id	sid	tid	token	lemma	pos
cord-270337-92a5uwjf	1	1	key	key	NN
cord-270337-92a5uwjf	1	2	:	:	:
cord-270337-92a5uwjf	2	1	cord-270337	cord-270337	JJ
cord-270337-92a5uwjf	2	2	-	-	HYPH
cord-270337-92a5uwjf	2	3	92a5uwjf	92a5uwjf	CD
cord-270337-92a5uwjf	2	4	authors	author	NNS
cord-270337-92a5uwjf	2	5	:	:	:
cord-270337-92a5uwjf	2	6	Hughes	Hughes	NNP
cord-270337-92a5uwjf	2	7	,	,	,
cord-270337-92a5uwjf	2	8	Dyfrig	Dyfrig	NNP
cord-270337-92a5uwjf	2	9	A.	a.	NN
cord-270337-92a5uwjf	2	10	title	title	NN
cord-270337-92a5uwjf	2	11	:	:	:
cord-270337-92a5uwjf	2	12	Acute	acute	JJ
cord-270337-92a5uwjf	2	13	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	2	14	poisoning	poisoning	NN
cord-270337-92a5uwjf	2	15	:	:	:
cord-270337-92a5uwjf	2	16	A	a	DT
cord-270337-92a5uwjf	2	17	comprehensive	comprehensive	JJ
cord-270337-92a5uwjf	2	18	experimental	experimental	JJ
cord-270337-92a5uwjf	2	19	toxicology	toxicology	NN
cord-270337-92a5uwjf	2	20	assessment	assessment	NN
cord-270337-92a5uwjf	2	21	of	of	IN
cord-270337-92a5uwjf	2	22	the	the	DT
cord-270337-92a5uwjf	2	23	role	role	NN
cord-270337-92a5uwjf	2	24	of	of	IN
cord-270337-92a5uwjf	2	25	diazepam	diazepam	NN
cord-270337-92a5uwjf	2	26	date	date	NN
cord-270337-92a5uwjf	2	27	:	:	:
cord-270337-92a5uwjf	2	28	2020	2020	CD
cord-270337-92a5uwjf	2	29	-	-	HYPH
cord-270337-92a5uwjf	2	30	06	06	CD
cord-270337-92a5uwjf	2	31	-	-	SYM
cord-270337-92a5uwjf	2	32	18	18	CD
cord-270337-92a5uwjf	2	33	journal	journal	NN
cord-270337-92a5uwjf	2	34	:	:	:
cord-270337-92a5uwjf	3	1	Br	br	CC
cord-270337-92a5uwjf	3	2	J	J	NNP
cord-270337-92a5uwjf	3	3	Pharmacol	Pharmacol	NNP
cord-270337-92a5uwjf	3	4	DOI	DOI	NNP
cord-270337-92a5uwjf	3	5	:	:	:
cord-270337-92a5uwjf	4	1	10.1111	10.1111	CD
cord-270337-92a5uwjf	4	2	/	/	SYM
cord-270337-92a5uwjf	4	3	bph.15101	bph.15101	XX
cord-270337-92a5uwjf	5	1	sha	sha	NNP
cord-270337-92a5uwjf	5	2	:	:	:
cord-270337-92a5uwjf	6	1	945c78a88346ef68b0c3f61e4e8af2aeb353ce82	945c78a88346ef68b0c3f61e4e8af2aeb353ce82	CD
cord-270337-92a5uwjf	6	2	doc_id	doc_id	CD
cord-270337-92a5uwjf	6	3	:	:	:
cord-270337-92a5uwjf	7	1	270337	270337	CD
cord-270337-92a5uwjf	7	2	cord_uid	cord_uid	NNS
cord-270337-92a5uwjf	7	3	:	:	:
cord-270337-92a5uwjf	8	1	92a5uwjf	92a5uwjf	CD
cord-270337-92a5uwjf	8	2	BACKGROUND	background	NN
cord-270337-92a5uwjf	8	3	AND	and	CC
cord-270337-92a5uwjf	8	4	PURPOSE	purpose	NN
cord-270337-92a5uwjf	8	5	:	:	:
cord-270337-92a5uwjf	9	1	Resurgence	resurgence	NN
cord-270337-92a5uwjf	9	2	in	in	IN
cord-270337-92a5uwjf	9	3	the	the	DT
cord-270337-92a5uwjf	9	4	use	use	NN
cord-270337-92a5uwjf	9	5	of	of	IN
cord-270337-92a5uwjf	9	6	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	9	7	as	as	IN
cord-270337-92a5uwjf	9	8	a	a	DT
cord-270337-92a5uwjf	9	9	potential	potential	JJ
cord-270337-92a5uwjf	9	10	treatment	treatment	NN
cord-270337-92a5uwjf	9	11	for	for	IN
cord-270337-92a5uwjf	9	12	COVID‐19	COVID‐19	NNP
cord-270337-92a5uwjf	9	13	has	have	VBZ
cord-270337-92a5uwjf	9	14	seen	see	VBN
cord-270337-92a5uwjf	9	15	recent	recent	JJ
cord-270337-92a5uwjf	9	16	cases	case	NNS
cord-270337-92a5uwjf	9	17	of	of	IN
cord-270337-92a5uwjf	9	18	fatal	fatal	JJ
cord-270337-92a5uwjf	9	19	toxicity	toxicity	NN
cord-270337-92a5uwjf	9	20	due	due	IN
cord-270337-92a5uwjf	9	21	to	to	IN
cord-270337-92a5uwjf	9	22	unintentional	unintentional	JJ
cord-270337-92a5uwjf	9	23	overdoses	overdose	NNS
cord-270337-92a5uwjf	9	24	.	.	.
cord-270337-92a5uwjf	10	1	Protocols	protocol	NNS
cord-270337-92a5uwjf	10	2	for	for	IN
cord-270337-92a5uwjf	10	3	the	the	DT
cord-270337-92a5uwjf	10	4	management	management	NN
cord-270337-92a5uwjf	10	5	of	of	IN
cord-270337-92a5uwjf	10	6	poisoning	poisoning	NN
cord-270337-92a5uwjf	10	7	recommend	recommend	VBP
cord-270337-92a5uwjf	10	8	diazepam	diazepam	NN
cord-270337-92a5uwjf	10	9	,	,	,
cord-270337-92a5uwjf	10	10	although	although	IN
cord-270337-92a5uwjf	10	11	there	there	EX
cord-270337-92a5uwjf	10	12	are	be	VBP
cord-270337-92a5uwjf	10	13	uncertainties	uncertainty	NNS
cord-270337-92a5uwjf	10	14	in	in	IN
cord-270337-92a5uwjf	10	15	its	-PRON-	PRP$
cord-270337-92a5uwjf	10	16	pharmacology	pharmacology	NN
cord-270337-92a5uwjf	10	17	and	and	CC
cord-270337-92a5uwjf	10	18	efficacy	efficacy	NN
cord-270337-92a5uwjf	10	19	in	in	IN
cord-270337-92a5uwjf	10	20	this	this	DT
cord-270337-92a5uwjf	10	21	context	context	NN
cord-270337-92a5uwjf	10	22	.	.	.
cord-270337-92a5uwjf	11	1	The	the	DT
cord-270337-92a5uwjf	11	2	aim	aim	NN
cord-270337-92a5uwjf	11	3	was	be	VBD
cord-270337-92a5uwjf	11	4	to	to	TO
cord-270337-92a5uwjf	11	5	assess	assess	VB
cord-270337-92a5uwjf	11	6	the	the	DT
cord-270337-92a5uwjf	11	7	effects	effect	NNS
cord-270337-92a5uwjf	11	8	of	of	IN
cord-270337-92a5uwjf	11	9	diazepam	diazepam	NN
cord-270337-92a5uwjf	11	10	in	in	IN
cord-270337-92a5uwjf	11	11	experimental	experimental	JJ
cord-270337-92a5uwjf	11	12	models	model	NNS
cord-270337-92a5uwjf	11	13	of	of	IN
cord-270337-92a5uwjf	11	14	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	11	15	cardiotoxicity	cardiotoxicity	NN
cord-270337-92a5uwjf	11	16	.	.	.
cord-270337-92a5uwjf	12	1	EXPERIMENTAL	experimental	JJ
cord-270337-92a5uwjf	12	2	APPROACH	approach	NN
cord-270337-92a5uwjf	12	3	:	:	:
cord-270337-92a5uwjf	13	1	In	in	IN
cord-270337-92a5uwjf	13	2	vitro	vitro	FW
cord-270337-92a5uwjf	13	3	experiments	experiment	NNS
cord-270337-92a5uwjf	13	4	involved	involve	VBD
cord-270337-92a5uwjf	13	5	cardiac	cardiac	JJ
cord-270337-92a5uwjf	13	6	tissues	tissue	NNS
cord-270337-92a5uwjf	13	7	isolated	isolate	VBN
cord-270337-92a5uwjf	13	8	from	from	IN
cord-270337-92a5uwjf	13	9	rats	rat	NNS
cord-270337-92a5uwjf	13	10	and	and	CC
cord-270337-92a5uwjf	13	11	incubated	incubate	VBN
cord-270337-92a5uwjf	13	12	with	with	IN
cord-270337-92a5uwjf	13	13	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	13	14	alone	alone	RB
cord-270337-92a5uwjf	13	15	or	or	CC
cord-270337-92a5uwjf	13	16	in	in	IN
cord-270337-92a5uwjf	13	17	combination	combination	NN
cord-270337-92a5uwjf	13	18	with	with	IN
cord-270337-92a5uwjf	13	19	diazepam	diazepam	NN
cord-270337-92a5uwjf	13	20	.	.	.
cord-270337-92a5uwjf	14	1	In	in	IN
cord-270337-92a5uwjf	14	2	vivo	vivo	NN
cord-270337-92a5uwjf	14	3	models	model	NNS
cord-270337-92a5uwjf	14	4	of	of	IN
cord-270337-92a5uwjf	14	5	toxicity	toxicity	NN
cord-270337-92a5uwjf	14	6	involved	involve	VBN
cord-270337-92a5uwjf	14	7	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	14	8	administered	administer	VBD
cord-270337-92a5uwjf	14	9	intravenously	intravenously	RB
cord-270337-92a5uwjf	14	10	to	to	IN
cord-270337-92a5uwjf	14	11	pentobarbitone‐anaesthetised	pentobarbitone‐anaesthetised	JJ
cord-270337-92a5uwjf	14	12	rats	rat	NNS
cord-270337-92a5uwjf	14	13	and	and	CC
cord-270337-92a5uwjf	14	14	rabbits	rabbit	NNS
cord-270337-92a5uwjf	14	15	.	.	.
cord-270337-92a5uwjf	15	1	Randomised	randomised	JJ
cord-270337-92a5uwjf	15	2	,	,	,
cord-270337-92a5uwjf	15	3	controlled	control	VBN
cord-270337-92a5uwjf	15	4	treatment	treatment	NN
cord-270337-92a5uwjf	15	5	studies	study	NNS
cord-270337-92a5uwjf	15	6	in	in	IN
cord-270337-92a5uwjf	15	7	rats	rat	NNS
cord-270337-92a5uwjf	15	8	assessed	assess	VBD
cord-270337-92a5uwjf	15	9	diazepam	diazepam	NN
cord-270337-92a5uwjf	15	10	,	,	,
cord-270337-92a5uwjf	15	11	clonazepam	clonazepam	NN
cord-270337-92a5uwjf	15	12	and	and	CC
cord-270337-92a5uwjf	15	13	Ro5‐4864	ro5‐4864	NN
cord-270337-92a5uwjf	15	14	administered	administer	VBN
cord-270337-92a5uwjf	15	15	:	:	:
cord-270337-92a5uwjf	16	1	(	(	-LRB-
cord-270337-92a5uwjf	16	2	i	i	NN
cord-270337-92a5uwjf	16	3	)	)	-RRB-
cord-270337-92a5uwjf	17	1	prior	prior	RB
cord-270337-92a5uwjf	17	2	,	,	,
cord-270337-92a5uwjf	17	3	(	(	-LRB-
cord-270337-92a5uwjf	17	4	ii	ii	NN
cord-270337-92a5uwjf	17	5	)	)	-RRB-
cord-270337-92a5uwjf	17	6	during	during	IN
cord-270337-92a5uwjf	17	7	and	and	CC
cord-270337-92a5uwjf	17	8	(	(	-LRB-
cord-270337-92a5uwjf	17	9	iii	iii	NN
cord-270337-92a5uwjf	17	10	)	)	-RRB-
cord-270337-92a5uwjf	18	1	after	after	IN
cord-270337-92a5uwjf	18	2	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	18	3	and	and	CC
cord-270337-92a5uwjf	18	4	the	the	DT
cord-270337-92a5uwjf	18	5	effects	effect	NNS
cord-270337-92a5uwjf	18	6	of	of	IN
cord-270337-92a5uwjf	18	7	diazepam	diazepam	NN
cord-270337-92a5uwjf	18	8	:	:	:
cord-270337-92a5uwjf	18	9	(	(	-LRB-
cord-270337-92a5uwjf	18	10	iv	iv	LS
cord-270337-92a5uwjf	18	11	)	)	-RRB-
cord-270337-92a5uwjf	18	12	at	at	IN
cord-270337-92a5uwjf	18	13	high	high	JJ
cord-270337-92a5uwjf	18	14	dose	dose	NN
cord-270337-92a5uwjf	18	15	,	,	,
cord-270337-92a5uwjf	18	16	(	(	-LRB-
cord-270337-92a5uwjf	18	17	v	v	NN
cord-270337-92a5uwjf	18	18	)	)	-RRB-
cord-270337-92a5uwjf	19	1	in	in	IN
cord-270337-92a5uwjf	19	2	urethane‐anaesthetised	urethane‐anaesthetised	JJ
cord-270337-92a5uwjf	19	3	rats	rat	NNS
cord-270337-92a5uwjf	19	4	and	and	CC
cord-270337-92a5uwjf	19	5	(	(	-LRB-
cord-270337-92a5uwjf	19	6	vi	vi	NNP
cord-270337-92a5uwjf	19	7	)	)	-RRB-
cord-270337-92a5uwjf	19	8	co‐administered	co‐administere	VBN
cord-270337-92a5uwjf	19	9	with	with	IN
cord-270337-92a5uwjf	19	10	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	19	11	.	.	.
cord-270337-92a5uwjf	20	1	KEY	key	JJ
cord-270337-92a5uwjf	20	2	RESULTS	result	NNS
cord-270337-92a5uwjf	20	3	:	:	:
cord-270337-92a5uwjf	21	1	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	21	2	decreased	decrease	VBD
cord-270337-92a5uwjf	21	3	the	the	DT
cord-270337-92a5uwjf	21	4	developed	develop	VBN
cord-270337-92a5uwjf	21	5	tension	tension	NN
cord-270337-92a5uwjf	21	6	of	of	IN
cord-270337-92a5uwjf	21	7	left	left	JJ
cord-270337-92a5uwjf	21	8	atria	atria	NN
cord-270337-92a5uwjf	21	9	,	,	,
cord-270337-92a5uwjf	21	10	prolonged	prolong	VBD
cord-270337-92a5uwjf	21	11	the	the	DT
cord-270337-92a5uwjf	21	12	effective	effective	JJ
cord-270337-92a5uwjf	21	13	refractory	refractory	JJ
cord-270337-92a5uwjf	21	14	period	period	NN
cord-270337-92a5uwjf	21	15	of	of	IN
cord-270337-92a5uwjf	21	16	atria	atria	NN
cord-270337-92a5uwjf	21	17	,	,	,
cord-270337-92a5uwjf	21	18	ventricular	ventricular	JJ
cord-270337-92a5uwjf	21	19	tissue	tissue	NN
cord-270337-92a5uwjf	21	20	and	and	CC
cord-270337-92a5uwjf	21	21	right	right	JJ
cord-270337-92a5uwjf	21	22	papillary	papillary	JJ
cord-270337-92a5uwjf	21	23	muscles	muscle	NNS
cord-270337-92a5uwjf	21	24	,	,	,
cord-270337-92a5uwjf	21	25	and	and	CC
cord-270337-92a5uwjf	21	26	caused	cause	VBD
cord-270337-92a5uwjf	21	27	dose‐dependent	dose‐dependent	NNP
cord-270337-92a5uwjf	21	28	impairment	impairment	NN
cord-270337-92a5uwjf	21	29	of	of	IN
cord-270337-92a5uwjf	21	30	haemodynamic	haemodynamic	NNP
cord-270337-92a5uwjf	21	31	and	and	CC
cord-270337-92a5uwjf	21	32	electrocardiographic	electrocardiographic	JJ
cord-270337-92a5uwjf	21	33	parameters	parameter	NNS
cord-270337-92a5uwjf	21	34	.	.	.
cord-270337-92a5uwjf	22	1	Cardiac	cardiac	JJ
cord-270337-92a5uwjf	22	2	arrhythmias	arrhythmia	NNS
cord-270337-92a5uwjf	22	3	indicated	indicate	VBD
cord-270337-92a5uwjf	22	4	impairment	impairment	NN
cord-270337-92a5uwjf	22	5	of	of	IN
cord-270337-92a5uwjf	22	6	atrioventricular	atrioventricular	JJ
cord-270337-92a5uwjf	22	7	conduction	conduction	NN
cord-270337-92a5uwjf	22	8	.	.	.
cord-270337-92a5uwjf	23	1	Studies	study	NNS
cord-270337-92a5uwjf	23	2	(	(	-LRB-
cord-270337-92a5uwjf	23	3	i	i	NN
cord-270337-92a5uwjf	23	4	)	)	-RRB-
cord-270337-92a5uwjf	23	5	,	,	,
cord-270337-92a5uwjf	23	6	(	(	-LRB-
cord-270337-92a5uwjf	23	7	ii	ii	NN
cord-270337-92a5uwjf	23	8	)	)	-RRB-
cord-270337-92a5uwjf	23	9	and	and	CC
cord-270337-92a5uwjf	23	10	(	(	-LRB-
cord-270337-92a5uwjf	23	11	v	v	NN
cord-270337-92a5uwjf	23	12	)	)	-RRB-
cord-270337-92a5uwjf	23	13	showed	show	VBD
cord-270337-92a5uwjf	23	14	no	no	DT
cord-270337-92a5uwjf	23	15	differences	difference	NNS
cord-270337-92a5uwjf	23	16	between	between	IN
cord-270337-92a5uwjf	23	17	treatments	treatment	NNS
cord-270337-92a5uwjf	23	18	and	and	CC
cord-270337-92a5uwjf	23	19	control	control	NN
cord-270337-92a5uwjf	23	20	.	.	.
cord-270337-92a5uwjf	24	1	Diazepam	diazepam	NN
cord-270337-92a5uwjf	24	2	increased	increase	VBD
cord-270337-92a5uwjf	24	3	heart	heart	NN
cord-270337-92a5uwjf	24	4	rate	rate	NN
cord-270337-92a5uwjf	24	5	in	in	IN
cord-270337-92a5uwjf	24	6	study	study	NN
cord-270337-92a5uwjf	24	7	(	(	-LRB-
cord-270337-92a5uwjf	24	8	iv	iv	LS
cord-270337-92a5uwjf	24	9	)	)	-RRB-
cord-270337-92a5uwjf	24	10	and	and	CC
cord-270337-92a5uwjf	24	11	as	as	IN
cord-270337-92a5uwjf	24	12	with	with	IN
cord-270337-92a5uwjf	24	13	clonazepam	clonazepam	NN
cord-270337-92a5uwjf	24	14	also	also	RB
cord-270337-92a5uwjf	24	15	prolonged	prolong	VBD
cord-270337-92a5uwjf	24	16	the	the	DT
cord-270337-92a5uwjf	24	17	QTc	qtc	NN
cord-270337-92a5uwjf	24	18	interval	interval	NN
cord-270337-92a5uwjf	24	19	in	in	IN
cord-270337-92a5uwjf	24	20	study	study	NN
cord-270337-92a5uwjf	24	21	(	(	-LRB-
cord-270337-92a5uwjf	24	22	iii	iii	NN
cord-270337-92a5uwjf	24	23	)	)	-RRB-
cord-270337-92a5uwjf	24	24	.	.	.
cord-270337-92a5uwjf	25	1	Combined	combined	JJ
cord-270337-92a5uwjf	25	2	administration	administration	NN
cord-270337-92a5uwjf	25	3	of	of	IN
cord-270337-92a5uwjf	25	4	diazepam	diazepam	NN
cord-270337-92a5uwjf	25	5	and	and	CC
cord-270337-92a5uwjf	25	6	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	25	7	in	in	IN
cord-270337-92a5uwjf	25	8	study	study	NN
cord-270337-92a5uwjf	25	9	(	(	-LRB-
cord-270337-92a5uwjf	25	10	vi	vi	NNP
cord-270337-92a5uwjf	25	11	)	)	-RRB-
cord-270337-92a5uwjf	25	12	improved	improve	VBN
cord-270337-92a5uwjf	25	13	cardiac	cardiac	JJ
cord-270337-92a5uwjf	25	14	contractility	contractility	NN
cord-270337-92a5uwjf	25	15	but	but	CC
cord-270337-92a5uwjf	25	16	caused	cause	VBD
cord-270337-92a5uwjf	25	17	hypokalaemia	hypokalaemia	NN
cord-270337-92a5uwjf	25	18	.	.	.
cord-270337-92a5uwjf	26	1	CONCLUSION	conclusion	NN
cord-270337-92a5uwjf	26	2	AND	and	CC
cord-270337-92a5uwjf	26	3	IMPLICATIONS	implications	NN
cord-270337-92a5uwjf	26	4	:	:	:
cord-270337-92a5uwjf	27	1	Neither	neither	CC
cord-270337-92a5uwjf	27	2	diazepam	diazepam	NN
cord-270337-92a5uwjf	27	3	nor	nor	CC
cord-270337-92a5uwjf	27	4	other	other	JJ
cord-270337-92a5uwjf	27	5	ligands	ligand	NNS
cord-270337-92a5uwjf	27	6	for	for	IN
cord-270337-92a5uwjf	27	7	benzodiazepine	benzodiazepine	NN
cord-270337-92a5uwjf	27	8	binding	bind	VBG
cord-270337-92a5uwjf	27	9	sites	site	NNS
cord-270337-92a5uwjf	27	10	protect	protect	VBP
cord-270337-92a5uwjf	27	11	against	against	IN
cord-270337-92a5uwjf	27	12	or	or	CC
cord-270337-92a5uwjf	27	13	attenuate	attenuate	VB
cord-270337-92a5uwjf	27	14	chloroquine	chloroquine	JJ
cord-270337-92a5uwjf	27	15	cardiotoxicity	cardiotoxicity	NN
cord-270337-92a5uwjf	27	16	.	.	.
cord-270337-92a5uwjf	28	1	However	however	RB
cord-270337-92a5uwjf	28	2	,	,	,
cord-270337-92a5uwjf	28	3	diazepam	diazepam	NNP
cord-270337-92a5uwjf	28	4	may	may	MD
cord-270337-92a5uwjf	28	5	augment	augment	VB
cord-270337-92a5uwjf	28	6	the	the	DT
cord-270337-92a5uwjf	28	7	effects	effect	NNS
cord-270337-92a5uwjf	28	8	of	of	IN
cord-270337-92a5uwjf	28	9	positive	positive	JJ
cord-270337-92a5uwjf	28	10	inotropes	inotrope	NNS
cord-270337-92a5uwjf	28	11	in	in	IN
cord-270337-92a5uwjf	28	12	reducing	reduce	VBG
cord-270337-92a5uwjf	28	13	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	28	14	cardiotoxicity	cardiotoxicity	NN
cord-270337-92a5uwjf	28	15	.	.	.
cord-270337-92a5uwjf	29	1	LINKED	linked	JJ
cord-270337-92a5uwjf	29	2	ARTICLES	article	NNS
cord-270337-92a5uwjf	30	1	:	:	:
cord-270337-92a5uwjf	30	2	This	this	DT
cord-270337-92a5uwjf	30	3	article	article	NN
cord-270337-92a5uwjf	30	4	is	be	VBZ
cord-270337-92a5uwjf	30	5	part	part	NN
cord-270337-92a5uwjf	30	6	of	of	IN
cord-270337-92a5uwjf	30	7	a	a	DT
cord-270337-92a5uwjf	30	8	themed	themed	JJ
cord-270337-92a5uwjf	30	9	issue	issue	NN
cord-270337-92a5uwjf	30	10	on	on	IN
cord-270337-92a5uwjf	30	11	The	the	DT
cord-270337-92a5uwjf	30	12	Pharmacology	Pharmacology	NNP
cord-270337-92a5uwjf	30	13	of	of	IN
cord-270337-92a5uwjf	30	14	COVID‐19	COVID‐19	NNP
cord-270337-92a5uwjf	30	15	.	.	.
cord-270337-92a5uwjf	31	1	To	to	TO
cord-270337-92a5uwjf	31	2	view	view	VB
cord-270337-92a5uwjf	31	3	the	the	DT
cord-270337-92a5uwjf	31	4	other	other	JJ
cord-270337-92a5uwjf	31	5	articles	article	NNS
cord-270337-92a5uwjf	31	6	in	in	IN
cord-270337-92a5uwjf	31	7	this	this	DT
cord-270337-92a5uwjf	31	8	section	section	NN
cord-270337-92a5uwjf	31	9	visit	visit	NN
cord-270337-92a5uwjf	31	10	http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc	http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc	NNP
cord-270337-92a5uwjf	32	1	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	32	2	and	and	CC
cord-270337-92a5uwjf	32	3	hydroxychloroquine	hydroxychloroquine	NN
cord-270337-92a5uwjf	32	4	are	be	VBP
cord-270337-92a5uwjf	32	5	being	be	VBG
cord-270337-92a5uwjf	32	6	repurposed	repurpose	VBN
cord-270337-92a5uwjf	32	7	as	as	IN
cord-270337-92a5uwjf	32	8	potential	potential	JJ
cord-270337-92a5uwjf	32	9	treatments	treatment	NNS
cord-270337-92a5uwjf	32	10	for	for	IN
cord-270337-92a5uwjf	32	11	coronavirus	coronavirus	NN
cord-270337-92a5uwjf	32	12	disease	disease	NN
cord-270337-92a5uwjf	32	13	2019	2019	CD
cord-270337-92a5uwjf	33	1	(	(	-LRB-
cord-270337-92a5uwjf	33	2	Ferner	Ferner	NNP
cord-270337-92a5uwjf	33	3	&	&	CC
cord-270337-92a5uwjf	33	4	Aronson	Aronson	NNP
cord-270337-92a5uwjf	33	5	,	,	,
cord-270337-92a5uwjf	33	6	2020	2020	CD
cord-270337-92a5uwjf	33	7	)	)	-RRB-
cord-270337-92a5uwjf	33	8	.	.	.
cord-270337-92a5uwjf	34	1	The	the	DT
cord-270337-92a5uwjf	34	2	Food	Food	NNP
cord-270337-92a5uwjf	34	3	and	and	CC
cord-270337-92a5uwjf	34	4	Drug	Drug	NNP
cord-270337-92a5uwjf	34	5	Administration	Administration	NNP
cord-270337-92a5uwjf	34	6	(	(	-LRB-
cord-270337-92a5uwjf	34	7	FDA	FDA	NNP
cord-270337-92a5uwjf	34	8	,	,	,
cord-270337-92a5uwjf	34	9	2020	2020	CD
cord-270337-92a5uwjf	34	10	)	)	-RRB-
cord-270337-92a5uwjf	34	11	authorised	authorise	VBD
cord-270337-92a5uwjf	34	12	their	-PRON-	PRP$
cord-270337-92a5uwjf	34	13	emergency	emergency	NN
cord-270337-92a5uwjf	34	14	use	use	NN
cord-270337-92a5uwjf	34	15	in	in	IN
cord-270337-92a5uwjf	34	16	the	the	DT
cord-270337-92a5uwjf	34	17	United	United	NNP
cord-270337-92a5uwjf	34	18	States	States	NNP
cord-270337-92a5uwjf	34	19	and	and	CC
cord-270337-92a5uwjf	34	20	clinical	clinical	JJ
cord-270337-92a5uwjf	34	21	guidelines	guideline	NNS
cord-270337-92a5uwjf	34	22	in	in	IN
cord-270337-92a5uwjf	34	23	Belgium	Belgium	NNP
cord-270337-92a5uwjf	34	24	,	,	,
cord-270337-92a5uwjf	34	25	China	China	NNP
cord-270337-92a5uwjf	34	26	,	,	,
cord-270337-92a5uwjf	34	27	France	France	NNP
cord-270337-92a5uwjf	34	28	,	,	,
cord-270337-92a5uwjf	34	29	India	India	NNP
cord-270337-92a5uwjf	34	30	,	,	,
cord-270337-92a5uwjf	34	31	Iran	Iran	NNP
cord-270337-92a5uwjf	34	32	,	,	,
cord-270337-92a5uwjf	34	33	Italy	Italy	NNP
cord-270337-92a5uwjf	34	34	,	,	,
cord-270337-92a5uwjf	34	35	South	South	NNP
cord-270337-92a5uwjf	34	36	Korea	Korea	NNP
cord-270337-92a5uwjf	34	37	and	and	CC
cord-270337-92a5uwjf	34	38	The	the	DT
cord-270337-92a5uwjf	34	39	Netherlands	Netherlands	NNPS
cord-270337-92a5uwjf	34	40	have	have	VBP
cord-270337-92a5uwjf	34	41	made	make	VBN
cord-270337-92a5uwjf	34	42	recommendations	recommendation	NNS
cord-270337-92a5uwjf	34	43	for	for	IN
cord-270337-92a5uwjf	34	44	their	-PRON-	PRP$
cord-270337-92a5uwjf	34	45	use	use	NN
cord-270337-92a5uwjf	34	46	in	in	IN
cord-270337-92a5uwjf	34	47	the	the	DT
cord-270337-92a5uwjf	34	48	prevention	prevention	NN
cord-270337-92a5uwjf	34	49	and	and	CC
cord-270337-92a5uwjf	34	50	treatment	treatment	NN
cord-270337-92a5uwjf	34	51	of	of	IN
cord-270337-92a5uwjf	34	52	COVID-19	COVID-19	NNP
cord-270337-92a5uwjf	34	53	.	.	.
cord-270337-92a5uwjf	35	1	Case	case	NN
cord-270337-92a5uwjf	35	2	reports	report	NNS
cord-270337-92a5uwjf	35	3	of	of	IN
cord-270337-92a5uwjf	35	4	cardiotoxicity	cardiotoxicity	NN
cord-270337-92a5uwjf	35	5	and	and	CC
cord-270337-92a5uwjf	35	6	fatal	fatal	JJ
cord-270337-92a5uwjf	35	7	poisoning	poisoning	NN
cord-270337-92a5uwjf	35	8	relating	relate	VBG
cord-270337-92a5uwjf	35	9	to	to	IN
cord-270337-92a5uwjf	35	10	the	the	DT
cord-270337-92a5uwjf	35	11	use	use	NN
cord-270337-92a5uwjf	35	12	of	of	IN
cord-270337-92a5uwjf	35	13	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	35	14	and	and	CC
cord-270337-92a5uwjf	35	15	hydroxychloroquine	hydroxychloroquine	NN
cord-270337-92a5uwjf	35	16	for	for	IN
cord-270337-92a5uwjf	35	17	COVID-19	COVID-19	NNP
cord-270337-92a5uwjf	35	18	have	have	VBP
cord-270337-92a5uwjf	35	19	emerged	emerge	VBN
cord-270337-92a5uwjf	35	20	(	(	-LRB-
cord-270337-92a5uwjf	35	21	Agence	Agence	NNP
cord-270337-92a5uwjf	35	22	Régionale	Régionale	NNP
cord-270337-92a5uwjf	35	23	de	de	NNP
cord-270337-92a5uwjf	35	24	Santé	Santé	NNP
cord-270337-92a5uwjf	35	25	,	,	,
cord-270337-92a5uwjf	35	26	2020	2020	CD
cord-270337-92a5uwjf	35	27	;	;	:
cord-270337-92a5uwjf	35	28	Binding	binding	NN
cord-270337-92a5uwjf	35	29	,	,	,
cord-270337-92a5uwjf	35	30	2020	2020	CD
cord-270337-92a5uwjf	35	31	;	;	:
cord-270337-92a5uwjf	35	32	Busari	Busari	NNP
cord-270337-92a5uwjf	35	33	&	&	CC
cord-270337-92a5uwjf	35	34	Adebayo	Adebayo	NNP
cord-270337-92a5uwjf	35	35	,	,	,
cord-270337-92a5uwjf	35	36	2020	2020	CD
cord-270337-92a5uwjf	35	37	;	;	:
cord-270337-92a5uwjf	35	38	SimpliCity	SimpliCity	NNP
cord-270337-92a5uwjf	35	39	,	,	,
cord-270337-92a5uwjf	35	40	2020	2020	CD
cord-270337-92a5uwjf	35	41	;	;	:
cord-270337-92a5uwjf	35	42	Xuan	Xuan	NNP
cord-270337-92a5uwjf	35	43	,	,	,
cord-270337-92a5uwjf	35	44	2020	2020	CD
cord-270337-92a5uwjf	35	45	)	)	-RRB-
cord-270337-92a5uwjf	35	46	,	,	,
cord-270337-92a5uwjf	35	47	as	as	RB
cord-270337-92a5uwjf	35	48	well	well	RB
cord-270337-92a5uwjf	35	49	as	as	IN
cord-270337-92a5uwjf	35	50	excess	excess	JJ
cord-270337-92a5uwjf	35	51	death	death	NN
cord-270337-92a5uwjf	35	52	with	with	IN
cord-270337-92a5uwjf	35	53	high	high	JJ
cord-270337-92a5uwjf	35	54	doses	dose	NNS
cord-270337-92a5uwjf	35	55	in	in	IN
cord-270337-92a5uwjf	35	56	COVID-19	covid-19	JJ
cord-270337-92a5uwjf	35	57	clinical	clinical	JJ
cord-270337-92a5uwjf	35	58	trials	trial	NNS
cord-270337-92a5uwjf	36	1	(	(	-LRB-
cord-270337-92a5uwjf	36	2	Borba	Borba	NNP
cord-270337-92a5uwjf	36	3	et	et	NNP
cord-270337-92a5uwjf	36	4	al	al	NNP
cord-270337-92a5uwjf	36	5	.	.	NNP
cord-270337-92a5uwjf	36	6	,	,	,
cord-270337-92a5uwjf	36	7	2020	2020	CD
cord-270337-92a5uwjf	36	8	)	)	-RRB-
cord-270337-92a5uwjf	36	9	.	.	.
cord-270337-92a5uwjf	37	1	The	the	DT
cord-270337-92a5uwjf	37	2	acute	acute	JJ
cord-270337-92a5uwjf	37	3	toxic	toxic	JJ
cord-270337-92a5uwjf	37	4	effects	effect	NNS
cord-270337-92a5uwjf	37	5	of	of	IN
cord-270337-92a5uwjf	37	6	these	these	DT
cord-270337-92a5uwjf	37	7	drugs	drug	NNS
cord-270337-92a5uwjf	37	8	are	be	VBP
cord-270337-92a5uwjf	37	9	well	well	RB
cord-270337-92a5uwjf	37	10	recognised	recognise	VBN
cord-270337-92a5uwjf	37	11	(	(	-LRB-
cord-270337-92a5uwjf	37	12	World	World	NNP
cord-270337-92a5uwjf	37	13	Health	Health	NNP
cord-270337-92a5uwjf	37	14	Organization	Organization	NNP
cord-270337-92a5uwjf	37	15	,	,	,
cord-270337-92a5uwjf	37	16	2016	2016	CD
cord-270337-92a5uwjf	37	17	)	)	-RRB-
cord-270337-92a5uwjf	37	18	and	and	CC
cord-270337-92a5uwjf	37	19	relate	relate	VB
cord-270337-92a5uwjf	37	20	to	to	IN
cord-270337-92a5uwjf	37	21	their	-PRON-	PRP$
cord-270337-92a5uwjf	37	22	cardiotoxic	cardiotoxic	JJ
cord-270337-92a5uwjf	37	23	effects	effect	NNS
cord-270337-92a5uwjf	37	24	of	of	IN
cord-270337-92a5uwjf	37	25	widening	widen	VBG
cord-270337-92a5uwjf	37	26	of	of	IN
cord-270337-92a5uwjf	37	27	the	the	DT
cord-270337-92a5uwjf	37	28	QRS	qrs	NN
cord-270337-92a5uwjf	37	29	complex	complex	NN
cord-270337-92a5uwjf	37	30	,	,	,
cord-270337-92a5uwjf	37	31	atrioventricular	atrioventricular	JJ
cord-270337-92a5uwjf	37	32	block	block	NN
cord-270337-92a5uwjf	37	33	,	,	,
cord-270337-92a5uwjf	37	34	ventricular	ventricular	JJ
cord-270337-92a5uwjf	37	35	arrhythmias	arrhythmias	RB
cord-270337-92a5uwjf	37	36	,	,	,
cord-270337-92a5uwjf	37	37	negative	negative	JJ
cord-270337-92a5uwjf	37	38	inotropy	inotropy	NN
cord-270337-92a5uwjf	37	39	,	,	,
cord-270337-92a5uwjf	37	40	hypotension	hypotension	NN
cord-270337-92a5uwjf	37	41	and	and	CC
cord-270337-92a5uwjf	37	42	severe	severe	JJ
cord-270337-92a5uwjf	37	43	hypokalaemia	hypokalaemia	NN
cord-270337-92a5uwjf	37	44	,	,	,
cord-270337-92a5uwjf	37	45	which	which	WDT
cord-270337-92a5uwjf	37	46	occur	occur	VBP
cord-270337-92a5uwjf	37	47	within	within	IN
cord-270337-92a5uwjf	37	48	1	1	CD
cord-270337-92a5uwjf	37	49	-	-	SYM
cord-270337-92a5uwjf	37	50	3	3	CD
cord-270337-92a5uwjf	37	51	h	h	NN
cord-270337-92a5uwjf	37	52	of	of	IN
cord-270337-92a5uwjf	37	53	ingesting	ingest	VBG
cord-270337-92a5uwjf	37	54	doses	dose	NNS
cord-270337-92a5uwjf	37	55	>	>	XX
cord-270337-92a5uwjf	37	56	5	5	CD
cord-270337-92a5uwjf	37	57	g	g	NN
cord-270337-92a5uwjf	37	58	in	in	IN
cord-270337-92a5uwjf	37	59	adults	adult	NNS
cord-270337-92a5uwjf	37	60	.	.	.
cord-270337-92a5uwjf	38	1	Without	without	IN
cord-270337-92a5uwjf	38	2	intensive	intensive	JJ
cord-270337-92a5uwjf	38	3	,	,	,
cord-270337-92a5uwjf	38	4	supportive	supportive	JJ
cord-270337-92a5uwjf	38	5	treatment	treatment	NN
cord-270337-92a5uwjf	38	6	,	,	,
cord-270337-92a5uwjf	38	7	circulatory	circulatory	JJ
cord-270337-92a5uwjf	38	8	collapse	collapse	NN
cord-270337-92a5uwjf	38	9	and	and	CC
cord-270337-92a5uwjf	38	10	death	death	NN
cord-270337-92a5uwjf	38	11	can	can	MD
cord-270337-92a5uwjf	38	12	rapidly	rapidly	RB
cord-270337-92a5uwjf	38	13	follow	follow	VB
cord-270337-92a5uwjf	38	14	acute	acute	JJ
cord-270337-92a5uwjf	38	15	overdose	overdose	NN
cord-270337-92a5uwjf	38	16	.	.	.
cord-270337-92a5uwjf	39	1	Mortality	mortality	NN
cord-270337-92a5uwjf	39	2	due	due	IN
cord-270337-92a5uwjf	39	3	to	to	IN
cord-270337-92a5uwjf	39	4	acute	acute	JJ
cord-270337-92a5uwjf	39	5	toxicity	toxicity	NN
cord-270337-92a5uwjf	39	6	is	be	VBZ
cord-270337-92a5uwjf	39	7	high	high	JJ
cord-270337-92a5uwjf	39	8	,	,	,
cord-270337-92a5uwjf	39	9	with	with	IN
cord-270337-92a5uwjf	39	10	134	134	CD
cord-270337-92a5uwjf	39	11	of	of	IN
cord-270337-92a5uwjf	39	12	the	the	DT
cord-270337-92a5uwjf	39	13	387	387	CD
cord-270337-92a5uwjf	39	14	cases	case	NNS
cord-270337-92a5uwjf	39	15	reported	report	VBN
cord-270337-92a5uwjf	39	16	in	in	IN
cord-270337-92a5uwjf	39	17	the	the	DT
cord-270337-92a5uwjf	39	18	literature	literature	NN
cord-270337-92a5uwjf	39	19	between	between	IN
cord-270337-92a5uwjf	39	20	1955	1955	CD
cord-270337-92a5uwjf	39	21	and	and	CC
cord-270337-92a5uwjf	39	22	1975	1975	CD
cord-270337-92a5uwjf	39	23	(	(	-LRB-
cord-270337-92a5uwjf	39	24	Bondurand	Bondurand	NNP
cord-270337-92a5uwjf	39	25	,	,	,
cord-270337-92a5uwjf	39	26	N'Dri	N'Dri	NNP
cord-270337-92a5uwjf	39	27	,	,	,
cord-270337-92a5uwjf	39	28	Coffi	Coffi	NNP
cord-270337-92a5uwjf	39	29	,	,	,
cord-270337-92a5uwjf	39	30	&	&	CC
cord-270337-92a5uwjf	39	31	Saracino	Saracino	NNP
cord-270337-92a5uwjf	39	32	,	,	,
cord-270337-92a5uwjf	39	33	1980	1980	CD
cord-270337-92a5uwjf	39	34	,	,	,
cord-270337-92a5uwjf	39	35	and	and	CC
cord-270337-92a5uwjf	39	36	a	a	DT
cord-270337-92a5uwjf	39	37	further	further	JJ
cord-270337-92a5uwjf	39	38	135	135	CD
cord-270337-92a5uwjf	39	39	from	from	IN
cord-270337-92a5uwjf	39	40	335	335	CD
cord-270337-92a5uwjf	39	41	suicide	suicide	NN
cord-270337-92a5uwjf	39	42	attempts	attempt	NNS
cord-270337-92a5uwjf	39	43	(	(	-LRB-
cord-270337-92a5uwjf	39	44	Weniger	Weniger	NNP
cord-270337-92a5uwjf	39	45	and	and	CC
cord-270337-92a5uwjf	39	46	World	World	NNP
cord-270337-92a5uwjf	39	47	Health	Health	NNP
cord-270337-92a5uwjf	39	48	Organization	Organization	NNP
cord-270337-92a5uwjf	39	49	,	,	,
cord-270337-92a5uwjf	39	50	1979	1979	CD
cord-270337-92a5uwjf	39	51	)	)	-RRB-
cord-270337-92a5uwjf	39	52	resulting	result	VBG
cord-270337-92a5uwjf	39	53	in	in	IN
cord-270337-92a5uwjf	39	54	death	death	NN
cord-270337-92a5uwjf	39	55	.	.	.
cord-270337-92a5uwjf	40	1	Current	current	JJ
cord-270337-92a5uwjf	40	2	recommendations	recommendation	NNS
cord-270337-92a5uwjf	40	3	for	for	IN
cord-270337-92a5uwjf	40	4	the	the	DT
cord-270337-92a5uwjf	40	5	management	management	NN
cord-270337-92a5uwjf	40	6	of	of	IN
cord-270337-92a5uwjf	40	7	acute	acute	JJ
cord-270337-92a5uwjf	40	8	toxicity	toxicity	NN
cord-270337-92a5uwjf	40	9	include	include	VBP
cord-270337-92a5uwjf	40	10	ensuring	ensure	VBG
cord-270337-92a5uwjf	40	11	adequate	adequate	JJ
cord-270337-92a5uwjf	40	12	ventilation	ventilation	NN
cord-270337-92a5uwjf	40	13	,	,	,
cord-270337-92a5uwjf	40	14	gastric	gastric	JJ
cord-270337-92a5uwjf	40	15	lavage	lavage	NN
cord-270337-92a5uwjf	40	16	,	,	,
cord-270337-92a5uwjf	40	17	administration	administration	NN
cord-270337-92a5uwjf	40	18	of	of	IN
cord-270337-92a5uwjf	40	19	activated	activate	VBN
cord-270337-92a5uwjf	40	20	charcoal	charcoal	NN
cord-270337-92a5uwjf	40	21	,	,	,
cord-270337-92a5uwjf	40	22	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	40	23	for	for	IN
cord-270337-92a5uwjf	40	24	its	-PRON-	PRP$
cord-270337-92a5uwjf	40	25	inotropic	inotropic	NNP
cord-270337-92a5uwjf	40	26	and	and	CC
cord-270337-92a5uwjf	40	27	vasoconstrictor	vasoconstrictor	NN
cord-270337-92a5uwjf	40	28	effects	effect	NNS
cord-270337-92a5uwjf	40	29	,	,	,
cord-270337-92a5uwjf	40	30	diazepam	diazepam	NN
cord-270337-92a5uwjf	40	31	and	and	CC
cord-270337-92a5uwjf	40	32	correction	correction	NN
cord-270337-92a5uwjf	40	33	of	of	IN
cord-270337-92a5uwjf	40	34	metabolic	metabolic	JJ
cord-270337-92a5uwjf	40	35	acidosis	acidosis	NN
cord-270337-92a5uwjf	40	36	and	and	CC
cord-270337-92a5uwjf	40	37	hypokalaemia	hypokalaemia	NN
cord-270337-92a5uwjf	40	38	(	(	-LRB-
cord-270337-92a5uwjf	40	39	Jones	Jones	NNP
cord-270337-92a5uwjf	40	40	,	,	,
cord-270337-92a5uwjf	40	41	2015	2015	CD
cord-270337-92a5uwjf	40	42	)	)	-RRB-
cord-270337-92a5uwjf	40	43	.	.	.
cord-270337-92a5uwjf	41	1	The	the	DT
cord-270337-92a5uwjf	41	2	observation	observation	NN
cord-270337-92a5uwjf	41	3	in	in	IN
cord-270337-92a5uwjf	41	4	1976	1976	CD
cord-270337-92a5uwjf	41	5	of	of	IN
cord-270337-92a5uwjf	41	6	a	a	DT
cord-270337-92a5uwjf	41	7	patient	patient	NN
cord-270337-92a5uwjf	41	8	who	who	WP
cord-270337-92a5uwjf	41	9	took	take	VBD
cord-270337-92a5uwjf	41	10	5	5	CD
cord-270337-92a5uwjf	41	11	g	g	NN
cord-270337-92a5uwjf	41	12	of	of	IN
cord-270337-92a5uwjf	41	13	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	41	14	together	together	RB
cord-270337-92a5uwjf	41	15	with	with	IN
cord-270337-92a5uwjf	41	16	500	500	CD
cord-270337-92a5uwjf	41	17	mg	mg	NN
cord-270337-92a5uwjf	41	18	of	of	IN
cord-270337-92a5uwjf	41	19	diazepam	diazepam	NN
cord-270337-92a5uwjf	41	20	and	and	CC
cord-270337-92a5uwjf	41	21	survived	survive	VBD
cord-270337-92a5uwjf	41	22	without	without	IN
cord-270337-92a5uwjf	41	23	symptoms	symptom	NNS
cord-270337-92a5uwjf	41	24	of	of	IN
cord-270337-92a5uwjf	41	25	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	41	26	toxicity	toxicity	NN
cord-270337-92a5uwjf	41	27	(	(	-LRB-
cord-270337-92a5uwjf	41	28	Djelardje	Djelardje	NNP
cord-270337-92a5uwjf	41	29	,	,	,
cord-270337-92a5uwjf	41	30	1976	1976	CD
cord-270337-92a5uwjf	41	31	)	)	-RRB-
cord-270337-92a5uwjf	41	32	,	,	,
cord-270337-92a5uwjf	41	33	drew	draw	VBD
cord-270337-92a5uwjf	41	34	attention	attention	NN
cord-270337-92a5uwjf	41	35	to	to	IN
cord-270337-92a5uwjf	41	36	the	the	DT
cord-270337-92a5uwjf	41	37	possible	possible	JJ
cord-270337-92a5uwjf	41	38	role	role	NN
cord-270337-92a5uwjf	41	39	of	of	IN
cord-270337-92a5uwjf	41	40	diazepam	diazepam	NN
cord-270337-92a5uwjf	41	41	in	in	IN
cord-270337-92a5uwjf	41	42	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	41	43	poisoning	poisoning	NN
cord-270337-92a5uwjf	41	44	.	.	.
cord-270337-92a5uwjf	42	1	Subsequent	subsequent	JJ
cord-270337-92a5uwjf	42	2	case	case	NN
cord-270337-92a5uwjf	42	3	reports	report	VBZ
cord-270337-92a5uwjf	42	4	(	(	-LRB-
cord-270337-92a5uwjf	42	5	Jaeger	Jaeger	NNP
cord-270337-92a5uwjf	42	6	,	,	,
cord-270337-92a5uwjf	42	7	Sauder	Sauder	NNP
cord-270337-92a5uwjf	42	8	,	,	,
cord-270337-92a5uwjf	42	9	Kopferschmitt	Kopferschmitt	NNP
cord-270337-92a5uwjf	42	10	,	,	,
cord-270337-92a5uwjf	42	11	&	&	CC
cord-270337-92a5uwjf	42	12	Flesch	Flesch	NNP
cord-270337-92a5uwjf	42	13	,	,	,
cord-270337-92a5uwjf	42	14	1987	1987	CD
cord-270337-92a5uwjf	42	15	;	;	:
cord-270337-92a5uwjf	42	16	Meeran	Meeran	NNP
cord-270337-92a5uwjf	42	17	&	&	CC
cord-270337-92a5uwjf	42	18	Jacobs	Jacobs	NNP
cord-270337-92a5uwjf	42	19	,	,	,
cord-270337-92a5uwjf	42	20	1993	1993	CD
cord-270337-92a5uwjf	42	21	;	;	:
cord-270337-92a5uwjf	42	22	Rajah	Rajah	NNP
cord-270337-92a5uwjf	42	23	,	,	,
cord-270337-92a5uwjf	42	24	1990	1990	CD
cord-270337-92a5uwjf	42	25	)	)	-RRB-
cord-270337-92a5uwjf	42	26	and	and	CC
cord-270337-92a5uwjf	42	27	a	a	DT
cord-270337-92a5uwjf	42	28	prospective	prospective	JJ
cord-270337-92a5uwjf	42	29	non	non	JJ
cord-270337-92a5uwjf	42	30	-	-	JJ
cord-270337-92a5uwjf	42	31	randomised	randomised	JJ
cord-270337-92a5uwjf	42	32	trial	trial	NN
cord-270337-92a5uwjf	42	33	(	(	-LRB-
cord-270337-92a5uwjf	42	34	Riou	Riou	NNP
cord-270337-92a5uwjf	42	35	,	,	,
cord-270337-92a5uwjf	42	36	Barriot	Barriot	NNP
cord-270337-92a5uwjf	42	37	,	,	,
cord-270337-92a5uwjf	42	38	Rimailho	Rimailho	NNP
cord-270337-92a5uwjf	42	39	,	,	,
cord-270337-92a5uwjf	42	40	&	&	CC
cord-270337-92a5uwjf	42	41	Baud	Baud	NNP
cord-270337-92a5uwjf	42	42	,	,	,
cord-270337-92a5uwjf	42	43	1988	1988	CD
cord-270337-92a5uwjf	42	44	)	)	-RRB-
cord-270337-92a5uwjf	42	45	,	,	,
cord-270337-92a5uwjf	42	46	in	in	IN
cord-270337-92a5uwjf	42	47	which	which	WDT
cord-270337-92a5uwjf	42	48	the	the	DT
cord-270337-92a5uwjf	42	49	odds	odd	NNS
cord-270337-92a5uwjf	42	50	of	of	IN
cord-270337-92a5uwjf	42	51	survival	survival	NN
cord-270337-92a5uwjf	42	52	significantly	significantly	RB
cord-270337-92a5uwjf	42	53	favoured	favour	VBD
cord-270337-92a5uwjf	42	54	diazepam	diazepam	NN
cord-270337-92a5uwjf	42	55	therapy	therapy	NN
cord-270337-92a5uwjf	42	56	,	,	,
cord-270337-92a5uwjf	42	57	led	lead	VBD
cord-270337-92a5uwjf	42	58	to	to	IN
cord-270337-92a5uwjf	42	59	the	the	DT
cord-270337-92a5uwjf	42	60	recommendation	recommendation	NN
cord-270337-92a5uwjf	42	61	of	of	IN
cord-270337-92a5uwjf	42	62	diazepam	diazepam	NN
cord-270337-92a5uwjf	42	63	in	in	IN
cord-270337-92a5uwjf	42	64	the	the	DT
cord-270337-92a5uwjf	42	65	management	management	NN
cord-270337-92a5uwjf	42	66	of	of	IN
cord-270337-92a5uwjf	42	67	acute	acute	JJ
cord-270337-92a5uwjf	42	68	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	42	69	toxicity	toxicity	NN
cord-270337-92a5uwjf	42	70	.	.	.
cord-270337-92a5uwjf	43	1	However	however	RB
cord-270337-92a5uwjf	43	2	,	,	,
cord-270337-92a5uwjf	43	3	there	there	EX
cord-270337-92a5uwjf	43	4	remains	remain	VBZ
cord-270337-92a5uwjf	43	5	controversy	controversy	NN
cord-270337-92a5uwjf	43	6	given	give	VBN
cord-270337-92a5uwjf	43	7	some	some	DT
cord-270337-92a5uwjf	43	8	conflicting	conflicting	JJ
cord-270337-92a5uwjf	43	9	evidence	evidence	NN
cord-270337-92a5uwjf	43	10	of	of	IN
cord-270337-92a5uwjf	43	11	benefit	benefit	NN
cord-270337-92a5uwjf	43	12	(	(	-LRB-
cord-270337-92a5uwjf	43	13	Demaziere	Demaziere	NNP
cord-270337-92a5uwjf	43	14	et	et	FW
cord-270337-92a5uwjf	43	15	al	al	NNP
cord-270337-92a5uwjf	43	16	.	.	NNP
cord-270337-92a5uwjf	43	17	,	,	,
cord-270337-92a5uwjf	43	18	1992	1992	CD
cord-270337-92a5uwjf	43	19	;	;	.
cord-270337-92a5uwjf	44	1	Clemessy	Clemessy	NNP
cord-270337-92a5uwjf	44	2	et	et	FW
cord-270337-92a5uwjf	44	3	al	al	NNP
cord-270337-92a5uwjf	44	4	.	.	NNP
cord-270337-92a5uwjf	44	5	,	,	,
cord-270337-92a5uwjf	44	6	1996	1996	CD
cord-270337-92a5uwjf	44	7	)	)	-RRB-
cord-270337-92a5uwjf	44	8	and	and	CC
cord-270337-92a5uwjf	44	9	limitations	limitation	NNS
cord-270337-92a5uwjf	44	10	in	in	IN
cord-270337-92a5uwjf	44	11	study	study	NN
cord-270337-92a5uwjf	44	12	designs	design	NNS
cord-270337-92a5uwjf	44	13	(	(	-LRB-
cord-270337-92a5uwjf	44	14	Yanturali	Yanturali	NNP
cord-270337-92a5uwjf	44	15	,	,	,
cord-270337-92a5uwjf	44	16	2004	2004	CD
cord-270337-92a5uwjf	44	17	)	)	-RRB-
cord-270337-92a5uwjf	44	18	.	.	.
cord-270337-92a5uwjf	45	1	Experimental	experimental	JJ
cord-270337-92a5uwjf	45	2	toxicity	toxicity	NN
cord-270337-92a5uwjf	45	3	studies	study	NNS
cord-270337-92a5uwjf	45	4	are	be	VBP
cord-270337-92a5uwjf	45	5	also	also	RB
cord-270337-92a5uwjf	45	6	inconclusive	inconclusive	JJ
cord-270337-92a5uwjf	45	7	.	.	.
cord-270337-92a5uwjf	46	1	Crouzette	Crouzette	NNP
cord-270337-92a5uwjf	46	2	,	,	,
cord-270337-92a5uwjf	46	3	Vicaut	Vicaut	NNP
cord-270337-92a5uwjf	46	4	,	,	,
cord-270337-92a5uwjf	46	5	Palombo	Palombo	NNP
cord-270337-92a5uwjf	46	6	,	,	,
cord-270337-92a5uwjf	46	7	Girre	Girre	NNP
cord-270337-92a5uwjf	46	8	,	,	,
cord-270337-92a5uwjf	46	9	and	and	CC
cord-270337-92a5uwjf	46	10	Fournier	Fournier	NNP
cord-270337-92a5uwjf	46	11	(	(	-LRB-
cord-270337-92a5uwjf	46	12	1983	1983	CD
cord-270337-92a5uwjf	46	13	)	)	-RRB-
cord-270337-92a5uwjf	46	14	demonstrated	demonstrate	VBD
cord-270337-92a5uwjf	46	15	that	that	IN
cord-270337-92a5uwjf	46	16	an	an	DT
cord-270337-92a5uwjf	46	17	intraperitoneal	intraperitoneal	JJ
cord-270337-92a5uwjf	46	18	injection	injection	NN
cord-270337-92a5uwjf	46	19	of	of	IN
cord-270337-92a5uwjf	46	20	diazepam	diazepam	NN
cord-270337-92a5uwjf	46	21	caused	cause	VBD
cord-270337-92a5uwjf	46	22	a	a	DT
cord-270337-92a5uwjf	46	23	significant	significant	JJ
cord-270337-92a5uwjf	46	24	decrease	decrease	NN
cord-270337-92a5uwjf	46	25	in	in	IN
cord-270337-92a5uwjf	46	26	the	the	DT
cord-270337-92a5uwjf	46	27	mortality	mortality	NN
cord-270337-92a5uwjf	46	28	of	of	IN
cord-270337-92a5uwjf	46	29	rats	rat	NNS
cord-270337-92a5uwjf	46	30	treated	treat	VBN
cord-270337-92a5uwjf	46	31	with	with	IN
cord-270337-92a5uwjf	46	32	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	46	33	.	.	.
cord-270337-92a5uwjf	47	1	Riou	Riou	NNP
cord-270337-92a5uwjf	47	2	,	,	,
cord-270337-92a5uwjf	47	3	Rimailho	Rimailho	NNP
cord-270337-92a5uwjf	47	4	,	,	,
cord-270337-92a5uwjf	47	5	Galliot	Galliot	NNP
cord-270337-92a5uwjf	47	6	,	,	,
cord-270337-92a5uwjf	47	7	Bourdon	Bourdon	NNP
cord-270337-92a5uwjf	47	8	,	,	,
cord-270337-92a5uwjf	47	9	and	and	CC
cord-270337-92a5uwjf	47	10	Huet	Huet	NNP
cord-270337-92a5uwjf	47	11	(	(	-LRB-
cord-270337-92a5uwjf	47	12	1988	1988	CD
cord-270337-92a5uwjf	47	13	)	)	-RRB-
cord-270337-92a5uwjf	47	14	observed	observe	VBD
cord-270337-92a5uwjf	47	15	an	an	DT
cord-270337-92a5uwjf	47	16	improvement	improvement	NN
cord-270337-92a5uwjf	47	17	in	in	IN
cord-270337-92a5uwjf	47	18	haemodynamics	haemodynamic	NNS
cord-270337-92a5uwjf	47	19	and	and	CC
cord-270337-92a5uwjf	47	20	a	a	DT
cord-270337-92a5uwjf	47	21	correction	correction	NN
cord-270337-92a5uwjf	47	22	of	of	IN
cord-270337-92a5uwjf	47	23	the	the	DT
cord-270337-92a5uwjf	47	24	QRS	qrs	NN
cord-270337-92a5uwjf	47	25	interval	interval	NN
cord-270337-92a5uwjf	47	26	prolongation	prolongation	NN
cord-270337-92a5uwjf	47	27	when	when	WRB
cord-270337-92a5uwjf	47	28	diazepam	diazepam	NN
cord-270337-92a5uwjf	47	29	was	be	VBD
cord-270337-92a5uwjf	47	30	administered	administer	VBN
cord-270337-92a5uwjf	47	31	to	to	IN
cord-270337-92a5uwjf	47	32	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	47	33	-	-	HYPH
cord-270337-92a5uwjf	47	34	intoxicated	intoxicate	VBN
cord-270337-92a5uwjf	47	35	pigs	pig	NNS
cord-270337-92a5uwjf	47	36	.	.	.
cord-270337-92a5uwjf	48	1	Gnassounou	Gnassounou	NNP
cord-270337-92a5uwjf	48	2	and	and	CC
cord-270337-92a5uwjf	48	3	Advenier	Advenier	NNP
cord-270337-92a5uwjf	48	4	(	(	-LRB-
cord-270337-92a5uwjf	48	5	1988	1988	CD
cord-270337-92a5uwjf	48	6	)	)	-RRB-
cord-270337-92a5uwjf	48	7	observed	observe	VBD
cord-270337-92a5uwjf	48	8	that	that	IN
cord-270337-92a5uwjf	48	9	clonazepam	clonazepam	NN
cord-270337-92a5uwjf	48	10	protected	protect	VBD
cord-270337-92a5uwjf	48	11	anaesthetised	anaesthetised	JJ
cord-270337-92a5uwjf	48	12	rats	rat	NNS
cord-270337-92a5uwjf	48	13	against	against	IN
cord-270337-92a5uwjf	48	14	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	48	15	toxicity	toxicity	NN
cord-270337-92a5uwjf	48	16	and	and	CC
cord-270337-92a5uwjf	48	17	that	that	DT
cord-270337-92a5uwjf	48	18	diazepam	diazepam	NN
cord-270337-92a5uwjf	48	19	but	but	CC
cord-270337-92a5uwjf	48	20	not	not	RB
cord-270337-92a5uwjf	48	21	the	the	DT
cord-270337-92a5uwjf	48	22	translocator	translocator	NN
cord-270337-92a5uwjf	48	23	protein	protein	NN
cord-270337-92a5uwjf	48	24	(	(	-LRB-
cord-270337-92a5uwjf	48	25	TSPO	TSPO	NNP
cord-270337-92a5uwjf	48	26	)	)	-RRB-
cord-270337-92a5uwjf	48	27	agonist	agonist	NN
cord-270337-92a5uwjf	48	28	(	(	-LRB-
cord-270337-92a5uwjf	48	29	4	4	CD
cord-270337-92a5uwjf	48	30	0	0	CD
cord-270337-92a5uwjf	48	31	-chlorodiazepam	-chlorodiazepam	CD
cord-270337-92a5uwjf	48	32	)	)	-RRB-
cord-270337-92a5uwjf	48	33	protected	protect	VBN
cord-270337-92a5uwjf	48	34	against	against	IN
cord-270337-92a5uwjf	48	35	the	the	DT
cord-270337-92a5uwjf	48	36	decrease	decrease	NN
cord-270337-92a5uwjf	48	37	in	in	IN
cord-270337-92a5uwjf	48	38	contractions	contraction	NNS
cord-270337-92a5uwjf	48	39	,	,	.
