id	sid	tid	token	lemma	pos
cord-326228-9x1233q6	1	1	key	key	JJ
cord-326228-9x1233q6	1	2	:	:	:
cord-326228-9x1233q6	1	3	cord-326228	cord-326228	NNP
cord-326228-9x1233q6	1	4	-	-	HYPH
cord-326228-9x1233q6	1	5	9x1233q6	9x1233q6	CD
cord-326228-9x1233q6	1	6	authors	author	NNS
cord-326228-9x1233q6	1	7	:	:	:
cord-326228-9x1233q6	1	8	Holley	Holley	NNP
cord-326228-9x1233q6	1	9	,	,	,
cord-326228-9x1233q6	1	10	Caroline	Caroline	NNP
cord-326228-9x1233q6	1	11	L	L	NNP
cord-326228-9x1233q6	1	12	;	;	:
cord-326228-9x1233q6	1	13	Schroder	Schroder	NNP
cord-326228-9x1233q6	1	14	,	,	,
cord-326228-9x1233q6	1	15	Kate	Kate	NNP
cord-326228-9x1233q6	1	16	title	title	NN
cord-326228-9x1233q6	1	17	:	:	:
cord-326228-9x1233q6	2	1	The	the	DT
cord-326228-9x1233q6	2	2	rOX‐stars	rox‐star	NNS
cord-326228-9x1233q6	2	3	of	of	IN
cord-326228-9x1233q6	2	4	inflammation	inflammation	NN
cord-326228-9x1233q6	2	5	:	:	:
cord-326228-9x1233q6	2	6	links	link	NNS
cord-326228-9x1233q6	2	7	between	between	IN
cord-326228-9x1233q6	2	8	the	the	DT
cord-326228-9x1233q6	2	9	inflammasome	inflammasome	NN
cord-326228-9x1233q6	2	10	and	and	CC
cord-326228-9x1233q6	2	11	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	2	12	meltdown	meltdown	NN
cord-326228-9x1233q6	2	13	date	date	NN
cord-326228-9x1233q6	2	14	:	:	:
cord-326228-9x1233q6	2	15	2020	2020	CD
cord-326228-9x1233q6	2	16	-	-	HYPH
cord-326228-9x1233q6	2	17	02	02	CD
cord-326228-9x1233q6	2	18	-	-	SYM
cord-326228-9x1233q6	2	19	10	10	CD
cord-326228-9x1233q6	2	20	journal	journal	NN
cord-326228-9x1233q6	2	21	:	:	:
cord-326228-9x1233q6	2	22	Clin	Clin	NNP
cord-326228-9x1233q6	2	23	Transl	Transl	NNP
cord-326228-9x1233q6	2	24	Immunology	Immunology	NNP
cord-326228-9x1233q6	2	25	DOI	DOI	NNP
cord-326228-9x1233q6	2	26	:	:	:
cord-326228-9x1233q6	2	27	10.1002/	10.1002/	CD
cord-326228-9x1233q6	3	1	cti2.1109	cti2.1109	NNP
cord-326228-9x1233q6	3	2	sha	sha	NNP
cord-326228-9x1233q6	3	3	:	:	:
cord-326228-9x1233q6	4	1	a6f40ea4a3c00f065ee24e7be886e3cc48a3a6bd	a6f40ea4a3c00f065ee24e7be886e3cc48a3a6bd	NNP
cord-326228-9x1233q6	5	1	doc_id	doc_id	CD
cord-326228-9x1233q6	5	2	:	:	:
cord-326228-9x1233q6	5	3	326228	326228	CD
cord-326228-9x1233q6	5	4	cord_uid	cord_uid	FW
cord-326228-9x1233q6	5	5	:	:	:
cord-326228-9x1233q6	6	1	9x1233q6	9x1233q6	CD
cord-326228-9x1233q6	7	1	The	the	DT
cord-326228-9x1233q6	7	2	nod‐like	nod‐like	NNP
cord-326228-9x1233q6	7	3	receptor	receptor	NN
cord-326228-9x1233q6	7	4	protein	protein	NN
cord-326228-9x1233q6	7	5	3	3	CD
cord-326228-9x1233q6	8	1	(	(	-LRB-
cord-326228-9x1233q6	8	2	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	8	3	)	)	-RRB-
cord-326228-9x1233q6	8	4	inflammasome	inflammasome	NN
cord-326228-9x1233q6	8	5	drives	drive	VBZ
cord-326228-9x1233q6	8	6	inflammation	inflammation	NN
cord-326228-9x1233q6	8	7	in	in	IN
cord-326228-9x1233q6	8	8	response	response	NN
cord-326228-9x1233q6	8	9	to	to	IN
cord-326228-9x1233q6	8	10	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	8	11	dysfunction	dysfunction	NN
cord-326228-9x1233q6	8	12	.	.	.
cord-326228-9x1233q6	9	1	As	as	IN
cord-326228-9x1233q6	9	2	metabolic	metabolic	JJ
cord-326228-9x1233q6	9	3	powerhouses	powerhouse	NNS
cord-326228-9x1233q6	9	4	with	with	IN
cord-326228-9x1233q6	9	5	prokaryotic	prokaryotic	JJ
cord-326228-9x1233q6	9	6	ancestry	ancestry	NN
cord-326228-9x1233q6	9	7	,	,	,
cord-326228-9x1233q6	9	8	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	9	9	are	be	VBP
cord-326228-9x1233q6	9	10	a	a	DT
cord-326228-9x1233q6	9	11	cache	cache	NN
cord-326228-9x1233q6	9	12	for	for	IN
cord-326228-9x1233q6	9	13	danger‐associated	danger‐associated	JJ
cord-326228-9x1233q6	9	14	molecular	molecular	JJ
cord-326228-9x1233q6	9	15	patterns	pattern	NNS
cord-326228-9x1233q6	9	16	and	and	CC
cord-326228-9x1233q6	9	17	pathogen‐associated	pathogen‐associated	JJ
cord-326228-9x1233q6	9	18	molecular	molecular	JJ
cord-326228-9x1233q6	9	19	pattern‐like	pattern‐like	NNP
cord-326228-9x1233q6	9	20	molecules	molecule	NNS
cord-326228-9x1233q6	9	21	that	that	WDT
cord-326228-9x1233q6	9	22	elicit	elicit	VBP
cord-326228-9x1233q6	9	23	potent	potent	JJ
cord-326228-9x1233q6	9	24	innate	innate	JJ
cord-326228-9x1233q6	9	25	immune	immune	JJ
cord-326228-9x1233q6	9	26	responses	response	NNS
cord-326228-9x1233q6	9	27	.	.	.
cord-326228-9x1233q6	10	1	Persistent	persistent	JJ
cord-326228-9x1233q6	10	2	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	10	3	damage	damage	NN
cord-326228-9x1233q6	10	4	caused	cause	VBN
cord-326228-9x1233q6	10	5	by	by	IN
cord-326228-9x1233q6	10	6	infection	infection	NN
cord-326228-9x1233q6	10	7	,	,	,
cord-326228-9x1233q6	10	8	or	or	CC
cord-326228-9x1233q6	10	9	genetic	genetic	JJ
cord-326228-9x1233q6	10	10	or	or	CC
cord-326228-9x1233q6	10	11	environmental	environmental	JJ
cord-326228-9x1233q6	10	12	factors	factor	NNS
cord-326228-9x1233q6	10	13	,	,	,
cord-326228-9x1233q6	10	14	can	can	MD
cord-326228-9x1233q6	10	15	lead	lead	VB
cord-326228-9x1233q6	10	16	to	to	IN
cord-326228-9x1233q6	10	17	inappropriate	inappropriate	JJ
cord-326228-9x1233q6	10	18	or	or	CC
cord-326228-9x1233q6	10	19	sustained	sustained	JJ
cord-326228-9x1233q6	10	20	inflammasome	inflammasome	NN
cord-326228-9x1233q6	10	21	signalling	signalling	NN
cord-326228-9x1233q6	10	22	.	.	.
cord-326228-9x1233q6	11	1	Here	here	RB
cord-326228-9x1233q6	11	2	,	,	,
cord-326228-9x1233q6	11	3	we	-PRON-	PRP
cord-326228-9x1233q6	11	4	review	review	VBP
cord-326228-9x1233q6	11	5	the	the	DT
cord-326228-9x1233q6	11	6	features	feature	NNS
cord-326228-9x1233q6	11	7	of	of	IN
cord-326228-9x1233q6	11	8	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	11	9	that	that	WDT
cord-326228-9x1233q6	11	10	drive	drive	VBP
cord-326228-9x1233q6	11	11	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	11	12	signalling	signalling	NN
cord-326228-9x1233q6	11	13	,	,	,
cord-326228-9x1233q6	11	14	with	with	IN
cord-326228-9x1233q6	11	15	a	a	DT
cord-326228-9x1233q6	11	16	particular	particular	JJ
cord-326228-9x1233q6	11	17	focus	focus	NN
cord-326228-9x1233q6	11	18	on	on	IN
cord-326228-9x1233q6	11	19	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	11	20	activation	activation	NN
cord-326228-9x1233q6	11	21	of	of	IN
cord-326228-9x1233q6	11	22	the	the	DT
cord-326228-9x1233q6	11	23	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	11	24	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	11	25	.	.	.
cord-326228-9x1233q6	12	1	Given	give	VBN
cord-326228-9x1233q6	12	2	that	that	DT
cord-326228-9x1233q6	12	3	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	12	4	network	network	NN
cord-326228-9x1233q6	12	5	dynamics	dynamic	NNS
cord-326228-9x1233q6	12	6	,	,	,
cord-326228-9x1233q6	12	7	metabolic	metabolic	JJ
cord-326228-9x1233q6	12	8	activity	activity	NN
cord-326228-9x1233q6	12	9	and	and	CC
cord-326228-9x1233q6	12	10	redox	redox	NN
cord-326228-9x1233q6	12	11	state	state	NN
cord-326228-9x1233q6	12	12	are	be	VBP
cord-326228-9x1233q6	12	13	all	all	DT
cord-326228-9x1233q6	12	14	intricately	intricately	RB
cord-326228-9x1233q6	12	15	linked	link	VBN
cord-326228-9x1233q6	12	16	to	to	IN
cord-326228-9x1233q6	12	17	each	each	DT
cord-326228-9x1233q6	12	18	other	other	JJ
cord-326228-9x1233q6	12	19	and	and	CC
cord-326228-9x1233q6	12	20	to	to	IN
cord-326228-9x1233q6	12	21	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	12	22	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	12	23	activity	activity	NN
cord-326228-9x1233q6	12	24	,	,	,
cord-326228-9x1233q6	12	25	we	-PRON-	PRP
cord-326228-9x1233q6	12	26	highlight	highlight	VBP
cord-326228-9x1233q6	12	27	the	the	DT
cord-326228-9x1233q6	12	28	importance	importance	NN
cord-326228-9x1233q6	12	29	of	of	IN
cord-326228-9x1233q6	12	30	a	a	DT
cord-326228-9x1233q6	12	31	holistic	holistic	JJ
cord-326228-9x1233q6	12	32	approach	approach	NN
cord-326228-9x1233q6	12	33	to	to	IN
cord-326228-9x1233q6	12	34	investigations	investigation	NNS
cord-326228-9x1233q6	12	35	of	of	IN
cord-326228-9x1233q6	12	36	NLRP3	nlrp3	NN
cord-326228-9x1233q6	12	37	activation	activation	NN
cord-326228-9x1233q6	12	38	by	by	IN
cord-326228-9x1233q6	12	39	dysfunctional	dysfunctional	JJ
cord-326228-9x1233q6	12	40	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	12	41	.	.	.
cord-326228-9x1233q6	13	1	Mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	13	2	are	be	VBP
cord-326228-9x1233q6	13	3	hubs	hub	NNS
cord-326228-9x1233q6	13	4	for	for	IN
cord-326228-9x1233q6	13	5	metabolic	metabolic	JJ
cord-326228-9x1233q6	13	6	activity	activity	NN
cord-326228-9x1233q6	13	7	,	,	,
cord-326228-9x1233q6	13	8	where	where	WRB
cord-326228-9x1233q6	13	9	they	-PRON-	PRP
cord-326228-9x1233q6	13	10	produce	produce	VBP
cord-326228-9x1233q6	13	11	ATP	ATP	NNP
cord-326228-9x1233q6	13	12	required	require	VBN
cord-326228-9x1233q6	13	13	for	for	IN
cord-326228-9x1233q6	13	14	cellular	cellular	JJ
cord-326228-9x1233q6	13	15	functions	function	NNS
cord-326228-9x1233q6	13	16	.	.	.
cord-326228-9x1233q6	14	1	Mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	14	2	are	be	VBP
cord-326228-9x1233q6	14	3	unique	unique	JJ
cord-326228-9x1233q6	14	4	amongst	amongst	IN
cord-326228-9x1233q6	14	5	cellular	cellular	JJ
cord-326228-9x1233q6	14	6	organelles	organelle	NNS
cord-326228-9x1233q6	14	7	,	,	,
cord-326228-9x1233q6	14	8	as	as	IN
cord-326228-9x1233q6	14	9	they	-PRON-	PRP
cord-326228-9x1233q6	14	10	are	be	VBP
cord-326228-9x1233q6	14	11	ancestrally	ancestrally	RB
cord-326228-9x1233q6	14	12	derived	derive	VBN
cord-326228-9x1233q6	14	13	from	from	IN
cord-326228-9x1233q6	14	14	a	a	DT
cord-326228-9x1233q6	14	15	bacterial	bacterial	JJ
cord-326228-9x1233q6	14	16	endosymbiont	endosymbiont	NN
cord-326228-9x1233q6	14	17	that	that	WDT
cord-326228-9x1233q6	14	18	integrated	integrate	VBD
cord-326228-9x1233q6	14	19	with	with	IN
cord-326228-9x1233q6	14	20	an	an	DT
cord-326228-9x1233q6	14	21	early	early	JJ
cord-326228-9x1233q6	14	22	eukaryote	eukaryote	NN
cord-326228-9x1233q6	14	23	precursor	precursor	NN
cord-326228-9x1233q6	14	24	.	.	.
cord-326228-9x1233q6	15	1	1	1	LS
cord-326228-9x1233q6	16	1	Many	many	JJ
cord-326228-9x1233q6	16	2	components	component	NNS
cord-326228-9x1233q6	16	3	of	of	IN
cord-326228-9x1233q6	16	4	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	16	5	have	have	VBP
cord-326228-9x1233q6	16	6	their	-PRON-	PRP$
cord-326228-9x1233q6	16	7	origins	origin	NNS
cord-326228-9x1233q6	16	8	in	in	IN
cord-326228-9x1233q6	16	9	the	the	DT
cord-326228-9x1233q6	16	10	mitochondrion	mitochondrion	NN
cord-326228-9x1233q6	16	11	's	's	POS
cord-326228-9x1233q6	16	12	bacterial	bacterial	JJ
cord-326228-9x1233q6	16	13	ancestry	ancestry	NN
cord-326228-9x1233q6	16	14	,	,	,
cord-326228-9x1233q6	16	15	such	such	JJ
cord-326228-9x1233q6	16	16	as	as	IN
cord-326228-9x1233q6	16	17	CpG	CpG	NNP
cord-326228-9x1233q6	16	18	-	-	HYPH
cord-326228-9x1233q6	16	19	rich	rich	JJ
cord-326228-9x1233q6	16	20	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	16	21	DNA	dna	NN
cord-326228-9x1233q6	16	22	(	(	-LRB-
cord-326228-9x1233q6	16	23	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	16	24	)	)	-RRB-
cord-326228-9x1233q6	16	25	in	in	IN
cord-326228-9x1233q6	16	26	the	the	DT
cord-326228-9x1233q6	16	27	matrix	matrix	NN
cord-326228-9x1233q6	16	28	and	and	CC
cord-326228-9x1233q6	16	29	cardiolipin	cardiolipin	NN
cord-326228-9x1233q6	16	30	in	in	IN
cord-326228-9x1233q6	16	31	the	the	DT
cord-326228-9x1233q6	16	32	inner	inner	JJ
cord-326228-9x1233q6	16	33	membrane	membrane	NN
cord-326228-9x1233q6	16	34	.	.	.
cord-326228-9x1233q6	17	1	Such	such	JJ
cord-326228-9x1233q6	17	2	bacterially	bacterially	RB
cord-326228-9x1233q6	17	3	derived	derive	VBN
cord-326228-9x1233q6	17	4	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	17	5	molecules	molecule	NNS
cord-326228-9x1233q6	17	6	can	can	MD
cord-326228-9x1233q6	17	7	induce	induce	VB
cord-326228-9x1233q6	17	8	important	important	JJ
cord-326228-9x1233q6	17	9	immunomodulatory	immunomodulatory	JJ
cord-326228-9x1233q6	17	10	mechanisms	mechanism	NNS
cord-326228-9x1233q6	17	11	.	.	.
cord-326228-9x1233q6	18	1	2	2	LS
cord-326228-9x1233q6	19	1	Host	host	NN
cord-326228-9x1233q6	19	2	pattern	pattern	NN
cord-326228-9x1233q6	19	3	recognition	recognition	NN
cord-326228-9x1233q6	19	4	receptors	receptor	NNS
cord-326228-9x1233q6	19	5	(	(	-LRB-
cord-326228-9x1233q6	19	6	PRRs	PRRs	NNP
cord-326228-9x1233q6	19	7	)	)	-RRB-
cord-326228-9x1233q6	19	8	are	be	VBP
cord-326228-9x1233q6	19	9	at	at	IN
cord-326228-9x1233q6	19	10	the	the	DT
cord-326228-9x1233q6	19	11	interface	interface	NN
cord-326228-9x1233q6	19	12	between	between	IN
cord-326228-9x1233q6	19	13	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	19	14	and	and	CC
cord-326228-9x1233q6	19	15	innate	innate	JJ
cord-326228-9x1233q6	19	16	immunity	immunity	NN
cord-326228-9x1233q6	19	17	.	.	.
cord-326228-9x1233q6	20	1	PRRs	prr	NNS
cord-326228-9x1233q6	20	2	have	have	VBP
cord-326228-9x1233q6	20	3	evolved	evolve	VBN
cord-326228-9x1233q6	20	4	to	to	TO
cord-326228-9x1233q6	20	5	recognise	recognise	VB
cord-326228-9x1233q6	20	6	and	and	CC
cord-326228-9x1233q6	20	7	respond	respond	VB
cord-326228-9x1233q6	20	8	to	to	IN
cord-326228-9x1233q6	20	9	foreign	foreign	JJ
cord-326228-9x1233q6	20	10	agents	agent	NNS
cord-326228-9x1233q6	20	11	(	(	-LRB-
cord-326228-9x1233q6	20	12	pathogen	pathogen	NN
cord-326228-9x1233q6	20	13	-	-	HYPH
cord-326228-9x1233q6	20	14	associated	associate	VBN
cord-326228-9x1233q6	20	15	molecular	molecular	JJ
cord-326228-9x1233q6	20	16	patterns	pattern	NNS
cord-326228-9x1233q6	20	17	;	;	:
cord-326228-9x1233q6	20	18	PAMPs	pamp	NNS
cord-326228-9x1233q6	20	19	)	)	-RRB-
cord-326228-9x1233q6	20	20	and	and	CC
cord-326228-9x1233q6	20	21	specific	specific	JJ
cord-326228-9x1233q6	20	22	'	'	``
cord-326228-9x1233q6	20	23	self	self	NN
cord-326228-9x1233q6	20	24	'	'	''
cord-326228-9x1233q6	20	25	molecules	molecule	NNS
cord-326228-9x1233q6	20	26	whose	whose	WP$
cord-326228-9x1233q6	20	27	mislocalisation	mislocalisation	NN
cord-326228-9x1233q6	20	28	or	or	CC
cord-326228-9x1233q6	20	29	modification	modification	NN
cord-326228-9x1233q6	20	30	indicates	indicate	VBZ
cord-326228-9x1233q6	20	31	cell	cell	NN
cord-326228-9x1233q6	20	32	stress	stress	NN
cord-326228-9x1233q6	20	33	or	or	CC
cord-326228-9x1233q6	20	34	infection	infection	NN
cord-326228-9x1233q6	20	35	(	(	-LRB-
cord-326228-9x1233q6	20	36	danger	danger	NN
cord-326228-9x1233q6	20	37	-	-	HYPH
cord-326228-9x1233q6	20	38	associated	associate	VBN
cord-326228-9x1233q6	20	39	molecular	molecular	JJ
cord-326228-9x1233q6	20	40	patterns	pattern	NNS
cord-326228-9x1233q6	20	41	;	;	:
cord-326228-9x1233q6	20	42	DAMPs	damps	ADD
cord-326228-9x1233q6	20	43	)	)	-RRB-
cord-326228-9x1233q6	20	44	.	.	.
cord-326228-9x1233q6	21	1	Nod	nod	JJ
cord-326228-9x1233q6	21	2	-	-	HYPH
cord-326228-9x1233q6	21	3	like	like	JJ
cord-326228-9x1233q6	21	4	receptor	receptor	NN
cord-326228-9x1233q6	21	5	protein	protein	NN
cord-326228-9x1233q6	21	6	3	3	CD
cord-326228-9x1233q6	21	7	(	(	-LRB-
cord-326228-9x1233q6	21	8	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	21	9	)	)	-RRB-
cord-326228-9x1233q6	21	10	is	be	VBZ
cord-326228-9x1233q6	21	11	a	a	DT
cord-326228-9x1233q6	21	12	cytosolic	cytosolic	JJ
cord-326228-9x1233q6	21	13	PRR	PRR	NNP
cord-326228-9x1233q6	21	14	activated	activate	VBN
cord-326228-9x1233q6	21	15	by	by	IN
cord-326228-9x1233q6	21	16	a	a	DT
cord-326228-9x1233q6	21	17	wide	wide	JJ
cord-326228-9x1233q6	21	18	range	range	NN
cord-326228-9x1233q6	21	19	of	of	IN
cord-326228-9x1233q6	21	20	PAMPs	pamp	NNS
cord-326228-9x1233q6	21	21	(	(	-LRB-
cord-326228-9x1233q6	21	22	bacterial	bacterial	JJ
cord-326228-9x1233q6	21	23	toxins	toxin	NNS
cord-326228-9x1233q6	21	24	,	,	,
cord-326228-9x1233q6	21	25	fungal	fungal	JJ
cord-326228-9x1233q6	21	26	and	and	CC
cord-326228-9x1233q6	21	27	viral	viral	JJ
cord-326228-9x1233q6	21	28	components	component	NNS
cord-326228-9x1233q6	21	29	)	)	-RRB-
cord-326228-9x1233q6	21	30	and	and	CC
cord-326228-9x1233q6	21	31	DAMPs	damp	NNS
cord-326228-9x1233q6	21	32	(	(	-LRB-
cord-326228-9x1233q6	21	33	e.g.	e.g.	RB
cord-326228-9x1233q6	21	34	extracellular	extracellular	JJ
cord-326228-9x1233q6	21	35	ATP	ATP	NNP
cord-326228-9x1233q6	21	36	,	,	,
cord-326228-9x1233q6	21	37	lysosomal	lysosomal	NN
cord-326228-9x1233q6	21	38	-	-	HYPH
cord-326228-9x1233q6	21	39	disrupting	disrupt	VBG
cord-326228-9x1233q6	21	40	crystals	crystal	NNS
cord-326228-9x1233q6	21	41	)	)	-RRB-
cord-326228-9x1233q6	21	42	,	,	,
cord-326228-9x1233q6	21	43	including	include	VBG
cord-326228-9x1233q6	21	44	those	those	DT
cord-326228-9x1233q6	21	45	of	of	IN
cord-326228-9x1233q6	21	46	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	21	47	origin	origin	NN
cord-326228-9x1233q6	21	48	.	.	.
cord-326228-9x1233q6	22	1	While	while	IN
cord-326228-9x1233q6	22	2	NLRP3	nlrp3	NN
cord-326228-9x1233q6	22	3	signalling	signalling	NN
cord-326228-9x1233q6	22	4	is	be	VBZ
cord-326228-9x1233q6	22	5	generally	generally	RB
cord-326228-9x1233q6	22	6	host	host	NN
cord-326228-9x1233q6	22	7	-	-	HYPH
cord-326228-9x1233q6	22	8	protective	protective	JJ
cord-326228-9x1233q6	22	9	,	,	,
cord-326228-9x1233q6	22	10	inappropriate	inappropriate	JJ
cord-326228-9x1233q6	22	11	or	or	CC
cord-326228-9x1233q6	22	12	sustained	sustain	VBD
cord-326228-9x1233q6	22	13	NLRP3	nlrp3	NN
cord-326228-9x1233q6	22	14	activation	activation	NN
cord-326228-9x1233q6	22	15	drives	drive	VBZ
cord-326228-9x1233q6	22	16	hereditary	hereditary	JJ
cord-326228-9x1233q6	22	17	autoinflammatory	autoinflammatory	NNP
cord-326228-9x1233q6	22	18	(	(	-LRB-
cord-326228-9x1233q6	22	19	e.g.	e.g.	RB
cord-326228-9x1233q6	22	20	cryopyrin	cryopyrin	NN
cord-326228-9x1233q6	22	21	-	-	HYPH
cord-326228-9x1233q6	22	22	associated	associate	VBN
cord-326228-9x1233q6	22	23	periodic	periodic	JJ
cord-326228-9x1233q6	22	24	syndromes	syndrome	NNS
cord-326228-9x1233q6	22	25	)	)	-RRB-
cord-326228-9x1233q6	22	26	and	and	CC
cord-326228-9x1233q6	22	27	acquired	acquire	VBD
cord-326228-9x1233q6	22	28	(	(	-LRB-
cord-326228-9x1233q6	22	29	e.g.	e.g.	DT
cord-326228-9x1233q6	22	30	gouty	gouty	JJ
cord-326228-9x1233q6	22	31	arthritis	arthritis	NN
cord-326228-9x1233q6	22	32	,	,	,
cord-326228-9x1233q6	22	33	Alzheimer	Alzheimer	NNP
cord-326228-9x1233q6	22	34	's	's	POS
cord-326228-9x1233q6	22	35	and	and	CC
cord-326228-9x1233q6	22	36	Parkinson	Parkinson	NNP
cord-326228-9x1233q6	22	37	's	's	POS
cord-326228-9x1233q6	22	38	diseases	disease	NNS
cord-326228-9x1233q6	22	39	)	)	-RRB-
cord-326228-9x1233q6	22	40	diseases	disease	NNS
cord-326228-9x1233q6	22	41	.	.	.
cord-326228-9x1233q6	23	1	3	3	CD
cord-326228-9x1233q6	23	2	Nod	nod	JJ
cord-326228-9x1233q6	23	3	-	-	HYPH
cord-326228-9x1233q6	23	4	like	like	JJ
cord-326228-9x1233q6	23	5	receptor	receptor	NN
cord-326228-9x1233q6	23	6	protein	protein	NN
cord-326228-9x1233q6	23	7	3	3	CD
cord-326228-9x1233q6	23	8	signals	signal	NNS
cord-326228-9x1233q6	23	9	by	by	IN
cord-326228-9x1233q6	23	10	forming	form	VBG
cord-326228-9x1233q6	23	11	a	a	DT
cord-326228-9x1233q6	23	12	caspase-1-activating	caspase-1-activate	VBG
cord-326228-9x1233q6	23	13	complex	complex	NN
cord-326228-9x1233q6	23	14	called	call	VBN
cord-326228-9x1233q6	23	15	the	the	DT
cord-326228-9x1233q6	23	16	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	23	17	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	23	18	.	.	.
cord-326228-9x1233q6	24	1	Upon	upon	IN
cord-326228-9x1233q6	24	2	activation	activation	NN
cord-326228-9x1233q6	24	3	,	,	,
cord-326228-9x1233q6	24	4	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	24	5	selfassociates	selfassociate	NNS
cord-326228-9x1233q6	24	6	and	and	CC
cord-326228-9x1233q6	24	7	engages	engage	VBZ
cord-326228-9x1233q6	24	8	with	with	IN
cord-326228-9x1233q6	24	9	the	the	DT
cord-326228-9x1233q6	24	10	signal	signal	NN
cord-326228-9x1233q6	24	11	adaptor	adaptor	NN
cord-326228-9x1233q6	24	12	,	,	,
cord-326228-9x1233q6	24	13	ASC	ASC	NNP
cord-326228-9x1233q6	24	14	(	(	-LRB-
cord-326228-9x1233q6	24	15	apoptosis	apoptosis	NN
cord-326228-9x1233q6	24	16	-	-	HYPH
cord-326228-9x1233q6	24	17	associated	associate	VBN
cord-326228-9x1233q6	24	18	speck	speck	NN
cord-326228-9x1233q6	24	19	-	-	HYPH
cord-326228-9x1233q6	24	20	like	like	JJ
cord-326228-9x1233q6	24	21	protein	protein	NN
cord-326228-9x1233q6	24	22	containing	contain	VBG
cord-326228-9x1233q6	24	23	a	a	DT
cord-326228-9x1233q6	24	24	CARD	card	NN
cord-326228-9x1233q6	24	25	)	)	-RRB-
cord-326228-9x1233q6	24	26	,	,	,
cord-326228-9x1233q6	24	27	which	which	WDT
cord-326228-9x1233q6	24	28	then	then	RB
cord-326228-9x1233q6	24	29	interacts	interact	VBZ
cord-326228-9x1233q6	24	30	with	with	IN
cord-326228-9x1233q6	24	31	caspase-1	caspase-1	NNP
cord-326228-9x1233q6	24	32	to	to	TO
cord-326228-9x1233q6	24	33	form	form	VB
cord-326228-9x1233q6	24	34	the	the	DT
cord-326228-9x1233q6	24	35	inflammasome	inflammasome	NN
cord-326228-9x1233q6	24	36	.	.	.
cord-326228-9x1233q6	25	1	4	4	LS
cord-326228-9x1233q6	25	2	Active	Active	NNP
cord-326228-9x1233q6	25	3	caspase-1	caspase-1	NNP
cord-326228-9x1233q6	25	4	then	then	RB
cord-326228-9x1233q6	25	5	cleaves	cleave	VBZ
cord-326228-9x1233q6	25	6	various	various	JJ
cord-326228-9x1233q6	25	7	substrates	substrate	NNS
cord-326228-9x1233q6	25	8	to	to	TO
cord-326228-9x1233q6	25	9	induce	induce	VB
cord-326228-9x1233q6	25	10	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	25	11	signalling	signalling	NN
cord-326228-9x1233q6	25	12	,	,	,
cord-326228-9x1233q6	25	13	including	include	VBG
cord-326228-9x1233q6	25	14	the	the	DT
cord-326228-9x1233q6	25	15	cytokines	cytokine	NNS
cord-326228-9x1233q6	25	16	IL-1b	IL-1b	NNS
cord-326228-9x1233q6	25	17	and	and	CC
cord-326228-9x1233q6	25	18	IL-18	IL-18	NNP
cord-326228-9x1233q6	25	19	,	,	,
cord-326228-9x1233q6	25	20	and	and	CC
cord-326228-9x1233q6	25	21	the	the	DT
cord-326228-9x1233q6	25	22	cell	cell	NN
cord-326228-9x1233q6	25	23	executioner	executioner	NN
cord-326228-9x1233q6	25	24	gasdermin	gasdermin	NNP
cord-326228-9x1233q6	25	25	D	D	NNP
cord-326228-9x1233q6	25	26	(	(	-LRB-
cord-326228-9x1233q6	25	27	GSDMD	GSDMD	NNP
cord-326228-9x1233q6	25	28	)	)	-RRB-
cord-326228-9x1233q6	25	29	,	,	,
cord-326228-9x1233q6	25	30	which	which	WDT
cord-326228-9x1233q6	25	31	induces	induce	VBZ
cord-326228-9x1233q6	25	32	a	a	DT
cord-326228-9x1233q6	25	33	lytic	lytic	JJ
cord-326228-9x1233q6	25	34	form	form	NN
cord-326228-9x1233q6	25	35	of	of	IN
cord-326228-9x1233q6	25	36	cell	cell	NN
cord-326228-9x1233q6	25	37	death	death	NN
cord-326228-9x1233q6	25	38	called	call	VBN
cord-326228-9x1233q6	25	39	pyroptosis	pyroptosis	NNP
cord-326228-9x1233q6	25	40	.	.	.
cord-326228-9x1233q6	26	1	5	5	LS
cord-326228-9x1233q6	27	1	The	the	DT
cord-326228-9x1233q6	27	2	subcellular	subcellular	JJ
cord-326228-9x1233q6	27	3	location	location	NN
cord-326228-9x1233q6	27	4	of	of	IN
cord-326228-9x1233q6	27	5	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	27	6	activation	activation	NN
cord-326228-9x1233q6	27	7	remains	remain	VBZ
cord-326228-9x1233q6	27	8	controversial	controversial	JJ
cord-326228-9x1233q6	27	9	,	,	,
cord-326228-9x1233q6	27	10	with	with	IN
cord-326228-9x1233q6	27	11	various	various	JJ
cord-326228-9x1233q6	27	12	reports	report	NNS
cord-326228-9x1233q6	27	13	locating	locate	VBG
cord-326228-9x1233q6	27	14	active	active	JJ
cord-326228-9x1233q6	27	15	NLRP3	nlrp3	XX
cord-326228-9x1233q6	27	16	at	at	IN
cord-326228-9x1233q6	27	17	cytosolic	cytosolic	JJ
cord-326228-9x1233q6	27	18	face	face	NN
cord-326228-9x1233q6	27	19	of	of	IN
cord-326228-9x1233q6	27	20	the	the	DT
cord-326228-9x1233q6	27	21	outer	outer	JJ
cord-326228-9x1233q6	27	22	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	27	23	membrane	membrane	NN
cord-326228-9x1233q6	27	24	,	,	,
cord-326228-9x1233q6	27	25	the	the	DT
cord-326228-9x1233q6	27	26	attachment	attachment	NN
cord-326228-9x1233q6	27	27	points	point	VBZ
cord-326228-9x1233q6	27	28	between	between	IN
cord-326228-9x1233q6	27	29	the	the	DT
cord-326228-9x1233q6	27	30	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	27	31	and	and	CC
cord-326228-9x1233q6	27	32	ER	ER	NNP
cord-326228-9x1233q6	27	33	,	,	,
cord-326228-9x1233q6	27	34	6	6	CD
cord-326228-9x1233q6	27	35	or	or	CC
cord-326228-9x1233q6	27	36	the	the	DT
cord-326228-9x1233q6	27	37	dispersed	disperse	VBN
cord-326228-9x1233q6	27	38	trans	trans	NNP
cord-326228-9x1233q6	27	39	-	-	NNP
cord-326228-9x1233q6	27	40	Golgi	Golgi	NNP
cord-326228-9x1233q6	27	41	network	network	NN
cord-326228-9x1233q6	27	42	.	.	.
cord-326228-9x1233q6	28	1	7	7	CD
cord-326228-9x1233q6	29	1	In	in	IN
cord-326228-9x1233q6	29	2	murine	murine	NN
cord-326228-9x1233q6	29	3	in	in	FW
cord-326228-9x1233q6	29	4	vitro	vitro	FW
cord-326228-9x1233q6	29	5	systems	system	NNS
cord-326228-9x1233q6	29	6	,	,	.
cord-326228-9x1233q6	30	1	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	30	2	activation	activation	NN
cord-326228-9x1233q6	30	3	generally	generally	RB
cord-326228-9x1233q6	30	4	follows	follow	VBZ
cord-326228-9x1233q6	30	5	a	a	DT
cord-326228-9x1233q6	30	6	2-step	2-step	CD
cord-326228-9x1233q6	30	7	model	model	NN
cord-326228-9x1233q6	30	8	.	.	.
cord-326228-9x1233q6	31	1	8	8	CD
cord-326228-9x1233q6	31	2	Signal	Signal	NNP
cord-326228-9x1233q6	31	3	1	1	CD
cord-326228-9x1233q6	31	4	is	be	VBZ
cord-326228-9x1233q6	31	5	usually	usually	RB
cord-326228-9x1233q6	31	6	a	a	DT
cord-326228-9x1233q6	31	7	Toll	toll	NN
cord-326228-9x1233q6	31	8	-	-	HYPH
cord-326228-9x1233q6	31	9	like	like	JJ
cord-326228-9x1233q6	31	10	receptor	receptor	NN
cord-326228-9x1233q6	31	11	(	(	-LRB-
cord-326228-9x1233q6	31	12	TLR	TLR	NNP
cord-326228-9x1233q6	31	13	)	)	-RRB-
cord-326228-9x1233q6	31	14	agonist	agonist	NN
cord-326228-9x1233q6	31	15	.	.	.
cord-326228-9x1233q6	32	1	Signal	signal	NN
cord-326228-9x1233q6	32	2	1	1	CD
cord-326228-9x1233q6	32	3	activates	activate	VBZ
cord-326228-9x1233q6	32	4	the	the	DT
cord-326228-9x1233q6	32	5	nuclear	nuclear	JJ
cord-326228-9x1233q6	32	6	factor	factor	NN
cord-326228-9x1233q6	32	7	jlight	jlight	NN
cord-326228-9x1233q6	32	8	-	-	HYPH
cord-326228-9x1233q6	32	9	chain	chain	NN
cord-326228-9x1233q6	32	10	-	-	HYPH
cord-326228-9x1233q6	32	11	enhancer	enhancer	NN
cord-326228-9x1233q6	32	12	of	of	IN
cord-326228-9x1233q6	32	13	activated	activate	VBN
cord-326228-9x1233q6	32	14	B	b	NN
cord-326228-9x1233q6	32	15	cells	cell	NNS
cord-326228-9x1233q6	32	16	(	(	-LRB-
cord-326228-9x1233q6	32	17	NF	nf	NN
cord-326228-9x1233q6	32	18	-	-	HYPH
cord-326228-9x1233q6	32	19	jB	jb	NN
cord-326228-9x1233q6	32	20	)	)	-RRB-
cord-326228-9x1233q6	33	1	pathway	pathway	NNP
cord-326228-9x1233q6	33	2	to	to	TO
cord-326228-9x1233q6	33	3	transcriptionally	transcriptionally	RB
cord-326228-9x1233q6	33	4	upregulate	upregulate	VB
cord-326228-9x1233q6	33	5	NLRP3	nlrp3	XX
cord-326228-9x1233q6	34	1	and	and	CC
cord-326228-9x1233q6	34	2	pro	pro	JJ
cord-326228-9x1233q6	34	3	-	-	NNS
cord-326228-9x1233q6	34	4	IL-1b	il-1b	JJ
cord-326228-9x1233q6	35	1	,	,	,
cord-326228-9x1233q6	35	2	and	and	CC
cord-326228-9x1233q6	35	3	induce	induce	VB
cord-326228-9x1233q6	35	4	NLRP3	nlrp3	NN
cord-326228-9x1233q6	35	5	posttranslational	posttranslational	JJ
cord-326228-9x1233q6	35	6	modifications	modification	NNS
cord-326228-9x1233q6	35	7	that	that	WDT
cord-326228-9x1233q6	35	8	poise	poise	VBP
cord-326228-9x1233q6	35	9	NLRP3	nlrp3	NN
cord-326228-9x1233q6	35	10	for	for	IN
cord-326228-9x1233q6	35	11	signalling	signal	VBG
cord-326228-9x1233q6	35	12	.	.	.
cord-326228-9x1233q6	36	1	A	a	DT
cord-326228-9x1233q6	36	2	plethora	plethora	NN
cord-326228-9x1233q6	36	3	of	of	IN
cord-326228-9x1233q6	36	4	PAMPs	pamp	NNS
cord-326228-9x1233q6	36	5	and	and	CC
cord-326228-9x1233q6	36	6	DAMPs	damp	NNS
cord-326228-9x1233q6	36	7	can	can	MD
cord-326228-9x1233q6	36	8	provide	provide	VB
cord-326228-9x1233q6	36	9	the	the	DT
cord-326228-9x1233q6	36	10	2nd	2nd	JJ
cord-326228-9x1233q6	36	11	signal	signal	NN
cord-326228-9x1233q6	36	12	,	,	,
cord-326228-9x1233q6	36	13	which	which	WDT
cord-326228-9x1233q6	36	14	is	be	VBZ
cord-326228-9x1233q6	36	15	the	the	DT
cord-326228-9x1233q6	36	16	'	'	``
cord-326228-9x1233q6	36	17	trigger	trigger	NN
cord-326228-9x1233q6	36	18	'	'	''
cord-326228-9x1233q6	36	19	for	for	IN
cord-326228-9x1233q6	36	20	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	36	21	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	36	22	assembly	assembly	NNP
cord-326228-9x1233q6	36	23	.	.	.
cord-326228-9x1233q6	37	1	These	these	DT
cord-326228-9x1233q6	37	2	PAMPs	pamp	NNS
cord-326228-9x1233q6	37	3	and	and	CC
cord-326228-9x1233q6	37	4	DAMPs	damp	NNS
cord-326228-9x1233q6	37	5	induce	induce	VBP
cord-326228-9x1233q6	37	6	one	one	CD
cord-326228-9x1233q6	37	7	or	or	CC
cord-326228-9x1233q6	37	8	more	more	JJR
cord-326228-9x1233q6	37	9	key	key	JJ
cord-326228-9x1233q6	37	10	features	feature	NNS
cord-326228-9x1233q6	37	11	of	of	IN
cord-326228-9x1233q6	37	12	disrupted	disrupt	VBN
cord-326228-9x1233q6	37	13	cytosolic	cytosolic	JJ
cord-326228-9x1233q6	37	14	homoeostasis	homoeostasis	NN
cord-326228-9x1233q6	37	15	-K	-K	.
cord-326228-9x1233q6	38	1	+	+	CC
cord-326228-9x1233q6	38	2	efflux	efflux	NN
cord-326228-9x1233q6	38	3	,	,	,
cord-326228-9x1233q6	38	4	lysosomal	lysosomal	JJ
cord-326228-9x1233q6	38	5	rupture	rupture	NN
cord-326228-9x1233q6	38	6	or	or	CC
cord-326228-9x1233q6	38	7	the	the	DT
cord-326228-9x1233q6	38	8	production	production	NN
cord-326228-9x1233q6	38	9	of	of	IN
cord-326228-9x1233q6	38	10	reactive	reactive	JJ
cord-326228-9x1233q6	38	11	oxygen	oxygen	NN
cord-326228-9x1233q6	38	12	species	specie	NNS
cord-326228-9x1233q6	39	1	(	(	-LRB-
cord-326228-9x1233q6	39	2	ROS)to	ros)to	CD
cord-326228-9x1233q6	39	3	induce	induce	NN
cord-326228-9x1233q6	39	4	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	39	5	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	39	6	assembly	assembly	NN
cord-326228-9x1233q6	39	7	and	and	CC
cord-326228-9x1233q6	39	8	signalling	signalling	NN
cord-326228-9x1233q6	39	9	.	.	.
cord-326228-9x1233q6	40	1	While	while	IN
cord-326228-9x1233q6	40	2	there	there	EX
cord-326228-9x1233q6	40	3	is	be	VBZ
cord-326228-9x1233q6	40	4	currently	currently	RB
cord-326228-9x1233q6	40	5	no	no	DT
cord-326228-9x1233q6	40	6	universal	universal	JJ
cord-326228-9x1233q6	40	7	or	or	CC
cord-326228-9x1233q6	40	8	unifying	unifying	JJ
cord-326228-9x1233q6	40	9	activation	activation	NN
cord-326228-9x1233q6	40	10	model	model	NN
cord-326228-9x1233q6	40	11	for	for	IN
cord-326228-9x1233q6	40	12	the	the	DT
cord-326228-9x1233q6	40	13	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	40	14	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	40	15	,	,	,
cord-326228-9x1233q6	40	16	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	40	17	is	be	VBZ
cord-326228-9x1233q6	40	18	a	a	DT
cord-326228-9x1233q6	40	19	sensor	sensor	NN
cord-326228-9x1233q6	40	20	for	for	IN
cord-326228-9x1233q6	40	21	disrupted	disrupt	VBN
cord-326228-9x1233q6	40	22	homoeostasis	homoeostasis	NN
cord-326228-9x1233q6	40	23	,	,	,
cord-326228-9x1233q6	40	24	including	include	VBG
cord-326228-9x1233q6	40	25	perturbed	perturb	VBN
cord-326228-9x1233q6	40	26	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	40	27	function	function	NN
cord-326228-9x1233q6	40	28	.	.	.
cord-326228-9x1233q6	41	1	For	for	IN
cord-326228-9x1233q6	41	2	example	example	NN
cord-326228-9x1233q6	41	3	,	,	,
cord-326228-9x1233q6	41	4	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	41	5	dysfunction	dysfunction	NN
cord-326228-9x1233q6	41	6	triggers	trigger	VBZ
cord-326228-9x1233q6	41	7	the	the	DT
cord-326228-9x1233q6	41	8	generation	generation	NN
cord-326228-9x1233q6	41	9	of	of	IN
cord-326228-9x1233q6	41	10	ROS	ROS	NNP
cord-326228-9x1233q6	41	11	(	(	-LRB-
cord-326228-9x1233q6	41	12	mitoROS	mitoROS	NNP
cord-326228-9x1233q6	41	13	)	)	-RRB-
cord-326228-9x1233q6	41	14	,	,	,
cord-326228-9x1233q6	41	15	which	which	WDT
cord-326228-9x1233q6	41	16	can	can	MD
cord-326228-9x1233q6	41	17	elicit	elicit	VB
cord-326228-9x1233q6	41	18	a	a	DT
cord-326228-9x1233q6	41	19	K	k	NN
cord-326228-9x1233q6	41	20	+	+	CC
cord-326228-9x1233q6	41	21	-independent	-independent	JJ
cord-326228-9x1233q6	41	22	NLRP3	nlrp3	XX
cord-326228-9x1233q6	41	23	activation	activation	NN
cord-326228-9x1233q6	41	24	pathway	pathway	NN
cord-326228-9x1233q6	41	25	.	.	.
cord-326228-9x1233q6	42	1	9	9	CD
cord-326228-9x1233q6	43	1	The	the	DT
cord-326228-9x1233q6	43	2	TLR7	TLR7	NNP
cord-326228-9x1233q6	43	3	agonist	agonist	NN
cord-326228-9x1233q6	43	4	imiquimod	imiquimod	NN
cord-326228-9x1233q6	43	5	(	(	-LRB-
cord-326228-9x1233q6	43	6	R837	R837	NNP
cord-326228-9x1233q6	43	7	)	)	-RRB-
cord-326228-9x1233q6	43	8	and	and	CC
cord-326228-9x1233q6	43	9	the	the	DT
cord-326228-9x1233q6	43	10	related	related	JJ
cord-326228-9x1233q6	43	11	molecule	molecule	NN
cord-326228-9x1233q6	44	1	CL097	cl097	NN
cord-326228-9x1233q6	44	2	inhibit	inhibit	VB
cord-326228-9x1233q6	44	3	the	the	DT
cord-326228-9x1233q6	44	4	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	44	5	quinone	quinone	NN
cord-326228-9x1233q6	44	6	oxidoreductase	oxidoreductase	NN
cord-326228-9x1233q6	44	7	NQO2	NQO2	NNP
cord-326228-9x1233q6	45	1	(	(	-LRB-
cord-326228-9x1233q6	45	2	Nribosyldihydronicotinamide	nribosyldihydronicotinamide	NN
cord-326228-9x1233q6	45	3	:	:	:
cord-326228-9x1233q6	45	4	quinone	quinone	NN
cord-326228-9x1233q6	45	5	reductase	reductase	NNP
cord-326228-9x1233q6	45	6	2	2	CD
cord-326228-9x1233q6	45	7	)	)	-RRB-
cord-326228-9x1233q6	45	8	and	and	CC
cord-326228-9x1233q6	45	9	complex	complex	JJ
cord-326228-9x1233q6	45	10	I.	i.	NN
cord-326228-9x1233q6	46	1	In	in	IN
cord-326228-9x1233q6	46	2	dysregulating	dysregulate	VBG
cord-326228-9x1233q6	46	3	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	46	4	respiration	respiration	NN
cord-326228-9x1233q6	46	5	,	,	,
cord-326228-9x1233q6	46	6	these	these	DT
cord-326228-9x1233q6	46	7	compounds	compound	NNS
cord-326228-9x1233q6	46	8	trigger	trigger	VBP
cord-326228-9x1233q6	46	9	the	the	DT
cord-326228-9x1233q6	46	10	production	production	NN
cord-326228-9x1233q6	46	11	of	of	IN
cord-326228-9x1233q6	46	12	mitoROS	mitoROS	NNP
cord-326228-9x1233q6	46	13	,	,	,
cord-326228-9x1233q6	46	14	and	and	CC
cord-326228-9x1233q6	46	15	resultant	resultant	JJ
cord-326228-9x1233q6	46	16	NLRP3	nlrp3	XX
cord-326228-9x1233q6	46	17	inflammasome	inflammasome	NN
cord-326228-9x1233q6	46	18	signalling	signalling	NN
cord-326228-9x1233q6	46	19	.	.	.
cord-326228-9x1233q6	47	1	9	9	CD
cord-326228-9x1233q6	48	1	Apoptotic	Apoptotic	NNP
cord-326228-9x1233q6	48	2	Bcl-2associated	bcl-2associated	CD
cord-326228-9x1233q6	49	1	X	x	NN
cord-326228-9x1233q6	49	2	protein	protein	NN
cord-326228-9x1233q6	49	3	(	(	-LRB-
cord-326228-9x1233q6	49	4	BAX)/Bcl-2	BAX)/Bcl-2	NNP
cord-326228-9x1233q6	49	5	homologous	homologous	JJ
cord-326228-9x1233q6	49	6	killer	killer	NN
cord-326228-9x1233q6	49	7	(	(	-LRB-
cord-326228-9x1233q6	49	8	BAK	BAK	NNP
cord-326228-9x1233q6	49	9	)	)	-RRB-
cord-326228-9x1233q6	49	10	pores	pore	VBZ
cord-326228-9x1233q6	49	11	on	on	IN
cord-326228-9x1233q6	49	12	the	the	DT
cord-326228-9x1233q6	49	13	outer	outer	JJ
cord-326228-9x1233q6	49	14	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	49	15	membrane	membrane	NN
cord-326228-9x1233q6	49	16	also	also	RB
cord-326228-9x1233q6	49	17	trigger	trigger	VBP
cord-326228-9x1233q6	49	18	caspase-3/7-dependent	caspase-3/7-dependent	NNP
cord-326228-9x1233q6	49	19	NLRP3	nlrp3	NN
cord-326228-9x1233q6	49	20	activation	activation	NN
cord-326228-9x1233q6	49	21	.	.	.
cord-326228-9x1233q6	50	1	10	10	CD
cord-326228-9x1233q6	51	1	The	the	DT
cord-326228-9x1233q6	51	2	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	51	3	antiviral	antiviral	JJ
cord-326228-9x1233q6	51	4	signalling	signal	VBG
cord-326228-9x1233q6	51	5	protein	protein	NN
cord-326228-9x1233q6	51	6	(	(	-LRB-
cord-326228-9x1233q6	51	7	MAVS	MAVS	NNP
cord-326228-9x1233q6	51	8	)	)	-RRB-
cord-326228-9x1233q6	51	9	may	may	MD
cord-326228-9x1233q6	51	10	also	also	RB
cord-326228-9x1233q6	51	11	promote	promote	VB
cord-326228-9x1233q6	51	12	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	51	13	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	51	14	assembly	assembly	NN
cord-326228-9x1233q6	51	15	by	by	IN
cord-326228-9x1233q6	51	16	directly	directly	RB
cord-326228-9x1233q6	51	17	recruiting	recruit	VBG
cord-326228-9x1233q6	51	18	NLRP3	nlrp3	XX
cord-326228-9x1233q6	51	19	to	to	IN
cord-326228-9x1233q6	51	20	the	the	DT
cord-326228-9x1233q6	51	21	outer	outer	JJ
cord-326228-9x1233q6	51	22	membrane	membrane	NN
cord-326228-9x1233q6	51	23	.	.	.
cord-326228-9x1233q6	52	1	11	11	CD
cord-326228-9x1233q6	52	2	Recognition	recognition	NN
cord-326228-9x1233q6	52	3	of	of	IN
cord-326228-9x1233q6	52	4	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	52	5	molecules	molecule	NNS
cord-326228-9x1233q6	52	6	by	by	IN
cord-326228-9x1233q6	52	7	host	host	NN
cord-326228-9x1233q6	52	8	PRRs	PRRs	NNP
cord-326228-9x1233q6	52	9	is	be	VBZ
cord-326228-9x1233q6	52	10	a	a	DT
cord-326228-9x1233q6	52	11	nascent	nascent	JJ
cord-326228-9x1233q6	52	12	field	field	NN
cord-326228-9x1233q6	52	13	with	with	IN
cord-326228-9x1233q6	52	14	emerging	emerge	VBG
cord-326228-9x1233q6	52	15	relevance	relevance	NN
cord-326228-9x1233q6	52	16	to	to	IN
cord-326228-9x1233q6	52	17	inflammasome	inflammasome	NN
cord-326228-9x1233q6	52	18	biology	biology	NN
cord-326228-9x1233q6	52	19	and	and	CC
cord-326228-9x1233q6	52	20	disease	disease	NN
cord-326228-9x1233q6	52	21	.	.	.
cord-326228-9x1233q6	53	1	When	when	WRB
cord-326228-9x1233q6	53	2	translocated	translocate	VBN
cord-326228-9x1233q6	53	3	to	to	IN
cord-326228-9x1233q6	53	4	the	the	DT
cord-326228-9x1233q6	53	5	cytosol	cytosol	NN
cord-326228-9x1233q6	53	6	during	during	IN
cord-326228-9x1233q6	53	7	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	53	8	damage	damage	NN
cord-326228-9x1233q6	53	9	,	,	,
cord-326228-9x1233q6	53	10	several	several	JJ
cord-326228-9x1233q6	53	11	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	53	12	components	component	NNS
cord-326228-9x1233q6	53	13	are	be	VBP
cord-326228-9x1233q6	53	14	reported	report	VBN
cord-326228-9x1233q6	53	15	to	to	TO
cord-326228-9x1233q6	53	16	trigger	trigger	VB
cord-326228-9x1233q6	53	17	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	53	18	activation	activation	NN
cord-326228-9x1233q6	53	19	,	,	,
cord-326228-9x1233q6	53	20	including	include	VBG
cord-326228-9x1233q6	53	21	cardiolipin	cardiolipin	NNP
cord-326228-9x1233q6	53	22	and	and	CC
cord-326228-9x1233q6	53	23	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	53	24	,	,	,
cord-326228-9x1233q6	53	25	[	[	-LRB-
cord-326228-9x1233q6	53	26	12	12	CD
cord-326228-9x1233q6	53	27	]	]	-RRB-
cord-326228-9x1233q6	54	1	[	[	-LRB-
cord-326228-9x1233q6	54	2	13	13	CD
cord-326228-9x1233q6	54	3	]	]	-RRB-
cord-326228-9x1233q6	54	4	[	[	-LRB-
cord-326228-9x1233q6	54	5	14	14	CD
cord-326228-9x1233q6	54	6	]	]	-RRB-
cord-326228-9x1233q6	55	1	[	[	-LRB-
cord-326228-9x1233q6	55	2	15	15	CD
cord-326228-9x1233q6	55	3	]	]	-RRB-
cord-326228-9x1233q6	55	4	although	although	IN
cord-326228-9x1233q6	55	5	these	these	DT
cord-326228-9x1233q6	55	6	remain	remain	VBP
cord-326228-9x1233q6	55	7	controversial	controversial	JJ
cord-326228-9x1233q6	55	8	.	.	.
cord-326228-9x1233q6	56	1	Mechanistically	Mechanistically	NNP
cord-326228-9x1233q6	56	2	,	,	,
cord-326228-9x1233q6	56	3	it	-PRON-	PRP
cord-326228-9x1233q6	56	4	is	be	VBZ
cord-326228-9x1233q6	56	5	unclear	unclear	JJ
cord-326228-9x1233q6	56	6	how	how	WRB
cord-326228-9x1233q6	56	7	these	these	DT
cord-326228-9x1233q6	56	8	components	component	NNS
cord-326228-9x1233q6	56	9	may	may	MD
cord-326228-9x1233q6	56	10	become	become	VB
cord-326228-9x1233q6	56	11	liberated	liberated	JJ
cord-326228-9x1233q6	56	12	from	from	IN
cord-326228-9x1233q6	56	13	the	the	DT
cord-326228-9x1233q6	56	14	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	56	15	inner	inner	JJ
cord-326228-9x1233q6	56	16	membrane	membrane	NN
cord-326228-9x1233q6	56	17	(	(	-LRB-
cord-326228-9x1233q6	56	18	cardiolipin	cardiolipin	NNP
cord-326228-9x1233q6	56	19	)	)	-RRB-
cord-326228-9x1233q6	56	20	or	or	CC
cord-326228-9x1233q6	56	21	matrix	matrix	NNP
cord-326228-9x1233q6	56	22	(	(	-LRB-
cord-326228-9x1233q6	56	23	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	56	24	)	)	-RRB-
cord-326228-9x1233q6	56	25	for	for	IN
cord-326228-9x1233q6	56	26	participation	participation	NN
cord-326228-9x1233q6	56	27	in	in	IN
cord-326228-9x1233q6	56	28	NLRP3	nlrp3	NN
cord-326228-9x1233q6	56	29	signalling	signal	VBG
cord-326228-9x1233q6	56	30	in	in	IN
cord-326228-9x1233q6	56	31	the	the	DT
cord-326228-9x1233q6	56	32	cytosol	cytosol	NN
cord-326228-9x1233q6	56	33	.	.	.
