id	sid	tid	token	lemma	pos
cord-346853-0c1qdjb5	1	1	key	key	NN
cord-346853-0c1qdjb5	1	2	:	:	:
cord-346853-0c1qdjb5	2	1	cord-346853	cord-346853	NNP
cord-346853-0c1qdjb5	2	2	-	-	HYPH
cord-346853-0c1qdjb5	2	3	0c1qdjb5	0c1qdjb5	CD
cord-346853-0c1qdjb5	2	4	authors	author	NNS
cord-346853-0c1qdjb5	2	5	:	:	:
cord-346853-0c1qdjb5	2	6	Holmes	Holmes	NNP
cord-346853-0c1qdjb5	2	7	,	,	,
cord-346853-0c1qdjb5	2	8	E.	E.	NNP
cord-346853-0c1qdjb5	2	9	C.	C.	NNP
cord-346853-0c1qdjb5	2	10	;	;	:
cord-346853-0c1qdjb5	2	11	Drummond	Drummond	NNP
cord-346853-0c1qdjb5	2	12	,	,	,
cord-346853-0c1qdjb5	2	13	A.	A.	NNP
cord-346853-0c1qdjb5	2	14	J.	J.	NNP
cord-346853-0c1qdjb5	2	15	title	title	NN
cord-346853-0c1qdjb5	2	16	:	:	:
cord-346853-0c1qdjb5	2	17	The	the	DT
cord-346853-0c1qdjb5	2	18	Evolutionary	Evolutionary	NNP
cord-346853-0c1qdjb5	2	19	Genetics	Genetics	NNPS
cord-346853-0c1qdjb5	2	20	of	of	IN
cord-346853-0c1qdjb5	2	21	Viral	Viral	NNP
cord-346853-0c1qdjb5	2	22	Emergence	Emergence	NNP
cord-346853-0c1qdjb5	2	23	date	date	NN
cord-346853-0c1qdjb5	2	24	:	:	:
cord-346853-0c1qdjb5	2	25	2007	2007	CD
cord-346853-0c1qdjb5	2	26	journal	journal	NNP
cord-346853-0c1qdjb5	2	27	:	:	:
cord-346853-0c1qdjb5	3	1	Wildlife	wildlife	NN
cord-346853-0c1qdjb5	3	2	and	and	CC
cord-346853-0c1qdjb5	3	3	Emerging	Emerging	NNP
cord-346853-0c1qdjb5	3	4	Zoonotic	Zoonotic	NNP
cord-346853-0c1qdjb5	3	5	Diseases	Diseases	NNPS
cord-346853-0c1qdjb5	3	6	:	:	:
cord-346853-0c1qdjb5	3	7	The	the	DT
cord-346853-0c1qdjb5	3	8	Biology	Biology	NNP
cord-346853-0c1qdjb5	3	9	,	,	,
cord-346853-0c1qdjb5	3	10	Circumstances	circumstance	NNS
cord-346853-0c1qdjb5	3	11	and	and	CC
cord-346853-0c1qdjb5	3	12	Consequences	consequence	NNS
cord-346853-0c1qdjb5	3	13	of	of	IN
cord-346853-0c1qdjb5	3	14	Cross	Cross	NNP
cord-346853-0c1qdjb5	3	15	-	-	HYPH
cord-346853-0c1qdjb5	3	16	Species	Species	NNP
cord-346853-0c1qdjb5	3	17	Transmission	transmission	NN
cord-346853-0c1qdjb5	3	18	DOI	doi	NN
cord-346853-0c1qdjb5	3	19	:	:	:
cord-346853-0c1qdjb5	3	20	10.1007/978	10.1007/978	CD
cord-346853-0c1qdjb5	3	21	-	-	HYPH
cord-346853-0c1qdjb5	3	22	3	3	CD
cord-346853-0c1qdjb5	3	23	-	-	HYPH
cord-346853-0c1qdjb5	3	24	540	540	CD
cord-346853-0c1qdjb5	3	25	-	-	HYPH
cord-346853-0c1qdjb5	3	26	70962	70962	CD
cord-346853-0c1qdjb5	3	27	-	-	HYPH
cord-346853-0c1qdjb5	3	28	6_3	6_3	CD
cord-346853-0c1qdjb5	4	1	sha	sha	NNP
cord-346853-0c1qdjb5	4	2	:	:	:
cord-346853-0c1qdjb5	4	3	95f661ce374695621257078189a1809f5c5a9579	95f661ce374695621257078189a1809f5c5a9579	CD
cord-346853-0c1qdjb5	4	4	doc_id	doc_id	CD
cord-346853-0c1qdjb5	4	5	:	:	:
cord-346853-0c1qdjb5	5	1	346853	346853	CD
cord-346853-0c1qdjb5	5	2	cord_uid	cord_uid	NNS
cord-346853-0c1qdjb5	5	3	:	:	:
cord-346853-0c1qdjb5	5	4	0c1qdjb5	0c1qdjb5	XX
cord-346853-0c1qdjb5	6	1	Despite	despite	IN
cord-346853-0c1qdjb5	6	2	the	the	DT
cord-346853-0c1qdjb5	6	3	wealth	wealth	NN
cord-346853-0c1qdjb5	6	4	of	of	IN
cord-346853-0c1qdjb5	6	5	data	datum	NNS
cord-346853-0c1qdjb5	6	6	describing	describe	VBG
cord-346853-0c1qdjb5	6	7	the	the	DT
cord-346853-0c1qdjb5	6	8	ecological	ecological	JJ
cord-346853-0c1qdjb5	6	9	factors	factor	NNS
cord-346853-0c1qdjb5	6	10	that	that	WDT
cord-346853-0c1qdjb5	6	11	underpin	underpin	VBP
cord-346853-0c1qdjb5	6	12	viral	viral	JJ
cord-346853-0c1qdjb5	6	13	emergence	emergence	NN
cord-346853-0c1qdjb5	6	14	,	,	,
cord-346853-0c1qdjb5	6	15	little	little	JJ
cord-346853-0c1qdjb5	6	16	is	be	VBZ
cord-346853-0c1qdjb5	6	17	known	know	VBN
cord-346853-0c1qdjb5	6	18	about	about	IN
cord-346853-0c1qdjb5	6	19	the	the	DT
cord-346853-0c1qdjb5	6	20	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	6	21	processes	process	NNS
cord-346853-0c1qdjb5	6	22	that	that	WDT
cord-346853-0c1qdjb5	6	23	allow	allow	VBP
cord-346853-0c1qdjb5	6	24	viruses	virus	NNS
cord-346853-0c1qdjb5	6	25	to	to	TO
cord-346853-0c1qdjb5	6	26	jump	jump	VB
cord-346853-0c1qdjb5	6	27	species	species	NN
cord-346853-0c1qdjb5	6	28	barriers	barrier	NNS
cord-346853-0c1qdjb5	6	29	and	and	CC
cord-346853-0c1qdjb5	6	30	establish	establish	VB
cord-346853-0c1qdjb5	6	31	productive	productive	JJ
cord-346853-0c1qdjb5	6	32	infections	infection	NNS
cord-346853-0c1qdjb5	6	33	in	in	IN
cord-346853-0c1qdjb5	6	34	new	new	JJ
cord-346853-0c1qdjb5	6	35	hosts	host	NNS
cord-346853-0c1qdjb5	6	36	.	.	.
cord-346853-0c1qdjb5	7	1	Understanding	understand	VBG
cord-346853-0c1qdjb5	7	2	the	the	DT
cord-346853-0c1qdjb5	7	3	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	7	4	basis	basis	NN
cord-346853-0c1qdjb5	7	5	to	to	IN
cord-346853-0c1qdjb5	7	6	virus	virus	NN
cord-346853-0c1qdjb5	7	7	emergence	emergence	NN
cord-346853-0c1qdjb5	7	8	is	be	VBZ
cord-346853-0c1qdjb5	7	9	therefore	therefore	RB
cord-346853-0c1qdjb5	7	10	a	a	DT
cord-346853-0c1qdjb5	7	11	key	key	JJ
cord-346853-0c1qdjb5	7	12	research	research	NN
cord-346853-0c1qdjb5	7	13	goal	goal	NN
cord-346853-0c1qdjb5	7	14	and	and	CC
cord-346853-0c1qdjb5	7	15	many	many	JJ
cord-346853-0c1qdjb5	7	16	of	of	IN
cord-346853-0c1qdjb5	7	17	the	the	DT
cord-346853-0c1qdjb5	7	18	debates	debate	NNS
cord-346853-0c1qdjb5	7	19	in	in	IN
cord-346853-0c1qdjb5	7	20	this	this	DT
cord-346853-0c1qdjb5	7	21	area	area	NN
cord-346853-0c1qdjb5	7	22	can	can	MD
cord-346853-0c1qdjb5	7	23	be	be	VB
cord-346853-0c1qdjb5	7	24	considered	consider	VBN
cord-346853-0c1qdjb5	7	25	within	within	IN
cord-346853-0c1qdjb5	7	26	the	the	DT
cord-346853-0c1qdjb5	7	27	rigorous	rigorous	JJ
cord-346853-0c1qdjb5	7	28	theoretical	theoretical	JJ
cord-346853-0c1qdjb5	7	29	framework	framework	NN
cord-346853-0c1qdjb5	7	30	established	establish	VBN
cord-346853-0c1qdjb5	7	31	by	by	IN
cord-346853-0c1qdjb5	7	32	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	7	33	genetics	genetic	NNS
cord-346853-0c1qdjb5	7	34	.	.	.
cord-346853-0c1qdjb5	8	1	In	in	IN
cord-346853-0c1qdjb5	8	2	particular	particular	JJ
cord-346853-0c1qdjb5	8	3	,	,	,
cord-346853-0c1qdjb5	8	4	the	the	DT
cord-346853-0c1qdjb5	8	5	respective	respective	JJ
cord-346853-0c1qdjb5	8	6	roles	role	NNS
cord-346853-0c1qdjb5	8	7	played	play	VBN
cord-346853-0c1qdjb5	8	8	by	by	IN
cord-346853-0c1qdjb5	8	9	natural	natural	JJ
cord-346853-0c1qdjb5	8	10	selection	selection	NN
cord-346853-0c1qdjb5	8	11	and	and	CC
cord-346853-0c1qdjb5	8	12	genetic	genetic	JJ
cord-346853-0c1qdjb5	8	13	drift	drift	NN
cord-346853-0c1qdjb5	8	14	in	in	IN
cord-346853-0c1qdjb5	8	15	shaping	shape	VBG
cord-346853-0c1qdjb5	8	16	genetic	genetic	JJ
cord-346853-0c1qdjb5	8	17	diversity	diversity	NN
cord-346853-0c1qdjb5	8	18	are	be	VBP
cord-346853-0c1qdjb5	8	19	also	also	RB
cord-346853-0c1qdjb5	8	20	of	of	IN
cord-346853-0c1qdjb5	8	21	fundamental	fundamental	JJ
cord-346853-0c1qdjb5	8	22	importance	importance	NN
cord-346853-0c1qdjb5	8	23	for	for	IN
cord-346853-0c1qdjb5	8	24	understanding	understand	VBG
cord-346853-0c1qdjb5	8	25	the	the	DT
cord-346853-0c1qdjb5	8	26	nature	nature	NN
cord-346853-0c1qdjb5	8	27	of	of	IN
cord-346853-0c1qdjb5	8	28	viral	viral	JJ
cord-346853-0c1qdjb5	8	29	emergence	emergence	NN
cord-346853-0c1qdjb5	8	30	.	.	.
cord-346853-0c1qdjb5	9	1	Herein	herein	RB
cord-346853-0c1qdjb5	9	2	,	,	,
cord-346853-0c1qdjb5	9	3	we	-PRON-	PRP
cord-346853-0c1qdjb5	9	4	discuss	discuss	VBP
cord-346853-0c1qdjb5	9	5	whether	whether	IN
cord-346853-0c1qdjb5	9	6	there	there	EX
cord-346853-0c1qdjb5	9	7	are	be	VBP
cord-346853-0c1qdjb5	9	8	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	9	9	rules	rule	NNS
cord-346853-0c1qdjb5	9	10	to	to	IN
cord-346853-0c1qdjb5	9	11	viral	viral	JJ
cord-346853-0c1qdjb5	9	12	emergence	emergence	NN
cord-346853-0c1qdjb5	9	13	,	,	,
cord-346853-0c1qdjb5	9	14	and	and	CC
cord-346853-0c1qdjb5	9	15	especially	especially	RB
cord-346853-0c1qdjb5	9	16	whether	whether	IN
cord-346853-0c1qdjb5	9	17	certain	certain	JJ
cord-346853-0c1qdjb5	9	18	types	type	NNS
cord-346853-0c1qdjb5	9	19	of	of	IN
cord-346853-0c1qdjb5	9	20	virus	virus	NN
cord-346853-0c1qdjb5	9	21	,	,	,
cord-346853-0c1qdjb5	9	22	or	or	CC
cord-346853-0c1qdjb5	9	23	those	those	DT
cord-346853-0c1qdjb5	9	24	that	that	WDT
cord-346853-0c1qdjb5	9	25	infect	infect	VBP
cord-346853-0c1qdjb5	9	26	a	a	DT
cord-346853-0c1qdjb5	9	27	particular	particular	JJ
cord-346853-0c1qdjb5	9	28	type	type	NN
cord-346853-0c1qdjb5	9	29	of	of	IN
cord-346853-0c1qdjb5	9	30	host	host	NN
cord-346853-0c1qdjb5	9	31	species	specie	NNS
cord-346853-0c1qdjb5	9	32	,	,	,
cord-346853-0c1qdjb5	9	33	are	be	VBP
cord-346853-0c1qdjb5	9	34	more	more	RBR
cord-346853-0c1qdjb5	9	35	likely	likely	JJ
cord-346853-0c1qdjb5	9	36	to	to	TO
cord-346853-0c1qdjb5	9	37	emerge	emerge	VB
cord-346853-0c1qdjb5	9	38	than	than	IN
cord-346853-0c1qdjb5	9	39	others	other	NNS
cord-346853-0c1qdjb5	9	40	.	.	.
cord-346853-0c1qdjb5	10	1	We	-PRON-	PRP
cord-346853-0c1qdjb5	10	2	stress	stress	VBP
cord-346853-0c1qdjb5	10	3	the	the	DT
cord-346853-0c1qdjb5	10	4	complex	complex	JJ
cord-346853-0c1qdjb5	10	5	interplay	interplay	NN
cord-346853-0c1qdjb5	10	6	between	between	IN
cord-346853-0c1qdjb5	10	7	rates	rate	NNS
cord-346853-0c1qdjb5	10	8	of	of	IN
cord-346853-0c1qdjb5	10	9	viral	viral	JJ
cord-346853-0c1qdjb5	10	10	evolution	evolution	NN
cord-346853-0c1qdjb5	10	11	and	and	CC
cord-346853-0c1qdjb5	10	12	the	the	DT
cord-346853-0c1qdjb5	10	13	ability	ability	NN
cord-346853-0c1qdjb5	10	14	to	to	TO
cord-346853-0c1qdjb5	10	15	recognize	recognize	VB
cord-346853-0c1qdjb5	10	16	cell	cell	NN
cord-346853-0c1qdjb5	10	17	receptors	receptor	NNS
cord-346853-0c1qdjb5	10	18	from	from	IN
cord-346853-0c1qdjb5	10	19	phylogenetically	phylogenetically	RB
cord-346853-0c1qdjb5	10	20	divergent	divergent	JJ
cord-346853-0c1qdjb5	10	21	host	host	NN
cord-346853-0c1qdjb5	10	22	species	specie	NNS
cord-346853-0c1qdjb5	10	23	.	.	.
cord-346853-0c1qdjb5	11	1	We	-PRON-	PRP
cord-346853-0c1qdjb5	11	2	also	also	RB
cord-346853-0c1qdjb5	11	3	emphasize	emphasize	VBP
cord-346853-0c1qdjb5	11	4	the	the	DT
cord-346853-0c1qdjb5	11	5	current	current	JJ
cord-346853-0c1qdjb5	11	6	lack	lack	NN
cord-346853-0c1qdjb5	11	7	of	of	IN
cord-346853-0c1qdjb5	11	8	convincing	convincing	JJ
cord-346853-0c1qdjb5	11	9	data	datum	NNS
cord-346853-0c1qdjb5	11	10	as	as	IN
cord-346853-0c1qdjb5	11	11	to	to	IN
cord-346853-0c1qdjb5	11	12	whether	whether	IN
cord-346853-0c1qdjb5	11	13	viral	viral	JJ
cord-346853-0c1qdjb5	11	14	emergence	emergence	NN
cord-346853-0c1qdjb5	11	15	requires	require	VBZ
cord-346853-0c1qdjb5	11	16	adaptation	adaptation	NN
cord-346853-0c1qdjb5	11	17	to	to	IN
cord-346853-0c1qdjb5	11	18	the	the	DT
cord-346853-0c1qdjb5	11	19	new	new	JJ
cord-346853-0c1qdjb5	11	20	host	host	NN
cord-346853-0c1qdjb5	11	21	species	specie	NNS
cord-346853-0c1qdjb5	11	22	during	during	IN
cord-346853-0c1qdjb5	11	23	the	the	DT
cord-346853-0c1qdjb5	11	24	early	early	JJ
cord-346853-0c1qdjb5	11	25	stages	stage	NNS
cord-346853-0c1qdjb5	11	26	of	of	IN
cord-346853-0c1qdjb5	11	27	infection	infection	NN
cord-346853-0c1qdjb5	11	28	,	,	,
cord-346853-0c1qdjb5	11	29	or	or	CC
cord-346853-0c1qdjb5	11	30	whether	whether	IN
cord-346853-0c1qdjb5	11	31	it	-PRON-	PRP
cord-346853-0c1qdjb5	11	32	is	be	VBZ
cord-346853-0c1qdjb5	11	33	largely	largely	RB
cord-346853-0c1qdjb5	11	34	a	a	DT
cord-346853-0c1qdjb5	11	35	chance	chance	NN
cord-346853-0c1qdjb5	11	36	process	process	NN
cord-346853-0c1qdjb5	11	37	involving	involve	VBG
cord-346853-0c1qdjb5	11	38	the	the	DT
cord-346853-0c1qdjb5	11	39	transmission	transmission	NN
cord-346853-0c1qdjb5	11	40	of	of	IN
cord-346853-0c1qdjb5	11	41	a	a	DT
cord-346853-0c1qdjb5	11	42	viral	viral	JJ
cord-346853-0c1qdjb5	11	43	strain	strain	NN
cord-346853-0c1qdjb5	11	44	with	with	IN
cord-346853-0c1qdjb5	11	45	the	the	DT
cord-346853-0c1qdjb5	11	46	necessary	necessary	JJ
cord-346853-0c1qdjb5	11	47	genetic	genetic	JJ
cord-346853-0c1qdjb5	11	48	characteristics	characteristic	NNS
cord-346853-0c1qdjb5	11	49	.	.	.
cord-346853-0c1qdjb5	12	1	Until	until	IN
cord-346853-0c1qdjb5	12	2	recently	recently	RB
cord-346853-0c1qdjb5	12	3	,	,	,
cord-346853-0c1qdjb5	12	4	studies	study	NNS
cord-346853-0c1qdjb5	12	5	of	of	IN
cord-346853-0c1qdjb5	12	6	emerging	emerge	VBG
cord-346853-0c1qdjb5	12	7	viruses	virus	NNS
cord-346853-0c1qdjb5	12	8	frequently	frequently	RB
cord-346853-0c1qdjb5	12	9	involved	involve	VBD
cord-346853-0c1qdjb5	12	10	compiling	compile	VBG
cord-346853-0c1qdjb5	12	11	lists	list	NNS
cord-346853-0c1qdjb5	12	12	of	of	IN
cord-346853-0c1qdjb5	12	13	pathogens	pathogen	NNS
cord-346853-0c1qdjb5	12	14	that	that	WDT
cord-346853-0c1qdjb5	12	15	were	be	VBD
cord-346853-0c1qdjb5	12	16	considered	consider	VBN
cord-346853-0c1qdjb5	12	17	new	new	JJ
cord-346853-0c1qdjb5	12	18	to	to	IN
cord-346853-0c1qdjb5	12	19	human	human	JJ
cord-346853-0c1qdjb5	12	20	populations	population	NNS
cord-346853-0c1qdjb5	12	21	or	or	CC
cord-346853-0c1qdjb5	12	22	that	that	WDT
cord-346853-0c1qdjb5	12	23	had	have	VBD
cord-346853-0c1qdjb5	12	24	increased	increase	VBN
cord-346853-0c1qdjb5	12	25	in	in	IN
cord-346853-0c1qdjb5	12	26	frequency	frequency	NN
cord-346853-0c1qdjb5	12	27	and	and	CC
cord-346853-0c1qdjb5	12	28	geographical	geographical	JJ
cord-346853-0c1qdjb5	12	29	range	range	NN
cord-346853-0c1qdjb5	12	30	,	,	,
cord-346853-0c1qdjb5	12	31	and	and	CC
cord-346853-0c1qdjb5	12	32	describing	describe	VBG
cord-346853-0c1qdjb5	12	33	the	the	DT
cord-346853-0c1qdjb5	12	34	ecological	ecological	JJ
cord-346853-0c1qdjb5	12	35	factors	factor	NNS
cord-346853-0c1qdjb5	12	36	responsible	responsible	JJ
cord-346853-0c1qdjb5	12	37	for	for	IN
cord-346853-0c1qdjb5	12	38	their	-PRON-	PRP$
cord-346853-0c1qdjb5	12	39	appearance	appearance	NN
cord-346853-0c1qdjb5	12	40	.	.	.
cord-346853-0c1qdjb5	13	1	Such	such	JJ
cord-346853-0c1qdjb5	13	2	studies	study	NNS
cord-346853-0c1qdjb5	13	3	gave	give	VBD
cord-346853-0c1qdjb5	13	4	particular	particular	JJ
cord-346853-0c1qdjb5	13	5	emphasis	emphasis	NN
cord-346853-0c1qdjb5	13	6	to	to	IN
cord-346853-0c1qdjb5	13	7	how	how	WRB
cord-346853-0c1qdjb5	13	8	changes	change	NNS
cord-346853-0c1qdjb5	13	9	in	in	IN
cord-346853-0c1qdjb5	13	10	human	human	JJ
cord-346853-0c1qdjb5	13	11	ecology	ecology	NN
cord-346853-0c1qdjb5	13	12	,	,	,
cord-346853-0c1qdjb5	13	13	notably	notably	RB
cord-346853-0c1qdjb5	13	14	increases	increase	VBZ
cord-346853-0c1qdjb5	13	15	in	in	IN
cord-346853-0c1qdjb5	13	16	population	population	NN
cord-346853-0c1qdjb5	13	17	size	size	NN
cord-346853-0c1qdjb5	13	18	,	,	,
cord-346853-0c1qdjb5	13	19	modifications	modification	NNS
cord-346853-0c1qdjb5	13	20	in	in	IN
cord-346853-0c1qdjb5	13	21	land	land	NN
cord-346853-0c1qdjb5	13	22	use	use	NN
cord-346853-0c1qdjb5	13	23	,	,	,
cord-346853-0c1qdjb5	13	24	global	global	JJ
cord-346853-0c1qdjb5	13	25	travel	travel	NN
cord-346853-0c1qdjb5	13	26	,	,	,
cord-346853-0c1qdjb5	13	27	and	and	CC
cord-346853-0c1qdjb5	13	28	political	political	JJ
cord-346853-0c1qdjb5	13	29	upheavals	upheaval	NNS
cord-346853-0c1qdjb5	13	30	,	,	,
cord-346853-0c1qdjb5	13	31	had	have	VBD
cord-346853-0c1qdjb5	13	32	been	be	VBN
cord-346853-0c1qdjb5	13	33	responsible	responsible	JJ
cord-346853-0c1qdjb5	13	34	for	for	IN
cord-346853-0c1qdjb5	13	35	an	an	DT
cord-346853-0c1qdjb5	13	36	elevated	elevated	JJ
cord-346853-0c1qdjb5	13	37	burden	burden	NN
cord-346853-0c1qdjb5	13	38	of	of	IN
cord-346853-0c1qdjb5	13	39	infectious	infectious	JJ
cord-346853-0c1qdjb5	13	40	disease	disease	NN
cord-346853-0c1qdjb5	13	41	,	,	,
cord-346853-0c1qdjb5	13	42	often	often	RB
cord-346853-0c1qdjb5	13	43	by	by	IN
cord-346853-0c1qdjb5	13	44	increasing	increase	VBG
cord-346853-0c1qdjb5	13	45	the	the	DT
cord-346853-0c1qdjb5	13	46	proximity	proximity	NN
cord-346853-0c1qdjb5	14	1	and/or	and/or	CC
cord-346853-0c1qdjb5	14	2	density	density	NN
cord-346853-0c1qdjb5	14	3	of	of	IN
cord-346853-0c1qdjb5	14	4	possible	possible	JJ
cord-346853-0c1qdjb5	14	5	reservoir	reservoir	NN
cord-346853-0c1qdjb5	14	6	populations	population	NNS
cord-346853-0c1qdjb5	14	7	(	(	-LRB-
cord-346853-0c1qdjb5	14	8	Morse	Morse	NNP
cord-346853-0c1qdjb5	14	9	1995	1995	CD
cord-346853-0c1qdjb5	14	10	)	)	-RRB-
cord-346853-0c1qdjb5	14	11	.	.	.
cord-346853-0c1qdjb5	15	1	What	what	WP
cord-346853-0c1qdjb5	15	2	was	be	VBD
cord-346853-0c1qdjb5	15	3	largely	largely	RB
cord-346853-0c1qdjb5	15	4	absent	absent	JJ
cord-346853-0c1qdjb5	15	5	from	from	IN
cord-346853-0c1qdjb5	15	6	these	these	DT
cord-346853-0c1qdjb5	15	7	studies	study	NNS
cord-346853-0c1qdjb5	15	8	was	be	VBD
cord-346853-0c1qdjb5	15	9	a	a	DT
cord-346853-0c1qdjb5	15	10	consideration	consideration	NN
cord-346853-0c1qdjb5	15	11	of	of	IN
cord-346853-0c1qdjb5	15	12	the	the	DT
cord-346853-0c1qdjb5	15	13	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	15	14	processes	process	NNS
cord-346853-0c1qdjb5	15	15	that	that	WDT
cord-346853-0c1qdjb5	15	16	underlie	underlie	VBP
cord-346853-0c1qdjb5	15	17	viral	viral	JJ
cord-346853-0c1qdjb5	15	18	emergence	emergence	NN
cord-346853-0c1qdjb5	15	19	(	(	-LRB-
cord-346853-0c1qdjb5	15	20	see	see	VB
cord-346853-0c1qdjb5	15	21	the	the	DT
cord-346853-0c1qdjb5	15	22	chapter	chapter	NN
cord-346853-0c1qdjb5	15	23	by	by	IN
cord-346853-0c1qdjb5	15	24	Childs	Childs	NNP
cord-346853-0c1qdjb5	15	25	et	et	NNP
cord-346853-0c1qdjb5	15	26	al	al	NNP
cord-346853-0c1qdjb5	15	27	.	.	.
cord-346853-0c1qdjb5	16	1	,	,	,
cord-346853-0c1qdjb5	16	2	this	this	DT
cord-346853-0c1qdjb5	16	3	volume	volume	NN
cord-346853-0c1qdjb5	16	4	)	)	-RRB-
cord-346853-0c1qdjb5	16	5	.	.	.
cord-346853-0c1qdjb5	17	1	Indeed	indeed	RB
cord-346853-0c1qdjb5	17	2	,	,	,
cord-346853-0c1qdjb5	17	3	the	the	DT
cord-346853-0c1qdjb5	17	4	main	main	JJ
cord-346853-0c1qdjb5	17	5	role	role	NN
cord-346853-0c1qdjb5	17	6	played	play	VBN
cord-346853-0c1qdjb5	17	7	by	by	IN
cord-346853-0c1qdjb5	17	8	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	17	9	biology	biology	NN
cord-346853-0c1qdjb5	17	10	in	in	IN
cord-346853-0c1qdjb5	17	11	the	the	DT
cord-346853-0c1qdjb5	17	12	first	first	JJ
cord-346853-0c1qdjb5	17	13	studies	study	NNS
cord-346853-0c1qdjb5	17	14	of	of	IN
cord-346853-0c1qdjb5	17	15	emerging	emerge	VBG
cord-346853-0c1qdjb5	17	16	viruses	virus	NNS
cord-346853-0c1qdjb5	17	17	was	be	VBD
cord-346853-0c1qdjb5	17	18	to	to	TO
cord-346853-0c1qdjb5	17	19	reconstruct	reconstruct	VB
cord-346853-0c1qdjb5	17	20	the	the	DT
cord-346853-0c1qdjb5	17	21	origin	origin	NN
cord-346853-0c1qdjb5	17	22	and	and	CC
cord-346853-0c1qdjb5	17	23	spread	spread	NN
cord-346853-0c1qdjb5	17	24	of	of	IN
cord-346853-0c1qdjb5	17	25	new	new	JJ
cord-346853-0c1qdjb5	17	26	pathogens	pathogen	NNS
cord-346853-0c1qdjb5	17	27	,	,	,
cord-346853-0c1qdjb5	17	28	largely	largely	RB
cord-346853-0c1qdjb5	17	29	through	through	IN
cord-346853-0c1qdjb5	17	30	phylogenetic	phylogenetic	JJ
cord-346853-0c1qdjb5	17	31	analysis	analysis	NN
cord-346853-0c1qdjb5	17	32	(	(	-LRB-
cord-346853-0c1qdjb5	17	33	for	for	IN
cord-346853-0c1qdjb5	17	34	example	example	NN
cord-346853-0c1qdjb5	18	1	,	,	,
cord-346853-0c1qdjb5	18	2	Nichol	Nichol	NNP
cord-346853-0c1qdjb5	18	3	et	et	NNP
cord-346853-0c1qdjb5	18	4	al	al	NNP
cord-346853-0c1qdjb5	18	5	.	.	.
cord-346853-0c1qdjb5	18	6	1993	1993	CD
cord-346853-0c1qdjb5	18	7	)	)	-RRB-
cord-346853-0c1qdjb5	19	1	.	.	.
cord-346853-0c1qdjb5	20	1	Although	although	IN
cord-346853-0c1qdjb5	20	2	the	the	DT
cord-346853-0c1qdjb5	20	3	focus	focus	NN
cord-346853-0c1qdjb5	20	4	on	on	IN
cord-346853-0c1qdjb5	20	5	changing	change	VBG
cord-346853-0c1qdjb5	20	6	human	human	JJ
cord-346853-0c1qdjb5	20	7	ecology	ecology	NN
cord-346853-0c1qdjb5	20	8	and	and	CC
cord-346853-0c1qdjb5	20	9	phylogenetic	phylogenetic	JJ
cord-346853-0c1qdjb5	20	10	history	history	NN
cord-346853-0c1qdjb5	20	11	was	be	VBD
cord-346853-0c1qdjb5	20	12	an	an	DT
cord-346853-0c1qdjb5	20	13	important	important	JJ
cord-346853-0c1qdjb5	20	14	and	and	CC
cord-346853-0c1qdjb5	20	15	necessary	necessary	JJ
cord-346853-0c1qdjb5	20	16	first	first	JJ
cord-346853-0c1qdjb5	20	17	step	step	NN
cord-346853-0c1qdjb5	20	18	,	,	,
cord-346853-0c1qdjb5	20	19	and	and	CC
cord-346853-0c1qdjb5	20	20	it	-PRON-	PRP
cord-346853-0c1qdjb5	20	21	will	will	MD
cord-346853-0c1qdjb5	20	22	often	often	RB
cord-346853-0c1qdjb5	20	23	be	be	VB
cord-346853-0c1qdjb5	20	24	impossible	impossible	JJ
cord-346853-0c1qdjb5	20	25	to	to	TO
cord-346853-0c1qdjb5	20	26	disentangle	disentangle	VB
cord-346853-0c1qdjb5	20	27	ecology	ecology	NN
cord-346853-0c1qdjb5	20	28	and	and	CC
cord-346853-0c1qdjb5	20	29	genetics	genetics	NN
cord-346853-0c1qdjb5	20	30	when	when	WRB
cord-346853-0c1qdjb5	20	31	explaining	explain	VBG
cord-346853-0c1qdjb5	20	32	the	the	DT
cord-346853-0c1qdjb5	20	33	emergence	emergence	NN
cord-346853-0c1qdjb5	20	34	of	of	IN
cord-346853-0c1qdjb5	20	35	a	a	DT
cord-346853-0c1qdjb5	20	36	specific	specific	JJ
cord-346853-0c1qdjb5	20	37	pathogen	pathogen	NN
cord-346853-0c1qdjb5	20	38	,	,	,
cord-346853-0c1qdjb5	20	39	it	-PRON-	PRP
cord-346853-0c1qdjb5	20	40	is	be	VBZ
cord-346853-0c1qdjb5	20	41	also	also	RB
cord-346853-0c1qdjb5	20	42	essential	essential	JJ
cord-346853-0c1qdjb5	20	43	to	to	TO
cord-346853-0c1qdjb5	20	44	ask	ask	VB
cord-346853-0c1qdjb5	20	45	what	what	WP
cord-346853-0c1qdjb5	20	46	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	20	47	processes	process	NNS
cord-346853-0c1qdjb5	20	48	are	be	VBP
cord-346853-0c1qdjb5	20	49	responsible	responsible	JJ
cord-346853-0c1qdjb5	20	50	for	for	IN
cord-346853-0c1qdjb5	20	51	the	the	DT
cord-346853-0c1qdjb5	20	52	appearance	appearance	NN
cord-346853-0c1qdjb5	20	53	and	and	CC
cord-346853-0c1qdjb5	20	54	spread	spread	NN
cord-346853-0c1qdjb5	20	55	of	of	IN
cord-346853-0c1qdjb5	20	56	pathogens	pathogen	NNS
cord-346853-0c1qdjb5	20	57	?	?	.
cord-346853-0c1qdjb5	21	1	Indeed	indeed	RB
cord-346853-0c1qdjb5	21	2	,	,	,
cord-346853-0c1qdjb5	21	3	for	for	IN
cord-346853-0c1qdjb5	21	4	the	the	DT
cord-346853-0c1qdjb5	21	5	study	study	NN
cord-346853-0c1qdjb5	21	6	of	of	IN
cord-346853-0c1qdjb5	21	7	emerging	emerge	VBG
cord-346853-0c1qdjb5	21	8	viruses	virus	NNS
cord-346853-0c1qdjb5	21	9	to	to	TO
cord-346853-0c1qdjb5	21	10	come	come	VB
cord-346853-0c1qdjb5	21	11	of	of	IN
cord-346853-0c1qdjb5	21	12	age	age	NN
cord-346853-0c1qdjb5	21	13	,	,	,
cord-346853-0c1qdjb5	21	14	it	-PRON-	PRP
cord-346853-0c1qdjb5	21	15	is	be	VBZ
cord-346853-0c1qdjb5	21	16	critical	critical	JJ
cord-346853-0c1qdjb5	21	17	to	to	TO
cord-346853-0c1qdjb5	21	18	determine	determine	VB
cord-346853-0c1qdjb5	21	19	whether	whether	IN
cord-346853-0c1qdjb5	21	20	there	there	EX
cord-346853-0c1qdjb5	21	21	are	be	VBP
cord-346853-0c1qdjb5	21	22	any	any	DT
cord-346853-0c1qdjb5	21	23	general	general	JJ
cord-346853-0c1qdjb5	21	24	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	21	25	rules	rule	NNS
cord-346853-0c1qdjb5	21	26	governing	govern	VBG
cord-346853-0c1qdjb5	21	27	the	the	DT
cord-346853-0c1qdjb5	21	28	process	process	NN
cord-346853-0c1qdjb5	21	29	of	of	IN
cord-346853-0c1qdjb5	21	30	emergence	emergence	NN
cord-346853-0c1qdjb5	21	31	.	.	.
cord-346853-0c1qdjb5	22	1	Evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	22	2	genetics	genetic	NNS
cord-346853-0c1qdjb5	22	3	aims	aim	VBZ
cord-346853-0c1qdjb5	22	4	to	to	TO
cord-346853-0c1qdjb5	22	5	understand	understand	VB
cord-346853-0c1qdjb5	22	6	the	the	DT
cord-346853-0c1qdjb5	22	7	processes	process	NNS
cord-346853-0c1qdjb5	22	8	responsible	responsible	JJ
cord-346853-0c1qdjb5	22	9	for	for	IN
cord-346853-0c1qdjb5	22	10	the	the	DT
cord-346853-0c1qdjb5	22	11	origin	origin	NN
cord-346853-0c1qdjb5	22	12	and	and	CC
cord-346853-0c1qdjb5	22	13	maintenance	maintenance	NN
cord-346853-0c1qdjb5	22	14	of	of	IN
cord-346853-0c1qdjb5	22	15	genetic	genetic	JJ
cord-346853-0c1qdjb5	22	16	variation	variation	NN
cord-346853-0c1qdjb5	22	17	in	in	IN
cord-346853-0c1qdjb5	22	18	populations	population	NNS
cord-346853-0c1qdjb5	22	19	.	.	.
cord-346853-0c1qdjb5	23	1	The	the	DT
cord-346853-0c1qdjb5	23	2	great	great	JJ
cord-346853-0c1qdjb5	23	3	obsession	obsession	NN
cord-346853-0c1qdjb5	23	4	of	of	IN
cord-346853-0c1qdjb5	23	5	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	23	6	genetics	genetic	NNS
cord-346853-0c1qdjb5	23	7	has	have	VBZ
cord-346853-0c1qdjb5	23	8	been	be	VBN
cord-346853-0c1qdjb5	23	9	to	to	TO
cord-346853-0c1qdjb5	23	10	reveal	reveal	VB
cord-346853-0c1qdjb5	23	11	the	the	DT
cord-346853-0c1qdjb5	23	12	respective	respective	JJ
cord-346853-0c1qdjb5	23	13	roles	role	NNS
cord-346853-0c1qdjb5	23	14	of	of	IN
cord-346853-0c1qdjb5	23	15	random	random	JJ
cord-346853-0c1qdjb5	23	16	fluctuations	fluctuation	NNS
cord-346853-0c1qdjb5	23	17	in	in	IN
cord-346853-0c1qdjb5	23	18	allele	allele	NN
cord-346853-0c1qdjb5	23	19	frequencies	frequency	NNS
cord-346853-0c1qdjb5	23	20	-	-	:
cord-346853-0c1qdjb5	23	21	genetic	genetic	JJ
cord-346853-0c1qdjb5	23	22	drift	drift	NN
cord-346853-0c1qdjb5	23	23	-	-	:
cord-346853-0c1qdjb5	23	24	and	and	CC
cord-346853-0c1qdjb5	23	25	the	the	DT
cord-346853-0c1qdjb5	23	26	natural	natural	JJ
cord-346853-0c1qdjb5	23	27	selection	selection	NN
cord-346853-0c1qdjb5	23	28	of	of	IN
cord-346853-0c1qdjb5	23	29	advantageous	advantageous	JJ
cord-346853-0c1qdjb5	23	30	mutations	mutation	NNS
cord-346853-0c1qdjb5	23	31	in	in	IN
cord-346853-0c1qdjb5	23	32	shaping	shape	VBG
cord-346853-0c1qdjb5	23	33	genetic	genetic	JJ
cord-346853-0c1qdjb5	23	34	diversity	diversity	NN
cord-346853-0c1qdjb5	23	35	(	(	-LRB-
cord-346853-0c1qdjb5	23	36	Gillespie	Gillespie	NNP
cord-346853-0c1qdjb5	23	37	1998	1998	CD
cord-346853-0c1qdjb5	23	38	)	)	-RRB-
cord-346853-0c1qdjb5	23	39	.	.	.
cord-346853-0c1qdjb5	24	1	Although	although	IN
cord-346853-0c1qdjb5	24	2	,	,	,
cord-346853-0c1qdjb5	24	3	at	at	IN
cord-346853-0c1qdjb5	24	4	face	face	NN
cord-346853-0c1qdjb5	24	5	value	value	NN
cord-346853-0c1qdjb5	24	6	,	,	,
cord-346853-0c1qdjb5	24	7	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	24	8	genetics	genetic	NNS
cord-346853-0c1qdjb5	24	9	may	may	MD
cord-346853-0c1qdjb5	24	10	seem	seem	VB
cord-346853-0c1qdjb5	24	11	of	of	IN
cord-346853-0c1qdjb5	24	12	little	little	JJ
cord-346853-0c1qdjb5	24	13	relevance	relevance	NN
cord-346853-0c1qdjb5	24	14	to	to	IN
cord-346853-0c1qdjb5	24	15	the	the	DT
cord-346853-0c1qdjb5	24	16	problem	problem	NN
cord-346853-0c1qdjb5	24	17	of	of	IN
cord-346853-0c1qdjb5	24	18	viral	viral	JJ
cord-346853-0c1qdjb5	24	19	emergence	emergence	NN
cord-346853-0c1qdjb5	24	20	,	,	,
cord-346853-0c1qdjb5	24	21	we	-PRON-	PRP
cord-346853-0c1qdjb5	24	22	suggest	suggest	VBP
cord-346853-0c1qdjb5	24	23	that	that	IN
cord-346853-0c1qdjb5	24	24	it	-PRON-	PRP
cord-346853-0c1qdjb5	24	25	in	in	IN
cord-346853-0c1qdjb5	24	26	fact	fact	NN
cord-346853-0c1qdjb5	24	27	provides	provide	VBZ
cord-346853-0c1qdjb5	24	28	an	an	DT
cord-346853-0c1qdjb5	24	29	essential	essential	JJ
cord-346853-0c1qdjb5	24	30	theoretical	theoretical	JJ
cord-346853-0c1qdjb5	24	31	framework	framework	NN
cord-346853-0c1qdjb5	24	32	.	.	.
cord-346853-0c1qdjb5	25	1	For	for	IN
cord-346853-0c1qdjb5	25	2	example	example	NN
cord-346853-0c1qdjb5	25	3	,	,	,
cord-346853-0c1qdjb5	25	4	it	-PRON-	PRP
cord-346853-0c1qdjb5	25	5	might	may	MD
cord-346853-0c1qdjb5	25	6	be	be	VB
cord-346853-0c1qdjb5	25	7	that	that	IN
cord-346853-0c1qdjb5	25	8	emergence	emergence	NN
cord-346853-0c1qdjb5	25	9	simply	simply	RB
cord-346853-0c1qdjb5	25	10	requires	require	VBZ
cord-346853-0c1qdjb5	25	11	the	the	DT
cord-346853-0c1qdjb5	25	12	chance	chance	NN
cord-346853-0c1qdjb5	25	13	exposure	exposure	NN
cord-346853-0c1qdjb5	25	14	of	of	IN
cord-346853-0c1qdjb5	25	15	a	a	DT
cord-346853-0c1qdjb5	25	16	virus	virus	NN
cord-346853-0c1qdjb5	25	17	to	to	IN
cord-346853-0c1qdjb5	25	18	a	a	DT
cord-346853-0c1qdjb5	25	19	new	new	JJ
cord-346853-0c1qdjb5	25	20	susceptible	susceptible	JJ
cord-346853-0c1qdjb5	25	21	population	population	NN
cord-346853-0c1qdjb5	25	22	,	,	,
cord-346853-0c1qdjb5	25	23	with	with	IN
cord-346853-0c1qdjb5	25	24	little	little	JJ
cord-346853-0c1qdjb5	25	25	involvement	involvement	NN
cord-346853-0c1qdjb5	25	26	of	of	IN
cord-346853-0c1qdjb5	25	27	natural	natural	JJ
cord-346853-0c1qdjb5	25	28	selection	selection	NN
cord-346853-0c1qdjb5	25	29	.	.	.
cord-346853-0c1qdjb5	26	1	Alternatively	alternatively	RB
cord-346853-0c1qdjb5	26	2	,	,	,
cord-346853-0c1qdjb5	26	3	it	-PRON-	PRP
cord-346853-0c1qdjb5	26	4	may	may	MD
cord-346853-0c1qdjb5	26	5	be	be	VB
cord-346853-0c1qdjb5	26	6	that	that	IN
cord-346853-0c1qdjb5	26	7	viruses	virus	NNS
cord-346853-0c1qdjb5	26	8	have	have	VBP
cord-346853-0c1qdjb5	26	9	to	to	TO
cord-346853-0c1qdjb5	26	10	adapt	adapt	VB
cord-346853-0c1qdjb5	26	11	to	to	TO
cord-346853-0c1qdjb5	26	12	successfully	successfully	RB
cord-346853-0c1qdjb5	26	13	spread	spread	VB
cord-346853-0c1qdjb5	26	14	in	in	IN
cord-346853-0c1qdjb5	26	15	a	a	DT
cord-346853-0c1qdjb5	26	16	new	new	JJ
cord-346853-0c1qdjb5	26	17	species	specie	NNS
cord-346853-0c1qdjb5	26	18	.	.	.
cord-346853-0c1qdjb5	27	1	In	in	IN
cord-346853-0c1qdjb5	27	2	this	this	DT
cord-346853-0c1qdjb5	27	3	scenario	scenario	NN
cord-346853-0c1qdjb5	27	4	,	,	,
cord-346853-0c1qdjb5	27	5	different	different	JJ
cord-346853-0c1qdjb5	27	6	species	specie	NNS
cord-346853-0c1qdjb5	27	7	might	may	MD
cord-346853-0c1qdjb5	27	8	represent	represent	VB
cord-346853-0c1qdjb5	27	9	different	different	JJ
cord-346853-0c1qdjb5	27	10	fitness	fitness	NN
cord-346853-0c1qdjb5	27	11	peaks	peak	NNS
cord-346853-0c1qdjb5	27	12	on	on	IN
cord-346853-0c1qdjb5	27	13	an	an	DT
cord-346853-0c1qdjb5	27	14	"	"	``
cord-346853-0c1qdjb5	27	15	adaptive	adaptive	JJ
cord-346853-0c1qdjb5	27	16	landscape	landscape	NN
cord-346853-0c1qdjb5	27	17	"	"	''
cord-346853-0c1qdjb5	27	18	and	and	CC
cord-346853-0c1qdjb5	27	19	that	that	IN
cord-346853-0c1qdjb5	27	20	traversing	traverse	VBG
cord-346853-0c1qdjb5	27	21	between	between	IN
cord-346853-0c1qdjb5	27	22	these	these	DT
cord-346853-0c1qdjb5	27	23	peaks	peak	NNS
cord-346853-0c1qdjb5	27	24	is	be	VBZ
cord-346853-0c1qdjb5	27	25	difficult	difficult	JJ
cord-346853-0c1qdjb5	27	26	because	because	IN
cord-346853-0c1qdjb5	27	27	they	-PRON-	PRP
cord-346853-0c1qdjb5	27	28	are	be	VBP
cord-346853-0c1qdjb5	27	29	connected	connect	VBN
cord-346853-0c1qdjb5	27	30	by	by	IN
cord-346853-0c1qdjb5	27	31	valleys	valley	NNS
cord-346853-0c1qdjb5	27	32	of	of	IN
cord-346853-0c1qdjb5	27	33	low	low	JJ
cord-346853-0c1qdjb5	27	34	fitness	fitness	NN
cord-346853-0c1qdjb5	27	35	.	.	.
cord-346853-0c1qdjb5	28	1	Moreover	moreover	RB
cord-346853-0c1qdjb5	28	2	,	,	,
cord-346853-0c1qdjb5	28	3	because	because	IN
cord-346853-0c1qdjb5	28	4	an	an	DT
cord-346853-0c1qdjb5	28	5	emergent	emergent	JJ
cord-346853-0c1qdjb5	28	6	virus	virus	NN
cord-346853-0c1qdjb5	28	7	will	will	MD
cord-346853-0c1qdjb5	28	8	only	only	RB
cord-346853-0c1qdjb5	28	9	infect	infect	VB
cord-346853-0c1qdjb5	28	10	a	a	DT
cord-346853-0c1qdjb5	28	11	small	small	JJ
cord-346853-0c1qdjb5	28	12	number	number	NN
cord-346853-0c1qdjb5	28	13	of	of	IN
cord-346853-0c1qdjb5	28	14	individuals	individual	NNS
cord-346853-0c1qdjb5	28	15	when	when	WRB
cord-346853-0c1qdjb5	28	16	it	-PRON-	PRP
cord-346853-0c1qdjb5	28	17	first	first	RB
cord-346853-0c1qdjb5	28	18	enters	enter	VBZ
cord-346853-0c1qdjb5	28	19	a	a	DT
cord-346853-0c1qdjb5	28	20	new	new	JJ
cord-346853-0c1qdjb5	28	21	population	population	NN
cord-346853-0c1qdjb5	28	22	,	,	,
cord-346853-0c1qdjb5	28	23	genetic	genetic	JJ
cord-346853-0c1qdjb5	28	24	drift	drift	NN
cord-346853-0c1qdjb5	28	25	is	be	VBZ
cord-346853-0c1qdjb5	28	26	expected	expect	VBN
cord-346853-0c1qdjb5	28	27	to	to	TO
cord-346853-0c1qdjb5	28	28	play	play	VB
cord-346853-0c1qdjb5	28	29	a	a	DT
cord-346853-0c1qdjb5	28	30	major	major	JJ
cord-346853-0c1qdjb5	28	31	role	role	NN
cord-346853-0c1qdjb5	28	32	in	in	IN
cord-346853-0c1qdjb5	28	33	determining	determine	VBG
cord-346853-0c1qdjb5	28	34	what	what	WP
cord-346853-0c1qdjb5	28	35	viral	viral	JJ
cord-346853-0c1qdjb5	28	36	mutations	mutation	NNS
cord-346853-0c1qdjb5	28	37	get	get	VBP
cord-346853-0c1qdjb5	28	38	fixed	fix	VBN
cord-346853-0c1qdjb5	28	39	,	,	,
cord-346853-0c1qdjb5	28	40	because	because	IN
cord-346853-0c1qdjb5	28	41	drift	drift	NN
cord-346853-0c1qdjb5	28	42	is	be	VBZ
cord-346853-0c1qdjb5	28	43	more	more	RBR
cord-346853-0c1qdjb5	28	44	potent	potent	JJ
cord-346853-0c1qdjb5	28	45	in	in	IN
cord-346853-0c1qdjb5	28	46	small	small	JJ
cord-346853-0c1qdjb5	28	47	populations	population	NNS
cord-346853-0c1qdjb5	28	48	.	.	.
cord-346853-0c1qdjb5	29	1	Finally	finally	RB
cord-346853-0c1qdjb5	29	2	,	,	,
cord-346853-0c1qdjb5	29	3	the	the	DT
cord-346853-0c1qdjb5	29	4	respective	respective	JJ
cord-346853-0c1qdjb5	29	5	influences	influence	NNS
cord-346853-0c1qdjb5	29	6	of	of	IN
cord-346853-0c1qdjb5	29	7	drift	drift	NN
cord-346853-0c1qdjb5	29	8	and	and	CC
cord-346853-0c1qdjb5	29	9	selection	selection	NN
cord-346853-0c1qdjb5	29	10	will	will	MD
cord-346853-0c1qdjb5	29	11	also	also	RB
cord-346853-0c1qdjb5	29	12	vary	vary	VB
cord-346853-0c1qdjb5	29	13	according	accord	VBG
cord-346853-0c1qdjb5	29	14	to	to	IN
cord-346853-0c1qdjb5	29	15	the	the	DT
cord-346853-0c1qdjb5	29	16	size	size	NN
cord-346853-0c1qdjb5	29	17	of	of	IN
cord-346853-0c1qdjb5	29	18	the	the	DT
cord-346853-0c1qdjb5	29	19	population	population	NN
cord-346853-0c1qdjb5	29	20	bottleneck	bottleneck	NN
cord-346853-0c1qdjb5	29	21	that	that	WDT
cord-346853-0c1qdjb5	29	22	accompanies	accompany	VBZ
cord-346853-0c1qdjb5	29	23	viral	viral	JJ
cord-346853-0c1qdjb5	29	24	transmission	transmission	NN
cord-346853-0c1qdjb5	29	25	among	among	IN
cord-346853-0c1qdjb5	29	26	hosts	host	NNS
cord-346853-0c1qdjb5	29	27	,	,	,
cord-346853-0c1qdjb5	29	28	which	which	WDT
cord-346853-0c1qdjb5	29	29	will	will	MD
cord-346853-0c1qdjb5	29	30	itself	-PRON-	PRP
cord-346853-0c1qdjb5	29	31	be	be	VB
cord-346853-0c1qdjb5	29	32	a	a	DT
cord-346853-0c1qdjb5	29	33	function	function	NN
cord-346853-0c1qdjb5	29	34	of	of	IN
cord-346853-0c1qdjb5	29	35	the	the	DT
cord-346853-0c1qdjb5	29	36	mode	mode	NN
cord-346853-0c1qdjb5	29	37	of	of	IN
cord-346853-0c1qdjb5	29	38	transmission	transmission	NN
cord-346853-0c1qdjb5	29	39	.	.	.
cord-346853-0c1qdjb5	30	1	In	in	IN
cord-346853-0c1qdjb5	30	2	this	this	DT
cord-346853-0c1qdjb5	30	3	paper	paper	NN
cord-346853-0c1qdjb5	30	4	we	-PRON-	PRP
cord-346853-0c1qdjb5	30	5	address	address	VBP
cord-346853-0c1qdjb5	30	6	some	some	DT
cord-346853-0c1qdjb5	30	7	of	of	IN
cord-346853-0c1qdjb5	30	8	the	the	DT
cord-346853-0c1qdjb5	30	9	key	key	JJ
cord-346853-0c1qdjb5	30	10	questions	question	NNS
cord-346853-0c1qdjb5	30	11	surrounding	surround	VBG
cord-346853-0c1qdjb5	30	12	the	the	DT
cord-346853-0c1qdjb5	30	13	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	30	14	genetics	genetic	NNS
cord-346853-0c1qdjb5	30	15	of	of	IN
cord-346853-0c1qdjb5	30	16	viral	viral	JJ
cord-346853-0c1qdjb5	30	17	emergence	emergence	NN
cord-346853-0c1qdjb5	30	18	.	.	.
cord-346853-0c1qdjb5	31	1	Although	although	IN
cord-346853-0c1qdjb5	31	2	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	31	3	genetics	genetics	NN
cord-346853-0c1qdjb5	31	4	relates	relate	VBZ
cord-346853-0c1qdjb5	31	5	equally	equally	RB
cord-346853-0c1qdjb5	31	6	well	well	RB
cord-346853-0c1qdjb5	31	7	to	to	IN
cord-346853-0c1qdjb5	31	8	hosts	host	NNS
cord-346853-0c1qdjb5	31	9	(	(	-LRB-
cord-346853-0c1qdjb5	31	10	such	such	JJ
cord-346853-0c1qdjb5	31	11	as	as	IN
cord-346853-0c1qdjb5	31	12	differences	difference	NNS
cord-346853-0c1qdjb5	31	13	in	in	IN
cord-346853-0c1qdjb5	31	14	susceptibility	susceptibility	NN
cord-346853-0c1qdjb5	31	15	and	and	CC
cord-346853-0c1qdjb5	31	16	immune	immune	JJ
cord-346853-0c1qdjb5	31	17	responses	response	NNS
cord-346853-0c1qdjb5	31	18	)	)	-RRB-
cord-346853-0c1qdjb5	31	19	as	as	RB
cord-346853-0c1qdjb5	31	20	well	well	RB
cord-346853-0c1qdjb5	31	21	as	as	IN
cord-346853-0c1qdjb5	31	22	pathogens	pathogen	NNS
cord-346853-0c1qdjb5	31	23	,	,	,
cord-346853-0c1qdjb5	31	24	we	-PRON-	PRP
cord-346853-0c1qdjb5	31	25	will	will	MD
cord-346853-0c1qdjb5	31	26	concentrate	concentrate	VB
cord-346853-0c1qdjb5	31	27	on	on	IN
cord-346853-0c1qdjb5	31	28	the	the	DT
cord-346853-0c1qdjb5	31	29	latter	latter	JJ
cord-346853-0c1qdjb5	31	30	where	where	WRB
cord-346853-0c1qdjb5	31	31	data	data	NN
cord-346853-0c1qdjb5	31	32	is	be	VBZ
cord-346853-0c1qdjb5	31	33	more	more	RBR
cord-346853-0c1qdjb5	31	34	abundant	abundant	JJ
cord-346853-0c1qdjb5	31	35	and	and	CC
cord-346853-0c1qdjb5	31	36	their	-PRON-	PRP$
cord-346853-0c1qdjb5	31	37	evolution	evolution	NN
cord-346853-0c1qdjb5	31	38	can	can	MD
cord-346853-0c1qdjb5	31	39	be	be	VB
cord-346853-0c1qdjb5	31	40	tracked	track	VBN
cord-346853-0c1qdjb5	31	41	more	more	RBR
cord-346853-0c1qdjb5	31	42	readily	readily	RB
cord-346853-0c1qdjb5	31	43	.	.	.
cord-346853-0c1qdjb5	32	1	To	to	TO
cord-346853-0c1qdjb5	32	2	focus	focus	VB
cord-346853-0c1qdjb5	32	3	our	-PRON-	PRP$
cord-346853-0c1qdjb5	32	4	paper	paper	NN
cord-346853-0c1qdjb5	32	5	,	,	,
cord-346853-0c1qdjb5	32	6	we	-PRON-	PRP
cord-346853-0c1qdjb5	32	7	will	will	MD
cord-346853-0c1qdjb5	32	8	consider	consider	VB
cord-346853-0c1qdjb5	32	9	four	four	CD
cord-346853-0c1qdjb5	32	10	key	key	JJ
cord-346853-0c1qdjb5	32	11	questions	question	NNS
cord-346853-0c1qdjb5	32	12	:	:	:
cord-346853-0c1qdjb5	32	13	1	1	CD
cord-346853-0c1qdjb5	32	14	.	.	.
cord-346853-0c1qdjb5	33	1	Are	be	VBP
cord-346853-0c1qdjb5	33	2	certain	certain	JJ
cord-346853-0c1qdjb5	33	3	types	type	NNS
cord-346853-0c1qdjb5	33	4	of	of	IN
cord-346853-0c1qdjb5	33	5	virus	virus	NN
cord-346853-0c1qdjb5	33	6	more	more	RBR
cord-346853-0c1qdjb5	33	7	likely	likely	JJ
cord-346853-0c1qdjb5	33	8	to	to	TO
cord-346853-0c1qdjb5	33	9	emerge	emerge	VB
cord-346853-0c1qdjb5	33	10	than	than	IN
cord-346853-0c1qdjb5	33	11	others	other	NNS
cord-346853-0c1qdjb5	33	12	?	?	.
