id	sid	tid	token	lemma	pos
cord-277535-u283k70i	1	1	key	key	NN
cord-277535-u283k70i	1	2	:	:	:
cord-277535-u283k70i	2	1	cord-277535-u283k70i	cord-277535-u283k70i	JJ
cord-277535-u283k70i	2	2	authors	author	NNS
cord-277535-u283k70i	2	3	:	:	:
cord-277535-u283k70i	2	4	Vaja	Vaja	NNP
cord-277535-u283k70i	2	5	,	,	,
cord-277535-u283k70i	2	6	Rakesh	Rakesh	NNP
cord-277535-u283k70i	2	7	;	;	:
cord-277535-u283k70i	2	8	Rana	Rana	NNP
cord-277535-u283k70i	2	9	,	,	,
cord-277535-u283k70i	2	10	Meenal	Meenal	NNP
cord-277535-u283k70i	2	11	title	title	NN
cord-277535-u283k70i	2	12	:	:	:
cord-277535-u283k70i	2	13	Drugs	drug	NNS
cord-277535-u283k70i	2	14	and	and	CC
cord-277535-u283k70i	2	15	the	the	DT
cord-277535-u283k70i	2	16	liver	liver	NN
cord-277535-u283k70i	2	17	date	date	NN
cord-277535-u283k70i	2	18	:	:	:
cord-277535-u283k70i	2	19	2020	2020	CD
cord-277535-u283k70i	2	20	-	-	HYPH
cord-277535-u283k70i	2	21	09	09	CD
cord-277535-u283k70i	2	22	-	-	SYM
cord-277535-u283k70i	2	23	22	22	CD
cord-277535-u283k70i	2	24	journal	journal	NN
cord-277535-u283k70i	2	25	:	:	:
cord-277535-u283k70i	2	26	nan	nan	NNP
cord-277535-u283k70i	2	27	DOI	DOI	NNP
cord-277535-u283k70i	2	28	:	:	:
cord-277535-u283k70i	2	29	10.1016/	10.1016/	CD
cord-277535-u283k70i	3	1	j.mpaic.2020.07.001	j.mpaic.2020.07.001	NNP
cord-277535-u283k70i	3	2	sha	sha	NNP
cord-277535-u283k70i	3	3	:	:	:
cord-277535-u283k70i	3	4	76c266aedbe4bdbed2e120d7b967ff1fb16056cb	76c266aedbe4bdbed2e120d7b967ff1fb16056cb	CD
cord-277535-u283k70i	3	5	doc_id	doc_id	CD
cord-277535-u283k70i	3	6	:	:	:
cord-277535-u283k70i	3	7	277535	277535	CD
cord-277535-u283k70i	3	8	cord_uid	cord_uid	NNS
cord-277535-u283k70i	3	9	:	:	:
cord-277535-u283k70i	3	10	u283k70i	u283k70i	JJ
cord-277535-u283k70i	4	1	The	the	DT
cord-277535-u283k70i	4	2	liver	liver	NN
cord-277535-u283k70i	4	3	is	be	VBZ
cord-277535-u283k70i	4	4	a	a	DT
cord-277535-u283k70i	4	5	major	major	JJ
cord-277535-u283k70i	4	6	organ	organ	NN
cord-277535-u283k70i	4	7	with	with	IN
cord-277535-u283k70i	4	8	multiple	multiple	JJ
cord-277535-u283k70i	4	9	functions	function	NNS
cord-277535-u283k70i	4	10	.	.	.
cord-277535-u283k70i	5	1	A	a	DT
cord-277535-u283k70i	5	2	number	number	NN
cord-277535-u283k70i	5	3	of	of	IN
cord-277535-u283k70i	5	4	drugs	drug	NNS
cord-277535-u283k70i	5	5	are	be	VBP
cord-277535-u283k70i	5	6	metabolized	metabolize	VBN
cord-277535-u283k70i	5	7	by	by	IN
cord-277535-u283k70i	5	8	the	the	DT
cord-277535-u283k70i	5	9	liver	liver	NN
cord-277535-u283k70i	5	10	during	during	IN
cord-277535-u283k70i	5	11	phase	phase	NN
cord-277535-u283k70i	5	12	1	1	CD
cord-277535-u283k70i	5	13	and	and	CC
cord-277535-u283k70i	5	14	2	2	CD
cord-277535-u283k70i	5	15	reactions	reaction	NNS
cord-277535-u283k70i	5	16	which	which	WDT
cord-277535-u283k70i	5	17	include	include	VBP
cord-277535-u283k70i	5	18	complex	complex	JJ
cord-277535-u283k70i	5	19	processes	process	NNS
cord-277535-u283k70i	5	20	involving	involve	VBG
cord-277535-u283k70i	5	21	cytochrome	cytochrome	NN
cord-277535-u283k70i	5	22	P450	p450	JJ
cord-277535-u283k70i	5	23	enzymes	enzyme	NNS
cord-277535-u283k70i	5	24	.	.	.
cord-277535-u283k70i	6	1	Genetic	genetic	JJ
cord-277535-u283k70i	6	2	and	and	CC
cord-277535-u283k70i	6	3	acquired	acquire	VBD
cord-277535-u283k70i	6	4	variability	variability	NN
cord-277535-u283k70i	6	5	in	in	IN
cord-277535-u283k70i	6	6	cytochrome	cytochrome	NN
cord-277535-u283k70i	6	7	P450	p450	JJ
cord-277535-u283k70i	6	8	activity	activity	NN
cord-277535-u283k70i	6	9	may	may	MD
cord-277535-u283k70i	6	10	have	have	VB
cord-277535-u283k70i	6	11	profound	profound	JJ
cord-277535-u283k70i	6	12	effects	effect	NNS
cord-277535-u283k70i	6	13	on	on	IN
cord-277535-u283k70i	6	14	pharmacokinetics	pharmacokinetic	NNS
cord-277535-u283k70i	6	15	.	.	.
cord-277535-u283k70i	7	1	Additionally	additionally	RB
cord-277535-u283k70i	7	2	,	,	,
cord-277535-u283k70i	7	3	drugs	drug	NNS
cord-277535-u283k70i	7	4	can	can	MD
cord-277535-u283k70i	7	5	also	also	RB
cord-277535-u283k70i	7	6	modify	modify	VB
cord-277535-u283k70i	7	7	how	how	WRB
cord-277535-u283k70i	7	8	the	the	DT
cord-277535-u283k70i	7	9	liver	liver	NN
cord-277535-u283k70i	7	10	functions	function	NNS
cord-277535-u283k70i	7	11	and	and	CC
cord-277535-u283k70i	7	12	cause	cause	VB
cord-277535-u283k70i	7	13	dysfunction	dysfunction	NN
cord-277535-u283k70i	7	14	or	or	CC
cord-277535-u283k70i	7	15	even	even	RB
cord-277535-u283k70i	7	16	failure	failure	NN
cord-277535-u283k70i	7	17	of	of	IN
cord-277535-u283k70i	7	18	the	the	DT
cord-277535-u283k70i	7	19	organ	organ	NN
cord-277535-u283k70i	7	20	both	both	DT
cord-277535-u283k70i	7	21	by	by	IN
cord-277535-u283k70i	7	22	a	a	DT
cord-277535-u283k70i	7	23	direct	direct	JJ
cord-277535-u283k70i	7	24	effect	effect	NN
cord-277535-u283k70i	7	25	on	on	IN
cord-277535-u283k70i	7	26	the	the	DT
cord-277535-u283k70i	7	27	liver	liver	NN
cord-277535-u283k70i	7	28	or	or	CC
cord-277535-u283k70i	7	29	by	by	IN
cord-277535-u283k70i	7	30	alteration	alteration	NN
cord-277535-u283k70i	7	31	in	in	IN
cord-277535-u283k70i	7	32	liver	liver	NN
cord-277535-u283k70i	7	33	blood	blood	NN
cord-277535-u283k70i	7	34	flow	flow	NN
cord-277535-u283k70i	7	35	.	.	.
cord-277535-u283k70i	8	1	It	-PRON-	PRP
cord-277535-u283k70i	8	2	is	be	VBZ
cord-277535-u283k70i	8	3	important	important	JJ
cord-277535-u283k70i	8	4	to	to	TO
cord-277535-u283k70i	8	5	recognize	recognize	VB
cord-277535-u283k70i	8	6	the	the	DT
cord-277535-u283k70i	8	7	signs	sign	NNS
cord-277535-u283k70i	8	8	and	and	CC
cord-277535-u283k70i	8	9	symptoms	symptom	NNS
cord-277535-u283k70i	8	10	of	of	IN
cord-277535-u283k70i	8	11	liver	liver	NN
cord-277535-u283k70i	8	12	failure	failure	NN
cord-277535-u283k70i	8	13	in	in	IN
cord-277535-u283k70i	8	14	patients	patient	NNS
cord-277535-u283k70i	8	15	and	and	CC
cord-277535-u283k70i	8	16	identify	identify	VB
cord-277535-u283k70i	8	17	possible	possible	JJ
cord-277535-u283k70i	8	18	causes	cause	NNS
cord-277535-u283k70i	8	19	including	include	VBG
cord-277535-u283k70i	8	20	drug	drug	NN
cord-277535-u283k70i	8	21	interactions	interaction	NNS
cord-277535-u283k70i	8	22	.	.	.
cord-277535-u283k70i	9	1	Furthermore	furthermore	RB
cord-277535-u283k70i	9	2	,	,	,
cord-277535-u283k70i	9	3	once	once	RB
cord-277535-u283k70i	9	4	a	a	DT
cord-277535-u283k70i	9	5	patient	patient	NN
cord-277535-u283k70i	9	6	has	have	VBZ
cord-277535-u283k70i	9	7	been	be	VBN
cord-277535-u283k70i	9	8	recognized	recognize	VBN
cord-277535-u283k70i	9	9	to	to	TO
cord-277535-u283k70i	9	10	be	be	VB
cord-277535-u283k70i	9	11	suffering	suffer	VBG
cord-277535-u283k70i	9	12	with	with	IN
cord-277535-u283k70i	9	13	liver	liver	NN
cord-277535-u283k70i	9	14	dysfunction	dysfunction	NN
cord-277535-u283k70i	9	15	or	or	CC
cord-277535-u283k70i	9	16	failure	failure	NN
cord-277535-u283k70i	9	17	drug	drug	NN
cord-277535-u283k70i	9	18	choice	choice	NN
cord-277535-u283k70i	9	19	and	and	CC
cord-277535-u283k70i	9	20	dosing	dosing	NN
cord-277535-u283k70i	9	21	regime	regime	NN
cord-277535-u283k70i	9	22	will	will	MD
cord-277535-u283k70i	9	23	need	need	VB
cord-277535-u283k70i	9	24	to	to	TO
cord-277535-u283k70i	9	25	be	be	VB
cord-277535-u283k70i	9	26	rationalized	rationalize	VBN
cord-277535-u283k70i	9	27	.	.	.
cord-277535-u283k70i	10	1	Paracetamol	paracetamol	JJ
cord-277535-u283k70i	10	2	overdose	overdose	NN
cord-277535-u283k70i	10	3	can	can	MD
cord-277535-u283k70i	10	4	have	have	VB
cord-277535-u283k70i	10	5	severe	severe	JJ
cord-277535-u283k70i	10	6	and	and	CC
cord-277535-u283k70i	10	7	life	life	NN
cord-277535-u283k70i	10	8	threatening	threaten	VBG
cord-277535-u283k70i	10	9	consequences	consequence	NNS
cord-277535-u283k70i	10	10	for	for	IN
cord-277535-u283k70i	10	11	patients	patient	NNS
cord-277535-u283k70i	10	12	due	due	JJ
cord-277535-u283k70i	10	13	to	to	IN
cord-277535-u283k70i	10	14	its	-PRON-	PRP$
cord-277535-u283k70i	10	15	effect	effect	NN
cord-277535-u283k70i	10	16	on	on	IN
cord-277535-u283k70i	10	17	liver	liver	NN
cord-277535-u283k70i	10	18	function	function	NN
cord-277535-u283k70i	10	19	.	.	.
cord-277535-u283k70i	11	1	It	-PRON-	PRP
cord-277535-u283k70i	11	2	is	be	VBZ
cord-277535-u283k70i	11	3	the	the	DT
cord-277535-u283k70i	11	4	leading	leading	JJ
cord-277535-u283k70i	11	5	cause	cause	NN
cord-277535-u283k70i	11	6	of	of	IN
cord-277535-u283k70i	11	7	acute	acute	JJ
cord-277535-u283k70i	11	8	liver	liver	NN
cord-277535-u283k70i	11	9	failure	failure	NN
cord-277535-u283k70i	11	10	in	in	IN
cord-277535-u283k70i	11	11	the	the	DT
cord-277535-u283k70i	11	12	UK	UK	NNP
cord-277535-u283k70i	11	13	,	,	,
cord-277535-u283k70i	11	14	1	1	CD
cord-277535-u283k70i	11	15	Correct	correct	JJ
cord-277535-u283k70i	11	16	and	and	CC
cord-277535-u283k70i	11	17	early	early	JJ
cord-277535-u283k70i	11	18	management	management	NN
cord-277535-u283k70i	11	19	is	be	VBZ
cord-277535-u283k70i	11	20	crucial	crucial	JJ
cord-277535-u283k70i	11	21	and	and	CC
cord-277535-u283k70i	11	22	will	will	MD
cord-277535-u283k70i	11	23	be	be	VB
cord-277535-u283k70i	11	24	discussed	discuss	VBN
cord-277535-u283k70i	11	25	within	within	IN
cord-277535-u283k70i	11	26	this	this	DT
cord-277535-u283k70i	11	27	article	article	NN
cord-277535-u283k70i	11	28	.	.	.
cord-277535-u283k70i	12	1	The	the	DT
cord-277535-u283k70i	12	2	liver	liver	NN
cord-277535-u283k70i	12	3	receives	receive	VBZ
cord-277535-u283k70i	12	4	approximately	approximately	RB
cord-277535-u283k70i	12	5	30	30	CD
cord-277535-u283k70i	12	6	%	%	NN
cord-277535-u283k70i	12	7	of	of	IN
cord-277535-u283k70i	12	8	cardiac	cardiac	JJ
cord-277535-u283k70i	12	9	output	output	NN
cord-277535-u283k70i	12	10	.	.	.
cord-277535-u283k70i	13	1	Uniquely	uniquely	RB
cord-277535-u283k70i	13	2	it	-PRON-	PRP
cord-277535-u283k70i	13	3	receives	receive	VBZ
cord-277535-u283k70i	13	4	both	both	DT
cord-277535-u283k70i	13	5	arterial	arterial	JJ
cord-277535-u283k70i	13	6	blood	blood	NN
cord-277535-u283k70i	13	7	from	from	IN
cord-277535-u283k70i	13	8	the	the	DT
cord-277535-u283k70i	13	9	hepatic	hepatic	JJ
cord-277535-u283k70i	13	10	artery	artery	NN
cord-277535-u283k70i	13	11	and	and	CC
cord-277535-u283k70i	13	12	venous	venous	JJ
cord-277535-u283k70i	13	13	blood	blood	NN
cord-277535-u283k70i	13	14	from	from	IN
cord-277535-u283k70i	13	15	the	the	DT
cord-277535-u283k70i	13	16	portal	portal	JJ
cord-277535-u283k70i	13	17	veins	vein	NNS
cord-277535-u283k70i	13	18	.	.	.
cord-277535-u283k70i	14	1	The	the	DT
cord-277535-u283k70i	14	2	portal	portal	JJ
cord-277535-u283k70i	14	3	vein	vein	NN
cord-277535-u283k70i	14	4	supplies	supply	VBZ
cord-277535-u283k70i	14	5	70e75	70e75	CD
cord-277535-u283k70i	14	6	%	%	NN
cord-277535-u283k70i	14	7	of	of	IN
cord-277535-u283k70i	14	8	hepatic	hepatic	JJ
cord-277535-u283k70i	14	9	blood	blood	NN
cord-277535-u283k70i	14	10	flow	flow	NN
cord-277535-u283k70i	14	11	but	but	CC
cord-277535-u283k70i	14	12	only	only	RB
cord-277535-u283k70i	14	13	50	50	CD
cord-277535-u283k70i	14	14	%	%	NN
cord-277535-u283k70i	14	15	of	of	IN
cord-277535-u283k70i	14	16	oxygen	oxygen	NN
cord-277535-u283k70i	14	17	supply	supply	NN
cord-277535-u283k70i	14	18	,	,	,
cord-277535-u283k70i	14	19	the	the	DT
cord-277535-u283k70i	14	20	remaining	remain	VBG
cord-277535-u283k70i	14	21	blood	blood	NN
cord-277535-u283k70i	14	22	flow	flow	NN
cord-277535-u283k70i	14	23	and	and	CC
cord-277535-u283k70i	14	24	oxygen	oxygen	NN
cord-277535-u283k70i	14	25	supply	supply	NN
cord-277535-u283k70i	14	26	being	be	VBG
cord-277535-u283k70i	14	27	from	from	IN
cord-277535-u283k70i	14	28	the	the	DT
cord-277535-u283k70i	14	29	hepatic	hepatic	JJ
cord-277535-u283k70i	14	30	artery	artery	NN
cord-277535-u283k70i	14	31	.	.	.
cord-277535-u283k70i	15	1	Anatomically	anatomically	RB
cord-277535-u283k70i	15	2	the	the	DT
cord-277535-u283k70i	15	3	liver	liver	NN
cord-277535-u283k70i	15	4	is	be	VBZ
cord-277535-u283k70i	15	5	divided	divide	VBN
cord-277535-u283k70i	15	6	into	into	IN
cord-277535-u283k70i	15	7	two	two	CD
cord-277535-u283k70i	15	8	lobes	lobe	NNS
cord-277535-u283k70i	15	9	and	and	CC
cord-277535-u283k70i	15	10	further	far	RBR
cord-277535-u283k70i	15	11	into	into	IN
cord-277535-u283k70i	15	12	functional	functional	JJ
cord-277535-u283k70i	15	13	lobules	lobule	NNS
cord-277535-u283k70i	15	14	based	base	VBN
cord-277535-u283k70i	15	15	around	around	IN
cord-277535-u283k70i	15	16	a	a	DT
cord-277535-u283k70i	15	17	central	central	JJ
cord-277535-u283k70i	15	18	vein	vein	NN
cord-277535-u283k70i	15	19	,	,	,
cord-277535-u283k70i	15	20	which	which	WDT
cord-277535-u283k70i	15	21	contains	contain	VBZ
cord-277535-u283k70i	15	22	blood	blood	NN
cord-277535-u283k70i	15	23	from	from	IN
cord-277535-u283k70i	15	24	the	the	DT
cord-277535-u283k70i	15	25	hepatic	hepatic	JJ
cord-277535-u283k70i	15	26	arterial	arterial	NN
cord-277535-u283k70i	15	27	and	and	CC
cord-277535-u283k70i	15	28	portal	portal	JJ
cord-277535-u283k70i	15	29	venous	venous	JJ
cord-277535-u283k70i	15	30	circulations	circulation	NNS
cord-277535-u283k70i	15	31	.	.	.
cord-277535-u283k70i	16	1	Blood	blood	NN
cord-277535-u283k70i	16	2	arriving	arrive	VBG
cord-277535-u283k70i	16	3	to	to	IN
cord-277535-u283k70i	16	4	the	the	DT
cord-277535-u283k70i	16	5	liver	liver	NN
cord-277535-u283k70i	16	6	flows	flow	VBZ
cord-277535-u283k70i	16	7	into	into	IN
cord-277535-u283k70i	16	8	the	the	DT
cord-277535-u283k70i	16	9	sinusoids	sinusoid	NNS
cord-277535-u283k70i	16	10	which	which	WDT
cord-277535-u283k70i	16	11	are	be	VBP
cord-277535-u283k70i	16	12	spaces	space	NNS
cord-277535-u283k70i	16	13	lined	line	VBN
cord-277535-u283k70i	16	14	by	by	IN
cord-277535-u283k70i	16	15	hepactocytes	hepactocyte	NNS
cord-277535-u283k70i	16	16	.	.	.
cord-277535-u283k70i	17	1	Blood	blood	NN
cord-277535-u283k70i	17	2	then	then	RB
cord-277535-u283k70i	17	3	drains	drain	VBZ
cord-277535-u283k70i	17	4	towards	towards	IN
cord-277535-u283k70i	17	5	the	the	DT
cord-277535-u283k70i	17	6	centre	centre	NN
cord-277535-u283k70i	17	7	of	of	IN
cord-277535-u283k70i	17	8	the	the	DT
cord-277535-u283k70i	17	9	lobule	lobule	NN
cord-277535-u283k70i	17	10	and	and	CC
cord-277535-u283k70i	17	11	the	the	DT
cord-277535-u283k70i	17	12	central	central	JJ
cord-277535-u283k70i	17	13	vein	vein	NN
cord-277535-u283k70i	17	14	then	then	RB
cord-277535-u283k70i	17	15	hepatic	hepatic	JJ
cord-277535-u283k70i	17	16	vein	vein	NN
cord-277535-u283k70i	17	17	to	to	TO
cord-277535-u283k70i	17	18	return	return	VB
cord-277535-u283k70i	17	19	blood	blood	NN
cord-277535-u283k70i	17	20	back	back	RB
cord-277535-u283k70i	17	21	to	to	IN
cord-277535-u283k70i	17	22	the	the	DT
cord-277535-u283k70i	17	23	heart	heart	NN
cord-277535-u283k70i	17	24	via	via	IN
cord-277535-u283k70i	17	25	the	the	DT
cord-277535-u283k70i	17	26	inferior	inferior	JJ
cord-277535-u283k70i	17	27	vena	vena	FW
cord-277535-u283k70i	17	28	cava	cava	NN
cord-277535-u283k70i	17	29	.	.	.
cord-277535-u283k70i	18	1	It	-PRON-	PRP
cord-277535-u283k70i	18	2	is	be	VBZ
cord-277535-u283k70i	18	3	the	the	DT
cord-277535-u283k70i	18	4	portal	portal	JJ
cord-277535-u283k70i	18	5	veins	vein	NNS
cord-277535-u283k70i	18	6	taking	take	VBG
cord-277535-u283k70i	18	7	blood	blood	NN
cord-277535-u283k70i	18	8	directly	directly	RB
cord-277535-u283k70i	18	9	from	from	IN
cord-277535-u283k70i	18	10	the	the	DT
cord-277535-u283k70i	18	11	gut	gut	NN
cord-277535-u283k70i	18	12	to	to	IN
cord-277535-u283k70i	18	13	the	the	DT
cord-277535-u283k70i	18	14	liver	liver	NN
cord-277535-u283k70i	18	15	which	which	WDT
cord-277535-u283k70i	18	16	allows	allow	VBZ
cord-277535-u283k70i	18	17	for	for	IN
cord-277535-u283k70i	18	18	first	first	JJ
cord-277535-u283k70i	18	19	pass	pass	NN
cord-277535-u283k70i	18	20	metabolism	metabolism	NN
cord-277535-u283k70i	18	21	,	,	,
cord-277535-u283k70i	18	22	making	make	VBG
cord-277535-u283k70i	18	23	the	the	DT
cord-277535-u283k70i	18	24	liver	liver	NN
cord-277535-u283k70i	18	25	susceptible	susceptible	JJ
cord-277535-u283k70i	18	26	to	to	IN
cord-277535-u283k70i	18	27	ingested	ingested	JJ
cord-277535-u283k70i	18	28	drugs	drug	NNS
cord-277535-u283k70i	18	29	as	as	IN
cord-277535-u283k70i	18	30	they	-PRON-	PRP
cord-277535-u283k70i	18	31	are	be	VBP
cord-277535-u283k70i	18	32	absorbed	absorb	VBN
cord-277535-u283k70i	18	33	from	from	IN
cord-277535-u283k70i	18	34	the	the	DT
cord-277535-u283k70i	18	35	gastrointestinal	gastrointestinal	JJ
cord-277535-u283k70i	18	36	tract	tract	NN
cord-277535-u283k70i	18	37	and	and	CC
cord-277535-u283k70i	18	38	transported	transport	VBN
cord-277535-u283k70i	18	39	to	to	IN
cord-277535-u283k70i	18	40	the	the	DT
cord-277535-u283k70i	18	41	liver	liver	NN
cord-277535-u283k70i	18	42	.	.	.
cord-277535-u283k70i	19	1	The	the	DT
cord-277535-u283k70i	19	2	liver	liver	NN
cord-277535-u283k70i	19	3	has	have	VBZ
cord-277535-u283k70i	19	4	a	a	DT
cord-277535-u283k70i	19	5	broad	broad	JJ
cord-277535-u283k70i	19	6	range	range	NN
cord-277535-u283k70i	19	7	of	of	IN
cord-277535-u283k70i	19	8	functions	function	NNS
cord-277535-u283k70i	19	9	categorized	categorize	VBN
cord-277535-u283k70i	19	10	in	in	IN
cord-277535-u283k70i	19	11	Table	Table	NNP
cord-277535-u283k70i	19	12	1	1	CD
cord-277535-u283k70i	19	13	.	.	.
cord-277535-u283k70i	20	1	The	the	DT
cord-277535-u283k70i	20	2	liver	liver	NN
cord-277535-u283k70i	20	3	metabolises	metabolise	VBZ
cord-277535-u283k70i	20	4	a	a	DT
cord-277535-u283k70i	20	5	wide	wide	JJ
cord-277535-u283k70i	20	6	range	range	NN
cord-277535-u283k70i	20	7	of	of	IN
cord-277535-u283k70i	20	8	drugs	drug	NNS
cord-277535-u283k70i	20	9	the	the	DT
cord-277535-u283k70i	20	10	end	end	NN
cord-277535-u283k70i	20	11	result	result	NN
cord-277535-u283k70i	20	12	being	be	VBG
cord-277535-u283k70i	20	13	to	to	TO
cord-277535-u283k70i	20	14	produce	produce	VB
cord-277535-u283k70i	20	15	water	water	NN
cord-277535-u283k70i	20	16	soluble	soluble	JJ
cord-277535-u283k70i	20	17	compounds	compound	NNS
cord-277535-u283k70i	20	18	which	which	WDT
cord-277535-u283k70i	20	19	can	can	MD
cord-277535-u283k70i	20	20	be	be	VB
cord-277535-u283k70i	20	21	excreted	excrete	VBN
cord-277535-u283k70i	20	22	in	in	IN
cord-277535-u283k70i	20	23	the	the	DT
cord-277535-u283k70i	20	24	bile	bile	NN
cord-277535-u283k70i	20	25	.	.	.
cord-277535-u283k70i	21	1	This	this	DT
cord-277535-u283k70i	21	2	results	result	VBZ
cord-277535-u283k70i	21	3	from	from	IN
cord-277535-u283k70i	21	4	phase	phase	NN
cord-277535-u283k70i	21	5	1	1	CD
cord-277535-u283k70i	21	6	reactions	reaction	NNS
cord-277535-u283k70i	21	7	mediated	mediate	VBN
cord-277535-u283k70i	21	8	by	by	IN
cord-277535-u283k70i	21	9	cytochrome	cytochrome	NN
cord-277535-u283k70i	21	10	p450	p450	NN
cord-277535-u283k70i	21	11	including	include	VBG
cord-277535-u283k70i	21	12	oxidation	oxidation	NN
cord-277535-u283k70i	21	13	,	,	,
cord-277535-u283k70i	21	14	reduction	reduction	NN
cord-277535-u283k70i	21	15	and	and	CC
cord-277535-u283k70i	21	16	hydrolysis	hydrolysis	NN
cord-277535-u283k70i	21	17	reactions	reaction	NNS
cord-277535-u283k70i	21	18	.	.	.
cord-277535-u283k70i	22	1	This	this	DT
cord-277535-u283k70i	22	2	is	be	VBZ
cord-277535-u283k70i	22	3	followed	follow	VBN
cord-277535-u283k70i	22	4	by	by	IN
cord-277535-u283k70i	22	5	phase	phase	NN
cord-277535-u283k70i	22	6	2	2	CD
cord-277535-u283k70i	22	7	reactions	reaction	NNS
cord-277535-u283k70i	22	8	which	which	WDT
cord-277535-u283k70i	22	9	are	be	VBP
cord-277535-u283k70i	22	10	conjugative	conjugative	JJ
cord-277535-u283k70i	22	11	.	.	.
cord-277535-u283k70i	23	1	The	the	DT
cord-277535-u283k70i	23	2	cytochrome	cytochrome	NN
cord-277535-u283k70i	23	3	P450	p450	JJ
cord-277535-u283k70i	23	4	family	family	NN
cord-277535-u283k70i	23	5	are	be	VBP
cord-277535-u283k70i	23	6	a	a	DT
cord-277535-u283k70i	23	7	group	group	NN
cord-277535-u283k70i	23	8	of	of	IN
cord-277535-u283k70i	23	9	enzymes	enzyme	NNS
cord-277535-u283k70i	23	10	found	find	VBN
cord-277535-u283k70i	23	11	mainly	mainly	RB
cord-277535-u283k70i	23	12	in	in	IN
cord-277535-u283k70i	23	13	the	the	DT
cord-277535-u283k70i	23	14	liver	liver	NN
cord-277535-u283k70i	23	15	,	,	,
cord-277535-u283k70i	23	16	which	which	WDT
cord-277535-u283k70i	23	17	perform	perform	VBP
cord-277535-u283k70i	23	18	oxidation	oxidation	NN
cord-277535-u283k70i	23	19	and	and	CC
cord-277535-u283k70i	23	20	reduction	reduction	NN
cord-277535-u283k70i	23	21	reactions	reaction	NNS
cord-277535-u283k70i	23	22	(	(	-LRB-
cord-277535-u283k70i	23	23	phase	phase	NN
cord-277535-u283k70i	23	24	1	1	CD
cord-277535-u283k70i	23	25	)	)	-RRB-
cord-277535-u283k70i	23	26	using	use	VBG
cord-277535-u283k70i	23	27	iron	iron	NN
cord-277535-u283k70i	23	28	to	to	TO
cord-277535-u283k70i	23	29	enhance	enhance	VB
cord-277535-u283k70i	23	30	the	the	DT
cord-277535-u283k70i	23	31	water	water	NN
cord-277535-u283k70i	23	32	solubility	solubility	NN
cord-277535-u283k70i	23	33	of	of	IN
cord-277535-u283k70i	23	34	drugs	drug	NNS
cord-277535-u283k70i	23	35	to	to	TO
cord-277535-u283k70i	23	36	aid	aid	VB
cord-277535-u283k70i	23	37	excretion	excretion	NN
cord-277535-u283k70i	23	38	.	.	.
cord-277535-u283k70i	24	1	CYP450	cyp450	JJ
cord-277535-u283k70i	24	2	enzymes	enzyme	NNS
cord-277535-u283k70i	24	3	are	be	VBP
cord-277535-u283k70i	24	4	so	so	RB
cord-277535-u283k70i	24	5	named	name	VBN
cord-277535-u283k70i	24	6	as	as	IN
cord-277535-u283k70i	24	7	they	-PRON-	PRP
cord-277535-u283k70i	24	8	are	be	VBP
cord-277535-u283k70i	24	9	bound	bind	VBN
cord-277535-u283k70i	24	10	to	to	IN
cord-277535-u283k70i	24	11	membranes	membrane	NNS
cord-277535-u283k70i	24	12	within	within	IN
cord-277535-u283k70i	24	13	the	the	DT
cord-277535-u283k70i	24	14	cell	cell	NN
cord-277535-u283k70i	24	15	and	and	CC
cord-277535-u283k70i	24	16	contain	contain	VBP
cord-277535-u283k70i	24	17	a	a	DT
cord-277535-u283k70i	24	18	haem	haem	NN
cord-277535-u283k70i	24	19	pigment	pigment	NN
cord-277535-u283k70i	24	20	that	that	WDT
cord-277535-u283k70i	24	21	absorbs	absorb	VBZ
cord-277535-u283k70i	24	22	light	light	NN
cord-277535-u283k70i	24	23	at	at	IN
cord-277535-u283k70i	24	24	a	a	DT
cord-277535-u283k70i	24	25	wavelength	wavelength	NN
cord-277535-u283k70i	24	26	of	of	IN
cord-277535-u283k70i	24	27	450	450	CD
cord-277535-u283k70i	24	28	nm	nm	NN
cord-277535-u283k70i	24	29	when	when	WRB
cord-277535-u283k70i	24	30	exposed	expose	VBN
cord-277535-u283k70i	24	31	to	to	IN
cord-277535-u283k70i	24	32	carbon	carbon	NN
cord-277535-u283k70i	24	33	monoxide	monoxide	NN
cord-277535-u283k70i	24	34	.	.	.