cord-326228-9x1233q6	57	1	Mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	57	2	network	network	NN
cord-326228-9x1233q6	57	3	dynamics	dynamic	NNS
cord-326228-9x1233q6	57	4	,	,	,
cord-326228-9x1233q6	57	5	metabolic	metabolic	JJ
cord-326228-9x1233q6	57	6	state	state	NN
cord-326228-9x1233q6	57	7	and	and	CC
cord-326228-9x1233q6	57	8	mitoROS	mitoROS	NNP
cord-326228-9x1233q6	57	9	can	can	MD
cord-326228-9x1233q6	57	10	all	all	DT
cord-326228-9x1233q6	57	11	influence	influence	VB
cord-326228-9x1233q6	57	12	NLRP3	nlrp3	NN
cord-326228-9x1233q6	57	13	activation	activation	NN
cord-326228-9x1233q6	57	14	and	and	CC
cord-326228-9x1233q6	57	15	the	the	DT
cord-326228-9x1233q6	57	16	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	57	17	signalling	signal	VBG
cord-326228-9x1233q6	57	18	capacity	capacity	NN
cord-326228-9x1233q6	57	19	of	of	IN
cord-326228-9x1233q6	57	20	a	a	DT
cord-326228-9x1233q6	57	21	cell	cell	NN
cord-326228-9x1233q6	57	22	.	.	.
cord-326228-9x1233q6	58	1	It	-PRON-	PRP
cord-326228-9x1233q6	58	2	is	be	VBZ
cord-326228-9x1233q6	58	3	thus	thus	RB
cord-326228-9x1233q6	58	4	possible	possible	JJ
cord-326228-9x1233q6	58	5	that	that	IN
cord-326228-9x1233q6	58	6	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	58	7	,	,	,
cord-326228-9x1233q6	58	8	mitoROS	mitoROS	NNP
cord-326228-9x1233q6	58	9	or	or	CC
cord-326228-9x1233q6	58	10	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	58	11	promote	promote	VBP
cord-326228-9x1233q6	58	12	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	58	13	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	58	14	assembly	assembly	NN
cord-326228-9x1233q6	58	15	and	and	CC
cord-326228-9x1233q6	58	16	cytokine	cytokine	NN
cord-326228-9x1233q6	58	17	processing	processing	NN
cord-326228-9x1233q6	58	18	through	through	IN
cord-326228-9x1233q6	58	19	an	an	DT
cord-326228-9x1233q6	58	20	indirect	indirect	JJ
cord-326228-9x1233q6	58	21	mechanism	mechanism	NN
cord-326228-9x1233q6	58	22	.	.	.
cord-326228-9x1233q6	59	1	As	as	IN
cord-326228-9x1233q6	59	2	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	59	3	may	may	MD
cord-326228-9x1233q6	59	4	stimulate	stimulate	VB
cord-326228-9x1233q6	59	5	NLRP3	nlrp3	NN
cord-326228-9x1233q6	59	6	activity	activity	NN
cord-326228-9x1233q6	59	7	through	through	IN
cord-326228-9x1233q6	59	8	mechanisms	mechanism	NNS
cord-326228-9x1233q6	59	9	other	other	JJ
cord-326228-9x1233q6	59	10	than	than	IN
cord-326228-9x1233q6	59	11	membrane	membrane	NN
cord-326228-9x1233q6	59	12	rupture	rupture	NN
cord-326228-9x1233q6	59	13	and	and	CC
cord-326228-9x1233q6	59	14	release	release	NN
cord-326228-9x1233q6	59	15	of	of	IN
cord-326228-9x1233q6	59	16	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	59	17	components	component	NNS
cord-326228-9x1233q6	59	18	,	,	,
cord-326228-9x1233q6	59	19	it	-PRON-	PRP
cord-326228-9x1233q6	59	20	is	be	VBZ
cord-326228-9x1233q6	59	21	important	important	JJ
cord-326228-9x1233q6	59	22	to	to	TO
cord-326228-9x1233q6	59	23	consider	consider	VB
cord-326228-9x1233q6	59	24	the	the	DT
cord-326228-9x1233q6	59	25	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	59	26	network	network	NN
cord-326228-9x1233q6	59	27	holistically	holistically	RB
cord-326228-9x1233q6	59	28	,	,	,
cord-326228-9x1233q6	59	29	as	as	IN
cord-326228-9x1233q6	59	30	a	a	DT
cord-326228-9x1233q6	59	31	complex	complex	JJ
cord-326228-9x1233q6	59	32	and	and	CC
cord-326228-9x1233q6	59	33	dynamic	dynamic	JJ
cord-326228-9x1233q6	59	34	organelle	organelle	NN
cord-326228-9x1233q6	59	35	.	.	.
cord-326228-9x1233q6	60	1	Aside	aside	RB
cord-326228-9x1233q6	60	2	from	from	IN
cord-326228-9x1233q6	60	3	NLRP3	nlrp3	XX
cord-326228-9x1233q6	60	4	,	,	,
cord-326228-9x1233q6	60	5	other	other	JJ
cord-326228-9x1233q6	60	6	PRRs	prr	NNS
cord-326228-9x1233q6	60	7	sense	sense	NN
cord-326228-9x1233q6	60	8	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	60	9	molecules	molecule	NNS
cord-326228-9x1233q6	60	10	to	to	TO
cord-326228-9x1233q6	60	11	induce	induce	VB
cord-326228-9x1233q6	60	12	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	60	13	signalling	signalling	NN
cord-326228-9x1233q6	60	14	,	,	,
cord-326228-9x1233q6	60	15	amongst	amongst	IN
cord-326228-9x1233q6	60	16	which	which	WDT
cord-326228-9x1233q6	60	17	TLR9	TLR9	NNP
cord-326228-9x1233q6	60	18	,	,	,
cord-326228-9x1233q6	60	19	AIM2	AIM2	NNP
cord-326228-9x1233q6	60	20	and	and	CC
cord-326228-9x1233q6	60	21	cGAS	cgas	NN
cord-326228-9x1233q6	60	22	will	will	MD
cord-326228-9x1233q6	60	23	be	be	VB
cord-326228-9x1233q6	60	24	discussed	discuss	VBN
cord-326228-9x1233q6	60	25	herein	herein	RB
cord-326228-9x1233q6	60	26	.	.	.
cord-326228-9x1233q6	61	1	Here	here	RB
cord-326228-9x1233q6	61	2	,	,	,
cord-326228-9x1233q6	61	3	we	-PRON-	PRP
cord-326228-9x1233q6	61	4	review	review	VBP
cord-326228-9x1233q6	61	5	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	61	6	functions	function	NNS
cord-326228-9x1233q6	61	7	in	in	IN
cord-326228-9x1233q6	61	8	innate	innate	JJ
cord-326228-9x1233q6	61	9	immunity	immunity	NN
cord-326228-9x1233q6	61	10	and	and	CC
cord-326228-9x1233q6	61	11	speculate	speculate	VB
cord-326228-9x1233q6	61	12	how	how	WRB
cord-326228-9x1233q6	61	13	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	61	14	may	may	MD
cord-326228-9x1233q6	61	15	influence	influence	VB
cord-326228-9x1233q6	61	16	PRR	PRR	NNP
cord-326228-9x1233q6	61	17	activity	activity	NN
cord-326228-9x1233q6	61	18	during	during	IN
cord-326228-9x1233q6	61	19	infection	infection	NN
cord-326228-9x1233q6	61	20	and	and	CC
cord-326228-9x1233q6	61	21	disease	disease	NN
cord-326228-9x1233q6	61	22	.	.	.
cord-326228-9x1233q6	62	1	The	the	DT
cord-326228-9x1233q6	62	2	mechanisms	mechanism	NNS
cord-326228-9x1233q6	62	3	by	by	IN
cord-326228-9x1233q6	62	4	which	which	WDT
cord-326228-9x1233q6	62	5	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	62	6	influence	influence	NN
cord-326228-9x1233q6	62	7	PRR	PRR	NNP
cord-326228-9x1233q6	62	8	activity	activity	NN
cord-326228-9x1233q6	62	9	and	and	CC
cord-326228-9x1233q6	62	10	drive	drive	VB
cord-326228-9x1233q6	62	11	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	62	12	responses	response	NNS
cord-326228-9x1233q6	62	13	are	be	VBP
cord-326228-9x1233q6	62	14	important	important	JJ
cord-326228-9x1233q6	62	15	research	research	NN
cord-326228-9x1233q6	62	16	foci	foci	NN
cord-326228-9x1233q6	62	17	for	for	IN
cord-326228-9x1233q6	62	18	understanding	understand	VBG
cord-326228-9x1233q6	62	19	protective	protective	JJ
cord-326228-9x1233q6	62	20	innate	innate	JJ
cord-326228-9x1233q6	62	21	immune	immune	JJ
cord-326228-9x1233q6	62	22	functions	function	NNS
cord-326228-9x1233q6	62	23	during	during	IN
cord-326228-9x1233q6	62	24	host	host	NN
cord-326228-9x1233q6	62	25	defence	defence	NN
cord-326228-9x1233q6	62	26	against	against	IN
cord-326228-9x1233q6	62	27	infection	infection	NN
cord-326228-9x1233q6	62	28	,	,	,
cord-326228-9x1233q6	62	29	as	as	RB
cord-326228-9x1233q6	62	30	well	well	RB
cord-326228-9x1233q6	62	31	as	as	IN
cord-326228-9x1233q6	62	32	innate	innate	JJ
cord-326228-9x1233q6	62	33	immune	immune	JJ
cord-326228-9x1233q6	62	34	pathology	pathology	NN
cord-326228-9x1233q6	62	35	in	in	IN
cord-326228-9x1233q6	62	36	disease	disease	NN
cord-326228-9x1233q6	62	37	.	.	.
cord-326228-9x1233q6	63	1	Mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	63	2	morphology	morphology	NN
cord-326228-9x1233q6	63	3	is	be	VBZ
cord-326228-9x1233q6	63	4	governed	govern	VBN
cord-326228-9x1233q6	63	5	by	by	IN
cord-326228-9x1233q6	63	6	ancient	ancient	JJ
cord-326228-9x1233q6	63	7	and	and	CC
cord-326228-9x1233q6	63	8	highly	highly	RB
cord-326228-9x1233q6	63	9	conserved	conserve	VBN
cord-326228-9x1233q6	63	10	fission	fission	NN
cord-326228-9x1233q6	63	11	and	and	CC
cord-326228-9x1233q6	63	12	fusion	fusion	NN
cord-326228-9x1233q6	63	13	processes	process	NNS
cord-326228-9x1233q6	63	14	.	.	.
cord-326228-9x1233q6	64	1	There	there	EX
cord-326228-9x1233q6	64	2	is	be	VBZ
cord-326228-9x1233q6	64	3	always	always	RB
cord-326228-9x1233q6	64	4	a	a	DT
cord-326228-9x1233q6	64	5	dynamic	dynamic	JJ
cord-326228-9x1233q6	64	6	equilibrium	equilibrium	NN
cord-326228-9x1233q6	64	7	between	between	IN
cord-326228-9x1233q6	64	8	fission	fission	NN
cord-326228-9x1233q6	64	9	and	and	CC
cord-326228-9x1233q6	64	10	fusion	fusion	NN
cord-326228-9x1233q6	64	11	.	.	.
cord-326228-9x1233q6	65	1	These	these	DT
cord-326228-9x1233q6	65	2	competing	compete	VBG
cord-326228-9x1233q6	65	3	processes	process	NNS
cord-326228-9x1233q6	65	4	are	be	VBP
cord-326228-9x1233q6	65	5	balanced	balanced	JJ
cord-326228-9x1233q6	65	6	to	to	TO
cord-326228-9x1233q6	65	7	maintain	maintain	VB
cord-326228-9x1233q6	65	8	tubular	tubular	JJ
cord-326228-9x1233q6	65	9	networks	network	NNS
cord-326228-9x1233q6	65	10	of	of	IN
cord-326228-9x1233q6	65	11	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	65	12	in	in	IN
cord-326228-9x1233q6	65	13	healthy	healthy	JJ
cord-326228-9x1233q6	65	14	cells	cell	NNS
cord-326228-9x1233q6	65	15	.	.	.
cord-326228-9x1233q6	66	1	Under	under	IN
cord-326228-9x1233q6	66	2	stress	stress	NN
cord-326228-9x1233q6	66	3	,	,	,
cord-326228-9x1233q6	66	4	the	the	DT
cord-326228-9x1233q6	66	5	balance	balance	NN
cord-326228-9x1233q6	66	6	is	be	VBZ
cord-326228-9x1233q6	66	7	tipped	tip	VBN
cord-326228-9x1233q6	66	8	in	in	IN
cord-326228-9x1233q6	66	9	favor	favor	NN
cord-326228-9x1233q6	66	10	of	of	IN
cord-326228-9x1233q6	66	11	fission	fission	NN
cord-326228-9x1233q6	66	12	,	,	,
cord-326228-9x1233q6	66	13	to	to	TO
cord-326228-9x1233q6	66	14	enable	enable	VB
cord-326228-9x1233q6	66	15	rapid	rapid	JJ
cord-326228-9x1233q6	66	16	amputation	amputation	NN
cord-326228-9x1233q6	66	17	and	and	CC
cord-326228-9x1233q6	66	18	degradation	degradation	NN
cord-326228-9x1233q6	66	19	of	of	IN
cord-326228-9x1233q6	66	20	damaged	damaged	JJ
cord-326228-9x1233q6	66	21	sections	section	NNS
cord-326228-9x1233q6	66	22	of	of	IN
cord-326228-9x1233q6	66	23	the	the	DT
cord-326228-9x1233q6	66	24	mitochondrion	mitochondrion	NN
cord-326228-9x1233q6	66	25	.	.	.
cord-326228-9x1233q6	67	1	16	16	CD
cord-326228-9x1233q6	67	2	Asymmetric	asymmetric	JJ
cord-326228-9x1233q6	67	3	fission	fission	NN
cord-326228-9x1233q6	67	4	yields	yield	NNS
cord-326228-9x1233q6	67	5	daughter	daughter	NN
cord-326228-9x1233q6	67	6	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	67	7	with	with	IN
cord-326228-9x1233q6	67	8	varying	vary	VBG
cord-326228-9x1233q6	67	9	membrane	membrane	NN
cord-326228-9x1233q6	67	10	potential	potential	NN
cord-326228-9x1233q6	67	11	.	.	.
cord-326228-9x1233q6	68	1	17	17	CD
cord-326228-9x1233q6	68	2	Daughter	Daughter	NNP
cord-326228-9x1233q6	68	3	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	68	4	with	with	IN
cord-326228-9x1233q6	68	5	regions	region	NNS
cord-326228-9x1233q6	68	6	of	of	IN
cord-326228-9x1233q6	68	7	decreased	decrease	VBN
cord-326228-9x1233q6	68	8	membrane	membrane	NN
cord-326228-9x1233q6	68	9	potential	potential	NN
cord-326228-9x1233q6	68	10	are	be	VBP
cord-326228-9x1233q6	68	11	then	then	RB
cord-326228-9x1233q6	68	12	selectively	selectively	RB
cord-326228-9x1233q6	68	13	removed	remove	VBN
cord-326228-9x1233q6	68	14	by	by	IN
cord-326228-9x1233q6	68	15	a	a	DT
cord-326228-9x1233q6	68	16	specialised	specialised	JJ
cord-326228-9x1233q6	68	17	form	form	NN
cord-326228-9x1233q6	68	18	of	of	IN
cord-326228-9x1233q6	68	19	autophagy	autophagy	NN
cord-326228-9x1233q6	68	20	called	call	VBN
cord-326228-9x1233q6	68	21	mitophagy	mitophagy	NN
cord-326228-9x1233q6	68	22	.	.	.
cord-326228-9x1233q6	69	1	17	17	CD
cord-326228-9x1233q6	69	2	,	,	,
cord-326228-9x1233q6	69	3	18	18	CD
cord-326228-9x1233q6	70	1	The	the	DT
cord-326228-9x1233q6	70	2	GTPase	GTPase	NNP
cord-326228-9x1233q6	70	3	DRP1	DRP1	NNP
cord-326228-9x1233q6	70	4	is	be	VBZ
cord-326228-9x1233q6	70	5	the	the	DT
cord-326228-9x1233q6	70	6	primary	primary	JJ
cord-326228-9x1233q6	70	7	mediator	mediator	NN
cord-326228-9x1233q6	70	8	of	of	IN
cord-326228-9x1233q6	70	9	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	70	10	fission	fission	NN
cord-326228-9x1233q6	70	11	.	.	.
cord-326228-9x1233q6	71	1	DRP1	DRP1	NNP
cord-326228-9x1233q6	71	2	self	self	NN
cord-326228-9x1233q6	71	3	-	-	HYPH
cord-326228-9x1233q6	71	4	assembles	assemble	VBZ
cord-326228-9x1233q6	71	5	into	into	IN
cord-326228-9x1233q6	71	6	oligomers	oligomer	NNS
cord-326228-9x1233q6	71	7	,	,	,
cord-326228-9x1233q6	71	8	coiling	coil	VBG
cord-326228-9x1233q6	71	9	around	around	IN
cord-326228-9x1233q6	71	10	the	the	DT
cord-326228-9x1233q6	71	11	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	71	12	outer	outer	JJ
cord-326228-9x1233q6	71	13	membrane	membrane	NN
cord-326228-9x1233q6	71	14	to	to	TO
cord-326228-9x1233q6	71	15	'	'	``
cord-326228-9x1233q6	71	16	pinch	pinch	VB
cord-326228-9x1233q6	71	17	'	'	''
cord-326228-9x1233q6	71	18	the	the	DT
cord-326228-9x1233q6	71	19	tubular	tubular	JJ
cord-326228-9x1233q6	71	20	network	network	NN
cord-326228-9x1233q6	71	21	and	and	CC
cord-326228-9x1233q6	71	22	fragment	fragment	VB
cord-326228-9x1233q6	71	23	it	-PRON-	PRP
cord-326228-9x1233q6	71	24	into	into	IN
cord-326228-9x1233q6	71	25	smaller	small	JJR
cord-326228-9x1233q6	71	26	,	,	,
cord-326228-9x1233q6	71	27	discrete	discrete	JJ
cord-326228-9x1233q6	71	28	segments	segment	NNS
cord-326228-9x1233q6	71	29	19	19	CD
cord-326228-9x1233q6	71	30	,	,	,
cord-326228-9x1233q6	71	31	20	20	CD
cord-326228-9x1233q6	71	32	(	(	-LRB-
cord-326228-9x1233q6	71	33	Figure	figure	NN
cord-326228-9x1233q6	71	34	1	1	CD
cord-326228-9x1233q6	71	35	)	)	-RRB-
cord-326228-9x1233q6	71	36	.	.	.
cord-326228-9x1233q6	72	1	It	-PRON-	PRP
cord-326228-9x1233q6	72	2	is	be	VBZ
cord-326228-9x1233q6	72	3	currently	currently	RB
cord-326228-9x1233q6	72	4	unclear	unclear	JJ
cord-326228-9x1233q6	72	5	how	how	WRB
cord-326228-9x1233q6	72	6	DRP1	DRP1	NNP
cord-326228-9x1233q6	72	7	constriction	constriction	NN
cord-326228-9x1233q6	72	8	sites	site	NNS
cord-326228-9x1233q6	72	9	are	be	VBP
cord-326228-9x1233q6	72	10	specified	specify	VBN
cord-326228-9x1233q6	72	11	;	;	:
cord-326228-9x1233q6	72	12	however	however	RB
cord-326228-9x1233q6	72	13	,	,	,
cord-326228-9x1233q6	72	14	this	this	DT
cord-326228-9x1233q6	72	15	may	may	MD
cord-326228-9x1233q6	72	16	involve	involve	VB
cord-326228-9x1233q6	72	17	ER	ER	NNP
cord-326228-9x1233q6	72	18	mitochondria	mitochondria	NN
cord-326228-9x1233q6	72	19	-	-	HYPH
cord-326228-9x1233q6	72	20	associated	associate	VBN
cord-326228-9x1233q6	72	21	membranes	membrane	NNS
cord-326228-9x1233q6	72	22	(	(	-LRB-
cord-326228-9x1233q6	72	23	MAMs	MAMs	NNP
cord-326228-9x1233q6	72	24	)	)	-RRB-
cord-326228-9x1233q6	72	25	21	21	CD
cord-326228-9x1233q6	72	26	and	and	CC
cord-326228-9x1233q6	72	27	the	the	DT
cord-326228-9x1233q6	72	28	actin	actin	NN
cord-326228-9x1233q6	72	29	cytoskeleton	cytoskeleton	NN
cord-326228-9x1233q6	72	30	.	.	.
cord-326228-9x1233q6	73	1	22	22	CD
cord-326228-9x1233q6	73	2	NLRP3	nlrp3	NN
cord-326228-9x1233q6	73	3	activation	activation	NN
cord-326228-9x1233q6	73	4	by	by	IN
cord-326228-9x1233q6	73	5	K	k	NN
cord-326228-9x1233q6	73	6	+	+	CC
cord-326228-9x1233q6	73	7	efflux	efflux	NN
cord-326228-9x1233q6	73	8	-	-	HYPH
cord-326228-9x1233q6	73	9	inducing	induce	VBG
cord-326228-9x1233q6	73	10	agents	agent	NNS
cord-326228-9x1233q6	73	11	(	(	-LRB-
cord-326228-9x1233q6	73	12	ATP	ATP	NNP
cord-326228-9x1233q6	73	13	,	,	,
cord-326228-9x1233q6	73	14	MSU	MSU	NNP
cord-326228-9x1233q6	73	15	,	,	,
cord-326228-9x1233q6	73	16	silica	silica	NN
cord-326228-9x1233q6	73	17	,	,	,
cord-326228-9x1233q6	73	18	nigericin	nigericin	NNS
cord-326228-9x1233q6	73	19	)	)	-RRB-
cord-326228-9x1233q6	73	20	is	be	VBZ
cord-326228-9x1233q6	73	21	reported	report	VBN
cord-326228-9x1233q6	73	22	to	to	TO
cord-326228-9x1233q6	73	23	be	be	VB
cord-326228-9x1233q6	73	24	partially	partially	RB
cord-326228-9x1233q6	73	25	dependent	dependent	JJ
cord-326228-9x1233q6	73	26	on	on	IN
cord-326228-9x1233q6	73	27	phosphoglycerate	phosphoglycerate	JJ
cord-326228-9x1233q6	73	28	mutase	mutase	NNP
cord-326228-9x1233q6	73	29	family	family	NN
cord-326228-9x1233q6	73	30	member	member	NN
cord-326228-9x1233q6	73	31	5	5	CD
cord-326228-9x1233q6	73	32	(	(	-LRB-
cord-326228-9x1233q6	73	33	PGAM5	PGAM5	NNP
cord-326228-9x1233q6	73	34	)	)	-RRB-
cord-326228-9x1233q6	73	35	,	,	,
cord-326228-9x1233q6	73	36	a	a	DT
cord-326228-9x1233q6	73	37	serine	serine	NN
cord-326228-9x1233q6	73	38	/	/	SYM
cord-326228-9x1233q6	73	39	threonine	threonine	NN
cord-326228-9x1233q6	73	40	phosphatase	phosphatase	NN
cord-326228-9x1233q6	73	41	located	locate	VBN
cord-326228-9x1233q6	73	42	on	on	IN
cord-326228-9x1233q6	73	43	the	the	DT
cord-326228-9x1233q6	73	44	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	73	45	outer	outer	JJ
cord-326228-9x1233q6	73	46	membrane	membrane	NN
cord-326228-9x1233q6	73	47	.	.	.
cord-326228-9x1233q6	74	1	23	23	CD
cord-326228-9x1233q6	74	2	PGAM5	PGAM5	NNS
cord-326228-9x1233q6	74	3	may	may	MD
cord-326228-9x1233q6	74	4	recruit	recruit	VB
cord-326228-9x1233q6	74	5	and	and	CC
cord-326228-9x1233q6	74	6	dephosphorylate	dephosphorylate	NNP
cord-326228-9x1233q6	74	7	DRP1	DRP1	NNP
cord-326228-9x1233q6	74	8	,	,	,
cord-326228-9x1233q6	74	9	activating	activate	VBG
cord-326228-9x1233q6	74	10	DRP1	DRP1	NNP
cord-326228-9x1233q6	74	11	and	and	CC
cord-326228-9x1233q6	74	12	promoting	promote	VBG
cord-326228-9x1233q6	74	13	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	74	14	fission	fission	NN
cord-326228-9x1233q6	74	15	.	.	.
cord-326228-9x1233q6	75	1	24	24	CD
cord-326228-9x1233q6	76	1	The	the	DT
cord-326228-9x1233q6	76	2	inner	inner	JJ
cord-326228-9x1233q6	76	3	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	76	4	membrane	membrane	NN
cord-326228-9x1233q6	76	5	has	have	VBZ
cord-326228-9x1233q6	76	6	its	-PRON-	PRP$
cord-326228-9x1233q6	76	7	own	own	JJ
cord-326228-9x1233q6	76	8	fission	fission	NN
cord-326228-9x1233q6	76	9	machinery	machinery	NN
cord-326228-9x1233q6	76	10	that	that	WDT
cord-326228-9x1233q6	76	11	operates	operate	VBZ
cord-326228-9x1233q6	76	12	in	in	IN
cord-326228-9x1233q6	76	13	parallel	parallel	NN
cord-326228-9x1233q6	76	14	to	to	IN
cord-326228-9x1233q6	76	15	the	the	DT
cord-326228-9x1233q6	76	16	outer	outer	JJ
cord-326228-9x1233q6	76	17	membrane	membrane	NN
cord-326228-9x1233q6	76	18	.	.	.
cord-326228-9x1233q6	77	1	Another	another	DT
cord-326228-9x1233q6	77	2	GTPase	GTPase	NNP
cord-326228-9x1233q6	77	3	,	,	,
cord-326228-9x1233q6	77	4	OPA1	OPA1	NNP
cord-326228-9x1233q6	77	5	,	,	,
cord-326228-9x1233q6	77	6	maintains	maintain	VBZ
cord-326228-9x1233q6	77	7	the	the	DT
cord-326228-9x1233q6	77	8	integrity	integrity	NN
cord-326228-9x1233q6	77	9	of	of	IN
cord-326228-9x1233q6	77	10	the	the	DT
cord-326228-9x1233q6	77	11	matrix	matrix	NN
cord-326228-9x1233q6	77	12	.	.	.
cord-326228-9x1233q6	78	1	OPA1	opa1	JJ
cord-326228-9x1233q6	78	2	loss	loss	NN
cord-326228-9x1233q6	78	3	or	or	CC
cord-326228-9x1233q6	78	4	functional	functional	JJ
cord-326228-9x1233q6	78	5	downregulation	downregulation	NN
cord-326228-9x1233q6	78	6	leads	lead	VBZ
cord-326228-9x1233q6	78	7	to	to	IN
cord-326228-9x1233q6	78	8	inner	inner	JJ
cord-326228-9x1233q6	78	9	membrane	membrane	NN
cord-326228-9x1233q6	78	10	fission	fission	NN
cord-326228-9x1233q6	78	11	.	.	.
cord-326228-9x1233q6	79	1	[	[	-LRB-
cord-326228-9x1233q6	79	2	25	25	CD
cord-326228-9x1233q6	79	3	]	]	-RRB-
cord-326228-9x1233q6	79	4	[	[	-LRB-
cord-326228-9x1233q6	79	5	26	26	CD
cord-326228-9x1233q6	79	6	]	]	-RRB-
cord-326228-9x1233q6	80	1	[	[	-LRB-
cord-326228-9x1233q6	80	2	27	27	CD
cord-326228-9x1233q6	80	3	]	]	-RRB-
cord-326228-9x1233q6	81	1	How	how	WRB
cord-326228-9x1233q6	81	2	DRP1	DRP1	NNP
cord-326228-9x1233q6	81	3	and	and	CC
cord-326228-9x1233q6	81	4	OPA1	OPA1	NNP
cord-326228-9x1233q6	81	5	coordinate	coordinate	JJ
cord-326228-9x1233q6	81	6	events	event	NNS
cord-326228-9x1233q6	81	7	at	at	IN
cord-326228-9x1233q6	81	8	both	both	DT
cord-326228-9x1233q6	81	9	membranes	membrane	NNS
cord-326228-9x1233q6	81	10	to	to	TO
cord-326228-9x1233q6	81	11	execute	execute	VB
cord-326228-9x1233q6	81	12	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	81	13	fission	fission	NN
cord-326228-9x1233q6	81	14	is	be	VBZ
cord-326228-9x1233q6	81	15	unclear	unclear	JJ
cord-326228-9x1233q6	81	16	,	,	,
cord-326228-9x1233q6	81	17	and	and	CC
cord-326228-9x1233q6	81	18	yet	yet	RB
cord-326228-9x1233q6	81	19	they	-PRON-	PRP
cord-326228-9x1233q6	81	20	do	do	VBP
cord-326228-9x1233q6	81	21	so	so	RB
cord-326228-9x1233q6	81	22	seamlessly	seamlessly	RB
cord-326228-9x1233q6	81	23	.	.	.
cord-326228-9x1233q6	82	1	Both	both	DT
cord-326228-9x1233q6	82	2	proteins	protein	NNS
cord-326228-9x1233q6	82	3	are	be	VBP
cord-326228-9x1233q6	82	4	required	require	VBN
cord-326228-9x1233q6	82	5	for	for	IN
cord-326228-9x1233q6	82	6	effective	effective	JJ
cord-326228-9x1233q6	82	7	mitophagy	mitophagy	NN
cord-326228-9x1233q6	82	8	,	,	,
cord-326228-9x1233q6	82	9	and	and	CC
cord-326228-9x1233q6	82	10	inhibition	inhibition	NN
cord-326228-9x1233q6	82	11	of	of	IN
cord-326228-9x1233q6	82	12	either	either	DT
cord-326228-9x1233q6	82	13	is	be	VBZ
cord-326228-9x1233q6	82	14	sufficient	sufficient	JJ
cord-326228-9x1233q6	82	15	to	to	TO
cord-326228-9x1233q6	82	16	induce	induce	VB
cord-326228-9x1233q6	82	17	the	the	DT
cord-326228-9x1233q6	82	18	accumulation	accumulation	NN
cord-326228-9x1233q6	82	19	of	of	IN
cord-326228-9x1233q6	82	20	damaged	damaged	JJ
cord-326228-9x1233q6	82	21	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	82	22	.	.	.
cord-326228-9x1233q6	83	1	17	17	CD
cord-326228-9x1233q6	84	1	The	the	DT
cord-326228-9x1233q6	84	2	reverse	reverse	JJ
cord-326228-9x1233q6	84	3	process	process	NN
cord-326228-9x1233q6	84	4	of	of	IN
cord-326228-9x1233q6	84	5	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	84	6	fusion	fusion	NN
cord-326228-9x1233q6	84	7	is	be	VBZ
cord-326228-9x1233q6	84	8	induced	induce	VBN
cord-326228-9x1233q6	84	9	by	by	IN
cord-326228-9x1233q6	84	10	suppression	suppression	NN
cord-326228-9x1233q6	84	11	of	of	IN
cord-326228-9x1233q6	84	12	the	the	DT
cord-326228-9x1233q6	84	13	fission	fission	NN
cord-326228-9x1233q6	84	14	machinery	machinery	NN
cord-326228-9x1233q6	84	15	or	or	CC
cord-326228-9x1233q6	84	16	upregulation	upregulation	NN
cord-326228-9x1233q6	84	17	of	of	IN
cord-326228-9x1233q6	84	18	fusion	fusion	NN
cord-326228-9x1233q6	84	19	machinery	machinery	NN
cord-326228-9x1233q6	84	20	.	.	.
cord-326228-9x1233q6	85	1	In	in	IN
cord-326228-9x1233q6	85	2	mammals	mammal	NNS
cord-326228-9x1233q6	85	3	,	,	,
cord-326228-9x1233q6	85	4	mitofusins	mitofusins	NNP
cord-326228-9x1233q6	85	5	(	(	-LRB-
cord-326228-9x1233q6	85	6	MFNs	MFNs	NNP
cord-326228-9x1233q6	85	7	)	)	-RRB-
cord-326228-9x1233q6	85	8	1	1	CD
cord-326228-9x1233q6	85	9	and	and	CC
cord-326228-9x1233q6	85	10	2	2	LS
cord-326228-9x1233q6	85	11	(	(	-LRB-
cord-326228-9x1233q6	85	12	Figure	figure	NN
cord-326228-9x1233q6	85	13	1	1	CD
cord-326228-9x1233q6	85	14	)	)	-RRB-
cord-326228-9x1233q6	85	15	participate	participate	VB
cord-326228-9x1233q6	85	16	in	in	IN
cord-326228-9x1233q6	85	17	multiprotein	multiprotein	NNP
cord-326228-9x1233q6	85	18	complexes	complex	NNS
cord-326228-9x1233q6	85	19	to	to	TO
cord-326228-9x1233q6	85	20	fuse	fuse	VB
cord-326228-9x1233q6	85	21	fragmented	fragmented	JJ
cord-326228-9x1233q6	85	22	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	85	23	to	to	TO
cord-326228-9x1233q6	85	24	form	form	VB
cord-326228-9x1233q6	85	25	a	a	DT
cord-326228-9x1233q6	85	26	tubular	tubular	JJ
cord-326228-9x1233q6	85	27	network	network	NN
cord-326228-9x1233q6	85	28	.	.	.
cord-326228-9x1233q6	86	1	28	28	CD
cord-326228-9x1233q6	86	2	,	,	,
cord-326228-9x1233q6	86	3	29	29	CD
cord-326228-9x1233q6	87	1	This	this	DT
cord-326228-9x1233q6	87	2	dynamic	dynamic	JJ
cord-326228-9x1233q6	87	3	regulation	regulation	NN
cord-326228-9x1233q6	87	4	of	of	IN
cord-326228-9x1233q6	87	5	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	87	6	morphology	morphology	NN
cord-326228-9x1233q6	87	7	is	be	VBZ
cord-326228-9x1233q6	87	8	important	important	JJ
cord-326228-9x1233q6	87	9	for	for	IN
cord-326228-9x1233q6	87	10	repair	repair	NN
cord-326228-9x1233q6	87	11	,	,	,
cord-326228-9x1233q6	87	12	equal	equal	JJ
cord-326228-9x1233q6	87	13	distribution	distribution	NN
cord-326228-9x1233q6	87	14	of	of	IN
cord-326228-9x1233q6	87	15	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	87	16	mass	mass	NN
cord-326228-9x1233q6	87	17	during	during	IN
cord-326228-9x1233q6	87	18	replication	replication	NN
cord-326228-9x1233q6	87	19	,	,	,
cord-326228-9x1233q6	87	20	and	and	CC
cord-326228-9x1233q6	87	21	starvation	starvation	NN
cord-326228-9x1233q6	87	22	-	-	HYPH
cord-326228-9x1233q6	87	23	induced	induce	VBN
cord-326228-9x1233q6	87	24	metabolic	metabolic	JJ
cord-326228-9x1233q6	87	25	responses	response	NNS
cord-326228-9x1233q6	87	26	.	.	.
cord-326228-9x1233q6	88	1	30	30	CD
cord-326228-9x1233q6	88	2	Mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	88	3	are	be	VBP
cord-326228-9x1233q6	88	4	labile	labile	JJ
cord-326228-9x1233q6	88	5	and	and	CC
cord-326228-9x1233q6	88	6	responsive	responsive	JJ
cord-326228-9x1233q6	88	7	organelles	organelle	NNS
cord-326228-9x1233q6	88	8	that	that	WDT
cord-326228-9x1233q6	88	9	modulate	modulate	VBP
cord-326228-9x1233q6	88	10	immune	immune	JJ
cord-326228-9x1233q6	88	11	signalling	signalling	NN
cord-326228-9x1233q6	88	12	,	,	,
cord-326228-9x1233q6	88	13	as	as	IN
cord-326228-9x1233q6	88	14	is	be	VBZ
cord-326228-9x1233q6	88	15	highlighted	highlight	VBN
cord-326228-9x1233q6	88	16	by	by	IN
cord-326228-9x1233q6	88	17	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	88	18	dynamics	dynamic	NNS
cord-326228-9x1233q6	88	19	during	during	IN
cord-326228-9x1233q6	88	20	microbial	microbial	JJ
cord-326228-9x1233q6	88	21	infection	infection	NN
cord-326228-9x1233q6	88	22	.	.	.
cord-326228-9x1233q6	89	1	Some	some	DT
cord-326228-9x1233q6	89	2	viruses	virus	NNS
cord-326228-9x1233q6	89	3	influence	influence	VBP
cord-326228-9x1233q6	89	4	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	89	5	mass	mass	NN
cord-326228-9x1233q6	89	6	by	by	IN
cord-326228-9x1233q6	89	7	interfering	interfere	VBG
cord-326228-9x1233q6	89	8	with	with	IN
cord-326228-9x1233q6	89	9	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	89	10	network	network	NN
cord-326228-9x1233q6	89	11	fusion/	fusion/	CD
cord-326228-9x1233q6	89	12	fission	fission	NN
cord-326228-9x1233q6	89	13	dynamics	dynamic	NNS
cord-326228-9x1233q6	89	14	,	,	,
cord-326228-9x1233q6	89	15	to	to	TO
cord-326228-9x1233q6	89	16	create	create	VB
cord-326228-9x1233q6	89	17	a	a	DT
cord-326228-9x1233q6	89	18	favorable	favorable	JJ
cord-326228-9x1233q6	89	19	environment	environment	NN
cord-326228-9x1233q6	89	20	for	for	IN
cord-326228-9x1233q6	89	21	viral	viral	JJ
cord-326228-9x1233q6	89	22	replication	replication	NN
cord-326228-9x1233q6	89	23	.	.	.
cord-326228-9x1233q6	90	1	For	for	IN
cord-326228-9x1233q6	90	2	example	example	NN
cord-326228-9x1233q6	90	3	,	,	,
cord-326228-9x1233q6	90	4	dengue	dengue	NN
cord-326228-9x1233q6	90	5	virus	virus	NN
cord-326228-9x1233q6	90	6	,	,	,
cord-326228-9x1233q6	90	7	31	31	CD
cord-326228-9x1233q6	90	8	,	,	,
cord-326228-9x1233q6	90	9	32	32	CD
cord-326228-9x1233q6	90	10	severe	severe	JJ
cord-326228-9x1233q6	90	11	acute	acute	JJ
cord-326228-9x1233q6	90	12	respiratory	respiratory	JJ
cord-326228-9x1233q6	90	13	syndrome	syndrome	NN
cord-326228-9x1233q6	90	14	-	-	HYPH
cord-326228-9x1233q6	90	15	related	relate	VBN
cord-326228-9x1233q6	90	16	coronavirus	coronavirus	NN
cord-326228-9x1233q6	90	17	(	(	-LRB-
cord-326228-9x1233q6	90	18	SARS	SARS	NNP
cord-326228-9x1233q6	90	19	-	-	HYPH
cord-326228-9x1233q6	90	20	CoV	CoV	NNP
cord-326228-9x1233q6	90	21	)	)	-RRB-
cord-326228-9x1233q6	91	1	33	33	CD
cord-326228-9x1233q6	91	2	and	and	CC
cord-326228-9x1233q6	91	3	human	human	JJ
cord-326228-9x1233q6	91	4	immunodeficiency	immunodeficiency	NN
cord-326228-9x1233q6	91	5	virus	virus	NN
cord-326228-9x1233q6	91	6	(	(	-LRB-
cord-326228-9x1233q6	91	7	HIV	HIV	NNP
cord-326228-9x1233q6	91	8	)	)	-RRB-
cord-326228-9x1233q6	92	1	34	34	CD
cord-326228-9x1233q6	92	2	all	all	DT
cord-326228-9x1233q6	92	3	downregulate	downregulate	VBP
cord-326228-9x1233q6	92	4	DRP1	DRP1	NNP
cord-326228-9x1233q6	92	5	to	to	TO
cord-326228-9x1233q6	92	6	promote	promote	VB
cord-326228-9x1233q6	92	7	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	92	8	fusion	fusion	NN
cord-326228-9x1233q6	92	9	.	.	.
cord-326228-9x1233q6	93	1	In	in	IN
cord-326228-9x1233q6	93	2	addition	addition	NN
cord-326228-9x1233q6	93	3	to	to	IN
cord-326228-9x1233q6	93	4	downregulating	downregulate	VBG
cord-326228-9x1233q6	93	5	DRP1	DRP1	NNP
cord-326228-9x1233q6	93	6	,	,	,
cord-326228-9x1233q6	93	7	the	the	DT
cord-326228-9x1233q6	93	8	HIV	HIV	NNP
cord-326228-9x1233q6	93	9	gp120	gp120	NNP
cord-326228-9x1233q6	93	10	protein	protein	NN
cord-326228-9x1233q6	93	11	upregulates	upregulate	VBZ
cord-326228-9x1233q6	93	12	MFN1	MFN1	NNP
cord-326228-9x1233q6	93	13	,	,	,
cord-326228-9x1233q6	93	14	while	while	IN
cord-326228-9x1233q6	93	15	another	another	DT
cord-326228-9x1233q6	93	16	HIV	HIV	NNP
cord-326228-9x1233q6	93	17	protein	protein	NN
cord-326228-9x1233q6	93	18	,	,	,
cord-326228-9x1233q6	93	19	Vpr	Vpr	NNP
cord-326228-9x1233q6	93	20	,	,	,
cord-326228-9x1233q6	93	21	damages	damage	VBZ
cord-326228-9x1233q6	93	22	the	the	DT
cord-326228-9x1233q6	93	23	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	93	24	outer	outer	JJ
cord-326228-9x1233q6	93	25	membrane	membrane	NN
cord-326228-9x1233q6	93	26	,	,	,
cord-326228-9x1233q6	93	27	which	which	WDT
cord-326228-9x1233q6	93	28	can	can	MD
cord-326228-9x1233q6	93	29	lead	lead	VB
cord-326228-9x1233q6	93	30	to	to	IN
cord-326228-9x1233q6	93	31	loss	loss	NN
cord-326228-9x1233q6	93	32	of	of	IN
cord-326228-9x1233q6	93	33	membrane	membrane	NN
cord-326228-9x1233q6	93	34	potential	potential	NN
cord-326228-9x1233q6	93	35	,	,	,
cord-326228-9x1233q6	93	36	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	93	37	dysfunction	dysfunction	NN
cord-326228-9x1233q6	93	38	and	and	CC
cord-326228-9x1233q6	93	39	apoptosis	apoptosis	NN
cord-326228-9x1233q6	93	40	.	.	.
cord-326228-9x1233q6	94	1	34	34	CD
cord-326228-9x1233q6	94	2	HIV	HIV	NNP
cord-326228-9x1233q6	94	3	induces	induce	VBZ
cord-326228-9x1233q6	94	4	expression	expression	NN
cord-326228-9x1233q6	94	5	of	of	IN
cord-326228-9x1233q6	94	6	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	94	7	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	94	8	components	component	NNS
cord-326228-9x1233q6	94	9	in	in	IN
cord-326228-9x1233q6	94	10	patient	patient	JJ
cord-326228-9x1233q6	94	11	brains	brain	NNS
cord-326228-9x1233q6	94	12	.	.	.
cord-326228-9x1233q6	95	1	35	35	CD
cord-326228-9x1233q6	95	2	,	,	,
cord-326228-9x1233q6	95	3	36	36	CD
cord-326228-9x1233q6	96	1	Given	give	VBN
cord-326228-9x1233q6	96	2	that	that	IN
cord-326228-9x1233q6	96	3	NLRP3	nlrp3	NN
cord-326228-9x1233q6	96	4	inflammasome	inflammasome	NN
cord-326228-9x1233q6	96	5	activity	activity	NN
cord-326228-9x1233q6	96	6	in	in	IN
cord-326228-9x1233q6	96	7	the	the	DT
cord-326228-9x1233q6	96	8	brain	brain	NN
cord-326228-9x1233q6	96	9	is	be	VBZ
cord-326228-9x1233q6	96	10	linked	link	VBN
cord-326228-9x1233q6	96	11	to	to	IN
cord-326228-9x1233q6	96	12	neurodegeneration	neurodegeneration	NN
cord-326228-9x1233q6	96	13	,	,	,
cord-326228-9x1233q6	96	14	37,38	37,38	CD
cord-326228-9x1233q6	96	15	viral	viral	JJ
cord-326228-9x1233q6	96	16	promotion	promotion	NN
cord-326228-9x1233q6	96	17	of	of	IN
cord-326228-9x1233q6	96	18	NLRP3	nlrp3	NN
cord-326228-9x1233q6	96	19	signalling	signalling	NN
cord-326228-9x1233q6	96	20	may	may	MD
cord-326228-9x1233q6	96	21	contribute	contribute	VB
cord-326228-9x1233q6	96	22	to	to	IN
cord-326228-9x1233q6	96	23	neurological	neurological	JJ
cord-326228-9x1233q6	96	24	disorders	disorder	NNS
cord-326228-9x1233q6	96	25	that	that	WDT
cord-326228-9x1233q6	96	26	are	be	VBP
cord-326228-9x1233q6	96	27	often	often	RB
cord-326228-9x1233q6	96	28	a	a	DT
cord-326228-9x1233q6	96	29	comorbidity	comorbidity	NN
cord-326228-9x1233q6	96	30	of	of	IN
cord-326228-9x1233q6	96	31	chronic	chronic	JJ
cord-326228-9x1233q6	96	32	HIV	HIV	NNP
cord-326228-9x1233q6	96	33	infection	infection	NN
cord-326228-9x1233q6	96	34	.	.	.
cord-326228-9x1233q6	97	1	35	35	CD
cord-326228-9x1233q6	97	2	,	,	,
cord-326228-9x1233q6	97	3	36	36	CD
cord-326228-9x1233q6	97	4	Mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	97	5	are	be	VBP
cord-326228-9x1233q6	97	6	signalling	signal	VBG
cord-326228-9x1233q6	97	7	platforms	platform	NNS
cord-326228-9x1233q6	97	8	for	for	IN
cord-326228-9x1233q6	97	9	antiviral	antiviral	JJ
cord-326228-9x1233q6	97	10	signalling	signalling	NN
cord-326228-9x1233q6	97	11	via	via	IN
cord-326228-9x1233q6	97	12	MAVS	MAVS	NNPS
cord-326228-9x1233q6	97	13	and	and	CC
cord-326228-9x1233q6	97	14	NLRP3	nlrp3	XX
cord-326228-9x1233q6	97	15	,	,	,
cord-326228-9x1233q6	97	16	so	so	RB
cord-326228-9x1233q6	97	17	viral	viral	JJ
cord-326228-9x1233q6	97	18	modulation	modulation	NN
cord-326228-9x1233q6	97	19	of	of	IN
cord-326228-9x1233q6	97	20	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	97	21	may	may	MD
cord-326228-9x1233q6	97	22	be	be	VB
cord-326228-9x1233q6	97	23	a	a	DT
cord-326228-9x1233q6	97	24	mechanism	mechanism	NN
cord-326228-9x1233q6	97	25	to	to	TO
cord-326228-9x1233q6	97	26	suppress	suppress	VB
cord-326228-9x1233q6	97	27	antiviral	antiviral	JJ
cord-326228-9x1233q6	97	28	responses	response	NNS
cord-326228-9x1233q6	97	29	.	.	.
cord-326228-9x1233q6	98	1	MAVS	MAVS	NNP
cord-326228-9x1233q6	98	2	is	be	VBZ
cord-326228-9x1233q6	98	3	a	a	DT
cord-326228-9x1233q6	98	4	signalling	signal	VBG
cord-326228-9x1233q6	98	5	protein	protein	NN
cord-326228-9x1233q6	98	6	activated	activate	VBN
cord-326228-9x1233q6	98	7	downstream	downstream	RB
cord-326228-9x1233q6	98	8	of	of	IN
cord-326228-9x1233q6	98	9	viral	viral	JJ
cord-326228-9x1233q6	98	10	double	double	RB
cord-326228-9x1233q6	98	11	-	-	HYPH
cord-326228-9x1233q6	98	12	stranded	stranded	JJ
cord-326228-9x1233q6	98	13	(	(	-LRB-
cord-326228-9x1233q6	98	14	ds	ds	NNP
cord-326228-9x1233q6	98	15	)	)	-RRB-
cord-326228-9x1233q6	98	16	RNA	RNA	NNP
cord-326228-9x1233q6	98	17	recognition	recognition	NN
cord-326228-9x1233q6	98	18	by	by	IN
cord-326228-9x1233q6	98	19	retinoic	retinoic	JJ
cord-326228-9x1233q6	98	20	acid	acid	NN
cord-326228-9x1233q6	98	21	-	-	HYPH
cord-326228-9x1233q6	98	22	inducible	inducible	JJ
cord-326228-9x1233q6	98	23	gene	gene	NN
cord-326228-9x1233q6	98	24	I	i	NN
cord-326228-9x1233q6	98	25	(	(	-LRB-
cord-326228-9x1233q6	98	26	RIGI	RIGI	NNP
cord-326228-9x1233q6	98	27	)	)	-RRB-
cord-326228-9x1233q6	98	28	and	and	CC
cord-326228-9x1233q6	98	29	melanoma	melanoma	NN
cord-326228-9x1233q6	98	30	differentiation	differentiation	NN
cord-326228-9x1233q6	98	31	-	-	HYPH
cord-326228-9x1233q6	98	32	associated	associate	VBN
cord-326228-9x1233q6	98	33	protein	protein	NN
cord-326228-9x1233q6	98	34	5	5	CD
cord-326228-9x1233q6	98	35	(	(	-LRB-
cord-326228-9x1233q6	98	36	MDA5	MDA5	NNP
cord-326228-9x1233q6	98	37	)	)	-RRB-
cord-326228-9x1233q6	98	38	.	.	.
cord-326228-9x1233q6	99	1	Upon	upon	IN
cord-326228-9x1233q6	99	2	activation	activation	NN
cord-326228-9x1233q6	99	3	,	,	,
cord-326228-9x1233q6	99	4	MAVS	MAVS	NNP
cord-326228-9x1233q6	99	5	induces	induce	VBZ
cord-326228-9x1233q6	99	6	NF	nf	NN
cord-326228-9x1233q6	99	7	-	-	HYPH
cord-326228-9x1233q6	99	8	jB	jb	NN
cord-326228-9x1233q6	99	9	and	and	CC
cord-326228-9x1233q6	99	10	interferon	interferon	NN
cord-326228-9x1233q6	99	11	regulatory	regulatory	JJ
cord-326228-9x1233q6	99	12	factor-3	factor-3	NNP
cord-326228-9x1233q6	100	1	(	(	-LRB-
cord-326228-9x1233q6	100	2	IRF3)-dependent	irf3)-dependent	CD
cord-326228-9x1233q6	100	3	interferon	interferon	NN
cord-326228-9x1233q6	100	4	-	-	HYPH
cord-326228-9x1233q6	100	5	b	b	NN
cord-326228-9x1233q6	100	6	(	(	-LRB-
cord-326228-9x1233q6	100	7	IFN	IFN	NNP
cord-326228-9x1233q6	100	8	-	-	HYPH
cord-326228-9x1233q6	100	9	b	b	LS
cord-326228-9x1233q6	100	10	)	)	-RRB-
cord-326228-9x1233q6	100	11	production	production	NN
cord-326228-9x1233q6	100	12	.	.	.
cord-326228-9x1233q6	101	1	39	39	CD
cord-326228-9x1233q6	101	2	NLRP3	nlrp3	NN
cord-326228-9x1233q6	101	3	is	be	VBZ
cord-326228-9x1233q6	101	4	reported	report	VBN
cord-326228-9x1233q6	101	5	to	to	TO
cord-326228-9x1233q6	101	6	relocate	relocate	VB
cord-326228-9x1233q6	101	7	to	to	IN
cord-326228-9x1233q6	101	8	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	101	9	for	for	IN
cord-326228-9x1233q6	101	10	activation	activation	NN
cord-326228-9x1233q6	101	11	,	,	,
cord-326228-9x1233q6	101	12	where	where	WRB
cord-326228-9x1233q6	101	13	MAVS	MAVS	NNP
cord-326228-9x1233q6	101	14	may	may	MD
cord-326228-9x1233q6	101	15	promote	promote	VB
cord-326228-9x1233q6	101	16	NLRP3	nlrp3	NN
cord-326228-9x1233q6	101	17	signalling	signal	VBG
cord-326228-9x1233q6	101	18	.	.	.
cord-326228-9x1233q6	102	1	11,40	11,40	CD
cord-326228-9x1233q6	102	2	NLRP3	nlrp3	NN
cord-326228-9x1233q6	102	3	can	can	MD
cord-326228-9x1233q6	102	4	also	also	RB
cord-326228-9x1233q6	102	5	sense	sense	VB
cord-326228-9x1233q6	102	6	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	102	7	dysfunction	dysfunction	NN
cord-326228-9x1233q6	102	8	.	.	.
cord-326228-9x1233q6	103	1	9	9	CD
cord-326228-9x1233q6	103	2	Influenza	Influenza	NNP
cord-326228-9x1233q6	103	3	A	A	NNP
cord-326228-9x1233q6	103	4	,	,	,
cord-326228-9x1233q6	103	5	hepatitis	hepatitis	NN
cord-326228-9x1233q6	103	6	B	B	NNP
cord-326228-9x1233q6	103	7	(	(	-LRB-
cord-326228-9x1233q6	103	8	HBV	HBV	NNP
cord-326228-9x1233q6	103	9	)	)	-RRB-
cord-326228-9x1233q6	103	10	and	and	CC
cord-326228-9x1233q6	103	11	hepatitis	hepatitis	NNP
cord-326228-9x1233q6	103	12	C	C	NNP
cord-326228-9x1233q6	103	13	(	(	-LRB-
cord-326228-9x1233q6	103	14	HCV	HCV	NNP
cord-326228-9x1233q6	103	15	)	)	-RRB-
cord-326228-9x1233q6	103	16	manipulate	manipulate	VBP
cord-326228-9x1233q6	103	17	the	the	DT
cord-326228-9x1233q6	103	18	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	103	19	inner	inner	JJ
cord-326228-9x1233q6	103	20	membrane	membrane	NN
cord-326228-9x1233q6	103	21	potential	potential	NN
cord-326228-9x1233q6	103	22	(	(	-LRB-
cord-326228-9x1233q6	103	23	influenza	influenza	NN
cord-326228-9x1233q6	103	24	A	a	NN
cord-326228-9x1233q6	103	25	)	)	-RRB-
cord-326228-9x1233q6	104	1	and	and	CC
cord-326228-9x1233q6	104	2	mitophagy	mitophagy	NNP
cord-326228-9x1233q6	104	3	(	(	-LRB-
cord-326228-9x1233q6	104	4	HBV	HBV	NNP
cord-326228-9x1233q6	104	5	,	,	,
cord-326228-9x1233q6	104	6	HCV	HCV	NNP
cord-326228-9x1233q6	104	7	)	)	-RRB-
cord-326228-9x1233q6	104	8	to	to	TO
cord-326228-9x1233q6	104	9	degrade	degrade	VB
cord-326228-9x1233q6	104	10	the	the	DT
cord-326228-9x1233q6	104	11	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	104	12	network	network	NN
cord-326228-9x1233q6	104	13	,	,	,
cord-326228-9x1233q6	104	14	drive	drive	VB
cord-326228-9x1233q6	104	15	mitophagy	mitophagy	NNS
cord-326228-9x1233q6	104	16	and	and	CC
cord-326228-9x1233q6	104	17	suppress	suppress	VB
cord-326228-9x1233q6	104	18	antiviral	antiviral	JJ
cord-326228-9x1233q6	104	19	signalling	signalling	NN
cord-326228-9x1233q6	104	20	.	.	.