cord-346853-0c1qdjb5	34	1	2	2	LS
cord-346853-0c1qdjb5	34	2	.	.	.
cord-346853-0c1qdjb5	35	1	Are	be	VBP
cord-346853-0c1qdjb5	35	2	viruses	virus	NNS
cord-346853-0c1qdjb5	35	3	from	from	IN
cord-346853-0c1qdjb5	35	4	phylogenetically	phylogenetically	RB
cord-346853-0c1qdjb5	35	5	related	relate	VBN
cord-346853-0c1qdjb5	35	6	host	host	NN
cord-346853-0c1qdjb5	35	7	species	specie	NNS
cord-346853-0c1qdjb5	35	8	more	more	RBR
cord-346853-0c1qdjb5	35	9	likely	likely	JJ
cord-346853-0c1qdjb5	35	10	to	to	TO
cord-346853-0c1qdjb5	35	11	undergo	undergo	VB
cord-346853-0c1qdjb5	35	12	cross	cross	JJ
cord-346853-0c1qdjb5	35	13	-	-	JJ
cord-346853-0c1qdjb5	35	14	species	species	JJ
cord-346853-0c1qdjb5	35	15	transmission	transmission	NN
cord-346853-0c1qdjb5	35	16	than	than	IN
cord-346853-0c1qdjb5	35	17	those	those	DT
cord-346853-0c1qdjb5	35	18	viruses	virus	NNS
cord-346853-0c1qdjb5	35	19	from	from	IN
cord-346853-0c1qdjb5	35	20	distantly	distantly	RB
cord-346853-0c1qdjb5	35	21	related	relate	VBN
cord-346853-0c1qdjb5	35	22	host	host	NN
cord-346853-0c1qdjb5	35	23	species	specie	NNS
cord-346853-0c1qdjb5	35	24	?	?	.
cord-346853-0c1qdjb5	36	1	3	3	LS
cord-346853-0c1qdjb5	36	2	.	.	.
cord-346853-0c1qdjb5	37	1	Does	do	VBZ
cord-346853-0c1qdjb5	37	2	viral	viral	JJ
cord-346853-0c1qdjb5	37	3	emergence	emergence	NN
cord-346853-0c1qdjb5	37	4	require	require	VB
cord-346853-0c1qdjb5	37	5	adaptation	adaptation	NN
cord-346853-0c1qdjb5	37	6	to	to	IN
cord-346853-0c1qdjb5	37	7	the	the	DT
cord-346853-0c1qdjb5	37	8	new	new	JJ
cord-346853-0c1qdjb5	37	9	host	host	NN
cord-346853-0c1qdjb5	37	10	species	specie	NNS
cord-346853-0c1qdjb5	37	11	?	?	.
cord-346853-0c1qdjb5	38	1	4	4	LS
cord-346853-0c1qdjb5	38	2	.	.	.
cord-346853-0c1qdjb5	39	1	Is	be	VBZ
cord-346853-0c1qdjb5	39	2	recombination	recombination	NN
cord-346853-0c1qdjb5	39	3	a	a	DT
cord-346853-0c1qdjb5	39	4	prerequisite	prerequisite	NN
cord-346853-0c1qdjb5	39	5	for	for	IN
cord-346853-0c1qdjb5	39	6	viral	viral	JJ
cord-346853-0c1qdjb5	39	7	emergence	emergence	NN
cord-346853-0c1qdjb5	39	8	?	?	.
cord-346853-0c1qdjb5	40	1	Although	although	IN
cord-346853-0c1qdjb5	40	2	definitive	definitive	JJ
cord-346853-0c1qdjb5	40	3	answers	answer	NNS
cord-346853-0c1qdjb5	40	4	will	will	MD
cord-346853-0c1qdjb5	40	5	not	not	RB
cord-346853-0c1qdjb5	40	6	be	be	VB
cord-346853-0c1qdjb5	40	7	forthcoming	forthcoming	JJ
cord-346853-0c1qdjb5	40	8	in	in	IN
cord-346853-0c1qdjb5	40	9	all	all	DT
cord-346853-0c1qdjb5	40	10	cases	case	NNS
cord-346853-0c1qdjb5	40	11	,	,	,
cord-346853-0c1qdjb5	40	12	we	-PRON-	PRP
cord-346853-0c1qdjb5	40	13	discuss	discuss	VBP
cord-346853-0c1qdjb5	40	14	the	the	DT
cord-346853-0c1qdjb5	40	15	data	datum	NNS
cord-346853-0c1qdjb5	40	16	required	require	VBN
cord-346853-0c1qdjb5	40	17	to	to	TO
cord-346853-0c1qdjb5	40	18	resolve	resolve	VB
cord-346853-0c1qdjb5	40	19	these	these	DT
cord-346853-0c1qdjb5	40	20	issues	issue	NNS
cord-346853-0c1qdjb5	40	21	.	.	.
cord-346853-0c1qdjb5	41	1	Finally	finally	RB
cord-346853-0c1qdjb5	41	2	,	,	,
cord-346853-0c1qdjb5	41	3	as	as	RB
cord-346853-0c1qdjb5	41	4	well	well	RB
cord-346853-0c1qdjb5	41	5	as	as	IN
cord-346853-0c1qdjb5	41	6	shedding	shed	VBG
cord-346853-0c1qdjb5	41	7	new	new	JJ
cord-346853-0c1qdjb5	41	8	light	light	NN
cord-346853-0c1qdjb5	41	9	on	on	IN
cord-346853-0c1qdjb5	41	10	the	the	DT
cord-346853-0c1qdjb5	41	11	process	process	NN
cord-346853-0c1qdjb5	41	12	of	of	IN
cord-346853-0c1qdjb5	41	13	emergence	emergence	NN
cord-346853-0c1qdjb5	41	14	in	in	IN
cord-346853-0c1qdjb5	41	15	particular	particular	JJ
cord-346853-0c1qdjb5	41	16	,	,	,
cord-346853-0c1qdjb5	41	17	answering	answer	VBG
cord-346853-0c1qdjb5	41	18	these	these	DT
cord-346853-0c1qdjb5	41	19	questions	question	NNS
cord-346853-0c1qdjb5	41	20	will	will	MD
cord-346853-0c1qdjb5	41	21	provide	provide	VB
cord-346853-0c1qdjb5	41	22	more	more	JJR
cord-346853-0c1qdjb5	41	23	general	general	JJ
cord-346853-0c1qdjb5	41	24	insights	insight	NNS
cord-346853-0c1qdjb5	41	25	into	into	IN
cord-346853-0c1qdjb5	41	26	the	the	DT
cord-346853-0c1qdjb5	41	27	nature	nature	NN
cord-346853-0c1qdjb5	41	28	of	of	IN
cord-346853-0c1qdjb5	41	29	viral	viral	JJ
cord-346853-0c1qdjb5	41	30	evolution	evolution	NN
cord-346853-0c1qdjb5	41	31	.	.	.
cord-346853-0c1qdjb5	42	1	The	the	DT
cord-346853-0c1qdjb5	42	2	broadest	broad	JJS
cord-346853-0c1qdjb5	42	3	division	division	NN
cord-346853-0c1qdjb5	42	4	in	in	IN
cord-346853-0c1qdjb5	42	5	virus	virus	NN
cord-346853-0c1qdjb5	42	6	classification	classification	NN
cord-346853-0c1qdjb5	42	7	is	be	VBZ
cord-346853-0c1qdjb5	42	8	between	between	IN
cord-346853-0c1qdjb5	42	9	those	those	DT
cord-346853-0c1qdjb5	42	10	viruses	virus	NNS
cord-346853-0c1qdjb5	42	11	in	in	IN
cord-346853-0c1qdjb5	42	12	which	which	WDT
cord-346853-0c1qdjb5	42	13	the	the	DT
cord-346853-0c1qdjb5	42	14	genome	genome	NN
cord-346853-0c1qdjb5	42	15	is	be	VBZ
cord-346853-0c1qdjb5	42	16	composed	compose	VBN
cord-346853-0c1qdjb5	42	17	of	of	IN
cord-346853-0c1qdjb5	42	18	DNA	dna	NN
cord-346853-0c1qdjb5	42	19	(	(	-LRB-
cord-346853-0c1qdjb5	42	20	DNA	dna	NN
cord-346853-0c1qdjb5	42	21	viruses	virus	NNS
cord-346853-0c1qdjb5	42	22	)	)	-RRB-
cord-346853-0c1qdjb5	42	23	and	and	CC
cord-346853-0c1qdjb5	42	24	those	those	DT
cord-346853-0c1qdjb5	42	25	where	where	WRB
cord-346853-0c1qdjb5	42	26	the	the	DT
cord-346853-0c1qdjb5	42	27	genomic	genomic	JJ
cord-346853-0c1qdjb5	42	28	nucleic	nucleic	JJ
cord-346853-0c1qdjb5	42	29	acid	acid	NN
cord-346853-0c1qdjb5	42	30	comprises	comprise	VBZ
cord-346853-0c1qdjb5	42	31	RNA	RNA	NNP
cord-346853-0c1qdjb5	42	32	(	(	-LRB-
cord-346853-0c1qdjb5	42	33	RNA	RNA	NNP
cord-346853-0c1qdjb5	42	34	viruses	virus	NNS
cord-346853-0c1qdjb5	42	35	)	)	-RRB-
cord-346853-0c1qdjb5	42	36	,	,	,
cord-346853-0c1qdjb5	42	37	with	with	IN
cord-346853-0c1qdjb5	42	38	the	the	DT
cord-346853-0c1qdjb5	42	39	latter	latter	JJ
cord-346853-0c1qdjb5	42	40	also	also	RB
cord-346853-0c1qdjb5	42	41	usually	usually	RB
cord-346853-0c1qdjb5	42	42	considered	consider	VBN
cord-346853-0c1qdjb5	42	43	to	to	TO
cord-346853-0c1qdjb5	42	44	include	include	VB
cord-346853-0c1qdjb5	42	45	retroviruses	retrovirus	NNS
cord-346853-0c1qdjb5	42	46	that	that	WDT
cord-346853-0c1qdjb5	42	47	make	make	VBP
cord-346853-0c1qdjb5	42	48	a	a	DT
cord-346853-0c1qdjb5	42	49	DNA	dna	NN
cord-346853-0c1qdjb5	42	50	copy	copy	NN
cord-346853-0c1qdjb5	42	51	of	of	IN
cord-346853-0c1qdjb5	42	52	the	the	DT
cord-346853-0c1qdjb5	42	53	RNA	RNA	NNP
cord-346853-0c1qdjb5	42	54	genome	genome	NN
cord-346853-0c1qdjb5	42	55	through	through	IN
cord-346853-0c1qdjb5	42	56	reverse	reverse	JJ
cord-346853-0c1qdjb5	42	57	transcription	transcription	NN
cord-346853-0c1qdjb5	42	58	.	.	.
cord-346853-0c1qdjb5	43	1	Although	although	IN
cord-346853-0c1qdjb5	43	2	most	most	RBS
cord-346853-0c1qdjb5	43	3	known	know	VBN
cord-346853-0c1qdjb5	43	4	viruses	virus	NNS
cord-346853-0c1qdjb5	43	5	have	have	VBP
cord-346853-0c1qdjb5	43	6	RNA	RNA	NNP
cord-346853-0c1qdjb5	43	7	genomes	genome	NNS
cord-346853-0c1qdjb5	43	8	,	,	,
cord-346853-0c1qdjb5	43	9	even	even	RB
cord-346853-0c1qdjb5	43	10	accounting	account	VBG
cord-346853-0c1qdjb5	43	11	for	for	IN
cord-346853-0c1qdjb5	43	12	this	this	DT
cord-346853-0c1qdjb5	43	13	bias	bias	NN
cord-346853-0c1qdjb5	43	14	it	-PRON-	PRP
cord-346853-0c1qdjb5	43	15	is	be	VBZ
cord-346853-0c1qdjb5	43	16	clear	clear	JJ
cord-346853-0c1qdjb5	43	17	that	that	IN
cord-346853-0c1qdjb5	43	18	RNA	RNA	NNP
cord-346853-0c1qdjb5	43	19	viruses	virus	NNS
cord-346853-0c1qdjb5	43	20	are	be	VBP
cord-346853-0c1qdjb5	43	21	more	more	RBR
cord-346853-0c1qdjb5	43	22	often	often	RB
cord-346853-0c1qdjb5	43	23	associated	associate	VBN
cord-346853-0c1qdjb5	43	24	with	with	IN
cord-346853-0c1qdjb5	43	25	emerging	emerge	VBG
cord-346853-0c1qdjb5	43	26	diseases	disease	NNS
cord-346853-0c1qdjb5	43	27	than	than	IN
cord-346853-0c1qdjb5	43	28	DNA	dna	NN
cord-346853-0c1qdjb5	43	29	viruses	virus	NNS
cord-346853-0c1qdjb5	44	1	(	(	-LRB-
cord-346853-0c1qdjb5	44	2	Cleaveland	Cleaveland	NNP
cord-346853-0c1qdjb5	44	3	et	et	NNP
cord-346853-0c1qdjb5	44	4	al	al	NNP
cord-346853-0c1qdjb5	44	5	.	.	.
cord-346853-0c1qdjb5	45	1	2001	2001	CD
cord-346853-0c1qdjb5	45	2	;	;	:
cord-346853-0c1qdjb5	45	3	Woolhouse	Woolhouse	NNP
cord-346853-0c1qdjb5	45	4	2002	2002	CD
cord-346853-0c1qdjb5	45	5	;	;	:
cord-346853-0c1qdjb5	45	6	see	see	VB
cord-346853-0c1qdjb5	45	7	the	the	DT
cord-346853-0c1qdjb5	45	8	chapter	chapter	NN
cord-346853-0c1qdjb5	45	9	by	by	IN
cord-346853-0c1qdjb5	45	10	Cleaveland	Cleaveland	NNP
cord-346853-0c1qdjb5	45	11	et	et	NNP
cord-346853-0c1qdjb5	45	12	al	al	NNP
cord-346853-0c1qdjb5	45	13	.	.	.
cord-346853-0c1qdjb5	46	1	,	,	,
cord-346853-0c1qdjb5	46	2	this	this	DT
cord-346853-0c1qdjb5	46	3	volume	volume	NN
cord-346853-0c1qdjb5	46	4	)	)	-RRB-
cord-346853-0c1qdjb5	46	5	.	.	.
cord-346853-0c1qdjb5	47	1	In	in	IN
cord-346853-0c1qdjb5	47	2	contrast	contrast	NN
cord-346853-0c1qdjb5	47	3	,	,	,
cord-346853-0c1qdjb5	47	4	DNA	dna	NN
cord-346853-0c1qdjb5	47	5	viruses	virus	NNS
cord-346853-0c1qdjb5	47	6	are	be	VBP
cord-346853-0c1qdjb5	47	7	often	often	RB
cord-346853-0c1qdjb5	47	8	associated	associate	VBN
cord-346853-0c1qdjb5	47	9	with	with	IN
cord-346853-0c1qdjb5	47	10	a	a	DT
cord-346853-0c1qdjb5	47	11	process	process	NN
cord-346853-0c1qdjb5	47	12	of	of	IN
cord-346853-0c1qdjb5	47	13	virus	virus	NN
cord-346853-0c1qdjb5	47	14	-	-	HYPH
cord-346853-0c1qdjb5	47	15	host	host	NN
cord-346853-0c1qdjb5	47	16	co	co	NN
cord-346853-0c1qdjb5	47	17	-	-	NN
cord-346853-0c1qdjb5	47	18	speciation	speciation	NN
cord-346853-0c1qdjb5	47	19	that	that	WDT
cord-346853-0c1qdjb5	47	20	can	can	MD
cord-346853-0c1qdjb5	47	21	extend	extend	VB
cord-346853-0c1qdjb5	47	22	many	many	JJ
cord-346853-0c1qdjb5	47	23	millions	million	NNS
cord-346853-0c1qdjb5	47	24	of	of	IN
cord-346853-0c1qdjb5	47	25	years	year	NNS
cord-346853-0c1qdjb5	47	26	.	.	.
cord-346853-0c1qdjb5	48	1	This	this	DT
cord-346853-0c1qdjb5	48	2	is	be	VBZ
cord-346853-0c1qdjb5	48	3	perhaps	perhaps	RB
cord-346853-0c1qdjb5	48	4	because	because	IN
cord-346853-0c1qdjb5	48	5	DNA	dna	NN
cord-346853-0c1qdjb5	48	6	viruses	virus	NNS
cord-346853-0c1qdjb5	48	7	more	more	RBR
cord-346853-0c1qdjb5	48	8	often	often	RB
cord-346853-0c1qdjb5	48	9	establish	establish	VBP
cord-346853-0c1qdjb5	48	10	persistent	persistent	JJ
cord-346853-0c1qdjb5	48	11	infections	infection	NNS
cord-346853-0c1qdjb5	48	12	than	than	IN
cord-346853-0c1qdjb5	48	13	RNA	RNA	NNP
cord-346853-0c1qdjb5	48	14	viruses	virus	NNS
cord-346853-0c1qdjb5	48	15	and	and	CC
cord-346853-0c1qdjb5	48	16	so	so	RB
cord-346853-0c1qdjb5	48	17	can	can	MD
cord-346853-0c1qdjb5	48	18	more	more	RBR
cord-346853-0c1qdjb5	48	19	easily	easily	RB
cord-346853-0c1qdjb5	48	20	track	track	VB
cord-346853-0c1qdjb5	48	21	host	host	NN
cord-346853-0c1qdjb5	48	22	evolution	evolution	NN
cord-346853-0c1qdjb5	48	23	(	(	-LRB-
cord-346853-0c1qdjb5	48	24	Holmes	Holmes	NNP
cord-346853-0c1qdjb5	48	25	2004	2004	CD
cord-346853-0c1qdjb5	48	26	)	)	-RRB-
cord-346853-0c1qdjb5	48	27	.	.	.
cord-346853-0c1qdjb5	49	1	That	that	IN
cord-346853-0c1qdjb5	49	2	RNA	RNA	NNP
cord-346853-0c1qdjb5	49	3	viruses	virus	NNS
cord-346853-0c1qdjb5	49	4	seem	seem	VBP
cord-346853-0c1qdjb5	49	5	to	to	TO
cord-346853-0c1qdjb5	49	6	possess	possess	VB
cord-346853-0c1qdjb5	49	7	inherently	inherently	RB
cord-346853-0c1qdjb5	49	8	more	more	JJR
cord-346853-0c1qdjb5	49	9	"	"	``
cord-346853-0c1qdjb5	49	10	emergibility	emergibility	NN
cord-346853-0c1qdjb5	49	11	"	"	''
cord-346853-0c1qdjb5	49	12	than	than	IN
cord-346853-0c1qdjb5	49	13	DNA	dna	NN
cord-346853-0c1qdjb5	49	14	viruses	virus	NNS
cord-346853-0c1qdjb5	49	15	has	have	VBZ
cord-346853-0c1qdjb5	49	16	usually	usually	RB
cord-346853-0c1qdjb5	49	17	been	be	VBN
cord-346853-0c1qdjb5	49	18	put	put	VBN
cord-346853-0c1qdjb5	49	19	down	down	RP
cord-346853-0c1qdjb5	49	20	to	to	IN
cord-346853-0c1qdjb5	49	21	their	-PRON-	PRP$
cord-346853-0c1qdjb5	49	22	very	very	RB
cord-346853-0c1qdjb5	49	23	rapid	rapid	JJ
cord-346853-0c1qdjb5	49	24	rates	rate	NNS
cord-346853-0c1qdjb5	49	25	of	of	IN
cord-346853-0c1qdjb5	49	26	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	49	27	change	change	NN
cord-346853-0c1qdjb5	49	28	.	.	.
cord-346853-0c1qdjb5	50	1	RNA	RNA	NNP
cord-346853-0c1qdjb5	50	2	viruses	virus	NNS
cord-346853-0c1qdjb5	50	3	are	be	VBP
cord-346853-0c1qdjb5	50	4	thought	think	VBN
cord-346853-0c1qdjb5	50	5	to	to	TO
cord-346853-0c1qdjb5	50	6	evolve	evolve	VB
cord-346853-0c1qdjb5	50	7	many	many	JJ
cord-346853-0c1qdjb5	50	8	logs	log	NNS
cord-346853-0c1qdjb5	50	9	faster	fast	RBR
cord-346853-0c1qdjb5	50	10	than	than	IN
cord-346853-0c1qdjb5	50	11	DNA	dna	NN
cord-346853-0c1qdjb5	50	12	viruses	virus	NNS
cord-346853-0c1qdjb5	50	13	because	because	IN
cord-346853-0c1qdjb5	50	14	of	of	IN
cord-346853-0c1qdjb5	50	15	a	a	DT
cord-346853-0c1qdjb5	50	16	combination	combination	NN
cord-346853-0c1qdjb5	50	17	of	of	IN
cord-346853-0c1qdjb5	50	18	highly	highly	RB
cord-346853-0c1qdjb5	50	19	error	error	NN
cord-346853-0c1qdjb5	50	20	-	-	HYPH
cord-346853-0c1qdjb5	50	21	prone	prone	JJ
cord-346853-0c1qdjb5	50	22	replication	replication	NN
cord-346853-0c1qdjb5	50	23	with	with	IN
cord-346853-0c1qdjb5	50	24	RNA	rna	NN
cord-346853-0c1qdjb5	50	25	polymerase	polymerase	NN
cord-346853-0c1qdjb5	50	26	or	or	CC
cord-346853-0c1qdjb5	50	27	reverse	reverse	JJ
cord-346853-0c1qdjb5	50	28	transcriptase	transcriptase	NN
cord-346853-0c1qdjb5	50	29	,	,	,
cord-346853-0c1qdjb5	50	30	large	large	JJ
cord-346853-0c1qdjb5	50	31	population	population	NN
cord-346853-0c1qdjb5	50	32	sizes	size	NNS
cord-346853-0c1qdjb5	50	33	,	,	,
cord-346853-0c1qdjb5	50	34	and	and	CC
cord-346853-0c1qdjb5	50	35	rapid	rapid	JJ
cord-346853-0c1qdjb5	50	36	replication	replication	NN
cord-346853-0c1qdjb5	50	37	rates	rate	NNS
cord-346853-0c1qdjb5	50	38	(	(	-LRB-
cord-346853-0c1qdjb5	50	39	Domingo	Domingo	NNP
cord-346853-0c1qdjb5	50	40	and	and	CC
cord-346853-0c1qdjb5	50	41	Holland	Holland	NNP
cord-346853-0c1qdjb5	50	42	1997	1997	CD
cord-346853-0c1qdjb5	50	43	;	;	:
cord-346853-0c1qdjb5	50	44	Moya	Moya	NNP
cord-346853-0c1qdjb5	50	45	et	et	NNP
cord-346853-0c1qdjb5	50	46	al	al	NNP
cord-346853-0c1qdjb5	50	47	.	.	.
cord-346853-0c1qdjb5	50	48	2004	2004	CD
cord-346853-0c1qdjb5	50	49	)	)	-RRB-
cord-346853-0c1qdjb5	50	50	.	.	.
cord-346853-0c1qdjb5	51	1	In	in	IN
cord-346853-0c1qdjb5	51	2	turn	turn	NN
cord-346853-0c1qdjb5	51	3	,	,	,
cord-346853-0c1qdjb5	51	4	a	a	DT
cord-346853-0c1qdjb5	51	5	rapid	rapid	JJ
cord-346853-0c1qdjb5	51	6	rate	rate	NN
cord-346853-0c1qdjb5	51	7	of	of	IN
cord-346853-0c1qdjb5	51	8	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	51	9	change	change	NN
cord-346853-0c1qdjb5	51	10	allows	allow	VBZ
cord-346853-0c1qdjb5	51	11	RNA	RNA	NNP
cord-346853-0c1qdjb5	51	12	viruses	virus	NNS
cord-346853-0c1qdjb5	51	13	to	to	TO
cord-346853-0c1qdjb5	51	14	quickly	quickly	RB
cord-346853-0c1qdjb5	51	15	generate	generate	VB
cord-346853-0c1qdjb5	51	16	the	the	DT
cord-346853-0c1qdjb5	51	17	mutations	mutation	NNS
cord-346853-0c1qdjb5	51	18	that	that	WDT
cord-346853-0c1qdjb5	51	19	might	may	MD
cord-346853-0c1qdjb5	51	20	be	be	VB
cord-346853-0c1qdjb5	51	21	required	require	VBN
cord-346853-0c1qdjb5	51	22	to	to	TO
cord-346853-0c1qdjb5	51	23	adapt	adapt	VB
cord-346853-0c1qdjb5	51	24	them	-PRON-	PRP
cord-346853-0c1qdjb5	51	25	to	to	IN
cord-346853-0c1qdjb5	51	26	new	new	JJ
cord-346853-0c1qdjb5	51	27	environments	environment	NNS
cord-346853-0c1qdjb5	51	28	,	,	,
cord-346853-0c1qdjb5	51	29	including	include	VBG
cord-346853-0c1qdjb5	51	30	new	new	JJ
cord-346853-0c1qdjb5	51	31	host	host	NN
cord-346853-0c1qdjb5	51	32	species	specie	NNS
cord-346853-0c1qdjb5	51	33	.	.	.
cord-346853-0c1qdjb5	52	1	Although	although	IN
cord-346853-0c1qdjb5	52	2	this	this	DT
cord-346853-0c1qdjb5	52	3	effect	effect	NN
cord-346853-0c1qdjb5	52	4	is	be	VBZ
cord-346853-0c1qdjb5	52	5	broadly	broadly	RB
cord-346853-0c1qdjb5	52	6	true	true	JJ
cord-346853-0c1qdjb5	52	7	,	,	,
cord-346853-0c1qdjb5	52	8	there	there	EX
cord-346853-0c1qdjb5	52	9	is	be	VBZ
cord-346853-0c1qdjb5	52	10	still	still	RB
cord-346853-0c1qdjb5	52	11	substantial	substantial	JJ
cord-346853-0c1qdjb5	52	12	variation	variation	NN
cord-346853-0c1qdjb5	52	13	among	among	IN
cord-346853-0c1qdjb5	52	14	RNA	RNA	NNP
cord-346853-0c1qdjb5	52	15	viruses	virus	NNS
cord-346853-0c1qdjb5	52	16	in	in	IN
cord-346853-0c1qdjb5	52	17	their	-PRON-	PRP$
cord-346853-0c1qdjb5	52	18	ability	ability	NN
cord-346853-0c1qdjb5	52	19	to	to	TO
cord-346853-0c1qdjb5	52	20	cause	cause	VB
cord-346853-0c1qdjb5	52	21	emergent	emergent	JJ
cord-346853-0c1qdjb5	52	22	diseases	disease	NNS
cord-346853-0c1qdjb5	52	23	.	.	.
cord-346853-0c1qdjb5	53	1	Understanding	understand	VBG
cord-346853-0c1qdjb5	53	2	the	the	DT
cord-346853-0c1qdjb5	53	3	basis	basis	NN
cord-346853-0c1qdjb5	53	4	of	of	IN
cord-346853-0c1qdjb5	53	5	this	this	DT
cord-346853-0c1qdjb5	53	6	variation	variation	NN
cord-346853-0c1qdjb5	53	7	is	be	VBZ
cord-346853-0c1qdjb5	53	8	critical	critical	JJ
cord-346853-0c1qdjb5	53	9	to	to	IN
cord-346853-0c1qdjb5	53	10	the	the	DT
cord-346853-0c1qdjb5	53	11	development	development	NN
cord-346853-0c1qdjb5	53	12	of	of	IN
cord-346853-0c1qdjb5	53	13	an	an	DT
cord-346853-0c1qdjb5	53	14	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	53	15	model	model	NN
cord-346853-0c1qdjb5	53	16	of	of	IN
cord-346853-0c1qdjb5	53	17	viral	viral	JJ
cord-346853-0c1qdjb5	53	18	emergence	emergence	NN
cord-346853-0c1qdjb5	53	19	and	and	CC
cord-346853-0c1qdjb5	53	20	for	for	IN
cord-346853-0c1qdjb5	53	21	understanding	understand	VBG
cord-346853-0c1qdjb5	53	22	the	the	DT
cord-346853-0c1qdjb5	53	23	constraints	constraint	NNS
cord-346853-0c1qdjb5	53	24	on	on	IN
cord-346853-0c1qdjb5	53	25	RNA	RNA	NNP
cord-346853-0c1qdjb5	53	26	virus	virus	NN
cord-346853-0c1qdjb5	53	27	evolution	evolution	NN
cord-346853-0c1qdjb5	53	28	in	in	IN
cord-346853-0c1qdjb5	53	29	general	general	JJ
cord-346853-0c1qdjb5	53	30	.	.	.
cord-346853-0c1qdjb5	54	1	If	if	IN
cord-346853-0c1qdjb5	54	2	the	the	DT
cord-346853-0c1qdjb5	54	3	rate	rate	NN
cord-346853-0c1qdjb5	54	4	of	of	IN
cord-346853-0c1qdjb5	54	5	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	54	6	change	change	NN
cord-346853-0c1qdjb5	54	7	is	be	VBZ
cord-346853-0c1qdjb5	54	8	driven	drive	VBN
cord-346853-0c1qdjb5	54	9	by	by	IN
cord-346853-0c1qdjb5	54	10	the	the	DT
cord-346853-0c1qdjb5	54	11	rate	rate	NN
cord-346853-0c1qdjb5	54	12	at	at	IN
cord-346853-0c1qdjb5	54	13	which	which	WDT
cord-346853-0c1qdjb5	54	14	neutral	neutral	JJ
cord-346853-0c1qdjb5	54	15	variants	variant	NNS
cord-346853-0c1qdjb5	54	16	are	be	VBP
cord-346853-0c1qdjb5	54	17	generated	generate	VBN
cord-346853-0c1qdjb5	54	18	,	,	,
cord-346853-0c1qdjb5	54	19	then	then	RB
cord-346853-0c1qdjb5	54	20	the	the	DT
cord-346853-0c1qdjb5	54	21	most	most	RBS
cord-346853-0c1qdjb5	54	22	important	important	JJ
cord-346853-0c1qdjb5	54	23	factors	factor	NNS
cord-346853-0c1qdjb5	54	24	determining	determine	VBG
cord-346853-0c1qdjb5	54	25	rates	rate	NNS
cord-346853-0c1qdjb5	54	26	of	of	IN
cord-346853-0c1qdjb5	54	27	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	54	28	change	change	NN
cord-346853-0c1qdjb5	54	29	are	be	VBP
cord-346853-0c1qdjb5	54	30	the	the	DT
cord-346853-0c1qdjb5	54	31	replication	replication	NN
cord-346853-0c1qdjb5	54	32	error	error	NN
cord-346853-0c1qdjb5	54	33	rate	rate	NN
cord-346853-0c1qdjb5	54	34	and	and	CC
cord-346853-0c1qdjb5	54	35	the	the	DT
cord-346853-0c1qdjb5	54	36	generation	generation	NN
cord-346853-0c1qdjb5	54	37	time	time	NN
cord-346853-0c1qdjb5	54	38	.	.	.
cord-346853-0c1qdjb5	55	1	The	the	DT
cord-346853-0c1qdjb5	55	2	variation	variation	NN
cord-346853-0c1qdjb5	55	3	in	in	IN
cord-346853-0c1qdjb5	55	4	error	error	NN
cord-346853-0c1qdjb5	55	5	rates	rate	NNS
cord-346853-0c1qdjb5	55	6	among	among	IN
cord-346853-0c1qdjb5	55	7	viruses	virus	NNS
cord-346853-0c1qdjb5	55	8	is	be	VBZ
cord-346853-0c1qdjb5	55	9	a	a	DT
cord-346853-0c1qdjb5	55	10	subject	subject	NN
cord-346853-0c1qdjb5	55	11	of	of	IN
cord-346853-0c1qdjb5	55	12	considerable	considerable	JJ
cord-346853-0c1qdjb5	55	13	research	research	NN
cord-346853-0c1qdjb5	55	14	activity	activity	NN
cord-346853-0c1qdjb5	55	15	(	(	-LRB-
cord-346853-0c1qdjb5	55	16	Malpica	Malpica	NNP
cord-346853-0c1qdjb5	55	17	et	et	NNP
cord-346853-0c1qdjb5	55	18	al	al	NNP
cord-346853-0c1qdjb5	55	19	.	.	.
cord-346853-0c1qdjb5	55	20	2002	2002	CD
cord-346853-0c1qdjb5	56	1	;	;	:
cord-346853-0c1qdjb5	56	2	Pugachev	Pugachev	NNP
cord-346853-0c1qdjb5	56	3	et	et	NNP
cord-346853-0c1qdjb5	56	4	al	al	NNP
cord-346853-0c1qdjb5	56	5	.	.	.
cord-346853-0c1qdjb5	56	6	2004	2004	CD
cord-346853-0c1qdjb5	56	7	)	)	-RRB-
cord-346853-0c1qdjb5	56	8	and	and	CC
cord-346853-0c1qdjb5	57	1	there	there	EX
cord-346853-0c1qdjb5	57	2	is	be	VBZ
cord-346853-0c1qdjb5	57	3	a	a	DT
cord-346853-0c1qdjb5	57	4	growing	grow	VBG
cord-346853-0c1qdjb5	57	5	body	body	NN
cord-346853-0c1qdjb5	57	6	of	of	IN
cord-346853-0c1qdjb5	57	7	data	datum	NNS
cord-346853-0c1qdjb5	57	8	on	on	IN
cord-346853-0c1qdjb5	57	9	how	how	WRB
cord-346853-0c1qdjb5	57	10	generation	generation	NN
cord-346853-0c1qdjb5	57	11	times	time	NNS
cord-346853-0c1qdjb5	57	12	vary	vary	VBP
cord-346853-0c1qdjb5	57	13	within	within	IN
cord-346853-0c1qdjb5	57	14	and	and	CC
cord-346853-0c1qdjb5	57	15	among	among	IN
cord-346853-0c1qdjb5	57	16	viruses	virus	NNS
cord-346853-0c1qdjb5	58	1	(	(	-LRB-
cord-346853-0c1qdjb5	58	2	Markowitz	Markowitz	NNP
cord-346853-0c1qdjb5	58	3	et	et	NNP
cord-346853-0c1qdjb5	58	4	al	al	NNP
cord-346853-0c1qdjb5	58	5	.	.	.
cord-346853-0c1qdjb5	59	1	2003	2003	CD
cord-346853-0c1qdjb5	59	2	;	;	:
cord-346853-0c1qdjb5	59	3	Whalley	Whalley	NNP
cord-346853-0c1qdjb5	59	4	et	et	NNP
cord-346853-0c1qdjb5	59	5	al	al	NNP
cord-346853-0c1qdjb5	59	6	.	.	NNP
cord-346853-0c1qdjb5	59	7	2001	2001	CD
cord-346853-0c1qdjb5	59	8	)	)	-RRB-
cord-346853-0c1qdjb5	59	9	.	.	.
cord-346853-0c1qdjb5	60	1	However	however	RB
cord-346853-0c1qdjb5	60	2	,	,	,
cord-346853-0c1qdjb5	60	3	despite	despite	IN
cord-346853-0c1qdjb5	60	4	a	a	DT
cord-346853-0c1qdjb5	60	5	wealth	wealth	NN
cord-346853-0c1qdjb5	60	6	of	of	IN
cord-346853-0c1qdjb5	60	7	population	population	NN
cord-346853-0c1qdjb5	60	8	genetic	genetic	JJ
cord-346853-0c1qdjb5	60	9	theory	theory	NN
cord-346853-0c1qdjb5	60	10	about	about	IN
cord-346853-0c1qdjb5	60	11	the	the	DT
cord-346853-0c1qdjb5	60	12	interplay	interplay	NN
cord-346853-0c1qdjb5	60	13	between	between	IN
cord-346853-0c1qdjb5	60	14	these	these	DT
cord-346853-0c1qdjb5	60	15	factors	factor	NNS
cord-346853-0c1qdjb5	60	16	and	and	CC
cord-346853-0c1qdjb5	60	17	natural	natural	JJ
cord-346853-0c1qdjb5	60	18	selection	selection	NN
cord-346853-0c1qdjb5	60	19	,	,	,
cord-346853-0c1qdjb5	60	20	we	-PRON-	PRP
cord-346853-0c1qdjb5	60	21	are	be	VBP
cord-346853-0c1qdjb5	60	22	still	still	RB
cord-346853-0c1qdjb5	60	23	some	some	DT
cord-346853-0c1qdjb5	60	24	way	way	NN
cord-346853-0c1qdjb5	60	25	from	from	IN
cord-346853-0c1qdjb5	60	26	producing	produce	VBG
cord-346853-0c1qdjb5	60	27	an	an	DT
cord-346853-0c1qdjb5	60	28	all	all	RB
cord-346853-0c1qdjb5	60	29	-	-	HYPH
cord-346853-0c1qdjb5	60	30	encompassing	encompass	VBG
cord-346853-0c1qdjb5	60	31	picture	picture	NN
cord-346853-0c1qdjb5	60	32	of	of	IN
cord-346853-0c1qdjb5	60	33	what	what	WP
cord-346853-0c1qdjb5	60	34	determines	determine	VBZ
cord-346853-0c1qdjb5	60	35	rates	rate	NNS
cord-346853-0c1qdjb5	60	36	of	of	IN
cord-346853-0c1qdjb5	60	37	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	60	38	change	change	NN
cord-346853-0c1qdjb5	60	39	in	in	IN
cord-346853-0c1qdjb5	60	40	viruses	virus	NNS
cord-346853-0c1qdjb5	60	41	.	.	.
cord-346853-0c1qdjb5	61	1	This	this	DT
cord-346853-0c1qdjb5	61	2	is	be	VBZ
cord-346853-0c1qdjb5	61	3	in	in	IN
cord-346853-0c1qdjb5	61	4	part	part	NN
cord-346853-0c1qdjb5	61	5	due	due	IN
cord-346853-0c1qdjb5	61	6	to	to	IN
cord-346853-0c1qdjb5	61	7	a	a	DT
cord-346853-0c1qdjb5	61	8	lack	lack	NN
cord-346853-0c1qdjb5	61	9	of	of	IN
cord-346853-0c1qdjb5	61	10	detailed	detailed	JJ
cord-346853-0c1qdjb5	61	11	and	and	CC
cord-346853-0c1qdjb5	61	12	comprehensive	comprehensive	JJ
cord-346853-0c1qdjb5	61	13	experimental	experimental	JJ
cord-346853-0c1qdjb5	61	14	measurements	measurement	NNS
cord-346853-0c1qdjb5	61	15	of	of	IN
cord-346853-0c1qdjb5	61	16	the	the	DT
cord-346853-0c1qdjb5	61	17	critical	critical	JJ
cord-346853-0c1qdjb5	61	18	parameters	parameter	NNS
cord-346853-0c1qdjb5	61	19	and	and	CC
cord-346853-0c1qdjb5	61	20	partly	partly	RB
cord-346853-0c1qdjb5	61	21	because	because	IN
cord-346853-0c1qdjb5	61	22	of	of	IN
cord-346853-0c1qdjb5	61	23	the	the	DT
cord-346853-0c1qdjb5	61	24	limited	limited	JJ
cord-346853-0c1qdjb5	61	25	complexity	complexity	NN
cord-346853-0c1qdjb5	61	26	of	of	IN
cord-346853-0c1qdjb5	61	27	available	available	JJ
cord-346853-0c1qdjb5	61	28	analytical	analytical	JJ
cord-346853-0c1qdjb5	61	29	models	model	NNS
cord-346853-0c1qdjb5	61	30	when	when	WRB
cord-346853-0c1qdjb5	61	31	compared	compare	VBN
cord-346853-0c1qdjb5	61	32	to	to	IN
cord-346853-0c1qdjb5	61	33	the	the	DT
cord-346853-0c1qdjb5	61	34	reality	reality	NN
cord-346853-0c1qdjb5	61	35	of	of	IN
cord-346853-0c1qdjb5	61	36	viral	viral	JJ
cord-346853-0c1qdjb5	61	37	evolution	evolution	NN
cord-346853-0c1qdjb5	61	38	.	.	.
cord-346853-0c1qdjb5	62	1	Moreover	moreover	RB
cord-346853-0c1qdjb5	62	2	,	,	,
cord-346853-0c1qdjb5	62	3	not	not	RB
cord-346853-0c1qdjb5	62	4	all	all	DT
cord-346853-0c1qdjb5	62	5	RNA	RNA	NNP
cord-346853-0c1qdjb5	62	6	and	and	CC
cord-346853-0c1qdjb5	62	7	DNA	dna	NN
cord-346853-0c1qdjb5	62	8	viruses	virus	NNS
cord-346853-0c1qdjb5	62	9	neatly	neatly	RB
cord-346853-0c1qdjb5	62	10	fit	fit	VBP
cord-346853-0c1qdjb5	62	11	the	the	DT
cord-346853-0c1qdjb5	62	12	picture	picture	NN
cord-346853-0c1qdjb5	62	13	of	of	IN
cord-346853-0c1qdjb5	62	14	rapid	rapid	JJ
cord-346853-0c1qdjb5	62	15	and	and	CC
cord-346853-0c1qdjb5	62	16	slow	slow	JJ
cord-346853-0c1qdjb5	62	17	evolution	evolution	NN
cord-346853-0c1qdjb5	62	18	,	,	,
cord-346853-0c1qdjb5	62	19	respectively	respectively	RB
cord-346853-0c1qdjb5	62	20	.	.	.
cord-346853-0c1qdjb5	63	1	The	the	DT
cord-346853-0c1qdjb5	63	2	most	most	RBS
cord-346853-0c1qdjb5	63	3	dramatic	dramatic	JJ
cord-346853-0c1qdjb5	63	4	example	example	NN
cord-346853-0c1qdjb5	63	5	is	be	VBZ
cord-346853-0c1qdjb5	63	6	that	that	DT
cord-346853-0c1qdjb5	63	7	of	of	IN
cord-346853-0c1qdjb5	63	8	simian	simian	JJ
cord-346853-0c1qdjb5	63	9	foamy	foamy	NN
cord-346853-0c1qdjb5	63	10	virus	virus	NN
cord-346853-0c1qdjb5	63	11	(	(	-LRB-
cord-346853-0c1qdjb5	63	12	SFV	SFV	NNP
cord-346853-0c1qdjb5	63	13	)	)	-RRB-
cord-346853-0c1qdjb5	63	14	,	,	,
cord-346853-0c1qdjb5	63	15	which	which	WDT
cord-346853-0c1qdjb5	63	16	has	have	VBZ
cord-346853-0c1qdjb5	63	17	co	co	VBN
cord-346853-0c1qdjb5	63	18	-	-	VBN
cord-346853-0c1qdjb5	63	19	diverged	diverged	JJ
cord-346853-0c1qdjb5	63	20	with	with	IN
cord-346853-0c1qdjb5	63	21	its	-PRON-	PRP$
cord-346853-0c1qdjb5	63	22	primate	primate	JJ
cord-346853-0c1qdjb5	63	23	hosts	host	NNS
cord-346853-0c1qdjb5	63	24	over	over	IN
cord-346853-0c1qdjb5	63	25	many	many	JJ
cord-346853-0c1qdjb5	63	26	million	million	CD
cord-346853-0c1qdjb5	63	27	of	of	IN
cord-346853-0c1qdjb5	63	28	years	year	NNS
cord-346853-0c1qdjb5	63	29	and	and	CC
cord-346853-0c1qdjb5	63	30	evolved	evolve	VBD
cord-346853-0c1qdjb5	63	31	at	at	IN
cord-346853-0c1qdjb5	63	32	the	the	DT
cord-346853-0c1qdjb5	63	33	remarkably	remarkably	RB
cord-346853-0c1qdjb5	63	34	low	low	JJ
cord-346853-0c1qdjb5	63	35	rate	rate	NN
cord-346853-0c1qdjb5	63	36	of	of	IN
cord-346853-0c1qdjb5	63	37	approximately	approximately	RB
cord-346853-0c1qdjb5	63	38	10	10	CD
cord-346853-0c1qdjb5	63	39	-8	-8	JJ
cord-346853-0c1qdjb5	63	40	substitutions	substitution	NNS
cord-346853-0c1qdjb5	63	41	per	per	IN
cord-346853-0c1qdjb5	63	42	site	site	NN
cord-346853-0c1qdjb5	63	43	,	,	,
cord-346853-0c1qdjb5	63	44	per	per	IN
cord-346853-0c1qdjb5	63	45	year	year	NN
cord-346853-0c1qdjb5	63	46	,	,	,
cord-346853-0c1qdjb5	63	47	similar	similar	JJ
cord-346853-0c1qdjb5	63	48	to	to	IN
cord-346853-0c1qdjb5	63	49	that	that	DT
cord-346853-0c1qdjb5	63	50	seen	see	VBN
cord-346853-0c1qdjb5	63	51	in	in	IN
cord-346853-0c1qdjb5	63	52	that	that	DT
cord-346853-0c1qdjb5	63	53	in	in	IN
cord-346853-0c1qdjb5	63	54	host	host	NN
cord-346853-0c1qdjb5	63	55	mitochondrial	mitochondrial	NN
cord-346853-0c1qdjb5	63	56	DNA	dna	NN
cord-346853-0c1qdjb5	63	57	(	(	-LRB-
cord-346853-0c1qdjb5	63	58	Switzer	Switzer	NNP
cord-346853-0c1qdjb5	63	59	et	et	NNP
cord-346853-0c1qdjb5	63	60	al	al	NNP
cord-346853-0c1qdjb5	63	61	.	.	NNP
cord-346853-0c1qdjb5	63	62	2005	2005	CD
cord-346853-0c1qdjb5	63	63	)	)	-RRB-
cord-346853-0c1qdjb5	63	64	.	.	.
cord-346853-0c1qdjb5	64	1	The	the	DT
cord-346853-0c1qdjb5	64	2	most	most	RBS
cord-346853-0c1qdjb5	64	3	likely	likely	JJ
cord-346853-0c1qdjb5	64	4	explanation	explanation	NN
cord-346853-0c1qdjb5	64	5	for	for	IN
cord-346853-0c1qdjb5	64	6	this	this	DT
cord-346853-0c1qdjb5	64	7	low	low	JJ
cord-346853-0c1qdjb5	64	8	rate	rate	NN
cord-346853-0c1qdjb5	64	9	of	of	IN
cord-346853-0c1qdjb5	64	10	change	change	NN
cord-346853-0c1qdjb5	64	11	is	be	VBZ
cord-346853-0c1qdjb5	64	12	a	a	DT
cord-346853-0c1qdjb5	64	13	combination	combination	NN
cord-346853-0c1qdjb5	64	14	of	of	IN
cord-346853-0c1qdjb5	64	15	greatly	greatly	RB
cord-346853-0c1qdjb5	64	16	reduced	reduce	VBN
cord-346853-0c1qdjb5	64	17	rates	rate	NNS
cord-346853-0c1qdjb5	64	18	of	of	IN
cord-346853-0c1qdjb5	64	19	replication	replication	NN
cord-346853-0c1qdjb5	64	20	and	and	CC
cord-346853-0c1qdjb5	64	21	strong	strong	JJ
cord-346853-0c1qdjb5	64	22	purifying	purifying	NN
cord-346853-0c1qdjb5	64	23	selection	selection	NN
cord-346853-0c1qdjb5	64	24	,	,	,
cord-346853-0c1qdjb5	64	25	so	so	IN
cord-346853-0c1qdjb5	64	26	that	that	IN
cord-346853-0c1qdjb5	64	27	the	the	DT
cord-346853-0c1qdjb5	64	28	vast	vast	JJ
cord-346853-0c1qdjb5	64	29	majority	majority	NN
cord-346853-0c1qdjb5	64	30	of	of	IN
cord-346853-0c1qdjb5	64	31	mutations	mutation	NNS
cord-346853-0c1qdjb5	64	32	that	that	WDT
cord-346853-0c1qdjb5	64	33	arise	arise	VBP
cord-346853-0c1qdjb5	64	34	are	be	VBP
cord-346853-0c1qdjb5	64	35	deleterious	deleterious	JJ
cord-346853-0c1qdjb5	64	36	and	and	CC
cord-346853-0c1qdjb5	64	37	selectively	selectively	RB
cord-346853-0c1qdjb5	64	38	eliminated	eliminate	VBN
cord-346853-0c1qdjb5	64	39	.	.	.
cord-346853-0c1qdjb5	65	1	At	at	IN
cord-346853-0c1qdjb5	65	2	the	the	DT
cord-346853-0c1qdjb5	65	3	other	other	JJ
cord-346853-0c1qdjb5	65	4	end	end	NN
cord-346853-0c1qdjb5	65	5	of	of	IN
cord-346853-0c1qdjb5	65	6	the	the	DT
cord-346853-0c1qdjb5	65	7	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	65	8	spectrum	spectrum	NN
cord-346853-0c1qdjb5	65	9	,	,	,
cord-346853-0c1qdjb5	65	10	there	there	EX
cord-346853-0c1qdjb5	65	11	is	be	VBZ
cord-346853-0c1qdjb5	65	12	growing	grow	VBG
cord-346853-0c1qdjb5	65	13	evidence	evidence	NN
cord-346853-0c1qdjb5	65	14	that	that	IN
cord-346853-0c1qdjb5	65	15	single	single	RB
cord-346853-0c1qdjb5	65	16	-	-	HYPH
cord-346853-0c1qdjb5	65	17	stranded	stranded	JJ
cord-346853-0c1qdjb5	65	18	(	(	-LRB-
cord-346853-0c1qdjb5	65	19	ss	ss	NNP
cord-346853-0c1qdjb5	65	20	)	)	-RRB-
cord-346853-0c1qdjb5	65	21	DNA	dna	NN
cord-346853-0c1qdjb5	65	22	viruses	virus	NNS
cord-346853-0c1qdjb5	65	23	evolve	evolve	VBP
cord-346853-0c1qdjb5	65	24	at	at	IN
cord-346853-0c1qdjb5	65	25	rates	rate	NNS
cord-346853-0c1qdjb5	65	26	approaching	approach	VBG
cord-346853-0c1qdjb5	65	27	those	those	DT
cord-346853-0c1qdjb5	65	28	seen	see	VBN
cord-346853-0c1qdjb5	65	29	in	in	IN
cord-346853-0c1qdjb5	65	30	RNA	RNA	NNP
cord-346853-0c1qdjb5	65	31	viruses	virus	NNS
cord-346853-0c1qdjb5	65	32	,	,	,
cord-346853-0c1qdjb5	65	33	most	most	RBS
cord-346853-0c1qdjb5	65	34	likely	likely	JJ
cord-346853-0c1qdjb5	65	35	because	because	IN
cord-346853-0c1qdjb5	65	36	of	of	IN
cord-346853-0c1qdjb5	65	37	high	high	JJ
cord-346853-0c1qdjb5	65	38	intrinsic	intrinsic	JJ
cord-346853-0c1qdjb5	65	39	error	error	NN
cord-346853-0c1qdjb5	65	40	rates	rate	NNS
cord-346853-0c1qdjb5	65	41	(	(	-LRB-
cord-346853-0c1qdjb5	65	42	Sanz	Sanz	NNP
cord-346853-0c1qdjb5	65	43	et	et	NNP
cord-346853-0c1qdjb5	65	44	al	al	NNP
cord-346853-0c1qdjb5	65	45	.	.	.
cord-346853-0c1qdjb5	65	46	1999	1999	CD
cord-346853-0c1qdjb5	65	47	;	;	:
cord-346853-0c1qdjb5	65	48	Shackleton	Shackleton	NNP
cord-346853-0c1qdjb5	65	49	et	et	NNP
cord-346853-0c1qdjb5	65	50	al	al	NNP
cord-346853-0c1qdjb5	65	51	.	.	NNP
cord-346853-0c1qdjb5	65	52	2005	2005	CD
cord-346853-0c1qdjb5	65	53	)	)	-RRB-
cord-346853-0c1qdjb5	65	54	.	.	.
cord-346853-0c1qdjb5	66	1	Although	although	IN
cord-346853-0c1qdjb5	66	2	mutation	mutation	NN
cord-346853-0c1qdjb5	66	3	provides	provide	VBZ
cord-346853-0c1qdjb5	66	4	the	the	DT
cord-346853-0c1qdjb5	66	5	raw	raw	JJ
cord-346853-0c1qdjb5	66	6	materials	material	NNS
cord-346853-0c1qdjb5	66	7	for	for	IN
cord-346853-0c1qdjb5	66	8	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	66	9	change	change	NN
cord-346853-0c1qdjb5	66	10	,	,	,
cord-346853-0c1qdjb5	66	11	it	-PRON-	PRP
cord-346853-0c1qdjb5	66	12	is	be	VBZ
cord-346853-0c1qdjb5	66	13	the	the	DT
cord-346853-0c1qdjb5	66	14	dual	dual	JJ
cord-346853-0c1qdjb5	66	15	processes	process	NNS
cord-346853-0c1qdjb5	66	16	of	of	IN
cord-346853-0c1qdjb5	66	17	genetic	genetic	JJ
cord-346853-0c1qdjb5	66	18	drift	drift	NN
cord-346853-0c1qdjb5	66	19	and	and	CC
cord-346853-0c1qdjb5	66	20	natural	natural	JJ
cord-346853-0c1qdjb5	66	21	selection	selection	NN
cord-346853-0c1qdjb5	66	22	that	that	WDT
cord-346853-0c1qdjb5	66	23	are	be	VBP
cord-346853-0c1qdjb5	66	24	the	the	DT
cord-346853-0c1qdjb5	66	25	ultimate	ultimate	JJ
cord-346853-0c1qdjb5	66	26	arbiters	arbiter	NNS
cord-346853-0c1qdjb5	66	27	over	over	IN
cord-346853-0c1qdjb5	66	28	what	what	WP
cord-346853-0c1qdjb5	66	29	genetic	genetic	JJ
cord-346853-0c1qdjb5	66	30	variation	variation	NN
cord-346853-0c1qdjb5	66	31	remains	remain	VBZ
cord-346853-0c1qdjb5	66	32	in	in	IN
cord-346853-0c1qdjb5	66	33	the	the	DT
cord-346853-0c1qdjb5	66	34	long	long	JJ
cord-346853-0c1qdjb5	66	35	term	term	NN
cord-346853-0c1qdjb5	66	36	.	.	.
cord-346853-0c1qdjb5	67	1	Because	because	IN
cord-346853-0c1qdjb5	67	2	all	all	DT
cord-346853-0c1qdjb5	67	3	viruses	virus	NNS
cord-346853-0c1qdjb5	67	4	have	have	VBP
cord-346853-0c1qdjb5	67	5	an	an	DT
cord-346853-0c1qdjb5	67	6	absolute	absolute	JJ
cord-346853-0c1qdjb5	67	7	dependence	dependence	NN
cord-346853-0c1qdjb5	67	8	on	on	IN
cord-346853-0c1qdjb5	67	9	host	host	NN
cord-346853-0c1qdjb5	67	10	cellular	cellular	JJ
cord-346853-0c1qdjb5	67	11	machinery	machinery	NN
cord-346853-0c1qdjb5	67	12	for	for	IN
cord-346853-0c1qdjb5	67	13	a	a	DT
cord-346853-0c1qdjb5	67	14	productive	productive	JJ
cord-346853-0c1qdjb5	67	15	life	life	NN
cord-346853-0c1qdjb5	67	16	cycle	cycle	NN
cord-346853-0c1qdjb5	67	17	,	,	,
cord-346853-0c1qdjb5	67	18	the	the	DT
cord-346853-0c1qdjb5	67	19	interaction	interaction	NN
cord-346853-0c1qdjb5	67	20	between	between	IN
cord-346853-0c1qdjb5	67	21	viral	viral	JJ
cord-346853-0c1qdjb5	67	22	proteins	protein	NNS
cord-346853-0c1qdjb5	67	23	and	and	CC
cord-346853-0c1qdjb5	67	24	the	the	DT
cord-346853-0c1qdjb5	67	25	cellular	cellular	JJ
cord-346853-0c1qdjb5	67	26	receptors	receptor	NNS
cord-346853-0c1qdjb5	67	27	of	of	IN
cord-346853-0c1qdjb5	67	28	host	host	NN
cord-346853-0c1qdjb5	67	29	cells	cell	NNS
cord-346853-0c1qdjb5	67	30	makes	make	VBZ
cord-346853-0c1qdjb5	67	31	up	up	RP
cord-346853-0c1qdjb5	67	32	a	a	DT
cord-346853-0c1qdjb5	67	33	large	large	JJ
cord-346853-0c1qdjb5	67	34	part	part	NN
cord-346853-0c1qdjb5	67	35	of	of	IN
cord-346853-0c1qdjb5	67	36	the	the	DT
cord-346853-0c1qdjb5	67	37	viruses	virus	NNS
cord-346853-0c1qdjb5	67	38	'	'	POS
cord-346853-0c1qdjb5	67	39	fitness	fitness	NN
cord-346853-0c1qdjb5	67	40	landscape	landscape	NN
cord-346853-0c1qdjb5	67	41	.	.	.
