id	sid	tid	token	lemma	pos
cord-310268-8q4tk6fd	1	1	key	key	JJ
cord-310268-8q4tk6fd	1	2	:	:	:
cord-310268-8q4tk6fd	1	3	cord-310268	cord-310268	NNP
cord-310268-8q4tk6fd	1	4	-	-	HYPH
cord-310268-8q4tk6fd	1	5	8q4tk6fd	8q4tk6fd	CD
cord-310268-8q4tk6fd	1	6	authors	author	NNS
cord-310268-8q4tk6fd	1	7	:	:	:
cord-310268-8q4tk6fd	1	8	Zhu	Zhu	NNP
cord-310268-8q4tk6fd	1	9	,	,	,
cord-310268-8q4tk6fd	1	10	Qinchang	Qinchang	NNP
cord-310268-8q4tk6fd	1	11	;	;	:
cord-310268-8q4tk6fd	1	12	Liu	Liu	NNP
cord-310268-8q4tk6fd	1	13	,	,	,
cord-310268-8q4tk6fd	1	14	Ge	Ge	NNP
cord-310268-8q4tk6fd	1	15	;	;	:
cord-310268-8q4tk6fd	1	16	Kai	Kai	NNP
cord-310268-8q4tk6fd	1	17	,	,	,
cord-310268-8q4tk6fd	2	1	Masaaki	Masaaki	NNP
cord-310268-8q4tk6fd	2	2	title	title	NN
cord-310268-8q4tk6fd	2	3	:	:	:
cord-310268-8q4tk6fd	2	4	DNA	DNA	NNP
cord-310268-8q4tk6fd	2	5	Aptamers	Aptamers	NNP
cord-310268-8q4tk6fd	2	6	in	in	IN
cord-310268-8q4tk6fd	2	7	the	the	DT
cord-310268-8q4tk6fd	2	8	Diagnosis	Diagnosis	NNP
cord-310268-8q4tk6fd	2	9	and	and	CC
cord-310268-8q4tk6fd	2	10	Treatment	Treatment	NNP
cord-310268-8q4tk6fd	2	11	of	of	IN
cord-310268-8q4tk6fd	2	12	Human	Human	NNP
cord-310268-8q4tk6fd	2	13	Diseases	Diseases	NNPS
cord-310268-8q4tk6fd	2	14	date	date	NN
cord-310268-8q4tk6fd	2	15	:	:	:
cord-310268-8q4tk6fd	2	16	2015	2015	CD
cord-310268-8q4tk6fd	2	17	-	-	SYM
cord-310268-8q4tk6fd	2	18	11	11	CD
cord-310268-8q4tk6fd	2	19	-	-	SYM
cord-310268-8q4tk6fd	2	20	25	25	CD
cord-310268-8q4tk6fd	2	21	journal	journal	NN
cord-310268-8q4tk6fd	2	22	:	:	:
cord-310268-8q4tk6fd	3	1	Molecules	molecule	NNS
cord-310268-8q4tk6fd	3	2	DOI	DOI	NNP
cord-310268-8q4tk6fd	3	3	:	:	:
cord-310268-8q4tk6fd	4	1	10.3390	10.3390	CD
cord-310268-8q4tk6fd	4	2	/	/	SYM
cord-310268-8q4tk6fd	4	3	molecules201219739	molecules201219739	NNP
cord-310268-8q4tk6fd	4	4	sha	sha	NNP
cord-310268-8q4tk6fd	4	5	:	:	:
cord-310268-8q4tk6fd	5	1	8d0dc902f68228a84345abe956a41bb58ea01ef3	8d0dc902f68228a84345abe956a41bb58ea01ef3	CD
cord-310268-8q4tk6fd	5	2	doc_id	doc_id	CD
cord-310268-8q4tk6fd	5	3	:	:	:
cord-310268-8q4tk6fd	6	1	310268	310268	CD
cord-310268-8q4tk6fd	6	2	cord_uid	cord_uid	NNS
cord-310268-8q4tk6fd	6	3	:	:	:
cord-310268-8q4tk6fd	7	1	8q4tk6fd	8q4tk6fd	NNP
cord-310268-8q4tk6fd	7	2	Aptamers	Aptamers	NNPS
cord-310268-8q4tk6fd	7	3	have	have	VBP
cord-310268-8q4tk6fd	7	4	a	a	DT
cord-310268-8q4tk6fd	7	5	promising	promising	JJ
cord-310268-8q4tk6fd	7	6	role	role	NN
cord-310268-8q4tk6fd	7	7	in	in	IN
cord-310268-8q4tk6fd	7	8	the	the	DT
cord-310268-8q4tk6fd	7	9	field	field	NN
cord-310268-8q4tk6fd	7	10	of	of	IN
cord-310268-8q4tk6fd	7	11	life	life	NN
cord-310268-8q4tk6fd	7	12	science	science	NN
cord-310268-8q4tk6fd	7	13	and	and	CC
cord-310268-8q4tk6fd	7	14	have	have	VBP
cord-310268-8q4tk6fd	7	15	been	be	VBN
cord-310268-8q4tk6fd	7	16	extensively	extensively	RB
cord-310268-8q4tk6fd	7	17	researched	research	VBN
cord-310268-8q4tk6fd	7	18	for	for	IN
cord-310268-8q4tk6fd	7	19	application	application	NN
cord-310268-8q4tk6fd	7	20	as	as	IN
cord-310268-8q4tk6fd	7	21	analytical	analytical	JJ
cord-310268-8q4tk6fd	7	22	tools	tool	NNS
cord-310268-8q4tk6fd	7	23	,	,	,
cord-310268-8q4tk6fd	7	24	therapeutic	therapeutic	JJ
cord-310268-8q4tk6fd	7	25	agents	agent	NNS
cord-310268-8q4tk6fd	7	26	and	and	CC
cord-310268-8q4tk6fd	7	27	as	as	IN
cord-310268-8q4tk6fd	7	28	vehicles	vehicle	NNS
cord-310268-8q4tk6fd	7	29	for	for	IN
cord-310268-8q4tk6fd	7	30	targeted	target	VBN
cord-310268-8q4tk6fd	7	31	drug	drug	NN
cord-310268-8q4tk6fd	7	32	delivery	delivery	NN
cord-310268-8q4tk6fd	7	33	.	.	.
cord-310268-8q4tk6fd	8	1	Compared	compare	VBN
cord-310268-8q4tk6fd	8	2	with	with	IN
cord-310268-8q4tk6fd	8	3	RNA	RNA	NNP
cord-310268-8q4tk6fd	8	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	8	5	,	,	,
cord-310268-8q4tk6fd	8	6	DNA	DNA	NNP
cord-310268-8q4tk6fd	8	7	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	8	8	have	have	VBP
cord-310268-8q4tk6fd	8	9	inherent	inherent	JJ
cord-310268-8q4tk6fd	8	10	advantages	advantage	NNS
cord-310268-8q4tk6fd	8	11	in	in	IN
cord-310268-8q4tk6fd	8	12	stability	stability	NN
cord-310268-8q4tk6fd	8	13	and	and	CC
cord-310268-8q4tk6fd	8	14	facility	facility	NN
cord-310268-8q4tk6fd	8	15	of	of	IN
cord-310268-8q4tk6fd	8	16	generation	generation	NN
cord-310268-8q4tk6fd	8	17	and	and	CC
cord-310268-8q4tk6fd	8	18	synthesis	synthesis	NN
cord-310268-8q4tk6fd	8	19	.	.	.
cord-310268-8q4tk6fd	9	1	To	to	TO
cord-310268-8q4tk6fd	9	2	better	well	RBR
cord-310268-8q4tk6fd	9	3	understand	understand	VB
cord-310268-8q4tk6fd	9	4	the	the	DT
cord-310268-8q4tk6fd	9	5	specific	specific	JJ
cord-310268-8q4tk6fd	9	6	potential	potential	NN
cord-310268-8q4tk6fd	9	7	of	of	IN
cord-310268-8q4tk6fd	9	8	DNA	DNA	NNP
cord-310268-8q4tk6fd	9	9	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	9	10	,	,	,
cord-310268-8q4tk6fd	9	11	an	an	DT
cord-310268-8q4tk6fd	9	12	overview	overview	NN
cord-310268-8q4tk6fd	9	13	of	of	IN
cord-310268-8q4tk6fd	9	14	the	the	DT
cord-310268-8q4tk6fd	9	15	progress	progress	NN
cord-310268-8q4tk6fd	9	16	in	in	IN
cord-310268-8q4tk6fd	9	17	the	the	DT
cord-310268-8q4tk6fd	9	18	generation	generation	NN
cord-310268-8q4tk6fd	9	19	and	and	CC
cord-310268-8q4tk6fd	9	20	application	application	NN
cord-310268-8q4tk6fd	9	21	of	of	IN
cord-310268-8q4tk6fd	9	22	DNA	DNA	NNP
cord-310268-8q4tk6fd	9	23	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	9	24	in	in	IN
cord-310268-8q4tk6fd	9	25	human	human	JJ
cord-310268-8q4tk6fd	9	26	disease	disease	NN
cord-310268-8q4tk6fd	9	27	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	9	28	and	and	CC
cord-310268-8q4tk6fd	9	29	therapy	therapy	NN
cord-310268-8q4tk6fd	9	30	are	be	VBP
cord-310268-8q4tk6fd	9	31	presented	present	VBN
cord-310268-8q4tk6fd	9	32	in	in	IN
cord-310268-8q4tk6fd	9	33	this	this	DT
cord-310268-8q4tk6fd	9	34	review	review	NN
cord-310268-8q4tk6fd	9	35	.	.	.
cord-310268-8q4tk6fd	10	1	Special	special	JJ
cord-310268-8q4tk6fd	10	2	attention	attention	NN
cord-310268-8q4tk6fd	10	3	is	be	VBZ
cord-310268-8q4tk6fd	10	4	given	give	VBN
cord-310268-8q4tk6fd	10	5	to	to	IN
cord-310268-8q4tk6fd	10	6	researches	research	NNS
cord-310268-8q4tk6fd	10	7	that	that	WDT
cord-310268-8q4tk6fd	10	8	are	be	VBP
cord-310268-8q4tk6fd	10	9	relatively	relatively	RB
cord-310268-8q4tk6fd	10	10	close	close	JJ
cord-310268-8q4tk6fd	10	11	to	to	IN
cord-310268-8q4tk6fd	10	12	practical	practical	JJ
cord-310268-8q4tk6fd	10	13	application	application	NN
cord-310268-8q4tk6fd	10	14	.	.	.
cord-310268-8q4tk6fd	11	1	DNA	DNA	NNP
cord-310268-8q4tk6fd	11	2	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	11	3	are	be	VBP
cord-310268-8q4tk6fd	11	4	expected	expect	VBN
cord-310268-8q4tk6fd	11	5	to	to	TO
cord-310268-8q4tk6fd	11	6	have	have	VB
cord-310268-8q4tk6fd	11	7	great	great	JJ
cord-310268-8q4tk6fd	11	8	potential	potential	NN
cord-310268-8q4tk6fd	11	9	in	in	IN
cord-310268-8q4tk6fd	11	10	the	the	DT
cord-310268-8q4tk6fd	11	11	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	11	12	and	and	CC
cord-310268-8q4tk6fd	11	13	treatment	treatment	NN
cord-310268-8q4tk6fd	11	14	of	of	IN
cord-310268-8q4tk6fd	11	15	human	human	JJ
cord-310268-8q4tk6fd	11	16	diseases	disease	NNS
cord-310268-8q4tk6fd	11	17	.	.	.
cord-310268-8q4tk6fd	12	1	Aptamers	aptamer	NNS
cord-310268-8q4tk6fd	12	2	can	can	MD
cord-310268-8q4tk6fd	12	3	be	be	VB
cord-310268-8q4tk6fd	12	4	broadly	broadly	RB
cord-310268-8q4tk6fd	12	5	defined	define	VBN
cord-310268-8q4tk6fd	12	6	as	as	IN
cord-310268-8q4tk6fd	12	7	short	short	JJ
cord-310268-8q4tk6fd	12	8	biomolecules	biomolecule	NNS
cord-310268-8q4tk6fd	12	9	like	like	IN
cord-310268-8q4tk6fd	12	10	oligonucleotides	oligonucleotide	NNS
cord-310268-8q4tk6fd	12	11	and	and	CC
cord-310268-8q4tk6fd	12	12	peptides	peptide	NNS
cord-310268-8q4tk6fd	12	13	that	that	WDT
cord-310268-8q4tk6fd	12	14	bind	bind	VBP
cord-310268-8q4tk6fd	12	15	to	to	IN
cord-310268-8q4tk6fd	12	16	specific	specific	JJ
cord-310268-8q4tk6fd	12	17	targets	target	NNS
cord-310268-8q4tk6fd	12	18	with	with	IN
cord-310268-8q4tk6fd	12	19	extremely	extremely	RB
cord-310268-8q4tk6fd	12	20	high	high	JJ
cord-310268-8q4tk6fd	12	21	affinity	affinity	NN
cord-310268-8q4tk6fd	12	22	based	base	VBN
cord-310268-8q4tk6fd	12	23	on	on	IN
cord-310268-8q4tk6fd	12	24	their	-PRON-	PRP$
cord-310268-8q4tk6fd	12	25	structural	structural	JJ
cord-310268-8q4tk6fd	12	26	conformations	conformation	NNS
cord-310268-8q4tk6fd	12	27	.	.	.
cord-310268-8q4tk6fd	13	1	Since	since	IN
cord-310268-8q4tk6fd	13	2	the	the	DT
cord-310268-8q4tk6fd	13	3	early	early	JJ
cord-310268-8q4tk6fd	13	4	1990s	1990	NNS
cord-310268-8q4tk6fd	13	5	,	,	,
cord-310268-8q4tk6fd	13	6	systematic	systematic	JJ
cord-310268-8q4tk6fd	13	7	evolution	evolution	NN
cord-310268-8q4tk6fd	13	8	of	of	IN
cord-310268-8q4tk6fd	13	9	ligands	ligand	NNS
cord-310268-8q4tk6fd	13	10	by	by	IN
cord-310268-8q4tk6fd	13	11	exponential	exponential	JJ
cord-310268-8q4tk6fd	13	12	enrichment	enrichment	NN
cord-310268-8q4tk6fd	13	13	(	(	-LRB-
cord-310268-8q4tk6fd	13	14	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	13	15	)	)	-RRB-
cord-310268-8q4tk6fd	13	16	and	and	CC
cord-310268-8q4tk6fd	13	17	similar	similar	JJ
cord-310268-8q4tk6fd	13	18	methods	method	NNS
cord-310268-8q4tk6fd	13	19	have	have	VBP
cord-310268-8q4tk6fd	13	20	been	be	VBN
cord-310268-8q4tk6fd	13	21	reported	report	VBN
cord-310268-8q4tk6fd	13	22	to	to	TO
cord-310268-8q4tk6fd	13	23	efficiently	efficiently	RB
cord-310268-8q4tk6fd	13	24	select	select	VB
cord-310268-8q4tk6fd	13	25	RNA	RNA	NNP
cord-310268-8q4tk6fd	13	26	and	and	CC
cord-310268-8q4tk6fd	13	27	DNA	DNA	NNP
cord-310268-8q4tk6fd	13	28	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	13	29	[	[	-LRB-
cord-310268-8q4tk6fd	13	30	1	1	CD
cord-310268-8q4tk6fd	13	31	]	]	-RRB-
cord-310268-8q4tk6fd	13	32	[	[	-LRB-
cord-310268-8q4tk6fd	13	33	2	2	CD
cord-310268-8q4tk6fd	13	34	]	]	-RRB-
cord-310268-8q4tk6fd	13	35	[	[	-LRB-
cord-310268-8q4tk6fd	13	36	3	3	CD
cord-310268-8q4tk6fd	13	37	]	]	-RRB-
cord-310268-8q4tk6fd	13	38	[	[	-LRB-
cord-310268-8q4tk6fd	13	39	4	4	CD
cord-310268-8q4tk6fd	13	40	]	]	-RRB-
cord-310268-8q4tk6fd	13	41	.	.	.
cord-310268-8q4tk6fd	14	1	Thereafter	thereafter	RB
cord-310268-8q4tk6fd	14	2	,	,	,
cord-310268-8q4tk6fd	14	3	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	14	4	acid	acid	NN
cord-310268-8q4tk6fd	14	5	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	14	6	have	have	VBP
cord-310268-8q4tk6fd	14	7	been	be	VBN
cord-310268-8q4tk6fd	14	8	extensively	extensively	RB
cord-310268-8q4tk6fd	14	9	researched	research	VBN
cord-310268-8q4tk6fd	14	10	and	and	CC
cord-310268-8q4tk6fd	14	11	applied	apply	VBN
cord-310268-8q4tk6fd	14	12	.	.	.
cord-310268-8q4tk6fd	15	1	Nucleic	nucleic	JJ
cord-310268-8q4tk6fd	15	2	acid	acid	NN
cord-310268-8q4tk6fd	15	3	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	15	4	are	be	VBP
cord-310268-8q4tk6fd	15	5	RNA	RNA	NNP
cord-310268-8q4tk6fd	15	6	and	and	CC
cord-310268-8q4tk6fd	15	7	single	single	RB
cord-310268-8q4tk6fd	15	8	-	-	HYPH
cord-310268-8q4tk6fd	15	9	stranded	stranded	JJ
cord-310268-8q4tk6fd	15	10	(	(	-LRB-
cord-310268-8q4tk6fd	15	11	ss	ss	NNP
cord-310268-8q4tk6fd	15	12	)	)	-RRB-
cord-310268-8q4tk6fd	15	13	DNA	dna	NN
cord-310268-8q4tk6fd	15	14	oligonucleotides	oligonucleotide	NNS
cord-310268-8q4tk6fd	15	15	with	with	IN
cord-310268-8q4tk6fd	15	16	lengths	length	NNS
cord-310268-8q4tk6fd	15	17	typically	typically	RB
cord-310268-8q4tk6fd	15	18	ranging	range	VBG
cord-310268-8q4tk6fd	15	19	from	from	IN
cord-310268-8q4tk6fd	15	20	15	15	CD
cord-310268-8q4tk6fd	15	21	to	to	TO
cord-310268-8q4tk6fd	15	22	70	70	CD
cord-310268-8q4tk6fd	15	23	mers	mer	NNS
cord-310268-8q4tk6fd	15	24	,	,	,
cord-310268-8q4tk6fd	15	25	which	which	WDT
cord-310268-8q4tk6fd	15	26	have	have	VBP
cord-310268-8q4tk6fd	15	27	the	the	DT
cord-310268-8q4tk6fd	15	28	same	same	JJ
cord-310268-8q4tk6fd	15	29	level	level	NN
cord-310268-8q4tk6fd	15	30	of	of	IN
cord-310268-8q4tk6fd	15	31	target	target	NN
cord-310268-8q4tk6fd	15	32	-	-	HYPH
cord-310268-8q4tk6fd	15	33	binding	bind	VBG
cord-310268-8q4tk6fd	15	34	affinity	affinity	NN
cord-310268-8q4tk6fd	15	35	as	as	IN
cord-310268-8q4tk6fd	15	36	monoclonal	monoclonal	JJ
cord-310268-8q4tk6fd	15	37	antibodies	antibody	NNS
cord-310268-8q4tk6fd	15	38	(	(	-LRB-
cord-310268-8q4tk6fd	15	39	the	the	DT
cord-310268-8q4tk6fd	15	40	dissociation	dissociation	NN
cord-310268-8q4tk6fd	15	41	constant	constant	NN
cord-310268-8q4tk6fd	15	42	(	(	-LRB-
cord-310268-8q4tk6fd	15	43	K	K	NNP
cord-310268-8q4tk6fd	15	44	d	d	NN
cord-310268-8q4tk6fd	15	45	)	)	-RRB-
cord-310268-8q4tk6fd	15	46	usually	usually	RB
cord-310268-8q4tk6fd	15	47	ranges	range	VBZ
cord-310268-8q4tk6fd	15	48	from	from	IN
cord-310268-8q4tk6fd	15	49	0.1	0.1	CD
cord-310268-8q4tk6fd	15	50	to	to	TO
cord-310268-8q4tk6fd	15	51	50	50	CD
cord-310268-8q4tk6fd	15	52	nM	nm	NN
cord-310268-8q4tk6fd	15	53	)	)	-RRB-
cord-310268-8q4tk6fd	15	54	[	[	-LRB-
cord-310268-8q4tk6fd	15	55	5	5	CD
cord-310268-8q4tk6fd	15	56	,	,	,
cord-310268-8q4tk6fd	15	57	6	6	CD
cord-310268-8q4tk6fd	15	58	]	]	-RRB-
cord-310268-8q4tk6fd	15	59	.	.	.
cord-310268-8q4tk6fd	16	1	Compared	compare	VBN
cord-310268-8q4tk6fd	16	2	with	with	IN
cord-310268-8q4tk6fd	16	3	antibodies	antibody	NNS
cord-310268-8q4tk6fd	16	4	,	,	,
cord-310268-8q4tk6fd	16	5	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	16	6	acid	acid	NN
cord-310268-8q4tk6fd	16	7	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	16	8	have	have	VBP
cord-310268-8q4tk6fd	16	9	many	many	JJ
cord-310268-8q4tk6fd	16	10	advantages	advantage	NNS
cord-310268-8q4tk6fd	16	11	in	in	IN
cord-310268-8q4tk6fd	16	12	their	-PRON-	PRP$
cord-310268-8q4tk6fd	16	13	suitability	suitability	NN
cord-310268-8q4tk6fd	16	14	for	for	IN
cord-310268-8q4tk6fd	16	15	clinical	clinical	JJ
cord-310268-8q4tk6fd	16	16	application	application	NN
cord-310268-8q4tk6fd	16	17	and	and	CC
cord-310268-8q4tk6fd	16	18	industrialization	industrialization	NN
cord-310268-8q4tk6fd	16	19	,	,	,
cord-310268-8q4tk6fd	16	20	including	include	VBG
cord-310268-8q4tk6fd	16	21	almost	almost	RB
cord-310268-8q4tk6fd	16	22	no	no	DT
cord-310268-8q4tk6fd	16	23	immunogenicity	immunogenicity	NN
cord-310268-8q4tk6fd	16	24	,	,	,
cord-310268-8q4tk6fd	16	25	efficient	efficient	JJ
cord-310268-8q4tk6fd	16	26	penetration	penetration	NN
cord-310268-8q4tk6fd	16	27	,	,	,
cord-310268-8q4tk6fd	16	28	less	less	JJR
cord-310268-8q4tk6fd	16	29	batch	batch	NN
cord-310268-8q4tk6fd	16	30	variation	variation	NN
cord-310268-8q4tk6fd	16	31	,	,	,
cord-310268-8q4tk6fd	16	32	easy	easy	JJ
cord-310268-8q4tk6fd	16	33	modification	modification	NN
cord-310268-8q4tk6fd	16	34	,	,	,
cord-310268-8q4tk6fd	16	35	cost	cost	NN
cord-310268-8q4tk6fd	16	36	-	-	HYPH
cord-310268-8q4tk6fd	16	37	effectiveness	effectiveness	NN
cord-310268-8q4tk6fd	16	38	and	and	CC
cord-310268-8q4tk6fd	16	39	short	short	JJ
cord-310268-8q4tk6fd	16	40	production	production	NN
cord-310268-8q4tk6fd	16	41	times	time	NNS
cord-310268-8q4tk6fd	16	42	[	[	-LRB-
cord-310268-8q4tk6fd	16	43	5	5	CD
cord-310268-8q4tk6fd	16	44	,	,	,
cord-310268-8q4tk6fd	16	45	7	7	CD
cord-310268-8q4tk6fd	16	46	]	]	-RRB-
cord-310268-8q4tk6fd	16	47	.	.	.
cord-310268-8q4tk6fd	17	1	In	in	IN
cord-310268-8q4tk6fd	17	2	the	the	DT
cord-310268-8q4tk6fd	17	3	past	past	JJ
cord-310268-8q4tk6fd	17	4	25	25	CD
cord-310268-8q4tk6fd	17	5	years	year	NNS
cord-310268-8q4tk6fd	17	6	,	,	,
cord-310268-8q4tk6fd	17	7	much	much	JJ
cord-310268-8q4tk6fd	17	8	progress	progress	NN
cord-310268-8q4tk6fd	17	9	has	have	VBZ
cord-310268-8q4tk6fd	17	10	been	be	VBN
cord-310268-8q4tk6fd	17	11	made	make	VBN
cord-310268-8q4tk6fd	17	12	in	in	IN
cord-310268-8q4tk6fd	17	13	the	the	DT
cord-310268-8q4tk6fd	17	14	use	use	NN
cord-310268-8q4tk6fd	17	15	of	of	IN
cord-310268-8q4tk6fd	17	16	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	17	17	acid	acid	NN
cord-310268-8q4tk6fd	17	18	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	17	19	,	,	,
cord-310268-8q4tk6fd	17	20	particularly	particularly	RB
cord-310268-8q4tk6fd	17	21	RNA	RNA	NNP
cord-310268-8q4tk6fd	17	22	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	17	23	,	,	,
cord-310268-8q4tk6fd	17	24	as	as	IN
cord-310268-8q4tk6fd	17	25	therapeutic	therapeutic	JJ
cord-310268-8q4tk6fd	17	26	agents	agent	NNS
cord-310268-8q4tk6fd	17	27	,	,	,
cord-310268-8q4tk6fd	17	28	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	17	29	and	and	CC
cord-310268-8q4tk6fd	17	30	analytical	analytical	JJ
cord-310268-8q4tk6fd	17	31	tools	tool	NNS
cord-310268-8q4tk6fd	17	32	,	,	,
cord-310268-8q4tk6fd	17	33	vehicles	vehicle	NNS
cord-310268-8q4tk6fd	17	34	for	for	IN
cord-310268-8q4tk6fd	17	35	targeted	target	VBN
cord-310268-8q4tk6fd	17	36	drug	drug	NN
cord-310268-8q4tk6fd	17	37	delivery	delivery	NN
cord-310268-8q4tk6fd	17	38	,	,	,
cord-310268-8q4tk6fd	17	39	biosensors	biosensor	NNS
cord-310268-8q4tk6fd	17	40	and	and	CC
cord-310268-8q4tk6fd	17	41	even	even	RB
cord-310268-8q4tk6fd	17	42	genetic	genetic	JJ
cord-310268-8q4tk6fd	17	43	control	control	NN
cord-310268-8q4tk6fd	17	44	devices	device	NNS
cord-310268-8q4tk6fd	17	45	[	[	-LRB-
cord-310268-8q4tk6fd	17	46	5	5	CD
cord-310268-8q4tk6fd	17	47	,	,	,
cord-310268-8q4tk6fd	17	48	[	[	-LRB-
cord-310268-8q4tk6fd	17	49	8	8	CD
cord-310268-8q4tk6fd	17	50	]	]	-RRB-
cord-310268-8q4tk6fd	17	51	[	[	-LRB-
cord-310268-8q4tk6fd	17	52	9	9	CD
cord-310268-8q4tk6fd	17	53	]	]	-RRB-
cord-310268-8q4tk6fd	17	54	[	[	-LRB-
cord-310268-8q4tk6fd	17	55	10	10	CD
cord-310268-8q4tk6fd	17	56	]	]	-RRB-
cord-310268-8q4tk6fd	17	57	[	[	-LRB-
cord-310268-8q4tk6fd	17	58	11	11	CD
cord-310268-8q4tk6fd	17	59	]	]	-RRB-
cord-310268-8q4tk6fd	17	60	.	.	.
cord-310268-8q4tk6fd	18	1	Until	until	IN
cord-310268-8q4tk6fd	18	2	now	now	RB
cord-310268-8q4tk6fd	18	3	,	,	,
cord-310268-8q4tk6fd	18	4	although	although	IN
cord-310268-8q4tk6fd	18	5	only	only	RB
cord-310268-8q4tk6fd	18	6	one	one	CD
cord-310268-8q4tk6fd	18	7	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	18	8	(	(	-LRB-
cord-310268-8q4tk6fd	18	9	Macugen	Macugen	NNP
cord-310268-8q4tk6fd	18	10	,	,	,
cord-310268-8q4tk6fd	18	11	Pfizer	Pfizer	NNP
cord-310268-8q4tk6fd	18	12	/	/	SYM
cord-310268-8q4tk6fd	18	13	Eyetech	Eyetech	NNP
cord-310268-8q4tk6fd	18	14	)	)	-RRB-
cord-310268-8q4tk6fd	18	15	has	have	VBZ
cord-310268-8q4tk6fd	18	16	been	be	VBN
cord-310268-8q4tk6fd	18	17	approved	approve	VBN
cord-310268-8q4tk6fd	18	18	for	for	IN
cord-310268-8q4tk6fd	18	19	the	the	DT
cord-310268-8q4tk6fd	18	20	therapeutic	therapeutic	JJ
cord-310268-8q4tk6fd	18	21	use	use	NN
cord-310268-8q4tk6fd	18	22	in	in	IN
cord-310268-8q4tk6fd	18	23	the	the	DT
cord-310268-8q4tk6fd	18	24	clinic	clinic	NN
cord-310268-8q4tk6fd	18	25	[	[	-LRB-
cord-310268-8q4tk6fd	18	26	12	12	CD
cord-310268-8q4tk6fd	18	27	]	]	-RRB-
cord-310268-8q4tk6fd	18	28	,	,	,
cord-310268-8q4tk6fd	18	29	ten	ten	CD
cord-310268-8q4tk6fd	18	30	other	other	JJ
cord-310268-8q4tk6fd	18	31	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	18	32	are	be	VBP
cord-310268-8q4tk6fd	18	33	being	be	VBG
cord-310268-8q4tk6fd	18	34	evaluated	evaluate	VBN
cord-310268-8q4tk6fd	18	35	at	at	IN
cord-310268-8q4tk6fd	18	36	different	different	JJ
cord-310268-8q4tk6fd	18	37	stages	stage	NNS
cord-310268-8q4tk6fd	18	38	of	of	IN
cord-310268-8q4tk6fd	18	39	clinical	clinical	JJ
cord-310268-8q4tk6fd	18	40	trials	trial	NNS
cord-310268-8q4tk6fd	18	41	[	[	-LRB-
cord-310268-8q4tk6fd	18	42	5	5	CD
cord-310268-8q4tk6fd	18	43	,	,	,
cord-310268-8q4tk6fd	18	44	13	13	CD
cord-310268-8q4tk6fd	18	45	]	]	-RRB-
cord-310268-8q4tk6fd	18	46	.	.	.
cord-310268-8q4tk6fd	19	1	Currently	currently	RB
cord-310268-8q4tk6fd	19	2	,	,	,
cord-310268-8q4tk6fd	19	3	the	the	DT
cord-310268-8q4tk6fd	19	4	application	application	NN
cord-310268-8q4tk6fd	19	5	in	in	IN
cord-310268-8q4tk6fd	19	6	diagnostics	diagnostic	NNS
cord-310268-8q4tk6fd	19	7	,	,	,
cord-310268-8q4tk6fd	19	8	research	research	NN
cord-310268-8q4tk6fd	19	9	and	and	CC
cord-310268-8q4tk6fd	19	10	development	development	NN
cord-310268-8q4tk6fd	19	11	is	be	VBZ
cord-310268-8q4tk6fd	19	12	expected	expect	VBN
cord-310268-8q4tk6fd	19	13	to	to	TO
cord-310268-8q4tk6fd	19	14	account	account	VB
cord-310268-8q4tk6fd	19	15	for	for	IN
cord-310268-8q4tk6fd	19	16	the	the	DT
cord-310268-8q4tk6fd	19	17	largest	large	JJS
cord-310268-8q4tk6fd	19	18	share	share	NN
cord-310268-8q4tk6fd	19	19	of	of	IN
cord-310268-8q4tk6fd	19	20	the	the	DT
cord-310268-8q4tk6fd	19	21	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	19	22	market	market	NN
cord-310268-8q4tk6fd	19	23	.	.	.
cord-310268-8q4tk6fd	20	1	The	the	DT
cord-310268-8q4tk6fd	20	2	global	global	JJ
cord-310268-8q4tk6fd	20	3	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	20	4	market	market	NN
cord-310268-8q4tk6fd	20	5	was	be	VBD
cord-310268-8q4tk6fd	20	6	estimated	estimate	VBN
cord-310268-8q4tk6fd	20	7	to	to	TO
cord-310268-8q4tk6fd	20	8	be	be	VB
cord-310268-8q4tk6fd	20	9	valued	value	VBN
cord-310268-8q4tk6fd	20	10	at	at	IN
cord-310268-8q4tk6fd	20	11	$	$	$
cord-310268-8q4tk6fd	20	12	107.56	107.56	CD
cord-310268-8q4tk6fd	20	13	million	million	CD
cord-310268-8q4tk6fd	20	14	in	in	IN
cord-310268-8q4tk6fd	20	15	2015	2015	CD
cord-310268-8q4tk6fd	20	16	and	and	CC
cord-310268-8q4tk6fd	20	17	to	to	TO
cord-310268-8q4tk6fd	20	18	reach	reach	VB
cord-310268-8q4tk6fd	20	19	$	$	$
cord-310268-8q4tk6fd	20	20	244.93	244.93	CD
cord-310268-8q4tk6fd	20	21	million	million	CD
cord-310268-8q4tk6fd	20	22	by	by	IN
cord-310268-8q4tk6fd	20	23	2020	2020	CD
cord-310268-8q4tk6fd	20	24	[	[	-LRB-
cord-310268-8q4tk6fd	20	25	14	14	CD
cord-310268-8q4tk6fd	20	26	]	]	-RRB-
cord-310268-8q4tk6fd	20	27	.	.	.
cord-310268-8q4tk6fd	21	1	DNA	DNA	NNP
cord-310268-8q4tk6fd	21	2	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	21	3	are	be	VBP
cord-310268-8q4tk6fd	21	4	expected	expect	VBN
cord-310268-8q4tk6fd	21	5	to	to	TO
cord-310268-8q4tk6fd	21	6	account	account	VB
cord-310268-8q4tk6fd	21	7	for	for	IN
cord-310268-8q4tk6fd	21	8	the	the	DT
cord-310268-8q4tk6fd	21	9	largest	large	JJS
cord-310268-8q4tk6fd	21	10	share	share	NN
cord-310268-8q4tk6fd	21	11	of	of	IN
cord-310268-8q4tk6fd	21	12	the	the	DT
cord-310268-8q4tk6fd	21	13	global	global	JJ
cord-310268-8q4tk6fd	21	14	market	market	NN
cord-310268-8q4tk6fd	21	15	in	in	IN
cord-310268-8q4tk6fd	21	16	2015	2015	CD
cord-310268-8q4tk6fd	21	17	[	[	-LRB-
cord-310268-8q4tk6fd	21	18	14	14	CD
cord-310268-8q4tk6fd	21	19	]	]	-RRB-
cord-310268-8q4tk6fd	21	20	,	,	,
cord-310268-8q4tk6fd	21	21	which	which	WDT
cord-310268-8q4tk6fd	21	22	indicates	indicate	VBZ
cord-310268-8q4tk6fd	21	23	an	an	DT
cord-310268-8q4tk6fd	21	24	increase	increase	NN
cord-310268-8q4tk6fd	21	25	in	in	IN
cord-310268-8q4tk6fd	21	26	the	the	DT
cord-310268-8q4tk6fd	21	27	application	application	NN
cord-310268-8q4tk6fd	21	28	of	of	IN
cord-310268-8q4tk6fd	21	29	DNA	DNA	NNP
cord-310268-8q4tk6fd	21	30	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	21	31	.	.	.
cord-310268-8q4tk6fd	22	1	DNA	DNA	NNP
cord-310268-8q4tk6fd	22	2	and	and	CC
cord-310268-8q4tk6fd	22	3	RNA	RNA	NNP
cord-310268-8q4tk6fd	22	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	22	5	are	be	VBP
cord-310268-8q4tk6fd	22	6	functionally	functionally	RB
cord-310268-8q4tk6fd	22	7	similar	similar	JJ
cord-310268-8q4tk6fd	22	8	but	but	CC
cord-310268-8q4tk6fd	22	9	have	have	VBP
cord-310268-8q4tk6fd	22	10	some	some	DT
cord-310268-8q4tk6fd	22	11	differences	difference	NNS
cord-310268-8q4tk6fd	22	12	in	in	IN
cord-310268-8q4tk6fd	22	13	their	-PRON-	PRP$
cord-310268-8q4tk6fd	22	14	stability	stability	NN
cord-310268-8q4tk6fd	22	15	and	and	CC
cord-310268-8q4tk6fd	22	16	accessibility	accessibility	NN
cord-310268-8q4tk6fd	22	17	.	.	.
cord-310268-8q4tk6fd	23	1	Compared	compare	VBN
cord-310268-8q4tk6fd	23	2	with	with	IN
cord-310268-8q4tk6fd	23	3	DNA	dna	NN
cord-310268-8q4tk6fd	23	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	23	5	,	,	,
cord-310268-8q4tk6fd	23	6	RNA	RNA	NNP
cord-310268-8q4tk6fd	23	7	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	23	8	are	be	VBP
cord-310268-8q4tk6fd	23	9	chemically	chemically	RB
cord-310268-8q4tk6fd	23	10	unstable	unstable	JJ
cord-310268-8q4tk6fd	23	11	because	because	IN
cord-310268-8q4tk6fd	23	12	of	of	IN
cord-310268-8q4tk6fd	23	13	the	the	DT
cord-310268-8q4tk6fd	23	14	presence	presence	NN
cord-310268-8q4tk6fd	23	15	of	of	IN
cord-310268-8q4tk6fd	23	16	a	a	DT
cord-310268-8q4tk6fd	23	17	reactive	reactive	JJ
cord-310268-8q4tk6fd	23	18	hydroxyl	hydroxyl	NN
cord-310268-8q4tk6fd	23	19	group	group	NN
cord-310268-8q4tk6fd	23	20	(	(	-LRB-
cord-310268-8q4tk6fd	23	21	-OH	-oh	NN
cord-310268-8q4tk6fd	23	22	)	)	-RRB-
cord-310268-8q4tk6fd	23	23	at	at	IN
cord-310268-8q4tk6fd	23	24	the	the	DT
cord-310268-8q4tk6fd	23	25	2	2	CD
cord-310268-8q4tk6fd	23	26	1	1	CD
cord-310268-8q4tk6fd	23	27	position	position	NN
cord-310268-8q4tk6fd	23	28	of	of	IN
cord-310268-8q4tk6fd	23	29	the	the	DT
cord-310268-8q4tk6fd	23	30	ribose	ribose	NN
cord-310268-8q4tk6fd	23	31	sugar	sugar	NN
cord-310268-8q4tk6fd	23	32	in	in	IN
cord-310268-8q4tk6fd	23	33	RNA	RNA	NNP
cord-310268-8q4tk6fd	23	34	nucleotides	nucleotide	NNS
cord-310268-8q4tk6fd	23	35	.	.	.
cord-310268-8q4tk6fd	24	1	This	this	DT
cord-310268-8q4tk6fd	24	2	-OH	-oh	NN
cord-310268-8q4tk6fd	24	3	group	group	NN
cord-310268-8q4tk6fd	24	4	easily	easily	RB
cord-310268-8q4tk6fd	24	5	gets	get	VBZ
cord-310268-8q4tk6fd	24	6	deprotonated	deprotonated	JJ
cord-310268-8q4tk6fd	24	7	in	in	IN
cord-310268-8q4tk6fd	24	8	solution	solution	NN
cord-310268-8q4tk6fd	24	9	,	,	,
cord-310268-8q4tk6fd	24	10	especially	especially	RB
cord-310268-8q4tk6fd	24	11	in	in	IN
cord-310268-8q4tk6fd	24	12	alkaline	alkaline	JJ
cord-310268-8q4tk6fd	24	13	solutions	solution	NNS
cord-310268-8q4tk6fd	24	14	.	.	.
cord-310268-8q4tk6fd	25	1	The	the	DT
cord-310268-8q4tk6fd	25	2	resulting	result	VBG
cord-310268-8q4tk6fd	25	3	anionic	anionic	JJ
cord-310268-8q4tk6fd	25	4	2	2	CD
cord-310268-8q4tk6fd	25	5	1	1	CD
cord-310268-8q4tk6fd	25	6	-O´may	-O´may	:
cord-310268-8q4tk6fd	25	7	nucleophilically	nucleophilically	RB
cord-310268-8q4tk6fd	25	8	attack	attack	VB
cord-310268-8q4tk6fd	25	9	the	the	DT
cord-310268-8q4tk6fd	25	10	phosphorus	phosphorus	NN
cord-310268-8q4tk6fd	25	11	atom	atom	NN
cord-310268-8q4tk6fd	25	12	of	of	IN
cord-310268-8q4tk6fd	25	13	the	the	DT
cord-310268-8q4tk6fd	25	14	phosphodiester	phosphodiester	NN
cord-310268-8q4tk6fd	25	15	linkage	linkage	NN
cord-310268-8q4tk6fd	25	16	,	,	,
cord-310268-8q4tk6fd	25	17	leading	lead	VBG
cord-310268-8q4tk6fd	25	18	to	to	IN
cord-310268-8q4tk6fd	25	19	the	the	DT
cord-310268-8q4tk6fd	25	20	hydrolysis	hydrolysis	NN
cord-310268-8q4tk6fd	25	21	of	of	IN
cord-310268-8q4tk6fd	25	22	RNA	RNA	NNP
cord-310268-8q4tk6fd	25	23	molecules	molecule	NNS
cord-310268-8q4tk6fd	25	24	[	[	-LRB-
cord-310268-8q4tk6fd	25	25	15	15	CD
cord-310268-8q4tk6fd	25	26	]	]	-RRB-
cord-310268-8q4tk6fd	25	27	.	.	.
cord-310268-8q4tk6fd	26	1	The	the	DT
cord-310268-8q4tk6fd	26	2	nuclease	nuclease	NN
cord-310268-8q4tk6fd	26	3	resistance	resistance	NN
cord-310268-8q4tk6fd	26	4	of	of	IN
cord-310268-8q4tk6fd	26	5	RNA	RNA	NNP
cord-310268-8q4tk6fd	26	6	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	26	7	was	be	VBD
cord-310268-8q4tk6fd	26	8	found	find	VBN
cord-310268-8q4tk6fd	26	9	to	to	TO
cord-310268-8q4tk6fd	26	10	increase	increase	VB
cord-310268-8q4tk6fd	26	11	when	when	WRB
cord-310268-8q4tk6fd	26	12	the	the	DT
cord-310268-8q4tk6fd	26	13	2	2	CD
cord-310268-8q4tk6fd	26	14	1	1	CD
cord-310268-8q4tk6fd	26	15	-hydroxyl	-hydroxyl	CD
cord-310268-8q4tk6fd	26	16	group	group	NN
cord-310268-8q4tk6fd	26	17	was	be	VBD
cord-310268-8q4tk6fd	26	18	removed	remove	VBN
cord-310268-8q4tk6fd	26	19	from	from	IN
cord-310268-8q4tk6fd	26	20	the	the	DT
cord-310268-8q4tk6fd	26	21	sugars	sugar	NNS
cord-310268-8q4tk6fd	26	22	of	of	IN
cord-310268-8q4tk6fd	26	23	RNA	RNA	NNP
cord-310268-8q4tk6fd	26	24	[	[	-LRB-
cord-310268-8q4tk6fd	26	25	16	16	CD
cord-310268-8q4tk6fd	26	26	,	,	,
cord-310268-8q4tk6fd	26	27	17	17	CD
cord-310268-8q4tk6fd	26	28	]	]	-RRB-
cord-310268-8q4tk6fd	26	29	.	.	.
cord-310268-8q4tk6fd	27	1	DNA	DNA	NNP
cord-310268-8q4tk6fd	27	2	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	27	3	are	be	VBP
cord-310268-8q4tk6fd	27	4	less	less	RBR
cord-310268-8q4tk6fd	27	5	reactive	reactive	JJ
cord-310268-8q4tk6fd	27	6	and	and	CC
cord-310268-8q4tk6fd	27	7	relatively	relatively	RB
cord-310268-8q4tk6fd	27	8	stable	stable	JJ
cord-310268-8q4tk6fd	27	9	because	because	IN
cord-310268-8q4tk6fd	27	10	of	of	IN
cord-310268-8q4tk6fd	27	11	the	the	DT
cord-310268-8q4tk6fd	27	12	C	C	NNP
cord-310268-8q4tk6fd	27	13	-	-	HYPH
cord-310268-8q4tk6fd	27	14	H	H	NNP
cord-310268-8q4tk6fd	27	15	bonds	bond	NNS
cord-310268-8q4tk6fd	27	16	at	at	IN
cord-310268-8q4tk6fd	27	17	the	the	DT
cord-310268-8q4tk6fd	27	18	2	2	CD
cord-310268-8q4tk6fd	27	19	1	1	CD
cord-310268-8q4tk6fd	27	20	position	position	NN
cord-310268-8q4tk6fd	27	21	of	of	IN
cord-310268-8q4tk6fd	27	22	the	the	DT
cord-310268-8q4tk6fd	27	23	deoxyribose	deoxyribose	JJ
cord-310268-8q4tk6fd	27	24	sugar	sugar	NN
cord-310268-8q4tk6fd	27	25	of	of	IN
cord-310268-8q4tk6fd	27	26	DNA	dna	NN
cord-310268-8q4tk6fd	27	27	nucleotides	nucleotide	NNS
cord-310268-8q4tk6fd	27	28	.	.	.
cord-310268-8q4tk6fd	28	1	This	this	DT
cord-310268-8q4tk6fd	28	2	chemical	chemical	NN
cord-310268-8q4tk6fd	28	3	difference	difference	NN
cord-310268-8q4tk6fd	28	4	gives	give	VBZ
cord-310268-8q4tk6fd	28	5	DNA	dna	NN
cord-310268-8q4tk6fd	28	6	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	28	7	an	an	DT
cord-310268-8q4tk6fd	28	8	inherent	inherent	JJ
cord-310268-8q4tk6fd	28	9	advantage	advantage	NN
cord-310268-8q4tk6fd	28	10	in	in	IN
cord-310268-8q4tk6fd	28	11	stability	stability	NN
cord-310268-8q4tk6fd	28	12	over	over	IN
cord-310268-8q4tk6fd	28	13	RNA	RNA	NNP
cord-310268-8q4tk6fd	28	14	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	28	15	.	.	.
cord-310268-8q4tk6fd	29	1	Our	-PRON-	PRP$
cord-310268-8q4tk6fd	29	2	previous	previous	JJ
cord-310268-8q4tk6fd	29	3	study	study	NN
cord-310268-8q4tk6fd	29	4	also	also	RB
cord-310268-8q4tk6fd	29	5	confirmed	confirm	VBD
cord-310268-8q4tk6fd	29	6	that	that	IN
cord-310268-8q4tk6fd	29	7	DNA	DNA	NNP
cord-310268-8q4tk6fd	29	8	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	29	9	are	be	VBP
cord-310268-8q4tk6fd	29	10	much	much	RB
cord-310268-8q4tk6fd	29	11	more	more	RBR
cord-310268-8q4tk6fd	29	12	stable	stable	JJ
cord-310268-8q4tk6fd	29	13	than	than	IN
cord-310268-8q4tk6fd	29	14	natural	natural	JJ
cord-310268-8q4tk6fd	29	15	RNA	RNA	NNP
cord-310268-8q4tk6fd	29	16	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	29	17	in	in	IN
cord-310268-8q4tk6fd	29	18	10	10	CD
cord-310268-8q4tk6fd	29	19	%	%	NN
cord-310268-8q4tk6fd	29	20	fetal	fetal	JJ
cord-310268-8q4tk6fd	29	21	bovine	bovine	JJ
cord-310268-8q4tk6fd	29	22	serum	serum	NN
cord-310268-8q4tk6fd	29	23	(	(	-LRB-
cord-310268-8q4tk6fd	29	24	FBS	FBS	NNP
cord-310268-8q4tk6fd	29	25	)	)	-RRB-
cord-310268-8q4tk6fd	29	26	and	and	CC
cord-310268-8q4tk6fd	29	27	human	human	JJ
cord-310268-8q4tk6fd	29	28	serum	serum	NN
cord-310268-8q4tk6fd	29	29	[	[	-LRB-
cord-310268-8q4tk6fd	29	30	18	18	CD
cord-310268-8q4tk6fd	29	31	]	]	-RRB-
cord-310268-8q4tk6fd	29	32	.	.	.