cord-270337-92a5uwjf	49	1	observed	observe	VBN
cord-270337-92a5uwjf	49	2	when	when	WRB
cord-270337-92a5uwjf	49	3	guinea	guinea	NNP
cord-270337-92a5uwjf	49	4	pig	pig	NNP
cord-270337-92a5uwjf	49	5	atria	atria	NNP
cord-270337-92a5uwjf	49	6	were	be	VBD
cord-270337-92a5uwjf	49	7	exposed	expose	VBN
cord-270337-92a5uwjf	49	8	to	to	IN
cord-270337-92a5uwjf	49	9	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	49	10	.	.	.
cord-270337-92a5uwjf	50	1	In	in	IN
cord-270337-92a5uwjf	50	2	other	other	JJ
cord-270337-92a5uwjf	50	3	studies	study	NNS
cord-270337-92a5uwjf	50	4	,	,	,
cord-270337-92a5uwjf	50	5	however	however	RB
cord-270337-92a5uwjf	50	6	,	,	,
cord-270337-92a5uwjf	50	7	diazepam	diazepam	NNP
cord-270337-92a5uwjf	50	8	failed	fail	VBD
cord-270337-92a5uwjf	50	9	to	to	TO
cord-270337-92a5uwjf	50	10	improve	improve	VB
cord-270337-92a5uwjf	50	11	the	the	DT
cord-270337-92a5uwjf	50	12	mechanical	mechanical	JJ
cord-270337-92a5uwjf	50	13	performance	performance	NN
cord-270337-92a5uwjf	50	14	of	of	IN
cord-270337-92a5uwjf	50	15	rat	rat	NN
cord-270337-92a5uwjf	50	16	cardiac	cardiac	JJ
cord-270337-92a5uwjf	50	17	papillary	papillary	JJ
cord-270337-92a5uwjf	50	18	muscle	muscle	NN
cord-270337-92a5uwjf	50	19	exposed	expose	VBN
cord-270337-92a5uwjf	50	20	to	to	IN
cord-270337-92a5uwjf	50	21	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	50	22	(	(	-LRB-
cord-270337-92a5uwjf	50	23	Riou	Riou	NNP
cord-270337-92a5uwjf	50	24	,	,	,
cord-270337-92a5uwjf	50	25	Lecarpentier	Lecarpentier	NNP
cord-270337-92a5uwjf	50	26	,	,	,
cord-270337-92a5uwjf	50	27	Barriot	Barriot	NNP
cord-270337-92a5uwjf	50	28	,	,	,
cord-270337-92a5uwjf	50	29	&	&	CC
cord-270337-92a5uwjf	50	30	Viars	Viars	NNP
cord-270337-92a5uwjf	50	31	,	,	,
cord-270337-92a5uwjf	50	32	1989	1989	CD
cord-270337-92a5uwjf	50	33	)	)	-RRB-
cord-270337-92a5uwjf	50	34	and	and	CC
cord-270337-92a5uwjf	50	35	was	be	VBD
cord-270337-92a5uwjf	50	36	ineffective	ineffective	JJ
cord-270337-92a5uwjf	50	37	in	in	IN
cord-270337-92a5uwjf	50	38	reversing	reverse	VBG
cord-270337-92a5uwjf	50	39	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	50	40	toxicity	toxicity	NN
cord-270337-92a5uwjf	50	41	in	in	IN
cord-270337-92a5uwjf	50	42	anaesthetised	anaesthetised	JJ
cord-270337-92a5uwjf	50	43	rats	rat	NNS
cord-270337-92a5uwjf	50	44	(	(	-LRB-
cord-270337-92a5uwjf	50	45	Buckley	Buckley	NNP
cord-270337-92a5uwjf	50	46	,	,	,
cord-270337-92a5uwjf	50	47	Smith	Smith	NNP
cord-270337-92a5uwjf	50	48	,	,	,
cord-270337-92a5uwjf	50	49	Dosen	Dosen	NNP
cord-270337-92a5uwjf	50	50	,	,	,
cord-270337-92a5uwjf	50	51	&	&	CC
cord-270337-92a5uwjf	50	52	O'Connell	O'Connell	NNP
cord-270337-92a5uwjf	50	53	,	,	,
cord-270337-92a5uwjf	50	54	1996	1996	CD
cord-270337-92a5uwjf	50	55	)	)	-RRB-
cord-270337-92a5uwjf	50	56	.	.	.
cord-270337-92a5uwjf	51	1	It	-PRON-	PRP
cord-270337-92a5uwjf	51	2	would	would	MD
cord-270337-92a5uwjf	51	3	therefore	therefore	RB
cord-270337-92a5uwjf	51	4	appear	appear	VB
cord-270337-92a5uwjf	51	5	that	that	IN
cord-270337-92a5uwjf	51	6	the	the	DT
cord-270337-92a5uwjf	51	7	effectiveness	effectiveness	NN
cord-270337-92a5uwjf	51	8	of	of	IN
cord-270337-92a5uwjf	51	9	diazepam	diazepam	NN
cord-270337-92a5uwjf	51	10	in	in	IN
cord-270337-92a5uwjf	51	11	reversing	reverse	VBG
cord-270337-92a5uwjf	51	12	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	51	13	toxicity	toxicity	NN
cord-270337-92a5uwjf	51	14	is	be	VBZ
cord-270337-92a5uwjf	51	15	equivocal	equivocal	JJ
cord-270337-92a5uwjf	51	16	and	and	CC
cord-270337-92a5uwjf	51	17	that	that	IN
cord-270337-92a5uwjf	51	18	the	the	DT
cord-270337-92a5uwjf	51	19	mechanism(s	mechanism(s	NNP
cord-270337-92a5uwjf	51	20	)	)	-RRB-
cord-270337-92a5uwjf	51	21	by	by	IN
cord-270337-92a5uwjf	51	22	which	which	WDT
cord-270337-92a5uwjf	51	23	diazepam	diazepam	NNP
cord-270337-92a5uwjf	51	24	may	may	MD
cord-270337-92a5uwjf	51	25	exert	exert	VB
cord-270337-92a5uwjf	51	26	its	-PRON-	PRP$
cord-270337-92a5uwjf	51	27	effects	effect	NNS
cord-270337-92a5uwjf	51	28	remain	remain	VBP
cord-270337-92a5uwjf	51	29	unclear	unclear	JJ
cord-270337-92a5uwjf	51	30	.	.	.
cord-270337-92a5uwjf	52	1	Due	due	IN
cord-270337-92a5uwjf	52	2	to	to	IN
cord-270337-92a5uwjf	52	3	the	the	DT
cord-270337-92a5uwjf	52	4	resurgence	resurgence	NN
cord-270337-92a5uwjf	52	5	in	in	IN
cord-270337-92a5uwjf	52	6	the	the	DT
cord-270337-92a5uwjf	52	7	use	use	NN
cord-270337-92a5uwjf	52	8	of	of	IN
cord-270337-92a5uwjf	52	9	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	52	10	and	and	CC
cord-270337-92a5uwjf	52	11	its	-PRON-	PRP$
cord-270337-92a5uwjf	52	12	structural	structural	JJ
cord-270337-92a5uwjf	52	13	analogue	analogue	NN
cord-270337-92a5uwjf	52	14	hydroxychloroquine	hydroxychloroquine	NN
cord-270337-92a5uwjf	52	15	for	for	IN
cord-270337-92a5uwjf	52	16	COVID-19	COVID-19	NNP
cord-270337-92a5uwjf	52	17	,	,	,
cord-270337-92a5uwjf	52	18	the	the	DT
cord-270337-92a5uwjf	52	19	aim	aim	NN
cord-270337-92a5uwjf	52	20	of	of	IN
cord-270337-92a5uwjf	52	21	the	the	DT
cord-270337-92a5uwjf	52	22	present	present	JJ
cord-270337-92a5uwjf	52	23	study	study	NN
cord-270337-92a5uwjf	52	24	was	be	VBD
cord-270337-92a5uwjf	52	25	to	to	TO
cord-270337-92a5uwjf	52	26	investigate	investigate	VB
cord-270337-92a5uwjf	52	27	the	the	DT
cord-270337-92a5uwjf	52	28	potential	potential	JJ
cord-270337-92a5uwjf	52	29	cardioprotective	cardioprotective	JJ
cord-270337-92a5uwjf	52	30	effects	effect	NNS
cord-270337-92a5uwjf	52	31	of	of	IN
cord-270337-92a5uwjf	52	32	diazepam	diazepam	NN
cord-270337-92a5uwjf	52	33	in	in	IN
cord-270337-92a5uwjf	52	34	experimental	experimental	JJ
cord-270337-92a5uwjf	52	35	models	model	NNS
cord-270337-92a5uwjf	52	36	of	of	IN
cord-270337-92a5uwjf	52	37	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	52	38	toxicity	toxicity	NN
cord-270337-92a5uwjf	52	39	.	.	.
cord-270337-92a5uwjf	53	1	A	a	DT
cord-270337-92a5uwjf	53	2	series	series	NN
cord-270337-92a5uwjf	53	3	of	of	IN
cord-270337-92a5uwjf	53	4	experiments	experiment	NNS
cord-270337-92a5uwjf	53	5	was	be	VBD
cord-270337-92a5uwjf	53	6	conducted	conduct	VBN
cord-270337-92a5uwjf	53	7	to	to	TO
cord-270337-92a5uwjf	53	8	assess	assess	VB
cord-270337-92a5uwjf	53	9	the	the	DT
cord-270337-92a5uwjf	53	10	effects	effect	NNS
cord-270337-92a5uwjf	53	11	of	of	IN
cord-270337-92a5uwjf	53	12	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	53	13	and	and	CC
cord-270337-92a5uwjf	53	14	diazepam	diazepam	NN
cord-270337-92a5uwjf	53	15	alone	alone	RB
cord-270337-92a5uwjf	53	16	and	and	CC
cord-270337-92a5uwjf	53	17	in	in	IN
cord-270337-92a5uwjf	53	18	combination	combination	NN
cord-270337-92a5uwjf	53	19	on	on	IN
cord-270337-92a5uwjf	53	20	the	the	DT
cord-270337-92a5uwjf	53	21	contractility	contractility	NN
cord-270337-92a5uwjf	53	22	,	,	,
cord-270337-92a5uwjf	53	23	refractoriness	refractoriness	NN
cord-270337-92a5uwjf	53	24	and	and	CC
cord-270337-92a5uwjf	53	25	beating	beat	VBG
cord-270337-92a5uwjf	53	26	rate	rate	NN
cord-270337-92a5uwjf	53	27	of	of	IN
cord-270337-92a5uwjf	53	28	isolated	isolate	VBN
cord-270337-92a5uwjf	53	29	rat	rat	NN
cord-270337-92a5uwjf	53	30	cardiac	cardiac	NN
cord-270337-92a5uwjf	53	31	tissues	tissue	NNS
cord-270337-92a5uwjf	53	32	.	.	.
cord-270337-92a5uwjf	54	1	All	all	DT
cord-270337-92a5uwjf	54	2	animal	animal	NN
cord-270337-92a5uwjf	54	3	care	care	NN
cord-270337-92a5uwjf	54	4	and	and	CC
cord-270337-92a5uwjf	54	5	experimental	experimental	JJ
cord-270337-92a5uwjf	54	6	procedures	procedure	NNS
cord-270337-92a5uwjf	54	7	were	be	VBD
cord-270337-92a5uwjf	54	8	performed	perform	VBN
cord-270337-92a5uwjf	54	9	in	in	IN
cord-270337-92a5uwjf	54	10	accordance	accordance	NN
cord-270337-92a5uwjf	54	11	with	with	IN
cord-270337-92a5uwjf	54	12	the	the	DT
cord-270337-92a5uwjf	54	13	UK	UK	NNP
cord-270337-92a5uwjf	54	14	Animals	Animals	NNPS
cord-270337-92a5uwjf	54	15	(	(	-LRB-
cord-270337-92a5uwjf	54	16	Scientific	Scientific	NNP
cord-270337-92a5uwjf	54	17	Procedures	Procedures	NNPS
cord-270337-92a5uwjf	54	18	)	)	-RRB-
cord-270337-92a5uwjf	54	19	Act	Act	NNP
cord-270337-92a5uwjf	54	20	1986	1986	CD
cord-270337-92a5uwjf	54	21	,	,	,
cord-270337-92a5uwjf	54	22	approved	approve	VBN
cord-270337-92a5uwjf	54	23	by	by	IN
cord-270337-92a5uwjf	54	24	the	the	DT
cord-270337-92a5uwjf	54	25	institutional	institutional	JJ
cord-270337-92a5uwjf	54	26	ethical	ethical	JJ
cord-270337-92a5uwjf	54	27	review	review	NN
cord-270337-92a5uwjf	54	28	committee	committee	NN
cord-270337-92a5uwjf	54	29	,	,	,
cord-270337-92a5uwjf	54	30	and	and	CC
cord-270337-92a5uwjf	54	31	conducted	conduct	VBN
cord-270337-92a5uwjf	54	32	under	under	IN
cord-270337-92a5uwjf	54	33	the	the	DT
cord-270337-92a5uwjf	54	34	authority	authority	NN
cord-270337-92a5uwjf	54	35	of	of	IN
cord-270337-92a5uwjf	54	36	project	project	NN
cord-270337-92a5uwjf	54	37	licences	licence	NNS
cord-270337-92a5uwjf	54	38	held	hold	VBN
cord-270337-92a5uwjf	54	39	at	at	IN
cord-270337-92a5uwjf	54	40	the	the	DT
cord-270337-92a5uwjf	54	41	University	University	NNP
cord-270337-92a5uwjf	54	42	of	of	IN
cord-270337-92a5uwjf	54	43	Liverpool	Liverpool	NNP
cord-270337-92a5uwjf	54	44	.	.	.
cord-270337-92a5uwjf	55	1	Animal	animal	NN
cord-270337-92a5uwjf	55	2	studies	study	NNS
cord-270337-92a5uwjf	55	3	are	be	VBP
cord-270337-92a5uwjf	55	4	reported	report	VBN
cord-270337-92a5uwjf	55	5	in	in	IN
cord-270337-92a5uwjf	55	6	compliance	compliance	NN
cord-270337-92a5uwjf	55	7	with	with	IN
cord-270337-92a5uwjf	55	8	the	the	DT
cord-270337-92a5uwjf	55	9	ARRIVE	ARRIVE	NNP
cord-270337-92a5uwjf	55	10	guidelines	guideline	NNS
cord-270337-92a5uwjf	55	11	(	(	-LRB-
cord-270337-92a5uwjf	55	12	Kilkenny	Kilkenny	NNP
cord-270337-92a5uwjf	55	13	et	et	NNP
cord-270337-92a5uwjf	55	14	al	al	NNP
cord-270337-92a5uwjf	55	15	.	.	NNP
cord-270337-92a5uwjf	55	16	,	,	,
cord-270337-92a5uwjf	55	17	2010	2010	CD
cord-270337-92a5uwjf	55	18	;	;	:
cord-270337-92a5uwjf	55	19	McGrath	McGrath	NNP
cord-270337-92a5uwjf	55	20	,	,	,
cord-270337-92a5uwjf	55	21	McLachlan	McLachlan	NNP
cord-270337-92a5uwjf	55	22	,	,	,
cord-270337-92a5uwjf	55	23	&	&	CC
cord-270337-92a5uwjf	55	24	Zeller	Zeller	NNP
cord-270337-92a5uwjf	55	25	,	,	,
cord-270337-92a5uwjf	55	26	2015	2015	CD
cord-270337-92a5uwjf	55	27	)	)	-RRB-
cord-270337-92a5uwjf	55	28	and	and	CC
cord-270337-92a5uwjf	55	29	with	with	IN
cord-270337-92a5uwjf	55	30	the	the	DT
cord-270337-92a5uwjf	55	31	recommendations	recommendation	NNS
cord-270337-92a5uwjf	55	32	made	make	VBN
cord-270337-92a5uwjf	55	33	by	by	IN
cord-270337-92a5uwjf	55	34	the	the	DT
cord-270337-92a5uwjf	55	35	British	British	NNP
cord-270337-92a5uwjf	55	36	Journal	Journal	NNP
cord-270337-92a5uwjf	55	37	of	of	IN
cord-270337-92a5uwjf	55	38	Pharmacology	Pharmacology	NNP
cord-270337-92a5uwjf	55	39	.	.	.
cord-270337-92a5uwjf	56	1	•	•	NNP
cord-270337-92a5uwjf	57	1	Acute	acute	JJ
cord-270337-92a5uwjf	57	2	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	57	3	poisoning	poisoning	NN
cord-270337-92a5uwjf	57	4	manifests	manifest	VBZ
cord-270337-92a5uwjf	57	5	as	as	IN
cord-270337-92a5uwjf	57	6	cardiotoxicity	cardiotoxicity	NN
cord-270337-92a5uwjf	57	7	and	and	CC
cord-270337-92a5uwjf	57	8	is	be	VBZ
cord-270337-92a5uwjf	57	9	often	often	RB
cord-270337-92a5uwjf	57	10	managed	manage	VBN
cord-270337-92a5uwjf	57	11	using	use	VBG
cord-270337-92a5uwjf	57	12	diazepam	diazepam	NN
cord-270337-92a5uwjf	57	13	.	.	.
cord-270337-92a5uwjf	58	1	•	•	NNP
cord-270337-92a5uwjf	59	1	Diazepam	diazepam	NN
cord-270337-92a5uwjf	59	2	does	do	VBZ
cord-270337-92a5uwjf	59	3	not	not	RB
cord-270337-92a5uwjf	59	4	attenuate	attenuate	VB
cord-270337-92a5uwjf	59	5	the	the	DT
cord-270337-92a5uwjf	59	6	effects	effect	NNS
cord-270337-92a5uwjf	59	7	of	of	IN
cord-270337-92a5uwjf	59	8	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	59	9	in	in	IN
cord-270337-92a5uwjf	59	10	isolated	isolate	VBN
cord-270337-92a5uwjf	59	11	cardiac	cardiac	JJ
cord-270337-92a5uwjf	59	12	tissues	tissue	NNS
cord-270337-92a5uwjf	59	13	nor	nor	CC
cord-270337-92a5uwjf	59	14	in	in	IN
cord-270337-92a5uwjf	59	15	vivo	vivo	NNP
cord-270337-92a5uwjf	59	16	.	.	.
cord-270337-92a5uwjf	60	1	•	•	NNP
cord-270337-92a5uwjf	61	1	Inotropic	Inotropic	NNP
cord-270337-92a5uwjf	61	2	support	support	NN
cord-270337-92a5uwjf	61	3	,	,	,
cord-270337-92a5uwjf	61	4	which	which	WDT
cord-270337-92a5uwjf	61	5	is	be	VBZ
cord-270337-92a5uwjf	61	6	essential	essential	JJ
cord-270337-92a5uwjf	61	7	for	for	IN
cord-270337-92a5uwjf	61	8	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	61	9	poisoning	poisoning	NN
cord-270337-92a5uwjf	61	10	,	,	,
cord-270337-92a5uwjf	61	11	may	may	MD
cord-270337-92a5uwjf	61	12	be	be	VB
cord-270337-92a5uwjf	61	13	potentiated	potentiate	VBN
cord-270337-92a5uwjf	61	14	with	with	IN
cord-270337-92a5uwjf	61	15	diazepam	diazepam	NN
cord-270337-92a5uwjf	61	16	.	.	.
cord-270337-92a5uwjf	62	1	Male	male	JJ
cord-270337-92a5uwjf	62	2	Wistar	Wistar	NNP
cord-270337-92a5uwjf	62	3	rats	rat	NNS
cord-270337-92a5uwjf	62	4	were	be	VBD
cord-270337-92a5uwjf	62	5	bred	breed	VBN
cord-270337-92a5uwjf	62	6	in	in	IN
cord-270337-92a5uwjf	62	7	the	the	DT
cord-270337-92a5uwjf	62	8	departmental	departmental	JJ
cord-270337-92a5uwjf	62	9	animal	animal	NN
cord-270337-92a5uwjf	62	10	unit	unit	NN
cord-270337-92a5uwjf	62	11	(	(	-LRB-
cord-270337-92a5uwjf	62	12	the	the	DT
cord-270337-92a5uwjf	62	13	Nuffield	Nuffield	NNP
cord-270337-92a5uwjf	62	14	Joint	Joint	NNP
cord-270337-92a5uwjf	62	15	Facilities	Facilities	NNPS
cord-270337-92a5uwjf	62	16	)	)	-RRB-
cord-270337-92a5uwjf	62	17	or	or	CC
cord-270337-92a5uwjf	62	18	in	in	IN
cord-270337-92a5uwjf	62	19	exceptional	exceptional	JJ
cord-270337-92a5uwjf	62	20	circumstances	circumstance	NNS
cord-270337-92a5uwjf	62	21	of	of	IN
cord-270337-92a5uwjf	62	22	supply	supply	NN
cord-270337-92a5uwjf	62	23	shortage	shortage	NN
cord-270337-92a5uwjf	62	24	acquired	acquire	VBN
cord-270337-92a5uwjf	62	25	from	from	IN
cord-270337-92a5uwjf	62	26	the	the	DT
cord-270337-92a5uwjf	62	27	Biomedical	Biomedical	NNP
cord-270337-92a5uwjf	62	28	Services	Services	NNPS
cord-270337-92a5uwjf	62	29	Unit	Unit	NNP
cord-270337-92a5uwjf	62	30	,	,	,
cord-270337-92a5uwjf	62	31	Faculty	Faculty	NNP
cord-270337-92a5uwjf	62	32	of	of	IN
cord-270337-92a5uwjf	62	33	Medicine	Medicine	NNP
cord-270337-92a5uwjf	62	34	,	,	,
cord-270337-92a5uwjf	62	35	or	or	CC
cord-270337-92a5uwjf	62	36	the	the	DT
cord-270337-92a5uwjf	62	37	Department	Department	NNP
cord-270337-92a5uwjf	62	38	of	of	IN
cord-270337-92a5uwjf	62	39	Veterinary	Veterinary	NNP
cord-270337-92a5uwjf	62	40	Pathology	Pathology	NNP
cord-270337-92a5uwjf	62	41	,	,	,
cord-270337-92a5uwjf	62	42	University	University	NNP
cord-270337-92a5uwjf	62	43	of	of	IN
cord-270337-92a5uwjf	62	44	Liverpool	Liverpool	NNP
cord-270337-92a5uwjf	62	45	.	.	.
cord-270337-92a5uwjf	63	1	Rats	rat	NNS
cord-270337-92a5uwjf	63	2	were	be	VBD
cord-270337-92a5uwjf	63	3	kept	keep	VBN
cord-270337-92a5uwjf	63	4	under	under	IN
cord-270337-92a5uwjf	63	5	conditions	condition	NNS
cord-270337-92a5uwjf	63	6	of	of	IN
cord-270337-92a5uwjf	63	7	12-h	12-h	CD
cord-270337-92a5uwjf	63	8	light	light	JJ
cord-270337-92a5uwjf	63	9	/	/	SYM
cord-270337-92a5uwjf	63	10	dark	dark	JJ
cord-270337-92a5uwjf	63	11	cycle	cycle	NN
cord-270337-92a5uwjf	63	12	at	at	IN
cord-270337-92a5uwjf	63	13	20	20	CD
cord-270337-92a5uwjf	63	14	C	c	NN
cord-270337-92a5uwjf	63	15	with	with	IN
cord-270337-92a5uwjf	63	16	food	food	NN
cord-270337-92a5uwjf	63	17	(	(	-LRB-
cord-270337-92a5uwjf	63	18	CRM	CRM	NNP
cord-270337-92a5uwjf	63	19	diets	diet	NNS
cord-270337-92a5uwjf	63	20	,	,	,
cord-270337-92a5uwjf	63	21	SDS	SDS	NNP
cord-270337-92a5uwjf	63	22	,	,	,
cord-270337-92a5uwjf	63	23	Witham	Witham	NNP
cord-270337-92a5uwjf	63	24	,	,	,
cord-270337-92a5uwjf	63	25	Essex	Essex	NNP
cord-270337-92a5uwjf	63	26	)	)	-RRB-
cord-270337-92a5uwjf	63	27	and	and	CC
cord-270337-92a5uwjf	63	28	water	water	NN
cord-270337-92a5uwjf	63	29	available	available	JJ
cord-270337-92a5uwjf	63	30	ad	ad	NN
cord-270337-92a5uwjf	63	31	libitum	libitum	NN
cord-270337-92a5uwjf	63	32	.	.	.
cord-270337-92a5uwjf	64	1	The	the	DT
cord-270337-92a5uwjf	64	2	optimal	optimal	JJ
cord-270337-92a5uwjf	64	3	weight	weight	NN
cord-270337-92a5uwjf	64	4	range	range	NN
cord-270337-92a5uwjf	64	5	for	for	IN
cord-270337-92a5uwjf	64	6	experimental	experimental	JJ
cord-270337-92a5uwjf	64	7	use	use	NN
cord-270337-92a5uwjf	64	8	was	be	VBD
cord-270337-92a5uwjf	65	1	200	200	CD
cord-270337-92a5uwjf	65	2	-	-	SYM
cord-270337-92a5uwjf	65	3	400	400	CD
cord-270337-92a5uwjf	65	4	g.	g.	NNP
cord-270337-92a5uwjf	65	5	Rats	rat	NNS
cord-270337-92a5uwjf	65	6	were	be	VBD
cord-270337-92a5uwjf	65	7	administered	administer	VBN
cord-270337-92a5uwjf	65	8	1,000	1,000	CD
cord-270337-92a5uwjf	65	9	IUÁkg	IUÁkg	NNP
cord-270337-92a5uwjf	65	10	−1	−1	NNP
cord-270337-92a5uwjf	65	11	of	of	IN
cord-270337-92a5uwjf	65	12	sodium	sodium	NN
cord-270337-92a5uwjf	65	13	heparin	heparin	VBN
cord-270337-92a5uwjf	65	14	by	by	IN
cord-270337-92a5uwjf	65	15	an	an	DT
cord-270337-92a5uwjf	65	16	intraperitoneal	intraperitoneal	JJ
cord-270337-92a5uwjf	65	17	injection	injection	NN
cord-270337-92a5uwjf	65	18	.	.	.
cord-270337-92a5uwjf	66	1	After	after	IN
cord-270337-92a5uwjf	66	2	15	15	CD
cord-270337-92a5uwjf	66	3	min	min	NN
cord-270337-92a5uwjf	66	4	,	,	,
cord-270337-92a5uwjf	66	5	they	-PRON-	PRP
cord-270337-92a5uwjf	66	6	were	be	VBD
cord-270337-92a5uwjf	66	7	stunned	stun	VBN
cord-270337-92a5uwjf	66	8	by	by	IN
cord-270337-92a5uwjf	66	9	a	a	DT
cord-270337-92a5uwjf	66	10	blow	blow	NN
cord-270337-92a5uwjf	66	11	to	to	IN
cord-270337-92a5uwjf	66	12	the	the	DT
cord-270337-92a5uwjf	66	13	head	head	NN
cord-270337-92a5uwjf	66	14	,	,	,
cord-270337-92a5uwjf	66	15	exsanguinated	exsanguinate	VBN
cord-270337-92a5uwjf	66	16	and	and	CC
cord-270337-92a5uwjf	66	17	hearts	heart	NNS
cord-270337-92a5uwjf	66	18	were	be	VBD
cord-270337-92a5uwjf	66	19	excised	excise	VBN
cord-270337-92a5uwjf	66	20	.	.	.
cord-270337-92a5uwjf	67	1	Isolated	isolated	JJ
cord-270337-92a5uwjf	67	2	atria	atria	NN
cord-270337-92a5uwjf	67	3	,	,	,
cord-270337-92a5uwjf	67	4	ventricular	ventricular	JJ
cord-270337-92a5uwjf	67	5	strips	strip	NNS
cord-270337-92a5uwjf	67	6	(	(	-LRB-
cord-270337-92a5uwjf	67	7	≤2	≤2	NNP
cord-270337-92a5uwjf	67	8	mm	mm	NNP
cord-270337-92a5uwjf	67	9	in	in	IN
cord-270337-92a5uwjf	67	10	width	width	NN
cord-270337-92a5uwjf	67	11	)	)	-RRB-
cord-270337-92a5uwjf	67	12	dissected	dissect	VBN
cord-270337-92a5uwjf	67	13	longitudinally	longitudinally	RB
cord-270337-92a5uwjf	67	14	towards	towards	IN
cord-270337-92a5uwjf	67	15	the	the	DT
cord-270337-92a5uwjf	67	16	apex	apex	NN
cord-270337-92a5uwjf	67	17	of	of	IN
cord-270337-92a5uwjf	67	18	the	the	DT
cord-270337-92a5uwjf	67	19	heart	heart	NN
cord-270337-92a5uwjf	67	20	and	and	CC
cord-270337-92a5uwjf	67	21	right	right	JJ
cord-270337-92a5uwjf	67	22	papillary	papillary	JJ
cord-270337-92a5uwjf	67	23	muscles	muscle	NNS
cord-270337-92a5uwjf	67	24	were	be	VBD
cord-270337-92a5uwjf	67	25	prepared	prepare	VBN
cord-270337-92a5uwjf	67	26	and	and	CC
cord-270337-92a5uwjf	67	27	suspended	suspend	VBN
cord-270337-92a5uwjf	67	28	in	in	IN
cord-270337-92a5uwjf	67	29	30-ml	30-ml	CD
cord-270337-92a5uwjf	67	30	organ	organ	NN
cord-270337-92a5uwjf	67	31	baths	bath	NNS
cord-270337-92a5uwjf	67	32	,	,	,
cord-270337-92a5uwjf	67	33	containing	contain	VBG
cord-270337-92a5uwjf	67	34	(	(	-LRB-
cord-270337-92a5uwjf	67	35	in	in	IN
cord-270337-92a5uwjf	67	36	mM	mM	NNP
cord-270337-92a5uwjf	67	37	)	)	-RRB-
cord-270337-92a5uwjf	67	38	,	,	,
cord-270337-92a5uwjf	67	39	NaCl	NaCl	NNP
cord-270337-92a5uwjf	67	40	119	119	CD
cord-270337-92a5uwjf	67	41	;	;	:
cord-270337-92a5uwjf	67	42	KCI	KCI	NNP
cord-270337-92a5uwjf	67	43	3.8	3.8	CD
cord-270337-92a5uwjf	67	44	;	;	:
cord-270337-92a5uwjf	67	45	MgS0	MgS0	NNP
cord-270337-92a5uwjf	67	46	4	4	CD
cord-270337-92a5uwjf	67	47	1.18	1.18	CD
cord-270337-92a5uwjf	67	48	;	;	:
cord-270337-92a5uwjf	67	49	KH	KH	NNP
cord-270337-92a5uwjf	67	50	2	2	CD
cord-270337-92a5uwjf	67	51	PO	PO	NNP
cord-270337-92a5uwjf	67	52	4	4	CD
cord-270337-92a5uwjf	67	53	1.18	1.18	CD
cord-270337-92a5uwjf	67	54	;	;	:
cord-270337-92a5uwjf	67	55	NaHCO	nahco	JJ
cord-270337-92a5uwjf	67	56	3	3	CD
cord-270337-92a5uwjf	67	57	25	25	CD
cord-270337-92a5uwjf	67	58	;	;	:
cord-270337-92a5uwjf	67	59	CaCl	cacl	NN
cord-270337-92a5uwjf	67	60	2	2	CD
cord-270337-92a5uwjf	68	1	1.9	1.9	CD
cord-270337-92a5uwjf	68	2	plus	plus	CC
cord-270337-92a5uwjf	68	3	D	d	NN
cord-270337-92a5uwjf	68	4	-	-	HYPH
cord-270337-92a5uwjf	68	5	glucose	glucose	NN
cord-270337-92a5uwjf	68	6	10.0	10.0	CD
cord-270337-92a5uwjf	68	7	,	,	,
cord-270337-92a5uwjf	68	8	gassed	gas	VBN
cord-270337-92a5uwjf	68	9	with	with	IN
cord-270337-92a5uwjf	68	10	95	95	CD
cord-270337-92a5uwjf	68	11	%	%	NN
cord-270337-92a5uwjf	68	12	O	o	NN
cord-270337-92a5uwjf	68	13	2	2	CD
cord-270337-92a5uwjf	68	14	,	,	,
cord-270337-92a5uwjf	68	15	5	5	CD
cord-270337-92a5uwjf	68	16	%	%	NN
cord-270337-92a5uwjf	68	17	CO	co	NN
cord-270337-92a5uwjf	68	18	2	2	CD
cord-270337-92a5uwjf	68	19	(	(	-LRB-
cord-270337-92a5uwjf	68	20	BOC	BOC	NNP
cord-270337-92a5uwjf	68	21	medical	medical	JJ
cord-270337-92a5uwjf	68	22	gases	gas	NNS
cord-270337-92a5uwjf	68	23	,	,	,
cord-270337-92a5uwjf	68	24	Guildford	Guildford	NNP
cord-270337-92a5uwjf	68	25	)	)	-RRB-
cord-270337-92a5uwjf	68	26	and	and	CC
cord-270337-92a5uwjf	68	27	maintained	maintain	VBD
cord-270337-92a5uwjf	68	28	at	at	IN
cord-270337-92a5uwjf	68	29	37	37	CD
cord-270337-92a5uwjf	68	30	C.	c.	NN
cord-270337-92a5uwjf	69	1	Each	each	DT
cord-270337-92a5uwjf	69	2	preparation	preparation	NN
cord-270337-92a5uwjf	69	3	was	be	VBD
cord-270337-92a5uwjf	69	4	subjected	subject	VBN
cord-270337-92a5uwjf	69	5	to	to	IN
cord-270337-92a5uwjf	69	6	a	a	DT
cord-270337-92a5uwjf	69	7	resting	rest	VBG
cord-270337-92a5uwjf	69	8	diastolic	diastolic	JJ
cord-270337-92a5uwjf	69	9	tension	tension	NN
cord-270337-92a5uwjf	69	10	of	of	IN
cord-270337-92a5uwjf	69	11	10	10	CD
cord-270337-92a5uwjf	69	12	mN	mN	NNP
cord-270337-92a5uwjf	69	13	and	and	CC
cord-270337-92a5uwjf	69	14	stimulated	stimulate	VBD
cord-270337-92a5uwjf	69	15	with	with	IN
cord-270337-92a5uwjf	69	16	square	square	JJ
cord-270337-92a5uwjf	69	17	wave	wave	NN
cord-270337-92a5uwjf	69	18	pulses	pulse	NNS
cord-270337-92a5uwjf	69	19	of	of	IN
cord-270337-92a5uwjf	69	20	5-ms	5-ms	CD
cord-270337-92a5uwjf	69	21	duration	duration	NN
cord-270337-92a5uwjf	69	22	at	at	IN
cord-270337-92a5uwjf	69	23	a	a	DT
cord-270337-92a5uwjf	69	24	frequency	frequency	NN
cord-270337-92a5uwjf	69	25	of	of	IN
cord-270337-92a5uwjf	69	26	1	1	CD
cord-270337-92a5uwjf	69	27	Hz	Hz	NNP
cord-270337-92a5uwjf	69	28	via	via	IN
cord-270337-92a5uwjf	69	29	a	a	DT
cord-270337-92a5uwjf	69	30	Grass	Grass	NNP
cord-270337-92a5uwjf	69	31	S48	S48	NNP
cord-270337-92a5uwjf	69	32	or	or	CC
cord-270337-92a5uwjf	69	33	S88	S88	NNP
cord-270337-92a5uwjf	69	34	stimulator	stimulator	NN
cord-270337-92a5uwjf	69	35	(	(	-LRB-
cord-270337-92a5uwjf	69	36	Quincy	Quincy	NNP
cord-270337-92a5uwjf	69	37	,	,	,
cord-270337-92a5uwjf	69	38	Massachusetts	Massachusetts	NNP
cord-270337-92a5uwjf	69	39	)	)	-RRB-
cord-270337-92a5uwjf	69	40	.	.	.
cord-270337-92a5uwjf	70	1	Tissues	tissue	NNS
cord-270337-92a5uwjf	70	2	were	be	VBD
cord-270337-92a5uwjf	70	3	stimulated	stimulate	VBN
cord-270337-92a5uwjf	70	4	at	at	IN
cord-270337-92a5uwjf	70	5	twice	twice	RB
cord-270337-92a5uwjf	70	6	threshold	threshold	NN
cord-270337-92a5uwjf	70	7	voltage	voltage	NN
cord-270337-92a5uwjf	70	8	≤15	≤15	NNP
cord-270337-92a5uwjf	71	1	V.	V.	NNP
cord-270337-92a5uwjf	71	2	Right	Right	NNP
cord-270337-92a5uwjf	71	3	atria	atria	NN
cord-270337-92a5uwjf	71	4	were	be	VBD
cord-270337-92a5uwjf	71	5	allowed	allow	VBN
cord-270337-92a5uwjf	71	6	to	to	TO
cord-270337-92a5uwjf	71	7	equilibrate	equilibrate	VB
cord-270337-92a5uwjf	71	8	such	such	JJ
cord-270337-92a5uwjf	71	9	that	that	IN
cord-270337-92a5uwjf	71	10	spontaneous	spontaneous	JJ
cord-270337-92a5uwjf	71	11	,	,	,
cord-270337-92a5uwjf	71	12	rhythmic	rhythmic	JJ
cord-270337-92a5uwjf	71	13	beating	beating	NN
cord-270337-92a5uwjf	71	14	occurred	occur	VBD
cord-270337-92a5uwjf	71	15	.	.	.
cord-270337-92a5uwjf	72	1	In	in	IN
cord-270337-92a5uwjf	72	2	all	all	DT
cord-270337-92a5uwjf	72	3	cases	case	NNS
cord-270337-92a5uwjf	72	4	,	,	,
cord-270337-92a5uwjf	72	5	tissues	tissue	NNS
cord-270337-92a5uwjf	72	6	were	be	VBD
cord-270337-92a5uwjf	72	7	washed	wash	VBN
cord-270337-92a5uwjf	72	8	periodically	periodically	RB
cord-270337-92a5uwjf	72	9	throughout	throughout	IN
cord-270337-92a5uwjf	72	10	the	the	DT
cord-270337-92a5uwjf	72	11	stabilisation	stabilisation	NN
cord-270337-92a5uwjf	72	12	period	period	NN
cord-270337-92a5uwjf	72	13	.	.	.
cord-270337-92a5uwjf	73	1	Contractions	contraction	NNS
cord-270337-92a5uwjf	73	2	were	be	VBD
cord-270337-92a5uwjf	73	3	measured	measure	VBN
cord-270337-92a5uwjf	73	4	isometrically	isometrically	RB
cord-270337-92a5uwjf	73	5	via	via	IN
cord-270337-92a5uwjf	73	6	Dynamometer	Dynamometer	NNP
cord-270337-92a5uwjf	73	7	UF1	UF1	NNP
cord-270337-92a5uwjf	73	8	transducers	transducer	NNS
cord-270337-92a5uwjf	73	9	(	(	-LRB-
cord-270337-92a5uwjf	73	10	sensitivity	sensitivity	NN
cord-270337-92a5uwjf	73	11	range	range	NN
cord-270337-92a5uwjf	73	12	,	,	,
cord-270337-92a5uwjf	73	13	559	559	CD
cord-270337-92a5uwjf	73	14	mN	mN	NNP
cord-270337-92a5uwjf	73	15	)	)	-RRB-
cord-270337-92a5uwjf	73	16	connected	connect	VBD
cord-270337-92a5uwjf	73	17	to	to	IN
cord-270337-92a5uwjf	73	18	Lectromed	Lectromed	NNP
cord-270337-92a5uwjf	73	19	5230	5230	CD
cord-270337-92a5uwjf	73	20	preamplifiers	preamplifier	NNS
cord-270337-92a5uwjf	73	21	(	(	-LRB-
cord-270337-92a5uwjf	73	22	Letchworth	Letchworth	NNP
cord-270337-92a5uwjf	73	23	,	,	,
cord-270337-92a5uwjf	73	24	Hertfordshire	Hertfordshire	NNP
cord-270337-92a5uwjf	73	25	)	)	-RRB-
cord-270337-92a5uwjf	73	26	.	.	.
cord-270337-92a5uwjf	74	1	The	the	DT
cord-270337-92a5uwjf	74	2	beating	beat	VBG
cord-270337-92a5uwjf	74	3	rate	rate	NN
cord-270337-92a5uwjf	74	4	of	of	IN
cord-270337-92a5uwjf	74	5	right	right	JJ
cord-270337-92a5uwjf	74	6	atria	atria	NN
cord-270337-92a5uwjf	74	7	was	be	VBD
cord-270337-92a5uwjf	74	8	measured	measure	VBN
cord-270337-92a5uwjf	74	9	with	with	IN
cord-270337-92a5uwjf	74	10	a	a	DT
cord-270337-92a5uwjf	74	11	Lectromed	Lectromed	NNP
cord-270337-92a5uwjf	74	12	5250	5250	CD
cord-270337-92a5uwjf	74	13	ratemeter	ratemeter	NN
cord-270337-92a5uwjf	74	14	preamplifier	preamplifier	NN
cord-270337-92a5uwjf	74	15	.	.	.
cord-270337-92a5uwjf	75	1	These	these	DT
cord-270337-92a5uwjf	75	2	were	be	VBD
cord-270337-92a5uwjf	75	3	housed	house	VBN
cord-270337-92a5uwjf	75	4	within	within	IN
cord-270337-92a5uwjf	75	5	a	a	DT
cord-270337-92a5uwjf	75	6	MT8P	MT8P	NNP
cord-270337-92a5uwjf	75	7	preamplifier	preamplifier	NN
cord-270337-92a5uwjf	75	8	unit	unit	NN
cord-270337-92a5uwjf	75	9	,	,	,
cord-270337-92a5uwjf	75	10	which	which	WDT
cord-270337-92a5uwjf	75	11	relayed	relay	VBD
cord-270337-92a5uwjf	75	12	signals	signal	NNS
cord-270337-92a5uwjf	75	13	to	to	IN
cord-270337-92a5uwjf	75	14	a	a	DT
cord-270337-92a5uwjf	75	15	MT6	mt6	JJ
cord-270337-92a5uwjf	75	16	thermal	thermal	JJ
cord-270337-92a5uwjf	75	17	pen	pen	NN
cord-270337-92a5uwjf	75	18	recorder	recorder	NN
cord-270337-92a5uwjf	75	19	giving	give	VBG
cord-270337-92a5uwjf	75	20	an	an	DT
cord-270337-92a5uwjf	75	21	output	output	NN
cord-270337-92a5uwjf	75	22	on	on	IN
cord-270337-92a5uwjf	75	23	heatsensitive	heatsensitive	NNP
cord-270337-92a5uwjf	75	24	paper	paper	NN
cord-270337-92a5uwjf	75	25	.	.	.
cord-270337-92a5uwjf	76	1	Each	each	DT
cord-270337-92a5uwjf	76	2	channel	channel	NN
cord-270337-92a5uwjf	76	3	was	be	VBD
cord-270337-92a5uwjf	76	4	calibrated	calibrate	VBN
cord-270337-92a5uwjf	76	5	such	such	JJ
cord-270337-92a5uwjf	76	6	that	that	IN
cord-270337-92a5uwjf	76	7	a	a	DT
cord-270337-92a5uwjf	76	8	full	full	JJ
cord-270337-92a5uwjf	76	9	-	-	HYPH
cord-270337-92a5uwjf	76	10	scale	scale	NN
cord-270337-92a5uwjf	76	11	deflection	deflection	NN
cord-270337-92a5uwjf	76	12	of	of	IN
cord-270337-92a5uwjf	76	13	20	20	CD
cord-270337-92a5uwjf	76	14	mN	mN	NNP
cord-270337-92a5uwjf	76	15	could	could	MD
cord-270337-92a5uwjf	76	16	be	be	VB
cord-270337-92a5uwjf	76	17	observed	observe	VBN
cord-270337-92a5uwjf	76	18	.	.	.
cord-270337-92a5uwjf	77	1	Time	time	NN
cord-270337-92a5uwjf	77	2	to	to	TO
cord-270337-92a5uwjf	77	3	peak	peak	VB
cord-270337-92a5uwjf	77	4	tension	tension	NN
cord-270337-92a5uwjf	77	5	was	be	VBD
cord-270337-92a5uwjf	77	6	measured	measure	VBN
cord-270337-92a5uwjf	77	7	from	from	IN
cord-270337-92a5uwjf	77	8	the	the	DT
cord-270337-92a5uwjf	77	9	onset	onset	NN
cord-270337-92a5uwjf	77	10	of	of	IN
cord-270337-92a5uwjf	77	11	electrical	electrical	JJ
cord-270337-92a5uwjf	77	12	stimulation	stimulation	NN
cord-270337-92a5uwjf	77	13	to	to	IN
cord-270337-92a5uwjf	77	14	the	the	DT
cord-270337-92a5uwjf	77	15	peak	peak	NN
cord-270337-92a5uwjf	77	16	of	of	IN
cord-270337-92a5uwjf	77	17	the	the	DT
cord-270337-92a5uwjf	77	18	contraction	contraction	NN
cord-270337-92a5uwjf	77	19	(	(	-LRB-
cord-270337-92a5uwjf	77	20	Penefsky	Penefsky	NNP
cord-270337-92a5uwjf	77	21	,	,	,
cord-270337-92a5uwjf	77	22	1994	1994	CD
cord-270337-92a5uwjf	77	23	)	)	-RRB-
cord-270337-92a5uwjf	77	24	.	.	.
cord-270337-92a5uwjf	78	1	The	the	DT
cord-270337-92a5uwjf	78	2	effective	effective	JJ
cord-270337-92a5uwjf	78	3	refractory	refractory	JJ
cord-270337-92a5uwjf	78	4	periods	period	NNS
cord-270337-92a5uwjf	78	5	(	(	-LRB-
cord-270337-92a5uwjf	78	6	ERPs	ERPs	NNP
cord-270337-92a5uwjf	78	7	)	)	-RRB-
cord-270337-92a5uwjf	78	8	of	of	IN
cord-270337-92a5uwjf	78	9	left	leave	VBN
cord-270337-92a5uwjf	78	10	atria	atria	NN
cord-270337-92a5uwjf	78	11	,	,	,
cord-270337-92a5uwjf	78	12	right	right	JJ
cord-270337-92a5uwjf	78	13	papillary	papillary	JJ
cord-270337-92a5uwjf	78	14	muscles	muscle	NNS
cord-270337-92a5uwjf	78	15	and	and	CC
cord-270337-92a5uwjf	78	16	ventricular	ventricular	JJ
cord-270337-92a5uwjf	78	17	strips	strip	NNS
cord-270337-92a5uwjf	78	18	were	be	VBD
cord-270337-92a5uwjf	78	19	measured	measure	VBN
cord-270337-92a5uwjf	78	20	using	use	VBG
cord-270337-92a5uwjf	78	21	a	a	DT
cord-270337-92a5uwjf	78	22	modification	modification	NN
cord-270337-92a5uwjf	78	23	of	of	IN
cord-270337-92a5uwjf	78	24	the	the	DT
cord-270337-92a5uwjf	78	25	extra	extra	JJ
cord-270337-92a5uwjf	78	26	stimuli	stimulus	NNS
cord-270337-92a5uwjf	78	27	method	method	NN
cord-270337-92a5uwjf	78	28	(	(	-LRB-
cord-270337-92a5uwjf	78	29	Reuter	Reuter	NNP
cord-270337-92a5uwjf	78	30	&	&	CC
cord-270337-92a5uwjf	78	31	Heeg	Heeg	NNP
cord-270337-92a5uwjf	78	32	,	,	,
cord-270337-92a5uwjf	78	33	1971	1971	CD
cord-270337-92a5uwjf	78	34	)	)	-RRB-
cord-270337-92a5uwjf	78	35	.	.	.
cord-270337-92a5uwjf	79	1	A	a	DT
cord-270337-92a5uwjf	79	2	target	target	NN
cord-270337-92a5uwjf	79	3	of	of	IN
cord-270337-92a5uwjf	79	4	six	six	CD
cord-270337-92a5uwjf	79	5	samples	sample	NNS
cord-270337-92a5uwjf	79	6	of	of	IN
cord-270337-92a5uwjf	79	7	each	each	DT
cord-270337-92a5uwjf	79	8	cardiac	cardiac	JJ
cord-270337-92a5uwjf	79	9	tissue	tissue	NN
cord-270337-92a5uwjf	79	10	were	be	VBD
cord-270337-92a5uwjf	79	11	assigned	assign	VBN
cord-270337-92a5uwjf	79	12	at	at	IN
cord-270337-92a5uwjf	79	13	random	random	JJ
cord-270337-92a5uwjf	79	14	to	to	IN
cord-270337-92a5uwjf	79	15	one	one	CD
cord-270337-92a5uwjf	79	16	of	of	IN
cord-270337-92a5uwjf	79	17	four	four	CD
cord-270337-92a5uwjf	79	18	concentrations	concentration	NNS
cord-270337-92a5uwjf	79	19	of	of	IN
cord-270337-92a5uwjf	79	20	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	79	21	(	(	-LRB-
cord-270337-92a5uwjf	79	22	calculated	calculate	VBN
cord-270337-92a5uwjf	79	23	as	as	IN
cord-270337-92a5uwjf	79	24	the	the	DT
cord-270337-92a5uwjf	79	25	base	base	NN
cord-270337-92a5uwjf	79	26	;	;	:
cord-270337-92a5uwjf	79	27	1	1	CD
cord-270337-92a5uwjf	79	28	,	,	,
cord-270337-92a5uwjf	79	29	10	10	CD
cord-270337-92a5uwjf	79	30	,	,	,
cord-270337-92a5uwjf	79	31	30	30	CD
cord-270337-92a5uwjf	79	32	,	,	,
cord-270337-92a5uwjf	79	33	or	or	CC
cord-270337-92a5uwjf	79	34	100	100	CD
cord-270337-92a5uwjf	79	35	μM	μm	NN
cord-270337-92a5uwjf	79	36	,	,	,
cord-270337-92a5uwjf	79	37	dissolved	dissolve	VBN
cord-270337-92a5uwjf	79	38	in	in	IN
cord-270337-92a5uwjf	79	39	Krebs	Krebs	NNP
cord-270337-92a5uwjf	79	40	solution	solution	NN
cord-270337-92a5uwjf	79	41	)	)	-RRB-
cord-270337-92a5uwjf	79	42	in	in	IN
cord-270337-92a5uwjf	79	43	the	the	DT
cord-270337-92a5uwjf	79	44	presence	presence	NN
cord-270337-92a5uwjf	79	45	of	of	IN
cord-270337-92a5uwjf	79	46	the	the	DT
cord-270337-92a5uwjf	79	47	vehicle	vehicle	NN
cord-270337-92a5uwjf	79	48	for	for	IN
cord-270337-92a5uwjf	79	49	diazepam	diazepam	NN
cord-270337-92a5uwjf	79	50	(	(	-LRB-
cord-270337-92a5uwjf	79	51	1	1	CD
cord-270337-92a5uwjf	79	52	%	%	NN
cord-270337-92a5uwjf	79	53	v	v	NN
cord-270337-92a5uwjf	79	54	/	/	SYM
cord-270337-92a5uwjf	79	55	v	v	NN
cord-270337-92a5uwjf	79	56	propylene	propylene	NN
cord-270337-92a5uwjf	79	57	glycol	glycol	NN
cord-270337-92a5uwjf	79	58	)	)	-RRB-
cord-270337-92a5uwjf	79	59	.	.	.
cord-270337-92a5uwjf	80	1	Spontaneously	spontaneously	RB
cord-270337-92a5uwjf	80	2	beating	beat	VBG
cord-270337-92a5uwjf	80	3	right	right	JJ
cord-270337-92a5uwjf	80	4	atria	atria	NN
cord-270337-92a5uwjf	80	5	were	be	VBD
cord-270337-92a5uwjf	80	6	exposed	expose	VBN
cord-270337-92a5uwjf	80	7	only	only	RB
cord-270337-92a5uwjf	80	8	to	to	IN
cord-270337-92a5uwjf	80	9	30-μM	30-μm	CD
cord-270337-92a5uwjf	80	10	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	80	11	.	.	.
cord-270337-92a5uwjf	81	1	The	the	DT
cord-270337-92a5uwjf	81	2	highest	high	JJS
cord-270337-92a5uwjf	81	3	concentration	concentration	NN
cord-270337-92a5uwjf	81	4	of	of	IN
cord-270337-92a5uwjf	81	5	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	81	6	(	(	-LRB-
cord-270337-92a5uwjf	81	7	100	100	CD
cord-270337-92a5uwjf	81	8	μM	μM	NNP
cord-270337-92a5uwjf	81	9	)	)	-RRB-
cord-270337-92a5uwjf	81	10	decreased	decrease	VBD
cord-270337-92a5uwjf	81	11	the	the	DT
cord-270337-92a5uwjf	81	12	responsiveness	responsiveness	NN
cord-270337-92a5uwjf	81	13	of	of	IN
cord-270337-92a5uwjf	81	14	most	most	JJS
cord-270337-92a5uwjf	81	15	tissues	tissue	NNS
cord-270337-92a5uwjf	81	16	after	after	IN
cord-270337-92a5uwjf	81	17	approximately	approximately	RB
cord-270337-92a5uwjf	81	18	20	20	CD
cord-270337-92a5uwjf	81	19	to	to	TO
cord-270337-92a5uwjf	81	20	30	30	CD
cord-270337-92a5uwjf	81	21	min	min	NN
cord-270337-92a5uwjf	81	22	.	.	.
cord-270337-92a5uwjf	82	1	As	as	IN
cord-270337-92a5uwjf	82	2	the	the	DT
cord-270337-92a5uwjf	82	3	threshold	threshold	NN
cord-270337-92a5uwjf	82	4	voltage	voltage	NN
cord-270337-92a5uwjf	82	5	for	for	IN
cord-270337-92a5uwjf	82	6	contraction	contraction	NN
cord-270337-92a5uwjf	82	7	gradually	gradually	RB
cord-270337-92a5uwjf	82	8	increased	increase	VBN
cord-270337-92a5uwjf	82	9	,	,	,
cord-270337-92a5uwjf	82	10	tissues	tissue	NNS
cord-270337-92a5uwjf	82	11	failed	fail	VBD
cord-270337-92a5uwjf	82	12	to	to	TO
cord-270337-92a5uwjf	82	13	respond	respond	VB
cord-270337-92a5uwjf	82	14	to	to	IN
cord-270337-92a5uwjf	82	15	electrical	electrical	JJ
cord-270337-92a5uwjf	82	16	stimuli	stimulus	NNS
cord-270337-92a5uwjf	82	17	.	.	.
cord-270337-92a5uwjf	83	1	It	-PRON-	PRP
cord-270337-92a5uwjf	83	2	was	be	VBD
cord-270337-92a5uwjf	83	3	for	for	IN
cord-270337-92a5uwjf	83	4	this	this	DT
cord-270337-92a5uwjf	83	5	reason	reason	NN
cord-270337-92a5uwjf	83	6	that	that	DT
cord-270337-92a5uwjf	83	7	30	30	CD
cord-270337-92a5uwjf	83	8	μM	μm	NN
cord-270337-92a5uwjf	83	9	was	be	VBD
cord-270337-92a5uwjf	83	10	chosen	choose	VBN
cord-270337-92a5uwjf	83	11	for	for	IN
cord-270337-92a5uwjf	83	12	a	a	DT
cord-270337-92a5uwjf	83	13	subsequent	subsequent	JJ
cord-270337-92a5uwjf	83	14	experiment	experiment	NN
cord-270337-92a5uwjf	83	15	involving	involve	VBG
cord-270337-92a5uwjf	83	16	diazepam	diazepam	NN
cord-270337-92a5uwjf	83	17	.	.	.
cord-270337-92a5uwjf	84	1	In	in	IN
cord-270337-92a5uwjf	84	2	this	this	DT
cord-270337-92a5uwjf	84	3	second	second	JJ
cord-270337-92a5uwjf	84	4	experiment	experiment	NN
cord-270337-92a5uwjf	84	5	,	,	,
cord-270337-92a5uwjf	84	6	fresh	fresh	JJ
cord-270337-92a5uwjf	84	7	tissues	tissue	NNS
cord-270337-92a5uwjf	84	8	(	(	-LRB-
cord-270337-92a5uwjf	84	9	target	target	NN
cord-270337-92a5uwjf	84	10	of	of	IN
cord-270337-92a5uwjf	84	11	six	six	CD
cord-270337-92a5uwjf	84	12	per	per	IN
cord-270337-92a5uwjf	84	13	group	group	NN
cord-270337-92a5uwjf	84	14	)	)	-RRB-
cord-270337-92a5uwjf	84	15	were	be	VBD
cord-270337-92a5uwjf	84	16	incubated	incubate	VBN
cord-270337-92a5uwjf	84	17	with	with	IN
cord-270337-92a5uwjf	84	18	diazepam	diazepam	NN
cord-270337-92a5uwjf	84	19	at	at	IN
cord-270337-92a5uwjf	84	20	concentrations	concentration	NNS
cord-270337-92a5uwjf	84	21	of	of	IN
cord-270337-92a5uwjf	84	22	1	1	CD
cord-270337-92a5uwjf	84	23	,	,	,
cord-270337-92a5uwjf	84	24	10	10	CD
cord-270337-92a5uwjf	84	25	or	or	CC
cord-270337-92a5uwjf	84	26	100	100	CD
cord-270337-92a5uwjf	85	1	μM	μM	NNP
cord-270337-92a5uwjf	85	2	for	for	IN
cord-270337-92a5uwjf	86	1	30	30	CD
cord-270337-92a5uwjf	86	2	min	min	NN
cord-270337-92a5uwjf	86	3	before	before	IN
cord-270337-92a5uwjf	86	4	the	the	DT
cord-270337-92a5uwjf	86	5	addition	addition	NN
cord-270337-92a5uwjf	86	6	of	of	IN
cord-270337-92a5uwjf	86	7	30-μM	30-μm	CD
cord-270337-92a5uwjf	86	8	chloroquine	chloroquine	NNP
cord-270337-92a5uwjf	86	9	.	.	.
cord-270337-92a5uwjf	87	1	Experimental	experimental	JJ
cord-270337-92a5uwjf	87	2	models	model	NNS
cord-270337-92a5uwjf	87	3	of	of	IN
cord-270337-92a5uwjf	87	4	toxicity	toxicity	NN
cord-270337-92a5uwjf	87	5	were	be	VBD
cord-270337-92a5uwjf	87	6	developed	develop	VBN
cord-270337-92a5uwjf	87	7	in	in	IN
cord-270337-92a5uwjf	87	8	spontaneously	spontaneously	RB
cord-270337-92a5uwjf	87	9	breathing	breathe	VBG
cord-270337-92a5uwjf	87	10	rats	rat	NNS
cord-270337-92a5uwjf	87	11	,	,	,
cord-270337-92a5uwjf	87	12	ventilated	ventilate	VBN
cord-270337-92a5uwjf	87	13	rats	rat	NNS
cord-270337-92a5uwjf	87	14	and	and	CC
cord-270337-92a5uwjf	87	15	ventilated	ventilate	VBN
cord-270337-92a5uwjf	87	16	rabbits	rabbit	NNS
cord-270337-92a5uwjf	87	17	,	,	,
cord-270337-92a5uwjf	87	18	in	in	IN
cord-270337-92a5uwjf	87	19	which	which	WDT
cord-270337-92a5uwjf	87	20	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	87	21	was	be	VBD
cord-270337-92a5uwjf	87	22	infused	infuse	VBN
cord-270337-92a5uwjf	87	23	at	at	IN
cord-270337-92a5uwjf	87	24	different	different	JJ
cord-270337-92a5uwjf	87	25	rates	rate	NNS
cord-270337-92a5uwjf	87	26	and	and	CC
cord-270337-92a5uwjf	87	27	measurements	measurement	NNS
cord-270337-92a5uwjf	87	28	taken	take	VBN
cord-270337-92a5uwjf	87	29	of	of	IN
cord-270337-92a5uwjf	87	30	haemodynamic	haemodynamic	JJ
cord-270337-92a5uwjf	87	31	and	and	CC
cord-270337-92a5uwjf	87	32	electrocardiographic	electrocardiographic	JJ
cord-270337-92a5uwjf	87	33	parameters	parameter	NNS
cord-270337-92a5uwjf	87	34	.	.	.
