id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-009877-3cyz6o9c	Barclay, Wendy S.	Evaluation of an enzyme‐linked immunosorbent assay that measures rhinovirus‐specific antibodies in human sera and nasal secretions	2005-12-07		.txt	text/plain	3078	144	47	In a preliminary study involving 12 volunteers inoculated intranasally with human rhinovirus EL (HRV-EL), we showed that the presence of circulating rhinovirus-specific IgA, rather than IgG, protected volunteers from infection [Barclay and Al-Nakib, 19871. Figure 1 shows a) the mean HRV-2-neutralising antibody, b) specific IgG and c) IgA in the serum, and d) specific IgA in nasal secretions (normalized for total IgA) in pre-inoculation samples from the three groups of volunteers. Recently, a similar study involving samples obtained from volunteers inoculated with another rhinovirus serotype (HRV-9) and tested by ELISA for homologous antibodies, appears to confirm the association between ELISA-serumspecific IgA and protection against reinfection (Callow and Sergeant, unpublished data). The size of rises in HRV-2-specific IgA in the serum after virus inoculation showed a significant negative correlation with the concentration of specific IgA in the pre-inoculation nasal secretions and with the presence of serum neutralising antibody, indicating that volunteers who were most susceptible to infection and illness, in fact, showed the largest antibody response.	./cache/cord-009877-3cyz6o9c.txt	./txt/cord-009877-3cyz6o9c.txt