cord-277535-u283k70i	25	1	After	after	IN
cord-277535-u283k70i	25	2	reading	read	VBG
cord-277535-u283k70i	25	3	this	this	DT
cord-277535-u283k70i	25	4	article	article	NN
cord-277535-u283k70i	25	5	you	-PRON-	PRP
cord-277535-u283k70i	25	6	should	should	MD
cord-277535-u283k70i	25	7	:	:	:
cord-277535-u283k70i	25	8	C	C	NNP
cord-277535-u283k70i	25	9	understand	understand	VB
cord-277535-u283k70i	25	10	the	the	DT
cord-277535-u283k70i	25	11	mechanisms	mechanism	NNS
cord-277535-u283k70i	25	12	of	of	IN
cord-277535-u283k70i	25	13	drug	drug	NN
cord-277535-u283k70i	25	14	metabolism	metabolism	NN
cord-277535-u283k70i	25	15	by	by	IN
cord-277535-u283k70i	25	16	the	the	DT
cord-277535-u283k70i	25	17	liver	liver	NN
cord-277535-u283k70i	25	18	C	C	NNP
cord-277535-u283k70i	25	19	have	have	VBP
cord-277535-u283k70i	25	20	an	an	DT
cord-277535-u283k70i	25	21	appreciation	appreciation	NN
cord-277535-u283k70i	25	22	of	of	IN
cord-277535-u283k70i	25	23	alterations	alteration	NNS
cord-277535-u283k70i	25	24	to	to	IN
cord-277535-u283k70i	25	25	drug	drug	NN
cord-277535-u283k70i	25	26	choice	choice	NN
cord-277535-u283k70i	25	27	and	and	CC
cord-277535-u283k70i	25	28	dosing	dose	VBG
cord-277535-u283k70i	25	29	regimens	regimen	NNS
cord-277535-u283k70i	25	30	in	in	IN
cord-277535-u283k70i	25	31	patients	patient	NNS
cord-277535-u283k70i	25	32	with	with	IN
cord-277535-u283k70i	25	33	liver	liver	NN
cord-277535-u283k70i	25	34	disease	disease	NN
cord-277535-u283k70i	25	35	due	due	IN
cord-277535-u283k70i	25	36	to	to	IN
cord-277535-u283k70i	25	37	their	-PRON-	PRP$
cord-277535-u283k70i	25	38	altered	alter	VBN
cord-277535-u283k70i	25	39	pharmacokinetics	pharmacokinetic	NNS
cord-277535-u283k70i	25	40	C	c	NN
cord-277535-u283k70i	26	1	know	know	VB
cord-277535-u283k70i	26	2	the	the	DT
cord-277535-u283k70i	26	3	management	management	NN
cord-277535-u283k70i	26	4	of	of	IN
cord-277535-u283k70i	26	5	a	a	DT
cord-277535-u283k70i	26	6	patient	patient	NN
cord-277535-u283k70i	26	7	with	with	IN
cord-277535-u283k70i	26	8	paracetamol	paracetamol	JJ
cord-277535-u283k70i	26	9	overdose	overdose	NN
cord-277535-u283k70i	27	1	There	there	EX
cord-277535-u283k70i	27	2	are	be	VBP
cord-277535-u283k70i	27	3	many	many	JJ
cord-277535-u283k70i	27	4	different	different	JJ
cord-277535-u283k70i	27	5	isoforms	isoform	NNS
cord-277535-u283k70i	27	6	of	of	IN
cord-277535-u283k70i	27	7	CYP450	cyp450	JJ
cord-277535-u283k70i	27	8	,	,	,
cord-277535-u283k70i	27	9	classified	classify	VBN
cord-277535-u283k70i	27	10	according	accord	VBG
cord-277535-u283k70i	27	11	to	to	IN
cord-277535-u283k70i	27	12	their	-PRON-	PRP$
cord-277535-u283k70i	27	13	amino	amino	NN
cord-277535-u283k70i	27	14	acid	acid	NN
cord-277535-u283k70i	27	15	sequencing	sequencing	NN
cord-277535-u283k70i	27	16	into	into	IN
cord-277535-u283k70i	27	17	families	family	NNS
cord-277535-u283k70i	27	18	,	,	,
cord-277535-u283k70i	27	19	subfamilies	subfamily	NNS
cord-277535-u283k70i	27	20	and	and	CC
cord-277535-u283k70i	27	21	individual	individual	JJ
cord-277535-u283k70i	27	22	genes	gene	NNS
cord-277535-u283k70i	27	23	.	.	.
cord-277535-u283k70i	28	1	Their	-PRON-	PRP$
cord-277535-u283k70i	28	2	importance	importance	NN
cord-277535-u283k70i	28	3	can	can	MD
cord-277535-u283k70i	28	4	be	be	VB
cord-277535-u283k70i	28	5	seen	see	VBN
cord-277535-u283k70i	28	6	in	in	IN
cord-277535-u283k70i	28	7	certain	certain	JJ
cord-277535-u283k70i	28	8	subgroups	subgroup	NNS
cord-277535-u283k70i	28	9	that	that	WDT
cord-277535-u283k70i	28	10	lack	lack	VBP
cord-277535-u283k70i	28	11	particular	particular	JJ
cord-277535-u283k70i	28	12	genes	gene	NNS
cord-277535-u283k70i	28	13	.	.	.
cord-277535-u283k70i	29	1	An	an	DT
cord-277535-u283k70i	29	2	example	example	NN
cord-277535-u283k70i	29	3	pertinent	pertinent	JJ
cord-277535-u283k70i	29	4	to	to	IN
cord-277535-u283k70i	29	5	anaesthesia	anaesthesia	NN
cord-277535-u283k70i	29	6	is	be	VBZ
cord-277535-u283k70i	29	7	deficiency	deficiency	NN
cord-277535-u283k70i	29	8	in	in	IN
cord-277535-u283k70i	29	9	CYP2D6	CYP2D6	NNP
cord-277535-u283k70i	29	10	which	which	WDT
cord-277535-u283k70i	29	11	metabolises	metabolise	VBZ
cord-277535-u283k70i	29	12	codeine	codeine	NN
cord-277535-u283k70i	29	13	to	to	IN
cord-277535-u283k70i	29	14	morphine	morphine	NN
cord-277535-u283k70i	29	15	,	,	,
cord-277535-u283k70i	29	16	these	these	DT
cord-277535-u283k70i	29	17	patients	patient	NNS
cord-277535-u283k70i	29	18	therefore	therefore	RB
cord-277535-u283k70i	29	19	find	find	VBP
cord-277535-u283k70i	29	20	codeine	codeine	NN
cord-277535-u283k70i	29	21	ineffective	ineffective	JJ
cord-277535-u283k70i	29	22	.	.	.
cord-277535-u283k70i	30	1	Conversely	conversely	RB
cord-277535-u283k70i	30	2	there	there	EX
cord-277535-u283k70i	30	3	is	be	VBZ
cord-277535-u283k70i	30	4	a	a	DT
cord-277535-u283k70i	30	5	small	small	JJ
cord-277535-u283k70i	30	6	subgroup	subgroup	NN
cord-277535-u283k70i	30	7	of	of	IN
cord-277535-u283k70i	30	8	people	people	NNS
cord-277535-u283k70i	30	9	of	of	IN
cord-277535-u283k70i	30	10	Saudi	saudi	JJ
cord-277535-u283k70i	30	11	Arabian	arabian	JJ
cord-277535-u283k70i	30	12	and	and	CC
cord-277535-u283k70i	30	13	Ethiopian	ethiopian	JJ
cord-277535-u283k70i	30	14	decent	decent	JJ
cord-277535-u283k70i	30	15	with	with	IN
cord-277535-u283k70i	30	16	very	very	RB
cord-277535-u283k70i	30	17	high	high	JJ
cord-277535-u283k70i	30	18	expression	expression	NN
cord-277535-u283k70i	30	19	of	of	IN
cord-277535-u283k70i	30	20	2D6	2d6	CD
cord-277535-u283k70i	30	21	who	who	WP
cord-277535-u283k70i	30	22	metabolize	metabolize	VBP
cord-277535-u283k70i	30	23	codeine	codeine	NN
cord-277535-u283k70i	30	24	into	into	IN
cord-277535-u283k70i	30	25	vast	vast	JJ
cord-277535-u283k70i	30	26	amounts	amount	NNS
cord-277535-u283k70i	30	27	of	of	IN
cord-277535-u283k70i	30	28	morphine	morphine	NN
cord-277535-u283k70i	30	29	.	.	.
cord-277535-u283k70i	31	1	Refer	refer	VB
cord-277535-u283k70i	31	2	to	to	IN
cord-277535-u283k70i	31	3	Table	table	NN
cord-277535-u283k70i	31	4	2	2	CD
cord-277535-u283k70i	31	5	for	for	IN
cord-277535-u283k70i	31	6	more	more	JJR
cord-277535-u283k70i	31	7	details	detail	NNS
cord-277535-u283k70i	31	8	.	.	.
cord-277535-u283k70i	32	1	An	an	DT
cord-277535-u283k70i	32	2	individual	individual	NN
cord-277535-u283k70i	32	3	more	more	RBR
cord-277535-u283k70i	32	4	detailed	detailed	JJ
cord-277535-u283k70i	32	5	breakdown	breakdown	NN
cord-277535-u283k70i	32	6	of	of	IN
cord-277535-u283k70i	32	7	CYP450	cyp450	JJ
cord-277535-u283k70i	32	8	genes	gene	NNS
cord-277535-u283k70i	32	9	is	be	VBZ
cord-277535-u283k70i	32	10	beyond	beyond	IN
cord-277535-u283k70i	32	11	the	the	DT
cord-277535-u283k70i	32	12	scope	scope	NN
cord-277535-u283k70i	32	13	of	of	IN
cord-277535-u283k70i	32	14	this	this	DT
cord-277535-u283k70i	32	15	article	article	NN
cord-277535-u283k70i	32	16	.	.	.
cord-277535-u283k70i	33	1	Some	some	DT
cord-277535-u283k70i	33	2	drugs	drug	NNS
cord-277535-u283k70i	33	3	can	can	MD
cord-277535-u283k70i	33	4	induce	induce	VB
cord-277535-u283k70i	33	5	or	or	CC
cord-277535-u283k70i	33	6	inhibit	inhibit	VB
cord-277535-u283k70i	33	7	CYP450	cyp450	JJ
cord-277535-u283k70i	33	8	enzymes	enzyme	NNS
cord-277535-u283k70i	33	9	which	which	WDT
cord-277535-u283k70i	33	10	have	have	VBP
cord-277535-u283k70i	33	11	the	the	DT
cord-277535-u283k70i	33	12	sequential	sequential	JJ
cord-277535-u283k70i	33	13	effect	effect	NN
cord-277535-u283k70i	33	14	on	on	IN
cord-277535-u283k70i	33	15	the	the	DT
cord-277535-u283k70i	33	16	metabolism	metabolism	NN
cord-277535-u283k70i	33	17	of	of	IN
cord-277535-u283k70i	33	18	other	other	JJ
cord-277535-u283k70i	33	19	drugs	drug	NNS
cord-277535-u283k70i	33	20	,	,	,
cord-277535-u283k70i	33	21	either	either	CC
cord-277535-u283k70i	33	22	increasing	increase	VBG
cord-277535-u283k70i	33	23	or	or	CC
cord-277535-u283k70i	33	24	reducing	reduce	VBG
cord-277535-u283k70i	33	25	it	-PRON-	PRP
cord-277535-u283k70i	33	26	respectively	respectively	RB
cord-277535-u283k70i	33	27	.	.	.
cord-277535-u283k70i	34	1	Possibly	possibly	RB
cord-277535-u283k70i	34	2	the	the	DT
cord-277535-u283k70i	34	3	most	most	RBS
cord-277535-u283k70i	34	4	important	important	JJ
cord-277535-u283k70i	34	5	example	example	NN
cord-277535-u283k70i	34	6	is	be	VBZ
cord-277535-u283k70i	34	7	CYP3A4	CYP3A4	NNP
cord-277535-u283k70i	34	8	which	which	WDT
cord-277535-u283k70i	34	9	metabolises	metabolise	VBZ
cord-277535-u283k70i	34	10	many	many	JJ
cord-277535-u283k70i	34	11	substrates	substrate	NNS
cord-277535-u283k70i	34	12	and	and	CC
cord-277535-u283k70i	34	13	is	be	VBZ
cord-277535-u283k70i	34	14	induced	induce	VBN
cord-277535-u283k70i	34	15	by	by	IN
cord-277535-u283k70i	34	16	rifampicin	rifampicin	NNS
cord-277535-u283k70i	34	17	,	,	,
cord-277535-u283k70i	34	18	carbamazepine	carbamazepine	NN
cord-277535-u283k70i	34	19	,	,	,
cord-277535-u283k70i	34	20	phenytonin	phenytonin	NNP
cord-277535-u283k70i	34	21	and	and	CC
cord-277535-u283k70i	34	22	dexamethasone	dexamethasone	NN
cord-277535-u283k70i	34	23	.	.	.
cord-277535-u283k70i	35	1	Of	of	IN
cord-277535-u283k70i	35	2	interest	interest	NN
cord-277535-u283k70i	35	3	to	to	IN
cord-277535-u283k70i	35	4	anaesthesia	anaesthesia	NN
cord-277535-u283k70i	35	5	this	this	DT
cord-277535-u283k70i	35	6	will	will	MD
cord-277535-u283k70i	35	7	increase	increase	VB
cord-277535-u283k70i	35	8	metabolism	metabolism	NN
cord-277535-u283k70i	35	9	of	of	IN
cord-277535-u283k70i	35	10	opioids	opioid	NNS
cord-277535-u283k70i	35	11	,	,	,
cord-277535-u283k70i	35	12	benzodiazepines	benzodiazepine	NNS
cord-277535-u283k70i	35	13	and	and	CC
cord-277535-u283k70i	35	14	local	local	JJ
cord-277535-u283k70i	35	15	anaesthetics	anaesthetic	NNS
cord-277535-u283k70i	35	16	.	.	.
cord-277535-u283k70i	36	1	Another	another	DT
cord-277535-u283k70i	36	2	well	well	RB
cord-277535-u283k70i	36	3	cited	cite	VBN
cord-277535-u283k70i	36	4	example	example	NN
cord-277535-u283k70i	36	5	is	be	VBZ
cord-277535-u283k70i	36	6	the	the	DT
cord-277535-u283k70i	36	7	increased	increase	VBN
cord-277535-u283k70i	36	8	metabolism	metabolism	NN
cord-277535-u283k70i	36	9	of	of	IN
cord-277535-u283k70i	36	10	the	the	DT
cord-277535-u283k70i	36	11	oral	oral	JJ
cord-277535-u283k70i	36	12	contraceptive	contraceptive	JJ
cord-277535-u283k70i	36	13	pill	pill	NN
cord-277535-u283k70i	36	14	and	and	CC
cord-277535-u283k70i	36	15	its	-PRON-	PRP$
cord-277535-u283k70i	36	16	reduction	reduction	NN
cord-277535-u283k70i	36	17	in	in	IN
cord-277535-u283k70i	36	18	efficacy	efficacy	NN
cord-277535-u283k70i	36	19	.	.	.
cord-277535-u283k70i	37	1	For	for	IN
cord-277535-u283k70i	37	2	a	a	DT
cord-277535-u283k70i	37	3	more	more	RBR
cord-277535-u283k70i	37	4	exhaustive	exhaustive	JJ
cord-277535-u283k70i	37	5	list	list	NN
cord-277535-u283k70i	37	6	of	of	IN
cord-277535-u283k70i	37	7	substrates	substrate	NNS
cord-277535-u283k70i	37	8	,	,	,
cord-277535-u283k70i	37	9	inducers	inducer	NNS
cord-277535-u283k70i	37	10	and	and	CC
cord-277535-u283k70i	37	11	inhibitors	inhibitor	NNS
cord-277535-u283k70i	37	12	see	see	VBP
cord-277535-u283k70i	37	13	Table	table	NN
cord-277535-u283k70i	37	14	3	3	CD
cord-277535-u283k70i	38	1	(	(	-LRB-
cord-277535-u283k70i	38	2	See	see	VB
cord-277535-u283k70i	38	3	Table	Table	NNP
cord-277535-u283k70i	38	4	4	4	CD
cord-277535-u283k70i	38	5	)	)	-RRB-
cord-277535-u283k70i	38	6	.	.	.
cord-277535-u283k70i	39	1	A	a	DT
cord-277535-u283k70i	39	2	number	number	NN
cord-277535-u283k70i	39	3	of	of	IN
cord-277535-u283k70i	39	4	non	non	JJ
cord-277535-u283k70i	39	5	-	-	JJ
cord-277535-u283k70i	39	6	cytochrome	cytochrome	JJ
cord-277535-u283k70i	39	7	p450	p450	NN
cord-277535-u283k70i	39	8	dependent	dependent	JJ
cord-277535-u283k70i	39	9	reactions	reaction	NNS
cord-277535-u283k70i	39	10	occur	occur	VBP
cord-277535-u283k70i	39	11	in	in	IN
cord-277535-u283k70i	39	12	the	the	DT
cord-277535-u283k70i	39	13	liver	liver	NN
cord-277535-u283k70i	39	14	eg	eg	IN
cord-277535-u283k70i	39	15	oxidation	oxidation	NN
cord-277535-u283k70i	39	16	of	of	IN
cord-277535-u283k70i	39	17	dopamine	dopamine	NN
cord-277535-u283k70i	39	18	and	and	CC
cord-277535-u283k70i	39	19	alcohol	alcohol	NN
cord-277535-u283k70i	39	20	and	and	CC
cord-277535-u283k70i	39	21	hydrolysis	hydrolysis	NN
cord-277535-u283k70i	39	22	of	of	IN
cord-277535-u283k70i	39	23	amides	amide	NNS
cord-277535-u283k70i	39	24	and	and	CC
cord-277535-u283k70i	39	25	esters	ester	NNS
cord-277535-u283k70i	39	26	(	(	-LRB-
cord-277535-u283k70i	39	27	eg	eg	IN
cord-277535-u283k70i	39	28	lignocaine	lignocaine	NNP
cord-277535-u283k70i	39	29	and	and	CC
cord-277535-u283k70i	39	30	pethidine	pethidine	NN
cord-277535-u283k70i	39	31	respectively	respectively	RB
cord-277535-u283k70i	39	32	)	)	-RRB-
cord-277535-u283k70i	39	33	.	.	.
cord-277535-u283k70i	40	1	A	a	DT
cord-277535-u283k70i	40	2	predominant	predominant	JJ
cord-277535-u283k70i	40	3	rise	rise	NN
cord-277535-u283k70i	40	4	in	in	IN
cord-277535-u283k70i	40	5	aspartate	aspartate	NN
cord-277535-u283k70i	40	6	aminotransferase	aminotransferase	NN
cord-277535-u283k70i	40	7	(	(	-LRB-
cord-277535-u283k70i	40	8	AST	AST	NNP
cord-277535-u283k70i	40	9	)	)	-RRB-
cord-277535-u283k70i	40	10	and	and	CC
cord-277535-u283k70i	40	11	alanine	alanine	JJ
cord-277535-u283k70i	40	12	aminotransferase	aminotransferase	NN
cord-277535-u283k70i	40	13	(	(	-LRB-
cord-277535-u283k70i	40	14	ALT	ALT	NNP
cord-277535-u283k70i	40	15	)	)	-RRB-
cord-277535-u283k70i	40	16	signals	signal	VBZ
cord-277535-u283k70i	40	17	hepatocellular	hepatocellular	JJ
cord-277535-u283k70i	40	18	injury	injury	NN
cord-277535-u283k70i	40	19	or	or	CC
cord-277535-u283k70i	40	20	death	death	NN
cord-277535-u283k70i	40	21	.	.	.
cord-277535-u283k70i	41	1	This	this	DT
cord-277535-u283k70i	41	2	can	can	MD
cord-277535-u283k70i	41	3	be	be	VB
cord-277535-u283k70i	41	4	caused	cause	VBN
cord-277535-u283k70i	41	5	by	by	IN
cord-277535-u283k70i	41	6	drug	drug	NN
cord-277535-u283k70i	41	7	reactions	reaction	NNS
cord-277535-u283k70i	41	8	or	or	CC
cord-277535-u283k70i	41	9	toxicity	toxicity	NN
cord-277535-u283k70i	41	10	(	(	-LRB-
cord-277535-u283k70i	41	11	e.g.	e.g.	IN
cord-277535-u283k70i	41	12	paracetamol	paracetamol	NNP
cord-277535-u283k70i	41	13	)	)	-RRB-
cord-277535-u283k70i	41	14	,	,	,
cord-277535-u283k70i	41	15	viral	viral	JJ
cord-277535-u283k70i	41	16	hepatitis	hepatitis	NN
cord-277535-u283k70i	41	17	,	,	,
cord-277535-u283k70i	41	18	autoimmune	autoimmune	JJ
cord-277535-u283k70i	41	19	hepatitis	hepatitis	NN
cord-277535-u283k70i	41	20	,	,	,
cord-277535-u283k70i	41	21	alcoholic	alcoholic	JJ
cord-277535-u283k70i	41	22	hepatitis	hepatitis	NN
cord-277535-u283k70i	41	23	,	,	,
cord-277535-u283k70i	41	24	ischaemic	ischaemic	JJ
cord-277535-u283k70i	41	25	hepatitis	hepatitis	NN
cord-277535-u283k70i	41	26	secondary	secondary	JJ
cord-277535-u283k70i	41	27	to	to	IN
cord-277535-u283k70i	41	28	profound	profound	JJ
cord-277535-u283k70i	41	29	hypotension	hypotension	NN
cord-277535-u283k70i	41	30	,	,	,
cord-277535-u283k70i	41	31	and	and	CC
cord-277535-u283k70i	41	32	rare	rare	JJ
cord-277535-u283k70i	41	33	causes	cause	NNS
cord-277535-u283k70i	41	34	such	such	JJ
cord-277535-u283k70i	41	35	as	as	IN
cord-277535-u283k70i	41	36	Wilson	Wilson	NNP
cord-277535-u283k70i	41	37	's	's	POS
cord-277535-u283k70i	41	38	disease	disease	NN
cord-277535-u283k70i	41	39	.	.	.
cord-277535-u283k70i	42	1	An	an	DT
cord-277535-u283k70i	42	2	obstructive	obstructive	JJ
cord-277535-u283k70i	42	3	pattern	pattern	NN
cord-277535-u283k70i	42	4	has	have	VBZ
cord-277535-u283k70i	42	5	a	a	DT
cord-277535-u283k70i	42	6	rise	rise	NN
cord-277535-u283k70i	42	7	predominantly	predominantly	RB
cord-277535-u283k70i	42	8	in	in	IN
cord-277535-u283k70i	42	9	alkaline	alkaline	JJ
cord-277535-u283k70i	42	10	phosphatase	phosphatase	NN
cord-277535-u283k70i	42	11	(	(	-LRB-
cord-277535-u283k70i	42	12	ALP	ALP	NNP
cord-277535-u283k70i	42	13	)	)	-RRB-
cord-277535-u283k70i	42	14	and	and	CC
cord-277535-u283k70i	42	15	gamma	gamma	NN
cord-277535-u283k70i	42	16	-	-	HYPH
cord-277535-u283k70i	42	17	glutamyltransferase	glutamyltransferase	JJ
cord-277535-u283k70i	42	18	(	(	-LRB-
cord-277535-u283k70i	42	19	GGT	GGT	NNP
cord-277535-u283k70i	42	20	)	)	-RRB-
cord-277535-u283k70i	42	21	,	,	,
cord-277535-u283k70i	42	22	these	these	DT
cord-277535-u283k70i	42	23	are	be	VBP
cord-277535-u283k70i	42	24	canalicular	canalicular	JJ
cord-277535-u283k70i	42	25	enzymes	enzyme	NNS
cord-277535-u283k70i	42	26	and	and	CC
cord-277535-u283k70i	42	27	suggest	suggest	VBP
cord-277535-u283k70i	42	28	cholestasis	cholestasis	NN
cord-277535-u283k70i	42	29	.	.	.
cord-277535-u283k70i	43	1	This	this	DT
cord-277535-u283k70i	43	2	is	be	VBZ
cord-277535-u283k70i	43	3	caused	cause	VBN
cord-277535-u283k70i	43	4	by	by	IN
cord-277535-u283k70i	43	5	obstruction	obstruction	NN
cord-277535-u283k70i	43	6	,	,	,
cord-277535-u283k70i	43	7	either	either	CC
cord-277535-u283k70i	43	8	calculi	calculus	NNS
cord-277535-u283k70i	43	9	or	or	CC
cord-277535-u283k70i	43	10	tumour	tumour	NN
cord-277535-u283k70i	43	11	(	(	-LRB-
cord-277535-u283k70i	43	12	primary	primary	JJ
cord-277535-u283k70i	43	13	biliary	biliary	NN
cord-277535-u283k70i	43	14	,	,	,
cord-277535-u283k70i	43	15	pancreatic	pancreatic	NN
cord-277535-u283k70i	43	16	or	or	CC
cord-277535-u283k70i	43	17	metastases	metastasis	NNS
cord-277535-u283k70i	43	18	)	)	-RRB-
cord-277535-u283k70i	43	19	,	,	,
cord-277535-u283k70i	43	20	and	and	CC
cord-277535-u283k70i	43	21	liver	liver	NN
cord-277535-u283k70i	43	22	disease	disease	NN
cord-277535-u283k70i	43	23	such	such	JJ
cord-277535-u283k70i	43	24	as	as	IN
cord-277535-u283k70i	43	25	primary	primary	JJ
cord-277535-u283k70i	43	26	biliary	biliary	JJ
cord-277535-u283k70i	43	27	cirrhosis	cirrhosis	NN
cord-277535-u283k70i	43	28	.	.	.
cord-277535-u283k70i	44	1	Pharmacological	pharmacological	JJ
cord-277535-u283k70i	44	2	causes	cause	NNS
cord-277535-u283k70i	44	3	include	include	VBP
cord-277535-u283k70i	44	4	antibiotics	antibiotic	NNS
cord-277535-u283k70i	44	5	,	,	,
cord-277535-u283k70i	44	6	anabolic	anabolic	JJ
cord-277535-u283k70i	44	7	steroids	steroid	NNS
cord-277535-u283k70i	44	8	and	and	CC
cord-277535-u283k70i	44	9	oral	oral	JJ
cord-277535-u283k70i	44	10	contraceptives	contraceptive	NNS
cord-277535-u283k70i	44	11	.	.	.
cord-277535-u283k70i	45	1	A	a	DT
cord-277535-u283k70i	45	2	mixed	mixed	JJ
cord-277535-u283k70i	45	3	pattern	pattern	NN
cord-277535-u283k70i	45	4	can	can	MD
cord-277535-u283k70i	45	5	be	be	VB
cord-277535-u283k70i	45	6	seen	see	VBN
cord-277535-u283k70i	45	7	in	in	IN
cord-277535-u283k70i	45	8	sepsis	sepsis	NN
cord-277535-u283k70i	45	9	,	,	,
cord-277535-u283k70i	45	10	some	some	DT
cord-277535-u283k70i	45	11	drug	drug	NN
cord-277535-u283k70i	45	12	reactions	reaction	NNS
cord-277535-u283k70i	45	13	,	,	,
cord-277535-u283k70i	45	14	cholangitis	cholangitis	NN
cord-277535-u283k70i	45	15	,	,	,
cord-277535-u283k70i	45	16	congestive	congestive	JJ
cord-277535-u283k70i	45	17	cardiac	cardiac	JJ
cord-277535-u283k70i	45	18	failure	failure	NN
cord-277535-u283k70i	45	19	and	and	CC
cord-277535-u283k70i	45	20	alcoholic	alcoholic	JJ
cord-277535-u283k70i	45	21	liver	liver	NN
cord-277535-u283k70i	45	22	disease	disease	NN
cord-277535-u283k70i	45	23	.	.	.
cord-277535-u283k70i	46	1	Halothane	Halothane	NNP
cord-277535-u283k70i	46	2	hepatitis	hepatitis	NN
cord-277535-u283k70i	46	3	can	can	MD
cord-277535-u283k70i	46	4	cause	cause	VB
cord-277535-u283k70i	46	5	raised	raise	VBN
cord-277535-u283k70i	46	6	liver	liver	NN
cord-277535-u283k70i	46	7	enzyme	enzyme	NN
cord-277535-u283k70i	46	8	assays	assay	NNS
cord-277535-u283k70i	46	9	,	,	,
cord-277535-u283k70i	46	10	raised	raise	VBD
cord-277535-u283k70i	46	11	bilirubin	bilirubin	NN
cord-277535-u283k70i	46	12	and	and	CC
cord-277535-u283k70i	46	13	jaundice	jaundice	NN
cord-277535-u283k70i	46	14	.	.	.
cord-277535-u283k70i	47	1	An	an	DT
cord-277535-u283k70i	47	2	isolated	isolated	JJ
cord-277535-u283k70i	47	3	rise	rise	NN
cord-277535-u283k70i	47	4	in	in	IN
cord-277535-u283k70i	47	5	unconjugated	unconjugated	JJ
cord-277535-u283k70i	47	6	bilirubin	bilirubin	NN
cord-277535-u283k70i	47	7	may	may	MD
cord-277535-u283k70i	47	8	be	be	VB
cord-277535-u283k70i	47	9	attributed	attribute	VBN
cord-277535-u283k70i	47	10	to	to	IN
cord-277535-u283k70i	47	11	Gilbert	Gilbert	NNP
cord-277535-u283k70i	47	12	's	's	POS
cord-277535-u283k70i	47	13	syndrome	syndrome	NN
cord-277535-u283k70i	47	14	or	or	CC
cord-277535-u283k70i	47	15	haemolysis	haemolysis	NN
cord-277535-u283k70i	47	16	.	.	.
cord-277535-u283k70i	48	1	The	the	DT
cord-277535-u283k70i	48	2	SARS	SARS	NNP
cord-277535-u283k70i	48	3	-	-	HYPH
cord-277535-u283k70i	48	4	CoV-2	CoV-2	NNP
cord-277535-u283k70i	48	5	virus	virus	NN
cord-277535-u283k70i	48	6	uses	use	VBZ
cord-277535-u283k70i	48	7	angiotensin	angiotensin	NN
cord-277535-u283k70i	48	8	-	-	HYPH
cord-277535-u283k70i	48	9	converting	convert	VBG
cord-277535-u283k70i	48	10	enzyme	enzyme	NN
cord-277535-u283k70i	48	11	2(ACE-2	2(ace-2	CD
cord-277535-u283k70i	48	12	)	)	-RRB-
cord-277535-u283k70i	48	13	receptors	receptor	NNS
cord-277535-u283k70i	48	14	to	to	TO
cord-277535-u283k70i	48	15	gain	gain	VB
cord-277535-u283k70i	48	16	entry	entry	NN
cord-277535-u283k70i	48	17	into	into	IN
cord-277535-u283k70i	48	18	cells	cell	NNS
cord-277535-u283k70i	48	19	.	.	.
cord-277535-u283k70i	49	1	3	3	LS
cord-277535-u283k70i	49	2	Liver	liver	NN
cord-277535-u283k70i	49	3	particularly	particularly	RB
cord-277535-u283k70i	49	4	in	in	IN
cord-277535-u283k70i	49	5	the	the	DT
cord-277535-u283k70i	49	6	ductal	ductal	JJ
cord-277535-u283k70i	49	7	region	region	NN
cord-277535-u283k70i	49	8	has	have	VBZ
cord-277535-u283k70i	49	9	abundance	abundance	NN
cord-277535-u283k70i	49	10	of	of	IN
cord-277535-u283k70i	49	11	these	these	DT
cord-277535-u283k70i	49	12	receptors	receptor	NNS
cord-277535-u283k70i	49	13	,	,	,
cord-277535-u283k70i	49	14	hence	hence	RB
cord-277535-u283k70i	49	15	may	may	MD
cord-277535-u283k70i	49	16	be	be	VB
cord-277535-u283k70i	49	17	susceptible	susceptible	JJ
cord-277535-u283k70i	49	18	to	to	IN
cord-277535-u283k70i	49	19	SARS	SARS	NNP
cord-277535-u283k70i	49	20	-	-	HYPH
cord-277535-u283k70i	49	21	CoV-2	CoV-2	NNP
cord-277535-u283k70i	49	22	3	3	CD
cord-277535-u283k70i	49	23	Elevated	elevated	JJ
cord-277535-u283k70i	49	24	LFT	LFT	NNP
cord-277535-u283k70i	49	25	have	have	VBP
cord-277535-u283k70i	49	26	been	be	VBN
cord-277535-u283k70i	49	27	reported	report	VBN
cord-277535-u283k70i	49	28	widely	widely	RB
cord-277535-u283k70i	49	29	in	in	IN
cord-277535-u283k70i	49	30	hospitalized	hospitalize	VBN
cord-277535-u283k70i	49	31	patients	patient	NNS
cord-277535-u283k70i	49	32	with	with	IN
cord-277535-u283k70i	49	33	COVID-19	COVID-19	NNP
cord-277535-u283k70i	49	34	,	,	,
cord-277535-u283k70i	49	35	the	the	DT
cord-277535-u283k70i	49	36	range	range	NN
cord-277535-u283k70i	49	37	of	of	IN
cord-277535-u283k70i	49	38	elevation	elevation	NN
cord-277535-u283k70i	49	39	is	be	VBZ
cord-277535-u283k70i	49	40	highly	highly	RB
cord-277535-u283k70i	49	41	variable	variable	JJ
cord-277535-u283k70i	49	42	from	from	IN
cord-277535-u283k70i	49	43	14	14	CD
cord-277535-u283k70i	49	44	to	to	TO
cord-277535-u283k70i	49	45	58	58	CD
cord-277535-u283k70i	49	46	%	%	NN
cord-277535-u283k70i	49	47	.	.	.
cord-277535-u283k70i	50	1	4	4	LS
cord-277535-u283k70i	51	1	Surprisingly	surprisingly	RB
cord-277535-u283k70i	51	2	,	,	,
cord-277535-u283k70i	51	3	the	the	DT
cord-277535-u283k70i	51	4	pattern	pattern	NN
cord-277535-u283k70i	51	5	of	of	IN
cord-277535-u283k70i	51	6	elevation	elevation	NN
cord-277535-u283k70i	51	7	mimics	mimic	VBZ
cord-277535-u283k70i	51	8	hepatocyte	hepatocyte	NN
cord-277535-u283k70i	51	9	damage	damage	NN
cord-277535-u283k70i	51	10	(	(	-LRB-
cord-277535-u283k70i	51	11	AST	AST	NNP
cord-277535-u283k70i	51	12	/	/	SYM
cord-277535-u283k70i	51	13	ALT	alt	NN
cord-277535-u283k70i	51	14	higher	high	JJR
cord-277535-u283k70i	51	15	than	than	IN
cord-277535-u283k70i	51	16	bilirubin	bilirubin	NN
cord-277535-u283k70i	51	17	or	or	CC
cord-277535-u283k70i	51	18	ALP	ALP	NNP
cord-277535-u283k70i	51	19	)	)	-RRB-
cord-277535-u283k70i	51	20	rather	rather	RB
cord-277535-u283k70i	51	21	than	than	IN
cord-277535-u283k70i	51	22	cholangiocytic	cholangiocytic	JJ
cord-277535-u283k70i	51	23	damage	damage	NN
cord-277535-u283k70i	51	24	,	,	,
cord-277535-u283k70i	51	25	as	as	IN
cord-277535-u283k70i	51	26	would	would	MD
cord-277535-u283k70i	51	27	have	have	VB
cord-277535-u283k70i	51	28	been	be	VBN
cord-277535-u283k70i	51	29	expected	expect	VBN
cord-277535-u283k70i	51	30	given	give	VBN
cord-277535-u283k70i	51	31	the	the	DT
cord-277535-u283k70i	51	32	density	density	NN
cord-277535-u283k70i	51	33	of	of	IN
cord-277535-u283k70i	51	34	ACE-2	ACE-2	NNP
cord-277535-u283k70i	51	35	receptors	receptor	NNS
cord-277535-u283k70i	51	36	is	be	VBZ
cord-277535-u283k70i	51	37	higher	high	JJR
cord-277535-u283k70i	51	38	in	in	IN
cord-277535-u283k70i	51	39	the	the	DT
cord-277535-u283k70i	51	40	ductal	ductal	JJ
cord-277535-u283k70i	51	41	system	system	NN
cord-277535-u283k70i	51	42	.	.	.
