id sid tid token lemma pos cord-344988-09vpehvf 1 1 key key JJ cord-344988-09vpehvf 1 2 : : : cord-344988-09vpehvf 1 3 cord-344988 cord-344988 NN cord-344988-09vpehvf 1 4 - - HYPH cord-344988-09vpehvf 1 5 09vpehvf 09vpehvf CD cord-344988-09vpehvf 1 6 authors author NNS cord-344988-09vpehvf 1 7 : : : cord-344988-09vpehvf 2 1 Overbeck Overbeck NNP cord-344988-09vpehvf 2 2 , , , cord-344988-09vpehvf 2 3 Silke Silke NNP cord-344988-09vpehvf 2 4 ; ; : cord-344988-09vpehvf 2 5 Rink Rink NNP cord-344988-09vpehvf 2 6 , , , cord-344988-09vpehvf 2 7 Lothar Lothar NNP cord-344988-09vpehvf 2 8 ; ; : cord-344988-09vpehvf 2 9 Haase Haase NNP cord-344988-09vpehvf 2 10 , , , cord-344988-09vpehvf 2 11 Hajo Hajo NNP cord-344988-09vpehvf 2 12 title title NN cord-344988-09vpehvf 2 13 : : : cord-344988-09vpehvf 3 1 Modulating modulate VBG cord-344988-09vpehvf 3 2 the the DT cord-344988-09vpehvf 3 3 immune immune JJ cord-344988-09vpehvf 3 4 response response NN cord-344988-09vpehvf 3 5 by by IN cord-344988-09vpehvf 3 6 oral oral JJ cord-344988-09vpehvf 3 7 zinc zinc NN cord-344988-09vpehvf 3 8 supplementation supplementation NN cord-344988-09vpehvf 3 9 : : : cord-344988-09vpehvf 3 10 a a DT cord-344988-09vpehvf 3 11 single single JJ cord-344988-09vpehvf 3 12 approach approach NN cord-344988-09vpehvf 3 13 for for IN cord-344988-09vpehvf 3 14 multiple multiple JJ cord-344988-09vpehvf 3 15 diseases disease NNS cord-344988-09vpehvf 3 16 date date NN cord-344988-09vpehvf 4 1 : : : cord-344988-09vpehvf 4 2 2008 2008 CD cord-344988-09vpehvf 4 3 - - SYM cord-344988-09vpehvf 4 4 02 02 CD cord-344988-09vpehvf 4 5 - - HYPH cord-344988-09vpehvf 4 6 05 05 CD cord-344988-09vpehvf 4 7 journal journal NN cord-344988-09vpehvf 4 8 : : : cord-344988-09vpehvf 5 1 Arch Arch NNP cord-344988-09vpehvf 5 2 Immunol Immunol NNP cord-344988-09vpehvf 5 3 Ther Ther NNP cord-344988-09vpehvf 5 4 Exp Exp NNP cord-344988-09vpehvf 5 5 ( ( -LRB- cord-344988-09vpehvf 5 6 Warsz Warsz NNP cord-344988-09vpehvf 5 7 ) ) -RRB- cord-344988-09vpehvf 5 8 DOI DOI NNP cord-344988-09vpehvf 5 9 : : : cord-344988-09vpehvf 5 10 10.1007 10.1007 CD cord-344988-09vpehvf 5 11 / / SYM cord-344988-09vpehvf 5 12 s00005 s00005 NNP cord-344988-09vpehvf 5 13 - - HYPH cord-344988-09vpehvf 5 14 008 008 CD cord-344988-09vpehvf 5 15 - - HYPH cord-344988-09vpehvf 5 16 0003 0003 CD cord-344988-09vpehvf 5 17 - - SYM cord-344988-09vpehvf 5 18 8 8 CD cord-344988-09vpehvf 5 19 sha sha NN cord-344988-09vpehvf 5 20 : : : cord-344988-09vpehvf 5 21 f85d33b30f4c9821c4c9d16f0712c4a2c25204ff f85d33b30f4c9821c4c9d16f0712c4a2c25204ff NNP cord-344988-09vpehvf 5 22 doc_id doc_id NNP cord-344988-09vpehvf 5 23 : : : cord-344988-09vpehvf 5 24 344988 344988 CD cord-344988-09vpehvf 6 1 cord_uid cord_uid NNS cord-344988-09vpehvf 6 2 : : : cord-344988-09vpehvf 6 3 09vpehvf 09vpehvf CD cord-344988-09vpehvf 7 1 Zinc zinc NN cord-344988-09vpehvf 7 2 is be VBZ cord-344988-09vpehvf 7 3 required require VBN cord-344988-09vpehvf 7 4 for for IN cord-344988-09vpehvf 7 5 multiple multiple JJ cord-344988-09vpehvf 7 6 cellular cellular JJ cord-344988-09vpehvf 7 7 tasks task NNS cord-344988-09vpehvf 7 8 , , , cord-344988-09vpehvf 7 9 and and CC cord-344988-09vpehvf 7 10 especially especially RB cord-344988-09vpehvf 7 11 the the DT cord-344988-09vpehvf 7 12 immune immune JJ cord-344988-09vpehvf 7 13 system system NN cord-344988-09vpehvf 7 14 depends depend VBZ cord-344988-09vpehvf 7 15 on on IN cord-344988-09vpehvf 7 16 a a DT cord-344988-09vpehvf 7 17 sufficient sufficient JJ cord-344988-09vpehvf 7 18 availability availability NN cord-344988-09vpehvf 7 19 of of IN cord-344988-09vpehvf 7 20 this this DT cord-344988-09vpehvf 7 21 essential essential JJ cord-344988-09vpehvf 7 22 trace trace NN cord-344988-09vpehvf 7 23 element element NN cord-344988-09vpehvf 7 24 . . . cord-344988-09vpehvf 8 1 During during IN cord-344988-09vpehvf 8 2 the the DT cord-344988-09vpehvf 8 3 last last JJ cord-344988-09vpehvf 8 4 decades decade NNS cord-344988-09vpehvf 8 5 , , , cord-344988-09vpehvf 8 6 many many JJ cord-344988-09vpehvf 8 7 studies study NNS cord-344988-09vpehvf 8 8 attempted attempt VBD cord-344988-09vpehvf 8 9 to to TO cord-344988-09vpehvf 8 10 affect affect VB cord-344988-09vpehvf 8 11 the the DT cord-344988-09vpehvf 8 12 outcome outcome NN cord-344988-09vpehvf 8 13 of of IN cord-344988-09vpehvf 8 14 various various JJ cord-344988-09vpehvf 8 15 diseases disease NNS cord-344988-09vpehvf 8 16 by by IN cord-344988-09vpehvf 8 17 zinc zinc NN cord-344988-09vpehvf 8 18 supplementation supplementation NN cord-344988-09vpehvf 8 19 . . . cord-344988-09vpehvf 9 1 These these DT cord-344988-09vpehvf 9 2 efforts effort NNS cord-344988-09vpehvf 9 3 either either CC cord-344988-09vpehvf 9 4 aimed aim VBN cord-344988-09vpehvf 9 5 at at IN cord-344988-09vpehvf 9 6 supporting support VBG cord-344988-09vpehvf 9 7 immunity immunity NN cord-344988-09vpehvf 9 8 by by IN cord-344988-09vpehvf 9 9 zinc zinc NN cord-344988-09vpehvf 9 10 administration administration NN cord-344988-09vpehvf 9 11 or or CC cord-344988-09vpehvf 9 12 at at IN cord-344988-09vpehvf 9 13 correcting correct VBG cord-344988-09vpehvf 9 14 a a DT cord-344988-09vpehvf 9 15 loss loss NN cord-344988-09vpehvf 9 16 of of IN cord-344988-09vpehvf 9 17 zinc zinc NN cord-344988-09vpehvf 9 18 secondary secondary JJ cord-344988-09vpehvf 9 19 to to IN cord-344988-09vpehvf 9 20 the the DT cord-344988-09vpehvf 9 21 disease disease NN cord-344988-09vpehvf 9 22 to to TO cord-344988-09vpehvf 9 23 restore restore VB cord-344988-09vpehvf 9 24 the the DT cord-344988-09vpehvf 9 25 zinc zinc NN cord-344988-09vpehvf 9 26 - - HYPH cord-344988-09vpehvf 9 27 dependent dependent JJ cord-344988-09vpehvf 9 28 functions function NNS cord-344988-09vpehvf 9 29 of of IN cord-344988-09vpehvf 9 30 the the DT cord-344988-09vpehvf 9 31 immune immune JJ cord-344988-09vpehvf 9 32 system system NN cord-344988-09vpehvf 9 33 . . . cord-344988-09vpehvf 10 1 This this DT cord-344988-09vpehvf 10 2 review review NN cord-344988-09vpehvf 10 3 aims aim VBZ cord-344988-09vpehvf 10 4 to to TO cord-344988-09vpehvf 10 5 summarize summarize VB cord-344988-09vpehvf 10 6 the the DT cord-344988-09vpehvf 10 7 respective respective JJ cord-344988-09vpehvf 10 8 findings finding NNS cord-344988-09vpehvf 10 9 and and CC cord-344988-09vpehvf 10 10 to to TO cord-344988-09vpehvf 10 11 discuss discuss VB cord-344988-09vpehvf 10 12 possible possible JJ cord-344988-09vpehvf 10 13 molecular molecular JJ cord-344988-09vpehvf 10 14 mechanisms mechanism NNS cord-344988-09vpehvf 10 15 by by IN cord-344988-09vpehvf 10 16 which which WDT cord-344988-09vpehvf 10 17 zinc zinc NN cord-344988-09vpehvf 10 18 could could MD cord-344988-09vpehvf 10 19 influence influence VB cord-344988-09vpehvf 10 20 viral viral JJ cord-344988-09vpehvf 10 21 , , , cord-344988-09vpehvf 10 22 bacterial bacterial JJ cord-344988-09vpehvf 10 23 , , , cord-344988-09vpehvf 10 24 and and CC cord-344988-09vpehvf 10 25 parasitic parasitic JJ cord-344988-09vpehvf 10 26 infections infection NNS cord-344988-09vpehvf 10 27 , , , cord-344988-09vpehvf 10 28 autoimmune autoimmune JJ cord-344988-09vpehvf 10 29 diseases disease NNS cord-344988-09vpehvf 10 30 , , , cord-344988-09vpehvf 10 31 and and CC cord-344988-09vpehvf 10 32 the the DT cord-344988-09vpehvf 10 33 response response NN cord-344988-09vpehvf 10 34 to to IN cord-344988-09vpehvf 10 35 vaccination vaccination NN cord-344988-09vpehvf 10 36 . . . cord-344988-09vpehvf 11 1 Zinc zinc NN cord-344988-09vpehvf 11 2 supplementation supplementation NN cord-344988-09vpehvf 11 3 in in IN cord-344988-09vpehvf 11 4 diseases disease NNS cord-344988-09vpehvf 11 5 such such JJ cord-344988-09vpehvf 11 6 as as IN cord-344988-09vpehvf 11 7 diarrhea diarrhea NN cord-344988-09vpehvf 11 8 , , , cord-344988-09vpehvf 11 9 chronic chronic JJ cord-344988-09vpehvf 11 10 hepatitis hepatitis NN cord-344988-09vpehvf 11 11 C C NNP cord-344988-09vpehvf 11 12 , , , cord-344988-09vpehvf 11 13 shigellosis shigellosis NN cord-344988-09vpehvf 11 14 , , , cord-344988-09vpehvf 11 15 leprosy leprosy NN cord-344988-09vpehvf 11 16 , , , cord-344988-09vpehvf 11 17 tuberculosis tuberculosis NN cord-344988-09vpehvf 11 18 , , , cord-344988-09vpehvf 11 19 pneumonia pneumonia NN cord-344988-09vpehvf 11 20 , , , cord-344988-09vpehvf 11 21 acute acute JJ cord-344988-09vpehvf 11 22 lower low JJR cord-344988-09vpehvf 11 23 respiratory respiratory JJ cord-344988-09vpehvf 11 24 infection infection NN cord-344988-09vpehvf 11 25 , , , cord-344988-09vpehvf 11 26 and and CC cord-344988-09vpehvf 11 27 leishmaniasis leishmaniasis NN cord-344988-09vpehvf 11 28 seems seem VBZ cord-344988-09vpehvf 11 29 beneficial beneficial JJ cord-344988-09vpehvf 11 30 . . . cord-344988-09vpehvf 12 1 In in IN cord-344988-09vpehvf 12 2 contrast contrast NN cord-344988-09vpehvf 12 3 , , , cord-344988-09vpehvf 12 4 the the DT cord-344988-09vpehvf 12 5 results result NNS cord-344988-09vpehvf 12 6 for for IN cord-344988-09vpehvf 12 7 the the DT cord-344988-09vpehvf 12 8 common common JJ cord-344988-09vpehvf 12 9 cold cold NN cord-344988-09vpehvf 12 10 and and CC cord-344988-09vpehvf 12 11 malaria malaria NN cord-344988-09vpehvf 12 12 are be VBP cord-344988-09vpehvf 12 13 still still RB cord-344988-09vpehvf 12 14 not not RB cord-344988-09vpehvf 12 15 conclusive conclusive JJ cord-344988-09vpehvf 12 16 , , , cord-344988-09vpehvf 12 17 and and CC cord-344988-09vpehvf 12 18 zinc zinc NN cord-344988-09vpehvf 12 19 was be VBD cord-344988-09vpehvf 12 20 ineffective ineffective JJ cord-344988-09vpehvf 12 21 in in IN cord-344988-09vpehvf 12 22 most most JJS cord-344988-09vpehvf 12 23 vaccination vaccination NN cord-344988-09vpehvf 12 24 and and CC cord-344988-09vpehvf 12 25 rheumatoid rheumatoid NN cord-344988-09vpehvf 12 26 arthritis arthritis NN cord-344988-09vpehvf 12 27 studies study NNS cord-344988-09vpehvf 12 28 . . . cord-344988-09vpehvf 13 1 For for IN cord-344988-09vpehvf 13 2 AIDS AIDS NNP cord-344988-09vpehvf 13 3 and and CC cord-344988-09vpehvf 13 4 type type NN cord-344988-09vpehvf 13 5 1 1 CD cord-344988-09vpehvf 13 6 diabetes diabetes NN cord-344988-09vpehvf 13 7 , , , cord-344988-09vpehvf 13 8 zinc zinc NN cord-344988-09vpehvf 13 9 supplementation supplementation NN cord-344988-09vpehvf 13 10 may may MD cord-344988-09vpehvf 13 11 even even RB cord-344988-09vpehvf 13 12 be be VB cord-344988-09vpehvf 13 13 a a DT cord-344988-09vpehvf 13 14 risk risk NN cord-344988-09vpehvf 13 15 factor factor NN cord-344988-09vpehvf 13 16 for for IN cord-344988-09vpehvf 13 17 increased increase VBN cord-344988-09vpehvf 13 18 mortality mortality NN cord-344988-09vpehvf 13 19 or or CC cord-344988-09vpehvf 13 20 deterioration deterioration NN cord-344988-09vpehvf 13 21 of of IN cord-344988-09vpehvf 13 22 the the DT cord-344988-09vpehvf 13 23 glucose glucose NN cord-344988-09vpehvf 13 24 metabolism metabolism NN cord-344988-09vpehvf 13 25 , , , cord-344988-09vpehvf 13 26 respectively respectively RB cord-344988-09vpehvf 13 27 . . . cord-344988-09vpehvf 14 1 In in IN cord-344988-09vpehvf 14 2 these these DT cord-344988-09vpehvf 14 3 cases case NNS cord-344988-09vpehvf 14 4 , , , cord-344988-09vpehvf 14 5 zinc zinc NN cord-344988-09vpehvf 14 6 supplementation supplementation NN cord-344988-09vpehvf 14 7 should should MD cord-344988-09vpehvf 14 8 be be VB cord-344988-09vpehvf 14 9 used use VBN cord-344988-09vpehvf 14 10 with with IN cord-344988-09vpehvf 14 11 care care NN cord-344988-09vpehvf 14 12 and and CC cord-344988-09vpehvf 14 13 limited limit VBN cord-344988-09vpehvf 14 14 to to TO cord-344988-09vpehvf 14 15 clearly clearly RB cord-344988-09vpehvf 14 16 zinc zinc NN cord-344988-09vpehvf 14 17 - - HYPH cord-344988-09vpehvf 14 18 deficient deficient JJ cord-344988-09vpehvf 14 19 individuals individual NNS cord-344988-09vpehvf 14 20 . . . cord-344988-09vpehvf 15 1 In in IN cord-344988-09vpehvf 15 2 1963 1963 CD cord-344988-09vpehvf 15 3 , , , cord-344988-09vpehvf 15 4 the the DT cord-344988-09vpehvf 15 5 severe severe JJ cord-344988-09vpehvf 15 6 consequences consequence NNS cord-344988-09vpehvf 15 7 of of IN cord-344988-09vpehvf 15 8 zinc zinc NN cord-344988-09vpehvf 15 9 deficiency deficiency NN cord-344988-09vpehvf 15 10 in in IN cord-344988-09vpehvf 15 11 humans human NNS cord-344988-09vpehvf 15 12 were be VBD cord-344988-09vpehvf 15 13 first first RB cord-344988-09vpehvf 15 14 described describe VBN cord-344988-09vpehvf 15 15 by by IN cord-344988-09vpehvf 15 16 Prasad Prasad NNP cord-344988-09vpehvf 15 17 et et NNP cord-344988-09vpehvf 15 18 al al NNP cord-344988-09vpehvf 15 19 . . . cord-344988-09vpehvf 16 1 [ [ -LRB- cord-344988-09vpehvf 16 2 121 121 CD cord-344988-09vpehvf 16 3 ] ] -RRB- cord-344988-09vpehvf 16 4 . . . cord-344988-09vpehvf 17 1 Since since IN cord-344988-09vpehvf 17 2 then then RB cord-344988-09vpehvf 17 3 , , , cord-344988-09vpehvf 17 4 large large JJ cord-344988-09vpehvf 17 5 parts part NNS cord-344988-09vpehvf 17 6 of of IN cord-344988-09vpehvf 17 7 the the DT cord-344988-09vpehvf 17 8 molecular molecular JJ cord-344988-09vpehvf 17 9 basis basis NN cord-344988-09vpehvf 17 10 for for IN cord-344988-09vpehvf 17 11 the the DT cord-344988-09vpehvf 17 12 essentiality essentiality NN cord-344988-09vpehvf 17 13 of of IN cord-344988-09vpehvf 17 14 zinc zinc NN cord-344988-09vpehvf 17 15 have have VBP cord-344988-09vpehvf 17 16 been be VBN cord-344988-09vpehvf 17 17 identified identify VBN cord-344988-09vpehvf 17 18 . . . cord-344988-09vpehvf 18 1 It -PRON- PRP cord-344988-09vpehvf 18 2 was be VBD cord-344988-09vpehvf 18 3 shown show VBN cord-344988-09vpehvf 18 4 that that IN cord-344988-09vpehvf 18 5 it -PRON- PRP cord-344988-09vpehvf 18 6 is be VBZ cord-344988-09vpehvf 18 7 a a DT cord-344988-09vpehvf 18 8 component component NN cord-344988-09vpehvf 18 9 of of IN cord-344988-09vpehvf 18 10 more more JJR cord-344988-09vpehvf 18 11 than than IN cord-344988-09vpehvf 18 12 300 300 CD cord-344988-09vpehvf 18 13 enzymes enzyme NNS cord-344988-09vpehvf 18 14 from from IN cord-344988-09vpehvf 18 15 all all DT cord-344988-09vpehvf 18 16 six six CD cord-344988-09vpehvf 18 17 classes class NNS cord-344988-09vpehvf 18 18 [ [ -LRB- cord-344988-09vpehvf 18 19 160 160 CD cord-344988-09vpehvf 18 20 ] ] -RRB- cord-344988-09vpehvf 18 21 , , , cord-344988-09vpehvf 18 22 where where WRB cord-344988-09vpehvf 18 23 it -PRON- PRP cord-344988-09vpehvf 18 24 acts act VBZ cord-344988-09vpehvf 18 25 as as IN cord-344988-09vpehvf 18 26 a a DT cord-344988-09vpehvf 18 27 catalytic catalytic JJ cord-344988-09vpehvf 18 28 , , , cord-344988-09vpehvf 18 29 cocatalytic cocatalytic JJ cord-344988-09vpehvf 18 30 , , , cord-344988-09vpehvf 18 31 structural structural JJ cord-344988-09vpehvf 18 32 , , , cord-344988-09vpehvf 18 33 or or CC cord-344988-09vpehvf 18 34 regulatory regulatory JJ cord-344988-09vpehvf 18 35 ion ion NN cord-344988-09vpehvf 18 36 . . . cord-344988-09vpehvf 19 1 Zinc zinc NN cord-344988-09vpehvf 19 2 - - HYPH cord-344988-09vpehvf 19 3 dependent dependent JJ cord-344988-09vpehvf 19 4 biological biological JJ cord-344988-09vpehvf 19 5 functions function NNS cord-344988-09vpehvf 19 6 include include VBP cord-344988-09vpehvf 19 7 DNA dna NN cord-344988-09vpehvf 19 8 replication replication NN cord-344988-09vpehvf 19 9 [ [ -LRB- cord-344988-09vpehvf 19 10 173 173 CD cord-344988-09vpehvf 19 11 ] ] -RRB- cord-344988-09vpehvf 19 12 , , , cord-344988-09vpehvf 19 13 RNA RNA NNP cord-344988-09vpehvf 19 14 transcription transcription NN cord-344988-09vpehvf 19 15 [ [ -LRB- cord-344988-09vpehvf 19 16 31 31 CD cord-344988-09vpehvf 19 17 , , , cord-344988-09vpehvf 19 18 38 38 CD cord-344988-09vpehvf 19 19 , , , cord-344988-09vpehvf 19 20 173 173 CD cord-344988-09vpehvf 19 21 ] ] -RRB- cord-344988-09vpehvf 19 22 , , , cord-344988-09vpehvf 19 23 signal signal NN cord-344988-09vpehvf 19 24 transduction transduction NN cord-344988-09vpehvf 19 25 [ [ -LRB- cord-344988-09vpehvf 19 26 13 13 CD cord-344988-09vpehvf 19 27 ] ] -RRB- cord-344988-09vpehvf 19 28 , , , cord-344988-09vpehvf 19 29 enzymatic enzymatic JJ cord-344988-09vpehvf 19 30 catalysis catalysis NN cord-344988-09vpehvf 19 31 [ [ -LRB- cord-344988-09vpehvf 19 32 7 7 CD cord-344988-09vpehvf 19 33 ] ] -RRB- cord-344988-09vpehvf 19 34 , , , cord-344988-09vpehvf 19 35 redox redox NN cord-344988-09vpehvf 19 36 regulation regulation NN cord-344988-09vpehvf 19 37 [ [ -LRB- cord-344988-09vpehvf 19 38 87 87 CD cord-344988-09vpehvf 19 39 ] ] -RRB- cord-344988-09vpehvf 19 40 , , , cord-344988-09vpehvf 19 41 cell cell NN cord-344988-09vpehvf 19 42 proliferation proliferation NN cord-344988-09vpehvf 19 43 [ [ -LRB- cord-344988-09vpehvf 19 44 17 17 CD cord-344988-09vpehvf 19 45 , , , cord-344988-09vpehvf 19 46 55 55 CD cord-344988-09vpehvf 19 47 , , , cord-344988-09vpehvf 19 48 83 83 CD cord-344988-09vpehvf 19 49 , , , cord-344988-09vpehvf 19 50 119 119 CD cord-344988-09vpehvf 19 51 ] ] -RRB- cord-344988-09vpehvf 19 52 , , , cord-344988-09vpehvf 19 53 cell cell NN cord-344988-09vpehvf 19 54 differentiation differentiation NN cord-344988-09vpehvf 19 55 [ [ -LRB- cord-344988-09vpehvf 19 56 112 112 CD cord-344988-09vpehvf 19 57 ] ] -RRB- cord-344988-09vpehvf 19 58 , , , cord-344988-09vpehvf 19 59 and and CC cord-344988-09vpehvf 19 60 apoptosis apoptosis NN cord-344988-09vpehvf 19 61 [ [ -LRB- cord-344988-09vpehvf 19 62 151 151 CD cord-344988-09vpehvf 19 63 , , , cord-344988-09vpehvf 19 64 155 155 CD cord-344988-09vpehvf 19 65 ] ] -RRB- cord-344988-09vpehvf 19 66 . . . cord-344988-09vpehvf 20 1 In in IN cord-344988-09vpehvf 20 2 light light NN cord-344988-09vpehvf 20 3 of of IN cord-344988-09vpehvf 20 4 these these DT cord-344988-09vpehvf 20 5 observations observation NNS cord-344988-09vpehvf 20 6 it -PRON- PRP cord-344988-09vpehvf 20 7 is be VBZ cord-344988-09vpehvf 20 8 easy easy JJ cord-344988-09vpehvf 20 9 to to TO cord-344988-09vpehvf 20 10 understand understand VB cord-344988-09vpehvf 20 11 that that IN cord-344988-09vpehvf 20 12 zinc zinc NN cord-344988-09vpehvf 20 13 ions ion NNS cord-344988-09vpehvf 20 14 are be VBP cord-344988-09vpehvf 20 15 crucial crucial JJ cord-344988-09vpehvf 20 16 for for IN cord-344988-09vpehvf 20 17 multiple multiple JJ cord-344988-09vpehvf 20 18 aspects aspect NNS cord-344988-09vpehvf 20 19 of of IN cord-344988-09vpehvf 20 20 the the DT cord-344988-09vpehvf 20 21 immune immune JJ cord-344988-09vpehvf 20 22 system system NN cord-344988-09vpehvf 20 23 , , , cord-344988-09vpehvf 20 24 including include VBG cord-344988-09vpehvf 20 25 the the DT cord-344988-09vpehvf 20 26 normal normal JJ cord-344988-09vpehvf 20 27 development development NN cord-344988-09vpehvf 20 28 , , , cord-344988-09vpehvf 20 29 differentiation differentiation NN cord-344988-09vpehvf 20 30 , , , cord-344988-09vpehvf 20 31 and and CC cord-344988-09vpehvf 20 32 function function NN cord-344988-09vpehvf 20 33 of of IN cord-344988-09vpehvf 20 34 cells cell NNS cord-344988-09vpehvf 20 35 belonging belong VBG cord-344988-09vpehvf 20 36 to to IN cord-344988-09vpehvf 20 37 both both DT cord-344988-09vpehvf 20 38 innate innate JJ cord-344988-09vpehvf 20 39 and and CC cord-344988-09vpehvf 20 40 acquired acquire VBN cord-344988-09vpehvf 20 41 immunity immunity NN cord-344988-09vpehvf 20 42 [ [ -LRB- cord-344988-09vpehvf 20 43 130 130 CD cord-344988-09vpehvf 20 44 , , , cord-344988-09vpehvf 20 45 170 170 CD cord-344988-09vpehvf 20 46 ] ] -RRB- cord-344988-09vpehvf 20 47 . . . cord-344988-09vpehvf 21 1 Among among IN cord-344988-09vpehvf 21 2 the the DT cord-344988-09vpehvf 21 3 immune immune JJ cord-344988-09vpehvf 21 4 cells cell NNS cord-344988-09vpehvf 21 5 that that WDT cord-344988-09vpehvf 21 6 are be VBP cord-344988-09vpehvf 21 7 affected affect VBN cord-344988-09vpehvf 21 8 by by IN cord-344988-09vpehvf 21 9 zinc zinc NN cord-344988-09vpehvf 21 10 deficiency deficiency NN cord-344988-09vpehvf 21 11 , , , cord-344988-09vpehvf 21 12 T t NN cord-344988-09vpehvf 21 13 lymphocytes lymphocyte NNS cord-344988-09vpehvf 21 14 seem seem VBP cord-344988-09vpehvf 21 15 to to TO cord-344988-09vpehvf 21 16 have have VB cord-344988-09vpehvf 21 17 the the DT cord-344988-09vpehvf 21 18 highest high JJS cord-344988-09vpehvf 21 19 susceptibility susceptibility NN cord-344988-09vpehvf 21 20 [ [ -LRB- cord-344988-09vpehvf 21 21 46 46 CD cord-344988-09vpehvf 21 22 ] ] -RRB- cord-344988-09vpehvf 21 23 and and CC cord-344988-09vpehvf 21 24 are be VBP cord-344988-09vpehvf 21 25 influenced influence VBN cord-344988-09vpehvf 21 26 on on IN cord-344988-09vpehvf 21 27 several several JJ cord-344988-09vpehvf 21 28 levels level NNS cord-344988-09vpehvf 21 29 ( ( -LRB- cord-344988-09vpehvf 21 30 Fig fig NN cord-344988-09vpehvf 21 31 . . NNP cord-344988-09vpehvf 21 32 1 1 CD cord-344988-09vpehvf 21 33 ) ) -RRB- cord-344988-09vpehvf 21 34 . . . cord-344988-09vpehvf 22 1 Zinc zinc NN cord-344988-09vpehvf 22 2 deficiency deficiency NN cord-344988-09vpehvf 22 3 reduces reduce VBZ cord-344988-09vpehvf 22 4 the the DT cord-344988-09vpehvf 22 5 number number NN cord-344988-09vpehvf 22 6 of of IN cord-344988-09vpehvf 22 7 peripheral peripheral JJ cord-344988-09vpehvf 22 8 and and CC cord-344988-09vpehvf 22 9 thymic thymic JJ cord-344988-09vpehvf 22 10 T t NN cord-344988-09vpehvf 22 11 cells cell NNS cord-344988-09vpehvf 22 12 , , , cord-344988-09vpehvf 22 13 their -PRON- PRP$ cord-344988-09vpehvf 22 14 proliferation proliferation NN cord-344988-09vpehvf 22 15 in in IN cord-344988-09vpehvf 22 16 response response NN cord-344988-09vpehvf 22 17 to to IN cord-344988-09vpehvf 22 18 phytohemagglutinin phytohemagglutinin NN cord-344988-09vpehvf 22 19 , , , cord-344988-09vpehvf 22 20 and and CC cord-344988-09vpehvf 22 21 the the DT cord-344988-09vpehvf 22 22 functions function NNS cord-344988-09vpehvf 22 23 of of IN cord-344988-09vpehvf 22 24 T T NNP cord-344988-09vpehvf 22 25 helper helper NN cord-344988-09vpehvf 22 26 ( ( -LRB- cord-344988-09vpehvf 22 27 TH TH NNP cord-344988-09vpehvf 22 28 ) ) -RRB- cord-344988-09vpehvf 22 29 and and CC cord-344988-09vpehvf 22 30 cytotoxic cytotoxic JJ cord-344988-09vpehvf 22 31 T t NN cord-344988-09vpehvf 22 32 cells cell NNS cord-344988-09vpehvf 22 33 , , , cord-344988-09vpehvf 22 34 but but CC cord-344988-09vpehvf 22 35 also also RB cord-344988-09vpehvf 22 36 acts act VBZ cord-344988-09vpehvf 22 37 indirectly indirectly RB cord-344988-09vpehvf 22 38 by by IN cord-344988-09vpehvf 22 39 reducing reduce VBG cord-344988-09vpehvf 22 40 the the DT cord-344988-09vpehvf 22 41 levels level NNS cord-344988-09vpehvf 22 42 of of IN cord-344988-09vpehvf 22 43 active active JJ cord-344988-09vpehvf 22 44 serum serum NN cord-344988-09vpehvf 22 45 thymulin thymulin NN cord-344988-09vpehvf 22 46 . . . cord-344988-09vpehvf 23 1 On on IN cord-344988-09vpehvf 23 2 the the DT cord-344988-09vpehvf 23 3 molecular molecular JJ cord-344988-09vpehvf 23 4 level level NN cord-344988-09vpehvf 23 5 , , , cord-344988-09vpehvf 23 6 zinc zinc NN cord-344988-09vpehvf 23 7 stimulates stimulate VBZ cord-344988-09vpehvf 23 8 the the DT cord-344988-09vpehvf 23 9 autophosphorylation autophosphorylation NN cord-344988-09vpehvf 23 10 of of IN cord-344988-09vpehvf 23 11 the the DT cord-344988-09vpehvf 23 12 protein protein NN cord-344988-09vpehvf 23 13 tyrosine tyrosine NN cord-344988-09vpehvf 23 14 kinase kinase VBZ cord-344988-09vpehvf 23 15 Lck Lck NNP cord-344988-09vpehvf 23 16 by by IN cord-344988-09vpehvf 23 17 non non JJ cord-344988-09vpehvf 23 18 - - JJ cord-344988-09vpehvf 23 19 covalent covalent JJ cord-344988-09vpehvf 23 20 interaction interaction NN cord-344988-09vpehvf 23 21 with with IN cord-344988-09vpehvf 23 22 the the DT cord-344988-09vpehvf 23 23 cytoplasmic cytoplasmic JJ cord-344988-09vpehvf 23 24 tails tail NNS cord-344988-09vpehvf 23 25 of of IN cord-344988-09vpehvf 23 26 CD4 CD4 NNP cord-344988-09vpehvf 23 27 and and CC cord-344988-09vpehvf 23 28 CD8 CD8 NNP cord-344988-09vpehvf 23 29 , , , cord-344988-09vpehvf 23 30 leading lead VBG cord-344988-09vpehvf 23 31 to to IN cord-344988-09vpehvf 23 32 T T NNP cord-344988-09vpehvf 23 33 cell cell NN cord-344988-09vpehvf 23 34 activation activation NN cord-344988-09vpehvf 23 35 [ [ -LRB- cord-344988-09vpehvf 23 36 110 110 CD cord-344988-09vpehvf 23 37 , , , cord-344988-09vpehvf 23 38 137 137 CD cord-344988-09vpehvf 23 39 , , , cord-344988-09vpehvf 23 40 157 157 CD cord-344988-09vpehvf 23 41 ] ] -RRB- cord-344988-09vpehvf 23 42 . . . cord-344988-09vpehvf 24 1 As as IN cord-344988-09vpehvf 24 2 one one CD cord-344988-09vpehvf 24 3 result result NN cord-344988-09vpehvf 24 4 , , , cord-344988-09vpehvf 24 5 the the DT cord-344988-09vpehvf 24 6 delayed delay VBN cord-344988-09vpehvf 24 7 - - HYPH cord-344988-09vpehvf 24 8 type type NN cord-344988-09vpehvf 24 9 hypersensitivity hypersensitivity NN cord-344988-09vpehvf 24 10 reaction reaction NN cord-344988-09vpehvf 24 11 is be VBZ cord-344988-09vpehvf 24 12 usually usually RB cord-344988-09vpehvf 24 13 reduced reduce VBN cord-344988-09vpehvf 24 14 in in IN cord-344988-09vpehvf 24 15 zinc zinc NN cord-344988-09vpehvf 24 16 - - HYPH cord-344988-09vpehvf 24 17 deficient deficient JJ cord-344988-09vpehvf 24 18 individuals individual NNS cord-344988-09vpehvf 24 19 . . . cord-344988-09vpehvf 25 1 However however RB cord-344988-09vpehvf 25 2 , , , cord-344988-09vpehvf 25 3 other other JJ cord-344988-09vpehvf 25 4 cells cell NNS cord-344988-09vpehvf 25 5 are be VBP cord-344988-09vpehvf 25 6 also also RB cord-344988-09vpehvf 25 7 affected affect VBN cord-344988-09vpehvf 25 8 , , , cord-344988-09vpehvf 25 9 leading lead VBG cord-344988-09vpehvf 25 10 to to IN cord-344988-09vpehvf 25 11 reduced reduce VBN cord-344988-09vpehvf 25 12 antibody antibody NN cord-344988-09vpehvf 25 13 production production NN cord-344988-09vpehvf 25 14 and and CC cord-344988-09vpehvf 25 15 compromised compromised JJ cord-344988-09vpehvf 25 16 function function NN cord-344988-09vpehvf 25 17 of of IN cord-344988-09vpehvf 25 18 cells cell NNS cord-344988-09vpehvf 25 19 of of IN cord-344988-09vpehvf 25 20 the the DT cord-344988-09vpehvf 25 21 innate innate JJ cord-344988-09vpehvf 25 22 immune immune JJ cord-344988-09vpehvf 25 23 system system NN cord-344988-09vpehvf 25 24 , , , cord-344988-09vpehvf 25 25 such such JJ cord-344988-09vpehvf 25 26 as as IN cord-344988-09vpehvf 25 27 natural natural JJ cord-344988-09vpehvf 25 28 killer killer NN cord-344988-09vpehvf 25 29 cell cell NN cord-344988-09vpehvf 25 30 activity activity NN cord-344988-09vpehvf 25 31 , , , cord-344988-09vpehvf 25 32 cytokine cytokine NN cord-344988-09vpehvf 25 33 production production NN cord-344988-09vpehvf 25 34 by by IN cord-344988-09vpehvf 25 35 monocytes monocyte NNS cord-344988-09vpehvf 25 36 , , , cord-344988-09vpehvf 25 37 and and CC cord-344988-09vpehvf 25 38 the the DT cord-344988-09vpehvf 25 39 chemotaxis chemotaxis NN cord-344988-09vpehvf 25 40 and and CC cord-344988-09vpehvf 25 41 oxidative oxidative JJ cord-344988-09vpehvf 25 42 burst burst NN cord-344988-09vpehvf 25 43 of of IN cord-344988-09vpehvf 25 44 neutrophil neutrophil NN cord-344988-09vpehvf 25 45 granulocytes granulocyte NNS cord-344988-09vpehvf 25 46 [ [ -LRB- cord-344988-09vpehvf 25 47 65 65 CD cord-344988-09vpehvf 25 48 , , , cord-344988-09vpehvf 25 49 129 129 CD cord-344988-09vpehvf 25 50 ] ] -RRB- cord-344988-09vpehvf 25 51 . . . cord-344988-09vpehvf 26 1 Another another DT cord-344988-09vpehvf 26 2 important important JJ cord-344988-09vpehvf 26 3 aspect aspect NN cord-344988-09vpehvf 26 4 is be VBZ cord-344988-09vpehvf 26 5 the the DT cord-344988-09vpehvf 26 6 interaction interaction NN cord-344988-09vpehvf 26 7 between between IN cord-344988-09vpehvf 26 8 inflammation inflammation NN cord-344988-09vpehvf 26 9 and and CC cord-344988-09vpehvf 26 10 zinc zinc NN cord-344988-09vpehvf 26 11 . . . cord-344988-09vpehvf 27 1 Pro pro JJ cord-344988-09vpehvf 27 2 - - JJ cord-344988-09vpehvf 27 3 inflammatory inflammatory JJ cord-344988-09vpehvf 27 4 cytokines cytokine NNS cord-344988-09vpehvf 27 5 have have VBP cord-344988-09vpehvf 27 6 a a DT cord-344988-09vpehvf 27 7 direct direct JJ cord-344988-09vpehvf 27 8 influence influence NN cord-344988-09vpehvf 27 9 on on IN cord-344988-09vpehvf 27 10 zinc zinc NN cord-344988-09vpehvf 27 11 homeostasis homeostasis NN cord-344988-09vpehvf 27 12 . . . cord-344988-09vpehvf 28 1 It -PRON- PRP cord-344988-09vpehvf 28 2 has have VBZ cord-344988-09vpehvf 28 3 been be VBN cord-344988-09vpehvf 28 4 shown show VBN cord-344988-09vpehvf 28 5 that that IN cord-344988-09vpehvf 28 6 IL-6 IL-6 NNP cord-344988-09vpehvf 28 7 induces induce VBZ cord-344988-09vpehvf 28 8 the the DT cord-344988-09vpehvf 28 9 expression expression NN cord-344988-09vpehvf 28 10 of of IN cord-344988-09vpehvf 28 11 the the DT cord-344988-09vpehvf 28 12 zinc zinc NN cord-344988-09vpehvf 28 13 trans trans NNP cord-344988-09vpehvf 28 14 - - NNP cord-344988-09vpehvf 28 15 porter porter NNP cord-344988-09vpehvf 28 16 Zrt Zrt NNP cord-344988-09vpehvf 28 17 - - : cord-344988-09vpehvf 28 18 and and CC cord-344988-09vpehvf 28 19 Irt Irt NNP cord-344988-09vpehvf 28 20 - - HYPH cord-344988-09vpehvf 28 21 like like JJ cord-344988-09vpehvf 28 22 protein protein NN cord-344988-09vpehvf 28 23 ( ( -LRB- cord-344988-09vpehvf 28 24 ZIP zip NN cord-344988-09vpehvf 28 25 ) ) -RRB- cord-344988-09vpehvf 28 26 14 14 CD cord-344988-09vpehvf 28 27 , , , cord-344988-09vpehvf 28 28 thereby thereby RB cord-344988-09vpehvf 28 29 increasing increase VBG cord-344988-09vpehvf 28 30 zinc zinc NN cord-344988-09vpehvf 28 31 uptake uptake NN cord-344988-09vpehvf 28 32 into into IN cord-344988-09vpehvf 28 33 hepatocytes hepatocyte NNS cord-344988-09vpehvf 28 34 [ [ -LRB- cord-344988-09vpehvf 28 35 80 80 CD cord-344988-09vpehvf 28 36 ] ] -RRB- cord-344988-09vpehvf 28 37 . . . cord-344988-09vpehvf 29 1 IL-6 IL-6 NNP cord-344988-09vpehvf 29 2 also also RB cord-344988-09vpehvf 29 3 upregulates upregulate VBZ cord-344988-09vpehvf 29 4 the the DT cord-344988-09vpehvf 29 5 zinc zinc NN cord-344988-09vpehvf 29 6 binding bind VBG cord-344988-09vpehvf 29 7 protein protein NN cord-344988-09vpehvf 29 8 metallothionein metallothionein NNP cord-344988-09vpehvf 29 9 ( ( -LRB- cord-344988-09vpehvf 29 10 MT MT NNP cord-344988-09vpehvf 29 11 ) ) -RRB- cord-344988-09vpehvf 29 12 and and CC cord-344988-09vpehvf 29 13 increases increase VBZ cord-344988-09vpehvf 29 14 cellular cellular JJ cord-344988-09vpehvf 29 15 zinc zinc NN cord-344988-09vpehvf 29 16 in in IN cord-344988-09vpehvf 29 17 hepatocytes hepatocyte NNS cord-344988-09vpehvf 29 18 [ [ -LRB- cord-344988-09vpehvf 29 19 143 143 CD cord-344988-09vpehvf 29 20 ] ] -RRB- cord-344988-09vpehvf 29 21 . . . cord-344988-09vpehvf 30 1 Experiments experiment NNS cord-344988-09vpehvf 30 2 with with IN cord-344988-09vpehvf 30 3 MT MT NNP cord-344988-09vpehvf 30 4 knockout knockout NN cord-344988-09vpehvf 30 5 mice mouse NNS cord-344988-09vpehvf 30 6 confirmed confirm VBD cord-344988-09vpehvf 30 7 that that IN cord-344988-09vpehvf 30 8 during during IN cord-344988-09vpehvf 30 9 endotoxin endotoxin NN cord-344988-09vpehvf 30 10 - - HYPH cord-344988-09vpehvf 30 11 induced induce VBN cord-344988-09vpehvf 30 12 inflammation inflammation NN cord-344988-09vpehvf 30 13 , , , cord-344988-09vpehvf 30 14 MT MT NNP cord-344988-09vpehvf 30 15 is be VBZ cord-344988-09vpehvf 30 16 required require VBN cord-344988-09vpehvf 30 17 for for IN cord-344988-09vpehvf 30 18 zinc zinc NN cord-344988-09vpehvf 30 19 sequestration sequestration NN cord-344988-09vpehvf 30 20 in in IN cord-344988-09vpehvf 30 21 the the DT cord-344988-09vpehvf 30 22 liver liver NN cord-344988-09vpehvf 30 23 , , , cord-344988-09vpehvf 30 24 leading lead VBG cord-344988-09vpehvf 30 25 to to IN cord-344988-09vpehvf 30 26 a a DT cord-344988-09vpehvf 30 27 significant significant JJ cord-344988-09vpehvf 30 28 reduction reduction NN cord-344988-09vpehvf 30 29 in in IN cord-344988-09vpehvf 30 30 plasma plasma NN cord-344988-09vpehvf 30 31 zinc zinc NN cord-344988-09vpehvf 30 32 levels level NNS cord-344988-09vpehvf 30 33 [ [ -LRB- cord-344988-09vpehvf 30 34 113 113 CD cord-344988-09vpehvf 30 35 ] ] -RRB- cord-344988-09vpehvf 30 36 . . . cord-344988-09vpehvf 31 1 Hence hence RB cord-344988-09vpehvf 31 2 , , , cord-344988-09vpehvf 31 3 during during IN cord-344988-09vpehvf 31 4 the the DT cord-344988-09vpehvf 31 5 acute acute JJ cord-344988-09vpehvf 31 6 - - HYPH cord-344988-09vpehvf 31 7 phase phase NN cord-344988-09vpehvf 31 8 response response NN cord-344988-09vpehvf 31 9 , , , cord-344988-09vpehvf 31 10 hypozincemia hypozincemia NN cord-344988-09vpehvf 31 11 is be VBZ cord-344988-09vpehvf 31 12 caused cause VBN cord-344988-09vpehvf 31 13 by by IN cord-344988-09vpehvf 31 14 ZIP zip NN cord-344988-09vpehvf 31 15 - - HYPH cord-344988-09vpehvf 31 16 mediated mediate VBN cord-344988-09vpehvf 31 17 translocation translocation NN cord-344988-09vpehvf 31 18 of of IN cord-344988-09vpehvf 31 19 zinc zinc NN cord-344988-09vpehvf 31 20 into into IN cord-344988-09vpehvf 31 21 the the DT cord-344988-09vpehvf 31 22 liver liver NN cord-344988-09vpehvf 31 23 and and CC cord-344988-09vpehvf 31 24 sequestration sequestration NN cord-344988-09vpehvf 31 25 bound bind VBN cord-344988-09vpehvf 31 26 to to IN cord-344988-09vpehvf 31 27 MT MT NNP cord-344988-09vpehvf 31 28 ( ( -LRB- cord-344988-09vpehvf 31 29 Fig Fig NNP cord-344988-09vpehvf 31 30 . . NNP cord-344988-09vpehvf 31 31 2 2 CD cord-344988-09vpehvf 31 32 ) ) -RRB- cord-344988-09vpehvf 31 33 . . . cord-344988-09vpehvf 32 1 Conversely conversely RB cord-344988-09vpehvf 32 2 , , , cord-344988-09vpehvf 32 3 zinc zinc NN cord-344988-09vpehvf 32 4 affects affect VBZ cord-344988-09vpehvf 32 5 several several JJ cord-344988-09vpehvf 32 6 aspects aspect NNS cord-344988-09vpehvf 32 7 of of IN cord-344988-09vpehvf 32 8 monocyte monocyte NNP cord-344988-09vpehvf 32 9 signal signal NN cord-344988-09vpehvf 32 10 transduction transduction NN cord-344988-09vpehvf 32 11 and and CC cord-344988-09vpehvf 32 12 the the DT cord-344988-09vpehvf 32 13 secretion secretion NN cord-344988-09vpehvf 32 14 of of IN cord-344988-09vpehvf 32 15 pro pro JJ cord-344988-09vpehvf 32 16 - - JJ cord-344988-09vpehvf 32 17 inflammatory inflammatory JJ cord-344988-09vpehvf 32 18 cytokines cytokine NNS cord-344988-09vpehvf 32 19 by by IN cord-344988-09vpehvf 32 20 these these DT cord-344988-09vpehvf 32 21 cells cell NNS cord-344988-09vpehvf 32 22 [ [ -LRB- cord-344988-09vpehvf 32 23 58 58 CD cord-344988-09vpehvf 32 24 ] ] -RRB- cord-344988-09vpehvf 32 25 , , , cord-344988-09vpehvf 32 26 and and CC cord-344988-09vpehvf 32 27 zinc zinc NN cord-344988-09vpehvf 32 28 supplementation supplementation NN cord-344988-09vpehvf 32 29 has have VBZ cord-344988-09vpehvf 32 30 been be VBN cord-344988-09vpehvf 32 31 shown show VBN cord-344988-09vpehvf 32 32 to to TO cord-344988-09vpehvf 32 33 reduce reduce VB cord-344988-09vpehvf 32 34 the the DT cord-344988-09vpehvf 32 35 production production NN cord-344988-09vpehvf 32 36 of of IN cord-344988-09vpehvf 32 37 tumor tumor NN cord-344988-09vpehvf 32 38 necrosis necrosis NN cord-344988-09vpehvf 32 39 factor factor NN cord-344988-09vpehvf 32 40 ( ( -LRB- cord-344988-09vpehvf 32 41 TNF)-α tnf)-α NN cord-344988-09vpehvf 32 42 and and CC cord-344988-09vpehvf 32 43 interleukin interleukin NN cord-344988-09vpehvf 32 44 ( ( -LRB- cord-344988-09vpehvf 32 45 IL)-1β IL)-1β NNP cord-344988-09vpehvf 32 46 in in IN cord-344988-09vpehvf 32 47 healthy healthy JJ cord-344988-09vpehvf 32 48 human human JJ cord-344988-09vpehvf 32 49 subjects subject NNS cord-344988-09vpehvf 32 50 [ [ -LRB- cord-344988-09vpehvf 32 51 118 118 CD cord-344988-09vpehvf 32 52 ] ] -RRB- cord-344988-09vpehvf 32 53 . . . cord-344988-09vpehvf 33 1 The the DT cord-344988-09vpehvf 33 2 clinical clinical JJ cord-344988-09vpehvf 33 3 manifestations manifestation NNS cord-344988-09vpehvf 33 4 associated associate VBN cord-344988-09vpehvf 33 5 with with IN cord-344988-09vpehvf 33 6 zinc zinc NN cord-344988-09vpehvf 33 7 deficiency deficiency NN cord-344988-09vpehvf 33 8 comprise comprise VBP cord-344988-09vpehvf 33 9 growth growth NN cord-344988-09vpehvf 33 10 retardation retardation NN cord-344988-09vpehvf 33 11 , , , cord-344988-09vpehvf 33 12 thymic thymic JJ cord-344988-09vpehvf 33 13 atrophy atrophy NN cord-344988-09vpehvf 33 14 , , , cord-344988-09vpehvf 33 15 hypogonadism hypogonadism NN cord-344988-09vpehvf 33 16 , , , cord-344988-09vpehvf 33 17 infertility infertility NN cord-344988-09vpehvf 33 18 , , , cord-344988-09vpehvf 33 19 dermatitis dermatitis NN cord-344988-09vpehvf 33 20 , , , cord-344988-09vpehvf 33 21 delayed delay VBN cord-344988-09vpehvf 33 22 wound wound NN cord-344988-09vpehvf 33 23 healing healing NN cord-344988-09vpehvf 33 24 , , , cord-344988-09vpehvf 33 25 alopecia alopecia NN cord-344988-09vpehvf 33 26 , , , cord-344988-09vpehvf 33 27 poor poor JJ cord-344988-09vpehvf 33 28 pregnancy pregnancy NN cord-344988-09vpehvf 33 29 outcomes outcome NNS cord-344988-09vpehvf 33 30 , , , cord-344988-09vpehvf 33 31 teratology teratology NN cord-344988-09vpehvf 33 32 , , , cord-344988-09vpehvf 33 33 anorexia anorexia NN cord-344988-09vpehvf 33 34 , , , cord-344988-09vpehvf 33 35 diarrhea diarrhea NN cord-344988-09vpehvf 33 36 , , , cord-344988-09vpehvf 33 37 and and CC cord-344988-09vpehvf 33 38 increased increase VBN cord-344988-09vpehvf 33 39 susceptibility susceptibility NN cord-344988-09vpehvf 33 40 to to IN cord-344988-09vpehvf 33 41 infectious infectious JJ cord-344988-09vpehvf 33 42 diseases disease NNS cord-344988-09vpehvf 33 43 caused cause VBN cord-344988-09vpehvf 33 44 by by IN cord-344988-09vpehvf 33 45 bacterial bacterial JJ cord-344988-09vpehvf 33 46 , , , cord-344988-09vpehvf 33 47 viral viral JJ cord-344988-09vpehvf 33 48 , , , cord-344988-09vpehvf 33 49 and and CC cord-344988-09vpehvf 33 50 fungal fungal JJ cord-344988-09vpehvf 33 51 pathogens pathogen NNS cord-344988-09vpehvf 33 52 [ [ -LRB- cord-344988-09vpehvf 33 53 88 88 CD cord-344988-09vpehvf 33 54 , , , cord-344988-09vpehvf 33 55 116 116 CD cord-344988-09vpehvf 33 56 , , , cord-344988-09vpehvf 33 57 138 138 CD cord-344988-09vpehvf 33 58 ] ] -RRB- cord-344988-09vpehvf 33 59 . . . cord-344988-09vpehvf 34 1 Those those DT cord-344988-09vpehvf 34 2 symptoms symptom NNS cord-344988-09vpehvf 34 3 are be VBP cord-344988-09vpehvf 34 4 hallmarks hallmark NNS cord-344988-09vpehvf 34 5 of of IN cord-344988-09vpehvf 34 6 the the DT cord-344988-09vpehvf 34 7 autosomal autosomal JJ cord-344988-09vpehvf 34 8 recessive recessive JJ cord-344988-09vpehvf 34 9 inheritable inheritable JJ cord-344988-09vpehvf 34 10 disease disease NN cord-344988-09vpehvf 34 11 acrodermatitis acrodermatitis NNP cord-344988-09vpehvf 34 12 enteropathica enteropathica NNP cord-344988-09vpehvf 34 13 . . . cord-344988-09vpehvf 35 1 It -PRON- PRP cord-344988-09vpehvf 35 2 is be VBZ cord-344988-09vpehvf 35 3 characterized characterize VBN cord-344988-09vpehvf 35 4 by by IN cord-344988-09vpehvf 35 5 low low JJ cord-344988-09vpehvf 35 6 serum serum NN cord-344988-09vpehvf 35 7 zinc zinc NN cord-344988-09vpehvf 35 8 levels level NNS cord-344988-09vpehvf 35 9 [ [ -LRB- cord-344988-09vpehvf 35 10 97 97 CD cord-344988-09vpehvf 35 11 ] ] -RRB- cord-344988-09vpehvf 35 12 . . . cord-344988-09vpehvf 36 1 These these DT cord-344988-09vpehvf 36 2 result result VBP cord-344988-09vpehvf 36 3 from from IN cord-344988-09vpehvf 36 4 reduced reduce VBN cord-344988-09vpehvf 36 5 enteral enteral NN cord-344988-09vpehvf 36 6 zinc zinc NN cord-344988-09vpehvf 36 7 absorption absorption NN cord-344988-09vpehvf 36 8 , , , cord-344988-09vpehvf 36 9 which which WDT cord-344988-09vpehvf 36 10 is be VBZ cord-344988-09vpehvf 36 11 based base VBN cord-344988-09vpehvf 36 12 on on IN cord-344988-09vpehvf 36 13 a a DT cord-344988-09vpehvf 36 14 mutation mutation NN cord-344988-09vpehvf 36 15 in in IN cord-344988-09vpehvf 36 16 the the DT cord-344988-09vpehvf 36 17 SLC39A4 SLC39A4 NNP cord-344988-09vpehvf 36 18 gene gene NN cord-344988-09vpehvf 36 19 that that WDT cord-344988-09vpehvf 36 20 encodes encode VBZ cord-344988-09vpehvf 36 21 the the DT cord-344988-09vpehvf 36 22 intestinal intestinal JJ cord-344988-09vpehvf 36 23 zinc zinc NN cord-344988-09vpehvf 36 24 import import NN cord-344988-09vpehvf 36 25 protein protein NN cord-344988-09vpehvf 36 26 hZIP4 hZIP4 NNP cord-344988-09vpehvf 36 27 [ [ -LRB- cord-344988-09vpehvf 36 28 79 79 CD cord-344988-09vpehvf 36 29 , , , cord-344988-09vpehvf 36 30 81 81 CD cord-344988-09vpehvf 36 31 , , , cord-344988-09vpehvf 36 32 167 167 CD cord-344988-09vpehvf 36 33 ] ] -RRB- cord-344988-09vpehvf 36 34 . . . cord-344988-09vpehvf 37 1 Successful successful JJ cord-344988-09vpehvf 37 2 treatment treatment NN cord-344988-09vpehvf 37 3 of of IN cord-344988-09vpehvf 37 4 all all DT cord-344988-09vpehvf 37 5 symptoms symptom NNS cord-344988-09vpehvf 37 6 was be VBD cord-344988-09vpehvf 37 7 achieved achieve VBN cord-344988-09vpehvf 37 8 by by IN cord-344988-09vpehvf 37 9 oral oral JJ cord-344988-09vpehvf 37 10 zinc zinc NN cord-344988-09vpehvf 37 11 supplementation supplementation NN cord-344988-09vpehvf 37 12 [ [ -LRB- cord-344988-09vpehvf 37 13 48 48 CD cord-344988-09vpehvf 37 14 , , , cord-344988-09vpehvf 37 15 100 100 CD cord-344988-09vpehvf 37 16 ] ] -RRB- cord-344988-09vpehvf 37 17 , , , cord-344988-09vpehvf 37 18 which which WDT cord-344988-09vpehvf 37 19 is be VBZ cord-344988-09vpehvf 37 20 still still RB cord-344988-09vpehvf 37 21 the the DT cord-344988-09vpehvf 37 22 standard standard JJ cord-344988-09vpehvf 37 23 therapy therapy NN cord-344988-09vpehvf 37 24 for for IN cord-344988-09vpehvf 37 25 acrodermatitis acrodermatitis NNP cord-344988-09vpehvf 37 26 enteropathica enteropathica NNP cord-344988-09vpehvf 37 27 . . . cord-344988-09vpehvf 38 1 In in IN cord-344988-09vpehvf 38 2 addition addition NN cord-344988-09vpehvf 38 3 to to IN cord-344988-09vpehvf 38 4 the the DT cord-344988-09vpehvf 38 5 impressive impressive JJ cord-344988-09vpehvf 38 6 effects effect NNS cord-344988-09vpehvf 38 7 on on IN cord-344988-09vpehvf 38 8 acrodermatitis acrodermatitis NNP cord-344988-09vpehvf 38 9 enteropathica enteropathica NNP cord-344988-09vpehvf 38 10 , , , cord-344988-09vpehvf 38 11 which which WDT cord-344988-09vpehvf 38 12 demonstrate demonstrate VBP cord-344988-09vpehvf 38 13 the the DT cord-344988-09vpehvf 38 14 physiological physiological JJ cord-344988-09vpehvf 38 15 importance importance NN cord-344988-09vpehvf 38 16 of of IN cord-344988-09vpehvf 38 17 zinc zinc NN cord-344988-09vpehvf 38 18 , , , cord-344988-09vpehvf 38 19 many many JJ cord-344988-09vpehvf 38 20 studies study NNS cord-344988-09vpehvf 38 21 have have VBP cord-344988-09vpehvf 38 22 been be VBN cord-344988-09vpehvf 38 23 performed perform VBN cord-344988-09vpehvf 38 24 investigating investigate VBG cord-344988-09vpehvf 38 25 the the DT cord-344988-09vpehvf 38 26 effects effect NNS cord-344988-09vpehvf 38 27 of of IN cord-344988-09vpehvf 38 28 zinc zinc NN cord-344988-09vpehvf 38 29 supplementation supplementation NN cord-344988-09vpehvf 38 30 on on IN cord-344988-09vpehvf 38 31 other other JJ cord-344988-09vpehvf 38 32 diseases disease NNS cord-344988-09vpehvf 38 33 . . . cord-344988-09vpehvf 39 1 These these DT cord-344988-09vpehvf 39 2 studies study NNS cord-344988-09vpehvf 39 3 often often RB cord-344988-09vpehvf 39 4 gave give VBD cord-344988-09vpehvf 39 5 highly highly RB cord-344988-09vpehvf 39 6 contradictory contradictory JJ cord-344988-09vpehvf 39 7 results result NNS cord-344988-09vpehvf 39 8 . . . cord-344988-09vpehvf 40 1 Resolving resolve VBG cord-344988-09vpehvf 40 2 these these DT cord-344988-09vpehvf 40 3 discrepancies discrepancy NNS cord-344988-09vpehvf 40 4 is be VBZ cord-344988-09vpehvf 40 5 difficult difficult JJ cord-344988-09vpehvf 40 6 . . . cord-344988-09vpehvf 41 1 A a DT cord-344988-09vpehvf 41 2 major major JJ cord-344988-09vpehvf 41 3 problem problem NN cord-344988-09vpehvf 41 4 is be VBZ cord-344988-09vpehvf 41 5 the the DT cord-344988-09vpehvf 41 6 different different JJ cord-344988-09vpehvf 41 7 amounts amount NNS cord-344988-09vpehvf 41 8 of of IN cord-344988-09vpehvf 41 9 elemental elemental JJ cord-344988-09vpehvf 41 10 zinc zinc NN cord-344988-09vpehvf 41 11 that that WDT cord-344988-09vpehvf 41 12 were be VBD cord-344988-09vpehvf 41 13 administered administer VBN cord-344988-09vpehvf 41 14 , , , cord-344988-09vpehvf 41 15 which which WDT cord-344988-09vpehvf 41 16 sometimes sometimes RB cord-344988-09vpehvf 41 17 differed differ VBD cord-344988-09vpehvf 41 18 by by IN cord-344988-09vpehvf 41 19 more more JJR cord-344988-09vpehvf 41 20 than than IN cord-344988-09vpehvf 41 21 one one CD cord-344988-09vpehvf 41 22 order order NN cord-344988-09vpehvf 41 23 of of IN cord-344988-09vpehvf 41 24 magnitude magnitude NN cord-344988-09vpehvf 41 25 . . . cord-344988-09vpehvf 42 1 Matters matter NNS cord-344988-09vpehvf 42 2 are be VBP cord-344988-09vpehvf 42 3 complicated complicate VBN cord-344988-09vpehvf 42 4 even even RB cord-344988-09vpehvf 42 5 further further RB cord-344988-09vpehvf 42 6 by by IN cord-344988-09vpehvf 42 7 the the DT cord-344988-09vpehvf 42 8 fact fact NN cord-344988-09vpehvf 42 9 that that IN cord-344988-09vpehvf 42 10 the the DT cord-344988-09vpehvf 42 11 metal metal NN cord-344988-09vpehvf 42 12 content content NN cord-344988-09vpehvf 42 13 varies vary VBZ cord-344988-09vpehvf 42 14 significantly significantly RB cord-344988-09vpehvf 42 15 between between IN cord-344988-09vpehvf 42 16 different different JJ cord-344988-09vpehvf 42 17 zinc zinc NN cord-344988-09vpehvf 42 18 salts salt NNS cord-344988-09vpehvf 42 19 , , , cord-344988-09vpehvf 42 20 and and CC cord-344988-09vpehvf 42 21 several several JJ cord-344988-09vpehvf 42 22 zinc zinc NN cord-344988-09vpehvf 42 23 supplements supplement NNS cord-344988-09vpehvf 42 24 even even RB cord-344988-09vpehvf 42 25 exist exist VBP cord-344988-09vpehvf 42 26 in in IN cord-344988-09vpehvf 42 27 different different JJ cord-344988-09vpehvf 42 28 salt salt NN cord-344988-09vpehvf 42 29 forms form NNS cord-344988-09vpehvf 42 30 ( ( -LRB- cord-344988-09vpehvf 42 31 Table table NN cord-344988-09vpehvf 42 32 1 1 CD cord-344988-09vpehvf 42 33 ) ) -RRB- cord-344988-09vpehvf 42 34 . . . cord-344988-09vpehvf 43 1 If if IN cord-344988-09vpehvf 43 2 this this DT cord-344988-09vpehvf 43 3 form form NN cord-344988-09vpehvf 43 4 is be VBZ cord-344988-09vpehvf 43 5 not not RB cord-344988-09vpehvf 43 6 specified specify VBN cord-344988-09vpehvf 43 7 , , , cord-344988-09vpehvf 43 8 the the DT cord-344988-09vpehvf 43 9 amount amount NN cord-344988-09vpehvf 43 10 of of IN cord-344988-09vpehvf 43 11 elemental elemental JJ cord-344988-09vpehvf 43 12 zinc zinc NN cord-344988-09vpehvf 43 13 that that WDT cord-344988-09vpehvf 43 14 has have VBZ cord-344988-09vpehvf 43 15 been be VBN cord-344988-09vpehvf 43 16 administered administer VBN cord-344988-09vpehvf 43 17 can can MD cord-344988-09vpehvf 43 18 not not RB cord-344988-09vpehvf 43 19 be be VB cord-344988-09vpehvf 43 20 calculated calculate VBN cord-344988-09vpehvf 43 21 reliably reliably RB cord-344988-09vpehvf 43 22 . . . cord-344988-09vpehvf 44 1 Furthermore furthermore RB cord-344988-09vpehvf 44 2 , , , cord-344988-09vpehvf 44 3 even even RB cord-344988-09vpehvf 44 4 if if IN cord-344988-09vpehvf 44 5 the the DT cord-344988-09vpehvf 44 6 same same JJ cord-344988-09vpehvf 44 7 supplement supplement NN cord-344988-09vpehvf 44 8 is be VBZ cord-344988-09vpehvf 44 9 used use VBN cord-344988-09vpehvf 44 10 in in IN cord-344988-09vpehvf 44 11 various various JJ cord-344988-09vpehvf 44 12 studies study NNS cord-344988-09vpehvf 44 13 , , , cord-344988-09vpehvf 44 14 the the DT cord-344988-09vpehvf 44 15 amount amount NN cord-344988-09vpehvf 44 16 of of IN cord-344988-09vpehvf 44 17 calculated calculated JJ cord-344988-09vpehvf 44 18 elemental elemental JJ cord-344988-09vpehvf 44 19 zinc zinc NN cord-344988-09vpehvf 44 20 diverges diverge VBZ cord-344988-09vpehvf 44 21 between between IN cord-344988-09vpehvf 44 22 different different JJ cord-344988-09vpehvf 44 23 research research NN cord-344988-09vpehvf 44 24 groups group NNS cord-344988-09vpehvf 44 25 . . . cord-344988-09vpehvf 45 1 Other other JJ cord-344988-09vpehvf 45 2 studies study NNS cord-344988-09vpehvf 45 3 do do VBP cord-344988-09vpehvf 45 4 not not RB cord-344988-09vpehvf 45 5 report report VB cord-344988-09vpehvf 45 6 the the DT cord-344988-09vpehvf 45 7 zinc zinc NN cord-344988-09vpehvf 45 8 status status NN cord-344988-09vpehvf 45 9 of of IN cord-344988-09vpehvf 45 10 the the DT cord-344988-09vpehvf 45 11 patients patient NNS