjjm 6314 2 horse horse NN cord-023095-4dannjjm 6314 3 was be VBD cord-023095-4dannjjm 6314 4 found find VBN cord-023095-4dannjjm 6314 5 dead dead JJ cord-023095-4dannjjm 6314 6 on on IN cord-023095-4dannjjm 6314 7 pasture pasture NN cord-023095-4dannjjm 6314 8 after after IN cord-023095-4dannjjm 6314 9 2 2 CD cord-023095-4dannjjm 6314 10 days day NNS cord-023095-4dannjjm 6314 11 of of IN cord-023095-4dannjjm 6314 12 rear rear JJ cord-023095-4dannjjm 6314 13 limb limb NN cord-023095-4dannjjm 6314 14 stiffness stiffness NN cord-023095-4dannjjm 6314 15 and and CC cord-023095-4dannjjm 6314 16 inappetance inappetance NN cord-023095-4dannjjm 6314 17 . . . cord-023095-4dannjjm 6315 1 Urinary urinary JJ cord-023095-4dannjjm 6315 2 organic organic JJ cord-023095-4dannjjm 6315 3 acid acid NN cord-023095-4dannjjm 6315 4 profiles profile NNS cord-023095-4dannjjm 6315 5 revealed reveal VBD cord-023095-4dannjjm 6315 6 markedly markedly RB cord-023095-4dannjjm 6315 7 elevated elevate VBN cord-023095-4dannjjm 6315 8 ethylmalonic ethylmalonic JJ cord-023095-4dannjjm 6315 9 and and CC cord-023095-4dannjjm 6315 10 methylsuccinic methylsuccinic JJ cord-023095-4dannjjm 6315 11 acids acid NNS cord-023095-4dannjjm 6315 12 , , , cord-023095-4dannjjm 6315 13 butyrylglycine butyrylglycine NNP cord-023095-4dannjjm 6315 14 , , , cord-023095-4dannjjm 6315 15 isovalerylglycine isovalerylglycine NNP cord-023095-4dannjjm 6315 16 , , , cord-023095-4dannjjm 6315 17 and and CC cord-023095-4dannjjm 6315 18 hexanoylglycine hexanoylglycine NN cord-023095-4dannjjm 6315 19 , , , cord-023095-4dannjjm 6315 20 consistent consistent JJ cord-023095-4dannjjm 6315 21 with with IN cord-023095-4dannjjm 6315 22 equine equine JJ cord-023095-4dannjjm 6315 23 MADD MADD NNP cord-023095-4dannjjm 6315 24 . . . cord-023095-4dannjjm 6316 1 Plasma plasma NN cord-023095-4dannjjm 6316 2 acylcarnitine acylcarnitine NN cord-023095-4dannjjm 6316 3 profiles profile NNS cord-023095-4dannjjm 6316 4 from from IN cord-023095-4dannjjm 6316 5 2 2 CD cord-023095-4dannjjm 6316 6 horses horse NNS cord-023095-4dannjjm 6316 7 had have VBD cord-023095-4dannjjm 6316 8 marked mark VBN cord-023095-4dannjjm 6316 9 elevations elevation NNS cord-023095-4dannjjm 6316 10 of of IN cord-023095-4dannjjm 6316 11 short short JJ cord-023095-4dannjjm 6316 12 chain chain NN cord-023095-4dannjjm 6316 13 acylcarnitines acylcarnitine NNS cord-023095-4dannjjm 6316 14 , , , cord-023095-4dannjjm 6316 15 while while IN cord-023095-4dannjjm 6316 16 the the DT cord-023095-4dannjjm 6316 17 third third JJ cord-023095-4dannjjm 6316 18 horse horse NN cord-023095-4dannjjm 6316 19 and and CC cord-023095-4dannjjm 6316 20 only only JJ cord-023095-4dannjjm 6316 21 survivor survivor NN cord-023095-4dannjjm 6316 22 had have VBD cord-023095-4dannjjm 6316 23 minor minor JJ cord-023095-4dannjjm 6316 24 elevations elevation NNS cord-023095-4dannjjm 6316 25 of of IN cord-023095-4dannjjm 6316 26 short short JJ cord-023095-4dannjjm 6316 27 chain chain NN cord-023095-4dannjjm 6316 28 acylcarnitines acylcarnitine NNS cord-023095-4dannjjm 6316 29 . . . cord-023095-4dannjjm 6317 1 Affected affected JJ cord-023095-4dannjjm 6317 2 muscle muscle NN cord-023095-4dannjjm 6317 3 showed show VBD cord-023095-4dannjjm 6317 4 extensive extensive JJ cord-023095-4dannjjm 6317 5 degeneration degeneration NN cord-023095-4dannjjm 6317 6 with with IN cord-023095-4dannjjm 6317 7 intramyofiber intramyofiber NNP cord-023095-4dannjjm 6317 8 lipid lipid NN cord-023095-4dannjjm 6317 9 accumulation accumulation NN cord-023095-4dannjjm 6317 10 , , , cord-023095-4dannjjm 6317 11 a a DT cord-023095-4dannjjm 6317 12 marked marked JJ cord-023095-4dannjjm 6317 13 decrease decrease NN cord-023095-4dannjjm 6317 14 in in IN cord-023095-4dannjjm 6317 15 free free JJ cord-023095-4dannjjm 6317 16 carnitine carnitine NN cord-023095-4dannjjm 6317 17 , , , cord-023095-4dannjjm 6317 18 and and CC cord-023095-4dannjjm 6317 19 high high JJ cord-023095-4dannjjm 6317 20 levels level NNS cord-023095-4dannjjm 6317 21 of of IN cord-023095-4dannjjm 6317 22 carnitine carnitine NN cord-023095-4dannjjm 6317 23 esters ester NNS cord-023095-4dannjjm 6317 24 . . . cord-023095-4dannjjm 6318 1 SPM SPM NNP cord-023095-4dannjjm 6318 2 appears appear VBZ cord-023095-4dannjjm 6318 3 to to TO cord-023095-4dannjjm 6318 4 be be VB cord-023095-4dannjjm 6318 5 a a DT cord-023095-4dannjjm 6318 6 highly highly RB cord-023095-4dannjjm 6318 7 fatal fatal JJ cord-023095-4dannjjm 6318 8 emerging emerge VBG cord-023095-4dannjjm 6318 9 disease disease NN cord-023095-4dannjjm 6318 10 of of IN cord-023095-4dannjjm 6318 11 pastured pastured JJ cord-023095-4dannjjm 6318 12 horses horse NNS cord-023095-4dannjjm 6318 13 in in IN cord-023095-4dannjjm 6318 14 the the DT cord-023095-4dannjjm 6318 15 US US NNP cord-023095-4dannjjm 6318 16 characterized characterize VBN cord-023095-4dannjjm 6318 17 by by IN cord-023095-4dannjjm 6318 18 weakness weakness NN cord-023095-4dannjjm 6318 19 , , , cord-023095-4dannjjm 6318 20 colic colic NN cord-023095-4dannjjm 6318 21 - - HYPH cord-023095-4dannjjm 6318 22 like like JJ cord-023095-4dannjjm 6318 23 signs sign NNS cord-023095-4dannjjm 6318 24 and and CC cord-023095-4dannjjm 6318 25 myoglobinuria myoglobinuria NNS cord-023095-4dannjjm 6318 26 . . . cord-023095-4dannjjm 6319 1 The the DT cord-023095-4dannjjm 6319 2 disease disease NN cord-023095-4dannjjm 6319 3 is be VBZ cord-023095-4dannjjm 6319 4 associated associate VBN cord-023095-4dannjjm 6319 5 with with IN cord-023095-4dannjjm 6319 6 a a DT cord-023095-4dannjjm 6319 7 defect defect NN cord-023095-4dannjjm 6319 8 in in IN cord-023095-4dannjjm 6319 9 muscular muscular JJ cord-023095-4dannjjm 6319 10 lipid lipid NN cord-023095-4dannjjm 6319 11 metabolism metabolism NN cord-023095-4dannjjm 6319 12 that that WDT cord-023095-4dannjjm 6319 13 can can MD cord-023095-4dannjjm 6319 14 be be VB cord-023095-4dannjjm 6319 15 diagnosed diagnose VBN cord-023095-4dannjjm 6319 16 by by IN cord-023095-4dannjjm 6319 17 performing perform VBG cord-023095-4dannjjm 6319 18 lipid lipid NN cord-023095-4dannjjm 6319 19 staining staining NN cord-023095-4dannjjm 6319 20 of of IN cord-023095-4dannjjm 6319 21 muscle muscle NN cord-023095-4dannjjm 6319 22 samples sample NNS cord-023095-4dannjjm 6319 23 and and CC cord-023095-4dannjjm 6319 24 urine urine VB cord-023095-4dannjjm 6319 25 organic organic JJ cord-023095-4dannjjm 6319 26 acid acid NN cord-023095-4dannjjm 6319 27 profiles profile NNS cord-023095-4dannjjm 6319 28 . . . cord-023095-4dannjjm 6320 1 Candidatus Candidatus NNP cord-023095-4dannjjm 6320 2 Mycoplasma Mycoplasma NNP cord-023095-4dannjjm 6320 3 haemolamae haemolamae NN cord-023095-4dannjjm 6320 4 ( ( -LRB- cord-023095-4dannjjm 6320 5 CMhl CMhl NNP cord-023095-4dannjjm 6320 6 ) ) -RRB- cord-023095-4dannjjm 6320 7 is be VBZ cord-023095-4dannjjm 6320 8 a a DT cord-023095-4dannjjm 6320 9 common common JJ cord-023095-4dannjjm 6320 10 red red JJ cord-023095-4dannjjm 6320 11 blood blood NN cord-023095-4dannjjm 6320 12 cell cell NN cord-023095-4dannjjm 6320 13 parasite parasite NN cord-023095-4dannjjm 6320 14 of of IN cord-023095-4dannjjm 6320 15 new new JJ cord-023095-4dannjjm 6320 16 world world NN cord-023095-4dannjjm 6320 17 camelids camelid NNS cord-023095-4dannjjm 6320 18 . . . cord-023095-4dannjjm 6321 1 The the DT cord-023095-4dannjjm 6321 2 high high JJ cord-023095-4dannjjm 6321 3 degree degree NN cord-023095-4dannjjm 6321 4 of of IN cord-023095-4dannjjm 6321 5 parasitemia parasitemia NN cord-023095-4dannjjm 6321 6 that that WDT cord-023095-4dannjjm 6321 7 develops develop VBZ cord-023095-4dannjjm 6321 8 in in IN cord-023095-4dannjjm 6321 9 an an DT cord-023095-4dannjjm 6321 10 infected infected JJ cord-023095-4dannjjm 6321 11 splenectomized splenectomize VBN cord-023095-4dannjjm 6321 12 animal animal NN cord-023095-4dannjjm 6321 13 allows allow VBZ cord-023095-4dannjjm 6321 14 for for IN cord-023095-4dannjjm 6321 15 the the DT cord-023095-4dannjjm 6321 16 efficient efficient JJ cord-023095-4dannjjm 6321 17 collection collection NN cord-023095-4dannjjm 6321 18 of of IN cord-023095-4dannjjm 6321 19 parasitic parasitic JJ cord-023095-4dannjjm 6321 20 DNA dna NN cord-023095-4dannjjm 6321 21 . . . cord-023095-4dannjjm 6322 1 This this DT cord-023095-4dannjjm 6322 2 DNA dna NN cord-023095-4dannjjm 6322 3 can can MD cord-023095-4dannjjm 6322 4 then then RB cord-023095-4dannjjm 6322 5 be be VB cord-023095-4dannjjm 6322 6 used use VBN cord-023095-4dannjjm 6322 7 in in IN cord-023095-4dannjjm 6322 8 the the DT cord-023095-4dannjjm 6322 9 development development NN cord-023095-4dannjjm 6322 10 of of IN cord-023095-4dannjjm 6322 11 genetically genetically RB cord-023095-4dannjjm 6322 12 - - HYPH cord-023095-4dannjjm 6322 13 derived derive VBN cord-023095-4dannjjm 6322 14 tools tool NNS cord-023095-4dannjjm 6322 15 such such JJ cord-023095-4dannjjm 6322 16 as as IN cord-023095-4dannjjm 6322 17 PCR PCR NNP cord-023095-4dannjjm 6322 18 and and CC cord-023095-4dannjjm 6322 19 in in IN cord-023095-4dannjjm 6322 20 - - HYPH cord-023095-4dannjjm 6322 21 situ situ NN cord-023095-4dannjjm 6322 22 hybridization hybridization NN cord-023095-4dannjjm 6322 23 . . . cord-023095-4dannjjm 6323 1 Thus thus RB cord-023095-4dannjjm 6323 2 , , , cord-023095-4dannjjm 6323 3 one one CD cord-023095-4dannjjm 6323 4 splenectomized splenectomize VBN cord-023095-4dannjjm 6323 5 animal animal NN cord-023095-4dannjjm 6323 6 can can MD cord-023095-4dannjjm 6323 7 replace replace VB cord-023095-4dannjjm 6323 8 many many JJ cord-023095-4dannjjm 6323 9 immunologically immunologically RB cord-023095-4dannjjm 6323 10 intact intact JJ cord-023095-4dannjjm 6323 11 animals animal NNS cord-023095-4dannjjm 6323 12 within within IN cord-023095-4dannjjm 6323 13 a a DT cord-023095-4dannjjm 6323 14 research research NN cord-023095-4dannjjm 6323 15 setting setting NN cord-023095-4dannjjm 6323 16 . . . cord-023095-4dannjjm 6324 1 The the DT cord-023095-4dannjjm 6324 2 purpose purpose NN cord-023095-4dannjjm 6324 3 of of IN cord-023095-4dannjjm 6324 4 this this DT cord-023095-4dannjjm 6324 5 study study NN cord-023095-4dannjjm 6324 6 was be VBD cord-023095-4dannjjm 6324 7 to to TO cord-023095-4dannjjm 6324 8 track track VB cord-023095-4dannjjm 6324 9 the the DT cord-023095-4dannjjm 6324 10 natural natural JJ cord-023095-4dannjjm 6324 11 progression progression NN cord-023095-4dannjjm 6324 12 of of IN cord-023095-4dannjjm 6324 13 CMhl CMhl NNP cord-023095-4dannjjm 6324 14 parasitemia parasitemia NNP cord-023095-4dannjjm 6324 15 and and CC cord-023095-4dannjjm 6324 16 associated associate VBD cord-023095-4dannjjm 6324 17 clinical clinical JJ cord-023095-4dannjjm 6324 18 signs sign NNS cord-023095-4dannjjm 6324 19 in in IN cord-023095-4dannjjm 6324 20 a a DT cord-023095-4dannjjm 6324 21 splenectomized splenectomized JJ cord-023095-4dannjjm 6324 22 alpaca alpaca NN cord-023095-4dannjjm 6324 23 . . . cord-023095-4dannjjm 6325 1 An an DT cord-023095-4dannjjm 6325 2 intact intact JJ cord-023095-4dannjjm 6325 3 , , , cord-023095-4dannjjm 6325 4 9-month 9-month JJ cord-023095-4dannjjm 6325 5 - - HYPH cord-023095-4dannjjm 6325 6 old old JJ cord-023095-4dannjjm 6325 7 , , , cord-023095-4dannjjm 6325 8 39.1 39.1 CD cord-023095-4dannjjm 6325 9 kg kg NN cord-023095-4dannjjm 6325 10 male male JJ cord-023095-4dannjjm 6325 11 alpaca alpaca NN cord-023095-4dannjjm 6325 12 was be VBD cord-023095-4dannjjm 6325 13 used use VBN cord-023095-4dannjjm 6325 14 in in IN cord-023095-4dannjjm 6325 15 this this DT cord-023095-4dannjjm 6325 16 study study NN cord-023095-4dannjjm 6325 17 . . . cord-023095-4dannjjm 6326 1 He -PRON- PRP cord-023095-4dannjjm 6326 2 had have VBD cord-023095-4dannjjm 6326 3 tested test VBN cord-023095-4dannjjm 6326 4 positive positive JJ cord-023095-4dannjjm 6326 5 via via IN cord-023095-4dannjjm 6326 6 PCR PCR NNP cord-023095-4dannjjm 6326 7 for for IN cord-023095-4dannjjm 6326 8 CMhl CMhl NNP cord-023095-4dannjjm 6326 9 on on IN cord-023095-4dannjjm 6326 10 three three CD cord-023095-4dannjjm 6326 11 different different JJ cord-023095-4dannjjm 6326 12 occasions occasion NNS cord-023095-4dannjjm 6326 13 , , , cord-023095-4dannjjm 6326 14 although although IN cord-023095-4dannjjm 6326 15 no no DT cord-023095-4dannjjm 6326 16 organisms organism NNS cord-023095-4dannjjm 6326 17 were be VBD cord-023095-4dannjjm 6326 18 seen see VBN cord-023095-4dannjjm 6326 19 on on IN cord-023095-4dannjjm 6326 20 peripheral peripheral JJ cord-023095-4dannjjm 6326 21 blood blood NN cord-023095-4dannjjm 6326 22 smears smear NNS cord-023095-4dannjjm 6326 23 . . . cord-023095-4dannjjm 6327 1 The the DT cord-023095-4dannjjm 6327 2 alpaca alpaca NN cord-023095-4dannjjm 6327 3 was be VBD cord-023095-4dannjjm 6327 4 placed place VBN cord-023095-4dannjjm 6327 5 under under IN cord-023095-4dannjjm 6327 6 general general JJ cord-023095-4dannjjm 6327 7 anesthesia anesthesia NN cord-023095-4dannjjm 6327 8 and and CC cord-023095-4dannjjm 6327 9 a a DT cord-023095-4dannjjm 6327 10 ventral ventral JJ cord-023095-4dannjjm 6327 11 midline midline JJ cord-023095-4dannjjm 6327 12 incision incision NN cord-023095-4dannjjm 6327 13 was be VBD cord-023095-4dannjjm 6327 14 made make VBN cord-023095-4dannjjm 6327 15 . . . cord-023095-4dannjjm 6328 1 The the DT cord-023095-4dannjjm 6328 2 spleen spleen NN cord-023095-4dannjjm 6328 3 was be VBD cord-023095-4dannjjm 6328 4 located locate VBN cord-023095-4dannjjm 6328 5 , , , cord-023095-4dannjjm 6328 6 the the DT cord-023095-4dannjjm 6328 7 vessels vessel NNS cord-023095-4dannjjm 6328 8 ligated ligate VBN cord-023095-4dannjjm 6328 9 , , , cord-023095-4dannjjm 6328 10 and and CC cord-023095-4dannjjm 6328 11 the the DT cord-023095-4dannjjm 6328 12 organ organ NN cord-023095-4dannjjm 6328 13 removed remove VBN cord-023095-4dannjjm 6328 14 . . . cord-023095-4dannjjm 6329 1 Buprenorphine Buprenorphine NNP cord-023095-4dannjjm 6329 2 and and CC cord-023095-4dannjjm 6329 3 flunixin flunixin NNP cord-023095-4dannjjm 6329 4 meglumine meglumine NNP cord-023095-4dannjjm 6329 5 were be VBD cord-023095-4dannjjm 6329 6 given give VBN cord-023095-4dannjjm 6329 7 for for IN cord-023095-4dannjjm 6329 8 2 2 CD cord-023095-4dannjjm 6329 9 and and CC cord-023095-4dannjjm 6329 10 4 4 CD cord-023095-4dannjjm 6329 11 days day NNS cord-023095-4dannjjm 6329 12 after after IN cord-023095-4dannjjm 6329 13 surgery surgery NN cord-023095-4dannjjm 6329 14 respectively respectively RB cord-023095-4dannjjm 6329 15 . . . cord-023095-4dannjjm 6330 1 Body body NN cord-023095-4dannjjm 6330 2 weight weight NN cord-023095-4dannjjm 6330 3 , , , cord-023095-4dannjjm 6330 4 attitude attitude NN cord-023095-4dannjjm 6330 5 , , , cord-023095-4dannjjm 6330 6 rectal rectal JJ cord-023095-4dannjjm 6330 7 temperature temperature NN cord-023095-4dannjjm 6330 8 , , , cord-023095-4dannjjm 6330 9 blood blood NN cord-023095-4dannjjm 6330 10 glucose glucose NN cord-023095-4dannjjm 6330 11 , , , cord-023095-4dannjjm 6330 12 and and CC cord-023095-4dannjjm 6330 13 PCV PCV NNP cord-023095-4dannjjm 6330 14 were be VBD cord-023095-4dannjjm 6330 15 recorded record VBN cord-023095-4dannjjm 6330 16 daily daily RB cord-023095-4dannjjm 6330 17 . . . cord-023095-4dannjjm 6331 1 In in IN cord-023095-4dannjjm 6331 2 addition addition NN cord-023095-4dannjjm 6331 3 , , , cord-023095-4dannjjm 6331 4 a a DT cord-023095-4dannjjm 6331 5 peripheral peripheral JJ cord-023095-4dannjjm 6331 6 blood blood NN cord-023095-4dannjjm 6331 7 smear smear NN cord-023095-4dannjjm 6331 8 was be VBD cord-023095-4dannjjm 6331 9 examined examine VBN cord-023095-4dannjjm 6331 10 daily daily RB cord-023095-4dannjjm 6331 11 and and CC cord-023095-4dannjjm 6331 12 the the DT cord-023095-4dannjjm 6331 13 percent percent NN cord-023095-4dannjjm 6331 14 of of IN cord-023095-4dannjjm 6331 15 red red JJ cord-023095-4dannjjm 6331 16 blood blood NN cord-023095-4dannjjm 6331 17 cells cell NNS cord-023095-4dannjjm 6331 18 that that WDT cord-023095-4dannjjm 6331 19 were be VBD cord-023095-4dannjjm 6331 20 infected infect VBN cord-023095-4dannjjm 6331 21 with with IN cord-023095-4dannjjm 6331 22 Mycoplasma mycoplasma NN cord-023095-4dannjjm 6331 23 organisms organism NNS cord-023095-4dannjjm 6331 24 was be VBD cord-023095-4dannjjm 6331 25 determined determine VBN cord-023095-4dannjjm 6331 26 . . . cord-023095-4dannjjm 6332 1 The the DT cord-023095-4dannjjm 6332 2 alpaca alpaca NN cord-023095-4dannjjm 6332 3 was be VBD cord-023095-4dannjjm 6332 4 not not RB cord-023095-4dannjjm 6332 5 parasitemic parasitemic NNP cord-023095-4dannjjm 6332 6 prior prior RB cord-023095-4dannjjm 6332 7 to to IN cord-023095-4dannjjm 6332 8 surgery surgery NN cord-023095-4dannjjm 6332 9 . . . cord-023095-4dannjjm 6333 1 One one CD cord-023095-4dannjjm 6333 2 percent percent NN cord-023095-4dannjjm 6333 3 of of IN cord-023095-4dannjjm 6333 4 the the DT cord-023095-4dannjjm 6333 5 RBC RBC NNP cord-023095-4dannjjm 6333 6 's 's POS cord-023095-4dannjjm 6333 7 contained contain VBD cord-023095-4dannjjm 6333 8 mycoplasma mycoplasma NN cord-023095-4dannjjm 6333 9 on on IN cord-023095-4dannjjm 6333 10 days day NNS cord-023095-4dannjjm 6333 11 2 2 CD cord-023095-4dannjjm 6333 12 and and CC cord-023095-4dannjjm 6333 13 3 3 CD cord-023095-4dannjjm 6333 14 after after IN cord-023095-4dannjjm 6333 15 splenectomy splenectomy NN cord-023095-4dannjjm 6333 16 . . . cord-023095-4dannjjm 6334 1 Parasitic parasitic JJ cord-023095-4dannjjm 6334 2 bloom bloom NN cord-023095-4dannjjm 6334 3 developed develop VBN cord-023095-4dannjjm 6334 4 on on IN cord-023095-4dannjjm 6334 5 day day NN cord-023095-4dannjjm 6334 6 4 4 CD cord-023095-4dannjjm 6334 7 with with IN cord-023095-4dannjjm 6334 8 85 85 CD cord-023095-4dannjjm 6334 9 % % NN cord-023095-4dannjjm 6334 10 of of IN cord-023095-4dannjjm 6334 11 the the DT cord-023095-4dannjjm 6334 12 red red JJ cord-023095-4dannjjm 6334 13 blood blood NN cord-023095-4dannjjm 6334 14 cells cell NNS cord-023095-4dannjjm 6334 15 infected infect VBN cord-023095-4dannjjm 6334 16 , , , cord-023095-4dannjjm 6334 17 and and CC cord-023095-4dannjjm 6334 18 over over IN cord-023095-4dannjjm 6334 19 70 70 CD cord-023095-4dannjjm 6334 20 % % NN cord-023095-4dannjjm 6334 21 containing contain VBG cord-023095-4dannjjm 6334 22 3 3 CD cord-023095-4dannjjm 6334 23 or or CC cord-023095-4dannjjm 6334 24 more more JJR cord-023095-4dannjjm 6334 25 organisms organism NNS cord-023095-4dannjjm 6334 26 . . . cord-023095-4dannjjm 6335 1 The the DT cord-023095-4dannjjm 6335 2 alpaca alpaca NN cord-023095-4dannjjm 6335 3 was be VBD cord-023095-4dannjjm 6335 4 treated treat VBN cord-023095-4dannjjm 6335 5 with with IN cord-023095-4dannjjm 6335 6 20 20 CD cord-023095-4dannjjm 6335 7 mg mg NNP cord-023095-4dannjjm 6335 8 / / SYM cord-023095-4dannjjm 6335 9 kg kg NNP cord-023095-4dannjjm 6335 10 Oxytetracycline Oxytetracycline NNP cord-023095-4dannjjm 6335 11 I.V. I.V. NNP cord-023095-4dannjjm 6335 12 on on IN cord-023095-4dannjjm 6335 13 day day NN cord-023095-4dannjjm 6335 14 4 4 CD cord-023095-4dannjjm 6335 15 . . . cord-023095-4dannjjm 6336 1 On on IN cord-023095-4dannjjm 6336 2 postoperative postoperative JJ cord-023095-4dannjjm 6336 3 day day NN cord-023095-4dannjjm 6336 4 5 5 CD cord-023095-4dannjjm 6336 5 no no DT cord-023095-4dannjjm 6336 6 parasites parasite NNS cord-023095-4dannjjm 6336 7 were be VBD cord-023095-4dannjjm 6336 8 seen see VBN cord-023095-4dannjjm 6336 9 in in IN cord-023095-4dannjjm 6336 10 the the DT cord-023095-4dannjjm 6336 11 peripheral peripheral JJ cord-023095-4dannjjm 6336 12 blood blood NN cord-023095-4dannjjm 6336 13 . . . cord-023095-4dannjjm 6337 1 The the DT cord-023095-4dannjjm 6337 2 peripheral peripheral JJ cord-023095-4dannjjm 6337 3 blood blood NN cord-023095-4dannjjm 6337 4 remained remain VBD cord-023095-4dannjjm 6337 5 free free JJ cord-023095-4dannjjm 6337 6 of of IN cord-023095-4dannjjm 6337 7 parasites parasite NNS cord-023095-4dannjjm 6337 8 for for IN cord-023095-4dannjjm 6337 9 11 11 CD cord-023095-4dannjjm 6337 10 days day NNS cord-023095-4dannjjm 6337 11 . . . cord-023095-4dannjjm 6338 1 On on IN cord-023095-4dannjjm 6338 2 the the DT cord-023095-4dannjjm 6338 3 morning morning NN cord-023095-4dannjjm 6338 4 of of IN cord-023095-4dannjjm 6338 5 the the DT cord-023095-4dannjjm 6338 6 12 12 CD cord-023095-4dannjjm 6338 7 th th CD cord-023095-4dannjjm 6338 8 day day NN cord-023095-4dannjjm 6338 9 , , , cord-023095-4dannjjm 6338 10 3 3 CD cord-023095-4dannjjm 6338 11 % % NN cord-023095-4dannjjm 6338 12 of of IN cord-023095-4dannjjm 6338 13 the the DT cord-023095-4dannjjm 6338 14 peripheral peripheral JJ cord-023095-4dannjjm 6338 15 red red JJ cord-023095-4dannjjm 6338 16 blood blood NN cord-023095-4dannjjm 6338 17 cells cell NNS cord-023095-4dannjjm 6338 18 contained contain VBD cord-023095-4dannjjm 6338 19 Mycoplasma Mycoplasma NNP cord-023095-4dannjjm 6338 20 . . . cord-023095-4dannjjm 6339 1 By by IN cord-023095-4dannjjm 6339 2 late late RB cord-023095-4dannjjm 6339 3 that that DT cord-023095-4dannjjm 6339 4 afternoon afternoon NN cord-023095-4dannjjm 6339 5 , , , cord-023095-4dannjjm 6339 6 75 75 CD cord-023095-4dannjjm 6339 7 % % NN cord-023095-4dannjjm 6339 8 of of IN cord-023095-4dannjjm 6339 9 the the DT cord-023095-4dannjjm 6339 10 observed observed JJ cord-023095-4dannjjm 6339 11 RBC RBC NNP cord-023095-4dannjjm 6339 12 's 's POS cord-023095-4dannjjm 6339 13 contained contain VBD cord-023095-4dannjjm 6339 14 3 3 CD cord-023095-4dannjjm 6339 15 - - SYM cord-023095-4dannjjm 6339 16 4 4 CD cord-023095-4dannjjm 6339 17 organisms organism NNS cord-023095-4dannjjm 6339 18 . . . cord-023095-4dannjjm 6340 1 The the DT cord-023095-4dannjjm 6340 2 alpaca alpaca NN cord-023095-4dannjjm 6340 3 again again RB cord-023095-4dannjjm 6340 4 received receive VBD cord-023095-4dannjjm 6340 5 oxytetracycline oxytetracycline NN cord-023095-4dannjjm 6340 6 . . . cord-023095-4dannjjm 6341 1 There there EX cord-023095-4dannjjm 6341 2 were be VBD cord-023095-4dannjjm 6341 3 no no DT cord-023095-4dannjjm 6341 4 more more JJR cord-023095-4dannjjm 6341 5 parasites parasite NNS cord-023095-4dannjjm 6341 6 observed observe VBN cord-023095-4dannjjm 6341 7 from from IN cord-023095-4dannjjm 6341 8 that that DT cord-023095-4dannjjm 6341 9 time time NN cord-023095-4dannjjm 6341 10 until until IN cord-023095-4dannjjm 6341 11 the the DT cord-023095-4dannjjm 6341 12 alpaca alpaca NN cord-023095-4dannjjm 6341 13 was be VBD cord-023095-4dannjjm 6341 14 euthanized euthanize VBN cord-023095-4dannjjm 6341 15 5 5 CD cord-023095-4dannjjm 6341 16 days day NNS cord-023095-4dannjjm 6341 17 later later RB cord-023095-4dannjjm 6341 18 . . . cord-023095-4dannjjm 6342 1 The the DT cord-023095-4dannjjm 6342 2 alpaca alpaca NN cord-023095-4dannjjm 6342 3 lost lose VBD cord-023095-4dannjjm 6342 4 3.7 3.7 CD cord-023095-4dannjjm 6342 5 kg kg NNS cord-023095-4dannjjm 6342 6 between between IN cord-023095-4dannjjm 6342 7 days day NNS cord-023095-4dannjjm 6342 8 À1 À1 NNP cord-023095-4dannjjm 6342 9 and and CC cord-023095-4dannjjm 6342 10 12 12 CD cord-023095-4dannjjm 6342 11 after after IN cord-023095-4dannjjm 6342 12 surgery surgery NN cord-023095-4dannjjm 6342 13 . . . cord-023095-4dannjjm 6343 1 His -PRON- PRP$ cord-023095-4dannjjm 6343 2 weight weight NN cord-023095-4dannjjm 6343 3 fluctuated fluctuate VBD cord-023095-4dannjjm 6343 4 between between IN cord-023095-4dannjjm 6343 5 34.9 34.9 CD cord-023095-4dannjjm 6343 6 and and CC cord-023095-4dannjjm 6343 7 35.4 35.4 CD cord-023095-4dannjjm 6343 8 kg kg NNS cord-023095-4dannjjm 6343 9 for for IN cord-023095-4dannjjm 6343 10 the the DT cord-023095-4dannjjm 6343 11 remainder remainder NN cord-023095-4dannjjm 6343 12 of of IN cord-023095-4dannjjm 6343 13 the the DT cord-023095-4dannjjm 6343 14 study study NN cord-023095-4dannjjm 6343 15 period period NN cord-023095-4dannjjm 6343 16 . . . cord-023095-4dannjjm 6344 1 Blood blood NN cord-023095-4dannjjm 6344 2 glucose glucose NN cord-023095-4dannjjm 6344 3 ranged range VBD cord-023095-4dannjjm 6344 4 between between IN cord-023095-4dannjjm 6344 5 87 87 CD cord-023095-4dannjjm 6344 6 and and CC cord-023095-4dannjjm 6344 7 163 163 CD cord-023095-4dannjjm 6345 1 mg mg NNP cord-023095-4dannjjm 6345 2 / / SYM cord-023095-4dannjjm 6345 3 dL dl NN cord-023095-4dannjjm 6346 1 There there EX cord-023095-4dannjjm 6346 2 was be VBD cord-023095-4dannjjm 6346 3 no no DT cord-023095-4dannjjm 6346 4 major major JJ cord-023095-4dannjjm 6346 5 change change NN cord-023095-4dannjjm 6346 6 in in IN cord-023095-4dannjjm 6346 7 PCV PCV NNP cord-023095-4dannjjm 6346 8 ( ( -LRB- cord-023095-4dannjjm 6346 9 range range NNP cord-023095-4dannjjm 6346 10 21 21 CD cord-023095-4dannjjm 6346 11 - - SYM cord-023095-4dannjjm 6346 12 29 29 CD cord-023095-4dannjjm 6346 13 % % NN cord-023095-4dannjjm 6346 14 ) ) -RRB- cord-023095-4dannjjm 6346 15 , , , cord-023095-4dannjjm 6346 16 a a DT cord-023095-4dannjjm 6346 17 finding finding NN cord-023095-4dannjjm 6346 18 that that WDT cord-023095-4dannjjm 6346 19 was be VBD cord-023095-4dannjjm 6346 20 expected expect VBN cord-023095-4dannjjm 6346 21 as as IN cord-023095-4dannjjm 6346 22 the the DT cord-023095-4dannjjm 6346 23 spleen spleen NN cord-023095-4dannjjm 6346 24 was be VBD cord-023095-4dannjjm 6346 25 not not RB cord-023095-4dannjjm 6346 26 available available JJ cord-023095-4dannjjm 6346 27 to to TO cord-023095-4dannjjm 6346 28 remove remove VB cord-023095-4dannjjm 6346 29 infected infected JJ cord-023095-4dannjjm 6346 30 red red JJ cord-023095-4dannjjm 6346 31 blood blood NN cord-023095-4dannjjm 6346 32 cells cell NNS cord-023095-4dannjjm 6346 33 . . . cord-023095-4dannjjm 6347 1 Body body NN cord-023095-4dannjjm 6347 2 temperature temperature NN cord-023095-4dannjjm 6347 3 ranged range VBD cord-023095-4dannjjm 6348 1 between between IN cord-023095-4dannjjm 6348 2 38.1 38.1 CD cord-023095-4dannjjm 6348 3 and and CC cord-023095-4dannjjm 6348 4 39 39 CD cord-023095-4dannjjm 6348 5 degrees degree NNS cord-023095-4dannjjm 6348 6 Celsius Celsius NNP cord-023095-4dannjjm 6348 7 except except IN cord-023095-4dannjjm 6348 8 for for IN cord-023095-4dannjjm 6348 9 days day NNS cord-023095-4dannjjm 6348 10 4 4 CD cord-023095-4dannjjm 6348 11 and and CC cord-023095-4dannjjm 6348 12 16 16 CD cord-023095-4dannjjm 6348 13 when when WRB cord-023095-4dannjjm 6348 14 more more JJR cord-023095-4dannjjm 6348 15 than than IN cord-023095-4dannjjm 6348 16 70 70 CD cord-023095-4dannjjm 6348 17 % % NN cord-023095-4dannjjm 6348 18 of of IN cord-023095-4dannjjm 6348 19 red red JJ cord-023095-4dannjjm 6348 20 blood blood NN cord-023095-4dannjjm 6348 21 cells cell NNS cord-023095-4dannjjm 6348 22 contained contain VBD cord-023095-4dannjjm 6348 23 parasites parasite NNS cord-023095-4dannjjm 6348 24 . . . cord-023095-4dannjjm 6349 1 On on IN cord-023095-4dannjjm 6349 2 those those DT cord-023095-4dannjjm 6349 3 days day NNS cord-023095-4dannjjm 6349 4 rectal rectal JJ cord-023095-4dannjjm 6349 5 temperature temperature NN cord-023095-4dannjjm 6349 6 reached reach VBD cord-023095-4dannjjm 6349 7 39.4 39.4 CD cord-023095-4dannjjm 6349 8 and and CC cord-023095-4dannjjm 6349 9 39.1 39.1 CD cord-023095-4dannjjm 6349 10 degrees degree NNS cord-023095-4dannjjm 6349 11 respectively respectively RB cord-023095-4dannjjm 6349 12 . . . cord-023095-4dannjjm 6350 1 This this DT cord-023095-4dannjjm 6350 2 study study NN cord-023095-4dannjjm 6350 3 confirmed confirm VBD cord-023095-4dannjjm 6350 4 that that IN cord-023095-4dannjjm 6350 5 a a DT cord-023095-4dannjjm 6350 6 non non JJ cord-023095-4dannjjm 6350 7 - - JJ cord-023095-4dannjjm 6350 8 parasitemic parasitemic JJ cord-023095-4dannjjm 6350 9 , , , cord-023095-4dannjjm 6350 10 yet yet RB cord-023095-4dannjjm 6350 11 PCR PCR NNP cord-023095-4dannjjm 6350 12 positive positive JJ cord-023095-4dannjjm 6350 13 alpaca alpaca NN cord-023095-4dannjjm 6350 14 did do VBD cord-023095-4dannjjm 6350 15 indeed indeed RB cord-023095-4dannjjm 6350 16 harbor harbor VB cord-023095-4dannjjm 6350 17 CMhl CMhl NNP cord-023095-4dannjjm 6350 18 . . . cord-023095-4dannjjm 6351 1 The the DT cord-023095-4dannjjm 6351 2 time time NN cord-023095-4dannjjm 6351 3 from from IN cord-023095-4dannjjm 6351 4 splenectomy splenectomy NN cord-023095-4dannjjm 6351 5 to to IN cord-023095-4dannjjm 6351 6 parasitic parasitic JJ cord-023095-4dannjjm 6351 7 bloom bloom NN cord-023095-4dannjjm 6351 8 was be VBD cord-023095-4dannjjm 6351 9 shorter short JJR cord-023095-4dannjjm 6351 10 , , , cord-023095-4dannjjm 6351 11 and and CC cord-023095-4dannjjm 6351 12 the the DT cord-023095-4dannjjm 6351 13 length length NN cord-023095-4dannjjm 6351 14 of of IN cord-023095-4dannjjm 6351 15 oxytetracycline oxytetracycline NN cord-023095-4dannjjm 6351 16 suppression suppression NN cord-023095-4dannjjm 6351 17 longer long RBR cord-023095-4dannjjm 6351 18 than than IN cord-023095-4dannjjm 6351 19 has have VBZ cord-023095-4dannjjm 6351 20 been be VBN cord-023095-4dannjjm 6351 21 observed observe VBN cord-023095-4dannjjm 6351 22 in in IN cord-023095-4dannjjm 6351 23 other other JJ cord-023095-4dannjjm 6351 24 species specie NNS cord-023095-4dannjjm 6351 25 . . . cord-023095-4dannjjm 6352 1 Gastro gastro JJ cord-023095-4dannjjm 6352 2 - - HYPH cord-023095-4dannjjm 6352 3 intestinal intestinal JJ cord-023095-4dannjjm 6352 4 ( ( -LRB- cord-023095-4dannjjm 6352 5 GI GI NNP cord-023095-4dannjjm 6352 6 ) ) -RRB- cord-023095-4dannjjm 6352 7 disease disease NN cord-023095-4dannjjm 6352 8 frequently frequently RB cord-023095-4dannjjm 6352 9 results result VBZ cord-023095-4dannjjm 6352 10 in in IN cord-023095-4dannjjm 6352 11 increased increase VBN cord-023095-4dannjjm 6352 12 wall wall NN cord-023095-4dannjjm 6352 13 thickness thickness NN cord-023095-4dannjjm 6352 14 in in IN cord-023095-4dannjjm 6352 15 many many JJ cord-023095-4dannjjm 6352 16 species specie NNS cord-023095-4dannjjm 6352 17 . . . cord-023095-4dannjjm 6353 1 Identification identification NN cord-023095-4dannjjm 6353 2 of of IN cord-023095-4dannjjm 6353 3 changes change NNS cord-023095-4dannjjm 6353 4 in in IN cord-023095-4dannjjm 6353 5 GI GI NNP cord-023095-4dannjjm 6353 6 wall wall NN cord-023095-4dannjjm 6353 7 thickness thickness NN cord-023095-4dannjjm 6353 8 using use VBG cord-023095-4dannjjm 6353 9 ultrasound ultrasound NN cord-023095-4dannjjm 6353 10 has have VBZ cord-023095-4dannjjm 6353 11 proved prove VBN cord-023095-4dannjjm 6353 12 to to TO cord-023095-4dannjjm 6353 13 be be VB cord-023095-4dannjjm 6353 14 a a DT cord-023095-4dannjjm 6353 15 useful useful JJ cord-023095-4dannjjm 6353 16 diagnostic diagnostic JJ cord-023095-4dannjjm 6353 17 tool tool NN cord-023095-4dannjjm 6353 18 and and CC cord-023095-4dannjjm 6353 19 is be VBZ cord-023095-4dannjjm 6353 20 widely widely RB cord-023095-4dannjjm 6353 21 used use VBN cord-023095-4dannjjm 6353 22 in in IN cord-023095-4dannjjm 6353 23 human human JJ cord-023095-4dannjjm 6353 24 patients patient NNS cord-023095-4dannjjm 6353 25 , , , cord-023095-4dannjjm 6353 26 small small JJ cord-023095-4dannjjm 6353 27 animals animal NNS cord-023095-4dannjjm 6353 28 and and CC cord-023095-4dannjjm 6353 29 horses horse NNS cord-023095-4dannjjm 6353 30 . . . cord-023095-4dannjjm 6354 1 Although although IN cord-023095-4dannjjm 6354 2 GI GI NNP cord-023095-4dannjjm 6354 3 motility motility NN cord-023095-4dannjjm 6354 4 has have VBZ cord-023095-4dannjjm 6354 5 been be VBN cord-023095-4dannjjm 6354 6 evaluated evaluate VBN cord-023095-4dannjjm 6354 7 in in IN cord-023095-4dannjjm 6354 8 cattle cattle NNS cord-023095-4dannjjm 6354 9 , , , cord-023095-4dannjjm 6354 10 normal normal JJ cord-023095-4dannjjm 6354 11 reference reference NN cord-023095-4dannjjm 6354 12 ranges range VBZ cord-023095-4dannjjm 6354 13 for for IN cord-023095-4dannjjm 6354 14 wall wall NN cord-023095-4dannjjm 6354 15 thickness thickness NN cord-023095-4dannjjm 6354 16 has have VBZ cord-023095-4dannjjm 6354 17 not not RB cord-023095-4dannjjm 6354 18 been be VBN cord-023095-4dannjjm 6354 19 reported report VBN cord-023095-4dannjjm 6354 20 in in IN cord-023095-4dannjjm 6354 21 ruminants ruminant NNS cord-023095-4dannjjm 6354 22 . . . cord-023095-4dannjjm 6355 1 The the DT cord-023095-4dannjjm 6355 2 aims aim NNS cord-023095-4dannjjm 6355 3 of of IN cord-023095-4dannjjm 6355 4 this this DT cord-023095-4dannjjm 6355 5 study study NN cord-023095-4dannjjm 6355 6 were be VBD cord-023095-4dannjjm 6355 7 to to TO cord-023095-4dannjjm 6355 8 report report VB cord-023095-4dannjjm 6355 9 normal normal JJ cord-023095-4dannjjm 6355 10 values value NNS cord-023095-4dannjjm 6355 11 for for IN cord-023095-4dannjjm 6355 12 wall wall NN cord-023095-4dannjjm 6355 13 thickness thickness NN cord-023095-4dannjjm 6355 14 of of IN cord-023095-4dannjjm 6355 15 various various JJ cord-023095-4dannjjm 6355 16 GI GI NNP cord-023095-4dannjjm 6355 17 structures structure NNS cord-023095-4dannjjm 6355 18 and and CC cord-023095-4dannjjm 6355 19 to to TO cord-023095-4dannjjm 6355 20 assess assess VB cord-023095-4dannjjm 6355 21 the the DT cord-023095-4dannjjm 6355 22 repeatability repeatability NN cord-023095-4dannjjm 6355 23 of of IN cord-023095-4dannjjm 6355 24 this this DT cord-023095-4dannjjm 6355 25 technique technique NN cord-023095-4dannjjm 6355 26 in in IN cord-023095-4dannjjm 6355 27 adult adult NN cord-023095-4dannjjm 6355 28 dairy dairy NN cord-023095-4dannjjm 6355 29 cows cow NNS cord-023095-4dannjjm 6355 30 , , , cord-023095-4dannjjm 6355 31 sheep sheep NNS cord-023095-4dannjjm 6355 32 and and CC cord-023095-4dannjjm 6355 33 goats goat NNS cord-023095-4dannjjm 6355 34 . . . cord-023095-4dannjjm 6356 1 Eight eight CD cord-023095-4dannjjm 6356 2 healthy healthy JJ cord-023095-4dannjjm 6356 3 adult adult NN cord-023095-4dannjjm 6356 4 Holstein Holstein NNP cord-023095-4dannjjm 6356 5 Friesian Friesian NNP cord-023095-4dannjjm 6356 6 ( ( -LRB- cord-023095-4dannjjm 6356 7 HF HF NNP cord-023095-4dannjjm 6356 8 ) ) -RRB- cord-023095-4dannjjm 6356 9 cattle cattle NNS cord-023095-4dannjjm 6356 10 ( ( -LRB- cord-023095-4dannjjm 6356 11 656 656 CD cord-023095-4dannjjm 6356 12 AE AE NNP cord-023095-4dannjjm 6356 13 11 11 CD cord-023095-4dannjjm 6356 14 Kg Kg NNP cord-023095-4dannjjm 6356 15 ) ) -RRB- cord-023095-4dannjjm 6356 16 , , , cord-023095-4dannjjm 6356 17 eight eight CD cord-023095-4dannjjm 6356 18 Jersey Jersey NNP cord-023095-4dannjjm 6356 19 ( ( -LRB- cord-023095-4dannjjm 6356 20 J J NNP cord-023095-4dannjjm 6356 21 ) ) -RRB- cord-023095-4dannjjm 6356 22 cattle cattle NNS cord-023095-4dannjjm 6356 23 ( ( -LRB- cord-023095-4dannjjm 6356 24 458 458 CD cord-023095-4dannjjm 6356 25 AE AE NNP cord-023095-4dannjjm 6356 26 56 56 CD cord-023095-4dannjjm 6356 27 kg kg NNS cord-023095-4dannjjm 6356 28 ) ) -RRB- cord-023095-4dannjjm 6356 29 , , , cord-023095-4dannjjm 6356 30 thirteen thirteen CD cord-023095-4dannjjm 6356 31 adult adult NN cord-023095-4dannjjm 6356 32 sheep sheep NNS cord-023095-4dannjjm 6356 33 ( ( -LRB- cord-023095-4dannjjm 6356 34 79 79 CD cord-023095-4dannjjm 6356 35 AE AE NNP cord-023095-4dannjjm 6356 36 11 11 CD cord-023095-4dannjjm 6356 37 Kg Kg NNP cord-023095-4dannjjm 6356 38 ) ) -RRB- cord-023095-4dannjjm 6356 39 and and CC cord-023095-4dannjjm 6356 40 eleven eleven CD cord-023095-4dannjjm 6356 41 adult adult NN cord-023095-4dannjjm 6356 42 goats goat NNS cord-023095-4dannjjm 6356 43 ( ( -LRB- cord-023095-4dannjjm 6356 44 43.5 43.5 CD cord-023095-4dannjjm 6356 45 AE AE NNP cord-023095-4dannjjm 6356 46 8 8 CD cord-023095-4dannjjm 6356 47 Kg Kg NNP cord-023095-4dannjjm 6356 48 ) ) -RRB- cord-023095-4dannjjm 6356 49 were be VBD cord-023095-4dannjjm 6356 50 recruited recruit VBN cord-023095-4dannjjm 6356 51 and and CC cord-023095-4dannjjm 6356 52 examined examine VBN cord-023095-4dannjjm 6356 53 on on IN cord-023095-4dannjjm 6356 54 three three CD cord-023095-4dannjjm 6356 55 consecutive consecutive JJ cord-023095-4dannjjm 6356 56 days day NNS cord-023095-4dannjjm 6356 57 . . . cord-023095-4dannjjm 6357 1 Ultrasonographic ultrasonographic JJ cord-023095-4dannjjm 6357 2 images image NNS cord-023095-4dannjjm 6357 3 were be VBD cord-023095-4dannjjm 6357 4 optimised optimise VBN cord-023095-4dannjjm 6357 5 for for IN cord-023095-4dannjjm 6357 6 the the DT cord-023095-4dannjjm 6357 7 structure structure NN cord-023095-4dannjjm 6357 8 of of IN cord-023095-4dannjjm 6357 9 interest interest NN cord-023095-4dannjjm 6357 10 . . . cord-023095-4dannjjm 6358 1 Structures structure NNS cord-023095-4dannjjm 6358 2 were be VBD cord-023095-4dannjjm 6358 3 identified identify VBN cord-023095-4dannjjm 6358 4 based base VBN cord-023095-4dannjjm 6358 5 upon upon IN cord-023095-4dannjjm 6358 6 appearance appearance NN cord-023095-4dannjjm 6358 7 and and CC cord-023095-4dannjjm 6358 8 anatomical anatomical JJ cord-023095-4dannjjm 6358 9 position position NN cord-023095-4dannjjm 6358 10 . . . cord-023095-4dannjjm 6359 1 A a DT cord-023095-4dannjjm 6359 2 minimum minimum NN cord-023095-4dannjjm 6359 3 of of IN cord-023095-4dannjjm 6359 4 three three CD cord-023095-4dannjjm 6359 5 cineloops cineloop NNS cord-023095-4dannjjm 6359 6 were be VBD cord-023095-4dannjjm 6359 7 obtained obtain VBN cord-023095-4dannjjm 6359 8 of of IN cord-023095-4dannjjm 6359 9 the the DT cord-023095-4dannjjm 6359 10 abdominal abdominal JJ cord-023095-4dannjjm 6359 11 organs organ NNS cord-023095-4dannjjm 6359 12 per per IN cord-023095-4dannjjm 6359 13 intercostal intercostal JJ cord-023095-4dannjjm 6359 14 space space NN cord-023095-4dannjjm 6359 15 ( ( -LRB- cord-023095-4dannjjm 6359 16 ICS ICS NNP cord-023095-4dannjjm 6359 17 ) ) -RRB- cord-023095-4dannjjm 6359 18 and and CC cord-023095-4dannjjm 6359 19 three three CD cord-023095-4dannjjm 6359 20 along along IN cord-023095-4dannjjm 6359 21 the the DT cord-023095-4dannjjm 6359 22 ventral ventral JJ cord-023095-4dannjjm 6359 23 midline midline NN cord-023095-4dannjjm 6359 24 in in IN cord-023095-4dannjjm 6359 25 each each DT cord-023095-4dannjjm 6359 26 ICS ICS NNP cord-023095-4dannjjm 6359 27 ; ; : cord-023095-4dannjjm 6359 28 images image NNS cord-023095-4dannjjm 6359 29 were be VBD cord-023095-4dannjjm 6359 30 analysed analyse VBN cord-023095-4dannjjm 6359 31 offline offline JJ cord-023095-4dannjjm 6359 32 . . . cord-023095-4dannjjm 6360 1 Data datum NNS cord-023095-4dannjjm 6360 2 were be VBD cord-023095-4dannjjm 6360 3 analysed analyse VBN cord-023095-4dannjjm 6360 4 using use VBG cord-023095-4dannjjm 6360 5 ANOVA ANOVA NNP cord-023095-4dannjjm 6360 6 and and CC cord-023095-4dannjjm 6360 7 post post VB cord-023095-4dannjjm 6360 8 - - JJ cord-023095-4dannjjm 6360 9 hoc hoc JJ cord-023095-4dannjjm 6360 10 Bonferoni Bonferoni NNP cord-023095-4dannjjm 6360 11 , , , cord-023095-4dannjjm 6360 12 Student Student NNP cord-023095-4dannjjm 6360 13 's 's POS cord-023095-4dannjjm 6360 14 Ttest Ttest NNP cord-023095-4dannjjm 6360 15 and and CC cord-023095-4dannjjm 6360 16 intra intra JJ cord-023095-4dannjjm 6360 17 - - JJ cord-023095-4dannjjm 6360 18 class class JJ cord-023095-4dannjjm 6360 19 correlation correlation NN cord-023095-4dannjjm 6360 20 coefficients coefficient NNS cord-023095-4dannjjm 6360 21 . . . cord-023095-4dannjjm 6361 1 Each each DT cord-023095-4dannjjm 6361 2 structure structure NN cord-023095-4dannjjm 6361 3 was be VBD cord-023095-4dannjjm 6361 4 measured measure VBN cord-023095-4dannjjm 6361 5 per per IN cord-023095-4dannjjm 6361 6 ICS ics NN cord-023095-4dannjjm 6361 7 per per IN cord-023095-4dannjjm 6361 8 species specie NNS cord-023095-4dannjjm 6361 9 ; ; : cord-023095-4dannjjm 6361 10 if if IN cord-023095-4dannjjm 6361 11 no no DT cord-023095-4dannjjm 6361 12 differences difference NNS cord-023095-4dannjjm 6361 13 were be VBD cord-023095-4dannjjm 6361 14 noted note VBN cord-023095-4dannjjm 6361 15 for for IN cord-023095-4dannjjm 6361 16 structures structure NNS cord-023095-4dannjjm 6361 17 in in IN cord-023095-4dannjjm 6361 18 different different JJ cord-023095-4dannjjm 6361 19 ICS ICS NNP cord-023095-4dannjjm 6361 20 , , , cord-023095-4dannjjm 6361 21 then then RB cord-023095-4dannjjm 6361 22 measurements measurement NNS cord-023095-4dannjjm 6361 23 were be VBD cord-023095-4dannjjm 6361 24 pooled pool VBN cord-023095-4dannjjm 6361 25 . . . cord-023095-4dannjjm 6362 1 No no DT cord-023095-4dannjjm 6362 2 differences difference NNS cord-023095-4dannjjm 6362 3 were be VBD cord-023095-4dannjjm 6362 4 noted note VBN cord-023095-4dannjjm 6362 5 between between IN cord-023095-4dannjjm 6362 6 HF HF NNP cord-023095-4dannjjm 6362 7 and and CC cord-023095-4dannjjm 6362 8 J J NNP cord-023095-4dannjjm 6362 9 cattle cattle NNS cord-023095-4dannjjm 6363 1 so so CC cord-023095-4dannjjm 6363 2 data datum NNS cord-023095-4dannjjm 6363 3 were be VBD cord-023095-4dannjjm 6363 4 pooled pool VBN cord-023095-4dannjjm 6363 5 . . . cord-023095-4dannjjm 6364 1 Data datum NNS cord-023095-4dannjjm 6364 2 are be VBP cord-023095-4dannjjm 6364 3 displayed display VBN cord-023095-4dannjjm 6364 4 in in IN cord-023095-4dannjjm 6364 5 table table NN cord-023095-4dannjjm 6364 6 1 1 CD cord-023095-4dannjjm 6364 7 . . . cord-023095-4dannjjm 6365 1 Good good JJ cord-023095-4dannjjm 6365 2 repeatability repeatability NN cord-023095-4dannjjm 6365 3 ( ( -LRB- cord-023095-4dannjjm 6365 4 ICC40.91 ICC40.91 NNP cord-023095-4dannjjm 6365 5 ) ) -RRB- cord-023095-4dannjjm 6365 6 was be VBD cord-023095-4dannjjm 6365 7 obtained obtain VBN cord-023095-4dannjjm 6365 8 for for IN cord-023095-4dannjjm 6365 9 all all DT cord-023095-4dannjjm 6365 10 measurements measurement NNS cord-023095-4dannjjm 6365 11 and and CC cord-023095-4dannjjm 6365 12 no no DT cord-023095-4dannjjm 6365 13 differences difference NNS cord-023095-4dannjjm 6365 14 were be VBD cord-023095-4dannjjm 6365 15 noted note VBN cord-023095-4dannjjm 6365 16 between between IN cord-023095-4dannjjm 6365 17 animals animal NNS cord-023095-4dannjjm 6365 18 of of IN cord-023095-4dannjjm 6365 19 the the DT cord-023095-4dannjjm 6365 20 same same JJ cord-023095-4dannjjm 6365 21 species specie NNS cord-023095-4dannjjm 6365 22 or or CC cord-023095-4dannjjm 6365 23 between between IN cord-023095-4dannjjm 6365 24 days day NNS cord-023095-4dannjjm 6365 25 . . . cord-023095-4dannjjm 6366 1 These these DT cord-023095-4dannjjm 6366 2 measurements measurement NNS cord-023095-4dannjjm 6366 3 for for IN cord-023095-4dannjjm 6366 4 assessment assessment NN cord-023095-4dannjjm 6366 5 of of IN cord-023095-4dannjjm 6366 6 normal normal JJ cord-023095-4dannjjm 6366 7 GI GI NNP cord-023095-4dannjjm 6366 8 thickness thickness NN cord-023095-4dannjjm 6366 9 are be VBP cord-023095-4dannjjm 6366 10 repeatable repeatable JJ cord-023095-4dannjjm 6366 11 and and CC cord-023095-4dannjjm 6366 12 may may MD cord-023095-4dannjjm 6366 13 allow allow VB cord-023095-4dannjjm 6366 14 valuable valuable JJ cord-023095-4dannjjm 6366 15 additional additional JJ cord-023095-4dannjjm 6366 16 information information NN cord-023095-4dannjjm 6366 17 to to TO cord-023095-4dannjjm 6366 18 be be VB cord-023095-4dannjjm 6366 19 gained gain VBN cord-023095-4dannjjm 6366 20 from from IN cord-023095-4dannjjm 6366 21 ruminants ruminant NNS cord-023095-4dannjjm 6366 22 with with IN cord-023095-4dannjjm 6366 23 GI GI NNP cord-023095-4dannjjm 6366 24 disease disease NN cord-023095-4dannjjm 6366 25 . . . cord-023095-4dannjjm 6367 1 Ocular ocular JJ cord-023095-4dannjjm 6367 2 infections infection NNS cord-023095-4dannjjm 6367 3 with with IN cord-023095-4dannjjm 6367 4 the the DT cord-023095-4dannjjm 6367 5 infectious infectious JJ cord-023095-4dannjjm 6367 6 bovine bovine NN cord-023095-4dannjjm 6367 7 keratoconjunctivitis keratoconjunctivitis NN cord-023095-4dannjjm 6367 8 ( ( -LRB- cord-023095-4dannjjm 6367 9 IBK IBK NNP cord-023095-4dannjjm 6367 10 ) ) -RRB- cord-023095-4dannjjm 6367 11 agent agent NN cord-023095-4dannjjm 6367 12 Moraxella Moraxella NNP cord-023095-4dannjjm 6367 13 bovis bovi NNS cord-023095-4dannjjm 6367 14 ( ( -LRB- cord-023095-4dannjjm 6367 15 M. M. NNP cord-023095-4dannjjm 6367 16 bovis bovi NNS cord-023095-4dannjjm 6367 17 ) ) -RRB- cord-023095-4dannjjm 6367 18 are be VBP cord-023095-4dannjjm 6367 19 associated associate VBN cord-023095-4dannjjm 6367 20 with with IN cord-023095-4dannjjm 6367 21 significant significant JJ cord-023095-4dannjjm 6367 22 economic economic JJ cord-023095-4dannjjm 6367 23 loss loss NN cord-023095-4dannjjm 6367 24 in in IN cord-023095-4dannjjm 6367 25 the the DT cord-023095-4dannjjm 6367 26 cattle cattle NNS cord-023095-4dannjjm 6367 27 industry industry NN cord-023095-4dannjjm 6367 28 . . . cord-023095-4dannjjm 6368 1 Although although IN cord-023095-4dannjjm 6368 2 antibiotic antibiotic JJ cord-023095-4dannjjm 6368 3 therapy therapy NN cord-023095-4dannjjm 6368 4 is be VBZ cord-023095-4dannjjm 6368 5 the the DT cord-023095-4dannjjm 6368 6 treatment treatment NN cord-023095-4dannjjm 6368 7 of of IN cord-023095-4dannjjm 6368 8 choice choice NN cord-023095-4dannjjm 6368 9 for for IN cord-023095-4dannjjm 6368 10 IBK IBK NNP cord-023095-4dannjjm 6368 11 , , , cord-023095-4dannjjm 6368 12 treatment treatment NN cord-023095-4dannjjm 6368 13 failures failure NNS cord-023095-4dannjjm 6368 14 are be VBP cord-023095-4dannjjm 6369 1 common common JJ cord-023095-4dannjjm 6369 2 and and CC cord-023095-4dannjjm 6369 3 current current JJ cord-023095-4dannjjm 6369 4 vaccines vaccine NNS cord-023095-4dannjjm 6369 5 are be VBP cord-023095-4dannjjm 6369 6 not not RB cord-023095-4dannjjm 6369 7 optimally optimally RB cord-023095-4dannjjm 6369 8 effective effective JJ cord-023095-4dannjjm 6369 9 mainly mainly RB cord-023095-4dannjjm 6369 10 due due JJ cord-023095-4dannjjm 6369 11 to to IN cord-023095-4dannjjm 6369 12 antigenic antigenic JJ cord-023095-4dannjjm 6369 13 variation variation NN cord-023095-4dannjjm 6369 14 . . . cord-023095-4dannjjm 6370 1 As as IN cord-023095-4dannjjm 6370 2 a a DT cord-023095-4dannjjm 6370 3 result result NN cord-023095-4dannjjm 6370 4 , , , cord-023095-4dannjjm 6370 5 our -PRON- PRP$ cord-023095-4dannjjm 6370 6 laboratory laboratory NN cord-023095-4dannjjm 6370 7 has have VBZ cord-023095-4dannjjm 6370 8 been be VBN cord-023095-4dannjjm 6370 9 actively actively RB cord-023095-4dannjjm 6370 10 investigating investigate VBG cord-023095-4dannjjm 6370 11 the the DT cord-023095-4dannjjm 6370 12 therapeutic therapeutic JJ cord-023095-4dannjjm 6370 13 potential potential NN cord-023095-4dannjjm 6370 14 of of IN cord-023095-4dannjjm 6370 15 Bdellovibrio Bdellovibrio NNP cord-023095-4dannjjm 6370 16 bacteriovorus bacteriovorus NNP cord-023095-4dannjjm 6370 17 109J 109J NNP cord-023095-4dannjjm 6370 18 ( ( -LRB- cord-023095-4dannjjm 6370 19 B. B. NNP cord-023095-4dannjjm 6370 20 bacteriovorus bacteriovorus NNP cord-023095-4dannjjm 6370 21 ) ) -RRB- cord-023095-4dannjjm 6370 22 ; ; : cord-023095-4dannjjm 6370 23 a a DT cord-023095-4dannjjm 6370 24 predatory predatory JJ cord-023095-4dannjjm 6370 25 bacterium bacterium NN cord-023095-4dannjjm 6370 26 capable capable JJ cord-023095-4dannjjm 6370 27 of of IN cord-023095-4dannjjm 6370 28 attacking attack VBG cord-023095-4dannjjm 6370 29 and and CC cord-023095-4dannjjm 6370 30 inducing induce VBG cord-023095-4dannjjm 6370 31 lysis lysis NN cord-023095-4dannjjm 6370 32 of of IN cord-023095-4dannjjm 6370 33 Gram gram NN cord-023095-4dannjjm 6370 34 - - HYPH cord-023095-4dannjjm 6370 35 negative negative JJ cord-023095-4dannjjm 6370 36 bacteria bacteria NNS cord-023095-4dannjjm 6370 37 , , , cord-023095-4dannjjm 6370 38 as as IN cord-023095-4dannjjm 6370 39 a a DT cord-023095-4dannjjm 6370 40 new new JJ cord-023095-4dannjjm 6370 41 treatment treatment NN cord-023095-4dannjjm 6370 42 for for IN cord-023095-4dannjjm 6370 43 IBK IBK NNP cord-023095-4dannjjm 6370 44 . . . cord-023095-4dannjjm 6371 1 We -PRON- PRP cord-023095-4dannjjm 6371 2 have have VBP cord-023095-4dannjjm 6371 3 previously previously RB cord-023095-4dannjjm 6371 4 shown show VBN cord-023095-4dannjjm 6371 5 that that IN cord-023095-4dannjjm 6371 6 B. B. NNP cord-023095-4dannjjm 6371 7 bacteriovorus bacteriovorus NNP cord-023095-4dannjjm 6371 8 can can MD cord-023095-4dannjjm 6371 9 reduce reduce VB cord-023095-4dannjjm 6371 10 the the DT cord-023095-4dannjjm 6371 11 number number NN cord-023095-4dannjjm 6371 12 of of IN cord-023095-4dannjjm 6371 13 M. M. NNP cord-023095-4dannjjm 6371 14 bovis bovi NNS cord-023095-4dannjjm 6371 15 attached attach VBN cord-023095-4dannjjm 6371 16 to to IN cord-023095-4dannjjm 6371 17 bovine bovine JJ cord-023095-4dannjjm 6371 18 epithelial epithelial JJ cord-023095-4dannjjm 6371 19 cells cell NNS cord-023095-4dannjjm 6371 20 in in IN cord-023095-4dannjjm 6371 21 an an DT cord-023095-4dannjjm 6371 22 in in FW cord-023095-4dannjjm 6371 23 vitro vitro FW cord-023095-4dannjjm 6371 24 model model NN cord-023095-4dannjjm 6371 25 of of IN cord-023095-4dannjjm 6371 26 IBK IBK NNP cord-023095-4dannjjm 6371 27 and and CC cord-023095-4dannjjm 6371 28 that that IN cord-023095-4dannjjm 6371 29 B. B. NNP cord-023095-4dannjjm 6371 30 bacteriovorus bacteriovorus NNP cord-023095-4dannjjm 6371 31 can can MD cord-023095-4dannjjm 6371 32 be be VB cord-023095-4dannjjm 6371 33 trained train VBN cord-023095-4dannjjm 6371 34 to to TO cord-023095-4dannjjm 6371 35 kill kill VB cord-023095-4dannjjm 6371 36 M. M. NNP cord-023095-4dannjjm 6371 37 bovis bovi NNS cord-023095-4dannjjm 6371 38 as as RB cord-023095-4dannjjm 6371 39 effectively effectively RB cord-023095-4dannjjm 6371 40 as as IN cord-023095-4dannjjm 6371 41 E. E. NNP cord-023095-4dannjjm 6371 42 coli coli NNS cord-023095-4dannjjm 6371 43 using use VBG cord-023095-4dannjjm 6371 44 serial serial JJ cord-023095-4dannjjm 6371 45 passages passage NNS cord-023095-4dannjjm 6371 46 . . . cord-023095-4dannjjm 6372 1 In in IN cord-023095-4dannjjm 6372 2 this this DT cord-023095-4dannjjm 6372 3 study study NN cord-023095-4dannjjm 6372 4 , , , cord-023095-4dannjjm 6372 5 we -PRON- PRP cord-023095-4dannjjm 6372 6 hypothesized hypothesize VBD cord-023095-4dannjjm 6372 7 that that IN cord-023095-4dannjjm 6372 8 B. B. NNP cord-023095-4dannjjm 6372 9 bacteriovorus bacteriovorus NNP cord-023095-4dannjjm 6372 10 can can MD cord-023095-4dannjjm 6372 11 remain remain VB cord-023095-4dannjjm 6372 12 viable viable JJ cord-023095-4dannjjm 6372 13 in in IN cord-023095-4dannjjm 6372 14 bovine bovine JJ cord-023095-4dannjjm 6372 15 tears tear NNS cord-023095-4dannjjm 6372 16 without without IN cord-023095-4dannjjm 6372 17 its -PRON- PRP$ cord-023095-4dannjjm 6372 18 prey prey NN cord-023095-4dannjjm 6372 19 for for IN cord-023095-4dannjjm 6372 20 up up IN cord-023095-4dannjjm 6372 21 to to TO cord-023095-4dannjjm 6372 22 24 24 CD cord-023095-4dannjjm 6372 23 hours hour NNS cord-023095-4dannjjm 6372 24 . . . cord-023095-4dannjjm 6373 1 This this DT cord-023095-4dannjjm 6373 2 hypothesis hypothesis NN cord-023095-4dannjjm 6373 3 was be VBD cord-023095-4dannjjm 6373 4 addressed address VBN cord-023095-4dannjjm 6373 5 by by IN cord-023095-4dannjjm 6373 6 incubating incubate VBG cord-023095-4dannjjm 6373 7 inocula inocula NN cord-023095-4dannjjm 6373 8 of of IN cord-023095-4dannjjm 6373 9 active active JJ cord-023095-4dannjjm 6373 10 B. B. NNP cord-023095-4dannjjm 6373 11 bacteriovorus bacteriovorus NNP cord-023095-4dannjjm 6373 12 in in IN cord-023095-4dannjjm 6373 13 its -PRON- PRP$ cord-023095-4dannjjm 6373 14 preferred preferred JJ cord-023095-4dannjjm 6373 15 media medium NNS cord-023095-4dannjjm 6373 16 peptone peptone NN cord-023095-4dannjjm 6373 17 yeast yeast NN cord-023095-4dannjjm 6373 18 extract extract NN cord-023095-4dannjjm 6373 19 ( ( -LRB- cord-023095-4dannjjm 6373 20 PYE PYE NNP cord-023095-4dannjjm 6373 21 ) ) -RRB- cord-023095-4dannjjm 6373 22 and and CC cord-023095-4dannjjm 6373 23 comparing compare VBG cord-023095-4dannjjm 6373 24 B. B. NNP cord-023095-4dannjjm 6373 25 bacteriovorus bacteriovorus NNP cord-023095-4dannjjm 6373 26 viability viability NN cord-023095-4dannjjm 6373 27 in in IN cord-023095-4dannjjm 6373 28 bovine bovine JJ cord-023095-4dannjjm 6373 29 tears tear NNS cord-023095-4dannjjm 6373 30 or or CC cord-023095-4dannjjm 6373 31 phosphate phosphate NN cord-023095-4dannjjm 6373 32 buffered buffer VBN cord-023095-4dannjjm 6373 33 saline saline NN cord-023095-4dannjjm 6373 34 ( ( -LRB- cord-023095-4dannjjm 6373 35 PBS PBS NNP cord-023095-4dannjjm 6373 36 ) ) -RRB- cord-023095-4dannjjm 6373 37 at at IN cord-023095-4dannjjm 6373 38 time time NN cord-023095-4dannjjm 6373 39 0 0 CD cord-023095-4dannjjm 6373 40 , , , cord-023095-4dannjjm 6373 41 2 2 CD cord-023095-4dannjjm 6373 42 , , , cord-023095-4dannjjm 6373 43 4 4 CD cord-023095-4dannjjm 6373 44 , , , cord-023095-4dannjjm 6373 45 12 12 CD cord-023095-4dannjjm 6373 46 , , , cord-023095-4dannjjm 6373 47 and and CC cord-023095-4dannjjm 6373 48 24 24 CD cord-023095-4dannjjm 6373 49 hours hour NNS cord-023095-4dannjjm 6373 50 . . . cord-023095-4dannjjm 6374 1 Using use VBG cord-023095-4dannjjm 6374 2 a a DT cord-023095-4dannjjm 6374 3 plaque plaque NN cord-023095-4dannjjm 6374 4 assay assay NN cord-023095-4dannjjm 6374 5 to to TO cord-023095-4dannjjm 6374 6 quantify quantify VB cord-023095-4dannjjm 6374 7 the the DT cord-023095-4dannjjm 6374 8 mean mean JJ cord-023095-4dannjjm 6374 9 amount amount NN cord-023095-4dannjjm 6374 10 of of IN cord-023095-4dannjjm 6374 11 plaque plaque NN cord-023095-4dannjjm 6374 12 forming form VBG cord-023095-4dannjjm 6374 13 units unit NNS cord-023095-4dannjjm 6374 14 ( ( -LRB- cord-023095-4dannjjm 6374 15 PFUs pfus NN cord-023095-4dannjjm 6374 16 ) ) -RRB- cord-023095-4dannjjm 6374 17 of of IN cord-023095-4dannjjm 6374 18 B. B. NNP cord-023095-4dannjjm 6374 19 bacteriovorus bacteriovorus NNP cord-023095-4dannjjm 6374 20 exposed expose VBN cord-023095-4dannjjm 6374 21 to to IN cord-023095-4dannjjm 6374 22 each each DT cord-023095-4dannjjm 6374 23 treatment treatment NN cord-023095-4dannjjm 6374 24 , , , cord-023095-4dannjjm 6374 25 it -PRON- PRP cord-023095-4dannjjm 6374 26 was be VBD cord-023095-4dannjjm 6374 27 determined determine VBN cord-023095-4dannjjm 6374 28 that that IN cord-023095-4dannjjm 6374 29 viability viability NN cord-023095-4dannjjm 6374 30 of of IN cord-023095-4dannjjm 6374 31 B. B. NNP cord-023095-4dannjjm 6374 32 bacteriovorus bacteriovorus NNP cord-023095-4dannjjm 6374 33 over over IN cord-023095-4dannjjm 6374 34 time time NN cord-023095-4dannjjm 6374 35 was be VBD cord-023095-4dannjjm 6374 36 comparable comparable JJ cord-023095-4dannjjm 6374 37 between between IN cord-023095-4dannjjm 6374 38 treatment treatment NN cord-023095-4dannjjm 6374 39 groups group NNS cord-023095-4dannjjm 6374 40 . . . cord-023095-4dannjjm 6375 1 Overall overall RB cord-023095-4dannjjm 6375 2 , , , cord-023095-4dannjjm 6375 3 the the DT cord-023095-4dannjjm 6375 4 results result NNS cord-023095-4dannjjm 6375 5 supported support VBD cord-023095-4dannjjm 6375 6 that that IN cord-023095-4dannjjm 6375 7 B. B. NNP cord-023095-4dannjjm 6375 8 bacteriovorus bacteriovorus NNP cord-023095-4dannjjm 6375 9 can can MD cord-023095-4dannjjm 6375 10 remain remain VB cord-023095-4dannjjm 6375 11 viable viable JJ cord-023095-4dannjjm 6375 12 in in IN cord-023095-4dannjjm 6375 13 tears tear NNS cord-023095-4dannjjm 6375 14 for for IN cord-023095-4dannjjm 6375 15 up up IN cord-023095-4dannjjm 6375 16 to to TO cord-023095-4dannjjm 6375 17 24 24 CD cord-023095-4dannjjm 6375 18 hours hour NNS cord-023095-4dannjjm 6375 19 in in IN cord-023095-4dannjjm 6375 20 the the DT cord-023095-4dannjjm 6375 21 absence absence NN cord-023095-4dannjjm 6375 22 of of IN cord-023095-4dannjjm 6375 23 prey prey NN cord-023095-4dannjjm 6375 24 bacteria bacteria NNS cord-023095-4dannjjm 6375 25 . . . cord-023095-4dannjjm 6376 1 Further further JJ cord-023095-4dannjjm 6376 2 studies study NNS cord-023095-4dannjjm 6376 3 are be VBP cord-023095-4dannjjm 6376 4 needed need VBN cord-023095-4dannjjm 6376 5 to to TO cord-023095-4dannjjm 6376 6 determine determine VB cord-023095-4dannjjm 6376 7 the the DT cord-023095-4dannjjm 6376 8 therapeutic therapeutic JJ cord-023095-4dannjjm 6376 9 potential potential NN cord-023095-4dannjjm 6376 10 of of IN cord-023095-4dannjjm 6376 11 B. B. NNP cord-023095-4dannjjm 6376 12 bacteriovorus bacteriovorus NNP cord-023095-4dannjjm 6376 13 in in IN cord-023095-4dannjjm 6376 14 an an DT cord-023095-4dannjjm 6376 15 in in IN cord-023095-4dannjjm 6376 16 vivo vivo NN cord-023095-4dannjjm 6376 17 model model NN cord-023095-4dannjjm 6376 18 of of IN cord-023095-4dannjjm 6376 19 IBK IBK NNP cord-023095-4dannjjm 6376 20 . . . cord-023095-4dannjjm 6377 1 Correction correction NN cord-023095-4dannjjm 6377 2 of of IN cord-023095-4dannjjm 6377 3 the the DT cord-023095-4dannjjm 6377 4 measured measure VBN cord-023095-4dannjjm 6377 5 ionized ionized JJ cord-023095-4dannjjm 6377 6 calcium calcium NN cord-023095-4dannjjm 6377 7 concentration concentration NN cord-023095-4dannjjm 6377 8 ( ( -LRB- cord-023095-4dannjjm 6377 9 cCa cCa NNP cord-023095-4dannjjm 6377 10 21 21 CD cord-023095-4dannjjm 6377 11 ) ) -RRB- cord-023095-4dannjjm 6377 12 to to IN cord-023095-4dannjjm 6377 13 a a DT cord-023095-4dannjjm 6377 14 pH pH NNP cord-023095-4dannjjm 6377 15 5 5 CD cord-023095-4dannjjm 6377 16 7.40 7.40 CD cord-023095-4dannjjm 6377 17 is be VBZ cord-023095-4dannjjm 6377 18 routinely routinely RB cord-023095-4dannjjm 6377 19 applied apply VBN cord-023095-4dannjjm 6377 20 in in IN cord-023095-4dannjjm 6377 21 experimental experimental JJ cord-023095-4dannjjm 6377 22 studies study NNS cord-023095-4dannjjm 6377 23 in in IN cord-023095-4dannjjm 6377 24 order order NN cord-023095-4dannjjm 6377 25 to to TO cord-023095-4dannjjm 6377 26 assist assist VB cord-023095-4dannjjm 6377 27 in in IN cord-023095-4dannjjm 6377 28 the the DT cord-023095-4dannjjm 6377 29 interpretation interpretation NN cord-023095-4dannjjm 6377 30 of of IN cord-023095-4dannjjm 6377 31 measured measure VBN cord-023095-4dannjjm 6377 32 values value NNS cord-023095-4dannjjm 6377 33 relative relative JJ cord-023095-4dannjjm 6377 34 to to IN cord-023095-4dannjjm 6377 35 a a DT cord-023095-4dannjjm 6377 36 reference reference NN cord-023095-4dannjjm 6377 37 range range NN cord-023095-4dannjjm 6377 38 . . . cord-023095-4dannjjm 6378 1 The the DT cord-023095-4dannjjm 6378 2 equation equation NN cord-023095-4dannjjm 6378 3 most most RBS cord-023095-4dannjjm 6378 4 commonly commonly RB cord-023095-4dannjjm 6378 5 used use VBN cord-023095-4dannjjm 6378 6 for for IN cord-023095-4dannjjm 6378 7 pH ph NN cord-023095-4dannjjm 6378 8 correction correction NN cord-023095-4dannjjm 6378 9 in in IN cord-023095-4dannjjm 6378 10 bovine bovine JJ cord-023095-4dannjjm 6378 11 plasma plasma NN cord-023095-4dannjjm 6378 12 is be VBZ cord-023095-4dannjjm 6378 13 : : : cord-023095-4dannjjm 6378 14 cCa cCa NNS cord-023095-4dannjjm 6378 15 21 21 CD cord-023095-4dannjjm 6378 16 pH ph NN