cord-310268-8q4tk6fd	30	1	That	that	DT
cord-310268-8q4tk6fd	30	2	is	be	VBZ
cord-310268-8q4tk6fd	30	3	the	the	DT
cord-310268-8q4tk6fd	30	4	reason	reason	NN
cord-310268-8q4tk6fd	30	5	why	why	WRB
cord-310268-8q4tk6fd	30	6	extra	extra	JJ
cord-310268-8q4tk6fd	30	7	chemical	chemical	JJ
cord-310268-8q4tk6fd	30	8	modifications	modification	NNS
cord-310268-8q4tk6fd	30	9	are	be	VBP
cord-310268-8q4tk6fd	30	10	usually	usually	RB
cord-310268-8q4tk6fd	30	11	added	add	VBN
cord-310268-8q4tk6fd	30	12	to	to	IN
cord-310268-8q4tk6fd	30	13	RNA	RNA	NNP
cord-310268-8q4tk6fd	30	14	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	30	15	to	to	TO
cord-310268-8q4tk6fd	30	16	improve	improve	VB
cord-310268-8q4tk6fd	30	17	their	-PRON-	PRP$
cord-310268-8q4tk6fd	30	18	chemical	chemical	NN
cord-310268-8q4tk6fd	30	19	stability	stability	NN
cord-310268-8q4tk6fd	30	20	[	[	-LRB-
cord-310268-8q4tk6fd	30	21	19	19	CD
cord-310268-8q4tk6fd	30	22	]	]	-RRB-
cord-310268-8q4tk6fd	30	23	.	.	.
cord-310268-8q4tk6fd	31	1	However	however	RB
cord-310268-8q4tk6fd	31	2	,	,	,
cord-310268-8q4tk6fd	31	3	it	-PRON-	PRP
cord-310268-8q4tk6fd	31	4	should	should	MD
cord-310268-8q4tk6fd	31	5	be	be	VB
cord-310268-8q4tk6fd	31	6	noted	note	VBN
cord-310268-8q4tk6fd	31	7	that	that	IN
cord-310268-8q4tk6fd	31	8	the	the	DT
cord-310268-8q4tk6fd	31	9	reactivity	reactivity	NN
cord-310268-8q4tk6fd	31	10	of	of	IN
cord-310268-8q4tk6fd	31	11	RNA	RNA	NNP
cord-310268-8q4tk6fd	31	12	nucleotides	nucleotide	NNS
cord-310268-8q4tk6fd	31	13	and	and	CC
cord-310268-8q4tk6fd	31	14	non	non	JJ
cord-310268-8q4tk6fd	31	15	-	-	JJ
cord-310268-8q4tk6fd	31	16	Watson	Watson	NNP
cord-310268-8q4tk6fd	31	17	-	-	HYPH
cord-310268-8q4tk6fd	31	18	Crick	Crick	NNP
cord-310268-8q4tk6fd	31	19	base	base	NN
cord-310268-8q4tk6fd	31	20	pairing	pairing	NN
cord-310268-8q4tk6fd	31	21	makes	make	VBZ
cord-310268-8q4tk6fd	31	22	RNA	RNA	NNP
cord-310268-8q4tk6fd	31	23	oligonucleotides	oligonucleotide	NNS
cord-310268-8q4tk6fd	31	24	prone	prone	JJ
cord-310268-8q4tk6fd	31	25	to	to	IN
cord-310268-8q4tk6fd	31	26	forming	form	VBG
cord-310268-8q4tk6fd	31	27	more	more	RBR
cord-310268-8q4tk6fd	31	28	diverse	diverse	JJ
cord-310268-8q4tk6fd	31	29	and	and	CC
cord-310268-8q4tk6fd	31	30	complex	complex	JJ
cord-310268-8q4tk6fd	31	31	three	three	CD
cord-310268-8q4tk6fd	31	32	-	-	HYPH
cord-310268-8q4tk6fd	31	33	dimensional	dimensional	JJ
cord-310268-8q4tk6fd	31	34	(	(	-LRB-
cord-310268-8q4tk6fd	31	35	3D	3D	NNP
cord-310268-8q4tk6fd	31	36	)	)	-RRB-
cord-310268-8q4tk6fd	31	37	structures	structure	NNS
cord-310268-8q4tk6fd	31	38	[	[	-LRB-
cord-310268-8q4tk6fd	31	39	20	20	CD
cord-310268-8q4tk6fd	31	40	,	,	,
cord-310268-8q4tk6fd	31	41	21	21	CD
cord-310268-8q4tk6fd	31	42	]	]	-RRB-
cord-310268-8q4tk6fd	31	43	,	,	,
cord-310268-8q4tk6fd	31	44	which	which	WDT
cord-310268-8q4tk6fd	31	45	is	be	VBZ
cord-310268-8q4tk6fd	31	46	helpful	helpful	JJ
cord-310268-8q4tk6fd	31	47	for	for	IN
cord-310268-8q4tk6fd	31	48	selecting	select	VBG
cord-310268-8q4tk6fd	31	49	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	31	50	with	with	IN
cord-310268-8q4tk6fd	31	51	high	high	JJ
cord-310268-8q4tk6fd	31	52	affinity	affinity	NN
cord-310268-8q4tk6fd	31	53	and	and	CC
cord-310268-8q4tk6fd	31	54	specificity	specificity	NN
cord-310268-8q4tk6fd	31	55	from	from	IN
cord-310268-8q4tk6fd	31	56	RNA	RNA	NNP
cord-310268-8q4tk6fd	31	57	libraries	library	NNS
cord-310268-8q4tk6fd	31	58	[	[	-LRB-
cord-310268-8q4tk6fd	31	59	22	22	CD
cord-310268-8q4tk6fd	31	60	]	]	-RRB-
cord-310268-8q4tk6fd	31	61	.	.	.
cord-310268-8q4tk6fd	32	1	Therefore	therefore	RB
cord-310268-8q4tk6fd	32	2	,	,	,
cord-310268-8q4tk6fd	32	3	DNA	DNA	NNP
cord-310268-8q4tk6fd	32	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	32	5	are	be	VBP
cord-310268-8q4tk6fd	32	6	usually	usually	RB
cord-310268-8q4tk6fd	32	7	selected	select	VBN
cord-310268-8q4tk6fd	32	8	from	from	IN
cord-310268-8q4tk6fd	32	9	the	the	DT
cord-310268-8q4tk6fd	32	10	libraries	library	NNS
cord-310268-8q4tk6fd	32	11	containing	contain	VBG
cord-310268-8q4tk6fd	32	12	longer	long	RBR
cord-310268-8q4tk6fd	32	13	randomized	randomized	JJ
cord-310268-8q4tk6fd	32	14	regions	region	NNS
cord-310268-8q4tk6fd	32	15	for	for	IN
cord-310268-8q4tk6fd	32	16	the	the	DT
cord-310268-8q4tk6fd	32	17	purpose	purpose	NN
cord-310268-8q4tk6fd	32	18	of	of	IN
cord-310268-8q4tk6fd	32	19	obtaining	obtain	VBG
cord-310268-8q4tk6fd	32	20	more	more	RBR
cord-310268-8q4tk6fd	32	21	complicated	complicated	JJ
cord-310268-8q4tk6fd	32	22	structures	structure	NNS
cord-310268-8q4tk6fd	32	23	.	.	.
cord-310268-8q4tk6fd	33	1	Another	another	DT
cord-310268-8q4tk6fd	33	2	potential	potential	JJ
cord-310268-8q4tk6fd	33	3	advantage	advantage	NN
cord-310268-8q4tk6fd	33	4	of	of	IN
cord-310268-8q4tk6fd	33	5	DNA	dna	NN
cord-310268-8q4tk6fd	33	6	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	33	7	over	over	IN
cord-310268-8q4tk6fd	33	8	RNA	RNA	NNP
cord-310268-8q4tk6fd	33	9	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	33	10	is	be	VBZ
cord-310268-8q4tk6fd	33	11	their	-PRON-	PRP$
cord-310268-8q4tk6fd	33	12	relatively	relatively	RB
cord-310268-8q4tk6fd	33	13	simple	simple	JJ
cord-310268-8q4tk6fd	33	14	selection	selection	NN
cord-310268-8q4tk6fd	33	15	process	process	NN
cord-310268-8q4tk6fd	33	16	.	.	.
cord-310268-8q4tk6fd	34	1	The	the	DT
cord-310268-8q4tk6fd	34	2	selection	selection	NN
cord-310268-8q4tk6fd	34	3	of	of	IN
cord-310268-8q4tk6fd	34	4	RNA	RNA	NNP
cord-310268-8q4tk6fd	34	5	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	34	6	requires	require	VBZ
cord-310268-8q4tk6fd	34	7	reverse	reverse	JJ
cord-310268-8q4tk6fd	34	8	transcription	transcription	NN
cord-310268-8q4tk6fd	34	9	and	and	CC
cord-310268-8q4tk6fd	34	10	in	in	IN
cord-310268-8q4tk6fd	34	11	vitro	vitro	FW
cord-310268-8q4tk6fd	34	12	transcription	transcription	NN
cord-310268-8q4tk6fd	34	13	in	in	IN
cord-310268-8q4tk6fd	34	14	every	every	DT
cord-310268-8q4tk6fd	34	15	round	round	NN
cord-310268-8q4tk6fd	34	16	of	of	IN
cord-310268-8q4tk6fd	34	17	selection	selection	NN
cord-310268-8q4tk6fd	34	18	,	,	,
cord-310268-8q4tk6fd	34	19	as	as	RB
cord-310268-8q4tk6fd	34	20	well	well	RB
cord-310268-8q4tk6fd	34	21	as	as	IN
cord-310268-8q4tk6fd	34	22	an	an	DT
cord-310268-8q4tk6fd	34	23	initial	initial	JJ
cord-310268-8q4tk6fd	34	24	transcription	transcription	NN
cord-310268-8q4tk6fd	34	25	for	for	IN
cord-310268-8q4tk6fd	34	26	generating	generate	VBG
cord-310268-8q4tk6fd	34	27	the	the	DT
cord-310268-8q4tk6fd	34	28	RNA	RNA	NNP
cord-310268-8q4tk6fd	34	29	library	library	NN
cord-310268-8q4tk6fd	34	30	from	from	IN
cord-310268-8q4tk6fd	34	31	a	a	DT
cord-310268-8q4tk6fd	34	32	DNA	dna	NN
cord-310268-8q4tk6fd	34	33	library	library	NN
cord-310268-8q4tk6fd	34	34	in	in	IN
cord-310268-8q4tk6fd	34	35	most	most	JJS
cord-310268-8q4tk6fd	34	36	cases	case	NNS
cord-310268-8q4tk6fd	34	37	[	[	-LRB-
cord-310268-8q4tk6fd	34	38	1	1	CD
cord-310268-8q4tk6fd	34	39	,	,	,
cord-310268-8q4tk6fd	34	40	23	23	CD
cord-310268-8q4tk6fd	34	41	]	]	-RRB-
cord-310268-8q4tk6fd	34	42	.	.	.
cord-310268-8q4tk6fd	35	1	But	but	CC
cord-310268-8q4tk6fd	35	2	the	the	DT
cord-310268-8q4tk6fd	35	3	selection	selection	NN
cord-310268-8q4tk6fd	35	4	process	process	NN
cord-310268-8q4tk6fd	35	5	of	of	IN
cord-310268-8q4tk6fd	35	6	DNA	dna	NN
cord-310268-8q4tk6fd	35	7	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	35	8	does	do	VBZ
cord-310268-8q4tk6fd	35	9	not	not	RB
cord-310268-8q4tk6fd	35	10	require	require	VB
cord-310268-8q4tk6fd	35	11	these	these	DT
cord-310268-8q4tk6fd	35	12	extra	extra	JJ
cord-310268-8q4tk6fd	35	13	steps	step	NNS
cord-310268-8q4tk6fd	35	14	[	[	-LRB-
cord-310268-8q4tk6fd	35	15	4	4	CD
cord-310268-8q4tk6fd	35	16	,	,	,
cord-310268-8q4tk6fd	35	17	24	24	CD
cord-310268-8q4tk6fd	35	18	]	]	-RRB-
cord-310268-8q4tk6fd	35	19	.	.	.
cord-310268-8q4tk6fd	36	1	Moreover	moreover	RB
cord-310268-8q4tk6fd	36	2	,	,	,
cord-310268-8q4tk6fd	36	3	once	once	RB
cord-310268-8q4tk6fd	36	4	selected	select	VBN
cord-310268-8q4tk6fd	36	5	,	,	,
cord-310268-8q4tk6fd	36	6	the	the	DT
cord-310268-8q4tk6fd	36	7	cost	cost	NN
cord-310268-8q4tk6fd	36	8	of	of	IN
cord-310268-8q4tk6fd	36	9	producing	produce	VBG
cord-310268-8q4tk6fd	36	10	DNA	DNA	NNP
cord-310268-8q4tk6fd	36	11	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	36	12	is	be	VBZ
cord-310268-8q4tk6fd	36	13	lower	low	JJR
cord-310268-8q4tk6fd	36	14	than	than	IN
cord-310268-8q4tk6fd	36	15	that	that	DT
cord-310268-8q4tk6fd	36	16	for	for	IN
cord-310268-8q4tk6fd	36	17	RNA	RNA	NNP
cord-310268-8q4tk6fd	36	18	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	36	19	.	.	.
cord-310268-8q4tk6fd	37	1	Since	since	IN
cord-310268-8q4tk6fd	37	2	the	the	DT
cord-310268-8q4tk6fd	37	3	first	first	JJ
cord-310268-8q4tk6fd	37	4	ssDNA	ssdna	NN
cord-310268-8q4tk6fd	37	5	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	37	6	was	be	VBD
cord-310268-8q4tk6fd	37	7	selected	select	VBN
cord-310268-8q4tk6fd	37	8	for	for	IN
cord-310268-8q4tk6fd	37	9	human	human	JJ
cord-310268-8q4tk6fd	37	10	thrombin	thrombin	NN
cord-310268-8q4tk6fd	37	11	in	in	IN
cord-310268-8q4tk6fd	37	12	1992	1992	CD
cord-310268-8q4tk6fd	37	13	[	[	-LRB-
cord-310268-8q4tk6fd	37	14	4	4	CD
cord-310268-8q4tk6fd	37	15	]	]	-RRB-
cord-310268-8q4tk6fd	37	16	,	,	,
cord-310268-8q4tk6fd	37	17	DNA	DNA	NNP
cord-310268-8q4tk6fd	37	18	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	37	19	have	have	VBP
cord-310268-8q4tk6fd	37	20	been	be	VBN
cord-310268-8q4tk6fd	37	21	researched	research	VBN
cord-310268-8q4tk6fd	37	22	and	and	CC
cord-310268-8q4tk6fd	37	23	applied	apply	VBN
cord-310268-8q4tk6fd	37	24	in	in	IN
cord-310268-8q4tk6fd	37	25	various	various	JJ
cord-310268-8q4tk6fd	37	26	fields	field	NNS
cord-310268-8q4tk6fd	37	27	,	,	,
cord-310268-8q4tk6fd	37	28	especially	especially	RB
cord-310268-8q4tk6fd	37	29	in	in	IN
cord-310268-8q4tk6fd	37	30	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	37	31	and	and	CC
cord-310268-8q4tk6fd	37	32	treatment	treatment	NN
cord-310268-8q4tk6fd	37	33	of	of	IN
cord-310268-8q4tk6fd	37	34	human	human	JJ
cord-310268-8q4tk6fd	37	35	diseases	disease	NNS
cord-310268-8q4tk6fd	37	36	.	.	.
cord-310268-8q4tk6fd	38	1	DNA	DNA	NNP
cord-310268-8q4tk6fd	38	2	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	38	3	are	be	VBP
cord-310268-8q4tk6fd	38	4	usually	usually	RB
cord-310268-8q4tk6fd	38	5	explained	explain	VBN
cord-310268-8q4tk6fd	38	6	to	to	TO
cord-310268-8q4tk6fd	38	7	work	work	VB
cord-310268-8q4tk6fd	38	8	in	in	IN
cord-310268-8q4tk6fd	38	9	a	a	DT
cord-310268-8q4tk6fd	38	10	similar	similar	JJ
cord-310268-8q4tk6fd	38	11	way	way	NN
cord-310268-8q4tk6fd	38	12	to	to	IN
cord-310268-8q4tk6fd	38	13	RNA	RNA	NNP
cord-310268-8q4tk6fd	38	14	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	38	15	.	.	.
cord-310268-8q4tk6fd	39	1	Because	because	IN
cord-310268-8q4tk6fd	39	2	of	of	IN
cord-310268-8q4tk6fd	39	3	the	the	DT
cord-310268-8q4tk6fd	39	4	potential	potential	JJ
cord-310268-8q4tk6fd	39	5	advantages	advantage	NNS
cord-310268-8q4tk6fd	39	6	described	describe	VBN
cord-310268-8q4tk6fd	39	7	above	above	RB
cord-310268-8q4tk6fd	39	8	,	,	,
cord-310268-8q4tk6fd	39	9	DNA	DNA	NNP
cord-310268-8q4tk6fd	39	10	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	39	11	have	have	VBP
cord-310268-8q4tk6fd	39	12	gained	gain	VBN
cord-310268-8q4tk6fd	39	13	increasing	increase	VBG
cord-310268-8q4tk6fd	39	14	attention	attention	NN
cord-310268-8q4tk6fd	39	15	in	in	IN
cord-310268-8q4tk6fd	39	16	recent	recent	JJ
cord-310268-8q4tk6fd	39	17	years	year	NNS
cord-310268-8q4tk6fd	39	18	.	.	.
cord-310268-8q4tk6fd	40	1	However	however	RB
cord-310268-8q4tk6fd	40	2	,	,	,
cord-310268-8q4tk6fd	40	3	they	-PRON-	PRP
cord-310268-8q4tk6fd	40	4	have	have	VBP
cord-310268-8q4tk6fd	40	5	seldom	seldom	RB
cord-310268-8q4tk6fd	40	6	been	be	VBN
cord-310268-8q4tk6fd	40	7	reviewed	review	VBN
cord-310268-8q4tk6fd	40	8	systematically	systematically	RB
cord-310268-8q4tk6fd	40	9	and	and	CC
cord-310268-8q4tk6fd	40	10	independently	independently	RB
cord-310268-8q4tk6fd	40	11	.	.	.
cord-310268-8q4tk6fd	41	1	To	to	TO
cord-310268-8q4tk6fd	41	2	better	well	RBR
cord-310268-8q4tk6fd	41	3	understand	understand	VB
cord-310268-8q4tk6fd	41	4	the	the	DT
cord-310268-8q4tk6fd	41	5	unique	unique	JJ
cord-310268-8q4tk6fd	41	6	potential	potential	NN
cord-310268-8q4tk6fd	41	7	of	of	IN
cord-310268-8q4tk6fd	41	8	DNA	dna	NN
cord-310268-8q4tk6fd	41	9	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	41	10	,	,	,
cord-310268-8q4tk6fd	41	11	this	this	DT
cord-310268-8q4tk6fd	41	12	article	article	NN
cord-310268-8q4tk6fd	41	13	will	will	MD
cord-310268-8q4tk6fd	41	14	review	review	VB
cord-310268-8q4tk6fd	41	15	the	the	DT
cord-310268-8q4tk6fd	41	16	recent	recent	JJ
cord-310268-8q4tk6fd	41	17	progress	progress	NN
cord-310268-8q4tk6fd	41	18	of	of	IN
cord-310268-8q4tk6fd	41	19	DNA	dna	NN
cord-310268-8q4tk6fd	41	20	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	41	21	in	in	IN
cord-310268-8q4tk6fd	41	22	regard	regard	NN
cord-310268-8q4tk6fd	41	23	to	to	IN
cord-310268-8q4tk6fd	41	24	their	-PRON-	PRP$
cord-310268-8q4tk6fd	41	25	preparation	preparation	NN
cord-310268-8q4tk6fd	41	26	and	and	CC
cord-310268-8q4tk6fd	41	27	application	application	NN
cord-310268-8q4tk6fd	41	28	in	in	IN
cord-310268-8q4tk6fd	41	29	the	the	DT
cord-310268-8q4tk6fd	41	30	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	41	31	and	and	CC
cord-310268-8q4tk6fd	41	32	treatment	treatment	NN
cord-310268-8q4tk6fd	41	33	of	of	IN
cord-310268-8q4tk6fd	41	34	human	human	JJ
cord-310268-8q4tk6fd	41	35	diseases	disease	NNS
cord-310268-8q4tk6fd	41	36	.	.	.
cord-310268-8q4tk6fd	42	1	The	the	DT
cord-310268-8q4tk6fd	42	2	advantages	advantage	NNS
cord-310268-8q4tk6fd	42	3	and	and	CC
cord-310268-8q4tk6fd	42	4	remaining	remain	VBG
cord-310268-8q4tk6fd	42	5	challenges	challenge	NNS
cord-310268-8q4tk6fd	42	6	to	to	TO
cord-310268-8q4tk6fd	42	7	develop	develop	VB
cord-310268-8q4tk6fd	42	8	and	and	CC
cord-310268-8q4tk6fd	42	9	use	use	VB
cord-310268-8q4tk6fd	42	10	DNA	dna	NN
cord-310268-8q4tk6fd	42	11	-	-	HYPH
cord-310268-8q4tk6fd	42	12	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	42	13	-	-	HYPH
cord-310268-8q4tk6fd	42	14	based	base	VBN
cord-310268-8q4tk6fd	42	15	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	42	16	tools	tool	NNS
cord-310268-8q4tk6fd	42	17	and	and	CC
cord-310268-8q4tk6fd	42	18	therapeutics	therapeutic	NNS
cord-310268-8q4tk6fd	42	19	will	will	MD
cord-310268-8q4tk6fd	42	20	also	also	RB
cord-310268-8q4tk6fd	42	21	be	be	VB
cord-310268-8q4tk6fd	42	22	discussed	discuss	VBN
cord-310268-8q4tk6fd	42	23	.	.	.
cord-310268-8q4tk6fd	43	1	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	43	2	,	,	,
cord-310268-8q4tk6fd	43	3	an	an	DT
cord-310268-8q4tk6fd	43	4	interactive	interactive	NN
cord-310268-8q4tk6fd	43	5	in	in	IN
cord-310268-8q4tk6fd	43	6	vitro	vitro	FW
cord-310268-8q4tk6fd	43	7	selection	selection	NN
cord-310268-8q4tk6fd	43	8	procedure	procedure	NN
cord-310268-8q4tk6fd	43	9	,	,	,
cord-310268-8q4tk6fd	43	10	is	be	VBZ
cord-310268-8q4tk6fd	43	11	the	the	DT
cord-310268-8q4tk6fd	43	12	basic	basic	JJ
cord-310268-8q4tk6fd	43	13	method	method	NN
cord-310268-8q4tk6fd	43	14	used	use	VBN
cord-310268-8q4tk6fd	43	15	to	to	TO
cord-310268-8q4tk6fd	43	16	engineer	engineer	VB
cord-310268-8q4tk6fd	43	17	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	43	18	,	,	,
cord-310268-8q4tk6fd	43	19	which	which	WDT
cord-310268-8q4tk6fd	43	20	was	be	VBD
cord-310268-8q4tk6fd	43	21	first	first	RB
cord-310268-8q4tk6fd	43	22	reported	report	VBN
cord-310268-8q4tk6fd	43	23	for	for	IN
cord-310268-8q4tk6fd	43	24	screening	screening	NN
cord-310268-8q4tk6fd	43	25	of	of	IN
cord-310268-8q4tk6fd	43	26	RNA	RNA	NNP
cord-310268-8q4tk6fd	43	27	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	43	28	independently	independently	RB
cord-310268-8q4tk6fd	43	29	by	by	IN
cord-310268-8q4tk6fd	43	30	Ellington	Ellington	NNP
cord-310268-8q4tk6fd	43	31	's	's	POS
cord-310268-8q4tk6fd	43	32	and	and	CC
cord-310268-8q4tk6fd	43	33	Tuerk	Tuerk	NNP
cord-310268-8q4tk6fd	43	34	's	's	POS
cord-310268-8q4tk6fd	43	35	groups	group	NNS
cord-310268-8q4tk6fd	43	36	25	25	CD
cord-310268-8q4tk6fd	43	37	years	year	NNS
cord-310268-8q4tk6fd	43	38	ago	ago	RB
cord-310268-8q4tk6fd	43	39	[	[	-LRB-
cord-310268-8q4tk6fd	43	40	1	1	CD
cord-310268-8q4tk6fd	43	41	,	,	,
cord-310268-8q4tk6fd	43	42	2	2	CD
cord-310268-8q4tk6fd	43	43	]	]	-RRB-
cord-310268-8q4tk6fd	43	44	.	.	.
cord-310268-8q4tk6fd	44	1	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	44	2	was	be	VBD
cord-310268-8q4tk6fd	44	3	then	then	RB
cord-310268-8q4tk6fd	44	4	adapted	adapt	VBN
cord-310268-8q4tk6fd	44	5	to	to	TO
cord-310268-8q4tk6fd	44	6	generate	generate	VB
cord-310268-8q4tk6fd	44	7	DNA	DNA	NNP
cord-310268-8q4tk6fd	44	8	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	44	9	[	[	-LRB-
cord-310268-8q4tk6fd	44	10	3	3	CD
cord-310268-8q4tk6fd	44	11	,	,	,
cord-310268-8q4tk6fd	44	12	4	4	CD
cord-310268-8q4tk6fd	44	13	]	]	-RRB-
cord-310268-8q4tk6fd	44	14	.	.	.
cord-310268-8q4tk6fd	45	1	In	in	IN
cord-310268-8q4tk6fd	45	2	principle	principle	NN
cord-310268-8q4tk6fd	45	3	,	,	,
cord-310268-8q4tk6fd	45	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	45	5	are	be	VBP
cord-310268-8q4tk6fd	45	6	selected	select	VBN
cord-310268-8q4tk6fd	45	7	from	from	IN
cord-310268-8q4tk6fd	45	8	an	an	DT
cord-310268-8q4tk6fd	45	9	initial	initial	JJ
cord-310268-8q4tk6fd	45	10	random	random	JJ
cord-310268-8q4tk6fd	45	11	ssDNA	ssdna	JJ
cord-310268-8q4tk6fd	45	12	pool	pool	NN
cord-310268-8q4tk6fd	45	13	based	base	VBN
cord-310268-8q4tk6fd	45	14	on	on	IN
cord-310268-8q4tk6fd	45	15	the	the	DT
cord-310268-8q4tk6fd	45	16	binding	binding	NN
cord-310268-8q4tk6fd	45	17	of	of	IN
cord-310268-8q4tk6fd	45	18	the	the	DT
cord-310268-8q4tk6fd	45	19	oligonucleotides	oligonucleotide	NNS
cord-310268-8q4tk6fd	45	20	to	to	IN
cord-310268-8q4tk6fd	45	21	the	the	DT
cord-310268-8q4tk6fd	45	22	target	target	NN
cord-310268-8q4tk6fd	45	23	molecules	molecule	NNS
cord-310268-8q4tk6fd	45	24	under	under	IN
cord-310268-8q4tk6fd	45	25	optimal	optimal	JJ
cord-310268-8q4tk6fd	45	26	conditions	condition	NNS
cord-310268-8q4tk6fd	45	27	.	.	.
cord-310268-8q4tk6fd	46	1	The	the	DT
cord-310268-8q4tk6fd	46	2	ssDNA	ssdna	JJ
cord-310268-8q4tk6fd	46	3	pool	pool	NN
cord-310268-8q4tk6fd	46	4	contains	contain	VBZ
cord-310268-8q4tk6fd	46	5	10	10	CD
cord-310268-8q4tk6fd	46	6	14	14	CD
cord-310268-8q4tk6fd	46	7	-10	-10	SYM
cord-310268-8q4tk6fd	46	8	15	15	CD
cord-310268-8q4tk6fd	46	9	random	random	JJ
cord-310268-8q4tk6fd	46	10	sequences	sequence	NNS
cord-310268-8q4tk6fd	46	11	of	of	IN
cord-310268-8q4tk6fd	46	12	synthetic	synthetic	JJ
cord-310268-8q4tk6fd	46	13	DNA	dna	NN
cord-310268-8q4tk6fd	46	14	(	(	-LRB-
cord-310268-8q4tk6fd	46	15	the	the	DT
cord-310268-8q4tk6fd	46	16	typical	typical	JJ
cord-310268-8q4tk6fd	46	17	length	length	NN
cord-310268-8q4tk6fd	46	18	is	be	VBZ
cord-310268-8q4tk6fd	46	19	15	15	CD
cord-310268-8q4tk6fd	46	20	-	-	SYM
cord-310268-8q4tk6fd	46	21	70	70	CD
cord-310268-8q4tk6fd	46	22	nucleotides	nucleotide	NNS
cord-310268-8q4tk6fd	46	23	,	,	,
cord-310268-8q4tk6fd	46	24	flanked	flank	VBN
cord-310268-8q4tk6fd	46	25	by	by	IN
cord-310268-8q4tk6fd	46	26	two	two	CD
cord-310268-8q4tk6fd	46	27	constant	constant	JJ
cord-310268-8q4tk6fd	46	28	regions	region	NNS
cord-310268-8q4tk6fd	46	29	with	with	IN
cord-310268-8q4tk6fd	46	30	primer	primer	NN
cord-310268-8q4tk6fd	46	31	sites	site	NNS
cord-310268-8q4tk6fd	46	32	for	for	IN
cord-310268-8q4tk6fd	46	33	polymerase	polymerase	NN
cord-310268-8q4tk6fd	46	34	chain	chain	NN
cord-310268-8q4tk6fd	46	35	reaction	reaction	NN
cord-310268-8q4tk6fd	46	36	[	[	-LRB-
cord-310268-8q4tk6fd	46	37	PCR	PCR	NNP
cord-310268-8q4tk6fd	46	38	]	]	-RRB-
cord-310268-8q4tk6fd	46	39	amplification	amplification	NN
cord-310268-8q4tk6fd	46	40	)	)	-RRB-
cord-310268-8q4tk6fd	46	41	.	.	.
cord-310268-8q4tk6fd	47	1	The	the	DT
cord-310268-8q4tk6fd	47	2	unbound	unbound	JJ
cord-310268-8q4tk6fd	47	3	sequences	sequence	NNS
cord-310268-8q4tk6fd	47	4	are	be	VBP
cord-310268-8q4tk6fd	47	5	separated	separate	VBN
cord-310268-8q4tk6fd	47	6	from	from	IN
cord-310268-8q4tk6fd	47	7	the	the	DT
cord-310268-8q4tk6fd	47	8	bound	bind	VBN
cord-310268-8q4tk6fd	47	9	molecules	molecule	NNS
cord-310268-8q4tk6fd	47	10	,	,	,
cord-310268-8q4tk6fd	47	11	and	and	CC
cord-310268-8q4tk6fd	47	12	the	the	DT
cord-310268-8q4tk6fd	47	13	target	target	NN
cord-310268-8q4tk6fd	47	14	-	-	HYPH
cord-310268-8q4tk6fd	47	15	bound	bind	VBN
cord-310268-8q4tk6fd	47	16	sequences	sequence	NNS
cord-310268-8q4tk6fd	47	17	are	be	VBP
cord-310268-8q4tk6fd	47	18	amplified	amplify	VBN
cord-310268-8q4tk6fd	47	19	by	by	IN
cord-310268-8q4tk6fd	47	20	PCR	PCR	NNP
cord-310268-8q4tk6fd	47	21	.	.	.
cord-310268-8q4tk6fd	48	1	The	the	DT
cord-310268-8q4tk6fd	48	2	amplified	amplified	JJ
cord-310268-8q4tk6fd	48	3	products	product	NNS
cord-310268-8q4tk6fd	48	4	(	(	-LRB-
cord-310268-8q4tk6fd	48	5	double	double	RB
cord-310268-8q4tk6fd	48	6	stranded	strand	VBN
cord-310268-8q4tk6fd	48	7	DNA	DNA	NNP
cord-310268-8q4tk6fd	48	8	)	)	-RRB-
cord-310268-8q4tk6fd	48	9	are	be	VBP
cord-310268-8q4tk6fd	48	10	converted	convert	VBN
cord-310268-8q4tk6fd	48	11	to	to	IN
cord-310268-8q4tk6fd	48	12	ssDNA	ssdna	RB
cord-310268-8q4tk6fd	48	13	through	through	IN
cord-310268-8q4tk6fd	48	14	various	various	JJ
cord-310268-8q4tk6fd	48	15	ways	way	NNS
cord-310268-8q4tk6fd	48	16	[	[	-LRB-
cord-310268-8q4tk6fd	48	17	25	25	CD
cord-310268-8q4tk6fd	48	18	]	]	-RRB-
cord-310268-8q4tk6fd	48	19	and	and	CC
cord-310268-8q4tk6fd	48	20	then	then	RB
cord-310268-8q4tk6fd	48	21	used	use	VBN
cord-310268-8q4tk6fd	48	22	as	as	IN
cord-310268-8q4tk6fd	48	23	a	a	DT
cord-310268-8q4tk6fd	48	24	new	new	JJ
cord-310268-8q4tk6fd	48	25	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	48	26	pool	pool	NN
cord-310268-8q4tk6fd	48	27	for	for	IN
cord-310268-8q4tk6fd	48	28	the	the	DT
cord-310268-8q4tk6fd	48	29	next	next	JJ
cord-310268-8q4tk6fd	48	30	selection	selection	NN
cord-310268-8q4tk6fd	48	31	round	round	RB
cord-310268-8q4tk6fd	48	32	.	.	.
cord-310268-8q4tk6fd	49	1	Enriched	enriched	JJ
cord-310268-8q4tk6fd	49	2	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	49	3	sequences	sequence	NNS
cord-310268-8q4tk6fd	49	4	are	be	VBP
cord-310268-8q4tk6fd	49	5	finally	finally	RB
cord-310268-8q4tk6fd	49	6	cloned	clone	VBN
cord-310268-8q4tk6fd	49	7	and	and	CC
cord-310268-8q4tk6fd	49	8	identified	identify	VBN
cord-310268-8q4tk6fd	49	9	by	by	IN
cord-310268-8q4tk6fd	49	10	sequencing	sequence	VBG
cord-310268-8q4tk6fd	49	11	.	.	.
cord-310268-8q4tk6fd	50	1	Usually	usually	RB
cord-310268-8q4tk6fd	50	2	after	after	IN
cord-310268-8q4tk6fd	50	3	10	10	CD
cord-310268-8q4tk6fd	50	4	-	-	SYM
cord-310268-8q4tk6fd	50	5	20	20	CD
cord-310268-8q4tk6fd	50	6	rounds	round	NNS
cord-310268-8q4tk6fd	50	7	of	of	IN
cord-310268-8q4tk6fd	50	8	selection	selection	NN
cord-310268-8q4tk6fd	50	9	,	,	,
cord-310268-8q4tk6fd	50	10	the	the	DT
cord-310268-8q4tk6fd	50	11	specific	specific	JJ
cord-310268-8q4tk6fd	50	12	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	50	13	with	with	IN
cord-310268-8q4tk6fd	50	14	the	the	DT
cord-310268-8q4tk6fd	50	15	strongest	strong	JJS
cord-310268-8q4tk6fd	50	16	affinity	affinity	NN
cord-310268-8q4tk6fd	50	17	for	for	IN
cord-310268-8q4tk6fd	50	18	the	the	DT
cord-310268-8q4tk6fd	50	19	target	target	NN
cord-310268-8q4tk6fd	50	20	molecules	molecule	NNS
cord-310268-8q4tk6fd	50	21	are	be	VBP
cord-310268-8q4tk6fd	50	22	obtained	obtain	VBN
cord-310268-8q4tk6fd	50	23	.	.	.
cord-310268-8q4tk6fd	51	1	Selection	selection	NN
cord-310268-8q4tk6fd	51	2	of	of	IN
cord-310268-8q4tk6fd	51	3	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	51	4	using	use	VBG
cord-310268-8q4tk6fd	51	5	conventional	conventional	JJ
cord-310268-8q4tk6fd	51	6	in	in	IN
cord-310268-8q4tk6fd	51	7	vitro	vitro	FW
cord-310268-8q4tk6fd	51	8	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	51	9	requires	require	VBZ
cord-310268-8q4tk6fd	51	10	purified	purify	VBN
cord-310268-8q4tk6fd	51	11	and	and	CC
cord-310268-8q4tk6fd	51	12	soluble	soluble	JJ
cord-310268-8q4tk6fd	51	13	target	target	NN
cord-310268-8q4tk6fd	51	14	proteins	protein	NNS
cord-310268-8q4tk6fd	51	15	.	.	.
cord-310268-8q4tk6fd	52	1	The	the	DT
cord-310268-8q4tk6fd	52	2	processes	process	NNS
cord-310268-8q4tk6fd	52	3	used	use	VBN
cord-310268-8q4tk6fd	52	4	to	to	TO
cord-310268-8q4tk6fd	52	5	obtain	obtain	VB
cord-310268-8q4tk6fd	52	6	purified	purify	VBN
cord-310268-8q4tk6fd	52	7	protein	protein	NN
cord-310268-8q4tk6fd	52	8	targets	target	NNS
cord-310268-8q4tk6fd	52	9	are	be	VBP
cord-310268-8q4tk6fd	52	10	time	time	NN
cord-310268-8q4tk6fd	52	11	-	-	HYPH
cord-310268-8q4tk6fd	52	12	consuming	consume	VBG
cord-310268-8q4tk6fd	52	13	.	.	.
cord-310268-8q4tk6fd	53	1	Sometimes	sometimes	RB
cord-310268-8q4tk6fd	53	2	it	-PRON-	PRP
cord-310268-8q4tk6fd	53	3	is	be	VBZ
cord-310268-8q4tk6fd	53	4	difficult	difficult	JJ
cord-310268-8q4tk6fd	53	5	to	to	TO
cord-310268-8q4tk6fd	53	6	purify	purify	VB
cord-310268-8q4tk6fd	53	7	target	target	NN
cord-310268-8q4tk6fd	53	8	proteins	protein	NNS
cord-310268-8q4tk6fd	53	9	.	.	.
cord-310268-8q4tk6fd	54	1	Moreover	moreover	RB
cord-310268-8q4tk6fd	54	2	,	,	,
cord-310268-8q4tk6fd	54	3	sometimes	sometimes	RB
cord-310268-8q4tk6fd	54	4	the	the	DT
cord-310268-8q4tk6fd	54	5	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	54	6	selected	select	VBD
cord-310268-8q4tk6fd	54	7	using	use	VBG
cord-310268-8q4tk6fd	54	8	a	a	DT
cord-310268-8q4tk6fd	54	9	non	non	JJ
cord-310268-8q4tk6fd	54	10	-	-	JJ
cord-310268-8q4tk6fd	54	11	native	native	JJ
cord-310268-8q4tk6fd	54	12	protein	protein	NN
cord-310268-8q4tk6fd	54	13	do	do	VBP
cord-310268-8q4tk6fd	54	14	not	not	RB
cord-310268-8q4tk6fd	54	15	interact	interact	VB
cord-310268-8q4tk6fd	54	16	with	with	IN
cord-310268-8q4tk6fd	54	17	the	the	DT
cord-310268-8q4tk6fd	54	18	protein	protein	NN
cord-310268-8q4tk6fd	54	19	in	in	IN
cord-310268-8q4tk6fd	54	20	a	a	DT
cord-310268-8q4tk6fd	54	21	native	native	JJ
cord-310268-8q4tk6fd	54	22	conformation	conformation	NN
cord-310268-8q4tk6fd	54	23	.	.	.
cord-310268-8q4tk6fd	55	1	To	to	TO
cord-310268-8q4tk6fd	55	2	solve	solve	VB
cord-310268-8q4tk6fd	55	3	these	these	DT
cord-310268-8q4tk6fd	55	4	problems	problem	NNS
cord-310268-8q4tk6fd	55	5	,	,	,
cord-310268-8q4tk6fd	55	6	a	a	DT
cord-310268-8q4tk6fd	55	7	strategy	strategy	NN
cord-310268-8q4tk6fd	55	8	using	use	VBG
cord-310268-8q4tk6fd	55	9	whole	whole	JJ
cord-310268-8q4tk6fd	55	10	live	live	JJ
cord-310268-8q4tk6fd	55	11	cells	cell	NNS
cord-310268-8q4tk6fd	55	12	as	as	IN
cord-310268-8q4tk6fd	55	13	targets	target	NNS
cord-310268-8q4tk6fd	55	14	for	for	IN
cord-310268-8q4tk6fd	55	15	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	55	16	selection	selection	NN
cord-310268-8q4tk6fd	55	17	has	have	VBZ
cord-310268-8q4tk6fd	55	18	been	be	VBN
cord-310268-8q4tk6fd	55	19	developed	develop	VBN
cord-310268-8q4tk6fd	55	20	,	,	,
cord-310268-8q4tk6fd	55	21	which	which	WDT
cord-310268-8q4tk6fd	55	22	is	be	VBZ
cord-310268-8q4tk6fd	55	23	known	know	VBN
cord-310268-8q4tk6fd	55	24	as	as	IN
cord-310268-8q4tk6fd	55	25	cell	cell	NN
cord-310268-8q4tk6fd	55	26	-	-	HYPH
cord-310268-8q4tk6fd	55	27	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	55	28	.	.	.
cord-310268-8q4tk6fd	56	1	This	this	DT
cord-310268-8q4tk6fd	56	2	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	56	3	is	be	VBZ
cord-310268-8q4tk6fd	56	4	able	able	JJ
cord-310268-8q4tk6fd	56	5	to	to	TO
cord-310268-8q4tk6fd	56	6	generate	generate	VB
cord-310268-8q4tk6fd	56	7	DNA	DNA	NNP
cord-310268-8q4tk6fd	56	8	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	56	9	that	that	WDT
cord-310268-8q4tk6fd	56	10	recognize	recognize	VBP
cord-310268-8q4tk6fd	56	11	the	the	DT
cord-310268-8q4tk6fd	56	12	cell	cell	NN
cord-310268-8q4tk6fd	56	13	-	-	HYPH
cord-310268-8q4tk6fd	56	14	surface	surface	NN
cord-310268-8q4tk6fd	56	15	or	or	CC
cord-310268-8q4tk6fd	56	16	intracellular	intracellular	JJ
cord-310268-8q4tk6fd	56	17	target	target	NN
cord-310268-8q4tk6fd	56	18	protein	protein	NN
cord-310268-8q4tk6fd	56	19	in	in	IN
cord-310268-8q4tk6fd	56	20	their	-PRON-	PRP$
cord-310268-8q4tk6fd	56	21	native	native	JJ
cord-310268-8q4tk6fd	56	22	conformation	conformation	NN
cord-310268-8q4tk6fd	56	23	,	,	,
cord-310268-8q4tk6fd	56	24	which	which	WDT
cord-310268-8q4tk6fd	56	25	shows	show	VBZ
cord-310268-8q4tk6fd	56	26	great	great	JJ
cord-310268-8q4tk6fd	56	27	potential	potential	NN
cord-310268-8q4tk6fd	56	28	in	in	IN
cord-310268-8q4tk6fd	56	29	cell	cell	NN
cord-310268-8q4tk6fd	56	30	-	-	HYPH
cord-310268-8q4tk6fd	56	31	specific	specific	JJ
cord-310268-8q4tk6fd	56	32	therapeutics	therapeutic	NNS
cord-310268-8q4tk6fd	56	33	and	and	CC
cord-310268-8q4tk6fd	56	34	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	56	35	applications	application	NNS
cord-310268-8q4tk6fd	56	36	[	[	-LRB-
cord-310268-8q4tk6fd	56	37	26	26	CD
cord-310268-8q4tk6fd	56	38	]	]	-RRB-
cord-310268-8q4tk6fd	56	39	[	[	-LRB-
cord-310268-8q4tk6fd	56	40	27	27	CD
cord-310268-8q4tk6fd	56	41	]	]	-RRB-
cord-310268-8q4tk6fd	56	42	[	[	-LRB-
cord-310268-8q4tk6fd	56	43	28	28	CD
cord-310268-8q4tk6fd	56	44	]	]	-RRB-
cord-310268-8q4tk6fd	56	45	.	.	.
cord-310268-8q4tk6fd	57	1	This	this	DT
cord-310268-8q4tk6fd	57	2	method	method	NN
cord-310268-8q4tk6fd	57	3	first	first	RB
cord-310268-8q4tk6fd	57	4	selects	select	VBZ
cord-310268-8q4tk6fd	57	5	the	the	DT
cord-310268-8q4tk6fd	57	6	specific	specific	JJ
cord-310268-8q4tk6fd	57	7	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	57	8	that	that	WDT
cord-310268-8q4tk6fd	57	9	bind	bind	VBP
cord-310268-8q4tk6fd	57	10	to	to	IN
cord-310268-8q4tk6fd	57	11	the	the	DT
cord-310268-8q4tk6fd	57	12	target	target	NN
cord-310268-8q4tk6fd	57	13	cells	cell	NNS
cord-310268-8q4tk6fd	57	14	by	by	IN
cord-310268-8q4tk6fd	57	15	a	a	DT
cord-310268-8q4tk6fd	57	16	positive	positive	JJ
cord-310268-8q4tk6fd	57	17	selection	selection	NN
cord-310268-8q4tk6fd	57	18	step	step	NN
cord-310268-8q4tk6fd	57	19	,	,	,
cord-310268-8q4tk6fd	57	20	and	and	CC
cord-310268-8q4tk6fd	57	21	then	then	RB
cord-310268-8q4tk6fd	57	22	eliminates	eliminate	VBZ
cord-310268-8q4tk6fd	57	23	the	the	DT
cord-310268-8q4tk6fd	57	24	non	non	JJ
cord-310268-8q4tk6fd	57	25	-	-	JJ
cord-310268-8q4tk6fd	57	26	target	target	JJ
cord-310268-8q4tk6fd	57	27	cell	cell	NN
cord-310268-8q4tk6fd	57	28	-	-	HYPH
cord-310268-8q4tk6fd	57	29	specific	specific	JJ
cord-310268-8q4tk6fd	57	30	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	57	31	by	by	IN
cord-310268-8q4tk6fd	57	32	a	a	DT
cord-310268-8q4tk6fd	57	33	negative	negative	JJ
cord-310268-8q4tk6fd	57	34	selection	selection	NN
cord-310268-8q4tk6fd	57	35	step	step	NN
cord-310268-8q4tk6fd	57	36	using	use	VBG
cord-310268-8q4tk6fd	57	37	non	non	JJ
cord-310268-8q4tk6fd	57	38	-	-	JJ
cord-310268-8q4tk6fd	57	39	target	target	JJ
cord-310268-8q4tk6fd	57	40	cells	cell	NNS
cord-310268-8q4tk6fd	57	41	,	,	,
cord-310268-8q4tk6fd	57	42	followed	follow	VBN
cord-310268-8q4tk6fd	57	43	by	by	IN
cord-310268-8q4tk6fd	57	44	the	the	DT
cord-310268-8q4tk6fd	57	45	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	57	46	process	process	NN
cord-310268-8q4tk6fd	57	47	as	as	IN
cord-310268-8q4tk6fd	57	48	summarized	summarize	VBN
cord-310268-8q4tk6fd	57	49	in	in	IN
cord-310268-8q4tk6fd	57	50	Figure	Figure	NNP
cord-310268-8q4tk6fd	57	51	1A	1a	CD
cord-310268-8q4tk6fd	57	52	.	.	.
cord-310268-8q4tk6fd	58	1	Recently	recently	RB
cord-310268-8q4tk6fd	58	2	,	,	,
cord-310268-8q4tk6fd	58	3	modified	modify	VBN
cord-310268-8q4tk6fd	58	4	cell	cell	NN
cord-310268-8q4tk6fd	58	5	-	-	HYPH
cord-310268-8q4tk6fd	58	6	SELEX	selex	NN
cord-310268-8q4tk6fd	58	7	methods	method	NNS
cord-310268-8q4tk6fd	58	8	have	have	VBP
cord-310268-8q4tk6fd	58	9	been	be	VBN
cord-310268-8q4tk6fd	58	10	developed	develop	VBN
cord-310268-8q4tk6fd	58	11	to	to	TO
cord-310268-8q4tk6fd	58	12	select	select	VB
cord-310268-8q4tk6fd	58	13	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	58	14	targeting	target	VBG
cord-310268-8q4tk6fd	58	15	specific	specific	JJ
cord-310268-8q4tk6fd	58	16	cells	cell	NNS
cord-310268-8q4tk6fd	58	17	like	like	IN
cord-310268-8q4tk6fd	58	18	disease	disease	NN
cord-310268-8q4tk6fd	58	19	state	state	NN
cord-310268-8q4tk6fd	58	20	cells	cell	NNS
cord-310268-8q4tk6fd	58	21	and	and	CC
cord-310268-8q4tk6fd	58	22	metastatic	metastatic	JJ
cord-310268-8q4tk6fd	58	23	cells	cell	NNS
cord-310268-8q4tk6fd	58	24	.	.	.