cord-270337-92a5uwjf	88	1	Studies	study	NNS
cord-270337-92a5uwjf	88	2	were	be	VBD
cord-270337-92a5uwjf	88	3	then	then	RB
cord-270337-92a5uwjf	88	4	conducted	conduct	VBN
cord-270337-92a5uwjf	88	5	in	in	IN
cord-270337-92a5uwjf	88	6	which	which	WDT
cord-270337-92a5uwjf	88	7	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	88	8	-	-	HYPH
cord-270337-92a5uwjf	88	9	intoxicated	intoxicate	VBN
cord-270337-92a5uwjf	88	10	rats	rat	NNS
cord-270337-92a5uwjf	88	11	were	be	VBD
cord-270337-92a5uwjf	88	12	treated	treat	VBN
cord-270337-92a5uwjf	88	13	with	with	IN
cord-270337-92a5uwjf	88	14	combinations	combination	NNS
cord-270337-92a5uwjf	88	15	of	of	IN
cord-270337-92a5uwjf	88	16	diazepam	diazepam	NN
cord-270337-92a5uwjf	88	17	,	,	,
cord-270337-92a5uwjf	88	18	clonazepam	clonazepam	NN
cord-270337-92a5uwjf	88	19	,	,	,
cord-270337-92a5uwjf	88	20	Ro5	ro5	CD
cord-270337-92a5uwjf	88	21	-	-	HYPH
cord-270337-92a5uwjf	88	22	4864	4864	CD
cord-270337-92a5uwjf	88	23	,	,	,
cord-270337-92a5uwjf	88	24	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	88	25	or	or	CC
cord-270337-92a5uwjf	88	26	vehicle	vehicle	NN
cord-270337-92a5uwjf	88	27	control	control	NN
cord-270337-92a5uwjf	88	28	.	.	.
cord-270337-92a5uwjf	89	1	In	in	IN
cord-270337-92a5uwjf	89	2	developing	develop	VBG
cord-270337-92a5uwjf	89	3	a	a	DT
cord-270337-92a5uwjf	89	4	model	model	NN
cord-270337-92a5uwjf	89	5	of	of	IN
cord-270337-92a5uwjf	89	6	experimental	experimental	JJ
cord-270337-92a5uwjf	89	7	toxicity	toxicity	NN
cord-270337-92a5uwjf	89	8	,	,	,
cord-270337-92a5uwjf	89	9	animals	animal	NNS
cord-270337-92a5uwjf	89	10	(	(	-LRB-
cord-270337-92a5uwjf	89	11	six	six	CD
cord-270337-92a5uwjf	89	12	per	per	IN
cord-270337-92a5uwjf	89	13	group	group	NN
cord-270337-92a5uwjf	89	14	)	)	-RRB-
cord-270337-92a5uwjf	89	15	were	be	VBD
cord-270337-92a5uwjf	89	16	allocated	allocate	VBN
cord-270337-92a5uwjf	89	17	at	at	IN
cord-270337-92a5uwjf	89	18	random	random	JJ
cord-270337-92a5uwjf	89	19	to	to	IN
cord-270337-92a5uwjf	89	20	different	different	JJ
cord-270337-92a5uwjf	89	21	doses	dose	NNS
cord-270337-92a5uwjf	89	22	of	of	IN
cord-270337-92a5uwjf	89	23	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	89	24	diphosphate	diphosphate	NN
cord-270337-92a5uwjf	89	25	dissolved	dissolve	VBD
cord-270337-92a5uwjf	89	26	in	in	IN
cord-270337-92a5uwjf	89	27	0.9	0.9	CD
cord-270337-92a5uwjf	89	28	%	%	NN
cord-270337-92a5uwjf	89	29	w	w	NN
cord-270337-92a5uwjf	89	30	/	/	SYM
cord-270337-92a5uwjf	89	31	v	v	NN
cord-270337-92a5uwjf	89	32	NaCl	NaCl	NNP
cord-270337-92a5uwjf	89	33	.	.	.
cord-270337-92a5uwjf	90	1	Non	non	JJ
cord-270337-92a5uwjf	90	2	-	-	JJ
cord-270337-92a5uwjf	90	3	ventilated	ventilate	VBN
cord-270337-92a5uwjf	90	4	rats	rat	NNS
cord-270337-92a5uwjf	90	5	were	be	VBD
cord-270337-92a5uwjf	90	6	randomised	randomised	JJ
cord-270337-92a5uwjf	90	7	to	to	IN
cord-270337-92a5uwjf	90	8	intravenously	intravenously	RB
cord-270337-92a5uwjf	90	9	infused	infuse	VBN
cord-270337-92a5uwjf	90	10	doses	dose	NNS
cord-270337-92a5uwjf	90	11	(	(	-LRB-
cord-270337-92a5uwjf	90	12	calculated	calculate	VBN
cord-270337-92a5uwjf	90	13	as	as	IN
cord-270337-92a5uwjf	90	14	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	90	15	base	base	NN
cord-270337-92a5uwjf	90	16	)	)	-RRB-
cord-270337-92a5uwjf	90	17	of	of	IN
cord-270337-92a5uwjf	90	18	0.5	0.5	CD
cord-270337-92a5uwjf	90	19	,	,	,
cord-270337-92a5uwjf	90	20	1	1	CD
cord-270337-92a5uwjf	90	21	,	,	,
cord-270337-92a5uwjf	90	22	2	2	CD
cord-270337-92a5uwjf	90	23	or	or	CC
cord-270337-92a5uwjf	90	24	4	4	CD
cord-270337-92a5uwjf	90	25	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	90	26	−1	−1	NNP
cord-270337-92a5uwjf	90	27	Ámin	Ámin	NNP
cord-270337-92a5uwjf	90	28	−1	−1	NNP
cord-270337-92a5uwjf	90	29	,	,	,
cord-270337-92a5uwjf	90	30	ventilated	ventilate	VBD
cord-270337-92a5uwjf	90	31	rats	rat	NNS
cord-270337-92a5uwjf	90	32	1	1	CD
cord-270337-92a5uwjf	90	33	,	,	,
cord-270337-92a5uwjf	90	34	2	2	CD
cord-270337-92a5uwjf	90	35	or	or	CC
cord-270337-92a5uwjf	90	36	4	4	CD
cord-270337-92a5uwjf	90	37	mgÁkg	mgákg	NN
cord-270337-92a5uwjf	91	1	−1	−1	NNP
cord-270337-92a5uwjf	91	2	Ámin	Ámin	NNP
cord-270337-92a5uwjf	91	3	−1	−1	NNP
cord-270337-92a5uwjf	91	4	and	and	CC
cord-270337-92a5uwjf	91	5	rabbits	rabbit	VBZ
cord-270337-92a5uwjf	91	6	0.5	0.5	CD
cord-270337-92a5uwjf	91	7	,	,	,
cord-270337-92a5uwjf	91	8	1,or	1,or	CD
cord-270337-92a5uwjf	91	9	2	2	CD
cord-270337-92a5uwjf	91	10	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	91	11	−1	−1	NNP
cord-270337-92a5uwjf	91	12	Ámin	Ámin	NNP
cord-270337-92a5uwjf	91	13	−1	−1	NNP
cord-270337-92a5uwjf	91	14	for	for	IN
cord-270337-92a5uwjf	91	15	a	a	DT
cord-270337-92a5uwjf	91	16	maximum	maximum	JJ
cord-270337-92a5uwjf	91	17	period	period	NN
cord-270337-92a5uwjf	91	18	of	of	IN
cord-270337-92a5uwjf	91	19	60	60	CD
cord-270337-92a5uwjf	91	20	min	min	NN
cord-270337-92a5uwjf	91	21	or	or	CC
cord-270337-92a5uwjf	91	22	until	until	IN
cord-270337-92a5uwjf	91	23	death	death	NN
cord-270337-92a5uwjf	91	24	,	,	,
cord-270337-92a5uwjf	91	25	after	after	IN
cord-270337-92a5uwjf	91	26	an	an	DT
cord-270337-92a5uwjf	91	27	initial	initial	JJ
cord-270337-92a5uwjf	91	28	period	period	NN
cord-270337-92a5uwjf	91	29	of	of	IN
cord-270337-92a5uwjf	91	30	stabilisation	stabilisation	NN
cord-270337-92a5uwjf	91	31	of	of	IN
cord-270337-92a5uwjf	91	32	at	at	RB
cord-270337-92a5uwjf	91	33	least	least	RBS
cord-270337-92a5uwjf	91	34	20	20	CD
cord-270337-92a5uwjf	91	35	min	min	NN
cord-270337-92a5uwjf	91	36	.	.	.
cord-270337-92a5uwjf	92	1	Six	six	CD
cord-270337-92a5uwjf	92	2	treatment	treatment	NN
cord-270337-92a5uwjf	92	3	randomised	randomise	VBN
cord-270337-92a5uwjf	92	4	controlled	control	VBN
cord-270337-92a5uwjf	92	5	trials	trial	NNS
cord-270337-92a5uwjf	92	6	were	be	VBD
cord-270337-92a5uwjf	92	7	subsequently	subsequently	RB
cord-270337-92a5uwjf	92	8	conducted	conduct	VBN
cord-270337-92a5uwjf	92	9	to	to	TO
cord-270337-92a5uwjf	92	10	assess	assess	VB
cord-270337-92a5uwjf	92	11	the	the	DT
cord-270337-92a5uwjf	92	12	efficacy	efficacy	NN
cord-270337-92a5uwjf	92	13	of	of	IN
cord-270337-92a5uwjf	92	14	diazepam	diazepam	NN
cord-270337-92a5uwjf	92	15	,	,	,
cord-270337-92a5uwjf	92	16	clonazepam	clonazepam	NN
cord-270337-92a5uwjf	92	17	and	and	CC
cord-270337-92a5uwjf	92	18	Ro5	ro5	CD
cord-270337-92a5uwjf	92	19	-	-	HYPH
cord-270337-92a5uwjf	92	20	4864:-(i	4864:-(i	CD
cord-270337-92a5uwjf	92	21	)	)	-RRB-
cord-270337-92a5uwjf	93	1	prior	prior	RB
cord-270337-92a5uwjf	93	2	,	,	,
cord-270337-92a5uwjf	93	3	(	(	-LRB-
cord-270337-92a5uwjf	93	4	ii	ii	NN
cord-270337-92a5uwjf	93	5	)	)	-RRB-
cord-270337-92a5uwjf	93	6	during	during	IN
cord-270337-92a5uwjf	93	7	and	and	CC
cord-270337-92a5uwjf	93	8	(	(	-LRB-
cord-270337-92a5uwjf	93	9	iii	iii	NN
cord-270337-92a5uwjf	93	10	)	)	-RRB-
cord-270337-92a5uwjf	94	1	after	after	IN
cord-270337-92a5uwjf	94	2	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	94	3	intoxication	intoxication	NN
cord-270337-92a5uwjf	94	4	(	(	-LRB-
cord-270337-92a5uwjf	94	5	Table	Table	NNP
cord-270337-92a5uwjf	94	6	1	1	CD
cord-270337-92a5uwjf	94	7	)	)	-RRB-
cord-270337-92a5uwjf	94	8	and	and	CC
cord-270337-92a5uwjf	94	9	the	the	DT
cord-270337-92a5uwjf	94	10	effects	effect	NNS
cord-270337-92a5uwjf	94	11	of	of	IN
cord-270337-92a5uwjf	94	12	diazepam:-(iv	diazepam:-(iv	NNP
cord-270337-92a5uwjf	94	13	)	)	-RRB-
cord-270337-92a5uwjf	94	14	in	in	IN
cord-270337-92a5uwjf	94	15	high	high	JJ
cord-270337-92a5uwjf	94	16	dose	dose	NN
cord-270337-92a5uwjf	94	17	,	,	,
cord-270337-92a5uwjf	94	18	(	(	-LRB-
cord-270337-92a5uwjf	94	19	v	v	LS
cord-270337-92a5uwjf	94	20	)	)	-RRB-
cord-270337-92a5uwjf	94	21	in	in	IN
cord-270337-92a5uwjf	94	22	nonbarbiturate	nonbarbiturate	NNP
cord-270337-92a5uwjf	94	23	anaesthetised	anaesthetised	JJ
cord-270337-92a5uwjf	94	24	rats	rat	NNS
cord-270337-92a5uwjf	94	25	and	and	CC
cord-270337-92a5uwjf	94	26	(	(	-LRB-
cord-270337-92a5uwjf	94	27	vi	vi	NNP
cord-270337-92a5uwjf	94	28	)	)	-RRB-
cord-270337-92a5uwjf	94	29	co	co	NNS
cord-270337-92a5uwjf	94	30	-	-	VBN
cord-270337-92a5uwjf	94	31	administered	administer	VBN
cord-270337-92a5uwjf	94	32	with	with	IN
cord-270337-92a5uwjf	94	33	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	94	34	.	.	.
cord-270337-92a5uwjf	95	1	Six	six	CD
cord-270337-92a5uwjf	95	2	rats	rat	NNS
cord-270337-92a5uwjf	95	3	were	be	VBD
cord-270337-92a5uwjf	95	4	randomised	randomised	JJ
cord-270337-92a5uwjf	95	5	to	to	IN
cord-270337-92a5uwjf	95	6	each	each	DT
cord-270337-92a5uwjf	95	7	treatment	treatment	NN
cord-270337-92a5uwjf	95	8	group	group	NN
cord-270337-92a5uwjf	95	9	within	within	IN
cord-270337-92a5uwjf	95	10	each	each	DT
cord-270337-92a5uwjf	95	11	of	of	IN
cord-270337-92a5uwjf	95	12	these	these	DT
cord-270337-92a5uwjf	95	13	studies	study	NNS
cord-270337-92a5uwjf	95	14	.	.	.
cord-270337-92a5uwjf	96	1	Benzodiazepines	benzodiazepine	NNS
cord-270337-92a5uwjf	96	2	(	(	-LRB-
cord-270337-92a5uwjf	96	3	and	and	CC
cord-270337-92a5uwjf	96	4	vehicles	vehicle	NNS
cord-270337-92a5uwjf	96	5	)	)	-RRB-
cord-270337-92a5uwjf	96	6	were	be	VBD
cord-270337-92a5uwjf	96	7	administered	administer	VBN
cord-270337-92a5uwjf	96	8	as	as	IN
cord-270337-92a5uwjf	96	9	a	a	DT
cord-270337-92a5uwjf	96	10	slow	slow	JJ
cord-270337-92a5uwjf	96	11	intravenous	intravenous	JJ
cord-270337-92a5uwjf	96	12	bolus	bolus	NN
cord-270337-92a5uwjf	96	13	over	over	IN
cord-270337-92a5uwjf	96	14	2	2	CD
cord-270337-92a5uwjf	96	15	min	min	NN
cord-270337-92a5uwjf	96	16	.	.	.
cord-270337-92a5uwjf	97	1	Diazepam	Diazepam	NNP
cord-270337-92a5uwjf	97	2	was	be	VBD
cord-270337-92a5uwjf	97	3	administered	administer	VBN
cord-270337-92a5uwjf	97	4	in	in	IN
cord-270337-92a5uwjf	97	5	a	a	DT
cord-270337-92a5uwjf	97	6	2	2	CD
cord-270337-92a5uwjf	97	7	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	97	8	−1	−1	NNP
cord-270337-92a5uwjf	97	9	intravenous	intravenous	JJ
cord-270337-92a5uwjf	97	10	bolus	bolus	NN
cord-270337-92a5uwjf	97	11	dose	dose	NN
cord-270337-92a5uwjf	97	12	,	,	,
cord-270337-92a5uwjf	97	13	based	base	VBN
cord-270337-92a5uwjf	97	14	on	on	IN
cord-270337-92a5uwjf	97	15	and	and	CC
cord-270337-92a5uwjf	97	16	10	10	CD
cord-270337-92a5uwjf	97	17	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	97	18	−1	−1	NNP
cord-270337-92a5uwjf	97	19	in	in	IN
cord-270337-92a5uwjf	97	20	the	the	DT
cord-270337-92a5uwjf	97	21	study	study	NN
cord-270337-92a5uwjf	97	22	of	of	IN
cord-270337-92a5uwjf	97	23	high	high	JJ
cord-270337-92a5uwjf	97	24	dose	dose	NN
cord-270337-92a5uwjf	97	25	diazepam	diazepam	NN
cord-270337-92a5uwjf	97	26	,	,	,
cord-270337-92a5uwjf	97	27	which	which	WDT
cord-270337-92a5uwjf	97	28	approximates	approximate	VBZ
cord-270337-92a5uwjf	97	29	to	to	IN
cord-270337-92a5uwjf	97	30	the	the	DT
cord-270337-92a5uwjf	97	31	dose	dose	JJ
cord-270337-92a5uwjf	97	32	recommendations	recommendation	NNS
cord-270337-92a5uwjf	97	33	for	for	IN
cord-270337-92a5uwjf	97	34	human	human	JJ
cord-270337-92a5uwjf	97	35	cases	case	NNS
cord-270337-92a5uwjf	97	36	of	of	IN
cord-270337-92a5uwjf	97	37	overdose	overdose	NN
cord-270337-92a5uwjf	97	38	(	(	-LRB-
cord-270337-92a5uwjf	97	39	Jones	Jones	NNP
cord-270337-92a5uwjf	97	40	,	,	,
cord-270337-92a5uwjf	97	41	2015	2015	CD
cord-270337-92a5uwjf	97	42	)	)	-RRB-
cord-270337-92a5uwjf	97	43	when	when	WRB
cord-270337-92a5uwjf	97	44	scaled	scale	VBN
cord-270337-92a5uwjf	97	45	allometrically	allometrically	RB
cord-270337-92a5uwjf	97	46	(	(	-LRB-
cord-270337-92a5uwjf	97	47	Nair	Nair	NNP
cord-270337-92a5uwjf	97	48	&	&	CC
cord-270337-92a5uwjf	97	49	Jacob	Jacob	NNP
cord-270337-92a5uwjf	97	50	,	,	,
cord-270337-92a5uwjf	97	51	2016	2016	CD
cord-270337-92a5uwjf	97	52	)	)	-RRB-
cord-270337-92a5uwjf	97	53	.	.	.
cord-270337-92a5uwjf	98	1	The	the	DT
cord-270337-92a5uwjf	98	2	doses	dose	NNS
cord-270337-92a5uwjf	98	3	of	of	IN
cord-270337-92a5uwjf	98	4	clonazepam	clonazepam	NN
cord-270337-92a5uwjf	98	5	(	(	-LRB-
cord-270337-92a5uwjf	98	6	1.1	1.1	CD
cord-270337-92a5uwjf	98	7	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	98	8	−1	−1	NNP
cord-270337-92a5uwjf	98	9	)	)	-RRB-
cord-270337-92a5uwjf	98	10	and	and	CC
cord-270337-92a5uwjf	98	11	Ro5	ro5	CD
cord-270337-92a5uwjf	98	12	-	-	HYPH
cord-270337-92a5uwjf	98	13	4864	4864	CD
cord-270337-92a5uwjf	98	14	(	(	-LRB-
cord-270337-92a5uwjf	98	15	0.16	0.16	CD
cord-270337-92a5uwjf	98	16	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	98	17	−1	−1	NNP
cord-270337-92a5uwjf	98	18	)	)	-RRB-
cord-270337-92a5uwjf	98	19	were	be	VBD
cord-270337-92a5uwjf	98	20	chosen	choose	VBN
cord-270337-92a5uwjf	98	21	to	to	TO
cord-270337-92a5uwjf	98	22	have	have	VB
cord-270337-92a5uwjf	98	23	the	the	DT
cord-270337-92a5uwjf	98	24	equivalent	equivalent	JJ
cord-270337-92a5uwjf	98	25	GABAergic	gabaergic	NN
cord-270337-92a5uwjf	98	26	and	and	CC
cord-270337-92a5uwjf	98	27	non	non	JJ
cord-270337-92a5uwjf	98	28	-	-	JJ
cord-270337-92a5uwjf	98	29	GABAergic	gabaergic	JJ
cord-270337-92a5uwjf	98	30	activity	activity	NN
cord-270337-92a5uwjf	98	31	respectively	respectively	RB
cord-270337-92a5uwjf	98	32	,	,	,
cord-270337-92a5uwjf	98	33	to	to	IN
cord-270337-92a5uwjf	98	34	2	2	CD
cord-270337-92a5uwjf	98	35	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	98	36	−1	−1	NNP
cord-270337-92a5uwjf	98	37	of	of	IN
cord-270337-92a5uwjf	98	38	diazepam	diazepam	NNP
cord-270337-92a5uwjf	98	39	(	(	-LRB-
cord-270337-92a5uwjf	98	40	Wang	Wang	NNP
cord-270337-92a5uwjf	98	41	,	,	,
cord-270337-92a5uwjf	98	42	Taniguchi	Taniguchi	NNP
cord-270337-92a5uwjf	98	43	,	,	,
cord-270337-92a5uwjf	98	44	&	&	CC
cord-270337-92a5uwjf	98	45	Spector	Spector	NNP
cord-270337-92a5uwjf	98	46	,	,	,
cord-270337-92a5uwjf	98	47	1984	1984	CD
cord-270337-92a5uwjf	98	48	)	)	-RRB-
cord-270337-92a5uwjf	98	49	.	.	.
cord-270337-92a5uwjf	99	1	These	these	DT
cord-270337-92a5uwjf	99	2	approximate	approximate	JJ
cord-270337-92a5uwjf	99	3	to	to	IN
cord-270337-92a5uwjf	99	4	human	human	JJ
cord-270337-92a5uwjf	99	5	equivalent	equivalent	JJ
cord-270337-92a5uwjf	99	6	doses	dose	NNS
cord-270337-92a5uwjf	99	7	of	of	IN
cord-270337-92a5uwjf	99	8	0.18	0.18	CD
cord-270337-92a5uwjf	99	9	and	and	CC
cord-270337-92a5uwjf	99	10	0.03	0.03	CD
cord-270337-92a5uwjf	99	11	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	99	12	−1	−1	NNP
cord-270337-92a5uwjf	99	13	,	,	,
cord-270337-92a5uwjf	99	14	respectively	respectively	RB
cord-270337-92a5uwjf	99	15	.	.	.
cord-270337-92a5uwjf	100	1	The	the	DT
cord-270337-92a5uwjf	100	2	dose	dose	NN
cord-270337-92a5uwjf	100	3	of	of	IN
cord-270337-92a5uwjf	100	4	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	100	5	(	(	-LRB-
cord-270337-92a5uwjf	100	6	0.3	0.3	CD
cord-270337-92a5uwjf	100	7	μgÁkg	μgÁkg	NNP
cord-270337-92a5uwjf	100	8	−1	−1	NNP
cord-270337-92a5uwjf	100	9	Ámin	Ámin	NNP
cord-270337-92a5uwjf	100	10	−1	−1	NNP
cord-270337-92a5uwjf	100	11	)	)	-RRB-
cord-270337-92a5uwjf	100	12	was	be	VBD
cord-270337-92a5uwjf	100	13	chosen	choose	VBN
cord-270337-92a5uwjf	100	14	T	T	NNP
cord-270337-92a5uwjf	100	15	A	A	NNP
cord-270337-92a5uwjf	100	16	B	b	NN
cord-270337-92a5uwjf	100	17	L	l	NN
cord-270337-92a5uwjf	100	18	E	e	NN
cord-270337-92a5uwjf	100	19	1	1	CD
cord-270337-92a5uwjf	100	20	Experimental	experimental	JJ
cord-270337-92a5uwjf	100	21	protocols	protocol	NNS
cord-270337-92a5uwjf	100	22	for	for	IN
cord-270337-92a5uwjf	100	23	randomised	randomised	JJ
cord-270337-92a5uwjf	100	24	controlled	control	VBN
cord-270337-92a5uwjf	100	25	trials	trial	NNS
cord-270337-92a5uwjf	100	26	(	(	-LRB-
cord-270337-92a5uwjf	100	27	i	i	NN
cord-270337-92a5uwjf	100	28	)	)	-RRB-
cord-270337-92a5uwjf	100	29	to	to	IN
cord-270337-92a5uwjf	100	30	(	(	-LRB-
cord-270337-92a5uwjf	100	31	vi	vi	NNP
cord-270337-92a5uwjf	100	32	)	)	-RRB-
cord-270337-92a5uwjf	100	33	conducted	conduct	VBN
cord-270337-92a5uwjf	100	34	in	in	IN
cord-270337-92a5uwjf	100	35	anaesthetised	anaesthetised	JJ
cord-270337-92a5uwjf	100	36	rats	rat	NNS
cord-270337-92a5uwjf	100	37	to	to	TO
cord-270337-92a5uwjf	100	38	correspond	correspond	VB
cord-270337-92a5uwjf	100	39	to	to	IN
cord-270337-92a5uwjf	100	40	that	that	DT
cord-270337-92a5uwjf	100	41	which	which	WDT
cord-270337-92a5uwjf	100	42	produced	produce	VBD
cord-270337-92a5uwjf	100	43	50	50	CD
cord-270337-92a5uwjf	100	44	%	%	NN
cord-270337-92a5uwjf	100	45	increase	increase	NN
cord-270337-92a5uwjf	100	46	in	in	IN
cord-270337-92a5uwjf	100	47	maximum	maximum	JJ
cord-270337-92a5uwjf	100	48	rate	rate	NN
cord-270337-92a5uwjf	100	49	of	of	IN
cord-270337-92a5uwjf	100	50	left	left	JJ
cord-270337-92a5uwjf	100	51	ventricular	ventricular	JJ
cord-270337-92a5uwjf	100	52	pressure	pressure	NN
cord-270337-92a5uwjf	100	53	(	(	-LRB-
cord-270337-92a5uwjf	100	54	LV	LV	NNP
cord-270337-92a5uwjf	100	55	+	+	CC
cord-270337-92a5uwjf	100	56	dP	dP	NNP
cord-270337-92a5uwjf	100	57	/	/	SYM
cord-270337-92a5uwjf	100	58	dt	dt	NNP
cord-270337-92a5uwjf	100	59	max	max	NNP
cord-270337-92a5uwjf	100	60	)	)	-RRB-
cord-270337-92a5uwjf	100	61	in	in	IN
cord-270337-92a5uwjf	100	62	anaesthetised	anaesthetised	JJ
cord-270337-92a5uwjf	100	63	rats	rat	NNS
cord-270337-92a5uwjf	100	64	(	(	-LRB-
cord-270337-92a5uwjf	100	65	Latini	Latini	NNP
cord-270337-92a5uwjf	100	66	,	,	,
cord-270337-92a5uwjf	100	67	Zuanetti	Zuanetti	NNP
cord-270337-92a5uwjf	100	68	,	,	,
cord-270337-92a5uwjf	100	69	Conforti	Conforti	NNP
cord-270337-92a5uwjf	100	70	,	,	,
cord-270337-92a5uwjf	100	71	Schwartz	Schwartz	NNP
cord-270337-92a5uwjf	100	72	,	,	,
cord-270337-92a5uwjf	100	73	&	&	CC
cord-270337-92a5uwjf	100	74	Lazzara	Lazzara	NNP
cord-270337-92a5uwjf	100	75	,	,	,
cord-270337-92a5uwjf	100	76	1988	1988	CD
cord-270337-92a5uwjf	100	77	)	)	-RRB-
cord-270337-92a5uwjf	100	78	.	.	.
cord-270337-92a5uwjf	101	1	However	however	RB
cord-270337-92a5uwjf	101	2	,	,	,
cord-270337-92a5uwjf	101	3	this	this	DT
cord-270337-92a5uwjf	101	4	is	be	VBZ
cord-270337-92a5uwjf	101	5	appreciably	appreciably	RB
cord-270337-92a5uwjf	101	6	lower	low	JJR
cord-270337-92a5uwjf	101	7	(	(	-LRB-
cord-270337-92a5uwjf	101	8	allometrically	allometrically	RB
cord-270337-92a5uwjf	101	9	scaled	scale	VBN
cord-270337-92a5uwjf	101	10	human	human	JJ
cord-270337-92a5uwjf	101	11	equivalent	equivalent	JJ
cord-270337-92a5uwjf	101	12	dose	dose	NN
cord-270337-92a5uwjf	101	13	of	of	IN
cord-270337-92a5uwjf	101	14	0.05	0.05	CD
cord-270337-92a5uwjf	101	15	μgÁkg	μgÁkg	NNP
cord-270337-92a5uwjf	101	16	−1	−1	NNP
cord-270337-92a5uwjf	101	17	Ámin	Ámin	NNP
cord-270337-92a5uwjf	101	18	−1	−1	NNP
cord-270337-92a5uwjf	101	19	)	)	-RRB-
cord-270337-92a5uwjf	101	20	than	than	IN
cord-270337-92a5uwjf	101	21	infusion	infusion	NN
cord-270337-92a5uwjf	101	22	rates	rate	NNS
cord-270337-92a5uwjf	101	23	in	in	IN
cord-270337-92a5uwjf	101	24	human	human	JJ
cord-270337-92a5uwjf	101	25	poisoning	poisoning	NN
cord-270337-92a5uwjf	101	26	,	,	,
cord-270337-92a5uwjf	101	27	which	which	WDT
cord-270337-92a5uwjf	101	28	are	be	VBP
cord-270337-92a5uwjf	101	29	titrated	titrate	VBN
cord-270337-92a5uwjf	101	30	to	to	TO
cord-270337-92a5uwjf	101	31	maintain	maintain	VB
cord-270337-92a5uwjf	101	32	arterial	arterial	JJ
cord-270337-92a5uwjf	101	33	pressure	pressure	NN
cord-270337-92a5uwjf	101	34	(	(	-LRB-
cord-270337-92a5uwjf	101	35	median	median	JJ
cord-270337-92a5uwjf	101	36	maximal	maximal	JJ
cord-270337-92a5uwjf	101	37	rate	rate	NN
cord-270337-92a5uwjf	101	38	of	of	IN
cord-270337-92a5uwjf	101	39	0.7	0.7	CD
cord-270337-92a5uwjf	101	40	μgÁkg	μgÁkg	NNP
cord-270337-92a5uwjf	101	41	−1	−1	NNP
cord-270337-92a5uwjf	101	42	Ámin	Ámin	NNP
cord-270337-92a5uwjf	101	43	−1	−1	NNP
cord-270337-92a5uwjf	101	44	)	)	-RRB-
cord-270337-92a5uwjf	102	1	(	(	-LRB-
cord-270337-92a5uwjf	102	2	Mégarbane	Mégarbane	NNP
cord-270337-92a5uwjf	102	3	et	et	NNP
cord-270337-92a5uwjf	102	4	al	al	NNP
cord-270337-92a5uwjf	102	5	.	.	NNP
cord-270337-92a5uwjf	102	6	,	,	,
cord-270337-92a5uwjf	102	7	2010	2010	CD
cord-270337-92a5uwjf	102	8	)	)	-RRB-
cord-270337-92a5uwjf	102	9	.	.	.
cord-270337-92a5uwjf	103	1	Male	male	JJ
cord-270337-92a5uwjf	103	2	Wistar	Wistar	NNP
cord-270337-92a5uwjf	103	3	rats	rat	NNS
cord-270337-92a5uwjf	103	4	(	(	-LRB-
cord-270337-92a5uwjf	103	5	as	as	IN
cord-270337-92a5uwjf	103	6	above	above	JJ
cord-270337-92a5uwjf	103	7	)	)	-RRB-
cord-270337-92a5uwjf	103	8	and	and	CC
cord-270337-92a5uwjf	103	9	female	female	JJ
cord-270337-92a5uwjf	103	10	New	New	NNP
cord-270337-92a5uwjf	103	11	Zealand	Zealand	NNP
cord-270337-92a5uwjf	103	12	White	white	JJ
cord-270337-92a5uwjf	103	13	rabbits	rabbit	NNS
cord-270337-92a5uwjf	103	14	,	,	,
cord-270337-92a5uwjf	103	15	which	which	WDT
cord-270337-92a5uwjf	103	16	were	be	VBD
cord-270337-92a5uwjf	103	17	either	either	RB
cord-270337-92a5uwjf	103	18	bred	breed	VBN
cord-270337-92a5uwjf	103	19	in	in	IN
cord-270337-92a5uwjf	103	20	the	the	DT
cord-270337-92a5uwjf	103	21	departmental	departmental	JJ
cord-270337-92a5uwjf	103	22	animal	animal	NN
cord-270337-92a5uwjf	103	23	unit	unit	NN
cord-270337-92a5uwjf	103	24	or	or	CC
cord-270337-92a5uwjf	103	25	purchased	purchase	VBN
cord-270337-92a5uwjf	103	26	from	from	IN
cord-270337-92a5uwjf	103	27	Harlan	Harlan	NNP
cord-270337-92a5uwjf	103	28	Interfauna	Interfauna	NNP
cord-270337-92a5uwjf	103	29	(	(	-LRB-
cord-270337-92a5uwjf	103	30	Huntingdon	Huntingdon	NNP
cord-270337-92a5uwjf	103	31	,	,	,
cord-270337-92a5uwjf	103	32	Cambridgeshire	Cambridgeshire	NNP
cord-270337-92a5uwjf	103	33	)	)	-RRB-
cord-270337-92a5uwjf	103	34	,	,	,
cord-270337-92a5uwjf	103	35	were	be	VBD
cord-270337-92a5uwjf	103	36	used	use	VBN
cord-270337-92a5uwjf	103	37	.	.	.
cord-270337-92a5uwjf	104	1	Rabbits	rabbit	NNS
cord-270337-92a5uwjf	104	2	were	be	VBD
cord-270337-92a5uwjf	104	3	housed	house	VBN
cord-270337-92a5uwjf	104	4	under	under	IN
cord-270337-92a5uwjf	104	5	ambient	ambient	JJ
cord-270337-92a5uwjf	104	6	conditions	condition	NNS
cord-270337-92a5uwjf	104	7	of	of	IN
cord-270337-92a5uwjf	104	8	a	a	DT
cord-270337-92a5uwjf	104	9	12-h	12-h	CD
cord-270337-92a5uwjf	104	10	light	light	JJ
cord-270337-92a5uwjf	104	11	/	/	SYM
cord-270337-92a5uwjf	104	12	dark	dark	JJ
cord-270337-92a5uwjf	104	13	cycle	cycle	NN
cord-270337-92a5uwjf	104	14	at	at	IN
cord-270337-92a5uwjf	104	15	18	18	CD
cord-270337-92a5uwjf	104	16	C	c	NN
cord-270337-92a5uwjf	104	17	with	with	IN
cord-270337-92a5uwjf	104	18	food	food	NN
cord-270337-92a5uwjf	104	19	(	(	-LRB-
cord-270337-92a5uwjf	104	20	R14	R14	NNP
cord-270337-92a5uwjf	104	21	from	from	IN
cord-270337-92a5uwjf	104	22	SDS	SDS	NNP
cord-270337-92a5uwjf	104	23	,	,	,
cord-270337-92a5uwjf	104	24	Witham	Witham	NNP
cord-270337-92a5uwjf	104	25	,	,	,
cord-270337-92a5uwjf	104	26	Essex	Essex	NNP
cord-270337-92a5uwjf	104	27	)	)	-RRB-
cord-270337-92a5uwjf	104	28	and	and	CC
cord-270337-92a5uwjf	104	29	given	give	VBN
cord-270337-92a5uwjf	104	30	amprolium	amprolium	NN
cord-270337-92a5uwjf	104	31	HCI	HCI	NNP
cord-270337-92a5uwjf	104	32	7.68	7.68	CD
cord-270337-92a5uwjf	104	33	%	%	NN
cord-270337-92a5uwjf	104	34	w	w	NN
cord-270337-92a5uwjf	104	35	/	/	SYM
cord-270337-92a5uwjf	104	36	v	v	NN
cord-270337-92a5uwjf	104	37	and	and	CC
cord-270337-92a5uwjf	104	38	ethopabate	ethopabate	NNP
cord-270337-92a5uwjf	104	39	0.49	0.49	CD
cord-270337-92a5uwjf	104	40	%	%	NN
cord-270337-92a5uwjf	104	41	w	w	NN
cord-270337-92a5uwjf	104	42	/	/	SYM
cord-270337-92a5uwjf	104	43	v	v	NN
cord-270337-92a5uwjf	104	44	(	(	-LRB-
cord-270337-92a5uwjf	104	45	1.5	1.5	CD
cord-270337-92a5uwjf	104	46	ml	ml	NNS
cord-270337-92a5uwjf	104	47	per	per	IN
cord-270337-92a5uwjf	104	48	500	500	CD
cord-270337-92a5uwjf	104	49	ml	ml	NN
cord-270337-92a5uwjf	104	50	)	)	-RRB-
cord-270337-92a5uwjf	104	51	drinking	drinking	NN
cord-270337-92a5uwjf	104	52	water	water	NN
cord-270337-92a5uwjf	104	53	for	for	IN
cord-270337-92a5uwjf	104	54	5	5	CD
cord-270337-92a5uwjf	104	55	days	day	NNS
cord-270337-92a5uwjf	104	56	as	as	IN
cord-270337-92a5uwjf	104	57	a	a	DT
cord-270337-92a5uwjf	104	58	prophylaxis	prophylaxis	NN
cord-270337-92a5uwjf	104	59	against	against	IN
cord-270337-92a5uwjf	104	60	coccidiosis	coccidiosis	NN
cord-270337-92a5uwjf	104	61	infection	infection	NN
cord-270337-92a5uwjf	104	62	.	.	.
cord-270337-92a5uwjf	105	1	For	for	IN
cord-270337-92a5uwjf	105	2	rabbits	rabbit	NNS
cord-270337-92a5uwjf	105	3	,	,	,
cord-270337-92a5uwjf	105	4	the	the	DT
cord-270337-92a5uwjf	105	5	optimal	optimal	JJ
cord-270337-92a5uwjf	105	6	weight	weight	NN
cord-270337-92a5uwjf	105	7	range	range	NN
cord-270337-92a5uwjf	105	8	for	for	IN
cord-270337-92a5uwjf	105	9	experimental	experimental	JJ
cord-270337-92a5uwjf	105	10	use	use	NN
cord-270337-92a5uwjf	105	11	was	be	VBD
cord-270337-92a5uwjf	105	12	2	2	CD
cord-270337-92a5uwjf	105	13	-	-	SYM
cord-270337-92a5uwjf	105	14	3	3	CD
cord-270337-92a5uwjf	105	15	kg	kg	NN
cord-270337-92a5uwjf	105	16	.	.	.
cord-270337-92a5uwjf	106	1	Anaesthesia	Anaesthesia	NNP
cord-270337-92a5uwjf	106	2	was	be	VBD
cord-270337-92a5uwjf	106	3	induced	induce	VBN
cord-270337-92a5uwjf	106	4	in	in	IN
cord-270337-92a5uwjf	106	5	rats	rat	NNS
cord-270337-92a5uwjf	106	6	with	with	IN
cord-270337-92a5uwjf	106	7	sodium	sodium	NN
cord-270337-92a5uwjf	106	8	pentobarbitone	pentobarbitone	NN
cord-270337-92a5uwjf	106	9	of	of	IN
cord-270337-92a5uwjf	106	10	60	60	CD
cord-270337-92a5uwjf	106	11	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	106	12	−1	−1	NNP
cord-270337-92a5uwjf	106	13	intraperitoneally	intraperitoneally	NN
cord-270337-92a5uwjf	106	14	and	and	CC
cord-270337-92a5uwjf	106	15	,	,	,
cord-270337-92a5uwjf	106	16	once	once	RB
cord-270337-92a5uwjf	106	17	venous	venous	JJ
cord-270337-92a5uwjf	106	18	access	access	NN
cord-270337-92a5uwjf	106	19	was	be	VBD
cord-270337-92a5uwjf	106	20	established	establish	VBN
cord-270337-92a5uwjf	106	21	,	,	,
cord-270337-92a5uwjf	106	22	maintained	maintain	VBN
cord-270337-92a5uwjf	106	23	with	with	IN
cord-270337-92a5uwjf	106	24	intravenous	intravenous	JJ
cord-270337-92a5uwjf	106	25	boluses	bolus	NNS
cord-270337-92a5uwjf	106	26	of	of	IN
cord-270337-92a5uwjf	106	27	3	3	CD
cord-270337-92a5uwjf	106	28	mg	mg	NN
cord-270337-92a5uwjf	106	29	as	as	IN
cord-270337-92a5uwjf	106	30	required	require	VBN
cord-270337-92a5uwjf	106	31	.	.	.
cord-270337-92a5uwjf	107	1	In	in	IN
cord-270337-92a5uwjf	107	2	the	the	DT
cord-270337-92a5uwjf	107	3	treatment	treatment	NN
cord-270337-92a5uwjf	107	4	study	study	NN
cord-270337-92a5uwjf	107	5	(	(	-LRB-
cord-270337-92a5uwjf	107	6	v	v	NN
cord-270337-92a5uwjf	107	7	)	)	-RRB-
cord-270337-92a5uwjf	107	8	,	,	,
cord-270337-92a5uwjf	107	9	urethane	urethane	NN
cord-270337-92a5uwjf	107	10	was	be	VBD
cord-270337-92a5uwjf	107	11	prepared	prepare	VBN
cord-270337-92a5uwjf	107	12	as	as	IN
cord-270337-92a5uwjf	107	13	a	a	DT
cord-270337-92a5uwjf	107	14	15	15	CD
cord-270337-92a5uwjf	107	15	%	%	NN
cord-270337-92a5uwjf	107	16	w	w	NN
cord-270337-92a5uwjf	107	17	/	/	SYM
cord-270337-92a5uwjf	107	18	v	v	NN
cord-270337-92a5uwjf	107	19	solution	solution	NN
cord-270337-92a5uwjf	107	20	in	in	IN
cord-270337-92a5uwjf	107	21	isotonic	isotonic	JJ
cord-270337-92a5uwjf	107	22	saline	saline	NN
cord-270337-92a5uwjf	107	23	and	and	CC
cord-270337-92a5uwjf	107	24	administered	administer	VBN
cord-270337-92a5uwjf	107	25	as	as	IN
cord-270337-92a5uwjf	107	26	an	an	DT
cord-270337-92a5uwjf	107	27	intraperitoneal	intraperitoneal	JJ
cord-270337-92a5uwjf	107	28	dose	dose	NN
cord-270337-92a5uwjf	107	29	of	of	IN
cord-270337-92a5uwjf	107	30	1.4	1.4	CD
cord-270337-92a5uwjf	107	31	gÁkg	gÁkg	NNP
cord-270337-92a5uwjf	107	32	−1	−1	NNP
cord-270337-92a5uwjf	107	33	.	.	.
cord-270337-92a5uwjf	108	1	Neuroleptanalgesia	Neuroleptanalgesia	NNP
cord-270337-92a5uwjf	108	2	was	be	VBD
cord-270337-92a5uwjf	108	3	induced	induce	VBN
cord-270337-92a5uwjf	108	4	in	in	IN
cord-270337-92a5uwjf	108	5	rabbits	rabbit	NNS
cord-270337-92a5uwjf	108	6	by	by	IN
cord-270337-92a5uwjf	108	7	an	an	DT
cord-270337-92a5uwjf	108	8	intramuscular	intramuscular	JJ
cord-270337-92a5uwjf	108	9	injection	injection	NN
cord-270337-92a5uwjf	108	10	of	of	IN
cord-270337-92a5uwjf	108	11	0.5	0.5	CD
cord-270337-92a5uwjf	108	12	mlÁkg	mlÁkg	NNP
cord-270337-92a5uwjf	108	13	−1	−1	NNP
cord-270337-92a5uwjf	108	14	Hypnorm	Hypnorm	NNP
cord-270337-92a5uwjf	108	15	(	(	-LRB-
cord-270337-92a5uwjf	108	16	0.315	0.315	NFP
cord-270337-92a5uwjf	108	17	mgÁml	mgÁml	NNP
cord-270337-92a5uwjf	108	18	−1	−1	NNP
cord-270337-92a5uwjf	108	19	fentanyl	fentanyl	NN
cord-270337-92a5uwjf	108	20	citrate	citrate	NN
cord-270337-92a5uwjf	108	21	and	and	CC
cord-270337-92a5uwjf	108	22	10	10	CD
cord-270337-92a5uwjf	108	23	mgÁml	mgÁml	NNP
cord-270337-92a5uwjf	108	24	−1	−1	NNP
cord-270337-92a5uwjf	108	25	fluanisone	fluanisone	NNP
cord-270337-92a5uwjf	108	26	)	)	-RRB-
cord-270337-92a5uwjf	108	27	.	.	.
cord-270337-92a5uwjf	109	1	Surgical	surgical	JJ
cord-270337-92a5uwjf	109	2	anaesthesia	anaesthesia	NN
cord-270337-92a5uwjf	109	3	was	be	VBD
cord-270337-92a5uwjf	109	4	achieved	achieve	VBN
cord-270337-92a5uwjf	109	5	by	by	IN
cord-270337-92a5uwjf	109	6	administering	administer	VBG
cord-270337-92a5uwjf	109	7	sequential	sequential	JJ
cord-270337-92a5uwjf	109	8	4-mg	4-mg	CD
cord-270337-92a5uwjf	109	9	boluses	bolus	NNS
cord-270337-92a5uwjf	109	10	of	of	IN
cord-270337-92a5uwjf	109	11	sodium	sodium	NN
cord-270337-92a5uwjf	109	12	pentobarbitone	pentobarbitone	NN
cord-270337-92a5uwjf	109	13	into	into	IN
cord-270337-92a5uwjf	109	14	the	the	DT
cord-270337-92a5uwjf	109	15	marginal	marginal	JJ
cord-270337-92a5uwjf	109	16	ear	ear	NN
cord-270337-92a5uwjf	109	17	vein	vein	NN
cord-270337-92a5uwjf	109	18	and	and	CC
cord-270337-92a5uwjf	109	19	then	then	RB
cord-270337-92a5uwjf	109	20	12-mg	12-mg	CD
cord-270337-92a5uwjf	109	21	boluses	bolus	NNS
cord-270337-92a5uwjf	109	22	via	via	IN
cord-270337-92a5uwjf	109	23	a	a	DT
cord-270337-92a5uwjf	109	24	cannulated	cannulate	VBN
cord-270337-92a5uwjf	109	25	femoral	femoral	JJ
cord-270337-92a5uwjf	109	26	vein	vein	NN
cord-270337-92a5uwjf	109	27	,	,	,
cord-270337-92a5uwjf	109	28	as	as	IN
cord-270337-92a5uwjf	109	29	required	require	VBN
cord-270337-92a5uwjf	109	30	,	,	,
cord-270337-92a5uwjf	109	31	upon	upon	IN
cord-270337-92a5uwjf	109	32	commencement	commencement	NN
cord-270337-92a5uwjf	109	33	of	of	IN
cord-270337-92a5uwjf	109	34	ventilation	ventilation	NN
cord-270337-92a5uwjf	109	35	.	.	.
cord-270337-92a5uwjf	110	1	Femoral	femoral	JJ
cord-270337-92a5uwjf	110	2	veins	vein	NNS
cord-270337-92a5uwjf	110	3	were	be	VBD
cord-270337-92a5uwjf	110	4	cannulated	cannulate	VBN
cord-270337-92a5uwjf	110	5	for	for	IN
cord-270337-92a5uwjf	110	6	venous	venous	JJ
cord-270337-92a5uwjf	110	7	access	access	NN
cord-270337-92a5uwjf	110	8	for	for	IN
cord-270337-92a5uwjf	110	9	drug	drug	NN
cord-270337-92a5uwjf	110	10	administration	administration	NN
cord-270337-92a5uwjf	110	11	.	.	.
cord-270337-92a5uwjf	111	1	The	the	DT
cord-270337-92a5uwjf	111	2	right	right	JJ
cord-270337-92a5uwjf	111	3	common	common	JJ
cord-270337-92a5uwjf	111	4	carotid	carotid	NN
cord-270337-92a5uwjf	111	5	and	and	CC
cord-270337-92a5uwjf	111	6	a	a	DT
cord-270337-92a5uwjf	111	7	femoral	femoral	JJ
cord-270337-92a5uwjf	111	8	artery	artery	NN
cord-270337-92a5uwjf	111	9	were	be	VBD
cord-270337-92a5uwjf	111	10	accessed	access	VBN
cord-270337-92a5uwjf	111	11	for	for	IN
cord-270337-92a5uwjf	111	12	measurement	measurement	NN
cord-270337-92a5uwjf	111	13	of	of	IN
cord-270337-92a5uwjf	111	14	left	left	JJ
cord-270337-92a5uwjf	111	15	ventricular	ventricular	JJ
cord-270337-92a5uwjf	111	16	pressure	pressure	NN
cord-270337-92a5uwjf	111	17	and	and	CC
cord-270337-92a5uwjf	111	18	recording	recording	NN
cord-270337-92a5uwjf	111	19	of	of	IN
cord-270337-92a5uwjf	111	20	BP	BP	NNP
cord-270337-92a5uwjf	111	21	using	use	VBG
cord-270337-92a5uwjf	111	22	a	a	DT
cord-270337-92a5uwjf	111	23	Druck	Druck	NNP
cord-270337-92a5uwjf	111	24	PDCR	PDCR	NNP
cord-270337-92a5uwjf	111	25	75	75	CD
cord-270337-92a5uwjf	111	26	or	or	CC
cord-270337-92a5uwjf	111	27	a	a	DT
cord-270337-92a5uwjf	111	28	Bell	Bell	NNP
cord-270337-92a5uwjf	111	29	and	and	CC
cord-270337-92a5uwjf	111	30	Howell	Howell	NNP
cord-270337-92a5uwjf	111	31	type	type	NN
cord-270337-92a5uwjf	111	32	4	4	CD
cord-270337-92a5uwjf	111	33	-	-	SYM
cord-270337-92a5uwjf	111	34	422	422	CD
cord-270337-92a5uwjf	111	35	-	-	HYPH
cord-270337-92a5uwjf	111	36	0001	0001	CD
cord-270337-92a5uwjf	111	37	pressure	pressure	NN
cord-270337-92a5uwjf	111	38	transducer	transducer	NN
cord-270337-92a5uwjf	111	39	.	.	.
cord-270337-92a5uwjf	112	1	A	a	DT
cord-270337-92a5uwjf	112	2	tracheotomy	tracheotomy	NN
cord-270337-92a5uwjf	112	3	was	be	VBD
cord-270337-92a5uwjf	112	4	performed	perform	VBN
cord-270337-92a5uwjf	112	5	to	to	TO
cord-270337-92a5uwjf	112	6	facilitate	facilitate	VB
cord-270337-92a5uwjf	112	7	respiration	respiration	NN
cord-270337-92a5uwjf	112	8	,	,	,
cord-270337-92a5uwjf	112	9	and	and	CC
cord-270337-92a5uwjf	112	10	a	a	DT
cord-270337-92a5uwjf	112	11	wide	wide	JJ
cord-270337-92a5uwjf	112	12	bore	bore	NN
cord-270337-92a5uwjf	112	13	cannula	cannula	NN
cord-270337-92a5uwjf	112	14	secured	secure	VBN
cord-270337-92a5uwjf	112	15	in	in	IN
cord-270337-92a5uwjf	112	16	place	place	NN
cord-270337-92a5uwjf	112	17	.	.	.
cord-270337-92a5uwjf	113	1	Subcutaneous	subcutaneous	JJ
cord-270337-92a5uwjf	113	2	stainless	stainless	JJ
cord-270337-92a5uwjf	113	3	-	-	HYPH
cord-270337-92a5uwjf	113	4	steel	steel	NN
cord-270337-92a5uwjf	113	5	needle	needle	NN
cord-270337-92a5uwjf	113	6	electrodes	electrode	NNS
cord-270337-92a5uwjf	113	7	were	be	VBD
cord-270337-92a5uwjf	113	8	inserted	insert	VBN
cord-270337-92a5uwjf	113	9	to	to	IN
cord-270337-92a5uwjf	113	10	each	each	DT
cord-270337-92a5uwjf	113	11	limb	limb	NN
cord-270337-92a5uwjf	113	12	for	for	IN
cord-270337-92a5uwjf	113	13	the	the	DT
cord-270337-92a5uwjf	113	14	recording	recording	NN
cord-270337-92a5uwjf	113	15	of	of	IN
cord-270337-92a5uwjf	113	16	the	the	DT
cord-270337-92a5uwjf	113	17	ECG	ECG	NNP
cord-270337-92a5uwjf	113	18	.	.	.
cord-270337-92a5uwjf	114	1	All	all	DT
cord-270337-92a5uwjf	114	2	animals	animal	NNS
cord-270337-92a5uwjf	114	3	were	be	VBD
cord-270337-92a5uwjf	114	4	maintained	maintain	VBN
cord-270337-92a5uwjf	114	5	at	at	IN
cord-270337-92a5uwjf	114	6	a	a	DT
cord-270337-92a5uwjf	114	7	rectal	rectal	JJ
cord-270337-92a5uwjf	114	8	temperature	temperature	NN
cord-270337-92a5uwjf	114	9	of	of	IN
cord-270337-92a5uwjf	114	10	37	37	CD
cord-270337-92a5uwjf	114	11	C.	C.	NNP
cord-270337-92a5uwjf	114	12	Ventilation	Ventilation	NNP
cord-270337-92a5uwjf	114	13	necessitated	necessitate	VBD
cord-270337-92a5uwjf	114	14	a	a	DT
cord-270337-92a5uwjf	114	15	thoracotomy	thoracotomy	NN
cord-270337-92a5uwjf	114	16	at	at	IN
cord-270337-92a5uwjf	114	17	the	the	DT
cord-270337-92a5uwjf	114	18	fifth	fifth	JJ
cord-270337-92a5uwjf	114	19	intercostal	intercostal	JJ
cord-270337-92a5uwjf	114	20	space	space	NN
cord-270337-92a5uwjf	114	21	as	as	IN
cord-270337-92a5uwjf	114	22	,	,	,
cord-270337-92a5uwjf	114	23	in	in	IN
cord-270337-92a5uwjf	114	24	closed	close	VBN
cord-270337-92a5uwjf	114	25	-	-	HYPH
cord-270337-92a5uwjf	114	26	chest	chest	NN
cord-270337-92a5uwjf	114	27	rats	rat	NNS
cord-270337-92a5uwjf	114	28	,	,	,
cord-270337-92a5uwjf	114	29	excessive	excessive	JJ
cord-270337-92a5uwjf	114	30	contractions	contraction	NNS
cord-270337-92a5uwjf	114	31	of	of	IN
cord-270337-92a5uwjf	114	32	the	the	DT
cord-270337-92a5uwjf	114	33	diaphragm	diaphragm	NN
cord-270337-92a5uwjf	114	34	and	and	CC
cord-270337-92a5uwjf	114	35	intercostal	intercostal	JJ
cord-270337-92a5uwjf	114	36	muscles	muscle	NNS
cord-270337-92a5uwjf	114	37	were	be	VBD
cord-270337-92a5uwjf	114	38	found	find	VBN
cord-270337-92a5uwjf	114	39	to	to	TO
cord-270337-92a5uwjf	114	40	prevent	prevent	VB
cord-270337-92a5uwjf	114	41	effective	effective	JJ
cord-270337-92a5uwjf	114	42	respiration	respiration	NN
cord-270337-92a5uwjf	114	43	.	.	.
cord-270337-92a5uwjf	115	1	A	a	DT
cord-270337-92a5uwjf	115	2	positive	positive	JJ
cord-270337-92a5uwjf	115	3	end	end	NN
cord-270337-92a5uwjf	115	4	-	-	HYPH
cord-270337-92a5uwjf	115	5	expiratory	expiratory	NN
cord-270337-92a5uwjf	115	6	pressure	pressure	NN
cord-270337-92a5uwjf	115	7	was	be	VBD
cord-270337-92a5uwjf	115	8	exerted	exert	VBN
cord-270337-92a5uwjf	115	9	and	and	CC
cord-270337-92a5uwjf	115	10	air	air	NN
cord-270337-92a5uwjf	115	11	ventilation	ventilation	NN
cord-270337-92a5uwjf	115	12	provided	provide	VBN
cord-270337-92a5uwjf	115	13	at	at	IN
cord-270337-92a5uwjf	115	14	54	54	CD
cord-270337-92a5uwjf	115	15	strokesÁmin	strokesámin	JJ
cord-270337-92a5uwjf	115	16	−1	−1	NNP
cord-270337-92a5uwjf	115	17	(	(	-LRB-
cord-270337-92a5uwjf	115	18	3	3	CD
cord-270337-92a5uwjf	115	19	-	-	SYM
cord-270337-92a5uwjf	115	20	4.5	4.5	CD
cord-270337-92a5uwjf	115	21	ml	ml	NNS
cord-270337-92a5uwjf	115	22	per	per	IN
cord-270337-92a5uwjf	115	23	stroke	stroke	NN
cord-270337-92a5uwjf	115	24	)	)	-RRB-
cord-270337-92a5uwjf	115	25	using	use	VBG
cord-270337-92a5uwjf	115	26	a	a	DT
cord-270337-92a5uwjf	115	27	Harvard	Harvard	NNP
cord-270337-92a5uwjf	115	28	Bioscience	Bioscience	NNP
cord-270337-92a5uwjf	115	29	small	small	JJ
cord-270337-92a5uwjf	115	30	animal	animal	NN
cord-270337-92a5uwjf	115	31	respirator	respirator	NN
cord-270337-92a5uwjf	115	32	.	.	.
cord-270337-92a5uwjf	116	1	Rabbits	rabbit	NNS
cord-270337-92a5uwjf	116	2	were	be	VBD
cord-270337-92a5uwjf	116	3	ventilated	ventilate	VBN
cord-270337-92a5uwjf	116	4	with	with	IN
cord-270337-92a5uwjf	116	5	air	air	NN
cord-270337-92a5uwjf	116	6	at	at	IN
cord-270337-92a5uwjf	116	7	38	38	CD
cord-270337-92a5uwjf	116	8	strokesÁmin	strokesÁmin	NNP
cord-270337-92a5uwjf	116	9	−1	−1	NNP
cord-270337-92a5uwjf	116	10	(	(	-LRB-
cord-270337-92a5uwjf	116	11	13	13	CD
cord-270337-92a5uwjf	116	12	-	-	SYM
cord-270337-92a5uwjf	116	13	18	18	CD
cord-270337-92a5uwjf	116	14	ml	ml	NN
cord-270337-92a5uwjf	116	15	per	per	IN
cord-270337-92a5uwjf	116	16	stroke	stroke	NN
cord-270337-92a5uwjf	116	17	)	)	-RRB-
cord-270337-92a5uwjf	116	18	.	.	.
cord-270337-92a5uwjf	117	1	A	a	DT
cord-270337-92a5uwjf	117	2	thoracotomy	thoracotomy	NN
cord-270337-92a5uwjf	117	3	was	be	VBD
cord-270337-92a5uwjf	117	4	not	not	RB
cord-270337-92a5uwjf	117	5	necessary	necessary	JJ
cord-270337-92a5uwjf	117	6	in	in	IN
cord-270337-92a5uwjf	117	7	anaesthetised	anaesthetised	JJ
cord-270337-92a5uwjf	117	8	rabbits	rabbit	NNS
cord-270337-92a5uwjf	117	9	.	.	.
cord-270337-92a5uwjf	118	1	Blood	blood	NN
cord-270337-92a5uwjf	118	2	gases	gas	NNS
cord-270337-92a5uwjf	118	3	were	be	VBD
cord-270337-92a5uwjf	118	4	measured	measure	VBN
cord-270337-92a5uwjf	118	5	using	use	VBG
cord-270337-92a5uwjf	118	6	a	a	DT
cord-270337-92a5uwjf	118	7	Corning	Corning	NNP
cord-270337-92a5uwjf	118	8	158	158	CD
cord-270337-92a5uwjf	118	9	or	or	CC
cord-270337-92a5uwjf	118	10	850	850	CD
cord-270337-92a5uwjf	118	11	pH	ph	NN
cord-270337-92a5uwjf	118	12	/	/	SYM
cord-270337-92a5uwjf	118	13	blood	blood	NN
cord-270337-92a5uwjf	118	14	gas	gas	NN
cord-270337-92a5uwjf	118	15	analyser	analyser	NN
cord-270337-92a5uwjf	118	16	.	.	.
cord-270337-92a5uwjf	119	1	Stroke	stroke	NN
cord-270337-92a5uwjf	119	2	volumes	volume	NNS
cord-270337-92a5uwjf	119	3	were	be	VBD
cord-270337-92a5uwjf	119	4	adjusted	adjust	VBN
cord-270337-92a5uwjf	119	5	for	for	IN
cord-270337-92a5uwjf	120	1	pre	pre	JJ
cord-270337-92a5uwjf	120	2	-	-	JJ
cord-270337-92a5uwjf	120	3	drug	drug	JJ
cord-270337-92a5uwjf	120	4	PO	po	NN
cord-270337-92a5uwjf	120	5	2	2	CD
cord-270337-92a5uwjf	120	6	>	>	SYM
cord-270337-92a5uwjf	120	7	80	80	CD
cord-270337-92a5uwjf	120	8	mmHg	mmHg	NNS
cord-270337-92a5uwjf	120	9	and	and	CC
cord-270337-92a5uwjf	120	10	PCO	PCO	NNP
cord-270337-92a5uwjf	120	11	2	2	CD
cord-270337-92a5uwjf	120	12	>	>	SYM
cord-270337-92a5uwjf	120	13	30	30	CD
cord-270337-92a5uwjf	120	14	mmHg	mmHg	NNS
cord-270337-92a5uwjf	120	15	.	.	.