cord-023095-4dannjjm 6378 17 5 5 CD cord-023095-4dannjjm 6379 1 7.40 7.40 CD cord-023095-4dannjjm 6379 2 5 5 CD cord-023095-4dannjjm 6379 3 cCa cCa NNS cord-023095-4dannjjm 6379 4 21 21 CD cord-023095-4dannjjm 6379 5 Â10 Â10 NNP cord-023095-4dannjjm 6379 6 ( ( -LRB- cord-023095-4dannjjm 6379 7 -0.24Â{7.40 -0.24Â{7.40 : cord-023095-4dannjjm 6379 8 -pH -ph JJ cord-023095-4dannjjm 6379 9 } } -RRB- cord-023095-4dannjjm 6379 10 ) ) -RRB- cord-023095-4dannjjm 6379 11 . . . cord-023095-4dannjjm 6380 1 The the DT cord-023095-4dannjjm 6380 2 validity validity NN cord-023095-4dannjjm 6380 3 of of IN cord-023095-4dannjjm 6380 4 this this DT cord-023095-4dannjjm 6380 5 equation equation NN cord-023095-4dannjjm 6380 6 for for IN cord-023095-4dannjjm 6380 7 bovine bovine JJ cord-023095-4dannjjm 6380 8 plasma plasma NN cord-023095-4dannjjm 6380 9 is be VBZ cord-023095-4dannjjm 6380 10 unknown unknown JJ cord-023095-4dannjjm 6380 11 . . . cord-023095-4dannjjm 6381 1 Accordingly accordingly RB cord-023095-4dannjjm 6381 2 , , , cord-023095-4dannjjm 6381 3 our -PRON- PRP$ cord-023095-4dannjjm 6381 4 first first JJ cord-023095-4dannjjm 6381 5 objective objective NN cord-023095-4dannjjm 6381 6 was be VBD cord-023095-4dannjjm 6381 7 to to TO cord-023095-4dannjjm 6381 8 characterize characterize VB cord-023095-4dannjjm 6381 9 the the DT cord-023095-4dannjjm 6381 10 in in FW cord-023095-4dannjjm 6381 11 vitro vitro FW cord-023095-4dannjjm 6381 12 relationship relationship NN cord-023095-4dannjjm 6381 13 between between IN cord-023095-4dannjjm 6381 14 cCa cCa NNS cord-023095-4dannjjm 6381 15 21 21 CD cord-023095-4dannjjm 6381 16 and and CC cord-023095-4dannjjm 6381 17 pH ph NN cord-023095-4dannjjm 6381 18 for for IN cord-023095-4dannjjm 6381 19 bovine bovine JJ cord-023095-4dannjjm 6381 20 plasma plasma NN cord-023095-4dannjjm 6381 21 . . . cord-023095-4dannjjm 6382 1 Feeding feed VBG cord-023095-4dannjjm 6382 2 rations ration NNS cord-023095-4dannjjm 6382 3 with with IN cord-023095-4dannjjm 6382 4 a a DT cord-023095-4dannjjm 6382 5 low low JJ cord-023095-4dannjjm 6382 6 dietary dietary JJ cord-023095-4dannjjm 6382 7 cation cation NN cord-023095-4dannjjm 6382 8 - - HYPH cord-023095-4dannjjm 6382 9 anion anion NN cord-023095-4dannjjm 6382 10 difference difference NN cord-023095-4dannjjm 6382 11 ( ( -LRB- cord-023095-4dannjjm 6382 12 DCAD DCAD NNP cord-023095-4dannjjm 6382 13 ) ) -RRB- cord-023095-4dannjjm 6382 14 during during IN cord-023095-4dannjjm 6382 15 late late JJ cord-023095-4dannjjm 6382 16 gestation gestation NN cord-023095-4dannjjm 6382 17 mitigates mitigate VBZ cord-023095-4dannjjm 6382 18 periparturient periparturient NN cord-023095-4dannjjm 6382 19 hypocalcemia hypocalcemia NN cord-023095-4dannjjm 6382 20 in in IN cord-023095-4dannjjm 6382 21 dairy dairy NN cord-023095-4dannjjm 6382 22 cows cow NNS cord-023095-4dannjjm 6382 23 , , , cord-023095-4dannjjm 6382 24 particularly particularly RB cord-023095-4dannjjm 6382 25 when when WRB cord-023095-4dannjjm 6382 26 chloride chloride NN cord-023095-4dannjjm 6382 27 containing contain VBG cord-023095-4dannjjm 6382 28 acidodgenic acidodgenic JJ cord-023095-4dannjjm 6382 29 salts salt NNS cord-023095-4dannjjm 6382 30 are be VBP cord-023095-4dannjjm 6382 31 fed feed VBN cord-023095-4dannjjm 6382 32 . . . cord-023095-4dannjjm 6383 1 The the DT cord-023095-4dannjjm 6383 2 mechanism mechanism NN cord-023095-4dannjjm 6383 3 for for IN cord-023095-4dannjjm 6383 4 this this DT cord-023095-4dannjjm 6383 5 beneficial beneficial JJ cord-023095-4dannjjm 6383 6 effect effect NN cord-023095-4dannjjm 6383 7 remains remain VBZ cord-023095-4dannjjm 6383 8 unclear unclear JJ cord-023095-4dannjjm 6383 9 . . . cord-023095-4dannjjm 6384 1 Our -PRON- PRP$ cord-023095-4dannjjm 6384 2 second second JJ cord-023095-4dannjjm 6384 3 objective objective NN cord-023095-4dannjjm 6384 4 was be VBD cord-023095-4dannjjm 6384 5 to to TO cord-023095-4dannjjm 6384 6 determine determine VB cord-023095-4dannjjm 6384 7 whether whether IN cord-023095-4dannjjm 6384 8 hyperchloremia hyperchloremia NN cord-023095-4dannjjm 6384 9 displaces displace VBZ cord-023095-4dannjjm 6384 10 calcium calcium NN cord-023095-4dannjjm 6384 11 from from IN cord-023095-4dannjjm 6384 12 binding bind VBG cord-023095-4dannjjm 6384 13 sites site NNS cord-023095-4dannjjm 6384 14 to to IN cord-023095-4dannjjm 6384 15 albumin albumin NN cord-023095-4dannjjm 6384 16 , , , cord-023095-4dannjjm 6384 17 thereby thereby RB cord-023095-4dannjjm 6384 18 increasing increase VBG cord-023095-4dannjjm 6384 19 cCa cCa NNS cord-023095-4dannjjm 6384 20 21 21 CD cord-023095-4dannjjm 6384 21 . . . cord-023095-4dannjjm 6385 1 The the DT cord-023095-4dannjjm 6385 2 in in FW cord-023095-4dannjjm 6385 3 vitro vitro FW cord-023095-4dannjjm 6385 4 relationship relationship NN cord-023095-4dannjjm 6385 5 between between IN cord-023095-4dannjjm 6385 6 plasma plasma NN cord-023095-4dannjjm 6385 7 log(cCa log(cCa NNP cord-023095-4dannjjm 6385 8 21 21 CD cord-023095-4dannjjm 6385 9 ) ) -RRB- cord-023095-4dannjjm 6385 10 and and CC cord-023095-4dannjjm 6385 11 pH pH NNP cord-023095-4dannjjm 6386 1 in in IN cord-023095-4dannjjm 6386 2 was be VBD cord-023095-4dannjjm 6386 3 investigated investigate VBN cord-023095-4dannjjm 6386 4 using use VBG cord-023095-4dannjjm 6386 5 lithium lithium NN cord-023095-4dannjjm 6386 6 heparin heparin NN cord-023095-4dannjjm 6386 7 anticoagulated anticoagulate VBD cord-023095-4dannjjm 6386 8 blood blood NN cord-023095-4dannjjm 6386 9 from from IN cord-023095-4dannjjm 6386 10 10 10 CD cord-023095-4dannjjm 6386 11 healthy healthy JJ cord-023095-4dannjjm 6386 12 Holstein Holstein NNP cord-023095-4dannjjm 6386 13 - - HYPH cord-023095-4dannjjm 6386 14 Friesian friesian JJ cord-023095-4dannjjm 6386 15 calves calf NNS cord-023095-4dannjjm 6386 16 . . . cord-023095-4dannjjm 6387 1 Plasma plasma NN cord-023095-4dannjjm 6387 2 was be VBD cord-023095-4dannjjm 6387 3 harvested harvest VBN cord-023095-4dannjjm 6387 4 and and CC cord-023095-4dannjjm 6387 5 tonometered tonometere VBN cord-023095-4dannjjm 6387 6 with with IN cord-023095-4dannjjm 6387 7 CO CO NNP cord-023095-4dannjjm 6387 8 2 2 CD cord-023095-4dannjjm 6387 9 at at IN cord-023095-4dannjjm 6387 10 371C 371c CD cord-023095-4dannjjm 6387 11 over over IN cord-023095-4dannjjm 6387 12 a a DT cord-023095-4dannjjm 6387 13 pH pH NNP cord-023095-4dannjjm 6387 14 range range NN cord-023095-4dannjjm 6387 15 of of IN cord-023095-4dannjjm 6387 16 7.10 7.10 CD cord-023095-4dannjjm 6387 17 - - HYPH cord-023095-4dannjjm 6387 18 7.70 7.70 CD cord-023095-4dannjjm 6387 19 . . . cord-023095-4dannjjm 6388 1 Plasma plasma NN cord-023095-4dannjjm 6388 2 chloride chloride NN cord-023095-4dannjjm 6388 3 concentration concentration NN cord-023095-4dannjjm 6388 4 ( ( -LRB- cord-023095-4dannjjm 6388 5 cCl cCl NNS cord-023095-4dannjjm 6388 6 - - , cord-023095-4dannjjm 6388 7 ) ) -RRB- cord-023095-4dannjjm 6388 8 was be VBD cord-023095-4dannjjm 6388 9 altered alter VBN cord-023095-4dannjjm 6388 10 by by IN cord-023095-4dannjjm 6388 11 equivolume equivolume NNP cord-023095-4dannjjm 6388 12 dilution dilution NN cord-023095-4dannjjm 6388 13 of of IN cord-023095-4dannjjm 6388 14 plasma plasma NN cord-023095-4dannjjm 6388 15 with with IN cord-023095-4dannjjm 6388 16 3 3 CD cord-023095-4dannjjm 6388 17 electrolyte electrolyte JJ cord-023095-4dannjjm 6388 18 solutions solution NNS cord-023095-4dannjjm 6388 19 of of IN cord-023095-4dannjjm 6388 20 varying vary VBG cord-023095-4dannjjm 6388 21 cCl cCl NNS cord-023095-4dannjjm 6388 22 -(97 -(97 IN cord-023095-4dannjjm 6388 23 AE AE NNP cord-023095-4dannjjm 6388 24 1 1 CD cord-023095-4dannjjm 6388 25 , , , cord-023095-4dannjjm 6388 26 110 110 CD cord-023095-4dannjjm 6388 27 AE AE NNP cord-023095-4dannjjm 6388 28 1 1 CD cord-023095-4dannjjm 6388 29 , , , cord-023095-4dannjjm 6388 30 and and CC cord-023095-4dannjjm 6388 31 123 123 CD cord-023095-4dannjjm 6388 32 AE ae NN cord-023095-4dannjjm 6388 33 1 1 CD cord-023095-4dannjjm 6388 34 mEq mEq NNS cord-023095-4dannjjm 6388 35 / / SYM cord-023095-4dannjjm 6388 36 L l NN cord-023095-4dannjjm 6388 37 ; ; : cord-023095-4dannjjm 6388 38 mean mean VB cord-023095-4dannjjm 6388 39 AE AE NNP cord-023095-4dannjjm 6388 40 SD SD NNP cord-023095-4dannjjm 6388 41 ) ) -RRB- cord-023095-4dannjjm 6388 42 . . . cord-023095-4dannjjm 6389 1 The the DT cord-023095-4dannjjm 6389 2 slope slope NN cord-023095-4dannjjm 6389 3 of of IN cord-023095-4dannjjm 6389 4 the the DT cord-023095-4dannjjm 6389 5 linear linear JJ cord-023095-4dannjjm 6389 6 regression regression NN cord-023095-4dannjjm 6389 7 equation equation NN cord-023095-4dannjjm 6389 8 relating relate VBG cord-023095-4dannjjm 6389 9 log(cCa log(cCa NNP cord-023095-4dannjjm 6389 10 21 21 CD cord-023095-4dannjjm 6389 11 ) ) -RRB- cord-023095-4dannjjm 6389 12 to to IN cord-023095-4dannjjm 6389 13 pH pH NNP cord-023095-4dannjjm 6389 14 for for IN cord-023095-4dannjjm 6389 15 112 112 CD cord-023095-4dannjjm 6389 16 tonometered tonometere VBN cord-023095-4dannjjm 6389 17 plasma plasma NN cord-023095-4dannjjm 6389 18 samples sample NNS cord-023095-4dannjjm 6389 19 from from IN cord-023095-4dannjjm 6389 20 the the DT cord-023095-4dannjjm 6389 21 10 10 CD cord-023095-4dannjjm 6389 22 calves calf NNS cord-023095-4dannjjm 6389 23 was be VBD cord-023095-4dannjjm 6389 24 -0.24 -0.24 CD cord-023095-4dannjjm 6389 25 AE AE NNP cord-023095-4dannjjm 6389 26 0.05 0.05 CD cord-023095-4dannjjm 6389 27 at at IN cord-023095-4dannjjm 6389 28 normal normal JJ cord-023095-4dannjjm 6389 29 values value NNS cord-023095-4dannjjm 6389 30 for for IN cord-023095-4dannjjm 6389 31 cCa cCa NNS cord-023095-4dannjjm 6389 32 21 21 CD cord-023095-4dannjjm 6389 33 ( ( -LRB- cord-023095-4dannjjm 6389 34 2.63 2.63 CD cord-023095-4dannjjm 6389 35 AE AE NNP cord-023095-4dannjjm 6389 36 0.09 0.09 CD cord-023095-4dannjjm 6389 37 mEq mEq NNS cord-023095-4dannjjm 6389 38 / / SYM cord-023095-4dannjjm 6389 39 L L NNP cord-023095-4dannjjm 6389 40 ) ) -RRB- cord-023095-4dannjjm 6389 41 , , , cord-023095-4dannjjm 6389 42 albumin albumin NN cord-023095-4dannjjm 6389 43 concentration concentration NN cord-023095-4dannjjm 6389 44 ( ( -LRB- cord-023095-4dannjjm 6389 45 30.9 30.9 CD cord-023095-4dannjjm 6389 46 AE AE NNP cord-023095-4dannjjm 6389 47 2.0 2.0 CD cord-023095-4dannjjm 6389 48 g g NN cord-023095-4dannjjm 6389 49 / / SYM cord-023095-4dannjjm 6389 50 L L NNP cord-023095-4dannjjm 6389 51 ) ) -RRB- cord-023095-4dannjjm 6389 52 , , , cord-023095-4dannjjm 6389 53 and and CC cord-023095-4dannjjm 6389 54 cCl cCl NNS cord-023095-4dannjjm 6389 55 -(99.1 -(99.1 : cord-023095-4dannjjm 6389 56 AE AE NNP cord-023095-4dannjjm 6389 57 2.2 2.2 CD cord-023095-4dannjjm 6389 58 mEq mEq NNS cord-023095-4dannjjm 6389 59 / / SYM cord-023095-4dannjjm 6389 60 L L NNP cord-023095-4dannjjm 6389 61 ) ) -RRB- cord-023095-4dannjjm 6389 62 . . . cord-023095-4dannjjm 6390 1 The the DT cord-023095-4dannjjm 6390 2 experimentally experimentally RB cord-023095-4dannjjm 6390 3 - - HYPH cord-023095-4dannjjm 6390 4 determined determine VBN cord-023095-4dannjjm 6390 5 value value NN cord-023095-4dannjjm 6390 6 for for IN cord-023095-4dannjjm 6390 7 the the DT cord-023095-4dannjjm 6390 8 slope slope NN cord-023095-4dannjjm 6390 9 for for IN cord-023095-4dannjjm 6390 10 bovine bovine JJ cord-023095-4dannjjm 6390 11 plasma plasma NN cord-023095-4dannjjm 6390 12 was be VBD cord-023095-4dannjjm 6390 13 identical identical JJ cord-023095-4dannjjm 6390 14 to to IN cord-023095-4dannjjm 6390 15 that that DT cord-023095-4dannjjm 6390 16 determined determine VBN cord-023095-4dannjjm 6390 17 previously previously RB cord-023095-4dannjjm 6390 18 for for IN cord-023095-4dannjjm 6390 19 human human JJ cord-023095-4dannjjm 6390 20 plasma plasma NN cord-023095-4dannjjm 6390 21 . . . cord-023095-4dannjjm 6391 1 The the DT cord-023095-4dannjjm 6391 2 formula formula NN cord-023095-4dannjjm 6391 3 for for IN cord-023095-4dannjjm 6391 4 correcting correct VBG cord-023095-4dannjjm 6391 5 cCa cCa NNS cord-023095-4dannjjm 6391 6 21 21 CD cord-023095-4dannjjm 6391 7 in in IN cord-023095-4dannjjm 6391 8 bovine bovine JJ cord-023095-4dannjjm 6391 9 plasma plasma NN cord-023095-4dannjjm 6391 10 for for IN cord-023095-4dannjjm 6391 11 change change NN cord-023095-4dannjjm 6391 12 in in IN cord-023095-4dannjjm 6391 13 pH pH NNP cord-023095-4dannjjm 6391 14 from from IN cord-023095-4dannjjm 6391 15 7.40 7.40 CD cord-023095-4dannjjm 6391 16 is be VBZ cord-023095-4dannjjm 6391 17 therefore therefore RB cord-023095-4dannjjm 6391 18 : : : cord-023095-4dannjjm 6391 19 cCa cCa NNS cord-023095-4dannjjm 6391 20 21 21 CD cord-023095-4dannjjm 6391 21 pH pH NNP cord-023095-4dannjjm 6391 22 5 5 CD cord-023095-4dannjjm 6391 23 7.40 7.40 CD cord-023095-4dannjjm 6391 24 5 5 CD cord-023095-4dannjjm 6392 1 cCa cCa NNP cord-023095-4dannjjm 6392 2 21 21 CD cord-023095-4dannjjm 6392 3 Â â CD cord-023095-4dannjjm 6392 4 10 10 CD cord-023095-4dannjjm 6393 1 ( ( -LRB- cord-023095-4dannjjm 6393 2 À à NN cord-023095-4dannjjm 6393 3 0.24 0.24 CD cord-023095-4dannjjm 6393 4 Â â NN cord-023095-4dannjjm 6393 5 { { -LRB- cord-023095-4dannjjm 6393 6 7.40-pH 7.40-ph CD cord-023095-4dannjjm 6393 7 } } -RRB- cord-023095-4dannjjm 6393 8 ) ) -RRB- cord-023095-4dannjjm 6393 9 . . . cord-023095-4dannjjm 6394 1 This this DT cord-023095-4dannjjm 6394 2 equation equation NN cord-023095-4dannjjm 6394 3 is be VBZ cord-023095-4dannjjm 6394 4 only only RB cord-023095-4dannjjm 6394 5 valid valid JJ cord-023095-4dannjjm 6394 6 at at IN cord-023095-4dannjjm 6394 7 normal normal JJ cord-023095-4dannjjm 6394 8 concentrations concentration NNS cord-023095-4dannjjm 6394 9 of of IN cord-023095-4dannjjm 6394 10 albumin albumin NN cord-023095-4dannjjm 6394 11 and and CC cord-023095-4dannjjm 6394 12 chloride chloride NN cord-023095-4dannjjm 6394 13 in in IN cord-023095-4dannjjm 6394 14 plasma plasma NN cord-023095-4dannjjm 6394 15 . . . cord-023095-4dannjjm 6395 1 Equivolume equivolume NN cord-023095-4dannjjm 6395 2 dilution dilution NN cord-023095-4dannjjm 6395 3 of of IN cord-023095-4dannjjm 6395 4 plasma plasma NN cord-023095-4dannjjm 6395 5 by by IN cord-023095-4dannjjm 6395 6 electrolyte electrolyte JJ cord-023095-4dannjjm 6395 7 solutions solution NNS cord-023095-4dannjjm 6395 8 of of IN cord-023095-4dannjjm 6395 9 varying vary VBG cord-023095-4dannjjm 6395 10 cClindicated cClindicated NNP cord-023095-4dannjjm 6395 11 that that IN cord-023095-4dannjjm 6395 12 cCa cCa VBZ cord-023095-4dannjjm 6395 13 21 21 CD cord-023095-4dannjjm 6395 14 pH pH NNP cord-023095-4dannjjm 6395 15 5 5 CD cord-023095-4dannjjm 6395 16 7.40 7.40 CD cord-023095-4dannjjm 6395 17 increased increase VBN cord-023095-4dannjjm 6395 18 by by IN cord-023095-4dannjjm 6395 19 0.007 0.007 CD cord-023095-4dannjjm 6395 20 mEq mEq NNS cord-023095-4dannjjm 6395 21 for for IN cord-023095-4dannjjm 6395 22 every every DT cord-023095-4dannjjm 6395 23 1 1 CD cord-023095-4dannjjm 6395 24 mEq mEq NNS cord-023095-4dannjjm 6395 25 / / SYM cord-023095-4dannjjm 6395 26 L L NNP cord-023095-4dannjjm 6395 27 increase increase NN cord-023095-4dannjjm 6395 28 in in IN cord-023095-4dannjjm 6395 29 cCl cCl NNS cord-023095-4dannjjm 6395 30 - - , cord-023095-4dannjjm 6395 31 . . . cord-023095-4dannjjm 6396 1 In in IN cord-023095-4dannjjm 6396 2 other other JJ cord-023095-4dannjjm 6396 3 words word NNS cord-023095-4dannjjm 6396 4 , , , cord-023095-4dannjjm 6396 5 plasma plasma NN cord-023095-4dannjjm 6396 6 cCa cCa NNS cord-023095-4dannjjm 6396 7 21 21 CD cord-023095-4dannjjm 6396 8 at at IN cord-023095-4dannjjm 6396 9 a a DT cord-023095-4dannjjm 6396 10 given give VBN cord-023095-4dannjjm 6396 11 pH ph NN cord-023095-4dannjjm 6396 12 increases increase NNS cord-023095-4dannjjm 6396 13 directly directly RB cord-023095-4dannjjm 6396 14 in in IN cord-023095-4dannjjm 6396 15 response response NN cord-023095-4dannjjm 6396 16 to to IN cord-023095-4dannjjm 6396 17 an an DT cord-023095-4dannjjm 6396 18 increase increase NN cord-023095-4dannjjm 6396 19 in in IN cord-023095-4dannjjm 6396 20 plasma plasma NN cord-023095-4dannjjm 6396 21 cCl cCl NNS cord-023095-4dannjjm 6396 22 - - : cord-023095-4dannjjm 6396 23 , , , cord-023095-4dannjjm 6396 24 presumably presumably RB cord-023095-4dannjjm 6396 25 because because IN cord-023095-4dannjjm 6396 26 the the DT cord-023095-4dannjjm 6396 27 additional additional JJ cord-023095-4dannjjm 6396 28 chloride chloride NN cord-023095-4dannjjm 6396 29 displaces displace VBZ cord-023095-4dannjjm 6396 30 calcium calcium NN cord-023095-4dannjjm 6396 31 that that WDT cord-023095-4dannjjm 6396 32 is be VBZ cord-023095-4dannjjm 6396 33 electrostatically electrostatically RB cord-023095-4dannjjm 6396 34 bound bind VBN cord-023095-4dannjjm 6396 35 to to IN cord-023095-4dannjjm 6396 36 albumin albumin NN cord-023095-4dannjjm 6396 37 . . . cord-023095-4dannjjm 6397 1 Furthermore furthermore RB cord-023095-4dannjjm 6397 2 , , , cord-023095-4dannjjm 6397 3 the the DT cord-023095-4dannjjm 6397 4 increase increase NN cord-023095-4dannjjm 6397 5 in in IN cord-023095-4dannjjm 6397 6 cCa cCa NNS cord-023095-4dannjjm 6397 7 21 21 CD cord-023095-4dannjjm 6397 8 is be VBZ cord-023095-4dannjjm 6397 9 independent independent JJ cord-023095-4dannjjm 6397 10 to to IN cord-023095-4dannjjm 6397 11 the the DT cord-023095-4dannjjm 6397 12 change change NN cord-023095-4dannjjm 6397 13 in in IN cord-023095-4dannjjm 6397 14 plasma plasma NN cord-023095-4dannjjm 6397 15 pH ph NN cord-023095-4dannjjm 6397 16 induced induce VBN cord-023095-4dannjjm 6397 17 by by IN cord-023095-4dannjjm 6397 18 an an DT cord-023095-4dannjjm 6397 19 increase increase NN cord-023095-4dannjjm 6397 20 in in IN cord-023095-4dannjjm 6397 21 cCland cCland NNP cord-023095-4dannjjm 6397 22 decrease decrease NN cord-023095-4dannjjm 6397 23 in in IN cord-023095-4dannjjm 6397 24 plasma plasma NN cord-023095-4dannjjm 6397 25 strong strong JJ cord-023095-4dannjjm 6397 26 ion ion NN cord-023095-4dannjjm 6397 27 difference difference NN cord-023095-4dannjjm 6397 28 . . . cord-023095-4dannjjm 6398 1 Our -PRON- PRP$ cord-023095-4dannjjm 6398 2 finding finding NN cord-023095-4dannjjm 6398 3 that that IN cord-023095-4dannjjm 6398 4 hyperchloremia hyperchloremia NN cord-023095-4dannjjm 6398 5 directly directly RB cord-023095-4dannjjm 6398 6 increases increase VBZ cord-023095-4dannjjm 6398 7 plasma plasma NN cord-023095-4dannjjm 6398 8 cCa cCa NNP cord-023095-4dannjjm 6398 9 21 21 CD cord-023095-4dannjjm 6398 10 provides provide VBZ cord-023095-4dannjjm 6398 11 an an DT cord-023095-4dannjjm 6398 12 additional additional JJ cord-023095-4dannjjm 6398 13 mechanism mechanism NN cord-023095-4dannjjm 6398 14 by by IN cord-023095-4dannjjm 6398 15 which which WDT cord-023095-4dannjjm 6398 16 ingestion ingestion NN cord-023095-4dannjjm 6398 17 of of IN cord-023095-4dannjjm 6398 18 high high JJ cord-023095-4dannjjm 6398 19 chloride chloride NN cord-023095-4dannjjm 6398 20 ( ( -LRB- cord-023095-4dannjjm 6398 21 acidogenic acidogenic NNP cord-023095-4dannjjm 6398 22 ) ) -RRB- cord-023095-4dannjjm 6398 23 rations ration NNS cord-023095-4dannjjm 6398 24 prevents prevent VBZ cord-023095-4dannjjm 6398 25 the the DT cord-023095-4dannjjm 6398 26 clinical clinical JJ cord-023095-4dannjjm 6398 27 signs sign NNS cord-023095-4dannjjm 6398 28 of of IN cord-023095-4dannjjm 6398 29 periparturient periparturient NN cord-023095-4dannjjm 6398 30 paresis paresis NNP cord-023095-4dannjjm 6398 31 . . . cord-023095-4dannjjm 6399 1 Our -PRON- PRP$ cord-023095-4dannjjm 6399 2 finding finding NN cord-023095-4dannjjm 6399 3 is be VBZ cord-023095-4dannjjm 6399 4 consistent consistent JJ cord-023095-4dannjjm 6399 5 with with IN cord-023095-4dannjjm 6399 6 the the DT cord-023095-4dannjjm 6399 7 results result NNS cord-023095-4dannjjm 6399 8 of of IN cord-023095-4dannjjm 6399 9 other other JJ cord-023095-4dannjjm 6399 10 studies study NNS cord-023095-4dannjjm 6399 11 that that WDT cord-023095-4dannjjm 6399 12 indicate indicate VBP cord-023095-4dannjjm 6399 13 acidogenic acidogenic JJ cord-023095-4dannjjm 6399 14 salts salt NNS cord-023095-4dannjjm 6399 15 that that WDT cord-023095-4dannjjm 6399 16 contain contain VBP cord-023095-4dannjjm 6399 17 chloride chloride NN cord-023095-4dannjjm 6399 18 as as IN cord-023095-4dannjjm 6399 19 the the DT cord-023095-4dannjjm 6399 20 predominant predominant JJ cord-023095-4dannjjm 6399 21 anion anion NN cord-023095-4dannjjm 6399 22 ( ( -LRB- cord-023095-4dannjjm 6399 23 ie ie NNP cord-023095-4dannjjm 6399 24 , , , cord-023095-4dannjjm 6399 25 NH NH NNP cord-023095-4dannjjm 6399 26 4 4 CD cord-023095-4dannjjm 6399 27 Cl Cl NNP cord-023095-4dannjjm 6399 28 , , , cord-023095-4dannjjm 6399 29 CaCl CaCl NNP cord-023095-4dannjjm 6399 30 2 2 CD cord-023095-4dannjjm 6399 31 ) ) -RRB- cord-023095-4dannjjm 6399 32 are be VBP cord-023095-4dannjjm 6399 33 more more RBR cord-023095-4dannjjm 6399 34 effective effective JJ cord-023095-4dannjjm 6399 35 in in IN cord-023095-4dannjjm 6399 36 increasing increase VBG cord-023095-4dannjjm 6399 37 cCa cCa NNS cord-023095-4dannjjm 6399 38 21 21 CD cord-023095-4dannjjm 6399 39 than than IN cord-023095-4dannjjm 6399 40 equimolar equimolar JJ cord-023095-4dannjjm 6399 41 quantities quantity NNS cord-023095-4dannjjm 6399 42 of of IN cord-023095-4dannjjm 6399 43 acidogenic acidogenic NNP cord-023095-4dannjjm 6399 44 salts salt NNS cord-023095-4dannjjm 6399 45 such such JJ cord-023095-4dannjjm 6399 46 as as IN cord-023095-4dannjjm 6399 47 MgSO MgSO NNP cord-023095-4dannjjm 6399 48 4 4 CD cord-023095-4dannjjm 6399 49 . . . cord-023095-4dannjjm 6400 1 Coagulase coagulase JJ cord-023095-4dannjjm 6400 2 negative negative JJ cord-023095-4dannjjm 6400 3 staphylococci staphylococcus NNS cord-023095-4dannjjm 6400 4 ( ( -LRB- cord-023095-4dannjjm 6400 5 CNS CNS NNP cord-023095-4dannjjm 6400 6 ) ) -RRB- cord-023095-4dannjjm 6400 7 are be VBP cord-023095-4dannjjm 6400 8 among among IN cord-023095-4dannjjm 6400 9 the the DT cord-023095-4dannjjm 6400 10 most most RBS cord-023095-4dannjjm 6400 11 common common JJ cord-023095-4dannjjm 6400 12 bacteria bacteria NNS cord-023095-4dannjjm 6400 13 isolated isolate VBN cord-023095-4dannjjm 6400 14 from from IN cord-023095-4dannjjm 6400 15 the the DT cord-023095-4dannjjm 6400 16 bovine bovine JJ cord-023095-4dannjjm 6400 17 mammary mammary JJ cord-023095-4dannjjm 6400 18 gland gland NN cord-023095-4dannjjm 6400 19 . . . cord-023095-4dannjjm 6401 1 Historically historically RB cord-023095-4dannjjm 6401 2 , , , cord-023095-4dannjjm 6401 3 these these DT cord-023095-4dannjjm 6401 4 bacteria bacteria NNS cord-023095-4dannjjm 6401 5 were be VBD cord-023095-4dannjjm 6401 6 lumped lump VBN cord-023095-4dannjjm 6401 7 together together RB cord-023095-4dannjjm 6401 8 as as IN cord-023095-4dannjjm 6401 9 minor minor JJ cord-023095-4dannjjm 6401 10 mastitis mastitis NN cord-023095-4dannjjm 6401 11 pathogens pathogen NNS cord-023095-4dannjjm 6401 12 . . . cord-023095-4dannjjm 6402 1 Modern modern JJ cord-023095-4dannjjm 6402 2 molecular molecular JJ cord-023095-4dannjjm 6402 3 techniques technique NNS cord-023095-4dannjjm 6402 4 have have VBP cord-023095-4dannjjm 6402 5 allowed allow VBN cord-023095-4dannjjm 6402 6 accurate accurate JJ cord-023095-4dannjjm 6402 7 speciation speciation NN cord-023095-4dannjjm 6402 8 and and CC cord-023095-4dannjjm 6402 9 fingerprinting fingerprinting NN cord-023095-4dannjjm 6402 10 of of IN cord-023095-4dannjjm 6402 11 the the DT cord-023095-4dannjjm 6402 12 CNS CNS NNP cord-023095-4dannjjm 6402 13 species specie NNS cord-023095-4dannjjm 6402 14 . . . cord-023095-4dannjjm 6403 1 These these DT cord-023095-4dannjjm 6403 2 methodologies methodology NNS cord-023095-4dannjjm 6403 3 have have VBP cord-023095-4dannjjm 6403 4 recently recently RB cord-023095-4dannjjm 6403 5 been be VBN cord-023095-4dannjjm 6403 6 applied apply VBN cord-023095-4dannjjm 6403 7 to to IN cord-023095-4dannjjm 6403 8 the the DT cord-023095-4dannjjm 6403 9 study study NN cord-023095-4dannjjm 6403 10 of of IN cord-023095-4dannjjm 6403 11 CNS CNS NNP cord-023095-4dannjjm 6403 12 in in IN cord-023095-4dannjjm 6403 13 bovine bovine JJ cord-023095-4dannjjm 6403 14 mastitis mastitis NN cord-023095-4dannjjm 6403 15 . . . cord-023095-4dannjjm 6404 1 The the DT cord-023095-4dannjjm 6404 2 aim aim NN cord-023095-4dannjjm 6404 3 of of IN cord-023095-4dannjjm 6404 4 the the DT cord-023095-4dannjjm 6404 5 studies study NNS cord-023095-4dannjjm 6404 6 presented present VBN cord-023095-4dannjjm 6404 7 here here RB cord-023095-4dannjjm 6404 8 was be VBD cord-023095-4dannjjm 6404 9 to to TO cord-023095-4dannjjm 6404 10 evaluate evaluate VB cord-023095-4dannjjm 6404 11 the the DT cord-023095-4dannjjm 6404 12 role role NN cord-023095-4dannjjm 6404 13 of of IN cord-023095-4dannjjm 6404 14 individual individual JJ cord-023095-4dannjjm 6404 15 CNS CNS NNP cord-023095-4dannjjm 6404 16 species specie NNS cord-023095-4dannjjm 6404 17 on on IN cord-023095-4dannjjm 6404 18 milk milk NN cord-023095-4dannjjm 6404 19 somatic somatic JJ cord-023095-4dannjjm 6404 20 cell cell NN cord-023095-4dannjjm 6404 21 count count NN cord-023095-4dannjjm 6404 22 ( ( -LRB- cord-023095-4dannjjm 6404 23 SCC SCC NNP cord-023095-4dannjjm 6404 24 ) ) -RRB- cord-023095-4dannjjm 6404 25 and and CC cord-023095-4dannjjm 6404 26 duration duration NN cord-023095-4dannjjm 6404 27 of of IN cord-023095-4dannjjm 6404 28 intramammary intramammary JJ cord-023095-4dannjjm 6404 29 infection infection NN cord-023095-4dannjjm 6404 30 ( ( -LRB- cord-023095-4dannjjm 6404 31 IMI IMI NNP cord-023095-4dannjjm 6404 32 ) ) -RRB- cord-023095-4dannjjm 6404 33 . . . cord-023095-4dannjjm 6405 1 In in IN cord-023095-4dannjjm 6405 2 the the DT cord-023095-4dannjjm 6405 3 first first JJ cord-023095-4dannjjm 6405 4 study study NN cord-023095-4dannjjm 6405 5 , , , cord-023095-4dannjjm 6405 6 mammary mammary JJ cord-023095-4dannjjm 6405 7 quarter quarter NN cord-023095-4dannjjm 6405 8 foremilk foremilk NN cord-023095-4dannjjm 6405 9 samples sample NNS cord-023095-4dannjjm 6405 10 were be VBD cord-023095-4dannjjm 6405 11 aseptically aseptically RB cord-023095-4dannjjm 6405 12 collected collect VBN cord-023095-4dannjjm 6405 13 from from IN cord-023095-4dannjjm 6405 14 all all DT cord-023095-4dannjjm 6405 15 lactating lactate VBG cord-023095-4dannjjm 6405 16 cattle cattle NNS cord-023095-4dannjjm 6405 17 ( ( -LRB- cord-023095-4dannjjm 6405 18 $ $ $ cord-023095-4dannjjm 6405 19 180 180 CD cord-023095-4dannjjm 6405 20 head head NN cord-023095-4dannjjm 6405 21 ) ) -RRB- cord-023095-4dannjjm 6405 22 at at IN cord-023095-4dannjjm 6405 23 the the DT cord-023095-4dannjjm 6405 24 University University NNP cord-023095-4dannjjm 6405 25 of of IN cord-023095-4dannjjm 6405 26 Missouri Missouri NNP cord-023095-4dannjjm 6405 27 dairy dairy NN cord-023095-4dannjjm 6405 28 research research NN cord-023095-4dannjjm 6405 29 center center NN cord-023095-4dannjjm 6405 30 once once RB cord-023095-4dannjjm 6405 31 monthly monthly RB cord-023095-4dannjjm 6405 32 for for IN cord-023095-4dannjjm 6405 33 17 17 CD cord-023095-4dannjjm 6405 34 months month NNS cord-023095-4dannjjm 6405 35 for for IN cord-023095-4dannjjm 6405 36 bacterial bacterial JJ cord-023095-4dannjjm 6405 37 culture culture NN cord-023095-4dannjjm 6405 38 and and CC cord-023095-4dannjjm 6405 39 milk milk NN cord-023095-4dannjjm 6405 40 SCC SCC NNP cord-023095-4dannjjm 6405 41 . . . cord-023095-4dannjjm 6406 1 Staphylococcal staphylococcal JJ cord-023095-4dannjjm 6406 2 isolates isolate NNS cord-023095-4dannjjm 6406 3 were be VBD cord-023095-4dannjjm 6406 4 speciated speciate VBN cord-023095-4dannjjm 6406 5 by by IN cord-023095-4dannjjm 6406 6 sequencing sequence VBG cord-023095-4dannjjm 6406 7 the the DT cord-023095-4dannjjm 6406 8 rpoB rpoB -RRB- cord-023095-4dannjjm 6406 9 gene gene NN cord-023095-4dannjjm 6406 10 and and CC cord-023095-4dannjjm 6406 11 strain strain NN cord-023095-4dannjjm 6406 12 - - HYPH cord-023095-4dannjjm 6406 13 typed type VBN cord-023095-4dannjjm 6406 14 using use VBG cord-023095-4dannjjm 6406 15 pulsed pulse VBN cord-023095-4dannjjm 6406 16 - - HYPH cord-023095-4dannjjm 6406 17 field field NN cord-023095-4dannjjm 6406 18 gel gel NN cord-023095-4dannjjm 6406 19 electrophoresis electrophoresis NN cord-023095-4dannjjm 6406 20 ( ( -LRB- cord-023095-4dannjjm 6406 21 PFGE PFGE NNP cord-023095-4dannjjm 6406 22 ) ) -RRB- cord-023095-4dannjjm 6406 23 . . . cord-023095-4dannjjm 6407 1 Using use VBG cord-023095-4dannjjm 6407 2 species specie NNS cord-023095-4dannjjm 6407 3 and and CC cord-023095-4dannjjm 6407 4 fingerprint fingerprint NN cord-023095-4dannjjm 6407 5 data datum NNS cord-023095-4dannjjm 6407 6 along along IN cord-023095-4dannjjm 6407 7 with with IN cord-023095-4dannjjm 6407 8 published publish VBN cord-023095-4dannjjm 6407 9 definitions definition NNS cord-023095-4dannjjm 6407 10 for for IN cord-023095-4dannjjm 6407 11 staphylococcal staphylococcal JJ cord-023095-4dannjjm 6407 12 IMI IMI NNP cord-023095-4dannjjm 6407 13 , , , cord-023095-4dannjjm 6407 14 91 91 CD cord-023095-4dannjjm 6407 15 CNS CNS NNP cord-023095-4dannjjm 6407 16 IMIs imi NNS cord-023095-4dannjjm 6407 17 were be VBD cord-023095-4dannjjm 6407 18 identified identify VBN cord-023095-4dannjjm 6407 19 . . . cord-023095-4dannjjm 6408 1 Overall overall RB cord-023095-4dannjjm 6408 2 , , , cord-023095-4dannjjm 6408 3 11 11 CD cord-023095-4dannjjm 6408 4 species specie NNS cord-023095-4dannjjm 6408 5 of of IN cord-023095-4dannjjm 6408 6 CNS CNS NNP cord-023095-4dannjjm 6408 7 were be VBD cord-023095-4dannjjm 6408 8 identified identify VBN cord-023095-4dannjjm 6408 9 with with IN cord-023095-4dannjjm 6408 10 Staphylococcus Staphylococcus NNP cord-023095-4dannjjm 6408 11 chromogenes chromogene NNS cord-023095-4dannjjm 6408 12 , , , cord-023095-4dannjjm 6408 13 S. S. NNP cord-023095-4dannjjm 6408 14 cohnii cohnii NNP cord-023095-4dannjjm 6408 15 , , , cord-023095-4dannjjm 6408 16 S. S. NNP cord-023095-4dannjjm 6408 17 epidermidis epidermidis NN cord-023095-4dannjjm 6408 18 , , , cord-023095-4dannjjm 6408 19 and and CC cord-023095-4dannjjm 6408 20 S. S. NNP cord-023095-4dannjjm 6408 21 simulans simulan NNS cord-023095-4dannjjm 6408 22 being be VBG cord-023095-4dannjjm 6408 23 most most RBS cord-023095-4dannjjm 6408 24 prevalent prevalent JJ cord-023095-4dannjjm 6408 25 . . . cord-023095-4dannjjm 6409 1 Duration duration NN cord-023095-4dannjjm 6409 2 of of IN cord-023095-4dannjjm 6409 3 IMI IMI NNP cord-023095-4dannjjm 6409 4 and and CC cord-023095-4dannjjm 6409 5 SCC SCC NNP cord-023095-4dannjjm 6409 6 data datum NNS cord-023095-4dannjjm 6409 7 were be VBD cord-023095-4dannjjm 6409 8 analyzed analyze VBN cord-023095-4dannjjm 6409 9 using use VBG cord-023095-4dannjjm 6409 10 regression regression NN cord-023095-4dannjjm 6409 11 models model NNS cord-023095-4dannjjm 6409 12 accounting account VBG cord-023095-4dannjjm 6409 13 for for IN cord-023095-4dannjjm 6409 14 repeated repeat VBN cord-023095-4dannjjm 6409 15 measures measure NNS cord-023095-4dannjjm 6409 16 . . . cord-023095-4dannjjm 6410 1 Mean mean JJ cord-023095-4dannjjm 6410 2 milk milk NN cord-023095-4dannjjm 6410 3 SCC SCC NNP cord-023095-4dannjjm 6410 4 and and CC cord-023095-4dannjjm 6410 5 duration duration NN cord-023095-4dannjjm 6410 6 of of IN cord-023095-4dannjjm 6410 7 IMI IMI NNP cord-023095-4dannjjm 6410 8 were be VBD cord-023095-4dannjjm 6410 9 found find VBN cord-023095-4dannjjm 6410 10 to to TO cord-023095-4dannjjm 6410 11 differ differ VB cord-023095-4dannjjm 6410 12 between between IN cord-023095-4dannjjm 6410 13 CNS CNS NNP cord-023095-4dannjjm 6410 14 species specie NNS cord-023095-4dannjjm 6410 15 ( ( -LRB- cord-023095-4dannjjm 6410 16 P p NN cord-023095-4dannjjm 6410 17 o o NN cord-023095-4dannjjm 6410 18 0.05 0.05 CD cord-023095-4dannjjm 6410 19 ) ) -RRB- cord-023095-4dannjjm 6410 20 . . . cord-023095-4dannjjm 6411 1 Although although IN cord-023095-4dannjjm 6411 2 most most JJS cord-023095-4dannjjm 6411 3 IMIs imi NNS cord-023095-4dannjjm 6411 4 were be VBD cord-023095-4dannjjm 6411 5 of of IN cord-023095-4dannjjm 6411 6 short short JJ cord-023095-4dannjjm 6411 7 duration duration NN cord-023095-4dannjjm 6411 8 ( ( -LRB- cord-023095-4dannjjm 6411 9 1 1 CD cord-023095-4dannjjm 6411 10 month month NN cord-023095-4dannjjm 6411 11 ) ) -RRB- cord-023095-4dannjjm 6411 12 , , , cord-023095-4dannjjm 6411 13 Staphylococcus Staphylococcus NNP cord-023095-4dannjjm 6411 14 capitis capitis NN cord-023095-4dannjjm 6411 15 and and CC cord-023095-4dannjjm 6411 16 S. S. NNP cord-023095-4dannjjm 6411 17 chromogenes chromogene NNS cord-023095-4dannjjm 6411 18 IMIs imi NNS cord-023095-4dannjjm 6411 19 had have VBD cord-023095-4dannjjm 6411 20 longer long JJR cord-023095-4dannjjm 6411 21 mean mean VB cord-023095-4dannjjm 6411 22 durations duration NNS cord-023095-4dannjjm 6411 23 of of IN cord-023095-4dannjjm 6411 24 infection infection NN cord-023095-4dannjjm 6411 25 than than IN cord-023095-4dannjjm 6411 26 3 3 CD cord-023095-4dannjjm 6411 27 or or CC cord-023095-4dannjjm 6411 28 more more JJR cord-023095-4dannjjm 6411 29 of of IN cord-023095-4dannjjm 6411 30 the the DT cord-023095-4dannjjm 6411 31 other other JJ cord-023095-4dannjjm 6411 32 species specie NNS cord-023095-4dannjjm 6411 33 isolated isolate VBN cord-023095-4dannjjm 6411 34 . . . cord-023095-4dannjjm 6412 1 Mean mean JJ cord-023095-4dannjjm 6412 2 SCCs scc NNS cord-023095-4dannjjm 6412 3 were be VBD cord-023095-4dannjjm 6412 4 under under IN cord-023095-4dannjjm 6412 5 350,000 350,000 CD cord-023095-4dannjjm 6412 6 cells cell NNS cord-023095-4dannjjm 6412 7 / / SYM cord-023095-4dannjjm 6412 8 ml ml NNS cord-023095-4dannjjm 6412 9 in in IN cord-023095-4dannjjm 6412 10 most most JJS cord-023095-4dannjjm 6412 11 cases case NNS cord-023095-4dannjjm 6412 12 . . . cord-023095-4dannjjm 6413 1 However however RB cord-023095-4dannjjm 6413 2 , , , cord-023095-4dannjjm 6413 3 Staphylococcus Staphylococcus NNP cord-023095-4dannjjm 6413 4 simulans simulan NNS cord-023095-4dannjjm 6413 5 and and CC cord-023095-4dannjjm 6413 6 S. S. NNP cord-023095-4dannjjm 6413 7 xylosus xylosus NNP cord-023095-4dannjjm 6413 8 IMIs imi NNS cord-023095-4dannjjm 6413 9 were be VBD cord-023095-4dannjjm 6413 10 more more RBR cord-023095-4dannjjm 6413 11 inflammatory inflammatory JJ cord-023095-4dannjjm 6413 12 ( ( -LRB- cord-023095-4dannjjm 6413 13 mean mean VB cord-023095-4dannjjm 6413 14 4 4 CD cord-023095-4dannjjm 6413 15 600,000 600,000 CD cord-023095-4dannjjm 6413 16 cells cell NNS cord-023095-4dannjjm 6413 17 / / SYM cord-023095-4dannjjm 6413 18 ml ml NN cord-023095-4dannjjm 6413 19 ) ) -RRB- cord-023095-4dannjjm 6413 20 and and CC cord-023095-4dannjjm 6413 21 had have VBD cord-023095-4dannjjm 6413 22 a a DT cord-023095-4dannjjm 6413 23 higher high JJR cord-023095-4dannjjm 6413 24 mean mean JJ cord-023095-4dannjjm 6413 25 SCC SCC NNP cord-023095-4dannjjm 6413 26 than than IN cord-023095-4dannjjm 6413 27 S. S. NNP cord-023095-4dannjjm 6413 28 cohnii cohnii NNP cord-023095-4dannjjm 6413 29 , , , cord-023095-4dannjjm 6413 30 S. S. NNP cord-023095-4dannjjm 6413 31 epidermidis epidermidis NN cord-023095-4dannjjm 6413 32 , , , cord-023095-4dannjjm 6413 33 and and CC cord-023095-4dannjjm 6413 34 S. S. NNP cord-023095-4dannjjm 6413 35 haemolyticus haemolyticus NNP cord-023095-4dannjjm 6413 36 . . . cord-023095-4dannjjm 6414 1 To to TO cord-023095-4dannjjm 6414 2 examine examine VB cord-023095-4dannjjm 6414 3 the the DT cord-023095-4dannjjm 6414 4 relationship relationship NN cord-023095-4dannjjm 6414 5 between between IN cord-023095-4dannjjm 6414 6 CNS CNS NNP cord-023095-4dannjjm 6414 7 IMI IMI NNP cord-023095-4dannjjm 6414 8 and and CC cord-023095-4dannjjm 6414 9 milk milk NN cord-023095-4dannjjm 6414 10 SCC SCC NNP cord-023095-4dannjjm 6414 11 in in IN cord-023095-4dannjjm 6414 12 a a DT cord-023095-4dannjjm 6414 13 larger large JJR cord-023095-4dannjjm 6414 14 population population NN cord-023095-4dannjjm 6414 15 of of IN cord-023095-4dannjjm 6414 16 cattle cattle NNS cord-023095-4dannjjm 6414 17 , , , cord-023095-4dannjjm 6414 18 CNS CNS NNP cord-023095-4dannjjm 6414 19 isolates isolate NNS cord-023095-4dannjjm 6414 20 from from IN cord-023095-4dannjjm 6414 21 the the DT cord-023095-4dannjjm 6414 22 Canadian canadian JJ cord-023095-4dannjjm 6414 23 Bovine Bovine NNP cord-023095-4dannjjm 6414 24 Mastitis Mastitis NNP cord-023095-4dannjjm 6414 25 Research Research NNP cord-023095-4dannjjm 6414 26 Network Network NNP cord-023095-4dannjjm 6414 27 ( ( -LRB- cord-023095-4dannjjm 6414 28 CBMRN CBMRN NNP cord-023095-4dannjjm 6414 29 ) ) -RRB- cord-023095-4dannjjm 6414 30 culture culture NN cord-023095-4dannjjm 6414 31 collection collection NN cord-023095-4dannjjm 6414 32 were be VBD cord-023095-4dannjjm 6414 33 obtained obtain VBN cord-023095-4dannjjm 6414 34 for for IN cord-023095-4dannjjm 6414 35 speciation speciation NN cord-023095-4dannjjm 6414 36 . . . cord-023095-4dannjjm 6415 1 Speciation speciation NN cord-023095-4dannjjm 6415 2 and and CC cord-023095-4dannjjm 6415 3 fingerprinting fingerprinting NN cord-023095-4dannjjm 6415 4 were be VBD cord-023095-4dannjjm 6415 5 performed perform VBN cord-023095-4dannjjm 6415 6 as as IN cord-023095-4dannjjm 6415 7 above above RB cord-023095-4dannjjm 6415 8 . . . cord-023095-4dannjjm 6416 1 Isolates isolate NNS cord-023095-4dannjjm 6416 2 were be VBD cord-023095-4dannjjm 6416 3 from from IN cord-023095-4dannjjm 6416 4 subclinical subclinical JJ cord-023095-4dannjjm 6416 5 IMI IMI NNP cord-023095-4dannjjm 6416 6 from from IN cord-023095-4dannjjm 6416 7 before before RB cord-023095-4dannjjm 6416 8 and and CC cord-023095-4dannjjm 6416 9 after after IN cord-023095-4dannjjm 6416 10 the the DT cord-023095-4dannjjm 6416 11 dry dry JJ cord-023095-4dannjjm 6416 12 period period NN cord-023095-4dannjjm 6416 13 and and CC cord-023095-4dannjjm 6416 14 from from IN cord-023095-4dannjjm 6416 15 subclinical subclinical JJ cord-023095-4dannjjm 6416 16 IMI IMI NNP cord-023095-4dannjjm 6416 17 during during IN cord-023095-4dannjjm 6416 18 lactation lactation NN cord-023095-4dannjjm 6416 19 . . . cord-023095-4dannjjm 6417 1 Data datum NNS cord-023095-4dannjjm 6417 2 associated associate VBN cord-023095-4dannjjm 6417 3 with with IN cord-023095-4dannjjm 6417 4 each each DT cord-023095-4dannjjm 6417 5 isolate isolate NN cord-023095-4dannjjm 6417 6 were be VBD cord-023095-4dannjjm 6417 7 obtained obtain VBN cord-023095-4dannjjm 6417 8 from from IN cord-023095-4dannjjm 6417 9 the the DT cord-023095-4dannjjm 6417 10 CBMRN CBMRN NNP cord-023095-4dannjjm 6417 11 database database NN cord-023095-4dannjjm 6417 12 . . . cord-023095-4dannjjm 6418 1 Nine nine CD cord-023095-4dannjjm 6418 2 - - HYPH cord-023095-4dannjjm 6418 3 hundred hundred CD cord-023095-4dannjjm 6418 4 - - HYPH cord-023095-4dannjjm 6418 5 thirty thirty CD cord-023095-4dannjjm 6418 6 - - HYPH cord-023095-4dannjjm 6418 7 eight eight CD cord-023095-4dannjjm 6418 8 isolates isolate NNS cord-023095-4dannjjm 6418 9 from from IN cord-023095-4dannjjm 6418 10 696 696 CD cord-023095-4dannjjm 6418 11 mammary mammary JJ cord-023095-4dannjjm 6418 12 quarters quarter NNS cord-023095-4dannjjm 6418 13 in in IN cord-023095-4dannjjm 6418 14 89 89 CD cord-023095-4dannjjm 6418 15 herds herd NNS cord-023095-4dannjjm 6418 16 were be VBD cord-023095-4dannjjm 6418 17 successfully successfully RB cord-023095-4dannjjm 6418 18 speciated speciate VBN cord-023095-4dannjjm 6418 19 . . . cord-023095-4dannjjm 6419 1 Twenty twenty CD cord-023095-4dannjjm 6419 2 - - HYPH cord-023095-4dannjjm 6419 3 two two CD cord-023095-4dannjjm 6419 4 different different JJ cord-023095-4dannjjm 6419 5 species specie NNS cord-023095-4dannjjm 6419 6 of of IN cord-023095-4dannjjm 6419 7 CNS CNS NNP cord-023095-4dannjjm 6419 8 were be VBD cord-023095-4dannjjm 6419 9 identified identify VBN cord-023095-4dannjjm 6419 10 . . . cord-023095-4dannjjm 6420 1 Staphylococcus Staphylococcus NNP cord-023095-4dannjjm 6420 2 chromogenes chromogene NNS cord-023095-4dannjjm 6420 3 was be VBD cord-023095-4dannjjm 6420 4 the the DT cord-023095-4dannjjm 6420 5 most most RBS cord-023095-4dannjjm 6420 6 frequent frequent JJ cord-023095-4dannjjm 6420 7 species specie NNS cord-023095-4dannjjm 6420 8 identified identify VBD cord-023095-4dannjjm 6420 9 accounting account VBG cord-023095-4dannjjm 6420 10 for for IN cord-023095-4dannjjm 6420 11 40 40 CD cord-023095-4dannjjm 6420 12 % % NN cord-023095-4dannjjm 6420 13 of of IN cord-023095-4dannjjm 6420 14 the the DT cord-023095-4dannjjm 6420 15 infections infection NNS cord-023095-4dannjjm 6420 16 . . . cord-023095-4dannjjm 6421 1 Three three CD cord-023095-4dannjjm 6421 2 species specie NNS cord-023095-4dannjjm 6421 3 , , , cord-023095-4dannjjm 6421 4 S. S. NNP cord-023095-4dannjjm 6421 5 chromogenes chromogene NNS cord-023095-4dannjjm 6421 6 , , , cord-023095-4dannjjm 6421 7 S. S. NNP cord-023095-4dannjjm 6421 8 xylosus xylosus NNP cord-023095-4dannjjm 6421 9 , , , cord-023095-4dannjjm 6421 10 and and CC cord-023095-4dannjjm 6421 11 S. S. NNP cord-023095-4dannjjm 6421 12 simulans simulans NNP cord-023095-4dannjjm 6421 13 accounted account VBD cord-023095-4dannjjm 6421 14 for for IN cord-023095-4dannjjm 6421 15 475 475 CD cord-023095-4dannjjm 6421 16 % % NN cord-023095-4dannjjm 6421 17 of of IN cord-023095-4dannjjm 6421 18 all all DT cord-023095-4dannjjm 6421 19 infections infection NNS cord-023095-4dannjjm 6421 20 . . . cord-023095-4dannjjm 6422 1 Data datum NNS cord-023095-4dannjjm 6422 2 were be VBD cord-023095-4dannjjm 6422 3 analyzed analyze VBN cord-023095-4dannjjm 6422 4 using use VBG cord-023095-4dannjjm 6422 5 a a DT cord-023095-4dannjjm 6422 6 linear linear JJ cord-023095-4dannjjm 6422 7 hierarchical hierarchical JJ cord-023095-4dannjjm 6422 8 repeated repeat VBN cord-023095-4dannjjm 6422 9 measures measure NNS cord-023095-4dannjjm 6422 10 mixed mixed JJ cord-023095-4dannjjm 6422 11 model model NN cord-023095-4dannjjm 6422 12 . . . cord-023095-4dannjjm 6423 1 Differences difference NNS cord-023095-4dannjjm 6423 2 in in IN cord-023095-4dannjjm 6423 3 mean mean JJ cord-023095-4dannjjm 6423 4 SCC SCC NNP cord-023095-4dannjjm 6423 5 were be VBD cord-023095-4dannjjm 6423 6 found find VBN cord-023095-4dannjjm 6423 7 between between IN cord-023095-4dannjjm 6423 8 some some DT cord-023095-4dannjjm 6423 9 CNS CNS NNP cord-023095-4dannjjm 6423 10 species specie NNS cord-023095-4dannjjm 6423 11 and and CC cord-023095-4dannjjm 6423 12 culture culture NN cord-023095-4dannjjm 6423 13 negative negative JJ cord-023095-4dannjjm 6423 14 control control NN cord-023095-4dannjjm 6423 15 quarters quarter NNS cord-023095-4dannjjm 6423 16 and and CC cord-023095-4dannjjm 6423 17 also also RB cord-023095-4dannjjm 6423 18 between between IN cord-023095-4dannjjm 6423 19 different different JJ cord-023095-4dannjjm 6423 20 species specie NNS cord-023095-4dannjjm 6423 21 of of IN cord-023095-4dannjjm 6423 22 CNS CNS NNP cord-023095-4dannjjm 6423 23 ( ( -LRB- cord-023095-4dannjjm 6423 24 P p NN cord-023095-4dannjjm 6423 25 o o NN cord-023095-4dannjjm 6423 26 0.05 0.05 CD cord-023095-4dannjjm 6423 27 ) ) -RRB- cord-023095-4dannjjm 6423 28 . . . cord-023095-4dannjjm 6424 1 Overall overall RB cord-023095-4dannjjm 6424 2 , , , cord-023095-4dannjjm 6424 3 our -PRON- PRP$ cord-023095-4dannjjm 6424 4 data datum NNS cord-023095-4dannjjm 6424 5 demonstrate demonstrate VBP cord-023095-4dannjjm 6424 6 potential potential JJ cord-023095-4dannjjm 6424 7 differences difference NNS cord-023095-4dannjjm 6424 8 in in IN cord-023095-4dannjjm 6424 9 pathogenicity pathogenicity NN cord-023095-4dannjjm 6424 10 between between IN cord-023095-4dannjjm 6424 11 strains strain NNS cord-023095-4dannjjm 6424 12 of of IN cord-023095-4dannjjm 6424 13 CNS CNS NNP cord-023095-4dannjjm 6424 14 that that WDT cord-023095-4dannjjm 6424 15 cause cause VBP cord-023095-4dannjjm 6424 16 bovine bovine JJ cord-023095-4dannjjm 6424 17 mastitis mastitis NN cord-023095-4dannjjm 6424 18 . . . cord-023095-4dannjjm 6425 1 Passive passive JJ cord-023095-4dannjjm 6425 2 transfer transfer NN cord-023095-4dannjjm 6425 3 of of IN cord-023095-4dannjjm 6425 4 maternally maternally RB cord-023095-4dannjjm 6425 5 derived derive VBN cord-023095-4dannjjm 6425 6 antibodies antibody NNS cord-023095-4dannjjm 6425 7 via via IN cord-023095-4dannjjm 6425 8 ingestion ingestion NN cord-023095-4dannjjm 6425 9 of of IN cord-023095-4dannjjm 6425 10 good good JJ cord-023095-4dannjjm 6425 11 - - HYPH cord-023095-4dannjjm 6425 12 quality quality NN cord-023095-4dannjjm 6425 13 colostrum colostrum NN cord-023095-4dannjjm 6425 14 within within IN cord-023095-4dannjjm 6425 15 the the DT cord-023095-4dannjjm 6425 16 first first JJ cord-023095-4dannjjm 6425 17 24 24 CD cord-023095-4dannjjm 6425 18 hours hour NNS cord-023095-4dannjjm 6425 19 of of IN cord-023095-4dannjjm 6425 20 life life NN cord-023095-4dannjjm 6425 21 is be VBZ cord-023095-4dannjjm 6425 22 crucial crucial JJ cord-023095-4dannjjm 6425 23 for for IN cord-023095-4dannjjm 6425 24 the the DT cord-023095-4dannjjm 6425 25 health health NN cord-023095-4dannjjm 6425 26 and and CC cord-023095-4dannjjm 6425 27 future future JJ cord-023095-4dannjjm 6425 28 productivity productivity NN cord-023095-4dannjjm 6425 29 of of IN cord-023095-4dannjjm 6425 30 dairy dairy NN cord-023095-4dannjjm 6425 31 calves calf NNS cord-023095-4dannjjm 6425 32 . . . cord-023095-4dannjjm 6426 1 However however RB cord-023095-4dannjjm 6426 2 , , , cord-023095-4dannjjm 6426 3 infectious infectious JJ cord-023095-4dannjjm 6426 4 diseases disease NNS cord-023095-4dannjjm 6426 5 can can MD cord-023095-4dannjjm 6426 6 be be VB cord-023095-4dannjjm 6426 7 transmitted transmit VBN cord-023095-4dannjjm 6426 8 via via IN cord-023095-4dannjjm 6426 9 colostrum colostrum NN cord-023095-4dannjjm 6426 10 feeding feeding NN cord-023095-4dannjjm 6426 11 , , , cord-023095-4dannjjm 6426 12 which which WDT cord-023095-4dannjjm 6426 13 may may MD cord-023095-4dannjjm 6426 14 require require VB cord-023095-4dannjjm 6426 15 use use NN cord-023095-4dannjjm 6426 16 of of IN cord-023095-4dannjjm 6426 17 a a DT cord-023095-4dannjjm 6426 18 colostrum colostrum NN cord-023095-4dannjjm 6426 19 replacement replacement NN cord-023095-4dannjjm 6426 20 product product NN cord-023095-4dannjjm 6426 21 or or CC cord-023095-4dannjjm 6426 22 pasteurization pasteurization NN cord-023095-4dannjjm 6426 23 to to TO cord-023095-4dannjjm 6426 24 decrease decrease VB cord-023095-4dannjjm 6426 25 disease disease NN cord-023095-4dannjjm 6426 26 transmission transmission NN cord-023095-4dannjjm 6426 27 . . . cord-023095-4dannjjm 6427 1 While while IN cord-023095-4dannjjm 6427 2 pasteurization pasteurization NN cord-023095-4dannjjm 6427 3 of of IN cord-023095-4dannjjm 6427 4 colostrum colostrum NN cord-023095-4dannjjm 6427 5 is be VBZ cord-023095-4dannjjm 6427 6 effective effective JJ cord-023095-4dannjjm 6427 7 for for IN cord-023095-4dannjjm 6427 8 sterilization sterilization NN cord-023095-4dannjjm 6427 9 , , , cord-023095-4dannjjm 6427 10 heating heating NN cord-023095-4dannjjm 6427 11 during during IN cord-023095-4dannjjm 6427 12 pasteurization pasteurization NN cord-023095-4dannjjm 6427 13 can can MD cord-023095-4dannjjm 6427 14 alter alter VB cord-023095-4dannjjm 6427 15 the the DT cord-023095-4dannjjm 6427 16 viscosity viscosity NN cord-023095-4dannjjm 6427 17 of of IN cord-023095-4dannjjm 6427 18 colostrum colostrum NN cord-023095-4dannjjm 6427 19 , , , cord-023095-4dannjjm 6427 20 destroys destroy VBZ cord-023095-4dannjjm 6427 21 important important JJ cord-023095-4dannjjm 6427 22 nutritional nutritional JJ cord-023095-4dannjjm 6427 23 biomolecules biomolecule NNS cord-023095-4dannjjm 6427 24 , , , cord-023095-4dannjjm 6427 25 and and CC cord-023095-4dannjjm 6427 26 has have VBZ cord-023095-4dannjjm 6427 27 been be VBN cord-023095-4dannjjm 6427 28 shown show VBN cord-023095-4dannjjm 6427 29 to to TO cord-023095-4dannjjm 6427 30 decrease decrease VB cord-023095-4dannjjm 6427 31 colostral colostral NNP cord-023095-4dannjjm 6427 32 IgG igg NN cord-023095-4dannjjm 6427 33 concentrations concentration NNS cord-023095-4dannjjm 6427 34 . . . cord-023095-4dannjjm 6428 1 The the DT cord-023095-4dannjjm 6428 2 purpose purpose NN cord-023095-4dannjjm 6428 3 of of IN cord-023095-4dannjjm 6428 4 this this DT cord-023095-4dannjjm 6428 5 study study NN cord-023095-4dannjjm 6428 6 was be VBD cord-023095-4dannjjm 6428 7 to to TO cord-023095-4dannjjm 6428 8 investigate investigate VB cord-023095-4dannjjm 6428 9 the the DT cord-023095-4dannjjm 6428 10 effect effect NN cord-023095-4dannjjm 6428 11 of of IN cord-023095-4dannjjm 6428 12 high high JJ cord-023095-4dannjjm 6428 13 pressure pressure NN cord-023095-4dannjjm 6428 14 processing processing NN cord-023095-4dannjjm 6428 15 ( ( -LRB- cord-023095-4dannjjm 6428 16 HPP hpp NN cord-023095-4dannjjm 6428 17 ) ) -RRB- cord-023095-4dannjjm 6428 18 on on IN cord-023095-4dannjjm 6428 19 the the DT cord-023095-4dannjjm 6428 20 viscosity viscosity NN cord-023095-4dannjjm 6428 21 , , , cord-023095-4dannjjm 6428 22 IgG igg NN cord-023095-4dannjjm 6428 23 concentration concentration NN cord-023095-4dannjjm 6428 24 , , , cord-023095-4dannjjm 6428 25 and and CC cord-023095-4dannjjm 6428 26 bacterial bacterial JJ cord-023095-4dannjjm 6428 27 contamination contamination NN cord-023095-4dannjjm 6428 28 of of IN cord-023095-4dannjjm 6428 29 bovine bovine JJ cord-023095-4dannjjm 6428 30 colostrum colostrum NN cord-023095-4dannjjm 6428 31 . . . cord-023095-4dannjjm 6429 1 First first JJ cord-023095-4dannjjm 6429 2 milking milk VBG cord-023095-4dannjjm 6429 3 colostrum colostrum NN cord-023095-4dannjjm 6429 4 samples sample NNS cord-023095-4dannjjm 6429 5 were be VBD cord-023095-4dannjjm 6429 6 collected collect VBN cord-023095-4dannjjm 6429 7 from from IN cord-023095-4dannjjm 6429 8 18 18 CD cord-023095-4dannjjm 6429 9 cows cow NNS cord-023095-4dannjjm 6429 10 from from IN cord-023095-4dannjjm 6429 11 3 3 CD cord-023095-4dannjjm 6429 12 different different JJ cord-023095-4dannjjm 6429 13 farms farm NNS cord-023095-4dannjjm 6429 14 , , , cord-023095-4dannjjm 6429 15 and and CC cord-023095-4dannjjm 6429 16 50 50 CD cord-023095-4dannjjm 6429 17 ml ml NNS cord-023095-4dannjjm 6429 18 aliquots aliquot NNS cord-023095-4dannjjm 6429 19 of of IN cord-023095-4dannjjm 6429 20 each each DT cord-023095-4dannjjm 6429 21 sample sample NN cord-023095-4dannjjm 6429 22 were be VBD cord-023095-4dannjjm 6429 23 pooled pool VBN cord-023095-4dannjjm 6429 24 for for IN cord-023095-4dannjjm 6429 25 analysis analysis NN cord-023095-4dannjjm 6429 26 . . . cord-023095-4dannjjm 6430 1 Pooled pool VBN cord-023095-4dannjjm 6430 2 colostrum colostrum NN cord-023095-4dannjjm 6430 3 was be VBD cord-023095-4dannjjm 6430 4 processed process VBN cord-023095-4dannjjm 6430 5 in in IN cord-023095-4dannjjm 6430 6 triplicate triplicate NN cord-023095-4dannjjm 6430 7 using use VBG cord-023095-4dannjjm 6430 8 an an DT cord-023095-4dannjjm 6430 9 isostatic isostatic JJ cord-023095-4dannjjm 6430 10 press press NN cord-023095-4dannjjm 6430 11 at at IN cord-023095-4dannjjm 6430 12 400 400 CD cord-023095-4dannjjm 6430 13 MPa MPa NNS cord-023095-4dannjjm 6430 14 ( ( -LRB- cord-023095-4dannjjm 6430 15 60,000 60,000 CD cord-023095-4dannjjm 6430 16 psig psig NNS cord-023095-4dannjjm 6430 17 ) ) -RRB- cord-023095-4dannjjm 6430 18 for for IN cord-023095-4dannjjm 6430 19 0 0 CD cord-023095-4dannjjm 6430 20 , , , cord-023095-4dannjjm 6430 21 5 5 CD cord-023095-4dannjjm 6430 22 , , , cord-023095-4dannjjm 6430 23 15 15 CD cord-023095-4dannjjm 6430 24 , , , cord-023095-4dannjjm 6430 25 30 30 CD cord-023095-4dannjjm 6430 26 , , , cord-023095-4dannjjm 6430 27 and and CC cord-023095-4dannjjm 6430 28 45 45 CD cord-023095-4dannjjm 6430 29 minutes minute NNS cord-023095-4dannjjm 6430 30 . . . cord-023095-4dannjjm 6431 1 Samples sample NNS cord-023095-4dannjjm 6431 2 were be VBD cord-023095-4dannjjm 6431 3 tested test VBN cord-023095-4dannjjm 6431 4 for for IN cord-023095-4dannjjm 6431 5 the the DT cord-023095-4dannjjm 6431 6 effects effect NNS cord-023095-4dannjjm 6431 7 of of IN cord-023095-4dannjjm 6431 8 HPP hpp NN cord-023095-4dannjjm 6431 9 on on IN cord-023095-4dannjjm 6431 10 the the DT cord-023095-4dannjjm 6431 11 viscosity viscosity NN cord-023095-4dannjjm 6431 12 , , , cord-023095-4dannjjm 6431 13 bacterial bacterial JJ cord-023095-4dannjjm 6431 14 load load NN cord-023095-4dannjjm 6431 15 ( ( -LRB- cord-023095-4dannjjm 6431 16 CFU CFU NNP cord-023095-4dannjjm 6431 17 / / SYM cord-023095-4dannjjm 6431 18 ml ml NNP cord-023095-4dannjjm 6431 19 ) ) -RRB- cord-023095-4dannjjm 6431 20 , , , cord-023095-4dannjjm 6431 21 and and CC cord-023095-4dannjjm 6431 22 IgG igg NN cord-023095-4dannjjm 6431 23 concentration concentration NN cord-023095-4dannjjm 6431 24 . . . cord-023095-4dannjjm 6432 1 There there EX cord-023095-4dannjjm 6432 2 was be VBD cord-023095-4dannjjm 6432 3 a a DT cord-023095-4dannjjm 6432 4 significant significant JJ cord-023095-4dannjjm 6432 5 decrease decrease NN cord-023095-4dannjjm 6432 6 ( ( -LRB- cord-023095-4dannjjm 6432 7 p p NN cord-023095-4dannjjm 6432 8 o o NN cord-023095-4dannjjm 6432 9 0.05 0.05 CD cord-023095-4dannjjm 6432 10 ) ) -RRB- cord-023095-4dannjjm 6432 11 in in IN cord-023095-4dannjjm 6432 12 bacterial bacterial JJ cord-023095-4dannjjm 6432 13 load load NN cord-023095-4dannjjm 6432 14 at at IN cord-023095-4dannjjm 6432 15 each each DT cord-023095-4dannjjm 6432 16 time time NN cord-023095-4dannjjm 6432 17 point point NN cord-023095-4dannjjm 6432 18 when when WRB cord-023095-4dannjjm 6432 19 compared compare VBN cord-023095-4dannjjm 6432 20 to to IN cord-023095-4dannjjm 6432 21 time time NN cord-023095-4dannjjm 6432 22 0 0 CD cord-023095-4dannjjm 6432 23 . . . cord-023095-4dannjjm 6433 1 No no DT cord-023095-4dannjjm 6433 2 significant significant JJ cord-023095-4dannjjm 6433 3 difference difference NN cord-023095-4dannjjm 6433 4 in in IN cord-023095-4dannjjm 6433 5 IgG igg NN cord-023095-4dannjjm 6433 6 concentration concentration NN cord-023095-4dannjjm 6433 7 was be VBD cord-023095-4dannjjm 6433 8 found find VBN cord-023095-4dannjjm 6433 9 between between IN cord-023095-4dannjjm 6433 10 any any DT cord-023095-4dannjjm 6433 11 time time NN cord-023095-4dannjjm 6433 12 points point NNS cord-023095-4dannjjm 6433 13 . . . cord-023095-4dannjjm 6434 1 Subjectively subjectively RB cord-023095-4dannjjm 6434 2 , , , cord-023095-4dannjjm 6434 3 the the DT cord-023095-4dannjjm 6434 4 colostrum colostrum NN cord-023095-4dannjjm 6434 5 viscosity viscosity NN cord-023095-4dannjjm 6434 6 appeared appear VBD cord-023095-4dannjjm 6434 7 to to TO cord-023095-4dannjjm 6434 8 increase increase VB cord-023095-4dannjjm 6434 9 with with IN cord-023095-4dannjjm 6434 10 the the DT cord-023095-4dannjjm 6434 11 processing processing NN cord-023095-4dannjjm 6434 12 time time NN cord-023095-4dannjjm 6434 13 , , , cord-023095-4dannjjm 6434 14 though though IN cord-023095-4dannjjm 6434 15 the the DT cord-023095-4dannjjm 6434 16 rheologic rheologic JJ cord-023095-4dannjjm 6434 17 assessment assessment NN cord-023095-4dannjjm 6434 18 has have VBZ cord-023095-4dannjjm 6434 19 not not RB cord-023095-4dannjjm 6434 20 been be VBN cord-023095-4dannjjm 6434 21 completed complete VBN cord-023095-4dannjjm 6434 22 at at IN cord-023095-4dannjjm 6434 23 this this DT cord-023095-4dannjjm 6434 24 time time NN cord-023095-4dannjjm 6434 25 . . . cord-023095-4dannjjm 6435 1 HPP HPP NNP cord-023095-4dannjjm 6435 2 appears appear VBZ cord-023095-4dannjjm 6435 3 to to TO cord-023095-4dannjjm 6435 4 be be VB cord-023095-4dannjjm 6435 5 an an DT cord-023095-4dannjjm 6435 6 effective effective JJ cord-023095-4dannjjm 6435 7 method method NN cord-023095-4dannjjm 6435 8 to to TO cord-023095-4dannjjm 6435 9 decrease decrease VB cord-023095-4dannjjm 6435 10 bacterial bacterial JJ cord-023095-4dannjjm 6435 11 contamination contamination NN cord-023095-4dannjjm 6435 12 of of IN cord-023095-4dannjjm 6435 13 colostrum colostrum NN cord-023095-4dannjjm 6435 14 while while IN cord-023095-4dannjjm 6435 15 maintaining maintain VBG cord-023095-4dannjjm 6435 16 appropriate appropriate JJ cord-023095-4dannjjm 6435 17 IgG igg NN cord-023095-4dannjjm 6435 18 concentrations concentration NNS cord-023095-4dannjjm 6435 19 . . . cord-023095-4dannjjm 6436 1 Minimizing minimize VBG cord-023095-4dannjjm 6436 2 the the DT cord-023095-4dannjjm 6436 3 processing processing NN cord-023095-4dannjjm 6436 4 time time NN cord-023095-4dannjjm 6436 5 or or CC cord-023095-4dannjjm 6436 6 pressure pressure NN cord-023095-4dannjjm 6436 7 may may MD cord-023095-4dannjjm 6436 8 be be VB cord-023095-4dannjjm 6436 9 necessary necessary JJ cord-023095-4dannjjm 6436 10 to to TO cord-023095-4dannjjm 6436 11 maintain maintain VB cord-023095-4dannjjm 6436 12 an an DT cord-023095-4dannjjm 6436 13 acceptable acceptable JJ cord-023095-4dannjjm 6436 14 viscosity viscosity NN cord-023095-4dannjjm 6436 15 of of IN cord-023095-4dannjjm 6436 16 the the DT cord-023095-4dannjjm 6436 17 colostrum colostrum NN cord-023095-4dannjjm 6436 18 . . . cord-023095-4dannjjm 6437 1 Based base VBN cord-023095-4dannjjm 6437 2 on on IN cord-023095-4dannjjm 6437 3 these these DT cord-023095-4dannjjm 6437 4 results result NNS cord-023095-4dannjjm 6437 5 , , , cord-023095-4dannjjm 6437 6 additional additional JJ cord-023095-4dannjjm 6437 7 studies study NNS cord-023095-4dannjjm 6437 8 are be VBP cord-023095-4dannjjm 6437 9 justified justify VBN cord-023095-4dannjjm 6437 10 in in IN cord-023095-4dannjjm 6437 11 order order NN cord-023095-4dannjjm 6437 12 to to TO cord-023095-4dannjjm 6437 13 determine determine VB cord-023095-4dannjjm 6437 14 the the DT cord-023095-4dannjjm 6437 15 optimum optimum JJ cord-023095-4dannjjm 6437 16 combination combination NN cord-023095-4dannjjm 6437 17 of of IN cord-023095-4dannjjm 6437 18 processing processing NN cord-023095-4dannjjm 6437 19 time time NN cord-023095-4dannjjm 6437 20 and and CC cord-023095-4dannjjm 6437 21 pressure pressure NN cord-023095-4dannjjm 6437 22 and and CC cord-023095-4dannjjm 6437 23 the the DT cord-023095-4dannjjm 6437 24 effect effect NN cord-023095-4dannjjm 6437 25 of of IN cord-023095-4dannjjm 6437 26 HPP hpp NN cord-023095-4dannjjm 6437 27 on on IN cord-023095-4dannjjm 6437 28 specific specific JJ cord-023095-4dannjjm 6437 29 bovine bovine JJ cord-023095-4dannjjm 6437 30 pathogens pathogen NNS cord-023095-4dannjjm 6437 31 . . . cord-023095-4dannjjm 6438 1 The the DT cord-023095-4dannjjm 6438 2 heme heme NN cord-023095-4dannjjm 6438 3 - - HYPH cord-023095-4dannjjm 6438 4 associated associate VBN cord-023095-4dannjjm 6438 5 iron iron NN cord-023095-4dannjjm 6438 6 - - HYPH cord-023095-4dannjjm 6438 7 binding bind VBG cord-023095-4dannjjm 6438 8 apoprotein apoprotein NNP cord-023095-4dannjjm 6438 