cord-346853-0c1qdjb5	68	1	We	-PRON-	PRP
cord-346853-0c1qdjb5	68	2	would	would	MD
cord-346853-0c1qdjb5	68	3	therefore	therefore	RB
cord-346853-0c1qdjb5	68	4	expect	expect	VB
cord-346853-0c1qdjb5	68	5	the	the	DT
cord-346853-0c1qdjb5	68	6	interaction	interaction	NN
cord-346853-0c1qdjb5	68	7	between	between	IN
cord-346853-0c1qdjb5	68	8	specific	specific	JJ
cord-346853-0c1qdjb5	68	9	viral	viral	JJ
cord-346853-0c1qdjb5	68	10	sequences	sequence	NNS
cord-346853-0c1qdjb5	68	11	and	and	CC
cord-346853-0c1qdjb5	68	12	cellular	cellular	JJ
cord-346853-0c1qdjb5	68	13	receptors	receptor	NNS
cord-346853-0c1qdjb5	68	14	to	to	TO
cord-346853-0c1qdjb5	68	15	be	be	VB
cord-346853-0c1qdjb5	68	16	of	of	IN
cord-346853-0c1qdjb5	68	17	particular	particular	JJ
cord-346853-0c1qdjb5	68	18	importance	importance	NN
cord-346853-0c1qdjb5	68	19	in	in	IN
cord-346853-0c1qdjb5	68	20	determining	determine	VBG
cord-346853-0c1qdjb5	68	21	why	why	WRB
cord-346853-0c1qdjb5	68	22	some	some	DT
cord-346853-0c1qdjb5	68	23	RNA	RNA	NNP
cord-346853-0c1qdjb5	68	24	viruses	virus	NNS
cord-346853-0c1qdjb5	68	25	are	be	VBP
cord-346853-0c1qdjb5	68	26	more	more	RBR
cord-346853-0c1qdjb5	68	27	often	often	RB
cord-346853-0c1qdjb5	68	28	associated	associate	VBN
cord-346853-0c1qdjb5	68	29	with	with	IN
cord-346853-0c1qdjb5	68	30	cross	cross	JJ
cord-346853-0c1qdjb5	68	31	-	-	JJ
cord-346853-0c1qdjb5	68	32	species	species	JJ
cord-346853-0c1qdjb5	68	33	transmission	transmission	NN
cord-346853-0c1qdjb5	68	34	than	than	IN
cord-346853-0c1qdjb5	68	35	others	other	NNS
cord-346853-0c1qdjb5	68	36	(	(	-LRB-
cord-346853-0c1qdjb5	68	37	Baranowski	Baranowski	NNP
cord-346853-0c1qdjb5	68	38	et	et	NNP
cord-346853-0c1qdjb5	68	39	al	al	NNP
cord-346853-0c1qdjb5	68	40	.	.	NNP
cord-346853-0c1qdjb5	68	41	2001	2001	CD
cord-346853-0c1qdjb5	68	42	)	)	-RRB-
cord-346853-0c1qdjb5	68	43	.	.	.
cord-346853-0c1qdjb5	69	1	For	for	IN
cord-346853-0c1qdjb5	69	2	example	example	NN
cord-346853-0c1qdjb5	69	3	,	,	,
cord-346853-0c1qdjb5	69	4	avian	avian	JJ
cord-346853-0c1qdjb5	69	5	influenza	influenza	NN
cord-346853-0c1qdjb5	69	6	A	a	DT
cord-346853-0c1qdjb5	69	7	viruses	virus	NNS
cord-346853-0c1qdjb5	69	8	are	be	VBP
cord-346853-0c1qdjb5	69	9	usually	usually	RB
cord-346853-0c1qdjb5	69	10	unable	unable	JJ
cord-346853-0c1qdjb5	69	11	to	to	TO
cord-346853-0c1qdjb5	69	12	evolve	evolve	VB
cord-346853-0c1qdjb5	69	13	human	human	NN
cord-346853-0c1qdjb5	69	14	-	-	HYPH
cord-346853-0c1qdjb5	69	15	to	to	IN
cord-346853-0c1qdjb5	69	16	-	-	HYPH
cord-346853-0c1qdjb5	69	17	human	human	JJ
cord-346853-0c1qdjb5	69	18	transmission	transmission	NN
cord-346853-0c1qdjb5	69	19	because	because	IN
cord-346853-0c1qdjb5	69	20	they	-PRON-	PRP
cord-346853-0c1qdjb5	69	21	lack	lack	VBP
cord-346853-0c1qdjb5	69	22	the	the	DT
cord-346853-0c1qdjb5	69	23	correct	correct	JJ
cord-346853-0c1qdjb5	69	24	amino	amino	NN
cord-346853-0c1qdjb5	69	25	acids	acid	NNS
cord-346853-0c1qdjb5	69	26	in	in	IN
cord-346853-0c1qdjb5	69	27	a	a	DT
cord-346853-0c1qdjb5	69	28	number	number	NN
cord-346853-0c1qdjb5	69	29	of	of	IN
cord-346853-0c1qdjb5	69	30	viral	viral	JJ
cord-346853-0c1qdjb5	69	31	proteins	protein	NNS
cord-346853-0c1qdjb5	69	32	(	(	-LRB-
cord-346853-0c1qdjb5	69	33	see	see	VB
cord-346853-0c1qdjb5	69	34	the	the	DT
cord-346853-0c1qdjb5	69	35	chapter	chapter	NN
cord-346853-0c1qdjb5	69	36	by	by	IN
cord-346853-0c1qdjb5	69	37	Webby	Webby	NNP
cord-346853-0c1qdjb5	69	38	et	et	NNP
cord-346853-0c1qdjb5	69	39	al	al	NNP
cord-346853-0c1qdjb5	69	40	.	.	NNP
cord-346853-0c1qdjb5	69	41	,	,	,
cord-346853-0c1qdjb5	69	42	this	this	DT
cord-346853-0c1qdjb5	69	43	volume	volume	NN
cord-346853-0c1qdjb5	69	44	)	)	-RRB-
cord-346853-0c1qdjb5	69	45	.	.	.
cord-346853-0c1qdjb5	70	1	Most	Most	JJS
cord-346853-0c1qdjb5	70	2	attention	attention	NN
cord-346853-0c1qdjb5	70	3	has	have	VBZ
cord-346853-0c1qdjb5	70	4	been	be	VBN
cord-346853-0c1qdjb5	70	5	directed	direct	VBN
cord-346853-0c1qdjb5	70	6	toward	toward	IN
cord-346853-0c1qdjb5	70	7	the	the	DT
cord-346853-0c1qdjb5	70	8	viral	viral	JJ
cord-346853-0c1qdjb5	70	9	haemagluttinin	haemagluttinin	NNS
cord-346853-0c1qdjb5	70	10	(	(	-LRB-
cord-346853-0c1qdjb5	70	11	HA	HA	NNP
cord-346853-0c1qdjb5	70	12	)	)	-RRB-
cord-346853-0c1qdjb5	70	13	,	,	,
cord-346853-0c1qdjb5	70	14	which	which	WDT
cord-346853-0c1qdjb5	70	15	requires	require	VBZ
cord-346853-0c1qdjb5	70	16	specific	specific	JJ
cord-346853-0c1qdjb5	70	17	amino	amino	NN
cord-346853-0c1qdjb5	70	18	acids	acid	NNS
cord-346853-0c1qdjb5	70	19	to	to	TO
cord-346853-0c1qdjb5	70	20	interact	interact	VB
cord-346853-0c1qdjb5	70	21	with	with	IN
cord-346853-0c1qdjb5	70	22	the	the	DT
cord-346853-0c1qdjb5	70	23	sialic	sialic	JJ
cord-346853-0c1qdjb5	70	24	receptors	receptor	NNS
cord-346853-0c1qdjb5	70	25	on	on	IN
cord-346853-0c1qdjb5	70	26	human	human	JJ
cord-346853-0c1qdjb5	70	27	cells	cell	NNS
cord-346853-0c1qdjb5	70	28	in	in	IN
cord-346853-0c1qdjb5	70	29	the	the	DT
cord-346853-0c1qdjb5	70	30	correct	correct	JJ
cord-346853-0c1qdjb5	70	31	configuration	configuration	NN
cord-346853-0c1qdjb5	70	32	(	(	-LRB-
cord-346853-0c1qdjb5	70	33	Scholtissek	Scholtissek	NNP
cord-346853-0c1qdjb5	70	34	et	et	NNP
cord-346853-0c1qdjb5	70	35	al	al	NNP
cord-346853-0c1qdjb5	70	36	.	.	.
cord-346853-0c1qdjb5	70	37	1993	1993	CD
cord-346853-0c1qdjb5	70	38	;	;	:
cord-346853-0c1qdjb5	70	39	see	see	VB
cord-346853-0c1qdjb5	70	40	Sect	Sect	NNP
cord-346853-0c1qdjb5	70	41	.	.	.
cord-346853-0c1qdjb5	71	1	4	4	LS
cord-346853-0c1qdjb5	71	2	)	)	-RRB-
cord-346853-0c1qdjb5	71	3	.	.	.
cord-346853-0c1qdjb5	72	1	The	the	DT
cord-346853-0c1qdjb5	72	2	intimacy	intimacy	NN
cord-346853-0c1qdjb5	72	3	of	of	IN
cord-346853-0c1qdjb5	72	4	the	the	DT
cord-346853-0c1qdjb5	72	5	relationship	relationship	NN
cord-346853-0c1qdjb5	72	6	between	between	IN
cord-346853-0c1qdjb5	72	7	virus	virus	NN
cord-346853-0c1qdjb5	72	8	and	and	CC
cord-346853-0c1qdjb5	72	9	cell	cell	NN
cord-346853-0c1qdjb5	72	10	receptor	receptor	NN
cord-346853-0c1qdjb5	72	11	also	also	RB
cord-346853-0c1qdjb5	72	12	predicts	predict	VBZ
cord-346853-0c1qdjb5	72	13	that	that	IN
cord-346853-0c1qdjb5	72	14	generalist	generalist	NN
cord-346853-0c1qdjb5	72	15	viruses	virus	NNS
cord-346853-0c1qdjb5	72	16	,	,	,
cord-346853-0c1qdjb5	72	17	which	which	WDT
cord-346853-0c1qdjb5	72	18	infect	infect	VBP
cord-346853-0c1qdjb5	72	19	a	a	DT
cord-346853-0c1qdjb5	72	20	broad	broad	JJ
cord-346853-0c1qdjb5	72	21	range	range	NN
cord-346853-0c1qdjb5	72	22	of	of	IN
cord-346853-0c1qdjb5	72	23	cellular	cellular	JJ
cord-346853-0c1qdjb5	72	24	receptors	receptor	NNS
cord-346853-0c1qdjb5	72	25	,	,	,
cord-346853-0c1qdjb5	72	26	are	be	VBP
cord-346853-0c1qdjb5	72	27	more	more	RBR
cord-346853-0c1qdjb5	72	28	able	able	JJ
cord-346853-0c1qdjb5	72	29	to	to	TO
cord-346853-0c1qdjb5	72	30	cross	cross	VB
cord-346853-0c1qdjb5	72	31	species	species	NN
cord-346853-0c1qdjb5	72	32	boundaries	boundary	NNS
cord-346853-0c1qdjb5	72	33	than	than	IN
cord-346853-0c1qdjb5	72	34	specialist	specialist	NN
cord-346853-0c1qdjb5	72	35	viruses	virus	NNS
cord-346853-0c1qdjb5	72	36	that	that	WDT
cord-346853-0c1qdjb5	72	37	have	have	VBP
cord-346853-0c1qdjb5	72	38	a	a	DT
cord-346853-0c1qdjb5	72	39	narrower	narrow	JJR
cord-346853-0c1qdjb5	72	40	tropism	tropism	NN
cord-346853-0c1qdjb5	72	41	.	.	.
cord-346853-0c1qdjb5	73	1	Strikingly	strikingly	RB
cord-346853-0c1qdjb5	73	2	,	,	,
cord-346853-0c1qdjb5	73	3	provisional	provisional	JJ
cord-346853-0c1qdjb5	73	4	analyses	analysis	NNS
cord-346853-0c1qdjb5	73	5	suggest	suggest	VBP
cord-346853-0c1qdjb5	73	6	that	that	IN
cord-346853-0c1qdjb5	73	7	this	this	DT
cord-346853-0c1qdjb5	73	8	is	be	VBZ
cord-346853-0c1qdjb5	73	9	indeed	indeed	RB
cord-346853-0c1qdjb5	73	10	the	the	DT
cord-346853-0c1qdjb5	73	11	case	case	NN
cord-346853-0c1qdjb5	73	12	,	,	,
cord-346853-0c1qdjb5	73	13	as	as	IN
cord-346853-0c1qdjb5	73	14	viruses	virus	NNS
cord-346853-0c1qdjb5	73	15	that	that	WDT
cord-346853-0c1qdjb5	73	16	utilize	utilize	VBP
cord-346853-0c1qdjb5	73	17	conserved	conserved	JJ
cord-346853-0c1qdjb5	73	18	cell	cell	NN
cord-346853-0c1qdjb5	73	19	receptors	receptor	NNS
cord-346853-0c1qdjb5	73	20	are	be	VBP
cord-346853-0c1qdjb5	73	21	more	more	RBR
cord-346853-0c1qdjb5	73	22	able	able	JJ
cord-346853-0c1qdjb5	73	23	to	to	TO
cord-346853-0c1qdjb5	73	24	jump	jump	VB
cord-346853-0c1qdjb5	73	25	species	species	NN
cord-346853-0c1qdjb5	73	26	boundaries	boundary	NNS
cord-346853-0c1qdjb5	73	27	than	than	IN
cord-346853-0c1qdjb5	73	28	viruses	virus	NNS
cord-346853-0c1qdjb5	73	29	that	that	WDT
cord-346853-0c1qdjb5	73	30	use	use	VBP
cord-346853-0c1qdjb5	73	31	divergent	divergent	JJ
cord-346853-0c1qdjb5	73	32	cell	cell	NN
cord-346853-0c1qdjb5	73	33	receptors	receptor	NNS
cord-346853-0c1qdjb5	73	34	(	(	-LRB-
cord-346853-0c1qdjb5	73	35	Woolhouse	Woolhouse	NNP
cord-346853-0c1qdjb5	73	36	2002	2002	CD
cord-346853-0c1qdjb5	73	37	)	)	-RRB-
cord-346853-0c1qdjb5	73	38	.	.	.
cord-346853-0c1qdjb5	74	1	If	if	IN
cord-346853-0c1qdjb5	74	2	validated	validate	VBN
cord-346853-0c1qdjb5	74	3	with	with	IN
cord-346853-0c1qdjb5	74	4	more	more	JJR
cord-346853-0c1qdjb5	74	5	data	datum	NNS
cord-346853-0c1qdjb5	74	6	,	,	,
cord-346853-0c1qdjb5	74	7	this	this	DT
cord-346853-0c1qdjb5	74	8	result	result	NN
cord-346853-0c1qdjb5	74	9	is	be	VBZ
cord-346853-0c1qdjb5	74	10	of	of	IN
cord-346853-0c1qdjb5	74	11	great	great	JJ
cord-346853-0c1qdjb5	74	12	importance	importance	NN
cord-346853-0c1qdjb5	74	13	because	because	IN
cord-346853-0c1qdjb5	74	14	it	-PRON-	PRP
cord-346853-0c1qdjb5	74	15	allows	allow	VBZ
cord-346853-0c1qdjb5	74	16	predictions	prediction	NNS
cord-346853-0c1qdjb5	74	17	to	to	TO
cord-346853-0c1qdjb5	74	18	be	be	VB
cord-346853-0c1qdjb5	74	19	made	make	VBN
cord-346853-0c1qdjb5	74	20	as	as	IN
cord-346853-0c1qdjb5	74	21	to	to	IN
cord-346853-0c1qdjb5	74	22	the	the	DT
cord-346853-0c1qdjb5	74	23	types	type	NNS
cord-346853-0c1qdjb5	74	24	of	of	IN
cord-346853-0c1qdjb5	74	25	virus	virus	NN
cord-346853-0c1qdjb5	74	26	that	that	WDT
cord-346853-0c1qdjb5	74	27	are	be	VBP
cord-346853-0c1qdjb5	74	28	most	most	RBS
cord-346853-0c1qdjb5	74	29	likely	likely	JJ
cord-346853-0c1qdjb5	74	30	to	to	TO
cord-346853-0c1qdjb5	74	31	emerge	emerge	VB
cord-346853-0c1qdjb5	74	32	in	in	IN
cord-346853-0c1qdjb5	74	33	the	the	DT
cord-346853-0c1qdjb5	74	34	future	future	NN
cord-346853-0c1qdjb5	74	35	.	.	.
cord-346853-0c1qdjb5	75	1	Another	another	DT
cord-346853-0c1qdjb5	75	2	factor	factor	NN
cord-346853-0c1qdjb5	75	3	that	that	WDT
cord-346853-0c1qdjb5	75	4	might	may	MD
cord-346853-0c1qdjb5	75	5	influence	influence	VB
cord-346853-0c1qdjb5	75	6	the	the	DT
cord-346853-0c1qdjb5	75	7	ability	ability	NN
cord-346853-0c1qdjb5	75	8	of	of	IN
cord-346853-0c1qdjb5	75	9	viruses	virus	NNS
cord-346853-0c1qdjb5	75	10	to	to	TO
cord-346853-0c1qdjb5	75	11	cross	cross	VB
cord-346853-0c1qdjb5	75	12	species	species	NN
cord-346853-0c1qdjb5	75	13	boundaries	boundary	NNS
cord-346853-0c1qdjb5	75	14	is	be	VBZ
cord-346853-0c1qdjb5	75	15	the	the	DT
cord-346853-0c1qdjb5	75	16	mode	mode	NN
cord-346853-0c1qdjb5	75	17	of	of	IN
cord-346853-0c1qdjb5	75	18	transmission	transmission	NN
cord-346853-0c1qdjb5	75	19	.	.	.
cord-346853-0c1qdjb5	76	1	It	-PRON-	PRP
cord-346853-0c1qdjb5	76	2	is	be	VBZ
cord-346853-0c1qdjb5	76	3	easy	easy	JJ
cord-346853-0c1qdjb5	76	4	to	to	TO
cord-346853-0c1qdjb5	76	5	imagine	imagine	VB
cord-346853-0c1qdjb5	76	6	how	how	WRB
cord-346853-0c1qdjb5	76	7	certain	certain	JJ
cord-346853-0c1qdjb5	76	8	types	type	NNS
cord-346853-0c1qdjb5	76	9	of	of	IN
cord-346853-0c1qdjb5	76	10	transmission	transmission	NN
cord-346853-0c1qdjb5	76	11	mechanism	mechanism	NN
cord-346853-0c1qdjb5	76	12	-	-	:
cord-346853-0c1qdjb5	76	13	particularly	particularly	RB
cord-346853-0c1qdjb5	76	14	respiratory	respiratory	JJ
cord-346853-0c1qdjb5	76	15	and	and	CC
cord-346853-0c1qdjb5	76	16	vector	vector	NN
cord-346853-0c1qdjb5	76	17	-	-	HYPH
cord-346853-0c1qdjb5	76	18	borne	bear	VBN
cord-346853-0c1qdjb5	76	19	transmission	transmission	NN
cord-346853-0c1qdjb5	76	20	-	-	:
cord-346853-0c1qdjb5	76	21	might	may	MD
cord-346853-0c1qdjb5	76	22	more	more	RBR
cord-346853-0c1qdjb5	76	23	readily	readily	RB
cord-346853-0c1qdjb5	76	24	facilitate	facilitate	VB
cord-346853-0c1qdjb5	76	25	viral	viral	JJ
cord-346853-0c1qdjb5	76	26	emergence	emergence	NN
cord-346853-0c1qdjb5	76	27	than	than	IN
cord-346853-0c1qdjb5	76	28	others	other	NNS
cord-346853-0c1qdjb5	76	29	.	.	.
cord-346853-0c1qdjb5	77	1	In	in	IN
cord-346853-0c1qdjb5	77	2	both	both	PDT
cord-346853-0c1qdjb5	77	3	these	these	DT
cord-346853-0c1qdjb5	77	4	cases	case	NNS
cord-346853-0c1qdjb5	77	5	,	,	,
cord-346853-0c1qdjb5	77	6	the	the	DT
cord-346853-0c1qdjb5	77	7	probability	probability	NN
cord-346853-0c1qdjb5	77	8	of	of	IN
cord-346853-0c1qdjb5	77	9	exposure	exposure	NN
cord-346853-0c1qdjb5	77	10	to	to	IN
cord-346853-0c1qdjb5	77	11	an	an	DT
cord-346853-0c1qdjb5	77	12	emergent	emergent	JJ
cord-346853-0c1qdjb5	77	13	virus	virus	NN
cord-346853-0c1qdjb5	77	14	is	be	VBZ
cord-346853-0c1qdjb5	77	15	relatively	relatively	RB
cord-346853-0c1qdjb5	77	16	high	high	JJ
cord-346853-0c1qdjb5	77	17	compared	compare	VBN
cord-346853-0c1qdjb5	77	18	to	to	IN
cord-346853-0c1qdjb5	77	19	viruses	virus	NNS
cord-346853-0c1qdjb5	77	20	that	that	WDT
cord-346853-0c1qdjb5	77	21	are	be	VBP
cord-346853-0c1qdjb5	77	22	blood	blood	NN
cord-346853-0c1qdjb5	77	23	-	-	HYPH
cord-346853-0c1qdjb5	77	24	borne	bear	VBN
cord-346853-0c1qdjb5	77	25	or	or	CC
cord-346853-0c1qdjb5	77	26	sexually	sexually	RB
cord-346853-0c1qdjb5	77	27	transmitted	transmit	VBN
cord-346853-0c1qdjb5	77	28	.	.	.
cord-346853-0c1qdjb5	78	1	Indeed	indeed	RB
cord-346853-0c1qdjb5	78	2	,	,	,
cord-346853-0c1qdjb5	78	3	it	-PRON-	PRP
cord-346853-0c1qdjb5	78	4	is	be	VBZ
cord-346853-0c1qdjb5	78	5	striking	strike	VBG
cord-346853-0c1qdjb5	78	6	that	that	IN
cord-346853-0c1qdjb5	78	7	many	many	JJ
cord-346853-0c1qdjb5	78	8	of	of	IN
cord-346853-0c1qdjb5	78	9	the	the	DT
cord-346853-0c1qdjb5	78	10	viruses	virus	NNS
cord-346853-0c1qdjb5	78	11	described	describe	VBN
cord-346853-0c1qdjb5	78	12	in	in	IN
cord-346853-0c1qdjb5	78	13	the	the	DT
cord-346853-0c1qdjb5	78	14	earliest	early	JJS
cord-346853-0c1qdjb5	78	15	lists	list	NNS
cord-346853-0c1qdjb5	78	16	of	of	IN
cord-346853-0c1qdjb5	78	17	emerging	emerge	VBG
cord-346853-0c1qdjb5	78	18	viruses	virus	NNS
cord-346853-0c1qdjb5	78	19	were	be	VBD
cord-346853-0c1qdjb5	78	20	transmitted	transmit	VBN
cord-346853-0c1qdjb5	78	21	by	by	IN
cord-346853-0c1qdjb5	78	22	mosquito	mosquito	NN
cord-346853-0c1qdjb5	78	23	vectors	vector	NNS
cord-346853-0c1qdjb5	78	24	(	(	-LRB-
cord-346853-0c1qdjb5	78	25	the	the	DT
cord-346853-0c1qdjb5	78	26	arboviruses	arboviruses	NNP
cord-346853-0c1qdjb5	78	27	)	)	-RRB-
cord-346853-0c1qdjb5	78	28	,	,	,
cord-346853-0c1qdjb5	78	29	which	which	WDT
cord-346853-0c1qdjb5	78	30	could	could	MD
cord-346853-0c1qdjb5	78	31	potentially	potentially	RB
cord-346853-0c1qdjb5	78	32	take	take	VB
cord-346853-0c1qdjb5	78	33	blood	blood	NN
cord-346853-0c1qdjb5	78	34	meals	meal	NNS
cord-346853-0c1qdjb5	78	35	from	from	IN
cord-346853-0c1qdjb5	78	36	a	a	DT
cord-346853-0c1qdjb5	78	37	range	range	NN
cord-346853-0c1qdjb5	78	38	of	of	IN
cord-346853-0c1qdjb5	78	39	mammalian	mammalian	JJ
cord-346853-0c1qdjb5	78	40	hosts	host	NNS
cord-346853-0c1qdjb5	78	41	.	.	.
cord-346853-0c1qdjb5	79	1	However	however	RB
cord-346853-0c1qdjb5	79	2	,	,	,
cord-346853-0c1qdjb5	79	3	although	although	IN
cord-346853-0c1qdjb5	79	4	an	an	DT
cord-346853-0c1qdjb5	79	5	increased	increase	VBN
cord-346853-0c1qdjb5	79	6	probability	probability	NN
cord-346853-0c1qdjb5	79	7	of	of	IN
cord-346853-0c1qdjb5	79	8	exposure	exposure	NN
cord-346853-0c1qdjb5	79	9	will	will	MD
cord-346853-0c1qdjb5	79	10	generally	generally	RB
cord-346853-0c1qdjb5	79	11	translate	translate	VB
cord-346853-0c1qdjb5	79	12	into	into	IN
cord-346853-0c1qdjb5	79	13	an	an	DT
cord-346853-0c1qdjb5	79	14	increased	increase	VBN
cord-346853-0c1qdjb5	79	15	likelihood	likelihood	NN
cord-346853-0c1qdjb5	79	16	of	of	IN
cord-346853-0c1qdjb5	79	17	emergence	emergence	NN
cord-346853-0c1qdjb5	79	18	(	(	-LRB-
cord-346853-0c1qdjb5	79	19	see	see	VB
cord-346853-0c1qdjb5	79	20	the	the	DT
cord-346853-0c1qdjb5	79	21	chapters	chapter	NNS
cord-346853-0c1qdjb5	79	22	by	by	IN
cord-346853-0c1qdjb5	79	23	Childs	Childs	NNP
cord-346853-0c1qdjb5	79	24	et	et	NNP
cord-346853-0c1qdjb5	79	25	al	al	NNP
cord-346853-0c1qdjb5	79	26	.	.	.
cord-346853-0c1qdjb5	80	1	and	and	CC
cord-346853-0c1qdjb5	80	2	Real	Real	NNP
cord-346853-0c1qdjb5	80	3	and	and	CC
cord-346853-0c1qdjb5	80	4	Biek	Biek	NNP
cord-346853-0c1qdjb5	80	5	,	,	,
cord-346853-0c1qdjb5	80	6	this	this	DT
cord-346853-0c1qdjb5	80	7	volume	volume	NN
cord-346853-0c1qdjb5	80	8	)	)	-RRB-
cord-346853-0c1qdjb5	80	9	,	,	,
cord-346853-0c1qdjb5	80	10	there	there	EX
cord-346853-0c1qdjb5	80	11	are	be	VBP
cord-346853-0c1qdjb5	80	12	a	a	DT
cord-346853-0c1qdjb5	80	13	number	number	NN
cord-346853-0c1qdjb5	80	14	of	of	IN
cord-346853-0c1qdjb5	80	15	other	other	JJ
cord-346853-0c1qdjb5	80	16	factors	factor	NNS
cord-346853-0c1qdjb5	80	17	that	that	WDT
cord-346853-0c1qdjb5	80	18	this	this	DT
cord-346853-0c1qdjb5	80	19	simple	simple	JJ
cord-346853-0c1qdjb5	80	20	calculus	calculus	NN
cord-346853-0c1qdjb5	80	21	omits	omit	VBZ
cord-346853-0c1qdjb5	80	22	.	.	.
cord-346853-0c1qdjb5	81	1	For	for	IN
cord-346853-0c1qdjb5	81	2	example	example	NN
cord-346853-0c1qdjb5	81	3	,	,	,
cord-346853-0c1qdjb5	81	4	there	there	EX
cord-346853-0c1qdjb5	81	5	appears	appear	VBZ
cord-346853-0c1qdjb5	81	6	to	to	TO
cord-346853-0c1qdjb5	81	7	be	be	VB
cord-346853-0c1qdjb5	81	8	an	an	DT
cord-346853-0c1qdjb5	81	9	association	association	NN
cord-346853-0c1qdjb5	81	10	between	between	IN
cord-346853-0c1qdjb5	81	11	mode	mode	NN
cord-346853-0c1qdjb5	81	12	of	of	IN
cord-346853-0c1qdjb5	81	13	transmission	transmission	NN
cord-346853-0c1qdjb5	81	14	and	and	CC
cord-346853-0c1qdjb5	81	15	the	the	DT
cord-346853-0c1qdjb5	81	16	ability	ability	NN
cord-346853-0c1qdjb5	81	17	of	of	IN
cord-346853-0c1qdjb5	81	18	a	a	DT
cord-346853-0c1qdjb5	81	19	virus	virus	NN
cord-346853-0c1qdjb5	81	20	to	to	TO
cord-346853-0c1qdjb5	81	21	successfully	successfully	RB
cord-346853-0c1qdjb5	81	22	replicate	replicate	VB
cord-346853-0c1qdjb5	81	23	in	in	IN
cord-346853-0c1qdjb5	81	24	the	the	DT
cord-346853-0c1qdjb5	81	25	cells	cell	NNS
cord-346853-0c1qdjb5	81	26	of	of	IN
cord-346853-0c1qdjb5	81	27	a	a	DT
cord-346853-0c1qdjb5	81	28	new	new	JJ
cord-346853-0c1qdjb5	81	29	host	host	NN
cord-346853-0c1qdjb5	81	30	species	specie	NNS
cord-346853-0c1qdjb5	81	31	.	.	.
cord-346853-0c1qdjb5	82	1	This	this	DT
cord-346853-0c1qdjb5	82	2	is	be	VBZ
cord-346853-0c1qdjb5	82	3	best	well	RBS
cord-346853-0c1qdjb5	82	4	documented	document	VBN
cord-346853-0c1qdjb5	82	5	with	with	IN
cord-346853-0c1qdjb5	82	6	the	the	DT
cord-346853-0c1qdjb5	82	7	arboviruses	arbovirus	NNS
cord-346853-0c1qdjb5	82	8	where	where	WRB
cord-346853-0c1qdjb5	82	9	there	there	EX
cord-346853-0c1qdjb5	82	10	is	be	VBZ
cord-346853-0c1qdjb5	82	11	strong	strong	JJ
cord-346853-0c1qdjb5	82	12	evidence	evidence	NN
cord-346853-0c1qdjb5	82	13	from	from	IN
cord-346853-0c1qdjb5	82	14	both	both	CC
cord-346853-0c1qdjb5	82	15	comparative	comparative	JJ
cord-346853-0c1qdjb5	82	16	and	and	CC
cord-346853-0c1qdjb5	82	17	in	in	IN
cord-346853-0c1qdjb5	82	18	vitro	vitro	FW
cord-346853-0c1qdjb5	82	19	studies	study	NNS
cord-346853-0c1qdjb5	82	20	that	that	WDT
cord-346853-0c1qdjb5	82	21	the	the	DT
cord-346853-0c1qdjb5	82	22	necessity	necessity	NN
cord-346853-0c1qdjb5	82	23	of	of	IN
cord-346853-0c1qdjb5	82	24	replicating	replicate	VBG
cord-346853-0c1qdjb5	82	25	in	in	IN
cord-346853-0c1qdjb5	82	26	very	very	RB
cord-346853-0c1qdjb5	82	27	different	different	JJ
cord-346853-0c1qdjb5	82	28	host	host	NN
cord-346853-0c1qdjb5	82	29	species	specie	NNS
cord-346853-0c1qdjb5	82	30	,	,	,
cord-346853-0c1qdjb5	82	31	in	in	IN
cord-346853-0c1qdjb5	82	32	this	this	DT
cord-346853-0c1qdjb5	82	33	case	case	NN
cord-346853-0c1qdjb5	82	34	arthropods	arthropod	NNS
cord-346853-0c1qdjb5	82	35	and	and	CC
cord-346853-0c1qdjb5	82	36	mammals	mammal	NNS
cord-346853-0c1qdjb5	82	37	,	,	,
cord-346853-0c1qdjb5	82	38	imposes	impose	VBZ
cord-346853-0c1qdjb5	82	39	strong	strong	JJ
cord-346853-0c1qdjb5	82	40	constraints	constraint	NNS
cord-346853-0c1qdjb5	82	41	against	against	IN
cord-346853-0c1qdjb5	82	42	sequence	sequence	NN
cord-346853-0c1qdjb5	82	43	change	change	NN
cord-346853-0c1qdjb5	82	44	(	(	-LRB-
cord-346853-0c1qdjb5	82	45	Holmes	Holmes	NNP
cord-346853-0c1qdjb5	82	46	2003b	2003b	NNS
cord-346853-0c1qdjb5	82	47	;	;	:
cord-346853-0c1qdjb5	82	48	Woelk	Woelk	NNP
cord-346853-0c1qdjb5	82	49	and	and	CC
cord-346853-0c1qdjb5	82	50	Holmes	Holmes	NNP
cord-346853-0c1qdjb5	82	51	2002	2002	CD
cord-346853-0c1qdjb5	82	52	;	;	:
cord-346853-0c1qdjb5	82	53	Zárate	Zárate	NNP
cord-346853-0c1qdjb5	82	54	and	and	CC
cord-346853-0c1qdjb5	82	55	Novella	Novella	NNP
cord-346853-0c1qdjb5	82	56	2004	2004	CD
cord-346853-0c1qdjb5	82	57	)	)	-RRB-
cord-346853-0c1qdjb5	82	58	.	.	.
cord-346853-0c1qdjb5	83	1	This	this	DT
cord-346853-0c1qdjb5	83	2	effect	effect	NN
cord-346853-0c1qdjb5	83	3	is	be	VBZ
cord-346853-0c1qdjb5	83	4	most	most	RBS
cord-346853-0c1qdjb5	83	5	likely	likely	RB
cord-346853-0c1qdjb5	83	6	attributable	attributable	JJ
cord-346853-0c1qdjb5	83	7	to	to	IN
cord-346853-0c1qdjb5	83	8	an	an	DT
cord-346853-0c1qdjb5	83	9	antagonistic	antagonistic	JJ
cord-346853-0c1qdjb5	83	10	fitness	fitness	NN
cord-346853-0c1qdjb5	83	11	trade	trade	NN
cord-346853-0c1qdjb5	83	12	-	-	HYPH
cord-346853-0c1qdjb5	83	13	off	off	NN
cord-346853-0c1qdjb5	83	14	,	,	,
cord-346853-0c1qdjb5	83	15	such	such	JJ
cord-346853-0c1qdjb5	83	16	that	that	IN
cord-346853-0c1qdjb5	83	17	mutations	mutation	NNS
cord-346853-0c1qdjb5	83	18	that	that	WDT
cord-346853-0c1qdjb5	83	19	increase	increase	VBP
cord-346853-0c1qdjb5	83	20	fitness	fitness	NN
cord-346853-0c1qdjb5	83	21	in	in	IN
cord-346853-0c1qdjb5	83	22	one	one	CD
cord-346853-0c1qdjb5	83	23	host	host	NN
cord-346853-0c1qdjb5	83	24	species	specie	NNS
cord-346853-0c1qdjb5	83	25	reduce	reduce	VBP
cord-346853-0c1qdjb5	83	26	it	-PRON-	PRP
cord-346853-0c1qdjb5	83	27	in	in	IN
cord-346853-0c1qdjb5	83	28	another	another	DT
cord-346853-0c1qdjb5	83	29	.	.	.
cord-346853-0c1qdjb5	84	1	Hence	hence	RB
cord-346853-0c1qdjb5	84	2	,	,	,
cord-346853-0c1qdjb5	84	3	the	the	DT
cord-346853-0c1qdjb5	84	4	majority	majority	NN
cord-346853-0c1qdjb5	84	5	of	of	IN
cord-346853-0c1qdjb5	84	6	amino	amino	NN
cord-346853-0c1qdjb5	84	7	acid	acid	NN
cord-346853-0c1qdjb5	84	8	changes	change	NNS
cord-346853-0c1qdjb5	84	9	that	that	WDT
cord-346853-0c1qdjb5	84	10	arise	arise	VBP
cord-346853-0c1qdjb5	84	11	in	in	IN
cord-346853-0c1qdjb5	84	12	either	either	DT
cord-346853-0c1qdjb5	84	13	host	host	NN
cord-346853-0c1qdjb5	84	14	are	be	VBP
cord-346853-0c1qdjb5	84	15	deleterious	deleterious	JJ
cord-346853-0c1qdjb5	84	16	(	(	-LRB-
cord-346853-0c1qdjb5	84	17	or	or	CC
cord-346853-0c1qdjb5	84	18	slightly	slightly	RB
cord-346853-0c1qdjb5	84	19	deleterious	deleterious	JJ
cord-346853-0c1qdjb5	84	20	)	)	-RRB-
cord-346853-0c1qdjb5	84	21	and	and	CC
cord-346853-0c1qdjb5	84	22	eventually	eventually	RB
cord-346853-0c1qdjb5	84	23	removed	remove	VBN
cord-346853-0c1qdjb5	84	24	by	by	IN
cord-346853-0c1qdjb5	84	25	purifying	purify	VBG
cord-346853-0c1qdjb5	84	26	selection	selection	NN
cord-346853-0c1qdjb5	84	27	.	.	.
cord-346853-0c1qdjb5	85	1	In	in	IN
cord-346853-0c1qdjb5	85	2	particular	particular	JJ
cord-346853-0c1qdjb5	85	3	,	,	,
cord-346853-0c1qdjb5	85	4	it	-PRON-	PRP
cord-346853-0c1qdjb5	85	5	seems	seem	VBZ
cord-346853-0c1qdjb5	85	6	especially	especially	RB
cord-346853-0c1qdjb5	85	7	difficult	difficult	JJ
cord-346853-0c1qdjb5	85	8	to	to	TO
cord-346853-0c1qdjb5	85	9	establish	establish	VB
cord-346853-0c1qdjb5	85	10	productive	productive	JJ
cord-346853-0c1qdjb5	85	11	infections	infection	NNS
cord-346853-0c1qdjb5	85	12	in	in	IN
cord-346853-0c1qdjb5	85	13	insect	insect	NN
cord-346853-0c1qdjb5	85	14	cells	cell	NNS
cord-346853-0c1qdjb5	85	15	(	(	-LRB-
cord-346853-0c1qdjb5	85	16	Zárate	Zárate	NNP
cord-346853-0c1qdjb5	85	17	and	and	CC
cord-346853-0c1qdjb5	85	18	Novella	Novella	NNP
cord-346853-0c1qdjb5	85	19	2004	2004	CD
cord-346853-0c1qdjb5	85	20	)	)	-RRB-
cord-346853-0c1qdjb5	85	21	,	,	,
cord-346853-0c1qdjb5	85	22	which	which	WDT
cord-346853-0c1qdjb5	85	23	perhaps	perhaps	RB
cord-346853-0c1qdjb5	85	24	explains	explain	VBZ
cord-346853-0c1qdjb5	85	25	why	why	WRB
cord-346853-0c1qdjb5	85	26	vector	vector	NN
cord-346853-0c1qdjb5	85	27	species	specie	NNS
cord-346853-0c1qdjb5	85	28	seems	seem	VBZ
cord-346853-0c1qdjb5	85	29	to	to	TO
cord-346853-0c1qdjb5	85	30	be	be	VB
cord-346853-0c1qdjb5	85	31	a	a	DT
cord-346853-0c1qdjb5	85	32	key	key	JJ
cord-346853-0c1qdjb5	85	33	correlate	correlate	NN
cord-346853-0c1qdjb5	85	34	of	of	IN
cord-346853-0c1qdjb5	85	35	evolution	evolution	NN
cord-346853-0c1qdjb5	85	36	in	in	IN
cord-346853-0c1qdjb5	85	37	some	some	DT
cord-346853-0c1qdjb5	85	38	animal	animal	NN
cord-346853-0c1qdjb5	85	39	and	and	CC
cord-346853-0c1qdjb5	85	40	plant	plant	NN
cord-346853-0c1qdjb5	85	41	RNA	RNA	NNP
cord-346853-0c1qdjb5	85	42	viruses	virus	NNS
cord-346853-0c1qdjb5	85	43	(	(	-LRB-
cord-346853-0c1qdjb5	85	44	Gaunt	Gaunt	NNP
cord-346853-0c1qdjb5	85	45	et	et	FW
cord-346853-0c1qdjb5	85	46	al	al	NNP
cord-346853-0c1qdjb5	85	47	.	.	NNP
cord-346853-0c1qdjb5	85	48	2001	2001	CD
cord-346853-0c1qdjb5	85	49	;	;	:
cord-346853-0c1qdjb5	85	50	Chare	Chare	NNP
cord-346853-0c1qdjb5	85	51	and	and	CC
cord-346853-0c1qdjb5	85	52	Holmes	Holmes	NNP
cord-346853-0c1qdjb5	85	53	2004	2004	CD
cord-346853-0c1qdjb5	85	54	)	)	-RRB-
cord-346853-0c1qdjb5	85	55	.	.	.
cord-346853-0c1qdjb5	86	1	However	however	RB
cord-346853-0c1qdjb5	86	2	,	,	,
cord-346853-0c1qdjb5	86	3	perhaps	perhaps	RB
cord-346853-0c1qdjb5	86	4	the	the	DT
cord-346853-0c1qdjb5	86	5	most	most	RBS
cord-346853-0c1qdjb5	86	6	striking	striking	JJ
cord-346853-0c1qdjb5	86	7	of	of	IN
cord-346853-0c1qdjb5	86	8	all	all	DT
cord-346853-0c1qdjb5	86	9	observations	observation	NNS
cord-346853-0c1qdjb5	86	10	in	in	IN
cord-346853-0c1qdjb5	86	11	this	this	DT
cord-346853-0c1qdjb5	86	12	context	context	NN
cord-346853-0c1qdjb5	86	13	is	be	VBZ
cord-346853-0c1qdjb5	86	14	that	that	IN
cord-346853-0c1qdjb5	86	15	although	although	IN
cord-346853-0c1qdjb5	86	16	arboviruses	arbovirus	NNS
cord-346853-0c1qdjb5	86	17	are	be	VBP
cord-346853-0c1qdjb5	86	18	frequently	frequently	RB
cord-346853-0c1qdjb5	86	19	associated	associate	VBN
cord-346853-0c1qdjb5	86	20	with	with	IN
cord-346853-0c1qdjb5	86	21	sporadic	sporadic	JJ
cord-346853-0c1qdjb5	86	22	disease	disease	NN
cord-346853-0c1qdjb5	86	23	in	in	IN
cord-346853-0c1qdjb5	86	24	humans	human	NNS
cord-346853-0c1qdjb5	86	25	,	,	,
cord-346853-0c1qdjb5	86	26	few	few	JJ
cord-346853-0c1qdjb5	86	27	are	be	VBP
cord-346853-0c1qdjb5	86	28	able	able	JJ
cord-346853-0c1qdjb5	86	29	to	to	TO
cord-346853-0c1qdjb5	86	30	sustain	sustain	VB
cord-346853-0c1qdjb5	86	31	long	long	JJ
cord-346853-0c1qdjb5	86	32	-	-	HYPH
cord-346853-0c1qdjb5	86	33	term	term	NN
cord-346853-0c1qdjb5	86	34	transmission	transmission	NN
cord-346853-0c1qdjb5	86	35	networks	network	NNS
cord-346853-0c1qdjb5	86	36	and	and	CC
cord-346853-0c1qdjb5	86	37	dead	dead	JJ
cord-346853-0c1qdjb5	86	38	-	-	HYPH
cord-346853-0c1qdjb5	86	39	end	end	NN
cord-346853-0c1qdjb5	86	40	infections	infection	NNS
cord-346853-0c1qdjb5	86	41	are	be	VBP
cord-346853-0c1qdjb5	86	42	commonplace	commonplace	JJ
cord-346853-0c1qdjb5	87	1	(	(	-LRB-
cord-346853-0c1qdjb5	87	2	M.E.J.	M.E.J.	NNP
cord-346853-0c1qdjb5	87	3	Woolhouse	Woolhouse	NNP
cord-346853-0c1qdjb5	87	4	,	,	,
cord-346853-0c1qdjb5	87	5	personal	personal	JJ
cord-346853-0c1qdjb5	87	6	communication	communication	NN
cord-346853-0c1qdjb5	87	7	)	)	-RRB-
cord-346853-0c1qdjb5	87	8	.	.	.
cord-346853-0c1qdjb5	88	1	Hence	hence	RB
cord-346853-0c1qdjb5	88	2	,	,	,
cord-346853-0c1qdjb5	88	3	the	the	DT
cord-346853-0c1qdjb5	88	4	intricate	intricate	JJ
cord-346853-0c1qdjb5	88	5	adaptations	adaptation	NNS
cord-346853-0c1qdjb5	88	6	to	to	TO
cord-346853-0c1qdjb5	88	7	replicate	replicate	VB
cord-346853-0c1qdjb5	88	8	in	in	IN
cord-346853-0c1qdjb5	88	9	divergent	divergent	JJ
cord-346853-0c1qdjb5	88	10	hosts	host	NNS
cord-346853-0c1qdjb5	88	11	may	may	MD
cord-346853-0c1qdjb5	88	12	act	act	VB
cord-346853-0c1qdjb5	88	13	to	to	TO
cord-346853-0c1qdjb5	88	14	prevent	prevent	VB
cord-346853-0c1qdjb5	88	15	many	many	JJ
cord-346853-0c1qdjb5	88	16	arboviruses	arbovirus	NNS
cord-346853-0c1qdjb5	88	17	from	from	IN
cord-346853-0c1qdjb5	88	18	successful	successful	JJ
cord-346853-0c1qdjb5	88	19	emergence	emergence	NN
cord-346853-0c1qdjb5	88	20	in	in	IN
cord-346853-0c1qdjb5	88	21	new	new	JJ
cord-346853-0c1qdjb5	88	22	host	host	NN
cord-346853-0c1qdjb5	88	23	species	specie	NNS
cord-346853-0c1qdjb5	88	24	.	.	.
cord-346853-0c1qdjb5	89	1	Whether	whether	IN
cord-346853-0c1qdjb5	89	2	similar	similar	JJ
cord-346853-0c1qdjb5	89	3	constraints	constraint	NNS
cord-346853-0c1qdjb5	89	4	apply	apply	VBP
cord-346853-0c1qdjb5	89	5	to	to	IN
cord-346853-0c1qdjb5	89	6	viruses	virus	NNS
cord-346853-0c1qdjb5	89	7	transmitted	transmit	VBN
cord-346853-0c1qdjb5	89	8	by	by	IN
cord-346853-0c1qdjb5	89	9	other	other	JJ
cord-346853-0c1qdjb5	89	10	mechanisms	mechanism	NNS
cord-346853-0c1qdjb5	89	11	is	be	VBZ
cord-346853-0c1qdjb5	89	12	unknown	unknown	JJ
cord-346853-0c1qdjb5	89	13	.	.	.
cord-346853-0c1qdjb5	90	1	Central	central	JJ
cord-346853-0c1qdjb5	90	2	to	to	IN
cord-346853-0c1qdjb5	90	3	our	-PRON-	PRP$
cord-346853-0c1qdjb5	90	4	discussion	discussion	NN
cord-346853-0c1qdjb5	90	5	so	so	RB
cord-346853-0c1qdjb5	90	6	far	far	RB
cord-346853-0c1qdjb5	90	7	has	have	VBZ
cord-346853-0c1qdjb5	90	8	been	be	VBN
cord-346853-0c1qdjb5	90	9	the	the	DT
cord-346853-0c1qdjb5	90	10	assumption	assumption	NN
cord-346853-0c1qdjb5	90	11	that	that	IN
cord-346853-0c1qdjb5	90	12	nearly	nearly	RB
cord-346853-0c1qdjb5	90	13	all	all	DT
cord-346853-0c1qdjb5	90	14	emerging	emerge	VBG
cord-346853-0c1qdjb5	90	15	viruses	virus	NNS
cord-346853-0c1qdjb5	90	16	have	have	VBP
cord-346853-0c1qdjb5	90	17	jumped	jump	VBN
cord-346853-0c1qdjb5	90	18	to	to	IN
cord-346853-0c1qdjb5	90	19	humans	human	NNS
cord-346853-0c1qdjb5	90	20	from	from	IN
cord-346853-0c1qdjb5	90	21	another	another	DT
cord-346853-0c1qdjb5	90	22	animal	animal	NN
cord-346853-0c1qdjb5	90	23	species	specie	NNS
cord-346853-0c1qdjb5	90	24	,	,	,
cord-346853-0c1qdjb5	90	25	in	in	IN
cord-346853-0c1qdjb5	90	26	a	a	DT
cord-346853-0c1qdjb5	90	27	process	process	NN
cord-346853-0c1qdjb5	90	28	of	of	IN
cord-346853-0c1qdjb5	90	29	cross	cross	JJ
cord-346853-0c1qdjb5	90	30	-	-	JJ
cord-346853-0c1qdjb5	90	31	species	species	JJ
cord-346853-0c1qdjb5	90	32	transmission	transmission	NN
cord-346853-0c1qdjb5	90	33	.	.	.
cord-346853-0c1qdjb5	91	1	Indeed	indeed	RB
cord-346853-0c1qdjb5	91	2	,	,	,
cord-346853-0c1qdjb5	91	3	one	one	CD
cord-346853-0c1qdjb5	91	4	of	of	IN
cord-346853-0c1qdjb5	91	5	the	the	DT
cord-346853-0c1qdjb5	91	6	great	great	JJ
cord-346853-0c1qdjb5	91	7	successes	success	NNS
cord-346853-0c1qdjb5	91	8	of	of	IN
cord-346853-0c1qdjb5	91	9	molecular	molecular	JJ
cord-346853-0c1qdjb5	91	10	epidemiology	epidemiology	NN
cord-346853-0c1qdjb5	91	11	has	have	VBZ
cord-346853-0c1qdjb5	91	12	been	be	VBN
cord-346853-0c1qdjb5	91	13	the	the	DT
cord-346853-0c1qdjb5	91	14	identification	identification	NN
cord-346853-0c1qdjb5	91	15	,	,	,
cord-346853-0c1qdjb5	91	16	often	often	RB
cord-346853-0c1qdjb5	91	17	very	very	RB
cord-346853-0c1qdjb5	91	18	rapidly	rapidly	RB
cord-346853-0c1qdjb5	91	19	,	,	,
cord-346853-0c1qdjb5	91	20	of	of	IN
cord-346853-0c1qdjb5	91	21	the	the	DT
cord-346853-0c1qdjb5	91	22	reservoir	reservoir	NN
cord-346853-0c1qdjb5	91	23	species	specie	NNS
cord-346853-0c1qdjb5	91	24	for	for	IN
cord-346853-0c1qdjb5	91	25	a	a	DT
cord-346853-0c1qdjb5	91	26	myriad	myriad	NN
cord-346853-0c1qdjb5	91	27	of	of	IN
cord-346853-0c1qdjb5	91	28	human	human	JJ
cord-346853-0c1qdjb5	91	29	viruses	virus	NNS
cord-346853-0c1qdjb5	91	30	.	.	.
cord-346853-0c1qdjb5	92	1	The	the	DT
cord-346853-0c1qdjb5	92	2	rapid	rapid	JJ
cord-346853-0c1qdjb5	92	3	discoveries	discovery	NNS
cord-346853-0c1qdjb5	92	4	of	of	IN
cord-346853-0c1qdjb5	92	5	the	the	DT
cord-346853-0c1qdjb5	92	6	nonhuman	nonhuman	NN
cord-346853-0c1qdjb5	92	7	primate	primate	JJ
cord-346853-0c1qdjb5	92	8	ancestry	ancestry	NN
cord-346853-0c1qdjb5	92	9	of	of	IN
cord-346853-0c1qdjb5	92	10	the	the	DT
cord-346853-0c1qdjb5	92	11	human	human	JJ
cord-346853-0c1qdjb5	92	12	immunodeficiency	immunodeficiency	NN
cord-346853-0c1qdjb5	92	13	virus	virus	NN
cord-346853-0c1qdjb5	92	14	(	(	-LRB-
cord-346853-0c1qdjb5	92	15	HIV	HIV	NNP
cord-346853-0c1qdjb5	92	16	)	)	-RRB-
cord-346853-0c1qdjb5	92	17	(	(	-LRB-
cord-346853-0c1qdjb5	92	18	Huet	Huet	NNP
cord-346853-0c1qdjb5	92	19	et	et	NNP
cord-346853-0c1qdjb5	92	20	al	al	NNP
cord-346853-0c1qdjb5	92	21	.	.	NNP
cord-346853-0c1qdjb5	92	22	1990	1990	CD
cord-346853-0c1qdjb5	92	23	)	)	-RRB-
cord-346853-0c1qdjb5	92	24	,	,	,
cord-346853-0c1qdjb5	92	25	and	and	CC
cord-346853-0c1qdjb5	92	26	of	of	IN
cord-346853-0c1qdjb5	92	27	some	some	DT
cord-346853-0c1qdjb5	92	28	bat	bat	NN
cord-346853-0c1qdjb5	92	29	species	specie	NNS
cord-346853-0c1qdjb5	92	30	as	as	IN
cord-346853-0c1qdjb5	92	31	the	the	DT
cord-346853-0c1qdjb5	92	32	ultimate	ultimate	JJ
cord-346853-0c1qdjb5	92	33	reservoir	reservoir	NN
cord-346853-0c1qdjb5	92	34	of	of	IN
cord-346853-0c1qdjb5	92	35	SARS	SARS	NNP
cord-346853-0c1qdjb5	92	36	coronavirus	coronavirus	NN
cord-346853-0c1qdjb5	92	37	(	(	-LRB-
cord-346853-0c1qdjb5	92	38	SARS	SARS	NNP
cord-346853-0c1qdjb5	92	39	-	-	HYPH
cord-346853-0c1qdjb5	92	40	CoV	CoV	NNP
cord-346853-0c1qdjb5	92	41	)	)	-RRB-
cord-346853-0c1qdjb5	92	42	(	(	-LRB-
cord-346853-0c1qdjb5	92	43	Lau	Lau	NNP
cord-346853-0c1qdjb5	92	44	et	et	NNP
cord-346853-0c1qdjb5	92	45	al	al	NNP
cord-346853-0c1qdjb5	92	46	.	.	NNP
cord-346853-0c1qdjb5	92	47	2005	2005	CD
cord-346853-0c1qdjb5	92	48	;	;	:
cord-346853-0c1qdjb5	92	49	Li	Li	NNP
cord-346853-0c1qdjb5	92	50	et	et	NNP
cord-346853-0c1qdjb5	92	51	al	al	NNP
cord-346853-0c1qdjb5	92	52	.	.	NNP
cord-346853-0c1qdjb5	92	53	2005	2005	CD
cord-346853-0c1qdjb5	92	54	)	)	-RRB-
cord-346853-0c1qdjb5	92	55	,	,	,
cord-346853-0c1qdjb5	92	56	serve	serve	VBP
cord-346853-0c1qdjb5	92	57	as	as	IN
cord-346853-0c1qdjb5	92	58	important	important	JJ
cord-346853-0c1qdjb5	92	59	illustrations	illustration	NNS
cord-346853-0c1qdjb5	92	60	.	.	.
cord-346853-0c1qdjb5	93	1	However	however	RB
cord-346853-0c1qdjb5	93	2	,	,	,
cord-346853-0c1qdjb5	93	3	there	there	EX
cord-346853-0c1qdjb5	93	4	are	be	VBP
cord-346853-0c1qdjb5	93	5	exceptions	exception	NNS
cord-346853-0c1qdjb5	93	6	.	.	.
cord-346853-0c1qdjb5	94	1	Perhaps	perhaps	RB
cord-346853-0c1qdjb5	94	2	the	the	DT
cord-346853-0c1qdjb5	94	3	most	most	RBS
cord-346853-0c1qdjb5	94	4	notable	notable	JJ
cord-346853-0c1qdjb5	94	5	are	be	VBP
cord-346853-0c1qdjb5	94	6	the	the	DT
cord-346853-0c1qdjb5	94	7	Ebola	Ebola	NNP
cord-346853-0c1qdjb5	94	8	virus	virus	NN
cord-346853-0c1qdjb5	94	9	,	,	,
cord-346853-0c1qdjb5	94	10	where	where	WRB
cord-346853-0c1qdjb5	94	11	many	many	JJ
cord-346853-0c1qdjb5	94	12	thousands	thousand	NNS
cord-346853-0c1qdjb5	94	13	of	of	IN
cord-346853-0c1qdjb5	94	14	animal	animal	NN
cord-346853-0c1qdjb5	94	15	specimens	specimen	NNS
cord-346853-0c1qdjb5	94	16	have	have	VBP
cord-346853-0c1qdjb5	94	17	been	be	VBN
cord-346853-0c1qdjb5	94	18	surveyed	survey	VBN
cord-346853-0c1qdjb5	94	19	in	in	IN
cord-346853-0c1qdjb5	94	20	Africa	Africa	NNP
cord-346853-0c1qdjb5	94	21	without	without	IN
cord-346853-0c1qdjb5	94	22	certain	certain	JJ
cord-346853-0c1qdjb5	94	23	identification	identification	NN
cord-346853-0c1qdjb5	94	24	of	of	IN
cord-346853-0c1qdjb5	94	25	the	the	DT
cord-346853-0c1qdjb5	94	26	reservoir	reservoir	NN
cord-346853-0c1qdjb5	94	27	species	specie	NNS
cord-346853-0c1qdjb5	94	28	(	(	-LRB-
cord-346853-0c1qdjb5	94	29	Breman	Breman	NNP
cord-346853-0c1qdjb5	94	30	et	et	NNP
cord-346853-0c1qdjb5	94	31	al	al	NNP
cord-346853-0c1qdjb5	94	32	.	.	.
cord-346853-0c1qdjb5	94	33	1999	1999	CD
cord-346853-0c1qdjb5	94	34	;	;	:
cord-346853-0c1qdjb5	94	35	Peterson	Peterson	NNP
cord-346853-0c1qdjb5	94	36	et	et	NNP
cord-346853-0c1qdjb5	94	37	al	al	NNP
cord-346853-0c1qdjb5	94	38	.	.	.