cord-270337-92a5uwjf	120	16	Animals	animal	NNS
cord-270337-92a5uwjf	120	17	were	be	VBD
cord-270337-92a5uwjf	120	18	excluded	exclude	VBN
cord-270337-92a5uwjf	120	19	with	with	IN
cord-270337-92a5uwjf	120	20	pre	pre	JJ
cord-270337-92a5uwjf	120	21	-	-	JJ
cord-270337-92a5uwjf	120	22	drug	drug	JJ
cord-270337-92a5uwjf	120	23	mean	mean	VB
cord-270337-92a5uwjf	120	24	arterial	arterial	JJ
cord-270337-92a5uwjf	120	25	BP	BP	NNP
cord-270337-92a5uwjf	120	26	<	<	XX
cord-270337-92a5uwjf	120	27	60	60	CD
cord-270337-92a5uwjf	120	28	mmHg	mmHg	NNS
cord-270337-92a5uwjf	120	29	(	(	-LRB-
cord-270337-92a5uwjf	120	30	in	in	IN
cord-270337-92a5uwjf	120	31	anaesthetised	anaesthetised	JJ
cord-270337-92a5uwjf	120	32	rats	rat	NNS
cord-270337-92a5uwjf	120	33	)	)	-RRB-
cord-270337-92a5uwjf	120	34	or	or	CC
cord-270337-92a5uwjf	120	35	<	<	XX
cord-270337-92a5uwjf	120	36	40	40	CD
cord-270337-92a5uwjf	120	37	mmHg	mmHg	NNS
cord-270337-92a5uwjf	120	38	(	(	-LRB-
cord-270337-92a5uwjf	120	39	in	in	IN
cord-270337-92a5uwjf	120	40	ventilated	ventilate	VBN
cord-270337-92a5uwjf	120	41	rabbits	rabbit	NNS
cord-270337-92a5uwjf	120	42	)	)	-RRB-
cord-270337-92a5uwjf	120	43	,	,	,
cord-270337-92a5uwjf	120	44	arterial	arterial	JJ
cord-270337-92a5uwjf	120	45	PO	PO	NNP
cord-270337-92a5uwjf	120	46	2	2	CD
cord-270337-92a5uwjf	120	47	of	of	IN
cord-270337-92a5uwjf	120	48	<	<	$
cord-270337-92a5uwjf	120	49	70	70	CD
cord-270337-92a5uwjf	120	50	mmHg	mmHg	NNS
cord-270337-92a5uwjf	120	51	,	,	,
cord-270337-92a5uwjf	120	52	arterial	arterial	JJ
cord-270337-92a5uwjf	120	53	PCO	PCO	NNP
cord-270337-92a5uwjf	120	54	2	2	CD
cord-270337-92a5uwjf	121	1	<	<	XX
cord-270337-92a5uwjf	121	2	25	25	CD
cord-270337-92a5uwjf	121	3	or	or	CC
cord-270337-92a5uwjf	121	4	>	>	XX
cord-270337-92a5uwjf	121	5	40	40	CD
cord-270337-92a5uwjf	121	6	mmHg	mmHg	NNS
cord-270337-92a5uwjf	121	7	or	or	CC
cord-270337-92a5uwjf	121	8	if	if	IN
cord-270337-92a5uwjf	121	9	arrhythmias	arrhythmia	NNS
cord-270337-92a5uwjf	121	10	occurred	occur	VBD
cord-270337-92a5uwjf	121	11	during	during	IN
cord-270337-92a5uwjf	121	12	the	the	DT
cord-270337-92a5uwjf	121	13	stabilisation	stabilisation	NN
cord-270337-92a5uwjf	121	14	phase	phase	NN
cord-270337-92a5uwjf	121	15	of	of	IN
cord-270337-92a5uwjf	121	16	the	the	DT
cord-270337-92a5uwjf	121	17	experiment	experiment	NN
cord-270337-92a5uwjf	121	18	.	.	.
cord-270337-92a5uwjf	122	1	In	in	IN
cord-270337-92a5uwjf	122	2	the	the	DT
cord-270337-92a5uwjf	122	3	randomised	randomised	JJ
cord-270337-92a5uwjf	122	4	trials	trial	NNS
cord-270337-92a5uwjf	122	5	,	,	,
cord-270337-92a5uwjf	122	6	rats	rat	NNS
cord-270337-92a5uwjf	122	7	were	be	VBD
cord-270337-92a5uwjf	122	8	excluded	exclude	VBN
cord-270337-92a5uwjf	122	9	if	if	IN
cord-270337-92a5uwjf	122	10	they	-PRON-	PRP
cord-270337-92a5uwjf	122	11	died	die	VBD
cord-270337-92a5uwjf	122	12	prior	prior	RB
cord-270337-92a5uwjf	122	13	to	to	IN
cord-270337-92a5uwjf	122	14	the	the	DT
cord-270337-92a5uwjf	122	15	administration	administration	NN
cord-270337-92a5uwjf	122	16	of	of	IN
cord-270337-92a5uwjf	122	17	chloroquine	chloroquine	NNP
cord-270337-92a5uwjf	122	18	in	in	IN
cord-270337-92a5uwjf	122	19	trial	trial	NN
cord-270337-92a5uwjf	122	20	(	(	-LRB-
cord-270337-92a5uwjf	122	21	i	i	NN
cord-270337-92a5uwjf	122	22	)	)	-RRB-
cord-270337-92a5uwjf	122	23	or	or	CC
cord-270337-92a5uwjf	122	24	the	the	DT
cord-270337-92a5uwjf	122	25	treament	treament	NN
cord-270337-92a5uwjf	122	26	in	in	IN
cord-270337-92a5uwjf	122	27	trials	trial	NNS
cord-270337-92a5uwjf	122	28	(	(	-LRB-
cord-270337-92a5uwjf	122	29	ii	ii	NN
cord-270337-92a5uwjf	122	30	)	)	-RRB-
cord-270337-92a5uwjf	122	31	to	to	IN
cord-270337-92a5uwjf	122	32	(	(	-LRB-
cord-270337-92a5uwjf	122	33	vi	vi	NNP
cord-270337-92a5uwjf	122	34	)	)	-RRB-
cord-270337-92a5uwjf	122	35	.	.	.
cord-270337-92a5uwjf	123	1	Arterial	arterial	JJ
cord-270337-92a5uwjf	123	2	BP	BP	NNP
cord-270337-92a5uwjf	123	3	,	,	,
cord-270337-92a5uwjf	123	4	left	leave	VBD
cord-270337-92a5uwjf	123	5	ventricular	ventricular	JJ
cord-270337-92a5uwjf	123	6	pressure	pressure	NN
cord-270337-92a5uwjf	123	7	,	,	,
cord-270337-92a5uwjf	123	8	and	and	CC
cord-270337-92a5uwjf	123	9	its	-PRON-	PRP$
cord-270337-92a5uwjf	123	10	first	first	JJ
cord-270337-92a5uwjf	123	11	derivative	derivative	NN
cord-270337-92a5uwjf	123	12	(	(	-LRB-
cord-270337-92a5uwjf	123	13	LV	LV	NNP
cord-270337-92a5uwjf	123	14	±	±	NNP
cord-270337-92a5uwjf	123	15	dP	dP	NNP
cord-270337-92a5uwjf	123	16	/	/	SYM
cord-270337-92a5uwjf	123	17	dt	dt	NNP
cord-270337-92a5uwjf	123	18	max	max	NNP
cord-270337-92a5uwjf	123	19	)	)	-RRB-
cord-270337-92a5uwjf	123	20	and	and	CC
cord-270337-92a5uwjf	123	21	contractility	contractility	NN
cord-270337-92a5uwjf	123	22	index	index	NN
cord-270337-92a5uwjf	123	23	LV	LV	NNP
cord-270337-92a5uwjf	123	24	+	+	CC
cord-270337-92a5uwjf	123	25	dP	dP	NNP
cord-270337-92a5uwjf	123	26	/	/	SYM
cord-270337-92a5uwjf	123	27	dt	dt	NNP
cord-270337-92a5uwjf	123	28	max	max	NNP
cord-270337-92a5uwjf	123	29	/P	/P	NNP
cord-270337-92a5uwjf	123	30	,	,	,
cord-270337-92a5uwjf	123	31	left	leave	VBD
cord-270337-92a5uwjf	123	32	ventricular	ventricular	JJ
cord-270337-92a5uwjf	123	33	end	end	NN
cord-270337-92a5uwjf	123	34	-	-	HYPH
cord-270337-92a5uwjf	123	35	diastolic	diastolic	JJ
cord-270337-92a5uwjf	123	36	pressure	pressure	NN
cord-270337-92a5uwjf	123	37	,	,	,
cord-270337-92a5uwjf	123	38	heart	heart	NN
cord-270337-92a5uwjf	123	39	rate	rate	NN
cord-270337-92a5uwjf	123	40	and	and	CC
cord-270337-92a5uwjf	123	41	ECG	ECG	NNP
cord-270337-92a5uwjf	123	42	(	(	-LRB-
cord-270337-92a5uwjf	123	43	lead	lead	JJ
cord-270337-92a5uwjf	123	44	II	II	NNP
cord-270337-92a5uwjf	123	45	)	)	-RRB-
cord-270337-92a5uwjf	123	46	were	be	VBD
cord-270337-92a5uwjf	123	47	measured	measure	VBN
cord-270337-92a5uwjf	123	48	and	and	CC
cord-270337-92a5uwjf	123	49	recorded	record	VBD
cord-270337-92a5uwjf	123	50	using	use	VBG
cord-270337-92a5uwjf	123	51	Lectromed	Lectromed	NNP
cord-270337-92a5uwjf	123	52	systems	system	NNS
cord-270337-92a5uwjf	123	53	(	(	-LRB-
cord-270337-92a5uwjf	123	54	Letchworth	Letchworth	NNP
cord-270337-92a5uwjf	123	55	,	,	,
cord-270337-92a5uwjf	123	56	Hertfordshire	Hertfordshire	NNP
cord-270337-92a5uwjf	123	57	)	)	-RRB-
cord-270337-92a5uwjf	123	58	or	or	CC
cord-270337-92a5uwjf	123	59	a	a	DT
cord-270337-92a5uwjf	123	60	Grass	Grass	NNP
cord-270337-92a5uwjf	123	61	79D	79d	CD
cord-270337-92a5uwjf	123	62	recorder	recorder	NN
cord-270337-92a5uwjf	123	63	(	(	-LRB-
cord-270337-92a5uwjf	123	64	Quincy	Quincy	NNP
cord-270337-92a5uwjf	123	65	,	,	,
cord-270337-92a5uwjf	123	66	Massachusetts	Massachusetts	NNP
cord-270337-92a5uwjf	123	67	)	)	-RRB-
cord-270337-92a5uwjf	123	68	connected	connect	VBD
cord-270337-92a5uwjf	123	69	to	to	IN
cord-270337-92a5uwjf	123	70	a	a	DT
cord-270337-92a5uwjf	123	71	Po	Po	NNP
cord-270337-92a5uwjf	123	72	-	-	HYPH
cord-270337-92a5uwjf	123	73	Ne	Ne	NNP
cord-270337-92a5uwjf	123	74	-	-	HYPH
cord-270337-92a5uwjf	123	75	Mah	Mah	NNP
cord-270337-92a5uwjf	123	76	digital	digital	JJ
cord-270337-92a5uwjf	123	77	data	data	NN
cord-270337-92a5uwjf	123	78	acquisition	acquisition	NN
cord-270337-92a5uwjf	123	79	system	system	NN
cord-270337-92a5uwjf	123	80	(	(	-LRB-
cord-270337-92a5uwjf	123	81	Linton	Linton	NNP
cord-270337-92a5uwjf	123	82	,	,	,
cord-270337-92a5uwjf	123	83	Diss	Diss	NNP
cord-270337-92a5uwjf	123	84	,	,	,
cord-270337-92a5uwjf	123	85	Norfolk	Norfolk	NNP
cord-270337-92a5uwjf	123	86	)	)	-RRB-
cord-270337-92a5uwjf	123	87	and	and	CC
cord-270337-92a5uwjf	123	88	recorded	record	VBD
cord-270337-92a5uwjf	123	89	at	at	IN
cord-270337-92a5uwjf	123	90	a	a	DT
cord-270337-92a5uwjf	123	91	sampling	sampling	NN
cord-270337-92a5uwjf	123	92	rate	rate	NN
cord-270337-92a5uwjf	123	93	of	of	IN
cord-270337-92a5uwjf	123	94	1,000	1,000	CD
cord-270337-92a5uwjf	123	95	Hz	Hz	NNS
cord-270337-92a5uwjf	123	96	.	.	.
cord-270337-92a5uwjf	124	1	Blood	blood	NN
cord-270337-92a5uwjf	124	2	samples	sample	NNS
cord-270337-92a5uwjf	124	3	for	for	IN
cord-270337-92a5uwjf	124	4	the	the	DT
cord-270337-92a5uwjf	124	5	determination	determination	NN
cord-270337-92a5uwjf	124	6	of	of	IN
cord-270337-92a5uwjf	124	7	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	124	8	concentration	concentration	NN
cord-270337-92a5uwjf	124	9	were	be	VBD
cord-270337-92a5uwjf	124	10	obtained	obtain	VBN
cord-270337-92a5uwjf	124	11	from	from	IN
cord-270337-92a5uwjf	124	12	trial	trial	NN
cord-270337-92a5uwjf	124	13	(	(	-LRB-
cord-270337-92a5uwjf	124	14	iv	iv	LS
cord-270337-92a5uwjf	124	15	)	)	-RRB-
cord-270337-92a5uwjf	124	16	.	.	.
cord-270337-92a5uwjf	125	1	Approximately	approximately	RB
cord-270337-92a5uwjf	125	2	250-μl	250-μl	CD
cord-270337-92a5uwjf	125	3	arterial	arterial	JJ
cord-270337-92a5uwjf	125	4	blood	blood	NN
cord-270337-92a5uwjf	125	5	samples	sample	NNS
cord-270337-92a5uwjf	125	6	were	be	VBD
cord-270337-92a5uwjf	125	7	drawn	draw	VBN
cord-270337-92a5uwjf	125	8	after	after	IN
cord-270337-92a5uwjf	125	9	25	25	CD
cord-270337-92a5uwjf	125	10	,	,	,
cord-270337-92a5uwjf	125	11	45	45	CD
cord-270337-92a5uwjf	125	12	and	and	CC
cord-270337-92a5uwjf	125	13	60	60	CD
cord-270337-92a5uwjf	125	14	min	min	NN
cord-270337-92a5uwjf	125	15	of	of	IN
cord-270337-92a5uwjf	125	16	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	125	17	infusion	infusion	NN
cord-270337-92a5uwjf	125	18	from	from	IN
cord-270337-92a5uwjf	125	19	six	six	CD
cord-270337-92a5uwjf	125	20	rats	rat	NNS
cord-270337-92a5uwjf	125	21	for	for	IN
cord-270337-92a5uwjf	125	22	the	the	DT
cord-270337-92a5uwjf	125	23	analysis	analysis	NN
cord-270337-92a5uwjf	125	24	of	of	IN
cord-270337-92a5uwjf	125	25	whole	whole	JJ
cord-270337-92a5uwjf	125	26	blood	blood	NN
cord-270337-92a5uwjf	125	27	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	125	28	concentrations	concentration	NNS
cord-270337-92a5uwjf	125	29	.	.	.
cord-270337-92a5uwjf	126	1	Four	four	CD
cord-270337-92a5uwjf	126	2	50-μl	50-μl	CD
cord-270337-92a5uwjf	126	3	aliquots	aliquot	NNS
cord-270337-92a5uwjf	126	4	were	be	VBD
cord-270337-92a5uwjf	126	5	accurately	accurately	RB
cord-270337-92a5uwjf	126	6	pipetted	pipette	VBN
cord-270337-92a5uwjf	126	7	on	on	IN
cord-270337-92a5uwjf	126	8	to	to	IN
cord-270337-92a5uwjf	126	9	a	a	DT
cord-270337-92a5uwjf	126	10	sheet	sheet	NN
cord-270337-92a5uwjf	126	11	of	of	IN
cord-270337-92a5uwjf	126	12	Whatman	Whatman	NNP
cord-270337-92a5uwjf	126	13	grade	grade	NN
cord-270337-92a5uwjf	126	14	3	3	CD
cord-270337-92a5uwjf	126	15	blotting	blotting	NN
cord-270337-92a5uwjf	126	16	paper	paper	NN
cord-270337-92a5uwjf	126	17	and	and	CC
cord-270337-92a5uwjf	126	18	protected	protect	VBN
cord-270337-92a5uwjf	126	19	from	from	IN
cord-270337-92a5uwjf	126	20	light	light	JJ
cord-270337-92a5uwjf	126	21	exposure	exposure	NN
cord-270337-92a5uwjf	126	22	.	.	.
cord-270337-92a5uwjf	127	1	Standards	standard	NNS
cord-270337-92a5uwjf	127	2	were	be	VBD
cord-270337-92a5uwjf	127	3	prepared	prepare	VBN
cord-270337-92a5uwjf	127	4	by	by	IN
cord-270337-92a5uwjf	127	5	adding	add	VBG
cord-270337-92a5uwjf	127	6	aliquots	aliquot	NNS
cord-270337-92a5uwjf	127	7	of	of	IN
cord-270337-92a5uwjf	127	8	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	127	9	,	,	,
cord-270337-92a5uwjf	127	10	giving	give	VBG
cord-270337-92a5uwjf	127	11	final	final	JJ
cord-270337-92a5uwjf	127	12	concentrations	concentration	NNS
cord-270337-92a5uwjf	127	13	ranging	range	VBG
cord-270337-92a5uwjf	127	14	from	from	IN
cord-270337-92a5uwjf	127	15	0	0	CD
cord-270337-92a5uwjf	127	16	to	to	IN
cord-270337-92a5uwjf	127	17	30	30	CD
cord-270337-92a5uwjf	127	18	μM	μm	CD
cord-270337-92a5uwjf	127	19	,	,	,
cord-270337-92a5uwjf	127	20	on	on	IN
cord-270337-92a5uwjf	127	21	to	to	IN
cord-270337-92a5uwjf	127	22	chloroquinefree	chloroquinefree	JJ
cord-270337-92a5uwjf	127	23	blood	blood	NN
cord-270337-92a5uwjf	127	24	spots	spot	NNS
cord-270337-92a5uwjf	127	25	.	.	.
cord-270337-92a5uwjf	128	1	All	all	DT
cord-270337-92a5uwjf	128	2	samples	sample	NNS
cord-270337-92a5uwjf	128	3	were	be	VBD
cord-270337-92a5uwjf	128	4	carefully	carefully	RB
cord-270337-92a5uwjf	128	5	cut	cut	VBN
cord-270337-92a5uwjf	128	6	from	from	IN
cord-270337-92a5uwjf	128	7	the	the	DT
cord-270337-92a5uwjf	128	8	surrounding	surround	VBG
cord-270337-92a5uwjf	128	9	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	128	10	was	be	VBD
cord-270337-92a5uwjf	128	11	detected	detect	VBN
cord-270337-92a5uwjf	128	12	using	use	VBG
cord-270337-92a5uwjf	128	13	an	an	DT
cord-270337-92a5uwjf	128	14	Isochrom	Isochrom	NNP
cord-270337-92a5uwjf	128	15	LC	LC	NNP
cord-270337-92a5uwjf	128	16	Spectra	Spectra	NNP
cord-270337-92a5uwjf	128	17	-	-	HYPH
cord-270337-92a5uwjf	128	18	Physics	Physics	NNP
cord-270337-92a5uwjf	128	19	pump	pump	NN
cord-270337-92a5uwjf	128	20	equipped	equip	VBN
cord-270337-92a5uwjf	128	21	with	with	IN
cord-270337-92a5uwjf	128	22	a	a	DT
cord-270337-92a5uwjf	128	23	Rheodyne	Rheodyne	NNP
cord-270337-92a5uwjf	128	24	injector	injector	NN
cord-270337-92a5uwjf	128	25	,	,	,
cord-270337-92a5uwjf	128	26	a	a	DT
cord-270337-92a5uwjf	128	27	Spectra	Spectra	NNP
cord-270337-92a5uwjf	128	28	100	100	CD
cord-270337-92a5uwjf	128	29	fluorescence	fluorescence	NN
cord-270337-92a5uwjf	128	30	detector	detector	NN
cord-270337-92a5uwjf	128	31	,	,	,
cord-270337-92a5uwjf	128	32	and	and	CC
cord-270337-92a5uwjf	128	33	a	a	DT
cord-270337-92a5uwjf	128	34	Chromjet	Chromjet	NNP
cord-270337-92a5uwjf	128	35	integrator	integrator	NN
cord-270337-92a5uwjf	128	36	.	.	.
cord-270337-92a5uwjf	129	1	The	the	DT
cord-270337-92a5uwjf	129	2	excitation	excitation	NN
cord-270337-92a5uwjf	129	3	wavelength	wavelength	NN
cord-270337-92a5uwjf	129	4	was	be	VBD
cord-270337-92a5uwjf	129	5	340	340	CD
cord-270337-92a5uwjf	129	6	nm	nm	NN
cord-270337-92a5uwjf	129	7	,	,	,
cord-270337-92a5uwjf	129	8	and	and	CC
cord-270337-92a5uwjf	129	9	a	a	DT
cord-270337-92a5uwjf	129	10	370-nm	370-nm	CD
cord-270337-92a5uwjf	129	11	emission	emission	NN
cord-270337-92a5uwjf	129	12	filter	filter	NN
cord-270337-92a5uwjf	129	13	was	be	VBD
cord-270337-92a5uwjf	129	14	used	use	VBN
cord-270337-92a5uwjf	130	1	(	(	-LRB-
cord-270337-92a5uwjf	130	2	Looareesuwan	Looareesuwan	NNP
cord-270337-92a5uwjf	130	3	et	et	FW
cord-270337-92a5uwjf	130	4	al	al	NNP
cord-270337-92a5uwjf	130	5	.	.	NNP
cord-270337-92a5uwjf	130	6	,	,	,
cord-270337-92a5uwjf	130	7	1986	1986	CD
cord-270337-92a5uwjf	130	8	)	)	-RRB-
cord-270337-92a5uwjf	130	9	.	.	.
cord-270337-92a5uwjf	131	1	The	the	DT
cord-270337-92a5uwjf	131	2	column	column	NN
cord-270337-92a5uwjf	131	3	(	(	-LRB-
cord-270337-92a5uwjf	131	4	0.25	0.25	CD
cord-270337-92a5uwjf	131	5	m	m	NN
cord-270337-92a5uwjf	131	6	×	×	NNP
cord-270337-92a5uwjf	131	7	4.6	4.6	CD
cord-270337-92a5uwjf	131	8	mm	mm	CD
cord-270337-92a5uwjf	131	9	of	of	IN
cord-270337-92a5uwjf	131	10	internal	internal	JJ
cord-270337-92a5uwjf	131	11	diameter	diameter	NN
cord-270337-92a5uwjf	131	12	)	)	-RRB-
cord-270337-92a5uwjf	131	13	was	be	VBD
cord-270337-92a5uwjf	131	14	packed	pack	VBN
cord-270337-92a5uwjf	131	15	with	with	IN
cord-270337-92a5uwjf	131	16	Spherisorb	Spherisorb	NNP
cord-270337-92a5uwjf	131	17	silica	silica	NN
cord-270337-92a5uwjf	131	18	(	(	-LRB-
cord-270337-92a5uwjf	131	19	5-μM	5-μm	CD
cord-270337-92a5uwjf	131	20	particles	particle	NNS
cord-270337-92a5uwjf	131	21	;	;	:
cord-270337-92a5uwjf	131	22	Capital	Capital	NNP
cord-270337-92a5uwjf	131	23	HPLC	HPLC	NNP
cord-270337-92a5uwjf	131	24	)	)	-RRB-
cord-270337-92a5uwjf	131	25	and	and	CC
cord-270337-92a5uwjf	131	26	eluted	elute	VBD
cord-270337-92a5uwjf	131	27	with	with	IN
cord-270337-92a5uwjf	131	28	an	an	DT
cord-270337-92a5uwjf	131	29	isocratic	isocratic	JJ
cord-270337-92a5uwjf	131	30	mobile	mobile	NN
cord-270337-92a5uwjf	131	31	phase	phase	NN
cord-270337-92a5uwjf	131	32	consisting	consist	VBG
cord-270337-92a5uwjf	131	33	of	of	IN
cord-270337-92a5uwjf	131	34	acetonitrile	acetonitrile	NN
cord-270337-92a5uwjf	131	35	:	:	:
cord-270337-92a5uwjf	131	36	methanol	methanol	NN
cord-270337-92a5uwjf	131	37	:	:	:
cord-270337-92a5uwjf	131	38	diethylamine	diethylamine	NNP
cord-270337-92a5uwjf	131	39	(	(	-LRB-
cord-270337-92a5uwjf	131	40	94:5.5:0.5	94:5.5:0.5	NFP
cord-270337-92a5uwjf	131	41	)	)	-RRB-
cord-270337-92a5uwjf	131	42	,	,	,
cord-270337-92a5uwjf	131	43	flowing	flow	VBG
cord-270337-92a5uwjf	131	44	at	at	IN
cord-270337-92a5uwjf	131	45	1.5	1.5	CD
cord-270337-92a5uwjf	131	46	mlÁmin	mlámin	CD
cord-270337-92a5uwjf	131	47	−1	−1	NNP
cord-270337-92a5uwjf	131	48	.	.	.
cord-270337-92a5uwjf	132	1	The	the	DT
cord-270337-92a5uwjf	132	2	limit	limit	NN
cord-270337-92a5uwjf	132	3	of	of	IN
cord-270337-92a5uwjf	132	4	detection	detection	NN
cord-270337-92a5uwjf	132	5	for	for	IN
cord-270337-92a5uwjf	132	6	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	132	7	was	be	VBD
cord-270337-92a5uwjf	132	8	3.1	3.1	CD
cord-270337-92a5uwjf	132	9	nM	nm	NN
cord-270337-92a5uwjf	132	10	,	,	,
cord-270337-92a5uwjf	132	11	and	and	CC
cord-270337-92a5uwjf	132	12	the	the	DT
cord-270337-92a5uwjf	132	13	precision	precision	NN
cord-270337-92a5uwjf	132	14	of	of	IN
cord-270337-92a5uwjf	132	15	the	the	DT
cord-270337-92a5uwjf	132	16	method	method	NN
cord-270337-92a5uwjf	132	17	was	be	VBD
cord-270337-92a5uwjf	132	18	3.5	3.5	CD
cord-270337-92a5uwjf	132	19	%	%	NN
cord-270337-92a5uwjf	132	20	at	at	IN
cord-270337-92a5uwjf	132	21	156	156	CD
cord-270337-92a5uwjf	132	22	nM.	nm.	NN
cord-270337-92a5uwjf	133	1	In	in	IN
cord-270337-92a5uwjf	133	2	randomised	randomised	JJ
cord-270337-92a5uwjf	133	3	trial	trial	NN
cord-270337-92a5uwjf	133	4	(	(	-LRB-
cord-270337-92a5uwjf	133	5	vi	vi	NNP
cord-270337-92a5uwjf	133	6	)	)	-RRB-
cord-270337-92a5uwjf	133	7	,	,	,
cord-270337-92a5uwjf	133	8	arterial	arterial	JJ
cord-270337-92a5uwjf	133	9	blood	blood	NN
cord-270337-92a5uwjf	133	10	samples	sample	NNS
cord-270337-92a5uwjf	133	11	were	be	VBD
cord-270337-92a5uwjf	133	12	analysed	analyse	VBN
cord-270337-92a5uwjf	133	13	for	for	IN
cord-270337-92a5uwjf	133	14	blood	blood	NN
cord-270337-92a5uwjf	133	15	gases	gas	NNS
cord-270337-92a5uwjf	133	16	,	,	,
cord-270337-92a5uwjf	133	17	pH	ph	NN
cord-270337-92a5uwjf	133	18	and	and	CC
cord-270337-92a5uwjf	133	19	electrolyte	electrolyte	NN
cord-270337-92a5uwjf	133	20	(	(	-LRB-
cord-270337-92a5uwjf	133	21	K	K	NNP
cord-270337-92a5uwjf	133	22	+	+	XX
cord-270337-92a5uwjf	133	23	,	,	,
cord-270337-92a5uwjf	133	24	Na	Na	NNP
cord-270337-92a5uwjf	133	25	+	+	CC
cord-270337-92a5uwjf	133	26	,	,	,
cord-270337-92a5uwjf	133	27	and	and	CC
cord-270337-92a5uwjf	133	28	free	free	JJ
cord-270337-92a5uwjf	134	1	Ca	ca	NN
cord-270337-92a5uwjf	134	2	2	2	CD
cord-270337-92a5uwjf	134	3	+	+	SYM
cord-270337-92a5uwjf	134	4	)	)	-RRB-
cord-270337-92a5uwjf	134	5	concentrations	concentration	NNS
cord-270337-92a5uwjf	134	6	using	use	VBG
cord-270337-92a5uwjf	134	7	Statistical	statistical	JJ
cord-270337-92a5uwjf	134	8	analyses	analysis	NNS
cord-270337-92a5uwjf	134	9	were	be	VBD
cord-270337-92a5uwjf	134	10	performed	perform	VBN
cord-270337-92a5uwjf	134	11	using	use	VBG
cord-270337-92a5uwjf	134	12	Arcus	Arcus	NNP
cord-270337-92a5uwjf	134	13	Pro	Pro	NNP
cord-270337-92a5uwjf	134	14	-	-	JJ
cord-270337-92a5uwjf	134	15	Stat	stat	JJ
cord-270337-92a5uwjf	134	16	version	version	NN
cord-270337-92a5uwjf	134	17	3.12	3.12	CD
cord-270337-92a5uwjf	134	18	.	.	.
cord-270337-92a5uwjf	135	1	The	the	DT
cord-270337-92a5uwjf	135	2	data	datum	NNS
cord-270337-92a5uwjf	135	3	and	and	CC
cord-270337-92a5uwjf	135	4	statistical	statistical	JJ
cord-270337-92a5uwjf	135	5	analysis	analysis	NN
cord-270337-92a5uwjf	135	6	comply	comply	VBP
cord-270337-92a5uwjf	135	7	with	with	IN
cord-270337-92a5uwjf	135	8	the	the	DT
cord-270337-92a5uwjf	135	9	recommendations	recommendation	NNS
cord-270337-92a5uwjf	135	10	of	of	IN
cord-270337-92a5uwjf	135	11	the	the	DT
cord-270337-92a5uwjf	135	12	British	British	NNP
cord-270337-92a5uwjf	135	13	Journal	Journal	NNP
cord-270337-92a5uwjf	135	14	of	of	IN
cord-270337-92a5uwjf	135	15	Pharmacology	Pharmacology	NNP
cord-270337-92a5uwjf	135	16	on	on	IN
cord-270337-92a5uwjf	135	17	experimental	experimental	JJ
cord-270337-92a5uwjf	135	18	design	design	NN
cord-270337-92a5uwjf	135	19	and	and	CC
cord-270337-92a5uwjf	135	20	analysis	analysis	NN
cord-270337-92a5uwjf	135	21	in	in	IN
cord-270337-92a5uwjf	135	22	pharmacology	pharmacology	NN
cord-270337-92a5uwjf	136	1	(	(	-LRB-
cord-270337-92a5uwjf	136	2	Curtis	Curtis	NNP
cord-270337-92a5uwjf	136	3	et	et	NNP
cord-270337-92a5uwjf	136	4	al	al	NNP
cord-270337-92a5uwjf	136	5	.	.	NNP
cord-270337-92a5uwjf	136	6	,	,	,
cord-270337-92a5uwjf	136	7	2018	2018	CD
cord-270337-92a5uwjf	136	8	)	)	-RRB-
cord-270337-92a5uwjf	136	9	with	with	IN
cord-270337-92a5uwjf	136	10	the	the	DT
cord-270337-92a5uwjf	136	11	exception	exception	NN
cord-270337-92a5uwjf	136	12	that	that	IN
cord-270337-92a5uwjf	136	13	the	the	DT
cord-270337-92a5uwjf	136	14	analysis	analysis	NN
cord-270337-92a5uwjf	136	15	was	be	VBD
cord-270337-92a5uwjf	136	16	not	not	RB
cord-270337-92a5uwjf	136	17	blinded	blind	VBN
cord-270337-92a5uwjf	136	18	.	.	.
cord-270337-92a5uwjf	136	19	 	 	_SP
cord-270337-92a5uwjf	137	1	Tissues	tissue	NNS
cord-270337-92a5uwjf	137	2	from	from	IN
cord-270337-92a5uwjf	137	3	57	57	CD
cord-270337-92a5uwjf	137	4	rats	rat	NNS
cord-270337-92a5uwjf	137	5	(	(	-LRB-
cord-270337-92a5uwjf	137	6	272	272	CD
cord-270337-92a5uwjf	137	7	±	±	CD
cord-270337-92a5uwjf	137	8	4	4	CD
cord-270337-92a5uwjf	137	9	g	g	NNP
cord-270337-92a5uwjf	137	10	)	)	-RRB-
cord-270337-92a5uwjf	137	11	were	be	VBD
cord-270337-92a5uwjf	137	12	used	use	VBN
cord-270337-92a5uwjf	137	13	.	.	.
cord-270337-92a5uwjf	138	1	Decreases	decrease	NNS
cord-270337-92a5uwjf	138	2	in	in	IN
cord-270337-92a5uwjf	138	3	the	the	DT
cord-270337-92a5uwjf	138	4	developed	develop	VBN
cord-270337-92a5uwjf	138	5	tension	tension	NN
cord-270337-92a5uwjf	138	6	of	of	IN
cord-270337-92a5uwjf	138	7	left	left	JJ
cord-270337-92a5uwjf	138	8	atria	atria	NN
cord-270337-92a5uwjf	138	9	were	be	VBD
cord-270337-92a5uwjf	138	10	observed	observe	VBN
cord-270337-92a5uwjf	138	11	with	with	IN
cord-270337-92a5uwjf	138	12	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	138	13	at	at	IN
cord-270337-92a5uwjf	138	14	the	the	DT
cord-270337-92a5uwjf	138	15	highest	high	JJS
cord-270337-92a5uwjf	138	16	concentration	concentration	NN
cord-270337-92a5uwjf	138	17	of	of	IN
cord-270337-92a5uwjf	138	18	100	100	CD
cord-270337-92a5uwjf	138	19	μM.	μm.	NN
cord-270337-92a5uwjf	138	20	The	the	DT
cord-270337-92a5uwjf	138	21	negative	negative	JJ
cord-270337-92a5uwjf	138	22	inotropic	inotropic	JJ
cord-270337-92a5uwjf	138	23	effect	effect	NN
cord-270337-92a5uwjf	138	24	was	be	VBD
cord-270337-92a5uwjf	138	25	time	time	NN
cord-270337-92a5uwjf	138	26	dependent	dependent	JJ
cord-270337-92a5uwjf	138	27	,	,	,
cord-270337-92a5uwjf	138	28	with	with	IN
cord-270337-92a5uwjf	138	29	maximal	maximal	JJ
cord-270337-92a5uwjf	138	30	changes	change	NNS
cord-270337-92a5uwjf	138	31	observed	observe	VBN
cord-270337-92a5uwjf	138	32	by	by	IN
cord-270337-92a5uwjf	138	33	30	30	CD
cord-270337-92a5uwjf	138	34	min	min	NN
cord-270337-92a5uwjf	138	35	.	.	.
cord-270337-92a5uwjf	139	1	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	139	2	did	do	VBD
cord-270337-92a5uwjf	139	3	not	not	RB
cord-270337-92a5uwjf	139	4	significantly	significantly	RB
cord-270337-92a5uwjf	139	5	alter	alter	VB
cord-270337-92a5uwjf	139	6	the	the	DT
cord-270337-92a5uwjf	139	7	developed	develop	VBN
cord-270337-92a5uwjf	139	8	tension	tension	NN
cord-270337-92a5uwjf	139	9	or	or	CC
cord-270337-92a5uwjf	139	10	time	time	NN
cord-270337-92a5uwjf	139	11	to	to	TO
cord-270337-92a5uwjf	139	12	peak	peak	VB
cord-270337-92a5uwjf	139	13	tension	tension	NN
cord-270337-92a5uwjf	139	14	of	of	IN
cord-270337-92a5uwjf	139	15	right	right	JJ
cord-270337-92a5uwjf	139	16	ventricular	ventricular	JJ
cord-270337-92a5uwjf	139	17	strips	strip	NNS
cord-270337-92a5uwjf	139	18	or	or	CC
cord-270337-92a5uwjf	139	19	papillary	papillary	JJ
cord-270337-92a5uwjf	139	20	muscles	muscle	NNS
cord-270337-92a5uwjf	139	21	but	but	CC
cord-270337-92a5uwjf	139	22	significantly	significantly	RB
cord-270337-92a5uwjf	139	23	increased	increase	VBD
cord-270337-92a5uwjf	139	24	the	the	DT
cord-270337-92a5uwjf	139	25	time	time	NN
cord-270337-92a5uwjf	139	26	to	to	TO
cord-270337-92a5uwjf	139	27	peak	peak	VB
cord-270337-92a5uwjf	139	28	tension	tension	NN
cord-270337-92a5uwjf	139	29	in	in	IN
cord-270337-92a5uwjf	139	30	atria	atria	NN
cord-270337-92a5uwjf	139	31	(	(	-LRB-
cord-270337-92a5uwjf	139	32	70	70	CD
cord-270337-92a5uwjf	139	33	±	±	NNP
cord-270337-92a5uwjf	139	34	4	4	CD
cord-270337-92a5uwjf	139	35	ms	ms	NNP
cord-270337-92a5uwjf	139	36	with	with	IN
cord-270337-92a5uwjf	139	37	chloroquine	chloroquine	NNP
cord-270337-92a5uwjf	139	38	[	[	-LRB-
cord-270337-92a5uwjf	139	39	100	100	CD
cord-270337-92a5uwjf	139	40	μM	μm	NN
cord-270337-92a5uwjf	139	41	]	]	-RRB-
cord-270337-92a5uwjf	139	42	compared	compare	VBN
cord-270337-92a5uwjf	139	43	to	to	IN
cord-270337-92a5uwjf	139	44	54	54	CD
cord-270337-92a5uwjf	139	45	±	±	CD
cord-270337-92a5uwjf	139	46	2	2	CD
cord-270337-92a5uwjf	139	47	ms	ms	NNP
cord-270337-92a5uwjf	139	48	in	in	IN
cord-270337-92a5uwjf	139	49	the	the	DT
cord-270337-92a5uwjf	139	50	control	control	NN
cord-270337-92a5uwjf	139	51	group	group	NN
cord-270337-92a5uwjf	139	52	)	)	-RRB-
cord-270337-92a5uwjf	139	53	.	.	.
cord-270337-92a5uwjf	140	1	Chloroquine	chloroquine	NN
cord-270337-92a5uwjf	140	2	prolonged	prolong	VBD
cord-270337-92a5uwjf	140	3	the	the	DT
cord-270337-92a5uwjf	140	4	ERP	ERP	NNP
cord-270337-92a5uwjf	140	5	of	of	IN
cord-270337-92a5uwjf	140	6	all	all	DT
cord-270337-92a5uwjf	140	7	tissues	tissue	NNS
cord-270337-92a5uwjf	140	8	.	.	.
cord-270337-92a5uwjf	141	1	In	in	IN
cord-270337-92a5uwjf	141	2	left	left	JJ
cord-270337-92a5uwjf	141	3	atria	atria	NN
cord-270337-92a5uwjf	141	4	,	,	,
cord-270337-92a5uwjf	141	5	for	for	IN
cord-270337-92a5uwjf	141	6	instance	instance	NN
cord-270337-92a5uwjf	141	7	,	,	,
cord-270337-92a5uwjf	141	8	the	the	DT
cord-270337-92a5uwjf	141	9	prechloroquine	prechloroquine	NNP
cord-270337-92a5uwjf	141	10	ERP	ERP	NNP
cord-270337-92a5uwjf	141	11	was	be	VBD
cord-270337-92a5uwjf	141	12	41	41	CD
cord-270337-92a5uwjf	142	1	±	±	NNP
cord-270337-92a5uwjf	142	2	2	2	CD
cord-270337-92a5uwjf	142	3	ms	ms	NNP
cord-270337-92a5uwjf	142	4	(	(	-LRB-
cord-270337-92a5uwjf	142	5	in	in	IN
cord-270337-92a5uwjf	142	6	the	the	DT
cord-270337-92a5uwjf	142	7	30	30	CD
cord-270337-92a5uwjf	142	8	μM	μm	CD
cord-270337-92a5uwjf	142	9	group	group	NN
cord-270337-92a5uwjf	142	10	)	)	-RRB-
cord-270337-92a5uwjf	142	11	,	,	,
cord-270337-92a5uwjf	142	12	which	which	WDT
cord-270337-92a5uwjf	142	13	significantly	significantly	RB
cord-270337-92a5uwjf	142	14	increased	increase	VBD
cord-270337-92a5uwjf	142	15	to	to	IN
cord-270337-92a5uwjf	142	16	72	72	CD
cord-270337-92a5uwjf	142	17	±	±	NN
cord-270337-92a5uwjf	143	1	9	9	CD
cord-270337-92a5uwjf	143	2	ms	m	NNS
cord-270337-92a5uwjf	143	3	after	after	IN
cord-270337-92a5uwjf	143	4	30-min	30-min	CD
cord-270337-92a5uwjf	143	5	exposure	exposure	NN
cord-270337-92a5uwjf	143	6	to	to	IN
cord-270337-92a5uwjf	143	7	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	143	8	.	.	.
cord-270337-92a5uwjf	144	1	Diazepam	diazepam	NN
cord-270337-92a5uwjf	144	2	alone	alone	RB
cord-270337-92a5uwjf	144	3	was	be	VBD
cord-270337-92a5uwjf	144	4	without	without	IN
cord-270337-92a5uwjf	144	5	effect	effect	NN
cord-270337-92a5uwjf	144	6	on	on	IN
cord-270337-92a5uwjf	144	7	papillary	papillary	JJ
cord-270337-92a5uwjf	144	8	muscles	muscle	NNS
cord-270337-92a5uwjf	144	9	or	or	CC
cord-270337-92a5uwjf	144	10	ventricular	ventricular	JJ
cord-270337-92a5uwjf	144	11	tissue	tissue	NN
cord-270337-92a5uwjf	144	12	other	other	JJ
cord-270337-92a5uwjf	144	13	than	than	IN
cord-270337-92a5uwjf	144	14	a	a	DT
cord-270337-92a5uwjf	144	15	small	small	JJ
cord-270337-92a5uwjf	144	16	but	but	CC
cord-270337-92a5uwjf	144	17	significant	significant	JJ
cord-270337-92a5uwjf	144	18	increase	increase	NN
cord-270337-92a5uwjf	144	19	from	from	IN
cord-270337-92a5uwjf	144	20	65	65	CD
cord-270337-92a5uwjf	144	21	±	±	CD
cord-270337-92a5uwjf	144	22	2	2	CD
cord-270337-92a5uwjf	144	23	to	to	IN
cord-270337-92a5uwjf	144	24	74	74	CD
cord-270337-92a5uwjf	144	25	±	±	CD
cord-270337-92a5uwjf	144	26	2	2	CD
cord-270337-92a5uwjf	145	1	ms	ms	NNP
cord-270337-92a5uwjf	145	2	in	in	IN
cord-270337-92a5uwjf	145	3	the	the	DT
cord-270337-92a5uwjf	145	4	time	time	NN
cord-270337-92a5uwjf	145	5	to	to	TO
cord-270337-92a5uwjf	145	6	peak	peak	VB
cord-270337-92a5uwjf	145	7	tension	tension	NN
cord-270337-92a5uwjf	145	8	of	of	IN
cord-270337-92a5uwjf	145	9	contracting	contract	VBG
cord-270337-92a5uwjf	145	10	right	right	JJ
cord-270337-92a5uwjf	145	11	ventricular	ventricular	JJ
cord-270337-92a5uwjf	145	12	strips	strip	NNS
cord-270337-92a5uwjf	145	13	at	at	IN
cord-270337-92a5uwjf	145	14	100	100	CD
cord-270337-92a5uwjf	146	1	μM.	μM.	NNP
cord-270337-92a5uwjf	147	1	However	however	RB
cord-270337-92a5uwjf	147	2	,	,	,
cord-270337-92a5uwjf	147	3	diazepam	diazepam	NN
cord-270337-92a5uwjf	147	4	of	of	IN
cord-270337-92a5uwjf	147	5	100	100	CD
cord-270337-92a5uwjf	147	6	μM	μm	CD
cord-270337-92a5uwjf	147	7	evoked	evoke	VBD
cord-270337-92a5uwjf	147	8	a	a	DT
cord-270337-92a5uwjf	147	9	positive	positive	JJ
cord-270337-92a5uwjf	147	10	inotropic	inotropic	NNP
cord-270337-92a5uwjf	147	11	response	response	NN
cord-270337-92a5uwjf	147	12	and	and	CC
cord-270337-92a5uwjf	147	13	prolonged	prolong	VBD
cord-270337-92a5uwjf	147	14	the	the	DT
cord-270337-92a5uwjf	147	15	ERP	ERP	NNP
cord-270337-92a5uwjf	147	16	of	of	IN
cord-270337-92a5uwjf	147	17	left	left	JJ
cord-270337-92a5uwjf	147	18	atria	atria	NN
cord-270337-92a5uwjf	147	19	and	and	CC
cord-270337-92a5uwjf	147	20	had	have	VBD
cord-270337-92a5uwjf	147	21	a	a	DT
cord-270337-92a5uwjf	147	22	significant	significant	JJ
cord-270337-92a5uwjf	147	23	negative	negative	JJ
cord-270337-92a5uwjf	147	24	chronotropic	chronotropic	JJ
cord-270337-92a5uwjf	147	25	effect	effect	NN
cord-270337-92a5uwjf	147	26	on	on	IN
cord-270337-92a5uwjf	147	27	right	right	JJ
cord-270337-92a5uwjf	147	28	atria	atria	NN
cord-270337-92a5uwjf	147	29	(	(	-LRB-
cord-270337-92a5uwjf	147	30	213	213	CD
cord-270337-92a5uwjf	147	31	±	±	CD
cord-270337-92a5uwjf	147	32	11	11	CD
cord-270337-92a5uwjf	147	33	vs.	vs.	NN
cord-270337-92a5uwjf	147	34	290	290	CD
cord-270337-92a5uwjf	147	35	±	±	CD
cord-270337-92a5uwjf	147	36	14	14	CD
cord-270337-92a5uwjf	147	37	beatsÁmin	beatsÁmin	NNP
cord-270337-92a5uwjf	147	38	−1	−1	NNP
cord-270337-92a5uwjf	147	39	)	)	-RRB-
cord-270337-92a5uwjf	147	40	.	.	.
cord-270337-92a5uwjf	148	1	Diazepam	diazepam	NN
cord-270337-92a5uwjf	148	2	in	in	IN
cord-270337-92a5uwjf	148	3	the	the	DT
cord-270337-92a5uwjf	148	4	concentration	concentration	NN
cord-270337-92a5uwjf	148	5	range	range	NN
cord-270337-92a5uwjf	148	6	of	of	IN
cord-270337-92a5uwjf	148	7	1	1	CD
cord-270337-92a5uwjf	148	8	to	to	IN
cord-270337-92a5uwjf	148	9	100	100	CD
cord-270337-92a5uwjf	149	1	μM	μM	NNP
cord-270337-92a5uwjf	149	2	did	do	VBD
cord-270337-92a5uwjf	149	3	not	not	RB
cord-270337-92a5uwjf	149	4	appear	appear	VB
cord-270337-92a5uwjf	149	5	to	to	TO
cord-270337-92a5uwjf	149	6	protect	protect	VB
cord-270337-92a5uwjf	149	7	against	against	IN
cord-270337-92a5uwjf	149	8	the	the	DT
cord-270337-92a5uwjf	149	9	effects	effect	NNS
cord-270337-92a5uwjf	149	10	of	of	IN
cord-270337-92a5uwjf	149	11	30-μM	30-μm	CD
cord-270337-92a5uwjf	149	12	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	149	13	(	(	-LRB-
cord-270337-92a5uwjf	149	14	Table	Table	NNP
cord-270337-92a5uwjf	149	15	2	2	CD
cord-270337-92a5uwjf	149	16	)	)	-RRB-
cord-270337-92a5uwjf	149	17	.	.	.
cord-270337-92a5uwjf	150	1	At	at	IN
cord-270337-92a5uwjf	150	2	the	the	DT
cord-270337-92a5uwjf	150	3	highest	high	JJS
cord-270337-92a5uwjf	150	4	concentration	concentration	NN
cord-270337-92a5uwjf	150	5	,	,	,
cord-270337-92a5uwjf	150	6	diazepam	diazepam	NNP
cord-270337-92a5uwjf	150	7	lengthened	lengthen	VBD
cord-270337-92a5uwjf	150	8	the	the	DT
cord-270337-92a5uwjf	150	9	ERP	ERP	NNP
cord-270337-92a5uwjf	150	10	and	and	CC
cord-270337-92a5uwjf	150	11	extended	extend	VBD
cord-270337-92a5uwjf	150	12	the	the	DT
cord-270337-92a5uwjf	150	13	time	time	NN
cord-270337-92a5uwjf	150	14	to	to	TO
cord-270337-92a5uwjf	150	15	peak	peak	VB
cord-270337-92a5uwjf	150	16	tension	tension	NN
cord-270337-92a5uwjf	150	17	in	in	IN
cord-270337-92a5uwjf	150	18	left	left	JJ
cord-270337-92a5uwjf	150	19	atria	atria	NN
cord-270337-92a5uwjf	150	20	and	and	CC
cord-270337-92a5uwjf	150	21	reduced	reduced	JJ
cord-270337-92a5uwjf	150	22	rate	rate	NN
cord-270337-92a5uwjf	150	23	of	of	IN
cord-270337-92a5uwjf	150	24	beating	beat	VBG
cord-270337-92a5uwjf	150	25	right	right	JJ
cord-270337-92a5uwjf	150	26	atria	atria	NN
cord-270337-92a5uwjf	150	27	.	.	.
cord-270337-92a5uwjf	151	1	Chloroquine	chloroquine	NN
cord-270337-92a5uwjf	151	2	caused	cause	VBD
cord-270337-92a5uwjf	151	3	dose	dose	NN
cord-270337-92a5uwjf	151	4	-	-	HYPH
cord-270337-92a5uwjf	151	5	dependent	dependent	JJ
cord-270337-92a5uwjf	151	6	negative	negative	JJ
cord-270337-92a5uwjf	151	7	inotropy	inotropy	NN
cord-270337-92a5uwjf	151	8	in	in	IN
cord-270337-92a5uwjf	151	9	both	both	DT
cord-270337-92a5uwjf	151	10	species	specie	NNS
cord-270337-92a5uwjf	151	11	.	.	.
cord-270337-92a5uwjf	152	1	Reductions	reduction	NNS
cord-270337-92a5uwjf	152	2	in	in	IN
cord-270337-92a5uwjf	152	3	LV	LV	NNP
cord-270337-92a5uwjf	153	1	+	+	CC
cord-270337-92a5uwjf	154	1	dP	dP	NNP
cord-270337-92a5uwjf	154	2	/	/	SYM
cord-270337-92a5uwjf	154	3	dt	dt	NNP
cord-270337-92a5uwjf	154	4	max	max	NNP
cord-270337-92a5uwjf	154	5	during	during	IN
cord-270337-92a5uwjf	154	6	the	the	DT
cord-270337-92a5uwjf	154	7	first	first	JJ
cord-270337-92a5uwjf	154	8	2	2	CD
cord-270337-92a5uwjf	154	9	to	to	IN
cord-270337-92a5uwjf	154	10	4	4	CD
cord-270337-92a5uwjf	154	11	min	min	NN
cord-270337-92a5uwjf	154	12	of	of	IN
cord-270337-92a5uwjf	154	13	infusion	infusion	NN
cord-270337-92a5uwjf	154	14	seemed	seem	VBD
cord-270337-92a5uwjf	154	15	more	more	RBR
cord-270337-92a5uwjf	154	16	pronounced	pronounced	JJ
cord-270337-92a5uwjf	154	17	than	than	IN
cord-270337-92a5uwjf	154	18	reductions	reduction	NNS
cord-270337-92a5uwjf	154	19	in	in	IN
cord-270337-92a5uwjf	154	20	BP	BP	NNP
cord-270337-92a5uwjf	154	21	.	.	.
cord-270337-92a5uwjf	155	1	For	for	IN
cord-270337-92a5uwjf	155	2	example	example	NN
cord-270337-92a5uwjf	155	3	,	,	,
cord-270337-92a5uwjf	155	4	a	a	DT
cord-270337-92a5uwjf	155	5	47	47	CD
cord-270337-92a5uwjf	155	6	%	%	NN
cord-270337-92a5uwjf	155	7	reduction	reduction	NN
cord-270337-92a5uwjf	155	8	in	in	IN
cord-270337-92a5uwjf	155	9	LV	LV	NNP
cord-270337-92a5uwjf	156	1	+	+	CC
cord-270337-92a5uwjf	157	1	dP	dP	NNP
cord-270337-92a5uwjf	157	2	/	/	SYM
cord-270337-92a5uwjf	157	3	dt	dt	NNP
cord-270337-92a5uwjf	157	4	max	max	NNP
cord-270337-92a5uwjf	157	5	occurred	occur	VBD
cord-270337-92a5uwjf	157	6	during	during	IN
cord-270337-92a5uwjf	157	7	the	the	DT
cord-270337-92a5uwjf	157	8	first	first	JJ
cord-270337-92a5uwjf	157	9	2	2	CD
cord-270337-92a5uwjf	157	10	min	min	NN
cord-270337-92a5uwjf	157	11	of	of	IN
cord-270337-92a5uwjf	157	12	infusion	infusion	NN
cord-270337-92a5uwjf	157	13	at	at	IN
cord-270337-92a5uwjf	157	14	2	2	CD
cord-270337-92a5uwjf	157	15	mgÁkg	mgákg	NN
cord-270337-92a5uwjf	158	1	−1	−1	NNP
cord-270337-92a5uwjf	158	2	Ámin	Ámin	NNP
cord-270337-92a5uwjf	158	3	−1	−1	NNP
cord-270337-92a5uwjf	159	1	compared	compare	VBN
cord-270337-92a5uwjf	159	2	with	with	IN
cord-270337-92a5uwjf	159	3	a	a	DT
cord-270337-92a5uwjf	159	4	15	15	CD
cord-270337-92a5uwjf	159	5	%	%	NN
cord-270337-92a5uwjf	159	6	reduction	reduction	NN
cord-270337-92a5uwjf	159	7	in	in	IN
cord-270337-92a5uwjf	159	8	diastolic	diastolic	JJ
cord-270337-92a5uwjf	159	9	pressure	pressure	NN
cord-270337-92a5uwjf	159	10	for	for	IN
cord-270337-92a5uwjf	159	11	the	the	DT
cord-270337-92a5uwjf	159	12	same	same	JJ
cord-270337-92a5uwjf	159	13	period	period	NN
cord-270337-92a5uwjf	159	14	in	in	IN
cord-270337-92a5uwjf	159	15	non	non	JJ
cord-270337-92a5uwjf	159	16	-	-	JJ
cord-270337-92a5uwjf	159	17	ventilated	ventilated	JJ
cord-270337-92a5uwjf	159	18	rats	rat	NNS
cord-270337-92a5uwjf	159	19	.	.	.
cord-270337-92a5uwjf	160	1	Cardiac	cardiac	JJ
cord-270337-92a5uwjf	160	2	lusitropy	lusitropy	NN
cord-270337-92a5uwjf	160	3	(	(	-LRB-
cord-270337-92a5uwjf	160	4	LV	LV	NNP
cord-270337-92a5uwjf	160	5	−	−	NNP
cord-270337-92a5uwjf	160	6	dP	dP	NNP
cord-270337-92a5uwjf	160	7	/	/	SYM
cord-270337-92a5uwjf	160	8	dt	dt	NNP
cord-270337-92a5uwjf	160	9	max	max	NNP
cord-270337-92a5uwjf	160	10	)	)	-RRB-
cord-270337-92a5uwjf	160	11	declined	decline	VBD
cord-270337-92a5uwjf	160	12	in	in	IN
cord-270337-92a5uwjf	160	13	a	a	DT
cord-270337-92a5uwjf	160	14	parallel	parallel	JJ
cord-270337-92a5uwjf	160	15	manner	manner	NN
cord-270337-92a5uwjf	160	16	to	to	IN
cord-270337-92a5uwjf	160	17	the	the	DT
cord-270337-92a5uwjf	160	18	negative	negative	JJ
cord-270337-92a5uwjf	160	19	inotropic	inotropic	NNP
cord-270337-92a5uwjf	160	20	response	response	NN
cord-270337-92a5uwjf	160	21	.	.	.
cord-270337-92a5uwjf	161	1	Increases	increase	NNS
cord-270337-92a5uwjf	161	2	in	in	IN
cord-270337-92a5uwjf	161	3	left	left	JJ
cord-270337-92a5uwjf	161	4	ventricular	ventricular	JJ
cord-270337-92a5uwjf	161	5	end	end	NN
cord-270337-92a5uwjf	161	6	-	-	HYPH
cord-270337-92a5uwjf	161	7	diastolic	diastolic	JJ
cord-270337-92a5uwjf	161	8	pressure	pressure	NN
cord-270337-92a5uwjf	161	9	were	be	VBD
cord-270337-92a5uwjf	161	10	observed	observe	VBN
cord-270337-92a5uwjf	161	11	with	with	IN
cord-270337-92a5uwjf	161	12	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	161	13	in	in	IN
cord-270337-92a5uwjf	161	14	non	non	JJ
cord-270337-92a5uwjf	161	15	-	-	JJ
cord-270337-92a5uwjf	161	16	ventilated	ventilated	JJ
cord-270337-92a5uwjf	161	17	rats	rat	NNS
cord-270337-92a5uwjf	161	18	and	and	CC
cord-270337-92a5uwjf	161	19	ventilated	ventilate	VBN
cord-270337-92a5uwjf	161	20	rabbits	rabbit	NNS
cord-270337-92a5uwjf	161	21	.	.	.
cord-270337-92a5uwjf	162	1	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	162	2	caused	cause	VBD
cord-270337-92a5uwjf	162	3	a	a	DT
cord-270337-92a5uwjf	162	4	similar	similar	JJ
cord-270337-92a5uwjf	162	5	dose	dose	NN
cord-270337-92a5uwjf	162	6	-	-	HYPH
cord-270337-92a5uwjf	162	7	dependent	dependent	JJ
cord-270337-92a5uwjf	162	8	bradycardia	bradycardia	NN
cord-270337-92a5uwjf	162	9	over	over	IN
cord-270337-92a5uwjf	162	10	the	the	DT
cord-270337-92a5uwjf	162	11	time	time	NN
cord-270337-92a5uwjf	162	12	course	course	NN
cord-270337-92a5uwjf	162	13	of	of	IN
cord-270337-92a5uwjf	162	14	the	the	DT
cord-270337-92a5uwjf	162	15	experiment	experiment	NN
cord-270337-92a5uwjf	162	16	in	in	IN
cord-270337-92a5uwjf	162	17	both	both	CC
cord-270337-92a5uwjf	162	18	ventilated	ventilate	VBN
cord-270337-92a5uwjf	162	19	and	and	CC
cord-270337-92a5uwjf	162	20	nonventilated	nonventilated	JJ
cord-270337-92a5uwjf	162	21	rats	rat	NNS
cord-270337-92a5uwjf	162	22	for	for	IN
cord-270337-92a5uwjf	162	23	the	the	DT
cord-270337-92a5uwjf	162	24	corresponding	correspond	VBG
cord-270337-92a5uwjf	162	25	doses	dose	NNS
cord-270337-92a5uwjf	162	26	.	.	.
cord-270337-92a5uwjf	163	1	In	in	IN
cord-270337-92a5uwjf	163	2	rabbits	rabbit	NNS
cord-270337-92a5uwjf	163	3	,	,	,
cord-270337-92a5uwjf	163	4	however	however	RB
cord-270337-92a5uwjf	163	5	,	,	,
cord-270337-92a5uwjf	163	6	heart	heart	NN
cord-270337-92a5uwjf	163	7	rate	rate	NN
cord-270337-92a5uwjf	163	8	declined	decline	VBD
cord-270337-92a5uwjf	163	9	abruptly	abruptly	RB
cord-270337-92a5uwjf	163	10	by	by	IN
cord-270337-92a5uwjf	163	11	approximately	approximately	RB
cord-270337-92a5uwjf	163	12	half	half	NN
cord-270337-92a5uwjf	163	13	at	at	IN
cord-270337-92a5uwjf	163	14	time	time	NN
cord-270337-92a5uwjf	163	15	points	point	NNS
cord-270337-92a5uwjf	163	16	corresponding	correspond	VBG
cord-270337-92a5uwjf	163	17	to	to	IN
cord-270337-92a5uwjf	163	18	the	the	DT
cord-270337-92a5uwjf	163	19	onset	onset	NN
cord-270337-92a5uwjf	163	20	of	of	IN
cord-270337-92a5uwjf	163	21	arrhythmias	arrhythmia	NNS
cord-270337-92a5uwjf	163	22	.	.	.
cord-270337-92a5uwjf	164	1	In	in	IN
cord-270337-92a5uwjf	164	2	rats	rat	NNS
cord-270337-92a5uwjf	164	3	,	,	,
cord-270337-92a5uwjf	164	4	increases	increase	NNS
cord-270337-92a5uwjf	164	5	in	in	IN
cord-270337-92a5uwjf	164	6	the	the	DT
cord-270337-92a5uwjf	164	7	PR	PR	NNP
cord-270337-92a5uwjf	164	8	intervals	interval	NNS
cord-270337-92a5uwjf	164	9	occurred	occur	VBD
cord-270337-92a5uwjf	164	10	with	with	IN
cord-270337-92a5uwjf	164	11	all	all	DT
cord-270337-92a5uwjf	164	12	doses	dose	NNS
cord-270337-92a5uwjf	164	13	of	of	IN
cord-270337-92a5uwjf	164	14	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	164	15	and	and	CC
cord-270337-92a5uwjf	164	16	in	in	IN
cord-270337-92a5uwjf	164	17	proportion	proportion	NN
cord-270337-92a5uwjf	164	18	to	to	IN
cord-270337-92a5uwjf	164	19	the	the	DT
cord-270337-92a5uwjf	164	20	cumulative	cumulative	JJ
cord-270337-92a5uwjf	164	21	dose	dose	NN
cord-270337-92a5uwjf	164	22	received	receive	VBN
cord-270337-92a5uwjf	164	23	.	.	.
