id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303555-mwu72q7w	Dent, Paul	Cell Signaling and Translational Developmental Therapeutics	2020-10-06		.txt	text/plain	8877	556	49	Thus, by the mid-to late-1980s a large body of literature existed which argued that signal transduction pathways consisted of a receptor linked to a large GTP-binding protein which in turn regulated an enzyme that generated "second messengers;" the second messengers would then diffuse throughout the cytosol activating cellular processes, predominantly for metabolism. For the EGFR and other subsequently discovered membrane associated tyrosine kinases, e.g. the non-receptor SCR family and the fibroblast growth factor receptor (FGFR) family, understanding how these enzymes signaled into the cell again initially rested on studies using traditional biochemical methods. [71] [72] [73] [74] [75] [76] Contemporaneously with these studies, researchers were determining how receptor tyrosine kinases regulated RAS family small GTP binding proteins, and other groups determining how RAS proteins signaled downstream off the plasma membrane and into the cytosol.	./cache/cord-303555-mwu72q7w.txt	./txt/cord-303555-mwu72q7w.txt