cord-326228-9x1233q6	105	1	[	[	-LRB-
cord-326228-9x1233q6	105	2	41	41	CD
cord-326228-9x1233q6	105	3	]	]	-RRB-
cord-326228-9x1233q6	105	4	[	[	-LRB-
cord-326228-9x1233q6	105	5	42	42	CD
cord-326228-9x1233q6	105	6	]	]	-RRB-
cord-326228-9x1233q6	105	7	[	[	-LRB-
cord-326228-9x1233q6	105	8	43	43	CD
cord-326228-9x1233q6	105	9	]	]	-RRB-
cord-326228-9x1233q6	106	1	The	the	DT
cord-326228-9x1233q6	106	2	influenza	influenza	NN
cord-326228-9x1233q6	106	3	A	a	DT
cord-326228-9x1233q6	106	4	peptide	peptide	NN
cord-326228-9x1233q6	106	5	PB1-F2	PB1-F2	NNP
cord-326228-9x1233q6	106	6	induces	induce	VBZ
cord-326228-9x1233q6	106	7	loss	loss	NN
cord-326228-9x1233q6	106	8	of	of	IN
cord-326228-9x1233q6	106	9	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	106	10	membrane	membrane	NN
cord-326228-9x1233q6	106	11	potential	potential	NN
cord-326228-9x1233q6	106	12	by	by	IN
cord-326228-9x1233q6	106	13	disrupting	disrupt	VBG
cord-326228-9x1233q6	106	14	the	the	DT
cord-326228-9x1233q6	106	15	ADP	ADP	NNP
cord-326228-9x1233q6	106	16	/	/	SYM
cord-326228-9x1233q6	106	17	ATP	ATP	NNP
cord-326228-9x1233q6	106	18	translocase	translocase	NN
cord-326228-9x1233q6	106	19	and	and	CC
cord-326228-9x1233q6	106	20	voltage	voltage	NN
cord-326228-9x1233q6	106	21	-	-	HYPH
cord-326228-9x1233q6	106	22	dependent	dependent	JJ
cord-326228-9x1233q6	106	23	anion	anion	NN
cord-326228-9x1233q6	106	24	channel	channel	NN
cord-326228-9x1233q6	106	25	1	1	CD
cord-326228-9x1233q6	106	26	(	(	-LRB-
cord-326228-9x1233q6	106	27	VDAC1	VDAC1	NNP
cord-326228-9x1233q6	106	28	)	)	-RRB-
cord-326228-9x1233q6	106	29	on	on	IN
cord-326228-9x1233q6	106	30	the	the	DT
cord-326228-9x1233q6	106	31	inner	inner	JJ
cord-326228-9x1233q6	106	32	and	and	CC
cord-326228-9x1233q6	106	33	outer	outer	JJ
cord-326228-9x1233q6	106	34	membranes	membrane	NNS
cord-326228-9x1233q6	106	35	,	,	,
cord-326228-9x1233q6	106	36	respectively	respectively	RB
cord-326228-9x1233q6	106	37	.	.	.
cord-326228-9x1233q6	107	1	41	41	CD
cord-326228-9x1233q6	107	2	HBV	HBV	NNP
cord-326228-9x1233q6	107	3	triggered	trigger	VBD
cord-326228-9x1233q6	107	4	DRP1	DRP1	NNP
cord-326228-9x1233q6	107	5	recruitment	recruitment	NN
cord-326228-9x1233q6	107	6	to	to	IN
cord-326228-9x1233q6	107	7	the	the	DT
cord-326228-9x1233q6	107	8	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	107	9	outer	outer	JJ
cord-326228-9x1233q6	107	10	membrane	membrane	NN
cord-326228-9x1233q6	107	11	,	,	,
cord-326228-9x1233q6	107	12	and	and	CC
cord-326228-9x1233q6	107	13	both	both	CC
cord-326228-9x1233q6	107	14	HBV	HBV	NNP
cord-326228-9x1233q6	107	15	and	and	CC
cord-326228-9x1233q6	107	16	HCV	HCV	NNP
cord-326228-9x1233q6	107	17	stimulate	stimulate	VBP
cord-326228-9x1233q6	107	18	PINK1	PINK1	NNP
cord-326228-9x1233q6	107	19	and	and	CC
cord-326228-9x1233q6	107	20	parkin	parkin	NN
cord-326228-9x1233q6	107	21	to	to	TO
cord-326228-9x1233q6	107	22	upregulate	upregulate	VB
cord-326228-9x1233q6	107	23	mitophagy	mitophagy	NNS
cord-326228-9x1233q6	107	24	.	.	.
cord-326228-9x1233q6	108	1	42	42	CD
cord-326228-9x1233q6	108	2	,	,	,
cord-326228-9x1233q6	108	3	43	43	CD
cord-326228-9x1233q6	109	1	In	in	IN
cord-326228-9x1233q6	109	2	reducing	reduce	VBG
cord-326228-9x1233q6	109	3	the	the	DT
cord-326228-9x1233q6	109	4	overall	overall	JJ
cord-326228-9x1233q6	109	5	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	109	6	volume	volume	NN
cord-326228-9x1233q6	109	7	,	,	,
cord-326228-9x1233q6	109	8	this	this	DT
cord-326228-9x1233q6	109	9	virally	virally	RB
cord-326228-9x1233q6	109	10	induced	induce	VBN
cord-326228-9x1233q6	109	11	fission	fission	NN
cord-326228-9x1233q6	109	12	mechanism	mechanism	NN
cord-326228-9x1233q6	109	13	is	be	VBZ
cord-326228-9x1233q6	109	14	presumed	presume	VBN
cord-326228-9x1233q6	109	15	to	to	TO
cord-326228-9x1233q6	109	16	decrease	decrease	VB
cord-326228-9x1233q6	109	17	the	the	DT
cord-326228-9x1233q6	109	18	cell	cell	NN
cord-326228-9x1233q6	109	19	's	's	POS
cord-326228-9x1233q6	109	20	capacity	capacity	NN
cord-326228-9x1233q6	109	21	for	for	IN
cord-326228-9x1233q6	109	22	MAVS	MAVS	NNPS
cord-326228-9x1233q6	109	23	and	and	CC
cord-326228-9x1233q6	109	24	IFNdependent	ifndependent	NN
cord-326228-9x1233q6	109	25	antiviral	antiviral	JJ
cord-326228-9x1233q6	109	26	signalling	signalling	NN
cord-326228-9x1233q6	109	27	and	and	CC
cord-326228-9x1233q6	109	28	therefore	therefore	RB
cord-326228-9x1233q6	109	29	advantage	advantage	VB
cord-326228-9x1233q6	109	30	the	the	DT
cord-326228-9x1233q6	109	31	virus	virus	NN
cord-326228-9x1233q6	109	32	.	.	.
cord-326228-9x1233q6	110	1	34	34	CD
cord-326228-9x1233q6	111	1	By	by	IN
cord-326228-9x1233q6	111	2	blocking	block	VBG
cord-326228-9x1233q6	111	3	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	111	4	viral	viral	JJ
cord-326228-9x1233q6	111	5	recognition	recognition	NN
cord-326228-9x1233q6	111	6	pathways	pathway	NNS
cord-326228-9x1233q6	111	7	,	,	,
cord-326228-9x1233q6	111	8	these	these	DT
cord-326228-9x1233q6	111	9	viral	viral	JJ
cord-326228-9x1233q6	111	10	offensive	offensive	JJ
cord-326228-9x1233q6	111	11	tactics	tactic	NNS
cord-326228-9x1233q6	111	12	boost	boost	VBP
cord-326228-9x1233q6	111	13	viral	viral	JJ
cord-326228-9x1233q6	111	14	replication	replication	NN
cord-326228-9x1233q6	111	15	.	.	.
cord-326228-9x1233q6	112	1	Many	many	JJ
cord-326228-9x1233q6	112	2	such	such	JJ
cord-326228-9x1233q6	112	3	viruses	virus	NNS
cord-326228-9x1233q6	112	4	that	that	WDT
cord-326228-9x1233q6	112	5	manipulate	manipulate	VBP
cord-326228-9x1233q6	112	6	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	112	7	dynamics	dynamic	NNS
cord-326228-9x1233q6	112	8	activate	activate	VBP
cord-326228-9x1233q6	112	9	the	the	DT
cord-326228-9x1233q6	112	10	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	112	11	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	112	12	or	or	CC
cord-326228-9x1233q6	112	13	evade	evade	VB
cord-326228-9x1233q6	112	14	detection	detection	NN
cord-326228-9x1233q6	112	15	by	by	IN
cord-326228-9x1233q6	112	16	this	this	DT
cord-326228-9x1233q6	112	17	immune	immune	JJ
cord-326228-9x1233q6	112	18	sentinel	sentinel	NN
cord-326228-9x1233q6	112	19	.	.	.
cord-326228-9x1233q6	113	1	It	-PRON-	PRP
cord-326228-9x1233q6	113	2	is	be	VBZ
cord-326228-9x1233q6	113	3	possible	possible	JJ
cord-326228-9x1233q6	113	4	that	that	IN
cord-326228-9x1233q6	113	5	these	these	DT
cord-326228-9x1233q6	113	6	observations	observation	NNS
cord-326228-9x1233q6	113	7	are	be	VBP
cord-326228-9x1233q6	113	8	linked	link	VBN
cord-326228-9x1233q6	113	9	,	,	,
cord-326228-9x1233q6	113	10	that	that	DT
cord-326228-9x1233q6	113	11	is	be	VBZ
cord-326228-9x1233q6	113	12	that	that	IN
cord-326228-9x1233q6	113	13	NLRP3	nlrp3	NN
cord-326228-9x1233q6	113	14	may	may	MD
cord-326228-9x1233q6	113	15	sense	sense	VB
cord-326228-9x1233q6	113	16	virally	virally	RB
cord-326228-9x1233q6	113	17	induced	induce	VBN
cord-326228-9x1233q6	113	18	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	113	19	dysfunction	dysfunction	NN
cord-326228-9x1233q6	113	20	,	,	,
cord-326228-9x1233q6	113	21	while	while	IN
cord-326228-9x1233q6	113	22	other	other	JJ
cord-326228-9x1233q6	113	23	viruses	virus	NNS
cord-326228-9x1233q6	113	24	that	that	WDT
cord-326228-9x1233q6	113	25	can	can	MD
cord-326228-9x1233q6	113	26	manipulate	manipulate	VB
cord-326228-9x1233q6	113	27	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	113	28	dynamics	dynamic	NNS
cord-326228-9x1233q6	113	29	without	without	IN
cord-326228-9x1233q6	113	30	causing	cause	VBG
cord-326228-9x1233q6	113	31	cell	cell	NN
cord-326228-9x1233q6	113	32	stress	stress	NN
cord-326228-9x1233q6	113	33	may	may	MD
cord-326228-9x1233q6	113	34	evade	evade	VB
cord-326228-9x1233q6	113	35	detection	detection	NN
cord-326228-9x1233q6	113	36	.	.	.
cord-326228-9x1233q6	114	1	Dengue	dengue	NN
cord-326228-9x1233q6	114	2	virus	virus	NN
cord-326228-9x1233q6	114	3	,	,	,
cord-326228-9x1233q6	114	4	influenza	influenza	NN
cord-326228-9x1233q6	114	5	,	,	,
cord-326228-9x1233q6	114	6	HCV	HCV	NNP
cord-326228-9x1233q6	114	7	,	,	,
cord-326228-9x1233q6	114	8	encephalomyocarditis	encephalomyocarditis	NNP
cord-326228-9x1233q6	114	9	virus	virus	NN
cord-326228-9x1233q6	114	10	(	(	-LRB-
cord-326228-9x1233q6	114	11	EMCV	EMCV	NNP
cord-326228-9x1233q6	114	12	)	)	-RRB-
cord-326228-9x1233q6	114	13	,	,	,
cord-326228-9x1233q6	114	14	vesicular	vesicular	JJ
cord-326228-9x1233q6	114	15	stomatitis	stomatitis	NN
cord-326228-9x1233q6	114	16	virus	virus	NN
cord-326228-9x1233q6	114	17	(	(	-LRB-
cord-326228-9x1233q6	114	18	VSV	VSV	NNP
cord-326228-9x1233q6	114	19	)	)	-RRB-
cord-326228-9x1233q6	114	20	,	,	,
cord-326228-9x1233q6	114	21	herpes	herpes	NN
cord-326228-9x1233q6	114	22	simplex	simplex	NN
cord-326228-9x1233q6	114	23	virus-1	virus-1	NN
cord-326228-9x1233q6	114	24	(	(	-LRB-
cord-326228-9x1233q6	114	25	HSV-1	hsv-1	NN
cord-326228-9x1233q6	114	26	)	)	-RRB-
cord-326228-9x1233q6	114	27	and	and	CC
cord-326228-9x1233q6	115	1	SARS	SARS	NNP
cord-326228-9x1233q6	115	2	-	-	HYPH
cord-326228-9x1233q6	115	3	CoV	CoV	NNP
cord-326228-9x1233q6	115	4	activate	activate	VBP
cord-326228-9x1233q6	115	5	NLRP3	nlrp3	NN
cord-326228-9x1233q6	115	6	,	,	,
cord-326228-9x1233q6	115	7	[	[	-LRB-
cord-326228-9x1233q6	115	8	44	44	CD
cord-326228-9x1233q6	115	9	]	]	-RRB-
cord-326228-9x1233q6	115	10	[	[	-LRB-
cord-326228-9x1233q6	115	11	45	45	CD
cord-326228-9x1233q6	115	12	]	]	-RRB-
cord-326228-9x1233q6	116	1	[	[	-LRB-
cord-326228-9x1233q6	116	2	46	46	CD
cord-326228-9x1233q6	116	3	]	]	-RRB-
cord-326228-9x1233q6	117	1	[	[	-LRB-
cord-326228-9x1233q6	117	2	47	47	CD
cord-326228-9x1233q6	117	3	]	]	-RRB-
cord-326228-9x1233q6	117	4	while	while	IN
cord-326228-9x1233q6	117	5	HBV	HBV	NNP
cord-326228-9x1233q6	117	6	suppresses	suppress	VBZ
cord-326228-9x1233q6	117	7	NLRP3	nlrp3	NN
cord-326228-9x1233q6	117	8	activation	activation	NN
cord-326228-9x1233q6	117	9	by	by	IN
cord-326228-9x1233q6	117	10	inhibiting	inhibit	VBG
cord-326228-9x1233q6	117	11	NF	nf	NN
cord-326228-9x1233q6	117	12	-	-	HYPH
cord-326228-9x1233q6	117	13	jB	jb	NN
cord-326228-9x1233q6	118	1	and	and	CC
cord-326228-9x1233q6	118	2	the	the	DT
cord-326228-9x1233q6	118	3	generation	generation	NN
cord-326228-9x1233q6	118	4	of	of	IN
cord-326228-9x1233q6	118	5	ROS	ROS	NNP
cord-326228-9x1233q6	118	6	.	.	.
cord-326228-9x1233q6	119	1	48	48	CD
cord-326228-9x1233q6	119	2	MFN2	MFN2	NNP
cord-326228-9x1233q6	119	3	,	,	,
cord-326228-9x1233q6	119	4	part	part	NN
cord-326228-9x1233q6	119	5	of	of	IN
cord-326228-9x1233q6	119	6	the	the	DT
cord-326228-9x1233q6	119	7	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	119	8	fusion	fusion	NN
cord-326228-9x1233q6	119	9	machinery	machinery	NN
cord-326228-9x1233q6	119	10	,	,	,
cord-326228-9x1233q6	119	11	associates	associate	NNS
cord-326228-9x1233q6	119	12	with	with	IN
cord-326228-9x1233q6	119	13	NLRP3	nlrp3	NN
cord-326228-9x1233q6	119	14	in	in	IN
cord-326228-9x1233q6	119	15	LPS	LPS	NNP
cord-326228-9x1233q6	119	16	-	-	HYPH
cord-326228-9x1233q6	119	17	primed	prime	VBN
cord-326228-9x1233q6	119	18	bone	bone	NN
cord-326228-9x1233q6	119	19	marrow	marrow	NN
cord-326228-9x1233q6	119	20	-	-	HYPH
cord-326228-9x1233q6	119	21	derived	derive	VBN
cord-326228-9x1233q6	119	22	macrophages	macrophage	NNS
cord-326228-9x1233q6	119	23	(	(	-LRB-
cord-326228-9x1233q6	119	24	BMDMs	bmdms	NN
cord-326228-9x1233q6	119	25	)	)	-RRB-
cord-326228-9x1233q6	119	26	upon	upon	IN
cord-326228-9x1233q6	119	27	infection	infection	NN
cord-326228-9x1233q6	119	28	with	with	IN
cord-326228-9x1233q6	119	29	influenza	influenza	NN
cord-326228-9x1233q6	119	30	A	a	NN
cord-326228-9x1233q6	119	31	or	or	CC
cord-326228-9x1233q6	119	32	EMCV	EMCV	NNP
cord-326228-9x1233q6	119	33	.	.	.
cord-326228-9x1233q6	120	1	45	45	CD
cord-326228-9x1233q6	120	2	mtROS	mtros	DT
cord-326228-9x1233q6	120	3	is	be	VBZ
cord-326228-9x1233q6	120	4	also	also	RB
cord-326228-9x1233q6	120	5	crucial	crucial	JJ
cord-326228-9x1233q6	120	6	for	for	IN
cord-326228-9x1233q6	120	7	NLRP3	nlrp3	NN
cord-326228-9x1233q6	120	8	activation	activation	NN
cord-326228-9x1233q6	120	9	during	during	IN
cord-326228-9x1233q6	120	10	influenza	influenza	NN
cord-326228-9x1233q6	120	11	A	a	DT
cord-326228-9x1233q6	120	12	infection	infection	NN
cord-326228-9x1233q6	120	13	in	in	IN
cord-326228-9x1233q6	120	14	mouse	mouse	NN
cord-326228-9x1233q6	120	15	BMDMs	bmdm	NNS
cord-326228-9x1233q6	120	16	and	and	CC
cord-326228-9x1233q6	120	17	human	human	JJ
cord-326228-9x1233q6	120	18	peripheral	peripheral	JJ
cord-326228-9x1233q6	120	19	blood	blood	NN
cord-326228-9x1233q6	120	20	mononuclear	mononuclear	NN
cord-326228-9x1233q6	120	21	cells	cell	NNS
cord-326228-9x1233q6	120	22	(	(	-LRB-
cord-326228-9x1233q6	120	23	PBMCs	pbmc	NNS
cord-326228-9x1233q6	120	24	)	)	-RRB-
cord-326228-9x1233q6	120	25	.	.	.
cord-326228-9x1233q6	121	1	49	49	CD
cord-326228-9x1233q6	122	1	There	there	EX
cord-326228-9x1233q6	122	2	are	be	VBP
cord-326228-9x1233q6	122	3	conflicting	conflict	VBG
cord-326228-9x1233q6	122	4	reports	report	NNS
cord-326228-9x1233q6	122	5	regarding	regard	VBG
cord-326228-9x1233q6	122	6	the	the	DT
cord-326228-9x1233q6	122	7	requirement	requirement	NN
cord-326228-9x1233q6	122	8	for	for	IN
cord-326228-9x1233q6	122	9	DRP1dependent	DRP1dependent	NNP
cord-326228-9x1233q6	122	10	fission	fission	NN
cord-326228-9x1233q6	122	11	for	for	IN
cord-326228-9x1233q6	122	12	NLRP3	nlrp3	NN
cord-326228-9x1233q6	122	13	activation	activation	NN
cord-326228-9x1233q6	122	14	during	during	IN
cord-326228-9x1233q6	122	15	VSV	VSV	NNP
cord-326228-9x1233q6	122	16	infection	infection	NN
cord-326228-9x1233q6	122	17	.	.	.
cord-326228-9x1233q6	123	1	46	46	CD
cord-326228-9x1233q6	123	2	,	,	,
cord-326228-9x1233q6	123	3	50	50	CD
cord-326228-9x1233q6	123	4	Inhibition	inhibition	NN
cord-326228-9x1233q6	123	5	of	of	IN
cord-326228-9x1233q6	123	6	mitophagy	mitophagy	NNS
cord-326228-9x1233q6	123	7	because	because	IN
cord-326228-9x1233q6	123	8	of	of	IN
cord-326228-9x1233q6	123	9	parkin	parkin	NN
cord-326228-9x1233q6	123	10	deficiency	deficiency	NN
cord-326228-9x1233q6	123	11	enhanced	enhance	VBD
cord-326228-9x1233q6	123	12	virusinduced	virusinduce	VBD
cord-326228-9x1233q6	123	13	IL-1b/18	il-1b/18	PRP$
cord-326228-9x1233q6	123	14	secretion	secretion	NN
cord-326228-9x1233q6	123	15	during	during	IN
cord-326228-9x1233q6	123	16	VSV	VSV	NNP
cord-326228-9x1233q6	123	17	and	and	CC
cord-326228-9x1233q6	123	18	HSV-1	HSV-1	NNP
cord-326228-9x1233q6	123	19	infection	infection	NN
cord-326228-9x1233q6	123	20	.	.	.
cord-326228-9x1233q6	124	1	47	47	CD
cord-326228-9x1233q6	124	2	Mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	124	3	dynamics	dynamic	NNS
cord-326228-9x1233q6	124	4	during	during	IN
cord-326228-9x1233q6	124	5	viral	viral	JJ
cord-326228-9x1233q6	124	6	infection	infection	NN
cord-326228-9x1233q6	124	7	and	and	CC
cord-326228-9x1233q6	124	8	their	-PRON-	PRP$
cord-326228-9x1233q6	124	9	consequences	consequence	NNS
cord-326228-9x1233q6	124	10	for	for	IN
cord-326228-9x1233q6	124	11	NLRP3dependent	NLRP3dependent	NNP
cord-326228-9x1233q6	124	12	detection	detection	NN
cord-326228-9x1233q6	124	13	are	be	VBP
cord-326228-9x1233q6	124	14	varied	varied	JJ
cord-326228-9x1233q6	124	15	and	and	CC
cord-326228-9x1233q6	124	16	complex	complex	JJ
cord-326228-9x1233q6	124	17	,	,	,
cord-326228-9x1233q6	124	18	highlighting	highlight	VBG
cord-326228-9x1233q6	124	19	a	a	DT
cord-326228-9x1233q6	124	20	poorly	poorly	RB
cord-326228-9x1233q6	124	21	understood	understand	VBN
cord-326228-9x1233q6	124	22	yet	yet	CC
cord-326228-9x1233q6	124	23	intriguing	intriguing	JJ
cord-326228-9x1233q6	124	24	research	research	NN
cord-326228-9x1233q6	124	25	area	area	NN
cord-326228-9x1233q6	124	26	within	within	IN
cord-326228-9x1233q6	124	27	the	the	DT
cord-326228-9x1233q6	124	28	host	host	NN
cord-326228-9x1233q6	124	29	-	-	HYPH
cord-326228-9x1233q6	124	30	pathogen	pathogen	NN
cord-326228-9x1233q6	124	31	evolutionary	evolutionary	JJ
cord-326228-9x1233q6	124	32	arms	arm	NNS
cord-326228-9x1233q6	124	33	race	race	NN
cord-326228-9x1233q6	124	34	.	.	.
cord-326228-9x1233q6	125	1	Bacteria	Bacteria	NNS
cord-326228-9x1233q6	125	2	also	also	RB
cord-326228-9x1233q6	125	3	modulate	modulate	VBP
cord-326228-9x1233q6	125	4	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	125	5	function	function	NN
cord-326228-9x1233q6	125	6	to	to	TO
cord-326228-9x1233q6	125	7	create	create	VB
cord-326228-9x1233q6	125	8	favorable	favorable	JJ
cord-326228-9x1233q6	125	9	environments	environment	NNS
cord-326228-9x1233q6	125	10	for	for	IN
cord-326228-9x1233q6	125	11	intracellular	intracellular	JJ
cord-326228-9x1233q6	125	12	replication	replication	NN
cord-326228-9x1233q6	125	13	,	,	,
cord-326228-9x1233q6	125	14	or	or	CC
cord-326228-9x1233q6	125	15	to	to	TO
cord-326228-9x1233q6	125	16	evade	evade	VB
cord-326228-9x1233q6	125	17	host	host	NN
cord-326228-9x1233q6	125	18	innate	innate	JJ
cord-326228-9x1233q6	125	19	immune	immune	NN
cord-326228-9x1233q6	125	20	While	while	IN
cord-326228-9x1233q6	125	21	mechanisms	mechanism	NNS
cord-326228-9x1233q6	125	22	controlling	control	VBG
cord-326228-9x1233q6	125	23	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	125	24	fission	fission	NN
cord-326228-9x1233q6	125	25	and	and	CC
cord-326228-9x1233q6	125	26	fusion	fusion	NN
cord-326228-9x1233q6	125	27	are	be	VBP
cord-326228-9x1233q6	125	28	not	not	RB
cord-326228-9x1233q6	125	29	fully	fully	RB
cord-326228-9x1233q6	125	30	characterised	characterise	VBN
cord-326228-9x1233q6	125	31	,	,	,
cord-326228-9x1233q6	125	32	several	several	JJ
cord-326228-9x1233q6	125	33	key	key	JJ
cord-326228-9x1233q6	125	34	proteins	protein	NNS
cord-326228-9x1233q6	125	35	exert	exert	VBP
cord-326228-9x1233q6	125	36	key	key	JJ
cord-326228-9x1233q6	125	37	functions	function	NNS
cord-326228-9x1233q6	125	38	in	in	IN
cord-326228-9x1233q6	125	39	these	these	DT
cord-326228-9x1233q6	125	40	processes	process	NNS
cord-326228-9x1233q6	125	41	.	.	.
cord-326228-9x1233q6	126	1	Upper	upper	JJ
cord-326228-9x1233q6	126	2	:	:	:
cord-326228-9x1233q6	127	1	Fission	fission	NN
cord-326228-9x1233q6	127	2	of	of	IN
cord-326228-9x1233q6	127	3	an	an	DT
cord-326228-9x1233q6	127	4	individual	individual	JJ
cord-326228-9x1233q6	127	5	mitochondrion	mitochondrion	NN
cord-326228-9x1233q6	127	6	from	from	IN
cord-326228-9x1233q6	127	7	the	the	DT
cord-326228-9x1233q6	127	8	network	network	NN
cord-326228-9x1233q6	127	9	is	be	VBZ
cord-326228-9x1233q6	127	10	mediated	mediate	VBN
cord-326228-9x1233q6	127	11	by	by	IN
cord-326228-9x1233q6	127	12	the	the	DT
cord-326228-9x1233q6	127	13	GTPase	GTPase	NNP
cord-326228-9x1233q6	127	14	DRP1	DRP1	NNP
cord-326228-9x1233q6	127	15	,	,	,
cord-326228-9x1233q6	127	16	which	which	WDT
cord-326228-9x1233q6	127	17	operates	operate	VBZ
cord-326228-9x1233q6	127	18	in	in	IN
cord-326228-9x1233q6	127	19	a	a	DT
cord-326228-9x1233q6	127	20	'	'	``
cord-326228-9x1233q6	127	21	kiss	kiss	NN
cord-326228-9x1233q6	127	22	and	and	CC
cord-326228-9x1233q6	127	23	run	run	VBP
cord-326228-9x1233q6	127	24	'	'	''
cord-326228-9x1233q6	127	25	manner	manner	NN
cord-326228-9x1233q6	127	26	.	.	.
cord-326228-9x1233q6	128	1	Asymmetric	asymmetric	JJ
cord-326228-9x1233q6	128	2	fission	fission	NN
cord-326228-9x1233q6	128	3	is	be	VBZ
cord-326228-9x1233q6	128	4	driven	drive	VBN
cord-326228-9x1233q6	128	5	by	by	IN
cord-326228-9x1233q6	128	6	changes	change	NNS
cord-326228-9x1233q6	128	7	in	in	IN
cord-326228-9x1233q6	128	8	metabolism	metabolism	NN
cord-326228-9x1233q6	128	9	,	,	,
cord-326228-9x1233q6	128	10	damage	damage	NN
cord-326228-9x1233q6	128	11	,	,	,
cord-326228-9x1233q6	128	12	mitotic	mitotic	JJ
cord-326228-9x1233q6	128	13	division	division	NN
cord-326228-9x1233q6	128	14	or	or	CC
cord-326228-9x1233q6	128	15	infection	infection	NN
cord-326228-9x1233q6	128	16	by	by	IN
cord-326228-9x1233q6	128	17	specific	specific	JJ
cord-326228-9x1233q6	128	18	viral	viral	JJ
cord-326228-9x1233q6	128	19	and	and	CC
cord-326228-9x1233q6	128	20	bacterial	bacterial	JJ
cord-326228-9x1233q6	128	21	agents	agent	NNS
cord-326228-9x1233q6	128	22	,	,	,
cord-326228-9x1233q6	128	23	and	and	CC
cord-326228-9x1233q6	128	24	occurs	occur	VBZ
cord-326228-9x1233q6	128	25	when	when	WRB
cord-326228-9x1233q6	128	26	DRP1	DRP1	NNP
cord-326228-9x1233q6	128	27	oligomerises	oligomerise	NNS
cord-326228-9x1233q6	128	28	on	on	IN
cord-326228-9x1233q6	128	29	the	the	DT
cord-326228-9x1233q6	128	30	outer	outer	JJ
cord-326228-9x1233q6	128	31	membrane	membrane	NN
cord-326228-9x1233q6	128	32	and	and	CC
cord-326228-9x1233q6	128	33	coils	coil	NNS
cord-326228-9x1233q6	128	34	around	around	IN
cord-326228-9x1233q6	128	35	the	the	DT
cord-326228-9x1233q6	128	36	section	section	NN
cord-326228-9x1233q6	128	37	to	to	TO
cord-326228-9x1233q6	128	38	be	be	VB
cord-326228-9x1233q6	128	39	'	'	``
cord-326228-9x1233q6	128	40	pinched	pinch	VBN
cord-326228-9x1233q6	128	41	'	'	''
cord-326228-9x1233q6	128	42	off	off	RB
cord-326228-9x1233q6	128	43	.	.	.
cord-326228-9x1233q6	129	1	In	in	IN
cord-326228-9x1233q6	129	2	a	a	DT
cord-326228-9x1233q6	129	3	parallel	parallel	JJ
cord-326228-9x1233q6	129	4	fission	fission	NN
cord-326228-9x1233q6	129	5	process	process	NN
cord-326228-9x1233q6	129	6	,	,	,
cord-326228-9x1233q6	129	7	OPA1	OPA1	NNP
cord-326228-9x1233q6	129	8	is	be	VBZ
cord-326228-9x1233q6	129	9	downregulated	downregulate	VBN
cord-326228-9x1233q6	129	10	at	at	IN
cord-326228-9x1233q6	129	11	the	the	DT
cord-326228-9x1233q6	129	12	inner	inner	JJ
cord-326228-9x1233q6	129	13	membrane	membrane	NN
cord-326228-9x1233q6	129	14	portions	portion	NNS
cord-326228-9x1233q6	129	15	targeted	target	VBN
cord-326228-9x1233q6	129	16	for	for	IN
cord-326228-9x1233q6	129	17	fission	fission	NN
cord-326228-9x1233q6	129	18	.	.	.
cord-326228-9x1233q6	130	1	It	-PRON-	PRP
cord-326228-9x1233q6	130	2	is	be	VBZ
cord-326228-9x1233q6	130	3	currently	currently	RB
cord-326228-9x1233q6	130	4	unclear	unclear	JJ
cord-326228-9x1233q6	130	5	whether	whether	IN
cord-326228-9x1233q6	130	6	DRP1-mediated	drp1-mediated	JJ
cord-326228-9x1233q6	130	7	outer	outer	JJ
cord-326228-9x1233q6	130	8	membrane	membrane	NN
cord-326228-9x1233q6	130	9	fission	fission	NN
cord-326228-9x1233q6	130	10	occurs	occur	VBZ
cord-326228-9x1233q6	130	11	at	at	IN
cord-326228-9x1233q6	130	12	sites	site	NNS
cord-326228-9x1233q6	130	13	where	where	WRB
cord-326228-9x1233q6	130	14	the	the	DT
cord-326228-9x1233q6	130	15	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	130	16	matrix	matrix	NN
cord-326228-9x1233q6	130	17	is	be	VBZ
cord-326228-9x1233q6	130	18	already	already	RB
cord-326228-9x1233q6	130	19	separated	separate	VBN
cord-326228-9x1233q6	130	20	(	(	-LRB-
cord-326228-9x1233q6	130	21	as	as	IN
cord-326228-9x1233q6	130	22	shown	show	VBN
cord-326228-9x1233q6	130	23	above	above	RB
cord-326228-9x1233q6	130	24	)	)	-RRB-
cord-326228-9x1233q6	130	25	,	,	,
cord-326228-9x1233q6	130	26	or	or	CC
cord-326228-9x1233q6	130	27	requires	require	VBZ
cord-326228-9x1233q6	130	28	the	the	DT
cord-326228-9x1233q6	130	29	inner	inner	JJ
cord-326228-9x1233q6	130	30	membrane	membrane	NN
cord-326228-9x1233q6	130	31	to	to	TO
cord-326228-9x1233q6	130	32	be	be	VB
cord-326228-9x1233q6	130	33	pinched	pinch	VBN
cord-326228-9x1233q6	130	34	off	off	RP
cord-326228-9x1233q6	130	35	in	in	IN
cord-326228-9x1233q6	130	36	a	a	DT
cord-326228-9x1233q6	130	37	manner	manner	NN
cord-326228-9x1233q6	130	38	similar	similar	JJ
cord-326228-9x1233q6	130	39	to	to	IN
cord-326228-9x1233q6	130	40	the	the	DT
cord-326228-9x1233q6	130	41	outer	outer	JJ
cord-326228-9x1233q6	130	42	membrane	membrane	NN
cord-326228-9x1233q6	130	43	.	.	.
cord-326228-9x1233q6	131	1	If	if	IN
cord-326228-9x1233q6	131	2	the	the	DT
cord-326228-9x1233q6	131	3	mitochondrion	mitochondrion	NN
cord-326228-9x1233q6	131	4	is	be	VBZ
cord-326228-9x1233q6	131	5	damaged	damage	VBN
cord-326228-9x1233q6	131	6	,	,	,
cord-326228-9x1233q6	131	7	it	-PRON-	PRP
cord-326228-9x1233q6	131	8	is	be	VBZ
cord-326228-9x1233q6	131	9	degraded	degrade	VBN
cord-326228-9x1233q6	131	10	by	by	IN
cord-326228-9x1233q6	131	11	mitophagy	mitophagy	NNS
cord-326228-9x1233q6	131	12	.	.	.
cord-326228-9x1233q6	132	1	Lower	lower	JJ
cord-326228-9x1233q6	132	2	:	:	:
cord-326228-9x1233q6	132	3	Fusion	fusion	NN
cord-326228-9x1233q6	132	4	counters	counter	NNS
cord-326228-9x1233q6	132	5	fission	fission	NN
cord-326228-9x1233q6	132	6	.	.	.
cord-326228-9x1233q6	133	1	An	an	DT
cord-326228-9x1233q6	133	2	individual	individual	JJ
cord-326228-9x1233q6	133	3	mitochondrion	mitochondrion	NN
cord-326228-9x1233q6	133	4	'	'	``
cord-326228-9x1233q6	133	5	docks	dock	NNS
cord-326228-9x1233q6	133	6	'	'	''
cord-326228-9x1233q6	133	7	to	to	IN
cord-326228-9x1233q6	133	8	the	the	DT
cord-326228-9x1233q6	133	9	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	133	10	network	network	NN
cord-326228-9x1233q6	133	11	via	via	IN
cord-326228-9x1233q6	133	12	MFN1	MFN1	NNP
cord-326228-9x1233q6	133	13	and	and	CC
cord-326228-9x1233q6	133	14	MFN2	MFN2	NNP
cord-326228-9x1233q6	133	15	,	,	,
cord-326228-9x1233q6	133	16	which	which	WDT
cord-326228-9x1233q6	133	17	anchor	anchor	VBD
cord-326228-9x1233q6	133	18	the	the	DT
cord-326228-9x1233q6	133	19	opposing	oppose	VBG
cord-326228-9x1233q6	133	20	outer	outer	JJ
cord-326228-9x1233q6	133	21	membranes	membrane	NNS
cord-326228-9x1233q6	133	22	and	and	CC
cord-326228-9x1233q6	133	23	shape	shape	VB
cord-326228-9x1233q6	133	24	the	the	DT
cord-326228-9x1233q6	133	25	lipid	lipid	NN
cord-326228-9x1233q6	133	26	bilayer	bilayer	NN
cord-326228-9x1233q6	133	27	into	into	IN
cord-326228-9x1233q6	133	28	extreme	extreme	JJ
cord-326228-9x1233q6	133	29	curvature	curvature	NN
cord-326228-9x1233q6	133	30	.	.	.
cord-326228-9x1233q6	134	1	The	the	DT
cord-326228-9x1233q6	134	2	membranes	membrane	NNS
cord-326228-9x1233q6	134	3	are	be	VBP
cord-326228-9x1233q6	134	4	forced	force	VBN
cord-326228-9x1233q6	134	5	to	to	TO
cord-326228-9x1233q6	134	6	create	create	VB
cord-326228-9x1233q6	134	7	a	a	DT
cord-326228-9x1233q6	134	8	bridge	bridge	NN
cord-326228-9x1233q6	134	9	and	and	CC
cord-326228-9x1233q6	134	10	eventually	eventually	RB
cord-326228-9x1233q6	134	11	reincorporate	reincorporate	VB
cord-326228-9x1233q6	134	12	the	the	DT
cord-326228-9x1233q6	134	13	mitochondrion	mitochondrion	NN
cord-326228-9x1233q6	134	14	back	back	RB
cord-326228-9x1233q6	134	15	into	into	IN
cord-326228-9x1233q6	134	16	the	the	DT
cord-326228-9x1233q6	134	17	network	network	NN
cord-326228-9x1233q6	134	18	,	,	,
cord-326228-9x1233q6	134	19	where	where	WRB
cord-326228-9x1233q6	134	20	,	,	,
cord-326228-9x1233q6	134	21	presumably	presumably	RB
cord-326228-9x1233q6	134	22	,	,	,
cord-326228-9x1233q6	134	23	OPA1	OPA1	NNP
cord-326228-9x1233q6	134	24	reattaches	reattache	NNS
cord-326228-9x1233q6	134	25	between	between	IN
cord-326228-9x1233q6	134	26	the	the	DT
cord-326228-9x1233q6	134	27	inner	inner	JJ
cord-326228-9x1233q6	134	28	membranes	membrane	NNS
cord-326228-9x1233q6	134	29	to	to	TO
cord-326228-9x1233q6	134	30	support	support	VB
cord-326228-9x1233q6	134	31	these	these	DT
cord-326228-9x1233q6	134	32	as	as	IN
cord-326228-9x1233q6	134	33	discrete	discrete	JJ
cord-326228-9x1233q6	134	34	compartments	compartment	NNS
cord-326228-9x1233q6	134	35	.	.	.
cord-326228-9x1233q6	135	1	It	-PRON-	PRP
cord-326228-9x1233q6	135	2	is	be	VBZ
cord-326228-9x1233q6	135	3	currently	currently	RB
cord-326228-9x1233q6	135	4	unclear	unclear	JJ
cord-326228-9x1233q6	135	5	whether	whether	IN
cord-326228-9x1233q6	135	6	OPA1	opa1	JJ
cord-326228-9x1233q6	135	7	drives	drive	NNS
cord-326228-9x1233q6	135	8	true	true	JJ
cord-326228-9x1233q6	135	9	fusion	fusion	NN
cord-326228-9x1233q6	135	10	of	of	IN
cord-326228-9x1233q6	135	11	the	the	DT
cord-326228-9x1233q6	135	12	inner	inner	JJ
cord-326228-9x1233q6	135	13	membranes	membrane	NNS
cord-326228-9x1233q6	135	14	as	as	IN
cord-326228-9x1233q6	135	15	DRP1	DRP1	NNP
cord-326228-9x1233q6	135	16	does	do	VBZ
cord-326228-9x1233q6	135	17	for	for	IN
cord-326228-9x1233q6	135	18	the	the	DT
cord-326228-9x1233q6	135	19	outer	outer	JJ
cord-326228-9x1233q6	135	20	membrane	membrane	NN
cord-326228-9x1233q6	135	21	,	,	,
cord-326228-9x1233q6	135	22	or	or	CC
cord-326228-9x1233q6	135	23	if	if	IN
cord-326228-9x1233q6	135	24	it	-PRON-	PRP
cord-326228-9x1233q6	135	25	anchors	anchor	VBZ
cord-326228-9x1233q6	135	26	two	two	CD
cord-326228-9x1233q6	135	27	discrete	discrete	JJ
cord-326228-9x1233q6	135	28	matrix	matrix	NN
cord-326228-9x1233q6	135	29	compartments	compartment	NNS
cord-326228-9x1233q6	135	30	to	to	IN
cord-326228-9x1233q6	135	31	one	one	CD
cord-326228-9x1233q6	135	32	another	another	DT
cord-326228-9x1233q6	135	33	.	.	.
cord-326228-9x1233q6	136	1	Fusion	fusion	NN
cord-326228-9x1233q6	136	2	is	be	VBZ
cord-326228-9x1233q6	136	3	presumed	presume	VBN
cord-326228-9x1233q6	136	4	to	to	TO
cord-326228-9x1233q6	136	5	allow	allow	VB
cord-326228-9x1233q6	136	6	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	136	7	to	to	TO
cord-326228-9x1233q6	136	8	maintain	maintain	VB
cord-326228-9x1233q6	136	9	an	an	DT
cord-326228-9x1233q6	136	10	even	even	JJ
cord-326228-9x1233q6	136	11	distribution	distribution	NN
cord-326228-9x1233q6	136	12	of	of	IN
cord-326228-9x1233q6	136	13	matrix	matrix	NN
cord-326228-9x1233q6	136	14	components	component	NNS
cord-326228-9x1233q6	136	15	across	across	IN
cord-326228-9x1233q6	136	16	the	the	DT
cord-326228-9x1233q6	136	17	network	network	NN
cord-326228-9x1233q6	136	18	and	and	CC
cord-326228-9x1233q6	136	19	may	may	MD
cord-326228-9x1233q6	136	20	also	also	RB
cord-326228-9x1233q6	136	21	be	be	VB
cord-326228-9x1233q6	136	22	reparative	reparative	JJ
cord-326228-9x1233q6	136	23	.	.	.
cord-326228-9x1233q6	137	1	Fusion	fusion	NN
cord-326228-9x1233q6	137	2	is	be	VBZ
cord-326228-9x1233q6	137	3	promoted	promote	VBN
cord-326228-9x1233q6	137	4	by	by	IN
cord-326228-9x1233q6	137	5	cell	cell	NN
cord-326228-9x1233q6	137	6	infection	infection	NN
cord-326228-9x1233q6	137	7	with	with	IN
cord-326228-9x1233q6	137	8	specific	specific	JJ
cord-326228-9x1233q6	137	9	viruses	virus	NNS
cord-326228-9x1233q6	137	10	.	.	.
cord-326228-9x1233q6	138	1	recognition	recognition	NNP
cord-326228-9x1233q6	138	2	.	.	.
cord-326228-9x1233q6	139	1	51	51	CD
cord-326228-9x1233q6	140	1	Here	here	RB
cord-326228-9x1233q6	140	2	,	,	,
cord-326228-9x1233q6	140	3	we	-PRON-	PRP
cord-326228-9x1233q6	140	4	focus	focus	VBP
cord-326228-9x1233q6	140	5	on	on	IN
cord-326228-9x1233q6	140	6	those	those	DT
cord-326228-9x1233q6	140	7	bacteria	bacteria	NNS
cord-326228-9x1233q6	140	8	that	that	WDT
cord-326228-9x1233q6	140	9	affect	affect	VBP
cord-326228-9x1233q6	140	10	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	140	11	morphology	morphology	NN
cord-326228-9x1233q6	140	12	,	,	,
cord-326228-9x1233q6	140	13	and	and	CC
cord-326228-9x1233q6	140	14	speculate	speculate	VB
cord-326228-9x1233q6	140	15	as	as	IN
cord-326228-9x1233q6	140	16	to	to	IN
cord-326228-9x1233q6	140	17	how	how	WRB
cord-326228-9x1233q6	140	18	this	this	DT
cord-326228-9x1233q6	140	19	may	may	MD
cord-326228-9x1233q6	140	20	influence	influence	VB
cord-326228-9x1233q6	140	21	inflammation	inflammation	NN
cord-326228-9x1233q6	140	22	.	.	.
cord-326228-9x1233q6	141	1	The	the	DT
cord-326228-9x1233q6	141	2	intracellular	intracellular	JJ
cord-326228-9x1233q6	141	3	pathogen	pathogen	NN
cord-326228-9x1233q6	141	4	Listeria	Listeria	NNP
cord-326228-9x1233q6	141	5	monocytogenes	monocytogenes	NN
cord-326228-9x1233q6	141	6	secretes	secrete	VBZ
cord-326228-9x1233q6	141	7	a	a	DT
cord-326228-9x1233q6	141	8	toxin	toxin	NN
cord-326228-9x1233q6	141	9	,	,	,
cord-326228-9x1233q6	141	10	listeriolysin	listeriolysin	NNP
cord-326228-9x1233q6	141	11	(	(	-LRB-
cord-326228-9x1233q6	141	12	LLO	LLO	NNP
cord-326228-9x1233q6	141	13	)	)	-RRB-
cord-326228-9x1233q6	141	14	,	,	,
cord-326228-9x1233q6	141	15	which	which	WDT
cord-326228-9x1233q6	141	16	activates	activate	VBZ
cord-326228-9x1233q6	141	17	the	the	DT
cord-326228-9x1233q6	141	18	NLRP3	nlrp3	XX
cord-326228-9x1233q6	141	19	inflammasome	inflammasome	NN
cord-326228-9x1233q6	141	20	via	via	IN
cord-326228-9x1233q6	141	21	K	k	NN
cord-326228-9x1233q6	141	22	+	+	CC
cord-326228-9x1233q6	141	23	efflux	efflux	NN
cord-326228-9x1233q6	141	24	.	.	.
cord-326228-9x1233q6	142	1	52	52	CD
cord-326228-9x1233q6	142	2	,	,	,
cord-326228-9x1233q6	142	3	53	53	CD
cord-326228-9x1233q6	142	4	LLO	LLO	NNP
cord-326228-9x1233q6	142	5	also	also	RB
cord-326228-9x1233q6	142	6	induces	induce	VBZ
cord-326228-9x1233q6	142	7	DRP1-and	DRP1-and	NNP
cord-326228-9x1233q6	142	8	OPA1independent	OPA1independent	NNP
cord-326228-9x1233q6	142	9	fission	fission	NN
cord-326228-9x1233q6	142	10	by	by	IN
cord-326228-9x1233q6	142	11	modulating	modulate	VBG
cord-326228-9x1233q6	142	12	the	the	DT
cord-326228-9x1233q6	142	13	membranes	membrane	NNS
cord-326228-9x1233q6	142	14	shared	share	VBN
cord-326228-9x1233q6	142	15	between	between	IN
cord-326228-9x1233q6	142	16	the	the	DT
cord-326228-9x1233q6	142	17	ER	ER	NNP
cord-326228-9x1233q6	142	18	and	and	CC
cord-326228-9x1233q6	142	19	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	142	20	(	(	-LRB-
cord-326228-9x1233q6	142	21	MAMs	MAMs	NNP
cord-326228-9x1233q6	142	22	)	)	-RRB-
cord-326228-9x1233q6	142	23	,	,	,
cord-326228-9x1233q6	142	24	54	54	CD
cord-326228-9x1233q6	142	25	hinting	hint	VBG
cord-326228-9x1233q6	142	26	at	at	IN
cord-326228-9x1233q6	142	27	a	a	DT
cord-326228-9x1233q6	142	28	novel	novel	JJ
cord-326228-9x1233q6	142	29	ERdependent	erdependent	JJ
cord-326228-9x1233q6	142	30	fission	fission	NN
cord-326228-9x1233q6	142	31	mechanism	mechanism	NN
cord-326228-9x1233q6	142	32	.	.	.
cord-326228-9x1233q6	143	1	MAMs	mam	NNS
cord-326228-9x1233q6	143	2	are	be	VBP
cord-326228-9x1233q6	143	3	emerging	emerge	VBG
cord-326228-9x1233q6	143	4	as	as	IN
cord-326228-9x1233q6	143	5	important	important	JJ
cord-326228-9x1233q6	143	6	signalling	signal	VBG
cord-326228-9x1233q6	143	7	hubs	hub	NNS
cord-326228-9x1233q6	143	8	between	between	IN
cord-326228-9x1233q6	143	9	the	the	DT
cord-326228-9x1233q6	143	10	ER	er	NN
cord-326228-9x1233q6	143	11	and	and	CC
cord-326228-9x1233q6	143	12	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	143	13	and	and	CC
cord-326228-9x1233q6	143	14	are	be	VBP
cord-326228-9x1233q6	143	15	a	a	DT
cord-326228-9x1233q6	143	16	possible	possible	JJ
cord-326228-9x1233q6	143	17	site	site	NN
cord-326228-9x1233q6	143	18	of	of	IN
cord-326228-9x1233q6	143	19	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	143	20	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	143	21	assembly	assembly	NNP
cord-326228-9x1233q6	143	22	.	.	.
cord-326228-9x1233q6	144	1	55	55	CD
cord-326228-9x1233q6	145	1	It	-PRON-	PRP
cord-326228-9x1233q6	145	2	is	be	VBZ
cord-326228-9x1233q6	145	3	possible	possible	JJ
cord-326228-9x1233q6	145	4	that	that	IN
cord-326228-9x1233q6	145	5	LLO	LLO	NNP
cord-326228-9x1233q6	145	6	-	-	HYPH
cord-326228-9x1233q6	145	7	driven	drive	VBN
cord-326228-9x1233q6	145	8	MAM	MAM	NNP
cord-326228-9x1233q6	145	9	disruption	disruption	NN
cord-326228-9x1233q6	145	10	and	and	CC
cord-326228-9x1233q6	145	11	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	145	12	fission	fission	NN
cord-326228-9x1233q6	145	13	removes	remove	VBZ
cord-326228-9x1233q6	145	14	a	a	DT
cord-326228-9x1233q6	145	15	key	key	JJ
cord-326228-9x1233q6	145	16	site	site	NN
cord-326228-9x1233q6	145	17	of	of	IN
cord-326228-9x1233q6	145	18	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	145	19	assembly	assembly	NNP
cord-326228-9x1233q6	145	20	to	to	TO
cord-326228-9x1233q6	145	21	dampen	dampen	VB
cord-326228-9x1233q6	145	22	K	K	NNP
cord-326228-9x1233q6	145	23	+	+	CC
cord-326228-9x1233q6	145	24	effluxdependent	effluxdependent	NN
cord-326228-9x1233q6	145	25	NLRP3	nlrp3	NN
cord-326228-9x1233q6	145	26	signalling	signal	VBG
cord-326228-9x1233q6	145	27	and	and	CC
cord-326228-9x1233q6	145	28	thereby	thereby	RB
cord-326228-9x1233q6	145	29	allows	allow	VBZ
cord-326228-9x1233q6	145	30	the	the	DT
cord-326228-9x1233q6	145	31	bacterium	bacterium	NN
cord-326228-9x1233q6	145	32	to	to	TO
cord-326228-9x1233q6	145	33	partially	partially	RB
cord-326228-9x1233q6	145	34	evade	evade	VB
cord-326228-9x1233q6	145	35	immune	immune	JJ
cord-326228-9x1233q6	145	36	recognition	recognition	NN
cord-326228-9x1233q6	145	37	.	.	.
cord-326228-9x1233q6	146	1	Another	another	DT
cord-326228-9x1233q6	146	2	intracellular	intracellular	JJ
cord-326228-9x1233q6	146	3	bacterial	bacterial	JJ
cord-326228-9x1233q6	146	4	parasite	parasite	NN
cord-326228-9x1233q6	146	5	,	,	,
cord-326228-9x1233q6	146	6	Legionella	Legionella	NNP
cord-326228-9x1233q6	146	7	pneumophila	pneumophila	NN
cord-326228-9x1233q6	146	8	,	,	,
cord-326228-9x1233q6	146	9	secretes	secrete	VBZ
cord-326228-9x1233q6	146	10	the	the	DT
cord-326228-9x1233q6	146	11	toxin	toxin	NN
cord-326228-9x1233q6	146	12	MitF	MitF	NNP
cord-326228-9x1233q6	146	13	to	to	TO
cord-326228-9x1233q6	146	14	upregulate	upregulate	VB
cord-326228-9x1233q6	146	15	the	the	DT
cord-326228-9x1233q6	146	16	fission	fission	NN
cord-326228-9x1233q6	146	17	agent	agent	NN
cord-326228-9x1233q6	146	18	DRP1	DRP1	NNP
cord-326228-9x1233q6	146	19	at	at	IN
cord-326228-9x1233q6	146	20	the	the	DT
cord-326228-9x1233q6	146	21	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	146	22	outer	outer	JJ
cord-326228-9x1233q6	146	23	membrane	membrane	NN
cord-326228-9x1233q6	146	24	.	.	.
cord-326228-9x1233q6	147	1	56	56	CD
cord-326228-9x1233q6	148	1	MitF	MitF	NNP
cord-326228-9x1233q6	148	2	thereby	thereby	RB
cord-326228-9x1233q6	148	3	induces	induce	VBZ
cord-326228-9x1233q6	148	4	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	148	5	fragmentation	fragmentation	NN
cord-326228-9x1233q6	148	6	,	,	,
cord-326228-9x1233q6	148	7	which	which	WDT
cord-326228-9x1233q6	148	8	appears	appear	VBZ
cord-326228-9x1233q6	148	9	to	to	TO
cord-326228-9x1233q6	148	10	be	be	VB
cord-326228-9x1233q6	148	11	a	a	DT
cord-326228-9x1233q6	148	12	strategy	strategy	NN
cord-326228-9x1233q6	148	13	to	to	TO
cord-326228-9x1233q6	148	14	reprogramme	reprogramme	NNP
cord-326228-9x1233q6	148	15	host	host	NN
cord-326228-9x1233q6	148	16	macrophage	macrophage	NN
cord-326228-9x1233q6	148	17	metabolism	metabolism	NN
cord-326228-9x1233q6	148	18	56	56	CD
cord-326228-9x1233q6	148	19	to	to	TO
cord-326228-9x1233q6	148	20	limit	limit	VB
cord-326228-9x1233q6	148	21	oxidative	oxidative	JJ
cord-326228-9x1233q6	148	22	phosphorylation	phosphorylation	NN
cord-326228-9x1233q6	148	23	(	(	-LRB-
cord-326228-9x1233q6	148	24	OXPHOS	OXPHOS	NNP
cord-326228-9x1233q6	148	25	)	)	-RRB-
cord-326228-9x1233q6	148	26	and	and	CC
cord-326228-9x1233q6	148	27	create	create	VB
cord-326228-9x1233q6	148	28	the	the	DT
cord-326228-9x1233q6	148	29	glycolytic	glycolytic	JJ
cord-326228-9x1233q6	148	30	environment	environment	NN
cord-326228-9x1233q6	148	31	favored	favor	VBN
cord-326228-9x1233q6	148	32	by	by	IN
cord-326228-9x1233q6	148	33	L.	L.	NNP
cord-326228-9x1233q6	148	34	pneumophila	pneumophila	NN
cord-326228-9x1233q6	148	35	.	.	.
cord-326228-9x1233q6	149	1	L.	L.	NNP
cord-326228-9x1233q6	149	2	pneumophila	pneumophila	NN
cord-326228-9x1233q6	149	3	indirectly	indirectly	RB
cord-326228-9x1233q6	149	4	activates	activate	VBZ
cord-326228-9x1233q6	149	5	NLRP3	nlrp3	XX
cord-326228-9x1233q6	149	6	through	through	IN
cord-326228-9x1233q6	149	7	the	the	DT
cord-326228-9x1233q6	149	8	caspase-11	caspase-11	NNS
cord-326228-9x1233q6	149	9	and	and	CC
cord-326228-9x1233q6	149	10	absent	absent	JJ
cord-326228-9x1233q6	149	11	in	in	IN
cord-326228-9x1233q6	149	12	melanoma	melanoma	NN
cord-326228-9x1233q6	149	13	2	2	CD
cord-326228-9x1233q6	149	14	(	(	-LRB-
cord-326228-9x1233q6	149	15	AIM2	AIM2	NNP
cord-326228-9x1233q6	149	16	)	)	-RRB-
cord-326228-9x1233q6	149	17	inflammasomes	inflammasome	NNS
cord-326228-9x1233q6	149	18	.	.	.