cord-270337-92a5uwjf	165	1	For	for	IN
cord-270337-92a5uwjf	165	2	example	example	NN
cord-270337-92a5uwjf	165	3	,	,	,
cord-270337-92a5uwjf	165	4	the	the	DT
cord-270337-92a5uwjf	165	5	PR	PR	NNP
cord-270337-92a5uwjf	165	6	interval	interval	NN
cord-270337-92a5uwjf	165	7	increased	increase	VBD
cord-270337-92a5uwjf	165	8	from	from	IN
cord-270337-92a5uwjf	165	9	52	52	CD
cord-270337-92a5uwjf	165	10	±	±	CD
cord-270337-92a5uwjf	165	11	3	3	CD
cord-270337-92a5uwjf	165	12	to	to	IN
cord-270337-92a5uwjf	165	13	68	68	CD
cord-270337-92a5uwjf	165	14	±	±	CD
cord-270337-92a5uwjf	165	15	4	4	CD
cord-270337-92a5uwjf	166	1	ms	ms	NNP
cord-270337-92a5uwjf	166	2	during	during	IN
cord-270337-92a5uwjf	166	3	the	the	DT
cord-270337-92a5uwjf	166	4	first	first	JJ
cord-270337-92a5uwjf	166	5	12	12	CD
cord-270337-92a5uwjf	166	6	min	min	NN
cord-270337-92a5uwjf	166	7	in	in	IN
cord-270337-92a5uwjf	166	8	ventilated	ventilate	VBN
cord-270337-92a5uwjf	166	9	rats	rat	NNS
cord-270337-92a5uwjf	166	10	receiving	receive	VBG
cord-270337-92a5uwjf	166	11	1	1	CD
cord-270337-92a5uwjf	166	12	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	166	13	−1	−1	NNP
cord-270337-92a5uwjf	166	14	Ámin	Ámin	NNP
cord-270337-92a5uwjf	166	15	−1	−1	NNP
cord-270337-92a5uwjf	166	16	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	166	17	,	,	,
cord-270337-92a5uwjf	166	18	and	and	CC
cord-270337-92a5uwjf	166	19	from	from	IN
cord-270337-92a5uwjf	166	20	50	50	CD
cord-270337-92a5uwjf	166	21	±	±	CD
cord-270337-92a5uwjf	166	22	2	2	CD
cord-270337-92a5uwjf	166	23	to	to	IN
cord-270337-92a5uwjf	166	24	68	68	CD
cord-270337-92a5uwjf	166	25	±	±	NNP
cord-270337-92a5uwjf	166	26	4	4	CD
cord-270337-92a5uwjf	166	27	ms	m	NNS
cord-270337-92a5uwjf	166	28	during	during	IN
cord-270337-92a5uwjf	166	29	the	the	DT
cord-270337-92a5uwjf	166	30	first	first	JJ
cord-270337-92a5uwjf	166	31	6	6	CD
cord-270337-92a5uwjf	166	32	min	min	NN
cord-270337-92a5uwjf	166	33	at	at	IN
cord-270337-92a5uwjf	166	34	twice	twice	RB
cord-270337-92a5uwjf	166	35	the	the	DT
cord-270337-92a5uwjf	166	36	infusion	infusion	NN
cord-270337-92a5uwjf	166	37	rate	rate	NN
cord-270337-92a5uwjf	166	38	,	,	,
cord-270337-92a5uwjf	166	39	with	with	IN
cord-270337-92a5uwjf	166	40	both	both	DT
cord-270337-92a5uwjf	166	41	groups	group	NNS
cord-270337-92a5uwjf	166	42	receiving	receive	VBG
cord-270337-92a5uwjf	166	43	a	a	DT
cord-270337-92a5uwjf	166	44	total	total	NN
cord-270337-92a5uwjf	166	45	of	of	IN
cord-270337-92a5uwjf	166	46	12	12	CD
cord-270337-92a5uwjf	166	47	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	166	48	−1	−1	NNP
cord-270337-92a5uwjf	166	49	of	of	IN
cord-270337-92a5uwjf	166	50	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	166	51	over	over	IN
cord-270337-92a5uwjf	166	52	these	these	DT
cord-270337-92a5uwjf	166	53	periods	period	NNS
cord-270337-92a5uwjf	166	54	.	.	.
cord-270337-92a5uwjf	167	1	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	167	2	also	also	RB
cord-270337-92a5uwjf	167	3	caused	cause	VBD
cord-270337-92a5uwjf	167	4	a	a	DT
cord-270337-92a5uwjf	167	5	dose	dose	NN
cord-270337-92a5uwjf	167	6	-	-	HYPH
cord-270337-92a5uwjf	167	7	dependent	dependent	JJ
cord-270337-92a5uwjf	167	8	increase	increase	NN
cord-270337-92a5uwjf	167	9	in	in	IN
cord-270337-92a5uwjf	167	10	the	the	DT
cord-270337-92a5uwjf	167	11	PR	PR	NNP
cord-270337-92a5uwjf	167	12	interval	interval	NN
cord-270337-92a5uwjf	167	13	in	in	IN
cord-270337-92a5uwjf	167	14	rabbits	rabbit	NNS
cord-270337-92a5uwjf	167	15	.	.	.
cord-270337-92a5uwjf	168	1	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	168	2	broadened	broaden	VBD
cord-270337-92a5uwjf	168	3	the	the	DT
cord-270337-92a5uwjf	168	4	QRS	qrs	NN
cord-270337-92a5uwjf	168	5	complex	complex	NN
cord-270337-92a5uwjf	168	6	in	in	IN
cord-270337-92a5uwjf	168	7	all	all	DT
cord-270337-92a5uwjf	168	8	animals	animal	NNS
cord-270337-92a5uwjf	168	9	(	(	-LRB-
cord-270337-92a5uwjf	168	10	Figure	figure	NN
cord-270337-92a5uwjf	168	11	1	1	CD
cord-270337-92a5uwjf	168	12	)	)	-RRB-
cord-270337-92a5uwjf	168	13	,	,	,
cord-270337-92a5uwjf	168	14	although	although	IN
cord-270337-92a5uwjf	168	15	this	this	DT
cord-270337-92a5uwjf	168	16	was	be	VBD
cord-270337-92a5uwjf	168	17	not	not	RB
cord-270337-92a5uwjf	168	18	as	as	RB
cord-270337-92a5uwjf	168	19	pronounced	pronounce	VBN
cord-270337-92a5uwjf	168	20	with	with	IN
cord-270337-92a5uwjf	168	21	the	the	DT
cord-270337-92a5uwjf	168	22	slower	slow	JJR
cord-270337-92a5uwjf	168	23	infusion	infusion	NN
cord-270337-92a5uwjf	168	24	rates	rate	NNS
cord-270337-92a5uwjf	168	25	as	as	IN
cord-270337-92a5uwjf	168	26	the	the	DT
cord-270337-92a5uwjf	168	27	changes	change	NNS
cord-270337-92a5uwjf	168	28	in	in	IN
cord-270337-92a5uwjf	168	29	PR	PR	NNP
cord-270337-92a5uwjf	168	30	duration	duration	NN
cord-270337-92a5uwjf	168	31	.	.	.
cord-270337-92a5uwjf	169	1	In	in	IN
cord-270337-92a5uwjf	169	2	ventilated	ventilate	VBN
cord-270337-92a5uwjf	169	3	rats	rat	NNS
cord-270337-92a5uwjf	169	4	,	,	,
cord-270337-92a5uwjf	169	5	for	for	IN
cord-270337-92a5uwjf	169	6	example	example	NN
cord-270337-92a5uwjf	169	7	,	,	,
cord-270337-92a5uwjf	169	8	the	the	DT
cord-270337-92a5uwjf	169	9	QRS	qrs	NN
cord-270337-92a5uwjf	169	10	duration	duration	NN
cord-270337-92a5uwjf	169	11	increased	increase	VBN
cord-270337-92a5uwjf	169	12	by	by	IN
cord-270337-92a5uwjf	169	13	17	17	CD
cord-270337-92a5uwjf	169	14	%	%	NN
cord-270337-92a5uwjf	169	15	in	in	IN
cord-270337-92a5uwjf	169	16	the	the	DT
cord-270337-92a5uwjf	169	17	first	first	JJ
cord-270337-92a5uwjf	169	18	30	30	CD
cord-270337-92a5uwjf	169	19	min	min	NN
cord-270337-92a5uwjf	169	20	of	of	IN
cord-270337-92a5uwjf	169	21	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	169	22	being	be	VBG
cord-270337-92a5uwjf	169	23	infused	infuse	VBN
cord-270337-92a5uwjf	169	24	at	at	IN
cord-270337-92a5uwjf	169	25	1	1	CD
cord-270337-92a5uwjf	169	26	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	169	27	−1	−1	NNP
cord-270337-92a5uwjf	170	1	Ámin	Ámin	NNP
cord-270337-92a5uwjf	170	2	−1	−1	NNP
cord-270337-92a5uwjf	171	1	while	while	IN
cord-270337-92a5uwjf	171	2	a	a	DT
cord-270337-92a5uwjf	171	3	30	30	CD
cord-270337-92a5uwjf	171	4	%	%	NN
cord-270337-92a5uwjf	171	5	increase	increase	NN
cord-270337-92a5uwjf	171	6	in	in	IN
cord-270337-92a5uwjf	171	7	PR	PR	NNP
cord-270337-92a5uwjf	171	8	interval	interval	NN
cord-270337-92a5uwjf	171	9	occurred	occur	VBD
cord-270337-92a5uwjf	171	10	over	over	IN
cord-270337-92a5uwjf	171	11	the	the	DT
cord-270337-92a5uwjf	171	12	same	same	JJ
cord-270337-92a5uwjf	171	13	period	period	NN
cord-270337-92a5uwjf	171	14	.	.	.
cord-270337-92a5uwjf	172	1	QT	QT	NNP
cord-270337-92a5uwjf	172	2	interval	interval	NN
cord-270337-92a5uwjf	172	3	prolongations	prolongation	NNS
cord-270337-92a5uwjf	172	4	were	be	VBD
cord-270337-92a5uwjf	172	5	observed	observe	VBN
cord-270337-92a5uwjf	172	6	with	with	IN
cord-270337-92a5uwjf	172	7	high	high	JJ
cord-270337-92a5uwjf	172	8	infusion	infusion	NN
cord-270337-92a5uwjf	172	9	rates	rate	NNS
cord-270337-92a5uwjf	172	10	,	,	,
cord-270337-92a5uwjf	172	11	but	but	CC
cord-270337-92a5uwjf	172	12	these	these	DT
cord-270337-92a5uwjf	172	13	were	be	VBD
cord-270337-92a5uwjf	172	14	not	not	RB
cord-270337-92a5uwjf	172	15	as	as	RB
cord-270337-92a5uwjf	172	16	apparent	apparent	JJ
cord-270337-92a5uwjf	172	17	when	when	WRB
cord-270337-92a5uwjf	172	18	the	the	DT
cord-270337-92a5uwjf	172	19	QT	qt	NN
cord-270337-92a5uwjf	172	20	was	be	VBD
cord-270337-92a5uwjf	172	21	corrected	correct	VBN
cord-270337-92a5uwjf	172	22	for	for	IN
cord-270337-92a5uwjf	172	23	rate	rate	NN
cord-270337-92a5uwjf	172	24	effects	effect	NNS
cord-270337-92a5uwjf	172	25	.	.	.
cord-270337-92a5uwjf	173	1	A	a	DT
cord-270337-92a5uwjf	173	2	substantial	substantial	JJ
cord-270337-92a5uwjf	173	3	increase	increase	NN
cord-270337-92a5uwjf	173	4	in	in	IN
cord-270337-92a5uwjf	173	5	QTc	qtc	NN
cord-270337-92a5uwjf	173	6	occurred	occur	VBD
cord-270337-92a5uwjf	173	7	only	only	RB
cord-270337-92a5uwjf	173	8	with	with	IN
cord-270337-92a5uwjf	173	9	2	2	CD
cord-270337-92a5uwjf	173	10	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	173	11	−1	−1	NNP
cord-270337-92a5uwjf	173	12	Ámin	Ámin	NNP
cord-270337-92a5uwjf	173	13	−1	−1	NNP
cord-270337-92a5uwjf	173	14	in	in	IN
cord-270337-92a5uwjf	173	15	ventilated	ventilate	VBN
cord-270337-92a5uwjf	173	16	rats	rat	NNS
cord-270337-92a5uwjf	173	17	.	.	.
cord-270337-92a5uwjf	174	1	Effects	effect	NNS
cord-270337-92a5uwjf	174	2	of	of	IN
cord-270337-92a5uwjf	174	3	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	174	4	(	(	-LRB-
cord-270337-92a5uwjf	174	5	30	30	CD
cord-270337-92a5uwjf	174	6	μM	μM	NNP
cord-270337-92a5uwjf	174	7	)	)	-RRB-
cord-270337-92a5uwjf	174	8	in	in	IN
cord-270337-92a5uwjf	174	9	the	the	DT
cord-270337-92a5uwjf	174	10	presence	presence	NN
cord-270337-92a5uwjf	174	11	of	of	IN
cord-270337-92a5uwjf	174	12	propylene	propylene	NN
cord-270337-92a5uwjf	174	13	glycol	glycol	NN
cord-270337-92a5uwjf	174	14	1	1	CD
cord-270337-92a5uwjf	174	15	%	%	NN
cord-270337-92a5uwjf	174	16	v	v	NN
cord-270337-92a5uwjf	174	17	/	/	SYM
cord-270337-92a5uwjf	174	18	v	v	NN
cord-270337-92a5uwjf	174	19	(	(	-LRB-
cord-270337-92a5uwjf	174	20	control	control	NN
cord-270337-92a5uwjf	174	21	)	)	-RRB-
cord-270337-92a5uwjf	174	22	or	or	CC
cord-270337-92a5uwjf	174	23	diazepam	diazepam	NN
cord-270337-92a5uwjf	174	24	(	(	-LRB-
cord-270337-92a5uwjf	174	25	1	1	CD
cord-270337-92a5uwjf	174	26	,	,	,
cord-270337-92a5uwjf	174	27	10	10	CD
cord-270337-92a5uwjf	174	28	and	and	CC
cord-270337-92a5uwjf	174	29	100	100	CD
cord-270337-92a5uwjf	174	30	μM	μM	NNP
cord-270337-92a5uwjf	174	31	)	)	-RRB-
cord-270337-92a5uwjf	174	32	on	on	IN
cord-270337-92a5uwjf	174	33	the	the	DT
cord-270337-92a5uwjf	174	34	developed	develop	VBN
cord-270337-92a5uwjf	174	35	tension	tension	NN
cord-270337-92a5uwjf	174	36	,	,	,
cord-270337-92a5uwjf	174	37	effective	effective	JJ
cord-270337-92a5uwjf	174	38	refractory	refractory	JJ
cord-270337-92a5uwjf	174	39	period	period	NN
cord-270337-92a5uwjf	174	40	and	and	CC
cord-270337-92a5uwjf	174	41	time	time	NN
cord-270337-92a5uwjf	174	42	to	to	TO
cord-270337-92a5uwjf	174	43	peak	peak	VB
cord-270337-92a5uwjf	174	44	tension	tension	NN
cord-270337-92a5uwjf	174	45	of	of	IN
cord-270337-92a5uwjf	174	46	left	left	JJ
cord-270337-92a5uwjf	174	47	atria	atria	NN
cord-270337-92a5uwjf	174	48	,	,	,
cord-270337-92a5uwjf	174	49	right	right	JJ
cord-270337-92a5uwjf	174	50	ventricular	ventricular	JJ
cord-270337-92a5uwjf	174	51	strips	strip	NNS
cord-270337-92a5uwjf	174	52	,	,	,
cord-270337-92a5uwjf	174	53	right	right	JJ
cord-270337-92a5uwjf	174	54	papillary	papillary	JJ
cord-270337-92a5uwjf	174	55	muscles	muscle	NNS
cord-270337-92a5uwjf	174	56	and	and	CC
cord-270337-92a5uwjf	174	57	on	on	IN
cord-270337-92a5uwjf	174	58	the	the	DT
cord-270337-92a5uwjf	174	59	spontaneous	spontaneous	JJ
cord-270337-92a5uwjf	174	60	beating	beating	NN
cord-270337-92a5uwjf	174	61	rate	rate	NN
cord-270337-92a5uwjf	174	62	of	of	IN
cord-270337-92a5uwjf	174	63	right	right	JJ
cord-270337-92a5uwjf	174	64	atria	atria	NN
cord-270337-92a5uwjf	175	1	In	in	IN
cord-270337-92a5uwjf	175	2	all	all	DT
cord-270337-92a5uwjf	175	3	16	16	CD
cord-270337-92a5uwjf	175	4	rabbits	rabbit	NNS
cord-270337-92a5uwjf	175	5	,	,	,
cord-270337-92a5uwjf	175	6	arrhythmias	arrhythmias	RB
cord-270337-92a5uwjf	175	7	presented	present	VBN
cord-270337-92a5uwjf	175	8	as	as	IN
cord-270337-92a5uwjf	175	9	Mobitz	Mobitz	NNP
cord-270337-92a5uwjf	175	10	type	type	NN
cord-270337-92a5uwjf	175	11	II	II	NNP
cord-270337-92a5uwjf	175	12	,	,	,
cord-270337-92a5uwjf	175	13	seconddegree	seconddegree	NN
cord-270337-92a5uwjf	175	14	AV	av	NN
cord-270337-92a5uwjf	175	15	block	block	NN
cord-270337-92a5uwjf	175	16	with	with	IN
cord-270337-92a5uwjf	175	17	a	a	DT
cord-270337-92a5uwjf	175	18	conduction	conduction	NN
cord-270337-92a5uwjf	175	19	ratio	ratio	NN
cord-270337-92a5uwjf	175	20	of	of	IN
cord-270337-92a5uwjf	175	21	2:1	2:1	CD
cord-270337-92a5uwjf	175	22	(	(	-LRB-
cord-270337-92a5uwjf	175	23	two	two	CD
cord-270337-92a5uwjf	175	24	P	p	NN
cord-270337-92a5uwjf	175	25	waves	wave	NNS
cord-270337-92a5uwjf	175	26	for	for	IN
cord-270337-92a5uwjf	175	27	each	each	DT
cord-270337-92a5uwjf	175	28	QRS	qrs	NN
cord-270337-92a5uwjf	175	29	complex	complex	NN
cord-270337-92a5uwjf	175	30	)	)	-RRB-
cord-270337-92a5uwjf	175	31	.	.	.
cord-270337-92a5uwjf	176	1	The	the	DT
cord-270337-92a5uwjf	176	2	onset	onset	NN
cord-270337-92a5uwjf	176	3	of	of	IN
cord-270337-92a5uwjf	176	4	arrhythmias	arrhythmia	NNS
cord-270337-92a5uwjf	176	5	was	be	VBD
cord-270337-92a5uwjf	176	6	dose	dose	JJ
cord-270337-92a5uwjf	176	7	dependent	dependent	JJ
cord-270337-92a5uwjf	176	8	and	and	CC
cord-270337-92a5uwjf	176	9	with	with	IN
cord-270337-92a5uwjf	176	10	higher	high	JJR
cord-270337-92a5uwjf	176	11	degrees	degree	NNS
cord-270337-92a5uwjf	176	12	of	of	IN
cord-270337-92a5uwjf	176	13	block	block	NN
cord-270337-92a5uwjf	176	14	eventually	eventually	RB
cord-270337-92a5uwjf	176	15	occurring	occur	VBG
cord-270337-92a5uwjf	176	16	at	at	IN
cord-270337-92a5uwjf	176	17	the	the	DT
cord-270337-92a5uwjf	176	18	faster	fast	JJR
cord-270337-92a5uwjf	176	19	infusion	infusion	NN
cord-270337-92a5uwjf	176	20	rates	rate	NNS
cord-270337-92a5uwjf	176	21	.	.	.
cord-270337-92a5uwjf	177	1	These	these	DT
cord-270337-92a5uwjf	177	2	largely	largely	RB
cord-270337-92a5uwjf	177	3	degenerated	degenerate	VBN
cord-270337-92a5uwjf	177	4	to	to	IN
cord-270337-92a5uwjf	177	5	ventricular	ventricular	JJ
cord-270337-92a5uwjf	177	6	tachycardia	tachycardia	NN
cord-270337-92a5uwjf	177	7	and	and	CC
cord-270337-92a5uwjf	177	8	fibrillation	fibrillation	NN
cord-270337-92a5uwjf	177	9	.	.	.
cord-270337-92a5uwjf	178	1	i	i	PRP
cord-270337-92a5uwjf	178	2	Efficacy	Efficacy	NNP
cord-270337-92a5uwjf	178	3	of	of	IN
cord-270337-92a5uwjf	178	4	ligands	ligand	NNS
cord-270337-92a5uwjf	178	5	for	for	IN
cord-270337-92a5uwjf	178	6	benzodiazepine	benzodiazepine	NN
cord-270337-92a5uwjf	178	7	binding	bind	VBG
cord-270337-92a5uwjf	178	8	sites	site	NNS
cord-270337-92a5uwjf	178	9	(	(	-LRB-
cord-270337-92a5uwjf	178	10	before	before	IN
cord-270337-92a5uwjf	178	11	infusion	infusion	NN
cord-270337-92a5uwjf	178	12	of	of	IN
cord-270337-92a5uwjf	178	13	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	178	14	)	)	-RRB-
cord-270337-92a5uwjf	179	1	Twenty	twenty	CD
cord-270337-92a5uwjf	179	2	-	-	HYPH
cord-270337-92a5uwjf	179	3	seven	seven	CD
cord-270337-92a5uwjf	179	4	rats	rat	NNS
cord-270337-92a5uwjf	179	5	entered	enter	VBN
cord-270337-92a5uwjf	179	6	in	in	IN
cord-270337-92a5uwjf	179	7	the	the	DT
cord-270337-92a5uwjf	179	8	study	study	NN
cord-270337-92a5uwjf	179	9	,	,	,
cord-270337-92a5uwjf	179	10	but	but	CC
cord-270337-92a5uwjf	179	11	three	three	CD
cord-270337-92a5uwjf	179	12	died	die	VBD
cord-270337-92a5uwjf	179	13	immediately	immediately	RB
cord-270337-92a5uwjf	179	14	following	follow	VBG
cord-270337-92a5uwjf	179	15	the	the	DT
cord-270337-92a5uwjf	179	16	administration	administration	NN
cord-270337-92a5uwjf	179	17	of	of	IN
cord-270337-92a5uwjf	179	18	clonazepam	clonazepam	NNP
cord-270337-92a5uwjf	179	19	and	and	CC
cord-270337-92a5uwjf	179	20	were	be	VBD
cord-270337-92a5uwjf	179	21	excluded	exclude	VBN
cord-270337-92a5uwjf	179	22	.	.	.
cord-270337-92a5uwjf	180	1	There	there	EX
cord-270337-92a5uwjf	180	2	were	be	VBD
cord-270337-92a5uwjf	180	3	no	no	DT
cord-270337-92a5uwjf	180	4	differences	difference	NNS
cord-270337-92a5uwjf	180	5	between	between	IN
cord-270337-92a5uwjf	180	6	pre	pre	JJ
cord-270337-92a5uwjf	180	7	-	-	NN
cord-270337-92a5uwjf	180	8	and	and	CC
cord-270337-92a5uwjf	180	9	10	10	CD
cord-270337-92a5uwjf	180	10	min	min	NN
cord-270337-92a5uwjf	180	11	post	post	JJ
cord-270337-92a5uwjf	180	12	-	-	JJ
cord-270337-92a5uwjf	180	13	drug	drug	JJ
cord-270337-92a5uwjf	180	14	haemodynamics	haemodynamic	NNS
cord-270337-92a5uwjf	180	15	or	or	CC
cord-270337-92a5uwjf	180	16	ECG	ECG	NNP
cord-270337-92a5uwjf	180	17	parameters	parameter	NNS
cord-270337-92a5uwjf	180	18	or	or	CC
cord-270337-92a5uwjf	180	19	between	between	IN
cord-270337-92a5uwjf	180	20	randomised	randomised	JJ
cord-270337-92a5uwjf	180	21	groups	group	NNS
cord-270337-92a5uwjf	180	22	with	with	IN
cord-270337-92a5uwjf	180	23	the	the	DT
cord-270337-92a5uwjf	180	24	administration	administration	NN
cord-270337-92a5uwjf	180	25	of	of	IN
cord-270337-92a5uwjf	180	26	diazepam	diazepam	NNP
cord-270337-92a5uwjf	180	27	,	,	,
cord-270337-92a5uwjf	180	28	clonazepam	clonazepam	NN
cord-270337-92a5uwjf	180	29	,	,	,
cord-270337-92a5uwjf	180	30	Ro5	ro5	CD
cord-270337-92a5uwjf	180	31	-	-	HYPH
cord-270337-92a5uwjf	180	32	4864	4864	CD
cord-270337-92a5uwjf	180	33	,	,	,
cord-270337-92a5uwjf	180	34	or	or	CC
cord-270337-92a5uwjf	180	35	vehicle	vehicle	NN
cord-270337-92a5uwjf	180	36	.	.	.
cord-270337-92a5uwjf	181	1	In	in	IN
cord-270337-92a5uwjf	181	2	the	the	DT
cord-270337-92a5uwjf	181	3	presence	presence	NN
cord-270337-92a5uwjf	181	4	of	of	IN
cord-270337-92a5uwjf	181	5	these	these	DT
cord-270337-92a5uwjf	181	6	agents	agent	NNS
cord-270337-92a5uwjf	181	7	,	,	,
cord-270337-92a5uwjf	181	8	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	181	9	reduced	reduce	VBD
cord-270337-92a5uwjf	181	10	BP	BP	NNP
cord-270337-92a5uwjf	181	11	,	,	,
cord-270337-92a5uwjf	181	12	heart	heart	NN
cord-270337-92a5uwjf	181	13	rate	rate	NN
cord-270337-92a5uwjf	181	14	,	,	,
cord-270337-92a5uwjf	181	15	contractility	contractility	NN
cord-270337-92a5uwjf	181	16	index	index	NN
cord-270337-92a5uwjf	181	17	and	and	CC
cord-270337-92a5uwjf	181	18	increased	increase	VBD
cord-270337-92a5uwjf	181	19	the	the	DT
cord-270337-92a5uwjf	181	20	PR	pr	NN
cord-270337-92a5uwjf	181	21	,	,	,
cord-270337-92a5uwjf	181	22	QRS	QRS	NNP
cord-270337-92a5uwjf	181	23	and	and	CC
cord-270337-92a5uwjf	181	24	QTc	QTc	NNP
cord-270337-92a5uwjf	181	25	intervals	interval	NNS
cord-270337-92a5uwjf	182	1	(	(	-LRB-
cord-270337-92a5uwjf	182	2	Note	note	NN
cord-270337-92a5uwjf	182	3	:	:	:
cord-270337-92a5uwjf	183	1	Data	datum	NNS
cord-270337-92a5uwjf	183	2	are	be	VBP
cord-270337-92a5uwjf	184	1	mean	mean	VB
cord-270337-92a5uwjf	184	2	±	±	NNP
cord-270337-92a5uwjf	184	3	SEM	SEM	NNP
cord-270337-92a5uwjf	184	4	,	,	,
cord-270337-92a5uwjf	184	5	of	of	IN
cord-270337-92a5uwjf	184	6	time	time	NN
cord-270337-92a5uwjf	184	7	-	-	HYPH
cord-270337-92a5uwjf	184	8	averaged	average	VBN
cord-270337-92a5uwjf	184	9	measurements	measurement	NNS
cord-270337-92a5uwjf	184	10	taken	take	VBN
cord-270337-92a5uwjf	184	11	over	over	RP
cord-270337-92a5uwjf	184	12	15	15	CD
cord-270337-92a5uwjf	184	13	min	min	NN
cord-270337-92a5uwjf	184	14	during	during	IN
cord-270337-92a5uwjf	184	15	administration	administration	NN
cord-270337-92a5uwjf	184	16	of	of	IN
cord-270337-92a5uwjf	184	17	chloroquine	chloroquine	NNP
cord-270337-92a5uwjf	184	18	in	in	IN
cord-270337-92a5uwjf	184	19	trial	trial	NN
cord-270337-92a5uwjf	184	20	(	(	-LRB-
cord-270337-92a5uwjf	184	21	i	i	NN
cord-270337-92a5uwjf	184	22	)	)	-RRB-
cord-270337-92a5uwjf	184	23	,	,	,
cord-270337-92a5uwjf	184	24	and	and	CC
cord-270337-92a5uwjf	184	25	over	over	IN
cord-270337-92a5uwjf	184	26	30	30	CD
cord-270337-92a5uwjf	184	27	min	min	NN
cord-270337-92a5uwjf	184	28	following	follow	VBG
cord-270337-92a5uwjf	184	29	administration	administration	NN
cord-270337-92a5uwjf	184	30	of	of	IN
cord-270337-92a5uwjf	184	31	drug	drug	NN
cord-270337-92a5uwjf	184	32	trestments	trestment	NNS
cord-270337-92a5uwjf	184	33	in	in	IN
cord-270337-92a5uwjf	184	34	trials	trial	NNS
cord-270337-92a5uwjf	184	35	(	(	-LRB-
cord-270337-92a5uwjf	184	36	ii	ii	NN
cord-270337-92a5uwjf	184	37	)	)	-RRB-
cord-270337-92a5uwjf	184	38	to	to	IN
cord-270337-92a5uwjf	184	39	(	(	-LRB-
cord-270337-92a5uwjf	184	40	vi	vi	NNP
cord-270337-92a5uwjf	184	41	)	)	-RRB-
cord-270337-92a5uwjf	184	42	.	.	.
cord-270337-92a5uwjf	185	1	a	a	DT
cord-270337-92a5uwjf	185	2	[	[	-LRB-
cord-270337-92a5uwjf	185	3	+	+	SYM
cord-270337-92a5uwjf	185	4	dP	dp	NN
cord-270337-92a5uwjf	185	5	/	/	SYM
cord-270337-92a5uwjf	185	6	dtmax	dtmax	NNP
cord-270337-92a5uwjf	185	7	/	/	SYM
cord-270337-92a5uwjf	185	8	P	p	NN
cord-270337-92a5uwjf	185	9	]	]	-RRB-
cord-270337-92a5uwjf	185	10	was	be	VBD
cord-270337-92a5uwjf	185	11	measured	measure	VBN
cord-270337-92a5uwjf	185	12	in	in	IN
cord-270337-92a5uwjf	185	13	each	each	DT
cord-270337-92a5uwjf	185	14	experiment	experiment	NN
cord-270337-92a5uwjf	185	15	with	with	IN
cord-270337-92a5uwjf	185	16	the	the	DT
cord-270337-92a5uwjf	185	17	exception	exception	NN
cord-270337-92a5uwjf	185	18	of	of	IN
cord-270337-92a5uwjf	185	19	experiment	experiment	NN
cord-270337-92a5uwjf	185	20	(	(	-LRB-
cord-270337-92a5uwjf	185	21	v	v	NN
cord-270337-92a5uwjf	185	22	)	)	-RRB-
cord-270337-92a5uwjf	185	23	,	,	,
cord-270337-92a5uwjf	185	24	which	which	WDT
cord-270337-92a5uwjf	185	25	measured	measure	VBD
cord-270337-92a5uwjf	185	26	[	[	-LRB-
cord-270337-92a5uwjf	185	27	+	+	CC
cord-270337-92a5uwjf	185	28	dP	dp	NN
cord-270337-92a5uwjf	185	29	/	/	SYM
cord-270337-92a5uwjf	185	30	dtmax	dtmax	NNP
cord-270337-92a5uwjf	185	31	]	]	-RRB-
cord-270337-92a5uwjf	185	32	.	.	.
cord-270337-92a5uwjf	186	1	*	*	NFP
cord-270337-92a5uwjf	186	2	P	p	XX
cord-270337-92a5uwjf	186	3	<	<	XX
cord-270337-92a5uwjf	186	4	0.05	0.05	CD
cord-270337-92a5uwjf	186	5	versus	versus	IN
cord-270337-92a5uwjf	186	6	control	control	NNP
cord-270337-92a5uwjf	186	7	group	group	NN
cord-270337-92a5uwjf	186	8	.	.	.
cord-270337-92a5uwjf	187	1	iv	iv	LS
cord-270337-92a5uwjf	188	1	Efficacy	efficacy	NN
cord-270337-92a5uwjf	188	2	of	of	IN
cord-270337-92a5uwjf	188	3	high	high	JJ
cord-270337-92a5uwjf	188	4	dose	dose	NN
cord-270337-92a5uwjf	188	5	diazepam	diazepam	NN
cord-270337-92a5uwjf	188	6	(	(	-LRB-
cord-270337-92a5uwjf	188	7	during	during	IN
cord-270337-92a5uwjf	188	8	infusion	infusion	NN
cord-270337-92a5uwjf	188	9	of	of	IN
cord-270337-92a5uwjf	188	10	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	188	11	)	)	-RRB-
cord-270337-92a5uwjf	189	1	In	in	IN
cord-270337-92a5uwjf	189	2	contrast	contrast	NN
cord-270337-92a5uwjf	189	3	to	to	IN
cord-270337-92a5uwjf	189	4	trial	trial	NN
cord-270337-92a5uwjf	189	5	(	(	-LRB-
cord-270337-92a5uwjf	189	6	ii	ii	NN
cord-270337-92a5uwjf	189	7	)	)	-RRB-
cord-270337-92a5uwjf	189	8	,	,	,
cord-270337-92a5uwjf	189	9	an	an	DT
cord-270337-92a5uwjf	189	10	infusion	infusion	NN
cord-270337-92a5uwjf	189	11	of	of	IN
cord-270337-92a5uwjf	189	12	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	189	13	for	for	IN
cord-270337-92a5uwjf	189	14	30	30	CD
cord-270337-92a5uwjf	189	15	min	min	NN
cord-270337-92a5uwjf	189	16	did	do	VBD
cord-270337-92a5uwjf	189	17	not	not	RB
cord-270337-92a5uwjf	189	18	cause	cause	VB
cord-270337-92a5uwjf	189	19	significant	significant	JJ
cord-270337-92a5uwjf	189	20	changes	change	NNS
cord-270337-92a5uwjf	189	21	in	in	IN
cord-270337-92a5uwjf	189	22	any	any	DT
cord-270337-92a5uwjf	189	23	of	of	IN
cord-270337-92a5uwjf	189	24	the	the	DT
cord-270337-92a5uwjf	189	25	haemodynamic	haemodynamic	JJ
cord-270337-92a5uwjf	189	26	or	or	CC
cord-270337-92a5uwjf	189	27	ECG	ECG	NNP
cord-270337-92a5uwjf	189	28	parameters	parameter	NNS
cord-270337-92a5uwjf	189	29	.	.	.
cord-270337-92a5uwjf	190	1	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	190	2	did	do	VBD
cord-270337-92a5uwjf	190	3	not	not	RB
cord-270337-92a5uwjf	190	4	reduce	reduce	VB
cord-270337-92a5uwjf	190	5	mean	mean	JJ
cord-270337-92a5uwjf	190	6	BP	BP	NNP
cord-270337-92a5uwjf	190	7	and	and	CC
cord-270337-92a5uwjf	190	8	heart	heart	NN
cord-270337-92a5uwjf	190	9	rate	rate	NN
cord-270337-92a5uwjf	190	10	or	or	CC
cord-270337-92a5uwjf	190	11	increase	increase	VB
cord-270337-92a5uwjf	190	12	the	the	DT
cord-270337-92a5uwjf	190	13	QTc	qtc	NN
cord-270337-92a5uwjf	190	14	interval	interval	NN
cord-270337-92a5uwjf	190	15	significantly	significantly	RB
cord-270337-92a5uwjf	190	16	in	in	IN
cord-270337-92a5uwjf	190	17	those	those	DT
cord-270337-92a5uwjf	190	18	randomised	randomised	JJ
cord-270337-92a5uwjf	190	19	to	to	TO
cord-270337-92a5uwjf	190	20	diazepam	diazepam	VB
cord-270337-92a5uwjf	190	21	and	and	CC
cord-270337-92a5uwjf	190	22	did	do	VBD
cord-270337-92a5uwjf	190	23	not	not	RB
cord-270337-92a5uwjf	190	24	increase	increase	VB
cord-270337-92a5uwjf	190	25	the	the	DT
cord-270337-92a5uwjf	190	26	QRS	qrs	NN
cord-270337-92a5uwjf	190	27	interval	interval	NN
cord-270337-92a5uwjf	190	28	in	in	IN
cord-270337-92a5uwjf	190	29	either	either	DT
cord-270337-92a5uwjf	190	30	group	group	NN
cord-270337-92a5uwjf	190	31	.	.	.
cord-270337-92a5uwjf	191	1	Following	follow	VBG
cord-270337-92a5uwjf	191	2	treatment	treatment	NN
cord-270337-92a5uwjf	191	3	,	,	,
cord-270337-92a5uwjf	191	4	heart	heart	NN
cord-270337-92a5uwjf	191	5	rate	rate	NN
cord-270337-92a5uwjf	191	6	increased	increase	VBD
cord-270337-92a5uwjf	191	7	significantly	significantly	RB
cord-270337-92a5uwjf	191	8	in	in	IN
cord-270337-92a5uwjf	191	9	the	the	DT
cord-270337-92a5uwjf	191	10	diazepam	diazepam	NN
cord-270337-92a5uwjf	191	11	group	group	NN
cord-270337-92a5uwjf	191	12	.	.	.
cord-270337-92a5uwjf	192	1	There	there	EX
cord-270337-92a5uwjf	192	2	were	be	VBD
cord-270337-92a5uwjf	192	3	no	no	DT
cord-270337-92a5uwjf	192	4	differences	difference	NNS
cord-270337-92a5uwjf	192	5	between	between	IN
cord-270337-92a5uwjf	192	6	treatment	treatment	NN
cord-270337-92a5uwjf	192	7	groups	group	NNS
cord-270337-92a5uwjf	192	8	in	in	IN
cord-270337-92a5uwjf	192	9	other	other	JJ
cord-270337-92a5uwjf	192	10	parameters	parameter	NNS
cord-270337-92a5uwjf	192	11	and	and	CC
cord-270337-92a5uwjf	192	12	none	none	NN
cord-270337-92a5uwjf	192	13	developed	develop	VBD
cord-270337-92a5uwjf	192	14	arrhythmias	arrhythmia	NNS
cord-270337-92a5uwjf	192	15	(	(	-LRB-
cord-270337-92a5uwjf	192	16	Table	Table	NNP
cord-270337-92a5uwjf	192	17	3	3	CD
cord-270337-92a5uwjf	192	18	)	)	-RRB-
cord-270337-92a5uwjf	192	19	.	.	.
cord-270337-92a5uwjf	193	1	The	the	DT
cord-270337-92a5uwjf	193	2	whole	whole	JJ
cord-270337-92a5uwjf	193	3	blood	blood	NN
cord-270337-92a5uwjf	193	4	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	193	5	concentration	concentration	NN
cord-270337-92a5uwjf	193	6	in	in	IN
cord-270337-92a5uwjf	193	7	these	these	DT
cord-270337-92a5uwjf	193	8	rats	rat	NNS
cord-270337-92a5uwjf	193	9	was	be	VBD
cord-270337-92a5uwjf	194	1	12.2	12.2	CD
cord-270337-92a5uwjf	194	2	±	±	CD
cord-270337-92a5uwjf	194	3	0.8	0.8	CD
cord-270337-92a5uwjf	194	4	μM	μm	NN
cord-270337-92a5uwjf	194	5	after	after	IN
cord-270337-92a5uwjf	194	6	25	25	CD
cord-270337-92a5uwjf	194	7	min	min	NN
cord-270337-92a5uwjf	194	8	of	of	IN
cord-270337-92a5uwjf	194	9	infusion	infusion	NN
cord-270337-92a5uwjf	194	10	(	(	-LRB-
cord-270337-92a5uwjf	194	11	1	1	CD
cord-270337-92a5uwjf	194	12	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	194	13	−1	−1	NNP
cord-270337-92a5uwjf	194	14	Ámin	Ámin	NNP
cord-270337-92a5uwjf	194	15	−1	−1	NNP
cord-270337-92a5uwjf	194	16	)	)	-RRB-
cord-270337-92a5uwjf	194	17	,	,	,
cord-270337-92a5uwjf	194	18	14.3	14.3	CD
cord-270337-92a5uwjf	194	19	±	±	CD
cord-270337-92a5uwjf	194	20	0.9	0.9	CD
cord-270337-92a5uwjf	195	1	μM	μM	NNP
cord-270337-92a5uwjf	195	2	after	after	IN
cord-270337-92a5uwjf	195	3	45	45	CD
cord-270337-92a5uwjf	195	4	min	min	NN
cord-270337-92a5uwjf	195	5	and	and	CC
cord-270337-92a5uwjf	195	6	16.3	16.3	CD
cord-270337-92a5uwjf	195	7	±	±	CD
cord-270337-92a5uwjf	195	8	1.1	1.1	CD
cord-270337-92a5uwjf	196	1	μM	μM	NNP
cord-270337-92a5uwjf	196	2	after	after	IN
cord-270337-92a5uwjf	196	3	60	60	CD
cord-270337-92a5uwjf	196	4	min	min	NN
cord-270337-92a5uwjf	196	5	.	.	.
cord-270337-92a5uwjf	197	1	v	v	LS
cord-270337-92a5uwjf	197	2	Efficacy	Efficacy	NNP
cord-270337-92a5uwjf	197	3	of	of	IN
cord-270337-92a5uwjf	197	4	diazepam	diazepam	NN
cord-270337-92a5uwjf	198	1	(	(	-LRB-
cord-270337-92a5uwjf	198	2	during	during	IN
cord-270337-92a5uwjf	198	3	infusion	infusion	NN
cord-270337-92a5uwjf	198	4	of	of	IN
cord-270337-92a5uwjf	198	5	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	198	6	)	)	-RRB-
cord-270337-92a5uwjf	198	7	with	with	IN
cord-270337-92a5uwjf	198	8	a	a	DT
cord-270337-92a5uwjf	198	9	nonbarbiturate	nonbarbiturate	NNP
cord-270337-92a5uwjf	198	10	anaesthetic	anaesthetic	NN
cord-270337-92a5uwjf	198	11	(	(	-LRB-
cord-270337-92a5uwjf	198	12	urethane	urethane	NN
cord-270337-92a5uwjf	198	13	)	)	-RRB-
cord-270337-92a5uwjf	198	14	Over	over	IN
cord-270337-92a5uwjf	198	15	30	30	CD
cord-270337-92a5uwjf	198	16	min	min	NN
cord-270337-92a5uwjf	198	17	of	of	IN
cord-270337-92a5uwjf	198	18	administration	administration	NN
cord-270337-92a5uwjf	198	19	,	,	,
cord-270337-92a5uwjf	198	20	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	198	21	only	only	RB
cord-270337-92a5uwjf	198	22	significantly	significantly	RB
cord-270337-92a5uwjf	198	23	affected	affect	VBD
cord-270337-92a5uwjf	198	24	the	the	DT
cord-270337-92a5uwjf	198	25	PR	pr	NN
cord-270337-92a5uwjf	198	26	and	and	CC
cord-270337-92a5uwjf	198	27	QRS	QRS	NNP
cord-270337-92a5uwjf	198	28	intervals	interval	NNS
cord-270337-92a5uwjf	198	29	.	.	.
cord-270337-92a5uwjf	199	1	There	there	EX
cord-270337-92a5uwjf	199	2	were	be	VBD
cord-270337-92a5uwjf	199	3	no	no	DT
cord-270337-92a5uwjf	199	4	subsequent	subsequent	JJ
cord-270337-92a5uwjf	199	5	differences	difference	NNS
cord-270337-92a5uwjf	199	6	between	between	IN
cord-270337-92a5uwjf	199	7	groups	group	NNS
cord-270337-92a5uwjf	199	8	,	,	,
cord-270337-92a5uwjf	199	9	following	follow	VBG
cord-270337-92a5uwjf	199	10	administration	administration	NN
cord-270337-92a5uwjf	199	11	of	of	IN
cord-270337-92a5uwjf	199	12	diazepam	diazepam	NNP
cord-270337-92a5uwjf	199	13	or	or	CC
cord-270337-92a5uwjf	199	14	vehicle	vehicle	NN
cord-270337-92a5uwjf	199	15	control	control	NN
cord-270337-92a5uwjf	199	16	,	,	,
cord-270337-92a5uwjf	199	17	in	in	IN
cord-270337-92a5uwjf	199	18	any	any	DT
cord-270337-92a5uwjf	199	19	of	of	IN
cord-270337-92a5uwjf	199	20	the	the	DT
cord-270337-92a5uwjf	199	21	measured	measure	VBN
cord-270337-92a5uwjf	199	22	parameters	parameter	NNS
cord-270337-92a5uwjf	199	23	and	and	CC
cord-270337-92a5uwjf	199	24	none	none	NN
cord-270337-92a5uwjf	199	25	developed	develop	VBD
cord-270337-92a5uwjf	199	26	arrhythmias	arrhythmia	NNS
cord-270337-92a5uwjf	199	27	(	(	-LRB-
cord-270337-92a5uwjf	199	28	Table	Table	NNP
cord-270337-92a5uwjf	199	29	3	3	CD
cord-270337-92a5uwjf	199	30	)	)	-RRB-
cord-270337-92a5uwjf	199	31	.	.	.
cord-270337-92a5uwjf	200	1	A	a	DT
cord-270337-92a5uwjf	200	2	further	further	JJ
cord-270337-92a5uwjf	200	3	randomised	randomised	JJ
cord-270337-92a5uwjf	200	4	trial	trial	NN
cord-270337-92a5uwjf	200	5	was	be	VBD
cord-270337-92a5uwjf	200	6	initiated	initiate	VBN
cord-270337-92a5uwjf	200	7	with	with	IN
cord-270337-92a5uwjf	200	8	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	200	9	infused	infuse	VBN
cord-270337-92a5uwjf	200	10	at	at	IN
cord-270337-92a5uwjf	200	11	a	a	DT
cord-270337-92a5uwjf	200	12	higher	high	JJR
cord-270337-92a5uwjf	200	13	rate	rate	NN
cord-270337-92a5uwjf	200	14	of	of	IN
cord-270337-92a5uwjf	200	15	2	2	CD
cord-270337-92a5uwjf	200	16	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	200	17	−1	−1	NNP
cord-270337-92a5uwjf	201	1	Ámin	Ámin	NNP
cord-270337-92a5uwjf	201	2	−1	−1	NNP
cord-270337-92a5uwjf	201	3	in	in	IN
cord-270337-92a5uwjf	201	4	order	order	NN
cord-270337-92a5uwjf	201	5	to	to	TO
cord-270337-92a5uwjf	201	6	evaluate	evaluate	VB
cord-270337-92a5uwjf	201	7	the	the	DT
cord-270337-92a5uwjf	201	8	effects	effect	NNS
cord-270337-92a5uwjf	201	9	of	of	IN
cord-270337-92a5uwjf	201	10	diazepam	diazepam	NN
cord-270337-92a5uwjf	201	11	on	on	IN
cord-270337-92a5uwjf	201	12	more	more	RBR
cord-270337-92a5uwjf	201	13	pronounced	pronounced	JJ
cord-270337-92a5uwjf	201	14	toxicity	toxicity	NN
cord-270337-92a5uwjf	201	15	.	.	.
cord-270337-92a5uwjf	202	1	However	however	RB
cord-270337-92a5uwjf	202	2	five	five	CD
cord-270337-92a5uwjf	202	3	of	of	IN
cord-270337-92a5uwjf	202	4	the	the	DT
cord-270337-92a5uwjf	202	5	first	first	JJ
cord-270337-92a5uwjf	202	6	nine	nine	CD
cord-270337-92a5uwjf	202	7	rats	rat	NNS
cord-270337-92a5uwjf	202	8	died	die	VBD
cord-270337-92a5uwjf	202	9	and	and	CC
cord-270337-92a5uwjf	202	10	the	the	DT
cord-270337-92a5uwjf	202	11	study	study	NN
cord-270337-92a5uwjf	202	12	was	be	VBD
cord-270337-92a5uwjf	202	13	terminated	terminate	VBN
cord-270337-92a5uwjf	202	14	.	.	.
cord-270337-92a5uwjf	203	1	vi	vi	NNP
cord-270337-92a5uwjf	203	2	Efficacy	Efficacy	NNP
cord-270337-92a5uwjf	203	3	of	of	IN
cord-270337-92a5uwjf	203	4	diazepam	diazepam	NN
cord-270337-92a5uwjf	203	5	and	and	CC
cord-270337-92a5uwjf	203	6	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	203	7	(	(	-LRB-
cord-270337-92a5uwjf	203	8	during	during	IN
cord-270337-92a5uwjf	203	9	infusion	infusion	NN
cord-270337-92a5uwjf	203	10	of	of	IN
cord-270337-92a5uwjf	203	11	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	203	12	)	)	-RRB-
cord-270337-92a5uwjf	204	1	Twenty	twenty	CD
cord-270337-92a5uwjf	204	2	-	-	HYPH
cord-270337-92a5uwjf	204	3	seven	seven	CD
cord-270337-92a5uwjf	204	4	rats	rat	NNS
cord-270337-92a5uwjf	204	5	was	be	VBD
cord-270337-92a5uwjf	204	6	included	include	VBN
cord-270337-92a5uwjf	204	7	,	,	,
cord-270337-92a5uwjf	204	8	but	but	CC
cord-270337-92a5uwjf	204	9	three	three	CD
cord-270337-92a5uwjf	204	10	died	die	VBD
cord-270337-92a5uwjf	204	11	before	before	IN
cord-270337-92a5uwjf	204	12	the	the	DT
cord-270337-92a5uwjf	204	13	end	end	NN
cord-270337-92a5uwjf	204	14	of	of	IN
cord-270337-92a5uwjf	204	15	the	the	DT
cord-270337-92a5uwjf	204	16	experiment	experiment	NN
cord-270337-92a5uwjf	204	17	,	,	,
cord-270337-92a5uwjf	204	18	one	one	CD
cord-270337-92a5uwjf	204	19	from	from	IN
cord-270337-92a5uwjf	204	20	each	each	DT
cord-270337-92a5uwjf	204	21	of	of	IN
cord-270337-92a5uwjf	204	22	the	the	DT
cord-270337-92a5uwjf	204	23	control	control	NN
cord-270337-92a5uwjf	204	24	,	,	,
cord-270337-92a5uwjf	204	25	diazepam	diazepam	NN
cord-270337-92a5uwjf	204	26	and	and	CC
cord-270337-92a5uwjf	204	27	diazepam	diazepam	NN
cord-270337-92a5uwjf	204	28	+	+	CC
cord-270337-92a5uwjf	204	29	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	204	30	groups	group	NNS
cord-270337-92a5uwjf	204	31	.	.	.
cord-270337-92a5uwjf	205	1	During	during	IN
cord-270337-92a5uwjf	205	2	the	the	DT
cord-270337-92a5uwjf	205	3	first	first	JJ
cord-270337-92a5uwjf	205	4	30	30	CD
cord-270337-92a5uwjf	205	5	min	min	NN
cord-270337-92a5uwjf	205	6	of	of	IN
cord-270337-92a5uwjf	205	7	infusion	infusion	NN
cord-270337-92a5uwjf	205	8	,	,	,
cord-270337-92a5uwjf	205	9	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	205	10	caused	cause	VBD
cord-270337-92a5uwjf	205	11	significant	significant	JJ
cord-270337-92a5uwjf	205	12	changes	change	NNS
cord-270337-92a5uwjf	205	13	in	in	IN
cord-270337-92a5uwjf	205	14	all	all	DT
cord-270337-92a5uwjf	205	15	parameters	parameter	NNS
cord-270337-92a5uwjf	205	16	,	,	,
cord-270337-92a5uwjf	205	17	with	with	IN
cord-270337-92a5uwjf	205	18	the	the	DT
cord-270337-92a5uwjf	205	19	exception	exception	NN
cord-270337-92a5uwjf	205	20	of	of	IN
cord-270337-92a5uwjf	205	21	the	the	DT
cord-270337-92a5uwjf	205	22	QRS	QRS	NNP
cord-270337-92a5uwjf	205	23	and	and	CC
cord-270337-92a5uwjf	205	24	QTc	QTc	NNP
cord-270337-92a5uwjf	205	25	intervals	interval	NNS
cord-270337-92a5uwjf	205	26	in	in	IN
cord-270337-92a5uwjf	205	27	the	the	DT
cord-270337-92a5uwjf	205	28	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	205	29	group	group	NN
cord-270337-92a5uwjf	205	30	.	.	.
cord-270337-92a5uwjf	206	1	The	the	DT
cord-270337-92a5uwjf	206	2	lack	lack	NN
cord-270337-92a5uwjf	206	3	of	of	IN
cord-270337-92a5uwjf	206	4	an	an	DT
cord-270337-92a5uwjf	206	5	effect	effect	NN
cord-270337-92a5uwjf	206	6	with	with	IN
cord-270337-92a5uwjf	206	7	diazepam	diazepam	NN
cord-270337-92a5uwjf	206	8	(	(	-LRB-
cord-270337-92a5uwjf	206	9	2	2	CD
cord-270337-92a5uwjf	206	10	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	206	11	−1	−1	NNP
cord-270337-92a5uwjf	206	12	)	)	-RRB-
cord-270337-92a5uwjf	207	1	alone	alone	JJ
cord-270337-92a5uwjf	207	2	was	be	VBD
cord-270337-92a5uwjf	207	3	consistent	consistent	JJ
cord-270337-92a5uwjf	207	4	with	with	IN
cord-270337-92a5uwjf	207	5	trial	trial	NN
cord-270337-92a5uwjf	207	6	(	(	-LRB-
cord-270337-92a5uwjf	207	7	ii	ii	NN
cord-270337-92a5uwjf	207	8	)	)	-RRB-
cord-270337-92a5uwjf	207	9	.	.	.
cord-270337-92a5uwjf	208	1	The	the	DT
cord-270337-92a5uwjf	208	2	effects	effect	NNS
cord-270337-92a5uwjf	208	3	of	of	IN
cord-270337-92a5uwjf	208	4	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	208	5	alone	alone	RB
cord-270337-92a5uwjf	208	6	did	do	VBD
cord-270337-92a5uwjf	208	7	not	not	RB
cord-270337-92a5uwjf	208	8	deviate	deviate	VB
cord-270337-92a5uwjf	208	9	significantly	significantly	RB
cord-270337-92a5uwjf	208	10	from	from	IN
cord-270337-92a5uwjf	208	11	the	the	DT
cord-270337-92a5uwjf	208	12	control	control	NN
cord-270337-92a5uwjf	208	13	group	group	NN
cord-270337-92a5uwjf	208	14	in	in	IN
cord-270337-92a5uwjf	208	15	any	any	DT
cord-270337-92a5uwjf	208	16	parameter	parameter	NN
cord-270337-92a5uwjf	208	17	other	other	JJ
cord-270337-92a5uwjf	208	18	than	than	IN
cord-270337-92a5uwjf	208	19	the	the	DT
cord-270337-92a5uwjf	208	20	QRS	qrs	NN
cord-270337-92a5uwjf	208	21	interval	interval	NN
cord-270337-92a5uwjf	208	22	,	,	,
cord-270337-92a5uwjf	208	23	but	but	CC
cord-270337-92a5uwjf	208	24	this	this	DT
cord-270337-92a5uwjf	208	25	was	be	VBD
cord-270337-92a5uwjf	208	26	not	not	RB
cord-270337-92a5uwjf	208	27	prolonged	prolong	VBN
cord-270337-92a5uwjf	208	28	following	follow	VBG
cord-270337-92a5uwjf	208	29	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	208	30	(	(	-LRB-
cord-270337-92a5uwjf	208	31	Figure	figure	NN
cord-270337-92a5uwjf	208	32	2	2	CD
cord-270337-92a5uwjf	208	33	)	)	-RRB-
cord-270337-92a5uwjf	208	34	.	.	.
cord-270337-92a5uwjf	209	1	The	the	DT
cord-270337-92a5uwjf	209	2	combined	combined	JJ
cord-270337-92a5uwjf	209	3	administration	administration	NN
cord-270337-92a5uwjf	209	4	of	of	IN
cord-270337-92a5uwjf	209	5	diazepam	diazepam	NNP
cord-270337-92a5uwjf	209	6	and	and	CC
cord-270337-92a5uwjf	209	7	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	209	8	resulted	result	VBD
cord-270337-92a5uwjf	209	9	in	in	IN
cord-270337-92a5uwjf	209	10	an	an	DT
cord-270337-92a5uwjf	209	11	improvement	improvement	NN
cord-270337-92a5uwjf	209	12	of	of	IN
cord-270337-92a5uwjf	209	13	cardiac	cardiac	JJ
cord-270337-92a5uwjf	209	14	contractility	contractility	NN
cord-270337-92a5uwjf	209	15	compared	compare	VBN
cord-270337-92a5uwjf	209	16	to	to	IN
cord-270337-92a5uwjf	209	17	the	the	DT
cord-270337-92a5uwjf	209	18	control	control	NN
cord-270337-92a5uwjf	209	19	and	and	CC
cord-270337-92a5uwjf	209	20	diazepam	diazepam	NN
cord-270337-92a5uwjf	209	21	groups	group	NNS
cord-270337-92a5uwjf	209	22	but	but	CC
cord-270337-92a5uwjf	209	23	not	not	RB
cord-270337-92a5uwjf	209	24	the	the	DT
cord-270337-92a5uwjf	209	25	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	209	26	group	group	NN
cord-270337-92a5uwjf	209	27	(	(	-LRB-
cord-270337-92a5uwjf	210	1	84	84	CD
cord-270337-92a5uwjf	210	2	±	±	CD
cord-270337-92a5uwjf	210	3	3	3	CD
cord-270337-92a5uwjf	210	4	vs.	vs.	NN
cord-270337-92a5uwjf	210	5	78	78	CD
cord-270337-92a5uwjf	210	6	±	±	NNP
cord-270337-92a5uwjf	210	7	8	8	CD
cord-270337-92a5uwjf	210	8	s	s	NNP
cord-270337-92a5uwjf	210	9	−1	−1	NNP
cord-270337-92a5uwjf	210	10	)	)	-RRB-
cord-270337-92a5uwjf	210	11	.	.	.
cord-270337-92a5uwjf	211	1	No	no	DT
cord-270337-92a5uwjf	211	2	significant	significant	JJ
cord-270337-92a5uwjf	211	3	differences	difference	NNS
cord-270337-92a5uwjf	211	4	were	be	VBD
cord-270337-92a5uwjf	211	5	observed	observe	VBN
cord-270337-92a5uwjf	211	6	in	in	IN
cord-270337-92a5uwjf	211	7	the	the	DT
cord-270337-92a5uwjf	211	8	other	other	JJ
cord-270337-92a5uwjf	211	9	parameters	parameter	NNS
cord-270337-92a5uwjf	211	10	or	or	CC
cord-270337-92a5uwjf	211	11	incidence	incidence	NN
cord-270337-92a5uwjf	211	12	of	of	IN
cord-270337-92a5uwjf	211	13	arrhythmias	arrhythmia	NNS
cord-270337-92a5uwjf	211	14	(	(	-LRB-
cord-270337-92a5uwjf	211	15	Table	Table	NNP
cord-270337-92a5uwjf	211	16	3	3	CD
cord-270337-92a5uwjf	211	17	)	)	-RRB-
cord-270337-92a5uwjf	211	18	.	.	.
cord-270337-92a5uwjf	212	1	Pre	pre	JJ
cord-270337-92a5uwjf	212	2	-	-	JJ
cord-270337-92a5uwjf	212	3	chloroquine	chloroquine	JJ
cord-270337-92a5uwjf	212	4	potassium	potassium	NN
cord-270337-92a5uwjf	212	5	concentrations	concentration	NNS
cord-270337-92a5uwjf	212	6	were	be	VBD
cord-270337-92a5uwjf	212	7	in	in	IN
cord-270337-92a5uwjf	212	8	the	the	DT
cord-270337-92a5uwjf	212	9	range	range	NN
cord-270337-92a5uwjf	212	10	expected	expect	VBN
cord-270337-92a5uwjf	212	11	for	for	IN
cord-270337-92a5uwjf	212	12	rats	rat	NNS
cord-270337-92a5uwjf	212	13	(	(	-LRB-
cord-270337-92a5uwjf	212	14	Burns	Burns	NNP
cord-270337-92a5uwjf	212	15	&	&	CC
cord-270337-92a5uwjf	212	16	De	De	NNP
cord-270337-92a5uwjf	212	17	Lannoy	Lannoy	NNP
cord-270337-92a5uwjf	212	18	,	,	,
cord-270337-92a5uwjf	212	19	1966	1966	CD
cord-270337-92a5uwjf	212	20	)	)	-RRB-
cord-270337-92a5uwjf	212	21	.	.	.
cord-270337-92a5uwjf	213	1	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	213	2	alone	alone	RB
cord-270337-92a5uwjf	213	3	did	do	VBD
cord-270337-92a5uwjf	213	4	not	not	RB
cord-270337-92a5uwjf	213	5	cause	cause	VB
cord-270337-92a5uwjf	213	6	any	any	DT
cord-270337-92a5uwjf	213	7	significant	significant	JJ
cord-270337-92a5uwjf	213	8	changes	change	NNS
cord-270337-92a5uwjf	213	9	in	in	IN
cord-270337-92a5uwjf	213	10	arterial	arterial	JJ
cord-270337-92a5uwjf	213	11	PO	PO	NNP
cord-270337-92a5uwjf	213	12	2	2	CD
cord-270337-92a5uwjf	213	13	,	,	,
cord-270337-92a5uwjf	213	14	PCO	PCO	NNP
cord-270337-92a5uwjf	213	15	2	2	CD
cord-270337-92a5uwjf	213	16	or	or	CC
cord-270337-92a5uwjf	213	17	pH	pH	NNP
cord-270337-92a5uwjf	213	18	values	value	NNS
cord-270337-92a5uwjf	213	19	over	over	IN
cord-270337-92a5uwjf	213	20	a	a	DT
cord-270337-92a5uwjf	213	21	period	period	NN
cord-270337-92a5uwjf	213	22	of	of	IN
cord-270337-92a5uwjf	213	23	30-min	30-min	CD
cord-270337-92a5uwjf	213	24	infusion	infusion	NN
cord-270337-92a5uwjf	213	25	.	.	.