cord-346853-0c1qdjb5	94	39	2004	2004	CD
cord-346853-0c1qdjb5	94	40	)	)	-RRB-
cord-346853-0c1qdjb5	94	41	,	,	,
cord-346853-0c1qdjb5	94	42	although	although	IN
cord-346853-0c1qdjb5	94	43	bats	bat	NNS
cord-346853-0c1qdjb5	94	44	have	have	VBP
cord-346853-0c1qdjb5	94	45	been	be	VBN
cord-346853-0c1qdjb5	94	46	recently	recently	RB
cord-346853-0c1qdjb5	94	47	implicated	implicate	VBN
cord-346853-0c1qdjb5	94	48	(	(	-LRB-
cord-346853-0c1qdjb5	94	49	see	see	VB
cord-346853-0c1qdjb5	94	50	the	the	DT
cord-346853-0c1qdjb5	94	51	chapter	chapter	NN
cord-346853-0c1qdjb5	94	52	by	by	IN
cord-346853-0c1qdjb5	94	53	Gonzalez	Gonzalez	NNP
cord-346853-0c1qdjb5	94	54	et	et	NNP
cord-346853-0c1qdjb5	94	55	al	al	NNP
cord-346853-0c1qdjb5	94	56	.	.	NNP
cord-346853-0c1qdjb5	94	57	,	,	,
cord-346853-0c1qdjb5	94	58	this	this	DT
cord-346853-0c1qdjb5	94	59	volume	volume	NN
cord-346853-0c1qdjb5	94	60	)	)	-RRB-
cord-346853-0c1qdjb5	94	61	and	and	CC
cord-346853-0c1qdjb5	94	62	hepatitis	hepatitis	NNP
cord-346853-0c1qdjb5	94	63	C	C	NNP
cord-346853-0c1qdjb5	94	64	virus	virus	NN
cord-346853-0c1qdjb5	94	65	,	,	,
cord-346853-0c1qdjb5	94	66	cause	cause	NN
cord-346853-0c1qdjb5	94	67	of	of	IN
cord-346853-0c1qdjb5	94	68	one	one	CD
cord-346853-0c1qdjb5	94	69	of	of	IN
cord-346853-0c1qdjb5	94	70	the	the	DT
cord-346853-0c1qdjb5	94	71	most	most	RBS
cord-346853-0c1qdjb5	94	72	prevalent	prevalent	JJ
cord-346853-0c1qdjb5	94	73	somewhat	somewhat	RB
cord-346853-0c1qdjb5	94	74	new	new	JJ
cord-346853-0c1qdjb5	94	75	diseases	disease	NNS
cord-346853-0c1qdjb5	94	76	to	to	TO
cord-346853-0c1qdjb5	94	77	be	be	VB
cord-346853-0c1qdjb5	94	78	identified	identify	VBN
cord-346853-0c1qdjb5	94	79	in	in	IN
cord-346853-0c1qdjb5	94	80	humans	human	NNS
cord-346853-0c1qdjb5	94	81	but	but	CC
cord-346853-0c1qdjb5	94	82	where	where	WRB
cord-346853-0c1qdjb5	94	83	no	no	DT
cord-346853-0c1qdjb5	94	84	close	close	JJ
cord-346853-0c1qdjb5	94	85	relatives	relative	NNS
cord-346853-0c1qdjb5	94	86	have	have	VBP
cord-346853-0c1qdjb5	94	87	been	be	VBN
cord-346853-0c1qdjb5	94	88	discovered	discover	VBN
cord-346853-0c1qdjb5	94	89	(	(	-LRB-
cord-346853-0c1qdjb5	94	90	Simmonds	Simmonds	NNP
cord-346853-0c1qdjb5	94	91	2004	2004	CD
cord-346853-0c1qdjb5	94	92	)	)	-RRB-
cord-346853-0c1qdjb5	94	93	.	.	.
cord-346853-0c1qdjb5	95	1	However	however	RB
cord-346853-0c1qdjb5	95	2	,	,	,
cord-346853-0c1qdjb5	95	3	it	-PRON-	PRP
cord-346853-0c1qdjb5	95	4	is	be	VBZ
cord-346853-0c1qdjb5	95	5	likely	likely	JJ
cord-346853-0c1qdjb5	95	6	that	that	IN
cord-346853-0c1qdjb5	95	7	with	with	IN
cord-346853-0c1qdjb5	95	8	an	an	DT
cord-346853-0c1qdjb5	95	9	increased	increase	VBN
cord-346853-0c1qdjb5	95	10	sampling	sampling	NN
cord-346853-0c1qdjb5	95	11	of	of	IN
cord-346853-0c1qdjb5	95	12	taxa	taxon	NNS
cord-346853-0c1qdjb5	95	13	the	the	DT
cord-346853-0c1qdjb5	95	14	species	specie	NNS
cord-346853-0c1qdjb5	95	15	reservoirs	reservoir	NNS
cord-346853-0c1qdjb5	95	16	for	for	IN
cord-346853-0c1qdjb5	95	17	these	these	DT
cord-346853-0c1qdjb5	95	18	viruses	virus	NNS
cord-346853-0c1qdjb5	95	19	will	will	MD
cord-346853-0c1qdjb5	95	20	also	also	RB
cord-346853-0c1qdjb5	95	21	be	be	VB
cord-346853-0c1qdjb5	95	22	determined	determine	VBN
cord-346853-0c1qdjb5	95	23	,	,	,
cord-346853-0c1qdjb5	95	24	if	if	IN
cord-346853-0c1qdjb5	95	25	they	-PRON-	PRP
cord-346853-0c1qdjb5	95	26	still	still	RB
cord-346853-0c1qdjb5	95	27	exist	exist	VBP
cord-346853-0c1qdjb5	95	28	today	today	NN
cord-346853-0c1qdjb5	95	29	.	.	.
cord-346853-0c1qdjb5	96	1	The	the	DT
cord-346853-0c1qdjb5	96	2	next	next	JJ
cord-346853-0c1qdjb5	96	3	question	question	NN
cord-346853-0c1qdjb5	96	4	that	that	WDT
cord-346853-0c1qdjb5	96	5	arises	arise	VBZ
cord-346853-0c1qdjb5	96	6	is	be	VBZ
cord-346853-0c1qdjb5	96	7	whether	whether	IN
cord-346853-0c1qdjb5	96	8	some	some	DT
cord-346853-0c1qdjb5	96	9	viruses	virus	NNS
cord-346853-0c1qdjb5	96	10	are	be	VBP
cord-346853-0c1qdjb5	96	11	more	more	RBR
cord-346853-0c1qdjb5	96	12	able	able	JJ
cord-346853-0c1qdjb5	96	13	to	to	TO
cord-346853-0c1qdjb5	96	14	jump	jump	VB
cord-346853-0c1qdjb5	96	15	species	species	NN
cord-346853-0c1qdjb5	96	16	boundaries	boundary	NNS
cord-346853-0c1qdjb5	96	17	than	than	IN
cord-346853-0c1qdjb5	96	18	others	other	NNS
cord-346853-0c1qdjb5	96	19	.	.	.
cord-346853-0c1qdjb5	97	1	The	the	DT
cord-346853-0c1qdjb5	97	2	most	most	RBS
cord-346853-0c1qdjb5	97	3	compelling	compelling	JJ
cord-346853-0c1qdjb5	97	4	idea	idea	NN
cord-346853-0c1qdjb5	97	5	in	in	IN
cord-346853-0c1qdjb5	97	6	this	this	DT
cord-346853-0c1qdjb5	97	7	context	context	NN
cord-346853-0c1qdjb5	97	8	is	be	VBZ
cord-346853-0c1qdjb5	97	9	that	that	IN
cord-346853-0c1qdjb5	97	10	there	there	EX
cord-346853-0c1qdjb5	97	11	are	be	VBP
cord-346853-0c1qdjb5	97	12	phylogenetic	phylogenetic	JJ
cord-346853-0c1qdjb5	97	13	constraints	constraint	NNS
cord-346853-0c1qdjb5	97	14	to	to	IN
cord-346853-0c1qdjb5	97	15	this	this	DT
cord-346853-0c1qdjb5	97	16	process	process	NN
cord-346853-0c1qdjb5	97	17	,	,	,
cord-346853-0c1qdjb5	97	18	such	such	JJ
cord-346853-0c1qdjb5	97	19	that	that	IN
cord-346853-0c1qdjb5	97	20	the	the	DT
cord-346853-0c1qdjb5	97	21	more	more	RBR
cord-346853-0c1qdjb5	97	22	closely	closely	RB
cord-346853-0c1qdjb5	97	23	related	relate	VBN
cord-346853-0c1qdjb5	97	24	the	the	DT
cord-346853-0c1qdjb5	97	25	host	host	NN
cord-346853-0c1qdjb5	97	26	species	species	NN
cord-346853-0c1qdjb5	97	27	in	in	IN
cord-346853-0c1qdjb5	97	28	question	question	NN
cord-346853-0c1qdjb5	97	29	,	,	,
cord-346853-0c1qdjb5	97	30	the	the	DT
cord-346853-0c1qdjb5	97	31	greater	great	JJR
cord-346853-0c1qdjb5	97	32	the	the	DT
cord-346853-0c1qdjb5	97	33	chance	chance	NN
cord-346853-0c1qdjb5	97	34	of	of	IN
cord-346853-0c1qdjb5	97	35	successful	successful	JJ
cord-346853-0c1qdjb5	97	36	crossspecies	crossspecie	NNS
cord-346853-0c1qdjb5	97	37	transmission	transmission	NN
cord-346853-0c1qdjb5	97	38	(	(	-LRB-
cord-346853-0c1qdjb5	97	39	DeFilippis	DeFilippis	NNP
cord-346853-0c1qdjb5	97	40	and	and	CC
cord-346853-0c1qdjb5	97	41	Villarreal	Villarreal	NNP
cord-346853-0c1qdjb5	97	42	2000	2000	CD
cord-346853-0c1qdjb5	97	43	)	)	-RRB-
cord-346853-0c1qdjb5	97	44	.	.	.
cord-346853-0c1qdjb5	98	1	This	this	DT
cord-346853-0c1qdjb5	98	2	theory	theory	NN
cord-346853-0c1qdjb5	98	3	is	be	VBZ
cord-346853-0c1qdjb5	98	4	supported	support	VBN
cord-346853-0c1qdjb5	98	5	by	by	IN
cord-346853-0c1qdjb5	98	6	some	some	DT
cord-346853-0c1qdjb5	98	7	broad	broad	JJ
cord-346853-0c1qdjb5	98	8	-	-	HYPH
cord-346853-0c1qdjb5	98	9	brush	brush	NN
cord-346853-0c1qdjb5	98	10	observations	observation	NNS
cord-346853-0c1qdjb5	98	11	.	.	.
cord-346853-0c1qdjb5	99	1	In	in	IN
cord-346853-0c1qdjb5	99	2	particular	particular	JJ
cord-346853-0c1qdjb5	99	3	,	,	,
cord-346853-0c1qdjb5	99	4	there	there	EX
cord-346853-0c1qdjb5	99	5	is	be	VBZ
cord-346853-0c1qdjb5	99	6	no	no	DT
cord-346853-0c1qdjb5	99	7	evidence	evidence	NN
cord-346853-0c1qdjb5	99	8	that	that	IN
cord-346853-0c1qdjb5	99	9	the	the	DT
cord-346853-0c1qdjb5	99	10	viruses	virus	NNS
cord-346853-0c1qdjb5	99	11	that	that	WDT
cord-346853-0c1qdjb5	99	12	infect	infect	VBP
cord-346853-0c1qdjb5	99	13	humans	human	NNS
cord-346853-0c1qdjb5	99	14	come	come	VBP
cord-346853-0c1qdjb5	99	15	from	from	IN
cord-346853-0c1qdjb5	99	16	organisms	organism	NNS
cord-346853-0c1qdjb5	99	17	as	as	RB
cord-346853-0c1qdjb5	99	18	divergent	divergent	JJ
cord-346853-0c1qdjb5	99	19	as	as	IN
cord-346853-0c1qdjb5	99	20	plants	plant	NNS
cord-346853-0c1qdjb5	99	21	,	,	,
cord-346853-0c1qdjb5	99	22	fish	fish	NN
cord-346853-0c1qdjb5	99	23	,	,	,
cord-346853-0c1qdjb5	99	24	reptiles	reptile	NNS
cord-346853-0c1qdjb5	99	25	,	,	,
cord-346853-0c1qdjb5	99	26	or	or	CC
cord-346853-0c1qdjb5	99	27	amphibians	amphibian	NNS
cord-346853-0c1qdjb5	99	28	(	(	-LRB-
cord-346853-0c1qdjb5	99	29	Holmes	Holmes	NNP
cord-346853-0c1qdjb5	99	30	and	and	CC
cord-346853-0c1qdjb5	99	31	Rambaut	Rambaut	NNP
cord-346853-0c1qdjb5	99	32	2004	2004	CD
cord-346853-0c1qdjb5	99	33	)	)	-RRB-
cord-346853-0c1qdjb5	99	34	,	,	,
cord-346853-0c1qdjb5	99	35	even	even	RB
cord-346853-0c1qdjb5	99	36	though	though	IN
cord-346853-0c1qdjb5	99	37	in	in	IN
cord-346853-0c1qdjb5	99	38	some	some	DT
cord-346853-0c1qdjb5	99	39	cases	case	NNS
cord-346853-0c1qdjb5	99	40	,	,	,
cord-346853-0c1qdjb5	99	41	such	such	JJ
cord-346853-0c1qdjb5	99	42	as	as	IN
cord-346853-0c1qdjb5	99	43	plant	plant	NN
cord-346853-0c1qdjb5	99	44	viruses	virus	NNS
cord-346853-0c1qdjb5	99	45	,	,	,
cord-346853-0c1qdjb5	99	46	exposure	exposure	NN
cord-346853-0c1qdjb5	99	47	might	may	MD
cord-346853-0c1qdjb5	99	48	occur	occur	VB
cord-346853-0c1qdjb5	99	49	on	on	IN
cord-346853-0c1qdjb5	99	50	a	a	DT
cord-346853-0c1qdjb5	99	51	regular	regular	JJ
cord-346853-0c1qdjb5	99	52	basis	basis	NN
cord-346853-0c1qdjb5	99	53	through	through	IN
cord-346853-0c1qdjb5	99	54	the	the	DT
cord-346853-0c1qdjb5	99	55	consumption	consumption	NN
cord-346853-0c1qdjb5	99	56	of	of	IN
cord-346853-0c1qdjb5	99	57	infected	infect	VBN
cord-346853-0c1qdjb5	99	58	food	food	NN
cord-346853-0c1qdjb5	99	59	.	.	.
cord-346853-0c1qdjb5	100	1	Rather	rather	RB
cord-346853-0c1qdjb5	100	2	,	,	,
cord-346853-0c1qdjb5	100	3	the	the	DT
cord-346853-0c1qdjb5	100	4	majority	majority	NN
cord-346853-0c1qdjb5	100	5	of	of	IN
cord-346853-0c1qdjb5	100	6	human	human	JJ
cord-346853-0c1qdjb5	100	7	viruses	virus	NNS
cord-346853-0c1qdjb5	100	8	are	be	VBP
cord-346853-0c1qdjb5	100	9	of	of	IN
cord-346853-0c1qdjb5	100	10	mammalian	mammalian	JJ
cord-346853-0c1qdjb5	100	11	origin	origin	NN
cord-346853-0c1qdjb5	100	12	,	,	,
cord-346853-0c1qdjb5	100	13	with	with	IN
cord-346853-0c1qdjb5	100	14	an	an	DT
cord-346853-0c1qdjb5	100	15	occasional	occasional	JJ
cord-346853-0c1qdjb5	100	16	few	few	JJ
cord-346853-0c1qdjb5	100	17	coming	come	VBG
cord-346853-0c1qdjb5	100	18	from	from	IN
cord-346853-0c1qdjb5	100	19	birds	bird	NNS
cord-346853-0c1qdjb5	100	20	.	.	.
cord-346853-0c1qdjb5	101	1	Moreover	moreover	RB
cord-346853-0c1qdjb5	101	2	,	,	,
cord-346853-0c1qdjb5	101	3	although	although	IN
cord-346853-0c1qdjb5	101	4	insect	insect	NN
cord-346853-0c1qdjb5	101	5	viruses	virus	NNS
cord-346853-0c1qdjb5	101	6	often	often	RB
cord-346853-0c1qdjb5	101	7	infect	infect	VBP
cord-346853-0c1qdjb5	101	8	human	human	JJ
cord-346853-0c1qdjb5	101	9	populations	population	NNS
cord-346853-0c1qdjb5	101	10	(	(	-LRB-
cord-346853-0c1qdjb5	101	11	that	that	RB
cord-346853-0c1qdjb5	101	12	is	is	RB
cord-346853-0c1qdjb5	101	13	,	,	,
cord-346853-0c1qdjb5	101	14	the	the	DT
cord-346853-0c1qdjb5	101	15	arboviruses	arboviruses	NNP
cord-346853-0c1qdjb5	101	16	)	)	-RRB-
cord-346853-0c1qdjb5	101	17	,	,	,
cord-346853-0c1qdjb5	101	18	these	these	DT
cord-346853-0c1qdjb5	101	19	always	always	RB
cord-346853-0c1qdjb5	101	20	jump	jump	VBP
cord-346853-0c1qdjb5	101	21	from	from	IN
cord-346853-0c1qdjb5	101	22	another	another	DT
cord-346853-0c1qdjb5	101	23	mammalian	mammalian	JJ
cord-346853-0c1qdjb5	101	24	species	specie	NNS
cord-346853-0c1qdjb5	101	25	rather	rather	RB
cord-346853-0c1qdjb5	101	26	than	than	IN
cord-346853-0c1qdjb5	101	27	directly	directly	RB
cord-346853-0c1qdjb5	101	28	from	from	IN
cord-346853-0c1qdjb5	101	29	insects	insect	NNS
cord-346853-0c1qdjb5	101	30	and	and	CC
cord-346853-0c1qdjb5	101	31	,	,	,
cord-346853-0c1qdjb5	101	32	as	as	IN
cord-346853-0c1qdjb5	101	33	described	describe	VBN
cord-346853-0c1qdjb5	101	34	above	above	RB
cord-346853-0c1qdjb5	101	35	,	,	,
cord-346853-0c1qdjb5	101	36	tend	tend	VBP
cord-346853-0c1qdjb5	101	37	to	to	TO
cord-346853-0c1qdjb5	101	38	cause	cause	VB
cord-346853-0c1qdjb5	101	39	dead	dead	JJ
cord-346853-0c1qdjb5	101	40	-	-	HYPH
cord-346853-0c1qdjb5	101	41	end	end	NN
cord-346853-0c1qdjb5	101	42	infections	infection	NNS
cord-346853-0c1qdjb5	101	43	in	in	IN
cord-346853-0c1qdjb5	101	44	new	new	JJ
cord-346853-0c1qdjb5	101	45	hosts	host	NNS
cord-346853-0c1qdjb5	101	46	(	(	-LRB-
cord-346853-0c1qdjb5	101	47	see	see	VB
cord-346853-0c1qdjb5	101	48	the	the	DT
cord-346853-0c1qdjb5	101	49	chapter	chapter	NN
cord-346853-0c1qdjb5	101	50	by	by	IN
cord-346853-0c1qdjb5	101	51	Nel	Nel	NNP
cord-346853-0c1qdjb5	101	52	and	and	CC
cord-346853-0c1qdjb5	101	53	Rupprecht	Rupprecht	NNP
cord-346853-0c1qdjb5	101	54	,	,	,
cord-346853-0c1qdjb5	101	55	this	this	DT
cord-346853-0c1qdjb5	101	56	volume	volume	NN
cord-346853-0c1qdjb5	101	57	,	,	,
cord-346853-0c1qdjb5	101	58	for	for	IN
cord-346853-0c1qdjb5	101	59	discussion	discussion	NN
cord-346853-0c1qdjb5	101	60	of	of	IN
cord-346853-0c1qdjb5	101	61	the	the	DT
cord-346853-0c1qdjb5	101	62	origin	origin	NN
cord-346853-0c1qdjb5	101	63	of	of	IN
cord-346853-0c1qdjb5	101	64	rhabdoviruses	rhabdovirus	NNS
cord-346853-0c1qdjb5	101	65	infecting	infect	VBG
cord-346853-0c1qdjb5	101	66	mammals	mammal	NNS
cord-346853-0c1qdjb5	101	67	from	from	IN
cord-346853-0c1qdjb5	101	68	a	a	DT
cord-346853-0c1qdjb5	101	69	potential	potential	JJ
cord-346853-0c1qdjb5	101	70	insect	insect	NN
cord-346853-0c1qdjb5	101	71	source	source	NN
cord-346853-0c1qdjb5	101	72	)	)	-RRB-
cord-346853-0c1qdjb5	101	73	.	.	.
cord-346853-0c1qdjb5	102	1	A	a	DT
cord-346853-0c1qdjb5	102	2	more	more	RBR
cord-346853-0c1qdjb5	102	3	revealing	revealing	JJ
cord-346853-0c1qdjb5	102	4	question	question	NN
cord-346853-0c1qdjb5	102	5	is	be	VBZ
cord-346853-0c1qdjb5	102	6	whether	whether	IN
cord-346853-0c1qdjb5	102	7	there	there	EX
cord-346853-0c1qdjb5	102	8	are	be	VBP
cord-346853-0c1qdjb5	102	9	any	any	DT
cord-346853-0c1qdjb5	102	10	phylogenetic	phylogenetic	JJ
cord-346853-0c1qdjb5	102	11	trends	trend	NNS
cord-346853-0c1qdjb5	102	12	with	with	IN
cord-346853-0c1qdjb5	102	13	respect	respect	NN
cord-346853-0c1qdjb5	102	14	to	to	IN
cord-346853-0c1qdjb5	102	15	the	the	DT
cord-346853-0c1qdjb5	102	16	mammalian	mammalian	JJ
cord-346853-0c1qdjb5	102	17	viruses	virus	NNS
cord-346853-0c1qdjb5	102	18	that	that	WDT
cord-346853-0c1qdjb5	102	19	also	also	RB
cord-346853-0c1qdjb5	102	20	affect	affect	VBP
cord-346853-0c1qdjb5	102	21	humans	human	NNS
cord-346853-0c1qdjb5	102	22	.	.	.
cord-346853-0c1qdjb5	103	1	Specifically	specifically	RB
cord-346853-0c1qdjb5	103	2	,	,	,
cord-346853-0c1qdjb5	103	3	are	be	VBP
cord-346853-0c1qdjb5	103	4	those	those	DT
cord-346853-0c1qdjb5	103	5	viruses	virus	NNS
cord-346853-0c1qdjb5	103	6	from	from	IN
cord-346853-0c1qdjb5	103	7	our	-PRON-	PRP$
cord-346853-0c1qdjb5	103	8	closest	close	JJS
cord-346853-0c1qdjb5	103	9	relatives	relative	NNS
cord-346853-0c1qdjb5	103	10	,	,	,
cord-346853-0c1qdjb5	103	11	the	the	DT
cord-346853-0c1qdjb5	103	12	simian	simian	JJ
cord-346853-0c1qdjb5	103	13	primates	primate	NNS
cord-346853-0c1qdjb5	103	14	,	,	,
cord-346853-0c1qdjb5	103	15	more	more	RBR
cord-346853-0c1qdjb5	103	16	able	able	JJ
cord-346853-0c1qdjb5	103	17	to	to	TO
cord-346853-0c1qdjb5	103	18	infect	infect	VB
cord-346853-0c1qdjb5	103	19	us	-PRON-	PRP
cord-346853-0c1qdjb5	103	20	than	than	IN
cord-346853-0c1qdjb5	103	21	those	those	DT
cord-346853-0c1qdjb5	103	22	from	from	IN
cord-346853-0c1qdjb5	103	23	other	other	JJ
cord-346853-0c1qdjb5	103	24	mammalian	mammalian	JJ
cord-346853-0c1qdjb5	103	25	orders	order	NNS
cord-346853-0c1qdjb5	103	26	?	?	.
cord-346853-0c1qdjb5	104	1	At	at	IN
cord-346853-0c1qdjb5	104	2	present	present	NN
cord-346853-0c1qdjb5	104	3	there	there	EX
cord-346853-0c1qdjb5	104	4	is	be	VBZ
cord-346853-0c1qdjb5	104	5	insufficient	insufficient	JJ
cord-346853-0c1qdjb5	104	6	data	datum	NNS
cord-346853-0c1qdjb5	104	7	to	to	TO
cord-346853-0c1qdjb5	104	8	fully	fully	RB
cord-346853-0c1qdjb5	104	9	test	test	VB
cord-346853-0c1qdjb5	104	10	this	this	DT
cord-346853-0c1qdjb5	104	11	hypothesis	hypothesis	NN
cord-346853-0c1qdjb5	104	12	,	,	,
cord-346853-0c1qdjb5	104	13	although	although	IN
cord-346853-0c1qdjb5	104	14	it	-PRON-	PRP
cord-346853-0c1qdjb5	104	15	is	be	VBZ
cord-346853-0c1qdjb5	104	16	clearly	clearly	RB
cord-346853-0c1qdjb5	104	17	a	a	DT
cord-346853-0c1qdjb5	104	18	research	research	NN
cord-346853-0c1qdjb5	104	19	priority	priority	NN
cord-346853-0c1qdjb5	104	20	for	for	IN
cord-346853-0c1qdjb5	104	21	the	the	DT
cord-346853-0c1qdjb5	104	22	future	future	NN
cord-346853-0c1qdjb5	104	23	.	.	.
cord-346853-0c1qdjb5	105	1	Additionally	additionally	RB
cord-346853-0c1qdjb5	105	2	,	,	,
cord-346853-0c1qdjb5	105	3	it	-PRON-	PRP
cord-346853-0c1qdjb5	105	4	is	be	VBZ
cord-346853-0c1qdjb5	105	5	difficult	difficult	JJ
cord-346853-0c1qdjb5	105	6	to	to	TO
cord-346853-0c1qdjb5	105	7	fully	fully	RB
cord-346853-0c1qdjb5	105	8	disentangle	disentangle	VB
cord-346853-0c1qdjb5	105	9	probability	probability	NN
cord-346853-0c1qdjb5	105	10	of	of	IN
cord-346853-0c1qdjb5	105	11	transmission	transmission	NN
cord-346853-0c1qdjb5	105	12	from	from	IN
cord-346853-0c1qdjb5	105	13	probability	probability	NN
cord-346853-0c1qdjb5	105	14	of	of	IN
cord-346853-0c1qdjb5	105	15	exposure	exposure	NN
cord-346853-0c1qdjb5	105	16	;	;	:
cord-346853-0c1qdjb5	105	17	for	for	IN
cord-346853-0c1qdjb5	105	18	example	example	NN
cord-346853-0c1qdjb5	105	19	,	,	,
cord-346853-0c1qdjb5	105	20	although	although	IN
cord-346853-0c1qdjb5	105	21	we	-PRON-	PRP
cord-346853-0c1qdjb5	105	22	are	be	VBP
cord-346853-0c1qdjb5	105	23	clearly	clearly	RB
cord-346853-0c1qdjb5	105	24	more	more	RBR
cord-346853-0c1qdjb5	105	25	closely	closely	RB
cord-346853-0c1qdjb5	105	26	related	relate	VBN
cord-346853-0c1qdjb5	105	27	to	to	IN
cord-346853-0c1qdjb5	105	28	other	other	JJ
cord-346853-0c1qdjb5	105	29	primates	primate	NNS
cord-346853-0c1qdjb5	105	30	than	than	IN
cord-346853-0c1qdjb5	105	31	to	to	IN
cord-346853-0c1qdjb5	105	32	rodents	rodent	NNS
cord-346853-0c1qdjb5	105	33	,	,	,
cord-346853-0c1qdjb5	105	34	the	the	DT
cord-346853-0c1qdjb5	105	35	global	global	JJ
cord-346853-0c1qdjb5	105	36	human	human	JJ
cord-346853-0c1qdjb5	105	37	population	population	NN
cord-346853-0c1qdjb5	105	38	is	be	VBZ
cord-346853-0c1qdjb5	105	39	more	more	RBR
cord-346853-0c1qdjb5	105	40	often	often	RB
cord-346853-0c1qdjb5	105	41	exposed	expose	VBN
cord-346853-0c1qdjb5	105	42	to	to	IN
cord-346853-0c1qdjb5	105	43	the	the	DT
cord-346853-0c1qdjb5	105	44	latter	latter	JJ
cord-346853-0c1qdjb5	105	45	.	.	.
cord-346853-0c1qdjb5	106	1	There	there	EX
cord-346853-0c1qdjb5	106	2	are	be	VBP
cord-346853-0c1qdjb5	106	3	,	,	,
cord-346853-0c1qdjb5	106	4	however	however	RB
cord-346853-0c1qdjb5	106	5	,	,	,
cord-346853-0c1qdjb5	106	6	some	some	DT
cord-346853-0c1qdjb5	106	7	tentative	tentative	JJ
cord-346853-0c1qdjb5	106	8	pieces	piece	NNS
cord-346853-0c1qdjb5	106	9	of	of	IN
cord-346853-0c1qdjb5	106	10	evidence	evidence	NN
cord-346853-0c1qdjb5	106	11	to	to	TO
cord-346853-0c1qdjb5	106	12	suggest	suggest	VB
cord-346853-0c1qdjb5	106	13	that	that	IN
cord-346853-0c1qdjb5	106	14	primate	primate	JJ
cord-346853-0c1qdjb5	106	15	viruses	virus	NNS
cord-346853-0c1qdjb5	106	16	are	be	VBP
cord-346853-0c1qdjb5	106	17	especially	especially	RB
cord-346853-0c1qdjb5	106	18	able	able	JJ
cord-346853-0c1qdjb5	106	19	to	to	TO
cord-346853-0c1qdjb5	106	20	infect	infect	VB
cord-346853-0c1qdjb5	106	21	us	-PRON-	PRP
cord-346853-0c1qdjb5	106	22	as	as	IN
cord-346853-0c1qdjb5	106	23	predicted	predict	VBN
cord-346853-0c1qdjb5	106	24	from	from	IN
cord-346853-0c1qdjb5	106	25	our	-PRON-	PRP$
cord-346853-0c1qdjb5	106	26	close	close	JJ
cord-346853-0c1qdjb5	106	27	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	106	28	relationship	relationship	NN
cord-346853-0c1qdjb5	106	29	.	.	.
cord-346853-0c1qdjb5	107	1	As	as	RB
cord-346853-0c1qdjb5	107	2	well	well	RB
cord-346853-0c1qdjb5	107	3	as	as	IN
cord-346853-0c1qdjb5	107	4	the	the	DT
cord-346853-0c1qdjb5	107	5	obvious	obvious	JJ
cord-346853-0c1qdjb5	107	6	cases	case	NNS
cord-346853-0c1qdjb5	107	7	of	of	IN
cord-346853-0c1qdjb5	107	8	HIV-1	HIV-1	NNP
cord-346853-0c1qdjb5	107	9	and	and	CC
cord-346853-0c1qdjb5	107	10	HIV-2	HIV-2	NNP
cord-346853-0c1qdjb5	107	11	,	,	,
cord-346853-0c1qdjb5	107	12	whose	whose	WP$
cord-346853-0c1qdjb5	107	13	ultimate	ultimate	JJ
cord-346853-0c1qdjb5	107	14	origins	origin	NNS
cord-346853-0c1qdjb5	107	15	lie	lie	VBP
cord-346853-0c1qdjb5	107	16	with	with	IN
cord-346853-0c1qdjb5	107	17	chimpanzees	chimpanzee	NNS
cord-346853-0c1qdjb5	107	18	(	(	-LRB-
cord-346853-0c1qdjb5	107	19	Pan	Pan	NNP
cord-346853-0c1qdjb5	107	20	troglodytes	troglodyte	NNS
cord-346853-0c1qdjb5	107	21	troglodytes	troglodyte	NNS
cord-346853-0c1qdjb5	107	22	)	)	-RRB-
cord-346853-0c1qdjb5	107	23	and	and	CC
cord-346853-0c1qdjb5	107	24	sooty	sooty	JJ
cord-346853-0c1qdjb5	107	25	mangabey	mangabey	NN
cord-346853-0c1qdjb5	107	26	monkeys	monkey	NNS
cord-346853-0c1qdjb5	107	27	(	(	-LRB-
cord-346853-0c1qdjb5	107	28	Cercocebus	Cercocebus	NNP
cord-346853-0c1qdjb5	107	29	torquatus	torquatus	FW
cord-346853-0c1qdjb5	107	30	atys	atys	NNP
cord-346853-0c1qdjb5	107	31	)	)	-RRB-
cord-346853-0c1qdjb5	107	32	,	,	,
cord-346853-0c1qdjb5	107	33	respectively	respectively	RB
cord-346853-0c1qdjb5	107	34	,	,	,
cord-346853-0c1qdjb5	107	35	a	a	DT
cord-346853-0c1qdjb5	107	36	variety	variety	NN
cord-346853-0c1qdjb5	107	37	of	of	IN
cord-346853-0c1qdjb5	107	38	other	other	JJ
cord-346853-0c1qdjb5	107	39	major	major	JJ
cord-346853-0c1qdjb5	107	40	human	human	JJ
cord-346853-0c1qdjb5	107	41	viruses	virus	NNS
cord-346853-0c1qdjb5	107	42	seem	seem	VBP
cord-346853-0c1qdjb5	107	43	to	to	TO
cord-346853-0c1qdjb5	107	44	have	have	VB
cord-346853-0c1qdjb5	107	45	their	-PRON-	PRP$
cord-346853-0c1qdjb5	107	46	origins	origin	NNS
cord-346853-0c1qdjb5	107	47	in	in	IN
cord-346853-0c1qdjb5	107	48	nonhuman	nonhuman	NN
cord-346853-0c1qdjb5	107	49	primates	primate	NNS
cord-346853-0c1qdjb5	107	50	.	.	.
cord-346853-0c1qdjb5	108	1	These	these	DT
cord-346853-0c1qdjb5	108	2	include	include	VBP
cord-346853-0c1qdjb5	108	3	dengue	dengue	NN
cord-346853-0c1qdjb5	108	4	virus	virus	NN
cord-346853-0c1qdjb5	108	5	,	,	,
cord-346853-0c1qdjb5	108	6	yellow	yellow	JJ
cord-346853-0c1qdjb5	108	7	fever	fever	NN
cord-346853-0c1qdjb5	108	8	virus	virus	NN
cord-346853-0c1qdjb5	108	9	,	,	,
cord-346853-0c1qdjb5	108	10	GB	GB	NNP
cord-346853-0c1qdjb5	108	11	viruses	viruse	VBZ
cord-346853-0c1qdjb5	108	12	A	A	NNP
cord-346853-0c1qdjb5	108	13	and	and	CC
cord-346853-0c1qdjb5	108	14	C	C	NNP
cord-346853-0c1qdjb5	108	15	,	,	,
cord-346853-0c1qdjb5	108	16	hepatitis	hepatitis	NN
cord-346853-0c1qdjb5	108	17	B	B	NNP
cord-346853-0c1qdjb5	108	18	virus	virus	NN
cord-346853-0c1qdjb5	108	19	,	,	,
cord-346853-0c1qdjb5	108	20	and	and	CC
cord-346853-0c1qdjb5	108	21	HTLV	HTLV	NNP
cord-346853-0c1qdjb5	108	22	-	-	HYPH
cord-346853-0c1qdjb5	108	23	I	I	NNP
cord-346853-0c1qdjb5	108	24	and	and	CC
cord-346853-0c1qdjb5	108	25	II	II	NNP
cord-346853-0c1qdjb5	108	26	.	.	.
cord-346853-0c1qdjb5	109	1	That	that	IN
cord-346853-0c1qdjb5	109	2	some	some	DT
cord-346853-0c1qdjb5	109	3	of	of	IN
cord-346853-0c1qdjb5	109	4	these	these	DT
cord-346853-0c1qdjb5	109	5	viruses	virus	NNS
cord-346853-0c1qdjb5	109	6	seem	seem	VBP
cord-346853-0c1qdjb5	109	7	to	to	TO
cord-346853-0c1qdjb5	109	8	have	have	VB
cord-346853-0c1qdjb5	109	9	appeared	appear	VBN
cord-346853-0c1qdjb5	109	10	relatively	relatively	RB
cord-346853-0c1qdjb5	109	11	recently	recently	RB
cord-346853-0c1qdjb5	109	12	in	in	IN
cord-346853-0c1qdjb5	109	13	humans	human	NNS
cord-346853-0c1qdjb5	109	14	may	may	MD
cord-346853-0c1qdjb5	109	15	be	be	VB
cord-346853-0c1qdjb5	109	16	a	a	DT
cord-346853-0c1qdjb5	109	17	consequence	consequence	NN
cord-346853-0c1qdjb5	109	18	of	of	IN
cord-346853-0c1qdjb5	109	19	changing	change	VBG
cord-346853-0c1qdjb5	109	20	ecological	ecological	JJ
cord-346853-0c1qdjb5	109	21	factors	factor	NNS
cord-346853-0c1qdjb5	109	22	,	,	,
cord-346853-0c1qdjb5	109	23	most	most	RBS
cord-346853-0c1qdjb5	109	24	notably	notably	RB
cord-346853-0c1qdjb5	109	25	deforestation	deforestation	NN
cord-346853-0c1qdjb5	109	26	and	and	CC
cord-346853-0c1qdjb5	109	27	linked	link	VBN
cord-346853-0c1qdjb5	109	28	activities	activity	NNS
cord-346853-0c1qdjb5	109	29	,	,	,
cord-346853-0c1qdjb5	109	30	that	that	WDT
cord-346853-0c1qdjb5	109	31	have	have	VBP
cord-346853-0c1qdjb5	109	32	increased	increase	VBN
cord-346853-0c1qdjb5	109	33	the	the	DT
cord-346853-0c1qdjb5	109	34	rate	rate	NN
cord-346853-0c1qdjb5	109	35	of	of	IN
cord-346853-0c1qdjb5	109	36	contact	contact	NN
cord-346853-0c1qdjb5	109	37	between	between	IN
cord-346853-0c1qdjb5	109	38	humans	human	NNS
cord-346853-0c1qdjb5	109	39	and	and	CC
cord-346853-0c1qdjb5	109	40	other	other	JJ
cord-346853-0c1qdjb5	109	41	primates	primate	NNS
cord-346853-0c1qdjb5	109	42	(	(	-LRB-
cord-346853-0c1qdjb5	109	43	although	although	IN
cord-346853-0c1qdjb5	109	44	an	an	DT
cord-346853-0c1qdjb5	109	45	absence	absence	NN
cord-346853-0c1qdjb5	109	46	of	of	IN
cord-346853-0c1qdjb5	109	47	retrospective	retrospective	JJ
cord-346853-0c1qdjb5	109	48	diagnoses	diagnosis	NNS
cord-346853-0c1qdjb5	109	49	makes	make	VBZ
cord-346853-0c1qdjb5	109	50	it	-PRON-	PRP
cord-346853-0c1qdjb5	109	51	difficult	difficult	JJ
cord-346853-0c1qdjb5	109	52	to	to	TO
cord-346853-0c1qdjb5	109	53	determine	determine	VB
cord-346853-0c1qdjb5	109	54	whether	whether	IN
cord-346853-0c1qdjb5	109	55	emerging	emerge	VBG
cord-346853-0c1qdjb5	109	56	viruses	virus	NNS
cord-346853-0c1qdjb5	109	57	are	be	VBP
cord-346853-0c1qdjb5	109	58	more	more	RBR
cord-346853-0c1qdjb5	109	59	common	common	JJ
cord-346853-0c1qdjb5	109	60	now	now	RB
cord-346853-0c1qdjb5	109	61	than	than	IN
cord-346853-0c1qdjb5	109	62	at	at	IN
cord-346853-0c1qdjb5	109	63	previous	previous	JJ
cord-346853-0c1qdjb5	109	64	times	time	NNS
cord-346853-0c1qdjb5	109	65	in	in	IN
cord-346853-0c1qdjb5	109	66	our	-PRON-	PRP$
cord-346853-0c1qdjb5	109	67	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	109	68	history	history	NN
cord-346853-0c1qdjb5	109	69	)	)	-RRB-
cord-346853-0c1qdjb5	109	70	.	.	.
cord-346853-0c1qdjb5	110	1	Turning	turn	VBG
cord-346853-0c1qdjb5	110	2	the	the	DT
cord-346853-0c1qdjb5	110	3	tables	table	NNS
cord-346853-0c1qdjb5	110	4	,	,	,
cord-346853-0c1qdjb5	110	5	there	there	EX
cord-346853-0c1qdjb5	110	6	are	be	VBP
cord-346853-0c1qdjb5	110	7	also	also	RB
cord-346853-0c1qdjb5	110	8	examples	example	NNS
cord-346853-0c1qdjb5	110	9	of	of	IN
cord-346853-0c1qdjb5	110	10	humans	human	NNS
cord-346853-0c1qdjb5	110	11	transmitting	transmit	VBG
cord-346853-0c1qdjb5	110	12	their	-PRON-	PRP$
cord-346853-0c1qdjb5	110	13	viruses	virus	NNS
cord-346853-0c1qdjb5	110	14	to	to	IN
cord-346853-0c1qdjb5	110	15	other	other	JJ
cord-346853-0c1qdjb5	110	16	primates	primate	NNS
cord-346853-0c1qdjb5	110	17	(	(	-LRB-
cord-346853-0c1qdjb5	110	18	often	often	RB
cord-346853-0c1qdjb5	110	19	with	with	IN
cord-346853-0c1qdjb5	110	20	serious	serious	JJ
cord-346853-0c1qdjb5	110	21	consequences	consequence	NNS
cord-346853-0c1qdjb5	110	22	)	)	-RRB-
cord-346853-0c1qdjb5	110	23	,	,	,
cord-346853-0c1qdjb5	110	24	as	as	IN
cord-346853-0c1qdjb5	110	25	appears	appear	VBZ
cord-346853-0c1qdjb5	110	26	to	to	TO
cord-346853-0c1qdjb5	110	27	be	be	VB
cord-346853-0c1qdjb5	110	28	the	the	DT
cord-346853-0c1qdjb5	110	29	case	case	NN
cord-346853-0c1qdjb5	110	30	for	for	IN
cord-346853-0c1qdjb5	110	31	measles	measle	NNS
cord-346853-0c1qdjb5	110	32	(	(	-LRB-
cord-346853-0c1qdjb5	110	33	Ferber	Ferber	NNP
cord-346853-0c1qdjb5	110	34	2000	2000	CD
cord-346853-0c1qdjb5	110	35	)	)	-RRB-
cord-346853-0c1qdjb5	110	36	and	and	CC
cord-346853-0c1qdjb5	110	37	TTV	TTV	NNP
cord-346853-0c1qdjb5	110	38	(	(	-LRB-
cord-346853-0c1qdjb5	110	39	Okamoto	Okamoto	NNP
cord-346853-0c1qdjb5	110	40	et	et	NNP
cord-346853-0c1qdjb5	110	41	al	al	NNP
cord-346853-0c1qdjb5	110	42	.	.	.
cord-346853-0c1qdjb5	110	43	2000	2000	CD
cord-346853-0c1qdjb5	110	44	)	)	-RRB-
cord-346853-0c1qdjb5	110	45	.	.	.
cord-346853-0c1qdjb5	111	1	This	this	DT
cord-346853-0c1qdjb5	111	2	will	will	MD
cord-346853-0c1qdjb5	111	3	doubtless	doubtless	RB
cord-346853-0c1qdjb5	111	4	be	be	VB
cord-346853-0c1qdjb5	111	5	a	a	DT
cord-346853-0c1qdjb5	111	6	continuing	continue	VBG
cord-346853-0c1qdjb5	111	7	problem	problem	NN
cord-346853-0c1qdjb5	111	8	,	,	,
cord-346853-0c1qdjb5	111	9	as	as	IN
cord-346853-0c1qdjb5	111	10	perhaps	perhaps	RB
cord-346853-0c1qdjb5	111	11	will	will	MD
cord-346853-0c1qdjb5	111	12	be	be	VB
cord-346853-0c1qdjb5	111	13	the	the	DT
cord-346853-0c1qdjb5	111	14	movement	movement	NN
cord-346853-0c1qdjb5	111	15	of	of	IN
cord-346853-0c1qdjb5	111	16	viruses	virus	NNS
cord-346853-0c1qdjb5	111	17	from	from	IN
cord-346853-0c1qdjb5	111	18	the	the	DT
cord-346853-0c1qdjb5	111	19	populations	population	NNS
cord-346853-0c1qdjb5	111	20	of	of	IN
cord-346853-0c1qdjb5	111	21	industrialized	industrialize	VBN
cord-346853-0c1qdjb5	111	22	nations	nation	NNS
cord-346853-0c1qdjb5	111	23	to	to	IN
cord-346853-0c1qdjb5	111	24	indigenous	indigenous	JJ
cord-346853-0c1qdjb5	111	25	peoples	people	NNS
cord-346853-0c1qdjb5	111	26	with	with	IN
cord-346853-0c1qdjb5	111	27	naïve	naïve	JJ
cord-346853-0c1qdjb5	111	28	genetic	genetic	JJ
cord-346853-0c1qdjb5	111	29	backgrounds	background	NNS
cord-346853-0c1qdjb5	111	30	.	.	.
cord-346853-0c1qdjb5	112	1	There	there	EX
cord-346853-0c1qdjb5	112	2	are	be	VBP
cord-346853-0c1qdjb5	112	3	also	also	RB
cord-346853-0c1qdjb5	112	4	good	good	JJ
cord-346853-0c1qdjb5	112	5	mechanistic	mechanistic	JJ
cord-346853-0c1qdjb5	112	6	reasons	reason	NNS
cord-346853-0c1qdjb5	112	7	for	for	IN
cord-346853-0c1qdjb5	112	8	believing	believe	VBG
cord-346853-0c1qdjb5	112	9	that	that	IN
cord-346853-0c1qdjb5	112	10	there	there	EX
cord-346853-0c1qdjb5	112	11	is	be	VBZ
cord-346853-0c1qdjb5	112	12	a	a	DT
cord-346853-0c1qdjb5	112	13	relationship	relationship	NN
cord-346853-0c1qdjb5	112	14	between	between	IN
cord-346853-0c1qdjb5	112	15	phylogenetic	phylogenetic	JJ
cord-346853-0c1qdjb5	112	16	distance	distance	NN
cord-346853-0c1qdjb5	112	17	and	and	CC
cord-346853-0c1qdjb5	112	18	the	the	DT
cord-346853-0c1qdjb5	112	19	likelihood	likelihood	NN
cord-346853-0c1qdjb5	112	20	of	of	IN
cord-346853-0c1qdjb5	112	21	viral	viral	JJ
cord-346853-0c1qdjb5	112	22	emergence	emergence	NN
cord-346853-0c1qdjb5	112	23	.	.	.
cord-346853-0c1qdjb5	113	1	In	in	IN
cord-346853-0c1qdjb5	113	2	particular	particular	JJ
cord-346853-0c1qdjb5	113	3	,	,	,
cord-346853-0c1qdjb5	113	4	if	if	IN
cord-346853-0c1qdjb5	113	5	,	,	,
cord-346853-0c1qdjb5	113	6	as	as	IN
cord-346853-0c1qdjb5	113	7	argued	argue	VBN
cord-346853-0c1qdjb5	113	8	above	above	RB
cord-346853-0c1qdjb5	113	9	,	,	,
cord-346853-0c1qdjb5	113	10	the	the	DT
cord-346853-0c1qdjb5	113	11	ability	ability	NN
cord-346853-0c1qdjb5	113	12	to	to	TO
cord-346853-0c1qdjb5	113	13	recognize	recognize	VB
cord-346853-0c1qdjb5	113	14	and	and	CC
cord-346853-0c1qdjb5	113	15	infect	infect	VB
cord-346853-0c1qdjb5	113	16	host	host	NN
cord-346853-0c1qdjb5	113	17	cells	cell	NNS
cord-346853-0c1qdjb5	113	18	is	be	VBZ
cord-346853-0c1qdjb5	113	19	a	a	DT
cord-346853-0c1qdjb5	113	20	key	key	JJ
cord-346853-0c1qdjb5	113	21	component	component	NN
cord-346853-0c1qdjb5	113	22	of	of	IN
cord-346853-0c1qdjb5	113	23	cross	cross	JJ
cord-346853-0c1qdjb5	113	24	-	-	JJ
cord-346853-0c1qdjb5	113	25	species	species	JJ
cord-346853-0c1qdjb5	113	26	transmission	transmission	NN
cord-346853-0c1qdjb5	113	27	,	,	,
cord-346853-0c1qdjb5	113	28	then	then	RB
cord-346853-0c1qdjb5	113	29	phylogenetically	phylogenetically	RB
cord-346853-0c1qdjb5	113	30	related	relate	VBN
cord-346853-0c1qdjb5	113	31	host	host	NN
cord-346853-0c1qdjb5	113	32	species	specie	NNS
cord-346853-0c1qdjb5	113	33	are	be	VBP
cord-346853-0c1qdjb5	113	34	more	more	RBR
cord-346853-0c1qdjb5	113	35	likely	likely	JJ
cord-346853-0c1qdjb5	113	36	to	to	TO
cord-346853-0c1qdjb5	113	37	share	share	VB
cord-346853-0c1qdjb5	113	38	related	related	JJ
cord-346853-0c1qdjb5	113	39	cell	cell	NN
cord-346853-0c1qdjb5	113	40	receptors	receptor	NNS
cord-346853-0c1qdjb5	113	41	.	.	.
cord-346853-0c1qdjb5	114	1	Given	give	VBN
cord-346853-0c1qdjb5	114	2	the	the	DT
cord-346853-0c1qdjb5	114	3	pace	pace	NN
cord-346853-0c1qdjb5	114	4	at	at	IN
cord-346853-0c1qdjb5	114	5	which	which	WDT
cord-346853-0c1qdjb5	114	6	RNA	RNA	NNP
cord-346853-0c1qdjb5	114	7	viruses	virus	NNS
cord-346853-0c1qdjb5	114	8	evolve	evolve	VBP
cord-346853-0c1qdjb5	114	9	,	,	,
cord-346853-0c1qdjb5	114	10	it	-PRON-	PRP
cord-346853-0c1qdjb5	114	11	is	be	VBZ
cord-346853-0c1qdjb5	114	12	easy	easy	JJ
cord-346853-0c1qdjb5	114	13	to	to	TO
cord-346853-0c1qdjb5	114	14	see	see	VB
cord-346853-0c1qdjb5	114	15	that	that	DT
cord-346853-0c1qdjb5	114	16	highly	highly	RB
cord-346853-0c1qdjb5	114	17	dependent	dependent	JJ
cord-346853-0c1qdjb5	114	18	relationships	relationship	NNS
cord-346853-0c1qdjb5	114	19	between	between	IN
cord-346853-0c1qdjb5	114	20	viruses	virus	NNS
cord-346853-0c1qdjb5	114	21	and	and	CC
cord-346853-0c1qdjb5	114	22	cell	cell	NN
cord-346853-0c1qdjb5	114	23	receptors	receptor	NNS
cord-346853-0c1qdjb5	114	24	will	will	MD
cord-346853-0c1qdjb5	114	25	be	be	VB
cord-346853-0c1qdjb5	114	26	quickly	quickly	RB
cord-346853-0c1qdjb5	114	27	established	establish	VBN
cord-346853-0c1qdjb5	114	28	,	,	,
cord-346853-0c1qdjb5	114	29	so	so	IN
cord-346853-0c1qdjb5	114	30	that	that	IN
cord-346853-0c1qdjb5	114	31	the	the	DT
cord-346853-0c1qdjb5	114	32	probability	probability	NN
cord-346853-0c1qdjb5	114	33	of	of	IN
cord-346853-0c1qdjb5	114	34	successful	successful	JJ
cord-346853-0c1qdjb5	114	35	cross	cross	JJ
cord-346853-0c1qdjb5	114	36	-	-	JJ
cord-346853-0c1qdjb5	114	37	species	species	JJ
cord-346853-0c1qdjb5	114	38	transmission	transmission	NN
cord-346853-0c1qdjb5	114	39	will	will	MD
cord-346853-0c1qdjb5	114	40	decrease	decrease	VB
cord-346853-0c1qdjb5	114	41	with	with	IN
cord-346853-0c1qdjb5	114	42	increasing	increase	VBG
cord-346853-0c1qdjb5	114	43	phylogenetic	phylogenetic	JJ
cord-346853-0c1qdjb5	114	44	distance	distance	NN
cord-346853-0c1qdjb5	114	45	.	.	.
cord-346853-0c1qdjb5	115	1	If	if	IN
cord-346853-0c1qdjb5	115	2	true	true	JJ
cord-346853-0c1qdjb5	115	3	,	,	,
cord-346853-0c1qdjb5	115	4	this	this	DT
cord-346853-0c1qdjb5	115	5	theory	theory	NN
cord-346853-0c1qdjb5	115	6	further	further	RB
cord-346853-0c1qdjb5	115	7	predicts	predict	VBZ
cord-346853-0c1qdjb5	115	8	that	that	IN
cord-346853-0c1qdjb5	115	9	the	the	DT
cord-346853-0c1qdjb5	115	10	more	more	RBR
cord-346853-0c1qdjb5	115	11	slowly	slowly	RB
cord-346853-0c1qdjb5	115	12	evolving	evolve	VBG
cord-346853-0c1qdjb5	115	13	DNA	dna	NN
cord-346853-0c1qdjb5	115	14	viruses	virus	NNS
cord-346853-0c1qdjb5	115	15	should	should	MD
cord-346853-0c1qdjb5	115	16	initially	initially	RB
cord-346853-0c1qdjb5	115	17	be	be	VB
cord-346853-0c1qdjb5	115	18	able	able	JJ
cord-346853-0c1qdjb5	115	19	to	to	TO
cord-346853-0c1qdjb5	115	20	jump	jump	VB
cord-346853-0c1qdjb5	115	21	wider	wide	JJR
cord-346853-0c1qdjb5	115	22	phylogenetic	phylogenetic	JJ
cord-346853-0c1qdjb5	115	23	boundaries	boundary	NNS
cord-346853-0c1qdjb5	116	1	but	but	CC
cord-346853-0c1qdjb5	116	2	,	,	,
cord-346853-0c1qdjb5	116	3	when	when	WRB
cord-346853-0c1qdjb5	116	4	they	-PRON-	PRP
cord-346853-0c1qdjb5	116	5	do	do	VBP
cord-346853-0c1qdjb5	116	6	adapt	adapt	VB
cord-346853-0c1qdjb5	116	7	to	to	IN
cord-346853-0c1qdjb5	116	8	their	-PRON-	PRP$
cord-346853-0c1qdjb5	116	9	host	host	NN
cord-346853-0c1qdjb5	116	10	,	,	,
cord-346853-0c1qdjb5	116	11	will	will	MD
cord-346853-0c1qdjb5	116	12	eventually	eventually	RB
cord-346853-0c1qdjb5	116	13	find	find	VB
cord-346853-0c1qdjb5	116	14	it	-PRON-	PRP
cord-346853-0c1qdjb5	116	15	much	much	RB
cord-346853-0c1qdjb5	116	16	more	more	RBR
cord-346853-0c1qdjb5	116	17	difficult	difficult	JJ
cord-346853-0c1qdjb5	116	18	to	to	TO
cord-346853-0c1qdjb5	116	19	make	make	VB
cord-346853-0c1qdjb5	116	20	subsequent	subsequent	JJ
cord-346853-0c1qdjb5	116	21	species	specie	NNS
cord-346853-0c1qdjb5	116	22	jumps	jump	VBZ
cord-346853-0c1qdjb5	116	23	.	.	.
cord-346853-0c1qdjb5	117	1	This	this	DT
cord-346853-0c1qdjb5	117	2	pattern	pattern	NN
cord-346853-0c1qdjb5	117	3	may	may	MD
cord-346853-0c1qdjb5	117	4	partly	partly	RB
cord-346853-0c1qdjb5	117	5	explain	explain	VB
cord-346853-0c1qdjb5	117	6	the	the	DT
cord-346853-0c1qdjb5	117	7	tendency	tendency	NN
cord-346853-0c1qdjb5	117	8	for	for	IN
cord-346853-0c1qdjb5	117	9	slower	slow	RBR
cord-346853-0c1qdjb5	117	10	-	-	HYPH
cord-346853-0c1qdjb5	117	11	evolving	evolve	VBG
cord-346853-0c1qdjb5	117	12	DNA	dna	NN
cord-346853-0c1qdjb5	117	13	viruses	virus	NNS
cord-346853-0c1qdjb5	117	14	to	to	TO
cord-346853-0c1qdjb5	117	15	co	co	VB
cord-346853-0c1qdjb5	117	16	-	-	VB
cord-346853-0c1qdjb5	117	17	diverge	diverge	VB
cord-346853-0c1qdjb5	117	18	rather	rather	RB
cord-346853-0c1qdjb5	117	19	than	than	IN
cord-346853-0c1qdjb5	117	20	move	move	VB
cord-346853-0c1qdjb5	117	21	horizontally	horizontally	RB
cord-346853-0c1qdjb5	117	22	among	among	IN
cord-346853-0c1qdjb5	117	23	species	specie	NNS
cord-346853-0c1qdjb5	117	24	(	(	-LRB-
cord-346853-0c1qdjb5	117	25	Holmes	Holmes	NNP
cord-346853-0c1qdjb5	117	26	2004	2004	CD
cord-346853-0c1qdjb5	117	27	)	)	-RRB-
cord-346853-0c1qdjb5	117	28	.	.	.
cord-346853-0c1qdjb5	118	1	There	there	EX
cord-346853-0c1qdjb5	118	2	are	be	VBP
cord-346853-0c1qdjb5	118	3	,	,	,
cord-346853-0c1qdjb5	118	4	however	however	RB
cord-346853-0c1qdjb5	118	5	,	,	,
cord-346853-0c1qdjb5	118	6	some	some	DT
cord-346853-0c1qdjb5	118	7	complicating	complicate	VBG
cord-346853-0c1qdjb5	118	8	factors	factor	NNS
cord-346853-0c1qdjb5	118	9	to	to	IN
cord-346853-0c1qdjb5	118	10	this	this	DT
cord-346853-0c1qdjb5	118	11	simple	simple	JJ
cord-346853-0c1qdjb5	118	12	phylogenetic	phylogenetic	JJ
cord-346853-0c1qdjb5	118	13	rule	rule	NN
cord-346853-0c1qdjb5	118	14	.	.	.
cord-346853-0c1qdjb5	119	1	The	the	DT
cord-346853-0c1qdjb5	119	2	issue	issue	NN
cord-346853-0c1qdjb5	119	3	of	of	IN
cord-346853-0c1qdjb5	119	4	exposure	exposure	NN
cord-346853-0c1qdjb5	119	5	vs	vs	IN
cord-346853-0c1qdjb5	119	6	transmissibility	transmissibility	NN
cord-346853-0c1qdjb5	119	7	has	have	VBZ
cord-346853-0c1qdjb5	119	8	been	be	VBN
cord-346853-0c1qdjb5	119	9	discussed	discuss	VBN
cord-346853-0c1qdjb5	119	10	above	above	RB
cord-346853-0c1qdjb5	119	11	.	.	.
cord-346853-0c1qdjb5	120	1	There	there	EX
cord-346853-0c1qdjb5	120	2	are	be	VBP
cord-346853-0c1qdjb5	120	3	also	also	RB
cord-346853-0c1qdjb5	120	4	numerous	numerous	JJ
cord-346853-0c1qdjb5	120	5	exceptions	exception	NNS
cord-346853-0c1qdjb5	120	6	to	to	IN
cord-346853-0c1qdjb5	120	7	the	the	DT
cord-346853-0c1qdjb5	120	8	phylogenetic	phylogenetic	JJ
cord-346853-0c1qdjb5	120	9	trend	trend	NN
cord-346853-0c1qdjb5	120	10	.	.	.