cord-310268-8q4tk6fd	59	1	They	-PRON-	PRP
cord-310268-8q4tk6fd	59	2	are	be	VBP
cord-310268-8q4tk6fd	59	3	stimulus	stimulus	NN
cord-310268-8q4tk6fd	59	4	-	-	HYPH
cord-310268-8q4tk6fd	59	5	response	response	NN
cord-310268-8q4tk6fd	59	6	cell	cell	NN
cord-310268-8q4tk6fd	59	7	-	-	:
cord-310268-8q4tk6fd	59	8	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	59	9	[	[	-LRB-
cord-310268-8q4tk6fd	59	10	29	29	CD
cord-310268-8q4tk6fd	59	11	]	]	-RRB-
cord-310268-8q4tk6fd	59	12	and	and	CC
cord-310268-8q4tk6fd	59	13	metastatic	metastatic	JJ
cord-310268-8q4tk6fd	59	14	-	-	HYPH
cord-310268-8q4tk6fd	59	15	cell	cell	NN
cord-310268-8q4tk6fd	59	16	-	-	HYPH
cord-310268-8q4tk6fd	59	17	based	base	VBN
cord-310268-8q4tk6fd	59	18	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	59	19	[	[	-LRB-
cord-310268-8q4tk6fd	59	20	30	30	CD
cord-310268-8q4tk6fd	59	21	]	]	-RRB-
cord-310268-8q4tk6fd	59	22	.	.	.
cord-310268-8q4tk6fd	60	1	To	to	TO
cord-310268-8q4tk6fd	60	2	shorten	shorten	VB
cord-310268-8q4tk6fd	60	3	the	the	DT
cord-310268-8q4tk6fd	60	4	time	time	NN
cord-310268-8q4tk6fd	60	5	of	of	IN
cord-310268-8q4tk6fd	60	6	conventional	conventional	JJ
cord-310268-8q4tk6fd	60	7	cell	cell	NN
cord-310268-8q4tk6fd	60	8	-	-	:
cord-310268-8q4tk6fd	60	9	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	60	10	,	,	,
cord-310268-8q4tk6fd	60	11	a	a	DT
cord-310268-8q4tk6fd	60	12	two	two	CD
cord-310268-8q4tk6fd	60	13	-	-	HYPH
cord-310268-8q4tk6fd	60	14	step	step	NN
cord-310268-8q4tk6fd	60	15	stimulus	stimulus	NN
cord-310268-8q4tk6fd	60	16	-	-	HYPH
cord-310268-8q4tk6fd	60	17	response	response	NN
cord-310268-8q4tk6fd	60	18	cell	cell	NN
cord-310268-8q4tk6fd	60	19	-	-	HYPH
cord-310268-8q4tk6fd	60	20	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	60	21	method	method	NN
cord-310268-8q4tk6fd	60	22	has	have	VBZ
cord-310268-8q4tk6fd	60	23	been	be	VBN
cord-310268-8q4tk6fd	60	24	developed	develop	VBN
cord-310268-8q4tk6fd	60	25	,	,	,
cord-310268-8q4tk6fd	60	26	which	which	WDT
cord-310268-8q4tk6fd	60	27	utilizes	utilize	VBZ
cord-310268-8q4tk6fd	60	28	asymmetric	asymmetric	JJ
cord-310268-8q4tk6fd	60	29	PCR	PCR	NNP
cord-310268-8q4tk6fd	60	30	or	or	CC
cord-310268-8q4tk6fd	60	31	streptavidin	streptavidin	NN
cord-310268-8q4tk6fd	60	32	-	-	HYPH
cord-310268-8q4tk6fd	60	33	biotin	biotin	NN
cord-310268-8q4tk6fd	60	34	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	60	35	separation	separation	NN
cord-310268-8q4tk6fd	60	36	for	for	IN
cord-310268-8q4tk6fd	60	37	the	the	DT
cord-310268-8q4tk6fd	60	38	generation	generation	NN
cord-310268-8q4tk6fd	60	39	of	of	IN
cord-310268-8q4tk6fd	60	40	single	single	RB
cord-310268-8q4tk6fd	60	41	-	-	HYPH
cord-310268-8q4tk6fd	60	42	stranded	strand	VBN
cord-310268-8q4tk6fd	60	43	DNA	dna	NN
cord-310268-8q4tk6fd	60	44	to	to	TO
cord-310268-8q4tk6fd	60	45	reduce	reduce	VB
cord-310268-8q4tk6fd	60	46	the	the	DT
cord-310268-8q4tk6fd	60	47	selection	selection	NN
cord-310268-8q4tk6fd	60	48	cycle	cycle	NN
cord-310268-8q4tk6fd	60	49	to	to	IN
cord-310268-8q4tk6fd	60	50	two	two	CD
cord-310268-8q4tk6fd	60	51	steps	step	NNS
cord-310268-8q4tk6fd	60	52	[	[	-LRB-
cord-310268-8q4tk6fd	60	53	29	29	CD
cord-310268-8q4tk6fd	60	54	]	]	-RRB-
cord-310268-8q4tk6fd	60	55	.	.	.
cord-310268-8q4tk6fd	61	1	Competitive	competitive	JJ
cord-310268-8q4tk6fd	61	2	cell	cell	NN
cord-310268-8q4tk6fd	61	3	-	-	:
cord-310268-8q4tk6fd	61	4	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	61	5	is	be	VBZ
cord-310268-8q4tk6fd	61	6	another	another	DT
cord-310268-8q4tk6fd	61	7	approach	approach	NN
cord-310268-8q4tk6fd	61	8	to	to	TO
cord-310268-8q4tk6fd	61	9	improve	improve	VB
cord-310268-8q4tk6fd	61	10	selection	selection	NN
cord-310268-8q4tk6fd	61	11	efficiency	efficiency	NN
cord-310268-8q4tk6fd	61	12	and	and	CC
cord-310268-8q4tk6fd	61	13	affinity	affinity	NN
cord-310268-8q4tk6fd	61	14	,	,	,
cord-310268-8q4tk6fd	61	15	which	which	WDT
cord-310268-8q4tk6fd	61	16	utilizes	utilize	VBZ
cord-310268-8q4tk6fd	61	17	a	a	DT
cord-310268-8q4tk6fd	61	18	nitrocellulose	nitrocellulose	JJ
cord-310268-8q4tk6fd	61	19	membrane	membrane	NN
cord-310268-8q4tk6fd	61	20	that	that	WDT
cord-310268-8q4tk6fd	61	21	contains	contain	VBZ
cord-310268-8q4tk6fd	61	22	the	the	DT
cord-310268-8q4tk6fd	61	23	target	target	NN
cord-310268-8q4tk6fd	61	24	cells	cell	NNS
cord-310268-8q4tk6fd	61	25	and	and	CC
cord-310268-8q4tk6fd	61	26	negative	negative	JJ
cord-310268-8q4tk6fd	61	27	control	control	NN
cord-310268-8q4tk6fd	61	28	cells	cell	NNS
cord-310268-8q4tk6fd	61	29	to	to	TO
cord-310268-8q4tk6fd	61	30	select	select	VB
cord-310268-8q4tk6fd	61	31	target	target	NN
cord-310268-8q4tk6fd	61	32	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	61	33	[	[	-LRB-
cord-310268-8q4tk6fd	61	34	31	31	CD
cord-310268-8q4tk6fd	61	35	]	]	-RRB-
cord-310268-8q4tk6fd	61	36	.	.	.
cord-310268-8q4tk6fd	62	1	This	this	DT
cord-310268-8q4tk6fd	62	2	method	method	NN
cord-310268-8q4tk6fd	62	3	can	can	MD
cord-310268-8q4tk6fd	62	4	reduce	reduce	VB
cord-310268-8q4tk6fd	62	5	the	the	DT
cord-310268-8q4tk6fd	62	6	selection	selection	NN
cord-310268-8q4tk6fd	62	7	time	time	NN
cord-310268-8q4tk6fd	62	8	,	,	,
cord-310268-8q4tk6fd	62	9	since	since	IN
cord-310268-8q4tk6fd	62	10	the	the	DT
cord-310268-8q4tk6fd	62	11	negative	negative	JJ
cord-310268-8q4tk6fd	62	12	selection	selection	NN
cord-310268-8q4tk6fd	62	13	step	step	NN
cord-310268-8q4tk6fd	62	14	is	be	VBZ
cord-310268-8q4tk6fd	62	15	not	not	RB
cord-310268-8q4tk6fd	62	16	required	require	VBN
cord-310268-8q4tk6fd	62	17	.	.	.
cord-310268-8q4tk6fd	63	1	The	the	DT
cord-310268-8q4tk6fd	63	2	conventional	conventional	JJ
cord-310268-8q4tk6fd	63	3	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	63	4	procedure	procedure	NN
cord-310268-8q4tk6fd	63	5	is	be	VBZ
cord-310268-8q4tk6fd	63	6	time	time	NN
cord-310268-8q4tk6fd	63	7	-	-	HYPH
cord-310268-8q4tk6fd	63	8	consuming	consume	VBG
cord-310268-8q4tk6fd	63	9	and	and	CC
cord-310268-8q4tk6fd	63	10	requires	require	VBZ
cord-310268-8q4tk6fd	63	11	several	several	JJ
cord-310268-8q4tk6fd	63	12	steps	step	NNS
cord-310268-8q4tk6fd	63	13	to	to	TO
cord-310268-8q4tk6fd	63	14	obtain	obtain	VB
cord-310268-8q4tk6fd	63	15	a	a	DT
cord-310268-8q4tk6fd	63	16	specific	specific	JJ
cord-310268-8q4tk6fd	63	17	DNA	dna	NN
cord-310268-8q4tk6fd	63	18	aptamer	aptamer	NN
cord-310268-8q4tk6fd	63	19	.	.	.
cord-310268-8q4tk6fd	64	1	To	to	TO
cord-310268-8q4tk6fd	64	2	effectively	effectively	RB
cord-310268-8q4tk6fd	64	3	generate	generate	VB
cord-310268-8q4tk6fd	64	4	highly	highly	RB
cord-310268-8q4tk6fd	64	5	specific	specific	JJ
cord-310268-8q4tk6fd	64	6	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	64	7	,	,	,
cord-310268-8q4tk6fd	64	8	several	several	JJ
cord-310268-8q4tk6fd	64	9	novel	novel	JJ
cord-310268-8q4tk6fd	64	10	methods	method	NNS
cord-310268-8q4tk6fd	64	11	using	use	VBG
cord-310268-8q4tk6fd	64	12	different	different	JJ
cord-310268-8q4tk6fd	64	13	selection	selection	NN
cord-310268-8q4tk6fd	64	14	approaches	approach	NNS
cord-310268-8q4tk6fd	64	15	have	have	VBP
cord-310268-8q4tk6fd	64	16	been	be	VBN
cord-310268-8q4tk6fd	64	17	developed	develop	VBN
cord-310268-8q4tk6fd	64	18	.	.	.
cord-310268-8q4tk6fd	65	1	Combining	combine	VBG
cord-310268-8q4tk6fd	65	2	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	65	3	with	with	IN
cord-310268-8q4tk6fd	65	4	other	other	JJ
cord-310268-8q4tk6fd	65	5	method	method	NN
cord-310268-8q4tk6fd	65	6	is	be	VBZ
cord-310268-8q4tk6fd	65	7	one	one	CD
cord-310268-8q4tk6fd	65	8	of	of	IN
cord-310268-8q4tk6fd	65	9	the	the	DT
cord-310268-8q4tk6fd	65	10	most	most	RBS
cord-310268-8q4tk6fd	65	11	effective	effective	JJ
cord-310268-8q4tk6fd	65	12	ways	way	NNS
cord-310268-8q4tk6fd	65	13	to	to	TO
cord-310268-8q4tk6fd	65	14	further	further	RB
cord-310268-8q4tk6fd	65	15	improve	improve	VB
cord-310268-8q4tk6fd	65	16	the	the	DT
cord-310268-8q4tk6fd	65	17	selection	selection	NN
cord-310268-8q4tk6fd	65	18	efficiency	efficiency	NN
cord-310268-8q4tk6fd	65	19	and	and	CC
cord-310268-8q4tk6fd	65	20	binding	bind	VBG
cord-310268-8q4tk6fd	65	21	affinity	affinity	NN
cord-310268-8q4tk6fd	65	22	of	of	IN
cord-310268-8q4tk6fd	65	23	DNA	dna	NN
cord-310268-8q4tk6fd	65	24	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	65	25	.	.	.
cord-310268-8q4tk6fd	66	1	For	for	IN
cord-310268-8q4tk6fd	66	2	example	example	NN
cord-310268-8q4tk6fd	66	3	,	,	,
cord-310268-8q4tk6fd	66	4	cell	cell	NN
cord-310268-8q4tk6fd	66	5	-	-	HYPH
cord-310268-8q4tk6fd	66	6	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	66	7	coupled	couple	VBN
cord-310268-8q4tk6fd	66	8	with	with	IN
cord-310268-8q4tk6fd	66	9	in	in	IN
cord-310268-8q4tk6fd	66	10	silico	silico	NN
cord-310268-8q4tk6fd	66	11	maturation	maturation	NN
cord-310268-8q4tk6fd	66	12	was	be	VBD
cord-310268-8q4tk6fd	66	13	developed	develop	VBN
cord-310268-8q4tk6fd	66	14	to	to	TO
cord-310268-8q4tk6fd	66	15	improve	improve	VB
cord-310268-8q4tk6fd	66	16	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	66	17	specificity	specificity	NN
cord-310268-8q4tk6fd	66	18	[	[	-LRB-
cord-310268-8q4tk6fd	66	19	31	31	CD
cord-310268-8q4tk6fd	66	20	]	]	-RRB-
cord-310268-8q4tk6fd	66	21	.	.	.
cord-310268-8q4tk6fd	67	1	The	the	DT
cord-310268-8q4tk6fd	67	2	method	method	NN
cord-310268-8q4tk6fd	67	3	consists	consist	VBZ
cord-310268-8q4tk6fd	67	4	of	of	IN
cord-310268-8q4tk6fd	67	5	cell	cell	NN
cord-310268-8q4tk6fd	67	6	-	-	HYPH
cord-310268-8q4tk6fd	67	7	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	67	8	,	,	,
cord-310268-8q4tk6fd	67	9	a	a	DT
cord-310268-8q4tk6fd	67	10	post	post	NN
cord-310268-8q4tk6fd	67	11	-	-	JJ
cord-310268-8q4tk6fd	67	12	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	67	13	in	in	IN
cord-310268-8q4tk6fd	67	14	silico	silico	NN
cord-310268-8q4tk6fd	67	15	process	process	NN
cord-310268-8q4tk6fd	67	16	and	and	CC
cord-310268-8q4tk6fd	67	17	in	in	IN
cord-310268-8q4tk6fd	67	18	vitro	vitro	FW
cord-310268-8q4tk6fd	67	19	screening	screening	NN
cord-310268-8q4tk6fd	67	20	.	.	.
cord-310268-8q4tk6fd	68	1	After	after	IN
cord-310268-8q4tk6fd	68	2	the	the	DT
cord-310268-8q4tk6fd	68	3	normal	normal	JJ
cord-310268-8q4tk6fd	68	4	cell	cell	NN
cord-310268-8q4tk6fd	68	5	-	-	:
cord-310268-8q4tk6fd	68	6	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	68	7	,	,	,
cord-310268-8q4tk6fd	68	8	an	an	DT
cord-310268-8q4tk6fd	68	9	extra	extra	JJ
cord-310268-8q4tk6fd	68	10	in	in	IN
cord-310268-8q4tk6fd	68	11	silico	silico	NN
cord-310268-8q4tk6fd	68	12	process	process	NN
cord-310268-8q4tk6fd	68	13	was	be	VBD
cord-310268-8q4tk6fd	68	14	performed	perform	VBN
cord-310268-8q4tk6fd	68	15	to	to	TO
cord-310268-8q4tk6fd	68	16	further	further	RB
cord-310268-8q4tk6fd	68	17	evolve	evolve	VB
cord-310268-8q4tk6fd	68	18	improved	improve	VBN
cord-310268-8q4tk6fd	68	19	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	68	20	from	from	IN
cord-310268-8q4tk6fd	68	21	the	the	DT
cord-310268-8q4tk6fd	68	22	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	68	23	-	-	HYPH
cord-310268-8q4tk6fd	68	24	selected	select	VBN
cord-310268-8q4tk6fd	68	25	sequences	sequence	NNS
cord-310268-8q4tk6fd	68	26	through	through	IN
cord-310268-8q4tk6fd	68	27	successive	successive	JJ
cord-310268-8q4tk6fd	68	28	rounds	round	NNS
cord-310268-8q4tk6fd	68	29	of	of	IN
cord-310268-8q4tk6fd	68	30	sequence	sequence	NN
cord-310268-8q4tk6fd	68	31	shuffling	shuffling	NN
cord-310268-8q4tk6fd	68	32	and	and	CC
cord-310268-8q4tk6fd	68	33	random	random	JJ
cord-310268-8q4tk6fd	68	34	mutation	mutation	NN
cord-310268-8q4tk6fd	68	35	based	base	VBN
cord-310268-8q4tk6fd	68	36	on	on	IN
cord-310268-8q4tk6fd	68	37	a	a	DT
cord-310268-8q4tk6fd	68	38	genetic	genetic	JJ
cord-310268-8q4tk6fd	68	39	algorithm	algorithm	NN
cord-310268-8q4tk6fd	68	40	.	.	.
cord-310268-8q4tk6fd	69	1	This	this	DT
cord-310268-8q4tk6fd	69	2	is	be	VBZ
cord-310268-8q4tk6fd	69	3	followed	follow	VBN
cord-310268-8q4tk6fd	69	4	by	by	IN
cord-310268-8q4tk6fd	69	5	in	in	FW
cord-310268-8q4tk6fd	69	6	vitro	vitro	FW
cord-310268-8q4tk6fd	69	7	functional	functional	JJ
cord-310268-8q4tk6fd	69	8	screening	screening	NN
cord-310268-8q4tk6fd	69	9	and	and	CC
cord-310268-8q4tk6fd	69	10	selection	selection	NN
cord-310268-8q4tk6fd	69	11	of	of	IN
cord-310268-8q4tk6fd	69	12	enhanced	enhanced	JJ
cord-310268-8q4tk6fd	69	13	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	69	14	from	from	IN
cord-310268-8q4tk6fd	69	15	the	the	DT
cord-310268-8q4tk6fd	69	16	shuffling	shuffling	NN
cord-310268-8q4tk6fd	69	17	and	and	CC
cord-310268-8q4tk6fd	69	18	mutated	mutated	JJ
cord-310268-8q4tk6fd	69	19	sequences	sequence	NNS
cord-310268-8q4tk6fd	69	20	.	.	.
cord-310268-8q4tk6fd	70	1	This	this	DT
cord-310268-8q4tk6fd	70	2	method	method	NN
cord-310268-8q4tk6fd	70	3	permits	permit	VBZ
cord-310268-8q4tk6fd	70	4	the	the	DT
cord-310268-8q4tk6fd	70	5	evolution	evolution	NN
cord-310268-8q4tk6fd	70	6	of	of	IN
cord-310268-8q4tk6fd	70	7	functionally	functionally	RB
cord-310268-8q4tk6fd	70	8	enhanced	enhance	VBN
cord-310268-8q4tk6fd	70	9	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	70	10	sequences	sequence	NNS
cord-310268-8q4tk6fd	70	11	recognizing	recognize	VBG
cord-310268-8q4tk6fd	70	12	targets	target	NNS
cord-310268-8q4tk6fd	70	13	of	of	IN
cord-310268-8q4tk6fd	70	14	interest	interest	NN
cord-310268-8q4tk6fd	70	15	.	.	.
cord-310268-8q4tk6fd	71	1	In	in	IN
cord-310268-8q4tk6fd	71	2	addition	addition	NN
cord-310268-8q4tk6fd	71	3	to	to	IN
cord-310268-8q4tk6fd	71	4	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	71	5	-	-	HYPH
cord-310268-8q4tk6fd	71	6	like	like	JJ
cord-310268-8q4tk6fd	71	7	methods	method	NNS
cord-310268-8q4tk6fd	71	8	,	,	,
cord-310268-8q4tk6fd	71	9	other	other	JJ
cord-310268-8q4tk6fd	71	10	methods	method	NNS
cord-310268-8q4tk6fd	71	11	have	have	VBP
cord-310268-8q4tk6fd	71	12	also	also	RB
cord-310268-8q4tk6fd	71	13	been	be	VBN
cord-310268-8q4tk6fd	71	14	developed	develop	VBN
cord-310268-8q4tk6fd	72	1	;	;	:
cord-310268-8q4tk6fd	72	2	magnetic	magnetic	RB
cord-310268-8q4tk6fd	72	3	-	-	HYPH
cord-310268-8q4tk6fd	72	4	assisted	assisted	JJ
cord-310268-8q4tk6fd	72	5	rapid	rapid	JJ
cord-310268-8q4tk6fd	72	6	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	72	7	selection	selection	NN
cord-310268-8q4tk6fd	72	8	(	(	-LRB-
cord-310268-8q4tk6fd	72	9	MARAS	MARAS	NNP
cord-310268-8q4tk6fd	72	10	)	)	-RRB-
cord-310268-8q4tk6fd	72	11	is	be	VBZ
cord-310268-8q4tk6fd	72	12	a	a	DT
cord-310268-8q4tk6fd	72	13	method	method	NN
cord-310268-8q4tk6fd	72	14	that	that	WDT
cord-310268-8q4tk6fd	72	15	uses	use	VBZ
cord-310268-8q4tk6fd	72	16	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	72	17	beads	bead	NNS
cord-310268-8q4tk6fd	72	18	and	and	CC
cord-310268-8q4tk6fd	72	19	an	an	DT
cord-310268-8q4tk6fd	72	20	externally	externally	RB
cord-310268-8q4tk6fd	72	21	applied	apply	VBN
cord-310268-8q4tk6fd	72	22	rotating	rotate	VBG
cord-310268-8q4tk6fd	72	23	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	72	24	field	field	NN
cord-310268-8q4tk6fd	72	25	to	to	TO
cord-310268-8q4tk6fd	72	26	provide	provide	VB
cord-310268-8q4tk6fd	72	27	the	the	DT
cord-310268-8q4tk6fd	72	28	competitive	competitive	JJ
cord-310268-8q4tk6fd	72	29	mechanism	mechanism	NN
cord-310268-8q4tk6fd	72	30	for	for	IN
cord-310268-8q4tk6fd	72	31	the	the	DT
cord-310268-8q4tk6fd	72	32	rapid	rapid	JJ
cord-310268-8q4tk6fd	72	33	selection	selection	NN
cord-310268-8q4tk6fd	72	34	of	of	IN
cord-310268-8q4tk6fd	72	35	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	72	36	with	with	IN
cord-310268-8q4tk6fd	72	37	different	different	JJ
cord-310268-8q4tk6fd	72	38	affinity	affinity	NN
cord-310268-8q4tk6fd	72	39	to	to	IN
cord-310268-8q4tk6fd	72	40	the	the	DT
cord-310268-8q4tk6fd	72	41	molecular	molecular	JJ
cord-310268-8q4tk6fd	72	42	target	target	NN
cord-310268-8q4tk6fd	72	43	as	as	IN
cord-310268-8q4tk6fd	72	44	summarized	summarize	VBN
cord-310268-8q4tk6fd	72	45	in	in	IN
cord-310268-8q4tk6fd	72	46	Figure	figure	NN
cord-310268-8q4tk6fd	72	47	1B	1b	CD
cord-310268-8q4tk6fd	72	48	[	[	-LRB-
cord-310268-8q4tk6fd	72	49	32	32	CD
cord-310268-8q4tk6fd	72	50	,	,	,
cord-310268-8q4tk6fd	72	51	33	33	CD
cord-310268-8q4tk6fd	72	52	]	]	-RRB-
cord-310268-8q4tk6fd	72	53	.	.	.
cord-310268-8q4tk6fd	73	1	This	this	DT
cord-310268-8q4tk6fd	73	2	method	method	NN
cord-310268-8q4tk6fd	73	3	uses	use	VBZ
cord-310268-8q4tk6fd	73	4	biofunctionalized	biofunctionalize	VBN
cord-310268-8q4tk6fd	73	5	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	73	6	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	73	7	to	to	TO
cord-310268-8q4tk6fd	73	8	separate	separate	VB
cord-310268-8q4tk6fd	73	9	target	target	NN
cord-310268-8q4tk6fd	73	10	-	-	HYPH
cord-310268-8q4tk6fd	73	11	bound	bind	VBN
cord-310268-8q4tk6fd	73	12	DNA	dna	NN
cord-310268-8q4tk6fd	73	13	oligonucleotides	oligonucleotide	NNS
cord-310268-8q4tk6fd	73	14	from	from	IN
cord-310268-8q4tk6fd	73	15	a	a	DT
cord-310268-8q4tk6fd	73	16	library	library	NN
cord-310268-8q4tk6fd	73	17	,	,	,
cord-310268-8q4tk6fd	73	18	selecting	select	VBG
cord-310268-8q4tk6fd	73	19	those	those	DT
cord-310268-8q4tk6fd	73	20	interactions	interaction	NNS
cord-310268-8q4tk6fd	73	21	that	that	WDT
cord-310268-8q4tk6fd	73	22	survive	survive	VBP
cord-310268-8q4tk6fd	73	23	a	a	DT
cord-310268-8q4tk6fd	73	24	disruptive	disruptive	JJ
cord-310268-8q4tk6fd	73	25	force	force	NN
cord-310268-8q4tk6fd	73	26	generated	generate	VBN
cord-310268-8q4tk6fd	73	27	by	by	IN
cord-310268-8q4tk6fd	73	28	the	the	DT
cord-310268-8q4tk6fd	73	29	movement	movement	NN
cord-310268-8q4tk6fd	73	30	of	of	IN
cord-310268-8q4tk6fd	73	31	the	the	DT
cord-310268-8q4tk6fd	73	32	particles	particle	NNS
cord-310268-8q4tk6fd	73	33	in	in	IN
cord-310268-8q4tk6fd	73	34	an	an	DT
cord-310268-8q4tk6fd	73	35	externally	externally	RB
cord-310268-8q4tk6fd	73	36	applied	apply	VBN
cord-310268-8q4tk6fd	73	37	rotating	rotate	VBG
cord-310268-8q4tk6fd	73	38	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	73	39	field	field	NN
cord-310268-8q4tk6fd	73	40	.	.	.
cord-310268-8q4tk6fd	74	1	It	-PRON-	PRP
cord-310268-8q4tk6fd	74	2	abandons	abandon	VBZ
cord-310268-8q4tk6fd	74	3	the	the	DT
cord-310268-8q4tk6fd	74	4	multi	multi	JJ
cord-310268-8q4tk6fd	74	5	-	-	JJ
cord-310268-8q4tk6fd	74	6	cycle	cycle	JJ
cord-310268-8q4tk6fd	74	7	evolutionary	evolutionary	JJ
cord-310268-8q4tk6fd	74	8	process	process	NN
cord-310268-8q4tk6fd	74	9	used	use	VBN
cord-310268-8q4tk6fd	74	10	in	in	IN
cord-310268-8q4tk6fd	74	11	conventional	conventional	JJ
cord-310268-8q4tk6fd	74	12	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	74	13	and	and	CC
cord-310268-8q4tk6fd	74	14	thus	thus	RB
cord-310268-8q4tk6fd	74	15	can	can	MD
cord-310268-8q4tk6fd	74	16	achieve	achieve	VB
cord-310268-8q4tk6fd	74	17	rapid	rapid	JJ
cord-310268-8q4tk6fd	74	18	selection	selection	NN
cord-310268-8q4tk6fd	74	19	(	(	-LRB-
cord-310268-8q4tk6fd	74	20	completed	complete	VBN
cord-310268-8q4tk6fd	74	21	in	in	IN
cord-310268-8q4tk6fd	74	22	less	less	JJR
cord-310268-8q4tk6fd	74	23	than	than	IN
cord-310268-8q4tk6fd	74	24	one	one	CD
cord-310268-8q4tk6fd	74	25	hour	hour	NN
cord-310268-8q4tk6fd	74	26	)	)	-RRB-
cord-310268-8q4tk6fd	74	27	.	.	.
cord-310268-8q4tk6fd	75	1	A	a	DT
cord-310268-8q4tk6fd	75	2	one	one	CD
cord-310268-8q4tk6fd	75	3	-	-	HYPH
cord-310268-8q4tk6fd	75	4	step	step	NN
cord-310268-8q4tk6fd	75	5	selection	selection	NN
cord-310268-8q4tk6fd	75	6	approach	approach	NN
cord-310268-8q4tk6fd	75	7	is	be	VBZ
cord-310268-8q4tk6fd	75	8	another	another	DT
cord-310268-8q4tk6fd	75	9	promising	promising	JJ
cord-310268-8q4tk6fd	75	10	way	way	NN
cord-310268-8q4tk6fd	75	11	to	to	TO
cord-310268-8q4tk6fd	75	12	increase	increase	VB
cord-310268-8q4tk6fd	75	13	the	the	DT
cord-310268-8q4tk6fd	75	14	rate	rate	NN
cord-310268-8q4tk6fd	75	15	of	of	IN
cord-310268-8q4tk6fd	75	16	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	75	17	generation	generation	NN
cord-310268-8q4tk6fd	75	18	.	.	.
cord-310268-8q4tk6fd	76	1	Recently	recently	RB
cord-310268-8q4tk6fd	76	2	,	,	,
cord-310268-8q4tk6fd	76	3	this	this	DT
cord-310268-8q4tk6fd	76	4	rapid	rapid	JJ
cord-310268-8q4tk6fd	76	5	one	one	CD
cord-310268-8q4tk6fd	76	6	-	-	HYPH
cord-310268-8q4tk6fd	76	7	step	step	NN
cord-310268-8q4tk6fd	76	8	selection	selection	NN
cord-310268-8q4tk6fd	76	9	method	method	NN
cord-310268-8q4tk6fd	76	10	was	be	VBD
cord-310268-8q4tk6fd	76	11	developed	develop	VBN
cord-310268-8q4tk6fd	76	12	to	to	TO
cord-310268-8q4tk6fd	76	13	select	select	VB
cord-310268-8q4tk6fd	76	14	specific	specific	JJ
cord-310268-8q4tk6fd	76	15	DNA	dna	NN
cord-310268-8q4tk6fd	76	16	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	76	17	using	use	VBG
cord-310268-8q4tk6fd	76	18	only	only	RB
cord-310268-8q4tk6fd	76	19	one	one	CD
cord-310268-8q4tk6fd	76	20	PCR	PCR	NNP
cord-310268-8q4tk6fd	76	21	step	step	NN
cord-310268-8q4tk6fd	76	22	as	as	IN
cord-310268-8q4tk6fd	76	23	summarized	summarize	VBN
cord-310268-8q4tk6fd	76	24	in	in	IN
cord-310268-8q4tk6fd	76	25	Figure	figure	NN
cord-310268-8q4tk6fd	76	26	1C	1c	CD
cord-310268-8q4tk6fd	76	27	[	[	-LRB-
cord-310268-8q4tk6fd	76	28	34	34	CD
cord-310268-8q4tk6fd	76	29	]	]	-RRB-
cord-310268-8q4tk6fd	76	30	.	.	.
cord-310268-8q4tk6fd	77	1	In	in	IN
cord-310268-8q4tk6fd	77	2	this	this	DT
cord-310268-8q4tk6fd	77	3	method	method	NN
cord-310268-8q4tk6fd	77	4	,	,	,
cord-310268-8q4tk6fd	77	5	a	a	DT
cord-310268-8q4tk6fd	77	6	target	target	NN
cord-310268-8q4tk6fd	77	7	immobilized	immobilize	VBN
cord-310268-8q4tk6fd	77	8	on	on	IN
cord-310268-8q4tk6fd	77	9	a	a	DT
cord-310268-8q4tk6fd	77	10	glass	glass	NN
cord-310268-8q4tk6fd	77	11	coverslip	coverslip	NN
cord-310268-8q4tk6fd	77	12	was	be	VBD
cord-310268-8q4tk6fd	77	13	subjected	subject	VBN
cord-310268-8q4tk6fd	77	14	to	to	IN
cord-310268-8q4tk6fd	77	15	carboxyfluorescein	carboxyfluorescein	NNP
cord-310268-8q4tk6fd	77	16	(	(	-LRB-
cord-310268-8q4tk6fd	77	17	FAM)-labeled	fam)-labele	VBN
cord-310268-8q4tk6fd	77	18	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	77	19	acid	acid	NN
cord-310268-8q4tk6fd	77	20	pool	pool	NN
cord-310268-8q4tk6fd	77	21	binding	binding	NN
cord-310268-8q4tk6fd	77	22	,	,	,
cord-310268-8q4tk6fd	77	23	extensive	extensive	JJ
cord-310268-8q4tk6fd	77	24	washing	washing	NN
cord-310268-8q4tk6fd	77	25	and	and	CC
cord-310268-8q4tk6fd	77	26	microscopy	microscopy	NN
cord-310268-8q4tk6fd	77	27	examination	examination	NN
cord-310268-8q4tk6fd	77	28	,	,	,
cord-310268-8q4tk6fd	77	29	followed	follow	VBN
cord-310268-8q4tk6fd	77	30	by	by	IN
cord-310268-8q4tk6fd	77	31	PCR	PCR	NNP
cord-310268-8q4tk6fd	77	32	enrichment	enrichment	NN
cord-310268-8q4tk6fd	77	33	of	of	IN
cord-310268-8q4tk6fd	77	34	the	the	DT
cord-310268-8q4tk6fd	77	35	selected	select	VBN
cord-310268-8q4tk6fd	77	36	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	77	37	.	.	.
cord-310268-8q4tk6fd	78	1	A	a	DT
cord-310268-8q4tk6fd	78	2	control	control	NN
cord-310268-8q4tk6fd	78	3	experiment	experiment	NN
cord-310268-8q4tk6fd	78	4	used	use	VBD
cord-310268-8q4tk6fd	78	5	a	a	DT
cord-310268-8q4tk6fd	78	6	labeled	label	VBN
cord-310268-8q4tk6fd	78	7	target	target	NN
cord-310268-8q4tk6fd	78	8	and	and	CC
cord-310268-8q4tk6fd	78	9	a	a	DT
cord-310268-8q4tk6fd	78	10	labeled	label	VBN
cord-310268-8q4tk6fd	78	11	DNA	dna	NN
cord-310268-8q4tk6fd	78	12	library	library	NN
cord-310268-8q4tk6fd	78	13	was	be	VBD
cord-310268-8q4tk6fd	78	14	used	use	VBN
cord-310268-8q4tk6fd	78	15	to	to	TO
cord-310268-8q4tk6fd	78	16	make	make	VB
cord-310268-8q4tk6fd	78	17	sure	sure	JJ
cord-310268-8q4tk6fd	78	18	the	the	DT
cord-310268-8q4tk6fd	78	19	specificity	specificity	NN
cord-310268-8q4tk6fd	78	20	of	of	IN
cord-310268-8q4tk6fd	78	21	the	the	DT
cord-310268-8q4tk6fd	78	22	selection	selection	NN
cord-310268-8q4tk6fd	78	23	.	.	.
cord-310268-8q4tk6fd	79	1	In	in	IN
cord-310268-8q4tk6fd	79	2	the	the	DT
cord-310268-8q4tk6fd	79	3	overlay	overlay	NN
cord-310268-8q4tk6fd	79	4	image	image	NN
cord-310268-8q4tk6fd	79	5	of	of	IN
cord-310268-8q4tk6fd	79	6	the	the	DT
cord-310268-8q4tk6fd	79	7	immobilized	immobilize	VBN
cord-310268-8q4tk6fd	79	8	target	target	NN
cord-310268-8q4tk6fd	79	9	labeled	label	VBN
cord-310268-8q4tk6fd	79	10	with	with	IN
cord-310268-8q4tk6fd	79	11	Alexa	Alexa	NNP
cord-310268-8q4tk6fd	79	12	Fluor	Fluor	NNP
cord-310268-8q4tk6fd	79	13	555	555	CD
cord-310268-8q4tk6fd	79	14	(	(	-LRB-
cord-310268-8q4tk6fd	79	15	red	red	JJ
cord-310268-8q4tk6fd	79	16	color	color	NN
cord-310268-8q4tk6fd	79	17	)	)	-RRB-
cord-310268-8q4tk6fd	79	18	and	and	CC
cord-310268-8q4tk6fd	79	19	target	target	NN
cord-310268-8q4tk6fd	79	20	bound	bind	VBN
cord-310268-8q4tk6fd	79	21	FAM	FAM	NNP
cord-310268-8q4tk6fd	79	22	-	-	HYPH
cord-310268-8q4tk6fd	79	23	labeled	label	VBN
cord-310268-8q4tk6fd	79	24	DNA	dna	NN
cord-310268-8q4tk6fd	79	25	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	79	26	(	(	-LRB-
cord-310268-8q4tk6fd	79	27	green	green	JJ
cord-310268-8q4tk6fd	79	28	fluorescence	fluorescence	NN
cord-310268-8q4tk6fd	79	29	)	)	-RRB-
cord-310268-8q4tk6fd	79	30	,	,	,
cord-310268-8q4tk6fd	79	31	an	an	DT
cord-310268-8q4tk6fd	79	32	orange	orange	JJ
cord-310268-8q4tk6fd	79	33	color	color	NN
cord-310268-8q4tk6fd	79	34	is	be	VBZ
cord-310268-8q4tk6fd	79	35	observed	observe	VBN
cord-310268-8q4tk6fd	79	36	for	for	IN
cord-310268-8q4tk6fd	79	37	target	target	NN
cord-310268-8q4tk6fd	79	38	-	-	HYPH
cord-310268-8q4tk6fd	79	39	specific	specific	JJ
cord-310268-8q4tk6fd	79	40	selection	selection	NN
cord-310268-8q4tk6fd	79	41	.	.	.
cord-310268-8q4tk6fd	80	1	Although	although	IN
cord-310268-8q4tk6fd	80	2	the	the	DT
cord-310268-8q4tk6fd	80	3	binding	bind	VBG
cord-310268-8q4tk6fd	80	4	affinity	affinity	NN
cord-310268-8q4tk6fd	80	5	of	of	IN
cord-310268-8q4tk6fd	80	6	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	80	7	selected	select	VBN
cord-310268-8q4tk6fd	80	8	with	with	IN
cord-310268-8q4tk6fd	80	9	the	the	DT
cord-310268-8q4tk6fd	80	10	current	current	JJ
cord-310268-8q4tk6fd	80	11	version	version	NN
cord-310268-8q4tk6fd	80	12	of	of	IN
cord-310268-8q4tk6fd	80	13	the	the	DT
cord-310268-8q4tk6fd	80	14	one	one	CD
cord-310268-8q4tk6fd	80	15	-	-	HYPH
cord-310268-8q4tk6fd	80	16	step	step	NN
cord-310268-8q4tk6fd	80	17	method	method	NN
cord-310268-8q4tk6fd	80	18	was	be	VBD
cord-310268-8q4tk6fd	80	19	in	in	IN
cord-310268-8q4tk6fd	80	20	the	the	DT
cord-310268-8q4tk6fd	80	21	low	low	JJ
cord-310268-8q4tk6fd	80	22	micromolar	micromolar	JJ
cord-310268-8q4tk6fd	80	23	range	range	NN
cord-310268-8q4tk6fd	80	24	,	,	,
cord-310268-8q4tk6fd	80	25	it	-PRON-	PRP
cord-310268-8q4tk6fd	80	26	was	be	VBD
cord-310268-8q4tk6fd	80	27	believed	believe	VBN
cord-310268-8q4tk6fd	80	28	that	that	IN
cord-310268-8q4tk6fd	80	29	it	-PRON-	PRP
cord-310268-8q4tk6fd	80	30	can	can	MD
cord-310268-8q4tk6fd	80	31	be	be	VB
cord-310268-8q4tk6fd	80	32	further	further	RB
cord-310268-8q4tk6fd	80	33	improved	improve	VBN
cord-310268-8q4tk6fd	80	34	by	by	IN
cord-310268-8q4tk6fd	80	35	using	use	VBG
cord-310268-8q4tk6fd	80	36	larger	large	JJR
cord-310268-8q4tk6fd	80	37	targets	target	NNS
cord-310268-8q4tk6fd	80	38	,	,	,
cord-310268-8q4tk6fd	80	39	increasing	increase	VBG
cord-310268-8q4tk6fd	80	40	the	the	DT
cord-310268-8q4tk6fd	80	41	stringency	stringency	NN
cord-310268-8q4tk6fd	80	42	of	of	IN
cord-310268-8q4tk6fd	80	43	selection	selection	NN
cord-310268-8q4tk6fd	80	44	,	,	,
cord-310268-8q4tk6fd	80	45	and	and	CC
cord-310268-8q4tk6fd	80	46	by	by	IN
cord-310268-8q4tk6fd	80	47	combining	combine	VBG
cord-310268-8q4tk6fd	80	48	it	-PRON-	PRP
cord-310268-8q4tk6fd	80	49	with	with	IN
cord-310268-8q4tk6fd	80	50	a	a	DT
cord-310268-8q4tk6fd	80	51	capillary	capillary	JJ
cord-310268-8q4tk6fd	80	52	electrophoresis	electrophoresis	NN
cord-310268-8q4tk6fd	80	53	separation	separation	NN
cord-310268-8q4tk6fd	80	54	.	.	.
cord-310268-8q4tk6fd	81	1	This	this	DT
cord-310268-8q4tk6fd	81	2	method	method	NN
cord-310268-8q4tk6fd	81	3	was	be	VBD
cord-310268-8q4tk6fd	81	4	described	describe	VBN
cord-310268-8q4tk6fd	81	5	as	as	IN
cord-310268-8q4tk6fd	81	6	a	a	DT
cord-310268-8q4tk6fd	81	7	user	user	NN
cord-310268-8q4tk6fd	81	8	-	-	HYPH
cord-310268-8q4tk6fd	81	9	friendly	friendly	JJ
cord-310268-8q4tk6fd	81	10	,	,	,
cord-310268-8q4tk6fd	81	11	low	low	JJ
cord-310268-8q4tk6fd	81	12	-	-	HYPH
cord-310268-8q4tk6fd	81	13	cost	cost	NN
cord-310268-8q4tk6fd	81	14	and	and	CC
cord-310268-8q4tk6fd	81	15	easy	easy	JJ
cord-310268-8q4tk6fd	81	16	way	way	NN
cord-310268-8q4tk6fd	81	17	to	to	TO
cord-310268-8q4tk6fd	81	18	select	select	VB
cord-310268-8q4tk6fd	81	19	DNA	DNA	NNP
cord-310268-8q4tk6fd	81	20	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	81	21	.	.	.
cord-310268-8q4tk6fd	82	1	In	in	IN
cord-310268-8q4tk6fd	82	2	particular	particular	JJ
cord-310268-8q4tk6fd	82	3	,	,	,
cord-310268-8q4tk6fd	82	4	this	this	DT
cord-310268-8q4tk6fd	82	5	method	method	NN
cord-310268-8q4tk6fd	82	6	allows	allow	VBZ
cord-310268-8q4tk6fd	82	7	the	the	DT
cord-310268-8q4tk6fd	82	8	use	use	NN
cord-310268-8q4tk6fd	82	9	of	of	IN
cord-310268-8q4tk6fd	82	10	a	a	DT
cord-310268-8q4tk6fd	82	11	chemically	chemically	RB
cord-310268-8q4tk6fd	82	12	modified	modify	VBN
cord-310268-8q4tk6fd	82	13	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	82	14	acid	acid	NN
cord-310268-8q4tk6fd	82	15	library	library	NN
cord-310268-8q4tk6fd	82	16	directly	directly	RB
cord-310268-8q4tk6fd	82	17	as	as	IN
cord-310268-8q4tk6fd	82	18	it	-PRON-	PRP
cord-310268-8q4tk6fd	82	19	requires	require	VBZ
cord-310268-8q4tk6fd	82	20	only	only	RB
cord-310268-8q4tk6fd	82	21	one	one	CD
cord-310268-8q4tk6fd	82	22	PCR	PCR	NNP
cord-310268-8q4tk6fd	82	23	step	step	NN
cord-310268-8q4tk6fd	82	24	.	.	.
cord-310268-8q4tk6fd	83	1	Moreover	moreover	RB
cord-310268-8q4tk6fd	83	2	,	,	,
cord-310268-8q4tk6fd	83	3	a	a	DT
cord-310268-8q4tk6fd	83	4	DNA	dna	NN
cord-310268-8q4tk6fd	83	5	microarray	microarray	NN
cord-310268-8q4tk6fd	83	6	has	have	VBZ
cord-310268-8q4tk6fd	83	7	been	be	VBN
cord-310268-8q4tk6fd	83	8	utilized	utilize	VBN
cord-310268-8q4tk6fd	83	9	to	to	TO
cord-310268-8q4tk6fd	83	10	achieve	achieve	VB
cord-310268-8q4tk6fd	83	11	one	one	CD
cord-310268-8q4tk6fd	83	12	-	-	HYPH
cord-310268-8q4tk6fd	83	13	step	step	NN
cord-310268-8q4tk6fd	83	14	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	83	15	identification	identification	NN
cord-310268-8q4tk6fd	83	16	,	,	,
cord-310268-8q4tk6fd	83	17	in	in	IN
cord-310268-8q4tk6fd	83	18	which	which	WDT
cord-310268-8q4tk6fd	83	19	the	the	DT
cord-310268-8q4tk6fd	83	20	sequences	sequence	NNS
cord-310268-8q4tk6fd	83	21	of	of	IN
cord-310268-8q4tk6fd	83	22	interest	interest	NN
cord-310268-8q4tk6fd	83	23	can	can	MD
cord-310268-8q4tk6fd	83	24	be	be	VB
cord-310268-8q4tk6fd	83	25	produced	produce	VBN
cord-310268-8q4tk6fd	83	26	on	on	IN
cord-310268-8q4tk6fd	83	27	the	the	DT
cord-310268-8q4tk6fd	83	28	arrays	array	NNS
cord-310268-8q4tk6fd	83	29	for	for	IN
cord-310268-8q4tk6fd	83	30	selection	selection	NN
cord-310268-8q4tk6fd	83	31	and	and	CC
cord-310268-8q4tk6fd	83	32	PCR	PCR	NNP
cord-310268-8q4tk6fd	83	33	,	,	,
cord-310268-8q4tk6fd	83	34	cloning	cloning	NN
cord-310268-8q4tk6fd	83	35	and	and	CC
cord-310268-8q4tk6fd	83	36	sequencing	sequencing	NN
cord-310268-8q4tk6fd	83	37	are	be	VBP
cord-310268-8q4tk6fd	83	38	not	not	RB
cord-310268-8q4tk6fd	83	39	required	require	VBN
cord-310268-8q4tk6fd	83	40	[	[	-LRB-
cord-310268-8q4tk6fd	83	41	35	35	CD
cord-310268-8q4tk6fd	83	42	,	,	,
cord-310268-8q4tk6fd	83	43	36	36	CD
cord-310268-8q4tk6fd	83	44	]	]	-RRB-
cord-310268-8q4tk6fd	83	45	.	.	.