cord-277535-u283k70i	52	1	4	4	LS
cord-277535-u283k70i	53	1	Additionally	additionally	RB
cord-277535-u283k70i	53	2	low	low	JJ
cord-277535-u283k70i	53	3	albumin	albumin	NN
cord-277535-u283k70i	53	4	has	have	VBZ
cord-277535-u283k70i	53	5	been	be	VBN
cord-277535-u283k70i	53	6	seen	see	VBN
cord-277535-u283k70i	53	7	and	and	CC
cord-277535-u283k70i	53	8	is	be	VBZ
cord-277535-u283k70i	53	9	a	a	DT
cord-277535-u283k70i	53	10	marker	marker	NN
cord-277535-u283k70i	53	11	of	of	IN
cord-277535-u283k70i	53	12	severe	severe	JJ
cord-277535-u283k70i	53	13	disease	disease	NN
cord-277535-u283k70i	53	14	.	.	.
cord-277535-u283k70i	54	1	5	5	LS
cord-277535-u283k70i	55	1	One	one	CD
cord-277535-u283k70i	55	2	study	study	NN
cord-277535-u283k70i	55	3	reported	report	VBD
cord-277535-u283k70i	55	4	longer	long	JJR
cord-277535-u283k70i	55	5	hospital	hospital	NN
cord-277535-u283k70i	55	6	stay	stay	NN
cord-277535-u283k70i	55	7	in	in	IN
cord-277535-u283k70i	55	8	patients	patient	NNS
cord-277535-u283k70i	55	9	with	with	IN
cord-277535-u283k70i	55	10	elevated	elevated	JJ
cord-277535-u283k70i	55	11	LFT	lft	NN
cord-277535-u283k70i	55	12	.	.	.
cord-277535-u283k70i	56	1	6	6	CD
cord-277535-u283k70i	57	1	An	an	DT
cord-277535-u283k70i	57	2	international	international	JJ
cord-277535-u283k70i	57	3	registry	registry	NN
cord-277535-u283k70i	57	4	has	have	VBZ
cord-277535-u283k70i	57	5	suggested	suggest	VBN
cord-277535-u283k70i	57	6	that	that	WDT
cord-277535-u283k70i	57	7	has	have	VBZ
cord-277535-u283k70i	57	8	many	many	JJ
cord-277535-u283k70i	57	9	as	as	IN
cord-277535-u283k70i	57	10	25	25	CD
cord-277535-u283k70i	57	11	%	%	NN
cord-277535-u283k70i	57	12	of	of	IN
cord-277535-u283k70i	57	13	patients	patient	NNS
cord-277535-u283k70i	57	14	with	with	IN
cord-277535-u283k70i	57	15	COVID-19	COVID-19	NNP
cord-277535-u283k70i	57	16	may	may	MD
cord-277535-u283k70i	57	17	present	present	VB
cord-277535-u283k70i	57	18	with	with	IN
cord-277535-u283k70i	57	19	hepatic	hepatic	JJ
cord-277535-u283k70i	57	20	decompensation	decompensation	NN
cord-277535-u283k70i	57	21	in	in	IN
cord-277535-u283k70i	57	22	absence	absence	NN
cord-277535-u283k70i	57	23	of	of	IN
cord-277535-u283k70i	57	24	respiratory	respiratory	JJ
cord-277535-u283k70i	57	25	symptoms	symptom	NNS
cord-277535-u283k70i	57	26	.	.	.
cord-277535-u283k70i	58	1	7	7	CD
cord-277535-u283k70i	59	1	The	the	DT
cord-277535-u283k70i	59	2	above	above	JJ
cord-277535-u283k70i	59	3	findings	finding	NNS
cord-277535-u283k70i	59	4	hold	hold	VBP
cord-277535-u283k70i	59	5	important	important	JJ
cord-277535-u283k70i	59	6	implications	implication	NNS
cord-277535-u283k70i	59	7	for	for	IN
cord-277535-u283k70i	59	8	anaesthetists	anaesthetist	NNS
cord-277535-u283k70i	59	9	,	,	,
cord-277535-u283k70i	59	10	especially	especially	RB
cord-277535-u283k70i	59	11	in	in	IN
cord-277535-u283k70i	59	12	preop	preop	JJ
cord-277535-u283k70i	59	13	assessments	assessment	NNS
cord-277535-u283k70i	59	14	.	.	.
cord-277535-u283k70i	60	1	Most	Most	JJS
cord-277535-u283k70i	60	2	drugs	drug	NNS
cord-277535-u283k70i	60	3	given	give	VBN
cord-277535-u283k70i	60	4	in	in	IN
cord-277535-u283k70i	60	5	anaesthesia	anaesthesia	NN
cord-277535-u283k70i	60	6	and	and	CC
cord-277535-u283k70i	60	7	intensive	intensive	JJ
cord-277535-u283k70i	60	8	care	care	NN
cord-277535-u283k70i	60	9	are	be	VBP
cord-277535-u283k70i	60	10	given	give	VBN
cord-277535-u283k70i	60	11	intravenously	intravenously	RB
cord-277535-u283k70i	60	12	,	,	,
cord-277535-u283k70i	60	13	thus	thus	RB
cord-277535-u283k70i	60	14	having	have	VBG
cord-277535-u283k70i	60	15	a	a	DT
cord-277535-u283k70i	60	16	bioavailability	bioavailability	NN
cord-277535-u283k70i	60	17	of	of	IN
cord-277535-u283k70i	60	18	1	1	CD
cord-277535-u283k70i	60	19	.	.	.
cord-277535-u283k70i	61	1	However	however	RB
cord-277535-u283k70i	61	2	some	some	DT
cord-277535-u283k70i	61	3	maybe	maybe	RB
cord-277535-u283k70i	61	4	given	give	VBN
cord-277535-u283k70i	61	5	orally	orally	RB
cord-277535-u283k70i	61	6	or	or	CC
cord-277535-u283k70i	61	7	nasogastrically	nasogastrically	RB
cord-277535-u283k70i	61	8	and	and	CC
cord-277535-u283k70i	61	9	absorbed	absorb	VBN
cord-277535-u283k70i	61	10	enterally	enterally	RB
cord-277535-u283k70i	61	11	.	.	.
cord-277535-u283k70i	62	1	The	the	DT
cord-277535-u283k70i	62	2	absorption	absorption	NN
cord-277535-u283k70i	62	3	will	will	MD
cord-277535-u283k70i	62	4	be	be	VB
cord-277535-u283k70i	62	5	affected	affect	VBN
cord-277535-u283k70i	62	6	by	by	IN
cord-277535-u283k70i	62	7	delayed	delay	VBN
cord-277535-u283k70i	62	8	gastric	gastric	JJ
cord-277535-u283k70i	62	9	emptying	emptying	NN
cord-277535-u283k70i	62	10	or	or	CC
cord-277535-u283k70i	62	11	reduced	reduce	VBN
cord-277535-u283k70i	62	12	by	by	IN
cord-277535-u283k70i	62	13	diarrhoea	diarrhoea	NN
cord-277535-u283k70i	62	14	and	and	CC
cord-277535-u283k70i	62	15	increased	increase	VBD
cord-277535-u283k70i	62	16	gastric	gastric	JJ
cord-277535-u283k70i	62	17	transit	transit	NN
cord-277535-u283k70i	62	18	time	time	NN
cord-277535-u283k70i	62	19	seen	see	VBN
cord-277535-u283k70i	62	20	in	in	IN
cord-277535-u283k70i	62	21	liver	liver	NN
cord-277535-u283k70i	62	22	failure	failure	NN
cord-277535-u283k70i	62	23	.	.	.
cord-277535-u283k70i	63	1	Additionally	additionally	RB
cord-277535-u283k70i	63	2	if	if	IN
cord-277535-u283k70i	63	3	vasopressors	vasopressor	NNS
cord-277535-u283k70i	63	4	are	be	VBP
cord-277535-u283k70i	63	5	used	use	VBN
cord-277535-u283k70i	63	6	there	there	RB
cord-277535-u283k70i	63	7	maybe	maybe	RB
cord-277535-u283k70i	63	8	splanchnic	splanchnic	JJ
cord-277535-u283k70i	63	9	vasoconstriction	vasoconstriction	NN
cord-277535-u283k70i	63	10	with	with	IN
cord-277535-u283k70i	63	11	associated	associated	JJ
cord-277535-u283k70i	63	12	reduced	reduce	VBN
cord-277535-u283k70i	63	13	absorption	absorption	NN
cord-277535-u283k70i	63	14	.	.	.
cord-277535-u283k70i	64	1	Volume	volume	NN
cord-277535-u283k70i	64	2	of	of	IN
cord-277535-u283k70i	64	3	distribution	distribution	NN
cord-277535-u283k70i	64	4	is	be	VBZ
cord-277535-u283k70i	64	5	a	a	DT
cord-277535-u283k70i	64	6	theoretical	theoretical	JJ
cord-277535-u283k70i	64	7	calculated	calculate	VBN
cord-277535-u283k70i	64	8	volume	volume	NN
cord-277535-u283k70i	64	9	within	within	IN
cord-277535-u283k70i	64	10	which	which	WDT
cord-277535-u283k70i	64	11	a	a	DT
cord-277535-u283k70i	64	12	dose	dose	NN
cord-277535-u283k70i	64	13	of	of	IN
cord-277535-u283k70i	64	14	a	a	DT
cord-277535-u283k70i	64	15	drug	drug	NN
cord-277535-u283k70i	64	16	is	be	VBZ
cord-277535-u283k70i	64	17	dissolved	dissolve	VBN
cord-277535-u283k70i	64	18	.	.	.
cord-277535-u283k70i	65	1	Hepatic	hepatic	JJ
cord-277535-u283k70i	65	2	dysfunction	dysfunction	NN
cord-277535-u283k70i	65	3	can	can	MD
cord-277535-u283k70i	65	4	cause	cause	VB
cord-277535-u283k70i	65	5	fluid	fluid	JJ
cord-277535-u283k70i	65	6	retention	retention	NN
cord-277535-u283k70i	65	7	and	and	CC
cord-277535-u283k70i	65	8	will	will	MD
cord-277535-u283k70i	65	9	increase	increase	VB
cord-277535-u283k70i	65	10	the	the	DT
cord-277535-u283k70i	65	11	volume	volume	NN
cord-277535-u283k70i	65	12	within	within	IN
cord-277535-u283k70i	65	13	which	which	WDT
cord-277535-u283k70i	65	14	drugs	drug	NNS
cord-277535-u283k70i	65	15	are	be	VBP
cord-277535-u283k70i	65	16	present	present	JJ
cord-277535-u283k70i	65	17	,	,	,
cord-277535-u283k70i	65	18	particularly	particularly	RB
cord-277535-u283k70i	65	19	those	those	DT
cord-277535-u283k70i	65	20	which	which	WDT
cord-277535-u283k70i	65	21	usually	usually	RB
cord-277535-u283k70i	65	22	remain	remain	VBP
cord-277535-u283k70i	65	23	in	in	IN
cord-277535-u283k70i	65	24	the	the	DT
cord-277535-u283k70i	65	25	plasma	plasma	NN
cord-277535-u283k70i	65	26	,	,	,
cord-277535-u283k70i	65	27	thus	thus	RB
cord-277535-u283k70i	65	28	increasing	increase	VBG
cord-277535-u283k70i	65	29	their	-PRON-	PRP$
cord-277535-u283k70i	65	30	volume	volume	NN
cord-277535-u283k70i	65	31	of	of	IN
cord-277535-u283k70i	65	32	distribution	distribution	NN
cord-277535-u283k70i	65	33	and	and	CC
cord-277535-u283k70i	65	34	reducing	reduce	VBG
cord-277535-u283k70i	65	35	their	-PRON-	PRP$
cord-277535-u283k70i	65	36	plasma	plasma	NN
cord-277535-u283k70i	65	37	concentration	concentration	NN
cord-277535-u283k70i	65	38	.	.	.
cord-277535-u283k70i	66	1	2	2	LS
cord-277535-u283k70i	67	1	In	in	IN
cord-277535-u283k70i	67	2	liver	liver	NN
cord-277535-u283k70i	67	3	disease	disease	NN
cord-277535-u283k70i	67	4	,	,	,
cord-277535-u283k70i	67	5	protein	protein	NN
cord-277535-u283k70i	67	6	synthesis	synthesis	NN
cord-277535-u283k70i	67	7	may	may	MD
cord-277535-u283k70i	67	8	be	be	VB
cord-277535-u283k70i	67	9	reduced	reduce	VBN
cord-277535-u283k70i	67	10	.	.	.
cord-277535-u283k70i	68	1	These	these	DT
cord-277535-u283k70i	68	2	proteins	protein	NNS
cord-277535-u283k70i	68	3	are	be	VBP
cord-277535-u283k70i	68	4	important	important	JJ
cord-277535-u283k70i	68	5	as	as	IN
cord-277535-u283k70i	68	6	binding	bind	VBG
cord-277535-u283k70i	68	7	sites	site	NNS
cord-277535-u283k70i	68	8	for	for	IN
cord-277535-u283k70i	68	9	drugs	drug	NNS
cord-277535-u283k70i	68	10	and	and	CC
cord-277535-u283k70i	68	11	as	as	IN
cord-277535-u283k70i	68	12	such	such	JJ
cord-277535-u283k70i	68	13	alter	alter	VB
cord-277535-u283k70i	68	14	the	the	DT
cord-277535-u283k70i	68	15	amount	amount	NN
cord-277535-u283k70i	68	16	of	of	IN
cord-277535-u283k70i	68	17	free	free	JJ
cord-277535-u283k70i	68	18	drug	drug	NN
cord-277535-u283k70i	68	19	available	available	JJ
cord-277535-u283k70i	68	20	,	,	,
cord-277535-u283k70i	68	21	volume	volume	NN
cord-277535-u283k70i	68	22	of	of	IN
cord-277535-u283k70i	68	23	distribution	distribution	NN
cord-277535-u283k70i	68	24	,	,	,
cord-277535-u283k70i	68	25	half	half	JJ
cord-277535-u283k70i	68	26	life	life	NN
cord-277535-u283k70i	68	27	and	and	CC
cord-277535-u283k70i	68	28	duration	duration	NN
cord-277535-u283k70i	68	29	of	of	IN
cord-277535-u283k70i	68	30	action	action	NN
cord-277535-u283k70i	68	31	.	.	.
cord-277535-u283k70i	69	1	An	an	DT
cord-277535-u283k70i	69	2	important	important	JJ
cord-277535-u283k70i	69	3	example	example	NN
cord-277535-u283k70i	69	4	is	be	VBZ
cord-277535-u283k70i	69	5	albumin	albumin	NN
cord-277535-u283k70i	69	6	.	.	.
cord-277535-u283k70i	70	1	Hypo	Hypo	NNP
cord-277535-u283k70i	70	2	-	-	HYPH
cord-277535-u283k70i	70	3	albuminaemia	albuminaemia	NN
cord-277535-u283k70i	70	4	will	will	MD
cord-277535-u283k70i	70	5	increase	increase	VB
cord-277535-u283k70i	70	6	the	the	DT
cord-277535-u283k70i	70	7	proportion	proportion	NN
cord-277535-u283k70i	70	8	of	of	IN
cord-277535-u283k70i	70	9	free	free	JJ
cord-277535-u283k70i	70	10	drug	drug	NN
cord-277535-u283k70i	70	11	which	which	WDT
cord-277535-u283k70i	70	12	is	be	VBZ
cord-277535-u283k70i	70	13	active	active	JJ
cord-277535-u283k70i	70	14	,	,	,
cord-277535-u283k70i	70	15	therefore	therefore	RB
cord-277535-u283k70i	70	16	doses	dose	NNS
cord-277535-u283k70i	70	17	of	of	IN
cord-277535-u283k70i	70	18	highly	highly	RB
cord-277535-u283k70i	70	19	protein	protein	NN
cord-277535-u283k70i	70	20	bound	bind	VBN
cord-277535-u283k70i	70	21	drugs	drug	NNS
cord-277535-u283k70i	70	22	may	may	MD
cord-277535-u283k70i	70	23	need	need	VB
cord-277535-u283k70i	70	24	to	to	TO
cord-277535-u283k70i	70	25	be	be	VB
cord-277535-u283k70i	70	26	reduced	reduce	VBN
cord-277535-u283k70i	70	27	,	,	,
cord-277535-u283k70i	70	28	for	for	IN
cord-277535-u283k70i	70	29	example	example	NN
cord-277535-u283k70i	70	30	phenytoin	phenytoin	NN
cord-277535-u283k70i	70	31	and	and	CC
cord-277535-u283k70i	70	32	benzodiazepines	benzodiazepine	NNS
cord-277535-u283k70i	70	33	,	,	,
cord-277535-u283k70i	70	34	aspirin	aspirin	NN
cord-277535-u283k70i	70	35	and	and	CC
cord-277535-u283k70i	70	36	warfarin	warfarin	NN
cord-277535-u283k70i	70	37	.	.	.
cord-277535-u283k70i	71	1	8	8	CD
cord-277535-u283k70i	72	1	Another	another	DT
cord-277535-u283k70i	72	2	protein	protein	NN
cord-277535-u283k70i	72	3	produced	produce	VBN
cord-277535-u283k70i	72	4	by	by	IN
cord-277535-u283k70i	72	5	the	the	DT
cord-277535-u283k70i	72	6	liver	liver	NN
cord-277535-u283k70i	72	7	,	,	,
cord-277535-u283k70i	72	8	a	a	DT
cord-277535-u283k70i	72	9	1	1	CD
cord-277535-u283k70i	72	10	acid	acid	NN
cord-277535-u283k70i	72	11	glycoprotein	glycoprotein	NN
cord-277535-u283k70i	72	12	binds	bind	VBZ
cord-277535-u283k70i	72	13	basic	basic	JJ
cord-277535-u283k70i	72	14	drugs	drug	NNS
cord-277535-u283k70i	72	15	such	such	JJ
cord-277535-u283k70i	72	16	as	as	IN
cord-277535-u283k70i	72	17	carbamazepine	carbamazepine	NN
cord-277535-u283k70i	72	18	,	,	,
cord-277535-u283k70i	72	19	propanolol	propanolol	NN
cord-277535-u283k70i	72	20	,	,	,
cord-277535-u283k70i	72	21	alprenolol	alprenolol	NNP
cord-277535-u283k70i	72	22	and	and	CC
cord-277535-u283k70i	72	23	imipramine	imipramine	NN
cord-277535-u283k70i	72	24	as	as	RB
cord-277535-u283k70i	72	25	well	well	RB
cord-277535-u283k70i	72	26	as	as	IN
cord-277535-u283k70i	72	27	steroids	steroid	NNS
cord-277535-u283k70i	72	28	.	.	.
cord-277535-u283k70i	73	1	Bilirubin	bilirubin	NN
cord-277535-u283k70i	73	2	can	can	MD
cord-277535-u283k70i	73	3	also	also	RB
cord-277535-u283k70i	73	4	compete	compete	VB
cord-277535-u283k70i	73	5	for	for	IN
cord-277535-u283k70i	73	6	protein	protein	NN
cord-277535-u283k70i	73	7	binding	bind	VBG
cord-277535-u283k70i	73	8	sites	site	NNS
cord-277535-u283k70i	73	9	,	,	,
cord-277535-u283k70i	73	10	so	so	RB
cord-277535-u283k70i	73	11	raised	raise	VBN
cord-277535-u283k70i	73	12	levels	level	NNS
cord-277535-u283k70i	73	13	can	can	MD
cord-277535-u283k70i	73	14	increase	increase	VB
cord-277535-u283k70i	73	15	amount	amount	NN
cord-277535-u283k70i	73	16	of	of	IN
cord-277535-u283k70i	73	17	free	free	JJ
cord-277535-u283k70i	73	18	drugs	drug	NNS
cord-277535-u283k70i	73	19	,	,	,
cord-277535-u283k70i	73	20	the	the	DT
cord-277535-u283k70i	73	21	effect	effect	NN
cord-277535-u283k70i	73	22	however	however	RB
cord-277535-u283k70i	73	23	is	be	VBZ
cord-277535-u283k70i	73	24	less	less	JJR
cord-277535-u283k70i	73	25	in	in	IN
cord-277535-u283k70i	73	26	vivo	vivo	NN
cord-277535-u283k70i	73	27	than	than	IN
cord-277535-u283k70i	73	28	in	in	IN
cord-277535-u283k70i	73	29	vitro	vitro	FW
cord-277535-u283k70i	73	30	.	.	.
cord-277535-u283k70i	74	1	1	1	LS
cord-277535-u283k70i	74	2	Problems	problem	NNS
cord-277535-u283k70i	74	3	with	with	IN
cord-277535-u283k70i	74	4	absorption	absorption	NN
cord-277535-u283k70i	74	5	of	of	IN
cord-277535-u283k70i	74	6	enterally	enterally	RB
cord-277535-u283k70i	74	7	delivered	deliver	VBN
cord-277535-u283k70i	74	8	drugs	drug	NNS
cord-277535-u283k70i	74	9	have	have	VBP
cord-277535-u283k70i	74	10	been	be	VBN
cord-277535-u283k70i	74	11	described	describe	VBN
cord-277535-u283k70i	74	12	.	.	.
cord-277535-u283k70i	75	1	Once	once	RB
cord-277535-u283k70i	75	2	absorbed	absorb	VBN
cord-277535-u283k70i	75	3	these	these	DT
cord-277535-u283k70i	75	4	drugs	drug	NNS
cord-277535-u283k70i	75	5	undergo	undergo	VBP
cord-277535-u283k70i	75	6	the	the	DT
cord-277535-u283k70i	75	7	"	"	``
cord-277535-u283k70i	75	8	first	first	JJ
cord-277535-u283k70i	75	9	pass	pass	NN
cord-277535-u283k70i	75	10	effect	effect	NN
cord-277535-u283k70i	75	11	"	"	''
cord-277535-u283k70i	75	12	by	by	IN
cord-277535-u283k70i	75	13	the	the	DT
cord-277535-u283k70i	75	14	liver	liver	NN
cord-277535-u283k70i	75	15	before	before	IN
cord-277535-u283k70i	75	16	reaching	reach	VBG
cord-277535-u283k70i	75	17	the	the	DT
cord-277535-u283k70i	75	18	systemic	systemic	JJ
cord-277535-u283k70i	75	19	circulation	circulation	NN
cord-277535-u283k70i	75	20	.	.	.
cord-277535-u283k70i	76	1	In	in	IN
cord-277535-u283k70i	76	2	liver	liver	NN
cord-277535-u283k70i	76	3	failure	failure	NN
cord-277535-u283k70i	77	1	the	the	DT
cord-277535-u283k70i	77	2	degree	degree	NN
cord-277535-u283k70i	77	3	of	of	IN
cord-277535-u283k70i	77	4	metabolism	metabolism	NN
cord-277535-u283k70i	77	5	will	will	MD
cord-277535-u283k70i	77	6	be	be	VB
cord-277535-u283k70i	77	7	reduced	reduce	VBN
cord-277535-u283k70i	77	8	,	,	,
cord-277535-u283k70i	77	9	therefore	therefore	RB
cord-277535-u283k70i	77	10	the	the	DT
cord-277535-u283k70i	77	11	extraction	extraction	NN
cord-277535-u283k70i	77	12	ratio	ratio	NN
cord-277535-u283k70i	77	13	will	will	MD
cord-277535-u283k70i	77	14	also	also	RB
cord-277535-u283k70i	77	15	be	be	VB
cord-277535-u283k70i	77	16	reduced	reduce	VBN
cord-277535-u283k70i	77	17	and	and	CC
cord-277535-u283k70i	77	18	more	more	JJR
cord-277535-u283k70i	77	19	drug	drug	NN
cord-277535-u283k70i	77	20	will	will	MD
cord-277535-u283k70i	77	21	reach	reach	VB
cord-277535-u283k70i	77	22	the	the	DT
cord-277535-u283k70i	77	23	systemic	systemic	JJ
cord-277535-u283k70i	77	24	circulation	circulation	NN
cord-277535-u283k70i	77	25	,	,	,
cord-277535-u283k70i	77	26	thus	thus	RB
cord-277535-u283k70i	77	27	increasing	increase	VBG
cord-277535-u283k70i	77	28	bioavailability	bioavailability	NN
cord-277535-u283k70i	77	29	.	.	.
cord-277535-u283k70i	78	1	Prevalence	prevalence	NN
cord-277535-u283k70i	78	2	of	of	IN
cord-277535-u283k70i	78	3	ultrarapid	ultrarapid	NN
cord-277535-u283k70i	78	4	metabolisers	metaboliser	VBZ
cord-277535-u283k70i	78	5	Metabolism	metabolism	NN
cord-277535-u283k70i	78	6	of	of	IN
cord-277535-u283k70i	78	7	drugs	drug	NNS
cord-277535-u283k70i	78	8	in	in	IN
cord-277535-u283k70i	78	9	liver	liver	NN
cord-277535-u283k70i	78	10	disease	disease	NN
cord-277535-u283k70i	78	11	depends	depend	VBZ
cord-277535-u283k70i	78	12	on	on	IN
cord-277535-u283k70i	78	13	liver	liver	NN
cord-277535-u283k70i	78	14	blood	blood	NN
cord-277535-u283k70i	78	15	flow	flow	NN
cord-277535-u283k70i	78	16	.	.	.
cord-277535-u283k70i	79	1	This	this	DT
cord-277535-u283k70i	79	2	can	can	MD
cord-277535-u283k70i	79	3	be	be	VB
cord-277535-u283k70i	79	4	reduced	reduce	VBN
cord-277535-u283k70i	79	5	in	in	IN
cord-277535-u283k70i	79	6	a	a	DT
cord-277535-u283k70i	79	7	cirrhotic	cirrhotic	JJ
cord-277535-u283k70i	79	8	liver	liver	NN
cord-277535-u283k70i	79	9	as	as	IN
cord-277535-u283k70i	79	10	portovenous	portovenous	JJ
cord-277535-u283k70i	79	11	shunting	shunt	VBG
cord-277535-u283k70i	79	12	in	in	IN
cord-277535-u283k70i	79	13	the	the	DT
cord-277535-u283k70i	79	14	form	form	NN
cord-277535-u283k70i	79	15	of	of	IN
cord-277535-u283k70i	79	16	varices	varix	NNS
cord-277535-u283k70i	79	17	which	which	WDT
cord-277535-u283k70i	79	18	are	be	VBP
cord-277535-u283k70i	79	19	created	create	VBN
cord-277535-u283k70i	79	20	and	and	CC
cord-277535-u283k70i	79	21	blood	blood	NN
cord-277535-u283k70i	79	22	is	be	VBZ
cord-277535-u283k70i	79	23	diverted	divert	VBN
cord-277535-u283k70i	79	24	directly	directly	RB
cord-277535-u283k70i	79	25	into	into	IN
cord-277535-u283k70i	79	26	the	the	DT
cord-277535-u283k70i	79	27	systemic	systemic	JJ
cord-277535-u283k70i	79	28	circulation	circulation	NN
cord-277535-u283k70i	79	29	by	by	IN
cord-277535-u283k70i	79	30	-	-	HYPH
cord-277535-u283k70i	79	31	passing	pass	VBG
cord-277535-u283k70i	79	32	the	the	DT
cord-277535-u283k70i	79	33	liver	liver	NN
cord-277535-u283k70i	79	34	.	.	.
cord-277535-u283k70i	80	1	Thus	thus	RB
cord-277535-u283k70i	80	2	first	first	JJ
cord-277535-u283k70i	80	3	pass	pass	NN
cord-277535-u283k70i	80	4	metabolism	metabolism	NN
cord-277535-u283k70i	80	5	is	be	VBZ
cord-277535-u283k70i	80	6	reduced	reduce	VBN
cord-277535-u283k70i	80	7	.	.	.
cord-277535-u283k70i	81	1	Drug	drug	NN
cord-277535-u283k70i	81	2	metabolism	metabolism	NN
cord-277535-u283k70i	81	3	by	by	IN
cord-277535-u283k70i	81	4	the	the	DT
cord-277535-u283k70i	81	5	liver	liver	NN
cord-277535-u283k70i	81	6	may	may	MD
cord-277535-u283k70i	81	7	also	also	RB
cord-277535-u283k70i	81	8	be	be	VB
cord-277535-u283k70i	81	9	reduced	reduce	VBN
cord-277535-u283k70i	81	10	by	by	IN
cord-277535-u283k70i	81	11	the	the	DT
cord-277535-u283k70i	81	12	use	use	NN
cord-277535-u283k70i	81	13	of	of	IN
cord-277535-u283k70i	81	14	vasopressors	vasopressor	NNS
cord-277535-u283k70i	81	15	on	on	IN
cord-277535-u283k70i	81	16	intensive	intensive	JJ
cord-277535-u283k70i	81	17	care	care	NN
cord-277535-u283k70i	81	18	which	which	WDT
cord-277535-u283k70i	81	19	reduce	reduce	VBP
cord-277535-u283k70i	81	20	liver	liver	NN
cord-277535-u283k70i	81	21	blood	blood	NN
cord-277535-u283k70i	81	22	flow	flow	NN
cord-277535-u283k70i	81	23	due	due	IN
cord-277535-u283k70i	81	24	to	to	IN
cord-277535-u283k70i	81	25	varying	vary	VBG
cord-277535-u283k70i	81	26	degrees	degree	NNS
cord-277535-u283k70i	81	27	of	of	IN
cord-277535-u283k70i	81	28	splanchnic	splanchnic	JJ
cord-277535-u283k70i	81	29	vasoconstriction	vasoconstriction	NN
cord-277535-u283k70i	81	30	.	.	.
cord-277535-u283k70i	82	1	The	the	DT
cord-277535-u283k70i	82	2	phase	phase	NN
cord-277535-u283k70i	82	3	1	1	CD
cord-277535-u283k70i	82	4	and	and	CC
cord-277535-u283k70i	82	5	2	2	CD
cord-277535-u283k70i	82	6	reactions	reaction	NNS
cord-277535-u283k70i	82	7	performed	perform	VBN
cord-277535-u283k70i	82	8	by	by	IN
cord-277535-u283k70i	82	9	the	the	DT
cord-277535-u283k70i	82	10	liver	liver	NN
cord-277535-u283k70i	82	11	are	be	VBP
cord-277535-u283k70i	82	12	affected	affect	VBN
cord-277535-u283k70i	82	13	and	and	CC
cord-277535-u283k70i	82	14	metabolism	metabolism	NN
cord-277535-u283k70i	82	15	and	and	CC
cord-277535-u283k70i	82	16	thus	thus	RB
cord-277535-u283k70i	82	17	extraction	extraction	NN
cord-277535-u283k70i	82	18	ratios	ratio	NNS
cord-277535-u283k70i	82	19	are	be	VBP
cord-277535-u283k70i	82	20	reduced	reduce	VBN
cord-277535-u283k70i	82	21	.	.	.
cord-277535-u283k70i	83	1	Drugs	drug	NNS
cord-277535-u283k70i	83	2	can	can	MD
cord-277535-u283k70i	83	3	be	be	VB
cord-277535-u283k70i	83	4	divided	divide	VBN
cord-277535-u283k70i	83	5	into	into	IN
cord-277535-u283k70i	83	6	those	those	DT
cord-277535-u283k70i	83	7	with	with	IN
cord-277535-u283k70i	83	8	high	high	JJ
cord-277535-u283k70i	83	9	extraction	extraction	NN
cord-277535-u283k70i	83	10	ratios	ratio	NNS
cord-277535-u283k70i	83	11	>	>	XX
cord-277535-u283k70i	84	1	0.7	0.7	CD
cord-277535-u283k70i	84	2	,	,	,
cord-277535-u283k70i	84	3	for	for	IN
cord-277535-u283k70i	84	4	example	example	NN
cord-277535-u283k70i	84	5	fentanyl	fentanyl	NN
cord-277535-u283k70i	84	6	and	and	CC
cord-277535-u283k70i	84	7	morphine	morphine	NN
cord-277535-u283k70i	84	8	and	and	CC
cord-277535-u283k70i	84	9	low	low	JJ
cord-277535-u283k70i	84	10	extraction	extraction	NN
cord-277535-u283k70i	84	11	ratios	ratio	NNS
cord-277535-u283k70i	84	12	<	<	XX
cord-277535-u283k70i	84	13	0.3	0.3	CD
cord-277535-u283k70i	84	14	such	such	JJ
cord-277535-u283k70i	84	15	as	as	IN
cord-277535-u283k70i	84	16	lorazepam	lorazepam	NN
cord-277535-u283k70i	84	17	,	,	,
cord-277535-u283k70i	84	18	diazepam	diazepam	NN
cord-277535-u283k70i	84	19	and	and	CC
cord-277535-u283k70i	84	20	methadone	methadone	NN
cord-277535-u283k70i	84	21	.	.	.