cord-346853-0c1qdjb5	121	1	In	in	IN
cord-346853-0c1qdjb5	121	2	particular	particular	JJ
cord-346853-0c1qdjb5	121	3	,	,	,
cord-346853-0c1qdjb5	121	4	a	a	DT
cord-346853-0c1qdjb5	121	5	large	large	JJ
cord-346853-0c1qdjb5	121	6	number	number	NN
cord-346853-0c1qdjb5	121	7	of	of	IN
cord-346853-0c1qdjb5	121	8	the	the	DT
cord-346853-0c1qdjb5	121	9	emerging	emerge	VBG
cord-346853-0c1qdjb5	121	10	viruses	virus	NNS
cord-346853-0c1qdjb5	121	11	of	of	IN
cord-346853-0c1qdjb5	121	12	humans	human	NNS
cord-346853-0c1qdjb5	121	13	appear	appear	VBP
cord-346853-0c1qdjb5	121	14	to	to	TO
cord-346853-0c1qdjb5	121	15	have	have	VB
cord-346853-0c1qdjb5	121	16	arisen	arise	VBN
cord-346853-0c1qdjb5	121	17	from	from	IN
cord-346853-0c1qdjb5	121	18	rodents	rodent	NNS
cord-346853-0c1qdjb5	121	19	rather	rather	RB
cord-346853-0c1qdjb5	121	20	than	than	IN
cord-346853-0c1qdjb5	121	21	primates	primate	NNS
cord-346853-0c1qdjb5	121	22	(	(	-LRB-
cord-346853-0c1qdjb5	121	23	M.E.J.	M.E.J.	NNP
cord-346853-0c1qdjb5	121	24	Woolhouse	Woolhouse	NNP
cord-346853-0c1qdjb5	121	25	,	,	,
cord-346853-0c1qdjb5	121	26	personal	personal	JJ
cord-346853-0c1qdjb5	121	27	communication	communication	NN
cord-346853-0c1qdjb5	121	28	)	)	-RRB-
cord-346853-0c1qdjb5	121	29	.	.	.
cord-346853-0c1qdjb5	122	1	This	this	DT
cord-346853-0c1qdjb5	122	2	implies	imply	VBZ
cord-346853-0c1qdjb5	122	3	that	that	IN
cord-346853-0c1qdjb5	122	4	the	the	DT
cord-346853-0c1qdjb5	122	5	high	high	JJ
cord-346853-0c1qdjb5	122	6	density	density	NN
cord-346853-0c1qdjb5	122	7	of	of	IN
cord-346853-0c1qdjb5	122	8	many	many	JJ
cord-346853-0c1qdjb5	122	9	rodent	rodent	NN
cord-346853-0c1qdjb5	122	10	populations	population	NNS
cord-346853-0c1qdjb5	122	11	allows	allow	VBZ
cord-346853-0c1qdjb5	122	12	them	-PRON-	PRP
cord-346853-0c1qdjb5	122	13	to	to	TO
cord-346853-0c1qdjb5	122	14	carry	carry	VB
cord-346853-0c1qdjb5	122	15	a	a	DT
cord-346853-0c1qdjb5	122	16	greater	great	JJR
cord-346853-0c1qdjb5	122	17	diversity	diversity	NN
cord-346853-0c1qdjb5	122	18	of	of	IN
cord-346853-0c1qdjb5	122	19	pathogens	pathogen	NNS
cord-346853-0c1qdjb5	122	20	and/or	and/or	CC
cord-346853-0c1qdjb5	122	21	that	that	IN
cord-346853-0c1qdjb5	122	22	rodents	rodent	NNS
cord-346853-0c1qdjb5	122	23	often	often	RB
cord-346853-0c1qdjb5	122	24	live	live	VBP
cord-346853-0c1qdjb5	122	25	in	in	IN
cord-346853-0c1qdjb5	122	26	close	close	JJ
cord-346853-0c1qdjb5	122	27	proximity	proximity	NN
cord-346853-0c1qdjb5	122	28	to	to	IN
cord-346853-0c1qdjb5	122	29	humans	human	NNS
cord-346853-0c1qdjb5	122	30	which	which	WDT
cord-346853-0c1qdjb5	122	31	increases	increase	VBZ
cord-346853-0c1qdjb5	122	32	the	the	DT
cord-346853-0c1qdjb5	122	33	probability	probability	NN
cord-346853-0c1qdjb5	122	34	of	of	IN
cord-346853-0c1qdjb5	122	35	exposure	exposure	NN
cord-346853-0c1qdjb5	122	36	(	(	-LRB-
cord-346853-0c1qdjb5	122	37	see	see	VB
cord-346853-0c1qdjb5	122	38	the	the	DT
cord-346853-0c1qdjb5	122	39	chapters	chapter	NNS
cord-346853-0c1qdjb5	122	40	by	by	IN
cord-346853-0c1qdjb5	122	41	Gonzalez	Gonzalez	NNP
cord-346853-0c1qdjb5	122	42	et	et	NNP
cord-346853-0c1qdjb5	122	43	al	al	NNP
cord-346853-0c1qdjb5	122	44	.	.	.
cord-346853-0c1qdjb5	123	1	and	and	CC
cord-346853-0c1qdjb5	123	2	Klein	Klein	NNP
cord-346853-0c1qdjb5	123	3	and	and	CC
cord-346853-0c1qdjb5	123	4	Calisher	Calisher	NNP
cord-346853-0c1qdjb5	123	5	,	,	,
cord-346853-0c1qdjb5	123	6	this	this	DT
cord-346853-0c1qdjb5	123	7	volume	volume	NN
cord-346853-0c1qdjb5	123	8	)	)	-RRB-
cord-346853-0c1qdjb5	123	9	.	.	.
cord-346853-0c1qdjb5	124	1	Another	another	DT
cord-346853-0c1qdjb5	124	2	factor	factor	NN
cord-346853-0c1qdjb5	124	3	of	of	IN
cord-346853-0c1qdjb5	124	4	potential	potential	JJ
cord-346853-0c1qdjb5	124	5	importance	importance	NN
cord-346853-0c1qdjb5	124	6	is	be	VBZ
cord-346853-0c1qdjb5	124	7	phylogenetically	phylogenetically	RB
cord-346853-0c1qdjb5	124	8	related	relate	VBN
cord-346853-0c1qdjb5	124	9	immune	immune	JJ
cord-346853-0c1qdjb5	124	10	responses	response	NNS
cord-346853-0c1qdjb5	124	11	.	.	.
cord-346853-0c1qdjb5	125	1	Specifically	specifically	RB
cord-346853-0c1qdjb5	125	2	,	,	,
cord-346853-0c1qdjb5	125	3	closely	closely	RB
cord-346853-0c1qdjb5	125	4	related	related	JJ
cord-346853-0c1qdjb5	125	5	host	host	NN
cord-346853-0c1qdjb5	125	6	species	specie	NNS
cord-346853-0c1qdjb5	125	7	,	,	,
cord-346853-0c1qdjb5	125	8	such	such	JJ
cord-346853-0c1qdjb5	125	9	as	as	IN
cord-346853-0c1qdjb5	125	10	humans	human	NNS
cord-346853-0c1qdjb5	125	11	and	and	CC
cord-346853-0c1qdjb5	125	12	other	other	JJ
cord-346853-0c1qdjb5	125	13	primates	primate	NNS
cord-346853-0c1qdjb5	125	14	,	,	,
cord-346853-0c1qdjb5	125	15	are	be	VBP
cord-346853-0c1qdjb5	125	16	also	also	RB
cord-346853-0c1qdjb5	125	17	likely	likely	JJ
cord-346853-0c1qdjb5	125	18	to	to	TO
cord-346853-0c1qdjb5	125	19	share	share	VB
cord-346853-0c1qdjb5	125	20	the	the	DT
cord-346853-0c1qdjb5	125	21	alleles	allele	NNS
cord-346853-0c1qdjb5	125	22	that	that	WDT
cord-346853-0c1qdjb5	125	23	determine	determine	VBP
cord-346853-0c1qdjb5	125	24	immune	immune	JJ
cord-346853-0c1qdjb5	125	25	responses	response	NNS
cord-346853-0c1qdjb5	125	26	to	to	IN
cord-346853-0c1qdjb5	125	27	specific	specific	JJ
cord-346853-0c1qdjb5	125	28	pathogens	pathogen	NNS
cord-346853-0c1qdjb5	125	29	.	.	.
cord-346853-0c1qdjb5	126	1	This	this	DT
cord-346853-0c1qdjb5	126	2	has	have	VBZ
cord-346853-0c1qdjb5	126	3	been	be	VBN
cord-346853-0c1qdjb5	126	4	particularly	particularly	RB
cord-346853-0c1qdjb5	126	5	well	well	RB
cord-346853-0c1qdjb5	126	6	documented	document	VBN
cord-346853-0c1qdjb5	126	7	for	for	IN
cord-346853-0c1qdjb5	126	8	the	the	DT
cord-346853-0c1qdjb5	126	9	major	major	JJ
cord-346853-0c1qdjb5	126	10	histocompatibility	histocompatibility	NN
cord-346853-0c1qdjb5	126	11	complex	complex	NN
cord-346853-0c1qdjb5	126	12	(	(	-LRB-
cord-346853-0c1qdjb5	126	13	MHC	MHC	NNP
cord-346853-0c1qdjb5	126	14	)	)	-RRB-
cord-346853-0c1qdjb5	126	15	group	group	NN
cord-346853-0c1qdjb5	126	16	of	of	IN
cord-346853-0c1qdjb5	126	17	loci	locus	NNS
cord-346853-0c1qdjb5	126	18	,	,	,
cord-346853-0c1qdjb5	126	19	in	in	IN
cord-346853-0c1qdjb5	126	20	which	which	WDT
cord-346853-0c1qdjb5	126	21	certain	certain	JJ
cord-346853-0c1qdjb5	126	22	allelic	allelic	JJ
cord-346853-0c1qdjb5	126	23	lineages	lineage	NNS
cord-346853-0c1qdjb5	126	24	have	have	VBP
cord-346853-0c1qdjb5	126	25	persisted	persist	VBN
cord-346853-0c1qdjb5	126	26	for	for	IN
cord-346853-0c1qdjb5	126	27	millions	million	NNS
cord-346853-0c1qdjb5	126	28	of	of	IN
cord-346853-0c1qdjb5	126	29	years	year	NNS
cord-346853-0c1qdjb5	126	30	of	of	IN
cord-346853-0c1qdjb5	126	31	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	126	32	history	history	NN
cord-346853-0c1qdjb5	126	33	(	(	-LRB-
cord-346853-0c1qdjb5	126	34	Figueroa	Figueroa	NNP
cord-346853-0c1qdjb5	126	35	et	et	NNP
cord-346853-0c1qdjb5	126	36	al	al	NNP
cord-346853-0c1qdjb5	126	37	.	.	.
cord-346853-0c1qdjb5	126	38	1988	1988	CD
cord-346853-0c1qdjb5	126	39	)	)	-RRB-
cord-346853-0c1qdjb5	126	40	.	.	.
cord-346853-0c1qdjb5	127	1	Consequently	consequently	RB
cord-346853-0c1qdjb5	127	2	,	,	,
cord-346853-0c1qdjb5	127	3	although	although	IN
cord-346853-0c1qdjb5	127	4	a	a	DT
cord-346853-0c1qdjb5	127	5	species	species	NN
cord-346853-0c1qdjb5	127	6	might	may	MD
cord-346853-0c1qdjb5	127	7	be	be	VB
cord-346853-0c1qdjb5	127	8	exposed	expose	VBN
cord-346853-0c1qdjb5	127	9	to	to	IN
cord-346853-0c1qdjb5	127	10	a	a	DT
cord-346853-0c1qdjb5	127	11	novel	novel	JJ
cord-346853-0c1qdjb5	127	12	pathogen	pathogen	NN
cord-346853-0c1qdjb5	127	13	,	,	,
cord-346853-0c1qdjb5	127	14	they	-PRON-	PRP
cord-346853-0c1qdjb5	127	15	might	may	MD
cord-346853-0c1qdjb5	127	16	,	,	,
cord-346853-0c1qdjb5	127	17	through	through	IN
cord-346853-0c1qdjb5	127	18	a	a	DT
cord-346853-0c1qdjb5	127	19	combination	combination	NN
cord-346853-0c1qdjb5	127	20	of	of	IN
cord-346853-0c1qdjb5	127	21	shared	share	VBN
cord-346853-0c1qdjb5	127	22	common	common	JJ
cord-346853-0c1qdjb5	127	23	ancestry	ancestry	NN
cord-346853-0c1qdjb5	127	24	and	and	CC
cord-346853-0c1qdjb5	127	25	good	good	JJ
cord-346853-0c1qdjb5	127	26	fortune	fortune	NN
cord-346853-0c1qdjb5	127	27	,	,	,
cord-346853-0c1qdjb5	127	28	already	already	RB
cord-346853-0c1qdjb5	127	29	possess	possess	VBP
cord-346853-0c1qdjb5	127	30	a	a	DT
cord-346853-0c1qdjb5	127	31	sufficient	sufficient	JJ
cord-346853-0c1qdjb5	127	32	immune	immune	JJ
cord-346853-0c1qdjb5	127	33	response	response	NN
cord-346853-0c1qdjb5	127	34	to	to	TO
cord-346853-0c1qdjb5	127	35	prevent	prevent	VB
cord-346853-0c1qdjb5	127	36	the	the	DT
cord-346853-0c1qdjb5	127	37	infection	infection	NN
cord-346853-0c1qdjb5	127	38	from	from	IN
cord-346853-0c1qdjb5	127	39	being	be	VBG
cord-346853-0c1qdjb5	127	40	established	establish	VBN
cord-346853-0c1qdjb5	127	41	.	.	.
cord-346853-0c1qdjb5	128	1	Understandably	understandably	RB
cord-346853-0c1qdjb5	128	2	,	,	,
cord-346853-0c1qdjb5	128	3	most	most	JJS
cord-346853-0c1qdjb5	128	4	definitions	definition	NNS
cord-346853-0c1qdjb5	128	5	of	of	IN
cord-346853-0c1qdjb5	128	6	emerging	emerge	VBG
cord-346853-0c1qdjb5	128	7	viruses	virus	NNS
cord-346853-0c1qdjb5	128	8	focus	focus	VBP
cord-346853-0c1qdjb5	128	9	on	on	IN
cord-346853-0c1qdjb5	128	10	the	the	DT
cord-346853-0c1qdjb5	128	11	issue	issue	NN
cord-346853-0c1qdjb5	128	12	of	of	IN
cord-346853-0c1qdjb5	128	13	disease	disease	NN
cord-346853-0c1qdjb5	128	14	.	.	.
cord-346853-0c1qdjb5	129	1	This	this	DT
cord-346853-0c1qdjb5	129	2	means	mean	VBZ
cord-346853-0c1qdjb5	129	3	that	that	IN
cord-346853-0c1qdjb5	129	4	no	no	DT
cord-346853-0c1qdjb5	129	5	distinction	distinction	NN
cord-346853-0c1qdjb5	129	6	is	be	VBZ
cord-346853-0c1qdjb5	129	7	drawn	draw	VBN
cord-346853-0c1qdjb5	129	8	between	between	IN
cord-346853-0c1qdjb5	129	9	those	those	DT
cord-346853-0c1qdjb5	129	10	viruses	virus	NNS
cord-346853-0c1qdjb5	129	11	that	that	WDT
cord-346853-0c1qdjb5	129	12	spread	spread	VBD
cord-346853-0c1qdjb5	129	13	efficiently	efficiently	RB
cord-346853-0c1qdjb5	129	14	among	among	IN
cord-346853-0c1qdjb5	129	15	us	-PRON-	PRP
cord-346853-0c1qdjb5	129	16	,	,	,
cord-346853-0c1qdjb5	129	17	and	and	CC
cord-346853-0c1qdjb5	129	18	those	those	DT
cord-346853-0c1qdjb5	129	19	that	that	WDT
cord-346853-0c1qdjb5	129	20	only	only	RB
cord-346853-0c1qdjb5	129	21	cause	cause	VBP
cord-346853-0c1qdjb5	129	22	sporadic	sporadic	JJ
cord-346853-0c1qdjb5	129	23	disease	disease	NN
cord-346853-0c1qdjb5	129	24	,	,	,
cord-346853-0c1qdjb5	129	25	often	often	RB
cord-346853-0c1qdjb5	129	26	with	with	IN
cord-346853-0c1qdjb5	129	27	no	no	DT
cord-346853-0c1qdjb5	129	28	human	human	NN
cord-346853-0c1qdjb5	129	29	-	-	HYPH
cord-346853-0c1qdjb5	129	30	to	to	IN
cord-346853-0c1qdjb5	129	31	-	-	HYPH
cord-346853-0c1qdjb5	129	32	human	human	JJ
cord-346853-0c1qdjb5	129	33	transmission	transmission	NN
cord-346853-0c1qdjb5	129	34	.	.	.
cord-346853-0c1qdjb5	130	1	Indeed	indeed	RB
cord-346853-0c1qdjb5	130	2	,	,	,
cord-346853-0c1qdjb5	130	3	it	-PRON-	PRP
cord-346853-0c1qdjb5	130	4	seems	seem	VBZ
cord-346853-0c1qdjb5	130	5	that	that	IN
cord-346853-0c1qdjb5	130	6	many	many	JJ
cord-346853-0c1qdjb5	130	7	,	,	,
cord-346853-0c1qdjb5	130	8	if	if	IN
cord-346853-0c1qdjb5	130	9	not	not	RB
cord-346853-0c1qdjb5	130	10	the	the	DT
cord-346853-0c1qdjb5	130	11	majority	majority	NN
cord-346853-0c1qdjb5	130	12	,	,	,
cord-346853-0c1qdjb5	130	13	of	of	IN
cord-346853-0c1qdjb5	130	14	the	the	DT
cord-346853-0c1qdjb5	130	15	emerging	emerge	VBG
cord-346853-0c1qdjb5	130	16	diseases	disease	NNS
cord-346853-0c1qdjb5	130	17	of	of	IN
cord-346853-0c1qdjb5	130	18	humans	human	NNS
cord-346853-0c1qdjb5	130	19	represent	represent	VBP
cord-346853-0c1qdjb5	130	20	dead	dead	JJ
cord-346853-0c1qdjb5	130	21	-	-	HYPH
cord-346853-0c1qdjb5	130	22	end	end	NN
cord-346853-0c1qdjb5	130	23	infections	infection	NNS
cord-346853-0c1qdjb5	130	24	.	.	.
cord-346853-0c1qdjb5	131	1	This	this	DT
cord-346853-0c1qdjb5	131	2	may	may	MD
cord-346853-0c1qdjb5	131	3	represent	represent	VB
cord-346853-0c1qdjb5	131	4	the	the	DT
cord-346853-0c1qdjb5	131	5	natural	natural	JJ
cord-346853-0c1qdjb5	131	6	background	background	NN
cord-346853-0c1qdjb5	131	7	dynamics	dynamic	NNS
cord-346853-0c1qdjb5	131	8	of	of	IN
cord-346853-0c1qdjb5	131	9	cross	cross	JJ
cord-346853-0c1qdjb5	131	10	-	-	JJ
cord-346853-0c1qdjb5	131	11	species	species	JJ
cord-346853-0c1qdjb5	131	12	transmission	transmission	NN
cord-346853-0c1qdjb5	131	13	.	.	.
cord-346853-0c1qdjb5	132	1	For	for	IN
cord-346853-0c1qdjb5	132	2	example	example	NN
cord-346853-0c1qdjb5	132	3	,	,	,
cord-346853-0c1qdjb5	132	4	almost	almost	RB
cord-346853-0c1qdjb5	132	5	all	all	DT
cord-346853-0c1qdjb5	132	6	avian	avian	JJ
cord-346853-0c1qdjb5	132	7	-	-	HYPH
cord-346853-0c1qdjb5	132	8	to	to	IN
cord-346853-0c1qdjb5	132	9	-	-	HYPH
cord-346853-0c1qdjb5	132	10	human	human	JJ
cord-346853-0c1qdjb5	132	11	transmissions	transmission	NNS
cord-346853-0c1qdjb5	132	12	of	of	IN
cord-346853-0c1qdjb5	132	13	influenza	influenza	NN
cord-346853-0c1qdjb5	132	14	A	a	DT
cord-346853-0c1qdjb5	132	15	virus	virus	NN
cord-346853-0c1qdjb5	132	16	result	result	NN
cord-346853-0c1qdjb5	132	17	in	in	IN
cord-346853-0c1qdjb5	132	18	dead	dead	JJ
cord-346853-0c1qdjb5	132	19	-	-	HYPH
cord-346853-0c1qdjb5	132	20	end	end	NN
cord-346853-0c1qdjb5	132	21	infections	infection	NNS
cord-346853-0c1qdjb5	132	22	,	,	,
cord-346853-0c1qdjb5	132	23	yet	yet	CC
cord-346853-0c1qdjb5	132	24	occasional	occasional	JJ
cord-346853-0c1qdjb5	132	25	avian	avian	JJ
cord-346853-0c1qdjb5	132	26	-	-	HYPH
cord-346853-0c1qdjb5	132	27	to	to	IN
cord-346853-0c1qdjb5	132	28	-	-	HYPH
cord-346853-0c1qdjb5	132	29	human	human	JJ
cord-346853-0c1qdjb5	132	30	transmission	transmission	NN
cord-346853-0c1qdjb5	132	31	can	can	MD
cord-346853-0c1qdjb5	132	32	cause	cause	VB
cord-346853-0c1qdjb5	132	33	pandemics	pandemic	NNS
cord-346853-0c1qdjb5	132	34	.	.	.
cord-346853-0c1qdjb5	133	1	Each	each	DT
cord-346853-0c1qdjb5	133	2	time	time	NN
cord-346853-0c1qdjb5	133	3	a	a	DT
cord-346853-0c1qdjb5	133	4	cross	cross	JJ
cord-346853-0c1qdjb5	133	5	-	-	JJ
cord-346853-0c1qdjb5	133	6	species	species	JJ
cord-346853-0c1qdjb5	133	7	transmission	transmission	NN
cord-346853-0c1qdjb5	133	8	occurs	occur	VBZ
cord-346853-0c1qdjb5	133	9	,	,	,
cord-346853-0c1qdjb5	133	10	there	there	EX
cord-346853-0c1qdjb5	133	11	is	be	VBZ
cord-346853-0c1qdjb5	133	12	a	a	DT
cord-346853-0c1qdjb5	133	13	small	small	JJ
cord-346853-0c1qdjb5	133	14	chance	chance	NN
cord-346853-0c1qdjb5	133	15	that	that	IN
cord-346853-0c1qdjb5	133	16	it	-PRON-	PRP
cord-346853-0c1qdjb5	133	17	will	will	MD
cord-346853-0c1qdjb5	133	18	take	take	VB
cord-346853-0c1qdjb5	133	19	hold	hold	NN
cord-346853-0c1qdjb5	133	20	.	.	.
cord-346853-0c1qdjb5	134	1	The	the	DT
cord-346853-0c1qdjb5	134	2	problem	problem	NN
cord-346853-0c1qdjb5	134	3	is	be	VBZ
cord-346853-0c1qdjb5	134	4	identifying	identify	VBG
cord-346853-0c1qdjb5	134	5	and	and	CC
cord-346853-0c1qdjb5	134	6	quantifying	quantify	VBG
cord-346853-0c1qdjb5	134	7	the	the	DT
cord-346853-0c1qdjb5	134	8	key	key	JJ
cord-346853-0c1qdjb5	134	9	factors	factor	NNS
cord-346853-0c1qdjb5	134	10	that	that	WDT
cord-346853-0c1qdjb5	134	11	determine	determine	VBP
cord-346853-0c1qdjb5	134	12	whether	whether	IN
cord-346853-0c1qdjb5	134	13	a	a	DT
cord-346853-0c1qdjb5	134	14	particular	particular	JJ
cord-346853-0c1qdjb5	134	15	initial	initial	JJ
cord-346853-0c1qdjb5	134	16	infection	infection	NN
cord-346853-0c1qdjb5	134	17	will	will	MD
cord-346853-0c1qdjb5	134	18	survive	survive	VB
cord-346853-0c1qdjb5	134	19	and	and	CC
cord-346853-0c1qdjb5	134	20	grow	grow	VB
cord-346853-0c1qdjb5	134	21	into	into	IN
cord-346853-0c1qdjb5	134	22	a	a	DT
cord-346853-0c1qdjb5	134	23	full	full	RB
cord-346853-0c1qdjb5	134	24	-	-	HYPH
cord-346853-0c1qdjb5	134	25	fledged	fledged	JJ
cord-346853-0c1qdjb5	134	26	epidemic	epidemic	NN
cord-346853-0c1qdjb5	134	27	.	.	.
cord-346853-0c1qdjb5	135	1	To	to	TO
cord-346853-0c1qdjb5	135	2	understand	understand	VB
cord-346853-0c1qdjb5	135	3	emergence	emergence	NN
cord-346853-0c1qdjb5	135	4	,	,	,
cord-346853-0c1qdjb5	135	5	it	-PRON-	PRP
cord-346853-0c1qdjb5	135	6	is	be	VBZ
cord-346853-0c1qdjb5	135	7	therefore	therefore	RB
cord-346853-0c1qdjb5	135	8	crucial	crucial	JJ
cord-346853-0c1qdjb5	135	9	to	to	TO
cord-346853-0c1qdjb5	135	10	understand	understand	VB
cord-346853-0c1qdjb5	135	11	why	why	WRB
cord-346853-0c1qdjb5	135	12	only	only	RB
cord-346853-0c1qdjb5	135	13	some	some	DT
cord-346853-0c1qdjb5	135	14	viruses	virus	NNS
cord-346853-0c1qdjb5	135	15	are	be	VBP
cord-346853-0c1qdjb5	135	16	able	able	JJ
cord-346853-0c1qdjb5	135	17	to	to	TO
cord-346853-0c1qdjb5	135	18	regularly	regularly	RB
cord-346853-0c1qdjb5	135	19	establish	establish	VB
cord-346853-0c1qdjb5	135	20	long	long	JJ
cord-346853-0c1qdjb5	135	21	-	-	HYPH
cord-346853-0c1qdjb5	135	22	term	term	NN
cord-346853-0c1qdjb5	135	23	transmission	transmission	NN
cord-346853-0c1qdjb5	135	24	networks	network	NNS
cord-346853-0c1qdjb5	135	25	(	(	-LRB-
cord-346853-0c1qdjb5	135	26	see	see	VB
cord-346853-0c1qdjb5	135	27	the	the	DT
cord-346853-0c1qdjb5	135	28	chapter	chapter	NN
cord-346853-0c1qdjb5	135	29	by	by	IN
cord-346853-0c1qdjb5	135	30	Childs	Childs	NNP
cord-346853-0c1qdjb5	135	31	et	et	NNP
cord-346853-0c1qdjb5	135	32	al	al	NNP
cord-346853-0c1qdjb5	135	33	.	.	NNP
cord-346853-0c1qdjb5	135	34	,	,	,
cord-346853-0c1qdjb5	135	35	this	this	DT
cord-346853-0c1qdjb5	135	36	volume	volume	NN
cord-346853-0c1qdjb5	135	37	)	)	-RRB-
cord-346853-0c1qdjb5	135	38	.	.	.
cord-346853-0c1qdjb5	136	1	Perhaps	perhaps	RB
cord-346853-0c1qdjb5	136	2	the	the	DT
cord-346853-0c1qdjb5	136	3	central	central	JJ
cord-346853-0c1qdjb5	136	4	question	question	NN
cord-346853-0c1qdjb5	136	5	in	in	IN
cord-346853-0c1qdjb5	136	6	this	this	DT
cord-346853-0c1qdjb5	136	7	respect	respect	NN
cord-346853-0c1qdjb5	136	8	is	be	VBZ
cord-346853-0c1qdjb5	136	9	whether	whether	IN
cord-346853-0c1qdjb5	136	10	,	,	,
cord-346853-0c1qdjb5	136	11	following	follow	VBG
cord-346853-0c1qdjb5	136	12	cross	cross	JJ
cord-346853-0c1qdjb5	136	13	-	-	JJ
cord-346853-0c1qdjb5	136	14	species	species	JJ
cord-346853-0c1qdjb5	136	15	transmission	transmission	NN
cord-346853-0c1qdjb5	136	16	,	,	,
cord-346853-0c1qdjb5	136	17	emergent	emergent	JJ
cord-346853-0c1qdjb5	136	18	viruses	virus	NNS
cord-346853-0c1qdjb5	136	19	must	must	MD
cord-346853-0c1qdjb5	136	20	adapt	adapt	VB
cord-346853-0c1qdjb5	136	21	to	to	TO
cord-346853-0c1qdjb5	136	22	replicate	replicate	VB
cord-346853-0c1qdjb5	136	23	in	in	IN
cord-346853-0c1qdjb5	136	24	their	-PRON-	PRP$
cord-346853-0c1qdjb5	136	25	new	new	JJ
cord-346853-0c1qdjb5	136	26	species	specie	NNS
cord-346853-0c1qdjb5	136	27	,	,	,
cord-346853-0c1qdjb5	136	28	or	or	CC
cord-346853-0c1qdjb5	136	29	whether	whether	IN
cord-346853-0c1qdjb5	136	30	the	the	DT
cord-346853-0c1qdjb5	136	31	process	process	NN
cord-346853-0c1qdjb5	136	32	of	of	IN
cord-346853-0c1qdjb5	136	33	emergence	emergence	NN
cord-346853-0c1qdjb5	136	34	is	be	VBZ
cord-346853-0c1qdjb5	136	35	essentially	essentially	RB
cord-346853-0c1qdjb5	136	36	blind	blind	JJ
cord-346853-0c1qdjb5	136	37	to	to	IN
cord-346853-0c1qdjb5	136	38	natural	natural	JJ
cord-346853-0c1qdjb5	136	39	selection	selection	NN
cord-346853-0c1qdjb5	136	40	?	?	.
cord-346853-0c1qdjb5	137	1	Arguments	argument	NNS
cord-346853-0c1qdjb5	137	2	can	can	MD
cord-346853-0c1qdjb5	137	3	be	be	VB
cord-346853-0c1qdjb5	137	4	advanced	advance	VBN
cord-346853-0c1qdjb5	137	5	on	on	IN
cord-346853-0c1qdjb5	137	6	both	both	DT
cord-346853-0c1qdjb5	137	7	sides	side	NNS
cord-346853-0c1qdjb5	137	8	and	and	CC
cord-346853-0c1qdjb5	137	9	there	there	EX
cord-346853-0c1qdjb5	137	10	is	be	VBZ
cord-346853-0c1qdjb5	137	11	currently	currently	RB
cord-346853-0c1qdjb5	137	12	little	little	JJ
cord-346853-0c1qdjb5	137	13	good	good	JJ
cord-346853-0c1qdjb5	137	14	data	datum	NNS
cord-346853-0c1qdjb5	137	15	to	to	TO
cord-346853-0c1qdjb5	137	16	choose	choose	VB
cord-346853-0c1qdjb5	137	17	among	among	IN
cord-346853-0c1qdjb5	137	18	them	-PRON-	PRP
cord-346853-0c1qdjb5	137	19	.	.	.
cord-346853-0c1qdjb5	138	1	For	for	IN
cord-346853-0c1qdjb5	138	2	example	example	NN
cord-346853-0c1qdjb5	138	3	,	,	,
cord-346853-0c1qdjb5	138	4	one	one	CD
cord-346853-0c1qdjb5	138	5	model	model	NN
cord-346853-0c1qdjb5	138	6	of	of	IN
cord-346853-0c1qdjb5	138	7	viral	viral	JJ
cord-346853-0c1qdjb5	138	8	emergence	emergence	NN
cord-346853-0c1qdjb5	138	9	posits	posit	VBZ
cord-346853-0c1qdjb5	138	10	that	that	IN
cord-346853-0c1qdjb5	138	11	adaptation	adaptation	NN
cord-346853-0c1qdjb5	138	12	to	to	IN
cord-346853-0c1qdjb5	138	13	a	a	DT
cord-346853-0c1qdjb5	138	14	new	new	JJ
cord-346853-0c1qdjb5	138	15	host	host	NN
cord-346853-0c1qdjb5	138	16	species	specie	NNS
cord-346853-0c1qdjb5	138	17	during	during	IN
cord-346853-0c1qdjb5	138	18	the	the	DT
cord-346853-0c1qdjb5	138	19	early	early	JJ
cord-346853-0c1qdjb5	138	20	period	period	NN
cord-346853-0c1qdjb5	138	21	of	of	IN
cord-346853-0c1qdjb5	138	22	an	an	DT
cord-346853-0c1qdjb5	138	23	epidemic	epidemic	NN
cord-346853-0c1qdjb5	138	24	is	be	VBZ
cord-346853-0c1qdjb5	138	25	of	of	IN
cord-346853-0c1qdjb5	138	26	fundamental	fundamental	JJ
cord-346853-0c1qdjb5	138	27	importance	importance	NN
cord-346853-0c1qdjb5	138	28	,	,	,
cord-346853-0c1qdjb5	138	29	because	because	IN
cord-346853-0c1qdjb5	138	30	this	this	DT
cord-346853-0c1qdjb5	138	31	raises	raise	VBZ
cord-346853-0c1qdjb5	138	32	the	the	DT
cord-346853-0c1qdjb5	138	33	basic	basic	JJ
cord-346853-0c1qdjb5	138	34	reproductive	reproductive	JJ
cord-346853-0c1qdjb5	138	35	rate	rate	NN
cord-346853-0c1qdjb5	138	36	of	of	IN
cord-346853-0c1qdjb5	138	37	the	the	DT
cord-346853-0c1qdjb5	138	38	virus	virus	NN
cord-346853-0c1qdjb5	138	39	,	,	,
cord-346853-0c1qdjb5	138	40	R	r	NN
cord-346853-0c1qdjb5	138	41	0	0	CD
cord-346853-0c1qdjb5	138	42	,	,	,
cord-346853-0c1qdjb5	138	43	to	to	IN
cord-346853-0c1qdjb5	138	44	greater	great	JJR
cord-346853-0c1qdjb5	138	45	than	than	IN
cord-346853-0c1qdjb5	138	46	1	1	CD
cord-346853-0c1qdjb5	138	47	,	,	,
cord-346853-0c1qdjb5	138	48	so	so	IN
cord-346853-0c1qdjb5	138	49	that	that	IN
cord-346853-0c1qdjb5	138	50	sustained	sustained	JJ
cord-346853-0c1qdjb5	138	51	transmission	transmission	NN
cord-346853-0c1qdjb5	138	52	networks	network	NNS
cord-346853-0c1qdjb5	138	53	can	can	MD
cord-346853-0c1qdjb5	138	54	be	be	VB
cord-346853-0c1qdjb5	138	55	established	establish	VBN
cord-346853-0c1qdjb5	139	1	(	(	-LRB-
cord-346853-0c1qdjb5	139	2	Anita	Anita	NNP
cord-346853-0c1qdjb5	139	3	et	et	NNP
cord-346853-0c1qdjb5	139	4	al	al	NNP
cord-346853-0c1qdjb5	139	5	.	.	NNP
cord-346853-0c1qdjb5	139	6	2003	2003	CD
cord-346853-0c1qdjb5	139	7	)	)	-RRB-
cord-346853-0c1qdjb5	139	8	.	.	.
cord-346853-0c1qdjb5	140	1	This	this	DT
cord-346853-0c1qdjb5	140	2	adaptive	adaptive	JJ
cord-346853-0c1qdjb5	140	3	process	process	NN
cord-346853-0c1qdjb5	140	4	is	be	VBZ
cord-346853-0c1qdjb5	140	5	thought	think	VBN
cord-346853-0c1qdjb5	140	6	to	to	TO
cord-346853-0c1qdjb5	140	7	occur	occur	VB
cord-346853-0c1qdjb5	140	8	during	during	IN
cord-346853-0c1qdjb5	140	9	the	the	DT
cord-346853-0c1qdjb5	140	10	"	"	``
cord-346853-0c1qdjb5	140	11	stuttering	stutter	VBG
cord-346853-0c1qdjb5	140	12	chains	chain	NNS
cord-346853-0c1qdjb5	140	13	of	of	IN
cord-346853-0c1qdjb5	140	14	transmission	transmission	NN
cord-346853-0c1qdjb5	140	15	"	"	''
cord-346853-0c1qdjb5	140	16	that	that	WDT
cord-346853-0c1qdjb5	140	17	might	may	MD
cord-346853-0c1qdjb5	140	18	characterize	characterize	VB
cord-346853-0c1qdjb5	140	19	the	the	DT
cord-346853-0c1qdjb5	140	20	early	early	JJ
cord-346853-0c1qdjb5	140	21	stages	stage	NNS
cord-346853-0c1qdjb5	140	22	of	of	IN
cord-346853-0c1qdjb5	140	23	an	an	DT
cord-346853-0c1qdjb5	140	24	epidemic	epidemic	NN
cord-346853-0c1qdjb5	141	1	(	(	-LRB-
cord-346853-0c1qdjb5	141	2	Anita	Anita	NNP
cord-346853-0c1qdjb5	141	3	et	et	NNP
cord-346853-0c1qdjb5	141	4	al	al	NNP
cord-346853-0c1qdjb5	141	5	.	.	NNP
cord-346853-0c1qdjb5	141	6	2003	2003	CD
cord-346853-0c1qdjb5	141	7	)	)	-RRB-
cord-346853-0c1qdjb5	141	8	.	.	.
cord-346853-0c1qdjb5	142	1	Hence	hence	RB
cord-346853-0c1qdjb5	142	2	,	,	,
cord-346853-0c1qdjb5	142	3	those	those	DT
cord-346853-0c1qdjb5	142	4	viruses	virus	NNS
cord-346853-0c1qdjb5	142	5	that	that	WDT
cord-346853-0c1qdjb5	142	6	have	have	VBP
cord-346853-0c1qdjb5	142	7	not	not	RB
cord-346853-0c1qdjb5	142	8	evolved	evolve	VBN
cord-346853-0c1qdjb5	142	9	humanto	humanto	JJ
cord-346853-0c1qdjb5	142	10	-	-	HYPH
cord-346853-0c1qdjb5	142	11	human	human	JJ
cord-346853-0c1qdjb5	142	12	transmission	transmission	NN
cord-346853-0c1qdjb5	142	13	are	be	VBP
cord-346853-0c1qdjb5	142	14	simply	simply	RB
cord-346853-0c1qdjb5	142	15	those	those	DT
cord-346853-0c1qdjb5	142	16	that	that	WDT
cord-346853-0c1qdjb5	142	17	have	have	VBP
cord-346853-0c1qdjb5	142	18	not	not	RB
cord-346853-0c1qdjb5	142	19	yet	yet	RB
cord-346853-0c1qdjb5	142	20	fully	fully	RB
cord-346853-0c1qdjb5	142	21	adapted	adapt	VBN
cord-346853-0c1qdjb5	142	22	to	to	IN
cord-346853-0c1qdjb5	142	23	our	-PRON-	PRP$
cord-346853-0c1qdjb5	142	24	species	specie	NNS
cord-346853-0c1qdjb5	142	25	as	as	IN
cord-346853-0c1qdjb5	142	26	R	r	NN
cord-346853-0c1qdjb5	142	27	0	0	CD
cord-346853-0c1qdjb5	142	28	<	<	XX
cord-346853-0c1qdjb5	142	29	1	1	CD
cord-346853-0c1qdjb5	142	30	(	(	-LRB-
cord-346853-0c1qdjb5	142	31	and	and	CC
cord-346853-0c1qdjb5	142	32	human	human	NN
cord-346853-0c1qdjb5	142	33	-	-	HYPH
cord-346853-0c1qdjb5	142	34	to	to	IN
cord-346853-0c1qdjb5	142	35	-	-	HYPH
cord-346853-0c1qdjb5	142	36	human	human	JJ
cord-346853-0c1qdjb5	142	37	transmission	transmission	NN
cord-346853-0c1qdjb5	142	38	would	would	MD
cord-346853-0c1qdjb5	142	39	surely	surely	RB
cord-346853-0c1qdjb5	142	40	be	be	VB
cord-346853-0c1qdjb5	142	41	favored	favor	VBN
cord-346853-0c1qdjb5	142	42	by	by	IN
cord-346853-0c1qdjb5	142	43	natural	natural	JJ
cord-346853-0c1qdjb5	142	44	selection	selection	NN
cord-346853-0c1qdjb5	142	45	because	because	IN
cord-346853-0c1qdjb5	142	46	it	-PRON-	PRP
cord-346853-0c1qdjb5	142	47	increases	increase	VBZ
cord-346853-0c1qdjb5	142	48	the	the	DT
cord-346853-0c1qdjb5	142	49	number	number	NN
cord-346853-0c1qdjb5	142	50	of	of	IN
cord-346853-0c1qdjb5	142	51	secondary	secondary	JJ
cord-346853-0c1qdjb5	142	52	infections	infection	NNS
cord-346853-0c1qdjb5	142	53	)	)	-RRB-
cord-346853-0c1qdjb5	142	54	.	.	.
cord-346853-0c1qdjb5	143	1	Empirical	empirical	JJ
cord-346853-0c1qdjb5	143	2	evidence	evidence	NN
cord-346853-0c1qdjb5	143	3	for	for	IN
cord-346853-0c1qdjb5	143	4	this	this	DT
cord-346853-0c1qdjb5	143	5	theory	theory	NN
cord-346853-0c1qdjb5	143	6	comes	come	VBZ
cord-346853-0c1qdjb5	143	7	from	from	IN
cord-346853-0c1qdjb5	143	8	one	one	CD
cord-346853-0c1qdjb5	143	9	of	of	IN
cord-346853-0c1qdjb5	143	10	the	the	DT
cord-346853-0c1qdjb5	143	11	best	well	RBS
cord-346853-0c1qdjb5	143	12	-	-	HYPH
cord-346853-0c1qdjb5	143	13	documented	document	VBN
cord-346853-0c1qdjb5	143	14	cases	case	NNS
cord-346853-0c1qdjb5	143	15	of	of	IN
cord-346853-0c1qdjb5	143	16	emergence	emergence	NN
cord-346853-0c1qdjb5	143	17	,	,	,
cord-346853-0c1qdjb5	143	18	that	that	DT
cord-346853-0c1qdjb5	143	19	of	of	IN
cord-346853-0c1qdjb5	143	20	the	the	DT
cord-346853-0c1qdjb5	143	21	carnivore	carnivore	NN
cord-346853-0c1qdjb5	143	22	parvoviruses	parvovirus	NNS
cord-346853-0c1qdjb5	143	23	(	(	-LRB-
cord-346853-0c1qdjb5	143	24	ssDNA	ssdna	NN
cord-346853-0c1qdjb5	143	25	viruses	virus	NNS
cord-346853-0c1qdjb5	143	26	)	)	-RRB-
cord-346853-0c1qdjb5	143	27	.	.	.
cord-346853-0c1qdjb5	144	1	In	in	IN
cord-346853-0c1qdjb5	144	2	this	this	DT
cord-346853-0c1qdjb5	144	3	case	case	NN
cord-346853-0c1qdjb5	144	4	,	,	,
cord-346853-0c1qdjb5	144	5	the	the	DT
cord-346853-0c1qdjb5	144	6	feline	feline	JJ
cord-346853-0c1qdjb5	144	7	parvoviruses	parvovirus	NNS
cord-346853-0c1qdjb5	144	8	that	that	WDT
cord-346853-0c1qdjb5	144	9	infected	infected	JJ
cord-346853-0c1qdjb5	144	10	cats	cat	NNS
cord-346853-0c1qdjb5	144	11	jumped	jump	VBD
cord-346853-0c1qdjb5	144	12	to	to	IN
cord-346853-0c1qdjb5	144	13	dogs	dog	NNS
cord-346853-0c1qdjb5	144	14	in	in	IN
cord-346853-0c1qdjb5	144	15	the	the	DT
cord-346853-0c1qdjb5	144	16	early	early	JJ
cord-346853-0c1qdjb5	144	17	1970s	1970	NNS
cord-346853-0c1qdjb5	144	18	,	,	,
cord-346853-0c1qdjb5	144	19	therein	therein	RB
cord-346853-0c1qdjb5	144	20	giving	give	VBG
cord-346853-0c1qdjb5	144	21	rise	rise	NN
cord-346853-0c1qdjb5	144	22	to	to	IN
cord-346853-0c1qdjb5	144	23	the	the	DT
cord-346853-0c1qdjb5	144	24	canine	canine	JJ
cord-346853-0c1qdjb5	144	25	parvoviruses	parvovirus	NNS
cord-346853-0c1qdjb5	144	26	,	,	,
cord-346853-0c1qdjb5	144	27	an	an	DT
cord-346853-0c1qdjb5	144	28	event	event	NN
cord-346853-0c1qdjb5	144	29	that	that	WDT
cord-346853-0c1qdjb5	144	30	was	be	VBD
cord-346853-0c1qdjb5	144	31	accompanied	accompany	VBN
cord-346853-0c1qdjb5	144	32	by	by	IN
cord-346853-0c1qdjb5	144	33	strong	strong	JJ
cord-346853-0c1qdjb5	144	34	positive	positive	JJ
cord-346853-0c1qdjb5	144	35	selection	selection	NN
cord-346853-0c1qdjb5	144	36	and	and	CC
cord-346853-0c1qdjb5	144	37	an	an	DT
cord-346853-0c1qdjb5	144	38	extremely	extremely	RB
cord-346853-0c1qdjb5	144	39	high	high	JJ
cord-346853-0c1qdjb5	144	40	rate	rate	NN
cord-346853-0c1qdjb5	144	41	of	of	IN
cord-346853-0c1qdjb5	144	42	nucleotide	nucleotide	JJ
cord-346853-0c1qdjb5	144	43	substitution	substitution	NN
cord-346853-0c1qdjb5	144	44	(	(	-LRB-
cord-346853-0c1qdjb5	144	45	Shackelton	Shackelton	NNP
cord-346853-0c1qdjb5	144	46	et	et	FW
cord-346853-0c1qdjb5	144	47	al	al	NNP
cord-346853-0c1qdjb5	144	48	.	.	NNP
cord-346853-0c1qdjb5	144	49	2005	2005	CD
cord-346853-0c1qdjb5	144	50	)	)	-RRB-
cord-346853-0c1qdjb5	144	51	.	.	.
cord-346853-0c1qdjb5	145	1	Direct	direct	JJ
cord-346853-0c1qdjb5	145	2	adaptation	adaptation	NN
cord-346853-0c1qdjb5	145	3	to	to	IN
cord-346853-0c1qdjb5	145	4	a	a	DT
cord-346853-0c1qdjb5	145	5	new	new	JJ
cord-346853-0c1qdjb5	145	6	host	host	NN
cord-346853-0c1qdjb5	145	7	species	specie	NNS
cord-346853-0c1qdjb5	145	8	also	also	RB
cord-346853-0c1qdjb5	145	9	seems	seem	VBZ
cord-346853-0c1qdjb5	145	10	to	to	TO
cord-346853-0c1qdjb5	145	11	have	have	VB
cord-346853-0c1qdjb5	145	12	been	be	VBN
cord-346853-0c1qdjb5	145	13	central	central	JJ
cord-346853-0c1qdjb5	145	14	to	to	IN
cord-346853-0c1qdjb5	145	15	the	the	DT
cord-346853-0c1qdjb5	145	16	emergence	emergence	NN
cord-346853-0c1qdjb5	145	17	of	of	IN
cord-346853-0c1qdjb5	145	18	the	the	DT
cord-346853-0c1qdjb5	145	19	Venezuelan	venezuelan	JJ
cord-346853-0c1qdjb5	145	20	equine	equine	NN
cord-346853-0c1qdjb5	145	21	encephalitis	encephalitis	NN
cord-346853-0c1qdjb5	145	22	virus	virus	NN
cord-346853-0c1qdjb5	145	23	(	(	-LRB-
cord-346853-0c1qdjb5	145	24	Brault	Brault	NNP
cord-346853-0c1qdjb5	145	25	et	et	FW
cord-346853-0c1qdjb5	145	26	al	al	NNP
cord-346853-0c1qdjb5	145	27	.	.	.
cord-346853-0c1qdjb5	145	28	2002	2002	CD
cord-346853-0c1qdjb5	145	29	)	)	-RRB-
cord-346853-0c1qdjb5	145	30	.	.	.
cord-346853-0c1qdjb5	146	1	Further	further	RB
cord-346853-0c1qdjb5	146	2	,	,	,
cord-346853-0c1qdjb5	146	3	although	although	IN
cord-346853-0c1qdjb5	146	4	there	there	EX
cord-346853-0c1qdjb5	146	5	is	be	VBZ
cord-346853-0c1qdjb5	146	6	no	no	DT
cord-346853-0c1qdjb5	146	7	strong	strong	JJ
cord-346853-0c1qdjb5	146	8	evidence	evidence	NN
cord-346853-0c1qdjb5	146	9	to	to	IN
cord-346853-0c1qdjb5	146	10	date	date	NN
cord-346853-0c1qdjb5	146	11	that	that	IN
cord-346853-0c1qdjb5	146	12	the	the	DT
cord-346853-0c1qdjb5	146	13	cross	cross	NN
cord-346853-0c1qdjb5	146	14	-	-	JJ
cord-346853-0c1qdjb5	146	15	species	species	JJ
cord-346853-0c1qdjb5	146	16	transmission	transmission	NN
cord-346853-0c1qdjb5	146	17	event	event	NN
cord-346853-0c1qdjb5	146	18	from	from	IN
cord-346853-0c1qdjb5	146	19	dengue	dengue	NN
cord-346853-0c1qdjb5	146	20	virus	virus	NN
cord-346853-0c1qdjb5	146	21	in	in	IN
cord-346853-0c1qdjb5	146	22	monkeys	monkey	NNS
cord-346853-0c1qdjb5	146	23	to	to	IN
cord-346853-0c1qdjb5	146	24	dengue	dengue	NN
cord-346853-0c1qdjb5	146	25	virus	virus	NN
cord-346853-0c1qdjb5	146	26	in	in	IN
cord-346853-0c1qdjb5	146	27	humans	human	NNS
cord-346853-0c1qdjb5	146	28	involved	involve	VBD
cord-346853-0c1qdjb5	146	29	adaptive	adaptive	JJ
cord-346853-0c1qdjb5	146	30	evolution	evolution	NN
cord-346853-0c1qdjb5	146	31	in	in	IN
cord-346853-0c1qdjb5	146	32	the	the	DT
cord-346853-0c1qdjb5	146	33	latter	latter	JJ
cord-346853-0c1qdjb5	146	34	(	(	-LRB-
cord-346853-0c1qdjb5	146	35	Twiddy	Twiddy	NNP
cord-346853-0c1qdjb5	146	36	et	et	NNP
cord-346853-0c1qdjb5	146	37	al	al	NNP
cord-346853-0c1qdjb5	146	38	.	.	.
cord-346853-0c1qdjb5	146	39	2002	2002	CD
cord-346853-0c1qdjb5	146	40	)	)	-RRB-
cord-346853-0c1qdjb5	146	41	,	,	,
cord-346853-0c1qdjb5	146	42	experimental	experimental	JJ
cord-346853-0c1qdjb5	146	43	studies	study	NNS
cord-346853-0c1qdjb5	146	44	imply	imply	VBP
cord-346853-0c1qdjb5	146	45	that	that	IN
cord-346853-0c1qdjb5	146	46	adaptation	adaptation	NN
cord-346853-0c1qdjb5	146	47	to	to	IN
cord-346853-0c1qdjb5	146	48	the	the	DT
cord-346853-0c1qdjb5	146	49	principal	principal	JJ
cord-346853-0c1qdjb5	146	50	vector	vector	NN
cord-346853-0c1qdjb5	146	51	of	of	IN
cord-346853-0c1qdjb5	146	52	dengue	dengue	NN
cord-346853-0c1qdjb5	146	53	virus	virus	NN
cord-346853-0c1qdjb5	146	54	in	in	IN
cord-346853-0c1qdjb5	146	55	an	an	DT
cord-346853-0c1qdjb5	146	56	urban	urban	JJ
cord-346853-0c1qdjb5	146	57	human	human	NN
cord-346853-0c1qdjb5	146	58	setting	setting	NN
cord-346853-0c1qdjb5	146	59	,	,	,
cord-346853-0c1qdjb5	146	60	the	the	DT
cord-346853-0c1qdjb5	146	61	Aedes	Aedes	NNP
cord-346853-0c1qdjb5	146	62	aegypti	aegypti	NN
cord-346853-0c1qdjb5	146	63	mosquito	mosquito	NN
cord-346853-0c1qdjb5	146	64	,	,	,
cord-346853-0c1qdjb5	146	65	is	be	VBZ
cord-346853-0c1qdjb5	146	66	a	a	DT
cord-346853-0c1qdjb5	146	67	crucial	crucial	JJ
cord-346853-0c1qdjb5	146	68	prerequisite	prerequisite	NN
cord-346853-0c1qdjb5	146	69	for	for	IN
cord-346853-0c1qdjb5	146	70	sustained	sustained	JJ
cord-346853-0c1qdjb5	146	71	human	human	JJ
cord-346853-0c1qdjb5	146	72	transmission	transmission	NN
cord-346853-0c1qdjb5	147	1	(	(	-LRB-
cord-346853-0c1qdjb5	147	2	Moncayo	Moncayo	NNP
cord-346853-0c1qdjb5	147	3	et	et	NNP
cord-346853-0c1qdjb5	147	4	al	al	NNP
cord-346853-0c1qdjb5	147	5	.	.	.
cord-346853-0c1qdjb5	147	6	2004	2004	CD
cord-346853-0c1qdjb5	147	7	)	)	-RRB-
cord-346853-0c1qdjb5	147	8	.	.	.
cord-346853-0c1qdjb5	148	1	An	an	DT
cord-346853-0c1qdjb5	148	2	alternative	alternative	JJ
cord-346853-0c1qdjb5	148	3	model	model	NN
cord-346853-0c1qdjb5	148	4	for	for	IN
cord-346853-0c1qdjb5	148	5	viral	viral	JJ
cord-346853-0c1qdjb5	148	6	emergence	emergence	NN
cord-346853-0c1qdjb5	148	7	is	be	VBZ
cord-346853-0c1qdjb5	148	8	that	that	DT
cord-346853-0c1qdjb5	148	9	rather	rather	RB
cord-346853-0c1qdjb5	148	10	than	than	IN
cord-346853-0c1qdjb5	148	11	the	the	DT
cord-346853-0c1qdjb5	148	12	emergent	emergent	JJ
cord-346853-0c1qdjb5	148	13	virus	virus	NN
cord-346853-0c1qdjb5	148	14	adapting	adapt	VBG
cord-346853-0c1qdjb5	148	15	to	to	IN
cord-346853-0c1qdjb5	148	16	the	the	DT
cord-346853-0c1qdjb5	148	17	new	new	JJ
cord-346853-0c1qdjb5	148	18	host	host	NN
cord-346853-0c1qdjb5	148	19	species	species	NN
cord-346853-0c1qdjb5	148	20	following	follow	VBG
cord-346853-0c1qdjb5	148	21	exposure	exposure	NN
cord-346853-0c1qdjb5	148	22	,	,	,
cord-346853-0c1qdjb5	148	23	successful	successful	JJ
cord-346853-0c1qdjb5	148	24	emergence	emergence	NN
cord-346853-0c1qdjb5	148	25	will	will	MD
cord-346853-0c1qdjb5	148	26	only	only	RB
cord-346853-0c1qdjb5	148	27	occur	occur	VB
cord-346853-0c1qdjb5	148	28	if	if	IN
cord-346853-0c1qdjb5	148	29	a	a	DT
cord-346853-0c1qdjb5	148	30	virus	virus	NN
cord-346853-0c1qdjb5	148	31	that	that	WDT
cord-346853-0c1qdjb5	148	32	already	already	RB
cord-346853-0c1qdjb5	148	33	possesses	possess	VBZ
cord-346853-0c1qdjb5	148	34	the	the	DT
cord-346853-0c1qdjb5	148	35	necessary	necessary	JJ
cord-346853-0c1qdjb5	148	36	mutations	mutation	NNS
cord-346853-0c1qdjb5	148	37	(	(	-LRB-
cord-346853-0c1qdjb5	148	38	such	such	JJ
cord-346853-0c1qdjb5	148	39	as	as	IN
cord-346853-0c1qdjb5	148	40	those	those	DT
cord-346853-0c1qdjb5	148	41	for	for	IN
cord-346853-0c1qdjb5	148	42	receptor	receptor	NN
cord-346853-0c1qdjb5	148	43	-	-	HYPH
cord-346853-0c1qdjb5	148	44	binding	binding	NN
cord-346853-0c1qdjb5	148	45	)	)	-RRB-
cord-346853-0c1qdjb5	148	46	is	be	VBZ
cord-346853-0c1qdjb5	148	47	exposed	expose	VBN
cord-346853-0c1qdjb5	148	48	to	to	IN
cord-346853-0c1qdjb5	148	49	the	the	DT
cord-346853-0c1qdjb5	148	50	recipient	recipient	NN
cord-346853-0c1qdjb5	148	51	host	host	NN
cord-346853-0c1qdjb5	148	52	.	.	.