cord-310268-8q4tk6fd	84	1	Molecules	molecule	NNS
cord-310268-8q4tk6fd	84	2	2015	2015	CD
cord-310268-8q4tk6fd	84	3	,	,	,
cord-310268-8q4tk6fd	84	4	20	20	CD
cord-310268-8q4tk6fd	84	5	,	,	,
cord-310268-8q4tk6fd	84	6	page	page	NN
cord-310268-8q4tk6fd	84	7	-	-	HYPH
cord-310268-8q4tk6fd	84	8	page	page	NN
cord-310268-8q4tk6fd	84	9	4	4	CD
cord-310268-8q4tk6fd	84	10	selected	select	VBN
cord-310268-8q4tk6fd	84	11	with	with	IN
cord-310268-8q4tk6fd	84	12	the	the	DT
cord-310268-8q4tk6fd	84	13	current	current	JJ
cord-310268-8q4tk6fd	84	14	version	version	NN
cord-310268-8q4tk6fd	84	15	of	of	IN
cord-310268-8q4tk6fd	84	16	the	the	DT
cord-310268-8q4tk6fd	84	17	one	one	CD
cord-310268-8q4tk6fd	84	18	-	-	HYPH
cord-310268-8q4tk6fd	84	19	step	step	NN
cord-310268-8q4tk6fd	84	20	method	method	NN
cord-310268-8q4tk6fd	84	21	was	be	VBD
cord-310268-8q4tk6fd	84	22	in	in	IN
cord-310268-8q4tk6fd	84	23	the	the	DT
cord-310268-8q4tk6fd	84	24	low	low	JJ
cord-310268-8q4tk6fd	84	25	micromolar	micromolar	JJ
cord-310268-8q4tk6fd	84	26	range	range	NN
cord-310268-8q4tk6fd	84	27	,	,	,
cord-310268-8q4tk6fd	84	28	it	-PRON-	PRP
cord-310268-8q4tk6fd	84	29	was	be	VBD
cord-310268-8q4tk6fd	84	30	believed	believe	VBN
cord-310268-8q4tk6fd	84	31	that	that	IN
cord-310268-8q4tk6fd	84	32	it	-PRON-	PRP
cord-310268-8q4tk6fd	84	33	can	can	MD
cord-310268-8q4tk6fd	84	34	be	be	VB
cord-310268-8q4tk6fd	84	35	further	further	RB
cord-310268-8q4tk6fd	84	36	improved	improve	VBN
cord-310268-8q4tk6fd	84	37	by	by	IN
cord-310268-8q4tk6fd	84	38	using	use	VBG
cord-310268-8q4tk6fd	84	39	larger	large	JJR
cord-310268-8q4tk6fd	84	40	targets	target	NNS
cord-310268-8q4tk6fd	84	41	,	,	,
cord-310268-8q4tk6fd	84	42	increasing	increase	VBG
cord-310268-8q4tk6fd	84	43	the	the	DT
cord-310268-8q4tk6fd	84	44	stringency	stringency	NN
cord-310268-8q4tk6fd	84	45	of	of	IN
cord-310268-8q4tk6fd	84	46	selection	selection	NN
cord-310268-8q4tk6fd	84	47	,	,	,
cord-310268-8q4tk6fd	84	48	and	and	CC
cord-310268-8q4tk6fd	84	49	by	by	IN
cord-310268-8q4tk6fd	84	50	combining	combine	VBG
cord-310268-8q4tk6fd	84	51	it	-PRON-	PRP
cord-310268-8q4tk6fd	84	52	with	with	IN
cord-310268-8q4tk6fd	84	53	a	a	DT
cord-310268-8q4tk6fd	84	54	capillary	capillary	JJ
cord-310268-8q4tk6fd	84	55	electrophoresis	electrophoresis	NN
cord-310268-8q4tk6fd	84	56	separation	separation	NN
cord-310268-8q4tk6fd	84	57	.	.	.
cord-310268-8q4tk6fd	85	1	This	this	DT
cord-310268-8q4tk6fd	85	2	method	method	NN
cord-310268-8q4tk6fd	85	3	was	be	VBD
cord-310268-8q4tk6fd	85	4	described	describe	VBN
cord-310268-8q4tk6fd	85	5	as	as	IN
cord-310268-8q4tk6fd	85	6	a	a	DT
cord-310268-8q4tk6fd	85	7	user	user	NN
cord-310268-8q4tk6fd	85	8	-	-	HYPH
cord-310268-8q4tk6fd	85	9	friendly	friendly	JJ
cord-310268-8q4tk6fd	85	10	,	,	,
cord-310268-8q4tk6fd	85	11	low	low	JJ
cord-310268-8q4tk6fd	85	12	-	-	HYPH
cord-310268-8q4tk6fd	85	13	cost	cost	NN
cord-310268-8q4tk6fd	85	14	and	and	CC
cord-310268-8q4tk6fd	85	15	easy	easy	JJ
cord-310268-8q4tk6fd	85	16	way	way	NN
cord-310268-8q4tk6fd	85	17	to	to	TO
cord-310268-8q4tk6fd	85	18	select	select	VB
cord-310268-8q4tk6fd	85	19	DNA	DNA	NNP
cord-310268-8q4tk6fd	85	20	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	85	21	.	.	.
cord-310268-8q4tk6fd	86	1	In	in	IN
cord-310268-8q4tk6fd	86	2	particular	particular	JJ
cord-310268-8q4tk6fd	86	3	,	,	,
cord-310268-8q4tk6fd	86	4	this	this	DT
cord-310268-8q4tk6fd	86	5	method	method	NN
cord-310268-8q4tk6fd	86	6	allows	allow	VBZ
cord-310268-8q4tk6fd	86	7	the	the	DT
cord-310268-8q4tk6fd	86	8	use	use	NN
cord-310268-8q4tk6fd	86	9	of	of	IN
cord-310268-8q4tk6fd	86	10	a	a	DT
cord-310268-8q4tk6fd	86	11	chemically	chemically	RB
cord-310268-8q4tk6fd	86	12	modified	modify	VBN
cord-310268-8q4tk6fd	86	13	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	86	14	acid	acid	NN
cord-310268-8q4tk6fd	86	15	library	library	NN
cord-310268-8q4tk6fd	86	16	directly	directly	RB
cord-310268-8q4tk6fd	86	17	as	as	IN
cord-310268-8q4tk6fd	86	18	it	-PRON-	PRP
cord-310268-8q4tk6fd	86	19	requires	require	VBZ
cord-310268-8q4tk6fd	86	20	only	only	RB
cord-310268-8q4tk6fd	86	21	one	one	CD
cord-310268-8q4tk6fd	86	22	PCR	PCR	NNP
cord-310268-8q4tk6fd	86	23	step	step	NN
cord-310268-8q4tk6fd	86	24	.	.	.
cord-310268-8q4tk6fd	87	1	Moreover	moreover	RB
cord-310268-8q4tk6fd	87	2	,	,	,
cord-310268-8q4tk6fd	87	3	a	a	DT
cord-310268-8q4tk6fd	87	4	DNA	dna	NN
cord-310268-8q4tk6fd	87	5	microarray	microarray	NN
cord-310268-8q4tk6fd	87	6	has	have	VBZ
cord-310268-8q4tk6fd	87	7	been	be	VBN
cord-310268-8q4tk6fd	87	8	utilized	utilize	VBN
cord-310268-8q4tk6fd	87	9	to	to	TO
cord-310268-8q4tk6fd	87	10	achieve	achieve	VB
cord-310268-8q4tk6fd	87	11	one	one	CD
cord-310268-8q4tk6fd	87	12	-	-	HYPH
cord-310268-8q4tk6fd	87	13	step	step	NN
cord-310268-8q4tk6fd	87	14	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	87	15	identification	identification	NN
cord-310268-8q4tk6fd	87	16	,	,	,
cord-310268-8q4tk6fd	87	17	in	in	IN
cord-310268-8q4tk6fd	87	18	which	which	WDT
cord-310268-8q4tk6fd	87	19	the	the	DT
cord-310268-8q4tk6fd	87	20	sequences	sequence	NNS
cord-310268-8q4tk6fd	87	21	of	of	IN
cord-310268-8q4tk6fd	87	22	interest	interest	NN
cord-310268-8q4tk6fd	87	23	can	can	MD
cord-310268-8q4tk6fd	87	24	be	be	VB
cord-310268-8q4tk6fd	87	25	produced	produce	VBN
cord-310268-8q4tk6fd	87	26	on	on	IN
cord-310268-8q4tk6fd	87	27	the	the	DT
cord-310268-8q4tk6fd	87	28	arrays	array	NNS
cord-310268-8q4tk6fd	87	29	for	for	IN
cord-310268-8q4tk6fd	87	30	selection	selection	NN
cord-310268-8q4tk6fd	87	31	and	and	CC
cord-310268-8q4tk6fd	87	32	PCR	PCR	NNP
cord-310268-8q4tk6fd	87	33	,	,	,
cord-310268-8q4tk6fd	87	34	cloning	cloning	NN
cord-310268-8q4tk6fd	87	35	and	and	CC
cord-310268-8q4tk6fd	87	36	sequencing	sequencing	NN
cord-310268-8q4tk6fd	87	37	are	be	VBP
cord-310268-8q4tk6fd	87	38	not	not	RB
cord-310268-8q4tk6fd	87	39	required	require	VBN
cord-310268-8q4tk6fd	87	40	[	[	-LRB-
cord-310268-8q4tk6fd	87	41	35	35	CD
cord-310268-8q4tk6fd	87	42	,	,	,
cord-310268-8q4tk6fd	87	43	36	36	CD
cord-310268-8q4tk6fd	87	44	]	]	-RRB-
cord-310268-8q4tk6fd	87	45	.	.	.
cord-310268-8q4tk6fd	88	1	The	the	DT
cord-310268-8q4tk6fd	88	2	target	target	NN
cord-310268-8q4tk6fd	88	3	-	-	HYPH
cord-310268-8q4tk6fd	88	4	coated	coat	VBN
cord-310268-8q4tk6fd	88	5	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	88	6	beads	bead	NNS
cord-310268-8q4tk6fd	88	7	are	be	VBP
cord-310268-8q4tk6fd	88	8	incubated	incubate	VBN
cord-310268-8q4tk6fd	88	9	with	with	IN
cord-310268-8q4tk6fd	88	10	the	the	DT
cord-310268-8q4tk6fd	88	11	ssDNA	ssdna	JJ
cord-310268-8q4tk6fd	88	12	pool	pool	NN
cord-310268-8q4tk6fd	88	13	.	.	.
cord-310268-8q4tk6fd	89	1	The	the	DT
cord-310268-8q4tk6fd	89	2	beads	bead	NNS
cord-310268-8q4tk6fd	89	3	with	with	IN
cord-310268-8q4tk6fd	89	4	bound	bound	JJ
cord-310268-8q4tk6fd	89	5	sequences	sequence	NNS
cord-310268-8q4tk6fd	89	6	are	be	VBP
cord-310268-8q4tk6fd	89	7	then	then	RB
cord-310268-8q4tk6fd	89	8	separated	separate	VBN
cord-310268-8q4tk6fd	89	9	from	from	IN
cord-310268-8q4tk6fd	89	10	the	the	DT
cord-310268-8q4tk6fd	89	11	unbound	unbound	JJ
cord-310268-8q4tk6fd	89	12	sequences	sequence	NNS
cord-310268-8q4tk6fd	89	13	with	with	IN
cord-310268-8q4tk6fd	89	14	a	a	DT
cord-310268-8q4tk6fd	89	15	U	u	NN
cord-310268-8q4tk6fd	89	16	-	-	HYPH
cord-310268-8q4tk6fd	89	17	shaped	shape	VBN
cord-310268-8q4tk6fd	89	18	magnet	magnet	NN
cord-310268-8q4tk6fd	89	19	or	or	CC
cord-310268-8q4tk6fd	89	20	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	89	21	stand	stand	NN
cord-310268-8q4tk6fd	89	22	.	.	.
cord-310268-8q4tk6fd	90	1	After	after	IN
cord-310268-8q4tk6fd	90	2	re	re	NN
cord-310268-8q4tk6fd	90	3	-	-	NN
cord-310268-8q4tk6fd	90	4	dispersion	dispersion	NN
cord-310268-8q4tk6fd	90	5	,	,	,
cord-310268-8q4tk6fd	90	6	the	the	DT
cord-310268-8q4tk6fd	90	7	beads	bead	NNS
cord-310268-8q4tk6fd	90	8	are	be	VBP
cord-310268-8q4tk6fd	90	9	put	put	VBN
cord-310268-8q4tk6fd	90	10	in	in	IN
cord-310268-8q4tk6fd	90	11	an	an	DT
cord-310268-8q4tk6fd	90	12	externally	externally	RB
cord-310268-8q4tk6fd	90	13	applied	apply	VBN
cord-310268-8q4tk6fd	90	14	rotating	rotate	VBG
cord-310268-8q4tk6fd	90	15	or	or	CC
cord-310268-8q4tk6fd	90	16	alternating	alternate	VBG
cord-310268-8q4tk6fd	90	17	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	90	18	field	field	NN
cord-310268-8q4tk6fd	90	19	.	.	.
cord-310268-8q4tk6fd	91	1	During	during	IN
cord-310268-8q4tk6fd	91	2	this	this	DT
cord-310268-8q4tk6fd	91	3	process	process	NN
cord-310268-8q4tk6fd	91	4	,	,	,
cord-310268-8q4tk6fd	91	5	the	the	DT
cord-310268-8q4tk6fd	91	6	weak	weak	JJ
cord-310268-8q4tk6fd	91	7	and	and	CC
cord-310268-8q4tk6fd	91	8	non	non	JJ
cord-310268-8q4tk6fd	91	9	-	-	JJ
cord-310268-8q4tk6fd	91	10	specific	specific	JJ
cord-310268-8q4tk6fd	91	11	binding	binding	NN
cord-310268-8q4tk6fd	91	12	sequences	sequence	NNS
cord-310268-8q4tk6fd	91	13	are	be	VBP
cord-310268-8q4tk6fd	91	14	released	release	VBN
cord-310268-8q4tk6fd	91	15	and	and	CC
cord-310268-8q4tk6fd	91	16	separated	separate	VBN
cord-310268-8q4tk6fd	91	17	.	.	.
cord-310268-8q4tk6fd	92	1	The	the	DT
cord-310268-8q4tk6fd	92	2	strong	strong	RB
cord-310268-8q4tk6fd	92	3	-	-	HYPH
cord-310268-8q4tk6fd	92	4	binding	bind	VBG
cord-310268-8q4tk6fd	92	5	sequences	sequence	NNS
cord-310268-8q4tk6fd	92	6	are	be	VBP
cord-310268-8q4tk6fd	92	7	finally	finally	RB
cord-310268-8q4tk6fd	92	8	released	release	VBN
cord-310268-8q4tk6fd	92	9	from	from	IN
cord-310268-8q4tk6fd	92	10	the	the	DT
cord-310268-8q4tk6fd	92	11	beads	bead	NNS
cord-310268-8q4tk6fd	92	12	by	by	IN
cord-310268-8q4tk6fd	92	13	heating	heating	NN
cord-310268-8q4tk6fd	92	14	and	and	CC
cord-310268-8q4tk6fd	92	15	then	then	RB
cord-310268-8q4tk6fd	92	16	incubated	incubate	VBN
cord-310268-8q4tk6fd	92	17	with	with	IN
cord-310268-8q4tk6fd	92	18	the	the	DT
cord-310268-8q4tk6fd	92	19	beads	bead	NNS
cord-310268-8q4tk6fd	92	20	without	without	IN
cord-310268-8q4tk6fd	92	21	a	a	DT
cord-310268-8q4tk6fd	92	22	target	target	NN
cord-310268-8q4tk6fd	92	23	for	for	IN
cord-310268-8q4tk6fd	92	24	the	the	DT
cord-310268-8q4tk6fd	92	25	negative	negative	JJ
cord-310268-8q4tk6fd	92	26	selection	selection	NN
cord-310268-8q4tk6fd	92	27	.	.	.
cord-310268-8q4tk6fd	93	1	The	the	DT
cord-310268-8q4tk6fd	93	2	selected	select	VBN
cord-310268-8q4tk6fd	93	3	sequences	sequence	NNS
cord-310268-8q4tk6fd	93	4	are	be	VBP
cord-310268-8q4tk6fd	93	5	amplified	amplify	VBN
cord-310268-8q4tk6fd	93	6	,	,	,
cord-310268-8q4tk6fd	93	7	cloned	clone	VBN
cord-310268-8q4tk6fd	93	8	and	and	CC
cord-310268-8q4tk6fd	93	9	sequenced	sequence	VBN
cord-310268-8q4tk6fd	93	10	as	as	IN
cord-310268-8q4tk6fd	93	11	usual	usual	JJ
cord-310268-8q4tk6fd	93	12	;	;	:
cord-310268-8q4tk6fd	93	13	(	(	-LRB-
cord-310268-8q4tk6fd	93	14	C	c	NN
cord-310268-8q4tk6fd	93	15	)	)	-RRB-
cord-310268-8q4tk6fd	93	16	One	one	CD
cord-310268-8q4tk6fd	93	17	-	-	HYPH
cord-310268-8q4tk6fd	93	18	step	step	NN
cord-310268-8q4tk6fd	93	19	Selection	selection	NN
cord-310268-8q4tk6fd	93	20	:	:	:
cord-310268-8q4tk6fd	94	1	A	a	DT
cord-310268-8q4tk6fd	94	2	FAM	FAM	NNP
cord-310268-8q4tk6fd	94	3	-	-	HYPH
cord-310268-8q4tk6fd	94	4	labeled	label	VBN
cord-310268-8q4tk6fd	94	5	oligonucleotide	oligonucleotide	JJ
cord-310268-8q4tk6fd	94	6	library	library	NN
cord-310268-8q4tk6fd	94	7	is	be	VBZ
cord-310268-8q4tk6fd	94	8	incubated	incubate	VBN
cord-310268-8q4tk6fd	94	9	with	with	IN
cord-310268-8q4tk6fd	94	10	a	a	DT
cord-310268-8q4tk6fd	94	11	target	target	NN
cord-310268-8q4tk6fd	94	12	immobilized	immobilize	VBN
cord-310268-8q4tk6fd	94	13	on	on	IN
cord-310268-8q4tk6fd	94	14	a	a	DT
cord-310268-8q4tk6fd	94	15	glass	glass	NN
cord-310268-8q4tk6fd	94	16	coverslip	coverslip	NN
cord-310268-8q4tk6fd	94	17	that	that	WDT
cord-310268-8q4tk6fd	94	18	was	be	VBD
cord-310268-8q4tk6fd	94	19	coated	coat	VBN
cord-310268-8q4tk6fd	94	20	with	with	IN
cord-310268-8q4tk6fd	94	21	N	n	NN
cord-310268-8q4tk6fd	94	22	-	-	HYPH
cord-310268-8q4tk6fd	94	23	hydroxysuccinimide	hydroxysuccinimide	NNP
cord-310268-8q4tk6fd	94	24	(	(	-LRB-
cord-310268-8q4tk6fd	94	25	NHS	NHS	NNP
cord-310268-8q4tk6fd	94	26	)	)	-RRB-
cord-310268-8q4tk6fd	94	27	functionalized	functionalize	VBD
cord-310268-8q4tk6fd	94	28	polyethylene	polyethylene	NN
cord-310268-8q4tk6fd	94	29	glycol	glycol	NN
cord-310268-8q4tk6fd	94	30	(	(	-LRB-
cord-310268-8q4tk6fd	94	31	PEG	PEG	NNP
cord-310268-8q4tk6fd	94	32	)	)	-RRB-
cord-310268-8q4tk6fd	94	33	.	.	.
cord-310268-8q4tk6fd	95	1	Unbound	unbound	JJ
cord-310268-8q4tk6fd	95	2	sequences	sequence	NNS
cord-310268-8q4tk6fd	95	3	are	be	VBP
cord-310268-8q4tk6fd	95	4	discarded	discard	VBN
cord-310268-8q4tk6fd	95	5	by	by	IN
cord-310268-8q4tk6fd	95	6	extensive	extensive	JJ
cord-310268-8q4tk6fd	95	7	washing	washing	NN
cord-310268-8q4tk6fd	95	8	followed	follow	VBN
cord-310268-8q4tk6fd	95	9	by	by	IN
cord-310268-8q4tk6fd	95	10	monitoring	monitor	VBG
cord-310268-8q4tk6fd	95	11	with	with	IN
cord-310268-8q4tk6fd	95	12	fluorescence	fluorescence	NN
cord-310268-8q4tk6fd	95	13	microscopy	microscopy	NN
cord-310268-8q4tk6fd	95	14	.	.	.
cord-310268-8q4tk6fd	96	1	The	the	DT
cord-310268-8q4tk6fd	96	2	coverslip	coverslip	NN
cord-310268-8q4tk6fd	96	3	is	be	VBZ
cord-310268-8q4tk6fd	96	4	later	later	RB
cord-310268-8q4tk6fd	96	5	crushed	crush	VBN
cord-310268-8q4tk6fd	96	6	and	and	CC
cord-310268-8q4tk6fd	96	7	the	the	DT
cord-310268-8q4tk6fd	96	8	bound	bound	JJ
cord-310268-8q4tk6fd	96	9	sequences	sequence	NNS
cord-310268-8q4tk6fd	96	10	are	be	VBP
cord-310268-8q4tk6fd	96	11	eluted	elute	VBN
cord-310268-8q4tk6fd	96	12	by	by	IN
cord-310268-8q4tk6fd	96	13	heating	heat	VBG
cord-310268-8q4tk6fd	96	14	in	in	IN
cord-310268-8q4tk6fd	96	15	water	water	NN
cord-310268-8q4tk6fd	96	16	.	.	.
cord-310268-8q4tk6fd	97	1	The	the	DT
cord-310268-8q4tk6fd	97	2	selected	select	VBN
cord-310268-8q4tk6fd	97	3	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	97	4	are	be	VBP
cord-310268-8q4tk6fd	97	5	amplified	amplify	VBN
cord-310268-8q4tk6fd	97	6	,	,	,
cord-310268-8q4tk6fd	97	7	cloned	clone	VBN
cord-310268-8q4tk6fd	97	8	and	and	CC
cord-310268-8q4tk6fd	97	9	sequenced	sequence	VBN
cord-310268-8q4tk6fd	97	10	as	as	IN
cord-310268-8q4tk6fd	97	11	usual	usual	JJ
cord-310268-8q4tk6fd	97	12	.	.	.
cord-310268-8q4tk6fd	98	1	DNA	DNA	NNP
cord-310268-8q4tk6fd	98	2	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	98	3	are	be	VBP
cord-310268-8q4tk6fd	98	4	well	well	RB
cord-310268-8q4tk6fd	98	5	known	know	VBN
cord-310268-8q4tk6fd	98	6	to	to	TO
cord-310268-8q4tk6fd	98	7	be	be	VB
cord-310268-8q4tk6fd	98	8	more	more	RBR
cord-310268-8q4tk6fd	98	9	stable	stable	JJ
cord-310268-8q4tk6fd	98	10	than	than	IN
cord-310268-8q4tk6fd	98	11	RNA	RNA	NNP
cord-310268-8q4tk6fd	98	12	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	98	13	,	,	,
cord-310268-8q4tk6fd	98	14	which	which	WDT
cord-310268-8q4tk6fd	98	15	allows	allow	VBZ
cord-310268-8q4tk6fd	98	16	them	-PRON-	PRP
cord-310268-8q4tk6fd	98	17	to	to	TO
cord-310268-8q4tk6fd	98	18	be	be	VB
cord-310268-8q4tk6fd	98	19	readily	readily	RB
cord-310268-8q4tk6fd	98	20	used	use	VBN
cord-310268-8q4tk6fd	98	21	in	in	IN
cord-310268-8q4tk6fd	98	22	the	the	DT
cord-310268-8q4tk6fd	98	23	primary	primary	JJ
cord-310268-8q4tk6fd	98	24	stage	stage	NN
cord-310268-8q4tk6fd	98	25	of	of	IN
cord-310268-8q4tk6fd	98	26	developing	develop	VBG
cord-310268-8q4tk6fd	98	27	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	98	28	tools	tool	NNS
cord-310268-8q4tk6fd	98	29	.	.	.
cord-310268-8q4tk6fd	99	1	However	however	RB
cord-310268-8q4tk6fd	99	2	,	,	,
cord-310268-8q4tk6fd	99	3	the	the	DT
cord-310268-8q4tk6fd	99	4	degradation	degradation	NN
cord-310268-8q4tk6fd	99	5	of	of	IN
cord-310268-8q4tk6fd	99	6	DNA	dna	NN
cord-310268-8q4tk6fd	99	7	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	99	8	by	by	IN
cord-310268-8q4tk6fd	99	9	nuclease	nuclease	NNP
cord-310268-8q4tk6fd	99	10	is	be	VBZ
cord-310268-8q4tk6fd	99	11	still	still	RB
cord-310268-8q4tk6fd	99	12	a	a	DT
cord-310268-8q4tk6fd	99	13	serious	serious	JJ
cord-310268-8q4tk6fd	99	14	problem	problem	NN
cord-310268-8q4tk6fd	99	15	that	that	WDT
cord-310268-8q4tk6fd	99	16	limits	limit	VBZ
cord-310268-8q4tk6fd	99	17	their	-PRON-	PRP$
cord-310268-8q4tk6fd	99	18	clinical	clinical	JJ
cord-310268-8q4tk6fd	99	19	application	application	NN
cord-310268-8q4tk6fd	99	20	,	,	,
cord-310268-8q4tk6fd	99	21	when	when	WRB
cord-310268-8q4tk6fd	99	22	they	-PRON-	PRP
cord-310268-8q4tk6fd	99	23	are	be	VBP
cord-310268-8q4tk6fd	99	24	subjected	subject	VBN
cord-310268-8q4tk6fd	99	25	to	to	IN
cord-310268-8q4tk6fd	99	26	complicated	complicated	JJ
cord-310268-8q4tk6fd	99	27	biological	biological	JJ
cord-310268-8q4tk6fd	99	28	samples	sample	NNS
cord-310268-8q4tk6fd	99	29	.	.	.
cord-310268-8q4tk6fd	100	1	To	to	TO
cord-310268-8q4tk6fd	100	2	improve	improve	VB
cord-310268-8q4tk6fd	100	3	the	the	DT
cord-310268-8q4tk6fd	100	4	nuclease	nuclease	NN
cord-310268-8q4tk6fd	100	5	resistance	resistance	NN
cord-310268-8q4tk6fd	100	6	of	of	IN
cord-310268-8q4tk6fd	100	7	DNA	dna	NN
cord-310268-8q4tk6fd	100	8	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	100	9	,	,	,
cord-310268-8q4tk6fd	101	1	one	one	CD
cord-310268-8q4tk6fd	101	2	Those	those	DT
cord-310268-8q4tk6fd	101	3	that	that	WDT
cord-310268-8q4tk6fd	101	4	do	do	VBP
cord-310268-8q4tk6fd	101	5	not	not	RB
cord-310268-8q4tk6fd	101	6	bind	bind	VB
cord-310268-8q4tk6fd	101	7	to	to	IN
cord-310268-8q4tk6fd	101	8	negative	negative	JJ
cord-310268-8q4tk6fd	101	9	targets	target	NNS
cord-310268-8q4tk6fd	101	10	are	be	VBP
cord-310268-8q4tk6fd	101	11	retained	retain	VBN
cord-310268-8q4tk6fd	101	12	and	and	CC
cord-310268-8q4tk6fd	101	13	amplified	amplify	VBN
cord-310268-8q4tk6fd	101	14	by	by	IN
cord-310268-8q4tk6fd	101	15	PCR	PCR	NNP
cord-310268-8q4tk6fd	101	16	.	.	.
cord-310268-8q4tk6fd	102	1	The	the	DT
cord-310268-8q4tk6fd	102	2	PCR	PCR	NNP
cord-310268-8q4tk6fd	102	3	products	product	NNS
cord-310268-8q4tk6fd	102	4	are	be	VBP
cord-310268-8q4tk6fd	102	5	separated	separate	VBN
cord-310268-8q4tk6fd	102	6	into	into	IN
cord-310268-8q4tk6fd	102	7	ssDNA	ssdna	NN
cord-310268-8q4tk6fd	102	8	for	for	IN
cord-310268-8q4tk6fd	102	9	further	further	JJ
cord-310268-8q4tk6fd	102	10	rounds	round	NNS
cord-310268-8q4tk6fd	102	11	.	.	.
cord-310268-8q4tk6fd	103	1	After	after	IN
cord-310268-8q4tk6fd	103	2	10	10	CD
cord-310268-8q4tk6fd	103	3	-	-	SYM
cord-310268-8q4tk6fd	103	4	20	20	CD
cord-310268-8q4tk6fd	103	5	cycles	cycle	NNS
cord-310268-8q4tk6fd	103	6	,	,	,
cord-310268-8q4tk6fd	103	7	the	the	DT
cord-310268-8q4tk6fd	103	8	selected	select	VBN
cord-310268-8q4tk6fd	103	9	ssDNAs	ssdna	NNS
cord-310268-8q4tk6fd	103	10	are	be	VBP
cord-310268-8q4tk6fd	103	11	cloned	clone	VBN
cord-310268-8q4tk6fd	103	12	and	and	CC
cord-310268-8q4tk6fd	103	13	sequenced	sequence	VBN
cord-310268-8q4tk6fd	103	14	for	for	IN
cord-310268-8q4tk6fd	103	15	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	103	16	identification	identification	NN
cord-310268-8q4tk6fd	103	17	;	;	:
cord-310268-8q4tk6fd	103	18	(	(	-LRB-
cord-310268-8q4tk6fd	103	19	B	b	NN
cord-310268-8q4tk6fd	103	20	)	)	-RRB-
cord-310268-8q4tk6fd	103	21	Magnetic	Magnetic	NNP
cord-310268-8q4tk6fd	103	22	-	-	HYPH
cord-310268-8q4tk6fd	103	23	assisted	assist	VBN
cord-310268-8q4tk6fd	103	24	rapid	rapid	JJ
cord-310268-8q4tk6fd	103	25	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	103	26	selection	selection	NN
cord-310268-8q4tk6fd	103	27	(	(	-LRB-
cord-310268-8q4tk6fd	103	28	MARAS	MARAS	NNP
cord-310268-8q4tk6fd	103	29	)	)	-RRB-
cord-310268-8q4tk6fd	103	30	:	:	:
cord-310268-8q4tk6fd	104	1	The	the	DT
cord-310268-8q4tk6fd	104	2	target	target	NN
cord-310268-8q4tk6fd	104	3	-	-	HYPH
cord-310268-8q4tk6fd	104	4	coated	coat	VBN
cord-310268-8q4tk6fd	104	5	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	104	6	beads	bead	NNS
cord-310268-8q4tk6fd	104	7	are	be	VBP
cord-310268-8q4tk6fd	104	8	incubated	incubate	VBN
cord-310268-8q4tk6fd	104	9	with	with	IN
cord-310268-8q4tk6fd	104	10	the	the	DT
cord-310268-8q4tk6fd	104	11	ssDNA	ssdna	JJ
cord-310268-8q4tk6fd	104	12	pool	pool	NN
cord-310268-8q4tk6fd	104	13	.	.	.
cord-310268-8q4tk6fd	105	1	The	the	DT
cord-310268-8q4tk6fd	105	2	beads	bead	NNS
cord-310268-8q4tk6fd	105	3	with	with	IN
cord-310268-8q4tk6fd	105	4	bound	bound	JJ
cord-310268-8q4tk6fd	105	5	sequences	sequence	NNS
cord-310268-8q4tk6fd	105	6	are	be	VBP
cord-310268-8q4tk6fd	105	7	then	then	RB
cord-310268-8q4tk6fd	105	8	separated	separate	VBN
cord-310268-8q4tk6fd	105	9	from	from	IN
cord-310268-8q4tk6fd	105	10	the	the	DT
cord-310268-8q4tk6fd	105	11	unbound	unbound	JJ
cord-310268-8q4tk6fd	105	12	sequences	sequence	NNS
cord-310268-8q4tk6fd	105	13	with	with	IN
cord-310268-8q4tk6fd	105	14	a	a	DT
cord-310268-8q4tk6fd	105	15	U	u	NN
cord-310268-8q4tk6fd	105	16	-	-	HYPH
cord-310268-8q4tk6fd	105	17	shaped	shape	VBN
cord-310268-8q4tk6fd	105	18	magnet	magnet	NN
cord-310268-8q4tk6fd	105	19	or	or	CC
cord-310268-8q4tk6fd	105	20	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	105	21	stand	stand	NN
cord-310268-8q4tk6fd	105	22	.	.	.
cord-310268-8q4tk6fd	106	1	After	after	IN
cord-310268-8q4tk6fd	106	2	re	re	NN
cord-310268-8q4tk6fd	106	3	-	-	NN
cord-310268-8q4tk6fd	106	4	dispersion	dispersion	NN
cord-310268-8q4tk6fd	106	5	,	,	,
cord-310268-8q4tk6fd	106	6	the	the	DT
cord-310268-8q4tk6fd	106	7	beads	bead	NNS
cord-310268-8q4tk6fd	106	8	are	be	VBP
cord-310268-8q4tk6fd	106	9	put	put	VBN
cord-310268-8q4tk6fd	106	10	in	in	IN
cord-310268-8q4tk6fd	106	11	an	an	DT
cord-310268-8q4tk6fd	106	12	externally	externally	RB
cord-310268-8q4tk6fd	106	13	applied	apply	VBN
cord-310268-8q4tk6fd	106	14	rotating	rotate	VBG
cord-310268-8q4tk6fd	106	15	or	or	CC
cord-310268-8q4tk6fd	106	16	alternating	alternate	VBG
cord-310268-8q4tk6fd	106	17	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	106	18	field	field	NN
cord-310268-8q4tk6fd	106	19	.	.	.
cord-310268-8q4tk6fd	107	1	During	during	IN
cord-310268-8q4tk6fd	107	2	this	this	DT
cord-310268-8q4tk6fd	107	3	process	process	NN
cord-310268-8q4tk6fd	107	4	,	,	,
cord-310268-8q4tk6fd	107	5	the	the	DT
cord-310268-8q4tk6fd	107	6	weak	weak	JJ
cord-310268-8q4tk6fd	107	7	and	and	CC
cord-310268-8q4tk6fd	107	8	non	non	JJ
cord-310268-8q4tk6fd	107	9	-	-	JJ
cord-310268-8q4tk6fd	107	10	specific	specific	JJ
cord-310268-8q4tk6fd	107	11	binding	binding	NN
cord-310268-8q4tk6fd	107	12	sequences	sequence	NNS
cord-310268-8q4tk6fd	107	13	are	be	VBP
cord-310268-8q4tk6fd	107	14	released	release	VBN
cord-310268-8q4tk6fd	107	15	and	and	CC
cord-310268-8q4tk6fd	107	16	separated	separate	VBN
cord-310268-8q4tk6fd	107	17	.	.	.
cord-310268-8q4tk6fd	108	1	The	the	DT
cord-310268-8q4tk6fd	108	2	strong	strong	RB
cord-310268-8q4tk6fd	108	3	-	-	HYPH
cord-310268-8q4tk6fd	108	4	binding	bind	VBG
cord-310268-8q4tk6fd	108	5	sequences	sequence	NNS
cord-310268-8q4tk6fd	108	6	are	be	VBP
cord-310268-8q4tk6fd	108	7	finally	finally	RB
cord-310268-8q4tk6fd	108	8	released	release	VBN
cord-310268-8q4tk6fd	108	9	from	from	IN
cord-310268-8q4tk6fd	108	10	the	the	DT
cord-310268-8q4tk6fd	108	11	beads	bead	NNS
cord-310268-8q4tk6fd	108	12	by	by	IN
cord-310268-8q4tk6fd	108	13	heating	heating	NN
cord-310268-8q4tk6fd	108	14	and	and	CC
cord-310268-8q4tk6fd	108	15	then	then	RB
cord-310268-8q4tk6fd	108	16	incubated	incubate	VBN
cord-310268-8q4tk6fd	108	17	with	with	IN
cord-310268-8q4tk6fd	108	18	the	the	DT
cord-310268-8q4tk6fd	108	19	beads	bead	NNS
cord-310268-8q4tk6fd	108	20	without	without	IN
cord-310268-8q4tk6fd	108	21	a	a	DT
cord-310268-8q4tk6fd	108	22	target	target	NN
cord-310268-8q4tk6fd	108	23	for	for	IN
cord-310268-8q4tk6fd	108	24	the	the	DT
cord-310268-8q4tk6fd	108	25	negative	negative	JJ
cord-310268-8q4tk6fd	108	26	selection	selection	NN
cord-310268-8q4tk6fd	108	27	.	.	.
cord-310268-8q4tk6fd	109	1	The	the	DT
cord-310268-8q4tk6fd	109	2	selected	select	VBN
cord-310268-8q4tk6fd	109	3	sequences	sequence	NNS
cord-310268-8q4tk6fd	109	4	are	be	VBP
cord-310268-8q4tk6fd	109	5	amplified	amplify	VBN
cord-310268-8q4tk6fd	109	6	,	,	,
cord-310268-8q4tk6fd	109	7	cloned	clone	VBN
cord-310268-8q4tk6fd	109	8	and	and	CC
cord-310268-8q4tk6fd	109	9	sequenced	sequence	VBN
cord-310268-8q4tk6fd	109	10	as	as	IN
cord-310268-8q4tk6fd	109	11	usual	usual	JJ
cord-310268-8q4tk6fd	109	12	;	;	:
cord-310268-8q4tk6fd	109	13	(	(	-LRB-
cord-310268-8q4tk6fd	109	14	C	c	NN
cord-310268-8q4tk6fd	109	15	)	)	-RRB-
cord-310268-8q4tk6fd	109	16	One	one	CD
cord-310268-8q4tk6fd	109	17	-	-	HYPH
cord-310268-8q4tk6fd	109	18	step	step	NN
cord-310268-8q4tk6fd	109	19	Selection	selection	NN
cord-310268-8q4tk6fd	109	20	:	:	:
cord-310268-8q4tk6fd	110	1	A	a	DT
cord-310268-8q4tk6fd	110	2	FAM	FAM	NNP
cord-310268-8q4tk6fd	110	3	-	-	HYPH
cord-310268-8q4tk6fd	110	4	labeled	label	VBN
cord-310268-8q4tk6fd	110	5	oligonucleotide	oligonucleotide	JJ
cord-310268-8q4tk6fd	110	6	library	library	NN
cord-310268-8q4tk6fd	110	7	is	be	VBZ
cord-310268-8q4tk6fd	110	8	incubated	incubate	VBN
cord-310268-8q4tk6fd	110	9	with	with	IN
cord-310268-8q4tk6fd	110	10	a	a	DT
cord-310268-8q4tk6fd	110	11	target	target	NN
cord-310268-8q4tk6fd	110	12	immobilized	immobilize	VBN
cord-310268-8q4tk6fd	110	13	on	on	IN
cord-310268-8q4tk6fd	110	14	a	a	DT
cord-310268-8q4tk6fd	110	15	glass	glass	NN
cord-310268-8q4tk6fd	110	16	coverslip	coverslip	NN
cord-310268-8q4tk6fd	110	17	that	that	WDT
cord-310268-8q4tk6fd	110	18	was	be	VBD
cord-310268-8q4tk6fd	110	19	coated	coat	VBN
cord-310268-8q4tk6fd	110	20	with	with	IN
cord-310268-8q4tk6fd	110	21	N	n	NN
cord-310268-8q4tk6fd	110	22	-	-	HYPH
cord-310268-8q4tk6fd	110	23	hydroxysuccinimide	hydroxysuccinimide	NNP
cord-310268-8q4tk6fd	110	24	(	(	-LRB-
cord-310268-8q4tk6fd	110	25	NHS	NHS	NNP
cord-310268-8q4tk6fd	110	26	)	)	-RRB-
cord-310268-8q4tk6fd	110	27	functionalized	functionalize	VBD
cord-310268-8q4tk6fd	110	28	polyethylene	polyethylene	NN
cord-310268-8q4tk6fd	110	29	glycol	glycol	NN
cord-310268-8q4tk6fd	110	30	(	(	-LRB-
cord-310268-8q4tk6fd	110	31	PEG	PEG	NNP
cord-310268-8q4tk6fd	110	32	)	)	-RRB-
cord-310268-8q4tk6fd	110	33	.	.	.
cord-310268-8q4tk6fd	111	1	Unbound	unbound	JJ
cord-310268-8q4tk6fd	111	2	sequences	sequence	NNS
cord-310268-8q4tk6fd	111	3	are	be	VBP
cord-310268-8q4tk6fd	111	4	discarded	discard	VBN
cord-310268-8q4tk6fd	111	5	by	by	IN
cord-310268-8q4tk6fd	111	6	extensive	extensive	JJ
cord-310268-8q4tk6fd	111	7	washing	washing	NN
cord-310268-8q4tk6fd	111	8	followed	follow	VBN
cord-310268-8q4tk6fd	111	9	by	by	IN
cord-310268-8q4tk6fd	111	10	monitoring	monitor	VBG
cord-310268-8q4tk6fd	111	11	with	with	IN
cord-310268-8q4tk6fd	111	12	fluorescence	fluorescence	NN
cord-310268-8q4tk6fd	111	13	microscopy	microscopy	NN
cord-310268-8q4tk6fd	111	14	.	.	.
cord-310268-8q4tk6fd	112	1	The	the	DT
cord-310268-8q4tk6fd	112	2	coverslip	coverslip	NN
cord-310268-8q4tk6fd	112	3	is	be	VBZ
cord-310268-8q4tk6fd	112	4	later	later	RB
cord-310268-8q4tk6fd	112	5	crushed	crush	VBN
cord-310268-8q4tk6fd	112	6	and	and	CC
cord-310268-8q4tk6fd	112	7	the	the	DT
cord-310268-8q4tk6fd	112	8	bound	bound	JJ
cord-310268-8q4tk6fd	112	9	sequences	sequence	NNS
cord-310268-8q4tk6fd	112	10	are	be	VBP
cord-310268-8q4tk6fd	112	11	eluted	elute	VBN
cord-310268-8q4tk6fd	112	12	by	by	IN
cord-310268-8q4tk6fd	112	13	heating	heat	VBG
cord-310268-8q4tk6fd	112	14	in	in	IN
cord-310268-8q4tk6fd	112	15	water	water	NN
cord-310268-8q4tk6fd	112	16	.	.	.
cord-310268-8q4tk6fd	113	1	The	the	DT
cord-310268-8q4tk6fd	113	2	selected	select	VBN
cord-310268-8q4tk6fd	113	3	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	113	4	are	be	VBP
cord-310268-8q4tk6fd	113	5	amplified	amplify	VBN
cord-310268-8q4tk6fd	113	6	,	,	,
cord-310268-8q4tk6fd	113	7	cloned	clone	VBN
cord-310268-8q4tk6fd	113	8	and	and	CC
cord-310268-8q4tk6fd	113	9	sequenced	sequence	VBN
cord-310268-8q4tk6fd	113	10	as	as	IN
cord-310268-8q4tk6fd	113	11	usual	usual	JJ
cord-310268-8q4tk6fd	113	12	.	.	.
cord-310268-8q4tk6fd	114	1	DNA	DNA	NNP
cord-310268-8q4tk6fd	114	2	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	114	3	are	be	VBP
cord-310268-8q4tk6fd	114	4	well	well	RB
cord-310268-8q4tk6fd	114	5	known	know	VBN
cord-310268-8q4tk6fd	114	6	to	to	TO
cord-310268-8q4tk6fd	114	7	be	be	VB
cord-310268-8q4tk6fd	114	8	more	more	RBR
cord-310268-8q4tk6fd	114	9	stable	stable	JJ
cord-310268-8q4tk6fd	114	10	than	than	IN
cord-310268-8q4tk6fd	114	11	RNA	RNA	NNP
cord-310268-8q4tk6fd	114	12	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	114	13	,	,	,
cord-310268-8q4tk6fd	114	14	which	which	WDT
cord-310268-8q4tk6fd	114	15	allows	allow	VBZ
cord-310268-8q4tk6fd	114	16	them	-PRON-	PRP
cord-310268-8q4tk6fd	114	17	to	to	TO
cord-310268-8q4tk6fd	114	18	be	be	VB
cord-310268-8q4tk6fd	114	19	readily	readily	RB
cord-310268-8q4tk6fd	114	20	used	use	VBN
cord-310268-8q4tk6fd	114	21	in	in	IN
cord-310268-8q4tk6fd	114	22	the	the	DT
cord-310268-8q4tk6fd	114	23	primary	primary	JJ
cord-310268-8q4tk6fd	114	24	stage	stage	NN
cord-310268-8q4tk6fd	114	25	of	of	IN
cord-310268-8q4tk6fd	114	26	developing	develop	VBG
cord-310268-8q4tk6fd	114	27	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	114	28	tools	tool	NNS
cord-310268-8q4tk6fd	114	29	.	.	.
cord-310268-8q4tk6fd	115	1	However	however	RB
cord-310268-8q4tk6fd	115	2	,	,	,
cord-310268-8q4tk6fd	115	3	the	the	DT
cord-310268-8q4tk6fd	115	4	degradation	degradation	NN
cord-310268-8q4tk6fd	115	5	of	of	IN
cord-310268-8q4tk6fd	115	6	DNA	dna	NN
cord-310268-8q4tk6fd	115	7	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	115	8	by	by	IN
cord-310268-8q4tk6fd	115	9	nuclease	nuclease	NNP
cord-310268-8q4tk6fd	115	10	is	be	VBZ
cord-310268-8q4tk6fd	115	11	still	still	RB
cord-310268-8q4tk6fd	115	12	a	a	DT
cord-310268-8q4tk6fd	115	13	serious	serious	JJ
cord-310268-8q4tk6fd	115	14	problem	problem	NN
cord-310268-8q4tk6fd	115	15	that	that	WDT
cord-310268-8q4tk6fd	115	16	limits	limit	VBZ
cord-310268-8q4tk6fd	115	17	their	-PRON-	PRP$
cord-310268-8q4tk6fd	115	18	clinical	clinical	JJ
cord-310268-8q4tk6fd	115	19	application	application	NN
cord-310268-8q4tk6fd	115	20	,	,	,
cord-310268-8q4tk6fd	115	21	when	when	WRB
cord-310268-8q4tk6fd	115	22	they	-PRON-	PRP
cord-310268-8q4tk6fd	115	23	are	be	VBP
cord-310268-8q4tk6fd	115	24	subjected	subject	VBN
cord-310268-8q4tk6fd	115	25	to	to	IN
cord-310268-8q4tk6fd	115	26	complicated	complicated	JJ
cord-310268-8q4tk6fd	115	27	biological	biological	JJ
cord-310268-8q4tk6fd	115	28	samples	sample	NNS
cord-310268-8q4tk6fd	115	29	.	.	.
cord-310268-8q4tk6fd	116	1	To	to	TO
cord-310268-8q4tk6fd	116	2	improve	improve	VB
cord-310268-8q4tk6fd	116	3	the	the	DT
cord-310268-8q4tk6fd	116	4	nuclease	nuclease	NN
cord-310268-8q4tk6fd	116	5	resistance	resistance	NN
cord-310268-8q4tk6fd	116	6	of	of	IN
cord-310268-8q4tk6fd	116	7	DNA	dna	NN
cord-310268-8q4tk6fd	116	8	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	116	9	,	,	,
cord-310268-8q4tk6fd	116	10	one	one	CD
cord-310268-8q4tk6fd	116	11	of	of	IN
cord-310268-8q4tk6fd	116	12	the	the	DT
cord-310268-8q4tk6fd	116	13	effective	effective	JJ
cord-310268-8q4tk6fd	116	14	solutions	solution	NNS
cord-310268-8q4tk6fd	116	15	is	be	VBZ
cord-310268-8q4tk6fd	116	16	to	to	TO
cord-310268-8q4tk6fd	116	17	use	use	VB
cord-310268-8q4tk6fd	116	18	a	a	DT
cord-310268-8q4tk6fd	116	19	library	library	NN
cord-310268-8q4tk6fd	116	20	with	with	IN
cord-310268-8q4tk6fd	116	21	chemically	chemically	RB
cord-310268-8q4tk6fd	116	22	modified	modify	VBN
cord-310268-8q4tk6fd	116	23	DNA	dna	NN
cord-310268-8q4tk6fd	116	24	sequences	sequence	NNS
cord-310268-8q4tk6fd	116	25	in	in	IN
cord-310268-8q4tk6fd	116	26	the	the	DT
cord-310268-8q4tk6fd	116	27	screening	screening	NN
cord-310268-8q4tk6fd	116	28	process	process	NN
cord-310268-8q4tk6fd	116	29	.	.	.
cord-310268-8q4tk6fd	117	1	The	the	DT
cord-310268-8q4tk6fd	117	2	modified	modify	VBN
cord-310268-8q4tk6fd	117	3	DNA	dna	NN
cord-310268-8q4tk6fd	117	4	library	library	NN
cord-310268-8q4tk6fd	117	5	can	can	MD
cord-310268-8q4tk6fd	117	6	be	be	VB
cord-310268-8q4tk6fd	117	7	prepared	prepare	VBN
cord-310268-8q4tk6fd	117	8	by	by	IN
cord-310268-8q4tk6fd	117	9	PCR	PCR	NNP
cord-310268-8q4tk6fd	117	10	amplification	amplification	NN
cord-310268-8q4tk6fd	117	11	using	use	VBG
cord-310268-8q4tk6fd	117	12	specific	specific	JJ
cord-310268-8q4tk6fd	117	13	polymerase	polymerase	NN
cord-310268-8q4tk6fd	117	14	and	and	CC
cord-310268-8q4tk6fd	117	15	catalysis	catalysis	NN
cord-310268-8q4tk6fd	117	16	reactions	reaction	NNS
cord-310268-8q4tk6fd	117	17	using	use	VBG
cord-310268-8q4tk6fd	117	18	modified	modify	VBN
cord-310268-8q4tk6fd	117	19	DNA	dna	NN
cord-310268-8q4tk6fd	117	20	enzymes	enzyme	NNS
cord-310268-8q4tk6fd	117	21	[	[	-LRB-
cord-310268-8q4tk6fd	117	22	37	37	CD
cord-310268-8q4tk6fd	117	23	,	,	,
cord-310268-8q4tk6fd	117	24	38	38	CD
cord-310268-8q4tk6fd	117	25	]	]	-RRB-
cord-310268-8q4tk6fd	117	26	.	.	.