cord-270337-92a5uwjf	214	1	The	the	DT
cord-270337-92a5uwjf	214	2	combined	combined	JJ
cord-270337-92a5uwjf	214	3	administration	administration	NN
cord-270337-92a5uwjf	214	4	of	of	IN
cord-270337-92a5uwjf	214	5	diazepam	diazepam	NN
cord-270337-92a5uwjf	214	6	and	and	CC
cord-270337-92a5uwjf	214	7	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	214	8	,	,	,
cord-270337-92a5uwjf	214	9	however	however	RB
cord-270337-92a5uwjf	214	10	reduced	reduce	VBN
cord-270337-92a5uwjf	214	11	PO	po	NN
cord-270337-92a5uwjf	214	12	2	2	CD
cord-270337-92a5uwjf	214	13	when	when	WRB
cord-270337-92a5uwjf	214	14	compared	compare	VBN
cord-270337-92a5uwjf	214	15	to	to	IN
cord-270337-92a5uwjf	215	1	T	T	NNP
cord-270337-92a5uwjf	215	2	A	a	NN
cord-270337-92a5uwjf	216	1	B	b	NN
cord-270337-92a5uwjf	217	1	L	l	NN
cord-270337-92a5uwjf	217	2	E	E	NNP
cord-270337-92a5uwjf	217	3	4	4	CD
cord-270337-92a5uwjf	218	1	Whole	whole	JJ
cord-270337-92a5uwjf	218	2	blood	blood	NN
cord-270337-92a5uwjf	219	1	pH	pH	NNP
cord-270337-92a5uwjf	219	2	,	,	,
cord-270337-92a5uwjf	219	3	gas	gas	NN
cord-270337-92a5uwjf	219	4	,	,	,
cord-270337-92a5uwjf	219	5	and	and	CC
cord-270337-92a5uwjf	219	6	electrolyte	electrolyte	JJ
cord-270337-92a5uwjf	219	7	concentrations	concentration	NNS
cord-270337-92a5uwjf	219	8	measured	measure	VBN
cord-270337-92a5uwjf	219	9	at	at	IN
cord-270337-92a5uwjf	219	10	baseline	baseline	NN
cord-270337-92a5uwjf	219	11	(	(	-LRB-
cord-270337-92a5uwjf	219	12	pre	pre	JJ
cord-270337-92a5uwjf	219	13	-	-	JJ
cord-270337-92a5uwjf	219	14	chloroquine	chloroquine	JJ
cord-270337-92a5uwjf	219	15	)	)	-RRB-
cord-270337-92a5uwjf	219	16	,	,	,
cord-270337-92a5uwjf	219	17	following	follow	VBG
cord-270337-92a5uwjf	219	18	30	30	CD
cord-270337-92a5uwjf	219	19	min	min	NN
cord-270337-92a5uwjf	219	20	of	of	IN
cord-270337-92a5uwjf	219	21	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	219	22	infusion	infusion	NN
cord-270337-92a5uwjf	219	23	(	(	-LRB-
cord-270337-92a5uwjf	219	24	pre	pre	JJ
cord-270337-92a5uwjf	219	25	-	-	JJ
cord-270337-92a5uwjf	219	26	drug	drug	JJ
cord-270337-92a5uwjf	219	27	treatment	treatment	NN
cord-270337-92a5uwjf	219	28	/	/	SYM
cord-270337-92a5uwjf	219	29	vehicle	vehicle	NN
cord-270337-92a5uwjf	219	30	)	)	-RRB-
cord-270337-92a5uwjf	219	31	,	,	,
cord-270337-92a5uwjf	219	32	and	and	CC
cord-270337-92a5uwjf	219	33	30	30	CD
cord-270337-92a5uwjf	219	34	min	min	NN
cord-270337-92a5uwjf	219	35	post	post	NN
cord-270337-92a5uwjf	219	36	-	-	NNS
cord-270337-92a5uwjf	219	37	treatments	treatment	NNS
cord-270337-92a5uwjf	219	38	pre	pre	JJ
cord-270337-92a5uwjf	219	39	-	-	JJ
cord-270337-92a5uwjf	219	40	treatment	treatment	JJ
cord-270337-92a5uwjf	219	41	values	value	NNS
cord-270337-92a5uwjf	219	42	but	but	CC
cord-270337-92a5uwjf	219	43	not	not	RB
cord-270337-92a5uwjf	219	44	when	when	WRB
cord-270337-92a5uwjf	219	45	compared	compare	VBN
cord-270337-92a5uwjf	219	46	to	to	IN
cord-270337-92a5uwjf	219	47	the	the	DT
cord-270337-92a5uwjf	219	48	other	other	JJ
cord-270337-92a5uwjf	219	49	groups	group	NNS
cord-270337-92a5uwjf	219	50	.	.	.
cord-270337-92a5uwjf	220	1	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	220	2	did	do	VBD
cord-270337-92a5uwjf	220	3	not	not	RB
cord-270337-92a5uwjf	220	4	alter	alter	VB
cord-270337-92a5uwjf	220	5	electrolyte	electrolyte	JJ
cord-270337-92a5uwjf	220	6	concentrations	concentration	NNS
cord-270337-92a5uwjf	220	7	;	;	:
cord-270337-92a5uwjf	220	8	but	but	CC
cord-270337-92a5uwjf	220	9	pretreatment	pretreatment	NN
cord-270337-92a5uwjf	220	10	groups	group	NNS
cord-270337-92a5uwjf	220	11	containing	contain	VBG
cord-270337-92a5uwjf	220	12	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	220	13	were	be	VBD
cord-270337-92a5uwjf	220	14	more	more	RBR
cord-270337-92a5uwjf	220	15	hypokalaemic	hypokalaemic	JJ
cord-270337-92a5uwjf	220	16	than	than	IN
cord-270337-92a5uwjf	220	17	the	the	DT
cord-270337-92a5uwjf	220	18	diazepam	diazepam	NN
cord-270337-92a5uwjf	220	19	and	and	CC
cord-270337-92a5uwjf	220	20	control	control	NN
cord-270337-92a5uwjf	220	21	groups	group	NNS
cord-270337-92a5uwjf	220	22	(	(	-LRB-
cord-270337-92a5uwjf	220	23	Table	Table	NNP
cord-270337-92a5uwjf	220	24	4	4	CD
cord-270337-92a5uwjf	220	25	)	)	-RRB-
cord-270337-92a5uwjf	220	26	.	.	.
cord-270337-92a5uwjf	221	1	The	the	DT
cord-270337-92a5uwjf	221	2	results	result	NNS
cord-270337-92a5uwjf	221	3	of	of	IN
cord-270337-92a5uwjf	221	4	the	the	DT
cord-270337-92a5uwjf	221	5	study	study	NN
cord-270337-92a5uwjf	221	6	indicate	indicate	VBP
cord-270337-92a5uwjf	221	7	that	that	IN
cord-270337-92a5uwjf	221	8	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	221	9	prolongs	prolong	VBZ
cord-270337-92a5uwjf	221	10	the	the	DT
cord-270337-92a5uwjf	221	11	ERP	ERP	NNP
cord-270337-92a5uwjf	221	12	of	of	IN
cord-270337-92a5uwjf	221	13	isolated	isolate	VBN
cord-270337-92a5uwjf	221	14	rat	rat	NN
cord-270337-92a5uwjf	221	15	atria	atria	NN
cord-270337-92a5uwjf	221	16	.	.	.
cord-270337-92a5uwjf	222	1	In	in	IN
cord-270337-92a5uwjf	222	2	vivo	vivo	NN
cord-270337-92a5uwjf	222	3	experiments	experiment	NNS
cord-270337-92a5uwjf	222	4	also	also	RB
cord-270337-92a5uwjf	222	5	revealed	reveal	VBD
cord-270337-92a5uwjf	222	6	that	that	IN
cord-270337-92a5uwjf	222	7	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	222	8	induces	induce	VBZ
cord-270337-92a5uwjf	222	9	cardiac	cardiac	JJ
cord-270337-92a5uwjf	222	10	arrhythmias	arrhythmia	NNS
cord-270337-92a5uwjf	222	11	and	and	CC
cord-270337-92a5uwjf	222	12	pathophysiologic	pathophysiologic	JJ
cord-270337-92a5uwjf	222	13	changes	change	NNS
cord-270337-92a5uwjf	222	14	in	in	IN
cord-270337-92a5uwjf	222	15	haemodynamic	haemodynamic	NNP
cord-270337-92a5uwjf	222	16	and	and	CC
cord-270337-92a5uwjf	222	17	electrocardiographic	electrocardiographic	JJ
cord-270337-92a5uwjf	222	18	parameters	parameter	NNS
cord-270337-92a5uwjf	222	19	.	.	.
cord-270337-92a5uwjf	223	1	Different	different	JJ
cord-270337-92a5uwjf	223	2	protocols	protocol	NNS
cord-270337-92a5uwjf	223	3	of	of	IN
cord-270337-92a5uwjf	223	4	diazepam	diazepam	NNP
cord-270337-92a5uwjf	223	5	administration	administration	NN
cord-270337-92a5uwjf	223	6	did	do	VBD
cord-270337-92a5uwjf	223	7	not	not	RB
cord-270337-92a5uwjf	223	8	result	result	VB
cord-270337-92a5uwjf	223	9	in	in	IN
cord-270337-92a5uwjf	223	10	significant	significant	JJ
cord-270337-92a5uwjf	223	11	improvement	improvement	NN
cord-270337-92a5uwjf	223	12	in	in	IN
cord-270337-92a5uwjf	223	13	cardiac	cardiac	JJ
cord-270337-92a5uwjf	223	14	function	function	NN
cord-270337-92a5uwjf	223	15	either	either	CC
cord-270337-92a5uwjf	223	16	in	in	IN
cord-270337-92a5uwjf	223	17	vitro	vitro	FW
cord-270337-92a5uwjf	223	18	or	or	CC
cord-270337-92a5uwjf	223	19	in	in	IN
cord-270337-92a5uwjf	223	20	vivo	vivo	NNP
cord-270337-92a5uwjf	223	21	.	.	.
cord-270337-92a5uwjf	224	1	However	however	RB
cord-270337-92a5uwjf	224	2	,	,	,
cord-270337-92a5uwjf	224	3	the	the	DT
cord-270337-92a5uwjf	224	4	administration	administration	NN
cord-270337-92a5uwjf	224	5	of	of	IN
cord-270337-92a5uwjf	224	6	diazepam	diazepam	NNP
cord-270337-92a5uwjf	224	7	and	and	CC
cord-270337-92a5uwjf	224	8	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	224	9	in	in	IN
cord-270337-92a5uwjf	224	10	combination	combination	NN
cord-270337-92a5uwjf	224	11	may	may	MD
cord-270337-92a5uwjf	224	12	be	be	VB
cord-270337-92a5uwjf	224	13	effective	effective	JJ
cord-270337-92a5uwjf	224	14	against	against	IN
cord-270337-92a5uwjf	224	15	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	224	16	cardiotoxicity	cardiotoxicity	NN
cord-270337-92a5uwjf	224	17	by	by	IN
cord-270337-92a5uwjf	224	18	improving	improve	VBG
cord-270337-92a5uwjf	224	19	cardiac	cardiac	JJ
cord-270337-92a5uwjf	224	20	contractility	contractility	NN
cord-270337-92a5uwjf	224	21	.	.	.
cord-270337-92a5uwjf	225	1	The	the	DT
cord-270337-92a5uwjf	225	2	findings	finding	NNS
cord-270337-92a5uwjf	225	3	from	from	IN
cord-270337-92a5uwjf	225	4	the	the	DT
cord-270337-92a5uwjf	225	5	in	in	FW
cord-270337-92a5uwjf	225	6	vitro	vitro	FW
cord-270337-92a5uwjf	225	7	studies	study	NNS
cord-270337-92a5uwjf	225	8	are	be	VBP
cord-270337-92a5uwjf	225	9	congruent	congruent	JJ
cord-270337-92a5uwjf	225	10	with	with	IN
cord-270337-92a5uwjf	225	11	previous	previous	JJ
cord-270337-92a5uwjf	225	12	experiments	experiment	NNS
cord-270337-92a5uwjf	225	13	demonstrating	demonstrate	VBG
cord-270337-92a5uwjf	225	14	the	the	DT
cord-270337-92a5uwjf	225	15	acute	acute	JJ
cord-270337-92a5uwjf	225	16	cardiotoxic	cardiotoxic	JJ
cord-270337-92a5uwjf	225	17	effects	effect	NNS
cord-270337-92a5uwjf	225	18	of	of	IN
cord-270337-92a5uwjf	225	19	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	225	20	(	(	-LRB-
cord-270337-92a5uwjf	225	21	Essien	Essien	NNP
cord-270337-92a5uwjf	225	22	&	&	CC
cord-270337-92a5uwjf	225	23	Ette	Ette	NNP
cord-270337-92a5uwjf	225	24	,	,	,
cord-270337-92a5uwjf	225	25	1986	1986	CD
cord-270337-92a5uwjf	225	26	;	;	:
cord-270337-92a5uwjf	225	27	Tona	Tona	NNP
cord-270337-92a5uwjf	225	28	,	,	,
cord-270337-92a5uwjf	225	29	Ng	Ng	NNP
cord-270337-92a5uwjf	225	30	,	,	,
cord-270337-92a5uwjf	225	31	Akera	Akera	NNP
cord-270337-92a5uwjf	225	32	,	,	,
cord-270337-92a5uwjf	225	33	&	&	CC
cord-270337-92a5uwjf	225	34	Brody	Brody	NNP
cord-270337-92a5uwjf	225	35	,	,	,
cord-270337-92a5uwjf	225	36	1990	1990	CD
cord-270337-92a5uwjf	225	37	)	)	-RRB-
cord-270337-92a5uwjf	225	38	.	.	.
cord-270337-92a5uwjf	226	1	At	at	IN
cord-270337-92a5uwjf	226	2	the	the	DT
cord-270337-92a5uwjf	226	3	concentrations	concentration	NNS
cord-270337-92a5uwjf	226	4	of	of	IN
cord-270337-92a5uwjf	226	5	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	226	6	used	use	VBN
cord-270337-92a5uwjf	226	7	,	,	,
cord-270337-92a5uwjf	226	8	left	leave	VBN
cord-270337-92a5uwjf	226	9	atria	atria	NN
cord-270337-92a5uwjf	226	10	were	be	VBD
cord-270337-92a5uwjf	226	11	more	more	RBR
cord-270337-92a5uwjf	226	12	sensitive	sensitive	JJ
cord-270337-92a5uwjf	226	13	to	to	IN
cord-270337-92a5uwjf	226	14	detrimental	detrimental	JJ
cord-270337-92a5uwjf	226	15	effects	effect	NNS
cord-270337-92a5uwjf	226	16	on	on	IN
cord-270337-92a5uwjf	226	17	mechanical	mechanical	JJ
cord-270337-92a5uwjf	226	18	performance	performance	NN
cord-270337-92a5uwjf	226	19	than	than	IN
cord-270337-92a5uwjf	226	20	either	either	CC
cord-270337-92a5uwjf	226	21	ventricular	ventricular	JJ
cord-270337-92a5uwjf	226	22	or	or	CC
cord-270337-92a5uwjf	226	23	papillary	papillary	JJ
cord-270337-92a5uwjf	226	24	tissue	tissue	NN
cord-270337-92a5uwjf	226	25	preparations	preparation	NNS
cord-270337-92a5uwjf	226	26	.	.	.
cord-270337-92a5uwjf	227	1	Decreases	decrease	NNS
cord-270337-92a5uwjf	227	2	in	in	IN
cord-270337-92a5uwjf	227	3	developed	develop	VBN
cord-270337-92a5uwjf	227	4	isometric	isometric	JJ
cord-270337-92a5uwjf	227	5	tension	tension	NN
cord-270337-92a5uwjf	227	6	,	,	,
cord-270337-92a5uwjf	227	7	together	together	RB
cord-270337-92a5uwjf	227	8	with	with	IN
cord-270337-92a5uwjf	227	9	increases	increase	NNS
cord-270337-92a5uwjf	227	10	in	in	IN
cord-270337-92a5uwjf	227	11	times	time	NNS
cord-270337-92a5uwjf	227	12	to	to	TO
cord-270337-92a5uwjf	227	13	peak	peak	VB
cord-270337-92a5uwjf	227	14	tension	tension	NN
cord-270337-92a5uwjf	227	15	,	,	,
cord-270337-92a5uwjf	227	16	were	be	VBD
cord-270337-92a5uwjf	227	17	observed	observe	VBN
cord-270337-92a5uwjf	227	18	,	,	,
cord-270337-92a5uwjf	227	19	which	which	WDT
cord-270337-92a5uwjf	227	20	are	be	VBP
cord-270337-92a5uwjf	227	21	indicative	indicative	JJ
cord-270337-92a5uwjf	227	22	of	of	IN
cord-270337-92a5uwjf	227	23	impaired	impaired	JJ
cord-270337-92a5uwjf	227	24	atrial	atrial	JJ
cord-270337-92a5uwjf	227	25	contractility	contractility	NN
cord-270337-92a5uwjf	227	26	.	.	.
cord-270337-92a5uwjf	228	1	An	an	DT
cord-270337-92a5uwjf	228	2	increase	increase	NN
cord-270337-92a5uwjf	228	3	in	in	IN
cord-270337-92a5uwjf	228	4	the	the	DT
cord-270337-92a5uwjf	228	5	time	time	NN
cord-270337-92a5uwjf	228	6	to	to	TO
cord-270337-92a5uwjf	228	7	peak	peak	VB
cord-270337-92a5uwjf	228	8	tension	tension	NN
cord-270337-92a5uwjf	228	9	by	by	IN
cord-270337-92a5uwjf	228	10	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	228	11	reflects	reflect	VBZ
cord-270337-92a5uwjf	228	12	a	a	DT
cord-270337-92a5uwjf	228	13	prolongation	prolongation	NN
cord-270337-92a5uwjf	228	14	of	of	IN
cord-270337-92a5uwjf	228	15	one	one	CD
cord-270337-92a5uwjf	228	16	or	or	CC
cord-270337-92a5uwjf	228	17	more	more	JJR
cord-270337-92a5uwjf	228	18	phases	phase	NNS
cord-270337-92a5uwjf	228	19	of	of	IN
cord-270337-92a5uwjf	228	20	the	the	DT
cord-270337-92a5uwjf	228	21	cardiac	cardiac	JJ
cord-270337-92a5uwjf	228	22	excitation	excitation	NN
cord-270337-92a5uwjf	228	23	-	-	HYPH
cord-270337-92a5uwjf	228	24	contraction	contraction	NN
cord-270337-92a5uwjf	228	25	cycle	cycle	NN
cord-270337-92a5uwjf	228	26	and	and	CC
cord-270337-92a5uwjf	228	27	is	be	VBZ
cord-270337-92a5uwjf	228	28	consistent	consistent	JJ
cord-270337-92a5uwjf	228	29	with	with	IN
cord-270337-92a5uwjf	228	30	the	the	DT
cord-270337-92a5uwjf	228	31	ability	ability	NN
cord-270337-92a5uwjf	228	32	of	of	IN
cord-270337-92a5uwjf	228	33	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	228	34	to	to	TO
cord-270337-92a5uwjf	228	35	block	block	VB
cord-270337-92a5uwjf	228	36	cardiac	cardiac	JJ
cord-270337-92a5uwjf	228	37	ion	ion	NN
cord-270337-92a5uwjf	228	38	channels	channel	NNS
cord-270337-92a5uwjf	228	39	(	(	-LRB-
cord-270337-92a5uwjf	228	40	Essien	Essien	NNP
cord-270337-92a5uwjf	228	41	&	&	CC
cord-270337-92a5uwjf	228	42	Ette	Ette	NNP
cord-270337-92a5uwjf	228	43	,	,	,
cord-270337-92a5uwjf	228	44	1986	1986	CD
cord-270337-92a5uwjf	228	45	;	;	:
cord-270337-92a5uwjf	228	46	Rodríguez	Rodríguez	NNP
cord-270337-92a5uwjf	228	47	-	-	HYPH
cord-270337-92a5uwjf	228	48	Menchaca	Menchaca	NNP
cord-270337-92a5uwjf	228	49	et	et	NNP
cord-270337-92a5uwjf	228	50	al	al	NNP
cord-270337-92a5uwjf	228	51	.	.	NNP
cord-270337-92a5uwjf	228	52	,	,	,
cord-270337-92a5uwjf	228	53	2008	2008	CD
cord-270337-92a5uwjf	228	54	;	;	:
cord-270337-92a5uwjf	228	55	Sánchez	Sánchez	NNP
cord-270337-92a5uwjf	228	56	-	-	HYPH
cord-270337-92a5uwjf	228	57	Chapula	Chapula	NNP
cord-270337-92a5uwjf	228	58	,	,	,
cord-270337-92a5uwjf	228	59	Salinas	Salinas	NNP
cord-270337-92a5uwjf	228	60	-	-	HYPH
cord-270337-92a5uwjf	228	61	Stefanon	Stefanon	NNP
cord-270337-92a5uwjf	228	62	,	,	,
cord-270337-92a5uwjf	228	63	Torres	Torres	NNP
cord-270337-92a5uwjf	228	64	-	-	HYPH
cord-270337-92a5uwjf	228	65	Jácome	Jácome	NNP
cord-270337-92a5uwjf	228	66	,	,	,
cord-270337-92a5uwjf	228	67	Benavides	Benavides	NNP
cord-270337-92a5uwjf	228	68	-	-	HYPH
cord-270337-92a5uwjf	228	69	Haro	Haro	NNP
cord-270337-92a5uwjf	228	70	,	,	,
cord-270337-92a5uwjf	228	71	&	&	CC
cord-270337-92a5uwjf	228	72	Navarro	Navarro	NNP
cord-270337-92a5uwjf	228	73	-	-	HYPH
cord-270337-92a5uwjf	228	74	Polanco	Polanco	NNP
cord-270337-92a5uwjf	228	75	,	,	,
cord-270337-92a5uwjf	228	76	2001	2001	CD
cord-270337-92a5uwjf	228	77	;	;	:
cord-270337-92a5uwjf	228	78	Tona	Tona	NNP
cord-270337-92a5uwjf	228	79	et	et	NNP
cord-270337-92a5uwjf	228	80	al	al	NNP
cord-270337-92a5uwjf	228	81	.	.	NNP
cord-270337-92a5uwjf	228	82	,	,	,
cord-270337-92a5uwjf	228	83	1990	1990	CD
cord-270337-92a5uwjf	228	84	)	)	-RRB-
cord-270337-92a5uwjf	228	85	.	.	.
cord-270337-92a5uwjf	229	1	Ikhinmwin	Ikhinmwin	NNP
cord-270337-92a5uwjf	229	2	,	,	,
cord-270337-92a5uwjf	229	3	Sofola	Sofola	NNP
cord-270337-92a5uwjf	229	4	,	,	,
cord-270337-92a5uwjf	229	5	and	and	CC
cord-270337-92a5uwjf	229	6	Elebute	Elebute	NNP
cord-270337-92a5uwjf	229	7	(	(	-LRB-
cord-270337-92a5uwjf	229	8	1981	1981	CD
cord-270337-92a5uwjf	229	9	)	)	-RRB-
cord-270337-92a5uwjf	229	10	demonstrated	demonstrate	VBD
cord-270337-92a5uwjf	229	11	a	a	DT
cord-270337-92a5uwjf	229	12	negative	negative	JJ
cord-270337-92a5uwjf	229	13	inotropic	inotropic	NNP
cord-270337-92a5uwjf	229	14	response	response	NN
cord-270337-92a5uwjf	229	15	which	which	WDT
cord-270337-92a5uwjf	229	16	was	be	VBD
cord-270337-92a5uwjf	229	17	reversed	reverse	VBN
cord-270337-92a5uwjf	229	18	in	in	IN
cord-270337-92a5uwjf	229	19	the	the	DT
cord-270337-92a5uwjf	229	20	presence	presence	NN
cord-270337-92a5uwjf	229	21	of	of	IN
cord-270337-92a5uwjf	229	22	increased	increase	VBN
cord-270337-92a5uwjf	229	23	extracellular	extracellular	JJ
cord-270337-92a5uwjf	229	24	calcium	calcium	NN
cord-270337-92a5uwjf	229	25	aimed	aim	VBN
cord-270337-92a5uwjf	229	26	to	to	TO
cord-270337-92a5uwjf	229	27	promote	promote	VB
cord-270337-92a5uwjf	229	28	calcium	calcium	NN
cord-270337-92a5uwjf	229	29	influx	influx	NN
cord-270337-92a5uwjf	229	30	via	via	IN
cord-270337-92a5uwjf	229	31	unblocked	unblocked	JJ
cord-270337-92a5uwjf	229	32	L	l	NN
cord-270337-92a5uwjf	229	33	-	-	HYPH
cord-270337-92a5uwjf	229	34	type	type	NN
cord-270337-92a5uwjf	229	35	calcium	calcium	NN
cord-270337-92a5uwjf	229	36	channels	channel	NNS
cord-270337-92a5uwjf	229	37	.	.	.
cord-270337-92a5uwjf	230	1	Tona	Tona	NNP
cord-270337-92a5uwjf	230	2	et	et	NNP
cord-270337-92a5uwjf	230	3	al	al	NNP
cord-270337-92a5uwjf	230	4	.	.	.
cord-270337-92a5uwjf	231	1	(	(	-LRB-
cord-270337-92a5uwjf	231	2	1990	1990	CD
cord-270337-92a5uwjf	231	3	)	)	-RRB-
cord-270337-92a5uwjf	231	4	demonstrated	demonstrate	VBD
cord-270337-92a5uwjf	231	5	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	231	6	to	to	TO
cord-270337-92a5uwjf	231	7	inhibit	inhibit	VB
cord-270337-92a5uwjf	231	8	the	the	DT
cord-270337-92a5uwjf	231	9	Treppe	Treppe	NNP
cord-270337-92a5uwjf	231	10	response	response	NN
cord-270337-92a5uwjf	231	11	in	in	IN
cord-270337-92a5uwjf	231	12	atrial	atrial	JJ
cord-270337-92a5uwjf	231	13	guinea	guinea	NN
cord-270337-92a5uwjf	231	14	pig	pig	NN
cord-270337-92a5uwjf	231	15	preparations	preparation	NNS
cord-270337-92a5uwjf	231	16	,	,	,
cord-270337-92a5uwjf	231	17	but	but	CC
cord-270337-92a5uwjf	231	18	without	without	IN
cord-270337-92a5uwjf	231	19	effect	effect	NN
cord-270337-92a5uwjf	231	20	on	on	IN
cord-270337-92a5uwjf	231	21	postextrasystolic	postextrasystolic	JJ
cord-270337-92a5uwjf	231	22	potentiation	potentiation	NN
cord-270337-92a5uwjf	231	23	of	of	IN
cord-270337-92a5uwjf	231	24	contractile	contractile	JJ
cord-270337-92a5uwjf	231	25	force	force	NN
cord-270337-92a5uwjf	231	26	,	,	,
cord-270337-92a5uwjf	231	27	suggesting	suggest	VBG
cord-270337-92a5uwjf	231	28	that	that	IN
cord-270337-92a5uwjf	231	29	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	231	30	interferes	interfere	VBZ
cord-270337-92a5uwjf	231	31	with	with	IN
cord-270337-92a5uwjf	231	32	cellular	cellular	JJ
cord-270337-92a5uwjf	231	33	calcium	calcium	NN
cord-270337-92a5uwjf	231	34	influx	influx	NN
cord-270337-92a5uwjf	231	35	upon	upon	IN
cord-270337-92a5uwjf	231	36	which	which	WDT
cord-270337-92a5uwjf	231	37	the	the	DT
cord-270337-92a5uwjf	231	38	Treppe	Treppe	NNP
cord-270337-92a5uwjf	231	39	response	response	NN
cord-270337-92a5uwjf	231	40	is	be	VBZ
cord-270337-92a5uwjf	231	41	dependent	dependent	JJ
cord-270337-92a5uwjf	231	42	,	,	,
cord-270337-92a5uwjf	231	43	but	but	CC
cord-270337-92a5uwjf	231	44	not	not	RB
cord-270337-92a5uwjf	231	45	the	the	DT
cord-270337-92a5uwjf	231	46	latter	latter	JJ
cord-270337-92a5uwjf	231	47	response	response	NN
cord-270337-92a5uwjf	231	48	which	which	WDT
cord-270337-92a5uwjf	231	49	is	be	VBZ
cord-270337-92a5uwjf	231	50	dependent	dependent	JJ
cord-270337-92a5uwjf	231	51	on	on	IN
cord-270337-92a5uwjf	231	52	intracellular	intracellular	JJ
cord-270337-92a5uwjf	231	53	calcium	calcium	NN
cord-270337-92a5uwjf	231	54	mobilisation	mobilisation	NN
cord-270337-92a5uwjf	231	55	.	.	.
cord-270337-92a5uwjf	232	1	Increases	increase	NNS
cord-270337-92a5uwjf	232	2	in	in	IN
cord-270337-92a5uwjf	232	3	the	the	DT
cord-270337-92a5uwjf	232	4	refractoriness	refractoriness	NN
cord-270337-92a5uwjf	232	5	of	of	IN
cord-270337-92a5uwjf	232	6	cardiac	cardiac	JJ
cord-270337-92a5uwjf	232	7	tissues	tissue	NNS
cord-270337-92a5uwjf	232	8	are	be	VBP
cord-270337-92a5uwjf	232	9	indicative	indicative	JJ
cord-270337-92a5uwjf	232	10	of	of	IN
cord-270337-92a5uwjf	232	11	potassium	potassium	NN
cord-270337-92a5uwjf	232	12	and/or	and/or	CC
cord-270337-92a5uwjf	232	13	sodium	sodium	NN
cord-270337-92a5uwjf	232	14	ion	ion	NN
cord-270337-92a5uwjf	232	15	channel	channel	NN
cord-270337-92a5uwjf	232	16	blockade	blockade	NN
cord-270337-92a5uwjf	232	17	.	.	.
cord-270337-92a5uwjf	233	1	Using	use	VBG
cord-270337-92a5uwjf	233	2	voltage	voltage	NN
cord-270337-92a5uwjf	233	3	-	-	HYPH
cord-270337-92a5uwjf	233	4	clamped	clamp	VBN
cord-270337-92a5uwjf	233	5	cat	cat	NN
cord-270337-92a5uwjf	233	6	ventricular	ventricular	JJ
cord-270337-92a5uwjf	233	7	myocytes	myocyte	NNS
cord-270337-92a5uwjf	233	8	,	,	,
cord-270337-92a5uwjf	233	9	Sánchez	Sánchez	NNP
cord-270337-92a5uwjf	233	10	-	-	HYPH
cord-270337-92a5uwjf	233	11	Chapula	Chapula	NNP
cord-270337-92a5uwjf	233	12	et	et	NNP
cord-270337-92a5uwjf	233	13	al	al	NNP
cord-270337-92a5uwjf	233	14	.	.	.
cord-270337-92a5uwjf	234	1	(	(	-LRB-
cord-270337-92a5uwjf	234	2	2001	2001	CD
cord-270337-92a5uwjf	234	3	)	)	-RRB-
cord-270337-92a5uwjf	234	4	observed	observe	VBD
cord-270337-92a5uwjf	234	5	that	that	IN
cord-270337-92a5uwjf	234	6	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	234	7	blocked	block	VBD
cord-270337-92a5uwjf	234	8	several	several	JJ
cord-270337-92a5uwjf	234	9	inward	inward	RB
cord-270337-92a5uwjf	234	10	and	and	CC
cord-270337-92a5uwjf	234	11	outward	outward	JJ
cord-270337-92a5uwjf	234	12	membrane	membrane	NN
cord-270337-92a5uwjf	234	13	currents	current	NNS
cord-270337-92a5uwjf	234	14	.	.	.
cord-270337-92a5uwjf	235	1	The	the	DT
cord-270337-92a5uwjf	235	2	order	order	NN
cord-270337-92a5uwjf	235	3	of	of	IN
cord-270337-92a5uwjf	235	4	potency	potency	NN
cord-270337-92a5uwjf	235	5	(	(	-LRB-
cord-270337-92a5uwjf	235	6	1	1	CD
cord-270337-92a5uwjf	235	7	-	-	SYM
cord-270337-92a5uwjf	235	8	10	10	CD
cord-270337-92a5uwjf	235	9	μM	μm	CD
cord-270337-92a5uwjf	235	10	range	range	NN
cord-270337-92a5uwjf	235	11	)	)	-RRB-
cord-270337-92a5uwjf	235	12	was	be	VBD
cord-270337-92a5uwjf	235	13	inward	inward	RB
cord-270337-92a5uwjf	235	14	rectifying	rectify	VBG
cord-270337-92a5uwjf	235	15	potassium	potassium	NN
cord-270337-92a5uwjf	235	16	current	current	NN
cord-270337-92a5uwjf	235	17	>	>	XX
cord-270337-92a5uwjf	235	18	rapid	rapid	JJ
cord-270337-92a5uwjf	235	19	delayed	delay	VBN
cord-270337-92a5uwjf	235	20	rectifying	rectify	VBG
cord-270337-92a5uwjf	236	1	potassium	potassium	NN
cord-270337-92a5uwjf	236	2	current	current	NN
cord-270337-92a5uwjf	236	3	>	>	XX
cord-270337-92a5uwjf	237	1	sodium	sodium	NN
cord-270337-92a5uwjf	237	2	current	current	JJ
cord-270337-92a5uwjf	238	1	>	>	XX
cord-270337-92a5uwjf	238	2	L	l	NN
cord-270337-92a5uwjf	238	3	-	-	HYPH
cord-270337-92a5uwjf	238	4	type	type	NN
cord-270337-92a5uwjf	238	5	calcium	calcium	NN
cord-270337-92a5uwjf	238	6	current	current	JJ
cord-270337-92a5uwjf	238	7	.	.	.
cord-270337-92a5uwjf	239	1	Neither	neither	CC
cord-270337-92a5uwjf	239	2	the	the	DT
cord-270337-92a5uwjf	239	3	transient	transient	JJ
cord-270337-92a5uwjf	239	4	outward	outward	JJ
cord-270337-92a5uwjf	239	5	potassium	potassium	NN
cord-270337-92a5uwjf	239	6	current	current	NN
cord-270337-92a5uwjf	239	7	nor	nor	CC
cord-270337-92a5uwjf	239	8	the	the	DT
cord-270337-92a5uwjf	239	9	slow	slow	JJ
cord-270337-92a5uwjf	239	10	delayed	delay	VBN
cord-270337-92a5uwjf	239	11	rectifying	rectify	VBG
cord-270337-92a5uwjf	239	12	potassium	potassium	NN
cord-270337-92a5uwjf	239	13	current	current	NN
cord-270337-92a5uwjf	239	14	was	be	VBD
cord-270337-92a5uwjf	239	15	modified	modify	VBN
cord-270337-92a5uwjf	239	16	by	by	IN
cord-270337-92a5uwjf	239	17	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	239	18	.	.	.
cord-270337-92a5uwjf	240	1	Salinas	Salinas	NNP
cord-270337-92a5uwjf	240	2	and	and	CC
cord-270337-92a5uwjf	240	3	Cebada	Cebada	NNP
cord-270337-92a5uwjf	240	4	(	(	-LRB-
cord-270337-92a5uwjf	240	5	1993	1993	CD
cord-270337-92a5uwjf	240	6	)	)	-RRB-
cord-270337-92a5uwjf	240	7	also	also	RB
cord-270337-92a5uwjf	240	8	demonstrated	demonstrate	VBD
cord-270337-92a5uwjf	240	9	that	that	IN
cord-270337-92a5uwjf	240	10	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	240	11	blocks	block	VBZ
cord-270337-92a5uwjf	240	12	the	the	DT
cord-270337-92a5uwjf	240	13	inward	inward	JJ
cord-270337-92a5uwjf	240	14	rectifying	rectify	VBG
cord-270337-92a5uwjf	240	15	potassium	potassium	NN
cord-270337-92a5uwjf	240	16	current	current	NN
cord-270337-92a5uwjf	240	17	in	in	IN
cord-270337-92a5uwjf	240	18	dog	dog	NN
cord-270337-92a5uwjf	240	19	cardiac	cardiac	NN
cord-270337-92a5uwjf	240	20	myocytes	myocyte	NNS
cord-270337-92a5uwjf	240	21	but	but	CC
cord-270337-92a5uwjf	240	22	had	have	VBD
cord-270337-92a5uwjf	240	23	no	no	DT
cord-270337-92a5uwjf	240	24	effects	effect	NNS
cord-270337-92a5uwjf	240	25	on	on	IN
cord-270337-92a5uwjf	240	26	either	either	CC
cord-270337-92a5uwjf	240	27	the	the	DT
cord-270337-92a5uwjf	240	28	transient	transient	JJ
cord-270337-92a5uwjf	240	29	outward	outward	RB
cord-270337-92a5uwjf	240	30	or	or	CC
cord-270337-92a5uwjf	240	31	the	the	DT
cord-270337-92a5uwjf	240	32	delayed	delay	VBN
cord-270337-92a5uwjf	240	33	rectifier	rectifier	NN
cord-270337-92a5uwjf	240	34	currents	current	NNS
cord-270337-92a5uwjf	240	35	.	.	.
cord-270337-92a5uwjf	241	1	Rodríguez	Rodríguez	NNP
cord-270337-92a5uwjf	241	2	-	-	HYPH
cord-270337-92a5uwjf	241	3	Menchaca	Menchaca	NNP
cord-270337-92a5uwjf	241	4	et	et	NNP
cord-270337-92a5uwjf	241	5	al	al	NNP
cord-270337-92a5uwjf	241	6	.	.	.
cord-270337-92a5uwjf	242	1	(	(	-LRB-
cord-270337-92a5uwjf	242	2	2008	2008	CD
cord-270337-92a5uwjf	242	3	)	)	-RRB-
cord-270337-92a5uwjf	242	4	established	establish	VBD
cord-270337-92a5uwjf	242	5	that	that	IN
cord-270337-92a5uwjf	242	6	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	242	7	blocks	block	VBZ
cord-270337-92a5uwjf	242	8	the	the	DT
cord-270337-92a5uwjf	242	9	inward	inward	JJ
cord-270337-92a5uwjf	242	10	rectifier	rectifier	NN
cord-270337-92a5uwjf	242	11	K	K	NNP
cord-270337-92a5uwjf	242	12	ir	ir	NNP
cord-270337-92a5uwjf	242	13	2.1	2.1	CD
cord-270337-92a5uwjf	242	14	channels	channel	NNS
cord-270337-92a5uwjf	242	15	,	,	,
cord-270337-92a5uwjf	242	16	that	that	WDT
cord-270337-92a5uwjf	242	17	underlie	underlie	VBP
cord-270337-92a5uwjf	242	18	the	the	DT
cord-270337-92a5uwjf	242	19	cardiac	cardiac	JJ
cord-270337-92a5uwjf	242	20	inward	inward	JJ
cord-270337-92a5uwjf	242	21	rectifier	rectifier	NN
cord-270337-92a5uwjf	242	22	potassium	potassium	NN
cord-270337-92a5uwjf	242	23	current	current	NN
cord-270337-92a5uwjf	242	24	,	,	,
cord-270337-92a5uwjf	242	25	from	from	IN
cord-270337-92a5uwjf	242	26	the	the	DT
cord-270337-92a5uwjf	242	27	cytoplasmic	cytoplasmic	JJ
cord-270337-92a5uwjf	242	28	surface	surface	NN
cord-270337-92a5uwjf	242	29	.	.	.
cord-270337-92a5uwjf	243	1	Other	other	JJ
cord-270337-92a5uwjf	243	2	quinolone	quinolone	NNP
cord-270337-92a5uwjf	243	3	antimalarials	antimalarial	NNS
cord-270337-92a5uwjf	243	4	also	also	RB
cord-270337-92a5uwjf	243	5	have	have	VBP
cord-270337-92a5uwjf	243	6	known	know	VBN
cord-270337-92a5uwjf	243	7	actions	action	NNS
cord-270337-92a5uwjf	243	8	in	in	IN
cord-270337-92a5uwjf	243	9	modulating	modulate	VBG
cord-270337-92a5uwjf	243	10	cardiac	cardiac	JJ
cord-270337-92a5uwjf	243	11	electrical	electrical	JJ
cord-270337-92a5uwjf	243	12	activity	activity	NN
cord-270337-92a5uwjf	243	13	,	,	,
cord-270337-92a5uwjf	243	14	including	include	VBG
cord-270337-92a5uwjf	243	15	blockade	blockade	NN
cord-270337-92a5uwjf	243	16	of	of	IN
cord-270337-92a5uwjf	243	17	human	human	JJ
cord-270337-92a5uwjf	243	18	ether	ether	NN
cord-270337-92a5uwjf	243	19	-	-	HYPH
cord-270337-92a5uwjf	243	20	ago	ago	RB
cord-270337-92a5uwjf	243	21	-	-	HYPH
cord-270337-92a5uwjf	243	22	go	go	NN
cord-270337-92a5uwjf	243	23	related	related	JJ
cord-270337-92a5uwjf	243	24	gene	gene	NN
cord-270337-92a5uwjf	243	25	(	(	-LRB-
cord-270337-92a5uwjf	243	26	hERG	herg	NN
cord-270337-92a5uwjf	243	27	)	)	-RRB-
cord-270337-92a5uwjf	243	28	potassium	potassium	NN
cord-270337-92a5uwjf	243	29	and	and	CC
cord-270337-92a5uwjf	243	30	L	l	NN
cord-270337-92a5uwjf	243	31	-	-	HYPH
cord-270337-92a5uwjf	243	32	type	type	NN
cord-270337-92a5uwjf	243	33	calcium	calcium	NN
cord-270337-92a5uwjf	243	34	channels	channel	NNS
cord-270337-92a5uwjf	243	35	(	(	-LRB-
cord-270337-92a5uwjf	243	36	Coker	Coker	NNP
cord-270337-92a5uwjf	243	37	,	,	,
cord-270337-92a5uwjf	243	38	Batey	Batey	NNP
cord-270337-92a5uwjf	243	39	,	,	,
cord-270337-92a5uwjf	243	40	Lightbown	Lightbown	NNP
cord-270337-92a5uwjf	243	41	,	,	,
cord-270337-92a5uwjf	243	42	Díaz	Díaz	NNP
cord-270337-92a5uwjf	243	43	,	,	,
cord-270337-92a5uwjf	243	44	&	&	CC
cord-270337-92a5uwjf	243	45	Eisner	Eisner	NNP
cord-270337-92a5uwjf	243	46	,	,	,
cord-270337-92a5uwjf	243	47	2000	2000	CD
cord-270337-92a5uwjf	243	48	;	;	:
cord-270337-92a5uwjf	243	49	Kim	Kim	NNP
cord-270337-92a5uwjf	243	50	,	,	,
cord-270337-92a5uwjf	243	51	Lee	Lee	NNP
cord-270337-92a5uwjf	243	52	,	,	,
cord-270337-92a5uwjf	243	53	Cha	Cha	NNP
cord-270337-92a5uwjf	243	54	,	,	,
cord-270337-92a5uwjf	243	55	Kwon	Kwon	NNP
cord-270337-92a5uwjf	243	56	,	,	,
cord-270337-92a5uwjf	243	57	&	&	CC
cord-270337-92a5uwjf	243	58	Kim	Kim	NNP
cord-270337-92a5uwjf	243	59	,	,	,
cord-270337-92a5uwjf	243	60	2010	2010	CD
cord-270337-92a5uwjf	243	61	;	;	:
cord-270337-92a5uwjf	243	62	Michel	Michel	NNP
cord-270337-92a5uwjf	243	63	,	,	,
cord-270337-92a5uwjf	243	64	Wegener	Wegener	NNP
cord-270337-92a5uwjf	243	65	,	,	,
cord-270337-92a5uwjf	243	66	&	&	CC
cord-270337-92a5uwjf	243	67	Nawrath	Nawrath	NNP
cord-270337-92a5uwjf	243	68	,	,	,
cord-270337-92a5uwjf	243	69	2002	2002	CD
cord-270337-92a5uwjf	243	70	)	)	-RRB-
cord-270337-92a5uwjf	243	71	.	.	.
cord-270337-92a5uwjf	244	1	Diazepam	diazepam	NN
cord-270337-92a5uwjf	244	2	had	have	VBD
cord-270337-92a5uwjf	244	3	little	little	JJ
cord-270337-92a5uwjf	244	4	effect	effect	NN
cord-270337-92a5uwjf	244	5	on	on	IN
cord-270337-92a5uwjf	244	6	the	the	DT
cord-270337-92a5uwjf	244	7	function	function	NN
cord-270337-92a5uwjf	244	8	of	of	IN
cord-270337-92a5uwjf	244	9	myocardial	myocardial	JJ
cord-270337-92a5uwjf	244	10	tissue	tissue	NN
cord-270337-92a5uwjf	244	11	,	,	,
cord-270337-92a5uwjf	244	12	other	other	JJ
cord-270337-92a5uwjf	244	13	than	than	IN
cord-270337-92a5uwjf	244	14	at	at	IN
cord-270337-92a5uwjf	244	15	100	100	CD
cord-270337-92a5uwjf	244	16	μM	μM	NNP
cord-270337-92a5uwjf	244	17	,	,	,
cord-270337-92a5uwjf	244	18	where	where	WRB
cord-270337-92a5uwjf	244	19	it	-PRON-	PRP
cord-270337-92a5uwjf	244	20	increased	increase	VBD
cord-270337-92a5uwjf	244	21	the	the	DT
cord-270337-92a5uwjf	244	22	ERP	ERP	NNP
cord-270337-92a5uwjf	244	23	and	and	CC
cord-270337-92a5uwjf	244	24	peak	peak	NN
cord-270337-92a5uwjf	244	25	developed	develop	VBN
cord-270337-92a5uwjf	244	26	tension	tension	NN
cord-270337-92a5uwjf	244	27	in	in	IN
cord-270337-92a5uwjf	244	28	left	left	JJ
cord-270337-92a5uwjf	244	29	atrial	atrial	JJ
cord-270337-92a5uwjf	244	30	preparations	preparation	NNS
cord-270337-92a5uwjf	244	31	and	and	CC
cord-270337-92a5uwjf	244	32	increased	increase	VBD
cord-270337-92a5uwjf	244	33	the	the	DT
cord-270337-92a5uwjf	244	34	times	time	NNS
cord-270337-92a5uwjf	244	35	to	to	TO
cord-270337-92a5uwjf	244	36	peak	peak	VB
cord-270337-92a5uwjf	244	37	tension	tension	NN
cord-270337-92a5uwjf	244	38	in	in	IN
cord-270337-92a5uwjf	244	39	right	right	JJ
cord-270337-92a5uwjf	244	40	ventricular	ventricular	JJ
cord-270337-92a5uwjf	244	41	strips	strip	NNS
cord-270337-92a5uwjf	244	42	.	.	.
cord-270337-92a5uwjf	245	1	Diazepam	Diazepam	NNP
cord-270337-92a5uwjf	245	2	inhibits	inhibit	VBZ
cord-270337-92a5uwjf	245	3	PDE4	PDE4	NNP
cord-270337-92a5uwjf	246	1	(	(	-LRB-
cord-270337-92a5uwjf	246	2	Collado	Collado	NNP
cord-270337-92a5uwjf	246	3	et	et	FW
cord-270337-92a5uwjf	246	4	al	al	NNP
cord-270337-92a5uwjf	246	5	.	.	NNP
cord-270337-92a5uwjf	246	6	,	,	,
cord-270337-92a5uwjf	246	7	1998	1998	CD
cord-270337-92a5uwjf	246	8	)	)	-RRB-
cord-270337-92a5uwjf	246	9	,	,	,
cord-270337-92a5uwjf	246	10	suggesting	suggest	VBG
cord-270337-92a5uwjf	246	11	a	a	DT
cord-270337-92a5uwjf	246	12	possible	possible	JJ
cord-270337-92a5uwjf	246	13	mechanism	mechanism	NN
cord-270337-92a5uwjf	246	14	for	for	IN
cord-270337-92a5uwjf	246	15	cardioprotection	cardioprotection	NN
cord-270337-92a5uwjf	246	16	,	,	,
cord-270337-92a5uwjf	246	17	although	although	IN
cord-270337-92a5uwjf	246	18	this	this	DT
cord-270337-92a5uwjf	246	19	occurs	occur	VBZ
cord-270337-92a5uwjf	246	20	at	at	IN
cord-270337-92a5uwjf	246	21	lower	low	JJR
cord-270337-92a5uwjf	246	22	concentrations	concentration	NNS
cord-270337-92a5uwjf	246	23	(	(	-LRB-
cord-270337-92a5uwjf	246	24	IC	IC	NNP
cord-270337-92a5uwjf	246	25	50	50	CD
cord-270337-92a5uwjf	246	26	of	of	IN
cord-270337-92a5uwjf	246	27	8.7	8.7	CD
cord-270337-92a5uwjf	246	28	μM	μm	CD
cord-270337-92a5uwjf	246	29	)	)	-RRB-
cord-270337-92a5uwjf	246	30	than	than	IN
cord-270337-92a5uwjf	246	31	required	require	VBN
cord-270337-92a5uwjf	246	32	to	to	TO
cord-270337-92a5uwjf	246	33	elicit	elicit	VB
cord-270337-92a5uwjf	246	34	responses	response	NNS
cord-270337-92a5uwjf	246	35	in	in	IN
cord-270337-92a5uwjf	246	36	the	the	DT
cord-270337-92a5uwjf	246	37	present	present	JJ
cord-270337-92a5uwjf	246	38	investigation	investigation	NN
cord-270337-92a5uwjf	246	39	.	.	.
cord-270337-92a5uwjf	247	1	The	the	DT
cord-270337-92a5uwjf	247	2	responses	response	NNS
cord-270337-92a5uwjf	247	3	of	of	IN
cord-270337-92a5uwjf	247	4	cardiac	cardiac	JJ
cord-270337-92a5uwjf	247	5	tissues	tissue	NNS
cord-270337-92a5uwjf	247	6	to	to	IN
cord-270337-92a5uwjf	247	7	chloroquine	chloroquine	VB
cord-270337-92a5uwjf	247	8	in	in	IN
cord-270337-92a5uwjf	247	9	the	the	DT
cord-270337-92a5uwjf	247	10	presence	presence	NN
cord-270337-92a5uwjf	247	11	of	of	IN
cord-270337-92a5uwjf	247	12	diazepam	diazepam	NNP
cord-270337-92a5uwjf	247	13	were	be	VBD
cord-270337-92a5uwjf	247	14	no	no	RB
cord-270337-92a5uwjf	247	15	different	different	JJ
cord-270337-92a5uwjf	247	16	from	from	IN
cord-270337-92a5uwjf	247	17	vehicle	vehicle	NN
cord-270337-92a5uwjf	247	18	controls	control	NNS
cord-270337-92a5uwjf	247	19	,	,	,
cord-270337-92a5uwjf	247	20	supporting	support	VBG
cord-270337-92a5uwjf	247	21	previous	previous	JJ
cord-270337-92a5uwjf	247	22	observations	observation	NNS
cord-270337-92a5uwjf	247	23	that	that	WDT
cord-270337-92a5uwjf	247	24	diazepam	diazepam	NN
cord-270337-92a5uwjf	247	25	does	do	VBZ
cord-270337-92a5uwjf	247	26	not	not	RB
cord-270337-92a5uwjf	247	27	attenuate	attenuate	VB
cord-270337-92a5uwjf	247	28	the	the	DT
cord-270337-92a5uwjf	247	29	cardiac	cardiac	JJ
cord-270337-92a5uwjf	247	30	effects	effect	NNS
cord-270337-92a5uwjf	247	31	of	of	IN
cord-270337-92a5uwjf	247	32	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	247	33	via	via	IN
cord-270337-92a5uwjf	247	34	a	a	DT
cord-270337-92a5uwjf	247	35	direct	direct	JJ
cord-270337-92a5uwjf	247	36	action	action	NN
cord-270337-92a5uwjf	247	37	upon	upon	IN
cord-270337-92a5uwjf	247	38	the	the	DT
cord-270337-92a5uwjf	247	39	heart	heart	NN
cord-270337-92a5uwjf	248	1	(	(	-LRB-
cord-270337-92a5uwjf	248	2	Riou	Riou	NNP
cord-270337-92a5uwjf	248	3	et	et	NNP
cord-270337-92a5uwjf	248	4	al	al	NNP
cord-270337-92a5uwjf	248	5	.	.	NNP
cord-270337-92a5uwjf	248	6	,	,	,
cord-270337-92a5uwjf	248	7	1989	1989	CD
cord-270337-92a5uwjf	248	8	)	)	-RRB-
cord-270337-92a5uwjf	248	9	.	.	.
cord-270337-92a5uwjf	249	1	The	the	DT
cord-270337-92a5uwjf	249	2	in	in	IN
cord-270337-92a5uwjf	249	3	vivo	vivo	NN
cord-270337-92a5uwjf	249	4	experimental	experimental	JJ
cord-270337-92a5uwjf	249	5	models	model	NNS
cord-270337-92a5uwjf	249	6	of	of	IN
cord-270337-92a5uwjf	249	7	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	249	8	toxicity	toxicity	NN
cord-270337-92a5uwjf	249	9	indicated	indicate	VBD
cord-270337-92a5uwjf	249	10	that	that	IN
cord-270337-92a5uwjf	249	11	impaired	impair	VBN
cord-270337-92a5uwjf	249	12	cardiac	cardiac	JJ
cord-270337-92a5uwjf	249	13	contractility	contractility	NN
cord-270337-92a5uwjf	249	14	was	be	VBD
cord-270337-92a5uwjf	249	15	the	the	DT
cord-270337-92a5uwjf	249	16	primary	primary	JJ
cord-270337-92a5uwjf	249	17	event	event	NN
cord-270337-92a5uwjf	249	18	in	in	IN
cord-270337-92a5uwjf	249	19	the	the	DT
cord-270337-92a5uwjf	249	20	sequalae	sequalae	NNS
cord-270337-92a5uwjf	249	21	of	of	IN
cord-270337-92a5uwjf	249	22	toxicity	toxicity	NN
cord-270337-92a5uwjf	249	23	.	.	.
cord-270337-92a5uwjf	250	1	Hypotension	hypotension	NN
cord-270337-92a5uwjf	250	2	,	,	,
cord-270337-92a5uwjf	250	3	bradycardia	bradycardia	NN
cord-270337-92a5uwjf	250	4	,	,	,
cord-270337-92a5uwjf	250	5	changes	change	NNS
cord-270337-92a5uwjf	250	6	in	in	IN
cord-270337-92a5uwjf	250	7	ECG	ECG	NNP
cord-270337-92a5uwjf	250	8	intervals	interval	NNS
cord-270337-92a5uwjf	250	9	,	,	,
cord-270337-92a5uwjf	250	10	arrhythmias	arrhythmia	NNS
cord-270337-92a5uwjf	250	11	and	and	CC
cord-270337-92a5uwjf	250	12	death	death	NN
cord-270337-92a5uwjf	250	13	followed	follow	VBD
cord-270337-92a5uwjf	250	14	in	in	IN
cord-270337-92a5uwjf	250	15	a	a	DT
cord-270337-92a5uwjf	250	16	similar	similar	JJ
cord-270337-92a5uwjf	250	17	manner	manner	NN
cord-270337-92a5uwjf	250	18	as	as	IN
cord-270337-92a5uwjf	250	19	described	describe	VBN
cord-270337-92a5uwjf	250	20	previously	previously	RB
cord-270337-92a5uwjf	250	21	(	(	-LRB-
cord-270337-92a5uwjf	250	22	Sofola	Sofola	NNP
cord-270337-92a5uwjf	250	23	,	,	,
cord-270337-92a5uwjf	250	24	1980	1980	CD
cord-270337-92a5uwjf	250	25	)	)	-RRB-
cord-270337-92a5uwjf	250	26	.	.	.
cord-270337-92a5uwjf	251	1	However	however	RB
cord-270337-92a5uwjf	251	2	,	,	,
cord-270337-92a5uwjf	251	3	cardiac	cardiac	NN
cord-270337-92a5uwjf	251	4	arrhythmias	arrhythmia	NNS
cord-270337-92a5uwjf	251	5	may	may	MD
cord-270337-92a5uwjf	251	6	be	be	VB
cord-270337-92a5uwjf	251	7	less	less	RBR
cord-270337-92a5uwjf	251	8	prevalent	prevalent	JJ
cord-270337-92a5uwjf	251	9	in	in	IN
cord-270337-92a5uwjf	251	10	cases	case	NNS
cord-270337-92a5uwjf	251	11	of	of	IN
cord-270337-92a5uwjf	251	12	human	human	JJ
cord-270337-92a5uwjf	251	13	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	251	14	poisoning	poisoning	NN
cord-270337-92a5uwjf	251	15	which	which	WDT
cord-270337-92a5uwjf	251	16	occurs	occur	VBZ
cord-270337-92a5uwjf	251	17	following	follow	VBG
cord-270337-92a5uwjf	251	18	oral	oral	JJ
cord-270337-92a5uwjf	251	19	ingestion	ingestion	NN
cord-270337-92a5uwjf	251	20	(	(	-LRB-
cord-270337-92a5uwjf	251	21	absorption	absorption	NN
cord-270337-92a5uwjf	251	22	half	half	JJ
cord-270337-92a5uwjf	251	23	-	-	HYPH
cord-270337-92a5uwjf	251	24	life	life	NN
cord-270337-92a5uwjf	251	25	$	$	$
cord-270337-92a5uwjf	251	26	20	20	CD
cord-270337-92a5uwjf	251	27	min	min	NN
cord-270337-92a5uwjf	251	28	)	)	-RRB-
cord-270337-92a5uwjf	251	29	and	and	CC
cord-270337-92a5uwjf	251	30	where	where	WRB
cord-270337-92a5uwjf	251	31	blood	blood	NN
cord-270337-92a5uwjf	251	32	concentrations	concentration	NNS
cord-270337-92a5uwjf	251	33	are	be	VBP
cord-270337-92a5uwjf	251	34	predominantly	predominantly	RB
cord-270337-92a5uwjf	251	35	governed	govern	VBN
cord-270337-92a5uwjf	251	36	by	by	IN
cord-270337-92a5uwjf	251	37	the	the	DT
cord-270337-92a5uwjf	251	38	distribution	distribution	NN
cord-270337-92a5uwjf	251	39	and	and	CC
cord-270337-92a5uwjf	251	40	redistribution	redistribution	NN
cord-270337-92a5uwjf	251	41	processes	process	NNS
cord-270337-92a5uwjf	251	42	from	from	IN
cord-270337-92a5uwjf	251	43	the	the	DT
cord-270337-92a5uwjf	251	44	various	various	JJ
cord-270337-92a5uwjf	251	45	body	body	NN
cord-270337-92a5uwjf	251	46	compartments	compartment	NNS
cord-270337-92a5uwjf	251	47	back	back	RB
cord-270337-92a5uwjf	251	48	to	to	IN
cord-270337-92a5uwjf	251	49	the	the	DT
cord-270337-92a5uwjf	251	50	intravascular	intravascular	JJ
cord-270337-92a5uwjf	251	51	space	space	NN
cord-270337-92a5uwjf	251	52	(	(	-LRB-
cord-270337-92a5uwjf	251	53	Mégarbane	Mégarbane	NNP
cord-270337-92a5uwjf	251	54	et	et	NNP
cord-270337-92a5uwjf	251	55	al	al	NNP
cord-270337-92a5uwjf	251	56	.	.	NNP
cord-270337-92a5uwjf	251	57	,	,	,
cord-270337-92a5uwjf	251	58	2010	2010	CD
cord-270337-92a5uwjf	251	59	)	)	-RRB-
cord-270337-92a5uwjf	251	60	.	.	.
cord-270337-92a5uwjf	252	1	Differences	difference	NNS
cord-270337-92a5uwjf	252	2	between	between	IN
cord-270337-92a5uwjf	252	3	species	specie	NNS
cord-270337-92a5uwjf	252	4	in	in	IN
cord-270337-92a5uwjf	252	5	cardiac	cardiac	JJ
cord-270337-92a5uwjf	252	6	electrophysiology	electrophysiology	NN
cord-270337-92a5uwjf	252	7	may	may	MD
cord-270337-92a5uwjf	252	8	also	also	RB
cord-270337-92a5uwjf	252	9	explain	explain	VB
cord-270337-92a5uwjf	252	10	varying	vary	VBG
cord-270337-92a5uwjf	252	11	arrhythmic	arrhythmic	JJ
cord-270337-92a5uwjf	252	12	manifestations	manifestation	NNS
cord-270337-92a5uwjf	252	13	.	.	.
cord-270337-92a5uwjf	253	1	The	the	DT
cord-270337-92a5uwjf	253	2	provision	provision	NN
cord-270337-92a5uwjf	253	3	of	of	IN
cord-270337-92a5uwjf	253	4	mechanical	mechanical	JJ
cord-270337-92a5uwjf	253	5	ventilation	ventilation	NN
cord-270337-92a5uwjf	253	6	did	do	VBD
cord-270337-92a5uwjf	253	7	not	not	RB
cord-270337-92a5uwjf	253	8	appear	appear	VB
cord-270337-92a5uwjf	253	9	to	to	TO
cord-270337-92a5uwjf	253	10	influence	influence	VB
cord-270337-92a5uwjf	253	11	the	the	DT
cord-270337-92a5uwjf	253	12	onset	onset	NN
cord-270337-92a5uwjf	253	13	or	or	CC
cord-270337-92a5uwjf	253	14	the	the	DT
cord-270337-92a5uwjf	253	15	severity	severity	NN
cord-270337-92a5uwjf	253	16	of	of	IN
cord-270337-92a5uwjf	253	17	these	these	DT
cord-270337-92a5uwjf	253	18	effects	effect	NNS
cord-270337-92a5uwjf	253	19	.	.	.