9 lactoferrin lactoferrin NNP cord-023095-4dannjjm 6438 10 ( ( -LRB- cord-023095-4dannjjm 6438 11 LF LF NNP cord-023095-4dannjjm 6438 12 ) ) -RRB- cord-023095-4dannjjm 6438 13 is be VBZ cord-023095-4dannjjm 6438 14 known know VBN cord-023095-4dannjjm 6438 15 for for IN cord-023095-4dannjjm 6438 16 its -PRON- PRP$ cord-023095-4dannjjm 6438 17 , , , cord-023095-4dannjjm 6438 18 anti anti JJ cord-023095-4dannjjm 6438 19 - - JJ cord-023095-4dannjjm 6438 20 inflammatory inflammatory JJ cord-023095-4dannjjm 6438 21 , , , cord-023095-4dannjjm 6438 22 anti anti JJ cord-023095-4dannjjm 6438 23 - - JJ cord-023095-4dannjjm 6438 24 parasitic parasitic JJ cord-023095-4dannjjm 6438 25 , , , cord-023095-4dannjjm 6438 26 antimicrobial antimicrobial JJ cord-023095-4dannjjm 6438 27 and and CC cord-023095-4dannjjm 6438 28 bactericidal bactericidal JJ cord-023095-4dannjjm 6438 29 effects effect NNS cord-023095-4dannjjm 6438 30 . . . cord-023095-4dannjjm 6439 1 Lactoferrin Lactoferrin NNP cord-023095-4dannjjm 6439 2 demonstrates demonstrate VBZ cord-023095-4dannjjm 6439 3 ubiquity ubiquity NN cord-023095-4dannjjm 6439 4 throughout throughout IN cord-023095-4dannjjm 6439 5 mammalian mammalian JJ cord-023095-4dannjjm 6439 6 host host NN cord-023095-4dannjjm 6439 7 biological biological JJ cord-023095-4dannjjm 6439 8 fluids fluid NNS cord-023095-4dannjjm 6439 9 : : : cord-023095-4dannjjm 6439 10 Saliva saliva NN cord-023095-4dannjjm 6439 11 ; ; : cord-023095-4dannjjm 6439 12 tears tear NNS cord-023095-4dannjjm 6439 13 ; ; : cord-023095-4dannjjm 6439 14 mammary mammary JJ cord-023095-4dannjjm 6439 15 secretions secretion NNS cord-023095-4dannjjm 6439 16 , , , cord-023095-4dannjjm 6439 17 as as RB cord-023095-4dannjjm 6439 18 well well RB cord-023095-4dannjjm 6439 19 as as IN cord-023095-4dannjjm 6439 20 at at IN cord-023095-4dannjjm 6439 21 mucosal mucosal JJ cord-023095-4dannjjm 6439 22 surfaces surface NNS cord-023095-4dannjjm 6439 23 . . . cord-023095-4dannjjm 6440 1 It -PRON- PRP cord-023095-4dannjjm 6440 2 is be VBZ cord-023095-4dannjjm 6440 3 also also RB cord-023095-4dannjjm 6440 4 released release VBN cord-023095-4dannjjm 6440 5 from from IN cord-023095-4dannjjm 6440 6 immune immune JJ cord-023095-4dannjjm 6440 7 cells cell NNS cord-023095-4dannjjm 6440 8 under under IN cord-023095-4dannjjm 6440 9 pathogenic pathogenic JJ cord-023095-4dannjjm 6440 10 stimulation stimulation NN cord-023095-4dannjjm 6440 11 . . . cord-023095-4dannjjm 6441 1 The the DT cord-023095-4dannjjm 6441 2 purpose purpose NN cord-023095-4dannjjm 6441 3 of of IN cord-023095-4dannjjm 6441 4 this this DT cord-023095-4dannjjm 6441 5 study study NN cord-023095-4dannjjm 6441 6 which which WDT cord-023095-4dannjjm 6441 7 has have VBZ cord-023095-4dannjjm 6441 8 been be VBN cord-023095-4dannjjm 6441 9 approved approve VBN cord-023095-4dannjjm 6441 10 by by IN cord-023095-4dannjjm 6441 11 Western Western NNP cord-023095-4dannjjm 6441 12 University University NNP cord-023095-4dannjjm 6441 13 's 's POS cord-023095-4dannjjm 6441 14 Institutional Institutional NNP cord-023095-4dannjjm 6441 15 Animal Animal NNP cord-023095-4dannjjm 6441 16 Care Care NNP cord-023095-4dannjjm 6441 17 and and CC cord-023095-4dannjjm 6441 18 Use Use NNP cord-023095-4dannjjm 6441 19 Committee Committee NNP cord-023095-4dannjjm 6441 20 is be VBZ cord-023095-4dannjjm 6441 21 to to TO cord-023095-4dannjjm 6441 22 further further RB cord-023095-4dannjjm 6441 23 characterize characterize VB cord-023095-4dannjjm 6441 24 the the DT cord-023095-4dannjjm 6441 25 mechanisms mechanism NNS cord-023095-4dannjjm 6441 26 through through IN cord-023095-4dannjjm 6441 27 which which WDT cord-023095-4dannjjm 6441 28 LF LF NNP cord-023095-4dannjjm 6441 29 modulates modulate VBZ cord-023095-4dannjjm 6441 30 inflammation inflammation NN cord-023095-4dannjjm 6441 31 in in IN cord-023095-4dannjjm 6441 32 the the DT cord-023095-4dannjjm 6441 33 face face NN cord-023095-4dannjjm 6441 34 of of IN cord-023095-4dannjjm 6441 35 bacterial bacterial JJ cord-023095-4dannjjm 6441 36 endotoxin endotoxin NN cord-023095-4dannjjm 6441 37 . . . cord-023095-4dannjjm 6442 1 It -PRON- PRP cord-023095-4dannjjm 6442 2 was be VBD cord-023095-4dannjjm 6442 3 hypothesized hypothesize VBN cord-023095-4dannjjm 6442 4 that that IN cord-023095-4dannjjm 6442 5 LF LF NNP cord-023095-4dannjjm 6442 6 would would MD cord-023095-4dannjjm 6442 7 inhibit inhibit VB cord-023095-4dannjjm 6442 8 p38 p38 JJ cord-023095-4dannjjm 6442 9 phosphorylation phosphorylation NN cord-023095-4dannjjm 6442 10 . . . cord-023095-4dannjjm 6443 1 Numerous numerous JJ cord-023095-4dannjjm 6443 2 studies study NNS cord-023095-4dannjjm 6443 3 speak speak VBP cord-023095-4dannjjm 6443 4 to to IN cord-023095-4dannjjm 6443 5 the the DT cord-023095-4dannjjm 6443 6 ability ability NN cord-023095-4dannjjm 6443 7 of of IN cord-023095-4dannjjm 6443 8 LF lf NN cord-023095-4dannjjm 6443 9 to to TO cord-023095-4dannjjm 6443 10 alter alter VB cord-023095-4dannjjm 6443 11 leukocyte leukocyte NN cord-023095-4dannjjm 6443 12 function function NN cord-023095-4dannjjm 6443 13 , , , cord-023095-4dannjjm 6443 14 inhibit inhibit VB cord-023095-4dannjjm 6443 15 cytokine cytokine JJ cord-023095-4dannjjm 6443 16 production production NN cord-023095-4dannjjm 6443 17 , , , cord-023095-4dannjjm 6443 18 and and CC cord-023095-4dannjjm 6443 19 bind bind VB cord-023095-4dannjjm 6443 20 lipopolysaccharide lipopolysaccharide NN cord-023095-4dannjjm 6443 21 ( ( -LRB- cord-023095-4dannjjm 6443 22 LPS LPS NNP cord-023095-4dannjjm 6443 23 ) ) -RRB- cord-023095-4dannjjm 6443 24 ; ; : cord-023095-4dannjjm 6443 25 mechanisms mechanism NNS cord-023095-4dannjjm 6443 26 through through IN cord-023095-4dannjjm 6443 27 which which WDT cord-023095-4dannjjm 6443 28 it -PRON- PRP cord-023095-4dannjjm 6443 29 is be VBZ cord-023095-4dannjjm 6443 30 believed believe VBN cord-023095-4dannjjm 6443 31 to to TO cord-023095-4dannjjm 6443 32 achieve achieve VB cord-023095-4dannjjm 6443 33 its -PRON- PRP$ cord-023095-4dannjjm 6443 34 anti anti JJ cord-023095-4dannjjm 6443 35 - - JJ cord-023095-4dannjjm 6443 36 inflammatory inflammatory JJ cord-023095-4dannjjm 6443 37 effects effect NNS cord-023095-4dannjjm 6443 38 . . . cord-023095-4dannjjm 6444 1 Recently recently RB cord-023095-4dannjjm 6444 2 , , , cord-023095-4dannjjm 6444 3 investigators investigator NNS cord-023095-4dannjjm 6444 4 demonstrated demonstrate VBD cord-023095-4dannjjm 6444 5 its -PRON- PRP$ cord-023095-4dannjjm 6444 6 ability ability NN cord-023095-4dannjjm 6444 7 to to TO cord-023095-4dannjjm 6444 8 interact interact VB cord-023095-4dannjjm 6444 9 with with IN cord-023095-4dannjjm 6444 10 host host NN cord-023095-4dannjjm 6444 11 DNA dna NN cord-023095-4dannjjm 6444 12 while while IN cord-023095-4dannjjm 6444 13 others other NNS cord-023095-4dannjjm 6444 14 describe describe VBP cord-023095-4dannjjm 6444 15 regulation regulation NN cord-023095-4dannjjm 6444 16 of of IN cord-023095-4dannjjm 6444 17 granulocyte granulocyte NN cord-023095-4dannjjm 6444 18 adhesion adhesion NN cord-023095-4dannjjm 6444 19 and and CC cord-023095-4dannjjm 6444 20 motility motility NN cord-023095-4dannjjm 6444 21 ; ; : cord-023095-4dannjjm 6444 22 elucidating elucidate VBG cord-023095-4dannjjm 6444 23 its -PRON- PRP$ cord-023095-4dannjjm 6444 24 roles role NNS cord-023095-4dannjjm 6444 25 in in IN cord-023095-4dannjjm 6444 26 the the DT cord-023095-4dannjjm 6444 27 apoptotic apoptotic JJ cord-023095-4dannjjm 6444 28 signaling signaling NN cord-023095-4dannjjm 6444 29 . . . cord-023095-4dannjjm 6445 1 In in IN cord-023095-4dannjjm 6445 2 earlier early JJR cord-023095-4dannjjm 6445 3 studies study NNS cord-023095-4dannjjm 6445 4 , , , cord-023095-4dannjjm 6445 5 Dawes Dawes NNP cord-023095-4dannjjm 6445 6 ME ME NNP cord-023095-4dannjjm 6445 7 , , , cord-023095-4dannjjm 6445 8 et et NNP cord-023095-4dannjjm 6445 9 al al NNP cord-023095-4dannjjm 6445 10 . . NNP cord-023095-4dannjjm 6445 11 demonstrated demonstrate VBD cord-023095-4dannjjm 6445 12 lactoferrin lactoferrin NNP cord-023095-4dannjjm 6445 13 's 's POS cord-023095-4dannjjm 6445 14 ability ability NN cord-023095-4dannjjm 6445 15 to to TO cord-023095-4dannjjm 6445 16 limit limit VB cord-023095-4dannjjm 6445 17 the the DT cord-023095-4dannjjm 6445 18 expression expression NN cord-023095-4dannjjm 6445 19 of of IN cord-023095-4dannjjm 6445 20 inducible inducible JJ cord-023095-4dannjjm 6445 21 cyclooxygenase-2 cyclooxygenase-2 NNP cord-023095-4dannjjm 6445 22 and and CC cord-023095-4dannjjm 6445 23 the the DT cord-023095-4dannjjm 6445 24 gelatinase gelatinase NN cord-023095-4dannjjm 6445 25 , , , cord-023095-4dannjjm 6445 26 matrix matrix NN cord-023095-4dannjjm 6445 27 metalloproteinase metalloproteinase NN cord-023095-4dannjjm 6445 28 -9 -9 NN cord-023095-4dannjjm 6445 29 by by IN cord-023095-4dannjjm 6445 30 LPS LPS NNP cord-023095-4dannjjm 6445 31 - - HYPH cord-023095-4dannjjm 6445 32 induced induce VBN cord-023095-4dannjjm 6445 33 macrophages macrophage NNS cord-023095-4dannjjm 6445 34 . . . cord-023095-4dannjjm 6446 1 The the DT cord-023095-4dannjjm 6446 2 generation generation NN cord-023095-4dannjjm 6446 3 of of IN cord-023095-4dannjjm 6446 4 these these DT cord-023095-4dannjjm 6446 5 inflammatory inflammatory JJ cord-023095-4dannjjm 6446 6 mediators mediator NNS cord-023095-4dannjjm 6446 7 is be VBZ cord-023095-4dannjjm 6446 8 modulated modulate VBN cord-023095-4dannjjm 6446 9 by by IN cord-023095-4dannjjm 6446 10 pro pro JJ cord-023095-4dannjjm 6446 11 - - JJ cord-023095-4dannjjm 6446 12 inflammatory inflammatory JJ cord-023095-4dannjjm 6446 13 cytokines cytokine NNS cord-023095-4dannjjm 6446 14 such such JJ cord-023095-4dannjjm 6446 15 as as IN cord-023095-4dannjjm 6446 16 interleukin-1 interleukin-1 NNP cord-023095-4dannjjm 6446 17 b b . cord-023095-4dannjjm 6446 18 ( ( -LRB- cord-023095-4dannjjm 6446 19 IL-1 IL-1 NNP cord-023095-4dannjjm 6446 20 b b NNP cord-023095-4dannjjm 6446 21 ) ) -RRB- cord-023095-4dannjjm 6446 22 and and CC cord-023095-4dannjjm 6446 23 tumor tumor NN cord-023095-4dannjjm 6446 24 necrosis necrosis NN cord-023095-4dannjjm 6446 25 factor factor NN cord-023095-4dannjjm 6446 26 - - HYPH cord-023095-4dannjjm 6446 27 alpha alpha NN cord-023095-4dannjjm 6446 28 ( ( -LRB- cord-023095-4dannjjm 6446 29 TNF TNF NNP cord-023095-4dannjjm 6446 30 - - HYPH cord-023095-4dannjjm 6446 31 a a NNP cord-023095-4dannjjm 6446 32 ) ) -RRB- cord-023095-4dannjjm 6446 33 , , , cord-023095-4dannjjm 6446 34 the the DT cord-023095-4dannjjm 6446 35 production production NN cord-023095-4dannjjm 6446 36 of of IN cord-023095-4dannjjm 6446 37 both both DT cord-023095-4dannjjm 6446 38 being be VBG cord-023095-4dannjjm 6446 39 dependent dependent JJ cord-023095-4dannjjm 6446 40 on on IN cord-023095-4dannjjm 6446 41 signaling signal VBG cord-023095-4dannjjm 6446 42 through through IN cord-023095-4dannjjm 6446 43 the the DT cord-023095-4dannjjm 6446 44 p38 p38 CD cord-023095-4dannjjm 6446 45 mitogenactivated mitogenactivated JJ cord-023095-4dannjjm 6446 46 protein protein NN cord-023095-4dannjjm 6446 47 kinase kinase NN cord-023095-4dannjjm 6446 48 ( ( -LRB- cord-023095-4dannjjm 6446 49 MAPK MAPK NNP cord-023095-4dannjjm 6446 50 ) ) -RRB- cord-023095-4dannjjm 6446 51 pathway pathway NN cord-023095-4dannjjm 6446 52 . . . cord-023095-4dannjjm 6447 1 Peripheral peripheral JJ cord-023095-4dannjjm 6447 2 mononuclear mononuclear NN cord-023095-4dannjjm 6447 3 cells cell NNS cord-023095-4dannjjm 6447 4 ( ( -LRB- cord-023095-4dannjjm 6447 5 5 5 CD cord-023095-4dannjjm 6447 6 Â â CD cord-023095-4dannjjm 6447 7 10 10 CD cord-023095-4dannjjm 6447 8 6 6 CD cord-023095-4dannjjm 6447 9 ) ) -RRB- cord-023095-4dannjjm 6447 10 isolated isolate VBN cord-023095-4dannjjm 6447 11 from from IN cord-023095-4dannjjm 6447 12 buffy buffy NNP cord-023095-4dannjjm 6447 13 coat coat NN cord-023095-4dannjjm 6447 14 cells cell NNS cord-023095-4dannjjm 6447 15 of of IN cord-023095-4dannjjm 6447 16 healthy healthy JJ cord-023095-4dannjjm 6447 17 neonatal neonatal NN cord-023095-4dannjjm 6447 18 to to IN cord-023095-4dannjjm 6447 19 4-month 4-month JJ cord-023095-4dannjjm 6447 20 old old JJ cord-023095-4dannjjm 6447 21 Holstein Holstein NNP cord-023095-4dannjjm 6447 22 calves calf NNS cord-023095-4dannjjm 6447 23 were be VBD cord-023095-4dannjjm 6447 24 cultured culture VBN cord-023095-4dannjjm 6447 25 in in IN cord-023095-4dannjjm 6447 26 the the DT cord-023095-4dannjjm 6447 27 presence presence NN cord-023095-4dannjjm 6447 28 and and CC cord-023095-4dannjjm 6447 29 absence absence NN cord-023095-4dannjjm 6447 30 of of IN cord-023095-4dannjjm 6447 31 LF lf NN cord-023095-4dannjjm 6447 32 ( ( -LRB- cord-023095-4dannjjm 6447 33 200 200 CD cord-023095-4dannjjm 6447 34 ng ng NN cord-023095-4dannjjm 6447 35 / / SYM cord-023095-4dannjjm 6447 36 ml ml NNP cord-023095-4dannjjm 6447 37 ) ) -RRB- cord-023095-4dannjjm 6447 38 , , , cord-023095-4dannjjm 6447 39 LPS LPS NNP cord-023095-4dannjjm 6447 40 ( ( -LRB- cord-023095-4dannjjm 6447 41 1 1 CD cord-023095-4dannjjm 6447 42 mg mg NNP cord-023095-4dannjjm 6447 43 / / SYM cord-023095-4dannjjm 6447 44 ml ml NNP cord-023095-4dannjjm 6447 45 ) ) -RRB- cord-023095-4dannjjm 6447 46 , , , cord-023095-4dannjjm 6447 47 anisomycin anisomycin NNP cord-023095-4dannjjm 6447 48 ( ( -LRB- cord-023095-4dannjjm 6447 49 25 25 CD cord-023095-4dannjjm 6447 50 mg mg NNP cord-023095-4dannjjm 6447 51 / / SYM cord-023095-4dannjjm 6447 52 ml ml NNP cord-023095-4dannjjm 6447 53 ) ) -RRB- cord-023095-4dannjjm 6447 54 , , , cord-023095-4dannjjm 6447 55 a a DT cord-023095-4dannjjm 6447 56 known know VBN cord-023095-4dannjjm 6447 57 p38 p38 CD cord-023095-4dannjjm 6447 58 activator activator NN cord-023095-4dannjjm 6447 59 -the -the NFP cord-023095-4dannjjm 6447 60 positive positive JJ cord-023095-4dannjjm 6447 61 control control NN cord-023095-4dannjjm 6447 62 , , , cord-023095-4dannjjm 6447 63 and and CC cord-023095-4dannjjm 6447 64 50 50 CD cord-023095-4dannjjm 6447 65 mM mm CD cord-023095-4dannjjm 6447 66 of of IN cord-023095-4dannjjm 6447 67 SB203580 sb203580 NN cord-023095-4dannjjm 6447 68 , , , cord-023095-4dannjjm 6447 69 a a DT cord-023095-4dannjjm 6447 70 known know VBN cord-023095-4dannjjm 6447 71 p38 p38 CD cord-023095-4dannjjm 6447 72 inhibitor inhibitor NN cord-023095-4dannjjm 6447 73 -the -the DT cord-023095-4dannjjm 6447 74 negative negative JJ cord-023095-4dannjjm 6447 75 control control NN cord-023095-4dannjjm 6447 76 . . . cord-023095-4dannjjm 6448 1 Sample sample JJ cord-023095-4dannjjm 6448 2 lysates lysate NNS cord-023095-4dannjjm 6448 3 obtained obtain VBD cord-023095-4dannjjm 6448 4 post post NN cord-023095-4dannjjm 6448 5 culture culture NN cord-023095-4dannjjm 6448 6 was be VBD cord-023095-4dannjjm 6448 7 subjected subject VBN cord-023095-4dannjjm 6448 8 to to IN cord-023095-4dannjjm 6448 9 immunoprecipitation immunoprecipitation NN cord-023095-4dannjjm 6448 10 and and CC cord-023095-4dannjjm 6448 11 kinase kinase NN cord-023095-4dannjjm 6448 12 reactions reaction NNS cord-023095-4dannjjm 6448 13 . . . cord-023095-4dannjjm 6449 1 Reactions reaction NNS cord-023095-4dannjjm 6449 2 were be VBD cord-023095-4dannjjm 6449 3 terminated terminate VBN cord-023095-4dannjjm 6449 4 under under IN cord-023095-4dannjjm 6449 5 reducing reduce VBG cord-023095-4dannjjm 6449 6 conditions condition NNS cord-023095-4dannjjm 6449 7 and and CC cord-023095-4dannjjm 6449 8 evaluated evaluate VBN cord-023095-4dannjjm 6449 9 using use VBG cord-023095-4dannjjm 6449 10 western western JJ cord-023095-4dannjjm 6449 11 immunoblotting immunoblotting NN cord-023095-4dannjjm 6449 12 . . . cord-023095-4dannjjm 6450 1 Phosphorylation Phosphorylation NNP cord-023095-4dannjjm 6450 2 of of IN cord-023095-4dannjjm 6450 3 activated activate VBN cord-023095-4dannjjm 6450 4 transcription transcription NN cord-023095-4dannjjm 6450 5 factor-2 factor-2 NNP cord-023095-4dannjjm 6450 6 ( ( -LRB- cord-023095-4dannjjm 6450 7 ATF-2 ATF-2 NNP cord-023095-4dannjjm 6450 8 ) ) -RRB- cord-023095-4dannjjm 6450 9 by by IN cord-023095-4dannjjm 6450 10 phosphorylated phosphorylated JJ cord-023095-4dannjjm 6450 11 p38 p38 NN cord-023095-4dannjjm 6450 12 served serve VBD cord-023095-4dannjjm 6450 13 as as IN cord-023095-4dannjjm 6450 14 the the DT cord-023095-4dannjjm 6450 15 marker marker NN cord-023095-4dannjjm 6450 16 of of IN cord-023095-4dannjjm 6450 17 investigation investigation NN cord-023095-4dannjjm 6450 18 . . . cord-023095-4dannjjm 6451 1 Immunologically immunologically RB cord-023095-4dannjjm 6451 2 reactive reactive JJ cord-023095-4dannjjm 6451 3 ATF-2 ATF-2 NNP cord-023095-4dannjjm 6451 4 expression expression NN cord-023095-4dannjjm 6451 5 by by IN cord-023095-4dannjjm 6451 6 LPS LPS NNP cord-023095-4dannjjm 6451 7 and and CC cord-023095-4dannjjm 6451 8 anisomycin anisomycin NNS cord-023095-4dannjjm 6451 9 - - HYPH cord-023095-4dannjjm 6451 10 treated treat VBN cord-023095-4dannjjm 6451 11 cells cell NNS cord-023095-4dannjjm 6451 12 was be VBD cord-023095-4dannjjm 6451 13 compatible compatible JJ cord-023095-4dannjjm 6451 14 with with IN cord-023095-4dannjjm 6451 15 a a DT cord-023095-4dannjjm 6451 16 prominent prominent JJ cord-023095-4dannjjm 6451 17 band band NN cord-023095-4dannjjm 6451 18 at at IN cord-023095-4dannjjm 6451 19 40 40 CD cord-023095-4dannjjm 6451 20 kD. kd. JJ cord-023095-4dannjjm 6451 21 Evidence evidence NN cord-023095-4dannjjm 6451 22 of of IN cord-023095-4dannjjm 6451 23 LF lf NN cord-023095-4dannjjm 6451 24 - - HYPH cord-023095-4dannjjm 6451 25 induced induce VBN cord-023095-4dannjjm 6451 26 inhibition inhibition NN cord-023095-4dannjjm 6451 27 of of IN cord-023095-4dannjjm 6451 28 LPS LPS NNP cord-023095-4dannjjm 6451 29 - - HYPH cord-023095-4dannjjm 6451 30 induced induce VBN cord-023095-4dannjjm 6451 31 p-38 p-38 NNP cord-023095-4dannjjm 6451 32 activation activation NN cord-023095-4dannjjm 6451 33 was be VBD cord-023095-4dannjjm 6451 34 observed observe VBN cord-023095-4dannjjm 6451 35 in in IN cord-023095-4dannjjm 6451 36 lanes lane NNS cord-023095-4dannjjm 6451 37 representative representative NN cord-023095-4dannjjm 6451 38 of of IN cord-023095-4dannjjm 6451 39 co co NNS cord-023095-4dannjjm 6451 40 - - NNS cord-023095-4dannjjm 6451 41 cultures culture NNS cord-023095-4dannjjm 6451 42 of of IN cord-023095-4dannjjm 6451 43 LF lf NN cord-023095-4dannjjm 6451 44 1 1 CD cord-023095-4dannjjm 6451 45 LPS lp NNS cord-023095-4dannjjm 6451 46 ; ; : cord-023095-4dannjjm 6451 47 LF LF NNP cord-023095-4dannjjm 6451 48 1 1 CD cord-023095-4dannjjm 6451 49 anisomycin anisomycin NN cord-023095-4dannjjm 6451 50 ; ; : cord-023095-4dannjjm 6451 51 and and CC cord-023095-4dannjjm 6451 52 anisomycin anisomycin NN cord-023095-4dannjjm 6451 53 1 1 CD cord-023095-4dannjjm 6451 54 SB203580 sb203580 NN cord-023095-4dannjjm 6451 55 , , , cord-023095-4dannjjm 6451 56 which which WDT cord-023095-4dannjjm 6451 57 was be VBD cord-023095-4dannjjm 6451 58 demonstrated demonstrate VBN cord-023095-4dannjjm 6451 59 by by IN cord-023095-4dannjjm 6451 60 decreased decrease VBN cord-023095-4dannjjm 6451 61 immunological immunological JJ cord-023095-4dannjjm 6451 62 reactivity reactivity NN cord-023095-4dannjjm 6451 63 at at IN cord-023095-4dannjjm 6451 64 40kD. 40kd. CD cord-023095-4dannjjm 6452 1 The the DT cord-023095-4dannjjm 6452 2 findings finding NNS cord-023095-4dannjjm 6452 3 here here RB cord-023095-4dannjjm 6452 4 , , , cord-023095-4dannjjm 6452 5 suggest suggest VBP cord-023095-4dannjjm 6452 6 that that IN cord-023095-4dannjjm 6452 7 LF LF NNP cord-023095-4dannjjm 6452 8 interferes interfere VBZ cord-023095-4dannjjm 6452 9 with with IN cord-023095-4dannjjm 6452 10 LPS LPS NNP cord-023095-4dannjjm 6452 11 - - HYPH cord-023095-4dannjjm 6452 12 induced induce VBN cord-023095-4dannjjm 6452 13 p-38 p-38 NNP cord-023095-4dannjjm 6452 14 activation activation NN cord-023095-4dannjjm 6452 15 of of IN cord-023095-4dannjjm 6452 16 transcription transcription NN cord-023095-4dannjjm 6452 17 factor factor NN cord-023095-4dannjjm 6452 18 ATF-2 ATF-2 NNP cord-023095-4dannjjm 6452 19 , , , cord-023095-4dannjjm 6452 20 in in IN cord-023095-4dannjjm 6452 21 vitro vitro FW cord-023095-4dannjjm 6452 22 . . . cord-023095-4dannjjm 6453 1 This this DT cord-023095-4dannjjm 6453 2 serves serve VBZ cord-023095-4dannjjm 6453 3 as as IN cord-023095-4dannjjm 6453 4 additional additional JJ cord-023095-4dannjjm 6453 5 proof proof NN cord-023095-4dannjjm 6453 6 of of IN cord-023095-4dannjjm 6453 7 its -PRON- PRP$ cord-023095-4dannjjm 6453 8 potential potential JJ cord-023095-4dannjjm 6453 9 use use NN cord-023095-4dannjjm 6453 10 in in IN cord-023095-4dannjjm 6453 11 attenuating attenuate VBG cord-023095-4dannjjm 6453 12 the the DT cord-023095-4dannjjm 6453 13 systemic systemic JJ cord-023095-4dannjjm 6453 14 effects effect NNS cord-023095-4dannjjm 6453 15 of of IN cord-023095-4dannjjm 6453 16 LPS lp NNS cord-023095-4dannjjm 6453 17 . . . cord-023095-4dannjjm 6454 1 Six six CD cord-023095-4dannjjm 6454 2 ( ( -LRB- cord-023095-4dannjjm 6454 3 6 6 LS cord-023095-4dannjjm 6454 4 ) ) -RRB- cord-023095-4dannjjm 6454 5 clinically clinically RB cord-023095-4dannjjm 6454 6 normal normal JJ cord-023095-4dannjjm 6454 7 , , , cord-023095-4dannjjm 6454 8 purpose purpose NN cord-023095-4dannjjm 6454 9 - - HYPH cord-023095-4dannjjm 6454 10 bred breed VBN cord-023095-4dannjjm 6454 11 cats cat NNS cord-023095-4dannjjm 6454 12 of of IN cord-023095-4dannjjm 6454 13 similar similar JJ cord-023095-4dannjjm 6454 14 age age NN cord-023095-4dannjjm 6454 15 and and CC cord-023095-4dannjjm 6454 16 body body NN cord-023095-4dannjjm 6454 17 condition condition NN cord-023095-4dannjjm 6454 18 were be VBD cord-023095-4dannjjm 6454 19 imaged image VBN cord-023095-4dannjjm 6454 20 with with IN cord-023095-4dannjjm 6454 21 [ [ -LRB- cord-023095-4dannjjm 6454 22 18 18 CD cord-023095-4dannjjm 6454 23 F F NNP cord-023095-4dannjjm 6454 24 ] ] -RRB- cord-023095-4dannjjm 6454 25 fluorodeoxyglucose fluorodeoxyglucose NNP cord-023095-4dannjjm 6454 26 ( ( -LRB- cord-023095-4dannjjm 6454 27 [ [ -LRB- cord-023095-4dannjjm 6454 28 18 18 CD cord-023095-4dannjjm 6454 29 F]FDG f]fdg NN cord-023095-4dannjjm 6454 30 ) ) -RRB- cord-023095-4dannjjm 6454 31 and and CC cord-023095-4dannjjm 6454 32 [ [ -LRB- cord-023095-4dannjjm 6454 33 18 18 CD cord-023095-4dannjjm 6455 1 F]FTHA F]FTHA NNP cord-023095-4dannjjm 6455 2 by by IN cord-023095-4dannjjm 6455 3 using use VBG cord-023095-4dannjjm 6455 4 dynamic dynamic JJ cord-023095-4dannjjm 6455 5 cardiac cardiac NN cord-023095-4dannjjm 6455 6 - - HYPH cord-023095-4dannjjm 6455 7 gated gated JJ cord-023095-4dannjjm 6455 8 fused fuse VBN cord-023095-4dannjjm 6455 9 PET PET NNP cord-023095-4dannjjm 6455 10 / / SYM cord-023095-4dannjjm 6455 11 CT CT NNP cord-023095-4dannjjm 6455 12 for for IN cord-023095-4dannjjm 6455 13 kinetic kinetic JJ cord-023095-4dannjjm 6455 14 assessment assessment NN cord-023095-4dannjjm 6455 15 of of IN cord-023095-4dannjjm 6455 16 myocardial myocardial JJ cord-023095-4dannjjm 6455 17 glucose glucose NN cord-023095-4dannjjm 6455 18 and and CC cord-023095-4dannjjm 6455 19 fatty fatty JJ cord-023095-4dannjjm 6455 20 acid acid NN cord-023095-4dannjjm 6455 21 uptake uptake NN cord-023095-4dannjjm 6455 22 and and CC cord-023095-4dannjjm 6455 23 metabolism metabolism NN cord-023095-4dannjjm 6455 24 , , , cord-023095-4dannjjm 6455 25 respectively respectively RB cord-023095-4dannjjm 6455 26 . . . cord-023095-4dannjjm 6456 1 Kinetic kinetic JJ cord-023095-4dannjjm 6456 2 tracer tracer NN cord-023095-4dannjjm 6456 3 uptake uptake NN cord-023095-4dannjjm 6456 4 within within IN cord-023095-4dannjjm 6456 5 the the DT cord-023095-4dannjjm 6456 6 myocardium myocardium NN cord-023095-4dannjjm 6456 7 was be VBD cord-023095-4dannjjm 6456 8 achieved achieve VBN cord-023095-4dannjjm 6456 9 by by IN cord-023095-4dannjjm 6456 10 initiating initiate VBG cord-023095-4dannjjm 6456 11 image image NN cord-023095-4dannjjm 6456 12 data datum NNS cord-023095-4dannjjm 6456 13 acquisition acquisition NN cord-023095-4dannjjm 6456 14 simultaneously simultaneously RB cord-023095-4dannjjm 6456 15 with with IN cord-023095-4dannjjm 6456 16 tracer tracer NN cord-023095-4dannjjm 6456 17 injection injection NN cord-023095-4dannjjm 6456 18 . . . cord-023095-4dannjjm 6457 1 PET PET NNP cord-023095-4dannjjm 6457 2 data datum NNS cord-023095-4dannjjm 6457 3 were be VBD cord-023095-4dannjjm 6457 4 acquired acquire VBN cord-023095-4dannjjm 6457 5 over over IN cord-023095-4dannjjm 6457 6 a a DT cord-023095-4dannjjm 6457 7 1 1 CD cord-023095-4dannjjm 6457 8 hour hour NN cord-023095-4dannjjm 6457 9 period period NN cord-023095-4dannjjm 6457 10 with with IN cord-023095-4dannjjm 6457 11 the the DT cord-023095-4dannjjm 6457 12 heart heart NN cord-023095-4dannjjm 6457 13 in in IN cord-023095-4dannjjm 6457 14 the the DT cord-023095-4dannjjm 6457 15 center center NN cord-023095-4dannjjm 6457 16 of of IN cord-023095-4dannjjm 6457 17 the the DT cord-023095-4dannjjm 6457 18 scanner scanner NN cord-023095-4dannjjm 6457 19 field field NN cord-023095-4dannjjm 6457 20 of of IN cord-023095-4dannjjm 6457 21 view view NN cord-023095-4dannjjm 6457 22 . . . cord-023095-4dannjjm 6458 1 Regions region NNS cord-023095-4dannjjm 6458 2 of of IN cord-023095-4dannjjm 6458 3 interest interest NN cord-023095-4dannjjm 6458 4 were be VBD cord-023095-4dannjjm 6458 5 drawn draw VBN cord-023095-4dannjjm 6458 6 in in IN cord-023095-4dannjjm 6458 7 the the DT cord-023095-4dannjjm 6458 8 left left JJ cord-023095-4dannjjm 6458 9 ventricular ventricular JJ cord-023095-4dannjjm 6458 10 wall wall NN cord-023095-4dannjjm 6458 11 and and CC cord-023095-4dannjjm 6458 12 thoracic thoracic JJ cord-023095-4dannjjm 6458 13 aorta aorta NN cord-023095-4dannjjm 6458 14 for for IN cord-023095-4dannjjm 6458 15 the the DT cord-023095-4dannjjm 6458 16 purpose purpose NN cord-023095-4dannjjm 6458 17 of of IN cord-023095-4dannjjm 6458 18 measuring measure VBG cord-023095-4dannjjm 6458 19 the the DT cord-023095-4dannjjm 6458 20 kinetics kinetic NNS cord-023095-4dannjjm 6458 21 of of IN cord-023095-4dannjjm 6458 22 tracer tracer NN cord-023095-4dannjjm 6458 23 redistribution redistribution NN cord-023095-4dannjjm 6458 24 . . . cord-023095-4dannjjm 6459 1 Serial serial JJ cord-023095-4dannjjm 6459 2 blood blood NN cord-023095-4dannjjm 6459 3 samples sample NNS cord-023095-4dannjjm 6459 4 were be VBD cord-023095-4dannjjm 6459 5 also also RB cord-023095-4dannjjm 6459 6 taken take VBN cord-023095-4dannjjm 6459 7 during during IN cord-023095-4dannjjm 6459 8 PET pet JJ cord-023095-4dannjjm 6459 9 imaging imaging NN cord-023095-4dannjjm 6459 10 for for IN cord-023095-4dannjjm 6459 11 comparison comparison NN cord-023095-4dannjjm 6459 12 with with IN cord-023095-4dannjjm 6459 13 image image NN cord-023095-4dannjjm 6459 14 data datum NNS cord-023095-4dannjjm 6459 15 . . . cord-023095-4dannjjm 6460 1 The the DT cord-023095-4dannjjm 6460 2 equilibrium equilibrium NN cord-023095-4dannjjm 6460 3 biodistribution biodistribution NN cord-023095-4dannjjm 6460 4 of of IN cord-023095-4dannjjm 6460 5 both both DT cord-023095-4dannjjm 6460 6 tracers tracer NNS cord-023095-4dannjjm 6460 7 was be VBD cord-023095-4dannjjm 6460 8 documented document VBN cord-023095-4dannjjm 6460 9 1 1 CD cord-023095-4dannjjm 6460 10 hour hour NN cord-023095-4dannjjm 6460 11 post post NN cord-023095-4dannjjm 6460 12 - - NN cord-023095-4dannjjm 6460 13 injection injection NN cord-023095-4dannjjm 6460 14 in in IN cord-023095-4dannjjm 6460 15 a a DT cord-023095-4dannjjm 6460 16 whole whole JJ cord-023095-4dannjjm 6460 17 body body NN cord-023095-4dannjjm 6460 18 PET PET NNP cord-023095-4dannjjm 6460 19 / / SYM cord-023095-4dannjjm 6460 20 CT CT NNP cord-023095-4dannjjm 6460 21 image image NN cord-023095-4dannjjm 6460 22 . . . cord-023095-4dannjjm 6461 1 Standard standard JJ cord-023095-4dannjjm 6461 2 echocardiographic echocardiographic JJ cord-023095-4dannjjm 6461 3 examination examination NN cord-023095-4dannjjm 6461 4 of of IN cord-023095-4dannjjm 6461 5 cardiac cardiac JJ cord-023095-4dannjjm 6461 6 structures structure NNS cord-023095-4dannjjm 6461 7 was be VBD cord-023095-4dannjjm 6461 8 also also RB cord-023095-4dannjjm 6461 9 performed perform VBN cord-023095-4dannjjm 6461 10 . . . cord-023095-4dannjjm 6462 1 Both both DT cord-023095-4dannjjm 6462 2 radiotracers radiotracer NNS cord-023095-4dannjjm 6462 3 remained remain VBD cord-023095-4dannjjm 6462 4 in in IN cord-023095-4dannjjm 6462 5 the the DT cord-023095-4dannjjm 6462 6 plasma plasma NN cord-023095-4dannjjm 6462 7 fraction fraction NN cord-023095-4dannjjm 6462 8 ; ; : cord-023095-4dannjjm 6462 9 however however RB cord-023095-4dannjjm 6462 10 , , , cord-023095-4dannjjm 6462 11 [ [ -LRB- cord-023095-4dannjjm 6462 12 18 18 CD cord-023095-4dannjjm 6463 1 F]FTHA F]FTHA NNP cord-023095-4dannjjm 6463 2 was be VBD cord-023095-4dannjjm 6463 3 cleared clear VBN cord-023095-4dannjjm 6463 4 from from IN cord-023095-4dannjjm 6463 5 the the DT cord-023095-4dannjjm 6463 6 more more RBR cord-023095-4dannjjm 6463 7 rapidly rapidly RB cord-023095-4dannjjm 6463 8 than than IN cord-023095-4dannjjm 6463 9 [ [ -LRB- cord-023095-4dannjjm 6463 10 18 18 CD cord-023095-4dannjjm 6463 11 F]FDG f]fdg NN cord-023095-4dannjjm 6463 12 ( ( -LRB- cord-023095-4dannjjm 6463 13 t t NN cord-023095-4dannjjm 6463 14 1/2 1/2 CD cord-023095-4dannjjm 6463 15 $ $ $ cord-023095-4dannjjm 6463 16 2 2 CD cord-023095-4dannjjm 6463 17 and and CC cord-023095-4dannjjm 6463 18 $ $ $ cord-023095-4dannjjm 6463 19 20 20 CD cord-023095-4dannjjm 6463 20 min min NN cord-023095-4dannjjm 6463 21 , , , cord-023095-4dannjjm 6463 22 respectively respectively RB cord-023095-4dannjjm 6463 23 ) ) -RRB- cord-023095-4dannjjm 6463 24 . . . cord-023095-4dannjjm 6464 1 The the DT cord-023095-4dannjjm 6464 2 tracers tracer NNS cord-023095-4dannjjm 6464 3 were be VBD cord-023095-4dannjjm 6464 4 readily readily RB cord-023095-4dannjjm 6464 5 visualized visualize VBN cord-023095-4dannjjm 6464 6 within within IN cord-023095-4dannjjm 6464 7 the the DT cord-023095-4dannjjm 6464 8 feline feline JJ cord-023095-4dannjjm 6464 9 myocardium myocardium NN cord-023095-4dannjjm 6464 10 in in IN cord-023095-4dannjjm 6464 11 dynamic dynamic JJ cord-023095-4dannjjm 6464 12 PET pet JJ cord-023095-4dannjjm 6464 13 images image NNS cord-023095-4dannjjm 6464 14 and and CC cord-023095-4dannjjm 6464 15 analysis analysis NN cord-023095-4dannjjm 6464 16 of of IN cord-023095-4dannjjm 6464 17 the the DT cord-023095-4dannjjm 6464 18 blood blood NN cord-023095-4dannjjm 6464 19 pool pool NN cord-023095-4dannjjm 6464 20 clearance clearance NN cord-023095-4dannjjm 6464 21 from from IN cord-023095-4dannjjm 6464 22 the the DT cord-023095-4dannjjm 6464 23 kinetic kinetic JJ cord-023095-4dannjjm 6464 24 image image NN cord-023095-4dannjjm 6464 25 data datum NNS cord-023095-4dannjjm 6464 26 agreed agree VBD cord-023095-4dannjjm 6464 27 with with IN cord-023095-4dannjjm 6464 28 blood blood NN cord-023095-4dannjjm 6464 29 sampling sampling NN cord-023095-4dannjjm 6464 30 data datum NNS cord-023095-4dannjjm 6464 31 . . . cord-023095-4dannjjm 6465 1 Myocardial myocardial JJ cord-023095-4dannjjm 6465 2 uptake uptake NN cord-023095-4dannjjm 6465 3 of of IN cord-023095-4dannjjm 6465 4 each each DT cord-023095-4dannjjm 6465 5 tracer tracer NN cord-023095-4dannjjm 6465 6 was be VBD cord-023095-4dannjjm 6465 7 best well RBS cord-023095-4dannjjm 6465 8 described describe VBN cord-023095-4dannjjm 6465 9 by by IN cord-023095-4dannjjm 6465 10 a a DT cord-023095-4dannjjm 6465 11 double double JJ cord-023095-4dannjjm 6465 12 exponential exponential JJ cord-023095-4dannjjm 6465 13 analysis analysis NN cord-023095-4dannjjm 6465 14 and and CC cord-023095-4dannjjm 6465 15 was be VBD cord-023095-4dannjjm 6465 16 rapid rapid JJ cord-023095-4dannjjm 6465 17 but but CC cord-023095-4dannjjm 6465 18 variable variable JJ cord-023095-4dannjjm 6465 19 among among IN cord-023095-4dannjjm 6465 20 animals animal NNS cord-023095-4dannjjm 6465 21 ( ( -LRB- cord-023095-4dannjjm 6465 22 range range VBP cord-023095-4dannjjm 6465 23 1 1 CD cord-023095-4dannjjm 6465 24 - - SYM cord-023095-4dannjjm 6465 25 30 30 CD cord-023095-4dannjjm 6465 26 Bq Bq NNP cord-023095-4dannjjm 6465 27 / / SYM cord-023095-4dannjjm 6465 28 cc cc NN cord-023095-4dannjjm 6465 29 / / SYM cord-023095-4dannjjm 6465 30 min min NNP cord-023095-4dannjjm 6465 31 ) ) -RRB- cord-023095-4dannjjm 6465 32 , , , cord-023095-4dannjjm 6465 33 although although IN cord-023095-4dannjjm 6465 34 blood blood NN cord-023095-4dannjjm 6465 35 glucose glucose NN cord-023095-4dannjjm 6465 36 levels level NNS cord-023095-4dannjjm 6465 37 were be VBD cord-023095-4dannjjm 6465 38 similar similar JJ cord-023095-4dannjjm 6465 39 in in IN cord-023095-4dannjjm 6465 40 all all DT cord-023095-4dannjjm 6465 41 cats cat NNS cord-023095-4dannjjm 6465 42 during during IN cord-023095-4dannjjm 6465 43 image image NN cord-023095-4dannjjm 6465 44 acquisition acquisition NN cord-023095-4dannjjm 6465 45 . . . cord-023095-4dannjjm 6466 1 Physiologic physiologic JJ cord-023095-4dannjjm 6466 2 [ [ -LRB- cord-023095-4dannjjm 6466 3 18 18 CD cord-023095-4dannjjm 6466 4 F]FDG f]fdg NN cord-023095-4dannjjm 6466 5 was be VBD cord-023095-4dannjjm 6466 6 observed observe VBN cord-023095-4dannjjm 6466 7 in in IN cord-023095-4dannjjm 6466 8 the the DT cord-023095-4dannjjm 6466 9 brain brain NN cord-023095-4dannjjm 6466 10 , , , cord-023095-4dannjjm 6466 11 salivary salivary JJ cord-023095-4dannjjm 6466 12 tissue tissue NN cord-023095-4dannjjm 6466 13 , , , cord-023095-4dannjjm 6466 14 gastrointestinal gastrointestinal JJ cord-023095-4dannjjm 6466 15 tract tract NN cord-023095-4dannjjm 6466 16 , , , cord-023095-4dannjjm 6466 17 renal renal JJ cord-023095-4dannjjm 6466 18 pelves pelvis NNS cord-023095-4dannjjm 6466 19 and and CC cord-023095-4dannjjm 6466 20 urinary urinary JJ cord-023095-4dannjjm 6466 21 bladder bladder NN cord-023095-4dannjjm 6466 22 , , , cord-023095-4dannjjm 6466 23 with with IN cord-023095-4dannjjm 6467 1 [ [ -LRB- cord-023095-4dannjjm 6467 2 18 18 CD cord-023095-4dannjjm 6467 3 F]FTHA F]FTHA NNP cord-023095-4dannjjm 6467 4 seen see VBN cord-023095-4dannjjm 6467 5 in in IN cord-023095-4dannjjm 6467 6 the the DT cord-023095-4dannjjm 6467 7 myocardium myocardium NN cord-023095-4dannjjm 6467 8 , , , cord-023095-4dannjjm 6467 9 liver liver NN cord-023095-4dannjjm 6467 10 and and CC cord-023095-4dannjjm 6467 11 renal renal JJ cord-023095-4dannjjm 6467 12 cortex cortex NNS cord-023095-4dannjjm 6467 13 . . . cord-023095-4dannjjm 6468 1 All all DT cord-023095-4dannjjm 6468 2 cats cat NNS cord-023095-4dannjjm 6468 3 were be VBD cord-023095-4dannjjm 6468 4 normotensive normotensive VBN cord-023095-4dannjjm 6468 5 with with IN cord-023095-4dannjjm 6468 6 normal normal JJ cord-023095-4dannjjm 6468 7 echocardiographic echocardiographic JJ cord-023095-4dannjjm 6468 8 parameters parameter NNS cord-023095-4dannjjm 6468 9 . . . cord-023095-4dannjjm 6469 1 This this DT cord-023095-4dannjjm 6469 2 study study NN cord-023095-4dannjjm 6469 3 demonstrates demonstrate VBZ cord-023095-4dannjjm 6469 4 the the DT cord-023095-4dannjjm 6469 5 utility utility NN cord-023095-4dannjjm 6469 6 of of IN cord-023095-4dannjjm 6469 7 kinetic kinetic JJ cord-023095-4dannjjm 6469 8 imaging imaging NN cord-023095-4dannjjm 6469 9 using use VBG cord-023095-4dannjjm 6469 10 The the DT cord-023095-4dannjjm 6469 11 left left JJ cord-023095-4dannjjm 6469 12 ventricle ventricle NN cord-023095-4dannjjm 6469 13 ( ( -LRB- cord-023095-4dannjjm 6469 14 LV LV NNP cord-023095-4dannjjm 6469 15 ) ) -RRB- cord-023095-4dannjjm 6469 16 shape shape NN cord-023095-4dannjjm 6469 17 has have VBZ cord-023095-4dannjjm 6469 18 been be VBN cord-023095-4dannjjm 6469 19 suggested suggest VBN cord-023095-4dannjjm 6469 20 to to TO cord-023095-4dannjjm 6469 21 change change VB cord-023095-4dannjjm 6469 22 from from IN cord-023095-4dannjjm 6469 23 elliptical elliptical JJ cord-023095-4dannjjm 6469 24 to to IN cord-023095-4dannjjm 6469 25 more more RBR cord-023095-4dannjjm 6469 26 globular globular JJ cord-023095-4dannjjm 6469 27 in in IN cord-023095-4dannjjm 6469 28 response response NN cord-023095-4dannjjm 6469 29 to to IN cord-023095-4dannjjm 6469 30 chronic chronic JJ cord-023095-4dannjjm 6469 31 volume volume NN cord-023095-4dannjjm 6469 32 overload overload NN cord-023095-4dannjjm 6469 33 . . . cord-023095-4dannjjm 6470 1 Real real JJ cord-023095-4dannjjm 6470 2 - - HYPH cord-023095-4dannjjm 6470 3 time time NN cord-023095-4dannjjm 6470 4 three three CD cord-023095-4dannjjm 6470 5 - - HYPH cord-023095-4dannjjm 6470 6 dimensional dimensional JJ cord-023095-4dannjjm 6470 7 echocardiography echocardiography NN cord-023095-4dannjjm 6470 8 ( ( -LRB- cord-023095-4dannjjm 6470 9 RT3DE RT3DE NNP cord-023095-4dannjjm 6470 10 ) ) -RRB- cord-023095-4dannjjm 6470 11 offers offer VBZ cord-023095-4dannjjm 6470 12 new new JJ cord-023095-4dannjjm 6470 13 modalities modality NNS cord-023095-4dannjjm 6470 14 for for IN cord-023095-4dannjjm 6470 15 LV LV NNP cord-023095-4dannjjm 6470 16 assessment assessment NN cord-023095-4dannjjm 6470 17 . . . cord-023095-4dannjjm 6471 1 The the DT cord-023095-4dannjjm 6471 2 aim aim NN cord-023095-4dannjjm 6471 3 of of IN cord-023095-4dannjjm 6471 4 the the DT cord-023095-4dannjjm 6471 5 study study NN cord-023095-4dannjjm 6471 6 was be VBD cord-023095-4dannjjm 6471 7 to to TO cord-023095-4dannjjm 6471 8 investigate investigate VB cord-023095-4dannjjm 6471 9 left leave VBN cord-023095-4dannjjm 6471 10 ventricular ventricular JJ cord-023095-4dannjjm 6471 11 changes change NNS cord-023095-4dannjjm 6471 12 in in IN cord-023095-4dannjjm 6471 13 shape shape NN cord-023095-4dannjjm 6471 14 and and CC cord-023095-4dannjjm 6471 15 volume volume NN cord-023095-4dannjjm 6471 16 occurring occur VBG cord-023095-4dannjjm 6471 17 in in IN cord-023095-4dannjjm 6471 18 response response NN cord-023095-4dannjjm 6471 19 to to IN cord-023095-4dannjjm 6471 20 different different JJ cord-023095-4dannjjm 6471 21 severities severity NNS cord-023095-4dannjjm 6471 22 of of IN cord-023095-4dannjjm 6471 23 naturally naturally RB cord-023095-4dannjjm 6471 24 acquired acquire VBN cord-023095-4dannjjm 6471 25 myxomatous myxomatous JJ cord-023095-4dannjjm 6471 26 mitral mitral JJ cord-023095-4dannjjm 6471 27 valve valve NN cord-023095-4dannjjm 6471 28 disease disease NN cord-023095-4dannjjm 6471 29 ( ( -LRB- cord-023095-4dannjjm 6471 30 MMVD MMVD NNP cord-023095-4dannjjm 6471 31 ) ) -RRB- cord-023095-4dannjjm 6471 32 in in IN cord-023095-4dannjjm 6471 33 dogs dog NNS cord-023095-4dannjjm 6471 34 using use VBG cord-023095-4dannjjm 6471 35 RT3DE RT3DE NNS cord-023095-4dannjjm 6471 36 . . . cord-023095-4dannjjm 6472 1 Privately privately RB cord-023095-4dannjjm 6472 2 owned own VBN cord-023095-4dannjjm 6472 3 dogs dog NNS cord-023095-4dannjjm 6472 4 were be VBD cord-023095-4dannjjm 6472 5 classified classify VBN cord-023095-4dannjjm 6472 6 by by IN cord-023095-4dannjjm 6472 7 standard standard JJ cord-023095-4dannjjm 6472 8 echocardiography echocardiography NN cord-023095-4dannjjm 6472 9 into into IN cord-023095-4dannjjm 6472 10 : : : cord-023095-4dannjjm 6472 11 Healthy Healthy NNP cord-023095-4dannjjm 6472 12 ( ( -LRB- cord-023095-4dannjjm 6472 13 20 20 CD cord-023095-4dannjjm 6472 14 ) ) -RRB- cord-023095-4dannjjm 6472 15 , , , cord-023095-4dannjjm 6472 16 mild mild JJ cord-023095-4dannjjm 6472 17 ( ( -LRB- cord-023095-4dannjjm 6472 18 20 20 CD cord-023095-4dannjjm 6472 19 ) ) -RRB- cord-023095-4dannjjm 6472 20 , , , cord-023095-4dannjjm 6472 21 moderate moderate JJ cord-023095-4dannjjm 6472 22 ( ( -LRB- cord-023095-4dannjjm 6472 23 8) 8) NN cord-023095-4dannjjm 6472 24 and and CC cord-023095-4dannjjm 6472 25 severe severe JJ cord-023095-4dannjjm 6472 26 MMVD MMVD NNP cord-023095-4dannjjm 6472 27 ( ( -LRB- cord-023095-4dannjjm 6472 28 17 17 CD cord-023095-4dannjjm 6472 29 ) ) -RRB- cord-023095-4dannjjm 6472 30 . . . cord-023095-4dannjjm 6473 1 A a DT cord-023095-4dannjjm 6473 2 LV LV NNP cord-023095-4dannjjm 6473 3 cast cast NN cord-023095-4dannjjm 6473 4 was be VBD cord-023095-4dannjjm 6473 5 obtained obtain VBN cord-023095-4dannjjm 6473 6 using use VBG cord-023095-4dannjjm 6473 7 semi semi RB cord-023095-4dannjjm 6473 8 - - JJ cord-023095-4dannjjm 6473 9 automated automate VBN cord-023095-4dannjjm 6473 10 endocardial endocardial JJ cord-023095-4dannjjm 6473 11 border border NN cord-023095-4dannjjm 6473 12 tracking tracking NN cord-023095-4dannjjm 6473 13 from from IN cord-023095-4dannjjm 6473 14 RT3DE rt3de NN cord-023095-4dannjjm 6473 15 dataset dataset NN cord-023095-4dannjjm 6473 16 , , , cord-023095-4dannjjm 6473 17 from from IN cord-023095-4dannjjm 6473 18 which which WDT cord-023095-4dannjjm 6473 19 global global JJ cord-023095-4dannjjm 6473 20 and and CC cord-023095-4dannjjm 6473 21 regional regional JJ cord-023095-4dannjjm 6473 22 ( ( -LRB- cord-023095-4dannjjm 6473 23 automatically automatically RB cord-023095-4dannjjm 6473 24 acquired acquire VBN cord-023095-4dannjjm 6473 25 basal basal NN cord-023095-4dannjjm 6473 26 , , , cord-023095-4dannjjm 6473 27 mid mid JJ cord-023095-4dannjjm 6473 28 , , , cord-023095-4dannjjm 6473 29 and and CC cord-023095-4dannjjm 6473 30 apical apical JJ cord-023095-4dannjjm 6473 31 segments segment NNS cord-023095-4dannjjm 6473 32 based base VBN cord-023095-4dannjjm 6473 33 on on IN cord-023095-4dannjjm 6473 34 LV LV NNP cord-023095-4dannjjm 6473 35 long long JJ cord-023095-4dannjjm 6473 36 - - HYPH cord-023095-4dannjjm 6473 37 axis axis NN cord-023095-4dannjjm 6473 38 dimension dimension NN cord-023095-4dannjjm 6473 39 ) ) -RRB- cord-023095-4dannjjm 6473 40 end end NN cord-023095-4dannjjm 6473 41 - - HYPH cord-023095-4dannjjm 6473 42 diastolic diastolic JJ cord-023095-4dannjjm 6473 43 ( ( -LRB- cord-023095-4dannjjm 6473 44 EDV EDV NNP cord-023095-4dannjjm 6473 45 ) ) -RRB- cord-023095-4dannjjm 6473 46 and and CC cord-023095-4dannjjm 6473 47 endsystolic endsystolic JJ cord-023095-4dannjjm 6473 48 volumes volume NNS cord-023095-4dannjjm 6473 49 ( ( -LRB- cord-023095-4dannjjm 6473 50 ESV ESV NNP cord-023095-4dannjjm 6473 51 ) ) -RRB- cord-023095-4dannjjm 6473 52 , , , cord-023095-4dannjjm 6473 53 LV LV NNP cord-023095-4dannjjm 6473 54 Long Long NNP cord-023095-4dannjjm 6473 55 - - HYPH cord-023095-4dannjjm 6473 56 axis axis NN cord-023095-4dannjjm 6473 57 dimension dimension NN cord-023095-4dannjjm 6473 58 and and CC cord-023095-4dannjjm 6473 59 RT3DE RT3DE NNP cord-023095-4dannjjm 6473 60 Sphericity Sphericity NNP cord-023095-4dannjjm 6473 61 index index NN cord-023095-4dannjjm 6473 62 , , , cord-023095-4dannjjm 6473 63 were be VBD cord-023095-4dannjjm 6473 64 derived derive VBN cord-023095-4dannjjm 6473 65 . . . cord-023095-4dannjjm 6474 1 Global global JJ cord-023095-4dannjjm 6474 2 and and CC cord-023095-4dannjjm 6474 3 regional regional JJ cord-023095-4dannjjm 6474 4 EDV EDV NNP cord-023095-4dannjjm 6474 5 and and CC cord-023095-4dannjjm 6474 6 ESV ESV NNP cord-023095-4dannjjm 6474 7 increased increase VBD cord-023095-4dannjjm 6474 8 significantly significantly RB cord-023095-4dannjjm 6474 9 with with IN cord-023095-4dannjjm 6474 10 increasing increase VBG cord-023095-4dannjjm 6474 11 MMVD MMVD NNP cord-023095-4dannjjm 6474 12 severity severity NN cord-023095-4dannjjm 6474 13 , , , cord-023095-4dannjjm 6474 14 assessed assess VBN cord-023095-4dannjjm 6474 15 by by IN cord-023095-4dannjjm 6474 16 MMVD MMVD NNP cord-023095-4dannjjm 6474 17 group group NN cord-023095-4dannjjm 6474 18 - - HYPH cord-023095-4dannjjm 6474 19 wise wise JJ cord-023095-4dannjjm 6474 20 comparisons comparison NNS cord-023095-4dannjjm 6474 21 and and CC cord-023095-4dannjjm 6474 22 linear linear JJ cord-023095-4dannjjm 6474 23 regression regression NN cord-023095-4dannjjm 6474 24 analyses analysis NNS cord-023095-4dannjjm 6474 25 using use VBG cord-023095-4dannjjm 6474 26 left leave VBN cord-023095-4dannjjm 6474 27 atrial atrial JJ cord-023095-4dannjjm 6474 28 to to IN cord-023095-4dannjjm 6474 29 aortic aortic JJ cord-023095-4dannjjm 6474 30 root root NN cord-023095-4dannjjm 6474 31 ratio ratio NN cord-023095-4dannjjm 6474 32 , , , cord-023095-4dannjjm 6474 33 and and CC cord-023095-4dannjjm 6474 34 LV LV NNP cord-023095-4dannjjm 6474 35 end end NN cord-023095-4dannjjm 6474 36 - - HYPH cord-023095-4dannjjm 6474 37 diastolic diastolic JJ cord-023095-4dannjjm 6474 38 and and CC cord-023095-4dannjjm 6474 39 end end NN cord-023095-4dannjjm 6474 40 - - HYPH cord-023095-4dannjjm 6474 41 systolic systolic JJ cord-023095-4dannjjm 6474 42 dimensions dimension NNS cord-023095-4dannjjm 6474 43 . . . cord-023095-4dannjjm 6475 1 All all DT cord-023095-4dannjjm 6475 2 three three CD cord-023095-4dannjjm 6475 3 segments segment NNS cord-023095-4dannjjm 6475 4 contributed contribute VBD cord-023095-4dannjjm 6475 5 to to IN cord-023095-4dannjjm 6475 6 the the DT cord-023095-4dannjjm 6475 7 overall overall JJ cord-023095-4dannjjm 6475 8 increased increase VBN cord-023095-4dannjjm 6475 9 global global JJ cord-023095-4dannjjm 6475 10 volumes volume NNS cord-023095-4dannjjm 6475 11 , , , cord-023095-4dannjjm 6475 12 but but CC cord-023095-4dannjjm 6475 13 the the DT cord-023095-4dannjjm 6475 14 mid mid JJ cord-023095-4dannjjm 6475 15 EDV EDV NNP cord-023095-4dannjjm 6475 16 segment segment NN cord-023095-4dannjjm 6475 17 was be VBD cord-023095-4dannjjm 6475 18 strongest strong JJS cord-023095-4dannjjm 6475 19 associated associate VBN cord-023095-4dannjjm 6475 20 with with IN cord-023095-4dannjjm 6475 21 increasing increase VBG cord-023095-4dannjjm 6475 22 LV LV NNP cord-023095-4dannjjm 6475 23 end end VB cord-023095-4dannjjm 6475 24 diastolic diastolic JJ cord-023095-4dannjjm 6475 25 dimension dimension NN cord-023095-4dannjjm 6475 26 ( ( -LRB- cord-023095-4dannjjm 6475 27 P p NN cord-023095-4dannjjm 6475 28 5 5 CD cord-023095-4dannjjm 6475 29 0.048 0.048 CD cord-023095-4dannjjm 6475 30 ) ) -RRB- cord-023095-4dannjjm 6475 31 . . . cord-023095-4dannjjm 6476 1 Furthermore furthermore RB cord-023095-4dannjjm 6476 2 , , , cord-023095-4dannjjm 6476 3 LV LV NNP cord-023095-4dannjjm 6476 4 Long Long NNP cord-023095-4dannjjm 6476 5 axis axis NN cord-023095-4dannjjm 6476 6 distance distance NN cord-023095-4dannjjm 6476 7 and and CC cord-023095-4dannjjm 6476 8 LV LV NNP cord-023095-4dannjjm 6476 9 Sphericity Sphericity NNP cord-023095-4dannjjm 6476 10 index index NN cord-023095-4dannjjm 6476 11 increased increase VBD cord-023095-4dannjjm 6476 12 with with IN cord-023095-4dannjjm 6476 13 increasing increase VBG cord-023095-4dannjjm 6476 14 MMVD MMVD NNP cord-023095-4dannjjm 6476 15 severity severity NN cord-023095-4dannjjm 6476 16 . . . cord-023095-4dannjjm 6477 1 The the DT cord-023095-4dannjjm 6477 2 basal basal NN cord-023095-4dannjjm 6477 3 and and CC cord-023095-4dannjjm 6477 4 apical apical JJ cord-023095-4dannjjm 6477 5 EDV EDV NNP cord-023095-4dannjjm 6477 6 segments segment NNS cord-023095-4dannjjm 6477 7 were be VBD cord-023095-4dannjjm 6477 8 strongest strongest RBS cord-023095-4dannjjm 6477 9 associated associate VBN cord-023095-4dannjjm 6477 10 with with IN cord-023095-4dannjjm 6477 11 Sphericity Sphericity NNP cord-023095-4dannjjm 6477 12 index index NN cord-023095-4dannjjm 6477 13 ( ( -LRB- cord-023095-4dannjjm 6477 14 P p NN cord-023095-4dannjjm 6477 15 o o NN cord-023095-4dannjjm 6477 16 0.0001 0.0001 CD cord-023095-4dannjjm 6477 17 ) ) -RRB- cord-023095-4dannjjm 6477 18 . . . cord-023095-4dannjjm 6478 1 In in IN cord-023095-4dannjjm 6478 2 conclusion conclusion NN cord-023095-4dannjjm 6478 3 , , , cord-023095-4dannjjm 6478 4 this this DT cord-023095-4dannjjm 6478 5 RT3DE RT3DE NNP cord-023095-4dannjjm 6478 6 study study NN cord-023095-4dannjjm 6478 7 showed show VBD cord-023095-4dannjjm 6478 8 that that IN cord-023095-4dannjjm 6478 9 increased increase VBD cord-023095-4dannjjm 6478 10 LV LV NNP cord-023095-4dannjjm 6478 11 EDV EDV NNP cord-023095-4dannjjm 6478 12 , , , cord-023095-4dannjjm 6478 13 primarily primarily RB cord-023095-4dannjjm 6478 14 in in IN cord-023095-4dannjjm 6478 15 the the DT cord-023095-4dannjjm 6478 16 mid mid JJ cord-023095-4dannjjm 6478 17 segment segment NN cord-023095-4dannjjm 6478 18 , , , cord-023095-4dannjjm 6478 19 leads lead VBZ cord-023095-4dannjjm 6478 20 to to IN cord-023095-4dannjjm 6478 21 rounding round VBG cord-023095-4dannjjm 6478 22 of of IN cord-023095-4dannjjm 6478 23 LV LV NNP cord-023095-4dannjjm 6478 24 apical apical JJ cord-023095-4dannjjm 6478 25 and and CC cord-023095-4dannjjm 6478 26 basal basal NN cord-023095-4dannjjm 6478 27 segments segment NNS cord-023095-4dannjjm 6478 28 in in IN cord-023095-4dannjjm 6478 29 response response NN cord-023095-4dannjjm 6478 30 to to IN cord-023095-4dannjjm 6478 31 increasing increase VBG cord-023095-4dannjjm 6478 32 MMVD MMVD NNP cord-023095-4dannjjm 6478 33 severity severity NN cord-023095-4dannjjm 6478 34 in in IN cord-023095-4dannjjm 6478 35 dogs dog NNS cord-023095-4dannjjm 6478 36 . . . cord-023095-4dannjjm 6479 1 84 84 CD cord-023095-4dannjjm 6479 2 dogs dog NNS cord-023095-4dannjjm 6479 3 from from IN cord-023095-4dannjjm 6479 4 shelters shelter NNS cord-023095-4dannjjm 6479 5 in in IN cord-023095-4dannjjm 6479 6 Florida Florida NNP cord-023095-4dannjjm 6479 7 with with IN cord-023095-4dannjjm 6479 8 naturally naturally RB cord-023095-4dannjjm 6479 9 acquired acquire VBN cord-023095-4dannjjm 6479 10 DI DI NNP cord-023095-4dannjjm 6479 11 infection infection NN cord-023095-4dannjjm 6479 12 were be VBD cord-023095-4dannjjm 6479 13 euthanized euthanize VBN cord-023095-4dannjjm 6479 14 and and CC cord-023095-4dannjjm 6479 15 necropsied necropsie VBN cord-023095-4dannjjm 6479 16 . . . cord-023095-4dannjjm 6480 1 All all DT cord-023095-4dannjjm 6480 2 adult adult NN cord-023095-4dannjjm 6480 3 DI DI NNP cord-023095-4dannjjm 6480 4 in in IN cord-023095-4dannjjm 6480 5 each each DT cord-023095-4dannjjm 6480 6 dog dog NN cord-023095-4dannjjm 6480 7 were be VBD cord-023095-4dannjjm 6480 8 sexed sex VBN cord-023095-4dannjjm 6480 9 using use VBG cord-023095-4dannjjm 6480 10 morphological morphological JJ cord-023095-4dannjjm 6480 11 features feature NNS cord-023095-4dannjjm 6480 12 . . . cord-023095-4dannjjm 6481 1 Total total JJ cord-023095-4dannjjm 6481 2 worm worm NN cord-023095-4dannjjm 6481 3 burdens burden NNS cord-023095-4dannjjm 6481 4 and and CC cord-023095-4dannjjm 6481 5 numbers number NNS cord-023095-4dannjjm 6481 6 of of IN cord-023095-4dannjjm 6481 7 males male NNS cord-023095-4dannjjm 6481 8 and and CC cord-023095-4dannjjm 6481 9 females female NNS cord-023095-4dannjjm 6481 10 were be VBD cord-023095-4dannjjm 6481 11 recorded record VBN cord-023095-4dannjjm 6481 12 . . . cord-023095-4dannjjm 6482 1 No no DT cord-023095-4dannjjm 6482 2 other other JJ cord-023095-4dannjjm 6482 3 information information NN cord-023095-4dannjjm 6482 4 was be VBD cord-023095-4dannjjm 6482 5 available available JJ cord-023095-4dannjjm 6482 6 for for IN cord-023095-4dannjjm 6482 7 any any DT cord-023095-4dannjjm 6482 8 dog dog NN cord-023095-4dannjjm 6482 9 . . . cord-023095-4dannjjm 6483 1 All all DT cord-023095-4dannjjm 6483 2 data datum NNS cord-023095-4dannjjm 6483 3 , , , cord-023095-4dannjjm 6483 4 raw raw JJ cord-023095-4dannjjm 6483 5 and and CC cord-023095-4dannjjm 6483 6 transformed transform VBN cord-023095-4dannjjm 6483 7 , , , cord-023095-4dannjjm 6483 8 were be VBD cord-023095-4dannjjm 6483 9 examined examine VBN cord-023095-4dannjjm 6483 10 visually visually RB cord-023095-4dannjjm 6483 11 and and CC cord-023095-4dannjjm 6483 12 descriptively descriptively RB cord-023095-4dannjjm 6483 13 . . . cord-023095-4dannjjm 6484 1 Raw raw JJ cord-023095-4dannjjm 6484 2 numerical numerical JJ cord-023095-4dannjjm 6484 3 data datum NNS cord-023095-4dannjjm 6484 4 were be VBD cord-023095-4dannjjm 6484 5 further further RB cord-023095-4dannjjm 6484 6 examined examine VBN cord-023095-4dannjjm 6484 7 by by IN cord-023095-4dannjjm 6484 8 a a DT cord-023095-4dannjjm 6484 9 paired pair VBN cord-023095-4dannjjm 6484 10 T t NN cord-023095-4dannjjm 6484 11 - - HYPH cord-023095-4dannjjm 6484 12 test test NN cord-023095-4dannjjm 6484 13 ; ; : cord-023095-4dannjjm 6484 14 log log NN cord-023095-4dannjjm 6484 15 - - HYPH cord-023095-4dannjjm 6484 16 odds odd NNS cord-023095-4dannjjm 6484 17 transformed transform VBN cord-023095-4dannjjm 6484 18 data datum NNS cord-023095-4dannjjm 6484 19 were be VBD cord-023095-4dannjjm 6484 20 examined examine VBN cord-023095-4dannjjm 6484 21 by by IN cord-023095-4dannjjm 6484 22 logistic logistic JJ cord-023095-4dannjjm 6484 23 regression regression NN cord-023095-4dannjjm 6484 24 . . . cord-023095-4dannjjm 6485 1 We -PRON- PRP cord-023095-4dannjjm 6485 2 also also RB cord-023095-4dannjjm 6485 3 conducted conduct VBD cord-023095-4dannjjm 6485 4 a a DT cord-023095-4dannjjm 6485 5 binomial binomial JJ cord-023095-4dannjjm 6485 6 distribution distribution NN cord-023095-4dannjjm 6485 7 goodness goodness NN cord-023095-4dannjjm 6485 8 of of IN cord-023095-4dannjjm 6485 9 fit fit JJ cord-023095-4dannjjm 6485 10 analysis analysis NN cord-023095-4dannjjm 6485 11 assuming assume VBG cord-023095-4dannjjm 6485 12 a a DT cord-023095-4dannjjm 6485 13 null null JJ cord-023095-4dannjjm 6485 14 hypothesis hypothesis NN cord-023095-4dannjjm 6485 15 of of IN cord-023095-4dannjjm 6485 16 a a DT cord-023095-4dannjjm 6485 17 M m NN cord-023095-4dannjjm 6485 18 : : : cord-023095-4dannjjm 6485 19 F F NNP cord-023095-4dannjjm 6485 20 5 5 CD cord-023095-4dannjjm 6485 21 1.0 1.0 CD cord-023095-4dannjjm 6485 22 . . . cord-023095-4dannjjm 6486 1 Worm worm NN cord-023095-4dannjjm 6486 2 intensities intensity NNS cord-023095-4dannjjm 6486 3 ranged range VBD cord-023095-4dannjjm 6486 4 from from IN cord-023095-4dannjjm 6486 5 1 1 CD cord-023095-4dannjjm 6486 6 to to IN cord-023095-4dannjjm 6486 7 143 143 CD cord-023095-4dannjjm 6486 8 DI di NN cord-023095-4dannjjm 6486 9 per per IN cord-023095-4dannjjm 6486 10 dog dog NN cord-023095-4dannjjm 6486 11 . . . cord-023095-4dannjjm 6487 1 Eight eight CD cord-023095-4dannjjm 6487 2 dogs dog NNS cord-023095-4dannjjm 6487 3 had have VBD cord-023095-4dannjjm 6487 4 unisex unisex JJ cord-023095-4dannjjm 6487 5 infections infection NNS cord-023095-4dannjjm 6487 6 : : : cord-023095-4dannjjm 6488 1 7/8 7/8 CD cord-023095-4dannjjm 6488 2 had have VBD cord-023095-4dannjjm 6488 3 all all DT cord-023095-4dannjjm 6488 4 - - HYPH cord-023095-4dannjjm 6488 5 female female JJ cord-023095-4dannjjm 6488 6 infections infection NNS cord-023095-4dannjjm 6488 7 . . . cord-023095-4dannjjm 6489 1 Dogs dog NNS cord-023095-4dannjjm 6489 2 with with IN cord-023095-4dannjjm 6489 3 lowintensity lowintensity NN cord-023095-4dannjjm 6489 4 dual dual JJ cord-023095-4dannjjm 6489 5 - - HYPH cord-023095-4dannjjm 6489 6 sex sex NN cord-023095-4dannjjm 6489 7 infections infection NNS cord-023095-4dannjjm 6489 8 were be VBD cord-023095-4dannjjm 6489 9 more more RBR cord-023095-4dannjjm 6489 10 likely likely JJ cord-023095-4dannjjm 6489 11 to to TO cord-023095-4dannjjm 6489 12 have have VB cord-023095-4dannjjm 6489 13 greater great JJR cord-023095-4dannjjm 6489 14 numbers number NNS cord-023095-4dannjjm 6489 15 of of IN cord-023095-4dannjjm 6489 16 female female JJ cord-023095-4dannjjm 6489 17 DI DI NNP cord-023095-4dannjjm 6489 18 . . . cord-023095-4dannjjm 6490 1 Overall overall RB cord-023095-4dannjjm 6490 2 , , , cord-023095-4dannjjm 6490 3 sex sex NN cord-023095-4dannjjm 6490 4 ratios ratio NNS cord-023095-4dannjjm 6490 5 were be VBD cord-023095-4dannjjm 6490 6 equal equal JJ cord-023095-4dannjjm 6490 7 ( ( -LRB- cord-023095-4dannjjm 6490 8 paired paired JJ cord-023095-4dannjjm 6490 9 t t NN cord-023095-4dannjjm 6490 10 - - HYPH cord-023095-4dannjjm 6490 11 test test NN cord-023095-4dannjjm 6490 12 , , , cord-023095-4dannjjm 6490 13 P p NN cord-023095-4dannjjm 6490 14 5 5 CD cord-023095-4dannjjm 6490 15 0.7 0.7 CD cord-023095-4dannjjm 6490 16 ) ) -RRB- cord-023095-4dannjjm 6490 17 . . . cord-023095-4dannjjm 6491 1 However however RB cord-023095-4dannjjm 6491 2 , , , cord-023095-4dannjjm 6491 3 logistic logistic JJ cord-023095-4dannjjm 6491 4 regression regression NN cord-023095-4dannjjm 6491 5 demonstrated demonstrate VBD cord-023095-4dannjjm 6491 6 that that IN cord-023095-4dannjjm 6491 7 the the DT cord-023095-4dannjjm 6491 8 probability probability NN cord-023095-4dannjjm 6491 9 of of IN cord-023095-4dannjjm 6491 10 being be VBG cord-023095-4dannjjm 6491 11 female female JJ cord-023095-4dannjjm 6491 12 is be VBZ cord-023095-4dannjjm 6491 13 strongly strongly RB cord-023095-4dannjjm 6491 14 affected affect VBN cord-023095-4dannjjm 6491 15 by by IN cord-023095-4dannjjm 6491 16 the the DT cord-023095-4dannjjm 6491 17 total total JJ cord-023095-4dannjjm 6491 18 worm worm NN cord-023095-4dannjjm 6491 19 intensity intensity NN cord-023095-4dannjjm 6491 20 , , , cord-023095-4dannjjm 6491 21 with with IN cord-023095-4dannjjm 6491 22 lower low JJR cord-023095-4dannjjm 6491 23 intensities intensity NNS cord-023095-4dannjjm 6491 24 increasing increase VBG cord-023095-4dannjjm 6491 25 the the DT cord-023095-4dannjjm 6491 26 probability probability NN cord-023095-4dannjjm 6491 27 of of IN cord-023095-4dannjjm 6491 28 having have VBG cord-023095-4dannjjm 6491 29 a a DT cord-023095-4dannjjm 6491 30 predominance predominance NN cord-023095-4dannjjm 6491 31 of of IN cord-023095-4dannjjm 6491 32 female female JJ cord-023095-4dannjjm 6491 33 worms worm NNS cord-023095-4dannjjm 6491 34 . . . cord-023095-4dannjjm 6492 1 Our -PRON- PRP$ cord-023095-4dannjjm 6492 2 data datum NNS cord-023095-4dannjjm 6492 3 show show VBP cord-023095-4dannjjm 6492 4 that that IN cord-023095-4dannjjm 6492 5 DI DI NNP cord-023095-4dannjjm 6492 6 sex sex NN cord-023095-4dannjjm 6492 7 ratios ratio NNS cord-023095-4dannjjm 6492 8 in in IN cord-023095-4dannjjm 6492 9 naturally naturally RB cord-023095-4dannjjm 6492 10 - - HYPH cord-023095-4dannjjm 6492 11 infected infect VBN cord-023095-4dannjjm 6492 12 dogs dog NNS cord-023095-4dannjjm 6492 13 equal equal VBP cord-023095-4dannjjm 6492 14 1 1 CD cord-023095-4dannjjm 6492 15 when when WRB cord-023095-4dannjjm 6492 16 examining examine VBG cord-023095-4dannjjm 6492 17 the the DT cord-023095-4dannjjm 6492 18 entire entire JJ cord-023095-4dannjjm 6492 19 dog dog NN cord-023095-4dannjjm 6492 20 population population NN cord-023095-4dannjjm 6492 21 , , , cord-023095-4dannjjm 6492 22 but but CC cord-023095-4dannjjm 6492 23 deviate deviate VB cord-023095-4dannjjm 6492 24 to to TO cord-023095-4dannjjm 6492 25 favor favor VB cord-023095-4dannjjm 6492 26 female female JJ cord-023095-4dannjjm 6492 27 worms worm NNS cord-023095-4dannjjm 6492 28 at at IN cord-023095-4dannjjm 6492 29 low low JJ cord-023095-4dannjjm 6492 30 worm worm NN