cord-277535-u283k70i	85	1	Most	Most	JJS
cord-277535-u283k70i	85	2	drugs	drug	NNS
cord-277535-u283k70i	85	3	have	have	VBP
cord-277535-u283k70i	85	4	low	low	JJ
cord-277535-u283k70i	85	5	extraction	extraction	NN
cord-277535-u283k70i	85	6	ratios	ratio	NNS
cord-277535-u283k70i	85	7	<	<	XX
cord-277535-u283k70i	85	8	0.3	0.3	CD
cord-277535-u283k70i	85	9	that	that	WDT
cord-277535-u283k70i	85	10	is	is	RB
cord-277535-u283k70i	85	11	they	-PRON-	PRP
cord-277535-u283k70i	85	12	have	have	VBP
cord-277535-u283k70i	85	13	poor	poor	JJ
cord-277535-u283k70i	85	14	permeability	permeability	NN
cord-277535-u283k70i	85	15	and	and	CC
cord-277535-u283k70i	85	16	are	be	VBP
cord-277535-u283k70i	85	17	metabolized	metabolize	VBN
cord-277535-u283k70i	85	18	by	by	IN
cord-277535-u283k70i	85	19	the	the	DT
cord-277535-u283k70i	85	20	liver	liver	NN
cord-277535-u283k70i	85	21	but	but	CC
cord-277535-u283k70i	85	22	poorly	poorly	RB
cord-277535-u283k70i	85	23	extracted	extract	VBN
cord-277535-u283k70i	85	24	,	,	,
cord-277535-u283k70i	85	25	therefore	therefore	RB
cord-277535-u283k70i	85	26	clearance	clearance	NN
cord-277535-u283k70i	85	27	is	be	VBZ
cord-277535-u283k70i	85	28	limited	limit	VBN
cord-277535-u283k70i	85	29	by	by	IN
cord-277535-u283k70i	85	30	reduced	reduced	JJ
cord-277535-u283k70i	85	31	metabolism	metabolism	NN
cord-277535-u283k70i	85	32	not	not	RB
cord-277535-u283k70i	85	33	by	by	IN
cord-277535-u283k70i	85	34	blood	blood	NN
cord-277535-u283k70i	85	35	flow	flow	NN
cord-277535-u283k70i	85	36	.	.	.
cord-277535-u283k70i	86	1	Those	those	DT
cord-277535-u283k70i	86	2	with	with	IN
cord-277535-u283k70i	86	3	high	high	JJ
cord-277535-u283k70i	86	4	extraction	extraction	NN
cord-277535-u283k70i	86	5	ratios	ratio	NNS
cord-277535-u283k70i	86	6	>	>	XX
cord-277535-u283k70i	87	1	0.7	0.7	CD
cord-277535-u283k70i	87	2	are	be	VBP
cord-277535-u283k70i	87	3	highly	highly	RB
cord-277535-u283k70i	87	4	permeable	permeable	JJ
cord-277535-u283k70i	87	5	and	and	CC
cord-277535-u283k70i	87	6	clearance	clearance	NN
cord-277535-u283k70i	87	7	is	be	VBZ
cord-277535-u283k70i	87	8	dependent	dependent	JJ
cord-277535-u283k70i	87	9	on	on	IN
cord-277535-u283k70i	87	10	blood	blood	NN
cord-277535-u283k70i	87	11	flow	flow	NN
cord-277535-u283k70i	87	12	.	.	.
cord-277535-u283k70i	88	1	9	9	CD
cord-277535-u283k70i	88	2	Hepatic	hepatic	JJ
cord-277535-u283k70i	88	3	dysfunction	dysfunction	NN
cord-277535-u283k70i	88	4	is	be	VBZ
cord-277535-u283k70i	88	5	not	not	RB
cord-277535-u283k70i	88	6	uncommon	uncommon	JJ
cord-277535-u283k70i	88	7	within	within	IN
cord-277535-u283k70i	88	8	the	the	DT
cord-277535-u283k70i	88	9	intensive	intensive	JJ
cord-277535-u283k70i	88	10	care	care	NN
cord-277535-u283k70i	88	11	setting	set	VBG
cord-277535-u283k70i	88	12	affecting	affect	VBG
cord-277535-u283k70i	88	13	11e54	11e54	CD
cord-277535-u283k70i	88	14	%	%	NN
cord-277535-u283k70i	88	15	of	of	IN
cord-277535-u283k70i	88	16	critically	critically	RB
cord-277535-u283k70i	88	17	ill	ill	JJ
cord-277535-u283k70i	88	18	patients	patient	NNS
cord-277535-u283k70i	88	19	depending	depend	VBG
cord-277535-u283k70i	88	20	on	on	IN
cord-277535-u283k70i	88	21	definitions	definition	NNS
cord-277535-u283k70i	88	22	used	use	VBN
cord-277535-u283k70i	88	23	.	.	.
cord-277535-u283k70i	89	1	2	2	LS
cord-277535-u283k70i	90	1	There	there	EX
cord-277535-u283k70i	90	2	is	be	VBZ
cord-277535-u283k70i	90	3	currently	currently	RB
cord-277535-u283k70i	90	4	no	no	DT
cord-277535-u283k70i	90	5	tool	tool	NN
cord-277535-u283k70i	90	6	akin	akin	JJ
cord-277535-u283k70i	90	7	to	to	IN
cord-277535-u283k70i	90	8	renal	renal	JJ
cord-277535-u283k70i	90	9	clearance	clearance	NN
cord-277535-u283k70i	90	10	to	to	TO
cord-277535-u283k70i	90	11	indicate	indicate	VB
cord-277535-u283k70i	90	12	degree	degree	NN
cord-277535-u283k70i	90	13	of	of	IN
cord-277535-u283k70i	90	14	liver	liver	NN
cord-277535-u283k70i	90	15	dysfunction	dysfunction	NN
cord-277535-u283k70i	90	16	.	.	.
cord-277535-u283k70i	91	1	9	9	CD
cord-277535-u283k70i	92	1	Therefore	therefore	RB
cord-277535-u283k70i	92	2	clinicians	clinician	NNS
cord-277535-u283k70i	92	3	use	use	VBP
cord-277535-u283k70i	92	4	liver	liver	NN
cord-277535-u283k70i	92	5	function	function	NN
cord-277535-u283k70i	92	6	blood	blood	NN
cord-277535-u283k70i	92	7	tests	test	NNS
cord-277535-u283k70i	92	8	,	,	,
cord-277535-u283k70i	92	9	international	international	JJ
cord-277535-u283k70i	92	10	normalized	normalized	JJ
cord-277535-u283k70i	92	11	ratio	ratio	NN
cord-277535-u283k70i	92	12	(	(	-LRB-
cord-277535-u283k70i	92	13	INR	INR	NNP
cord-277535-u283k70i	92	14	)	)	-RRB-
cord-277535-u283k70i	92	15	,	,	,
cord-277535-u283k70i	92	16	serum	serum	NN
cord-277535-u283k70i	92	17	albumin	albumin	NN
cord-277535-u283k70i	92	18	and	and	CC
cord-277535-u283k70i	92	19	clinical	clinical	JJ
cord-277535-u283k70i	92	20	scores	score	NNS
cord-277535-u283k70i	92	21	such	such	JJ
cord-277535-u283k70i	92	22	as	as	IN
cord-277535-u283k70i	92	23	the	the	DT
cord-277535-u283k70i	92	24	Child	Child	NNP
cord-277535-u283k70i	92	25	Pugh	Pugh	NNP
cord-277535-u283k70i	92	26	score	score	NN
cord-277535-u283k70i	92	27	act	act	NN
cord-277535-u283k70i	92	28	as	as	IN
cord-277535-u283k70i	92	29	a	a	DT
cord-277535-u283k70i	92	30	surrogate	surrogate	NN
cord-277535-u283k70i	92	31	for	for	IN
cord-277535-u283k70i	92	32	function	function	NN
cord-277535-u283k70i	92	33	.	.	.
cord-277535-u283k70i	93	1	More	More	JJR
cord-277535-u283k70i	93	2	recently	recently	RB
cord-277535-u283k70i	93	3	the	the	DT
cord-277535-u283k70i	93	4	Model	Model	NNP
cord-277535-u283k70i	93	5	for	for	IN
cord-277535-u283k70i	93	6	End	End	NNP
cord-277535-u283k70i	93	7	Stage	Stage	NNP
cord-277535-u283k70i	93	8	Liver	liver	NN
cord-277535-u283k70i	93	9	Disease	disease	NN
cord-277535-u283k70i	93	10	(	(	-LRB-
cord-277535-u283k70i	93	11	MELD	MELD	NNP
cord-277535-u283k70i	93	12	Score	Score	NNP
cord-277535-u283k70i	93	13	)	)	-RRB-
cord-277535-u283k70i	93	14	and	and	CC
cord-277535-u283k70i	93	15	the	the	DT
cord-277535-u283k70i	93	16	MELD	MELD	NNP
cord-277535-u283k70i	93	17	-	-	HYPH
cord-277535-u283k70i	93	18	Na	Na	NNP
cord-277535-u283k70i	93	19	have	have	VBP
cord-277535-u283k70i	93	20	been	be	VBN
cord-277535-u283k70i	93	21	used	use	VBN
cord-277535-u283k70i	93	22	to	to	TO
cord-277535-u283k70i	93	23	more	more	RBR
cord-277535-u283k70i	93	24	accurately	accurately	RB
cord-277535-u283k70i	93	25	predict	predict	VB
cord-277535-u283k70i	93	26	the	the	DT
cord-277535-u283k70i	93	27	severity	severity	NN
cord-277535-u283k70i	93	28	of	of	IN
cord-277535-u283k70i	93	29	liver	liver	NN
cord-277535-u283k70i	93	30	dysfunction	dysfunction	NN
cord-277535-u283k70i	93	31	.	.	.
cord-277535-u283k70i	94	1	10	10	CD
cord-277535-u283k70i	94	2	,	,	,
cord-277535-u283k70i	94	3	11	11	CD
cord-277535-u283k70i	95	1	Although	although	IN
cord-277535-u283k70i	95	2	their	-PRON-	PRP$
cord-277535-u283k70i	95	3	correlation	correlation	NN
cord-277535-u283k70i	95	4	with	with	IN
cord-277535-u283k70i	95	5	pharmacokinetic	pharmacokinetic	JJ
cord-277535-u283k70i	95	6	function	function	NN
cord-277535-u283k70i	95	7	not	not	RB
cord-277535-u283k70i	95	8	well	well	RB
cord-277535-u283k70i	95	9	understood	understand	VBN
cord-277535-u283k70i	95	10	.	.	.
cord-277535-u283k70i	96	1	Due	due	IN
cord-277535-u283k70i	96	2	to	to	IN
cord-277535-u283k70i	96	3	the	the	DT
cord-277535-u283k70i	96	4	alterations	alteration	NNS
cord-277535-u283k70i	96	5	discussed	discuss	VBN
cord-277535-u283k70i	96	6	in	in	IN
cord-277535-u283k70i	96	7	pharmacokinetics	pharmacokinetic	NNS
cord-277535-u283k70i	96	8	in	in	IN
cord-277535-u283k70i	96	9	liver	liver	NN
cord-277535-u283k70i	96	10	dysfunction	dysfunction	NN
cord-277535-u283k70i	96	11	drug	drug	NN
cord-277535-u283k70i	96	12	choices	choice	NNS
cord-277535-u283k70i	96	13	,	,	,
cord-277535-u283k70i	96	14	dosages	dosage	NNS
cord-277535-u283k70i	96	15	and	and	CC
cord-277535-u283k70i	96	16	frequency	frequency	NN
cord-277535-u283k70i	96	17	may	may	MD
cord-277535-u283k70i	96	18	need	need	VB
cord-277535-u283k70i	96	19	to	to	TO
cord-277535-u283k70i	96	20	be	be	VB
cord-277535-u283k70i	96	21	rationalized	rationalize	VBN
cord-277535-u283k70i	96	22	and	and	CC
cord-277535-u283k70i	96	23	altered	alter	VBN
cord-277535-u283k70i	96	24	accordingly	accordingly	RB
cord-277535-u283k70i	96	25	.	.	.
cord-277535-u283k70i	97	1	For	for	IN
cord-277535-u283k70i	97	2	example	example	NN
cord-277535-u283k70i	97	3	the	the	DT
cord-277535-u283k70i	97	4	induction	induction	NN
cord-277535-u283k70i	97	5	dose	dose	NN
cord-277535-u283k70i	97	6	and	and	CC
cord-277535-u283k70i	97	7	maintenance	maintenance	NN
cord-277535-u283k70i	97	8	dose	dose	NN
cord-277535-u283k70i	97	9	,	,	,
cord-277535-u283k70i	97	10	for	for	IN
cord-277535-u283k70i	97	11	either	either	CC
cord-277535-u283k70i	97	12	anaesthesia	anaesthesia	NN
cord-277535-u283k70i	97	13	or	or	CC
cord-277535-u283k70i	97	14	sedation	sedation	NN
cord-277535-u283k70i	97	15	,	,	,
cord-277535-u283k70i	97	16	needs	need	VBZ
cord-277535-u283k70i	97	17	to	to	TO
cord-277535-u283k70i	97	18	be	be	VB
cord-277535-u283k70i	97	19	reduced	reduce	VBN
cord-277535-u283k70i	97	20	.	.	.
cord-277535-u283k70i	98	1	Historically	historically	RB
cord-277535-u283k70i	98	2	inhalational	inhalational	JJ
cord-277535-u283k70i	98	3	agents	agent	NNS
cord-277535-u283k70i	98	4	,	,	,
cord-277535-u283k70i	98	5	particularly	particularly	RB
cord-277535-u283k70i	98	6	halothane	halothane	NNP
cord-277535-u283k70i	98	7	have	have	VBP
cord-277535-u283k70i	98	8	been	be	VBN
cord-277535-u283k70i	98	9	implicated	implicate	VBN
cord-277535-u283k70i	98	10	in	in	IN
cord-277535-u283k70i	98	11	causing	cause	VBG
cord-277535-u283k70i	98	12	hepatitis	hepatitis	NN
cord-277535-u283k70i	98	13	.	.	.
cord-277535-u283k70i	99	1	The	the	DT
cord-277535-u283k70i	99	2	risk	risk	NN
cord-277535-u283k70i	99	3	is	be	VBZ
cord-277535-u283k70i	99	4	related	relate	VBN
cord-277535-u283k70i	99	5	to	to	IN
cord-277535-u283k70i	99	6	the	the	DT
cord-277535-u283k70i	99	7	generation	generation	NN
cord-277535-u283k70i	99	8	of	of	IN
cord-277535-u283k70i	99	9	trifluroacteyl	trifluroacteyl	NN
cord-277535-u283k70i	99	10	chloride	chloride	NN
cord-277535-u283k70i	99	11	(	(	-LRB-
cord-277535-u283k70i	99	12	TFA	TFA	NNP
cord-277535-u283k70i	99	13	)	)	-RRB-
cord-277535-u283k70i	99	14	by	by	IN
cord-277535-u283k70i	99	15	metabolism	metabolism	NN
cord-277535-u283k70i	99	16	of	of	IN
cord-277535-u283k70i	99	17	agents	agent	NNS
cord-277535-u283k70i	99	18	,	,	,
cord-277535-u283k70i	99	19	which	which	WDT
cord-277535-u283k70i	99	20	is	be	VBZ
cord-277535-u283k70i	99	21	implicated	implicate	VBN
cord-277535-u283k70i	99	22	in	in	IN
cord-277535-u283k70i	99	23	toxicity	toxicity	NN
cord-277535-u283k70i	99	24	12	12	CD
cord-277535-u283k70i	99	25	Around	around	IN
cord-277535-u283k70i	99	26	20	20	CD
cord-277535-u283k70i	99	27	%	%	NN
cord-277535-u283k70i	99	28	of	of	IN
cord-277535-u283k70i	99	29	administered	administer	VBN
cord-277535-u283k70i	99	30	dose	dose	NN
cord-277535-u283k70i	99	31	of	of	IN
cord-277535-u283k70i	99	32	halothane	halothane	NNP
cord-277535-u283k70i	99	33	is	be	VBZ
cord-277535-u283k70i	99	34	metabolized	metabolize	VBN
cord-277535-u283k70i	99	35	by	by	IN
cord-277535-u283k70i	99	36	the	the	DT
cord-277535-u283k70i	99	37	liver	liver	NN
cord-277535-u283k70i	99	38	,	,	,
cord-277535-u283k70i	99	39	more	more	RBR
cord-277535-u283k70i	99	40	specifically	specifically	RB
cord-277535-u283k70i	99	41	by	by	IN
cord-277535-u283k70i	99	42	cytochrome	cytochrome	NN
cord-277535-u283k70i	99	43	P450	p450	NN
cord-277535-u283k70i	99	44	.	.	.
cord-277535-u283k70i	100	1	This	this	DT
cord-277535-u283k70i	100	2	is	be	VBZ
cord-277535-u283k70i	100	3	a	a	DT
cord-277535-u283k70i	100	4	relatively	relatively	RB
cord-277535-u283k70i	100	5	high	high	JJ
cord-277535-u283k70i	100	6	percentage	percentage	NN
cord-277535-u283k70i	100	7	when	when	WRB
cord-277535-u283k70i	100	8	compared	compare	VBN
cord-277535-u283k70i	100	9	to	to	IN
cord-277535-u283k70i	100	10	more	more	JJR
cord-277535-u283k70i	100	11	modern	modern	JJ
cord-277535-u283k70i	100	12	inhalational	inhalational	JJ
cord-277535-u283k70i	100	13	agents	agent	NNS
cord-277535-u283k70i	100	14	,	,	,
cord-277535-u283k70i	100	15	for	for	IN
cord-277535-u283k70i	100	16	example	example	NN
cord-277535-u283k70i	100	17	,	,	,
cord-277535-u283k70i	100	18	0.2	0.2	CD
cord-277535-u283k70i	100	19	%	%	NN
cord-277535-u283k70i	100	20	isoflurane	isoflurane	NN
cord-277535-u283k70i	100	21	,	,	,
cord-277535-u283k70i	100	22	0.02	0.02	CD
cord-277535-u283k70i	100	23	%	%	NN
cord-277535-u283k70i	100	24	desflurane	desflurane	NN
cord-277535-u283k70i	100	25	and	and	CC
cord-277535-u283k70i	100	26	3	3	CD
cord-277535-u283k70i	100	27	%	%	NN
cord-277535-u283k70i	100	28	sevoflurane	sevoflurane	NN
cord-277535-u283k70i	100	29	.	.	.
cord-277535-u283k70i	101	1	even	even	RB
cord-277535-u283k70i	101	2	though	though	IN
cord-277535-u283k70i	101	3	sevoflurane	sevoflurane	NNP
cord-277535-u283k70i	101	4	undergoes	undergo	VBZ
cord-277535-u283k70i	101	5	3	3	CD
cord-277535-u283k70i	101	6	%	%	NN
cord-277535-u283k70i	101	7	metabolism	metabolism	NN
cord-277535-u283k70i	101	8	it	-PRON-	PRP
cord-277535-u283k70i	101	9	does	do	VBZ
cord-277535-u283k70i	101	10	not	not	RB
cord-277535-u283k70i	101	11	generate	generate	VB
cord-277535-u283k70i	101	12	TFA	TFA	NNP
cord-277535-u283k70i	101	13	and	and	CC
cord-277535-u283k70i	101	14	hence	hence	RB
cord-277535-u283k70i	101	15	is	be	VBZ
cord-277535-u283k70i	101	16	not	not	RB
cord-277535-u283k70i	101	17	linked	link	VBN
cord-277535-u283k70i	101	18	to	to	IN
cord-277535-u283k70i	101	19	immune	immune	JJ
cord-277535-u283k70i	101	20	mediated	mediate	VBN
cord-277535-u283k70i	101	21	injury	injury	NN
cord-277535-u283k70i	101	22	13	13	CD
cord-277535-u283k70i	101	23	Sevoflurane	Sevoflurane	NNP
cord-277535-u283k70i	101	24	metabolism	metabolism	NN
cord-277535-u283k70i	101	25	produces	produce	VBZ
cord-277535-u283k70i	101	26	fluoride	fluoride	NN
cord-277535-u283k70i	101	27	which	which	WDT
cord-277535-u283k70i	101	28	is	be	VBZ
cord-277535-u283k70i	101	29	not	not	RB
cord-277535-u283k70i	101	30	linked	link	VBN
cord-277535-u283k70i	101	31	to	to	IN
cord-277535-u283k70i	101	32	hepatotoxicity	hepatotoxicity	NN
cord-277535-u283k70i	101	33	.	.	.
cord-277535-u283k70i	102	1	14	14	CD
cord-277535-u283k70i	102	2	Inhalational	Inhalational	NNP
cord-277535-u283k70i	102	3	agents	agent	NNS
cord-277535-u283k70i	102	4	themselves	-PRON-	PRP
cord-277535-u283k70i	102	5	cause	cause	VBP
cord-277535-u283k70i	102	6	a	a	DT
cord-277535-u283k70i	102	7	dose	dose	JJ
cord-277535-u283k70i	102	8	dependent	dependent	JJ
cord-277535-u283k70i	102	9	reduction	reduction	NN
cord-277535-u283k70i	102	10	in	in	IN
cord-277535-u283k70i	102	11	hepatic	hepatic	JJ
cord-277535-u283k70i	102	12	blood	blood	NN
cord-277535-u283k70i	102	13	flow	flow	NN
cord-277535-u283k70i	102	14	(	(	-LRB-
cord-277535-u283k70i	102	15	HBF	HBF	NNP
cord-277535-u283k70i	102	16	)	)	-RRB-
cord-277535-u283k70i	102	17	.	.	.
cord-277535-u283k70i	103	1	Isoflurane	Isoflurane	NNP
cord-277535-u283k70i	103	2	and	and	CC
cord-277535-u283k70i	103	3	sevoflurane	sevoflurane	NNP
cord-277535-u283k70i	103	4	result	result	VBP
cord-277535-u283k70i	103	5	in	in	IN
cord-277535-u283k70i	103	6	relatively	relatively	RB
cord-277535-u283k70i	103	7	lower	low	JJR
cord-277535-u283k70i	103	8	reduction	reduction	NN
cord-277535-u283k70i	103	9	in	in	IN
cord-277535-u283k70i	103	10	HBF	HBF	NNP
cord-277535-u283k70i	103	11	at	at	IN
cord-277535-u283k70i	103	12	1	1	CD
cord-277535-u283k70i	103	13	MAC	MAC	NNP
cord-277535-u283k70i	103	14	as	as	IN
cord-277535-u283k70i	103	15	compared	compare	VBN
cord-277535-u283k70i	103	16	to	to	IN
cord-277535-u283k70i	103	17	Desflurane	Desflurane	NNP
cord-277535-u283k70i	103	18	.	.	.
cord-277535-u283k70i	104	1	15	15	CD
cord-277535-u283k70i	105	1	As	as	RB
cord-277535-u283k70i	105	2	long	long	RB
cord-277535-u283k70i	105	3	as	as	IN
cord-277535-u283k70i	105	4	hypotension	hypotension	NN
cord-277535-u283k70i	105	5	is	be	VBZ
cord-277535-u283k70i	105	6	avoided	avoid	VBN
cord-277535-u283k70i	105	7	and	and	CC
cord-277535-u283k70i	105	8	above	above	IN
cord-277535-u283k70i	105	9	effects	effect	NNS
cord-277535-u283k70i	105	10	are	be	VBP
cord-277535-u283k70i	105	11	kept	keep	VBN
cord-277535-u283k70i	105	12	in	in	IN
cord-277535-u283k70i	105	13	mind	mind	NN
cord-277535-u283k70i	106	1	Desflurane	Desflurane	NNP
cord-277535-u283k70i	106	2	is	be	VBZ
cord-277535-u283k70i	106	3	probably	probably	RB
cord-277535-u283k70i	106	4	the	the	DT
cord-277535-u283k70i	106	5	safest	safe	JJS
cord-277535-u283k70i	106	6	choice	choice	NN
cord-277535-u283k70i	106	7	of	of	IN
cord-277535-u283k70i	106	8	inhalational	inhalational	JJ
cord-277535-u283k70i	106	9	agent	agent	NN
cord-277535-u283k70i	106	10	due	due	IN
cord-277535-u283k70i	106	11	to	to	IN
cord-277535-u283k70i	106	12	its	-PRON-	PRP$
cord-277535-u283k70i	106	13	'	'	``
cord-277535-u283k70i	106	14	low	low	JJ
cord-277535-u283k70i	106	15	rate	rate	NN
cord-277535-u283k70i	106	16	of	of	IN
cord-277535-u283k70i	106	17	metabolism	metabolism	NN
cord-277535-u283k70i	106	18	and	and	CC
cord-277535-u283k70i	106	19	rapid	rapid	JJ
cord-277535-u283k70i	106	20	and	and	CC
cord-277535-u283k70i	106	21	predictable	predictable	JJ
cord-277535-u283k70i	106	22	emergence	emergence	NN
cord-277535-u283k70i	106	23	from	from	IN
cord-277535-u283k70i	106	24	anaesthesia	anaesthesia	NN
cord-277535-u283k70i	106	25	.	.	.
cord-277535-u283k70i	107	1	13	13	CD
cord-277535-u283k70i	108	1	There	there	EX
cord-277535-u283k70i	108	2	are	be	VBP
cord-277535-u283k70i	108	3	two	two	CD
cord-277535-u283k70i	108	4	types	type	NNS
cord-277535-u283k70i	108	5	of	of	IN
cord-277535-u283k70i	108	6	halothane	halothane	NNP
cord-277535-u283k70i	108	7	hepatitis	hepatitis	NNP
cord-277535-u283k70i	108	8	.	.	.
cord-277535-u283k70i	109	1	Type	type	NN
cord-277535-u283k70i	109	2	1	1	CD
cord-277535-u283k70i	109	3	which	which	WDT
cord-277535-u283k70i	109	4	is	be	VBZ
cord-277535-u283k70i	109	5	mild	mild	JJ
cord-277535-u283k70i	109	6	,	,	,
cord-277535-u283k70i	109	7	transient	transient	JJ
cord-277535-u283k70i	109	8	and	and	CC
cord-277535-u283k70i	109	9	has	have	VBZ
cord-277535-u283k70i	109	10	a	a	DT
cord-277535-u283k70i	109	11	relatively	relatively	RB
cord-277535-u283k70i	109	12	high	high	JJ
cord-277535-u283k70i	109	13	incidence	incidence	NN
cord-277535-u283k70i	109	14	(	(	-LRB-
cord-277535-u283k70i	109	15	25e30	25e30	CD
cord-277535-u283k70i	109	16	%	%	NN
cord-277535-u283k70i	109	17	)	)	-RRB-
cord-277535-u283k70i	109	18	.	.	.
cord-277535-u283k70i	110	1	Type	type	NN
cord-277535-u283k70i	110	2	2	2	CD
cord-277535-u283k70i	110	3	caused	cause	VBN
cord-277535-u283k70i	110	4	by	by	IN
cord-277535-u283k70i	110	5	oxidative	oxidative	JJ
cord-277535-u283k70i	110	6	metabolism	metabolism	NN
cord-277535-u283k70i	110	7	of	of	IN
cord-277535-u283k70i	110	8	halothane	halothane	NNP
cord-277535-u283k70i	110	9	in	in	IN
cord-277535-u283k70i	110	10	the	the	DT
cord-277535-u283k70i	110	11	liver	liver	NN
cord-277535-u283k70i	110	12	leading	lead	VBG
cord-277535-u283k70i	110	13	to	to	IN
cord-277535-u283k70i	110	14	fever	fever	NN
cord-277535-u283k70i	110	15	,	,	,
cord-277535-u283k70i	110	16	jaundice	jaundice	NN
cord-277535-u283k70i	110	17	,	,	,
cord-277535-u283k70i	110	18	and	and	CC
cord-277535-u283k70i	110	19	dramatically	dramatically	RB
cord-277535-u283k70i	110	20	elevated	elevated	JJ
cord-277535-u283k70i	110	21	serum	serum	NN
cord-277535-u283k70i	110	22	transaminases	transaminase	NNS
cord-277535-u283k70i	110	23	.	.	.
cord-277535-u283k70i	111	1	The	the	DT
cord-277535-u283k70i	111	2	compounds	compound	NNS
cord-277535-u283k70i	111	3	synthesized	synthesize	VBN
cord-277535-u283k70i	111	4	by	by	IN
cord-277535-u283k70i	111	5	oxidation	oxidation	NN
cord-277535-u283k70i	111	6	then	then	RB
cord-277535-u283k70i	111	7	bind	bind	VB
cord-277535-u283k70i	111	8	to	to	IN
cord-277535-u283k70i	111	9	trifluoroacetylate	trifluoroacetylate	JJ
cord-277535-u283k70i	111	10	proteins	protein	NNS
cord-277535-u283k70i	111	11	in	in	IN
cord-277535-u283k70i	111	12	the	the	DT
cord-277535-u283k70i	111	13	hepatic	hepatic	JJ
cord-277535-u283k70i	111	14	endoplasmic	endoplasmic	NN
cord-277535-u283k70i	111	15	reticulum	reticulum	NN
cord-277535-u283k70i	111	16	causing	cause	VBG
cord-277535-u283k70i	111	17	cellular	cellular	JJ
cord-277535-u283k70i	111	18	dysfunction	dysfunction	NN
cord-277535-u283k70i	111	19	,	,	,
cord-277535-u283k70i	111	20	it	-PRON-	PRP
cord-277535-u283k70i	111	21	is	be	VBZ
cord-277535-u283k70i	111	22	thought	think	VBN
cord-277535-u283k70i	111	23	to	to	TO
cord-277535-u283k70i	111	24	occur	occur	VB
cord-277535-u283k70i	111	25	in	in	IN
cord-277535-u283k70i	111	26	genetically	genetically	RB
cord-277535-u283k70i	111	27	predisposed	predispose	VBN
cord-277535-u283k70i	111	28	individuals	individual	NNS
cord-277535-u283k70i	111	29	.	.	.
cord-277535-u283k70i	112	1	The	the	DT
cord-277535-u283k70i	112	2	Committee	Committee	NNP
cord-277535-u283k70i	112	3	on	on	IN
cord-277535-u283k70i	112	4	Safety	Safety	NNP
cord-277535-u283k70i	112	5	of	of	IN
cord-277535-u283k70i	112	6	Medicines	Medicines	NNP
cord-277535-u283k70i	112	7	in	in	IN
cord-277535-u283k70i	112	8	1986	1986	CD
cord-277535-u283k70i	112	9	recommended	recommend	VBD
cord-277535-u283k70i	112	10	the	the	DT
cord-277535-u283k70i	112	11	avoidance	avoidance	NN
cord-277535-u283k70i	112	12	of	of	IN
cord-277535-u283k70i	112	13	halothane	halothane	NNP
cord-277535-u283k70i	112	14	in	in	IN
cord-277535-u283k70i	112	15	patients	patient	NNS
cord-277535-u283k70i	112	16	with	with	IN
cord-277535-u283k70i	112	17	a	a	DT
cord-277535-u283k70i	112	18	history	history	NN
cord-277535-u283k70i	112	19	of	of	IN
cord-277535-u283k70i	112	20	previous	previous	JJ
cord-277535-u283k70i	112	21	adverse	adverse	JJ
cord-277535-u283k70i	112	22	reactions	reaction	NNS
cord-277535-u283k70i	112	23	,	,	,
cord-277535-u283k70i	112	24	those	those	DT
cord-277535-u283k70i	112	25	who	who	WP
cord-277535-u283k70i	112	26	had	have	VBD
cord-277535-u283k70i	112	27	received	receive	VBN
cord-277535-u283k70i	112	28	halothane	halothane	NNP
cord-277535-u283k70i	112	29	within	within	IN
cord-277535-u283k70i	112	30	3	3	CD
cord-277535-u283k70i	112	31	months	month	NNS
cord-277535-u283k70i	112	32	unless	unless	IN
cord-277535-u283k70i	112	33	clinically	clinically	RB
cord-277535-u283k70i	112	34	necessary	necessary	JJ
cord-277535-u283k70i	112	35	,	,	,
cord-277535-u283k70i	112	36	and	and	CC
cord-277535-u283k70i	112	37	those	those	DT
cord-277535-u283k70i	112	38	with	with	IN
cord-277535-u283k70i	112	39	a	a	DT
cord-277535-u283k70i	112	40	history	history	NN
cord-277535-u283k70i	112	41	of	of	IN
cord-277535-u283k70i	112	42	unexplained	unexplained	JJ
cord-277535-u283k70i	112	43	jaundice	jaundice	NN
cord-277535-u283k70i	112	44	or	or	CC
cord-277535-u283k70i	112	45	pyrexia	pyrexia	NN
cord-277535-u283k70i	112	46	following	follow	VBG
cord-277535-u283k70i	112	47	previous	previous	JJ
cord-277535-u283k70i	112	48	halothane	halothane	NNP
cord-277535-u283k70i	112	49	anaesthesia	anaesthesia	NNP
cord-277535-u283k70i	112	50	.	.	.
cord-277535-u283k70i	113	1	IV	IV	NNP
cord-277535-u283k70i	113	2	Anaesthetics	anaesthetic	NNS
cord-277535-u283k70i	113	3	:	:	:
cord-277535-u283k70i	113	4	the	the	DT
cord-277535-u283k70i	113	5	induction	induction	NN
cord-277535-u283k70i	113	6	agents	agent	NNS
cord-277535-u283k70i	113	7	have	have	VBP
cord-277535-u283k70i	113	8	a	a	DT
cord-277535-u283k70i	113	9	marked	marked	JJ
cord-277535-u283k70i	113	10	effect	effect	NN
cord-277535-u283k70i	113	11	on	on	IN
cord-277535-u283k70i	113	12	haemodynamics	haemodynamic	NNS
cord-277535-u283k70i	113	13	and	and	CC
cord-277535-u283k70i	113	14	may	may	MD
cord-277535-u283k70i	113	15	cause	cause	VB
cord-277535-u283k70i	113	16	sudden	sudden	JJ
cord-277535-u283k70i	113	17	precipitious	precipitious	JJ
cord-277535-u283k70i	113	18	fall	fall	NN
cord-277535-u283k70i	113	19	in	in	IN
cord-277535-u283k70i	113	20	blood	blood	NN
cord-277535-u283k70i	113	21	pressure	pressure	NN
cord-277535-u283k70i	113	22	.	.	.