cord-344988-09vpehvf 45 12 , , , cord-344988-09vpehvf 45 13 and and CC cord-344988-09vpehvf 45 14 zinc zinc NN cord-344988-09vpehvf 45 15 - - HYPH cord-344988-09vpehvf 45 16 deficient deficient JJ cord-344988-09vpehvf 45 17 subjects subject NNS cord-344988-09vpehvf 45 18 will will MD cord-344988-09vpehvf 45 19 react react VB cord-344988-09vpehvf 45 20 differently differently RB cord-344988-09vpehvf 45 21 to to IN cord-344988-09vpehvf 45 22 zinc zinc NN cord-344988-09vpehvf 45 23 treatment treatment NN cord-344988-09vpehvf 45 24 than than IN cord-344988-09vpehvf 45 25 zinc zinc NN cord-344988-09vpehvf 45 26 - - HYPH cord-344988-09vpehvf 45 27 sufficient sufficient JJ cord-344988-09vpehvf 45 28 ones one NNS cord-344988-09vpehvf 45 29 . . . cord-344988-09vpehvf 46 1 Even even RB cord-344988-09vpehvf 46 2 when when WRB cord-344988-09vpehvf 46 3 data datum NNS cord-344988-09vpehvf 46 4 regarding regard VBG cord-344988-09vpehvf 46 5 the the DT cord-344988-09vpehvf 46 6 patients patient NNS cord-344988-09vpehvf 46 7 zinc zinc NN cord-344988-09vpehvf 46 8 status status NN cord-344988-09vpehvf 46 9 are be VBP cord-344988-09vpehvf 46 10 provided provide VBN cord-344988-09vpehvf 46 11 , , , cord-344988-09vpehvf 46 12 the the DT cord-344988-09vpehvf 46 13 parameters parameter NNS cord-344988-09vpehvf 46 14 measured measure VBN cord-344988-09vpehvf 46 15 in in IN cord-344988-09vpehvf 46 16 most most JJS cord-344988-09vpehvf 46 17 studies study NNS cord-344988-09vpehvf 46 18 are be VBP cord-344988-09vpehvf 46 19 total total JJ cord-344988-09vpehvf 46 20 serum serum NN cord-344988-09vpehvf 46 21 or or CC cord-344988-09vpehvf 46 22 plasma plasma NN cord-344988-09vpehvf 46 23 zinc zinc NN cord-344988-09vpehvf 46 24 . . . cord-344988-09vpehvf 47 1 The the DT cord-344988-09vpehvf 47 2 significance significance NN cord-344988-09vpehvf 47 3 of of IN cord-344988-09vpehvf 47 4 these these DT cord-344988-09vpehvf 47 5 values value NNS cord-344988-09vpehvf 47 6 is be VBZ cord-344988-09vpehvf 47 7 questionable questionable JJ cord-344988-09vpehvf 47 8 . . . cord-344988-09vpehvf 48 1 While while IN cord-344988-09vpehvf 48 2 they -PRON- PRP cord-344988-09vpehvf 48 3 are be VBP cord-344988-09vpehvf 48 4 well well RB cord-344988-09vpehvf 48 5 suited suited JJ cord-344988-09vpehvf 48 6 to to TO cord-344988-09vpehvf 48 7 detect detect VB cord-344988-09vpehvf 48 8 severe severe JJ cord-344988-09vpehvf 48 9 forms form NNS cord-344988-09vpehvf 48 10 of of IN cord-344988-09vpehvf 48 11 zinc zinc NN cord-344988-09vpehvf 48 12 deficiency deficiency NN cord-344988-09vpehvf 48 13 , , , cord-344988-09vpehvf 48 14 they -PRON- PRP cord-344988-09vpehvf 48 15 are be VBP cord-344988-09vpehvf 48 16 not not RB cord-344988-09vpehvf 48 17 adequate adequate JJ cord-344988-09vpehvf 48 18 parameters parameter NNS cord-344988-09vpehvf 48 19 to to TO cord-344988-09vpehvf 48 20 indicate indicate VB cord-344988-09vpehvf 48 21 marginal marginal JJ cord-344988-09vpehvf 48 22 zinc zinc NN cord-344988-09vpehvf 48 23 deficiency deficiency NN cord-344988-09vpehvf 48 24 [ [ -LRB- cord-344988-09vpehvf 48 25 2 2 CD cord-344988-09vpehvf 48 26 , , , cord-344988-09vpehvf 48 27 56 56 CD cord-344988-09vpehvf 48 28 ] ] -RRB- cord-344988-09vpehvf 48 29 . . . cord-344988-09vpehvf 49 1 Another another DT cord-344988-09vpehvf 49 2 important important JJ cord-344988-09vpehvf 49 3 difference difference NN cord-344988-09vpehvf 49 4 between between IN cord-344988-09vpehvf 49 5 studies study NNS cord-344988-09vpehvf 49 6 can can MD cord-344988-09vpehvf 49 7 result result VB cord-344988-09vpehvf 49 8 from from IN cord-344988-09vpehvf 49 9 the the DT cord-344988-09vpehvf 49 10 differential differential JJ cord-344988-09vpehvf 49 11 bioavailability bioavailability NN cord-344988-09vpehvf 49 12 of of IN cord-344988-09vpehvf 49 13 the the DT cord-344988-09vpehvf 49 14 zinc zinc NN cord-344988-09vpehvf 49 15 supplements supplement NNS cord-344988-09vpehvf 49 16 [ [ -LRB- cord-344988-09vpehvf 49 17 94 94 CD cord-344988-09vpehvf 49 18 ] ] -RRB- cord-344988-09vpehvf 49 19 . . . cord-344988-09vpehvf 50 1 Salts salt NNS cord-344988-09vpehvf 50 2 with with IN cord-344988-09vpehvf 50 3 organic organic JJ cord-344988-09vpehvf 50 4 anions anion NNS cord-344988-09vpehvf 50 5 such such JJ cord-344988-09vpehvf 50 6 as as IN cord-344988-09vpehvf 50 7 acetate acetate NN cord-344988-09vpehvf 50 8 , , , cord-344988-09vpehvf 50 9 methionine methionine NN cord-344988-09vpehvf 50 10 , , , cord-344988-09vpehvf 50 11 or or CC cord-344988-09vpehvf 50 12 histidine histidine NN cord-344988-09vpehvf 50 13 generally generally RB cord-344988-09vpehvf 50 14 have have VBP cord-344988-09vpehvf 50 15 a a DT cord-344988-09vpehvf 50 16 higher high JJR cord-344988-09vpehvf 50 17 bioavailability bioavailability NN cord-344988-09vpehvf 50 18 than than IN cord-344988-09vpehvf 50 19 zinc zinc NN cord-344988-09vpehvf 50 20 sulfate sulfate NN cord-344988-09vpehvf 50 21 , , , cord-344988-09vpehvf 50 22 while while IN cord-344988-09vpehvf 50 23 zinc zinc NN cord-344988-09vpehvf 50 24 oxide oxide NN cord-344988-09vpehvf 50 25 is be VBZ cord-344988-09vpehvf 50 26 of of IN cord-344988-09vpehvf 50 27 lower low JJR cord-344988-09vpehvf 50 28 availability availability NN cord-344988-09vpehvf 50 29 . . . cord-344988-09vpehvf 51 1 Furthermore furthermore RB cord-344988-09vpehvf 51 2 , , , cord-344988-09vpehvf 51 3 zinc zinc NN cord-344988-09vpehvf 51 4 uptake uptake NN cord-344988-09vpehvf 51 5 does do VBZ cord-344988-09vpehvf 51 6 not not RB cord-344988-09vpehvf 51 7 only only RB cord-344988-09vpehvf 51 8 vary vary VB cord-344988-09vpehvf 51 9 between between IN cord-344988-09vpehvf 51 10 different different JJ cord-344988-09vpehvf 51 11 salt salt NN cord-344988-09vpehvf 51 12 forms form NNS cord-344988-09vpehvf 51 13 , , , cord-344988-09vpehvf 51 14 but but CC cord-344988-09vpehvf 51 15 also also RB cord-344988-09vpehvf 51 16 depends depend VBZ cord-344988-09vpehvf 51 17 on on IN cord-344988-09vpehvf 51 18 the the DT cord-344988-09vpehvf 51 19 source source NN cord-344988-09vpehvf 51 20 and and CC cord-344988-09vpehvf 51 21 manufacturing manufacturing NN cord-344988-09vpehvf 51 22 process process NN cord-344988-09vpehvf 51 23 of of IN cord-344988-09vpehvf 51 24 the the DT cord-344988-09vpehvf 51 25 supplements supplement NNS cord-344988-09vpehvf 51 26 , , , cord-344988-09vpehvf 51 27 particularly particularly RB cord-344988-09vpehvf 51 28 with with IN cord-344988-09vpehvf 51 29 regard regard NN cord-344988-09vpehvf 51 30 to to IN cord-344988-09vpehvf 51 31 ZnO ZnO NNP cord-344988-09vpehvf 51 32 [ [ -LRB- cord-344988-09vpehvf 51 33 35 35 CD cord-344988-09vpehvf 51 34 ] ] -RRB- cord-344988-09vpehvf 52 1 ( ( -LRB- cord-344988-09vpehvf 52 2 Table table NN cord-344988-09vpehvf 52 3 2 2 CD cord-344988-09vpehvf 52 4 ) ) -RRB- cord-344988-09vpehvf 52 5 . . . cord-344988-09vpehvf 53 1 Inflammation inflammation NN cord-344988-09vpehvf 53 2 and and CC cord-344988-09vpehvf 53 3 zinc zinc NN cord-344988-09vpehvf 53 4 homeostasis homeostasis NN cord-344988-09vpehvf 53 5 . . . cord-344988-09vpehvf 54 1 Pro pro JJ cord-344988-09vpehvf 54 2 - - JJ cord-344988-09vpehvf 54 3 inflammatory inflammatory JJ cord-344988-09vpehvf 54 4 cytokines cytokine NNS cord-344988-09vpehvf 54 5 induce induce VBP cord-344988-09vpehvf 54 6 the the DT cord-344988-09vpehvf 54 7 production production NN cord-344988-09vpehvf 54 8 of of IN cord-344988-09vpehvf 54 9 ZIP14 ZIP14 NNP cord-344988-09vpehvf 54 10 and and CC cord-344988-09vpehvf 54 11 metallothionein metallothionein NNP cord-344988-09vpehvf 54 12 ( ( -LRB- cord-344988-09vpehvf 54 13 MT MT NNP cord-344988-09vpehvf 54 14 ) ) -RRB- cord-344988-09vpehvf 54 15 . . . cord-344988-09vpehvf 55 1 This this DT cord-344988-09vpehvf 55 2 leads lead VBZ cord-344988-09vpehvf 55 3 to to IN cord-344988-09vpehvf 55 4 enhanced enhanced JJ cord-344988-09vpehvf 55 5 zinc zinc NN cord-344988-09vpehvf 55 6 transport transport NN cord-344988-09vpehvf 55 7 via via IN cord-344988-09vpehvf 55 8 ZIP14 zip14 NN cord-344988-09vpehvf 55 9 into into IN cord-344988-09vpehvf 55 10 liver liver NN cord-344988-09vpehvf 55 11 cells cell NNS cord-344988-09vpehvf 55 12 , , , cord-344988-09vpehvf 55 13 where where WRB cord-344988-09vpehvf 55 14 it -PRON- PRP cord-344988-09vpehvf 55 15 is be VBZ cord-344988-09vpehvf 55 16 stored store VBN cord-344988-09vpehvf 55 17 bound bind VBN cord-344988-09vpehvf 55 18 to to IN cord-344988-09vpehvf 55 19 MT MT NNP cord-344988-09vpehvf 55 20 . . . cord-344988-09vpehvf 56 1 As as IN cord-344988-09vpehvf 56 2 a a DT cord-344988-09vpehvf 56 3 consequence consequence NN cord-344988-09vpehvf 56 4 of of IN cord-344988-09vpehvf 56 5 this this DT cord-344988-09vpehvf 56 6 zinc zinc NN cord-344988-09vpehvf 56 7 translocation translocation NN cord-344988-09vpehvf 56 8 from from IN cord-344988-09vpehvf 56 9 plasma plasma NN cord-344988-09vpehvf 56 10 into into IN cord-344988-09vpehvf 56 11 the the DT cord-344988-09vpehvf 56 12 liver liver NN cord-344988-09vpehvf 56 13 , , , cord-344988-09vpehvf 56 14 a a DT cord-344988-09vpehvf 56 15 significant significant JJ cord-344988-09vpehvf 56 16 decrease decrease NN cord-344988-09vpehvf 56 17 in in IN cord-344988-09vpehvf 56 18 plasma plasma NN cord-344988-09vpehvf 56 19 zinc zinc NN cord-344988-09vpehvf 56 20 occurs occur VBZ cord-344988-09vpehvf 56 21 during during IN cord-344988-09vpehvf 56 22 inflammation inflammation NN cord-344988-09vpehvf 56 23 . . . cord-344988-09vpehvf 57 1 On on IN cord-344988-09vpehvf 57 2 the the DT cord-344988-09vpehvf 57 3 other other JJ cord-344988-09vpehvf 57 4 hand hand NN cord-344988-09vpehvf 57 5 , , , cord-344988-09vpehvf 57 6 zinc zinc NN cord-344988-09vpehvf 57 7 affects affect VBZ cord-344988-09vpehvf 57 8 pro pro JJ cord-344988-09vpehvf 57 9 - - JJ cord-344988-09vpehvf 57 10 inflammatory inflammatory JJ cord-344988-09vpehvf 57 11 cytokine cytokine NN cord-344988-09vpehvf 57 12 production production NN cord-344988-09vpehvf 57 13 by by IN cord-344988-09vpehvf 57 14 monocytes monocyte NNS cord-344988-09vpehvf 57 15 ( ( -LRB- cord-344988-09vpehvf 57 16 M M NNP cord-344988-09vpehvf 57 17 ) ) -RRB- cord-344988-09vpehvf 57 18 . . . cord-344988-09vpehvf 58 1 Hence hence RB cord-344988-09vpehvf 58 2 plasma plasma NN cord-344988-09vpehvf 58 3 zinc zinc NN cord-344988-09vpehvf 58 4 levels level NNS cord-344988-09vpehvf 58 5 can can MD cord-344988-09vpehvf 58 6 regulate regulate VB cord-344988-09vpehvf 58 7 cytokine cytokine JJ cord-344988-09vpehvf 58 8 secretion secretion NN cord-344988-09vpehvf 58 9 . . . cord-344988-09vpehvf 59 1 Solid solid JJ cord-344988-09vpehvf 59 2 lines line NNS cord-344988-09vpehvf 59 3 show show VBP cord-344988-09vpehvf 59 4 a a DT cord-344988-09vpehvf 59 5 direct direct JJ cord-344988-09vpehvf 59 6 release release NN cord-344988-09vpehvf 59 7 or or CC cord-344988-09vpehvf 59 8 translocation translocation NN cord-344988-09vpehvf 59 9 of of IN cord-344988-09vpehvf 59 10 a a DT cord-344988-09vpehvf 59 11 substance substance NN cord-344988-09vpehvf 59 12 , , , cord-344988-09vpehvf 59 13 while while IN cord-344988-09vpehvf 59 14 dashed dash VBN cord-344988-09vpehvf 59 15 lines line NNS cord-344988-09vpehvf 59 16 indicate indicate VBP cord-344988-09vpehvf 59 17 a a DT cord-344988-09vpehvf 59 18 modulation modulation NN cord-344988-09vpehvf 59 19 of of IN cord-344988-09vpehvf 59 20 expression expression NN cord-344988-09vpehvf 59 21 . . . cord-344988-09vpehvf 60 1 Concerning concern VBG cord-344988-09vpehvf 60 2 bioavailability bioavailability NN cord-344988-09vpehvf 60 3 , , , cord-344988-09vpehvf 60 4 one one PRP cord-344988-09vpehvf 60 5 has have VBZ cord-344988-09vpehvf 60 6 also also RB cord-344988-09vpehvf 60 7 to to TO cord-344988-09vpehvf 60 8 consider consider VB cord-344988-09vpehvf 60 9 the the DT cord-344988-09vpehvf 60 10 nature nature NN cord-344988-09vpehvf 60 11 of of IN cord-344988-09vpehvf 60 12 the the DT cord-344988-09vpehvf 60 13 diet diet NN cord-344988-09vpehvf 60 14 consumed consume VBN cord-344988-09vpehvf 60 15 by by IN cord-344988-09vpehvf 60 16 the the DT cord-344988-09vpehvf 60 17 subjects subject NNS cord-344988-09vpehvf 60 18 . . . cord-344988-09vpehvf 61 1 The the DT cord-344988-09vpehvf 61 2 uptake uptake NN cord-344988-09vpehvf 61 3 of of IN cord-344988-09vpehvf 61 4 zinc zinc NN cord-344988-09vpehvf 61 5 is be VBZ cord-344988-09vpehvf 61 6 more more RBR cord-344988-09vpehvf 61 7 efficient efficient JJ cord-344988-09vpehvf 61 8 with with IN cord-344988-09vpehvf 61 9 an an DT cord-344988-09vpehvf 61 10 intake intake NN cord-344988-09vpehvf 61 11 of of IN cord-344988-09vpehvf 61 12 animal animal NN cord-344988-09vpehvf 61 13 protein protein NN cord-344988-09vpehvf 61 14 than than IN cord-344988-09vpehvf 61 15 with with IN cord-344988-09vpehvf 61 16 a a DT cord-344988-09vpehvf 61 17 dietary dietary JJ cord-344988-09vpehvf 61 18 intake intake NN cord-344988-09vpehvf 61 19 predominantly predominantly RB cord-344988-09vpehvf 61 20 consisting consist VBG cord-344988-09vpehvf 61 21 of of IN cord-344988-09vpehvf 61 22 cereal cereal NN cord-344988-09vpehvf 61 23 protein protein NN cord-344988-09vpehvf 61 24 . . . cord-344988-09vpehvf 62 1 The the DT cord-344988-09vpehvf 62 2 absorption absorption NN cord-344988-09vpehvf 62 3 of of IN cord-344988-09vpehvf 62 4 zinc zinc NN cord-344988-09vpehvf 62 5 is be VBZ cord-344988-09vpehvf 62 6 negatively negatively RB cord-344988-09vpehvf 62 7 influenced influence VBN cord-344988-09vpehvf 62 8 by by IN cord-344988-09vpehvf 62 9 zinc zinc NN cord-344988-09vpehvf 62 10 - - HYPH cord-344988-09vpehvf 62 11 chelating chelate VBG cord-344988-09vpehvf 62 12 phytates phytate NNS cord-344988-09vpehvf 62 13 and and CC cord-344988-09vpehvf 62 14 phosphates phosphate NNS cord-344988-09vpehvf 62 15 as as RB cord-344988-09vpehvf 62 16 well well RB cord-344988-09vpehvf 62 17 as as IN cord-344988-09vpehvf 62 18 by by IN cord-344988-09vpehvf 62 19 augmented augment VBN cord-344988-09vpehvf 62 20 levels level NNS cord-344988-09vpehvf 62 21 of of IN cord-344988-09vpehvf 62 22 other other JJ cord-344988-09vpehvf 62 23 bivalent bivalent JJ cord-344988-09vpehvf 62 24 cations cation NNS cord-344988-09vpehvf 62 25 , , , cord-344988-09vpehvf 62 26 such such JJ cord-344988-09vpehvf 62 27 as as IN cord-344988-09vpehvf 62 28 Cu Cu NNP cord-344988-09vpehvf 62 29 , , , cord-344988-09vpehvf 62 30 Mg Mg NNP cord-344988-09vpehvf 62 31 , , , cord-344988-09vpehvf 63 1 Ca ca UH cord-344988-09vpehvf 63 2 , , , cord-344988-09vpehvf 63 3 Ni Ni NNP cord-344988-09vpehvf 63 4 , , , cord-344988-09vpehvf 63 5 Cd Cd NNP cord-344988-09vpehvf 63 6 , , , cord-344988-09vpehvf 63 7 and and CC cord-344988-09vpehvf 63 8 Fe Fe NNP cord-344988-09vpehvf 63 9 . . . cord-344988-09vpehvf 64 1 On on IN cord-344988-09vpehvf 64 2 the the DT cord-344988-09vpehvf 64 3 other other JJ cord-344988-09vpehvf 64 4 hand hand NN cord-344988-09vpehvf 64 5 , , , cord-344988-09vpehvf 64 6 it -PRON- PRP cord-344988-09vpehvf 64 7 is be VBZ cord-344988-09vpehvf 64 8 increased increase VBN cord-344988-09vpehvf 64 9 by by IN cord-344988-09vpehvf 64 10 high high JJ cord-344988-09vpehvf 64 11 amounts amount NNS cord-344988-09vpehvf 64 12 of of IN cord-344988-09vpehvf 64 13 proteins protein NNS cord-344988-09vpehvf 64 14 and and CC cord-344988-09vpehvf 64 15 single single JJ cord-344988-09vpehvf 64 16 amino amino NN cord-344988-09vpehvf 64 17 acids acid NNS cord-344988-09vpehvf 64 18 , , , cord-344988-09vpehvf 64 19 in in IN cord-344988-09vpehvf 64 20 particular particular JJ cord-344988-09vpehvf 64 21 histidine histidine NN cord-344988-09vpehvf 64 22 and and CC cord-344988-09vpehvf 64 23 methionine methionine NN cord-344988-09vpehvf 64 24 [ [ -LRB- cord-344988-09vpehvf 64 25 82 82 CD cord-344988-09vpehvf 64 26 , , , cord-344988-09vpehvf 64 27 159 159 CD cord-344988-09vpehvf 64 28 ] ] -RRB- cord-344988-09vpehvf 64 29 . . . cord-344988-09vpehvf 65 1 In in IN cord-344988-09vpehvf 65 2 turn turn NN cord-344988-09vpehvf 65 3 , , , cord-344988-09vpehvf 65 4 high high JJ cord-344988-09vpehvf 65 5 - - HYPH cord-344988-09vpehvf 65 6 dose dose NN cord-344988-09vpehvf 65 7 zinc zinc NN cord-344988-09vpehvf 65 8 supplementation supplementation NN cord-344988-09vpehvf 65 9 can can MD cord-344988-09vpehvf 65 10 also also RB cord-344988-09vpehvf 65 11 interfere interfere VB cord-344988-09vpehvf 65 12 with with IN cord-344988-09vpehvf 65 13 the the DT cord-344988-09vpehvf 65 14 uptake uptake NN cord-344988-09vpehvf 65 15 of of IN cord-344988-09vpehvf 65 16 other other JJ cord-344988-09vpehvf 65 17 nutrients nutrient NNS cord-344988-09vpehvf 65 18 . . . cord-344988-09vpehvf 66 1 This this DT cord-344988-09vpehvf 66 2 has have VBZ cord-344988-09vpehvf 66 3 been be VBN cord-344988-09vpehvf 66 4 documented document VBN cord-344988-09vpehvf 66 5 for for IN cord-344988-09vpehvf 66 6 iron iron NN cord-344988-09vpehvf 66 7 [ [ -LRB- cord-344988-09vpehvf 66 8 105 105 CD cord-344988-09vpehvf 66 9 ] ] -RRB- cord-344988-09vpehvf 66 10 , , , cord-344988-09vpehvf 66 11 and and CC cord-344988-09vpehvf 66 12 in in IN cord-344988-09vpehvf 66 13 particular particular JJ cord-344988-09vpehvf 66 14 for for IN cord-344988-09vpehvf 66 15 copper copper NN cord-344988-09vpehvf 66 16 . . . cord-344988-09vpehvf 67 1 Impaired impair VBN cord-344988-09vpehvf 67 2 copper copper NN cord-344988-09vpehvf 67 3 uptake uptake NN cord-344988-09vpehvf 67 4 by by IN cord-344988-09vpehvf 67 5 excessive excessive JJ cord-344988-09vpehvf 67 6 zinc zinc NN cord-344988-09vpehvf 67 7 supplementation supplementation NN cord-344988-09vpehvf 67 8 induces induce VBZ cord-344988-09vpehvf 67 9 severe severe JJ cord-344988-09vpehvf 67 10 copper copper NN cord-344988-09vpehvf 67 11 deficiency deficiency NN cord-344988-09vpehvf 67 12 , , , cord-344988-09vpehvf 67 13 which which WDT cord-344988-09vpehvf 67 14 can can MD cord-344988-09vpehvf 67 15 lead lead VB cord-344988-09vpehvf 67 16 to to IN cord-344988-09vpehvf 67 17 anemia anemia NN cord-344988-09vpehvf 67 18 and and CC cord-344988-09vpehvf 67 19 neutropenia neutropenia NN cord-344988-09vpehvf 67 20 , , , cord-344988-09vpehvf 67 21 abrogating abrogate VBG cord-344988-09vpehvf 67 22 the the DT cord-344988-09vpehvf 67 23 potential potential JJ cord-344988-09vpehvf 67 24 bene bene JJ cord-344988-09vpehvf 67 25 - - HYPH cord-344988-09vpehvf 67 26 ficial ficial JJ cord-344988-09vpehvf 67 27 effects effect NNS cord-344988-09vpehvf 67 28 of of IN cord-344988-09vpehvf 67 29 zinc zinc NN cord-344988-09vpehvf 67 30 therapy therapy NN cord-344988-09vpehvf 67 31 [ [ -LRB- cord-344988-09vpehvf 67 32 114 114 CD cord-344988-09vpehvf 67 33 , , , cord-344988-09vpehvf 67 34 120 120 CD cord-344988-09vpehvf 67 35 , , , cord-344988-09vpehvf 67 36 139 139 CD cord-344988-09vpehvf 67 37 ] ] -RRB- cord-344988-09vpehvf 67 38 . . . cord-344988-09vpehvf 68 1 Finally finally RB cord-344988-09vpehvf 68 2 , , , cord-344988-09vpehvf 68 3 gastric gastric JJ cord-344988-09vpehvf 68 4 acidity acidity NN cord-344988-09vpehvf 68 5 enhances enhance VBZ cord-344988-09vpehvf 68 6 zinc zinc NN cord-344988-09vpehvf 68 7 absorption absorption NN cord-344988-09vpehvf 68 8 , , , cord-344988-09vpehvf 68 9 especially especially RB cord-344988-09vpehvf 68 10 for for IN cord-344988-09vpehvf 68 11 zinc zinc NN cord-344988-09vpehvf 68 12 oxide oxide NN cord-344988-09vpehvf 68 13 . . . cord-344988-09vpehvf 69 1 This this DT cord-344988-09vpehvf 69 2 can can MD cord-344988-09vpehvf 69 3 be be VB cord-344988-09vpehvf 69 4 a a DT cord-344988-09vpehvf 69 5 particular particular JJ cord-344988-09vpehvf 69 6 problem problem NN cord-344988-09vpehvf 69 7 for for IN cord-344988-09vpehvf 69 8 the the DT cord-344988-09vpehvf 69 9 elderly elderly JJ cord-344988-09vpehvf 69 10 . . . cord-344988-09vpehvf 70 1 They -PRON- PRP cord-344988-09vpehvf 70 2 have have VBP cord-344988-09vpehvf 70 3 a a DT cord-344988-09vpehvf 70 4 high high JJ cord-344988-09vpehvf 70 5 incidence incidence NN cord-344988-09vpehvf 70 6 of of IN cord-344988-09vpehvf 70 7 hypo hypo NN cord-344988-09vpehvf 70 8 - - : cord-344988-09vpehvf 70 9 or or CC cord-344988-09vpehvf 70 10 achlorhydria achlorhydria NNP cord-344988-09vpehvf 70 11 [ [ -LRB- cord-344988-09vpehvf 70 12 61 61 CD cord-344988-09vpehvf 70 13 ] ] -RRB- cord-344988-09vpehvf 70 14 and and CC cord-344988-09vpehvf 70 15 show show VBP cord-344988-09vpehvf 70 16 a a DT cord-344988-09vpehvf 70 17 general general JJ cord-344988-09vpehvf 70 18 tendency tendency NN cord-344988-09vpehvf 70 19 for for IN cord-344988-09vpehvf 70 20 lower low JJR cord-344988-09vpehvf 70 21 zinc zinc NN cord-344988-09vpehvf 70 22 levels level NNS cord-344988-09vpehvf 70 23 , , , cord-344988-09vpehvf 70 24 which which WDT cord-344988-09vpehvf 70 25 leads lead VBZ cord-344988-09vpehvf 70 26 to to IN cord-344988-09vpehvf 70 27 an an DT cord-344988-09vpehvf 70 28 impairment impairment NN cord-344988-09vpehvf 70 29 of of IN cord-344988-09vpehvf 70 30 immune immune JJ cord-344988-09vpehvf 70 31 function function NN cord-344988-09vpehvf 70 32 [ [ -LRB- cord-344988-09vpehvf 70 33 57 57 CD cord-344988-09vpehvf 70 34 , , , cord-344988-09vpehvf 70 35 131 131 CD cord-344988-09vpehvf 70 36 ] ] -RRB- cord-344988-09vpehvf 70 37 . . . cord-344988-09vpehvf 71 1 This this DT cord-344988-09vpehvf 71 2 review review NN cord-344988-09vpehvf 71 3 aims aim VBZ cord-344988-09vpehvf 71 4 to to TO cord-344988-09vpehvf 71 5 summarize summarize VB cord-344988-09vpehvf 71 6 current current JJ cord-344988-09vpehvf 71 7 knowledge knowledge NN cord-344988-09vpehvf 71 8 about about IN cord-344988-09vpehvf 71 9 both both CC cord-344988-09vpehvf 71 10 the the DT cord-344988-09vpehvf 71 11 beneficial beneficial JJ cord-344988-09vpehvf 71 12 and and CC cord-344988-09vpehvf 71 13 adverse adverse JJ cord-344988-09vpehvf 71 14 effects effect NNS cord-344988-09vpehvf 71 15 of of IN cord-344988-09vpehvf 71 16 zinc zinc NN cord-344988-09vpehvf 71 17 supplementation supplementation NN cord-344988-09vpehvf 71 18 on on IN cord-344988-09vpehvf 71 19 the the DT cord-344988-09vpehvf 71 20 immune immune JJ cord-344988-09vpehvf 71 21 system system NN cord-344988-09vpehvf 71 22 and and CC cord-344988-09vpehvf 71 23 to to TO cord-344988-09vpehvf 71 24 discuss discuss VB cord-344988-09vpehvf 71 25 the the DT cord-344988-09vpehvf 71 26 possible possible JJ cord-344988-09vpehvf 71 27 molecular molecular JJ cord-344988-09vpehvf 71 28 mechanisms mechanism NNS cord-344988-09vpehvf 71 29 by by IN cord-344988-09vpehvf 71 30 which which WDT cord-344988-09vpehvf 71 31 these these DT cord-344988-09vpehvf 71 32 effects effect NNS cord-344988-09vpehvf 71 33 could could MD cord-344988-09vpehvf 71 34 be be VB cord-344988-09vpehvf 71 35 mediated mediate VBN cord-344988-09vpehvf 71 36 . . . cord-344988-09vpehvf 72 1 Table table NN cord-344988-09vpehvf 72 2 3 3 CD cord-344988-09vpehvf 72 3 specifies specify VBZ cord-344988-09vpehvf 72 4 different different JJ cord-344988-09vpehvf 72 5 zinc zinc NN cord-344988-09vpehvf 72 6 supplementation supplementation NN cord-344988-09vpehvf 72 7 studies study NNS cord-344988-09vpehvf 72 8 dealing deal VBG cord-344988-09vpehvf 72 9 with with IN cord-344988-09vpehvf 72 10 diseases disease NNS cord-344988-09vpehvf 72 11 induced induce VBN cord-344988-09vpehvf 72 12 by by IN cord-344988-09vpehvf 72 13 viral viral JJ cord-344988-09vpehvf 72 14 pathogens pathogen NNS cord-344988-09vpehvf 72 15 . . . cord-344988-09vpehvf 73 1 The the DT cord-344988-09vpehvf 73 2 common common JJ cord-344988-09vpehvf 73 3 cold cold NN cord-344988-09vpehvf 73 4 is be VBZ cord-344988-09vpehvf 73 5 a a DT cord-344988-09vpehvf 73 6 syndrome syndrome NN cord-344988-09vpehvf 73 7 caused cause VBN cord-344988-09vpehvf 73 8 by by IN cord-344988-09vpehvf 73 9 a a DT cord-344988-09vpehvf 73 10 multitude multitude NN cord-344988-09vpehvf 73 11 of of IN cord-344988-09vpehvf 73 12 different different JJ cord-344988-09vpehvf 73 13 viruses virus NNS cord-344988-09vpehvf 73 14 , , , cord-344988-09vpehvf 73 15 many many JJ cord-344988-09vpehvf 73 16 of of IN cord-344988-09vpehvf 73 17 them -PRON- PRP cord-344988-09vpehvf 73 18 belonging belong VBG cord-344988-09vpehvf 73 19 to to IN cord-344988-09vpehvf 73 20 the the DT cord-344988-09vpehvf 73 21 rhino rhino NN cord-344988-09vpehvf 73 22 - - HYPH cord-344988-09vpehvf 73 23 and and CC cord-344988-09vpehvf 73 24 coronaviruses coronaviruse NNS cord-344988-09vpehvf 73 25 . . . cord-344988-09vpehvf 74 1 For for IN cord-344988-09vpehvf 74 2 this this DT cord-344988-09vpehvf 74 3 disease disease NN cord-344988-09vpehvf 74 4 , , , cord-344988-09vpehvf 74 5 the the DT cord-344988-09vpehvf 74 6 use use NN cord-344988-09vpehvf 74 7 of of IN cord-344988-09vpehvf 74 8 zinc zinc NN cord-344988-09vpehvf 74 9 has have VBZ cord-344988-09vpehvf 74 10 been be VBN cord-344988-09vpehvf 74 11 extensively extensively RB cord-344988-09vpehvf 74 12 investigated investigate VBN cord-344988-09vpehvf 74 13 . . . cord-344988-09vpehvf 75 1 The the DT cord-344988-09vpehvf 75 2 individual individual JJ cord-344988-09vpehvf 75 3 studies study NNS cord-344988-09vpehvf 75 4 will will MD cord-344988-09vpehvf 75 5 not not RB cord-344988-09vpehvf 75 6 be be VB cord-344988-09vpehvf 75 7 discussed discuss VBN cord-344988-09vpehvf 75 8 in in IN cord-344988-09vpehvf 75 9 detail detail NN cord-344988-09vpehvf 75 10 here here RB cord-344988-09vpehvf 75 11 because because IN cord-344988-09vpehvf 75 12 they -PRON- PRP cord-344988-09vpehvf 75 13 have have VBP cord-344988-09vpehvf 75 14 already already RB cord-344988-09vpehvf 75 15 been be VBN cord-344988-09vpehvf 75 16 summarized summarize VBN cord-344988-09vpehvf 75 17 and and CC cord-344988-09vpehvf 75 18 compared compare VBN cord-344988-09vpehvf 75 19 elsewhere elsewhere RB cord-344988-09vpehvf 75 20 [ [ -LRB- cord-344988-09vpehvf 75 21 64 64 CD cord-344988-09vpehvf 75 22 , , , cord-344988-09vpehvf 75 23 66 66 CD cord-344988-09vpehvf 75 24 , , , cord-344988-09vpehvf 75 25 67 67 CD cord-344988-09vpehvf 75 26 ] ] -RRB- cord-344988-09vpehvf 75 27 . . . cord-344988-09vpehvf 76 1 In in IN cord-344988-09vpehvf 76 2 these these DT cord-344988-09vpehvf 76 3 studies study NNS cord-344988-09vpehvf 76 4 , , , cord-344988-09vpehvf 76 5 which which WDT cord-344988-09vpehvf 76 6 used use VBD cord-344988-09vpehvf 76 7 4.5 4.5 CD cord-344988-09vpehvf 76 8 - - SYM cord-344988-09vpehvf 76 9 23.7 23.7 CD cord-344988-09vpehvf 76 10 mg mg NNP cord-344988-09vpehvf 76 11 elemental elemental JJ cord-344988-09vpehvf 76 12 zinc zinc NN cord-344988-09vpehvf 76 13 per per IN cord-344988-09vpehvf 76 14 single single JJ cord-344988-09vpehvf 76 15 dose dose NN cord-344988-09vpehvf 76 16 , , , cord-344988-09vpehvf 76 17 the the DT cord-344988-09vpehvf 76 18 results result NNS cord-344988-09vpehvf 76 19 are be VBP cord-344988-09vpehvf 76 20 as as RB cord-344988-09vpehvf 76 21 inconsistent inconsistent JJ cord-344988-09vpehvf 76 22 as as IN cord-344988-09vpehvf 76 23 the the DT cord-344988-09vpehvf 76 24 treatment treatment NN cord-344988-09vpehvf 76 25 conditions condition NNS cord-344988-09vpehvf 76 26 . . . cord-344988-09vpehvf 77 1 In in IN cord-344988-09vpehvf 77 2 a a DT cord-344988-09vpehvf 77 3 review review NN cord-344988-09vpehvf 77 4 by by IN cord-344988-09vpehvf 77 5 Hulisz Hulisz NNP cord-344988-09vpehvf 77 6 [ [ -LRB- cord-344988-09vpehvf 77 7 64 64 CD cord-344988-09vpehvf 77 8 ] ] -RRB- cord-344988-09vpehvf 77 9 it -PRON- PRP cord-344988-09vpehvf 77 10 was be VBD cord-344988-09vpehvf 77 11 concluded conclude VBN cord-344988-09vpehvf 77 12 that that IN cord-344988-09vpehvf 77 13 zinc zinc NN cord-344988-09vpehvf 77 14 can can MD cord-344988-09vpehvf 77 15 be be VB cord-344988-09vpehvf 77 16 effective effective JJ cord-344988-09vpehvf 77 17 in in IN cord-344988-09vpehvf 77 18 reducing reduce VBG cord-344988-09vpehvf 77 19 the the DT cord-344988-09vpehvf 77 20 duration duration NN cord-344988-09vpehvf 77 21 of of IN cord-344988-09vpehvf 77 22 the the DT cord-344988-09vpehvf 77 23 common common JJ cord-344988-09vpehvf 77 24 cold cold NN cord-344988-09vpehvf 77 25 when when WRB cord-344988-09vpehvf 77 26 administered administer VBN cord-344988-09vpehvf 77 27 within within IN cord-344988-09vpehvf 77 28 24 24 CD cord-344988-09vpehvf 77 29 h h NN cord-344988-09vpehvf 77 30 after after IN cord-344988-09vpehvf 77 31 the the DT cord-344988-09vpehvf 77 32 onset onset NN cord-344988-09vpehvf 77 33 of of IN cord-344988-09vpehvf 77 34 symptoms symptom NNS cord-344988-09vpehvf 77 35 . . . cord-344988-09vpehvf 78 1 A a DT cord-344988-09vpehvf 78 2 recent recent JJ cord-344988-09vpehvf 78 3 study study NN cord-344988-09vpehvf 78 4 in in IN cord-344988-09vpehvf 78 5 children child NNS cord-344988-09vpehvf 78 6 indicates indicate VBZ cord-344988-09vpehvf 78 7 that that IN cord-344988-09vpehvf 78 8 zinc zinc NN cord-344988-09vpehvf 78 9 may may MD cord-344988-09vpehvf 78 10 also also RB cord-344988-09vpehvf 78 11 have have VB cord-344988-09vpehvf 78 12 a a DT cord-344988-09vpehvf 78 13 prophylactic prophylactic JJ cord-344988-09vpehvf 78 14 effect effect NN cord-344988-09vpehvf 78 15 and and CC cord-344988-09vpehvf 78 16 the the DT cord-344988-09vpehvf 78 17 administration administration NN cord-344988-09vpehvf 78 18 of of IN cord-344988-09vpehvf 78 19 zinc zinc NN cord-344988-09vpehvf 78 20 results result VBZ cord-344988-09vpehvf 78 21 in in IN cord-344988-09vpehvf 78 22 a a DT cord-344988-09vpehvf 78 23 lower low JJR cord-344988-09vpehvf 78 24 mean mean JJ cord-344988-09vpehvf 78 25 number number NN cord-344988-09vpehvf 78 26 of of IN cord-344988-09vpehvf 78 27 colds cold NNS cord-344988-09vpehvf 78 28 [ [ -LRB- cord-344988-09vpehvf 78 29 78 78 CD cord-344988-09vpehvf 78 30 ] ] -RRB- cord-344988-09vpehvf 78 31 . . . cord-344988-09vpehvf 79 1 However however RB cord-344988-09vpehvf 79 2 , , , cord-344988-09vpehvf 79 3 two two CD cord-344988-09vpehvf 79 4 metaanalyses metaanalyse NNS cord-344988-09vpehvf 79 5 did do VBD cord-344988-09vpehvf 79 6 not not RB cord-344988-09vpehvf 79 7 confirm confirm VB cord-344988-09vpehvf 79 8 an an DT cord-344988-09vpehvf 79 9 effectiveness effectiveness NN cord-344988-09vpehvf 79 10 of of IN cord-344988-09vpehvf 79 11 zinc- zinc- NN cord-344988-09vpehvf 79 12 -lozenges -lozenge NNS cord-344988-09vpehvf 79 13 in in IN cord-344988-09vpehvf 79 14 reducing reduce VBG cord-344988-09vpehvf 79 15 the the DT cord-344988-09vpehvf 79 16 symptoms symptom NNS cord-344988-09vpehvf 79 17 of of IN cord-344988-09vpehvf 79 18 the the DT cord-344988-09vpehvf 79 19 common common JJ cord-344988-09vpehvf 79 20 cold cold NN cord-344988-09vpehvf 79 21 after after IN cord-344988-09vpehvf 79 22 seven seven CD cord-344988-09vpehvf 79 23 days day NNS cord-344988-09vpehvf 79 24 [ [ -LRB- cord-344988-09vpehvf 79 25 66 66 CD cord-344988-09vpehvf 79 26 , , , cord-344988-09vpehvf 79 27 67 67 CD cord-344988-09vpehvf 79 28 ] ] -RRB- cord-344988-09vpehvf 79 29 . . . cord-344988-09vpehvf 80 1 Many many JJ cord-344988-09vpehvf 80 2 potential potential JJ cord-344988-09vpehvf 80 3 mechanisms mechanism NNS cord-344988-09vpehvf 80 4 have have VBP cord-344988-09vpehvf 80 5 been be VBN cord-344988-09vpehvf 80 6 suggested suggest VBN cord-344988-09vpehvf 80 7 that that WDT cord-344988-09vpehvf 80 8 could could MD cord-344988-09vpehvf 80 9 explain explain VB cord-344988-09vpehvf 80 10 a a DT cord-344988-09vpehvf 80 11 potential potential JJ cord-344988-09vpehvf 80 12 beneficial beneficial JJ cord-344988-09vpehvf 80 13 effect effect NN cord-344988-09vpehvf 80 14 of of IN cord-344988-09vpehvf 80 15 zinc zinc NN cord-344988-09vpehvf 80 16 . . . cord-344988-09vpehvf 81 1 These these DT cord-344988-09vpehvf 81 2 include include VBP cord-344988-09vpehvf 81 3 effects effect NNS cord-344988-09vpehvf 81 4 of of IN cord-344988-09vpehvf 81 5 zinc zinc NN cord-344988-09vpehvf 81 6 on on IN cord-344988-09vpehvf 81 7 viral viral JJ cord-344988-09vpehvf 81 8 replication replication NN cord-344988-09vpehvf 81 9 and and CC cord-344988-09vpehvf 81 10 infection infection NN cord-344988-09vpehvf 81 11 of of IN cord-344988-09vpehvf 81 12 cells cell NNS cord-344988-09vpehvf 81 13 on on IN cord-344988-09vpehvf 81 14 the the DT cord-344988-09vpehvf 81 15 one one CD cord-344988-09vpehvf 81 16 hand hand NN cord-344988-09vpehvf 81 17 and and CC cord-344988-09vpehvf 81 18 the the DT cord-344988-09vpehvf 81 19 immune immune JJ cord-344988-09vpehvf 81 20 system system NN cord-344988-09vpehvf 81 21 , , , cord-344988-09vpehvf 81 22 in in IN cord-344988-09vpehvf 81 23 particular particular JJ cord-344988-09vpehvf 81 24 cytokine cytokine NN cord-344988-09vpehvf 81 25 production production NN cord-344988-09vpehvf 81 26 and and CC cord-344988-09vpehvf 81 27 modulation modulation NN cord-344988-09vpehvf 81 28 of of IN cord-344988-09vpehvf 81 29 the the DT cord-344988-09vpehvf 81 30 activity activity NN cord-344988-09vpehvf 81 31 of of IN cord-344988-09vpehvf 81 32 immune immune JJ cord-344988-09vpehvf 81 33 cells cell NNS cord-344988-09vpehvf 81 34 , , , cord-344988-09vpehvf 81 35 on on IN cord-344988-09vpehvf 81 36 the the DT cord-344988-09vpehvf 81 37 other other JJ cord-344988-09vpehvf 81 38 . . . cord-344988-09vpehvf 82 1 Zinc zinc NN cord-344988-09vpehvf 82 2 inhibits inhibit VBZ cord-344988-09vpehvf 82 3 the the DT cord-344988-09vpehvf 82 4 formation formation NN cord-344988-09vpehvf 82 5 of of IN cord-344988-09vpehvf 82 6 viral viral JJ cord-344988-09vpehvf 82 7 capsid capsid NN cord-344988-09vpehvf 82 8 proteins protein NNS cord-344988-09vpehvf 82 9 and and CC cord-344988-09vpehvf 82 10 the the DT cord-344988-09vpehvf 82 11 rhinovirus rhinovirus NN cord-344988-09vpehvf 82 12 3C 3C NNP cord-344988-09vpehvf 82 13 protease protease NN cord-344988-09vpehvf 82 14 , , , cord-344988-09vpehvf 82 15 thus thus RB cord-344988-09vpehvf 82 16 preventing prevent VBG cord-344988-09vpehvf 82 17 the the DT cord-344988-09vpehvf 82 18 replication replication NN cord-344988-09vpehvf 82 19 of of IN cord-344988-09vpehvf 82 20 rhinoviruses rhinovirus NNS cord-344988-09vpehvf 82 21 in in IN cord-344988-09vpehvf 82 22 vitro vitro FW cord-344988-09vpehvf 82 23 . . . cord-344988-09vpehvf 83 1 However however RB cord-344988-09vpehvf 83 2 , , , cord-344988-09vpehvf 83 3 this this DT cord-344988-09vpehvf 83 4 remains remain VBZ cord-344988-09vpehvf 83 5 to to TO cord-344988-09vpehvf 83 6 be be VB cord-344988-09vpehvf 83 7 demonstrated demonstrate VBN cord-344988-09vpehvf 83 8 in in IN cord-344988-09vpehvf 83 9 vivo vivo NNP cord-344988-09vpehvf 83 10 [ [ -LRB- cord-344988-09vpehvf 83 11 50 50 CD cord-344988-09vpehvf 83 12 , , , cord-344988-09vpehvf 83 13 73 73 CD cord-344988-09vpehvf 83 14 , , , cord-344988-09vpehvf 83 15 74 74 CD cord-344988-09vpehvf 83 16 , , , cord-344988-09vpehvf 83 17 158 158 CD cord-344988-09vpehvf 83 18 ] ] -RRB- cord-344988-09vpehvf 83 19 . . . cord-344988-09vpehvf 84 1 Alternatively alternatively RB cord-344988-09vpehvf 84 2 , , , cord-344988-09vpehvf 84 3 zinc zinc NN cord-344988-09vpehvf 84 4 could could MD cord-344988-09vpehvf 84 5 interact interact VB cord-344988-09vpehvf 84 6 with with IN cord-344988-09vpehvf 84 7 the the DT cord-344988-09vpehvf 84 8 binding binding NN cord-344988-09vpehvf 84 9 of of IN cord-344988-09vpehvf 84 10 the the DT cord-344988-09vpehvf 84 11 rhinovirus rhinovirus NN cord-344988-09vpehvf 84 12 to to IN cord-344988-09vpehvf 84 13 the the DT cord-344988-09vpehvf 84 14 intercellular intercellular JJ cord-344988-09vpehvf 84 15 adhesion adhesion NN cord-344988-09vpehvf 84 16 molecule-1 molecule-1 NN cord-344988-09vpehvf 84 17 ( ( -LRB- cord-344988-09vpehvf 84 18 ICAM-1 ICAM-1 NNP cord-344988-09vpehvf 84 19 ) ) -RRB- cord-344988-09vpehvf 84 20 , , , cord-344988-09vpehvf 84 21 an an DT cord-344988-09vpehvf 84 22 event event NN cord-344988-09vpehvf 84 23 that that WDT cord-344988-09vpehvf 84 24 is be VBZ cord-344988-09vpehvf 84 25 required require VBN cord-344988-09vpehvf 84 26 for for IN cord-344988-09vpehvf 84 27 invasion invasion NN cord-344988-09vpehvf 84 28 of of IN cord-344988-09vpehvf 84 29 cells cell NNS cord-344988-09vpehvf 84 30 of of IN cord-344988-09vpehvf 84 31 the the DT cord-344988-09vpehvf 84 32 nasal nasal NN cord-344988-09vpehvf 84 33 epithelium epithelium NN cord-344988-09vpehvf 84 34 . . . cord-344988-09vpehvf 85 1 It -PRON- PRP cord-344988-09vpehvf 85 2 was be VBD cord-344988-09vpehvf 85 3 hypothesized hypothesize VBN cord-344988-09vpehvf 85 4 that that IN cord-344988-09vpehvf 85 5 the the DT cord-344988-09vpehvf 85 6 positively positively RB cord-344988-09vpehvf 85 7 charged charge VBN cord-344988-09vpehvf 85 8 zinc zinc NN cord-344988-09vpehvf 85 9 ions ion NNS cord-344988-09vpehvf 85 10 can can MD cord-344988-09vpehvf 85 11 bind bind VB cord-344988-09vpehvf 85 12 to to IN cord-344988-09vpehvf 85 13 the the DT cord-344988-09vpehvf 85 14 negatively negatively RB cord-344988-09vpehvf 85 15 charged charge VBN cord-344988-09vpehvf 85 16 regions region NNS cord-344988-09vpehvf 85 17 at at IN cord-344988-09vpehvf 85 18 the the DT cord-344988-09vpehvf 85 19 carboxyl carboxyl NN cord-344988-09vpehvf 85 20 termini termini NN cord-344988-09vpehvf 85 21 of of IN cord-344988-09vpehvf 85 22 rhinovirus rhinovirus NN cord-344988-09vpehvf 85 23 coat coat NN cord-344988-09vpehvf 85 24 proteins protein NNS cord-344988-09vpehvf 85 25 , , , cord-344988-09vpehvf 85 26 thereby thereby RB cord-344988-09vpehvf 85 27 preventing prevent VBG cord-344988-09vpehvf 85 28 the the DT cord-344988-09vpehvf 85 29 binding binding NN cord-344988-09vpehvf 85 30 to to IN cord-344988-09vpehvf 85 31 ICAM-1 ICAM-1 NNP cord-344988-09vpehvf 85 32 [ [ -LRB- cord-344988-09vpehvf 85 33 64 64 CD cord-344988-09vpehvf 85 34 , , , cord-344988-09vpehvf 85 35 102 102 CD cord-344988-09vpehvf 85 36 ] ] -RRB- cord-344988-09vpehvf 85 37 . . . cord-344988-09vpehvf 86 1 In in IN cord-344988-09vpehvf 86 2 addition addition NN cord-344988-09vpehvf 86 3 , , , cord-344988-09vpehvf 86 4 zinc zinc NN cord-344988-09vpehvf 86 5 may may MD cord-344988-09vpehvf 86 6 protect protect VB cord-344988-09vpehvf 86 7 or or CC cord-344988-09vpehvf 86 8 stabilize stabilize VB cord-344988-09vpehvf 86 9 the the DT cord-344988-09vpehvf 86 10 cell cell NN cord-344988-09vpehvf 86 11 membrane membrane NN cord-344988-09vpehvf 86 12 [ [ -LRB- cord-344988-09vpehvf 86 13 107 107 CD cord-344988-09vpehvf 86 14 ] ] -RRB- cord-344988-09vpehvf 86 15 , , , cord-344988-09vpehvf 86 16 which which WDT cord-344988-09vpehvf 86 17 could could MD cord-344988-09vpehvf 86 18 also also RB cord-344988-09vpehvf 86 19 contribute contribute VB cord-344988-09vpehvf 86 20 to to IN cord-344988-09vpehvf 86 21 an an DT cord-344988-09vpehvf 86 22 inhibition inhibition NN cord-344988-09vpehvf 86 23 of of IN cord-344988-09vpehvf 86 24 the the DT cord-344988-09vpehvf 86 25 entry entry NN cord-344988-09vpehvf 86 26 of of IN cord-344988-09vpehvf 86 27 the the DT cord-344988-09vpehvf 86 28 virus virus NN cord-344988-09vpehvf 86 29 into into IN cord-344988-09vpehvf 86 30 the the DT cord-344988-09vpehvf 86 31 cell cell NN cord-344988-09vpehvf 86 32 . . . cord-344988-09vpehvf 87 1 In in IN cord-344988-09vpehvf 87 2 a a DT cord-344988-09vpehvf 87 3 similar similar JJ cord-344988-09vpehvf 87 4 manner manner NN cord-344988-09vpehvf 87 5 to to IN cord-344988-09vpehvf 87 6 viral viral JJ cord-344988-09vpehvf 87 7 binding binding NN cord-344988-09vpehvf 87 8 of of IN cord-344988-09vpehvf 87 9 ICAM-1 icam-1 NN cord-344988-09vpehvf 87 10 , , , cord-344988-09vpehvf 87 11 zinc zinc NN cord-344988-09vpehvf 87 12 might may MD cord-344988-09vpehvf 87 13 also also RB cord-344988-09vpehvf 87 14 interfere interfere VB cord-344988-09vpehvf 87 15 with with IN cord-344988-09vpehvf 87 16 the the DT cord-344988-09vpehvf 87 17 binding binding NN cord-344988-09vpehvf 87 18 of of IN cord-344988-09vpehvf 87 19 leukocyte leukocyte NN cord-344988-09vpehvf 87 20 function function NN cord-344988-09vpehvf 87 21 - - HYPH cord-344988-09vpehvf 87 22 associated associate VBN cord-344988-09vpehvf 87 23 antigen-1 antigen-1 NNP cord-344988-09vpehvf 87 24 to to IN cord-344988-09vpehvf 87 25 ICAM-1 ICAM-1 NNP cord-344988-09vpehvf 87 26 , , , cord-344988-09vpehvf 87 27 thus thus RB cord-344988-09vpehvf 87 28 suppressing suppress VBG cord-344988-09vpehvf 87 29 inflammation inflammation NN cord-344988-09vpehvf 87 30 [ [ -LRB- cord-344988-09vpehvf 87 31 103 103 CD cord-344988-09vpehvf 87 32 ] ] -RRB- cord-344988-09vpehvf 87 33 . . . cord-344988-09vpehvf 88 1 Z Z NNP cord-344988-09vpehvf 88 2 -zinc -zinc NNP cord-344988-09vpehvf 88 3 , , , cord-344988-09vpehvf 88 4 P P NNP cord-344988-09vpehvf 88 5 -placebo -placebo NNP cord-344988-09vpehvf 88 6 , , , cord-344988-09vpehvf 88 7 C C NNP cord-344988-09vpehvf 88 8 -control -control NN cord-344988-09vpehvf 88 9 . . . cord-344988-09vpehvf 89 1 a a DT cord-344988-09vpehvf 89 2 Values value NNS cord-344988-09vpehvf 89 3 are be VBP cord-344988-09vpehvf 89 4 given give VBN cord-344988-09vpehvf 89 5 as as IN cord-344988-09vpehvf 89 6 the the DT cord-344988-09vpehvf 89 7 amount amount NN cord-344988-09vpehvf 89 8 of of IN cord-344988-09vpehvf 89 9 supplement supplement NN cord-344988-09vpehvf 89 10 unless unless IN cord-344988-09vpehvf 89 11 indicated indicate VBN cord-344988-09vpehvf 89 12 otherwise otherwise RB cord-344988-09vpehvf 89 13 . . . cord-344988-09vpehvf 90 1 The the DT cord-344988-09vpehvf 90 2 elemental elemental JJ cord-344988-09vpehvf 90 3 zinc zinc NN cord-344988-09vpehvf 90 4 content content NN cord-344988-09vpehvf 90 5 is be VBZ cord-344988-09vpehvf 90 6 given give VBN cord-344988-09vpehvf 90 7 as as IN cord-344988-09vpehvf 90 8 provided provide VBN cord-344988-09vpehvf 90 9 in in IN cord-344988-09vpehvf 90 10 the the DT cord-344988-09vpehvf 90 11 respective respective JJ cord-344988-09vpehvf 90 12 publication publication NN cord-344988-09vpehvf 90 13 and and CC cord-344988-09vpehvf 90 14 may may MD cord-344988-09vpehvf 90 15 not not RB cord-344988-09vpehvf 90 16 always always RB cord-344988-09vpehvf 90 17 correspond correspond VB cord-344988-09vpehvf 90 18 to to IN cord-344988-09vpehvf 90 19 Table Table NNP cord-344988-09vpehvf 90 20 1 1 CD cord-344988-09vpehvf 90 21 . . . cord-344988-09vpehvf 91 1 Among among IN cord-344988-09vpehvf 91 2 the the DT cord-344988-09vpehvf 91 3 immunomodulatory immunomodulatory JJ cord-344988-09vpehvf 91 4 effects effect NNS cord-344988-09vpehvf 91 5 of of IN cord-344988-09vpehvf 91 6 zinc zinc NN cord-344988-09vpehvf 91 7 that that WDT cord-344988-09vpehvf 91 8 could could MD cord-344988-09vpehvf 91 9 counteract counteract VB cord-344988-09vpehvf 91 10 viral viral JJ cord-344988-09vpehvf 91 11 infections infection NNS cord-344988-09vpehvf 91 12 is be VBZ cord-344988-09vpehvf 91 13 its -PRON- PRP$ cord-344988-09vpehvf 91 14 influence influence NN cord-344988-09vpehvf 91 15 on on IN cord-344988-09vpehvf 91 16 the the DT cord-344988-09vpehvf 91 17 synthesis synthesis NN cord-344988-09vpehvf 91 18 of of IN cord-344988-09vpehvf 91 19 cytokines cytokine NNS cord-344988-09vpehvf 91 20 . . . cord-344988-09vpehvf 92 1 In in IN cord-344988-09vpehvf 92 2 vitro vitro FW cord-344988-09vpehvf 92 3 , , , cord-344988-09vpehvf 92 4 zinc zinc NN cord-344988-09vpehvf 92 5 induces induce VBZ cord-344988-09vpehvf 92 6 the the DT cord-344988-09vpehvf 92 7 production production NN cord-344988-09vpehvf 92 8 of of IN cord-344988-09vpehvf 92 9 antiviral antiviral JJ cord-344988-09vpehvf 92 10 interferon interferon NN cord-344988-09vpehvf 92 11 ( ( -LRB- cord-344988-09vpehvf 92 12 IFN)-α IFN)-α NNP cord-344988-09vpehvf 92 13 as as RB cord-344988-09vpehvf 92 14 well well RB cord-344988-09vpehvf 92 15 as as IN cord-344988-09vpehvf 92 16 IFN IFN NNP cord-344988-09vpehvf 92 17 - - HYPH cord-344988-09vpehvf 92 18 γ γ NNP cord-344988-09vpehvf 92 19 [ [ -LRB- cord-344988-09vpehvf 92 20 19 19 CD cord-344988-09vpehvf 92 21 , , , cord-344988-09vpehvf 92 22 136 136 CD cord-344988-09vpehvf 92 23 ] ] -RRB- cord-344988-09vpehvf 93 1 and and CC cord-344988-09vpehvf 93 2 it -PRON- PRP cord-344988-09vpehvf 93 3 can can MD cord-344988-09vpehvf 93 4 potentiate potentiate VB cord-344988-09vpehvf 93 5 the the DT cord-344988-09vpehvf 93 6 antiviral antiviral JJ cord-344988-09vpehvf 93 7 action action NN cord-344988-09vpehvf 93 8 of of IN cord-344988-09vpehvf 93 9 IFN IFN NNP cord-344988-09vpehvf 93 10 - - HYPH cord-344988-09vpehvf 93 11 α α NNP cord-344988-09vpehvf 93 12 , , , cord-344988-09vpehvf 93 13 but but CC cord-344988-09vpehvf 93 14 not not RB cord-344988-09vpehvf 93 15 of of IN cord-344988-09vpehvf 93 16 IFN IFN NNP cord-344988-09vpehvf 93 17 - - HYPH cord-344988-09vpehvf 93 18 γ γ NNP cord-344988-09vpehvf 93 19 [ [ -LRB- cord-344988-09vpehvf 93 20 11 11 CD cord-344988-09vpehvf 93 21 ] ] -RRB- cord-344988-09vpehvf 93 22 . . . cord-344988-09vpehvf 94 1 Besides besides IN cord-344988-09vpehvf 94 2 this this DT cord-344988-09vpehvf 94 3 , , , cord-344988-09vpehvf 94 4 clearance clearance NN cord-344988-09vpehvf 94 5 of of IN cord-344988-09vpehvf 94 6 viral viral JJ cord-344988-09vpehvf 94 7 infections infection NNS cord-344988-09vpehvf 94 8 requires require VBZ cord-344988-09vpehvf 94 9 cytotoxic cytotoxic JJ cord-344988-09vpehvf 94 10 T t NN cord-344988-09vpehvf 94 11 lymphocytes lymphocyte NNS cord-344988-09vpehvf 94 12 , , , cord-344988-09vpehvf 94 13 which which WDT cord-344988-09vpehvf 94 14 are be VBP cord-344988-09vpehvf 94 15 highly highly RB cord-344988-09vpehvf 94 16 dependent dependent JJ cord-344988-09vpehvf 94 17 on on IN cord-344988-09vpehvf 94 18 zinc zinc NN cord-344988-09vpehvf 94 19 , , , cord-344988-09vpehvf 94 20 as as IN cord-344988-09vpehvf 94 21 discussed discuss VBN cord-344988-09vpehvf 94 22 above above RB cord-344988-09vpehvf 94 23 . . . cord-344988-09vpehvf 95 1 Other other JJ cord-344988-09vpehvf 95 2 potential potential JJ cord-344988-09vpehvf 95 3 mechanisms mechanism NNS cord-344988-09vpehvf 95 4 by by IN cord-344988-09vpehvf 95 5 which which WDT cord-344988-09vpehvf 95 6 zinc zinc NN cord-344988-09vpehvf 95 7 could could MD cord-344988-09vpehvf 95 8 act act VB cord-344988-09vpehvf 95 9 against against IN cord-344988-09vpehvf 95 10 the the DT cord-344988-09vpehvf 95 11 common common JJ cord-344988-09vpehvf 95 12 cold cold NN cord-344988-09vpehvf 95 13 include include VBP cord-344988-09vpehvf 95 14 an an DT cord-344988-09vpehvf 95 15 inhibitory inhibitory JJ cord-344988-09vpehvf 95 16 effect effect NN cord-344988-09vpehvf 95 17 of of IN cord-344988-09vpehvf 95 18 zinc zinc NN cord-344988-09vpehvf 95 19 on on IN cord-344988-09vpehvf 95 20 human human JJ cord-344988-09vpehvf 95 21 prostaglandin prostaglandin NN cord-344988-09vpehvf 95 22 metabolism metabolism NN cord-344988-09vpehvf 95 23 [ [ -LRB- cord-344988-09vpehvf 95 24 71 71 CD cord-344988-09vpehvf 95 25 ] ] -RRB- cord-344988-09vpehvf 95 26 , , , cord-344988-09vpehvf 95 27 which which WDT cord-344988-09vpehvf 95 28 may may MD cord-344988-09vpehvf 95 29 account account VB cord-344988-09vpehvf 95 30 for for IN cord-344988-09vpehvf 95 31 the the DT cord-344988-09vpehvf 95 32 ability ability NN cord-344988-09vpehvf 95 33 of of IN cord-344988-09vpehvf 95 34 zinc zinc NN cord-344988-09vpehvf 95 35 to to TO cord-344988-09vpehvf 95 36 reduce reduce VB cord-344988-09vpehvf 95 37 symptoms symptom NNS cord-344988-09vpehvf 95 38 of of IN cord-344988-09vpehvf 95 39 the the DT cord-344988-09vpehvf 95 40 common common JJ cord-344988-09vpehvf 95 41 cold cold NN cord-344988-09vpehvf 95 42 . . . cord-344988-09vpehvf 96 1 Finally finally RB cord-344988-09vpehvf 96 2 , , , cord-344988-09vpehvf 96 3 a a DT cord-344988-09vpehvf 96 4 zinc zinc NN cord-344988-09vpehvf 96 5 - - HYPH cord-344988-09vpehvf 96 6 induced induce VBN cord-344988-09vpehvf 96 7 alteration alteration NN cord-344988-09vpehvf 96 8 of of IN cord-344988-09vpehvf 96 9 the the DT cord-344988-09vpehvf 96 10 capillary capillary JJ cord-344988-09vpehvf 96 11 epithelium epithelium NN cord-344988-09vpehvf 96 12 might may MD cord-344988-09vpehvf 96 13 inhibit inhibit VB cord-344988-09vpehvf 96 14 transcapillary transcapillary JJ cord-344988-09vpehvf 96 15 movement movement NN cord-344988-09vpehvf 96 16 of of IN cord-344988-09vpehvf 96 17 plasma plasma NN cord-344988-09vpehvf 96 18 proteins protein NNS cord-344988-09vpehvf 96 19 and and CC cord-344988-09vpehvf 96 20 reduce reduce VB cord-344988-09vpehvf 96 21 local local JJ cord-344988-09vpehvf 96 22 edema edema NN cord-344988-09vpehvf 96 23 , , , cord-344988-09vpehvf 96 24 inflammation inflammation NN cord-344988-09vpehvf 96 25 , , , cord-344988-09vpehvf 96 26 exudation exudation NN cord-344988-09vpehvf 96 27 , , , cord-344988-09vpehvf 96 28 and and CC cord-344988-09vpehvf 96 29 mucus mucus NN cord-344988-09vpehvf 96 30 secretion