cord-023095-4dannjjm 6492 31 intensities intensity NNS cord-023095-4dannjjm 6492 32 . . . cord-023095-4dannjjm 6493 1 These these DT cord-023095-4dannjjm 6493 2 data datum NNS cord-023095-4dannjjm 6493 3 could could MD cord-023095-4dannjjm 6493 4 impact impact VB cord-023095-4dannjjm 6493 5 adulticide adulticide NN cord-023095-4dannjjm 6493 6 treatment treatment NN cord-023095-4dannjjm 6493 7 strategies strategy NNS cord-023095-4dannjjm 6493 8 . . . cord-023095-4dannjjm 6494 1 The the DT cord-023095-4dannjjm 6494 2 reasons reason NNS cord-023095-4dannjjm 6494 3 for for IN cord-023095-4dannjjm 6494 4 sex sex NN cord-023095-4dannjjm 6494 5 ratio ratio NN cord-023095-4dannjjm 6494 6 distortion distortion NN cord-023095-4dannjjm 6494 7 in in IN cord-023095-4dannjjm 6494 8 DI DI NNP cord-023095-4dannjjm 6494 9 are be VBP cord-023095-4dannjjm 6494 10 unknown unknown JJ cord-023095-4dannjjm 6494 11 . . . cord-023095-4dannjjm 6495 1 We -PRON- PRP cord-023095-4dannjjm 6495 2 evaluated evaluate VBD cord-023095-4dannjjm 6495 3 cardiac cardiac JJ cord-023095-4dannjjm 6495 4 reverse reverse NN cord-023095-4dannjjm 6495 5 remodeling remodeling NN cord-023095-4dannjjm 6495 6 after after IN cord-023095-4dannjjm 6495 7 mitral mitral JJ cord-023095-4dannjjm 6495 8 valve valve NN cord-023095-4dannjjm 6495 9 repair repair NN cord-023095-4dannjjm 6495 10 under under IN cord-023095-4dannjjm 6495 11 cardiopulmonary cardiopulmonary JJ cord-023095-4dannjjm 6495 12 bypass bypass NN cord-023095-4dannjjm 6495 13 ( ( -LRB- cord-023095-4dannjjm 6495 14 CPB CPB NNP cord-023095-4dannjjm 6495 15 ) ) -RRB- cord-023095-4dannjjm 6495 16 for for IN cord-023095-4dannjjm 6495 17 mitral mitral JJ cord-023095-4dannjjm 6495 18 regurgitation regurgitation NN cord-023095-4dannjjm 6495 19 in in IN cord-023095-4dannjjm 6495 20 small small JJ cord-023095-4dannjjm 6495 21 breed breed NN cord-023095-4dannjjm 6495 22 dogs dog NNS cord-023095-4dannjjm 6495 23 . . . cord-023095-4dannjjm 6496 1 Fifty fifty CD cord-023095-4dannjjm 6496 2 dogs dog NNS cord-023095-4dannjjm 6496 3 ( ( -LRB- cord-023095-4dannjjm 6496 4 body body NN cord-023095-4dannjjm 6496 5 weight weight NN cord-023095-4dannjjm 6496 6 1.8 1.8 CD cord-023095-4dannjjm 6496 7 - - HYPH cord-023095-4dannjjm 6496 8 9.3 9.3 CD cord-023095-4dannjjm 6496 9 kg kg NN cord-023095-4dannjjm 6496 10 , , , cord-023095-4dannjjm 6496 11 age age NN cord-023095-4dannjjm 6496 12 5 5 CD cord-023095-4dannjjm 6496 13 - - SYM cord-023095-4dannjjm 6496 14 14 14 CD cord-023095-4dannjjm 6496 15 years year NNS cord-023095-4dannjjm 6496 16 ) ) -RRB- cord-023095-4dannjjm 6496 17 with with IN cord-023095-4dannjjm 6496 18 mitral mitral JJ cord-023095-4dannjjm 6496 19 regurgitation regurgitation NN cord-023095-4dannjjm 6496 20 were be VBD cord-023095-4dannjjm 6496 21 treated treat VBN cord-023095-4dannjjm 6496 22 between between IN cord-023095-4dannjjm 6496 23 August August NNP cord-023095-4dannjjm 6496 24 2006 2006 CD cord-023095-4dannjjm 6496 25 and and CC cord-023095-4dannjjm 6496 26 November November NNP cord-023095-4dannjjm 6496 27 2009 2009 CD cord-023095-4dannjjm 6496 28 . . . cord-023095-4dannjjm 6497 1 The the DT cord-023095-4dannjjm 6497 2 cardiac cardiac JJ cord-023095-4dannjjm 6497 3 murmur murmur NN cord-023095-4dannjjm 6497 4 was be VBD cord-023095-4dannjjm 6497 5 grade grade NN cord-023095-4dannjjm 6497 6 4/6 4/6 CD cord-023095-4dannjjm 6497 7 - - HYPH cord-023095-4dannjjm 6497 8 6/6 6/6 CD cord-023095-4dannjjm 6497 9 . . . cord-023095-4dannjjm 6498 1 The the DT cord-023095-4dannjjm 6498 2 preoperative preoperative JJ cord-023095-4dannjjm 6498 3 chest chest NN cord-023095-4dannjjm 6498 4 X X NNS cord-023095-4dannjjm 6498 5 - - NNS cord-023095-4dannjjm 6498 6 rays ray NNS cord-023095-4dannjjm 6498 7 showed show VBD cord-023095-4dannjjm 6498 8 cardiac cardiac JJ cord-023095-4dannjjm 6498 9 enlargement enlargement NN cord-023095-4dannjjm 6498 10 ( ( -LRB- cord-023095-4dannjjm 6498 11 vertebral vertebral JJ cord-023095-4dannjjm 6498 12 heart heart NN cord-023095-4dannjjm 6498 13 scale scale NN cord-023095-4dannjjm 6498 14 ( ( -LRB- cord-023095-4dannjjm 6498 15 VHS vhs NN cord-023095-4dannjjm 6498 16 ) ) -RRB- cord-023095-4dannjjm 6499 1 11.0 11.0 CD cord-023095-4dannjjm 6499 2 - - HYPH cord-023095-4dannjjm 6499 3 13.1 13.1 CD cord-023095-4dannjjm 6499 4 ) ) -RRB- cord-023095-4dannjjm 6499 5 . . . cord-023095-4dannjjm 6500 1 Echocardiography echocardiography NN cord-023095-4dannjjm 6500 2 showed show VBD cord-023095-4dannjjm 6500 3 severe severe JJ cord-023095-4dannjjm 6500 4 mitral mitral JJ cord-023095-4dannjjm 6500 5 regurgitation regurgitation NN cord-023095-4dannjjm 6500 6 and and CC cord-023095-4dannjjm 6500 7 left leave VBD cord-023095-4dannjjm 6500 8 atrium atrium NN cord-023095-4dannjjm 6500 9 enlargement enlargement NN cord-023095-4dannjjm 6500 10 ( ( -LRB- cord-023095-4dannjjm 6500 11 LA LA NNP cord-023095-4dannjjm 6500 12 / / SYM cord-023095-4dannjjm 6500 13 Ao Ao NNP cord-023095-4dannjjm 6500 14 2.0 2.0 NNP cord-023095-4dannjjm 6500 15 - - HYPH cord-023095-4dannjjm 6500 16 4.2 4.2 CD cord-023095-4dannjjm 6500 17 ) ) -RRB- cord-023095-4dannjjm 6500 18 . . . cord-023095-4dannjjm 6501 1 After after IN cord-023095-4dannjjm 6501 2 inducing induce VBG cord-023095-4dannjjm 6501 3 anesthesia anesthesia NN cord-023095-4dannjjm 6501 4 , , , cord-023095-4dannjjm 6501 5 a a DT cord-023095-4dannjjm 6501 6 thoracotomy thoracotomy NN cord-023095-4dannjjm 6501 7 was be VBD cord-023095-4dannjjm 6501 8 performed perform VBN cord-023095-4dannjjm 6501 9 in in IN cord-023095-4dannjjm 6501 10 the the DT cord-023095-4dannjjm 6501 11 fifth fifth JJ cord-023095-4dannjjm 6501 12 intercostal intercostal JJ cord-023095-4dannjjm 6501 13 space space NN cord-023095-4dannjjm 6501 14 . . . cord-023095-4dannjjm 6502 1 CPB CPB NNP cord-023095-4dannjjm 6502 2 was be VBD cord-023095-4dannjjm 6502 3 started start VBN cord-023095-4dannjjm 6502 4 by by IN cord-023095-4dannjjm 6502 5 using use VBG cord-023095-4dannjjm 6502 6 a a DT cord-023095-4dannjjm 6502 7 CPB CPB NNP cord-023095-4dannjjm 6502 8 circuit circuit NN cord-023095-4dannjjm 6502 9 connected connect VBN cord-023095-4dannjjm 6502 10 to to IN cord-023095-4dannjjm 6502 11 carotid carotid JJ cord-023095-4dannjjm 6502 12 artery artery NN cord-023095-4dannjjm 6502 13 and and CC cord-023095-4dannjjm 6502 14 jugular jugular NN cord-023095-4dannjjm 6502 15 vein vein NN cord-023095-4dannjjm 6502 16 catheters catheter NNS cord-023095-4dannjjm 6502 17 . . . cord-023095-4dannjjm 6503 1 After after IN cord-023095-4dannjjm 6503 2 inducing induce VBG cord-023095-4dannjjm 6503 3 cardiac cardiac JJ cord-023095-4dannjjm 6503 4 arrest arrest NN cord-023095-4dannjjm 6503 5 , , , cord-023095-4dannjjm 6503 6 the the DT cord-023095-4dannjjm 6503 7 left left JJ cord-023095-4dannjjm 6503 8 atrium atrium NN cord-023095-4dannjjm 6503 9 was be VBD cord-023095-4dannjjm 6503 10 sectioned section VBN cord-023095-4dannjjm 6503 11 and and CC cord-023095-4dannjjm 6503 12 chordae chordae NNP cord-023095-4dannjjm 6503 13 tendineae tendineae NNP cord-023095-4dannjjm 6503 14 rupture rupture NNP cord-023095-4dannjjm 6503 15 confirmed confirm VBD cord-023095-4dannjjm 6503 16 . . . cord-023095-4dannjjm 6504 1 The the DT cord-023095-4dannjjm 6504 2 chordae chordae NN cord-023095-4dannjjm 6504 3 tendineae tendineae NNS cord-023095-4dannjjm 6504 4 were be VBD cord-023095-4dannjjm 6504 5 replaced replace VBN cord-023095-4dannjjm 6504 6 with with IN cord-023095-4dannjjm 6504 7 expanded expand VBN cord-023095-4dannjjm 6504 8 polytetrafluoroethylene polytetrafluoroethylene NN cord-023095-4dannjjm 6504 9 . . . cord-023095-4dannjjm 6505 1 A a DT cord-023095-4dannjjm 6505 2 mitral mitral JJ cord-023095-4dannjjm 6505 3 annulus annulus NN cord-023095-4dannjjm 6505 4 plasty plasty NN cord-023095-4dannjjm 6505 5 was be VBD cord-023095-4dannjjm 6505 6 also also RB cord-023095-4dannjjm 6505 7 done do VBN cord-023095-4dannjjm 6505 8 , , , cord-023095-4dannjjm 6505 9 and and CC cord-023095-4dannjjm 6505 10 the the DT cord-023095-4dannjjm 6505 11 left left JJ cord-023095-4dannjjm 6505 12 atrium atrium NN cord-023095-4dannjjm 6505 13 was be VBD cord-023095-4dannjjm 6505 14 closed close VBN cord-023095-4dannjjm 6505 15 . . . cord-023095-4dannjjm 6506 1 After after IN cord-023095-4dannjjm 6506 2 de de NN cord-023095-4dannjjm 6506 3 - - NN cord-023095-4dannjjm 6506 4 clamping clamp VBG cord-023095-4dannjjm 6506 5 for for IN cord-023095-4dannjjm 6506 6 restarting restart VBG cord-023095-4dannjjm 6506 7 the the DT cord-023095-4dannjjm 6506 8 heart heart NN cord-023095-4dannjjm 6506 9 , , , cord-023095-4dannjjm 6506 10 the the DT cord-023095-4dannjjm 6506 11 chest chest NN cord-023095-4dannjjm 6506 12 was be VBD cord-023095-4dannjjm 6506 13 closed close VBN cord-023095-4dannjjm 6506 14 . . . cord-023095-4dannjjm 6507 1 Heart heart NN cord-023095-4dannjjm 6507 2 rate rate NN cord-023095-4dannjjm 6507 3 decreased decrease VBD cord-023095-4dannjjm 6507 4 from from IN cord-023095-4dannjjm 6507 5 118 118 CD cord-023095-4dannjjm 6507 6 - - SYM cord-023095-4dannjjm 6507 7 164 164 CD cord-023095-4dannjjm 6507 8 bpm bpm NN cord-023095-4dannjjm 6507 9 to to IN cord-023095-4dannjjm 6507 10 75 75 CD cord-023095-4dannjjm 6507 11 - - SYM cord-023095-4dannjjm 6507 12 138 138 CD cord-023095-4dannjjm 6507 13 bpm bpm NN cord-023095-4dannjjm 6507 14 . . . cord-023095-4dannjjm 6508 1 The the DT cord-023095-4dannjjm 6508 2 grade grade NN cord-023095-4dannjjm 6508 3 of of IN cord-023095-4dannjjm 6508 4 cardiac cardiac JJ cord-023095-4dannjjm 6508 5 murmur murmur NN cord-023095-4dannjjm 6508 6 was be VBD cord-023095-4dannjjm 6508 7 reduced reduce VBN cord-023095-4dannjjm 6508 8 to to IN cord-023095-4dannjjm 6508 9 0/6 0/6 CD cord-023095-4dannjjm 6508 10 - - CD cord-023095-4dannjjm 6508 11 3/6 3/6 CD cord-023095-4dannjjm 6508 12 three three CD cord-023095-4dannjjm 6508 13 months month NNS cord-023095-4dannjjm 6508 14 postoperatively postoperatively RB cord-023095-4dannjjm 6508 15 , , , cord-023095-4dannjjm 6508 16 and and CC cord-023095-4dannjjm 6508 17 the the DT cord-023095-4dannjjm 6508 18 heart heart NN cord-023095-4dannjjm 6508 19 shadow shadow NN cord-023095-4dannjjm 6508 20 was be VBD cord-023095-4dannjjm 6508 21 reduced reduce VBN cord-023095-4dannjjm 6508 22 ( ( -LRB- cord-023095-4dannjjm 6508 23 VHS VHS NNP cord-023095-4dannjjm 6508 24 9.8 9.8 CD cord-023095-4dannjjm 6508 25 - - HYPH cord-023095-4dannjjm 6508 26 11.5 11.5 CD cord-023095-4dannjjm 6508 27 ) ) -RRB- cord-023095-4dannjjm 6508 28 in in IN cord-023095-4dannjjm 6508 29 the the DT cord-023095-4dannjjm 6508 30 chest chest NN cord-023095-4dannjjm 6508 31 x x NNS cord-023095-4dannjjm 6508 32 - - NNS cord-023095-4dannjjm 6508 33 rays ray NNS cord-023095-4dannjjm 6508 34 . . . cord-023095-4dannjjm 6509 1 Echocardiography echocardiography NN cord-023095-4dannjjm 6509 2 confirmed confirm VBD cord-023095-4dannjjm 6509 3 the the DT cord-023095-4dannjjm 6509 4 marked marked JJ cord-023095-4dannjjm 6509 5 reduction reduction NN cord-023095-4dannjjm 6509 6 in in IN cord-023095-4dannjjm 6509 7 mitral mitral JJ cord-023095-4dannjjm 6509 8 regurgitation regurgitation NN cord-023095-4dannjjm 6509 9 and and CC cord-023095-4dannjjm 6509 10 the the DT cord-023095-4dannjjm 6509 11 left left JJ cord-023095-4dannjjm 6509 12 atrial atrial JJ cord-023095-4dannjjm 6509 13 dimensions dimension NNS cord-023095-4dannjjm 6509 14 ( ( -LRB- cord-023095-4dannjjm 6509 15 LA LA NNP cord-023095-4dannjjm 6509 16 / / SYM cord-023095-4dannjjm 6509 17 Ao Ao NNP cord-023095-4dannjjm 6509 18 1.2 1.2 CD cord-023095-4dannjjm 6509 19 - - SYM cord-023095-4dannjjm 6509 20 2.2 2.2 CD cord-023095-4dannjjm 6509 21 ) ) -RRB- cord-023095-4dannjjm 6509 22 . . . cord-023095-4dannjjm 6510 1 Mitral mitral JJ cord-023095-4dannjjm 6510 2 valve valve NN cord-023095-4dannjjm 6510 3 repair repair NN cord-023095-4dannjjm 6510 4 reduced reduce VBN cord-023095-4dannjjm 6510 5 enlarged enlarge VBD cord-023095-4dannjjm 6510 6 cardiac cardiac JJ cord-023095-4dannjjm 6510 7 size size NN cord-023095-4dannjjm 6510 8 by by IN cord-023095-4dannjjm 6510 9 reduction reduction NN cord-023095-4dannjjm 6510 10 of of IN cord-023095-4dannjjm 6510 11 regurgitant regurgitant JJ cord-023095-4dannjjm 6510 12 rate rate NN cord-023095-4dannjjm 6510 13 . . . cord-023095-4dannjjm 6511 1 Pulmonary pulmonary JJ cord-023095-4dannjjm 6511 2 arterial arterial JJ cord-023095-4dannjjm 6511 3 hypertension hypertension NN cord-023095-4dannjjm 6511 4 ( ( -LRB- cord-023095-4dannjjm 6511 5 PAH PAH NNP cord-023095-4dannjjm 6511 6 ) ) -RRB- cord-023095-4dannjjm 6511 7 is be VBZ cord-023095-4dannjjm 6511 8 a a DT cord-023095-4dannjjm 6511 9 well well RB cord-023095-4dannjjm 6511 10 recognized recognize VBN cord-023095-4dannjjm 6511 11 condition condition NN cord-023095-4dannjjm 6511 12 in in IN cord-023095-4dannjjm 6511 13 dogs dog NNS cord-023095-4dannjjm 6511 14 leading lead VBG cord-023095-4dannjjm 6511 15 to to IN cord-023095-4dannjjm 6511 16 considerable considerable JJ cord-023095-4dannjjm 6511 17 morbidity morbidity NN cord-023095-4dannjjm 6511 18 and and CC cord-023095-4dannjjm 6511 19 mortality mortality NN cord-023095-4dannjjm 6511 20 . . . cord-023095-4dannjjm 6512 1 The the DT cord-023095-4dannjjm 6512 2 majority majority NN cord-023095-4dannjjm 6512 3 of of IN cord-023095-4dannjjm 6512 4 therapeutics therapeutic NNS cord-023095-4dannjjm 6512 5 has have VBZ cord-023095-4dannjjm 6512 6 focused focus VBN cord-023095-4dannjjm 6512 7 on on IN cord-023095-4dannjjm 6512 8 endothelial endothelial JJ cord-023095-4dannjjm 6512 9 dysfunction dysfunction NN cord-023095-4dannjjm 6512 10 causing cause VBG cord-023095-4dannjjm 6512 11 reduced reduce VBN cord-023095-4dannjjm 6512 12 production production NN cord-023095-4dannjjm 6512 13 of of IN cord-023095-4dannjjm 6512 14 vasodilators vasodilator NNS cord-023095-4dannjjm 6512 15 , , , cord-023095-4dannjjm 6512 16 such such JJ cord-023095-4dannjjm 6512 17 as as IN cord-023095-4dannjjm 6512 18 nitric nitric JJ cord-023095-4dannjjm 6512 19 oxide oxide NN cord-023095-4dannjjm 6512 20 and and CC cord-023095-4dannjjm 6512 21 prostacyclin prostacyclin NN cord-023095-4dannjjm 6512 22 , , , cord-023095-4dannjjm 6512 23 coupled couple VBN cord-023095-4dannjjm 6512 24 with with IN cord-023095-4dannjjm 6512 25 overproduction overproduction NN cord-023095-4dannjjm 6512 26 of of IN cord-023095-4dannjjm 6512 27 vasoconstrictors vasoconstrictor NNS cord-023095-4dannjjm 6512 28 , , , cord-023095-4dannjjm 6512 29 such such JJ cord-023095-4dannjjm 6512 30 as as IN cord-023095-4dannjjm 6512 31 endothelin-1 endothelin-1 NNP cord-023095-4dannjjm 6512 32 . . . cord-023095-4dannjjm 6513 1 More more RBR cord-023095-4dannjjm 6513 2 recently recently RB cord-023095-4dannjjm 6513 3 , , , cord-023095-4dannjjm 6513 4 it -PRON- PRP cord-023095-4dannjjm 6513 5 has have VBZ cord-023095-4dannjjm 6513 6 been be VBN cord-023095-4dannjjm 6513 7 shown show VBN cord-023095-4dannjjm 6513 8 that that IN cord-023095-4dannjjm 6513 9 the the DT cord-023095-4dannjjm 6513 10 mitochondria mitochondrion NNS cord-023095-4dannjjm 6513 11 play play VBP cord-023095-4dannjjm 6513 12 an an DT cord-023095-4dannjjm 6513 13 important important JJ cord-023095-4dannjjm 6513 14 role role NN cord-023095-4dannjjm 6513 15 in in IN cord-023095-4dannjjm 6513 16 the the DT cord-023095-4dannjjm 6513 17 development development NN cord-023095-4dannjjm 6513 18 of of IN cord-023095-4dannjjm 6513 19 PAH PAH NNP cord-023095-4dannjjm 6513 20 as as IN cord-023095-4dannjjm 6513 21 oxygen oxygen NN cord-023095-4dannjjm 6513 22 sensors sensor NNS cord-023095-4dannjjm 6513 23 and and CC cord-023095-4dannjjm 6513 24 regulators regulator NNS cord-023095-4dannjjm 6513 25 of of IN cord-023095-4dannjjm 6513 26 cellular cellular JJ cord-023095-4dannjjm 6513 27 proliferation proliferation NN cord-023095-4dannjjm 6513 28 . . . cord-023095-4dannjjm 6514 1 In in IN cord-023095-4dannjjm 6514 2 PAH PAH NNP cord-023095-4dannjjm 6514 3 , , , cord-023095-4dannjjm 6514 4 pulmonary pulmonary JJ cord-023095-4dannjjm 6514 5 artery artery NN cord-023095-4dannjjm 6514 6 smooth smooth JJ cord-023095-4dannjjm 6514 7 muscle muscle NN cord-023095-4dannjjm 6514 8 cells cell NNS cord-023095-4dannjjm 6514 9 undergo undergo VBP cord-023095-4dannjjm 6514 10 a a DT cord-023095-4dannjjm 6514 11 metabolic metabolic JJ cord-023095-4dannjjm 6514 12 shift shift NN cord-023095-4dannjjm 6514 13 from from IN cord-023095-4dannjjm 6514 14 oxidative oxidative JJ cord-023095-4dannjjm 6514 15 phosphorylation phosphorylation NN cord-023095-4dannjjm 6514 16 in in IN cord-023095-4dannjjm 6514 17 the the DT cord-023095-4dannjjm 6514 18 mitochondria mitochondrion NNS cord-023095-4dannjjm 6514 19 to to IN cord-023095-4dannjjm 6514 20 glycolysis glycolysis NN cord-023095-4dannjjm 6514 21 in in IN cord-023095-4dannjjm 6514 22 the the DT cord-023095-4dannjjm 6514 23 cytoplasm cytoplasm NN cord-023095-4dannjjm 6514 24 as as IN cord-023095-4dannjjm 6514 25 the the DT cord-023095-4dannjjm 6514 26 major major JJ cord-023095-4dannjjm 6514 27 energy energy NN cord-023095-4dannjjm 6514 28 source source NN cord-023095-4dannjjm 6514 29 and and CC cord-023095-4dannjjm 6514 30 this this DT cord-023095-4dannjjm 6514 31 leads lead VBZ cord-023095-4dannjjm 6514 32 to to IN cord-023095-4dannjjm 6514 33 suppression suppression NN cord-023095-4dannjjm 6514 34 of of IN cord-023095-4dannjjm 6514 35 apoptosis apoptosis NN cord-023095-4dannjjm 6514 36 and and CC cord-023095-4dannjjm 6514 37 increased increase VBN cord-023095-4dannjjm 6514 38 proliferation proliferation NN cord-023095-4dannjjm 6514 39 . . . cord-023095-4dannjjm 6515 1 Dichloroacetate Dichloroacetate NNP cord-023095-4dannjjm 6515 2 ( ( -LRB- cord-023095-4dannjjm 6515 3 DCA DCA NNP cord-023095-4dannjjm 6515 4 ) ) -RRB- cord-023095-4dannjjm 6515 5 inhibits inhibit VBZ cord-023095-4dannjjm 6515 6 pyruvate pyruvate NN cord-023095-4dannjjm 6515 7 dehydrogenase dehydrogenase NN cord-023095-4dannjjm 6515 8 kinase kinase NN cord-023095-4dannjjm 6515 9 to to TO cord-023095-4dannjjm 6515 10 activate activate VB cord-023095-4dannjjm 6515 11 pyruvate pyruvate NN cord-023095-4dannjjm 6515 12 dehydrogenase dehydrogenase NN cord-023095-4dannjjm 6515 13 which which WDT cord-023095-4dannjjm 6515 14 catalyzes catalyze VBZ cord-023095-4dannjjm 6515 15 the the DT cord-023095-4dannjjm 6515 16 rate rate NN cord-023095-4dannjjm 6515 17 limiting limit VBG cord-023095-4dannjjm 6515 18 step step NN cord-023095-4dannjjm 6515 19 for for IN cord-023095-4dannjjm 6515 20 entry entry NN cord-023095-4dannjjm 6515 21 of of IN cord-023095-4dannjjm 6515 22 pyruvate pyruvate NN cord-023095-4dannjjm 6515 23 into into IN cord-023095-4dannjjm 6515 24 the the DT cord-023095-4dannjjm 6515 25 Krebs Krebs NNP cord-023095-4dannjjm 6515 26 cycle cycle NN cord-023095-4dannjjm 6515 27 , , , cord-023095-4dannjjm 6515 28 thus thus RB cord-023095-4dannjjm 6515 29 increasing increase VBG cord-023095-4dannjjm 6515 30 mitochondrial mitochondrial JJ cord-023095-4dannjjm 6515 31 respiration respiration NN cord-023095-4dannjjm 6515 32 . . . cord-023095-4dannjjm 6516 1 In in IN cord-023095-4dannjjm 6516 2 three three CD cord-023095-4dannjjm 6516 3 different different JJ cord-023095-4dannjjm 6516 4 rat rat NN cord-023095-4dannjjm 6516 5 models model NNS cord-023095-4dannjjm 6516 6 of of IN cord-023095-4dannjjm 6516 7 PAH PAH NNP cord-023095-4dannjjm 6516 8 , , , cord-023095-4dannjjm 6516 9 DCA DCA NNP cord-023095-4dannjjm 6516 10 has have VBZ cord-023095-4dannjjm 6516 11 been be VBN cord-023095-4dannjjm 6516 12 shown show VBN cord-023095-4dannjjm 6516 13 prevent prevent VB cord-023095-4dannjjm 6516 14 and and CC cord-023095-4dannjjm 6516 15 reverse reverse VB cord-023095-4dannjjm 6516 16 PAH PAH NNP cord-023095-4dannjjm 6516 17 by by IN cord-023095-4dannjjm 6516 18 normalizing normalize VBG cord-023095-4dannjjm 6516 19 molecular molecular JJ cord-023095-4dannjjm 6516 20 pathology pathology NN cord-023095-4dannjjm 6516 21 , , , cord-023095-4dannjjm 6516 22 stimulating stimulate VBG cord-023095-4dannjjm 6516 23 apoptosis apoptosis NN cord-023095-4dannjjm 6516 24 of of IN cord-023095-4dannjjm 6516 25 pulmonary pulmonary JJ cord-023095-4dannjjm 6516 26 artery artery NN cord-023095-4dannjjm 6516 27 smooth smooth JJ cord-023095-4dannjjm 6516 28 muscle muscle NN cord-023095-4dannjjm 6516 29 cells cell NNS cord-023095-4dannjjm 6516 30 , , , cord-023095-4dannjjm 6516 31 and and CC cord-023095-4dannjjm 6516 32 reducing reduce VBG cord-023095-4dannjjm 6516 33 pulmonary pulmonary JJ cord-023095-4dannjjm 6516 34 artery artery NN cord-023095-4dannjjm 6516 35 hypertrophy hypertrophy NN cord-023095-4dannjjm 6516 36 . . . cord-023095-4dannjjm 6517 1 DCA DCA NNP cord-023095-4dannjjm 6517 2 has have VBZ cord-023095-4dannjjm 6517 3 known know VBN cord-023095-4dannjjm 6517 4 toxic toxic JJ cord-023095-4dannjjm 6517 5 effects effect NNS cord-023095-4dannjjm 6517 6 , , , cord-023095-4dannjjm 6517 7 including include VBG cord-023095-4dannjjm 6517 8 reversible reversible JJ cord-023095-4dannjjm 6517 9 hepatotoxicity hepatotoxicity NN cord-023095-4dannjjm 6517 10 and and CC cord-023095-4dannjjm 6517 11 peripheral peripheral JJ cord-023095-4dannjjm 6517 12 neuropathy neuropathy NN cord-023095-4dannjjm 6517 13 , , , cord-023095-4dannjjm 6517 14 and and CC cord-023095-4dannjjm 6517 15 has have VBZ cord-023095-4dannjjm 6517 16 not not RB cord-023095-4dannjjm 6517 17 been be VBN cord-023095-4dannjjm 6517 18 studied study VBN cord-023095-4dannjjm 6517 19 in in IN cord-023095-4dannjjm 6517 20 any any DT cord-023095-4dannjjm 6517 21 species specie NNS cord-023095-4dannjjm 6517 22 with with IN cord-023095-4dannjjm 6517 23 naturally naturally RB cord-023095-4dannjjm 6517 24 occurring occur VBG cord-023095-4dannjjm 6517 25 PAH PAH NNP cord-023095-4dannjjm 6517 26 . . . cord-023095-4dannjjm 6518 1 The the DT cord-023095-4dannjjm 6518 2 objective objective NN cord-023095-4dannjjm 6518 3 of of IN cord-023095-4dannjjm 6518 4 this this DT cord-023095-4dannjjm 6518 5 open open JJ cord-023095-4dannjjm 6518 6 label label NN cord-023095-4dannjjm 6518 7 pilot pilot NN cord-023095-4dannjjm 6518 8 study study NN cord-023095-4dannjjm 6518 9 is be VBZ cord-023095-4dannjjm 6518 10 to to TO cord-023095-4dannjjm 6518 11 evaluate evaluate VB cord-023095-4dannjjm 6518 12 the the DT cord-023095-4dannjjm 6518 13 therapeutic therapeutic JJ cord-023095-4dannjjm 6518 14 and and CC cord-023095-4dannjjm 6518 15 toxic toxic JJ cord-023095-4dannjjm 6518 16 effects effect NNS cord-023095-4dannjjm 6518 17 of of IN cord-023095-4dannjjm 6518 18 DCA DCA NNP cord-023095-4dannjjm 6518 19 in in IN cord-023095-4dannjjm 6518 20 naturally naturally RB cord-023095-4dannjjm 6518 21 occurring occur VBG cord-023095-4dannjjm 6518 22 canine canine JJ cord-023095-4dannjjm 6518 23 PAH PAH NNP cord-023095-4dannjjm 6518 24 . . . cord-023095-4dannjjm 6519 1 Three three CD cord-023095-4dannjjm 6519 2 dogs dog NNS cord-023095-4dannjjm 6519 3 with with IN cord-023095-4dannjjm 6519 4 PAH PAH NNP cord-023095-4dannjjm 6519 5 diagnosed diagnose VBN cord-023095-4dannjjm 6519 6 by by IN cord-023095-4dannjjm 6519 7 Doppler Doppler NNP cord-023095-4dannjjm 6519 8 echocardiography echocardiography NN cord-023095-4dannjjm 6519 9 and and CC cord-023095-4dannjjm 6519 10 no no DT cord-023095-4dannjjm 6519 11 correctable correctable JJ cord-023095-4dannjjm 6519 12 underlying underlying JJ cord-023095-4dannjjm 6519 13 cause cause NN cord-023095-4dannjjm 6519 14 are be VBP cord-023095-4dannjjm 6519 15 enrolled enrol VBN cord-023095-4dannjjm 6519 16 in in IN cord-023095-4dannjjm 6519 17 the the DT cord-023095-4dannjjm 6519 18 study study NN cord-023095-4dannjjm 6519 19 . . . cord-023095-4dannjjm 6520 1 Dogs dog NNS cord-023095-4dannjjm 6520 2 are be VBP cord-023095-4dannjjm 6520 3 orally orally RB cord-023095-4dannjjm 6520 4 administered administer VBN cord-023095-4dannjjm 6520 5 25 25 CD cord-023095-4dannjjm 6520 6 mg mg NNP cord-023095-4dannjjm 6520 7 / / SYM cord-023095-4dannjjm 6520 8 kg kg NNP cord-023095-4dannjjm 6520 9 of of IN cord-023095-4dannjjm 6520 10 DCA DCA NNP cord-023095-4dannjjm 6520 11 divided divide VBD cord-023095-4dannjjm 6520 12 daily daily RB cord-023095-4dannjjm 6520 13 for for IN cord-023095-4dannjjm 6520 14 2 2 CD cord-023095-4dannjjm 6520 15 weeks week NNS cord-023095-4dannjjm 6520 16 , , , cord-023095-4dannjjm 6520 17 and and CC cord-023095-4dannjjm 6520 18 then then RB cord-023095-4dannjjm 6520 19 12.5 12.5 CD cord-023095-4dannjjm 6520 20 mg mg NNP cord-023095-4dannjjm 6520 21 / / SYM cord-023095-4dannjjm 6520 22 kg kg NNP cord-023095-4dannjjm 6520 23 of of IN cord-023095-4dannjjm 6520 24 DCA DCA NNP cord-023095-4dannjjm 6520 25 divided divide VBD cord-023095-4dannjjm 6520 26 daily daily RB cord-023095-4dannjjm 6520 27 for for IN cord-023095-4dannjjm 6520 28 the the DT cord-023095-4dannjjm 6520 29 remainder remainder NN cord-023095-4dannjjm 6520 30 of of IN cord-023095-4dannjjm 6520 31 the the DT cord-023095-4dannjjm 6520 32 study study NN cord-023095-4dannjjm 6520 33 . . . cord-023095-4dannjjm 6521 1 At at IN cord-023095-4dannjjm 6521 2 baseline baseline NN cord-023095-4dannjjm 6521 3 , , , cord-023095-4dannjjm 6521 4 2 2 CD cord-023095-4dannjjm 6521 5 , , , cord-023095-4dannjjm 6521 6 4 4 CD cord-023095-4dannjjm 6521 7 , , , cord-023095-4dannjjm 6521 8 8 8 CD cord-023095-4dannjjm 6521 9 , , , cord-023095-4dannjjm 6521 10 and and CC cord-023095-4dannjjm 6521 11 12 12 CD cord-023095-4dannjjm 6521 12 weeks week NNS cord-023095-4dannjjm 6521 13 , , , cord-023095-4dannjjm 6521 14 an an DT cord-023095-4dannjjm 6521 15 echocardiogram echocardiogram NN cord-023095-4dannjjm 6521 16 , , , cord-023095-4dannjjm 6521 17 CBC CBC NNP cord-023095-4dannjjm 6521 18 , , , cord-023095-4dannjjm 6521 19 serum serum NN cord-023095-4dannjjm 6521 20 chemistry chemistry NN cord-023095-4dannjjm 6521 21 profile profile NN cord-023095-4dannjjm 6521 22 , , , cord-023095-4dannjjm 6521 23 urinalysis urinalysis NN cord-023095-4dannjjm 6521 24 , , , cord-023095-4dannjjm 6521 25 NT NT NNP cord-023095-4dannjjm 6521 26 - - HYPH cord-023095-4dannjjm 6521 27 proBNP probnp NN cord-023095-4dannjjm 6521 28 , , , cord-023095-4dannjjm 6521 29 blood blood NN cord-023095-4dannjjm 6521 30 uric uric NN cord-023095-4dannjjm 6521 31 acid acid NN cord-023095-4dannjjm 6521 32 , , , cord-023095-4dannjjm 6521 33 blood blood NN cord-023095-4dannjjm 6521 34 lactate lactate NN cord-023095-4dannjjm 6521 35 , , , cord-023095-4dannjjm 6521 36 noninvasive noninvasive JJ cord-023095-4dannjjm 6521 37 blood blood NN cord-023095-4dannjjm 6521 38 pressure pressure NN cord-023095-4dannjjm 6521 39 , , , cord-023095-4dannjjm 6521 40 nerve nerve NN cord-023095-4dannjjm 6521 41 conduction conduction NN cord-023095-4dannjjm 6521 42 study study NN cord-023095-4dannjjm 6521 43 , , , cord-023095-4dannjjm 6521 44 and and CC cord-023095-4dannjjm 6521 45 trough trough NN cord-023095-4dannjjm 6521 46 DCA DCA NNP cord-023095-4dannjjm 6521 47 level level NN cord-023095-4dannjjm 6521 48 ( ( -LRB- cord-023095-4dannjjm 6521 49 12 12 CD cord-023095-4dannjjm 6521 50 hr hr NN cord-023095-4dannjjm 6521 51 post post NN cord-023095-4dannjjm 6521 52 - - JJ cord-023095-4dannjjm 6521 53 dose dose JJ cord-023095-4dannjjm 6521 54 ) ) -RRB- cord-023095-4dannjjm 6521 55 are be VBP cord-023095-4dannjjm 6521 56 obtained obtain VBN cord-023095-4dannjjm 6521 57 . . . cord-023095-4dannjjm 6522 1 The the DT cord-023095-4dannjjm 6522 2 measured measure VBN cord-023095-4dannjjm 6522 3 echocardiographic echocardiographic JJ cord-023095-4dannjjm 6522 4 parameters parameter NNS cord-023095-4dannjjm 6522 5 include include VBP cord-023095-4dannjjm 6522 6 peak peak NN cord-023095-4dannjjm 6522 7 and and CC cord-023095-4dannjjm 6522 8 mean mean JJ cord-023095-4dannjjm 6522 9 tricuspid tricuspid NNP cord-023095-4dannjjm 6522 10 regurgitant regurgitant JJ cord-023095-4dannjjm 6522 11 flow flow NN cord-023095-4dannjjm 6522 12 velocity velocity NN cord-023095-4dannjjm 6522 13 and and CC cord-023095-4dannjjm 6522 14 pressure pressure NN cord-023095-4dannjjm 6522 15 gradient gradient NN cord-023095-4dannjjm 6522 16 , , , cord-023095-4dannjjm 6522 17 peak peak NN cord-023095-4dannjjm 6522 18 and and CC cord-023095-4dannjjm 6522 19 enddiastolic enddiastolic JJ cord-023095-4dannjjm 6522 20 pulmonary pulmonary JJ cord-023095-4dannjjm 6522 21 regurgitant regurgitant NN cord-023095-4dannjjm 6522 22 flow flow NN cord-023095-4dannjjm 6522 23 velocity velocity NN cord-023095-4dannjjm 6522 24 and and CC cord-023095-4dannjjm 6522 25 pressure pressure NN cord-023095-4dannjjm 6522 26 gradient gradient NN cord-023095-4dannjjm 6522 27 , , , cord-023095-4dannjjm 6522 28 pulmonary pulmonary JJ cord-023095-4dannjjm 6522 29 valve valve NN cord-023095-4dannjjm 6522 30 flow flow NN cord-023095-4dannjjm 6522 31 velocity velocity NN cord-023095-4dannjjm 6522 32 acceleration acceleration NN cord-023095-4dannjjm 6522 33 time time NN cord-023095-4dannjjm 6522 34 and and CC cord-023095-4dannjjm 6522 35 ejection ejection NN cord-023095-4dannjjm 6522 36 time time NN cord-023095-4dannjjm 6522 37 , , , cord-023095-4dannjjm 6522 38 pulmonary pulmonary JJ cord-023095-4dannjjm 6522 39 valve valve NN cord-023095-4dannjjm 6522 40 flow flow NN cord-023095-4dannjjm 6522 41 velocity velocity NN cord-023095-4dannjjm 6522 42 time time NN cord-023095-4dannjjm 6522 43 integral integral JJ cord-023095-4dannjjm 6522 44 , , , cord-023095-4dannjjm 6522 45 right right JJ cord-023095-4dannjjm 6522 46 ventricular ventricular JJ cord-023095-4dannjjm 6522 47 myocardial myocardial JJ cord-023095-4dannjjm 6522 48 performance performance NN cord-023095-4dannjjm 6522 49 index index NN cord-023095-4dannjjm 6522 50 , , , cord-023095-4dannjjm 6522 51 tricuspid tricuspid JJ cord-023095-4dannjjm 6522 52 annular annular JJ cord-023095-4dannjjm 6522 53 plane plane NN cord-023095-4dannjjm 6522 54 systolic systolic JJ cord-023095-4dannjjm 6522 55 excursion excursion NN cord-023095-4dannjjm 6522 56 , , , cord-023095-4dannjjm 6522 57 and and CC cord-023095-4dannjjm 6522 58 systolic systolic JJ cord-023095-4dannjjm 6522 59 tricuspid tricuspid JJ cord-023095-4dannjjm 6522 60 annular annular JJ cord-023095-4dannjjm 6522 61 tissue tissue NN cord-023095-4dannjjm 6522 62 velocity velocity NN cord-023095-4dannjjm 6522 63 . . . cord-023095-4dannjjm 6523 1 Variables variable NNS cord-023095-4dannjjm 6523 2 are be VBP cord-023095-4dannjjm 6523 3 inspected inspect VBN cord-023095-4dannjjm 6523 4 for for IN cord-023095-4dannjjm 6523 5 normalcy normalcy NN cord-023095-4dannjjm 6523 6 and and CC cord-023095-4dannjjm 6523 7 equality equality NN cord-023095-4dannjjm 6523 8 of of IN cord-023095-4dannjjm 6523 9 variances variance NNS cord-023095-4dannjjm 6523 10 and and CC cord-023095-4dannjjm 6523 11 a a DT cord-023095-4dannjjm 6523 12 two two CD cord-023095-4dannjjm 6523 13 - - HYPH cord-023095-4dannjjm 6523 14 sided sided JJ cord-023095-4dannjjm 6523 15 paired pair VBN cord-023095-4dannjjm 6523 16 t t NN cord-023095-4dannjjm 6523 17 - - HYPH cord-023095-4dannjjm 6523 18 test test NN cord-023095-4dannjjm 6523 19 is be VBZ cord-023095-4dannjjm 6523 20 used use VBN cord-023095-4dannjjm 6523 21 to to TO cord-023095-4dannjjm 6523 22 compare compare VB cord-023095-4dannjjm 6523 23 the the DT cord-023095-4dannjjm 6523 24 variables variable NNS cord-023095-4dannjjm 6523 25 before before IN cord-023095-4dannjjm 6523 26 and and CC cord-023095-4dannjjm 6523 27 after after IN cord-023095-4dannjjm 6523 28 treatment treatment NN cord-023095-4dannjjm 6523 29 at at IN cord-023095-4dannjjm 6523 30 each each DT cord-023095-4dannjjm 6523 31 evaluation evaluation NN cord-023095-4dannjjm 6523 32 time time NN cord-023095-4dannjjm 6523 33 . . . cord-023095-4dannjjm 6524 1 The the DT cord-023095-4dannjjm 6524 2 basis basis NN cord-023095-4dannjjm 6524 3 for for IN cord-023095-4dannjjm 6524 4 the the DT cord-023095-4dannjjm 6524 5 role role NN cord-023095-4dannjjm 6524 6 of of IN cord-023095-4dannjjm 6524 7 the the DT cord-023095-4dannjjm 6524 8 mitochondria mitochondrion NNS cord-023095-4dannjjm 6524 9 in in IN cord-023095-4dannjjm 6524 10 PAH PAH NNP cord-023095-4dannjjm 6524 11 and and CC cord-023095-4dannjjm 6524 12 the the DT cord-023095-4dannjjm 6524 13 results result NNS cord-023095-4dannjjm 6524 14 of of IN cord-023095-4dannjjm 6524 15 this this DT cord-023095-4dannjjm 6524 16 pilot pilot NN cord-023095-4dannjjm 6524 17 study study NN cord-023095-4dannjjm 6524 18 will will MD cord-023095-4dannjjm 6524 19 be be VB cord-023095-4dannjjm 6524 20 presented present VBN cord-023095-4dannjjm 6524 21 to to TO cord-023095-4dannjjm 6524 22 determine determine VB cord-023095-4dannjjm 6524 23 if if IN cord-023095-4dannjjm 6524 24 DCA DCA NNP cord-023095-4dannjjm 6524 25 warrants warrant NNS cord-023095-4dannjjm 6524 26 further further JJ cord-023095-4dannjjm 6524 27 study study NN cord-023095-4dannjjm 6524 28 as as IN cord-023095-4dannjjm 6524 29 a a DT cord-023095-4dannjjm 6524 30 therapy therapy NN cord-023095-4dannjjm 6524 31 for for IN cord-023095-4dannjjm 6524 32 dogs dog NNS cord-023095-4dannjjm 6524 33 with with IN cord-023095-4dannjjm 6524 34 PAH PAH NNP cord-023095-4dannjjm 6524 35 . . . cord-023095-4dannjjm 6525 1 study study NN cord-023095-4dannjjm 6525 2 produced produce VBD cord-023095-4dannjjm 6525 3 the the DT cord-023095-4dannjjm 6525 4 strongest strong JJS cord-023095-4dannjjm 6525 5 associations association NNS cord-023095-4dannjjm 6525 6 between between IN cord-023095-4dannjjm 6525 7 the the DT cord-023095-4dannjjm 6525 8 NCL NCL NNP cord-023095-4dannjjm 6525 9 phenotype phenotype NN cord-023095-4dannjjm 6525 10 and and CC cord-023095-4dannjjm 6525 11 CFA2 cfa2 JJ cord-023095-4dannjjm 6525 12 markers marker NNS cord-023095-4dannjjm 6525 13 . . . cord-023095-4dannjjm 6526 1 All all DT cord-023095-4dannjjm 6526 2 19 19 CD cord-023095-4dannjjm 6526 3 NCL NCL NNP cord-023095-4dannjjm 6526 4 - - HYPH cord-023095-4dannjjm 6526 5 affected affect VBN cord-023095-4dannjjm 6526 6 Tibetan Tibetan NNP cord-023095-4dannjjm 6526 7 Terriers Terriers NNPS cord-023095-4dannjjm 6526 8 were be VBD cord-023095-4dannjjm 6526 9 homozygous homozygous JJ cord-023095-4dannjjm 6526 10 for for IN cord-023095-4dannjjm 6526 11 the the DT cord-023095-4dannjjm 6526 12 same same JJ cord-023095-4dannjjm 6526 13 haplotype haplotype NN cord-023095-4dannjjm 6526 14 which which WDT cord-023095-4dannjjm 6526 15 extended extend VBD cord-023095-4dannjjm 6526 16 for for IN cord-023095-4dannjjm 6526 17 22 22 CD cord-023095-4dannjjm 6526 18 consecutive consecutive JJ cord-023095-4dannjjm 6526 19 SNPs snp NNS cord-023095-4dannjjm 6526 20 spanning span VBG cord-023095-4dannjjm 6526 21 0.95 0.95 CD cord-023095-4dannjjm 6526 22 Mb Mb NNS cord-023095-4dannjjm 6526 23 . . . cord-023095-4dannjjm 6527 1 None none NN cord-023095-4dannjjm 6527 2 of of IN cord-023095-4dannjjm 6527 3 the the DT cord-023095-4dannjjm 6527 4 20 20 CD cord-023095-4dannjjm 6527 5 annotated annotate VBN cord-023095-4dannjjm 6527 6 genes gene NNS cord-023095-4dannjjm 6527 7 within within IN cord-023095-4dannjjm 6527 8 this this DT cord-023095-4dannjjm 6527 9 target target NN cord-023095-4dannjjm 6527 10 region region NN cord-023095-4dannjjm 6527 11 had have VBD cord-023095-4dannjjm 6527 12 previously previously RB cord-023095-4dannjjm 6527 13 been be VBN cord-023095-4dannjjm 6527 14 associated associate VBN cord-023095-4dannjjm 6527 15 with with IN cord-023095-4dannjjm 6527 16 human human JJ cord-023095-4dannjjm 6527 17 or or CC cord-023095-4dannjjm 6527 18 rodent rodent NN cord-023095-4dannjjm 6527 19 NCL NCL NNP cord-023095-4dannjjm 6527 20 . . . cord-023095-4dannjjm 6528 1 We -PRON- PRP cord-023095-4dannjjm 6528 2 used use VBD cord-023095-4dannjjm 6528 3 DNA DNA NNP cord-023095-4dannjjm 6528 4 from from IN cord-023095-4dannjjm 6528 5 NCL NCL NNP cord-023095-4dannjjm 6528 6 - - HYPH cord-023095-4dannjjm 6528 7 affected affect VBN cord-023095-4dannjjm 6528 8 Tibetan Tibetan NNP cord-023095-4dannjjm 6528 9 Terriers Terriers NNPS cord-023095-4dannjjm 6528 10 to to TO cord-023095-4dannjjm 6528 11 resequence resequence VB cord-023095-4dannjjm 6528 12 the the DT cord-023095-4dannjjm 6528 13 coding code VBG cord-023095-4dannjjm 6528 14 regions region NNS cord-023095-4dannjjm 6528 15 and and CC cord-023095-4dannjjm 6528 16 intron intron NN cord-023095-4dannjjm 6528 17 - - HYPH cord-023095-4dannjjm 6528 18 exon exon NN cord-023095-4dannjjm 6528 19 borders border NNS cord-023095-4dannjjm 6528 20 of of IN cord-023095-4dannjjm 6528 21 several several JJ cord-023095-4dannjjm 6528 22 genes gene NNS cord-023095-4dannjjm 6528 23 harbored harbor VBN cord-023095-4dannjjm 6528 24 within within IN cord-023095-4dannjjm 6528 25 the the DT cord-023095-4dannjjm 6528 26 target target NN cord-023095-4dannjjm 6528 27 region region NN cord-023095-4dannjjm 6528 28 and and CC cord-023095-4dannjjm 6528 29 found find VBD cord-023095-4dannjjm 6528 30 a a DT cord-023095-4dannjjm 6528 31 single single JJ cord-023095-4dannjjm 6528 32 base base NN cord-023095-4dannjjm 6528 33 pair pair NN cord-023095-4dannjjm 6528 34 deletion deletion NN cord-023095-4dannjjm 6528 35 , , , cord-023095-4dannjjm 6528 36 c.1623delG c.1623delG NNP cord-023095-4dannjjm 6528 37 , , , cord-023095-4dannjjm 6528 38 in in IN cord-023095-4dannjjm 6528 39 exon exon NN cord-023095-4dannjjm 6528 40 16 16 CD cord-023095-4dannjjm 6528 41 of of IN cord-023095-4dannjjm 6528 42 positional positional JJ cord-023095-4dannjjm 6528 43 candidate candidate NN cord-023095-4dannjjm 6528 44 ATP13A2 ATP13A2 NNP cord-023095-4dannjjm 6528 45 . . . cord-023095-4dannjjm 6529 1 This this DT cord-023095-4dannjjm 6529 2 deletion deletion NN cord-023095-4dannjjm 6529 3 produces produce VBZ cord-023095-4dannjjm 6529 4 a a DT cord-023095-4dannjjm 6529 5 frame frame NN cord-023095-4dannjjm 6529 6 shift shift NN cord-023095-4dannjjm 6529 7 and and CC cord-023095-4dannjjm 6529 8 a a DT cord-023095-4dannjjm 6529 9 predicted predict VBN cord-023095-4dannjjm 6529 10 premature premature JJ cord-023095-4dannjjm 6529 11 termination termination NN cord-023095-4dannjjm 6529 12 codon codon NN cord-023095-4dannjjm 6529 13 . . . cord-023095-4dannjjm 6530 1 We -PRON- PRP cord-023095-4dannjjm 6530 2 genotyped genotype VBD cord-023095-4dannjjm 6530 3 all all DT cord-023095-4dannjjm 6530 4 454 454 CD cord-023095-4dannjjm 6530 5 Tibetan Tibetan NNP cord-023095-4dannjjm 6530 6 Terrier Terrier NNP cord-023095-4dannjjm 6530 7 DNA dna NN cord-023095-4dannjjm 6530 8 samples sample NNS cord-023095-4dannjjm 6530 9 in in IN cord-023095-4dannjjm 6530 10 our -PRON- PRP$ cord-023095-4dannjjm 6530 11 collection collection NN cord-023095-4dannjjm 6530 12 and and CC cord-023095-4dannjjm 6530 13 found find VBD cord-023095-4dannjjm 6530 14 all all DT cord-023095-4dannjjm 6530 15 45 45 CD cord-023095-4dannjjm 6530 16 NCL NCL NNP cord-023095-4dannjjm 6530 17 - - HYPH cord-023095-4dannjjm 6530 18 affected affect VBN cord-023095-4dannjjm 6530 19 Tibetan Tibetan NNP cord-023095-4dannjjm 6530 20 Terriers Terriers NNPS cord-023095-4dannjjm 6530 21 to to TO cord-023095-4dannjjm 6530 22 be be VB cord-023095-4dannjjm 6530 23 homozygous homozygous JJ cord-023095-4dannjjm 6530 24 for for IN cord-023095-4dannjjm 6530 25 the the DT cord-023095-4dannjjm 6530 26 c.1623delG c.1623delG NNP cord-023095-4dannjjm 6530 27 allele allele NN cord-023095-4dannjjm 6530 28 . . . cord-023095-4dannjjm 6531 1 Eleven eleven CD cord-023095-4dannjjm 6531 2 additional additional JJ cord-023095-4dannjjm 6531 3 c.1623delG c.1623delG NNP cord-023095-4dannjjm 6531 4 homozygotes homozygote NNS cord-023095-4dannjjm 6531 5 were be VBD cord-023095-4dannjjm 6531 6 either either CC cord-023095-4dannjjm 6531 7 less less JJR cord-023095-4dannjjm 6531 8 than than IN cord-023095-4dannjjm 6531 9 5 5 CD cord-023095-4dannjjm 6531 10 years year NNS cord-023095-4dannjjm 6531 11 old old JJ cord-023095-4dannjjm 6531 12 , , , cord-023095-4dannjjm 6531 13 or or CC cord-023095-4dannjjm 6531 14 lost lose VBD cord-023095-4dannjjm 6531 15 to to TO cord-023095-4dannjjm 6531 16 follow follow VB cord-023095-4dannjjm 6531 17 up up RP cord-023095-4dannjjm 6531 18 . . . cord-023095-4dannjjm 6532 1 There there EX cord-023095-4dannjjm 6532 2 were be VBD cord-023095-4dannjjm 6532 3 no no DT cord-023095-4dannjjm 6532 4 known know VBN cord-023095-4dannjjm 6532 5 cases case NNS cord-023095-4dannjjm 6532 6 of of IN cord-023095-4dannjjm 6532 7 NCL NCL NNP cord-023095-4dannjjm 6532 8 in in IN cord-023095-4dannjjm 6532 9 the the DT cord-023095-4dannjjm 6532 10 remaining remain VBG cord-023095-4dannjjm 6532 11 398 398 CD cord-023095-4dannjjm 6532 12 Tibetan Tibetan NNP cord-023095-4dannjjm 6532 13 Terriers Terriers NNPS cord-023095-4dannjjm 6532 14 which which WDT cord-023095-4dannjjm 6532 15 were be VBD cord-023095-4dannjjm 6532 16 either either DT cord-023095-4dannjjm 6532 17 heterozygous heterozygous JJ cord-023095-4dannjjm 6532 18 ( ( -LRB- cord-023095-4dannjjm 6532 19 n n NN cord-023095-4dannjjm 6532 20 5 5 CD cord-023095-4dannjjm 6532 21 149 149 CD cord-023095-4dannjjm 6532 22 ) ) -RRB- cord-023095-4dannjjm 6532 23 or or CC cord-023095-4dannjjm 6532 24 homozygous homozygous JJ cord-023095-4dannjjm 6532 25 for for IN cord-023095-4dannjjm 6532 26 the the DT cord-023095-4dannjjm 6532 27 ancestral ancestral JJ cord-023095-4dannjjm 6532 28 allele allele NN cord-023095-4dannjjm 6532 29 ( ( -LRB- cord-023095-4dannjjm 6532 30 n n NN cord-023095-4dannjjm 6532 31 5 5 CD cord-023095-4dannjjm 6532 32 249 249 CD cord-023095-4dannjjm 6532 33 ) ) -RRB- cord-023095-4dannjjm 6532 34 . . . cord-023095-4dannjjm 6533 1 ATP13A2 atp13a2 NN cord-023095-4dannjjm 6533 2 is be VBZ cord-023095-4dannjjm 6533 3 a a DT cord-023095-4dannjjm 6533 4 member member NN cord-023095-4dannjjm 6533 5 of of IN cord-023095-4dannjjm 6533 6 group group NN cord-023095-4dannjjm 6533 7 of of IN cord-023095-4dannjjm 6533 8 ion ion NN cord-023095-4dannjjm 6533 9 transport transport NN cord-023095-4dannjjm 6533 10 genes gene NNS cord-023095-4dannjjm 6533 11 and and CC cord-023095-4dannjjm 6533 12 has have VBZ cord-023095-4dannjjm 6533 13 been be VBN cord-023095-4dannjjm 6533 14 associated associate VBN cord-023095-4dannjjm 6533 15 with with IN cord-023095-4dannjjm 6533 16 lysosomes lysosome NNS cord-023095-4dannjjm 6533 17 . . . cord-023095-4dannjjm 6534 1 Mutations mutation NNS cord-023095-4dannjjm 6534 2 in in IN cord-023095-4dannjjm 6534 3 human human JJ cord-023095-4dannjjm 6534 4 ATP13A2 atp13a2 NN cord-023095-4dannjjm 6534 5 cause cause IN cord-023095-4dannjjm 6534 6 Kufor Kufor NNP cord-023095-4dannjjm 6534 7 - - HYPH cord-023095-4dannjjm 6534 8 Rakeb Rakeb NNP cord-023095-4dannjjm 6534 9 syndrome syndrome NN cord-023095-4dannjjm 6534 10 ( ( -LRB- cord-023095-4dannjjm 6534 11 KRS KRS NNP cord-023095-4dannjjm 6534 12 ) ) -RRB- cord-023095-4dannjjm 6534 13 , , , cord-023095-4dannjjm 6534 14 a a DT cord-023095-4dannjjm 6534 15 rare rare JJ cord-023095-4dannjjm 6534 16 neurodegenerative neurodegenerative JJ cord-023095-4dannjjm 6534 17 disorder disorder NN cord-023095-4dannjjm 6534 18 with with IN cord-023095-4dannjjm 6534 19 clinical clinical JJ cord-023095-4dannjjm 6534 20 features feature NNS cord-023095-4dannjjm 6534 21 that that WDT cord-023095-4dannjjm 6534 22 include include VBP cord-023095-4dannjjm 6534 23 parkinsonism parkinsonism NN cord-023095-4dannjjm 6534 24 plus plus CC cord-023095-4dannjjm 6534 25 spasticity spasticity NN cord-023095-4dannjjm 6534 26 , , , cord-023095-4dannjjm 6534 27 supranuclear supranuclear NNP cord-023095-4dannjjm 6534 28 upgaze upgaze NNP cord-023095-4dannjjm 6534 29 paresis paresis NNP cord-023095-4dannjjm 6534 30 , , , cord-023095-4dannjjm 6534 31 and and CC cord-023095-4dannjjm 6534 32 dementia dementia NN cord-023095-4dannjjm 6534 33 . . . cord-023095-4dannjjm 6535 1 Post post JJ cord-023095-4dannjjm 6535 2 - - JJ cord-023095-4dannjjm 6535 3 mortem mortem JJ cord-023095-4dannjjm 6535 4 findings finding NNS cord-023095-4dannjjm 6535 5 in in IN cord-023095-4dannjjm 6535 6 KRS KRS NNP cord-023095-4dannjjm 6535 7 have have VBP cord-023095-4dannjjm 6535 8 not not RB cord-023095-4dannjjm 6535 9 been be VBN cord-023095-4dannjjm 6535 10 reported report VBN cord-023095-4dannjjm 6535 11 . . . cord-023095-4dannjjm 6536 1 We -PRON- PRP cord-023095-4dannjjm 6536 2 conclude conclude VBP cord-023095-4dannjjm 6536 3 that that IN cord-023095-4dannjjm 6536 4 NCL NCL NNP cord-023095-4dannjjm 6536 5 in in IN cord-023095-4dannjjm 6536 6 Tibetan tibetan JJ cord-023095-4dannjjm 6536 7 terriers terrier NNS cord-023095-4dannjjm 6536 8 is be VBZ cord-023095-4dannjjm 6536 9 caused cause VBN cord-023095-4dannjjm 6536 10 by by IN cord-023095-4dannjjm 6536 11 a a DT cord-023095-4dannjjm 6536 12 mutation mutation NN cord-023095-4dannjjm 6536 13 in in IN cord-023095-4dannjjm 6536 14 ATP13A2 atp13a2 NN cord-023095-4dannjjm 6536 15 . . . cord-023095-4dannjjm 6537 1 Our -PRON- PRP$ cord-023095-4dannjjm 6537 2 results result NNS cord-023095-4dannjjm 6537 3 suggest suggest VBP cord-023095-4dannjjm 6537 4 that that IN cord-023095-4dannjjm 6537 5 KRS KRS NNP cord-023095-4dannjjm 6537 6 may may MD cord-023095-4dannjjm 6537 7 be be VB cord-023095-4dannjjm 6537 8 a a DT cord-023095-4dannjjm 6537 9 form form NN cord-023095-4dannjjm 6537 10 of of IN cord-023095-4dannjjm 6537 11 adult adult NN cord-023095-4dannjjm 6537 12 onset onset NN cord-023095-4dannjjm 6537 13 NCL NCL NNP cord-023095-4dannjjm 6537 14 in in IN cord-023095-4dannjjm 6537 15 humans human NNS cord-023095-4dannjjm 6537 16 . . . cord-023095-4dannjjm 6538 1 Niemann Niemann NNP cord-023095-4dannjjm 6538 2 - - HYPH cord-023095-4dannjjm 6538 3 Pick Pick NNP cord-023095-4dannjjm 6538 4 type type NN cord-023095-4dannjjm 6538 5 C c NN cord-023095-4dannjjm 6538 6 ( ( -LRB- cord-023095-4dannjjm 6538 7 NPC NPC NNP cord-023095-4dannjjm 6538 8 ) ) -RRB- cord-023095-4dannjjm 6538 9 disease disease NN cord-023095-4dannjjm 6538 10 is be VBZ cord-023095-4dannjjm 6538 11 a a DT cord-023095-4dannjjm 6538 12 progressive progressive JJ cord-023095-4dannjjm 6538 13 neurological neurological JJ cord-023095-4dannjjm 6538 14 disorder disorder NN cord-023095-4dannjjm 6538 15 characterized characterize VBN cord-023095-4dannjjm 6538 16 by by IN cord-023095-4dannjjm 6538 17 dementia dementia NN cord-023095-4dannjjm 6538 18 and and CC cord-023095-4dannjjm 6538 19 ataxia ataxia NN cord-023095-4dannjjm 6538 20 , , , cord-023095-4dannjjm 6538 21 hepatic hepatic JJ cord-023095-4dannjjm 6538 22 and and CC cord-023095-4dannjjm 6538 23 pulmonary pulmonary JJ cord-023095-4dannjjm 6538 24 disease disease NN cord-023095-4dannjjm 6538 25 , , , cord-023095-4dannjjm 6538 26 and and CC cord-023095-4dannjjm 6538 27 death death NN cord-023095-4dannjjm 6538 28 typically typically RB cord-023095-4dannjjm 6538 29 within within IN cord-023095-4dannjjm 6538 30 the the DT cord-023095-4dannjjm 6538 31 first first JJ cord-023095-4dannjjm 6538 32 or or CC cord-023095-4dannjjm 6538 33 second second JJ cord-023095-4dannjjm 6538 34 decade decade NN cord-023095-4dannjjm 6538 35 . . . cord-023095-4dannjjm 6539 1 Despite despite IN cord-023095-4dannjjm 6539 2 the the DT cord-023095-4dannjjm 6539 3 identification identification NN cord-023095-4dannjjm 6539 4 of of IN cord-023095-4dannjjm 6539 5 causative causative JJ cord-023095-4dannjjm 6539 6 mutations mutation NNS cord-023095-4dannjjm 6539 7 , , , cord-023095-4dannjjm 6539 8 the the DT cord-023095-4dannjjm 6539 9 pathogenesis pathogenesis NN cord-023095-4dannjjm 6539 10 is be VBZ cord-023095-4dannjjm 6539 11 not not RB cord-023095-4dannjjm 6539 12 clear clear JJ cord-023095-4dannjjm 6539 13 and and CC cord-023095-4dannjjm 6539 14 therapies therapy NNS cord-023095-4dannjjm 6539 15 to to TO cord-023095-4dannjjm 6539 16 successfully successfully RB cord-023095-4dannjjm 6539 17 treat treat VB cord-023095-4dannjjm 6539 18 NPC NPC NNP cord-023095-4dannjjm 6539 19 disease disease NN cord-023095-4dannjjm 6539 20 have have VBP cord-023095-4dannjjm 6539 21 been be VBN cord-023095-4dannjjm 6539 22 ineffective ineffective JJ cord-023095-4dannjjm 6539 23 to to IN cord-023095-4dannjjm 6539 24 date date NN cord-023095-4dannjjm 6539 25 . . . cord-023095-4dannjjm 6540 1 The the DT cord-023095-4dannjjm 6540 2 recent recent JJ cord-023095-4dannjjm 6540 3 use use NN cord-023095-4dannjjm 6540 4 of of IN cord-023095-4dannjjm 6540 5 intravenously intravenously RB cord-023095-4dannjjm 6540 6 administered administer VBN cord-023095-4dannjjm 6540 7 2-hydroxypropylbeta 2-hydroxypropylbeta CD cord-023095-4dannjjm 6540 8 - - HYPH cord-023095-4dannjjm 6540 9 cyclodextrin cyclodextrin NN cord-023095-4dannjjm 6540 10 ( ( -LRB- cord-023095-4dannjjm 6540 11 HPBCD HPBCD NNP cord-023095-4dannjjm 6540 12 ) ) -RRB- cord-023095-4dannjjm 6540 13 , , , cord-023095-4dannjjm 6540 14 an an DT cord-023095-4dannjjm 6540 15 FDA FDA NNP cord-023095-4dannjjm 6540 16 - - HYPH cord-023095-4dannjjm 6540 17 designated designate VBN cord-023095-4dannjjm 6540 18 orphan orphan NN cord-023095-4dannjjm 6540 19 drug drug NN cord-023095-4dannjjm 6540 20 ( ( -LRB- cord-023095-4dannjjm 6540 21 May May NNP cord-023095-4dannjjm 6540 22 2010 2010 CD cord-023095-4dannjjm 6540 23 ) ) -RRB- cord-023095-4dannjjm 6540 24 , , , cord-023095-4dannjjm 6540 25 in in IN cord-023095-4dannjjm 6540 26 a a DT cord-023095-4dannjjm 6540 27 small small JJ cord-023095-4dannjjm 6540 28 number number NN cord-023095-4dannjjm 6540 29 of of IN cord-023095-4dannjjm 6540 30 children child NNS cord-023095-4dannjjm 6540 31 with with IN cord-023095-4dannjjm 6540 32 NPC NPC NNP cord-023095-4dannjjm 6540 33 disease disease NN cord-023095-4dannjjm 6540 34 is be VBZ cord-023095-4dannjjm 6540 35 based base VBN cord-023095-4dannjjm 6540 36 on on IN cord-023095-4dannjjm 6540 37 favorable favorable JJ cord-023095-4dannjjm 6540 38 treatment treatment NN cord-023095-4dannjjm 6540 39 outcome outcome NN cord-023095-4dannjjm 6540 40 data datum NNS cord-023095-4dannjjm 6540 41 in in IN cord-023095-4dannjjm 6540 42 subcutaneously subcutaneously RB cord-023095-4dannjjm 6540 43 treated treat VBN cord-023095-4dannjjm 6540 44 mouse mouse NN cord-023095-4dannjjm 6540 45 and and CC cord-023095-4dannjjm 6540 46 cat cat NN cord-023095-4dannjjm 6540 47 models model NNS cord-023095-4dannjjm 6540 48 . . . cord-023095-4dannjjm 6541 1 To to TO cord-023095-4dannjjm 6541 2 rigorously rigorously RB cord-023095-4dannjjm 6541 3 evaluate evaluate VB cord-023095-4dannjjm 6541 4 the the DT cord-023095-4dannjjm 6541 5 mechanistic mechanistic JJ cord-023095-4dannjjm 6541 6 , , , cord-023095-4dannjjm 6541 7 pharmacologic pharmacologic JJ cord-023095-4dannjjm 6541 8 , , , cord-023095-4dannjjm 6541 9 and and CC cord-023095-4dannjjm 6541 10 toxicity toxicity NN cord-023095-4dannjjm 6541 11 issues issue NNS cord-023095-4dannjjm 6541 12 associated associate VBN cord-023095-4dannjjm 6541 13 with with IN cord-023095-4dannjjm 6541 14 HPBCD HPBCD NNP cord-023095-4dannjjm 6541 15 therapy therapy NN cord-023095-4dannjjm 6541 16 in in IN cord-023095-4dannjjm 6541 17 NPC NPC NNP cord-023095-4dannjjm 6541 18 disease disease NN cord-023095-4dannjjm 6541 19 , , , cord-023095-4dannjjm 6541 20 we -PRON- PRP cord-023095-4dannjjm 6541 21 have have VBP cord-023095-4dannjjm 6541 22 utilized utilize VBN cord-023095-4dannjjm 6541 23 the the DT cord-023095-4dannjjm 6541 24 spontaneous spontaneous JJ cord-023095-4dannjjm 6541 25 feline feline JJ cord-023095-4dannjjm 6541 26 NPC NPC NNP cord-023095-4dannjjm 6541 27 model model NN cord-023095-4dannjjm 6541 28 harboring harbor VBG cord-023095-4dannjjm 6541 29 a a DT cord-023095-4dannjjm 6541 30 missense missense JJ cord-023095-4dannjjm 6541 31 mutation mutation NN cord-023095-4dannjjm 6541 32 in in IN cord-023095-4dannjjm 6541 33 NPC1 NPC1 NNP cord-023095-4dannjjm 6541 34 ( ( -LRB- cord-023095-4dannjjm 6541 35 pC955S pC955S NNP cord-023095-4dannjjm 6541 36 ) ) -RRB- cord-023095-4dannjjm 6541 37 , , , cord-023095-4dannjjm 6541 38 orthologous orthologous NNP cord-023095-4dannjjm 6541 39 to to IN cord-023095-4dannjjm 6541 40 the the DT cord-023095-4dannjjm 6541 41 most most RBS cord-023095-4dannjjm 6541 42 common common JJ cord-023095-4dannjjm 6541 43 mutation mutation NN cord-023095-4dannjjm 6541 44 in in IN cord-023095-4dannjjm 6541 45 juvenile juvenile JJ cord-023095-4dannjjm 6541 46 - - HYPH cord-023095-4dannjjm 6541 47 onset onset NN cord-023095-4dannjjm 6541 48 patients patient NNS cord-023095-4dannjjm 6541 49 . . . cord-023095-4dannjjm 6542 1 The the DT cord-023095-4dannjjm 6542 2 feline feline JJ cord-023095-4dannjjm 6542 3 NPC NPC NNP cord-023095-4dannjjm 6542 4 model model NN cord-023095-4dannjjm 6542 5 has have VBZ cord-023095-4dannjjm 6542 6 clinical clinical JJ cord-023095-4dannjjm 6542 7 , , , cord-023095-4dannjjm 6542 8 neuropathological neuropathological JJ cord-023095-4dannjjm 6542 9 and and CC cord-023095-4dannjjm 6542 10 biochemical biochemical JJ cord-023095-4dannjjm 6542 11 abnormalities abnormality NNS cord-023095-4dannjjm 6542 12 similar similar JJ cord-023095-4dannjjm 6542 13 to to IN cord-023095-4dannjjm 6542 14 those those DT cord-023095-4dannjjm 6542 15 present present JJ cord-023095-4dannjjm 6542 16 in in IN cord-023095-4dannjjm 6542 17 juvenile juvenile JJ cord-023095-4dannjjm 6542 18 - - HYPH cord-023095-4dannjjm 6542 19 onset onset NN cord-023095-4dannjjm 6542 20 patients patient NNS cord-023095-4dannjjm 6542 21 making make VBG cord-023095-4dannjjm 6542 22 this this DT cord-023095-4dannjjm 6542 23 model model NN cord-023095-4dannjjm 6542 24 homologous homologous JJ cord-023095-4dannjjm 6542 25 to to IN cord-023095-4dannjjm 6542 26 the the DT cord-023095-4dannjjm 6542 27 most most RBS cord-023095-4dannjjm 6542 28 common common JJ cord-023095-4dannjjm 6542 29 disease disease NN cord-023095-4dannjjm 6542 30 form form NN cord-023095-4dannjjm 6542 31 seen see VBN cord-023095-4dannjjm 6542 32 in in IN cord-023095-4dannjjm 6542 33 human human JJ cord-023095-4dannjjm 6542 34 patients patient NNS cord-023095-4dannjjm 6542 35 . . . cord-023095-4dannjjm 6543 1 We -PRON- PRP cord-023095-4dannjjm 6543 2 identified identify VBD cord-023095-4dannjjm 6543 3 that that IN cord-023095-4dannjjm 6543 4 intrathecal intrathecal JJ cord-023095-4dannjjm 6543 5 administration administration NN cord-023095-4dannjjm 6543 6 of of IN cord-023095-4dannjjm 6543 7 HPBCD HPBCD NNP cord-023095-4dannjjm 6543 8 ameliorated ameliorate VBD cord-023095-4dannjjm 6543 9 all all DT cord-023095-4dannjjm 6543 10 clinical clinical JJ cord-023095-4dannjjm 6543 11 aspects aspect NNS cord-023095-4dannjjm 6543 12 of of IN cord-023095-4dannjjm 6543 13 neurological neurological JJ cord-023095-4dannjjm 6543 14 disease disease NN cord-023095-4dannjjm 6543 15 at at IN cord-023095-4dannjjm 6543 16 least least JJS cord-023095-4dannjjm 6543 17 up up IN cord-023095-4dannjjm 6543 18 to to TO cord-023095-4dannjjm 6543 19 24 24 CD cord-023095-4dannjjm 6543 20 weeks week NNS cord-023095-4dannjjm 6543 21 of of IN cord-023095-4dannjjm 6543 22 age age NN cord-023095-4dannjjm 6543 23 ( ( -LRB- cord-023095-4dannjjm 6543 24 an an DT cord-023095-4dannjjm 6543 25 age age NN cord-023095-4dannjjm 6543 26 when when WRB cord-023095-4dannjjm 6543 27 untreated untreated JJ cord-023095-4dannjjm 6543 28 cats cat NNS cord-023095-4dannjjm 6543 29 die die VBP cord-023095-4dannjjm 6543 30 ) ) -RRB- cord-023095-4dannjjm 6543 31 but but CC cord-023095-4dannjjm 6543 32 had have VBD cord-023095-4dannjjm 6543 33 no no DT cord-023095-4dannjjm 6543 34 effect effect NN cord-023095-4dannjjm 6543 35 on on IN cord-023095-4dannjjm 6543 36 hepatic hepatic JJ cord-023095-4dannjjm 6543 37 disease disease NN cord-023095-4dannjjm 6543 38 . . . cord-023095-4dannjjm 6544 1 We -PRON- PRP cord-023095-4dannjjm 6544 2 identified identify VBD cord-023095-4dannjjm 6544 3 that that IN cord-023095-4dannjjm 6544 4 while while IN cord-023095-4dannjjm 6544 5 subcutaneous subcutaneous JJ cord-023095-4dannjjm 6544 6 therapy therapy NN cord-023095-4dannjjm 6544 7 with with IN cord-023095-4dannjjm 6544 8 HPBCD HPBCD NNP cord-023095-4dannjjm 6544 9 at at IN cord-023095-4dannjjm 6544 10 all all DT cord-023095-4dannjjm 6544 11 doses dose NNS cord-023095-4dannjjm 6544 12 ameliorated ameliorate VBD cord-023095-4dannjjm 6544 13 liver liver NN cord-023095-4dannjjm 6544 14 disease disease NN cord-023095-4dannjjm 6544 15 , , , cord-023095-4dannjjm 6544 16 only only RB cord-023095-4dannjjm 6544 17 8000 8000 CD cord-023095-4dannjjm 6544 18 mg mg NNP cord-023095-4dannjjm 6544 19 / / SYM cord-023095-4dannjjm 6544 20 kg kg NNP cord-023095-4dannjjm 6544 21 substantially substantially RB cord-023095-4dannjjm 6544 22 affected affect VBD cord-023095-4dannjjm 6544 23 neurological neurological JJ cord-023095-4dannjjm 6544 24 disease disease NN cord-023095-4dannjjm 6544 25 but but CC cord-023095-4dannjjm 6544 26 also also RB cord-023095-4dannjjm 6544 27 resulted result VBD cord-023095-4dannjjm 6544 28 in in IN cord-023095-4dannjjm 6544 29 early early JJ cord-023095-4dannjjm 6544 30 death death NN cord-023095-4dannjjm 6544 31 due due IN cord-023095-4dannjjm 6544 32 to to IN cord-023095-4dannjjm 6544 33 pulmonary pulmonary JJ cord-023095-4dannjjm 6544 34 toxicity toxicity NN cord-023095-4dannjjm 6544 35 . . . cord-023095-4dannjjm 6545 1 Finally finally RB cord-023095-4dannjjm 6545 2 , , , cord-023095-4dannjjm 6545 3 we -PRON- PRP cord-023095-4dannjjm 6545 4 identified identify VBD cord-023095-4dannjjm 6545 5 a a DT cord-023095-4dannjjm 6545 6 dose dose NN cord-023095-4dannjjm 6545 7 - - HYPH cord-023095-4dannjjm 6545 8 related relate VBN cord-023095-4dannjjm 6545 9 toxic toxic JJ cord-023095-4dannjjm 6545 10 effect effect NN cord-023095-4dannjjm 6545 11 of of IN cord-023095-4dannjjm 6545 12 HPBCD HPBCD NNP cord-023095-4dannjjm 6545 13 on on IN cord-023095-4dannjjm 6545 14 hearing hearing NN cord-023095-4dannjjm 6545 15 function function NN cord-023095-4dannjjm 6545 16 that that WDT cord-023095-4dannjjm 6545 17 had have VBD cord-023095-4dannjjm 6545 18 not not RB cord-023095-4dannjjm 6545 19 been be VBN cord-023095-4dannjjm 6545 20 described describe VBN cord-023095-4dannjjm 6545 21 in in IN cord-023095-4dannjjm 6545 22 any any DT cord-023095-4dannjjm 6545 23 other other JJ cord-023095-4dannjjm 6545 24 species specie NNS cord-023095-4dannjjm 6545 25 . . . cord-023095-4dannjjm 6546 1 Leukodystrophies Leukodystrophies NNP cord-023095-4dannjjm 6546 2 are be VBP cord-023095-4dannjjm 6546 3 disorders disorder NNS cord-023095-4dannjjm 6546 4 of of IN cord-023095-4dannjjm 6546 5 myelin myelin NN cord-023095-4dannjjm 6546 6 synthesis synthesis NN cord-023095-4dannjjm 6546 7 and and CC cord-023095-4dannjjm 6546 8 maintenance maintenance NN cord-023095-4dannjjm 6546 9 that that WDT cord-023095-4dannjjm 6546 10 affect affect VBP cord-023095-4dannjjm 6546 11 CNS CNS NNP cord-023095-4dannjjm 6546 12 myelin myelin NN cord-023095-4dannjjm 