cord-277535-u283k70i	114	1	In	in	IN
cord-277535-u283k70i	114	2	clinical	clinical	JJ
cord-277535-u283k70i	114	3	practice	practice	NN
cord-277535-u283k70i	114	4	a	a	DT
cord-277535-u283k70i	114	5	standard	standard	JJ
cord-277535-u283k70i	114	6	induction	induction	NN
cord-277535-u283k70i	114	7	dose	dose	NN
cord-277535-u283k70i	114	8	need	need	NN
cord-277535-u283k70i	114	9	not	not	RB
cord-277535-u283k70i	114	10	be	be	VB
cord-277535-u283k70i	114	11	altered	alter	VBN
cord-277535-u283k70i	114	12	.	.	.
cord-277535-u283k70i	115	1	However	however	RB
cord-277535-u283k70i	115	2	they	-PRON-	PRP
cord-277535-u283k70i	115	3	should	should	MD
cord-277535-u283k70i	115	4	be	be	VB
cord-277535-u283k70i	115	5	titrated	titrate	VBN
cord-277535-u283k70i	115	6	slowly	slowly	RB
cord-277535-u283k70i	115	7	to	to	TO
cord-277535-u283k70i	115	8	effect	effect	VB
cord-277535-u283k70i	115	9	.	.	.
cord-277535-u283k70i	116	1	There	there	EX
cord-277535-u283k70i	116	2	are	be	VBP
cord-277535-u283k70i	116	3	no	no	DT
cord-277535-u283k70i	116	4	current	current	JJ
cord-277535-u283k70i	116	5	recommendations	recommendation	NNS
cord-277535-u283k70i	116	6	on	on	IN
cord-277535-u283k70i	116	7	the	the	DT
cord-277535-u283k70i	116	8	use	use	NN
cord-277535-u283k70i	116	9	of	of	IN
cord-277535-u283k70i	116	10	TIVA	TIVA	NNP
cord-277535-u283k70i	117	1	(	(	-LRB-
cord-277535-u283k70i	117	2	Total	Total	NNP
cord-277535-u283k70i	117	3	Intravenous	Intravenous	NNP
cord-277535-u283k70i	117	4	Anaesthesia	Anaesthesia	NNP
cord-277535-u283k70i	117	5	)	)	-RRB-
cord-277535-u283k70i	117	6	in	in	IN
cord-277535-u283k70i	117	7	patients	patient	NNS
cord-277535-u283k70i	117	8	with	with	IN
cord-277535-u283k70i	117	9	liver	liver	NN
cord-277535-u283k70i	117	10	disease	disease	NN
cord-277535-u283k70i	117	11	.	.	.
cord-277535-u283k70i	118	1	Research	research	NN
cord-277535-u283k70i	118	2	is	be	VBZ
cord-277535-u283k70i	118	3	sparse	sparse	JJ
cord-277535-u283k70i	118	4	and	and	CC
cord-277535-u283k70i	118	5	conflicting	conflicting	JJ
cord-277535-u283k70i	118	6	.	.	.
cord-277535-u283k70i	119	1	Some	some	DT
cord-277535-u283k70i	119	2	earlier	early	JJR
cord-277535-u283k70i	119	3	reports	report	NNS
cord-277535-u283k70i	119	4	suggested	suggest	VBD
cord-277535-u283k70i	119	5	that	that	IN
cord-277535-u283k70i	119	6	inhalational	inhalational	JJ
cord-277535-u283k70i	119	7	anaesthesia	anaesthesia	NN
cord-277535-u283k70i	119	8	results	result	NNS
cord-277535-u283k70i	119	9	in	in	IN
cord-277535-u283k70i	119	10	smaller	small	JJR
cord-277535-u283k70i	119	11	elevation	elevation	NN
cord-277535-u283k70i	119	12	of	of	IN
cord-277535-u283k70i	119	13	liver	liver	NN
cord-277535-u283k70i	119	14	enzymes	enzyme	NNS
cord-277535-u283k70i	119	15	than	than	IN
cord-277535-u283k70i	119	16	TIVA	TIVA	NNP
cord-277535-u283k70i	119	17	with	with	IN
cord-277535-u283k70i	119	18	Propofol	propofol	NN
cord-277535-u283k70i	119	19	-	-	HYPH
cord-277535-u283k70i	119	20	Fentanyl	fentanyl	NN
cord-277535-u283k70i	119	21	.	.	.
cord-277535-u283k70i	120	1	16	16	CD
cord-277535-u283k70i	121	1	A	a	DT
cord-277535-u283k70i	121	2	more	more	RBR
cord-277535-u283k70i	121	3	recent	recent	JJ
cord-277535-u283k70i	121	4	study	study	NN
cord-277535-u283k70i	121	5	however	however	RB
cord-277535-u283k70i	121	6	suggested	suggest	VBD
cord-277535-u283k70i	121	7	slightly	slightly	RB
cord-277535-u283k70i	121	8	lower	low	JJR
cord-277535-u283k70i	121	9	rate	rate	NN
cord-277535-u283k70i	121	10	of	of	IN
cord-277535-u283k70i	121	11	elevation	elevation	NN
cord-277535-u283k70i	121	12	in	in	IN
cord-277535-u283k70i	121	13	LFT	LFT	NNP
cord-277535-u283k70i	121	14	after	after	IN
cord-277535-u283k70i	121	15	using	use	VBG
cord-277535-u283k70i	121	16	TIVA	TIVA	NNP
cord-277535-u283k70i	121	17	.	.	.
cord-277535-u283k70i	122	1	17	17	CD
cord-277535-u283k70i	122	2	Opiates	Opiates	NNP
cord-277535-u283k70i	122	3	Morphine	Morphine	NNP
cord-277535-u283k70i	122	4	is	be	VBZ
cord-277535-u283k70i	122	5	metabolized	metabolize	VBN
cord-277535-u283k70i	122	6	by	by	IN
cord-277535-u283k70i	122	7	the	the	DT
cord-277535-u283k70i	122	8	liver	liver	NN
cord-277535-u283k70i	122	9	to	to	IN
cord-277535-u283k70i	122	10	active	active	JJ
cord-277535-u283k70i	122	11	metabolite	metabolite	NN
cord-277535-u283k70i	122	12	morphine-6-glucoronide	morphine-6-glucoronide	NNP
cord-277535-u283k70i	122	13	which	which	WDT
cord-277535-u283k70i	122	14	has	have	VBZ
cord-277535-u283k70i	122	15	potent	potent	JJ
cord-277535-u283k70i	122	16	analgesic	analgesic	JJ
cord-277535-u283k70i	122	17	properties	property	NNS
cord-277535-u283k70i	122	18	,	,	,
cord-277535-u283k70i	122	19	and	and	CC
cord-277535-u283k70i	122	20	morphine-3-glucuronide	morphine-3-glucuronide	NNP
cord-277535-u283k70i	122	21	,	,	,
cord-277535-u283k70i	122	22	which	which	WDT
cord-277535-u283k70i	122	23	has	have	VBZ
cord-277535-u283k70i	122	24	no	no	DT
cord-277535-u283k70i	122	25	analgesic	analgesic	JJ
cord-277535-u283k70i	122	26	properties	property	NNS
cord-277535-u283k70i	122	27	but	but	CC
cord-277535-u283k70i	122	28	has	have	VBZ
cord-277535-u283k70i	122	29	adverse	adverse	JJ
cord-277535-u283k70i	122	30	neurotoxic	neurotoxic	JJ
cord-277535-u283k70i	122	31	side	side	NN
cord-277535-u283k70i	122	32	effects	effect	NNS
cord-277535-u283k70i	122	33	such	such	JJ
cord-277535-u283k70i	122	34	as	as	IN
cord-277535-u283k70i	122	35	confusion	confusion	NN
cord-277535-u283k70i	122	36	and	and	CC
cord-277535-u283k70i	122	37	respiratory	respiratory	JJ
cord-277535-u283k70i	122	38	depression	depression	NN
cord-277535-u283k70i	122	39	.	.	.
cord-277535-u283k70i	123	1	As	as	IN
cord-277535-u283k70i	123	2	both	both	DT
cord-277535-u283k70i	123	3	metabolites	metabolite	NNS
cord-277535-u283k70i	123	4	are	be	VBP
cord-277535-u283k70i	123	5	excreted	excrete	VBN
cord-277535-u283k70i	123	6	renally	renally	NN
cord-277535-u283k70i	123	7	,	,	,
cord-277535-u283k70i	123	8	they	-PRON-	PRP
cord-277535-u283k70i	123	9	accumulate	accumulate	VBP
cord-277535-u283k70i	123	10	in	in	IN
cord-277535-u283k70i	123	11	renal	renal	JJ
cord-277535-u283k70i	123	12	failure	failure	NN
cord-277535-u283k70i	123	13	.	.	.
cord-277535-u283k70i	124	1	In	in	IN
cord-277535-u283k70i	124	2	liver	liver	NN
cord-277535-u283k70i	124	3	failure	failure	NN
cord-277535-u283k70i	124	4	morphine	morphine	NN
cord-277535-u283k70i	124	5	itself	-PRON-	PRP
cord-277535-u283k70i	124	6	may	may	MD
cord-277535-u283k70i	124	7	accumulate	accumulate	VB
cord-277535-u283k70i	124	8	as	as	IN
cord-277535-u283k70i	124	9	extraction	extraction	NN
cord-277535-u283k70i	124	10	ratio	ratio	NN
cord-277535-u283k70i	124	11	is	be	VBZ
cord-277535-u283k70i	124	12	reduced	reduce	VBN
cord-277535-u283k70i	124	13	thereby	thereby	RB
cord-277535-u283k70i	124	14	enhancing	enhance	VBG
cord-277535-u283k70i	124	15	further	far	RBR
cord-277535-u283k70i	124	16	the	the	DT
cord-277535-u283k70i	124	17	effect	effect	NN
cord-277535-u283k70i	124	18	of	of	IN
cord-277535-u283k70i	124	19	morphine	morphine	NN
cord-277535-u283k70i	124	20	.	.	.
cord-277535-u283k70i	125	1	13	13	CD
cord-277535-u283k70i	126	1	Therefore	therefore	RB
cord-277535-u283k70i	126	2	dose	dose	NN
cord-277535-u283k70i	126	3	of	of	IN
cord-277535-u283k70i	126	4	morphine	morphine	NN
cord-277535-u283k70i	126	5	should	should	MD
cord-277535-u283k70i	126	6	be	be	VB
cord-277535-u283k70i	126	7	reduced	reduce	VBN
cord-277535-u283k70i	126	8	.	.	.
cord-277535-u283k70i	127	1	The	the	DT
cord-277535-u283k70i	127	2	same	same	JJ
cord-277535-u283k70i	127	3	is	be	VBZ
cord-277535-u283k70i	127	4	true	true	JJ
cord-277535-u283k70i	127	5	of	of	IN
cord-277535-u283k70i	127	6	fentanyl	fentanyl	NN
cord-277535-u283k70i	127	7	and	and	CC
cord-277535-u283k70i	127	8	alfentanil	alfentanil	NN
cord-277535-u283k70i	127	9	dose	dose	NN
cord-277535-u283k70i	127	10	,	,	,
cord-277535-u283k70i	127	11	as	as	IN
cord-277535-u283k70i	127	12	although	although	IN
cord-277535-u283k70i	127	13	there	there	EX
cord-277535-u283k70i	127	14	is	be	VBZ
cord-277535-u283k70i	127	15	no	no	DT
cord-277535-u283k70i	127	16	active	active	JJ
cord-277535-u283k70i	127	17	metabolite	metabolite	NN
cord-277535-u283k70i	127	18	they	-PRON-	PRP
cord-277535-u283k70i	127	19	also	also	RB
cord-277535-u283k70i	127	20	rely	rely	VBP
cord-277535-u283k70i	127	21	on	on	IN
cord-277535-u283k70i	127	22	hepatic	hepatic	JJ
cord-277535-u283k70i	127	23	metabolism	metabolism	NN
cord-277535-u283k70i	127	24	.	.	.
cord-277535-u283k70i	128	1	Remifentanil	Remifentanil	NNP
cord-277535-u283k70i	128	2	may	may	MD
cord-277535-u283k70i	128	3	be	be	VB
cord-277535-u283k70i	128	4	good	good	JJ
cord-277535-u283k70i	128	5	choice	choice	NN
cord-277535-u283k70i	128	6	as	as	IN
cord-277535-u283k70i	128	7	its	-PRON-	PRP$
cord-277535-u283k70i	128	8	metabolism	metabolism	NN
cord-277535-u283k70i	128	9	is	be	VBZ
cord-277535-u283k70i	128	10	by	by	IN
cord-277535-u283k70i	128	11	plasma	plasma	NN
cord-277535-u283k70i	128	12	esterases	esterase	NNS
cord-277535-u283k70i	128	13	and	and	CC
cord-277535-u283k70i	128	14	it	-PRON-	PRP
cord-277535-u283k70i	128	15	has	have	VBZ
cord-277535-u283k70i	128	16	no	no	DT
cord-277535-u283k70i	128	17	active	active	JJ
cord-277535-u283k70i	128	18	metabolites	metabolite	NNS
cord-277535-u283k70i	128	19	.	.	.
cord-277535-u283k70i	129	1	A	a	DT
cord-277535-u283k70i	129	2	review	review	NN
cord-277535-u283k70i	129	3	of	of	IN
cord-277535-u283k70i	129	4	pain	pain	NN
cord-277535-u283k70i	129	5	management	management	NN
cord-277535-u283k70i	129	6	in	in	IN
cord-277535-u283k70i	129	7	patients	patient	NNS
cord-277535-u283k70i	129	8	with	with	IN
cord-277535-u283k70i	129	9	liver	liver	NN
cord-277535-u283k70i	129	10	disease	disease	NN
cord-277535-u283k70i	129	11	by	by	IN
cord-277535-u283k70i	129	12	the	the	DT
cord-277535-u283k70i	129	13	American	American	NNP
cord-277535-u283k70i	129	14	Association	Association	NNP
cord-277535-u283k70i	129	15	for	for	IN
cord-277535-u283k70i	129	16	Study	Study	NNP
cord-277535-u283k70i	129	17	of	of	IN
cord-277535-u283k70i	129	18	Liver	Liver	NNP
cord-277535-u283k70i	129	19	Diseases	Diseases	NNPS
cord-277535-u283k70i	129	20	(	(	-LRB-
cord-277535-u283k70i	129	21	AALSD	AALSD	NNP
cord-277535-u283k70i	129	22	)	)	-RRB-
cord-277535-u283k70i	129	23	in	in	IN
cord-277535-u283k70i	129	24	2018	2018	CD
cord-277535-u283k70i	129	25	states	state	NNS
cord-277535-u283k70i	129	26	in	in	IN
cord-277535-u283k70i	129	27	general	general	JJ
cord-277535-u283k70i	129	28	most	most	JJS
cord-277535-u283k70i	129	29	opioids	opioid	NNS
cord-277535-u283k70i	129	30	have	have	VBP
cord-277535-u283k70i	129	31	prolonged	prolong	VBN
cord-277535-u283k70i	129	32	half	half	JJ
cord-277535-u283k70i	129	33	life	life	NN
cord-277535-u283k70i	129	34	.	.	.
cord-277535-u283k70i	130	1	Their	-PRON-	PRP$
cord-277535-u283k70i	130	2	recommendations	recommendation	NNS
cord-277535-u283k70i	130	3	include	include	VBP
cord-277535-u283k70i	130	4	increase	increase	VB
cord-277535-u283k70i	130	5	the	the	DT
cord-277535-u283k70i	130	6	dosing	dose	VBG
cord-277535-u283k70i	130	7	intervals	interval	NNS
cord-277535-u283k70i	130	8	(	(	-LRB-
cord-277535-u283k70i	130	9	6e12hr	6e12hr	CD
cord-277535-u283k70i	130	10	)	)	-RRB-
cord-277535-u283k70i	130	11	and	and	CC
cord-277535-u283k70i	130	12	using	use	VBG
cord-277535-u283k70i	130	13	immediate	immediate	JJ
cord-277535-u283k70i	130	14	release	release	NN
cord-277535-u283k70i	130	15	preparations	preparation	NNS
cord-277535-u283k70i	130	16	over	over	IN
cord-277535-u283k70i	130	17	extended	extended	JJ
cord-277535-u283k70i	130	18	release	release	NN
cord-277535-u283k70i	130	19	18	18	CD
cord-277535-u283k70i	131	1	In	in	IN
cord-277535-u283k70i	131	2	July	July	NNP
cord-277535-u283k70i	131	3	2013	2013	CD
cord-277535-u283k70i	131	4	the	the	DT
cord-277535-u283k70i	131	5	Medicine	Medicine	NNP
cord-277535-u283k70i	131	6	and	and	CC
cord-277535-u283k70i	131	7	Healthcare	Healthcare	NNP
cord-277535-u283k70i	131	8	products	product	NNS
cord-277535-u283k70i	131	9	Regulatory	Regulatory	NNP
cord-277535-u283k70i	131	10	Agency	Agency	NNP
cord-277535-u283k70i	131	11	(	(	-LRB-
cord-277535-u283k70i	131	12	MHRA	MHRA	NNP
cord-277535-u283k70i	131	13	)	)	-RRB-
cord-277535-u283k70i	131	14	produced	produce	VBD
cord-277535-u283k70i	131	15	a	a	DT
cord-277535-u283k70i	131	16	drug	drug	NN
cord-277535-u283k70i	131	17	safety	safety	NN
cord-277535-u283k70i	131	18	update	update	NN
cord-277535-u283k70i	131	19	that	that	WDT
cord-277535-u283k70i	131	20	restricted	restrict	VBD
cord-277535-u283k70i	131	21	the	the	DT
cord-277535-u283k70i	131	22	use	use	NN
cord-277535-u283k70i	131	23	of	of	IN
cord-277535-u283k70i	131	24	codeine	codeine	NN
cord-277535-u283k70i	131	25	in	in	IN
cord-277535-u283k70i	131	26	children	child	NNS
cord-277535-u283k70i	131	27	.	.	.
cord-277535-u283k70i	132	1	19	19	CD
cord-277535-u283k70i	133	1	This	this	DT
cord-277535-u283k70i	133	2	was	be	VBD
cord-277535-u283k70i	133	3	prompted	prompt	VBN
cord-277535-u283k70i	133	4	by	by	IN
cord-277535-u283k70i	133	5	case	case	NN
cord-277535-u283k70i	133	6	reports	report	NNS
cord-277535-u283k70i	133	7	of	of	IN
cord-277535-u283k70i	133	8	four	four	CD
cord-277535-u283k70i	133	9	children	child	NNS
cord-277535-u283k70i	133	10	suffered	suffer	VBD
cord-277535-u283k70i	133	11	serious	serious	JJ
cord-277535-u283k70i	133	12	harm	harm	NN
cord-277535-u283k70i	133	13	following	follow	VBG
cord-277535-u283k70i	133	14	the	the	DT
cord-277535-u283k70i	133	15	administration	administration	NN
cord-277535-u283k70i	133	16	of	of	IN
cord-277535-u283k70i	133	17	codeine	codeine	NNP
cord-277535-u283k70i	133	18	in	in	IN
cord-277535-u283k70i	133	19	the	the	DT
cord-277535-u283k70i	133	20	immediate	immediate	JJ
cord-277535-u283k70i	133	21	post	post	JJ
cord-277535-u283k70i	133	22	-	-	JJ
cord-277535-u283k70i	133	23	operative	operative	JJ
cord-277535-u283k70i	133	24	period	period	NN
cord-277535-u283k70i	133	25	.	.	.
cord-277535-u283k70i	134	1	Codeine	Codeine	NNP
cord-277535-u283k70i	134	2	should	should	MD
cord-277535-u283k70i	134	3	only	only	RB
cord-277535-u283k70i	134	4	be	be	VB
cord-277535-u283k70i	134	5	used	use	VBN
cord-277535-u283k70i	134	6	to	to	TO
cord-277535-u283k70i	134	7	relieve	relieve	VB
cord-277535-u283k70i	134	8	acute	acute	JJ
cord-277535-u283k70i	134	9	moderate	moderate	JJ
cord-277535-u283k70i	134	10	pain	pain	NN
cord-277535-u283k70i	134	11	in	in	IN
cord-277535-u283k70i	134	12	children	child	NNS
cord-277535-u283k70i	134	13	older	old	JJR
cord-277535-u283k70i	134	14	than	than	IN
cord-277535-u283k70i	134	15	12	12	CD
cord-277535-u283k70i	134	16	years	year	NNS
cord-277535-u283k70i	134	17	and	and	CC
cord-277535-u283k70i	134	18	only	only	RB
cord-277535-u283k70i	134	19	if	if	IN
cord-277535-u283k70i	134	20	it	-PRON-	PRP
cord-277535-u283k70i	134	21	can	can	MD
cord-277535-u283k70i	134	22	not	not	RB
cord-277535-u283k70i	134	23	be	be	VB
cord-277535-u283k70i	134	24	relieved	relieve	VBN
cord-277535-u283k70i	134	25	by	by	IN
cord-277535-u283k70i	134	26	other	other	JJ
cord-277535-u283k70i	134	27	painkillers	painkiller	NNS
cord-277535-u283k70i	134	28	such	such	JJ
cord-277535-u283k70i	134	29	as	as	IN
cord-277535-u283k70i	134	30	paracetamol	paracetamol	JJ
cord-277535-u283k70i	134	31	or	or	CC
cord-277535-u283k70i	134	32	ibuprofen	ibuprofen	NN
cord-277535-u283k70i	134	33	alone	alone	RB
cord-277535-u283k70i	134	34	.	.	.
cord-277535-u283k70i	135	1	A	a	DT
cord-277535-u283k70i	135	2	significant	significant	JJ
cord-277535-u283k70i	135	3	risk	risk	NN
cord-277535-u283k70i	135	4	of	of	IN
cord-277535-u283k70i	135	5	serious	serious	JJ
cord-277535-u283k70i	135	6	and	and	CC
cord-277535-u283k70i	135	7	life	life	NN
cord-277535-u283k70i	135	8	-	-	HYPH
cord-277535-u283k70i	135	9	threatening	threaten	VBG
cord-277535-u283k70i	135	10	adverse	adverse	JJ
cord-277535-u283k70i	135	11	reactions	reaction	NNS
cord-277535-u283k70i	135	12	has	have	VBZ
cord-277535-u283k70i	135	13	been	be	VBN
cord-277535-u283k70i	135	14	identified	identify	VBN
cord-277535-u283k70i	135	15	in	in	IN
cord-277535-u283k70i	135	16	children	child	NNS
cord-277535-u283k70i	135	17	with	with	IN
cord-277535-u283k70i	135	18	obstructive	obstructive	JJ
cord-277535-u283k70i	135	19	sleep	sleep	NN
cord-277535-u283k70i	135	20	apnoea	apnoea	NN
cord-277535-u283k70i	135	21	who	who	WP
cord-277535-u283k70i	135	22	received	receive	VBD
cord-277535-u283k70i	135	23	codeine	codeine	NN
cord-277535-u283k70i	135	24	after	after	IN
cord-277535-u283k70i	135	25	tonsillectomy	tonsillectomy	NN
cord-277535-u283k70i	135	26	or	or	CC
cord-277535-u283k70i	135	27	adenoidectomy	adenoidectomy	NN
cord-277535-u283k70i	135	28	(	(	-LRB-
cord-277535-u283k70i	135	29	or	or	CC
cord-277535-u283k70i	135	30	both	both	DT
cord-277535-u283k70i	135	31	)	)	-RRB-
cord-277535-u283k70i	135	32	.	.	.
cord-277535-u283k70i	136	1	Codeine	codeine	NN
cord-277535-u283k70i	136	2	is	be	VBZ
cord-277535-u283k70i	136	3	now	now	RB
cord-277535-u283k70i	136	4	contraindicated	contraindicate	VBN
cord-277535-u283k70i	136	5	in	in	IN
cord-277535-u283k70i	136	6	all	all	DT
cord-277535-u283k70i	136	7	children	child	NNS
cord-277535-u283k70i	136	8	younger	young	JJR
cord-277535-u283k70i	136	9	than	than	IN
cord-277535-u283k70i	136	10	18	18	CD
cord-277535-u283k70i	136	11	years	year	NNS
cord-277535-u283k70i	136	12	who	who	WP
cord-277535-u283k70i	136	13	undergo	undergo	VBP
cord-277535-u283k70i	136	14	these	these	DT
cord-277535-u283k70i	136	15	procedures	procedure	NNS
cord-277535-u283k70i	136	16	for	for	IN
cord-277535-u283k70i	136	17	obstructive	obstructive	JJ
cord-277535-u283k70i	136	18	sleep	sleep	NN
cord-277535-u283k70i	136	19	apnoea	apnoea	NN
cord-277535-u283k70i	136	20	.	.	.
cord-277535-u283k70i	137	1	Codeine	Codeine	NNP
cord-277535-u283k70i	137	2	is	be	VBZ
cord-277535-u283k70i	137	3	converted	convert	VBN
cord-277535-u283k70i	137	4	to	to	IN
cord-277535-u283k70i	137	5	morphine	morphine	NN
cord-277535-u283k70i	137	6	in	in	IN
cord-277535-u283k70i	137	7	the	the	DT
cord-277535-u283k70i	137	8	liver	liver	NN
cord-277535-u283k70i	137	9	by	by	IN
cord-277535-u283k70i	137	10	the	the	DT
cord-277535-u283k70i	137	11	CYP2D6	cyp2d6	JJ
cord-277535-u283k70i	137	12	enzyme	enzyme	NN
cord-277535-u283k70i	137	13	.	.	.
cord-277535-u283k70i	138	1	The	the	DT
cord-277535-u283k70i	138	2	extent	extent	NN
cord-277535-u283k70i	138	3	of	of	IN
cord-277535-u283k70i	138	4	conversion	conversion	NN
cord-277535-u283k70i	138	5	of	of	IN
cord-277535-u283k70i	138	6	codeine	codeine	NN
cord-277535-u283k70i	138	7	to	to	IN
cord-277535-u283k70i	138	8	morphine	morphine	NN
cord-277535-u283k70i	138	9	depends	depend	VBZ
cord-277535-u283k70i	138	10	on	on	IN
cord-277535-u283k70i	138	11	genetic	genetic	JJ
cord-277535-u283k70i	138	12	variations	variation	NNS
cord-277535-u283k70i	138	13	of	of	IN
cord-277535-u283k70i	138	14	CYP2D6	CYP2D6	NNP
cord-277535-u283k70i	138	15	.	.	.
cord-277535-u283k70i	139	1	People	People	NNS
cord-277535-u283k70i	139	2	can	can	MD
cord-277535-u283k70i	139	3	be	be	VB
cord-277535-u283k70i	139	4	classified	classify	VBN
cord-277535-u283k70i	139	5	as	as	IN
cord-277535-u283k70i	139	6	:	:	:
cord-277535-u283k70i	139	7	poor	poor	JJ
cord-277535-u283k70i	139	8	;	;	:
cord-277535-u283k70i	139	9	intermediate	intermediate	JJ
cord-277535-u283k70i	139	10	;	;	:
cord-277535-u283k70i	139	11	extensive	extensive	JJ
cord-277535-u283k70i	139	12	;	;	:
cord-277535-u283k70i	139	13	or	or	CC
cord-277535-u283k70i	139	14	ultra	ultra	JJ
cord-277535-u283k70i	139	15	-	-	JJ
cord-277535-u283k70i	139	16	rapid	rapid	JJ
cord-277535-u283k70i	139	17	metabolisers	metaboliser	NNS
cord-277535-u283k70i	139	18	.	.	.
cord-277535-u283k70i	140	1	Poor	poor	JJ
cord-277535-u283k70i	140	2	metabolisers	metaboliser	NNS
cord-277535-u283k70i	140	3	convert	convert	VBP
cord-277535-u283k70i	140	4	very	very	RB
cord-277535-u283k70i	140	5	little	little	JJ
cord-277535-u283k70i	140	6	codeine	codeine	NN
cord-277535-u283k70i	140	7	into	into	IN
cord-277535-u283k70i	140	8	morphine	morphine	NN
cord-277535-u283k70i	140	9	and	and	CC
cord-277535-u283k70i	140	10	therefore	therefore	RB
cord-277535-u283k70i	140	11	have	have	VBP
cord-277535-u283k70i	140	12	little	little	JJ
cord-277535-u283k70i	140	13	or	or	CC
cord-277535-u283k70i	140	14	no	no	DT
cord-277535-u283k70i	140	15	pain	pain	NN
cord-277535-u283k70i	140	16	relief	relief	NN
cord-277535-u283k70i	140	17	,	,	,
cord-277535-u283k70i	140	18	ultra	ultra	JJ
cord-277535-u283k70i	140	19	-	-	JJ
cord-277535-u283k70i	140	20	rapid	rapid	JJ
cord-277535-u283k70i	140	21	metabolisers	metaboliser	NNS
cord-277535-u283k70i	140	22	or	or	CC
cord-277535-u283k70i	140	23	extensive	extensive	JJ
cord-277535-u283k70i	140	24	metabolisers	metaboliser	NNS
cord-277535-u283k70i	140	25	have	have	VBP
cord-277535-u283k70i	140	26	an	an	DT
cord-277535-u283k70i	140	27	excessive	excessive	JJ
cord-277535-u283k70i	140	28	amount	amount	NN
cord-277535-u283k70i	140	29	of	of	IN
cord-277535-u283k70i	140	30	morphine	morphine	NN
cord-277535-u283k70i	140	31	in	in	IN
cord-277535-u283k70i	140	32	their	-PRON-	PRP$
cord-277535-u283k70i	140	33	blood	blood	NN
cord-277535-u283k70i	140	34	following	follow	VBG
cord-277535-u283k70i	140	35	ingestion	ingestion	NN
cord-277535-u283k70i	140	36	of	of	IN
cord-277535-u283k70i	140	37	codeine	codeine	NN
cord-277535-u283k70i	140	38	.	.	.
cord-277535-u283k70i	141	1	Ethnic	ethnic	JJ
cord-277535-u283k70i	141	2	origin	origin	NN
cord-277535-u283k70i	141	3	is	be	VBZ
cord-277535-u283k70i	141	4	an	an	DT
cord-277535-u283k70i	141	5	important	important	JJ
cord-277535-u283k70i	141	6	factor	factor	NN
cord-277535-u283k70i	141	7	in	in	IN
cord-277535-u283k70i	141	8	genetic	genetic	JJ
cord-277535-u283k70i	141	9	variability	variability	NN
cord-277535-u283k70i	141	10	.	.	.
cord-277535-u283k70i	142	1	Up	up	IN
cord-277535-u283k70i	142	2	to	to	TO
cord-277535-u283k70i	142	3	10	10	CD
cord-277535-u283k70i	142	4	%	%	NN
cord-277535-u283k70i	142	5	of	of	IN
cord-277535-u283k70i	142	6	Caucasians	Caucasians	NNPS
cord-277535-u283k70i	142	7	are	be	VBP
cord-277535-u283k70i	142	8	poor	poor	JJ
cord-277535-u283k70i	142	9	metabolisers	metaboliser	NNS
cord-277535-u283k70i	142	10	whereas	whereas	IN
cord-277535-u283k70i	142	11	up	up	IN
cord-277535-u283k70i	142	12	to	to	TO
cord-277535-u283k70i	142	13	29	29	CD
cord-277535-u283k70i	142	14	%	%	NN
cord-277535-u283k70i	142	15	of	of	IN
cord-277535-u283k70i	142	16	patients	patient	NNS
cord-277535-u283k70i	142	17	of	of	IN
cord-277535-u283k70i	142	18	African	african	JJ
cord-277535-u283k70i	142	19	origin	origin	NN
cord-277535-u283k70i	142	20	may	may	MD
cord-277535-u283k70i	142	21	be	be	VB
cord-277535-u283k70i	142	22	ultra	ultra	JJ
cord-277535-u283k70i	142	23	-	-	JJ
cord-277535-u283k70i	142	24	rapid	rapid	JJ
cord-277535-u283k70i	142	25	metabolisers	metaboliser	NNS
cord-277535-u283k70i	142	26	.	.	.
cord-277535-u283k70i	143	1	(	(	-LRB-
cord-277535-u283k70i	143	2	Table	table	NN
cord-277535-u283k70i	143	3	2	2	CD
cord-277535-u283k70i	143	4	)	)	-RRB-
cord-277535-u283k70i	143	5	.	.	.
cord-277535-u283k70i	144	1	This	this	DT
cord-277535-u283k70i	144	2	genetic	genetic	JJ
cord-277535-u283k70i	144	3	variability	variability	NN
cord-277535-u283k70i	144	4	leads	lead	VBZ
cord-277535-u283k70i	144	5	to	to	IN
cord-277535-u283k70i	144	6	different	different	JJ
cord-277535-u283k70i	144	7	plasma	plasma	NN
cord-277535-u283k70i	144	8	morphine	morphine	NN
cord-277535-u283k70i	144	9	concentrations	concentration	NNS
cord-277535-u283k70i	144	10	in	in	IN
cord-277535-u283k70i	144	11	patients	patient	NNS
cord-277535-u283k70i	144	12	leading	lead	VBG
cord-277535-u283k70i	144	13	to	to	IN
cord-277535-u283k70i	144	14	different	different	JJ
cord-277535-u283k70i	144	15	analgesic	analgesic	JJ
cord-277535-u283k70i	144	16	effects	effect	NNS
cord-277535-u283k70i	144	17	as	as	RB
cord-277535-u283k70i	144	18	well	well	RB
cord-277535-u283k70i	144	19	as	as	IN
cord-277535-u283k70i	144	20	side	side	NN
cord-277535-u283k70i	144	21	effects	effect	NNS
cord-277535-u283k70i	144	22	including	include	VBG
cord-277535-u283k70i	144	23	respiratory	respiratory	JJ
cord-277535-u283k70i	144	24	depression	depression	NN
cord-277535-u283k70i	144	25	.	.	.