cord-310268-8q4tk6fd	118	1	Modification	modification	NN
cord-310268-8q4tk6fd	118	2	of	of	IN
cord-310268-8q4tk6fd	118	3	the	the	DT
cord-310268-8q4tk6fd	118	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	118	5	can	can	MD
cord-310268-8q4tk6fd	118	6	also	also	RB
cord-310268-8q4tk6fd	118	7	be	be	VB
cord-310268-8q4tk6fd	118	8	performed	perform	VBN
cord-310268-8q4tk6fd	118	9	after	after	IN
cord-310268-8q4tk6fd	118	10	the	the	DT
cord-310268-8q4tk6fd	118	11	in	in	FW
cord-310268-8q4tk6fd	118	12	vitro	vitro	FW
cord-310268-8q4tk6fd	118	13	selection	selection	NN
cord-310268-8q4tk6fd	118	14	from	from	IN
cord-310268-8q4tk6fd	118	15	natural	natural	JJ
cord-310268-8q4tk6fd	118	16	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	118	17	acid	acid	NN
cord-310268-8q4tk6fd	118	18	library	library	NN
cord-310268-8q4tk6fd	118	19	.	.	.
cord-310268-8q4tk6fd	119	1	Modifications	modification	NNS
cord-310268-8q4tk6fd	119	2	of	of	IN
cord-310268-8q4tk6fd	119	3	the	the	DT
cord-310268-8q4tk6fd	119	4	sugar	sugar	NN
cord-310268-8q4tk6fd	119	5	phosphate	phosphate	NN
cord-310268-8q4tk6fd	119	6	backbone	backbone	NN
cord-310268-8q4tk6fd	119	7	or	or	CC
cord-310268-8q4tk6fd	119	8	the	the	DT
cord-310268-8q4tk6fd	119	9	pyrimidine	pyrimidine	NN
cord-310268-8q4tk6fd	119	10	are	be	VBP
cord-310268-8q4tk6fd	119	11	the	the	DT
cord-310268-8q4tk6fd	119	12	strategies	strategy	NNS
cord-310268-8q4tk6fd	119	13	used	use	VBN
cord-310268-8q4tk6fd	119	14	to	to	TO
cord-310268-8q4tk6fd	119	15	increase	increase	VB
cord-310268-8q4tk6fd	119	16	the	the	DT
cord-310268-8q4tk6fd	119	17	stability	stability	NN
cord-310268-8q4tk6fd	119	18	and	and	CC
cord-310268-8q4tk6fd	119	19	nuclease	nuclease	NN
cord-310268-8q4tk6fd	119	20	resistance	resistance	NN
cord-310268-8q4tk6fd	119	21	of	of	IN
cord-310268-8q4tk6fd	119	22	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	119	23	[	[	-LRB-
cord-310268-8q4tk6fd	119	24	38	38	CD
cord-310268-8q4tk6fd	119	25	]	]	-RRB-
cord-310268-8q4tk6fd	119	26	[	[	-LRB-
cord-310268-8q4tk6fd	119	27	39	39	CD
cord-310268-8q4tk6fd	119	28	]	]	-RRB-
cord-310268-8q4tk6fd	119	29	[	[	-LRB-
cord-310268-8q4tk6fd	119	30	40	40	CD
cord-310268-8q4tk6fd	119	31	]	]	-RRB-
cord-310268-8q4tk6fd	119	32	.	.	.
cord-310268-8q4tk6fd	120	1	Capping	cap	VBG
cord-310268-8q4tk6fd	120	2	the	the	DT
cord-310268-8q4tk6fd	120	3	end	end	NN
cord-310268-8q4tk6fd	120	4	of	of	IN
cord-310268-8q4tk6fd	120	5	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	120	6	is	be	VBZ
cord-310268-8q4tk6fd	120	7	also	also	RB
cord-310268-8q4tk6fd	120	8	utilized	utilize	VBN
cord-310268-8q4tk6fd	120	9	to	to	TO
cord-310268-8q4tk6fd	120	10	enhance	enhance	VB
cord-310268-8q4tk6fd	120	11	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	120	12	stability	stability	NN
cord-310268-8q4tk6fd	120	13	against	against	IN
cord-310268-8q4tk6fd	120	14	nucleases	nuclease	NNS
cord-310268-8q4tk6fd	120	15	[	[	-LRB-
cord-310268-8q4tk6fd	120	16	41	41	CD
cord-310268-8q4tk6fd	120	17	]	]	-RRB-
cord-310268-8q4tk6fd	120	18	.	.	.
cord-310268-8q4tk6fd	121	1	Incorporation	incorporation	NN
cord-310268-8q4tk6fd	121	2	of	of	IN
cord-310268-8q4tk6fd	121	3	unnatural	unnatural	JJ
cord-310268-8q4tk6fd	121	4	nucleotides	nucleotide	NNS
cord-310268-8q4tk6fd	121	5	is	be	VBZ
cord-310268-8q4tk6fd	121	6	another	another	DT
cord-310268-8q4tk6fd	121	7	approach	approach	NN
cord-310268-8q4tk6fd	121	8	to	to	TO
cord-310268-8q4tk6fd	121	9	overcome	overcome	VB
cord-310268-8q4tk6fd	121	10	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	121	11	instability	instability	NN
cord-310268-8q4tk6fd	121	12	.	.	.
cord-310268-8q4tk6fd	122	1	Locked	lock	VBN
cord-310268-8q4tk6fd	122	2	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	122	3	acid	acid	NN
cord-310268-8q4tk6fd	122	4	(	(	-LRB-
cord-310268-8q4tk6fd	122	5	LNA	LNA	NNP
cord-310268-8q4tk6fd	122	6	)	)	-RRB-
cord-310268-8q4tk6fd	122	7	is	be	VBZ
cord-310268-8q4tk6fd	122	8	one	one	CD
cord-310268-8q4tk6fd	122	9	of	of	IN
cord-310268-8q4tk6fd	122	10	the	the	DT
cord-310268-8q4tk6fd	122	11	most	most	RBS
cord-310268-8q4tk6fd	122	12	prominent	prominent	JJ
cord-310268-8q4tk6fd	122	13	and	and	CC
cord-310268-8q4tk6fd	122	14	successful	successful	JJ
cord-310268-8q4tk6fd	122	15	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	122	16	acid	acid	NN
cord-310268-8q4tk6fd	122	17	analogues	analogue	NNS
cord-310268-8q4tk6fd	122	18	because	because	IN
cord-310268-8q4tk6fd	122	19	of	of	IN
cord-310268-8q4tk6fd	122	20	their	-PRON-	PRP$
cord-310268-8q4tk6fd	122	21	pronounced	pronounce	VBN
cord-310268-8q4tk6fd	122	22	stability	stability	NN
cord-310268-8q4tk6fd	122	23	[	[	-LRB-
cord-310268-8q4tk6fd	122	24	42	42	CD
cord-310268-8q4tk6fd	122	25	]	]	-RRB-
cord-310268-8q4tk6fd	122	26	[	[	-LRB-
cord-310268-8q4tk6fd	122	27	43	43	CD
cord-310268-8q4tk6fd	122	28	]	]	-RRB-
cord-310268-8q4tk6fd	122	29	[	[	-LRB-
cord-310268-8q4tk6fd	122	30	44	44	CD
cord-310268-8q4tk6fd	122	31	]	]	-RRB-
cord-310268-8q4tk6fd	122	32	.	.	.
cord-310268-8q4tk6fd	123	1	Generation	generation	NN
cord-310268-8q4tk6fd	123	2	of	of	IN
cord-310268-8q4tk6fd	123	3	"	"	``
cord-310268-8q4tk6fd	123	4	mirror	mirror	NNP
cord-310268-8q4tk6fd	123	5	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	123	6	"	"	''
cord-310268-8q4tk6fd	123	7	,	,	,
cord-310268-8q4tk6fd	123	8	which	which	WDT
cord-310268-8q4tk6fd	123	9	are	be	VBP
cord-310268-8q4tk6fd	123	10	also	also	RB
cord-310268-8q4tk6fd	123	11	known	know	VBN
cord-310268-8q4tk6fd	123	12	as	as	IN
cord-310268-8q4tk6fd	123	13	spiegelmers	spiegelmer	NNS
cord-310268-8q4tk6fd	123	14	,	,	,
cord-310268-8q4tk6fd	123	15	is	be	VBZ
cord-310268-8q4tk6fd	123	16	another	another	DT
cord-310268-8q4tk6fd	123	17	approach	approach	NN
cord-310268-8q4tk6fd	123	18	to	to	TO
cord-310268-8q4tk6fd	123	19	improve	improve	VB
cord-310268-8q4tk6fd	123	20	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	123	21	stability	stability	NN
cord-310268-8q4tk6fd	123	22	against	against	IN
cord-310268-8q4tk6fd	123	23	nucleases	nuclease	NNS
cord-310268-8q4tk6fd	123	24	[	[	-LRB-
cord-310268-8q4tk6fd	123	25	45	45	CD
cord-310268-8q4tk6fd	123	26	]	]	-RRB-
cord-310268-8q4tk6fd	123	27	.	.	.
cord-310268-8q4tk6fd	124	1	Generation	generation	NN
cord-310268-8q4tk6fd	124	2	of	of	IN
cord-310268-8q4tk6fd	124	3	highly	highly	RB
cord-310268-8q4tk6fd	124	4	specific	specific	JJ
cord-310268-8q4tk6fd	124	5	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	124	6	with	with	IN
cord-310268-8q4tk6fd	124	7	a	a	DT
cord-310268-8q4tk6fd	124	8	long	long	JJ
cord-310268-8q4tk6fd	124	9	lifetime	lifetime	NN
cord-310268-8q4tk6fd	124	10	is	be	VBZ
cord-310268-8q4tk6fd	124	11	very	very	RB
cord-310268-8q4tk6fd	124	12	important	important	JJ
cord-310268-8q4tk6fd	124	13	for	for	IN
cord-310268-8q4tk6fd	124	14	their	-PRON-	PRP$
cord-310268-8q4tk6fd	124	15	therapeutic	therapeutic	JJ
cord-310268-8q4tk6fd	124	16	application	application	NN
cord-310268-8q4tk6fd	124	17	.	.	.
cord-310268-8q4tk6fd	125	1	Because	because	IN
cord-310268-8q4tk6fd	125	2	most	most	JJS
cord-310268-8q4tk6fd	125	3	DNA	dna	NN
cord-310268-8q4tk6fd	125	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	125	5	have	have	VBP
cord-310268-8q4tk6fd	125	6	a	a	DT
cord-310268-8q4tk6fd	125	7	small	small	JJ
cord-310268-8q4tk6fd	125	8	molecular	molecular	JJ
cord-310268-8q4tk6fd	125	9	weight	weight	NN
cord-310268-8q4tk6fd	125	10	(	(	-LRB-
cord-310268-8q4tk6fd	125	11	ranging	range	VBG
cord-310268-8q4tk6fd	125	12	from	from	IN
cord-310268-8q4tk6fd	125	13	5	5	CD
cord-310268-8q4tk6fd	125	14	-	-	SYM
cord-310268-8q4tk6fd	125	15	15	15	CD
cord-310268-8q4tk6fd	125	16	kDa	kDa	NNPS
cord-310268-8q4tk6fd	125	17	)	)	-RRB-
cord-310268-8q4tk6fd	125	18	,	,	,
cord-310268-8q4tk6fd	125	19	DNA	DNA	NNP
cord-310268-8q4tk6fd	125	20	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	125	21	are	be	VBP
cord-310268-8q4tk6fd	125	22	readily	readily	RB
cord-310268-8q4tk6fd	125	23	removed	remove	VBN
cord-310268-8q4tk6fd	125	24	via	via	IN
cord-310268-8q4tk6fd	125	25	renal	renal	JJ
cord-310268-8q4tk6fd	125	26	filtration	filtration	NN
cord-310268-8q4tk6fd	125	27	and	and	CC
cord-310268-8q4tk6fd	125	28	metabolic	metabolic	JJ
cord-310268-8q4tk6fd	125	29	processes	process	NNS
cord-310268-8q4tk6fd	125	30	,	,	,
cord-310268-8q4tk6fd	125	31	limiting	limit	VBG
cord-310268-8q4tk6fd	125	32	their	-PRON-	PRP$
cord-310268-8q4tk6fd	125	33	therapeutic	therapeutic	JJ
cord-310268-8q4tk6fd	125	34	application	application	NN
cord-310268-8q4tk6fd	125	35	.	.	.
cord-310268-8q4tk6fd	126	1	One	one	CD
cord-310268-8q4tk6fd	126	2	of	of	IN
cord-310268-8q4tk6fd	126	3	the	the	DT
cord-310268-8q4tk6fd	126	4	effective	effective	JJ
cord-310268-8q4tk6fd	126	5	ways	way	NNS
cord-310268-8q4tk6fd	126	6	to	to	TO
cord-310268-8q4tk6fd	126	7	control	control	VB
cord-310268-8q4tk6fd	126	8	the	the	DT
cord-310268-8q4tk6fd	126	9	lifetime	lifetime	NN
cord-310268-8q4tk6fd	126	10	of	of	IN
cord-310268-8q4tk6fd	126	11	DNA	DNA	NNP
cord-310268-8q4tk6fd	126	12	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	126	13	in	in	IN
cord-310268-8q4tk6fd	126	14	vivo	vivo	NNP
cord-310268-8q4tk6fd	126	15	is	be	VBZ
cord-310268-8q4tk6fd	126	16	to	to	TO
cord-310268-8q4tk6fd	126	17	conjugate	conjugate	VB
cord-310268-8q4tk6fd	126	18	the	the	DT
cord-310268-8q4tk6fd	126	19	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	126	20	with	with	IN
cord-310268-8q4tk6fd	126	21	bioavailable	bioavailable	JJ
cord-310268-8q4tk6fd	126	22	materials	material	NNS
cord-310268-8q4tk6fd	126	23	.	.	.
cord-310268-8q4tk6fd	127	1	Conjugation	conjugation	NN
cord-310268-8q4tk6fd	127	2	of	of	IN
cord-310268-8q4tk6fd	127	3	DNA	dna	NN
cord-310268-8q4tk6fd	127	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	127	5	with	with	IN
cord-310268-8q4tk6fd	127	6	polyethylene	polyethylene	NN
cord-310268-8q4tk6fd	127	7	glycol	glycol	NN
cord-310268-8q4tk6fd	127	8	(	(	-LRB-
cord-310268-8q4tk6fd	127	9	PEG	PEG	NNP
cord-310268-8q4tk6fd	127	10	)	)	-RRB-
cord-310268-8q4tk6fd	127	11	is	be	VBZ
cord-310268-8q4tk6fd	127	12	commonly	commonly	RB
cord-310268-8q4tk6fd	127	13	used	use	VBN
cord-310268-8q4tk6fd	127	14	to	to	TO
cord-310268-8q4tk6fd	127	15	prolong	prolong	VB
cord-310268-8q4tk6fd	127	16	their	-PRON-	PRP$
cord-310268-8q4tk6fd	127	17	circulation	circulation	NN
cord-310268-8q4tk6fd	127	18	in	in	IN
cord-310268-8q4tk6fd	127	19	the	the	DT
cord-310268-8q4tk6fd	127	20	bloodstream	bloodstream	NN
cord-310268-8q4tk6fd	127	21	[	[	-LRB-
cord-310268-8q4tk6fd	127	22	46	46	CD
cord-310268-8q4tk6fd	127	23	,	,	,
cord-310268-8q4tk6fd	127	24	47	47	CD
cord-310268-8q4tk6fd	127	25	]	]	-RRB-
cord-310268-8q4tk6fd	127	26	.	.	.
cord-310268-8q4tk6fd	128	1	Coating	coating	NN
cord-310268-8q4tk6fd	128	2	DNA	DNA	NNP
cord-310268-8q4tk6fd	128	3	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	128	4	with	with	IN
cord-310268-8q4tk6fd	128	5	other	other	JJ
cord-310268-8q4tk6fd	128	6	nanomaterials	nanomaterial	NNS
cord-310268-8q4tk6fd	128	7	such	such	JJ
cord-310268-8q4tk6fd	128	8	as	as	IN
cord-310268-8q4tk6fd	128	9	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	128	10	[	[	-LRB-
cord-310268-8q4tk6fd	128	11	48	48	CD
cord-310268-8q4tk6fd	128	12	,	,	,
cord-310268-8q4tk6fd	128	13	49	49	CD
cord-310268-8q4tk6fd	128	14	]	]	-RRB-
cord-310268-8q4tk6fd	128	15	,	,	,
cord-310268-8q4tk6fd	128	16	liposomes	liposome	VBZ
cord-310268-8q4tk6fd	128	17	[	[	-LRB-
cord-310268-8q4tk6fd	128	18	50	50	CD
cord-310268-8q4tk6fd	128	19	]	]	-RRB-
cord-310268-8q4tk6fd	128	20	and	and	CC
cord-310268-8q4tk6fd	128	21	copolymers	copolymer	NNS
cord-310268-8q4tk6fd	128	22	[	[	-LRB-
cord-310268-8q4tk6fd	128	23	51	51	CD
cord-310268-8q4tk6fd	128	24	]	]	-RRB-
cord-310268-8q4tk6fd	128	25	has	have	VBZ
cord-310268-8q4tk6fd	128	26	been	be	VBN
cord-310268-8q4tk6fd	128	27	successfully	successfully	RB
cord-310268-8q4tk6fd	128	28	used	use	VBN
cord-310268-8q4tk6fd	128	29	to	to	TO
cord-310268-8q4tk6fd	128	30	improve	improve	VB
cord-310268-8q4tk6fd	128	31	the	the	DT
cord-310268-8q4tk6fd	128	32	lifetime	lifetime	NN
cord-310268-8q4tk6fd	128	33	of	of	IN
cord-310268-8q4tk6fd	128	34	DNA	DNA	NNP
cord-310268-8q4tk6fd	128	35	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	128	36	.	.	.
cord-310268-8q4tk6fd	129	1	Once	once	RB
cord-310268-8q4tk6fd	129	2	selected	select	VBN
cord-310268-8q4tk6fd	129	3	to	to	TO
cord-310268-8q4tk6fd	129	4	bind	bind	VB
cord-310268-8q4tk6fd	129	5	to	to	IN
cord-310268-8q4tk6fd	129	6	disease	disease	NN
cord-310268-8q4tk6fd	129	7	-	-	HYPH
cord-310268-8q4tk6fd	129	8	related	relate	VBN
cord-310268-8q4tk6fd	129	9	biomarkers	biomarker	NNS
cord-310268-8q4tk6fd	129	10	or	or	CC
cord-310268-8q4tk6fd	129	11	pathogens	pathogen	NNS
cord-310268-8q4tk6fd	129	12	,	,	,
cord-310268-8q4tk6fd	129	13	DNA	dna	NN
cord-310268-8q4tk6fd	129	14	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	129	15	can	can	MD
cord-310268-8q4tk6fd	129	16	be	be	VB
cord-310268-8q4tk6fd	129	17	developed	develop	VBN
cord-310268-8q4tk6fd	129	18	as	as	IN
cord-310268-8q4tk6fd	129	19	biosensors	biosensor	NNS
cord-310268-8q4tk6fd	129	20	through	through	IN
cord-310268-8q4tk6fd	129	21	chemical	chemical	JJ
cord-310268-8q4tk6fd	129	22	modification	modification	NN
cord-310268-8q4tk6fd	129	23	with	with	IN
cord-310268-8q4tk6fd	129	24	luminophores	luminophore	NNS
cord-310268-8q4tk6fd	129	25	or	or	CC
cord-310268-8q4tk6fd	129	26	linkage	linkage	NN
cord-310268-8q4tk6fd	129	27	to	to	IN
cord-310268-8q4tk6fd	129	28	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	129	29	in	in	IN
cord-310268-8q4tk6fd	129	30	various	various	JJ
cord-310268-8q4tk6fd	129	31	formats	format	NNS
cord-310268-8q4tk6fd	129	32	[	[	-LRB-
cord-310268-8q4tk6fd	129	33	52	52	CD
cord-310268-8q4tk6fd	129	34	]	]	-RRB-
cord-310268-8q4tk6fd	129	35	.	.	.
cord-310268-8q4tk6fd	130	1	For	for	IN
cord-310268-8q4tk6fd	130	2	example	example	NN
cord-310268-8q4tk6fd	130	3	,	,	,
cord-310268-8q4tk6fd	130	4	in	in	IN
cord-310268-8q4tk6fd	130	5	an	an	DT
cord-310268-8q4tk6fd	130	6	earlier	early	JJR
cord-310268-8q4tk6fd	130	7	study	study	NN
cord-310268-8q4tk6fd	130	8	,	,	,
cord-310268-8q4tk6fd	130	9	DNA	DNA	NNP
cord-310268-8q4tk6fd	130	10	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	130	11	selected	select	VBN
cord-310268-8q4tk6fd	130	12	for	for	IN
cord-310268-8q4tk6fd	130	13	Bacillus	Bacillus	NNP
cord-310268-8q4tk6fd	130	14	anthracic	anthracic	NN
cord-310268-8q4tk6fd	130	15	spores	spore	NNS
cord-310268-8q4tk6fd	130	16	were	be	VBD
cord-310268-8q4tk6fd	130	17	developed	develop	VBN
cord-310268-8q4tk6fd	130	18	to	to	TO
cord-310268-8q4tk6fd	130	19	detect	detect	VB
cord-310268-8q4tk6fd	130	20	anthrax	anthrax	NN
cord-310268-8q4tk6fd	130	21	spores	spore	NNS
cord-310268-8q4tk6fd	130	22	in	in	IN
cord-310268-8q4tk6fd	130	23	an	an	DT
cord-310268-8q4tk6fd	130	24	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	130	25	-	-	HYPH
cord-310268-8q4tk6fd	130	26	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	130	27	bead	bead	NN
cord-310268-8q4tk6fd	130	28	-	-	HYPH
cord-310268-8q4tk6fd	130	29	electrochemiluminescence	electrochemiluminescence	NN
cord-310268-8q4tk6fd	130	30	(	(	-LRB-
cord-310268-8q4tk6fd	130	31	AM	AM	NNP
cord-310268-8q4tk6fd	130	32	-	-	HYPH
cord-310268-8q4tk6fd	130	33	ECL	ECL	NNP
cord-310268-8q4tk6fd	130	34	)	)	-RRB-
cord-310268-8q4tk6fd	130	35	sandwich	sandwich	NN
cord-310268-8q4tk6fd	130	36	mode	mode	NN
cord-310268-8q4tk6fd	130	37	[	[	-LRB-
cord-310268-8q4tk6fd	130	38	53	53	CD
cord-310268-8q4tk6fd	130	39	]	]	-RRB-
cord-310268-8q4tk6fd	130	40	.	.	.
cord-310268-8q4tk6fd	131	1	The	the	DT
cord-310268-8q4tk6fd	131	2	Dynal	Dynal	NNP
cord-310268-8q4tk6fd	131	3	M-280	m-280	NN
cord-310268-8q4tk6fd	131	4	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	131	5	beads	bead	NNS
cord-310268-8q4tk6fd	131	6	were	be	VBD
cord-310268-8q4tk6fd	131	7	covered	cover	VBN
cord-310268-8q4tk6fd	131	8	with	with	IN
cord-310268-8q4tk6fd	131	9	the	the	DT
cord-310268-8q4tk6fd	131	10	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	131	11	and	and	CC
cord-310268-8q4tk6fd	131	12	used	use	VBN
cord-310268-8q4tk6fd	131	13	as	as	IN
cord-310268-8q4tk6fd	131	14	the	the	DT
cord-310268-8q4tk6fd	131	15	capturer	capturer	NN
cord-310268-8q4tk6fd	131	16	to	to	TO
cord-310268-8q4tk6fd	131	17	capture	capture	VB
cord-310268-8q4tk6fd	131	18	the	the	DT
cord-310268-8q4tk6fd	131	19	spores	spore	NNS
cord-310268-8q4tk6fd	131	20	,	,	,
cord-310268-8q4tk6fd	131	21	while	while	IN
cord-310268-8q4tk6fd	131	22	another	another	DT
cord-310268-8q4tk6fd	131	23	biotinylated	biotinylated	JJ
cord-310268-8q4tk6fd	131	24	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	131	25	was	be	VBD
cord-310268-8q4tk6fd	131	26	used	use	VBN
cord-310268-8q4tk6fd	131	27	as	as	IN
cord-310268-8q4tk6fd	131	28	the	the	DT
cord-310268-8q4tk6fd	131	29	reporter	reporter	NN
cord-310268-8q4tk6fd	131	30	and	and	CC
cord-310268-8q4tk6fd	131	31	the	the	DT
cord-310268-8q4tk6fd	131	32	signal	signal	NN
cord-310268-8q4tk6fd	131	33	was	be	VBD
cord-310268-8q4tk6fd	131	34	finally	finally	RB
cord-310268-8q4tk6fd	131	35	transduced	transduce	VBN
cord-310268-8q4tk6fd	131	36	through	through	IN
cord-310268-8q4tk6fd	131	37	the	the	DT
cord-310268-8q4tk6fd	131	38	streptavidin	streptavidin	NN
cord-310268-8q4tk6fd	131	39	-	-	HYPH
cord-310268-8q4tk6fd	131	40	Ru(bpy	ru(bpy	ADD
cord-310268-8q4tk6fd	131	41	)	)	-RRB-
cord-310268-8q4tk6fd	132	1	3	3	CD
cord-310268-8q4tk6fd	132	2	2	2	CD
cord-310268-8q4tk6fd	132	3	+	+	CD
cord-310268-8q4tk6fd	132	4	ECL	ECL	NNP
cord-310268-8q4tk6fd	132	5	.	.	.
cord-310268-8q4tk6fd	133	1	Since	since	IN
cord-310268-8q4tk6fd	133	2	the	the	DT
cord-310268-8q4tk6fd	133	3	first	first	JJ
cord-310268-8q4tk6fd	133	4	DNA	DNA	NNP
cord-310268-8q4tk6fd	133	5	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	133	6	was	be	VBD
cord-310268-8q4tk6fd	133	7	selected	select	VBN
cord-310268-8q4tk6fd	133	8	,	,	,
cord-310268-8q4tk6fd	133	9	dozens	dozen	NNS
cord-310268-8q4tk6fd	133	10	of	of	IN
cord-310268-8q4tk6fd	133	11	DNA	dna	NN
cord-310268-8q4tk6fd	133	12	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	133	13	have	have	VBP
cord-310268-8q4tk6fd	133	14	been	be	VBN
cord-310268-8q4tk6fd	133	15	selected	select	VBN
cord-310268-8q4tk6fd	133	16	for	for	IN
cord-310268-8q4tk6fd	133	17	the	the	DT
cord-310268-8q4tk6fd	133	18	use	use	NN
cord-310268-8q4tk6fd	133	19	of	of	IN
cord-310268-8q4tk6fd	133	20	disease	disease	NN
cord-310268-8q4tk6fd	133	21	-	-	HYPH
cord-310268-8q4tk6fd	133	22	related	relate	VBN
cord-310268-8q4tk6fd	133	23	detection	detection	NN
cord-310268-8q4tk6fd	133	24	.	.	.
cord-310268-8q4tk6fd	134	1	Although	although	IN
cord-310268-8q4tk6fd	134	2	there	there	EX
cord-310268-8q4tk6fd	134	3	are	be	VBP
cord-310268-8q4tk6fd	134	4	no	no	DT
cord-310268-8q4tk6fd	134	5	aptamer	aptamer	NN
cord-310268-8q4tk6fd	134	6	-	-	HYPH
cord-310268-8q4tk6fd	134	7	based	base	VBN
cord-310268-8q4tk6fd	134	8	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	134	9	tools	tool	NNS
cord-310268-8q4tk6fd	134	10	that	that	WDT
cord-310268-8q4tk6fd	134	11	are	be	VBP
cord-310268-8q4tk6fd	134	12	in	in	IN
cord-310268-8q4tk6fd	134	13	clinical	clinical	JJ
cord-310268-8q4tk6fd	134	14	use	use	NN
cord-310268-8q4tk6fd	134	15	at	at	IN
cord-310268-8q4tk6fd	134	16	the	the	DT
cord-310268-8q4tk6fd	134	17	moment	moment	NN
cord-310268-8q4tk6fd	134	18	,	,	,
cord-310268-8q4tk6fd	134	19	many	many	JJ
cord-310268-8q4tk6fd	134	20	preclinical	preclinical	JJ
cord-310268-8q4tk6fd	134	21	studies	study	NNS
cord-310268-8q4tk6fd	134	22	indicate	indicate	VBP
cord-310268-8q4tk6fd	134	23	that	that	IN
cord-310268-8q4tk6fd	134	24	DNA	DNA	NNP
cord-310268-8q4tk6fd	134	25	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	134	26	have	have	VBP
cord-310268-8q4tk6fd	134	27	great	great	JJ
cord-310268-8q4tk6fd	134	28	potential	potential	NN
cord-310268-8q4tk6fd	134	29	to	to	TO
cord-310268-8q4tk6fd	134	30	be	be	VB
cord-310268-8q4tk6fd	134	31	used	use	VBN
cord-310268-8q4tk6fd	134	32	in	in	IN
cord-310268-8q4tk6fd	134	33	this	this	DT
cord-310268-8q4tk6fd	134	34	way	way	NN
cord-310268-8q4tk6fd	134	35	.	.	.
cord-310268-8q4tk6fd	135	1	To	to	TO
cord-310268-8q4tk6fd	135	2	profile	profile	VB
cord-310268-8q4tk6fd	135	3	the	the	DT
cord-310268-8q4tk6fd	135	4	features	feature	NNS
cord-310268-8q4tk6fd	135	5	of	of	IN
cord-310268-8q4tk6fd	135	6	recent	recent	JJ
cord-310268-8q4tk6fd	135	7	studies	study	NNS
cord-310268-8q4tk6fd	135	8	that	that	WDT
cord-310268-8q4tk6fd	135	9	use	use	VBP
cord-310268-8q4tk6fd	135	10	DNA	DNA	NNP
cord-310268-8q4tk6fd	135	11	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	135	12	as	as	IN
cord-310268-8q4tk6fd	135	13	a	a	DT
cord-310268-8q4tk6fd	135	14	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	135	15	tool	tool	NN
cord-310268-8q4tk6fd	135	16	for	for	IN
cord-310268-8q4tk6fd	135	17	human	human	JJ
cord-310268-8q4tk6fd	135	18	diseases	disease	NNS
cord-310268-8q4tk6fd	135	19	,	,	,
cord-310268-8q4tk6fd	135	20	we	-PRON-	PRP
cord-310268-8q4tk6fd	135	21	listed	list	VBD
cord-310268-8q4tk6fd	135	22	some	some	DT
cord-310268-8q4tk6fd	135	23	DNA	DNA	NNP
cord-310268-8q4tk6fd	135	24	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	135	25	selected	select	VBN
cord-310268-8q4tk6fd	135	26	for	for	IN
cord-310268-8q4tk6fd	135	27	this	this	DT
cord-310268-8q4tk6fd	135	28	purpose	purpose	NN
cord-310268-8q4tk6fd	135	29	in	in	IN
cord-310268-8q4tk6fd	135	30	Table	Table	NNP
cord-310268-8q4tk6fd	135	31	1	1	CD
cord-310268-8q4tk6fd	135	32	,	,	,
cord-310268-8q4tk6fd	135	33	with	with	IN
cord-310268-8q4tk6fd	135	34	a	a	DT
cord-310268-8q4tk6fd	135	35	special	special	JJ
cord-310268-8q4tk6fd	135	36	attention	attention	NN
cord-310268-8q4tk6fd	135	37	to	to	IN
cord-310268-8q4tk6fd	135	38	parameters	parameter	NNS
cord-310268-8q4tk6fd	135	39	like	like	IN
cord-310268-8q4tk6fd	135	40	the	the	DT
cord-310268-8q4tk6fd	135	41	sensitivity	sensitivity	NN
cord-310268-8q4tk6fd	135	42	and	and	CC
cord-310268-8q4tk6fd	135	43	specificity	specificity	NN
cord-310268-8q4tk6fd	135	44	,	,	,
cord-310268-8q4tk6fd	135	45	which	which	WDT
cord-310268-8q4tk6fd	135	46	have	have	VBP
cord-310268-8q4tk6fd	135	47	a	a	DT
cord-310268-8q4tk6fd	135	48	great	great	JJ
cord-310268-8q4tk6fd	135	49	impact	impact	NN
cord-310268-8q4tk6fd	135	50	on	on	IN
cord-310268-8q4tk6fd	135	51	their	-PRON-	PRP$
cord-310268-8q4tk6fd	135	52	potential	potential	NN
cord-310268-8q4tk6fd	135	53	for	for	IN
cord-310268-8q4tk6fd	135	54	clinical	clinical	JJ
cord-310268-8q4tk6fd	135	55	use	use	NN
cord-310268-8q4tk6fd	135	56	.	.	.
cord-310268-8q4tk6fd	136	1	In	in	IN
cord-310268-8q4tk6fd	136	2	theory	theory	NN
cord-310268-8q4tk6fd	136	3	,	,	,
cord-310268-8q4tk6fd	136	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	136	5	can	can	MD
cord-310268-8q4tk6fd	136	6	be	be	VB
cord-310268-8q4tk6fd	136	7	selected	select	VBN
cord-310268-8q4tk6fd	136	8	for	for	IN
cord-310268-8q4tk6fd	136	9	developing	develop	VBG
cord-310268-8q4tk6fd	136	10	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	136	11	tools	tool	NNS
cord-310268-8q4tk6fd	136	12	for	for	IN
cord-310268-8q4tk6fd	136	13	various	various	JJ
cord-310268-8q4tk6fd	136	14	diseases	disease	NNS
cord-310268-8q4tk6fd	136	15	,	,	,
cord-310268-8q4tk6fd	136	16	as	as	RB
cord-310268-8q4tk6fd	136	17	long	long	RB
cord-310268-8q4tk6fd	136	18	as	as	IN
cord-310268-8q4tk6fd	136	19	definite	definite	JJ
cord-310268-8q4tk6fd	136	20	targets	target	NNS
cord-310268-8q4tk6fd	136	21	,	,	,
cord-310268-8q4tk6fd	136	22	such	such	JJ
cord-310268-8q4tk6fd	136	23	as	as	IN
cord-310268-8q4tk6fd	136	24	disease	disease	NN
cord-310268-8q4tk6fd	136	25	-	-	HYPH
cord-310268-8q4tk6fd	136	26	specific	specific	JJ
cord-310268-8q4tk6fd	136	27	biomarkers	biomarker	NNS
cord-310268-8q4tk6fd	136	28	or	or	CC
cord-310268-8q4tk6fd	136	29	pathogens	pathogen	NNS
cord-310268-8q4tk6fd	136	30	,	,	,
cord-310268-8q4tk6fd	136	31	are	be	VBP
cord-310268-8q4tk6fd	136	32	available	available	JJ
cord-310268-8q4tk6fd	136	33	.	.	.
cord-310268-8q4tk6fd	137	1	To	to	IN
cord-310268-8q4tk6fd	137	2	date	date	NN
cord-310268-8q4tk6fd	137	3	,	,	,
cord-310268-8q4tk6fd	137	4	DNA	dna	NN
cord-310268-8q4tk6fd	137	5	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	137	6	have	have	VBP
cord-310268-8q4tk6fd	137	7	been	be	VBN
cord-310268-8q4tk6fd	137	8	explored	explore	VBN
cord-310268-8q4tk6fd	137	9	mainly	mainly	RB
cord-310268-8q4tk6fd	137	10	for	for	IN
cord-310268-8q4tk6fd	137	11	the	the	DT
cord-310268-8q4tk6fd	137	12	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	137	13	of	of	IN
cord-310268-8q4tk6fd	137	14	infectious	infectious	JJ
cord-310268-8q4tk6fd	137	15	diseases	disease	NNS
cord-310268-8q4tk6fd	137	16	,	,	,
cord-310268-8q4tk6fd	137	17	cancer	cancer	NN
cord-310268-8q4tk6fd	137	18	and	and	CC
cord-310268-8q4tk6fd	137	19	cardiovascular	cardiovascular	JJ
cord-310268-8q4tk6fd	137	20	diseases	disease	NNS
cord-310268-8q4tk6fd	137	21	.	.	.
cord-310268-8q4tk6fd	138	1	Because	because	IN
cord-310268-8q4tk6fd	138	2	of	of	IN
cord-310268-8q4tk6fd	138	3	the	the	DT
cord-310268-8q4tk6fd	138	4	convenience	convenience	NN
cord-310268-8q4tk6fd	138	5	of	of	IN
cord-310268-8q4tk6fd	138	6	cell	cell	NN
cord-310268-8q4tk6fd	138	7	-	-	HYPH
cord-310268-8q4tk6fd	138	8	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	138	9	,	,	,
cord-310268-8q4tk6fd	138	10	which	which	WDT
cord-310268-8q4tk6fd	138	11	does	do	VBZ
cord-310268-8q4tk6fd	138	12	not	not	RB
cord-310268-8q4tk6fd	138	13	require	require	VB
cord-310268-8q4tk6fd	138	14	preparation	preparation	NN
cord-310268-8q4tk6fd	138	15	and	and	CC
cord-310268-8q4tk6fd	138	16	purification	purification	NN
cord-310268-8q4tk6fd	138	17	of	of	IN
cord-310268-8q4tk6fd	138	18	target	target	NN
cord-310268-8q4tk6fd	138	19	molecules	molecule	NNS
cord-310268-8q4tk6fd	138	20	,	,	,
cord-310268-8q4tk6fd	138	21	many	many	JJ
cord-310268-8q4tk6fd	138	22	reported	report	VBN
cord-310268-8q4tk6fd	138	23	DNA	DNA	NNP
cord-310268-8q4tk6fd	138	24	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	138	25	are	be	VBP
cord-310268-8q4tk6fd	138	26	selected	select	VBN
cord-310268-8q4tk6fd	138	27	with	with	IN
cord-310268-8q4tk6fd	138	28	cancer	cancer	NN
cord-310268-8q4tk6fd	138	29	cells	cell	NNS
cord-310268-8q4tk6fd	138	30	,	,	,
cord-310268-8q4tk6fd	138	31	aiming	aim	VBG
cord-310268-8q4tk6fd	138	32	to	to	TO
cord-310268-8q4tk6fd	138	33	diagnose	diagnose	VB
cord-310268-8q4tk6fd	138	34	and	and	CC
cord-310268-8q4tk6fd	138	35	image	image	VB
cord-310268-8q4tk6fd	138	36	cancer	cancer	NN
cord-310268-8q4tk6fd	138	37	tissue	tissue	NN
cord-310268-8q4tk6fd	138	38	.	.	.
cord-310268-8q4tk6fd	139	1	These	these	DT
cord-310268-8q4tk6fd	139	2	cancer	cancer	NN
cord-310268-8q4tk6fd	139	3	cells	cell	NNS
cord-310268-8q4tk6fd	139	4	include	include	VBP
cord-310268-8q4tk6fd	139	5	pancreatic	pancreatic	JJ
cord-310268-8q4tk6fd	139	6	[	[	-LRB-
cord-310268-8q4tk6fd	139	7	54	54	CD
cord-310268-8q4tk6fd	139	8	]	]	-RRB-
cord-310268-8q4tk6fd	139	9	,	,	,
cord-310268-8q4tk6fd	139	10	colon	colon	NN
cord-310268-8q4tk6fd	139	11	[	[	-LRB-
cord-310268-8q4tk6fd	139	12	30	30	CD
cord-310268-8q4tk6fd	139	13	]	]	-RRB-
cord-310268-8q4tk6fd	139	14	,	,	,
cord-310268-8q4tk6fd	139	15	liver	liver	NN
cord-310268-8q4tk6fd	139	16	[	[	-LRB-
cord-310268-8q4tk6fd	139	17	55	55	CD
cord-310268-8q4tk6fd	139	18	,	,	,
cord-310268-8q4tk6fd	139	19	56	56	CD
cord-310268-8q4tk6fd	139	20	]	]	-RRB-
cord-310268-8q4tk6fd	139	21	,	,	,
cord-310268-8q4tk6fd	139	22	cholangio	cholangio	VBN
cord-310268-8q4tk6fd	139	23	[	[	-LRB-
cord-310268-8q4tk6fd	139	24	57	57	CD
cord-310268-8q4tk6fd	139	25	]	]	-RRB-
cord-310268-8q4tk6fd	139	26	,	,	,
cord-310268-8q4tk6fd	139	27	gastric	gastric	JJ
cord-310268-8q4tk6fd	139	28	[	[	-LRB-
cord-310268-8q4tk6fd	139	29	58	58	CD
cord-310268-8q4tk6fd	139	30	,	,	,
cord-310268-8q4tk6fd	139	31	59	59	CD
cord-310268-8q4tk6fd	139	32	]	]	-RRB-
cord-310268-8q4tk6fd	139	33	,	,	,
cord-310268-8q4tk6fd	139	34	prostate	prostate	NN
cord-310268-8q4tk6fd	139	35	[	[	-LRB-
cord-310268-8q4tk6fd	139	36	27	27	CD
cord-310268-8q4tk6fd	139	37	]	]	-RRB-
cord-310268-8q4tk6fd	139	38	,	,	,
cord-310268-8q4tk6fd	139	39	breast	breast	NN
cord-310268-8q4tk6fd	139	40	[	[	-LRB-
cord-310268-8q4tk6fd	139	41	60	60	CD
cord-310268-8q4tk6fd	139	42	]	]	-RRB-
cord-310268-8q4tk6fd	139	43	and	and	CC
cord-310268-8q4tk6fd	139	44	glioblastoma	glioblastoma	NN
cord-310268-8q4tk6fd	139	45	[	[	-LRB-
cord-310268-8q4tk6fd	139	46	61	61	CD
cord-310268-8q4tk6fd	139	47	]	]	-RRB-
cord-310268-8q4tk6fd	139	48	cancer	cancer	NN
cord-310268-8q4tk6fd	139	49	cells	cell	NNS
cord-310268-8q4tk6fd	139	50	.	.	.
cord-310268-8q4tk6fd	140	1	Usually	usually	RB
cord-310268-8q4tk6fd	140	2	,	,	,
cord-310268-8q4tk6fd	140	3	the	the	DT
cord-310268-8q4tk6fd	140	4	selection	selection	NN
cord-310268-8q4tk6fd	140	5	consists	consist	VBZ
cord-310268-8q4tk6fd	140	6	of	of	IN
cord-310268-8q4tk6fd	140	7	positive	positive	JJ
cord-310268-8q4tk6fd	140	8	selection	selection	NN
cord-310268-8q4tk6fd	140	9	with	with	IN
cord-310268-8q4tk6fd	140	10	cancer	cancer	NN
cord-310268-8q4tk6fd	140	11	cells	cell	NNS
cord-310268-8q4tk6fd	140	12	and	and	CC
cord-310268-8q4tk6fd	140	13	negative	negative	JJ
cord-310268-8q4tk6fd	140	14	selection	selection	NN
cord-310268-8q4tk6fd	140	15	with	with	IN
cord-310268-8q4tk6fd	140	16	normal	normal	JJ
cord-310268-8q4tk6fd	140	17	cells	cell	NNS
cord-310268-8q4tk6fd	140	18	from	from	IN
cord-310268-8q4tk6fd	140	19	the	the	DT
cord-310268-8q4tk6fd	140	20	same	same	JJ
cord-310268-8q4tk6fd	140	21	organs	organ	NNS
cord-310268-8q4tk6fd	140	22	,	,	,
cord-310268-8q4tk6fd	140	23	as	as	IN
cord-310268-8q4tk6fd	140	24	described	describe	VBN
cord-310268-8q4tk6fd	140	25	in	in	IN
cord-310268-8q4tk6fd	140	26	Section	section	NN
cord-310268-8q4tk6fd	140	27	2.2.3	2.2.3	CD
cord-310268-8q4tk6fd	140	28	.	.	.
cord-310268-8q4tk6fd	141	1	It	-PRON-	PRP
cord-310268-8q4tk6fd	141	2	is	be	VBZ
cord-310268-8q4tk6fd	141	3	worth	worth	JJ
cord-310268-8q4tk6fd	141	4	noting	note	VBG
cord-310268-8q4tk6fd	141	5	that	that	IN
cord-310268-8q4tk6fd	141	6	,	,	,
cord-310268-8q4tk6fd	141	7	because	because	IN
cord-310268-8q4tk6fd	141	8	the	the	DT
cord-310268-8q4tk6fd	141	9	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	141	10	and	and	CC
cord-310268-8q4tk6fd	141	11	monitoring	monitoring	NN
cord-310268-8q4tk6fd	141	12	of	of	IN
cord-310268-8q4tk6fd	141	13	metastasis	metastasis	NN
cord-310268-8q4tk6fd	141	14	of	of	IN
cord-310268-8q4tk6fd	141	15	cancer	cancer	NN
cord-310268-8q4tk6fd	141	16	cells	cell	NNS
cord-310268-8q4tk6fd	141	17	is	be	VBZ
cord-310268-8q4tk6fd	141	18	important	important	JJ
cord-310268-8q4tk6fd	141	19	for	for	IN
cord-310268-8q4tk6fd	141	20	the	the	DT
cord-310268-8q4tk6fd	141	21	treatment	treatment	NN
cord-310268-8q4tk6fd	141	22	of	of	IN
cord-310268-8q4tk6fd	141	23	cancer	cancer	NN
cord-310268-8q4tk6fd	141	24	,	,	,
cord-310268-8q4tk6fd	141	25	several	several	JJ
cord-310268-8q4tk6fd	141	26	DNA	dna	NN
cord-310268-8q4tk6fd	141	27	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	141	28	have	have	VBP
cord-310268-8q4tk6fd	141	29	been	be	VBN
cord-310268-8q4tk6fd	141	30	selected	select	VBN
cord-310268-8q4tk6fd	141	31	with	with	IN
cord-310268-8q4tk6fd	141	32	metastatic	metastatic	JJ
cord-310268-8q4tk6fd	141	33	cancer	cancer	NN
cord-310268-8q4tk6fd	141	34	cells	cell	NNS
cord-310268-8q4tk6fd	141	35	and	and	CC
cord-310268-8q4tk6fd	141	36	negatively	negatively	RB
cord-310268-8q4tk6fd	141	37	selected	select	VBN
cord-310268-8q4tk6fd	141	38	with	with	IN
cord-310268-8q4tk6fd	141	39	non	non	JJ
cord-310268-8q4tk6fd	141	40	-	-	JJ
cord-310268-8q4tk6fd	141	41	metastatic	metastatic	JJ
cord-310268-8q4tk6fd	141	42	cancer	cancer	NN
cord-310268-8q4tk6fd	141	43	cells	cell	NNS
cord-310268-8q4tk6fd	141	44	[	[	-LRB-
cord-310268-8q4tk6fd	141	45	27	27	CD
cord-310268-8q4tk6fd	141	46	,	,	,
cord-310268-8q4tk6fd	141	47	30	30	CD
cord-310268-8q4tk6fd	141	48	,	,	,
cord-310268-8q4tk6fd	141	49	60	60	CD
cord-310268-8q4tk6fd	141	50	]	]	-RRB-
cord-310268-8q4tk6fd	141	51	.	.	.
cord-310268-8q4tk6fd	142	1	Target	target	NN
cord-310268-8q4tk6fd	142	2	-	-	HYPH
cord-310268-8q4tk6fd	142	3	induced	induce	VBN
cord-310268-8q4tk6fd	142	4	dissociation	dissociation	NN
cord-310268-8q4tk6fd	142	5	(	(	-LRB-
cord-310268-8q4tk6fd	142	6	AuNP	aunp	NN
cord-310268-8q4tk6fd	142	7	)	)	-RRB-
cord-310268-8q4tk6fd	142	8	0.5	0.5	CD
cord-310268-8q4tk6fd	142	9	µM	µm	CD
cord-310268-8q4tk6fd	142	10	100	100	CD
cord-310268-8q4tk6fd	142	11	%	%	NN
cord-310268-8q4tk6fd	142	12	(	(	-LRB-
cord-310268-8q4tk6fd	142	13	n	n	NN
cord-310268-8q4tk6fd	142	14	=	=	SYM
cord-310268-8q4tk6fd	142	15	3	3	CD
cord-310268-8q4tk6fd	142	16	amino	amino	JJ
cord-310268-8q4tk6fd	142	17	acids	acid	NNS
cord-310268-8q4tk6fd	142	18	)	)	-RRB-
cord-310268-8q4tk6fd	142	19	[	[	-LRB-
cord-310268-8q4tk6fd	142	20	73	73	CD
cord-310268-8q4tk6fd	142	21	]	]	-RRB-
cord-310268-8q4tk6fd	143	1	ns	ns	UH
cord-310268-8q4tk6fd	143	2	.	.	.