6546 13 . . . cord-023095-4dannjjm 6547 1 They -PRON- PRP cord-023095-4dannjjm 6547 2 are be VBP cord-023095-4dannjjm 6547 3 subdivided subdivide VBN cord-023095-4dannjjm 6547 4 as as IN cord-023095-4dannjjm 6547 5 leukodystrophies leukodystrophies NNP cord-023095-4dannjjm 6547 6 , , , cord-023095-4dannjjm 6547 7 hypomyelinating hypomyelinate VBG cord-023095-4dannjjm 6547 8 disorders disorder NNS cord-023095-4dannjjm 6547 9 and and CC cord-023095-4dannjjm 6547 10 spongy spongy JJ cord-023095-4dannjjm 6547 11 degenerations degeneration NNS cord-023095-4dannjjm 6547 12 . . . cord-023095-4dannjjm 6548 1 Although although IN cord-023095-4dannjjm 6548 2 infrequently infrequently RB cord-023095-4dannjjm 6548 3 seen see VBN cord-023095-4dannjjm 6548 4 , , , cord-023095-4dannjjm 6548 5 several several JJ cord-023095-4dannjjm 6548 6 forms form NNS cord-023095-4dannjjm 6548 7 have have VBP cord-023095-4dannjjm 6548 8 been be VBN cord-023095-4dannjjm 6548 9 described describe VBN cord-023095-4dannjjm 6548 10 in in IN cord-023095-4dannjjm 6548 11 various various JJ cord-023095-4dannjjm 6548 12 dog dog NN cord-023095-4dannjjm 6548 13 breeds breed NNS cord-023095-4dannjjm 6548 14 . . . cord-023095-4dannjjm 6549 1 We -PRON- PRP cord-023095-4dannjjm 6549 2 present present VBP cord-023095-4dannjjm 6549 3 a a DT cord-023095-4dannjjm 6549 4 novel novel JJ cord-023095-4dannjjm 6549 5 form form NN cord-023095-4dannjjm 6549 6 of of IN cord-023095-4dannjjm 6549 7 complex complex JJ cord-023095-4dannjjm 6549 8 leukodystrophy leukodystrophy NN cord-023095-4dannjjm 6549 9 consisting consist VBG cord-023095-4dannjjm 6549 10 of of IN cord-023095-4dannjjm 6549 11 hypomyelination hypomyelination NN cord-023095-4dannjjm 6549 12 and and CC cord-023095-4dannjjm 6549 13 spongy spongy JJ cord-023095-4dannjjm 6549 14 degeneration degeneration NN cord-023095-4dannjjm 6549 15 that that WDT cord-023095-4dannjjm 6549 16 presents present VBZ cord-023095-4dannjjm 6549 17 primarily primarily RB cord-023095-4dannjjm 6549 18 with with IN cord-023095-4dannjjm 6549 19 hind hind JJ cord-023095-4dannjjm 6549 20 end end NN cord-023095-4dannjjm 6549 21 tremors tremor NNS cord-023095-4dannjjm 6549 22 in in IN cord-023095-4dannjjm 6549 23 Border Border NNP cord-023095-4dannjjm 6549 24 terrier terrier NN cord-023095-4dannjjm 6549 25 puppies puppy NNS cord-023095-4dannjjm 6549 26 . . . cord-023095-4dannjjm 6550 1 Three three CD cord-023095-4dannjjm 6550 2 Border Border NNP cord-023095-4dannjjm 6550 3 terriers terrier NNS cord-023095-4dannjjm 6550 4 from from IN cord-023095-4dannjjm 6550 5 two two CD cord-023095-4dannjjm 6550 6 different different JJ cord-023095-4dannjjm 6550 7 litters litter NNS cord-023095-4dannjjm 6550 8 ( ( -LRB- cord-023095-4dannjjm 6550 9 and and CC cord-023095-4dannjjm 6550 10 lineages lineage NNS cord-023095-4dannjjm 6550 11 ) ) -RRB- cord-023095-4dannjjm 6550 12 are be VBP cord-023095-4dannjjm 6550 13 described describe VBN cord-023095-4dannjjm 6550 14 here here RB cord-023095-4dannjjm 6550 15 that that WDT cord-023095-4dannjjm 6550 16 presented present VBD cord-023095-4dannjjm 6550 17 with with IN cord-023095-4dannjjm 6550 18 a a DT cord-023095-4dannjjm 6550 19 history history NN cord-023095-4dannjjm 6550 20 of of IN cord-023095-4dannjjm 6550 21 shaking shake VBG cord-023095-4dannjjm 6550 22 movements movement NNS cord-023095-4dannjjm 6550 23 . . . cord-023095-4dannjjm 6551 1 The the DT cord-023095-4dannjjm 6551 2 youngest young JJS cord-023095-4dannjjm 6551 3 dog dog NN cord-023095-4dannjjm 6551 4 was be VBD cord-023095-4dannjjm 6551 5 a a DT cord-023095-4dannjjm 6551 6 3-week 3-week JJ cord-023095-4dannjjm 6551 7 old old JJ cord-023095-4dannjjm 6551 8 male male NN cord-023095-4dannjjm 6551 9 . . . cord-023095-4dannjjm 6552 1 It -PRON- PRP cord-023095-4dannjjm 6552 2 was be VBD cord-023095-4dannjjm 6552 3 the the DT cord-023095-4dannjjm 6552 4 only only JJ cord-023095-4dannjjm 6552 5 dog dog NN cord-023095-4dannjjm 6552 6 affected affect VBN cord-023095-4dannjjm 6552 7 in in IN cord-023095-4dannjjm 6552 8 the the DT cord-023095-4dannjjm 6552 9 litter litter NN cord-023095-4dannjjm 6552 10 . . . cord-023095-4dannjjm 6553 1 The the DT cord-023095-4dannjjm 6553 2 other other JJ cord-023095-4dannjjm 6553 3 two two CD cord-023095-4dannjjm 6553 4 dogs dog NNS cord-023095-4dannjjm 6553 5 were be VBD cord-023095-4dannjjm 6553 6 6-week 6-week JJ cord-023095-4dannjjm 6553 7 old old JJ cord-023095-4dannjjm 6553 8 female female JJ cord-023095-4dannjjm 6553 9 littermates littermate NNS cord-023095-4dannjjm 6553 10 . . . cord-023095-4dannjjm 6554 1 There there EX cord-023095-4dannjjm 6554 2 were be VBD cord-023095-4dannjjm 6554 3 two two CD cord-023095-4dannjjm 6554 4 unaffected unaffected JJ cord-023095-4dannjjm 6554 5 males male NNS cord-023095-4dannjjm 6554 6 in in IN cord-023095-4dannjjm 6554 7 the the DT cord-023095-4dannjjm 6554 8 same same JJ cord-023095-4dannjjm 6554 9 litter litter NN cord-023095-4dannjjm 6554 10 . . . cord-023095-4dannjjm 6555 1 Physical physical JJ cord-023095-4dannjjm 6555 2 examination examination NN cord-023095-4dannjjm 6555 3 revealed reveal VBD cord-023095-4dannjjm 6555 4 no no DT cord-023095-4dannjjm 6555 5 abnormalities abnormality NNS cord-023095-4dannjjm 6555 6 . . . cord-023095-4dannjjm 6556 1 On on IN cord-023095-4dannjjm 6556 2 neurological neurological JJ cord-023095-4dannjjm 6556 3 examination examination NN cord-023095-4dannjjm 6556 4 , , , cord-023095-4dannjjm 6556 5 the the DT cord-023095-4dannjjm 6556 6 affected affect VBN cord-023095-4dannjjm 6556 7 dogs dog NNS cord-023095-4dannjjm 6556 8 displayed display VBD cord-023095-4dannjjm 6556 9 severe severe JJ cord-023095-4dannjjm 6556 10 hind hind NN cord-023095-4dannjjm 6556 11 end end NN cord-023095-4dannjjm 6556 12 tremors tremor NNS cord-023095-4dannjjm 6556 13 , , , cord-023095-4dannjjm 6556 14 with with IN cord-023095-4dannjjm 6556 15 a a DT cord-023095-4dannjjm 6556 16 characteristic characteristic JJ cord-023095-4dannjjm 6556 17 swinging swinge VBG cord-023095-4dannjjm 6556 18 side side NN cord-023095-4dannjjm 6556 19 - - HYPH cord-023095-4dannjjm 6556 20 to to IN cord-023095-4dannjjm 6556 21 - - HYPH cord-023095-4dannjjm 6556 22 side side NN cord-023095-4dannjjm 6556 23 movement movement NN cord-023095-4dannjjm 6556 24 ( ( -LRB- cord-023095-4dannjjm 6556 25 best best RB cord-023095-4dannjjm 6556 26 described describe VBN cord-023095-4dannjjm 6556 27 as as IN cord-023095-4dannjjm 6556 28 ' ' `` cord-023095-4dannjjm 6556 29 ' ' `` cord-023095-4dannjjm 6556 30 rumpshaker rumpshaker NNP cord-023095-4dannjjm 6556 31 ' ' '' cord-023095-4dannjjm 6556 32 ' ' '' cord-023095-4dannjjm 6556 33 ) ) -RRB- cord-023095-4dannjjm 6556 34 . . . cord-023095-4dannjjm 6557 1 The the DT cord-023095-4dannjjm 6557 2 tremors tremor NNS cord-023095-4dannjjm 6557 3 also also RB cord-023095-4dannjjm 6557 4 involved involve VBD cord-023095-4dannjjm 6557 5 the the DT cord-023095-4dannjjm 6557 6 head head NN cord-023095-4dannjjm 6557 7 and and CC cord-023095-4dannjjm 6557 8 thoracic thoracic JJ cord-023095-4dannjjm 6557 9 limbs limb NNS cord-023095-4dannjjm 6557 10 but but CC cord-023095-4dannjjm 6557 11 to to IN cord-023095-4dannjjm 6557 12 a a DT cord-023095-4dannjjm 6557 13 lesser less JJR cord-023095-4dannjjm 6557 14 degree degree NN cord-023095-4dannjjm 6557 15 , , , cord-023095-4dannjjm 6557 16 and and CC cord-023095-4dannjjm 6557 17 disappeared disappear VBD cord-023095-4dannjjm 6557 18 when when WRB cord-023095-4dannjjm 6557 19 the the DT cord-023095-4dannjjm 6557 20 dogs dog NNS cord-023095-4dannjjm 6557 21 were be VBD cord-023095-4dannjjm 6557 22 asleep asleep JJ cord-023095-4dannjjm 6557 23 or or CC cord-023095-4dannjjm 6557 24 at at IN cord-023095-4dannjjm 6557 25 rest rest NN cord-023095-4dannjjm 6557 26 . . . cord-023095-4dannjjm 6558 1 Severe severe JJ cord-023095-4dannjjm 6558 2 cerebellar cerebellar JJ cord-023095-4dannjjm 6558 3 ataxia ataxia NN cord-023095-4dannjjm 6558 4 was be VBD cord-023095-4dannjjm 6558 5 observed observe VBN cord-023095-4dannjjm 6558 6 when when WRB cord-023095-4dannjjm 6558 7 the the DT cord-023095-4dannjjm 6558 8 dogs dog NNS cord-023095-4dannjjm 6558 9 ambulated ambulate VBD cord-023095-4dannjjm 6558 10 . . . cord-023095-4dannjjm 6559 1 Proprioceptive proprioceptive JJ cord-023095-4dannjjm 6559 2 positioning positioning NN cord-023095-4dannjjm 6559 3 was be VBD cord-023095-4dannjjm 6559 4 delayed delay VBN cord-023095-4dannjjm 6559 5 in in IN cord-023095-4dannjjm 6559 6 the the DT cord-023095-4dannjjm 6559 7 pelvic pelvic JJ cord-023095-4dannjjm 6559 8 limbs limb NNS cord-023095-4dannjjm 6559 9 of of IN cord-023095-4dannjjm 6559 10 all all DT cord-023095-4dannjjm 6559 11 3 3 CD cord-023095-4dannjjm 6559 12 dogs dog NNS cord-023095-4dannjjm 6559 13 . . . cord-023095-4dannjjm 6560 1 Spinal spinal JJ cord-023095-4dannjjm 6560 2 reflexes reflex NNS cord-023095-4dannjjm 6560 3 and and CC cord-023095-4dannjjm 6560 4 nociception nociception NN cord-023095-4dannjjm 6560 5 appeared appear VBD cord-023095-4dannjjm 6560 6 normal normal JJ cord-023095-4dannjjm 6560 7 . . . cord-023095-4dannjjm 6561 1 Necropsy Necropsy NNP cord-023095-4dannjjm 6561 2 was be VBD cord-023095-4dannjjm 6561 3 performed perform VBN cord-023095-4dannjjm 6561 4 in in IN cord-023095-4dannjjm 6561 5 all all DT cord-023095-4dannjjm 6561 6 3 3 CD cord-023095-4dannjjm 6561 7 puppies puppy NNS cord-023095-4dannjjm 6561 8 . . . cord-023095-4dannjjm 6562 1 No no DT cord-023095-4dannjjm 6562 2 macroscopic macroscopic JJ cord-023095-4dannjjm 6562 3 changes change NNS cord-023095-4dannjjm 6562 4 were be VBD cord-023095-4dannjjm 6562 5 observed observe VBN cord-023095-4dannjjm 6562 6 . . . cord-023095-4dannjjm 6563 1 Histologic Histologic NNP cord-023095-4dannjjm 6563 2 evaluation evaluation NN cord-023095-4dannjjm 6563 3 of of IN cord-023095-4dannjjm 6563 4 the the DT cord-023095-4dannjjm 6563 5 CNS CNS NNP cord-023095-4dannjjm 6563 6 revealed reveal VBD cord-023095-4dannjjm 6563 7 spongy spongy JJ cord-023095-4dannjjm 6563 8 degeneration degeneration NN cord-023095-4dannjjm 6563 9 and and CC cord-023095-4dannjjm 6563 10 hypomyelination hypomyelination NN cord-023095-4dannjjm 6563 11 in in IN cord-023095-4dannjjm 6563 12 all all DT cord-023095-4dannjjm 6563 13 funiculi funiculus NNS cord-023095-4dannjjm 6563 14 of of IN cord-023095-4dannjjm 6563 15 the the DT cord-023095-4dannjjm 6563 16 cervical cervical JJ cord-023095-4dannjjm 6563 17 and and CC cord-023095-4dannjjm 6563 18 thoracic thoracic JJ cord-023095-4dannjjm 6563 19 spinal spinal JJ cord-023095-4dannjjm 6563 20 cord cord NN cord-023095-4dannjjm 6563 21 . . . cord-023095-4dannjjm 6564 1 White white JJ cord-023095-4dannjjm 6564 2 matter matter NN cord-023095-4dannjjm 6564 3 of of IN cord-023095-4dannjjm 6564 4 the the DT cord-023095-4dannjjm 6564 5 frontal frontal JJ cord-023095-4dannjjm 6564 6 , , , cord-023095-4dannjjm 6564 7 temporal temporal JJ cord-023095-4dannjjm 6564 8 and and CC cord-023095-4dannjjm 6564 9 parietal parietal JJ cord-023095-4dannjjm 6564 10 cortices cortex NNS cord-023095-4dannjjm 6564 11 had have VBD cord-023095-4dannjjm 6564 12 mild mild JJ cord-023095-4dannjjm 6564 13 multifocal multifocal JJ cord-023095-4dannjjm 6564 14 spongy spongy JJ cord-023095-4dannjjm 6564 15 degeneration degeneration NN cord-023095-4dannjjm 6564 16 and and CC cord-023095-4dannjjm 6564 17 hypomyelination hypomyelination NN cord-023095-4dannjjm 6564 18 , , , cord-023095-4dannjjm 6564 19 whereas whereas IN cord-023095-4dannjjm 6564 20 white white JJ cord-023095-4dannjjm 6564 21 matter matter NN cord-023095-4dannjjm 6564 22 of of IN cord-023095-4dannjjm 6564 23 the the DT cord-023095-4dannjjm 6564 24 cerebellum cerebellum NN cord-023095-4dannjjm 6564 25 , , , cord-023095-4dannjjm 6564 26 medulla medulla NN cord-023095-4dannjjm 6564 27 and and CC cord-023095-4dannjjm 6564 28 pons pons NNP cord-023095-4dannjjm 6564 29 showed show VBD cord-023095-4dannjjm 6564 30 severe severe JJ cord-023095-4dannjjm 6564 31 diffuse diffuse JJ cord-023095-4dannjjm 6564 32 spongy spongy JJ cord-023095-4dannjjm 6564 33 degeneration degeneration NN cord-023095-4dannjjm 6564 34 and and CC cord-023095-4dannjjm 6564 35 hypomyelination hypomyelination NN cord-023095-4dannjjm 6564 36 with with IN cord-023095-4dannjjm 6564 37 gliosis gliosis NNP cord-023095-4dannjjm 6564 38 . . . cord-023095-4dannjjm 6565 1 The the DT cord-023095-4dannjjm 6565 2 combination combination NN cord-023095-4dannjjm 6565 3 of of IN cord-023095-4dannjjm 6565 4 reduced reduce VBN cord-023095-4dannjjm 6565 5 myelin myelin NN cord-023095-4dannjjm 6565 6 formation formation NN cord-023095-4dannjjm 6565 7 combined combine VBN cord-023095-4dannjjm 6565 8 with with IN cord-023095-4dannjjm 6565 9 spongiform spongiform JJ cord-023095-4dannjjm 6565 10 white white JJ cord-023095-4dannjjm 6565 11 matter matter NN cord-023095-4dannjjm 6565 12 changes change NNS cord-023095-4dannjjm 6565 13 in in IN cord-023095-4dannjjm 6565 14 the the DT cord-023095-4dannjjm 6565 15 absence absence NN cord-023095-4dannjjm 6565 16 of of IN cord-023095-4dannjjm 6565 17 microglial microglial JJ cord-023095-4dannjjm 6565 18 responses response NNS cord-023095-4dannjjm 6565 19 suggest suggest VBP cord-023095-4dannjjm 6565 20 a a DT cord-023095-4dannjjm 6565 21 complex complex JJ cord-023095-4dannjjm 6565 22 pathogenesis pathogenesis NN cord-023095-4dannjjm 6565 23 affecting affect VBG cord-023095-4dannjjm 6565 24 both both CC cord-023095-4dannjjm 6565 25 oligodendrocytes oligodendrocyte NNS cord-023095-4dannjjm 6565 26 ' ' POS cord-023095-4dannjjm 6565 27 capacity capacity NN cord-023095-4dannjjm 6565 28 to to TO cord-023095-4dannjjm 6565 29 synthesize synthesize VB cord-023095-4dannjjm 6565 30 myelin myelin NN cord-023095-4dannjjm 6565 31 and and CC cord-023095-4dannjjm 6565 32 the the DT cord-023095-4dannjjm 6565 33 stability stability NN cord-023095-4dannjjm 6565 34 of of IN cord-023095-4dannjjm 6565 35 the the DT cord-023095-4dannjjm 6565 36 myelin myelin NN cord-023095-4dannjjm 6565 37 that that WDT cord-023095-4dannjjm 6565 38 was be VBD cord-023095-4dannjjm 6565 39 formed form VBN cord-023095-4dannjjm 6565 40 . . . cord-023095-4dannjjm 6566 1 The the DT cord-023095-4dannjjm 6566 2 number number NN cord-023095-4dannjjm 6566 3 of of IN cord-023095-4dannjjm 6566 4 oligodendrocytes oligodendrocyte NNS cord-023095-4dannjjm 6566 5 and and CC cord-023095-4dannjjm 6566 6 axons axon NNS cord-023095-4dannjjm 6566 7 appeared appear VBD cord-023095-4dannjjm 6566 8 subjectively subjectively RB cord-023095-4dannjjm 6566 9 normal normal JJ cord-023095-4dannjjm 6566 10 indicating indicate VBG cord-023095-4dannjjm 6566 11 a a DT cord-023095-4dannjjm 6566 12 primarily primarily RB cord-023095-4dannjjm 6566 13 hypomyelinating hypomyelinating JJ cord-023095-4dannjjm 6566 14 process process NN cord-023095-4dannjjm 6566 15 . . . cord-023095-4dannjjm 6567 1 The the DT cord-023095-4dannjjm 6567 2 clinical clinical JJ cord-023095-4dannjjm 6567 3 and and CC cord-023095-4dannjjm 6567 4 pathological pathological JJ cord-023095-4dannjjm 6567 5 features feature NNS cord-023095-4dannjjm 6567 6 of of IN cord-023095-4dannjjm 6567 7 this this DT cord-023095-4dannjjm 6567 8 disease disease NN cord-023095-4dannjjm 6567 9 have have VBP cord-023095-4dannjjm 6567 10 not not RB cord-023095-4dannjjm 6567 11 been be VBN cord-023095-4dannjjm 6567 12 described describe VBN cord-023095-4dannjjm 6567 13 in in IN cord-023095-4dannjjm 6567 14 any any DT cord-023095-4dannjjm 6567 15 other other JJ cord-023095-4dannjjm 6567 16 canine canine JJ cord-023095-4dannjjm 6567 17 leukodystrophy leukodystrophy NN cord-023095-4dannjjm 6567 18 . . . cord-023095-4dannjjm 6568 1 The the DT cord-023095-4dannjjm 6568 2 primary primary JJ cord-023095-4dannjjm 6568 3 and and CC cord-023095-4dannjjm 6568 4 most most RBS cord-023095-4dannjjm 6568 5 striking striking JJ cord-023095-4dannjjm 6568 6 clinical clinical JJ cord-023095-4dannjjm 6568 7 feature feature NN cord-023095-4dannjjm 6568 8 is be VBZ cord-023095-4dannjjm 6568 9 the the DT cord-023095-4dannjjm 6568 10 presence presence NN cord-023095-4dannjjm 6568 11 of of IN cord-023095-4dannjjm 6568 12 severe severe JJ cord-023095-4dannjjm 6568 13 tremors tremor NNS cord-023095-4dannjjm 6568 14 in in IN cord-023095-4dannjjm 6568 15 the the DT cord-023095-4dannjjm 6568 16 hind hind NN cord-023095-4dannjjm 6568 17 end end NN cord-023095-4dannjjm 6568 18 , , , cord-023095-4dannjjm 6568 19 causing cause VBG cord-023095-4dannjjm 6568 20 the the DT cord-023095-4dannjjm 6568 21 ' ' `` cord-023095-4dannjjm 6568 22 ' ' `` cord-023095-4dannjjm 6568 23 rumpshaker rumpshaker NN cord-023095-4dannjjm 6568 24 ' ' '' cord-023095-4dannjjm 6568 25 ' ' '' cord-023095-4dannjjm 6568 26 pheynotype pheynotype NN cord-023095-4dannjjm 6568 27 . . . cord-023095-4dannjjm 6569 1 Genetic genetic JJ cord-023095-4dannjjm 6569 2 studies study NNS cord-023095-4dannjjm 6569 3 are be VBP cord-023095-4dannjjm 6569 4 underway underway JJ cord-023095-4dannjjm 6569 5 to to TO cord-023095-4dannjjm 6569 6 determine determine VB cord-023095-4dannjjm 6569 7 if if IN cord-023095-4dannjjm 6569 8 the the DT cord-023095-4dannjjm 6569 9 disease disease NN cord-023095-4dannjjm 6569 10 is be VBZ cord-023095-4dannjjm 6569 11 inherited inherit VBN cord-023095-4dannjjm 6569 12 and and CC cord-023095-4dannjjm 6569 13 the the DT cord-023095-4dannjjm 6569 14 inheritance inheritance NN cord-023095-4dannjjm 6569 15 mode mode NN cord-023095-4dannjjm 6569 16 . . . cord-023095-4dannjjm 6570 1 A a DT cord-023095-4dannjjm 6570 2 syndrome syndrome NN cord-023095-4dannjjm 6570 3 of of IN cord-023095-4dannjjm 6570 4 Border border NN cord-023095-4dannjjm 6570 5 collie collie NN cord-023095-4dannjjm 6570 6 collapse collapse NN cord-023095-4dannjjm 6570 7 ( ( -LRB- cord-023095-4dannjjm 6570 8 BCC BCC NNP cord-023095-4dannjjm 6570 9 ) ) -RRB- cord-023095-4dannjjm 6570 10 appears appear VBZ cord-023095-4dannjjm 6570 11 to to TO cord-023095-4dannjjm 6570 12 be be VB cord-023095-4dannjjm 6570 13 common common JJ cord-023095-4dannjjm 6570 14 in in IN cord-023095-4dannjjm 6570 15 dogs dog NNS cord-023095-4dannjjm 6570 16 used use VBN cord-023095-4dannjjm 6570 17 for for IN cord-023095-4dannjjm 6570 18 working work VBG cord-023095-4dannjjm 6570 19 stock stock NN cord-023095-4dannjjm 6570 20 . . . cord-023095-4dannjjm 6571 1 This this DT cord-023095-4dannjjm 6571 2 syndrome syndrome NN cord-023095-4dannjjm 6571 3 has have VBZ cord-023095-4dannjjm 6571 4 also also RB cord-023095-4dannjjm 6571 5 been be VBN cord-023095-4dannjjm 6571 6 called call VBN cord-023095-4dannjjm 6571 7 malignant malignant JJ cord-023095-4dannjjm 6571 8 hyperthermia hyperthermia NN cord-023095-4dannjjm 6571 9 , , , cord-023095-4dannjjm 6571 10 heat heat NN cord-023095-4dannjjm 6571 11 intolerance intolerance NN cord-023095-4dannjjm 6571 12 , , , cord-023095-4dannjjm 6571 13 exerciseinduced exerciseinduced JJ cord-023095-4dannjjm 6571 14 collapse collapse NN cord-023095-4dannjjm 6571 15 and and CC cord-023095-4dannjjm 6571 16 ' ' '' cord-023095-4dannjjm 6571 17 ' ' `` cord-023095-4dannjjm 6571 18 wobbles wobble NNS cord-023095-4dannjjm 6571 19 ' ' '' cord-023095-4dannjjm 6571 20 ' ' '' cord-023095-4dannjjm 6571 21 . . . cord-023095-4dannjjm 6572 1 A a DT cord-023095-4dannjjm 6572 2 presumptive presumptive JJ cord-023095-4dannjjm 6572 3 diagnosis diagnosis NN cord-023095-4dannjjm 6572 4 of of IN cord-023095-4dannjjm 6572 5 BCC BCC NNP cord-023095-4dannjjm 6572 6 can can MD cord-023095-4dannjjm 6572 7 only only RB cord-023095-4dannjjm 6572 8 be be VB cord-023095-4dannjjm 6572 9 made make VBN cord-023095-4dannjjm 6572 10 by by IN cord-023095-4dannjjm 6572 11 eliminating eliminate VBG cord-023095-4dannjjm 6572 12 other other JJ cord-023095-4dannjjm 6572 13 causes cause NNS cord-023095-4dannjjm 6572 14 of of IN cord-023095-4dannjjm 6572 15 exercise exercise NN cord-023095-4dannjjm 6572 16 intolerance intolerance NN cord-023095-4dannjjm 6572 17 and and CC cord-023095-4dannjjm 6572 18 weakness weakness NN cord-023095-4dannjjm 6572 19 . . . cord-023095-4dannjjm 6573 1 The the DT cord-023095-4dannjjm 6573 2 purpose purpose NN cord-023095-4dannjjm 6573 3 of of IN cord-023095-4dannjjm 6573 4 this this DT cord-023095-4dannjjm 6573 5 study study NN cord-023095-4dannjjm 6573 6 was be VBD cord-023095-4dannjjm 6573 7 to to TO cord-023095-4dannjjm 6573 8 describe describe VB cord-023095-4dannjjm 6573 9 the the DT cord-023095-4dannjjm 6573 10 clinical clinical JJ cord-023095-4dannjjm 6573 11 features feature NNS cord-023095-4dannjjm 6573 12 of of IN cord-023095-4dannjjm 6573 13 collapse collapse NN cord-023095-4dannjjm 6573 14 in in IN cord-023095-4dannjjm 6573 15 affected affected JJ cord-023095-4dannjjm 6573 16 dogs dog NNS cord-023095-4dannjjm 6573 17 and and CC cord-023095-4dannjjm 6573 18 determine determine VBP cord-023095-4dannjjm 6573 19 if if IN cord-023095-4dannjjm 6573 20 there there EX cord-023095-4dannjjm 6573 21 were be VBD cord-023095-4dannjjm 6573 22 characteristic characteristic JJ cord-023095-4dannjjm 6573 23 clinical clinical JJ cord-023095-4dannjjm 6573 24 or or CC cord-023095-4dannjjm 6573 25 laboratory laboratory NN cord-023095-4dannjjm 6573 26 features feature NNS cord-023095-4dannjjm 6573 27 at at IN cord-023095-4dannjjm 6573 28 rest rest NN cord-023095-4dannjjm 6573 29 or or CC cord-023095-4dannjjm 6573 30 after after IN cord-023095-4dannjjm 6573 31 exercise exercise NN cord-023095-4dannjjm 6573 32 that that WDT cord-023095-4dannjjm 6573 33 could could MD cord-023095-4dannjjm 6573 34 aid aid VB cord-023095-4dannjjm 6573 35 in in IN cord-023095-4dannjjm 6573 36 diagnosis diagnosis NN cord-023095-4dannjjm 6573 37 . . . cord-023095-4dannjjm 6574 1 Seven seven CD cord-023095-4dannjjm 6574 2 adult adult NN cord-023095-4dannjjm 6574 3 Border Border NNP cord-023095-4dannjjm 6574 4 collies collie NNS cord-023095-4dannjjm 6574 5 with with IN cord-023095-4dannjjm 6574 6 a a DT cord-023095-4dannjjm 6574 7 history history NN cord-023095-4dannjjm 6574 8 of of IN cord-023095-4dannjjm 6574 9 collapse collapse NN cord-023095-4dannjjm 6574 10 during during IN cord-023095-4dannjjm 6574 11 sheep sheep NN cord-023095-4dannjjm 6574 12 herding herding NN cord-023095-4dannjjm 6574 13 ( ( -LRB- cord-023095-4dannjjm 6574 14 affected affect VBN cord-023095-4dannjjm 6574 15 ) ) -RRB- cord-023095-4dannjjm 6574 16 and and CC cord-023095-4dannjjm 6574 17 5 5 CD cord-023095-4dannjjm 6574 18 adult adult NN cord-023095-4dannjjm 6574 19 Border Border NNP cord-023095-4dannjjm 6574 20 collies collie NNS cord-023095-4dannjjm 6574 21 regularly regularly RB cord-023095-4dannjjm 6574 22 used use VBD cord-023095-4dannjjm 6574 23 for for IN cord-023095-4dannjjm 6574 24 sheep sheep NN cord-023095-4dannjjm 6574 25 herding herding NN cord-023095-4dannjjm 6574 26 but but CC cord-023095-4dannjjm 6574 27 showing show VBG cord-023095-4dannjjm 6574 28 no no DT cord-023095-4dannjjm 6574 29 signs sign NNS cord-023095-4dannjjm 6574 30 of of IN cord-023095-4dannjjm 6574 31 exercise exercise NN cord-023095-4dannjjm 6574 32 intolerance intolerance NN cord-023095-4dannjjm 6574 33 ( ( -LRB- cord-023095-4dannjjm 6574 34 normal normal JJ cord-023095-4dannjjm 6574 35 ) ) -RRB- cord-023095-4dannjjm 6574 36 were be VBD cord-023095-4dannjjm 6574 37 evaluated evaluate VBN cord-023095-4dannjjm 6574 38 before before IN cord-023095-4dannjjm 6574 39 and and CC cord-023095-4dannjjm 6574 40 after after IN cord-023095-4dannjjm 6574 41 participating participate VBG cord-023095-4dannjjm 6574 42 in in IN cord-023095-4dannjjm 6574 43 a a DT cord-023095-4dannjjm 6574 44 videotaped videotape VBN cord-023095-4dannjjm 6574 45 10 10 CD cord-023095-4dannjjm 6574 46 minute minute NN cord-023095-4dannjjm 6574 47 exercise exercise NN cord-023095-4dannjjm 6574 48 protocol protocol NN cord-023095-4dannjjm 6574 49 consisting consist VBG cord-023095-4dannjjm 6574 50 ofa ofa NNP cord-023095-4dannjjm 6574 51 series series NN cord-023095-4dannjjm 6574 52 of of IN cord-023095-4dannjjm 6574 53 continuous continuous JJ cord-023095-4dannjjm 6574 54 short short JJ cord-023095-4dannjjm 6574 55 outruns outrun NNS cord-023095-4dannjjm 6574 56 and and CC cord-023095-4dannjjm 6574 57 fetches fetch VBZ cord-023095-4dannjjm 6574 58 of of IN cord-023095-4dannjjm 6574 59 three three CD cord-023095-4dannjjm 6574 60 sheep sheep NNS cord-023095-4dannjjm 6574 61 in in IN cord-023095-4dannjjm 6574 62 an an DT cord-023095-4dannjjm 6574 63 outdoor outdoor JJ cord-023095-4dannjjm 6574 64 pen pen NN cord-023095-4dannjjm 6574 65 . . . cord-023095-4dannjjm 6575 1 Exercise exercise NN cord-023095-4dannjjm 6575 2 was be VBD cord-023095-4dannjjm 6575 3 halted halt VBN cord-023095-4dannjjm 6575 4 at at IN cord-023095-4dannjjm 6575 5 10 10 CD cord-023095-4dannjjm 6575 6 minutes minute NNS cord-023095-4dannjjm 6575 7 or or CC cord-023095-4dannjjm 6575 8 earlier early RBR cord-023095-4dannjjm 6575 9 if if IN cord-023095-4dannjjm 6575 10 there there EX cord-023095-4dannjjm 6575 11 were be VBD cord-023095-4dannjjm 6575 12 signs sign NNS cord-023095-4dannjjm 6575 13 of of IN cord-023095-4dannjjm 6575 14 gait gait NN cord-023095-4dannjjm 6575 15 or or CC cord-023095-4dannjjm 6575 16 mentation mentation NN cord-023095-4dannjjm 6575 17 abnormalities abnormality NNS cord-023095-4dannjjm 6575 18 . . . cord-023095-4dannjjm 6576 1 Pre pre JJ cord-023095-4dannjjm 6576 2 - - JJ cord-023095-4dannjjm 6576 3 exercise exercise JJ cord-023095-4dannjjm 6576 4 evaluation evaluation NN cord-023095-4dannjjm 6576 5 included include VBD cord-023095-4dannjjm 6576 6 physical physical JJ cord-023095-4dannjjm 6576 7 examination examination NN cord-023095-4dannjjm 6576 8 , , , cord-023095-4dannjjm 6576 9 orthopedic orthopedic NN cord-023095-4dannjjm 6576 10 and and CC cord-023095-4dannjjm 6576 11 neurological neurological JJ cord-023095-4dannjjm 6576 12 exam exam NN cord-023095-4dannjjm 6576 13 . . . cord-023095-4dannjjm 6577 1 Pre pre JJ cord-023095-4dannjjm 6577 2 and and CC cord-023095-4dannjjm 6577 3 immediate immediate JJ cord-023095-4dannjjm 6577 4 post post JJ cord-023095-4dannjjm 6577 5 exercise exercise NN cord-023095-4dannjjm 6577 6 rectal rectal JJ cord-023095-4dannjjm 6577 7 temperature temperature NN cord-023095-4dannjjm 6577 8 , , , cord-023095-4dannjjm 6577 9 pulse pulse NN cord-023095-4dannjjm 6577 10 and and CC cord-023095-4dannjjm 6577 11 respiration respiration NN cord-023095-4dannjjm 6577 12 , , , cord-023095-4dannjjm 6577 13 patellar patellar JJ cord-023095-4dannjjm 6577 14 reflexes reflex NNS cord-023095-4dannjjm 6577 15 , , , cord-023095-4dannjjm 6577 16 ECG ECG NNP cord-023095-4dannjjm 6577 17 , , , cord-023095-4dannjjm 6577 18 CBC CBC NNP cord-023095-4dannjjm 6577 19 , , , cord-023095-4dannjjm 6577 20 serum serum NN cord-023095-4dannjjm 6577 21 biochemistry biochemistry NN cord-023095-4dannjjm 6577 22 profile profile NN cord-023095-4dannjjm 6577 23 , , , cord-023095-4dannjjm 6577 24 cortisol cortisol NN cord-023095-4dannjjm 6577 25 , , , cord-023095-4dannjjm 6577 26 arterial arterial JJ cord-023095-4dannjjm 6577 27 blood blood NN cord-023095-4dannjjm 6577 28 gas gas NN cord-023095-4dannjjm 6577 29 and and CC cord-023095-4dannjjm 6577 30 plasma plasma NN cord-023095-4dannjjm 6577 31 lactate lactate NN cord-023095-4dannjjm 6577 32 and and CC cord-023095-4dannjjm 6577 33 pyruvate pyruvate NN cord-023095-4dannjjm 6577 34 concentrations concentration NNS cord-023095-4dannjjm 6577 35 were be VBD cord-023095-4dannjjm 6577 36 measured measure VBN cord-023095-4dannjjm 6577 37 . . . cord-023095-4dannjjm 6578 1 Clinical clinical JJ cord-023095-4dannjjm 6578 2 parameters parameter NNS cord-023095-4dannjjm 6578 3 ( ( -LRB- cord-023095-4dannjjm 6578 4 gait gait NN cord-023095-4dannjjm 6578 5 , , , cord-023095-4dannjjm 6578 6 temperature temperature NN cord-023095-4dannjjm 6578 7 , , , cord-023095-4dannjjm 6578 8 reflexes reflex NNS cord-023095-4dannjjm 6578 9 ) ) -RRB- cord-023095-4dannjjm 6578 10 and and CC cord-023095-4dannjjm 6578 11 lactate lactate NN cord-023095-4dannjjm 6578 12 and and CC cord-023095-4dannjjm 6578 13 pyruvate pyruvate NN cord-023095-4dannjjm 6578 14 concentrations concentration NNS cord-023095-4dannjjm 6578 15 were be VBD cord-023095-4dannjjm 6578 16 evaluated evaluate VBN cord-023095-4dannjjm 6578 17 at at IN cord-023095-4dannjjm 6578 18 intervals interval NNS cord-023095-4dannjjm 6578 19 up up IN cord-023095-4dannjjm 6578 20 to to TO cord-023095-4dannjjm 6578 21 120 120 CD cord-023095-4dannjjm 6578 22 minutes minute NNS cord-023095-4dannjjm 6578 23 after after IN cord-023095-4dannjjm 6578 24 exercise exercise NN cord-023095-4dannjjm 6578 25 . . . cord-023095-4dannjjm 6579 1 Additional additional JJ cord-023095-4dannjjm 6579 2 testing testing NN cord-023095-4dannjjm 6579 3 in in IN cord-023095-4dannjjm 6579 4 affected affect VBN cord-023095-4dannjjm 6579 5 dogs dog NNS cord-023095-4dannjjm 6579 6 included include VBD cord-023095-4dannjjm 6579 7 measurement measurement NN cord-023095-4dannjjm 6579 8 of of IN cord-023095-4dannjjm 6579 9 acetylcholine acetylcholine NN cord-023095-4dannjjm 6579 10 receptor receptor NN cord-023095-4dannjjm 6579 11 antibodies antibody NNS cord-023095-4dannjjm 6579 12 ( ( -LRB- cord-023095-4dannjjm 6579 13 AChRab achrab JJ cord-023095-4dannjjm 6579 14 ) ) -RRB- cord-023095-4dannjjm 6579 15 and and CC cord-023095-4dannjjm 6579 16 DNA dna NN cord-023095-4dannjjm 6579 17 testing testing NN cord-023095-4dannjjm 6579 18 for for IN cord-023095-4dannjjm 6579 19 dynamin dynamin NN cord-023095-4dannjjm 6579 20 - - HYPH cord-023095-4dannjjm 6579 21 associated associate VBN cord-023095-4dannjjm 6579 22 exercise exercise NN cord-023095-4dannjjm 6580 1 induced induce VBN cord-023095-4dannjjm 6580 2 collapse collapse NN cord-023095-4dannjjm 6580 3 ( ( -LRB- cord-023095-4dannjjm 6580 4 dEIC deic NN cord-023095-4dannjjm 6580 5 ) ) -RRB- cord-023095-4dannjjm 6580 6 and and CC cord-023095-4dannjjm 6580 7 the the DT cord-023095-4dannjjm 6580 8 ryanodine ryanodine JJ cord-023095-4dannjjm 6580 9 receptor receptor NN cord-023095-4dannjjm 6580 10 mutation mutation NN cord-023095-4dannjjm 6580 11 associated associate VBN cord-023095-4dannjjm 6580 12 with with IN cord-023095-4dannjjm 6580 13 canine canine JJ cord-023095-4dannjjm 6580 14 malignant malignant JJ cord-023095-4dannjjm 6580 15 hyperthermia(MH hyperthermia(MH NNS cord-023095-4dannjjm 6580 16 ) ) -RRB- cord-023095-4dannjjm 6580 17 . . . cord-023095-4dannjjm 6581 1 One one CD cord-023095-4dannjjm 6581 2 week week NN cord-023095-4dannjjm 6581 3 after after IN cord-023095-4dannjjm 6581 4 exercise exercise NN cord-023095-4dannjjm 6581 5 affected affect VBN cord-023095-4dannjjm 6581 6 dogs dog NNS cord-023095-4dannjjm 6581 7 had have VBD cord-023095-4dannjjm 6581 8 thoracic thoracic JJ cord-023095-4dannjjm 6581 9 radiographs radiograph NNS cord-023095-4dannjjm 6581 10 and and CC cord-023095-4dannjjm 6581 11 echocardiography echocardiography NN cord-023095-4dannjjm 6581 12 performed perform VBN cord-023095-4dannjjm 6581 13 and and CC cord-023095-4dannjjm 6581 14 were be VBD cord-023095-4dannjjm 6581 15 anesthetized anesthetize VBN cord-023095-4dannjjm 6581 16 for for IN cord-023095-4dannjjm 6581 17 EMG EMG NNP cord-023095-4dannjjm 6581 18 and and CC cord-023095-4dannjjm 6581 19 muscle muscle NN cord-023095-4dannjjm 6581 20 biopsies biopsy NNS cord-023095-4dannjjm 6581 21 . . . cord-023095-4dannjjm 6582 1 There there EX cord-023095-4dannjjm 6582 2 were be VBD cord-023095-4dannjjm 6582 3 no no DT cord-023095-4dannjjm 6582 4 significant significant JJ cord-023095-4dannjjm 6582 5 differences difference NNS cord-023095-4dannjjm 6582 6 in in IN cord-023095-4dannjjm 6582 7 temperature temperature NN cord-023095-4dannjjm 6582 8 , , , cord-023095-4dannjjm 6582 9 pulse pulse NN cord-023095-4dannjjm 6582 10 , , , cord-023095-4dannjjm 6582 11 respiration respiration NN cord-023095-4dannjjm 6582 12 , , , cord-023095-4dannjjm 6582 13 or or CC cord-023095-4dannjjm 6582 14 any any DT cord-023095-4dannjjm 6582 15 laboratory laboratory NN cord-023095-4dannjjm 6582 16 parameter parameter NN cord-023095-4dannjjm 6582 17 at at IN cord-023095-4dannjjm 6582 18 any any DT cord-023095-4dannjjm 6582 19 time time NN cord-023095-4dannjjm 6582 20 point point NN cord-023095-4dannjjm 6582 21 between between IN cord-023095-4dannjjm 6582 22 normal normal JJ cord-023095-4dannjjm 6582 23 and and CC cord-023095-4dannjjm 6582 24 affected affected JJ cord-023095-4dannjjm 6582 25 dogs dog NNS cord-023095-4dannjjm 6582 26 . . . cord-023095-4dannjjm 6583 1 No no DT cord-023095-4dannjjm 6583 2 arrhythmias arrhythmia NNS cord-023095-4dannjjm 6583 3 were be VBD cord-023095-4dannjjm 6583 4 detected detect VBN cord-023095-4dannjjm 6583 5 . . . cord-023095-4dannjjm 6584 1 Affected affected JJ cord-023095-4dannjjm 6584 2 dogs dog NNS cord-023095-4dannjjm 6584 3 were be VBD cord-023095-4dannjjm 6584 4 negative negative JJ cord-023095-4dannjjm 6584 5 for for IN cord-023095-4dannjjm 6584 6 the the DT cord-023095-4dannjjm 6584 7 DNA dna NN cord-023095-4dannjjm 6584 8 mutations mutation NNS cord-023095-4dannjjm 6584 9 tested test VBN cord-023095-4dannjjm 6584 10 and and CC cord-023095-4dannjjm 6584 11 for for IN cord-023095-4dannjjm 6584 12 AChR AChR NNP cord-023095-4dannjjm 6584 13 ab ab NNP cord-023095-4dannjjm 6584 14 . . . cord-023095-4dannjjm 6585 1 Thoracic thoracic JJ cord-023095-4dannjjm 6585 2 radiographs radiograph NNS cord-023095-4dannjjm 6585 3 , , , cord-023095-4dannjjm 6585 4 echocardiograms echocardiogram NNS cord-023095-4dannjjm 6585 5 , , , cord-023095-4dannjjm 6585 6 EMGs EMGs NNP cord-023095-4dannjjm 6585 7 and and CC cord-023095-4dannjjm 6585 8 muscle muscle NN cord-023095-4dannjjm 6585 9 biopsies biopsy NNS cord-023095-4dannjjm 6585 10 were be VBD cord-023095-4dannjjm 6585 11 normal normal JJ cord-023095-4dannjjm 6585 12 . . . cord-023095-4dannjjm 6586 1 The the DT cord-023095-4dannjjm 6586 2 5 5 CD cord-023095-4dannjjm 6586 3 normal normal JJ cord-023095-4dannjjm 6586 4 dogs dog NNS cord-023095-4dannjjm 6586 5 had have VBD cord-023095-4dannjjm 6586 6 no no DT cord-023095-4dannjjm 6586 7 alterations alteration NNS cord-023095-4dannjjm 6586 8 in in IN cord-023095-4dannjjm 6586 9 mentation mentation NN cord-023095-4dannjjm 6586 10 or or CC cord-023095-4dannjjm 6586 11 gait gait NN cord-023095-4dannjjm 6586 12 during during IN cord-023095-4dannjjm 6586 13 or or CC cord-023095-4dannjjm 6586 14 after after IN cord-023095-4dannjjm 6586 15 exercise exercise NN cord-023095-4dannjjm 6586 16 . . . cord-023095-4dannjjm 6587 1 Three three CD cord-023095-4dannjjm 6587 2 of of IN cord-023095-4dannjjm 6587 3 the the DT cord-023095-4dannjjm 6587 4 affected affect VBN cord-023095-4dannjjm 6587 5 dogs dog NNS cord-023095-4dannjjm 6587 6 had have VBD cord-023095-4dannjjm 6587 7 exercise exercise NN cord-023095-4dannjjm 6587 8 halted halt VBN cord-023095-4dannjjm 6587 9 early early RB cord-023095-4dannjjm 6587 10 ( ( -LRB- cord-023095-4dannjjm 6587 11 6 6 CD cord-023095-4dannjjm 6587 12 min-9 min-9 NN cord-023095-4dannjjm 6587 13 min min NN cord-023095-4dannjjm 6587 14 ) ) -RRB- cord-023095-4dannjjm 6587 15 because because IN cord-023095-4dannjjm 6587 16 of of IN cord-023095-4dannjjm 6587 17 altered alter VBN cord-023095-4dannjjm 6587 18 gait gait NN cord-023095-4dannjjm 6587 19 or or CC cord-023095-4dannjjm 6587 20 mentation mentation NN cord-023095-4dannjjm 6587 21 . . . cord-023095-4dannjjm 6588 1 All all DT cord-023095-4dannjjm 6588 2 7 7 CD cord-023095-4dannjjm 6588 3 of of IN cord-023095-4dannjjm 6588 4 the the DT cord-023095-4dannjjm 6588 5 affected affect VBN cord-023095-4dannjjm 6588 6 dogs dog NNS cord-023095-4dannjjm 6588 7 were be VBD cord-023095-4dannjjm 6588 8 abnormal abnormal JJ cord-023095-4dannjjm 6588 9 in in IN cord-023095-4dannjjm 6588 10 the the DT cord-023095-4dannjjm 6588 11 15 15 CD cord-023095-4dannjjm 6588 12 minutes minute NNS cord-023095-4dannjjm 6588 13 following follow VBG cord-023095-4dannjjm 6588 14 exercise exercise NN cord-023095-4dannjjm 6588 15 . . . cord-023095-4dannjjm 6589 1 Abnormalities abnormality NNS cord-023095-4dannjjm 6589 2 seen see VBN cord-023095-4dannjjm 6589 3 in in IN cord-023095-4dannjjm 6589 4 all all DT cord-023095-4dannjjm 6589 5 dogs dog NNS cord-023095-4dannjjm 6589 6 included include VBD cord-023095-4dannjjm 6589 7 disorientation disorientation NN cord-023095-4dannjjm 6589 8 , , , cord-023095-4dannjjm 6589 9 dull dull JJ cord-023095-4dannjjm 6589 10 mentation mentation NN cord-023095-4dannjjm 6589 11 , , , cord-023095-4dannjjm 6589 12 swaying sway VBG cord-023095-4dannjjm 6589 13 , , , cord-023095-4dannjjm 6589 14 falling fall VBG cord-023095-4dannjjm 6589 15 to to IN cord-023095-4dannjjm 6589 16 the the DT cord-023095-4dannjjm 6589 17 side side NN cord-023095-4dannjjm 6589 18 , , , cord-023095-4dannjjm 6589 19 exaggerated exaggerated JJ cord-023095-4dannjjm 6589 20 lifting lifting NN cord-023095-4dannjjm 6589 21 of of IN cord-023095-4dannjjm 6589 22 limbs limb NNS cord-023095-4dannjjm 6589 23 each each DT cord-023095-4dannjjm 6589 24 step step NN cord-023095-4dannjjm 6589 25 , , , cord-023095-4dannjjm 6589 26 choppy choppy JJ cord-023095-4dannjjm 6589 27 gait gait NN cord-023095-4dannjjm 6589 28 , , , cord-023095-4dannjjm 6589 29 delayed delay VBN cord-023095-4dannjjm 6589 30 limb limb NN cord-023095-4dannjjm 6589 31 protraction protraction NN cord-023095-4dannjjm 6589 32 , , , cord-023095-4dannjjm 6589 33 scuffing scuffing NN cord-023095-4dannjjm 6589 34 of of IN cord-023095-4dannjjm 6589 35 rear rear NN cord-023095-4dannjjm 6589 36 and/or and/or CC cord-023095-4dannjjm 6589 37 forelegs foreleg NNS cord-023095-4dannjjm 6589 38 , , , cord-023095-4dannjjm 6589 39 and and CC cord-023095-4dannjjm 6589 40 crossing crossing NN cord-023095-4dannjjm 6589 41 legs leg NNS cord-023095-4dannjjm 6589 42 when when WRB cord-023095-4dannjjm 6589 43 turning turn VBG cord-023095-4dannjjm 6589 44 . . . cord-023095-4dannjjm 6590 1 All all DT cord-023095-4dannjjm 6590 2 dogs dog NNS cord-023095-4dannjjm 6590 3 returned return VBD cord-023095-4dannjjm 6590 4 to to IN cord-023095-4dannjjm 6590 5 normal normal JJ cord-023095-4dannjjm 6590 6 by by IN cord-023095-4dannjjm 6590 7 30 30 CD cord-023095-4dannjjm 6590 8 minutes minute NNS cord-023095-4dannjjm 6590 9 . . . cord-023095-4dannjjm 6591 1 BCC BCC NNP cord-023095-4dannjjm 6591 2 appears appear VBZ cord-023095-4dannjjm 6591 3 to to TO cord-023095-4dannjjm 6591 4 be be VB cord-023095-4dannjjm 6591 5 an an DT cord-023095-4dannjjm 6591 6 episodic episodic JJ cord-023095-4dannjjm 6591 7 nervous nervous JJ cord-023095-4dannjjm 6591 8 system system NN cord-023095-4dannjjm 6591 9 disorder disorder NN cord-023095-4dannjjm 6591 10 that that WDT cord-023095-4dannjjm 6591 11 can can MD cord-023095-4dannjjm 6591 12 be be VB cord-023095-4dannjjm 6591 13 triggered trigger VBN cord-023095-4dannjjm 6591 14 by by IN cord-023095-4dannjjm 6591 15 exercise exercise NN cord-023095-4dannjjm 6591 16 . . . cord-023095-4dannjjm 6592 1 Genetic genetic JJ cord-023095-4dannjjm 6592 2 testing testing NN cord-023095-4dannjjm 6592 3 excluded exclude VBD cord-023095-4dannjjm 6592 4 dEIC deic NN cord-023095-4dannjjm 6592 5 and and CC cord-023095-4dannjjm 6592 6 the the DT cord-023095-4dannjjm 6592 7 described describe VBN cord-023095-4dannjjm 6592 8 canine canine NN cord-023095-4dannjjm 6592 9 MH MH NNP cord-023095-4dannjjm 6592 10 mutation mutation NN cord-023095-4dannjjm 6592 11 . . . cord-023095-4dannjjm 6593 1 Common common JJ cord-023095-4dannjjm 6593 2 causes cause NNS cord-023095-4dannjjm 6593 3 of of IN cord-023095-4dannjjm 6593 4 exercise exercise NN cord-023095-4dannjjm 6593 5 intolerance intolerance NN cord-023095-4dannjjm 6593 6 were be VBD cord-023095-4dannjjm 6593 7 eliminated eliminate VBN cord-023095-4dannjjm 6593 8 , , , cord-023095-4dannjjm 6593 9 but but CC cord-023095-4dannjjm 6593 10 the the DT cord-023095-4dannjjm 6593 11 cause cause NN cord-023095-4dannjjm 6593 12 of of IN cord-023095-4dannjjm 6593 13 collapse collapse NN cord-023095-4dannjjm 6593 14 in in IN cord-023095-4dannjjm 6593 15 BCC BCC NNP cord-023095-4dannjjm 6593 16 was be VBD cord-023095-4dannjjm 6593 17 not not RB cord-023095-4dannjjm 6593 18 determined determine VBN cord-023095-4dannjjm 6593 19 and and CC cord-023095-4dannjjm 6593 20 no no DT cord-023095-4dannjjm 6593 21 clinical clinical JJ cord-023095-4dannjjm 6593 22 or or CC cord-023095-4dannjjm 6593 23 biochemical biochemical JJ cord-023095-4dannjjm 6593 24 marker marker NN cord-023095-4dannjjm 6593 25 to to TO cord-023095-4dannjjm 6593 26 aid aid VB cord-023095-4dannjjm 6593 27 diagnosis diagnosis NN cord-023095-4dannjjm 6593 28 was be VBD cord-023095-4dannjjm 6593 29 established establish VBN cord-023095-4dannjjm 6593 30 . . . cord-023095-4dannjjm 6594 1 Equine Equine NNP cord-023095-4dannjjm 6594 2 Cushing Cushing NNP cord-023095-4dannjjm 6594 3 's 's POS cord-023095-4dannjjm 6594 4 disease disease NN cord-023095-4dannjjm 6594 5 ( ( -LRB- cord-023095-4dannjjm 6594 6 ECD ECD NNP cord-023095-4dannjjm 6594 7 ) ) -RRB- cord-023095-4dannjjm 6594 8 is be VBZ cord-023095-4dannjjm 6594 9 common common JJ cord-023095-4dannjjm 6594 10 in in IN cord-023095-4dannjjm 6594 11 older old JJR cord-023095-4dannjjm 6594 12 horses horse NNS cord-023095-4dannjjm 6594 13 . . . cord-023095-4dannjjm 6595 1 The the DT cord-023095-4dannjjm 6595 2 purpose purpose NN cord-023095-4dannjjm 6595 3 of of IN cord-023095-4dannjjm 6595 4 this this DT cord-023095-4dannjjm 6595 5 study study NN cord-023095-4dannjjm 6595 6 was be VBD cord-023095-4dannjjm 6595 7 to to TO cord-023095-4dannjjm 6595 8 determine determine VB cord-023095-4dannjjm 6595 9 the the DT cord-023095-4dannjjm 6595 10 frequency frequency NN cord-023095-4dannjjm 6595 11 of of IN cord-023095-4dannjjm 6595 12 diagnosis diagnosis NN cord-023095-4dannjjm 6595 13 , , , cord-023095-4dannjjm 6595 14 identify identify VB cord-023095-4dannjjm 6595 15 prognostic prognostic JJ cord-023095-4dannjjm 6595 16 factors factor NNS cord-023095-4dannjjm 6595 17 and and CC cord-023095-4dannjjm 6595 18 assess assess VB cord-023095-4dannjjm 6595 19 owner owner NN cord-023095-4dannjjm 6595 20 satisfaction satisfaction NN cord-023095-4dannjjm 6595 21 with with IN cord-023095-4dannjjm 6595 22 treatment treatment NN cord-023095-4dannjjm 6595 23 . . . cord-023095-4dannjjm 6596 1 The the DT cord-023095-4dannjjm 6596 2 study study NN cord-023095-4dannjjm 6596 3 was be VBD cord-023095-4dannjjm 6596 4 a a DT cord-023095-4dannjjm 6596 5 retrospective retrospective JJ cord-023095-4dannjjm 6596 6 cohort cohort NN cord-023095-4dannjjm 6596 7 design design NN cord-023095-4dannjjm 6596 8 evaluating evaluate VBG cord-023095-4dannjjm 6596 9 equine equine JJ cord-023095-4dannjjm 6596 10 accessions accession NNS cord-023095-4dannjjm 6596 11 reported report VBN cord-023095-4dannjjm 6596 12 to to IN cord-023095-4dannjjm 6596 13 the the DT cord-023095-4dannjjm 6596 14 Veterinary Veterinary NNP cord-023095-4dannjjm 6596 15 Medical Medical NNP cord-023095-4dannjjm 6596 16 Data Data NNP cord-023095-4dannjjm 6596 17 Base Base NNP cord-023095-4dannjjm 6596 18 ( ( -LRB- cord-023095-4dannjjm 6596 19 VMDB VMDB NNP cord-023095-4dannjjm 6596 20 ) ) -RRB- cord-023095-4dannjjm 6596 21 and and CC cord-023095-4dannjjm 6596 22 the the DT cord-023095-4dannjjm 6596 23 Ohio Ohio NNP cord-023095-4dannjjm 6596 24 State State NNP cord-023095-4dannjjm 6596 25 University University NNP cord-023095-4dannjjm 6596 26 from from IN cord-023095-4dannjjm 6596 27 1993 1993 CD cord-023095-4dannjjm 6596 28 - - SYM cord-023095-4dannjjm 6596 29 2004 2004 CD cord-023095-4dannjjm 6596 30 . . . cord-023095-4dannjjm 6597 1 Proportional proportional JJ cord-023095-4dannjjm 6597 2 accessions accession NNS cord-023095-4dannjjm 6597 3 , , , cord-023095-4dannjjm 6597 4 annual annual JJ cord-023095-4dannjjm 6597 5 incidence incidence NN cord-023095-4dannjjm 6597 6 and and CC cord-023095-4dannjjm 6597 7 demographic demographic JJ cord-023095-4dannjjm 6597 8 characteristics characteristic NNS cord-023095-4dannjjm 6597 9 of of IN cord-023095-4dannjjm 6597 10 horses horse NNS cord-023095-4dannjjm 6597 11 with with IN cord-023095-4dannjjm 6597 12 ECD ECD NNP cord-023095-4dannjjm 6597 13 were be VBD cord-023095-4dannjjm 6597 14 compared compare VBN cord-023095-4dannjjm 6597 15 with with IN cord-023095-4dannjjm 6597 16 all all DT cord-023095-4dannjjm 6597 17 accessions accession NNS cord-023095-4dannjjm 6597 18 in in IN cord-023095-4dannjjm 6597 19 the the DT cord-023095-4dannjjm 6597 20 VMDB VMDB NNP cord-023095-4dannjjm 6597 21 . . . cord-023095-4dannjjm 6598 1 Medical medical JJ cord-023095-4dannjjm 6598 2 records record NNS cord-023095-4dannjjm 6598 3 for for IN cord-023095-4dannjjm 6598 4 a a DT cord-023095-4dannjjm 6598 5 subset subset NN cord-023095-4dannjjm 6598 6 of of IN cord-023095-4dannjjm 6598 7 horses horse NNS cord-023095-4dannjjm 6598 8 were be VBD cord-023095-4dannjjm 6598 9 extracted extract VBN cord-023095-4dannjjm 6598 10 and and CC cord-023095-4dannjjm 6598 11 owners owner NNS cord-023095-4dannjjm 6598 12 contacted contact VBD cord-023095-4dannjjm 6598 13 to to TO cord-023095-4dannjjm 6598 14 obtain obtain VB cord-023095-4dannjjm 6598 15 long long JJ cord-023095-4dannjjm 6598 16 - - HYPH cord-023095-4dannjjm 6598 17 term term NN cord-023095-4dannjjm 6598 18 follow follow VB cord-023095-4dannjjm 6598 19 up up RP cord-023095-4dannjjm 6598 20 information information NN cord-023095-4dannjjm 6598 21 . . . cord-023095-4dannjjm 6599 1 Two two CD cord-023095-4dannjjm 6599 2 hundred hundred CD cord-023095-4dannjjm 6599 3 seventeen seventeen CD cord-023095-4dannjjm 6599 4 new new JJ cord-023095-4dannjjm 6599 5 cases case NNS cord-023095-4dannjjm 6599 6 of of IN cord-023095-4dannjjm 6599 7 ECD ECD NNP cord-023095-4dannjjm 6599 8 were be VBD cord-023095-4dannjjm 6599 9 reported report VBN cord-023095-4dannjjm 6599 10 to to IN cord-023095-4dannjjm 6599 11 the the DT cord-023095-4dannjjm 6599 12 VMDB VMDB NNP cord-023095-4dannjjm 6599 13 . . . cord-023095-4dannjjm 6600 1 Incidence incidence NN cord-023095-4dannjjm 6600 2 increased increase VBD cord-023095-4dannjjm 6600 3 from from IN cord-023095-4dannjjm 6600 4 0.25/1,000 0.25/1,000 CD cord-023095-4dannjjm 6600 5 in in IN cord-023095-4dannjjm 6600 6 1993 1993 CD cord-023095-4dannjjm 6600 7 to to IN cord-023095-4dannjjm 6600 8 3.72/1,000 3.72/1,000 CD cord-023095-4dannjjm 6600 9 in in IN cord-023095-4dannjjm 6600 10 2002 2002 CD cord-023095-4dannjjm 6600 11 . . . cord-023095-4dannjjm 6601 1 Eighty eighty CD cord-023095-4dannjjm 6601 2 - - HYPH cord-023095-4dannjjm 6601 3 one one CD cord-023095-4dannjjm 6601 4 percent percent NN cord-023095-4dannjjm 6601 5 of of IN cord-023095-4dannjjm 6601 6 horses horse NNS cord-023095-4dannjjm 6601 7 were be VBD cord-023095-4dannjjm 6601 8 ! ! . cord-023095-4dannjjm 6602 1 15 15 CD cord-023095-4dannjjm 6602 2 years year NNS cord-023095-4dannjjm 6602 3 of of IN cord-023095-4dannjjm 6602 4 age age NN cord-023095-4dannjjm 6602 5 . . . cord-023095-4dannjjm 6603 1 Average average JJ cord-023095-4dannjjm 6603 2 delay delay NN cord-023095-4dannjjm 6603 3 from from IN cord-023095-4dannjjm 6603 4 onset onset NN cord-023095-4dannjjm 6603 5 of of IN cord-023095-4dannjjm 6603 6 signs sign NNS cord-023095-4dannjjm 6603 7 to to IN cord-023095-4dannjjm 6603 8 diagnosis diagnosis NN cord-023095-4dannjjm 6603 9 was be VBD cord-023095-4dannjjm 6603 10 180 180 CD cord-023095-4dannjjm 6603 11 days day NNS cord-023095-4dannjjm 6603 12 ( ( -LRB- cord-023095-4dannjjm 6603 13 range range VB cord-023095-4dannjjm 6603 14 1 1 CD cord-023095-4dannjjm 6603 15 to to IN cord-023095-4dannjjm 6603 16 1,824 1,824 CD cord-023095-4dannjjm 6603 17 days day NNS cord-023095-4dannjjm 6603 18 ) ) -RRB- cord-023095-4dannjjm 6603 19 . . . cord-023095-4dannjjm 6604 1 Hirsutism hirsutism NN cord-023095-4dannjjm 6604 2 ( ( -LRB- cord-023095-4dannjjm 6604 3 84 84 CD cord-023095-4dannjjm 6604 4 % % NN cord-023095-4dannjjm 6604 5 ) ) -RRB- cord-023095-4dannjjm 6604 6 and and CC cord-023095-4dannjjm 6604 7 laminitis laminitis NN cord-023095-4dannjjm 6604 8 ( ( -LRB- cord-023095-4dannjjm 6604 9 50 50 CD cord-023095-4dannjjm 6604 10 % % NN cord-023095-4dannjjm 6604 11 ) ) -RRB- cord-023095-4dannjjm 6604 12 were be VBD cord-023095-4dannjjm 6604 13 the the DT cord-023095-4dannjjm 6604 14 most most RBS cord-023095-4dannjjm 6604 15 common common JJ cord-023095-4dannjjm 6604 16 clinical clinical JJ cord-023095-4dannjjm 6604 17 signs sign NNS cord-023095-4dannjjm 6604 18 . . . cord-023095-4dannjjm 6605 1 Improvement improvement NN cord-023095-4dannjjm 6605 2 in in IN cord-023095-4dannjjm 6605 3 one one CD cord-023095-4dannjjm 6605 4 or or CC cord-023095-4dannjjm 6605 5 more more JJR cord-023095-4dannjjm 6605 6 signs sign NNS cord-023095-4dannjjm 6605 7 2 2 CD cord-023095-4dannjjm 6605 8 months month NNS cord-023095-4dannjjm 6605 9 after after IN cord-023095-4dannjjm 6605 10 diagnosis diagnosis NN cord-023095-4dannjjm 6605 11 was be VBD cord-023095-4dannjjm 6605 12 reported report VBN cord-023095-4dannjjm 6605 13 by by IN cord-023095-4dannjjm 6605 14 9/22 9/22 CD cord-023095-4dannjjm 6605 15 ( ( -LRB- cord-023095-4dannjjm 6605 16 41 41 CD cord-023095-4dannjjm 6605 17 % % NN cord-023095-4dannjjm 6605 18 ) ) -RRB- cord-023095-4dannjjm 6605 19 of of IN cord-023095-4dannjjm 6605 20 horse horse NN cord-023095-4dannjjm 6605 21 owners owner NNS cord-023095-4dannjjm 6605 22 . . . cord-023095-4dannjjm 6606 1 None none NN cord-023095-4dannjjm 6606 2 of of IN cord-023095-4dannjjm 6606 3 the the DT cord-023095-4dannjjm 6606 4 clinical clinical JJ cord-023095-4dannjjm 6606 5 or or CC cord-023095-4dannjjm 6606 6 laboratory laboratory NN cord-023095-4dannjjm 6606 7 data datum NNS cord-023095-4dannjjm 6606 8 were be VBD cord-023095-4dannjjm 6606 9 associated associate VBN cord-023095-4dannjjm 6606 10 with with IN cord-023095-4dannjjm 6606 11 survival survival NN cord-023095-4dannjjm 6606 12 and and CC cord-023095-4dannjjm 6606 13 , , , cord-023095-4dannjjm 6606 14 50 50 CD cord-023095-4dannjjm 6606 15 % % NN cord-023095-4dannjjm 6606 16 of of IN cord-023095-4dannjjm 6606 17 horses horse NNS cord-023095-4dannjjm 6606 18 were be VBD cord-023095-4dannjjm 6606 19 alive alive JJ cord-023095-4dannjjm 6606 20 , , , cord-023095-4dannjjm 6606 21 4.6 4.6 CD cord-023095-4dannjjm 6606 22 years year NNS cord-023095-4dannjjm 6606 23 after after IN cord-023095-4dannjjm 6606 24 diagnosis diagnosis NN cord-023095-4dannjjm 6606 25 . . . cord-023095-4dannjjm 6607 1 17/20 17/20 CD cord-023095-4dannjjm 6607 2 ( ( -LRB- cord-023095-4dannjjm 6607 3 85 85 CD cord-023095-4dannjjm 6607 4 % % NN cord-023095-4dannjjm 6607 5 ) ) -RRB- cord-023095-4dannjjm 6607 6 of of IN cord-023095-4dannjjm 6607 7 horses horse NNS cord-023095-4dannjjm 6607 8 were be VBD cord-023095-4dannjjm 6607 9 euthanatized euthanatize VBN cord-023095-4dannjjm 6607 10 and and CC cord-023095-4dannjjm 6607 11 13/17 13/17 CD cord-023095-4dannjjm 6607 12 ( ( -LRB- cord-023095-4dannjjm 6607 13 76 76 CD cord-023095-4dannjjm 6607 14 % % NN cord-023095-4dannjjm 6607 15 ) ) -RRB- cord-023095-4dannjjm 6607 16 were be VBD cord-023095-4dannjjm 6607 17 euthanatized euthanatize VBN cord-023095-4dannjjm 6607 18 due due IN cord-023095-4dannjjm 6607 19 to to IN cord-023095-4dannjjm 6607 20 conditions condition NNS cord-023095-4dannjjm 6607 21 associated associate VBN cord-023095-4dannjjm 6607 22 with with IN cord-023095-4dannjjm 6607 23 ECD ECD NNP cord-023095-4dannjjm 6607 24 . . . cord-023095-4dannjjm 6608 1 Twenty twenty CD cord-023095-4dannjjm 6608 2 - - HYPH cord-023095-4dannjjm 6608 3 eight eight CD cord-023095-4dannjjm 6608 4 of of IN cord-023095-4dannjjm 6608 5 29 29 CD cord-023095-4dannjjm 6608 6 ( ( -LRB- cord-023095-4dannjjm 6608 7 97 97 CD cord-023095-4dannjjm 6608 8 % % NN cord-023095-4dannjjm 6608 9 ) ) -RRB- cord-023095-4dannjjm 6608 10 of of IN cord-023095-4dannjjm 6608 11 horse horse NN cord-023095-4dannjjm 6608 12 owners owner NNS cord-023095-4dannjjm 6608 13 said say VBD cord-023095-4dannjjm 6608 14 they -PRON- PRP cord-023095-4dannjjm 6608 15 would would MD cord-023095-4dannjjm 6608 16 treat treat VB cord-023095-4dannjjm 6608 17 a a DT cord-023095-4dannjjm 6608 18 second second JJ cord-023095-4dannjjm 6608 19 horse horse NN cord-023095-4dannjjm 6608 20 for for IN cord-023095-4dannjjm 6608 21 ECD ECD NNP cord-023095-4dannjjm 6608 22 . . . cord-023095-4dannjjm 6609 1 ECD ECD NNP cord-023095-4dannjjm 6609 2 is be VBZ cord-023095-4dannjjm 6609 3 becoming become VBG cord-023095-4dannjjm 6609 4 a a DT cord-023095-4dannjjm 6609 5 more more RBR cord-023095-4dannjjm 6609 6 frequent frequent JJ cord-023095-4dannjjm 6609 7 diagnosis diagnosis NN cord-023095-4dannjjm 6609 8 . . . cord-023095-4dannjjm 6610 1 Fifty fifty CD cord-023095-4dannjjm 6610 2 percent percent NN cord-023095-4dannjjm 6610 3 of of IN cord-023095-4dannjjm 6610 4 horses horse NNS cord-023095-4dannjjm 6610 5 survived survive VBD cord-023095-4dannjjm 6610 6 4.5 4.5 CD cord-023095-4dannjjm 6610 7 years year NNS cord-023095-4dannjjm 6610 8 after after IN cord-023095-4dannjjm 6610 9 diagnosis diagnosis NN cord-023095-4dannjjm 6610 10 and and CC cord-023095-4dannjjm 6610 11 owners owner NNS cord-023095-4dannjjm 6610 12 were be VBD cord-023095-4dannjjm 6610 13 satisfied satisfied JJ cord-023095-4dannjjm 6610 14 with with IN cord-023095-4dannjjm 6610 15 the the DT cord-023095-4dannjjm 6610 16 horse horse NN cord-023095-4dannjjm 6610 17 's 's POS cord-023095-4dannjjm 6610 18 quality quality NN cord-023095-4dannjjm 6610 19 of of IN cord-023095-4dannjjm 6610 20 life life NN cord-023095-4dannjjm 6610 21 . . . cord-023095-4dannjjm 6611 1 Supported support VBN cord-023095-4dannjjm 6611 2 by by IN cord-023095-4dannjjm 6611 3 Centers Centers NNPS cord-023095-4dannjjm 6611 4 of of IN cord-023095-4dannjjm 6611 5 Excellence Excellence NNP cord-023095-4dannjjm 6611 6 in in IN cord-023095-4dannjjm 6611 7 Livestock Livestock NNP cord-023095-4dannjjm 6611 8 Diseases Diseases NNPS cord-023095-4dannjjm 6611 9 and and CC cord-023095-4dannjjm 6611 10 Human Human NNP cord-023095-4dannjjm 6611 11 Health Health NNP cord-023095-4dannjjm 6611 12 , , , cord-023095-4dannjjm 6611 13 College College NNP cord-023095-4dannjjm 6611 14 of of IN cord-023095-4dannjjm 6611 15 Veterinary Veterinary NNP cord-023095-4dannjjm 6611 16 Medicine Medicine NNP cord-023095-4dannjjm 6611 17 , , , cord-023095-4dannjjm 6611 18 University University NNP cord-023095-4dannjjm 6611 19 of of IN cord-023095-4dannjjm 6611 20 Tennessee Tennessee NNP cord-023095-4dannjjm 6611 21 . . . cord-023095-4dannjjm 6612 1 The the DT cord-023095-4dannjjm 6612 2 role role NN cord-023095-4dannjjm 6612 3 of of IN cord-023095-4dannjjm 6612 4 the the DT cord-023095-4dannjjm 6612 5 hypothalamic hypothalamic JJ cord-023095-4dannjjm 6612 6 - - HYPH cord-023095-4dannjjm 6612 7 pituitary pituitary NN cord-023095-4dannjjm 6612 8 - - HYPH cord-023095-4dannjjm 6612 9 adrenal adrenal NN cord-023095-4dannjjm 6612 10 ( ( -LRB- cord-023095-4dannjjm 6612 11 HPA HPA NNP cord-023095-4dannjjm 6612 12 ) ) -RRB- cord-023095-4dannjjm 6612 13 axis axis NN cord-023095-4dannjjm 6612 14 in in IN cord-023095-4dannjjm 6612 15 sepsis sepsis NN cord-023095-4dannjjm 6612 16 has have VBZ cord-023095-4dannjjm 6612 17 been be VBN cord-023095-4dannjjm 6612 18 a a DT cord-023095-4dannjjm 6612 19 subject subject NN cord-023095-4dannjjm 6612 20 of of IN cord-023095-4dannjjm 6612 21 a a DT cord-023095-4dannjjm 6612 22 great great JJ cord-023095-4dannjjm 6612 23 deal deal NN cord-023095-4dannjjm 6612 24 of of IN cord-023095-4dannjjm 6612 25 research research NN cord-023095-4dannjjm 6612 26 . . . cord-023095-4dannjjm 6613 1 The the DT cord-023095-4dannjjm 6613 2 role role NN cord-023095-4dannjjm 6613 3 that that WDT cord-023095-4dannjjm 6613 4 the the DT cord-023095-4dannjjm 6613 5 somatogenic somatogenic NNP cord-023095-4dannjjm 6613 6 axis axis NN cord-023095-4dannjjm 6613 7 plays play VBZ cord-023095-4dannjjm 6613 8 in in IN cord-023095-4dannjjm 6613 9 sepsis sepsis NN cord-023095-4dannjjm 6613 10 is be VBZ cord-023095-4dannjjm 6613 11 less less RBR cord-023095-4dannjjm 6613 12 well well RB cord-023095-4dannjjm 6613 13 understood understand VBN cord-023095-4dannjjm 6613 14 and and CC cord-023095-4dannjjm 6613 15 how how WRB cord-023095-4dannjjm 6613 16 these these DT cord-023095-4dannjjm 6613 17 two two CD cord-023095-4dannjjm 6613 18 axes axis NNS cord-023095-4dannjjm 6613 19 interact interact VBP cord-023095-4dannjjm 6613 20 during during IN cord-023095-4dannjjm 6613 21 critical critical JJ cord-023095-4dannjjm 6613 22 illness illness NN cord-023095-4dannjjm 6613 23 is be VBZ cord-023095-4dannjjm 6613 24 not not RB cord-023095-4dannjjm 6613 25 clear clear JJ cord-023095-4dannjjm 6613 26 . . . cord-023095-4dannjjm 6614 1 The the DT cord-023095-4dannjjm 6614 2 purpose purpose NN cord-023095-4dannjjm 6614 3 of of IN cord-023095-4dannjjm 6614 4 this this DT cord-023095-4dannjjm 6614 5 study study NN cord-023095-4dannjjm 6614 6 was be VBD cord-023095-4dannjjm 6614 7 to to TO cord-023095-4dannjjm 6614 8 assess assess VB cord-023095-4dannjjm 6614 9 inter inter JJ cord-023095-4dannjjm 6614 10 - - NNS cord-023095-4dannjjm 6614 11 relationships relationship NNS cord-023095-4dannjjm 6614 12 of of IN cord-023095-4dannjjm 6614 13 adrenocorticotropin adrenocorticotropin NNP cord-023095-4dannjjm 6614 14 ( ( -LRB- cord-023095-4dannjjm 6614 15 ACTH ACTH NNP cord-023095-4dannjjm 6614 16 ) ) -RRB- cord-023095-4dannjjm 6614 17 , , , cord-023095-4dannjjm 6614 18 cortisol cortisol NN cord-023095-4dannjjm 6614 19 , , , cord-023095-4dannjjm 6614 20 and and CC cord-023095-4dannjjm 6614 21 insulin insulin NN cord-023095-4dannjjm 6614 22 - - HYPH cord-023095-4dannjjm 6614 23 like like JJ cord-023095-4dannjjm 6614 24 growth growth NN cord-023095-4dannjjm 6614 25 factor factor NN cord-023095-4dannjjm 6614 26 - - : cord-023095-4dannjjm 6614 27 I i NN cord-023095-4dannjjm 6614 28 ( ( -LRB- cord-023095-4dannjjm 6614 29 IGF IGF NNP cord-023095-4dannjjm 6614 30 - - HYPH cord-023095-4dannjjm 6614 31 I I NNP cord-023095-4dannjjm 6614 32 ) ) -RRB- cord-023095-4dannjjm 6614 33 , , , cord-023095-4dannjjm 6614 34 in in IN cord-023095-4dannjjm 6614 35 septic septic JJ cord-023095-4dannjjm 6614 36 and and CC cord-023095-4dannjjm 6614 37 non non JJ cord-023095-4dannjjm 6614 38 - - JJ cord-023095-4dannjjm 6614 39 septic septic JJ cord-023095-4dannjjm 6614 40 term term NN cord-023095-4dannjjm 6614 41 foals foal NNS cord-023095-4dannjjm 6614 42 . . . cord-023095-4dannjjm 6615 1 Blood blood NN cord-023095-4dannjjm 6615 2 samples sample NNS cord-023095-4dannjjm 6615 3 were be VBD cord-023095-4dannjjm 6615 4 obtained obtain VBN cord-023095-4dannjjm 6615 5 from from IN cord-023095-4dannjjm 6615 6 term term NN cord-023095-4dannjjm 6615 7 septic septic JJ cord-023095-4dannjjm 6615 8 foals foal NNS