cord-277535-u283k70i	145	1	Codeine	codeine	NN
cord-277535-u283k70i	145	2	is	be	VBZ
cord-277535-u283k70i	145	3	contraindicated	contraindicated	JJ
cord-277535-u283k70i	145	4	in	in	IN
cord-277535-u283k70i	145	5	all	all	DT
cord-277535-u283k70i	145	6	patients	patient	NNS
cord-277535-u283k70i	145	7	of	of	IN
cord-277535-u283k70i	145	8	any	any	DT
cord-277535-u283k70i	145	9	age	age	NN
cord-277535-u283k70i	145	10	known	know	VBN
cord-277535-u283k70i	145	11	to	to	TO
cord-277535-u283k70i	145	12	be	be	VB
cord-277535-u283k70i	145	13	CYP2D6	cyp2d6	JJ
cord-277535-u283k70i	145	14	ultra	ultra	JJ
cord-277535-u283k70i	145	15	-	-	JJ
cord-277535-u283k70i	145	16	rapid	rapid	JJ
cord-277535-u283k70i	145	17	metabolisers	metaboliser	NNS
cord-277535-u283k70i	145	18	and	and	CC
cord-277535-u283k70i	145	19	should	should	MD
cord-277535-u283k70i	145	20	not	not	RB
cord-277535-u283k70i	145	21	be	be	VB
cord-277535-u283k70i	145	22	used	use	VBN
cord-277535-u283k70i	145	23	by	by	IN
cord-277535-u283k70i	145	24	breastfeeding	breastfeed	VBG
cord-277535-u283k70i	145	25	mothers	mother	NNS
cord-277535-u283k70i	145	26	because	because	IN
cord-277535-u283k70i	145	27	it	-PRON-	PRP
cord-277535-u283k70i	145	28	can	can	MD
cord-277535-u283k70i	145	29	pass	pass	VB
cord-277535-u283k70i	145	30	to	to	IN
cord-277535-u283k70i	145	31	the	the	DT
cord-277535-u283k70i	145	32	baby	baby	NN
cord-277535-u283k70i	145	33	through	through	IN
cord-277535-u283k70i	145	34	breast	breast	NN
cord-277535-u283k70i	145	35	milk	milk	NN
cord-277535-u283k70i	145	36	and	and	CC
cord-277535-u283k70i	145	37	potentially	potentially	RB
cord-277535-u283k70i	145	38	cause	cause	VB
cord-277535-u283k70i	145	39	harm	harm	NN
cord-277535-u283k70i	145	40	.	.	.
cord-277535-u283k70i	146	1	NSAIDS	NSAIDS	NNP
cord-277535-u283k70i	146	2	are	be	VBP
cord-277535-u283k70i	146	3	contraindicated	contraindicated	JJ
cord-277535-u283k70i	146	4	for	for	IN
cord-277535-u283k70i	146	5	systemic	systemic	JJ
cord-277535-u283k70i	146	6	use	use	NN
cord-277535-u283k70i	146	7	in	in	IN
cord-277535-u283k70i	146	8	most	most	JJS
cord-277535-u283k70i	146	9	liver	liver	NN
cord-277535-u283k70i	146	10	disease	disease	NN
cord-277535-u283k70i	146	11	patients	patient	NNS
cord-277535-u283k70i	146	12	,	,	,
cord-277535-u283k70i	146	13	because	because	IN
cord-277535-u283k70i	146	14	of	of	IN
cord-277535-u283k70i	146	15	increased	increase	VBN
cord-277535-u283k70i	146	16	bioavalibilty	bioavalibilty	NN
cord-277535-u283k70i	146	17	,	,	,
cord-277535-u283k70i	146	18	the	the	DT
cord-277535-u283k70i	146	19	high	high	JJ
cord-277535-u283k70i	146	20	risk	risk	NN
cord-277535-u283k70i	146	21	of	of	IN
cord-277535-u283k70i	146	22	precipitating	precipitate	VBG
cord-277535-u283k70i	146	23	gastrointestinal	gastrointestinal	JJ
cord-277535-u283k70i	146	24	bleeding	bleeding	NN
cord-277535-u283k70i	146	25	and	and	CC
cord-277535-u283k70i	146	26	renal	renal	JJ
cord-277535-u283k70i	146	27	failure	failure	NN
cord-277535-u283k70i	146	28	.	.	.
cord-277535-u283k70i	147	1	20	20	CD
cord-277535-u283k70i	147	2	Pregabalin	Pregabalin	NNP
cord-277535-u283k70i	147	3	and	and	CC
cord-277535-u283k70i	147	4	gabapentin	gabapentin	NNS
cord-277535-u283k70i	147	5	are	be	VBP
cord-277535-u283k70i	147	6	not	not	RB
cord-277535-u283k70i	147	7	metabolized	metabolize	VBN
cord-277535-u283k70i	147	8	in	in	IN
cord-277535-u283k70i	147	9	the	the	DT
cord-277535-u283k70i	147	10	liver	liver	NN
cord-277535-u283k70i	147	11	and	and	CC
cord-277535-u283k70i	147	12	can	can	MD
cord-277535-u283k70i	147	13	be	be	VB
cord-277535-u283k70i	147	14	considered	consider	VBN
cord-277535-u283k70i	147	15	for	for	IN
cord-277535-u283k70i	147	16	use	use	NN
cord-277535-u283k70i	147	17	.	.	.
cord-277535-u283k70i	148	1	These	these	DT
cord-277535-u283k70i	148	2	drugs	drug	NNS
cord-277535-u283k70i	148	3	are	be	VBP
cord-277535-u283k70i	148	4	renally	renally	RB
cord-277535-u283k70i	148	5	excreted	excrete	VBN
cord-277535-u283k70i	148	6	therefore	therefore	RB
cord-277535-u283k70i	148	7	patients	patient	NNS
cord-277535-u283k70i	148	8	with	with	IN
cord-277535-u283k70i	148	9	hepatorenal	hepatorenal	JJ
cord-277535-u283k70i	148	10	syndrome	syndrome	NNP
cord-277535-u283k70i	148	11	warrant	warrant	VBP
cord-277535-u283k70i	148	12	cautious	cautious	JJ
cord-277535-u283k70i	148	13	adminstration	adminstration	NN
cord-277535-u283k70i	148	14	.	.	.
cord-277535-u283k70i	149	1	18	18	CD
cord-277535-u283k70i	149	2	,	,	,
cord-277535-u283k70i	149	3	20	20	CD
cord-277535-u283k70i	149	4	Gabapentin	Gabapentin	NNP
cord-277535-u283k70i	149	5	is	be	VBZ
cord-277535-u283k70i	149	6	considered	consider	VBN
cord-277535-u283k70i	149	7	as	as	IN
cord-277535-u283k70i	149	8	first	first	JJ
cord-277535-u283k70i	149	9	line	line	NN
cord-277535-u283k70i	149	10	non	non	JJ
cord-277535-u283k70i	149	11	opiod	opiod	NNP
cord-277535-u283k70i	149	12	drug	drug	NN
cord-277535-u283k70i	149	13	for	for	IN
cord-277535-u283k70i	149	14	analgesia	analgesia	NN
cord-277535-u283k70i	149	15	.	.	.
cord-277535-u283k70i	150	1	Among	among	IN
cord-277535-u283k70i	150	2	the	the	DT
cord-277535-u283k70i	150	3	tricyclic	tricyclic	NN
cord-277535-u283k70i	150	4	antidepressants	antidepressant	NNS
cord-277535-u283k70i	150	5	nortryptilline	nortryptilline	NNP
cord-277535-u283k70i	150	6	appear	appear	VBP
cord-277535-u283k70i	150	7	safer	safe	JJR
cord-277535-u283k70i	150	8	than	than	IN
cord-277535-u283k70i	150	9	amitriptyline	amitriptyline	NN
cord-277535-u283k70i	150	10	and	and	CC
cord-277535-u283k70i	150	11	imipramine	imipramine	NN
cord-277535-u283k70i	150	12	.	.	.
cord-277535-u283k70i	151	1	20	20	CD
cord-277535-u283k70i	152	1	An	an	DT
cord-277535-u283k70i	152	2	increased	increased	JJ
cord-277535-u283k70i	152	3	dose	dose	NN
cord-277535-u283k70i	152	4	of	of	IN
cord-277535-u283k70i	152	5	non	non	JJ
cord-277535-u283k70i	152	6	-	-	JJ
cord-277535-u283k70i	152	7	depolarising	depolarising	JJ
cord-277535-u283k70i	152	8	neuromuscular	neuromuscular	JJ
cord-277535-u283k70i	152	9	blockers	blocker	NNS
cord-277535-u283k70i	152	10	(	(	-LRB-
cord-277535-u283k70i	152	11	NMB	NMB	NNP
cord-277535-u283k70i	152	12	)	)	-RRB-
cord-277535-u283k70i	152	13	may	may	MD
cord-277535-u283k70i	152	14	be	be	VB
cord-277535-u283k70i	152	15	required	require	VBN
cord-277535-u283k70i	152	16	in	in	IN
cord-277535-u283k70i	152	17	liver	liver	NN
cord-277535-u283k70i	152	18	disease	disease	NN
cord-277535-u283k70i	152	19	possibly	possibly	RB
cord-277535-u283k70i	152	20	due	due	JJ
cord-277535-u283k70i	152	21	to	to	IN
cord-277535-u283k70i	152	22	altered	alter	VBN
cord-277535-u283k70i	152	23	PHARMACOLOGY	PHARMACOLOGY	NNP
cord-277535-u283k70i	152	24	ANAESTHESIA	ANAESTHESIA	NNP
cord-277535-u283k70i	152	25	AND	and	CC
cord-277535-u283k70i	152	26	INTENSIVE	intensive	JJ
cord-277535-u283k70i	152	27	CARE	care	NN
cord-277535-u283k70i	152	28	MEDICINE	medicine	NN
cord-277535-u283k70i	153	1	xxx	xxx	NNP
cord-277535-u283k70i	153	2	:	:	:
cord-277535-u283k70i	154	1	xxx	xxx	NNP
cord-277535-u283k70i	154	2	protein	protein	NN
cord-277535-u283k70i	154	3	binding	bind	VBG
cord-277535-u283k70i	154	4	and	and	CC
cord-277535-u283k70i	154	5	increased	increased	JJ
cord-277535-u283k70i	154	6	volume	volume	NN
cord-277535-u283k70i	154	7	of	of	IN
cord-277535-u283k70i	154	8	distribution	distribution	NN
cord-277535-u283k70i	154	9	.	.	.
cord-277535-u283k70i	155	1	However	however	RB
cord-277535-u283k70i	155	2	,	,	,
cord-277535-u283k70i	155	3	those	those	DT
cord-277535-u283k70i	155	4	which	which	WDT
cord-277535-u283k70i	155	5	are	be	VBP
cord-277535-u283k70i	155	6	metabolized	metabolize	VBN
cord-277535-u283k70i	155	7	by	by	IN
cord-277535-u283k70i	155	8	the	the	DT
cord-277535-u283k70i	155	9	liver	liver	NN
cord-277535-u283k70i	155	10	have	have	VBP
cord-277535-u283k70i	155	11	a	a	DT
cord-277535-u283k70i	155	12	prolonged	prolonged	JJ
cord-277535-u283k70i	155	13	duration	duration	NN
cord-277535-u283k70i	155	14	of	of	IN
cord-277535-u283k70i	155	15	action	action	NN
cord-277535-u283k70i	155	16	,	,	,
cord-277535-u283k70i	155	17	atracurium	atracurium	NN
cord-277535-u283k70i	155	18	as	as	IN
cord-277535-u283k70i	155	19	metabolized	metabolize	VBN
cord-277535-u283k70i	155	20	in	in	IN
cord-277535-u283k70i	155	21	the	the	DT
cord-277535-u283k70i	155	22	plasma	plasma	NN
cord-277535-u283k70i	155	23	has	have	VBZ
cord-277535-u283k70i	155	24	a	a	DT
cord-277535-u283k70i	155	25	more	more	RBR
cord-277535-u283k70i	155	26	predictable	predictable	JJ
cord-277535-u283k70i	155	27	duration	duration	NN
cord-277535-u283k70i	155	28	of	of	IN
cord-277535-u283k70i	155	29	action	action	NN
cord-277535-u283k70i	155	30	.	.	.
cord-277535-u283k70i	156	1	However	however	RB
cord-277535-u283k70i	156	2	,	,	,
cord-277535-u283k70i	156	3	it	-PRON-	PRP
cord-277535-u283k70i	156	4	is	be	VBZ
cord-277535-u283k70i	156	5	worth	worth	JJ
cord-277535-u283k70i	156	6	noting	note	VBG
cord-277535-u283k70i	156	7	that	that	IN
cord-277535-u283k70i	156	8	in	in	IN
cord-277535-u283k70i	156	9	prolonged	prolonged	JJ
cord-277535-u283k70i	156	10	usage	usage	NN
cord-277535-u283k70i	156	11	concentrations	concentration	NNS
cord-277535-u283k70i	156	12	laudanosine	laudanosine	NN
cord-277535-u283k70i	156	13	from	from	IN
cord-277535-u283k70i	156	14	Hoffmann	Hoffmann	NNP
cord-277535-u283k70i	156	15	degradation	degradation	NN
cord-277535-u283k70i	156	16	may	may	MD
cord-277535-u283k70i	156	17	accumulate	accumulate	VB
cord-277535-u283k70i	156	18	with	with	IN
cord-277535-u283k70i	156	19	the	the	DT
cord-277535-u283k70i	156	20	potential	potential	NN
cord-277535-u283k70i	156	21	to	to	TO
cord-277535-u283k70i	156	22	provoke	provoke	VB
cord-277535-u283k70i	156	23	epileptiform	epileptiform	JJ
cord-277535-u283k70i	156	24	activity	activity	NN
cord-277535-u283k70i	156	25	on	on	IN
cord-277535-u283k70i	156	26	electro	electro	NNP
cord-277535-u283k70i	156	27	encephalography	encephalography	NNP
cord-277535-u283k70i	156	28	(	(	-LRB-
cord-277535-u283k70i	156	29	EEG	EEG	NNP
cord-277535-u283k70i	156	30	)	)	-RRB-
cord-277535-u283k70i	156	31	.	.	.
cord-277535-u283k70i	157	1	13	13	CD
cord-277535-u283k70i	158	1	This	this	DT
cord-277535-u283k70i	158	2	is	be	VBZ
cord-277535-u283k70i	158	3	of	of	IN
cord-277535-u283k70i	158	4	greater	great	JJR
cord-277535-u283k70i	158	5	concern	concern	NN
cord-277535-u283k70i	158	6	if	if	IN
cord-277535-u283k70i	158	7	the	the	DT
cord-277535-u283k70i	158	8	patient	patient	NN
cord-277535-u283k70i	158	9	has	have	VBZ
cord-277535-u283k70i	158	10	concomitant	concomitant	JJ
cord-277535-u283k70i	158	11	renal	renal	JJ
cord-277535-u283k70i	158	12	failure	failure	NN
cord-277535-u283k70i	158	13	or	or	CC
cord-277535-u283k70i	158	14	impaired	impaired	JJ
cord-277535-u283k70i	158	15	blood	blood	NN
cord-277535-u283k70i	158	16	brain	brain	NN
cord-277535-u283k70i	158	17	barrier	barrier	NN
cord-277535-u283k70i	158	18	.	.	.
cord-277535-u283k70i	159	1	The	the	DT
cord-277535-u283k70i	159	2	metabolism	metabolism	NN
cord-277535-u283k70i	159	3	of	of	IN
cord-277535-u283k70i	159	4	succinylcholine	succinylcholine	NN
cord-277535-u283k70i	159	5	may	may	MD
cord-277535-u283k70i	159	6	be	be	VB
cord-277535-u283k70i	159	7	prolonged	prolong	VBN
cord-277535-u283k70i	159	8	due	due	IN
cord-277535-u283k70i	159	9	to	to	IN
cord-277535-u283k70i	159	10	reductions	reduction	NNS
cord-277535-u283k70i	159	11	in	in	IN
cord-277535-u283k70i	159	12	pseudocholinesterase	pseudocholinesterase	NN
cord-277535-u283k70i	159	13	concentrations	concentration	NNS
cord-277535-u283k70i	159	14	,	,	,
cord-277535-u283k70i	159	15	but	but	CC
cord-277535-u283k70i	159	16	clinically	clinically	RB
cord-277535-u283k70i	159	17	this	this	DT
cord-277535-u283k70i	159	18	is	be	VBZ
cord-277535-u283k70i	159	19	of	of	IN
cord-277535-u283k70i	159	20	little	little	JJ
cord-277535-u283k70i	159	21	significance	significance	NN
cord-277535-u283k70i	159	22	.	.	.
cord-277535-u283k70i	160	1	Suggamadex	Suggamadex	NNP
cord-277535-u283k70i	160	2	is	be	VBZ
cord-277535-u283k70i	160	3	a	a	DT
cord-277535-u283k70i	160	4	unique	unique	JJ
cord-277535-u283k70i	160	5	reversal	reversal	NN
cord-277535-u283k70i	160	6	agent	agent	NN
cord-277535-u283k70i	160	7	for	for	IN
cord-277535-u283k70i	160	8	amniosteriodal	amniosteriodal	JJ
cord-277535-u283k70i	160	9	NMB	NMB	NNP
cord-277535-u283k70i	160	10	which	which	WDT
cord-277535-u283k70i	160	11	acts	act	VBZ
cord-277535-u283k70i	160	12	by	by	IN
cord-277535-u283k70i	160	13	chelating	chelate	VBG
cord-277535-u283k70i	160	14	the	the	DT
cord-277535-u283k70i	160	15	NMB	NMB	NNP
cord-277535-u283k70i	160	16	.	.	.
cord-277535-u283k70i	161	1	It	-PRON-	PRP
cord-277535-u283k70i	161	2	is	be	VBZ
cord-277535-u283k70i	161	3	not	not	RB
cord-277535-u283k70i	161	4	metabolized	metabolize	VBN
cord-277535-u283k70i	161	5	and	and	CC
cord-277535-u283k70i	161	6	is	be	VBZ
cord-277535-u283k70i	161	7	excreted	excrete	VBN
cord-277535-u283k70i	161	8	almost	almost	RB
cord-277535-u283k70i	161	9	exclusively	exclusively	RB
cord-277535-u283k70i	161	10	unchanged	unchanged	JJ
cord-277535-u283k70i	161	11	by	by	IN
cord-277535-u283k70i	161	12	the	the	DT
cord-277535-u283k70i	161	13	kidneys	kidney	NNS
cord-277535-u283k70i	161	14	within	within	IN
cord-277535-u283k70i	161	15	24	24	CD
cord-277535-u283k70i	161	16	h.	h.	NNP
cord-277535-u283k70i	161	17	Data	Data	NNP
cord-277535-u283k70i	161	18	regarding	regard	VBG
cord-277535-u283k70i	161	19	use	use	NN
cord-277535-u283k70i	161	20	of	of	IN
cord-277535-u283k70i	161	21	sugammadex	sugammadex	NN
cord-277535-u283k70i	161	22	,	,	,
cord-277535-u283k70i	161	23	in	in	IN
cord-277535-u283k70i	161	24	patients	patient	NNS
cord-277535-u283k70i	161	25	with	with	IN
cord-277535-u283k70i	161	26	liver	liver	NN
cord-277535-u283k70i	161	27	dysfunction	dysfunction	NN
cord-277535-u283k70i	161	28	is	be	VBZ
cord-277535-u283k70i	161	29	limited	limit	VBN
cord-277535-u283k70i	161	30	.	.	.
cord-277535-u283k70i	162	1	However	however	RB
cord-277535-u283k70i	162	2	as	as	IN
cord-277535-u283k70i	162	3	sugammadex	sugammadex	NN
cord-277535-u283k70i	162	4	is	be	VBZ
cord-277535-u283k70i	162	5	almost	almost	RB
cord-277535-u283k70i	162	6	entirely	entirely	RB
cord-277535-u283k70i	162	7	excreted	excreted	JJ
cord-277535-u283k70i	162	8	renally	renally	NN
cord-277535-u283k70i	162	9	,	,	,
cord-277535-u283k70i	162	10	no	no	DT
cord-277535-u283k70i	162	11	dose	dose	JJ
cord-277535-u283k70i	162	12	reduction	reduction	NN
cord-277535-u283k70i	162	13	is	be	VBZ
cord-277535-u283k70i	162	14	required	require	VBN
cord-277535-u283k70i	162	15	in	in	IN
cord-277535-u283k70i	162	16	patients	patient	NNS
cord-277535-u283k70i	162	17	with	with	IN
cord-277535-u283k70i	162	18	mild	mild	JJ
cord-277535-u283k70i	162	19	to	to	IN
cord-277535-u283k70i	162	20	moderate	moderate	JJ
cord-277535-u283k70i	162	21	liver	liver	NN
cord-277535-u283k70i	162	22	dysfunction	dysfunction	NN
cord-277535-u283k70i	162	23	.	.	.
cord-277535-u283k70i	163	1	In	in	IN
cord-277535-u283k70i	163	2	patients	patient	NNS
cord-277535-u283k70i	163	3	undergoing	undergo	VBG
cord-277535-u283k70i	163	4	liver	liver	NN
cord-277535-u283k70i	163	5	transplant	transplant	NN
cord-277535-u283k70i	163	6	sugammadex	sugammadex	NN
cord-277535-u283k70i	163	7	is	be	VBZ
cord-277535-u283k70i	163	8	able	able	JJ
cord-277535-u283k70i	163	9	to	to	TO
cord-277535-u283k70i	163	10	reverse	reverse	VB
cord-277535-u283k70i	163	11	neuromuscular	neuromuscular	JJ
cord-277535-u283k70i	163	12	block	block	NN
cord-277535-u283k70i	163	13	maintained	maintain	VBN
cord-277535-u283k70i	163	14	by	by	IN
cord-277535-u283k70i	163	15	rocuronium	rocuronium	JJ
cord-277535-u283k70i	163	16	continuous	continuous	JJ
cord-277535-u283k70i	163	17	infusion	infusion	NN
cord-277535-u283k70i	163	18	.	.	.
cord-277535-u283k70i	164	1	21	21	CD
cord-277535-u283k70i	165	1	However	however	RB
cord-277535-u283k70i	165	2	it	-PRON-	PRP
cord-277535-u283k70i	165	3	is	be	VBZ
cord-277535-u283k70i	165	4	important	important	JJ
cord-277535-u283k70i	165	5	to	to	TO
cord-277535-u283k70i	165	6	note	note	VB
cord-277535-u283k70i	165	7	that	that	IN
cord-277535-u283k70i	165	8	the	the	DT
cord-277535-u283k70i	165	9	sugammadex	sugammadex	JJ
cord-277535-u283k70i	165	10	recovery	recovery	NN
cord-277535-u283k70i	165	11	time	time	NN
cord-277535-u283k70i	165	12	in	in	IN
cord-277535-u283k70i	165	13	this	this	DT
cord-277535-u283k70i	165	14	population	population	NN
cord-277535-u283k70i	165	15	was	be	VBD
cord-277535-u283k70i	165	16	found	find	VBN
cord-277535-u283k70i	165	17	to	to	TO
cord-277535-u283k70i	165	18	be	be	VB
cord-277535-u283k70i	165	19	considerably	considerably	RB
cord-277535-u283k70i	165	20	longer	long	JJR
cord-277535-u283k70i	165	21	than	than	IN
cord-277535-u283k70i	165	22	in	in	IN
cord-277535-u283k70i	165	23	other	other	JJ
cord-277535-u283k70i	165	24	surgical	surgical	JJ
cord-277535-u283k70i	165	25	settings	setting	NNS
cord-277535-u283k70i	165	26	,	,	,
cord-277535-u283k70i	165	27	and	and	CC
cord-277535-u283k70i	165	28	should	should	MD
cord-277535-u283k70i	165	29	be	be	VB
cord-277535-u283k70i	165	30	considered	consider	VBN
cord-277535-u283k70i	165	31	in	in	IN
cord-277535-u283k70i	165	32	clinical	clinical	JJ
cord-277535-u283k70i	165	33	practice	practice	NN
cord-277535-u283k70i	165	34	.	.	.
cord-277535-u283k70i	166	1	Dexmedetomidine	Dexmedetomidine	NNP
cord-277535-u283k70i	166	2	is	be	VBZ
cord-277535-u283k70i	166	3	a	a	DT
cord-277535-u283k70i	166	4	highly	highly	RB
cord-277535-u283k70i	166	5	selective	selective	JJ
cord-277535-u283k70i	166	6	alpha-2	alpha-2	NN
cord-277535-u283k70i	166	7	receptor	receptor	NN
cord-277535-u283k70i	166	8	agonist	agonist	NN
cord-277535-u283k70i	166	9	,	,	,
cord-277535-u283k70i	166	10	with	with	IN
cord-277535-u283k70i	166	11	analgesic	analgesic	JJ
cord-277535-u283k70i	166	12	,	,	,
cord-277535-u283k70i	166	13	anxiolytic	anxiolytic	JJ
cord-277535-u283k70i	166	14	and	and	CC
cord-277535-u283k70i	166	15	sedative	sedative	JJ
cord-277535-u283k70i	166	16	.	.	.
cord-277535-u283k70i	167	1	It	-PRON-	PRP
cord-277535-u283k70i	167	2	is	be	VBZ
cord-277535-u283k70i	167	3	primarily	primarily	RB
cord-277535-u283k70i	167	4	metabolized	metabolize	VBN
cord-277535-u283k70i	167	5	in	in	IN
cord-277535-u283k70i	167	6	the	the	DT
cord-277535-u283k70i	167	7	liver	liver	NN
cord-277535-u283k70i	167	8	and	and	CC
cord-277535-u283k70i	167	9	may	may	MD
cord-277535-u283k70i	167	10	have	have	VB
cord-277535-u283k70i	167	11	a	a	DT
cord-277535-u283k70i	167	12	prolonged	prolonged	JJ
cord-277535-u283k70i	167	13	half	half	JJ
cord-277535-u283k70i	167	14	-	-	HYPH
cord-277535-u283k70i	167	15	life	life	NN
cord-277535-u283k70i	167	16	in	in	IN
cord-277535-u283k70i	167	17	patients	patient	NNS
cord-277535-u283k70i	167	18	with	with	IN
cord-277535-u283k70i	167	19	liver	liver	NN
cord-277535-u283k70i	167	20	disease	disease	NN
cord-277535-u283k70i	167	21	.	.	.
cord-277535-u283k70i	168	1	Dexmedetomidine	Dexmedetomidine	NNP
cord-277535-u283k70i	168	2	has	have	VBZ
cord-277535-u283k70i	168	3	potential	potential	JJ
cord-277535-u283k70i	168	4	protective	protective	JJ
cord-277535-u283k70i	168	5	effects	effect	NNS
cord-277535-u283k70i	168	6	on	on	IN
cord-277535-u283k70i	168	7	the	the	DT
cord-277535-u283k70i	168	8	liver	liver	NN
cord-277535-u283k70i	168	9	and	and	CC
cord-277535-u283k70i	168	10	intestine	intestine	NN
cord-277535-u283k70i	168	11	during	during	IN
cord-277535-u283k70i	168	12	hepatectomy	hepatectomy	NN
cord-277535-u283k70i	168	13	and	and	CC
cord-277535-u283k70i	168	14	intraoperative	intraoperative	JJ
cord-277535-u283k70i	168	15	use	use	NN
cord-277535-u283k70i	168	16	of	of	IN
cord-277535-u283k70i	168	17	dexmedetomidine	dexmedetomidine	NN
cord-277535-u283k70i	168	18	during	during	IN
cord-277535-u283k70i	168	19	liver	liver	NN
cord-277535-u283k70i	168	20	surgery	surgery	NN
cord-277535-u283k70i	169	1	is	be	VBZ
cord-277535-u283k70i	169	2	subject	subject	JJ
cord-277535-u283k70i	169	3	to	to	IN
cord-277535-u283k70i	169	4	ongoing	ongoing	JJ
cord-277535-u283k70i	169	5	research	research	NN
cord-277535-u283k70i	169	6	.	.	.
cord-277535-u283k70i	170	1	22	22	CD
cord-277535-u283k70i	170	2	Additionally	additionally	RB
cord-277535-u283k70i	170	3	patients	patient	NNS
cord-277535-u283k70i	170	4	with	with	IN
cord-277535-u283k70i	170	5	elevated	elevated	JJ
cord-277535-u283k70i	170	6	bilirubin	bilirubin	NN
cord-277535-u283k70i	170	7	and	and	CC
cord-277535-u283k70i	170	8	bile	bile	NN
cord-277535-u283k70i	170	9	salts	salt	NNS
cord-277535-u283k70i	170	10	secondary	secondary	JJ
cord-277535-u283k70i	170	11	to	to	IN
cord-277535-u283k70i	170	12	jaundice	jaundice	NN
cord-277535-u283k70i	170	13	may	may	MD
cord-277535-u283k70i	170	14	show	show	VB
cord-277535-u283k70i	170	15	bradycardias	bradycardia	NNS
cord-277535-u283k70i	170	16	limiting	limit	VBG
cord-277535-u283k70i	170	17	its	-PRON-	PRP$
cord-277535-u283k70i	170	18	use	use	NN
cord-277535-u283k70i	170	19	.	.	.
cord-277535-u283k70i	171	1	23	23	CD
cord-277535-u283k70i	172	1	Paracetamol	paracetamol	JJ
cord-277535-u283k70i	172	2	overdose	overdose	NN
cord-277535-u283k70i	173	1	Paracetamol	Paracetamol	NNP
cord-277535-u283k70i	173	2	is	be	VBZ
cord-277535-u283k70i	173	3	the	the	DT
cord-277535-u283k70i	173	4	commonest	common	JJS
cord-277535-u283k70i	173	5	drug	drug	NN
cord-277535-u283k70i	173	6	taken	take	VBN
cord-277535-u283k70i	173	7	in	in	IN
cord-277535-u283k70i	173	8	overdose	overdose	NN
cord-277535-u283k70i	173	9	in	in	IN
cord-277535-u283k70i	173	10	the	the	DT
cord-277535-u283k70i	173	11	UK	UK	NNP
cord-277535-u283k70i	173	12	to	to	IN
cord-277535-u283k70i	173	13	date	date	NN
cord-277535-u283k70i	173	14	,	,	,
cord-277535-u283k70i	173	15	it	-PRON-	PRP
cord-277535-u283k70i	173	16	can	can	MD
cord-277535-u283k70i	173	17	result	result	VB
cord-277535-u283k70i	173	18	in	in	IN
cord-277535-u283k70i	173	19	liver	liver	NN
cord-277535-u283k70i	173	20	failure	failure	NN
cord-277535-u283k70i	173	21	and	and	CC
cord-277535-u283k70i	173	22	in	in	IN
cord-277535-u283k70i	173	23	some	some	DT
cord-277535-u283k70i	173	24	cases	case	NNS
cord-277535-u283k70i	173	25	fatal	fatal	JJ
cord-277535-u283k70i	173	26	.	.	.
cord-277535-u283k70i	174	1	24	24	CD
cord-277535-u283k70i	174	2	Hepatocelluar	Hepatocelluar	NNP
cord-277535-u283k70i	174	3	necrosis	necrosis	NN
cord-277535-u283k70i	174	4	can	can	MD
cord-277535-u283k70i	174	5	occur	occur	VB
cord-277535-u283k70i	174	6	if	if	IN
cord-277535-u283k70i	174	7	as	as	RB
cord-277535-u283k70i	174	8	little	little	JJ
cord-277535-u283k70i	174	9	as	as	IN
cord-277535-u283k70i	174	10	7.5	7.5	CD
cord-277535-u283k70i	174	11	g	g	NN
cord-277535-u283k70i	174	12	of	of	IN
cord-277535-u283k70i	174	13	paracetamol	paracetamol	NNP
cord-277535-u283k70i	174	14	is	be	VBZ
cord-277535-u283k70i	174	15	ingested	ingest	VBN
cord-277535-u283k70i	174	16	.	.	.
cord-277535-u283k70i	175	1	Normal	normal	JJ
cord-277535-u283k70i	175	2	pathways	pathway	NNS
cord-277535-u283k70i	175	3	of	of	IN
cord-277535-u283k70i	175	4	metabolism	metabolism	NN
cord-277535-u283k70i	175	5	are	be	VBP
cord-277535-u283k70i	175	6	saturated	saturated	JJ
cord-277535-u283k70i	175	7	and	and	CC
cord-277535-u283k70i	175	8	hepatic	hepatic	JJ
cord-277535-u283k70i	175	9	glutathione	glutathione	NN
cord-277535-u283k70i	175	10	stores	store	NNS
cord-277535-u283k70i	175	11	are	be	VBP
cord-277535-u283k70i	175	12	exhausted	exhausted	JJ
cord-277535-u283k70i	175	13	.	.	.
cord-277535-u283k70i	176	1	Patients	patient	NNS
cord-277535-u283k70i	176	2	are	be	VBP
cord-277535-u283k70i	176	3	often	often	RB
cord-277535-u283k70i	176	4	initially	initially	RB
cord-277535-u283k70i	176	5	asymptomatic	asymptomatic	JJ
cord-277535-u283k70i	176	6	for	for	IN
cord-277535-u283k70i	176	7	the	the	DT
cord-277535-u283k70i	176	8	first	first	JJ
cord-277535-u283k70i	176	9	24	24	CD
cord-277535-u283k70i	176	10	h	h	NN
cord-277535-u283k70i	176	11	before	before	IN
cord-277535-u283k70i	176	12	reporting	report	VBG
cord-277535-u283k70i	176	13	nausea	nausea	NN
cord-277535-u283k70i	176	14	,	,	,
cord-277535-u283k70i	176	15	vomiting	vomiting	NN
cord-277535-u283k70i	176	16	,	,	,
cord-277535-u283k70i	176	17	right	right	JJ
cord-277535-u283k70i	176	18	upper	upper	JJ
cord-277535-u283k70i	176	19	quadrant	quadrant	JJ
cord-277535-u283k70i	176	20	pain	pain	NN
cord-277535-u283k70i	176	21	with	with	IN
cord-277535-u283k70i	176	22	progressive	progressive	JJ
cord-277535-u283k70i	176	23	derangement	derangement	NN
cord-277535-u283k70i	176	24	of	of	IN
cord-277535-u283k70i	176	25	liver	liver	NN
cord-277535-u283k70i	176	26	function	function	NN
cord-277535-u283k70i	176	27	tests	test	NNS
cord-277535-u283k70i	176	28	(	(	-LRB-
cord-277535-u283k70i	176	29	LFTs	LFTs	NNP
cord-277535-u283k70i	176	30	)	)	-RRB-
cord-277535-u283k70i	176	31	after	after	IN
cord-277535-u283k70i	176	32	18	18	CD
cord-277535-u283k70i	176	33	h.	h.	NN
cord-277535-u283k70i	177	1	The	the	DT
cord-277535-u283k70i	177	2	MHRA	MHRA	NNP
cord-277535-u283k70i	177	3	produced	produce	VBD
cord-277535-u283k70i	177	4	new	new	JJ
cord-277535-u283k70i	177	5	guidelines	guideline	NNS
cord-277535-u283k70i	177	6	for	for	IN
cord-277535-u283k70i	177	7	treatment	treatment	NN
cord-277535-u283k70i	177	8	of	of	IN
cord-277535-u283k70i	177	9	paracetamol	paracetamol	JJ
cord-277535-u283k70i	177	10	overdose	overdose	NN
cord-277535-u283k70i	177	11	in	in	IN
cord-277535-u283k70i	177	12	2012	2012	CD
cord-277535-u283k70i	177	13	;	;	:
cord-277535-u283k70i	177	14	the	the	DT
cord-277535-u283k70i	177	15	changes	change	NNS
cord-277535-u283k70i	177	16	included	include	VBD
cord-277535-u283k70i	177	17	an	an	DT
cord-277535-u283k70i	177	18	updated	update	VBN
cord-277535-u283k70i	177	19	nomogram	nomogram	NNP
cord-277535-u283k70i	177	20	and	and	CC
cord-277535-u283k70i	177	21	a	a	DT
cord-277535-u283k70i	177	22	simplified	simplified	JJ
cord-277535-u283k70i	177	23	treatment	treatment	NN
cord-277535-u283k70i	177	24	schedule	schedule	NN
cord-277535-u283k70i	177	25	.	.	.