secretion NN cord-344988-09vpehvf 96 31 [ [ -LRB- cord-344988-09vpehvf 96 32 102 102 CD cord-344988-09vpehvf 96 33 ] ] -RRB- cord-344988-09vpehvf 96 34 . . . cord-344988-09vpehvf 97 1 So so RB cord-344988-09vpehvf 97 2 far far RB cord-344988-09vpehvf 97 3 it -PRON- PRP cord-344988-09vpehvf 97 4 is be VBZ cord-344988-09vpehvf 97 5 not not RB cord-344988-09vpehvf 97 6 known know VBN cord-344988-09vpehvf 97 7 which which WDT cord-344988-09vpehvf 97 8 of of IN cord-344988-09vpehvf 97 9 these these DT cord-344988-09vpehvf 97 10 explanations explanation NNS cord-344988-09vpehvf 97 11 are be VBP cord-344988-09vpehvf 97 12 relevant relevant JJ cord-344988-09vpehvf 97 13 for for IN cord-344988-09vpehvf 97 14 the the DT cord-344988-09vpehvf 97 15 proposed propose VBN cord-344988-09vpehvf 97 16 effect effect NN cord-344988-09vpehvf 97 17 of of IN cord-344988-09vpehvf 97 18 zinc zinc NN cord-344988-09vpehvf 97 19 treatment treatment NN cord-344988-09vpehvf 97 20 in in IN cord-344988-09vpehvf 97 21 vivo vivo NNP cord-344988-09vpehvf 97 22 . . . cord-344988-09vpehvf 98 1 The the DT cord-344988-09vpehvf 98 2 lack lack NN cord-344988-09vpehvf 98 3 of of IN cord-344988-09vpehvf 98 4 statistical statistical JJ cord-344988-09vpehvf 98 5 confirmation confirmation NN cord-344988-09vpehvf 98 6 of of IN cord-344988-09vpehvf 98 7 effectiveness effectiveness NN cord-344988-09vpehvf 98 8 and and CC cord-344988-09vpehvf 98 9 the the DT cord-344988-09vpehvf 98 10 plethora plethora NN cord-344988-09vpehvf 98 11 of of IN cord-344988-09vpehvf 98 12 possible possible JJ cord-344988-09vpehvf 98 13 mechanisms mechanism NNS cord-344988-09vpehvf 98 14 illustrate illustrate VBP cord-344988-09vpehvf 98 15 the the DT cord-344988-09vpehvf 98 16 need need NN cord-344988-09vpehvf 98 17 for for IN cord-344988-09vpehvf 98 18 in in IN cord-344988-09vpehvf 98 19 - - HYPH cord-344988-09vpehvf 98 20 depth depth NN cord-344988-09vpehvf 98 21 research research NN cord-344988-09vpehvf 98 22 , , , cord-344988-09vpehvf 98 23 which which WDT cord-344988-09vpehvf 98 24 may may MD cord-344988-09vpehvf 98 25 allow allow VB cord-344988-09vpehvf 98 26 using use VBG cord-344988-09vpehvf 98 27 zinc zinc NN cord-344988-09vpehvf 98 28 with with IN cord-344988-09vpehvf 98 29 higher high JJR cord-344988-09vpehvf 98 30 efficiency efficiency NN cord-344988-09vpehvf 98 31 . . . cord-344988-09vpehvf 99 1 Infection infection NN cord-344988-09vpehvf 99 2 with with IN cord-344988-09vpehvf 99 3 the the DT cord-344988-09vpehvf 99 4 human human JJ cord-344988-09vpehvf 99 5 immunodeficiency immunodeficiency NN cord-344988-09vpehvf 99 6 virus virus NN cord-344988-09vpehvf 99 7 ( ( -LRB- cord-344988-09vpehvf 99 8 HIV HIV NNP cord-344988-09vpehvf 99 9 ) ) -RRB- cord-344988-09vpehvf 99 10 results result VBZ cord-344988-09vpehvf 99 11 in in IN cord-344988-09vpehvf 99 12 the the DT cord-344988-09vpehvf 99 13 acquired acquire VBN cord-344988-09vpehvf 99 14 immune immune JJ cord-344988-09vpehvf 99 15 deficiency deficiency NN cord-344988-09vpehvf 99 16 syndrome syndrome NN cord-344988-09vpehvf 99 17 ( ( -LRB- cord-344988-09vpehvf 99 18 AIDS AIDS NNP cord-344988-09vpehvf 99 19 ) ) -RRB- cord-344988-09vpehvf 99 20 , , , cord-344988-09vpehvf 99 21 a a DT cord-344988-09vpehvf 99 22 disease disease NN cord-344988-09vpehvf 99 23 where where WRB cord-344988-09vpehvf 99 24 zinc zinc NN cord-344988-09vpehvf 99 25 application application NN cord-344988-09vpehvf 99 26 was be VBD cord-344988-09vpehvf 99 27 tested test VBN cord-344988-09vpehvf 99 28 as as IN cord-344988-09vpehvf 99 29 a a DT cord-344988-09vpehvf 99 30 supporting support VBG cord-344988-09vpehvf 99 31 therapeutic therapeutic JJ cord-344988-09vpehvf 99 32 intervention intervention NN cord-344988-09vpehvf 99 33 [ [ -LRB- cord-344988-09vpehvf 99 34 23 23 CD cord-344988-09vpehvf 99 35 ] ] -RRB- cord-344988-09vpehvf 99 36 . . . cord-344988-09vpehvf 100 1 Given give VBN cord-344988-09vpehvf 100 2 the the DT cord-344988-09vpehvf 100 3 importance importance NN cord-344988-09vpehvf 100 4 of of IN cord-344988-09vpehvf 100 5 zinc zinc NN cord-344988-09vpehvf 100 6 for for IN cord-344988-09vpehvf 100 7 the the DT cord-344988-09vpehvf 100 8 development development NN cord-344988-09vpehvf 100 9 and and CC cord-344988-09vpehvf 100 10 function function NN cord-344988-09vpehvf 100 11 of of IN cord-344988-09vpehvf 100 12 T t NN cord-344988-09vpehvf 100 13 cells cell NNS cord-344988-09vpehvf 100 14 [ [ -LRB- cord-344988-09vpehvf 100 15 46 46 CD cord-344988-09vpehvf 100 16 , , , cord-344988-09vpehvf 100 17 170 170 CD cord-344988-09vpehvf 100 18 ] ] -RRB- cord-344988-09vpehvf 100 19 , , , cord-344988-09vpehvf 100 20 this this DT cord-344988-09vpehvf 100 21 seems seem VBZ cord-344988-09vpehvf 100 22 to to TO cord-344988-09vpehvf 100 23 be be VB cord-344988-09vpehvf 100 24 a a DT cord-344988-09vpehvf 100 25 sensible sensible JJ cord-344988-09vpehvf 100 26 approach approach NN cord-344988-09vpehvf 100 27 . . . cord-344988-09vpehvf 101 1 The the DT cord-344988-09vpehvf 101 2 initial initial JJ cord-344988-09vpehvf 101 3 study study NN cord-344988-09vpehvf 101 4 found find VBD cord-344988-09vpehvf 101 5 an an DT cord-344988-09vpehvf 101 6 increase increase NN cord-344988-09vpehvf 101 7 in in IN cord-344988-09vpehvf 101 8 HLA HLA NNP cord-344988-09vpehvf 101 9 - - HYPH cord-344988-09vpehvf 101 10 DR DR NNP cord-344988-09vpehvf 101 11 positive positive JJ cord-344988-09vpehvf 101 12 cells cell NNS cord-344988-09vpehvf 101 13 , , , cord-344988-09vpehvf 101 14 a a DT cord-344988-09vpehvf 101 15 stimulation stimulation NN cord-344988-09vpehvf 101 16 of of IN cord-344988-09vpehvf 101 17 lymphocyte lymphocyte NN cord-344988-09vpehvf 101 18 transformation transformation NN cord-344988-09vpehvf 101 19 by by IN cord-344988-09vpehvf 101 20 phytohemagglutinin phytohemagglutinin NNP cord-344988-09vpehvf 101 21 and and CC cord-344988-09vpehvf 101 22 concanavalin concanavalin NNP cord-344988-09vpehvf 101 23 A A NNP cord-344988-09vpehvf 101 24 , , , cord-344988-09vpehvf 101 25 and and CC cord-344988-09vpehvf 101 26 augmented augment VBN cord-344988-09vpehvf 101 27 phagocytosis phagocytosis NN cord-344988-09vpehvf 101 28 by by IN cord-344988-09vpehvf 101 29 polymorphonuclear polymorphonuclear JJ cord-344988-09vpehvf 101 30 neutrophils neutrophil NNS cord-344988-09vpehvf 101 31 [ [ -LRB- cord-344988-09vpehvf 101 32 176 176 CD cord-344988-09vpehvf 101 33 ] ] -RRB- cord-344988-09vpehvf 101 34 . . . cord-344988-09vpehvf 102 1 A a DT cord-344988-09vpehvf 102 2 report report NN cord-344988-09vpehvf 102 3 by by IN cord-344988-09vpehvf 102 4 Mocchegiani Mocchegiani NNP cord-344988-09vpehvf 102 5 et et NNP cord-344988-09vpehvf 102 6 al al NNP cord-344988-09vpehvf 102 7 . . . cord-344988-09vpehvf 103 1 [ [ -LRB- cord-344988-09vpehvf 103 2 95 95 CD cord-344988-09vpehvf 103 3 ] ] -RRB- cord-344988-09vpehvf 103 4 described describe VBD cord-344988-09vpehvf 103 5 even even RB cord-344988-09vpehvf 103 6 more more RBR cord-344988-09vpehvf 103 7 promising promising JJ cord-344988-09vpehvf 103 8 beneficial beneficial JJ cord-344988-09vpehvf 103 9 effects effect NNS cord-344988-09vpehvf 103 10 of of IN cord-344988-09vpehvf 103 11 zinc zinc NN cord-344988-09vpehvf 103 12 , , , cord-344988-09vpehvf 103 13 including include VBG cord-344988-09vpehvf 103 14 an an DT cord-344988-09vpehvf 103 15 increase increase NN cord-344988-09vpehvf 103 16 in in IN cord-344988-09vpehvf 103 17 the the DT cord-344988-09vpehvf 103 18 number number NN cord-344988-09vpehvf 103 19 of of IN cord-344988-09vpehvf 103 20 TH TH NNP cord-344988-09vpehvf 103 21 cells cell NNS cord-344988-09vpehvf 103 22 and and CC cord-344988-09vpehvf 103 23 a a DT cord-344988-09vpehvf 103 24 reduced reduce VBN cord-344988-09vpehvf 103 25 frequency frequency NN cord-344988-09vpehvf 103 26 of of IN cord-344988-09vpehvf 103 27 opportunistic opportunistic JJ cord-344988-09vpehvf 103 28 infections infection NNS cord-344988-09vpehvf 103 29 with with IN cord-344988-09vpehvf 103 30 Pneumocystis Pneumocystis NNP cord-344988-09vpehvf 103 31 jiroveci jiroveci NNP cord-344988-09vpehvf 103 32 ( ( -LRB- cord-344988-09vpehvf 103 33 formerly formerly RB cord-344988-09vpehvf 103 34 P. P. NNP cord-344988-09vpehvf 103 35 carinii carinii NN cord-344988-09vpehvf 103 36 ) ) -RRB- cord-344988-09vpehvf 103 37 and and CC cord-344988-09vpehvf 103 38 Candida Candida NNP cord-344988-09vpehvf 103 39 . . . cord-344988-09vpehvf 104 1 To to TO cord-344988-09vpehvf 104 2 antagonize antagonize VB cord-344988-09vpehvf 104 3 a a DT cord-344988-09vpehvf 104 4 loss loss NN cord-344988-09vpehvf 104 5 in in IN cord-344988-09vpehvf 104 6 TH TH NNP cord-344988-09vpehvf 104 7 cells cell NNS cord-344988-09vpehvf 104 8 , , , cord-344988-09vpehvf 104 9 zinc zinc NN cord-344988-09vpehvf 104 10 could could MD cord-344988-09vpehvf 104 11 either either CC cord-344988-09vpehvf 104 12 stimulate stimulate VB cord-344988-09vpehvf 104 13 T t NN cord-344988-09vpehvf 104 14 - - HYPH cord-344988-09vpehvf 104 15 lymphocyte lymphocyte NN cord-344988-09vpehvf 104 16 production production NN cord-344988-09vpehvf 104 17 or or CC cord-344988-09vpehvf 104 18 enhance enhance VB cord-344988-09vpehvf 104 19 their -PRON- PRP$ cord-344988-09vpehvf 104 20 survival survival NN cord-344988-09vpehvf 104 21 . . . cord-344988-09vpehvf 105 1 A a DT cord-344988-09vpehvf 105 2 reason reason NN cord-344988-09vpehvf 105 3 for for IN cord-344988-09vpehvf 105 4 the the DT cord-344988-09vpehvf 105 5 former former JJ cord-344988-09vpehvf 105 6 effect effect NN cord-344988-09vpehvf 105 7 may may MD cord-344988-09vpehvf 105 8 be be VB cord-344988-09vpehvf 105 9 an an DT cord-344988-09vpehvf 105 10 action action NN cord-344988-09vpehvf 105 11 of of IN cord-344988-09vpehvf 105 12 zinc zinc NN cord-344988-09vpehvf 105 13 through through IN cord-344988-09vpehvf 105 14 thymulin thymulin NNP cord-344988-09vpehvf 105 15 on on IN cord-344988-09vpehvf 105 16 the the DT cord-344988-09vpehvf 105 17 maturation maturation NN cord-344988-09vpehvf 105 18 of of IN cord-344988-09vpehvf 105 19 T t NN cord-344988-09vpehvf 105 20 cells cell NNS cord-344988-09vpehvf 105 21 . . . cord-344988-09vpehvf 106 1 Thymulin Thymulin NNP cord-344988-09vpehvf 106 2 is be VBZ cord-344988-09vpehvf 106 3 a a DT cord-344988-09vpehvf 106 4 zinc zinc NN cord-344988-09vpehvf 106 5 - - HYPH cord-344988-09vpehvf 106 6 dependent dependent JJ cord-344988-09vpehvf 106 7 nonapeptide nonapeptide NN cord-344988-09vpehvf 106 8 hormone hormone NN cord-344988-09vpehvf 106 9 [ [ -LRB- cord-344988-09vpehvf 106 10 26 26 CD cord-344988-09vpehvf 106 11 ] ] -RRB- cord-344988-09vpehvf 106 12 that that WDT cord-344988-09vpehvf 106 13 regulates regulate VBZ cord-344988-09vpehvf 106 14 the the DT cord-344988-09vpehvf 106 15 differentiation differentiation NN cord-344988-09vpehvf 106 16 of of IN cord-344988-09vpehvf 106 17 immature immature JJ cord-344988-09vpehvf 106 18 T t NN cord-344988-09vpehvf 106 19 cells cell NNS cord-344988-09vpehvf 106 20 in in IN cord-344988-09vpehvf 106 21 the the DT cord-344988-09vpehvf 106 22 thymus thymus NN cord-344988-09vpehvf 106 23 [ [ -LRB- cord-344988-09vpehvf 106 24 135 135 CD cord-344988-09vpehvf 106 25 ] ] -RRB- cord-344988-09vpehvf 106 26 and and CC cord-344988-09vpehvf 106 27 the the DT cord-344988-09vpehvf 106 28 function function NN cord-344988-09vpehvf 106 29 of of IN cord-344988-09vpehvf 106 30 mature mature JJ cord-344988-09vpehvf 106 31 T t NN cord-344988-09vpehvf 106 32 cells cell NNS cord-344988-09vpehvf 106 33 in in IN cord-344988-09vpehvf 106 34 the the DT cord-344988-09vpehvf 106 35 periphery periphery NN cord-344988-09vpehvf 106 36 [ [ -LRB- cord-344988-09vpehvf 106 37 24 24 CD cord-344988-09vpehvf 106 38 , , , cord-344988-09vpehvf 106 39 134 134 CD cord-344988-09vpehvf 106 40 ] ] -RRB- cord-344988-09vpehvf 106 41 . . . cord-344988-09vpehvf 107 1 On on IN cord-344988-09vpehvf 107 2 the the DT cord-344988-09vpehvf 107 3 other other JJ cord-344988-09vpehvf 107 4 hand hand NN cord-344988-09vpehvf 107 5 , , , cord-344988-09vpehvf 107 6 an an DT cord-344988-09vpehvf 107 7 antiapoptotic antiapoptotic JJ cord-344988-09vpehvf 107 8 action action NN cord-344988-09vpehvf 107 9 of of IN cord-344988-09vpehvf 107 10 zinc zinc NN cord-344988-09vpehvf 107 11 ions ion NNS cord-344988-09vpehvf 107 12 [ [ -LRB- cord-344988-09vpehvf 107 13 155 155 CD cord-344988-09vpehvf 107 14 ] ] -RRB- cord-344988-09vpehvf 107 15 at at IN cord-344988-09vpehvf 107 16 both both CC cord-344988-09vpehvf 107 17 the the DT cord-344988-09vpehvf 107 18 peripheral peripheral JJ cord-344988-09vpehvf 107 19 and and CC cord-344988-09vpehvf 107 20 thymic thymic JJ cord-344988-09vpehvf 107 21 level level NN cord-344988-09vpehvf 107 22 could could MD cord-344988-09vpehvf 107 23 result result VB cord-344988-09vpehvf 107 24 in in IN cord-344988-09vpehvf 107 25 an an DT cord-344988-09vpehvf 107 26 increase increase NN cord-344988-09vpehvf 107 27 in in IN cord-344988-09vpehvf 107 28 the the DT cord-344988-09vpehvf 107 29 number number NN cord-344988-09vpehvf 107 30 of of IN cord-344988-09vpehvf 107 31 TH TH NNP cord-344988-09vpehvf 107 32 cells cell NNS cord-344988-09vpehvf 107 33 . . . cord-344988-09vpehvf 108 1 It -PRON- PRP cord-344988-09vpehvf 108 2 is be VBZ cord-344988-09vpehvf 108 3 known know VBN cord-344988-09vpehvf 108 4 that that IN cord-344988-09vpehvf 108 5 zinc zinc NN cord-344988-09vpehvf 108 6 inhibits inhibit VBZ cord-344988-09vpehvf 108 7 caspases-3 caspases-3 NNP cord-344988-09vpehvf 108 8 , , , cord-344988-09vpehvf 108 9 -6 -6 NNP cord-344988-09vpehvf 108 10 , , , cord-344988-09vpehvf 108 11 and and CC cord-344988-09vpehvf 108 12 -9 -9 NNP cord-344988-09vpehvf 108 13 [ [ -LRB- cord-344988-09vpehvf 108 14 92 92 CD cord-344988-09vpehvf 108 15 , , , cord-344988-09vpehvf 108 16 111 111 CD cord-344988-09vpehvf 108 17 , , , cord-344988-09vpehvf 108 18 150 150 CD cord-344988-09vpehvf 108 19 , , , cord-344988-09vpehvf 108 20 172 172 CD cord-344988-09vpehvf 108 21 ] ] -RRB- cord-344988-09vpehvf 108 22 . . . cord-344988-09vpehvf 109 1 Moreover moreover RB cord-344988-09vpehvf 109 2 , , , cord-344988-09vpehvf 109 3 zinc zinc NN cord-344988-09vpehvf 109 4 can can MD cord-344988-09vpehvf 109 5 increase increase VB cord-344988-09vpehvf 109 6 the the DT cord-344988-09vpehvf 109 7 Bcl-2 Bcl-2 NNP cord-344988-09vpehvf 109 8 / / SYM cord-344988-09vpehvf 109 9 Bax Bax NNP cord-344988-09vpehvf 109 10 ratio ratio NN cord-344988-09vpehvf 109 11 , , , cord-344988-09vpehvf 109 12 thus thus RB cord-344988-09vpehvf 109 13 enhancing enhance VBG cord-344988-09vpehvf 109 14 the the DT cord-344988-09vpehvf 109 15 cells cell NNS cord-344988-09vpehvf 109 16 ' ' POS cord-344988-09vpehvf 109 17 resistance resistance NN cord-344988-09vpehvf 109 18 to to IN cord-344988-09vpehvf 109 19 apoptosis apoptosis NN cord-344988-09vpehvf 109 20 [ [ -LRB- cord-344988-09vpehvf 109 21 47 47 CD cord-344988-09vpehvf 109 22 ] ] -RRB- cord-344988-09vpehvf 109 23 . . . cord-344988-09vpehvf 110 1 Unfortunately unfortunately RB cord-344988-09vpehvf 110 2 , , , cord-344988-09vpehvf 110 3 the the DT cord-344988-09vpehvf 110 4 results result NNS cord-344988-09vpehvf 110 5 of of IN cord-344988-09vpehvf 110 6 the the DT cord-344988-09vpehvf 110 7 supplementation supplementation NN cord-344988-09vpehvf 110 8 trials trial NNS cord-344988-09vpehvf 110 9 are be VBP cord-344988-09vpehvf 110 10 not not RB cord-344988-09vpehvf 110 11 consistent consistent JJ cord-344988-09vpehvf 110 12 . . . cord-344988-09vpehvf 111 1 In in IN cord-344988-09vpehvf 111 2 contrast contrast NN cord-344988-09vpehvf 111 3 to to IN cord-344988-09vpehvf 111 4 the the DT cord-344988-09vpehvf 111 5 observations observation NNS cord-344988-09vpehvf 111 6 of of IN cord-344988-09vpehvf 111 7 Mocchegiani Mocchegiani NNP cord-344988-09vpehvf 111 8 et et NNP cord-344988-09vpehvf 111 9 al al NNP cord-344988-09vpehvf 111 10 . . . cord-344988-09vpehvf 112 1 [ [ -LRB- cord-344988-09vpehvf 112 2 95 95 CD cord-344988-09vpehvf 112 3 ] ] -RRB- cord-344988-09vpehvf 112 4 , , , cord-344988-09vpehvf 112 5 there there EX cord-344988-09vpehvf 112 6 was be VBD cord-344988-09vpehvf 112 7 no no DT cord-344988-09vpehvf 112 8 alteration alteration NN cord-344988-09vpehvf 112 9 of of IN cord-344988-09vpehvf 112 10 the the DT cord-344988-09vpehvf 112 11 CD4 CD4 NNP cord-344988-09vpehvf 112 12 / / SYM cord-344988-09vpehvf 112 13 CD8 CD8 NNP cord-344988-09vpehvf 112 14 ratio ratio NN cord-344988-09vpehvf 112 15 in in IN cord-344988-09vpehvf 112 16 the the DT cord-344988-09vpehvf 112 17 initial initial JJ cord-344988-09vpehvf 112 18 study study NN cord-344988-09vpehvf 112 19 [ [ -LRB- cord-344988-09vpehvf 112 20 176 176 CD cord-344988-09vpehvf 112 21 ] ] -RRB- cord-344988-09vpehvf 112 22 and and CC cord-344988-09vpehvf 112 23 several several JJ cord-344988-09vpehvf 112 24 recent recent JJ cord-344988-09vpehvf 112 25 papers paper NNS cord-344988-09vpehvf 112 26 were be VBD cord-344988-09vpehvf 112 27 unable unable JJ cord-344988-09vpehvf 112 28 to to TO cord-344988-09vpehvf 112 29 find find VB cord-344988-09vpehvf 112 30 effects effect NNS cord-344988-09vpehvf 112 31 of of IN cord-344988-09vpehvf 112 32 oral oral JJ cord-344988-09vpehvf 112 33 zinc zinc NN cord-344988-09vpehvf 112 34 on on IN cord-344988-09vpehvf 112 35 HIV-1 HIV-1 NNP cord-344988-09vpehvf 112 36 viral viral JJ cord-344988-09vpehvf 112 37 load load NN cord-344988-09vpehvf 112 38 , , , cord-344988-09vpehvf 112 39 immune immune JJ cord-344988-09vpehvf 112 40 response response NN cord-344988-09vpehvf 112 41 to to IN cord-344988-09vpehvf 112 42 tuberculosis tuberculosis NN cord-344988-09vpehvf 112 43 , , , cord-344988-09vpehvf 112 44 lymphocyte lymphocyte NN cord-344988-09vpehvf 112 45 subsets subset NNS cord-344988-09vpehvf 112 46 , , , cord-344988-09vpehvf 112 47 CD4 CD4 NNP cord-344988-09vpehvf 112 48 + + CC cord-344988-09vpehvf 112 49 , , , cord-344988-09vpehvf 112 50 CD8 CD8 NNP cord-344988-09vpehvf 112 51 + + CC cord-344988-09vpehvf 112 52 , , , cord-344988-09vpehvf 112 53 and and CC cord-344988-09vpehvf 112 54 CD3 CD3 NNP cord-344988-09vpehvf 112 55 + + CC cord-344988-09vpehvf 112 56 cell cell NN cord-344988-09vpehvf 112 57 counts count NNS cord-344988-09vpehvf 112 58 , , , cord-344988-09vpehvf 112 59 or or CC cord-344988-09vpehvf 112 60 antibody antibody NN cord-344988-09vpehvf 112 61 response response NN cord-344988-09vpehvf 112 62 to to IN cord-344988-09vpehvf 112 63 a a DT cord-344988-09vpehvf 112 64 pneumococcal pneumococcal JJ cord-344988-09vpehvf 112 65 conjugate conjugate NN cord-344988-09vpehvf 112 66 vaccine vaccine NN cord-344988-09vpehvf 112 67 [ [ -LRB- cord-344988-09vpehvf 112 68 16 16 CD cord-344988-09vpehvf 112 69 , , , cord-344988-09vpehvf 112 70 27 27 CD cord-344988-09vpehvf 112 71 , , , cord-344988-09vpehvf 112 72 40 40 CD cord-344988-09vpehvf 112 73 , , , cord-344988-09vpehvf 112 74 54 54 CD cord-344988-09vpehvf 112 75 , , , cord-344988-09vpehvf 112 76 163 163 CD cord-344988-09vpehvf 112 77 ] ] -RRB- cord-344988-09vpehvf 112 78 . . . cord-344988-09vpehvf 113 1 In in IN cord-344988-09vpehvf 113 2 addition addition NN cord-344988-09vpehvf 113 3 , , , cord-344988-09vpehvf 113 4 when when WRB cord-344988-09vpehvf 113 5 Fawzi Fawzi NNP cord-344988-09vpehvf 113 6 et et NNP cord-344988-09vpehvf 113 7 al al NNP cord-344988-09vpehvf 113 8 . . . cord-344988-09vpehvf 114 1 [ [ -LRB- cord-344988-09vpehvf 114 2 40 40 CD cord-344988-09vpehvf 114 3 ] ] -RRB- cord-344988-09vpehvf 114 4 investigated investigate VBD cord-344988-09vpehvf 114 5 the the DT cord-344988-09vpehvf 114 6 effects effect NNS cord-344988-09vpehvf 114 7 of of IN cord-344988-09vpehvf 114 8 zinc zinc NN cord-344988-09vpehvf 114 9 supplementation supplementation NN cord-344988-09vpehvf 114 10 on on IN cord-344988-09vpehvf 114 11 pregnant pregnant JJ cord-344988-09vpehvf 114 12 HIV HIV NNP cord-344988-09vpehvf 114 13 - - HYPH cord-344988-09vpehvf 114 14 positive positive JJ cord-344988-09vpehvf 114 15 women woman NNS cord-344988-09vpehvf 114 16 , , , cord-344988-09vpehvf 114 17 zinc zinc NN cord-344988-09vpehvf 114 18 had have VBD cord-344988-09vpehvf 114 19 no no DT cord-344988-09vpehvf 114 20 effect effect NN cord-344988-09vpehvf 114 21 on on IN cord-344988-09vpehvf 114 22 pregnancy pregnancy NN cord-344988-09vpehvf 114 23 outcome outcome NN cord-344988-09vpehvf 114 24 , , , cord-344988-09vpehvf 114 25 but but CC cord-344988-09vpehvf 114 26 the the DT cord-344988-09vpehvf 114 27 authors author NNS cord-344988-09vpehvf 114 28 reported report VBD cord-344988-09vpehvf 114 29 lower low JJR cord-344988-09vpehvf 114 30 increases increase NNS cord-344988-09vpehvf 114 31 in in IN cord-344988-09vpehvf 114 32 hemoglobin hemoglobin NN cord-344988-09vpehvf 114 33 , , , cord-344988-09vpehvf 114 34 red red JJ cord-344988-09vpehvf 114 35 blood blood NN cord-344988-09vpehvf 114 36 cell cell NN cord-344988-09vpehvf 114 37 count count NN cord-344988-09vpehvf 114 38 , , , cord-344988-09vpehvf 114 39 and and CC cord-344988-09vpehvf 114 40 packed pack VBN cord-344988-09vpehvf 114 41 cell cell NN cord-344988-09vpehvf 114 42 volume volume NN cord-344988-09vpehvf 114 43 after after IN cord-344988-09vpehvf 114 44 the the DT cord-344988-09vpehvf 114 45 women woman NNS cord-344988-09vpehvf 114 46 had have VBD cord-344988-09vpehvf 114 47 given give VBN cord-344988-09vpehvf 114 48 birth birth NN cord-344988-09vpehvf 114 49 . . . cord-344988-09vpehvf 115 1 To to TO cord-344988-09vpehvf 115 2 make make VB cord-344988-09vpehvf 115 3 matters matter NNS cord-344988-09vpehvf 115 4 worse bad JJR cord-344988-09vpehvf 115 5 , , , cord-344988-09vpehvf 115 6 two two CD cord-344988-09vpehvf 115 7 studies study NNS cord-344988-09vpehvf 115 8 by by IN cord-344988-09vpehvf 115 9 Tang Tang NNP cord-344988-09vpehvf 115 10 et et NNP cord-344988-09vpehvf 115 11 al al NNP cord-344988-09vpehvf 115 12 . . . cord-344988-09vpehvf 116 1 [ [ -LRB- cord-344988-09vpehvf 116 2 153 153 CD cord-344988-09vpehvf 116 3 , , , cord-344988-09vpehvf 116 4 154 154 CD cord-344988-09vpehvf 116 5 ] ] -RRB- cord-344988-09vpehvf 116 6 indicated indicate VBD cord-344988-09vpehvf 116 7 an an DT cord-344988-09vpehvf 116 8 increased increase VBN cord-344988-09vpehvf 116 9 risk risk NN cord-344988-09vpehvf 116 10 for for IN cord-344988-09vpehvf 116 11 the the DT cord-344988-09vpehvf 116 12 progression progression NN cord-344988-09vpehvf 116 13 to to IN cord-344988-09vpehvf 116 14 AIDS AIDS NNP cord-344988-09vpehvf 116 15 and and CC cord-344988-09vpehvf 116 16 a a DT cord-344988-09vpehvf 116 17 lower low JJR cord-344988-09vpehvf 116 18 survival survival NN cord-344988-09vpehvf 116 19 after after IN cord-344988-09vpehvf 116 20 zinc zinc NN cord-344988-09vpehvf 116 21 intake intake NN cord-344988-09vpehvf 116 22 by by IN cord-344988-09vpehvf 116 23 HIV HIV NNP cord-344988-09vpehvf 116 24 - - HYPH cord-344988-09vpehvf 116 25 positive positive JJ cord-344988-09vpehvf 116 26 individuals individual NNS cord-344988-09vpehvf 116 27 . . . cord-344988-09vpehvf 117 1 One one CD cord-344988-09vpehvf 117 2 explanation explanation NN cord-344988-09vpehvf 117 3 for for IN cord-344988-09vpehvf 117 4 these these DT cord-344988-09vpehvf 117 5 contradictory contradictory JJ cord-344988-09vpehvf 117 6 results result NNS cord-344988-09vpehvf 117 7 may may MD cord-344988-09vpehvf 117 8 be be VB cord-344988-09vpehvf 117 9 a a DT cord-344988-09vpehvf 117 10 different different JJ cord-344988-09vpehvf 117 11 zinc zinc NN cord-344988-09vpehvf 117 12 status status NN cord-344988-09vpehvf 117 13 of of IN cord-344988-09vpehvf 117 14 the the DT cord-344988-09vpehvf 117 15 patients patient NNS cord-344988-09vpehvf 117 16 . . . cord-344988-09vpehvf 118 1 While while IN cord-344988-09vpehvf 118 2 moderate moderate JJ cord-344988-09vpehvf 118 3 zinc zinc NN cord-344988-09vpehvf 118 4 supplementation supplementation NN cord-344988-09vpehvf 118 5 to to IN cord-344988-09vpehvf 118 6 zinc zinc NN cord-344988-09vpehvf 118 7 - - HYPH cord-344988-09vpehvf 118 8 deficient deficient JJ cord-344988-09vpehvf 118 9 subjects subject NNS cord-344988-09vpehvf 118 10 can can MD cord-344988-09vpehvf 118 11 advance advance VB cord-344988-09vpehvf 118 12 their -PRON- PRP$ cord-344988-09vpehvf 118 13 immune immune JJ cord-344988-09vpehvf 118 14 responses response NNS cord-344988-09vpehvf 118 15 , , , cord-344988-09vpehvf 118 16 it -PRON- PRP cord-344988-09vpehvf 118 17 may may MD cord-344988-09vpehvf 118 18 have have VB cord-344988-09vpehvf 118 19 harmful harmful JJ cord-344988-09vpehvf 118 20 effects effect NNS cord-344988-09vpehvf 118 21 when when WRB cord-344988-09vpehvf 118 22 given give VBN cord-344988-09vpehvf 118 23 to to IN cord-344988-09vpehvf 118 24 zinc zinc NN cord-344988-09vpehvf 118 25 - - HYPH cord-344988-09vpehvf 118 26 sufficient sufficient JJ cord-344988-09vpehvf 118 27 ones one NNS cord-344988-09vpehvf 118 28 . . . cord-344988-09vpehvf 119 1 Zinc zinc NN cord-344988-09vpehvf 119 2 deficiency deficiency NN cord-344988-09vpehvf 119 3 is be VBZ cord-344988-09vpehvf 119 4 frequent frequent JJ cord-344988-09vpehvf 119 5 in in IN cord-344988-09vpehvf 119 6 patients patient NNS cord-344988-09vpehvf 119 7 with with IN cord-344988-09vpehvf 119 8 AIDS AIDS NNP cord-344988-09vpehvf 119 9 without without IN cord-344988-09vpehvf 119 10 treatment treatment NN cord-344988-09vpehvf 119 11 ; ; : cord-344988-09vpehvf 119 12 however however RB cord-344988-09vpehvf 119 13 , , , cord-344988-09vpehvf 119 14 anti anti JJ cord-344988-09vpehvf 119 15 - - JJ cord-344988-09vpehvf 119 16 retroviral retroviral JJ cord-344988-09vpehvf 119 17 therapy therapy NN cord-344988-09vpehvf 119 18 has have VBZ cord-344988-09vpehvf 119 19 been be VBN cord-344988-09vpehvf 119 20 shown show VBN cord-344988-09vpehvf 119 21 to to TO cord-344988-09vpehvf 119 22 counteract counteract VB cord-344988-09vpehvf 119 23 the the DT cord-344988-09vpehvf 119 24 zinc zinc NN cord-344988-09vpehvf 119 25 deficiency deficiency NN cord-344988-09vpehvf 119 26 [ [ -LRB- cord-344988-09vpehvf 119 27 133 133 CD cord-344988-09vpehvf 119 28 ] ] -RRB- cord-344988-09vpehvf 119 29 . . . cord-344988-09vpehvf 120 1 Hence hence RB cord-344988-09vpehvf 120 2 , , , cord-344988-09vpehvf 120 3 zinc zinc NN cord-344988-09vpehvf 120 4 supplementation supplementation NN cord-344988-09vpehvf 120 5 should should MD cord-344988-09vpehvf 120 6 be be VB cord-344988-09vpehvf 120 7 seen see VBN cord-344988-09vpehvf 120 8 as as IN cord-344988-09vpehvf 120 9 a a DT cord-344988-09vpehvf 120 10 potential potential JJ cord-344988-09vpehvf 120 11 hazard hazard NN cord-344988-09vpehvf 120 12 to to IN cord-344988-09vpehvf 120 13 these these DT cord-344988-09vpehvf 120 14 patients patient NNS cord-344988-09vpehvf 120 15 and and CC cord-344988-09vpehvf 120 16 be be VB cord-344988-09vpehvf 120 17 strictly strictly RB cord-344988-09vpehvf 120 18 limited limit VBN cord-344988-09vpehvf 120 19 to to IN cord-344988-09vpehvf 120 20 individuals individual NNS cord-344988-09vpehvf 120 21 with with IN cord-344988-09vpehvf 120 22 documented documented JJ cord-344988-09vpehvf 120 23 zinc zinc NN cord-344988-09vpehvf 120 24 deficiency deficiency NN cord-344988-09vpehvf 120 25 . . . cord-344988-09vpehvf 121 1 Finally finally RB cord-344988-09vpehvf 121 2 , , , cord-344988-09vpehvf 121 3 several several JJ cord-344988-09vpehvf 121 4 studies study NNS cord-344988-09vpehvf 121 5 have have VBP cord-344988-09vpehvf 121 6 investigated investigate VBN cord-344988-09vpehvf 121 7 the the DT cord-344988-09vpehvf 121 8 effect effect NN cord-344988-09vpehvf 121 9 of of IN cord-344988-09vpehvf 121 10 zinc zinc NN cord-344988-09vpehvf 121 11 supplementation supplementation NN cord-344988-09vpehvf 121 12 on on IN cord-344988-09vpehvf 121 13 hepatitis hepatitis NNP cord-344988-09vpehvf 121 14 C C NNP cord-344988-09vpehvf 121 15 , , , cord-344988-09vpehvf 121 16 which which WDT cord-344988-09vpehvf 121 17 is be VBZ cord-344988-09vpehvf 121 18 induced induce VBN cord-344988-09vpehvf 121 19 by by IN cord-344988-09vpehvf 121 20 an an DT cord-344988-09vpehvf 121 21 infection infection NN cord-344988-09vpehvf 121 22 with with IN cord-344988-09vpehvf 121 23 the the DT cord-344988-09vpehvf 121 24 hepatitis hepatitis NN cord-344988-09vpehvf 121 25 C C NNP cord-344988-09vpehvf 121 26 virus virus NN cord-344988-09vpehvf 121 27 ( ( -LRB- cord-344988-09vpehvf 121 28 HCV HCV NNP cord-344988-09vpehvf 121 29 ) ) -RRB- cord-344988-09vpehvf 121 30 . . . cord-344988-09vpehvf 122 1 After after IN cord-344988-09vpehvf 122 2 zinc zinc NN cord-344988-09vpehvf 122 3 treatment treatment NN cord-344988-09vpehvf 122 4 , , , cord-344988-09vpehvf 122 5 decreases decrease VBZ cord-344988-09vpehvf 122 6 in in IN cord-344988-09vpehvf 122 7 the the DT cord-344988-09vpehvf 122 8 incidence incidence NN cord-344988-09vpehvf 122 9 of of IN cord-344988-09vpehvf 122 10 gastrointestinal gastrointestinal JJ cord-344988-09vpehvf 122 11 disturbances disturbance NNS cord-344988-09vpehvf 122 12 , , , cord-344988-09vpehvf 122 13 body body NN cord-344988-09vpehvf 122 14 weight weight NN cord-344988-09vpehvf 122 15 loss loss NN cord-344988-09vpehvf 122 16 , , , cord-344988-09vpehvf 122 17 and and CC cord-344988-09vpehvf 122 18 mild mild JJ cord-344988-09vpehvf 122 19 anemia anemia NN cord-344988-09vpehvf 122 20 were be VBD cord-344988-09vpehvf 122 21 found find VBN cord-344988-09vpehvf 122 22 in in IN cord-344988-09vpehvf 122 23 patients patient NNS cord-344988-09vpehvf 122 24 with with IN cord-344988-09vpehvf 122 25 chronic chronic JJ cord-344988-09vpehvf 122 26 hepatitis hepatitis NN cord-344988-09vpehvf 122 27 C c NN cord-344988-09vpehvf 122 28 [ [ -LRB- cord-344988-09vpehvf 122 29 72 72 CD cord-344988-09vpehvf 122 30 ] ] -RRB- cord-344988-09vpehvf 122 31 . . . cord-344988-09vpehvf 123 1 In in IN cord-344988-09vpehvf 123 2 addition addition NN cord-344988-09vpehvf 123 3 , , , cord-344988-09vpehvf 123 4 zinc zinc NN cord-344988-09vpehvf 123 5 given give VBN cord-344988-09vpehvf 123 6 in in IN cord-344988-09vpehvf 123 7 combination combination NN cord-344988-09vpehvf 123 8 with with IN cord-344988-09vpehvf 123 9 IFN IFN NNP cord-344988-09vpehvf 123 10 - - HYPH cord-344988-09vpehvf 123 11 α α NNP cord-344988-09vpehvf 123 12 was be VBD cord-344988-09vpehvf 123 13 more more RBR cord-344988-09vpehvf 123 14 effective effective JJ cord-344988-09vpehvf 123 15 against against IN cord-344988-09vpehvf 123 16 chronic chronic JJ cord-344988-09vpehvf 123 17 hepatitis hepatitis NN cord-344988-09vpehvf 123 18 C c NN cord-344988-09vpehvf 123 19 than than IN cord-344988-09vpehvf 123 20 a a DT cord-344988-09vpehvf 123 21 therapy therapy NN cord-344988-09vpehvf 123 22 with with IN cord-344988-09vpehvf 123 23 IFN IFN NNP cord-344988-09vpehvf 123 24 - - HYPH cord-344988-09vpehvf 123 25 α α NNP cord-344988-09vpehvf 123 26 alone alone RB cord-344988-09vpehvf 123 27 [ [ -LRB- cord-344988-09vpehvf 123 28 152 152 CD cord-344988-09vpehvf 123 29 ] ] -RRB- cord-344988-09vpehvf 123 30 . . . cord-344988-09vpehvf 124 1 In in IN cord-344988-09vpehvf 124 2 addition addition NN cord-344988-09vpehvf 124 3 to to IN cord-344988-09vpehvf 124 4 the the DT cord-344988-09vpehvf 124 5 effects effect NNS cord-344988-09vpehvf 124 6 of of IN cord-344988-09vpehvf 124 7 zinc zinc NN cord-344988-09vpehvf 124 8 on on IN cord-344988-09vpehvf 124 9 immune immune JJ cord-344988-09vpehvf 124 10 function function NN cord-344988-09vpehvf 124 11 and and CC cord-344988-09vpehvf 124 12 antiviral antiviral JJ cord-344988-09vpehvf 124 13 defense defense NN cord-344988-09vpehvf 124 14 discussed discuss VBN cord-344988-09vpehvf 124 15 above above RB cord-344988-09vpehvf 124 16 , , , cord-344988-09vpehvf 124 17 its -PRON- PRP$ cord-344988-09vpehvf 124 18 role role NN cord-344988-09vpehvf 124 19 as as IN cord-344988-09vpehvf 124 20 an an DT cord-344988-09vpehvf 124 21 antioxidant antioxidant NN cord-344988-09vpehvf 124 22 may may MD cord-344988-09vpehvf 124 23 be be VB cord-344988-09vpehvf 124 24 important important JJ cord-344988-09vpehvf 124 25 in in IN cord-344988-09vpehvf 124 26 hepatitis hepatitis NN cord-344988-09vpehvf 124 27 . . . cord-344988-09vpehvf 125 1 Oxidative oxidative JJ cord-344988-09vpehvf 125 2 stress stress NN cord-344988-09vpehvf 125 3 is be VBZ cord-344988-09vpehvf 125 4 a a DT cord-344988-09vpehvf 125 5 major major JJ cord-344988-09vpehvf 125 6 contributor contributor NN cord-344988-09vpehvf 125 7 to to IN cord-344988-09vpehvf 125 8 cellular cellular JJ cord-344988-09vpehvf 125 9 damage damage NN cord-344988-09vpehvf 125 10 during during IN cord-344988-09vpehvf 125 11 viral viral JJ cord-344988-09vpehvf 125 12 hepatitis hepatitis NN cord-344988-09vpehvf 125 13 [ [ -LRB- cord-344988-09vpehvf 125 14 149 149 CD cord-344988-09vpehvf 125 15 ] ] -RRB- cord-344988-09vpehvf 125 16 . . . cord-344988-09vpehvf 126 1 In in IN cord-344988-09vpehvf 126 2 mice mouse NNS cord-344988-09vpehvf 126 3 it -PRON- PRP cord-344988-09vpehvf 126 4 was be VBD cord-344988-09vpehvf 126 5 shown show VBN cord-344988-09vpehvf 126 6 that that IN cord-344988-09vpehvf 126 7 zinc zinc NN cord-344988-09vpehvf 126 8 enhances enhance VBZ cord-344988-09vpehvf 126 9 the the DT cord-344988-09vpehvf 126 10 expression expression NN cord-344988-09vpehvf 126 11 of of IN cord-344988-09vpehvf 126 12 MT MT NNP cord-344988-09vpehvf 126 13 in in IN cord-344988-09vpehvf 126 14 liver liver NN cord-344988-09vpehvf 126 15 tissues tissue NNS cord-344988-09vpehvf 126 16 [ [ -LRB- cord-344988-09vpehvf 126 17 34 34 CD cord-344988-09vpehvf 126 18 ] ] -RRB- cord-344988-09vpehvf 126 19 , , , cord-344988-09vpehvf 126 20 which which WDT cord-344988-09vpehvf 126 21 can can MD cord-344988-09vpehvf 126 22 function function VB cord-344988-09vpehvf 126 23 as as IN cord-344988-09vpehvf 126 24 a a DT cord-344988-09vpehvf 126 25 free free JJ cord-344988-09vpehvf 126 26 radical radical JJ cord-344988-09vpehvf 126 27 scavenger scavenger NN cord-344988-09vpehvf 126 28 [ [ -LRB- cord-344988-09vpehvf 126 29 140 140 CD cord-344988-09vpehvf 126 30 , , , cord-344988-09vpehvf 126 31 162 162 CD cord-344988-09vpehvf 126 32 ] ] -RRB- cord-344988-09vpehvf 126 33 and and CC cord-344988-09vpehvf 126 34 may may MD cord-344988-09vpehvf 126 35 prevent prevent VB cord-344988-09vpehvf 126 36 oxidative oxidative JJ cord-344988-09vpehvf 126 37 damage damage NN cord-344988-09vpehvf 126 38 to to IN cord-344988-09vpehvf 126 39 liver liver NN cord-344988-09vpehvf 126 40 tissue tissue NN cord-344988-09vpehvf 126 41 [ [ -LRB- cord-344988-09vpehvf 126 42 86 86 CD cord-344988-09vpehvf 126 43 ] ] -RRB- cord-344988-09vpehvf 126 44 . . . cord-344988-09vpehvf 127 1 Several several JJ cord-344988-09vpehvf 127 2 in in IN cord-344988-09vpehvf 127 3 vitro vitro FW cord-344988-09vpehvf 127 4 studies study NNS cord-344988-09vpehvf 127 5 indicate indicate VBP cord-344988-09vpehvf 127 6 that that IN cord-344988-09vpehvf 127 7 zinc zinc NN cord-344988-09vpehvf 127 8 may may MD cord-344988-09vpehvf 127 9 be be VB cord-344988-09vpehvf 127 10 able able JJ cord-344988-09vpehvf 127 11 to to TO cord-344988-09vpehvf 127 12 inhibit inhibit VB cord-344988-09vpehvf 127 13 viral viral JJ cord-344988-09vpehvf 127 14 replication replication NN cord-344988-09vpehvf 127 15 of of IN cord-344988-09vpehvf 127 16 HCV HCV NNP cord-344988-09vpehvf 127 17 [ [ -LRB- cord-344988-09vpehvf 127 18 174 174 CD cord-344988-09vpehvf 127 19 ] ] -RRB- cord-344988-09vpehvf 127 20 , , , cord-344988-09vpehvf 127 21 but but CC cord-344988-09vpehvf 127 22 also also RB cord-344988-09vpehvf 127 23 herpes herpes NN cord-344988-09vpehvf 127 24 simplex simplex NN cord-344988-09vpehvf 127 25 virus virus NN cord-344988-09vpehvf 127 26 [ [ -LRB- cord-344988-09vpehvf 127 27 77 77 CD cord-344988-09vpehvf 127 28 ] ] -RRB- cord-344988-09vpehvf 127 29 and and CC cord-344988-09vpehvf 127 30 rhinovirus rhinovirus NN cord-344988-09vpehvf 127 31 [ [ -LRB- cord-344988-09vpehvf 127 32 74 74 CD cord-344988-09vpehvf 127 33 ] ] -RRB- cord-344988-09vpehvf 127 34 , , , cord-344988-09vpehvf 127 35 all all DT cord-344988-09vpehvf 127 36 at at IN cord-344988-09vpehvf 127 37 concentrations concentration NNS cord-344988-09vpehvf 127 38 of of IN cord-344988-09vpehvf 127 39 100 100 CD cord-344988-09vpehvf 127 40 µM µm CD cord-344988-09vpehvf 127 41 zinc zinc NN cord-344988-09vpehvf 127 42 ions ion NNS cord-344988-09vpehvf 127 43 in in IN cord-344988-09vpehvf 127 44 the the DT cord-344988-09vpehvf 127 45 culture culture NN cord-344988-09vpehvf 127 46 medium medium NN cord-344988-09vpehvf 127 47 . . . cord-344988-09vpehvf 128 1 For for IN cord-344988-09vpehvf 128 2 HIV HIV NNP cord-344988-09vpehvf 128 3 , , , cord-344988-09vpehvf 128 4 a a DT cord-344988-09vpehvf 128 5 concentration concentration NN cord-344988-09vpehvf 128 6 of of IN cord-344988-09vpehvf 128 7 100 100 CD cord-344988-09vpehvf 128 8 µg µg NN cord-344988-09vpehvf 128 9 / / SYM cord-344988-09vpehvf 128 10 ml ml NN cord-344988-09vpehvf 128 11 ( ( -LRB- cord-344988-09vpehvf 128 12 ~1.5 ~1.5 CD cord-344988-09vpehvf 128 13 mM mm CD cord-344988-09vpehvf 128 14 ) ) -RRB- cord-344988-09vpehvf 128 15 was be VBD cord-344988-09vpehvf 128 16 effective effective JJ cord-344988-09vpehvf 128 17 [ [ -LRB- cord-344988-09vpehvf 128 18 60 60 CD cord-344988-09vpehvf 128 19 ] ] -RRB- cord-344988-09vpehvf 128 20 . . . cord-344988-09vpehvf 129 1 All all PDT cord-344988-09vpehvf 129 2 these these DT cord-344988-09vpehvf 129 3 amounts amount NNS cord-344988-09vpehvf 129 4 seem seem VBP cord-344988-09vpehvf 129 5 to to TO cord-344988-09vpehvf 129 6 be be VB cord-344988-09vpehvf 129 7 relatively relatively RB cord-344988-09vpehvf 129 8 high high JJ cord-344988-09vpehvf 129 9 . . . cord-344988-09vpehvf 130 1 Hence hence RB cord-344988-09vpehvf 130 2 , , , cord-344988-09vpehvf 130 3 the the DT cord-344988-09vpehvf 130 4 in in IN cord-344988-09vpehvf 130 5 vivo vivo NN cord-344988-09vpehvf 130 6 relevance relevance NN cord-344988-09vpehvf 130 7 of of IN cord-344988-09vpehvf 130 8 an an DT cord-344988-09vpehvf 130 9 inhibition inhibition NN cord-344988-09vpehvf 130 10 of of IN cord-344988-09vpehvf 130 11 viral viral JJ cord-344988-09vpehvf 130 12 replication replication NN cord-344988-09vpehvf 130 13 as as IN cord-344988-09vpehvf 130 14 a a DT cord-344988-09vpehvf 130 15 mechanism mechanism NN cord-344988-09vpehvf 130 16 for for IN cord-344988-09vpehvf 130 17 antiviral antiviral JJ cord-344988-09vpehvf 130 18 actions action NNS cord-344988-09vpehvf 130 19 of of IN cord-344988-09vpehvf 130 20 zinc zinc NN cord-344988-09vpehvf 130 21 in in IN cord-344988-09vpehvf 130 22 humans human NNS cord-344988-09vpehvf 130 23 remains remain VBZ cord-344988-09vpehvf 130 24 to to TO cord-344988-09vpehvf 130 25 be be VB cord-344988-09vpehvf 130 26 demonstrated demonstrate VBN cord-344988-09vpehvf 130 27 . . . cord-344988-09vpehvf 131 1 Different different JJ cord-344988-09vpehvf 131 2 zinc zinc NN cord-344988-09vpehvf 131 3 supplementation supplementation NN cord-344988-09vpehvf 131 4 studies study NNS cord-344988-09vpehvf 131 5 dealing deal VBG cord-344988-09vpehvf 131 6 with with IN cord-344988-09vpehvf 131 7 diseases disease NNS cord-344988-09vpehvf 131 8 caused cause VBN cord-344988-09vpehvf 131 9 by by IN cord-344988-09vpehvf 131 10 bacterial bacterial JJ cord-344988-09vpehvf 131 11 pathogens pathogen NNS cord-344988-09vpehvf 131 12 are be VBP cord-344988-09vpehvf 131 13 listed list VBN cord-344988-09vpehvf 131 14 in in IN cord-344988-09vpehvf 131 15 Table Table NNP cord-344988-09vpehvf 131 16 4 4 CD cord-344988-09vpehvf 131 17 . . . cord-344988-09vpehvf 132 1 Diarrhea diarrhea NN cord-344988-09vpehvf 132 2 can can MD cord-344988-09vpehvf 132 3 be be VB cord-344988-09vpehvf 132 4 either either CC cord-344988-09vpehvf 132 5 of of IN cord-344988-09vpehvf 132 6 viral viral JJ cord-344988-09vpehvf 132 7 or or CC cord-344988-09vpehvf 132 8 bacterial bacterial JJ cord-344988-09vpehvf 132 9 origin origin NN cord-344988-09vpehvf 132 10 , , , cord-344988-09vpehvf 132 11 but but CC cord-344988-09vpehvf 132 12 because because IN cord-344988-09vpehvf 132 13 there there EX cord-344988-09vpehvf 132 14 seem seem VBP cord-344988-09vpehvf 132 15 to to TO cord-344988-09vpehvf 132 16 be be VB cord-344988-09vpehvf 132 17 no no DT cord-344988-09vpehvf 132 18 obvious obvious JJ cord-344988-09vpehvf 132 19 differences difference NNS cord-344988-09vpehvf 132 20 in in IN cord-344988-09vpehvf 132 21 the the DT cord-344988-09vpehvf 132 22 effects effect NNS cord-344988-09vpehvf 132 23 of of IN cord-344988-09vpehvf 132 24 zinc zinc NN cord-344988-09vpehvf 132 25 treatment treatment NN cord-344988-09vpehvf 132 26 , , , cord-344988-09vpehvf 132 27 we -PRON- PRP cord-344988-09vpehvf 132 28 will will MD cord-344988-09vpehvf 132 29 discuss discuss VB cord-344988-09vpehvf 132 30 all all DT cord-344988-09vpehvf 132 31 forms form NNS cord-344988-09vpehvf 132 32 together together RB cord-344988-09vpehvf 132 33 in in IN cord-344988-09vpehvf 132 34 this this DT cord-344988-09vpehvf 132 35 paragraph paragraph NN cord-344988-09vpehvf 132 36 . . . cord-344988-09vpehvf 133 1 Diarrhea diarrhea NN cord-344988-09vpehvf 133 2 is be VBZ cord-344988-09vpehvf 133 3 a a DT cord-344988-09vpehvf 133 4 target target NN cord-344988-09vpehvf 133 5 for for IN cord-344988-09vpehvf 133 6 successful successful JJ cord-344988-09vpehvf 133 7 zinc zinc NN cord-344988-09vpehvf 133 8 treatment treatment NN cord-344988-09vpehvf 133 9 . . . cord-344988-09vpehvf 134 1 This this DT cord-344988-09vpehvf 134 2 has have VBZ cord-344988-09vpehvf 134 3 been be VBN cord-344988-09vpehvf 134 4 extensively extensively RB cord-344988-09vpehvf 134 5 studied study VBN cord-344988-09vpehvf 134 6 , , , cord-344988-09vpehvf 134 7 and and CC cord-344988-09vpehvf 134 8 the the DT cord-344988-09vpehvf 134 9 results result NNS cord-344988-09vpehvf 134 10 have have VBP cord-344988-09vpehvf 134 11 already already RB cord-344988-09vpehvf 134 12 been be VBN cord-344988-09vpehvf 134 13 summarized summarize VBN cord-344988-09vpehvf 134 14 in in IN cord-344988-09vpehvf 134 15 detail detail NN cord-344988-09vpehvf 134 16 , , , cord-344988-09vpehvf 134 17 showing show VBG cord-344988-09vpehvf 134 18 that that IN cord-344988-09vpehvf 134 19 zinc zinc NN cord-344988-09vpehvf 134 20 can can MD cord-344988-09vpehvf 134 21 reduce reduce VB cord-344988-09vpehvf 134 22 the the DT cord-344988-09vpehvf 134 23 duration duration NN cord-344988-09vpehvf 134 24 , , , cord-344988-09vpehvf 134 25 sever sever NN cord-344988-09vpehvf 134 26 - - HYPH cord-344988-09vpehvf 134 27 ity ity NN cord-344988-09vpehvf 134 28 , , , cord-344988-09vpehvf 134 29 and and CC cord-344988-09vpehvf 134 30 incidence incidence NN cord-344988-09vpehvf 134 31 of of IN cord-344988-09vpehvf 134 32 diarrhea diarrhea NN cord-344988-09vpehvf 134 33 [ [ -LRB- cord-344988-09vpehvf 134 34 41 41 CD cord-344988-09vpehvf 134 35 , , , cord-344988-09vpehvf 134 36 63 63 CD cord-344988-09vpehvf 134 37 ] ] -RRB- cord-344988-09vpehvf 134 38 . . . cord-344988-09vpehvf 135 1 Two two CD cord-344988-09vpehvf 135 2 pooled pool VBN cord-344988-09vpehvf 135 3 analyses analysis NNS cord-344988-09vpehvf 135 4 were be VBD cord-344988-09vpehvf 135 5 conducted conduct VBN cord-344988-09vpehvf 135 6 by by IN cord-344988-09vpehvf 135 7 the the DT cord-344988-09vpehvf 135 8 Zinc Zinc NNP cord-344988-09vpehvf 135 9 Investigators Investigators NNPS cord-344988-09vpehvf 135 10 ' ' POS cord-344988-09vpehvf 135 11 Collaborative Collaborative NNP cord-344988-09vpehvf 135 12 Study Study NNP cord-344988-09vpehvf 135 13 Group Group NNP cord-344988-09vpehvf 135 14 assessing assess VBG cord-344988-09vpehvf 135 15 the the DT cord-344988-09vpehvf 135 16 use use NN cord-344988-09vpehvf 135 17 of of IN cord-344988-09vpehvf 135 18 zinc zinc NN cord-344988-09vpehvf 135 19 for for IN cord-344988-09vpehvf 135 20 the the DT cord-344988-09vpehvf 135 21 prevention prevention NN cord-344988-09vpehvf 135 22 or or CC cord-344988-09vpehvf 135 23 treatment treatment NN cord-344988-09vpehvf 135 24 of of IN cord-344988-09vpehvf 135 25 diarrhea diarrhea NN cord-344988-09vpehvf 135 26 in in IN cord-344988-09vpehvf 135 27 children child NNS cord-344988-09vpehvf 135 28 in in IN cord-344988-09vpehvf 135 29 developing develop VBG cord-344988-09vpehvf 135 30 countries country NNS cord-344988-09vpehvf 135 31 [ [ -LRB- cord-344988-09vpehvf 135 32 14 14 CD cord-344988-09vpehvf 135 33 , , , cord-344988-09vpehvf 135 34 15 15 CD cord-344988-09vpehvf 135 35 ] ] -RRB- cord-344988-09vpehvf 135 36 . . . cord-344988-09vpehvf 136 1 The the DT cord-344988-09vpehvf 136 2 combined combined JJ cord-344988-09vpehvf 136 3 results result NNS cord-344988-09vpehvf 136 4 of of IN cord-344988-09vpehvf 136 5 seven seven CD cord-344988-09vpehvf 136 6 trials trial NNS cord-344988-09vpehvf 136 7 of of IN cord-344988-09vpehvf 136 8 continuous continuous JJ cord-344988-09vpehvf 136 9 zinc zinc NN cord-344988-09vpehvf 136 10 supplementation supplementation NN cord-344988-09vpehvf 136 11 confirmed confirm VBD cord-344988-09vpehvf 136 12 that that IN cord-344988-09vpehvf 136 13 zinc zinc NN cord-344988-09vpehvf 136 14 significantly significantly RB cord-344988-09vpehvf 136 15 reduces reduce VBZ cord-344988-09vpehvf 136 16 the the DT cord-344988-09vpehvf 136 17 incidence incidence NN cord-344988-09vpehvf 136 18 and and CC cord-344988-09vpehvf 136 19 prevalence prevalence NN cord-344988-09vpehvf 136 20 of of IN cord-344988-09vpehvf 136 21 diarrhea diarrhea NN cord-344988-09vpehvf 136 22 [ [ -LRB- cord-344988-09vpehvf 136 23 14 14 CD cord-344988-09vpehvf 136 24 ] ] -RRB- cord-344988-09vpehvf 136 25 . . . cord-344988-09vpehvf 137 1 When when WRB cord-344988-09vpehvf 137 2 zinc zinc NN cord-344988-09vpehvf 137 3 was be VBD cord-344988-09vpehvf 137 4 used use VBN cord-344988-09vpehvf 137 5 for for IN cord-344988-09vpehvf 137 6 the the DT cord-344988-09vpehvf 137 7 treatment treatment NN cord-344988-09vpehvf 137 8 of of IN cord-344988-09vpehvf 137 9 acute acute JJ cord-344988-09vpehvf 137 10 and and CC cord-344988-09vpehvf 137 11 persistent persistent JJ cord-344988-09vpehvf 137 12 diarrhea diarrhea NN cord-344988-09vpehvf 137 13 , , , cord-344988-09vpehvf 137 14 the the DT cord-344988-09vpehvf 137 15 probability probability NN cord-344988-09vpehvf 137 16 of of IN cord-344988-09vpehvf 137 17 continuation continuation NN cord-344988-09vpehvf 137 18 was be VBD cord-344988-09vpehvf 137 19 reduced reduce VBN cord-344988-09vpehvf 137 20 and and CC cord-344988-09vpehvf 137 21 the the DT cord-344988-09vpehvf 137 22 rate rate NN cord-344988-09vpehvf 137 23 of of IN cord-344988-09vpehvf 137 24 treatment treatment NN cord-344988-09vpehvf 137 25 failure failure NN cord-344988-09vpehvf 137 26 or or CC cord-344988-09vpehvf 137 27 death death NN cord-344988-09vpehvf 137 28 was be VBD cord-344988-09vpehvf 137 29 diminished diminish VBN cord-344988-09vpehvf 137 30 by by IN cord-344988-09vpehvf 137 31 42 42 CD cord-344988-09vpehvf 137 32 % % NN cord-344988-09vpehvf 137 33 . . . cord-344988-09vpehvf 138 1 These these DT cord-344988-09vpehvf 138 2 results result NNS cord-344988-09vpehvf 138 3 caused cause VBD cord-344988-09vpehvf 138 4 the the DT cord-344988-09vpehvf 138 5 authors author NNS cord-344988-09vpehvf 138 6 to to TO cord-344988-09vpehvf 138 7 conclude conclude VB cord-344988-09vpehvf 138 8 a a DT cord-344988-09vpehvf 138 9 substantial substantial JJ cord-344988-09vpehvf 138 10 benefit benefit NN cord-344988-09vpehvf 138 11 of of IN cord-344988-09vpehvf 138 12 zinc zinc NN cord-344988-09vpehvf 138 13 supplementation supplementation NN cord-344988-09vpehvf 138 14 for for IN cord-344988-09vpehvf 138 15 the the DT cord-344988-09vpehvf 138 16 treatment treatment NN cord-344988-09vpehvf 138 17 of of IN cord-344988-09vpehvf 138 18 both both CC cord-344988-09vpehvf 138 19 acute acute JJ cord-344988-09vpehvf 138 20 and and CC cord-344988-09vpehvf 138 21 persistent persistent JJ cord-344988-09vpehvf 138 22 diarrhea diarrhea NN cord-344988-09vpehvf 138 23 in in IN cord-344988-09vpehvf 138 24 children child NNS cord-344988-09vpehvf 138 25 [ [ -LRB- cord-344988-09vpehvf 138 26 15 15 CD cord-344988-09vpehvf 138 27 ] ] -RRB- cord-344988-09vpehvf 138 28 . . . cord-344988-09vpehvf 139 1 However however RB cord-344988-09vpehvf 139 2 , , , cord-344988-09vpehvf 139 3 a a DT cord-344988-09vpehvf 139 4 recent recent JJ cord-344988-09vpehvf 139 5 report report NN cord-344988-09vpehvf 139 6 points point VBZ cord-344988-09vpehvf 139 7 out out RP cord-344988-09vpehvf 139 8 that that IN cord-344988-09vpehvf 139 9 this this DT cord-344988-09vpehvf 139 10 may may MD cord-344988-09vpehvf 139 11 not not RB cord-344988-09vpehvf 139 12 be be VB cord-344988-09vpehvf 139 13 the the DT cord-344988-09vpehvf 