cord-346853-0c1qdjb5	149	1	In	in	IN
cord-346853-0c1qdjb5	149	2	other	other	JJ
cord-346853-0c1qdjb5	149	3	words	word	NNS
cord-346853-0c1qdjb5	149	4	,	,	,
cord-346853-0c1qdjb5	149	5	successful	successful	JJ
cord-346853-0c1qdjb5	149	6	emergent	emergent	JJ
cord-346853-0c1qdjb5	149	7	strains	strain	NNS
cord-346853-0c1qdjb5	149	8	are	be	VBP
cord-346853-0c1qdjb5	149	9	those	those	DT
cord-346853-0c1qdjb5	149	10	that	that	WDT
cord-346853-0c1qdjb5	149	11	are	be	VBP
cord-346853-0c1qdjb5	149	12	in	in	IN
cord-346853-0c1qdjb5	149	13	some	some	DT
cord-346853-0c1qdjb5	149	14	sense	sense	NN
cord-346853-0c1qdjb5	149	15	preadapted	preadapte	VBN
cord-346853-0c1qdjb5	149	16	to	to	TO
cord-346853-0c1qdjb5	149	17	establish	establish	VB
cord-346853-0c1qdjb5	149	18	productive	productive	JJ
cord-346853-0c1qdjb5	149	19	infections	infection	NNS
cord-346853-0c1qdjb5	149	20	in	in	IN
cord-346853-0c1qdjb5	149	21	the	the	DT
cord-346853-0c1qdjb5	149	22	new	new	JJ
cord-346853-0c1qdjb5	149	23	host	host	NN
cord-346853-0c1qdjb5	149	24	species	specie	NNS
cord-346853-0c1qdjb5	149	25	(	(	-LRB-
cord-346853-0c1qdjb5	149	26	see	see	VB
cord-346853-0c1qdjb5	149	27	the	the	DT
cord-346853-0c1qdjb5	149	28	chapter	chapter	NN
cord-346853-0c1qdjb5	149	29	by	by	IN
cord-346853-0c1qdjb5	149	30	Childs	Childs	NNP
cord-346853-0c1qdjb5	149	31	et	et	NNP
cord-346853-0c1qdjb5	149	32	al	al	NNP
cord-346853-0c1qdjb5	149	33	.	.	NNP
cord-346853-0c1qdjb5	149	34	,	,	,
cord-346853-0c1qdjb5	149	35	this	this	DT
cord-346853-0c1qdjb5	149	36	volume	volume	NN
cord-346853-0c1qdjb5	149	37	)	)	-RRB-
cord-346853-0c1qdjb5	149	38	,	,	,
cord-346853-0c1qdjb5	149	39	so	so	IN
cord-346853-0c1qdjb5	149	40	that	that	IN
cord-346853-0c1qdjb5	149	41	the	the	DT
cord-346853-0c1qdjb5	149	42	probability	probability	NN
cord-346853-0c1qdjb5	149	43	of	of	IN
cord-346853-0c1qdjb5	149	44	emergence	emergence	NN
cord-346853-0c1qdjb5	149	45	then	then	RB
cord-346853-0c1qdjb5	149	46	becomes	become	VBZ
cord-346853-0c1qdjb5	149	47	a	a	DT
cord-346853-0c1qdjb5	149	48	function	function	NN
cord-346853-0c1qdjb5	149	49	of	of	IN
cord-346853-0c1qdjb5	149	50	the	the	DT
cord-346853-0c1qdjb5	149	51	frequency	frequency	NN
cord-346853-0c1qdjb5	149	52	of	of	IN
cord-346853-0c1qdjb5	149	53	exposure	exposure	NN
cord-346853-0c1qdjb5	149	54	.	.	.
cord-346853-0c1qdjb5	150	1	Indeed	indeed	RB
cord-346853-0c1qdjb5	150	2	,	,	,
cord-346853-0c1qdjb5	150	3	that	that	IN
cord-346853-0c1qdjb5	150	4	the	the	DT
cord-346853-0c1qdjb5	150	5	majority	majority	NN
cord-346853-0c1qdjb5	150	6	of	of	IN
cord-346853-0c1qdjb5	150	7	emerging	emerge	VBG
cord-346853-0c1qdjb5	150	8	infections	infection	NNS
cord-346853-0c1qdjb5	150	9	(	(	-LRB-
cord-346853-0c1qdjb5	150	10	in	in	IN
cord-346853-0c1qdjb5	150	11	humans	human	NNS
cord-346853-0c1qdjb5	150	12	at	at	IN
cord-346853-0c1qdjb5	150	13	least	least	JJS
cord-346853-0c1qdjb5	150	14	)	)	-RRB-
cord-346853-0c1qdjb5	150	15	result	result	VB
cord-346853-0c1qdjb5	150	16	in	in	IN
cord-346853-0c1qdjb5	150	17	dead	dead	JJ
cord-346853-0c1qdjb5	150	18	-	-	HYPH
cord-346853-0c1qdjb5	150	19	end	end	NN
cord-346853-0c1qdjb5	150	20	infections	infection	NNS
cord-346853-0c1qdjb5	150	21	implies	imply	VBZ
cord-346853-0c1qdjb5	150	22	that	that	IN
cord-346853-0c1qdjb5	150	23	even	even	RB
cord-346853-0c1qdjb5	150	24	short	short	JJ
cord-346853-0c1qdjb5	150	25	-	-	HYPH
cord-346853-0c1qdjb5	150	26	term	term	NN
cord-346853-0c1qdjb5	150	27	transmission	transmission	NN
cord-346853-0c1qdjb5	150	28	chains	chain	NNS
cord-346853-0c1qdjb5	150	29	are	be	VBP
cord-346853-0c1qdjb5	150	30	difficult	difficult	JJ
cord-346853-0c1qdjb5	150	31	to	to	TO
cord-346853-0c1qdjb5	150	32	establish	establish	VB
cord-346853-0c1qdjb5	150	33	for	for	IN
cord-346853-0c1qdjb5	150	34	most	most	JJS
cord-346853-0c1qdjb5	150	35	viruses	virus	NNS
cord-346853-0c1qdjb5	150	36	because	because	IN
cord-346853-0c1qdjb5	150	37	they	-PRON-	PRP
cord-346853-0c1qdjb5	150	38	lack	lack	VBP
cord-346853-0c1qdjb5	150	39	the	the	DT
cord-346853-0c1qdjb5	150	40	necessary	necessary	JJ
cord-346853-0c1qdjb5	150	41	mutations	mutation	NNS
cord-346853-0c1qdjb5	150	42	.	.	.
cord-346853-0c1qdjb5	151	1	Moreover	moreover	RB
cord-346853-0c1qdjb5	151	2	,	,	,
cord-346853-0c1qdjb5	151	3	for	for	IN
cord-346853-0c1qdjb5	151	4	the	the	DT
cord-346853-0c1qdjb5	151	5	majority	majority	NN
cord-346853-0c1qdjb5	151	6	of	of	IN
cord-346853-0c1qdjb5	151	7	emergent	emergent	JJ
cord-346853-0c1qdjb5	151	8	viruses	virus	NNS
cord-346853-0c1qdjb5	151	9	it	-PRON-	PRP
cord-346853-0c1qdjb5	151	10	has	have	VBZ
cord-346853-0c1qdjb5	151	11	been	be	VBN
cord-346853-0c1qdjb5	151	12	difficult	difficult	JJ
cord-346853-0c1qdjb5	151	13	to	to	TO
cord-346853-0c1qdjb5	151	14	show	show	VB
cord-346853-0c1qdjb5	151	15	that	that	IN
cord-346853-0c1qdjb5	151	16	cross	cross	NN
cord-346853-0c1qdjb5	151	17	-	-	JJ
cord-346853-0c1qdjb5	151	18	species	species	JJ
cord-346853-0c1qdjb5	151	19	transmission	transmission	NN
cord-346853-0c1qdjb5	151	20	is	be	VBZ
cord-346853-0c1qdjb5	151	21	associated	associate	VBN
cord-346853-0c1qdjb5	151	22	with	with	IN
cord-346853-0c1qdjb5	151	23	adaptation	adaptation	NN
cord-346853-0c1qdjb5	151	24	in	in	IN
cord-346853-0c1qdjb5	151	25	the	the	DT
cord-346853-0c1qdjb5	151	26	recipient	recipient	NN
cord-346853-0c1qdjb5	151	27	host	host	NN
cord-346853-0c1qdjb5	151	28	.	.	.
cord-346853-0c1qdjb5	152	1	To	to	TO
cord-346853-0c1qdjb5	152	2	take	take	VB
cord-346853-0c1qdjb5	152	3	two	two	CD
cord-346853-0c1qdjb5	152	4	high	high	JJ
cord-346853-0c1qdjb5	152	5	-	-	HYPH
cord-346853-0c1qdjb5	152	6	profile	profile	NN
cord-346853-0c1qdjb5	152	7	examples	example	NNS
cord-346853-0c1qdjb5	152	8	,	,	,
cord-346853-0c1qdjb5	152	9	although	although	IN
cord-346853-0c1qdjb5	152	10	some	some	DT
cord-346853-0c1qdjb5	152	11	sequence	sequence	NN
cord-346853-0c1qdjb5	152	12	analyses	analysis	NNS
cord-346853-0c1qdjb5	152	13	suggest	suggest	VBP
cord-346853-0c1qdjb5	152	14	that	that	IN
cord-346853-0c1qdjb5	152	15	SARS	SARS	NNP
cord-346853-0c1qdjb5	152	16	-	-	HYPH
cord-346853-0c1qdjb5	152	17	CoV	CoV	NNP
cord-346853-0c1qdjb5	152	18	was	be	VBD
cord-346853-0c1qdjb5	152	19	subject	subject	JJ
cord-346853-0c1qdjb5	152	20	to	to	IN
cord-346853-0c1qdjb5	152	21	adaptive	adaptive	JJ
cord-346853-0c1qdjb5	152	22	evolution	evolution	NN
cord-346853-0c1qdjb5	152	23	during	during	IN
cord-346853-0c1qdjb5	152	24	its	-PRON-	PRP$
cord-346853-0c1qdjb5	152	25	early	early	JJ
cord-346853-0c1qdjb5	152	26	spread	spread	NN
cord-346853-0c1qdjb5	152	27	through	through	IN
cord-346853-0c1qdjb5	152	28	humans	human	NNS
cord-346853-0c1qdjb5	153	1	(	(	-LRB-
cord-346853-0c1qdjb5	153	2	Yeh	Yeh	NNP
cord-346853-0c1qdjb5	153	3	et	et	NNP
cord-346853-0c1qdjb5	153	4	al	al	NNP
cord-346853-0c1qdjb5	153	5	.	.	.
cord-346853-0c1qdjb5	153	6	2004	2004	CD
cord-346853-0c1qdjb5	153	7	)	)	-RRB-
cord-346853-0c1qdjb5	154	1	,	,	,
cord-346853-0c1qdjb5	154	2	it	-PRON-	PRP
cord-346853-0c1qdjb5	154	3	is	be	VBZ
cord-346853-0c1qdjb5	154	4	unclear	unclear	JJ
cord-346853-0c1qdjb5	154	5	whether	whether	IN
cord-346853-0c1qdjb5	154	6	this	this	DT
cord-346853-0c1qdjb5	154	7	was	be	VBD
cord-346853-0c1qdjb5	154	8	adaptation	adaptation	NN
cord-346853-0c1qdjb5	154	9	to	to	IN
cord-346853-0c1qdjb5	154	10	the	the	DT
cord-346853-0c1qdjb5	154	11	new	new	JJ
cord-346853-0c1qdjb5	154	12	host	host	NN
cord-346853-0c1qdjb5	154	13	or	or	CC
cord-346853-0c1qdjb5	154	14	selection	selection	NN
cord-346853-0c1qdjb5	154	15	for	for	IN
cord-346853-0c1qdjb5	154	16	immune	immune	JJ
cord-346853-0c1qdjb5	154	17	escape	escape	NN
cord-346853-0c1qdjb5	154	18	.	.	.
cord-346853-0c1qdjb5	155	1	Similarly	similarly	RB
cord-346853-0c1qdjb5	155	2	,	,	,
cord-346853-0c1qdjb5	155	3	while	while	IN
cord-346853-0c1qdjb5	155	4	the	the	DT
cord-346853-0c1qdjb5	155	5	transition	transition	NN
cord-346853-0c1qdjb5	155	6	from	from	IN
cord-346853-0c1qdjb5	155	7	SIVcpz	SIVcpz	NNP
cord-346853-0c1qdjb5	155	8	in	in	IN
cord-346853-0c1qdjb5	155	9	chimpanzees	chimpanzee	NNS
cord-346853-0c1qdjb5	155	10	to	to	IN
cord-346853-0c1qdjb5	155	11	HIV	HIV	NNP
cord-346853-0c1qdjb5	155	12	in	in	IN
cord-346853-0c1qdjb5	155	13	humans	human	NNS
cord-346853-0c1qdjb5	155	14	seems	seem	VBZ
cord-346853-0c1qdjb5	155	15	to	to	TO
cord-346853-0c1qdjb5	155	16	have	have	VB
cord-346853-0c1qdjb5	155	17	been	be	VBN
cord-346853-0c1qdjb5	155	18	associated	associate	VBN
cord-346853-0c1qdjb5	155	19	with	with	IN
cord-346853-0c1qdjb5	155	20	a	a	DT
cord-346853-0c1qdjb5	155	21	change	change	NN
cord-346853-0c1qdjb5	155	22	in	in	IN
cord-346853-0c1qdjb5	155	23	selection	selection	NN
cord-346853-0c1qdjb5	155	24	pressure	pressure	NN
cord-346853-0c1qdjb5	155	25	(	(	-LRB-
cord-346853-0c1qdjb5	155	26	Sharp	Sharp	NNP
cord-346853-0c1qdjb5	155	27	et	et	FW
cord-346853-0c1qdjb5	155	28	al	al	NNP
cord-346853-0c1qdjb5	155	29	.	.	NNP
cord-346853-0c1qdjb5	155	30	2001	2001	CD
cord-346853-0c1qdjb5	155	31	)	)	-RRB-
cord-346853-0c1qdjb5	155	32	,	,	,
cord-346853-0c1qdjb5	155	33	it	-PRON-	PRP
cord-346853-0c1qdjb5	155	34	is	be	VBZ
cord-346853-0c1qdjb5	155	35	unclear	unclear	JJ
cord-346853-0c1qdjb5	155	36	whether	whether	IN
cord-346853-0c1qdjb5	155	37	this	this	DT
cord-346853-0c1qdjb5	155	38	reflects	reflect	VBZ
cord-346853-0c1qdjb5	155	39	adaptive	adaptive	JJ
cord-346853-0c1qdjb5	155	40	evolution	evolution	NN
cord-346853-0c1qdjb5	155	41	or	or	CC
cord-346853-0c1qdjb5	155	42	a	a	DT
cord-346853-0c1qdjb5	155	43	relaxation	relaxation	NN
cord-346853-0c1qdjb5	155	44	of	of	IN
cord-346853-0c1qdjb5	155	45	selective	selective	JJ
cord-346853-0c1qdjb5	155	46	constraints	constraint	NNS
cord-346853-0c1qdjb5	155	47	.	.	.
cord-346853-0c1qdjb5	156	1	Finally	finally	RB
cord-346853-0c1qdjb5	156	2	,	,	,
cord-346853-0c1qdjb5	156	3	viral	viral	JJ
cord-346853-0c1qdjb5	156	4	exposure	exposure	NN
cord-346853-0c1qdjb5	156	5	to	to	IN
cord-346853-0c1qdjb5	156	6	hosts	host	NNS
cord-346853-0c1qdjb5	156	7	of	of	IN
cord-346853-0c1qdjb5	156	8	the	the	DT
cord-346853-0c1qdjb5	156	9	right	right	JJ
cord-346853-0c1qdjb5	156	10	genetic	genetic	JJ
cord-346853-0c1qdjb5	156	11	configuration	configuration	NN
cord-346853-0c1qdjb5	156	12	may	may	MD
cord-346853-0c1qdjb5	156	13	also	also	RB
cord-346853-0c1qdjb5	156	14	be	be	VB
cord-346853-0c1qdjb5	156	15	of	of	IN
cord-346853-0c1qdjb5	156	16	critical	critical	JJ
cord-346853-0c1qdjb5	156	17	importance	importance	NN
cord-346853-0c1qdjb5	156	18	in	in	IN
cord-346853-0c1qdjb5	156	19	the	the	DT
cord-346853-0c1qdjb5	156	20	establishment	establishment	NN
cord-346853-0c1qdjb5	156	21	of	of	IN
cord-346853-0c1qdjb5	156	22	new	new	JJ
cord-346853-0c1qdjb5	156	23	infections	infection	NNS
cord-346853-0c1qdjb5	156	24	.	.	.
cord-346853-0c1qdjb5	157	1	For	for	IN
cord-346853-0c1qdjb5	157	2	example	example	NN
cord-346853-0c1qdjb5	157	3	,	,	,
cord-346853-0c1qdjb5	157	4	it	-PRON-	PRP
cord-346853-0c1qdjb5	157	5	might	may	MD
cord-346853-0c1qdjb5	157	6	be	be	VB
cord-346853-0c1qdjb5	157	7	that	that	IN
cord-346853-0c1qdjb5	157	8	a	a	DT
cord-346853-0c1qdjb5	157	9	particular	particular	JJ
cord-346853-0c1qdjb5	157	10	host	host	NN
cord-346853-0c1qdjb5	157	11	HLA	HLA	NNP
cord-346853-0c1qdjb5	157	12	type	type	NN
cord-346853-0c1qdjb5	157	13	is	be	VBZ
cord-346853-0c1qdjb5	157	14	a	a	DT
cord-346853-0c1qdjb5	157	15	more	more	RBR
cord-346853-0c1qdjb5	157	16	willing	willing	JJ
cord-346853-0c1qdjb5	157	17	recipient	recipient	NN
cord-346853-0c1qdjb5	157	18	of	of	IN
cord-346853-0c1qdjb5	157	19	an	an	DT
cord-346853-0c1qdjb5	157	20	emergent	emergent	JJ
cord-346853-0c1qdjb5	157	21	virus	virus	NN
cord-346853-0c1qdjb5	157	22	than	than	IN
cord-346853-0c1qdjb5	157	23	another	another	DT
cord-346853-0c1qdjb5	157	24	.	.	.
cord-346853-0c1qdjb5	158	1	In	in	IN
cord-346853-0c1qdjb5	158	2	these	these	DT
cord-346853-0c1qdjb5	158	3	circumstances	circumstance	NNS
cord-346853-0c1qdjb5	158	4	,	,	,
cord-346853-0c1qdjb5	158	5	it	-PRON-	PRP
cord-346853-0c1qdjb5	158	6	is	be	VBZ
cord-346853-0c1qdjb5	158	7	the	the	DT
cord-346853-0c1qdjb5	158	8	particular	particular	JJ
cord-346853-0c1qdjb5	158	9	combination	combination	NN
cord-346853-0c1qdjb5	158	10	of	of	IN
cord-346853-0c1qdjb5	158	11	viral	viral	JJ
cord-346853-0c1qdjb5	158	12	sequence	sequence	NN
cord-346853-0c1qdjb5	158	13	and	and	CC
cord-346853-0c1qdjb5	158	14	host	host	NN
cord-346853-0c1qdjb5	158	15	immune	immune	JJ
cord-346853-0c1qdjb5	158	16	system	system	NN
cord-346853-0c1qdjb5	158	17	that	that	WDT
cord-346853-0c1qdjb5	158	18	is	be	VBZ
cord-346853-0c1qdjb5	158	19	necessary	necessary	JJ
cord-346853-0c1qdjb5	158	20	to	to	TO
cord-346853-0c1qdjb5	158	21	start	start	VB
cord-346853-0c1qdjb5	158	22	a	a	DT
cord-346853-0c1qdjb5	158	23	successful	successful	JJ
cord-346853-0c1qdjb5	158	24	infection	infection	NN
cord-346853-0c1qdjb5	158	25	.	.	.
cord-346853-0c1qdjb5	159	1	The	the	DT
cord-346853-0c1qdjb5	159	2	case	case	NN
cord-346853-0c1qdjb5	159	3	of	of	IN
cord-346853-0c1qdjb5	159	4	influenza	influenza	NN
cord-346853-0c1qdjb5	159	5	A	a	DT
cord-346853-0c1qdjb5	159	6	virus	virus	NN
cord-346853-0c1qdjb5	159	7	again	again	RB
cord-346853-0c1qdjb5	159	8	provides	provide	VBZ
cord-346853-0c1qdjb5	159	9	a	a	DT
cord-346853-0c1qdjb5	159	10	highly	highly	RB
cord-346853-0c1qdjb5	159	11	illustrative	illustrative	JJ
cord-346853-0c1qdjb5	159	12	example	example	NN
cord-346853-0c1qdjb5	159	13	(	(	-LRB-
cord-346853-0c1qdjb5	159	14	see	see	VB
cord-346853-0c1qdjb5	159	15	the	the	DT
cord-346853-0c1qdjb5	159	16	chapter	chapter	NN
cord-346853-0c1qdjb5	159	17	by	by	IN
cord-346853-0c1qdjb5	159	18	Webby	Webby	NNP
cord-346853-0c1qdjb5	159	19	et	et	NNP
cord-346853-0c1qdjb5	159	20	al	al	NNP
cord-346853-0c1qdjb5	159	21	.	.	NNP
cord-346853-0c1qdjb5	159	22	,	,	,
cord-346853-0c1qdjb5	159	23	this	this	DT
cord-346853-0c1qdjb5	159	24	volume	volume	NN
cord-346853-0c1qdjb5	159	25	)	)	-RRB-
cord-346853-0c1qdjb5	159	26	.	.	.
cord-346853-0c1qdjb5	160	1	Central	central	JJ
cord-346853-0c1qdjb5	160	2	(	(	-LRB-
cord-346853-0c1qdjb5	160	3	although	although	IN
cord-346853-0c1qdjb5	160	4	not	not	RB
cord-346853-0c1qdjb5	160	5	sufficient	sufficient	JJ
cord-346853-0c1qdjb5	160	6	)	)	-RRB-
cord-346853-0c1qdjb5	160	7	to	to	IN
cord-346853-0c1qdjb5	160	8	whether	whether	IN
cord-346853-0c1qdjb5	160	9	this	this	DT
cord-346853-0c1qdjb5	160	10	virus	virus	NN
cord-346853-0c1qdjb5	160	11	is	be	VBZ
cord-346853-0c1qdjb5	160	12	able	able	JJ
cord-346853-0c1qdjb5	160	13	to	to	TO
cord-346853-0c1qdjb5	160	14	productively	productively	RB
cord-346853-0c1qdjb5	160	15	infect	infect	VB
cord-346853-0c1qdjb5	160	16	hosts	host	NNS
cord-346853-0c1qdjb5	160	17	are	be	VBP
cord-346853-0c1qdjb5	160	18	the	the	DT
cord-346853-0c1qdjb5	160	19	sialic	sialic	JJ
cord-346853-0c1qdjb5	160	20	acid	acid	NN
cord-346853-0c1qdjb5	160	21	cell	cell	NN
cord-346853-0c1qdjb5	160	22	receptors	receptor	NNS
cord-346853-0c1qdjb5	160	23	found	find	VBN
cord-346853-0c1qdjb5	160	24	on	on	IN
cord-346853-0c1qdjb5	160	25	cell	cell	NN
cord-346853-0c1qdjb5	160	26	-	-	HYPH
cord-346853-0c1qdjb5	160	27	surface	surface	NN
cord-346853-0c1qdjb5	160	28	oligosaccharides	oligosaccharide	NNS
cord-346853-0c1qdjb5	160	29	.	.	.
cord-346853-0c1qdjb5	161	1	All	all	DT
cord-346853-0c1qdjb5	161	2	avian	avian	JJ
cord-346853-0c1qdjb5	161	3	influenza	influenza	NN
cord-346853-0c1qdjb5	161	4	viruses	virus	NNS
cord-346853-0c1qdjb5	161	5	replicate	replicate	VBP
cord-346853-0c1qdjb5	161	6	in	in	IN
cord-346853-0c1qdjb5	161	7	the	the	DT
cord-346853-0c1qdjb5	161	8	gastrointestinal	gastrointestinal	JJ
cord-346853-0c1qdjb5	161	9	tract	tract	NN
cord-346853-0c1qdjb5	161	10	and	and	CC
cord-346853-0c1qdjb5	161	11	bind	bind	VB
cord-346853-0c1qdjb5	161	12	to	to	IN
cord-346853-0c1qdjb5	161	13	sialic	sialic	JJ
cord-346853-0c1qdjb5	161	14	acid	acid	NN
cord-346853-0c1qdjb5	161	15	in	in	IN
cord-346853-0c1qdjb5	161	16	a	a	DT
cord-346853-0c1qdjb5	161	17	α	α	NN
cord-346853-0c1qdjb5	161	18	2,3-linkage	2,3-linkage	CD
cord-346853-0c1qdjb5	161	19	to	to	IN
cord-346853-0c1qdjb5	161	20	galactose	galactose	NN
cord-346853-0c1qdjb5	161	21	.	.	.
cord-346853-0c1qdjb5	162	1	In	in	IN
cord-346853-0c1qdjb5	162	2	contrast	contrast	NN
cord-346853-0c1qdjb5	162	3	,	,	,
cord-346853-0c1qdjb5	162	4	human	human	JJ
cord-346853-0c1qdjb5	162	5	influenza	influenza	NN
cord-346853-0c1qdjb5	162	6	viruses	virus	NNS
cord-346853-0c1qdjb5	162	7	replicate	replicate	VBP
cord-346853-0c1qdjb5	162	8	in	in	IN
cord-346853-0c1qdjb5	162	9	the	the	DT
cord-346853-0c1qdjb5	162	10	respiratory	respiratory	JJ
cord-346853-0c1qdjb5	162	11	tract	tract	NN
cord-346853-0c1qdjb5	162	12	,	,	,
cord-346853-0c1qdjb5	162	13	producing	produce	VBG
cord-346853-0c1qdjb5	162	14	the	the	DT
cord-346853-0c1qdjb5	162	15	distinctive	distinctive	JJ
cord-346853-0c1qdjb5	162	16	disease	disease	NN
cord-346853-0c1qdjb5	162	17	symptoms	symptom	NNS
cord-346853-0c1qdjb5	162	18	,	,	,
cord-346853-0c1qdjb5	162	19	and	and	CC
cord-346853-0c1qdjb5	162	20	bind	bind	VB
cord-346853-0c1qdjb5	162	21	to	to	IN
cord-346853-0c1qdjb5	162	22	sialic	sialic	JJ
cord-346853-0c1qdjb5	162	23	acid	acid	NN
cord-346853-0c1qdjb5	162	24	in	in	IN
cord-346853-0c1qdjb5	162	25	a	a	DT
cord-346853-0c1qdjb5	162	26	α	α	NN
cord-346853-0c1qdjb5	162	27	2,6-linkage	2,6-linkage	CD
cord-346853-0c1qdjb5	162	28	.	.	.
cord-346853-0c1qdjb5	163	1	Hence	hence	RB
cord-346853-0c1qdjb5	163	2	,	,	,
cord-346853-0c1qdjb5	163	3	the	the	DT
cord-346853-0c1qdjb5	163	4	shift	shift	NN
cord-346853-0c1qdjb5	163	5	from	from	IN
cord-346853-0c1qdjb5	163	6	α	α	NN
cord-346853-0c1qdjb5	163	7	2,3-to	2,3-to	CD
cord-346853-0c1qdjb5	163	8	α	α	NN
cord-346853-0c1qdjb5	163	9	2,6-linkage	2,6-linkage	NN
cord-346853-0c1qdjb5	163	10	is	be	VBZ
cord-346853-0c1qdjb5	163	11	critical	critical	JJ
cord-346853-0c1qdjb5	163	12	in	in	IN
cord-346853-0c1qdjb5	163	13	enabling	enable	VBG
cord-346853-0c1qdjb5	163	14	the	the	DT
cord-346853-0c1qdjb5	163	15	switch	switch	NN
cord-346853-0c1qdjb5	163	16	from	from	IN
cord-346853-0c1qdjb5	163	17	birds	bird	NNS
cord-346853-0c1qdjb5	163	18	to	to	IN
cord-346853-0c1qdjb5	163	19	humans	human	NNS
cord-346853-0c1qdjb5	163	20	and	and	CC
cord-346853-0c1qdjb5	163	21	often	often	RB
cord-346853-0c1qdjb5	163	22	involves	involve	VBZ
cord-346853-0c1qdjb5	163	23	changes	change	NNS
cord-346853-0c1qdjb5	163	24	at	at	IN
cord-346853-0c1qdjb5	163	25	two	two	CD
cord-346853-0c1qdjb5	163	26	amino	amino	NN
cord-346853-0c1qdjb5	163	27	acid	acid	NN
cord-346853-0c1qdjb5	163	28	residues	residue	NNS
cord-346853-0c1qdjb5	163	29	,	,	,
cord-346853-0c1qdjb5	163	30	although	although	IN
cord-346853-0c1qdjb5	163	31	mutations	mutation	NNS
cord-346853-0c1qdjb5	163	32	in	in	IN
cord-346853-0c1qdjb5	163	33	other	other	JJ
cord-346853-0c1qdjb5	163	34	genes	gene	NNS
cord-346853-0c1qdjb5	163	35	also	also	RB
cord-346853-0c1qdjb5	163	36	play	play	VBP
cord-346853-0c1qdjb5	163	37	key	key	JJ
cord-346853-0c1qdjb5	163	38	roles	role	NNS
cord-346853-0c1qdjb5	163	39	(	(	-LRB-
cord-346853-0c1qdjb5	163	40	Matrosovich	Matrosovich	NNP
cord-346853-0c1qdjb5	163	41	et	et	NNP
cord-346853-0c1qdjb5	163	42	al	al	NNP
cord-346853-0c1qdjb5	163	43	.	.	.
cord-346853-0c1qdjb5	163	44	1997	1997	CD
cord-346853-0c1qdjb5	163	45	;	;	.
cord-346853-0c1qdjb5	164	1	Taubenberger	Taubenberger	NNP
cord-346853-0c1qdjb5	164	2	et	et	NNP
cord-346853-0c1qdjb5	164	3	al	al	NNP
cord-346853-0c1qdjb5	164	4	.	.	NNP
cord-346853-0c1qdjb5	164	5	2005	2005	CD
cord-346853-0c1qdjb5	164	6	)	)	-RRB-
cord-346853-0c1qdjb5	164	7	.	.	.
cord-346853-0c1qdjb5	165	1	The	the	DT
cord-346853-0c1qdjb5	165	2	key	key	JJ
cord-346853-0c1qdjb5	165	3	question	question	NN
cord-346853-0c1qdjb5	165	4	,	,	,
cord-346853-0c1qdjb5	165	5	therefore	therefore	RB
cord-346853-0c1qdjb5	165	6	,	,	,
cord-346853-0c1qdjb5	165	7	is	be	VBZ
cord-346853-0c1qdjb5	165	8	whether	whether	IN
cord-346853-0c1qdjb5	165	9	these	these	DT
cord-346853-0c1qdjb5	165	10	mutations	mutation	NNS
cord-346853-0c1qdjb5	165	11	appear	appear	VBP
cord-346853-0c1qdjb5	165	12	de	de	FW
cord-346853-0c1qdjb5	165	13	novo	novo	NNP
cord-346853-0c1qdjb5	165	14	in	in	IN
cord-346853-0c1qdjb5	165	15	humans	human	NNS
cord-346853-0c1qdjb5	165	16	,	,	,
cord-346853-0c1qdjb5	165	17	in	in	IN
cord-346853-0c1qdjb5	165	18	the	the	DT
cord-346853-0c1qdjb5	165	19	short	short	JJ
cord-346853-0c1qdjb5	165	20	transmission	transmission	NN
cord-346853-0c1qdjb5	165	21	networks	network	NNS
cord-346853-0c1qdjb5	165	22	of	of	IN
cord-346853-0c1qdjb5	165	23	people	people	NNS
cord-346853-0c1qdjb5	165	24	who	who	WP
cord-346853-0c1qdjb5	165	25	initially	initially	RB
cord-346853-0c1qdjb5	165	26	suffer	suffer	VBP
cord-346853-0c1qdjb5	165	27	avian	avian	JJ
cord-346853-0c1qdjb5	165	28	influenza	influenza	NN
cord-346853-0c1qdjb5	165	29	,	,	,
cord-346853-0c1qdjb5	165	30	or	or	CC
cord-346853-0c1qdjb5	165	31	whether	whether	IN
cord-346853-0c1qdjb5	165	32	they	-PRON-	PRP
cord-346853-0c1qdjb5	165	33	preexist	preexist	VBP
cord-346853-0c1qdjb5	165	34	in	in	IN
cord-346853-0c1qdjb5	165	35	the	the	DT
cord-346853-0c1qdjb5	165	36	avian	avian	JJ
cord-346853-0c1qdjb5	165	37	population	population	NN
cord-346853-0c1qdjb5	165	38	,	,	,
cord-346853-0c1qdjb5	165	39	and	and	CC
cord-346853-0c1qdjb5	165	40	if	if	IN
cord-346853-0c1qdjb5	165	41	the	the	DT
cord-346853-0c1qdjb5	165	42	appropriate	appropriate	JJ
cord-346853-0c1qdjb5	165	43	strain	strain	NN
cord-346853-0c1qdjb5	165	44	is	be	VBZ
cord-346853-0c1qdjb5	165	45	transmitted	transmit	VBN
cord-346853-0c1qdjb5	165	46	,	,	,
cord-346853-0c1qdjb5	165	47	then	then	RB
cord-346853-0c1qdjb5	165	48	will	will	MD
cord-346853-0c1qdjb5	165	49	emergence	emergence	NN
cord-346853-0c1qdjb5	165	50	follow	follow	VB
cord-346853-0c1qdjb5	165	51	?	?	.
cord-346853-0c1qdjb5	166	1	Again	again	RB
cord-346853-0c1qdjb5	166	2	,	,	,
cord-346853-0c1qdjb5	166	3	there	there	EX
cord-346853-0c1qdjb5	166	4	is	be	VBZ
cord-346853-0c1qdjb5	166	5	little	little	JJ
cord-346853-0c1qdjb5	166	6	data	datum	NNS
cord-346853-0c1qdjb5	166	7	to	to	TO
cord-346853-0c1qdjb5	166	8	determine	determine	VB
cord-346853-0c1qdjb5	166	9	the	the	DT
cord-346853-0c1qdjb5	166	10	relative	relative	JJ
cord-346853-0c1qdjb5	166	11	importance	importance	NN
cord-346853-0c1qdjb5	166	12	of	of	IN
cord-346853-0c1qdjb5	166	13	these	these	DT
cord-346853-0c1qdjb5	166	14	two	two	CD
cord-346853-0c1qdjb5	166	15	aspects	aspect	NNS
cord-346853-0c1qdjb5	166	16	of	of	IN
cord-346853-0c1qdjb5	166	17	cross	cross	JJ
cord-346853-0c1qdjb5	166	18	-	-	JJ
cord-346853-0c1qdjb5	166	19	species	species	JJ
cord-346853-0c1qdjb5	166	20	transmission	transmission	NN
cord-346853-0c1qdjb5	166	21	dynamics	dynamic	NNS
cord-346853-0c1qdjb5	166	22	,	,	,
cord-346853-0c1qdjb5	166	23	although	although	IN
cord-346853-0c1qdjb5	166	24	the	the	DT
cord-346853-0c1qdjb5	166	25	population	population	NN
cord-346853-0c1qdjb5	166	26	size	size	NN
cord-346853-0c1qdjb5	166	27	of	of	IN
cord-346853-0c1qdjb5	166	28	influenza	influenza	NN
cord-346853-0c1qdjb5	166	29	virus	virus	NN
cord-346853-0c1qdjb5	166	30	in	in	IN
cord-346853-0c1qdjb5	166	31	avian	avian	JJ
cord-346853-0c1qdjb5	166	32	species	specie	NNS
cord-346853-0c1qdjb5	166	33	must	must	MD
cord-346853-0c1qdjb5	166	34	be	be	VB
cord-346853-0c1qdjb5	166	35	orders	order	NNS
cord-346853-0c1qdjb5	166	36	of	of	IN
cord-346853-0c1qdjb5	166	37	magnitude	magnitude	NN
cord-346853-0c1qdjb5	166	38	greater	great	JJR
cord-346853-0c1qdjb5	166	39	than	than	IN
cord-346853-0c1qdjb5	166	40	that	that	DT
cord-346853-0c1qdjb5	166	41	in	in	IN
cord-346853-0c1qdjb5	166	42	the	the	DT
cord-346853-0c1qdjb5	166	43	handful	handful	NN
cord-346853-0c1qdjb5	166	44	of	of	IN
cord-346853-0c1qdjb5	166	45	human	human	JJ
cord-346853-0c1qdjb5	166	46	cases	case	NNS
cord-346853-0c1qdjb5	166	47	during	during	IN
cord-346853-0c1qdjb5	166	48	most	most	JJS
cord-346853-0c1qdjb5	166	49	outbreaks	outbreak	NNS
cord-346853-0c1qdjb5	166	50	.	.	.
cord-346853-0c1qdjb5	167	1	We	-PRON-	PRP
cord-346853-0c1qdjb5	167	2	suggest	suggest	VBP
cord-346853-0c1qdjb5	167	3	that	that	IN
cord-346853-0c1qdjb5	167	4	three	three	CD
cord-346853-0c1qdjb5	167	5	important	important	JJ
cord-346853-0c1qdjb5	167	6	advances	advance	NNS
cord-346853-0c1qdjb5	167	7	are	be	VBP
cord-346853-0c1qdjb5	167	8	required	require	VBN
cord-346853-0c1qdjb5	167	9	to	to	TO
cord-346853-0c1qdjb5	167	10	fully	fully	RB
cord-346853-0c1qdjb5	167	11	elucidate	elucidate	VB
cord-346853-0c1qdjb5	167	12	the	the	DT
cord-346853-0c1qdjb5	167	13	role	role	NN
cord-346853-0c1qdjb5	167	14	of	of	IN
cord-346853-0c1qdjb5	167	15	adaptive	adaptive	JJ
cord-346853-0c1qdjb5	167	16	evolution	evolution	NN
cord-346853-0c1qdjb5	167	17	in	in	IN
cord-346853-0c1qdjb5	167	18	viral	viral	JJ
cord-346853-0c1qdjb5	167	19	emergence	emergence	NN
cord-346853-0c1qdjb5	167	20	.	.	.
cord-346853-0c1qdjb5	168	1	First	first	RB
cord-346853-0c1qdjb5	168	2	,	,	,
cord-346853-0c1qdjb5	168	3	improvements	improvement	NNS
cord-346853-0c1qdjb5	168	4	are	be	VBP
cord-346853-0c1qdjb5	168	5	needed	need	VBN
cord-346853-0c1qdjb5	168	6	in	in	IN
cord-346853-0c1qdjb5	168	7	the	the	DT
cord-346853-0c1qdjb5	168	8	analytical	analytical	JJ
cord-346853-0c1qdjb5	168	9	methods	method	NNS
cord-346853-0c1qdjb5	168	10	available	available	JJ
cord-346853-0c1qdjb5	168	11	to	to	TO
cord-346853-0c1qdjb5	168	12	measure	measure	VB
cord-346853-0c1qdjb5	168	13	selection	selection	NN
cord-346853-0c1qdjb5	168	14	pressures	pressure	NNS
cord-346853-0c1qdjb5	168	15	acting	act	VBG
cord-346853-0c1qdjb5	168	16	on	on	IN
cord-346853-0c1qdjb5	168	17	genes	gene	NNS
cord-346853-0c1qdjb5	168	18	.	.	.
cord-346853-0c1qdjb5	169	1	The	the	DT
cord-346853-0c1qdjb5	169	2	methods	method	NNS
cord-346853-0c1qdjb5	169	3	most	most	RBS
cord-346853-0c1qdjb5	169	4	commonly	commonly	RB
cord-346853-0c1qdjb5	169	5	used	use	VBN
cord-346853-0c1qdjb5	169	6	at	at	IN
cord-346853-0c1qdjb5	169	7	present	present	JJ
cord-346853-0c1qdjb5	169	8	involve	involve	VBP
cord-346853-0c1qdjb5	169	9	comparisons	comparison	NNS
cord-346853-0c1qdjb5	169	10	of	of	IN
cord-346853-0c1qdjb5	169	11	the	the	DT
cord-346853-0c1qdjb5	169	12	numbers	number	NNS
cord-346853-0c1qdjb5	169	13	of	of	IN
cord-346853-0c1qdjb5	169	14	synonymous	synonymous	JJ
cord-346853-0c1qdjb5	169	15	(	(	-LRB-
cord-346853-0c1qdjb5	169	16	d	d	NNP
cord-346853-0c1qdjb5	169	17	S	S	NNP
cord-346853-0c1qdjb5	169	18	)	)	-RRB-
cord-346853-0c1qdjb5	169	19	and	and	CC
cord-346853-0c1qdjb5	169	20	nonsynonymous	nonsynonymous	NNP
cord-346853-0c1qdjb5	169	21	(	(	-LRB-
cord-346853-0c1qdjb5	169	22	d	d	NNP
cord-346853-0c1qdjb5	169	23	N	N	NNP
cord-346853-0c1qdjb5	169	24	)	)	-RRB-
cord-346853-0c1qdjb5	169	25	substitutions	substitution	NNS
cord-346853-0c1qdjb5	169	26	per	per	IN
cord-346853-0c1qdjb5	169	27	site	site	NN
cord-346853-0c1qdjb5	169	28	.	.	.
cord-346853-0c1qdjb5	170	1	Although	although	IN
cord-346853-0c1qdjb5	170	2	informative	informative	JJ
cord-346853-0c1qdjb5	170	3	,	,	,
cord-346853-0c1qdjb5	170	4	these	these	DT
cord-346853-0c1qdjb5	170	5	methods	method	NNS
cord-346853-0c1qdjb5	170	6	are	be	VBP
cord-346853-0c1qdjb5	170	7	highly	highly	RB
cord-346853-0c1qdjb5	170	8	conservative	conservative	JJ
cord-346853-0c1qdjb5	170	9	and	and	CC
cord-346853-0c1qdjb5	170	10	are	be	VBP
cord-346853-0c1qdjb5	170	11	greatly	greatly	RB
cord-346853-0c1qdjb5	170	12	limited	limited	JJ
cord-346853-0c1qdjb5	170	13	when	when	WRB
cord-346853-0c1qdjb5	170	14	detecting	detect	VBG
cord-346853-0c1qdjb5	170	15	positive	positive	JJ
cord-346853-0c1qdjb5	170	16	selection	selection	NN
cord-346853-0c1qdjb5	170	17	at	at	IN
cord-346853-0c1qdjb5	170	18	sporadic	sporadic	JJ
cord-346853-0c1qdjb5	170	19	amino	amino	NN
cord-346853-0c1qdjb5	170	20	acid	acid	NN
cord-346853-0c1qdjb5	170	21	sites	site	NNS
cord-346853-0c1qdjb5	170	22	along	along	IN
cord-346853-0c1qdjb5	170	23	a	a	DT
cord-346853-0c1qdjb5	170	24	single	single	JJ
cord-346853-0c1qdjb5	170	25	lineage	lineage	NN
cord-346853-0c1qdjb5	170	26	,	,	,
cord-346853-0c1qdjb5	170	27	which	which	WDT
cord-346853-0c1qdjb5	170	28	may	may	MD
cord-346853-0c1qdjb5	170	29	be	be	VB
cord-346853-0c1qdjb5	170	30	the	the	DT
cord-346853-0c1qdjb5	170	31	form	form	NN
cord-346853-0c1qdjb5	170	32	of	of	IN
cord-346853-0c1qdjb5	170	33	adaptive	adaptive	JJ
cord-346853-0c1qdjb5	170	34	evolution	evolution	NN
cord-346853-0c1qdjb5	170	35	most	most	RBS
cord-346853-0c1qdjb5	170	36	often	often	RB
cord-346853-0c1qdjb5	170	37	associated	associate	VBN
cord-346853-0c1qdjb5	170	38	with	with	IN
cord-346853-0c1qdjb5	170	39	viral	viral	JJ
cord-346853-0c1qdjb5	170	40	emergence	emergence	NN
cord-346853-0c1qdjb5	170	41	.	.	.
cord-346853-0c1qdjb5	171	1	Second	second	RB
cord-346853-0c1qdjb5	171	2	,	,	,
cord-346853-0c1qdjb5	171	3	despite	despite	IN
cord-346853-0c1qdjb5	171	4	ever	ever	RB
cord-346853-0c1qdjb5	171	5	-	-	HYPH
cord-346853-0c1qdjb5	171	6	expanding	expand	VBG
cord-346853-0c1qdjb5	171	7	sequence	sequence	NN
cord-346853-0c1qdjb5	171	8	databases	database	NNS
cord-346853-0c1qdjb5	171	9	,	,	,
cord-346853-0c1qdjb5	171	10	there	there	EX
cord-346853-0c1qdjb5	171	11	are	be	VBP
cord-346853-0c1qdjb5	171	12	surprisingly	surprisingly	RB
cord-346853-0c1qdjb5	171	13	few	few	JJ
cord-346853-0c1qdjb5	171	14	examples	example	NNS
cord-346853-0c1qdjb5	171	15	where	where	WRB
cord-346853-0c1qdjb5	171	16	viral	viral	JJ
cord-346853-0c1qdjb5	171	17	sequence	sequence	NN
cord-346853-0c1qdjb5	171	18	data	data	NN
cord-346853-0c1qdjb5	171	19	is	be	VBZ
cord-346853-0c1qdjb5	171	20	available	available	JJ
cord-346853-0c1qdjb5	171	21	from	from	IN
cord-346853-0c1qdjb5	171	22	both	both	DT
cord-346853-0c1qdjb5	171	23	donor	donor	NN
cord-346853-0c1qdjb5	171	24	and	and	CC
cord-346853-0c1qdjb5	171	25	recipient	recipient	NN
cord-346853-0c1qdjb5	171	26	species	specie	NNS
cord-346853-0c1qdjb5	171	27	.	.	.
cord-346853-0c1qdjb5	172	1	As	as	IN
cord-346853-0c1qdjb5	172	2	a	a	DT
cord-346853-0c1qdjb5	172	3	case	case	NN
cord-346853-0c1qdjb5	172	4	in	in	IN
cord-346853-0c1qdjb5	172	5	point	point	NN
cord-346853-0c1qdjb5	172	6	,	,	,
cord-346853-0c1qdjb5	172	7	although	although	IN
cord-346853-0c1qdjb5	172	8	dengue	dengue	NN
cord-346853-0c1qdjb5	172	9	is	be	VBZ
cord-346853-0c1qdjb5	172	10	one	one	CD
cord-346853-0c1qdjb5	172	11	of	of	IN
cord-346853-0c1qdjb5	172	12	the	the	DT
cord-346853-0c1qdjb5	172	13	most	most	RBS
cord-346853-0c1qdjb5	172	14	important	important	JJ
cord-346853-0c1qdjb5	172	15	emerging	emerge	VBG
cord-346853-0c1qdjb5	172	16	viruses	virus	NNS
cord-346853-0c1qdjb5	172	17	of	of	IN
cord-346853-0c1qdjb5	172	18	humans	human	NNS
cord-346853-0c1qdjb5	172	19	and	and	CC
cord-346853-0c1qdjb5	172	20	a	a	DT
cord-346853-0c1qdjb5	172	21	multitude	multitude	NN
cord-346853-0c1qdjb5	172	22	of	of	IN
cord-346853-0c1qdjb5	172	23	sequence	sequence	NN
cord-346853-0c1qdjb5	172	24	data	datum	NNS
cord-346853-0c1qdjb5	172	25	from	from	IN
cord-346853-0c1qdjb5	172	26	humans	human	NNS
cord-346853-0c1qdjb5	172	27	are	be	VBP
cord-346853-0c1qdjb5	172	28	readily	readily	RB
cord-346853-0c1qdjb5	172	29	available	available	JJ
cord-346853-0c1qdjb5	172	30	,	,	,
cord-346853-0c1qdjb5	172	31	only	only	RB
cord-346853-0c1qdjb5	172	32	a	a	DT
cord-346853-0c1qdjb5	172	33	handful	handful	NN
cord-346853-0c1qdjb5	172	34	of	of	IN
cord-346853-0c1qdjb5	172	35	samples	sample	NNS
cord-346853-0c1qdjb5	172	36	have	have	VBP
cord-346853-0c1qdjb5	172	37	been	be	VBN
cord-346853-0c1qdjb5	172	38	collected	collect	VBN
cord-346853-0c1qdjb5	172	39	from	from	IN
cord-346853-0c1qdjb5	172	40	the	the	DT
cord-346853-0c1qdjb5	172	41	most	most	RBS
cord-346853-0c1qdjb5	172	42	likely	likely	JJ
cord-346853-0c1qdjb5	172	43	donor	donor	NN
cord-346853-0c1qdjb5	172	44	species	specie	NNS
cord-346853-0c1qdjb5	172	45	,	,	,
cord-346853-0c1qdjb5	172	46	Old	Old	NNP
cord-346853-0c1qdjb5	172	47	World	World	NNP
cord-346853-0c1qdjb5	172	48	monkeys	monkey	NNS
cord-346853-0c1qdjb5	172	49	(	(	-LRB-
cord-346853-0c1qdjb5	172	50	Wang	Wang	NNP
cord-346853-0c1qdjb5	172	51	2000	2000	CD
cord-346853-0c1qdjb5	172	52	)	)	-RRB-
cord-346853-0c1qdjb5	172	53	.	.	.
cord-346853-0c1qdjb5	173	1	Third	third	JJ
cord-346853-0c1qdjb5	173	2	,	,	,
cord-346853-0c1qdjb5	173	3	models	model	NNS
cord-346853-0c1qdjb5	173	4	of	of	IN
cord-346853-0c1qdjb5	173	5	evolution	evolution	NN
cord-346853-0c1qdjb5	173	6	need	need	VBP
cord-346853-0c1qdjb5	173	7	to	to	TO
cord-346853-0c1qdjb5	173	8	be	be	VB
cord-346853-0c1qdjb5	173	9	developed	develop	VBN
cord-346853-0c1qdjb5	173	10	that	that	WDT
cord-346853-0c1qdjb5	173	11	take	take	VB
cord-346853-0c1qdjb5	173	12	into	into	IN
cord-346853-0c1qdjb5	173	13	account	account	NN
cord-346853-0c1qdjb5	173	14	not	not	RB
cord-346853-0c1qdjb5	173	15	only	only	RB
cord-346853-0c1qdjb5	173	16	the	the	DT
cord-346853-0c1qdjb5	173	17	varying	vary	VBG
cord-346853-0c1qdjb5	173	18	selective	selective	JJ
cord-346853-0c1qdjb5	173	19	environment	environment	NN
cord-346853-0c1qdjb5	173	20	in	in	IN
cord-346853-0c1qdjb5	173	21	which	which	WDT
cord-346853-0c1qdjb5	173	22	most	most	JJS
cord-346853-0c1qdjb5	173	23	viral	viral	JJ
cord-346853-0c1qdjb5	173	24	pathogens	pathogen	NNS
cord-346853-0c1qdjb5	173	25	exist	exist	VBP
cord-346853-0c1qdjb5	174	1	but	but	CC
cord-346853-0c1qdjb5	174	2	also	also	RB
cord-346853-0c1qdjb5	174	3	that	that	DT
cord-346853-0c1qdjb5	174	4	accurately	accurately	RB
cord-346853-0c1qdjb5	174	5	reflect	reflect	VBP
cord-346853-0c1qdjb5	174	6	the	the	DT
cord-346853-0c1qdjb5	174	7	often	often	RB
cord-346853-0c1qdjb5	174	8	complex	complex	JJ
cord-346853-0c1qdjb5	174	9	life	life	NN
cord-346853-0c1qdjb5	174	10	cycle	cycle	NN
cord-346853-0c1qdjb5	174	11	of	of	IN
cord-346853-0c1qdjb5	174	12	emerging	emerge	VBG
cord-346853-0c1qdjb5	174	13	viruses	virus	NNS
cord-346853-0c1qdjb5	174	14	.	.	.
cord-346853-0c1qdjb5	175	1	These	these	DT
cord-346853-0c1qdjb5	175	2	models	model	NNS
cord-346853-0c1qdjb5	175	3	will	will	MD
cord-346853-0c1qdjb5	175	4	probably	probably	RB
cord-346853-0c1qdjb5	175	5	not	not	RB
cord-346853-0c1qdjb5	175	6	be	be	VB
cord-346853-0c1qdjb5	175	7	tractable	tractable	JJ
cord-346853-0c1qdjb5	175	8	by	by	IN
cord-346853-0c1qdjb5	175	9	analytical	analytical	JJ
cord-346853-0c1qdjb5	175	10	techniques	technique	NNS
cord-346853-0c1qdjb5	175	11	and	and	CC
cord-346853-0c1qdjb5	175	12	this	this	DT
cord-346853-0c1qdjb5	175	13	will	will	MD
cord-346853-0c1qdjb5	175	14	mean	mean	VB
cord-346853-0c1qdjb5	175	15	that	that	IN
cord-346853-0c1qdjb5	175	16	computationally	computationally	RB
cord-346853-0c1qdjb5	175	17	intensive	intensive	JJ
cord-346853-0c1qdjb5	175	18	simulation	simulation	NN
cord-346853-0c1qdjb5	175	19	studies	study	NNS
cord-346853-0c1qdjb5	175	20	will	will	MD
cord-346853-0c1qdjb5	175	21	become	become	VB
cord-346853-0c1qdjb5	175	22	an	an	DT
cord-346853-0c1qdjb5	175	23	increasingly	increasingly	RB
cord-346853-0c1qdjb5	175	24	important	important	JJ
cord-346853-0c1qdjb5	175	25	component	component	NN
cord-346853-0c1qdjb5	175	26	of	of	IN
cord-346853-0c1qdjb5	175	27	research	research	NN
cord-346853-0c1qdjb5	175	28	into	into	IN
cord-346853-0c1qdjb5	175	29	the	the	DT
cord-346853-0c1qdjb5	175	30	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	175	31	genetics	genetic	NNS
cord-346853-0c1qdjb5	175	32	of	of	IN
cord-346853-0c1qdjb5	175	33	emerging	emerge	VBG
cord-346853-0c1qdjb5	175	34	disease	disease	NN
cord-346853-0c1qdjb5	175	35	.	.	.
cord-346853-0c1qdjb5	176	1	Although	although	IN
cord-346853-0c1qdjb5	176	2	the	the	DT
cord-346853-0c1qdjb5	176	3	engine	engine	NN
cord-346853-0c1qdjb5	176	4	of	of	IN
cord-346853-0c1qdjb5	176	5	RNA	RNA	NNP
cord-346853-0c1qdjb5	176	6	virus	virus	NN
cord-346853-0c1qdjb5	176	7	evolution	evolution	NN
cord-346853-0c1qdjb5	176	8	is	be	VBZ
cord-346853-0c1qdjb5	176	9	undoubtedly	undoubtedly	RB
cord-346853-0c1qdjb5	176	10	their	-PRON-	PRP$
cord-346853-0c1qdjb5	176	11	high	high	JJ
cord-346853-0c1qdjb5	176	12	mutation	mutation	NN
cord-346853-0c1qdjb5	176	13	rate	rate	NN
cord-346853-0c1qdjb5	176	14	,	,	,
cord-346853-0c1qdjb5	176	15	there	there	EX
cord-346853-0c1qdjb5	176	16	is	be	VBZ
cord-346853-0c1qdjb5	176	17	mounting	mount	VBG
cord-346853-0c1qdjb5	176	18	evidence	evidence	NN
cord-346853-0c1qdjb5	176	19	that	that	IN
cord-346853-0c1qdjb5	176	20	the	the	DT
cord-346853-0c1qdjb5	176	21	genetic	genetic	JJ
cord-346853-0c1qdjb5	176	22	variability	variability	NN
cord-346853-0c1qdjb5	176	23	observed	observe	VBN
cord-346853-0c1qdjb5	176	24	in	in	IN
cord-346853-0c1qdjb5	176	25	RNA	RNA	NNP
cord-346853-0c1qdjb5	176	26	virus	virus	NN
cord-346853-0c1qdjb5	176	27	populations	population	NNS
cord-346853-0c1qdjb5	176	28	can	can	MD
cord-346853-0c1qdjb5	176	29	be	be	VB
cord-346853-0c1qdjb5	176	30	shaped	shape	VBN
cord-346853-0c1qdjb5	176	31	,	,	,
cord-346853-0c1qdjb5	176	32	in	in	IN
cord-346853-0c1qdjb5	176	33	part	part	NN
cord-346853-0c1qdjb5	176	34	,	,	,
cord-346853-0c1qdjb5	176	35	by	by	IN
cord-346853-0c1qdjb5	176	36	recombination	recombination	NN
cord-346853-0c1qdjb5	176	37	.	.	.
cord-346853-0c1qdjb5	177	1	Further	further	RB
cord-346853-0c1qdjb5	177	2	,	,	,
cord-346853-0c1qdjb5	177	3	because	because	IN
cord-346853-0c1qdjb5	177	4	recombination	recombination	NN
cord-346853-0c1qdjb5	177	5	is	be	VBZ
cord-346853-0c1qdjb5	177	6	a	a	DT
cord-346853-0c1qdjb5	177	7	process	process	NN
cord-346853-0c1qdjb5	177	8	that	that	WDT
cord-346853-0c1qdjb5	177	9	potentially	potentially	RB
cord-346853-0c1qdjb5	177	10	increases	increase	VBZ
cord-346853-0c1qdjb5	177	11	fitness	fitness	NN
cord-346853-0c1qdjb5	177	12	by	by	IN
cord-346853-0c1qdjb5	177	13	creating	create	VBG
cord-346853-0c1qdjb5	177	14	advantageous	advantageous	JJ
cord-346853-0c1qdjb5	177	15	genotypes	genotype	NNS
cord-346853-0c1qdjb5	177	16	and	and	CC
cord-346853-0c1qdjb5	177	17	removing	remove	VBG
cord-346853-0c1qdjb5	177	18	deleterious	deleterious	JJ
cord-346853-0c1qdjb5	177	19	mutations	mutation	NNS
cord-346853-0c1qdjb5	177	20	,	,	,
cord-346853-0c1qdjb5	177	21	it	-PRON-	PRP
cord-346853-0c1qdjb5	177	22	might	may	MD
cord-346853-0c1qdjb5	177	23	also	also	RB
cord-346853-0c1qdjb5	177	24	be	be	VB
cord-346853-0c1qdjb5	177	25	supposed	suppose	VBN
cord-346853-0c1qdjb5	177	26	that	that	IN
cord-346853-0c1qdjb5	177	27	it	-PRON-	PRP
cord-346853-0c1qdjb5	177	28	can	can	MD
cord-346853-0c1qdjb5	177	29	assist	assist	VB
cord-346853-0c1qdjb5	177	30	the	the	DT
cord-346853-0c1qdjb5	177	31	process	process	NN
cord-346853-0c1qdjb5	177	32	of	of	IN
cord-346853-0c1qdjb5	177	33	emergence	emergence	NN
cord-346853-0c1qdjb5	177	34	.	.	.