cord-277535-u283k70i	178	1	25	25	CD
cord-277535-u283k70i	179	1	The	the	DT
cord-277535-u283k70i	179	2	administration	administration	NN
cord-277535-u283k70i	179	3	of	of	IN
cord-277535-u283k70i	179	4	acetylcysteine	acetylcysteine	NNP
cord-277535-u283k70i	179	5	has	have	VBZ
cord-277535-u283k70i	179	6	previously	previously	RB
cord-277535-u283k70i	179	7	been	be	VBN
cord-277535-u283k70i	179	8	based	base	VBN
cord-277535-u283k70i	179	9	on	on	IN
cord-277535-u283k70i	179	10	the	the	DT
cord-277535-u283k70i	179	11	Rumack	Rumack	NNP
cord-277535-u283k70i	179	12	-	-	HYPH
cord-277535-u283k70i	179	13	Matthew	Matthew	NNP
cord-277535-u283k70i	179	14	nomogram	nomogram	NNP
cord-277535-u283k70i	179	15	,	,	,
cord-277535-u283k70i	179	16	which	which	WDT
cord-277535-u283k70i	179	17	divided	divide	VBD
cord-277535-u283k70i	179	18	treatment	treatment	NN
cord-277535-u283k70i	179	19	groups	group	NNS
cord-277535-u283k70i	179	20	into	into	IN
cord-277535-u283k70i	179	21	high	high	JJ
cord-277535-u283k70i	179	22	and	and	CC
cord-277535-u283k70i	179	23	low	low	JJ
cord-277535-u283k70i	179	24	risk	risk	NN
cord-277535-u283k70i	179	25	.	.	.
cord-277535-u283k70i	180	1	The	the	DT
cord-277535-u283k70i	180	2	dose	dose	NN
cord-277535-u283k70i	180	3	was	be	VBD
cord-277535-u283k70i	180	4	then	then	RB
cord-277535-u283k70i	180	5	calculated	calculate	VBN
cord-277535-u283k70i	180	6	on	on	IN
cord-277535-u283k70i	180	7	a	a	DT
cord-277535-u283k70i	180	8	weight	weight	NN
cord-277535-u283k70i	180	9	-	-	HYPH
cord-277535-u283k70i	180	10	based	base	VBN
cord-277535-u283k70i	180	11	table	table	NN
cord-277535-u283k70i	180	12	,	,	,
cord-277535-u283k70i	180	13	which	which	WDT
cord-277535-u283k70i	180	14	increased	increase	VBD
cord-277535-u283k70i	180	15	the	the	DT
cord-277535-u283k70i	180	16	risk	risk	NN
cord-277535-u283k70i	180	17	of	of	IN
cord-277535-u283k70i	180	18	drug	drug	NN
cord-277535-u283k70i	180	19	error	error	NN
cord-277535-u283k70i	180	20	.	.	.
cord-277535-u283k70i	181	1	The	the	DT
cord-277535-u283k70i	181	2	updated	update	VBN
cord-277535-u283k70i	181	3	nomogram	nomogram	NNP
cord-277535-u283k70i	181	4	has	have	VBZ
cord-277535-u283k70i	181	5	a	a	DT
cord-277535-u283k70i	181	6	single	single	JJ
cord-277535-u283k70i	181	7	treatment	treatment	NN
cord-277535-u283k70i	181	8	line	line	NN
cord-277535-u283k70i	181	9	(	(	-LRB-
cord-277535-u283k70i	181	10	Figure	figure	NN
cord-277535-u283k70i	181	11	1	1	CD
cord-277535-u283k70i	181	12	)	)	-RRB-
cord-277535-u283k70i	181	13	25	25	CD
cord-277535-u283k70i	181	14	;	;	:
cord-277535-u283k70i	181	15	thereby	thereby	RB
cord-277535-u283k70i	181	16	eliminating	eliminate	VBG
cord-277535-u283k70i	181	17	the	the	DT
cord-277535-u283k70i	181	18	need	need	NN
cord-277535-u283k70i	181	19	for	for	IN
cord-277535-u283k70i	181	20	assessing	assess	VBG
cord-277535-u283k70i	181	21	whether	whether	IN
cord-277535-u283k70i	181	22	the	the	DT
cord-277535-u283k70i	181	23	patient	patient	NN
cord-277535-u283k70i	181	24	falls	fall	VBZ
cord-277535-u283k70i	181	25	into	into	IN
cord-277535-u283k70i	181	26	the	the	DT
cord-277535-u283k70i	181	27	high	high	JJ
cord-277535-u283k70i	181	28	-	-	HYPH
cord-277535-u283k70i	181	29	risk	risk	NN
cord-277535-u283k70i	181	30	category	category	NN
cord-277535-u283k70i	181	31	.	.	.
cord-277535-u283k70i	182	1	It	-PRON-	PRP
cord-277535-u283k70i	182	2	also	also	RB
cord-277535-u283k70i	182	3	advises	advise	VBZ
cord-277535-u283k70i	182	4	that	that	IN
cord-277535-u283k70i	182	5	in	in	IN
cord-277535-u283k70i	182	6	cases	case	NNS
cord-277535-u283k70i	182	7	of	of	IN
cord-277535-u283k70i	182	8	staggered	stagger	VBN
cord-277535-u283k70i	182	9	overdoses	overdose	NNS
cord-277535-u283k70i	182	10	there	there	EX
cord-277535-u283k70i	182	11	should	should	MD
cord-277535-u283k70i	182	12	be	be	VB
cord-277535-u283k70i	182	13	no	no	DT
cord-277535-u283k70i	182	14	delay	delay	NN
cord-277535-u283k70i	182	15	in	in	IN
cord-277535-u283k70i	182	16	the	the	DT
cord-277535-u283k70i	182	17	administration	administration	NN
cord-277535-u283k70i	182	18	of	of	IN
cord-277535-u283k70i	182	19	acetylcysteine	acetylcysteine	NNP
cord-277535-u283k70i	182	20	.	.	.
cord-277535-u283k70i	183	1	Another	another	DT
cord-277535-u283k70i	183	2	cause	cause	NN
cord-277535-u283k70i	183	3	for	for	IN
cord-277535-u283k70i	183	4	concern	concern	NN
cord-277535-u283k70i	183	5	was	be	VBD
cord-277535-u283k70i	183	6	the	the	DT
cord-277535-u283k70i	183	7	adverse	adverse	JJ
cord-277535-u283k70i	183	8	events	event	NNS
cord-277535-u283k70i	183	9	that	that	WDT
cord-277535-u283k70i	183	10	had	have	VBD
cord-277535-u283k70i	183	11	been	be	VBN
cord-277535-u283k70i	183	12	reported	report	VBN
cord-277535-u283k70i	183	13	following	follow	VBG
cord-277535-u283k70i	183	14	the	the	DT
cord-277535-u283k70i	183	15	bolus	bolus	NN
cord-277535-u283k70i	183	16	dose	dose	NN
cord-277535-u283k70i	183	17	of	of	IN
cord-277535-u283k70i	183	18	acetylcysteine	acetylcysteine	NN
cord-277535-u283k70i	183	19	,	,	,
cord-277535-u283k70i	183	20	this	this	DT
cord-277535-u283k70i	183	21	has	have	VBZ
cord-277535-u283k70i	183	22	been	be	VBN
cord-277535-u283k70i	183	23	addressed	address	VBN
cord-277535-u283k70i	183	24	by	by	IN
cord-277535-u283k70i	183	25	increasing	increase	VBG
cord-277535-u283k70i	183	26	the	the	DT
cord-277535-u283k70i	183	27	duration	duration	NN
cord-277535-u283k70i	183	28	over	over	IN
cord-277535-u283k70i	183	29	which	which	WDT
cord-277535-u283k70i	183	30	it	-PRON-	PRP
cord-277535-u283k70i	183	31	is	be	VBZ
cord-277535-u283k70i	183	32	infused	infuse	VBN
cord-277535-u283k70i	183	33	,	,	,
cord-277535-u283k70i	183	34	from	from	IN
cord-277535-u283k70i	183	35	15	15	CD
cord-277535-u283k70i	183	36	min	min	NN
cord-277535-u283k70i	183	37	to	to	IN
cord-277535-u283k70i	183	38	60	60	CD
cord-277535-u283k70i	183	39	min	min	NN
cord-277535-u283k70i	183	40	.	.	.
cord-277535-u283k70i	184	1	Acetylcysteine	Acetylcysteine	NNP
cord-277535-u283k70i	184	2	should	should	MD
cord-277535-u283k70i	184	3	be	be	VB
cord-277535-u283k70i	184	4	administered	administer	VBN
cord-277535-u283k70i	184	5	when	when	WRB
cord-277535-u283k70i	184	6	the	the	DT
cord-277535-u283k70i	184	7	plasma	plasma	NN
cord-277535-u283k70i	184	8	paracetamol	paracetamol	JJ
cord-277535-u283k70i	184	9	level	level	NN
cord-277535-u283k70i	184	10	is	be	VBZ
cord-277535-u283k70i	184	11	on	on	IN
cord-277535-u283k70i	184	12	or	or	CC
cord-277535-u283k70i	184	13	above	above	IN
cord-277535-u283k70i	184	14	a	a	DT
cord-277535-u283k70i	184	15	single	single	JJ
cord-277535-u283k70i	184	16	treatment	treatment	NN
cord-277535-u283k70i	184	17	line	line	NN
cord-277535-u283k70i	184	18	joining	join	VBG
cord-277535-u283k70i	184	19	points	point	NNS
cord-277535-u283k70i	184	20	of	of	IN
cord-277535-u283k70i	184	21	100mg	100mg	NNP
cord-277535-u283k70i	184	22	/	/	SYM
cord-277535-u283k70i	184	23	L	L	NNP
cord-277535-u283k70i	184	24	at	at	IN
cord-277535-u283k70i	184	25	4	4	CD
cord-277535-u283k70i	184	26	h	h	NN
cord-277535-u283k70i	184	27	and	and	CC
cord-277535-u283k70i	184	28	15mg	15mg	NNP
cord-277535-u283k70i	184	29	/	/	SYM
cord-277535-u283k70i	184	30	L	l	NN
cord-277535-u283k70i	184	31	at	at	IN
cord-277535-u283k70i	184	32	15	15	CD
cord-277535-u283k70i	184	33	h	h	NN
cord-277535-u283k70i	184	34	after	after	IN
cord-277535-u283k70i	184	35	ingestion	ingestion	NN
cord-277535-u283k70i	184	36	.	.	.
cord-277535-u283k70i	185	1	A	a	DT
cord-277535-u283k70i	185	2	baseline	baseline	JJ
cord-277535-u283k70i	185	3	full	full	JJ
cord-277535-u283k70i	185	4	blood	blood	NN
cord-277535-u283k70i	185	5	count	count	NN
cord-277535-u283k70i	185	6	(	(	-LRB-
cord-277535-u283k70i	185	7	FBC	FBC	NNP
cord-277535-u283k70i	185	8	)	)	-RRB-
cord-277535-u283k70i	185	9	,	,	,
cord-277535-u283k70i	185	10	urea	urea	NN
cord-277535-u283k70i	185	11	and	and	CC
cord-277535-u283k70i	185	12	electrolytes	electrolyte	NNS
cord-277535-u283k70i	185	13	(	(	-LRB-
cord-277535-u283k70i	185	14	U&Es	U&Es	NNP
cord-277535-u283k70i	185	15	)	)	-RRB-
cord-277535-u283k70i	185	16	,	,	,
cord-277535-u283k70i	185	17	LFTs	lft	NNS
cord-277535-u283k70i	185	18	and	and	CC
cord-277535-u283k70i	185	19	coagulation	coagulation	NN
cord-277535-u283k70i	185	20	screen	screen	NN
cord-277535-u283k70i	185	21	along	along	IN
cord-277535-u283k70i	185	22	with	with	IN
cord-277535-u283k70i	185	23	an	an	DT
cord-277535-u283k70i	185	24	arterial	arterial	JJ
cord-277535-u283k70i	185	25	blood	blood	NN
cord-277535-u283k70i	185	26	gas	gas	NN
cord-277535-u283k70i	185	27	sample	sample	NN
cord-277535-u283k70i	185	28	should	should	MD
cord-277535-u283k70i	185	29	also	also	RB
cord-277535-u283k70i	185	30	be	be	VB
cord-277535-u283k70i	185	31	done	do	VBN
cord-277535-u283k70i	185	32	at	at	IN
cord-277535-u283k70i	185	33	the	the	DT
cord-277535-u283k70i	185	34	earliest	early	JJS
cord-277535-u283k70i	185	35	opportunity	opportunity	NN
cord-277535-u283k70i	185	36	.	.	.
cord-277535-u283k70i	186	1	Intravenous	intravenous	JJ
cord-277535-u283k70i	186	2	preparations	preparation	NNS
cord-277535-u283k70i	186	3	of	of	IN
cord-277535-u283k70i	186	4	paracetamol	paracetamol	NNP
cord-277535-u283k70i	186	5	were	be	VBD
cord-277535-u283k70i	186	6	licensed	license	VBN
cord-277535-u283k70i	186	7	in	in	IN
cord-277535-u283k70i	186	8	the	the	DT
cord-277535-u283k70i	186	9	UK	UK	NNP
cord-277535-u283k70i	186	10	in	in	IN
cord-277535-u283k70i	186	11	2004	2004	CD
cord-277535-u283k70i	186	12	and	and	CC
cord-277535-u283k70i	186	13	it	-PRON-	PRP
cord-277535-u283k70i	186	14	is	be	VBZ
cord-277535-u283k70i	186	15	routinely	routinely	RB
cord-277535-u283k70i	186	16	used	use	VBN
cord-277535-u283k70i	186	17	in	in	IN
cord-277535-u283k70i	186	18	anaesthetic	anaesthetic	JJ
cord-277535-u283k70i	186	19	practice	practice	NN
cord-277535-u283k70i	186	20	.	.	.
cord-277535-u283k70i	187	1	However	however	RB
cord-277535-u283k70i	187	2	,	,	,
cord-277535-u283k70i	187	3	there	there	EX
cord-277535-u283k70i	187	4	have	have	VBP
cord-277535-u283k70i	187	5	been	be	VBN
cord-277535-u283k70i	187	6	some	some	DT
cord-277535-u283k70i	187	7	concerns	concern	NNS
cord-277535-u283k70i	187	8	regarding	regard	VBG
cord-277535-u283k70i	187	9	the	the	DT
cord-277535-u283k70i	187	10	dosage	dosage	NN
cord-277535-u283k70i	187	11	and	and	CC
cord-277535-u283k70i	187	12	administration	administration	NN
cord-277535-u283k70i	187	13	;	;	:
cord-277535-u283k70i	187	14	especially	especially	RB
cord-277535-u283k70i	187	15	in	in	IN
cord-277535-u283k70i	187	16	adults	adult	NNS
cord-277535-u283k70i	187	17	and	and	CC
cord-277535-u283k70i	187	18	children	child	NNS
cord-277535-u283k70i	187	19	under	under	IN
cord-277535-u283k70i	187	20	50	50	CD
cord-277535-u283k70i	187	21	kg	kg	NNS
cord-277535-u283k70i	187	22	,	,	,
cord-277535-u283k70i	187	23	patients	patient	NNS
cord-277535-u283k70i	187	24	with	with	IN
cord-277535-u283k70i	187	25	pre	pre	JJ
cord-277535-u283k70i	187	26	-	-	JJ
cord-277535-u283k70i	187	27	existing	existing	JJ
cord-277535-u283k70i	187	28	hepatic	hepatic	JJ
cord-277535-u283k70i	187	29	dysfunction	dysfunction	NN
cord-277535-u283k70i	187	30	and	and	CC
cord-277535-u283k70i	187	31	the	the	DT
cord-277535-u283k70i	187	32	elderly	elderly	JJ
cord-277535-u283k70i	187	33	.	.	.
cord-277535-u283k70i	188	1	Children	child	NNS
cord-277535-u283k70i	188	2	and	and	CC
cord-277535-u283k70i	188	3	infants	infant	NNS
cord-277535-u283k70i	188	4	weighing	weigh	VBG
cord-277535-u283k70i	188	5	less	less	JJR
cord-277535-u283k70i	188	6	than	than	IN
cord-277535-u283k70i	188	7	10	10	CD
cord-277535-u283k70i	188	8	kg	kg	NNS
cord-277535-u283k70i	188	9	should	should	MD
cord-277535-u283k70i	188	10	receive	receive	VB
cord-277535-u283k70i	188	11	the	the	DT
cord-277535-u283k70i	188	12	reduced	reduced	JJ
cord-277535-u283k70i	188	13	dose	dose	NN
cord-277535-u283k70i	188	14	of	of	IN
cord-277535-u283k70i	188	15	7.5mg	7.5mg	CD
cord-277535-u283k70i	188	16	/	/	SYM
cord-277535-u283k70i	188	17	kg	kg	NNS
cord-277535-u283k70i	188	18	not	not	RB
cord-277535-u283k70i	188	19	exceeding	exceed	VBG
cord-277535-u283k70i	188	20	the	the	DT
cord-277535-u283k70i	188	21	daily	daily	JJ
cord-277535-u283k70i	188	22	dose	dose	NN
cord-277535-u283k70i	188	23	of	of	IN
cord-277535-u283k70i	188	24	30mg/	30mg/	CD
cord-277535-u283k70i	188	25	kg	kg	NNS
cord-277535-u283k70i	188	26	,	,	,
cord-277535-u283k70i	188	27	whilst	whilst	IN
cord-277535-u283k70i	188	28	those	those	DT
cord-277535-u283k70i	188	29	>	>	XX
cord-277535-u283k70i	188	30	10	10	CD
cord-277535-u283k70i	188	31	kg	kg	NNS
cord-277535-u283k70i	188	32	can	can	MD
cord-277535-u283k70i	188	33	be	be	VB
cord-277535-u283k70i	188	34	prescribed	prescribe	VBN
cord-277535-u283k70i	188	35	up	up	RP
cord-277535-u283k70i	188	36	to	to	IN
cord-277535-u283k70i	188	37	15mg	15mg	NN
cord-277535-u283k70i	188	38	/	/	SYM
cord-277535-u283k70i	188	39	kg	kg	NNS
cord-277535-u283k70i	188	40	not	not	RB
cord-277535-u283k70i	188	41	exceeding	exceed	VBG
cord-277535-u283k70i	188	42	the	the	DT
cord-277535-u283k70i	188	43	daily	daily	JJ
cord-277535-u283k70i	188	44	dose	dose	NN
cord-277535-u283k70i	188	45	of	of	IN
cord-277535-u283k70i	188	46	60mg	60mg	NN
cord-277535-u283k70i	188	47	/	/	SYM
cord-277535-u283k70i	188	48	kg	kg	NNS
cord-277535-u283k70i	188	49	.	.	.
cord-277535-u283k70i	189	1	Both	both	DT
cord-277535-u283k70i	189	2	the	the	DT
cord-277535-u283k70i	189	3	MHRA	MHRA	NNP
cord-277535-u283k70i	189	4	and	and	CC
cord-277535-u283k70i	189	5	the	the	DT
cord-277535-u283k70i	189	6	NPSA	NPSA	NNP
cord-277535-u283k70i	189	7	have	have	VBP
cord-277535-u283k70i	189	8	issued	issue	VBN
cord-277535-u283k70i	189	9	alerts	alert	NNS
cord-277535-u283k70i	189	10	,	,	,
cord-277535-u283k70i	189	11	regarding	regard	VBG
cord-277535-u283k70i	189	12	the	the	DT
cord-277535-u283k70i	189	13	correct	correct	JJ
cord-277535-u283k70i	189	14	dose	dose	NN
cord-277535-u283k70i	189	15	prescription	prescription	NN
cord-277535-u283k70i	189	16	as	as	IN
cord-277535-u283k70i	189	17	there	there	EX
cord-277535-u283k70i	189	18	have	have	VBP
cord-277535-u283k70i	189	19	been	be	VBN
cord-277535-u283k70i	189	20	reported	report	VBN
cord-277535-u283k70i	189	21	cases	case	NNS
cord-277535-u283k70i	189	22	of	of	IN
cord-277535-u283k70i	189	23	accidental	accidental	JJ
cord-277535-u283k70i	189	24	overdose	overdose	NN
cord-277535-u283k70i	189	25	due	due	IN
cord-277535-u283k70i	189	26	to	to	IN
cord-277535-u283k70i	189	27	ml	ml	NNS
cord-277535-u283k70i	189	28	to	to	IN
cord-277535-u283k70i	189	29	mg	mg	NNP
cord-277535-u283k70i	189	30	conversion	conversion	NN
cord-277535-u283k70i	189	31	and	and	CC
cord-277535-u283k70i	189	32	the	the	DT
cord-277535-u283k70i	189	33	administration	administration	NN
cord-277535-u283k70i	189	34	of	of	IN
cord-277535-u283k70i	189	35	1	1	CD
cord-277535-u283k70i	189	36	g	g	NN
cord-277535-u283k70i	189	37	in	in	IN
cord-277535-u283k70i	189	38	adults	adult	NNS
cord-277535-u283k70i	189	39	weighing	weigh	VBG
cord-277535-u283k70i	189	40	less	less	JJR
cord-277535-u283k70i	189	41	than	than	IN
cord-277535-u283k70i	189	42	50	50	CD
cord-277535-u283k70i	189	43	kg	kg	NNS
cord-277535-u283k70i	189	44	.	.	.
cord-277535-u283k70i	190	1	The	the	DT
cord-277535-u283k70i	190	2	key	key	JJ
cord-277535-u283k70i	190	3	issue	issue	NN
cord-277535-u283k70i	190	4	is	be	VBZ
cord-277535-u283k70i	190	5	that	that	IN
cord-277535-u283k70i	190	6	with	with	IN
cord-277535-u283k70i	190	7	intravenous	intravenous	JJ
cord-277535-u283k70i	190	8	paracetamol	paracetamol	JJ
cord-277535-u283k70i	190	9	plasma	plasma	NN
cord-277535-u283k70i	190	10	levels	level	NNS
cord-277535-u283k70i	190	11	will	will	MD
cord-277535-u283k70i	190	12	peak	peak	VB
cord-277535-u283k70i	190	13	immediately	immediately	RB
cord-277535-u283k70i	190	14	after	after	IN
cord-277535-u283k70i	190	15	administration	administration	NN
cord-277535-u283k70i	190	16	.	.	.
cord-277535-u283k70i	191	1	The	the	DT
cord-277535-u283k70i	191	2	traditional	traditional	JJ
cord-277535-u283k70i	191	3	nomograms	nomogram	NNS
cord-277535-u283k70i	191	4	used	use	VBN
cord-277535-u283k70i	191	5	to	to	TO
cord-277535-u283k70i	191	6	predict	predict	VB
cord-277535-u283k70i	191	7	plasma	plasma	NN
cord-277535-u283k70i	191	8	levels	level	NNS
cord-277535-u283k70i	191	9	after	after	IN
cord-277535-u283k70i	191	10	overdose	overdose	NN
cord-277535-u283k70i	191	11	refer	refer	NN
cord-277535-u283k70i	191	12	to	to	IN
cord-277535-u283k70i	191	13	oral	oral	JJ
cord-277535-u283k70i	191	14	ingestion	ingestion	NN
cord-277535-u283k70i	191	15	where	where	WRB
cord-277535-u283k70i	191	16	the	the	DT
cord-277535-u283k70i	191	17	levels	level	NNS
cord-277535-u283k70i	191	18	peak	peak	VBP
cord-277535-u283k70i	191	19	some	some	DT
cord-277535-u283k70i	191	20	hours	hour	NNS
cord-277535-u283k70i	191	21	after	after	RB
cord-277535-u283k70i	191	22	.	.	.
cord-277535-u283k70i	192	1	Indicators	indicator	NNS
cord-277535-u283k70i	192	2	of	of	IN
cord-277535-u283k70i	192	3	severe	severe	JJ
cord-277535-u283k70i	192	4	paracetamol	paracetamol	JJ
cord-277535-u283k70i	192	5	poisoning	poisoning	NN
cord-277535-u283k70i	192	6	which	which	WDT
cord-277535-u283k70i	192	7	is	be	VBZ
cord-277535-u283k70i	192	8	likely	likely	JJ
cord-277535-u283k70i	192	9	to	to	TO
cord-277535-u283k70i	192	10	require	require	VB
cord-277535-u283k70i	192	11	referral	referral	NN
cord-277535-u283k70i	192	12	to	to	IN
cord-277535-u283k70i	192	13	a	a	DT
cord-277535-u283k70i	192	14	specialist	specialist	JJ
cord-277535-u283k70i	192	15	liver	liver	NN
cord-277535-u283k70i	192	16	centre	centre	NN
cord-277535-u283k70i	192	17	include	include	VBP
cord-277535-u283k70i	192	18	:	:	:
cord-277535-u283k70i	192	19	INR	INR	NNP
cord-277535-u283k70i	192	20	of	of	IN
cord-277535-u283k70i	192	21	>	>	$
cord-277535-u283k70i	192	22	2.0	2.0	CD
cord-277535-u283k70i	192	23	at	at	IN
cord-277535-u283k70i	192	24	24	24	CD
cord-277535-u283k70i	192	25	h	h	NN
cord-277535-u283k70i	192	26	,	,	,
cord-277535-u283k70i	192	27	>	>	XX
cord-277535-u283k70i	192	28	4	4	CD
cord-277535-u283k70i	192	29	at	at	IN
cord-277535-u283k70i	192	30	48	48	CD
cord-277535-u283k70i	192	31	h	h	NN
cord-277535-u283k70i	192	32	or	or	CC
cord-277535-u283k70i	192	33	>	>	XX
cord-277535-u283k70i	192	34	6	6	CD
cord-277535-u283k70i	192	35	at	at	IN
cord-277535-u283k70i	192	36	72	72	CD
cord-277535-u283k70i	192	37	hours	hour	NNS
cord-277535-u283k70i	192	38	;	;	,
cord-277535-u283k70i	192	39	renal	renal	JJ
cord-277535-u283k70i	192	40	impairment	impairment	NN
cord-277535-u283k70i	192	41	(	(	-LRB-
cord-277535-u283k70i	192	42	creatinine	creatinine	NN
cord-277535-u283k70i	192	43	>	>	XX
cord-277535-u283k70i	192	44	200	200	CD
cord-277535-u283k70i	192	45	micromol	micromol	JJ
cord-277535-u283k70i	192	46	/	/	SYM
cord-277535-u283k70i	192	47	l	l	NN
cord-277535-u283k70i	192	48	)	)	-RRB-
cord-277535-u283k70i	192	49	;	;	:
cord-277535-u283k70i	192	50	hypoglycaemia	hypoglycaemia	NN
cord-277535-u283k70i	192	51	;	;	:
cord-277535-u283k70i	192	52	metabolic	metabolic	JJ
cord-277535-u283k70i	192	53	acidosis	acidosis	NN
cord-277535-u283k70i	192	54	despite	despite	IN
cord-277535-u283k70i	192	55	rehydration	rehydration	NN
cord-277535-u283k70i	192	56	;	;	:
cord-277535-u283k70i	192	57	hypotension	hypotension	NN
cord-277535-u283k70i	192	58	despite	despite	IN
cord-277535-u283k70i	192	59	resuscitation	resuscitation	NN
cord-277535-u283k70i	192	60	or	or	CC
cord-277535-u283k70i	192	61	encephalopathy	encephalopathy	NN
cord-277535-u283k70i	192	62	.	.	.
cord-277535-u283k70i	193	1	26	26	CD
cord-277535-u283k70i	194	1	The	the	DT
cord-277535-u283k70i	194	2	only	only	JJ
cord-277535-u283k70i	194	3	other	other	JJ
cord-277535-u283k70i	194	4	treatment	treatment	NN
cord-277535-u283k70i	194	5	in	in	IN
cord-277535-u283k70i	194	6	fulminant	fulminant	JJ
cord-277535-u283k70i	194	7	liver	liver	NN
cord-277535-u283k70i	194	8	failure	failure	NN
cord-277535-u283k70i	194	9	is	be	VBZ
cord-277535-u283k70i	194	10	transplantation	transplantation	NN
cord-277535-u283k70i	194	11	.	.	.
cord-277535-u283k70i	195	1	Paracetamol	paracetamol	JJ
cord-277535-u283k70i	195	2	as	as	IN
cord-277535-u283k70i	195	3	analgesic	analgesic	JJ
cord-277535-u283k70i	195	4	in	in	IN
cord-277535-u283k70i	195	5	chronic	chronic	JJ
cord-277535-u283k70i	195	6	liver	liver	NN
cord-277535-u283k70i	195	7	disease	disease	NN
cord-277535-u283k70i	196	1	Given	give	VBN
cord-277535-u283k70i	196	2	the	the	DT
cord-277535-u283k70i	196	3	potential	potential	NN
cord-277535-u283k70i	196	4	of	of	IN
cord-277535-u283k70i	196	5	paracetamol	paracetamol	NN
cord-277535-u283k70i	196	6	to	to	TO
cord-277535-u283k70i	196	7	cause	cause	VB
cord-277535-u283k70i	196	8	liver	liver	NN
cord-277535-u283k70i	196	9	injury	injury	NN
cord-277535-u283k70i	196	10	,	,	,
cord-277535-u283k70i	196	11	there	there	EX
cord-277535-u283k70i	196	12	is	be	VBZ
cord-277535-u283k70i	196	13	a	a	DT
cord-277535-u283k70i	196	14	common	common	JJ
cord-277535-u283k70i	196	15	misconception	misconception	NN
cord-277535-u283k70i	196	16	that	that	IN
cord-277535-u283k70i	196	17	these	these	DT
cord-277535-u283k70i	196	18	patients	patient	NNS
cord-277535-u283k70i	196	19	should	should	MD
cord-277535-u283k70i	196	20	never	never	RB
cord-277535-u283k70i	196	21	take	take	VB
cord-277535-u283k70i	196	22	paracetamol	paracetamol	NN
cord-277535-u283k70i	196	23	.	.	.
cord-277535-u283k70i	197	1	However	however	RB
cord-277535-u283k70i	197	2	,	,	,
cord-277535-u283k70i	197	3	various	various	JJ
cord-277535-u283k70i	197	4	studies	study	NNS
cord-277535-u283k70i	197	5	have	have	VBP
cord-277535-u283k70i	197	6	shown	show	VBN
cord-277535-u283k70i	197	7	that	that	IN
cord-277535-u283k70i	197	8	if	if	IN
cord-277535-u283k70i	197	9	taken	take	VBN
cord-277535-u283k70i	197	10	in	in	IN
cord-277535-u283k70i	197	11	appropriate	appropriate	JJ
cord-277535-u283k70i	197	12	doses	dose	NNS
cord-277535-u283k70i	197	13	,	,	,
cord-277535-u283k70i	197	14	paracetamol	paracetamol	NN
cord-277535-u283k70i	197	15	is	be	VBZ
cord-277535-u283k70i	197	16	one	one	CD
cord-277535-u283k70i	197	17	of	of	IN
cord-277535-u283k70i	197	18	the	the	DT
cord-277535-u283k70i	197	19	safest	safe	JJS
cord-277535-u283k70i	197	20	analgesics	analgesic	NNS
cord-277535-u283k70i	197	21	for	for	IN
cord-277535-u283k70i	197	22	patients	patient	NNS
cord-277535-u283k70i	197	23	with	with	IN
cord-277535-u283k70i	197	24	cirrhosis	cirrhosis	NN
cord-277535-u283k70i	197	25	.	.	.
cord-277535-u283k70i	198	1	Limiting	limit	VBG
cord-277535-u283k70i	198	2	the	the	DT
cord-277535-u283k70i	198	3	total	total	JJ
cord-277535-u283k70i	198	4	daily	daily	JJ
cord-277535-u283k70i	198	5	dosage	dosage	NN
cord-277535-u283k70i	198	6	to	to	IN
cord-277535-u283k70i	198	7	2e3	2e3	NNP
cord-277535-u283k70i	198	8	g	g	NN
cord-277535-u283k70i	198	9	/	/	SYM
cord-277535-u283k70i	198	10	day	day	NN
cord-277535-u283k70i	198	11	with	with	IN
cord-277535-u283k70i	198	12	thrice	thrice	RB
cord-277535-u283k70i	198	13	daily	daily	JJ
cord-277535-u283k70i	198	14	dosing	dosing	NN
cord-277535-u283k70i	198	15	is	be	VBZ
cord-277535-u283k70i	198	16	generally	generally	RB
cord-277535-u283k70i	198	17	recommended	recommend	VBN
cord-277535-u283k70i	198	18	.	.	.