139 14 case case NN cord-344988-09vpehvf 139 15 for for IN cord-344988-09vpehvf 139 16 infants infant NNS cord-344988-09vpehvf 139 17 younger young JJR cord-344988-09vpehvf 139 18 than than IN cord-344988-09vpehvf 139 19 six six CD cord-344988-09vpehvf 139 20 months month NNS cord-344988-09vpehvf 139 21 of of IN cord-344988-09vpehvf 139 22 age age NN cord-344988-09vpehvf 139 23 [ [ -LRB- cord-344988-09vpehvf 139 24 166 166 CD cord-344988-09vpehvf 139 25 ] ] -RRB- cord-344988-09vpehvf 139 26 . . . cord-344988-09vpehvf 140 1 Diarrhea diarrhea NN cord-344988-09vpehvf 140 2 leads lead VBZ cord-344988-09vpehvf 140 3 to to IN cord-344988-09vpehvf 140 4 increased increase VBN cord-344988-09vpehvf 140 5 intestinal intestinal JJ cord-344988-09vpehvf 140 6 loss loss NN cord-344988-09vpehvf 140 7 and and CC cord-344988-09vpehvf 140 8 malnutrition malnutrition NN cord-344988-09vpehvf 140 9 with with IN cord-344988-09vpehvf 140 10 micronutrients micronutrient NNS cord-344988-09vpehvf 140 11 , , , cord-344988-09vpehvf 140 12 including include VBG cord-344988-09vpehvf 140 13 zinc zinc NN cord-344988-09vpehvf 140 14 . . . cord-344988-09vpehvf 141 1 This this DT cord-344988-09vpehvf 141 2 loss loss NN cord-344988-09vpehvf 141 3 can can MD cord-344988-09vpehvf 141 4 be be VB cord-344988-09vpehvf 141 5 corrected correct VBN cord-344988-09vpehvf 141 6 by by IN cord-344988-09vpehvf 141 7 oral oral JJ cord-344988-09vpehvf 141 8 zinc zinc NN cord-344988-09vpehvf 141 9 supplementation supplementation NN cord-344988-09vpehvf 141 10 , , , cord-344988-09vpehvf 141 11 which which WDT cord-344988-09vpehvf 141 12 may may MD cord-344988-09vpehvf 141 13 improve improve VB cord-344988-09vpehvf 141 14 the the DT cord-344988-09vpehvf 141 15 absorption absorption NN cord-344988-09vpehvf 141 16 of of IN cord-344988-09vpehvf 141 17 water water NN cord-344988-09vpehvf 141 18 and and CC cord-344988-09vpehvf 141 19 electrolytes electrolyte NNS cord-344988-09vpehvf 141 20 by by IN cord-344988-09vpehvf 141 21 the the DT cord-344988-09vpehvf 141 22 intestine intestine NN cord-344988-09vpehvf 141 23 [ [ -LRB- cord-344988-09vpehvf 141 24 52 52 CD cord-344988-09vpehvf 141 25 , , , cord-344988-09vpehvf 141 26 63 63 CD cord-344988-09vpehvf 141 27 , , , cord-344988-09vpehvf 141 28 108 108 CD cord-344988-09vpehvf 141 29 ] ] -RRB- cord-344988-09vpehvf 141 30 , , , cord-344988-09vpehvf 141 31 lead lead VBP cord-344988-09vpehvf 141 32 to to IN cord-344988-09vpehvf 141 33 a a DT cord-344988-09vpehvf 141 34 faster fast JJR cord-344988-09vpehvf 141 35 regeneration regeneration NN cord-344988-09vpehvf 141 36 of of IN cord-344988-09vpehvf 141 37 the the DT cord-344988-09vpehvf 141 38 gut gut NN cord-344988-09vpehvf 141 39 epithelium epithelium NN cord-344988-09vpehvf 141 40 [ [ -LRB- cord-344988-09vpehvf 141 41 12 12 CD cord-344988-09vpehvf 141 42 ] ] -RRB- cord-344988-09vpehvf 141 43 , , , cord-344988-09vpehvf 141 44 and and CC cord-344988-09vpehvf 141 45 increase increase VB cord-344988-09vpehvf 141 46 the the DT cord-344988-09vpehvf 141 47 levels level NNS cord-344988-09vpehvf 141 48 of of IN cord-344988-09vpehvf 141 49 enterocyte enterocyte NNP cord-344988-09vpehvf 141 50 brush brush NN cord-344988-09vpehvf 141 51 - - HYPH cord-344988-09vpehvf 141 52 border border NN cord-344988-09vpehvf 141 53 enzymes enzyme NNS cord-344988-09vpehvf 141 54 [ [ -LRB- cord-344988-09vpehvf 141 55 49 49 CD cord-344988-09vpehvf 141 56 , , , cord-344988-09vpehvf 141 57 106 106 CD cord-344988-09vpehvf 141 58 ] ] -RRB- cord-344988-09vpehvf 141 59 . . . cord-344988-09vpehvf 142 1 Finally finally RB cord-344988-09vpehvf 142 2 , , , cord-344988-09vpehvf 142 3 the the DT cord-344988-09vpehvf 142 4 loss loss NN cord-344988-09vpehvf 142 5 of of IN cord-344988-09vpehvf 142 6 zinc zinc NN cord-344988-09vpehvf 142 7 may may MD cord-344988-09vpehvf 142 8 negatively negatively RB cord-344988-09vpehvf 142 9 affect affect VB cord-344988-09vpehvf 142 10 immune immune JJ cord-344988-09vpehvf 142 11 function function NN cord-344988-09vpehvf 142 12 , , , cord-344988-09vpehvf 142 13 which which WDT cord-344988-09vpehvf 142 14 can can MD cord-344988-09vpehvf 142 15 be be VB cord-344988-09vpehvf 142 16 antagonized antagonize VBN cord-344988-09vpehvf 142 17 by by IN cord-344988-09vpehvf 142 18 zinc zinc NN cord-344988-09vpehvf 142 19 supplementation supplementation NN cord-344988-09vpehvf 142 20 to to TO cord-344988-09vpehvf 142 21 improve improve VB cord-344988-09vpehvf 142 22 the the DT cord-344988-09vpehvf 142 23 clearance clearance NN cord-344988-09vpehvf 142 24 of of IN cord-344988-09vpehvf 142 25 bacterial bacterial JJ cord-344988-09vpehvf 142 26 pathogens pathogen NNS cord-344988-09vpehvf 142 27 from from IN cord-344988-09vpehvf 142 28 the the DT cord-344988-09vpehvf 142 29 intestine intestine NN cord-344988-09vpehvf 142 30 [ [ -LRB- cord-344988-09vpehvf 142 31 146 146 CD cord-344988-09vpehvf 142 32 ] ] -RRB- cord-344988-09vpehvf 142 33 . . . cord-344988-09vpehvf 143 1 When when WRB cord-344988-09vpehvf 143 2 zinc zinc NN cord-344988-09vpehvf 143 3 supplementation supplementation NN cord-344988-09vpehvf 143 4 was be VBD cord-344988-09vpehvf 143 5 examined examine VBN cord-344988-09vpehvf 143 6 in in IN cord-344988-09vpehvf 143 7 patients patient NNS cord-344988-09vpehvf 143 8 with with IN cord-344988-09vpehvf 143 9 shigellosis shigellosis NN cord-344988-09vpehvf 143 10 , , , cord-344988-09vpehvf 143 11 which which WDT cord-344988-09vpehvf 143 12 is be VBZ cord-344988-09vpehvf 143 13 induced induce VBN cord-344988-09vpehvf 143 14 by by IN cord-344988-09vpehvf 143 15 different different JJ cord-344988-09vpehvf 143 16 species specie NNS cord-344988-09vpehvf 143 17 of of IN cord-344988-09vpehvf 143 18 Shigella Shigella NNP cord-344988-09vpehvf 143 19 , , , cord-344988-09vpehvf 143 20 several several JJ cord-344988-09vpehvf 143 21 studies study NNS cord-344988-09vpehvf 143 22 report report VBP cord-344988-09vpehvf 143 23 improvements improvement NNS cord-344988-09vpehvf 143 24 . . . cord-344988-09vpehvf 144 1 These these DT cord-344988-09vpehvf 144 2 include include VBP cord-344988-09vpehvf 144 3 increased increase VBN cord-344988-09vpehvf 144 4 intestinal intestinal JJ cord-344988-09vpehvf 144 5 mucosal mucosal JJ cord-344988-09vpehvf 144 6 permeability permeability NN cord-344988-09vpehvf 144 7 , , , cord-344988-09vpehvf 144 8 alkaline alkaline JJ cord-344988-09vpehvf 144 9 phosphatase phosphatase NN cord-344988-09vpehvf 144 10 activity activity NN cord-344988-09vpehvf 144 11 and and CC cord-344988-09vpehvf 144 12 better well JJR cord-344988-09vpehvf 144 13 nitrogen nitrogen NN cord-344988-09vpehvf 144 14 absorption absorption NN cord-344988-09vpehvf 144 15 [ [ -LRB- cord-344988-09vpehvf 144 16 3 3 CD cord-344988-09vpehvf 144 17 ] ] -RRB- cord-344988-09vpehvf 144 18 , , , cord-344988-09vpehvf 144 19 but but CC cord-344988-09vpehvf 144 20 also also RB cord-344988-09vpehvf 144 21 augmented augment VBN cord-344988-09vpehvf 144 22 lymphocyte lymphocyte NN cord-344988-09vpehvf 144 23 proliferation proliferation NN cord-344988-09vpehvf 144 24 in in IN cord-344988-09vpehvf 144 25 response response NN cord-344988-09vpehvf 144 26 to to IN cord-344988-09vpehvf 144 27 phytohemagglutinin phytohemagglutinin NN cord-344988-09vpehvf 144 28 and and CC cord-344988-09vpehvf 144 29 increased increase VBN cord-344988-09vpehvf 144 30 antigen antigen NN cord-344988-09vpehvf 144 31 - - HYPH cord-344988-09vpehvf 144 32 specific specific JJ cord-344988-09vpehvf 144 33 IgG igg NN cord-344988-09vpehvf 144 34 titers titer NNS cord-344988-09vpehvf 144 35 [ [ -LRB- cord-344988-09vpehvf 144 36 125 125 CD cord-344988-09vpehvf 144 37 ] ] -RRB- cord-344988-09vpehvf 144 38 . . . cord-344988-09vpehvf 145 1 In in IN cord-344988-09vpehvf 145 2 addition addition NN cord-344988-09vpehvf 145 3 , , , cord-344988-09vpehvf 145 4 augmented augment VBN cord-344988-09vpehvf 145 5 serum serum NN cord-344988-09vpehvf 145 6 antibody antibody NN cord-344988-09vpehvf 145 7 titers titer NNS cord-344988-09vpehvf 145 8 together together RB cord-344988-09vpehvf 145 9 with with IN cord-344988-09vpehvf 145 10 an an DT cord-344988-09vpehvf 145 11 increase increase NN cord-344988-09vpehvf 145 12 in in IN cord-344988-09vpehvf 145 13 CD20 cd20 NN cord-344988-09vpehvf 145 14 + + CC cord-344988-09vpehvf 145 15 cells cell NNS cord-344988-09vpehvf 145 16 ( ( -LRB- cord-344988-09vpehvf 145 17 B b NN cord-344988-09vpehvf 145 18 cells cell NNS cord-344988-09vpehvf 145 19 ) ) -RRB- cord-344988-09vpehvf 146 1 and and CC cord-344988-09vpehvf 146 2 CD20 CD20 NNP cord-344988-09vpehvf 146 3 + + CC cord-344988-09vpehvf 146 4 /CD38 /CD38 NNP cord-344988-09vpehvf 146 5 + + CC cord-344988-09vpehvf 146 6 cells cell NNS cord-344988-09vpehvf 146 7 ( ( -LRB- cord-344988-09vpehvf 146 8 plasma plasma NN cord-344988-09vpehvf 146 9 cells cell NNS cord-344988-09vpehvf 146 10 ) ) -RRB- cord-344988-09vpehvf 146 11 were be VBD cord-344988-09vpehvf 146 12 observed observe VBN cord-344988-09vpehvf 146 13 [ [ -LRB- cord-344988-09vpehvf 146 14 124 124 CD cord-344988-09vpehvf 146 15 ] ] -RRB- cord-344988-09vpehvf 146 16 . . . cord-344988-09vpehvf 147 1 All all PDT cord-344988-09vpehvf 147 2 these these DT cord-344988-09vpehvf 147 3 effects effect NNS cord-344988-09vpehvf 147 4 indicate indicate VBP cord-344988-09vpehvf 147 5 that that IN cord-344988-09vpehvf 147 6 the the DT cord-344988-09vpehvf 147 7 effect effect NN cord-344988-09vpehvf 147 8 of of IN cord-344988-09vpehvf 147 9 zinc zinc NN cord-344988-09vpehvf 147 10 is be VBZ cord-344988-09vpehvf 147 11 likely likely RB cord-344988-09vpehvf 147 12 mediated mediate VBN cord-344988-09vpehvf 147 13 by by IN cord-344988-09vpehvf 147 14 a a DT cord-344988-09vpehvf 147 15 modulation modulation NN cord-344988-09vpehvf 147 16 of of IN cord-344988-09vpehvf 147 17 immune immune JJ cord-344988-09vpehvf 147 18 function function NN cord-344988-09vpehvf 147 19 . . . cord-344988-09vpehvf 148 1 Leprosy leprosy NN cord-344988-09vpehvf 148 2 is be VBZ cord-344988-09vpehvf 148 3 induced induce VBN cord-344988-09vpehvf 148 4 by by IN cord-344988-09vpehvf 148 5 infection infection NN cord-344988-09vpehvf 148 6 with with IN cord-344988-09vpehvf 148 7 the the DT cord-344988-09vpehvf 148 8 pathogen pathogen NN cord-344988-09vpehvf 148 9 Mycobacterium Mycobacterium NNP cord-344988-09vpehvf 148 10 leprae leprae NNP cord-344988-09vpehvf 148 11 . . . cord-344988-09vpehvf 149 1 Leprosy leprosy NN cord-344988-09vpehvf 149 2 patients patient NNS cord-344988-09vpehvf 149 3 with with IN cord-344988-09vpehvf 149 4 borderline borderline JJ cord-344988-09vpehvf 149 5 tuberculoid tuberculoid NNP cord-344988-09vpehvf 149 6 leprosy leprosy NN cord-344988-09vpehvf 149 7 , , , cord-344988-09vpehvf 149 8 borderline borderline JJ cord-344988-09vpehvf 149 9 lepromatous lepromatous JJ cord-344988-09vpehvf 149 10 leprosy leprosy NN cord-344988-09vpehvf 149 11 , , , cord-344988-09vpehvf 149 12 and and CC cord-344988-09vpehvf 149 13 lepromatous lepromatous JJ cord-344988-09vpehvf 149 14 leprosy leprosy NN cord-344988-09vpehvf 149 15 have have VBP cord-344988-09vpehvf 149 16 reduced reduce VBN cord-344988-09vpehvf 149 17 serum serum NN cord-344988-09vpehvf 149 18 zinc zinc NN cord-344988-09vpehvf 149 19 levels level NNS cord-344988-09vpehvf 149 20 [ [ -LRB- cord-344988-09vpehvf 149 21 51 51 CD cord-344988-09vpehvf 149 22 ] ] -RRB- cord-344988-09vpehvf 149 23 . . . cord-344988-09vpehvf 150 1 Hence hence RB cord-344988-09vpehvf 150 2 , , , cord-344988-09vpehvf 150 3 several several JJ cord-344988-09vpehvf 150 4 zinc zinc NN cord-344988-09vpehvf 150 5 supplementation supplementation NN cord-344988-09vpehvf 150 6 studies study NNS cord-344988-09vpehvf 150 7 have have VBP cord-344988-09vpehvf 150 8 been be VBN cord-344988-09vpehvf 150 9 conducted conduct VBN cord-344988-09vpehvf 150 10 . . . cord-344988-09vpehvf 151 1 All all DT cord-344988-09vpehvf 151 2 of of IN cord-344988-09vpehvf 151 3 them -PRON- PRP cord-344988-09vpehvf 151 4 reported report VBD cord-344988-09vpehvf 151 5 different different JJ cord-344988-09vpehvf 151 6 , , , cord-344988-09vpehvf 151 7 but but CC cord-344988-09vpehvf 151 8 beneficial beneficial JJ cord-344988-09vpehvf 151 9 , , , cord-344988-09vpehvf 151 10 effects effect NNS cord-344988-09vpehvf 151 11 . . . cord-344988-09vpehvf 152 1 One one CD cord-344988-09vpehvf 152 2 study study NN cord-344988-09vpehvf 152 3 found find VBD cord-344988-09vpehvf 152 4 a a DT cord-344988-09vpehvf 152 5 reduction reduction NN cord-344988-09vpehvf 152 6 in in IN cord-344988-09vpehvf 152 7 the the DT cord-344988-09vpehvf 152 8 required required JJ cord-344988-09vpehvf 152 9 dose dose NN cord-344988-09vpehvf 152 10 of of IN cord-344988-09vpehvf 152 11 clofazimine clofazimine NNP cord-344988-09vpehvf 152 12 , , , cord-344988-09vpehvf 152 13 a a DT cord-344988-09vpehvf 152 14 withdrawal withdrawal NN cord-344988-09vpehvf 152 15 of of IN cord-344988-09vpehvf 152 16 primarily primarily RB cord-344988-09vpehvf 152 17 essential essential JJ cord-344988-09vpehvf 152 18 steroids steroid NNS cord-344988-09vpehvf 152 19 , , , cord-344988-09vpehvf 152 20 and and CC cord-344988-09vpehvf 152 21 an an DT cord-344988-09vpehvf 152 22 improved improved JJ cord-344988-09vpehvf 152 23 toleration toleration NN cord-344988-09vpehvf 152 24 of of IN cord-344988-09vpehvf 152 25 dapsone dapsone NN cord-344988-09vpehvf 152 26 after after IN cord-344988-09vpehvf 152 27 zinc zinc NN cord-344988-09vpehvf 152 28 treatment treatment NN cord-344988-09vpehvf 152 29 . . . cord-344988-09vpehvf 153 1 Furthermore furthermore RB cord-344988-09vpehvf 153 2 , , , cord-344988-09vpehvf 153 3 they -PRON- PRP cord-344988-09vpehvf 153 4 observed observe VBD cord-344988-09vpehvf 153 5 a a DT cord-344988-09vpehvf 153 6 reduced reduce VBN cord-344988-09vpehvf 153 7 incidence incidence NN cord-344988-09vpehvf 153 8 and and CC cord-344988-09vpehvf 153 9 severity severity NN cord-344988-09vpehvf 153 10 of of IN cord-344988-09vpehvf 153 11 erythema erythema NNP cord-344988-09vpehvf 153 12 nodosum nodosum NNP cord-344988-09vpehvf 153 13 leprosum leprosum NNP cord-344988-09vpehvf 153 14 , , , cord-344988-09vpehvf 153 15 a a DT cord-344988-09vpehvf 153 16 gradual gradual JJ cord-344988-09vpehvf 153 17 decrease decrease NN cord-344988-09vpehvf 153 18 in in IN cord-344988-09vpehvf 153 19 the the DT cord-344988-09vpehvf 153 20 size size NN cord-344988-09vpehvf 153 21 of of IN cord-344988-09vpehvf 153 22 granuloma granuloma NN cord-344988-09vpehvf 153 23 , , , cord-344988-09vpehvf 153 24 and and CC cord-344988-09vpehvf 153 25 a a DT cord-344988-09vpehvf 153 26 gradual gradual JJ cord-344988-09vpehvf 153 27 increase increase NN cord-344988-09vpehvf 153 28 in in IN cord-344988-09vpehvf 153 29 the the DT cord-344988-09vpehvf 153 30 number number NN cord-344988-09vpehvf 153 31 of of IN cord-344988-09vpehvf 153 32 lymphocytes lymphocyte NNS cord-344988-09vpehvf 153 33 [ [ -LRB- cord-344988-09vpehvf 153 34 89 89 CD cord-344988-09vpehvf 153 35 ] ] -RRB- cord-344988-09vpehvf 153 36 . . . cord-344988-09vpehvf 154 1 Another another DT cord-344988-09vpehvf 154 2 study study NN cord-344988-09vpehvf 154 3 reported report VBD cord-344988-09vpehvf 154 4 a a DT cord-344988-09vpehvf 154 5 decreased decrease VBN cord-344988-09vpehvf 154 6 incidence incidence NN cord-344988-09vpehvf 154 7 of of IN cord-344988-09vpehvf 154 8 erythema erythema NN cord-344988-09vpehvf 154 9 , , , cord-344988-09vpehvf 154 10 edema edema NN cord-344988-09vpehvf 154 11 , , , cord-344988-09vpehvf 154 12 and and CC cord-344988-09vpehvf 154 13 infiltration infiltration NN cord-344988-09vpehvf 154 14 as as RB cord-344988-09vpehvf 154 15 well well RB cord-344988-09vpehvf 154 16 as as IN cord-344988-09vpehvf 154 17 a a DT cord-344988-09vpehvf 154 18 reduced reduce VBN cord-344988-09vpehvf 154 19 bacterial bacterial JJ cord-344988-09vpehvf 154 20 index index NN cord-344988-09vpehvf 154 21 of of IN cord-344988-09vpehvf 154 22 granuloma granuloma NN cord-344988-09vpehvf 154 23 . . . cord-344988-09vpehvf 155 1 In in IN cord-344988-09vpehvf 155 2 addition addition NN cord-344988-09vpehvf 155 3 , , , cord-344988-09vpehvf 155 4 there there EX cord-344988-09vpehvf 155 5 was be VBD cord-344988-09vpehvf 155 6 a a DT cord-344988-09vpehvf 155 7 regrowth regrowth NN cord-344988-09vpehvf 155 8 of of IN cord-344988-09vpehvf 155 9 eyebrows eyebrow NNS cord-344988-09vpehvf 155 10 and and CC cord-344988-09vpehvf 155 11 an an DT cord-344988-09vpehvf 155 12 increase increase NN cord-344988-09vpehvf 155 13 in in IN cord-344988-09vpehvf 155 14 neovascularization neovascularization NN cord-344988-09vpehvf 155 15 and and CC cord-344988-09vpehvf 155 16 endothelial endothelial JJ cord-344988-09vpehvf 155 17 cell cell NN cord-344988-09vpehvf 155 18 proliferation proliferation NN cord-344988-09vpehvf 155 19 [ [ -LRB- cord-344988-09vpehvf 155 20 90 90 CD cord-344988-09vpehvf 155 21 ] ] -RRB- cord-344988-09vpehvf 155 22 . . . cord-344988-09vpehvf 156 1 Those those DT cord-344988-09vpehvf 156 2 beneficial beneficial JJ cord-344988-09vpehvf 156 3 effects effect NNS cord-344988-09vpehvf 156 4 of of IN cord-344988-09vpehvf 156 5 zinc zinc NN cord-344988-09vpehvf 156 6 treatment treatment NN cord-344988-09vpehvf 156 7 were be VBD cord-344988-09vpehvf 156 8 confirmed confirm VBN cord-344988-09vpehvf 156 9 by by IN cord-344988-09vpehvf 156 10 two two CD cord-344988-09vpehvf 156 11 other other JJ cord-344988-09vpehvf 156 12 studies study NNS cord-344988-09vpehvf 156 13 [ [ -LRB- cord-344988-09vpehvf 156 14 36 36 CD cord-344988-09vpehvf 156 15 , , , cord-344988-09vpehvf 156 16 84 84 CD cord-344988-09vpehvf 156 17 ] ] -RRB- cord-344988-09vpehvf 156 18 , , , cord-344988-09vpehvf 156 19 which which WDT cord-344988-09vpehvf 156 20 detected detect VBD cord-344988-09vpehvf 156 21 decreased decrease VBD cord-344988-09vpehvf 156 22 size size NN cord-344988-09vpehvf 156 23 of of IN cord-344988-09vpehvf 156 24 skin skin NN cord-344988-09vpehvf 156 25 nodules nodule NNS cord-344988-09vpehvf 156 26 , , , cord-344988-09vpehvf 156 27 improved improve VBD cord-344988-09vpehvf 156 28 delayed delayed JJ cord-344988-09vpehvf 156 29 hypersensitivity hypersensitivity NN cord-344988-09vpehvf 156 30 reactions reaction NNS cord-344988-09vpehvf 156 31 , , , cord-344988-09vpehvf 156 32 a a DT cord-344988-09vpehvf 156 33 disappearance disappearance NN cord-344988-09vpehvf 156 34 of of IN cord-344988-09vpehvf 156 35 erythema erythema NN cord-344988-09vpehvf 156 36 and and CC cord-344988-09vpehvf 156 37 a a DT cord-344988-09vpehvf 156 38 regrowth regrowth NN cord-344988-09vpehvf 156 39 of of IN cord-344988-09vpehvf 156 40 eyebrows eyebrow NNS cord-344988-09vpehvf 156 41 [ [ -LRB- cord-344988-09vpehvf 156 42 36 36 CD cord-344988-09vpehvf 156 43 ] ] -RRB- cord-344988-09vpehvf 156 44 as as RB cord-344988-09vpehvf 156 45 well well RB cord-344988-09vpehvf 156 46 as as IN cord-344988-09vpehvf 156 47 improvements improvement NNS cord-344988-09vpehvf 156 48 regarding regard VBG cord-344988-09vpehvf 156 49 frequency frequency NN cord-344988-09vpehvf 156 50 , , , cord-344988-09vpehvf 156 51 duration duration NN cord-344988-09vpehvf 156 52 , , , cord-344988-09vpehvf 156 53 and and CC cord-344988-09vpehvf 156 54 severity severity NN cord-344988-09vpehvf 156 55 of of IN cord-344988-09vpehvf 156 56 erythema erythema NNP cord-344988-09vpehvf 156 57 nodosum nodosum NNP cord-344988-09vpehvf 156 58 leprosum leprosum NNP cord-344988-09vpehvf 156 59 reactions reaction NNS cord-344988-09vpehvf 156 60 , , , cord-344988-09vpehvf 156 61 and and CC cord-344988-09vpehvf 156 62 a a DT cord-344988-09vpehvf 156 63 reduction reduction NN cord-344988-09vpehvf 156 64 in in IN cord-344988-09vpehvf 156 65 steroid steroid NN cord-344988-09vpehvf 156 66 requirements requirement NNS cord-344988-09vpehvf 156 67 [ [ -LRB- cord-344988-09vpehvf 156 68 84 84 CD cord-344988-09vpehvf 156 69 ] ] -RRB- cord-344988-09vpehvf 156 70 . . . cord-344988-09vpehvf 157 1 Another another DT cord-344988-09vpehvf 157 2 form form NN cord-344988-09vpehvf 157 3 of of IN cord-344988-09vpehvf 157 4 mycobacterial mycobacterial JJ cord-344988-09vpehvf 157 5 infection infection NN cord-344988-09vpehvf 157 6 is be VBZ cord-344988-09vpehvf 157 7 tuberculosis tuberculosis NN cord-344988-09vpehvf 157 8 , , , cord-344988-09vpehvf 157 9 which which WDT cord-344988-09vpehvf 157 10 is be VBZ cord-344988-09vpehvf 157 11 caused cause VBN cord-344988-09vpehvf 157 12 by by IN cord-344988-09vpehvf 157 13 the the DT cord-344988-09vpehvf 157 14 pathogen pathogen NN cord-344988-09vpehvf 157 15 Mycobacterium Mycobacterium NNP cord-344988-09vpehvf 157 16 tuberculosis tuberculosis NN cord-344988-09vpehvf 157 17 and and CC cord-344988-09vpehvf 157 18 associated associate VBN cord-344988-09vpehvf 157 19 with with IN cord-344988-09vpehvf 157 20 lower low JJR cord-344988-09vpehvf 157 21 serum serum NN cord-344988-09vpehvf 157 22 zinc zinc NN cord-344988-09vpehvf 157 23 levels level NNS cord-344988-09vpehvf 157 24 [ [ -LRB- cord-344988-09vpehvf 157 25 22 22 CD cord-344988-09vpehvf 157 26 ] ] -RRB- cord-344988-09vpehvf 157 27 . . . cord-344988-09vpehvf 158 1 Here here RB cord-344988-09vpehvf 158 2 , , , cord-344988-09vpehvf 158 3 one one CD cord-344988-09vpehvf 158 4 study study NN cord-344988-09vpehvf 158 5 reported report VBD cord-344988-09vpehvf 158 6 an an DT cord-344988-09vpehvf 158 7 increase increase NN cord-344988-09vpehvf 158 8 in in IN cord-344988-09vpehvf 158 9 plasma plasma NN cord-344988-09vpehvf 158 10 retinol retinol NN cord-344988-09vpehvf 158 11 concentration concentration NN cord-344988-09vpehvf 158 12 , , , cord-344988-09vpehvf 158 13 earlier early JJR cord-344988-09vpehvf 158 14 sputum sputum NN cord-344988-09vpehvf 158 15 conversion conversion NN cord-344988-09vpehvf 158 16 , , , cord-344988-09vpehvf 158 17 and and CC cord-344988-09vpehvf 158 18 resolution resolution NN cord-344988-09vpehvf 158 19 of of IN cord-344988-09vpehvf 158 20 X x NN cord-344988-09vpehvf 158 21 - - NN cord-344988-09vpehvf 158 22 ray ray JJ cord-344988-09vpehvf 158 23 lesion lesion NN cord-344988-09vpehvf 158 24 areas area NNS cord-344988-09vpehvf 158 25 in in IN cord-344988-09vpehvf 158 26 response response NN cord-344988-09vpehvf 158 27 to to IN cord-344988-09vpehvf 158 28 zinc zinc NN cord-344988-09vpehvf 158 29 supplementation supplementation NN cord-344988-09vpehvf 158 30 [ [ -LRB- cord-344988-09vpehvf 158 31 69 69 CD cord-344988-09vpehvf 158 32 ] ] -RRB- cord-344988-09vpehvf 158 33 . . . cord-344988-09vpehvf 159 1 Effective effective JJ cord-344988-09vpehvf 159 2 clearance clearance NN cord-344988-09vpehvf 159 3 of of IN cord-344988-09vpehvf 159 4 mycobacterial mycobacterial JJ cord-344988-09vpehvf 159 5 infections infection NNS cord-344988-09vpehvf 159 6 requires require VBZ cord-344988-09vpehvf 159 7 a a DT cord-344988-09vpehvf 159 8 TH1-mediated th1-mediate VBN cord-344988-09vpehvf 159 9 activation activation NN cord-344988-09vpehvf 159 10 of of IN cord-344988-09vpehvf 159 11 infected infected JJ cord-344988-09vpehvf 159 12 macrophages macrophage NNS cord-344988-09vpehvf 159 13 by by IN cord-344988-09vpehvf 159 14 IFN IFN NNP cord-344988-09vpehvf 159 15 - - HYPH cord-344988-09vpehvf 159 16 γ γ NNP cord-344988-09vpehvf 159 17 [ [ -LRB- cord-344988-09vpehvf 159 18 42 42 CD cord-344988-09vpehvf 159 19 ] ] -RRB- cord-344988-09vpehvf 159 20 . . . cord-344988-09vpehvf 160 1 Studies study NNS cord-344988-09vpehvf 160 2 in in IN cord-344988-09vpehvf 160 3 mice mouse NNS cord-344988-09vpehvf 160 4 showed show VBD cord-344988-09vpehvf 160 5 that that IN cord-344988-09vpehvf 160 6 zinc zinc NN cord-344988-09vpehvf 160 7 may may MD cord-344988-09vpehvf 160 8 improve improve VB cord-344988-09vpehvf 160 9 an an DT cord-344988-09vpehvf 160 10 imbalance imbalance NN cord-344988-09vpehvf 160 11 in in IN cord-344988-09vpehvf 160 12 T t NN cord-344988-09vpehvf 160 13 cell cell NN cord-344988-09vpehvf 160 14 subpopulations subpopulation NNS cord-344988-09vpehvf 160 15 , , , cord-344988-09vpehvf 160 16 which which WDT cord-344988-09vpehvf 160 17 reflects reflect VBZ cord-344988-09vpehvf 160 18 a a DT cord-344988-09vpehvf 160 19 disturbed disturbed JJ cord-344988-09vpehvf 160 20 helper helper NN cord-344988-09vpehvf 160 21 / / SYM cord-344988-09vpehvf 160 22 suppressor suppressor NN cord-344988-09vpehvf 160 23 cell cell NN cord-344988-09vpehvf 160 24 ratio ratio NN cord-344988-09vpehvf 160 25 . . . cord-344988-09vpehvf 161 1 Here here RB cord-344988-09vpehvf 161 2 , , , cord-344988-09vpehvf 161 3 zinc zinc NN cord-344988-09vpehvf 161 4 acts act NNS cord-344988-09vpehvf 161 5 by by IN cord-344988-09vpehvf 161 6 inducing induce VBG cord-344988-09vpehvf 161 7 T T NNP cord-344988-09vpehvf 161 8 cell cell NN cord-344988-09vpehvf 161 9 activation activation NN cord-344988-09vpehvf 161 10 or or CC cord-344988-09vpehvf 161 11 alteration alteration NN cord-344988-09vpehvf 161 12 of of IN cord-344988-09vpehvf 161 13 lymphokine lymphokine NN cord-344988-09vpehvf 161 14 production production NN cord-344988-09vpehvf 161 15 , , , cord-344988-09vpehvf 161 16 which which WDT cord-344988-09vpehvf 161 17 in in IN cord-344988-09vpehvf 161 18 turn turn NN cord-344988-09vpehvf 161 19 may may MD cord-344988-09vpehvf 161 20 activate activate VB cord-344988-09vpehvf 161 21 macrophages macrophage NNS cord-344988-09vpehvf 161 22 to to TO cord-344988-09vpehvf 161 23 promote promote VB cord-344988-09vpehvf 161 24 bacterial bacterial JJ cord-344988-09vpehvf 161 25 clearance clearance NN cord-344988-09vpehvf 161 26 [ [ -LRB- cord-344988-09vpehvf 161 27 43 43 CD cord-344988-09vpehvf 161 28 ] ] -RRB- cord-344988-09vpehvf 161 29 . . . cord-344988-09vpehvf 162 1 Zinc zinc NN cord-344988-09vpehvf 162 2 can can MD cord-344988-09vpehvf 162 3 induce induce VB cord-344988-09vpehvf 162 4 the the DT cord-344988-09vpehvf 162 5 production production NN cord-344988-09vpehvf 162 6 of of IN cord-344988-09vpehvf 162 7 IFN IFN NNP cord-344988-09vpehvf 162 8 - - HYPH cord-344988-09vpehvf 162 9 γ γ NNP cord-344988-09vpehvf 162 10 in in IN cord-344988-09vpehvf 162 11 human human JJ cord-344988-09vpehvf 162 12 peripheral peripheral JJ cord-344988-09vpehvf 162 13 blood blood NN cord-344988-09vpehvf 162 14 mononuclear mononuclear NN cord-344988-09vpehvf 162 15 cells cell NNS cord-344988-09vpehvf 162 16 [ [ -LRB- cord-344988-09vpehvf 162 17 136 136 CD cord-344988-09vpehvf 162 18 ] ] -RRB- cord-344988-09vpehvf 162 19 . . . cord-344988-09vpehvf 163 1 Furthermore furthermore RB cord-344988-09vpehvf 163 2 , , , cord-344988-09vpehvf 163 3 zinc zinc NN cord-344988-09vpehvf 163 4 deficiency deficiency NN cord-344988-09vpehvf 163 5 leads lead VBZ cord-344988-09vpehvf 163 6 to to IN cord-344988-09vpehvf 163 7 a a DT cord-344988-09vpehvf 163 8 TH2 TH2 NNP cord-344988-09vpehvf 163 9 shift shift NN cord-344988-09vpehvf 163 10 , , , cord-344988-09vpehvf 163 11 which which WDT cord-344988-09vpehvf 163 12 is be VBZ cord-344988-09vpehvf 163 13 mainly mainly RB cord-344988-09vpehvf 163 14 characterized characterize VBN cord-344988-09vpehvf 163 15 by by IN cord-344988-09vpehvf 163 16 a a DT cord-344988-09vpehvf 163 17 reduction reduction NN cord-344988-09vpehvf 163 18 of of IN cord-344988-09vpehvf 163 19 IL-2 IL-2 NNP cord-344988-09vpehvf 163 20 and and CC cord-344988-09vpehvf 163 21 IFN IFN NNP cord-344988-09vpehvf 163 22 - - HYPH cord-344988-09vpehvf 163 23 γ γ NNP cord-344988-09vpehvf 163 24 [ [ -LRB- cord-344988-09vpehvf 163 25 10 10 CD cord-344988-09vpehvf 163 26 , , , cord-344988-09vpehvf 163 27 20 20 CD cord-344988-09vpehvf 163 28 , , , cord-344988-09vpehvf 163 29 117 117 CD cord-344988-09vpehvf 163 30 ] ] -RRB- cord-344988-09vpehvf 163 31 . . . cord-344988-09vpehvf 164 1 It -PRON- PRP cord-344988-09vpehvf 164 2 was be VBD cord-344988-09vpehvf 164 3 also also RB cord-344988-09vpehvf 164 4 reported report VBN cord-344988-09vpehvf 164 5 that that IN cord-344988-09vpehvf 164 6 zinc zinc NN cord-344988-09vpehvf 164 7 promotes promote VBZ cord-344988-09vpehvf 164 8 a a DT cord-344988-09vpehvf 164 9 TH1 TH1 NNP cord-344988-09vpehvf 164 10 immune immune JJ cord-344988-09vpehvf 164 11 response response NN cord-344988-09vpehvf 164 12 by by IN cord-344988-09vpehvf 164 13 augmenting augment VBG cord-344988-09vpehvf 164 14 the the DT cord-344988-09vpehvf 164 15 gene gene NN cord-344988-09vpehvf 164 16 expression expression NN cord-344988-09vpehvf 164 17 of of IN cord-344988-09vpehvf 164 18 IL-2 IL-2 NNP cord-344988-09vpehvf 164 19 and and CC cord-344988-09vpehvf 164 20 IFN IFN NNP cord-344988-09vpehvf 164 21 - - HYPH cord-344988-09vpehvf 164 22 γ γ NNP cord-344988-09vpehvf 164 23 [ [ -LRB- cord-344988-09vpehvf 164 24 8 8 CD cord-344988-09vpehvf 164 25 ] ] -RRB- cord-344988-09vpehvf 164 26 . . . cord-344988-09vpehvf 165 1 Zinc zinc NN cord-344988-09vpehvf 165 2 supplementation supplementation NN cord-344988-09vpehvf 165 3 has have VBZ cord-344988-09vpehvf 165 4 also also RB cord-344988-09vpehvf 165 5 been be VBN cord-344988-09vpehvf 165 6 investigated investigate VBN cord-344988-09vpehvf 165 7 against against IN cord-344988-09vpehvf 165 8 acute acute JJ cord-344988-09vpehvf 165 9 lower low JJR cord-344988-09vpehvf 165 10 respiratory respiratory JJ cord-344988-09vpehvf 165 11 infection infection NN cord-344988-09vpehvf 165 12 . . . cord-344988-09vpehvf 166 1 Two two CD cord-344988-09vpehvf 166 2 studies study NNS cord-344988-09vpehvf 166 3 reported report VBD cord-344988-09vpehvf 166 4 decreased decrease VBD cord-344988-09vpehvf 166 5 episodes episode NNS cord-344988-09vpehvf 166 6 of of IN cord-344988-09vpehvf 166 7 infection infection NN cord-344988-09vpehvf 166 8 [ [ -LRB- cord-344988-09vpehvf 166 9 141 141 CD cord-344988-09vpehvf 166 10 ] ] -RRB- cord-344988-09vpehvf 166 11 and and CC cord-344988-09vpehvf 166 12 increased increase VBN cord-344988-09vpehvf 166 13 recovery recovery NN cord-344988-09vpehvf 166 14 rates rate NNS cord-344988-09vpehvf 166 15 from from IN cord-344988-09vpehvf 166 16 illness illness NN cord-344988-09vpehvf 166 17 and and CC cord-344988-09vpehvf 166 18 fever fever NN cord-344988-09vpehvf 166 19 after after IN cord-344988-09vpehvf 166 20 zinc zinc NN cord-344988-09vpehvf 166 21 therapy therapy NN cord-344988-09vpehvf 166 22 [ [ -LRB- cord-344988-09vpehvf 166 23 85 85 CD cord-344988-09vpehvf 166 24 ] ] -RRB- cord-344988-09vpehvf 166 25 , , , cord-344988-09vpehvf 166 26 whereby whereby WRB cord-344988-09vpehvf 166 27 the the DT cord-344988-09vpehvf 166 28 effect effect NN cord-344988-09vpehvf 166 29 in in IN cord-344988-09vpehvf 166 30 the the DT cord-344988-09vpehvf 166 31 latter latter JJ cord-344988-09vpehvf 166 32 study study NN cord-344988-09vpehvf 166 33 was be VBD cord-344988-09vpehvf 166 34 only only RB cord-344988-09vpehvf 166 35 significant significant JJ cord-344988-09vpehvf 166 36 in in IN cord-344988-09vpehvf 166 37 boys boy NNS cord-344988-09vpehvf 166 38 . . . cord-344988-09vpehvf 167 1 Lower low JJR cord-344988-09vpehvf 167 2 respiratory respiratory JJ cord-344988-09vpehvf 167 3 infection infection NN cord-344988-09vpehvf 167 4 may may MD cord-344988-09vpehvf 167 5 be be VB cord-344988-09vpehvf 167 6 caused cause VBN cord-344988-09vpehvf 167 7 by by IN cord-344988-09vpehvf 167 8 different different JJ cord-344988-09vpehvf 167 9 bacterial bacterial JJ cord-344988-09vpehvf 167 10 or or CC cord-344988-09vpehvf 167 11 viral viral JJ cord-344988-09vpehvf 167 12 pathogens pathogen NNS cord-344988-09vpehvf 167 13 , , , cord-344988-09vpehvf 167 14 the the DT cord-344988-09vpehvf 167 15 nature nature NN cord-344988-09vpehvf 167 16 of of IN cord-344988-09vpehvf 167 17 which which WDT cord-344988-09vpehvf 167 18 was be VBD cord-344988-09vpehvf 167 19 not not RB cord-344988-09vpehvf 167 20 investigated investigate VBN cord-344988-09vpehvf 167 21 in in IN cord-344988-09vpehvf 167 22 these these DT cord-344988-09vpehvf 167 23 studies study NNS cord-344988-09vpehvf 167 24 . . . cord-344988-09vpehvf 168 1 Hence hence RB cord-344988-09vpehvf 168 2 it -PRON- PRP cord-344988-09vpehvf 168 3 can can MD cord-344988-09vpehvf 168 4 be be VB cord-344988-09vpehvf 168 5 concluded conclude VBN cord-344988-09vpehvf 168 6 that that IN cord-344988-09vpehvf 168 7 zinc zinc NN cord-344988-09vpehvf 168 8 treatment treatment NN cord-344988-09vpehvf 168 9 reduces reduce VBZ cord-344988-09vpehvf 168 10 the the DT cord-344988-09vpehvf 168 11 symptoms symptom NNS cord-344988-09vpehvf 168 12 , , , cord-344988-09vpehvf 168 13 but but CC cord-344988-09vpehvf 168 14 an an DT cord-344988-09vpehvf 168 15 effect effect NN cord-344988-09vpehvf 168 16 of of IN cord-344988-09vpehvf 168 17 zinc zinc NN cord-344988-09vpehvf 168 18 on on IN cord-344988-09vpehvf 168 19 the the DT cord-344988-09vpehvf 168 20 immune immune JJ cord-344988-09vpehvf 168 21 response response NN cord-344988-09vpehvf 168 22 against against IN cord-344988-09vpehvf 168 23 the the DT cord-344988-09vpehvf 168 24 underlying underlie VBG cord-344988-09vpehvf 168 25 pathogens pathogen NNS cord-344988-09vpehvf 168 26 can can MD cord-344988-09vpehvf 168 27 not not RB cord-344988-09vpehvf 168 28 be be VB cord-344988-09vpehvf 168 29 concluded conclude VBN cord-344988-09vpehvf 168 30 from from IN cord-344988-09vpehvf 168 31 these these DT cord-344988-09vpehvf 168 32 data datum NNS cord-344988-09vpehvf 168 33 . . . cord-344988-09vpehvf 169 1 A a DT cord-344988-09vpehvf 169 2 pooled pool VBN cord-344988-09vpehvf 169 3 analysis analysis NN cord-344988-09vpehvf 169 4 of of IN cord-344988-09vpehvf 169 5 four four CD cord-344988-09vpehvf 169 6 trials trial NNS cord-344988-09vpehvf 169 7 in in IN cord-344988-09vpehvf 169 8 which which WDT cord-344988-09vpehvf 169 9 continuous continuous JJ cord-344988-09vpehvf 169 10 supplementation supplementation NN cord-344988-09vpehvf 169 11 was be VBD cord-344988-09vpehvf 169 12 investigated investigate VBN cord-344988-09vpehvf 169 13 confirmed confirm VBD cord-344988-09vpehvf 169 14 that that IN cord-344988-09vpehvf 169 15 zinc zinc NN cord-344988-09vpehvf 169 16 is be VBZ cord-344988-09vpehvf 169 17 efficient efficient JJ cord-344988-09vpehvf 169 18 for for IN cord-344988-09vpehvf 169 19 the the DT cord-344988-09vpehvf 169 20 prevention prevention NN cord-344988-09vpehvf 169 21 of of IN cord-344988-09vpehvf 169 22 pneumonia pneumonia NN cord-344988-09vpehvf 169 23 . . . cord-344988-09vpehvf 170 1 Here here RB cord-344988-09vpehvf 170 2 , , , cord-344988-09vpehvf 170 3 zinc zinc NN cord-344988-09vpehvf 170 4 supplementation supplementation NN cord-344988-09vpehvf 170 5 reduced reduce VBD cord-344988-09vpehvf 170 6 the the DT cord-344988-09vpehvf 170 7 incidence incidence NN cord-344988-09vpehvf 170 8 of of IN cord-344988-09vpehvf 170 9 pneumonia pneumonia NN cord-344988-09vpehvf 170 10 in in IN cord-344988-09vpehvf 170 11 children child NNS cord-344988-09vpehvf 170 12 in in IN cord-344988-09vpehvf 170 13 developing develop VBG cord-344988-09vpehvf 170 14 countries country NNS cord-344988-09vpehvf 170 15 by by IN cord-344988-09vpehvf 170 16 41 41 CD cord-344988-09vpehvf 170 17 % % NN cord-344988-09vpehvf 170 18 [ [ -LRB- cord-344988-09vpehvf 170 19 14 14 CD cord-344988-09vpehvf 170 20 ] ] -RRB- cord-344988-09vpehvf 170 21 . . . cord-344988-09vpehvf 171 1 Pneumonia pneumonia NN cord-344988-09vpehvf 171 2 is be VBZ cord-344988-09vpehvf 171 3 a a DT cord-344988-09vpehvf 171 4 major major JJ cord-344988-09vpehvf 171 5 factor factor NN cord-344988-09vpehvf 171 6 of of IN cord-344988-09vpehvf 171 7 childhood childhood NN cord-344988-09vpehvf 171 8 mortality mortality NN cord-344988-09vpehvf 171 9 ; ; : cord-344988-09vpehvf 171 10 it -PRON- PRP cord-344988-09vpehvf 171 11 accounts account VBZ cord-344988-09vpehvf 171 12 for for IN cord-344988-09vpehvf 171 13 approximately approximately RB cord-344988-09vpehvf 171 14 20 20 CD cord-344988-09vpehvf 171 15 % % NN cord-344988-09vpehvf 171 16 of of IN cord-344988-09vpehvf 171 17 childhood childhood NN cord-344988-09vpehvf 171 18 deaths death NNS cord-344988-09vpehvf 171 19 in in IN cord-344988-09vpehvf 171 20 developing develop VBG cord-344988-09vpehvf 171 21 countries country NNS cord-344988-09vpehvf 171 22 [ [ -LRB- cord-344988-09vpehvf 171 23 175 175 CD cord-344988-09vpehvf 171 24 ] ] -RRB- cord-344988-09vpehvf 171 25 , , , cord-344988-09vpehvf 171 26 making make VBG cord-344988-09vpehvf 171 27 zinc zinc NN cord-344988-09vpehvf 171 28 supplementation supplementation NN cord-344988-09vpehvf 171 29 a a DT cord-344988-09vpehvf 171 30 promising promising JJ cord-344988-09vpehvf 171 31 approach approach NN cord-344988-09vpehvf 171 32 for for IN cord-344988-09vpehvf 171 33 a a DT cord-344988-09vpehvf 171 34 significant significant JJ cord-344988-09vpehvf 171 35 reduction reduction NN cord-344988-09vpehvf 171 36 in in IN cord-344988-09vpehvf 171 37 childhood childhood NN cord-344988-09vpehvf 171 38 mortality mortality NN cord-344988-09vpehvf 171 39 . . . cord-344988-09vpehvf 172 1 In in IN cord-344988-09vpehvf 172 2 addition addition NN cord-344988-09vpehvf 172 3 , , , cord-344988-09vpehvf 172 4 a a DT cord-344988-09vpehvf 172 5 recent recent JJ cord-344988-09vpehvf 172 6 study study NN cord-344988-09vpehvf 172 7 indicates indicate VBZ cord-344988-09vpehvf 172 8 that that IN cord-344988-09vpehvf 172 9 zinc zinc NN cord-344988-09vpehvf 172 10 may may MD cord-344988-09vpehvf 172 11 also also RB cord-344988-09vpehvf 172 12 be be VB cord-344988-09vpehvf 172 13 helpful helpful JJ cord-344988-09vpehvf 172 14 for for IN cord-344988-09vpehvf 172 15 the the DT cord-344988-09vpehvf 172 16 elderly elderly JJ cord-344988-09vpehvf 172 17 . . . cord-344988-09vpehvf 173 1 Serum serum NN cord-344988-09vpehvf 173 2 zinc zinc NN cord-344988-09vpehvf 173 3 concentrations concentration NNS cord-344988-09vpehvf 173 4 were be VBD cord-344988-09vpehvf 173 5 negatively negatively RB cord-344988-09vpehvf 173 6 associated associate VBN cord-344988-09vpehvf 173 7 with with IN cord-344988-09vpehvf 173 8 the the DT cord-344988-09vpehvf 173 9 incidence incidence NN cord-344988-09vpehvf 173 10 of of IN cord-344988-09vpehvf 173 11 pneumonia pneumonia NN cord-344988-09vpehvf 173 12 in in IN cord-344988-09vpehvf 173 13 nursing nursing NN cord-344988-09vpehvf 173 14 home home NN cord-344988-09vpehvf 173 15 residents resident NNS cord-344988-09vpehvf 173 16 , , , cord-344988-09vpehvf 173 17 indicating indicate VBG cord-344988-09vpehvf 173 18 that that IN cord-344988-09vpehvf 173 19 zinc zinc NN cord-344988-09vpehvf 173 20 supplementation supplementation NN cord-344988-09vpehvf 173 21 may may MD cord-344988-09vpehvf 173 22 be be VB cord-344988-09vpehvf 173 23 a a DT cord-344988-09vpehvf 173 24 measure measure NN cord-344988-09vpehvf 173 25 to to TO cord-344988-09vpehvf 173 26 prevent prevent VB cord-344988-09vpehvf 173 27 pneumonia pneumonia NN cord-344988-09vpehvf 173 28 in in IN cord-344988-09vpehvf 173 29 the the DT cord-344988-09vpehvf 173 30 elderly elderly JJ cord-344988-09vpehvf 173 31 [ [ -LRB- cord-344988-09vpehvf 173 32 93 93 CD cord-344988-09vpehvf 173 33 ] ] -RRB- cord-344988-09vpehvf 173 34 . . . cord-344988-09vpehvf 174 1 Low low JJ cord-344988-09vpehvf 174 2 gastric gastric JJ cord-344988-09vpehvf 174 3 mucosal mucosal JJ cord-344988-09vpehvf 174 4 zinc zinc NN cord-344988-09vpehvf 174 5 concentrations concentration NNS cord-344988-09vpehvf 174 6 in in IN cord-344988-09vpehvf 174 7 Heliobacter Heliobacter NNP cord-344988-09vpehvf 174 8 pylori pylori NN cord-344988-09vpehvf 174 9 - - HYPH cord-344988-09vpehvf 174 10 infected infect VBN cord-344988-09vpehvf 174 11 patients patient NNS cord-344988-09vpehvf 174 12 were be VBD cord-344988-09vpehvf 174 13 correlated correlate VBN cord-344988-09vpehvf 174 14 with with IN cord-344988-09vpehvf 174 15 the the DT cord-344988-09vpehvf 174 16 severity severity NN cord-344988-09vpehvf 174 17 of of IN cord-344988-09vpehvf 174 18 inflammation inflammation NN cord-344988-09vpehvf 174 19 , , , cord-344988-09vpehvf 174 20 measured measure VBN cord-344988-09vpehvf 174 21 as as IN cord-344988-09vpehvf 174 22 infiltration infiltration NN cord-344988-09vpehvf 174 23 by by IN cord-344988-09vpehvf 174 24 polymorphonuclear polymorphonuclear JJ cord-344988-09vpehvf 174 25 cells cell NNS cord-344988-09vpehvf 174 26 into into IN cord-344988-09vpehvf 174 27 the the DT cord-344988-09vpehvf 174 28 gastric gastric JJ cord-344988-09vpehvf 174 29 mucosa mucosa JJ cord-344988-09vpehvf 174 30 [ [ -LRB- cord-344988-09vpehvf 174 31 144 144 CD cord-344988-09vpehvf 174 32 ] ] -RRB- cord-344988-09vpehvf 174 33 . . . cord-344988-09vpehvf 175 1 Treatment treatment NN cord-344988-09vpehvf 175 2 with with IN cord-344988-09vpehvf 175 3 polaprezinc polaprezinc NN cord-344988-09vpehvf 175 4 ( ( -LRB- cord-344988-09vpehvf 175 5 zinc zinc NN cord-344988-09vpehvf 175 6 L l NN cord-344988-09vpehvf 175 7 - - HYPH cord-344988-09vpehvf 175 8 carnosine carnosine NNP cord-344988-09vpehvf 175 9 ) ) -RRB- cord-344988-09vpehvf 175 10 , , , cord-344988-09vpehvf 175 11 which which WDT cord-344988-09vpehvf 175 12 is be VBZ cord-344988-09vpehvf 175 13 used use VBN cord-344988-09vpehvf 175 14 as as IN cord-344988-09vpehvf 175 15 an an DT cord-344988-09vpehvf 175 16 anti anti JJ cord-344988-09vpehvf 175 17 - - JJ cord-344988-09vpehvf 175 18 ulcer ulcer JJ cord-344988-09vpehvf 175 19 drug drug NN cord-344988-09vpehvf 175 20 in in IN cord-344988-09vpehvf 175 21 Japan Japan NNP cord-344988-09vpehvf 175 22 , , , cord-344988-09vpehvf 175 23 led lead VBD cord-344988-09vpehvf 175 24 to to IN cord-344988-09vpehvf 175 25 an an DT cord-344988-09vpehvf 175 26 improved improved JJ cord-344988-09vpehvf 175 27 cure cure NN cord-344988-09vpehvf 175 28 rate rate NN cord-344988-09vpehvf 175 29 when when WRB cord-344988-09vpehvf 175 30 administered administer VBN cord-344988-09vpehvf 175 31 together together RB cord-344988-09vpehvf 175 32 with with IN cord-344988-09vpehvf 175 33 antimicrobial antimicrobial JJ cord-344988-09vpehvf 175 34 triple triple JJ cord-344988-09vpehvf 175 35 therapy therapy NN cord-344988-09vpehvf 175 36 [ [ -LRB- cord-344988-09vpehvf 175 37 70 70 CD cord-344988-09vpehvf 175 38 ] ] -RRB- cord-344988-09vpehvf 175 39 . . . cord-344988-09vpehvf 176 1 This this DT cord-344988-09vpehvf 176 2 indicates indicate VBZ cord-344988-09vpehvf 176 3 that that IN cord-344988-09vpehvf 176 4 zinc zinc NN cord-344988-09vpehvf 176 5 could could MD cord-344988-09vpehvf 176 6 also also RB cord-344988-09vpehvf 176 7 be be VB cord-344988-09vpehvf 176 8 effective effective JJ cord-344988-09vpehvf 176 9 as as IN cord-344988-09vpehvf 176 10 an an DT cord-344988-09vpehvf 176 11 adjunct adjunct JJ cord-344988-09vpehvf 176 12 therapy therapy NN cord-344988-09vpehvf 176 13 for for IN cord-344988-09vpehvf 176 14 the the DT cord-344988-09vpehvf 176 15 treatment treatment NN cord-344988-09vpehvf 176 16 and and CC cord-344988-09vpehvf 176 17 eradication eradication NN cord-344988-09vpehvf 176 18 of of IN cord-344988-09vpehvf 176 19 H. h. NN cord-344988-09vpehvf 176 20 pylori pylori NN cord-344988-09vpehvf 176 21 infection infection NN cord-344988-09vpehvf 176 22 . . . cord-344988-09vpehvf 177 1 Various various JJ cord-344988-09vpehvf 177 2 zinc zinc NN cord-344988-09vpehvf 177 3 supplementation supplementation NN cord-344988-09vpehvf 177 4 studies study NNS cord-344988-09vpehvf 177 5 dealing deal VBG cord-344988-09vpehvf 177 6 with with IN cord-344988-09vpehvf 177 7 diseases disease NNS cord-344988-09vpehvf 177 8 caused cause VBN cord-344988-09vpehvf 177 9 by by IN cord-344988-09vpehvf 177 10 parasites parasite NNS cord-344988-09vpehvf 177 11 are be VBP cord-344988-09vpehvf 177 12 listed list VBN cord-344988-09vpehvf 177 13 in in IN cord-344988-09vpehvf 177 14 Table Table NNP cord-344988-09vpehvf 177 15 5 5 CD cord-344988-09vpehvf 177 16 . . . cord-344988-09vpehvf 178 1 One one CD cord-344988-09vpehvf 178 2 of of IN cord-344988-09vpehvf 178 3 these these DT cord-344988-09vpehvf 178 4 is be VBZ cord-344988-09vpehvf 178 5 acute acute JJ cord-344988-09vpehvf 178 6 cutaneous cutaneous JJ cord-344988-09vpehvf 178 7 leishmaniasis leishmaniasis NN cord-344988-09vpehvf 178 8 , , , cord-344988-09vpehvf 178 9 induced induce VBN cord-344988-09vpehvf 178 10 by by IN cord-344988-09vpehvf 178 11 different different JJ cord-344988-09vpehvf 178 12 forms form NNS cord-344988-09vpehvf 178 13 of of IN cord-344988-09vpehvf 178 14 Leishmania Leishmania NNP cord-344988-09vpehvf 178 15 . . . cord-344988-09vpehvf 179 1 Patients patient NNS cord-344988-09vpehvf 179 2 with with IN cord-344988-09vpehvf 179 3 cutaneous cutaneous JJ cord-344988-09vpehvf 179 4 , , , cord-344988-09vpehvf 179 5 mucosal mucosal JJ cord-344988-09vpehvf 179 6 , , , cord-344988-09vpehvf 179 7 and and CC cord-344988-09vpehvf 179 8 visceral visceral JJ cord-344988-09vpehvf 179 9 leishmaniasis leishmaniasis NN cord-344988-09vpehvf 179 10 display display NN cord-344988-09vpehvf 179 11 lower low JJR cord-344988-09vpehvf 179 12 plasma plasma NN cord-344988-09vpehvf 179 13 zinc zinc NN cord-344988-09vpehvf 179 14 levels level NNS cord-344988-09vpehvf 179 15 [ [ -LRB- cord-344988-09vpehvf 179 16 161 161 CD cord-344988-09vpehvf 179 17 ] ] -RRB- cord-344988-09vpehvf 179 18 . . . cord-344988-09vpehvf 180 1 As as IN cord-344988-09vpehvf 180 2 a a DT cord-344988-09vpehvf 180 3 result result NN cord-344988-09vpehvf 180 4 of of IN cord-344988-09vpehvf 180 5 zinc zinc NN cord-344988-09vpehvf 180 6 therapy therapy NN cord-344988-09vpehvf 180 7 , , , cord-344988-09vpehvf 180 8 a a DT cord-344988-09vpehvf 180 9 dose dose NN cord-344988-09vpehvf 180 10 -- -- : cord-344988-09vpehvf 180 11 dependent dependent JJ cord-344988-09vpehvf 180 12 decrease decrease NN cord-344988-09vpehvf 180 13 in in IN cord-344988-09vpehvf 180 14 erythemas erythemas NN cord-344988-09vpehvf 180 15 and and CC cord-344988-09vpehvf 180 16 size size NN cord-344988-09vpehvf 180 17 of of IN cord-344988-09vpehvf 180 18 induration induration NN cord-344988-09vpehvf 180 19 and and CC cord-344988-09vpehvf 180 20 an an DT cord-344988-09vpehvf 180 21 increased increase VBN cord-344988-09vpehvf 180 22 cure cure NN cord-344988-09vpehvf 180 23 rate rate NN cord-344988-09vpehvf 180 24 were be VBD cord-344988-09vpehvf 180 25 found find VBN cord-344988-09vpehvf 180 26 [ [ -LRB- cord-344988-09vpehvf 180 27 147 147 CD cord-344988-09vpehvf 180 28 ] ] -RRB- cord-344988-09vpehvf 180 29 . . . cord-344988-09vpehvf 181 1 A a DT cord-344988-09vpehvf 181 2 direct direct JJ cord-344988-09vpehvf 181 3 anti anti JJ cord-344988-09vpehvf 181 4 - - JJ cord-344988-09vpehvf 181 5 leishmanial leishmanial JJ cord-344988-09vpehvf 181 6 effect effect NN cord-344988-09vpehvf 181 7 was be VBD cord-344988-09vpehvf 181 8 shown show VBN cord-344988-09vpehvf 181 9 for for IN cord-344988-09vpehvf 181 10 zinc zinc NN cord-344988-09vpehvf 181 11 which which WDT cord-344988-09vpehvf 181 12 could could MD cord-344988-09vpehvf 181 13 be be VB cord-344988-09vpehvf 181 14 demonstrated demonstrate VBN cord-344988-09vpehvf 181 15 in in IN cord-344988-09vpehvf 181 16 vitro vitro FW cord-344988-09vpehvf 181 17 by by IN cord-344988-09vpehvf 181 18 zinc zinc NN cord-344988-09vpehvf 181 19 - - HYPH cord-344988-09vpehvf 181 20 induced induce VBN cord-344988-09vpehvf 181 21 inhibition inhibition NN cord-344988-09vpehvf 181 22 of of IN cord-344988-09vpehvf 181 23 several several JJ cord-344988-09vpehvf 181 24 enzymes enzyme NNS cord-344988-09vpehvf 181 25 from from IN cord-344988-09vpehvf 181 26 Leishmania Leishmania NNP cord-344988-09vpehvf 181 27 [ [ -LRB- cord-344988-09vpehvf 181 28 5 5 CD cord-344988-09vpehvf 181 29 , , , cord-344988-09vpehvf 181 30 6 6 CD cord-344988-09vpehvf 181 31 ] ] -RRB- cord-344988-09vpehvf 181 32 . . . cord-344988-09vpehvf 182 1 However however RB cord-344988-09vpehvf 182 2 , , , cord-344988-09vpehvf 182 3 the the DT cord-344988-09vpehvf 182 4 lowest low JJS cord-344988-09vpehvf 182 5 concentration concentration NN cord-344988-09vpehvf 182 6 investigated investigate VBN cord-344988-09vpehvf 182 7 in in IN cord-344988-09vpehvf 182 8 the the DT cord-344988-09vpehvf 182 9 assays assay NNS cord-344988-09vpehvf 182 10 was be VBD cord-344988-09vpehvf 182 11 150 150 CD cord-344988-09vpehvf 182 12 µM µm NN cord-344988-09vpehvf 182 13 , , , cord-344988-09vpehvf 182 14 and and CC cord-344988-09vpehvf 182 15 many many JJ cord-344988-09vpehvf 182 16 inhibitions inhibition NNS cord-344988-09vpehvf 182 17 were be VBD cord-344988-09vpehvf 182 18 only only RB cord-344988-09vpehvf 182 19 observed observe VBN cord-344988-09vpehvf 182 20 at at IN cord-344988-09vpehvf 182 21 even even RB cord-344988-09vpehvf 182 22 higher high JJR cord-344988-09vpehvf 182 23 concentrations concentration NNS cord-344988-09vpehvf 182 24 . . . cord-344988-09vpehvf 183 1 Therefore therefore RB cord-344988-09vpehvf 183 2 , , , cord-344988-09vpehvf 183 3 the the DT cord-344988-09vpehvf 183 4 physiological physiological JJ cord-344988-09vpehvf 183 5 relevance relevance NN cord-344988-09vpehvf 183 6 of of IN cord-344988-09vpehvf 183 7 these these DT cord-344988-09vpehvf 183 8 observations observation NNS cord-344988-09vpehvf 183 9 may may MD cord-344988-09vpehvf 183 10 be be VB cord-344988-09vpehvf 183 11 limited limit VBN cord-344988-09vpehvf 183 12 . . . cord-344988-09vpehvf 184 1 Another another DT cord-344988-09vpehvf 184 2 area area NN cord-344988-09vpehvf 184 3 of of IN cord-344988-09vpehvf 184 4 zinc zinc NN cord-344988-09vpehvf 184 5 application application NN cord-344988-09vpehvf 184 6 is be VBZ cord-344988-09vpehvf 184 7 malaria malaria NN cord-344988-09vpehvf 184 8 . . . cord-344988-09vpehvf 185 1 During during IN cord-344988-09vpehvf 185 2 acute acute JJ cord-344988-09vpehvf 185 3 malaria malaria NN cord-344988-09vpehvf 185 4 , , , cord-344988-09vpehvf 185 5 plasma plasma NN cord-344988-09vpehvf 185 6 zinc zinc NN cord-344988-09vpehvf 185 7 levels level NNS cord-344988-09vpehvf 185 8 are be VBP cord-344988-09vpehvf 185 9 reduced reduce VBN cord-344988-09vpehvf 185 10 and and CC cord-344988-09vpehvf 185 11 inversely inversely RB cord-344988-09vpehvf 185 12 correlate correlate VB cord-344988-09vpehvf 185 13 to to IN cord-344988-09vpehvf 185 14 C c NN cord-344988-09vpehvf 185 15 - - HYPH cord-344988-09vpehvf 185 16 reactive reactive JJ cord-344988-09vpehvf 185 17 protein protein NN cord-344988-09vpehvf 185 18 , , , cord-344988-09vpehvf 185 19 indicating indicate VBG cord-344988-09vpehvf 185 20 a a DT cord-344988-09vpehvf 185 21 decrease decrease NN cord-344988-09vpehvf 185 22 of of IN cord-344988-09vpehvf 185 23 zinc zinc NN cord-344988-09vpehvf 185 24 as as IN cord-344988-09vpehvf 185 25 a a DT cord-344988-09vpehvf 185 26 consequence consequence NN cord-344988-09vpehvf 185 27 of of IN cord-344988-09vpehvf 185 28 the the DT cord-344988-09vpehvf 185 29 acute acute JJ cord-344988-09vpehvf 185 30 - - HYPH cord-344988-09vpehvf 185 31 phase phase NN cord-344988-09vpehvf 185 32 response response NN cord-344988-09vpehvf 185 33 [ [ -LRB- cord-344988-09vpehvf 185 34 33 33 CD cord-344988-09vpehvf 185 35 ] ] -RRB- cord-344988-09vpehvf 185 36 . . . cord-344988-09vpehvf 186 1 There there EX cord-344988-09vpehvf 186 2 are be VBP cord-344988-09vpehvf 186 3 some some DT cord-344988-09vpehvf 186 4 studies study NNS cord-344988-09vpehvf 186 5 dealing deal VBG cord-344988-09vpehvf 186 6 with with IN cord-344988-09vpehvf 186 7 the the DT cord-344988-09vpehvf 186 8 usefulness usefulness NN cord-344988-09vpehvf 186 9 of of IN cord-344988-09vpehvf 186 10 zinc zinc NN cord-344988-09vpehvf 186 11 supplementation supplementation NN cord-344988-09vpehvf 186 12 against against IN cord-344988-09vpehvf 186 13 this this DT cord-344988-09vpehvf 186 14 disease disease NN cord-344988-09vpehvf 186 15 , , , cord-344988-09vpehvf 186 16 with with IN cord-344988-09vpehvf 186 17 contradictory contradictory JJ cord-344988-09vpehvf 186 18 results result NNS cord-344988-09vpehvf 186 19 . . . cord-344988-09vpehvf 187 1 Two two CD cord-344988-09vpehvf 187 2 papers paper NNS cord-344988-09vpehvf 187 3 reported report VBD cord-344988-09vpehvf 187 4 beneficial beneficial JJ cord-344988-09vpehvf 187 5 effects effect NNS cord-344988-09vpehvf 187 6 , , , cord-344988-09vpehvf 187 7 including include VBG cord-344988-09vpehvf 187 8 a a DT cord-344988-09vpehvf 187 9 reduced reduce VBN cord-344988-09vpehvf 187 10 incidence incidence NN cord-344988-09vpehvf 187 11 in in IN cord-344988-09vpehvf 187 12 P. P. NNP cord-344988-09vpehvf 187 13 falciparum falciparum NN cord-344988-09vpehvf 187 14 - - HYPH cord-344988-09vpehvf 187 15 mediated mediate VBN cord-344988-09vpehvf 187 16 febrile febrile JJ cord-344988-09vpehvf 187 17 episodes episode NNS cord-344988-09vpehvf 187 18 [ [ -LRB- cord-344988-09vpehvf 187 19 145 145 CD cord-344988-09vpehvf 187 20 ] ] -RRB- cord-344988-09vpehvf 187 21 and and CC cord-344988-09vpehvf 187 22 a a DT cord-344988-09vpehvf 187 23 trend trend NN cord-344988-09vpehvf 187 24 toward toward IN cord-344988-09vpehvf 187 25 fewer few JJR cord-344988-09vpehvf 187 26 malaria malaria NN cord-344988-09vpehvf 187 27 episodes episode NNS cord-344988-09vpehvf 187 28 [ [ -LRB- cord-344988-09vpehvf 187 29 9 9 CD cord-344988-09vpehvf 187 30 ] ] -RRB- cord-344988-09vpehvf 187 31 . . . cord-344988-09vpehvf 188 1 However however RB cord-344988-09vpehvf 188 2 , , , cord-344988-09vpehvf 188 3 the the DT cord-344988-09vpehvf 188 4 lastmentioned lastmentioned JJ cord-344988-09vpehvf 188 5 study study NN cord-344988-09vpehvf 188 6 was be VBD cord-344988-09vpehvf 188 7 statistically statistically RB cord-344988-09vpehvf 188 8 not not RB cord-344988-09vpehvf 188 9 significant significant JJ cord-344988-09vpehvf 188 10 and and CC cord-344988-09vpehvf 188 11 found find VBD cord-344988-09vpehvf 188 12 no no DT cord-344988-09vpehvf 188 13 zinc zinc NN cord-344988-09vpehvf 188 14 - - HYPH cord-344988-09vpehvf 188 15 mediated mediate VBN cord-344988-09vpehvf 188 16 effect effect NN cord-344988-09vpehvf 188 17 on on IN cord-344988-09vpehvf 188 18 diarrhea diarrhea NN cord-344988-09vpehvf 188 19 and and CC cord-344988-09vpehvf 188 20 respiratory respiratory JJ cord-344988-09vpehvf 188 21 infection infection NN cord-344988-09vpehvf 188 22 [ [ -LRB- cord-344988-09vpehvf 188 23 9 9 CD cord-344988-09vpehvf 188 24 ] ] -RRB- cord-344988-09vpehvf 188 25 . . . cord-344988-09vpehvf 189 1 Two two CD cord-344988-09vpehvf 189 2 other other JJ cord-344988-09vpehvf 189 3 studies study NNS cord-344988-09vpehvf 189 4 also also RB cord-344988-09vpehvf 189 5 found find VBD cord-344988-09vpehvf 189 6 no no DT cord-344988-09vpehvf 189 7 effect effect NN cord-344988-09vpehvf 189 8 of of IN cord-344988-09vpehvf 189 9 zinc zinc NN cord-344988-09vpehvf 189 10 on on IN cord-344988-09vpehvf 189 11 the the DT cord-344988-09vpehvf 189 12 incidence incidence NN cord-344988-09vpehvf 189 13 of of IN cord-344988-09vpehvf 189 14 malaria malaria NN cord-344988-09vpehvf 189 15 , , , cord-344988-09vpehvf 189 16 but but CC cord-344988-09vpehvf 189 17 demonstrated demonstrate VBD cord-344988-09vpehvf 189 18 that that IN cord-344988-09vpehvf 189 19 zinc zinc NN cord-344988-09vpehvf 189 20 supplementation supplementation NN cord-344988-09vpehvf 189 21 decreased decrease VBD cord-344988-09vpehvf 189 22 morbidity morbidity NN cord-344988-09vpehvf 189 23 from from IN cord-344988-09vpehvf 189 24 diarrhea diarrhea NN cord-344988-09vpehvf 189 25 [ [ -LRB- cord-344988-09vpehvf 189 26 98 98 CD cord-344988-09vpehvf 189 27 , , , cord-344988-09vpehvf 189 28 128 128 CD cord-344988-09vpehvf 189 29 ] ] -RRB- cord-344988-09vpehvf 189 30 . . . cord-344988-09vpehvf 190 1 In in IN cord-344988-09vpehvf 190 2 addition addition NN cord-344988-09vpehvf 190 3 to to IN cord-344988-09vpehvf 190 4 these these DT cord-344988-09vpehvf 190 5 trials trial NNS cord-344988-09vpehvf 190 6 , , , cord-344988-09vpehvf 190 7 which which WDT cord-344988-09vpehvf 190 8 focused focus VBD cord-344988-09vpehvf 190 9 on on IN cord-344988-09vpehvf 190 10 the the DT cord-344988-09vpehvf 190 11 prevention prevention NN cord-344988-09vpehvf 190 12 of of IN cord-344988-09vpehvf 190 13 malaria malaria NN cord-344988-09vpehvf 190 14 by by IN cord-344988-09vpehvf 190 15 zinc zinc NN cord-344988-09vpehvf 190 16 supplementation supplementation NN cord-344988-09vpehvf 190 17 , , , cord-344988-09vpehvf 190 18 the the DT cord-344988-09vpehvf 190 19 therapeutic therapeutic JJ cord-344988-09vpehvf 190 20 value value NN cord-344988-09vpehvf 190 21 of of IN cord-344988-09vpehvf 190 22 zinc zinc NN cord-344988-09vpehvf 190 23 as as IN cord-344988-09vpehvf 190 24 an an DT cord-344988-09vpehvf 190 25 adjunct adjunct NN cord-344988-09vpehvf 190 26 to to IN cord-344988-09vpehvf 190 27 standard standard JJ cord-344988-09vpehvf 190 28 chemotherapy chemotherapy NN cord-344988-09vpehvf 190 29 for for IN cord-344988-09vpehvf 190 30 the the DT cord-344988-09vpehvf 190 31 treatment treatment NN cord-344988-09vpehvf 190 32 of of IN cord-344988-09vpehvf 190 33 acute acute JJ cord-344988-09vpehvf 190 34 malaria malaria NN cord-344988-09vpehvf 190 35 has have VBZ cord-344988-09vpehvf 190 36 also also RB cord-344988-09vpehvf 190 37 been be VBN cord-344988-09vpehvf 190 38 investigated investigate VBN cord-344988-09vpehvf 190 39 in in IN cord-344988-09vpehvf 190 40 a a DT cord-344988-09vpehvf 190 41 large large JJ cord-344988-09vpehvf 190 42 multicenter multicenter JJ cord-344988-09vpehvf 190 43 study study NN cord-344988-09vpehvf 190 44 in in IN cord-344988-09vpehvf 190 45 Ecuador Ecuador NNP cord-344988-09vpehvf 190 46 and and CC cord-344988-09vpehvf 190 47 four four CD cord-344988-09vpehvf 190 48 African african JJ cord-344988-09vpehvf 190 49 countries country NNS cord-344988-09vpehvf 190 50 [ [ -LRB- cord-344988-09vpehvf 190 51 177 177 CD cord-344988-09vpehvf 190 52 ] ] -RRB- cord-344988-09vpehvf 190 53 . . . cord-344988-09vpehvf 191 1 Here here RB cord-344988-09vpehvf 191 2 , , , cord-344988-09vpehvf 191 3 no no DT cord-344988-09vpehvf 191 4 effect effect NN cord-344988-09vpehvf 191 5 of of IN cord-344988-09vpehvf 191 6 zinc zinc NN cord-344988-09vpehvf 191 7 was be VBD cord-344988-09vpehvf 191 8 found find VBN cord-344988-09vpehvf 191 9 on on IN cord-344988-09vpehvf 191 10 any any DT cord-344988-09vpehvf 191 11 of of IN cord-344988-09vpehvf 191 12 the the DT cord-344988-09vpehvf 191 13 parameters parameter NNS cord-344988-09vpehvf 191 14 that that WDT cord-344988-09vpehvf 191 15 were be VBD cord-344988-09vpehvf 191 16 investigated investigate VBN cord-344988-09vpehvf 191 17 . . . cord-344988-09vpehvf 192 1 With with IN cord-344988-09vpehvf 192 2 regard regard NN cord-344988-09vpehvf 192 3 to to IN cord-344988-09vpehvf 192 4 a a DT cord-344988-09vpehvf 192 5 potential potential JJ cord-344988-09vpehvf 192 6 mechanism mechanism NN cord-344988-09vpehvf 192 7 , , , cord-344988-09vpehvf 192 8 it -PRON- PRP cord-344988-09vpehvf 192 9 seems seem VBZ cord-344988-09vpehvf 192 10 remarkable remarkable JJ cord-344988-09vpehvf 192 11 that that IN cord-344988-09vpehvf 192 12 zinc zinc NN cord-344988-09vpehvf 192 13 protects protect VBZ cord-344988-09vpehvf 192 14 against against IN cord-344988-09vpehvf 192 15 morbidity morbidity NN cord-344988-09vpehvf 192 16 mediated mediate VBN cord-344988-09vpehvf 192 17 by by IN cord-344988-09vpehvf 192 18 P. P. NNP cord-344988-09vpehvf 192 19 falciparum falciparum NN cord-344988-09vpehvf 192 20 , , , cord-344988-09vpehvf 192 21 but but CC cord-344988-09vpehvf 192 22 not not RB cord-344988-09vpehvf 192 23 by by IN cord-344988-09vpehvf 192 24 P. P. NNP cord-344988-09vpehvf 192 25 vivax vivax NN cord-344988-09vpehvf 192 26 . . . cord-344988-09vpehvf 193 1 This this DT cord-344988-09vpehvf 193 2 selectivity selectivity NN cord-344988-09vpehvf 193 3 indicates indicate VBZ cord-344988-09vpehvf 193 4 that that IN cord-344988-09vpehvf 193 5 zinc zinc NN cord-344988-09vpehvf 193 6 may may MD cord-344988-09vpehvf 193 7 act act VB cord-344988-09vpehvf 193 8 on on IN cord-344988-09vpehvf 193 9 a a DT cord-344988-09vpehvf 193 10 specific specific JJ cord-344988-09vpehvf 193 11 pathogenic pathogenic JJ cord-344988-09vpehvf 193 12 process process NN cord-344988-09vpehvf 193 13 , , , cord-344988-09vpehvf 193 14 for for IN cord-344988-09vpehvf 193 15 example example NN cord-344988-09vpehvf 193 16 the the DT cord-344988-09vpehvf 193 17 sequestration sequestration NN cord-344988-09vpehvf 193 18 of of IN cord-344988-09vpehvf 193 19 mature mature JJ cord-344988-09vpehvf 193 20 parasite parasite NN cord-344988-09vpehvf 193 21 - - HYPH cord-344988-09vpehvf 193 22 infected infect VBN cord-344988-09vpehvf 193 23 erythrocytes erythrocyte NNS cord-344988-09vpehvf 193 24 in in IN cord-344988-09vpehvf 193 25 the the DT cord-344988-09vpehvf 193 26 microvasculature microvasculature NN cord-344988-09vpehvf 193 27 , , , cord-344988-09vpehvf 193 28 which which WDT cord-344988-09vpehvf 193 29 is be VBZ cord-344988-09vpehvf 193 30 associated associate VBN cord-344988-09vpehvf 193 31 only only RB cord-344988-09vpehvf 193 32 with with IN cord-344988-09vpehvf 193 33 P. p. NN cord-344988-09vpehvf 193 34 falciparum falciparum NN cord-344988-09vpehvf 193 35 [ [ -LRB- cord-344988-09vpehvf 193 36 145 145 CD cord-344988-09vpehvf 193 37 ] ] -RRB- cord-344988-09vpehvf 193 38 . . . cord-344988-09vpehvf 194 1 Table table NN cord-344988-09vpehvf 194 2 6 6 CD cord-344988-09vpehvf 194 3 summarizes summarize VBZ cord-344988-09vpehvf 194 4 zinc zinc NN cord-344988-09vpehvf 194 5 supplementation supplementation NN cord-344988-09vpehvf 194 6 studies study NNS cord-344988-09vpehvf 194 7 in in IN cord-344988-09vpehvf 194 8 patients patient NNS cord-344988-09vpehvf 194 9 who who WP cord-344988-09vpehvf 194 10 suffer suffer VBP cord-344988-09vpehvf 194 11 from from IN cord-344988-09vpehvf 194 12 one one CD cord-344988-09vpehvf 194 13 of of IN cord-344988-09vpehvf 194 14 two two CD cord-344988-09vpehvf 194 15 autoimmune autoimmune JJ cord-344988-09vpehvf 194 16 diseases disease NNS cord-344988-09vpehvf 194 17 , , , cord-344988-09vpehvf 194 18 namely namely RB cord-344988-09vpehvf 194 19 rheumatoid rheumatoid JJ cord-344988-09vpehvf 194 20 arthritis arthritis NN cord-344988-09vpehvf 194 21 ( ( -LRB- cord-344988-09vpehvf 194 22 RA RA NNP cord-344988-09vpehvf 194 23 ) ) -RRB- cord-344988-09vpehvf 194 24 and and CC cord-344988-09vpehvf 194 25 type type NN cord-344988-09vpehvf 194 26 I -PRON- PRP cord-344988-09vpehvf 194 27 or or CC cord-344988-09vpehvf 194 28 insulin insulin NN cord-344988-09vpehvf 194 29 - - HYPH cord-344988-09vpehvf 194 30 dependent dependent JJ cord-344988-09vpehvf 194 31 diabetes diabetes NN cord-344988-09vpehvf 194 32 mellitus mellitus NN cord-344988-09vpehvf 194 33 ( ( -LRB- cord-344988-09vpehvf 194 34 IDDM IDDM NNP cord-344988-09vpehvf 194 35 ) ) -RRB- cord-344988-09vpehvf 194 36 . . . cord-344988-09vpehvf 195 1 When when WRB cord-344988-09vpehvf 195 2 the the DT cord-344988-09vpehvf 195 3 effect effect NN cord-344988-09vpehvf 195 4 of of IN cord-344988-09vpehvf 195 5 zinc zinc NN cord-344988-09vpehvf 195 6 supplementation supplementation NN cord-344988-09vpehvf 195 7 on on IN cord-344988-09vpehvf 195 8 RA RA NNP cord-344988-09vpehvf 195 9 patients patient NNS cord-344988-09vpehvf 195 10 was be VBD cord-344988-09vpehvf 195 11 investigated investigate VBN cord-344988-09vpehvf 195 12 , , , cord-344988-09vpehvf 195 13 one one CD cord-344988-09vpehvf 195 14 study study NN cord-344988-09vpehvf 195 15 detected detect VBD cord-344988-09vpehvf 195 16 positive positive JJ cord-344988-09vpehvf 195 17 changes change NNS cord-344988-09vpehvf 195 18 after after IN cord-344988-09vpehvf 195 19 zinc zinc NN cord-344988-09vpehvf 195 20 therapy therapy NN cord-344988-09vpehvf 195 21 regarding regard VBG cord-344988-09vpehvf 195 22 joint joint JJ cord-344988-09vpehvf 195 23 swelling swelling NN cord-344988-09vpehvf 195 24 , , , cord-344988-09vpehvf 195 25 morning morning NN cord-344988-09vpehvf 195 26 stiffness stiffness NN cord-344988-09vpehvf 195 27 , , , cord-344988-09vpehvf 195 28 and and CC cord-344988-09vpehvf 195 29 walking walk VBG cord-344988-09vpehvf 195 30 time time NN cord-344988-09vpehvf 195 31 [ [ -LRB- cord-344988-09vpehvf 195 32 148 148 CD cord-344988-09vpehvf 195 33 ] ] -RRB- cord-344988-09vpehvf 195 34 . . . cord-344988-09vpehvf 196 1 However however RB cord-344988-09vpehvf 196 2 , , , cord-344988-09vpehvf 196 3 two two CD cord-344988-09vpehvf 196 4 other other JJ cord-344988-09vpehvf 196 5 studies study NNS cord-344988-09vpehvf 196 6 found find VBD cord-344988-09vpehvf 196 7 no no DT cord-344988-09vpehvf 196 8 antirheumatic antirheumatic JJ cord-344988-09vpehvf 196 9 activity activity NN cord-344988-09vpehvf 196 10 of of IN cord-344988-09vpehvf 196 11 zinc zinc NN cord-344988-09vpehvf 196 12 [ [ -LRB- cord-344988-09vpehvf 196 13 91 91 CD cord-344988-09vpehvf 196 14 , , , cord-344988-09vpehvf 196 15 126 126 CD cord-344988-09vpehvf 196 16 ] ] -RRB- cord-344988-09vpehvf 196 17 . . . cord-344988-09vpehvf 197 1 Conversely conversely RB cord-344988-09vpehvf 197 2 , , , cord-344988-09vpehvf 197 3 it -PRON- PRP cord-344988-09vpehvf 197 4 was be VBD cord-344988-09vpehvf 197 5 shown show VBN cord-344988-09vpehvf 197 6 that that IN cord-344988-09vpehvf 197 7 zinc zinc NN cord-344988-09vpehvf 197 8 supplementation supplementation NN cord-344988-09vpehvf 197 9 modulated modulate VBD cord-344988-09vpehvf 197 10 ex ex FW cord-344988-09vpehvf 197 11 vivo vivo NN cord-344988-09vpehvf 197 12 phagocytosis phagocytosis NN cord-344988-09vpehvf 197 13 and and CC cord-344988-09vpehvf 197 14 oxidative oxidative JJ cord-344988-09vpehvf 197 15 burst burst NN cord-344988-09vpehvf 197 16 in in IN cord-344988-09vpehvf 197 17 phagocytes phagocyte NNS cord-344988-09vpehvf 197 18 from from IN cord-344988-09vpehvf 197 19 RA RA NNP cord-344988-09vpehvf 197 20 patients patient NNS cord-344988-09vpehvf 197 21 [ [ -LRB- cord-344988-09vpehvf 197 22 62 62 CD cord-344988-09vpehvf 197 23 , , , cord-344988-09vpehvf 197 24 109 109 CD cord-344988-09vpehvf 197 25 ] ] -RRB- cord-344988-09vpehvf 197 26 . . . cord-344988-09vpehvf 198 1 At at IN cord-344988-09vpehvf 198 2 present present NN cord-344988-09vpehvf 198 3 , , , cord-344988-09vpehvf 198 4 these these DT cord-344988-09vpehvf 198 5 contradicting contradict VBG cord-344988-09vpehvf 198 6 data datum NNS cord-344988-09vpehvf 198 7 do do VBP cord-344988-09vpehvf 198 8 not not RB cord-344988-09vpehvf 198 9 allow allow VB cord-344988-09vpehvf 198 10 concluding conclude VBG cord-344988-09vpehvf 198 11 an an DT cord-344988-09vpehvf 198 12 effectiveness effectiveness NN cord-344988-09vpehvf 198 13 of of IN cord-344988-09vpehvf 198 14 zinc zinc NN cord-344988-09vpehvf 198 15 for for IN cord-344988-09vpehvf 198 16 treating treat VBG cord-344988-09vpehvf 198 17 RA RA NNP cord-344988-09vpehvf 198 18 . . . cord-344988-09vpehvf 199 1 Patients patient NNS cord-344988-09vpehvf 199 2 with with IN cord-344988-09vpehvf 199 3 RA RA NNP cord-344988-09vpehvf 199 4 show show NN cord-344988-09vpehvf 199 5 reduced reduced JJ cord-344988-09vpehvf 199 6 serum serum NN cord-344988-09vpehvf 199 7 zinc zinc NN cord-344988-09vpehvf 199 8 levels level NNS cord-344988-09vpehvf 199 9 [ [ -LRB- cord-344988-09vpehvf 199 10 101 101 CD cord-344988-09vpehvf 199 11 , , , cord-344988-09vpehvf 199 12 178 178 CD cord-344988-09vpehvf 199 13 ] ] -RRB- cord-344988-09vpehvf 199 14 , , , cord-344988-09vpehvf 199 15 which which WDT cord-344988-09vpehvf 199 16 may may MD cord-344988-09vpehvf 199 17 be be VB cord-344988-09vpehvf 199 18 due due JJ cord-344988-09vpehvf 199 19 to to IN cord-344988-09vpehvf 199 20 a a DT cord-344988-09vpehvf 199 21 malabsorption malabsorption NN cord-344988-09vpehvf 199 22 of of IN cord-344988-09vpehvf 199 23 zinc zinc NN cord-344988-09vpehvf 199 24 [ [ -LRB- cord-344988-09vpehvf 199 25 99 99 CD cord-344988-09vpehvf 199 26 ] ] -RRB- cord-344988-09vpehvf 199 27 . . . cord-344988-09vpehvf 200 1 A a DT cord-344988-09vpehvf 200 2 way way NN cord-344988-09vpehvf 200 3 in in IN cord-344988-09vpehvf 200 4 which which WDT cord-344988-09vpehvf 200 5 zinc zinc NN cord-344988-09vpehvf 200 6 deficiency deficiency NN cord-344988-09vpehvf 200 7 could could MD cord-344988-09vpehvf 200 8 affect affect VB cord-344988-09vpehvf 200 9 the the DT cord-344988-09vpehvf 200 10 pathogenesis pathogenesis NN cord-344988-09vpehvf 200 11 of of IN cord-344988-09vpehvf 200 12 RA RA NNP cord-344988-09vpehvf 200 13 is be VBZ cord-344988-09vpehvf 200 14 its -PRON- PRP$ cord-344988-09vpehvf 200 15 influence influence NN cord-344988-09vpehvf 200 16 on on IN cord-344988-09vpehvf 200 17 pro pro JJ cord-344988-09vpehvf 200 18 - - JJ cord-344988-09vpehvf 200 19 inflammatory inflammatory JJ cord-344988-09vpehvf 200 20 cytokine cytokine NN cord-344988-09vpehvf 200 21 secretion secretion NN cord-344988-09vpehvf 200 22 . . . cord-344988-09vpehvf 201 1 In in IN cord-344988-09vpehvf 201 2 patients patient NNS cord-344988-09vpehvf 201 3 with with IN cord-344988-09vpehvf 201 4 RA RA NNP cord-344988-09vpehvf 201 5 , , , cord-344988-09vpehvf 201 6 the the DT cord-344988-09vpehvf 201 7 serum serum NN cord-344988-09vpehvf 201 8 zinc zinc NN cord-344988-09vpehvf 201 9 level level NN cord-344988-09vpehvf 201 10 correlates correlate VBZ cord-344988-09vpehvf 201 11 negatively negatively RB cord-344988-09vpehvf 201 12 with with IN cord-344988-09vpehvf 201 13 levels level NNS cord-344988-09vpehvf 201 14 of of IN cord-344988-09vpehvf 201 15 TNF TNF NNP cord-344988-09vpehvf 201 16 - - HYPH cord-344988-09vpehvf 201 17 α α NNP cord-344988-09vpehvf 201 18 and and CC cord-344988-09vpehvf 201 19 IL-1β IL-1β NNP cord-344988-09vpehvf 201 20 as as RB cord-344988-09vpehvf 201 21 well well RB cord-344988-09vpehvf 201 22 as as IN cord-344988-09vpehvf 201 23 parameters parameter NNS cord-344988-09vpehvf 201 24 for for IN cord-344988-09vpehvf 201 25 inflammation inflammation NN cord-344988-09vpehvf 201 26 such such JJ cord-344988-09vpehvf 201 27 as as IN cord-344988-09vpehvf 201 28 acute acute JJ cord-344988-09vpehvf 201 29 - - HYPH cord-344988-09vpehvf 201 30 phase phase NN cord-344988-09vpehvf 201 31 proteins protein NNS cord-344988-09vpehvf 201 32 and and CC cord-344988-09vpehvf 201 33 erythrocyte erythrocyte NN cord-344988-09vpehvf 201 34 sedimentation sedimentation NN cord-344988-09vpehvf 201 35 . . . cord-344988-09vpehvf 202 1 This this DT cord-344988-09vpehvf 202 2 corresponds correspond VBZ cord-344988-09vpehvf 202 3 to to IN cord-344988-09vpehvf 202 4 a a DT cord-344988-09vpehvf 202 5 cellular cellular NN cord-344988-09vpehvf 202 6 in in IN cord-344988-09vpehvf 202 7 vitro vitro FW cord-344988-09vpehvf 202 8 model model NN cord-344988-09vpehvf 202 9 for for IN cord-344988-09vpehvf 202 10 zinc zinc NN cord-344988-09vpehvf 202 11 deficiency deficiency NN cord-344988-09vpehvf 202 12 in in IN cord-344988-09vpehvf 202 13 which which WDT cord-344988-09vpehvf 202 14 the the DT cord-344988-09vpehvf 202 15 levels level NNS cord-344988-09vpehvf 202 16 of of IN cord-344988-09vpehvf 202 17 pro pro JJ cord-344988-09vpehvf 202 18 - - JJ cord-344988-09vpehvf 202 19 inflammatory inflammatory JJ cord-344988-09vpehvf 202 20 cytokines cytokine NNS cord-344988-09vpehvf 202 21 such such JJ cord-344988-09vpehvf 202 22 as as IN cord-344988-09vpehvf 202 23 TNF TNF NNP cord-344988-09vpehvf 202 24 - - HYPH cord-344988-09vpehvf 202 25 α α NNP cord-344988-09vpehvf 202 26 , , , cord-344988-09vpehvf 202 27 IL-1β IL-1β NNP cord-344988-09vpehvf 202 28 , , , cord-344988-09vpehvf 202 29 and and CC cord-344988-09vpehvf 202 30 IL-8 IL-8 NNP cord-344988-09vpehvf 202 31 were be VBD cord-344988-09vpehvf 202 32 increased increase VBN cord-344988-09vpehvf 202 33 [ [ -LRB- cord-344988-09vpehvf 202 34 8 8 CD cord-344988-09vpehvf 202 35 ] ] -RRB- cord-344988-09vpehvf 202 36 , , , cord-344988-09vpehvf 202 37 and and CC cord-344988-09vpehvf 202 38 to to IN cord-344988-09vpehvf 202 39 other other JJ cord-344988-09vpehvf 202 40 observations observation NNS cord-344988-09vpehvf 202 41 demonstrating demonstrate VBG cord-344988-09vpehvf 202 42 that that IN cord-344988-09vpehvf 202 43 monocytic monocytic JJ cord-344988-09vpehvf 202 44 production production NN cord-344988-09vpehvf 202 45 of of IN cord-344988-09vpehvf 202 46 pro pro JJ cord-344988-09vpehvf 202 47 - - JJ cord-344988-09vpehvf 202 48 inflammatory inflammatory JJ cord-344988-09vpehvf 202 49 cytokines cytokine NNS cord-344988-09vpehvf 202 50 is be VBZ cord-344988-09vpehvf 202 51 inhibited inhibit VBN cord-344988-09vpehvf 202 52 by by IN cord-344988-09vpehvf 202 53 zinc zinc NN cord-344988-09vpehvf 202 54 ions ion NNS cord-344988-09vpehvf 202 55 [ [ -LRB- cord-344988-09vpehvf 202 56 164 164 CD cord-344988-09vpehvf 202 57 , , , cord-344988-09vpehvf 202 58 165 165 CD cord-344988-09vpehvf 202 59 ] ] -RRB- cord-344988-09vpehvf 202 60 . . . cord-344988-09vpehvf 203 1 IDDM IDDM NNP cord-344988-09vpehvf 203 2 is be VBZ cord-344988-09vpehvf 203 3 typically typically RB cord-344988-09vpehvf 203 4 accompanied accompany VBN cord-344988-09vpehvf 203 5 by by IN cord-344988-09vpehvf 203 6 a a DT cord-344988-09vpehvf 203 7 loss loss NN cord-344988-09vpehvf 203 8 of of IN cord-344988-09vpehvf 203 9 zinc zinc NN cord-344988-09vpehvf 203 10 due due JJ cord-344988-09vpehvf 203 11 to to IN cord-344988-09vpehvf 203 12 increased increase VBN cord-344988-09vpehvf 203 13 urinary urinary JJ cord-344988-09vpehvf 203 14 excretion excretion NN cord-344988-09vpehvf 203 15 , , , cord-344988-09vpehvf 203 16 resulting result VBG cord-344988-09vpehvf 203 17 in in IN cord-344988-09vpehvf 203 18 a a DT cord-344988-09vpehvf 203 19 decrease decrease NN cord-344988-09vpehvf 203 20 in in IN cord-344988-09vpehvf 203 21 total total JJ cord-344988-09vpehvf 203 22 body body NN cord-344988-09vpehvf 203 23 zinc zinc NN cord-344988-09vpehvf 203 24 . . . cord-344988-09vpehvf 204 1 This this DT cord-344988-09vpehvf 204 2 secondary secondary JJ cord-344988-09vpehvf 204 3 zinc zinc NN cord-344988-09vpehvf 204 4 deficiency deficiency NN cord-344988-09vpehvf 204 5 might may MD cord-344988-09vpehvf 204 6 contribute contribute VB cord-344988-09vpehvf 204 7 to to IN cord-344988-09vpehvf 204 8 diabetic diabetic JJ cord-344988-09vpehvf 204 9 complications complication NNS cord-344988-09vpehvf 204 10 [ [ -LRB- cord-344988-09vpehvf 204 11 21 21 CD cord-344988-09vpehvf 204 12 ] ] -RRB- cord-344988-09vpehvf 204 13 . . . cord-344988-09vpehvf 205 1 On on IN cord-344988-09vpehvf 205 2 the the DT cord-344988-09vpehvf 205 3 one one CD cord-344988-09vpehvf 205 4 hand hand NN cord-344988-09vpehvf 205 5 , , , cord-344988-09vpehvf 205 6 zinc zinc NN cord-344988-09vpehvf 205 7 is be VBZ cord-344988-09vpehvf 205 8 necessary necessary JJ cord-344988-09vpehvf 205 9 for for IN cord-344988-09vpehvf 205 10 insulin insulin NN cord-344988-09vpehvf 205 11 maturation maturation NN cord-344988-09vpehvf 205 12 and and CC cord-344988-09vpehvf 205 13 storage storage NN cord-344988-09vpehvf 205 14 as as IN cord-344988-09vpehvf 205 15 a a DT cord-344988-09vpehvf 205 16 solid solid JJ cord-344988-09vpehvf 205 17 hexamer hexamer NN cord-344988-09vpehvf 205 18 bound bind VBN cord-344988-09vpehvf 205 19 with with IN cord-344988-09vpehvf 205 20 two two CD cord-344988-09vpehvf 205 21 zinc zinc NN cord-344988-09vpehvf 205 22 ions ion NNS cord-344988-09vpehvf 205 23 per per IN cord-344988-09vpehvf 205 24 hexamer hexamer NN cord-344988-09vpehvf 205 25 in in IN cord-344988-09vpehvf 205 26 insulin insulin NN cord-344988-09vpehvf 205 27 secreting secrete VBG cord-344988-09vpehvf 205 28 pancreatic pancreatic NN cord-344988-09vpehvf 205 29 β β NN cord-344988-09vpehvf 205 30 cells cell NNS cord-344988-09vpehvf 205 31 [ [ -LRB- cord-344988-09vpehvf 205 32 30 30 CD cord-344988-09vpehvf 205 33 , , , cord-344988-09vpehvf 205 34 37 37 CD cord-344988-09vpehvf 205 35 , , , cord-344988-09vpehvf 205 36 53 53 CD cord-344988-09vpehvf 205 37 ] ] -RRB- cord-344988-09vpehvf 205 38 . . . cord-344988-09vpehvf 206 1 On on IN cord-344988-09vpehvf 206 2 the the DT cord-344988-09vpehvf 206 3 other other JJ cord-344988-09vpehvf 206 4 hand hand NN cord-344988-09vpehvf 206 5 , , , cord-344988-09vpehvf 206 6 zinc zinc NN cord-344988-09vpehvf 206 7 deficiency deficiency NN cord-344988-09vpehvf 206 8 comprises comprise VBZ cord-344988-09vpehvf 206 9 the the DT cord-344988-09vpehvf 206 10 potential potential NN cord-344988-09vpehvf 206 11 to to TO cord-344988-09vpehvf 206 12 hinder hinder VB cord-344988-09vpehvf 206 13 immune immune JJ cord-344988-09vpehvf 206 14 function function NN cord-344988-09vpehvf 206 15 , , , cord-344988-09vpehvf 206 16 interacting interact VBG cord-344988-09vpehvf 206 17 with with IN cord-344988-09vpehvf 206 18 pro pro JJ cord-344988-09vpehvf 206 19 - - JJ cord-344988-09vpehvf 206 20 inflammatory inflammatory JJ cord-344988-09vpehvf 206 21 cytokine cytokine NN cord-344988-09vpehvf 206 22 production production NN cord-344988-09vpehvf 206 23 as as IN cord-344988-09vpehvf 206 24 discussed discuss VBN cord-344988-09vpehvf 206 25 above above RB cord-344988-09vpehvf 206 26 . . . cord-344988-09vpehvf 207 1 Both both DT cord-344988-09vpehvf 207 2 effects effect NNS cord-344988-09vpehvf 207 3 suggest suggest VBP cord-344988-09vpehvf 207 4 a a DT cord-344988-09vpehvf 207 5 potential potential JJ cord-344988-09vpehvf 207 6 benefit benefit NN cord-344988-09vpehvf 207 7 for for IN cord-344988-09vpehvf 207 8 zinc zinc NN cord-344988-09vpehvf 207 9 as as IN cord-344988-09vpehvf 207 10 a a DT cord-344988-09vpehvf 207 11 supporting support VBG cord-344988-09vpehvf 207 12 therapeutic therapeutic JJ cord-344988-09vpehvf 207 13 intervention intervention NN cord-344988-09vpehvf 207 14 in in IN cord-344988-09vpehvf 207 15 diabetic diabetic JJ cord-344988-09vpehvf 207 16 patients patient NNS cord-344988-09vpehvf 207 17 . . . cord-344988-09vpehvf 208 1 Besides besides IN cord-344988-09vpehvf 208 2 its -PRON- PRP$ cord-344988-09vpehvf 208 3 action action NN cord-344988-09vpehvf 208 4 on on IN cord-344988-09vpehvf 208 5 the the DT cord-344988-09vpehvf 208 6 immune immune JJ cord-344988-09vpehvf 208 7 system system NN cord-344988-09vpehvf 208 8 , , , cord-344988-09vpehvf 208 9 zinc zinc NN cord-344988-09vpehvf 208 10 supplementation supplementation NN cord-344988-09vpehvf 208 11 may may MD cord-344988-09vpehvf 208 12 have have VB cord-344988-09vpehvf 208 13 an an DT cord-344988-09vpehvf 208 14 additional additional JJ cord-344988-09vpehvf 208 15 effect effect NN cord-344988-09vpehvf 208 16 on on IN cord-344988-09vpehvf 208 17 patients patient NNS cord-344988-09vpehvf 208 18 with with IN cord-344988-09vpehvf 208 19 IDDM IDDM NNP cord-344988-09vpehvf 208 20 or or CC cord-344988-09vpehvf 208 21 RA RA NNP cord-344988-09vpehvf 208 22 . . . cord-344988-09vpehvf 209 1 Zinc zinc NN cord-344988-09vpehvf 209 2 deficiency deficiency NN cord-344988-09vpehvf 209 3 is be VBZ cord-344988-09vpehvf 209 4 known know VBN cord-344988-09vpehvf 209 5 to to TO cord-344988-09vpehvf 209 6 induce induce VB cord-344988-09vpehvf 209 7 oxidative oxidative JJ cord-344988-09vpehvf 209 8 stress stress NN cord-344988-09vpehvf 209 9 [ [ -LRB- cord-344988-09vpehvf 209 10 18 18 CD cord-344988-09vpehvf 209 11 ] ] -RRB- cord-344988-09vpehvf 209 12 , , , cord-344988-09vpehvf 209 13 and and CC cord-344988-09vpehvf 209 14 in in IN cord-344988-09vpehvf 209 15 both both DT cord-344988-09vpehvf 209 16 diseases disease NNS cord-344988-09vpehvf 209 17 , , , cord-344988-09vpehvf 209 18 reactive reactive JJ cord-344988-09vpehvf 209 19 oxygen oxygen NN cord-344988-09vpehvf 209 20 species specie NNS cord-344988-09vpehvf 209 21 contribute contribute VBP cord-344988-09vpehvf 209 22 to to IN cord-344988-09vpehvf 209 23 the the DT cord-344988-09vpehvf 209 24 pathogenesis pathogenesis NN cord-344988-09vpehvf 209 25 [ [ -LRB- cord-344988-09vpehvf 209 26 1 1 CD cord-344988-09vpehvf 209 27 , , , cord-344988-09vpehvf 209 28 104 104 CD cord-344988-09vpehvf 209 29 ] ] -RRB- cord-344988-09vpehvf 209 30 . . . cord-344988-09vpehvf 210 1 The the DT cord-344988-09vpehvf 210 2 influence influence NN cord-344988-09vpehvf 210 3 of of IN cord-344988-09vpehvf 210 4 zinc zinc NN cord-344988-09vpehvf 210 5 on on IN cord-344988-09vpehvf 210 6 redox redox JJ cord-344988-09vpehvf 210 7 metabolism metabolism NN cord-344988-09vpehvf 210 8 is be VBZ cord-344988-09vpehvf 210 9 well well RB cord-344988-09vpehvf 210 10 established establish VBN cord-344988-09vpehvf 210 11 [ [ -LRB- cord-344988-09vpehvf 210 12 87 87 CD cord-344988-09vpehvf 210 13 , , , cord-344988-09vpehvf 210 14 115 115 CD cord-344988-09vpehvf 210 15 ] ] -RRB- cord-344988-09vpehvf 210 16 and and CC cord-344988-09vpehvf 210 17 several several JJ cord-344988-09vpehvf 210 18 mechanisms mechanism NNS cord-344988-09vpehvf 210 19 have have VBP cord-344988-09vpehvf 210 20 been be VBN cord-344988-09vpehvf 210 21 suggested suggest VBN cord-344988-09vpehvf 210 22 by by IN cord-344988-09vpehvf 210 23 which which WDT cord-344988-09vpehvf 210 24 zinc zinc NN cord-344988-09vpehvf 210 25 can can MD cord-344988-09vpehvf 210 26 act act VB cord-344988-09vpehvf 210 27 as as IN cord-344988-09vpehvf 210 28 an an DT cord-344988-09vpehvf 210 29 antioxidant antioxidant NN cord-344988-09vpehvf 210 30 . . . cord-344988-09vpehvf 211 1 Because because IN cord-344988-09vpehvf 211 2 zinc zinc NN cord-344988-09vpehvf 211 3 itself -PRON- PRP cord-344988-09vpehvf 211 4 is be VBZ cord-344988-09vpehvf 211 5 not not RB cord-344988-09vpehvf 211 6 redox redox JJ cord-344988-09vpehvf 211 7 active active JJ cord-344988-09vpehvf 211 8 in in IN cord-344988-09vpehvf 211 9 biological biological JJ cord-344988-09vpehvf 211 10 systems system NNS cord-344988-09vpehvf 211 11 , , , cord-344988-09vpehvf 211 12 its -PRON- PRP$ cord-344988-09vpehvf 211 13 antioxidant antioxidant JJ cord-344988-09vpehvf 211 14 function function NN cord-344988-09vpehvf 211 15 is be VBZ cord-344988-09vpehvf 211 16 indirect indirect JJ cord-344988-09vpehvf 211 17 , , , cord-344988-09vpehvf 211 18 for for IN cord-344988-09vpehvf 211 19 example example NN cord-344988-09vpehvf 211 20 through through IN cord-344988-09vpehvf 211 21 the the DT cord-344988-09vpehvf 211 22 expression expression NN cord-344988-09vpehvf 211 23 of of IN cord-344988-09vpehvf 211 24 MT MT NNP cord-344988-09vpehvf 211 25 [ [ -LRB- cord-344988-09vpehvf 211 26 59 59 CD cord-344988-09vpehvf 211 27 , , , cord-344988-09vpehvf 211 28 87 87 CD cord-344988-09vpehvf 211 29 ] ] -RRB- cord-344988-09vpehvf 211 30 . . . cord-344988-09vpehvf 212 1 Moreover moreover RB cord-344988-09vpehvf 212 2 , , , cord-344988-09vpehvf 212 3 zinc zinc NN cord-344988-09vpehvf 212 4 can can MD cord-344988-09vpehvf 212 5 bind bind VB cord-344988-09vpehvf 212 6 to to IN cord-344988-09vpehvf 212 7 thiolate thiolate JJ cord-344988-09vpehvf 212 8 groups group NNS cord-344988-09vpehvf 212 9 and and CC cord-344988-09vpehvf 212 10 protect protect VB cord-344988-09vpehvf 212 11 them -PRON- PRP cord-344988-09vpehvf 212 12 from from IN cord-344988-09vpehvf 212 13 oxidation oxidation NN cord-344988-09vpehvf 212 14 by by IN cord-344988-09vpehvf 212 15 lowering lower VBG cord-344988-09vpehvf 212 16 their -PRON- PRP$ cord-344988-09vpehvf 212 17 susceptibility susceptibility NN cord-344988-09vpehvf 212 18 to to IN cord-344988-09vpehvf 212 19 oxidation oxidation NN cord-344988-09vpehvf 212 20 [ [ -LRB- cord-344988-09vpehvf 212 21 87 87 CD cord-344988-09vpehvf 212 22 ] ] -RRB- cord-344988-09vpehvf 212 23 . . . cord-344988-09vpehvf 213 1 Other other JJ cord-344988-09vpehvf 213 2 trace trace NN cord-344988-09vpehvf 213 3 metals metal NNS cord-344988-09vpehvf 213 4 can can MD cord-344988-09vpehvf 213 5 also also RB cord-344988-09vpehvf 213 6 play play VB cord-344988-09vpehvf 213 7 a a DT cord-344988-09vpehvf 213 8 role role NN cord-344988-09vpehvf 213 9 in in IN cord-344988-09vpehvf 213 10 RA RA NNP cord-344988-09vpehvf 213 11 . . . cord-344988-09vpehvf 214 1 Excess excess JJ cord-344988-09vpehvf 214 2 iron iron NN cord-344988-09vpehvf 214 3 aggravates aggravate VBZ cord-344988-09vpehvf 214 4 inflamma inflamma NNP cord-344988-09vpehvf 214 5 - - HYPH cord-344988-09vpehvf 214 6 tion tion NN cord-344988-09vpehvf 214 7 [ [ -LRB- cord-344988-09vpehvf 214 8 1 1 CD cord-344988-09vpehvf 214 9 ] ] -RRB- cord-344988-09vpehvf 214 10 and and CC cord-344988-09vpehvf 214 11 zinc zinc NN cord-344988-09vpehvf 214 12 has have VBZ cord-344988-09vpehvf 214 13 been be VBN cord-344988-09vpehvf 214 14 shown show VBN cord-344988-09vpehvf 214 15 to to TO cord-344988-09vpehvf 214 16 counteract counteract VB cord-344988-09vpehvf 214 17 transition transition NN cord-344988-09vpehvf 214 18 metal metal NN cord-344988-09vpehvf 214 19 - - HYPH cord-344988-09vpehvf 214 20 mediated mediate VBN cord-344988-09vpehvf 214 21 oxidation oxidation NN cord-344988-09vpehvf 214 22 by by IN cord-344988-09vpehvf 214 23 interfering interfere VBG cord-344988-09vpehvf 214 24 with with IN cord-344988-09vpehvf 214 25 the the DT cord-344988-09vpehvf 214 26 Haber Haber NNP cord-344988-09vpehvf 214 27 Weiss Weiss NNP cord-344988-09vpehvf 214 28 cycle cycle NN cord-344988-09vpehvf 214 29 [ [ -LRB- cord-344988-09vpehvf 214 30 18 18 CD cord-344988-09vpehvf 214 31 ] ] -RRB- cord-344988-09vpehvf 214 32 . . . cord-344988-09vpehvf 215 1 Finally finally RB cord-344988-09vpehvf 215 2 , , , cord-344988-09vpehvf 215 3 zinc zinc NN cord-344988-09vpehvf 215 4 is be VBZ cord-344988-09vpehvf 215 5 important important JJ cord-344988-09vpehvf 215 6 for for IN cord-344988-09vpehvf 215 7 antioxidant antioxidant JJ cord-344988-09vpehvf 215 8 enzymes enzyme NNS cord-344988-09vpehvf 215 9 . . . cord-344988-09vpehvf 216 1 It -PRON- PRP cord-344988-09vpehvf 216 2 was be VBD cord-344988-09vpehvf 216 3 suggested suggest VBN cord-344988-09vpehvf 216 4 that that IN cord-344988-09vpehvf 216 5 zinc zinc NN cord-344988-09vpehvf 216 6 may may MD cord-344988-09vpehvf 216 7 exert exert VB cord-344988-09vpehvf 216 8 an an DT cord-344988-09vpehvf 216 9 effect effect NN cord-344988-09vpehvf 216 10 on on IN cord-344988-09vpehvf 216 11 lipid lipid NN cord-344988-09vpehvf 216 12 peroxidation peroxidation NN cord-344988-09vpehvf 216 13 by by IN cord-344988-09vpehvf 216 14 protecting protect VBG cord-344988-09vpehvf 216 15 the the DT cord-344988-09vpehvf 216 16 active active JJ cord-344988-09vpehvf 216 17 site site NN cord-344988-09vpehvf 216 18 of of IN cord-344988-09vpehvf 216 19 the the DT cord-344988-09vpehvf 216 20 selenium selenium NN cord-344988-09vpehvf 216 21 - - HYPH cord-344988-09vpehvf 216 22 glutathione glutathione NN cord-344988-09vpehvf 216 23 peroxidase peroxidase NN cord-344988-09vpehvf 216 24 , , , cord-344988-09vpehvf 216 25 which which WDT cord-344988-09vpehvf 216 26 is be VBZ cord-344988-09vpehvf 216 27 important important JJ cord-344988-09vpehvf 216 28 for for IN cord-344988-09vpehvf 216 29 detoxification detoxification NN cord-344988-09vpehvf 216 30 of of IN cord-344988-09vpehvf 216 31 reactive reactive JJ cord-344988-09vpehvf 216 32 oxygen oxygen NN cord-344988-09vpehvf 216 33 species specie NNS cord-344988-09vpehvf 216 34 , , , cord-344988-09vpehvf 216 35 against against IN cord-344988-09vpehvf 216 36 the the DT cord-344988-09vpehvf 216 37 binding binding NN cord-344988-09vpehvf 216 38 of of IN cord-344988-09vpehvf 216 39 toxic toxic JJ cord-344988-09vpehvf 216 40 ligands ligand NNS cord-344988-09vpehvf 216 41 with with IN cord-344988-09vpehvf 216 42 subsequent subsequent JJ cord-344988-09vpehvf 216 43 inactivation inactivation NN cord-344988-09vpehvf 216 44 of of IN cord-344988-09vpehvf 216 45 the the DT cord-344988-09vpehvf 216 46 enzyme enzyme NN cord-344988-09vpehvf 216 47 [ [ -LRB- cord-344988-09vpehvf 216 48 39 39 CD cord-344988-09vpehvf 216 49 ] ] -RRB- cord-344988-09vpehvf 216 50 . . . cord-344988-09vpehvf 217 1 In in IN cord-344988-09vpehvf 217 2 addition addition NN cord-344988-09vpehvf 217 3 , , , cord-344988-09vpehvf 217 4 the the DT cord-344988-09vpehvf 217 5 zinccontaining zinccontaine VBG cord-344988-09vpehvf 217 6 metalloenzyme metalloenzyme NNP cord-344988-09vpehvf 217 7 Cu Cu NNP cord-344988-09vpehvf 217 8 / / SYM cord-344988-09vpehvf 217 9 Zn Zn NNP cord-344988-09vpehvf 217 10 superoxide superoxide NN cord-344988-09vpehvf 217 11 dismutase dismutase NN cord-344988-09vpehvf 217 12 , , , cord-344988-09vpehvf 217 13 which which WDT cord-344988-09vpehvf 217 14 catalyzes catalyze VBZ cord-344988-09vpehvf 217 15 the the DT cord-344988-09vpehvf 217 16 degradation degradation NN cord-344988-09vpehvf 217 17 of of IN cord-344988-09vpehvf 217 18 superoxide superoxide NN cord-344988-09vpehvf 217 19 to to IN cord-344988-09vpehvf 217 20 hydrogen hydrogen NN cord-344988-09vpehvf 217 21 peroxide peroxide NN cord-344988-09vpehvf 217 22 , , , cord-344988-09vpehvf 217 23 is be VBZ cord-344988-09vpehvf 217 24 effective effective JJ cord-344988-09vpehvf 217 25 against against IN cord-344988-09vpehvf 217 26 IDDM IDDM NNP cord-344988-09vpehvf 217 27 [ [ -LRB- cord-344988-09vpehvf 217 28 76 76 CD cord-344988-09vpehvf 217 29 ] ] -RRB- cord-344988-09vpehvf 217 30 and and CC cord-344988-09vpehvf 217 31 RA RA NNP cord-344988-09vpehvf 217 32 [ [ -LRB- cord-344988-09vpehvf 217 33 1 1 CD cord-344988-09vpehvf 217 34 ] ] -RRB- cord-344988-09vpehvf 217 35 in in IN cord-344988-09vpehvf 217 36 vivo vivo NN cord-344988-09vpehvf 217 37 . . . cord-344988-09vpehvf 218 1 How how WRB cord-344988-09vpehvf 218 2 much much JJ cord-344988-09vpehvf 218 3 does do VBZ cord-344988-09vpehvf 218 4 the the DT cord-344988-09vpehvf 218 5 zinc zinc NN cord-344988-09vpehvf 218 6 deficiency deficiency NN cord-344988-09vpehvf 218 7 observed observe VBN cord-344988-09vpehvf 218 8 in in IN cord-344988-09vpehvf 218 9 both both DT cord-344988-09vpehvf 218 10 types type NNS cord-344988-09vpehvf 218 11 of of IN cord-344988-09vpehvf 218 12 patients patient NNS cord-344988-09vpehvf 218 13 contribute contribute VBP cord-344988-09vpehvf 218 14 to to IN cord-344988-09vpehvf 218 15 oxidative oxidative JJ cord-344988-09vpehvf 218 16 damage damage NN cord-344988-09vpehvf 218 17 ? ? . cord-344988-09vpehvf 219 1 Although although IN cord-344988-09vpehvf 219 2 this this DT cord-344988-09vpehvf 219 3 has have VBZ cord-344988-09vpehvf 219 4 not not RB cord-344988-09vpehvf 219 5 been be VBN cord-344988-09vpehvf 219 6 directly directly RB cord-344988-09vpehvf 219 7 investigated investigate VBN cord-344988-09vpehvf 219 8 so so RB cord-344988-09vpehvf 219 9 far far RB cord-344988-09vpehvf 219 10 , , , cord-344988-09vpehvf 219 11 the the DT cord-344988-09vpehvf 219 12 improvement improvement NN cord-344988-09vpehvf 219 13 in in IN cord-344988-09vpehvf 219 14 parameters parameter NNS cord-344988-09vpehvf 219 15 for for IN cord-344988-09vpehvf 219 16 oxidative oxidative JJ cord-344988-09vpehvf 219 17 stress stress NN cord-344988-09vpehvf 219 18 in in IN cord-344988-09vpehvf 219 19 diabetic diabetic JJ cord-344988-09vpehvf 219 20 patients patient NNS cord-344988-09vpehvf 219 21 indicates indicate VBZ cord-344988-09vpehvf 219 22 that that IN cord-344988-09vpehvf 219 23 the the DT cord-344988-09vpehvf 219 24 antioxidant antioxidant JJ cord-344988-09vpehvf 219 25 effect effect NN cord-344988-09vpehvf 219 26 of of IN cord-344988-09vpehvf 219 27 zinc zinc NN cord-344988-09vpehvf 219 28 is be VBZ cord-344988-09vpehvf 219 29 relevant relevant JJ cord-344988-09vpehvf 219 30 for for IN cord-344988-09vpehvf 219 31 disease disease NN cord-344988-09vpehvf 219 32 progression progression NN cord-344988-09vpehvf 219 33 in in IN cord-344988-09vpehvf 219 34 vivo vivo NN cord-344988-09vpehvf 219 35 . . . cord-344988-09vpehvf 220 1 One one CD cord-344988-09vpehvf 220 2 study study NN cord-344988-09vpehvf 220 3 found find VBD cord-344988-09vpehvf 220 4 a a DT cord-344988-09vpehvf 220 5 positive positive JJ cord-344988-09vpehvf 220 6 effect effect NN cord-344988-09vpehvf 220 7 on on IN cord-344988-09vpehvf 220 8 oxidative oxidative JJ cord-344988-09vpehvf 220 9 stress stress NN cord-344988-09vpehvf 220 10 , , , cord-344988-09vpehvf 220 11 measured measure VBN cord-344988-09vpehvf 220 12 by by IN cord-344988-09vpehvf 220 13 an an DT cord-344988-09vpehvf 220 14 increase increase NN cord-344988-09vpehvf 220 15 in in IN cord-344988-09vpehvf 220 16 selenium selenium NN cord-344988-09vpehvf 220 17 - - HYPH cord-344988-09vpehvf 220 18 glutathione glutathione NN cord-344988-09vpehvf 220 19 peroxidase peroxidase NN cord-344988-09vpehvf 220 20 activity activity NN cord-344988-09vpehvf 220 21 , , , cord-344988-09vpehvf 220 22 and and CC cord-344988-09vpehvf 220 23 a a DT cord-344988-09vpehvf 220 24 decrease decrease NN cord-344988-09vpehvf 220 25 in in IN cord-344988-09vpehvf 220 26 plasma plasma NN cord-344988-09vpehvf 220 27 thiobarbituric thiobarbituric JJ cord-344988-09vpehvf 220 28 acid acid NN cord-344988-09vpehvf 220 29 reactive reactive JJ cord-344988-09vpehvf 220 30 substances substance NNS cord-344988-09vpehvf 220 31 , , , cord-344988-09vpehvf 220 32 which which WDT cord-344988-09vpehvf 220 33 are be VBP cord-344988-09vpehvf 220 34 an an DT cord-344988-09vpehvf 220 35 indicator indicator NN cord-344988-09vpehvf 220 36 for for IN cord-344988-09vpehvf 220 37 lipid lipid NN cord-344988-09vpehvf 220 38 peroxidation peroxidation NN cord-344988-09vpehvf 220 39 [ [ -LRB- cord-344988-09vpehvf 220 40 39 39 CD cord-344988-09vpehvf 220 41 ] ] -RRB- cord-344988-09vpehvf 220 42 . . . cord-344988-09vpehvf 221 1 On on IN cord-344988-09vpehvf 221 2 the the DT cord-344988-09vpehvf 221 3 other other JJ cord-344988-09vpehvf 221 4 hand hand NN cord-344988-09vpehvf 221 5 , , , cord-344988-09vpehvf 221 6 two two CD cord-344988-09vpehvf 221 7 other other JJ cord-344988-09vpehvf 221 8 studies study NNS cord-344988-09vpehvf 221 9 detected detect VBD cord-344988-09vpehvf 221 10 an an DT cord-344988-09vpehvf 221 11 increase increase NN cord-344988-09vpehvf 221 12 in in IN cord-344988-09vpehvf 221 13 the the DT cord-344988-09vpehvf 221 14 glycosylated glycosylated JJ cord-344988-09vpehvf 221 15 form form NN cord-344988-09vpehvf 221 16 of of IN cord-344988-09vpehvf 221 17 hemoglobin hemoglobin NN cord-344988-09vpehvf 221 18 , , , cord-344988-09vpehvf 221 19 HbA1c HbA1c NNP cord-344988-09vpehvf 221 20 , , , cord-344988-09vpehvf 221 21 indicating indicate VBG cord-344988-09vpehvf 221 22 a a DT cord-344988-09vpehvf 221 23 further further JJ cord-344988-09vpehvf 221 24 deterioration deterioration NN cord-344988-09vpehvf 221 25 of of IN cord-344988-09vpehvf 221 26 metabolic metabolic JJ cord-344988-09vpehvf 221 27 control control NN cord-344988-09vpehvf 221 28 [ [ -LRB- cord-344988-09vpehvf 221 29 25 25 CD cord-344988-09vpehvf 221 30 , , , cord-344988-09vpehvf 221 31 29 29 CD cord-344988-09vpehvf 221 32 ] ] -RRB- cord-344988-09vpehvf 221 33 . . . cord-344988-09vpehvf 222 1 Taken take VBN cord-344988-09vpehvf 222 2 together together RB cord-344988-09vpehvf 222 3 , , , cord-344988-09vpehvf 222 4 it -PRON- PRP cord-344988-09vpehvf 222 5 seems seem VBZ cord-344988-09vpehvf 222 6 that that IN cord-344988-09vpehvf 222 7 zinc zinc NN cord-344988-09vpehvf 222 8 supplementation supplementation NN cord-344988-09vpehvf 222 9 can can MD cord-344988-09vpehvf 222 10 be be VB cord-344988-09vpehvf 222 11 helpful helpful JJ cord-344988-09vpehvf 222 12 against against IN cord-344988-09vpehvf 222 13 oxidative oxidative JJ cord-344988-09vpehvf 222 14 stress stress NN cord-344988-09vpehvf 222 15 , , , cord-344988-09vpehvf 222 16 but but CC cord-344988-09vpehvf 222 17 its -PRON- PRP$ cord-344988-09vpehvf 222 18 effect effect NN cord-344988-09vpehvf 222 19 on on IN cord-344988-09vpehvf 222 20 glucose glucose NN cord-344988-09vpehvf 222 21 metabolism metabolism NN cord-344988-09vpehvf 222 22 may may MD cord-344988-09vpehvf 222 23 limit limit VB cord-344988-09vpehvf 222 24 its -PRON- PRP$ cord-344988-09vpehvf 222 25 usefulness usefulness NN cord-344988-09vpehvf 222 26 in in IN cord-344988-09vpehvf 222 27 diabetic diabetic JJ cord-344988-09vpehvf 222 28 patients patient NNS cord-344988-09vpehvf 222 29 . . . cord-344988-09vpehvf 222 30 _SP cord-344988-09vpehvf 223 1 Antibody antibody NN cord-344988-09vpehvf 223 2 production production NN cord-344988-09vpehvf 223 3 during during IN cord-344988-09vpehvf 223 4 both both CC cord-344988-09vpehvf 223 5 the the DT cord-344988-09vpehvf 223 6 first first JJ cord-344988-09vpehvf 223 7 and and CC cord-344988-09vpehvf 223 8 an an DT cord-344988-09vpehvf 223 9 immunological immunological JJ cord-344988-09vpehvf 223 10 memory memory NN cord-344988-09vpehvf 223 11 response response NN cord-344988-09vpehvf 223 12 is be VBZ cord-344988-09vpehvf 223 13 disturbed disturb VBN cord-344988-09vpehvf 223 14 by by IN cord-344988-09vpehvf 223 15 zinc zinc NN cord-344988-09vpehvf 223 16 deficiency deficiency NN cord-344988-09vpehvf 223 17 [ [ -LRB- cord-344988-09vpehvf 223 18 28 28 CD cord-344988-09vpehvf 223 19 , , , cord-344988-09vpehvf 223 20 44 44 CD cord-344988-09vpehvf 223 21 , , , cord-344988-09vpehvf 223 22 45 45 CD cord-344988-09vpehvf 223 23 ] ] -RRB- cord-344988-09vpehvf 223 24 , , , cord-344988-09vpehvf 223 25 suggesting suggest VBG cord-344988-09vpehvf 223 26 that that IN cord-344988-09vpehvf 223 27 zinc zinc NN cord-344988-09vpehvf 223 28 supplementation supplementation NN cord-344988-09vpehvf 223 29 could could MD cord-344988-09vpehvf 223 30 improve improve VB cord-344988-09vpehvf 223 31 vaccination vaccination NN cord-344988-09vpehvf 223 32 results result NNS cord-344988-09vpehvf 223 33 . . . cord-344988-09vpehvf 224 1 Experiments experiment NNS cord-344988-09vpehvf 