cord-023095-4dannjjm 6615 9 less less JJR cord-023095-4dannjjm 6615 10 than than IN cord-023095-4dannjjm 6615 11 7 7 CD cord-023095-4dannjjm 6615 12 days day NNS cord-023095-4dannjjm 6615 13 of of IN cord-023095-4dannjjm 6615 14 age age NN cord-023095-4dannjjm 6615 15 ( ( -LRB- cord-023095-4dannjjm 6615 16 n n NN cord-023095-4dannjjm 6615 17 5 5 CD cord-023095-4dannjjm 6615 18 20 20 CD cord-023095-4dannjjm 6615 19 ) ) -RRB- cord-023095-4dannjjm 6615 20 admitted admit VBD cord-023095-4dannjjm 6615 21 to to IN cord-023095-4dannjjm 6615 22 Texas Texas NNP cord-023095-4dannjjm 6615 23 A&M A&M NNP cord-023095-4dannjjm 6615 24 University University NNP cord-023095-4dannjjm 6615 25 Veterinary Veterinary NNP cord-023095-4dannjjm 6615 26 Medical Medical NNP cord-023095-4dannjjm 6615 27 Teaching Teaching NNP cord-023095-4dannjjm 6615 28 Hospital Hospital NNP cord-023095-4dannjjm 6615 29 or or CC cord-023095-4dannjjm 6615 30 Mid Mid NNP cord-023095-4dannjjm 6615 31 - - NNP cord-023095-4dannjjm 6615 32 Atlantic Atlantic NNP cord-023095-4dannjjm 6615 33 Equine Equine NNP cord-023095-4dannjjm 6615 34 Hospital Hospital NNP cord-023095-4dannjjm 6615 35 . . . cord-023095-4dannjjm 6616 1 The the DT cord-023095-4dannjjm 6616 2 foals foal NNS cord-023095-4dannjjm 6616 3 were be VBD cord-023095-4dannjjm 6616 4 classified classify VBN cord-023095-4dannjjm 6616 5 as as IN cord-023095-4dannjjm 6616 6 septic septic JJ cord-023095-4dannjjm 6616 7 by by IN cord-023095-4dannjjm 6616 8 a a DT cord-023095-4dannjjm 6616 9 sepsis sepsis NN cord-023095-4dannjjm 6616 10 score score NN cord-023095-4dannjjm 6616 11 ! ! . cord-023095-4dannjjm 6617 1 11 11 CD cord-023095-4dannjjm 6618 1 and/ and/ NNP cord-023095-4dannjjm 6618 2 or or CC cord-023095-4dannjjm 6618 3 a a DT cord-023095-4dannjjm 6618 4 positive positive JJ cord-023095-4dannjjm 6618 5 blood blood NN cord-023095-4dannjjm 6618 6 culture culture NN cord-023095-4dannjjm 6618 7 . . . cord-023095-4dannjjm 6619 1 Non non JJ cord-023095-4dannjjm 6619 2 - - JJ cord-023095-4dannjjm 6619 3 septic septic JJ cord-023095-4dannjjm 6619 4 term term NN cord-023095-4dannjjm 6619 5 foals foal NNS cord-023095-4dannjjm 6619 6 less less JJR cord-023095-4dannjjm 6619 7 than than IN cord-023095-4dannjjm 6619 8 7 7 CD cord-023095-4dannjjm 6619 9 days day NNS cord-023095-4dannjjm 6619 10 of of IN cord-023095-4dannjjm 6619 11 age age NN cord-023095-4dannjjm 6619 12 ( ( -LRB- cord-023095-4dannjjm 6619 13 n n NN cord-023095-4dannjjm 6619 14 5 5 CD cord-023095-4dannjjm 6619 15 8) 8) NNP cord-023095-4dannjjm 6619 16 and and CC cord-023095-4dannjjm 6619 17 having have VBG cord-023095-4dannjjm 6619 18 a a DT cord-023095-4dannjjm 6619 19 sepsis sepsis NN cord-023095-4dannjjm 6619 20 score score NN cord-023095-4dannjjm 6619 21 o o NN cord-023095-4dannjjm 6619 22 11 11 CD cord-023095-4dannjjm 6619 23 and and CC cord-023095-4dannjjm 6619 24 a a DT cord-023095-4dannjjm 6619 25 negative negative JJ cord-023095-4dannjjm 6619 26 blood blood NN cord-023095-4dannjjm 6619 27 culture culture NN cord-023095-4dannjjm 6619 28 , , , cord-023095-4dannjjm 6619 29 were be VBD cord-023095-4dannjjm 6619 30 obtained obtain VBN cord-023095-4dannjjm 6619 31 from from IN cord-023095-4dannjjm 6619 32 Texas Texas NNP cord-023095-4dannjjm 6619 33 A&M A&M NNP cord-023095-4dannjjm 6619 34 University University NNP cord-023095-4dannjjm 6619 35 Veterinary Veterinary NNP cord-023095-4dannjjm 6619 36 Medical Medical NNP cord-023095-4dannjjm 6619 37 Teaching Teaching NNP cord-023095-4dannjjm 6619 38 Hospital Hospital NNP cord-023095-4dannjjm 6619 39 and and CC cord-023095-4dannjjm 6619 40 Mid Mid NNP cord-023095-4dannjjm 6619 41 - - NNP cord-023095-4dannjjm 6619 42 Atlantic Atlantic NNP cord-023095-4dannjjm 6619 43 Equine Equine NNP cord-023095-4dannjjm 6619 44 Hospital Hospital NNP cord-023095-4dannjjm 6619 45 . . . cord-023095-4dannjjm 6620 1 Plasma plasma NN cord-023095-4dannjjm 6620 2 and and CC cord-023095-4dannjjm 6620 3 serum serum NN cord-023095-4dannjjm 6620 4 were be VBD cord-023095-4dannjjm 6620 5 processed process VBN cord-023095-4dannjjm 6620 6 from from IN cord-023095-4dannjjm 6620 7 whole whole JJ cord-023095-4dannjjm 6620 8 blood blood NN cord-023095-4dannjjm 6620 9 collected collect VBN cord-023095-4dannjjm 6620 10 by by IN cord-023095-4dannjjm 6620 11 jugular jugular NN cord-023095-4dannjjm 6620 12 venipuncture venipuncture NN cord-023095-4dannjjm 6620 13 upon upon IN cord-023095-4dannjjm 6620 14 admission admission NN cord-023095-4dannjjm 6620 15 , , , cord-023095-4dannjjm 6620 16 at at IN cord-023095-4dannjjm 6620 17 24 24 CD cord-023095-4dannjjm 6620 18 hours hour NNS cord-023095-4dannjjm 6620 19 post post NN cord-023095-4dannjjm 6620 20 admission admission NN cord-023095-4dannjjm 6620 21 and and CC cord-023095-4dannjjm 6620 22 at at IN cord-023095-4dannjjm 6620 23 5 5 CD cord-023095-4dannjjm 6620 24 days day NNS cord-023095-4dannjjm 6620 25 post post NN cord-023095-4dannjjm 6620 26 admission admission NN cord-023095-4dannjjm 6620 27 or or CC cord-023095-4dannjjm 6620 28 at at IN cord-023095-4dannjjm 6620 29 the the DT cord-023095-4dannjjm 6620 30 time time NN cord-023095-4dannjjm 6620 31 of of IN cord-023095-4dannjjm 6620 32 discharge discharge NN cord-023095-4dannjjm 6620 33 . . . cord-023095-4dannjjm 6621 1 Plasma plasma NN cord-023095-4dannjjm 6621 2 concentrations concentration NNS cord-023095-4dannjjm 6621 3 of of IN cord-023095-4dannjjm 6621 4 ACTH ACTH NNP cord-023095-4dannjjm 6621 5 , , , cord-023095-4dannjjm 6621 6 and and CC cord-023095-4dannjjm 6621 7 serum serum NN cord-023095-4dannjjm 6621 8 concentrations concentration NNS cord-023095-4dannjjm 6621 9 of of IN cord-023095-4dannjjm 6621 10 cortisol cortisol NN cord-023095-4dannjjm 6621 11 and and CC cord-023095-4dannjjm 6621 12 IGF IGF NNP cord-023095-4dannjjm 6621 13 - - : cord-023095-4dannjjm 6621 14 I -PRON- PRP cord-023095-4dannjjm 6621 15 were be VBD cord-023095-4dannjjm 6621 16 determined determine VBN cord-023095-4dannjjm 6621 17 by by IN cord-023095-4dannjjm 6621 18 specific specific JJ cord-023095-4dannjjm 6621 19 RIAs ria NNS cord-023095-4dannjjm 6621 20 . . . cord-023095-4dannjjm 6622 1 Data datum NNS cord-023095-4dannjjm 6622 2 were be VBD cord-023095-4dannjjm 6622 3 analyzed analyze VBN cord-023095-4dannjjm 6622 4 using use VBG cord-023095-4dannjjm 6622 5 linear linear JJ cord-023095-4dannjjm 6622 6 mixed mix VBN cord-023095-4dannjjm 6622 7 - - HYPH cord-023095-4dannjjm 6622 8 effects effect NNS cord-023095-4dannjjm 6622 9 modeling modeling NN cord-023095-4dannjjm 6622 10 with with IN cord-023095-4dannjjm 6622 11 foal foal NN cord-023095-4dannjjm 6622 12 modeled model VBN cord-023095-4dannjjm 6622 13 as as IN cord-023095-4dannjjm 6622 14 a a DT cord-023095-4dannjjm 6622 15 random random JJ cord-023095-4dannjjm 6622 16 effect effect NN cord-023095-4dannjjm 6622 17 and and CC cord-023095-4dannjjm 6622 18 day day NN cord-023095-4dannjjm 6622 19 of of IN cord-023095-4dannjjm 6622 20 admission admission NN cord-023095-4dannjjm 6622 21 modeled model VBN cord-023095-4dannjjm 6622 22 as as IN cord-023095-4dannjjm 6622 23 an an DT cord-023095-4dannjjm 6622 24 ordered order VBN cord-023095-4dannjjm 6622 25 categorical categorical JJ cord-023095-4dannjjm 6622 26 variable variable NN cord-023095-4dannjjm 6622 27 ; ; : cord-023095-4dannjjm 6622 28 post post JJ cord-023095-4dannjjm 6622 29 - - JJ cord-023095-4dannjjm 6622 30 hoc hoc JJ cord-023095-4dannjjm 6622 31 testing testing NN cord-023095-4dannjjm 6622 32 of of IN cord-023095-4dannjjm 6622 33 pair pair NN cord-023095-4dannjjm 6622 34 - - HYPH cord-023095-4dannjjm 6622 35 wise wise JJ cord-023095-4dannjjm 6622 36 comparisons comparison NNS cord-023095-4dannjjm 6622 37 was be VBD cord-023095-4dannjjm 6622 38 made make VBN cord-023095-4dannjjm 6622 39 using use VBG cord-023095-4dannjjm 6622 40 the the DT cord-023095-4dannjjm 6622 41 method method NN cord-023095-4dannjjm 6622 42 of of IN cord-023095-4dannjjm 6622 43 Sidak Sidak NNP cord-023095-4dannjjm 6622 44 . . . cord-023095-4dannjjm 6623 1 Significance significance NN cord-023095-4dannjjm 6623 2 was be VBD cord-023095-4dannjjm 6623 3 set set VBN cord-023095-4dannjjm 6623 4 at at IN cord-023095-4dannjjm 6623 5 P p NN cord-023095-4dannjjm 6623 6 o o NN cord-023095-4dannjjm 6623 7 0.05 0.05 CD cord-023095-4dannjjm 6623 8 , , , cord-023095-4dannjjm 6623 9 and and CC cord-023095-4dannjjm 6623 10 analyses analysis NNS cord-023095-4dannjjm 6623 11 were be VBD cord-023095-4dannjjm 6623 12 performed perform VBN cord-023095-4dannjjm 6623 13 using use VBG cord-023095-4dannjjm 6623 14 S S NNP cord-023095-4dannjjm 6623 15 - - HYPH cord-023095-4dannjjm 6623 16 PLUS PLUS NNP cord-023095-4dannjjm 6623 17 software software NN cord-023095-4dannjjm 6623 18 ( ( -LRB- cord-023095-4dannjjm 6623 19 TIBCO TIBCO NNP cord-023095-4dannjjm 6623 20 , , , cord-023095-4dannjjm 6623 21 Inc. Inc. NNP cord-023095-4dannjjm 6623 22 , , , cord-023095-4dannjjm 6623 23 Seattle Seattle NNP cord-023095-4dannjjm 6623 24 , , , cord-023095-4dannjjm 6623 25 WA WA NNP cord-023095-4dannjjm 6623 26 ) ) -RRB- cord-023095-4dannjjm 6623 27 . . . cord-023095-4dannjjm 6624 1 Plasma plasma NN cord-023095-4dannjjm 6624 2 concentrations concentration NNS cord-023095-4dannjjm 6624 3 of of IN cord-023095-4dannjjm 6624 4 ACTH ACTH NNP cord-023095-4dannjjm 6624 5 were be VBD cord-023095-4dannjjm 6624 6 not not RB cord-023095-4dannjjm 6624 7 significantly significantly RB cord-023095-4dannjjm 6624 8 different different JJ cord-023095-4dannjjm 6624 9 between between IN cord-023095-4dannjjm 6624 10 septic septic JJ cord-023095-4dannjjm 6624 11 and and CC cord-023095-4dannjjm 6624 12 non non JJ cord-023095-4dannjjm 6624 13 - - JJ cord-023095-4dannjjm 6624 14 septic septic JJ cord-023095-4dannjjm 6624 15 foals foal NNS cord-023095-4dannjjm 6624 16 whereas whereas IN cord-023095-4dannjjm 6624 17 septic septic JJ cord-023095-4dannjjm 6624 18 foals foal NNS cord-023095-4dannjjm 6624 19 had have VBD cord-023095-4dannjjm 6624 20 greater great JJR cord-023095-4dannjjm 6624 21 serum serum NN cord-023095-4dannjjm 6624 22 cortisol cortisol NN cord-023095-4dannjjm 6624 23 ( ( -LRB- cord-023095-4dannjjm 6624 24 37 37 CD cord-023095-4dannjjm 6624 25 AE AE NNP cord-023095-4dannjjm 6624 26 8 8 CD cord-023095-4dannjjm 6624 27 ng ng NN cord-023095-4dannjjm 6624 28 / / SYM cord-023095-4dannjjm 6624 29 mL ml NN cord-023095-4dannjjm 6624 30 vs vs IN cord-023095-4dannjjm 6624 31 25 25 CD cord-023095-4dannjjm 6624 32 AE AE NNP cord-023095-4dannjjm 6624 33 7 7 CD cord-023095-4dannjjm 6624 34 ng ng NN cord-023095-4dannjjm 6624 35 / / SYM cord-023095-4dannjjm 6624 36 mL ml NN cord-023095-4dannjjm 6624 37 ) ) -RRB- cord-023095-4dannjjm 6624 38 but but CC cord-023095-4dannjjm 6624 39 lower low JJR cord-023095-4dannjjm 6624 40 serum serum NN cord-023095-4dannjjm 6624 41 IGF IGF NNP cord-023095-4dannjjm 6624 42 - - : cord-023095-4dannjjm 6624 43 I I NNP cord-023095-4dannjjm 6625 1 ( ( -LRB- cord-023095-4dannjjm 6625 2 116 116 CD cord-023095-4dannjjm 6625 3 AE AE NNP cord-023095-4dannjjm 6625 4 14 14 CD cord-023095-4dannjjm 6625 5 ng ng NN cord-023095-4dannjjm 6625 6 / / SYM cord-023095-4dannjjm 6625 7 mL ml NN cord-023095-4dannjjm 6625 8 vs vs IN cord-023095-4dannjjm 6625 9 152 152 CD cord-023095-4dannjjm 6625 10 AE AE NNP cord-023095-4dannjjm 6625 11 15 15 CD cord-023095-4dannjjm 6625 12 ng ng NN cord-023095-4dannjjm 6625 13 / / SYM cord-023095-4dannjjm 6625 14 mL ml NN cord-023095-4dannjjm 6626 1 ) ) -RRB- cord-023095-4dannjjm 6626 2 relative relative JJ cord-023095-4dannjjm 6626 3 to to IN cord-023095-4dannjjm 6626 4 non non JJ cord-023095-4dannjjm 6626 5 - - JJ cord-023095-4dannjjm 6626 6 septic septic JJ cord-023095-4dannjjm 6626 7 foals foal NNS cord-023095-4dannjjm 6626 8 pooled pool VBD cord-023095-4dannjjm 6626 9 overall overall JJ cord-023095-4dannjjm 6626 10 sampling sampling NN cord-023095-4dannjjm 6626 11 times time NNS cord-023095-4dannjjm 6626 12 . . . cord-023095-4dannjjm 6627 1 The the DT cord-023095-4dannjjm 6627 2 positive positive JJ cord-023095-4dannjjm 6627 3 association association NN cord-023095-4dannjjm 6627 4 of of IN cord-023095-4dannjjm 6627 5 the the DT cord-023095-4dannjjm 6627 6 peripheral peripheral JJ cord-023095-4dannjjm 6627 7 blood blood NN cord-023095-4dannjjm 6627 8 concentrations concentration NNS cord-023095-4dannjjm 6627 9 of of IN cord-023095-4dannjjm 6627 10 ACTH ACTH NNP cord-023095-4dannjjm 6627 11 and and CC cord-023095-4dannjjm 6627 12 cortisol cortisol NN cord-023095-4dannjjm 6627 13 depended depend VBD cord-023095-4dannjjm 6627 14 on on IN cord-023095-4dannjjm 6627 15 disease disease NN cord-023095-4dannjjm 6627 16 status status NN cord-023095-4dannjjm 6627 17 of of IN cord-023095-4dannjjm 6627 18 the the DT cord-023095-4dannjjm 6627 19 foals foal NNS cord-023095-4dannjjm 6627 20 . . . cord-023095-4dannjjm 6628 1 Specifically specifically RB cord-023095-4dannjjm 6628 2 , , , cord-023095-4dannjjm 6628 3 cortisol cortisol NN cord-023095-4dannjjm 6628 4 and and CC cord-023095-4dannjjm 6628 5 ACTH ACTH NNP cord-023095-4dannjjm 6628 6 were be VBD cord-023095-4dannjjm 6628 7 positively positively RB cord-023095-4dannjjm 6628 8 correlated correlate VBN cord-023095-4dannjjm 6628 9 for for IN cord-023095-4dannjjm 6628 10 the the DT cord-023095-4dannjjm 6628 11 septic septic JJ cord-023095-4dannjjm 6628 12 foals foal NNS cord-023095-4dannjjm 6628 13 ( ( -LRB- cord-023095-4dannjjm 6628 14 P p NN cord-023095-4dannjjm 6628 15 5 5 CD cord-023095-4dannjjm 6628 16 0.027 0.027 CD cord-023095-4dannjjm 6628 17 ) ) -RRB- cord-023095-4dannjjm 6628 18 but but CC cord-023095-4dannjjm 6628 19 not not RB cord-023095-4dannjjm 6628 20 significantly significantly RB cord-023095-4dannjjm 6628 21 correlated correlate VBN cord-023095-4dannjjm 6628 22 in in IN cord-023095-4dannjjm 6628 23 the the DT cord-023095-4dannjjm 6628 24 non non JJ cord-023095-4dannjjm 6628 25 - - JJ cord-023095-4dannjjm 6628 26 septic septic JJ cord-023095-4dannjjm 6628 27 foals foal NNS cord-023095-4dannjjm 6628 28 . . . cord-023095-4dannjjm 6629 1 Peripheral peripheral JJ cord-023095-4dannjjm 6629 2 concentrations concentration NNS cord-023095-4dannjjm 6629 3 of of IN cord-023095-4dannjjm 6629 4 ACTH ACTH NNP cord-023095-4dannjjm 6629 5 and and CC cord-023095-4dannjjm 6629 6 IGF IGF NNP cord-023095-4dannjjm 6629 7 - - : cord-023095-4dannjjm 6629 8 I -PRON- PRP cord-023095-4dannjjm 6629 9 were be VBD cord-023095-4dannjjm 6629 10 not not RB cord-023095-4dannjjm 6629 11 significantly significantly RB cord-023095-4dannjjm 6629 12 correlated correlate VBN cord-023095-4dannjjm 6629 13 whether whether IN cord-023095-4dannjjm 6629 14 data datum NNS cord-023095-4dannjjm 6629 15 were be VBD cord-023095-4dannjjm 6629 16 pooled pool VBN cord-023095-4dannjjm 6629 17 overall overall RB cord-023095-4dannjjm 6629 18 or or CC cord-023095-4dannjjm 6629 19 stratified stratify VBN cord-023095-4dannjjm 6629 20 by by IN cord-023095-4dannjjm 6629 21 sepsis sepsis NN cord-023095-4dannjjm 6629 22 status status NN cord-023095-4dannjjm 6629 23 . . . cord-023095-4dannjjm 6630 1 However however RB cord-023095-4dannjjm 6630 2 , , , cord-023095-4dannjjm 6630 3 peripheral peripheral JJ cord-023095-4dannjjm 6630 4 concentrations concentration NNS cord-023095-4dannjjm 6630 5 of of IN cord-023095-4dannjjm 6630 6 cortisol cortisol NN cord-023095-4dannjjm 6630 7 and and CC cord-023095-4dannjjm 6630 8 IGF IGF NNP cord-023095-4dannjjm 6630 9 - - : cord-023095-4dannjjm 6630 10 I -PRON- PRP cord-023095-4dannjjm 6630 11 were be VBD cord-023095-4dannjjm 6630 12 negatively negatively RB cord-023095-4dannjjm 6630 13 associated associate VBN cord-023095-4dannjjm 6630 14 ( ( -LRB- cord-023095-4dannjjm 6630 15 P p NN cord-023095-4dannjjm 6630 16 5 5 CD cord-023095-4dannjjm 6630 17 0.019 0.019 CD cord-023095-4dannjjm 6630 18 ) ) -RRB- cord-023095-4dannjjm 6630 19 ; ; : cord-023095-4dannjjm 6630 20 disease disease NN cord-023095-4dannjjm 6630 21 status status NN cord-023095-4dannjjm 6630 22 did do VBD cord-023095-4dannjjm 6630 23 not not RB cord-023095-4dannjjm 6630 24 influence influence VB cord-023095-4dannjjm 6630 25 this this DT cord-023095-4dannjjm 6630 26 association association NN cord-023095-4dannjjm 6630 27 , , , cord-023095-4dannjjm 6630 28 although although IN cord-023095-4dannjjm 6630 29 it -PRON- PRP cord-023095-4dannjjm 6630 30 appeared appear VBD cord-023095-4dannjjm 6630 31 to to TO cord-023095-4dannjjm 6630 32 be be VB cord-023095-4dannjjm 6630 33 a a DT cord-023095-4dannjjm 6630 34 stronger strong JJR cord-023095-4dannjjm 6630 35 association association NN cord-023095-4dannjjm 6630 36 for for IN cord-023095-4dannjjm 6630 37 the the DT cord-023095-4dannjjm 6630 38 septic septic NN cord-023095-4dannjjm 6630 39 than than IN cord-023095-4dannjjm 6630 40 the the DT cord-023095-4dannjjm 6630 41 non non JJ cord-023095-4dannjjm 6630 42 - - JJ cord-023095-4dannjjm 6630 43 septic septic JJ cord-023095-4dannjjm 6630 44 foals foal NNS cord-023095-4dannjjm 6630 45 . . . cord-023095-4dannjjm 6631 1 The the DT cord-023095-4dannjjm 6631 2 negative negative JJ cord-023095-4dannjjm 6631 3 correlation correlation NN cord-023095-4dannjjm 6631 4 between between IN cord-023095-4dannjjm 6631 5 serum serum NN cord-023095-4dannjjm 6631 6 concentrations concentration NNS cord-023095-4dannjjm 6631 7 of of IN cord-023095-4dannjjm 6631 8 the the DT cord-023095-4dannjjm 6631 9 adrenal adrenal JJ cord-023095-4dannjjm 6631 10 axis axis NN cord-023095-4dannjjm 6631 11 steroid steroid NN cord-023095-4dannjjm 6631 12 cortisol cortisol NN cord-023095-4dannjjm 6631 13 and and CC cord-023095-4dannjjm 6631 14 the the DT cord-023095-4dannjjm 6631 15 somatogenic somatogenic NNP cord-023095-4dannjjm 6631 16 axis axis NN cord-023095-4dannjjm 6631 17 peptide peptide NN cord-023095-4dannjjm 6631 18 IGF IGF NNP cord-023095-4dannjjm 6631 19 - - : cord-023095-4dannjjm 6631 20 I -PRON- PRP cord-023095-4dannjjm 6631 21 may may MD cord-023095-4dannjjm 6631 22 reflect reflect VB cord-023095-4dannjjm 6631 23 interactions interaction NNS cord-023095-4dannjjm 6631 24 of of IN cord-023095-4dannjjm 6631 25 these these DT cord-023095-4dannjjm 6631 26 homeorhetic homeorhetic JJ cord-023095-4dannjjm 6631 27 hormones hormone NNS cord-023095-4dannjjm 6631 28 . . . cord-023095-4dannjjm 6632 1 Further further JJ cord-023095-4dannjjm 6632 2 studies study NNS cord-023095-4dannjjm 6632 3 of of IN cord-023095-4dannjjm 6632 4 these these DT cord-023095-4dannjjm 6632 5 and and CC cord-023095-4dannjjm 6632 6 other other JJ cord-023095-4dannjjm 6632 7 metabolic metabolic JJ cord-023095-4dannjjm 6632 8 hormones hormone NNS cord-023095-4dannjjm 6632 9 in in IN cord-023095-4dannjjm 6632 10 a a DT cord-023095-4dannjjm 6632 11 greater great JJR cord-023095-4dannjjm 6632 12 number number NN cord-023095-4dannjjm 6632 13 of of IN cord-023095-4dannjjm 6632 14 foals foal NNS cord-023095-4dannjjm 6632 15 are be VBP cord-023095-4dannjjm 6632 16 warranted warrant VBN cord-023095-4dannjjm 6632 17 to to TO cord-023095-4dannjjm 6632 18 better well RBR cord-023095-4dannjjm 6632 19 understand understand VB cord-023095-4dannjjm 6632 20 how how WRB cord-023095-4dannjjm 6632 21 these these DT cord-023095-4dannjjm 6632 22 factors factor NNS cord-023095-4dannjjm 6632 23 contribute contribute VBP cord-023095-4dannjjm 6632 24 to to IN cord-023095-4dannjjm 6632 25 survival survival NN cord-023095-4dannjjm 6632 26 or or CC cord-023095-4dannjjm 6632 27 non non JJ cord-023095-4dannjjm 6632 28 - - JJ cord-023095-4dannjjm 6632 29 survival survival NN cord-023095-4dannjjm 6632 30 of of IN cord-023095-4dannjjm 6632 31 critically critically RB cord-023095-4dannjjm 6632 32 ill ill JJ cord-023095-4dannjjm 6632 33 foals foal NNS cord-023095-4dannjjm 6632 34 . . . cord-023095-4dannjjm 6633 1 Botulism botulism NN cord-023095-4dannjjm 6633 2 is be VBZ cord-023095-4dannjjm 6633 3 a a DT cord-023095-4dannjjm 6633 4 potentially potentially RB cord-023095-4dannjjm 6633 5 fatal fatal JJ cord-023095-4dannjjm 6633 6 paralytic paralytic JJ cord-023095-4dannjjm 6633 7 disorder disorder NN cord-023095-4dannjjm 6633 8 which which WDT cord-023095-4dannjjm 6633 9 definitive definitive JJ cord-023095-4dannjjm 6633 10 diagnosis diagnosis NN cord-023095-4dannjjm 6633 11 is be VBZ cord-023095-4dannjjm 6633 12 difficult difficult JJ cord-023095-4dannjjm 6633 13 . . . cord-023095-4dannjjm 6634 1 The the DT cord-023095-4dannjjm 6634 2 purpose purpose NN cord-023095-4dannjjm 6634 3 of of IN cord-023095-4dannjjm 6634 4 this this DT cord-023095-4dannjjm 6634 5 study study NN cord-023095-4dannjjm 6634 6 was be VBD cord-023095-4dannjjm 6634 7 to to TO cord-023095-4dannjjm 6634 8 investigate investigate VB cord-023095-4dannjjm 6634 9 if if IN cord-023095-4dannjjm 6634 10 repetitive repetitive JJ cord-023095-4dannjjm 6634 11 stimulation stimulation NN cord-023095-4dannjjm 6634 12 of of IN cord-023095-4dannjjm 6634 13 the the DT cord-023095-4dannjjm 6634 14 common common JJ cord-023095-4dannjjm 6634 15 peroneal peroneal NN cord-023095-4dannjjm 6634 16 nerve nerve NN cord-023095-4dannjjm 6634 17 will will MD cord-023095-4dannjjm 6634 18 aid aid VB cord-023095-4dannjjm 6634 19 in in IN cord-023095-4dannjjm 6634 20 the the DT cord-023095-4dannjjm 6634 21 diagnosis diagnosis NN cord-023095-4dannjjm 6634 22 of of IN cord-023095-4dannjjm 6634 23 suspected suspect VBN cord-023095-4dannjjm 6634 24 botulism botulism NN cord-023095-4dannjjm 6634 25 in in IN cord-023095-4dannjjm 6634 26 foals foal NNS cord-023095-4dannjjm 6634 27 . . . cord-023095-4dannjjm 6635 1 Four four CD cord-023095-4dannjjm 6635 2 healthy healthy JJ cord-023095-4dannjjm 6635 3 foals foal NNS cord-023095-4dannjjm 6635 4 were be VBD cord-023095-4dannjjm 6635 5 used use VBN cord-023095-4dannjjm 6635 6 for for IN cord-023095-4dannjjm 6635 7 its -PRON- PRP$ cord-023095-4dannjjm 6635 8 comparison comparison NN cord-023095-4dannjjm 6635 9 with with IN cord-023095-4dannjjm 6635 10 3 3 CD cord-023095-4dannjjm 6635 11 foals foal NNS cord-023095-4dannjjm 6635 12 with with IN cord-023095-4dannjjm 6635 13 suspected suspect VBN cord-023095-4dannjjm 6635 14 botulism botulism NN cord-023095-4dannjjm 6635 15 . . . cord-023095-4dannjjm 6636 1 Controls control NNS cord-023095-4dannjjm 6636 2 were be VBD cord-023095-4dannjjm 6636 3 anesthetized anesthetize VBN cord-023095-4dannjjm 6636 4 and and CC cord-023095-4dannjjm 6636 5 affected affect VBN cord-023095-4dannjjm 6636 6 foals foal NNS cord-023095-4dannjjm 6636 7 were be VBD cord-023095-4dannjjm 6636 8 sedated sedate VBN cord-023095-4dannjjm 6636 9 to to TO cord-023095-4dannjjm 6636 10 avoid avoid VB cord-023095-4dannjjm 6636 11 risks risk NNS cord-023095-4dannjjm 6636 12 of of IN cord-023095-4dannjjm 6636 13 anesthesia anesthesia NN cord-023095-4dannjjm 6636 14 . . . cord-023095-4dannjjm 6637 1 The the DT cord-023095-4dannjjm 6637 2 common common JJ cord-023095-4dannjjm 6637 3 peroneal peroneal NN cord-023095-4dannjjm 6637 4 nerve nerve NN cord-023095-4dannjjm 6637 5 was be VBD cord-023095-4dannjjm 6637 6 chosen choose VBN cord-023095-4dannjjm 6637 7 for for IN cord-023095-4dannjjm 6637 8 its -PRON- PRP$ cord-023095-4dannjjm 6637 9 superficial superficial JJ cord-023095-4dannjjm 6637 10 location location NN cord-023095-4dannjjm 6637 11 and and CC cord-023095-4dannjjm 6637 12 easy easy JJ cord-023095-4dannjjm 6637 13 access access NN cord-023095-4dannjjm 6637 14 . . . cord-023095-4dannjjm 6638 1 Stimulating stimulating JJ cord-023095-4dannjjm 6638 2 electrodes electrode NNS cord-023095-4dannjjm 6638 3 were be VBD cord-023095-4dannjjm 6638 4 placed place VBN cord-023095-4dannjjm 6638 5 along along IN cord-023095-4dannjjm 6638 6 the the DT cord-023095-4dannjjm 6638 7 common common JJ cord-023095-4dannjjm 6638 8 peroneal peroneal NN cord-023095-4dannjjm 6638 9 nerve nerve NN cord-023095-4dannjjm 6638 10 . . . cord-023095-4dannjjm 6639 1 For for IN cord-023095-4dannjjm 6639 2 recording record VBG cord-023095-4dannjjm 6639 3 , , , cord-023095-4dannjjm 6639 4 the the DT cord-023095-4dannjjm 6639 5 active active JJ cord-023095-4dannjjm 6639 6 and and CC cord-023095-4dannjjm 6639 7 reference reference NN cord-023095-4dannjjm 6639 8 electrodes electrode NNS cord-023095-4dannjjm 6639 9 were be VBD cord-023095-4dannjjm 6639 10 positioned position VBN cord-023095-4dannjjm 6639 11 over over IN cord-023095-4dannjjm 6639 12 the the DT cord-023095-4dannjjm 6639 13 midpoint midpoint NN cord-023095-4dannjjm 6639 14 and and CC cord-023095-4dannjjm 6639 15 distal distal JJ cord-023095-4dannjjm 6639 16 end end NN cord-023095-4dannjjm 6639 17 of of IN cord-023095-4dannjjm 6639 18 the the DT cord-023095-4dannjjm 6639 19 extensor extensor NN cord-023095-4dannjjm 6639 20 digitorum digitorum FW cord-023095-4dannjjm 6639 21 longus longus NN cord-023095-4dannjjm 6639 22 muscle muscle NN cord-023095-4dannjjm 6639 23 , , , cord-023095-4dannjjm 6639 24 respectively respectively RB cord-023095-4dannjjm 6639 25 . . . cord-023095-4dannjjm 6640 1 Repeated repeat VBN cord-023095-4dannjjm 6640 2 supramaximal supramaximal JJ cord-023095-4dannjjm 6640 3 stimulation stimulation NN cord-023095-4dannjjm 6640 4 of of IN cord-023095-4dannjjm 6640 5 the the DT cord-023095-4dannjjm 6640 6 nerve nerve NN cord-023095-4dannjjm 6640 7 was be VBD cord-023095-4dannjjm 6640 8 performed perform VBN cord-023095-4dannjjm 6640 9 utilizing utilize VBG cord-023095-4dannjjm 6640 10 a a DT cord-023095-4dannjjm 6640 11 range range NN cord-023095-4dannjjm 6640 12 of of IN cord-023095-4dannjjm 6640 13 frequencies frequency NNS cord-023095-4dannjjm 6640 14 ( ( -LRB- cord-023095-4dannjjm 6640 15 1 1 CD cord-023095-4dannjjm 6640 16 to to IN cord-023095-4dannjjm 6640 17 50 50 CD cord-023095-4dannjjm 6640 18 Hz Hz NNS cord-023095-4dannjjm 6640 19 ) ) -RRB- cord-023095-4dannjjm 6640 20 . . . cord-023095-4dannjjm 6641 1 Amplitude amplitude NN cord-023095-4dannjjm 6641 2 , , , cord-023095-4dannjjm 6641 3 area area NN cord-023095-4dannjjm 6641 4 under under IN cord-023095-4dannjjm 6641 5 the the DT cord-023095-4dannjjm 6641 6 curve curve NN cord-023095-4dannjjm 6641 7 and and CC cord-023095-4dannjjm 6641 8 percentages percentage NNS cord-023095-4dannjjm 6641 9 of of IN cord-023095-4dannjjm 6641 10 decrement decrement NN cord-023095-4dannjjm 6641 11 or or CC cord-023095-4dannjjm 6641 12 increment increment NN cord-023095-4dannjjm 6641 13 for for IN cord-023095-4dannjjm 6641 14 each each DT cord-023095-4dannjjm 6641 15 M m CD cord-023095-4dannjjm 6641 16 wave wave NN cord-023095-4dannjjm 6641 17 over over IN cord-023095-4dannjjm 6641 18 subsequent subsequent JJ cord-023095-4dannjjm 6641 19 potentials potential NNS cord-023095-4dannjjm 6641 20 for for IN cord-023095-4dannjjm 6641 21 each each DT cord-023095-4dannjjm 6641 22 set set NN cord-023095-4dannjjm 6641 23 of of IN cord-023095-4dannjjm 6641 24 stimuli stimulus NNS cord-023095-4dannjjm 6641 25 were be VBD cord-023095-4dannjjm 6641 26 analyzed analyze VBN cord-023095-4dannjjm 6641 27 . . . cord-023095-4dannjjm 6642 1 Baseline Baseline NNP cord-023095-4dannjjm 6642 2 M M NNP cord-023095-4dannjjm 6642 3 waves wave NNS cord-023095-4dannjjm 6642 4 were be VBD cord-023095-4dannjjm 6642 5 decreased decrease VBN cord-023095-4dannjjm 6642 6 in in IN cord-023095-4dannjjm 6642 7 affected affect VBN cord-023095-4dannjjm 6642 8 foals foal NNS cord-023095-4dannjjm 6642 9 compared compare VBN cord-023095-4dannjjm 6642 10 to to IN cord-023095-4dannjjm 6642 11 controls control NNS cord-023095-4dannjjm 6642 12 . . . cord-023095-4dannjjm 6643 1 A a DT cord-023095-4dannjjm 6643 2 decremental decremental JJ cord-023095-4dannjjm 6643 3 response response NN cord-023095-4dannjjm 6643 4 was be VBD cord-023095-4dannjjm 6643 5 seen see VBN cord-023095-4dannjjm 6643 6 at at IN cord-023095-4dannjjm 6643 7 all all DT cord-023095-4dannjjm 6643 8 frequencies frequency NNS cord-023095-4dannjjm 6643 9 in in IN cord-023095-4dannjjm 6643 10 control control NN cord-023095-4dannjjm 6643 11 foals foal NNS cord-023095-4dannjjm 6643 12 . . . cord-023095-4dannjjm 6644 1 Decremental Decremental NNP cord-023095-4dannjjm 6644 2 responses response NNS cord-023095-4dannjjm 6644 3 were be VBD cord-023095-4dannjjm 6644 4 also also RB cord-023095-4dannjjm 6644 5 observed observe VBN cord-023095-4dannjjm 6644 6 in in IN cord-023095-4dannjjm 6644 7 affected affected JJ cord-023095-4dannjjm 6644 8 foals foal NNS cord-023095-4dannjjm 6644 9 at at IN cord-023095-4dannjjm 6644 10 low low JJ cord-023095-4dannjjm 6644 11 frequencies frequency NNS cord-023095-4dannjjm 6644 12 . . . cord-023095-4dannjjm 6645 1 However however RB cord-023095-4dannjjm 6645 2 , , , cord-023095-4dannjjm 6645 3 an an DT cord-023095-4dannjjm 6645 4 incremental incremental JJ cord-023095-4dannjjm 6645 5 response response NN cord-023095-4dannjjm 6645 6 in in IN cord-023095-4dannjjm 6645 7 amplitude amplitude NN cord-023095-4dannjjm 6645 8 and and CC cord-023095-4dannjjm 6645 9 area area NN cord-023095-4dannjjm 6645 10 under under IN cord-023095-4dannjjm 6645 11 the the DT cord-023095-4dannjjm 6645 12 curve curve NN cord-023095-4dannjjm 6645 13 was be VBD cord-023095-4dannjjm 6645 14 seen see VBN cord-023095-4dannjjm 6645 15 in in IN cord-023095-4dannjjm 6645 16 all all DT cord-023095-4dannjjm 6645 17 affected affect VBN cord-023095-4dannjjm 6645 18 foals foal NNS cord-023095-4dannjjm 6645 19 at at IN cord-023095-4dannjjm 6645 20 50 50 CD cord-023095-4dannjjm 6645 21 Hz Hz NNS cord-023095-4dannjjm 6645 22 . . . cord-023095-4dannjjm 6646 1 Reduced reduce VBN cord-023095-4dannjjm 6646 2 baseline baseline JJ cord-023095-4dannjjm 6646 3 M m CD cord-023095-4dannjjm 6646 4 waves wave NNS cord-023095-4dannjjm 6646 5 with with IN cord-023095-4dannjjm 6646 6 incremental incremental JJ cord-023095-4dannjjm 6646 7 responses response NNS cord-023095-4dannjjm 6646 8 at at IN cord-023095-4dannjjm 6646 9 high high JJ cord-023095-4dannjjm 6646 10 rates rate NNS cord-023095-4dannjjm 6646 11 are be VBP cord-023095-4dannjjm 6646 12 supportive supportive JJ cord-023095-4dannjjm 6646 13 of of IN cord-023095-4dannjjm 6646 14 a a DT cord-023095-4dannjjm 6646 15 presynaptic presynaptic JJ cord-023095-4dannjjm 6646 16 neuromuscular neuromuscular JJ cord-023095-4dannjjm 6646 17 disorder disorder NN cord-023095-4dannjjm 6646 18 which which WDT cord-023095-4dannjjm 6646 19 botulism botulism NN cord-023095-4dannjjm 6646 20 was be VBD cord-023095-4dannjjm 6646 21 the the DT cord-023095-4dannjjm 6646 22 most most RBS cord-023095-4dannjjm 6646 23 likely likely JJ cord-023095-4dannjjm 6646 24 cause cause NN cord-023095-4dannjjm 6646 25 in in IN cord-023095-4dannjjm 6646 26 these these DT cord-023095-4dannjjm 6646 27 foals foal NNS cord-023095-4dannjjm 6646 28 . . . cord-023095-4dannjjm 6647 1 Repetitive repetitive JJ cord-023095-4dannjjm 6647 2 nerve nerve NN cord-023095-4dannjjm 6647 3 stimulation stimulation NN cord-023095-4dannjjm 6647 4 is be VBZ cord-023095-4dannjjm 6647 5 a a DT cord-023095-4dannjjm 6647 6 safe safe JJ cord-023095-4dannjjm 6647 7 , , , cord-023095-4dannjjm 6647 8 simple simple JJ cord-023095-4dannjjm 6647 9 , , , cord-023095-4dannjjm 6647 10 fast fast JJ cord-023095-4dannjjm 6647 11 , , , cord-023095-4dannjjm 6647 12 and and CC cord-023095-4dannjjm 6647 13 non non JJ cord-023095-4dannjjm 6647 14 - - JJ cord-023095-4dannjjm 6647 15 invasive invasive JJ cord-023095-4dannjjm 6647 16 technique technique NN cord-023095-4dannjjm 6647 17 that that WDT cord-023095-4dannjjm 6647 18 can can MD cord-023095-4dannjjm 6647 19 aid aid VB cord-023095-4dannjjm 6647 20 in in IN cord-023095-4dannjjm 6647 21 the the DT cord-023095-4dannjjm 6647 22 diagnosis diagnosis NN cord-023095-4dannjjm 6647 23 of of IN cord-023095-4dannjjm 6647 24 suspected suspect VBN cord-023095-4dannjjm 6647 25 botulism botulism NN cord-023095-4dannjjm 6647 26 in in IN cord-023095-4dannjjm 6647 27 foals foal NNS cord-023095-4dannjjm 6647 28 . . . cord-023095-4dannjjm 6648 1 This this DT cord-023095-4dannjjm 6648 2 study study NN cord-023095-4dannjjm 6648 3 examined examine VBD cord-023095-4dannjjm 6648 4 the the DT cord-023095-4dannjjm 6648 5 frequency frequency NN cord-023095-4dannjjm 6648 6 with with IN cord-023095-4dannjjm 6648 7 which which WDT cord-023095-4dannjjm 6648 8 dogs dog NNS cord-023095-4dannjjm 6648 9 are be VBP cord-023095-4dannjjm 6648 10 exposed expose VBN cord-023095-4dannjjm 6648 11 to to IN cord-023095-4dannjjm 6648 12 E. E. NNP cord-023095-4dannjjm 6648 13 chaffeensis chaffeensis NNP cord-023095-4dannjjm 6648 14 and and CC cord-023095-4dannjjm 6648 15 E. E. NNP cord-023095-4dannjjm 6648 16 ewingii ewingii NNP cord-023095-4dannjjm 6648 17 relative relative NN cord-023095-4dannjjm 6648 18 to to IN cord-023095-4dannjjm 6648 19 E. E. NNP cord-023095-4dannjjm 6648 20 canis canis NNP cord-023095-4dannjjm 6648 21 , , , cord-023095-4dannjjm 6648 22 which which WDT cord-023095-4dannjjm 6648 23 is be VBZ cord-023095-4dannjjm 6648 24 transmitted transmit VBN cord-023095-4dannjjm 6648 25 by by IN cord-023095-4dannjjm 6648 26 the the DT cord-023095-4dannjjm 6648 27 more more RBR cord-023095-4dannjjm 6648 28 ubiquitously ubiquitously RB cord-023095-4dannjjm 6648 29 distributed distribute VBN cord-023095-4dannjjm 6648 30 brown brown JJ cord-023095-4dannjjm 6648 31 dog dog NN cord-023095-4dannjjm 6648 32 tick tick NN cord-023095-4dannjjm 6648 33 ( ( -LRB- cord-023095-4dannjjm 6648 34 Rhipicephalus Rhipicephalus NNP cord-023095-4dannjjm 6648 35 sanguineus sanguineus NNP cord-023095-4dannjjm 6648 36 ) ) -RRB- cord-023095-4dannjjm 6648 37 . . . cord-023095-4dannjjm 6649 1 A a DT cord-023095-4dannjjm 6649 2 total total NN cord-023095-4dannjjm 6649 3 of of IN cord-023095-4dannjjm 6649 4 6,512 6,512 CD cord-023095-4dannjjm 6649 5 canine canine JJ cord-023095-4dannjjm 6649 6 serum serum NN cord-023095-4dannjjm 6649 7 samples sample NNS cord-023095-4dannjjm 6649 8 , , , cord-023095-4dannjjm 6649 9 ranging range VBG cord-023095-4dannjjm 6649 10 from from IN cord-023095-4dannjjm 6649 11 182 182 CD cord-023095-4dannjjm 6649 12 to to IN cord-023095-4dannjjm 6649 13 614 614 CD cord-023095-4dannjjm 6649 14 from from IN cord-023095-4dannjjm 6649 15 each each DT cord-023095-4dannjjm 6649 16 of of IN cord-023095-4dannjjm 6649 17 the the DT cord-023095-4dannjjm 6649 18 14 14 CD cord-023095-4dannjjm 6649 19 participating participate VBG cord-023095-4dannjjm 6649 20 institutions institution NNS cord-023095-4dannjjm 6649 21 , , , cord-023095-4dannjjm 6649 22 collected collect VBN cord-023095-4dannjjm 6649 23 at at IN cord-023095-4dannjjm 6649 24 random random JJ cord-023095-4dannjjm 6649 25 from from IN cord-023095-4dannjjm 6649 26 clinical clinical JJ cord-023095-4dannjjm 6649 27 accessions accession NNS cord-023095-4dannjjm 6649 28 , , , cord-023095-4dannjjm 6649 29 diagnostic diagnostic JJ cord-023095-4dannjjm 6649 30 laboratories laboratory NNS cord-023095-4dannjjm 6649 31 and/or and/or CC cord-023095-4dannjjm 6649 32 shelters shelter NNS cord-023095-4dannjjm 6649 33 were be VBD cord-023095-4dannjjm 6649 34 evaluated evaluate VBN cord-023095-4dannjjm 6649 35 . . . cord-023095-4dannjjm 6650 1 All all DT cord-023095-4dannjjm 6650 2 serum serum NN cord-023095-4dannjjm 6650 3 samples sample NNS cord-023095-4dannjjm 6650 4 were be VBD cord-023095-4dannjjm 6650 5 tested test VBN cord-023095-4dannjjm 6650 6 by by IN cord-023095-4dannjjm 6650 7 three three CD cord-023095-4dannjjm 6650 8 microtiter microtiter NN cord-023095-4dannjjm 6650 9 plate plate NN cord-023095-4dannjjm 6650 10 ELISAs elisa NNS cord-023095-4dannjjm 6650 11 using use VBG cord-023095-4dannjjm 6650 12 species species NN cord-023095-4dannjjm 6650 13 - - HYPH cord-023095-4dannjjm 6650 14 specific specific JJ cord-023095-4dannjjm 6650 15 peptides peptide NNS cord-023095-4dannjjm 6650 16 for for IN cord-023095-4dannjjm 6650 17 antibodies antibody NNS cord-023095-4dannjjm 6650 18 to to IN cord-023095-4dannjjm 6650 19 E. E. NNP cord-023095-4dannjjm 6650 20 canis canis NNP cord-023095-4dannjjm 6650 21 , , , cord-023095-4dannjjm 6650 22 E. E. NNP cord-023095-4dannjjm 6650 23 chaffeensis chaffeensis NNP cord-023095-4dannjjm 6650 24 and and CC cord-023095-4dannjjm 6650 25 E. E. NNP cord-023095-4dannjjm 6650 26 ewingii ewingii NNP cord-023095-4dannjjm 6650 27 . . . cord-023095-4dannjjm 6651 1 Zip zip NN cord-023095-4dannjjm 6651 2 code code NN cord-023095-4dannjjm 6651 3 information information NN cord-023095-4dannjjm 6651 4 for for IN cord-023095-4dannjjm 6651 5 sample sample NN cord-023095-4dannjjm 6651 6 origin origin NN cord-023095-4dannjjm 6651 7 was be VBD cord-023095-4dannjjm 6651 8 provided provide VBN cord-023095-4dannjjm 6651 9 by by IN cord-023095-4dannjjm 6651 10 the the DT cord-023095-4dannjjm 6651 11 collaborator collaborator NN cord-023095-4dannjjm 6651 12 and and CC cord-023095-4dannjjm 6651 13 was be VBD cord-023095-4dannjjm 6651 14 used use VBN cord-023095-4dannjjm 6651 15 to to TO cord-023095-4dannjjm 6651 16 assess assess VB cord-023095-4dannjjm 6651 17 seroprevalence seroprevalence NN cord-023095-4dannjjm 6651 18 by by IN cord-023095-4dannjjm 6651 19 region region NN cord-023095-4dannjjm 6651 20 . . . cord-023095-4dannjjm 6652 1 Comparisons comparison NNS cord-023095-4dannjjm 6652 2 were be VBD cord-023095-4dannjjm 6652 3 evaluated evaluate VBN cord-023095-4dannjjm 6652 4 using use VBG cord-023095-4dannjjm 6652 5 the the DT cord-023095-4dannjjm 6652 6 Chi Chi NNP cord-023095-4dannjjm 6652 7 - - HYPH cord-023095-4dannjjm 6652 8 square square JJ cord-023095-4dannjjm 6652 9 test test NN cord-023095-4dannjjm 6652 10 . . . cord-023095-4dannjjm 6653 1 Seroreactivity Seroreactivity NNP cord-023095-4dannjjm 6653 2 for for IN cord-023095-4dannjjm 6653 3 at at RB cord-023095-4dannjjm 6653 4 least least JJS cord-023095-4dannjjm 6653 5 2 2 CD cord-023095-4dannjjm 6653 6 of of IN cord-023095-4dannjjm 6653 7 3 3 CD cord-023095-4dannjjm 6653 8 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 6653 9 spp spp NNS cord-023095-4dannjjm 6653 10 was be VBD cord-023095-4dannjjm 6653 11 found find VBN cord-023095-4dannjjm 6653 12 in in IN cord-023095-4dannjjm 6653 13 samples sample NNS cord-023095-4dannjjm 6653 14 from from IN cord-023095-4dannjjm 6653 15 every every DT cord-023095-4dannjjm 6653 16 institution institution NN cord-023095-4dannjjm 6654 1 Both both DT cord-023095-4dannjjm 6654 2 Mississippi Mississippi NNP cord-023095-4dannjjm 6654 3 and and CC cord-023095-4dannjjm 6654 4 Oklahoma Oklahoma NNP cord-023095-4dannjjm 6654 5 had have VBD cord-023095-4dannjjm 6654 6 greater great JJR cord-023095-4dannjjm 6654 7 than than IN cord-023095-4dannjjm 6654 8 a a DT cord-023095-4dannjjm 6654 9 7 7 CD cord-023095-4dannjjm 6654 10 % % NN cord-023095-4dannjjm 6654 11 Samples sample NNS cord-023095-4dannjjm 6654 12 from from IN cord-023095-4dannjjm 6654 13 Ohio Ohio NNP cord-023095-4dannjjm 6654 14 had have VBD cord-023095-4dannjjm 6654 15 the the DT cord-023095-4dannjjm 6654 16 lowest low JJS cord-023095-4dannjjm 6654 17 aggregate aggregate JJ cord-023095-4dannjjm 6654 18 seroprevalence seroprevalence NN cord-023095-4dannjjm 6654 19 ( ( -LRB- cord-023095-4dannjjm 6654 20 1.0 1.0 CD cord-023095-4dannjjm 6654 21 % % NN cord-023095-4dannjjm 6654 22 ) ) -RRB- cord-023095-4dannjjm 6654 23 with with IN cord-023095-4dannjjm 6654 24 only only RB cord-023095-4dannjjm 6654 25 4 4 CD cord-023095-4dannjjm 6654 26 dogs dog NNS cord-023095-4dannjjm 6654 27 E. E. NNP cord-023095-4dannjjm 6654 28 canis canis NN cord-023095-4dannjjm 6654 29 seropositive seropositive NN cord-023095-4dannjjm 6654 30 , , , cord-023095-4dannjjm 6654 31 one one CD cord-023095-4dannjjm 6654 32 E. E. NNP cord-023095-4dannjjm 6654 33 ewingii ewingii NN cord-023095-4dannjjm 6654 34 seropositive seropositive JJ cord-023095-4dannjjm 6654 35 and and CC cord-023095-4dannjjm 6654 36 no no DT cord-023095-4dannjjm 6654 37 E. E. NNP cord-023095-4dannjjm 6654 38 chaffeensis chaffeensis FW cord-023095-4dannjjm 6654 39 seroreactors seroreactors NNP cord-023095-4dannjjm 6654 40 . . . cord-023095-4dannjjm 6655 1 The the DT cord-023095-4dannjjm 6655 2 geospatial geospatial JJ cord-023095-4dannjjm 6655 3 pattern pattern NN cord-023095-4dannjjm 6655 4 of of IN cord-023095-4dannjjm 6655 5 E. E. NNP cord-023095-4dannjjm 6655 6 chaffeensis chaffeensis NNP cord-023095-4dannjjm 6655 7 and and CC cord-023095-4dannjjm 6655 8 E. E. NNP cord-023095-4dannjjm 6655 9 ewingii ewingii NNP cord-023095-4dannjjm 6656 1 seropositive seropositive JJ cord-023095-4dannjjm 6656 2 samples sample NNS cord-023095-4dannjjm 6656 3 was be VBD cord-023095-4dannjjm 6656 4 similar similar JJ cord-023095-4dannjjm 6656 5 to to IN cord-023095-4dannjjm 6656 6 that that DT cord-023095-4dannjjm 6656 7 previously previously RB cord-023095-4dannjjm 6656 8 reported report VBN cord-023095-4dannjjm 6656 9 based base VBN cord-023095-4dannjjm 6656 10 on on IN cord-023095-4dannjjm 6656 11 modeling model VBG cord-023095-4dannjjm 6656 12 seroreactivity seroreactivity NN cord-023095-4dannjjm 6656 13 to to IN cord-023095-4dannjjm 6656 14 E. E. NNP cord-023095-4dannjjm 6656 15 chaffeensis chaffeensis NN cord-023095-4dannjjm 6656 16 in in IN cord-023095-4dannjjm 6656 17 white white JJ cord-023095-4dannjjm 6656 18 - - HYPH cord-023095-4dannjjm 6656 19 tailed tailed JJ cord-023095-4dannjjm 6656 20 deer deer NN cord-023095-4dannjjm 6656 21 as as RB cord-023095-4dannjjm 6656 22 well well RB cord-023095-4dannjjm 6656 23 as as IN cord-023095-4dannjjm 6656 24 the the DT cord-023095-4dannjjm 6656 25 distribution distribution NN cord-023095-4dannjjm 6656 26 of of IN cord-023095-4dannjjm 6656 27 human human JJ cord-023095-4dannjjm 6656 28 monocytic monocytic JJ cord-023095-4dannjjm 6656 29 ehrlichiosis ehrlichiosis NNP cord-023095-4dannjjm 6656 30 ( ( -LRB- cord-023095-4dannjjm 6656 31 HME HME NNP cord-023095-4dannjjm 6656 32 ) ) -RRB- cord-023095-4dannjjm 6656 33 cases case NNS cord-023095-4dannjjm 6656 34 reported report VBN cord-023095-4dannjjm 6656 35 by by IN cord-023095-4dannjjm 6656 36 the the DT cord-023095-4dannjjm 6656 37 CDC CDC NNP cord-023095-4dannjjm 6656 38 . . . cord-023095-4dannjjm 6657 1 This this DT cord-023095-4dannjjm 6657 2 study study NN cord-023095-4dannjjm 6657 3 provides provide VBZ cord-023095-4dannjjm 6657 4 the the DT cord-023095-4dannjjm 6657 5 first first JJ cord-023095-4dannjjm 6657 6 large large JJ cord-023095-4dannjjm 6657 7 scale scale NN cord-023095-4dannjjm 6657 8 regional regional JJ cord-023095-4dannjjm 6657 9 documentation documentation NN cord-023095-4dannjjm 6657 10 of of IN cord-023095-4dannjjm 6657 11 canine canine JJ cord-023095-4dannjjm 6657 12 exposure exposure NN cord-023095-4dannjjm 6657 13 to to IN cord-023095-4dannjjm 6657 14 these these DT cord-023095-4dannjjm 6657 15 three three CD cord-023095-4dannjjm 6657 16 Ehrlichia Ehrlichia NNP cord-023095-4dannjjm 6657 17 spp spp NNS cord-023095-4dannjjm 6657 18 . . . cord-023095-4dannjjm 6658 1 , , , cord-023095-4dannjjm 6658 2 highlighting highlight VBG cord-023095-4dannjjm 6658 3 where where WRB cord-023095-4dannjjm 6658 4 infections infection NNS cord-023095-4dannjjm 6658 5 most most RBS cord-023095-4dannjjm 6658 6 commonly commonly RB cord-023095-4dannjjm 6658 7 occur occur VBP cord-023095-4dannjjm 6658 8 and and CC cord-023095-4dannjjm 6658 9 thus thus RB cord-023095-4dannjjm 6658 10 identifying identify VBG cord-023095-4dannjjm 6658 11 areas area NNS cord-023095-4dannjjm 6658 12 where where WRB cord-023095-4dannjjm 6658 13 heightened heightened JJ cord-023095-4dannjjm 6658 14 awareness awareness NN cord-023095-4dannjjm 6658 15 about about IN cord-023095-4dannjjm 6658 16 these these DT cord-023095-4dannjjm 6658 17 emerging emerge VBG cord-023095-4dannjjm 6658 18 vector vector NN cord-023095-4dannjjm 6658 19 Urinary urinary JJ cord-023095-4dannjjm 6658 20 incontinence incontinence NN cord-023095-4dannjjm 6658 21 ( ( -LRB- cord-023095-4dannjjm 6658 22 UI UI NNP cord-023095-4dannjjm 6658 23 ) ) -RRB- cord-023095-4dannjjm 6658 24 occurs occur VBZ cord-023095-4dannjjm 6658 25 in in IN cord-023095-4dannjjm 6658 26 approximately approximately RB cord-023095-4dannjjm 6658 27 20 20 CD cord-023095-4dannjjm 6658 28 % % NN cord-023095-4dannjjm 6658 29 of of IN cord-023095-4dannjjm 6658 30 spayed spayed JJ cord-023095-4dannjjm 6658 31 female female JJ cord-023095-4dannjjm 6658 32 dogs dog NNS cord-023095-4dannjjm 6658 33 . . . cord-023095-4dannjjm 6659 1 The the DT cord-023095-4dannjjm 6659 2 most most RBS cord-023095-4dannjjm 6659 3 common common JJ cord-023095-4dannjjm 6659 4 cause cause NN cord-023095-4dannjjm 6659 5 is be VBZ cord-023095-4dannjjm 6659 6 urethral urethral JJ cord-023095-4dannjjm 6659 7 sphincter sphincter NN cord-023095-4dannjjm 6659 8 mechanism mechanism NN cord-023095-4dannjjm 6659 9 incompetency incompetency NN cord-023095-4dannjjm 6659 10 ( ( -LRB- cord-023095-4dannjjm 6659 11 USMI USMI NNP cord-023095-4dannjjm 6659 12 ) ) -RRB- cord-023095-4dannjjm 6659 13 . . . cord-023095-4dannjjm 6660 1 Pharmacological pharmacological JJ cord-023095-4dannjjm 6660 2 agents agent NNS cord-023095-4dannjjm 6660 3 are be VBP cord-023095-4dannjjm 6660 4 effective effective JJ cord-023095-4dannjjm 6660 5 , , , cord-023095-4dannjjm 6660 6 however however RB cord-023095-4dannjjm 6660 7 , , , cord-023095-4dannjjm 6660 8 not not RB cord-023095-4dannjjm 6660 9 all all DT cord-023095-4dannjjm 6660 10 dogs dog NNS cord-023095-4dannjjm 6660 11 respond respond VBP cord-023095-4dannjjm 6660 12 , , , cord-023095-4dannjjm 6660 13 and and CC cord-023095-4dannjjm 6660 14 dogs dog NNS cord-023095-4dannjjm 6660 15 may may MD cord-023095-4dannjjm 6660 16 become become VB cord-023095-4dannjjm 6660 17 refractory refractory JJ cord-023095-4dannjjm 6660 18 to to IN cord-023095-4dannjjm 6660 19 treatment treatment NN cord-023095-4dannjjm 6660 20 over over IN cord-023095-4dannjjm 6660 21 time time NN cord-023095-4dannjjm 6660 22 . . . cord-023095-4dannjjm 6661 1 Urethral urethral JJ cord-023095-4dannjjm 6661 2 bulking bulking NN cord-023095-4dannjjm 6661 3 , , , cord-023095-4dannjjm 6661 4 where where WRB cord-023095-4dannjjm 6661 5 a a DT cord-023095-4dannjjm 6661 6 compound compound NN cord-023095-4dannjjm 6661 7 is be VBZ cord-023095-4dannjjm 6661 8 injected inject VBN cord-023095-4dannjjm 6661 9 submucosally submucosally RB cord-023095-4dannjjm 6661 10 in in IN cord-023095-4dannjjm 6661 11 the the DT cord-023095-4dannjjm 6661 12 urethra urethra NN cord-023095-4dannjjm 6661 13 , , , cord-023095-4dannjjm 6661 14 has have VBZ cord-023095-4dannjjm 6661 15 been be VBN cord-023095-4dannjjm 6661 16 used use VBN cord-023095-4dannjjm 6661 17 in in IN cord-023095-4dannjjm 6661 18 women woman NNS cord-023095-4dannjjm 6661 19 and and CC cord-023095-4dannjjm 6661 20 in in IN cord-023095-4dannjjm 6661 21 female female JJ cord-023095-4dannjjm 6661 22 dogs dog NNS cord-023095-4dannjjm 6661 23 with with IN cord-023095-4dannjjm 6661 24 urinary urinary JJ cord-023095-4dannjjm 6661 25 incontinence incontinence NN cord-023095-4dannjjm 6661 26 . . . cord-023095-4dannjjm 6662 1 New new JJ cord-023095-4dannjjm 6662 2 synthetic synthetic JJ cord-023095-4dannjjm 6662 3 compounds compound NNS cord-023095-4dannjjm 6662 4 have have VBP cord-023095-4dannjjm 6662 5 been be VBN cord-023095-4dannjjm 6662 6 used use VBN cord-023095-4dannjjm 6662 7 in in IN cord-023095-4dannjjm 6662 8 human human JJ cord-023095-4dannjjm 6662 9 medicine medicine NN cord-023095-4dannjjm 6662 10 ; ; : cord-023095-4dannjjm 6662 11 the the DT cord-023095-4dannjjm 6662 12 most most RBS cord-023095-4dannjjm 6662 13 promising promising JJ cord-023095-4dannjjm 6662 14 is be VBZ cord-023095-4dannjjm 6662 15 Polydimethylsiloxane Polydimethylsiloxane NNP cord-023095-4dannjjm 6662 16 ( ( -LRB- cord-023095-4dannjjm 6662 17 PDMS PDMS NNP cord-023095-4dannjjm 6662 18 ) ) -RRB- cord-023095-4dannjjm 6662 19 , , , cord-023095-4dannjjm 6662 20 which which WDT cord-023095-4dannjjm 6662 21 has have VBZ cord-023095-4dannjjm 6662 22 been be VBN cord-023095-4dannjjm 6662 23 shown show VBN cord-023095-4dannjjm 6662 24 to to TO cord-023095-4dannjjm 6662 25 be be VB cord-023095-4dannjjm 6662 26 more more RBR cord-023095-4dannjjm 6662 27 effective effective JJ cord-023095-4dannjjm 6662 28 than than IN cord-023095-4dannjjm 6662 29 glutaraldehyde glutaraldehyde JJ cord-023095-4dannjjm 6662 30 cross cross JJ cord-023095-4dannjjm 6662 31 - - JJ cord-023095-4dannjjm 6662 32 linked link VBN cord-023095-4dannjjm 6662 33 collagen collagen NN cord-023095-4dannjjm 6662 34 . . . cord-023095-4dannjjm 6663 1 The the DT cord-023095-4dannjjm 6663 2 purpose purpose NN cord-023095-4dannjjm 6663 3 of of IN cord-023095-4dannjjm 6663 4 this this DT cord-023095-4dannjjm 6663 5 descriptive descriptive JJ cord-023095-4dannjjm 6663 6 clinical clinical JJ cord-023095-4dannjjm 6663 7 trial trial NN cord-023095-4dannjjm 6663 8 is be VBZ cord-023095-4dannjjm 6663 9 to to TO cord-023095-4dannjjm 6663 10 evaluate evaluate VB cord-023095-4dannjjm 6663 11 the the DT cord-023095-4dannjjm 6663 12 safety safety NN cord-023095-4dannjjm 6663 13 and and CC cord-023095-4dannjjm 6663 14 effectiveness effectiveness NN cord-023095-4dannjjm 6663 15 of of IN cord-023095-4dannjjm 6663 16 PDMS PDMS NNP cord-023095-4dannjjm 6663 17 urethral urethral JJ cord-023095-4dannjjm 6663 18 bulking bulk VBG cord-023095-4dannjjm 6663 19 agent agent NN cord-023095-4dannjjm 6663 20 ( ( -LRB- cord-023095-4dannjjm 6663 21 PDMS PDMS NNP cord-023095-4dannjjm 6663 22 UBA UBA NNP cord-023095-4dannjjm 6663 23 ) ) -RRB- cord-023095-4dannjjm 6663 24 in in IN cord-023095-4dannjjm 6663 25 client client NN cord-023095-4dannjjm 6663 26 - - HYPH cord-023095-4dannjjm 6663 27 owned own VBN cord-023095-4dannjjm 6663 28 , , , cord-023095-4dannjjm 6663 29 spayed spay VBN cord-023095-4dannjjm 6663 30 female female JJ cord-023095-4dannjjm 6663 31 dogs dog NNS cord-023095-4dannjjm 6663 32 with with IN cord-023095-4dannjjm 6663 33 naturally naturally RB cord-023095-4dannjjm 6663 34 - - HYPH cord-023095-4dannjjm 6663 35 occurring occur VBG cord-023095-4dannjjm 6663 36 UI UI NNP cord-023095-4dannjjm 6663 37 due due IN cord-023095-4dannjjm 6663 38 to to IN cord-023095-4dannjjm 6663 39 USMI.Twenty usmi.twenty CD cord-023095-4dannjjm 6663 40 - - HYPH cord-023095-4dannjjm 6663 41 two two CD cord-023095-4dannjjm 6663 42 , , , cord-023095-4dannjjm 6663 43 spayed spay VBN cord-023095-4dannjjm 6663 44 female female JJ cord-023095-4dannjjm 6663 45 dogs dog NNS cord-023095-4dannjjm 6663 46 were be VBD cord-023095-4dannjjm 6663 47 included include VBN cord-023095-4dannjjm 6663 48 . . . cord-023095-4dannjjm 6664 1 Dogs dog NNS cord-023095-4dannjjm 6664 2 had have VBD cord-023095-4dannjjm 6664 3 a a DT cord-023095-4dannjjm 6664 4 median median JJ cord-023095-4dannjjm 6664 5 age age NN cord-023095-4dannjjm 6664 6 of of IN cord-023095-4dannjjm 6664 7 6 6 CD cord-023095-4dannjjm 6664 8 years year NNS cord-023095-4dannjjm 6664 9 ( ( -LRB- cord-023095-4dannjjm 6664 10 2 2 CD cord-023095-4dannjjm 6664 11 to to TO cord-023095-4dannjjm 6664 12 11 11 CD cord-023095-4dannjjm 6664 13 years year NNS cord-023095-4dannjjm 6664 14 ) ) -RRB- cord-023095-4dannjjm 6664 15 . . . cord-023095-4dannjjm 6665 1 Eighteen eighteen CD cord-023095-4dannjjm 6665 2 dog dog NN cord-023095-4dannjjm 6665 3 breeds breed NNS cord-023095-4dannjjm 6665 4 were be VBD cord-023095-4dannjjm 6665 5 represented represent VBN cord-023095-4dannjjm 6665 6 , , , cord-023095-4dannjjm 6665 7 and and CC cord-023095-4dannjjm 6665 8 dogs dog NNS cord-023095-4dannjjm 6665 9 weighed weigh VBD cord-023095-4dannjjm 6665 10 a a DT cord-023095-4dannjjm 6665 11 median median NN cord-023095-4dannjjm 6665 12 of of IN cord-023095-4dannjjm 6665 13 29.9 29.9 CD cord-023095-4dannjjm 6665 14 kg kg NNS cord-023095-4dannjjm 6665 15 ( ( -LRB- cord-023095-4dannjjm 6665 16 7.3 7.3 CD cord-023095-4dannjjm 6665 17 to to IN cord-023095-4dannjjm 6665 18 62.7 62.7 CD cord-023095-4dannjjm 6665 19 kg kg NNS cord-023095-4dannjjm 6665 20 ) ) -RRB- cord-023095-4dannjjm 6665 21 . . . cord-023095-4dannjjm 6666 1 Average average JJ cord-023095-4dannjjm 6666 2 length length NN cord-023095-4dannjjm 6666 3 of of IN cord-023095-4dannjjm 6666 4 time time NN cord-023095-4dannjjm 6666 5 of of IN cord-023095-4dannjjm 6666 6 UI UI NNP cord-023095-4dannjjm 6666 7 was be VBD cord-023095-4dannjjm 6666 8 2.5 2.5 CD cord-023095-4dannjjm 6666 9 AE AE NNP cord-023095-4dannjjm 6666 10 2.3 2.3 CD cord-023095-4dannjjm 6666 11 years year NNS cord-023095-4dannjjm 6666 12 ; ; : cord-023095-4dannjjm 6666 13 18/22 18/22 CD cord-023095-4dannjjm 6666 14 dogs dog NNS cord-023095-4dannjjm 6666 15 had have VBD cord-023095-4dannjjm 6666 16 been be VBN cord-023095-4dannjjm 6666 17 treated treat VBN cord-023095-4dannjjm 6666 18 medically medically RB cord-023095-4dannjjm 6666 19 , , , cord-023095-4dannjjm 6666 20 of of IN cord-023095-4dannjjm 6666 21 which which WDT cord-023095-4dannjjm 6666 22 2/18 2/18 CD cord-023095-4dannjjm 6666 23 were be VBD cord-023095-4dannjjm 6666 24 continent continent VBN cord-023095-4dannjjm 6666 25 , , , cord-023095-4dannjjm 6666 26 14/18 14/18 CD cord-023095-4dannjjm 6666 27 were be VBD cord-023095-4dannjjm 6666 28 improved improve VBN cord-023095-4dannjjm 6666 29 , , , cord-023095-4dannjjm 6666 30 and and CC cord-023095-4dannjjm 6666 31 2/18 2/18 CD cord-023095-4dannjjm 6666 32 had have VBD cord-023095-4dannjjm 6666 33 no no DT cord-023095-4dannjjm 6666 34 improvement improvement NN cord-023095-4dannjjm 6666 35 . . . cord-023095-4dannjjm 6667 1 Dogs dog NNS cord-023095-4dannjjm 6667 2 were be VBD cord-023095-4dannjjm 6667 3 deemed deem VBN cord-023095-4dannjjm 6667 4 healthy healthy JJ cord-023095-4dannjjm 6667 5 based base VBN cord-023095-4dannjjm 6667 6 on on IN cord-023095-4dannjjm 6667 7 results result NNS cord-023095-4dannjjm 6667 8 of of IN cord-023095-4dannjjm 6667 9 physical physical JJ cord-023095-4dannjjm 6667 10 examination examination NN cord-023095-4dannjjm 6667 11 , , , cord-023095-4dannjjm 6667 12 complete complete JJ cord-023095-4dannjjm 6667 13 blood blood NN cord-023095-4dannjjm 6667 14 cell cell NN cord-023095-4dannjjm 6667 15 counts count NNS cord-023095-4dannjjm 6667 16 , , , cord-023095-4dannjjm 6667 17 plasma plasma NN cord-023095-4dannjjm 6667 18 biochemical biochemical JJ cord-023095-4dannjjm 6667 19 analysis analysis NN cord-023095-4dannjjm 6667 20 , , , cord-023095-4dannjjm 6667 21 and and CC cord-023095-4dannjjm 6667 22 urinalysis urinalysis NN cord-023095-4dannjjm 6667 23 ; ; : cord-023095-4dannjjm 6667 24 urine urine NN cord-023095-4dannjjm 6667 25 cultures culture NNS cord-023095-4dannjjm 6667 26 were be VBD cord-023095-4dannjjm 6667 27 negative negative JJ cord-023095-4dannjjm 6667 28 . . . cord-023095-4dannjjm 6668 1 Dogs dog NNS cord-023095-4dannjjm 6668 2 were be VBD cord-023095-4dannjjm 6668 3 anesthetized anesthetize VBN cord-023095-4dannjjm 6668 4 , , , cord-023095-4dannjjm 6668 5 positioned position VBN cord-023095-4dannjjm 6668 6 in in IN cord-023095-4dannjjm 6668 7 dorsal dorsal JJ cord-023095-4dannjjm 6668 8 recumbency recumbency NN cord-023095-4dannjjm 6668 9 , , , cord-023095-4dannjjm 6668 10 and and CC cord-023095-4dannjjm 6668 11 cystoscopy cystoscopy NN cord-023095-4dannjjm 6668 12 performed perform VBN cord-023095-4dannjjm 6668 13 using use VBG cord-023095-4dannjjm 6668 14 a a DT cord-023095-4dannjjm 6668 15 2.7 2.7 CD cord-023095-4dannjjm 6668 16 mm mm NN cord-023095-4dannjjm 6668 17 , , , cord-023095-4dannjjm 6668 18 0-or 0-or CD cord-023095-4dannjjm 6668 19 30-degree 30-degree CD cord-023095-4dannjjm 6668 20 , , , cord-023095-4dannjjm 6668 21 18 18 CD cord-023095-4dannjjm 6668 22 cm cm NN cord-023095-4dannjjm 6668 23 rigid rigid JJ cord-023095-4dannjjm 6668 24 cystoscope cystoscope NN cord-023095-4dannjjm 6668 25 . . . cord-023095-4dannjjm 6669 1 Urethral urethral JJ cord-023095-4dannjjm 6669 2 bulking bulking NN cord-023095-4dannjjm 6669 3 was be VBD cord-023095-4dannjjm 6669 4 performed perform VBN cord-023095-4dannjjm 6669 5 with with IN cord-023095-4dannjjm 6669 6 PDMS PDMS NNP cord-023095-4dannjjm 6669 7 UBA UBA NNP cord-023095-4dannjjm 6669 8 . . . cord-023095-4dannjjm 6670 1 On on IN cord-023095-4dannjjm 6670 2 average average JJ cord-023095-4dannjjm 6670 3 , , , cord-023095-4dannjjm 6670 4 2.5 2.5 CD cord-023095-4dannjjm 6670 5 AE AE NNP cord-023095-4dannjjm 6670 6 0.9 0.9 CD cord-023095-4dannjjm 6670 7 ml ml NNS cord-023095-4dannjjm 6670 8 were be VBD cord-023095-4dannjjm 6670 9 injected inject VBN cord-023095-4dannjjm 6670 10 in in IN cord-023095-4dannjjm 6670 11 3 3 CD cord-023095-4dannjjm 6670 12 to to TO cord-023095-4dannjjm 6670 13 5 5 CD cord-023095-4dannjjm 6670 14 locations location NNS cord-023095-4dannjjm 6670 15 approximately approximately RB cord-023095-4dannjjm 6670 16 1 1 CD cord-023095-4dannjjm 6670 17 to to IN cord-023095-4dannjjm 6670 18 1.5 1.5 CD cord-023095-4dannjjm 6670 19 cm cm NNS cord-023095-4dannjjm 6670 20 distal distal JJ cord-023095-4dannjjm 6670 21 to to IN cord-023095-4dannjjm 6670 22 the the DT cord-023095-4dannjjm 6670 23 trigone trigone NN cord-023095-4dannjjm 6670 24 submucosally submucosally RB cord-023095-4dannjjm 6670 25 in in IN cord-023095-4dannjjm 6670 26 the the DT cord-023095-4dannjjm 6670 27 proximal proximal JJ cord-023095-4dannjjm 6670 28 urethra urethra NN cord-023095-4dannjjm 6670 29 . . . cord-023095-4dannjjm 6671 1 Good good JJ cord-023095-4dannjjm 6671 2 coaptation coaptation NN cord-023095-4dannjjm 6671 3 was be VBD cord-023095-4dannjjm 6671 4 achieved achieve VBN cord-023095-4dannjjm 6671 5 in in IN cord-023095-4dannjjm 6671 6 all all DT cord-023095-4dannjjm 6671 7 dogs dog NNS cord-023095-4dannjjm 6671 8 . . . cord-023095-4dannjjm 6672 1 The the DT cord-023095-4dannjjm 6672 2 procedure procedure NN cord-023095-4dannjjm 6672 3 took take VBD cord-023095-4dannjjm 6672 4 on on IN cord-023095-4dannjjm 6672 5 average average JJ cord-023095-4dannjjm 6672 6 15.9 15.9 CD cord-023095-4dannjjm 6672 7 AE AE NNP cord-023095-4dannjjm 6672 8 4.3 4.3 CD cord-023095-4dannjjm 6672 9 minutes minute NNS cord-023095-4dannjjm 6672 10 . . . cord-023095-4dannjjm 6673 1 One one CD cord-023095-4dannjjm 6673 2 dog dog NN cord-023095-4dannjjm 6673 3 experienced experience VBD cord-023095-4dannjjm 6673 4 urethral urethral JJ cord-023095-4dannjjm 6673 5 obstruction obstruction NN cord-023095-4dannjjm 6673 6 after after IN cord-023095-4dannjjm 6673 7 the the DT cord-023095-4dannjjm 6673 8 procedure procedure NN cord-023095-4dannjjm 6673 9 ; ; : cord-023095-4dannjjm 6673 10 a a DT cord-023095-4dannjjm 6673 11 Foley Foley NNP cord-023095-4dannjjm 6673 12 catheter catheter NN cord-023095-4dannjjm 6673 13 was be VBD cord-023095-4dannjjm 6673 14 inserted insert VBN cord-023095-4dannjjm 6673 15 for for IN cord-023095-4dannjjm 6673 16 approximately approximately RB cord-023095-4dannjjm 6673 17 12 12 CD cord-023095-4dannjjm 6673 18 hours hour NNS cord-023095-4dannjjm 6673 19 and and CC cord-023095-4dannjjm 6673 20 removed remove VBN