cord-310268-8q4tk6fd	143	3	:	:	:
cord-310268-8q4tk6fd	143	4	non	non	JJ
cord-310268-8q4tk6fd	143	5	-	-	JJ
cord-310268-8q4tk6fd	143	6	specified	specified	JJ
cord-310268-8q4tk6fd	143	7	.	.	.
cord-310268-8q4tk6fd	144	1	For	for	IN
cord-310268-8q4tk6fd	144	2	example	example	NN
cord-310268-8q4tk6fd	144	3	,	,	,
cord-310268-8q4tk6fd	144	4	Li	Li	NNP
cord-310268-8q4tk6fd	144	5	et	et	NNP
cord-310268-8q4tk6fd	144	6	al	al	NNP
cord-310268-8q4tk6fd	144	7	.	.	.
cord-310268-8q4tk6fd	145	1	selected	select	VBN
cord-310268-8q4tk6fd	145	2	DNA	DNA	NNP
cord-310268-8q4tk6fd	145	3	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	145	4	for	for	IN
cord-310268-8q4tk6fd	145	5	metastatic	metastatic	JJ
cord-310268-8q4tk6fd	145	6	colon	colon	NN
cord-310268-8q4tk6fd	145	7	cancer	cancer	NN
cord-310268-8q4tk6fd	145	8	cells	cell	NNS
cord-310268-8q4tk6fd	145	9	using	use	VBG
cord-310268-8q4tk6fd	145	10	SW620	SW620	NNP
cord-310268-8q4tk6fd	145	11	cells	cell	NNS
cord-310268-8q4tk6fd	145	12	derived	derive	VBN
cord-310268-8q4tk6fd	145	13	from	from	IN
cord-310268-8q4tk6fd	145	14	a	a	DT
cord-310268-8q4tk6fd	145	15	metastatic	metastatic	JJ
cord-310268-8q4tk6fd	145	16	site	site	NN
cord-310268-8q4tk6fd	145	17	lymph	lymph	NN
cord-310268-8q4tk6fd	145	18	node	node	NN
cord-310268-8q4tk6fd	145	19	in	in	IN
cord-310268-8q4tk6fd	145	20	the	the	DT
cord-310268-8q4tk6fd	145	21	positive	positive	JJ
cord-310268-8q4tk6fd	145	22	selection	selection	NN
cord-310268-8q4tk6fd	145	23	and	and	CC
cord-310268-8q4tk6fd	145	24	SW480	SW480	NNP
cord-310268-8q4tk6fd	145	25	cells	cell	NNS
cord-310268-8q4tk6fd	145	26	from	from	IN
cord-310268-8q4tk6fd	145	27	a	a	DT
cord-310268-8q4tk6fd	145	28	primary	primary	JJ
cord-310268-8q4tk6fd	145	29	colon	colon	NN
cord-310268-8q4tk6fd	145	30	adenocarcinoma	adenocarcinoma	NN
cord-310268-8q4tk6fd	145	31	of	of	IN
cord-310268-8q4tk6fd	145	32	the	the	DT
cord-310268-8q4tk6fd	145	33	same	same	JJ
cord-310268-8q4tk6fd	145	34	patient	patient	NN
cord-310268-8q4tk6fd	145	35	in	in	IN
cord-310268-8q4tk6fd	145	36	the	the	DT
cord-310268-8q4tk6fd	145	37	negative	negative	JJ
cord-310268-8q4tk6fd	145	38	selection	selection	NN
cord-310268-8q4tk6fd	145	39	[	[	-LRB-
cord-310268-8q4tk6fd	145	40	30	30	CD
cord-310268-8q4tk6fd	145	41	]	]	-RRB-
cord-310268-8q4tk6fd	145	42	.	.	.
cord-310268-8q4tk6fd	146	1	The	the	DT
cord-310268-8q4tk6fd	146	2	resulting	result	VBG
cord-310268-8q4tk6fd	146	3	aptamer	aptamer	NN
cord-310268-8q4tk6fd	146	4	(	(	-LRB-
cord-310268-8q4tk6fd	146	5	XL-33	XL-33	NNP
cord-310268-8q4tk6fd	146	6	)	)	-RRB-
cord-310268-8q4tk6fd	146	7	was	be	VBD
cord-310268-8q4tk6fd	146	8	found	find	VBN
cord-310268-8q4tk6fd	146	9	to	to	TO
cord-310268-8q4tk6fd	146	10	possess	possess	VB
cord-310268-8q4tk6fd	146	11	specific	specific	JJ
cord-310268-8q4tk6fd	146	12	affinity	affinity	NN
cord-310268-8q4tk6fd	146	13	to	to	IN
cord-310268-8q4tk6fd	146	14	the	the	DT
cord-310268-8q4tk6fd	146	15	metastatic	metastatic	JJ
cord-310268-8q4tk6fd	146	16	colon	colon	NN
cord-310268-8q4tk6fd	146	17	cancer	cancer	NN
cord-310268-8q4tk6fd	146	18	cells	cell	NNS
cord-310268-8q4tk6fd	146	19	(	(	-LRB-
cord-310268-8q4tk6fd	146	20	K	k	NN
cord-310268-8q4tk6fd	146	21	d	d	NN
cord-310268-8q4tk6fd	146	22	=	=	SYM
cord-310268-8q4tk6fd	146	23	0.7	0.7	CD
cord-310268-8q4tk6fd	146	24	nM	nm	NN
cord-310268-8q4tk6fd	146	25	)	)	-RRB-
cord-310268-8q4tk6fd	146	26	.	.	.
cord-310268-8q4tk6fd	147	1	Its	-PRON-	PRP$
cord-310268-8q4tk6fd	147	2	truncated	truncated	JJ
cord-310268-8q4tk6fd	147	3	form	form	NN
cord-310268-8q4tk6fd	147	4	(	(	-LRB-
cord-310268-8q4tk6fd	147	5	XL-33	XL-33	NNP
cord-310268-8q4tk6fd	147	6	-	-	HYPH
cord-310268-8q4tk6fd	147	7	1	1	CD
cord-310268-8q4tk6fd	147	8	)	)	-RRB-
cord-310268-8q4tk6fd	147	9	was	be	VBD
cord-310268-8q4tk6fd	147	10	used	use	VBN
cord-310268-8q4tk6fd	147	11	to	to	TO
cord-310268-8q4tk6fd	147	12	image	image	VB
cord-310268-8q4tk6fd	147	13	the	the	DT
cord-310268-8q4tk6fd	147	14	cancer	cancer	NN
cord-310268-8q4tk6fd	147	15	tissue	tissue	NN
cord-310268-8q4tk6fd	147	16	after	after	IN
cord-310268-8q4tk6fd	147	17	labeling	label	VBG
cord-310268-8q4tk6fd	147	18	with	with	IN
cord-310268-8q4tk6fd	147	19	fluorescein	fluorescein	NN
cord-310268-8q4tk6fd	147	20	amidite	amidite	JJ
cord-310268-8q4tk6fd	147	21	(	(	-LRB-
cord-310268-8q4tk6fd	147	22	FAM	FAM	NNP
cord-310268-8q4tk6fd	147	23	)	)	-RRB-
cord-310268-8q4tk6fd	147	24	,	,	,
cord-310268-8q4tk6fd	147	25	displaying	display	VBG
cord-310268-8q4tk6fd	147	26	an	an	DT
cord-310268-8q4tk6fd	147	27	81.7	81.7	CD
cord-310268-8q4tk6fd	147	28	%	%	NN
cord-310268-8q4tk6fd	147	29	detection	detection	NN
cord-310268-8q4tk6fd	147	30	rate	rate	NN
cord-310268-8q4tk6fd	147	31	against	against	IN
cord-310268-8q4tk6fd	147	32	colon	colon	NN
cord-310268-8q4tk6fd	147	33	cancer	cancer	NN
cord-310268-8q4tk6fd	147	34	tissue	tissue	NN
cord-310268-8q4tk6fd	147	35	with	with	IN
cord-310268-8q4tk6fd	147	36	metastasis	metastasis	NN
cord-310268-8q4tk6fd	147	37	in	in	IN
cord-310268-8q4tk6fd	147	38	regional	regional	JJ
cord-310268-8q4tk6fd	147	39	lymph	lymph	NN
cord-310268-8q4tk6fd	147	40	nodes	node	NNS
cord-310268-8q4tk6fd	147	41	and	and	CC
cord-310268-8q4tk6fd	147	42	66.7	66.7	CD
cord-310268-8q4tk6fd	147	43	%	%	NN
cord-310268-8q4tk6fd	147	44	specificity	specificity	NN
cord-310268-8q4tk6fd	147	45	against	against	IN
cord-310268-8q4tk6fd	147	46	nonmetastatic	nonmetastatic	JJ
cord-310268-8q4tk6fd	147	47	colon	colon	NN
cord-310268-8q4tk6fd	147	48	cancer	cancer	NN
cord-310268-8q4tk6fd	147	49	tissue	tissue	NN
cord-310268-8q4tk6fd	147	50	.	.	.
cord-310268-8q4tk6fd	148	1	The	the	DT
cord-310268-8q4tk6fd	148	2	biomarker	biomarker	NN
cord-310268-8q4tk6fd	148	3	molecules	molecule	NNS
cord-310268-8q4tk6fd	148	4	that	that	WDT
cord-310268-8q4tk6fd	148	5	specifically	specifically	RB
cord-310268-8q4tk6fd	148	6	express	express	VBP
cord-310268-8q4tk6fd	148	7	or	or	CC
cord-310268-8q4tk6fd	148	8	overexpress	overexpres	VBN
cord-310268-8q4tk6fd	148	9	on	on	IN
cord-310268-8q4tk6fd	148	10	the	the	DT
cord-310268-8q4tk6fd	148	11	cancer	cancer	NN
cord-310268-8q4tk6fd	148	12	cells	cell	NNS
cord-310268-8q4tk6fd	148	13	were	be	VBD
cord-310268-8q4tk6fd	148	14	also	also	RB
cord-310268-8q4tk6fd	148	15	used	use	VBN
cord-310268-8q4tk6fd	148	16	for	for	IN
cord-310268-8q4tk6fd	148	17	the	the	DT
cord-310268-8q4tk6fd	148	18	selection	selection	NN
cord-310268-8q4tk6fd	148	19	of	of	IN
cord-310268-8q4tk6fd	148	20	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	148	21	DNA	dna	NN
cord-310268-8q4tk6fd	148	22	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	148	23	.	.	.
cord-310268-8q4tk6fd	149	1	In	in	IN
cord-310268-8q4tk6fd	149	2	addition	addition	NN
cord-310268-8q4tk6fd	149	3	to	to	IN
cord-310268-8q4tk6fd	149	4	the	the	DT
cord-310268-8q4tk6fd	149	5	previously	previously	RB
cord-310268-8q4tk6fd	149	6	known	know	VBN
cord-310268-8q4tk6fd	149	7	prostate	prostate	NN
cord-310268-8q4tk6fd	149	8	-	-	HYPH
cord-310268-8q4tk6fd	149	9	specific	specific	JJ
cord-310268-8q4tk6fd	149	10	membrane	membrane	NN
cord-310268-8q4tk6fd	149	11	antigen	antigen	NN
cord-310268-8q4tk6fd	149	12	(	(	-LRB-
cord-310268-8q4tk6fd	149	13	PSMA	PSMA	NNP
cord-310268-8q4tk6fd	149	14	)	)	-RRB-
cord-310268-8q4tk6fd	149	15	[	[	-LRB-
cord-310268-8q4tk6fd	149	16	74	74	CD
cord-310268-8q4tk6fd	149	17	]	]	-RRB-
cord-310268-8q4tk6fd	149	18	and	and	CC
cord-310268-8q4tk6fd	149	19	mucin	mucin	NN
cord-310268-8q4tk6fd	149	20	1	1	CD
cord-310268-8q4tk6fd	149	21	(	(	-LRB-
cord-310268-8q4tk6fd	149	22	MUC1	MUC1	NNP
cord-310268-8q4tk6fd	149	23	)	)	-RRB-
cord-310268-8q4tk6fd	149	24	[	[	-LRB-
cord-310268-8q4tk6fd	149	25	75	75	CD
cord-310268-8q4tk6fd	149	26	]	]	-RRB-
cord-310268-8q4tk6fd	149	27	,	,	,
cord-310268-8q4tk6fd	149	28	other	other	JJ
cord-310268-8q4tk6fd	149	29	biomarkers	biomarker	NNS
cord-310268-8q4tk6fd	149	30	like	like	IN
cord-310268-8q4tk6fd	149	31	epidermal	epidermal	JJ
cord-310268-8q4tk6fd	149	32	growth	growth	NN
cord-310268-8q4tk6fd	149	33	factor	factor	NN
cord-310268-8q4tk6fd	149	34	receptor	receptor	NN
cord-310268-8q4tk6fd	149	35	variant	variant	NN
cord-310268-8q4tk6fd	149	36	III	III	NNP
cord-310268-8q4tk6fd	149	37	(	(	-LRB-
cord-310268-8q4tk6fd	149	38	EGFRvIII	EGFRvIII	NNS
cord-310268-8q4tk6fd	149	39	)	)	-RRB-
cord-310268-8q4tk6fd	149	40	[	[	-LRB-
cord-310268-8q4tk6fd	149	41	62	62	CD
cord-310268-8q4tk6fd	149	42	]	]	-RRB-
cord-310268-8q4tk6fd	149	43	,	,	,
cord-310268-8q4tk6fd	149	44	epithelial	epithelial	JJ
cord-310268-8q4tk6fd	149	45	cell	cell	NN
cord-310268-8q4tk6fd	149	46	adhesion	adhesion	NN
cord-310268-8q4tk6fd	149	47	molecule	molecule	NN
cord-310268-8q4tk6fd	149	48	(	(	-LRB-
cord-310268-8q4tk6fd	149	49	EpCAM	EpCAM	NNP
cord-310268-8q4tk6fd	149	50	)	)	-RRB-
cord-310268-8q4tk6fd	150	1	[	[	-LRB-
cord-310268-8q4tk6fd	150	2	63	63	CD
cord-310268-8q4tk6fd	150	3	]	]	-RRB-
cord-310268-8q4tk6fd	150	4	and	and	CC
cord-310268-8q4tk6fd	150	5	vascular	vascular	JJ
cord-310268-8q4tk6fd	150	6	endothelial	endothelial	JJ
cord-310268-8q4tk6fd	150	7	growth	growth	NN
cord-310268-8q4tk6fd	150	8	factor	factor	NN
cord-310268-8q4tk6fd	151	1	(	(	-LRB-
cord-310268-8q4tk6fd	151	2	VEGF165	vegf165	NN
cord-310268-8q4tk6fd	151	3	)	)	-RRB-
cord-310268-8q4tk6fd	151	4	[	[	-LRB-
cord-310268-8q4tk6fd	151	5	64	64	CD
cord-310268-8q4tk6fd	151	6	]	]	-RRB-
cord-310268-8q4tk6fd	151	7	have	have	VBP
cord-310268-8q4tk6fd	151	8	also	also	RB
cord-310268-8q4tk6fd	151	9	been	be	VBN
cord-310268-8q4tk6fd	151	10	used	use	VBN
cord-310268-8q4tk6fd	151	11	to	to	TO
cord-310268-8q4tk6fd	151	12	select	select	VB
cord-310268-8q4tk6fd	151	13	DNA	DNA	NNP
cord-310268-8q4tk6fd	151	14	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	151	15	for	for	IN
cord-310268-8q4tk6fd	151	16	cancer	cancer	NN
cord-310268-8q4tk6fd	151	17	detection	detection	NN
cord-310268-8q4tk6fd	151	18	.	.	.
cord-310268-8q4tk6fd	152	1	By	by	IN
cord-310268-8q4tk6fd	152	2	directly	directly	RB
cord-310268-8q4tk6fd	152	3	using	use	VBG
cord-310268-8q4tk6fd	152	4	cancer	cancer	NN
cord-310268-8q4tk6fd	152	5	biomarkers	biomarker	NNS
cord-310268-8q4tk6fd	152	6	to	to	TO
cord-310268-8q4tk6fd	152	7	select	select	VB
cord-310268-8q4tk6fd	152	8	cancer	cancer	NN
cord-310268-8q4tk6fd	152	9	-	-	HYPH
cord-310268-8q4tk6fd	152	10	cell	cell	NN
cord-310268-8q4tk6fd	152	11	-	-	HYPH
cord-310268-8q4tk6fd	152	12	recognized	recognize	VBN
cord-310268-8q4tk6fd	152	13	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	152	14	,	,	,
cord-310268-8q4tk6fd	152	15	you	-PRON-	PRP
cord-310268-8q4tk6fd	152	16	obtain	obtain	VBP
cord-310268-8q4tk6fd	152	17	highly	highly	RB
cord-310268-8q4tk6fd	152	18	specific	specific	JJ
cord-310268-8q4tk6fd	152	19	and	and	CC
cord-310268-8q4tk6fd	152	20	affinitive	affinitive	JJ
cord-310268-8q4tk6fd	152	21	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	152	22	,	,	,
cord-310268-8q4tk6fd	152	23	but	but	CC
cord-310268-8q4tk6fd	152	24	the	the	DT
cord-310268-8q4tk6fd	152	25	potential	potential	JJ
cord-310268-8q4tk6fd	152	26	risk	risk	NN
cord-310268-8q4tk6fd	152	27	is	be	VBZ
cord-310268-8q4tk6fd	152	28	that	that	IN
cord-310268-8q4tk6fd	152	29	the	the	DT
cord-310268-8q4tk6fd	152	30	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	152	31	might	may	MD
cord-310268-8q4tk6fd	152	32	not	not	RB
cord-310268-8q4tk6fd	152	33	recognize	recognize	VB
cord-310268-8q4tk6fd	152	34	the	the	DT
cord-310268-8q4tk6fd	152	35	natural	natural	JJ
cord-310268-8q4tk6fd	152	36	biomarkers	biomarker	NNS
cord-310268-8q4tk6fd	152	37	on	on	IN
cord-310268-8q4tk6fd	152	38	the	the	DT
cord-310268-8q4tk6fd	152	39	surface	surface	NN
cord-310268-8q4tk6fd	152	40	of	of	IN
cord-310268-8q4tk6fd	152	41	cancer	cancer	NN
cord-310268-8q4tk6fd	152	42	cells	cell	NNS
cord-310268-8q4tk6fd	152	43	because	because	IN
cord-310268-8q4tk6fd	152	44	of	of	IN
cord-310268-8q4tk6fd	152	45	the	the	DT
cord-310268-8q4tk6fd	152	46	difference	difference	NN
cord-310268-8q4tk6fd	152	47	in	in	IN
cord-310268-8q4tk6fd	152	48	the	the	DT
cord-310268-8q4tk6fd	152	49	3D	3d	JJ
cord-310268-8q4tk6fd	152	50	structure	structure	NN
cord-310268-8q4tk6fd	152	51	of	of	IN
cord-310268-8q4tk6fd	152	52	the	the	DT
cord-310268-8q4tk6fd	152	53	purified	purify	VBN
cord-310268-8q4tk6fd	152	54	biomarkers	biomarker	NNS
cord-310268-8q4tk6fd	152	55	and	and	CC
cord-310268-8q4tk6fd	152	56	the	the	DT
cord-310268-8q4tk6fd	152	57	natural	natural	JJ
cord-310268-8q4tk6fd	152	58	biomarkers	biomarker	NNS
cord-310268-8q4tk6fd	152	59	.	.	.
cord-310268-8q4tk6fd	153	1	For	for	IN
cord-310268-8q4tk6fd	153	2	the	the	DT
cord-310268-8q4tk6fd	153	3	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	153	4	of	of	IN
cord-310268-8q4tk6fd	153	5	infectious	infectious	JJ
cord-310268-8q4tk6fd	153	6	agents	agent	NNS
cord-310268-8q4tk6fd	153	7	,	,	,
cord-310268-8q4tk6fd	153	8	lots	lot	NNS
cord-310268-8q4tk6fd	153	9	of	of	IN
cord-310268-8q4tk6fd	153	10	DNA	dna	NN
cord-310268-8q4tk6fd	153	11	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	153	12	have	have	VBP
cord-310268-8q4tk6fd	153	13	been	be	VBN
cord-310268-8q4tk6fd	153	14	selected	select	VBN
cord-310268-8q4tk6fd	153	15	predominantly	predominantly	RB
cord-310268-8q4tk6fd	153	16	with	with	IN
cord-310268-8q4tk6fd	153	17	cell	cell	NN
cord-310268-8q4tk6fd	153	18	-	-	HYPH
cord-310268-8q4tk6fd	153	19	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	153	20	and	and	CC
cord-310268-8q4tk6fd	153	21	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	153	22	beads	bead	NNS
cord-310268-8q4tk6fd	153	23	-	-	HYPH
cord-310268-8q4tk6fd	153	24	based	base	VBN
cord-310268-8q4tk6fd	153	25	methods	method	NNS
cord-310268-8q4tk6fd	153	26	by	by	IN
cord-310268-8q4tk6fd	153	27	targeting	target	VBG
cord-310268-8q4tk6fd	153	28	various	various	JJ
cord-310268-8q4tk6fd	153	29	viruses	virus	NNS
cord-310268-8q4tk6fd	153	30	and	and	CC
cord-310268-8q4tk6fd	153	31	bacteria	bacteria	NNS
cord-310268-8q4tk6fd	153	32	or	or	CC
cord-310268-8q4tk6fd	153	33	their	-PRON-	PRP$
cord-310268-8q4tk6fd	153	34	antigen	antigen	NN
cord-310268-8q4tk6fd	153	35	protein	protein	NN
cord-310268-8q4tk6fd	153	36	[	[	-LRB-
cord-310268-8q4tk6fd	153	37	6	6	CD
cord-310268-8q4tk6fd	153	38	]	]	-RRB-
cord-310268-8q4tk6fd	153	39	,	,	,
cord-310268-8q4tk6fd	153	40	including	include	VBG
cord-310268-8q4tk6fd	153	41	targets	target	NNS
cord-310268-8q4tk6fd	153	42	such	such	JJ
cord-310268-8q4tk6fd	153	43	as	as	IN
cord-310268-8q4tk6fd	153	44	norovirus	norovirus	NN
cord-310268-8q4tk6fd	153	45	,	,	,
cord-310268-8q4tk6fd	153	46	influenza	influenza	NN
cord-310268-8q4tk6fd	153	47	virus	virus	NN
cord-310268-8q4tk6fd	153	48	,	,	,
cord-310268-8q4tk6fd	153	49	severe	severe	JJ
cord-310268-8q4tk6fd	153	50	acute	acute	JJ
cord-310268-8q4tk6fd	153	51	respiratory	respiratory	JJ
cord-310268-8q4tk6fd	153	52	syndrome	syndrome	NN
cord-310268-8q4tk6fd	153	53	coronavirus	coronavirus	NN
cord-310268-8q4tk6fd	153	54	(	(	-LRB-
cord-310268-8q4tk6fd	153	55	SARS	SARS	NNP
cord-310268-8q4tk6fd	153	56	-	-	HYPH
cord-310268-8q4tk6fd	153	57	CoV	CoV	NNP
cord-310268-8q4tk6fd	153	58	)	)	-RRB-
cord-310268-8q4tk6fd	153	59	,	,	,
cord-310268-8q4tk6fd	153	60	hepatitis	hepatitis	NN
cord-310268-8q4tk6fd	153	61	C	C	NNP
cord-310268-8q4tk6fd	153	62	virus	virus	NN
cord-310268-8q4tk6fd	153	63	(	(	-LRB-
cord-310268-8q4tk6fd	153	64	HCV	HCV	NNP
cord-310268-8q4tk6fd	153	65	)	)	-RRB-
cord-310268-8q4tk6fd	153	66	,	,	,
cord-310268-8q4tk6fd	153	67	hepatitis	hepatitis	NN
cord-310268-8q4tk6fd	153	68	B	B	NNP
cord-310268-8q4tk6fd	153	69	virus	virus	NN
cord-310268-8q4tk6fd	153	70	(	(	-LRB-
cord-310268-8q4tk6fd	153	71	HBV	HBV	NNP
cord-310268-8q4tk6fd	153	72	)	)	-RRB-
cord-310268-8q4tk6fd	153	73	,	,	,
cord-310268-8q4tk6fd	153	74	human	human	JJ
cord-310268-8q4tk6fd	153	75	immunodeficiency	immunodeficiency	NN
cord-310268-8q4tk6fd	153	76	virus	virus	NN
cord-310268-8q4tk6fd	153	77	(	(	-LRB-
cord-310268-8q4tk6fd	153	78	HIV	HIV	NNP
cord-310268-8q4tk6fd	153	79	)	)	-RRB-
cord-310268-8q4tk6fd	153	80	,	,	,
cord-310268-8q4tk6fd	153	81	human	human	JJ
cord-310268-8q4tk6fd	153	82	papillomavirus	papillomavirus	NN
cord-310268-8q4tk6fd	153	83	(	(	-LRB-
cord-310268-8q4tk6fd	153	84	HPV	HPV	NNP
cord-310268-8q4tk6fd	153	85	)	)	-RRB-
cord-310268-8q4tk6fd	153	86	,	,	,
cord-310268-8q4tk6fd	153	87	salmonella	salmonella	NN
cord-310268-8q4tk6fd	153	88	typhimurium	typhimurium	NN
cord-310268-8q4tk6fd	153	89	,	,	,
cord-310268-8q4tk6fd	153	90	and	and	CC
cord-310268-8q4tk6fd	153	91	pathogenic	pathogenic	JJ
cord-310268-8q4tk6fd	153	92	E.	E.	NNP
cord-310268-8q4tk6fd	153	93	coli	coli	NNS
cord-310268-8q4tk6fd	153	94	.	.	.
cord-310268-8q4tk6fd	154	1	Because	because	IN
cord-310268-8q4tk6fd	154	2	of	of	IN
cord-310268-8q4tk6fd	154	3	the	the	DT
cord-310268-8q4tk6fd	154	4	low	low	JJ
cord-310268-8q4tk6fd	154	5	cost	cost	NN
cord-310268-8q4tk6fd	154	6	and	and	CC
cord-310268-8q4tk6fd	154	7	short	short	JJ
cord-310268-8q4tk6fd	154	8	production	production	NN
cord-310268-8q4tk6fd	154	9	time	time	NN
cord-310268-8q4tk6fd	154	10	of	of	IN
cord-310268-8q4tk6fd	154	11	DNA	DNA	NNP
cord-310268-8q4tk6fd	154	12	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	154	13	,	,	,
cord-310268-8q4tk6fd	154	14	the	the	DT
cord-310268-8q4tk6fd	154	15	DNA	DNA	NNP
cord-310268-8q4tk6fd	154	16	aptamer	aptamer	NN
cord-310268-8q4tk6fd	154	17	based	base	VBN
cord-310268-8q4tk6fd	154	18	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	154	19	tools	tool	NNS
cord-310268-8q4tk6fd	154	20	hold	hold	VBP
cord-310268-8q4tk6fd	154	21	particular	particular	JJ
cord-310268-8q4tk6fd	154	22	advantages	advantage	NNS
cord-310268-8q4tk6fd	154	23	for	for	IN
cord-310268-8q4tk6fd	154	24	the	the	DT
cord-310268-8q4tk6fd	154	25	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	154	26	of	of	IN
cord-310268-8q4tk6fd	154	27	infections	infection	NNS
cord-310268-8q4tk6fd	154	28	that	that	WDT
cord-310268-8q4tk6fd	154	29	need	need	VBP
cord-310268-8q4tk6fd	154	30	point	point	NN
cord-310268-8q4tk6fd	154	31	-	-	HYPH
cord-310268-8q4tk6fd	154	32	of	of	IN
cord-310268-8q4tk6fd	154	33	-	-	HYPH
cord-310268-8q4tk6fd	154	34	care	care	NN
cord-310268-8q4tk6fd	154	35	testing	testing	NN
cord-310268-8q4tk6fd	154	36	,	,	,
cord-310268-8q4tk6fd	154	37	such	such	JJ
cord-310268-8q4tk6fd	154	38	as	as	IN
cord-310268-8q4tk6fd	154	39	infections	infection	NNS
cord-310268-8q4tk6fd	154	40	caused	cause	VBN
cord-310268-8q4tk6fd	154	41	by	by	IN
cord-310268-8q4tk6fd	154	42	highly	highly	RB
cord-310268-8q4tk6fd	154	43	pathogenic	pathogenic	JJ
cord-310268-8q4tk6fd	154	44	pandemic	pandemic	NN
cord-310268-8q4tk6fd	154	45	influenza	influenza	NN
cord-310268-8q4tk6fd	154	46	virus	virus	NN
cord-310268-8q4tk6fd	154	47	,	,	,
cord-310268-8q4tk6fd	154	48	HIV	HIV	NNP
cord-310268-8q4tk6fd	154	49	,	,	,
cord-310268-8q4tk6fd	154	50	SARS	SARS	NNP
cord-310268-8q4tk6fd	154	51	-	-	HYPH
cord-310268-8q4tk6fd	154	52	CoV	CoV	NNP
cord-310268-8q4tk6fd	154	53	and	and	CC
cord-310268-8q4tk6fd	154	54	malaria	malaria	NN
cord-310268-8q4tk6fd	154	55	.	.	.
cord-310268-8q4tk6fd	155	1	Avian	avian	JJ
cord-310268-8q4tk6fd	155	2	influenza	influenza	NN
cord-310268-8q4tk6fd	155	3	virus	virus	NN
cord-310268-8q4tk6fd	155	4	H5N1	H5N1	NNP
cord-310268-8q4tk6fd	155	5	is	be	VBZ
cord-310268-8q4tk6fd	155	6	a	a	DT
cord-310268-8q4tk6fd	155	7	highly	highly	RB
cord-310268-8q4tk6fd	155	8	pathogenic	pathogenic	JJ
cord-310268-8q4tk6fd	155	9	subtype	subtype	NN
cord-310268-8q4tk6fd	155	10	of	of	IN
cord-310268-8q4tk6fd	155	11	the	the	DT
cord-310268-8q4tk6fd	155	12	influenza	influenza	NN
cord-310268-8q4tk6fd	155	13	virus	virus	NN
cord-310268-8q4tk6fd	155	14	,	,	,
cord-310268-8q4tk6fd	155	15	which	which	WDT
cord-310268-8q4tk6fd	155	16	can	can	MD
cord-310268-8q4tk6fd	155	17	also	also	RB
cord-310268-8q4tk6fd	155	18	infect	infect	VB
cord-310268-8q4tk6fd	155	19	humans	human	NNS
cord-310268-8q4tk6fd	155	20	and	and	CC
cord-310268-8q4tk6fd	155	21	has	have	VBZ
cord-310268-8q4tk6fd	155	22	a	a	DT
cord-310268-8q4tk6fd	155	23	high	high	JJ
cord-310268-8q4tk6fd	155	24	mortality	mortality	NN
cord-310268-8q4tk6fd	155	25	rate	rate	NN
cord-310268-8q4tk6fd	155	26	.	.	.
cord-310268-8q4tk6fd	156	1	Wang	Wang	NNP
cord-310268-8q4tk6fd	156	2	et	et	NNP
cord-310268-8q4tk6fd	156	3	al	al	NNP
cord-310268-8q4tk6fd	156	4	.	.	.
cord-310268-8q4tk6fd	157	1	selected	select	VBD
cord-310268-8q4tk6fd	157	2	a	a	DT
cord-310268-8q4tk6fd	157	3	DNA	dna	NN
cord-310268-8q4tk6fd	157	4	aptamer	aptamer	NN
cord-310268-8q4tk6fd	157	5	targeting	target	VBG
cord-310268-8q4tk6fd	157	6	H5N1	H5N1	NNP
cord-310268-8q4tk6fd	157	7	using	use	VBG
cord-310268-8q4tk6fd	157	8	both	both	CC
cord-310268-8q4tk6fd	157	9	the	the	DT
cord-310268-8q4tk6fd	157	10	virus	virus	NN
cord-310268-8q4tk6fd	157	11	antigen	antigen	NN
cord-310268-8q4tk6fd	157	12	and	and	CC
cord-310268-8q4tk6fd	157	13	the	the	DT
cord-310268-8q4tk6fd	157	14	whole	whole	JJ
cord-310268-8q4tk6fd	157	15	virus	virus	NN
cord-310268-8q4tk6fd	157	16	particle	particle	NN
cord-310268-8q4tk6fd	157	17	using	use	VBG
cord-310268-8q4tk6fd	157	18	the	the	DT
cord-310268-8q4tk6fd	157	19	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	157	20	method	method	NN
cord-310268-8q4tk6fd	157	21	[	[	-LRB-
cord-310268-8q4tk6fd	157	22	67	67	CD
cord-310268-8q4tk6fd	157	23	]	]	-RRB-
cord-310268-8q4tk6fd	157	24	.	.	.
cord-310268-8q4tk6fd	158	1	For	for	IN
cord-310268-8q4tk6fd	158	2	the	the	DT
cord-310268-8q4tk6fd	158	3	first	first	JJ
cord-310268-8q4tk6fd	158	4	four	four	CD
cord-310268-8q4tk6fd	158	5	selection	selection	NN
cord-310268-8q4tk6fd	158	6	cycles	cycle	NNS
cord-310268-8q4tk6fd	158	7	,	,	,
cord-310268-8q4tk6fd	158	8	the	the	DT
cord-310268-8q4tk6fd	158	9	purified	purify	VBN
cord-310268-8q4tk6fd	158	10	virus	virus	NN
cord-310268-8q4tk6fd	158	11	antigen	antigen	NN
cord-310268-8q4tk6fd	158	12	hemagglutinin	hemagglutinin	NN
cord-310268-8q4tk6fd	158	13	(	(	-LRB-
cord-310268-8q4tk6fd	158	14	HA	HA	NNP
cord-310268-8q4tk6fd	158	15	)	)	-RRB-
cord-310268-8q4tk6fd	158	16	was	be	VBD
cord-310268-8q4tk6fd	158	17	used	use	VBN
cord-310268-8q4tk6fd	158	18	as	as	IN
cord-310268-8q4tk6fd	158	19	the	the	DT
cord-310268-8q4tk6fd	158	20	target	target	NN
cord-310268-8q4tk6fd	158	21	protein	protein	NN
cord-310268-8q4tk6fd	158	22	,	,	,
cord-310268-8q4tk6fd	158	23	while	while	IN
cord-310268-8q4tk6fd	158	24	for	for	IN
cord-310268-8q4tk6fd	158	25	the	the	DT
cord-310268-8q4tk6fd	158	26	remaining	remain	VBG
cord-310268-8q4tk6fd	158	27	eight	eight	CD
cord-310268-8q4tk6fd	158	28	cycles	cycle	NNS
cord-310268-8q4tk6fd	158	29	the	the	DT
cord-310268-8q4tk6fd	158	30	entire	entire	JJ
cord-310268-8q4tk6fd	158	31	H5N1	H5N1	NNP
cord-310268-8q4tk6fd	158	32	virus	virus	NN
cord-310268-8q4tk6fd	158	33	particles	particle	NNS
cord-310268-8q4tk6fd	158	34	were	be	VBD
cord-310268-8q4tk6fd	158	35	used	use	VBN
cord-310268-8q4tk6fd	158	36	as	as	IN
cord-310268-8q4tk6fd	158	37	the	the	DT
cord-310268-8q4tk6fd	158	38	targets	target	NNS
cord-310268-8q4tk6fd	158	39	.	.	.
cord-310268-8q4tk6fd	159	1	The	the	DT
cord-310268-8q4tk6fd	159	2	selected	select	VBN
cord-310268-8q4tk6fd	159	3	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	159	4	showed	show	VBD
cord-310268-8q4tk6fd	159	5	high	high	JJ
cord-310268-8q4tk6fd	159	6	affinity	affinity	NN
cord-310268-8q4tk6fd	159	7	(	(	-LRB-
cord-310268-8q4tk6fd	159	8	K	k	NN
cord-310268-8q4tk6fd	159	9	d	d	NN
cord-310268-8q4tk6fd	159	10	=	=	NN
cord-310268-8q4tk6fd	159	11	4.6	4.6	CD
cord-310268-8q4tk6fd	159	12	nM	nM	NNP
cord-310268-8q4tk6fd	159	13	)	)	-RRB-
cord-310268-8q4tk6fd	159	14	and	and	CC
cord-310268-8q4tk6fd	159	15	specificity	specificity	NN
cord-310268-8q4tk6fd	159	16	to	to	IN
cord-310268-8q4tk6fd	159	17	the	the	DT
cord-310268-8q4tk6fd	159	18	H5N1	H5N1	NNP
cord-310268-8q4tk6fd	159	19	virus	virus	NN
cord-310268-8q4tk6fd	159	20	(	(	-LRB-
cord-310268-8q4tk6fd	159	21	Table	table	NN
cord-310268-8q4tk6fd	159	22	1	1	CD
cord-310268-8q4tk6fd	159	23	)	)	-RRB-
cord-310268-8q4tk6fd	159	24	.	.	.
cord-310268-8q4tk6fd	160	1	Using	use	VBG
cord-310268-8q4tk6fd	160	2	such	such	PDT
cord-310268-8q4tk6fd	160	3	a	a	DT
cord-310268-8q4tk6fd	160	4	mixed	mixed	JJ
cord-310268-8q4tk6fd	160	5	selection	selection	NN
cord-310268-8q4tk6fd	160	6	mode	mode	NN
cord-310268-8q4tk6fd	160	7	might	may	MD
cord-310268-8q4tk6fd	160	8	be	be	VB
cord-310268-8q4tk6fd	160	9	a	a	DT
cord-310268-8q4tk6fd	160	10	good	good	JJ
cord-310268-8q4tk6fd	160	11	strategy	strategy	NN
cord-310268-8q4tk6fd	160	12	to	to	TO
cord-310268-8q4tk6fd	160	13	obtain	obtain	VB
cord-310268-8q4tk6fd	160	14	ideal	ideal	JJ
cord-310268-8q4tk6fd	160	15	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	160	16	,	,	,
cord-310268-8q4tk6fd	160	17	which	which	WDT
cord-310268-8q4tk6fd	160	18	can	can	MD
cord-310268-8q4tk6fd	160	19	overcome	overcome	VB
cord-310268-8q4tk6fd	160	20	the	the	DT
cord-310268-8q4tk6fd	160	21	drawbacks	drawback	NNS
cord-310268-8q4tk6fd	160	22	of	of	IN
cord-310268-8q4tk6fd	160	23	selection	selection	NN
cord-310268-8q4tk6fd	160	24	using	use	VBG
cord-310268-8q4tk6fd	160	25	only	only	RB
cord-310268-8q4tk6fd	160	26	free	free	JJ
cord-310268-8q4tk6fd	160	27	biomarkers	biomarker	NNS
cord-310268-8q4tk6fd	160	28	or	or	CC
cord-310268-8q4tk6fd	160	29	cells	cell	NNS
cord-310268-8q4tk6fd	160	30	.	.	.
cord-310268-8q4tk6fd	161	1	In	in	IN
cord-310268-8q4tk6fd	161	2	the	the	DT
cord-310268-8q4tk6fd	161	3	case	case	NN
cord-310268-8q4tk6fd	161	4	of	of	IN
cord-310268-8q4tk6fd	161	5	cardiovascular	cardiovascular	JJ
cord-310268-8q4tk6fd	161	6	diseases	disease	NNS
cord-310268-8q4tk6fd	161	7	,	,	,
cord-310268-8q4tk6fd	161	8	markers	marker	NNS
cord-310268-8q4tk6fd	161	9	in	in	IN
cord-310268-8q4tk6fd	161	10	the	the	DT
cord-310268-8q4tk6fd	161	11	blood	blood	NN
cord-310268-8q4tk6fd	161	12	,	,	,
cord-310268-8q4tk6fd	161	13	such	such	JJ
cord-310268-8q4tk6fd	161	14	as	as	IN
cord-310268-8q4tk6fd	161	15	myoglobin	myoglobin	NN
cord-310268-8q4tk6fd	161	16	,	,	,
cord-310268-8q4tk6fd	161	17	C	c	NN
cord-310268-8q4tk6fd	161	18	-	-	HYPH
cord-310268-8q4tk6fd	161	19	reactive	reactive	JJ
cord-310268-8q4tk6fd	161	20	protein	protein	NN
cord-310268-8q4tk6fd	161	21	,	,	,
cord-310268-8q4tk6fd	161	22	L	l	NN
cord-310268-8q4tk6fd	161	23	-	-	HYPH
cord-310268-8q4tk6fd	161	24	homocysteine	homocysteine	NN
cord-310268-8q4tk6fd	161	25	and	and	CC
cord-310268-8q4tk6fd	161	26	thrombin	thrombin	NN
cord-310268-8q4tk6fd	161	27	have	have	VBP
cord-310268-8q4tk6fd	161	28	been	be	VBN
cord-310268-8q4tk6fd	161	29	used	use	VBN
cord-310268-8q4tk6fd	161	30	to	to	TO
cord-310268-8q4tk6fd	161	31	select	select	VB
cord-310268-8q4tk6fd	161	32	DNA	DNA	NNP
cord-310268-8q4tk6fd	161	33	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	161	34	for	for	IN
cord-310268-8q4tk6fd	161	35	the	the	DT
cord-310268-8q4tk6fd	161	36	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	161	37	of	of	IN
cord-310268-8q4tk6fd	161	38	related	related	JJ
cord-310268-8q4tk6fd	161	39	diseases	disease	NNS
cord-310268-8q4tk6fd	161	40	.	.	.
cord-310268-8q4tk6fd	162	1	Myoglobin	myoglobin	NN
cord-310268-8q4tk6fd	162	2	increases	increase	NNS
cord-310268-8q4tk6fd	162	3	after	after	IN
cord-310268-8q4tk6fd	162	4	acute	acute	JJ
cord-310268-8q4tk6fd	162	5	myocardial	myocardial	JJ
cord-310268-8q4tk6fd	162	6	infarction	infarction	NN
cord-310268-8q4tk6fd	162	7	,	,	,
cord-310268-8q4tk6fd	162	8	which	which	WDT
cord-310268-8q4tk6fd	162	9	is	be	VBZ
cord-310268-8q4tk6fd	162	10	an	an	DT
cord-310268-8q4tk6fd	162	11	important	important	JJ
cord-310268-8q4tk6fd	162	12	early	early	JJ
cord-310268-8q4tk6fd	162	13	marker	marker	NN
cord-310268-8q4tk6fd	162	14	in	in	IN
cord-310268-8q4tk6fd	162	15	urgent	urgent	JJ
cord-310268-8q4tk6fd	162	16	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	162	17	of	of	IN
cord-310268-8q4tk6fd	162	18	cardiovascular	cardiovascular	JJ
cord-310268-8q4tk6fd	162	19	diseases	disease	NNS
cord-310268-8q4tk6fd	162	20	.	.	.
cord-310268-8q4tk6fd	163	1	Wang	Wang	NNP
cord-310268-8q4tk6fd	163	2	et	et	NNP
cord-310268-8q4tk6fd	163	3	al	al	NNP
cord-310268-8q4tk6fd	163	4	.	.	.
cord-310268-8q4tk6fd	164	1	selected	select	VBN
cord-310268-8q4tk6fd	164	2	DNA	DNA	NNP
cord-310268-8q4tk6fd	164	3	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	164	4	against	against	IN
cord-310268-8q4tk6fd	164	5	myoglobin	myoglobin	NN
cord-310268-8q4tk6fd	164	6	using	use	VBG
cord-310268-8q4tk6fd	164	7	a	a	DT
cord-310268-8q4tk6fd	164	8	fluidic	fluidic	JJ
cord-310268-8q4tk6fd	164	9	chip	chip	NN
cord-310268-8q4tk6fd	164	10	method	method	NN
cord-310268-8q4tk6fd	164	11	[	[	-LRB-
cord-310268-8q4tk6fd	164	12	72	72	CD
cord-310268-8q4tk6fd	164	13	]	]	-RRB-
cord-310268-8q4tk6fd	164	14	.	.	.
cord-310268-8q4tk6fd	165	1	The	the	DT
cord-310268-8q4tk6fd	165	2	DNA	dna	NN
cord-310268-8q4tk6fd	165	3	aptamer	aptamer	NN
cord-310268-8q4tk6fd	165	4	with	with	IN
cord-310268-8q4tk6fd	165	5	the	the	DT
cord-310268-8q4tk6fd	165	6	lowest	low	JJS
cord-310268-8q4tk6fd	165	7	K	k	NN
cord-310268-8q4tk6fd	165	8	d	d	NN
cord-310268-8q4tk6fd	165	9	value	value	NN
cord-310268-8q4tk6fd	165	10	(	(	-LRB-
cord-310268-8q4tk6fd	165	11	4.93	4.93	CD
cord-310268-8q4tk6fd	165	12	nM	nM	NNP
cord-310268-8q4tk6fd	165	13	)	)	-RRB-
cord-310268-8q4tk6fd	165	14	was	be	VBD
cord-310268-8q4tk6fd	165	15	subjected	subject	VBN
cord-310268-8q4tk6fd	165	16	to	to	IN
cord-310268-8q4tk6fd	165	17	the	the	DT
cord-310268-8q4tk6fd	165	18	development	development	NN
cord-310268-8q4tk6fd	165	19	of	of	IN
cord-310268-8q4tk6fd	165	20	different	different	JJ
cord-310268-8q4tk6fd	165	21	biosensors	biosensor	NNS
cord-310268-8q4tk6fd	165	22	for	for	IN
cord-310268-8q4tk6fd	165	23	the	the	DT
cord-310268-8q4tk6fd	165	24	detection	detection	NN
cord-310268-8q4tk6fd	165	25	of	of	IN
cord-310268-8q4tk6fd	165	26	myoglobin	myoglobin	NN
cord-310268-8q4tk6fd	165	27	,	,	,
cord-310268-8q4tk6fd	165	28	including	include	VBG
cord-310268-8q4tk6fd	165	29	the	the	DT
cord-310268-8q4tk6fd	165	30	Myoglobin	Myoglobin	NNP
cord-310268-8q4tk6fd	165	31	-	-	HYPH
cord-310268-8q4tk6fd	165	32	induced	induce	VBN
cord-310268-8q4tk6fd	165	33	structural	structural	JJ
cord-310268-8q4tk6fd	165	34	switching	switch	VBG
cord-310268-8q4tk6fd	165	35	supersandwich	supersandwich	JJ
cord-310268-8q4tk6fd	165	36	biosensor	biosensor	NN
cord-310268-8q4tk6fd	165	37	[	[	-LRB-
cord-310268-8q4tk6fd	165	38	72	72	CD
cord-310268-8q4tk6fd	165	39	]	]	-RRB-
cord-310268-8q4tk6fd	165	40	and	and	CC
cord-310268-8q4tk6fd	165	41	the	the	DT
cord-310268-8q4tk6fd	165	42	antibody	antibody	NN
cord-310268-8q4tk6fd	165	43	-	-	HYPH
cord-310268-8q4tk6fd	165	44	Myoglobin	myoglobin	NN
cord-310268-8q4tk6fd	165	45	-	-	HYPH
cord-310268-8q4tk6fd	165	46	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	165	47	sandwich	sandwich	NN
cord-310268-8q4tk6fd	165	48	biosensor	biosensor	NN
cord-310268-8q4tk6fd	165	49	[	[	-LRB-
cord-310268-8q4tk6fd	165	50	76	76	CD
cord-310268-8q4tk6fd	165	51	]	]	-RRB-
cord-310268-8q4tk6fd	165	52	.	.	.