224 2 in in IN cord-344988-09vpehvf 224 3 mice mouse NNS cord-344988-09vpehvf 224 4 showed show VBD cord-344988-09vpehvf 224 5 that that IN cord-344988-09vpehvf 224 6 antibody antibody NN cord-344988-09vpehvf 224 7 production production NN cord-344988-09vpehvf 224 8 in in IN cord-344988-09vpehvf 224 9 response response NN cord-344988-09vpehvf 224 10 to to IN cord-344988-09vpehvf 224 11 T T NNP cord-344988-09vpehvf 224 12 cell cell NN cord-344988-09vpehvf 224 13 - - HYPH cord-344988-09vpehvf 224 14 dependent dependent JJ cord-344988-09vpehvf 224 15 antigens antigen NNS cord-344988-09vpehvf 224 16 is be VBZ cord-344988-09vpehvf 224 17 more more RBR cord-344988-09vpehvf 224 18 sensitive sensitive JJ cord-344988-09vpehvf 224 19 to to IN cord-344988-09vpehvf 224 20 zinc zinc NN cord-344988-09vpehvf 224 21 deficiency deficiency NN cord-344988-09vpehvf 224 22 than than IN cord-344988-09vpehvf 224 23 in in IN cord-344988-09vpehvf 224 24 response response NN cord-344988-09vpehvf 224 25 to to IN cord-344988-09vpehvf 224 26 T T NNP cord-344988-09vpehvf 224 27 cell cell NN cord-344988-09vpehvf 224 28 - - HYPH cord-344988-09vpehvf 224 29 independent independent JJ cord-344988-09vpehvf 224 30 antigens antigen NNS cord-344988-09vpehvf 224 31 [ [ -LRB- cord-344988-09vpehvf 224 32 96 96 CD cord-344988-09vpehvf 224 33 ] ] -RRB- cord-344988-09vpehvf 224 34 and and CC cord-344988-09vpehvf 225 1 zinc zinc NN cord-344988-09vpehvf 225 2 deficiency deficiency NN cord-344988-09vpehvf 225 3 impairs impair VBZ cord-344988-09vpehvf 225 4 TH TH NNP cord-344988-09vpehvf 225 5 cell cell NN cord-344988-09vpehvf 225 6 function function NN cord-344988-09vpehvf 225 7 [ [ -LRB- cord-344988-09vpehvf 225 8 43 43 CD cord-344988-09vpehvf 225 9 ] ] -RRB- cord-344988-09vpehvf 225 10 . . . cord-344988-09vpehvf 226 1 The the DT cord-344988-09vpehvf 226 2 various various JJ cord-344988-09vpehvf 226 3 effects effect NNS cord-344988-09vpehvf 226 4 of of IN cord-344988-09vpehvf 226 5 zinc zinc NN cord-344988-09vpehvf 226 6 supplementation supplementation NN cord-344988-09vpehvf 226 7 on on IN cord-344988-09vpehvf 226 8 different different JJ cord-344988-09vpehvf 226 9 forms form NNS cord-344988-09vpehvf 226 10 of of IN cord-344988-09vpehvf 226 11 vaccination vaccination NN cord-344988-09vpehvf 226 12 are be VBP cord-344988-09vpehvf 226 13 listed list VBN cord-344988-09vpehvf 226 14 in in IN cord-344988-09vpehvf 226 15 Table Table NNP cord-344988-09vpehvf 226 16 7 7 CD cord-344988-09vpehvf 226 17 . . . cord-344988-09vpehvf 227 1 Although although IN cord-344988-09vpehvf 227 2 both both DT cord-344988-09vpehvf 227 3 the the DT cord-344988-09vpehvf 227 4 elderly elderly JJ cord-344988-09vpehvf 227 5 and and CC cord-344988-09vpehvf 227 6 hemodialysis hemodialysis NN cord-344988-09vpehvf 227 7 patients patient NNS cord-344988-09vpehvf 227 8 have have VBP cord-344988-09vpehvf 227 9 a a DT cord-344988-09vpehvf 227 10 high high JJ cord-344988-09vpehvf 227 11 risk risk NN cord-344988-09vpehvf 227 12 for for IN cord-344988-09vpehvf 227 13 being be VBG cord-344988-09vpehvf 227 14 zinc zinc NN cord-344988-09vpehvf 227 15 deficient deficient JJ cord-344988-09vpehvf 227 16 , , , cord-344988-09vpehvf 227 17 there there EX cord-344988-09vpehvf 227 18 was be VBD cord-344988-09vpehvf 227 19 no no DT cord-344988-09vpehvf 227 20 influence influence NN cord-344988-09vpehvf 227 21 of of IN cord-344988-09vpehvf 227 22 zinc zinc NN cord-344988-09vpehvf 227 23 on on IN cord-344988-09vpehvf 227 24 influenza influenza NN cord-344988-09vpehvf 227 25 vaccination vaccination NN cord-344988-09vpehvf 227 26 in in IN cord-344988-09vpehvf 227 27 either either DT cord-344988-09vpehvf 227 28 group group NN cord-344988-09vpehvf 227 29 [ [ -LRB- cord-344988-09vpehvf 227 30 122 122 CD cord-344988-09vpehvf 227 31 , , , cord-344988-09vpehvf 227 32 127 127 CD cord-344988-09vpehvf 227 33 , , , cord-344988-09vpehvf 227 34 156 156 CD cord-344988-09vpehvf 227 35 ] ] -RRB- cord-344988-09vpehvf 227 36 . . . cord-344988-09vpehvf 228 1 Conversely conversely RB cord-344988-09vpehvf 228 2 , , , cord-344988-09vpehvf 228 3 there there EX cord-344988-09vpehvf 228 4 is be VBZ cord-344988-09vpehvf 228 5 one one CD cord-344988-09vpehvf 228 6 study study NN cord-344988-09vpehvf 228 7 from from IN cord-344988-09vpehvf 228 8 which which WDT cord-344988-09vpehvf 228 9 a a DT cord-344988-09vpehvf 228 10 relationship relationship NN cord-344988-09vpehvf 228 11 between between IN cord-344988-09vpehvf 228 12 zinc zinc NN cord-344988-09vpehvf 228 13 status status NN cord-344988-09vpehvf 228 14 and and CC cord-344988-09vpehvf 228 15 vaccination vaccination NN cord-344988-09vpehvf 228 16 response response NN cord-344988-09vpehvf 228 17 can can MD cord-344988-09vpehvf 228 18 be be VB cord-344988-09vpehvf 228 19 concluded conclude VBN cord-344988-09vpehvf 228 20 . . . cord-344988-09vpehvf 229 1 In in IN cord-344988-09vpehvf 229 2 this this DT cord-344988-09vpehvf 229 3 report report NN cord-344988-09vpehvf 229 4 , , , cord-344988-09vpehvf 229 5 a a DT cord-344988-09vpehvf 229 6 correlation correlation NN cord-344988-09vpehvf 229 7 between between IN cord-344988-09vpehvf 229 8 failure failure NN cord-344988-09vpehvf 229 9 to to TO cord-344988-09vpehvf 229 10 respond respond VB cord-344988-09vpehvf 229 11 to to IN cord-344988-09vpehvf 229 12 diphtheria diphtheria NN cord-344988-09vpehvf 229 13 vaccination vaccination NN cord-344988-09vpehvf 229 14 by by IN cord-344988-09vpehvf 229 15 elderly elderly JJ cord-344988-09vpehvf 229 16 chronic chronic JJ cord-344988-09vpehvf 229 17 hemodialysis hemodialysis NN cord-344988-09vpehvf 229 18 patients patient NNS cord-344988-09vpehvf 229 19 and and CC cord-344988-09vpehvf 229 20 low low JJ cord-344988-09vpehvf 229 21 serum serum NN cord-344988-09vpehvf 229 22 zinc zinc NN cord-344988-09vpehvf 229 23 level level NN cord-344988-09vpehvf 229 24 was be VBD cord-344988-09vpehvf 229 25 found find VBN cord-344988-09vpehvf 229 26 [ [ -LRB- cord-344988-09vpehvf 229 27 75 75 CD cord-344988-09vpehvf 229 28 ] ] -RRB- cord-344988-09vpehvf 229 29 . . . cord-344988-09vpehvf 230 1 Other other JJ cord-344988-09vpehvf 230 2 studies study NNS cord-344988-09vpehvf 230 3 analyzed analyze VBD cord-344988-09vpehvf 230 4 the the DT cord-344988-09vpehvf 230 5 effect effect NN cord-344988-09vpehvf 230 6 of of IN cord-344988-09vpehvf 230 7 zinc zinc NN cord-344988-09vpehvf 230 8 on on IN cord-344988-09vpehvf 230 9 cholera cholera NN cord-344988-09vpehvf 230 10 vaccination vaccination NN cord-344988-09vpehvf 230 11 and and CC cord-344988-09vpehvf 230 12 had have VBD cord-344988-09vpehvf 230 13 contradictory contradictory JJ cord-344988-09vpehvf 230 14 results result NNS cord-344988-09vpehvf 230 15 . . . cord-344988-09vpehvf 231 1 On on IN cord-344988-09vpehvf 231 2 the the DT cord-344988-09vpehvf 231 3 one one CD cord-344988-09vpehvf 231 4 hand hand NN cord-344988-09vpehvf 231 5 , , , cord-344988-09vpehvf 231 6 an an DT cord-344988-09vpehvf 231 7 increase increase NN cord-344988-09vpehvf 231 8 in in IN cord-344988-09vpehvf 231 9 vibriocidal vibriocidal JJ cord-344988-09vpehvf 231 10 antibody antibody NN cord-344988-09vpehvf 231 11 titers titer NNS cord-344988-09vpehvf 231 12 after after IN cord-344988-09vpehvf 231 13 zinc zinc NN cord-344988-09vpehvf 231 14 therapy therapy NN cord-344988-09vpehvf 231 15 could could MD cord-344988-09vpehvf 231 16 be be VB cord-344988-09vpehvf 231 17 found find VBN cord-344988-09vpehvf 231 18 [ [ -LRB- cord-344988-09vpehvf 231 19 4 4 CD cord-344988-09vpehvf 231 20 , , , cord-344988-09vpehvf 231 21 68 68 CD cord-344988-09vpehvf 231 22 ] ] -RRB- cord-344988-09vpehvf 231 23 , , , cord-344988-09vpehvf 231 24 while while IN cord-344988-09vpehvf 231 25 on on IN cord-344988-09vpehvf 231 26 the the DT cord-344988-09vpehvf 231 27 other other JJ cord-344988-09vpehvf 231 28 , , , cord-344988-09vpehvf 231 29 a a DT cord-344988-09vpehvf 231 30 suppression suppression NN cord-344988-09vpehvf 231 31 of of IN cord-344988-09vpehvf 231 32 antibody antibody NN cord-344988-09vpehvf 231 33 formation formation NN cord-344988-09vpehvf 231 34 against against IN cord-344988-09vpehvf 231 35 cholera cholera NN cord-344988-09vpehvf 231 36 toxin toxin NN cord-344988-09vpehvf 231 37 was be VBD cord-344988-09vpehvf 231 38 detected detect VBN cord-344988-09vpehvf 231 39 [ [ -LRB- cord-344988-09vpehvf 231 40 68 68 CD cord-344988-09vpehvf 231 41 , , , cord-344988-09vpehvf 231 42 123 123 CD cord-344988-09vpehvf 231 43 ] ] -RRB- cord-344988-09vpehvf 231 44 . . . cord-344988-09vpehvf 232 1 So so RB cord-344988-09vpehvf 232 2 far far RB cord-344988-09vpehvf 232 3 , , , cord-344988-09vpehvf 232 4 only only RB cord-344988-09vpehvf 232 5 one one CD cord-344988-09vpehvf 232 6 study study NN cord-344988-09vpehvf 232 7 has have VBZ cord-344988-09vpehvf 232 8 reported report VBN cord-344988-09vpehvf 232 9 an an DT cord-344988-09vpehvf 232 10 entirely entirely RB cord-344988-09vpehvf 232 11 beneficial beneficial JJ cord-344988-09vpehvf 232 12 effect effect NN cord-344988-09vpehvf 232 13 of of IN cord-344988-09vpehvf 232 14 zinc zinc NN cord-344988-09vpehvf 232 15 on on IN cord-344988-09vpehvf 232 16 vaccination vaccination NN cord-344988-09vpehvf 232 17 . . . cord-344988-09vpehvf 233 1 In in IN cord-344988-09vpehvf 233 2 contrast contrast NN cord-344988-09vpehvf 233 3 to to IN cord-344988-09vpehvf 233 4 all all DT cord-344988-09vpehvf 233 5 other other JJ cord-344988-09vpehvf 233 6 studies study NNS cord-344988-09vpehvf 233 7 , , , cord-344988-09vpehvf 233 8 the the DT cord-344988-09vpehvf 233 9 patients patient NNS cord-344988-09vpehvf 233 10 started start VBD cord-344988-09vpehvf 233 11 with with IN cord-344988-09vpehvf 233 12 zinc zinc NN cord-344988-09vpehvf 233 13 treatment treatment NN cord-344988-09vpehvf 233 14 one one CD cord-344988-09vpehvf 233 15 month month NN cord-344988-09vpehvf 233 16 prior prior RB cord-344988-09vpehvf 233 17 to to IN cord-344988-09vpehvf 233 18 tetanus tetanus JJ cord-344988-09vpehvf 233 19 vaccination vaccination NN cord-344988-09vpehvf 233 20 , , , cord-344988-09vpehvf 233 21 but but CC cord-344988-09vpehvf 233 22 stopped stop VBD cord-344988-09vpehvf 233 23 taking take VBG cord-344988-09vpehvf 233 24 zinc zinc NN cord-344988-09vpehvf 233 25 during during IN cord-344988-09vpehvf 233 26 vaccination vaccination NN cord-344988-09vpehvf 233 27 . . . cord-344988-09vpehvf 234 1 Following follow VBG cord-344988-09vpehvf 234 2 this this DT cord-344988-09vpehvf 234 3 treatment treatment NN cord-344988-09vpehvf 234 4 the the DT cord-344988-09vpehvf 234 5 patients patient NNS cord-344988-09vpehvf 234 6 showed show VBD cord-344988-09vpehvf 234 7 an an DT cord-344988-09vpehvf 234 8 increase increase NN cord-344988-09vpehvf 234 9 in in IN cord-344988-09vpehvf 234 10 the the DT cord-344988-09vpehvf 234 11 anti anti JJ cord-344988-09vpehvf 234 12 - - JJ cord-344988-09vpehvf 234 13 tetanus tetanus JJ cord-344988-09vpehvf 234 14 toxin toxin NN cord-344988-09vpehvf 234 15 IgG igg NN cord-344988-09vpehvf 234 16 titer titer NN cord-344988-09vpehvf 234 17 and and CC cord-344988-09vpehvf 234 18 also also RB cord-344988-09vpehvf 234 19 in in IN cord-344988-09vpehvf 234 20 the the DT cord-344988-09vpehvf 234 21 number number NN cord-344988-09vpehvf 234 22 of of IN cord-344988-09vpehvf 234 23 circulating circulate VBG cord-344988-09vpehvf 234 24 T T NNP cord-344988-09vpehvf 234 25 lymphocytes lymphocyte NNS cord-344988-09vpehvf 234 26 and and CC cord-344988-09vpehvf 234 27 an an DT cord-344988-09vpehvf 234 28 improved improved JJ cord-344988-09vpehvf 234 29 delayed delayed JJ cord-344988-09vpehvf 234 30 type type NN cord-344988-09vpehvf 234 31 hypersensitivity hypersensitivity NN cord-344988-09vpehvf 234 32 reaction reaction NN cord-344988-09vpehvf 234 33 toward toward IN cord-344988-09vpehvf 234 34 several several JJ cord-344988-09vpehvf 234 35 different different JJ cord-344988-09vpehvf 234 36 antigens antigen NNS cord-344988-09vpehvf 234 37 [ [ -LRB- cord-344988-09vpehvf 234 38 32 32 CD cord-344988-09vpehvf 234 39 ] ] -RRB- cord-344988-09vpehvf 234 40 . . . cord-344988-09vpehvf 235 1 Potentially potentially RB cord-344988-09vpehvf 235 2 , , , cord-344988-09vpehvf 235 3 zinc zinc NN cord-344988-09vpehvf 235 4 is be VBZ cord-344988-09vpehvf 235 5 required require VBN cord-344988-09vpehvf 235 6 to to TO cord-344988-09vpehvf 235 7 restore restore VB cord-344988-09vpehvf 235 8 normal normal JJ cord-344988-09vpehvf 235 9 TH TH NNP cord-344988-09vpehvf 235 10 cell cell NN cord-344988-09vpehvf 235 11 function function NN cord-344988-09vpehvf 235 12 , , , cord-344988-09vpehvf 235 13 but but CC cord-344988-09vpehvf 235 14 because because IN cord-344988-09vpehvf 235 15 it -PRON- PRP cord-344988-09vpehvf 235 16 has have VBZ cord-344988-09vpehvf 235 17 a a DT cord-344988-09vpehvf 235 18 direct direct JJ cord-344988-09vpehvf 235 19 inhibitory inhibitory JJ cord-344988-09vpehvf 235 20 effect effect NN cord-344988-09vpehvf 235 21 on on IN cord-344988-09vpehvf 235 22 T t NN cord-344988-09vpehvf 235 23 lymphocytes lymphocyte NNS cord-344988-09vpehvf 235 24 [ [ -LRB- cord-344988-09vpehvf 235 25 171 171 CD cord-344988-09vpehvf 235 26 ] ] -RRB- cord-344988-09vpehvf 235 27 , , , cord-344988-09vpehvf 235 28 supplementation supplementation NN cord-344988-09vpehvf 235 29 during during IN cord-344988-09vpehvf 235 30 vaccination vaccination NN cord-344988-09vpehvf 235 31 may may MD cord-344988-09vpehvf 235 32 hinder hinder VB cord-344988-09vpehvf 235 33 efficient efficient JJ cord-344988-09vpehvf 235 34 vaccination vaccination NN cord-344988-09vpehvf 235 35 response response NN cord-344988-09vpehvf 235 36 . . . cord-344988-09vpehvf 236 1 It -PRON- PRP cord-344988-09vpehvf 236 2 may may MD cord-344988-09vpehvf 236 3 be be VB cord-344988-09vpehvf 236 4 a a DT cord-344988-09vpehvf 236 5 promising promising JJ cord-344988-09vpehvf 236 6 approach approach NN cord-344988-09vpehvf 236 7 to to TO cord-344988-09vpehvf 236 8 investigate investigate VB cord-344988-09vpehvf 236 9 the the DT cord-344988-09vpehvf 236 10 time time NN cord-344988-09vpehvf 236 11 - - HYPH cord-344988-09vpehvf 236 12 and and CC cord-344988-09vpehvf 236 13 concentration concentration NN cord-344988-09vpehvf 236 14 - - HYPH cord-344988-09vpehvf 236 15 dependent dependent JJ cord-344988-09vpehvf 236 16 effect effect NN cord-344988-09vpehvf 236 17 of of IN cord-344988-09vpehvf 236 18 zinc zinc NN cord-344988-09vpehvf 236 19 on on IN cord-344988-09vpehvf 236 20 vaccination vaccination NN cord-344988-09vpehvf 236 21 in in IN cord-344988-09vpehvf 236 22 order order NN cord-344988-09vpehvf 236 23 to to TO cord-344988-09vpehvf 236 24 define define VB cord-344988-09vpehvf 236 25 an an DT cord-344988-09vpehvf 236 26 optimal optimal JJ cord-344988-09vpehvf 236 27 treatment treatment NN cord-344988-09vpehvf 236 28 protocol protocol NN cord-344988-09vpehvf 236 29 . . . cord-344988-09vpehvf 237 1 It -PRON- PRP cord-344988-09vpehvf 237 2 is be VBZ cord-344988-09vpehvf 237 3 well well RB cord-344988-09vpehvf 237 4 established establish VBN cord-344988-09vpehvf 237 5 that that IN cord-344988-09vpehvf 237 6 zinc zinc NN cord-344988-09vpehvf 237 7 status status NN cord-344988-09vpehvf 237 8 is be VBZ cord-344988-09vpehvf 237 9 an an DT cord-344988-09vpehvf 237 10 essential essential JJ cord-344988-09vpehvf 237 11 aspect aspect NN cord-344988-09vpehvf 237 12 of of IN cord-344988-09vpehvf 237 13 an an DT cord-344988-09vpehvf 237 14 intact intact JJ cord-344988-09vpehvf 237 15 immune immune JJ cord-344988-09vpehvf 237 16 system system NN cord-344988-09vpehvf 237 17 . . . cord-344988-09vpehvf 238 1 However however RB cord-344988-09vpehvf 238 2 , , , cord-344988-09vpehvf 238 3 in in IN cord-344988-09vpehvf 238 4 the the DT cord-344988-09vpehvf 238 5 studies study NNS cord-344988-09vpehvf 238 6 discussed discuss VBN cord-344988-09vpehvf 238 7 above above IN cord-344988-09vpehvf 238 8 it -PRON- PRP cord-344988-09vpehvf 238 9 could could MD cord-344988-09vpehvf 238 10 not not RB cord-344988-09vpehvf 238 11 always always RB cord-344988-09vpehvf 238 12 be be VB cord-344988-09vpehvf 238 13 distinguished distinguish VBN cord-344988-09vpehvf 238 14 if if IN cord-344988-09vpehvf 238 15 zinc zinc NN cord-344988-09vpehvf 238 16 acts act VBZ cord-344988-09vpehvf 238 17 solely solely RB cord-344988-09vpehvf 238 18 as as IN cord-344988-09vpehvf 238 19 an an DT cord-344988-09vpehvf 238 20 immune immune JJ cord-344988-09vpehvf 238 21 - - HYPH cord-344988-09vpehvf 238 22 modulator modulator NN cord-344988-09vpehvf 238 23 or or CC cord-344988-09vpehvf 238 24 to to TO cord-344988-09vpehvf 238 25 what what WDT cord-344988-09vpehvf 238 26 extent extent NN cord-344988-09vpehvf 238 27 other other JJ cord-344988-09vpehvf 238 28 functions function NNS cord-344988-09vpehvf 238 29 , , , cord-344988-09vpehvf 238 30 for for IN cord-344988-09vpehvf 238 31 example example NN cord-344988-09vpehvf 238 32 its -PRON- PRP$ cord-344988-09vpehvf 238 33 antioxidant antioxidant JJ cord-344988-09vpehvf 238 34 properties property NNS cord-344988-09vpehvf 238 35 , , , cord-344988-09vpehvf 238 36 contribute contribute VBP cord-344988-09vpehvf 238 37 to to IN cord-344988-09vpehvf 238 38 an an DT cord-344988-09vpehvf 238 39 in in IN cord-344988-09vpehvf 238 40 vivo vivo NN cord-344988-09vpehvf 238 41 effect effect NN cord-344988-09vpehvf 238 42 of of IN cord-344988-09vpehvf 238 43 zinc zinc NN cord-344988-09vpehvf 238 44 supple- supple- NN cord-344988-09vpehvf 239 1 Z Z NNP cord-344988-09vpehvf 239 2 -zinc -zinc NNP cord-344988-09vpehvf 239 3 , , , cord-344988-09vpehvf 239 4 P P NNP cord-344988-09vpehvf 239 5 -placebo -placebo NNP cord-344988-09vpehvf 239 6 , , , cord-344988-09vpehvf 239 7 C C NNP cord-344988-09vpehvf 239 8 -control -control NN cord-344988-09vpehvf 239 9 . . . cord-344988-09vpehvf 240 1 a a DT cord-344988-09vpehvf 240 2 Values value NNS cord-344988-09vpehvf 240 3 are be VBP cord-344988-09vpehvf 240 4 given give VBN cord-344988-09vpehvf 240 5 as as IN cord-344988-09vpehvf 240 6 the the DT cord-344988-09vpehvf 240 7 amount amount NN cord-344988-09vpehvf 240 8 of of IN cord-344988-09vpehvf 240 9 supplement supplement NN cord-344988-09vpehvf 240 10 unless unless IN cord-344988-09vpehvf 240 11 indicated indicate VBN cord-344988-09vpehvf 240 12 otherwise otherwise RB cord-344988-09vpehvf 240 13 . . . cord-344988-09vpehvf 241 1 The the DT cord-344988-09vpehvf 241 2 elemental elemental JJ cord-344988-09vpehvf 241 3 zinc zinc NN cord-344988-09vpehvf 241 4 content content NN cord-344988-09vpehvf 241 5 is be VBZ cord-344988-09vpehvf 241 6 given give VBN cord-344988-09vpehvf 241 7 as as IN cord-344988-09vpehvf 241 8 provided provide VBN cord-344988-09vpehvf 241 9 in in IN cord-344988-09vpehvf 241 10 the the DT cord-344988-09vpehvf 241 11 respective respective JJ cord-344988-09vpehvf 241 12 publication publication NN cord-344988-09vpehvf 241 13 and and CC cord-344988-09vpehvf 241 14 may may MD cord-344988-09vpehvf 241 15 not not RB cord-344988-09vpehvf 241 16 always always RB cord-344988-09vpehvf 241 17 correspond correspond VB cord-344988-09vpehvf 241 18 to to IN cord-344988-09vpehvf 241 19 Table Table NNP cord-344988-09vpehvf 241 20 1 1 CD cord-344988-09vpehvf 241 21 . . . cord-344988-09vpehvf 242 1 Fig Fig NNP cord-344988-09vpehvf 242 2 . . NNP cord-344988-09vpehvf 242 3 3 3 CD cord-344988-09vpehvf 242 4 . . . cord-344988-09vpehvf 243 1 Interaction interaction NN cord-344988-09vpehvf 243 2 between between IN cord-344988-09vpehvf 243 3 zinc zinc NN cord-344988-09vpehvf 243 4 homeostasis homeostasis NN cord-344988-09vpehvf 243 5 and and CC cord-344988-09vpehvf 243 6 disease disease NN cord-344988-09vpehvf 243 7 . . . cord-344988-09vpehvf 244 1 While while IN cord-344988-09vpehvf 244 2 many many JJ cord-344988-09vpehvf 244 3 diseases disease NNS cord-344988-09vpehvf 244 4 affect affect VBP cord-344988-09vpehvf 244 5 zinc zinc NN cord-344988-09vpehvf 244 6 homeostasis homeostasis NN cord-344988-09vpehvf 244 7 , , , cord-344988-09vpehvf 244 8 the the DT cord-344988-09vpehvf 244 9 latter latter NN cord-344988-09vpehvf 244 10 can can MD cord-344988-09vpehvf 244 11 modulate modulate VB cord-344988-09vpehvf 244 12 several several JJ cord-344988-09vpehvf 244 13 components component NNS cord-344988-09vpehvf 244 14 of of IN cord-344988-09vpehvf 244 15 the the DT cord-344988-09vpehvf 244 16 immune immune JJ cord-344988-09vpehvf 244 17 system system NN cord-344988-09vpehvf 244 18 , , , cord-344988-09vpehvf 244 19 but but CC cord-344988-09vpehvf 244 20 also also RB cord-344988-09vpehvf 244 21 general general JJ cord-344988-09vpehvf 244 22 metabolic metabolic JJ cord-344988-09vpehvf 244 23 processes process NNS cord-344988-09vpehvf 244 24 such such JJ cord-344988-09vpehvf 244 25 as as IN cord-344988-09vpehvf 244 26 the the DT cord-344988-09vpehvf 244 27 production production NN cord-344988-09vpehvf 244 28 of of IN cord-344988-09vpehvf 244 29 reactive reactive JJ cord-344988-09vpehvf 244 30 oxygen oxygen NN cord-344988-09vpehvf 244 31 species specie NNS cord-344988-09vpehvf 244 32 ( ( -LRB- cord-344988-09vpehvf 244 33 ROS ROS NNP cord-344988-09vpehvf 244 34 ) ) -RRB- cord-344988-09vpehvf 244 35 . . . cord-344988-09vpehvf 245 1 These these DT cord-344988-09vpehvf 245 2 can can MD cord-344988-09vpehvf 245 3 lead lead VB cord-344988-09vpehvf 245 4 to to IN cord-344988-09vpehvf 245 5 complications complication NNS cord-344988-09vpehvf 245 6 such such JJ cord-344988-09vpehvf 245 7 as as IN cord-344988-09vpehvf 245 8 secondary secondary JJ cord-344988-09vpehvf 245 9 infections infection NNS cord-344988-09vpehvf 245 10 and and CC cord-344988-09vpehvf 245 11 cellular cellular JJ cord-344988-09vpehvf 245 12 damage damage NN cord-344988-09vpehvf 245 13 , , , cord-344988-09vpehvf 245 14 but but CC cord-344988-09vpehvf 245 15 also also RB cord-344988-09vpehvf 245 16 contribute contribute VB cord-344988-09vpehvf 245 17 to to IN cord-344988-09vpehvf 245 18 the the DT cord-344988-09vpehvf 245 19 initial initial JJ cord-344988-09vpehvf 245 20 disease disease NN cord-344988-09vpehvf 245 21 . . . cord-344988-09vpehvf 246 1 mentation mentation NN cord-344988-09vpehvf 246 2 . . . cord-344988-09vpehvf 247 1 Due due IN cord-344988-09vpehvf 247 2 to to IN cord-344988-09vpehvf 247 3 the the DT cord-344988-09vpehvf 247 4 clear clear JJ cord-344988-09vpehvf 247 5 effects effect NNS cord-344988-09vpehvf 247 6 of of IN cord-344988-09vpehvf 247 7 zinc zinc NN cord-344988-09vpehvf 247 8 deficiency deficiency NN cord-344988-09vpehvf 247 9 and and CC cord-344988-09vpehvf 247 10 supplementation supplementation NN cord-344988-09vpehvf 247 11 on on IN cord-344988-09vpehvf 247 12 numerous numerous JJ cord-344988-09vpehvf 247 13 immune immune JJ cord-344988-09vpehvf 247 14 parameters parameter NNS cord-344988-09vpehvf 247 15 , , , cord-344988-09vpehvf 247 16 especially especially RB cord-344988-09vpehvf 247 17 pro pro JJ cord-344988-09vpehvf 247 18 - - JJ cord-344988-09vpehvf 247 19 inflammatory inflammatory JJ cord-344988-09vpehvf 247 20 cytokines cytokine NNS cord-344988-09vpehvf 247 21 and and CC cord-344988-09vpehvf 247 22 T t NN cord-344988-09vpehvf 247 23 lymphocytes lymphocyte NNS cord-344988-09vpehvf 247 24 , , , cord-344988-09vpehvf 247 25 it -PRON- PRP cord-344988-09vpehvf 247 26 can can MD cord-344988-09vpehvf 247 27 be be VB cord-344988-09vpehvf 247 28 safely safely RB cord-344988-09vpehvf 247 29 assumed assume VBN cord-344988-09vpehvf 247 30 that that IN cord-344988-09vpehvf 247 31 its -PRON- PRP$ cord-344988-09vpehvf 247 32 effect effect NN cord-344988-09vpehvf 247 33 on on IN cord-344988-09vpehvf 247 34 the the DT cord-344988-09vpehvf 247 35 immune immune JJ cord-344988-09vpehvf 247 36 system system NN cord-344988-09vpehvf 247 37 contributes contribute VBZ cord-344988-09vpehvf 247 38 significantly significantly RB cord-344988-09vpehvf 247 39 to to IN cord-344988-09vpehvf 247 40 the the DT cord-344988-09vpehvf 247 41 results result NNS cord-344988-09vpehvf 247 42 observed observe VBN cord-344988-09vpehvf 247 43 in in IN cord-344988-09vpehvf 247 44 supplementation supplementation NN cord-344988-09vpehvf 247 45 trials trial NNS cord-344988-09vpehvf 247 46 for for IN cord-344988-09vpehvf 247 47 different different JJ cord-344988-09vpehvf 247 48 diseases disease NNS cord-344988-09vpehvf 247 49 . . . cord-344988-09vpehvf 248 1 In in IN cord-344988-09vpehvf 248 2 most most JJS cord-344988-09vpehvf 248 3 cases case NNS cord-344988-09vpehvf 248 4 it -PRON- PRP cord-344988-09vpehvf 248 5 is be VBZ cord-344988-09vpehvf 248 6 not not RB cord-344988-09vpehvf 248 7 known know VBN cord-344988-09vpehvf 248 8 to to TO cord-344988-09vpehvf 248 9 what what WDT cord-344988-09vpehvf 248 10 extent extent NN cord-344988-09vpehvf 248 11 zinc zinc NN cord-344988-09vpehvf 248 12 deficiency deficiency NN cord-344988-09vpehvf 248 13 is be VBZ cord-344988-09vpehvf 248 14 causal causal JJ cord-344988-09vpehvf 248 15 for for IN cord-344988-09vpehvf 248 16 a a DT cord-344988-09vpehvf 248 17 disease disease NN cord-344988-09vpehvf 248 18 or or CC cord-344988-09vpehvf 248 19 if if IN cord-344988-09vpehvf 248 20 it -PRON- PRP cord-344988-09vpehvf 248 21 occurs occur VBZ cord-344988-09vpehvf 248 22 secondary secondary JJ cord-344988-09vpehvf 248 23 to to IN cord-344988-09vpehvf 248 24 the the DT cord-344988-09vpehvf 248 25 disease disease NN cord-344988-09vpehvf 248 26 and and CC cord-344988-09vpehvf 248 27 only only RB cord-344988-09vpehvf 248 28 contributes contribute VBZ cord-344988-09vpehvf 248 29 to to IN cord-344988-09vpehvf 248 30 its -PRON- PRP$ cord-344988-09vpehvf 248 31 severity severity NN cord-344988-09vpehvf 248 32 or or CC cord-344988-09vpehvf 248 33 the the DT cord-344988-09vpehvf 248 34 occurrence occurrence NN cord-344988-09vpehvf 248 35 of of IN cord-344988-09vpehvf 248 36 complications complication NNS cord-344988-09vpehvf 248 37 or or CC cord-344988-09vpehvf 248 38 secondary secondary JJ cord-344988-09vpehvf 248 39 infections infection NNS cord-344988-09vpehvf 249 1 ( ( -LRB- cord-344988-09vpehvf 249 2 Fig Fig NNP cord-344988-09vpehvf 249 3 . . . cord-344988-09vpehvf 249 4 3 3 CD cord-344988-09vpehvf 249 5 ) ) -RRB- cord-344988-09vpehvf 249 6 . . . cord-344988-09vpehvf 250 1 In in IN cord-344988-09vpehvf 250 2 any any DT cord-344988-09vpehvf 250 3 event event NN cord-344988-09vpehvf 250 4 , , , cord-344988-09vpehvf 250 5 zinc zinc NN cord-344988-09vpehvf 250 6 supplementation supplementation NN cord-344988-09vpehvf 250 7 can can MD cord-344988-09vpehvf 250 8 be be VB cord-344988-09vpehvf 250 9 effective effective JJ cord-344988-09vpehvf 250 10 in in IN cord-344988-09vpehvf 250 11 correcting correct VBG cord-344988-09vpehvf 250 12 both both DT cord-344988-09vpehvf 250 13 states state NNS cord-344988-09vpehvf 250 14 . . . cord-344988-09vpehvf 251 1 Therapeutic therapeutic JJ cord-344988-09vpehvf 251 2 zinc zinc NN cord-344988-09vpehvf 251 3 supplementation supplementation NN cord-344988-09vpehvf 251 4 in in IN cord-344988-09vpehvf 251 5 diseases disease NNS cord-344988-09vpehvf 251 6 such such JJ cord-344988-09vpehvf 251 7 as as IN cord-344988-09vpehvf 251 8 acute acute JJ cord-344988-09vpehvf 251 9 lower low JJR cord-344988-09vpehvf 251 10 respiratory respiratory JJ cord-344988-09vpehvf 251 11 infection infection NN cord-344988-09vpehvf 251 12 , , , cord-344988-09vpehvf 251 13 chronic chronic JJ cord-344988-09vpehvf 251 14 hepatitis hepatitis NN cord-344988-09vpehvf 251 15 C c NN cord-344988-09vpehvf 251 16 , , , cord-344988-09vpehvf 251 17 diarrhea diarrhea NN cord-344988-09vpehvf 251 18 , , , cord-344988-09vpehvf 251 19 shigellosis shigellosis NN cord-344988-09vpehvf 251 20 , , , cord-344988-09vpehvf 251 21 leprosy leprosy NN cord-344988-09vpehvf 251 22 , , , cord-344988-09vpehvf 251 23 tuberculosis tuberculosis NN cord-344988-09vpehvf 251 24 , , , cord-344988-09vpehvf 251 25 and and CC cord-344988-09vpehvf 251 26 acute acute JJ cord-344988-09vpehvf 251 27 cutaneous cutaneous JJ cord-344988-09vpehvf 251 28 leishmaniasis leishmaniasis NN cord-344988-09vpehvf 251 29 is be VBZ cord-344988-09vpehvf 251 30 beneficial beneficial JJ cord-344988-09vpehvf 251 31 . . . cord-344988-09vpehvf 252 1 Unfortunately unfortunately RB cord-344988-09vpehvf 252 2 , , , cord-344988-09vpehvf 252 3 these these DT cord-344988-09vpehvf 252 4 observations observation NNS cord-344988-09vpehvf 252 5 can can MD cord-344988-09vpehvf 252 6 not not RB cord-344988-09vpehvf 252 7 be be VB cord-344988-09vpehvf 252 8 generalized generalize VBN cord-344988-09vpehvf 252 9 . . . cord-344988-09vpehvf 253 1 The the DT cord-344988-09vpehvf 253 2 results result NNS cord-344988-09vpehvf 253 3 for for IN cord-344988-09vpehvf 253 4 the the DT cord-344988-09vpehvf 253 5 common common JJ cord-344988-09vpehvf 253 6 cold cold NN cord-344988-09vpehvf 253 7 and and CC cord-344988-09vpehvf 253 8 malaria malaria NN cord-344988-09vpehvf 253 9 are be VBP cord-344988-09vpehvf 253 10 still still RB cord-344988-09vpehvf 253 11 not not RB cord-344988-09vpehvf 253 12 conclusive conclusive JJ cord-344988-09vpehvf 253 13 , , , cord-344988-09vpehvf 253 14 and and CC cord-344988-09vpehvf 253 15 zinc zinc NN cord-344988-09vpehvf 253 16 was be VBD cord-344988-09vpehvf 253 17 ineffective ineffective JJ cord-344988-09vpehvf 253 18 in in IN cord-344988-09vpehvf 253 19 many many JJ cord-344988-09vpehvf 253 20 vaccination vaccination NN cord-344988-09vpehvf 253 21 trials trial NNS cord-344988-09vpehvf 253 22 as as RB cord-344988-09vpehvf 253 23 well well RB cord-344988-09vpehvf 253 24 as as IN cord-344988-09vpehvf 253 25 most most JJS cord-344988-09vpehvf 253 26 RA RA NNP cord-344988-09vpehvf 253 27 studies study NNS cord-344988-09vpehvf 253 28 . . . cord-344988-09vpehvf 254 1 It -PRON- PRP cord-344988-09vpehvf 254 2 is be VBZ cord-344988-09vpehvf 254 3 unclear unclear JJ cord-344988-09vpehvf 254 4 if if IN cord-344988-09vpehvf 254 5 this this DT cord-344988-09vpehvf 254 6 can can MD cord-344988-09vpehvf 254 7 be be VB cord-344988-09vpehvf 254 8 overcome overcome VBN cord-344988-09vpehvf 254 9 by by IN cord-344988-09vpehvf 254 10 changes change NNS cord-344988-09vpehvf 254 11 in in IN cord-344988-09vpehvf 254 12 dosage dosage NN cord-344988-09vpehvf 254 13 or or CC cord-344988-09vpehvf 254 14 duration duration NN cord-344988-09vpehvf 254 15 . . . cord-344988-09vpehvf 255 1 In in IN cord-344988-09vpehvf 255 2 AIDS AIDS NNP cord-344988-09vpehvf 255 3 and and CC cord-344988-09vpehvf 255 4 type type NN cord-344988-09vpehvf 255 5 1 1 CD cord-344988-09vpehvf 255 6 diabetes diabetes NN cord-344988-09vpehvf 255 7 , , , cord-344988-09vpehvf 255 8 zinc zinc NN cord-344988-09vpehvf 255 9 supplementation supplementation NN cord-344988-09vpehvf 255 10 may may MD cord-344988-09vpehvf 255 11 even even RB cord-344988-09vpehvf 255 12 be be VB cord-344988-09vpehvf 255 13 a a DT cord-344988-09vpehvf 255 14 risk risk NN cord-344988-09vpehvf 255 15 factor factor NN cord-344988-09vpehvf 255 16 for for IN cord-344988-09vpehvf 255 17 increased increase VBN cord-344988-09vpehvf 255 18 mortality mortality NN cord-344988-09vpehvf 255 19 or or CC cord-344988-09vpehvf 255 20 deterioration deterioration NN cord-344988-09vpehvf 255 21 of of IN cord-344988-09vpehvf 255 22 the the DT cord-344988-09vpehvf 255 23 glucose glucose NN cord-344988-09vpehvf 255 24 metabolism metabolism NN cord-344988-09vpehvf 255 25 , , , cord-344988-09vpehvf 255 26 respectively respectively RB cord-344988-09vpehvf 255 27 . . . cord-344988-09vpehvf 256 1 In in IN cord-344988-09vpehvf 256 2 these these DT cord-344988-09vpehvf 256 3 cases case NNS cord-344988-09vpehvf 256 4 , , , cord-344988-09vpehvf 256 5 zinc zinc NN cord-344988-09vpehvf 256 6 supplementation supplementation NN cord-344988-09vpehvf 256 7 should should MD cord-344988-09vpehvf 256 8 be be VB cord-344988-09vpehvf 256 9 avoided avoid VBN cord-344988-09vpehvf 256 10 , , , cord-344988-09vpehvf 256 11 or or CC cord-344988-09vpehvf 256 12 at at IN cord-344988-09vpehvf 256 13 least least JJS cord-344988-09vpehvf 256 14 limited limited JJ cord-344988-09vpehvf 256 15 to to TO cord-344988-09vpehvf 256 16 clearly clearly RB cord-344988-09vpehvf 256 17 zinc-- zinc-- VB cord-344988-09vpehvf 257 1 deficient deficient JJ cord-344988-09vpehvf 257 2 individuals individual NNS cord-344988-09vpehvf 257 3 . . . cord-344988-09vpehvf 258 1 Future future JJ cord-344988-09vpehvf 258 2 work work NN cord-344988-09vpehvf 258 3 should should MD cord-344988-09vpehvf 258 4 aim aim VB cord-344988-09vpehvf 258 5 at at IN cord-344988-09vpehvf 258 6 two two CD cord-344988-09vpehvf 258 7 aspects aspect NNS cord-344988-09vpehvf 258 8 . . . cord-344988-09vpehvf 259 1 First first RB cord-344988-09vpehvf 259 2 , , , cord-344988-09vpehvf 259 3 by by IN cord-344988-09vpehvf 259 4 paying pay VBG cord-344988-09vpehvf 259 5 more more JJR cord-344988-09vpehvf 259 6 attention attention NN cord-344988-09vpehvf 259 7 to to IN cord-344988-09vpehvf 259 8 zinc zinc NN cord-344988-09vpehvf 259 9 dosage dosage NN cord-344988-09vpehvf 259 10 and and CC cord-344988-09vpehvf 259 11 the the DT cord-344988-09vpehvf 259 12 patient patient NN cord-344988-09vpehvf 259 13 's 's POS cord-344988-09vpehvf 259 14 zinc zinc NN cord-344988-09vpehvf 259 15 status status NN cord-344988-09vpehvf 259 16 before before IN cord-344988-09vpehvf 259 17 and and CC cord-344988-09vpehvf 259 18 during during IN cord-344988-09vpehvf 259 19 the the DT cord-344988-09vpehvf 259 20 supplementation supplementation NN cord-344988-09vpehvf 259 21 , , , cord-344988-09vpehvf 259 22 it -PRON- PRP cord-344988-09vpehvf 259 23 should should MD cord-344988-09vpehvf 259 24 be be VB cord-344988-09vpehvf 259 25 possible possible JJ cord-344988-09vpehvf 259 26 to to TO cord-344988-09vpehvf 259 27 administer administer VB cord-344988-09vpehvf 259 28 the the DT cord-344988-09vpehvf 259 29 optimal optimal JJ cord-344988-09vpehvf 259 30 amount amount NN cord-344988-09vpehvf 259 31 of of IN cord-344988-09vpehvf 259 32 zinc zinc NN cord-344988-09vpehvf 259 33 and and CC cord-344988-09vpehvf 259 34 thereby thereby RB cord-344988-09vpehvf 259 35 significantly significantly RB cord-344988-09vpehvf 259 36 improve improve VB cord-344988-09vpehvf 259 37 the the DT cord-344988-09vpehvf 259 38 therapeutic therapeutic JJ cord-344988-09vpehvf 259 39 effects effect NNS cord-344988-09vpehvf 259 40 . . . cord-344988-09vpehvf 260 1 Here here RB cord-344988-09vpehvf 260 2 the the DT cord-344988-09vpehvf 260 3 standard standard JJ cord-344988-09vpehvf 260 4 parameter parameter NN cord-344988-09vpehvf 260 5 , , , cord-344988-09vpehvf 260 6 i.e. i.e. FW cord-344988-09vpehvf 260 7 total total JJ cord-344988-09vpehvf 260 8 serum serum NN cord-344988-09vpehvf 260 9 or or CC cord-344988-09vpehvf 260 10 plasma plasma NN cord-344988-09vpehvf 260 11 zinc zinc NN cord-344988-09vpehvf 260 12 , , , cord-344988-09vpehvf 260 13 does do VBZ cord-344988-09vpehvf 260 14 not not RB cord-344988-09vpehvf 260 15 adequately adequately RB cord-344988-09vpehvf 260 16 reflect reflect VB cord-344988-09vpehvf 260 17 the the DT cord-344988-09vpehvf 260 18 patient patient NN cord-344988-09vpehvf 260 19 's 's POS cord-344988-09vpehvf 260 20 zinc zinc NN cord-344988-09vpehvf 260 21 status status NN cord-344988-09vpehvf 260 22 , , , cord-344988-09vpehvf 260 23 but but CC cord-344988-09vpehvf 260 24 the the DT cord-344988-09vpehvf 260 25 development development NN cord-344988-09vpehvf 260 26 of of IN cord-344988-09vpehvf 260 27 new new JJ cord-344988-09vpehvf 260 28 methods method NNS cord-344988-09vpehvf 260 29 such such JJ cord-344988-09vpehvf 260 30 as as IN cord-344988-09vpehvf 260 31 the the DT cord-344988-09vpehvf 260 32 use use NN cord-344988-09vpehvf 260 33 of of IN cord-344988-09vpehvf 260 34 fluorescent fluorescent JJ cord-344988-09vpehvf 260 35 probes probe NNS cord-344988-09vpehvf 260 36 for for IN cord-344988-09vpehvf 260 37 the the DT cord-344988-09vpehvf 260 38 measurement measurement NN cord-344988-09vpehvf 260 39 of of IN cord-344988-09vpehvf 260 40 labile labile JJ cord-344988-09vpehvf 260 41 intracellular intracellular JJ cord-344988-09vpehvf 260 42 zinc zinc NN cord-344988-09vpehvf 260 43 [ [ -LRB- cord-344988-09vpehvf 260 44 56 56 CD cord-344988-09vpehvf 260 45 ] ] -RRB- cord-344988-09vpehvf 260 46 may may MD cord-344988-09vpehvf 260 47 lead lead VB cord-344988-09vpehvf 260 48 to to IN cord-344988-09vpehvf 260 49 improvement improvement NN cord-344988-09vpehvf 260 50 . . . cord-344988-09vpehvf 261 1 Secondly secondly RB cord-344988-09vpehvf 261 2 , , , cord-344988-09vpehvf 261 3 elucidating elucidate VBG cord-344988-09vpehvf 261 4 the the DT cord-344988-09vpehvf 261 5 molecular molecular JJ cord-344988-09vpehvf 261 6 mechanisms mechanism NNS cord-344988-09vpehvf 261 7 by by IN cord-344988-09vpehvf 261 8 which which WDT cord-344988-09vpehvf 261 9 zinc zinc NN cord-344988-09vpehvf 261 10 acts act NNS cord-344988-09vpehvf 261 11 will will MD cord-344988-09vpehvf 261 12 help help VB cord-344988-09vpehvf 261 13 to to TO cord-344988-09vpehvf 261 14 provide provide VB cord-344988-09vpehvf 261 15 a a DT cord-344988-09vpehvf 261 16 successful successful JJ cord-344988-09vpehvf 261 17 treatment treatment NN cord-344988-09vpehvf 261 18 , , , cord-344988-09vpehvf 261 19 in in IN cord-344988-09vpehvf 261 20 particular particular JJ cord-344988-09vpehvf 261 21 when when WRB cord-344988-09vpehvf 261 22 zinc zinc NN cord-344988-09vpehvf 261 23 is be VBZ cord-344988-09vpehvf 261 24 given give VBN cord-344988-09vpehvf 261 25 in in IN cord-344988-09vpehvf 261 26 combination combination NN cord-344988-09vpehvf 261 27 with with IN cord-344988-09vpehvf 261 28 other other JJ cord-344988-09vpehvf 261 29 substances substance NNS cord-344988-09vpehvf 261 30 . . . cord-344988-09vpehvf 262 1 Here here RB cord-344988-09vpehvf 262 2 an an DT cord-344988-09vpehvf 262 3 important important JJ cord-344988-09vpehvf 262 4 first first JJ cord-344988-09vpehvf 262 5 step step NN cord-344988-09vpehvf 262 6 will will MD cord-344988-09vpehvf 262 7 be be VB cord-344988-09vpehvf 262 8 evaluating evaluate VBG cord-344988-09vpehvf 262 9 which which WDT cord-344988-09vpehvf 262 10 in in IN cord-344988-09vpehvf 262 11 vitro vitro FW cord-344988-09vpehvf 262 12 observations observation NNS cord-344988-09vpehvf 262 13 are be VBP cord-344988-09vpehvf 262 14 relevant relevant JJ cord-344988-09vpehvf 262 15 . . . cord-344988-09vpehvf 263 1 Given give VBN cord-344988-09vpehvf 263 2 that that IN cord-344988-09vpehvf 263 3 many many JJ cord-344988-09vpehvf 263 4 effects effect NNS cord-344988-09vpehvf 263 5 can can MD cord-344988-09vpehvf 263 6 only only RB cord-344988-09vpehvf 263 7 be be VB cord-344988-09vpehvf 263 8 seen see VBN cord-344988-09vpehvf 263 9 when when WRB cord-344988-09vpehvf 263 10 supra supra JJ cord-344988-09vpehvf 263 11 - - HYPH cord-344988-09vpehvf 263 12 physiological physiological JJ cord-344988-09vpehvf 263 13 concentrations concentration NNS cord-344988-09vpehvf 263 14 of of IN cord-344988-09vpehvf 263 15 zinc zinc NN cord-344988-09vpehvf 263 16 are be VBP cord-344988-09vpehvf 263 17 used use VBN cord-344988-09vpehvf 263 18 , , , cord-344988-09vpehvf 263 19 as as IN cord-344988-09vpehvf 263 20 in in IN cord-344988-09vpehvf 263 21 the the DT cord-344988-09vpehvf 263 22 different different JJ cord-344988-09vpehvf 263 23 cases case NNS cord-344988-09vpehvf 263 24 of of IN cord-344988-09vpehvf 263 25 the the DT cord-344988-09vpehvf 263 26 inhibition inhibition NN cord-344988-09vpehvf 263 27 of of IN cord-344988-09vpehvf 263 28 viral viral JJ cord-344988-09vpehvf 263 29 replication replication NN cord-344988-09vpehvf 263 30 , , , cord-344988-09vpehvf 263 31 the the DT cord-344988-09vpehvf 263 32 likelihood likelihood NN cord-344988-09vpehvf 263 33 for for IN cord-344988-09vpehvf 263 34 an an DT cord-344988-09vpehvf 263 35 in in IN cord-344988-09vpehvf 263 36 vivo vivo NN cord-344988-09vpehvf 263 37 relevance relevance NN cord-344988-09vpehvf 263 38 is be VBZ cord-344988-09vpehvf 263 39 questionable questionable JJ cord-344988-09vpehvf 263 40 . . . cord-344988-09vpehvf 264 1 There there EX cord-344988-09vpehvf 264 2 is be VBZ cord-344988-09vpehvf 264 3 still still RB cord-344988-09vpehvf 264 4 great great JJ cord-344988-09vpehvf 264 5 potential potential NN cord-344988-09vpehvf 264 6 for for IN cord-344988-09vpehvf 264 7 improving improve VBG cord-344988-09vpehvf 264 8 the the DT cord-344988-09vpehvf 264 9 use use NN cord-344988-09vpehvf 264 10 of of IN cord-344988-09vpehvf 264 11 zinc zinc NN cord-344988-09vpehvf 264 12 as as IN cord-344988-09vpehvf 264 13 a a DT cord-344988-09vpehvf 264 14 therapeutic therapeutic JJ cord-344988-09vpehvf 264 15 agent agent NN cord-344988-09vpehvf 264 16 and and CC cord-344988-09vpehvf 264 17 successful successful JJ cord-344988-09vpehvf 264 18 application application NN cord-344988-09vpehvf 264 19 for for IN cord-344988-09vpehvf 264 20 the the DT cord-344988-09vpehvf 264 21 modulation modulation NN cord-344988-09vpehvf 264 22 of of IN cord-344988-09vpehvf 264 23 the the DT cord-344988-09vpehvf 264 24 immune immune JJ cord-344988-09vpehvf 264 25 response response NN cord-344988-09vpehvf 264 26 . . . cord-344988-09vpehvf 265 1 Rheumatoid rheumatoid JJ cord-344988-09vpehvf 265 2 arthritis arthritis NN cord-344988-09vpehvf 265 3 and and CC cord-344988-09vpehvf 265 4 metal metal NN cord-344988-09vpehvf 265 5 compounds compound NNS cord-344988-09vpehvf 266 1 -perspectives -perspectives . cord-344988-09vpehvf 267 1 on on IN cord-344988-09vpehvf 267 2 the the DT cord-344988-09vpehvf 267 3 role role NN cord-344988-09vpehvf 267 4 of of IN cord-344988-09vpehvf 267 5 oxygen oxygen NN cord-344988-09vpehvf 267 6 radical radical JJ cord-344988-09vpehvf 267 7 detoxification detoxification NN cord-344988-09vpehvf 268 1 The the DT cord-344988-09vpehvf 268 2 assessment assessment NN cord-344988-09vpehvf 268 3 of of IN cord-344988-09vpehvf 268 4 zinc zinc NN cord-344988-09vpehvf 268 5 status status NN cord-344988-09vpehvf 268 6 : : : cord-344988-09vpehvf 268 7 a a DT cord-344988-09vpehvf 268 8 personal personal JJ cord-344988-09vpehvf 268 9 view view NN cord-344988-09vpehvf 268 10 Enteric enteric JJ cord-344988-09vpehvf 268 11 protein protein NN cord-344988-09vpehvf 268 12 loss loss NN cord-344988-09vpehvf 268 13 and and CC cord-344988-09vpehvf 268 14 intestinal intestinal JJ cord-344988-09vpehvf 268 15 permeability permeability NN cord-344988-09vpehvf 268 16 changes change NNS cord-344988-09vpehvf 268 17 in in IN cord-344988-09vpehvf 268 18 children child NNS cord-344988-09vpehvf 268 19 during during IN cord-344988-09vpehvf 268 20 acute acute JJ cord-344988-09vpehvf 268 21 shigellosis shigellosis NN cord-344988-09vpehvf 268 22 and and CC cord-344988-09vpehvf 268 23 after after IN cord-344988-09vpehvf 268 24 recovery recovery NN cord-344988-09vpehvf 268 25 : : : cord-344988-09vpehvf 268 26 effect effect NN cord-344988-09vpehvf 268 27 of of IN cord-344988-09vpehvf 268 28 zinc zinc NN cord-344988-09vpehvf 268 29 supplementation supplementation NN cord-344988-09vpehvf 268 30 Supplementation Supplementation NNP cord-344988-09vpehvf 268 31 with with IN cord-344988-09vpehvf 268 32 zinc zinc NN cord-344988-09vpehvf 268 33 , , , cord-344988-09vpehvf 268 34 but but CC cord-344988-09vpehvf 268 35 not not RB cord-344988-09vpehvf 268 36 vitamin vitamin NN cord-344988-09vpehvf 268 37 A a NN cord-344988-09vpehvf 268 38 , , , cord-344988-09vpehvf 268 39 improves improve VBZ cord-344988-09vpehvf 268 40 seroconversion seroconversion NN cord-344988-09vpehvf 268 41 to to IN cord-344988-09vpehvf 268 42 vibriocidal vibriocidal JJ cord-344988-09vpehvf 268 43 antibody antibody NN cord-344988-09vpehvf 268 44 in in IN cord-344988-09vpehvf 268 45 children child NNS cord-344988-09vpehvf 268 46 given give VBN cord-344988-09vpehvf 268 47 an an DT cord-344988-09vpehvf 268 48 oral oral JJ cord-344988-09vpehvf 268 49 cholera cholera NN cord-344988-09vpehvf 268 50 vaccine vaccine NN cord-344988-09vpehvf 269 1 The the DT cord-344988-09vpehvf 269 2 mechanism mechanism NN cord-344988-09vpehvf 269 3 behind behind IN cord-344988-09vpehvf 269 4 the the DT cord-344988-09vpehvf 269 5 antileishmanial antileishmanial JJ cord-344988-09vpehvf 269 6 effect effect NN cord-344988-09vpehvf 269 7 of of IN cord-344988-09vpehvf 269 8 zinc zinc NN cord-344988-09vpehvf 269 9 sulphate sulphate NN cord-344988-09vpehvf 270 1 The the DT cord-344988-09vpehvf 270 2 mechanism mechanism NN cord-344988-09vpehvf 270 3 behind behind IN cord-344988-09vpehvf 270 4 the the DT cord-344988-09vpehvf 270 5 antileishmanial antileishmanial JJ cord-344988-09vpehvf 270 6 effect effect NN cord-344988-09vpehvf 270 7 of of IN cord-344988-09vpehvf 270 8 zinc zinc NN cord-344988-09vpehvf 270 9 sulphate sulphate NN cord-344988-09vpehvf 270 10 . . . cord-344988-09vpehvf 271 1 I. I. NNP cord-344988-09vpehvf 272 1 An an DT cord-344988-09vpehvf 272 2 in in IN cord-344988-09vpehvf 272 3 - - HYPH cord-344988-09vpehvf 272 4 vitro vitro FW cord-344988-09vpehvf 272 5 study study NN cord-344988-09vpehvf 272 6 Zinc Zinc NNP cord-344988-09vpehvf 272 7 coordination coordination NN cord-344988-09vpehvf 272 8 sphere sphere NN cord-344988-09vpehvf 272 9 in in IN cord-344988-09vpehvf 272 10 biochemical biochemical JJ cord-344988-09vpehvf 272 11 zinc zinc NN cord-344988-09vpehvf 272 12 sites site NNS cord-344988-09vpehvf 273 1 Zinc zinc NN cord-344988-09vpehvf 273 2 modulates modulate VBZ cord-344988-09vpehvf 273 3 mRNA mrna NN cord-344988-09vpehvf 273 4 levels level NNS cord-344988-09vpehvf 273 5 of of IN cord-344988-09vpehvf 273 6 cytokines cytokine NNS cord-344988-09vpehvf 274 1 A a DT cord-344988-09vpehvf 274 2 trial trial NN cord-344988-09vpehvf 274 3 of of IN cord-344988-09vpehvf 274 4 zinc zinc NN cord-344988-09vpehvf 274 5 supplementation supplementation NN cord-344988-09vpehvf 274 6 in in IN cord-344988-09vpehvf 274 7 young young JJ cord-344988-09vpehvf 274 8 rural rural JJ cord-344988-09vpehvf 274 9 Gambian gambian JJ cord-344988-09vpehvf 274 10 children child NNS cord-344988-09vpehvf 274 11 Changes change NNS cord-344988-09vpehvf 274 12 in in IN cord-344988-09vpehvf 274 13 cytokine cytokine NN cord-344988-09vpehvf 274 14 production production NN cord-344988-09vpehvf 274 15 and and CC cord-344988-09vpehvf 274 16 T t NN cord-344988-09vpehvf 274 17 cell cell NN cord-344988-09vpehvf 274 18 subpopulations subpopulation NNS cord-344988-09vpehvf 274 19 in in IN cord-344988-09vpehvf 274 20 experimentally experimentally RB cord-344988-09vpehvf 274 21 induced induce VBN cord-344988-09vpehvf 274 22 zinc zinc NN cord-344988-09vpehvf 274 23 - - HYPH cord-344988-09vpehvf 274 24 deficient deficient JJ cord-344988-09vpehvf 274 25 humans human NNS cord-344988-09vpehvf 274 26 Zinc Zinc NNP cord-344988-09vpehvf 274 27 potentiates potentiate VBZ cord-344988-09vpehvf 274 28 the the DT cord-344988-09vpehvf 274 29 antiviral antiviral JJ cord-344988-09vpehvf 274 30 action action NN cord-344988-09vpehvf 274 31 of of IN cord-344988-09vpehvf 274 32 human human JJ cord-344988-09vpehvf 274 33 IFN IFN NNP cord-344988-09vpehvf 274 34 - - HYPH cord-344988-09vpehvf 274 35 alpha alpha NN cord-344988-09vpehvf 274 36 tenfold tenfold RB cord-344988-09vpehvf 275 1 A a DT cord-344988-09vpehvf 275 2 critical critical JJ cord-344988-09vpehvf 275 3 physiological physiological JJ cord-344988-09vpehvf 275 4 role role NN cord-344988-09vpehvf 275 5 of of IN cord-344988-09vpehvf 275 6 zinc zinc NN cord-344988-09vpehvf 275 7 in in IN cord-344988-09vpehvf 275 8 the the DT cord-344988-09vpehvf 275 9 structure structure NN cord-344988-09vpehvf 275 10 and and CC cord-344988-09vpehvf 275 11 function function NN cord-344988-09vpehvf 275 12 of of IN cord-344988-09vpehvf 275 13 biomembranes biomembranes NNPS cord-344988-09vpehvf 275 14 Functions Functions NNPS cord-344988-09vpehvf 275 15 of of IN cord-344988-09vpehvf 275 16 zinc zinc NN cord-344988-09vpehvf 275 17 in in IN cord-344988-09vpehvf 275 18 signaling signaling NN cord-344988-09vpehvf 275 19 , , , cord-344988-09vpehvf 275 20 proliferation proliferation NN cord-344988-09vpehvf 275 21 and and CC cord-344988-09vpehvf 275 22 differentiation differentiation NN cord-344988-09vpehvf 275 23 of of IN cord-344988-09vpehvf 275 24 mammalian mammalian JJ cord-344988-09vpehvf 275 25 cells cell NNS cord-344988-09vpehvf 275 26 Prevention prevention NN cord-344988-09vpehvf 275 27 of of IN cord-344988-09vpehvf 275 28 diarrhea diarrhea NN cord-344988-09vpehvf 275 29 and and CC cord-344988-09vpehvf 275 30 pneumonia pneumonia NN cord-344988-09vpehvf 275 31 by by IN cord-344988-09vpehvf 275 32 zinc zinc NN cord-344988-09vpehvf 275 33 supplementation supplementation NN cord-344988-09vpehvf 