id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252855-xtsnlu1f	Drago-Serrano, Maria Elisa	Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections	2017-03-01		.txt	text/plain	12045	481	30	In this review, we highlight recent findings in in vitro and in vivo models of the gut, lung, oral cavity, mammary gland, and liver infections that provide experimental evidence supporting the therapeutic role of human and bovine Lf in promoting some parameters of inflammation and protecting against the deleterious effects of bacterial, viral, fungal and protozoan-associated inflammation. However, this is not always the case because studies on intestinal epithelial-barrier function and mucosal inflammation carried out in a Caco-2 cells model and macrophages activated with lipopolysaccharide (LPS) showed that both Lf forms effectively inhibited the pro-inflammatory response. In a mice model of hepatitis induced by intraperitoneal co-administration of LPS and zymosan, orally administered bLf decreased the serum aspartate aminotransferase activity (a marker of liver inflammation), and increased in the small intestine the production of IL-11, an anti-inflammatory cytokine with a role in the amelioration of inflammatory response [153, 164] .	./cache/cord-252855-xtsnlu1f.txt	./txt/cord-252855-xtsnlu1f.txt