cord-310268-8q4tk6fd	166	1	Human	Human	NNP
cord-310268-8q4tk6fd	166	2	C	C	NNP
cord-310268-8q4tk6fd	166	3	-	-	HYPH
cord-310268-8q4tk6fd	166	4	reactive	reactive	JJ
cord-310268-8q4tk6fd	166	5	protein	protein	NN
cord-310268-8q4tk6fd	166	6	(	(	-LRB-
cord-310268-8q4tk6fd	166	7	CRP	CRP	NNP
cord-310268-8q4tk6fd	166	8	)	)	-RRB-
cord-310268-8q4tk6fd	166	9	is	be	VBZ
cord-310268-8q4tk6fd	166	10	a	a	DT
cord-310268-8q4tk6fd	166	11	homopentameric	homopentameric	JJ
cord-310268-8q4tk6fd	166	12	oligoprotein	oligoprotein	NN
cord-310268-8q4tk6fd	166	13	,	,	,
cord-310268-8q4tk6fd	166	14	which	which	WDT
cord-310268-8q4tk6fd	166	15	has	have	VBZ
cord-310268-8q4tk6fd	166	16	been	be	VBN
cord-310268-8q4tk6fd	166	17	validated	validate	VBN
cord-310268-8q4tk6fd	166	18	as	as	IN
cord-310268-8q4tk6fd	166	19	a	a	DT
cord-310268-8q4tk6fd	166	20	powerful	powerful	JJ
cord-310268-8q4tk6fd	166	21	predictor	predictor	NN
cord-310268-8q4tk6fd	166	22	and	and	CC
cord-310268-8q4tk6fd	166	23	risk	risk	NN
cord-310268-8q4tk6fd	166	24	factor	factor	NN
cord-310268-8q4tk6fd	166	25	of	of	IN
cord-310268-8q4tk6fd	166	26	inflammation	inflammation	NN
cord-310268-8q4tk6fd	166	27	and	and	CC
cord-310268-8q4tk6fd	166	28	cardiovascular	cardiovascular	JJ
cord-310268-8q4tk6fd	166	29	disease	disease	NN
cord-310268-8q4tk6fd	166	30	[	[	-LRB-
cord-310268-8q4tk6fd	166	31	77	77	CD
cord-310268-8q4tk6fd	166	32	]	]	-RRB-
cord-310268-8q4tk6fd	166	33	.	.	.
cord-310268-8q4tk6fd	167	1	Yang	Yang	NNP
cord-310268-8q4tk6fd	167	2	et	et	NNP
cord-310268-8q4tk6fd	167	3	al	al	NNP
cord-310268-8q4tk6fd	167	4	.	.	.
cord-310268-8q4tk6fd	168	1	selected	select	VBD
cord-310268-8q4tk6fd	168	2	a	a	DT
cord-310268-8q4tk6fd	168	3	DNA	dna	NN
cord-310268-8q4tk6fd	168	4	aptamer	aptamer	NN
cord-310268-8q4tk6fd	168	5	(	(	-LRB-
cord-310268-8q4tk6fd	168	6	K	K	NNP
cord-310268-8q4tk6fd	168	7	d	d	NN
cord-310268-8q4tk6fd	168	8	=	=	NN
cord-310268-8q4tk6fd	168	9	3.9	3.9	CD
cord-310268-8q4tk6fd	168	10	nM	nM	NNP
cord-310268-8q4tk6fd	168	11	)	)	-RRB-
cord-310268-8q4tk6fd	168	12	targeting	target	VBG
cord-310268-8q4tk6fd	168	13	CRP	crp	NN
cord-310268-8q4tk6fd	168	14	and	and	CC
cord-310268-8q4tk6fd	168	15	used	use	VBD
cord-310268-8q4tk6fd	168	16	it	-PRON-	PRP
cord-310268-8q4tk6fd	168	17	to	to	TO
cord-310268-8q4tk6fd	168	18	develop	develop	VB
cord-310268-8q4tk6fd	168	19	a	a	DT
cord-310268-8q4tk6fd	168	20	sensor	sensor	NN
cord-310268-8q4tk6fd	168	21	based	base	VBN
cord-310268-8q4tk6fd	168	22	on	on	IN
cord-310268-8q4tk6fd	168	23	surface	surface	NN
cord-310268-8q4tk6fd	168	24	plasmon	plasmon	JJ
cord-310268-8q4tk6fd	168	25	resonance	resonance	NN
cord-310268-8q4tk6fd	168	26	technology	technology	NN
cord-310268-8q4tk6fd	168	27	[	[	-LRB-
cord-310268-8q4tk6fd	168	28	78	78	CD
cord-310268-8q4tk6fd	168	29	]	]	-RRB-
cord-310268-8q4tk6fd	168	30	.	.	.
cord-310268-8q4tk6fd	169	1	L	L	NNP
cord-310268-8q4tk6fd	169	2	-	-	HYPH
cord-310268-8q4tk6fd	169	3	Homocysteine	Homocysteine	NNP
cord-310268-8q4tk6fd	169	4	is	be	VBZ
cord-310268-8q4tk6fd	169	5	an	an	DT
cord-310268-8q4tk6fd	169	6	amino	amino	NN
cord-310268-8q4tk6fd	169	7	acid	acid	NN
cord-310268-8q4tk6fd	169	8	intermediate	intermediate	JJ
cord-310268-8q4tk6fd	169	9	,	,	,
cord-310268-8q4tk6fd	169	10	whose	whose	WP$
cord-310268-8q4tk6fd	169	11	elevated	elevated	JJ
cord-310268-8q4tk6fd	169	12	level	level	NN
cord-310268-8q4tk6fd	169	13	in	in	IN
cord-310268-8q4tk6fd	169	14	the	the	DT
cord-310268-8q4tk6fd	169	15	blood	blood	NN
cord-310268-8q4tk6fd	169	16	is	be	VBZ
cord-310268-8q4tk6fd	169	17	associated	associate	VBN
cord-310268-8q4tk6fd	169	18	with	with	IN
cord-310268-8q4tk6fd	169	19	coronary	coronary	JJ
cord-310268-8q4tk6fd	169	20	heart	heart	NN
cord-310268-8q4tk6fd	169	21	disease	disease	NN
cord-310268-8q4tk6fd	169	22	[	[	-LRB-
cord-310268-8q4tk6fd	169	23	79	79	CD
cord-310268-8q4tk6fd	169	24	]	]	-RRB-
cord-310268-8q4tk6fd	169	25	.	.	.
cord-310268-8q4tk6fd	170	1	McKeague	McKeague	NNP
cord-310268-8q4tk6fd	170	2	et	et	NNP
cord-310268-8q4tk6fd	170	3	al	al	NNP
cord-310268-8q4tk6fd	170	4	.	.	.
cord-310268-8q4tk6fd	171	1	selected	select	VBN
cord-310268-8q4tk6fd	171	2	DNA	DNA	NNP
cord-310268-8q4tk6fd	171	3	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	171	4	targeting	target	VBG
cord-310268-8q4tk6fd	171	5	L	l	NN
cord-310268-8q4tk6fd	171	6	-	-	HYPH
cord-310268-8q4tk6fd	171	7	homocysteine	homocysteine	NN
cord-310268-8q4tk6fd	171	8	and	and	CC
cord-310268-8q4tk6fd	171	9	developed	develop	VBD
cord-310268-8q4tk6fd	171	10	an	an	DT
cord-310268-8q4tk6fd	171	11	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	171	12	-	-	HYPH
cord-310268-8q4tk6fd	171	13	AuNP	aunp	NN
cord-310268-8q4tk6fd	171	14	sensor	sensor	NN
cord-310268-8q4tk6fd	171	15	,	,	,
cord-310268-8q4tk6fd	171	16	in	in	IN
cord-310268-8q4tk6fd	171	17	which	which	WDT
cord-310268-8q4tk6fd	171	18	the	the	DT
cord-310268-8q4tk6fd	171	19	DNA	DNA	NNP
cord-310268-8q4tk6fd	171	20	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	171	21	first	first	JJ
cord-310268-8q4tk6fd	171	22	coil	coil	NN
cord-310268-8q4tk6fd	171	23	around	around	IN
cord-310268-8q4tk6fd	171	24	the	the	DT
cord-310268-8q4tk6fd	171	25	surface	surface	NN
cord-310268-8q4tk6fd	171	26	of	of	IN
cord-310268-8q4tk6fd	171	27	the	the	DT
cord-310268-8q4tk6fd	171	28	gold	gold	NN
cord-310268-8q4tk6fd	171	29	particles	particle	NNS
cord-310268-8q4tk6fd	171	30	and	and	CC
cord-310268-8q4tk6fd	171	31	release	release	VB
cord-310268-8q4tk6fd	171	32	the	the	DT
cord-310268-8q4tk6fd	171	33	particles	particle	NNS
cord-310268-8q4tk6fd	171	34	after	after	IN
cord-310268-8q4tk6fd	171	35	binding	bind	VBG
cord-310268-8q4tk6fd	171	36	to	to	IN
cord-310268-8q4tk6fd	171	37	the	the	DT
cord-310268-8q4tk6fd	171	38	homocysteine	homocysteine	NN
cord-310268-8q4tk6fd	171	39	,	,	,
cord-310268-8q4tk6fd	171	40	which	which	WDT
cord-310268-8q4tk6fd	171	41	leads	lead	VBZ
cord-310268-8q4tk6fd	171	42	to	to	IN
cord-310268-8q4tk6fd	171	43	salt	salt	NN
cord-310268-8q4tk6fd	171	44	-	-	HYPH
cord-310268-8q4tk6fd	171	45	induced	induce	VBN
cord-310268-8q4tk6fd	171	46	aggregation	aggregation	NN
cord-310268-8q4tk6fd	171	47	and	and	CC
cord-310268-8q4tk6fd	171	48	colorization	colorization	NN
cord-310268-8q4tk6fd	171	49	of	of	IN
cord-310268-8q4tk6fd	171	50	the	the	DT
cord-310268-8q4tk6fd	171	51	particles	particle	NNS
cord-310268-8q4tk6fd	171	52	[	[	-LRB-
cord-310268-8q4tk6fd	171	53	73	73	CD
cord-310268-8q4tk6fd	171	54	]	]	-RRB-
cord-310268-8q4tk6fd	171	55	.	.	.
cord-310268-8q4tk6fd	172	1	Thrombin	Thrombin	NNP
cord-310268-8q4tk6fd	172	2	is	be	VBZ
cord-310268-8q4tk6fd	172	3	a	a	DT
cord-310268-8q4tk6fd	172	4	serine	serine	NN
cord-310268-8q4tk6fd	172	5	protease	protease	NN
cord-310268-8q4tk6fd	172	6	that	that	WDT
cord-310268-8q4tk6fd	172	7	plays	play	VBZ
cord-310268-8q4tk6fd	172	8	a	a	DT
cord-310268-8q4tk6fd	172	9	critical	critical	JJ
cord-310268-8q4tk6fd	172	10	role	role	NN
cord-310268-8q4tk6fd	172	11	in	in	IN
cord-310268-8q4tk6fd	172	12	the	the	DT
cord-310268-8q4tk6fd	172	13	formation	formation	NN
cord-310268-8q4tk6fd	172	14	of	of	IN
cord-310268-8q4tk6fd	172	15	obstructive	obstructive	JJ
cord-310268-8q4tk6fd	172	16	blood	blood	NN
cord-310268-8q4tk6fd	172	17	clots	clot	NNS
cord-310268-8q4tk6fd	172	18	,	,	,
cord-310268-8q4tk6fd	172	19	or	or	CC
cord-310268-8q4tk6fd	172	20	thrombosis	thrombosis	NN
cord-310268-8q4tk6fd	172	21	,	,	,
cord-310268-8q4tk6fd	172	22	which	which	WDT
cord-310268-8q4tk6fd	172	23	is	be	VBZ
cord-310268-8q4tk6fd	172	24	involved	involve	VBN
cord-310268-8q4tk6fd	172	25	in	in	IN
cord-310268-8q4tk6fd	172	26	various	various	JJ
cord-310268-8q4tk6fd	172	27	diseases	disease	NNS
cord-310268-8q4tk6fd	172	28	including	include	VBG
cord-310268-8q4tk6fd	172	29	chronic	chronic	JJ
cord-310268-8q4tk6fd	172	30	cardiovascular	cardiovascular	JJ
cord-310268-8q4tk6fd	172	31	diseases	disease	NNS
cord-310268-8q4tk6fd	172	32	[	[	-LRB-
cord-310268-8q4tk6fd	172	33	80	80	CD
cord-310268-8q4tk6fd	172	34	]	]	-RRB-
cord-310268-8q4tk6fd	172	35	.	.	.
cord-310268-8q4tk6fd	173	1	The	the	DT
cord-310268-8q4tk6fd	173	2	first	first	JJ
cord-310268-8q4tk6fd	173	3	reported	report	VBN
cord-310268-8q4tk6fd	173	4	DNA	DNA	NNP
cord-310268-8q4tk6fd	173	5	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	173	6	is	be	VBZ
cord-310268-8q4tk6fd	173	7	the	the	DT
cord-310268-8q4tk6fd	173	8	thrombin	thrombin	NN
cord-310268-8q4tk6fd	173	9	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	173	10	.	.	.
cord-310268-8q4tk6fd	174	1	Since	since	IN
cord-310268-8q4tk6fd	174	2	then	then	RB
cord-310268-8q4tk6fd	174	3	,	,	,
cord-310268-8q4tk6fd	174	4	thrombin	thrombin	JJ
cord-310268-8q4tk6fd	174	5	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	174	6	have	have	VBP
cord-310268-8q4tk6fd	174	7	been	be	VBN
cord-310268-8q4tk6fd	174	8	used	use	VBN
cord-310268-8q4tk6fd	174	9	as	as	IN
cord-310268-8q4tk6fd	174	10	model	model	NN
cord-310268-8q4tk6fd	174	11	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	174	12	to	to	TO
cord-310268-8q4tk6fd	174	13	explore	explore	VB
cord-310268-8q4tk6fd	174	14	the	the	DT
cord-310268-8q4tk6fd	174	15	mode	mode	NN
cord-310268-8q4tk6fd	174	16	of	of	IN
cord-310268-8q4tk6fd	174	17	aptamer	aptamer	NN
cord-310268-8q4tk6fd	174	18	-	-	HYPH
cord-310268-8q4tk6fd	174	19	based	base	VBN
cord-310268-8q4tk6fd	174	20	biosensors	biosensor	NNS
cord-310268-8q4tk6fd	174	21	.	.	.
cord-310268-8q4tk6fd	175	1	It	-PRON-	PRP
cord-310268-8q4tk6fd	175	2	is	be	VBZ
cord-310268-8q4tk6fd	175	3	the	the	DT
cord-310268-8q4tk6fd	175	4	most	most	RBS
cord-310268-8q4tk6fd	175	5	frequently	frequently	RB
cord-310268-8q4tk6fd	175	6	used	use	VBN
cord-310268-8q4tk6fd	175	7	DNA	DNA	NNP
cord-310268-8q4tk6fd	175	8	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	175	9	for	for	IN
cord-310268-8q4tk6fd	175	10	the	the	DT
cord-310268-8q4tk6fd	175	11	demonstration	demonstration	NN
cord-310268-8q4tk6fd	175	12	of	of	IN
cord-310268-8q4tk6fd	175	13	the	the	DT
cord-310268-8q4tk6fd	175	14	proof	proof	NN
cord-310268-8q4tk6fd	175	15	-	-	HYPH
cord-310268-8q4tk6fd	175	16	of	of	IN
cord-310268-8q4tk6fd	175	17	-	-	HYPH
cord-310268-8q4tk6fd	175	18	principle	principle	NN
cord-310268-8q4tk6fd	175	19	of	of	IN
cord-310268-8q4tk6fd	175	20	various	various	JJ
cord-310268-8q4tk6fd	175	21	detection	detection	NN
cord-310268-8q4tk6fd	175	22	methods	method	NNS
cord-310268-8q4tk6fd	175	23	[	[	-LRB-
cord-310268-8q4tk6fd	175	24	81	81	CD
cord-310268-8q4tk6fd	175	25	]	]	-RRB-
cord-310268-8q4tk6fd	175	26	.	.	.
cord-310268-8q4tk6fd	176	1	The	the	DT
cord-310268-8q4tk6fd	176	2	general	general	JJ
cord-310268-8q4tk6fd	176	3	modalities	modality	NNS
cord-310268-8q4tk6fd	176	4	and	and	CC
cord-310268-8q4tk6fd	176	5	assay	assay	NN
cord-310268-8q4tk6fd	176	6	formats	format	NNS
cord-310268-8q4tk6fd	176	7	for	for	IN
cord-310268-8q4tk6fd	176	8	using	use	VBG
cord-310268-8q4tk6fd	176	9	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	176	10	in	in	IN
cord-310268-8q4tk6fd	176	11	sensors	sensor	NNS
cord-310268-8q4tk6fd	176	12	have	have	VBP
cord-310268-8q4tk6fd	176	13	been	be	VBN
cord-310268-8q4tk6fd	176	14	well	well	RB
cord-310268-8q4tk6fd	176	15	summarized	summarize	VBN
cord-310268-8q4tk6fd	176	16	in	in	IN
cord-310268-8q4tk6fd	176	17	many	many	JJ
cord-310268-8q4tk6fd	176	18	comprehensive	comprehensive	JJ
cord-310268-8q4tk6fd	176	19	reviews	review	NNS
cord-310268-8q4tk6fd	176	20	[	[	-LRB-
cord-310268-8q4tk6fd	176	21	82	82	CD
cord-310268-8q4tk6fd	176	22	]	]	-RRB-
cord-310268-8q4tk6fd	177	1	[	[	-LRB-
cord-310268-8q4tk6fd	177	2	83	83	CD
cord-310268-8q4tk6fd	177	3	]	]	-RRB-
cord-310268-8q4tk6fd	178	1	[	[	-LRB-
cord-310268-8q4tk6fd	178	2	84	84	CD
cord-310268-8q4tk6fd	178	3	]	]	-RRB-
cord-310268-8q4tk6fd	178	4	[	[	-LRB-
cord-310268-8q4tk6fd	178	5	85	85	CD
cord-310268-8q4tk6fd	178	6	]	]	-RRB-
cord-310268-8q4tk6fd	178	7	[	[	-LRB-
cord-310268-8q4tk6fd	178	8	86	86	CD
cord-310268-8q4tk6fd	178	9	]	]	-RRB-
cord-310268-8q4tk6fd	178	10	.	.	.
cord-310268-8q4tk6fd	179	1	They	-PRON-	PRP
cord-310268-8q4tk6fd	179	2	can	can	MD
cord-310268-8q4tk6fd	179	3	be	be	VB
cord-310268-8q4tk6fd	179	4	roughly	roughly	RB
cord-310268-8q4tk6fd	179	5	classified	classify	VBN
cord-310268-8q4tk6fd	179	6	into	into	IN
cord-310268-8q4tk6fd	179	7	four	four	CD
cord-310268-8q4tk6fd	179	8	types	type	NNS
cord-310268-8q4tk6fd	179	9	based	base	VBN
cord-310268-8q4tk6fd	179	10	on	on	IN
cord-310268-8q4tk6fd	179	11	the	the	DT
cord-310268-8q4tk6fd	179	12	way	way	NN
cord-310268-8q4tk6fd	179	13	the	the	DT
cord-310268-8q4tk6fd	179	14	signal	signal	NN
cord-310268-8q4tk6fd	179	15	is	be	VBZ
cord-310268-8q4tk6fd	179	16	generated	generate	VBN
cord-310268-8q4tk6fd	179	17	:	:	:
cord-310268-8q4tk6fd	179	18	(	(	-LRB-
cord-310268-8q4tk6fd	179	19	1	1	LS
cord-310268-8q4tk6fd	179	20	)	)	-RRB-
cord-310268-8q4tk6fd	179	21	direct	direct	JJ
cord-310268-8q4tk6fd	179	22	binding	binding	NN
cord-310268-8q4tk6fd	179	23	-	-	HYPH
cord-310268-8q4tk6fd	179	24	based	base	VBN
cord-310268-8q4tk6fd	179	25	mode	mode	NN
cord-310268-8q4tk6fd	179	26	;	;	:
cord-310268-8q4tk6fd	180	1	(	(	-LRB-
cord-310268-8q4tk6fd	180	2	2	2	LS
cord-310268-8q4tk6fd	180	3	)	)	-RRB-
cord-310268-8q4tk6fd	180	4	target	target	NN
cord-310268-8q4tk6fd	180	5	-	-	HYPH
cord-310268-8q4tk6fd	180	6	induced	induce	VBN
cord-310268-8q4tk6fd	180	7	structural	structural	JJ
cord-310268-8q4tk6fd	180	8	switching	switching	NN
cord-310268-8q4tk6fd	180	9	mode	mode	NN
cord-310268-8q4tk6fd	180	10	;	;	,
cord-310268-8q4tk6fd	180	11	(	(	-LRB-
cord-310268-8q4tk6fd	180	12	3	3	LS
cord-310268-8q4tk6fd	180	13	)	)	-RRB-
cord-310268-8q4tk6fd	180	14	sandwich	sandwich	NN
cord-310268-8q4tk6fd	180	15	-	-	HYPH
cord-310268-8q4tk6fd	180	16	like	like	JJ
cord-310268-8q4tk6fd	180	17	mode	mode	NN
cord-310268-8q4tk6fd	180	18	;	;	:
cord-310268-8q4tk6fd	180	19	and	and	CC
cord-310268-8q4tk6fd	180	20	(	(	-LRB-
cord-310268-8q4tk6fd	180	21	4	4	LS
cord-310268-8q4tk6fd	180	22	)	)	-RRB-
cord-310268-8q4tk6fd	180	23	target	target	VB
cord-310268-8q4tk6fd	180	24	-	-	HYPH
cord-310268-8q4tk6fd	180	25	induced	induce	VBN
cord-310268-8q4tk6fd	180	26	assembly	assembly	NN
cord-310268-8q4tk6fd	180	27	or	or	CC
cord-310268-8q4tk6fd	180	28	dissociation	dissociation	NN
cord-310268-8q4tk6fd	180	29	mode	mode	NN
cord-310268-8q4tk6fd	180	30	.	.	.
cord-310268-8q4tk6fd	181	1	These	these	DT
cord-310268-8q4tk6fd	181	2	protocols	protocol	NNS
cord-310268-8q4tk6fd	181	3	are	be	VBP
cord-310268-8q4tk6fd	181	4	illustrated	illustrate	VBN
cord-310268-8q4tk6fd	181	5	in	in	IN
cord-310268-8q4tk6fd	181	6	Figure	figure	NN
cord-310268-8q4tk6fd	181	7	2	2	CD
cord-310268-8q4tk6fd	181	8	.	.	.
cord-310268-8q4tk6fd	182	1	In	in	IN
cord-310268-8q4tk6fd	182	2	the	the	DT
cord-310268-8q4tk6fd	182	3	direct	direct	JJ
cord-310268-8q4tk6fd	182	4	binding	binding	NN
cord-310268-8q4tk6fd	182	5	-	-	HYPH
cord-310268-8q4tk6fd	182	6	based	base	VBN
cord-310268-8q4tk6fd	182	7	mode	mode	NN
cord-310268-8q4tk6fd	182	8	(	(	-LRB-
cord-310268-8q4tk6fd	182	9	Figure	figure	NN
cord-310268-8q4tk6fd	182	10	2A	2a	CD
cord-310268-8q4tk6fd	182	11	)	)	-RRB-
cord-310268-8q4tk6fd	182	12	,	,	,
cord-310268-8q4tk6fd	182	13	aptamers	aptamers	NNP
cord-310268-8q4tk6fd	182	14	labeled	label	VBN
cord-310268-8q4tk6fd	182	15	with	with	IN
cord-310268-8q4tk6fd	182	16	signal	signal	NN
cord-310268-8q4tk6fd	182	17	molecules	molecule	NNS
cord-310268-8q4tk6fd	182	18	directly	directly	RB
cord-310268-8q4tk6fd	182	19	bind	bind	VBP
cord-310268-8q4tk6fd	182	20	to	to	IN
cord-310268-8q4tk6fd	182	21	the	the	DT
cord-310268-8q4tk6fd	182	22	target	target	NN
cord-310268-8q4tk6fd	182	23	.	.	.
cord-310268-8q4tk6fd	183	1	The	the	DT
cord-310268-8q4tk6fd	183	2	signal	signal	NN
cord-310268-8q4tk6fd	183	3	molecules	molecule	NNS
cord-310268-8q4tk6fd	183	4	on	on	IN
cord-310268-8q4tk6fd	183	5	the	the	DT
cord-310268-8q4tk6fd	183	6	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	183	7	-	-	HYPH
cord-310268-8q4tk6fd	183	8	bound	bind	VBN
cord-310268-8q4tk6fd	183	9	target	target	NN
cord-310268-8q4tk6fd	183	10	can	can	MD
cord-310268-8q4tk6fd	183	11	be	be	VB
cord-310268-8q4tk6fd	183	12	detected	detect	VBN
cord-310268-8q4tk6fd	183	13	directly	directly	RB
cord-310268-8q4tk6fd	183	14	.	.	.
cord-310268-8q4tk6fd	184	1	The	the	DT
cord-310268-8q4tk6fd	184	2	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	184	3	for	for	IN
cord-310268-8q4tk6fd	184	4	cancer	cancer	NN
cord-310268-8q4tk6fd	184	5	cells	cell	NNS
cord-310268-8q4tk6fd	184	6	imaging	image	VBG
cord-310268-8q4tk6fd	184	7	usually	usually	RB
cord-310268-8q4tk6fd	184	8	use	use	VBP
cord-310268-8q4tk6fd	184	9	this	this	DT
cord-310268-8q4tk6fd	184	10	mode	mode	NN
cord-310268-8q4tk6fd	184	11	(	(	-LRB-
cord-310268-8q4tk6fd	184	12	Table	table	NN
cord-310268-8q4tk6fd	184	13	1	1	CD
cord-310268-8q4tk6fd	184	14	)	)	-RRB-
cord-310268-8q4tk6fd	184	15	.	.	.
cord-310268-8q4tk6fd	185	1	It	-PRON-	PRP
cord-310268-8q4tk6fd	185	2	is	be	VBZ
cord-310268-8q4tk6fd	185	3	a	a	DT
cord-310268-8q4tk6fd	185	4	simple	simple	JJ
cord-310268-8q4tk6fd	185	5	and	and	CC
cord-310268-8q4tk6fd	185	6	direct	direct	JJ
cord-310268-8q4tk6fd	185	7	mode	mode	NN
cord-310268-8q4tk6fd	185	8	,	,	,
cord-310268-8q4tk6fd	185	9	which	which	WDT
cord-310268-8q4tk6fd	185	10	is	be	VBZ
cord-310268-8q4tk6fd	185	11	especially	especially	RB
cord-310268-8q4tk6fd	185	12	suitable	suitable	JJ
cord-310268-8q4tk6fd	185	13	for	for	IN
cord-310268-8q4tk6fd	185	14	the	the	DT
cord-310268-8q4tk6fd	185	15	situations	situation	NNS
cord-310268-8q4tk6fd	185	16	like	like	IN
cord-310268-8q4tk6fd	185	17	in	in	IN
cord-310268-8q4tk6fd	185	18	vivo	vivo	NN
cord-310268-8q4tk6fd	185	19	imaging	imaging	NN
cord-310268-8q4tk6fd	185	20	that	that	WDT
cord-310268-8q4tk6fd	185	21	do	do	VBP
cord-310268-8q4tk6fd	185	22	not	not	RB
cord-310268-8q4tk6fd	185	23	allow	allow	VB
cord-310268-8q4tk6fd	185	24	complex	complex	JJ
cord-310268-8q4tk6fd	185	25	detection	detection	NN
cord-310268-8q4tk6fd	185	26	.	.	.
cord-310268-8q4tk6fd	186	1	But	but	CC
cord-310268-8q4tk6fd	186	2	it	-PRON-	PRP
cord-310268-8q4tk6fd	186	3	does	do	VBZ
cord-310268-8q4tk6fd	186	4	not	not	RB
cord-310268-8q4tk6fd	186	5	contain	contain	VB
cord-310268-8q4tk6fd	186	6	signal	signal	JJ
cord-310268-8q4tk6fd	186	7	amplification	amplification	NN
cord-310268-8q4tk6fd	186	8	,	,	,
cord-310268-8q4tk6fd	186	9	which	which	WDT
cord-310268-8q4tk6fd	186	10	makes	make	VBZ
cord-310268-8q4tk6fd	186	11	it	-PRON-	PRP
cord-310268-8q4tk6fd	186	12	difficult	difficult	JJ
cord-310268-8q4tk6fd	186	13	to	to	TO
cord-310268-8q4tk6fd	186	14	increase	increase	VB
cord-310268-8q4tk6fd	186	15	the	the	DT
cord-310268-8q4tk6fd	186	16	detection	detection	NN
cord-310268-8q4tk6fd	186	17	sensitivity	sensitivity	NN
cord-310268-8q4tk6fd	186	18	.	.	.
cord-310268-8q4tk6fd	187	1	In	in	IN
cord-310268-8q4tk6fd	187	2	target	target	NN
cord-310268-8q4tk6fd	187	3	-	-	HYPH
cord-310268-8q4tk6fd	187	4	induced	induce	VBN
cord-310268-8q4tk6fd	187	5	structural	structural	JJ
cord-310268-8q4tk6fd	187	6	switching	switching	NN
cord-310268-8q4tk6fd	187	7	mode	mode	NN
cord-310268-8q4tk6fd	187	8	,	,	,
cord-310268-8q4tk6fd	187	9	the	the	DT
cord-310268-8q4tk6fd	187	10	binding	binding	NN
cord-310268-8q4tk6fd	187	11	of	of	IN
cord-310268-8q4tk6fd	187	12	the	the	DT
cord-310268-8q4tk6fd	187	13	target	target	NN
cord-310268-8q4tk6fd	187	14	will	will	MD
cord-310268-8q4tk6fd	187	15	cause	cause	VB
cord-310268-8q4tk6fd	187	16	a	a	DT
cord-310268-8q4tk6fd	187	17	specific	specific	JJ
cord-310268-8q4tk6fd	187	18	conformational	conformational	JJ
cord-310268-8q4tk6fd	187	19	change	change	NN
cord-310268-8q4tk6fd	187	20	to	to	IN
cord-310268-8q4tk6fd	187	21	the	the	DT
cord-310268-8q4tk6fd	187	22	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	187	23	,	,	,
cord-310268-8q4tk6fd	187	24	which	which	WDT
cord-310268-8q4tk6fd	187	25	will	will	MD
cord-310268-8q4tk6fd	187	26	"	"	``
cord-310268-8q4tk6fd	187	27	switch	switch	VB
cord-310268-8q4tk6fd	187	28	on	on	RP
cord-310268-8q4tk6fd	187	29	or	or	CC
cord-310268-8q4tk6fd	187	30	switch	switch	VB
cord-310268-8q4tk6fd	187	31	off	off	RP
cord-310268-8q4tk6fd	187	32	"	"	``
cord-310268-8q4tk6fd	187	33	the	the	DT
cord-310268-8q4tk6fd	187	34	signal	signal	JJ
cord-310268-8q4tk6fd	187	35	generation	generation	NN
cord-310268-8q4tk6fd	187	36	[	[	-LRB-
cord-310268-8q4tk6fd	187	37	87	87	CD
cord-310268-8q4tk6fd	187	38	,	,	,
cord-310268-8q4tk6fd	187	39	88	88	CD
cord-310268-8q4tk6fd	187	40	]	]	-RRB-
cord-310268-8q4tk6fd	187	41	.	.	.
cord-310268-8q4tk6fd	188	1	For	for	IN
cord-310268-8q4tk6fd	188	2	example	example	NN
cord-310268-8q4tk6fd	188	3	,	,	,
cord-310268-8q4tk6fd	188	4	in	in	IN
cord-310268-8q4tk6fd	188	5	a	a	DT
cord-310268-8q4tk6fd	188	6	bio	bio	JJ
cord-310268-8q4tk6fd	188	7	-	-	JJ
cord-310268-8q4tk6fd	188	8	chromophoric	chromophoric	JJ
cord-310268-8q4tk6fd	188	9	target	target	NN
cord-310268-8q4tk6fd	188	10	-	-	HYPH
cord-310268-8q4tk6fd	188	11	induced	induce	VBN
cord-310268-8q4tk6fd	188	12	structural	structural	JJ
cord-310268-8q4tk6fd	188	13	switching	switching	NN
cord-310268-8q4tk6fd	188	14	approach	approach	NN
cord-310268-8q4tk6fd	188	15	,	,	,
cord-310268-8q4tk6fd	188	16	a	a	DT
cord-310268-8q4tk6fd	188	17	fluorophore	fluorophore	RB
cord-310268-8q4tk6fd	188	18	-	-	HYPH
cord-310268-8q4tk6fd	188	19	labeled	label	VBN
cord-310268-8q4tk6fd	188	20	DNA	DNA	NNP
cord-310268-8q4tk6fd	188	21	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	188	22	forms	form	VBZ
cord-310268-8q4tk6fd	188	23	a	a	DT
cord-310268-8q4tk6fd	188	24	partial	partial	JJ
cord-310268-8q4tk6fd	188	25	duplex	duplex	NN
cord-310268-8q4tk6fd	188	26	with	with	IN
cord-310268-8q4tk6fd	188	27	a	a	DT
cord-310268-8q4tk6fd	188	28	small	small	JJ
cord-310268-8q4tk6fd	188	29	oligonucleotide	oligonucleotide	NN
cord-310268-8q4tk6fd	188	30	modified	modify	VBN
cord-310268-8q4tk6fd	188	31	with	with	IN
cord-310268-8q4tk6fd	188	32	a	a	DT
cord-310268-8q4tk6fd	188	33	quenching	quenching	NN
cord-310268-8q4tk6fd	188	34	moiety	moiety	NN
cord-310268-8q4tk6fd	188	35	(	(	-LRB-
cord-310268-8q4tk6fd	188	36	denoted	denote	VBN
cord-310268-8q4tk6fd	188	37	QDNA	QDNA	NNP
cord-310268-8q4tk6fd	188	38	)	)	-RRB-
cord-310268-8q4tk6fd	188	39	in	in	IN
cord-310268-8q4tk6fd	188	40	the	the	DT
cord-310268-8q4tk6fd	188	41	absence	absence	NN
cord-310268-8q4tk6fd	188	42	of	of	IN
cord-310268-8q4tk6fd	188	43	the	the	DT
cord-310268-8q4tk6fd	188	44	target	target	NN
cord-310268-8q4tk6fd	188	45	,	,	,
cord-310268-8q4tk6fd	188	46	bringing	bring	VBG
cord-310268-8q4tk6fd	188	47	the	the	DT
cord-310268-8q4tk6fd	188	48	fluorophore	fluorophore	NN
cord-310268-8q4tk6fd	188	49	(	(	-LRB-
cord-310268-8q4tk6fd	188	50	F	F	NNP
cord-310268-8q4tk6fd	188	51	)	)	-RRB-
cord-310268-8q4tk6fd	188	52	and	and	CC
cord-310268-8q4tk6fd	188	53	the	the	DT
cord-310268-8q4tk6fd	188	54	quencher	quencher	NN
cord-310268-8q4tk6fd	188	55	(	(	-LRB-
cord-310268-8q4tk6fd	188	56	Q	Q	NNP
cord-310268-8q4tk6fd	188	57	)	)	-RRB-
cord-310268-8q4tk6fd	188	58	into	into	IN
cord-310268-8q4tk6fd	188	59	close	close	JJ
cord-310268-8q4tk6fd	188	60	proximity	proximity	NN
cord-310268-8q4tk6fd	188	61	for	for	IN
cord-310268-8q4tk6fd	188	62	maximum	maximum	JJ
cord-310268-8q4tk6fd	188	63	fluorescence	fluorescence	NN
cord-310268-8q4tk6fd	188	64	quenching	quenching	NN
cord-310268-8q4tk6fd	188	65	.	.	.
cord-310268-8q4tk6fd	189	1	When	when	WRB
cord-310268-8q4tk6fd	189	2	the	the	DT
cord-310268-8q4tk6fd	189	3	target	target	NN
cord-310268-8q4tk6fd	189	4	is	be	VBZ
cord-310268-8q4tk6fd	189	5	introduced	introduce	VBN
cord-310268-8q4tk6fd	189	6	,	,	,
cord-310268-8q4tk6fd	189	7	the	the	DT
cord-310268-8q4tk6fd	189	8	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	189	9	prefers	prefer	VBZ
cord-310268-8q4tk6fd	189	10	to	to	TO
cord-310268-8q4tk6fd	189	11	form	form	VB
cord-310268-8q4tk6fd	189	12	the	the	DT
cord-310268-8q4tk6fd	189	13	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	189	14	-	-	HYPH
cord-310268-8q4tk6fd	189	15	target	target	NN
cord-310268-8q4tk6fd	189	16	complex	complex	NN
cord-310268-8q4tk6fd	189	17	.	.	.
cord-310268-8q4tk6fd	190	1	The	the	DT
cord-310268-8q4tk6fd	190	2	binding	binding	NN
cord-310268-8q4tk6fd	190	3	of	of	IN
cord-310268-8q4tk6fd	190	4	the	the	DT
cord-310268-8q4tk6fd	190	5	target	target	NN
cord-310268-8q4tk6fd	190	6	to	to	IN
cord-310268-8q4tk6fd	190	7	the	the	DT
cord-310268-8q4tk6fd	190	8	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	190	9	will	will	MD
cord-310268-8q4tk6fd	190	10	change	change	VB
cord-310268-8q4tk6fd	190	11	the	the	DT
cord-310268-8q4tk6fd	190	12	structure	structure	NN
cord-310268-8q4tk6fd	190	13	of	of	IN
cord-310268-8q4tk6fd	190	14	the	the	DT
cord-310268-8q4tk6fd	190	15	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	190	16	and	and	CC
cord-310268-8q4tk6fd	190	17	release	release	VB
cord-310268-8q4tk6fd	190	18	the	the	DT
cord-310268-8q4tk6fd	190	19	partially	partially	RB
cord-310268-8q4tk6fd	190	20	complementary	complementary	JJ
cord-310268-8q4tk6fd	190	21	quencher	quencher	NN
cord-310268-8q4tk6fd	190	22	,	,	,
cord-310268-8q4tk6fd	190	23	which	which	WDT
cord-310268-8q4tk6fd	190	24	will	will	MD
cord-310268-8q4tk6fd	190	25	trigger	trigger	VB
cord-310268-8q4tk6fd	190	26	the	the	DT
cord-310268-8q4tk6fd	190	27	increase	increase	NN
cord-310268-8q4tk6fd	190	28	of	of	IN
cord-310268-8q4tk6fd	190	29	the	the	DT
cord-310268-8q4tk6fd	190	30	signal	signal	NN
cord-310268-8q4tk6fd	190	31	(	(	-LRB-
cord-310268-8q4tk6fd	190	32	Figure	figure	NN
cord-310268-8q4tk6fd	190	33	2B	2b	CD
cord-310268-8q4tk6fd	190	34	)	)	-RRB-
cord-310268-8q4tk6fd	190	35	.	.	.
cord-310268-8q4tk6fd	191	1	This	this	DT
cord-310268-8q4tk6fd	191	2	mode	mode	NN
cord-310268-8q4tk6fd	191	3	is	be	VBZ
cord-310268-8q4tk6fd	191	4	suited	suit	VBN
cord-310268-8q4tk6fd	191	5	for	for	IN
cord-310268-8q4tk6fd	191	6	the	the	DT
cord-310268-8q4tk6fd	191	7	development	development	NN
cord-310268-8q4tk6fd	191	8	of	of	IN
cord-310268-8q4tk6fd	191	9	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	191	10	-	-	HYPH
cord-310268-8q4tk6fd	191	11	based	base	VBN
cord-310268-8q4tk6fd	191	12	reporters	reporter	NNS
cord-310268-8q4tk6fd	191	13	for	for	IN
cord-310268-8q4tk6fd	191	14	real	real	JJ
cord-310268-8q4tk6fd	191	15	-	-	HYPH
cord-310268-8q4tk6fd	191	16	time	time	NN
cord-310268-8q4tk6fd	191	17	sensing	sensing	NN
cord-310268-8q4tk6fd	191	18	applications	application	NNS
cord-310268-8q4tk6fd	191	19	.	.	.
cord-310268-8q4tk6fd	192	1	But	but	CC
cord-310268-8q4tk6fd	192	2	the	the	DT
cord-310268-8q4tk6fd	192	3	limitation	limitation	NN
cord-310268-8q4tk6fd	192	4	of	of	IN
cord-310268-8q4tk6fd	192	5	this	this	DT
cord-310268-8q4tk6fd	192	6	mode	mode	NN
cord-310268-8q4tk6fd	192	7	is	be	VBZ
cord-310268-8q4tk6fd	192	8	the	the	DT
cord-310268-8q4tk6fd	192	9	decreased	decrease	VBN
cord-310268-8q4tk6fd	192	10	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	192	11	binding	bind	VBG
cord-310268-8q4tk6fd	192	12	affinity	affinity	NN
cord-310268-8q4tk6fd	192	13	because	because	IN
cord-310268-8q4tk6fd	192	14	of	of	IN
cord-310268-8q4tk6fd	192	15	competition	competition	NN
cord-310268-8q4tk6fd	192	16	from	from	IN
cord-310268-8q4tk6fd	192	17	the	the	DT
cord-310268-8q4tk6fd	192	18	QDNA	QDNA	NNP
cord-310268-8q4tk6fd	192	19	[	[	-LRB-
cord-310268-8q4tk6fd	192	20	87	87	CD
cord-310268-8q4tk6fd	192	21	]	]	-RRB-
cord-310268-8q4tk6fd	192	22	.	.	.
cord-310268-8q4tk6fd	193	1	In	in	IN
cord-310268-8q4tk6fd	193	2	the	the	DT
cord-310268-8q4tk6fd	193	3	sandwich	sandwich	NN
cord-310268-8q4tk6fd	193	4	-	-	HYPH
cord-310268-8q4tk6fd	193	5	like	like	JJ
cord-310268-8q4tk6fd	193	6	mode	mode	NN
cord-310268-8q4tk6fd	193	7	,	,	,
cord-310268-8q4tk6fd	193	8	the	the	DT
cord-310268-8q4tk6fd	193	9	target	target	NN
cord-310268-8q4tk6fd	193	10	is	be	VBZ
cord-310268-8q4tk6fd	193	11	"	"	``
cord-310268-8q4tk6fd	193	12	the	the	DT
cord-310268-8q4tk6fd	193	13	meat	meat	NN
cord-310268-8q4tk6fd	193	14	"	"	''
cord-310268-8q4tk6fd	193	15	inserted	insert	VBN
cord-310268-8q4tk6fd	193	16	within	within	IN
cord-310268-8q4tk6fd	193	17	"	"	``
cord-310268-8q4tk6fd	193	18	two	two	CD
cord-310268-8q4tk6fd	193	19	pieces	piece	NNS
cord-310268-8q4tk6fd	193	20	of	of	IN
cord-310268-8q4tk6fd	193	21	bread	bread	NN
cord-310268-8q4tk6fd	193	22	"	"	''
cord-310268-8q4tk6fd	193	23	consisting	consist	VBG
cord-310268-8q4tk6fd	193	24	of	of	IN
cord-310268-8q4tk6fd	193	25	an	an	DT
cord-310268-8q4tk6fd	193	26	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	193	27	/	/	SYM
cord-310268-8q4tk6fd	193	28	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	193	29	or	or	CC
cord-310268-8q4tk6fd	193	30	antibody	antibody	NN
cord-310268-8q4tk6fd	193	31	/	/	SYM
cord-310268-8q4tk6fd	193	32	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	193	33	,	,	,
cord-310268-8q4tk6fd	193	34	which	which	WDT
cord-310268-8q4tk6fd	193	35	is	be	VBZ
cord-310268-8q4tk6fd	193	36	very	very	RB
cord-310268-8q4tk6fd	193	37	similar	similar	JJ
cord-310268-8q4tk6fd	193	38	to	to	IN
cord-310268-8q4tk6fd	193	39	the	the	DT
cord-310268-8q4tk6fd	193	40	enzyme	enzyme	NN
cord-310268-8q4tk6fd	193	41	-	-	HYPH
cord-310268-8q4tk6fd	193	42	linked	link	VBN
cord-310268-8q4tk6fd	193	43	immunosorbent	immunosorbent	JJ
cord-310268-8q4tk6fd	193	44	assay	assay	NN
cord-310268-8q4tk6fd	193	45	(	(	-LRB-
cord-310268-8q4tk6fd	193	46	ELISA	ELISA	NNP
cord-310268-8q4tk6fd	193	47	)	)	-RRB-
cord-310268-8q4tk6fd	193	48	(	(	-LRB-
cord-310268-8q4tk6fd	193	49	Figure	figure	NN
cord-310268-8q4tk6fd	193	50	2C	2c	NN
cord-310268-8q4tk6fd	193	51	)	)	-RRB-
cord-310268-8q4tk6fd	193	52	.	.	.
cord-310268-8q4tk6fd	194	1	Aptamers	aptamer	NNS
cord-310268-8q4tk6fd	194	2	in	in	IN
cord-310268-8q4tk6fd	194	3	this	this	DT
cord-310268-8q4tk6fd	194	4	mode	mode	NN
cord-310268-8q4tk6fd	194	5	function	function	NN
cord-310268-8q4tk6fd	194	6	as	as	IN
cord-310268-8q4tk6fd	194	7	reporter	reporter	NN
cord-310268-8q4tk6fd	194	8	and/or	and/or	CC
cord-310268-8q4tk6fd	194	9	capturer	capturer	NN
cord-310268-8q4tk6fd	194	10	.	.	.
cord-310268-8q4tk6fd	195	1	This	this	DT
cord-310268-8q4tk6fd	195	2	method	method	NN
cord-310268-8q4tk6fd	195	3	permits	permit	VBZ
cord-310268-8q4tk6fd	195	4	double	double	JJ
cord-310268-8q4tk6fd	195	5	recognition	recognition	NN
cord-310268-8q4tk6fd	195	6	of	of	IN
cord-310268-8q4tk6fd	195	7	the	the	DT
cord-310268-8q4tk6fd	195	8	target	target	NN
cord-310268-8q4tk6fd	195	9	and	and	CC
cord-310268-8q4tk6fd	195	10	signal	signal	NN
cord-310268-8q4tk6fd	195	11	amplification	amplification	NN
cord-310268-8q4tk6fd	195	12	,	,	,
cord-310268-8q4tk6fd	195	13	which	which	WDT
cord-310268-8q4tk6fd	195	14	can	can	MD
cord-310268-8q4tk6fd	195	15	greatly	greatly	RB
cord-310268-8q4tk6fd	195	16	improve	improve	VB
cord-310268-8q4tk6fd	195	17	the	the	DT
cord-310268-8q4tk6fd	195	18	specificity	specificity	NN
cord-310268-8q4tk6fd	195	19	and	and	CC
cord-310268-8q4tk6fd	195	20	sensitivity	sensitivity	NN
cord-310268-8q4tk6fd	195	21	of	of	IN
cord-310268-8q4tk6fd	195	22	aptamer	aptamer	NN
cord-310268-8q4tk6fd	195	23	-	-	HYPH
cord-310268-8q4tk6fd	195	24	based	base	VBN
cord-310268-8q4tk6fd	195	25	detection	detection	NN
cord-310268-8q4tk6fd	195	26	.	.	.
cord-310268-8q4tk6fd	196	1	Moreover	moreover	RB
cord-310268-8q4tk6fd	196	2	,	,	,
cord-310268-8q4tk6fd	196	3	because	because	IN
cord-310268-8q4tk6fd	196	4	of	of	IN
cord-310268-8q4tk6fd	196	5	the	the	DT
cord-310268-8q4tk6fd	196	6	small	small	JJ
cord-310268-8q4tk6fd	196	7	size	size	NN
cord-310268-8q4tk6fd	196	8	of	of	IN
cord-310268-8q4tk6fd	196	9	the	the	DT
cord-310268-8q4tk6fd	196	10	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	196	11	,	,	,
cord-310268-8q4tk6fd	196	12	the	the	DT
cord-310268-8q4tk6fd	196	13	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	196	14	sandwich	sandwich	NN
cord-310268-8q4tk6fd	196	15	mode	mode	NN
cord-310268-8q4tk6fd	196	16	can	can	MD
cord-310268-8q4tk6fd	196	17	conquer	conquer	VB
cord-310268-8q4tk6fd	196	18	the	the	DT
cord-310268-8q4tk6fd	196	19	potential	potential	JJ
cord-310268-8q4tk6fd	196	20	limitation	limitation	NN
cord-310268-8q4tk6fd	196	21	of	of	IN
cord-310268-8q4tk6fd	196	22	antibody	antibody	NN
cord-310268-8q4tk6fd	196	23	ELISA	ELISA	NNP
cord-310268-8q4tk6fd	196	24	in	in	IN
cord-310268-8q4tk6fd	196	25	detecting	detect	VBG
cord-310268-8q4tk6fd	196	26	small	small	JJ
cord-310268-8q4tk6fd	196	27	molecules	molecule	NNS
cord-310268-8q4tk6fd	196	28	[	[	-LRB-
cord-310268-8q4tk6fd	196	29	89	89	CD
cord-310268-8q4tk6fd	196	30	]	]	-RRB-
cord-310268-8q4tk6fd	196	31	.	.	.