275 34 in in IN cord-344988-09vpehvf 275 35 children child NNS cord-344988-09vpehvf 275 36 in in IN cord-344988-09vpehvf 275 37 developing develop VBG cord-344988-09vpehvf 275 38 countries country NNS cord-344988-09vpehvf 275 39 : : : cord-344988-09vpehvf 275 40 pooled pool VBN cord-344988-09vpehvf 275 41 analysis analysis NN cord-344988-09vpehvf 275 42 of of IN cord-344988-09vpehvf 275 43 randomized randomized JJ cord-344988-09vpehvf 275 44 controlled control VBN cord-344988-09vpehvf 275 45 trials trial NNS cord-344988-09vpehvf 275 46 . . . cord-344988-09vpehvf 276 1 Zinc Zinc NNP cord-344988-09vpehvf 276 2 Investigators Investigators NNPS cord-344988-09vpehvf 276 3 ' ' POS cord-344988-09vpehvf 276 4 Collaborative Collaborative NNP cord-344988-09vpehvf 276 5 Group Group NNP cord-344988-09vpehvf 276 6 Therapeutic therapeutic JJ cord-344988-09vpehvf 276 7 effects effect NNS cord-344988-09vpehvf 276 8 of of IN cord-344988-09vpehvf 276 9 oral oral JJ cord-344988-09vpehvf 276 10 zinc zinc NN cord-344988-09vpehvf 276 11 in in IN cord-344988-09vpehvf 276 12 acute acute JJ cord-344988-09vpehvf 276 13 and and CC cord-344988-09vpehvf 276 14 persistent persistent JJ cord-344988-09vpehvf 276 15 diarrhea diarrhea NN cord-344988-09vpehvf 276 16 in in IN cord-344988-09vpehvf 276 17 children child NNS cord-344988-09vpehvf 276 18 in in IN cord-344988-09vpehvf 276 19 developing develop VBG cord-344988-09vpehvf 276 20 countries country NNS cord-344988-09vpehvf 276 21 : : : cord-344988-09vpehvf 276 22 pooled pool VBN cord-344988-09vpehvf 276 23 analysis analysis NN cord-344988-09vpehvf 276 24 of of IN cord-344988-09vpehvf 276 25 randomized randomized JJ cord-344988-09vpehvf 276 26 controlled control VBN cord-344988-09vpehvf 276 27 trials trial NNS cord-344988-09vpehvf 276 28 Safety safety NN cord-344988-09vpehvf 276 29 and and CC cord-344988-09vpehvf 276 30 efficacy efficacy NN cord-344988-09vpehvf 276 31 of of IN cord-344988-09vpehvf 276 32 zinc zinc NN cord-344988-09vpehvf 276 33 supplementation supplementation NN cord-344988-09vpehvf 276 34 for for IN cord-344988-09vpehvf 276 35 children child NNS cord-344988-09vpehvf 276 36 with with IN cord-344988-09vpehvf 276 37 HIV-1 HIV-1 NNP cord-344988-09vpehvf 276 38 infection infection NN cord-344988-09vpehvf 276 39 in in IN cord-344988-09vpehvf 276 40 South South NNP cord-344988-09vpehvf 276 41 Africa Africa NNP cord-344988-09vpehvf 276 42 : : : cord-344988-09vpehvf 276 43 a a DT cord-344988-09vpehvf 276 44 randomised randomised JJ cord-344988-09vpehvf 276 45 double double JJ cord-344988-09vpehvf 276 46 -- -- : cord-344988-09vpehvf 276 47 blind blind JJ cord-344988-09vpehvf 276 48 placebo placebo NN cord-344988-09vpehvf 276 49 - - HYPH cord-344988-09vpehvf 276 50 controlled control VBN cord-344988-09vpehvf 276 51 trial trial NN cord-344988-09vpehvf 276 52 Nutrient Nutrient NNP cord-344988-09vpehvf 276 53 regulation regulation NN cord-344988-09vpehvf 276 54 of of IN cord-344988-09vpehvf 276 55 cell cell NN cord-344988-09vpehvf 276 56 cycle cycle NN cord-344988-09vpehvf 276 57 progression progression NN cord-344988-09vpehvf 277 1 The the DT cord-344988-09vpehvf 277 2 physiological physiological JJ cord-344988-09vpehvf 277 3 role role NN cord-344988-09vpehvf 277 4 of of IN cord-344988-09vpehvf 277 5 zinc zinc NN cord-344988-09vpehvf 277 6 as as IN cord-344988-09vpehvf 277 7 an an DT cord-344988-09vpehvf 277 8 antioxidant antioxidant NN cord-344988-09vpehvf 277 9 . . . cord-344988-09vpehvf 278 1 Free Free NNP cord-344988-09vpehvf 278 2 Radic Radic NNP cord-344988-09vpehvf 278 3 Zinc Zinc NNP cord-344988-09vpehvf 278 4 supplementation supplementation NN cord-344988-09vpehvf 278 5 reconstitutes reconstitute VBZ cord-344988-09vpehvf 278 6 the the DT cord-344988-09vpehvf 278 7 production production NN cord-344988-09vpehvf 278 8 of of IN cord-344988-09vpehvf 278 9 interferon interferon NN cord-344988-09vpehvf 278 10 - - HYPH cord-344988-09vpehvf 278 11 α α NN cord-344988-09vpehvf 278 12 by by IN cord-344988-09vpehvf 278 13 leukocytes leukocyte NNS cord-344988-09vpehvf 278 14 from from IN cord-344988-09vpehvf 278 15 elderly elderly JJ cord-344988-09vpehvf 278 16 persons person NNS cord-344988-09vpehvf 278 17 Dysregulation Dysregulation NNP cord-344988-09vpehvf 278 18 between between IN cord-344988-09vpehvf 278 19 TH1 TH1 NNP cord-344988-09vpehvf 278 20 and and CC cord-344988-09vpehvf 278 21 TH2 TH2 NNP cord-344988-09vpehvf 278 22 T T NNP cord-344988-09vpehvf 278 23 cell cell NN cord-344988-09vpehvf 278 24 subpopulations subpopulation NNS cord-344988-09vpehvf 278 25 in in IN cord-344988-09vpehvf 278 26 the the DT cord-344988-09vpehvf 278 27 elderly elderly JJ cord-344988-09vpehvf 278 28 Zinc zinc NN cord-344988-09vpehvf 278 29 , , , cord-344988-09vpehvf 278 30 insulin insulin NN cord-344988-09vpehvf 278 31 and and CC cord-344988-09vpehvf 278 32 diabetes diabetes NN cord-344988-09vpehvf 278 33 Changes change NNS cord-344988-09vpehvf 278 34 in in IN cord-344988-09vpehvf 278 35 serum serum NN cord-344988-09vpehvf 278 36 selenium selenium NN cord-344988-09vpehvf 278 37 , , , cord-344988-09vpehvf 278 38 copper copper NN cord-344988-09vpehvf 278 39 , , , cord-344988-09vpehvf 278 40 zinc zinc NN cord-344988-09vpehvf 278 41 levels level NNS cord-344988-09vpehvf 278 42 and and CC cord-344988-09vpehvf 278 43 Cu Cu NNP cord-344988-09vpehvf 278 44 / / SYM cord-344988-09vpehvf 278 45 Zn Zn NNP cord-344988-09vpehvf 278 46 ratio ratio NN cord-344988-09vpehvf 278 47 in in IN cord-344988-09vpehvf 278 48 patients patient NNS cord-344988-09vpehvf 278 49 with with IN cord-344988-09vpehvf 278 50 pulmonary pulmonary JJ cord-344988-09vpehvf 278 51 tuberculosis tuberculosis NN cord-344988-09vpehvf 278 52 during during IN cord-344988-09vpehvf 278 53 therapy therapy NN cord-344988-09vpehvf 278 54 Zinc Zinc NNP cord-344988-09vpehvf 278 55 deficiency deficiency NN cord-344988-09vpehvf 278 56 and and CC cord-344988-09vpehvf 278 57 supplementation supplementation NN cord-344988-09vpehvf 278 58 in in IN cord-344988-09vpehvf 279 1 HIV HIV NNP cord-344988-09vpehvf 279 2 / / SYM cord-344988-09vpehvf 279 3 AIDS AIDS NNP cord-344988-09vpehvf 279 4 Interleukin Interleukin NNP cord-344988-09vpehvf 279 5 1 1 CD cord-344988-09vpehvf 279 6 regulates regulate VBZ cord-344988-09vpehvf 279 7 secretion secretion NN cord-344988-09vpehvf 279 8 of of IN cord-344988-09vpehvf 279 9 zinc zinc NN cord-344988-09vpehvf 279 10 - - HYPH cord-344988-09vpehvf 279 11 thymulin thymulin NN cord-344988-09vpehvf 279 12 by by IN cord-344988-09vpehvf 279 13 human human JJ cord-344988-09vpehvf 279 14 thymic thymic JJ cord-344988-09vpehvf 279 15 epithelial epithelial JJ cord-344988-09vpehvf 279 16 cells cell NNS cord-344988-09vpehvf 279 17 and and CC cord-344988-09vpehvf 279 18 its -PRON- PRP$ cord-344988-09vpehvf 279 19 action action NN cord-344988-09vpehvf 279 20 on on IN cord-344988-09vpehvf 279 21 T T NNP cord-344988-09vpehvf 279 22 -- -- : cord-344988-09vpehvf 279 23 lymphocyte lymphocyte NN cord-344988-09vpehvf 279 24 proliferation proliferation NN cord-344988-09vpehvf 279 25 and and CC cord-344988-09vpehvf 279 26 nuclear nuclear JJ cord-344988-09vpehvf 279 27 protein protein NN cord-344988-09vpehvf 279 28 kinase kinase NN cord-344988-09vpehvf 279 29 C C NNP cord-344988-09vpehvf 279 30 Hyperzincuria Hyperzincuria NNP cord-344988-09vpehvf 279 31 in in IN cord-344988-09vpehvf 279 32 individuals individual NNS cord-344988-09vpehvf 279 33 with with IN cord-344988-09vpehvf 279 34 insulin insulin NN cord-344988-09vpehvf 279 35 - - HYPH cord-344988-09vpehvf 279 36 dependent dependent JJ cord-344988-09vpehvf 279 37 diabetes diabetes NN cord-344988-09vpehvf 279 38 mellitus mellitus NN cord-344988-09vpehvf 279 39 : : : cord-344988-09vpehvf 279 40 concurrent concurrent JJ cord-344988-09vpehvf 279 41 zinc zinc NN cord-344988-09vpehvf 279 42 status status NN cord-344988-09vpehvf 279 43 and and CC cord-344988-09vpehvf 279 44 the the DT cord-344988-09vpehvf 279 45 effect effect NN cord-344988-09vpehvf 279 46 of of IN cord-344988-09vpehvf 279 47 high high JJ cord-344988-09vpehvf 279 48 - - HYPH cord-344988-09vpehvf 279 49 dose dose NN cord-344988-09vpehvf 279 50 zinc zinc NN cord-344988-09vpehvf 279 51 supplementation supplementation NN cord-344988-09vpehvf 279 52 A a DT cord-344988-09vpehvf 279 53 zinc zinc NN cord-344988-09vpehvf 279 54 dependent dependent JJ cord-344988-09vpehvf 279 55 epitope epitope NN cord-344988-09vpehvf 279 56 of of IN cord-344988-09vpehvf 279 57 the the DT cord-344988-09vpehvf 279 58 molecule molecule NN cord-344988-09vpehvf 279 59 of of IN cord-344988-09vpehvf 279 60 thymulin thymulin NNP cord-344988-09vpehvf 279 61 , , , cord-344988-09vpehvf 279 62 a a DT cord-344988-09vpehvf 279 63 thymic thymic JJ cord-344988-09vpehvf 279 64 hormone hormone NN cord-344988-09vpehvf 279 65 Effect effect NN cord-344988-09vpehvf 279 66 of of IN cord-344988-09vpehvf 279 67 zinc zinc NN cord-344988-09vpehvf 279 68 and and CC cord-344988-09vpehvf 279 69 vitamin vitamin NN cord-344988-09vpehvf 279 70 A a DT cord-344988-09vpehvf 279 71 supplementation supplementation NN cord-344988-09vpehvf 279 72 on on IN cord-344988-09vpehvf 279 73 antibody antibody NN cord-344988-09vpehvf 279 74 responses response NNS cord-344988-09vpehvf 279 75 to to IN cord-344988-09vpehvf 279 76 a a DT cord-344988-09vpehvf 279 77 pneumococcal pneumococcal JJ cord-344988-09vpehvf 279 78 conjugate conjugate JJ cord-344988-09vpehvf 279 79 vaccine vaccine NN cord-344988-09vpehvf 279 80 in in IN cord-344988-09vpehvf 279 81 HIV HIV NNP cord-344988-09vpehvf 279 82 - - HYPH cord-344988-09vpehvf 279 83 positive positive JJ cord-344988-09vpehvf 279 84 injection injection NN cord-344988-09vpehvf 279 85 drug drug NN cord-344988-09vpehvf 279 86 users user NNS cord-344988-09vpehvf 279 87 : : : cord-344988-09vpehvf 280 1 a a DT cord-344988-09vpehvf 280 2 randomized randomized JJ cord-344988-09vpehvf 280 3 trial trial NN cord-344988-09vpehvf 280 4 Interference Interference NNP cord-344988-09vpehvf 280 5 in in IN cord-344988-09vpehvf 280 6 the the DT cord-344988-09vpehvf 280 7 development development NN cord-344988-09vpehvf 280 8 of of IN cord-344988-09vpehvf 280 9 a a DT cord-344988-09vpehvf 280 10 secondary secondary JJ cord-344988-09vpehvf 280 11 immune immune JJ cord-344988-09vpehvf 280 12 response response NN cord-344988-09vpehvf 280 13 in in IN cord-344988-09vpehvf 280 14 mice mouse NNS cord-344988-09vpehvf 280 15 by by IN cord-344988-09vpehvf 280 16 zinc zinc NN cord-344988-09vpehvf 280 17 deprivation deprivation NN cord-344988-09vpehvf 280 18 : : : cord-344988-09vpehvf 280 19 persistence persistence NN cord-344988-09vpehvf 280 20 of of IN cord-344988-09vpehvf 280 21 effects effect NNS cord-344988-09vpehvf 280 22 Effects effect NNS cord-344988-09vpehvf 280 23 of of IN cord-344988-09vpehvf 280 24 zinc zinc NN cord-344988-09vpehvf 280 25 supplementation supplementation NN cord-344988-09vpehvf 280 26 in in IN cord-344988-09vpehvf 280 27 patients patient NNS cord-344988-09vpehvf 280 28 with with IN cord-344988-09vpehvf 280 29 type type NN cord-344988-09vpehvf 280 30 1 1 CD cord-344988-09vpehvf 280 31 diabetes diabetes NN cord-344988-09vpehvf 281 1 The the DT cord-344988-09vpehvf 281 2 role role NN cord-344988-09vpehvf 281 3 of of IN cord-344988-09vpehvf 281 4 assembly assembly NN cord-344988-09vpehvf 281 5 in in IN cord-344988-09vpehvf 281 6 insulin insulin NN cord-344988-09vpehvf 281 7 's 's POS cord-344988-09vpehvf 281 8 biosynthesis biosynthesis NN cord-344988-09vpehvf 281 9 Zinc zinc NN cord-344988-09vpehvf 281 10 and and CC cord-344988-09vpehvf 281 11 the the DT cord-344988-09vpehvf 281 12 gene gene NN cord-344988-09vpehvf 281 13 Beneficial beneficial JJ cord-344988-09vpehvf 281 14 effects effect NNS cord-344988-09vpehvf 281 15 of of IN cord-344988-09vpehvf 281 16 oral oral JJ cord-344988-09vpehvf 281 17 zinc zinc NN cord-344988-09vpehvf 281 18 supplementation supplementation NN cord-344988-09vpehvf 281 19 on on IN cord-344988-09vpehvf 281 20 the the DT cord-344988-09vpehvf 281 21 immune immune JJ cord-344988-09vpehvf 281 22 response response NN cord-344988-09vpehvf 281 23 of of IN cord-344988-09vpehvf 281 24 old old JJ cord-344988-09vpehvf 281 25 people people NNS cord-344988-09vpehvf 281 26 Plasma plasma NN cord-344988-09vpehvf 281 27 zinc zinc NN cord-344988-09vpehvf 281 28 concentrations concentration NNS cord-344988-09vpehvf 281 29 are be VBP cord-344988-09vpehvf 281 30 depressed depressed JJ cord-344988-09vpehvf 281 31 during during IN cord-344988-09vpehvf 281 32 the the DT cord-344988-09vpehvf 281 33 acute acute JJ cord-344988-09vpehvf 281 34 phase phase NN cord-344988-09vpehvf 281 35 response response NN cord-344988-09vpehvf 281 36 in in IN cord-344988-09vpehvf 281 37 children child NNS cord-344988-09vpehvf 281 38 with with IN cord-344988-09vpehvf 281 39 falciparum falciparum NN cord-344988-09vpehvf 281 40 malaria malaria NNP cord-344988-09vpehvf 281 41 Transcriptional Transcriptional NNP cord-344988-09vpehvf 281 42 regulation regulation NN cord-344988-09vpehvf 281 43 of of IN cord-344988-09vpehvf 281 44 the the DT cord-344988-09vpehvf 281 45 mouse mouse NN cord-344988-09vpehvf 281 46 metallothionein metallothionein NNP cord-344988-09vpehvf 282 1 -I -i DT cord-344988-09vpehvf 282 2 gene gene NN cord-344988-09vpehvf 282 3 by by IN cord-344988-09vpehvf 282 4 heavy heavy JJ cord-344988-09vpehvf 282 5 metals metal NNS cord-344988-09vpehvf 282 6 Bioavailability Bioavailability NNP cord-344988-09vpehvf 282 7 of of IN cord-344988-09vpehvf 282 8 zinc zinc NN cord-344988-09vpehvf 282 9 in in IN cord-344988-09vpehvf 282 10 several several JJ cord-344988-09vpehvf 282 11 sources source NNS cord-344988-09vpehvf 282 12 of of IN cord-344988-09vpehvf 282 13 zinc zinc NN cord-344988-09vpehvf 282 14 oxide oxide NN cord-344988-09vpehvf 282 15 , , , cord-344988-09vpehvf 282 16 zinc zinc NN cord-344988-09vpehvf 282 17 sulfate sulfate NN cord-344988-09vpehvf 282 18 , , , cord-344988-09vpehvf 282 19 and and CC cord-344988-09vpehvf 282 20 zinc zinc NN cord-344988-09vpehvf 282 21 metal metal NN cord-344988-09vpehvf 282 22 Effect effect NN cord-344988-09vpehvf 282 23 of of IN cord-344988-09vpehvf 282 24 oral oral JJ cord-344988-09vpehvf 282 25 zinc zinc NN cord-344988-09vpehvf 282 26 supplementation supplementation NN cord-344988-09vpehvf 282 27 on on IN cord-344988-09vpehvf 282 28 the the DT cord-344988-09vpehvf 282 29 cell cell NN cord-344988-09vpehvf 282 30 mediated mediate VBN cord-344988-09vpehvf 282 31 immunity immunity NN cord-344988-09vpehvf 282 32 in in IN cord-344988-09vpehvf 282 33 lepromatous lepromatous JJ cord-344988-09vpehvf 282 34 leprosy leprosy NN cord-344988-09vpehvf 282 35 Role role NN cord-344988-09vpehvf 282 36 of of IN cord-344988-09vpehvf 282 37 zinc zinc NN cord-344988-09vpehvf 282 38 in in IN cord-344988-09vpehvf 282 39 insulin insulin NN cord-344988-09vpehvf 282 40 biosynthesis biosynthesis NN cord-344988-09vpehvf 282 41 : : : cord-344988-09vpehvf 282 42 some some DT cord-344988-09vpehvf 282 43 possible possible JJ cord-344988-09vpehvf 282 44 zinc zinc NN cord-344988-09vpehvf 282 45 - - HYPH cord-344988-09vpehvf 282 46 insulin insulin NN cord-344988-09vpehvf 282 47 interactions interaction NNS cord-344988-09vpehvf 282 48 in in IN cord-344988-09vpehvf 282 49 the the DT cord-344988-09vpehvf 282 50 pancreatic pancreatic JJ cord-344988-09vpehvf 282 51 B b NN cord-344988-09vpehvf 282 52 - - HYPH cord-344988-09vpehvf 282 53 cell cell NN cord-344988-09vpehvf 282 54 Zinc zinc NN cord-344988-09vpehvf 282 55 in in IN cord-344988-09vpehvf 282 56 developmental developmental JJ cord-344988-09vpehvf 282 57 biology biology NN cord-344988-09vpehvf 282 58 : : : cord-344988-09vpehvf 282 59 the the DT cord-344988-09vpehvf 282 60 role role NN cord-344988-09vpehvf 282 61 of of IN cord-344988-09vpehvf 282 62 metal metal NN cord-344988-09vpehvf 282 63 dependent dependent JJ cord-344988-09vpehvf 282 64 transcription transcription NN cord-344988-09vpehvf 282 65 regulation regulation NN cord-344988-09vpehvf 282 66 Lipid lipid NN cord-344988-09vpehvf 282 67 peroxidation peroxidation NN cord-344988-09vpehvf 282 68 in in IN cord-344988-09vpehvf 282 69 insulin insulin NN cord-344988-09vpehvf 282 70 - - HYPH cord-344988-09vpehvf 282 71 dependent dependent JJ cord-344988-09vpehvf 282 72 diabetic diabetic JJ cord-344988-09vpehvf 282 73 patients patient NNS cord-344988-09vpehvf 282 74 with with IN cord-344988-09vpehvf 282 75 early early JJ cord-344988-09vpehvf 282 76 retina retina JJ cord-344988-09vpehvf 282 77 degenerative degenerative JJ cord-344988-09vpehvf 282 78 lesions lesion NNS cord-344988-09vpehvf 282 79 : : : cord-344988-09vpehvf 282 80 effects effect NNS cord-344988-09vpehvf 282 81 of of IN cord-344988-09vpehvf 282 82 an an DT cord-344988-09vpehvf 282 83 oral oral JJ cord-344988-09vpehvf 282 84 zinc zinc NN cord-344988-09vpehvf 282 85 supplementation supplementation NN cord-344988-09vpehvf 282 86 Trial Trial NNP cord-344988-09vpehvf 282 87 of of IN cord-344988-09vpehvf 282 88 zinc zinc NN cord-344988-09vpehvf 282 89 supplements supplement NNS cord-344988-09vpehvf 282 90 in in IN cord-344988-09vpehvf 282 91 relation relation NN cord-344988-09vpehvf 282 92 to to IN cord-344988-09vpehvf 282 93 pregnancy pregnancy NN cord-344988-09vpehvf 282 94 outcomes outcome NNS cord-344988-09vpehvf 282 95 , , , cord-344988-09vpehvf 282 96 hematologic hematologic JJ cord-344988-09vpehvf 282 97 indicators indicator NNS cord-344988-09vpehvf 282 98 , , , cord-344988-09vpehvf 282 99 and and CC cord-344988-09vpehvf 282 100 T t NN cord-344988-09vpehvf 282 101 cell cell NN cord-344988-09vpehvf 282 102 counts count VBZ cord-344988-09vpehvf 282 103 among among IN cord-344988-09vpehvf 282 104 HIV-1-infected hiv-1-infecte VBN cord-344988-09vpehvf 282 105 women woman NNS cord-344988-09vpehvf 282 106 in in IN cord-344988-09vpehvf 282 107 Tanzania Tanzania NNP cord-344988-09vpehvf 282 108 Zinc Zinc NNP cord-344988-09vpehvf 282 109 and and CC cord-344988-09vpehvf 282 110 the the DT cord-344988-09vpehvf 282 111 risk risk NN cord-344988-09vpehvf 282 112 for for IN cord-344988-09vpehvf 282 113 infectious infectious JJ cord-344988-09vpehvf 282 114 disease disease NN cord-344988-09vpehvf 283 1 An an DT cord-344988-09vpehvf 283 2 essential essential JJ cord-344988-09vpehvf 283 3 role role NN cord-344988-09vpehvf 283 4 for for IN cord-344988-09vpehvf 283 5 interferon interferon NN cord-344988-09vpehvf 283 6 gamma gamma NN cord-344988-09vpehvf 283 7 in in IN cord-344988-09vpehvf 283 8 resistance resistance NN cord-344988-09vpehvf 283 9 to to IN cord-344988-09vpehvf 283 10 Mycobacterium Mycobacterium NNP cord-344988-09vpehvf 283 11 tuberculosis tuberculosis NN cord-344988-09vpehvf 283 12 infection infection NN cord-344988-09vpehvf 283 13 Regeneration regeneration NN cord-344988-09vpehvf 283 14 of of IN cord-344988-09vpehvf 283 15 T t NN cord-344988-09vpehvf 283 16 - - HYPH cord-344988-09vpehvf 283 17 cell cell NN cord-344988-09vpehvf 283 18 helper helper NN cord-344988-09vpehvf 283 19 function function NN cord-344988-09vpehvf 283 20 in in IN cord-344988-09vpehvf 283 21 zinc zinc NN cord-344988-09vpehvf 283 22 - - HYPH cord-344988-09vpehvf 283 23 deficient deficient JJ cord-344988-09vpehvf 283 24 adult adult NN cord-344988-09vpehvf 283 25 mice mouse NNS cord-344988-09vpehvf 283 26 Interrelationships interrelationship NNS cord-344988-09vpehvf 283 27 between between IN cord-344988-09vpehvf 283 28 zinc zinc NN cord-344988-09vpehvf 283 29 and and CC cord-344988-09vpehvf 283 30 immune immune JJ cord-344988-09vpehvf 283 31 function function NN cord-344988-09vpehvf 284 1 Zinc zinc NN cord-344988-09vpehvf 284 2 deficiency deficiency NN cord-344988-09vpehvf 284 3 and and CC cord-344988-09vpehvf 284 4 the the DT cord-344988-09vpehvf 284 5 immune immune JJ cord-344988-09vpehvf 284 6 function function NN cord-344988-09vpehvf 284 7 Reprogramming reprogramme VBG cord-344988-09vpehvf 284 8 of of IN cord-344988-09vpehvf 284 9 the the DT cord-344988-09vpehvf 284 10 immune immune JJ cord-344988-09vpehvf 284 11 system system NN cord-344988-09vpehvf 284 12 during during IN cord-344988-09vpehvf 285 1 zinc zinc NN cord-344988-09vpehvf 285 2 deficiency deficiency NN cord-344988-09vpehvf 285 3 Zinc Zinc NNP cord-344988-09vpehvf 285 4 suppresses suppress VBZ cord-344988-09vpehvf 285 5 apoptosis apoptosis NN cord-344988-09vpehvf 285 6 of of IN cord-344988-09vpehvf 285 7 U937 U937 NNP cord-344988-09vpehvf 285 8 cells cell NNS cord-344988-09vpehvf 285 9 induced induce VBN cord-344988-09vpehvf 285 10 by by IN cord-344988-09vpehvf 285 11 hydrogen hydrogen NN cord-344988-09vpehvf 285 12 peroxide peroxide NN cord-344988-09vpehvf 285 13 through through IN cord-344988-09vpehvf 285 14 an an DT cord-344988-09vpehvf 285 15 increase increase NN cord-344988-09vpehvf 285 16 of of IN cord-344988-09vpehvf 285 17 Bcl-2 Bcl-2 NNP cord-344988-09vpehvf 285 18 / / SYM cord-344988-09vpehvf 285 19 Bax Bax NNP cord-344988-09vpehvf 285 20 ratio ratio NN cord-344988-09vpehvf 285 21 Treatment Treatment NNP cord-344988-09vpehvf 285 22 of of IN cord-344988-09vpehvf 285 23 acrodermatitis acrodermatitis NNP cord-344988-09vpehvf 285 24 enteropathica enteropathica NNP cord-344988-09vpehvf 285 25 with with IN cord-344988-09vpehvf 285 26 zinc zinc NN cord-344988-09vpehvf 285 27 sulphate sulphate NN cord-344988-09vpehvf 285 28 Effect effect NN cord-344988-09vpehvf 285 29 of of IN cord-344988-09vpehvf 285 30 severe severe JJ cord-344988-09vpehvf 285 31 zinc zinc NN cord-344988-09vpehvf 285 32 deficiency deficiency NN cord-344988-09vpehvf 285 33 on on IN cord-344988-09vpehvf 285 34 activity activity NN cord-344988-09vpehvf 285 35 of of IN cord-344988-09vpehvf 285 36 intestinal intestinal JJ cord-344988-09vpehvf 285 37 disaccharidases disaccharidase NNS cord-344988-09vpehvf 285 38 and and CC cord-344988-09vpehvf 285 39 3-hydroxy-3-methy 3-hydroxy-3-methy CD cord-344988-09vpehvf 285 40 - - HYPH cord-344988-09vpehvf 285 41 glutaryl glutaryl NNP cord-344988-09vpehvf 285 42 coenzyme coenzyme VBZ cord-344988-09vpehvf 285 43 A a DT cord-344988-09vpehvf 285 44 reductase reductase NN cord-344988-09vpehvf 285 45 in in IN cord-344988-09vpehvf 285 46 the the DT cord-344988-09vpehvf 285 47 rat rat NN cord-344988-09vpehvf 286 1 In in IN cord-344988-09vpehvf 286 2 vitro vitro FW cord-344988-09vpehvf 286 3 activity activity NN cord-344988-09vpehvf 286 4 of of IN cord-344988-09vpehvf 286 5 zinc zinc NN cord-344988-09vpehvf 286 6 salts salt NNS cord-344988-09vpehvf 286 7 against against IN cord-344988-09vpehvf 286 8 human human JJ cord-344988-09vpehvf 286 9 rhinoviruses rhinovirus NNS cord-344988-09vpehvf 286 10 Serum Serum NNP cord-344988-09vpehvf 286 11 zinc zinc NN cord-344988-09vpehvf 286 12 / / SYM cord-344988-09vpehvf 286 13 copper copper NN cord-344988-09vpehvf 286 14 ratio ratio NN cord-344988-09vpehvf 286 15 in in IN cord-344988-09vpehvf 286 16 subtypes subtype NNS cord-344988-09vpehvf 286 17 of of IN cord-344988-09vpehvf 286 18 leprosy leprosy NN cord-344988-09vpehvf 286 19 and and CC cord-344988-09vpehvf 286 20 effect effect NN cord-344988-09vpehvf 286 21 of of IN cord-344988-09vpehvf 286 22 oral oral JJ cord-344988-09vpehvf 286 23 zinc zinc NN cord-344988-09vpehvf 286 24 therapy therapy NN cord-344988-09vpehvf 286 25 on on IN cord-344988-09vpehvf 286 26 reactional reactional JJ cord-344988-09vpehvf 286 27 states state NNS cord-344988-09vpehvf 286 28 Transport Transport NNP cord-344988-09vpehvf 286 29 of of IN cord-344988-09vpehvf 286 30 electrolytes electrolyte NNS cord-344988-09vpehvf 286 31 , , , cord-344988-09vpehvf 286 32 water water NN cord-344988-09vpehvf 286 33 , , , cord-344988-09vpehvf 286 34 and and CC cord-344988-09vpehvf 286 35 glucose glucose NN cord-344988-09vpehvf 286 36 in in IN cord-344988-09vpehvf 286 37 zinc zinc NN cord-344988-09vpehvf 286 38 deficiency deficiency NN cord-344988-09vpehvf 286 39 Kinetic kinetic JJ cord-344988-09vpehvf 286 40 aspects aspect NNS cord-344988-09vpehvf 286 41 of of IN cord-344988-09vpehvf 286 42 compartmental compartmental JJ cord-344988-09vpehvf 286 43 storage storage NN cord-344988-09vpehvf 286 44 and and CC cord-344988-09vpehvf 286 45 secretion secretion NN cord-344988-09vpehvf 286 46 of of IN cord-344988-09vpehvf 286 47 insulin insulin NN cord-344988-09vpehvf 286 48 and and CC cord-344988-09vpehvf 286 49 zinc zinc NN cord-344988-09vpehvf 286 50 A a DT cord-344988-09vpehvf 286 51 randomised randomised JJ cord-344988-09vpehvf 286 52 controlled control VBN cord-344988-09vpehvf 286 53 trial trial NN cord-344988-09vpehvf 286 54 of of IN cord-344988-09vpehvf 286 55 oral oral JJ cord-344988-09vpehvf 286 56 zinc zinc NN cord-344988-09vpehvf 286 57 on on IN cord-344988-09vpehvf 286 58 the the DT cord-344988-09vpehvf 286 59 immune immune JJ cord-344988-09vpehvf 286 60 response response NN cord-344988-09vpehvf 286 61 to to IN cord-344988-09vpehvf 286 62 tuberculosis tuberculosis NN cord-344988-09vpehvf 286 63 in in IN cord-344988-09vpehvf 286 64 HIV HIV NNP cord-344988-09vpehvf 286 65 - - HYPH cord-344988-09vpehvf 286 66 infected infect VBN cord-344988-09vpehvf 286 67 patients patient NNS cord-344988-09vpehvf 287 1 Zinc zinc NN cord-344988-09vpehvf 287 2 as as IN cord-344988-09vpehvf 287 3 a a DT cord-344988-09vpehvf 287 4 second second JJ cord-344988-09vpehvf 287 5 messenger messenger NN cord-344988-09vpehvf 287 6 of of IN cord-344988-09vpehvf 287 7 mitogenic mitogenic NNP cord-344988-09vpehvf 287 8 induction induction NNP cord-344988-09vpehvf 287 9 . . . cord-344988-09vpehvf 288 1 Effects effect NNS cord-344988-09vpehvf 288 2 on on IN cord-344988-09vpehvf 288 3 diadenosine diadenosine NN cord-344988-09vpehvf 288 4 tetraphosphate tetraphosphate NN cord-344988-09vpehvf 288 5 ( ( -LRB- cord-344988-09vpehvf 288 6 Ap4A Ap4A NNP cord-344988-09vpehvf 288 7 ) ) -RRB- cord-344988-09vpehvf 288 8 and and CC cord-344988-09vpehvf 288 9 DNA dna NN cord-344988-09vpehvf 288 10 synthesis synthesis NN cord-344988-09vpehvf 288 11 Flow flow NN cord-344988-09vpehvf 288 12 cytometric cytometric NN cord-344988-09vpehvf 288 13 measurement measurement NN cord-344988-09vpehvf 288 14 of of IN cord-344988-09vpehvf 288 15 labile labile JJ cord-344988-09vpehvf 288 16 zinc zinc NN cord-344988-09vpehvf 288 17 in in IN cord-344988-09vpehvf 288 18 peripheral peripheral JJ cord-344988-09vpehvf 288 19 blood blood NN cord-344988-09vpehvf 288 20 mononuclear mononuclear NN cord-344988-09vpehvf 288 21 cells cell NNS cord-344988-09vpehvf 288 22 Correlation correlation NN cord-344988-09vpehvf 288 23 between between IN cord-344988-09vpehvf 288 24 zinc zinc NN cord-344988-09vpehvf 288 25 status status NN cord-344988-09vpehvf 288 26 and and CC cord-344988-09vpehvf 288 27 immune immune JJ cord-344988-09vpehvf 288 28 function function NN cord-344988-09vpehvf 288 29 in in IN cord-344988-09vpehvf 288 30 the the DT cord-344988-09vpehvf 288 31 elderly elderly JJ cord-344988-09vpehvf 288 32 Signal Signal NNP cord-344988-09vpehvf 288 33 transduction transduction NN cord-344988-09vpehvf 288 34 in in IN cord-344988-09vpehvf 288 35 monocytes monocyte NNS cord-344988-09vpehvf 288 36 : : : cord-344988-09vpehvf 288 37 the the DT cord-344988-09vpehvf 288 38 role role NN cord-344988-09vpehvf 288 39 of of IN cord-344988-09vpehvf 288 40 zinc zinc NN cord-344988-09vpehvf 288 41 ions ion NNS cord-344988-09vpehvf 288 42 Imbalance imbalance NN cord-344988-09vpehvf 288 43 between between IN cord-344988-09vpehvf 288 44 pro pro JJ cord-344988-09vpehvf 288 45 - - JJ cord-344988-09vpehvf 288 46 oxidant oxidant JJ cord-344988-09vpehvf 288 47 and and CC cord-344988-09vpehvf 288 48 pro pro JJ cord-344988-09vpehvf 288 49 - - JJ cord-344988-09vpehvf 288 50 antioxidant antioxidant JJ cord-344988-09vpehvf 288 51 functions function NNS cord-344988-09vpehvf 288 52 of of IN cord-344988-09vpehvf 288 53 zinc zinc NN cord-344988-09vpehvf 288 54 in in IN cord-344988-09vpehvf 288 55 disease disease NN cord-344988-09vpehvf 288 56 Inhibition Inhibition NNP cord-344988-09vpehvf 288 57 of of IN cord-344988-09vpehvf 288 58 HIV-1 HIV-1 NNP cord-344988-09vpehvf 288 59 infection infection NN cord-344988-09vpehvf 288 60 by by IN cord-344988-09vpehvf 288 61 zinc zinc NN cord-344988-09vpehvf 288 62 group group NN cord-344988-09vpehvf 288 63 metal metal NN cord-344988-09vpehvf 288 64 compounds compound NNS cord-344988-09vpehvf 288 65 Effect Effect NNP cord-344988-09vpehvf 288 66 of of IN cord-344988-09vpehvf 288 67 intragastric intragastric JJ cord-344988-09vpehvf 288 68 pH ph NN cord-344988-09vpehvf 288 69 on on IN cord-344988-09vpehvf 288 70 the the DT cord-344988-09vpehvf 288 71 absorption absorption NN cord-344988-09vpehvf 288 72 of of IN cord-344988-09vpehvf 288 73 oral oral JJ cord-344988-09vpehvf 288 74 zinc zinc NN cord-344988-09vpehvf 288 75 acetate acetate NN cord-344988-09vpehvf 288 76 and and CC cord-344988-09vpehvf 288 77 zinc zinc NN cord-344988-09vpehvf 288 78 oxide oxide NN cord-344988-09vpehvf 288 79 in in IN cord-344988-09vpehvf 288 80 young young JJ cord-344988-09vpehvf 288 81 healthy healthy JJ cord-344988-09vpehvf 288 82 volunteers volunteer NNS cord-344988-09vpehvf 288 83 Zinc Zinc NNP cord-344988-09vpehvf 288 84 aspartate aspartate NN cord-344988-09vpehvf 288 85 in in IN cord-344988-09vpehvf 288 86 vivo vivo NN cord-344988-09vpehvf 288 87 and and CC cord-344988-09vpehvf 288 88 in in IN cord-344988-09vpehvf 288 89 vitro vitro FW cord-344988-09vpehvf 288 90 modulation modulation NN cord-344988-09vpehvf 288 91 of of IN cord-344988-09vpehvf 288 92 reactive reactive JJ cord-344988-09vpehvf 288 93 oxygen oxygen NN cord-344988-09vpehvf 288 94 species specie NNS cord-344988-09vpehvf 288 95 production production NN cord-344988-09vpehvf 288 96 by by IN cord-344988-09vpehvf 288 97 human human JJ cord-344988-09vpehvf 288 98 neutrophils neutrophil NNS cord-344988-09vpehvf 288 99 and and CC cord-344988-09vpehvf 288 100 monocytes monocyte VBZ cord-344988-09vpehvf 288 101 Zinc zinc NN cord-344988-09vpehvf 288 102 in in IN cord-344988-09vpehvf 288 103 the the DT cord-344988-09vpehvf 288 104 treatment treatment NN cord-344988-09vpehvf 288 105 of of IN cord-344988-09vpehvf 288 106 acute acute JJ cord-344988-09vpehvf 288 107 diarrhea diarrhea NN cord-344988-09vpehvf 288 108 : : : cord-344988-09vpehvf 288 109 current current JJ cord-344988-09vpehvf 288 110 status status NN cord-344988-09vpehvf 288 111 and and CC cord-344988-09vpehvf 288 112 assessment assessment NN cord-344988-09vpehvf 288 113 Efficacy Efficacy NNP cord-344988-09vpehvf 288 114 of of IN cord-344988-09vpehvf 288 115 zinc zinc NN cord-344988-09vpehvf 288 116 against against IN cord-344988-09vpehvf 288 117 common common JJ cord-344988-09vpehvf 288 118 cold cold JJ cord-344988-09vpehvf 288 119 viruses virus NNS cord-344988-09vpehvf 288 120 : : : cord-344988-09vpehvf 288 121 an an DT cord-344988-09vpehvf 288 122 overview overview NN cord-344988-09vpehvf 288 123 Zinc zinc NN cord-344988-09vpehvf 288 124 - - HYPH cord-344988-09vpehvf 288 125 altered alter VBN cord-344988-09vpehvf 288 126 immune immune JJ cord-344988-09vpehvf 288 127 function function NN cord-344988-09vpehvf 288 128 Zinc zinc NN cord-344988-09vpehvf 288 129 and and CC cord-344988-09vpehvf 288 130 the the DT cord-344988-09vpehvf 288 131 common common JJ cord-344988-09vpehvf 288 132 cold cold NN cord-344988-09vpehvf 288 133 : : : cord-344988-09vpehvf 288 134 a a DT cord-344988-09vpehvf 288 135 meta meta JJ cord-344988-09vpehvf 288 136 - - HYPH cord-344988-09vpehvf 288 137 analysis analysis NN cord-344988-09vpehvf 288 138 revisited revisit VBN cord-344988-09vpehvf 288 139 A a DT cord-344988-09vpehvf 288 140 meta meta NNP cord-344988-09vpehvf 288 141 -- -- : cord-344988-09vpehvf 288 142 analysis analysis NN cord-344988-09vpehvf 288 143 of of IN cord-344988-09vpehvf 288 144 zinc zinc NN cord-344988-09vpehvf 288 145 salts salt NNS cord-344988-09vpehvf 288 146 lozenges lozenge NNS cord-344988-09vpehvf 288 147 and and CC cord-344988-09vpehvf 288 148 the the DT cord-344988-09vpehvf 288 149 common common JJ cord-344988-09vpehvf 288 150 cold cold JJ cord-344988-09vpehvf 288 151 Intestinal intestinal JJ cord-344988-09vpehvf 288 152 and and CC cord-344988-09vpehvf 288 153 systemic systemic JJ cord-344988-09vpehvf 288 154 immune immune JJ cord-344988-09vpehvf 288 155 responses response NNS cord-344988-09vpehvf 288 156 to to IN cord-344988-09vpehvf 288 157 an an DT cord-344988-09vpehvf 288 158 oral oral JJ cord-344988-09vpehvf 288 159 cholera cholera NN cord-344988-09vpehvf 288 160 toxoid toxoid NN cord-344988-09vpehvf 288 161 B B NNP cord-344988-09vpehvf 288 162 subunit subunit NN cord-344988-09vpehvf 288 163 whole whole JJ cord-344988-09vpehvf 288 164 - - HYPH cord-344988-09vpehvf 288 165 cell cell NN cord-344988-09vpehvf 288 166 vaccine vaccine NN cord-344988-09vpehvf 288 167 administered administer VBN cord-344988-09vpehvf 288 168 during during IN cord-344988-09vpehvf 288 169 zinc zinc NN cord-344988-09vpehvf 288 170 supplementation supplementation NN cord-344988-09vpehvf 289 1 A a DT cord-344988-09vpehvf 289 2 double double JJ cord-344988-09vpehvf 289 3 - - HYPH cord-344988-09vpehvf 289 4 blind blind JJ cord-344988-09vpehvf 289 5 , , , cord-344988-09vpehvf 289 6 placebo placebo NN cord-344988-09vpehvf 289 7 - - HYPH cord-344988-09vpehvf 289 8 controlled control VBN cord-344988-09vpehvf 289 9 study study NN cord-344988-09vpehvf 289 10 of of IN cord-344988-09vpehvf 289 11 vitamin vitamin NN cord-344988-09vpehvf 289 12 A a NN cord-344988-09vpehvf 289 13 and and CC cord-344988-09vpehvf 289 14 zinc zinc NN cord-344988-09vpehvf 289 15 supplementation supplementation NN cord-344988-09vpehvf 289 16 in in IN cord-344988-09vpehvf 289 17 persons person NNS cord-344988-09vpehvf 289 18 with with IN cord-344988-09vpehvf 289 19 tuberculosis tuberculosis NN cord-344988-09vpehvf 289 20 in in IN cord-344988-09vpehvf 289 21 Indonesia Indonesia NNP cord-344988-09vpehvf 289 22 : : : cord-344988-09vpehvf 289 23 effects effect NNS cord-344988-09vpehvf 289 24 on on IN cord-344988-09vpehvf 289 25 clinical clinical JJ cord-344988-09vpehvf 289 26 response response NN cord-344988-09vpehvf 289 27 and and CC cord-344988-09vpehvf 289 28 nutritional nutritional JJ cord-344988-09vpehvf 289 29 status status NN cord-344988-09vpehvf 289 30 Polaprezinc Polaprezinc NNP cord-344988-09vpehvf 289 31 , , , cord-344988-09vpehvf 289 32 a a DT cord-344988-09vpehvf 289 33 mucosal mucosal JJ cord-344988-09vpehvf 289 34 protective protective JJ cord-344988-09vpehvf 289 35 agent agent NN cord-344988-09vpehvf 289 36 , , , cord-344988-09vpehvf 289 37 in in IN cord-344988-09vpehvf 289 38 combination combination NN cord-344988-09vpehvf 289 39 with with IN cord-344988-09vpehvf 289 40 lansoprazole lansoprazole NN cord-344988-09vpehvf 289 41 , , , cord-344988-09vpehvf 289 42 amoxycillin amoxycillin JJ cord-344988-09vpehvf 289 43 and and CC cord-344988-09vpehvf 289 44 clarithromycin clarithromycin NNS cord-344988-09vpehvf 289 45 increases increase VBZ cord-344988-09vpehvf 289 46 the the DT cord-344988-09vpehvf 289 47 cure cure NN cord-344988-09vpehvf 289 48 rate rate NN cord-344988-09vpehvf 289 49 of of IN cord-344988-09vpehvf 289 50 Helicobacter Helicobacter NNP cord-344988-09vpehvf 289 51 pylori pylori NN cord-344988-09vpehvf 289 52 infection infection NN cord-344988-09vpehvf 290 1 Copper copper NN cord-344988-09vpehvf 290 2 and and CC cord-344988-09vpehvf 290 3 zinc zinc NN cord-344988-09vpehvf 290 4 inhibit inhibit VBP cord-344988-09vpehvf 290 5 the the DT cord-344988-09vpehvf 290 6 metabolism metabolism NN cord-344988-09vpehvf 290 7 of of IN cord-344988-09vpehvf 290 8 prostaglandin prostaglandin NN cord-344988-09vpehvf 290 9 by by IN cord-344988-09vpehvf 290 10 the the DT cord-344988-09vpehvf 290 11 human human JJ cord-344988-09vpehvf 290 12 uterus uterus NN cord-344988-09vpehvf 291 1 The the DT cord-344988-09vpehvf 291 2 effect effect NN cord-344988-09vpehvf 291 3 of of IN cord-344988-09vpehvf 291 4 zinc zinc NN cord-344988-09vpehvf 291 5 supplementation supplementation NN cord-344988-09vpehvf 291 6 on on IN cord-344988-09vpehvf 291 7 the the DT cord-344988-09vpehvf 291 8 treatment treatment NN cord-344988-09vpehvf 291 9 of of IN cord-344988-09vpehvf 291 10 chronic chronic JJ cord-344988-09vpehvf 291 11 hepatitis hepatitis NN cord-344988-09vpehvf 291 12 C c NN cord-344988-09vpehvf 291 13 patients patient NNS cord-344988-09vpehvf 291 14 with with IN cord-344988-09vpehvf 291 15 interferon interferon NN cord-344988-09vpehvf 291 16 and and CC cord-344988-09vpehvf 291 17 ribavirin ribavirin JJ cord-344988-09vpehvf 291 18 Inhibition inhibition NN cord-344988-09vpehvf 291 19 by by IN cord-344988-09vpehvf 291 20 zinc zinc NN cord-344988-09vpehvf 291 21 of of IN cord-344988-09vpehvf 291 22 rhinovirus rhinovirus NN cord-344988-09vpehvf 291 23 protein protein NN cord-344988-09vpehvf 291 24 cleavage cleavage NN cord-344988-09vpehvf 291 25 : : : cord-344988-09vpehvf 291 26 interaction interaction NN cord-344988-09vpehvf 291 27 of of IN cord-344988-09vpehvf 291 28 zinc zinc NN cord-344988-09vpehvf 291 29 with with IN cord-344988-09vpehvf 291 30 capsid capsid NN cord-344988-09vpehvf 291 31 polypeptides polypeptide NNS cord-344988-09vpehvf 292 1 Zinc zinc NN cord-344988-09vpehvf 292 2 ions ion NNS cord-344988-09vpehvf 292 3 inhibit inhibit VBP cord-344988-09vpehvf 292 4 replication replication NN cord-344988-09vpehvf 292 5 of of IN cord-344988-09vpehvf 292 6 rhinoviruses rhinovirus NNS cord-344988-09vpehvf 293 1 The the DT cord-344988-09vpehvf 293 2 impaired impaired JJ cord-344988-09vpehvf 293 3 immune immune JJ cord-344988-09vpehvf 293 4 response response NN cord-344988-09vpehvf 293 5 to to IN cord-344988-09vpehvf 293 6 diphtheria diphtheria NN cord-344988-09vpehvf 293 7 vaccination vaccination NN cord-344988-09vpehvf 293 8 in in IN cord-344988-09vpehvf 293 9 elderly elderly JJ cord-344988-09vpehvf 293 10 chronic chronic JJ cord-344988-09vpehvf 293 11 hemodialysis hemodialysis NN cord-344988-09vpehvf 293 12 patients patient NNS cord-344988-09vpehvf 293 13 is be VBZ cord-344988-09vpehvf 293 14 related relate VBN cord-344988-09vpehvf 293 15 to to IN cord-344988-09vpehvf 293 16 zinc zinc NN cord-344988-09vpehvf 293 17 deficiency deficiency NN cord-344988-09vpehvf 294 1 Transgenic transgenic JJ cord-344988-09vpehvf 294 2 copper copper NN cord-344988-09vpehvf 294 3 / / SYM cord-344988-09vpehvf 294 4 zinc zinc NN cord-344988-09vpehvf 294 5 superoxide superoxide NN cord-344988-09vpehvf 294 6 dismutase dismutase NN cord-344988-09vpehvf 294 7 modulates modulate VBZ cord-344988-09vpehvf 294 8 susceptibility susceptibility NN cord-344988-09vpehvf 294 9 to to TO cord-344988-09vpehvf 294 10 type type VB cord-344988-09vpehvf 294 11 1 1 CD cord-344988-09vpehvf 294 12 diabetes diabetes NN cord-344988-09vpehvf 295 1 The the DT cord-344988-09vpehvf 295 2 mechanism mechanism NN cord-344988-09vpehvf 295 3 of of IN cord-344988-09vpehvf 295 4 the the DT cord-344988-09vpehvf 295 5 antiherpetic antiherpetic JJ cord-344988-09vpehvf 295 6 activity activity NN cord-344988-09vpehvf 295 7 of of IN cord-344988-09vpehvf 295 8 zinc zinc NN cord-344988-09vpehvf 295 9 sulphate sulphate NN cord-344988-09vpehvf 295 10 The the DT cord-344988-09vpehvf 295 11 prophylactic prophylactic JJ cord-344988-09vpehvf 295 12 and and CC cord-344988-09vpehvf 295 13 therapeutic therapeutic JJ cord-344988-09vpehvf 295 14 effectiveness effectiveness NN cord-344988-09vpehvf 295 15 of of IN cord-344988-09vpehvf 295 16 zinc zinc NN cord-344988-09vpehvf 295 17 sulphate sulphate NN cord-344988-09vpehvf 295 18 on on IN cord-344988-09vpehvf 295 19 common common JJ cord-344988-09vpehvf 295 20 cold cold NN cord-344988-09vpehvf 295 21 in in IN cord-344988-09vpehvf 295 22 children child NNS cord-344988-09vpehvf 295 23 Identification Identification NNP cord-344988-09vpehvf 295 24 of of IN cord-344988-09vpehvf 295 25 SLC39A4 SLC39A4 NNP cord-344988-09vpehvf 295 26 , , , cord-344988-09vpehvf 295 27 a a DT cord-344988-09vpehvf 295 28 gene gene NN cord-344988-09vpehvf 295 29 involved involve VBN cord-344988-09vpehvf 295 30 in in IN cord-344988-09vpehvf 295 31 acrodermatitis acrodermatitis NNP cord-344988-09vpehvf 295 32 enteropathica enteropathica NNP cord-344988-09vpehvf 296 1 Interleukin-6 Interleukin-6 NNP cord-344988-09vpehvf 296 2 regulates regulate VBZ cord-344988-09vpehvf 296 3 the the DT cord-344988-09vpehvf 296 4 zinc zinc NN cord-344988-09vpehvf 296 5 transporter transporter NN cord-344988-09vpehvf 296 6 Zip14 Zip14 NNP cord-344988-09vpehvf 296 7 in in IN cord-344988-09vpehvf 296 8 liver liver NN cord-344988-09vpehvf 296 9 and and CC cord-344988-09vpehvf 296 10 contributes contribute VBZ cord-344988-09vpehvf 296 11 to to IN cord-344988-09vpehvf 296 12 the the DT cord-344988-09vpehvf 296 13 hypozincemia hypozincemia NN cord-344988-09vpehvf 296 14 of of IN cord-344988-09vpehvf 296 15 the the DT cord-344988-09vpehvf 296 16 acute acute JJ cord-344988-09vpehvf 296 17 -- -- : cord-344988-09vpehvf 296 18 phase phase NN cord-344988-09vpehvf 296 19 response response NN cord-344988-09vpehvf 296 20 Absorption absorption NN cord-344988-09vpehvf 296 21 of of IN cord-344988-09vpehvf 296 22 zinc zinc NN cord-344988-09vpehvf 296 23 in in IN cord-344988-09vpehvf 296 24 acrodermatifis acrodermatifis NNP cord-344988-09vpehvf 296 25 enteropathica enteropathica JJ cord-344988-09vpehvf 296 26 Dietary dietary JJ cord-344988-09vpehvf 296 27 factors factor NNS cord-344988-09vpehvf 296 28 influencing influence VBG cord-344988-09vpehvf 296 29 zinc zinc NN cord-344988-09vpehvf 296 30 absorption absorption NN cord-344988-09vpehvf 296 31 The the DT cord-344988-09vpehvf 296 32 role role NN cord-344988-09vpehvf 296 33 of of IN cord-344988-09vpehvf 296 34 zinc zinc NN cord-344988-09vpehvf 296 35 in in IN cord-344988-09vpehvf 296 36 growth growth NN cord-344988-09vpehvf 296 37 and and CC cord-344988-09vpehvf 296 38 cell cell NN cord-344988-09vpehvf 296 39 proliferation proliferation NN cord-344988-09vpehvf 296 40 Oral oral JJ cord-344988-09vpehvf 296 41 zinc zinc NN cord-344988-09vpehvf 296 42 therapy therapy NN cord-344988-09vpehvf 296 43 in in IN cord-344988-09vpehvf 296 44 recurrent recurrent JJ cord-344988-09vpehvf 296 45 erythema erythema NN cord-344988-09vpehvf 296 46 nodosum nodosum NNP cord-344988-09vpehvf 296 47 leprosum leprosum NNP cord-344988-09vpehvf 296 48 : : : cord-344988-09vpehvf 296 49 a a DT cord-344988-09vpehvf 296 50 clinical clinical JJ cord-344988-09vpehvf 296 51 study study NN cord-344988-09vpehvf 296 52 Randomized randomized JJ cord-344988-09vpehvf 296 53 , , , cord-344988-09vpehvf 296 54 double double JJ cord-344988-09vpehvf 296 55 - - HYPH cord-344988-09vpehvf 296 56 blind blind JJ cord-344988-09vpehvf 296 57 , , , cord-344988-09vpehvf 296 58 placebo placebo NN cord-344988-09vpehvf 296 59 - - HYPH cord-344988-09vpehvf 296 60 controlled control VBN cord-344988-09vpehvf 296 61 clinical clinical JJ cord-344988-09vpehvf 296 62 trial trial NN cord-344988-09vpehvf 296 63 of of IN cord-344988-09vpehvf 296 64 the the DT cord-344988-09vpehvf 296 65 efficacy efficacy NN cord-344988-09vpehvf 296 66 of of IN cord-344988-09vpehvf 296 67 treatment treatment NN cord-344988-09vpehvf 296 68 with with IN cord-344988-09vpehvf 296 69 zinc zinc NN cord-344988-09vpehvf 296 70 or or CC cord-344988-09vpehvf 296 71 vitamin vitamin NN cord-344988-09vpehvf 296 72 A a NN cord-344988-09vpehvf 296 73 in in IN cord-344988-09vpehvf 296 74 infants infant NNS cord-344988-09vpehvf 296 75 and and CC cord-344988-09vpehvf 296 76 young young JJ cord-344988-09vpehvf 296 77 children child NNS cord-344988-09vpehvf 296 78 with with IN cord-344988-09vpehvf 296 79 severe severe JJ cord-344988-09vpehvf 296 80 acute acute JJ cord-344988-09vpehvf 296 81 lower low JJR cord-344988-09vpehvf 296 82 respiratory respiratory JJ cord-344988-09vpehvf 296 83 infection infection NN cord-344988-09vpehvf 296 84 Metallothionein metallothionein NN cord-344988-09vpehvf 296 85 and and CC cord-344988-09vpehvf 296 86 tissue tissue NN cord-344988-09vpehvf 296 87 damage damage NN cord-344988-09vpehvf 296 88 Zinc zinc NN cord-344988-09vpehvf 296 89 coordination coordination NN cord-344988-09vpehvf 296 90 environments environment NNS cord-344988-09vpehvf 296 91 in in IN cord-344988-09vpehvf 296 92 proteins protein NNS cord-344988-09vpehvf 296 93 as as IN cord-344988-09vpehvf 296 94 redox redox JJ cord-344988-09vpehvf 296 95 sensors sensor NNS cord-344988-09vpehvf 296 96 and and CC cord-344988-09vpehvf 296 97 signal signal NN cord-344988-09vpehvf 296 98 transducers transducer NNS cord-344988-09vpehvf 296 99 Zinc zinc NN cord-344988-09vpehvf 296 100 requirements requirement NNS cord-344988-09vpehvf 296 101 and and CC cord-344988-09vpehvf 296 102 the the DT cord-344988-09vpehvf 296 103 risks risk NNS cord-344988-09vpehvf 296 104 and and CC cord-344988-09vpehvf 296 105 benefits benefit NNS cord-344988-09vpehvf 296 106 of of IN cord-344988-09vpehvf 296 107 zinc zinc NN cord-344988-09vpehvf 296 108 supplementation supplementation NN cord-344988-09vpehvf 296 109 Oral oral JJ cord-344988-09vpehvf 296 110 zinc zinc NN cord-344988-09vpehvf 296 111 in in IN cord-344988-09vpehvf 296 112 recurrent recurrent JJ cord-344988-09vpehvf 296 113 Erythema erythema NN cord-344988-09vpehvf 296 114 Nodosum Nodosum NNP cord-344988-09vpehvf 296 115 Leprosum Leprosum NNP cord-344988-09vpehvf 296 116 reaction reaction NN cord-344988-09vpehvf 296 117 Oral oral JJ cord-344988-09vpehvf 296 118 zinc zinc NN cord-344988-09vpehvf 296 119 as as IN cord-344988-09vpehvf 296 120 an an DT cord-344988-09vpehvf 296 121 adjunct adjunct NN cord-344988-09vpehvf 296 122 to to IN cord-344988-09vpehvf 296 123 dapsone dapsone NN cord-344988-09vpehvf 296 124 in in IN cord-344988-09vpehvf 296 125 lepromatous lepromatous JJ cord-344988-09vpehvf 296 126 leprosy leprosy NN cord-344988-09vpehvf 296 127 Zinc Zinc NNP cord-344988-09vpehvf 296 128 sulphate sulphate NN cord-344988-09vpehvf 296 129 in in IN cord-344988-09vpehvf 296 130 rheumatoid rheumatoid NN cord-344988-09vpehvf 296 131 arthritis arthritis NN cord-344988-09vpehvf 296 132 Characterization characterization NN cord-344988-09vpehvf 296 133 of of IN cord-344988-09vpehvf 296 134 caspase caspase NN cord-344988-09vpehvf 296 135 processing processing NN cord-344988-09vpehvf 296 136 and and CC cord-344988-09vpehvf 296 137 activation activation NN cord-344988-09vpehvf 296 138 in in IN cord-344988-09vpehvf 296 139 HL-60 HL-60 NNP cord-344988-09vpehvf 296 140 cell cell NN cord-344988-09vpehvf 296 141 cytosol cytosol NN cord-344988-09vpehvf 296 142 under under IN cord-344988-09vpehvf 296 143 cell cell NN cord-344988-09vpehvf 296 144 - - HYPH cord-344988-09vpehvf 296 145 free free JJ cord-344988-09vpehvf 296 146 conditions condition NNS cord-344988-09vpehvf 296 147 . . . cord-344988-09vpehvf 297 1 Nucleotide nucleotide JJ cord-344988-09vpehvf 297 2 requirement requirement NN cord-344988-09vpehvf 297 3 and and CC cord-344988-09vpehvf 297 4 inhibitor inhibitor NN cord-344988-09vpehvf 297 5 profile profile NN cord-344988-09vpehvf 297 6 Serum serum NN cord-344988-09vpehvf 297 7 zinc zinc NN cord-344988-09vpehvf 297 8 and and CC cord-344988-09vpehvf 297 9 pneumonia pneumonia NN cord-344988-09vpehvf 297 10 in in IN cord-344988-09vpehvf 297 11 nursing nursing NN cord-344988-09vpehvf 297 12 home home NN cord-344988-09vpehvf 297 13 elderly elderly JJ cord-344988-09vpehvf 297 14 Bioverfügbarkeit Bioverfügbarkeit NNP cord-344988-09vpehvf 297 15 von von NNP cord-344988-09vpehvf 297 16 Zink Zink NNP cord-344988-09vpehvf 297 17 - - HYPH cord-344988-09vpehvf 297 18 Präparaten Präparaten NNP cord-344988-09vpehvf 297 19 Benefit Benefit NNP cord-344988-09vpehvf 297 20 of of IN cord-344988-09vpehvf 297 21 oral oral JJ cord-344988-09vpehvf 297 22 zinc zinc NN cord-344988-09vpehvf 297 23 supplementation supplementation NN cord-344988-09vpehvf 297 24 as as IN cord-344988-09vpehvf 297 25 an an DT cord-344988-09vpehvf 297 26 adjunct adjunct NN cord-344988-09vpehvf 297 27 to to IN cord-344988-09vpehvf 297 28 zidovudine zidovudine FW cord-344988-09vpehvf 297 29 ( ( -LRB- cord-344988-09vpehvf 297 30 AZT AZT NNP cord-344988-09vpehvf 297 31 ) ) -RRB- cord-344988-09vpehvf 297 32 therapy therapy NN cord-344988-09vpehvf 297 33 against against IN cord-344988-09vpehvf 297 34 opportunistic opportunistic JJ cord-344988-09vpehvf 297 35 infections infection NNS cord-344988-09vpehvf 297 36 in in IN cord-344988-09vpehvf 297 37 AIDS AIDS NNP cord-344988-09vpehvf 297 38 Experimental experimental JJ cord-344988-09vpehvf 297 39 zinc zinc NN cord-344988-09vpehvf 297 40 deficiency deficiency NN cord-344988-09vpehvf 297 41 : : : cord-344988-09vpehvf 297 42 effects effect NNS cord-344988-09vpehvf 