id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000204-hd12p867	Wu, Han-Chung	Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy	2010-05-05		.txt	text/plain	4433	217	32	title: Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy One recognized strategy for improving the therapeutic effectiveness of conventional chemotherapeutics is to encapsulate anticancer drugs into targeting liposomes that bind to the cell surface receptors expressed on tumor-associated endothelial cells. This article reviews the current research in developing liposomal drug delivery systems that use peptide ligands to target blood vessels in solid tumors. One peptide-conjugated liposome can deliver over ten thousand anticancer drug molecules directly into target tumor cells efficiently and effectively. In the future, combining ligands that specifically bind to cancer cells (including cancer stem cells) and tumor blood vessels with multifunctional liposomal drug delivery systems may help improve the effectiveness of cancer treatment and minimize the side effects traditionally associated with chemotherapy. The potential use of ligand-conjugated liposome-encapsulated drugs to target tumor cells and vasculature is very promising.	./cache/cord-000204-hd12p867.txt	./txt/cord-000204-hd12p867.txt