cord-326228-9x1233q6	150	1	57	57	CD
cord-326228-9x1233q6	150	2	,	,	,
cord-326228-9x1233q6	150	3	58	58	CD
cord-326228-9x1233q6	150	4	Bacterially	bacterially	RB
cord-326228-9x1233q6	150	5	-	-	HYPH
cord-326228-9x1233q6	150	6	induced	induce	VBN
cord-326228-9x1233q6	150	7	metabolic	metabolic	JJ
cord-326228-9x1233q6	150	8	changes	change	NNS
cord-326228-9x1233q6	150	9	may	may	MD
cord-326228-9x1233q6	150	10	also	also	RB
cord-326228-9x1233q6	150	11	indirectly	indirectly	RB
cord-326228-9x1233q6	150	12	affect	affect	VB
cord-326228-9x1233q6	150	13	NLRP3	nlrp3	NN
cord-326228-9x1233q6	150	14	activation	activation	NN
cord-326228-9x1233q6	150	15	and	and	CC
cord-326228-9x1233q6	150	16	innate	innate	JJ
cord-326228-9x1233q6	150	17	immune	immune	JJ
cord-326228-9x1233q6	150	18	function	function	NN
cord-326228-9x1233q6	150	19	more	more	RBR
cord-326228-9x1233q6	150	20	broadly	broadly	RB
cord-326228-9x1233q6	150	21	.	.	.
cord-326228-9x1233q6	151	1	Mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	151	2	are	be	VBP
cord-326228-9x1233q6	151	3	important	important	JJ
cord-326228-9x1233q6	151	4	for	for	IN
cord-326228-9x1233q6	151	5	energy	energy	NN
cord-326228-9x1233q6	151	6	production	production	NN
cord-326228-9x1233q6	151	7	,	,	,
cord-326228-9x1233q6	151	8	providing	provide	VBG
cord-326228-9x1233q6	151	9	much	much	JJ
cord-326228-9x1233q6	151	10	of	of	IN
cord-326228-9x1233q6	151	11	the	the	DT
cord-326228-9x1233q6	151	12	cellular	cellular	JJ
cord-326228-9x1233q6	151	13	pool	pool	NN
cord-326228-9x1233q6	151	14	of	of	IN
cord-326228-9x1233q6	151	15	ATP	ATP	NNP
cord-326228-9x1233q6	151	16	for	for	IN
cord-326228-9x1233q6	151	17	cellular	cellular	JJ
cord-326228-9x1233q6	151	18	functions	function	NNS
cord-326228-9x1233q6	151	19	.	.	.
cord-326228-9x1233q6	152	1	During	during	IN
cord-326228-9x1233q6	152	2	OXPHOS	OXPHOS	NNP
cord-326228-9x1233q6	152	3	,	,	,
cord-326228-9x1233q6	152	4	the	the	DT
cord-326228-9x1233q6	152	5	four	four	CD
cord-326228-9x1233q6	152	6	complexes	complex	NNS
cord-326228-9x1233q6	152	7	of	of	IN
cord-326228-9x1233q6	152	8	the	the	DT
cord-326228-9x1233q6	152	9	electron	electron	NN
cord-326228-9x1233q6	152	10	transport	transport	NN
cord-326228-9x1233q6	152	11	chain	chain	NN
cord-326228-9x1233q6	152	12	(	(	-LRB-
cord-326228-9x1233q6	152	13	ETC	etc	NN
cord-326228-9x1233q6	152	14	)	)	-RRB-
cord-326228-9x1233q6	152	15	cooperate	cooperate	VBP
cord-326228-9x1233q6	152	16	with	with	IN
cord-326228-9x1233q6	152	17	ATP	ATP	NNP
cord-326228-9x1233q6	152	18	synthase	synthase	NN
cord-326228-9x1233q6	152	19	to	to	TO
cord-326228-9x1233q6	152	20	produce	produce	VB
cord-326228-9x1233q6	152	21	ATP	ATP	NNP
cord-326228-9x1233q6	152	22	at	at	IN
cord-326228-9x1233q6	152	23	the	the	DT
cord-326228-9x1233q6	152	24	inner	inner	JJ
cord-326228-9x1233q6	152	25	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	152	26	membrane	membrane	NN
cord-326228-9x1233q6	152	27	.	.	.
cord-326228-9x1233q6	153	1	59	59	CD
cord-326228-9x1233q6	154	1	The	the	DT
cord-326228-9x1233q6	154	2	ETC	etc	FW
cord-326228-9x1233q6	154	3	generates	generate	VBZ
cord-326228-9x1233q6	154	4	a	a	DT
cord-326228-9x1233q6	154	5	proton	proton	NN
cord-326228-9x1233q6	154	6	motive	motive	NN
cord-326228-9x1233q6	154	7	force	force	NN
cord-326228-9x1233q6	154	8	that	that	WDT
cord-326228-9x1233q6	154	9	drives	drive	VBZ
cord-326228-9x1233q6	154	10	ATP	ATP	NNP
cord-326228-9x1233q6	154	11	synthase	synthase	NN
cord-326228-9x1233q6	154	12	and	and	CC
cord-326228-9x1233q6	154	13	results	result	NNS
cord-326228-9x1233q6	154	14	in	in	IN
cord-326228-9x1233q6	154	15	the	the	DT
cord-326228-9x1233q6	154	16	net	net	JJ
cord-326228-9x1233q6	154	17	production	production	NN
cord-326228-9x1233q6	154	18	of	of	IN
cord-326228-9x1233q6	154	19	34	34	CD
cord-326228-9x1233q6	154	20	ATP	ATP	NNP
cord-326228-9x1233q6	154	21	molecules	molecule	NNS
cord-326228-9x1233q6	154	22	per	per	IN
cord-326228-9x1233q6	154	23	molecule	molecule	NN
cord-326228-9x1233q6	154	24	of	of	IN
cord-326228-9x1233q6	154	25	glucose	glucose	NN
cord-326228-9x1233q6	154	26	,	,	,
cord-326228-9x1233q6	154	27	outcompeting	outcompete	VBG
cord-326228-9x1233q6	154	28	glycolysis	glycolysis	NN
cord-326228-9x1233q6	154	29	and	and	CC
cord-326228-9x1233q6	154	30	the	the	DT
cord-326228-9x1233q6	154	31	Krebs	Krebs	NNP
cord-326228-9x1233q6	154	32	cycle	cycle	NN
cord-326228-9x1233q6	154	33	(	(	-LRB-
cord-326228-9x1233q6	154	34	each	each	DT
cord-326228-9x1233q6	154	35	2	2	CD
cord-326228-9x1233q6	154	36	ATP	ATP	NNP
cord-326228-9x1233q6	154	37	molecules	molecule	NNS
cord-326228-9x1233q6	154	38	)	)	-RRB-
cord-326228-9x1233q6	154	39	for	for	IN
cord-326228-9x1233q6	154	40	the	the	DT
cord-326228-9x1233q6	154	41	efficient	efficient	JJ
cord-326228-9x1233q6	154	42	generation	generation	NN
cord-326228-9x1233q6	154	43	of	of	IN
cord-326228-9x1233q6	154	44	energy	energy	NN
cord-326228-9x1233q6	154	45	currency	currency	NN
cord-326228-9x1233q6	154	46	in	in	IN
cord-326228-9x1233q6	154	47	resting	rest	VBG
cord-326228-9x1233q6	154	48	cells	cell	NNS
cord-326228-9x1233q6	154	49	.	.	.
cord-326228-9x1233q6	155	1	Many	many	JJ
cord-326228-9x1233q6	155	2	pathogen	pathogen	NN
cord-326228-9x1233q6	155	3	-	-	HYPH
cord-326228-9x1233q6	155	4	derived	derive	VBN
cord-326228-9x1233q6	155	5	or	or	CC
cord-326228-9x1233q6	155	6	sterile	sterile	JJ
cord-326228-9x1233q6	155	7	immune	immune	JJ
cord-326228-9x1233q6	155	8	triggers	trigger	NNS
cord-326228-9x1233q6	155	9	can	can	MD
cord-326228-9x1233q6	155	10	disrupt	disrupt	VB
cord-326228-9x1233q6	155	11	the	the	DT
cord-326228-9x1233q6	155	12	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	155	13	membrane	membrane	NN
cord-326228-9x1233q6	155	14	potential	potential	NN
cord-326228-9x1233q6	155	15	leading	lead	VBG
cord-326228-9x1233q6	155	16	to	to	IN
cord-326228-9x1233q6	155	17	suppressed	suppress	VBN
cord-326228-9x1233q6	155	18	OXPHOS	OXPHOS	NNP
cord-326228-9x1233q6	155	19	,	,	,
cord-326228-9x1233q6	155	20	so	so	IN
cord-326228-9x1233q6	155	21	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	155	22	are	be	VBP
cord-326228-9x1233q6	155	23	exquisitely	exquisitely	RB
cord-326228-9x1233q6	155	24	sensitive	sensitive	JJ
cord-326228-9x1233q6	155	25	to	to	IN
cord-326228-9x1233q6	155	26	the	the	DT
cord-326228-9x1233q6	155	27	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	155	28	status	status	NN
cord-326228-9x1233q6	155	29	of	of	IN
cord-326228-9x1233q6	155	30	the	the	DT
cord-326228-9x1233q6	155	31	immune	immune	JJ
cord-326228-9x1233q6	155	32	cells	cell	NNS
cord-326228-9x1233q6	155	33	they	-PRON-	PRP
cord-326228-9x1233q6	155	34	inhabit	inhabit	VBP
cord-326228-9x1233q6	155	35	.	.	.
cord-326228-9x1233q6	156	1	The	the	DT
cord-326228-9x1233q6	156	2	emerging	emerge	VBG
cord-326228-9x1233q6	156	3	field	field	NN
cord-326228-9x1233q6	156	4	of	of	IN
cord-326228-9x1233q6	156	5	'	'	``
cord-326228-9x1233q6	156	6	immunometabolism	immunometabolism	NN
cord-326228-9x1233q6	156	7	'	'	POS
cord-326228-9x1233q6	156	8	examines	examine	VBZ
cord-326228-9x1233q6	156	9	alterations	alteration	NNS
cord-326228-9x1233q6	156	10	in	in	IN
cord-326228-9x1233q6	156	11	cell	cell	NN
cord-326228-9x1233q6	156	12	metabolism	metabolism	NN
cord-326228-9x1233q6	156	13	during	during	IN
cord-326228-9x1233q6	156	14	inflammation	inflammation	NN
cord-326228-9x1233q6	156	15	.	.	.
cord-326228-9x1233q6	157	1	60	60	CD
cord-326228-9x1233q6	158	1	Because	because	IN
cord-326228-9x1233q6	158	2	of	of	IN
cord-326228-9x1233q6	158	3	the	the	DT
cord-326228-9x1233q6	158	4	enormous	enormous	JJ
cord-326228-9x1233q6	158	5	scope	scope	NN
cord-326228-9x1233q6	158	6	of	of	IN
cord-326228-9x1233q6	158	7	immunometabolism	immunometabolism	NN
cord-326228-9x1233q6	158	8	and	and	CC
cord-326228-9x1233q6	158	9	its	-PRON-	PRP$
cord-326228-9x1233q6	158	10	pervasive	pervasive	JJ
cord-326228-9x1233q6	158	11	roles	role	NNS
cord-326228-9x1233q6	158	12	in	in	IN
cord-326228-9x1233q6	158	13	an	an	DT
cord-326228-9x1233q6	158	14	ever	ever	RB
cord-326228-9x1233q6	158	15	-	-	HYPH
cord-326228-9x1233q6	158	16	growing	grow	VBG
cord-326228-9x1233q6	158	17	list	list	NN
cord-326228-9x1233q6	158	18	of	of	IN
cord-326228-9x1233q6	158	19	immunological	immunological	JJ
cord-326228-9x1233q6	158	20	contexts	context	NNS
cord-326228-9x1233q6	158	21	,	,	,
cord-326228-9x1233q6	158	22	here	here	RB
cord-326228-9x1233q6	158	23	we	-PRON-	PRP
cord-326228-9x1233q6	158	24	specifically	specifically	RB
cord-326228-9x1233q6	158	25	focus	focus	VBP
cord-326228-9x1233q6	158	26	on	on	IN
cord-326228-9x1233q6	158	27	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	158	28	metabolic	metabolic	JJ
cord-326228-9x1233q6	158	29	fluctuations	fluctuation	NNS
cord-326228-9x1233q6	158	30	in	in	IN
cord-326228-9x1233q6	158	31	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	158	32	macrophages	macrophage	NNS
cord-326228-9x1233q6	158	33	,	,	,
cord-326228-9x1233q6	158	34	and	and	CC
cord-326228-9x1233q6	158	35	how	how	WRB
cord-326228-9x1233q6	158	36	changes	change	NNS
cord-326228-9x1233q6	158	37	in	in	IN
cord-326228-9x1233q6	158	38	cell	cell	NN
cord-326228-9x1233q6	158	39	metabolism	metabolism	NN
cord-326228-9x1233q6	158	40	influence	influence	NN
cord-326228-9x1233q6	158	41	NLRP3	nlrp3	NN
cord-326228-9x1233q6	158	42	activation	activation	NN
cord-326228-9x1233q6	158	43	.	.	.
cord-326228-9x1233q6	159	1	Macrophages	macrophage	NNS
cord-326228-9x1233q6	159	2	undergo	undergo	VBP
cord-326228-9x1233q6	159	3	metabolic	metabolic	JJ
cord-326228-9x1233q6	159	4	reprogramming	reprogramming	NN
cord-326228-9x1233q6	159	5	during	during	IN
cord-326228-9x1233q6	159	6	their	-PRON-	PRP$
cord-326228-9x1233q6	159	7	activation	activation	NN
cord-326228-9x1233q6	159	8	,	,	,
cord-326228-9x1233q6	159	9	switching	switch	VBG
cord-326228-9x1233q6	159	10	from	from	IN
cord-326228-9x1233q6	159	11	OXPHOS	OXPHOS	NNP
cord-326228-9x1233q6	159	12	to	to	IN
cord-326228-9x1233q6	159	13	glycolysis	glycolysis	NN
cord-326228-9x1233q6	159	14	as	as	IN
cord-326228-9x1233q6	159	15	the	the	DT
cord-326228-9x1233q6	159	16	primary	primary	JJ
cord-326228-9x1233q6	159	17	route	route	NN
cord-326228-9x1233q6	159	18	for	for	IN
cord-326228-9x1233q6	159	19	ATP	ATP	NNP
cord-326228-9x1233q6	159	20	synthesis	synthesis	NN
cord-326228-9x1233q6	159	21	,	,	,
cord-326228-9x1233q6	159	22	61	61	CD
cord-326228-9x1233q6	159	23	in	in	IN
cord-326228-9x1233q6	159	24	a	a	DT
cord-326228-9x1233q6	159	25	process	process	NN
cord-326228-9x1233q6	159	26	known	know	VBN
cord-326228-9x1233q6	159	27	as	as	IN
cord-326228-9x1233q6	159	28	the	the	DT
cord-326228-9x1233q6	159	29	Warburg	Warburg	NNP
cord-326228-9x1233q6	159	30	effect	effect	NN
cord-326228-9x1233q6	159	31	.	.	.
cord-326228-9x1233q6	160	1	62	62	CD
cord-326228-9x1233q6	161	1	Signalling	signal	VBG
cord-326228-9x1233q6	161	2	through	through	IN
cord-326228-9x1233q6	161	3	TLRs	TLRs	NNP
cord-326228-9x1233q6	161	4	2	2	CD
cord-326228-9x1233q6	161	5	,	,	,
cord-326228-9x1233q6	161	6	3	3	CD
cord-326228-9x1233q6	161	7	,	,	,
cord-326228-9x1233q6	161	8	4	4	CD
cord-326228-9x1233q6	161	9	and	and	CC
cord-326228-9x1233q6	161	10	9	9	CD
cord-326228-9x1233q6	161	11	induces	induce	VBZ
cord-326228-9x1233q6	161	12	this	this	DT
cord-326228-9x1233q6	161	13	glycolytic	glycolytic	JJ
cord-326228-9x1233q6	161	14	switch	switch	NN
cord-326228-9x1233q6	161	15	during	during	IN
cord-326228-9x1233q6	161	16	macrophage	macrophage	NN
cord-326228-9x1233q6	161	17	activation	activation	NN
cord-326228-9x1233q6	161	18	,	,	,
cord-326228-9x1233q6	161	19	63	63	CD
cord-326228-9x1233q6	161	20	as	as	IN
cord-326228-9x1233q6	161	21	a	a	DT
cord-326228-9x1233q6	161	22	means	means	NN
cord-326228-9x1233q6	161	23	to	to	TO
cord-326228-9x1233q6	161	24	upregulate	upregulate	VB
cord-326228-9x1233q6	161	25	ATP	ATP	NNP
cord-326228-9x1233q6	161	26	production	production	NN
cord-326228-9x1233q6	161	27	for	for	IN
cord-326228-9x1233q6	161	28	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	161	29	and	and	CC
cord-326228-9x1233q6	161	30	antimicrobial	antimicrobial	JJ
cord-326228-9x1233q6	161	31	functions	function	NNS
cord-326228-9x1233q6	161	32	,	,	,
cord-326228-9x1233q6	161	33	albeit	albeit	IN
cord-326228-9x1233q6	161	34	at	at	IN
cord-326228-9x1233q6	161	35	the	the	DT
cord-326228-9x1233q6	161	36	cost	cost	NN
cord-326228-9x1233q6	161	37	of	of	IN
cord-326228-9x1233q6	161	38	energy	energy	NN
cord-326228-9x1233q6	161	39	efficiency	efficiency	NN
cord-326228-9x1233q6	161	40	.	.	.
cord-326228-9x1233q6	162	1	Inflammatory	inflammatory	JJ
cord-326228-9x1233q6	162	2	,	,	,
cord-326228-9x1233q6	162	3	or	or	CC
cord-326228-9x1233q6	162	4	classically	classically	RB
cord-326228-9x1233q6	162	5	activated	activate	VBN
cord-326228-9x1233q6	162	6	,	,	,
cord-326228-9x1233q6	162	7	macrophages	macrophage	NNS
cord-326228-9x1233q6	162	8	promote	promote	VBP
cord-326228-9x1233q6	162	9	glycolysis	glycolysis	NN
cord-326228-9x1233q6	162	10	by	by	IN
cord-326228-9x1233q6	162	11	upregulating	upregulate	VBG
cord-326228-9x1233q6	162	12	hexokinase	hexokinase	NNP
cord-326228-9x1233q6	162	13	and	and	CC
cord-326228-9x1233q6	162	14	glucose-6-phosphate	glucose-6-phosphate	JJ
cord-326228-9x1233q6	162	15	dehydrogenase	dehydrogenase	NN
cord-326228-9x1233q6	162	16	(	(	-LRB-
cord-326228-9x1233q6	162	17	G6PD	G6PD	NNP
cord-326228-9x1233q6	162	18	)	)	-RRB-
cord-326228-9x1233q6	162	19	.	.	.
cord-326228-9x1233q6	163	1	64	64	CD
cord-326228-9x1233q6	164	1	This	this	DT
cord-326228-9x1233q6	164	2	glycolytic	glycolytic	JJ
cord-326228-9x1233q6	164	3	switch	switch	NN
cord-326228-9x1233q6	164	4	mechanism	mechanism	NN
cord-326228-9x1233q6	164	5	may	may	MD
cord-326228-9x1233q6	164	6	contribute	contribute	VB
cord-326228-9x1233q6	164	7	to	to	IN
cord-326228-9x1233q6	164	8	the	the	DT
cord-326228-9x1233q6	164	9	signal	signal	JJ
cord-326228-9x1233q6	164	10	1	1	CD
cord-326228-9x1233q6	164	11	step	step	NN
cord-326228-9x1233q6	164	12	in	in	IN
cord-326228-9x1233q6	164	13	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	164	14	activation	activation	NN
cord-326228-9x1233q6	164	15	,	,	,
cord-326228-9x1233q6	164	16	as	as	IN
cord-326228-9x1233q6	164	17	hexokinase	hexokinase	NNP
cord-326228-9x1233q6	164	18	-	-	HYPH
cord-326228-9x1233q6	164	19	dependent	dependent	JJ
cord-326228-9x1233q6	164	20	glycolysis	glycolysis	NN
cord-326228-9x1233q6	164	21	is	be	VBZ
cord-326228-9x1233q6	164	22	essential	essential	JJ
cord-326228-9x1233q6	164	23	for	for	IN
cord-326228-9x1233q6	164	24	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	164	25	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	164	26	assembly	assembly	NN
cord-326228-9x1233q6	164	27	and	and	CC
cord-326228-9x1233q6	164	28	IL-1b	IL-1b	NNP
cord-326228-9x1233q6	164	29	secretion	secretion	NN
cord-326228-9x1233q6	164	30	.	.	.
cord-326228-9x1233q6	165	1	65	65	CD
cord-326228-9x1233q6	166	1	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	167	1	signalling	signal	VBG
cord-326228-9x1233q6	167	2	in	in	IN
cord-326228-9x1233q6	167	3	microglia	microglia	NN
cord-326228-9x1233q6	167	4	also	also	RB
cord-326228-9x1233q6	167	5	upregulates	upregulate	VBZ
cord-326228-9x1233q6	167	6	glycolysis	glycolysis	NN
cord-326228-9x1233q6	167	7	.	.	.
cord-326228-9x1233q6	168	1	66	66	CD
cord-326228-9x1233q6	169	1	Complexes	complex	NNS
cord-326228-9x1233q6	169	2	I	-PRON-	PRP
cord-326228-9x1233q6	169	3	and	and	CC
cord-326228-9x1233q6	169	4	III	iii	CD
cord-326228-9x1233q6	169	5	of	of	IN
cord-326228-9x1233q6	169	6	the	the	DT
cord-326228-9x1233q6	169	7	electron	electron	NN
cord-326228-9x1233q6	169	8	transport	transport	NN
cord-326228-9x1233q6	169	9	chain	chain	NN
cord-326228-9x1233q6	169	10	generate	generate	VB
cord-326228-9x1233q6	169	11	mitoROS	mitoROS	NNP
cord-326228-9x1233q6	169	12	in	in	IN
cord-326228-9x1233q6	169	13	response	response	NN
cord-326228-9x1233q6	169	14	to	to	IN
cord-326228-9x1233q6	169	15	alteration	alteration	NN
cord-326228-9x1233q6	169	16	in	in	IN
cord-326228-9x1233q6	169	17	the	the	DT
cord-326228-9x1233q6	169	18	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	169	19	membrane	membrane	NN
cord-326228-9x1233q6	169	20	potential	potential	NN
cord-326228-9x1233q6	169	21	.	.	.
cord-326228-9x1233q6	170	1	67,68	67,68	CD
cord-326228-9x1233q6	170	2	R837	r837	SYM
cord-326228-9x1233q6	170	3	9	9	CD
cord-326228-9x1233q6	170	4	and	and	CC
cord-326228-9x1233q6	170	5	likely	likely	JJ
cord-326228-9x1233q6	170	6	other	other	JJ
cord-326228-9x1233q6	170	7	signal	signal	NN
cord-326228-9x1233q6	170	8	2	2	CD
cord-326228-9x1233q6	170	9	stimuli	stimulus	NNS
cord-326228-9x1233q6	171	1	9,69,70	9,69,70	CD
cord-326228-9x1233q6	171	2	disrupt	disrupt	VB
cord-326228-9x1233q6	171	3	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	171	4	OXPHOS	OXPHOS	NNP
cord-326228-9x1233q6	171	5	,	,	,
cord-326228-9x1233q6	171	6	triggering	trigger	VBG
cord-326228-9x1233q6	171	7	mitoROS	mitoros	JJ
cord-326228-9x1233q6	171	8	production	production	NN
cord-326228-9x1233q6	171	9	and	and	CC
cord-326228-9x1233q6	171	10	NLRP3	nlrp3	NN
cord-326228-9x1233q6	171	11	activation	activation	NN
cord-326228-9x1233q6	171	12	.	.	.
cord-326228-9x1233q6	172	1	This	this	DT
cord-326228-9x1233q6	172	2	indicates	indicate	VBZ
cord-326228-9x1233q6	172	3	that	that	IN
cord-326228-9x1233q6	172	4	NLRP3	nlrp3	NN
cord-326228-9x1233q6	172	5	may	may	MD
cord-326228-9x1233q6	172	6	function	function	VB
cord-326228-9x1233q6	172	7	as	as	IN
cord-326228-9x1233q6	172	8	a	a	DT
cord-326228-9x1233q6	172	9	sentinel	sentinel	NN
cord-326228-9x1233q6	172	10	for	for	IN
cord-326228-9x1233q6	172	11	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	172	12	dysfunction	dysfunction	NN
cord-326228-9x1233q6	172	13	in	in	IN
cord-326228-9x1233q6	172	14	specific	specific	JJ
cord-326228-9x1233q6	172	15	circumstances	circumstance	NNS
cord-326228-9x1233q6	172	16	.	.	.
cord-326228-9x1233q6	173	1	Immunometabolic	Immunometabolic	NNP
cord-326228-9x1233q6	173	2	flux	flux	NN
cord-326228-9x1233q6	173	3	,	,	,
cord-326228-9x1233q6	173	4	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	173	5	network	network	NN
cord-326228-9x1233q6	173	6	dynamics	dynamic	NNS
cord-326228-9x1233q6	173	7	and	and	CC
cord-326228-9x1233q6	173	8	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	173	9	depolarisation	depolarisation	NN
cord-326228-9x1233q6	173	10	are	be	VBP
cord-326228-9x1233q6	173	11	all	all	DT
cord-326228-9x1233q6	173	12	tightly	tightly	RB
cord-326228-9x1233q6	173	13	linked	link	VBN
cord-326228-9x1233q6	173	14	.	.	.
cord-326228-9x1233q6	174	1	Loss	loss	NN
cord-326228-9x1233q6	174	2	of	of	IN
cord-326228-9x1233q6	174	3	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	174	4	membrane	membrane	NN
cord-326228-9x1233q6	174	5	potential	potential	NN
cord-326228-9x1233q6	174	6	can	can	MD
cord-326228-9x1233q6	174	7	trigger	trigger	VB
cord-326228-9x1233q6	174	8	metabolic	metabolic	JJ
cord-326228-9x1233q6	174	9	shifts	shift	NNS
cord-326228-9x1233q6	174	10	and	and	CC
cord-326228-9x1233q6	174	11	mitoROS	mitoros	JJ
cord-326228-9x1233q6	174	12	generation	generation	NN
cord-326228-9x1233q6	174	13	,	,	,
cord-326228-9x1233q6	174	14	and	and	CC
cord-326228-9x1233q6	174	15	may	may	MD
cord-326228-9x1233q6	174	16	be	be	VB
cord-326228-9x1233q6	174	17	a	a	DT
cord-326228-9x1233q6	174	18	consequence	consequence	NN
cord-326228-9x1233q6	174	19	of	of	IN
cord-326228-9x1233q6	174	20	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	174	21	permeabilisation	permeabilisation	NN
cord-326228-9x1233q6	174	22	.	.	.
cord-326228-9x1233q6	175	1	Mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	175	2	contain	contain	VBP
cord-326228-9x1233q6	175	3	many	many	JJ
cord-326228-9x1233q6	175	4	molecules	molecule	NNS
cord-326228-9x1233q6	175	5	that	that	WDT
cord-326228-9x1233q6	175	6	are	be	VBP
cord-326228-9x1233q6	175	7	similar	similar	JJ
cord-326228-9x1233q6	175	8	to	to	IN
cord-326228-9x1233q6	175	9	bacterial	bacterial	JJ
cord-326228-9x1233q6	175	10	PAMPs	pamp	NNS
cord-326228-9x1233q6	175	11	and	and	CC
cord-326228-9x1233q6	175	12	are	be	VBP
cord-326228-9x1233q6	175	13	usually	usually	RB
cord-326228-9x1233q6	175	14	shielded	shield	VBN
cord-326228-9x1233q6	175	15	from	from	IN
cord-326228-9x1233q6	175	16	immune	immune	JJ
cord-326228-9x1233q6	175	17	recognition	recognition	NN
cord-326228-9x1233q6	175	18	.	.	.
cord-326228-9x1233q6	176	1	Here	here	RB
cord-326228-9x1233q6	176	2	,	,	,
cord-326228-9x1233q6	176	3	we	-PRON-	PRP
cord-326228-9x1233q6	176	4	review	review	VBP
cord-326228-9x1233q6	176	5	the	the	DT
cord-326228-9x1233q6	176	6	consequences	consequence	NNS
cord-326228-9x1233q6	176	7	of	of	IN
cord-326228-9x1233q6	176	8	liberation	liberation	NN
cord-326228-9x1233q6	176	9	of	of	IN
cord-326228-9x1233q6	176	10	one	one	CD
cord-326228-9x1233q6	176	11	such	such	JJ
cord-326228-9x1233q6	176	12	component	component	NN
cord-326228-9x1233q6	176	13	,	,	,
cord-326228-9x1233q6	176	14	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	176	15	,	,	,
cord-326228-9x1233q6	176	16	for	for	IN
cord-326228-9x1233q6	176	17	recognition	recognition	NN
cord-326228-9x1233q6	176	18	by	by	IN
cord-326228-9x1233q6	176	19	cytosolic	cytosolic	JJ
cord-326228-9x1233q6	176	20	and	and	CC
cord-326228-9x1233q6	176	21	endosomal	endosomal	NNP
cord-326228-9x1233q6	176	22	PRRs	PRRs	NNP
cord-326228-9x1233q6	176	23	,	,	,
cord-326228-9x1233q6	176	24	and	and	CC
cord-326228-9x1233q6	176	25	resultant	resultant	JJ
cord-326228-9x1233q6	176	26	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	176	27	signalling	signalling	NN
cord-326228-9x1233q6	176	28	.	.	.
cord-326228-9x1233q6	177	1	DNA	DNA	NNP
cord-326228-9x1233q6	177	2	is	be	VBZ
cord-326228-9x1233q6	177	3	usually	usually	RB
cord-326228-9x1233q6	177	4	rapidly	rapidly	RB
cord-326228-9x1233q6	177	5	removed	remove	VBN
cord-326228-9x1233q6	177	6	from	from	IN
cord-326228-9x1233q6	177	7	the	the	DT
cord-326228-9x1233q6	177	8	cytosol	cytosol	NN
cord-326228-9x1233q6	177	9	in	in	IN
cord-326228-9x1233q6	177	10	healthy	healthy	JJ
cord-326228-9x1233q6	177	11	eukaryotic	eukaryotic	JJ
cord-326228-9x1233q6	177	12	cells	cell	NNS
cord-326228-9x1233q6	177	13	.	.	.
cord-326228-9x1233q6	178	1	During	during	IN
cord-326228-9x1233q6	178	2	infection	infection	NN
cord-326228-9x1233q6	178	3	or	or	CC
cord-326228-9x1233q6	178	4	cell	cell	NN
cord-326228-9x1233q6	178	5	damage	damage	NN
cord-326228-9x1233q6	178	6	,	,	,
cord-326228-9x1233q6	178	7	the	the	DT
cord-326228-9x1233q6	178	8	amount	amount	NN
cord-326228-9x1233q6	178	9	of	of	IN
cord-326228-9x1233q6	178	10	DNA	dna	NN
cord-326228-9x1233q6	178	11	liberated	liberate	VBN
cord-326228-9x1233q6	178	12	from	from	IN
cord-326228-9x1233q6	178	13	the	the	DT
cord-326228-9x1233q6	178	14	nucleus	nucleus	NN
cord-326228-9x1233q6	178	15	or	or	CC
cord-326228-9x1233q6	178	16	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	178	17	overwhelms	overwhelm	VBZ
cord-326228-9x1233q6	178	18	the	the	DT
cord-326228-9x1233q6	178	19	capacity	capacity	NN
cord-326228-9x1233q6	178	20	for	for	IN
cord-326228-9x1233q6	178	21	cytosolic	cytosolic	JJ
cord-326228-9x1233q6	178	22	DNases	dnase	NNS
cord-326228-9x1233q6	178	23	to	to	TO
cord-326228-9x1233q6	178	24	remove	remove	VB
cord-326228-9x1233q6	178	25	DNA	DNA	NNP
cord-326228-9x1233q6	178	26	,	,	,
cord-326228-9x1233q6	178	27	leading	lead	VBG
cord-326228-9x1233q6	178	28	to	to	IN
cord-326228-9x1233q6	178	29	immune	immune	JJ
cord-326228-9x1233q6	178	30	recognition	recognition	NN
cord-326228-9x1233q6	178	31	by	by	IN
cord-326228-9x1233q6	178	32	PRRs	prr	NNS
cord-326228-9x1233q6	178	33	.	.	.
cord-326228-9x1233q6	179	1	Cytosolic	Cytosolic	NNP
cord-326228-9x1233q6	179	2	DNases	dnase	NNS
cord-326228-9x1233q6	179	3	are	be	VBP
cord-326228-9x1233q6	179	4	also	also	RB
cord-326228-9x1233q6	179	5	transcriptionally	transcriptionally	RB
cord-326228-9x1233q6	179	6	downregulated	downregulate	VBN
cord-326228-9x1233q6	179	7	in	in	IN
cord-326228-9x1233q6	179	8	senescent	senescent	JJ
cord-326228-9x1233q6	179	9	cells	cell	NNS
cord-326228-9x1233q6	179	10	,	,	,
cord-326228-9x1233q6	179	11	71	71	CD
cord-326228-9x1233q6	179	12	suggesting	suggest	VBG
cord-326228-9x1233q6	179	13	that	that	IN
cord-326228-9x1233q6	179	14	PRR	PRR	NNP
cord-326228-9x1233q6	179	15	sensing	sensing	NN
cord-326228-9x1233q6	179	16	of	of	IN
cord-326228-9x1233q6	179	17	accumulated	accumulate	VBN
cord-326228-9x1233q6	179	18	mislocalised	mislocalised	JJ
cord-326228-9x1233q6	179	19	DNA	DNA	NNP
cord-326228-9x1233q6	179	20	may	may	MD
cord-326228-9x1233q6	179	21	contribute	contribute	VB
cord-326228-9x1233q6	179	22	to	to	IN
cord-326228-9x1233q6	179	23	age	age	NN
cord-326228-9x1233q6	179	24	-	-	HYPH
cord-326228-9x1233q6	179	25	related	relate	VBN
cord-326228-9x1233q6	179	26	inflammation	inflammation	NN
cord-326228-9x1233q6	179	27	(	(	-LRB-
cord-326228-9x1233q6	179	28	'	'	``
cord-326228-9x1233q6	179	29	inflammaging	inflammage	VBG
cord-326228-9x1233q6	179	30	'	'	''
cord-326228-9x1233q6	179	31	)	)	-RRB-
cord-326228-9x1233q6	179	32	.	.	.
cord-326228-9x1233q6	180	1	The	the	DT
cord-326228-9x1233q6	180	2	location	location	NN
cord-326228-9x1233q6	180	3	of	of	IN
cord-326228-9x1233q6	180	4	DNA	dna	NN
cord-326228-9x1233q6	180	5	at	at	IN
cord-326228-9x1233q6	180	6	the	the	DT
cord-326228-9x1233q6	180	7	time	time	NN
cord-326228-9x1233q6	180	8	of	of	IN
cord-326228-9x1233q6	180	9	recognition	recognition	NN
cord-326228-9x1233q6	180	10	drives	drive	VBZ
cord-326228-9x1233q6	180	11	compartment	compartment	NN
cord-326228-9x1233q6	180	12	-	-	HYPH
cord-326228-9x1233q6	180	13	specific	specific	JJ
cord-326228-9x1233q6	180	14	responses	response	NNS
cord-326228-9x1233q6	180	15	,	,	,
cord-326228-9x1233q6	180	16	72	72	CD
cord-326228-9x1233q6	180	17	and	and	CC
cord-326228-9x1233q6	180	18	here	here	RB
cord-326228-9x1233q6	180	19	,	,	,
cord-326228-9x1233q6	180	20	we	-PRON-	PRP
cord-326228-9x1233q6	180	21	review	review	VBP
cord-326228-9x1233q6	180	22	mtDNA	mtdna	NN
cord-326228-9x1233q6	180	23	sensing	sensing	NN
cord-326228-9x1233q6	180	24	by	by	IN
cord-326228-9x1233q6	180	25	several	several	JJ
cord-326228-9x1233q6	180	26	key	key	JJ
cord-326228-9x1233q6	180	27	DNA	dna	NN
cord-326228-9x1233q6	180	28	sensors	sensor	NNS
cord-326228-9x1233q6	180	29	in	in	IN
cord-326228-9x1233q6	180	30	innate	innate	JJ
cord-326228-9x1233q6	180	31	immunity	immunity	NN
cord-326228-9x1233q6	180	32	(	(	-LRB-
cord-326228-9x1233q6	180	33	Figures	figure	NNS
cord-326228-9x1233q6	180	34	2	2	CD
cord-326228-9x1233q6	180	35	and	and	CC
cord-326228-9x1233q6	180	36	3	3	CD
cord-326228-9x1233q6	180	37	)	)	-RRB-
cord-326228-9x1233q6	180	38	.	.	.
cord-326228-9x1233q6	181	1	Nod	nod	JJ
cord-326228-9x1233q6	181	2	-	-	HYPH
cord-326228-9x1233q6	181	3	like	like	JJ
cord-326228-9x1233q6	181	4	receptor	receptor	NN
cord-326228-9x1233q6	181	5	protein	protein	NN
cord-326228-9x1233q6	181	6	3	3	CD
cord-326228-9x1233q6	181	7	is	be	VBZ
cord-326228-9x1233q6	181	8	a	a	DT
cord-326228-9x1233q6	181	9	well	well	RB
cord-326228-9x1233q6	181	10	-	-	HYPH
cord-326228-9x1233q6	181	11	characterised	characterise	VBN
cord-326228-9x1233q6	181	12	cytoplasmic	cytoplasmic	JJ
cord-326228-9x1233q6	181	13	sensor	sensor	NN
cord-326228-9x1233q6	181	14	for	for	IN
cord-326228-9x1233q6	181	15	cell	cell	NN
cord-326228-9x1233q6	181	16	stress	stress	NN
cord-326228-9x1233q6	181	17	.	.	.
cord-326228-9x1233q6	182	1	One	one	CD
cord-326228-9x1233q6	182	2	reported	report	VBN
cord-326228-9x1233q6	182	3	mechanism	mechanism	NN
cord-326228-9x1233q6	182	4	of	of	IN
cord-326228-9x1233q6	182	5	stress	stress	NN
cord-326228-9x1233q6	182	6	sensing	sensing	NN
cord-326228-9x1233q6	182	7	involves	involve	VBZ
cord-326228-9x1233q6	182	8	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	182	9	recognition	recognition	NN
cord-326228-9x1233q6	182	10	of	of	IN
cord-326228-9x1233q6	182	11	mislocalised	mislocalised	NNP
cord-326228-9x1233q6	182	12	mtDNA	mtdna	NN
cord-326228-9x1233q6	182	13	during	during	IN
cord-326228-9x1233q6	182	14	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	182	15	dysfunction	dysfunction	NN
cord-326228-9x1233q6	182	16	.	.	.
cord-326228-9x1233q6	183	1	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	183	2	activation	activation	NN
cord-326228-9x1233q6	183	3	in	in	IN
cord-326228-9x1233q6	183	4	mouse	mouse	NN
cord-326228-9x1233q6	183	5	macrophages	macrophage	NNS
cord-326228-9x1233q6	183	6	can	can	MD
cord-326228-9x1233q6	183	7	be	be	VB
cord-326228-9x1233q6	183	8	associated	associate	VBN
cord-326228-9x1233q6	183	9	with	with	IN
cord-326228-9x1233q6	183	10	loss	loss	NN
cord-326228-9x1233q6	183	11	of	of	IN
cord-326228-9x1233q6	183	12	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	183	13	membrane	membrane	NN
cord-326228-9x1233q6	183	14	potential	potential	JJ
cord-326228-9x1233q6	183	15	or	or	CC
cord-326228-9x1233q6	183	16	defective	defective	JJ
cord-326228-9x1233q6	183	17	mitophagy	mitophagy	NN
cord-326228-9x1233q6	183	18	,	,	,
cord-326228-9x1233q6	183	19	leading	lead	VBG
cord-326228-9x1233q6	183	20	to	to	IN
cord-326228-9x1233q6	183	21	mitoROS	mitoros	JJ
cord-326228-9x1233q6	183	22	production	production	NN
cord-326228-9x1233q6	183	23	and	and	CC
cord-326228-9x1233q6	183	24	mtDNA	mtdna	NN
cord-326228-9x1233q6	183	25	release	release	NN
cord-326228-9x1233q6	183	26	from	from	IN
cord-326228-9x1233q6	183	27	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	183	28	to	to	IN
cord-326228-9x1233q6	183	29	the	the	DT
cord-326228-9x1233q6	183	30	cytosol	cytosol	NN
cord-326228-9x1233q6	183	31	.	.	.
cord-326228-9x1233q6	184	1	69	69	CD
cord-326228-9x1233q6	184	2	,	,	,
cord-326228-9x1233q6	184	3	[	[	-LRB-
cord-326228-9x1233q6	184	4	73	73	CD
cord-326228-9x1233q6	184	5	]	]	-RRB-
cord-326228-9x1233q6	184	6	[	[	-LRB-
cord-326228-9x1233q6	184	7	74	74	CD
cord-326228-9x1233q6	184	8	]	]	-RRB-
cord-326228-9x1233q6	184	9	[	[	-LRB-
cord-326228-9x1233q6	184	10	75	75	CD
cord-326228-9x1233q6	184	11	]	]	-RRB-
cord-326228-9x1233q6	184	12	Oxidised	oxidise	VBN
cord-326228-9x1233q6	184	13	mtDNA	mtdna	NN
cord-326228-9x1233q6	184	14	was	be	VBD
cord-326228-9x1233q6	184	15	reported	report	VBN
cord-326228-9x1233q6	184	16	to	to	TO
cord-326228-9x1233q6	184	17	promote	promote	VB
cord-326228-9x1233q6	184	18	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	184	19	activation	activation	NN
cord-326228-9x1233q6	184	20	.	.	.
cord-326228-9x1233q6	185	1	14	14	CD
cord-326228-9x1233q6	186	1	In	in	IN
cord-326228-9x1233q6	186	2	this	this	DT
cord-326228-9x1233q6	186	3	study	study	NN
cord-326228-9x1233q6	186	4	,	,	,
cord-326228-9x1233q6	186	5	the	the	DT
cord-326228-9x1233q6	186	6	authors	author	NNS
cord-326228-9x1233q6	186	7	observed	observe	VBD
cord-326228-9x1233q6	186	8	direct	direct	JJ
cord-326228-9x1233q6	186	9	interaction	interaction	NN
cord-326228-9x1233q6	186	10	between	between	IN
cord-326228-9x1233q6	186	11	transfected	transfecte	VBN
cord-326228-9x1233q6	186	12	bromodeoxyuridine	bromodeoxyuridine	NN
cord-326228-9x1233q6	186	13	(	(	-LRB-
cord-326228-9x1233q6	186	14	BrdU)-labelled	brdu)-labelle	VBN
cord-326228-9x1233q6	186	15	mtDNA	mtdna	NN
cord-326228-9x1233q6	186	16	and	and	CC
cord-326228-9x1233q6	186	17	ectopically	ectopically	RB
cord-326228-9x1233q6	186	18	expressed	express	VBD
cord-326228-9x1233q6	186	19	NLRP3	nlrp3	NN
cord-326228-9x1233q6	186	20	in	in	IN
cord-326228-9x1233q6	186	21	HEK293	HEK293	NNP
cord-326228-9x1233q6	186	22	cells	cell	NNS
cord-326228-9x1233q6	186	23	,	,	,
cord-326228-9x1233q6	186	24	suggestive	suggestive	JJ
cord-326228-9x1233q6	186	25	of	of	IN
cord-326228-9x1233q6	186	26	a	a	DT
cord-326228-9x1233q6	186	27	ligand	ligand	NN
cord-326228-9x1233q6	186	28	-	-	HYPH
cord-326228-9x1233q6	186	29	receptor	receptor	NN
cord-326228-9x1233q6	186	30	relationship	relationship	NN
cord-326228-9x1233q6	186	31	.	.	.
cord-326228-9x1233q6	187	1	In	in	IN
cord-326228-9x1233q6	187	2	wild	wild	JJ
cord-326228-9x1233q6	187	3	-	-	HYPH
cord-326228-9x1233q6	187	4	type	type	NN
cord-326228-9x1233q6	187	5	BMDMs	bmdms	NN
cord-326228-9x1233q6	187	6	,	,	,
cord-326228-9x1233q6	187	7	endogenous	endogenous	JJ
cord-326228-9x1233q6	187	8	mtDNA	mtdna	NN
cord-326228-9x1233q6	187	9	labelled	label	VBN
cord-326228-9x1233q6	187	10	with	with	IN
cord-326228-9x1233q6	187	11	BrdU	BrdU	NNP
cord-326228-9x1233q6	187	12	co	co	JJ
cord-326228-9x1233q6	187	13	-	-	JJ
cord-326228-9x1233q6	187	14	immunoprecipitated	immunoprecipitated	JJ
cord-326228-9x1233q6	187	15	with	with	IN
cord-326228-9x1233q6	187	16	NLRP3	nlrp3	NN
cord-326228-9x1233q6	187	17	after	after	IN
cord-326228-9x1233q6	187	18	LPS	lp	NNS
cord-326228-9x1233q6	187	19	priming	priming	NN
cord-326228-9x1233q6	187	20	and	and	CC
cord-326228-9x1233q6	187	21	a	a	DT
cord-326228-9x1233q6	187	22	signal	signal	NN
cord-326228-9x1233q6	187	23	2	2	CD
cord-326228-9x1233q6	188	1	(	(	-LRB-
cord-326228-9x1233q6	188	2	nigericin	nigericin	NNP
cord-326228-9x1233q6	188	3	or	or	CC
cord-326228-9x1233q6	188	4	ATP	ATP	NNP
cord-326228-9x1233q6	188	5	)	)	-RRB-
cord-326228-9x1233q6	188	6	;	;	:
cord-326228-9x1233q6	188	7	however	however	RB
cord-326228-9x1233q6	188	8	,	,	,
cord-326228-9x1233q6	188	9	this	this	DT
cord-326228-9x1233q6	188	10	study	study	NN
cord-326228-9x1233q6	188	11	did	do	VBD
cord-326228-9x1233q6	188	12	not	not	RB
cord-326228-9x1233q6	188	13	confirm	confirm	VB
cord-326228-9x1233q6	188	14	that	that	IN
cord-326228-9x1233q6	188	15	this	this	DT
cord-326228-9x1233q6	188	16	interaction	interaction	NN
cord-326228-9x1233q6	188	17	was	be	VBD
cord-326228-9x1233q6	188	18	upstream	upstream	RB
cord-326228-9x1233q6	188	19	,	,	,
cord-326228-9x1233q6	188	20	rather	rather	RB
cord-326228-9x1233q6	188	21	than	than	IN
cord-326228-9x1233q6	188	22	downstream	downstream	JJ
cord-326228-9x1233q6	188	23	,	,	,
cord-326228-9x1233q6	188	24	of	of	IN
cord-326228-9x1233q6	188	25	NLRP3	nlrp3	NN
cord-326228-9x1233q6	188	26	signalling	signalling	NN
cord-326228-9x1233q6	188	27	.	.	.
cord-326228-9x1233q6	189	1	Since	since	IN
cord-326228-9x1233q6	189	2	this	this	DT
cord-326228-9x1233q6	189	3	initial	initial	JJ
cord-326228-9x1233q6	189	4	report	report	NN
cord-326228-9x1233q6	189	5	that	that	IN
cord-326228-9x1233q6	189	6	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	189	7	may	may	MD
cord-326228-9x1233q6	189	8	activate	activate	VB
cord-326228-9x1233q6	189	9	NLRP3	nlrp3	XX
cord-326228-9x1233q6	189	10	,	,	,
cord-326228-9x1233q6	189	11	subsequent	subsequent	JJ
cord-326228-9x1233q6	189	12	studies	study	NNS
cord-326228-9x1233q6	189	13	have	have	VBP
cord-326228-9x1233q6	189	14	disagreed	disagree	VBN
cord-326228-9x1233q6	189	15	over	over	IN
cord-326228-9x1233q6	189	16	the	the	DT
cord-326228-9x1233q6	189	17	sequence	sequence	NN
cord-326228-9x1233q6	189	18	of	of	IN
cord-326228-9x1233q6	189	19	events	event	NNS
cord-326228-9x1233q6	189	20	leading	lead	VBG
cord-326228-9x1233q6	189	21	to	to	IN
cord-326228-9x1233q6	189	22	mtDNA	mtdna	JJ
cord-326228-9x1233q6	189	23	liberation	liberation	NN
cord-326228-9x1233q6	189	24	and	and	CC
cord-326228-9x1233q6	189	25	sensing	sensing	NN
cord-326228-9x1233q6	189	26	by	by	IN
cord-326228-9x1233q6	189	27	NLRP3	nlrp3	NN
cord-326228-9x1233q6	189	28	.	.	.
cord-326228-9x1233q6	190	1	Several	several	JJ
cord-326228-9x1233q6	190	2	groups	group	NNS
cord-326228-9x1233q6	190	3	describe	describe	VBP
cord-326228-9x1233q6	190	4	mtDNA	mtdna	NN
cord-326228-9x1233q6	190	5	release	release	NN
cord-326228-9x1233q6	190	6	as	as	IN
cord-326228-9x1233q6	190	7	a	a	DT
cord-326228-9x1233q6	190	8	signal	signal	JJ
cord-326228-9x1233q6	190	9	2-dependent	2-dependent	CD
cord-326228-9x1233q6	190	10	,	,	,
cord-326228-9x1233q6	190	11	NLRP3independent	NLRP3independent	NNP
cord-326228-9x1233q6	190	12	process	process	NN
cord-326228-9x1233q6	190	13	that	that	WDT
cord-326228-9x1233q6	190	14	is	be	VBZ
cord-326228-9x1233q6	190	15	required	require	VBN
cord-326228-9x1233q6	190	16	for	for	IN
cord-326228-9x1233q6	190	17	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	190	18	activation	activation	NN
cord-326228-9x1233q6	190	19	.	.	.
cord-326228-9x1233q6	191	1	[	[	-LRB-
cord-326228-9x1233q6	191	2	74	74	CD
cord-326228-9x1233q6	191	3	]	]	-RRB-
cord-326228-9x1233q6	191	4	[	[	-LRB-
cord-326228-9x1233q6	191	5	75	75	CD
cord-326228-9x1233q6	191	6	]	]	-RRB-
cord-326228-9x1233q6	191	7	[	[	-LRB-
cord-326228-9x1233q6	191	8	76	76	CD
cord-326228-9x1233q6	191	9	]	]	-RRB-
cord-326228-9x1233q6	192	1	In	in	IN
cord-326228-9x1233q6	192	2	one	one	CD
cord-326228-9x1233q6	192	3	report	report	NN
cord-326228-9x1233q6	192	4	,	,	,
cord-326228-9x1233q6	192	5	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	192	6	immunoprecipitated	immunoprecipitate	VBD
cord-326228-9x1233q6	192	7	with	with	IN
cord-326228-9x1233q6	192	8	the	the	DT
cord-326228-9x1233q6	192	9	NLRP3	nlrp3	NN
cord-326228-9x1233q6	192	10	complex	complex	NN
cord-326228-9x1233q6	192	11	after	after	IN
cord-326228-9x1233q6	192	12	mouse	mouse	NN
cord-326228-9x1233q6	192	13	BMDMs	bmdm	NNS
cord-326228-9x1233q6	192	14	were	be	VBD
cord-326228-9x1233q6	192	15	treated	treat	VBN
cord-326228-9x1233q6	192	16	with	with	IN
cord-326228-9x1233q6	192	17	palmitic	palmitic	JJ
cord-326228-9x1233q6	192	18	acid	acid	NN
cord-326228-9x1233q6	192	19	.	.	.
cord-326228-9x1233q6	193	1	75	75	CD
cord-326228-9x1233q6	194	1	In	in	IN
cord-326228-9x1233q6	194	2	another	another	DT
cord-326228-9x1233q6	194	3	,	,	,
cord-326228-9x1233q6	194	4	TLR4	TLR4	NNP
cord-326228-9x1233q6	194	5	ligation	ligation	NN
cord-326228-9x1233q6	194	6	by	by	IN
cord-326228-9x1233q6	194	7	LPS	lp	NNS
cord-326228-9x1233q6	194	8	(	(	-LRB-
cord-326228-9x1233q6	194	9	signal	signal	NNP
cord-326228-9x1233q6	194	10	1	1	CD
cord-326228-9x1233q6	194	11	)	)	-RRB-
cord-326228-9x1233q6	194	12	upregulated	upregulate	VBN
cord-326228-9x1233q6	194	13	mtDNA	mtdna	JJ
cord-326228-9x1233q6	194	14	synthesis	synthesis	NN
cord-326228-9x1233q6	194	15	,	,	,
cord-326228-9x1233q6	194	16	while	while	IN
cord-326228-9x1233q6	194	17	NLRP3	nlrp3	NN
cord-326228-9x1233q6	194	18	activators	activator	NNS
cord-326228-9x1233q6	194	19	(	(	-LRB-
cord-326228-9x1233q6	194	20	signal	signal	NNP
cord-326228-9x1233q6	194	21	2	2	CD
cord-326228-9x1233q6	194	22	;	;	:
cord-326228-9x1233q6	194	23	ATP	ATP	NNP
cord-326228-9x1233q6	194	24	,	,	,
cord-326228-9x1233q6	194	25	nigericin	nigericin	NNPS
cord-326228-9x1233q6	194	26	)	)	-RRB-
cord-326228-9x1233q6	194	27	promoted	promote	VBD
cord-326228-9x1233q6	194	28	colocalisation	colocalisation	NN
cord-326228-9x1233q6	194	29	of	of	IN
cord-326228-9x1233q6	194	30	oxidised	oxidise	VBN
cord-326228-9x1233q6	194	31	mtDNA	mtdna	NN
cord-326228-9x1233q6	194	32	with	with	IN
cord-326228-9x1233q6	194	33	the	the	DT
cord-326228-9x1233q6	194	34	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	194	35	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	194	36	.	.	.
cord-326228-9x1233q6	195	1	76	76	CD
cord-326228-9x1233q6	196	1	In	in	IN
cord-326228-9x1233q6	196	2	all	all	DT
cord-326228-9x1233q6	196	3	,	,	,
cord-326228-9x1233q6	196	4	these	these	DT
cord-326228-9x1233q6	196	5	reports	report	NNS
cord-326228-9x1233q6	196	6	suggest	suggest	VBP
cord-326228-9x1233q6	196	7	a	a	DT
cord-326228-9x1233q6	196	8	model	model	NN
cord-326228-9x1233q6	196	9	in	in	IN
cord-326228-9x1233q6	196	10	which	which	WDT
cord-326228-9x1233q6	196	11	mtDNA	mtdna	JJ
cord-326228-9x1233q6	196	12	liberation	liberation	NN
cord-326228-9x1233q6	196	13	from	from	IN
cord-326228-9x1233q6	196	14	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	196	15	occurs	occur	VBZ
cord-326228-9x1233q6	196	16	prior	prior	RB
cord-326228-9x1233q6	196	17	to	to	IN
cord-326228-9x1233q6	196	18	,	,	,
cord-326228-9x1233q6	196	19	and	and	CC
cord-326228-9x1233q6	196	20	is	be	VBZ
cord-326228-9x1233q6	196	21	required	require	VBN
cord-326228-9x1233q6	196	22	for	for	IN
cord-326228-9x1233q6	196	23	,	,	,
cord-326228-9x1233q6	196	24	activation	activation	NN
cord-326228-9x1233q6	196	25	of	of	IN
cord-326228-9x1233q6	196	26	the	the	DT
cord-326228-9x1233q6	196	27	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	196	28	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	196	29	(	(	-LRB-
cord-326228-9x1233q6	196	30	Figure	figure	NN
cord-326228-9x1233q6	196	31	2a	2a	CD
cord-326228-9x1233q6	196	32	)	)	-RRB-
cord-326228-9x1233q6	196	33	.	.	.