297 43 on on IN cord-344988-09vpehvf 297 44 cellular cellular JJ cord-344988-09vpehvf 297 45 responses response NNS cord-344988-09vpehvf 297 46 and and CC cord-344988-09vpehvf 297 47 the the DT cord-344988-09vpehvf 297 48 affinity affinity NN cord-344988-09vpehvf 297 49 of of IN cord-344988-09vpehvf 297 50 humoral humoral JJ cord-344988-09vpehvf 297 51 antibody antibody NN cord-344988-09vpehvf 298 1 Acrodermatitis Acrodermatitis NNP cord-344988-09vpehvf 298 2 enteropathica enteropathica NNP cord-344988-09vpehvf 298 3 : : : cord-344988-09vpehvf 298 4 a a DT cord-344988-09vpehvf 298 5 lethal lethal JJ cord-344988-09vpehvf 298 6 inherited inherit VBN cord-344988-09vpehvf 298 7 human human JJ cord-344988-09vpehvf 298 8 zinc zinc NN cord-344988-09vpehvf 298 9 - - HYPH cord-344988-09vpehvf 298 10 deficiency deficiency NN cord-344988-09vpehvf 298 11 disorder disorder NN cord-344988-09vpehvf 298 12 Effect effect NN cord-344988-09vpehvf 298 13 of of IN cord-344988-09vpehvf 298 14 zinc zinc NN cord-344988-09vpehvf 298 15 supplementation supplementation NN cord-344988-09vpehvf 298 16 on on IN cord-344988-09vpehvf 298 17 malaria malaria NN cord-344988-09vpehvf 298 18 and and CC cord-344988-09vpehvf 298 19 other other JJ cord-344988-09vpehvf 298 20 causes cause NNS cord-344988-09vpehvf 298 21 of of IN cord-344988-09vpehvf 298 22 morbidity morbidity NN cord-344988-09vpehvf 298 23 in in IN cord-344988-09vpehvf 298 24 west west JJ cord-344988-09vpehvf 298 25 African african JJ cord-344988-09vpehvf 298 26 children child NNS cord-344988-09vpehvf 298 27 : : : cord-344988-09vpehvf 298 28 randomised randomised JJ cord-344988-09vpehvf 298 29 double double JJ cord-344988-09vpehvf 298 30 blind blind JJ cord-344988-09vpehvf 298 31 placebo placebo NN cord-344988-09vpehvf 298 32 controlled control VBN cord-344988-09vpehvf 298 33 trial trial NN cord-344988-09vpehvf 298 34 Zinc zinc NN cord-344988-09vpehvf 298 35 metabolism metabolism NN cord-344988-09vpehvf 298 36 in in IN cord-344988-09vpehvf 298 37 rheumatoid rheumatoid NN cord-344988-09vpehvf 298 38 arthritis arthritis NN cord-344988-09vpehvf 298 39 : : : cord-344988-09vpehvf 298 40 plasma plasma NN cord-344988-09vpehvf 298 41 and and CC cord-344988-09vpehvf 298 42 urinary urinary JJ cord-344988-09vpehvf 298 43 zinc zinc NN cord-344988-09vpehvf 298 44 and and CC cord-344988-09vpehvf 298 45 relationship relationship NN cord-344988-09vpehvf 298 46 to to IN cord-344988-09vpehvf 298 47 disease disease NN cord-344988-09vpehvf 298 48 activity activity NN cord-344988-09vpehvf 298 49 Zinc Zinc NNP cord-344988-09vpehvf 298 50 therapy therapy NN cord-344988-09vpehvf 298 51 in in IN cord-344988-09vpehvf 298 52 acrodermatitis acrodermatitis NNP cord-344988-09vpehvf 298 53 enteropathica enteropathica NNP cord-344988-09vpehvf 298 54 Trace Trace NNP cord-344988-09vpehvf 298 55 metal metal NN cord-344988-09vpehvf 298 56 composition composition NN cord-344988-09vpehvf 298 57 of of IN cord-344988-09vpehvf 298 58 synovial synovial JJ cord-344988-09vpehvf 298 59 fluid fluid NN cord-344988-09vpehvf 298 60 and and CC cord-344988-09vpehvf 298 61 blood blood NN cord-344988-09vpehvf 298 62 serum serum NN cord-344988-09vpehvf 298 63 of of IN cord-344988-09vpehvf 298 64 patients patient NNS cord-344988-09vpehvf 298 65 with with IN cord-344988-09vpehvf 298 66 rheumatoid rheumatoid NN cord-344988-09vpehvf 298 67 arthritis arthritis NN cord-344988-09vpehvf 299 1 How how WRB cord-344988-09vpehvf 299 2 does do VBZ cord-344988-09vpehvf 299 3 zinc zinc NN cord-344988-09vpehvf 299 4 modify modify VB cord-344988-09vpehvf 299 5 the the DT cord-344988-09vpehvf 299 6 common common JJ cord-344988-09vpehvf 299 7 cold cold NN cord-344988-09vpehvf 299 8 ? ? . cord-344988-09vpehvf 300 1 Clinical clinical JJ cord-344988-09vpehvf 300 2 observations observation NNS cord-344988-09vpehvf 300 3 and and CC cord-344988-09vpehvf 300 4 implications implication NNS cord-344988-09vpehvf 300 5 regarding regard VBG cord-344988-09vpehvf 300 6 mechanism mechanism NN cord-344988-09vpehvf 300 7 of of IN cord-344988-09vpehvf 300 8 action action NN cord-344988-09vpehvf 300 9 Zinc zinc NN cord-344988-09vpehvf 300 10 - - HYPH cord-344988-09vpehvf 300 11 induced induce VBN cord-344988-09vpehvf 300 12 suppression suppression NN cord-344988-09vpehvf 300 13 of of IN cord-344988-09vpehvf 300 14 inflammation inflammation NN cord-344988-09vpehvf 300 15 in in IN cord-344988-09vpehvf 300 16 the the DT cord-344988-09vpehvf 300 17 respiratory respiratory JJ cord-344988-09vpehvf 300 18 tract tract NN cord-344988-09vpehvf 300 19 , , , cord-344988-09vpehvf 300 20 caused cause VBN cord-344988-09vpehvf 300 21 by by IN cord-344988-09vpehvf 300 22 infection infection NN cord-344988-09vpehvf 300 23 with with IN cord-344988-09vpehvf 300 24 human human JJ cord-344988-09vpehvf 300 25 rhinovirus rhinovirus NN cord-344988-09vpehvf 300 26 and and CC cord-344988-09vpehvf 300 27 other other JJ cord-344988-09vpehvf 300 28 irritants irritant NNS cord-344988-09vpehvf 300 29 Free Free NNP cord-344988-09vpehvf 300 30 Radicals Radicals NNPS cord-344988-09vpehvf 300 31 and and CC cord-344988-09vpehvf 300 32 Diabetes diabetes NN cord-344988-09vpehvf 301 1 New new JJ cord-344988-09vpehvf 301 2 insights insight NNS cord-344988-09vpehvf 301 3 about about IN cord-344988-09vpehvf 301 4 iron iron NN cord-344988-09vpehvf 301 5 bioavailability bioavailability NN cord-344988-09vpehvf 301 6 inhibition inhibition NN cord-344988-09vpehvf 301 7 by by IN cord-344988-09vpehvf 301 8 zinc zinc NN cord-344988-09vpehvf 301 9 Effects effect NNS cord-344988-09vpehvf 301 10 of of IN cord-344988-09vpehvf 301 11 short short JJ cord-344988-09vpehvf 301 12 term term NN cord-344988-09vpehvf 301 13 isolated isolate VBN cord-344988-09vpehvf 301 14 zinc zinc NN cord-344988-09vpehvf 301 15 deficiency deficiency NN cord-344988-09vpehvf 301 16 on on IN cord-344988-09vpehvf 301 17 intestinal intestinal JJ cord-344988-09vpehvf 301 18 growth growth NN cord-344988-09vpehvf 301 19 and and CC cord-344988-09vpehvf 301 20 activities activity NNS cord-344988-09vpehvf 301 21 of of IN cord-344988-09vpehvf 301 22 brush brush NN cord-344988-09vpehvf 301 23 border border NN cord-344988-09vpehvf 301 24 enzymes enzyme NNS cord-344988-09vpehvf 301 25 in in IN cord-344988-09vpehvf 301 26 weaning wean VBG cord-344988-09vpehvf 301 27 rats rat NNS cord-344988-09vpehvf 302 1 A a DT cord-344988-09vpehvf 302 2 novel novel JJ cord-344988-09vpehvf 302 3 form form NN cord-344988-09vpehvf 302 4 of of IN cord-344988-09vpehvf 302 5 host host NN cord-344988-09vpehvf 302 6 defense defense NN cord-344988-09vpehvf 302 7 : : : cord-344988-09vpehvf 302 8 membrane membrane NN cord-344988-09vpehvf 302 9 protection protection NN cord-344988-09vpehvf 302 10 by by IN cord-344988-09vpehvf 302 11 Ca Ca NNP cord-344988-09vpehvf 302 12 2 2 CD cord-344988-09vpehvf 303 1 + + UH cord-344988-09vpehvf 303 2 and and CC cord-344988-09vpehvf 303 3 Zn Zn NNP cord-344988-09vpehvf 303 4 2 2 CD cord-344988-09vpehvf 304 1 + + CC cord-344988-09vpehvf 304 2 Effect effect NN cord-344988-09vpehvf 304 3 of of IN cord-344988-09vpehvf 304 4 zinc zinc NN cord-344988-09vpehvf 304 5 on on IN cord-344988-09vpehvf 304 6 leukocyte leukocyte NN cord-344988-09vpehvf 304 7 sodium sodium NN cord-344988-09vpehvf 304 8 transport transport NN cord-344988-09vpehvf 304 9 in in IN cord-344988-09vpehvf 304 10 vivo vivo FW cord-344988-09vpehvf 304 11 Effects effect NNS cord-344988-09vpehvf 304 12 of of IN cord-344988-09vpehvf 304 13 zinc zinc NN cord-344988-09vpehvf 304 14 supplementation supplementation NN cord-344988-09vpehvf 304 15 on on IN cord-344988-09vpehvf 304 16 the the DT cord-344988-09vpehvf 304 17 phagocytic phagocytic JJ cord-344988-09vpehvf 304 18 functions function NNS cord-344988-09vpehvf 304 19 of of IN cord-344988-09vpehvf 304 20 polymorphonuclears polymorphonuclear NNS cord-344988-09vpehvf 304 21 in in IN cord-344988-09vpehvf 304 22 patients patient NNS cord-344988-09vpehvf 304 23 with with IN cord-344988-09vpehvf 304 24 inflammatory inflammatory JJ cord-344988-09vpehvf 304 25 rheumatic rheumatic JJ cord-344988-09vpehvf 304 26 diseases disease NNS cord-344988-09vpehvf 304 27 Phosphorylation Phosphorylation NNP cord-344988-09vpehvf 304 28 of of IN cord-344988-09vpehvf 304 29 the the DT cord-344988-09vpehvf 304 30 lymphoid lymphoid JJ cord-344988-09vpehvf 304 31 cell cell NN cord-344988-09vpehvf 304 32 kinase kinase NN cord-344988-09vpehvf 304 33 p56lck p56lck NN cord-344988-09vpehvf 304 34 is be VBZ cord-344988-09vpehvf 304 35 stimulated stimulate VBN cord-344988-09vpehvf 304 36 by by IN cord-344988-09vpehvf 304 37 micromolar micromolar JJ cord-344988-09vpehvf 304 38 concentrations concentration NNS cord-344988-09vpehvf 304 39 of of IN cord-344988-09vpehvf 304 40 Zn Zn NNP cord-344988-09vpehvf 304 41 2 2 CD cord-344988-09vpehvf 304 42 + + CC cord-344988-09vpehvf 304 43 Zinc zinc NN cord-344988-09vpehvf 304 44 is be VBZ cord-344988-09vpehvf 304 45 a a DT cord-344988-09vpehvf 304 46 potent potent JJ cord-344988-09vpehvf 304 47 inhibitor inhibitor NN cord-344988-09vpehvf 304 48 of of IN cord-344988-09vpehvf 304 49 the the DT cord-344988-09vpehvf 304 50 apoptotic apoptotic JJ cord-344988-09vpehvf 304 51 protease protease NN cord-344988-09vpehvf 304 52 , , , cord-344988-09vpehvf 304 53 caspase-3 caspase-3 NNP cord-344988-09vpehvf 304 54 . . . cord-344988-09vpehvf 305 1 A a DT cord-344988-09vpehvf 305 2 novel novel JJ cord-344988-09vpehvf 305 3 target target NN cord-344988-09vpehvf 305 4 for for IN cord-344988-09vpehvf 305 5 zinc zinc NN cord-344988-09vpehvf 305 6 in in IN cord-344988-09vpehvf 305 7 the the DT cord-344988-09vpehvf 305 8 inhibition inhibition NN cord-344988-09vpehvf 305 9 of of IN cord-344988-09vpehvf 305 10 apoptosis apoptosis NN cord-344988-09vpehvf 305 11 Inhibition inhibition NN cord-344988-09vpehvf 305 12 of of IN cord-344988-09vpehvf 305 13 myoblast myoblast NN cord-344988-09vpehvf 305 14 differentiation differentiation NN cord-344988-09vpehvf 305 15 by by IN cord-344988-09vpehvf 305 16 lack lack NN cord-344988-09vpehvf 305 17 of of IN cord-344988-09vpehvf 305 18 zinc zinc NN cord-344988-09vpehvf 305 19 Endotoxin endotoxin NN cord-344988-09vpehvf 305 20 - - HYPH cord-344988-09vpehvf 305 21 induced induce VBN cord-344988-09vpehvf 305 22 inflammation inflammation NN cord-344988-09vpehvf 305 23 does do VBZ cord-344988-09vpehvf 305 24 not not RB cord-344988-09vpehvf 305 25 cause cause VB cord-344988-09vpehvf 305 26 hepatic hepatic JJ cord-344988-09vpehvf 305 27 zinc zinc NN cord-344988-09vpehvf 305 28 accumulation accumulation NN cord-344988-09vpehvf 305 29 in in IN cord-344988-09vpehvf 305 30 mice mouse NNS cord-344988-09vpehvf 305 31 lacking lack VBG cord-344988-09vpehvf 305 32 metallothionein metallothionein NNP cord-344988-09vpehvf 305 33 gene gene NN cord-344988-09vpehvf 305 34 expression expression NN cord-344988-09vpehvf 305 35 Anaemia anaemia NN cord-344988-09vpehvf 305 36 and and CC cord-344988-09vpehvf 305 37 low low JJ cord-344988-09vpehvf 305 38 serum serum NN cord-344988-09vpehvf 305 39 - - HYPH cord-344988-09vpehvf 305 40 copper copper NN cord-344988-09vpehvf 305 41 during during IN cord-344988-09vpehvf 305 42 zinc zinc NN cord-344988-09vpehvf 305 43 therapy therapy NN cord-344988-09vpehvf 306 1 The the DT cord-344988-09vpehvf 306 2 antioxidant antioxidant JJ cord-344988-09vpehvf 306 3 properties property NNS cord-344988-09vpehvf 306 4 of of IN cord-344988-09vpehvf 306 5 zinc zinc NN cord-344988-09vpehvf 306 6 Discovery discovery NN cord-344988-09vpehvf 306 7 and and CC cord-344988-09vpehvf 306 8 importance importance NN cord-344988-09vpehvf 306 9 of of IN cord-344988-09vpehvf 306 10 zinc zinc NN cord-344988-09vpehvf 306 11 in in IN cord-344988-09vpehvf 306 12 human human JJ cord-344988-09vpehvf 306 13 nutrition nutrition NN cord-344988-09vpehvf 306 14 Effects effect NNS cord-344988-09vpehvf 306 15 of of IN cord-344988-09vpehvf 306 16 zinc zinc NN cord-344988-09vpehvf 306 17 deficiency deficiency NN cord-344988-09vpehvf 306 18 on on IN cord-344988-09vpehvf 306 19 Th1 Th1 NNP cord-344988-09vpehvf 306 20 and and CC cord-344988-09vpehvf 306 21 Th2 Th2 NNP cord-344988-09vpehvf 306 22 cytokine cytokine NN cord-344988-09vpehvf 306 23 shifts shift NNS cord-344988-09vpehvf 307 1 Antioxidant antioxidant JJ cord-344988-09vpehvf 307 2 effect effect NN cord-344988-09vpehvf 307 3 of of IN cord-344988-09vpehvf 307 4 zinc zinc NN cord-344988-09vpehvf 307 5 in in IN cord-344988-09vpehvf 307 6 humans human NNS cord-344988-09vpehvf 307 7 Zinc Zinc NNP cord-344988-09vpehvf 307 8 deficiency deficiency NN cord-344988-09vpehvf 307 9 affects affect VBZ cord-344988-09vpehvf 307 10 cell cell NN cord-344988-09vpehvf 307 11 cycle cycle NN cord-344988-09vpehvf 307 12 and and CC cord-344988-09vpehvf 307 13 deoxythymidine deoxythymidine NN cord-344988-09vpehvf 307 14 kinase kinase NN cord-344988-09vpehvf 307 15 gene gene NN cord-344988-09vpehvf 307 16 expression expression NN cord-344988-09vpehvf 307 17 in in IN cord-344988-09vpehvf 307 18 HUT-78 HUT-78 NNP cord-344988-09vpehvf 307 19 cells cell NNS cord-344988-09vpehvf 307 20 Hypocupremia Hypocupremia NNP cord-344988-09vpehvf 307 21 induced induce VBN cord-344988-09vpehvf 307 22 by by IN cord-344988-09vpehvf 307 23 zinc zinc NN cord-344988-09vpehvf 307 24 therapy therapy NN cord-344988-09vpehvf 307 25 in in IN cord-344988-09vpehvf 307 26 adults adult NNS cord-344988-09vpehvf 307 27 Zinc Zinc NNP cord-344988-09vpehvf 307 28 metabolism metabolism NN cord-344988-09vpehvf 307 29 in in IN cord-344988-09vpehvf 307 30 patients patient NNS cord-344988-09vpehvf 307 31 with with IN cord-344988-09vpehvf 307 32 the the DT cord-344988-09vpehvf 307 33 syndrome syndrome NN cord-344988-09vpehvf 307 34 of of IN cord-344988-09vpehvf 307 35 iron iron NN cord-344988-09vpehvf 307 36 deficiency deficiency NN cord-344988-09vpehvf 307 37 anemia anemia NN cord-344988-09vpehvf 307 38 , , , cord-344988-09vpehvf 307 39 hepatosplenomegaly hepatosplenomegaly NNP cord-344988-09vpehvf 307 40 , , , cord-344988-09vpehvf 307 41 dwarfism dwarfism NN cord-344988-09vpehvf 307 42 , , , cord-344988-09vpehvf 307 43 and and CC cord-344988-09vpehvf 307 44 hypogonadism hypogonadism NN cord-344988-09vpehvf 307 45 Effect Effect NNP cord-344988-09vpehvf 307 46 of of IN cord-344988-09vpehvf 307 47 zinc zinc NN cord-344988-09vpehvf 307 48 or or CC cord-344988-09vpehvf 307 49 zinc zinc NN cord-344988-09vpehvf 307 50 plus plus CC cord-344988-09vpehvf 307 51 arginine arginine NN cord-344988-09vpehvf 307 52 supplementation supplementation NN cord-344988-09vpehvf 307 53 on on IN cord-344988-09vpehvf 307 54 antibody antibody NN cord-344988-09vpehvf 307 55 titre titre NN cord-344988-09vpehvf 307 56 and and CC cord-344988-09vpehvf 307 57 lymphocyte lymphocyte NN cord-344988-09vpehvf 307 58 subsets subset NNS cord-344988-09vpehvf 307 59 after after IN cord-344988-09vpehvf 307 60 influenza influenza NN cord-344988-09vpehvf 307 61 vaccination vaccination NN cord-344988-09vpehvf 307 62 in in IN cord-344988-09vpehvf 307 63 elderly elderly JJ cord-344988-09vpehvf 307 64 subjects subject NNS cord-344988-09vpehvf 307 65 : : : cord-344988-09vpehvf 307 66 a a DT cord-344988-09vpehvf 307 67 randomized randomized JJ cord-344988-09vpehvf 307 68 controlled control VBN cord-344988-09vpehvf 307 69 trial trial NN cord-344988-09vpehvf 307 70 Suppressive suppressive JJ cord-344988-09vpehvf 307 71 effect effect NN cord-344988-09vpehvf 307 72 of of IN cord-344988-09vpehvf 307 73 zinc zinc NN cord-344988-09vpehvf 307 74 on on IN cord-344988-09vpehvf 307 75 antibody antibody NN cord-344988-09vpehvf 307 76 response response NN cord-344988-09vpehvf 307 77 to to IN cord-344988-09vpehvf 307 78 cholera cholera NN cord-344988-09vpehvf 307 79 toxin toxin NN cord-344988-09vpehvf 307 80 in in IN cord-344988-09vpehvf 307 81 children child NNS cord-344988-09vpehvf 307 82 given give VBN cord-344988-09vpehvf 307 83 the the DT cord-344988-09vpehvf 307 84 killed kill VBN cord-344988-09vpehvf 307 85 , , , cord-344988-09vpehvf 307 86 B B NNP cord-344988-09vpehvf 307 87 subunit subunit NN cord-344988-09vpehvf 307 88 - - HYPH cord-344988-09vpehvf 307 89 whole whole JJ cord-344988-09vpehvf 307 90 cell cell NN cord-344988-09vpehvf 307 91 , , , cord-344988-09vpehvf 307 92 oral oral JJ cord-344988-09vpehvf 307 93 cholera cholera NN cord-344988-09vpehvf 307 94 vaccine vaccine NN cord-344988-09vpehvf 307 95 Effects effect NNS cord-344988-09vpehvf 307 96 of of IN cord-344988-09vpehvf 307 97 zinc zinc NN cord-344988-09vpehvf 307 98 supplementation supplementation NN cord-344988-09vpehvf 307 99 as as IN cord-344988-09vpehvf 307 100 adjunct adjunct JJ cord-344988-09vpehvf 307 101 therapy therapy NN cord-344988-09vpehvf 307 102 on on IN cord-344988-09vpehvf 307 103 the the DT cord-344988-09vpehvf 307 104 systemic systemic JJ cord-344988-09vpehvf 307 105 immune immune JJ cord-344988-09vpehvf 307 106 responses response NNS cord-344988-09vpehvf 307 107 in in IN cord-344988-09vpehvf 307 108 shigellosis shigellosis NN cord-344988-09vpehvf 307 109 Effect Effect NNP cord-344988-09vpehvf 307 110 of of IN cord-344988-09vpehvf 307 111 zinc zinc NN cord-344988-09vpehvf 307 112 supplementation supplementation NN cord-344988-09vpehvf 307 113 on on IN cord-344988-09vpehvf 307 114 immune immune JJ cord-344988-09vpehvf 307 115 and and CC cord-344988-09vpehvf 307 116 inflammatory inflammatory JJ cord-344988-09vpehvf 307 117 responses response NNS cord-344988-09vpehvf 307 118 in in IN cord-344988-09vpehvf 307 119 pediatric pediatric JJ cord-344988-09vpehvf 307 120 patients patient NNS cord-344988-09vpehvf 307 121 with with IN cord-344988-09vpehvf 307 122 shigellosis shigellosis NN cord-344988-09vpehvf 307 123 Lack lack NN cord-344988-09vpehvf 307 124 of of IN cord-344988-09vpehvf 307 125 beneficial beneficial JJ cord-344988-09vpehvf 307 126 effect effect NN cord-344988-09vpehvf 307 127 of of IN cord-344988-09vpehvf 307 128 zinc zinc NN cord-344988-09vpehvf 307 129 sulphate sulphate NN cord-344988-09vpehvf 307 130 in in IN cord-344988-09vpehvf 307 131 rheumatoid rheumatoid NN cord-344988-09vpehvf 307 132 arthritis arthritis NN cord-344988-09vpehvf 307 133 Zinc Zinc NNP cord-344988-09vpehvf 307 134 supplementation supplementation NN cord-344988-09vpehvf 307 135 does do VBZ cord-344988-09vpehvf 307 136 not not RB cord-344988-09vpehvf 307 137 enhance enhance VB cord-344988-09vpehvf 307 138 antibody antibody NN cord-344988-09vpehvf 307 139 formation formation NN cord-344988-09vpehvf 307 140 to to IN cord-344988-09vpehvf 307 141 influenza influenza NN cord-344988-09vpehvf 307 142 virus virus NN cord-344988-09vpehvf 307 143 vaccine vaccine NN cord-344988-09vpehvf 307 144 in in IN cord-344988-09vpehvf 307 145 the the DT cord-344988-09vpehvf 307 146 elderly elderly JJ cord-344988-09vpehvf 307 147 Zinc zinc NN cord-344988-09vpehvf 307 148 and and CC cord-344988-09vpehvf 307 149 iron iron NN cord-344988-09vpehvf 307 150 supplementation supplementation NN cord-344988-09vpehvf 307 151 and and CC cord-344988-09vpehvf 307 152 malaria malaria NN cord-344988-09vpehvf 307 153 , , , cord-344988-09vpehvf 307 154 diarrhea diarrhea NN cord-344988-09vpehvf 307 155 , , , cord-344988-09vpehvf 307 156 and and CC cord-344988-09vpehvf 307 157 respiratory respiratory JJ cord-344988-09vpehvf 307 158 infections infection NNS cord-344988-09vpehvf 307 159 in in IN cord-344988-09vpehvf 307 160 children child NNS cord-344988-09vpehvf 307 161 in in IN cord-344988-09vpehvf 307 162 the the DT cord-344988-09vpehvf 307 163 Peruvian peruvian JJ cord-344988-09vpehvf 307 164 Amazon Amazon NNP cord-344988-09vpehvf 307 165 Extracellular Extracellular NNP cord-344988-09vpehvf 307 166 and and CC cord-344988-09vpehvf 307 167 immunological immunological JJ cord-344988-09vpehvf 307 168 actions action NNS cord-344988-09vpehvf 307 169 of of IN cord-344988-09vpehvf 307 170 zinc zinc NN cord-344988-09vpehvf 307 171 Zinc zinc NN cord-344988-09vpehvf 307 172 homeostasis homeostasis NN cord-344988-09vpehvf 307 173 and and CC cord-344988-09vpehvf 307 174 immunity immunity NN cord-344988-09vpehvf 307 175 Absorption absorption NN cord-344988-09vpehvf 307 176 of of IN cord-344988-09vpehvf 307 177 zinc zinc NN cord-344988-09vpehvf 307 178 sulfate sulfate NN cord-344988-09vpehvf 307 179 , , , cord-344988-09vpehvf 307 180 methionine methionine NN cord-344988-09vpehvf 307 181 , , , cord-344988-09vpehvf 307 182 and and CC cord-344988-09vpehvf 307 183 polyascorbate polyascorbate NN cord-344988-09vpehvf 307 184 in in IN cord-344988-09vpehvf 307 185 the the DT cord-344988-09vpehvf 307 186 presence presence NN cord-344988-09vpehvf 307 187 and and CC cord-344988-09vpehvf 307 188 absence absence NN cord-344988-09vpehvf 307 189 of of IN cord-344988-09vpehvf 307 190 a a DT cord-344988-09vpehvf 307 191 plant plant NN cord-344988-09vpehvf 307 192 based base VBN cord-344988-09vpehvf 307 193 rural rural JJ cord-344988-09vpehvf 307 194 mexican mexican JJ cord-344988-09vpehvf 307 195 diet diet NN cord-344988-09vpehvf 307 196 Influence influence NN cord-344988-09vpehvf 307 197 of of IN cord-344988-09vpehvf 307 198 highly highly RB cord-344988-09vpehvf 307 199 active active JJ cord-344988-09vpehvf 307 200 antiretroviral antiretroviral JJ cord-344988-09vpehvf 307 201 therapy therapy NN cord-344988-09vpehvf 307 202 on on IN cord-344988-09vpehvf 307 203 micronutrient micronutrient NN cord-344988-09vpehvf 307 204 profiles profile NNS cord-344988-09vpehvf 307 205 in in IN cord-344988-09vpehvf 307 206 HIV HIV NNP cord-344988-09vpehvf 307 207 - - HYPH cord-344988-09vpehvf 307 208 infected infect VBN cord-344988-09vpehvf 307 209 patients patient NNS cord-344988-09vpehvf 308 1 Thymulin Thymulin NNP cord-344988-09vpehvf 308 2 modulates modulate VBZ cord-344988-09vpehvf 308 3 cytokine cytokine NN cord-344988-09vpehvf 308 4 release release NN cord-344988-09vpehvf 308 5 by by IN cord-344988-09vpehvf 308 6 peripheral peripheral JJ cord-344988-09vpehvf 308 7 blood blood NN cord-344988-09vpehvf 308 8 mononuclear mononuclear NN cord-344988-09vpehvf 308 9 cells cell NNS cord-344988-09vpehvf 308 10 : : : cord-344988-09vpehvf 309 1 a a DT cord-344988-09vpehvf 309 2 comparison comparison NN cord-344988-09vpehvf 309 3 between between IN cord-344988-09vpehvf 309 4 healthy healthy JJ cord-344988-09vpehvf 309 5 volunteers volunteer NNS cord-344988-09vpehvf 309 6 and and CC cord-344988-09vpehvf 309 7 patients patient NNS cord-344988-09vpehvf 309 8 with with IN cord-344988-09vpehvf 309 9 systemic systemic JJ cord-344988-09vpehvf 309 10 lupus lupus NN cord-344988-09vpehvf 309 11 erythematodes erythematode NNS cord-344988-09vpehvf 310 1 Zinc zinc NN cord-344988-09vpehvf 310 2 induces induce VBZ cord-344988-09vpehvf 310 3 thymulin thymulin JJ cord-344988-09vpehvf 310 4 secretion secretion NN cord-344988-09vpehvf 310 5 from from IN cord-344988-09vpehvf 310 6 human human JJ cord-344988-09vpehvf 310 7 thymic thymic JJ cord-344988-09vpehvf 310 8 epithelial epithelial JJ cord-344988-09vpehvf 310 9 cells cell NNS cord-344988-09vpehvf 310 10 in in IN cord-344988-09vpehvf 310 11 vitro vitro FW cord-344988-09vpehvf 310 12 and and CC cord-344988-09vpehvf 310 13 augments augment VBZ cord-344988-09vpehvf 310 14 splenocyte splenocyte NNP cord-344988-09vpehvf 310 15 and and CC cord-344988-09vpehvf 310 16 thymocyte thymocyte NNP cord-344988-09vpehvf 310 17 responses response NNS cord-344988-09vpehvf 310 18 in in IN cord-344988-09vpehvf 310 19 vivo vivo NNP cord-344988-09vpehvf 310 20 Induction Induction NNP cord-344988-09vpehvf 310 21 of of IN cord-344988-09vpehvf 310 22 interferon interferon NN cord-344988-09vpehvf 310 23 - - HYPH cord-344988-09vpehvf 310 24 γ γ NN cord-344988-09vpehvf 310 25 in in IN cord-344988-09vpehvf 310 26 human human JJ cord-344988-09vpehvf 310 27 leukocyte leukocyte NN cord-344988-09vpehvf 310 28 cultures culture NNS cord-344988-09vpehvf 310 29 stimulated stimulate VBN cord-344988-09vpehvf 310 30 by by IN cord-344988-09vpehvf 310 31 Zn Zn NNP cord-344988-09vpehvf 310 32 2 2 CD cord-344988-09vpehvf 310 33 + + CC cord-344988-09vpehvf 310 34 Zinc zinc NN cord-344988-09vpehvf 310 35 status status NN cord-344988-09vpehvf 310 36 and and CC cord-344988-09vpehvf 310 37 immune immune JJ cord-344988-09vpehvf 310 38 system system NN cord-344988-09vpehvf 310 39 relationship relationship NN cord-344988-09vpehvf 310 40 Zinc Zinc NNP cord-344988-09vpehvf 310 41 as as IN cord-344988-09vpehvf 310 42 an an DT cord-344988-09vpehvf 310 43 essential essential JJ cord-344988-09vpehvf 310 44 micronutrient micronutrient NN cord-344988-09vpehvf 310 45 : : : cord-344988-09vpehvf 310 46 a a DT cord-344988-09vpehvf 310 47 review review NN cord-344988-09vpehvf 310 48 Excessive excessive JJ cord-344988-09vpehvf 310 49 oral oral JJ cord-344988-09vpehvf 310 50 zinc zinc NN cord-344988-09vpehvf 310 51 supplementation supplementation NN cord-344988-09vpehvf 310 52 Oxygen oxygen NN cord-344988-09vpehvf 310 53 free free JJ cord-344988-09vpehvf 310 54 radicals radical NNS cord-344988-09vpehvf 310 55 and and CC cord-344988-09vpehvf 310 56 metallothionein metallothionein NNP cord-344988-09vpehvf 310 57 . . . cord-344988-09vpehvf 311 1 Free Free NNP cord-344988-09vpehvf 311 2 Radic Radic NNP cord-344988-09vpehvf 311 3 Zinc Zinc NNP cord-344988-09vpehvf 311 4 supplementation supplementation NN cord-344988-09vpehvf 311 5 reduces reduce VBZ cord-344988-09vpehvf 311 6 the the DT cord-344988-09vpehvf 311 7 incidence incidence NN cord-344988-09vpehvf 311 8 of of IN cord-344988-09vpehvf 311 9 acute acute JJ cord-344988-09vpehvf 311 10 lower low JJR cord-344988-09vpehvf 311 11 respiratory respiratory JJ cord-344988-09vpehvf 311 12 infections infection NNS cord-344988-09vpehvf 311 13 in in IN cord-344988-09vpehvf 311 14 infants infant NNS cord-344988-09vpehvf 311 15 and and CC cord-344988-09vpehvf 311 16 preschool preschool NN cord-344988-09vpehvf 311 17 children child NNS cord-344988-09vpehvf 311 18 : : : cord-344988-09vpehvf 311 19 a a DT cord-344988-09vpehvf 311 20 double double JJ cord-344988-09vpehvf 311 21 - - HYPH cord-344988-09vpehvf 311 22 blind blind JJ cord-344988-09vpehvf 311 23 , , , cord-344988-09vpehvf 311 24 controlled control VBN cord-344988-09vpehvf 311 25 trial trial NN cord-344988-09vpehvf 311 26 Bioavailability Bioavailability NNP cord-344988-09vpehvf 311 27 of of IN cord-344988-09vpehvf 311 28 zinc zinc NN cord-344988-09vpehvf 311 29 from from IN cord-344988-09vpehvf 311 30 zinc zinc NN cord-344988-09vpehvf 311 31 - - HYPH cord-344988-09vpehvf 311 32 histidine histidine NN cord-344988-09vpehvf 311 33 complexes complex NNS cord-344988-09vpehvf 311 34 . . . cord-344988-09vpehvf 312 1 I. I. NNP cord-344988-09vpehvf 312 2 Comparison Comparison NNP cord-344988-09vpehvf 312 3 with with IN cord-344988-09vpehvf 312 4 zinc zinc NN cord-344988-09vpehvf 312 5 sulfate sulfate NN cord-344988-09vpehvf 312 6 in in IN cord-344988-09vpehvf 312 7 healthy healthy JJ cord-344988-09vpehvf 312 8 men man NNS cord-344988-09vpehvf 313 1 Interleukin Interleukin NNP cord-344988-09vpehvf 313 2 6 6 CD cord-344988-09vpehvf 313 3 regulates regulate VBZ cord-344988-09vpehvf 313 4 metallothionein metallothionein NNP cord-344988-09vpehvf 313 5 gene gene NN cord-344988-09vpehvf 313 6 expression expression NN cord-344988-09vpehvf 313 7 and and CC cord-344988-09vpehvf 313 8 zinc zinc NN cord-344988-09vpehvf 313 9 metabolism metabolism NN cord-344988-09vpehvf 313 10 in in IN cord-344988-09vpehvf 313 11 hepatocyte hepatocyte NN cord-344988-09vpehvf 313 12 monolayer monolayer NN cord-344988-09vpehvf 313 13 cultures culture NNS cord-344988-09vpehvf 314 1 Low low JJ cord-344988-09vpehvf 314 2 concentrations concentration NNS cord-344988-09vpehvf 314 3 of of IN cord-344988-09vpehvf 314 4 zinc zinc NN cord-344988-09vpehvf 314 5 in in IN cord-344988-09vpehvf 314 6 gastric gastric JJ cord-344988-09vpehvf 314 7 mucosa mucosa NN cord-344988-09vpehvf 314 8 are be VBP cord-344988-09vpehvf 314 9 associated associate VBN cord-344988-09vpehvf 314 10 with with IN cord-344988-09vpehvf 314 11 increased increase VBN cord-344988-09vpehvf 314 12 severity severity NN cord-344988-09vpehvf 314 13 of of IN cord-344988-09vpehvf 314 14 Helicobacter Helicobacter NNP cord-344988-09vpehvf 314 15 pylori pylori NN cord-344988-09vpehvf 314 16 - - HYPH cord-344988-09vpehvf 314 17 induced induce VBN cord-344988-09vpehvf 314 18 inflammation inflammation NN cord-344988-09vpehvf 315 1 The the DT cord-344988-09vpehvf 315 2 influence influence NN cord-344988-09vpehvf 315 3 of of IN cord-344988-09vpehvf 315 4 zinc zinc NN cord-344988-09vpehvf 315 5 supplementation supplementation NN cord-344988-09vpehvf 315 6 on on IN cord-344988-09vpehvf 315 7 morbidity morbidity NN cord-344988-09vpehvf 315 8 due due IN cord-344988-09vpehvf 315 9 to to IN cord-344988-09vpehvf 315 10 Plasmodium Plasmodium NNP cord-344988-09vpehvf 315 11 falciparum falciparum NNS cord-344988-09vpehvf 315 12 : : : cord-344988-09vpehvf 315 13 a a DT cord-344988-09vpehvf 315 14 randomized randomized JJ cord-344988-09vpehvf 315 15 trial trial NN cord-344988-09vpehvf 315 16 in in IN cord-344988-09vpehvf 315 17 preschool preschool NN cord-344988-09vpehvf 315 18 children child NNS cord-344988-09vpehvf 315 19 in in IN cord-344988-09vpehvf 315 20 Papua Papua NNP cord-344988-09vpehvf 315 21 New New NNP cord-344988-09vpehvf 315 22 Guinea Guinea NNP cord-344988-09vpehvf 315 23 Zinc Zinc NNP cord-344988-09vpehvf 315 24 and and CC cord-344988-09vpehvf 315 25 immune immune JJ cord-344988-09vpehvf 315 26 function function NN cord-344988-09vpehvf 315 27 : : : cord-344988-09vpehvf 315 28 the the DT cord-344988-09vpehvf 315 29 biological biological JJ cord-344988-09vpehvf 315 30 basis basis NN cord-344988-09vpehvf 315 31 of of IN cord-344988-09vpehvf 315 32 altered altered JJ cord-344988-09vpehvf 315 33 resistance resistance NN cord-344988-09vpehvf 315 34 to to IN cord-344988-09vpehvf 315 35 infection infection NN cord-344988-09vpehvf 315 36 Oral oral JJ cord-344988-09vpehvf 315 37 zinc zinc NN cord-344988-09vpehvf 315 38 sulphate sulphate NN cord-344988-09vpehvf 315 39 in in IN cord-344988-09vpehvf 315 40 the the DT cord-344988-09vpehvf 315 41 treatment treatment NN cord-344988-09vpehvf 315 42 of of IN cord-344988-09vpehvf 315 43 acute acute JJ cord-344988-09vpehvf 315 44 cutaneous cutaneous JJ cord-344988-09vpehvf 315 45 leishmaniasis leishmaniasis NN cord-344988-09vpehvf 315 46 Oral oral JJ cord-344988-09vpehvf 315 47 zinc zinc NN cord-344988-09vpehvf 315 48 sulphate sulphate NN cord-344988-09vpehvf 315 49 in in IN cord-344988-09vpehvf 315 50 rheumatoid rheumatoid NN cord-344988-09vpehvf 315 51 arthritis arthritis NN cord-344988-09vpehvf 315 52 Oxidative oxidative JJ cord-344988-09vpehvf 315 53 stress stress NN cord-344988-09vpehvf 315 54 in in IN cord-344988-09vpehvf 315 55 viral viral JJ cord-344988-09vpehvf 315 56 hepatitis hepatitis NN cord-344988-09vpehvf 315 57 and and CC cord-344988-09vpehvf 315 58 AIDS AIDS NNP cord-344988-09vpehvf 315 59 Biochemical biochemical JJ cord-344988-09vpehvf 315 60 characteristics characteristic NNS cord-344988-09vpehvf 315 61 of of IN cord-344988-09vpehvf 315 62 caspases-3 caspases-3 NNP cord-344988-09vpehvf 316 1 The the DT cord-344988-09vpehvf 316 2 influence influence NN cord-344988-09vpehvf 316 3 of of IN cord-344988-09vpehvf 316 4 zinc zinc NN cord-344988-09vpehvf 316 5 on on IN cord-344988-09vpehvf 316 6 apoptosis apoptosis NN cord-344988-09vpehvf 316 7 Zinc zinc NN cord-344988-09vpehvf 316 8 supplementation supplementation NN cord-344988-09vpehvf 316 9 enhances enhance VBZ cord-344988-09vpehvf 316 10 the the DT cord-344988-09vpehvf 316 11 response response NN cord-344988-09vpehvf 316 12 to to IN cord-344988-09vpehvf 316 13 interferon interferon NN cord-344988-09vpehvf 316 14 therapy therapy NN cord-344988-09vpehvf 316 15 in in IN cord-344988-09vpehvf 316 16 patients patient NNS cord-344988-09vpehvf 316 17 with with IN cord-344988-09vpehvf 316 18 chronic chronic JJ cord-344988-09vpehvf 316 19 hepatitis hepatitis NN cord-344988-09vpehvf 316 20 C c NN cord-344988-09vpehvf 316 21 Dietary dietary JJ cord-344988-09vpehvf 316 22 micronutrient micronutrient NN cord-344988-09vpehvf 316 23 intake intake NN cord-344988-09vpehvf 316 24 and and CC cord-344988-09vpehvf 316 25 risk risk NN cord-344988-09vpehvf 316 26 of of IN cord-344988-09vpehvf 316 27 progression progression NN cord-344988-09vpehvf 316 28 to to IN cord-344988-09vpehvf 316 29 acquired acquire VBN cord-344988-09vpehvf 316 30 immunodeficiency immunodeficiency NN cord-344988-09vpehvf 316 31 syndrome syndrome NN cord-344988-09vpehvf 316 32 ( ( -LRB- cord-344988-09vpehvf 316 33 AIDS AIDS NNP cord-344988-09vpehvf 316 34 ) ) -RRB- cord-344988-09vpehvf 316 35 in in IN cord-344988-09vpehvf 316 36 human human JJ cord-344988-09vpehvf 316 37 immunodeficiency immunodeficiency NN cord-344988-09vpehvf 316 38 virus virus NN cord-344988-09vpehvf 316 39 type type NN cord-344988-09vpehvf 316 40 1 1 CD cord-344988-09vpehvf 316 41 ( ( -LRB- cord-344988-09vpehvf 316 42 HIV-1)-infected hiv-1)-infecte VBN cord-344988-09vpehvf 316 43 homosexual homosexual JJ cord-344988-09vpehvf 316 44 men man NNS cord-344988-09vpehvf 316 45 Effects effect NNS cord-344988-09vpehvf 316 46 of of IN cord-344988-09vpehvf 316 47 micronutrient micronutrient NN cord-344988-09vpehvf 316 48 intake intake NN cord-344988-09vpehvf 316 49 on on IN cord-344988-09vpehvf 316 50 survival survival NN cord-344988-09vpehvf 316 51 in in IN cord-344988-09vpehvf 316 52 human human JJ cord-344988-09vpehvf 316 53 immunodeficiency immunodeficiency NN cord-344988-09vpehvf 316 54 virus virus NN cord-344988-09vpehvf 316 55 type type NN cord-344988-09vpehvf 316 56 1 1 CD cord-344988-09vpehvf 316 57 infection infection NN cord-344988-09vpehvf 317 1 The the DT cord-344988-09vpehvf 317 2 role role NN cord-344988-09vpehvf 317 3 of of IN cord-344988-09vpehvf 317 4 zinc zinc NN cord-344988-09vpehvf 317 5 in in IN cord-344988-09vpehvf 317 6 caspase caspase NN cord-344988-09vpehvf 317 7 activation activation NN cord-344988-09vpehvf 317 8 and and CC cord-344988-09vpehvf 317 9 apoptotic apoptotic JJ cord-344988-09vpehvf 317 10 cell cell NN cord-344988-09vpehvf 317 11 death death NN cord-344988-09vpehvf 317 12 Effects effect NNS cord-344988-09vpehvf 317 13 of of IN cord-344988-09vpehvf 317 14 zinc zinc NN cord-344988-09vpehvf 317 15 supplementation supplementation NN cord-344988-09vpehvf 317 16 on on IN cord-344988-09vpehvf 317 17 the the DT cord-344988-09vpehvf 317 18 immune immune JJ cord-344988-09vpehvf 317 19 system system NN cord-344988-09vpehvf 317 20 and and CC cord-344988-09vpehvf 317 21 on on IN cord-344988-09vpehvf 317 22 antibody antibody NN cord-344988-09vpehvf 317 23 response response NN cord-344988-09vpehvf 317 24 to to IN cord-344988-09vpehvf 317 25 multivalent multivalent JJ cord-344988-09vpehvf 317 26 influenza influenza NN cord-344988-09vpehvf 317 27 vaccine vaccine NN cord-344988-09vpehvf 317 28 in in IN cord-344988-09vpehvf 317 29 hemodialysis hemodialysis NN cord-344988-09vpehvf 317 30 patients patient NNS cord-344988-09vpehvf 317 31 Interaction Interaction NNP cord-344988-09vpehvf 317 32 of of IN cord-344988-09vpehvf 317 33 the the DT cord-344988-09vpehvf 317 34 unique unique JJ cord-344988-09vpehvf 317 35 N n CD cord-344988-09vpehvf 317 36 - - HYPH cord-344988-09vpehvf 317 37 terminal terminal NN cord-344988-09vpehvf 317 38 region region NN cord-344988-09vpehvf 317 39 of of IN cord-344988-09vpehvf 317 40 tyrosine tyrosine NN cord-344988-09vpehvf 317 41 kinase kinase NN cord-344988-09vpehvf 317 42 p56lck p56lck JJ cord-344988-09vpehvf 317 43 with with IN cord-344988-09vpehvf 317 44 cytoplasmic cytoplasmic JJ cord-344988-09vpehvf 317 45 domains domain NNS cord-344988-09vpehvf 317 46 of of IN cord-344988-09vpehvf 317 47 CD4 CD4 NNP cord-344988-09vpehvf 317 48 and and CC cord-344988-09vpehvf 317 49 CD8 CD8 NNP cord-344988-09vpehvf 317 50 is be VBZ cord-344988-09vpehvf 317 51 mediated mediate VBN cord-344988-09vpehvf 317 52 by by IN cord-344988-09vpehvf 317 53 cysteine cysteine NN cord-344988-09vpehvf 317 54 motifs motif NNS cord-344988-09vpehvf 318 1 The the DT cord-344988-09vpehvf 318 2 treatment treatment NN cord-344988-09vpehvf 318 3 of of IN cord-344988-09vpehvf 318 4 rhinovirus rhinovirus NN cord-344988-09vpehvf 318 5 infections infection NNS cord-344988-09vpehvf 318 6 : : : cord-344988-09vpehvf 318 7 progress progress NN cord-344988-09vpehvf 318 8 and and CC cord-344988-09vpehvf 318 9 potential potential JJ cord-344988-09vpehvf 318 10 Effect effect NN cord-344988-09vpehvf 318 11 of of IN cord-344988-09vpehvf 318 12 iron iron NN cord-344988-09vpehvf 318 13 , , , cord-344988-09vpehvf 318 14 tin tin NN cord-344988-09vpehvf 318 15 and and CC cord-344988-09vpehvf 318 16 copper copper NN cord-344988-09vpehvf 318 17 on on IN cord-344988-09vpehvf 318 18 zinc zinc NN cord-344988-09vpehvf 318 19 absorption absorption NN cord-344988-09vpehvf 318 20 in in IN cord-344988-09vpehvf 318 21 humans human NNS cord-344988-09vpehvf 319 1 The the DT cord-344988-09vpehvf 319 2 biochemical biochemical JJ cord-344988-09vpehvf 319 3 basis basis NN cord-344988-09vpehvf 319 4 of of IN cord-344988-09vpehvf 319 5 zinc zinc NN cord-344988-09vpehvf 319 6 physiology physiology NN cord-344988-09vpehvf 319 7 Zinc zinc NN cord-344988-09vpehvf 319 8 / / SYM cord-344988-09vpehvf 319 9 copper copper NN cord-344988-09vpehvf 319 10 imbalance imbalance NN cord-344988-09vpehvf 319 11 reflects reflect VBZ cord-344988-09vpehvf 319 12 immune immune JJ cord-344988-09vpehvf 319 13 dysfunction dysfunction NN cord-344988-09vpehvf 319 14 in in IN cord-344988-09vpehvf 319 15 human human JJ cord-344988-09vpehvf 319 16 leishmaniasis leishmaniasis NN cord-344988-09vpehvf 319 17 : : : cord-344988-09vpehvf 319 18 an an DT cord-344988-09vpehvf 319 19 ex ex FW cord-344988-09vpehvf 319 20 vivo vivo NN cord-344988-09vpehvf 319 21 and and CC cord-344988-09vpehvf 319 22 in in IN cord-344988-09vpehvf 319 23 vitro vitro FW cord-344988-09vpehvf 319 24 study study NN cord-344988-09vpehvf 319 25 Zinc Zinc NNP cord-344988-09vpehvf 319 26 supplementation supplementation NN cord-344988-09vpehvf 319 27 to to IN cord-344988-09vpehvf 319 28 HIV-1-infected hiv-1-infecte VBN cord-344988-09vpehvf 319 29 pregnant pregnant JJ cord-344988-09vpehvf 319 30 women woman NNS cord-344988-09vpehvf 319 31 : : : cord-344988-09vpehvf 320 1 Effects effect NNS cord-344988-09vpehvf 320 2 on on IN cord-344988-09vpehvf 320 3 maternal maternal JJ cord-344988-09vpehvf 320 4 anthropometry anthropometry NN cord-344988-09vpehvf 320 5 , , , cord-344988-09vpehvf 320 6 viral viral JJ cord-344988-09vpehvf 320 7 load load NN cord-344988-09vpehvf 320 8 , , , cord-344988-09vpehvf 320 9 and and CC cord-344988-09vpehvf 320 10 early early JJ cord-344988-09vpehvf 320 11 mother mother NN cord-344988-09vpehvf 320 12 - - HYPH cord-344988-09vpehvf 320 13 to to IN cord-344988-09vpehvf 320 14 - - HYPH cord-344988-09vpehvf 320 15 child child NN cord-344988-09vpehvf 320 16 transmission transmission NN cord-344988-09vpehvf 320 17 Zinc zinc NN cord-344988-09vpehvf 320 18 - - HYPH cord-344988-09vpehvf 320 19 dependent dependent JJ cord-344988-09vpehvf 320 20 suppression suppression NN cord-344988-09vpehvf 320 21 of of IN cord-344988-09vpehvf 320 22 TNF TNF NNP cord-344988-09vpehvf 320 23 - - HYPH cord-344988-09vpehvf 320 24 alpha alpha NN cord-344988-09vpehvf 320 25 production production NN cord-344988-09vpehvf 320 26 is be VBZ cord-344988-09vpehvf 320 27 mediated mediate VBN cord-344988-09vpehvf 320 28 by by IN cord-344988-09vpehvf 320 29 protein protein NN cord-344988-09vpehvf 320 30 kinase kinase NN cord-344988-09vpehvf 320 31 A A NNP cord-344988-09vpehvf 320 32 - - HYPH cord-344988-09vpehvf 320 33 induced induce VBN cord-344988-09vpehvf 320 34 inhibition inhibition NN cord-344988-09vpehvf 320 35 of of IN cord-344988-09vpehvf 320 36 Raf-1 Raf-1 NNP cord-344988-09vpehvf 320 37 , , , cord-344988-09vpehvf 320 38 IkappaB IkappaB NNP cord-344988-09vpehvf 320 39 kinase kinase NN cord-344988-09vpehvf 320 40 beta beta NN cord-344988-09vpehvf 320 41 , , , cord-344988-09vpehvf 320 42 and and CC cord-344988-09vpehvf 320 43 NF NF NNP cord-344988-09vpehvf 320 44 - - HYPH cord-344988-09vpehvf 320 45 kappaB kappaB NNP cord-344988-09vpehvf 320 46 Zinc zinc NN cord-344988-09vpehvf 320 47 - - HYPH cord-344988-09vpehvf 320 48 mediated mediate VBN cord-344988-09vpehvf 320 49 inhibition inhibition NN cord-344988-09vpehvf 320 50 of of IN cord-344988-09vpehvf 320 51 cyclic cyclic JJ cord-344988-09vpehvf 320 52 nucleotide nucleotide JJ cord-344988-09vpehvf 320 53 phosphodiesterase phosphodiesterase NN cord-344988-09vpehvf 320 54 activity activity NN cord-344988-09vpehvf 320 55 and and CC cord-344988-09vpehvf 320 56 expression expression NN cord-344988-09vpehvf 320 57 suppresses suppress VBZ cord-344988-09vpehvf 320 58 TNF tnf NN cord-344988-09vpehvf 320 59 - - HYPH cord-344988-09vpehvf 320 60 alpha alpha NN cord-344988-09vpehvf 320 61 and and CC cord-344988-09vpehvf 320 62 IL-1 IL-1 NNP cord-344988-09vpehvf 320 63 beta beta NN cord-344988-09vpehvf 320 64 production production NN cord-344988-09vpehvf 320 65 in in IN cord-344988-09vpehvf 320 66 monocytes monocyte NNS cord-344988-09vpehvf 320 67 by by IN cord-344988-09vpehvf 320 68 elevation elevation NN cord-344988-09vpehvf 320 69 of of IN cord-344988-09vpehvf 320 70 guanosine guanosine NN cord-344988-09vpehvf 320 71 3',5'-cyclic 3',5'-cyclic CD cord-344988-09vpehvf 320 72 monophosphate monophosphate NN cord-344988-09vpehvf 320 73 Zinc Zinc NNP cord-344988-09vpehvf 320 74 during during IN cord-344988-09vpehvf 320 75 and and CC cord-344988-09vpehvf 320 76 in in IN cord-344988-09vpehvf 320 77 convalescence convalescence NN cord-344988-09vpehvf 320 78 from from IN cord-344988-09vpehvf 320 79 diarrhea diarrhea NN cord-344988-09vpehvf 320 80 has have VBZ cord-344988-09vpehvf 320 81 no no DT cord-344988-09vpehvf 320 82 demonstrable demonstrable JJ cord-344988-09vpehvf 320 83 effect effect NN cord-344988-09vpehvf 320 84 on on IN cord-344988-09vpehvf 320 85 subsequent subsequent JJ cord-344988-09vpehvf 320 86 morbidity morbidity NN cord-344988-09vpehvf 320 87 and and CC cord-344988-09vpehvf 320 88 anthropometric anthropometric JJ cord-344988-09vpehvf 320 89 status status NN cord-344988-09vpehvf 320 90 among among IN cord-344988-09vpehvf 320 91 infants infant NNS cord-344988-09vpehvf 320 92 < < XX cord-344988-09vpehvf 320 93 6 6 CD cord-344988-09vpehvf 320 94 mo mo NN cord-344988-09vpehvf 320 95 of of IN cord-344988-09vpehvf 320 96 age age NN cord-344988-09vpehvf 321 1 A a DT cord-344988-09vpehvf 321 2 novel novel JJ cord-344988-09vpehvf 321 3 member member NN cord-344988-09vpehvf 321 4 of of IN cord-344988-09vpehvf 321 5 a a DT cord-344988-09vpehvf 321 6 zinc zinc NN cord-344988-09vpehvf 321 7 transporter transporter NN cord-344988-09vpehvf 321 8 family family NN cord-344988-09vpehvf 321 9 is be VBZ cord-344988-09vpehvf 321 10 defective defective JJ cord-344988-09vpehvf 321 11 in in IN cord-344988-09vpehvf 321 12 acrodermatitis acrodermatitis NNP cord-344988-09vpehvf 321 13 enteropathica enteropathica NNP cord-344988-09vpehvf 321 14 Zinc Zinc NNP cord-344988-09vpehvf 321 15 bioavailability bioavailability NN cord-344988-09vpehvf 321 16 in in IN cord-344988-09vpehvf 321 17 feed feed NN cord-344988-09vpehvf 321 18 - - HYPH cord-344988-09vpehvf 321 19 grade grade NN cord-344988-09vpehvf 321 20 sources source NNS cord-344988-09vpehvf 321 21 of of IN cord-344988-09vpehvf 321 22 zinc zinc NN cord-344988-09vpehvf 321 23 Bioavailability Bioavailability NNP cord-344988-09vpehvf 321 24 of of IN cord-344988-09vpehvf 321 25 zinc zinc NN cord-344988-09vpehvf 321 26 from from IN cord-344988-09vpehvf 321 27 inorganic inorganic JJ cord-344988-09vpehvf 321 28 and and CC cord-344988-09vpehvf 321 29 organic organic JJ cord-344988-09vpehvf 321 30 sources source NNS cord-344988-09vpehvf 321 31 for for IN cord-344988-09vpehvf 321 32 pigs pig NNS cord-344988-09vpehvf 321 33 fed feed VBD cord-344988-09vpehvf 321 34 corn corn NN cord-344988-09vpehvf 321 35 - - HYPH cord-344988-09vpehvf 321 36 soybean soybean NN cord-344988-09vpehvf 321 37 meal meal NN cord-344988-09vpehvf 321 38 diets diet NNS cord-344988-09vpehvf 322 1 The the DT cord-344988-09vpehvf 322 2 immunobiology immunobiology NN cord-344988-09vpehvf 322 3 of of IN cord-344988-09vpehvf 322 4 zinc zinc NN cord-344988-09vpehvf 322 5 Zinc Zinc NNP cord-344988-09vpehvf 322 6 inhibits inhibit VBZ cord-344988-09vpehvf 322 7 IL-1 IL-1 NNP cord-344988-09vpehvf 322 8 dependent dependent JJ cord-344988-09vpehvf 322 9 T T NNP cord-344988-09vpehvf 322 10 cell cell NN cord-344988-09vpehvf 322 11 stimulation stimulation NN cord-344988-09vpehvf 323 1 The the DT cord-344988-09vpehvf 323 2 temporal temporal JJ cord-344988-09vpehvf 323 3 relationship relationship NN cord-344988-09vpehvf 323 4 between between IN cord-344988-09vpehvf 323 5 protein protein NN cord-344988-09vpehvf 323 6 phosphatase phosphatase NN cord-344988-09vpehvf 323 7 , , , cord-344988-09vpehvf 323 8 mitochondrial mitochondrial JJ cord-344988-09vpehvf 323 9 cytochrome cytochrome NN cord-344988-09vpehvf 323 10 c c NN cord-344988-09vpehvf 323 11 release release NN cord-344988-09vpehvf 323 12 , , , cord-344988-09vpehvf 323 13 and and CC cord-344988-09vpehvf 323 14 caspase caspase NN cord-344988-09vpehvf 323 15 activation activation NN cord-344988-09vpehvf 323 16 in in IN cord-344988-09vpehvf 323 17 apoptosis apoptosis NN cord-344988-09vpehvf 323 18 Zinc zinc NN cord-344988-09vpehvf 323 19 in in IN cord-344988-09vpehvf 323 20 DNA dna NN cord-344988-09vpehvf 323 21 replication replication NN cord-344988-09vpehvf 323 22 and and CC cord-344988-09vpehvf 323 23 transcription transcription NN cord-344988-09vpehvf 323 24 Zinc zinc NN cord-344988-09vpehvf 323 25 is be VBZ cord-344988-09vpehvf 323 26 a a DT cord-344988-09vpehvf 323 27 negative negative JJ cord-344988-09vpehvf 323 28 regulator regulator NN cord-344988-09vpehvf 323 29 of of IN cord-344988-09vpehvf 323 30 hepatitis hepatitis NNP cord-344988-09vpehvf 323 31 C C NNP cord-344988-09vpehvf 323 32 virus virus NN cord-344988-09vpehvf 323 33 RNA RNA NNP cord-344988-09vpehvf 323 34 replication replication NN cord-344988-09vpehvf 323 35 Childhood Childhood NNP cord-344988-09vpehvf 323 36 pneumonia pneumonia NN cord-344988-09vpehvf 323 37 -progress -progress NN cord-344988-09vpehvf 323 38 and and CC cord-344988-09vpehvf 323 39 challenges challenge VBZ cord-344988-09vpehvf 323 40 Effect effect NN cord-344988-09vpehvf 323 41 of of IN cord-344988-09vpehvf 323 42 zinc zinc NN cord-344988-09vpehvf 323 43 on on IN cord-344988-09vpehvf 323 44 the the DT cord-344988-09vpehvf 323 45 immune immune JJ cord-344988-09vpehvf 323 46 status status NN cord-344988-09vpehvf 323 47 of of IN cord-344988-09vpehvf 323 48 zinc zinc NN cord-344988-09vpehvf 323 49 - - HYPH cord-344988-09vpehvf 323 50 depleted deplete VBN cord-344988-09vpehvf 323 51 AIDS AIDS NNP cord-344988-09vpehvf 323 52 related relate VBN cord-344988-09vpehvf 323 53 complex complex JJ cord-344988-09vpehvf 323 54 patients patient NNS cord-344988-09vpehvf 323 55 Effect Effect NNP cord-344988-09vpehvf 323 56 of of IN cord-344988-09vpehvf 323 57 zinc zinc NN cord-344988-09vpehvf 323 58 on on IN cord-344988-09vpehvf 323 59 the the DT cord-344988-09vpehvf 323 60 treatment treatment NN cord-344988-09vpehvf 323 61 of of IN cord-344988-09vpehvf 323 62 Plasmodium Plasmodium NNP cord-344988-09vpehvf 323 63 falciparum falciparum NN cord-344988-09vpehvf 323 64 malaria malaria NN cord-344988-09vpehvf 323 65 in in IN cord-344988-09vpehvf 323 66 children child NNS cord-344988-09vpehvf 323 67 : : : cord-344988-09vpehvf 323 68 a a DT cord-344988-09vpehvf 323 69 randomized randomized JJ cord-344988-09vpehvf 323 70 controlled control VBN cord-344988-09vpehvf 323 71 trial trial NN cord-344988-09vpehvf 323 72 Serum serum NN cord-344988-09vpehvf 323 73 zinc zinc NN cord-344988-09vpehvf 323 74 and and CC cord-344988-09vpehvf 323 75 copper copper NN cord-344988-09vpehvf 323 76 in in IN cord-344988-09vpehvf 323 77 active active JJ cord-344988-09vpehvf 323 78 rheumatoid rheumatoid NN cord-344988-09vpehvf 323 79 arthritis arthritis NN cord-344988-09vpehvf 323 80 : : : cord-344988-09vpehvf 323 81 correlation correlation NN cord-344988-09vpehvf 323 82 with with IN cord-344988-09vpehvf 323 83 interleukin interleukin NN cord-344988-09vpehvf 323 84 1 1 CD cord-344988-09vpehvf 323 85 beta beta NN cord-344988-09vpehvf 323 86 and and CC cord-344988-09vpehvf 323 87 tumour tumour NN cord-344988-09vpehvf 323 88 necrosis necrosis NN cord-344988-09vpehvf 323 89 factor factor NN cord-344988-09vpehvf 323 90 alpha alpha NN