id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299424-qy3lccjq	MUBAGWA, Kanigula	Chloroquine cardiac effects and toxicity.A short update.	2020-06-19		.txt	text/plain	8955	464	41	-The mechanisms underlying cardiac chloroquine effects include direct actions on ion channels and receptors, while others involve an inhibition of autophagy. Functional changes in remodeled myocardium include modifications in the electrical properties (called electrical remodeling), as a result of altered expression of ion channels (e.g., Kir K + channels, L-type Ca 2+ channels, connexins, ryanodine receptors, etc.), transporters (e.g., Na + -Ca 2+ -and exchangers, sarcoplasmic reticulum ATPases, etc.) and other proteins, which impact on the action potential and its conduction within the cardiac tissue, on the excitation-contraction coupling, and on the contractile properties. I K-ATP inhibition in cardiac myocytes occurred at micromolar concentrations (IC 50 : 0.5 µM), indicating that chloroquine at therapeutic doses could also act on the heart through mechanisms involving ATP-sensitive channels, e.g. to antagonize fibrillation following action potential shortening and inhomogeneity during ischemia. The mechanisms underlying chloroquine effects include direct actions on ion channels and receptors, while others (especially a cardiomyopathy developing following long-term treatment) involve the inhibition of autophagy.	./cache/cord-299424-qy3lccjq.txt	./txt/cord-299424-qy3lccjq.txt