cord-023095-4dannjjm 6673 21 at at IN cord-023095-4dannjjm 6673 22 which which WDT cord-023095-4dannjjm 6673 23 time time NN cord-023095-4dannjjm 6673 24 she -PRON- PRP cord-023095-4dannjjm 6673 25 urinated urinate VBD cord-023095-4dannjjm 6673 26 normally normally RB cord-023095-4dannjjm 6673 27 and and CC cord-023095-4dannjjm 6673 28 was be VBD cord-023095-4dannjjm 6673 29 continent continent NN cord-023095-4dannjjm 6673 30 . . . cord-023095-4dannjjm 6674 1 Three three CD cord-023095-4dannjjm 6674 2 dogs dog NNS cord-023095-4dannjjm 6674 3 experienced experience VBD cord-023095-4dannjjm 6674 4 an an DT cord-023095-4dannjjm 6674 5 acute acute JJ cord-023095-4dannjjm 6674 6 allergic allergic JJ cord-023095-4dannjjm 6674 7 reaction reaction NN cord-023095-4dannjjm 6674 8 characterized characterize VBN cord-023095-4dannjjm 6674 9 by by IN cord-023095-4dannjjm 6674 10 blepharedema blepharedema NNP cord-023095-4dannjjm 6674 11 and and CC cord-023095-4dannjjm 6674 12 urticaria urticaria NN cord-023095-4dannjjm 6674 13 treated treat VBN cord-023095-4dannjjm 6674 14 successfully successfully RB cord-023095-4dannjjm 6674 15 with with IN cord-023095-4dannjjm 6674 16 diphenhydramine diphenhydramine NN cord-023095-4dannjjm 6674 17 . . . cord-023095-4dannjjm 6675 1 Dogs dog NNS cord-023095-4dannjjm 6675 2 were be VBD cord-023095-4dannjjm 6675 3 discharged discharge VBN cord-023095-4dannjjm 6675 4 on on IN cord-023095-4dannjjm 6675 5 day day NN cord-023095-4dannjjm 6675 6 of of IN cord-023095-4dannjjm 6675 7 procedure procedure NN cord-023095-4dannjjm 6675 8 except except IN cord-023095-4dannjjm 6675 9 for for IN cord-023095-4dannjjm 6675 10 the the DT cord-023095-4dannjjm 6675 11 one one CD cord-023095-4dannjjm 6675 12 dog dog NN cord-023095-4dannjjm 6675 13 that that WDT cord-023095-4dannjjm 6675 14 experienced experience VBD cord-023095-4dannjjm 6675 15 urethral urethral JJ cord-023095-4dannjjm 6675 16 obstruction obstruction NN cord-023095-4dannjjm 6675 17 . . . cord-023095-4dannjjm 6676 1 All all DT cord-023095-4dannjjm 6676 2 dogs dog NNS cord-023095-4dannjjm 6676 3 were be VBD cord-023095-4dannjjm 6676 4 treated treat VBN cord-023095-4dannjjm 6676 5 with with IN cord-023095-4dannjjm 6676 6 Meloxicam Meloxicam NNP cord-023095-4dannjjm 6676 7 ( ( -LRB- cord-023095-4dannjjm 6676 8 0.1 0.1 CD cord-023095-4dannjjm 6676 9 mg mg NNP cord-023095-4dannjjm 6676 10 / / SYM cord-023095-4dannjjm 6676 11 kg kg NN cord-023095-4dannjjm 6676 12 PO po NN cord-023095-4dannjjm 6677 1 q24h q24h NNS cord-023095-4dannjjm 6677 2 for for IN cord-023095-4dannjjm 6677 3 3 3 CD cord-023095-4dannjjm 6677 4 days).Owners days).owner NNS cord-023095-4dannjjm 6677 5 were be VBD cord-023095-4dannjjm 6677 6 contacted contact VBN cord-023095-4dannjjm 6677 7 on on IN cord-023095-4dannjjm 6677 8 day day NN cord-023095-4dannjjm 6677 9 after after IN cord-023095-4dannjjm 6677 10 discharge discharge NN cord-023095-4dannjjm 6677 11 and and CC cord-023095-4dannjjm 6677 12 21/22 21/22 CD cord-023095-4dannjjm 6677 13 dogs dog NNS cord-023095-4dannjjm 6677 14 were be VBD cord-023095-4dannjjm 6677 15 continent continent NN cord-023095-4dannjjm 6677 16 ; ; : cord-023095-4dannjjm 6677 17 1/22 1/22 CD cord-023095-4dannjjm 6677 18 dogs dog NNS cord-023095-4dannjjm 6677 19 was be VBD cord-023095-4dannjjm 6677 20 improved improve VBN cord-023095-4dannjjm 6677 21 . . . cord-023095-4dannjjm 6678 1 Dogs dog NNS cord-023095-4dannjjm 6678 2 were be VBD cord-023095-4dannjjm 6678 3 re re VBN cord-023095-4dannjjm 6678 4 - - VBN cord-023095-4dannjjm 6678 5 evaluated evaluate VBN cord-023095-4dannjjm 6678 6 1 1 CD cord-023095-4dannjjm 6678 7 week week NN cord-023095-4dannjjm 6678 8 after after IN cord-023095-4dannjjm 6678 9 discharge discharge NN cord-023095-4dannjjm 6678 10 and and CC cord-023095-4dannjjm 6678 11 21/22 21/22 CD cord-023095-4dannjjm 6678 12 dogs dog NNS cord-023095-4dannjjm 6678 13 were be VBD cord-023095-4dannjjm 6678 14 continent continent NN cord-023095-4dannjjm 6678 15 and and CC cord-023095-4dannjjm 6678 16 1/22 1/22 CD cord-023095-4dannjjm 6678 17 dogs dog NNS cord-023095-4dannjjm 6679 1 Polyneuropathy Polyneuropathy NNP cord-023095-4dannjjm 6679 2 in in IN cord-023095-4dannjjm 6679 3 large large JJ cord-023095-4dannjjm 6679 4 breed breed NN cord-023095-4dannjjm 6679 5 dogs dog NNS cord-023095-4dannjjm 6679 6 is be VBZ cord-023095-4dannjjm 6679 7 a a DT cord-023095-4dannjjm 6679 8 relatively relatively RB cord-023095-4dannjjm 6679 9 common common JJ cord-023095-4dannjjm 6679 10 clinical clinical JJ cord-023095-4dannjjm 6679 11 problem problem NN cord-023095-4dannjjm 6679 12 for for IN cord-023095-4dannjjm 6679 13 which which WDT cord-023095-4dannjjm 6679 14 the the DT cord-023095-4dannjjm 6679 15 genetic genetic JJ cord-023095-4dannjjm 6679 16 basis basis NN cord-023095-4dannjjm 6679 17 is be VBZ cord-023095-4dannjjm 6679 18 generally generally RB cord-023095-4dannjjm 6679 19 unknown unknown JJ cord-023095-4dannjjm 6679 20 . . . cord-023095-4dannjjm 6680 1 The the DT cord-023095-4dannjjm 6680 2 first first JJ cord-023095-4dannjjm 6680 3 cases case NNS cord-023095-4dannjjm 6680 4 of of IN cord-023095-4dannjjm 6680 5 polyneuropathy polyneuropathy NNS cord-023095-4dannjjm 6680 6 in in IN cord-023095-4dannjjm 6680 7 the the DT cord-023095-4dannjjm 6680 8 Leonberger Leonberger NNP cord-023095-4dannjjm 6680 9 breed breed NN cord-023095-4dannjjm 6680 10 ( ( -LRB- cord-023095-4dannjjm 6680 11 Leonberger Leonberger NNP cord-023095-4dannjjm 6680 12 polyneuropathy polyneuropathy NNS cord-023095-4dannjjm 6680 13 or or CC cord-023095-4dannjjm 6680 14 LPN LPN NNP cord-023095-4dannjjm 6680 15 ) ) -RRB- cord-023095-4dannjjm 6680 16 were be VBD cord-023095-4dannjjm 6680 17 identified identify VBN cord-023095-4dannjjm 6680 18 in in IN cord-023095-4dannjjm 6680 19 1999 1999 CD cord-023095-4dannjjm 6680 20 by by IN cord-023095-4dannjjm 6680 21 one one CD cord-023095-4dannjjm 6680 22 of of IN cord-023095-4dannjjm 6680 23 the the DT cord-023095-4dannjjm 6680 24 authors author NNS cord-023095-4dannjjm 6680 25 ( ( -LRB- cord-023095-4dannjjm 6680 26 GDS GDS NNP cord-023095-4dannjjm 6680 27 ) ) -RRB- cord-023095-4dannjjm 6680 28 and and CC cord-023095-4dannjjm 6680 29 a a DT cord-023095-4dannjjm 6680 30 report report NN cord-023095-4dannjjm 6680 31 published publish VBN cord-023095-4dannjjm 6680 32 in in IN cord-023095-4dannjjm 6680 33 2003 2003 CD cord-023095-4dannjjm 6680 34 ( ( -LRB- cord-023095-4dannjjm 6680 35 MuscleNerve MuscleNerve NNP cord-023095-4dannjjm 6680 36 27:471 27:471 CD cord-023095-4dannjjm 6680 37 - - SYM cord-023095-4dannjjm 6680 38 477 477 CD cord-023095-4dannjjm 6680 39 ) ) -RRB- cord-023095-4dannjjm 6680 40 . . . cord-023095-4dannjjm 6681 1 In in IN cord-023095-4dannjjm 6681 2 this this DT cord-023095-4dannjjm 6681 3 report report NN cord-023095-4dannjjm 6681 4 a a DT cord-023095-4dannjjm 6681 5 spontaneous spontaneous JJ cord-023095-4dannjjm 6681 6 , , , cord-023095-4dannjjm 6681 7 distal distal JJ cord-023095-4dannjjm 6681 8 and and CC cord-023095-4dannjjm 6681 9 symmetrical symmetrical JJ cord-023095-4dannjjm 6681 10 polyneuropathy polyneuropathy NNS cord-023095-4dannjjm 6681 11 with with IN cord-023095-4dannjjm 6681 12 onset onset NN cord-023095-4dannjjm 6681 13 between between IN cord-023095-4dannjjm 6681 14 1 1 CD cord-023095-4dannjjm 6681 15 to to TO cord-023095-4dannjjm 6681 16 9 9 CD cord-023095-4dannjjm 6681 17 years year NNS cord-023095-4dannjjm 6681 18 of of IN cord-023095-4dannjjm 6681 19 age age NN cord-023095-4dannjjm 6681 20 was be VBD cord-023095-4dannjjm 6681 21 described describe VBN cord-023095-4dannjjm 6681 22 and and CC cord-023095-4dannjjm 6681 23 characterized characterize VBN cord-023095-4dannjjm 6681 24 clinically clinically RB cord-023095-4dannjjm 6681 25 , , , cord-023095-4dannjjm 6681 26 electrophysiologically electrophysiologically RB cord-023095-4dannjjm 6681 27 , , , cord-023095-4dannjjm 6681 28 histologically histologically RB cord-023095-4dannjjm 6681 29 and and CC cord-023095-4dannjjm 6681 30 morphometrically morphometrically RB cord-023095-4dannjjm 6681 31 . . . cord-023095-4dannjjm 6682 1 There there EX cord-023095-4dannjjm 6682 2 were be VBD cord-023095-4dannjjm 6682 3 striking strike VBG cord-023095-4dannjjm 6682 4 similarities similarity NNS cord-023095-4dannjjm 6682 5 between between IN cord-023095-4dannjjm 6682 6 LPN LPN NNP cord-023095-4dannjjm 6682 7 and and CC cord-023095-4dannjjm 6682 8 the the DT cord-023095-4dannjjm 6682 9 Charcot Charcot NNP cord-023095-4dannjjm 6682 10 - - HYPH cord-023095-4dannjjm 6682 11 Marie Marie NNP cord-023095-4dannjjm 6682 12 - - HYPH cord-023095-4dannjjm 6682 13 Tooth Tooth NNP cord-023095-4dannjjm 6682 14 group group NN cord-023095-4dannjjm 6682 15 of of IN cord-023095-4dannjjm 6682 16 human human JJ cord-023095-4dannjjm 6682 17 inherited inherit VBN cord-023095-4dannjjm 6682 18 sensory sensory JJ cord-023095-4dannjjm 6682 19 and and CC cord-023095-4dannjjm 6682 20 motor motor NN cord-023095-4dannjjm 6682 21 polyneuropathies polyneuropathie NNS cord-023095-4dannjjm 6682 22 , , , cord-023095-4dannjjm 6682 23 which which WDT cord-023095-4dannjjm 6682 24 have have VBP cord-023095-4dannjjm 6682 25 many many JJ cord-023095-4dannjjm 6682 26 known know VBN cord-023095-4dannjjm 6682 27 genetic genetic JJ cord-023095-4dannjjm 6682 28 mutations mutation NNS cord-023095-4dannjjm 6682 29 . . . cord-023095-4dannjjm 6683 1 A a DT cord-023095-4dannjjm 6683 2 genome genome NN cord-023095-4dannjjm 6683 3 - - HYPH cord-023095-4dannjjm 6683 4 wide wide JJ cord-023095-4dannjjm 6683 5 case case NN cord-023095-4dannjjm 6683 6 - - HYPH cord-023095-4dannjjm 6683 7 control control NN cord-023095-4dannjjm 6683 8 association association NNP cord-023095-4dannjjm 6683 9 study study NN cord-023095-4dannjjm 6683 10 for for IN cord-023095-4dannjjm 6683 11 LPN LPN NNP cord-023095-4dannjjm 6683 12 was be VBD cord-023095-4dannjjm 6683 13 performed perform VBN cord-023095-4dannjjm 6683 14 with with IN cord-023095-4dannjjm 6683 15 53 53 CD cord-023095-4dannjjm 6683 16 cases case NNS cord-023095-4dannjjm 6683 17 and and CC cord-023095-4dannjjm 6683 18 42 42 CD cord-023095-4dannjjm 6683 19 controls control NNS cord-023095-4dannjjm 6683 20 on on IN cord-023095-4dannjjm 6683 21 high high JJ cord-023095-4dannjjm 6683 22 - - HYPH cord-023095-4dannjjm 6683 23 density density NN cord-023095-4dannjjm 6683 24 170 170 CD cord-023095-4dannjjm 6683 25 K K NNP cord-023095-4dannjjm 6683 26 canine canine JJ cord-023095-4dannjjm 6683 27 SNP SNP NNP cord-023095-4dannjjm 6683 28 arrays array NNS cord-023095-4dannjjm 6683 29 and and CC cord-023095-4dannjjm 6683 30 revealed reveal VBD cord-023095-4dannjjm 6683 31 a a DT cord-023095-4dannjjm 6683 32 significantly significantly RB cord-023095-4dannjjm 6683 33 associated associate VBN cord-023095-4dannjjm 6683 34 region region NN cord-023095-4dannjjm 6683 35 on on IN cord-023095-4dannjjm 6683 36 CFA CFA NNP cord-023095-4dannjjm 6683 37 16 16 CD cord-023095-4dannjjm 6683 38 ( ( -LRB- cord-023095-4dannjjm 6683 39 P p NN cord-023095-4dannjjm 6683 40 raw raw JJ cord-023095-4dannjjm 6683 41 5 5 CD cord-023095-4dannjjm 6683 42 2.36 2.36 CD cord-023095-4dannjjm 6683 43 Â â CD cord-023095-4dannjjm 6683 44 10 10 CD cord-023095-4dannjjm 6683 45 À10 À10 NNP cord-023095-4dannjjm 6683 46 P p NN cord-023095-4dannjjm 6683 47 genome genome NN cord-023095-4dannjjm 6683 48 5 5 CD cord-023095-4dannjjm 6683 49 9.99 9.99 CD cord-023095-4dannjjm 6683 50 Â â CD cord-023095-4dannjjm 6683 51 10 10 CD cord-023095-4dannjjm 6683 52 À5 À5 NNP cord-023095-4dannjjm 6683 53 ) ) -RRB- cord-023095-4dannjjm 6683 54 . . . cord-023095-4dannjjm 6684 1 A a DT cord-023095-4dannjjm 6684 2 clear clear JJ cord-023095-4dannjjm 6684 3 association association NN cord-023095-4dannjjm 6684 4 of of IN cord-023095-4dannjjm 6684 5 an an DT cord-023095-4dannjjm 6684 6 approximately approximately RB cord-023095-4dannjjm 6684 7 1 1 CD cord-023095-4dannjjm 6684 8 Mb Mb NNP cord-023095-4dannjjm 6684 9 CFA16 CFA16 NNP cord-023095-4dannjjm 6684 10 haplotype haplotype NN cord-023095-4dannjjm 6684 11 with with IN cord-023095-4dannjjm 6684 12 cases case NNS cord-023095-4dannjjm 6684 13 ( ( -LRB- cord-023095-4dannjjm 6684 14 P p NN cord-023095-4dannjjm 6684 15 5 5 CD cord-023095-4dannjjm 6684 16 1.71 1.71 CD cord-023095-4dannjjm 6684 17 Â â CD cord-023095-4dannjjm 6684 18 10 10 CD cord-023095-4dannjjm 6684 19 À8 à8 CD cord-023095-4dannjjm 6684 20 ) ) -RRB- cord-023095-4dannjjm 6684 21 was be VBD cord-023095-4dannjjm 6684 22 observed observe VBN cord-023095-4dannjjm 6684 23 , , , cord-023095-4dannjjm 6684 24 particularly particularly RB cord-023095-4dannjjm 6684 25 with with IN cord-023095-4dannjjm 6684 26 those those DT cord-023095-4dannjjm 6684 27 cases case NNS cord-023095-4dannjjm 6684 28 that that WDT cord-023095-4dannjjm 6684 29 were be VBD cord-023095-4dannjjm 6684 30 affected affect VBN cord-023095-4dannjjm 6684 31 more more RBR cord-023095-4dannjjm 6684 32 severely severely RB cord-023095-4dannjjm 6684 33 and and CC cord-023095-4dannjjm 6684 34 at at IN cord-023095-4dannjjm 6684 35 a a DT cord-023095-4dannjjm 6684 36 younger young JJR cord-023095-4dannjjm 6684 37 age age NN cord-023095-4dannjjm 6684 38 ( ( -LRB- cord-023095-4dannjjm 6684 39 P p NN cord-023095-4dannjjm 6684 40 5 5 CD cord-023095-4dannjjm 6684 41 2.55 2.55 CD cord-023095-4dannjjm 6684 42 Â â CD cord-023095-4dannjjm 6684 43 10 10 CD cord-023095-4dannjjm 6684 44 À11 À11 NNPS cord-023095-4dannjjm 6684 45 ) ) -RRB- cord-023095-4dannjjm 6684 46 . . . cord-023095-4dannjjm 6685 1 A a DT cord-023095-4dannjjm 6685 2 positional positional JJ cord-023095-4dannjjm 6685 3 candidate candidate NN cord-023095-4dannjjm 6685 4 gene gene NN cord-023095-4dannjjm 6685 5 , , , cord-023095-4dannjjm 6685 6 ARHGEF10 ARHGEF10 NNP cord-023095-4dannjjm 6685 7 , , , cord-023095-4dannjjm 6685 8 which which WDT cord-023095-4dannjjm 6685 9 has have VBZ cord-023095-4dannjjm 6685 10 previously previously RB cord-023095-4dannjjm 6685 11 been be VBN cord-023095-4dannjjm 6685 12 associated associate VBN cord-023095-4dannjjm 6685 13 with with IN cord-023095-4dannjjm 6685 14 peripheral peripheral JJ cord-023095-4dannjjm 6685 15 nerve nerve NN cord-023095-4dannjjm 6685 16 abnormalities abnormality NNS cord-023095-4dannjjm 6685 17 in in IN cord-023095-4dannjjm 6685 18 humans human NNS cord-023095-4dannjjm 6685 19 , , , cord-023095-4dannjjm 6685 20 was be VBD cord-023095-4dannjjm 6685 21 sequenced sequence VBN cord-023095-4dannjjm 6685 22 , , , cord-023095-4dannjjm 6685 23 revealing reveal VBG cord-023095-4dannjjm 6685 24 a a DT cord-023095-4dannjjm 6685 25 deletion deletion NN cord-023095-4dannjjm 6685 26 that that WDT cord-023095-4dannjjm 6685 27 results result VBZ cord-023095-4dannjjm 6685 28 in in IN cord-023095-4dannjjm 6685 29 a a DT cord-023095-4dannjjm 6685 30 frame frame NN cord-023095-4dannjjm 6685 31 shift shift NN cord-023095-4dannjjm 6685 32 and and CC cord-023095-4dannjjm 6685 33 premature premature JJ cord-023095-4dannjjm 6685 34 stop stop NN cord-023095-4dannjjm 6685 35 codon codon NN cord-023095-4dannjjm 6685 36 . . . cord-023095-4dannjjm 6686 1 Of of IN cord-023095-4dannjjm 6686 2 all all DT cord-023095-4dannjjm 6686 3 Leonbergers Leonbergers NNPS cord-023095-4dannjjm 6686 4 with with IN cord-023095-4dannjjm 6686 5 young young JJ cord-023095-4dannjjm 6686 6 onset onset NN cord-023095-4dannjjm 6686 7 LPN LPN NNP cord-023095-4dannjjm 6686 8 ( ( -LRB- cord-023095-4dannjjm 6686 9 before before IN cord-023095-4dannjjm 6686 10 4 4 CD cord-023095-4dannjjm 6686 11 years year NNS cord-023095-4dannjjm 6686 12 ) ) -RRB- cord-023095-4dannjjm 6686 13 , , , cord-023095-4dannjjm 6686 14 48.5 48.5 CD cord-023095-4dannjjm 6686 15 % % NN cord-023095-4dannjjm 6686 16 ( ( -LRB- cord-023095-4dannjjm 6686 17 32 32 CD cord-023095-4dannjjm 6686 18 of of IN cord-023095-4dannjjm 6686 19 66 66 CD cord-023095-4dannjjm 6686 20 ) ) -RRB- cord-023095-4dannjjm 6686 21 have have VBP cord-023095-4dannjjm 6686 22 two two CD cord-023095-4dannjjm 6686 23 copies copy NNS cord-023095-4dannjjm 6686 24 of of IN cord-023095-4dannjjm 6686 25 this this DT cord-023095-4dannjjm 6686 26 deletion deletion NN cord-023095-4dannjjm 6686 27 , , , cord-023095-4dannjjm 6686 28 and and CC cord-023095-4dannjjm 6686 29 , , , cord-023095-4dannjjm 6686 30 of of IN cord-023095-4dannjjm 6686 31 all all DT cord-023095-4dannjjm 6686 32 young young JJ cord-023095-4dannjjm 6686 33 onset onset NN cord-023095-4dannjjm 6686 34 Leonbergers Leonbergers NNPS cord-023095-4dannjjm 6686 35 that that WDT cord-023095-4dannjjm 6686 36 are be VBP cord-023095-4dannjjm 6686 37 nerve nerve JJ cord-023095-4dannjjm 6686 38 biopsy biopsy NN cord-023095-4dannjjm 6686 39 positive positive JJ cord-023095-4dannjjm 6686 40 for for IN cord-023095-4dannjjm 6686 41 LPN LPN NNP cord-023095-4dannjjm 6686 42 , , , cord-023095-4dannjjm 6686 43 59.4 59.4 CD cord-023095-4dannjjm 6686 44 % % NN cord-023095-4dannjjm 6686 45 ( ( -LRB- cord-023095-4dannjjm 6686 46 19 19 CD cord-023095-4dannjjm 6686 47 of of IN cord-023095-4dannjjm 6686 48 32 32 CD cord-023095-4dannjjm 6686 49 ) ) -RRB- cord-023095-4dannjjm 6686 50 have have VBP cord-023095-4dannjjm 6686 51 two two CD cord-023095-4dannjjm 6686 52 copies copy NNS cord-023095-4dannjjm 6686 53 of of IN cord-023095-4dannjjm 6686 54 this this DT cord-023095-4dannjjm 6686 55 deletion deletion NN cord-023095-4dannjjm 6686 56 . . . cord-023095-4dannjjm 6687 1 Importantly importantly RB cord-023095-4dannjjm 6687 2 , , , cord-023095-4dannjjm 6687 3 nearly nearly RB cord-023095-4dannjjm 6687 4 all all DT cord-023095-4dannjjm 6687 5 dogs dog NNS cord-023095-4dannjjm 6687 6 carrying carry VBG cord-023095-4dannjjm 6687 7 two two CD cord-023095-4dannjjm 6687 8 copies copy NNS cord-023095-4dannjjm 6687 9 of of IN cord-023095-4dannjjm 6687 10 the the DT cord-023095-4dannjjm 6687 11 deletion deletion NN cord-023095-4dannjjm 6687 12 ( ( -LRB- cord-023095-4dannjjm 6687 13 32 32 CD cord-023095-4dannjjm 6687 14 of of IN cord-023095-4dannjjm 6687 15 34 34 CD cord-023095-4dannjjm 6687 16 or or CC cord-023095-4dannjjm 6687 17 94.1 94.1 CD cord-023095-4dannjjm 6687 18 % % NN cord-023095-4dannjjm 6687 19 ) ) -RRB- cord-023095-4dannjjm 6687 20 are be VBP cord-023095-4dannjjm 6687 21 affected affect VBN cord-023095-4dannjjm 6687 22 with with IN cord-023095-4dannjjm 6687 23 LPN LPN NNP cord-023095-4dannjjm 6687 24 by by IN cord-023095-4dannjjm 6687 25 the the DT cord-023095-4dannjjm 6687 26 age age NN cord-023095-4dannjjm 6687 27 of of IN cord-023095-4dannjjm 6687 28 4 4 CD cord-023095-4dannjjm 6687 29 years year NNS cord-023095-4dannjjm 6687 30 . . . cord-023095-4dannjjm 6688 1 The the DT cord-023095-4dannjjm 6688 2 Leonberger Leonberger NNP cord-023095-4dannjjm 6688 3 breed breed NN cord-023095-4dannjjm 6688 4 was be VBD cord-023095-4dannjjm 6688 5 generated generate VBN cord-023095-4dannjjm 6688 6 from from IN cord-023095-4dannjjm 6688 7 crossing cross VBG cord-023095-4dannjjm 6688 8 several several JJ cord-023095-4dannjjm 6688 9 breeds breed NNS cord-023095-4dannjjm 6688 10 , , , cord-023095-4dannjjm 6688 11 including include VBG cord-023095-4dannjjm 6688 12 the the DT cord-023095-4dannjjm 6688 13 St. St. NNP cord-023095-4dannjjm 6688 14 Bernard Bernard NNP cord-023095-4dannjjm 6688 15 , , , cord-023095-4dannjjm 6688 16 and and CC cord-023095-4dannjjm 6688 17 a a DT cord-023095-4dannjjm 6688 18 polyneuropathy polyneuropathy NN cord-023095-4dannjjm 6688 19 clinically clinically RB cord-023095-4dannjjm 6688 20 and and CC cord-023095-4dannjjm 6688 21 histologically histologically RB cord-023095-4dannjjm 6688 22 similar similar JJ cord-023095-4dannjjm 6688 23 to to IN cord-023095-4dannjjm 6688 24 LPN LPN NNP cord-023095-4dannjjm 6688 25 occurs occur VBZ cord-023095-4dannjjm 6688 26 in in IN cord-023095-4dannjjm 6688 27 this this DT cord-023095-4dannjjm 6688 28 breed breed NN cord-023095-4dannjjm 6688 29 . . . cord-023095-4dannjjm 6689 1 To to TO cord-023095-4dannjjm 6689 2 determine determine VB cord-023095-4dannjjm 6689 3 if if IN cord-023095-4dannjjm 6689 4 the the DT cord-023095-4dannjjm 6689 5 ARHGEF10 ARHGEF10 NNP cord-023095-4dannjjm 6689 6 mutation mutation NN cord-023095-4dannjjm 6689 7 was be VBD cord-023095-4dannjjm 6689 8 associated associate VBN cord-023095-4dannjjm 6689 9 with with IN cord-023095-4dannjjm 6689 10 polyneuropathy polyneuropathy NNS cord-023095-4dannjjm 6689 11 in in IN cord-023095-4dannjjm 6689 12 the the DT cord-023095-4dannjjm 6689 13 St. St. NNP cord-023095-4dannjjm 6689 14 Bernard Bernard NNP cord-023095-4dannjjm 6689 15 , , , cord-023095-4dannjjm 6689 16 DNA DNA NNP cord-023095-4dannjjm 6689 17 was be VBD cord-023095-4dannjjm 6689 18 extracted extract VBN cord-023095-4dannjjm 6689 19 from from IN cord-023095-4dannjjm 6689 20 archived archived JJ cord-023095-4dannjjm 6689 21 frozen frozen JJ cord-023095-4dannjjm 6689 22 muscle muscle NN cord-023095-4dannjjm 6689 23 biopsy biopsy NN cord-023095-4dannjjm 6689 24 specimens specimen NNS cord-023095-4dannjjm 6689 25 from from IN cord-023095-4dannjjm 6689 26 clinical clinical JJ cord-023095-4dannjjm 6689 27 cases case NNS cord-023095-4dannjjm 6689 28 ( ( -LRB- cord-023095-4dannjjm 6689 29 n n NN cord-023095-4dannjjm 6689 30 5 5 CD cord-023095-4dannjjm 6689 31 3 3 CD cord-023095-4dannjjm 6689 32 ) ) -RRB- cord-023095-4dannjjm 6689 33 . . . cord-023095-4dannjjm 6690 1 The the DT cord-023095-4dannjjm 6690 2 identical identical JJ cord-023095-4dannjjm 6690 3 ARHGEF10 arhgef10 NN cord-023095-4dannjjm 6690 4 Startle startle VB cord-023095-4dannjjm 6690 5 disease disease NN cord-023095-4dannjjm 6690 6 or or CC cord-023095-4dannjjm 6690 7 hyperekplexia hyperekplexia NN cord-023095-4dannjjm 6690 8 is be VBZ cord-023095-4dannjjm 6690 9 caused cause VBN cord-023095-4dannjjm 6690 10 by by IN cord-023095-4dannjjm 6690 11 defects defect NNS cord-023095-4dannjjm 6690 12 in in IN cord-023095-4dannjjm 6690 13 mammalian mammalian JJ cord-023095-4dannjjm 6690 14 glycinergic glycinergic JJ cord-023095-4dannjjm 6690 15 neurotransmission neurotransmission NN cord-023095-4dannjjm 6690 16 resulting result VBG cord-023095-4dannjjm 6690 17 in in IN cord-023095-4dannjjm 6690 18 an an DT cord-023095-4dannjjm 6690 19 exaggerated exaggerated JJ cord-023095-4dannjjm 6690 20 startle startle VB cord-023095-4dannjjm 6690 21 reflex reflex NN cord-023095-4dannjjm 6690 22 and and CC cord-023095-4dannjjm 6690 23 extensor extensor JJ cord-023095-4dannjjm 6690 24 hypertonia hypertonia NNP cord-023095-4dannjjm 6690 25 triggered trigger VBN cord-023095-4dannjjm 6690 26 by by IN cord-023095-4dannjjm 6690 27 noise noise NN cord-023095-4dannjjm 6690 28 or or CC cord-023095-4dannjjm 6690 29 touch touch NN cord-023095-4dannjjm 6690 30 . . . cord-023095-4dannjjm 6691 1 In in IN cord-023095-4dannjjm 6691 2 humans human NNS cord-023095-4dannjjm 6691 3 and and CC cord-023095-4dannjjm 6691 4 animals animal NNS cord-023095-4dannjjm 6691 5 , , , cord-023095-4dannjjm 6691 6 startle startle VB cord-023095-4dannjjm 6691 7 disease disease NN cord-023095-4dannjjm 6691 8 is be VBZ cord-023095-4dannjjm 6691 9 typically typically RB cord-023095-4dannjjm 6691 10 caused cause VBN cord-023095-4dannjjm 6691 11 by by IN cord-023095-4dannjjm 6691 12 mutations mutation NNS cord-023095-4dannjjm 6691 13 in in IN cord-023095-4dannjjm 6691 14 one one CD cord-023095-4dannjjm 6691 15 of of IN cord-023095-4dannjjm 6691 16 three three CD cord-023095-4dannjjm 6691 17 genes gene NNS cord-023095-4dannjjm 6691 18 ( ( -LRB- cord-023095-4dannjjm 6691 19 GLRA1 GLRA1 NNP cord-023095-4dannjjm 6691 20 , , , cord-023095-4dannjjm 6691 21 GLRB GLRB NNP cord-023095-4dannjjm 6691 22 , , , cord-023095-4dannjjm 6691 23 and and CC cord-023095-4dannjjm 6691 24 SLC6A5 slc6a5 NN cord-023095-4dannjjm 6691 25 ) ) -RRB- cord-023095-4dannjjm 6691 26 encoding encode VBG cord-023095-4dannjjm 6691 27 postsynaptic postsynaptic JJ cord-023095-4dannjjm 6691 28 glycine glycine NN cord-023095-4dannjjm 6691 29 receptor receptor NN cord-023095-4dannjjm 6691 30 subunits subunit NNS cord-023095-4dannjjm 6691 31 ( ( -LRB- cord-023095-4dannjjm 6691 32 a1 a1 NNP cord-023095-4dannjjm 6691 33 and and CC cord-023095-4dannjjm 6691 34 b b NNP cord-023095-4dannjjm 6691 35 ) ) -RRB- cord-023095-4dannjjm 6691 36 or or CC cord-023095-4dannjjm 6691 37 a a DT cord-023095-4dannjjm 6691 38 presynaptic presynaptic JJ cord-023095-4dannjjm 6691 39 glycine glycine NN cord-023095-4dannjjm 6691 40 transporter transporter NN cord-023095-4dannjjm 6691 41 ( ( -LRB- cord-023095-4dannjjm 6691 42 GlyT2 GlyT2 NNP cord-023095-4dannjjm 6691 43 ) ) -RRB- cord-023095-4dannjjm 6691 44 . . . cord-023095-4dannjjm 6692 1 A a DT cord-023095-4dannjjm 6692 2 litter litter NN cord-023095-4dannjjm 6692 3 of of IN cord-023095-4dannjjm 6692 4 seven seven CD cord-023095-4dannjjm 6692 5 Irish irish JJ cord-023095-4dannjjm 6692 6 Wolfhounds Wolfhounds NNPS cord-023095-4dannjjm 6692 7 was be VBD cord-023095-4dannjjm 6692 8 recently recently RB cord-023095-4dannjjm 6692 9 identified identify VBN cord-023095-4dannjjm 6692 10 in in IN cord-023095-4dannjjm 6692 11 which which WDT cord-023095-4dannjjm 6692 12 two two CD cord-023095-4dannjjm 6692 13 puppies puppy NNS cord-023095-4dannjjm 6692 14 developed develop VBD cord-023095-4dannjjm 6692 15 muscle muscle NN cord-023095-4dannjjm 6692 16 stiffness stiffness NN cord-023095-4dannjjm 6692 17 and and CC cord-023095-4dannjjm 6692 18 tremor tremor NN cord-023095-4dannjjm 6692 19 beginning begin VBG cord-023095-4dannjjm 6692 20 at at IN cord-023095-4dannjjm 6692 21 5 5 CD cord-023095-4dannjjm 6692 22 - - SYM cord-023095-4dannjjm 6692 23 7 7 CD cord-023095-4dannjjm 6692 24 days day NNS cord-023095-4dannjjm 6692 25 of of IN cord-023095-4dannjjm 6692 26 age age NN cord-023095-4dannjjm 6692 27 post post NN cord-023095-4dannjjm 6692 28 - - NN cord-023095-4dannjjm 6692 29 partum partum JJ cord-023095-4dannjjm 6692 30 . . . cord-023095-4dannjjm 6693 1 Signs sign NNS cord-023095-4dannjjm 6693 2 were be VBD cord-023095-4dannjjm 6693 3 dramatic dramatic JJ cord-023095-4dannjjm 6693 4 when when WRB cord-023095-4dannjjm 6693 5 the the DT cord-023095-4dannjjm 6693 6 puppies puppy NNS cord-023095-4dannjjm 6693 7 were be VBD cord-023095-4dannjjm 6693 8 handled handle VBN cord-023095-4dannjjm 6693 9 and and CC cord-023095-4dannjjm 6693 10 resolved resolve VBN cord-023095-4dannjjm 6693 11 when when WRB cord-023095-4dannjjm 6693 12 the the DT cord-023095-4dannjjm 6693 13 puppies puppy NNS cord-023095-4dannjjm 6693 14 were be VBD cord-023095-4dannjjm 6693 15 relaxed relaxed JJ cord-023095-4dannjjm 6693 16 or or CC cord-023095-4dannjjm 6693 17 sleeping sleep VBG cord-023095-4dannjjm 6693 18 . . . cord-023095-4dannjjm 6694 1 Both both DT cord-023095-4dannjjm 6694 2 puppies puppy NNS cord-023095-4dannjjm 6694 3 were be VBD cord-023095-4dannjjm 6694 4 euthanized euthanize VBN cord-023095-4dannjjm 6694 5 due due IN cord-023095-4dannjjm 6694 6 to to IN cord-023095-4dannjjm 6694 7 ongoing ongoing JJ cord-023095-4dannjjm 6694 8 stiffness stiffness NN cord-023095-4dannjjm 6694 9 , , , cord-023095-4dannjjm 6694 10 tremor tremor NN cord-023095-4dannjjm 6694 11 and and CC cord-023095-4dannjjm 6694 12 breathing breathing NN cord-023095-4dannjjm 6694 13 difficulties difficulty NNS cord-023095-4dannjjm 6694 14 . . . cord-023095-4dannjjm 6695 1 Necropsies Necropsies NNP cord-023095-4dannjjm 6695 2 were be VBD cord-023095-4dannjjm 6695 3 performed perform VBN cord-023095-4dannjjm 6695 4 , , , cord-023095-4dannjjm 6695 5 but but CC cord-023095-4dannjjm 6695 6 no no DT cord-023095-4dannjjm 6695 7 microscopic microscopic JJ cord-023095-4dannjjm 6695 8 pathological pathological JJ cord-023095-4dannjjm 6695 9 abnormalities abnormality NNS cord-023095-4dannjjm 6695 10 were be VBD cord-023095-4dannjjm 6695 11 identified identify VBN cord-023095-4dannjjm 6695 12 in in IN cord-023095-4dannjjm 6695 13 the the DT cord-023095-4dannjjm 6695 14 peripheral peripheral JJ cord-023095-4dannjjm 6695 15 or or CC cord-023095-4dannjjm 6695 16 central central JJ cord-023095-4dannjjm 6695 17 nervous nervous JJ cord-023095-4dannjjm 6695 18 system system NN cord-023095-4dannjjm 6695 19 . . . cord-023095-4dannjjm 6696 1 Based base VBN cord-023095-4dannjjm 6696 2 on on IN cord-023095-4dannjjm 6696 3 the the DT cord-023095-4dannjjm 6696 4 clinical clinical JJ cord-023095-4dannjjm 6696 5 signs sign NNS cord-023095-4dannjjm 6696 6 , , , cord-023095-4dannjjm 6696 7 exons exon NNS cord-023095-4dannjjm 6696 8 from from IN cord-023095-4dannjjm 6696 9 the the DT cord-023095-4dannjjm 6696 10 three three CD cord-023095-4dannjjm 6696 11 candidate candidate NN cord-023095-4dannjjm 6696 12 genes gene NNS cord-023095-4dannjjm 6696 13 were be VBD cord-023095-4dannjjm 6696 14 amplified amplify VBN cord-023095-4dannjjm 6696 15 from from IN cord-023095-4dannjjm 6696 16 genomic genomic JJ cord-023095-4dannjjm 6696 17 DNA dna NN cord-023095-4dannjjm 6696 18 isolated isolate VBN cord-023095-4dannjjm 6696 19 using use VBG cord-023095-4dannjjm 6696 20 PCR PCR NNP cord-023095-4dannjjm 6696 21 and and CC cord-023095-4dannjjm 6696 22 directly directly RB cord-023095-4dannjjm 6696 23 sequenced sequence VBN cord-023095-4dannjjm 6696 24 . . . cord-023095-4dannjjm 6697 1 No no DT cord-023095-4dannjjm 6697 2 deleterious deleterious JJ cord-023095-4dannjjm 6697 3 polymorphisms polymorphism NNS cord-023095-4dannjjm 6697 4 were be VBD cord-023095-4dannjjm 6697 5 identified identify VBN cord-023095-4dannjjm 6697 6 in in IN cord-023095-4dannjjm 6697 7 either either CC cord-023095-4dannjjm 6697 8 GLRA1 GLRA1 NNP cord-023095-4dannjjm 6697 9 or or CC cord-023095-4dannjjm 6697 10 GLRB GLRB NNP cord-023095-4dannjjm 6697 11 . . . cord-023095-4dannjjm 6698 1 However however RB cord-023095-4dannjjm 6698 2 , , , cord-023095-4dannjjm 6698 3 difficulties difficulty NNS cord-023095-4dannjjm 6698 4 were be VBD cord-023095-4dannjjm 6698 5 experienced experience VBN cord-023095-4dannjjm 6698 6 in in IN cord-023095-4dannjjm 6698 7 amplifying amplify VBG cord-023095-4dannjjm 6698 8 SLC6A5 SLC6A5 NNP cord-023095-4dannjjm 6698 9 exons exon NNS cord-023095-4dannjjm 6698 10 2 2 CD cord-023095-4dannjjm 6698 11 and and CC cord-023095-4dannjjm 6698 12 3 3 CD cord-023095-4dannjjm 6698 13 from from IN cord-023095-4dannjjm 6698 14 affected affected JJ cord-023095-4dannjjm 6698 15 animals animal NNS cord-023095-4dannjjm 6698 16 , , , cord-023095-4dannjjm 6698 17 although although IN cord-023095-4dannjjm 6698 18 control control NN cord-023095-4dannjjm 6698 19 samples sample NNS cord-023095-4dannjjm 6698 20 were be VBD cord-023095-4dannjjm 6698 21 positive positive JJ cord-023095-4dannjjm 6698 22 , , , cord-023095-4dannjjm 6698 23 suggesting suggest VBG cord-023095-4dannjjm 6698 24 that that IN cord-023095-4dannjjm 6698 25 the the DT cord-023095-4dannjjm 6698 26 PCR PCR NNP cord-023095-4dannjjm 6698 27 primer primer NN cord-023095-4dannjjm 6698 28 designs design NNS cord-023095-4dannjjm 6698 29 and and CC cord-023095-4dannjjm 6698 30 conditions condition NNS cord-023095-4dannjjm 6698 31 were be VBD cord-023095-4dannjjm 6698 32 not not RB cord-023095-4dannjjm 6698 33 at at IN cord-023095-4dannjjm 6698 34 fault fault NN cord-023095-4dannjjm 6698 35 . . . cord-023095-4dannjjm 6699 1 Further further JJ cord-023095-4dannjjm 6699 2 PCRs pcr NNS cord-023095-4dannjjm 6699 3 revealed reveal VBD cord-023095-4dannjjm 6699 4 that that IN cord-023095-4dannjjm 6699 5 the the DT cord-023095-4dannjjm 6699 6 reason reason NN cord-023095-4dannjjm 6699 7 for for IN cord-023095-4dannjjm 6699 8 this this DT cord-023095-4dannjjm 6699 9 anomaly anomaly NN cord-023095-4dannjjm 6699 10 was be VBD cord-023095-4dannjjm 6699 11 the the DT cord-023095-4dannjjm 6699 12 presence presence NN cord-023095-4dannjjm 6699 13 of of IN cord-023095-4dannjjm 6699 14 a a DT cord-023095-4dannjjm 6699 15 homozygous homozygous JJ cord-023095-4dannjjm 6699 16 4.2 4.2 CD cord-023095-4dannjjm 6699 17 kb kb NNP cord-023095-4dannjjm 6699 18 deletion deletion NN cord-023095-4dannjjm 6699 19 encompassing encompass VBG cord-023095-4dannjjm 6699 20 exons exon NNS cord-023095-4dannjjm 6699 21 2 2 CD cord-023095-4dannjjm 6699 22 and and CC cord-023095-4dannjjm 6699 23 3 3 CD cord-023095-4dannjjm 6699 24 of of IN cord-023095-4dannjjm 6699 25 the the DT cord-023095-4dannjjm 6699 26 GlyT2 GlyT2 NNP cord-023095-4dannjjm 6699 27 gene gene NN cord-023095-4dannjjm 6699 28 in in IN cord-023095-4dannjjm 6699 29 both both CC cord-023095-4dannjjm 6699 30 affected affect VBN cord-023095-4dannjjm 6699 31 animals animal NNS cord-023095-4dannjjm 6699 32 . . . cord-023095-4dannjjm 6700 1 This this DT cord-023095-4dannjjm 6700 2 deletion deletion NN cord-023095-4dannjjm 6700 3 is be VBZ cord-023095-4dannjjm 6700 4 predicted predict VBN cord-023095-4dannjjm 6700 5 to to TO cord-023095-4dannjjm 6700 6 result result VB cord-023095-4dannjjm 6700 7 in in IN cord-023095-4dannjjm 6700 8 the the DT cord-023095-4dannjjm 6700 9 loss loss NN cord-023095-4dannjjm 6700 10 of of IN cord-023095-4dannjjm 6700 11 part part NN cord-023095-4dannjjm 6700 12 of of IN cord-023095-4dannjjm 6700 13 the the DT cord-023095-4dannjjm 6700 14 large large JJ cord-023095-4dannjjm 6700 15 cytoplasmic cytoplasmic JJ cord-023095-4dannjjm 6700 16 N n NN cord-023095-4dannjjm 6700 17 - - HYPH cord-023095-4dannjjm 6700 18 terminus terminus NN cord-023095-4dannjjm 6700 19 that that WDT cord-023095-4dannjjm 6700 20 is be VBZ cord-023095-4dannjjm 6700 21 vital vital JJ cord-023095-4dannjjm 6700 22 for for IN cord-023095-4dannjjm 6700 23 trafficking trafficking NN cord-023095-4dannjjm 6700 24 of of IN cord-023095-4dannjjm 6700 25 GlyT2 GlyT2 NNP cord-023095-4dannjjm 6700 26 to to IN cord-023095-4dannjjm 6700 27 synaptic synaptic JJ cord-023095-4dannjjm 6700 28 sites site NNS cord-023095-4dannjjm 6700 29 , , , cord-023095-4dannjjm 6700 30 and and CC cord-023095-4dannjjm 6700 31 a a DT cord-023095-4dannjjm 6700 32 loss loss NN cord-023095-4dannjjm 6700 33 of of IN cord-023095-4dannjjm 6700 34 all all DT cord-023095-4dannjjm 6700 35 subsequent subsequent JJ cord-023095-4dannjjm 6700 36 transmembrane transmembrane NN cord-023095-4dannjjm 6700 37 domains domain NNS cord-023095-4dannjjm 6700 38 via via IN cord-023095-4dannjjm 6700 39 a a DT cord-023095-4dannjjm 6700 40 frameshift frameshift NN cord-023095-4dannjjm 6700 41 . . . cord-023095-4dannjjm 6701 1 This this DT cord-023095-4dannjjm 6701 2 genetic genetic JJ cord-023095-4dannjjm 6701 3 lesion lesion NN cord-023095-4dannjjm 6701 4 was be VBD cord-023095-4dannjjm 6701 5 confirmed confirm VBN cord-023095-4dannjjm 6701 6 by by IN cord-023095-4dannjjm 6701 7 defining define VBG cord-023095-4dannjjm 6701 8 the the DT cord-023095-4dannjjm 6701 9 deletion deletion NN cord-023095-4dannjjm 6701 10 breakpoint breakpoint NN cord-023095-4dannjjm 6701 11 , , , cord-023095-4dannjjm 6701 12 Southern southern JJ cord-023095-4dannjjm 6701 13 blotting blotting NN cord-023095-4dannjjm 6701 14 and and CC cord-023095-4dannjjm 6701 15 Multiplex Multiplex NNP cord-023095-4dannjjm 6701 16 Ligationdependent Ligationdependent NNP cord-023095-4dannjjm 6701 17 Probe Probe NNP cord-023095-4dannjjm 6701 18 Amplification Amplification NNP cord-023095-4dannjjm 6701 19 ( ( -LRB- cord-023095-4dannjjm 6701 20 MLPA MLPA NNP cord-023095-4dannjjm 6701 21 ) ) -RRB- cord-023095-4dannjjm 6701 22 . . . cord-023095-4dannjjm 6702 1 This this DT cord-023095-4dannjjm 6702 2 analysis analysis NN cord-023095-4dannjjm 6702 3 enabled enable VBD cord-023095-4dannjjm 6702 4 the the DT cord-023095-4dannjjm 6702 5 development development NN cord-023095-4dannjjm 6702 6 of of IN cord-023095-4dannjjm 6702 7 a a DT cord-023095-4dannjjm 6702 8 rapid rapid JJ cord-023095-4dannjjm 6702 9 genotyping genotyping NN cord-023095-4dannjjm 6702 10 test test NN cord-023095-4dannjjm 6702 11 that that WDT cord-023095-4dannjjm 6702 12 revealed reveal VBD cord-023095-4dannjjm 6702 13 heterozygosity heterozygosity NN cord-023095-4dannjjm 6702 14 for for IN cord-023095-4dannjjm 6702 15 the the DT cord-023095-4dannjjm 6702 16 deletion deletion NN cord-023095-4dannjjm 6702 17 in in IN cord-023095-4dannjjm 6702 18 the the DT cord-023095-4dannjjm 6702 19 dam dam NN cord-023095-4dannjjm 6702 20 and and CC cord-023095-4dannjjm 6702 21 sire sire JJ cord-023095-4dannjjm 6702 22 and and CC cord-023095-4dannjjm 6702 23 three three CD cord-023095-4dannjjm 6702 24 other other JJ cord-023095-4dannjjm 6702 25 siblings sibling NNS cord-023095-4dannjjm 6702 26 , , , cord-023095-4dannjjm 6702 27 suggesting suggest VBG cord-023095-4dannjjm 6702 28 recessive recessive JJ cord-023095-4dannjjm 6702 29 inheritance inheritance NN cord-023095-4dannjjm 6702 30 of of IN cord-023095-4dannjjm 6702 31 this this DT cord-023095-4dannjjm 6702 32 disorder disorder NN cord-023095-4dannjjm 6702 33 . . . cord-023095-4dannjjm 6703 1 Wider wide JJR cord-023095-4dannjjm 6703 2 testing testing NN cord-023095-4dannjjm 6703 3 of of IN cord-023095-4dannjjm 6703 4 related related JJ cord-023095-4dannjjm 6703 5 animals animal NNS cord-023095-4dannjjm 6703 6 has have VBZ cord-023095-4dannjjm 6703 7 identified identify VBN cord-023095-4dannjjm 6703 8 a a DT cord-023095-4dannjjm 6703 9 total total NN cord-023095-4dannjjm 6703 10 of of IN cord-023095-4dannjjm 6703 11 18 18 CD cord-023095-4dannjjm 6703 12 carriers carrier NNS cord-023095-4dannjjm 6703 13 of of IN cord-023095-4dannjjm 6703 14 the the DT cord-023095-4dannjjm 6703 15 SLC6A5 SLC6A5 NNP cord-023095-4dannjjm 6703 16 deletion deletion NN cord-023095-4dannjjm 6703 17 and and CC cord-023095-4dannjjm 6703 18 enabled enable VBD cord-023095-4dannjjm 6703 19 the the DT cord-023095-4dannjjm 6703 20 identification identification NN cord-023095-4dannjjm 6703 21 of of IN cord-023095-4dannjjm 6703 22 non non JJ cord-023095-4dannjjm 6703 23 - - JJ cord-023095-4dannjjm 6703 24 carrier carrier JJ cord-023095-4dannjjm 6703 25 animals animal NNS cord-023095-4dannjjm 6703 26 to to TO cord-023095-4dannjjm 6703 27 guide guide VB cord-023095-4dannjjm 6703 28 future future JJ cord-023095-4dannjjm 6703 29 breeding breeding NN cord-023095-4dannjjm 6703 30 strategies strategy NNS cord-023095-4dannjjm 6703 31 . . . cord-023095-4dannjjm 6704 1 Insulin insulin NN cord-023095-4dannjjm 6704 2 resistance resistance NN cord-023095-4dannjjm 6704 3 ( ( -LRB- cord-023095-4dannjjm 6704 4 IR IR NNP cord-023095-4dannjjm 6704 5 ) ) -RRB- cord-023095-4dannjjm 6704 6 , , , cord-023095-4dannjjm 6704 7 obesity obesity NN cord-023095-4dannjjm 6704 8 , , , cord-023095-4dannjjm 6704 9 and and CC cord-023095-4dannjjm 6704 10 type type NN cord-023095-4dannjjm 6704 11 2 2 CD cord-023095-4dannjjm 6704 12 diabetes diabetes NN cord-023095-4dannjjm 6704 13 affect affect VBP cord-023095-4dannjjm 6704 14 glucagon glucagon NN cord-023095-4dannjjm 6704 15 - - HYPH cord-023095-4dannjjm 6704 16 like like JJ cord-023095-4dannjjm 6704 17 peptide peptide NN cord-023095-4dannjjm 6704 18 1 1 CD cord-023095-4dannjjm 6704 19 ( ( -LRB- cord-023095-4dannjjm 6704 20 GLP-1 GLP-1 NNP cord-023095-4dannjjm 6704 21 ) ) -RRB- cord-023095-4dannjjm 6704 22 concentrations concentration NNS cord-023095-4dannjjm 6704 23 in in IN cord-023095-4dannjjm 6704 24 humans human NNS cord-023095-4dannjjm 6704 25 and and CC cord-023095-4dannjjm 6704 26 rodents rodent NNS cord-023095-4dannjjm 6704 27 , , , cord-023095-4dannjjm 6704 28 but but CC cord-023095-4dannjjm 6704 29 this this DT cord-023095-4dannjjm 6704 30 incretin incretin NNP cord-023095-4dannjjm 6704 31 hormone hormone NN cord-023095-4dannjjm 6704 32 has have VBZ cord-023095-4dannjjm 6704 33 not not RB cord-023095-4dannjjm 6704 34 been be VBN cord-023095-4dannjjm 6704 35 examined examine VBN cord-023095-4dannjjm 6704 36 in in IN cord-023095-4dannjjm 6704 37 horses horse NNS cord-023095-4dannjjm 6704 38 . . . cord-023095-4dannjjm 6705 1 We -PRON- PRP cord-023095-4dannjjm 6705 2 therefore therefore RB cord-023095-4dannjjm 6705 3 hypothesized hypothesize VBD cord-023095-4dannjjm 6705 4 that that IN cord-023095-4dannjjm 6705 5 GLP-1 glp-1 JJ cord-023095-4dannjjm 6705 6 concentrations concentration NNS cord-023095-4dannjjm 6705 7 would would MD cord-023095-4dannjjm 6705 8 change change VB cord-023095-4dannjjm 6705 9 in in IN cord-023095-4dannjjm 6705 10 horses horse NNS cord-023095-4dannjjm 6705 11 as as IN cord-023095-4dannjjm 6705 12 obesity obesity NN cord-023095-4dannjjm 6705 13 and and CC cord-023095-4dannjjm 6705 14 IR IR NNP cord-023095-4dannjjm 6705 15 were be VBD cord-023095-4dannjjm 6705 16 induced induce VBN cord-023095-4dannjjm 6705 17 or or CC cord-023095-4dannjjm 6705 18 exacerbated exacerbate VBN cord-023095-4dannjjm 6705 19 by by IN cord-023095-4dannjjm 6705 20 overfeeding overfeed VBG cord-023095-4dannjjm 6705 21 . . . cord-023095-4dannjjm 6706 1 Six six CD cord-023095-4dannjjm 6706 2 horses horse NNS cord-023095-4dannjjm 6706 3 previously previously RB cord-023095-4dannjjm 6706 4 diagnosed diagnose VBN cord-023095-4dannjjm 6706 5 with with IN cord-023095-4dannjjm 6706 6 Equine Equine NNP cord-023095-4dannjjm 6706 7 Metabolic Metabolic NNP cord-023095-4dannjjm 6706 8 Syndrome Syndrome NNP cord-023095-4dannjjm 6706 9 were be VBD cord-023095-4dannjjm 6706 10 provided provide VBN cord-023095-4dannjjm 6706 11 with with IN cord-023095-4dannjjm 6706 12 twice twice PDT cord-023095-4dannjjm 6706 13 the the DT cord-023095-4dannjjm 6706 14 amount amount NN cord-023095-4dannjjm 6706 15 of of IN cord-023095-4dannjjm 6706 16 digestible digestible JJ cord-023095-4dannjjm 6706 17 energy energy NN cord-023095-4dannjjm 6706 18 required require VBN cord-023095-4dannjjm 6706 19 for for IN cord-023095-4dannjjm 6706 20 maintenance maintenance NN cord-023095-4dannjjm 6706 21 as as IN cord-023095-4dannjjm 6706 22 sweet sweet JJ cord-023095-4dannjjm 6706 23 feed feed NN cord-023095-4dannjjm 6706 24 and and CC cord-023095-4dannjjm 6706 25 hay hay NN cord-023095-4dannjjm 6706 26 for for IN cord-023095-4dannjjm 6706 27 8 8 CD cord-023095-4dannjjm 6706 28 weeks week NNS cord-023095-4dannjjm 6706 29 . . . cord-023095-4dannjjm 6707 1 Intravenous intravenous JJ cord-023095-4dannjjm 6707 2 and and CC cord-023095-4dannjjm 6707 3 oral oral JJ cord-023095-4dannjjm 6707 4 glucose glucose NN cord-023095-4dannjjm 6707 5 tolerance tolerance NN cord-023095-4dannjjm 6707 6 tests test NNS cord-023095-4dannjjm 6707 7 ( ( -LRB- cord-023095-4dannjjm 6707 8 OGTTs OGTTs NNP cord-023095-4dannjjm 6707 9 ) ) -RRB- cord-023095-4dannjjm 6707 10 were be VBD cord-023095-4dannjjm 6707 11 performed perform VBN cord-023095-4dannjjm 6707 12 at at IN cord-023095-4dannjjm 6707 13 0 0 CD cord-023095-4dannjjm 6707 14 and and CC cord-023095-4dannjjm 6707 15 8 8 CD cord-023095-4dannjjm 6707 16 weeks week NNS cord-023095-4dannjjm 6707 17 . . . cord-023095-4dannjjm 6708 1 Effects effect NNS cord-023095-4dannjjm 6708 2 of of IN cord-023095-4dannjjm 6708 3 time time NN cord-023095-4dannjjm 6708 4 and and CC cord-023095-4dannjjm 6708 5 period period NN cord-023095-4dannjjm 6708 6 ( ( -LRB- cord-023095-4dannjjm 6708 7 0 0 CD cord-023095-4dannjjm 6708 8 and and CC cord-023095-4dannjjm 6708 9 8 8 CD cord-023095-4dannjjm 6708 10 weeks week NNS cord-023095-4dannjjm 6708 11 ) ) -RRB- cord-023095-4dannjjm 6708 12 were be VBD cord-023095-4dannjjm 6708 13 assessed assess VBN cord-023095-4dannjjm 6708 14 by by IN cord-023095-4dannjjm 6708 15 repeated repeat VBN cord-023095-4dannjjm 6708 16 measures measure NNS cord-023095-4dannjjm 6708 17 ANOVA.Mean ANOVA.Mean NNP cord-023095-4dannjjm 6708 18 body body NN cord-023095-4dannjjm 6708 19 weight weight NN cord-023095-4dannjjm 6708 20 increased increase VBD cord-023095-4dannjjm 6708 21 from from IN cord-023095-4dannjjm 6708 22 438 438 CD cord-023095-4dannjjm 6708 23 AE AE NNP cord-023095-4dannjjm 6708 24 61 61 CD cord-023095-4dannjjm 6708 25 kg kg NN cord-023095-4dannjjm 6708 26 ( ( -LRB- cord-023095-4dannjjm 6708 27 range range NN cord-023095-4dannjjm 6708 28 , , , cord-023095-4dannjjm 6708 29 381 381 CD cord-023095-4dannjjm 6708 30 to to TO cord-023095-4dannjjm 6708 31 533 533 CD cord-023095-4dannjjm 6708 32 kg kg NNS cord-023095-4dannjjm 6708 33 ) ) -RRB- cord-023095-4dannjjm 6708 34 to to IN cord-023095-4dannjjm 6708 35 464 464 CD cord-023095-4dannjjm 6708 36 AE AE NNP cord-023095-4dannjjm 6708 37 61 61 CD cord-023095-4dannjjm 6708 38 kg kg NN cord-023095-4dannjjm 6708 39 ( ( -LRB- cord-023095-4dannjjm 6708 40 range range NN cord-023095-4dannjjm 6708 41 , , , cord-023095-4dannjjm 6708 42 394 394 CD cord-023095-4dannjjm 6708 43 to to TO cord-023095-4dannjjm 6708 44 550 550 CD cord-023095-4dannjjm 6708 45 kg kg NNS cord-023095-4dannjjm 6708 46 ) ) -RRB- cord-023095-4dannjjm 6708 47 over over IN cord-023095-4dannjjm 6708 48 8 8 CD cord-023095-4dannjjm 6708 49 weeks week NNS cord-023095-4dannjjm 6708 50 , , , cord-023095-4dannjjm 6708 51 with with IN cord-023095-4dannjjm 6708 52 individual individual JJ cord-023095-4dannjjm 6708 53 horse horse NN cord-023095-4dannjjm 6708 54 weight weight NN cord-023095-4dannjjm 6708 55 gain gain NN cord-023095-4dannjjm 6708 56 varying vary VBG cord-023095-4dannjjm 6708 57 from from IN cord-023095-4dannjjm 6708 58 2 2 CD cord-023095-4dannjjm 6708 59 to to TO cord-023095-4dannjjm 6708 60 10 10 CD cord-023095-4dannjjm 6708 61 % % NN cord-023095-4dannjjm 6708 62 . . . cord-023095-4dannjjm 6709 1 Mean mean JJ cord-023095-4dannjjm 6709 2 body body NN cord-023095-4dannjjm 6709 3 condition condition NN cord-023095-4dannjjm 6709 4 score score NN cord-023095-4dannjjm 6709 5 increased increase VBD cord-023095-4dannjjm 6709 6 ( ( -LRB- cord-023095-4dannjjm 6709 7 P p NN cord-023095-4dannjjm 6709 8 5 5 CD cord-023095-4dannjjm 6709 9 0.006 0.006 CD cord-023095-4dannjjm 6709 10 ) ) -RRB- cord-023095-4dannjjm 6709 11 from from IN cord-023095-4dannjjm 6709 12 6 6 CD cord-023095-4dannjjm 6709 13 AE AE NNP cord-023095-4dannjjm 6709 14 2 2 CD cord-023095-4dannjjm 6709 15 ( ( -LRB- cord-023095-4dannjjm 6709 16 range range NN cord-023095-4dannjjm 6709 17 , , , cord-023095-4dannjjm 6709 18 4 4 CD cord-023095-4dannjjm 6709 19 to to IN cord-023095-4dannjjm 6709 20 8.5 8.5 CD cord-023095-4dannjjm 6709 21 ) ) -RRB- cord-023095-4dannjjm 6709 22 to to IN cord-023095-4dannjjm 6709 23 8 8 CD cord-023095-4dannjjm 6709 24 AE AE NNP cord-023095-4dannjjm 6709 25 1 1 CD cord-023095-4dannjjm 6709 26 ( ( -LRB- cord-023095-4dannjjm 6709 27 range range NN cord-023095-4dannjjm 6709 28 , , , cord-023095-4dannjjm 6709 29 7 7 CD cord-023095-4dannjjm 6709 30 to to TO cord-023095-4dannjjm 6709 31 9 9 CD cord-023095-4dannjjm 6709 32 ) ) -RRB- cord-023095-4dannjjm 6709 33 . . . cord-023095-4dannjjm 6710 1 Three three CD cord-023095-4dannjjm 6710 2 horses horse NNS cord-023095-4dannjjm 6710 3 developed develop VBD cord-023095-4dannjjm 6710 4 mild mild JJ cord-023095-4dannjjm 6710 5 laminitis laminitis NN cord-023095-4dannjjm 6710 6 . . . cord-023095-4dannjjm 6711 1 Glucagon Glucagon NNP cord-023095-4dannjjm 6711 2 - - HYPH cord-023095-4dannjjm 6711 3 like like JJ cord-023095-4dannjjm 6711 4 peptide peptide NN cord-023095-4dannjjm 6711 5 1 1 CD cord-023095-4dannjjm 6711 6 concentrations concentration NNS cord-023095-4dannjjm 6711 7 increased increase VBD cord-023095-4dannjjm 6711 8 over over IN cord-023095-4dannjjm 6711 9 time time NN cord-023095-4dannjjm 6711 10 during during IN cord-023095-4dannjjm 6711 11 OGTTs ogtt NNS cord-023095-4dannjjm 6711 12 ( ( -LRB- cord-023095-4dannjjm 6711 13 P p NN cord-023095-4dannjjm 6711 14 5 5 CD cord-023095-4dannjjm 6711 15 0.023 0.023 CD cord-023095-4dannjjm 6711 16 ) ) -RRB- cord-023095-4dannjjm 6711 17 , , , cord-023095-4dannjjm 6711 18 but but CC cord-023095-4dannjjm 6711 19 the the DT cord-023095-4dannjjm 6711 20 period period NN cord-023095-4dannjjm 6711 21 Â â CD cord-023095-4dannjjm 6711 22 time time NN cord-023095-4dannjjm 6711 23 effect effect NN cord-023095-4dannjjm 6711 24 was be VBD cord-023095-4dannjjm 6711 25 not not RB cord-023095-4dannjjm 6711 26 significant significant JJ cord-023095-4dannjjm 6712 1 ( ( -LRB- cord-023095-4dannjjm 6712 2 P p NN cord-023095-4dannjjm 6712 3 5 5 CD cord-023095-4dannjjm 6712 4 0.141 0.141 CD cord-023095-4dannjjm 6712 5 ) ) -RRB- cord-023095-4dannjjm 6712 6 . . . cord-023095-4dannjjm 6713 1 Area area NN cord-023095-4dannjjm 6713 2 under under IN cord-023095-4dannjjm 6713 3 the the DT cord-023095-4dannjjm 6713 4 GLP-1 glp-1 JJ cord-023095-4dannjjm 6713 5 curve curve NN cord-023095-4dannjjm 6713 6 remained remain VBD cord-023095-4dannjjm 6713 7 unaffected unaffected JJ cord-023095-4dannjjm 6713 8 by by IN cord-023095-4dannjjm 6713 9 weight weight NN cord-023095-4dannjjm 6713 10 gain gain NN cord-023095-4dannjjm 6713 11 , , , cord-023095-4dannjjm 6713 12 whereas whereas IN cord-023095-4dannjjm 6713 13 area area NN cord-023095-4dannjjm 6713 14 under under IN cord-023095-4dannjjm 6713 15 the the DT cord-023095-4dannjjm 6713 16 insulin insulin NN cord-023095-4dannjjm 6713 17 curve curve NN cord-023095-4dannjjm 6713 18 increased increase VBD cord-023095-4dannjjm 6713 19 ( ( -LRB- cord-023095-4dannjjm 6713 20 P p NN cord-023095-4dannjjm 6713 21 5 5 CD cord-023095-4dannjjm 6713 22 0.003 0.003 CD cord-023095-4dannjjm 6713 23 ) ) -RRB- cord-023095-4dannjjm 6713 24 over over IN cord-023095-4dannjjm 6713 25 time time NN cord-023095-4dannjjm 6713 26 , , , cord-023095-4dannjjm 6713 27 indicating indicate VBG cord-023095-4dannjjm 6713 28 a a DT cord-023095-4dannjjm 6713 29 reduction reduction NN cord-023095-4dannjjm 6713 30 in in IN cord-023095-4dannjjm 6713 31 insulin insulin NN cord-023095-4dannjjm 6713 32 sensitivity sensitivity NN cord-023095-4dannjjm 6713 33 . . . cord-023095-4dannjjm 6714 1 Obesity obesity NN cord-023095-4dannjjm 6714 2 and and CC cord-023095-4dannjjm 6714 3 IR IR NNP cord-023095-4dannjjm 6714 4 were be VBD cord-023095-4dannjjm 6714 5 induced induce VBN cord-023095-4dannjjm 6714 6 or or CC cord-023095-4dannjjm 6714 7 exacerbated exacerbate VBN cord-023095-4dannjjm 6714 8 when when WRB cord-023095-4dannjjm 6714 9 horses horse NNS cord-023095-4dannjjm 6714 10 previously previously RB cord-023095-4dannjjm 6714 11 diagnosed diagnose VBN cord-023095-4dannjjm 6714 12 with with IN cord-023095-4dannjjm 6714 13 EMS EMS NNP cord-023095-4dannjjm 6714 14 were be VBD cord-023095-4dannjjm 6714 15 overfed overfed JJ cord-023095-4dannjjm 6714 16 , , , cord-023095-4dannjjm 6714 17 but but CC cord-023095-4dannjjm 6714 18 GLP-1 glp-1 JJ cord-023095-4dannjjm 6714 19 concentrations concentration NNS cord-023095-4dannjjm 6714 20 did do VBD cord-023095-4dannjjm 6714 21 not not RB cord-023095-4dannjjm 6714 22 change change VB cord-023095-4dannjjm 6714 23 as as IN cord-023095-4dannjjm 6714 24 a a DT cord-023095-4dannjjm 6714 25 result result NN cord-023095-4dannjjm 6714 26 . . . cord-023095-4dannjjm 6715 1 Hypertonic Hypertonic NNP cord-023095-4dannjjm 6715 2 saline saline NN cord-023095-4dannjjm 6715 3 solution solution NN cord-023095-4dannjjm 6715 4 ( ( -LRB- cord-023095-4dannjjm 6715 5 7.2 7.2 CD cord-023095-4dannjjm 6715 6 % % NN cord-023095-4dannjjm 6715 7 ) ) -RRB- cord-023095-4dannjjm 6715 8 ( ( -LRB- cord-023095-4dannjjm 6715 9 HSS HSS NNP cord-023095-4dannjjm 6715 10 ) ) -RRB- cord-023095-4dannjjm 6715 11 is be VBZ cord-023095-4dannjjm 6715 12 an an DT cord-023095-4dannjjm 6715 13 intravenous intravenous JJ cord-023095-4dannjjm 6715 14 fluid fluid NN cord-023095-4dannjjm 6715 15 used use VBN cord-023095-4dannjjm 6715 16 for for IN cord-023095-4dannjjm 6715 17 the the DT cord-023095-4dannjjm 6715 18 emergency emergency NN cord-023095-4dannjjm 6715 19 treatment treatment NN cord-023095-4dannjjm 6715 20 of of IN cord-023095-4dannjjm 6715 21 intravascular intravascular JJ cord-023095-4dannjjm 6715 22 volume volume NN cord-023095-4dannjjm 6715 23 deficits deficit NNS cord-023095-4dannjjm 6715 24 . . . cord-023095-4dannjjm 6716 1 The the DT cord-023095-4dannjjm 6716 2 use use NN cord-023095-4dannjjm 6716 3 of of IN cord-023095-4dannjjm 6716 4 this this DT cord-023095-4dannjjm 6716 5 fluid fluid NN cord-023095-4dannjjm 6716 6 in in IN cord-023095-4dannjjm 6716 7 horses horse NNS cord-023095-4dannjjm 6716 8 with with IN cord-023095-4dannjjm 6716 9 severe severe JJ cord-023095-4dannjjm 6716 10 dehydration dehydration NN cord-023095-4dannjjm 6716 11 is be VBZ cord-023095-4dannjjm 6716 12 controversial controversial JJ cord-023095-4dannjjm 6716 13 . . . cord-023095-4dannjjm 6717 1 The the DT cord-023095-4dannjjm 6717 2 purpose purpose NN cord-023095-4dannjjm 6717 3 of of IN cord-023095-4dannjjm 6717 4 this this DT cord-023095-4dannjjm 6717 5 study study NN cord-023095-4dannjjm 6717 6 was be VBD cord-023095-4dannjjm 6717 7 to to TO cord-023095-4dannjjm 6717 8 compare compare VB cord-023095-4dannjjm 6717 9 the the DT cord-023095-4dannjjm 6717 10 use use NN cord-023095-4dannjjm 6717 11 of of IN cord-023095-4dannjjm 6717 12 HSS hss NN cord-023095-4dannjjm 6717 13 and and CC cord-023095-4dannjjm 6717 14 isotonic isotonic JJ cord-023095-4dannjjm 6717 15 saline saline NN cord-023095-4dannjjm 6717 16 solution solution NN cord-023095-4dannjjm 6717 17 ( ( -LRB- cord-023095-4dannjjm 6717 18 0.9 0.9 CD cord-023095-4dannjjm 6717 19 % % NN cord-023095-4dannjjm 6717 20 ) ) -RRB- cord-023095-4dannjjm 6718 1 ( ( -LRB- cord-023095-4dannjjm 6718 2 ISS ISS NNP cord-023095-4dannjjm 6718 3 ) ) -RRB- cord-023095-4dannjjm 6718 4 for for IN cord-023095-4dannjjm 6718 5 the the DT cord-023095-4dannjjm 6718 6 emergency emergency NN cord-023095-4dannjjm 6718 7 treatment treatment NN cord-023095-4dannjjm 6718 8 of of IN cord-023095-4dannjjm 6718 9 endurance endurance NN cord-023095-4dannjjm 6718 10 horses horse NNS cord-023095-4dannjjm 6718 11 . . . cord-023095-4dannjjm 6719 1 Endurance endurance NN cord-023095-4dannjjm 6719 2 horses horse NNS cord-023095-4dannjjm 6719 3 eliminated eliminate VBN cord-023095-4dannjjm 6719 4 from from IN cord-023095-4dannjjm 6719 5 competition competition NN cord-023095-4dannjjm 6719 6 and and CC cord-023095-4dannjjm 6719 7 requiring require VBG cord-023095-4dannjjm 6719 8 intravenous intravenous JJ cord-023095-4dannjjm 6719 9 fluid fluid NN cord-023095-4dannjjm 6719 10 therapy therapy NN cord-023095-4dannjjm 6719 11 were be VBD cord-023095-4dannjjm 6719 12 eligible eligible JJ cord-023095-4dannjjm 6719 13 for for IN cord-023095-4dannjjm 6719 14 enrollment enrollment NN cord-023095-4dannjjm 6719 15 in in IN cord-023095-4dannjjm 6719 16 the the DT cord-023095-4dannjjm 6719 17 study study NN cord-023095-4dannjjm 6719 18 . . . cord-023095-4dannjjm 6720 1 Twenty twenty CD cord-023095-4dannjjm 6720 2 - - HYPH cord-023095-4dannjjm 6720 3 two two CD cord-023095-4dannjjm 6720 4 horses horse NNS cord-023095-4dannjjm 6720 5 were be VBD cord-023095-4dannjjm 6720 6 randomly randomly RB cord-023095-4dannjjm 6720 7 assigned assign VBN cord-023095-4dannjjm 6720 8 to to TO cord-023095-4dannjjm 6720 9 receive receive VB cord-023095-4dannjjm 6720 10 4 4 CD cord-023095-4dannjjm 6720 11 ml ml NNS cord-023095-4dannjjm 6720 12 / / SYM cord-023095-4dannjjm 6720 13 kg kg NNS cord-023095-4dannjjm 6720 14 of of IN cord-023095-4dannjjm 6720 15 either either DT cord-023095-4dannjjm 6720 16 HSS HSS NNP cord-023095-4dannjjm 6720 17 or or CC cord-023095-4dannjjm 6720 18 ISS ISS NNP cord-023095-4dannjjm 6720 19 along along IN cord-023095-4dannjjm 6720 20 with with IN cord-023095-4dannjjm 6720 21 5 5 CD cord-023095-4dannjjm 6720 22 L l NN cord-023095-4dannjjm 6720 23 lactate lactate NN cord-023095-4dannjjm 6720 24 Ringer Ringer NNP cord-023095-4dannjjm 6720 25 's 's POS cord-023095-4dannjjm 6720 26 solution solution NN cord-023095-4dannjjm 6720 27 ( ( -LRB- cord-023095-4dannjjm 6720 28 LRS LRS NNP cord-023095-4dannjjm 6720 29 ) ) -RRB- cord-023095-4dannjjm 6720 30 . . . cord-023095-4dannjjm 6721 1 Following follow VBG cord-023095-4dannjjm 6721 2 this this DT cord-023095-4dannjjm 6721 3 bolus bolus NN cord-023095-4dannjjm 6721 4 , , , cord-023095-4dannjjm 6721 5 all all DT cord-023095-4dannjjm 6721 6 horses horse NNS cord-023095-4dannjjm 6721 7 were be VBD cord-023095-4dannjjm 6721 8 treated treat VBN cord-023095-4dannjjm 6721 9 with with IN cord-023095-4dannjjm 6721 10 an an DT cord-023095-4dannjjm 6721 11 additional additional JJ cord-023095-4dannjjm 6721 12 10L 10l NN cord-023095-4dannjjm 6721 13 of of IN cord-023095-4dannjjm 6721 14 LRS LRS NNP cord-023095-4dannjjm 6721 15 . . . cord-023095-4dannjjm 6722 1 Blood blood NN cord-023095-4dannjjm 6722 2 and and CC cord-023095-4dannjjm 6722 3 urine urine NN cord-023095-4dannjjm 6722 4 samples sample NNS cord-023095-4dannjjm 6722 5 were be VBD cord-023095-4dannjjm 6722 6 collected collect VBN cord-023095-4dannjjm 6722 7 before before RB cord-023095-4dannjjm 6722 8 , , , cord-023095-4dannjjm 6722 9 during during IN cord-023095-4dannjjm 6722 10 and and CC cord-023095-4dannjjm 6722 11 after after IN cord-023095-4dannjjm 6722 12 treatment treatment NN cord-023095-4dannjjm 6722 13 . . . cord-023095-4dannjjm 6723 1 Data datum NNS cord-023095-4dannjjm 6723 2 was be VBD cord-023095-4dannjjm 6723 3 compared compare VBN cord-023095-4dannjjm 6723 4 using use VBG cord-023095-4dannjjm 6723 5 two two CD cord-023095-4dannjjm 6723 6 - - HYPH cord-023095-4dannjjm 6723 7 way way NN cord-023095-4dannjjm 6723 8 ANOVA anova NN cord-023095-4dannjjm 6723 9 with with IN cord-023095-4dannjjm 6723 10 repeated repeat VBN cord-023095-4dannjjm 6723 11 measures measure NNS cord-023095-4dannjjm 6723 12 . . . cord-023095-4dannjjm 6724 1 As as IN cord-023095-4dannjjm 6724 2 compared compare VBN cord-023095-4dannjjm 6724 3 to to IN cord-023095-4dannjjm 6724 4 ISS ISS NNP cord-023095-4dannjjm 6724 5 , , , cord-023095-4dannjjm 6724 6 HSS HSS NNP cord-023095-4dannjjm 6724 7 horses horse NNS cord-023095-4dannjjm 6724 8 showed show VBD cord-023095-4dannjjm 6724 9 a a DT cord-023095-4dannjjm 6724 10 greater great JJR cord-023095-4dannjjm 6724 11 decrease decrease NN cord-023095-4dannjjm 6724 12 in in IN cord-023095-4dannjjm 6724 13 PCV pcv NN cord-023095-4dannjjm 6724 14 ( ( -LRB- cord-023095-4dannjjm 6724 15 p p NN cord-023095-4dannjjm 6724 16 5 5 CD cord-023095-4dannjjm 6724 17 0.04 0.04 CD cord-023095-4dannjjm 6724 18 ) ) -RRB- cord-023095-4dannjjm 6724 19 , , , cord-023095-4dannjjm 6724 20 total total JJ cord-023095-4dannjjm 6724 21 protein protein NN cord-023095-4dannjjm 6724 22 ( ( -LRB- cord-023095-4dannjjm 6724 23 p p NN cord-023095-4dannjjm 6724 24 5 5 CD cord-023095-4dannjjm 6724 25 0.01 0.01 CD cord-023095-4dannjjm 6724 26 ) ) -RRB- cord-023095-4dannjjm 6724 27 , , , cord-023095-4dannjjm 6724 28 albumin albumin NN cord-023095-4dannjjm 6724 29 ( ( -LRB- cord-023095-4dannjjm 6724 30 p p NN cord-023095-4dannjjm 6724 31 5 5 CD cord-023095-4dannjjm 6724 32 0.01 0.01 CD cord-023095-4dannjjm 6724 33 ) ) -RRB- cord-023095-4dannjjm 6724 34 , , , cord-023095-4dannjjm 6724 35 and and CC cord-023095-4dannjjm 6724 36 globulin globulin NN cord-023095-4dannjjm 6724 37 ( ( -LRB- cord-023095-4dannjjm 6724 38 p p NN cord-023095-4dannjjm 6724 39 5 5 CD cord-023095-4dannjjm 6724 