cord-270337-92a5uwjf	254	1	Significant	significant	JJ
cord-270337-92a5uwjf	254	2	changes	change	NNS
cord-270337-92a5uwjf	254	3	in	in	IN
cord-270337-92a5uwjf	254	4	cardiovascular	cardiovascular	JJ
cord-270337-92a5uwjf	254	5	function	function	NN
cord-270337-92a5uwjf	254	6	occurred	occur	VBD
cord-270337-92a5uwjf	254	7	in	in	IN
cord-270337-92a5uwjf	254	8	the	the	DT
cord-270337-92a5uwjf	254	9	absence	absence	NN
cord-270337-92a5uwjf	254	10	of	of	IN
cord-270337-92a5uwjf	254	11	changes	change	NNS
cord-270337-92a5uwjf	254	12	in	in	IN
cord-270337-92a5uwjf	254	13	either	either	DT
cord-270337-92a5uwjf	254	14	arterial	arterial	JJ
cord-270337-92a5uwjf	254	15	blood	blood	NN
cord-270337-92a5uwjf	254	16	gas	gas	NN
cord-270337-92a5uwjf	254	17	levels	level	NNS
cord-270337-92a5uwjf	254	18	or	or	CC
cord-270337-92a5uwjf	254	19	pH	ph	NN
cord-270337-92a5uwjf	254	20	,	,	,
cord-270337-92a5uwjf	254	21	suggesting	suggest	VBG
cord-270337-92a5uwjf	254	22	that	that	IN
cord-270337-92a5uwjf	254	23	toxic	toxic	JJ
cord-270337-92a5uwjf	254	24	manifestations	manifestation	NNS
cord-270337-92a5uwjf	254	25	due	due	JJ
cord-270337-92a5uwjf	254	26	to	to	IN
cord-270337-92a5uwjf	254	27	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	254	28	are	be	VBP
cord-270337-92a5uwjf	254	29	not	not	RB
cord-270337-92a5uwjf	254	30	secondary	secondary	JJ
cord-270337-92a5uwjf	254	31	to	to	IN
cord-270337-92a5uwjf	254	32	hypoxia	hypoxia	NN
cord-270337-92a5uwjf	254	33	.	.	.
cord-270337-92a5uwjf	255	1	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	255	2	was	be	VBD
cord-270337-92a5uwjf	255	3	about	about	RB
cord-270337-92a5uwjf	255	4	twice	twice	PDT
cord-270337-92a5uwjf	255	5	as	as	RB
cord-270337-92a5uwjf	255	6	potent	potent	JJ
cord-270337-92a5uwjf	255	7	in	in	IN
cord-270337-92a5uwjf	255	8	its	-PRON-	PRP$
cord-270337-92a5uwjf	255	9	toxic	toxic	JJ
cord-270337-92a5uwjf	255	10	effects	effect	NNS
cord-270337-92a5uwjf	255	11	in	in	IN
cord-270337-92a5uwjf	255	12	rabbits	rabbit	NNS
cord-270337-92a5uwjf	255	13	than	than	IN
cord-270337-92a5uwjf	255	14	in	in	IN
cord-270337-92a5uwjf	255	15	rats	rat	NNS
cord-270337-92a5uwjf	255	16	(	(	-LRB-
cord-270337-92a5uwjf	255	17	on	on	IN
cord-270337-92a5uwjf	255	18	a	a	DT
cord-270337-92a5uwjf	255	19	mgÁkg	mgákg	JJ
cord-270337-92a5uwjf	255	20	−1	−1	NNP
cord-270337-92a5uwjf	255	21	basis	basis	NN
cord-270337-92a5uwjf	255	22	)	)	-RRB-
cord-270337-92a5uwjf	255	23	,	,	,
cord-270337-92a5uwjf	255	24	where	where	WRB
cord-270337-92a5uwjf	255	25	whole	whole	JJ
cord-270337-92a5uwjf	255	26	blood	blood	NN
cord-270337-92a5uwjf	255	27	concentrations	concentration	NNS
cord-270337-92a5uwjf	255	28	were	be	VBD
cord-270337-92a5uwjf	255	29	within	within	IN
cord-270337-92a5uwjf	255	30	the	the	DT
cord-270337-92a5uwjf	255	31	10	10	CD
cord-270337-92a5uwjf	255	32	-	-	SYM
cord-270337-92a5uwjf	255	33	20	20	CD
cord-270337-92a5uwjf	255	34	μM	μm	CD
cord-270337-92a5uwjf	255	35	range	range	NN
cord-270337-92a5uwjf	255	36	.	.	.
cord-270337-92a5uwjf	256	1	This	this	DT
cord-270337-92a5uwjf	256	2	concentration	concentration	NN
cord-270337-92a5uwjf	256	3	range	range	NN
cord-270337-92a5uwjf	256	4	is	be	VBZ
cord-270337-92a5uwjf	256	5	comparable	comparable	JJ
cord-270337-92a5uwjf	256	6	with	with	IN
cord-270337-92a5uwjf	256	7	the	the	DT
cord-270337-92a5uwjf	256	8	concentrations	concentration	NNS
cord-270337-92a5uwjf	256	9	used	use	VBN
cord-270337-92a5uwjf	256	10	in	in	IN
cord-270337-92a5uwjf	256	11	the	the	DT
cord-270337-92a5uwjf	256	12	in	in	FW
cord-270337-92a5uwjf	256	13	vitro	vitro	FW
cord-270337-92a5uwjf	256	14	experiments	experiment	NNS
cord-270337-92a5uwjf	256	15	and	and	CC
cord-270337-92a5uwjf	256	16	observed	observe	VBD
cord-270337-92a5uwjf	256	17	in	in	IN
cord-270337-92a5uwjf	256	18	human	human	JJ
cord-270337-92a5uwjf	256	19	toxicokinetic	toxicokinetic	NNP
cord-270337-92a5uwjf	256	20	studies	study	NNS
cord-270337-92a5uwjf	256	21	.	.	.
cord-270337-92a5uwjf	257	1	Clemessy	Clemessy	NNP
cord-270337-92a5uwjf	257	2	et	et	FW
cord-270337-92a5uwjf	257	3	al	al	NNP
cord-270337-92a5uwjf	257	4	.	.	.
cord-270337-92a5uwjf	258	1	(	(	-LRB-
cord-270337-92a5uwjf	258	2	1995	1995	CD
cord-270337-92a5uwjf	258	3	)	)	-RRB-
cord-270337-92a5uwjf	258	4	reported	report	VBD
cord-270337-92a5uwjf	258	5	a	a	DT
cord-270337-92a5uwjf	258	6	mean	mean	JJ
cord-270337-92a5uwjf	258	7	whole	whole	JJ
cord-270337-92a5uwjf	258	8	blood	blood	NN
cord-270337-92a5uwjf	258	9	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	258	10	concentration	concentration	NN
cord-270337-92a5uwjf	258	11	of	of	IN
cord-270337-92a5uwjf	258	12	20.1	20.1	CD
cord-270337-92a5uwjf	258	13	μM	μM	NNP
cord-270337-92a5uwjf	258	14	(	(	-LRB-
cord-270337-92a5uwjf	258	15	range	range	NN
cord-270337-92a5uwjf	258	16	1.8	1.8	CD
cord-270337-92a5uwjf	258	17	to	to	IN
cord-270337-92a5uwjf	258	18	78	78	CD
cord-270337-92a5uwjf	258	19	μM	μM	NNP
cord-270337-92a5uwjf	258	20	)	)	-RRB-
cord-270337-92a5uwjf	258	21	among	among	IN
cord-270337-92a5uwjf	258	22	191	191	CD
cord-270337-92a5uwjf	258	23	patients	patient	NNS
cord-270337-92a5uwjf	258	24	admitted	admit	VBN
cord-270337-92a5uwjf	258	25	to	to	IN
cord-270337-92a5uwjf	258	26	intensive	intensive	JJ
cord-270337-92a5uwjf	258	27	care	care	NN
cord-270337-92a5uwjf	258	28	.	.	.
cord-270337-92a5uwjf	259	1	Mégarbane	Mégarbane	NNP
cord-270337-92a5uwjf	259	2	et	et	NNP
cord-270337-92a5uwjf	259	3	al	al	NNP
cord-270337-92a5uwjf	259	4	.	.	.
cord-270337-92a5uwjf	260	1	(	(	-LRB-
cord-270337-92a5uwjf	260	2	2010	2010	CD
cord-270337-92a5uwjf	260	3	)	)	-RRB-
cord-270337-92a5uwjf	260	4	correlated	correlate	VBD
cord-270337-92a5uwjf	260	5	mild	mild	JJ
cord-270337-92a5uwjf	260	6	cardiotoxicity	cardiotoxicity	NN
cord-270337-92a5uwjf	260	7	with	with	IN
cord-270337-92a5uwjf	260	8	peak	peak	NN
cord-270337-92a5uwjf	260	9	concentrations	concentration	NNS
cord-270337-92a5uwjf	260	10	≤16	≤16	NNP
cord-270337-92a5uwjf	261	1	μM	μM	NNP
cord-270337-92a5uwjf	261	2	,	,	,
cord-270337-92a5uwjf	261	3	moderate	moderate	JJ
cord-270337-92a5uwjf	261	4	16	16	CD
cord-270337-92a5uwjf	261	5	-	-	SYM
cord-270337-92a5uwjf	261	6	25	25	CD
cord-270337-92a5uwjf	261	7	μM	μm	CD
cord-270337-92a5uwjf	262	1	and	and	CC
cord-270337-92a5uwjf	262	2	severe	severe	JJ
cord-270337-92a5uwjf	263	1	>	>	XX
cord-270337-92a5uwjf	264	1	25	25	CD
cord-270337-92a5uwjf	265	1	μM.	μM.	NNP
cord-270337-92a5uwjf	265	2	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	265	3	is	be	VBZ
cord-270337-92a5uwjf	265	4	extensively	extensively	RB
cord-270337-92a5uwjf	265	5	distributed	distribute	VBN
cord-270337-92a5uwjf	265	6	to	to	IN
cord-270337-92a5uwjf	265	7	extravascular	extravascular	JJ
cord-270337-92a5uwjf	265	8	tissues	tissue	NNS
cord-270337-92a5uwjf	265	9	and	and	CC
cord-270337-92a5uwjf	265	10	some	some	DT
cord-270337-92a5uwjf	265	11	reversal	reversal	NN
cord-270337-92a5uwjf	265	12	of	of	IN
cord-270337-92a5uwjf	265	13	cardiotoxicity	cardiotoxicity	NN
cord-270337-92a5uwjf	265	14	would	would	MD
cord-270337-92a5uwjf	265	15	be	be	VB
cord-270337-92a5uwjf	265	16	expected	expect	VBN
cord-270337-92a5uwjf	265	17	upon	upon	IN
cord-270337-92a5uwjf	265	18	cessation	cessation	NN
cord-270337-92a5uwjf	265	19	of	of	IN
cord-270337-92a5uwjf	265	20	administration	administration	NN
cord-270337-92a5uwjf	265	21	.	.	.
cord-270337-92a5uwjf	266	1	The	the	DT
cord-270337-92a5uwjf	266	2	in	in	IN
cord-270337-92a5uwjf	266	3	vivo	vivo	NN
cord-270337-92a5uwjf	266	4	experimental	experimental	JJ
cord-270337-92a5uwjf	266	5	models	model	NNS
cord-270337-92a5uwjf	266	6	of	of	IN
cord-270337-92a5uwjf	266	7	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	266	8	toxicity	toxicity	NN
cord-270337-92a5uwjf	266	9	did	do	VBD
cord-270337-92a5uwjf	266	10	not	not	RB
cord-270337-92a5uwjf	266	11	test	test	VB
cord-270337-92a5uwjf	266	12	this	this	DT
cord-270337-92a5uwjf	266	13	.	.	.
cord-270337-92a5uwjf	267	1	However	however	RB
cord-270337-92a5uwjf	267	2	,	,	,
cord-270337-92a5uwjf	267	3	in	in	IN
cord-270337-92a5uwjf	267	4	experiment	experiment	NN
cord-270337-92a5uwjf	267	5	(	(	-LRB-
cord-270337-92a5uwjf	267	6	iii	iii	NNP
cord-270337-92a5uwjf	267	7	)	)	-RRB-
cord-270337-92a5uwjf	267	8	,	,	,
cord-270337-92a5uwjf	267	9	the	the	DT
cord-270337-92a5uwjf	267	10	administration	administration	NN
cord-270337-92a5uwjf	267	11	of	of	IN
cord-270337-92a5uwjf	267	12	chloroquine	chloroquine	NNP
cord-270337-92a5uwjf	267	13	(	(	-LRB-
cord-270337-92a5uwjf	267	14	2	2	CD
cord-270337-92a5uwjf	267	15	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	267	16	−1	−1	NNP
cord-270337-92a5uwjf	268	1	Ámin	Ámin	NNP
cord-270337-92a5uwjf	268	2	−1	−1	NNP
cord-270337-92a5uwjf	268	3	i.v	i.v	NNP
cord-270337-92a5uwjf	268	4	.	.	NNP
cord-270337-92a5uwjf	268	5	)	)	-RRB-
cord-270337-92a5uwjf	268	6	ceased	cease	VBD
cord-270337-92a5uwjf	268	7	after	after	IN
cord-270337-92a5uwjf	268	8	15	15	CD
cord-270337-92a5uwjf	268	9	min	min	NN
cord-270337-92a5uwjf	268	10	and	and	CC
cord-270337-92a5uwjf	268	11	recovery	recovery	NN
cord-270337-92a5uwjf	268	12	in	in	IN
cord-270337-92a5uwjf	268	13	cardiovascular	cardiovascular	JJ
cord-270337-92a5uwjf	268	14	parameters	parameter	NNS
cord-270337-92a5uwjf	268	15	was	be	VBD
cord-270337-92a5uwjf	268	16	observed	observe	VBN
cord-270337-92a5uwjf	268	17	in	in	IN
cord-270337-92a5uwjf	268	18	all	all	DT
cord-270337-92a5uwjf	268	19	treatment	treatment	NN
cord-270337-92a5uwjf	268	20	/	/	SYM
cord-270337-92a5uwjf	268	21	vehicle	vehicle	NN
cord-270337-92a5uwjf	268	22	groups	group	NNS
cord-270337-92a5uwjf	268	23	.	.	.
cord-270337-92a5uwjf	269	1	The	the	DT
cord-270337-92a5uwjf	269	2	series	series	NN
cord-270337-92a5uwjf	269	3	of	of	IN
cord-270337-92a5uwjf	269	4	randomised	randomised	JJ
cord-270337-92a5uwjf	269	5	controlled	control	VBN
cord-270337-92a5uwjf	269	6	trials	trial	NNS
cord-270337-92a5uwjf	269	7	was	be	VBD
cord-270337-92a5uwjf	269	8	designed	design	VBN
cord-270337-92a5uwjf	269	9	to	to	TO
cord-270337-92a5uwjf	269	10	assess	assess	VB
cord-270337-92a5uwjf	269	11	whether	whether	IN
cord-270337-92a5uwjf	269	12	modulation	modulation	NN
cord-270337-92a5uwjf	269	13	of	of	IN
cord-270337-92a5uwjf	269	14	the	the	DT
cord-270337-92a5uwjf	269	15	GABA	GABA	NNP
cord-270337-92a5uwjf	269	16	A	A	NNP
cord-270337-92a5uwjf	269	17	receptor	receptor	NN
cord-270337-92a5uwjf	269	18	or	or	CC
cord-270337-92a5uwjf	269	19	other	other	JJ
cord-270337-92a5uwjf	269	20	effects	effect	NNS
cord-270337-92a5uwjf	269	21	of	of	IN
cord-270337-92a5uwjf	269	22	diazepam	diazepam	NN
cord-270337-92a5uwjf	269	23	might	may	MD
cord-270337-92a5uwjf	269	24	account	account	VB
cord-270337-92a5uwjf	269	25	for	for	IN
cord-270337-92a5uwjf	269	26	previous	previous	JJ
cord-270337-92a5uwjf	269	27	reports	report	NNS
cord-270337-92a5uwjf	269	28	of	of	IN
cord-270337-92a5uwjf	269	29	reduced	reduce	VBN
cord-270337-92a5uwjf	269	30	toxicity	toxicity	NN
cord-270337-92a5uwjf	269	31	with	with	IN
cord-270337-92a5uwjf	269	32	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	269	33	.	.	.
cord-270337-92a5uwjf	270	1	However	however	RB
cord-270337-92a5uwjf	270	2	,	,	,
cord-270337-92a5uwjf	270	3	diazepam	diazepam	NN
cord-270337-92a5uwjf	270	4	,	,	,
cord-270337-92a5uwjf	270	5	whether	whether	IN
cord-270337-92a5uwjf	270	6	administered	administer	VBN
cord-270337-92a5uwjf	270	7	prior	prior	RB
cord-270337-92a5uwjf	270	8	,	,	,
cord-270337-92a5uwjf	270	9	during	during	IN
cord-270337-92a5uwjf	270	10	or	or	CC
cord-270337-92a5uwjf	270	11	after	after	IN
cord-270337-92a5uwjf	270	12	the	the	DT
cord-270337-92a5uwjf	270	13	administration	administration	NN
cord-270337-92a5uwjf	270	14	of	of	IN
cord-270337-92a5uwjf	270	15	chloroquine	chloroquine	NNP
cord-270337-92a5uwjf	270	16	or	or	CC
cord-270337-92a5uwjf	270	17	at	at	IN
cord-270337-92a5uwjf	270	18	high	high	JJ
cord-270337-92a5uwjf	270	19	dose	dose	NN
cord-270337-92a5uwjf	270	20	,	,	,
cord-270337-92a5uwjf	270	21	failed	fail	VBD
cord-270337-92a5uwjf	270	22	to	to	TO
cord-270337-92a5uwjf	270	23	attenuate	attenuate	VB
cord-270337-92a5uwjf	270	24	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	270	25	-	-	HYPH
cord-270337-92a5uwjf	270	26	induced	induce	VBN
cord-270337-92a5uwjf	270	27	cardiotoxicity	cardiotoxicity	NN
cord-270337-92a5uwjf	270	28	in	in	IN
cord-270337-92a5uwjf	270	29	anaesthetised	anaesthetised	JJ
cord-270337-92a5uwjf	270	30	rats	rat	NNS
cord-270337-92a5uwjf	270	31	.	.	.
cord-270337-92a5uwjf	271	1	These	these	DT
cord-270337-92a5uwjf	271	2	results	result	NNS
cord-270337-92a5uwjf	271	3	are	be	VBP
cord-270337-92a5uwjf	271	4	consistent	consistent	JJ
cord-270337-92a5uwjf	271	5	with	with	IN
cord-270337-92a5uwjf	271	6	previous	previous	JJ
cord-270337-92a5uwjf	271	7	studies	study	NNS
cord-270337-92a5uwjf	271	8	in	in	IN
cord-270337-92a5uwjf	271	9	spontaneously	spontaneously	RB
cord-270337-92a5uwjf	271	10	breathing	breathe	VBG
cord-270337-92a5uwjf	271	11	rats	rat	NNS
cord-270337-92a5uwjf	271	12	anaesthetised	anaesthetise	VBN
cord-270337-92a5uwjf	271	13	with	with	IN
cord-270337-92a5uwjf	271	14	thiobutobarbitone	thiobutobarbitone	NNP
cord-270337-92a5uwjf	271	15	(	(	-LRB-
cord-270337-92a5uwjf	271	16	Buckley	Buckley	NNP
cord-270337-92a5uwjf	271	17	et	et	NNP
cord-270337-92a5uwjf	271	18	al	al	NNP
cord-270337-92a5uwjf	271	19	.	.	NNP
cord-270337-92a5uwjf	271	20	,	,	,
cord-270337-92a5uwjf	271	21	1996	1996	CD
cord-270337-92a5uwjf	271	22	)	)	-RRB-
cord-270337-92a5uwjf	271	23	,	,	,
cord-270337-92a5uwjf	271	24	but	but	CC
cord-270337-92a5uwjf	271	25	contrast	contrast	NN
cord-270337-92a5uwjf	271	26	with	with	IN
cord-270337-92a5uwjf	271	27	experiments	experiment	NNS
cord-270337-92a5uwjf	271	28	performed	perform	VBN
cord-270337-92a5uwjf	271	29	in	in	IN
cord-270337-92a5uwjf	271	30	conscious	conscious	JJ
cord-270337-92a5uwjf	271	31	rats	rat	NNS
cord-270337-92a5uwjf	271	32	(	(	-LRB-
cord-270337-92a5uwjf	271	33	Crouzette	Crouzette	NNP
cord-270337-92a5uwjf	271	34	et	et	NNP
cord-270337-92a5uwjf	271	35	al	al	NNP
cord-270337-92a5uwjf	271	36	.	.	NNP
cord-270337-92a5uwjf	271	37	,	,	,
cord-270337-92a5uwjf	271	38	1983	1983	CD
cord-270337-92a5uwjf	271	39	)	)	-RRB-
cord-270337-92a5uwjf	271	40	and	and	CC
cord-270337-92a5uwjf	271	41	pentobarbitone	pentobarbitone	NN
cord-270337-92a5uwjf	271	42	-	-	HYPH
cord-270337-92a5uwjf	271	43	anesthetised	anesthetised	JJ
cord-270337-92a5uwjf	271	44	,	,	,
cord-270337-92a5uwjf	271	45	mechanically	mechanically	RB
cord-270337-92a5uwjf	271	46	ventilated	ventilate	VBN
cord-270337-92a5uwjf	271	47	pigs	pig	NNS
cord-270337-92a5uwjf	271	48	.	.	.
cord-270337-92a5uwjf	272	1	Possible	possible	JJ
cord-270337-92a5uwjf	272	2	explanations	explanation	NNS
cord-270337-92a5uwjf	272	3	for	for	IN
cord-270337-92a5uwjf	272	4	these	these	DT
cord-270337-92a5uwjf	272	5	discrepancies	discrepancy	NNS
cord-270337-92a5uwjf	272	6	might	may	MD
cord-270337-92a5uwjf	272	7	include	include	VB
cord-270337-92a5uwjf	272	8	the	the	DT
cord-270337-92a5uwjf	272	9	choice	choice	NN
cord-270337-92a5uwjf	272	10	of	of	IN
cord-270337-92a5uwjf	272	11	species	specie	NNS
cord-270337-92a5uwjf	272	12	,	,	,
cord-270337-92a5uwjf	272	13	doses	dose	NNS
cord-270337-92a5uwjf	272	14	of	of	IN
cord-270337-92a5uwjf	272	15	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	272	16	and	and	CC
cord-270337-92a5uwjf	272	17	diazepam	diazepam	NN
cord-270337-92a5uwjf	272	18	,	,	,
cord-270337-92a5uwjf	272	19	and	and	CC
cord-270337-92a5uwjf	272	20	anaesthesia	anaesthesia	NN
cord-270337-92a5uwjf	272	21	.	.	.
cord-270337-92a5uwjf	273	1	Based	base	VBN
cord-270337-92a5uwjf	273	2	on	on	IN
cord-270337-92a5uwjf	273	3	allometric	allometric	JJ
cord-270337-92a5uwjf	273	4	scaling	scaling	NN
cord-270337-92a5uwjf	273	5	to	to	IN
cord-270337-92a5uwjf	273	6	human	human	JJ
cord-270337-92a5uwjf	273	7	doses	dose	NNS
cord-270337-92a5uwjf	273	8	,	,	,
cord-270337-92a5uwjf	273	9	2	2	CD
cord-270337-92a5uwjf	273	10	and	and	CC
cord-270337-92a5uwjf	273	11	10	10	CD
cord-270337-92a5uwjf	273	12	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	273	13	−1	−1	NNP
cord-270337-92a5uwjf	273	14	of	of	IN
cord-270337-92a5uwjf	273	15	diazepam	diazepam	NNP
cord-270337-92a5uwjf	273	16	administered	administer	VBN
cord-270337-92a5uwjf	273	17	to	to	IN
cord-270337-92a5uwjf	273	18	rats	rat	NNS
cord-270337-92a5uwjf	273	19	correspond	correspond	VB
cord-270337-92a5uwjf	273	20	to	to	IN
cord-270337-92a5uwjf	273	21	0.3	0.3	CD
cord-270337-92a5uwjf	273	22	and	and	CC
cord-270337-92a5uwjf	273	23	1.6	1.6	CD
cord-270337-92a5uwjf	273	24	mgÁkg	mgÁkg	NNP
cord-270337-92a5uwjf	273	25	−1	−1	NNP
cord-270337-92a5uwjf	273	26	in	in	IN
cord-270337-92a5uwjf	273	27	adults	adult	NNS
cord-270337-92a5uwjf	273	28	.	.	.
cord-270337-92a5uwjf	274	1	Effects	effect	NNS
cord-270337-92a5uwjf	274	2	were	be	VBD
cord-270337-92a5uwjf	274	3	similar	similar	JJ
cord-270337-92a5uwjf	274	4	in	in	IN
cord-270337-92a5uwjf	274	5	the	the	DT
cord-270337-92a5uwjf	274	6	trial	trial	NN
cord-270337-92a5uwjf	274	7	in	in	IN
cord-270337-92a5uwjf	274	8	which	which	WDT
cord-270337-92a5uwjf	274	9	urethane	urethane	NN
cord-270337-92a5uwjf	274	10	was	be	VBD
cord-270337-92a5uwjf	274	11	chosen	choose	VBN
cord-270337-92a5uwjf	274	12	as	as	IN
cord-270337-92a5uwjf	274	13	an	an	DT
cord-270337-92a5uwjf	274	14	anaesthetic	anaesthetic	NN
cord-270337-92a5uwjf	274	15	for	for	IN
cord-270337-92a5uwjf	274	16	its	-PRON-	PRP$
cord-270337-92a5uwjf	274	17	lack	lack	NN
cord-270337-92a5uwjf	274	18	of	of	IN
cord-270337-92a5uwjf	274	19	interaction	interaction	NN
cord-270337-92a5uwjf	274	20	with	with	IN
cord-270337-92a5uwjf	274	21	GABA	GABA	NNP
cord-270337-92a5uwjf	274	22	A	A	NNP
cord-270337-92a5uwjf	274	23	receptors	receptor	NNS
cord-270337-92a5uwjf	274	24	.	.	.
cord-270337-92a5uwjf	275	1	Experiments	experiment	NNS
cord-270337-92a5uwjf	275	2	aimed	aim	VBD
cord-270337-92a5uwjf	275	3	to	to	TO
cord-270337-92a5uwjf	275	4	differentiate	differentiate	VB
cord-270337-92a5uwjf	275	5	any	any	DT
cord-270337-92a5uwjf	275	6	GABA	GABA	NNP
cord-270337-92a5uwjf	275	7	mediated	mediate	VBN
cord-270337-92a5uwjf	275	8	versus	versus	IN
cord-270337-92a5uwjf	275	9	other	other	JJ
cord-270337-92a5uwjf	275	10	effects	effect	NNS
cord-270337-92a5uwjf	275	11	of	of	IN
cord-270337-92a5uwjf	275	12	diazepam	diazepam	NN
cord-270337-92a5uwjf	275	13	,	,	,
cord-270337-92a5uwjf	275	14	used	use	VBD
cord-270337-92a5uwjf	275	15	Ro5	ro5	NN
cord-270337-92a5uwjf	275	16	-	-	HYPH
cord-270337-92a5uwjf	275	17	4864	4864	CD
cord-270337-92a5uwjf	275	18	,	,	,
cord-270337-92a5uwjf	275	19	which	which	WDT
cord-270337-92a5uwjf	275	20	has	have	VBZ
cord-270337-92a5uwjf	275	21	activity	activity	NN
cord-270337-92a5uwjf	275	22	at	at	IN
cord-270337-92a5uwjf	275	23	the	the	DT
cord-270337-92a5uwjf	275	24	mitochondrial	mitochondrial	JJ
cord-270337-92a5uwjf	275	25	TSPO	TSPO	NNP
cord-270337-92a5uwjf	275	26	benzodiazepine	benzodiazepine	NN
cord-270337-92a5uwjf	275	27	binding	binding	NN
cord-270337-92a5uwjf	275	28	site	site	NN
cord-270337-92a5uwjf	275	29	distinct	distinct	JJ
cord-270337-92a5uwjf	275	30	from	from	IN
cord-270337-92a5uwjf	275	31	the	the	DT
cord-270337-92a5uwjf	275	32	GABA	GABA	NNP
cord-270337-92a5uwjf	275	33	A	A	NNP
cord-270337-92a5uwjf	275	34	receptors	receptor	NNS
cord-270337-92a5uwjf	275	35	in	in	IN
cord-270337-92a5uwjf	275	36	the	the	DT
cord-270337-92a5uwjf	275	37	CNS	CNS	NNP
cord-270337-92a5uwjf	275	38	and	and	CC
cord-270337-92a5uwjf	275	39	clonazepam	clonazepam	NN
cord-270337-92a5uwjf	275	40	,	,	,
cord-270337-92a5uwjf	275	41	which	which	WDT
cord-270337-92a5uwjf	275	42	rapidly	rapidly	RB
cord-270337-92a5uwjf	275	43	crosses	cross	VBZ
cord-270337-92a5uwjf	275	44	the	the	DT
cord-270337-92a5uwjf	275	45	blood	blood	NN
cord-270337-92a5uwjf	275	46	-	-	HYPH
cord-270337-92a5uwjf	275	47	brain	brain	NN
cord-270337-92a5uwjf	275	48	barrier	barrier	NN
cord-270337-92a5uwjf	275	49	and	and	CC
cord-270337-92a5uwjf	275	50	is	be	VBZ
cord-270337-92a5uwjf	275	51	a	a	DT
cord-270337-92a5uwjf	275	52	potent	potent	JJ
cord-270337-92a5uwjf	275	53	positive	positive	JJ
cord-270337-92a5uwjf	275	54	allosteric	allosteric	JJ
cord-270337-92a5uwjf	275	55	modulator	modulator	NN
cord-270337-92a5uwjf	275	56	of	of	IN
cord-270337-92a5uwjf	275	57	GABA	GABA	NNP
cord-270337-92a5uwjf	275	58	A	A	NNP
cord-270337-92a5uwjf	275	59	receptors	receptor	NNS
cord-270337-92a5uwjf	275	60	,	,	,
cord-270337-92a5uwjf	275	61	while	while	IN
cord-270337-92a5uwjf	275	62	having	have	VBG
cord-270337-92a5uwjf	275	63	low	low	JJ
cord-270337-92a5uwjf	275	64	affinity	affinity	NN
cord-270337-92a5uwjf	275	65	towards	towards	IN
cord-270337-92a5uwjf	275	66	TSPO	TSPO	NNP
cord-270337-92a5uwjf	275	67	.	.	.
cord-270337-92a5uwjf	276	1	Mitochondrial	mitochondrial	JJ
cord-270337-92a5uwjf	276	2	TSPO	TSPO	NNP
cord-270337-92a5uwjf	276	3	is	be	VBZ
cord-270337-92a5uwjf	276	4	ubiquitously	ubiquitously	RB
cord-270337-92a5uwjf	276	5	expressed	express	VBN
cord-270337-92a5uwjf	276	6	in	in	IN
cord-270337-92a5uwjf	276	7	various	various	JJ
cord-270337-92a5uwjf	276	8	tissues	tissue	NNS
cord-270337-92a5uwjf	276	9	,	,	,
cord-270337-92a5uwjf	276	10	including	include	VBG
cord-270337-92a5uwjf	276	11	the	the	DT
cord-270337-92a5uwjf	276	12	heart	heart	NN
cord-270337-92a5uwjf	276	13	with	with	IN
cord-270337-92a5uwjf	276	14	a	a	DT
cord-270337-92a5uwjf	276	15	putative	putative	JJ
cord-270337-92a5uwjf	276	16	role	role	NN
cord-270337-92a5uwjf	276	17	in	in	IN
cord-270337-92a5uwjf	276	18	regulating	regulate	VBG
cord-270337-92a5uwjf	276	19	heart	heart	NN
cord-270337-92a5uwjf	276	20	rate	rate	NN
cord-270337-92a5uwjf	276	21	and	and	CC
cord-270337-92a5uwjf	276	22	contractility	contractility	NN
cord-270337-92a5uwjf	276	23	(	(	-LRB-
cord-270337-92a5uwjf	276	24	Surinkaew	Surinkaew	NNP
cord-270337-92a5uwjf	276	25	,	,	,
cord-270337-92a5uwjf	276	26	Chattipakorn	Chattipakorn	NNP
cord-270337-92a5uwjf	276	27	,	,	,
cord-270337-92a5uwjf	276	28	&	&	CC
cord-270337-92a5uwjf	276	29	Chattipakorn	Chattipakorn	NNP
cord-270337-92a5uwjf	276	30	,	,	,
cord-270337-92a5uwjf	276	31	2011	2011	CD
cord-270337-92a5uwjf	276	32	)	)	-RRB-
cord-270337-92a5uwjf	276	33	.	.	.
cord-270337-92a5uwjf	277	1	As	as	IN
cord-270337-92a5uwjf	277	2	neither	neither	CC
cord-270337-92a5uwjf	277	3	diazepam	diazepam	NN
cord-270337-92a5uwjf	277	4	nor	nor	CC
cord-270337-92a5uwjf	277	5	either	either	DT
cord-270337-92a5uwjf	277	6	of	of	IN
cord-270337-92a5uwjf	277	7	these	these	DT
cord-270337-92a5uwjf	277	8	agents	agent	NNS
cord-270337-92a5uwjf	277	9	protected	protect	VBN
cord-270337-92a5uwjf	277	10	against	against	IN
cord-270337-92a5uwjf	277	11	or	or	CC
cord-270337-92a5uwjf	277	12	attenuated	attenuated	JJ
cord-270337-92a5uwjf	277	13	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	277	14	toxicity	toxicity	NN
cord-270337-92a5uwjf	277	15	,	,	,
cord-270337-92a5uwjf	277	16	it	-PRON-	PRP
cord-270337-92a5uwjf	277	17	is	be	VBZ
cord-270337-92a5uwjf	277	18	unlikely	unlikely	JJ
cord-270337-92a5uwjf	277	19	that	that	IN
cord-270337-92a5uwjf	277	20	any	any	DT
cord-270337-92a5uwjf	277	21	cardiovascular	cardiovascular	JJ
cord-270337-92a5uwjf	277	22	effects	effect	NNS
cord-270337-92a5uwjf	277	23	in	in	IN
cord-270337-92a5uwjf	277	24	the	the	DT
cord-270337-92a5uwjf	277	25	context	context	NN
cord-270337-92a5uwjf	277	26	of	of	IN
cord-270337-92a5uwjf	277	27	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	277	28	toxicity	toxicity	NN
cord-270337-92a5uwjf	277	29	can	can	MD
cord-270337-92a5uwjf	277	30	be	be	VB
cord-270337-92a5uwjf	277	31	attributed	attribute	VBN
cord-270337-92a5uwjf	277	32	to	to	IN
cord-270337-92a5uwjf	277	33	interaction	interaction	NN
cord-270337-92a5uwjf	277	34	with	with	IN
cord-270337-92a5uwjf	277	35	benzodiazepine	benzodiazepine	NN
cord-270337-92a5uwjf	277	36	binding	bind	VBG
cord-270337-92a5uwjf	277	37	sites	site	NNS
cord-270337-92a5uwjf	277	38	.	.	.
cord-270337-92a5uwjf	278	1	In	in	IN
cord-270337-92a5uwjf	278	2	view	view	NN
cord-270337-92a5uwjf	278	3	of	of	IN
cord-270337-92a5uwjf	278	4	the	the	DT
cord-270337-92a5uwjf	278	5	fact	fact	NN
cord-270337-92a5uwjf	278	6	that	that	IN
cord-270337-92a5uwjf	278	7	the	the	DT
cord-270337-92a5uwjf	278	8	principal	principal	JJ
cord-270337-92a5uwjf	278	9	adverse	adverse	JJ
cord-270337-92a5uwjf	278	10	effect	effect	NN
cord-270337-92a5uwjf	278	11	of	of	IN
cord-270337-92a5uwjf	278	12	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	278	13	is	be	VBZ
cord-270337-92a5uwjf	278	14	negative	negative	JJ
cord-270337-92a5uwjf	278	15	inotropy	inotropy	NNS
cord-270337-92a5uwjf	278	16	(	(	-LRB-
cord-270337-92a5uwjf	278	17	Sofola	Sofola	NNP
cord-270337-92a5uwjf	278	18	,	,	,
cord-270337-92a5uwjf	278	19	1980	1980	CD
cord-270337-92a5uwjf	278	20	)	)	-RRB-
cord-270337-92a5uwjf	278	21	and	and	CC
cord-270337-92a5uwjf	278	22	the	the	DT
cord-270337-92a5uwjf	278	23	absence	absence	NN
cord-270337-92a5uwjf	278	24	of	of	IN
cord-270337-92a5uwjf	278	25	positive	positive	JJ
cord-270337-92a5uwjf	278	26	inotropic	inotropic	JJ
cord-270337-92a5uwjf	278	27	effects	effect	NNS
cord-270337-92a5uwjf	278	28	of	of	IN
cord-270337-92a5uwjf	278	29	diazepam	diazepam	NN
cord-270337-92a5uwjf	278	30	under	under	IN
cord-270337-92a5uwjf	278	31	basal	basal	NN
cord-270337-92a5uwjf	278	32	conditions	condition	NNS
cord-270337-92a5uwjf	278	33	(	(	-LRB-
cord-270337-92a5uwjf	278	34	and	and	CC
cord-270337-92a5uwjf	278	35	negative	negative	JJ
cord-270337-92a5uwjf	278	36	inotropy	inotropy	NN
cord-270337-92a5uwjf	278	37	under	under	IN
cord-270337-92a5uwjf	278	38	certain	certain	JJ
cord-270337-92a5uwjf	278	39	conditions	condition	NNS
cord-270337-92a5uwjf	278	40	[	[	-LRB-
cord-270337-92a5uwjf	278	41	Zeegers	Zeegers	NNP
cord-270337-92a5uwjf	278	42	,	,	,
cord-270337-92a5uwjf	278	43	van	van	NNP
cord-270337-92a5uwjf	278	44	Wilgenburg	Wilgenburg	NNP
cord-270337-92a5uwjf	278	45	,	,	,
cord-270337-92a5uwjf	278	46	&	&	CC
cord-270337-92a5uwjf	278	47	Leeuwin	Leeuwin	NNP
cord-270337-92a5uwjf	278	48	,	,	,
cord-270337-92a5uwjf	278	49	1998	1998	CD
cord-270337-92a5uwjf	278	50	]	]	-RRB-
cord-270337-92a5uwjf	278	51	)	)	-RRB-
cord-270337-92a5uwjf	278	52	,	,	,
cord-270337-92a5uwjf	278	53	the	the	DT
cord-270337-92a5uwjf	278	54	use	use	NN
cord-270337-92a5uwjf	278	55	of	of	IN
cord-270337-92a5uwjf	278	56	a	a	DT
cord-270337-92a5uwjf	278	57	positive	positive	JJ
cord-270337-92a5uwjf	278	58	inotrope	inotrope	NN
cord-270337-92a5uwjf	278	59	seems	seem	VBZ
cord-270337-92a5uwjf	278	60	essential	essential	JJ
cord-270337-92a5uwjf	278	61	for	for	IN
cord-270337-92a5uwjf	278	62	the	the	DT
cord-270337-92a5uwjf	278	63	improvement	improvement	NN
cord-270337-92a5uwjf	278	64	in	in	IN
cord-270337-92a5uwjf	278	65	the	the	DT
cord-270337-92a5uwjf	278	66	cardiac	cardiac	JJ
cord-270337-92a5uwjf	278	67	function	function	NN
cord-270337-92a5uwjf	278	68	following	follow	VBG
cord-270337-92a5uwjf	278	69	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	278	70	toxicity	toxicity	NN
cord-270337-92a5uwjf	278	71	.	.	.
cord-270337-92a5uwjf	279	1	While	while	IN
cord-270337-92a5uwjf	279	2	neither	neither	CC
cord-270337-92a5uwjf	279	3	diazepam	diazepam	NN
cord-270337-92a5uwjf	279	4	nor	nor	CC
cord-270337-92a5uwjf	279	5	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	279	6	alone	alone	RB
cord-270337-92a5uwjf	279	7	reversed	reverse	VBD
cord-270337-92a5uwjf	279	8	any	any	DT
cord-270337-92a5uwjf	279	9	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	279	10	-	-	HYPH
cord-270337-92a5uwjf	279	11	induced	induce	VBN
cord-270337-92a5uwjf	279	12	cardiovascular	cardiovascular	JJ
cord-270337-92a5uwjf	279	13	changes	change	NNS
cord-270337-92a5uwjf	279	14	,	,	,
cord-270337-92a5uwjf	279	15	the	the	DT
cord-270337-92a5uwjf	279	16	improvement	improvement	NN
cord-270337-92a5uwjf	279	17	in	in	IN
cord-270337-92a5uwjf	279	18	cardiac	cardiac	JJ
cord-270337-92a5uwjf	279	19	contractility	contractility	NN
cord-270337-92a5uwjf	279	20	observed	observe	VBD
cord-270337-92a5uwjf	279	21	with	with	IN
cord-270337-92a5uwjf	279	22	their	-PRON-	PRP$
cord-270337-92a5uwjf	279	23	combined	combined	JJ
cord-270337-92a5uwjf	279	24	administration	administration	NN
cord-270337-92a5uwjf	279	25	may	may	MD
cord-270337-92a5uwjf	279	26	indicate	indicate	VB
cord-270337-92a5uwjf	279	27	a	a	DT
cord-270337-92a5uwjf	279	28	beneficial	beneficial	JJ
cord-270337-92a5uwjf	279	29	interaction	interaction	NN
cord-270337-92a5uwjf	279	30	.	.	.
cord-270337-92a5uwjf	280	1	Studies	study	NNS
cord-270337-92a5uwjf	280	2	in	in	IN
cord-270337-92a5uwjf	280	3	rat	rat	NN
cord-270337-92a5uwjf	280	4	ventricular	ventricular	JJ
cord-270337-92a5uwjf	280	5	tissues	tissue	NNS
cord-270337-92a5uwjf	280	6	demonstrated	demonstrate	VBD
cord-270337-92a5uwjf	280	7	that	that	IN
cord-270337-92a5uwjf	280	8	diazepam	diazepam	NN
cord-270337-92a5uwjf	280	9	(	(	-LRB-
cord-270337-92a5uwjf	280	10	10	10	CD
cord-270337-92a5uwjf	280	11	μM	μm	CD
cord-270337-92a5uwjf	280	12	)	)	-RRB-
cord-270337-92a5uwjf	280	13	augmented	augment	VBN
cord-270337-92a5uwjf	280	14	contractility	contractility	NN
cord-270337-92a5uwjf	280	15	due	due	IN
cord-270337-92a5uwjf	280	16	to	to	IN
cord-270337-92a5uwjf	280	17	isoprenaline	isoprenaline	NNP
cord-270337-92a5uwjf	280	18	(	(	-LRB-
cord-270337-92a5uwjf	280	19	Martinez	Martinez	NNP
cord-270337-92a5uwjf	280	20	,	,	,
cord-270337-92a5uwjf	280	21	Peñafiel	Peñafiel	NNP
cord-270337-92a5uwjf	280	22	,	,	,
cord-270337-92a5uwjf	280	23	Collado	Collado	NNP
cord-270337-92a5uwjf	280	24	,	,	,
cord-270337-92a5uwjf	280	25	&	&	CC
cord-270337-92a5uwjf	280	26	Hernández	Hernández	NNP
cord-270337-92a5uwjf	280	27	,	,	,
cord-270337-92a5uwjf	280	28	1995	1995	CD
cord-270337-92a5uwjf	280	29	)	)	-RRB-
cord-270337-92a5uwjf	280	30	,	,	,
cord-270337-92a5uwjf	280	31	noradrenaline	noradrenaline	NN
cord-270337-92a5uwjf	280	32	(	(	-LRB-
cord-270337-92a5uwjf	280	33	Juan	Juan	NNP
cord-270337-92a5uwjf	280	34	-	-	HYPH
cord-270337-92a5uwjf	280	35	Fita	Fita	NNP
cord-270337-92a5uwjf	280	36	,	,	,
cord-270337-92a5uwjf	280	37	Vargas	Vargas	NNP
cord-270337-92a5uwjf	280	38	,	,	,
cord-270337-92a5uwjf	280	39	&	&	CC
cord-270337-92a5uwjf	280	40	Hernández	Hernández	NNP
cord-270337-92a5uwjf	280	41	,	,	,
cord-270337-92a5uwjf	280	42	2003	2003	CD
cord-270337-92a5uwjf	280	43	)	)	-RRB-
cord-270337-92a5uwjf	280	44	and	and	CC
cord-270337-92a5uwjf	280	45	dopamine	dopamine	NN
cord-270337-92a5uwjf	280	46	(	(	-LRB-
cord-270337-92a5uwjf	280	47	Juan	Juan	NNP
cord-270337-92a5uwjf	280	48	-	-	HYPH
cord-270337-92a5uwjf	280	49	Fita	Fita	NNP
cord-270337-92a5uwjf	280	50	,	,	,
cord-270337-92a5uwjf	280	51	Vargas	Vargas	NNP
cord-270337-92a5uwjf	280	52	,	,	,
cord-270337-92a5uwjf	280	53	&	&	CC
cord-270337-92a5uwjf	280	54	Hernández	Hernández	NNP
cord-270337-92a5uwjf	280	55	,	,	,
cord-270337-92a5uwjf	280	56	2006	2006	CD
cord-270337-92a5uwjf	280	57	)	)	-RRB-
cord-270337-92a5uwjf	280	58	.	.	.
cord-270337-92a5uwjf	281	1	These	these	DT
cord-270337-92a5uwjf	281	2	effects	effect	NNS
cord-270337-92a5uwjf	281	3	were	be	VBD
cord-270337-92a5uwjf	281	4	not	not	RB
cord-270337-92a5uwjf	281	5	mimicked	mimic	VBN
cord-270337-92a5uwjf	281	6	by	by	IN
cord-270337-92a5uwjf	281	7	GABA	GABA	NNP
cord-270337-92a5uwjf	281	8	nor	nor	CC
cord-270337-92a5uwjf	281	9	antagonised	antagonise	VBN
cord-270337-92a5uwjf	281	10	by	by	IN
cord-270337-92a5uwjf	281	11	the	the	DT
cord-270337-92a5uwjf	281	12	selective	selective	JJ
cord-270337-92a5uwjf	281	13	TSPO	TSPO	NNP
cord-270337-92a5uwjf	281	14	inhibitor	inhibitor	NN
cord-270337-92a5uwjf	281	15	PK11195	pk11195	NN
cord-270337-92a5uwjf	281	16	or	or	CC
cord-270337-92a5uwjf	281	17	flumazenil	flumazenil	NN
cord-270337-92a5uwjf	281	18	,	,	,
cord-270337-92a5uwjf	281	19	an	an	DT
cord-270337-92a5uwjf	281	20	antagonist	antagonist	NN
cord-270337-92a5uwjf	281	21	of	of	IN
cord-270337-92a5uwjf	281	22	the	the	DT
cord-270337-92a5uwjf	281	23	GABA	GABA	NNP
cord-270337-92a5uwjf	281	24	A	a	DT
cord-270337-92a5uwjf	281	25	benzodiazepine	benzodiazepine	NN
cord-270337-92a5uwjf	281	26	binding	binding	NN
cord-270337-92a5uwjf	281	27	site	site	NN
cord-270337-92a5uwjf	281	28	.	.	.
cord-270337-92a5uwjf	282	1	Rather	rather	RB
cord-270337-92a5uwjf	282	2	,	,	,
cord-270337-92a5uwjf	282	3	they	-PRON-	PRP
cord-270337-92a5uwjf	282	4	were	be	VBD
cord-270337-92a5uwjf	282	5	attributed	attribute	VBN
cord-270337-92a5uwjf	282	6	to	to	IN
cord-270337-92a5uwjf	282	7	diazepam	diazepam	NN
cord-270337-92a5uwjf	282	8	's	's	POS
cord-270337-92a5uwjf	282	9	ability	ability	NN
cord-270337-92a5uwjf	282	10	to	to	TO
cord-270337-92a5uwjf	282	11	inhibit	inhibit	VB
cord-270337-92a5uwjf	282	12	PDE4	PDE4	NNP
cord-270337-92a5uwjf	282	13	,	,	,
cord-270337-92a5uwjf	282	14	the	the	DT
cord-270337-92a5uwjf	282	15	main	main	JJ
cord-270337-92a5uwjf	282	16	isoenzyme	isoenzyme	NNS
cord-270337-92a5uwjf	282	17	responsible	responsible	JJ
cord-270337-92a5uwjf	282	18	for	for	IN
cord-270337-92a5uwjf	282	19	the	the	DT
cord-270337-92a5uwjf	282	20	inotropic	inotropic	NNP
cord-270337-92a5uwjf	282	21	effect	effect	NN
cord-270337-92a5uwjf	282	22	of	of	IN
cord-270337-92a5uwjf	282	23	β	β	NN
cord-270337-92a5uwjf	282	24	-	-	HYPH
cord-270337-92a5uwjf	282	25	adrenoceptor	adrenoceptor	NNP
cord-270337-92a5uwjf	282	26	agonists	agonist	NNS
cord-270337-92a5uwjf	282	27	in	in	IN
cord-270337-92a5uwjf	282	28	the	the	DT
cord-270337-92a5uwjf	282	29	rat	rat	NN
cord-270337-92a5uwjf	282	30	myocardium	myocardium	NN
cord-270337-92a5uwjf	282	31	.	.	.
cord-270337-92a5uwjf	283	1	This	this	DT
cord-270337-92a5uwjf	283	2	offers	offer	VBZ
cord-270337-92a5uwjf	283	3	a	a	DT
cord-270337-92a5uwjf	283	4	plausible	plausible	JJ
cord-270337-92a5uwjf	283	5	mechanism	mechanism	NN
cord-270337-92a5uwjf	283	6	for	for	IN
cord-270337-92a5uwjf	283	7	the	the	DT
cord-270337-92a5uwjf	283	8	observed	observed	JJ
cord-270337-92a5uwjf	283	9	effects	effect	NNS
cord-270337-92a5uwjf	283	10	in	in	IN
cord-270337-92a5uwjf	283	11	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	283	12	-	-	HYPH
cord-270337-92a5uwjf	283	13	intoxicated	intoxicate	VBN
cord-270337-92a5uwjf	283	14	rats	rat	NNS
cord-270337-92a5uwjf	283	15	.	.	.
cord-270337-92a5uwjf	284	1	However	however	RB
cord-270337-92a5uwjf	284	2	,	,	,
cord-270337-92a5uwjf	284	3	there	there	EX
cord-270337-92a5uwjf	284	4	are	be	VBP
cord-270337-92a5uwjf	284	5	differences	difference	NNS
cord-270337-92a5uwjf	284	6	between	between	IN
cord-270337-92a5uwjf	284	7	species	specie	NNS
cord-270337-92a5uwjf	284	8	in	in	IN
cord-270337-92a5uwjf	284	9	the	the	DT
cord-270337-92a5uwjf	284	10	expression	expression	NN
cord-270337-92a5uwjf	284	11	of	of	IN
cord-270337-92a5uwjf	284	12	PDE4	PDE4	NNP
cord-270337-92a5uwjf	284	13	,	,	,
cord-270337-92a5uwjf	284	14	with	with	IN
cord-270337-92a5uwjf	284	15	a	a	DT
cord-270337-92a5uwjf	284	16	fivefold	fivefold	JJ
cord-270337-92a5uwjf	284	17	higher	high	JJR
cord-270337-92a5uwjf	284	18	amount	amount	NN
cord-270337-92a5uwjf	284	19	of	of	IN
cord-270337-92a5uwjf	284	20	non	non	JJ
cord-270337-92a5uwjf	284	21	-	-	JJ
cord-270337-92a5uwjf	284	22	PDE4	pde4	JJ
cord-270337-92a5uwjf	284	23	activity	activity	NN
cord-270337-92a5uwjf	284	24	in	in	IN
cord-270337-92a5uwjf	284	25	human	human	JJ
cord-270337-92a5uwjf	284	26	hearts	heart	NNS
cord-270337-92a5uwjf	284	27	compared	compare	VBN
cord-270337-92a5uwjf	284	28	to	to	IN
cord-270337-92a5uwjf	284	29	rodents	rodent	NNS
cord-270337-92a5uwjf	284	30	,	,	,
cord-270337-92a5uwjf	284	31	and	and	CC
cord-270337-92a5uwjf	284	32	this	this	DT
cord-270337-92a5uwjf	284	33	will	will	MD
cord-270337-92a5uwjf	284	34	impact	impact	VB
cord-270337-92a5uwjf	284	35	on	on	IN
cord-270337-92a5uwjf	284	36	the	the	DT
cord-270337-92a5uwjf	284	37	effect	effect	NN
cord-270337-92a5uwjf	284	38	of	of	IN
cord-270337-92a5uwjf	284	39	enzyme	enzyme	NN
cord-270337-92a5uwjf	284	40	inhibition	inhibition	NN
cord-270337-92a5uwjf	284	41	(	(	-LRB-
cord-270337-92a5uwjf	284	42	Richter	Richter	NNP
cord-270337-92a5uwjf	284	43	et	et	NNP
cord-270337-92a5uwjf	284	44	al	al	NNP
cord-270337-92a5uwjf	284	45	.	.	NNP
cord-270337-92a5uwjf	284	46	,	,	,
cord-270337-92a5uwjf	284	47	2011	2011	CD
cord-270337-92a5uwjf	284	48	)	)	-RRB-
cord-270337-92a5uwjf	284	49	.	.	.
cord-270337-92a5uwjf	285	1	Further	further	JJ
cord-270337-92a5uwjf	285	2	mechanistic	mechanistic	JJ
cord-270337-92a5uwjf	285	3	studies	study	NNS
cord-270337-92a5uwjf	285	4	are	be	VBP
cord-270337-92a5uwjf	285	5	warranted	warrant	VBN
cord-270337-92a5uwjf	285	6	to	to	TO
cord-270337-92a5uwjf	285	7	assess	assess	VB
cord-270337-92a5uwjf	285	8	the	the	DT
cord-270337-92a5uwjf	285	9	role	role	NN
cord-270337-92a5uwjf	285	10	of	of	IN
cord-270337-92a5uwjf	285	11	PDE4	PDE4	NNP
cord-270337-92a5uwjf	285	12	inhibition	inhibition	NN
cord-270337-92a5uwjf	285	13	in	in	IN
cord-270337-92a5uwjf	285	14	this	this	DT
cord-270337-92a5uwjf	285	15	context	context	NN
cord-270337-92a5uwjf	285	16	.	.	.
cord-270337-92a5uwjf	286	1	In	in	IN
cord-270337-92a5uwjf	286	2	conclusion	conclusion	NN
cord-270337-92a5uwjf	286	3	,	,	,
cord-270337-92a5uwjf	286	4	the	the	DT
cord-270337-92a5uwjf	286	5	results	result	NNS
cord-270337-92a5uwjf	286	6	of	of	IN
cord-270337-92a5uwjf	286	7	this	this	DT
cord-270337-92a5uwjf	286	8	study	study	NN
cord-270337-92a5uwjf	286	9	do	do	VBP
cord-270337-92a5uwjf	286	10	not	not	RB
cord-270337-92a5uwjf	286	11	offer	offer	VB
cord-270337-92a5uwjf	286	12	compelling	compelling	JJ
cord-270337-92a5uwjf	286	13	support	support	NN
cord-270337-92a5uwjf	286	14	for	for	IN
cord-270337-92a5uwjf	286	15	the	the	DT
cord-270337-92a5uwjf	286	16	use	use	NN
cord-270337-92a5uwjf	286	17	of	of	IN
cord-270337-92a5uwjf	286	18	diazepam	diazepam	NN
cord-270337-92a5uwjf	286	19	in	in	IN
cord-270337-92a5uwjf	286	20	reducing	reduce	VBG
cord-270337-92a5uwjf	286	21	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	286	22	cardiotoxicity	cardiotoxicity	NN
cord-270337-92a5uwjf	286	23	.	.	.
cord-270337-92a5uwjf	287	1	Ligands	Ligands	NNP
cord-270337-92a5uwjf	287	2	for	for	IN
cord-270337-92a5uwjf	287	3	benzodiazepine	benzodiazepine	NN
cord-270337-92a5uwjf	287	4	binding	binding	NN
cord-270337-92a5uwjf	287	5	site	site	NN
cord-270337-92a5uwjf	287	6	,	,	,
cord-270337-92a5uwjf	287	7	clonazepam	clonazepam	NN
cord-270337-92a5uwjf	287	8	,	,	,
cord-270337-92a5uwjf	287	9	and	and	CC
cord-270337-92a5uwjf	287	10	Ro5	ro5	CD
cord-270337-92a5uwjf	287	11	-	-	HYPH
cord-270337-92a5uwjf	287	12	4864	4864	CD
cord-270337-92a5uwjf	287	13	were	be	VBD
cord-270337-92a5uwjf	287	14	similarly	similarly	RB
cord-270337-92a5uwjf	287	15	ineffective	ineffective	JJ
cord-270337-92a5uwjf	287	16	in	in	IN
cord-270337-92a5uwjf	287	17	the	the	DT
cord-270337-92a5uwjf	287	18	experimental	experimental	JJ
cord-270337-92a5uwjf	287	19	models	model	NNS
cord-270337-92a5uwjf	287	20	used	use	VBN
cord-270337-92a5uwjf	287	21	.	.	.
cord-270337-92a5uwjf	288	1	However	however	RB
cord-270337-92a5uwjf	288	2	,	,	,
cord-270337-92a5uwjf	288	3	the	the	DT
cord-270337-92a5uwjf	288	4	results	result	NNS
cord-270337-92a5uwjf	288	5	provide	provide	VBP
cord-270337-92a5uwjf	288	6	evidence	evidence	NN
cord-270337-92a5uwjf	288	7	that	that	IN
cord-270337-92a5uwjf	288	8	diazepam	diazepam	NN
cord-270337-92a5uwjf	288	9	might	may	MD
cord-270337-92a5uwjf	288	10	enhance	enhance	VB
cord-270337-92a5uwjf	288	11	cardiac	cardiac	JJ
cord-270337-92a5uwjf	288	12	contractility	contractility	NN
cord-270337-92a5uwjf	288	13	when	when	WRB
cord-270337-92a5uwjf	288	14	co	co	NN
cord-270337-92a5uwjf	288	15	-	-	VBN
cord-270337-92a5uwjf	288	16	administered	administer	VBN
cord-270337-92a5uwjf	288	17	with	with	IN
cord-270337-92a5uwjf	288	18	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	288	19	,	,	,
cord-270337-92a5uwjf	288	20	although	although	IN
cord-270337-92a5uwjf	288	21	the	the	DT
cord-270337-92a5uwjf	288	22	lowering	lowering	NN
cord-270337-92a5uwjf	288	23	of	of	IN
cord-270337-92a5uwjf	288	24	whole	whole	JJ
cord-270337-92a5uwjf	288	25	blood	blood	NN
cord-270337-92a5uwjf	288	26	potassium	potassium	NN
cord-270337-92a5uwjf	288	27	concentrations	concentration	NNS
cord-270337-92a5uwjf	288	28	,	,	,
cord-270337-92a5uwjf	288	29	consistent	consistent	JJ
cord-270337-92a5uwjf	288	30	with	with	IN
cord-270337-92a5uwjf	288	31	agonism	agonism	NN
cord-270337-92a5uwjf	288	32	of	of	IN
cord-270337-92a5uwjf	288	33	β	β	NN
cord-270337-92a5uwjf	288	34	2	2	CD
cord-270337-92a5uwjf	288	35	-adrenoceptors	-adrenoceptor	NNS
cord-270337-92a5uwjf	288	36	in	in	IN
cord-270337-92a5uwjf	288	37	skeletal	skeletal	JJ
cord-270337-92a5uwjf	288	38	muscle	muscle	NN
cord-270337-92a5uwjf	288	39	,	,	,
cord-270337-92a5uwjf	288	40	might	may	MD
cord-270337-92a5uwjf	288	41	risk	risk	VB
cord-270337-92a5uwjf	288	42	exacerbation	exacerbation	NN
cord-270337-92a5uwjf	288	43	of	of	IN
cord-270337-92a5uwjf	288	44	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	288	45	-	-	HYPH
cord-270337-92a5uwjf	288	46	induced	induce	VBN
cord-270337-92a5uwjf	288	47	hypokalaemia	hypokalaemia	NN
cord-270337-92a5uwjf	289	1	(	(	-LRB-
cord-270337-92a5uwjf	289	2	Clemessy	Clemessy	NNP
cord-270337-92a5uwjf	289	3	et	et	FW
cord-270337-92a5uwjf	289	4	al	al	NNP
cord-270337-92a5uwjf	289	5	.	.	NNP
cord-270337-92a5uwjf	289	6	,	,	,
cord-270337-92a5uwjf	289	7	1995	1995	CD
cord-270337-92a5uwjf	289	8	)	)	-RRB-
cord-270337-92a5uwjf	289	9	and	and	CC
cord-270337-92a5uwjf	289	10	increased	increase	VBN
cord-270337-92a5uwjf	289	11	arrhythmogenicity	arrhythmogenicity	NN
cord-270337-92a5uwjf	289	12	.	.	.
cord-270337-92a5uwjf	290	1	These	these	DT
cord-270337-92a5uwjf	290	2	new	new	JJ
cord-270337-92a5uwjf	290	3	insights	insight	NNS
cord-270337-92a5uwjf	290	4	have	have	VBP
cord-270337-92a5uwjf	290	5	important	important	JJ
cord-270337-92a5uwjf	290	6	clinical	clinical	JJ
cord-270337-92a5uwjf	290	7	and	and	CC
cord-270337-92a5uwjf	290	8	research	research	NN
cord-270337-92a5uwjf	290	9	implications	implication	NNS
cord-270337-92a5uwjf	290	10	in	in	IN
cord-270337-92a5uwjf	290	11	the	the	DT
cord-270337-92a5uwjf	290	12	current	current	JJ
cord-270337-92a5uwjf	290	13	context	context	NN
cord-270337-92a5uwjf	290	14	of	of	IN
cord-270337-92a5uwjf	290	15	widespread	widespread	JJ
cord-270337-92a5uwjf	290	16	publicity	publicity	NN
cord-270337-92a5uwjf	290	17	and	and	CC
cord-270337-92a5uwjf	290	18	use	use	NN
cord-270337-92a5uwjf	290	19	of	of	IN
cord-270337-92a5uwjf	290	20	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	290	21	for	for	IN
cord-270337-92a5uwjf	290	22	COVID-19	COVID-19	NNP
cord-270337-92a5uwjf	290	23	.	.	.
