id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006192-bqwchhwk	Persson, Carl G. A.	Plasma exudation and asthma	1988		.txt	text/plain	7200	375	35	It is concluded that inflammatory stimulus-induced increase in macromolecular permeability of the tracheobronchial microvasculature and mucosa may be a significant pathogenetic mechanism in asthma and that the postcapillary venular endothelium and airway epithelium that regulate leakage of plasma are important effector cells in this disease. A role for plasma exudation in "dry-air-induced asthma" may be hypothesized for 2 main reasons: (1) in inflamed airways it is vessel fluid that humidifies incoming air whereas other sources are used under normal conditions [25, 45] ; (2) effective protection against this nonpharmacologic provocation is provided by drugs such as cromoglycate and glucocorticosteroids, which may have potent antileakage effects at airway endothelial-epithelial barriers [42, 107] . More recent ultrastructural, pathophysiological, and pharmacologic studies of systemic microvascular beds have shown that inflammatory mediatorinduced leakage of protein-rich plasma occurs in postcapillary venules (diameter 10-50 ~m) through large gaps (up to 1 tzm) between endothelial cells [23, 62, 64, 78, 89, 116, 122, 134, 145, 153] (Fig. 2 ).	./cache/cord-006192-bqwchhwk.txt	./txt/cord-006192-bqwchhwk.txt