40 0.02 0.02 CD cord-023095-4dannjjm 6724 41 ) ) -RRB- cord-023095-4dannjjm 6724 42 . . . cord-023095-4dannjjm 6725 1 HSS HSS NNP cord-023095-4dannjjm 6725 2 horses horse NNS cord-023095-4dannjjm 6725 3 showed show VBD cord-023095-4dannjjm 6725 4 a a DT cord-023095-4dannjjm 6725 5 greater great JJR cord-023095-4dannjjm 6725 6 increase increase NN cord-023095-4dannjjm 6725 7 in in IN cord-023095-4dannjjm 6725 8 sodium sodium NN cord-023095-4dannjjm 6725 9 and and CC cord-023095-4dannjjm 6725 10 chloride chloride NN cord-023095-4dannjjm 6725 11 ( ( -LRB- cord-023095-4dannjjm 6725 12 p p NN cord-023095-4dannjjm 6725 13 o o NN cord-023095-4dannjjm 6725 14 0.001 0.001 CD cord-023095-4dannjjm 6725 15 ) ) -RRB- cord-023095-4dannjjm 6725 16 as as IN cord-023095-4dannjjm 6725 17 compared compare VBN cord-023095-4dannjjm 6725 18 to to IN cord-023095-4dannjjm 6725 19 ISS ISS NNP cord-023095-4dannjjm 6725 20 horses horse NNS cord-023095-4dannjjm 6725 21 . . . cord-023095-4dannjjm 6726 1 Horses horse NNS cord-023095-4dannjjm 6726 2 receiving receive VBG cord-023095-4dannjjm 6726 3 HSS HSS NNP cord-023095-4dannjjm 6726 4 had have VBD cord-023095-4dannjjm 6726 5 a a DT cord-023095-4dannjjm 6726 6 shorter short JJR cord-023095-4dannjjm 6726 7 time time NN cord-023095-4dannjjm 6726 8 to to IN cord-023095-4dannjjm 6726 9 urination urination NN cord-023095-4dannjjm 6726 10 ( ( -LRB- cord-023095-4dannjjm 6726 11 p p NN cord-023095-4dannjjm 6726 12 5 5 CD cord-023095-4dannjjm 6726 13 0.03 0.03 CD cord-023095-4dannjjm 6726 14 ) ) -RRB- cord-023095-4dannjjm 6726 15 and and CC cord-023095-4dannjjm 6726 16 lower lower VB cord-023095-4dannjjm 6726 17 specific specific JJ cord-023095-4dannjjm 6726 18 gravity gravity NN cord-023095-4dannjjm 6726 19 ( ( -LRB- cord-023095-4dannjjm 6726 20 p p NN cord-023095-4dannjjm 6726 21 o o NN cord-023095-4dannjjm 6726 22 0.001 0.001 CD cord-023095-4dannjjm 6726 23 ) ) -RRB- cord-023095-4dannjjm 6726 24 than than IN cord-023095-4dannjjm 6726 25 those those DT cord-023095-4dannjjm 6726 26 receiving receive VBG cord-023095-4dannjjm 6726 27 ISS.Results iss.results XX cord-023095-4dannjjm 6726 28 of of IN cord-023095-4dannjjm 6726 29 this this DT cord-023095-4dannjjm 6726 30 study study NN cord-023095-4dannjjm 6726 31 indicate indicate VBP cord-023095-4dannjjm 6726 32 that that IN cord-023095-4dannjjm 6726 33 HSS HSS NNP cord-023095-4dannjjm 6726 34 may may MD cord-023095-4dannjjm 6726 35 provide provide VB cord-023095-4dannjjm 6726 36 faster fast JJR cord-023095-4dannjjm 6726 37 restoration restoration NN cord-023095-4dannjjm 6726 38 of of IN cord-023095-4dannjjm 6726 39 intravascular intravascular JJ cord-023095-4dannjjm 6726 40 volume volume NN cord-023095-4dannjjm 6726 41 deficits deficit NNS cord-023095-4dannjjm 6726 42 than than IN cord-023095-4dannjjm 6726 43 ISS ISS NNP cord-023095-4dannjjm 6726 44 in in IN cord-023095-4dannjjm 6726 45 endurance endurance NN cord-023095-4dannjjm 6726 46 horses horse NNS cord-023095-4dannjjm 6726 47 receiving receive VBG cord-023095-4dannjjm 6726 48 emergency emergency NN cord-023095-4dannjjm 6726 49 medical medical JJ cord-023095-4dannjjm 6726 50 treatment treatment NN cord-023095-4dannjjm 6726 51 . . . cord-023095-4dannjjm 6727 1 More more RBR cord-023095-4dannjjm 6727 2 profound profound JJ cord-023095-4dannjjm 6727 3 electrolyte electrolyte JJ cord-023095-4dannjjm 6727 4 changes change NNS cord-023095-4dannjjm 6727 5 should should MD cord-023095-4dannjjm 6727 6 be be VB cord-023095-4dannjjm 6727 7 expected expect VBN cord-023095-4dannjjm 6727 8 with with IN cord-023095-4dannjjm 6727 9 HSS HSS NNP cord-023095-4dannjjm 6727 10 however however RB cord-023095-4dannjjm 6727 11 . . . cord-023095-4dannjjm 6728 1 b b LS cord-023095-4dannjjm 6728 2 2 2 CD cord-023095-4dannjjm 6729 1 -adrenergic -adrenergic JJ cord-023095-4dannjjm 6729 2 receptor receptor NN cord-023095-4dannjjm 6729 3 agonists agonist NNS cord-023095-4dannjjm 6729 4 have have VBP cord-023095-4dannjjm 6729 5 been be VBN cord-023095-4dannjjm 6729 6 shown show VBN cord-023095-4dannjjm 6729 7 to to TO cord-023095-4dannjjm 6729 8 increase increase VB cord-023095-4dannjjm 6729 9 erythrocyte erythrocyte NN cord-023095-4dannjjm 6729 10 carbonic carbonic JJ cord-023095-4dannjjm 6729 11 anhydrase anhydrase NN cord-023095-4dannjjm 6729 12 activity activity NN cord-023095-4dannjjm 6729 13 , , , cord-023095-4dannjjm 6729 14 which which WDT cord-023095-4dannjjm 6729 15 may may MD cord-023095-4dannjjm 6729 16 stimulate stimulate VB cord-023095-4dannjjm 6729 17 the the DT cord-023095-4dannjjm 6729 18 Jacobs Jacobs NNP cord-023095-4dannjjm 6729 19 - - HYPH cord-023095-4dannjjm 6729 20 Stewart Stewart NNP cord-023095-4dannjjm 6729 21 cycle cycle NN cord-023095-4dannjjm 6729 22 and and CC cord-023095-4dannjjm 6729 23 increase increase VB cord-023095-4dannjjm 6729 24 pulmonary pulmonary JJ cord-023095-4dannjjm 6729 25 circulation circulation NN cord-023095-4dannjjm 6729 26 transvascular transvascular NNP cord-023095-4dannjjm 6729 27 fluid fluid JJ cord-023095-4dannjjm 6729 28 fluxes flux NNS cord-023095-4dannjjm 6729 29 during during IN cord-023095-4dannjjm 6729 30 exercise exercise NN cord-023095-4dannjjm 6729 31 . . . cord-023095-4dannjjm 6730 1 Increase increase VB cord-023095-4dannjjm 6730 2 in in IN cord-023095-4dannjjm 6730 3 pulmonary pulmonary JJ cord-023095-4dannjjm 6730 4 transvascular transvascular JJ cord-023095-4dannjjm 6730 5 fluid fluid JJ cord-023095-4dannjjm 6730 6 fluxes flux NNS cord-023095-4dannjjm 6730 7 ( ( -LRB- cord-023095-4dannjjm 6730 8 J J NNP cord-023095-4dannjjm 6730 9 V V NNP cord-023095-4dannjjm 6730 10 - - HYPH cord-023095-4dannjjm 6730 11 A A NNP cord-023095-4dannjjm 6730 12 ) ) -RRB- cord-023095-4dannjjm 6730 13 and and CC cord-023095-4dannjjm 6730 14 consequent consequent JJ cord-023095-4dannjjm 6730 15 increase increase NN cord-023095-4dannjjm 6730 16 in in IN cord-023095-4dannjjm 6730 17 the the DT cord-023095-4dannjjm 6730 18 pulmonary pulmonary JJ cord-023095-4dannjjm 6730 19 interstitial interstitial JJ cord-023095-4dannjjm 6730 20 fluid fluid NN cord-023095-4dannjjm 6730 21 would would MD cord-023095-4dannjjm 6730 22 be be VB cord-023095-4dannjjm 6730 23 detrimental detrimental JJ cord-023095-4dannjjm 6730 24 for for IN cord-023095-4dannjjm 6730 25 alveolar alveolar NN cord-023095-4dannjjm 6730 26 O o NN cord-023095-4dannjjm 6730 27 2 2 CD cord-023095-4dannjjm 6730 28 exchange exchange NN cord-023095-4dannjjm 6730 29 during during IN cord-023095-4dannjjm 6730 30 the the DT cord-023095-4dannjjm 6730 31 fast fast JJ cord-023095-4dannjjm 6730 32 erythrocyte erythrocyte NN cord-023095-4dannjjm 6730 33 transition transition NN cord-023095-4dannjjm 6730 34 time time NN cord-023095-4dannjjm 6730 35 across across IN cord-023095-4dannjjm 6730 36 the the DT cord-023095-4dannjjm 6730 37 pulmonary pulmonary JJ cord-023095-4dannjjm 6730 38 capillaries capillary NNS cord-023095-4dannjjm 6730 39 . . . cord-023095-4dannjjm 6731 1 Therefore therefore RB cord-023095-4dannjjm 6731 2 , , , cord-023095-4dannjjm 6731 3 we -PRON- PRP cord-023095-4dannjjm 6731 4 hypothesised hypothesise VBD cord-023095-4dannjjm 6731 5 that that DT cord-023095-4dannjjm 6731 6 treatment treatment NN cord-023095-4dannjjm 6731 7 with with IN cord-023095-4dannjjm 6731 8 inhaled inhale VBN cord-023095-4dannjjm 6731 9 b b NN cord-023095-4dannjjm 6731 10 2 2 CD cord-023095-4dannjjm 6731 11 -adrenergic -adrenergic JJ cord-023095-4dannjjm 6731 12 receptor receptor NN cord-023095-4dannjjm 6731 13 agonist agonist NN cord-023095-4dannjjm 6731 14 will will MD cord-023095-4dannjjm 6731 15 increase increase VB cord-023095-4dannjjm 6731 16 J J NNP cord-023095-4dannjjm 6731 17 V V NNP cord-023095-4dannjjm 6731 18 - - HYPH cord-023095-4dannjjm 6731 19 A A NNP cord-023095-4dannjjm 6731 20 and and CC cord-023095-4dannjjm 6731 21 the the DT cord-023095-4dannjjm 6731 22 alveolar alveolar NN cord-023095-4dannjjm 6731 23 - - HYPH cord-023095-4dannjjm 6731 24 arterial arterial JJ cord-023095-4dannjjm 6731 25 PO po NN cord-023095-4dannjjm 6731 26 2 2 CD cord-023095-4dannjjm 6731 27 difference difference NN cord-023095-4dannjjm 6731 28 ( ( -LRB- cord-023095-4dannjjm 6731 29 AaDO AaDO NNP cord-023095-4dannjjm 6731 30 2 2 CD cord-023095-4dannjjm 6731 31 ) ) -RRB- cord-023095-4dannjjm 6731 32 during during IN cord-023095-4dannjjm 6731 33 exercise exercise NN cord-023095-4dannjjm 6731 34 . . . cord-023095-4dannjjm 6732 1 Six six CD cord-023095-4dannjjm 6732 2 STB STB NNP cord-023095-4dannjjm 6732 3 horses horse NNS cord-023095-4dannjjm 6732 4 were be VBD cord-023095-4dannjjm 6732 5 exercised exercise VBN cord-023095-4dannjjm 6732 6 on on IN cord-023095-4dannjjm 6732 7 a a DT cord-023095-4dannjjm 6732 8 high high JJ cord-023095-4dannjjm 6732 9 - - HYPH cord-023095-4dannjjm 6732 10 speed speed NN cord-023095-4dannjjm 6732 11 treadmill treadmill NN cord-023095-4dannjjm 6732 12 at at IN cord-023095-4dannjjm 6732 13 80 80 CD cord-023095-4dannjjm 6732 14 % % NN cord-023095-4dannjjm 6732 15 VO VO NNP cord-023095-4dannjjm 6732 16 2 2 CD cord-023095-4dannjjm 6732 17 peak peak NN cord-023095-4dannjjm 6732 18 until until IN cord-023095-4dannjjm 6732 19 fatigue fatigue NN cord-023095-4dannjjm 6732 20 . . . cord-023095-4dannjjm 6733 1 Horses horse NNS cord-023095-4dannjjm 6733 2 were be VBD cord-023095-4dannjjm 6733 3 randomly randomly RB cord-023095-4dannjjm 6733 4 assigned assign VBN cord-023095-4dannjjm 6733 5 to to IN cord-023095-4dannjjm 6733 6 treatment treatment NN cord-023095-4dannjjm 6733 7 with with IN cord-023095-4dannjjm 6733 8 salbutamol salbutamol NN cord-023095-4dannjjm 6733 9 ( ( -LRB- cord-023095-4dannjjm 6733 10 Sal Sal NNP cord-023095-4dannjjm 6733 11 : : : cord-023095-4dannjjm 6733 12 500mcg 500mcg CD cord-023095-4dannjjm 6733 13 ) ) -RRB- cord-023095-4dannjjm 6733 14 or or CC cord-023095-4dannjjm 6733 15 placebo placebo NN cord-023095-4dannjjm 6733 16 ( ( -LRB- cord-023095-4dannjjm 6733 17 Control control NN cord-023095-4dannjjm 6733 18 : : : cord-023095-4dannjjm 6734 1 Con con NN cord-023095-4dannjjm 6734 2 ) ) -RRB- cord-023095-4dannjjm 6734 3 inhalation inhalation NN cord-023095-4dannjjm 6734 4 via via IN cord-023095-4dannjjm 6734 5 Aeromask Aeromask NNP cord-023095-4dannjjm 6734 6 Ã Ã NNP cord-023095-4dannjjm 6734 7 60 60 CD cord-023095-4dannjjm 6734 8 min min NN cord-023095-4dannjjm 6734 9 prior prior RB cord-023095-4dannjjm 6734 10 to to IN cord-023095-4dannjjm 6734 11 exercise exercise VB cord-023095-4dannjjm 6734 12 , , , cord-023095-4dannjjm 6734 13 with with IN cord-023095-4dannjjm 6734 14 cross cross NN cord-023095-4dannjjm 6734 15 over over IN cord-023095-4dannjjm 6734 16 treatment treatment NN cord-023095-4dannjjm 6734 17 used use VBN cord-023095-4dannjjm 6734 18 at at IN cord-023095-4dannjjm 6734 19 the the DT cord-023095-4dannjjm 6734 20 repeated repeat VBN cord-023095-4dannjjm 6734 21 exercise exercise NN cord-023095-4dannjjm 6734 22 test test NN cord-023095-4dannjjm 6734 23 ( ( -LRB- cord-023095-4dannjjm 6734 24 8 8 CD cord-023095-4dannjjm 6734 25 days day NNS cord-023095-4dannjjm 6734 26 later later RB cord-023095-4dannjjm 6734 27 ) ) -RRB- cord-023095-4dannjjm 6734 28 . . . cord-023095-4dannjjm 6735 1 Arterial arterial JJ cord-023095-4dannjjm 6735 2 and and CC cord-023095-4dannjjm 6735 3 mixedvenous mixedvenous JJ cord-023095-4dannjjm 6735 4 blood blood NN cord-023095-4dannjjm 6735 5 , , , cord-023095-4dannjjm 6735 6 as as RB cord-023095-4dannjjm 6735 7 well well RB cord-023095-4dannjjm 6735 8 as as IN cord-023095-4dannjjm 6735 9 CO co NN cord-023095-4dannjjm 6735 10 2 2 CD cord-023095-4dannjjm 6735 11 elimination elimination NN cord-023095-4dannjjm 6735 12 and and CC cord-023095-4dannjjm 6735 13 O o NN cord-023095-4dannjjm 6735 14 2 2 CD cord-023095-4dannjjm 6735 15 uptake uptake NN cord-023095-4dannjjm 6735 16 , , , cord-023095-4dannjjm 6735 17 were be VBD cord-023095-4dannjjm 6735 18 sampled sample VBN cord-023095-4dannjjm 6735 19 simultaneously simultaneously RB cord-023095-4dannjjm 6735 20 at at IN cord-023095-4dannjjm 6735 21 rest rest NN cord-023095-4dannjjm 6735 22 , , , cord-023095-4dannjjm 6735 23 during during IN cord-023095-4dannjjm 6735 24 exercise exercise NN cord-023095-4dannjjm 6735 25 at at IN cord-023095-4dannjjm 6735 26 60 60 CD cord-023095-4dannjjm 6735 27 sec sec NNP cord-023095-4dannjjm 6735 28 intervals interval NNS cord-023095-4dannjjm 6735 29 until until IN cord-023095-4dannjjm 6735 30 fatigue fatigue NN cord-023095-4dannjjm 6735 31 , , , cord-023095-4dannjjm 6735 32 and and CC cord-023095-4dannjjm 6735 33 into into IN cord-023095-4dannjjm 6735 34 recovery recovery NN cord-023095-4dannjjm 6735 35 . . . cord-023095-4dannjjm 6736 1 Blood blood NN cord-023095-4dannjjm 6736 2 gases gas NNS cord-023095-4dannjjm 6736 3 were be VBD cord-023095-4dannjjm 6736 4 analyzed analyze VBN cord-023095-4dannjjm 6736 5 . . . cord-023095-4dannjjm 6737 1 AaDO AaDO NNP cord-023095-4dannjjm 6737 2 2 2 CD cord-023095-4dannjjm 6737 3 was be VBD cord-023095-4dannjjm 6737 4 calculated calculate VBN cord-023095-4dannjjm 6737 5 using use VBG cord-023095-4dannjjm 6737 6 the the DT cord-023095-4dannjjm 6737 7 inspired inspire VBN cord-023095-4dannjjm 6737 8 PO PO NNP cord-023095-4dannjjm 6737 9 2 2 CD cord-023095-4dannjjm 6737 10 ( ( -LRB- cord-023095-4dannjjm 6737 11 149 149 CD cord-023095-4dannjjm 6737 12 mmHg mmHg NNS cord-023095-4dannjjm 6737 13 ) ) -RRB- cord-023095-4dannjjm 6737 14 , , , cord-023095-4dannjjm 6737 15 and and CC cord-023095-4dannjjm 6737 16 blood blood NN cord-023095-4dannjjm 6737 17 partial partial JJ cord-023095-4dannjjm 6737 18 pressure pressure NN cord-023095-4dannjjm 6737 19 of of IN cord-023095-4dannjjm 6737 20 O o NN cord-023095-4dannjjm 6737 21 2 2 CD cord-023095-4dannjjm 6737 22 and and CC cord-023095-4dannjjm 6737 23 CO CO NNP cord-023095-4dannjjm 6737 24 2 2 CD cord-023095-4dannjjm 6737 25 . . . cord-023095-4dannjjm 6738 1 Blood blood NN cord-023095-4dannjjm 6738 2 volume volume NN cord-023095-4dannjjm 6738 3 ( ( -LRB- cord-023095-4dannjjm 6738 4 % % NN cord-023095-4dannjjm 6738 5 ) ) -RRB- cord-023095-4dannjjm 6738 6 changes change NNS cord-023095-4dannjjm 6738 7 across across IN cord-023095-4dannjjm 6738 8 the the DT cord-023095-4dannjjm 6738 9 lung lung NN cord-023095-4dannjjm 6738 10 were be VBD cord-023095-4dannjjm 6738 11 calculated calculate VBN cord-023095-4dannjjm 6738 12 from from IN cord-023095-4dannjjm 6738 13 changes change NNS cord-023095-4dannjjm 6738 14 in in IN cord-023095-4dannjjm 6738 15 hemoglobin hemoglobin NN cord-023095-4dannjjm 6738 16 and and CC cord-023095-4dannjjm 6738 17 hematocrit hematocrit NN cord-023095-4dannjjm 6738 18 values value NNS cord-023095-4dannjjm 6738 19 in in IN cord-023095-4dannjjm 6738 20 venous venous JJ cord-023095-4dannjjm 6738 21 and and CC cord-023095-4dannjjm 6738 22 arterial arterial JJ cord-023095-4dannjjm 6738 23 blood blood NN cord-023095-4dannjjm 6738 24 . . . cord-023095-4dannjjm 6739 1 Cardiac cardiac JJ cord-023095-4dannjjm 6739 2 output output NN cord-023095-4dannjjm 6739 3 ( ( -LRB- cord-023095-4dannjjm 6739 4 Q Q NNP cord-023095-4dannjjm 6739 5 ) ) -RRB- cord-023095-4dannjjm 6739 6 was be VBD cord-023095-4dannjjm 6739 7 calculated calculate VBN cord-023095-4dannjjm 6739 8 using use VBG cord-023095-4dannjjm 6739 9 the the DT cord-023095-4dannjjm 6739 10 Fick Fick NNP cord-023095-4dannjjm 6739 11 equation equation NN cord-023095-4dannjjm 6739 12 . . . cord-023095-4dannjjm 6740 1 J J NNP cord-023095-4dannjjm 6740 2 V V NNP cord-023095-4dannjjm 6740 3 - - : cord-023095-4dannjjm 6740 4 A A NNP cord-023095-4dannjjm 6740 5 was be VBD cord-023095-4dannjjm 6740 6 calculated calculate VBN cord-023095-4dannjjm 6740 7 using use VBG cord-023095-4dannjjm 6740 8 Q q NN cord-023095-4dannjjm 6740 9 and and CC cord-023095-4dannjjm 6740 10 blood blood NN cord-023095-4dannjjm 6740 11 volume volume NN cord-023095-4dannjjm 6740 12 changes change NNS cord-023095-4dannjjm 6740 13 across across IN cord-023095-4dannjjm 6740 14 the the DT cord-023095-4dannjjm 6740 15 lung lung NN cord-023095-4dannjjm 6740 16 . . . cord-023095-4dannjjm 6741 1 Variables variable NNS cord-023095-4dannjjm 6741 2 were be VBD cord-023095-4dannjjm 6741 3 analyzed analyze VBN cord-023095-4dannjjm 6741 4 using use VBG cord-023095-4dannjjm 6741 5 two two CD cord-023095-4dannjjm 6741 6 - - HYPH cord-023095-4dannjjm 6741 7 way way NN cord-023095-4dannjjm 6741 8 repeated repeat VBN cord-023095-4dannjjm 6741 9 - - HYPH cord-023095-4dannjjm 6741 10 measures measure NNS cord-023095-4dannjjm 6741 11 ANOVA ANOVA NNP cord-023095-4dannjjm 6741 12 ( ( -LRB- cord-023095-4dannjjm 6741 13 P p NN cord-023095-4dannjjm 6741 14 o o NN cord-023095-4dannjjm 6741 15 0.05).The 0.05).the CD cord-023095-4dannjjm 6741 16 duration duration NN cord-023095-4dannjjm 6741 17 of of IN cord-023095-4dannjjm 6741 18 exercise exercise NN cord-023095-4dannjjm 6741 19 to to IN cord-023095-4dannjjm 6741 20 fatigue fatigue NN cord-023095-4dannjjm 6741 21 was be VBD cord-023095-4dannjjm 6741 22 4.3 4.3 CD cord-023095-4dannjjm 6741 23 AE AE NNP cord-023095-4dannjjm 6741 24 0.3 0.3 CD cord-023095-4dannjjm 6741 25 min min NN cord-023095-4dannjjm 6741 26 and and CC cord-023095-4dannjjm 6741 27 4.4 4.4 CD cord-023095-4dannjjm 6741 28 AE AE NNP cord-023095-4dannjjm 6741 29 0.4 0.4 CD cord-023095-4dannjjm 6741 30 min min NN cord-023095-4dannjjm 6741 31 in in IN cord-023095-4dannjjm 6741 32 both both CC cord-023095-4dannjjm 6741 33 Con Con NNP cord-023095-4dannjjm 6741 34 and and CC cord-023095-4dannjjm 6741 35 Sal Sal NNP cord-023095-4dannjjm 6741 36 , , , cord-023095-4dannjjm 6741 37 respectively respectively RB cord-023095-4dannjjm 6741 38 . . . cord-023095-4dannjjm 6742 1 At at IN cord-023095-4dannjjm 6742 2 rest rest NN cord-023095-4dannjjm 6742 3 Sal Sal NNP cord-023095-4dannjjm 6742 4 had have VBD cord-023095-4dannjjm 6742 5 no no DT cord-023095-4dannjjm 6742 6 effect effect NN cord-023095-4dannjjm 6742 7 on on IN cord-023095-4dannjjm 6742 8 J J NNP cord-023095-4dannjjm 6742 9 V V NNP cord-023095-4dannjjm 6742 10 - - HYPH cord-023095-4dannjjm 6742 11 A A NNP cord-023095-4dannjjm 6742 12 , , , cord-023095-4dannjjm 6742 13 oxygen oxygen NN cord-023095-4dannjjm 6742 14 consumption consumption NN cord-023095-4dannjjm 6742 15 ( ( -LRB- cord-023095-4dannjjm 6742 16 VO VO NNP cord-023095-4dannjjm 6742 17 2 2 CD cord-023095-4dannjjm 6742 18 ) ) -RRB- cord-023095-4dannjjm 6742 19 , , , cord-023095-4dannjjm 6742 20 blood blood NN cord-023095-4dannjjm 6742 21 oxygen oxygen NN cord-023095-4dannjjm 6742 22 saturation saturation NN cord-023095-4dannjjm 6742 23 ( ( -LRB- cord-023095-4dannjjm 6742 24 SO so RB cord-023095-4dannjjm 6742 25 2 2 CD cord-023095-4dannjjm 6742 26 ) ) -RRB- cord-023095-4dannjjm 6742 27 or or CC cord-023095-4dannjjm 6742 28 AaDO AaDO NNP cord-023095-4dannjjm 6742 29 2 2 CD cord-023095-4dannjjm 6742 30 ( ( -LRB- cord-023095-4dannjjm 6742 31 P40.05 p40.05 NN cord-023095-4dannjjm 6742 32 ) ) -RRB- cord-023095-4dannjjm 6742 33 . . . cord-023095-4dannjjm 6743 1 At at IN cord-023095-4dannjjm 6743 2 the the DT cord-023095-4dannjjm 6743 3 onset onset NN cord-023095-4dannjjm 6743 4 of of IN cord-023095-4dannjjm 6743 5 exercise exercise NN cord-023095-4dannjjm 6743 6 J J NNP cord-023095-4dannjjm 6743 7 V V NNP cord-023095-4dannjjm 6743 8 - - : cord-023095-4dannjjm 6743 9 A A NNP cord-023095-4dannjjm 6743 10 increased increase VBN cord-023095-4dannjjm 6743 11 in in IN cord-023095-4dannjjm 6743 12 Con Con NNP cord-023095-4dannjjm 6743 13 and and CC cord-023095-4dannjjm 6743 14 Sal Sal NNP cord-023095-4dannjjm 6743 15 ( ( -LRB- cord-023095-4dannjjm 6743 16 P p NN cord-023095-4dannjjm 6743 17 o o CD cord-023095-4dannjjm 6743 18 0.0001 0.0001 CD cord-023095-4dannjjm 6743 19 ) ) -RRB- cord-023095-4dannjjm 6743 20 and and CC cord-023095-4dannjjm 6743 21 at at IN cord-023095-4dannjjm 6743 22 fatigue fatigue NN cord-023095-4dannjjm 6743 23 reached reach VBD cord-023095-4dannjjm 6743 24 10.0 10.0 CD cord-023095-4dannjjm 6743 25 AE AE NNP cord-023095-4dannjjm 6743 26 2.4 2.4 CD cord-023095-4dannjjm 6743 27 L l NN cord-023095-4dannjjm 6743 28 / / SYM cord-023095-4dannjjm 6743 29 min min NN cord-023095-4dannjjm 6743 30 and and CC cord-023095-4dannjjm 6743 31 10.0 10.0 CD cord-023095-4dannjjm 6743 32 AE AE NNP cord-023095-4dannjjm 6743 33 1.6 1.6 CD cord-023095-4dannjjm 6743 34 L l NN cord-023095-4dannjjm 6743 35 / / SYM cord-023095-4dannjjm 6743 36 min min NN cord-023095-4dannjjm 6743 37 , , , cord-023095-4dannjjm 6743 38 respectively respectively RB cord-023095-4dannjjm 6743 39 . . . cord-023095-4dannjjm 6744 1 Treatment treatment NN cord-023095-4dannjjm 6744 2 with with IN cord-023095-4dannjjm 6744 3 Sal Sal NNP cord-023095-4dannjjm 6744 4 had have VBD cord-023095-4dannjjm 6744 5 no no DT cord-023095-4dannjjm 6744 6 effect effect NN cord-023095-4dannjjm 6744 7 on on IN cord-023095-4dannjjm 6744 8 J J NNP cord-023095-4dannjjm 6744 9 V V NNP cord-023095-4dannjjm 6744 10 - - : cord-023095-4dannjjm 6744 11 A a NN cord-023095-4dannjjm 6744 12 during during IN cord-023095-4dannjjm 6744 13 exercise exercise NN cord-023095-4dannjjm 6744 14 ( ( -LRB- cord-023095-4dannjjm 6744 15 P p NN cord-023095-4dannjjm 6744 16 5 5 CD cord-023095-4dannjjm 6744 17 0.9 0.9 CD cord-023095-4dannjjm 6744 18 ) ) -RRB- cord-023095-4dannjjm 6744 19 . . . cord-023095-4dannjjm 6745 1 At at IN cord-023095-4dannjjm 6745 2 the the DT cord-023095-4dannjjm 6745 3 onset onset NN cord-023095-4dannjjm 6745 4 of of IN cord-023095-4dannjjm 6745 5 exercise exercise NN cord-023095-4dannjjm 6745 6 SO so RB cord-023095-4dannjjm 6745 7 2 2 CD cord-023095-4dannjjm 6745 8 and and CC cord-023095-4dannjjm 6745 9 VO VO NNP cord-023095-4dannjjm 6745 10 2 2 CD cord-023095-4dannjjm 6745 11 increased increase VBD cord-023095-4dannjjm 6745 12 in in IN cord-023095-4dannjjm 6745 13 Con Con NNP cord-023095-4dannjjm 6745 14 and and CC cord-023095-4dannjjm 6745 15 Sal Sal NNP cord-023095-4dannjjm 6745 16 ( ( -LRB- cord-023095-4dannjjm 6745 17 P p NN cord-023095-4dannjjm 6745 18 o o NN cord-023095-4dannjjm 6745 19 0.0001 0.0001 CD cord-023095-4dannjjm 6745 20 ) ) -RRB- cord-023095-4dannjjm 6745 21 . . . cord-023095-4dannjjm 6746 1 Treatment treatment NN cord-023095-4dannjjm 6746 2 with with IN cord-023095-4dannjjm 6746 3 Sal Sal NNP cord-023095-4dannjjm 6746 4 had have VBD cord-023095-4dannjjm 6746 5 no no DT cord-023095-4dannjjm 6746 6 effect effect NN cord-023095-4dannjjm 6746 7 on on IN cord-023095-4dannjjm 6746 8 SO so RB cord-023095-4dannjjm 6746 9 2 2 CD cord-023095-4dannjjm 6746 10 or or CC cord-023095-4dannjjm 6746 11 VO VO NNP cord-023095-4dannjjm 6746 12 2 2 CD cord-023095-4dannjjm 6746 13 during during IN cord-023095-4dannjjm 6746 14 exercise exercise NN cord-023095-4dannjjm 6746 15 ( ( -LRB- cord-023095-4dannjjm 6746 16 P40.05 p40.05 NN cord-023095-4dannjjm 6746 17 ) ) -RRB- cord-023095-4dannjjm 6746 18 . . . cord-023095-4dannjjm 6747 1 AaDO AaDO NNP cord-023095-4dannjjm 6747 2 2 2 CD cord-023095-4dannjjm 6747 3 increased increase VBD cord-023095-4dannjjm 6747 4 during during IN cord-023095-4dannjjm 6747 5 exercise exercise NN cord-023095-4dannjjm 6747 6 in in IN cord-023095-4dannjjm 6747 7 Con Con NNP cord-023095-4dannjjm 6747 8 and and CC cord-023095-4dannjjm 6747 9 Sal Sal NNP cord-023095-4dannjjm 6747 10 ( ( -LRB- cord-023095-4dannjjm 6747 11 P p NN cord-023095-4dannjjm 6747 12 o o CD cord-023095-4dannjjm 6747 13 0.0001 0.0001 CD cord-023095-4dannjjm 6747 14 ) ) -RRB- cord-023095-4dannjjm 6747 15 and and CC cord-023095-4dannjjm 6747 16 at at IN cord-023095-4dannjjm 6747 17 fatigue fatigue NN cord-023095-4dannjjm 6747 18 reached reach VBD cord-023095-4dannjjm 6747 19 19.4 19.4 CD cord-023095-4dannjjm 6747 20 AE AE NNP cord-023095-4dannjjm 6747 21 2.3 2.3 CD cord-023095-4dannjjm 6747 22 mmHg mmHg NNS cord-023095-4dannjjm 6747 23 and and CC cord-023095-4dannjjm 6747 24 18.1 18.1 CD cord-023095-4dannjjm 6747 25 AE AE NNP cord-023095-4dannjjm 6747 26 2.4 2.4 CD cord-023095-4dannjjm 6747 27 mmHg mmHg NNS cord-023095-4dannjjm 6747 28 , , , cord-023095-4dannjjm 6747 29 respectively respectively RB cord-023095-4dannjjm 6747 30 . . . cord-023095-4dannjjm 6748 1 Treatment treatment NN cord-023095-4dannjjm 6748 2 with with IN cord-023095-4dannjjm 6748 3 Sal Sal NNP cord-023095-4dannjjm 6748 4 had have VBD cord-023095-4dannjjm 6748 5 no no DT cord-023095-4dannjjm 6748 6 effect effect NN cord-023095-4dannjjm 6748 7 on on IN cord-023095-4dannjjm 6748 8 AaDO AaDO NNP cord-023095-4dannjjm 6748 9 2 2 CD cord-023095-4dannjjm 6748 10 during during IN cord-023095-4dannjjm 6748 11 exercise exercise NN cord-023095-4dannjjm 6749 1 ( ( -LRB- cord-023095-4dannjjm 6749 2 P p NN cord-023095-4dannjjm 6749 3 5 5 CD cord-023095-4dannjjm 6749 4 0.3).Inhaled 0.3).inhaled CD cord-023095-4dannjjm 6749 5 b b NN cord-023095-4dannjjm 6749 6 2 2 CD cord-023095-4dannjjm 6749 7 -adrenergic -adrenergic JJ cord-023095-4dannjjm 6749 8 receptor receptor NN cord-023095-4dannjjm 6749 9 agonist agonist NN cord-023095-4dannjjm 6749 10 salbutamol salbutamol NN cord-023095-4dannjjm 6749 11 at at IN cord-023095-4dannjjm 6749 12 the the DT cord-023095-4dannjjm 6749 13 dose dose NN cord-023095-4dannjjm 6749 14 of of IN cord-023095-4dannjjm 6749 15 500mcg 500mcg NNP cord-023095-4dannjjm 6749 16 given give VBN cord-023095-4dannjjm 6749 17 60 60 CD cord-023095-4dannjjm 6749 18 min min NN cord-023095-4dannjjm 6749 19 before before IN cord-023095-4dannjjm 6749 20 exercise exercise NN cord-023095-4dannjjm 6749 21 did do VBD cord-023095-4dannjjm 6749 22 not not RB cord-023095-4dannjjm 6749 23 affect affect VB cord-023095-4dannjjm 6749 24 the the DT cord-023095-4dannjjm 6749 25 duration duration NN cord-023095-4dannjjm 6749 26 of of IN cord-023095-4dannjjm 6749 27 exercise exercise NN cord-023095-4dannjjm 6749 28 to to IN cord-023095-4dannjjm 6749 29 fatigue fatigue NN cord-023095-4dannjjm 6749 30 , , , cord-023095-4dannjjm 6749 31 J J NNP cord-023095-4dannjjm 6749 32 V V NNP cord-023095-4dannjjm 6749 33 - - HYPH cord-023095-4dannjjm 6749 34 A A NNP cord-023095-4dannjjm 6749 35 , , , cord-023095-4dannjjm 6749 36 VO VO NNP cord-023095-4dannjjm 6749 37 2 2 CD cord-023095-4dannjjm 6749 38 , , , cord-023095-4dannjjm 6749 39 SO so RB cord-023095-4dannjjm 6749 40 2 2 CD cord-023095-4dannjjm 6749 41 or or CC cord-023095-4dannjjm 6749 42 AaDO AaDO NNP cord-023095-4dannjjm 6749 43 2 2 CD cord-023095-4dannjjm 6749 44 . . . cord-023095-4dannjjm 6750 1 Therefore therefore RB cord-023095-4dannjjm 6750 2 , , , cord-023095-4dannjjm 6750 3 it -PRON- PRP cord-023095-4dannjjm 6750 4 had have VBD cord-023095-4dannjjm 6750 5 no no DT cord-023095-4dannjjm 6750 6 detrimental detrimental JJ cord-023095-4dannjjm 6750 7 effect effect NN cord-023095-4dannjjm 6750 8 on on IN cord-023095-4dannjjm 6750 9 alveolar alveolar NN cord-023095-4dannjjm 6750 10 - - HYPH cord-023095-4dannjjm 6750 11 capillary capillary JJ cord-023095-4dannjjm 6750 12 diffusion diffusion NN cord-023095-4dannjjm 6750 13 distance distance NN cord-023095-4dannjjm 6750 14 and and CC cord-023095-4dannjjm 6750 15 the the DT cord-023095-4dannjjm 6750 16 ventilation ventilation NN cord-023095-4dannjjm 6750 17 / / SYM cord-023095-4dannjjm 6750 18 perfusion perfusion NN cord-023095-4dannjjm 6750 19 mismatch mismatch NN cord-023095-4dannjjm 6750 20 in in IN cord-023095-4dannjjm 6750 21 exercising exercise VBG cord-023095-4dannjjm 6750 22 horses horse NNS cord-023095-4dannjjm 6750 23 . . . cord-023095-4dannjjm 6751 1 Inflammatory inflammatory JJ cord-023095-4dannjjm 6751 2 Airway Airway NNP cord-023095-4dannjjm 6751 3 Disease Disease NNP cord-023095-4dannjjm 6751 4 ( ( -LRB- cord-023095-4dannjjm 6751 5 IAD IAD NNP cord-023095-4dannjjm 6751 6 ) ) -RRB- cord-023095-4dannjjm 6751 7 and and CC cord-023095-4dannjjm 6751 8 recurrent recurrent JJ cord-023095-4dannjjm 6751 9 airway airway JJ cord-023095-4dannjjm 6751 10 obstruction obstruction NN cord-023095-4dannjjm 6751 11 ( ( -LRB- cord-023095-4dannjjm 6751 12 RAO RAO NNP cord-023095-4dannjjm 6751 13 ) ) -RRB- cord-023095-4dannjjm 6751 14 represent represent VBP cord-023095-4dannjjm 6751 15 two two CD cord-023095-4dannjjm 6751 16 classes class NNS cord-023095-4dannjjm 6751 17 of of IN cord-023095-4dannjjm 6751 18 equine equine JJ cord-023095-4dannjjm 6751 19 lung lung NN cord-023095-4dannjjm 6751 20 inflammatory inflammatory JJ cord-023095-4dannjjm 6751 21 diseases disease NNS cord-023095-4dannjjm 6751 22 that that WDT cord-023095-4dannjjm 6751 23 may may MD cord-023095-4dannjjm 6751 24 share share VB cord-023095-4dannjjm 6751 25 some some DT cord-023095-4dannjjm 6751 26 similar similar JJ cord-023095-4dannjjm 6751 27 immunologic immunologic JJ cord-023095-4dannjjm 6751 28 mechanisms mechanism NNS cord-023095-4dannjjm 6751 29 . . . cord-023095-4dannjjm 6752 1 There there EX cord-023095-4dannjjm 6752 2 is be VBZ cord-023095-4dannjjm 6752 3 evidence evidence NN cord-023095-4dannjjm 6752 4 that that IN cord-023095-4dannjjm 6752 5 Th2 Th2 NNP cord-023095-4dannjjm 6752 6 cytokines cytokine NNS cord-023095-4dannjjm 6752 7 and and CC cord-023095-4dannjjm 6752 8 IL-17 IL-17 NNP cord-023095-4dannjjm 6752 9 play play VB cord-023095-4dannjjm 6752 10 some some DT cord-023095-4dannjjm 6752 11 role role NN cord-023095-4dannjjm 6752 12 in in IN cord-023095-4dannjjm 6752 13 RAO RAO NNP cord-023095-4dannjjm 6752 14 . . . cord-023095-4dannjjm 6753 1 IAD IAD NNP cord-023095-4dannjjm 6753 2 is be VBZ cord-023095-4dannjjm 6753 3 a a DT cord-023095-4dannjjm 6753 4 common common JJ cord-023095-4dannjjm 6753 5 condition condition NN cord-023095-4dannjjm 6753 6 in in IN cord-023095-4dannjjm 6753 7 horses horse NNS cord-023095-4dannjjm 6753 8 , , , cord-023095-4dannjjm 6753 9 but but CC cord-023095-4dannjjm 6753 10 its -PRON- PRP$ cord-023095-4dannjjm 6753 11 pathophysiology pathophysiology NN cord-023095-4dannjjm 6753 12 is be VBZ cord-023095-4dannjjm 6753 13 still still RB cord-023095-4dannjjm 6753 14 not not RB cord-023095-4dannjjm 6753 15 understood understand VBN cord-023095-4dannjjm 6753 16 . . . cord-023095-4dannjjm 6754 1 The the DT cord-023095-4dannjjm 6754 2 aim aim NN cord-023095-4dannjjm 6754 3 of of IN cord-023095-4dannjjm 6754 4 the the DT cord-023095-4dannjjm 6754 5 present present JJ cord-023095-4dannjjm 6754 6 study study NN cord-023095-4dannjjm 6754 7 was be VBD cord-023095-4dannjjm 6754 8 therefore therefore RB cord-023095-4dannjjm 6754 9 to to TO cord-023095-4dannjjm 6754 10 determine determine VB cord-023095-4dannjjm 6754 11 the the DT cord-023095-4dannjjm 6754 12 mRNA mRNA NNP cord-023095-4dannjjm 6754 13 expression expression NN cord-023095-4dannjjm 6754 14 of of IN cord-023095-4dannjjm 6754 15 Th1 th1 NN cord-023095-4dannjjm 6754 16 , , , cord-023095-4dannjjm 6754 17 Th2 Th2 NNP cord-023095-4dannjjm 6754 18 and and CC cord-023095-4dannjjm 6754 19 Th17 th17 CD cord-023095-4dannjjm 6754 20 inflammatory inflammatory JJ cord-023095-4dannjjm 6754 21 cytokines cytokine NNS cord-023095-4dannjjm 6754 22 , , , cord-023095-4dannjjm 6754 23 to to TO cord-023095-4dannjjm 6754 24 understand understand VB cord-023095-4dannjjm 6754 25 the the DT cord-023095-4dannjjm 6754 26 immunological immunological JJ cord-023095-4dannjjm 6754 27 mechanisms mechanism NNS cord-023095-4dannjjm 6754 28 of of IN cord-023095-4dannjjm 6754 29 IAD.The IAD.The NNP cord-023095-4dannjjm 6754 30 mRNA mRNA NNP cord-023095-4dannjjm 6754 31 expression expression NN cord-023095-4dannjjm 6754 32 of of IN cord-023095-4dannjjm 6754 33 ten ten CD cord-023095-4dannjjm 6754 34 inflammatory inflammatory JJ cord-023095-4dannjjm 6754 35 cytokines cytokine NNS cord-023095-4dannjjm 6754 36 and and CC cord-023095-4dannjjm 6754 37 chemokines chemokine NNS cord-023095-4dannjjm 6754 38 was be VBD cord-023095-4dannjjm 6754 39 measured measure VBN cord-023095-4dannjjm 6754 40 in in IN cord-023095-4dannjjm 6754 41 the the DT cord-023095-4dannjjm 6754 42 bronchoalveolar bronchoalveolar JJ cord-023095-4dannjjm 6754 43 fluid fluid NN cord-023095-4dannjjm 6754 44 ( ( -LRB- cord-023095-4dannjjm 6754 45 BALF BALF NNP cord-023095-4dannjjm 6754 46 ) ) -RRB- cord-023095-4dannjjm 6754 47 of of IN cord-023095-4dannjjm 6754 48 seventeen seventeen CD cord-023095-4dannjjm 6754 49 horses horse NNS cord-023095-4dannjjm 6754 50 with with IN cord-023095-4dannjjm 6754 51 IAD IAD NNP cord-023095-4dannjjm 6754 52 and and CC cord-023095-4dannjjm 6754 53 compared compare VBN cord-023095-4dannjjm 6754 54 with with IN cord-023095-4dannjjm 6754 55 ten ten CD cord-023095-4dannjjm 6754 56 control control NN cord-023095-4dannjjm 6754 57 horses horse NNS cord-023095-4dannjjm 6754 58 . . . cord-023095-4dannjjm 6755 1 The the DT cord-023095-4dannjjm 6755 2 horses horse NNS cord-023095-4dannjjm 6755 3 were be VBD cord-023095-4dannjjm 6755 4 selected select VBN cord-023095-4dannjjm 6755 5 based base VBN cord-023095-4dannjjm 6755 6 on on IN cord-023095-4dannjjm 6755 7 1-their 1-their CD cord-023095-4dannjjm 6755 8 clinical clinical JJ cord-023095-4dannjjm 6755 9 signs sign NNS cord-023095-4dannjjm 6755 10 , , , cord-023095-4dannjjm 6755 11 2-the 2-the NNP cord-023095-4dannjjm 6755 12 inflammatory inflammatory JJ cord-023095-4dannjjm 6755 13 cells cell NNS cord-023095-4dannjjm 6755 14 count count VBP cord-023095-4dannjjm 6755 15 in in IN cord-023095-4dannjjm 6755 16 the the DT cord-023095-4dannjjm 6755 17 BALF BALF NNP cord-023095-4dannjjm 6755 18 , , , cord-023095-4dannjjm 6755 19 3-their 3-their CD cord-023095-4dannjjm 6755 20 physical physical JJ cord-023095-4dannjjm 6755 21 examination examination NN cord-023095-4dannjjm 6755 22 and and CC cord-023095-4dannjjm 6755 23 4-their 4-their CD cord-023095-4dannjjm 6755 24 medical medical JJ cord-023095-4dannjjm 6755 25 history history NN cord-023095-4dannjjm 6755 26 . . . cord-023095-4dannjjm 6756 1 The the DT cord-023095-4dannjjm 6756 2 mRNA mrna NN cord-023095-4dannjjm 6756 3 expression expression NN cord-023095-4dannjjm 6756 4 of of IN cord-023095-4dannjjm 6756 5 IL-5 IL-5 NNP cord-023095-4dannjjm 6756 6 , , , cord-023095-4dannjjm 6756 7 IL-1b IL-1b NNP cord-023095-4dannjjm 6756 8 , , , cord-023095-4dannjjm 6756 9 IL-6 IL-6 NNP cord-023095-4dannjjm 6756 10 , , , cord-023095-4dannjjm 6756 11 IL-8 IL-8 NNP cord-023095-4dannjjm 6756 12 and and CC cord-023095-4dannjjm 6756 13 IL-10 IL-10 NNP cord-023095-4dannjjm 6756 14 was be VBD cord-023095-4dannjjm 6756 15 significantly significantly RB cord-023095-4dannjjm 6756 16 up up RB cord-023095-4dannjjm 6756 17 - - HYPH cord-023095-4dannjjm 6756 18 regulated regulate VBN cord-023095-4dannjjm 6756 19 in in IN cord-023095-4dannjjm 6756 20 BALF BALF NNP cord-023095-4dannjjm 6756 21 from from IN cord-023095-4dannjjm 6756 22 horses horse NNS cord-023095-4dannjjm 6756 23 with with IN cord-023095-4dannjjm 6756 24 IAD.Furthermore IAD.Furthermore NNP cord-023095-4dannjjm 6756 25 , , , cord-023095-4dannjjm 6756 26 the the DT cord-023095-4dannjjm 6756 27 BALF BALF NNP cord-023095-4dannjjm 6756 28 samples sample NNS cord-023095-4dannjjm 6756 29 were be VBD cord-023095-4dannjjm 6756 30 subdivided subdivide VBN cord-023095-4dannjjm 6756 31 in in IN cord-023095-4dannjjm 6756 32 two two CD cord-023095-4dannjjm 6756 33 groups group NNS cord-023095-4dannjjm 6756 34 based base VBN cord-023095-4dannjjm 6756 35 on on IN cord-023095-4dannjjm 6756 36 the the DT cord-023095-4dannjjm 6756 37 differential differential JJ cord-023095-4dannjjm 6756 38 cells cell NNS cord-023095-4dannjjm 6756 39 count count VBP cord-023095-4dannjjm 6756 40 1-BALF 1-balf CD cord-023095-4dannjjm 6756 41 with with IN cord-023095-4dannjjm 6756 42 increased increase VBN cord-023095-4dannjjm 6756 43 mast mast NN cord-023095-4dannjjm 6756 44 cells cell NNS cord-023095-4dannjjm 6756 45 ( ( -LRB- cord-023095-4dannjjm 6756 46 IAD IAD NNP cord-023095-4dannjjm 6756 47 - - HYPH cord-023095-4dannjjm 6756 48 Mast Mast NNP cord-023095-4dannjjm 6756 49 ) ) -RRB- cord-023095-4dannjjm 6756 50 and and CC cord-023095-4dannjjm 6756 51 2-BALF 2-balf CD cord-023095-4dannjjm 6756 52 with with IN cord-023095-4dannjjm 6756 53 increased increase VBN cord-023095-4dannjjm 6756 54 neutrophils neutrophil NNS cord-023095-4dannjjm 6756 55 ( ( -LRB- cord-023095-4dannjjm 6756 56 IAD IAD NNP cord-023095-4dannjjm 6756 57 - - HYPH cord-023095-4dannjjm 6756 58 Neutro Neutro NNP cord-023095-4dannjjm 6756 59 ) ) -RRB- cord-023095-4dannjjm 6756 60 . . . cord-023095-4dannjjm 6757 1 IL-4 IL-4 NNP cord-023095-4dannjjm 6757 2 was be VBD cord-023095-4dannjjm 6757 3 significantly significantly RB cord-023095-4dannjjm 6757 4 down down RB cord-023095-4dannjjm 6757 5 - - HYPH cord-023095-4dannjjm 6757 6 regulated regulate VBN cord-023095-4dannjjm 6757 7 in in IN cord-023095-4dannjjm 6757 8 the the DT cord-023095-4dannjjm 6757 9 IAD IAD NNP cord-023095-4dannjjm 6757 10 - - HYPH cord-023095-4dannjjm 6757 11 Neutro Neutro NNP cord-023095-4dannjjm 6757 12 group group NN cord-023095-4dannjjm 6757 13 compared compare VBN cord-023095-4dannjjm 6757 14 to to IN cord-023095-4dannjjm 6757 15 the the DT cord-023095-4dannjjm 6757 16 IAD IAD NNP cord-023095-4dannjjm 6757 17 - - HYPH cord-023095-4dannjjm 6757 18 Mast Mast NNP cord-023095-4dannjjm 6757 19 group group NN cord-023095-4dannjjm 6757 20 . . . cord-023095-4dannjjm 6758 1 IL-17 IL-17 NNP cord-023095-4dannjjm 6758 2 , , , cord-023095-4dannjjm 6759 1 IL-5 IL-5 NNP cord-023095-4dannjjm 6759 2 and and CC cord-023095-4dannjjm 6759 3 IL-8 IL-8 NNP cord-023095-4dannjjm 6759 4 were be VBD cord-023095-4dannjjm 6759 5 significantly significantly RB cord-023095-4dannjjm 6759 6 up up RB cord-023095-4dannjjm 6759 7 - - HYPH cord-023095-4dannjjm 6759 8 regulated regulate VBN cord-023095-4dannjjm 6759 9 in in IN cord-023095-4dannjjm 6759 10 the the DT cord-023095-4dannjjm 6759 11 IAD IAD NNP cord-023095-4dannjjm 6759 12 - - HYPH cord-023095-4dannjjm 6759 13 Neutro Neutro NNP cord-023095-4dannjjm 6759 14 group group NN cord-023095-4dannjjm 6759 15 compared compare VBN cord-023095-4dannjjm 6759 16 to to IN cord-023095-4dannjjm 6759 17 the the DT cord-023095-4dannjjm 6759 18 IAD IAD NNP cord-023095-4dannjjm 6759 19 - - HYPH cord-023095-4dannjjm 6759 20 Mast Mast NNP cord-023095-4dannjjm 6759 21 group group NN cord-023095-4dannjjm 6759 22 . . . cord-023095-4dannjjm 6760 1 The the DT cord-023095-4dannjjm 6760 2 present present JJ cord-023095-4dannjjm 6760 3 study study NN cord-023095-4dannjjm 6760 4 shows show VBZ cord-023095-4dannjjm 6760 5 that that IN cord-023095-4dannjjm 6760 6 IAD IAD NNP cord-023095-4dannjjm 6760 7 in in IN cord-023095-4dannjjm 6760 8 horses horse NNS cord-023095-4dannjjm 6760 9 is be VBZ cord-023095-4dannjjm 6760 10 characterized characterize VBN cord-023095-4dannjjm 6760 11 by by IN cord-023095-4dannjjm 6760 12 a a DT cord-023095-4dannjjm 6760 13 Th2 Th2 NNP cord-023095-4dannjjm 6760 14 and and CC cord-023095-4dannjjm 6760 15 a a DT cord-023095-4dannjjm 6760 16 Th17 Th17 NNP cord-023095-4dannjjm 6760 17 mRNA mrna NN cord-023095-4dannjjm 6760 18 inflammatory inflammatory JJ cord-023095-4dannjjm 6760 19 expression expression NN cord-023095-4dannjjm 6760 20 profile profile NN cord-023095-4dannjjm 6760 21 and and CC cord-023095-4dannjjm 6760 22 that that IN cord-023095-4dannjjm 6760 23 different different JJ cord-023095-4dannjjm 6760 24 immunological immunological JJ cord-023095-4dannjjm 6760 25 mechanisms mechanism NNS cord-023095-4dannjjm 6760 26 are be VBP cord-023095-4dannjjm 6760 27 involved involve VBN cord-023095-4dannjjm 6760 28 in in IN cord-023095-4dannjjm 6760 29 mast mast NN cord-023095-4dannjjm 6760 30 cells cell NNS cord-023095-4dannjjm 6760 31 or or CC cord-023095-4dannjjm 6760 32 neutrophils neutrophil NNS cord-023095-4dannjjm 6760 33 accumulation accumulation NN cord-023095-4dannjjm 6760 34 in in IN cord-023095-4dannjjm 6760 35 the the DT cord-023095-4dannjjm 6760 36 BALF BALF NNP cord-023095-4dannjjm 6760 37 of of IN cord-023095-4dannjjm 6760 38 horses horse NNS cord-023095-4dannjjm 6760 39 with with IN cord-023095-4dannjjm 6760 40 IAD IAD NNP cord-023095-4dannjjm 6760 41 . . . cord-023095-4dannjjm 6761 1 b b LS cord-023095-4dannjjm 6761 2 2 2 CD cord-023095-4dannjjm 6761 3 -adrenoreceptor -adrenoreceptor NNP cord-023095-4dannjjm 6761 4 ( ( -LRB- cord-023095-4dannjjm 6761 5 b b NN cord-023095-4dannjjm 6761 6 2 2 CD cord-023095-4dannjjm 6761 7 -AR -AR NNS cord-023095-4dannjjm 6761 8 ) ) -RRB- cord-023095-4dannjjm 6761 9 agonists agonist NNS cord-023095-4dannjjm 6761 10 are be VBP cord-023095-4dannjjm 6761 11 a a DT cord-023095-4dannjjm 6761 12 class class NN cord-023095-4dannjjm 6761 13 of of IN cord-023095-4dannjjm 6761 14 medications medication NNS cord-023095-4dannjjm 6761 15 that that WDT cord-023095-4dannjjm 6761 16 promote promote VBP cord-023095-4dannjjm 6761 17 smooth smooth JJ cord-023095-4dannjjm 6761 18 muscle muscle NN cord-023095-4dannjjm 6761 19 relaxation relaxation NN cord-023095-4dannjjm 6761 20 and and CC cord-023095-4dannjjm 6761 21 bronchodilation bronchodilation NN cord-023095-4dannjjm 6761 22 in in IN cord-023095-4dannjjm 6761 23 horses horse NNS cord-023095-4dannjjm 6761 24 and and CC cord-023095-4dannjjm 6761 25 humans human NNS cord-023095-4dannjjm 6761 26 with with IN cord-023095-4dannjjm 6761 27 airway airway NN cord-023095-4dannjjm 6761 28 disease disease NN cord-023095-4dannjjm 6761 29 . . . cord-023095-4dannjjm 6762 1 Activated activate VBN cord-023095-4dannjjm 6762 2 human human JJ cord-023095-4dannjjm 6762 3 peripheral peripheral JJ cord-023095-4dannjjm 6762 4 blood blood NN cord-023095-4dannjjm 6762 5 lymphocytes lymphocyte NNS cord-023095-4dannjjm 6762 6 ( ( -LRB- cord-023095-4dannjjm 6762 7 PBLs pbl NNS cord-023095-4dannjjm 6762 8 ) ) -RRB- cord-023095-4dannjjm 6762 9 also also RB cord-023095-4dannjjm 6762 10 respond respond VBP cord-023095-4dannjjm 6762 11 to to IN cord-023095-4dannjjm 6762 12 b b NN cord-023095-4dannjjm 6762 13 2 2 CD cord-023095-4dannjjm 6762 14 -AR -ar NN cord-023095-4dannjjm 6762 15 agonist agonist JJ cord-023095-4dannjjm 6762 16 stimulation stimulation NN cord-023095-4dannjjm 6762 17 by by IN cord-023095-4dannjjm 6762 18 attenuating attenuate VBG cord-023095-4dannjjm 6762 19 the the DT cord-023095-4dannjjm 6762 20 production production NN cord-023095-4dannjjm 6762 21 of of IN cord-023095-4dannjjm 6762 22 cytokines cytokine NNS cord-023095-4dannjjm 6762 23 associated associate VBN cord-023095-4dannjjm 6762 24 with with IN cord-023095-4dannjjm 6762 25 the the DT cord-023095-4dannjjm 6762 26 pathogenesis pathogenesis NN cord-023095-4dannjjm 6762 27 of of IN cord-023095-4dannjjm 6762 28 asthma asthma NN cord-023095-4dannjjm 6762 29 and and CC cord-023095-4dannjjm 6762 30 Recurrent Recurrent NNP cord-023095-4dannjjm 6762 31 Airway Airway NNP cord-023095-4dannjjm 6762 32 Obstruction obstruction NN cord-023095-4dannjjm 6762 33 ( ( -LRB- cord-023095-4dannjjm 6762 34 RAO RAO NNP cord-023095-4dannjjm 6762 35 ) ) -RRB- cord-023095-4dannjjm 6762 36 . . . cord-023095-4dannjjm 6763 1 The the DT cord-023095-4dannjjm 6763 2 aim aim NN cord-023095-4dannjjm 6763 3 of of IN cord-023095-4dannjjm 6763 4 this this DT cord-023095-4dannjjm 6763 5 study study NN cord-023095-4dannjjm 6763 6 was be VBD cord-023095-4dannjjm 6763 7 to to TO cord-023095-4dannjjm 6763 8 develop develop VB cord-023095-4dannjjm 6763 9 an an DT cord-023095-4dannjjm 6763 10 in in IN cord-023095-4dannjjm 6763 11 vitro vitro FW cord-023095-4dannjjm 6763 12 technique technique NN cord-023095-4dannjjm 6763 13 for for IN cord-023095-4dannjjm 6763 14 measuring measure VBG cord-023095-4dannjjm 6763 15 the the DT cord-023095-4dannjjm 6763 16 response response NN cord-023095-4dannjjm 6763 17 of of IN cord-023095-4dannjjm 6763 18 equine equine JJ cord-023095-4dannjjm 6763 19 PBLs pbl NNS cord-023095-4dannjjm 6763 20 to to IN cord-023095-4dannjjm 6763 21 stimulation stimulation NN cord-023095-4dannjjm 6763 22 with with IN cord-023095-4dannjjm 6763 23 Salbutamol Salbutamol NNP cord-023095-4dannjjm 6763 24 , , , cord-023095-4dannjjm 6763 25 a a DT cord-023095-4dannjjm 6763 26 b b NN cord-023095-4dannjjm 6763 27 2 2 CD cord-023095-4dannjjm 6763 28 -AR -ar NN cord-023095-4dannjjm 6763 29 agonist agonist NN cord-023095-4dannjjm 6763 30 . . . cord-023095-4dannjjm 6764 1 This this DT cord-023095-4dannjjm 6764 2 method method NN cord-023095-4dannjjm 6764 3 was be VBD cord-023095-4dannjjm 6764 4 then then RB cord-023095-4dannjjm 6764 5 used use VBN cord-023095-4dannjjm 6764 6 to to TO cord-023095-4dannjjm 6764 7 compare compare VB cord-023095-4dannjjm 6764 8 the the DT cord-023095-4dannjjm 6764 9 response response NN cord-023095-4dannjjm 6764 10 of of IN cord-023095-4dannjjm 6764 11 PBLs pbl NNS cord-023095-4dannjjm 6764 12 from from IN cord-023095-4dannjjm 6764 13 RAO RAO NNP cord-023095-4dannjjm 6764 14 - - HYPH cord-023095-4dannjjm 6764 15 affected affect VBN cord-023095-4dannjjm 6764 16 and and CC cord-023095-4dannjjm 6764 17 non non JJ cord-023095-4dannjjm 6764 18 - - JJ cord-023095-4dannjjm 6764 19 affected affected JJ cord-023095-4dannjjm 6764 20 horses horse NNS cord-023095-4dannjjm 6764 21 to to IN cord-023095-4dannjjm 6764 22 b b NN cord-023095-4dannjjm 6764 23 2 2 CD cord-023095-4dannjjm 6764 24 -AR -ar NN cord-023095-4dannjjm 6764 25 agonist agonist JJ cord-023095-4dannjjm 6764 26 stimulation stimulation NN cord-023095-4dannjjm 6764 27 . . . cord-023095-4dannjjm 6765 1 PBLs pbl NNS cord-023095-4dannjjm 6765 2 from from IN cord-023095-4dannjjm 6765 3 4 4 CD cord-023095-4dannjjm 6765 4 RAO RAO NNP cord-023095-4dannjjm 6765 5 and and CC cord-023095-4dannjjm 6765 6 4 4 CD cord-023095-4dannjjm 6765 7 nonaffected nonaffecte VBN cord-023095-4dannjjm 6765 8 horses horse NNS cord-023095-4dannjjm 6765 9 were be VBD cord-023095-4dannjjm 6765 10 cultured cultured JJ cord-023095-4dannjjm 6765 11 ( ( -LRB- cord-023095-4dannjjm 6765 12 4x10 4x10 CD cord-023095-4dannjjm 6765 13 6 6 CD cord-023095-4dannjjm 6765 14 /ml /ml . cord-023095-4dannjjm 6765 15 ) ) -RRB- cord-023095-4dannjjm 6765 16 in in IN cord-023095-4dannjjm 6765 17 RPMI RPMI NNP cord-023095-4dannjjm 6765 18 complete complete JJ cord-023095-4dannjjm 6765 19 media medium NNS cord-023095-4dannjjm 6765 20 with with IN cord-023095-4dannjjm 6765 21 Concanavalin Concanavalin NNP cord-023095-4dannjjm 6765 22 A A NNP cord-023095-4dannjjm 6765 23 ( ( -LRB- cord-023095-4dannjjm 6765 24 ConA ConA NNP cord-023095-4dannjjm 6765 25 , , , cord-023095-4dannjjm 6765 26 2ug/10 2ug/10 NNP cord-023095-4dannjjm 6765 27 6 6 CD cord-023095-4dannjjm 6765 28 cells cell NNS cord-023095-4dannjjm 6765 29 ) ) -RRB- cord-023095-4dannjjm 6765 30 for for IN cord-023095-4dannjjm 6765 31 0 0 CD cord-023095-4dannjjm 6765 32 , , , cord-023095-4dannjjm 6765 33 1 1 CD cord-023095-4dannjjm 6765 34 , , , cord-023095-4dannjjm 6765 35 or or CC cord-023095-4dannjjm 6765 36 2 2 CD cord-023095-4dannjjm 6765 37 days day NNS cord-023095-4dannjjm 6765 38 then then RB cord-023095-4dannjjm 6765 39 stimulated stimulate VBD cord-023095-4dannjjm 6765 40 with with IN cord-023095-4dannjjm 6765 41 Salbutamol Salbutamol NNP cord-023095-4dannjjm 6765 42 ( ( -LRB- cord-023095-4dannjjm 6765 43 30 30 CD cord-023095-4dannjjm 6765 44 minutes minute NNS cord-023095-4dannjjm 6765 45 ) ) -RRB- cord-023095-4dannjjm 6765 46 . . . cord-023095-4dannjjm 6766 1 Using use VBG cord-023095-4dannjjm 6766 2 flow flow NN cord-023095-4dannjjm 6766 3 cytometric cytometric NN cord-023095-4dannjjm 6766 4 techniques technique NNS cord-023095-4dannjjm 6766 5 , , , cord-023095-4dannjjm 6766 6 response response NN cord-023095-4dannjjm 6766 7 was be VBD cord-023095-4dannjjm 6766 8 measured measure VBN cord-023095-4dannjjm 6766 9 by by IN cord-023095-4dannjjm 6766 10 detecting detect VBG cord-023095-4dannjjm 6766 11 protein protein NN cord-023095-4dannjjm 6766 12 kinase kinase VBZ cord-023095-4dannjjm 6766 13 A a DT cord-023095-4dannjjm 6766 14 phosphorylation phosphorylation NN cord-023095-4dannjjm 6766 15 of of IN cord-023095-4dannjjm 6766 16 vasodilator vasodilator NN cord-023095-4dannjjm 6766 17 stimulated stimulate VBD cord-023095-4dannjjm 6766 18 phosphoprotein phosphoprotein NN cord-023095-4dannjjm 6766 19 ( ( -LRB- cord-023095-4dannjjm 6766 20 VASP VASP NNP cord-023095-4dannjjm 6766 21 ) ) -RRB- cord-023095-4dannjjm 6766 22 . . . cord-023095-4dannjjm 6767 1 Results result NNS cord-023095-4dannjjm 6767 2 were be VBD cord-023095-4dannjjm 6767 3 verified verify VBN cord-023095-4dannjjm 6767 4 by by IN cord-023095-4dannjjm 6767 5 western western JJ cord-023095-4dannjjm 6767 6 blot blot NN cord-023095-4dannjjm 6767 7 analysis analysis NN cord-023095-4dannjjm 6767 8 . . . cord-023095-4dannjjm 6768 1 Activated activated JJ cord-023095-4dannjjm 6768 2 PBLs pbl NNS cord-023095-4dannjjm 6768 3 were be VBD cord-023095-4dannjjm 6768 4 then then RB cord-023095-4dannjjm 6768 5 incubated incubate VBN cord-023095-4dannjjm 6768 6 with with IN cord-023095-4dannjjm 6768 7 ConA ConA NNP cord-023095-4dannjjm 6768 8 for for IN cord-023095-4dannjjm 6768 9 one one CD cord-023095-4dannjjm 6768 10 day day NN cord-023095-4dannjjm 6768 11 were be VBD cord-023095-4dannjjm 6768 12 pre pre VBN cord-023095-4dannjjm 6768 13 - - JJ cord-023095-4dannjjm 6768 14 incubated incubate VBN cord-023095-4dannjjm 6769 1 with with IN cord-023095-4dannjjm 6769 2 b b NN cord-023095-4dannjjm 6769 3 2 2 CD cord-023095-4dannjjm 6769 4 or or CC cord-023095-4dannjjm 6769 5 b b NN cord-023095-4dannjjm 6769 6 - - HYPH cord-023095-4dannjjm 6769 7 adrenoreceptor adrenoreceptor NN cord-023095-4dannjjm 6769 8 antagonist antagonist NN cord-023095-4dannjjm 6769 9 ( ( -LRB- cord-023095-4dannjjm 6769 10 ICI ICI NNP cord-023095-4dannjjm 6769 11 118,551 118,551 CD cord-023095-4dannjjm 6769 12 , , , cord-023095-4dannjjm 6769 13 Sigma Sigma NNP cord-023095-4dannjjm 6769 14 s s POS cord-023095-4dannjjm 6769 15 ; ; : cord-023095-4dannjjm 6769 16 Atenolol Atenolol NNP cord-023095-4dannjjm 6769 17 , , , cord-023095-4dannjjm 6769 18 Sigma Sigma NNP cord-023095-4dannjjm 6769 19 s s POS cord-023095-4dannjjm 6769 20 ) ) -RRB- cord-023095-4dannjjm 6769 21 for for IN cord-023095-4dannjjm 6769 22 15 15 CD cord-023095-4dannjjm 6769 23 minutes minute NNS cord-023095-4dannjjm 6769 24 , , , cord-023095-4dannjjm 6769 25 followed follow VBN cord-023095-4dannjjm 6769 26 by by IN cord-023095-4dannjjm 6769 27 30 30 CD cord-023095-4dannjjm 6769 28 minutes minute NNS cord-023095-4dannjjm 6769 29 Salbutamol Salbutamol NNP cord-023095-4dannjjm 6769 30 ( ( -LRB- cord-023095-4dannjjm 6769 31 500 500 CD cord-023095-4dannjjm 6769 32 nM nm NN cord-023095-4dannjjm 6769 33 ) ) -RRB- cord-023095-4dannjjm 6769 34 stimulation stimulation NN cord-023095-4dannjjm 6769 35 . . . cord-023095-4dannjjm 6770 1 Results result NNS cord-023095-4dannjjm 6770 2 were be VBD cord-023095-4dannjjm 6770 3 analyzed analyze VBN cord-023095-4dannjjm 6770 4 by by IN cord-023095-4dannjjm 6770 5 ANOVA ANOVA NNP cord-023095-4dannjjm 6770 6 or or CC cord-023095-4dannjjm 6770 7 ANCOVA ANCOVA NNP cord-023095-4dannjjm 6770 8 and and CC cord-023095-4dannjjm 6770 9 differences difference NNS cord-023095-4dannjjm 6770 10 were be VBD cord-023095-4dannjjm 6770 11 considered consider VBN cord-023095-4dannjjm 6770 12 significant significant JJ cord-023095-4dannjjm 6770 13 when when WRB cord-023095-4dannjjm 6770 14 p p NN cord-023095-4dannjjm 6770 15 o o NN cord-023095-4dannjjm 6770 16 0.05.Response 0.05.response NN cord-023095-4dannjjm 6770 17 to to IN cord-023095-4dannjjm 6770 18 b b NN cord-023095-4dannjjm 6770 19 - - HYPH cord-023095-4dannjjm 6770 20 antagonist antagonist NN cord-023095-4dannjjm 6770 21 was be VBD cord-023095-4dannjjm 6770 22 only only RB cord-023095-4dannjjm 6770 23 observed observe VBN cord-023095-4dannjjm 6770 24 in in IN cord-023095-4dannjjm 6770 25 activated activate VBN cord-023095-4dannjjm 6770 26 PBLs pbl NNS cord-023095-4dannjjm 6770 27 ( ( -LRB- cord-023095-4dannjjm 6770 28 pre pre JJ cord-023095-4dannjjm 6770 29 - - JJ cord-023095-4dannjjm 6770 30 cultured cultured JJ cord-023095-4dannjjm 6770 31 with with IN cord-023095-4dannjjm 6770 32 Con Con NNP cord-023095-4dannjjm 6770 33 A A NNP cord-023095-4dannjjm 6770 34 ) ) -RRB- cord-023095-4dannjjm 6770 35 and and CC cord-023095-4dannjjm 6770 36 was be VBD cord-023095-4dannjjm 6770 37 greater great JJR cord-023095-4dannjjm 6770 38 in in IN cord-023095-4dannjjm 6770 39 cells cell NNS cord-023095-4dannjjm 6770 40 from from IN cord-023095-4dannjjm 6770 41 RAO RAO NNP cord-023095-4dannjjm 6770 42 horses horse NNS cord-023095-4dannjjm 6770 43 as as IN cord-023095-4dannjjm 6770 44 compared compare VBN cord-023095-4dannjjm 6770 45 to to IN cord-023095-4dannjjm 6770 46 cells cell NNS cord-023095-4dannjjm 6770 47 from from IN cord-023095-4dannjjm 6770 48 non non JJ cord-023095-4dannjjm 6770 49 - - JJ cord-023095-4dannjjm 6770 50 affected affected JJ cord-023095-4dannjjm 6770 51 horses horse NNS cord-023095-4dannjjm 6770 52 . . . cord-023095-4dannjjm 6771 1 The the DT cord-023095-4dannjjm 6771 2 addition addition NN cord-023095-4dannjjm 6771 3 of of IN cord-023095-4dannjjm 6771 4 b b NN cord-023095-4dannjjm 6771 5 - - HYPH cord-023095-4dannjjm 6771 6 antagonist antagonist NN cord-023095-4dannjjm 6771 7 attenuated attenuate VBD cord-023095-4dannjjm 6771 8 the the DT cord-023095-4dannjjm 6771 9 response response NN cord-023095-4dannjjm 6771 10 of of IN cord-023095-4dannjjm 6771 11 PBLs pbl NNS cord-023095-4dannjjm 6771 12 to to IN cord-023095-4dannjjm 6771 13 Salbutamol Salbutamol NNP cord-023095-4dannjjm 6771 14 while while IN cord-023095-4dannjjm 6771 15 the the DT cord-023095-4dannjjm 6771 16 addition addition NN cord-023095-4dannjjm 6771 17 of of IN cord-023095-4dannjjm 6771 18 a a DT cord-023095-4dannjjm 6771 19 b b NN cord-023095-4dannjjm 6771 20 1 1 CD cord-023095-4dannjjm 6771 21 -antagonist -antagonist SYM cord-023095-4dannjjm 6771 22 had have VBD cord-023095-4dannjjm 6771 23 no no DT cord-023095-4dannjjm 6771 24 effect effect NN cord-023095-4dannjjm 6771 25 . . . cord-023095-4dannjjm 6772 1 These these DT cord-023095-4dannjjm 6772 2 findings finding NNS cord-023095-4dannjjm 6772 3 indicate indicate VBP cord-023095-4dannjjm 6772 4 that that IN cord-023095-4dannjjm 6772 5 activated activate VBN cord-023095-4dannjjm 6772 6 PBLs pbl NNS cord-023095-4dannjjm 6772 7 from from IN cord-023095-4dannjjm 6772 8 RAO RAO NNP cord-023095-4dannjjm 6772 9 - - HYPH cord-023095-4dannjjm 6772 10 affected affect VBN cord-023095-4dannjjm 6772 11 horses horse NNS cord-023095-4dannjjm 6772 12 have have VBP cord-023095-4dannjjm 6772 13 a a DT cord-023095-4dannjjm 6772 14 greater great JJR cord-023095-4dannjjm 6772 15 response response NN cord-023095-4dannjjm 6772 16 to to IN cord-023095-4dannjjm 6772 17 Salbutamol Salbutamol NNP cord-023095-4dannjjm 6772 18 as as IN cord-023095-4dannjjm 6772 19 compared compare VBN cord-023095-4dannjjm 6772 20 to to IN cord-023095-4dannjjm 6772 21 PBLs pbl NNS cord-023095-4dannjjm 6772 22 from from IN cord-023095-4dannjjm 6772 23 non non JJ cord-023095-4dannjjm 6772 24 - - JJ cord-023095-4dannjjm 6772 25 affected affected JJ cord-023095-4dannjjm 6772 26 horses horse NNS cord-023095-4dannjjm 6772 27 , , , cord-023095-4dannjjm 6772 28 and and CC cord-023095-4dannjjm 6772 29 this this DT cord-023095-4dannjjm 6772 30 response response NN cord-023095-4dannjjm 6772 31 is be VBZ cord-023095-4dannjjm 6772 32 mediated mediate VBN cord-023095-4dannjjm 6772 33 mainly mainly RB cord-023095-4dannjjm 6772 34 through through IN cord-023095-4dannjjm 6772 35 the the DT cord-023095-4dannjjm 6772 36 b b NN cord-023095-4dannjjm 6772 37 2 2 CD cord-023095-4dannjjm 6772 38 -AR.Human -ar.human NN cord-023095-4dannjjm 6772 39 b b NN cord-023095-4dannjjm 6772 40 2 2 CD cord-023095-4dannjjm 6772 41 -AR -AR NNS cord-023095-4dannjjm 6772 42 are be VBP cord-023095-4dannjjm 6772 43 known know VBN cord-023095-4dannjjm 6772 44 be be VB cord-023095-4dannjjm 6772 45 polymorphic polymorphic JJ cord-023095-4dannjjm 6772 46 and and CC cord-023095-4dannjjm 6772 47 this this DT cord-023095-4dannjjm 6772 48 polymorphism polymorphism NN cord-023095-4dannjjm 6772 49 results result VBZ cord-023095-4dannjjm 6772 50 in in IN cord-023095-4dannjjm 6772 51 a a DT cord-023095-4dannjjm 6772 52 variable variable JJ cord-023095-4dannjjm 6772 53 response response NN cord-023095-4dannjjm 6772 54 to to IN cord-023095-4dannjjm 6772 55 b b NN cord-023095-4dannjjm 6772 56 2 2 CD cord-023095-4dannjjm 6772 57 -agonist -agonist NN cord-023095-4dannjjm 6772 58 binding binding NN cord-023095-4dannjjm 6772 59 that that WDT cord-023095-4dannjjm 6772 60 affects affect VBZ cord-023095-4dannjjm 6772 61 long long JJ cord-023095-4dannjjm 6772 62 term term NN cord-023095-4dannjjm 6772 63 outcome outcome NN cord-023095-4dannjjm 6772 64 in in IN cord-023095-4dannjjm 6772 65 human human JJ cord-023095-4dannjjm 6772 66 asthmatics asthmatic NNS cord-023095-4dannjjm 6772 67 . . . cord-023095-4dannjjm 6773 1 Further further JJ cord-023095-4dannjjm 6773 2 studies study NNS cord-023095-4dannjjm 6773 3 are be VBP cord-023095-4dannjjm 6773 4 required require VBN cord-023095-4dannjjm 6773 5 to to TO cord-023095-4dannjjm 6773 6 determine determine VB cord-023095-4dannjjm 6773 7 if if IN cord-023095-4dannjjm 6773 8 the the DT cord-023095-4dannjjm 6773 9 difference difference NN cord-023095-4dannjjm 6773 10 in in IN cord-023095-4dannjjm 6773 11 response response NN cord-023095-4dannjjm 6773 12 of of IN cord-023095-4dannjjm 6773 13 PBLs pbl NNS cord-023095-4dannjjm 6773 14 from from IN cord-023095-4dannjjm 6773 15 RAO RAO NNP cord-023095-4dannjjm 6773 16 affected affect VBD cord-023095-4dannjjm 6773 17 as as IN cord-023095-4dannjjm 6773 18 compared compare VBN cord-023095-4dannjjm 6773 19 to to IN cord-023095-4dannjjm 6773 20 non non JJ cord-023095-4dannjjm 6773 21 - - JJ cord-023095-4dannjjm 6773 22 affected affected JJ cord-023095-4dannjjm 6773 23 horses horse NNS cord-023095-4dannjjm 6773 24 is be VBZ cord-023095-4dannjjm 6773 25 due due JJ cord-023095-4dannjjm 6773 26 to to IN cord-023095-4dannjjm 6773 27 genetic genetic JJ cord-023095-4dannjjm 6773 28 polymorphism polymorphism NN cord-023095-4dannjjm 6773 29 in in IN cord-023095-4dannjjm 6773 30 the the DT cord-023095-4dannjjm 6773 31 equine equine NN cord-023095-4dannjjm 6773 32 b b NN cord-023095-4dannjjm 6773 33 2 2 CD cord-023095-4dannjjm 6773 34 -AR -AR NNS cord-023095-4dannjjm 6773 35 , , , cord-023095-4dannjjm 6773 36 and and CC cord-023095-4dannjjm 6773 37 whether whether IN cord-023095-4dannjjm 6773 38 this this DT cord-023095-4dannjjm 6773 39 difference difference NN cord-023095-4dannjjm 6773 40 is be VBZ cord-023095-4dannjjm 6773 41 associated associate VBN cord-023095-4dannjjm 6773 42 with with IN cord-023095-4dannjjm 6773 43 a a DT cord-023095-4dannjjm 6773 44 propensity propensity NN cord-023095-4dannjjm 6773 45 for for IN cord-023095-4dannjjm 6773 46 horses horse NNS cord-023095-4dannjjm 6773 47 to to TO cord-023095-4dannjjm 6773 48 develop develop VB cord-023095-4dannjjm 6773 49 equine equine JJ cord-023095-4dannjjm 6773 50 RAO RAO NNP cord-023095-4dannjjm 6773 51 . . .