cord-277535-u283k70i	199	1	27	27	CD
cord-277535-u283k70i	199	2	Patients	patient	NNS
cord-277535-u283k70i	199	3	should	should	MD
cord-277535-u283k70i	199	4	be	be	VB
cord-277535-u283k70i	199	5	educated	educate	VBN
cord-277535-u283k70i	199	6	about	about	IN
cord-277535-u283k70i	199	7	over	over	IN
cord-277535-u283k70i	199	8	-	-	HYPH
cord-277535-u283k70i	199	9	the	the	DT
cord-277535-u283k70i	199	10	-	-	HYPH
cord-277535-u283k70i	199	11	counter	counter	NN
cord-277535-u283k70i	199	12	and	and	CC
cord-277535-u283k70i	199	13	prescription	prescription	NN
cord-277535-u283k70i	199	14	medications	medication	NNS
cord-277535-u283k70i	199	15	that	that	WDT
cord-277535-u283k70i	199	16	may	may	MD
cord-277535-u283k70i	199	17	also	also	RB
cord-277535-u283k70i	199	18	contain	contain	VB
cord-277535-u283k70i	199	19	acetaminophen	acetaminophen	NN
cord-277535-u283k70i	199	20	to	to	TO
cord-277535-u283k70i	199	21	avoid	avoid	VB
cord-277535-u283k70i	199	22	overdose	overdose	NN
cord-277535-u283k70i	199	23	.	.	.
cord-277535-u283k70i	200	1	Remdesvir	Remdesvir	NNP
cord-277535-u283k70i	200	2	:	:	:
cord-277535-u283k70i	201	1	elevated	elevated	JJ
cord-277535-u283k70i	201	2	liver	liver	NN
cord-277535-u283k70i	201	3	enzymes	enzyme	NNS
cord-277535-u283k70i	201	4	are	be	VBP
cord-277535-u283k70i	201	5	commonly	commonly	RB
cord-277535-u283k70i	201	6	observed	observe	VBN
cord-277535-u283k70i	201	7	in	in	IN
cord-277535-u283k70i	201	8	clinical	clinical	JJ
cord-277535-u283k70i	201	9	trials	trial	NNS
cord-277535-u283k70i	201	10	of	of	IN
cord-277535-u283k70i	201	11	patients	patient	NNS
cord-277535-u283k70i	201	12	with	with	IN
cord-277535-u283k70i	201	13	remedevir	remedevir	NNS
cord-277535-u283k70i	201	14	.	.	.
cord-277535-u283k70i	202	1	28	28	CD
cord-277535-u283k70i	203	1	The	the	DT
cord-277535-u283k70i	203	2	elevated	elevated	JJ
cord-277535-u283k70i	203	3	values	value	NNS
cord-277535-u283k70i	203	4	rarely	rarely	RB
cord-277535-u283k70i	203	5	warrant	warrant	VBP
cord-277535-u283k70i	203	6	treatment	treatment	NN
cord-277535-u283k70i	203	7	discontinuation	discontinuation	NN
cord-277535-u283k70i	203	8	.	.	.
cord-277535-u283k70i	204	1	Current	current	JJ
cord-277535-u283k70i	204	2	recommendations	recommendation	NNS
cord-277535-u283k70i	204	3	suggest	suggest	VBP
cord-277535-u283k70i	204	4	that	that	IN
cord-277535-u283k70i	204	5	if	if	IN
cord-277535-u283k70i	204	6	the	the	DT
cord-277535-u283k70i	204	7	enzymes	enzyme	NNS
cord-277535-u283k70i	204	8	are	be	VBP
cord-277535-u283k70i	204	9	elevated	elevate	VBN
cord-277535-u283k70i	204	10	to	to	IN
cord-277535-u283k70i	204	11	5	5	CD
cord-277535-u283k70i	204	12	times	time	NNS
cord-277535-u283k70i	204	13	or	or	CC
cord-277535-u283k70i	204	14	more	more	RBR
cord-277535-u283k70i	204	15	above	above	IN
cord-277535-u283k70i	204	16	baseline	baseline	NN
cord-277535-u283k70i	204	17	,	,	,
cord-277535-u283k70i	204	18	to	to	TO
cord-277535-u283k70i	204	19	discontinue	discontinue	VB
cord-277535-u283k70i	204	20	the	the	DT
cord-277535-u283k70i	204	21	drug	drug	NN
cord-277535-u283k70i	204	22	.	.	.
cord-277535-u283k70i	205	1	Tocilizumab	Tocilizumab	NNP
cord-277535-u283k70i	205	2	:	:	:
cord-277535-u283k70i	206	1	ALT	ALT	NNP
cord-277535-u283k70i	206	2	elevations	elevation	NNS
cord-277535-u283k70i	206	3	are	be	VBP
cord-277535-u283k70i	206	4	frequent	frequent	JJ
cord-277535-u283k70i	206	5	but	but	CC
cord-277535-u283k70i	206	6	fulminant	fulminant	JJ
cord-277535-u283k70i	206	7	hepatitis	hepatitis	NN
cord-277535-u283k70i	206	8	is	be	VBZ
cord-277535-u283k70i	206	9	rare	rare	JJ
cord-277535-u283k70i	206	10	.	.	.
cord-277535-u283k70i	207	1	The	the	DT
cord-277535-u283k70i	207	2	risk	risk	NN
cord-277535-u283k70i	207	3	of	of	IN
cord-277535-u283k70i	207	4	re	re	NN
cord-277535-u283k70i	207	5	activation	activation	NN
cord-277535-u283k70i	207	6	of	of	IN
cord-277535-u283k70i	207	7	HBV	HBV	NNP
cord-277535-u283k70i	207	8	should	should	MD
cord-277535-u283k70i	207	9	be	be	VB
cord-277535-u283k70i	207	10	kept	keep	VBN
cord-277535-u283k70i	207	11	in	in	IN
cord-277535-u283k70i	207	12	mind	mind	NN
cord-277535-u283k70i	207	13	if	if	IN
cord-277535-u283k70i	207	14	patient	patient	JJ
cord-277535-u283k70i	207	15	had	have	VBD
cord-277535-u283k70i	207	16	chronic	chronic	JJ
cord-277535-u283k70i	207	17	liver	liver	NN
cord-277535-u283k70i	207	18	disease	disease	NN
cord-277535-u283k70i	207	19	secondary	secondary	JJ
cord-277535-u283k70i	207	20	to	to	IN
cord-277535-u283k70i	207	21	viral	viral	JJ
cord-277535-u283k70i	207	22	etiology	etiology	NN
cord-277535-u283k70i	207	23	.	.	.
cord-277535-u283k70i	208	1	28	28	CD
cord-277535-u283k70i	208	2	Steriods	Steriods	NNPS
cord-277535-u283k70i	208	3	:	:	:
cord-277535-u283k70i	208	4	low	low	JJ
cord-277535-u283k70i	208	5	dose	dose	NN
cord-277535-u283k70i	208	6	dexamethasone	dexamethasone	NN
cord-277535-u283k70i	208	7	is	be	VBZ
cord-277535-u283k70i	208	8	probably	probably	RB
cord-277535-u283k70i	208	9	safe	safe	JJ
cord-277535-u283k70i	208	10	in	in	IN
cord-277535-u283k70i	208	11	patients	patient	NNS
cord-277535-u283k70i	208	12	with	with	IN
cord-277535-u283k70i	208	13	chronic	chronic	JJ
cord-277535-u283k70i	208	14	stable	stable	JJ
cord-277535-u283k70i	208	15	liver	liver	NN
cord-277535-u283k70i	208	16	diease	diease	NN
cord-277535-u283k70i	208	17	.	.	.
cord-277535-u283k70i	209	1	However	however	RB
cord-277535-u283k70i	209	2	use	use	NN
cord-277535-u283k70i	209	3	of	of	IN
cord-277535-u283k70i	209	4	methylprednisolone	methylprednisolone	NN
cord-277535-u283k70i	209	5	in	in	IN
cord-277535-u283k70i	209	6	high	high	JJ
cord-277535-u283k70i	209	7	doses	dose	NNS
cord-277535-u283k70i	209	8	may	may	MD
cord-277535-u283k70i	209	9	reactivate	reactivate	VB
cord-277535-u283k70i	209	10	HBV	HBV	NNP
cord-277535-u283k70i	209	11	and	and	CC
cord-277535-u283k70i	209	12	increase	increase	VB
cord-277535-u283k70i	209	13	risk	risk	NN
cord-277535-u283k70i	209	14	of	of	IN
cord-277535-u283k70i	209	15	spontaneous	spontaneous	JJ
cord-277535-u283k70i	209	16	bacterial	bacterial	JJ
cord-277535-u283k70i	209	17	peritonitis	peritonitis	NN
cord-277535-u283k70i	209	18	(	(	-LRB-
cord-277535-u283k70i	209	19	SBP	SBP	NNP
cord-277535-u283k70i	209	20	)	)	-RRB-
cord-277535-u283k70i	209	21	in	in	IN
cord-277535-u283k70i	209	22	severe	severe	JJ
cord-277535-u283k70i	209	23	cases	case	NNS
cord-277535-u283k70i	209	24	.	.	.
cord-277535-u283k70i	210	1	28	28	CD
cord-277535-u283k70i	210	2	Hydoxychloroquine	Hydoxychloroquine	NNP
cord-277535-u283k70i	210	3	:	:	:
cord-277535-u283k70i	210	4	data	data	NN
cord-277535-u283k70i	210	5	is	be	VBZ
cord-277535-u283k70i	210	6	limited	limit	VBN
cord-277535-u283k70i	210	7	but	but	CC
cord-277535-u283k70i	210	8	generally	generally	RB
cord-277535-u283k70i	210	9	has	have	VBZ
cord-277535-u283k70i	210	10	not	not	RB
cord-277535-u283k70i	210	11	been	be	VBN
cord-277535-u283k70i	210	12	associated	associate	VBN
cord-277535-u283k70i	210	13	with	with	IN
cord-277535-u283k70i	210	14	elevations	elevation	NNS
cord-277535-u283k70i	210	15	in	in	IN
cord-277535-u283k70i	210	16	ALT	alt	NN
cord-277535-u283k70i	210	17	levels	level	NNS
cord-277535-u283k70i	210	18	and	and	CC
cord-277535-u283k70i	210	19	is	be	VBZ
cord-277535-u283k70i	210	20	an	an	DT
cord-277535-u283k70i	210	21	extremely	extremely	RB
cord-277535-u283k70i	210	22	rare	rare	JJ
cord-277535-u283k70i	210	23	cause	cause	NN
cord-277535-u283k70i	210	24	of	of	IN
cord-277535-u283k70i	210	25	drug	drug	NN
cord-277535-u283k70i	210	26	induced	induce	VBN
cord-277535-u283k70i	210	27	liver	liver	NN
cord-277535-u283k70i	210	28	injury	injury	NN
cord-277535-u283k70i	210	29	.	.	.
cord-277535-u283k70i	211	1	28e31	28e31	CD
cord-277535-u283k70i	212	1	Changing	change	VBG
cord-277535-u283k70i	212	2	patterns	pattern	NNS
cord-277535-u283k70i	212	3	of	of	IN
cord-277535-u283k70i	212	4	causation	causation	NN
cord-277535-u283k70i	212	5	and	and	CC
cord-277535-u283k70i	212	6	the	the	DT
cord-277535-u283k70i	212	7	use	use	NN
cord-277535-u283k70i	212	8	of	of	IN
cord-277535-u283k70i	212	9	transplantation	transplantation	NN
cord-277535-u283k70i	212	10	in	in	IN
cord-277535-u283k70i	212	11	the	the	DT
cord-277535-u283k70i	212	12	United	United	NNP
cord-277535-u283k70i	212	13	Kingdom	Kingdom	NNP
cord-277535-u283k70i	212	14	Drug	Drug	NNP
cord-277535-u283k70i	212	15	dosing	dosing	NN
cord-277535-u283k70i	212	16	considerations	consideration	NNS
cord-277535-u283k70i	212	17	for	for	IN
cord-277535-u283k70i	212	18	the	the	DT
cord-277535-u283k70i	212	19	critically	critically	RB
cord-277535-u283k70i	212	20	ill	ill	JJ
cord-277535-u283k70i	212	21	patient	patient	NN
cord-277535-u283k70i	212	22	with	with	IN
cord-277535-u283k70i	212	23	liver	liver	NN
cord-277535-u283k70i	212	24	disease	disease	NN
cord-277535-u283k70i	212	25	SARS	SARS	NNP
cord-277535-u283k70i	212	26	-	-	HYPH
cord-277535-u283k70i	212	27	CoV-2	CoV-2	NNP
cord-277535-u283k70i	212	28	cell	cell	NN
cord-277535-u283k70i	212	29	entry	entry	NN
cord-277535-u283k70i	212	30	depends	depend	VBZ
cord-277535-u283k70i	212	31	on	on	IN
cord-277535-u283k70i	212	32	ACE2	ACE2	NNP
cord-277535-u283k70i	212	33	and	and	CC
cord-277535-u283k70i	212	34	TMPRSS2	TMPRSS2	NNP
cord-277535-u283k70i	212	35	and	and	CC
cord-277535-u283k70i	212	36	is	be	VBZ
cord-277535-u283k70i	212	37	blocked	block	VBN
cord-277535-u283k70i	212	38	by	by	IN
cord-277535-u283k70i	212	39	a	a	DT
cord-277535-u283k70i	212	40	clinically	clinically	RB
cord-277535-u283k70i	212	41	proven	prove	VBN
cord-277535-u283k70i	212	42	protease	protease	NN
cord-277535-u283k70i	212	43	inhibitor	inhibitor	NN
cord-277535-u283k70i	212	44	Liver	liver	NN
cord-277535-u283k70i	212	45	injury	injury	NN
cord-277535-u283k70i	212	46	in	in	IN
cord-277535-u283k70i	212	47	COVID-19	COVID-19	NNP
cord-277535-u283k70i	212	48	:	:	:
cord-277535-u283k70i	212	49	the	the	DT
cord-277535-u283k70i	212	50	current	current	JJ
cord-277535-u283k70i	212	51	evidence	evidence	NN
cord-277535-u283k70i	212	52	Hypoalbuminemia	Hypoalbuminemia	NNP
cord-277535-u283k70i	212	53	predicts	predict	VBZ
cord-277535-u283k70i	212	54	the	the	DT
cord-277535-u283k70i	212	55	outcome	outcome	NN
cord-277535-u283k70i	212	56	of	of	IN
cord-277535-u283k70i	212	57	COVID-19	COVID-19	NNP
cord-277535-u283k70i	212	58	independent	independent	NN
cord-277535-u283k70i	212	59	of	of	IN
cord-277535-u283k70i	212	60	age	age	NN
cord-277535-u283k70i	212	61	and	and	CC
cord-277535-u283k70i	212	62	co	co	NN
cord-277535-u283k70i	212	63	-	-	JJ
cord-277535-u283k70i	212	64	morbidity	morbidity	JJ
cord-277535-u283k70i	212	65	Liver	liver	NN
cord-277535-u283k70i	212	66	injury	injury	NN
cord-277535-u283k70i	212	67	during	during	IN
cord-277535-u283k70i	212	68	highly	highly	RB
cord-277535-u283k70i	212	69	pathogenic	pathogenic	JJ
cord-277535-u283k70i	212	70	human	human	JJ
cord-277535-u283k70i	212	71	coronavirus	coronavirus	NN
cord-277535-u283k70i	212	72	infections	infection	NNS
cord-277535-u283k70i	212	73	High	high	JJ
cord-277535-u283k70i	212	74	mortality	mortality	NN
cord-277535-u283k70i	212	75	rates	rate	NNS
cord-277535-u283k70i	212	76	for	for	IN
cord-277535-u283k70i	212	77	SARS	SARS	NNP
cord-277535-u283k70i	212	78	-	-	HYPH
cord-277535-u283k70i	212	79	CoV-2	CoV-2	NNP
cord-277535-u283k70i	212	80	infection	infection	NN
cord-277535-u283k70i	212	81	in	in	IN
cord-277535-u283k70i	212	82	patients	patient	NNS
cord-277535-u283k70i	212	83	with	with	IN
cord-277535-u283k70i	212	84	pre	pre	JJ
cord-277535-u283k70i	212	85	-	-	JJ
cord-277535-u283k70i	212	86	existing	existing	JJ
cord-277535-u283k70i	212	87	chronic	chronic	JJ
cord-277535-u283k70i	212	88	liver	liver	NN
cord-277535-u283k70i	212	89	disease	disease	NN
cord-277535-u283k70i	212	90	and	and	CC
cord-277535-u283k70i	212	91	cirrhosis	cirrhosis	NN
cord-277535-u283k70i	212	92	:	:	:
cord-277535-u283k70i	212	93	preliminary	preliminary	JJ
cord-277535-u283k70i	212	94	results	result	NNS
cord-277535-u283k70i	212	95	from	from	IN
cord-277535-u283k70i	212	96	an	an	DT
cord-277535-u283k70i	212	97	international	international	JJ
cord-277535-u283k70i	212	98	registry	registry	NN
cord-277535-u283k70i	212	99	Differentiated	differentiate	VBN
cord-277535-u283k70i	212	100	effects	effect	NNS
cord-277535-u283k70i	212	101	of	of	IN
cord-277535-u283k70i	212	102	liver	liver	NN
cord-277535-u283k70i	212	103	cirrohosis	cirrohosis	NN
cord-277535-u283k70i	212	104	on	on	IN
cord-277535-u283k70i	212	105	albumin	albumin	NN
cord-277535-u283k70i	212	106	binding	bind	VBG
cord-277535-u283k70i	212	107	sites	site	NNS
cord-277535-u283k70i	212	108	for	for	IN
cord-277535-u283k70i	212	109	diazepam	diazepam	NN
cord-277535-u283k70i	212	110	,	,	,
cord-277535-u283k70i	212	111	salicylic	salicylic	JJ
cord-277535-u283k70i	212	112	acid	acid	NN
cord-277535-u283k70i	212	113	and	and	CC
cord-277535-u283k70i	212	114	warfarin	warfarin	NN
cord-277535-u283k70i	212	115	Anaesthesia	Anaesthesia	NNP
cord-277535-u283k70i	212	116	for	for	IN
cord-277535-u283k70i	212	117	the	the	DT
cord-277535-u283k70i	212	118	patient	patient	NN
cord-277535-u283k70i	212	119	with	with	IN
cord-277535-u283k70i	212	120	liver	liver	NN
cord-277535-u283k70i	212	121	disease	disease	NN
cord-277535-u283k70i	213	1	A	a	DT
cord-277535-u283k70i	213	2	model	model	NN
cord-277535-u283k70i	213	3	to	to	TO
cord-277535-u283k70i	213	4	predict	predict	VB
cord-277535-u283k70i	213	5	poor	poor	JJ
cord-277535-u283k70i	213	6	survival	survival	NN
cord-277535-u283k70i	213	7	in	in	IN
cord-277535-u283k70i	213	8	patients	patient	NNS
cord-277535-u283k70i	213	9	undergoing	undergo	VBG
cord-277535-u283k70i	213	10	transjugular	transjugular	NNP
cord-277535-u283k70i	213	11	intrahepatic	intrahepatic	JJ
cord-277535-u283k70i	213	12	portosystemic	portosystemic	JJ
cord-277535-u283k70i	213	13	shunts	shunt	NNS
cord-277535-u283k70i	213	14	MELD	meld	VB
cord-277535-u283k70i	213	15	-	-	HYPH
cord-277535-u283k70i	213	16	Na	Na	NNP
cord-277535-u283k70i	213	17	(	(	-LRB-
cord-277535-u283k70i	213	18	the	the	DT
cord-277535-u283k70i	213	19	new	new	JJ
cord-277535-u283k70i	213	20	MELD	MELD	NNP
cord-277535-u283k70i	213	21	)	)	-RRB-
cord-277535-u283k70i	213	22	and	and	CC
cord-277535-u283k70i	213	23	peri	peri	JJ
cord-277535-u283k70i	213	24	-	-	HYPH
cord-277535-u283k70i	213	25	operative	operative	JJ
cord-277535-u283k70i	213	26	outcomes	outcome	NNS
cord-277535-u283k70i	213	27	in	in	IN
cord-277535-u283k70i	213	28	emergency	emergency	NN
cord-277535-u283k70i	213	29	surgery	surgery	NN
cord-277535-u283k70i	213	30	Buggy	Buggy	NNP
cord-277535-u283k70i	213	31	Donal	Donal	NNP
cord-277535-u283k70i	213	32	J.	J.	NNP
cord-277535-u283k70i	213	33	Pharmacology	Pharmacology	NNP
cord-277535-u283k70i	213	34	of	of	IN
cord-277535-u283k70i	213	35	anaesthetic	anaesthetic	JJ
cord-277535-u283k70i	213	36	agents	agent	NNS
cord-277535-u283k70i	213	37	II	II	NNP
cord-277535-u283k70i	213	38	:	:	:
cord-277535-u283k70i	213	39	inhalation	inhalation	NN
cord-277535-u283k70i	213	40	anaesthetic	anaesthetic	JJ
cord-277535-u283k70i	213	41	agents	agent	NNS
cord-277535-u283k70i	213	42	Anaesthesia	Anaesthesia	NNP
cord-277535-u283k70i	213	43	for	for	IN
cord-277535-u283k70i	213	44	patients	patient	NNS
cord-277535-u283k70i	213	45	with	with	IN
cord-277535-u283k70i	213	46	liver	liver	NN
cord-277535-u283k70i	213	47	disease	disease	NN
cord-277535-u283k70i	214	1	The	the	DT
cord-277535-u283k70i	214	2	effects	effect	NNS
cord-277535-u283k70i	214	3	of	of	IN
cord-277535-u283k70i	214	4	prolonged	prolong	VBN
cord-277535-u283k70i	214	5	lowflow	lowflow	NN
cord-277535-u283k70i	214	6	sevoflurane	sevoflurane	NNP
cord-277535-u283k70i	214	7	anesthesia	anesthesia	NNP
cord-277535-u283k70i	214	8	on	on	IN
cord-277535-u283k70i	214	9	renal	renal	JJ
cord-277535-u283k70i	214	10	and	and	CC
cord-277535-u283k70i	214	11	hepatic	hepatic	JJ
cord-277535-u283k70i	214	12	function	function	NN
cord-277535-u283k70i	214	13	Blood	blood	NN
cord-277535-u283k70i	214	14	supply	supply	NN
cord-277535-u283k70i	214	15	to	to	IN
cord-277535-u283k70i	214	16	the	the	DT
cord-277535-u283k70i	214	17	liver	liver	NN
cord-277535-u283k70i	214	18	in	in	IN
cord-277535-u283k70i	214	19	the	the	DT
cord-277535-u283k70i	214	20	human	human	NN
cord-277535-u283k70i	214	21	after	after	IN
cord-277535-u283k70i	214	22	1	1	CD
cord-277535-u283k70i	214	23	MAC	MAC	NNP
cord-277535-u283k70i	214	24	desflurane	desflurane	NNP
cord-277535-u283k70i	214	25	in	in	IN
cord-277535-u283k70i	214	26	comparison	comparison	NN
cord-277535-u283k70i	214	27	with	with	IN
cord-277535-u283k70i	214	28	isoflurane	isoflurane	NNP
cord-277535-u283k70i	214	29	and	and	CC
cord-277535-u283k70i	214	30	halothane	halothane	NNP
cord-277535-u283k70i	215	1	The	the	DT
cord-277535-u283k70i	215	2	effect	effect	NN
cord-277535-u283k70i	215	3	of	of	IN
cord-277535-u283k70i	215	4	isoflurane	isoflurane	NN
cord-277535-u283k70i	215	5	or	or	CC
cord-277535-u283k70i	215	6	propofol	propofol	NN
cord-277535-u283k70i	215	7	anaesthesia	anaesthesia	NN
cord-277535-u283k70i	215	8	on	on	IN
cord-277535-u283k70i	215	9	liver	liver	NN
cord-277535-u283k70i	215	10	injury	injury	NN
cord-277535-u283k70i	215	11	after	after	IN
cord-277535-u283k70i	215	12	partial	partial	JJ
cord-277535-u283k70i	215	13	hepatectomy	hepatectomy	NN
cord-277535-u283k70i	215	14	in	in	IN
cord-277535-u283k70i	215	15	cirrhotic	cirrhotic	JJ
cord-277535-u283k70i	215	16	patients	patient	NNS
cord-277535-u283k70i	216	1	Comparison	comparison	NN
cord-277535-u283k70i	216	2	of	of	IN
cord-277535-u283k70i	216	3	the	the	DT
cord-277535-u283k70i	216	4	postoperative	postoperative	JJ
cord-277535-u283k70i	216	5	liver	liver	NN
cord-277535-u283k70i	216	6	function	function	NN
cord-277535-u283k70i	216	7	between	between	IN
cord-277535-u283k70i	216	8	total	total	JJ
cord-277535-u283k70i	216	9	intravenous	intravenous	JJ
cord-277535-u283k70i	216	10	anesthesia	anesthesia	NN
cord-277535-u283k70i	216	11	and	and	CC
cord-277535-u283k70i	216	12	inhalation	inhalation	NN
cord-277535-u283k70i	216	13	anesthesia	anesthesia	NN
cord-277535-u283k70i	216	14	in	in	IN
cord-277535-u283k70i	216	15	patients	patient	NNS
cord-277535-u283k70i	216	16	with	with	IN
cord-277535-u283k70i	216	17	preoperatively	preoperatively	RB
cord-277535-u283k70i	216	18	elevated	elevated	JJ
cord-277535-u283k70i	216	19	liver	liver	NN
cord-277535-u283k70i	216	20	transaminase	transaminase	NN
cord-277535-u283k70i	216	21	levels	level	NNS
cord-277535-u283k70i	216	22	:	:	:
cord-277535-u283k70i	217	1	a	a	DT
cord-277535-u283k70i	217	2	retrospective	retrospective	JJ
cord-277535-u283k70i	217	3	cohort	cohort	NN
cord-277535-u283k70i	217	4	study	study	NN
cord-277535-u283k70i	217	5	Pain	Pain	NNP
cord-277535-u283k70i	217	6	management	management	NN
cord-277535-u283k70i	217	7	in	in	IN
cord-277535-u283k70i	217	8	patients	patient	NNS
cord-277535-u283k70i	217	9	with	with	IN
cord-277535-u283k70i	217	10	cirrhosis	cirrhosis	NN
cord-277535-u283k70i	217	11	Analgesics	analgesic	NNS
cord-277535-u283k70i	217	12	in	in	IN
cord-277535-u283k70i	217	13	patients	patient	NNS
cord-277535-u283k70i	217	14	with	with	IN
cord-277535-u283k70i	217	15	hepatic	hepatic	JJ
cord-277535-u283k70i	217	16	impairment	impairment	NN
cord-277535-u283k70i	217	17	:	:	:
cord-277535-u283k70i	217	18	pharmacology	pharmacology	NN
cord-277535-u283k70i	217	19	and	and	CC
cord-277535-u283k70i	217	20	clinical	clinical	JJ
cord-277535-u283k70i	217	21	implications	implication	NNS
cord-277535-u283k70i	217	22	SUGAMMADEX	SUGAMMADEX	NNP
cord-277535-u283k70i	217	23	versus	versus	IN
cord-277535-u283k70i	217	24	neostigmine	neostigmine	NN
cord-277535-u283k70i	217	25	after	after	IN
cord-277535-u283k70i	217	26	ROCURONIUM	ROCURONIUM	NNP
cord-277535-u283k70i	217	27	continuous	continuous	JJ
cord-277535-u283k70i	217	28	infusion	infusion	NN
cord-277535-u283k70i	217	29	in	in	IN
cord-277535-u283k70i	217	30	patients	patient	NNS
cord-277535-u283k70i	217	31	undergoing	undergo	VBG
cord-277535-u283k70i	217	32	liver	liver	NN
cord-277535-u283k70i	217	33	transplantation	transplantation	NN
cord-277535-u283k70i	217	34	Dexmedetomidine	Dexmedetomidine	NNP
cord-277535-u283k70i	217	35	reduces	reduce	VBZ
cord-277535-u283k70i	217	36	intestinal	intestinal	JJ
cord-277535-u283k70i	217	37	and	and	CC
cord-277535-u283k70i	217	38	hepatic	hepatic	JJ
cord-277535-u283k70i	217	39	injury	injury	NN
cord-277535-u283k70i	217	40	after	after	IN
cord-277535-u283k70i	217	41	hepatectomy	hepatectomy	NN
cord-277535-u283k70i	217	42	with	with	IN
cord-277535-u283k70i	217	43	inflow	inflow	JJ
cord-277535-u283k70i	217	44	occlusion	occlusion	NN
cord-277535-u283k70i	217	45	under	under	IN
cord-277535-u283k70i	217	46	general	general	JJ
cord-277535-u283k70i	217	47	anaesthesia	anaesthesia	NN
cord-277535-u283k70i	217	48	:	:	:
cord-277535-u283k70i	217	49	a	a	DT
cord-277535-u283k70i	217	50	randomized	randomized	JJ
cord-277535-u283k70i	217	51	controlled	control	VBN
cord-277535-u283k70i	217	52	trial	trial	NN
cord-277535-u283k70i	217	53	Bile	bile	NN
cord-277535-u283k70i	217	54	acids	acid	NNS
cord-277535-u283k70i	217	55	induce	induce	VBP
cord-277535-u283k70i	217	56	arrhythmias	arrhythmias	RB
cord-277535-u283k70i	217	57	:	:	:
cord-277535-u283k70i	217	58	old	old	JJ
cord-277535-u283k70i	217	59	metabolite	metabolite	NNP
cord-277535-u283k70i	217	60	Office	Office	NNP
cord-277535-u283k70i	217	61	for	for	IN
cord-277535-u283k70i	217	62	National	National	NNP
cord-277535-u283k70i	217	63	Statistics	Statistics	NNPS
cord-277535-u283k70i	217	64	)	)	-RRB-
cord-277535-u283k70i	218	1	Paracetamol	paracetamol	JJ
cord-277535-u283k70i	218	2	overdose	overdose	NN
cord-277535-u283k70i	218	3	:	:	:
cord-277535-u283k70i	218	4	an	an	DT
cord-277535-u283k70i	218	5	evidence	evidence	NN
cord-277535-u283k70i	218	6	based	base	VBN
cord-277535-u283k70i	218	7	flowchart	flowchart	NN
cord-277535-u283k70i	218	8	to	to	TO
cord-277535-u283k70i	218	9	guide	guide	VB
cord-277535-u283k70i	218	10	management	management	NN
cord-277535-u283k70i	218	11	The	the	DT
cord-277535-u283k70i	218	12	therapeutic	therapeutic	JJ
cord-277535-u283k70i	218	13	use	use	NN
cord-277535-u283k70i	218	14	of	of	IN
cord-277535-u283k70i	218	15	analgesics	analgesic	NNS
cord-277535-u283k70i	218	16	in	in	IN
cord-277535-u283k70i	218	17	patients	patient	NNS
cord-277535-u283k70i	218	18	with	with	IN
cord-277535-u283k70i	218	19	liver	liver	NN
cord-277535-u283k70i	218	20	cirrhosis	cirrhosis	NN
cord-277535-u283k70i	218	21	:	:	:
cord-277535-u283k70i	219	1	a	a	DT
cord-277535-u283k70i	219	2	literature	literature	NN
cord-277535-u283k70i	219	3	review	review	NN
cord-277535-u283k70i	219	4	and	and	CC
cord-277535-u283k70i	219	5	evidence	evidence	NN
cord-277535-u283k70i	219	6	-	-	HYPH
cord-277535-u283k70i	219	7	based	base	VBN
cord-277535-u283k70i	219	8	recommendations	recommendation	NNS
cord-277535-u283k70i	219	9	Care	Care	NNP
cord-277535-u283k70i	219	10	of	of	IN
cord-277535-u283k70i	219	11	patients	patient	NNS
cord-277535-u283k70i	219	12	with	with	IN
cord-277535-u283k70i	219	13	liver	liver	NN
cord-277535-u283k70i	219	14	disease	disease	NN
cord-277535-u283k70i	219	15	during	during	IN
cord-277535-u283k70i	219	16	the	the	DT
cord-277535-u283k70i	219	17	COVID-19	COVID-19	NNP
cord-277535-u283k70i	219	18	pandemic	pandemic	NN
cord-277535-u283k70i	219	19	:	:	:
cord-277535-u283k70i	219	20	EASL	EASL	NNP
cord-277535-u283k70i	219	21	-	-	HYPH
cord-277535-u283k70i	219	22	ESCMID	ESCMID	NNP
cord-277535-u283k70i	219	23	position	position	NN
cord-277535-u283k70i	219	24	paper	paper	NN
cord-277535-u283k70i	219	25	Liver	liver	NN
cord-277535-u283k70i	219	26	injury	injury	NN
cord-277535-u283k70i	219	27	in	in	IN
cord-277535-u283k70i	219	28	COVID-19	COVID-19	NNP
cord-277535-u283k70i	219	29	:	:	:
cord-277535-u283k70i	219	30	management	management	NN
cord-277535-u283k70i	219	31	and	and	CC
cord-277535-u283k70i	219	32	challenges	challenge	VBZ
cord-277535-u283k70i	219	33	COVID-19	covid-19	VBP
cord-277535-u283k70i	219	34	:	:	:
cord-277535-u283k70i	219	35	abnormal	abnormal	JJ
cord-277535-u283k70i	219	36	liver	liver	NN
cord-277535-u283k70i	219	37	function	function	NN
cord-277535-u283k70i	219	38	tests	test	VBZ
cord-277535-u283k70i	219	39	Pharmacokinetics	Pharmacokinetics	NNP
cord-277535-u283k70i	219	40	in	in	IN
cord-277535-u283k70i	219	41	disease	disease	NN
cord-277535-u283k70i	219	42	states	state	NNS
cord-277535-u283k70i	219	43	modifying	modify	VBG
cord-277535-u283k70i	219	44	hepatic	hepatic	JJ
cord-277535-u283k70i	219	45	and	and	CC
cord-277535-u283k70i	219	46	metabolic	metabolic	JJ
cord-277535-u283k70i	219	47	function	function	NN