cord-346853-0c1qdjb5	178	1	This	this	DT
cord-346853-0c1qdjb5	178	2	is	be	VBZ
cord-346853-0c1qdjb5	178	3	perhaps	perhaps	RB
cord-346853-0c1qdjb5	178	4	best	good	JJS
cord-346853-0c1qdjb5	178	5	shown	show	VBN
cord-346853-0c1qdjb5	178	6	in	in	IN
cord-346853-0c1qdjb5	178	7	the	the	DT
cord-346853-0c1qdjb5	178	8	case	case	NN
cord-346853-0c1qdjb5	178	9	of	of	IN
cord-346853-0c1qdjb5	178	10	the	the	DT
cord-346853-0c1qdjb5	178	11	primate	primate	JJ
cord-346853-0c1qdjb5	178	12	lentiviruses	lentiviruse	NNS
cord-346853-0c1qdjb5	178	13	,	,	,
cord-346853-0c1qdjb5	178	14	such	such	JJ
cord-346853-0c1qdjb5	178	15	as	as	IN
cord-346853-0c1qdjb5	178	16	HIV	HIV	NNP
cord-346853-0c1qdjb5	178	17	,	,	,
cord-346853-0c1qdjb5	178	18	which	which	WDT
cord-346853-0c1qdjb5	178	19	not	not	RB
cord-346853-0c1qdjb5	178	20	only	only	RB
cord-346853-0c1qdjb5	178	21	experience	experience	VBP
cord-346853-0c1qdjb5	178	22	extremely	extremely	RB
cord-346853-0c1qdjb5	178	23	high	high	JJ
cord-346853-0c1qdjb5	178	24	rates	rate	NNS
cord-346853-0c1qdjb5	178	25	of	of	IN
cord-346853-0c1qdjb5	178	26	recombination	recombination	NN
cord-346853-0c1qdjb5	178	27	,	,	,
cord-346853-0c1qdjb5	178	28	with	with	IN
cord-346853-0c1qdjb5	178	29	multiple	multiple	JJ
cord-346853-0c1qdjb5	178	30	template	template	NN
cord-346853-0c1qdjb5	178	31	-	-	HYPH
cord-346853-0c1qdjb5	178	32	switching	switch	VBG
cord-346853-0c1qdjb5	178	33	events	event	NNS
cord-346853-0c1qdjb5	178	34	occurring	occur	VBG
cord-346853-0c1qdjb5	178	35	during	during	IN
cord-346853-0c1qdjb5	178	36	each	each	DT
cord-346853-0c1qdjb5	178	37	replication	replication	NN
cord-346853-0c1qdjb5	178	38	cycle	cycle	NN
cord-346853-0c1qdjb5	178	39	(	(	-LRB-
cord-346853-0c1qdjb5	178	40	Jung	Jung	NNP
cord-346853-0c1qdjb5	178	41	et	et	NNP
cord-346853-0c1qdjb5	178	42	al	al	NNP
cord-346853-0c1qdjb5	178	43	.	.	.
cord-346853-0c1qdjb5	178	44	2002	2002	CD
cord-346853-0c1qdjb5	178	45	)	)	-RRB-
cord-346853-0c1qdjb5	178	46	,	,	,
cord-346853-0c1qdjb5	178	47	but	but	CC
cord-346853-0c1qdjb5	178	48	where	where	WRB
cord-346853-0c1qdjb5	178	49	recombinant	recombinant	JJ
cord-346853-0c1qdjb5	178	50	viruses	virus	NNS
cord-346853-0c1qdjb5	178	51	seem	seem	VBP
cord-346853-0c1qdjb5	178	52	to	to	TO
cord-346853-0c1qdjb5	178	53	be	be	VB
cord-346853-0c1qdjb5	178	54	associated	associate	VBN
cord-346853-0c1qdjb5	178	55	with	with	IN
cord-346853-0c1qdjb5	178	56	many	many	JJ
cord-346853-0c1qdjb5	178	57	cases	case	NNS
cord-346853-0c1qdjb5	178	58	of	of	IN
cord-346853-0c1qdjb5	178	59	cross	cross	JJ
cord-346853-0c1qdjb5	178	60	-	-	JJ
cord-346853-0c1qdjb5	178	61	species	species	JJ
cord-346853-0c1qdjb5	178	62	transmission	transmission	NN
cord-346853-0c1qdjb5	179	1	(	(	-LRB-
cord-346853-0c1qdjb5	179	2	Bailes	Bailes	NNP
cord-346853-0c1qdjb5	179	3	et	et	NNP
cord-346853-0c1qdjb5	179	4	al	al	NNP
cord-346853-0c1qdjb5	179	5	.	.	NNP
cord-346853-0c1qdjb5	179	6	2003	2003	CD
cord-346853-0c1qdjb5	179	7	)	)	-RRB-
cord-346853-0c1qdjb5	179	8	.	.	.
cord-346853-0c1qdjb5	180	1	Similarly	similarly	RB
cord-346853-0c1qdjb5	180	2	,	,	,
cord-346853-0c1qdjb5	180	3	the	the	DT
cord-346853-0c1qdjb5	180	4	cross	cross	NN
cord-346853-0c1qdjb5	180	5	-	-	JJ
cord-346853-0c1qdjb5	180	6	species	species	JJ
cord-346853-0c1qdjb5	180	7	transmission	transmission	NN
cord-346853-0c1qdjb5	180	8	of	of	IN
cord-346853-0c1qdjb5	180	9	influenza	influenza	NN
cord-346853-0c1qdjb5	180	10	A	a	DT
cord-346853-0c1qdjb5	180	11	virus	virus	NN
cord-346853-0c1qdjb5	180	12	from	from	IN
cord-346853-0c1qdjb5	180	13	birds	bird	NNS
cord-346853-0c1qdjb5	180	14	to	to	IN
cord-346853-0c1qdjb5	180	15	human	human	JJ
cord-346853-0c1qdjb5	180	16	is	be	VBZ
cord-346853-0c1qdjb5	180	17	often	often	RB
cord-346853-0c1qdjb5	180	18	associated	associate	VBN
cord-346853-0c1qdjb5	180	19	with	with	IN
cord-346853-0c1qdjb5	180	20	reassortment	reassortment	NN
cord-346853-0c1qdjb5	180	21	among	among	IN
cord-346853-0c1qdjb5	180	22	hemagglutinin	hemagglutinin	NN
cord-346853-0c1qdjb5	180	23	(	(	-LRB-
cord-346853-0c1qdjb5	180	24	HA	HA	NNP
cord-346853-0c1qdjb5	180	25	)	)	-RRB-
cord-346853-0c1qdjb5	180	26	and	and	CC
cord-346853-0c1qdjb5	180	27	neuraminidase	neuraminidase	NN
cord-346853-0c1qdjb5	180	28	(	(	-LRB-
cord-346853-0c1qdjb5	180	29	NA	NA	NNP
cord-346853-0c1qdjb5	180	30	)	)	-RRB-
cord-346853-0c1qdjb5	180	31	subtypes	subtype	NNS
cord-346853-0c1qdjb5	180	32	(	(	-LRB-
cord-346853-0c1qdjb5	180	33	Webby	Webby	NNP
cord-346853-0c1qdjb5	180	34	and	and	CC
cord-346853-0c1qdjb5	180	35	Webster	Webster	NNP
cord-346853-0c1qdjb5	180	36	2001	2001	CD
cord-346853-0c1qdjb5	180	37	;	;	:
cord-346853-0c1qdjb5	180	38	see	see	VB
cord-346853-0c1qdjb5	180	39	the	the	DT
cord-346853-0c1qdjb5	180	40	chapter	chapter	NN
cord-346853-0c1qdjb5	180	41	by	by	IN
cord-346853-0c1qdjb5	180	42	Webby	Webby	NNP
cord-346853-0c1qdjb5	180	43	et	et	NNP
cord-346853-0c1qdjb5	180	44	al	al	NNP
cord-346853-0c1qdjb5	180	45	.	.	.
cord-346853-0c1qdjb5	181	1	,	,	,
cord-346853-0c1qdjb5	181	2	this	this	DT
cord-346853-0c1qdjb5	181	3	volume	volume	NN
cord-346853-0c1qdjb5	181	4	)	)	-RRB-
cord-346853-0c1qdjb5	181	5	.	.	.
cord-346853-0c1qdjb5	182	1	A	a	DT
cord-346853-0c1qdjb5	182	2	more	more	RBR
cord-346853-0c1qdjb5	182	3	recent	recent	JJ
cord-346853-0c1qdjb5	182	4	case	case	NN
cord-346853-0c1qdjb5	182	5	in	in	IN
cord-346853-0c1qdjb5	182	6	point	point	NN
cord-346853-0c1qdjb5	182	7	concerns	concern	VBZ
cord-346853-0c1qdjb5	182	8	the	the	DT
cord-346853-0c1qdjb5	182	9	emergence	emergence	NN
cord-346853-0c1qdjb5	182	10	of	of	IN
cord-346853-0c1qdjb5	182	11	SARS	SARS	NNP
cord-346853-0c1qdjb5	182	12	-	-	HYPH
cord-346853-0c1qdjb5	182	13	CoV.	CoV.	NNP
cord-346853-0c1qdjb5	183	1	In	in	IN
cord-346853-0c1qdjb5	183	2	this	this	DT
cord-346853-0c1qdjb5	183	3	case	case	NN
cord-346853-0c1qdjb5	183	4	,	,	,
cord-346853-0c1qdjb5	183	5	it	-PRON-	PRP
cord-346853-0c1qdjb5	183	6	has	have	VBZ
cord-346853-0c1qdjb5	183	7	been	be	VBN
cord-346853-0c1qdjb5	183	8	argued	argue	VBN
cord-346853-0c1qdjb5	183	9	that	that	IN
cord-346853-0c1qdjb5	183	10	human	human	JJ
cord-346853-0c1qdjb5	183	11	SARS	SARS	NNP
cord-346853-0c1qdjb5	183	12	-	-	HYPH
cord-346853-0c1qdjb5	183	13	CoV	CoV	NNP
cord-346853-0c1qdjb5	183	14	is	be	VBZ
cord-346853-0c1qdjb5	183	15	a	a	DT
cord-346853-0c1qdjb5	183	16	recombinant	recombinant	NN
cord-346853-0c1qdjb5	183	17	of	of	IN
cord-346853-0c1qdjb5	183	18	avian	avian	JJ
cord-346853-0c1qdjb5	183	19	and	and	CC
cord-346853-0c1qdjb5	183	20	other	other	JJ
cord-346853-0c1qdjb5	183	21	mammalian	mammalian	JJ
cord-346853-0c1qdjb5	183	22	coronaviruses	coronaviruse	NNS
cord-346853-0c1qdjb5	183	23	(	(	-LRB-
cord-346853-0c1qdjb5	183	24	Stavrinides	Stavrinides	NNP
cord-346853-0c1qdjb5	183	25	and	and	CC
cord-346853-0c1qdjb5	183	26	Guttman	Guttman	NNP
cord-346853-0c1qdjb5	183	27	2004	2004	CD
cord-346853-0c1qdjb5	183	28	)	)	-RRB-
cord-346853-0c1qdjb5	183	29	,	,	,
cord-346853-0c1qdjb5	183	30	and	and	CC
cord-346853-0c1qdjb5	183	31	that	that	DT
cord-346853-0c1qdjb5	183	32	recombination	recombination	NN
cord-346853-0c1qdjb5	183	33	may	may	MD
cord-346853-0c1qdjb5	183	34	even	even	RB
cord-346853-0c1qdjb5	183	35	have	have	VB
cord-346853-0c1qdjb5	183	36	allowed	allow	VBN
cord-346853-0c1qdjb5	183	37	the	the	DT
cord-346853-0c1qdjb5	183	38	virus	virus	NN
cord-346853-0c1qdjb5	183	39	to	to	TO
cord-346853-0c1qdjb5	183	40	acquire	acquire	VB
cord-346853-0c1qdjb5	183	41	the	the	DT
cord-346853-0c1qdjb5	183	42	critical	critical	JJ
cord-346853-0c1qdjb5	183	43	suite	suite	NN
cord-346853-0c1qdjb5	183	44	of	of	IN
cord-346853-0c1qdjb5	183	45	amino	amino	NN
cord-346853-0c1qdjb5	183	46	acid	acid	NN
cord-346853-0c1qdjb5	183	47	changes	change	NNS
cord-346853-0c1qdjb5	183	48	required	require	VBN
cord-346853-0c1qdjb5	183	49	to	to	TO
cord-346853-0c1qdjb5	183	50	cause	cause	VB
cord-346853-0c1qdjb5	183	51	infection	infection	NN
cord-346853-0c1qdjb5	183	52	in	in	IN
cord-346853-0c1qdjb5	183	53	humans	human	NNS
cord-346853-0c1qdjb5	183	54	(	(	-LRB-
cord-346853-0c1qdjb5	183	55	Stanhope	Stanhope	NNP
cord-346853-0c1qdjb5	183	56	et	et	NNP
cord-346853-0c1qdjb5	183	57	al	al	NNP
cord-346853-0c1qdjb5	183	58	.	.	.
cord-346853-0c1qdjb5	183	59	2004	2004	CD
cord-346853-0c1qdjb5	183	60	)	)	-RRB-
cord-346853-0c1qdjb5	183	61	.	.	.
cord-346853-0c1qdjb5	184	1	However	however	RB
cord-346853-0c1qdjb5	184	2	,	,	,
cord-346853-0c1qdjb5	184	3	a	a	DT
cord-346853-0c1qdjb5	184	4	closer	close	JJR
cord-346853-0c1qdjb5	184	5	inspection	inspection	NN
cord-346853-0c1qdjb5	184	6	of	of	IN
cord-346853-0c1qdjb5	184	7	the	the	DT
cord-346853-0c1qdjb5	184	8	pertinent	pertinent	JJ
cord-346853-0c1qdjb5	184	9	sequence	sequence	NN
cord-346853-0c1qdjb5	184	10	data	data	NN
cord-346853-0c1qdjb5	184	11	casts	cast	VBZ
cord-346853-0c1qdjb5	184	12	serious	serious	JJ
cord-346853-0c1qdjb5	184	13	doubt	doubt	NN
cord-346853-0c1qdjb5	184	14	on	on	IN
cord-346853-0c1qdjb5	184	15	this	this	DT
cord-346853-0c1qdjb5	184	16	hypothesis	hypothesis	NN
cord-346853-0c1qdjb5	184	17	(	(	-LRB-
cord-346853-0c1qdjb5	184	18	see	see	VB
cord-346853-0c1qdjb5	184	19	the	the	DT
cord-346853-0c1qdjb5	184	20	chapter	chapter	NN
cord-346853-0c1qdjb5	184	21	by	by	IN
cord-346853-0c1qdjb5	184	22	Wang	Wang	NNP
cord-346853-0c1qdjb5	184	23	and	and	CC
cord-346853-0c1qdjb5	184	24	Eaton	Eaton	NNP
cord-346853-0c1qdjb5	184	25	,	,	,
cord-346853-0c1qdjb5	184	26	this	this	DT
cord-346853-0c1qdjb5	184	27	volume	volume	NN
cord-346853-0c1qdjb5	184	28	)	)	-RRB-
cord-346853-0c1qdjb5	184	29	.	.	.
cord-346853-0c1qdjb5	185	1	First	first	RB
cord-346853-0c1qdjb5	185	2	,	,	,
cord-346853-0c1qdjb5	185	3	the	the	DT
cord-346853-0c1qdjb5	185	4	evidence	evidence	NN
cord-346853-0c1qdjb5	185	5	for	for	IN
cord-346853-0c1qdjb5	185	6	recombination	recombination	NN
cord-346853-0c1qdjb5	185	7	in	in	IN
cord-346853-0c1qdjb5	185	8	SARS	SARS	NNP
cord-346853-0c1qdjb5	185	9	coronavirus	coronavirus	NN
cord-346853-0c1qdjb5	185	10	is	be	VBZ
cord-346853-0c1qdjb5	185	11	weak	weak	JJ
cord-346853-0c1qdjb5	185	12	at	at	IN
cord-346853-0c1qdjb5	185	13	best	good	JJS
cord-346853-0c1qdjb5	185	14	,	,	,
cord-346853-0c1qdjb5	185	15	and	and	CC
cord-346853-0c1qdjb5	185	16	it	-PRON-	PRP
cord-346853-0c1qdjb5	185	17	seems	seem	VBZ
cord-346853-0c1qdjb5	185	18	equally	equally	RB
cord-346853-0c1qdjb5	185	19	likely	likely	JJ
cord-346853-0c1qdjb5	185	20	that	that	IN
cord-346853-0c1qdjb5	185	21	the	the	DT
cord-346853-0c1qdjb5	185	22	phylogenetic	phylogenetic	JJ
cord-346853-0c1qdjb5	185	23	signal	signal	NN
cord-346853-0c1qdjb5	185	24	said	say	VBD
cord-346853-0c1qdjb5	185	25	to	to	TO
cord-346853-0c1qdjb5	185	26	support	support	VB
cord-346853-0c1qdjb5	185	27	recombination	recombination	NN
cord-346853-0c1qdjb5	185	28	results	result	NNS
cord-346853-0c1qdjb5	185	29	from	from	IN
cord-346853-0c1qdjb5	185	30	variation	variation	NN
cord-346853-0c1qdjb5	185	31	in	in	IN
cord-346853-0c1qdjb5	185	32	substitution	substitution	NN
cord-346853-0c1qdjb5	185	33	rate	rate	NN
cord-346853-0c1qdjb5	185	34	among	among	IN
cord-346853-0c1qdjb5	185	35	lineages	lineage	NNS
cord-346853-0c1qdjb5	185	36	,	,	,
cord-346853-0c1qdjb5	185	37	such	such	JJ
cord-346853-0c1qdjb5	185	38	that	that	IN
cord-346853-0c1qdjb5	185	39	different	different	JJ
cord-346853-0c1qdjb5	185	40	genes	gene	NNS
cord-346853-0c1qdjb5	185	41	produce	produce	VBP
cord-346853-0c1qdjb5	185	42	slightly	slightly	RB
cord-346853-0c1qdjb5	185	43	different	different	JJ
cord-346853-0c1qdjb5	185	44	trees	tree	NNS
cord-346853-0c1qdjb5	185	45	(	(	-LRB-
cord-346853-0c1qdjb5	185	46	Gibbs	Gibbs	NNP
cord-346853-0c1qdjb5	185	47	et	et	NNP
cord-346853-0c1qdjb5	185	48	al	al	NNP
cord-346853-0c1qdjb5	185	49	.	.	.
cord-346853-0c1qdjb5	185	50	2004	2004	CD
cord-346853-0c1qdjb5	185	51	;	;	:
cord-346853-0c1qdjb5	185	52	Holmes	Holmes	NNP
cord-346853-0c1qdjb5	185	53	and	and	CC
cord-346853-0c1qdjb5	185	54	Rambaut	Rambaut	NNP
cord-346853-0c1qdjb5	185	55	2004	2004	CD
cord-346853-0c1qdjb5	185	56	)	)	-RRB-
cord-346853-0c1qdjb5	185	57	.	.	.
cord-346853-0c1qdjb5	186	1	Second	second	RB
cord-346853-0c1qdjb5	186	2	,	,	,
cord-346853-0c1qdjb5	186	3	the	the	DT
cord-346853-0c1qdjb5	186	4	proposed	propose	VBN
cord-346853-0c1qdjb5	186	5	recombination	recombination	NN
cord-346853-0c1qdjb5	186	6	in	in	IN
cord-346853-0c1qdjb5	186	7	SARS	SARS	NNP
cord-346853-0c1qdjb5	186	8	-	-	HYPH
cord-346853-0c1qdjb5	186	9	CoV	CoV	NNP
cord-346853-0c1qdjb5	186	10	would	would	MD
cord-346853-0c1qdjb5	186	11	have	have	VB
cord-346853-0c1qdjb5	186	12	involved	involve	VBN
cord-346853-0c1qdjb5	186	13	such	such	JJ
cord-346853-0c1qdjb5	186	14	distantly	distantly	RB
cord-346853-0c1qdjb5	186	15	related	related	JJ
cord-346853-0c1qdjb5	186	16	virus	virus	NN
cord-346853-0c1qdjb5	186	17	strains	strain	VBZ
cord-346853-0c1qdjb5	186	18	that	that	IN
cord-346853-0c1qdjb5	186	19	it	-PRON-	PRP
cord-346853-0c1qdjb5	186	20	can	can	MD
cord-346853-0c1qdjb5	186	21	not	not	RB
cord-346853-0c1qdjb5	186	22	be	be	VB
cord-346853-0c1qdjb5	186	23	responsible	responsible	JJ
cord-346853-0c1qdjb5	186	24	for	for	IN
cord-346853-0c1qdjb5	186	25	the	the	DT
cord-346853-0c1qdjb5	186	26	very	very	RB
cord-346853-0c1qdjb5	186	27	recent	recent	JJ
cord-346853-0c1qdjb5	186	28	emergence	emergence	NN
cord-346853-0c1qdjb5	186	29	of	of	IN
cord-346853-0c1qdjb5	186	30	the	the	DT
cord-346853-0c1qdjb5	186	31	virus	virus	NN
cord-346853-0c1qdjb5	186	32	in	in	IN
cord-346853-0c1qdjb5	186	33	humans	human	NNS
cord-346853-0c1qdjb5	186	34	(	(	-LRB-
cord-346853-0c1qdjb5	186	35	Holmes	Holmes	NNP
cord-346853-0c1qdjb5	186	36	and	and	CC
cord-346853-0c1qdjb5	186	37	Rambaut	Rambaut	NNP
cord-346853-0c1qdjb5	186	38	2004	2004	CD
cord-346853-0c1qdjb5	186	39	)	)	-RRB-
cord-346853-0c1qdjb5	186	40	.	.	.
cord-346853-0c1qdjb5	187	1	Another	another	DT
cord-346853-0c1qdjb5	187	2	reason	reason	NN
cord-346853-0c1qdjb5	187	3	to	to	TO
cord-346853-0c1qdjb5	187	4	doubt	doubt	VB
cord-346853-0c1qdjb5	187	5	the	the	DT
cord-346853-0c1qdjb5	187	6	role	role	NN
cord-346853-0c1qdjb5	187	7	played	play	VBN
cord-346853-0c1qdjb5	187	8	by	by	IN
cord-346853-0c1qdjb5	187	9	recombination	recombination	NN
cord-346853-0c1qdjb5	187	10	in	in	IN
cord-346853-0c1qdjb5	187	11	emergence	emergence	NN
cord-346853-0c1qdjb5	187	12	in	in	IN
cord-346853-0c1qdjb5	187	13	general	general	JJ
cord-346853-0c1qdjb5	187	14	is	be	VBZ
cord-346853-0c1qdjb5	187	15	that	that	IN
cord-346853-0c1qdjb5	187	16	,	,	,
cord-346853-0c1qdjb5	187	17	other	other	JJ
cord-346853-0c1qdjb5	187	18	than	than	IN
cord-346853-0c1qdjb5	187	19	in	in	IN
cord-346853-0c1qdjb5	187	20	the	the	DT
cord-346853-0c1qdjb5	187	21	retroviruses	retrovirus	NNS
cord-346853-0c1qdjb5	187	22	,	,	,
cord-346853-0c1qdjb5	187	23	recombination	recombination	NN
cord-346853-0c1qdjb5	187	24	is	be	VBZ
cord-346853-0c1qdjb5	187	25	not	not	RB
cord-346853-0c1qdjb5	187	26	a	a	DT
cord-346853-0c1qdjb5	187	27	particularly	particularly	RB
cord-346853-0c1qdjb5	187	28	common	common	JJ
cord-346853-0c1qdjb5	187	29	process	process	NN
cord-346853-0c1qdjb5	187	30	in	in	IN
cord-346853-0c1qdjb5	187	31	RNA	RNA	NNP
cord-346853-0c1qdjb5	187	32	viruses	virus	NNS
cord-346853-0c1qdjb5	187	33	and	and	CC
cord-346853-0c1qdjb5	187	34	there	there	EX
cord-346853-0c1qdjb5	187	35	is	be	VBZ
cord-346853-0c1qdjb5	187	36	no	no	DT
cord-346853-0c1qdjb5	187	37	reason	reason	NN
cord-346853-0c1qdjb5	187	38	to	to	TO
cord-346853-0c1qdjb5	187	39	suppose	suppose	VB
cord-346853-0c1qdjb5	187	40	that	that	IN
cord-346853-0c1qdjb5	187	41	it	-PRON-	PRP
cord-346853-0c1qdjb5	187	42	is	be	VBZ
cord-346853-0c1qdjb5	187	43	any	any	DT
cord-346853-0c1qdjb5	187	44	more	more	JJR
cord-346853-0c1qdjb5	187	45	than	than	IN
cord-346853-0c1qdjb5	187	46	a	a	DT
cord-346853-0c1qdjb5	187	47	mechanistic	mechanistic	JJ
cord-346853-0c1qdjb5	187	48	by	by	IN
cord-346853-0c1qdjb5	187	49	-	-	HYPH
cord-346853-0c1qdjb5	187	50	product	product	NN
cord-346853-0c1qdjb5	187	51	.	.	.
cord-346853-0c1qdjb5	188	1	For	for	IN
cord-346853-0c1qdjb5	188	2	example	example	NN
cord-346853-0c1qdjb5	188	3	,	,	,
cord-346853-0c1qdjb5	188	4	recombination	recombination	NN
cord-346853-0c1qdjb5	188	5	appears	appear	VBZ
cord-346853-0c1qdjb5	188	6	to	to	TO
cord-346853-0c1qdjb5	188	7	be	be	VB
cord-346853-0c1qdjb5	188	8	extremely	extremely	RB
cord-346853-0c1qdjb5	188	9	rare	rare	JJ
cord-346853-0c1qdjb5	188	10	in	in	IN
cord-346853-0c1qdjb5	188	11	negative	negative	JJ
cord-346853-0c1qdjb5	188	12	-	-	HYPH
cord-346853-0c1qdjb5	188	13	sense	sense	NN
cord-346853-0c1qdjb5	188	14	RNA	RNA	NNP
cord-346853-0c1qdjb5	188	15	viruses	virus	NNS
cord-346853-0c1qdjb5	188	16	(	(	-LRB-
cord-346853-0c1qdjb5	188	17	Chare	Chare	NNP
cord-346853-0c1qdjb5	188	18	et	et	NNP
cord-346853-0c1qdjb5	188	19	al	al	NNP
cord-346853-0c1qdjb5	188	20	.	.	NNP
cord-346853-0c1qdjb5	188	21	2003	2003	CD
cord-346853-0c1qdjb5	188	22	)	)	-RRB-
cord-346853-0c1qdjb5	188	23	,	,	,
cord-346853-0c1qdjb5	188	24	most	most	RBS
cord-346853-0c1qdjb5	188	25	likely	likely	JJ
cord-346853-0c1qdjb5	188	26	because	because	IN
cord-346853-0c1qdjb5	188	27	their	-PRON-	PRP$
cord-346853-0c1qdjb5	188	28	RNA	RNA	NNP
cord-346853-0c1qdjb5	188	29	is	be	VBZ
cord-346853-0c1qdjb5	188	30	always	always	RB
cord-346853-0c1qdjb5	188	31	encapsidated	encapsidate	VBN
cord-346853-0c1qdjb5	188	32	,	,	,
cord-346853-0c1qdjb5	188	33	thereby	thereby	RB
cord-346853-0c1qdjb5	188	34	greatly	greatly	RB
cord-346853-0c1qdjb5	188	35	limiting	limit	VBG
cord-346853-0c1qdjb5	188	36	the	the	DT
cord-346853-0c1qdjb5	188	37	template	template	NN
cord-346853-0c1qdjb5	188	38	-	-	HYPH
cord-346853-0c1qdjb5	188	39	switching	switching	NN
cord-346853-0c1qdjb5	188	40	thought	thought	NN
cord-346853-0c1qdjb5	188	41	to	to	TO
cord-346853-0c1qdjb5	188	42	be	be	VB
cord-346853-0c1qdjb5	188	43	central	central	JJ
cord-346853-0c1qdjb5	188	44	to	to	IN
cord-346853-0c1qdjb5	188	45	RNA	rna	NN
cord-346853-0c1qdjb5	188	46	recombination	recombination	NN
cord-346853-0c1qdjb5	188	47	.	.	.
cord-346853-0c1qdjb5	189	1	As	as	IN
cord-346853-0c1qdjb5	189	2	a	a	DT
cord-346853-0c1qdjb5	189	3	number	number	NN
cord-346853-0c1qdjb5	189	4	of	of	IN
cord-346853-0c1qdjb5	189	5	emerging	emerge	VBG
cord-346853-0c1qdjb5	189	6	viruses	virus	NNS
cord-346853-0c1qdjb5	189	7	have	have	VBP
cord-346853-0c1qdjb5	189	8	negative	negative	JJ
cord-346853-0c1qdjb5	189	9	-	-	HYPH
cord-346853-0c1qdjb5	189	10	sense	sense	NN
cord-346853-0c1qdjb5	189	11	RNA	RNA	NNP
cord-346853-0c1qdjb5	189	12	genomes	genome	NNS
cord-346853-0c1qdjb5	189	13	,	,	,
cord-346853-0c1qdjb5	189	14	this	this	DT
cord-346853-0c1qdjb5	189	15	automatically	automatically	RB
cord-346853-0c1qdjb5	189	16	argues	argue	VBZ
cord-346853-0c1qdjb5	189	17	against	against	IN
cord-346853-0c1qdjb5	189	18	recombination	recombination	NN
cord-346853-0c1qdjb5	189	19	as	as	IN
cord-346853-0c1qdjb5	189	20	a	a	DT
cord-346853-0c1qdjb5	189	21	general	general	JJ
cord-346853-0c1qdjb5	189	22	process	process	NN
cord-346853-0c1qdjb5	189	23	in	in	IN
cord-346853-0c1qdjb5	189	24	viral	viral	JJ
cord-346853-0c1qdjb5	189	25	emergence	emergence	NN
cord-346853-0c1qdjb5	189	26	.	.	.
cord-346853-0c1qdjb5	190	1	Similarly	similarly	RB
cord-346853-0c1qdjb5	190	2	,	,	,
cord-346853-0c1qdjb5	190	3	although	although	IN
cord-346853-0c1qdjb5	190	4	recombination	recombination	NN
cord-346853-0c1qdjb5	190	5	is	be	VBZ
cord-346853-0c1qdjb5	190	6	more	more	RBR
cord-346853-0c1qdjb5	190	7	common	common	JJ
cord-346853-0c1qdjb5	190	8	in	in	IN
cord-346853-0c1qdjb5	190	9	positive	positive	JJ
cord-346853-0c1qdjb5	190	10	-	-	HYPH
cord-346853-0c1qdjb5	190	11	sense	sense	NN
cord-346853-0c1qdjb5	190	12	RNA	RNA	NNP
cord-346853-0c1qdjb5	190	13	viruses	virus	NNS
cord-346853-0c1qdjb5	190	14	,	,	,
cord-346853-0c1qdjb5	190	15	in	in	IN
cord-346853-0c1qdjb5	190	16	most	most	JJS
cord-346853-0c1qdjb5	190	17	cases	case	NNS
cord-346853-0c1qdjb5	190	18	it	-PRON-	PRP
cord-346853-0c1qdjb5	190	19	appears	appear	VBZ
cord-346853-0c1qdjb5	190	20	to	to	TO
cord-346853-0c1qdjb5	190	21	be	be	VB
cord-346853-0c1qdjb5	190	22	a	a	DT
cord-346853-0c1qdjb5	190	23	sporadic	sporadic	JJ
cord-346853-0c1qdjb5	190	24	event	event	NN
cord-346853-0c1qdjb5	190	25	that	that	WDT
cord-346853-0c1qdjb5	190	26	does	do	VBZ
cord-346853-0c1qdjb5	190	27	not	not	RB
cord-346853-0c1qdjb5	190	28	occur	occur	VB
cord-346853-0c1qdjb5	190	29	at	at	IN
cord-346853-0c1qdjb5	190	30	a	a	DT
cord-346853-0c1qdjb5	190	31	high	high	JJ
cord-346853-0c1qdjb5	190	32	enough	enough	JJ
cord-346853-0c1qdjb5	190	33	frequency	frequency	NN
cord-346853-0c1qdjb5	190	34	to	to	TO
cord-346853-0c1qdjb5	190	35	make	make	VB
cord-346853-0c1qdjb5	190	36	it	-PRON-	PRP
cord-346853-0c1qdjb5	190	37	a	a	DT
cord-346853-0c1qdjb5	190	38	key	key	JJ
cord-346853-0c1qdjb5	190	39	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	190	40	strategy	strategy	NN
cord-346853-0c1qdjb5	190	41	,	,	,
cord-346853-0c1qdjb5	190	42	although	although	IN
cord-346853-0c1qdjb5	190	43	,	,	,
cord-346853-0c1qdjb5	190	44	of	of	IN
cord-346853-0c1qdjb5	190	45	course	course	NN
cord-346853-0c1qdjb5	190	46	,	,	,
cord-346853-0c1qdjb5	190	47	rare	rare	JJ
cord-346853-0c1qdjb5	190	48	events	event	NNS
cord-346853-0c1qdjb5	190	49	like	like	IN
cord-346853-0c1qdjb5	190	50	recombination	recombination	NN
cord-346853-0c1qdjb5	190	51	may	may	MD
cord-346853-0c1qdjb5	190	52	sometimes	sometimes	RB
cord-346853-0c1qdjb5	190	53	be	be	VB
cord-346853-0c1qdjb5	190	54	critical	critical	JJ
cord-346853-0c1qdjb5	190	55	in	in	IN
cord-346853-0c1qdjb5	190	56	kick	kick	NN
cord-346853-0c1qdjb5	190	57	-	-	HYPH
cord-346853-0c1qdjb5	190	58	starting	start	VBG
cord-346853-0c1qdjb5	190	59	the	the	DT
cord-346853-0c1qdjb5	190	60	process	process	NN
cord-346853-0c1qdjb5	190	61	of	of	IN
cord-346853-0c1qdjb5	190	62	viral	viral	JJ
cord-346853-0c1qdjb5	190	63	emergence	emergence	NN
cord-346853-0c1qdjb5	190	64	.	.	.
cord-346853-0c1qdjb5	191	1	Most	Most	JJS
cord-346853-0c1qdjb5	191	2	of	of	IN
cord-346853-0c1qdjb5	191	3	the	the	DT
cord-346853-0c1qdjb5	191	4	available	available	JJ
cord-346853-0c1qdjb5	191	5	evidence	evidence	NN
cord-346853-0c1qdjb5	191	6	suggests	suggest	VBZ
cord-346853-0c1qdjb5	191	7	that	that	IN
cord-346853-0c1qdjb5	191	8	recombination	recombination	NN
cord-346853-0c1qdjb5	191	9	rates	rate	NNS
cord-346853-0c1qdjb5	191	10	in	in	IN
cord-346853-0c1qdjb5	191	11	RNA	RNA	NNP
cord-346853-0c1qdjb5	191	12	viruses	virus	NNS
cord-346853-0c1qdjb5	191	13	are	be	VBP
cord-346853-0c1qdjb5	191	14	controlled	control	VBN
cord-346853-0c1qdjb5	191	15	by	by	IN
cord-346853-0c1qdjb5	191	16	two	two	CD
cord-346853-0c1qdjb5	191	17	factors	factor	NNS
cord-346853-0c1qdjb5	191	18	;	;	:
cord-346853-0c1qdjb5	191	19	the	the	DT
cord-346853-0c1qdjb5	191	20	ability	ability	NN
cord-346853-0c1qdjb5	191	21	of	of	IN
cord-346853-0c1qdjb5	191	22	the	the	DT
cord-346853-0c1qdjb5	191	23	virus	virus	NN
cord-346853-0c1qdjb5	191	24	in	in	IN
cord-346853-0c1qdjb5	191	25	question	question	NN
cord-346853-0c1qdjb5	191	26	to	to	TO
cord-346853-0c1qdjb5	191	27	undergo	undergo	VB
cord-346853-0c1qdjb5	191	28	template	template	NN
cord-346853-0c1qdjb5	191	29	switching	switching	NN
cord-346853-0c1qdjb5	191	30	and	and	CC
cord-346853-0c1qdjb5	191	31	the	the	DT
cord-346853-0c1qdjb5	191	32	frequency	frequency	NN
cord-346853-0c1qdjb5	191	33	with	with	IN
cord-346853-0c1qdjb5	191	34	which	which	WDT
cord-346853-0c1qdjb5	191	35	multiple	multiple	JJ
cord-346853-0c1qdjb5	191	36	infections	infection	NNS
cord-346853-0c1qdjb5	191	37	occur	occur	VBP
cord-346853-0c1qdjb5	191	38	.	.	.
cord-346853-0c1qdjb5	192	1	It	-PRON-	PRP
cord-346853-0c1qdjb5	192	2	is	be	VBZ
cord-346853-0c1qdjb5	192	3	these	these	DT
cord-346853-0c1qdjb5	192	4	factors	factor	NNS
cord-346853-0c1qdjb5	192	5	that	that	WDT
cord-346853-0c1qdjb5	192	6	explain	explain	VBP
cord-346853-0c1qdjb5	192	7	why	why	WRB
cord-346853-0c1qdjb5	192	8	HIV	HIV	NNP
cord-346853-0c1qdjb5	192	9	has	have	VBZ
cord-346853-0c1qdjb5	192	10	such	such	PDT
cord-346853-0c1qdjb5	192	11	a	a	DT
cord-346853-0c1qdjb5	192	12	high	high	JJ
cord-346853-0c1qdjb5	192	13	rate	rate	NN
cord-346853-0c1qdjb5	192	14	of	of	IN
cord-346853-0c1qdjb5	192	15	recombination	recombination	NN
cord-346853-0c1qdjb5	192	16	;	;	:
cord-346853-0c1qdjb5	192	17	the	the	DT
cord-346853-0c1qdjb5	192	18	virus	virus	NN
cord-346853-0c1qdjb5	192	19	possesses	possess	VBZ
cord-346853-0c1qdjb5	192	20	two	two	CD
cord-346853-0c1qdjb5	192	21	copies	copy	NNS
cord-346853-0c1qdjb5	192	22	of	of	IN
cord-346853-0c1qdjb5	192	23	the	the	DT
cord-346853-0c1qdjb5	192	24	RNA	RNA	NNP
cord-346853-0c1qdjb5	192	25	genome	genome	NN
cord-346853-0c1qdjb5	192	26	,	,	,
cord-346853-0c1qdjb5	192	27	which	which	WDT
cord-346853-0c1qdjb5	192	28	means	mean	VBZ
cord-346853-0c1qdjb5	192	29	that	that	IN
cord-346853-0c1qdjb5	192	30	template	template	NN
cord-346853-0c1qdjb5	192	31	switching	switching	NN
cord-346853-0c1qdjb5	192	32	will	will	MD
cord-346853-0c1qdjb5	192	33	occur	occur	VB
cord-346853-0c1qdjb5	192	34	readily	readily	RB
cord-346853-0c1qdjb5	192	35	,	,	,
cord-346853-0c1qdjb5	192	36	and	and	CC
cord-346853-0c1qdjb5	192	37	the	the	DT
cord-346853-0c1qdjb5	192	38	ease	ease	NN
cord-346853-0c1qdjb5	192	39	at	at	IN
cord-346853-0c1qdjb5	192	40	which	which	WDT
cord-346853-0c1qdjb5	192	41	the	the	DT
cord-346853-0c1qdjb5	192	42	virus	virus	NN
cord-346853-0c1qdjb5	192	43	has	have	VBZ
cord-346853-0c1qdjb5	192	44	spread	spread	VBN
cord-346853-0c1qdjb5	192	45	worldwide	worldwide	RB
cord-346853-0c1qdjb5	192	46	means	mean	NNS
cord-346853-0c1qdjb5	192	47	that	that	IN
cord-346853-0c1qdjb5	192	48	multiple	multiple	JJ
cord-346853-0c1qdjb5	192	49	infections	infection	NNS
cord-346853-0c1qdjb5	192	50	are	be	VBP
cord-346853-0c1qdjb5	192	51	abundant	abundant	JJ
cord-346853-0c1qdjb5	192	52	.	.	.
cord-346853-0c1qdjb5	193	1	However	however	RB
cord-346853-0c1qdjb5	193	2	,	,	,
cord-346853-0c1qdjb5	193	3	HIV	HIV	NNP
cord-346853-0c1qdjb5	193	4	appears	appear	VBZ
cord-346853-0c1qdjb5	193	5	to	to	TO
cord-346853-0c1qdjb5	193	6	be	be	VB
cord-346853-0c1qdjb5	193	7	the	the	DT
cord-346853-0c1qdjb5	193	8	exception	exception	NN
cord-346853-0c1qdjb5	193	9	rather	rather	RB
cord-346853-0c1qdjb5	193	10	than	than	IN
cord-346853-0c1qdjb5	193	11	the	the	DT
cord-346853-0c1qdjb5	193	12	rule	rule	NN
cord-346853-0c1qdjb5	193	13	.	.	.
cord-346853-0c1qdjb5	194	1	For	for	IN
cord-346853-0c1qdjb5	194	2	example	example	NN
cord-346853-0c1qdjb5	194	3	,	,	,
cord-346853-0c1qdjb5	194	4	HTLV	HTLV	NNP
cord-346853-0c1qdjb5	194	5	is	be	VBZ
cord-346853-0c1qdjb5	194	6	a	a	DT
cord-346853-0c1qdjb5	194	7	retrovirus	retrovirus	NN
cord-346853-0c1qdjb5	194	8	like	like	IN
cord-346853-0c1qdjb5	194	9	HIV	HIV	NNP
cord-346853-0c1qdjb5	194	10	and	and	CC
cord-346853-0c1qdjb5	194	11	is	be	VBZ
cord-346853-0c1qdjb5	194	12	also	also	RB
cord-346853-0c1qdjb5	194	13	reported	report	VBN
cord-346853-0c1qdjb5	194	14	to	to	TO
cord-346853-0c1qdjb5	194	15	have	have	VB
cord-346853-0c1qdjb5	194	16	jumped	jump	VBN
cord-346853-0c1qdjb5	194	17	species	species	NN
cord-346853-0c1qdjb5	194	18	boundaries	boundary	NNS
cord-346853-0c1qdjb5	194	19	(	(	-LRB-
cord-346853-0c1qdjb5	194	20	between	between	IN
cord-346853-0c1qdjb5	194	21	humans	human	NNS
cord-346853-0c1qdjb5	194	22	and	and	CC
cord-346853-0c1qdjb5	194	23	other	other	JJ
cord-346853-0c1qdjb5	194	24	primates	primate	NNS
cord-346853-0c1qdjb5	194	25	)	)	-RRB-
cord-346853-0c1qdjb5	194	26	during	during	IN
cord-346853-0c1qdjb5	194	27	its	-PRON-	PRP$
cord-346853-0c1qdjb5	194	28	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	194	29	history	history	NN
cord-346853-0c1qdjb5	194	30	.	.	.
cord-346853-0c1qdjb5	195	1	However	however	RB
cord-346853-0c1qdjb5	195	2	,	,	,
cord-346853-0c1qdjb5	195	3	there	there	EX
cord-346853-0c1qdjb5	195	4	is	be	VBZ
cord-346853-0c1qdjb5	195	5	no	no	DT
cord-346853-0c1qdjb5	195	6	evidence	evidence	NN
cord-346853-0c1qdjb5	195	7	for	for	IN
cord-346853-0c1qdjb5	195	8	recombination	recombination	NN
cord-346853-0c1qdjb5	195	9	in	in	IN
cord-346853-0c1qdjb5	195	10	HTLV	HTLV	NNP
cord-346853-0c1qdjb5	195	11	.	.	.
cord-346853-0c1qdjb5	196	1	In	in	IN
cord-346853-0c1qdjb5	196	2	fact	fact	NN
cord-346853-0c1qdjb5	196	3	,	,	,
cord-346853-0c1qdjb5	196	4	even	even	RB
cord-346853-0c1qdjb5	196	5	in	in	IN
cord-346853-0c1qdjb5	196	6	the	the	DT
cord-346853-0c1qdjb5	196	7	case	case	NN
cord-346853-0c1qdjb5	196	8	of	of	IN
cord-346853-0c1qdjb5	196	9	HIV	HIV	NNP
cord-346853-0c1qdjb5	196	10	it	-PRON-	PRP
cord-346853-0c1qdjb5	196	11	is	be	VBZ
cord-346853-0c1qdjb5	196	12	not	not	RB
cord-346853-0c1qdjb5	196	13	certain	certain	JJ
cord-346853-0c1qdjb5	196	14	that	that	IN
cord-346853-0c1qdjb5	196	15	recombination	recombination	NN
cord-346853-0c1qdjb5	196	16	has	have	VBZ
cord-346853-0c1qdjb5	196	17	been	be	VBN
cord-346853-0c1qdjb5	196	18	critical	critical	JJ
cord-346853-0c1qdjb5	196	19	to	to	IN
cord-346853-0c1qdjb5	196	20	emergence	emergence	NN
cord-346853-0c1qdjb5	196	21	,	,	,
cord-346853-0c1qdjb5	196	22	despite	despite	IN
cord-346853-0c1qdjb5	196	23	its	-PRON-	PRP$
cord-346853-0c1qdjb5	196	24	frequency	frequency	NN
cord-346853-0c1qdjb5	196	25	.	.	.
cord-346853-0c1qdjb5	197	1	Overall	overall	RB
cord-346853-0c1qdjb5	197	2	,	,	,
cord-346853-0c1qdjb5	197	3	as	as	IN
cord-346853-0c1qdjb5	197	4	the	the	DT
cord-346853-0c1qdjb5	197	5	rate	rate	NN
cord-346853-0c1qdjb5	197	6	of	of	IN
cord-346853-0c1qdjb5	197	7	recombination	recombination	NN
cord-346853-0c1qdjb5	197	8	,	,	,
cord-346853-0c1qdjb5	197	9	per	per	IN
cord-346853-0c1qdjb5	197	10	base	base	NN
cord-346853-0c1qdjb5	197	11	,	,	,
cord-346853-0c1qdjb5	197	12	will	will	MD
cord-346853-0c1qdjb5	197	13	be	be	VB
cord-346853-0c1qdjb5	197	14	very	very	RB
cord-346853-0c1qdjb5	197	15	much	much	RB
cord-346853-0c1qdjb5	197	16	lower	low	JJR
cord-346853-0c1qdjb5	197	17	than	than	IN
cord-346853-0c1qdjb5	197	18	that	that	DT
cord-346853-0c1qdjb5	197	19	of	of	IN
cord-346853-0c1qdjb5	197	20	mutation	mutation	NN
cord-346853-0c1qdjb5	197	21	for	for	IN
cord-346853-0c1qdjb5	197	22	most	most	JJS
cord-346853-0c1qdjb5	197	23	RNA	RNA	NNP
cord-346853-0c1qdjb5	197	24	viruses	virus	NNS
cord-346853-0c1qdjb5	197	25	,	,	,
cord-346853-0c1qdjb5	197	26	it	-PRON-	PRP
cord-346853-0c1qdjb5	197	27	seems	seem	VBZ
cord-346853-0c1qdjb5	197	28	logical	logical	JJ
cord-346853-0c1qdjb5	197	29	to	to	TO
cord-346853-0c1qdjb5	197	30	conclude	conclude	VB
cord-346853-0c1qdjb5	197	31	that	that	IN
cord-346853-0c1qdjb5	197	32	recombination	recombination	NN
cord-346853-0c1qdjb5	197	33	is	be	VBZ
cord-346853-0c1qdjb5	197	34	not	not	RB
cord-346853-0c1qdjb5	197	35	a	a	DT
cord-346853-0c1qdjb5	197	36	key	key	JJ
cord-346853-0c1qdjb5	197	37	requirement	requirement	NN
cord-346853-0c1qdjb5	197	38	for	for	IN
cord-346853-0c1qdjb5	197	39	emergence	emergence	NN
cord-346853-0c1qdjb5	197	40	,	,	,
cord-346853-0c1qdjb5	197	41	but	but	CC
cord-346853-0c1qdjb5	197	42	rather	rather	RB
cord-346853-0c1qdjb5	197	43	a	a	DT
cord-346853-0c1qdjb5	197	44	happy	happy	JJ
cord-346853-0c1qdjb5	197	45	coincidence	coincidence	NN
cord-346853-0c1qdjb5	197	46	.	.	.
cord-346853-0c1qdjb5	198	1	Much	much	JJ
cord-346853-0c1qdjb5	198	2	of	of	IN
cord-346853-0c1qdjb5	198	3	this	this	DT
cord-346853-0c1qdjb5	198	4	chapter	chapter	NN
cord-346853-0c1qdjb5	198	5	has	have	VBZ
cord-346853-0c1qdjb5	198	6	explored	explore	VBN
cord-346853-0c1qdjb5	198	7	the	the	DT
cord-346853-0c1qdjb5	198	8	issue	issue	NN
cord-346853-0c1qdjb5	198	9	of	of	IN
cord-346853-0c1qdjb5	198	10	the	the	DT
cord-346853-0c1qdjb5	198	11	role	role	NN
cord-346853-0c1qdjb5	198	12	played	play	VBN
cord-346853-0c1qdjb5	198	13	by	by	IN
cord-346853-0c1qdjb5	198	14	viral	viral	JJ
cord-346853-0c1qdjb5	198	15	evolution	evolution	NN
cord-346853-0c1qdjb5	198	16	in	in	IN
cord-346853-0c1qdjb5	198	17	the	the	DT
cord-346853-0c1qdjb5	198	18	process	process	NN
cord-346853-0c1qdjb5	198	19	of	of	IN
cord-346853-0c1qdjb5	198	20	emergence	emergence	NN
cord-346853-0c1qdjb5	198	21	.	.	.
cord-346853-0c1qdjb5	199	1	The	the	DT
cord-346853-0c1qdjb5	199	2	result	result	NN
cord-346853-0c1qdjb5	199	3	,	,	,
cord-346853-0c1qdjb5	199	4	contrary	contrary	JJ
cord-346853-0c1qdjb5	199	5	to	to	IN
cord-346853-0c1qdjb5	199	6	many	many	JJ
cord-346853-0c1qdjb5	199	7	perceptions	perception	NNS
cord-346853-0c1qdjb5	199	8	of	of	IN
cord-346853-0c1qdjb5	199	9	the	the	DT
cord-346853-0c1qdjb5	199	10	inherent	inherent	JJ
cord-346853-0c1qdjb5	199	11	adaptability	adaptability	NN
cord-346853-0c1qdjb5	199	12	of	of	IN
cord-346853-0c1qdjb5	199	13	RNA	RNA	NNP
cord-346853-0c1qdjb5	199	14	viruses	virus	NNS
cord-346853-0c1qdjb5	199	15	,	,	,
cord-346853-0c1qdjb5	199	16	is	be	VBZ
cord-346853-0c1qdjb5	199	17	that	that	DT
cord-346853-0c1qdjb5	199	18	successful	successful	JJ
cord-346853-0c1qdjb5	199	19	emergence	emergence	NN
cord-346853-0c1qdjb5	199	20	,	,	,
cord-346853-0c1qdjb5	199	21	characterized	characterize	VBN
cord-346853-0c1qdjb5	199	22	by	by	IN
cord-346853-0c1qdjb5	199	23	sustained	sustained	JJ
cord-346853-0c1qdjb5	199	24	human	human	NN
cord-346853-0c1qdjb5	199	25	-	-	HYPH
cord-346853-0c1qdjb5	199	26	to	to	IN
cord-346853-0c1qdjb5	199	27	-	-	HYPH
cord-346853-0c1qdjb5	199	28	human	human	JJ
cord-346853-0c1qdjb5	199	29	transmission	transmission	NN
cord-346853-0c1qdjb5	199	30	may	may	MD
cord-346853-0c1qdjb5	199	31	be	be	VB
cord-346853-0c1qdjb5	199	32	a	a	DT
cord-346853-0c1qdjb5	199	33	far	far	RB
cord-346853-0c1qdjb5	199	34	more	more	RBR
cord-346853-0c1qdjb5	199	35	difficult	difficult	JJ
cord-346853-0c1qdjb5	199	36	process	process	NN
cord-346853-0c1qdjb5	199	37	than	than	IN
cord-346853-0c1qdjb5	199	38	might	may	MD
cord-346853-0c1qdjb5	199	39	be	be	VB
cord-346853-0c1qdjb5	199	40	expected	expect	VBN
cord-346853-0c1qdjb5	199	41	given	give	VBN
cord-346853-0c1qdjb5	199	42	the	the	DT
cord-346853-0c1qdjb5	199	43	remarkable	remarkable	JJ
cord-346853-0c1qdjb5	199	44	rates	rate	NNS
cord-346853-0c1qdjb5	199	45	at	at	IN
cord-346853-0c1qdjb5	199	46	which	which	WDT
cord-346853-0c1qdjb5	199	47	RNA	RNA	NNP
cord-346853-0c1qdjb5	199	48	viruses	virus	NNS
cord-346853-0c1qdjb5	199	49	mutate	mutate	VBP
cord-346853-0c1qdjb5	199	50	.	.	.
cord-346853-0c1qdjb5	200	1	Why	why	WRB
cord-346853-0c1qdjb5	200	2	might	may	MD
cord-346853-0c1qdjb5	200	3	this	this	DT
cord-346853-0c1qdjb5	200	4	be	be	VB
cord-346853-0c1qdjb5	200	5	so	so	RB
cord-346853-0c1qdjb5	200	6	?	?	.
cord-346853-0c1qdjb5	201	1	One	one	CD
cord-346853-0c1qdjb5	201	2	probable	probable	JJ
cord-346853-0c1qdjb5	201	3	answer	answer	NN
cord-346853-0c1qdjb5	201	4	lies	lie	VBZ
cord-346853-0c1qdjb5	201	5	in	in	IN
cord-346853-0c1qdjb5	201	6	the	the	DT
cord-346853-0c1qdjb5	201	7	theory	theory	NN
cord-346853-0c1qdjb5	201	8	that	that	IN
cord-346853-0c1qdjb5	201	9	the	the	DT
cord-346853-0c1qdjb5	201	10	genomes	genome	NNS
cord-346853-0c1qdjb5	201	11	of	of	IN
cord-346853-0c1qdjb5	201	12	RNA	RNA	NNP
cord-346853-0c1qdjb5	201	13	viruses	virus	NNS
cord-346853-0c1qdjb5	201	14	are	be	VBP
cord-346853-0c1qdjb5	201	15	so	so	RB
cord-346853-0c1qdjb5	201	16	small	small	JJ
cord-346853-0c1qdjb5	201	17	(	(	-LRB-
cord-346853-0c1qdjb5	201	18	usually	usually	RB
cord-346853-0c1qdjb5	201	19	less	less	JJR
cord-346853-0c1qdjb5	201	20	than	than	IN
cord-346853-0c1qdjb5	201	21	15	15	CD
cord-346853-0c1qdjb5	201	22	kb	kb	NNS
cord-346853-0c1qdjb5	201	23	in	in	IN
cord-346853-0c1qdjb5	201	24	length	length	NN
cord-346853-0c1qdjb5	201	25	)	)	-RRB-
cord-346853-0c1qdjb5	201	26	,	,	,
cord-346853-0c1qdjb5	201	27	and	and	CC
cord-346853-0c1qdjb5	201	28	so	so	RB
cord-346853-0c1qdjb5	201	29	multifunctional	multifunctional	JJ
cord-346853-0c1qdjb5	201	30	,	,	,
cord-346853-0c1qdjb5	201	31	that	that	IN
cord-346853-0c1qdjb5	201	32	most	most	JJS
cord-346853-0c1qdjb5	201	33	mutations	mutation	NNS
cord-346853-0c1qdjb5	201	34	are	be	VBP
cord-346853-0c1qdjb5	201	35	likely	likely	JJ
cord-346853-0c1qdjb5	201	36	to	to	TO
cord-346853-0c1qdjb5	201	37	affect	affect	VB
cord-346853-0c1qdjb5	201	38	some	some	DT
cord-346853-0c1qdjb5	201	39	critical	critical	JJ
cord-346853-0c1qdjb5	201	40	aspect	aspect	NN
cord-346853-0c1qdjb5	201	41	of	of	IN
cord-346853-0c1qdjb5	201	42	virus	virus	NN
cord-346853-0c1qdjb5	201	43	biology	biology	NN
cord-346853-0c1qdjb5	201	44	(	(	-LRB-
cord-346853-0c1qdjb5	201	45	Holmes	Holmes	NNP
cord-346853-0c1qdjb5	201	46	2003a	2003a	CD
cord-346853-0c1qdjb5	201	47	)	)	-RRB-
cord-346853-0c1qdjb5	201	48	.	.	.
cord-346853-0c1qdjb5	202	1	As	as	IN
cord-346853-0c1qdjb5	202	2	such	such	JJ
cord-346853-0c1qdjb5	202	3	,	,	,
cord-346853-0c1qdjb5	202	4	although	although	IN
cord-346853-0c1qdjb5	202	5	mutations	mutation	NNS
cord-346853-0c1qdjb5	202	6	are	be	VBP
cord-346853-0c1qdjb5	202	7	abundant	abundant	JJ
cord-346853-0c1qdjb5	202	8	in	in	IN
cord-346853-0c1qdjb5	202	9	RNA	RNA	NNP
cord-346853-0c1qdjb5	202	10	viruses	virus	NNS
cord-346853-0c1qdjb5	202	11	,	,	,
cord-346853-0c1qdjb5	202	12	the	the	DT
cord-346853-0c1qdjb5	202	13	vast	vast	JJ
cord-346853-0c1qdjb5	202	14	majority	majority	NN
cord-346853-0c1qdjb5	202	15	are	be	VBP
cord-346853-0c1qdjb5	202	16	deleterious	deleterious	JJ
cord-346853-0c1qdjb5	202	17	,	,	,
cord-346853-0c1qdjb5	202	18	or	or	CC
cord-346853-0c1qdjb5	202	19	slightly	slightly	RB
cord-346853-0c1qdjb5	202	20	deleterious	deleterious	JJ
cord-346853-0c1qdjb5	202	21	,	,	,
cord-346853-0c1qdjb5	202	22	and	and	CC
cord-346853-0c1qdjb5	202	23	will	will	MD
cord-346853-0c1qdjb5	202	24	reduce	reduce	VB
cord-346853-0c1qdjb5	202	25	viral	viral	JJ
cord-346853-0c1qdjb5	202	26	fitness	fitness	NN
cord-346853-0c1qdjb5	202	27	in	in	IN
cord-346853-0c1qdjb5	202	28	the	the	DT
cord-346853-0c1qdjb5	202	29	long	long	JJ
cord-346853-0c1qdjb5	202	30	term	term	NN
cord-346853-0c1qdjb5	202	31	.	.	.
