id author title date pages extension mime words sentences flesch summary cache txt cord-286610-woqb1t06 Choukér, Alexander COVID-19—The largest isolation study in history: the value of shared learnings from spaceflight analogs 2020-10-22 .txt text/plain 5591 238 30 Life science research for space exploration has a long history in using high-fidelity spaceflight analogs to better understand the effect of prolonged isolation and confinement on genes, molecules, cells, neural circuits, and physiological systems to behavior. Space agencies and their human research programs have a long history of seeking to understand the effects of isolation and confinement on astronaut health and performance. Here, we summarize the opportunities of spaceflight analogs to accelerate (1) the understanding of the neurobehavioral and immunological consequences of social isolation during the COVID-19 pandemic, and (2) the development of innovative and efficient treatment strategies to mitigate adverse behavioral conditions. For instance, the NASA sponsored project "Hybrid Training -A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions" combines physical exercise with an interactive virtual environment to enhance sensory augmentation and stimulate brain plasticity during prolonged isolation and confinement 64 . ./cache/cord-286610-woqb1t06.txt ./txt/cord-286610-woqb1t06.txt