id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-345922-3waid65i	Tiwari, Sneham	Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis	2018-09-11		.txt	text/plain	7796	387	38	Inset shows the ratio between genders and that women are twice as likely than men to develop MS Significance Despite major research efforts in the past few decades, the extent to which environmental factors (including external pathogens) and genetic susceptibility contribute to the pathogenesis of multiple sclerosis (MS) is not clearly identified. Even though different animal models of MS, such as the experimental autoimmune encephalitis (EAE) model and TMEV model aided in the understanding of possible underlying mechanisms including molecular mimicry and bystander activation, animal models for the most commonly associated viruses HHV-6 and EBV have yet to be developed (Virtanen & Jacobson, 2012) . B cell immunity plays an integral part in the development of MS because of its role in antibody presentation, cytokine production, meningeal inflammation, axonal degeneration, and grey matter F I G U R E 3 Schematic diagram of environmental factors and host derived pathways in causation of the disease and therapeutic strategies associated with multiple sclerosis (MS) progression.	./cache/cord-345922-3waid65i.txt	./txt/cord-345922-3waid65i.txt