cord-326228-9x1233q6	197	1	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	197	2	can	can	MD
cord-326228-9x1233q6	197	3	also	also	RB
cord-326228-9x1233q6	197	4	sense	sense	VB
cord-326228-9x1233q6	197	5	cytosolic	cytosolic	JJ
cord-326228-9x1233q6	197	6	DNA	dna	NN
cord-326228-9x1233q6	197	7	indirectly	indirectly	RB
cord-326228-9x1233q6	197	8	,	,	,
cord-326228-9x1233q6	197	9	via	via	IN
cord-326228-9x1233q6	197	10	cell	cell	NN
cord-326228-9x1233q6	197	11	signalling	signal	VBG
cord-326228-9x1233q6	197	12	through	through	IN
cord-326228-9x1233q6	197	13	the	the	DT
cord-326228-9x1233q6	197	14	cyclic	cyclic	JJ
cord-326228-9x1233q6	197	15	GMP	GMP	NNP
cord-326228-9x1233q6	197	16	-	-	HYPH
cord-326228-9x1233q6	197	17	AMP	AMP	NNP
cord-326228-9x1233q6	197	18	synthase	synthase	NN
cord-326228-9x1233q6	197	19	(	(	-LRB-
cord-326228-9x1233q6	197	20	cGAS)/stimulator	cgas)/stimulator	NN
cord-326228-9x1233q6	197	21	of	of	IN
cord-326228-9x1233q6	197	22	IFN	IFN	NNP
cord-326228-9x1233q6	197	23	genes	gene	NNS
cord-326228-9x1233q6	197	24	(	(	-LRB-
cord-326228-9x1233q6	197	25	STING	sting	NN
cord-326228-9x1233q6	197	26	)	)	-RRB-
cord-326228-9x1233q6	197	27	axis	axis	NN
cord-326228-9x1233q6	197	28	.	.	.
cord-326228-9x1233q6	198	1	77	77	CD
cord-326228-9x1233q6	198	2	cellular	cellular	JJ
cord-326228-9x1233q6	198	3	K	k	NN
cord-326228-9x1233q6	198	4	+	+	CC
cord-326228-9x1233q6	198	5	efflux	efflux	NN
cord-326228-9x1233q6	198	6	to	to	TO
cord-326228-9x1233q6	198	7	activate	activate	VB
cord-326228-9x1233q6	198	8	NLRP3	nlrp3	XX
cord-326228-9x1233q6	198	9	;	;	:
cord-326228-9x1233q6	198	10	however	however	RB
cord-326228-9x1233q6	198	11	,	,	,
cord-326228-9x1233q6	198	12	it	-PRON-	PRP
cord-326228-9x1233q6	198	13	is	be	VBZ
cord-326228-9x1233q6	198	14	unclear	unclear	JJ
cord-326228-9x1233q6	198	15	whether	whether	IN
cord-326228-9x1233q6	198	16	ionic	ionic	JJ
cord-326228-9x1233q6	198	17	flux	flux	NN
cord-326228-9x1233q6	198	18	drives	drive	VBZ
cord-326228-9x1233q6	198	19	NLRP3	nlrp3	XX
cord-326228-9x1233q6	198	20	activation	activation	NN
cord-326228-9x1233q6	198	21	in	in	IN
cord-326228-9x1233q6	198	22	parallel	parallel	NN
cord-326228-9x1233q6	198	23	to	to	IN
cord-326228-9x1233q6	198	24	,	,	,
cord-326228-9x1233q6	198	25	or	or	CC
cord-326228-9x1233q6	198	26	up	up	RB
cord-326228-9x1233q6	198	27	-	-	HYPH
cord-326228-9x1233q6	198	28	or	or	CC
cord-326228-9x1233q6	198	29	downstream	downstream	RB
cord-326228-9x1233q6	198	30	of	of	IN
cord-326228-9x1233q6	198	31	,	,	,
cord-326228-9x1233q6	198	32	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	198	33	disruption	disruption	NN
cord-326228-9x1233q6	198	34	and	and	CC
cord-326228-9x1233q6	198	35	mtDNA	mtdna	NN
cord-326228-9x1233q6	198	36	release	release	NN
cord-326228-9x1233q6	198	37	.	.	.
cord-326228-9x1233q6	199	1	Additionally	additionally	RB
cord-326228-9x1233q6	199	2	,	,	,
cord-326228-9x1233q6	199	3	nigericin	nigericin	NNS
cord-326228-9x1233q6	199	4	can	can	MD
cord-326228-9x1233q6	199	5	integrate	integrate	VB
cord-326228-9x1233q6	199	6	directly	directly	RB
cord-326228-9x1233q6	199	7	into	into	IN
cord-326228-9x1233q6	199	8	the	the	DT
cord-326228-9x1233q6	199	9	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	199	10	outer	outer	JJ
cord-326228-9x1233q6	199	11	membrane	membrane	NN
cord-326228-9x1233q6	199	12	to	to	TO
cord-326228-9x1233q6	199	13	induce	induce	VB
cord-326228-9x1233q6	199	14	hyperpolarisation	hyperpolarisation	NN
cord-326228-9x1233q6	199	15	,	,	,
cord-326228-9x1233q6	199	16	78	78	CD
cord-326228-9x1233q6	199	17	and	and	CC
cord-326228-9x1233q6	199	18	so	so	RB
cord-326228-9x1233q6	199	19	some	some	DT
cord-326228-9x1233q6	199	20	signal	signal	JJ
cord-326228-9x1233q6	199	21	2	2	CD
cord-326228-9x1233q6	199	22	stimuli	stimulus	NNS
cord-326228-9x1233q6	199	23	may	may	MD
cord-326228-9x1233q6	199	24	directly	directly	RB
cord-326228-9x1233q6	199	25	perturb	perturb	VB
cord-326228-9x1233q6	199	26	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	199	27	in	in	IN
cord-326228-9x1233q6	199	28	parallel	parallel	NN
cord-326228-9x1233q6	199	29	to	to	IN
cord-326228-9x1233q6	199	30	inducing	induce	VBG
cord-326228-9x1233q6	199	31	ionic	ionic	JJ
cord-326228-9x1233q6	199	32	changes	change	NNS
cord-326228-9x1233q6	199	33	in	in	IN
cord-326228-9x1233q6	199	34	the	the	DT
cord-326228-9x1233q6	199	35	cytosol	cytosol	NN
cord-326228-9x1233q6	199	36	.	.	.
cord-326228-9x1233q6	200	1	Other	other	JJ
cord-326228-9x1233q6	200	2	studies	study	NNS
cord-326228-9x1233q6	200	3	suggest	suggest	VBP
cord-326228-9x1233q6	200	4	an	an	DT
cord-326228-9x1233q6	200	5	alternative	alternative	JJ
cord-326228-9x1233q6	200	6	model	model	NN
cord-326228-9x1233q6	200	7	,	,	,
cord-326228-9x1233q6	200	8	in	in	IN
cord-326228-9x1233q6	200	9	which	which	WDT
cord-326228-9x1233q6	200	10	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	200	11	permeabilisation	permeabilisation	NN
cord-326228-9x1233q6	200	12	is	be	VBZ
cord-326228-9x1233q6	200	13	not	not	RB
cord-326228-9x1233q6	200	14	upstream	upstream	RB
cord-326228-9x1233q6	200	15	of	of	IN
cord-326228-9x1233q6	200	16	NLRP3	nlrp3	NN
cord-326228-9x1233q6	200	17	,	,	,
cord-326228-9x1233q6	200	18	but	but	CC
cord-326228-9x1233q6	200	19	is	be	VBZ
cord-326228-9x1233q6	200	20	instead	instead	RB
cord-326228-9x1233q6	200	21	a	a	DT
cord-326228-9x1233q6	200	22	partial	partial	JJ
cord-326228-9x1233q6	200	23	or	or	CC
cord-326228-9x1233q6	200	24	full	full	JJ
cord-326228-9x1233q6	200	25	consequence	consequence	NN
cord-326228-9x1233q6	200	26	of	of	IN
cord-326228-9x1233q6	200	27	NLRP3	nlrp3	NN
cord-326228-9x1233q6	200	28	signalling	signalling	NN
cord-326228-9x1233q6	200	29	(	(	-LRB-
cord-326228-9x1233q6	200	30	Figure	figure	NN
cord-326228-9x1233q6	200	31	2b	2b	CD
cord-326228-9x1233q6	200	32	)	)	-RRB-
cord-326228-9x1233q6	200	33	.	.	.
cord-326228-9x1233q6	201	1	Disabling	disable	VBG
cord-326228-9x1233q6	201	2	autophagy	autophagy	NN
cord-326228-9x1233q6	201	3	(	(	-LRB-
cord-326228-9x1233q6	201	4	and	and	CC
cord-326228-9x1233q6	201	5	by	by	IN
cord-326228-9x1233q6	201	6	extension	extension	NN
cord-326228-9x1233q6	201	7	mitophagy	mitophagy	NNP
cord-326228-9x1233q6	201	8	)	)	-RRB-
cord-326228-9x1233q6	201	9	in	in	IN
cord-326228-9x1233q6	201	10	mouse	mouse	NN
cord-326228-9x1233q6	201	11	BMDMs	bmdm	NNS
cord-326228-9x1233q6	201	12	resulted	result	VBD
cord-326228-9x1233q6	201	13	in	in	IN
cord-326228-9x1233q6	201	14	mitoROS	mitoROS	NNP
cord-326228-9x1233q6	201	15	-	-	:
cord-326228-9x1233q6	201	16	and	and	CC
cord-326228-9x1233q6	201	17	NLRP3-dependent	NLRP3-dependent	NNP
cord-326228-9x1233q6	201	18	liberation	liberation	NN
cord-326228-9x1233q6	201	19	of	of	IN
cord-326228-9x1233q6	201	20	mtDNA	mtdna	NN
cord-326228-9x1233q6	201	21	from	from	IN
cord-326228-9x1233q6	201	22	the	the	DT
cord-326228-9x1233q6	201	23	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	201	24	matrix	matrix	NN
cord-326228-9x1233q6	201	25	.	.	.
cord-326228-9x1233q6	202	1	73	73	CD
cord-326228-9x1233q6	203	1	Here	here	RB
cord-326228-9x1233q6	203	2	,	,	,
cord-326228-9x1233q6	203	3	retention	retention	NN
cord-326228-9x1233q6	203	4	of	of	IN
cord-326228-9x1233q6	203	5	dysfunctional	dysfunctional	JJ
cord-326228-9x1233q6	203	6	or	or	CC
cord-326228-9x1233q6	203	7	damaged	damaged	JJ
cord-326228-9x1233q6	203	8	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	203	9	was	be	VBD
cord-326228-9x1233q6	203	10	alone	alone	RB
cord-326228-9x1233q6	203	11	insufficient	insufficient	JJ
cord-326228-9x1233q6	203	12	for	for	IN
cord-326228-9x1233q6	203	13	mtDNA	mtdna	JJ
cord-326228-9x1233q6	203	14	translocation	translocation	NN
cord-326228-9x1233q6	203	15	to	to	IN
cord-326228-9x1233q6	203	16	the	the	DT
cord-326228-9x1233q6	203	17	cytosol	cytosol	NN
cord-326228-9x1233q6	203	18	;	;	:
cord-326228-9x1233q6	203	19	the	the	DT
cord-326228-9x1233q6	203	20	latter	latter	JJ
cord-326228-9x1233q6	203	21	required	require	VBD
cord-326228-9x1233q6	203	22	NLRP3	nlrp3	NN
cord-326228-9x1233q6	203	23	signalling	signalling	NN
cord-326228-9x1233q6	203	24	.	.	.
cord-326228-9x1233q6	204	1	Another	another	DT
cord-326228-9x1233q6	204	2	study	study	NN
cord-326228-9x1233q6	204	3	reported	report	VBD
cord-326228-9x1233q6	204	4	the	the	DT
cord-326228-9x1233q6	204	5	loss	loss	NN
cord-326228-9x1233q6	204	6	of	of	IN
cord-326228-9x1233q6	204	7	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	204	8	membrane	membrane	NN
cord-326228-9x1233q6	204	9	potential	potential	NN
cord-326228-9x1233q6	204	10	as	as	IN
cord-326228-9x1233q6	204	11	NLRP3dependent	NLRP3dependent	NNP
cord-326228-9x1233q6	204	12	,	,	,
cord-326228-9x1233q6	204	13	yet	yet	CC
cord-326228-9x1233q6	204	14	caspase-1-independent	caspase-1-independent	NNP
cord-326228-9x1233q6	204	15	.	.	.
cord-326228-9x1233q6	205	1	69	69	CD
cord-326228-9x1233q6	206	1	In	in	IN
cord-326228-9x1233q6	206	2	keeping	keep	VBG
cord-326228-9x1233q6	206	3	with	with	IN
cord-326228-9x1233q6	206	4	the	the	DT
cord-326228-9x1233q6	206	5	assertion	assertion	NN
cord-326228-9x1233q6	206	6	that	that	IN
cord-326228-9x1233q6	206	7	loss	loss	NN
cord-326228-9x1233q6	206	8	of	of	IN
cord-326228-9x1233q6	206	9	membrane	membrane	NN
cord-326228-9x1233q6	206	10	potential	potential	NN
cord-326228-9x1233q6	206	11	is	be	VBZ
cord-326228-9x1233q6	206	12	a	a	DT
cord-326228-9x1233q6	206	13	consequence	consequence	NN
cord-326228-9x1233q6	206	14	rather	rather	RB
cord-326228-9x1233q6	206	15	than	than	IN
cord-326228-9x1233q6	206	16	cause	cause	NN
cord-326228-9x1233q6	206	17	of	of	IN
cord-326228-9x1233q6	206	18	NLRP3	nlrp3	NN
cord-326228-9x1233q6	206	19	activation	activation	NN
cord-326228-9x1233q6	206	20	,	,	,
cord-326228-9x1233q6	206	21	another	another	DT
cord-326228-9x1233q6	206	22	study	study	NN
cord-326228-9x1233q6	206	23	reported	report	VBD
cord-326228-9x1233q6	206	24	that	that	IN
cord-326228-9x1233q6	206	25	NLRP3	nlrp3	XX
cord-326228-9x1233q6	206	26	deficiency	deficiency	NN
cord-326228-9x1233q6	206	27	in	in	IN
cord-326228-9x1233q6	206	28	renal	renal	JJ
cord-326228-9x1233q6	206	29	tubular	tubular	JJ
cord-326228-9x1233q6	206	30	cells	cell	NNS
cord-326228-9x1233q6	206	31	protected	protect	VBD
cord-326228-9x1233q6	206	32	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	206	33	against	against	IN
cord-326228-9x1233q6	206	34	depolarisation	depolarisation	NN
cord-326228-9x1233q6	206	35	during	during	IN
cord-326228-9x1233q6	206	36	hypoxia	hypoxia	NN
cord-326228-9x1233q6	206	37	.	.	.
cord-326228-9x1233q6	207	1	79	79	CD
cord-326228-9x1233q6	208	1	The	the	DT
cord-326228-9x1233q6	208	2	above	above	JJ
cord-326228-9x1233q6	208	3	models	model	NNS
cord-326228-9x1233q6	208	4	may	may	MD
cord-326228-9x1233q6	208	5	not	not	RB
cord-326228-9x1233q6	208	6	be	be	VB
cord-326228-9x1233q6	208	7	mutually	mutually	RB
cord-326228-9x1233q6	208	8	exclusive	exclusive	JJ
cord-326228-9x1233q6	208	9	;	;	:
cord-326228-9x1233q6	208	10	it	-PRON-	PRP
cord-326228-9x1233q6	208	11	is	be	VBZ
cord-326228-9x1233q6	208	12	possible	possible	JJ
cord-326228-9x1233q6	208	13	that	that	IN
cord-326228-9x1233q6	208	14	an	an	DT
cord-326228-9x1233q6	208	15	early	early	JJ
cord-326228-9x1233q6	208	16	loss	loss	NN
cord-326228-9x1233q6	208	17	of	of	IN
cord-326228-9x1233q6	208	18	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	208	19	membrane	membrane	NN
cord-326228-9x1233q6	208	20	integrity	integrity	NN
cord-326228-9x1233q6	208	21	results	result	NNS
cord-326228-9x1233q6	208	22	in	in	IN
cord-326228-9x1233q6	208	23	just	just	RB
cord-326228-9x1233q6	208	24	enough	enough	JJ
cord-326228-9x1233q6	208	25	externalised	externalise	VBN
cord-326228-9x1233q6	208	26	mtDNA	mtdna	NN
cord-326228-9x1233q6	208	27	to	to	TO
cord-326228-9x1233q6	208	28	participate	participate	VB
cord-326228-9x1233q6	208	29	in	in	IN
cord-326228-9x1233q6	208	30	NLRP3	nlrp3	NN
cord-326228-9x1233q6	208	31	signalling	signalling	NN
cord-326228-9x1233q6	208	32	,	,	,
cord-326228-9x1233q6	208	33	which	which	WDT
cord-326228-9x1233q6	208	34	then	then	RB
cord-326228-9x1233q6	208	35	drives	drive	VBZ
cord-326228-9x1233q6	208	36	further	further	RB
cord-326228-9x1233q6	208	37	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	208	38	damage	damage	NN
cord-326228-9x1233q6	208	39	.	.	.
cord-326228-9x1233q6	209	1	In	in	IN
cord-326228-9x1233q6	209	2	line	line	NN
cord-326228-9x1233q6	209	3	with	with	IN
cord-326228-9x1233q6	209	4	this	this	DT
cord-326228-9x1233q6	209	5	,	,	,
cord-326228-9x1233q6	209	6	one	one	CD
cord-326228-9x1233q6	209	7	study	study	NN
cord-326228-9x1233q6	209	8	examining	examine	VBG
cord-326228-9x1233q6	209	9	temporal	temporal	JJ
cord-326228-9x1233q6	209	10	changes	change	NNS
cord-326228-9x1233q6	209	11	in	in	IN
cord-326228-9x1233q6	209	12	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	209	13	stability	stability	NN
cord-326228-9x1233q6	209	14	during	during	IN
cord-326228-9x1233q6	209	15	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	209	16	activation	activation	NN
cord-326228-9x1233q6	209	17	reported	report	VBD
cord-326228-9x1233q6	209	18	that	that	IN
cord-326228-9x1233q6	209	19	LPS	LPS	NNP
cord-326228-9x1233q6	209	20	-	-	HYPH
cord-326228-9x1233q6	209	21	primed	prime	VBN
cord-326228-9x1233q6	209	22	BMDMs	bmdm	NNS
cord-326228-9x1233q6	209	23	treated	treat	VBN
cord-326228-9x1233q6	209	24	with	with	IN
cord-326228-9x1233q6	209	25	ATP	ATP	NNP
cord-326228-9x1233q6	209	26	or	or	CC
cord-326228-9x1233q6	209	27	nigericin	nigericin	NNS
cord-326228-9x1233q6	209	28	exhibited	exhibit	VBD
cord-326228-9x1233q6	209	29	some	some	DT
cord-326228-9x1233q6	209	30	inflammasome	inflammasome	NN
cord-326228-9x1233q6	209	31	-	-	HYPH
cord-326228-9x1233q6	209	32	independent	independent	JJ
cord-326228-9x1233q6	209	33	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	209	34	hyperpolarisation	hyperpolarisation	NN
cord-326228-9x1233q6	209	35	at	at	IN
cord-326228-9x1233q6	209	36	early	early	JJ
cord-326228-9x1233q6	209	37	time	time	NN
cord-326228-9x1233q6	209	38	points	point	NNS
cord-326228-9x1233q6	209	39	(	(	-LRB-
cord-326228-9x1233q6	209	40	up	up	IN
cord-326228-9x1233q6	209	41	to	to	TO
cord-326228-9x1233q6	209	42	15	15	CD
cord-326228-9x1233q6	209	43	min	min	NN
cord-326228-9x1233q6	209	44	post	post	NN
cord-326228-9x1233q6	209	45	treatment	treatment	NN
cord-326228-9x1233q6	209	46	)	)	-RRB-
cord-326228-9x1233q6	209	47	.	.	.
cord-326228-9x1233q6	210	1	At	at	IN
cord-326228-9x1233q6	210	2	later	later	JJ
cord-326228-9x1233q6	210	3	time	time	NN
cord-326228-9x1233q6	210	4	points	point	NNS
cord-326228-9x1233q6	210	5	(	(	-LRB-
cord-326228-9x1233q6	210	6	0.5	0.5	CD
cord-326228-9x1233q6	210	7	-	-	SYM
cord-326228-9x1233q6	210	8	1	1	CD
cord-326228-9x1233q6	210	9	h	h	NN
cord-326228-9x1233q6	210	10	)	)	-RRB-
cord-326228-9x1233q6	210	11	,	,	,
cord-326228-9x1233q6	210	12	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	210	13	underwent	undergo	VBD
cord-326228-9x1233q6	210	14	depolarisation	depolarisation	NN
cord-326228-9x1233q6	210	15	,	,	,
cord-326228-9x1233q6	210	16	and	and	CC
cord-326228-9x1233q6	210	17	this	this	DT
cord-326228-9x1233q6	210	18	was	be	VBD
cord-326228-9x1233q6	210	19	largely	largely	RB
cord-326228-9x1233q6	210	20	driven	drive	VBN
cord-326228-9x1233q6	210	21	by	by	IN
cord-326228-9x1233q6	210	22	NLRP3	nlrp3	NN
cord-326228-9x1233q6	210	23	and	and	CC
cord-326228-9x1233q6	210	24	caspase-1	caspase-1	NNP
cord-326228-9x1233q6	210	25	.	.	.
cord-326228-9x1233q6	211	1	80	80	CD
cord-326228-9x1233q6	212	1	The	the	DT
cord-326228-9x1233q6	212	2	active	active	JJ
cord-326228-9x1233q6	212	3	N	n	CD
cord-326228-9x1233q6	212	4	-	-	HYPH
cord-326228-9x1233q6	212	5	terminal	terminal	NN
cord-326228-9x1233q6	212	6	fragment	fragment	NN
cord-326228-9x1233q6	212	7	of	of	IN
cord-326228-9x1233q6	212	8	GSDMD	GSDMD	NNP
cord-326228-9x1233q6	212	9	has	have	VBZ
cord-326228-9x1233q6	212	10	affinity	affinity	NN
cord-326228-9x1233q6	212	11	for	for	IN
cord-326228-9x1233q6	212	12	the	the	DT
cord-326228-9x1233q6	212	13	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	212	14	lipid	lipid	NN
cord-326228-9x1233q6	212	15	cardiolipin	cardiolipin	NNP
cord-326228-9x1233q6	212	16	,	,	,
cord-326228-9x1233q6	212	17	5	5	CD
cord-326228-9x1233q6	212	18	and	and	CC
cord-326228-9x1233q6	212	19	so	so	RB
cord-326228-9x1233q6	212	20	it	-PRON-	PRP
cord-326228-9x1233q6	212	21	is	be	VBZ
cord-326228-9x1233q6	212	22	possible	possible	JJ
cord-326228-9x1233q6	212	23	that	that	IN
cord-326228-9x1233q6	212	24	GSDMD	GSDMD	NNP
cord-326228-9x1233q6	212	25	perforates	perforate	VBZ
cord-326228-9x1233q6	212	26	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	212	27	downstream	downstream	RB
cord-326228-9x1233q6	212	28	of	of	IN
cord-326228-9x1233q6	212	29	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	212	30	activation	activation	NN
cord-326228-9x1233q6	212	31	.	.	.
cord-326228-9x1233q6	213	1	Sterile	sterile	JJ
cord-326228-9x1233q6	213	2	-	-	HYPH
cord-326228-9x1233q6	213	3	alpha	alpha	NN
cord-326228-9x1233q6	213	4	and	and	CC
cord-326228-9x1233q6	213	5	armadillo	armadillo	NN
cord-326228-9x1233q6	213	6	motif	motif	NN
cord-326228-9x1233q6	213	7	-	-	HYPH
cord-326228-9x1233q6	213	8	containing	contain	VBG
cord-326228-9x1233q6	213	9	protein	protein	NN
cord-326228-9x1233q6	213	10	(	(	-LRB-
cord-326228-9x1233q6	213	11	SARM	SARM	NNP
cord-326228-9x1233q6	213	12	)	)	-RRB-
cord-326228-9x1233q6	213	13	,	,	,
cord-326228-9x1233q6	213	14	a	a	DT
cord-326228-9x1233q6	213	15	mitochondrially	mitochondrially	RB
cord-326228-9x1233q6	213	16	localised	localise	VBN
cord-326228-9x1233q6	213	17	TLR	TLR	NNP
cord-326228-9x1233q6	213	18	adaptor	adaptor	NN
cord-326228-9x1233q6	213	19	,	,	,
cord-326228-9x1233q6	213	20	is	be	VBZ
cord-326228-9x1233q6	213	21	also	also	RB
cord-326228-9x1233q6	213	22	required	require	VBN
cord-326228-9x1233q6	213	23	for	for	IN
cord-326228-9x1233q6	213	24	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	213	25	membrane	membrane	NN
cord-326228-9x1233q6	213	26	depolarisation	depolarisation	NN
cord-326228-9x1233q6	213	27	and	and	CC
cord-326228-9x1233q6	213	28	pyroptosis	pyroptosis	NN
cord-326228-9x1233q6	213	29	downstream	downstream	RB
cord-326228-9x1233q6	213	30	of	of	IN
cord-326228-9x1233q6	213	31	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	213	32	activation	activation	NN
cord-326228-9x1233q6	213	33	in	in	IN
cord-326228-9x1233q6	213	34	immortalised	immortalise	VBN
cord-326228-9x1233q6	213	35	mouse	mouse	NN
cord-326228-9x1233q6	213	36	macrophages	macrophage	NNS
cord-326228-9x1233q6	213	37	(	(	-LRB-
cord-326228-9x1233q6	213	38	iBMDMs	ibmdms	NN
cord-326228-9x1233q6	213	39	)	)	-RRB-
cord-326228-9x1233q6	213	40	,	,	,
cord-326228-9x1233q6	213	41	81	81	CD
cord-326228-9x1233q6	213	42	through	through	IN
cord-326228-9x1233q6	213	43	yetundetermined	yetundetermine	VBN
cord-326228-9x1233q6	213	44	mechanisms	mechanism	NNS
cord-326228-9x1233q6	213	45	.	.	.
cord-326228-9x1233q6	214	1	Regardless	regardless	RB
cord-326228-9x1233q6	214	2	of	of	IN
cord-326228-9x1233q6	214	3	which	which	WDT
cord-326228-9x1233q6	214	4	of	of	IN
cord-326228-9x1233q6	214	5	the	the	DT
cord-326228-9x1233q6	214	6	above	above	JJ
cord-326228-9x1233q6	214	7	models	model	NNS
cord-326228-9x1233q6	214	8	is	be	VBZ
cord-326228-9x1233q6	214	9	accurate	accurate	JJ
cord-326228-9x1233q6	214	10	,	,	,
cord-326228-9x1233q6	214	11	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	214	12	permeabilisation	permeabilisation	NN
cord-326228-9x1233q6	214	13	must	must	MD
cord-326228-9x1233q6	214	14	precede	precede	VB
cord-326228-9x1233q6	214	15	the	the	DT
cord-326228-9x1233q6	214	16	liberation	liberation	NN
cord-326228-9x1233q6	214	17	of	of	IN
cord-326228-9x1233q6	214	18	mtDNA	mtdna	NN
cord-326228-9x1233q6	214	19	to	to	IN
cord-326228-9x1233q6	214	20	the	the	DT
cord-326228-9x1233q6	214	21	cytosol	cytosol	NN
cord-326228-9x1233q6	214	22	.	.	.
cord-326228-9x1233q6	215	1	Currently	currently	RB
cord-326228-9x1233q6	215	2	,	,	,
cord-326228-9x1233q6	215	3	the	the	DT
cord-326228-9x1233q6	215	4	field	field	NN
cord-326228-9x1233q6	215	5	is	be	VBZ
cord-326228-9x1233q6	215	6	yet	yet	RB
cord-326228-9x1233q6	215	7	to	to	TO
cord-326228-9x1233q6	215	8	reach	reach	VB
cord-326228-9x1233q6	215	9	a	a	DT
cord-326228-9x1233q6	215	10	consensus	consensus	NN
cord-326228-9x1233q6	215	11	on	on	IN
cord-326228-9x1233q6	215	12	mechanisms	mechanism	NNS
cord-326228-9x1233q6	215	13	mediating	mediate	VBG
cord-326228-9x1233q6	215	14	the	the	DT
cord-326228-9x1233q6	215	15	permeabilisation	permeabilisation	NN
cord-326228-9x1233q6	215	16	of	of	IN
cord-326228-9x1233q6	215	17	the	the	DT
cord-326228-9x1233q6	215	18	two	two	CD
cord-326228-9x1233q6	215	19	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	215	20	membranes	membrane	NNS
cord-326228-9x1233q6	215	21	that	that	WDT
cord-326228-9x1233q6	215	22	envelop	envelop	VBP
cord-326228-9x1233q6	215	23	mtDNA	mtdna	JJ
cord-326228-9x1233q6	215	24	.	.	.
cord-326228-9x1233q6	216	1	We	-PRON-	PRP
cord-326228-9x1233q6	216	2	pose	pose	VBP
cord-326228-9x1233q6	216	3	several	several	JJ
cord-326228-9x1233q6	216	4	hypotheses	hypothesis	NNS
cord-326228-9x1233q6	216	5	for	for	IN
cord-326228-9x1233q6	216	6	mechanisms	mechanism	NNS
cord-326228-9x1233q6	216	7	by	by	IN
cord-326228-9x1233q6	216	8	which	which	WDT
cord-326228-9x1233q6	216	9	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	216	10	may	may	MD
cord-326228-9x1233q6	216	11	directly	directly	RB
cord-326228-9x1233q6	216	12	or	or	CC
cord-326228-9x1233q6	216	13	indirectly	indirectly	RB
cord-326228-9x1233q6	216	14	drive	drive	VB
cord-326228-9x1233q6	216	15	NLRP3	nlrp3	NN
cord-326228-9x1233q6	216	16	signalling	signal	VBG
cord-326228-9x1233q6	216	17	in	in	IN
cord-326228-9x1233q6	216	18	Figures	figure	NNS
cord-326228-9x1233q6	216	19	2	2	CD
cord-326228-9x1233q6	216	20	and	and	CC
cord-326228-9x1233q6	216	21	 	 	_SP
cord-326228-9x1233q6	216	22	3	3	CD
cord-326228-9x1233q6	216	23	.	.	.
cord-326228-9x1233q6	217	1	Until	until	IN
cord-326228-9x1233q6	217	2	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	217	3	perforation	perforation	NN
cord-326228-9x1233q6	217	4	mechanisms	mechanism	NNS
cord-326228-9x1233q6	217	5	are	be	VBP
cord-326228-9x1233q6	217	6	discovered	discover	VBN
cord-326228-9x1233q6	217	7	,	,	,
cord-326228-9x1233q6	217	8	the	the	DT
cord-326228-9x1233q6	217	9	true	true	JJ
cord-326228-9x1233q6	217	10	biology	biology	NN
cord-326228-9x1233q6	217	11	may	may	MD
cord-326228-9x1233q6	217	12	remain	remain	VB
cord-326228-9x1233q6	217	13	elusive	elusive	JJ
cord-326228-9x1233q6	217	14	.	.	.
cord-326228-9x1233q6	218	1	Cyclic	cyclic	JJ
cord-326228-9x1233q6	218	2	GMP	GMP	NNP
cord-326228-9x1233q6	218	3	-	-	HYPH
cord-326228-9x1233q6	218	4	AMP	AMP	NNP
cord-326228-9x1233q6	218	5	synthase	synthase	NN
cord-326228-9x1233q6	218	6	recognises	recognise	VBZ
cord-326228-9x1233q6	218	7	pathogenand	pathogenand	JJ
cord-326228-9x1233q6	218	8	host	host	NN
cord-326228-9x1233q6	218	9	-	-	HYPH
cord-326228-9x1233q6	218	10	derived	derive	VBN
cord-326228-9x1233q6	218	11	dsDNA	dsdna	RB
cord-326228-9x1233q6	218	12	and	and	CC
cord-326228-9x1233q6	218	13	signals	signal	NNS
cord-326228-9x1233q6	218	14	to	to	TO
cord-326228-9x1233q6	218	15	promote	promote	VB
cord-326228-9x1233q6	218	16	antiviral	antiviral	JJ
cord-326228-9x1233q6	218	17	,	,	,
cord-326228-9x1233q6	218	18	antitumor	antitumor	NN
cord-326228-9x1233q6	218	19	and	and	CC
cord-326228-9x1233q6	218	20	cell	cell	NN
cord-326228-9x1233q6	218	21	senescence	senescence	NN
cord-326228-9x1233q6	218	22	pathways	pathway	NNS
cord-326228-9x1233q6	218	23	.	.	.
cord-326228-9x1233q6	219	1	82	82	CD
cord-326228-9x1233q6	219	2	Activated	Activated	NNP
cord-326228-9x1233q6	219	3	cGAS	cgas	NN
cord-326228-9x1233q6	219	4	produces	produce	VBZ
cord-326228-9x1233q6	219	5	the	the	DT
cord-326228-9x1233q6	219	6	second	second	JJ
cord-326228-9x1233q6	219	7	messenger	messenger	NN
cord-326228-9x1233q6	219	8	,	,	,
cord-326228-9x1233q6	219	9	cyclic	cyclic	JJ
cord-326228-9x1233q6	219	10	GMP	GMP	NNP
cord-326228-9x1233q6	219	11	-	-	HYPH
cord-326228-9x1233q6	219	12	AMP	AMP	NNP
cord-326228-9x1233q6	219	13	(	(	-LRB-
cord-326228-9x1233q6	219	14	cGAMP	cGAMP	NNP
cord-326228-9x1233q6	219	15	)	)	-RRB-
cord-326228-9x1233q6	219	16	,	,	,
cord-326228-9x1233q6	219	17	that	that	WDT
cord-326228-9x1233q6	219	18	binds	bind	VBZ
cord-326228-9x1233q6	219	19	to	to	IN
cord-326228-9x1233q6	219	20	STING	sting	VB
cord-326228-9x1233q6	219	21	.	.	.
cord-326228-9x1233q6	220	1	STING	STING	NNP
cord-326228-9x1233q6	220	2	translocates	translocate	NNS
cord-326228-9x1233q6	220	3	from	from	IN
cord-326228-9x1233q6	220	4	the	the	DT
cord-326228-9x1233q6	220	5	ER	ER	NNP
cord-326228-9x1233q6	220	6	to	to	IN
cord-326228-9x1233q6	220	7	the	the	DT
cord-326228-9x1233q6	220	8	Golgi	Golgi	NNP
cord-326228-9x1233q6	220	9	to	to	TO
cord-326228-9x1233q6	220	10	activate	activate	VB
cord-326228-9x1233q6	220	11	IRF3	IRF3	NNP
cord-326228-9x1233q6	220	12	,	,	,
cord-326228-9x1233q6	220	13	TANK	tank	NN
cord-326228-9x1233q6	220	14	-	-	HYPH
cord-326228-9x1233q6	220	15	binding	binding	NN
cord-326228-9x1233q6	220	16	kinase	kinase	NN
cord-326228-9x1233q6	220	17	(	(	-LRB-
cord-326228-9x1233q6	220	18	TBK1	TBK1	NNP
cord-326228-9x1233q6	220	19	)	)	-RRB-
cord-326228-9x1233q6	220	20	and	and	CC
cord-326228-9x1233q6	220	21	NF	nf	NN
cord-326228-9x1233q6	220	22	-	-	HYPH
cord-326228-9x1233q6	220	23	jB	jb	NN
cord-326228-9x1233q6	220	24	to	to	TO
cord-326228-9x1233q6	220	25	drive	drive	VB
cord-326228-9x1233q6	220	26	transcriptional	transcriptional	JJ
cord-326228-9x1233q6	220	27	upregulation	upregulation	NN
cord-326228-9x1233q6	220	28	of	of	IN
cord-326228-9x1233q6	220	29	type	type	NN
cord-326228-9x1233q6	220	30	I	-PRON-	PRP
cord-326228-9x1233q6	220	31	IFNs	ifns	VBP
cord-326228-9x1233q6	220	32	.	.	.
cord-326228-9x1233q6	221	1	83	83	CD
cord-326228-9x1233q6	222	1	Host	host	NN
cord-326228-9x1233q6	222	2	mtDNA	mtdna	NN
cord-326228-9x1233q6	222	3	is	be	VBZ
cord-326228-9x1233q6	222	4	recognised	recognise	VBN
cord-326228-9x1233q6	222	5	by	by	IN
cord-326228-9x1233q6	222	6	cGAS	cga	VBG
cord-326228-9x1233q6	222	7	to	to	TO
cord-326228-9x1233q6	222	8	drive	drive	VB
cord-326228-9x1233q6	222	9	cGAMP	cGAMP	NNP
cord-326228-9x1233q6	222	10	/	/	SYM
cord-326228-9x1233q6	222	11	STING	sting	NN
cord-326228-9x1233q6	222	12	-	-	HYPH
cord-326228-9x1233q6	222	13	mediated	mediate	VBN
cord-326228-9x1233q6	222	14	IFN	IFN	NNP
cord-326228-9x1233q6	222	15	-	-	HYPH
cord-326228-9x1233q6	222	16	b	b	NN
cord-326228-9x1233q6	222	17	antiviral	antiviral	JJ
cord-326228-9x1233q6	222	18	signalling	signalling	NN
cord-326228-9x1233q6	222	19	.	.	.
cord-326228-9x1233q6	223	1	82	82	CD
cord-326228-9x1233q6	223	2	,	,	,
cord-326228-9x1233q6	223	3	[	[	-LRB-
cord-326228-9x1233q6	223	4	84	84	CD
cord-326228-9x1233q6	223	5	]	]	-RRB-
cord-326228-9x1233q6	223	6	[	[	-LRB-
cord-326228-9x1233q6	223	7	85	85	CD
cord-326228-9x1233q6	223	8	]	]	-RRB-
cord-326228-9x1233q6	223	9	[	[	-LRB-
cord-326228-9x1233q6	223	10	86	86	CD
cord-326228-9x1233q6	223	11	]	]	-RRB-
cord-326228-9x1233q6	224	1	While	while	IN
cord-326228-9x1233q6	224	2	AIM2	AIM2	NNP
cord-326228-9x1233q6	224	3	inflammasome	inflammasome	NN
cord-326228-9x1233q6	224	4	activation	activation	NN
cord-326228-9x1233q6	224	5	inhibits	inhibit	VBZ
cord-326228-9x1233q6	224	6	cGAS	cgas	NN
cord-326228-9x1233q6	224	7	signalling	signalling	NN
cord-326228-9x1233q6	224	8	via	via	IN
cord-326228-9x1233q6	224	9	GSDMDdependent	GSDMDdependent	NNP
cord-326228-9x1233q6	224	10	K	k	NN
cord-326228-9x1233q6	224	11	+	+	CC
cord-326228-9x1233q6	224	12	efflux	efflux	NN
cord-326228-9x1233q6	224	13	,	,	,
cord-326228-9x1233q6	224	14	87	87	CD
cord-326228-9x1233q6	224	15	cGAS	cgas	NN
cord-326228-9x1233q6	224	16	/	/	SYM
cord-326228-9x1233q6	224	17	STING	sting	NN
cord-326228-9x1233q6	224	18	-	-	HYPH
cord-326228-9x1233q6	224	19	dependent	dependent	JJ
cord-326228-9x1233q6	224	20	NF	nf	NN
cord-326228-9x1233q6	224	21	-	-	HYPH
cord-326228-9x1233q6	224	22	jB	jb	NN
cord-326228-9x1233q6	224	23	activation	activation	NN
cord-326228-9x1233q6	224	24	may	may	MD
cord-326228-9x1233q6	224	25	provide	provide	VB
cord-326228-9x1233q6	224	26	a	a	DT
cord-326228-9x1233q6	224	27	signal	signal	NN
cord-326228-9x1233q6	224	28	1	1	CD
cord-326228-9x1233q6	224	29	for	for	IN
cord-326228-9x1233q6	224	30	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	224	31	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	224	32	activation	activation	NN
cord-326228-9x1233q6	224	33	.	.	.
cord-326228-9x1233q6	225	1	cGAS	cgas	JJ
cord-326228-9x1233q6	225	2	/	/	SYM
cord-326228-9x1233q6	225	3	STING	sting	NN
cord-326228-9x1233q6	225	4	signalling	signalling	NN
cord-326228-9x1233q6	225	5	may	may	MD
cord-326228-9x1233q6	225	6	also	also	RB
cord-326228-9x1233q6	225	7	be	be	VB
cord-326228-9x1233q6	225	8	a	a	DT
cord-326228-9x1233q6	225	9	downstream	downstream	JJ
cord-326228-9x1233q6	225	10	consequence	consequence	NN
cord-326228-9x1233q6	225	11	of	of	IN
cord-326228-9x1233q6	225	12	NLRP3	nlrp3	NN
cord-326228-9x1233q6	225	13	activation	activation	NN
cord-326228-9x1233q6	225	14	;	;	:
cord-326228-9x1233q6	225	15	for	for	IN
cord-326228-9x1233q6	225	16	example	example	NN
cord-326228-9x1233q6	225	17	,	,	,
cord-326228-9x1233q6	225	18	IL-1R	IL-1R	NNP
cord-326228-9x1233q6	225	19	signalling	signal	VBG
cord-326228-9x1233q6	225	20	in	in	IN
cord-326228-9x1233q6	225	21	the	the	DT
cord-326228-9x1233q6	225	22	human	human	JJ
cord-326228-9x1233q6	225	23	THP-1	THP-1	NNP
cord-326228-9x1233q6	225	24	myeloid	myeloid	JJ
cord-326228-9x1233q6	225	25	cell	cell	NN
cord-326228-9x1233q6	225	26	line	line	NN
cord-326228-9x1233q6	225	27	drives	drive	VBZ
cord-326228-9x1233q6	225	28	loss	loss	NN
cord-326228-9x1233q6	225	29	of	of	IN
cord-326228-9x1233q6	225	30	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	225	31	membrane	membrane	NN
cord-326228-9x1233q6	225	32	potential	potential	NN
cord-326228-9x1233q6	225	33	and	and	CC
cord-326228-9x1233q6	225	34	recognition	recognition	NN
cord-326228-9x1233q6	225	35	of	of	IN
cord-326228-9x1233q6	225	36	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	225	37	by	by	IN
cord-326228-9x1233q6	225	38	cGAS	cgas	NN
cord-326228-9x1233q6	225	39	.	.	.
cord-326228-9x1233q6	225	40	86	86	CD
cord-326228-9x1233q6	225	41	Deficiency	deficiency	NN
cord-326228-9x1233q6	225	42	in	in	IN
cord-326228-9x1233q6	225	43	the	the	DT
cord-326228-9x1233q6	225	44	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	225	45	transcription	transcription	NN
cord-326228-9x1233q6	225	46	factor	factor	NN
cord-326228-9x1233q6	225	47	,	,	,
cord-326228-9x1233q6	225	48	TFAM	TFAM	NNP
cord-326228-9x1233q6	225	49	,	,	,
cord-326228-9x1233q6	225	50	also	also	RB
cord-326228-9x1233q6	225	51	drives	drive	VBZ
cord-326228-9x1233q6	225	52	mtDNA	mtdna	JJ
cord-326228-9x1233q6	225	53	mislocalisation	mislocalisation	NN
cord-326228-9x1233q6	225	54	to	to	IN
cord-326228-9x1233q6	225	55	the	the	DT
cord-326228-9x1233q6	225	56	cytosol	cytosol	NN
cord-326228-9x1233q6	225	57	and	and	CC
cord-326228-9x1233q6	225	58	resultant	resultant	JJ
cord-326228-9x1233q6	225	59	cGAS	cgas	NN
cord-326228-9x1233q6	225	60	activation	activation	NN
cord-326228-9x1233q6	225	61	in	in	IN
cord-326228-9x1233q6	225	62	mouse	mouse	NN
cord-326228-9x1233q6	225	63	embryonic	embryonic	JJ
cord-326228-9x1233q6	225	64	fibroblasts	fibroblast	NNS
cord-326228-9x1233q6	225	65	(	(	-LRB-
cord-326228-9x1233q6	225	66	MEFs	mef	NNS
cord-326228-9x1233q6	225	67	)	)	-RRB-
cord-326228-9x1233q6	225	68	and	and	CC
cord-326228-9x1233q6	225	69	BMDMs	bmdm	NNS
cord-326228-9x1233q6	225	70	.	.	.
cord-326228-9x1233q6	226	1	85	85	CD
cord-326228-9x1233q6	227	1	When	when	WRB
cord-326228-9x1233q6	227	2	caspases	caspase	NNS
cord-326228-9x1233q6	227	3	are	be	VBP
cord-326228-9x1233q6	227	4	inhibited	inhibit	VBN
cord-326228-9x1233q6	227	5	in	in	IN
cord-326228-9x1233q6	227	6	apoptotic	apoptotic	JJ
cord-326228-9x1233q6	227	7	MEFs	mef	NNS
cord-326228-9x1233q6	227	8	,	,	,
cord-326228-9x1233q6	227	9	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	227	10	is	be	VBZ
cord-326228-9x1233q6	227	11	liberated	liberate	VBN
cord-326228-9x1233q6	227	12	from	from	IN
cord-326228-9x1233q6	227	13	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	227	14	by	by	IN
cord-326228-9x1233q6	227	15	BAX	BAX	NNP
cord-326228-9x1233q6	227	16	/	/	SYM
cord-326228-9x1233q6	227	17	BAK	BAK	NNP
cord-326228-9x1233q6	227	18	macropores	macropore	NNS
cord-326228-9x1233q6	227	19	and	and	CC
cord-326228-9x1233q6	227	20	is	be	VBZ
cord-326228-9x1233q6	227	21	recognised	recognise	VBN
cord-326228-9x1233q6	227	22	by	by	IN
cord-326228-9x1233q6	227	23	cGAS	cgas	NN
cord-326228-9x1233q6	227	24	.	.	.
cord-326228-9x1233q6	227	25	84	84	CD
cord-326228-9x1233q6	227	26	cGAS	cgas	JJ
cord-326228-9x1233q6	227	27	/	/	SYM
cord-326228-9x1233q6	227	28	STING	sting	NN
cord-326228-9x1233q6	227	29	is	be	VBZ
cord-326228-9x1233q6	227	30	linked	link	VBN
cord-326228-9x1233q6	227	31	to	to	IN
cord-326228-9x1233q6	227	32	pathology	pathology	NN
cord-326228-9x1233q6	227	33	in	in	IN
cord-326228-9x1233q6	227	34	Prkn	Prkn	NNP
cord-326228-9x1233q6	227	35	À	À	NNP
cord-326228-9x1233q6	227	36	/	/	SYM
cord-326228-9x1233q6	227	37	À	à	NN
cord-326228-9x1233q6	227	38	mice	mouse	NNS
cord-326228-9x1233q6	227	39	(	(	-LRB-
cord-326228-9x1233q6	227	40	a	a	DT
cord-326228-9x1233q6	227	41	model	model	NN
cord-326228-9x1233q6	227	42	for	for	IN
cord-326228-9x1233q6	227	43	human	human	JJ
cord-326228-9x1233q6	227	44	PRKN	PRKN	NNP
cord-326228-9x1233q6	227	45	gene	gene	NN
cord-326228-9x1233q6	227	46	-	-	HYPH
cord-326228-9x1233q6	227	47	associated	associate	VBN
cord-326228-9x1233q6	227	48	Parkinson	Parkinson	NNP
cord-326228-9x1233q6	227	49	's	's	POS
cord-326228-9x1233q6	227	50	disease	disease	NN
cord-326228-9x1233q6	227	51	)	)	-RRB-
cord-326228-9x1233q6	227	52	,	,	,
cord-326228-9x1233q6	227	53	which	which	WDT
cord-326228-9x1233q6	227	54	exhibited	exhibit	VBD
cord-326228-9x1233q6	227	55	higher	high	JJR
cord-326228-9x1233q6	227	56	circulating	circulate	VBG
cord-326228-9x1233q6	227	57	cell	cell	NN
cord-326228-9x1233q6	227	58	-	-	HYPH
cord-326228-9x1233q6	227	59	free	free	JJ
cord-326228-9x1233q6	227	60	mtDNA	mtdna	NN
cord-326228-9x1233q6	227	61	(	(	-LRB-
cord-326228-9x1233q6	227	62	normalised	normalise	VBN
cord-326228-9x1233q6	227	63	to	to	IN
cord-326228-9x1233q6	227	64	genomic	genomic	JJ
cord-326228-9x1233q6	227	65	DNA	dna	NN
cord-326228-9x1233q6	227	66	)	)	-RRB-
cord-326228-9x1233q6	227	67	than	than	IN
cord-326228-9x1233q6	227	68	healthy	healthy	JJ
cord-326228-9x1233q6	227	69	wildtype	wildtype	NN
cord-326228-9x1233q6	227	70	mice	mouse	NNS
cord-326228-9x1233q6	227	71	,	,	,
cord-326228-9x1233q6	227	72	and	and	CC
cord-326228-9x1233q6	227	73	STING	sting	NN
cord-326228-9x1233q6	227	74	-	-	HYPH
cord-326228-9x1233q6	227	75	dependent	dependent	JJ
cord-326228-9x1233q6	227	76	elevations	elevation	NNS
cord-326228-9x1233q6	227	77	in	in	IN
cord-326228-9x1233q6	227	78	serum	serum	NN
cord-326228-9x1233q6	227	79	IL-6	IL-6	NNP
cord-326228-9x1233q6	227	80	and	and	CC
cord-326228-9x1233q6	227	81	IFN	IFN	NNP
cord-326228-9x1233q6	227	82	-	-	HYPH
cord-326228-9x1233q6	227	83	b	b	NN
cord-326228-9x1233q6	227	84	levels	level	NNS
cord-326228-9x1233q6	227	85	.	.	.
cord-326228-9x1233q6	228	1	88	88	CD
cord-326228-9x1233q6	229	1	The	the	DT
cord-326228-9x1233q6	229	2	cGAS	cgas	JJ
cord-326228-9x1233q6	229	3	/	/	SYM
cord-326228-9x1233q6	229	4	STING	sting	NN
cord-326228-9x1233q6	229	5	pathway	pathway	NN
cord-326228-9x1233q6	229	6	also	also	RB
cord-326228-9x1233q6	229	7	promotes	promote	VBZ
cord-326228-9x1233q6	229	8	NLRP3	nlrp3	NN
cord-326228-9x1233q6	229	9	and	and	CC
cord-326228-9x1233q6	229	10	AIM2	AIM2	NNP
cord-326228-9x1233q6	229	11	activation	activation	NN
cord-326228-9x1233q6	229	12	in	in	IN
cord-326228-9x1233q6	229	13	murine	murine	JJ
cord-326228-9x1233q6	229	14	macrophages	macrophage	NNS
cord-326228-9x1233q6	229	15	.	.	.
cord-326228-9x1233q6	230	1	89	89	CD
cord-326228-9x1233q6	231	1	Cytosolic	Cytosolic	NNP
cord-326228-9x1233q6	231	2	DNA	dna	NN
cord-326228-9x1233q6	231	3	-	-	HYPH
cord-326228-9x1233q6	231	4	induced	induce	VBN
cord-326228-9x1233q6	231	5	cGAS	cgas	NN
cord-326228-9x1233q6	231	6	/	/	SYM
cord-326228-9x1233q6	231	7	STING	sting	VB
cord-326228-9x1233q6	231	8	signalling	signalling	NN
cord-326228-9x1233q6	231	9	triggers	trigger	NNS
cord-326228-9x1233q6	231	10	lysosomal	lysosomal	JJ
cord-326228-9x1233q6	231	11	rupture	rupture	NN
cord-326228-9x1233q6	231	12	(	(	-LRB-
cord-326228-9x1233q6	231	13	signal	signal	NNP
cord-326228-9x1233q6	231	14	2	2	CD
cord-326228-9x1233q6	231	15	)	)	-RRB-
cord-326228-9x1233q6	231	16	,	,	,
cord-326228-9x1233q6	231	17	leading	lead	VBG
cord-326228-9x1233q6	231	18	to	to	IN
cord-326228-9x1233q6	231	19	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	231	20	activation	activation	NN
cord-326228-9x1233q6	231	21	in	in	IN
cord-326228-9x1233q6	231	22	human	human	JJ
cord-326228-9x1233q6	231	23	cells	cell	NNS
cord-326228-9x1233q6	231	24	.	.	.
cord-326228-9x1233q6	232	1	77	77	CD
cord-326228-9x1233q6	233	1	cGAS	cgas	JJ
cord-326228-9x1233q6	233	2	/	/	SYM
cord-326228-9x1233q6	233	3	STING	sting	NN
cord-326228-9x1233q6	233	4	-	-	HYPH
cord-326228-9x1233q6	233	5	mediated	mediate	VBN
cord-326228-9x1233q6	233	6	recognition	recognition	NN
cord-326228-9x1233q6	233	7	of	of	IN
cord-326228-9x1233q6	233	8	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	233	9	may	may	MD
cord-326228-9x1233q6	233	10	thereby	thereby	RB
cord-326228-9x1233q6	233	11	provide	provide	VB
cord-326228-9x1233q6	233	12	either	either	CC
cord-326228-9x1233q6	233	13	signal	signal	NN
cord-326228-9x1233q6	233	14	1	1	CD
cord-326228-9x1233q6	233	15	,	,	,
cord-326228-9x1233q6	233	16	signal	signal	NN
cord-326228-9x1233q6	233	17	2	2	CD
cord-326228-9x1233q6	233	18	,	,	,
cord-326228-9x1233q6	233	19	or	or	CC
cord-326228-9x1233q6	233	20	both	both	DT
cord-326228-9x1233q6	233	21	for	for	IN
cord-326228-9x1233q6	233	22	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	233	23	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	233	24	activation	activation	NN
cord-326228-9x1233q6	233	25	(	(	-LRB-
cord-326228-9x1233q6	233	26	Figure	Figure	NNP
cord-326228-9x1233q6	233	27	3a	3a	CD
cord-326228-9x1233q6	233	28	)	)	-RRB-
cord-326228-9x1233q6	233	29	.	.	.
cord-326228-9x1233q6	234	1	In	in	IN
cord-326228-9x1233q6	234	2	murine	murine	JJ
cord-326228-9x1233q6	234	3	macrophages	macrophage	NNS
cord-326228-9x1233q6	234	4	,	,	,
cord-326228-9x1233q6	234	5	active	active	JJ
cord-326228-9x1233q6	234	6	caspase-1	caspase-1	NNP
cord-326228-9x1233q6	234	7	cleaves	cleave	VBZ
cord-326228-9x1233q6	234	8	and	and	CC
cord-326228-9x1233q6	234	9	inactivates	inactivate	VBZ
cord-326228-9x1233q6	234	10	cGAS	cgas	NN
cord-326228-9x1233q6	234	11	,	,	,
cord-326228-9x1233q6	234	12	90	90	CD
cord-326228-9x1233q6	234	13	possibly	possibly	RB
cord-326228-9x1233q6	234	14	providing	provide	VBG
cord-326228-9x1233q6	234	15	a	a	DT
cord-326228-9x1233q6	234	16	mechanism	mechanism	NN
cord-326228-9x1233q6	234	17	for	for	IN
cord-326228-9x1233q6	234	18	switching	switch	VBG
cord-326228-9x1233q6	234	19	off	off	RP
cord-326228-9x1233q6	234	20	mtDNA	mtdna	NN
cord-326228-9x1233q6	234	21	-	-	HYPH
cord-326228-9x1233q6	234	22	induced	induce	VBN
cord-326228-9x1233q6	234	23	cGAS	cgas	NN
cord-326228-9x1233q6	234	24	/	/	SYM
cord-326228-9x1233q6	234	25	STING	sting	VB
cord-326228-9x1233q6	234	26	signalling	signal	VBG
cord-326228-9x1233q6	234	27	once	once	IN
cord-326228-9x1233q6	234	28	inflammasome	inflammasome	NN
cord-326228-9x1233q6	234	29	pathways	pathway	NNS
cord-326228-9x1233q6	234	30	are	be	VBP
cord-326228-9x1233q6	234	31	engaged	engage	VBN
cord-326228-9x1233q6	234	32	.	.	.
cord-326228-9x1233q6	235	1	Unmethylated	unmethylated	JJ
cord-326228-9x1233q6	235	2	CpG	cpg	NN
cord-326228-9x1233q6	235	3	DNA	DNA	NNP
cord-326228-9x1233q6	235	4	activates	activate	VBZ
cord-326228-9x1233q6	235	5	immune	immune	JJ
cord-326228-9x1233q6	235	6	cells	cell	NNS
cord-326228-9x1233q6	235	7	via	via	IN
cord-326228-9x1233q6	235	8	TLR9	TLR9	NNP
cord-326228-9x1233q6	235	9	.	.	.