cord-346853-0c1qdjb5	203	1	Much	much	JJ
cord-346853-0c1qdjb5	203	2	of	of	IN
cord-346853-0c1qdjb5	203	3	the	the	DT
cord-346853-0c1qdjb5	203	4	genetic	genetic	JJ
cord-346853-0c1qdjb5	203	5	variation	variation	NN
cord-346853-0c1qdjb5	203	6	sampled	sample	VBN
cord-346853-0c1qdjb5	203	7	within	within	IN
cord-346853-0c1qdjb5	203	8	RNA	RNA	NNP
cord-346853-0c1qdjb5	203	9	virus	virus	NN
cord-346853-0c1qdjb5	203	10	populations	population	NNS
cord-346853-0c1qdjb5	203	11	,	,	,
cord-346853-0c1qdjb5	203	12	including	include	VBG
cord-346853-0c1qdjb5	203	13	those	those	DT
cord-346853-0c1qdjb5	203	14	of	of	IN
cord-346853-0c1qdjb5	203	15	emerging	emerge	VBG
cord-346853-0c1qdjb5	203	16	viruses	virus	NNS
cord-346853-0c1qdjb5	203	17	in	in	IN
cord-346853-0c1qdjb5	203	18	new	new	JJ
cord-346853-0c1qdjb5	203	19	host	host	NN
cord-346853-0c1qdjb5	203	20	species	specie	NNS
cord-346853-0c1qdjb5	203	21	,	,	,
cord-346853-0c1qdjb5	203	22	will	will	MD
cord-346853-0c1qdjb5	203	23	therefore	therefore	RB
cord-346853-0c1qdjb5	203	24	consist	consist	VB
cord-346853-0c1qdjb5	203	25	of	of	IN
cord-346853-0c1qdjb5	203	26	short	short	RB
cord-346853-0c1qdjb5	203	27	-	-	HYPH
cord-346853-0c1qdjb5	203	28	lived	live	VBN
cord-346853-0c1qdjb5	203	29	deleterious	deleterious	JJ
cord-346853-0c1qdjb5	203	30	mutations	mutation	NNS
cord-346853-0c1qdjb5	203	31	,	,	,
cord-346853-0c1qdjb5	203	32	which	which	WDT
cord-346853-0c1qdjb5	203	33	can	can	MD
cord-346853-0c1qdjb5	203	34	be	be	VB
cord-346853-0c1qdjb5	203	35	thought	think	VBN
cord-346853-0c1qdjb5	203	36	of	of	IN
cord-346853-0c1qdjb5	203	37	as	as	IN
cord-346853-0c1qdjb5	203	38	a	a	DT
cord-346853-0c1qdjb5	203	39	form	form	NN
cord-346853-0c1qdjb5	203	40	of	of	IN
cord-346853-0c1qdjb5	203	41	mutational	mutational	JJ
cord-346853-0c1qdjb5	203	42	straightjacket	straightjacket	NN
cord-346853-0c1qdjb5	203	43	.	.	.
cord-346853-0c1qdjb5	204	1	Unlike	unlike	IN
cord-346853-0c1qdjb5	204	2	many	many	JJ
cord-346853-0c1qdjb5	204	3	other	other	JJ
cord-346853-0c1qdjb5	204	4	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	204	5	systems	system	NNS
cord-346853-0c1qdjb5	204	6	that	that	WDT
cord-346853-0c1qdjb5	204	7	are	be	VBP
cord-346853-0c1qdjb5	204	8	dominated	dominate	VBN
cord-346853-0c1qdjb5	204	9	by	by	IN
cord-346853-0c1qdjb5	204	10	a	a	DT
cord-346853-0c1qdjb5	204	11	drift	drift	NN
cord-346853-0c1qdjb5	204	12	-	-	HYPH
cord-346853-0c1qdjb5	204	13	selection	selection	NN
cord-346853-0c1qdjb5	204	14	balance	balance	NN
cord-346853-0c1qdjb5	204	15	,	,	,
cord-346853-0c1qdjb5	204	16	viral	viral	JJ
cord-346853-0c1qdjb5	204	17	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	204	18	genetics	genetic	NNS
cord-346853-0c1qdjb5	204	19	may	may	MD
cord-346853-0c1qdjb5	204	20	be	be	VB
cord-346853-0c1qdjb5	204	21	dominated	dominate	VBN
cord-346853-0c1qdjb5	204	22	by	by	IN
cord-346853-0c1qdjb5	204	23	a	a	DT
cord-346853-0c1qdjb5	204	24	mutation	mutation	NN
cord-346853-0c1qdjb5	204	25	-	-	HYPH
cord-346853-0c1qdjb5	204	26	selection	selection	NN
cord-346853-0c1qdjb5	204	27	balance	balance	NN
cord-346853-0c1qdjb5	204	28	(	(	-LRB-
cord-346853-0c1qdjb5	204	29	Domingo	Domingo	NNP
cord-346853-0c1qdjb5	204	30	and	and	CC
cord-346853-0c1qdjb5	204	31	Holland	Holland	NNP
cord-346853-0c1qdjb5	204	32	1997	1997	CD
cord-346853-0c1qdjb5	204	33	)	)	-RRB-
cord-346853-0c1qdjb5	204	34	.	.	.
cord-346853-0c1qdjb5	205	1	The	the	DT
cord-346853-0c1qdjb5	205	2	requirements	requirement	NNS
cord-346853-0c1qdjb5	205	3	of	of	IN
cord-346853-0c1qdjb5	205	4	a	a	DT
cord-346853-0c1qdjb5	205	5	compact	compact	JJ
cord-346853-0c1qdjb5	205	6	and	and	CC
cord-346853-0c1qdjb5	205	7	highly	highly	RB
cord-346853-0c1qdjb5	205	8	pleiotropic	pleiotropic	JJ
cord-346853-0c1qdjb5	205	9	genome	genome	NN
cord-346853-0c1qdjb5	205	10	,	,	,
cord-346853-0c1qdjb5	205	11	coupled	couple	VBN
cord-346853-0c1qdjb5	205	12	with	with	IN
cord-346853-0c1qdjb5	205	13	a	a	DT
cord-346853-0c1qdjb5	205	14	high	high	JJ
cord-346853-0c1qdjb5	205	15	error	error	NN
cord-346853-0c1qdjb5	205	16	rate	rate	NN
cord-346853-0c1qdjb5	205	17	,	,	,
cord-346853-0c1qdjb5	205	18	lead	lead	VBP
cord-346853-0c1qdjb5	205	19	to	to	IN
cord-346853-0c1qdjb5	205	20	a	a	DT
cord-346853-0c1qdjb5	205	21	high	high	JJ
cord-346853-0c1qdjb5	205	22	mutational	mutational	JJ
cord-346853-0c1qdjb5	205	23	load	load	NN
cord-346853-0c1qdjb5	205	24	(	(	-LRB-
cord-346853-0c1qdjb5	205	25	Elena	Elena	NNP
cord-346853-0c1qdjb5	205	26	and	and	CC
cord-346853-0c1qdjb5	205	27	Moya	Moya	NNP
cord-346853-0c1qdjb5	205	28	1999	1999	CD
cord-346853-0c1qdjb5	205	29	)	)	-RRB-
cord-346853-0c1qdjb5	205	30	that	that	WDT
cord-346853-0c1qdjb5	205	31	leaves	leave	VBZ
cord-346853-0c1qdjb5	205	32	little	little	JJ
cord-346853-0c1qdjb5	205	33	room	room	NN
cord-346853-0c1qdjb5	205	34	for	for	IN
cord-346853-0c1qdjb5	205	35	the	the	DT
cord-346853-0c1qdjb5	205	36	limitless	limitless	JJ
cord-346853-0c1qdjb5	205	37	adaptability	adaptability	NN
cord-346853-0c1qdjb5	205	38	some	some	DT
cord-346853-0c1qdjb5	205	39	have	have	VBP
cord-346853-0c1qdjb5	205	40	attributed	attribute	VBN
cord-346853-0c1qdjb5	205	41	to	to	IN
cord-346853-0c1qdjb5	205	42	RNA	RNA	NNP
cord-346853-0c1qdjb5	205	43	viruses	virus	NNS
cord-346853-0c1qdjb5	205	44	.	.	.
cord-346853-0c1qdjb5	206	1	Indeed	indeed	RB
cord-346853-0c1qdjb5	206	2	,	,	,
cord-346853-0c1qdjb5	206	3	mutation	mutation	NN
cord-346853-0c1qdjb5	206	4	rates	rate	NNS
cord-346853-0c1qdjb5	206	5	are	be	VBP
cord-346853-0c1qdjb5	206	6	so	so	RB
cord-346853-0c1qdjb5	206	7	high	high	JJ
cord-346853-0c1qdjb5	206	8	that	that	IN
cord-346853-0c1qdjb5	206	9	it	-PRON-	PRP
cord-346853-0c1qdjb5	206	10	is	be	VBZ
cord-346853-0c1qdjb5	206	11	possible	possible	JJ
cord-346853-0c1qdjb5	206	12	that	that	IN
cord-346853-0c1qdjb5	206	13	even	even	RB
cord-346853-0c1qdjb5	206	14	highly	highly	RB
cord-346853-0c1qdjb5	206	15	beneficial	beneficial	JJ
cord-346853-0c1qdjb5	206	16	mutations	mutation	NNS
cord-346853-0c1qdjb5	206	17	will	will	MD
cord-346853-0c1qdjb5	206	18	not	not	RB
cord-346853-0c1qdjb5	206	19	be	be	VB
cord-346853-0c1qdjb5	206	20	able	able	JJ
cord-346853-0c1qdjb5	206	21	to	to	TO
cord-346853-0c1qdjb5	206	22	spread	spread	VB
cord-346853-0c1qdjb5	206	23	through	through	IN
cord-346853-0c1qdjb5	206	24	a	a	DT
cord-346853-0c1qdjb5	206	25	viral	viral	JJ
cord-346853-0c1qdjb5	206	26	population	population	NN
cord-346853-0c1qdjb5	206	27	because	because	IN
cord-346853-0c1qdjb5	206	28	they	-PRON-	PRP
cord-346853-0c1qdjb5	206	29	are	be	VBP
cord-346853-0c1qdjb5	206	30	,	,	,
cord-346853-0c1qdjb5	206	31	by	by	IN
cord-346853-0c1qdjb5	206	32	chance	chance	NN
cord-346853-0c1qdjb5	206	33	,	,	,
cord-346853-0c1qdjb5	206	34	linked	link	VBN
cord-346853-0c1qdjb5	206	35	to	to	IN
cord-346853-0c1qdjb5	206	36	deleterious	deleterious	JJ
cord-346853-0c1qdjb5	206	37	mutations	mutation	NNS
cord-346853-0c1qdjb5	206	38	that	that	WDT
cord-346853-0c1qdjb5	206	39	arise	arise	VBP
cord-346853-0c1qdjb5	206	40	in	in	IN
cord-346853-0c1qdjb5	206	41	the	the	DT
cord-346853-0c1qdjb5	206	42	same	same	JJ
cord-346853-0c1qdjb5	206	43	genome	genome	NN
cord-346853-0c1qdjb5	206	44	.	.	.
cord-346853-0c1qdjb5	207	1	This	this	DT
cord-346853-0c1qdjb5	207	2	will	will	MD
cord-346853-0c1qdjb5	207	3	evidently	evidently	RB
cord-346853-0c1qdjb5	207	4	hinder	hinder	VB
cord-346853-0c1qdjb5	207	5	their	-PRON-	PRP$
cord-346853-0c1qdjb5	207	6	ability	ability	NN
cord-346853-0c1qdjb5	207	7	to	to	TO
cord-346853-0c1qdjb5	207	8	emerge	emerge	VB
cord-346853-0c1qdjb5	207	9	in	in	IN
cord-346853-0c1qdjb5	207	10	new	new	JJ
cord-346853-0c1qdjb5	207	11	hosts	host	NNS
cord-346853-0c1qdjb5	207	12	and	and	CC
cord-346853-0c1qdjb5	207	13	does	do	VBZ
cord-346853-0c1qdjb5	207	14	much	much	JJ
cord-346853-0c1qdjb5	207	15	to	to	TO
cord-346853-0c1qdjb5	207	16	explain	explain	VB
cord-346853-0c1qdjb5	207	17	why	why	WRB
cord-346853-0c1qdjb5	207	18	some	some	DT
cord-346853-0c1qdjb5	207	19	RNA	RNA	NNP
cord-346853-0c1qdjb5	207	20	viruses	virus	NNS
cord-346853-0c1qdjb5	207	21	are	be	VBP
cord-346853-0c1qdjb5	207	22	better	well	RBR
cord-346853-0c1qdjb5	207	23	able	able	JJ
cord-346853-0c1qdjb5	207	24	to	to	TO
cord-346853-0c1qdjb5	207	25	cross	cross	VB
cord-346853-0c1qdjb5	207	26	species	species	NN
cord-346853-0c1qdjb5	207	27	barriers	barrier	NNS
cord-346853-0c1qdjb5	207	28	than	than	IN
cord-346853-0c1qdjb5	207	29	others	other	NNS
cord-346853-0c1qdjb5	207	30	.	.	.
cord-346853-0c1qdjb5	208	1	As	as	IN
cord-346853-0c1qdjb5	208	2	such	such	JJ
cord-346853-0c1qdjb5	208	3	,	,	,
cord-346853-0c1qdjb5	208	4	we	-PRON-	PRP
cord-346853-0c1qdjb5	208	5	propose	propose	VBP
cord-346853-0c1qdjb5	208	6	that	that	IN
cord-346853-0c1qdjb5	208	7	the	the	DT
cord-346853-0c1qdjb5	208	8	true	true	JJ
cord-346853-0c1qdjb5	208	9	importance	importance	NN
cord-346853-0c1qdjb5	208	10	of	of	IN
cord-346853-0c1qdjb5	208	11	the	the	DT
cord-346853-0c1qdjb5	208	12	nearly	nearly	RB
cord-346853-0c1qdjb5	208	13	neutral	neutral	JJ
cord-346853-0c1qdjb5	208	14	(	(	-LRB-
cord-346853-0c1qdjb5	208	15	or	or	CC
cord-346853-0c1qdjb5	208	16	slightly	slightly	RB
cord-346853-0c1qdjb5	208	17	deleterious	deleterious	JJ
cord-346853-0c1qdjb5	208	18	)	)	-RRB-
cord-346853-0c1qdjb5	208	19	theory	theory	NN
cord-346853-0c1qdjb5	208	20	of	of	IN
cord-346853-0c1qdjb5	208	21	molecular	molecular	JJ
cord-346853-0c1qdjb5	208	22	evolution	evolution	NN
cord-346853-0c1qdjb5	208	23	(	(	-LRB-
cord-346853-0c1qdjb5	208	24	Ohta	Ohta	NNP
cord-346853-0c1qdjb5	208	25	1992	1992	CD
cord-346853-0c1qdjb5	208	26	(	(	-LRB-
cord-346853-0c1qdjb5	208	27	Ohta	Ohta	NNP
cord-346853-0c1qdjb5	208	28	,	,	,
cord-346853-0c1qdjb5	208	29	1998	1998	CD
cord-346853-0c1qdjb5	208	30	to	to	IN
cord-346853-0c1qdjb5	208	31	the	the	DT
cord-346853-0c1qdjb5	208	32	study	study	NN
cord-346853-0c1qdjb5	208	33	of	of	IN
cord-346853-0c1qdjb5	208	34	RNA	RNA	NNP
cord-346853-0c1qdjb5	208	35	viruses	virus	NNS
cord-346853-0c1qdjb5	208	36	has	have	VBZ
cord-346853-0c1qdjb5	208	37	not	not	RB
cord-346853-0c1qdjb5	208	38	been	be	VBN
cord-346853-0c1qdjb5	208	39	fully	fully	RB
cord-346853-0c1qdjb5	208	40	appreciated	appreciate	VBN
cord-346853-0c1qdjb5	208	41	,	,	,
cord-346853-0c1qdjb5	208	42	yet	yet	CC
cord-346853-0c1qdjb5	208	43	may	may	MD
cord-346853-0c1qdjb5	208	44	be	be	VB
cord-346853-0c1qdjb5	208	45	crucial	crucial	JJ
cord-346853-0c1qdjb5	208	46	to	to	TO
cord-346853-0c1qdjb5	208	47	fully	fully	RB
cord-346853-0c1qdjb5	208	48	understanding	understand	VBG
cord-346853-0c1qdjb5	208	49	emergence	emergence	NN
cord-346853-0c1qdjb5	208	50	.	.	.
cord-346853-0c1qdjb5	209	1	Evolution	evolution	NN
cord-346853-0c1qdjb5	209	2	of	of	IN
cord-346853-0c1qdjb5	209	3	cell	cell	NN
cord-346853-0c1qdjb5	209	4	recognition	recognition	NN
cord-346853-0c1qdjb5	209	5	by	by	IN
cord-346853-0c1qdjb5	209	6	viruses	virus	NNS
cord-346853-0c1qdjb5	209	7	Positively	positively	RB
cord-346853-0c1qdjb5	209	8	charged	charge	VBN
cord-346853-0c1qdjb5	209	9	amino	amino	NN
cord-346853-0c1qdjb5	209	10	acid	acid	NN
cord-346853-0c1qdjb5	209	11	substitutions	substitution	NNS
cord-346853-0c1qdjb5	209	12	in	in	IN
cord-346853-0c1qdjb5	209	13	the	the	DT
cord-346853-0c1qdjb5	209	14	E2	E2	NNP
cord-346853-0c1qdjb5	209	15	envelope	envelope	NN
cord-346853-0c1qdjb5	209	16	glycoprotein	glycoprotein	NN
cord-346853-0c1qdjb5	209	17	are	be	VBP
cord-346853-0c1qdjb5	209	18	associated	associate	VBN
cord-346853-0c1qdjb5	209	19	with	with	IN
cord-346853-0c1qdjb5	209	20	the	the	DT
cord-346853-0c1qdjb5	209	21	emergence	emergence	NN
cord-346853-0c1qdjb5	209	22	of	of	IN
cord-346853-0c1qdjb5	209	23	Venezuelan	venezuelan	JJ
cord-346853-0c1qdjb5	209	24	equine	equine	NN
cord-346853-0c1qdjb5	209	25	encephalitis	encephalitis	NN
cord-346853-0c1qdjb5	209	26	virus	virus	NN
cord-346853-0c1qdjb5	210	1	A	a	DT
cord-346853-0c1qdjb5	210	2	search	search	NN
cord-346853-0c1qdjb5	210	3	for	for	IN
cord-346853-0c1qdjb5	210	4	Ebola	Ebola	NNP
cord-346853-0c1qdjb5	210	5	virus	virus	NN
cord-346853-0c1qdjb5	210	6	in	in	IN
cord-346853-0c1qdjb5	210	7	animals	animal	NNS
cord-346853-0c1qdjb5	210	8	in	in	IN
cord-346853-0c1qdjb5	210	9	the	the	DT
cord-346853-0c1qdjb5	210	10	Democratic	Democratic	NNP
cord-346853-0c1qdjb5	210	11	Republic	Republic	NNP
cord-346853-0c1qdjb5	210	12	of	of	IN
cord-346853-0c1qdjb5	210	13	the	the	DT
cord-346853-0c1qdjb5	210	14	Congo	Congo	NNP
cord-346853-0c1qdjb5	210	15	and	and	CC
cord-346853-0c1qdjb5	210	16	Cameroon	Cameroon	NNP
cord-346853-0c1qdjb5	210	17	:	:	:
cord-346853-0c1qdjb5	211	1	ecologic	ecologic	JJ
cord-346853-0c1qdjb5	211	2	,	,	,
cord-346853-0c1qdjb5	211	3	virologic	virologic	NNP
cord-346853-0c1qdjb5	211	4	,	,	,
cord-346853-0c1qdjb5	211	5	and	and	CC
cord-346853-0c1qdjb5	211	6	serologic	serologic	NN
cord-346853-0c1qdjb5	211	7	surveys	survey	NNS
cord-346853-0c1qdjb5	211	8	,	,	,
cord-346853-0c1qdjb5	211	9	1979	1979	CD
cord-346853-0c1qdjb5	211	10	-	-	SYM
cord-346853-0c1qdjb5	211	11	1980	1980	CD
cord-346853-0c1qdjb5	211	12	Selection	Selection	NNP
cord-346853-0c1qdjb5	211	13	pressures	pressure	NNS
cord-346853-0c1qdjb5	211	14	in	in	IN
cord-346853-0c1qdjb5	211	15	the	the	DT
cord-346853-0c1qdjb5	211	16	capsid	capsid	JJ
cord-346853-0c1qdjb5	211	17	genes	gene	NNS
cord-346853-0c1qdjb5	211	18	of	of	IN
cord-346853-0c1qdjb5	211	19	plant	plant	NN
cord-346853-0c1qdjb5	211	20	RNA	RNA	NNP
cord-346853-0c1qdjb5	211	21	viruses	virus	NNS
cord-346853-0c1qdjb5	211	22	reflect	reflect	VBP
cord-346853-0c1qdjb5	211	23	mode	mode	NN
cord-346853-0c1qdjb5	211	24	of	of	IN
cord-346853-0c1qdjb5	211	25	transmission	transmission	NN
cord-346853-0c1qdjb5	211	26	Phylogenetic	Phylogenetic	NNP
cord-346853-0c1qdjb5	211	27	analysis	analysis	NN
cord-346853-0c1qdjb5	211	28	reveals	reveal	VBZ
cord-346853-0c1qdjb5	211	29	a	a	DT
cord-346853-0c1qdjb5	211	30	low	low	JJ
cord-346853-0c1qdjb5	211	31	rate	rate	NN
cord-346853-0c1qdjb5	211	32	of	of	IN
cord-346853-0c1qdjb5	211	33	homologous	homologous	JJ
cord-346853-0c1qdjb5	211	34	recombination	recombination	NN
cord-346853-0c1qdjb5	211	35	in	in	IN
cord-346853-0c1qdjb5	211	36	negative	negative	JJ
cord-346853-0c1qdjb5	211	37	-	-	HYPH
cord-346853-0c1qdjb5	211	38	sense	sense	NN
cord-346853-0c1qdjb5	211	39	RNA	RNA	NNP
cord-346853-0c1qdjb5	211	40	viruses	virus	NNS
cord-346853-0c1qdjb5	211	41	Diseases	disease	NNS
cord-346853-0c1qdjb5	211	42	of	of	IN
cord-346853-0c1qdjb5	211	43	humans	human	NNS
cord-346853-0c1qdjb5	211	44	and	and	CC
cord-346853-0c1qdjb5	211	45	their	-PRON-	PRP$
cord-346853-0c1qdjb5	211	46	domestic	domestic	JJ
cord-346853-0c1qdjb5	211	47	mammals	mammal	NNS
cord-346853-0c1qdjb5	211	48	:	:	:
cord-346853-0c1qdjb5	211	49	pathogen	pathogen	NN
cord-346853-0c1qdjb5	211	50	characteristics	characteristic	NNS
cord-346853-0c1qdjb5	211	51	,	,	,
cord-346853-0c1qdjb5	211	52	host	host	NN
cord-346853-0c1qdjb5	211	53	range	range	NN
cord-346853-0c1qdjb5	211	54	and	and	CC
cord-346853-0c1qdjb5	211	55	the	the	DT
cord-346853-0c1qdjb5	211	56	risk	risk	NN
cord-346853-0c1qdjb5	211	57	of	of	IN
cord-346853-0c1qdjb5	211	58	emergence	emergence	NN
cord-346853-0c1qdjb5	211	59	An	an	DT
cord-346853-0c1qdjb5	211	60	introduction	introduction	NN
cord-346853-0c1qdjb5	211	61	to	to	IN
cord-346853-0c1qdjb5	211	62	the	the	DT
cord-346853-0c1qdjb5	211	63	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	211	64	ecology	ecology	NN
cord-346853-0c1qdjb5	211	65	of	of	IN
cord-346853-0c1qdjb5	211	66	viruses	virus	NNS
cord-346853-0c1qdjb5	211	67	RNA	RNA	NNP
cord-346853-0c1qdjb5	211	68	virus	virus	NN
cord-346853-0c1qdjb5	211	69	mutations	mutation	NNS
cord-346853-0c1qdjb5	211	70	for	for	IN
cord-346853-0c1qdjb5	211	71	fitness	fitness	NN
cord-346853-0c1qdjb5	211	72	and	and	CC
cord-346853-0c1qdjb5	211	73	survival	survival	NN
cord-346853-0c1qdjb5	211	74	Rate	rate	NN
cord-346853-0c1qdjb5	211	75	of	of	IN
cord-346853-0c1qdjb5	211	76	deleterious	deleterious	JJ
cord-346853-0c1qdjb5	211	77	mutation	mutation	NN
cord-346853-0c1qdjb5	211	78	and	and	CC
cord-346853-0c1qdjb5	211	79	the	the	DT
cord-346853-0c1qdjb5	211	80	distribution	distribution	NN
cord-346853-0c1qdjb5	211	81	of	of	IN
cord-346853-0c1qdjb5	211	82	its	-PRON-	PRP$
cord-346853-0c1qdjb5	211	83	effects	effect	NNS
cord-346853-0c1qdjb5	211	84	on	on	IN
cord-346853-0c1qdjb5	211	85	fitness	fitness	NN
cord-346853-0c1qdjb5	211	86	in	in	IN
cord-346853-0c1qdjb5	211	87	vesicular	vesicular	JJ
cord-346853-0c1qdjb5	211	88	stomatitis	stomatitis	NN
cord-346853-0c1qdjb5	211	89	virus	virus	NN
cord-346853-0c1qdjb5	211	90	Human	human	JJ
cord-346853-0c1qdjb5	211	91	diseases	disease	NNS
cord-346853-0c1qdjb5	211	92	threaten	threaten	VBP
cord-346853-0c1qdjb5	211	93	great	great	JJ
cord-346853-0c1qdjb5	211	94	apes	ape	NNS
cord-346853-0c1qdjb5	212	1	MHC	MHC	NNP
cord-346853-0c1qdjb5	212	2	polymorphism	polymorphism	NN
cord-346853-0c1qdjb5	213	1	pre	pre	JJ
cord-346853-0c1qdjb5	213	2	-	-	JJ
cord-346853-0c1qdjb5	213	3	dating	dating	JJ
cord-346853-0c1qdjb5	213	4	speciation	speciation	NN
cord-346853-0c1qdjb5	214	1	Phylogenetic	phylogenetic	JJ
cord-346853-0c1qdjb5	214	2	relationships	relationship	NNS
cord-346853-0c1qdjb5	214	3	of	of	IN
cord-346853-0c1qdjb5	214	4	flaviviruses	flavivirus	NNS
cord-346853-0c1qdjb5	214	5	correlate	correlate	VBP
cord-346853-0c1qdjb5	214	6	with	with	IN
cord-346853-0c1qdjb5	214	7	their	-PRON-	PRP$
cord-346853-0c1qdjb5	214	8	epidemiology	epidemiology	NN
cord-346853-0c1qdjb5	214	9	,	,	,
cord-346853-0c1qdjb5	214	10	disease	disease	NNP
cord-346853-0c1qdjb5	214	11	association	association	NNP
cord-346853-0c1qdjb5	214	12	and	and	CC
cord-346853-0c1qdjb5	214	13	biogeography	biogeography	NNP
cord-346853-0c1qdjb5	215	1	The	the	DT
cord-346853-0c1qdjb5	215	2	phylogeny	phylogeny	NN
cord-346853-0c1qdjb5	215	3	of	of	IN
cord-346853-0c1qdjb5	215	4	SARS	SARS	NNP
cord-346853-0c1qdjb5	215	5	coronavirus	coronavirus	NN
cord-346853-0c1qdjb5	215	6	Population	Population	NNP
cord-346853-0c1qdjb5	215	7	genetics	genetic	NNS
cord-346853-0c1qdjb5	215	8	:	:	:
cord-346853-0c1qdjb5	215	9	a	a	DT
cord-346853-0c1qdjb5	215	10	concise	concise	JJ
cord-346853-0c1qdjb5	215	11	course	course	NN
cord-346853-0c1qdjb5	215	12	Error	error	NN
cord-346853-0c1qdjb5	215	13	thresholds	threshold	NNS
cord-346853-0c1qdjb5	215	14	and	and	CC
cord-346853-0c1qdjb5	215	15	the	the	DT
cord-346853-0c1qdjb5	215	16	constraints	constraint	NNS
cord-346853-0c1qdjb5	215	17	to	to	IN
cord-346853-0c1qdjb5	215	18	RNA	RNA	NNP
cord-346853-0c1qdjb5	215	19	virus	virus	NN
cord-346853-0c1qdjb5	215	20	evolution	evolution	NN
cord-346853-0c1qdjb5	215	21	Patterns	pattern	NNS
cord-346853-0c1qdjb5	215	22	of	of	IN
cord-346853-0c1qdjb5	215	23	intra	intra	JJ
cord-346853-0c1qdjb5	215	24	-	-	:
cord-346853-0c1qdjb5	215	25	and	and	CC
cord-346853-0c1qdjb5	215	26	inter	inter	JJ
cord-346853-0c1qdjb5	215	27	-	-	JJ
cord-346853-0c1qdjb5	215	28	host	host	JJ
cord-346853-0c1qdjb5	215	29	nonsynonymous	nonsynonymous	JJ
cord-346853-0c1qdjb5	215	30	variation	variation	NN
cord-346853-0c1qdjb5	215	31	reveal	reveal	VBP
cord-346853-0c1qdjb5	215	32	strong	strong	JJ
cord-346853-0c1qdjb5	215	33	purifying	purifying	NN
cord-346853-0c1qdjb5	215	34	selection	selection	NN
cord-346853-0c1qdjb5	215	35	in	in	IN
cord-346853-0c1qdjb5	215	36	dengue	dengue	NN
cord-346853-0c1qdjb5	215	37	virus	virus	NN
cord-346853-0c1qdjb5	216	1	The	the	DT
cord-346853-0c1qdjb5	216	2	phylogeography	phylogeography	NN
cord-346853-0c1qdjb5	216	3	of	of	IN
cord-346853-0c1qdjb5	216	4	human	human	JJ
cord-346853-0c1qdjb5	216	5	viruses	virus	NNS
cord-346853-0c1qdjb5	216	6	Viral	viral	JJ
cord-346853-0c1qdjb5	216	7	evolution	evolution	NN
cord-346853-0c1qdjb5	216	8	and	and	CC
cord-346853-0c1qdjb5	216	9	the	the	DT
cord-346853-0c1qdjb5	216	10	emergence	emergence	NN
cord-346853-0c1qdjb5	216	11	of	of	IN
cord-346853-0c1qdjb5	216	12	SARS	SARS	NNP
cord-346853-0c1qdjb5	216	13	coronavirus	coronavirus	NN
cord-346853-0c1qdjb5	216	14	Genetic	genetic	JJ
cord-346853-0c1qdjb5	216	15	organisation	organisation	NN
cord-346853-0c1qdjb5	216	16	of	of	IN
cord-346853-0c1qdjb5	216	17	a	a	DT
cord-346853-0c1qdjb5	216	18	chimpanzee	chimpanzee	NN
cord-346853-0c1qdjb5	216	19	lentivirus	lentivirus	NN
cord-346853-0c1qdjb5	216	20	related	relate	VBN
cord-346853-0c1qdjb5	216	21	to	to	IN
cord-346853-0c1qdjb5	216	22	HIV-1	HIV-1	NNP
cord-346853-0c1qdjb5	216	23	Recombination	Recombination	NNP
cord-346853-0c1qdjb5	216	24	:	:	:
cord-346853-0c1qdjb5	216	25	multiply	multiply	VB
cord-346853-0c1qdjb5	216	26	infected	infected	JJ
cord-346853-0c1qdjb5	216	27	spleen	spleen	NN
cord-346853-0c1qdjb5	216	28	cells	cell	NNS
cord-346853-0c1qdjb5	216	29	in	in	IN
cord-346853-0c1qdjb5	216	30	HIV	HIV	NNP
cord-346853-0c1qdjb5	216	31	patients	patient	NNS
cord-346853-0c1qdjb5	216	32	Severe	severe	JJ
cord-346853-0c1qdjb5	216	33	acute	acute	JJ
cord-346853-0c1qdjb5	216	34	respiratory	respiratory	JJ
cord-346853-0c1qdjb5	216	35	syndrome	syndrome	NN
cord-346853-0c1qdjb5	216	36	coronavirus	coronavirus	NN
cord-346853-0c1qdjb5	216	37	-	-	HYPH
cord-346853-0c1qdjb5	216	38	like	like	JJ
cord-346853-0c1qdjb5	216	39	virus	virus	NN
cord-346853-0c1qdjb5	216	40	in	in	IN
cord-346853-0c1qdjb5	216	41	Chinese	chinese	JJ
cord-346853-0c1qdjb5	216	42	horseshoe	horseshoe	NN
cord-346853-0c1qdjb5	216	43	bats	bat	NNS
cord-346853-0c1qdjb5	216	44	Bats	bat	NNS
cord-346853-0c1qdjb5	216	45	are	be	VBP
cord-346853-0c1qdjb5	216	46	natural	natural	JJ
cord-346853-0c1qdjb5	216	47	reservoirs	reservoir	NNS
cord-346853-0c1qdjb5	216	48	of	of	IN
cord-346853-0c1qdjb5	216	49	SARS	SARS	NNP
cord-346853-0c1qdjb5	216	50	-	-	HYPH
cord-346853-0c1qdjb5	216	51	like	like	JJ
cord-346853-0c1qdjb5	216	52	coronaviruses	coronaviruse	NNS
cord-346853-0c1qdjb5	217	1	The	the	DT
cord-346853-0c1qdjb5	217	2	rate	rate	NN
cord-346853-0c1qdjb5	217	3	and	and	CC
cord-346853-0c1qdjb5	217	4	character	character	NN
cord-346853-0c1qdjb5	217	5	of	of	IN
cord-346853-0c1qdjb5	217	6	spontaneous	spontaneous	JJ
cord-346853-0c1qdjb5	217	7	mutation	mutation	NN
cord-346853-0c1qdjb5	217	8	in	in	IN
cord-346853-0c1qdjb5	217	9	an	an	DT
cord-346853-0c1qdjb5	217	10	RNA	RNA	NNP
cord-346853-0c1qdjb5	217	11	virus	virus	NN
cord-346853-0c1qdjb5	217	12	A	a	DT
cord-346853-0c1qdjb5	217	13	novel	novel	JJ
cord-346853-0c1qdjb5	217	14	antiviral	antiviral	JJ
cord-346853-0c1qdjb5	217	15	intervention	intervention	NN
cord-346853-0c1qdjb5	217	16	results	result	NNS
cord-346853-0c1qdjb5	217	17	in	in	IN
cord-346853-0c1qdjb5	217	18	more	more	RBR
cord-346853-0c1qdjb5	217	19	accurate	accurate	JJ
cord-346853-0c1qdjb5	217	20	assessment	assessment	NN
cord-346853-0c1qdjb5	217	21	of	of	IN
cord-346853-0c1qdjb5	217	22	human	human	JJ
cord-346853-0c1qdjb5	217	23	immunodeficiency	immunodeficiency	NN
cord-346853-0c1qdjb5	217	24	virus	virus	NN
cord-346853-0c1qdjb5	217	25	type	type	NN
cord-346853-0c1qdjb5	217	26	1	1	CD
cord-346853-0c1qdjb5	217	27	replication	replication	NN
cord-346853-0c1qdjb5	217	28	dynamics	dynamic	NNS
cord-346853-0c1qdjb5	217	29	and	and	CC
cord-346853-0c1qdjb5	217	30	T	t	NN
cord-346853-0c1qdjb5	217	31	-	-	HYPH
cord-346853-0c1qdjb5	217	32	cell	cell	NN
cord-346853-0c1qdjb5	217	33	decay	decay	NN
cord-346853-0c1qdjb5	217	34	in	in	IN
cord-346853-0c1qdjb5	217	35	vivo	vivo	NN
cord-346853-0c1qdjb5	218	1	Avian	avian	JJ
cord-346853-0c1qdjb5	218	2	influenza	influenza	NN
cord-346853-0c1qdjb5	219	1	A	a	DT
cord-346853-0c1qdjb5	219	2	viruses	virus	NNS
cord-346853-0c1qdjb5	219	3	differ	differ	VBP
cord-346853-0c1qdjb5	219	4	from	from	IN
cord-346853-0c1qdjb5	219	5	human	human	JJ
cord-346853-0c1qdjb5	219	6	viruses	virus	NNS
cord-346853-0c1qdjb5	219	7	by	by	IN
cord-346853-0c1qdjb5	219	8	recognition	recognition	NN
cord-346853-0c1qdjb5	219	9	of	of	IN
cord-346853-0c1qdjb5	219	10	sialyloligosaccharides	sialyloligosaccharide	NNS
cord-346853-0c1qdjb5	219	11	and	and	CC
cord-346853-0c1qdjb5	219	12	gangliosides	ganglioside	NNS
cord-346853-0c1qdjb5	219	13	and	and	CC
cord-346853-0c1qdjb5	219	14	by	by	IN
cord-346853-0c1qdjb5	219	15	a	a	DT
cord-346853-0c1qdjb5	219	16	higher	high	JJR
cord-346853-0c1qdjb5	219	17	conservation	conservation	NN
cord-346853-0c1qdjb5	219	18	of	of	IN
cord-346853-0c1qdjb5	219	19	the	the	DT
cord-346853-0c1qdjb5	219	20	HA	HA	NNP
cord-346853-0c1qdjb5	219	21	receptor	receptor	NN
cord-346853-0c1qdjb5	219	22	-	-	HYPH
cord-346853-0c1qdjb5	219	23	binding	bind	VBG
cord-346853-0c1qdjb5	219	24	site	site	NN
cord-346853-0c1qdjb5	219	25	Dengue	dengue	NN
cord-346853-0c1qdjb5	219	26	emergence	emergence	NN
cord-346853-0c1qdjb5	219	27	and	and	CC
cord-346853-0c1qdjb5	219	28	adaptation	adaptation	NN
cord-346853-0c1qdjb5	219	29	to	to	IN
cord-346853-0c1qdjb5	219	30	peridomestic	peridomestic	JJ
cord-346853-0c1qdjb5	219	31	mosquitoes	mosquito	NNS
cord-346853-0c1qdjb5	220	1	Factors	factor	NNS
cord-346853-0c1qdjb5	220	2	in	in	IN
cord-346853-0c1qdjb5	220	3	the	the	DT
cord-346853-0c1qdjb5	220	4	emergence	emergence	NN
cord-346853-0c1qdjb5	220	5	of	of	IN
cord-346853-0c1qdjb5	220	6	infectious	infectious	JJ
cord-346853-0c1qdjb5	220	7	diseases	disease	NNS
cord-346853-0c1qdjb5	221	1	The	the	DT
cord-346853-0c1qdjb5	221	2	population	population	NN
cord-346853-0c1qdjb5	221	3	genetics	genetic	NNS
cord-346853-0c1qdjb5	221	4	and	and	CC
cord-346853-0c1qdjb5	221	5	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	221	6	epidemiology	epidemiology	NN
cord-346853-0c1qdjb5	221	7	of	of	IN
cord-346853-0c1qdjb5	221	8	RNA	RNA	NNP
cord-346853-0c1qdjb5	221	9	viruses	virus	NNS
cord-346853-0c1qdjb5	221	10	Genetic	genetic	JJ
cord-346853-0c1qdjb5	221	11	identification	identification	NN
cord-346853-0c1qdjb5	221	12	of	of	IN
cord-346853-0c1qdjb5	221	13	a	a	DT
cord-346853-0c1qdjb5	221	14	hantavirus	hantavirus	NN
cord-346853-0c1qdjb5	221	15	associated	associate	VBN
cord-346853-0c1qdjb5	221	16	with	with	IN
cord-346853-0c1qdjb5	221	17	an	an	DT
cord-346853-0c1qdjb5	221	18	outbreak	outbreak	NN
cord-346853-0c1qdjb5	221	19	of	of	IN
cord-346853-0c1qdjb5	221	20	acute	acute	JJ
cord-346853-0c1qdjb5	221	21	respiratory	respiratory	JJ
cord-346853-0c1qdjb5	221	22	illness	illness	NN
cord-346853-0c1qdjb5	222	1	The	the	DT
cord-346853-0c1qdjb5	222	2	nearly	nearly	RB
cord-346853-0c1qdjb5	222	3	neutral	neutral	JJ
cord-346853-0c1qdjb5	222	4	theory	theory	NN
cord-346853-0c1qdjb5	222	5	of	of	IN
cord-346853-0c1qdjb5	222	6	molecular	molecular	JJ
cord-346853-0c1qdjb5	222	7	evolution	evolution	NN
cord-346853-0c1qdjb5	222	8	Evolution	evolution	NN
cord-346853-0c1qdjb5	222	9	by	by	IN
cord-346853-0c1qdjb5	222	10	nearly	nearly	RB
cord-346853-0c1qdjb5	222	11	-	-	HYPH
cord-346853-0c1qdjb5	222	12	neutral	neutral	JJ
cord-346853-0c1qdjb5	222	13	mutations	mutation	NNS
cord-346853-0c1qdjb5	223	1	Species	species	NN
cord-346853-0c1qdjb5	223	2	-	-	HYPH
cord-346853-0c1qdjb5	223	3	specific	specific	JJ
cord-346853-0c1qdjb5	223	4	TT	TT	NNP
cord-346853-0c1qdjb5	223	5	viruses	virus	NNS
cord-346853-0c1qdjb5	223	6	and	and	CC
cord-346853-0c1qdjb5	223	7	cross	cross	JJ
cord-346853-0c1qdjb5	223	8	-	-	JJ
cord-346853-0c1qdjb5	223	9	species	species	JJ
cord-346853-0c1qdjb5	223	10	infection	infection	NN
cord-346853-0c1qdjb5	223	11	in	in	IN
cord-346853-0c1qdjb5	223	12	nonhuman	nonhuman	NN
cord-346853-0c1qdjb5	223	13	primates	primate	NNS
cord-346853-0c1qdjb5	224	1	Potential	potential	JJ
cord-346853-0c1qdjb5	224	2	mammalian	mammalian	JJ
cord-346853-0c1qdjb5	224	3	filovirus	filovirus	NN
cord-346853-0c1qdjb5	224	4	reservoirs	reservoir	NNS
cord-346853-0c1qdjb5	224	5	High	high	JJ
cord-346853-0c1qdjb5	224	6	fidelity	fidelity	NN
cord-346853-0c1qdjb5	224	7	of	of	IN
cord-346853-0c1qdjb5	224	8	yellow	yellow	JJ
cord-346853-0c1qdjb5	224	9	fever	fever	NNP
cord-346853-0c1qdjb5	224	10	virus	virus	NN
cord-346853-0c1qdjb5	224	11	RNA	rna	NN
cord-346853-0c1qdjb5	224	12	polymerase	polymerase	NN
cord-346853-0c1qdjb5	225	1	García	García	NNP
cord-346853-0c1qdjb5	225	2	-	-	HYPH
cord-346853-0c1qdjb5	225	3	Arenal	Arenal	NNP
cord-346853-0c1qdjb5	225	4	F	F	NNP
cord-346853-0c1qdjb5	225	5	(	(	-LRB-
cord-346853-0c1qdjb5	225	6	1999	1999	CD
cord-346853-0c1qdjb5	225	7	)	)	-RRB-
cord-346853-0c1qdjb5	226	1	Genetic	genetic	JJ
cord-346853-0c1qdjb5	226	2	variability	variability	NN
cord-346853-0c1qdjb5	226	3	of	of	IN
cord-346853-0c1qdjb5	226	4	natural	natural	JJ
cord-346853-0c1qdjb5	226	5	populations	population	NNS
cord-346853-0c1qdjb5	226	6	of	of	IN
cord-346853-0c1qdjb5	226	7	cotton	cotton	NN
cord-346853-0c1qdjb5	226	8	leaf	leaf	NN
cord-346853-0c1qdjb5	226	9	curl	curl	NN
cord-346853-0c1qdjb5	226	10	geminivirus	geminivirus	NNP
cord-346853-0c1qdjb5	226	11	,	,	,
cord-346853-0c1qdjb5	226	12	a	a	DT
cord-346853-0c1qdjb5	226	13	single	single	RB
cord-346853-0c1qdjb5	226	14	-	-	HYPH
cord-346853-0c1qdjb5	226	15	stranded	strand	VBN
cord-346853-0c1qdjb5	226	16	DNA	dna	NN
cord-346853-0c1qdjb5	226	17	virus	virus	NN
cord-346853-0c1qdjb5	226	18	Analysis	analysis	NN
cord-346853-0c1qdjb5	226	19	of	of	IN
cord-346853-0c1qdjb5	226	20	influenza	influenza	NN
cord-346853-0c1qdjb5	226	21	A	a	DT
cord-346853-0c1qdjb5	226	22	virus	virus	NN
cord-346853-0c1qdjb5	226	23	nucleoproteins	nucleoprotein	VBZ
cord-346853-0c1qdjb5	226	24	for	for	IN
cord-346853-0c1qdjb5	226	25	the	the	DT
cord-346853-0c1qdjb5	226	26	assessment	assessment	NN
cord-346853-0c1qdjb5	226	27	of	of	IN
cord-346853-0c1qdjb5	226	28	molecular	molecular	JJ
cord-346853-0c1qdjb5	226	29	genetic	genetic	JJ
cord-346853-0c1qdjb5	226	30	mechanisms	mechanism	NNS
cord-346853-0c1qdjb5	226	31	leading	lead	VBG
cord-346853-0c1qdjb5	226	32	to	to	IN
cord-346853-0c1qdjb5	226	33	new	new	JJ
cord-346853-0c1qdjb5	226	34	phylogenetic	phylogenetic	JJ
cord-346853-0c1qdjb5	226	35	virus	virus	NN
cord-346853-0c1qdjb5	226	36	lineages	lineage	NNS
cord-346853-0c1qdjb5	226	37	High	high	JJ
cord-346853-0c1qdjb5	226	38	rate	rate	NN
cord-346853-0c1qdjb5	226	39	of	of	IN
cord-346853-0c1qdjb5	226	40	viral	viral	JJ
cord-346853-0c1qdjb5	226	41	evolution	evolution	NN
cord-346853-0c1qdjb5	226	42	associated	associate	VBN
cord-346853-0c1qdjb5	226	43	with	with	IN
cord-346853-0c1qdjb5	226	44	the	the	DT
cord-346853-0c1qdjb5	226	45	emergence	emergence	NN
cord-346853-0c1qdjb5	226	46	of	of	IN
cord-346853-0c1qdjb5	226	47	canine	canine	JJ
cord-346853-0c1qdjb5	226	48	parvoviruses	parvovirus	NNS
cord-346853-0c1qdjb5	227	1	The	the	DT
cord-346853-0c1qdjb5	227	2	origins	origin	NNS
cord-346853-0c1qdjb5	227	3	of	of	IN
cord-346853-0c1qdjb5	227	4	acquired	acquire	VBN
cord-346853-0c1qdjb5	227	5	immune	immune	JJ
cord-346853-0c1qdjb5	227	6	deficiency	deficiency	NN
cord-346853-0c1qdjb5	227	7	syndrome	syndrome	NN
cord-346853-0c1qdjb5	227	8	viruses	virus	NNS
cord-346853-0c1qdjb5	227	9	:	:	:
cord-346853-0c1qdjb5	227	10	where	where	WRB
cord-346853-0c1qdjb5	227	11	and	and	CC
cord-346853-0c1qdjb5	227	12	when	when	WRB
cord-346853-0c1qdjb5	227	13	Evidence	evidence	NN
cord-346853-0c1qdjb5	227	14	from	from	IN
cord-346853-0c1qdjb5	227	15	the	the	DT
cord-346853-0c1qdjb5	227	16	evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	227	17	analysis	analysis	NN
cord-346853-0c1qdjb5	227	18	of	of	IN
cord-346853-0c1qdjb5	227	19	nucleotide	nucleotide	JJ
cord-346853-0c1qdjb5	227	20	sequences	sequence	NNS
cord-346853-0c1qdjb5	227	21	for	for	IN
cord-346853-0c1qdjb5	227	22	a	a	DT
cord-346853-0c1qdjb5	227	23	recombinant	recombinant	JJ
cord-346853-0c1qdjb5	227	24	history	history	NN
cord-346853-0c1qdjb5	227	25	of	of	IN
cord-346853-0c1qdjb5	227	26	SARS	SARS	NNP
cord-346853-0c1qdjb5	227	27	-	-	HYPH
cord-346853-0c1qdjb5	227	28	CoV	CoV	NNP
cord-346853-0c1qdjb5	227	29	Infect	infect	VBP
cord-346853-0c1qdjb5	227	30	Mosaic	Mosaic	NNP
cord-346853-0c1qdjb5	227	31	evolution	evolution	NN
cord-346853-0c1qdjb5	227	32	of	of	IN
cord-346853-0c1qdjb5	227	33	the	the	DT
cord-346853-0c1qdjb5	227	34	severe	severe	JJ
cord-346853-0c1qdjb5	227	35	acute	acute	JJ
cord-346853-0c1qdjb5	227	36	respiratory	respiratory	JJ
cord-346853-0c1qdjb5	227	37	syndrome	syndrome	NN
cord-346853-0c1qdjb5	227	38	coronavirus	coronavirus	NN
cord-346853-0c1qdjb5	227	39	Ancient	Ancient	NNP
cord-346853-0c1qdjb5	227	40	co	co	NN
cord-346853-0c1qdjb5	227	41	-	-	NN
cord-346853-0c1qdjb5	227	42	speciation	speciation	NN
cord-346853-0c1qdjb5	227	43	of	of	IN
cord-346853-0c1qdjb5	227	44	simian	simian	JJ
cord-346853-0c1qdjb5	227	45	foamy	foamy	NN
cord-346853-0c1qdjb5	227	46	viruses	virus	NNS
cord-346853-0c1qdjb5	227	47	and	and	CC
cord-346853-0c1qdjb5	227	48	primates	primate	NNS
cord-346853-0c1qdjb5	227	49	Characterization	characterization	NN
cord-346853-0c1qdjb5	227	50	of	of	IN
cord-346853-0c1qdjb5	227	51	the	the	DT
cord-346853-0c1qdjb5	227	52	1918	1918	CD
cord-346853-0c1qdjb5	227	53	influenza	influenza	NN
cord-346853-0c1qdjb5	227	54	virus	virus	NN
cord-346853-0c1qdjb5	227	55	polymerase	polymerase	NN
cord-346853-0c1qdjb5	227	56	genes	gene	NNS
cord-346853-0c1qdjb5	227	57	Phylogenetic	phylogenetic	JJ
cord-346853-0c1qdjb5	227	58	relationships	relationship	NNS
cord-346853-0c1qdjb5	227	59	and	and	CC
cord-346853-0c1qdjb5	227	60	differential	differential	NN
cord-346853-0c1qdjb5	227	61	selection	selection	NN
cord-346853-0c1qdjb5	227	62	pressures	pressure	NNS
cord-346853-0c1qdjb5	227	63	among	among	IN
cord-346853-0c1qdjb5	227	64	genotypes	genotype	NNS
cord-346853-0c1qdjb5	227	65	of	of	IN
cord-346853-0c1qdjb5	227	66	dengue-2	dengue-2	NNP
cord-346853-0c1qdjb5	227	67	virus	virus	NN
cord-346853-0c1qdjb5	227	68	Evolutionary	evolutionary	JJ
cord-346853-0c1qdjb5	227	69	relationships	relationship	NNS
cord-346853-0c1qdjb5	227	70	of	of	IN
cord-346853-0c1qdjb5	227	71	endemic	endemic	JJ
cord-346853-0c1qdjb5	227	72	/	/	SYM
cord-346853-0c1qdjb5	227	73	epidemic	epidemic	NN
cord-346853-0c1qdjb5	227	74	and	and	CC
cord-346853-0c1qdjb5	227	75	sylvatic	sylvatic	JJ
cord-346853-0c1qdjb5	227	76	dengue	dengue	NN
cord-346853-0c1qdjb5	227	77	viruses	virus	NNS
cord-346853-0c1qdjb5	227	78	Kinetics	kinetic	NNS
cord-346853-0c1qdjb5	227	79	of	of	IN
cord-346853-0c1qdjb5	227	80	acute	acute	JJ
cord-346853-0c1qdjb5	227	81	hepatitis	hepatitis	NN
cord-346853-0c1qdjb5	227	82	B	b	NN
cord-346853-0c1qdjb5	227	83	virus	virus	NN
cord-346853-0c1qdjb5	227	84	infection	infection	NN
cord-346853-0c1qdjb5	227	85	in	in	IN
cord-346853-0c1qdjb5	227	86	humans	human	NNS
cord-346853-0c1qdjb5	227	87	Emergence	Emergence	NNP
cord-346853-0c1qdjb5	227	88	of	of	IN
cord-346853-0c1qdjb5	227	89	influenza	influenza	NN
cord-346853-0c1qdjb5	227	90	A	a	DT
cord-346853-0c1qdjb5	227	91	viruses	virus	NNS
cord-346853-0c1qdjb5	228	1	Reduced	reduce	VBN
cord-346853-0c1qdjb5	228	2	positive	positive	JJ
cord-346853-0c1qdjb5	228	3	selection	selection	NN
cord-346853-0c1qdjb5	228	4	in	in	IN
cord-346853-0c1qdjb5	228	5	vector	vector	NN
cord-346853-0c1qdjb5	228	6	-	-	HYPH
cord-346853-0c1qdjb5	228	7	borne	bear	VBN
cord-346853-0c1qdjb5	228	8	RNA	RNA	NNP
cord-346853-0c1qdjb5	228	9	viruses	virus	NNS
cord-346853-0c1qdjb5	228	10	Population	population	NN
cord-346853-0c1qdjb5	228	11	biology	biology	NN
cord-346853-0c1qdjb5	228	12	of	of	IN
cord-346853-0c1qdjb5	228	13	multihost	multihost	NN
cord-346853-0c1qdjb5	228	14	pathogens	pathogen	NNS
cord-346853-0c1qdjb5	228	15	Population	population	NN
cord-346853-0c1qdjb5	228	16	biology	biology	NN
cord-346853-0c1qdjb5	228	17	of	of	IN
cord-346853-0c1qdjb5	228	18	emerging	emerge	VBG
cord-346853-0c1qdjb5	228	19	and	and	CC
cord-346853-0c1qdjb5	228	20	re	re	JJ
cord-346853-0c1qdjb5	228	21	-	-	JJ
cord-346853-0c1qdjb5	228	22	emerging	emerge	VBG
cord-346853-0c1qdjb5	228	23	pathogens	pathogen	NNS
cord-346853-0c1qdjb5	228	24	Characterization	characterization	NN
cord-346853-0c1qdjb5	228	25	of	of	IN
cord-346853-0c1qdjb5	228	26	severe	severe	JJ
cord-346853-0c1qdjb5	228	27	acute	acute	JJ
cord-346853-0c1qdjb5	228	28	respiratory	respiratory	JJ
cord-346853-0c1qdjb5	228	29	syndrome	syndrome	NN
cord-346853-0c1qdjb5	228	30	coronavirus	coronavirus	NN
cord-346853-0c1qdjb5	228	31	genomes	genome	NNS
cord-346853-0c1qdjb5	228	32	in	in	IN
cord-346853-0c1qdjb5	228	33	Taiwan	Taiwan	NNP
cord-346853-0c1qdjb5	228	34	:	:	:
cord-346853-0c1qdjb5	229	1	Molecular	molecular	JJ
cord-346853-0c1qdjb5	229	2	epidemiology	epidemiology	NN
cord-346853-0c1qdjb5	229	3	and	and	CC
cord-346853-0c1qdjb5	230	1	genome	genome	NNP
cord-346853-0c1qdjb5	230	2	evolution	evolution	NN
cord-346853-0c1qdjb5	230	3	Vesicular	Vesicular	NNP
cord-346853-0c1qdjb5	230	4	stomatitis	stomatitis	NN
cord-346853-0c1qdjb5	230	5	virus	virus	NN
cord-346853-0c1qdjb5	230	6	evolution	evolution	NN
cord-346853-0c1qdjb5	230	7	during	during	IN
cord-346853-0c1qdjb5	230	8	alternation	alternation	NN
cord-346853-0c1qdjb5	230	9	between	between	IN
cord-346853-0c1qdjb5	230	10	persistent	persistent	JJ
cord-346853-0c1qdjb5	230	11	Infection	infection	NN
cord-346853-0c1qdjb5	230	12	in	in	IN
cord-346853-0c1qdjb5	230	13	insect	insect	NN
cord-346853-0c1qdjb5	230	14	cells	cell	NNS
cord-346853-0c1qdjb5	230	15	and	and	CC
cord-346853-0c1qdjb5	230	16	acute	acute	JJ
cord-346853-0c1qdjb5	230	17	infection	infection	NN
cord-346853-0c1qdjb5	230	18	in	in	IN
cord-346853-0c1qdjb5	230	19	mammalian	mammalian	JJ
cord-346853-0c1qdjb5	230	20	cells	cell	NNS
cord-346853-0c1qdjb5	230	21	Is	be	VBZ
cord-346853-0c1qdjb5	230	22	dominated	dominate	VBN
cord-346853-0c1qdjb5	230	23	by	by	IN
cord-346853-0c1qdjb5	230	24	the	the	DT
cord-346853-0c1qdjb5	230	25	persistence	persistence	NN
cord-346853-0c1qdjb5	230	26	phase	phase	NN
cord-346853-0c1qdjb5	230	27	Acknowledgements	acknowledgement	NNS
cord-346853-0c1qdjb5	231	1	We	-PRON-	PRP
cord-346853-0c1qdjb5	231	2	thank	thank	VBP
cord-346853-0c1qdjb5	231	3	The	the	DT
cord-346853-0c1qdjb5	231	4	Wellcome	Wellcome	NNP
cord-346853-0c1qdjb5	231	5	Trust	Trust	NNP
cord-346853-0c1qdjb5	231	6	for	for	IN
cord-346853-0c1qdjb5	231	7	financial	financial	JJ
cord-346853-0c1qdjb5	231	8	support	support	NN
cord-346853-0c1qdjb5	231	9	.	.	.
cord-346853-0c1qdjb5	231	10	 	 	_SP