id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288026-vcp8o5xn	DeStefano, Vincent	Applications of PLA in Modern Medicine	2020-09-06		.txt	text/plain	8592	612	43	PLA has shown promise as a biomaterial in a plethora of healthcare applications such as tissue engineering or regenerative medicine, cardiovascular implants, dental niches, drug carriers, orthopedic interventions, cancer therapy, skin and tendon healing, and lastly medical tools / equipment. Blending with PLA-based stereocomplexed polymers, such as PLLA and PLDA, has demonstrated improved thermal stability and decelerated degradation rate. Manufacturing techniques may take advantage of the strong interactions between PDLA and PLLA blocks, which result from the formation of stereocomplex crystallization as well as improved mechanical properties and thermal stability. Degradation rate is dependent upon a number of factors: polymer composition, pH, device geometry, molecular weight, crystallinity, addition of drugs and/or additives, sterilization, mechanical stress, and fabrication processing. This is likely due to the controlled drug release and enhanced anti-tumor effects seen in doxorubicin-loaded PLA-based scaffolds, such as the one described by Niu et al. Effect of molecular weight and crystallinity on poly(lactic acid) mechanical properties	./cache/cord-288026-vcp8o5xn.txt	./txt/cord-288026-vcp8o5xn.txt