cord-326228-9x1233q6	236	1	91	91	CD
cord-326228-9x1233q6	237	1	,	,	,
cord-326228-9x1233q6	237	2	92	92	CD
cord-326228-9x1233q6	237	3	TLR9	TLR9	NNP
cord-326228-9x1233q6	237	4	is	be	VBZ
cord-326228-9x1233q6	237	5	expressed	express	VBN
cord-326228-9x1233q6	237	6	in	in	IN
cord-326228-9x1233q6	237	7	murine	murine	JJ
cord-326228-9x1233q6	237	8	myeloidderived	myeloidderived	JJ
cord-326228-9x1233q6	237	9	cells	cell	NNS
cord-326228-9x1233q6	237	10	and	and	CC
cord-326228-9x1233q6	237	11	plasmacytoid	plasmacytoid	NNP
cord-326228-9x1233q6	237	12	dendritic	dendritic	JJ
cord-326228-9x1233q6	237	13	cells	cell	NNS
cord-326228-9x1233q6	237	14	(	(	-LRB-
cord-326228-9x1233q6	237	15	pDCs	pDCs	NNP
cord-326228-9x1233q6	237	16	)	)	-RRB-
cord-326228-9x1233q6	237	17	,	,	,
cord-326228-9x1233q6	237	18	but	but	CC
cord-326228-9x1233q6	237	19	is	be	VBZ
cord-326228-9x1233q6	237	20	primarily	primarily	RB
cord-326228-9x1233q6	237	21	expressed	express	VBN
cord-326228-9x1233q6	237	22	by	by	IN
cord-326228-9x1233q6	237	23	B	b	NN
cord-326228-9x1233q6	237	24	cells	cell	NNS
cord-326228-9x1233q6	237	25	and	and	CC
cord-326228-9x1233q6	237	26	pDCs	pdc	VBD
cord-326228-9x1233q6	237	27	in	in	IN
cord-326228-9x1233q6	237	28	humans	human	NNS
cord-326228-9x1233q6	237	29	.	.	.
cord-326228-9x1233q6	238	1	93	93	CD
cord-326228-9x1233q6	239	1	TLR9	TLR9	NNP
cord-326228-9x1233q6	239	2	recognises	recognise	VBZ
cord-326228-9x1233q6	239	3	unmethylated	unmethylate	VBN
cord-326228-9x1233q6	239	4	CpG	CpG	NNP
cord-326228-9x1233q6	239	5	in	in	IN
cord-326228-9x1233q6	239	6	the	the	DT
cord-326228-9x1233q6	239	7	endosomal	endosomal	NNP
cord-326228-9x1233q6	239	8	system	system	NN
cord-326228-9x1233q6	239	9	,	,	,
cord-326228-9x1233q6	239	10	94	94	CD
cord-326228-9x1233q6	239	11	,	,	,
cord-326228-9x1233q6	239	12	95	95	CD
cord-326228-9x1233q6	239	13	including	include	VBG
cord-326228-9x1233q6	239	14	that	that	DT
cord-326228-9x1233q6	239	15	of	of	IN
cord-326228-9x1233q6	239	16	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	239	17	origin	origin	NN
cord-326228-9x1233q6	239	18	following	follow	VBG
cord-326228-9x1233q6	239	19	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	239	20	disruption	disruption	NN
cord-326228-9x1233q6	239	21	.	.	.
cord-326228-9x1233q6	240	1	[	[	-LRB-
cord-326228-9x1233q6	240	2	96	96	CD
cord-326228-9x1233q6	240	3	]	]	-RRB-
cord-326228-9x1233q6	240	4	[	[	-LRB-
cord-326228-9x1233q6	240	5	97	97	CD
cord-326228-9x1233q6	240	6	]	]	-RRB-
cord-326228-9x1233q6	240	7	[	[	-LRB-
cord-326228-9x1233q6	240	8	98	98	CD
cord-326228-9x1233q6	240	9	]	]	-RRB-
cord-326228-9x1233q6	241	1	[	[	-LRB-
cord-326228-9x1233q6	241	2	99	99	CD
cord-326228-9x1233q6	241	3	]	]	-RRB-
cord-326228-9x1233q6	241	4	CpG	CpG	NNP
cord-326228-9x1233q6	241	5	recognition	recognition	NN
cord-326228-9x1233q6	241	6	by	by	IN
cord-326228-9x1233q6	241	7	TLR9	TLR9	NNP
cord-326228-9x1233q6	241	8	provides	provide	VBZ
cord-326228-9x1233q6	241	9	a	a	DT
cord-326228-9x1233q6	241	10	signal	signal	NN
cord-326228-9x1233q6	241	11	1	1	CD
cord-326228-9x1233q6	241	12	for	for	IN
cord-326228-9x1233q6	241	13	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	241	14	activation	activation	NN
cord-326228-9x1233q6	241	15	,	,	,
cord-326228-9x1233q6	241	16	transcriptionally	transcriptionally	RB
cord-326228-9x1233q6	241	17	upregulating	upregulate	VBG
cord-326228-9x1233q6	241	18	inflammasome	inflammasome	NN
cord-326228-9x1233q6	241	19	-	-	HYPH
cord-326228-9x1233q6	241	20	required	require	VBN
cord-326228-9x1233q6	241	21	genes	gene	NNS
cord-326228-9x1233q6	241	22	under	under	IN
cord-326228-9x1233q6	241	23	NF	nf	NN
cord-326228-9x1233q6	241	24	-	-	HYPH
cord-326228-9x1233q6	241	25	jB	jb	NN
cord-326228-9x1233q6	241	26	control	control	NN
cord-326228-9x1233q6	241	27	100	100	CD
cord-326228-9x1233q6	241	28	,	,	,
cord-326228-9x1233q6	241	29	101	101	CD
cord-326228-9x1233q6	241	30	(	(	-LRB-
cord-326228-9x1233q6	241	31	Figure	figure	NN
cord-326228-9x1233q6	241	32	3b	3b	CD
cord-326228-9x1233q6	241	33	)	)	-RRB-
cord-326228-9x1233q6	241	34	.	.	.
cord-326228-9x1233q6	242	1	The	the	DT
cord-326228-9x1233q6	242	2	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	242	3	dynamics	dynamic	NNS
cord-326228-9x1233q6	242	4	that	that	WDT
cord-326228-9x1233q6	242	5	drive	drive	VBP
cord-326228-9x1233q6	242	6	disruption	disruption	NN
cord-326228-9x1233q6	242	7	and	and	CC
cord-326228-9x1233q6	242	8	exposure	exposure	NN
cord-326228-9x1233q6	242	9	of	of	IN
cord-326228-9x1233q6	242	10	mtDNA	mtdna	NN
cord-326228-9x1233q6	242	11	to	to	IN
cord-326228-9x1233q6	242	12	TLR9	TLR9	NNP
cord-326228-9x1233q6	242	13	are	be	VBP
cord-326228-9x1233q6	242	14	varied	varied	JJ
cord-326228-9x1233q6	242	15	and	and	CC
cord-326228-9x1233q6	242	16	unclear	unclear	JJ
cord-326228-9x1233q6	242	17	,	,	,
cord-326228-9x1233q6	242	18	yet	yet	CC
cord-326228-9x1233q6	242	19	some	some	DT
cord-326228-9x1233q6	242	20	evidence	evidence	NN
cord-326228-9x1233q6	242	21	implicates	implicate	VBZ
cord-326228-9x1233q6	242	22	defective	defective	JJ
cord-326228-9x1233q6	242	23	fission	fission	NN
cord-326228-9x1233q6	242	24	/	/	SYM
cord-326228-9x1233q6	242	25	fusion	fusion	NN
cord-326228-9x1233q6	242	26	dynamics	dynamic	NNS
cord-326228-9x1233q6	242	27	.	.	.
cord-326228-9x1233q6	243	1	OPA1	opa1	JJ
cord-326228-9x1233q6	243	2	guides	guide	NNS
cord-326228-9x1233q6	244	1	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	244	2	inner	inner	JJ
cord-326228-9x1233q6	244	3	membrane	membrane	NN
cord-326228-9x1233q6	244	4	fusion	fusion	NN
cord-326228-9x1233q6	244	5	,	,	,
cord-326228-9x1233q6	244	6	27	27	CD
cord-326228-9x1233q6	244	7	and	and	CC
cord-326228-9x1233q6	245	1	its	-PRON-	PRP$
cord-326228-9x1233q6	245	2	deficiency	deficiency	NN
cord-326228-9x1233q6	245	3	in	in	IN
cord-326228-9x1233q6	245	4	mice	mice	NN
cord-326228-9x1233q6	245	5	drives	drive	NNS
cord-326228-9x1233q6	245	6	increased	increase	VBD
cord-326228-9x1233q6	245	7	NLRP3	nlrp3	NN
cord-326228-9x1233q6	245	8	,	,	,
cord-326228-9x1233q6	245	9	ASC	ASC	NNP
cord-326228-9x1233q6	245	10	and	and	CC
cord-326228-9x1233q6	245	11	IL-1b	IL-1b	NNP
cord-326228-9x1233q6	245	12	expression	expression	NN
cord-326228-9x1233q6	245	13	and	and	CC
cord-326228-9x1233q6	246	1	increased	increase	VBN
cord-326228-9x1233q6	246	2	plasma	plasma	NN
cord-326228-9x1233q6	246	3	IL-1b	IL-1b	NNS
cord-326228-9x1233q6	246	4	.	.	.
cord-326228-9x1233q6	247	1	96	96	CD
cord-326228-9x1233q6	248	1	This	this	DT
cord-326228-9x1233q6	248	2	was	be	VBD
cord-326228-9x1233q6	248	3	cGASindependent	cGASindependent	NNP
cord-326228-9x1233q6	248	4	and	and	CC
cord-326228-9x1233q6	248	5	may	may	MD
cord-326228-9x1233q6	248	6	have	have	VB
cord-326228-9x1233q6	248	7	been	be	VBN
cord-326228-9x1233q6	248	8	TLRdependent	TLRdependent	VBN
cord-326228-9x1233q6	248	9	.	.	.
cord-326228-9x1233q6	249	1	96	96	CD
cord-326228-9x1233q6	249	2	Mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	249	3	in	in	IN
cord-326228-9x1233q6	249	4	OPA1	OPA1	NNP
cord-326228-9x1233q6	250	1	knockdown	knockdown	NN
cord-326228-9x1233q6	250	2	cells	cell	NNS
cord-326228-9x1233q6	250	3	appear	appear	VBP
cord-326228-9x1233q6	250	4	more	more	RBR
cord-326228-9x1233q6	250	5	fragmented	fragmented	JJ
cord-326228-9x1233q6	250	6	than	than	IN
cord-326228-9x1233q6	250	7	the	the	DT
cord-326228-9x1233q6	250	8	untreated	untreated	JJ
cord-326228-9x1233q6	250	9	cells	cell	NNS
cord-326228-9x1233q6	250	10	96	96	CD
cord-326228-9x1233q6	250	11	and	and	CC
cord-326228-9x1233q6	250	12	may	may	MD
cord-326228-9x1233q6	250	13	mimic	mimic	VB
cord-326228-9x1233q6	250	14	the	the	DT
cord-326228-9x1233q6	250	15	swing	swing	NN
cord-326228-9x1233q6	250	16	towards	towards	IN
cord-326228-9x1233q6	250	17	fission	fission	NN
cord-326228-9x1233q6	250	18	experienced	experience	VBN
cord-326228-9x1233q6	250	19	during	during	IN
cord-326228-9x1233q6	250	20	some	some	DT
cord-326228-9x1233q6	250	21	microbial	microbial	JJ
cord-326228-9x1233q6	250	22	infections	infection	NNS
cord-326228-9x1233q6	250	23	.	.	.
cord-326228-9x1233q6	251	1	Thus	thus	RB
cord-326228-9x1233q6	251	2	,	,	,
cord-326228-9x1233q6	251	3	some	some	DT
cord-326228-9x1233q6	251	4	forms	form	NNS
cord-326228-9x1233q6	251	5	of	of	IN
cord-326228-9x1233q6	251	6	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	251	7	disruption	disruption	NN
cord-326228-9x1233q6	251	8	may	may	MD
cord-326228-9x1233q6	251	9	deliver	deliver	VB
cord-326228-9x1233q6	251	10	a	a	DT
cord-326228-9x1233q6	251	11	TLR9-driven	TLR9-driven	NNP
cord-326228-9x1233q6	251	12	priming	priming	NN
cord-326228-9x1233q6	251	13	signal	signal	NN
cord-326228-9x1233q6	251	14	for	for	IN
cord-326228-9x1233q6	251	15	the	the	DT
cord-326228-9x1233q6	251	16	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	251	17	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	251	18	.	.	.
cord-326228-9x1233q6	252	1	Cytosolic	cytosolic	JJ
cord-326228-9x1233q6	252	2	DNA	dna	NN
cord-326228-9x1233q6	252	3	recognition	recognition	NN
cord-326228-9x1233q6	252	4	by	by	IN
cord-326228-9x1233q6	252	5	the	the	DT
cord-326228-9x1233q6	252	6	AIM2	AIM2	NNP
cord-326228-9x1233q6	252	7	inflammasome	inflammasome	NN
cord-326228-9x1233q6	252	8	Absent	Absent	NNP
cord-326228-9x1233q6	252	9	in	in	IN
cord-326228-9x1233q6	252	10	melanoma	melanoma	NN
cord-326228-9x1233q6	252	11	2	2	CD
cord-326228-9x1233q6	252	12	is	be	VBZ
cord-326228-9x1233q6	252	13	a	a	DT
cord-326228-9x1233q6	252	14	DNA	dna	NN
cord-326228-9x1233q6	252	15	sensor	sensor	NN
cord-326228-9x1233q6	252	16	that	that	WDT
cord-326228-9x1233q6	252	17	clusters	cluster	NNS
cord-326228-9x1233q6	252	18	on	on	IN
cord-326228-9x1233q6	252	19	cytoplasmic	cytoplasmic	JJ
cord-326228-9x1233q6	252	20	bacterial	bacterial	JJ
cord-326228-9x1233q6	252	21	,	,	,
cord-326228-9x1233q6	252	22	viral	viral	JJ
cord-326228-9x1233q6	252	23	or	or	CC
cord-326228-9x1233q6	252	24	host	host	NN
cord-326228-9x1233q6	252	25	dsDNA	dsdna	RB
cord-326228-9x1233q6	252	26	to	to	TO
cord-326228-9x1233q6	252	27	drive	drive	VB
cord-326228-9x1233q6	252	28	ASC	ASC	NNP
cord-326228-9x1233q6	252	29	-	-	HYPH
cord-326228-9x1233q6	252	30	dependent	dependent	JJ
cord-326228-9x1233q6	252	31	caspase-1	caspase-1	NNP
cord-326228-9x1233q6	252	32	activation	activation	NN
cord-326228-9x1233q6	252	33	,	,	,
cord-326228-9x1233q6	252	34	IL-1b	IL-1b	NNP
cord-326228-9x1233q6	252	35	and	and	CC
cord-326228-9x1233q6	252	36	IL-18	IL-18	NNP
cord-326228-9x1233q6	252	37	maturation	maturation	NN
cord-326228-9x1233q6	252	38	and	and	CC
cord-326228-9x1233q6	252	39	pyroptosis	pyroptosis	NN
cord-326228-9x1233q6	252	40	.	.	.
cord-326228-9x1233q6	253	1	102	102	CD
cord-326228-9x1233q6	253	2	,	,	,
cord-326228-9x1233q6	253	3	103	103	CD
cord-326228-9x1233q6	253	4	mtDNA	mtdna	NN
cord-326228-9x1233q6	253	5	is	be	VBZ
cord-326228-9x1233q6	253	6	approximately	approximately	RB
cord-326228-9x1233q6	253	7	17	17	CD
cord-326228-9x1233q6	253	8	kb	kb	NNS
cord-326228-9x1233q6	253	9	in	in	IN
cord-326228-9x1233q6	253	10	size	size	NN
cord-326228-9x1233q6	253	11	,	,	,
cord-326228-9x1233q6	253	12	104	104	CD
cord-326228-9x1233q6	253	13	and	and	CC
cord-326228-9x1233q6	253	14	AIM2	AIM2	NNP
cord-326228-9x1233q6	253	15	clusters	cluster	NNS
cord-326228-9x1233q6	253	16	upon	upon	IN
cord-326228-9x1233q6	253	17	DNA	dna	NN
cord-326228-9x1233q6	253	18	fragments	fragment	NNS
cord-326228-9x1233q6	253	19	≥	≥	CD
cord-326228-9x1233q6	253	20	180bp	180bp	NNP
cord-326228-9x1233q6	253	21	105	105	CD
cord-326228-9x1233q6	253	22	;	;	:
cord-326228-9x1233q6	253	23	as	as	IN
cord-326228-9x1233q6	253	24	such	such	JJ
cord-326228-9x1233q6	253	25	,	,	,
cord-326228-9x1233q6	253	26	cytoplasmic	cytoplasmic	JJ
cord-326228-9x1233q6	253	27	mtDNA	mtdna	NN
cord-326228-9x1233q6	253	28	meets	meet	VBZ
cord-326228-9x1233q6	253	29	AIM2	AIM2	NNP
cord-326228-9x1233q6	253	30	ligand	ligand	NN
cord-326228-9x1233q6	253	31	requirements	requirement	NNS
cord-326228-9x1233q6	253	32	.	.	.
cord-326228-9x1233q6	254	1	While	while	IN
cord-326228-9x1233q6	254	2	the	the	DT
cord-326228-9x1233q6	254	3	available	available	JJ
cord-326228-9x1233q6	254	4	evidence	evidence	NN
cord-326228-9x1233q6	254	5	is	be	VBZ
cord-326228-9x1233q6	254	6	limited	limit	VBN
cord-326228-9x1233q6	254	7	,	,	,
cord-326228-9x1233q6	254	8	it	-PRON-	PRP
cord-326228-9x1233q6	254	9	supports	support	VBZ
cord-326228-9x1233q6	254	10	the	the	DT
cord-326228-9x1233q6	254	11	hypothesis	hypothesis	NN
cord-326228-9x1233q6	254	12	that	that	IN
cord-326228-9x1233q6	254	13	cytoplasmic	cytoplasmic	JJ
cord-326228-9x1233q6	254	14	mtDNA	mtdna	NN
cord-326228-9x1233q6	254	15	triggers	trigger	VBZ
cord-326228-9x1233q6	254	16	AIM2	AIM2	NNP
cord-326228-9x1233q6	254	17	inflammasome	inflammasome	NN
cord-326228-9x1233q6	254	18	signalling	signal	VBG
cord-326228-9x1233q6	254	19	.	.	.
cord-326228-9x1233q6	255	1	Transfected	transfected	JJ
cord-326228-9x1233q6	255	2	mtDNA	mtdna	NN
cord-326228-9x1233q6	255	3	induced	induce	VBD
cord-326228-9x1233q6	255	4	AIM2dependent	AIM2dependent	NNP
cord-326228-9x1233q6	255	5	IL-1b	IL-1b	NNP
cord-326228-9x1233q6	255	6	secretion	secretion	NN
cord-326228-9x1233q6	255	7	in	in	IN
cord-326228-9x1233q6	255	8	BMDMs	bmdms	NN
cord-326228-9x1233q6	255	9	,	,	,
cord-326228-9x1233q6	255	10	and	and	CC
cord-326228-9x1233q6	255	11	transfected	transfecte	VBN
cord-326228-9x1233q6	255	12	mtDNA	mtdna	NN
cord-326228-9x1233q6	255	13	bound	bind	VBN
cord-326228-9x1233q6	255	14	to	to	IN
cord-326228-9x1233q6	255	15	ectopically	ectopically	RB
cord-326228-9x1233q6	255	16	expressed	express	VBN
cord-326228-9x1233q6	255	17	AIM2	AIM2	NNP
cord-326228-9x1233q6	255	18	in	in	IN
cord-326228-9x1233q6	255	19	HEK293	HEK293	NNP
cord-326228-9x1233q6	255	20	cells	cell	NNS
cord-326228-9x1233q6	255	21	.	.	.
cord-326228-9x1233q6	256	1	14	14	CD
cord-326228-9x1233q6	257	1	In	in	IN
cord-326228-9x1233q6	257	2	addition	addition	NN
cord-326228-9x1233q6	257	3	,	,	,
cord-326228-9x1233q6	257	4	circulating	circulate	VBG
cord-326228-9x1233q6	257	5	cell	cell	NN
cord-326228-9x1233q6	257	6	-	-	HYPH
cord-326228-9x1233q6	257	7	free	free	JJ
cord-326228-9x1233q6	257	8	mtDNA	mtdna	NN
cord-326228-9x1233q6	257	9	(	(	-LRB-
cord-326228-9x1233q6	257	10	ccf	ccf	NN
cord-326228-9x1233q6	257	11	-	-	HYPH
cord-326228-9x1233q6	257	12	mtDNA	mtdna	JJ
cord-326228-9x1233q6	257	13	)	)	-RRB-
cord-326228-9x1233q6	257	14	from	from	IN
cord-326228-9x1233q6	257	15	type	type	NN
cord-326228-9x1233q6	257	16	2	2	CD
cord-326228-9x1233q6	257	17	diabetic	diabetic	JJ
cord-326228-9x1233q6	257	18	patients	patient	NNS
cord-326228-9x1233q6	257	19	triggered	trigger	VBD
cord-326228-9x1233q6	257	20	AIM2	AIM2	NNP
cord-326228-9x1233q6	257	21	signalling	signal	VBG
cord-326228-9x1233q6	257	22	in	in	IN
cord-326228-9x1233q6	257	23	mouse	mouse	NN
cord-326228-9x1233q6	257	24	BMDMs	bmdm	NNS
cord-326228-9x1233q6	257	25	.	.	.
cord-326228-9x1233q6	258	1	106	106	CD
cord-326228-9x1233q6	259	1	Thus	thus	RB
cord-326228-9x1233q6	259	2	,	,	,
cord-326228-9x1233q6	259	3	while	while	IN
cord-326228-9x1233q6	259	4	the	the	DT
cord-326228-9x1233q6	259	5	field	field	NN
cord-326228-9x1233q6	259	6	awaits	await	VBZ
cord-326228-9x1233q6	259	7	formal	formal	JJ
cord-326228-9x1233q6	259	8	confirmation	confirmation	NN
cord-326228-9x1233q6	259	9	that	that	IN
cord-326228-9x1233q6	259	10	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	259	11	is	be	VBZ
cord-326228-9x1233q6	259	12	a	a	DT
cord-326228-9x1233q6	259	13	bona	bona	JJ
cord-326228-9x1233q6	259	14	fide	fide	JJ
cord-326228-9x1233q6	259	15	ligand	ligand	NN
cord-326228-9x1233q6	259	16	for	for	IN
cord-326228-9x1233q6	259	17	human	human	JJ
cord-326228-9x1233q6	259	18	AIM2	AIM2	NNP
cord-326228-9x1233q6	259	19	,	,	,
cord-326228-9x1233q6	259	20	this	this	DT
cord-326228-9x1233q6	259	21	seems	seem	VBZ
cord-326228-9x1233q6	259	22	likely	likely	JJ
cord-326228-9x1233q6	259	23	.	.	.
cord-326228-9x1233q6	260	1	Nod	nod	JJ
cord-326228-9x1233q6	260	2	-	-	HYPH
cord-326228-9x1233q6	260	3	like	like	JJ
cord-326228-9x1233q6	260	4	receptor	receptor	NN
cord-326228-9x1233q6	260	5	protein	protein	NN
cord-326228-9x1233q6	260	6	3	3	CD
cord-326228-9x1233q6	260	7	drives	drive	VBZ
cord-326228-9x1233q6	260	8	a	a	DT
cord-326228-9x1233q6	260	9	wide	wide	JJ
cord-326228-9x1233q6	260	10	range	range	NN
cord-326228-9x1233q6	260	11	of	of	IN
cord-326228-9x1233q6	260	12	acquired	acquire	VBN
cord-326228-9x1233q6	260	13	and	and	CC
cord-326228-9x1233q6	260	14	hereditary	hereditary	JJ
cord-326228-9x1233q6	260	15	autoinflammatory	autoinflammatory	JJ
cord-326228-9x1233q6	260	16	diseases	disease	NNS
cord-326228-9x1233q6	260	17	.	.	.
cord-326228-9x1233q6	261	1	As	as	IN
cord-326228-9x1233q6	261	2	such	such	JJ
cord-326228-9x1233q6	261	3	,	,	,
cord-326228-9x1233q6	261	4	investigations	investigation	NNS
cord-326228-9x1233q6	261	5	into	into	IN
cord-326228-9x1233q6	261	6	NLRP3	nlrp3	NN
cord-326228-9x1233q6	261	7	activation	activation	NN
cord-326228-9x1233q6	261	8	mechanisms	mechanism	NNS
cord-326228-9x1233q6	261	9	have	have	VBP
cord-326228-9x1233q6	261	10	the	the	DT
cord-326228-9x1233q6	261	11	potential	potential	NN
cord-326228-9x1233q6	261	12	to	to	TO
cord-326228-9x1233q6	261	13	reveal	reveal	VB
cord-326228-9x1233q6	261	14	novel	novel	JJ
cord-326228-9x1233q6	261	15	anti	anti	JJ
cord-326228-9x1233q6	261	16	-	-	JJ
cord-326228-9x1233q6	261	17	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	261	18	strategies	strategy	NNS
cord-326228-9x1233q6	261	19	.	.	.
cord-326228-9x1233q6	262	1	Cytosolic	cytosolic	JJ
cord-326228-9x1233q6	262	2	sensors	sensor	NNS
cord-326228-9x1233q6	262	3	for	for	IN
cord-326228-9x1233q6	262	4	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	262	5	alert	alert	VB
cord-326228-9x1233q6	262	6	the	the	DT
cord-326228-9x1233q6	262	7	cell	cell	NN
cord-326228-9x1233q6	262	8	to	to	IN
cord-326228-9x1233q6	262	9	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	262	10	permeabilisation	permeabilisation	NN
cord-326228-9x1233q6	262	11	,	,	,
cord-326228-9x1233q6	262	12	a	a	DT
cord-326228-9x1233q6	262	13	potentially	potentially	RB
cord-326228-9x1233q6	262	14	catastrophic	catastrophic	JJ
cord-326228-9x1233q6	262	15	event	event	NN
cord-326228-9x1233q6	262	16	induced	induce	VBN
cord-326228-9x1233q6	262	17	by	by	IN
cord-326228-9x1233q6	262	18	severe	severe	JJ
cord-326228-9x1233q6	262	19	cell	cell	NN
cord-326228-9x1233q6	262	20	damage	damage	NN
cord-326228-9x1233q6	262	21	.	.	.
cord-326228-9x1233q6	263	1	While	while	IN
cord-326228-9x1233q6	263	2	this	this	DT
cord-326228-9x1233q6	263	3	damage	damage	NN
cord-326228-9x1233q6	263	4	is	be	VBZ
cord-326228-9x1233q6	263	5	self	self	NN
cord-326228-9x1233q6	263	6	-	-	HYPH
cord-326228-9x1233q6	263	7	limiting	limit	VBG
cord-326228-9x1233q6	263	8	in	in	IN
cord-326228-9x1233q6	263	9	healthy	healthy	JJ
cord-326228-9x1233q6	263	10	individuals	individual	NNS
cord-326228-9x1233q6	263	11	,	,	,
cord-326228-9x1233q6	263	12	it	-PRON-	PRP
cord-326228-9x1233q6	263	13	is	be	VBZ
cord-326228-9x1233q6	263	14	possible	possible	JJ
cord-326228-9x1233q6	263	15	that	that	IN
cord-326228-9x1233q6	263	16	genetic	genetic	JJ
cord-326228-9x1233q6	263	17	or	or	CC
cord-326228-9x1233q6	263	18	environmental	environmental	JJ
cord-326228-9x1233q6	263	19	factors	factor	NNS
cord-326228-9x1233q6	263	20	that	that	WDT
cord-326228-9x1233q6	263	21	prolong	prolong	VBP
cord-326228-9x1233q6	263	22	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	263	23	disruption	disruption	NN
cord-326228-9x1233q6	263	24	drive	drive	VBP
cord-326228-9x1233q6	263	25	chronic	chronic	JJ
cord-326228-9x1233q6	263	26	NLRP3	nlrp3	NN
cord-326228-9x1233q6	263	27	activation	activation	NN
cord-326228-9x1233q6	263	28	and	and	CC
cord-326228-9x1233q6	263	29	contribute	contribute	VB
cord-326228-9x1233q6	263	30	to	to	IN
cord-326228-9x1233q6	263	31	disease	disease	NN
cord-326228-9x1233q6	263	32	pathology	pathology	NN
cord-326228-9x1233q6	263	33	.	.	.
cord-326228-9x1233q6	264	1	ccf	ccf	NNP
cord-326228-9x1233q6	264	2	-	-	HYPH
cord-326228-9x1233q6	264	3	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	264	4	is	be	VBZ
cord-326228-9x1233q6	264	5	upregulated	upregulate	VBN
cord-326228-9x1233q6	264	6	in	in	IN
cord-326228-9x1233q6	264	7	patients	patient	NNS
cord-326228-9x1233q6	264	8	with	with	IN
cord-326228-9x1233q6	264	9	NLRP3-driven	NLRP3-driven	NNP
cord-326228-9x1233q6	264	10	inflammation	inflammation	NN
cord-326228-9x1233q6	264	11	,	,	,
cord-326228-9x1233q6	264	12	and	and	CC
cord-326228-9x1233q6	264	13	may	may	MD
cord-326228-9x1233q6	264	14	contribute	contribute	VB
cord-326228-9x1233q6	264	15	to	to	IN
cord-326228-9x1233q6	264	16	disease	disease	NN
cord-326228-9x1233q6	264	17	severity	severity	NN
cord-326228-9x1233q6	264	18	in	in	IN
cord-326228-9x1233q6	264	19	conditions	condition	NNS
cord-326228-9x1233q6	264	20	such	such	JJ
cord-326228-9x1233q6	264	21	as	as	IN
cord-326228-9x1233q6	264	22	cardiovascular	cardiovascular	JJ
cord-326228-9x1233q6	264	23	disease	disease	NN
cord-326228-9x1233q6	264	24	107	107	CD
cord-326228-9x1233q6	264	25	and	and	CC
cord-326228-9x1233q6	264	26	chronic	chronic	JJ
cord-326228-9x1233q6	264	27	low	low	JJ
cord-326228-9x1233q6	264	28	-	-	HYPH
cord-326228-9x1233q6	264	29	level	level	NN
cord-326228-9x1233q6	264	30	age	age	NN
cord-326228-9x1233q6	264	31	-	-	HYPH
cord-326228-9x1233q6	264	32	related	relate	VBN
cord-326228-9x1233q6	264	33	inflammation	inflammation	NN
cord-326228-9x1233q6	264	34	(	(	-LRB-
cord-326228-9x1233q6	264	35	inflammaging	inflammage	VBG
cord-326228-9x1233q6	264	36	)	)	-RRB-
cord-326228-9x1233q6	264	37	.	.	.
cord-326228-9x1233q6	265	1	108	108	CD
cord-326228-9x1233q6	266	1	In	in	IN
cord-326228-9x1233q6	266	2	murine	murine	JJ
cord-326228-9x1233q6	266	3	models	model	NNS
cord-326228-9x1233q6	266	4	,	,	,
cord-326228-9x1233q6	266	5	ccf	ccf	NN
cord-326228-9x1233q6	266	6	-	-	HYPH
cord-326228-9x1233q6	266	7	mtDNA	mtdna	JJ
cord-326228-9x1233q6	266	8	predisposes	predispose	VBZ
cord-326228-9x1233q6	266	9	mice	mouse	NNS
cord-326228-9x1233q6	266	10	to	to	TO
cord-326228-9x1233q6	266	11	type	type	VB
cord-326228-9x1233q6	266	12	I	-PRON-	PRP
cord-326228-9x1233q6	266	13	diabetes	diabete	VBZ
cord-326228-9x1233q6	266	14	.	.	.
cord-326228-9x1233q6	267	1	109	109	CD
cord-326228-9x1233q6	267	2	Patients	patient	NNS
cord-326228-9x1233q6	267	3	with	with	IN
cord-326228-9x1233q6	267	4	type	type	NN
cord-326228-9x1233q6	267	5	II	ii	CD
cord-326228-9x1233q6	267	6	diabetes	diabetes	NN
cord-326228-9x1233q6	267	7	and	and	CC
cord-326228-9x1233q6	267	8	coronary	coronary	JJ
cord-326228-9x1233q6	267	9	heart	heart	NN
cord-326228-9x1233q6	267	10	disease	disease	NN
cord-326228-9x1233q6	267	11	exhibit	exhibit	NN
cord-326228-9x1233q6	267	12	significantly	significantly	RB
cord-326228-9x1233q6	267	13	elevated	elevate	VBN
cord-326228-9x1233q6	267	14	levels	level	NNS
cord-326228-9x1233q6	267	15	of	of	IN
cord-326228-9x1233q6	267	16	ccf	ccf	NN
cord-326228-9x1233q6	267	17	-	-	HYPH
cord-326228-9x1233q6	267	18	mtDNA	mtdna	NN
cord-326228-9x1233q6	267	19	compared	compare	VBN
cord-326228-9x1233q6	267	20	to	to	IN
cord-326228-9x1233q6	267	21	their	-PRON-	PRP$
cord-326228-9x1233q6	267	22	healthy	healthy	JJ
cord-326228-9x1233q6	267	23	counterparts	counterpart	NNS
cord-326228-9x1233q6	267	24	.	.	.
cord-326228-9x1233q6	268	1	110	110	CD
cord-326228-9x1233q6	269	1	In	in	IN
cord-326228-9x1233q6	269	2	chronic	chronic	JJ
cord-326228-9x1233q6	269	3	obstructive	obstructive	JJ
cord-326228-9x1233q6	269	4	pulmonary	pulmonary	JJ
cord-326228-9x1233q6	269	5	disease	disease	NN
cord-326228-9x1233q6	269	6	(	(	-LRB-
cord-326228-9x1233q6	269	7	COPD	COPD	NNP
cord-326228-9x1233q6	269	8	)	)	-RRB-
cord-326228-9x1233q6	269	9	,	,	,
cord-326228-9x1233q6	269	10	ccf	ccf	NN
cord-326228-9x1233q6	269	11	-	-	HYPH
cord-326228-9x1233q6	269	12	mtDNA	mtdna	NN
cord-326228-9x1233q6	269	13	may	may	MD
cord-326228-9x1233q6	269	14	activate	activate	VB
cord-326228-9x1233q6	269	15	TLR9	TLR9	NNP
cord-326228-9x1233q6	269	16	to	to	TO
cord-326228-9x1233q6	269	17	drive	drive	VB
cord-326228-9x1233q6	269	18	inflammation	inflammation	NN
cord-326228-9x1233q6	269	19	111	111	CD
cord-326228-9x1233q6	269	20	and	and	CC
cord-326228-9x1233q6	269	21	may	may	MD
cord-326228-9x1233q6	269	22	potentially	potentially	RB
cord-326228-9x1233q6	269	23	provide	provide	VB
cord-326228-9x1233q6	269	24	signal	signal	NN
cord-326228-9x1233q6	269	25	1	1	CD
cord-326228-9x1233q6	269	26	for	for	IN
cord-326228-9x1233q6	269	27	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	269	28	activation	activation	NN
cord-326228-9x1233q6	269	29	,	,	,
cord-326228-9x1233q6	269	30	as	as	IN
cord-326228-9x1233q6	269	31	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	269	32	contributes	contribute	VBZ
cord-326228-9x1233q6	269	33	to	to	IN
cord-326228-9x1233q6	269	34	disease	disease	NN
cord-326228-9x1233q6	269	35	pathology	pathology	NN
cord-326228-9x1233q6	269	36	.	.	.
cord-326228-9x1233q6	270	1	112	112	CD
cord-326228-9x1233q6	271	1	Parkinson	Parkinson	NNP
cord-326228-9x1233q6	271	2	's	's	POS
cord-326228-9x1233q6	271	3	disease	disease	NN
cord-326228-9x1233q6	271	4	(	(	-LRB-
cord-326228-9x1233q6	271	5	PD	PD	NNP
cord-326228-9x1233q6	271	6	)	)	-RRB-
cord-326228-9x1233q6	271	7	is	be	VBZ
cord-326228-9x1233q6	271	8	a	a	DT
cord-326228-9x1233q6	271	9	neurodegenerative	neurodegenerative	JJ
cord-326228-9x1233q6	271	10	disorder	disorder	NN
cord-326228-9x1233q6	271	11	that	that	WDT
cord-326228-9x1233q6	271	12	is	be	VBZ
cord-326228-9x1233q6	271	13	strongly	strongly	RB
cord-326228-9x1233q6	271	14	linked	link	VBN
cord-326228-9x1233q6	271	15	to	to	IN
cord-326228-9x1233q6	271	16	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	271	17	dysfunction	dysfunction	NN
cord-326228-9x1233q6	271	18	and	and	CC
cord-326228-9x1233q6	271	19	NLRP3-driven	NLRP3-driven	NNP
cord-326228-9x1233q6	271	20	pathology	pathology	NN
cord-326228-9x1233q6	271	21	.	.	.
cord-326228-9x1233q6	272	1	PD	PD	NNP
cord-326228-9x1233q6	272	2	is	be	VBZ
cord-326228-9x1233q6	272	3	causally	causally	RB
cord-326228-9x1233q6	272	4	associated	associate	VBN
cord-326228-9x1233q6	272	5	with	with	IN
cord-326228-9x1233q6	272	6	mutations	mutation	NNS
cord-326228-9x1233q6	272	7	in	in	IN
cord-326228-9x1233q6	272	8	genes	gene	NNS
cord-326228-9x1233q6	272	9	involved	involve	VBN
cord-326228-9x1233q6	272	10	in	in	IN
cord-326228-9x1233q6	272	11	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	272	12	functions	function	NNS
cord-326228-9x1233q6	272	13	(	(	-LRB-
cord-326228-9x1233q6	272	14	e.g.	e.g.	IN
cord-326228-9x1233q6	272	15	OXPHOS	OXPHOS	NNP
cord-326228-9x1233q6	272	16	)	)	-RRB-
cord-326228-9x1233q6	272	17	or	or	CC
cord-326228-9x1233q6	272	18	maintenance	maintenance	NN
cord-326228-9x1233q6	272	19	(	(	-LRB-
cord-326228-9x1233q6	272	20	e.g.	e.g.	IN
cord-326228-9x1233q6	272	21	mitophagy	mitophagy	NNP
cord-326228-9x1233q6	272	22	)	)	-RRB-
cord-326228-9x1233q6	272	23	.	.	.
cord-326228-9x1233q6	273	1	113	113	CD
cord-326228-9x1233q6	274	1	The	the	DT
cord-326228-9x1233q6	274	2	NLRP3	nlrp3	NN
cord-326228-9x1233q6	274	3	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	274	4	induces	induce	VBZ
cord-326228-9x1233q6	274	5	neuroinflammation	neuroinflammation	NN
cord-326228-9x1233q6	274	6	and	and	CC
cord-326228-9x1233q6	274	7	drives	drive	VBZ
cord-326228-9x1233q6	274	8	PD	PD	NNP
cord-326228-9x1233q6	274	9	pathogenesis	pathogenesis	NN
cord-326228-9x1233q6	274	10	,	,	,
cord-326228-9x1233q6	274	11	as	as	IN
cord-326228-9x1233q6	274	12	murine	murine	JJ
cord-326228-9x1233q6	274	13	models	model	NNS
cord-326228-9x1233q6	274	14	of	of	IN
cord-326228-9x1233q6	274	15	PD	PD	NNP
cord-326228-9x1233q6	274	16	are	be	VBP
cord-326228-9x1233q6	274	17	protected	protect	VBN
cord-326228-9x1233q6	274	18	from	from	IN
cord-326228-9x1233q6	274	19	disease	disease	NN
cord-326228-9x1233q6	274	20	by	by	IN
cord-326228-9x1233q6	274	21	Nlrp3	Nlrp3	NNP
cord-326228-9x1233q6	274	22	deficiency	deficiency	NN
cord-326228-9x1233q6	274	23	or	or	CC
cord-326228-9x1233q6	274	24	dosing	dose	VBG
cord-326228-9x1233q6	274	25	with	with	IN
cord-326228-9x1233q6	274	26	MCC950	MCC950	NNP
cord-326228-9x1233q6	274	27	,	,	,
cord-326228-9x1233q6	274	28	38	38	CD
cord-326228-9x1233q6	274	29	a	a	DT
cord-326228-9x1233q6	274	30	small	small	JJ
cord-326228-9x1233q6	274	31	-	-	HYPH
cord-326228-9x1233q6	274	32	molecule	molecule	NN
cord-326228-9x1233q6	274	33	NLRP3	nlrp3	NN
cord-326228-9x1233q6	274	34	inhibitor	inhibitor	NN
cord-326228-9x1233q6	274	35	.	.	.
cord-326228-9x1233q6	275	1	114	114	CD
cord-326228-9x1233q6	275	2	,	,	,
cord-326228-9x1233q6	275	3	115	115	CD
cord-326228-9x1233q6	276	1	Excitingly	excitingly	RB
cord-326228-9x1233q6	276	2	,	,	,
cord-326228-9x1233q6	276	3	MCC950	MCC950	NNP
cord-326228-9x1233q6	276	4	suppressed	suppress	VBD
cord-326228-9x1233q6	276	5	disease	disease	NN
cord-326228-9x1233q6	276	6	in	in	IN
cord-326228-9x1233q6	276	7	a	a	DT
cord-326228-9x1233q6	276	8	murine	murine	JJ
cord-326228-9x1233q6	276	9	model	model	NN
cord-326228-9x1233q6	276	10	of	of	IN
cord-326228-9x1233q6	276	11	PD	PD	NNP
cord-326228-9x1233q6	276	12	in	in	IN
cord-326228-9x1233q6	276	13	which	which	WDT
cord-326228-9x1233q6	276	14	dopaminergic	dopaminergic	JJ
cord-326228-9x1233q6	276	15	neurons	neuron	NNS
cord-326228-9x1233q6	276	16	are	be	VBP
cord-326228-9x1233q6	276	17	deficient	deficient	JJ
cord-326228-9x1233q6	276	18	in	in	IN
cord-326228-9x1233q6	276	19	TFAM	TFAM	NNP
cord-326228-9x1233q6	276	20	(	(	-LRB-
cord-326228-9x1233q6	276	21	MitoPark	MitoPark	NNP
cord-326228-9x1233q6	276	22	model	model	NN
cord-326228-9x1233q6	276	23	)	)	-RRB-
cord-326228-9x1233q6	276	24	.	.	.
cord-326228-9x1233q6	277	1	38	38	CD
cord-326228-9x1233q6	278	1	This	this	DT
cord-326228-9x1233q6	278	2	highlights	highlight	VBZ
cord-326228-9x1233q6	278	3	NLRP3	nlrp3	XX
cord-326228-9x1233q6	278	4	inhibition	inhibition	NN
cord-326228-9x1233q6	278	5	as	as	IN
cord-326228-9x1233q6	278	6	a	a	DT
cord-326228-9x1233q6	278	7	promising	promising	JJ
cord-326228-9x1233q6	278	8	therapeutic	therapeutic	JJ
cord-326228-9x1233q6	278	9	strategy	strategy	NN
cord-326228-9x1233q6	278	10	for	for	IN
cord-326228-9x1233q6	278	11	the	the	DT
cord-326228-9x1233q6	278	12	treatment	treatment	NN
cord-326228-9x1233q6	278	13	of	of	IN
cord-326228-9x1233q6	278	14	PD	PD	NNP
cord-326228-9x1233q6	278	15	and	and	CC
cord-326228-9x1233q6	278	16	other	other	JJ
cord-326228-9x1233q6	278	17	diseases	disease	NNS
cord-326228-9x1233q6	278	18	involving	involve	VBG
cord-326228-9x1233q6	278	19	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	278	20	dysfunction	dysfunction	NN
cord-326228-9x1233q6	278	21	.	.	.
cord-326228-9x1233q6	279	1	To	to	TO
cord-326228-9x1233q6	279	2	determine	determine	VB
cord-326228-9x1233q6	279	3	how	how	WRB
cord-326228-9x1233q6	279	4	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	279	5	may	may	MD
cord-326228-9x1233q6	279	6	drive	drive	VB
cord-326228-9x1233q6	279	7	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	279	8	and	and	CC
cord-326228-9x1233q6	279	9	neurodegenerative	neurodegenerative	JJ
cord-326228-9x1233q6	279	10	diseases	disease	NNS
cord-326228-9x1233q6	279	11	,	,	,
cord-326228-9x1233q6	279	12	it	-PRON-	PRP
cord-326228-9x1233q6	279	13	is	be	VBZ
cord-326228-9x1233q6	279	14	important	important	JJ
cord-326228-9x1233q6	279	15	to	to	TO
cord-326228-9x1233q6	279	16	understand	understand	VB
cord-326228-9x1233q6	279	17	how	how	WRB
cord-326228-9x1233q6	279	18	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	279	19	participate	participate	VBP
cord-326228-9x1233q6	279	20	in	in	IN
cord-326228-9x1233q6	279	21	normal	normal	JJ
cord-326228-9x1233q6	279	22	immune	immune	JJ
cord-326228-9x1233q6	279	23	signalling	signalling	NN
cord-326228-9x1233q6	279	24	.	.	.
cord-326228-9x1233q6	280	1	Sterile	sterile	JJ
cord-326228-9x1233q6	280	2	(	(	-LRB-
cord-326228-9x1233q6	280	3	host	host	NN
cord-326228-9x1233q6	280	4	-	-	HYPH
cord-326228-9x1233q6	280	5	derived	derive	VBN
cord-326228-9x1233q6	280	6	)	)	-RRB-
cord-326228-9x1233q6	280	7	signals	signal	NNS
cord-326228-9x1233q6	280	8	are	be	VBP
cord-326228-9x1233q6	280	9	generally	generally	RB
cord-326228-9x1233q6	280	10	less	less	RBR
cord-326228-9x1233q6	280	11	potent	potent	JJ
cord-326228-9x1233q6	280	12	than	than	IN
cord-326228-9x1233q6	280	13	pathogen	pathogen	NN
cord-326228-9x1233q6	280	14	-	-	HYPH
cord-326228-9x1233q6	280	15	derived	derive	VBN
cord-326228-9x1233q6	280	16	signals	signal	NNS
cord-326228-9x1233q6	280	17	such	such	JJ
cord-326228-9x1233q6	280	18	as	as	IN
cord-326228-9x1233q6	280	19	signals	signal	NNS
cord-326228-9x1233q6	280	20	1	1	CD
cord-326228-9x1233q6	280	21	and	and	CC
cord-326228-9x1233q6	280	22	2	2	CD
cord-326228-9x1233q6	280	23	for	for	IN
cord-326228-9x1233q6	280	24	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	280	25	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	280	26	activation	activation	NN
cord-326228-9x1233q6	280	27	.	.	.
cord-326228-9x1233q6	281	1	116	116	CD
cord-326228-9x1233q6	282	1	This	this	DT
cord-326228-9x1233q6	282	2	is	be	VBZ
cord-326228-9x1233q6	282	3	desirable	desirable	JJ
cord-326228-9x1233q6	282	4	,	,	,
cord-326228-9x1233q6	282	5	as	as	IN
cord-326228-9x1233q6	282	6	immunogenic	immunogenic	JJ
cord-326228-9x1233q6	282	7	host	host	NN
cord-326228-9x1233q6	282	8	molecules	molecule	NNS
cord-326228-9x1233q6	282	9	could	could	MD
cord-326228-9x1233q6	282	10	trigger	trigger	VB
cord-326228-9x1233q6	282	11	rampant	rampant	JJ
cord-326228-9x1233q6	282	12	,	,	,
cord-326228-9x1233q6	282	13	unintended	unintended	JJ
cord-326228-9x1233q6	282	14	inflammation	inflammation	NN
cord-326228-9x1233q6	282	15	.	.	.
cord-326228-9x1233q6	283	1	As	as	IN
cord-326228-9x1233q6	283	2	bacteria	bacteria	NNS
cord-326228-9x1233q6	283	3	-	-	HYPH
cord-326228-9x1233q6	283	4	like	like	JJ
cord-326228-9x1233q6	283	5	organelles	organelle	NNS
cord-326228-9x1233q6	283	6	,	,	,
cord-326228-9x1233q6	283	7	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	283	8	provide	provide	VBP
cord-326228-9x1233q6	283	9	a	a	DT
cord-326228-9x1233q6	283	10	potent	potent	JJ
cord-326228-9x1233q6	283	11	'	'	''
cord-326228-9x1233q6	283	12	in	in	IN
cord-326228-9x1233q6	283	13	-	-	HYPH
cord-326228-9x1233q6	283	14	house	house	NN
cord-326228-9x1233q6	283	15	'	'	''
cord-326228-9x1233q6	283	16	pseudo	pseudo	JJ
cord-326228-9x1233q6	283	17	-	-	JJ
cord-326228-9x1233q6	283	18	pathogen	pathogen	NN
cord-326228-9x1233q6	283	19	signal	signal	NN
cord-326228-9x1233q6	283	20	that	that	WDT
cord-326228-9x1233q6	283	21	can	can	MD
cord-326228-9x1233q6	283	22	boost	boost	VB
cord-326228-9x1233q6	283	23	the	the	DT
cord-326228-9x1233q6	283	24	innate	innate	JJ
cord-326228-9x1233q6	283	25	response	response	NN
cord-326228-9x1233q6	283	26	to	to	IN
cord-326228-9x1233q6	283	27	immune	immune	JJ
cord-326228-9x1233q6	283	28	-	-	HYPH
cord-326228-9x1233q6	283	29	evasive	evasive	JJ
cord-326228-9x1233q6	283	30	pathogens	pathogen	NNS
cord-326228-9x1233q6	283	31	.	.	.
cord-326228-9x1233q6	284	1	Normally	normally	RB
cord-326228-9x1233q6	284	2	,	,	,
cord-326228-9x1233q6	284	3	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	284	4	immunogenic	immunogenic	JJ
cord-326228-9x1233q6	284	5	components	component	NNS
cord-326228-9x1233q6	284	6	are	be	VBP
cord-326228-9x1233q6	284	7	shielded	shield	VBN
cord-326228-9x1233q6	284	8	from	from	IN
cord-326228-9x1233q6	284	9	cytosolic	cytosolic	JJ
cord-326228-9x1233q6	284	10	and	and	CC
cord-326228-9x1233q6	284	11	endosomal	endosomal	NNP
cord-326228-9x1233q6	284	12	PRRs	prr	NNS
cord-326228-9x1233q6	284	13	by	by	IN
cord-326228-9x1233q6	284	14	the	the	DT
cord-326228-9x1233q6	284	15	dual	dual	JJ
cord-326228-9x1233q6	284	16	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	284	17	membranes	membrane	NNS
cord-326228-9x1233q6	284	18	.	.	.
cord-326228-9x1233q6	285	1	Mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	285	2	permeabilisation	permeabilisation	NN
cord-326228-9x1233q6	285	3	,	,	,
cord-326228-9x1233q6	285	4	indicating	indicate	VBG
cord-326228-9x1233q6	285	5	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	285	6	damage	damage	NN
cord-326228-9x1233q6	285	7	,	,	,
cord-326228-9x1233q6	285	8	allows	allow	VBZ
cord-326228-9x1233q6	285	9	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	285	10	components	component	NNS
cord-326228-9x1233q6	285	11	to	to	TO
cord-326228-9x1233q6	285	12	be	be	VB
cord-326228-9x1233q6	285	13	liberated	liberate	VBN
cord-326228-9x1233q6	285	14	for	for	IN
cord-326228-9x1233q6	285	15	immune	immune	JJ
cord-326228-9x1233q6	285	16	recognition	recognition	NN
cord-326228-9x1233q6	285	17	,	,	,
cord-326228-9x1233q6	285	18	thereby	thereby	RB
cord-326228-9x1233q6	285	19	providing	provide	VBG
cord-326228-9x1233q6	285	20	a	a	DT
cord-326228-9x1233q6	285	21	strong	strong	JJ
cord-326228-9x1233q6	285	22	cellular	cellular	JJ
cord-326228-9x1233q6	285	23	distress	distress	NN
cord-326228-9x1233q6	285	24	signal	signal	NN
cord-326228-9x1233q6	285	25	.	.	.
cord-326228-9x1233q6	286	1	How	how	WRB
cord-326228-9x1233q6	286	2	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	286	3	recognises	recognise	VBZ
cord-326228-9x1233q6	286	4	mtDNA	mtdna	NN
cord-326228-9x1233q6	286	5	in	in	IN
cord-326228-9x1233q6	286	6	a	a	DT
cord-326228-9x1233q6	286	7	physiological	physiological	JJ
cord-326228-9x1233q6	286	8	context	context	NN
cord-326228-9x1233q6	286	9	beyond	beyond	IN
cord-326228-9x1233q6	286	10	in	in	FW
cord-326228-9x1233q6	286	11	vitro	vitro	FW
cord-326228-9x1233q6	286	12	assays	assay	NNS
cord-326228-9x1233q6	286	13	remains	remain	VBZ
cord-326228-9x1233q6	286	14	to	to	TO
cord-326228-9x1233q6	286	15	be	be	VB
cord-326228-9x1233q6	286	16	seen	see	VBN
cord-326228-9x1233q6	286	17	and	and	CC
cord-326228-9x1233q6	286	18	will	will	MD
cord-326228-9x1233q6	286	19	no	no	RB
cord-326228-9x1233q6	286	20	doubt	doubt	RB
cord-326228-9x1233q6	286	21	be	be	VB
cord-326228-9x1233q6	286	22	an	an	DT
cord-326228-9x1233q6	286	23	important	important	JJ
cord-326228-9x1233q6	286	24	future	future	JJ
cord-326228-9x1233q6	286	25	addition	addition	NN
cord-326228-9x1233q6	286	26	to	to	IN
cord-326228-9x1233q6	286	27	the	the	DT
cord-326228-9x1233q6	286	28	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	286	29	field	field	NN
cord-326228-9x1233q6	286	30	.	.	.
cord-326228-9x1233q6	287	1	Mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	287	2	are	be	VBP
cord-326228-9x1233q6	287	3	ATP	ATP	NNP
cord-326228-9x1233q6	287	4	factories	factory	NNS
cord-326228-9x1233q6	287	5	,	,	,
cord-326228-9x1233q6	287	6	as	as	RB
cord-326228-9x1233q6	287	7	well	well	RB
cord-326228-9x1233q6	287	8	as	as	IN
cord-326228-9x1233q6	287	9	reservoirs	reservoir	NNS
cord-326228-9x1233q6	287	10	for	for	IN
cord-326228-9x1233q6	287	11	PAMP	PAMP	NNP
cord-326228-9x1233q6	287	12	-	-	HYPH
cord-326228-9x1233q6	287	13	like	like	JJ
cord-326228-9x1233q6	287	14	molecules	molecule	NNS
cord-326228-9x1233q6	287	15	.	.	.
cord-326228-9x1233q6	288	1	Links	link	NNS
cord-326228-9x1233q6	288	2	between	between	IN
cord-326228-9x1233q6	288	3	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	288	4	dysfunction	dysfunction	NN
cord-326228-9x1233q6	288	5	and	and	CC
cord-326228-9x1233q6	288	6	NLRP3	nlrp3	NN
cord-326228-9x1233q6	288	7	activation	activation	NN
cord-326228-9x1233q6	288	8	are	be	VBP
cord-326228-9x1233q6	288	9	now	now	RB
cord-326228-9x1233q6	288	10	irrefutable	irrefutable	JJ
cord-326228-9x1233q6	288	11	,	,	,
cord-326228-9x1233q6	288	12	but	but	CC
cord-326228-9x1233q6	288	13	raise	raise	VB
cord-326228-9x1233q6	288	14	several	several	JJ
cord-326228-9x1233q6	288	15	further	further	JJ
cord-326228-9x1233q6	288	16	questions	question	NNS
cord-326228-9x1233q6	288	17	.	.	.
cord-326228-9x1233q6	289	1	One	one	CD
cord-326228-9x1233q6	289	2	such	such	JJ
cord-326228-9x1233q6	289	3	hot	hot	JJ
cord-326228-9x1233q6	289	4	topic	topic	NN
cord-326228-9x1233q6	289	5	is	be	VBZ
cord-326228-9x1233q6	289	6	the	the	DT
cord-326228-9x1233q6	289	7	mechanism	mechanism	NN
cord-326228-9x1233q6	289	8	by	by	IN
cord-326228-9x1233q6	289	9	which	which	WDT
cord-326228-9x1233q6	289	10	NLRP3	nlrp3	NN
cord-326228-9x1233q6	289	11	senses	sense	VBZ
cord-326228-9x1233q6	289	12	cytosolic	cytosolic	JJ
cord-326228-9x1233q6	289	13	mtDNA	mtdna	NN
cord-326228-9x1233q6	289	14	.	.	.
