id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257496-mirh80gn	Hickey, Anthony J.	Emerging trends in inhaled drug delivery	2020-07-12		.txt	text/plain	4689	258	42	These product variables in combination with patient variables, including co-ordination skill during inhaler use, intrinsic lung biology, disease and consequent pulmonary function, contribute to drug safety and efficacy outcomes. Figure 1 summarizes the requirements of matching the therapeutic agent to the desired treatment outcome while considering the overall host system barriers (deposition and clearance mechanisms) and target (receptor or pathogen) biology guiding selection or development of a suitable drug delivery technology. However, recently the use of liposomes to aid in drug preparation and delivery and to aid in targeting of macrophages has advanced formulation options [28, 29] .The use of ethanol in the solutions delivered from the Respimat™ soft mist inhaler, e.g. tiotropium (Spiriva®, Boehringer Ingelheim) enhances the solubilization properties of the medium and facilitates a hand held aqueous based system with accurate and reproducible performance in delivering very low doses (<10 µg) on a single breath analogous to a metered dose inhaler [30, 31] . The addition of low-density lipid particles to HFA as a dispersant for micronized drug has allowed for a range of new metered dose inhaler products to come to market [40] .	./cache/cord-257496-mirh80gn.txt	./txt/cord-257496-mirh80gn.txt