cord-270337-92a5uwjf	291	1	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	291	2	is	be	VBZ
cord-270337-92a5uwjf	291	3	widely	widely	RB
cord-270337-92a5uwjf	291	4	used	use	VBN
cord-270337-92a5uwjf	291	5	and	and	CC
cord-270337-92a5uwjf	291	6	available	available	JJ
cord-270337-92a5uwjf	291	7	without	without	IN
cord-270337-92a5uwjf	291	8	prescription	prescription	NN
cord-270337-92a5uwjf	291	9	in	in	IN
cord-270337-92a5uwjf	291	10	many	many	JJ
cord-270337-92a5uwjf	291	11	countries	country	NNS
cord-270337-92a5uwjf	291	12	,	,	,
cord-270337-92a5uwjf	291	13	including	include	VBG
cord-270337-92a5uwjf	291	14	the	the	DT
cord-270337-92a5uwjf	291	15	United	United	NNP
cord-270337-92a5uwjf	291	16	Kingdom	Kingdom	NNP
cord-270337-92a5uwjf	291	17	,	,	,
cord-270337-92a5uwjf	291	18	presenting	present	VBG
cord-270337-92a5uwjf	291	19	dangerous	dangerous	JJ
cord-270337-92a5uwjf	291	20	opportunities	opportunity	NNS
cord-270337-92a5uwjf	291	21	for	for	IN
cord-270337-92a5uwjf	291	22	unintentional	unintentional	JJ
cord-270337-92a5uwjf	291	23	overdose	overdose	NN
cord-270337-92a5uwjf	291	24	.	.	.
cord-270337-92a5uwjf	292	1	For	for	IN
cord-270337-92a5uwjf	292	2	the	the	DT
cord-270337-92a5uwjf	292	3	management	management	NN
cord-270337-92a5uwjf	292	4	of	of	IN
cord-270337-92a5uwjf	292	5	patients	patient	NNS
cord-270337-92a5uwjf	292	6	with	with	IN
cord-270337-92a5uwjf	292	7	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	292	8	poisoning	poisoning	NN
cord-270337-92a5uwjf	292	9	,	,	,
cord-270337-92a5uwjf	292	10	testing	test	VBG
cord-270337-92a5uwjf	292	11	the	the	DT
cord-270337-92a5uwjf	292	12	efficacy	efficacy	NN
cord-270337-92a5uwjf	292	13	of	of	IN
cord-270337-92a5uwjf	292	14	a	a	DT
cord-270337-92a5uwjf	292	15	positive	positive	JJ
cord-270337-92a5uwjf	292	16	inotrope	inotrope	NN
cord-270337-92a5uwjf	292	17	with	with	IN
cord-270337-92a5uwjf	292	18	a	a	DT
cord-270337-92a5uwjf	292	19	greater	great	JJR
cord-270337-92a5uwjf	292	20	selectivity	selectivity	NN
cord-270337-92a5uwjf	292	21	for	for	IN
cord-270337-92a5uwjf	292	22	β	β	NN
cord-270337-92a5uwjf	293	1	1adrenoceptors	1adrenoceptors	CD
cord-270337-92a5uwjf	293	2	,	,	,
cord-270337-92a5uwjf	293	3	such	such	JJ
cord-270337-92a5uwjf	293	4	as	as	IN
cord-270337-92a5uwjf	293	5	dobutamine	dobutamine	NN
cord-270337-92a5uwjf	293	6	,	,	,
cord-270337-92a5uwjf	293	7	would	would	MD
cord-270337-92a5uwjf	293	8	be	be	VB
cord-270337-92a5uwjf	293	9	desirable	desirable	JJ
cord-270337-92a5uwjf	293	10	,	,	,
cord-270337-92a5uwjf	293	11	as	as	IN
cord-270337-92a5uwjf	293	12	would	would	MD
cord-270337-92a5uwjf	293	13	a	a	DT
cord-270337-92a5uwjf	293	14	greater	great	JJR
cord-270337-92a5uwjf	293	15	understanding	understanding	NN
cord-270337-92a5uwjf	293	16	of	of	IN
cord-270337-92a5uwjf	293	17	the	the	DT
cord-270337-92a5uwjf	293	18	non	non	JJ
cord-270337-92a5uwjf	293	19	-	-	JJ
cord-270337-92a5uwjf	293	20	cardiovascular	cardiovascular	JJ
cord-270337-92a5uwjf	293	21	roles	role	NNS
cord-270337-92a5uwjf	293	22	for	for	IN
cord-270337-92a5uwjf	293	23	diazepam	diazepam	NN
cord-270337-92a5uwjf	293	24	treatment	treatment	NN
cord-270337-92a5uwjf	293	25	given	give	VBN
cord-270337-92a5uwjf	293	26	that	that	IN
cord-270337-92a5uwjf	293	27	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	293	28	poisoning	poisoning	NN
cord-270337-92a5uwjf	293	29	often	often	RB
cord-270337-92a5uwjf	293	30	causes	cause	VBZ
cord-270337-92a5uwjf	293	31	convulsions	convulsion	NNS
cord-270337-92a5uwjf	293	32	,	,	,
cord-270337-92a5uwjf	293	33	which	which	WDT
cord-270337-92a5uwjf	293	34	can	can	MD
cord-270337-92a5uwjf	293	35	be	be	VB
cord-270337-92a5uwjf	293	36	intractable	intractable	JJ
cord-270337-92a5uwjf	293	37	.	.	.
cord-270337-92a5uwjf	294	1	Press	press	NN
cord-270337-92a5uwjf	294	2	release	release	NN
cord-270337-92a5uwjf	294	3	-	-	:
cord-270337-92a5uwjf	294	4	Coronavirus	Coronavirus	NNP
cord-270337-92a5uwjf	294	5	:	:	:
cord-270337-92a5uwjf	295	1	Situation	situation	NN
cord-270337-92a5uwjf	295	2	point	point	NN
cord-270337-92a5uwjf	295	3	in	in	IN
cord-270337-92a5uwjf	295	4	New	New	NNP
cord-270337-92a5uwjf	295	5	Aquitaine	Aquitaine	NNP
cord-270337-92a5uwjf	296	1	The	the	DT
cord-270337-92a5uwjf	296	2	Concise	Concise	NNP
cord-270337-92a5uwjf	296	3	Guide	Guide	NNP
cord-270337-92a5uwjf	296	4	to	to	IN
cord-270337-92a5uwjf	296	5	PHAR	PHAR	NNP
cord-270337-92a5uwjf	296	6	-	-	HYPH
cord-270337-92a5uwjf	296	7	MACOLOGY	MACOLOGY	NNP
cord-270337-92a5uwjf	296	8	2019/20	2019/20	CD
cord-270337-92a5uwjf	296	9	:	:	:
cord-270337-92a5uwjf	297	1	Ion	ion	NN
cord-270337-92a5uwjf	297	2	channels	channel	NNS
cord-270337-92a5uwjf	298	1	An	an	DT
cord-270337-92a5uwjf	298	2	analysis	analysis	NN
cord-270337-92a5uwjf	298	3	of	of	IN
cord-270337-92a5uwjf	298	4	the	the	DT
cord-270337-92a5uwjf	298	5	time	time	NN
cord-270337-92a5uwjf	298	6	-	-	HYPH
cord-270337-92a5uwjf	298	7	relations	relation	NNS
cord-270337-92a5uwjf	298	8	of	of	IN
cord-270337-92a5uwjf	298	9	electrocardiograms	electrocardiogram	NNS
cord-270337-92a5uwjf	298	10	Coronavirus	Coronavirus	NNP
cord-270337-92a5uwjf	299	1	:	:	:
cord-270337-92a5uwjf	299	2	Man	man	NN
cord-270337-92a5uwjf	299	3	dies	die	VBZ
cord-270337-92a5uwjf	299	4	after	after	IN
cord-270337-92a5uwjf	299	5	ingesting	ingest	VBG
cord-270337-92a5uwjf	299	6	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	299	7	in	in	IN
cord-270337-92a5uwjf	299	8	attempt	attempt	NN
cord-270337-92a5uwjf	299	9	to	to	TO
cord-270337-92a5uwjf	299	10	ward	ward	VB
cord-270337-92a5uwjf	299	11	off	off	RP
cord-270337-92a5uwjf	299	12	COVID-19	COVID-19	NNP
cord-270337-92a5uwjf	299	13	.	.	.
cord-270337-92a5uwjf	300	1	Sky	Sky	NNP
cord-270337-92a5uwjf	300	2	News	News	NNP
cord-270337-92a5uwjf	300	3	Effect	Effect	NNP
cord-270337-92a5uwjf	300	4	of	of	IN
cord-270337-92a5uwjf	300	5	high	high	JJ
cord-270337-92a5uwjf	300	6	vs	vs	IN
cord-270337-92a5uwjf	300	7	low	low	JJ
cord-270337-92a5uwjf	300	8	doses	dose	NNS
cord-270337-92a5uwjf	300	9	of	of	IN
cord-270337-92a5uwjf	300	10	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	300	11	diphosphate	diphosphate	NN
cord-270337-92a5uwjf	300	12	as	as	IN
cord-270337-92a5uwjf	300	13	adjunctive	adjunctive	JJ
cord-270337-92a5uwjf	300	14	therapy	therapy	NN
cord-270337-92a5uwjf	300	15	for	for	IN
cord-270337-92a5uwjf	300	16	patients	patient	NNS
cord-270337-92a5uwjf	300	17	hospitalized	hospitalize	VBN
cord-270337-92a5uwjf	300	18	with	with	IN
cord-270337-92a5uwjf	300	19	severe	severe	JJ
cord-270337-92a5uwjf	300	20	acute	acute	JJ
cord-270337-92a5uwjf	300	21	respiratory	respiratory	JJ
cord-270337-92a5uwjf	300	22	syndrome	syndrome	NN
cord-270337-92a5uwjf	300	23	coronavirus	coronavirus	NN
cord-270337-92a5uwjf	300	24	2	2	CD
cord-270337-92a5uwjf	301	1	(	(	-LRB-
cord-270337-92a5uwjf	301	2	SARS	SARS	NNP
cord-270337-92a5uwjf	301	3	-	-	HYPH
cord-270337-92a5uwjf	301	4	CoV-2	CoV-2	NNP
cord-270337-92a5uwjf	301	5	)	)	-RRB-
cord-270337-92a5uwjf	301	6	infection	infection	NN
cord-270337-92a5uwjf	301	7	:	:	:
cord-270337-92a5uwjf	301	8	A	a	DT
cord-270337-92a5uwjf	301	9	randomized	randomized	JJ
cord-270337-92a5uwjf	301	10	clinical	clinical	JJ
cord-270337-92a5uwjf	301	11	trial	trial	NN
cord-270337-92a5uwjf	301	12	Effects	effect	NNS
cord-270337-92a5uwjf	301	13	of	of	IN
cord-270337-92a5uwjf	301	14	catecholamines	catecholamine	NNS
cord-270337-92a5uwjf	301	15	and	and	CC
cord-270337-92a5uwjf	301	16	diazepam	diazepam	NN
cord-270337-92a5uwjf	301	17	in	in	IN
cord-270337-92a5uwjf	301	18	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	301	19	poisoning	poisoning	NN
cord-270337-92a5uwjf	301	20	in	in	IN
cord-270337-92a5uwjf	301	21	barbiturate	barbiturate	NN
cord-270337-92a5uwjf	301	22	anaesthetised	anaesthetise	VBN
cord-270337-92a5uwjf	301	23	rats	rat	NNS
cord-270337-92a5uwjf	301	24	Compendium	Compendium	NNP
cord-270337-92a5uwjf	301	25	of	of	IN
cord-270337-92a5uwjf	301	26	normal	normal	JJ
cord-270337-92a5uwjf	301	27	blood	blood	NN
cord-270337-92a5uwjf	301	28	values	value	NNS
cord-270337-92a5uwjf	301	29	of	of	IN
cord-270337-92a5uwjf	301	30	laboratory	laboratory	NN
cord-270337-92a5uwjf	301	31	animals	animal	NNS
cord-270337-92a5uwjf	301	32	with	with	IN
cord-270337-92a5uwjf	301	33	indication	indication	NN
cord-270337-92a5uwjf	301	34	of	of	IN
cord-270337-92a5uwjf	301	35	variations	variation	NNS
cord-270337-92a5uwjf	301	36	.	.	.
cord-270337-92a5uwjf	302	1	I.	I.	NNP
cord-270337-92a5uwjf	302	2	Random	random	JJ
cord-270337-92a5uwjf	302	3	-	-	HYPH
cord-270337-92a5uwjf	302	4	sexed	sexed	JJ
cord-270337-92a5uwjf	302	5	populations	population	NNS
cord-270337-92a5uwjf	302	6	of	of	IN
cord-270337-92a5uwjf	302	7	small	small	JJ
cord-270337-92a5uwjf	302	8	animals	animal	NNS
cord-270337-92a5uwjf	303	1	Nigeria	Nigeria	NNP
cord-270337-92a5uwjf	303	2	records	record	VBZ
cord-270337-92a5uwjf	303	3	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	303	4	poisoning	poisoning	NN
cord-270337-92a5uwjf	303	5	after	after	IN
cord-270337-92a5uwjf	303	6	Trump	Trump	NNP
cord-270337-92a5uwjf	303	7	endorses	endorse	VBZ
cord-270337-92a5uwjf	303	8	it	-PRON-	PRP
cord-270337-92a5uwjf	303	9	for	for	IN
cord-270337-92a5uwjf	303	10	coronavirus	coronavirus	NN
cord-270337-92a5uwjf	303	11	treatment	treatment	NN
cord-270337-92a5uwjf	303	12	Therapeutic	therapeutic	JJ
cord-270337-92a5uwjf	303	13	trial	trial	NN
cord-270337-92a5uwjf	303	14	of	of	IN
cord-270337-92a5uwjf	303	15	diazepam	diazepam	NN
cord-270337-92a5uwjf	303	16	versus	versus	IN
cord-270337-92a5uwjf	303	17	placebo	placebo	NN
cord-270337-92a5uwjf	303	18	in	in	IN
cord-270337-92a5uwjf	303	19	acute	acute	JJ
cord-270337-92a5uwjf	303	20	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	303	21	intoxications	intoxication	NNS
cord-270337-92a5uwjf	303	22	of	of	IN
cord-270337-92a5uwjf	303	23	moderate	moderate	JJ
cord-270337-92a5uwjf	303	24	gravity	gravity	NN
cord-270337-92a5uwjf	303	25	Hypokalaemia	Hypokalaemia	NNP
cord-270337-92a5uwjf	303	26	related	relate	VBN
cord-270337-92a5uwjf	303	27	to	to	IN
cord-270337-92a5uwjf	303	28	acute	acute	JJ
cord-270337-92a5uwjf	303	29	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	303	30	ingestion	ingestion	NN
cord-270337-92a5uwjf	303	31	Effects	effect	NNS
cord-270337-92a5uwjf	303	32	of	of	IN
cord-270337-92a5uwjf	303	33	mefloquine	mefloquine	NN
cord-270337-92a5uwjf	303	34	on	on	IN
cord-270337-92a5uwjf	303	35	cardiac	cardiac	JJ
cord-270337-92a5uwjf	303	36	contractility	contractility	NN
cord-270337-92a5uwjf	303	37	and	and	CC
cord-270337-92a5uwjf	303	38	electrical	electrical	JJ
cord-270337-92a5uwjf	303	39	activity	activity	NN
cord-270337-92a5uwjf	303	40	in	in	IN
cord-270337-92a5uwjf	303	41	vivo	vivo	NN
cord-270337-92a5uwjf	303	42	,	,	,
cord-270337-92a5uwjf	303	43	in	in	IN
cord-270337-92a5uwjf	303	44	isolated	isolate	VBN
cord-270337-92a5uwjf	303	45	cardiac	cardiac	JJ
cord-270337-92a5uwjf	303	46	preparations	preparation	NNS
cord-270337-92a5uwjf	303	47	,	,	,
cord-270337-92a5uwjf	303	48	and	and	CC
cord-270337-92a5uwjf	304	1	in	in	IN
cord-270337-92a5uwjf	304	2	single	single	JJ
cord-270337-92a5uwjf	304	3	ventricular	ventricular	JJ
cord-270337-92a5uwjf	304	4	myocytes	myocyte	NNS
cord-270337-92a5uwjf	304	5	Functional	functional	JJ
cord-270337-92a5uwjf	304	6	and	and	CC
cord-270337-92a5uwjf	304	7	biochemical	biochemical	JJ
cord-270337-92a5uwjf	304	8	evidence	evidence	NN
cord-270337-92a5uwjf	304	9	for	for	IN
cord-270337-92a5uwjf	304	10	diazepam	diazepam	NN
cord-270337-92a5uwjf	304	11	as	as	IN
cord-270337-92a5uwjf	304	12	a	a	DT
cord-270337-92a5uwjf	304	13	cyclic	cyclic	JJ
cord-270337-92a5uwjf	304	14	nucleotide	nucleotide	JJ
cord-270337-92a5uwjf	304	15	phosphodiesterase	phosphodiesterase	NN
cord-270337-92a5uwjf	304	16	type	type	NN
cord-270337-92a5uwjf	304	17	4	4	CD
cord-270337-92a5uwjf	304	18	inhibitor	inhibitor	NN
cord-270337-92a5uwjf	304	19	Experimental	experimental	JJ
cord-270337-92a5uwjf	304	20	assessment	assessment	NN
cord-270337-92a5uwjf	304	21	of	of	IN
cord-270337-92a5uwjf	304	22	the	the	DT
cord-270337-92a5uwjf	304	23	protective	protective	JJ
cord-270337-92a5uwjf	304	24	activity	activity	NN
cord-270337-92a5uwjf	304	25	of	of	IN
cord-270337-92a5uwjf	304	26	diazepam	diazepam	NN
cord-270337-92a5uwjf	304	27	on	on	IN
cord-270337-92a5uwjf	304	28	the	the	DT
cord-270337-92a5uwjf	304	29	acute	acute	JJ
cord-270337-92a5uwjf	304	30	toxicity	toxicity	NN
cord-270337-92a5uwjf	304	31	of	of	IN
cord-270337-92a5uwjf	304	32	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	304	33	Experimental	experimental	JJ
cord-270337-92a5uwjf	304	34	design	design	NN
cord-270337-92a5uwjf	304	35	and	and	CC
cord-270337-92a5uwjf	304	36	analysis	analysis	NN
cord-270337-92a5uwjf	304	37	and	and	CC
cord-270337-92a5uwjf	304	38	their	-PRON-	PRP$
cord-270337-92a5uwjf	304	39	reporting	reporting	NN
cord-270337-92a5uwjf	304	40	II	ii	CD
cord-270337-92a5uwjf	304	41	:	:	:
cord-270337-92a5uwjf	304	42	Updated	update	VBN
cord-270337-92a5uwjf	304	43	and	and	CC
cord-270337-92a5uwjf	304	44	simplified	simplified	JJ
cord-270337-92a5uwjf	304	45	guidance	guidance	NN
cord-270337-92a5uwjf	304	46	for	for	IN
cord-270337-92a5uwjf	304	47	authors	author	NNS
cord-270337-92a5uwjf	304	48	and	and	CC
cord-270337-92a5uwjf	304	49	peer	peer	NN
cord-270337-92a5uwjf	304	50	reviewers	reviewer	NNS
cord-270337-92a5uwjf	304	51	Effects	effect	NNS
cord-270337-92a5uwjf	304	52	of	of	IN
cord-270337-92a5uwjf	304	53	diazepam	diazepam	NN
cord-270337-92a5uwjf	304	54	on	on	IN
cord-270337-92a5uwjf	304	55	mortality	mortality	NN
cord-270337-92a5uwjf	304	56	from	from	IN
cord-270337-92a5uwjf	304	57	acute	acute	JJ
cord-270337-92a5uwjf	304	58	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	304	59	poisoning	poisoning	NN
cord-270337-92a5uwjf	304	60	.	.	.
cord-270337-92a5uwjf	305	1	Annales	Annales	NNP
cord-270337-92a5uwjf	305	2	Françaises	Françaises	NNPS
cord-270337-92a5uwjf	305	3	d'Anesthèsie	d'Anesthèsie	NNP
cord-270337-92a5uwjf	305	4	et	et	FW
cord-270337-92a5uwjf	305	5	de	de	FW
cord-270337-92a5uwjf	305	6	Rèanimation	Rèanimation	NNP
cord-270337-92a5uwjf	305	7	Intoxications	Intoxications	NNP
cord-270337-92a5uwjf	305	8	volontaires	volontaires	NNP
cord-270337-92a5uwjf	305	9	par	par	IN
cord-270337-92a5uwjf	305	10	la	la	FW
cord-270337-92a5uwjf	305	11	chloroquine	chloroquine	JJ
cord-270337-92a5uwjf	305	12	Effects	effect	NNS
cord-270337-92a5uwjf	305	13	of	of	IN
cord-270337-92a5uwjf	305	14	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	305	15	and	and	CC
cord-270337-92a5uwjf	305	16	didesethylchloroquine	didesethylchloroquine	NN
cord-270337-92a5uwjf	305	17	on	on	IN
cord-270337-92a5uwjf	305	18	rabbit	rabbit	NN
cord-270337-92a5uwjf	305	19	myocardium	myocardium	NN
cord-270337-92a5uwjf	305	20	and	and	CC
cord-270337-92a5uwjf	305	21	mitochondria	mitochondrion	NNS
cord-270337-92a5uwjf	305	22	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	305	23	and	and	CC
cord-270337-92a5uwjf	305	24	hydroxychloroquine	hydroxychloroquine	NN
cord-270337-92a5uwjf	305	25	in	in	IN
cord-270337-92a5uwjf	305	26	covid-19	covid-19	NNP
cord-270337-92a5uwjf	305	27	Request	Request	NNP
cord-270337-92a5uwjf	305	28	for	for	IN
cord-270337-92a5uwjf	305	29	emergency	emergency	NN
cord-270337-92a5uwjf	305	30	use	use	NN
cord-270337-92a5uwjf	305	31	authorization	authorization	NN
cord-270337-92a5uwjf	305	32	for	for	IN
cord-270337-92a5uwjf	305	33	use	use	NN
cord-270337-92a5uwjf	305	34	of	of	IN
cord-270337-92a5uwjf	305	35	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	305	36	phosphate	phosphate	NN
cord-270337-92a5uwjf	305	37	or	or	CC
cord-270337-92a5uwjf	305	38	hydroxychloroquine	hydroxychloroquine	NN
cord-270337-92a5uwjf	305	39	sulfate	sulfate	NN
cord-270337-92a5uwjf	305	40	supplied	supply	VBN
cord-270337-92a5uwjf	305	41	from	from	IN
cord-270337-92a5uwjf	305	42	the	the	DT
cord-270337-92a5uwjf	305	43	strategic	strategic	JJ
cord-270337-92a5uwjf	305	44	national	national	JJ
cord-270337-92a5uwjf	305	45	stockpile	stockpile	NN
cord-270337-92a5uwjf	305	46	for	for	IN
cord-270337-92a5uwjf	305	47	treatment	treatment	NN
cord-270337-92a5uwjf	305	48	of	of	IN
cord-270337-92a5uwjf	305	49	2019	2019	CD
cord-270337-92a5uwjf	305	50	coronavirus	coronavirus	NN
cord-270337-92a5uwjf	305	51	disease	disease	NN
cord-270337-92a5uwjf	305	52	Les	Les	NNP
cord-270337-92a5uwjf	305	53	effets	effets	NNP
cord-270337-92a5uwjf	305	54	antagonistes	antagonistes	NNP
cord-270337-92a5uwjf	305	55	du	du	NNP
cord-270337-92a5uwjf	305	56	diazépam	diazépam	NNP
cord-270337-92a5uwjf	305	57	et	et	NNP
cord-270337-92a5uwjf	305	58	du	du	NNP
cord-270337-92a5uwjf	305	59	Ro5	Ro5	NNP
cord-270337-92a5uwjf	305	60	-	-	CD
cord-270337-92a5uwjf	305	61	4864	4864	CD
cord-270337-92a5uwjf	306	1	dans	dans	NNP
cord-270337-92a5uwjf	306	2	l'intoxication	l'intoxication	NNP
cord-270337-92a5uwjf	306	3	aiguë	aiguë	NNP
cord-270337-92a5uwjf	306	4	par	par	NNP
cord-270337-92a5uwjf	307	1	la	la	NNP
cord-270337-92a5uwjf	307	2	chloroquine	chloroquine	NNP
cord-270337-92a5uwjf	308	1	chez	chez	NNP
cord-270337-92a5uwjf	308	2	le	le	NNP
cord-270337-92a5uwjf	309	1	rat	rat	NNP
cord-270337-92a5uwjf	309	2	et	et	FW
cord-270337-92a5uwjf	309	3	chez	chez	FW
cord-270337-92a5uwjf	309	4	le	le	NNP
cord-270337-92a5uwjf	310	1	cobaye	cobaye	NNP
cord-270337-92a5uwjf	311	1	sont	sont	NNP
cord-270337-92a5uwjf	311	2	-	-	HYPH
cord-270337-92a5uwjf	311	3	ils	ils	NNP
cord-270337-92a5uwjf	311	4	de	de	IN
cord-270337-92a5uwjf	311	5	nature	nature	NNP
cord-270337-92a5uwjf	311	6	centrale	centrale	NNP
cord-270337-92a5uwjf	311	7	ou	ou	FW
cord-270337-92a5uwjf	311	8	périphérique	périphérique	NN
cord-270337-92a5uwjf	311	9	?	?	.
cord-270337-92a5uwjf	312	1	The	the	DT
cord-270337-92a5uwjf	312	2	IUPHAR	IUPHAR	NNP
cord-270337-92a5uwjf	312	3	/	/	SYM
cord-270337-92a5uwjf	312	4	BPS	BPS	NNP
cord-270337-92a5uwjf	312	5	Guide	Guide	NNP
cord-270337-92a5uwjf	312	6	to	to	IN
cord-270337-92a5uwjf	312	7	PHAR	PHAR	NNP
cord-270337-92a5uwjf	312	8	-	-	HYPH
cord-270337-92a5uwjf	312	9	MACOLOGY	MACOLOGY	NNP
cord-270337-92a5uwjf	312	10	in	in	IN
cord-270337-92a5uwjf	312	11	2018	2018	CD
cord-270337-92a5uwjf	312	12	:	:	:
cord-270337-92a5uwjf	313	1	Updates	update	NNS
cord-270337-92a5uwjf	313	2	and	and	CC
cord-270337-92a5uwjf	313	3	expansion	expansion	NN
cord-270337-92a5uwjf	313	4	to	to	TO
cord-270337-92a5uwjf	313	5	encompass	encompass	VB
cord-270337-92a5uwjf	313	6	the	the	DT
cord-270337-92a5uwjf	313	7	new	new	JJ
cord-270337-92a5uwjf	313	8	guide	guide	NN
cord-270337-92a5uwjf	313	9	to	to	IN
cord-270337-92a5uwjf	313	10	IMMUNOPHARMACOLOGY	IMMUNOPHARMACOLOGY	NNP
cord-270337-92a5uwjf	314	1	The	the	DT
cord-270337-92a5uwjf	314	2	effects	effect	NNS
cord-270337-92a5uwjf	314	3	of	of	IN
cord-270337-92a5uwjf	314	4	calcium	calcium	NN
cord-270337-92a5uwjf	314	5	ions	ion	NNS
cord-270337-92a5uwjf	314	6	on	on	IN
cord-270337-92a5uwjf	314	7	the	the	DT
cord-270337-92a5uwjf	314	8	depression	depression	NN
cord-270337-92a5uwjf	314	9	of	of	IN
cord-270337-92a5uwjf	314	10	cardiac	cardiac	JJ
cord-270337-92a5uwjf	314	11	contractility	contractility	NN
cord-270337-92a5uwjf	314	12	by	by	IN
cord-270337-92a5uwjf	314	13	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	314	14	and	and	CC
cord-270337-92a5uwjf	314	15	quinine	quinine	NN
cord-270337-92a5uwjf	314	16	Clinical	clinical	JJ
cord-270337-92a5uwjf	314	17	features	feature	NNS
cord-270337-92a5uwjf	314	18	and	and	CC
cord-270337-92a5uwjf	314	19	management	management	NN
cord-270337-92a5uwjf	314	20	of	of	IN
cord-270337-92a5uwjf	314	21	poisoning	poisoning	NN
cord-270337-92a5uwjf	314	22	due	due	IN
cord-270337-92a5uwjf	314	23	to	to	IN
cord-270337-92a5uwjf	314	24	antimalarial	antimalarial	JJ
cord-270337-92a5uwjf	314	25	drugs	drug	NNS
cord-270337-92a5uwjf	314	26	Critical	critical	JJ
cord-270337-92a5uwjf	314	27	care	care	NN
cord-270337-92a5uwjf	314	28	toxicology	toxicology	NN
cord-270337-92a5uwjf	314	29	:	:	:
cord-270337-92a5uwjf	314	30	Diagnosis	diagnosis	NN
cord-270337-92a5uwjf	314	31	and	and	CC
cord-270337-92a5uwjf	314	32	management	management	NN
cord-270337-92a5uwjf	314	33	of	of	IN
cord-270337-92a5uwjf	314	34	the	the	DT
cord-270337-92a5uwjf	314	35	critically	critically	RB
cord-270337-92a5uwjf	314	36	poisoned	poison	VBN
cord-270337-92a5uwjf	314	37	patient	patient	NN
cord-270337-92a5uwjf	314	38	Comparative	Comparative	NNP
cord-270337-92a5uwjf	314	39	actions	action	NNS
cord-270337-92a5uwjf	314	40	of	of	IN
cord-270337-92a5uwjf	314	41	diazepam	diazepam	NN
cord-270337-92a5uwjf	314	42	and	and	CC
cord-270337-92a5uwjf	314	43	other	other	JJ
cord-270337-92a5uwjf	314	44	phosphodiesterase	phosphodiesterase	NN
cord-270337-92a5uwjf	314	45	inhibitors	inhibitor	NNS
cord-270337-92a5uwjf	314	46	on	on	IN
cord-270337-92a5uwjf	314	47	the	the	DT
cord-270337-92a5uwjf	314	48	effects	effect	NNS
cord-270337-92a5uwjf	314	49	of	of	IN
cord-270337-92a5uwjf	314	50	noradrenaline	noradrenaline	NN
cord-270337-92a5uwjf	314	51	in	in	IN
cord-270337-92a5uwjf	314	52	rat	rat	NN
cord-270337-92a5uwjf	314	53	myocardium	myocardium	NN
cord-270337-92a5uwjf	315	1	Diazepam	Diazepam	NNP
cord-270337-92a5uwjf	315	2	enhances	enhance	VBZ
cord-270337-92a5uwjf	315	3	inotropic	inotropic	JJ
cord-270337-92a5uwjf	315	4	responses	response	NNS
cord-270337-92a5uwjf	315	5	to	to	IN
cord-270337-92a5uwjf	315	6	dopamine	dopamine	NN
cord-270337-92a5uwjf	315	7	in	in	IN
cord-270337-92a5uwjf	315	8	rat	rat	NN
cord-270337-92a5uwjf	315	9	ventricular	ventricular	JJ
cord-270337-92a5uwjf	315	10	myocardium	myocardium	NN
cord-270337-92a5uwjf	315	11	.	.	.
cord-270337-92a5uwjf	316	1	Anesthesia	Anesthesia	NNP
cord-270337-92a5uwjf	316	2	and	and	CC
cord-270337-92a5uwjf	316	3	Analgesia	Analgesia	NNP
cord-270337-92a5uwjf	316	4	Animal	Animal	NNP
cord-270337-92a5uwjf	316	5	research	research	NN
cord-270337-92a5uwjf	316	6	:	:	:
cord-270337-92a5uwjf	316	7	Reporting	report	VBG
cord-270337-92a5uwjf	316	8	in	in	IN
cord-270337-92a5uwjf	316	9	vivo	vivo	NN
cord-270337-92a5uwjf	316	10	experiments	experiment	NNS
cord-270337-92a5uwjf	316	11	:	:	:
cord-270337-92a5uwjf	316	12	The	the	DT
cord-270337-92a5uwjf	316	13	ARRIVE	ARRIVE	NNP
cord-270337-92a5uwjf	316	14	guidelines	guideline	NNS
cord-270337-92a5uwjf	316	15	Blockade	Blockade	NNP
cord-270337-92a5uwjf	316	16	of	of	IN
cord-270337-92a5uwjf	316	17	hERG	hERG	NNP
cord-270337-92a5uwjf	316	18	K(+	K(+	NNP
cord-270337-92a5uwjf	316	19	)	)	-RRB-
cord-270337-92a5uwjf	316	20	channel	channel	NNP
cord-270337-92a5uwjf	316	21	by	by	IN
cord-270337-92a5uwjf	316	22	antimalarial	antimalarial	JJ
cord-270337-92a5uwjf	316	23	drug	drug	NN
cord-270337-92a5uwjf	316	24	,	,	,
cord-270337-92a5uwjf	316	25	primaquine	primaquine	NNP
cord-270337-92a5uwjf	316	26	Demonstration	demonstration	NN
cord-270337-92a5uwjf	316	27	of	of	IN
cord-270337-92a5uwjf	316	28	a	a	DT
cord-270337-92a5uwjf	316	29	different	different	JJ
cord-270337-92a5uwjf	316	30	sensitivity	sensitivity	NN
cord-270337-92a5uwjf	316	31	to	to	IN
cord-270337-92a5uwjf	316	32	epinephrine	epinephrine	NN
cord-270337-92a5uwjf	316	33	in	in	IN
cord-270337-92a5uwjf	316	34	isolated	isolated	JJ
cord-270337-92a5uwjf	316	35	and	and	CC
cord-270337-92a5uwjf	316	36	in	in	IN
cord-270337-92a5uwjf	316	37	vivo	vivo	FW
cord-270337-92a5uwjf	316	38	hearts	heart	NNS
cord-270337-92a5uwjf	317	1	Cardiovascular	cardiovascular	JJ
cord-270337-92a5uwjf	317	2	toxicity	toxicity	NN
cord-270337-92a5uwjf	317	3	and	and	CC
cord-270337-92a5uwjf	317	4	distribution	distribution	NN
cord-270337-92a5uwjf	317	5	kinetics	kinetic	NNS
cord-270337-92a5uwjf	317	6	of	of	IN
cord-270337-92a5uwjf	317	7	intravenous	intravenous	JJ
cord-270337-92a5uwjf	317	8	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	317	9	Diazepam	Diazepam	NNP
cord-270337-92a5uwjf	317	10	potentiates	potentiate	VBZ
cord-270337-92a5uwjf	317	11	the	the	DT
cord-270337-92a5uwjf	317	12	positive	positive	JJ
cord-270337-92a5uwjf	317	13	inotropic	inotropic	JJ
cord-270337-92a5uwjf	317	14	effect	effect	NN
cord-270337-92a5uwjf	317	15	of	of	IN
cord-270337-92a5uwjf	317	16	isoprenaline	isoprenaline	NN
cord-270337-92a5uwjf	317	17	in	in	IN
cord-270337-92a5uwjf	317	18	rat	rat	NN
cord-270337-92a5uwjf	317	19	ventricle	ventricle	NN
cord-270337-92a5uwjf	317	20	strips	strip	NNS
cord-270337-92a5uwjf	317	21	:	:	:
cord-270337-92a5uwjf	317	22	Role	role	NN
cord-270337-92a5uwjf	317	23	of	of	IN
cord-270337-92a5uwjf	317	24	cyclic	cyclic	JJ
cord-270337-92a5uwjf	317	25	AMP	AMP	NNP
cord-270337-92a5uwjf	317	26	Transparency	Transparency	NNP
cord-270337-92a5uwjf	317	27	in	in	IN
cord-270337-92a5uwjf	317	28	research	research	NN
cord-270337-92a5uwjf	317	29	involving	involve	VBG
cord-270337-92a5uwjf	317	30	animals	animal	NNS
cord-270337-92a5uwjf	317	31	:	:	:
cord-270337-92a5uwjf	317	32	The	the	DT
cord-270337-92a5uwjf	317	33	Basel	Basel	NNP
cord-270337-92a5uwjf	317	34	Declaration	Declaration	NNP
cord-270337-92a5uwjf	317	35	and	and	CC
cord-270337-92a5uwjf	317	36	new	new	JJ
cord-270337-92a5uwjf	317	37	principles	principle	NNS
cord-270337-92a5uwjf	317	38	for	for	IN
cord-270337-92a5uwjf	317	39	reporting	report	VBG
cord-270337-92a5uwjf	317	40	research	research	NN
cord-270337-92a5uwjf	317	41	in	in	IN
cord-270337-92a5uwjf	317	42	BJP	BJP	NNP
cord-270337-92a5uwjf	317	43	manuscripts	manuscript	NNS
cord-270337-92a5uwjf	317	44	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	317	45	poisoning	poisoning	NN
cord-270337-92a5uwjf	317	46	.	.	.
cord-270337-92a5uwjf	318	1	Rapidly	rapidly	RB
cord-270337-92a5uwjf	318	2	fatal	fatal	JJ
cord-270337-92a5uwjf	318	3	without	without	IN
cord-270337-92a5uwjf	318	4	treatment	treatment	NN
cord-270337-92a5uwjf	318	5	Blood	blood	NN
cord-270337-92a5uwjf	318	6	concentrations	concentration	NNS
cord-270337-92a5uwjf	318	7	are	be	VBP
cord-270337-92a5uwjf	318	8	better	well	JJR
cord-270337-92a5uwjf	318	9	predictors	predictor	NNS
cord-270337-92a5uwjf	318	10	of	of	IN
cord-270337-92a5uwjf	318	11	chioroquine	chioroquine	NN
cord-270337-92a5uwjf	318	12	poisoning	poisoning	NN
cord-270337-92a5uwjf	318	13	severity	severity	NN
cord-270337-92a5uwjf	318	14	than	than	IN
cord-270337-92a5uwjf	318	15	plasma	plasma	NN
cord-270337-92a5uwjf	318	16	concentrations	concentration	NNS
cord-270337-92a5uwjf	318	17	:	:	:
cord-270337-92a5uwjf	318	18	A	a	DT
cord-270337-92a5uwjf	318	19	prospective	prospective	JJ
cord-270337-92a5uwjf	318	20	study	study	NN
cord-270337-92a5uwjf	318	21	with	with	IN
cord-270337-92a5uwjf	318	22	modeling	modeling	NN
cord-270337-92a5uwjf	318	23	of	of	IN
cord-270337-92a5uwjf	318	24	the	the	DT
cord-270337-92a5uwjf	318	25	concentration	concentration	NN
cord-270337-92a5uwjf	318	26	/	/	SYM
cord-270337-92a5uwjf	318	27	effect	effect	NN
cord-270337-92a5uwjf	318	28	relationships	relationship	NNS
cord-270337-92a5uwjf	318	29	Effects	effect	NNS
cord-270337-92a5uwjf	318	30	of	of	IN
cord-270337-92a5uwjf	318	31	quinine	quinine	NN
cord-270337-92a5uwjf	318	32	and	and	CC
cord-270337-92a5uwjf	318	33	quinidine	quinidine	NN
cord-270337-92a5uwjf	318	34	on	on	IN
cord-270337-92a5uwjf	318	35	the	the	DT
cord-270337-92a5uwjf	318	36	transient	transient	JJ
cord-270337-92a5uwjf	318	37	outward	outward	RB
cord-270337-92a5uwjf	318	38	and	and	CC
cord-270337-92a5uwjf	318	39	on	on	IN
cord-270337-92a5uwjf	318	40	the	the	DT
cord-270337-92a5uwjf	318	41	L	l	NN
cord-270337-92a5uwjf	318	42	-	-	HYPH
cord-270337-92a5uwjf	318	43	type	type	NN
cord-270337-92a5uwjf	318	44	Ca	Ca	NNP
cord-270337-92a5uwjf	318	45	2	2	CD
cord-270337-92a5uwjf	318	46	+	+	NN
cord-270337-92a5uwjf	318	47	current	current	NN
cord-270337-92a5uwjf	318	48	in	in	IN
cord-270337-92a5uwjf	318	49	rat	rat	NN
cord-270337-92a5uwjf	318	50	ventricular	ventricular	JJ
cord-270337-92a5uwjf	318	51	cardiomyocytes	cardiomyocyte	NNS
cord-270337-92a5uwjf	319	1	A	a	DT
cord-270337-92a5uwjf	319	2	simple	simple	JJ
cord-270337-92a5uwjf	319	3	practice	practice	NN
cord-270337-92a5uwjf	319	4	guide	guide	NN
cord-270337-92a5uwjf	319	5	for	for	IN
cord-270337-92a5uwjf	319	6	dose	dose	JJ
cord-270337-92a5uwjf	319	7	conversion	conversion	NN
cord-270337-92a5uwjf	319	8	between	between	IN
cord-270337-92a5uwjf	319	9	animals	animal	NNS
cord-270337-92a5uwjf	319	10	and	and	CC
cord-270337-92a5uwjf	319	11	human	human	JJ
cord-270337-92a5uwjf	319	12	The	the	DT
cord-270337-92a5uwjf	319	13	determinants	determinant	NNS
cord-270337-92a5uwjf	319	14	of	of	IN
cord-270337-92a5uwjf	319	15	contractility	contractility	NN
cord-270337-92a5uwjf	319	16	in	in	IN
cord-270337-92a5uwjf	319	17	the	the	DT
cord-270337-92a5uwjf	319	18	heart	heart	NN
cord-270337-92a5uwjf	320	1	The	the	DT
cord-270337-92a5uwjf	320	2	use	use	NN
cord-270337-92a5uwjf	320	3	of	of	IN
cord-270337-92a5uwjf	320	4	diazepam	diazepam	NN
cord-270337-92a5uwjf	320	5	in	in	IN
cord-270337-92a5uwjf	320	6	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	320	7	poisoning	poisoning	NN
cord-270337-92a5uwjf	320	8	Action	action	NN
cord-270337-92a5uwjf	320	9	of	of	IN
cord-270337-92a5uwjf	320	10	antiarrhythmic	antiarrhythmic	NN
cord-270337-92a5uwjf	320	11	and	and	CC
cord-270337-92a5uwjf	320	12	-receptor	-receptor	NN
cord-270337-92a5uwjf	320	13	blocking	block	VBG
cord-270337-92a5uwjf	320	14	drugs	drug	NNS
cord-270337-92a5uwjf	320	15	on	on	IN
cord-270337-92a5uwjf	320	16	functional	functional	JJ
cord-270337-92a5uwjf	320	17	refractory	refractory	JJ
cord-270337-92a5uwjf	320	18	period	period	NN
cord-270337-92a5uwjf	320	19	and	and	CC
cord-270337-92a5uwjf	320	20	contractility	contractility	NN
cord-270337-92a5uwjf	320	21	of	of	IN
cord-270337-92a5uwjf	320	22	electrically	electrically	RB
cord-270337-92a5uwjf	320	23	stimulated	stimulate	VBN
cord-270337-92a5uwjf	320	24	guinea	guinea	NN
cord-270337-92a5uwjf	320	25	-	-	HYPH
cord-270337-92a5uwjf	320	26	pig	pig	NN
cord-270337-92a5uwjf	320	27	atria	atria	NN
cord-270337-92a5uwjf	320	28	Conserved	conserved	JJ
cord-270337-92a5uwjf	320	29	expression	expression	NN
cord-270337-92a5uwjf	320	30	and	and	CC
cord-270337-92a5uwjf	320	31	functions	function	NNS
cord-270337-92a5uwjf	320	32	of	of	IN
cord-270337-92a5uwjf	320	33	PDE4	PDE4	NNP
cord-270337-92a5uwjf	320	34	in	in	IN
cord-270337-92a5uwjf	320	35	rodent	rodent	NN
cord-270337-92a5uwjf	320	36	and	and	CC
cord-270337-92a5uwjf	320	37	human	human	JJ
cord-270337-92a5uwjf	320	38	heart	heart	NN
cord-270337-92a5uwjf	320	39	Treatment	Treatment	NNP
cord-270337-92a5uwjf	320	40	of	of	IN
cord-270337-92a5uwjf	320	41	severe	severe	JJ
cord-270337-92a5uwjf	320	42	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	320	43	poisoning	poisoning	NN
cord-270337-92a5uwjf	320	44	Diazepam	Diazepam	NNP
cord-270337-92a5uwjf	320	45	does	do	VBZ
cord-270337-92a5uwjf	320	46	not	not	RB
cord-270337-92a5uwjf	320	47	improve	improve	VB
cord-270337-92a5uwjf	320	48	the	the	DT
cord-270337-92a5uwjf	320	49	mechanical	mechanical	JJ
cord-270337-92a5uwjf	320	50	performance	performance	NN
cord-270337-92a5uwjf	320	51	of	of	IN
cord-270337-92a5uwjf	320	52	rat	rat	NN
cord-270337-92a5uwjf	320	53	cardiac	cardiac	JJ
cord-270337-92a5uwjf	320	54	papillary	papillary	JJ
cord-270337-92a5uwjf	320	55	muscle	muscle	NN
cord-270337-92a5uwjf	320	56	exposed	expose	VBN
cord-270337-92a5uwjf	320	57	to	to	IN
cord-270337-92a5uwjf	320	58	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	320	59	in	in	IN
cord-270337-92a5uwjf	320	60	vitro	vitro	FW
cord-270337-92a5uwjf	320	61	Protective	protective	JJ
cord-270337-92a5uwjf	320	62	cardiovascular	cardiovascular	JJ
cord-270337-92a5uwjf	320	63	effects	effect	NNS
cord-270337-92a5uwjf	320	64	of	of	IN
cord-270337-92a5uwjf	320	65	diazepam	diazepam	NN
cord-270337-92a5uwjf	320	66	in	in	IN
cord-270337-92a5uwjf	320	67	experimental	experimental	JJ
cord-270337-92a5uwjf	320	68	acute	acute	JJ
cord-270337-92a5uwjf	320	69	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	320	70	poisoning	poisoning	NN
cord-270337-92a5uwjf	320	71	The	the	DT
cord-270337-92a5uwjf	320	72	molecular	molecular	JJ
cord-270337-92a5uwjf	320	73	basis	basis	NN
cord-270337-92a5uwjf	320	74	of	of	IN
cord-270337-92a5uwjf	320	75	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	320	76	block	block	NN
cord-270337-92a5uwjf	320	77	of	of	IN
cord-270337-92a5uwjf	320	78	the	the	DT
cord-270337-92a5uwjf	320	79	inward	inward	JJ
cord-270337-92a5uwjf	320	80	rectifier	rectifier	NN
cord-270337-92a5uwjf	320	81	Kir2.1	Kir2.1	NNP
cord-270337-92a5uwjf	320	82	channel	channel	NN
cord-270337-92a5uwjf	320	83	Chloroquine	Chloroquine	NNP
cord-270337-92a5uwjf	320	84	selectively	selectively	RB
cord-270337-92a5uwjf	320	85	blocks	block	VBZ
cord-270337-92a5uwjf	320	86	the	the	DT
cord-270337-92a5uwjf	320	87	inward	inward	JJ
cord-270337-92a5uwjf	320	88	rectifying	rectify	VBG
cord-270337-92a5uwjf	320	89	potassium	potassium	NN
cord-270337-92a5uwjf	320	90	channel	channel	NN
cord-270337-92a5uwjf	320	91	in	in	IN
cord-270337-92a5uwjf	320	92	dog	dog	NN
cord-270337-92a5uwjf	320	93	cardiac	cardiac	NN
cord-270337-92a5uwjf	320	94	myocytes	myocyte	NNS
cord-270337-92a5uwjf	320	95	Blockade	Blockade	NNP
cord-270337-92a5uwjf	320	96	of	of	IN
cord-270337-92a5uwjf	320	97	currents	current	NNS
cord-270337-92a5uwjf	320	98	by	by	IN
cord-270337-92a5uwjf	320	99	the	the	DT
cord-270337-92a5uwjf	320	100	antimalarial	antimalarial	JJ
cord-270337-92a5uwjf	320	101	drug	drug	NN
cord-270337-92a5uwjf	320	102	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	320	103	in	in	IN
cord-270337-92a5uwjf	320	104	feline	feline	JJ
cord-270337-92a5uwjf	320	105	ventricular	ventricular	JJ
cord-270337-92a5uwjf	320	106	myocytes	myocyte	NNS
cord-270337-92a5uwjf	320	107	4-year	4-year	JJ
cord-270337-92a5uwjf	320	108	-	-	HYPH
cord-270337-92a5uwjf	320	109	old	old	JJ
cord-270337-92a5uwjf	320	110	girl	girl	NN
cord-270337-92a5uwjf	320	111	near	near	IN
cord-270337-92a5uwjf	320	112	Coimbatore	Coimbatore	NNP
cord-270337-92a5uwjf	320	113	dies	die	VBZ
cord-270337-92a5uwjf	320	114	after	after	IN
cord-270337-92a5uwjf	320	115	parents	parent	NNS
cord-270337-92a5uwjf	320	116	administer	administer	VBP
cord-270337-92a5uwjf	320	117	hydroxy	hydroxy	NN
cord-270337-92a5uwjf	320	118	-	-	HYPH
cord-270337-92a5uwjf	320	119	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	320	120	drug	drug	NN
cord-270337-92a5uwjf	320	121	as	as	IN
cord-270337-92a5uwjf	320	122	COVID-19	covid-19	JJ
cord-270337-92a5uwjf	320	123	preventive	preventive	JJ
cord-270337-92a5uwjf	320	124	medicine	medicine	NN
cord-270337-92a5uwjf	320	125	The	the	DT
cord-270337-92a5uwjf	320	126	cardiovascular	cardiovascular	JJ
cord-270337-92a5uwjf	320	127	effect	effect	NN
cord-270337-92a5uwjf	320	128	of	of	IN
cord-270337-92a5uwjf	320	129	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	320	130	in	in	IN
cord-270337-92a5uwjf	320	131	anaesthetized	anaesthetize	VBN
cord-270337-92a5uwjf	320	132	dogs	dog	NNS
cord-270337-92a5uwjf	320	133	Roles	role	NNS
cord-270337-92a5uwjf	320	134	of	of	IN
cord-270337-92a5uwjf	320	135	mitochondrial	mitochondrial	JJ
cord-270337-92a5uwjf	320	136	benzodiazepine	benzodiazepine	NN
cord-270337-92a5uwjf	320	137	receptor	receptor	NN
cord-270337-92a5uwjf	320	138	in	in	IN
cord-270337-92a5uwjf	320	139	the	the	DT
cord-270337-92a5uwjf	320	140	heart	heart	NN
cord-270337-92a5uwjf	320	141	Depressant	depressant	JJ
cord-270337-92a5uwjf	320	142	effects	effect	NNS
cord-270337-92a5uwjf	320	143	of	of	IN
cord-270337-92a5uwjf	320	144	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	320	145	on	on	IN
cord-270337-92a5uwjf	320	146	the	the	DT
cord-270337-92a5uwjf	320	147	isolated	isolate	VBN
cord-270337-92a5uwjf	320	148	guinea	guinea	NN
cord-270337-92a5uwjf	320	149	-	-	HYPH
cord-270337-92a5uwjf	320	150	pig	pig	NN
cord-270337-92a5uwjf	320	151	heart	heart	NN
cord-270337-92a5uwjf	320	152	Structural	structural	JJ
cord-270337-92a5uwjf	320	153	requirements	requirement	NNS
cord-270337-92a5uwjf	320	154	for	for	IN
cord-270337-92a5uwjf	320	155	the	the	DT
cord-270337-92a5uwjf	320	156	binding	binding	NN
cord-270337-92a5uwjf	320	157	of	of	IN
cord-270337-92a5uwjf	320	158	benzodiazepines	benzodiazepine	NNS
cord-270337-92a5uwjf	320	159	to	to	IN
cord-270337-92a5uwjf	320	160	their	-PRON-	PRP$
cord-270337-92a5uwjf	320	161	peripheral	peripheral	JJ
cord-270337-92a5uwjf	320	162	-	-	HYPH
cord-270337-92a5uwjf	320	163	type	type	NN
cord-270337-92a5uwjf	320	164	sites	site	NNS
cord-270337-92a5uwjf	320	165	Review	Review	NNP
cord-270337-92a5uwjf	320	166	of	of	IN
cord-270337-92a5uwjf	320	167	side	side	JJ
cord-270337-92a5uwjf	320	168	effects	effect	NNS
cord-270337-92a5uwjf	320	169	and	and	CC
cord-270337-92a5uwjf	320	170	toxicity	toxicity	NN
cord-270337-92a5uwjf	320	171	of	of	IN
cord-270337-92a5uwjf	320	172	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	320	173	/	/	,
cord-270337-92a5uwjf	320	174	by	by	IN
cord-270337-92a5uwjf	320	175	H.	H.	NNP
cord-270337-92a5uwjf	320	176	Weniger	Weniger	NNP
cord-270337-92a5uwjf	320	177	.	.	.
cord-270337-92a5uwjf	321	1	Geneva	Geneva	NNP
cord-270337-92a5uwjf	321	2	:	:	:
cord-270337-92a5uwjf	322	1	World	World	NNP
cord-270337-92a5uwjf	322	2	health	health	NNP
cord-270337-92a5uwjf	322	3	Organization	Organization	NNP
cord-270337-92a5uwjf	323	1	The	the	DT
cord-270337-92a5uwjf	323	2	cardiotoxicity	cardiotoxicity	NN
cord-270337-92a5uwjf	323	3	of	of	IN
cord-270337-92a5uwjf	323	4	antimalarials	antimalarial	NNS
cord-270337-92a5uwjf	323	5	.	.	.
cord-270337-92a5uwjf	324	1	Malaria	Malaria	NNP
cord-270337-92a5uwjf	324	2	Policy	Policy	NNP
cord-270337-92a5uwjf	324	3	Advisory	Advisory	NNP
cord-270337-92a5uwjf	324	4	Committee	Committee	NNP
cord-270337-92a5uwjf	324	5	Wuhan	Wuhan	NNP
cord-270337-92a5uwjf	324	6	woman	woman	NN
cord-270337-92a5uwjf	324	7	who	who	WP
cord-270337-92a5uwjf	324	8	was	be	VBD
cord-270337-92a5uwjf	324	9	not	not	RB
cord-270337-92a5uwjf	324	10	infected	infect	VBN
cord-270337-92a5uwjf	324	11	with	with	IN
cord-270337-92a5uwjf	324	12	the	the	DT
cord-270337-92a5uwjf	324	13	new	new	JJ
cord-270337-92a5uwjf	324	14	coronavirus	coronavirus	NN
cord-270337-92a5uwjf	324	15	,	,	,
cord-270337-92a5uwjf	324	16	but	but	CC
cord-270337-92a5uwjf	324	17	bought	buy	VBD
cord-270337-92a5uwjf	324	18	and	and	CC
cord-270337-92a5uwjf	324	19	overdosed	overdose	VBD
cord-270337-92a5uwjf	324	20	on	on	IN
cord-270337-92a5uwjf	324	21	prescription	prescription	NN
cord-270337-92a5uwjf	324	22	drugs	drug	NNS
cord-270337-92a5uwjf	324	23	,	,	,
cord-270337-92a5uwjf	324	24	was	be	VBD
cord-270337-92a5uwjf	324	25	sent	send	VBN
cord-270337-92a5uwjf	324	26	to	to	IN
cord-270337-92a5uwjf	324	27	ICU	ICU	NNP
cord-270337-92a5uwjf	324	28	.	.	.
cord-270337-92a5uwjf	325	1	The	the	DT
cord-270337-92a5uwjf	325	2	Paper	Paper	NNP
cord-270337-92a5uwjf	325	3	Diazepam	diazepam	NN
cord-270337-92a5uwjf	325	4	for	for	IN
cord-270337-92a5uwjf	325	5	treatment	treatment	NN
cord-270337-92a5uwjf	325	6	of	of	IN
cord-270337-92a5uwjf	325	7	massive	massive	JJ
cord-270337-92a5uwjf	325	8	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	325	9	intoxication	intoxication	NN
cord-270337-92a5uwjf	325	10	Cardiac	cardiac	JJ
cord-270337-92a5uwjf	325	11	effects	effect	NNS
cord-270337-92a5uwjf	325	12	of	of	IN
cord-270337-92a5uwjf	325	13	benzodiazepine	benzodiazepine	NN
cord-270337-92a5uwjf	325	14	receptor	receptor	NN
cord-270337-92a5uwjf	325	15	agonists	agonist	NNS
cord-270337-92a5uwjf	325	16	and	and	CC
cord-270337-92a5uwjf	325	17	antagonists	antagonist	NNS
cord-270337-92a5uwjf	325	18	in	in	IN
cord-270337-92a5uwjf	325	19	the	the	DT
cord-270337-92a5uwjf	325	20	isolated	isolate	VBN
cord-270337-92a5uwjf	325	21	rat	rat	NN
cord-270337-92a5uwjf	325	22	heart	heart	NN
cord-270337-92a5uwjf	325	23	:	:	:
cord-270337-92a5uwjf	326	1	A	a	DT
cord-270337-92a5uwjf	326	2	comparative	comparative	JJ
cord-270337-92a5uwjf	326	3	study	study	NN
cord-270337-92a5uwjf	326	4	Acute	acute	JJ
cord-270337-92a5uwjf	326	5	chloroquine	chloroquine	NN
cord-270337-92a5uwjf	326	6	poisoning	poisoning	NN
cord-270337-92a5uwjf	326	7	:	:	:
cord-270337-92a5uwjf	326	8	A	a	DT
cord-270337-92a5uwjf	326	9	comprehensive	comprehensive	JJ
cord-270337-92a5uwjf	326	10	experimental	experimental	JJ
cord-270337-92a5uwjf	326	11	toxicology	toxicology	NN
cord-270337-92a5uwjf	326	12	assessment	assessment	NN
cord-270337-92a5uwjf	326	13	of	of	IN
cord-270337-92a5uwjf	326	14	the	the	DT
cord-270337-92a5uwjf	326	15	role	role	NN
cord-270337-92a5uwjf	326	16	of	of	IN
cord-270337-92a5uwjf	326	17	diazepam	diazepam	NN
cord-270337-92a5uwjf	327	1	The	the	DT
cord-270337-92a5uwjf	327	2	author	author	NN
cord-270337-92a5uwjf	327	3	declares	declare	VBZ
cord-270337-92a5uwjf	327	4	no	no	DT
cord-270337-92a5uwjf	327	5	conflicts	conflict	NNS
cord-270337-92a5uwjf	327	6	of	of	IN
cord-270337-92a5uwjf	327	7	interest	interest	NN
cord-270337-92a5uwjf	327	8	.	.	.
cord-270337-92a5uwjf	328	1	This	this	DT
cord-270337-92a5uwjf	328	2	Declaration	Declaration	NNP
cord-270337-92a5uwjf	328	3	acknowledges	acknowledge	VBZ
cord-270337-92a5uwjf	328	4	that	that	IN
cord-270337-92a5uwjf	328	5	this	this	DT
cord-270337-92a5uwjf	328	6	paper	paper	NN
cord-270337-92a5uwjf	328	7	adheres	adhere	VBZ
cord-270337-92a5uwjf	328	8	to	to	IN
cord-270337-92a5uwjf	328	9	the	the	DT
cord-270337-92a5uwjf	328	10	principles	principle	NNS
cord-270337-92a5uwjf	328	11	for	for	IN
cord-270337-92a5uwjf	328	12	transparent	transparent	JJ
cord-270337-92a5uwjf	328	13	reporting	reporting	NN
cord-270337-92a5uwjf	328	14	and	and	CC
cord-270337-92a5uwjf	328	15	scientific	scientific	JJ
cord-270337-92a5uwjf	328	16	rigour	rigour	NN
cord-270337-92a5uwjf	328	17	of	of	IN
cord-270337-92a5uwjf	328	18	preclinical	preclinical	JJ
cord-270337-92a5uwjf	328	19	research	research	NN
cord-270337-92a5uwjf	328	20	as	as	IN
cord-270337-92a5uwjf	328	21	stated	state	VBN
cord-270337-92a5uwjf	328	22	in	in	IN
cord-270337-92a5uwjf	328	23	the	the	DT
cord-270337-92a5uwjf	328	24	BJP	BJP	NNP
cord-270337-92a5uwjf	328	25	guidelines	guideline	NNS
cord-270337-92a5uwjf	328	26	for	for	IN
cord-270337-92a5uwjf	328	27	Design	Design	NNP
cord-270337-92a5uwjf	328	28	and	and	CC
cord-270337-92a5uwjf	328	29	Analysis	Analysis	NNP
cord-270337-92a5uwjf	328	30	and	and	CC
cord-270337-92a5uwjf	328	31	Animal	Animal	NNP
cord-270337-92a5uwjf	328	32	Experimentation	Experimentation	NNP
cord-270337-92a5uwjf	328	33	,	,	,
cord-270337-92a5uwjf	328	34	and	and	CC
cord-270337-92a5uwjf	328	35	as	as	IN
cord-270337-92a5uwjf	328	36	recommended	recommend	VBN
cord-270337-92a5uwjf	328	37	by	by	IN
cord-270337-92a5uwjf	328	38	funding	fund	VBG
cord-270337-92a5uwjf	328	39	agencies	agency	NNS
cord-270337-92a5uwjf	328	40	,	,	,
cord-270337-92a5uwjf	328	41	publishers	publisher	NNS
cord-270337-92a5uwjf	328	42	,	,	,
cord-270337-92a5uwjf	328	43	and	and	CC
cord-270337-92a5uwjf	328	44	other	other	JJ
cord-270337-92a5uwjf	328	45	organisations	organisation	NNS
cord-270337-92a5uwjf	328	46	engaged	engage	VBN
cord-270337-92a5uwjf	328	47	with	with	IN
cord-270337-92a5uwjf	328	48	supporting	support	VBG
cord-270337-92a5uwjf	328	49	research	research	NN
cord-270337-92a5uwjf	328	50	.	.	.
cord-270337-92a5uwjf	329	1	Adrenaline	adrenaline	NN
cord-270337-92a5uwjf	330	1	Diazepam	Diazepam	NNP
cord-270337-92a5uwjf	330	2	Diazepam	diazepam	NN
cord-270337-92a5uwjf	330	3	+	+	CC
cord-270337-92a5uwjf	330	4	adrenaline	adrenaline	NN
cord-270337-92a5uwjf	330	5	 	 	_SP