cord-326228-9x1233q6	290	1	Our	-PRON-	PRP$
cord-326228-9x1233q6	290	2	understanding	understanding	NN
cord-326228-9x1233q6	290	3	of	of	IN
cord-326228-9x1233q6	290	4	this	this	DT
cord-326228-9x1233q6	290	5	process	process	NN
cord-326228-9x1233q6	290	6	is	be	VBZ
cord-326228-9x1233q6	290	7	complicated	complicate	VBN
cord-326228-9x1233q6	290	8	by	by	IN
cord-326228-9x1233q6	290	9	the	the	DT
cord-326228-9x1233q6	290	10	many	many	JJ
cord-326228-9x1233q6	290	11	links	link	NNS
cord-326228-9x1233q6	290	12	between	between	IN
cord-326228-9x1233q6	290	13	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	290	14	processes	process	NNS
cord-326228-9x1233q6	290	15	and	and	CC
cord-326228-9x1233q6	290	16	inflammasome	inflammasome	NN
cord-326228-9x1233q6	290	17	signalling	signalling	NN
cord-326228-9x1233q6	290	18	,	,	,
cord-326228-9x1233q6	290	19	both	both	DT
cord-326228-9x1233q6	290	20	up	up	RB
cord-326228-9x1233q6	290	21	-	-	HYPH
cord-326228-9x1233q6	290	22	and	and	CC
cord-326228-9x1233q6	290	23	downstream	downstream	RB
cord-326228-9x1233q6	290	24	of	of	IN
cord-326228-9x1233q6	290	25	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	290	26	activation	activation	NN
cord-326228-9x1233q6	290	27	.	.	.
cord-326228-9x1233q6	291	1	Our	-PRON-	PRP$
cord-326228-9x1233q6	291	2	emerging	emerge	VBG
cord-326228-9x1233q6	291	3	understanding	understanding	NN
cord-326228-9x1233q6	291	4	of	of	IN
cord-326228-9x1233q6	291	5	ER	er	NN
cord-326228-9x1233q6	291	6	-	-	HYPH
cord-326228-9x1233q6	291	7	mitochondria	mitochondria	NN
cord-326228-9x1233q6	291	8	dynamics	dynamic	NNS
cord-326228-9x1233q6	291	9	,	,	,
cord-326228-9x1233q6	291	10	including	include	VBG
cord-326228-9x1233q6	291	11	the	the	DT
cord-326228-9x1233q6	291	12	important	important	JJ
cord-326228-9x1233q6	291	13	signalling	signalling	NN
cord-326228-9x1233q6	291	14	functions	function	NNS
cord-326228-9x1233q6	291	15	of	of	IN
cord-326228-9x1233q6	291	16	MAMs	mam	NNS
cord-326228-9x1233q6	291	17	,	,	,
cord-326228-9x1233q6	291	18	suggests	suggest	VBZ
cord-326228-9x1233q6	291	19	it	-PRON-	PRP
cord-326228-9x1233q6	291	20	may	may	MD
cord-326228-9x1233q6	291	21	be	be	VB
cord-326228-9x1233q6	291	22	prudent	prudent	JJ
cord-326228-9x1233q6	291	23	for	for	IN
cord-326228-9x1233q6	291	24	future	future	JJ
cord-326228-9x1233q6	291	25	studies	study	NNS
cord-326228-9x1233q6	291	26	to	to	TO
cord-326228-9x1233q6	291	27	consider	consider	VB
cord-326228-9x1233q6	291	28	the	the	DT
cord-326228-9x1233q6	291	29	ER	er	NN
cord-326228-9x1233q6	291	30	and	and	CC
cord-326228-9x1233q6	291	31	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	291	32	together	together	RB
cord-326228-9x1233q6	291	33	,	,	,
cord-326228-9x1233q6	291	34	rather	rather	RB
cord-326228-9x1233q6	291	35	than	than	IN
cord-326228-9x1233q6	291	36	in	in	IN
cord-326228-9x1233q6	291	37	isolation	isolation	NN
cord-326228-9x1233q6	291	38	.	.	.
cord-326228-9x1233q6	292	1	Continued	continue	VBN
cord-326228-9x1233q6	292	2	advances	advance	NNS
cord-326228-9x1233q6	292	3	in	in	IN
cord-326228-9x1233q6	292	4	high	high	JJ
cord-326228-9x1233q6	292	5	-	-	HYPH
cord-326228-9x1233q6	292	6	resolution	resolution	NN
cord-326228-9x1233q6	292	7	spatiotemporal	spatiotemporal	JJ
cord-326228-9x1233q6	292	8	imaging	imaging	NN
cord-326228-9x1233q6	292	9	techniques	technique	NNS
cord-326228-9x1233q6	292	10	are	be	VBP
cord-326228-9x1233q6	292	11	likely	likely	JJ
cord-326228-9x1233q6	292	12	to	to	TO
cord-326228-9x1233q6	292	13	yield	yield	VB
cord-326228-9x1233q6	292	14	important	important	JJ
cord-326228-9x1233q6	292	15	insight	insight	NN
cord-326228-9x1233q6	292	16	into	into	IN
cord-326228-9x1233q6	292	17	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	292	18	and	and	CC
cord-326228-9x1233q6	292	19	ER	ER	NNP
cord-326228-9x1233q6	292	20	dynamics	dynamic	NNS
cord-326228-9x1233q6	292	21	prior	prior	RB
cord-326228-9x1233q6	292	22	to	to	IN
cord-326228-9x1233q6	292	23	,	,	,
cord-326228-9x1233q6	292	24	and	and	CC
cord-326228-9x1233q6	292	25	during	during	IN
cord-326228-9x1233q6	292	26	,	,	.
cord-326228-9x1233q6	293	1	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	293	2	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	293	3	signalling	signal	VBG
cord-326228-9x1233q6	293	4	.	.	.
cord-326228-9x1233q6	294	1	As	as	IN
cord-326228-9x1233q6	294	2	many	many	JJ
cord-326228-9x1233q6	294	3	current	current	JJ
cord-326228-9x1233q6	294	4	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	294	5	labelling	labelling	NN
cord-326228-9x1233q6	294	6	strategies	strategy	NNS
cord-326228-9x1233q6	294	7	interfere	interfere	VBP
cord-326228-9x1233q6	294	8	with	with	IN
cord-326228-9x1233q6	294	9	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	294	10	function	function	NN
cord-326228-9x1233q6	294	11	to	to	IN
cord-326228-9x1233q6	294	12	some	some	DT
cord-326228-9x1233q6	294	13	degree	degree	NN
cord-326228-9x1233q6	294	14	,	,	,
cord-326228-9x1233q6	294	15	a	a	DT
cord-326228-9x1233q6	294	16	particular	particular	JJ
cord-326228-9x1233q6	294	17	challenge	challenge	NN
cord-326228-9x1233q6	294	18	will	will	MD
cord-326228-9x1233q6	294	19	be	be	VB
cord-326228-9x1233q6	294	20	to	to	TO
cord-326228-9x1233q6	294	21	develop	develop	VB
cord-326228-9x1233q6	294	22	techniques	technique	NNS
cord-326228-9x1233q6	294	23	for	for	IN
cord-326228-9x1233q6	294	24	live	live	JJ
cord-326228-9x1233q6	294	25	-	-	HYPH
cord-326228-9x1233q6	294	26	cell	cell	NN
cord-326228-9x1233q6	294	27	monitoring	monitoring	NN
cord-326228-9x1233q6	294	28	of	of	IN
cord-326228-9x1233q6	294	29	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	294	30	without	without	IN
cord-326228-9x1233q6	294	31	affecting	affect	VBG
cord-326228-9x1233q6	294	32	their	-PRON-	PRP$
cord-326228-9x1233q6	294	33	metabolic	metabolic	JJ
cord-326228-9x1233q6	294	34	function	function	NN
cord-326228-9x1233q6	294	35	,	,	,
cord-326228-9x1233q6	294	36	morphology	morphology	NN
cord-326228-9x1233q6	294	37	or	or	CC
cord-326228-9x1233q6	294	38	membrane	membrane	NN
cord-326228-9x1233q6	294	39	potential	potential	NN
cord-326228-9x1233q6	294	40	.	.	.
cord-326228-9x1233q6	295	1	We	-PRON-	PRP
cord-326228-9x1233q6	295	2	predict	predict	VBP
cord-326228-9x1233q6	295	3	that	that	IN
cord-326228-9x1233q6	295	4	future	future	JJ
cord-326228-9x1233q6	295	5	exciting	exciting	JJ
cord-326228-9x1233q6	295	6	discoveries	discovery	NNS
cord-326228-9x1233q6	295	7	will	will	MD
cord-326228-9x1233q6	295	8	include	include	VB
cord-326228-9x1233q6	295	9	the	the	DT
cord-326228-9x1233q6	295	10	specific	specific	JJ
cord-326228-9x1233q6	295	11	mechanisms	mechanism	NNS
cord-326228-9x1233q6	295	12	underpinning	underpin	VBG
cord-326228-9x1233q6	295	13	mtDNA	mtdna	JJ
cord-326228-9x1233q6	295	14	recognition	recognition	NN
cord-326228-9x1233q6	295	15	by	by	IN
cord-326228-9x1233q6	295	16	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	295	17	,	,	,
cord-326228-9x1233q6	295	18	in	in	IN
cord-326228-9x1233q6	295	19	vivo	vivo	NN
cord-326228-9x1233q6	295	20	and	and	CC
cord-326228-9x1233q6	295	21	in	in	IN
cord-326228-9x1233q6	295	22	vitro	vitro	FW
cord-326228-9x1233q6	295	23	,	,	,
cord-326228-9x1233q6	295	24	and	and	CC
cord-326228-9x1233q6	295	25	in	in	IN
cord-326228-9x1233q6	295	26	disease	disease	NN
cord-326228-9x1233q6	295	27	and	and	CC
cord-326228-9x1233q6	295	28	health	health	NN
cord-326228-9x1233q6	295	29	.	.	.
cord-326228-9x1233q6	296	1	Mechanisms	mechanism	NNS
cord-326228-9x1233q6	296	2	and	and	CC
cord-326228-9x1233q6	296	3	outcomes	outcome	NNS
cord-326228-9x1233q6	296	4	of	of	IN
cord-326228-9x1233q6	296	5	signal	signal	NN
cord-326228-9x1233q6	296	6	integration	integration	NN
cord-326228-9x1233q6	296	7	by	by	IN
cord-326228-9x1233q6	296	8	the	the	DT
cord-326228-9x1233q6	296	9	suite	suite	NN
cord-326228-9x1233q6	296	10	of	of	IN
cord-326228-9x1233q6	296	11	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	296	12	-	-	HYPH
cord-326228-9x1233q6	296	13	activated	activate	VBN
cord-326228-9x1233q6	296	14	PRRs	prr	NNS
cord-326228-9x1233q6	296	15	,	,	,
cord-326228-9x1233q6	296	16	such	such	JJ
cord-326228-9x1233q6	296	17	as	as	IN
cord-326228-9x1233q6	296	18	cGAS	cgas	NN
cord-326228-9x1233q6	296	19	,	,	,
cord-326228-9x1233q6	296	20	AIM2	AIM2	NNP
cord-326228-9x1233q6	296	21	,	,	,
cord-326228-9x1233q6	296	22	NLRP3	nlrp3	NN
cord-326228-9x1233q6	296	23	and	and	CC
cord-326228-9x1233q6	296	24	TLR9	TLR9	NNP
cord-326228-9x1233q6	296	25	,	,	,
cord-326228-9x1233q6	296	26	will	will	MD
cord-326228-9x1233q6	296	27	also	also	RB
cord-326228-9x1233q6	296	28	be	be	VB
cord-326228-9x1233q6	296	29	of	of	IN
cord-326228-9x1233q6	296	30	prominent	prominent	JJ
cord-326228-9x1233q6	296	31	interest	interest	NN
cord-326228-9x1233q6	296	32	.	.	.
cord-326228-9x1233q6	297	1	Despite	despite	IN
cord-326228-9x1233q6	297	2	the	the	DT
cord-326228-9x1233q6	297	3	technical	technical	JJ
cord-326228-9x1233q6	297	4	challenges	challenge	NNS
cord-326228-9x1233q6	297	5	,	,	,
cord-326228-9x1233q6	297	6	this	this	DT
cord-326228-9x1233q6	297	7	topic	topic	NN
cord-326228-9x1233q6	297	8	promises	promise	VBZ
cord-326228-9x1233q6	297	9	to	to	TO
cord-326228-9x1233q6	297	10	be	be	VB
cord-326228-9x1233q6	297	11	an	an	DT
cord-326228-9x1233q6	297	12	exciting	exciting	JJ
cord-326228-9x1233q6	297	13	area	area	NN
cord-326228-9x1233q6	297	14	in	in	IN
cord-326228-9x1233q6	297	15	the	the	DT
cord-326228-9x1233q6	297	16	coming	come	VBG
cord-326228-9x1233q6	297	17	years	year	NNS
cord-326228-9x1233q6	297	18	.	.	.
cord-326228-9x1233q6	298	1	Mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	298	2	evolution	evolution	NN
cord-326228-9x1233q6	299	1	Innate	innate	JJ
cord-326228-9x1233q6	299	2	immunity	immunity	NN
cord-326228-9x1233q6	299	3	and	and	CC
cord-326228-9x1233q6	299	4	tolerance	tolerance	NN
cord-326228-9x1233q6	299	5	toward	toward	IN
cord-326228-9x1233q6	299	6	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	299	7	Targeting	target	VBG
cord-326228-9x1233q6	299	8	the	the	DT
cord-326228-9x1233q6	299	9	NLRP3	nlrp3	NN
cord-326228-9x1233q6	299	10	inflammasome	inflammasome	NN
cord-326228-9x1233q6	299	11	in	in	IN
cord-326228-9x1233q6	299	12	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	299	13	diseases	disease	NNS
cord-326228-9x1233q6	300	1	The	the	DT
cord-326228-9x1233q6	300	2	inflammasomes	inflammasome	NNS
cord-326228-9x1233q6	301	1	Inflammasome	Inflammasome	NNP
cord-326228-9x1233q6	301	2	-	-	HYPH
cord-326228-9x1233q6	301	3	activated	activate	VBN
cord-326228-9x1233q6	301	4	gasdermin	gasdermin	NNP
cord-326228-9x1233q6	301	5	D	D	NNP
cord-326228-9x1233q6	301	6	causes	cause	VBZ
cord-326228-9x1233q6	301	7	pyroptosis	pyroptosis	NN
cord-326228-9x1233q6	301	8	by	by	IN
cord-326228-9x1233q6	301	9	forming	form	VBG
cord-326228-9x1233q6	301	10	membrane	membrane	NN
cord-326228-9x1233q6	301	11	pores	pore	NNS
cord-326228-9x1233q6	301	12	Right	right	JJ
cord-326228-9x1233q6	301	13	place	place	NN
cord-326228-9x1233q6	301	14	,	,	,
cord-326228-9x1233q6	301	15	right	right	JJ
cord-326228-9x1233q6	301	16	time	time	NN
cord-326228-9x1233q6	301	17	:	:	:
cord-326228-9x1233q6	301	18	localisation	localisation	NN
cord-326228-9x1233q6	301	19	and	and	CC
cord-326228-9x1233q6	301	20	assembly	assembly	NN
cord-326228-9x1233q6	301	21	of	of	IN
cord-326228-9x1233q6	301	22	the	the	DT
cord-326228-9x1233q6	301	23	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	301	24	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	301	25	PtdIns4P	PtdIns4P	NNP
cord-326228-9x1233q6	301	26	on	on	IN
cord-326228-9x1233q6	301	27	dispersed	disperse	VBN
cord-326228-9x1233q6	301	28	trans	trans	NNP
cord-326228-9x1233q6	301	29	-	-	NNP
cord-326228-9x1233q6	301	30	Golgi	Golgi	NNP
cord-326228-9x1233q6	301	31	network	network	NN
cord-326228-9x1233q6	302	1	mediates	mediate	VBZ
cord-326228-9x1233q6	302	2	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	302	3	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	302	4	activation	activation	NN
cord-326228-9x1233q6	302	5	Molecular	Molecular	NNP
cord-326228-9x1233q6	302	6	mechanisms	mechanism	NNS
cord-326228-9x1233q6	302	7	regulating	regulate	VBG
cord-326228-9x1233q6	302	8	NLRP3	nlrp3	XX
cord-326228-9x1233q6	303	1	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	303	2	activation	activation	NNP
cord-326228-9x1233q6	304	1	K	K	NNP
cord-326228-9x1233q6	304	2	+	+	CC
cord-326228-9x1233q6	304	3	Efflux	Efflux	NNP
cord-326228-9x1233q6	304	4	-	-	HYPH
cord-326228-9x1233q6	304	5	Independent	Independent	NNP
cord-326228-9x1233q6	304	6	NLRP3	nlrp3	NN
cord-326228-9x1233q6	304	7	inflammasome	inflammasome	NN
cord-326228-9x1233q6	304	8	activation	activation	NN
cord-326228-9x1233q6	304	9	by	by	IN
cord-326228-9x1233q6	304	10	small	small	JJ
cord-326228-9x1233q6	304	11	molecules	molecule	NNS
cord-326228-9x1233q6	304	12	targeting	target	VBG
cord-326228-9x1233q6	304	13	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	305	1	The	the	DT
cord-326228-9x1233q6	305	2	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	305	3	apoptotic	apoptotic	JJ
cord-326228-9x1233q6	305	4	effectors	effector	NNS
cord-326228-9x1233q6	305	5	BAX	BAX	NNP
cord-326228-9x1233q6	305	6	/	/	SYM
cord-326228-9x1233q6	305	7	BAK	BAK	NNP
cord-326228-9x1233q6	305	8	activate	activate	VB
cord-326228-9x1233q6	305	9	caspase-3	caspase-3	NNP
cord-326228-9x1233q6	305	10	and	and	CC
cord-326228-9x1233q6	305	11	-7	-7	NNP
cord-326228-9x1233q6	305	12	to	to	TO
cord-326228-9x1233q6	305	13	trigger	trigger	VB
cord-326228-9x1233q6	305	14	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	305	15	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	305	16	and	and	CC
cord-326228-9x1233q6	305	17	caspase-8	caspase-8	NNP
cord-326228-9x1233q6	305	18	driven	drive	VBN
cord-326228-9x1233q6	305	19	IL-1b	IL-1b	NNP
cord-326228-9x1233q6	305	20	activation	activation	NN
cord-326228-9x1233q6	306	1	The	the	DT
cord-326228-9x1233q6	306	2	adaptor	adaptor	NN
cord-326228-9x1233q6	306	3	MAVS	MAVS	NNP
cord-326228-9x1233q6	306	4	promotes	promote	VBZ
cord-326228-9x1233q6	307	1	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	307	2	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	307	3	localization	localization	NN
cord-326228-9x1233q6	307	4	and	and	CC
cord-326228-9x1233q6	307	5	inflammasome	inflammasome	NN
cord-326228-9x1233q6	307	6	activation	activation	NN
cord-326228-9x1233q6	307	7	Thioredoxin	Thioredoxin	NNP
cord-326228-9x1233q6	307	8	-	-	HYPH
cord-326228-9x1233q6	307	9	interacting	interact	VBG
cord-326228-9x1233q6	307	10	protein	protein	NN
cord-326228-9x1233q6	307	11	is	be	VBZ
cord-326228-9x1233q6	307	12	required	require	VBN
cord-326228-9x1233q6	307	13	for	for	IN
cord-326228-9x1233q6	307	14	endothelial	endothelial	JJ
cord-326228-9x1233q6	307	15	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	307	16	inflammasome	inflammasome	NN
cord-326228-9x1233q6	307	17	activation	activation	NN
cord-326228-9x1233q6	307	18	and	and	CC
cord-326228-9x1233q6	307	19	cell	cell	NN
cord-326228-9x1233q6	307	20	death	death	NN
cord-326228-9x1233q6	307	21	in	in	IN
cord-326228-9x1233q6	307	22	a	a	DT
cord-326228-9x1233q6	307	23	rat	rat	NN
cord-326228-9x1233q6	307	24	model	model	NN
cord-326228-9x1233q6	307	25	of	of	IN
cord-326228-9x1233q6	307	26	high	high	JJ
cord-326228-9x1233q6	307	27	-	-	HYPH
cord-326228-9x1233q6	307	28	fat	fat	NN
cord-326228-9x1233q6	307	29	diet	diet	NN
cord-326228-9x1233q6	307	30	Mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	307	31	cardiolipin	cardiolipin	NNP
cord-326228-9x1233q6	307	32	is	be	VBZ
cord-326228-9x1233q6	307	33	required	require	VBN
cord-326228-9x1233q6	307	34	for	for	IN
cord-326228-9x1233q6	307	35	Nlrp3	Nlrp3	NNP
cord-326228-9x1233q6	308	1	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	308	2	activation	activation	NN
cord-326228-9x1233q6	308	3	Oxidized	oxidize	VBN
cord-326228-9x1233q6	308	4	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	308	5	DNA	dna	NN
cord-326228-9x1233q6	308	6	activates	activate	VBZ
cord-326228-9x1233q6	308	7	the	the	DT
cord-326228-9x1233q6	308	8	NLRP3	nlrp3	XX
cord-326228-9x1233q6	308	9	inflammasome	inflammasome	NN
cord-326228-9x1233q6	308	10	during	during	IN
cord-326228-9x1233q6	308	11	apoptosis	apoptosis	NN
cord-326228-9x1233q6	308	12	Mitochondria	Mitochondria	NNP
cord-326228-9x1233q6	308	13	protection	protection	NN
cord-326228-9x1233q6	308	14	after	after	IN
cord-326228-9x1233q6	308	15	acute	acute	JJ
cord-326228-9x1233q6	308	16	ischemia	ischemia	NN
cord-326228-9x1233q6	308	17	prevents	prevent	VBZ
cord-326228-9x1233q6	308	18	prolonged	prolong	VBN
cord-326228-9x1233q6	308	19	upregulation	upregulation	NN
cord-326228-9x1233q6	308	20	of	of	IN
cord-326228-9x1233q6	308	21	IL-1b	IL-1b	NNS
cord-326228-9x1233q6	308	22	and	and	CC
cord-326228-9x1233q6	308	23	IL-18	IL-18	NNP
cord-326228-9x1233q6	308	24	and	and	CC
cord-326228-9x1233q6	308	25	arrests	arrest	VBZ
cord-326228-9x1233q6	308	26	CKD	CKD	NNP
cord-326228-9x1233q6	308	27	Evolution	Evolution	NNP
cord-326228-9x1233q6	308	28	of	of	IN
cord-326228-9x1233q6	308	29	the	the	DT
cord-326228-9x1233q6	308	30	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	308	31	fusion	fusion	NN
cord-326228-9x1233q6	308	32	-	-	HYPH
cord-326228-9x1233q6	308	33	fission	fission	NN
cord-326228-9x1233q6	308	34	cycle	cycle	NN
cord-326228-9x1233q6	308	35	and	and	CC
cord-326228-9x1233q6	308	36	its	-PRON-	PRP$
cord-326228-9x1233q6	308	37	role	role	NN
cord-326228-9x1233q6	308	38	in	in	IN
cord-326228-9x1233q6	308	39	aging	age	VBG
cord-326228-9x1233q6	308	40	Fission	fission	NN
cord-326228-9x1233q6	308	41	and	and	CC
cord-326228-9x1233q6	308	42	selective	selective	JJ
cord-326228-9x1233q6	308	43	fusion	fusion	NN
cord-326228-9x1233q6	308	44	govern	govern	VBP
cord-326228-9x1233q6	308	45	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	308	46	segregation	segregation	NN
cord-326228-9x1233q6	308	47	and	and	CC
cord-326228-9x1233q6	308	48	elimination	elimination	NN
cord-326228-9x1233q6	308	49	by	by	IN
cord-326228-9x1233q6	308	50	autophagy	autophagy	NN
cord-326228-9x1233q6	308	51	Mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	308	52	fission	fission	NN
cord-326228-9x1233q6	308	53	facilitates	facilitate	VBZ
cord-326228-9x1233q6	308	54	the	the	DT
cord-326228-9x1233q6	308	55	selective	selective	JJ
cord-326228-9x1233q6	308	56	mitophagy	mitophagy	NN
cord-326228-9x1233q6	308	57	of	of	IN
cord-326228-9x1233q6	308	58	protein	protein	NN
cord-326228-9x1233q6	308	59	aggregates	aggregate	NNS
cord-326228-9x1233q6	308	60	elegans	elegan	VBZ
cord-326228-9x1233q6	308	61	dynamin	dynamin	NNP
cord-326228-9x1233q6	308	62	-	-	HYPH
cord-326228-9x1233q6	308	63	related	relate	VBN
cord-326228-9x1233q6	308	64	protein	protein	NN
cord-326228-9x1233q6	308	65	DRP-1	DRP-1	NNP
cord-326228-9x1233q6	308	66	controls	control	VBZ
cord-326228-9x1233q6	308	67	severing	severing	NN
cord-326228-9x1233q6	308	68	of	of	IN
cord-326228-9x1233q6	308	69	the	the	DT
cord-326228-9x1233q6	308	70	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	308	71	outer	outer	JJ
cord-326228-9x1233q6	308	72	membrane	membrane	NN
cord-326228-9x1233q6	308	73	Dnm1	Dnm1	NNP
cord-326228-9x1233q6	308	74	forms	form	NNS
cord-326228-9x1233q6	308	75	spirals	spiral	NNS
cord-326228-9x1233q6	308	76	that	that	WDT
cord-326228-9x1233q6	308	77	are	be	VBP
cord-326228-9x1233q6	308	78	structurally	structurally	RB
cord-326228-9x1233q6	308	79	tailored	tailor	VBN
cord-326228-9x1233q6	308	80	to	to	TO
cord-326228-9x1233q6	308	81	fit	fit	VB
cord-326228-9x1233q6	308	82	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	308	83	ER	ER	NNP
cord-326228-9x1233q6	308	84	tubules	tubule	NNS
cord-326228-9x1233q6	308	85	mark	mark	VBP
cord-326228-9x1233q6	308	86	sites	site	NNS
cord-326228-9x1233q6	308	87	of	of	IN
cord-326228-9x1233q6	308	88	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	308	89	division	division	NN
cord-326228-9x1233q6	308	90	Actin	Actin	NNP
cord-326228-9x1233q6	308	91	filaments	filament	NNS
cord-326228-9x1233q6	308	92	target	target	VBP
cord-326228-9x1233q6	308	93	the	the	DT
cord-326228-9x1233q6	308	94	oligomeric	oligomeric	JJ
cord-326228-9x1233q6	308	95	maturation	maturation	NN
cord-326228-9x1233q6	308	96	of	of	IN
cord-326228-9x1233q6	308	97	the	the	DT
cord-326228-9x1233q6	308	98	dynamin	dynamin	NN
cord-326228-9x1233q6	308	99	GTPase	GTPase	NNP
cord-326228-9x1233q6	308	100	Drp1	Drp1	NNP
cord-326228-9x1233q6	308	101	to	to	TO
cord-326228-9x1233q6	308	102	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	308	103	fission	fission	NN
cord-326228-9x1233q6	308	104	sites	site	NNS
cord-326228-9x1233q6	309	1	The	the	DT
cord-326228-9x1233q6	309	2	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	309	3	phosphatase	phosphatase	NN
cord-326228-9x1233q6	309	4	PGAM5	pgam5	NN
cord-326228-9x1233q6	309	5	is	be	VBZ
cord-326228-9x1233q6	309	6	dispensable	dispensable	JJ
cord-326228-9x1233q6	309	7	for	for	IN
cord-326228-9x1233q6	309	8	necroptosis	necroptosis	NNP
cord-326228-9x1233q6	309	9	but	but	CC
cord-326228-9x1233q6	309	10	promotes	promote	VBZ
cord-326228-9x1233q6	309	11	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	309	12	activation	activation	NN
cord-326228-9x1233q6	309	13	in	in	IN
cord-326228-9x1233q6	309	14	macrophages	macrophage	NNS
cord-326228-9x1233q6	310	1	The	the	DT
cord-326228-9x1233q6	310	2	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	310	3	phosphatase	phosphatase	NN
cord-326228-9x1233q6	310	4	PGAM5	pgam5	NN
cord-326228-9x1233q6	310	5	functions	function	NNS
cord-326228-9x1233q6	310	6	at	at	IN
cord-326228-9x1233q6	310	7	the	the	DT
cord-326228-9x1233q6	310	8	convergence	convergence	NN
cord-326228-9x1233q6	310	9	point	point	NN
cord-326228-9x1233q6	310	10	of	of	IN
cord-326228-9x1233q6	310	11	multiple	multiple	JJ
cord-326228-9x1233q6	310	12	necrotic	necrotic	JJ
cord-326228-9x1233q6	310	13	death	death	NN
cord-326228-9x1233q6	310	14	pathways	pathway	NNS
cord-326228-9x1233q6	310	15	Loss	Loss	NNP
cord-326228-9x1233q6	310	16	of	of	IN
cord-326228-9x1233q6	310	17	OPA1	OPA1	NNP
cord-326228-9x1233q6	311	1	perturbates	perturbate	VBZ
cord-326228-9x1233q6	311	2	the	the	DT
cord-326228-9x1233q6	311	3	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	311	4	inner	inner	JJ
cord-326228-9x1233q6	311	5	membrane	membrane	NN
cord-326228-9x1233q6	311	6	structure	structure	NN
cord-326228-9x1233q6	311	7	and	and	CC
cord-326228-9x1233q6	311	8	integrity	integrity	NN
cord-326228-9x1233q6	311	9	,	,	,
cord-326228-9x1233q6	311	10	leading	lead	VBG
cord-326228-9x1233q6	311	11	to	to	IN
cord-326228-9x1233q6	311	12	cytochrome	cytochrome	NN
cord-326228-9x1233q6	311	13	c	c	NN
cord-326228-9x1233q6	311	14	release	release	NN
cord-326228-9x1233q6	311	15	and	and	CC
cord-326228-9x1233q6	311	16	apoptosis	apoptosis	NN
cord-326228-9x1233q6	311	17	The	the	DT
cord-326228-9x1233q6	311	18	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	311	19	inner	inner	JJ
cord-326228-9x1233q6	311	20	membrane	membrane	NN
cord-326228-9x1233q6	311	21	GTPase	GTPase	NNP
cord-326228-9x1233q6	311	22	,	,	,
cord-326228-9x1233q6	311	23	optic	optic	JJ
cord-326228-9x1233q6	311	24	atrophy	atrophy	NN
cord-326228-9x1233q6	311	25	1	1	CD
cord-326228-9x1233q6	311	26	(	(	-LRB-
cord-326228-9x1233q6	311	27	Opa1	Opa1	NNP
cord-326228-9x1233q6	311	28	)	)	-RRB-
cord-326228-9x1233q6	311	29	,	,	.
cord-326228-9x1233q6	312	1	restores	restore	VBZ
cord-326228-9x1233q6	312	2	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	312	3	morphology	morphology	NN
cord-326228-9x1233q6	312	4	and	and	CC
cord-326228-9x1233q6	312	5	promotes	promote	VBZ
cord-326228-9x1233q6	312	6	neuronal	neuronal	JJ
cord-326228-9x1233q6	312	7	survival	survival	NN
cord-326228-9x1233q6	312	8	following	follow	VBG
cord-326228-9x1233q6	312	9	excitotoxicity	excitotoxicity	NN
cord-326228-9x1233q6	312	10	Dominant	dominant	JJ
cord-326228-9x1233q6	312	11	optic	optic	JJ
cord-326228-9x1233q6	312	12	atrophy	atrophy	NN
cord-326228-9x1233q6	312	13	,	,	,
cord-326228-9x1233q6	312	14	OPA1	OPA1	NNP
cord-326228-9x1233q6	312	15	,	,	,
cord-326228-9x1233q6	312	16	and	and	CC
cord-326228-9x1233q6	312	17	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	312	18	quality	quality	NN
cord-326228-9x1233q6	312	19	control	control	NN
cord-326228-9x1233q6	312	20	:	:	:
cord-326228-9x1233q6	313	1	understanding	understand	VBG
cord-326228-9x1233q6	313	2	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	313	3	network	network	NN
cord-326228-9x1233q6	313	4	dynamics	dynamic	NNS
cord-326228-9x1233q6	314	1	Mitofusins	Mitofusins	NNP
cord-326228-9x1233q6	314	2	Mfn1	Mfn1	NNP
cord-326228-9x1233q6	314	3	and	and	CC
cord-326228-9x1233q6	314	4	Mfn2	Mfn2	NNP
cord-326228-9x1233q6	314	5	coordinately	coordinately	NN
cord-326228-9x1233q6	314	6	regulate	regulate	VB
cord-326228-9x1233q6	314	7	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	314	8	fusion	fusion	NN
cord-326228-9x1233q6	314	9	and	and	CC
cord-326228-9x1233q6	314	10	are	be	VBP
cord-326228-9x1233q6	314	11	essential	essential	JJ
cord-326228-9x1233q6	314	12	for	for	IN
cord-326228-9x1233q6	314	13	embryonic	embryonic	JJ
cord-326228-9x1233q6	314	14	development	development	NN
cord-326228-9x1233q6	314	15	Mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	314	16	fusion	fusion	NN
cord-326228-9x1233q6	314	17	in	in	IN
cord-326228-9x1233q6	314	18	yeast	yeast	NN
cord-326228-9x1233q6	314	19	requires	require	VBZ
cord-326228-9x1233q6	314	20	the	the	DT
cord-326228-9x1233q6	314	21	transmembrane	transmembrane	NN
cord-326228-9x1233q6	314	22	GTPase	GTPase	NNP
cord-326228-9x1233q6	314	23	Fzo1p	Fzo1p	NNP
cord-326228-9x1233q6	314	24	Mitochondrial	Mitochondrial	NNP
cord-326228-9x1233q6	314	25	fission	fission	NN
cord-326228-9x1233q6	314	26	,	,	,
cord-326228-9x1233q6	314	27	fusion	fusion	NN
cord-326228-9x1233q6	314	28	,	,	,
cord-326228-9x1233q6	314	29	and	and	CC
cord-326228-9x1233q6	314	30	stress	stress	NN
cord-326228-9x1233q6	314	31	Dengue	Dengue	NNP
cord-326228-9x1233q6	314	32	virus	virus	NN
cord-326228-9x1233q6	314	33	perturbs	perturb	VBZ
cord-326228-9x1233q6	314	34	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	314	35	morphodynamics	morphodynamic	NNS
cord-326228-9x1233q6	314	36	to	to	TO
cord-326228-9x1233q6	314	37	dampen	dampen	VB
cord-326228-9x1233q6	314	38	innate	innate	JJ
cord-326228-9x1233q6	314	39	immune	immune	JJ
cord-326228-9x1233q6	314	40	responses	response	NNS
cord-326228-9x1233q6	314	41	Dengue	Dengue	NNP
cord-326228-9x1233q6	314	42	virus	virus	NN
cord-326228-9x1233q6	314	43	induces	induce	VBZ
cord-326228-9x1233q6	314	44	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	314	45	elongation	elongation	NN
cord-326228-9x1233q6	314	46	through	through	IN
cord-326228-9x1233q6	314	47	impairment	impairment	NN
cord-326228-9x1233q6	314	48	of	of	IN
cord-326228-9x1233q6	314	49	Drp1-triggered	drp1-triggered	JJ
cord-326228-9x1233q6	314	50	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	314	51	fission	fission	NN
cord-326228-9x1233q6	314	52	SARS	SARS	NNP
cord-326228-9x1233q6	314	53	-	-	HYPH
cord-326228-9x1233q6	314	54	coronavirus	coronavirus	NN
cord-326228-9x1233q6	314	55	open	open	JJ
cord-326228-9x1233q6	314	56	reading	reading	NN
cord-326228-9x1233q6	315	1	frame-9b	frame-9b	NNP
cord-326228-9x1233q6	315	2	suppresses	suppress	VBZ
cord-326228-9x1233q6	315	3	innate	innate	JJ
cord-326228-9x1233q6	315	4	immunity	immunity	NN
cord-326228-9x1233q6	315	5	by	by	IN
cord-326228-9x1233q6	315	6	targeting	target	VBG
cord-326228-9x1233q6	315	7	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	315	8	and	and	CC
cord-326228-9x1233q6	315	9	the	the	DT
cord-326228-9x1233q6	315	10	MAVS	MAVS	NNPS
cord-326228-9x1233q6	315	11	/	/	SYM
cord-326228-9x1233q6	315	12	TRAF3	TRAF3	NNP
cord-326228-9x1233q6	315	13	/	/	SYM
cord-326228-9x1233q6	315	14	TRAF6	TRAF6	NNP
cord-326228-9x1233q6	315	15	signalosome	signalosome	NNP
cord-326228-9x1233q6	316	1	The	the	DT
cord-326228-9x1233q6	316	2	essential	essential	JJ
cord-326228-9x1233q6	316	3	role	role	NN
cord-326228-9x1233q6	316	4	of	of	IN
cord-326228-9x1233q6	316	5	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	316	6	dynamics	dynamic	NNS
cord-326228-9x1233q6	316	7	in	in	IN
cord-326228-9x1233q6	316	8	antiviral	antiviral	JJ
cord-326228-9x1233q6	316	9	immunity	immunity	NN
cord-326228-9x1233q6	316	10	Disease	Disease	NNP
cord-326228-9x1233q6	316	11	-	-	HYPH
cord-326228-9x1233q6	316	12	induced	induce	VBN
cord-326228-9x1233q6	316	13	neuroinflammation	neuroinflammation	NN
cord-326228-9x1233q6	316	14	and	and	CC
cord-326228-9x1233q6	316	15	depression	depression	NN
cord-326228-9x1233q6	316	16	Alarmins	Alarmins	NNP
cord-326228-9x1233q6	316	17	and	and	CC
cord-326228-9x1233q6	316	18	central	central	JJ
cord-326228-9x1233q6	316	19	nervous	nervous	JJ
cord-326228-9x1233q6	316	20	system	system	NN
cord-326228-9x1233q6	316	21	inflammation	inflammation	NN
cord-326228-9x1233q6	316	22	in	in	IN
cord-326228-9x1233q6	316	23	HIV	HIV	NNP
cord-326228-9x1233q6	316	24	-	-	HYPH
cord-326228-9x1233q6	316	25	associated	associate	VBN
cord-326228-9x1233q6	316	26	neurological	neurological	JJ
cord-326228-9x1233q6	316	27	disorders	disorder	NNS
cord-326228-9x1233q6	316	28	NLRP3	nlrp3	NN
cord-326228-9x1233q6	316	29	is	be	VBZ
cord-326228-9x1233q6	316	30	activated	activate	VBN
cord-326228-9x1233q6	316	31	in	in	IN
cord-326228-9x1233q6	316	32	Alzheimer	Alzheimer	NNP
cord-326228-9x1233q6	316	33	's	's	POS
cord-326228-9x1233q6	316	34	disease	disease	NN
cord-326228-9x1233q6	316	35	and	and	CC
cord-326228-9x1233q6	316	36	contributes	contribute	VBZ
cord-326228-9x1233q6	316	37	to	to	IN
cord-326228-9x1233q6	316	38	pathology	pathology	NN
cord-326228-9x1233q6	316	39	in	in	IN
cord-326228-9x1233q6	316	40	APP	app	NN
cord-326228-9x1233q6	316	41	/	/	SYM
cord-326228-9x1233q6	316	42	PS1	PS1	NNP
cord-326228-9x1233q6	316	43	mice	mouse	NNS
cord-326228-9x1233q6	317	1	Inflammasome	Inflammasome	NNP
cord-326228-9x1233q6	317	2	inhibition	inhibition	NN
cord-326228-9x1233q6	317	3	prevents	prevent	VBZ
cord-326228-9x1233q6	317	4	a	a	DT
cord-326228-9x1233q6	317	5	-	-	HYPH
cord-326228-9x1233q6	317	6	synuclein	synuclein	NN
cord-326228-9x1233q6	317	7	pathology	pathology	NN
cord-326228-9x1233q6	317	8	and	and	CC
cord-326228-9x1233q6	317	9	dopaminergic	dopaminergic	JJ
cord-326228-9x1233q6	317	10	neurodegeneration	neurodegeneration	NN
cord-326228-9x1233q6	317	11	in	in	IN
cord-326228-9x1233q6	317	12	mice	mouse	NNS
cord-326228-9x1233q6	317	13	Identification	identification	NN
cord-326228-9x1233q6	317	14	and	and	CC
cord-326228-9x1233q6	317	15	characterization	characterization	NN
cord-326228-9x1233q6	317	16	of	of	IN
cord-326228-9x1233q6	317	17	MAVS	MAVS	NNPS
cord-326228-9x1233q6	317	18	,	,	,
cord-326228-9x1233q6	317	19	a	a	DT
cord-326228-9x1233q6	317	20	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	317	21	antiviral	antiviral	JJ
cord-326228-9x1233q6	317	22	signaling	signal	VBG
cord-326228-9x1233q6	317	23	protein	protein	NN
cord-326228-9x1233q6	317	24	that	that	WDT
cord-326228-9x1233q6	317	25	activates	activate	VBZ
cord-326228-9x1233q6	317	26	NF	nf	NN
cord-326228-9x1233q6	317	27	-	-	HYPH
cord-326228-9x1233q6	317	28	jB	jB	NNP
cord-326228-9x1233q6	317	29	and	and	CC
cord-326228-9x1233q6	317	30	IRF3	IRF3	NNP
cord-326228-9x1233q6	318	1	The	the	DT
cord-326228-9x1233q6	318	2	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	318	3	antiviral	antiviral	JJ
cord-326228-9x1233q6	318	4	protein	protein	NN
cord-326228-9x1233q6	318	5	MAVS	MAVS	NNP
cord-326228-9x1233q6	318	6	associates	associate	NNS
cord-326228-9x1233q6	318	7	with	with	IN
cord-326228-9x1233q6	318	8	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	318	9	and	and	CC
cord-326228-9x1233q6	318	10	regulates	regulate	VBZ
cord-326228-9x1233q6	318	11	its	-PRON-	PRP$
cord-326228-9x1233q6	318	12	inflammasome	inflammasome	NN
cord-326228-9x1233q6	318	13	activity	activity	NN
cord-326228-9x1233q6	318	14	Influenza	Influenza	NNP
cord-326228-9x1233q6	318	15	virus	virus	NN
cord-326228-9x1233q6	319	1	PB1-F2	pb1-f2	JJ
cord-326228-9x1233q6	319	2	protein	protein	NN
cord-326228-9x1233q6	319	3	induces	induce	VBZ
cord-326228-9x1233q6	319	4	cell	cell	NN
cord-326228-9x1233q6	319	5	death	death	NN
cord-326228-9x1233q6	319	6	through	through	IN
cord-326228-9x1233q6	320	1	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	320	2	ANT3	ANT3	NNP
cord-326228-9x1233q6	320	3	and	and	CC
cord-326228-9x1233q6	320	4	VDAC1	VDAC1	NNP
cord-326228-9x1233q6	320	5	Hepatitis	Hepatitis	NNP
cord-326228-9x1233q6	320	6	C	C	NNP
cord-326228-9x1233q6	320	7	virus	virus	NN
cord-326228-9x1233q6	320	8	induces	induce	VBZ
cord-326228-9x1233q6	320	9	the	the	DT
cord-326228-9x1233q6	320	10	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	320	11	translocation	translocation	NN
cord-326228-9x1233q6	320	12	of	of	IN
cord-326228-9x1233q6	320	13	parkin	parkin	NN
cord-326228-9x1233q6	320	14	and	and	CC
cord-326228-9x1233q6	320	15	subsequent	subsequent	JJ
cord-326228-9x1233q6	320	16	mitophagy	mitophagy	NN
cord-326228-9x1233q6	320	17	Hepatitis	Hepatitis	NNP
cord-326228-9x1233q6	320	18	B	B	NNP
cord-326228-9x1233q6	320	19	virus	virus	NN
cord-326228-9x1233q6	320	20	disrupts	disrupt	VBZ
cord-326228-9x1233q6	320	21	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	320	22	dynamics	dynamic	NNS
cord-326228-9x1233q6	320	23	:	:	:
cord-326228-9x1233q6	320	24	induces	induce	VBZ
cord-326228-9x1233q6	320	25	fission	fission	NN
cord-326228-9x1233q6	320	26	and	and	CC
cord-326228-9x1233q6	320	27	mitophagy	mitophagy	NN
cord-326228-9x1233q6	320	28	to	to	TO
cord-326228-9x1233q6	320	29	attenuate	attenuate	VB
cord-326228-9x1233q6	320	30	apoptosis	apoptosis	NN
cord-326228-9x1233q6	320	31	Response	response	NN
cord-326228-9x1233q6	320	32	of	of	IN
cord-326228-9x1233q6	320	33	host	host	NN
cord-326228-9x1233q6	320	34	inflammasomes	inflammasome	NNS
cord-326228-9x1233q6	320	35	to	to	IN
cord-326228-9x1233q6	320	36	viral	viral	JJ
cord-326228-9x1233q6	320	37	infection	infection	NN
cord-326228-9x1233q6	321	1	Mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	321	2	protein	protein	NN
cord-326228-9x1233q6	321	3	mitofusin	mitofusin	NNP
cord-326228-9x1233q6	321	4	2	2	CD
cord-326228-9x1233q6	321	5	is	be	VBZ
cord-326228-9x1233q6	321	6	required	require	VBN
cord-326228-9x1233q6	321	7	for	for	IN
cord-326228-9x1233q6	321	8	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	321	9	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	321	10	activation	activation	NN
cord-326228-9x1233q6	321	11	after	after	IN
cord-326228-9x1233q6	321	12	RNA	RNA	NNP
cord-326228-9x1233q6	321	13	virus	virus	NN
cord-326228-9x1233q6	321	14	infection	infection	NN
cord-326228-9x1233q6	321	15	RNA	RNA	NNP
cord-326228-9x1233q6	321	16	viruses	virus	NNS
cord-326228-9x1233q6	321	17	promote	promote	VBP
cord-326228-9x1233q6	321	18	activation	activation	NN
cord-326228-9x1233q6	321	19	of	of	IN
cord-326228-9x1233q6	321	20	the	the	DT
cord-326228-9x1233q6	321	21	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	321	22	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	321	23	through	through	IN
cord-326228-9x1233q6	321	24	a	a	DT
cord-326228-9x1233q6	321	25	RIP1-RIP3-DRP1	rip1-rip3-drp1	NN
cord-326228-9x1233q6	321	26	signaling	signal	VBG
cord-326228-9x1233q6	321	27	pathway	pathway	NN
cord-326228-9x1233q6	322	1	Parkin	parkin	NN
cord-326228-9x1233q6	322	2	impairs	impair	VBZ
cord-326228-9x1233q6	322	3	antiviral	antiviral	JJ
cord-326228-9x1233q6	322	4	immunity	immunity	NN
cord-326228-9x1233q6	322	5	by	by	IN
cord-326228-9x1233q6	322	6	suppressing	suppress	VBG
cord-326228-9x1233q6	322	7	the	the	DT
cord-326228-9x1233q6	322	8	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	322	9	reactive	reactive	JJ
cord-326228-9x1233q6	322	10	oxygen	oxygen	NN
cord-326228-9x1233q6	322	11	species	specie	NNS
cord-326228-9x1233q6	322	12	-	-	:
cord-326228-9x1233q6	322	13	Nlrp3	nlrp3	JJ
cord-326228-9x1233q6	322	14	axis	axis	NN
cord-326228-9x1233q6	322	15	and	and	CC
cord-326228-9x1233q6	323	1	antiviral	antiviral	JJ
cord-326228-9x1233q6	323	2	inflammation	inflammation	NN
cord-326228-9x1233q6	323	3	HBV	HBV	NNP
cord-326228-9x1233q6	323	4	inhibits	inhibit	VBZ
cord-326228-9x1233q6	324	1	LPS	LPS	NNP
cord-326228-9x1233q6	324	2	-	-	HYPH
cord-326228-9x1233q6	324	3	induced	induce	VBN
cord-326228-9x1233q6	324	4	NLRP3	nlrp3	NN
cord-326228-9x1233q6	324	5	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	324	6	activation	activation	NN
cord-326228-9x1233q6	324	7	and	and	CC
cord-326228-9x1233q6	324	8	IL-1b	IL-1b	NNP
cord-326228-9x1233q6	324	9	production	production	NN
cord-326228-9x1233q6	324	10	via	via	IN
cord-326228-9x1233q6	324	11	suppressing	suppress	VBG
cord-326228-9x1233q6	324	12	the	the	DT
cord-326228-9x1233q6	324	13	NF	nf	NN
cord-326228-9x1233q6	324	14	-	-	HYPH
cord-326228-9x1233q6	324	15	jB	jB	NNP
cord-326228-9x1233q6	324	16	pathway	pathway	NN
cord-326228-9x1233q6	324	17	and	and	CC
cord-326228-9x1233q6	324	18	ROS	ROS	NNP
cord-326228-9x1233q6	324	19	production	production	NN
cord-326228-9x1233q6	324	20	PB1-F2	PB1-F2	NNP
cord-326228-9x1233q6	324	21	Peptide	Peptide	NNP
cord-326228-9x1233q6	324	22	derived	derive	VBN
cord-326228-9x1233q6	324	23	from	from	IN
cord-326228-9x1233q6	324	24	avian	avian	JJ
cord-326228-9x1233q6	324	25	influenza	influenza	NN
cord-326228-9x1233q6	324	26	A	a	DT
cord-326228-9x1233q6	324	27	virus	virus	NN
cord-326228-9x1233q6	324	28	H7N9	H7N9	NNP
cord-326228-9x1233q6	324	29	induces	induce	VBZ
cord-326228-9x1233q6	324	30	inflammation	inflammation	NN
cord-326228-9x1233q6	324	31	via	via	IN
cord-326228-9x1233q6	324	32	activation	activation	NN
cord-326228-9x1233q6	324	33	of	of	IN
cord-326228-9x1233q6	324	34	the	the	DT
cord-326228-9x1233q6	324	35	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	324	36	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	324	37	Caspase-8	Caspase-8	NNP
cord-326228-9x1233q6	324	38	scaffolding	scaffolding	NN
cord-326228-9x1233q6	324	39	function	function	NN
cord-326228-9x1233q6	324	40	and	and	CC
cord-326228-9x1233q6	324	41	MLKL	MLKL	NNP
cord-326228-9x1233q6	324	42	regulate	regulate	VBP
cord-326228-9x1233q6	324	43	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	324	44	inflammasome	inflammasome	NN
cord-326228-9x1233q6	324	45	activation	activation	NN
cord-326228-9x1233q6	324	46	downstream	downstream	RB
cord-326228-9x1233q6	324	47	of	of	IN
cord-326228-9x1233q6	324	48	TLR3	TLR3	NNP
cord-326228-9x1233q6	324	49	Mitochondria	Mitochondria	NNP
cord-326228-9x1233q6	324	50	:	:	:
cord-326228-9x1233q6	324	51	a	a	DT
cord-326228-9x1233q6	324	52	target	target	NN
cord-326228-9x1233q6	324	53	for	for	IN
cord-326228-9x1233q6	324	54	bacteria	bacteria	NNS
cord-326228-9x1233q6	324	55	Listeria	Listeria	NNP
cord-326228-9x1233q6	324	56	monocytogenes	monocytogene	NNS
cord-326228-9x1233q6	324	57	is	be	VBZ
cord-326228-9x1233q6	324	58	sensed	sense	VBN
cord-326228-9x1233q6	324	59	by	by	IN
cord-326228-9x1233q6	324	60	the	the	DT
cord-326228-9x1233q6	324	61	NLRP3	nlrp3	NN
cord-326228-9x1233q6	324	62	and	and	CC
cord-326228-9x1233q6	324	63	AIM2	AIM2	NNP
cord-326228-9x1233q6	324	64	inflammasome	inflammasome	NN
cord-326228-9x1233q6	324	65	Listeria	Listeria	NNP
cord-326228-9x1233q6	324	66	monocytogenes	monocytogene	NNS
cord-326228-9x1233q6	324	67	and	and	CC
cord-326228-9x1233q6	324	68	the	the	DT
cord-326228-9x1233q6	324	69	inflammasome	inflammasome	NN
cord-326228-9x1233q6	324	70	:	:	:
cord-326228-9x1233q6	324	71	from	from	IN
cord-326228-9x1233q6	324	72	cytosolic	cytosolic	JJ
cord-326228-9x1233q6	324	73	bacteriolysis	bacteriolysis	NN
cord-326228-9x1233q6	324	74	to	to	IN
cord-326228-9x1233q6	324	75	tumor	tumor	NN
cord-326228-9x1233q6	324	76	immunotherapy	immunotherapy	NN
cord-326228-9x1233q6	324	77	Atypical	atypical	JJ
cord-326228-9x1233q6	324	78	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	324	79	fission	fission	NN
cord-326228-9x1233q6	324	80	upon	upon	IN
cord-326228-9x1233q6	324	81	bacterial	bacterial	JJ
cord-326228-9x1233q6	324	82	infection	infection	NN
cord-326228-9x1233q6	324	83	Mitochondria	mitochondria	NN
cord-326228-9x1233q6	324	84	-	-	HYPH
cord-326228-9x1233q6	324	85	associated	associate	VBN
cord-326228-9x1233q6	324	86	membranes	membrane	NNS
cord-326228-9x1233q6	324	87	(	(	-LRB-
cord-326228-9x1233q6	324	88	MAMs	mam	NNS
cord-326228-9x1233q6	324	89	)	)	-RRB-
cord-326228-9x1233q6	324	90	and	and	CC
cord-326228-9x1233q6	325	1	inflammation	inflammation	NN
cord-326228-9x1233q6	325	2	Legionella	Legionella	NNP
cord-326228-9x1233q6	325	3	pneumophila	pneumophila	NN
cord-326228-9x1233q6	325	4	modulates	modulate	VBZ
cord-326228-9x1233q6	325	5	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	325	6	dynamics	dynamic	NNS
cord-326228-9x1233q6	325	7	to	to	TO
cord-326228-9x1233q6	325	8	trigger	trigger	VB
cord-326228-9x1233q6	325	9	metabolic	metabolic	JJ
cord-326228-9x1233q6	325	10	repurposing	repurposing	NN
cord-326228-9x1233q6	325	11	of	of	IN
cord-326228-9x1233q6	325	12	infected	infected	JJ
cord-326228-9x1233q6	325	13	macrophages	macrophage	NNS
cord-326228-9x1233q6	326	1	Caspase-11	Caspase-11	NNP
cord-326228-9x1233q6	326	2	stimulates	stimulate	VBZ
cord-326228-9x1233q6	326	3	rapid	rapid	JJ
cord-326228-9x1233q6	326	4	flagellin	flagellin	JJ
cord-326228-9x1233q6	326	5	-	-	HYPH
cord-326228-9x1233q6	326	6	independent	independent	JJ
cord-326228-9x1233q6	326	7	pyroptosis	pyroptosis	NN
cord-326228-9x1233q6	326	8	in	in	IN
cord-326228-9x1233q6	326	9	response	response	NN
cord-326228-9x1233q6	326	10	to	to	IN
cord-326228-9x1233q6	326	11	Legionella	Legionella	NNP
cord-326228-9x1233q6	326	12	pneumophila	pneumophila	NN
cord-326228-9x1233q6	326	13	AIM2	AIM2	NNP
cord-326228-9x1233q6	326	14	engages	engage	VBZ
cord-326228-9x1233q6	326	15	active	active	JJ
cord-326228-9x1233q6	326	16	but	but	CC
cord-326228-9x1233q6	326	17	unprocessed	unprocessed	JJ
cord-326228-9x1233q6	326	18	caspase-1	caspase-1	NNP
cord-326228-9x1233q6	326	19	to	to	TO
cord-326228-9x1233q6	326	20	induce	induce	VB
cord-326228-9x1233q6	326	21	noncanonical	noncanonical	JJ
cord-326228-9x1233q6	326	22	activation	activation	NN
cord-326228-9x1233q6	326	23	of	of	IN
cord-326228-9x1233q6	326	24	the	the	DT
cord-326228-9x1233q6	326	25	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	326	26	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	326	27	Structure	Structure	NNP
cord-326228-9x1233q6	326	28	and	and	CC
cord-326228-9x1233q6	326	29	function	function	NN
cord-326228-9x1233q6	326	30	of	of	IN
cord-326228-9x1233q6	326	31	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	326	32	supercomplexes	supercomplexes	NNP
cord-326228-9x1233q6	326	33	Mitochondrial	Mitochondrial	NNP
cord-326228-9x1233q6	326	34	control	control	NN
cord-326228-9x1233q6	326	35	of	of	IN
cord-326228-9x1233q6	326	36	immunity	immunity	NN
cord-326228-9x1233q6	326	37	:	:	:
cord-326228-9x1233q6	326	38	beyond	beyond	IN
cord-326228-9x1233q6	326	39	ATP	ATP	NNP
cord-326228-9x1233q6	326	40	Metabolic	Metabolic	NNP
cord-326228-9x1233q6	326	41	reprogramming	reprogramming	NN
cord-326228-9x1233q6	326	42	in	in	IN
cord-326228-9x1233q6	326	43	macrophages	macrophage	NNS
cord-326228-9x1233q6	326	44	and	and	CC
cord-326228-9x1233q6	326	45	dendritic	dendritic	JJ
cord-326228-9x1233q6	326	46	cells	cell	NNS
cord-326228-9x1233q6	326	47	in	in	IN
cord-326228-9x1233q6	326	48	innate	innate	JJ
cord-326228-9x1233q6	326	49	immunity	immunity	NN
cord-326228-9x1233q6	326	50	The	the	DT
cord-326228-9x1233q6	326	51	Warburg	Warburg	NNP
cord-326228-9x1233q6	326	52	effect	effect	NN
cord-326228-9x1233q6	326	53	then	then	RB
cord-326228-9x1233q6	326	54	and	and	CC
cord-326228-9x1233q6	326	55	now	now	RB
cord-326228-9x1233q6	326	56	:	:	:
cord-326228-9x1233q6	326	57	from	from	IN
cord-326228-9x1233q6	326	58	cancer	cancer	NN
cord-326228-9x1233q6	326	59	to	to	IN
cord-326228-9x1233q6	327	1	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	327	2	diseases	disease	NNS
cord-326228-9x1233q6	327	3	Substrate	Substrate	NNP
cord-326228-9x1233q6	327	4	fate	fate	NN
cord-326228-9x1233q6	327	5	in	in	IN
cord-326228-9x1233q6	327	6	activated	activate	VBN
cord-326228-9x1233q6	327	7	macrophages	macrophage	NNS
cord-326228-9x1233q6	327	8	:	:	:
cord-326228-9x1233q6	327	9	a	a	DT
cord-326228-9x1233q6	327	10	comparison	comparison	NN
cord-326228-9x1233q6	327	11	between	between	IN
cord-326228-9x1233q6	327	12	innate	innate	JJ
cord-326228-9x1233q6	327	13	,	,	,
cord-326228-9x1233q6	327	14	classic	classic	JJ
cord-326228-9x1233q6	327	15	,	,	,
cord-326228-9x1233q6	327	16	and	and	CC
cord-326228-9x1233q6	327	17	alternative	alternative	JJ
cord-326228-9x1233q6	327	18	activation	activation	NN
cord-326228-9x1233q6	327	19	Metabolism	metabolism	NN
cord-326228-9x1233q6	327	20	of	of	IN
cord-326228-9x1233q6	327	21	glucose	glucose	NN
cord-326228-9x1233q6	327	22	,	,	,
cord-326228-9x1233q6	327	23	glutamine	glutamine	NN
cord-326228-9x1233q6	327	24	,	,	,
cord-326228-9x1233q6	327	25	long	long	JJ
cord-326228-9x1233q6	327	26	-	-	HYPH
cord-326228-9x1233q6	327	27	chain	chain	NN
cord-326228-9x1233q6	327	28	fatty	fatty	JJ
cord-326228-9x1233q6	327	29	acids	acid	NNS
cord-326228-9x1233q6	327	30	and	and	CC
cord-326228-9x1233q6	327	31	ketone	ketone	NN
cord-326228-9x1233q6	327	32	bodies	body	NNS
cord-326228-9x1233q6	327	33	by	by	IN
cord-326228-9x1233q6	327	34	murine	murine	JJ
cord-326228-9x1233q6	327	35	macrophages	macrophage	NNS
cord-326228-9x1233q6	328	1	mTORC1-induced	mtorc1-induce	VBN
cord-326228-9x1233q6	328	2	HK1-dependent	HK1-dependent	NNP
cord-326228-9x1233q6	328	3	glycolysis	glycolysis	NN
cord-326228-9x1233q6	328	4	regulates	regulate	VBZ
cord-326228-9x1233q6	328	5	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	328	6	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	328	7	activation	activation	NN
cord-326228-9x1233q6	329	1	The	the	DT
cord-326228-9x1233q6	329	2	NLRP3	nlrp3	NN
cord-326228-9x1233q6	329	3	inflammasome	inflammasome	NN
cord-326228-9x1233q6	329	4	modulates	modulate	VBZ
cord-326228-9x1233q6	329	5	glycolysis	glycolysis	NN
cord-326228-9x1233q6	329	6	by	by	IN
cord-326228-9x1233q6	329	7	increasing	increase	VBG
cord-326228-9x1233q6	329	8	PFKFB3	pfkfb3	NN
cord-326228-9x1233q6	329	9	in	in	IN
cord-326228-9x1233q6	329	10	an	an	DT
cord-326228-9x1233q6	329	11	IL-1b	IL-1b	VBN
cord-326228-9x1233q6	329	12	-	-	HYPH
cord-326228-9x1233q6	329	13	dependent	dependent	JJ
cord-326228-9x1233q6	329	14	manner	manner	NN
cord-326228-9x1233q6	329	15	in	in	IN
cord-326228-9x1233q6	329	16	macrophages	macrophage	NNS
cord-326228-9x1233q6	330	1	How	how	WRB
cord-326228-9x1233q6	330	2	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	330	3	produce	produce	VBP
cord-326228-9x1233q6	330	4	reactive	reactive	JJ
cord-326228-9x1233q6	330	5	oxygen	oxygen	NN
cord-326228-9x1233q6	330	6	species	specie	NNS
cord-326228-9x1233q6	330	7	Superoxide	superoxide	NN
cord-326228-9x1233q6	330	8	generation	generation	NN
cord-326228-9x1233q6	330	9	by	by	IN
cord-326228-9x1233q6	330	10	complex	complex	JJ
cord-326228-9x1233q6	330	11	III	iii	CD
cord-326228-9x1233q6	330	12	:	:	:
cord-326228-9x1233q6	330	13	from	from	IN
cord-326228-9x1233q6	330	14	mechanistic	mechanistic	JJ
cord-326228-9x1233q6	330	15	rationales	rationale	NNS
cord-326228-9x1233q6	330	16	to	to	IN
cord-326228-9x1233q6	330	17	functional	functional	JJ
cord-326228-9x1233q6	330	18	consequences	consequence	NNS
cord-326228-9x1233q6	331	1	Mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	331	2	reactive	reactive	JJ
cord-326228-9x1233q6	331	3	oxygen	oxygen	NN
cord-326228-9x1233q6	331	4	species	specie	NNS
cord-326228-9x1233q6	331	5	induces	induce	VBZ
cord-326228-9x1233q6	331	6	NLRP3-dependent	NLRP3-dependent	NNP
cord-326228-9x1233q6	331	7	lysosomal	lysosomal	JJ
cord-326228-9x1233q6	331	8	damage	damage	NN
cord-326228-9x1233q6	331	9	and	and	CC
cord-326228-9x1233q6	331	10	inflammasome	inflammasome	NN
cord-326228-9x1233q6	331	11	activation	activation	NN
cord-326228-9x1233q6	331	12	A	a	DT
cord-326228-9x1233q6	331	13	role	role	NN
cord-326228-9x1233q6	331	14	for	for	IN
cord-326228-9x1233q6	331	15	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	331	16	in	in	IN
cord-326228-9x1233q6	331	17	NLRP3	nlrp3	NN
cord-326228-9x1233q6	332	1	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	332	2	activation	activation	NN
cord-326228-9x1233q6	332	3	Downregulation	Downregulation	NNP
cord-326228-9x1233q6	332	4	of	of	IN
cord-326228-9x1233q6	332	5	cytoplasmic	cytoplasmic	JJ
cord-326228-9x1233q6	332	6	DNases	DNases	NNPS
cord-326228-9x1233q6	332	7	is	be	VBZ
cord-326228-9x1233q6	332	8	implicated	implicate	VBN
cord-326228-9x1233q6	332	9	in	in	IN
cord-326228-9x1233q6	332	10	cytoplasmic	cytoplasmic	JJ
cord-326228-9x1233q6	332	11	DNA	dna	NN
cord-326228-9x1233q6	332	12	accumulation	accumulation	NN
cord-326228-9x1233q6	332	13	and	and	CC
cord-326228-9x1233q6	332	14	SASP	SASP	NNP
cord-326228-9x1233q6	332	15	in	in	IN
cord-326228-9x1233q6	332	16	senescent	senescent	JJ
cord-326228-9x1233q6	332	17	cells	cell	NNS
cord-326228-9x1233q6	333	1	Tiered	tiered	JJ
cord-326228-9x1233q6	333	2	DNA	dna	NN
cord-326228-9x1233q6	333	3	sensors	sensor	NNS
cord-326228-9x1233q6	333	4	for	for	IN
cord-326228-9x1233q6	333	5	escalating	escalate	VBG
cord-326228-9x1233q6	333	6	responses	response	NNS
cord-326228-9x1233q6	333	7	Autophagy	Autophagy	NNP
cord-326228-9x1233q6	333	8	proteins	protein	NNS
cord-326228-9x1233q6	333	9	regulate	regulate	VBP
cord-326228-9x1233q6	333	10	innate	innate	JJ
cord-326228-9x1233q6	333	11	immune	immune	JJ
cord-326228-9x1233q6	333	12	responses	response	NNS
cord-326228-9x1233q6	333	13	by	by	IN
cord-326228-9x1233q6	333	14	inhibiting	inhibit	VBG
cord-326228-9x1233q6	333	15	the	the	DT
cord-326228-9x1233q6	333	16	release	release	NN
cord-326228-9x1233q6	333	17	of	of	IN
cord-326228-9x1233q6	333	18	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	333	19	DNA	dna	NN
cord-326228-9x1233q6	333	20	mediated	mediate	VBN
cord-326228-9x1233q6	333	21	by	by	IN
cord-326228-9x1233q6	333	22	the	the	DT
cord-326228-9x1233q6	333	23	NALP3	NALP3	NNP
cord-326228-9x1233q6	333	24	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	333	25	NF	NF	NNP
cord-326228-9x1233q6	334	1	-jB	-jB	:
cord-326228-9x1233q6	334	2	Restricts	restrict	VBZ
cord-326228-9x1233q6	334	3	inflammasome	inflammasome	NN
cord-326228-9x1233q6	334	4	activation	activation	NN
cord-326228-9x1233q6	334	5	via	via	IN
cord-326228-9x1233q6	334	6	elimination	elimination	NN
cord-326228-9x1233q6	334	7	of	of	IN
cord-326228-9x1233q6	334	8	damaged	damaged	JJ
cord-326228-9x1233q6	334	9	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	334	10	Fatty	fatty	JJ
cord-326228-9x1233q6	334	11	acid	acid	NN
cord-326228-9x1233q6	334	12	activates	activate	VBZ
cord-326228-9x1233q6	334	13	NLRP3	nlrp3	XX
cord-326228-9x1233q6	334	14	inflammasomes	inflammasome	NNS
cord-326228-9x1233q6	334	15	in	in	IN
cord-326228-9x1233q6	334	16	mouse	mouse	NN
cord-326228-9x1233q6	334	17	Kupffer	Kupffer	NNP
cord-326228-9x1233q6	334	18	cells	cell	NNS
cord-326228-9x1233q6	334	19	through	through	IN
cord-326228-9x1233q6	334	20	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	334	21	DNA	dna	NN
cord-326228-9x1233q6	334	22	release	release	NN
cord-326228-9x1233q6	335	1	New	new	JJ
cord-326228-9x1233q6	335	2	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	335	3	DNA	dna	NN
cord-326228-9x1233q6	335	4	synthesis	synthesis	NN
cord-326228-9x1233q6	335	5	enables	enable	VBZ
cord-326228-9x1233q6	335	6	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	335	7	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	335	8	activation	activation	NN
cord-326228-9x1233q6	336	1	The	the	DT
cord-326228-9x1233q6	336	2	DNA	dna	NN
cord-326228-9x1233q6	336	3	inflammasome	inflammasome	NN
cord-326228-9x1233q6	336	4	in	in	IN
cord-326228-9x1233q6	336	5	human	human	JJ
cord-326228-9x1233q6	336	6	myeloid	myeloid	NN
cord-326228-9x1233q6	336	7	cells	cell	NNS
cord-326228-9x1233q6	336	8	is	be	VBZ
cord-326228-9x1233q6	336	9	initiated	initiate	VBN
cord-326228-9x1233q6	336	10	by	by	IN
cord-326228-9x1233q6	336	11	a	a	DT
cord-326228-9x1233q6	336	12	STING	sting	NN
cord-326228-9x1233q6	336	13	-	-	HYPH
cord-326228-9x1233q6	336	14	Cell	cell	NN
cord-326228-9x1233q6	336	15	death	death	NN
cord-326228-9x1233q6	336	16	program	program	NN
cord-326228-9x1233q6	336	17	upstream	upstream	RB
cord-326228-9x1233q6	336	18	of	of	IN
cord-326228-9x1233q6	336	19	NLRP3	nlrp3	NN
cord-326228-9x1233q6	337	1	Simultaneous	simultaneous	JJ
cord-326228-9x1233q6	337	2	monitoring	monitoring	NN
cord-326228-9x1233q6	337	3	of	of	IN
cord-326228-9x1233q6	337	4	ionophoreand	ionophoreand	JJ
cord-326228-9x1233q6	337	5	inhibitor	inhibitor	NN
cord-326228-9x1233q6	337	6	-	-	HYPH
cord-326228-9x1233q6	337	7	mediated	mediate	VBN
cord-326228-9x1233q6	337	8	plasma	plasma	NN
cord-326228-9x1233q6	337	9	and	and	CC
cord-326228-9x1233q6	337	10	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	337	11	membrane	membrane	NN
cord-326228-9x1233q6	337	12	potential	potential	JJ
cord-326228-9x1233q6	337	13	changes	change	NNS
cord-326228-9x1233q6	337	14	in	in	IN
cord-326228-9x1233q6	337	15	cultured	cultured	JJ
cord-326228-9x1233q6	337	16	neurons	neuron	NNS
cord-326228-9x1233q6	338	1	Inflammasomeindependent	inflammasomeindependent	JJ
cord-326228-9x1233q6	338	2	role	role	NN
cord-326228-9x1233q6	338	3	of	of	IN
cord-326228-9x1233q6	338	4	NLRP3	nlrp3	NN
cord-326228-9x1233q6	338	5	mediates	mediate	VBZ
cord-326228-9x1233q6	338	6	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	338	7	regulation	regulation	NN
cord-326228-9x1233q6	338	8	in	in	IN
cord-326228-9x1233q6	338	9	renal	renal	JJ
cord-326228-9x1233q6	338	10	injury	injury	NN
cord-326228-9x1233q6	338	11	Inflammasome	Inflammasome	NNP
cord-326228-9x1233q6	338	12	activation	activation	NN
cord-326228-9x1233q6	338	13	leads	lead	VBZ
cord-326228-9x1233q6	338	14	to	to	IN
cord-326228-9x1233q6	338	15	Caspase-1-dependent	Caspase-1-dependent	NNP
cord-326228-9x1233q6	338	16	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	338	17	damage	damage	NN
cord-326228-9x1233q6	338	18	and	and	CC
cord-326228-9x1233q6	338	19	block	block	NN
cord-326228-9x1233q6	338	20	of	of	IN
cord-326228-9x1233q6	338	21	mitophagy	mitophagy	NNP
cord-326228-9x1233q6	338	22	Cell	Cell	NNP
cord-326228-9x1233q6	338	23	survival	survival	NN
cord-326228-9x1233q6	338	24	and	and	CC
cord-326228-9x1233q6	338	25	cytokine	cytokine	NN
cord-326228-9x1233q6	338	26	release	release	NN
cord-326228-9x1233q6	338	27	after	after	IN
cord-326228-9x1233q6	338	28	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	338	29	activation	activation	NN
cord-326228-9x1233q6	338	30	is	be	VBZ
cord-326228-9x1233q6	338	31	regulated	regulate	VBN
cord-326228-9x1233q6	338	32	by	by	IN
cord-326228-9x1233q6	338	33	the	the	DT
cord-326228-9x1233q6	338	34	Toll	Toll	NNP
cord-326228-9x1233q6	338	35	-	-	HYPH
cord-326228-9x1233q6	338	36	IL-1R	IL-1R	NNP
cord-326228-9x1233q6	338	37	protein	protein	NN
cord-326228-9x1233q6	338	38	SARM	SARM	NNP
cord-326228-9x1233q6	339	1	The	the	DT
cord-326228-9x1233q6	339	2	cGAS	cgas	JJ
cord-326228-9x1233q6	339	3	-	-	HYPH
cord-326228-9x1233q6	339	4	cGAMP	cgamp	JJ
cord-326228-9x1233q6	339	5	-	-	HYPH
cord-326228-9x1233q6	339	6	STING	sting	NN
cord-326228-9x1233q6	339	7	pathway	pathway	NN
cord-326228-9x1233q6	339	8	connects	connect	VBZ
cord-326228-9x1233q6	339	9	DNA	dna	NN
cord-326228-9x1233q6	339	10	damage	damage	NN
cord-326228-9x1233q6	339	11	to	to	IN
cord-326228-9x1233q6	339	12	inflammation	inflammation	NN
cord-326228-9x1233q6	339	13	,	,	,
cord-326228-9x1233q6	339	14	senescence	senescence	NN
cord-326228-9x1233q6	339	15	,	,	,
cord-326228-9x1233q6	339	16	and	and	CC
cord-326228-9x1233q6	339	17	cancer	cancer	NN
cord-326228-9x1233q6	339	18	Regulation	regulation	NN
cord-326228-9x1233q6	339	19	and	and	CC
cord-326228-9x1233q6	339	20	function	function	NN
cord-326228-9x1233q6	339	21	of	of	IN
cord-326228-9x1233q6	339	22	the	the	DT
cord-326228-9x1233q6	339	23	cGAS	cgas	JJ
cord-326228-9x1233q6	339	24	-	-	HYPH
cord-326228-9x1233q6	339	25	STING	sting	NN
cord-326228-9x1233q6	339	26	pathway	pathway	NN
cord-326228-9x1233q6	339	27	of	of	IN
cord-326228-9x1233q6	339	28	cytosolic	cytosolic	JJ
cord-326228-9x1233q6	339	29	DNA	dna	NN
cord-326228-9x1233q6	339	30	sensing	sensing	NN
cord-326228-9x1233q6	339	31	BAK/	BAK/	NNP
cord-326228-9x1233q6	339	32	BAX	BAX	NNP
cord-326228-9x1233q6	339	33	macropores	macropore	NNS
cord-326228-9x1233q6	339	34	facilitate	facilitate	VBP
cord-326228-9x1233q6	339	35	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	339	36	herniation	herniation	NN
cord-326228-9x1233q6	339	37	and	and	CC
cord-326228-9x1233q6	339	38	mtDNA	mtdna	NN
cord-326228-9x1233q6	339	39	efflux	efflux	NN
cord-326228-9x1233q6	339	40	during	during	IN
cord-326228-9x1233q6	339	41	apoptosis	apoptosis	NN
cord-326228-9x1233q6	339	42	Mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	339	43	DNA	dna	NN
cord-326228-9x1233q6	339	44	stress	stress	NN
cord-326228-9x1233q6	339	45	primes	prime	VBZ
cord-326228-9x1233q6	339	46	the	the	DT
cord-326228-9x1233q6	339	47	antiviral	antiviral	JJ
cord-326228-9x1233q6	339	48	innate	innate	JJ
cord-326228-9x1233q6	339	49	immune	immune	JJ
cord-326228-9x1233q6	339	50	response	response	NN
cord-326228-9x1233q6	340	1	Interleukin-1b	Interleukin-1b	NNP
cord-326228-9x1233q6	340	2	induces	induce	VBZ
cord-326228-9x1233q6	340	3	mtDNA	mtDNA	NNP
cord-326228-9x1233q6	340	4	release	release	NN
cord-326228-9x1233q6	340	5	to	to	TO
cord-326228-9x1233q6	340	6	activate	activate	VB
cord-326228-9x1233q6	340	7	innate	innate	JJ
cord-326228-9x1233q6	340	8	immune	immune	JJ
cord-326228-9x1233q6	340	9	signaling	signaling	NN
cord-326228-9x1233q6	340	10	via	via	IN
cord-326228-9x1233q6	341	1	cGAS	cgas	JJ
cord-326228-9x1233q6	341	2	-	-	HYPH
cord-326228-9x1233q6	341	3	STING	sting	NN
cord-326228-9x1233q6	341	4	Gasdermin	Gasdermin	NNP
cord-326228-9x1233q6	341	5	D	D	NNP
cord-326228-9x1233q6	341	6	restrains	restrain	VBZ
cord-326228-9x1233q6	341	7	type	type	NN
cord-326228-9x1233q6	341	8	I	-PRON-	PRP
cord-326228-9x1233q6	341	9	interferon	interferon	VBD
cord-326228-9x1233q6	341	10	response	response	NN
cord-326228-9x1233q6	341	11	to	to	IN
cord-326228-9x1233q6	341	12	cytosolic	cytosolic	JJ
cord-326228-9x1233q6	341	13	DNA	dna	NN
cord-326228-9x1233q6	341	14	by	by	IN
cord-326228-9x1233q6	341	15	disrupting	disrupt	VBG
cord-326228-9x1233q6	341	16	ionic	ionic	JJ
cord-326228-9x1233q6	341	17	homeostasis	homeostasis	NN
cord-326228-9x1233q6	341	18	Parkin	Parkin	NNP
cord-326228-9x1233q6	341	19	and	and	CC
cord-326228-9x1233q6	341	20	PINK1	PINK1	NNP
cord-326228-9x1233q6	341	21	mitigate	mitigate	VB
cord-326228-9x1233q6	341	22	STING	sting	NN
cord-326228-9x1233q6	341	23	-	-	HYPH
cord-326228-9x1233q6	341	24	induced	induce	VBN
cord-326228-9x1233q6	341	25	inflammation	inflammation	NN
cord-326228-9x1233q6	342	1	A	a	DT
cord-326228-9x1233q6	342	2	noncanonical	noncanonical	JJ
cord-326228-9x1233q6	342	3	function	function	NN
cord-326228-9x1233q6	342	4	of	of	IN
cord-326228-9x1233q6	342	5	cGAMP	cGAMP	NNP
cord-326228-9x1233q6	342	6	in	in	IN
cord-326228-9x1233q6	342	7	inflammasome	inflammasome	NN
cord-326228-9x1233q6	342	8	priming	priming	NN
cord-326228-9x1233q6	342	9	and	and	CC
cord-326228-9x1233q6	342	10	activation	activation	NN
cord-326228-9x1233q6	342	11	Inflammasome	Inflammasome	NNP
cord-326228-9x1233q6	342	12	activation	activation	NN
cord-326228-9x1233q6	342	13	triggers	trigger	VBZ
cord-326228-9x1233q6	342	14	caspase-1-mediated	caspase-1-mediated	JJ
cord-326228-9x1233q6	342	15	cleavage	cleavage	NN
cord-326228-9x1233q6	342	16	of	of	IN
cord-326228-9x1233q6	342	17	cGAS	cgas	NN
cord-326228-9x1233q6	342	18	to	to	TO
cord-326228-9x1233q6	342	19	regulate	regulate	VB
cord-326228-9x1233q6	342	20	responses	response	NNS
cord-326228-9x1233q6	342	21	to	to	IN
cord-326228-9x1233q6	342	22	DNA	dna	NN
cord-326228-9x1233q6	342	23	virus	virus	NN
cord-326228-9x1233q6	342	24	infection	infection	NN
cord-326228-9x1233q6	342	25	CpG	CpG	NNP
cord-326228-9x1233q6	342	26	motifs	motif	NNS
cord-326228-9x1233q6	342	27	in	in	IN
cord-326228-9x1233q6	342	28	bacterial	bacterial	JJ
cord-326228-9x1233q6	342	29	DNA	dna	NN
cord-326228-9x1233q6	342	30	trigger	trigger	NN
cord-326228-9x1233q6	342	31	direct	direct	JJ
cord-326228-9x1233q6	342	32	B	b	NN
cord-326228-9x1233q6	342	33	-	-	HYPH
cord-326228-9x1233q6	342	34	cell	cell	NN
cord-326228-9x1233q6	342	35	activation	activation	NN
cord-326228-9x1233q6	342	36	Tolllike	Tolllike	NNP
cord-326228-9x1233q6	342	37	receptor	receptor	NN
cord-326228-9x1233q6	342	38	9-mediated	9-mediated	CD
cord-326228-9x1233q6	342	39	recognition	recognition	NN
cord-326228-9x1233q6	342	40	of	of	IN
cord-326228-9x1233q6	342	41	Herpes	Herpes	NNP
cord-326228-9x1233q6	342	42	simplex	simplex	NNP
cord-326228-9x1233q6	342	43	virus-2	virus-2	NNP
cord-326228-9x1233q6	342	44	by	by	IN
cord-326228-9x1233q6	342	45	plasmacytoid	plasmacytoid	NNP
cord-326228-9x1233q6	342	46	dendritic	dendritic	NNP
cord-326228-9x1233q6	342	47	cells	cell	VBZ
cord-326228-9x1233q6	342	48	Expression	expression	NN
cord-326228-9x1233q6	342	49	of	of	IN
cord-326228-9x1233q6	342	50	toll	toll	NN
cord-326228-9x1233q6	342	51	-	-	HYPH
cord-326228-9x1233q6	342	52	like	like	JJ
cord-326228-9x1233q6	342	53	receptor	receptor	NN
cord-326228-9x1233q6	342	54	9	9	CD
cord-326228-9x1233q6	342	55	in	in	IN
cord-326228-9x1233q6	342	56	mouse	mouse	NN
cord-326228-9x1233q6	342	57	and	and	CC
cord-326228-9x1233q6	342	58	human	human	JJ
cord-326228-9x1233q6	342	59	lungs	lung	NNS
cord-326228-9x1233q6	342	60	Cutting	cut	VBG
cord-326228-9x1233q6	342	61	edge	edge	NN
cord-326228-9x1233q6	342	62	:	:	:
cord-326228-9x1233q6	343	1	role	role	NN
cord-326228-9x1233q6	343	2	of	of	IN
cord-326228-9x1233q6	343	3	toll	toll	NN
cord-326228-9x1233q6	343	4	-	-	HYPH
cord-326228-9x1233q6	343	5	like	like	JJ
cord-326228-9x1233q6	343	6	receptor	receptor	NN
cord-326228-9x1233q6	343	7	9	9	CD
cord-326228-9x1233q6	343	8	in	in	IN
cord-326228-9x1233q6	343	9	CpG	CpG	NNP
cord-326228-9x1233q6	343	10	DNA	DNA	NNP
cord-326228-9x1233q6	343	11	-	-	HYPH
cord-326228-9x1233q6	343	12	induced	induce	VBN
cord-326228-9x1233q6	343	13	activation	activation	NN
cord-326228-9x1233q6	343	14	of	of	IN
cord-326228-9x1233q6	343	15	human	human	JJ
cord-326228-9x1233q6	343	16	cells	cell	NNS
cord-326228-9x1233q6	343	17	Bacterial	bacterial	JJ
cord-326228-9x1233q6	343	18	CpG	cpg	NN
cord-326228-9x1233q6	343	19	-	-	HYPH
cord-326228-9x1233q6	343	20	DNA	DNA	NNP
cord-326228-9x1233q6	343	21	and	and	CC
cord-326228-9x1233q6	343	22	lipopolysaccharides	lipopolysaccharides	NNP
cord-326228-9x1233q6	343	23	activate	activate	VB
cord-326228-9x1233q6	343	24	toll	toll	NN
cord-326228-9x1233q6	343	25	-	-	HYPH
cord-326228-9x1233q6	343	26	like	like	JJ
cord-326228-9x1233q6	343	27	receptors	receptor	NNS
cord-326228-9x1233q6	343	28	at	at	IN
cord-326228-9x1233q6	343	29	distinct	distinct	JJ
cord-326228-9x1233q6	343	30	cellular	cellular	JJ
cord-326228-9x1233q6	343	31	compartments	compartment	NNS
cord-326228-9x1233q6	344	1	Mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	344	2	DNA	dna	NN
cord-326228-9x1233q6	344	3	and	and	CC
cord-326228-9x1233q6	344	4	TLR9	tlr9	CD
cord-326228-9x1233q6	344	5	drive	drive	NN
cord-326228-9x1233q6	344	6	muscle	muscle	NN
cord-326228-9x1233q6	344	7	inflammation	inflammation	NN
cord-326228-9x1233q6	344	8	upon	upon	IN
cord-326228-9x1233q6	344	9	Opa1	Opa1	NNP
cord-326228-9x1233q6	344	10	deficiency	deficiency	NN
cord-326228-9x1233q6	345	1	Toll	toll	NN
cord-326228-9x1233q6	345	2	-	-	HYPH
cord-326228-9x1233q6	345	3	like	like	JJ
cord-326228-9x1233q6	345	4	receptor	receptor	NN
cord-326228-9x1233q6	345	5	9	9	CD
cord-326228-9x1233q6	345	6	can	can	MD
cord-326228-9x1233q6	345	7	be	be	VB
cord-326228-9x1233q6	345	8	activated	activate	VBN
cord-326228-9x1233q6	345	9	by	by	IN
cord-326228-9x1233q6	345	10	endogenous	endogenous	JJ
cord-326228-9x1233q6	345	11	mitochondrial	mitochondrial	NN
cord-326228-9x1233q6	345	12	DNA	dna	NN
cord-326228-9x1233q6	345	13	to	to	TO
cord-326228-9x1233q6	345	14	induce	induce	VB
cord-326228-9x1233q6	345	15	podocyte	podocyte	NNP
cord-326228-9x1233q6	345	16	apoptosis	apoptosis	NN
cord-326228-9x1233q6	346	1	Mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	346	2	-	-	HYPH
cord-326228-9x1233q6	346	3	DNA	dna	NN
cord-326228-9x1233q6	346	4	-	-	HYPH
cord-326228-9x1233q6	346	5	associated	associate	VBN
cord-326228-9x1233q6	346	6	TLR9	TLR9	NNP
cord-326228-9x1233q6	346	7	signalling	signalling	NN
cord-326228-9x1233q6	346	8	is	be	VBZ
cord-326228-9x1233q6	346	9	a	a	DT
cord-326228-9x1233q6	346	10	potential	potential	JJ
cord-326228-9x1233q6	346	11	serological	serological	JJ
cord-326228-9x1233q6	346	12	biomarker	biomarker	NN
cord-326228-9x1233q6	346	13	for	for	IN
cord-326228-9x1233q6	346	14	non	non	JJ
cord-326228-9x1233q6	346	15	-	-	JJ
cord-326228-9x1233q6	346	16	small	small	JJ
cord-326228-9x1233q6	346	17	cell	cell	NN
cord-326228-9x1233q6	346	18	lung	lung	NN
cord-326228-9x1233q6	346	19	cancer	cancer	NN
cord-326228-9x1233q6	346	20	Circulating	circulate	VBG
cord-326228-9x1233q6	346	21	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	346	22	DNA	dna	NN
cord-326228-9x1233q6	346	23	and	and	CC
cord-326228-9x1233q6	346	24	Toll	Toll	NNP
cord-326228-9x1233q6	346	25	-	-	HYPH
cord-326228-9x1233q6	346	26	like	like	JJ
cord-326228-9x1233q6	346	27	receptor	receptor	NN
cord-326228-9x1233q6	346	28	9	9	CD
cord-326228-9x1233q6	346	29	are	be	VBP
cord-326228-9x1233q6	346	30	associated	associate	VBN
cord-326228-9x1233q6	346	31	with	with	IN
cord-326228-9x1233q6	346	32	vascular	vascular	JJ
cord-326228-9x1233q6	346	33	dysfunction	dysfunction	NN
cord-326228-9x1233q6	346	34	in	in	IN
cord-326228-9x1233q6	346	35	spontaneously	spontaneously	RB
cord-326228-9x1233q6	346	36	hypertensive	hypertensive	JJ
cord-326228-9x1233q6	346	37	rats	rat	NNS
cord-326228-9x1233q6	346	38	Cutting	cut	VBG
cord-326228-9x1233q6	346	39	Edge	edge	NN
cord-326228-9x1233q6	346	40	:	:	:
cord-326228-9x1233q6	347	1	TNF	TNF	NNP
cord-326228-9x1233q6	347	2	-	-	:
cord-326228-9x1233q6	347	3	a	a	NNP
cord-326228-9x1233q6	347	4	mediates	mediate	VBZ
cord-326228-9x1233q6	347	5	sensitization	sensitization	NN
cord-326228-9x1233q6	347	6	to	to	IN
cord-326228-9x1233q6	347	7	ATP	ATP	NNP
cord-326228-9x1233q6	347	8	and	and	CC
cord-326228-9x1233q6	347	9	silica	silica	NN
cord-326228-9x1233q6	347	10	via	via	IN
cord-326228-9x1233q6	347	11	the	the	DT
cord-326228-9x1233q6	347	12	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	347	13	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	347	14	in	in	IN
cord-326228-9x1233q6	347	15	the	the	DT
cord-326228-9x1233q6	347	16	absence	absence	NN
cord-326228-9x1233q6	347	17	of	of	IN
cord-326228-9x1233q6	347	18	microbial	microbial	JJ
cord-326228-9x1233q6	347	19	stimulation	stimulation	NN
cord-326228-9x1233q6	348	1	Toll	toll	NN
cord-326228-9x1233q6	348	2	-	-	HYPH
cord-326228-9x1233q6	348	3	like	like	JJ
cord-326228-9x1233q6	348	4	receptor	receptor	NN
cord-326228-9x1233q6	348	5	9	9	CD
cord-326228-9x1233q6	348	6	signaling	signaling	NN
cord-326228-9x1233q6	348	7	activates	activate	VBZ
cord-326228-9x1233q6	348	8	NF	nf	NN
cord-326228-9x1233q6	349	1	-jB	-jB	:
cord-326228-9x1233q6	350	1	through	through	IN
cord-326228-9x1233q6	350	2	IFN	IFN	NNP
cord-326228-9x1233q6	350	3	regulatory	regulatory	JJ
cord-326228-9x1233q6	350	4	factor-8	factor-8	NNP
cord-326228-9x1233q6	350	5	/	/	SYM
cord-326228-9x1233q6	350	6	IFN	IFN	NNP
cord-326228-9x1233q6	350	7	consensus	consensus	NN
cord-326228-9x1233q6	350	8	sequence	sequence	NN
cord-326228-9x1233q6	350	9	binding	bind	VBG
cord-326228-9x1233q6	350	10	protein	protein	NN
cord-326228-9x1233q6	350	11	in	in	IN
cord-326228-9x1233q6	350	12	dendritic	dendritic	JJ
cord-326228-9x1233q6	350	13	cells	cell	NNS
cord-326228-9x1233q6	350	14	AIM2	AIM2	NNP
cord-326228-9x1233q6	350	15	recognizes	recognize	VBZ
cord-326228-9x1233q6	350	16	cytosolic	cytosolic	JJ
cord-326228-9x1233q6	350	17	dsDNA	dsdna	RB
cord-326228-9x1233q6	350	18	and	and	CC
cord-326228-9x1233q6	350	19	forms	form	VBZ
cord-326228-9x1233q6	350	20	a	a	DT
cord-326228-9x1233q6	350	21	caspase-1-activating	caspase-1-activate	VBG
cord-326228-9x1233q6	350	22	inflammasome	inflammasome	NN
cord-326228-9x1233q6	350	23	with	with	IN
cord-326228-9x1233q6	350	24	ASC	ASC	NNP
cord-326228-9x1233q6	350	25	AIM2	AIM2	NNP
cord-326228-9x1233q6	350	26	inflammasome	inflammasome	NN
cord-326228-9x1233q6	350	27	in	in	IN
cord-326228-9x1233q6	350	28	infection	infection	NN
cord-326228-9x1233q6	350	29	,	,	,
cord-326228-9x1233q6	350	30	cancer	cancer	NN
cord-326228-9x1233q6	350	31	,	,	,
cord-326228-9x1233q6	350	32	and	and	CC
cord-326228-9x1233q6	350	33	autoimmunity	autoimmunity	NN
cord-326228-9x1233q6	350	34	:	:	:
cord-326228-9x1233q6	350	35	role	role	NN
cord-326228-9x1233q6	350	36	in	in	IN
cord-326228-9x1233q6	350	37	DNA	dna	NN
cord-326228-9x1233q6	350	38	sensing	sensing	NN
cord-326228-9x1233q6	350	39	,	,	,
cord-326228-9x1233q6	350	40	inflammation	inflammation	NN
cord-326228-9x1233q6	350	41	,	,	,
cord-326228-9x1233q6	350	42	and	and	CC
cord-326228-9x1233q6	350	43	innate	innate	JJ
cord-326228-9x1233q6	350	44	immunity	immunity	NN
cord-326228-9x1233q6	351	1	The	the	DT
cord-326228-9x1233q6	351	2	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	351	3	genome	genome	NN
cord-326228-9x1233q6	351	4	:	:	:
cord-326228-9x1233q6	352	1	structure	structure	NN
cord-326228-9x1233q6	352	2	,	,	,
cord-326228-9x1233q6	352	3	transcription	transcription	NN
cord-326228-9x1233q6	352	4	,	,	,
cord-326228-9x1233q6	352	5	translation	translation	NN
cord-326228-9x1233q6	352	6	and	and	CC
cord-326228-9x1233q6	352	7	replication	replication	NN
cord-326228-9x1233q6	352	8	Assembly	assembly	NN
cord-326228-9x1233q6	352	9	-	-	HYPH
cord-326228-9x1233q6	352	10	driven	drive	VBN
cord-326228-9x1233q6	352	11	activation	activation	NN
cord-326228-9x1233q6	352	12	of	of	IN
cord-326228-9x1233q6	352	13	the	the	DT
cord-326228-9x1233q6	352	14	AIM2	AIM2	NNP
cord-326228-9x1233q6	352	15	foreign	foreign	JJ
cord-326228-9x1233q6	352	16	-	-	HYPH
cord-326228-9x1233q6	352	17	dsDNA	dsdna	RB
cord-326228-9x1233q6	352	18	sensor	sensor	NN
cord-326228-9x1233q6	352	19	provides	provide	VBZ
cord-326228-9x1233q6	352	20	a	a	DT
cord-326228-9x1233q6	352	21	polymerization	polymerization	NN
cord-326228-9x1233q6	352	22	template	template	NN
cord-326228-9x1233q6	352	23	for	for	IN
cord-326228-9x1233q6	352	24	downstream	downstream	JJ
cord-326228-9x1233q6	352	25	ASC	ASC	NNP
cord-326228-9x1233q6	352	26	Circulating	circulate	VBG
cord-326228-9x1233q6	352	27	cell	cell	NN
cord-326228-9x1233q6	352	28	-	-	HYPH
cord-326228-9x1233q6	352	29	free	free	JJ
cord-326228-9x1233q6	352	30	mtDNA	mtdna	NN
cord-326228-9x1233q6	352	31	contributes	contribute	VBZ
cord-326228-9x1233q6	352	32	to	to	IN
cord-326228-9x1233q6	352	33	AIM2	AIM2	NNP
cord-326228-9x1233q6	352	34	inflammasome	inflammasome	NN
cord-326228-9x1233q6	352	35	-	-	HYPH
cord-326228-9x1233q6	352	36	mediated	mediate	VBN
cord-326228-9x1233q6	352	37	chronic	chronic	JJ
cord-326228-9x1233q6	352	38	inflammation	inflammation	NN
cord-326228-9x1233q6	352	39	in	in	IN
cord-326228-9x1233q6	352	40	patients	patient	NNS
cord-326228-9x1233q6	352	41	with	with	IN
cord-326228-9x1233q6	352	42	type	type	NN
cord-326228-9x1233q6	352	43	2	2	CD
cord-326228-9x1233q6	352	44	diabetes	diabetes	NN
cord-326228-9x1233q6	352	45	Mitochondrial	Mitochondrial	NNP
cord-326228-9x1233q6	352	46	DNA	DNA	NNP
cord-326228-9x1233q6	352	47	as	as	IN
cord-326228-9x1233q6	352	48	an	an	DT
cord-326228-9x1233q6	352	49	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	352	50	mediator	mediator	NN
cord-326228-9x1233q6	352	51	in	in	IN
cord-326228-9x1233q6	352	52	cardiovascular	cardiovascular	JJ
cord-326228-9x1233q6	352	53	diseases	disease	NNS
cord-326228-9x1233q6	353	1	Circulating	circulate	VBG
cord-326228-9x1233q6	354	1	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	354	2	DNA	dna	NN
cord-326228-9x1233q6	354	3	increases	increase	NNS
cord-326228-9x1233q6	354	4	with	with	IN
cord-326228-9x1233q6	354	5	age	age	NN
cord-326228-9x1233q6	354	6	and	and	CC
cord-326228-9x1233q6	354	7	is	be	VBZ
cord-326228-9x1233q6	354	8	a	a	DT
cord-326228-9x1233q6	354	9	familiar	familiar	JJ
cord-326228-9x1233q6	354	10	trait	trait	NN
cord-326228-9x1233q6	354	11	:	:	:
cord-326228-9x1233q6	354	12	implications	implication	NNS
cord-326228-9x1233q6	354	13	for	for	IN
cord-326228-9x1233q6	354	14	"	"	``
cord-326228-9x1233q6	354	15	inflamm	inflamm	RB
cord-326228-9x1233q6	354	16	-	-	HYPH
cord-326228-9x1233q6	354	17	aging	age	VBG
cord-326228-9x1233q6	354	18	"	"	''
cord-326228-9x1233q6	354	19	Mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	354	20	DNA	DNA	NNP
cord-326228-9x1233q6	354	21	activates	activate	VBZ
cord-326228-9x1233q6	354	22	the	the	DT
cord-326228-9x1233q6	354	23	NLRP3	nlrp3	XX
cord-326228-9x1233q6	354	24	inflammasome	inflammasome	NN
cord-326228-9x1233q6	354	25	and	and	CC
cord-326228-9x1233q6	354	26	predisposes	predispose	VBZ
cord-326228-9x1233q6	354	27	to	to	TO
cord-326228-9x1233q6	354	28	type	type	VB
cord-326228-9x1233q6	354	29	1	1	CD
cord-326228-9x1233q6	354	30	diabetes	diabetes	NN
cord-326228-9x1233q6	354	31	in	in	IN
cord-326228-9x1233q6	354	32	murine	murine	JJ
cord-326228-9x1233q6	354	33	model	model	NN
cord-326228-9x1233q6	355	1	Circulating	circulate	VBG
cord-326228-9x1233q6	355	2	cell	cell	NN
cord-326228-9x1233q6	355	3	free	free	JJ
cord-326228-9x1233q6	355	4	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	355	5	DNA	dna	NN
cord-326228-9x1233q6	355	6	is	be	VBZ
cord-326228-9x1233q6	355	7	a	a	DT
cord-326228-9x1233q6	355	8	biomarker	biomarker	NN
cord-326228-9x1233q6	355	9	in	in	IN
cord-326228-9x1233q6	355	10	the	the	DT
cord-326228-9x1233q6	355	11	development	development	NN
cord-326228-9x1233q6	355	12	of	of	IN
cord-326228-9x1233q6	355	13	coronary	coronary	JJ
cord-326228-9x1233q6	355	14	heart	heart	NN
cord-326228-9x1233q6	355	15	disease	disease	NN
cord-326228-9x1233q6	355	16	in	in	IN
cord-326228-9x1233q6	355	17	the	the	DT
cord-326228-9x1233q6	355	18	patients	patient	NNS
cord-326228-9x1233q6	355	19	with	with	IN
cord-326228-9x1233q6	355	20	type	type	NN
cord-326228-9x1233q6	355	21	2	2	CD
cord-326228-9x1233q6	355	22	diabetes	diabetes	NN
cord-326228-9x1233q6	356	1	The	the	DT
cord-326228-9x1233q6	356	2	role	role	NN
cord-326228-9x1233q6	356	3	of	of	IN
cord-326228-9x1233q6	356	4	circulating	circulate	VBG
cord-326228-9x1233q6	356	5	mitochondrial	mitochondrial	JJ
cord-326228-9x1233q6	356	6	DNA	dna	NN
cord-326228-9x1233q6	356	7	in	in	IN
cord-326228-9x1233q6	356	8	modulating	modulate	VBG
cord-326228-9x1233q6	356	9	airway	airway	NN
cord-326228-9x1233q6	356	10	inflammation	inflammation	NN
cord-326228-9x1233q6	356	11	of	of	IN
cord-326228-9x1233q6	356	12	chronic	chronic	JJ
cord-326228-9x1233q6	356	13	obstructive	obstructive	JJ
cord-326228-9x1233q6	356	14	pulmonary	pulmonary	JJ
cord-326228-9x1233q6	356	15	disease	disease	NN
cord-326228-9x1233q6	357	1	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	358	1	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	358	2	is	be	VBZ
cord-326228-9x1233q6	358	3	essential	essential	JJ
cord-326228-9x1233q6	358	4	for	for	IN
cord-326228-9x1233q6	358	5	the	the	DT
cord-326228-9x1233q6	358	6	development	development	NN
cord-326228-9x1233q6	358	7	of	of	IN
cord-326228-9x1233q6	358	8	chronic	chronic	JJ
cord-326228-9x1233q6	358	9	obstructive	obstructive	JJ
cord-326228-9x1233q6	358	10	pulmonary	pulmonary	JJ
cord-326228-9x1233q6	358	11	disease	disease	NN
cord-326228-9x1233q6	358	12	New	new	JJ
cord-326228-9x1233q6	358	13	insights	insight	NNS
cord-326228-9x1233q6	358	14	into	into	IN
cord-326228-9x1233q6	358	15	the	the	DT
cord-326228-9x1233q6	358	16	complex	complex	JJ
cord-326228-9x1233q6	358	17	role	role	NN
cord-326228-9x1233q6	358	18	of	of	IN
cord-326228-9x1233q6	358	19	mitochondria	mitochondrion	NNS
cord-326228-9x1233q6	358	20	in	in	IN
cord-326228-9x1233q6	358	21	Parkinson	Parkinson	NNP
cord-326228-9x1233q6	358	22	's	's	POS
cord-326228-9x1233q6	358	23	disease	disease	NN
cord-326228-9x1233q6	358	24	A	a	DT
cord-326228-9x1233q6	358	25	small	small	JJ
cord-326228-9x1233q6	358	26	-	-	HYPH
cord-326228-9x1233q6	358	27	molecule	molecule	NN
cord-326228-9x1233q6	358	28	inhibitor	inhibitor	NN
cord-326228-9x1233q6	358	29	of	of	IN
cord-326228-9x1233q6	358	30	the	the	DT
cord-326228-9x1233q6	358	31	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	358	32	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	358	33	for	for	IN
cord-326228-9x1233q6	358	34	the	the	DT
cord-326228-9x1233q6	358	35	treatment	treatment	NN
cord-326228-9x1233q6	358	36	of	of	IN
cord-326228-9x1233q6	358	37	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	358	38	diseases	disease	NNS
cord-326228-9x1233q6	358	39	MCC950	mcc950	VBP
cord-326228-9x1233q6	358	40	directly	directly	RB
cord-326228-9x1233q6	358	41	targets	target	VBZ
cord-326228-9x1233q6	358	42	the	the	DT
cord-326228-9x1233q6	358	43	NLRP3	nlrp3	NN
cord-326228-9x1233q6	358	44	ATP	ATP	NNP
cord-326228-9x1233q6	358	45	-	-	HYPH
cord-326228-9x1233q6	358	46	hydrolysis	hydrolysis	NN
cord-326228-9x1233q6	358	47	motif	motif	NN
cord-326228-9x1233q6	358	48	for	for	IN
cord-326228-9x1233q6	358	49	inflammasome	inflammasome	NN
cord-326228-9x1233q6	358	50	inhibition	inhibition	NN
cord-326228-9x1233q6	358	51	Sterile	sterile	JJ
cord-326228-9x1233q6	358	52	signals	signal	NNS
cord-326228-9x1233q6	358	53	generate	generate	VBP
cord-326228-9x1233q6	358	54	weaker	weak	JJR
cord-326228-9x1233q6	358	55	and	and	CC
cord-326228-9x1233q6	358	56	delayed	delay	VBN
cord-326228-9x1233q6	358	57	macrophage	macrophage	NN
cord-326228-9x1233q6	358	58	NLRP3	nlrp3	NN
cord-326228-9x1233q6	358	59	inflammasome	inflammasome	NN
cord-326228-9x1233q6	358	60	responses	response	NNS
cord-326228-9x1233q6	358	61	relative	relative	JJ
cord-326228-9x1233q6	358	62	to	to	IN
cord-326228-9x1233q6	358	63	microbial	microbial	JJ
cord-326228-9x1233q6	358	64	signals	signal	NNS
cord-326228-9x1233q6	359	1	KS	KS	NNP
cord-326228-9x1233q6	359	2	is	be	VBZ
cord-326228-9x1233q6	359	3	a	a	DT
cord-326228-9x1233q6	359	4	co	co	NN
cord-326228-9x1233q6	359	5	-	-	NN
cord-326228-9x1233q6	359	6	inventor	inventor	NN
cord-326228-9x1233q6	359	7	on	on	IN
cord-326228-9x1233q6	359	8	patent	patent	NN
cord-326228-9x1233q6	359	9	applications	application	NNS
cord-326228-9x1233q6	359	10	for	for	IN
cord-326228-9x1233q6	359	11	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	359	12	inhibitors	inhibitor	NNS
cord-326228-9x1233q6	359	13	which	which	WDT
cord-326228-9x1233q6	359	14	have	have	VBP
cord-326228-9x1233q6	359	15	been	be	VBN
cord-326228-9x1233q6	359	16	licensed	license	VBN
cord-326228-9x1233q6	359	17	to	to	IN
cord-326228-9x1233q6	359	18	Inflazome	Inflazome	NNP
cord-326228-9x1233q6	359	19	Ltd	Ltd	NNP
cord-326228-9x1233q6	359	20	,	,	,
cord-326228-9x1233q6	359	21	a	a	DT
cord-326228-9x1233q6	359	22	company	company	NN
cord-326228-9x1233q6	359	23	headquartered	headquarter	VBN
cord-326228-9x1233q6	359	24	in	in	IN
cord-326228-9x1233q6	359	25	Dublin	Dublin	NNP
cord-326228-9x1233q6	359	26	,	,	,
cord-326228-9x1233q6	359	27	Ireland	Ireland	NNP
cord-326228-9x1233q6	359	28	.	.	.
cord-326228-9x1233q6	360	1	Inflazome	Inflazome	NNP
cord-326228-9x1233q6	360	2	is	be	VBZ
cord-326228-9x1233q6	360	3	developing	develop	VBG
cord-326228-9x1233q6	360	4	drugs	drug	NNS
cord-326228-9x1233q6	360	5	that	that	WDT
cord-326228-9x1233q6	360	6	target	target	VBP
cord-326228-9x1233q6	360	7	the	the	DT
cord-326228-9x1233q6	360	8	NLRP3	NLRP3	NNP
cord-326228-9x1233q6	360	9	inflammasome	inflammasome	NNP
cord-326228-9x1233q6	360	10	to	to	TO
cord-326228-9x1233q6	360	11	address	address	VB
cord-326228-9x1233q6	360	12	unmet	unmet	JJ
cord-326228-9x1233q6	360	13	clinical	clinical	JJ
cord-326228-9x1233q6	360	14	needs	need	NNS
cord-326228-9x1233q6	360	15	in	in	IN
cord-326228-9x1233q6	360	16	inflammatory	inflammatory	JJ
cord-326228-9x1233q6	360	17	diseases	disease	NNS
cord-326228-9x1233q6	360	18	.	.	.
cord-326228-9x1233q6	361	1	KS	KS	NNP
cord-326228-9x1233q6	361	2	served	serve	VBD
cord-326228-9x1233q6	361	3	on	on	IN
cord-326228-9x1233q6	361	4	the	the	DT
cord-326228-9x1233q6	361	5	Scientific	Scientific	NNP
cord-326228-9x1233q6	361	6	Advisory	Advisory	NNP
cord-326228-9x1233q6	361	7	Board	Board	NNP
cord-326228-9x1233q6	361	8	of	of	IN
cord-326228-9x1233q6	361	9	Inflazome	Inflazome	NNP
cord-326228-9x1233q6	361	10	in	in	IN
cord-326228-9x1233q6	361	11	2016	2016	CD
cord-326228-9x1233q6	361	12	-	-	SYM
cord-326228-9x1233q6	361	13	2017	2017	CD
cord-326228-9x1233q6	361	14	.	.	.
cord-326228-9x1233q6	362	1	KS	KS	NNP
cord-326228-9x1233q6	362	2	is	be	VBZ
cord-326228-9x1233q6	362	3	a	a	DT
cord-326228-9x1233q6	362	4	consultant	consultant	NN
cord-326228-9x1233q6	362	5	for	for	IN
cord-326228-9x1233q6	362	6	Quench	Quench	NNP
cord-326228-9x1233q6	362	7	Bio	Bio	NNP
cord-326228-9x1233q6	362	8	,	,	,
cord-326228-9x1233q6	362	9	USA	USA	NNP
cord-326228-9x1233q6	362	10	.	.	.
cord-326228-9x1233q6	363	1	The	the	DT
cord-326228-9x1233q6	363	2	authors	author	NNS
cord-326228-9x1233q6	363	3	have	have	VBP
cord-326228-9x1233q6	363	4	no	no	DT
cord-326228-9x1233q6	363	5	further	further	JJ
cord-326228-9x1233q6	363	6	conflicts	conflict	NNS
cord-326228-9x1233q6	363	7	of	of	IN
cord-326228-9x1233q6	363	8	interest	interest	NN
cord-326228-9x1233q6	363	9	to	to	TO
cord-326228-9x1233q6	363	10	declare	declare	VB
cord-326228-9x1233q6	363	11	.	.	.
cord-326228-9x1233q6	364	1	This	this	DT
cord-326228-9x1233q6	364	2	is	be	VBZ
cord-326228-9x1233q6	364	3	an	an	DT
cord-326228-9x1233q6	364	4	open	open	JJ
cord-326228-9x1233q6	364	5	access	access	NN
cord-326228-9x1233q6	364	6	article	article	NN
cord-326228-9x1233q6	364	7	under	under	IN
cord-326228-9x1233q6	364	8	the	the	DT
cord-326228-9x1233q6	364	9	terms	term	NNS
cord-326228-9x1233q6	364	10	of	of	IN
cord-326228-9x1233q6	364	11	the	the	DT
cord-326228-9x1233q6	364	12	Creative	Creative	NNP
cord-326228-9x1233q6	364	13	Commons	Commons	NNP
cord-326228-9x1233q6	364	14	Attribution	Attribution	NNP
cord-326228-9x1233q6	364	15	-	-	HYPH
cord-326228-9x1233q6	364	16	NonCommerc	NonCommerc	NNP
cord-326228-9x1233q6	364	17	ial	ial	NNP
cord-326228-9x1233q6	364	18	-	-	HYPH
cord-326228-9x1233q6	364	19	NoDerivs	NoDerivs	NNP
cord-326228-9x1233q6	364	20	License	License	NNP
cord-326228-9x1233q6	364	21	,	,	,
cord-326228-9x1233q6	364	22	which	which	WDT
cord-326228-9x1233q6	364	23	permits	permit	VBZ
cord-326228-9x1233q6	364	24	use	use	NN
cord-326228-9x1233q6	364	25	and	and	CC
cord-326228-9x1233q6	364	26	distribution	distribution	NN
cord-326228-9x1233q6	364	27	in	in	IN
cord-326228-9x1233q6	364	28	any	any	DT
cord-326228-9x1233q6	364	29	medium	medium	NN
cord-326228-9x1233q6	364	30	,	,	,
cord-326228-9x1233q6	364	31	provided	provide	VBD
cord-326228-9x1233q6	364	32	the	the	DT
cord-326228-9x1233q6	364	33	original	original	JJ
cord-326228-9x1233q6	364	34	work	work	NN
cord-326228-9x1233q6	364	35	is	be	VBZ
cord-326228-9x1233q6	364	36	properly	properly	RB
cord-326228-9x1233q6	364	37	cited	cite	VBN
cord-326228-9x1233q6	364	38	,	,	,
cord-326228-9x1233q6	364	39	the	the	DT
cord-326228-9x1233q6	364	40	use	use	NN
cord-326228-9x1233q6	364	41	is	be	VBZ
cord-326228-9x1233q6	364	42	noncommercial	noncommercial	JJ
cord-326228-9x1233q6	364	43	and	and	CC
cord-326228-9x1233q6	364	44	no	no	DT
cord-326228-9x1233q6	364	45	modifications	modification	NNS
cord-326228-9x1233q6	364	46	or	or	CC
cord-326228-9x1233q6	364	47	adaptations	adaptation	NNS
cord-326228-9x1233q6	364	48	are	be	VBP
cord-326228-9x1233q6	364	49	made	make	VBN
cord-326228-9x1233q6	364	50	.	.	.