cord-310268-8q4tk6fd	197	1	But	but	CC
cord-310268-8q4tk6fd	197	2	this	this	DT
cord-310268-8q4tk6fd	197	3	mode	mode	NN
cord-310268-8q4tk6fd	197	4	requires	require	VBZ
cord-310268-8q4tk6fd	197	5	extensive	extensive	JJ
cord-310268-8q4tk6fd	197	6	washing	washing	NN
cord-310268-8q4tk6fd	197	7	during	during	IN
cord-310268-8q4tk6fd	197	8	the	the	DT
cord-310268-8q4tk6fd	197	9	detection	detection	NN
cord-310268-8q4tk6fd	197	10	.	.	.
cord-310268-8q4tk6fd	198	1	In	in	IN
cord-310268-8q4tk6fd	198	2	the	the	DT
cord-310268-8q4tk6fd	198	3	target	target	NN
cord-310268-8q4tk6fd	198	4	-	-	HYPH
cord-310268-8q4tk6fd	198	5	induced	induce	VBN
cord-310268-8q4tk6fd	198	6	assembly	assembly	NN
cord-310268-8q4tk6fd	198	7	or	or	CC
cord-310268-8q4tk6fd	198	8	dissociation	dissociation	NN
cord-310268-8q4tk6fd	198	9	mode	mode	NN
cord-310268-8q4tk6fd	198	10	,	,	,
cord-310268-8q4tk6fd	198	11	binding	bind	VBG
cord-310268-8q4tk6fd	198	12	of	of	IN
cord-310268-8q4tk6fd	198	13	the	the	DT
cord-310268-8q4tk6fd	198	14	target	target	NN
cord-310268-8q4tk6fd	198	15	to	to	IN
cord-310268-8q4tk6fd	198	16	the	the	DT
cord-310268-8q4tk6fd	198	17	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	198	18	will	will	MD
cord-310268-8q4tk6fd	198	19	trigger	trigger	VB
cord-310268-8q4tk6fd	198	20	the	the	DT
cord-310268-8q4tk6fd	198	21	assembly	assembly	NN
cord-310268-8q4tk6fd	198	22	of	of	IN
cord-310268-8q4tk6fd	198	23	split	split	JJ
cord-310268-8q4tk6fd	198	24	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	198	25	or	or	CC
cord-310268-8q4tk6fd	198	26	dissociation	dissociation	NN
cord-310268-8q4tk6fd	198	27	of	of	IN
cord-310268-8q4tk6fd	198	28	bound	bind	VBN
cord-310268-8q4tk6fd	198	29	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	198	30	,	,	,
cord-310268-8q4tk6fd	198	31	along	along	IN
cord-310268-8q4tk6fd	198	32	with	with	IN
cord-310268-8q4tk6fd	198	33	the	the	DT
cord-310268-8q4tk6fd	198	34	change	change	NN
cord-310268-8q4tk6fd	198	35	of	of	IN
cord-310268-8q4tk6fd	198	36	detectable	detectable	JJ
cord-310268-8q4tk6fd	198	37	signals	signal	NNS
cord-310268-8q4tk6fd	198	38	[	[	-LRB-
cord-310268-8q4tk6fd	198	39	82	82	CD
cord-310268-8q4tk6fd	198	40	,	,	,
cord-310268-8q4tk6fd	198	41	90	90	CD
cord-310268-8q4tk6fd	198	42	]	]	-RRB-
cord-310268-8q4tk6fd	198	43	(	(	-LRB-
cord-310268-8q4tk6fd	198	44	Figure	figure	NN
cord-310268-8q4tk6fd	198	45	2D	2d	NN
cord-310268-8q4tk6fd	198	46	)	)	-RRB-
cord-310268-8q4tk6fd	198	47	.	.	.
cord-310268-8q4tk6fd	199	1	In	in	IN
cord-310268-8q4tk6fd	199	2	addition	addition	NN
cord-310268-8q4tk6fd	199	3	,	,	,
cord-310268-8q4tk6fd	199	4	it	-PRON-	PRP
cord-310268-8q4tk6fd	199	5	should	should	MD
cord-310268-8q4tk6fd	199	6	be	be	VB
cord-310268-8q4tk6fd	199	7	noted	note	VBN
cord-310268-8q4tk6fd	199	8	that	that	IN
cord-310268-8q4tk6fd	199	9	various	various	JJ
cord-310268-8q4tk6fd	199	10	detection	detection	NN
cord-310268-8q4tk6fd	199	11	methods	method	NNS
cord-310268-8q4tk6fd	199	12	have	have	VBP
cord-310268-8q4tk6fd	199	13	been	be	VBN
cord-310268-8q4tk6fd	199	14	applied	apply	VBN
cord-310268-8q4tk6fd	199	15	by	by	IN
cord-310268-8q4tk6fd	199	16	DNA	DNA	NNP
cord-310268-8q4tk6fd	199	17	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	199	18	based	base	VBN
cord-310268-8q4tk6fd	199	19	biosensors	biosensor	NNS
cord-310268-8q4tk6fd	199	20	,	,	,
cord-310268-8q4tk6fd	199	21	including	include	VBG
cord-310268-8q4tk6fd	199	22	electrochemical	electrochemical	JJ
cord-310268-8q4tk6fd	199	23	,	,	,
cord-310268-8q4tk6fd	199	24	chemiluminescence	chemiluminescence	NN
cord-310268-8q4tk6fd	199	25	,	,	,
cord-310268-8q4tk6fd	199	26	fluorescence	fluorescence	NN
cord-310268-8q4tk6fd	199	27	,	,	,
cord-310268-8q4tk6fd	199	28	colorimetric	colorimetric	JJ
cord-310268-8q4tk6fd	199	29	,	,	,
cord-310268-8q4tk6fd	199	30	quantum	quantum	JJ
cord-310268-8q4tk6fd	199	31	dots	dot	NNS
cord-310268-8q4tk6fd	199	32	-	-	HYPH
cord-310268-8q4tk6fd	199	33	based	base	VBN
cord-310268-8q4tk6fd	199	34	and	and	CC
cord-310268-8q4tk6fd	199	35	mass	mass	JJ
cord-310268-8q4tk6fd	199	36	-	-	HYPH
cord-310268-8q4tk6fd	199	37	sensitive	sensitive	JJ
cord-310268-8q4tk6fd	199	38	detections	detection	NNS
cord-310268-8q4tk6fd	199	39	[	[	-LRB-
cord-310268-8q4tk6fd	199	40	84	84	CD
cord-310268-8q4tk6fd	199	41	]	]	-RRB-
cord-310268-8q4tk6fd	199	42	.	.	.
cord-310268-8q4tk6fd	200	1	For	for	IN
cord-310268-8q4tk6fd	200	2	imaging	imaging	NN
cord-310268-8q4tk6fd	200	3	of	of	IN
cord-310268-8q4tk6fd	200	4	cancer	cancer	NN
cord-310268-8q4tk6fd	200	5	cells	cell	NNS
cord-310268-8q4tk6fd	200	6	,	,	,
cord-310268-8q4tk6fd	200	7	most	most	JJS
cord-310268-8q4tk6fd	200	8	of	of	IN
cord-310268-8q4tk6fd	200	9	the	the	DT
cord-310268-8q4tk6fd	200	10	DNA	DNA	NNP
cord-310268-8q4tk6fd	200	11	aptamer	aptamer	NN
cord-310268-8q4tk6fd	200	12	based	base	VBN
cord-310268-8q4tk6fd	200	13	methods	method	NNS
cord-310268-8q4tk6fd	200	14	use	use	VBP
cord-310268-8q4tk6fd	200	15	fluorophore	fluorophore	RB
cord-310268-8q4tk6fd	200	16	-	-	HYPH
cord-310268-8q4tk6fd	200	17	labeled	label	VBN
cord-310268-8q4tk6fd	200	18	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	200	19	to	to	TO
cord-310268-8q4tk6fd	200	20	recognize	recognize	VB
cord-310268-8q4tk6fd	200	21	the	the	DT
cord-310268-8q4tk6fd	200	22	cancer	cancer	NN
cord-310268-8q4tk6fd	200	23	cells	cell	NNS
cord-310268-8q4tk6fd	200	24	directly	directly	RB
cord-310268-8q4tk6fd	200	25	(	(	-LRB-
cord-310268-8q4tk6fd	200	26	Table	table	NN
cord-310268-8q4tk6fd	200	27	1	1	CD
cord-310268-8q4tk6fd	200	28	)	)	-RRB-
cord-310268-8q4tk6fd	200	29	.	.	.
cord-310268-8q4tk6fd	201	1	For	for	IN
cord-310268-8q4tk6fd	201	2	the	the	DT
cord-310268-8q4tk6fd	201	3	small	small	JJ
cord-310268-8q4tk6fd	201	4	targets	target	NNS
cord-310268-8q4tk6fd	201	5	like	like	IN
cord-310268-8q4tk6fd	201	6	microorganisms	microorganism	NNS
cord-310268-8q4tk6fd	201	7	and	and	CC
cord-310268-8q4tk6fd	201	8	the	the	DT
cord-310268-8q4tk6fd	201	9	marker	marker	NN
cord-310268-8q4tk6fd	201	10	protein	protein	NN
cord-310268-8q4tk6fd	201	11	,	,	,
cord-310268-8q4tk6fd	201	12	methods	method	NNS
cord-310268-8q4tk6fd	201	13	based	base	VBN
cord-310268-8q4tk6fd	201	14	on	on	IN
cord-310268-8q4tk6fd	201	15	different	different	JJ
cord-310268-8q4tk6fd	201	16	modes	mode	NNS
cord-310268-8q4tk6fd	201	17	have	have	VBP
cord-310268-8q4tk6fd	201	18	been	be	VBN
cord-310268-8q4tk6fd	201	19	explored	explore	VBN
cord-310268-8q4tk6fd	201	20	extensively	extensively	RB
cord-310268-8q4tk6fd	201	21	.	.	.
cord-310268-8q4tk6fd	202	1	The	the	DT
cord-310268-8q4tk6fd	202	2	sandwich	sandwich	NN
cord-310268-8q4tk6fd	202	3	-	-	HYPH
cord-310268-8q4tk6fd	202	4	like	like	JJ
cord-310268-8q4tk6fd	202	5	mode	mode	NN
cord-310268-8q4tk6fd	202	6	is	be	VBZ
cord-310268-8q4tk6fd	202	7	frequently	frequently	RB
cord-310268-8q4tk6fd	202	8	used	use	VBN
cord-310268-8q4tk6fd	202	9	(	(	-LRB-
cord-310268-8q4tk6fd	202	10	Figure	figure	NN
cord-310268-8q4tk6fd	202	11	2C	2c	NN
cord-310268-8q4tk6fd	202	12	)	)	-RRB-
cord-310268-8q4tk6fd	202	13	[	[	-LRB-
cord-310268-8q4tk6fd	202	14	68	68	CD
cord-310268-8q4tk6fd	202	15	,	,	,
cord-310268-8q4tk6fd	202	16	91	91	CD
cord-310268-8q4tk6fd	202	17	]	]	-RRB-
cord-310268-8q4tk6fd	202	18	.	.	.
cord-310268-8q4tk6fd	203	1	In	in	IN
cord-310268-8q4tk6fd	203	2	the	the	DT
cord-310268-8q4tk6fd	203	3	example	example	NN
cord-310268-8q4tk6fd	203	4	of	of	IN
cord-310268-8q4tk6fd	203	5	Leishmania	Leishmania	NNP
cord-310268-8q4tk6fd	203	6	detection	detection	NN
cord-310268-8q4tk6fd	203	7	[	[	-LRB-
cord-310268-8q4tk6fd	203	8	68	68	CD
cord-310268-8q4tk6fd	203	9	]	]	-RRB-
cord-310268-8q4tk6fd	203	10	,	,	,
cord-310268-8q4tk6fd	203	11	the	the	DT
cord-310268-8q4tk6fd	203	12	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	203	13	(	(	-LRB-
cord-310268-8q4tk6fd	203	14	LmWC-25R	lmwc-25r	NN
cord-310268-8q4tk6fd	203	15	)	)	-RRB-
cord-310268-8q4tk6fd	203	16	targeting	target	VBG
cord-310268-8q4tk6fd	203	17	the	the	DT
cord-310268-8q4tk6fd	203	18	promastigote	promastigote	NN
cord-310268-8q4tk6fd	203	19	of	of	IN
cord-310268-8q4tk6fd	203	20	Leishmania	Leishmania	NNP
cord-310268-8q4tk6fd	203	21	was	be	VBD
cord-310268-8q4tk6fd	203	22	immobilized	immobilize	VBN
cord-310268-8q4tk6fd	203	23	on	on	IN
cord-310268-8q4tk6fd	203	24	the	the	DT
cord-310268-8q4tk6fd	203	25	surface	surface	NN
cord-310268-8q4tk6fd	203	26	of	of	IN
cord-310268-8q4tk6fd	203	27	the	the	DT
cord-310268-8q4tk6fd	203	28	M280	M280	NNP
cord-310268-8q4tk6fd	203	29	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	203	30	beads	bead	NNS
cord-310268-8q4tk6fd	203	31	.	.	.
cord-310268-8q4tk6fd	204	1	After	after	IN
cord-310268-8q4tk6fd	204	2	the	the	DT
cord-310268-8q4tk6fd	204	3	target	target	NN
cord-310268-8q4tk6fd	204	4	Leishmania	Leishmania	NNP
cord-310268-8q4tk6fd	204	5	promastigote	promastigote	NN
cord-310268-8q4tk6fd	204	6	were	be	VBD
cord-310268-8q4tk6fd	204	7	captured	capture	VBN
cord-310268-8q4tk6fd	204	8	by	by	IN
cord-310268-8q4tk6fd	204	9	LmWC-25R	lmwc-25r	NN
cord-310268-8q4tk6fd	204	10	,	,	,
cord-310268-8q4tk6fd	205	1	another	another	DT
cord-310268-8q4tk6fd	205	2	5	5	CD
cord-310268-8q4tk6fd	205	3	1	1	CD
cord-310268-8q4tk6fd	205	4	-biotinylated	-biotinylated	JJ
cord-310268-8q4tk6fd	205	5	reporter	reporter	NN
cord-310268-8q4tk6fd	205	6	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	205	7	(	(	-LRB-
cord-310268-8q4tk6fd	205	8	LmHSP-7b/11R	lmhsp-7b/11r	UH
cord-310268-8q4tk6fd	205	9	)	)	-RRB-
cord-310268-8q4tk6fd	205	10	that	that	WDT
cord-310268-8q4tk6fd	205	11	targets	target	VBZ
cord-310268-8q4tk6fd	205	12	the	the	DT
cord-310268-8q4tk6fd	205	13	hydrophilic	hydrophilic	JJ
cord-310268-8q4tk6fd	205	14	surface	surface	NN
cord-310268-8q4tk6fd	205	15	protein	protein	NN
cord-310268-8q4tk6fd	205	16	(	(	-LRB-
cord-310268-8q4tk6fd	205	17	HSP	HSP	NNP
cord-310268-8q4tk6fd	205	18	)	)	-RRB-
cord-310268-8q4tk6fd	205	19	of	of	IN
cord-310268-8q4tk6fd	205	20	Leishmania	Leishmania	NNP
cord-310268-8q4tk6fd	205	21	promastigote	promastigote	NNP
cord-310268-8q4tk6fd	205	22	was	be	VBD
cord-310268-8q4tk6fd	205	23	added	add	VBN
cord-310268-8q4tk6fd	205	24	.	.	.
cord-310268-8q4tk6fd	206	1	Then	then	RB
cord-310268-8q4tk6fd	206	2	the	the	DT
cord-310268-8q4tk6fd	206	3	beads	bead	NNS
cord-310268-8q4tk6fd	206	4	with	with	IN
cord-310268-8q4tk6fd	206	5	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	206	6	-	-	HYPH
cord-310268-8q4tk6fd	206	7	captured	capture	VBN
cord-310268-8q4tk6fd	206	8	Leishmania	Leishmania	NNP
cord-310268-8q4tk6fd	206	9	promastigote	promastigote	NN
cord-310268-8q4tk6fd	206	10	and	and	CC
cord-310268-8q4tk6fd	206	11	reporters	reporter	NNS
cord-310268-8q4tk6fd	206	12	were	be	VBD
cord-310268-8q4tk6fd	206	13	collected	collect	VBN
cord-310268-8q4tk6fd	206	14	on	on	IN
cord-310268-8q4tk6fd	206	15	the	the	DT
cord-310268-8q4tk6fd	206	16	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	206	17	rack	rack	NN
cord-310268-8q4tk6fd	206	18	.	.	.
cord-310268-8q4tk6fd	207	1	Streptavidin	streptavidin	NN
cord-310268-8q4tk6fd	207	2	-	-	HYPH
cord-310268-8q4tk6fd	207	3	horseradish	horseradish	NN
cord-310268-8q4tk6fd	207	4	peroxidase	peroxidase	NN
cord-310268-8q4tk6fd	207	5	(	(	-LRB-
cord-310268-8q4tk6fd	207	6	Sav	Sav	NNP
cord-310268-8q4tk6fd	207	7	-	-	HYPH
cord-310268-8q4tk6fd	207	8	HRP	HRP	NNP
cord-310268-8q4tk6fd	207	9	)	)	-RRB-
cord-310268-8q4tk6fd	207	10	and	and	CC
cord-310268-8q4tk6fd	207	11	the	the	DT
cord-310268-8q4tk6fd	207	12	substrate	substrate	JJ
cord-310268-8q4tk6fd	207	13	Ample	Ample	NNP
cord-310268-8q4tk6fd	207	14	Red	Red	NNP
cord-310268-8q4tk6fd	207	15	were	be	VBD
cord-310268-8q4tk6fd	207	16	added	add	VBN
cord-310268-8q4tk6fd	207	17	to	to	TO
cord-310268-8q4tk6fd	207	18	transduce	transduce	VB
cord-310268-8q4tk6fd	207	19	and	and	CC
cord-310268-8q4tk6fd	207	20	display	display	VB
cord-310268-8q4tk6fd	207	21	the	the	DT
cord-310268-8q4tk6fd	207	22	signal	signal	NN
cord-310268-8q4tk6fd	207	23	.	.	.
cord-310268-8q4tk6fd	208	1	Another	another	DT
cord-310268-8q4tk6fd	208	2	frequently	frequently	RB
cord-310268-8q4tk6fd	208	3	used	use	VBN
cord-310268-8q4tk6fd	208	4	mode	mode	NN
cord-310268-8q4tk6fd	208	5	is	be	VBZ
cord-310268-8q4tk6fd	208	6	the	the	DT
cord-310268-8q4tk6fd	208	7	target	target	NN
cord-310268-8q4tk6fd	208	8	-	-	HYPH
cord-310268-8q4tk6fd	208	9	induced	induce	VBN
cord-310268-8q4tk6fd	208	10	dissociation	dissociation	NN
cord-310268-8q4tk6fd	208	11	mode	mode	NN
cord-310268-8q4tk6fd	208	12	,	,	,
cord-310268-8q4tk6fd	208	13	in	in	IN
cord-310268-8q4tk6fd	208	14	which	which	WDT
cord-310268-8q4tk6fd	208	15	the	the	DT
cord-310268-8q4tk6fd	208	16	system	system	NN
cord-310268-8q4tk6fd	208	17	was	be	VBD
cord-310268-8q4tk6fd	208	18	in	in	IN
cord-310268-8q4tk6fd	208	19	a	a	DT
cord-310268-8q4tk6fd	208	20	non	non	JJ
cord-310268-8q4tk6fd	208	21	-	-	JJ
cord-310268-8q4tk6fd	208	22	signal	signal	JJ
cord-310268-8q4tk6fd	208	23	status	status	NN
cord-310268-8q4tk6fd	208	24	until	until	IN
cord-310268-8q4tk6fd	208	25	the	the	DT
cord-310268-8q4tk6fd	208	26	single	single	RB
cord-310268-8q4tk6fd	208	27	-	-	HYPH
cord-310268-8q4tk6fd	208	28	stranded	strand	VBN
cord-310268-8q4tk6fd	208	29	aptamer	aptamer	NN
cord-310268-8q4tk6fd	208	30	dissociated	dissociate	VBN
cord-310268-8q4tk6fd	208	31	from	from	IN
cord-310268-8q4tk6fd	208	32	the	the	DT
cord-310268-8q4tk6fd	208	33	initial	initial	JJ
cord-310268-8q4tk6fd	208	34	state	state	NN
cord-310268-8q4tk6fd	208	35	as	as	IN
cord-310268-8q4tk6fd	208	36	a	a	DT
cord-310268-8q4tk6fd	208	37	result	result	NN
cord-310268-8q4tk6fd	208	38	of	of	IN
cord-310268-8q4tk6fd	208	39	binding	bind	VBG
cord-310268-8q4tk6fd	208	40	to	to	IN
cord-310268-8q4tk6fd	208	41	the	the	DT
cord-310268-8q4tk6fd	208	42	target	target	NN
cord-310268-8q4tk6fd	208	43	[	[	-LRB-
cord-310268-8q4tk6fd	208	44	69	69	CD
cord-310268-8q4tk6fd	208	45	,	,	,
cord-310268-8q4tk6fd	208	46	72	72	CD
cord-310268-8q4tk6fd	208	47	,	,	,
cord-310268-8q4tk6fd	208	48	73	73	CD
cord-310268-8q4tk6fd	208	49	]	]	-RRB-
cord-310268-8q4tk6fd	208	50	.	.	.
cord-310268-8q4tk6fd	209	1	The	the	DT
cord-310268-8q4tk6fd	209	2	detection	detection	NN
cord-310268-8q4tk6fd	209	3	of	of	IN
cord-310268-8q4tk6fd	209	4	L	l	NN
cord-310268-8q4tk6fd	209	5	-	-	HYPH
cord-310268-8q4tk6fd	209	6	homocysteine	homocysteine	NN
cord-310268-8q4tk6fd	209	7	mentioned	mention	VBN
cord-310268-8q4tk6fd	209	8	above	above	RB
cord-310268-8q4tk6fd	209	9	is	be	VBZ
cord-310268-8q4tk6fd	209	10	a	a	DT
cord-310268-8q4tk6fd	209	11	good	good	JJ
cord-310268-8q4tk6fd	209	12	example	example	NN
cord-310268-8q4tk6fd	209	13	of	of	IN
cord-310268-8q4tk6fd	209	14	the	the	DT
cord-310268-8q4tk6fd	209	15	target	target	NN
cord-310268-8q4tk6fd	209	16	-	-	HYPH
cord-310268-8q4tk6fd	209	17	induced	induce	VBN
cord-310268-8q4tk6fd	209	18	dissociation	dissociation	NN
cord-310268-8q4tk6fd	209	19	mode	mode	NN
cord-310268-8q4tk6fd	209	20	[	[	-LRB-
cord-310268-8q4tk6fd	209	21	73	73	CD
cord-310268-8q4tk6fd	209	22	]	]	-RRB-
cord-310268-8q4tk6fd	210	1	(	(	-LRB-
cord-310268-8q4tk6fd	210	2	Figure	Figure	NNP
cord-310268-8q4tk6fd	210	3	2D	2d	NN
cord-310268-8q4tk6fd	210	4	)	)	-RRB-
cord-310268-8q4tk6fd	210	5	.	.	.
cord-310268-8q4tk6fd	211	1	DNA	DNA	NNP
cord-310268-8q4tk6fd	211	2	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	211	3	coil	coil	NN
cord-310268-8q4tk6fd	211	4	around	around	IN
cord-310268-8q4tk6fd	211	5	the	the	DT
cord-310268-8q4tk6fd	211	6	surface	surface	NN
cord-310268-8q4tk6fd	211	7	of	of	IN
cord-310268-8q4tk6fd	211	8	the	the	DT
cord-310268-8q4tk6fd	211	9	gold	gold	NN
cord-310268-8q4tk6fd	211	10	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	211	11	(	(	-LRB-
cord-310268-8q4tk6fd	211	12	AuNPs	AuNPs	JJS
cord-310268-8q4tk6fd	211	13	)	)	-RRB-
cord-310268-8q4tk6fd	211	14	and	and	CC
cord-310268-8q4tk6fd	211	15	prevent	prevent	VB
cord-310268-8q4tk6fd	211	16	the	the	DT
cord-310268-8q4tk6fd	211	17	salt	salt	NN
cord-310268-8q4tk6fd	211	18	-	-	HYPH
cord-310268-8q4tk6fd	211	19	induced	induce	VBN
cord-310268-8q4tk6fd	211	20	aggregation	aggregation	NN
cord-310268-8q4tk6fd	211	21	of	of	IN
cord-310268-8q4tk6fd	211	22	AuNPs	AuNPs	NNP
cord-310268-8q4tk6fd	211	23	.	.	.
cord-310268-8q4tk6fd	212	1	When	when	WRB
cord-310268-8q4tk6fd	212	2	the	the	DT
cord-310268-8q4tk6fd	212	3	target	target	NN
cord-310268-8q4tk6fd	212	4	molecules	molecule	NNS
cord-310268-8q4tk6fd	212	5	appear	appear	VBP
cord-310268-8q4tk6fd	212	6	,	,	,
cord-310268-8q4tk6fd	212	7	the	the	DT
cord-310268-8q4tk6fd	212	8	DNA	dna	NN
cord-310268-8q4tk6fd	212	9	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	212	10	fold	fold	VBP
cord-310268-8q4tk6fd	212	11	into	into	IN
cord-310268-8q4tk6fd	212	12	a	a	DT
cord-310268-8q4tk6fd	212	13	rigid	rigid	JJ
cord-310268-8q4tk6fd	212	14	structure	structure	NN
cord-310268-8q4tk6fd	212	15	and	and	CC
cord-310268-8q4tk6fd	212	16	bind	bind	VB
cord-310268-8q4tk6fd	212	17	to	to	IN
cord-310268-8q4tk6fd	212	18	the	the	DT
cord-310268-8q4tk6fd	212	19	targets	target	NNS
cord-310268-8q4tk6fd	212	20	,	,	,
cord-310268-8q4tk6fd	212	21	and	and	CC
cord-310268-8q4tk6fd	212	22	therefore	therefore	RB
cord-310268-8q4tk6fd	212	23	release	release	VBP
cord-310268-8q4tk6fd	212	24	from	from	IN
cord-310268-8q4tk6fd	212	25	the	the	DT
cord-310268-8q4tk6fd	212	26	AuNPs	AuNPs	NNP
cord-310268-8q4tk6fd	212	27	.	.	.
cord-310268-8q4tk6fd	213	1	The	the	DT
cord-310268-8q4tk6fd	213	2	AuNPs	AuNPs	NNP
cord-310268-8q4tk6fd	213	3	without	without	IN
cord-310268-8q4tk6fd	213	4	the	the	DT
cord-310268-8q4tk6fd	213	5	coverage	coverage	NN
cord-310268-8q4tk6fd	213	6	of	of	IN
cord-310268-8q4tk6fd	213	7	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	213	8	aggregate	aggregate	VBP
cord-310268-8q4tk6fd	213	9	in	in	IN
cord-310268-8q4tk6fd	213	10	the	the	DT
cord-310268-8q4tk6fd	213	11	salt	salt	NN
cord-310268-8q4tk6fd	213	12	solution	solution	NN
cord-310268-8q4tk6fd	213	13	and	and	CC
cord-310268-8q4tk6fd	213	14	change	change	VB
cord-310268-8q4tk6fd	213	15	color	color	NN
cord-310268-8q4tk6fd	213	16	from	from	IN
cord-310268-8q4tk6fd	213	17	red	red	JJ
cord-310268-8q4tk6fd	213	18	to	to	IN
cord-310268-8q4tk6fd	213	19	purple	purple	NN
cord-310268-8q4tk6fd	213	20	.	.	.
cord-310268-8q4tk6fd	214	1	The	the	DT
cord-310268-8q4tk6fd	214	2	signal	signal	NN
cord-310268-8q4tk6fd	214	3	-	-	HYPH
cord-310268-8q4tk6fd	214	4	molecule	molecule	NN
cord-310268-8q4tk6fd	214	5	-	-	HYPH
cord-310268-8q4tk6fd	214	6	labeled	label	VBN
cord-310268-8q4tk6fd	214	7	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	214	8	directly	directly	RB
cord-310268-8q4tk6fd	214	9	bind	bind	VB
cord-310268-8q4tk6fd	214	10	to	to	IN
cord-310268-8q4tk6fd	214	11	the	the	DT
cord-310268-8q4tk6fd	214	12	immobilized	immobilized	JJ
cord-310268-8q4tk6fd	214	13	or	or	CC
cord-310268-8q4tk6fd	214	14	free	free	JJ
cord-310268-8q4tk6fd	214	15	target	target	NN
cord-310268-8q4tk6fd	214	16	.	.	.
cord-310268-8q4tk6fd	215	1	The	the	DT
cord-310268-8q4tk6fd	215	2	signal	signal	NN
cord-310268-8q4tk6fd	215	3	molecules	molecule	NNS
cord-310268-8q4tk6fd	215	4	on	on	IN
cord-310268-8q4tk6fd	215	5	the	the	DT
cord-310268-8q4tk6fd	215	6	target	target	NN
cord-310268-8q4tk6fd	215	7	are	be	VBP
cord-310268-8q4tk6fd	215	8	detected	detect	VBN
cord-310268-8q4tk6fd	215	9	directly	directly	RB
cord-310268-8q4tk6fd	215	10	;	;	:
cord-310268-8q4tk6fd	215	11	(	(	-LRB-
cord-310268-8q4tk6fd	215	12	B	b	NN
cord-310268-8q4tk6fd	215	13	)	)	-RRB-
cord-310268-8q4tk6fd	215	14	Target	target	NN
cord-310268-8q4tk6fd	215	15	-	-	HYPH
cord-310268-8q4tk6fd	215	16	induced	induce	VBN
cord-310268-8q4tk6fd	215	17	structural	structural	JJ
cord-310268-8q4tk6fd	215	18	switching	switching	NN
cord-310268-8q4tk6fd	215	19	mode	mode	NN
cord-310268-8q4tk6fd	215	20	:	:	:
cord-310268-8q4tk6fd	215	21	A	a	DT
cord-310268-8q4tk6fd	215	22	fluorophore	fluorophore	RB
cord-310268-8q4tk6fd	215	23	-	-	HYPH
cord-310268-8q4tk6fd	215	24	labeled	label	VBN
cord-310268-8q4tk6fd	215	25	DNA	DNA	NNP
cord-310268-8q4tk6fd	215	26	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	215	27	forms	form	VBZ
cord-310268-8q4tk6fd	215	28	a	a	DT
cord-310268-8q4tk6fd	215	29	partial	partial	JJ
cord-310268-8q4tk6fd	215	30	duplex	duplex	NN
cord-310268-8q4tk6fd	215	31	with	with	IN
cord-310268-8q4tk6fd	215	32	a	a	DT
cord-310268-8q4tk6fd	215	33	small	small	JJ
cord-310268-8q4tk6fd	215	34	oligonucleotide	oligonucleotide	NN
cord-310268-8q4tk6fd	215	35	modified	modify	VBN
cord-310268-8q4tk6fd	215	36	with	with	IN
cord-310268-8q4tk6fd	215	37	a	a	DT
cord-310268-8q4tk6fd	215	38	quenching	quenching	NN
cord-310268-8q4tk6fd	215	39	moiety	moiety	NN
cord-310268-8q4tk6fd	215	40	(	(	-LRB-
cord-310268-8q4tk6fd	215	41	QDNA	QDNA	NNP
cord-310268-8q4tk6fd	215	42	)	)	-RRB-
cord-310268-8q4tk6fd	215	43	in	in	IN
cord-310268-8q4tk6fd	215	44	the	the	DT
cord-310268-8q4tk6fd	215	45	absence	absence	NN
cord-310268-8q4tk6fd	215	46	of	of	IN
cord-310268-8q4tk6fd	215	47	the	the	DT
cord-310268-8q4tk6fd	215	48	target	target	NN
cord-310268-8q4tk6fd	215	49	,	,	,
cord-310268-8q4tk6fd	215	50	bringing	bring	VBG
cord-310268-8q4tk6fd	215	51	the	the	DT
cord-310268-8q4tk6fd	215	52	fluorophore	fluorophore	NN
cord-310268-8q4tk6fd	215	53	(	(	-LRB-
cord-310268-8q4tk6fd	215	54	F	F	NNP
cord-310268-8q4tk6fd	215	55	)	)	-RRB-
cord-310268-8q4tk6fd	215	56	and	and	CC
cord-310268-8q4tk6fd	215	57	the	the	DT
cord-310268-8q4tk6fd	215	58	quencher	quencher	NN
cord-310268-8q4tk6fd	215	59	(	(	-LRB-
cord-310268-8q4tk6fd	215	60	Q	Q	NNP
cord-310268-8q4tk6fd	215	61	)	)	-RRB-
cord-310268-8q4tk6fd	215	62	into	into	IN
cord-310268-8q4tk6fd	215	63	close	close	JJ
cord-310268-8q4tk6fd	215	64	proximity	proximity	NN
cord-310268-8q4tk6fd	215	65	for	for	IN
cord-310268-8q4tk6fd	215	66	maximum	maximum	JJ
cord-310268-8q4tk6fd	215	67	fluorescence	fluorescence	NN
cord-310268-8q4tk6fd	215	68	quenching	quenching	NN
cord-310268-8q4tk6fd	215	69	.	.	.
cord-310268-8q4tk6fd	216	1	When	when	WRB
cord-310268-8q4tk6fd	216	2	the	the	DT
cord-310268-8q4tk6fd	216	3	target	target	NN
cord-310268-8q4tk6fd	216	4	is	be	VBZ
cord-310268-8q4tk6fd	216	5	introduced	introduce	VBN
cord-310268-8q4tk6fd	216	6	,	,	,
cord-310268-8q4tk6fd	216	7	the	the	DT
cord-310268-8q4tk6fd	216	8	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	216	9	prefers	prefer	VBZ
cord-310268-8q4tk6fd	216	10	to	to	TO
cord-310268-8q4tk6fd	216	11	form	form	VB
cord-310268-8q4tk6fd	216	12	the	the	DT
cord-310268-8q4tk6fd	216	13	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	216	14	-	-	HYPH
cord-310268-8q4tk6fd	216	15	target	target	NN
cord-310268-8q4tk6fd	216	16	complex	complex	NN
cord-310268-8q4tk6fd	216	17	.	.	.
cord-310268-8q4tk6fd	217	1	The	the	DT
cord-310268-8q4tk6fd	217	2	binding	binding	NN
cord-310268-8q4tk6fd	217	3	of	of	IN
cord-310268-8q4tk6fd	217	4	the	the	DT
cord-310268-8q4tk6fd	217	5	target	target	NN
cord-310268-8q4tk6fd	217	6	to	to	IN
cord-310268-8q4tk6fd	217	7	the	the	DT
cord-310268-8q4tk6fd	217	8	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	217	9	will	will	MD
cord-310268-8q4tk6fd	217	10	change	change	VB
cord-310268-8q4tk6fd	217	11	the	the	DT
cord-310268-8q4tk6fd	217	12	structure	structure	NN
cord-310268-8q4tk6fd	217	13	of	of	IN
cord-310268-8q4tk6fd	217	14	the	the	DT
cord-310268-8q4tk6fd	217	15	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	217	16	and	and	CC
cord-310268-8q4tk6fd	217	17	release	release	VB
cord-310268-8q4tk6fd	217	18	the	the	DT
cord-310268-8q4tk6fd	217	19	partially	partially	RB
cord-310268-8q4tk6fd	217	20	complementary	complementary	JJ
cord-310268-8q4tk6fd	217	21	quencher	quencher	NN
cord-310268-8q4tk6fd	217	22	,	,	,
cord-310268-8q4tk6fd	217	23	which	which	WDT
cord-310268-8q4tk6fd	217	24	will	will	MD
cord-310268-8q4tk6fd	217	25	trigger	trigger	VB
cord-310268-8q4tk6fd	217	26	the	the	DT
cord-310268-8q4tk6fd	217	27	increase	increase	NN
cord-310268-8q4tk6fd	217	28	of	of	IN
cord-310268-8q4tk6fd	217	29	the	the	DT
cord-310268-8q4tk6fd	217	30	signal	signal	NN
cord-310268-8q4tk6fd	217	31	;	;	:
cord-310268-8q4tk6fd	217	32	(	(	-LRB-
cord-310268-8q4tk6fd	217	33	C	C	NNP
cord-310268-8q4tk6fd	217	34	)	)	-RRB-
cord-310268-8q4tk6fd	217	35	Sandwich	sandwich	NN
cord-310268-8q4tk6fd	217	36	-	-	HYPH
cord-310268-8q4tk6fd	217	37	like	like	JJ
cord-310268-8q4tk6fd	217	38	mode	mode	NN
cord-310268-8q4tk6fd	217	39	:	:	:
cord-310268-8q4tk6fd	217	40	The	the	DT
cord-310268-8q4tk6fd	217	41	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	217	42	or	or	CC
cord-310268-8q4tk6fd	217	43	antibody	antibody	NN
cord-310268-8q4tk6fd	217	44	is	be	VBZ
cord-310268-8q4tk6fd	217	45	immobilized	immobilize	VBN
cord-310268-8q4tk6fd	217	46	on	on	IN
cord-310268-8q4tk6fd	217	47	the	the	DT
cord-310268-8q4tk6fd	217	48	solid	solid	JJ
cord-310268-8q4tk6fd	217	49	phase	phase	NN
cord-310268-8q4tk6fd	217	50	as	as	IN
cord-310268-8q4tk6fd	217	51	the	the	DT
cord-310268-8q4tk6fd	217	52	capturer	capturer	NN
cord-310268-8q4tk6fd	217	53	.	.	.
cord-310268-8q4tk6fd	218	1	The	the	DT
cord-310268-8q4tk6fd	218	2	captured	capture	VBN
cord-310268-8q4tk6fd	218	3	target	target	NN
cord-310268-8q4tk6fd	218	4	is	be	VBZ
cord-310268-8q4tk6fd	218	5	reported	report	VBN
cord-310268-8q4tk6fd	218	6	by	by	IN
cord-310268-8q4tk6fd	218	7	the	the	DT
cord-310268-8q4tk6fd	218	8	biotinylated	biotinylated	JJ
cord-310268-8q4tk6fd	218	9	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	218	10	,	,	,
cord-310268-8q4tk6fd	218	11	which	which	WDT
cord-310268-8q4tk6fd	218	12	displays	display	VBZ
cord-310268-8q4tk6fd	218	13	the	the	DT
cord-310268-8q4tk6fd	218	14	signal	signal	NN
cord-310268-8q4tk6fd	218	15	through	through	IN
cord-310268-8q4tk6fd	218	16	further	further	JJ
cord-310268-8q4tk6fd	218	17	binding	bind	VBG
cord-310268-8q4tk6fd	218	18	to	to	IN
cord-310268-8q4tk6fd	218	19	the	the	DT
cord-310268-8q4tk6fd	218	20	streptavidin	streptavidin	NN
cord-310268-8q4tk6fd	218	21	-	-	HYPH
cord-310268-8q4tk6fd	218	22	conjugated	conjugate	VBN
cord-310268-8q4tk6fd	218	23	HRP	HRP	NNP
cord-310268-8q4tk6fd	218	24	or	or	CC
cord-310268-8q4tk6fd	218	25	AuNP	aunp	NN
cord-310268-8q4tk6fd	218	26	;	;	:
cord-310268-8q4tk6fd	218	27	(	(	-LRB-
cord-310268-8q4tk6fd	218	28	D	D	NNP
cord-310268-8q4tk6fd	218	29	)	)	-RRB-
cord-310268-8q4tk6fd	218	30	Target	target	NN
cord-310268-8q4tk6fd	218	31	-	-	HYPH
cord-310268-8q4tk6fd	218	32	induced	induce	VBN
cord-310268-8q4tk6fd	218	33	dissociation	dissociation	NN
cord-310268-8q4tk6fd	218	34	mode	mode	NN
cord-310268-8q4tk6fd	218	35	:	:	:
cord-310268-8q4tk6fd	218	36	DNA	dna	NN
cord-310268-8q4tk6fd	218	37	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	218	38	coil	coil	NN
cord-310268-8q4tk6fd	218	39	around	around	IN
cord-310268-8q4tk6fd	218	40	the	the	DT
cord-310268-8q4tk6fd	218	41	surface	surface	NN
cord-310268-8q4tk6fd	218	42	of	of	IN
cord-310268-8q4tk6fd	218	43	the	the	DT
cord-310268-8q4tk6fd	218	44	gold	gold	NN
cord-310268-8q4tk6fd	218	45	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	218	46	(	(	-LRB-
cord-310268-8q4tk6fd	218	47	AuNPs	AuNPs	JJS
cord-310268-8q4tk6fd	218	48	)	)	-RRB-
cord-310268-8q4tk6fd	218	49	and	and	CC
cord-310268-8q4tk6fd	218	50	stop	stop	VB
cord-310268-8q4tk6fd	218	51	the	the	DT
cord-310268-8q4tk6fd	218	52	salt	salt	NN
cord-310268-8q4tk6fd	218	53	-	-	HYPH
cord-310268-8q4tk6fd	218	54	induced	induce	VBN
cord-310268-8q4tk6fd	218	55	aggregation	aggregation	NN
cord-310268-8q4tk6fd	218	56	of	of	IN
cord-310268-8q4tk6fd	218	57	AuNPs	AuNPs	NNP
cord-310268-8q4tk6fd	218	58	.	.	.
cord-310268-8q4tk6fd	219	1	When	when	WRB
cord-310268-8q4tk6fd	219	2	the	the	DT
cord-310268-8q4tk6fd	219	3	target	target	NN
cord-310268-8q4tk6fd	219	4	appears	appear	VBZ
cord-310268-8q4tk6fd	219	5	,	,	,
cord-310268-8q4tk6fd	219	6	the	the	DT
cord-310268-8q4tk6fd	219	7	DNA	dna	NN
cord-310268-8q4tk6fd	219	8	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	219	9	bind	bind	VBP
cord-310268-8q4tk6fd	219	10	to	to	IN
cord-310268-8q4tk6fd	219	11	the	the	DT
cord-310268-8q4tk6fd	219	12	target	target	NN
cord-310268-8q4tk6fd	219	13	and	and	CC
cord-310268-8q4tk6fd	219	14	release	release	NN
cord-310268-8q4tk6fd	219	15	from	from	IN
cord-310268-8q4tk6fd	219	16	the	the	DT
cord-310268-8q4tk6fd	219	17	AuNPs	AuNPs	NNP
cord-310268-8q4tk6fd	219	18	.	.	.
cord-310268-8q4tk6fd	220	1	The	the	DT
cord-310268-8q4tk6fd	220	2	AuNPs	AuNPs	NNP
cord-310268-8q4tk6fd	220	3	without	without	IN
cord-310268-8q4tk6fd	220	4	the	the	DT
cord-310268-8q4tk6fd	220	5	cover	cover	NN
cord-310268-8q4tk6fd	220	6	of	of	IN
cord-310268-8q4tk6fd	220	7	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	220	8	aggregate	aggregate	VBP
cord-310268-8q4tk6fd	220	9	in	in	IN
cord-310268-8q4tk6fd	220	10	the	the	DT
cord-310268-8q4tk6fd	220	11	salt	salt	NN
cord-310268-8q4tk6fd	220	12	solution	solution	NN
cord-310268-8q4tk6fd	220	13	and	and	CC
cord-310268-8q4tk6fd	220	14	change	change	VB
cord-310268-8q4tk6fd	220	15	color	color	NN
cord-310268-8q4tk6fd	220	16	from	from	IN
cord-310268-8q4tk6fd	220	17	red	red	JJ
cord-310268-8q4tk6fd	220	18	to	to	IN
cord-310268-8q4tk6fd	220	19	purple	purple	NN
cord-310268-8q4tk6fd	220	20	.	.	.
cord-310268-8q4tk6fd	221	1	One	one	CD
cord-310268-8q4tk6fd	221	2	of	of	IN
cord-310268-8q4tk6fd	221	3	the	the	DT
cord-310268-8q4tk6fd	221	4	biggest	big	JJS
cord-310268-8q4tk6fd	221	5	challenges	challenge	NNS
cord-310268-8q4tk6fd	221	6	for	for	IN
cord-310268-8q4tk6fd	221	7	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	221	8	-	-	HYPH
cord-310268-8q4tk6fd	221	9	based	base	VBN
cord-310268-8q4tk6fd	221	10	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	221	11	tools	tool	NNS
cord-310268-8q4tk6fd	221	12	and	and	CC
cord-310268-8q4tk6fd	221	13	their	-PRON-	PRP$
cord-310268-8q4tk6fd	221	14	clinical	clinical	JJ
cord-310268-8q4tk6fd	221	15	use	use	NN
cord-310268-8q4tk6fd	221	16	is	be	VBZ
cord-310268-8q4tk6fd	221	17	the	the	DT
cord-310268-8q4tk6fd	221	18	possible	possible	JJ
cord-310268-8q4tk6fd	221	19	invalidation	invalidation	NN
cord-310268-8q4tk6fd	221	20	in	in	IN
cord-310268-8q4tk6fd	221	21	a	a	DT
cord-310268-8q4tk6fd	221	22	real	real	JJ
cord-310268-8q4tk6fd	221	23	biological	biological	JJ
cord-310268-8q4tk6fd	221	24	environment	environment	NN
cord-310268-8q4tk6fd	221	25	as	as	IN
cord-310268-8q4tk6fd	221	26	a	a	DT
cord-310268-8q4tk6fd	221	27	result	result	NN
cord-310268-8q4tk6fd	221	28	of	of	IN
cord-310268-8q4tk6fd	221	29	degradation	degradation	NN
cord-310268-8q4tk6fd	221	30	from	from	IN
cord-310268-8q4tk6fd	221	31	nucleases	nuclease	NNS
cord-310268-8q4tk6fd	221	32	or	or	CC
cord-310268-8q4tk6fd	221	33	interference	interference	NN
cord-310268-8q4tk6fd	221	34	from	from	IN
cord-310268-8q4tk6fd	221	35	other	other	JJ
cord-310268-8q4tk6fd	221	36	matrix	matrix	NN
cord-310268-8q4tk6fd	221	37	factors	factor	NNS
cord-310268-8q4tk6fd	221	38	.	.	.
cord-310268-8q4tk6fd	222	1	Using	use	VBG
cord-310268-8q4tk6fd	222	2	chemical	chemical	NN
cord-310268-8q4tk6fd	222	3	modified	modify	VBN
cord-310268-8q4tk6fd	222	4	DNA	DNA	NNP
cord-310268-8q4tk6fd	222	5	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	222	6	is	be	VBZ
cord-310268-8q4tk6fd	222	7	an	an	DT
cord-310268-8q4tk6fd	222	8	effective	effective	JJ
cord-310268-8q4tk6fd	222	9	way	way	NN
cord-310268-8q4tk6fd	222	10	to	to	TO
cord-310268-8q4tk6fd	222	11	prolong	prolong	VB
cord-310268-8q4tk6fd	222	12	the	the	DT
cord-310268-8q4tk6fd	222	13	lifetime	lifetime	NN
cord-310268-8q4tk6fd	222	14	of	of	IN
cord-310268-8q4tk6fd	222	15	DNA	DNA	NNP
cord-310268-8q4tk6fd	222	16	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	222	17	in	in	IN
cord-310268-8q4tk6fd	222	18	the	the	DT
cord-310268-8q4tk6fd	222	19	biological	biological	JJ
cord-310268-8q4tk6fd	222	20	samples	sample	NNS
cord-310268-8q4tk6fd	222	21	.	.	.
cord-310268-8q4tk6fd	223	1	For	for	IN
cord-310268-8q4tk6fd	223	2	ultimate	ultimate	JJ
cord-310268-8q4tk6fd	223	3	success	success	NN
cord-310268-8q4tk6fd	223	4	,	,	,
cord-310268-8q4tk6fd	223	5	sufficient	sufficient	JJ
cord-310268-8q4tk6fd	223	6	studies	study	NNS
cord-310268-8q4tk6fd	223	7	with	with	IN
cord-310268-8q4tk6fd	223	8	clinical	clinical	JJ
cord-310268-8q4tk6fd	223	9	samples	sample	NNS
cord-310268-8q4tk6fd	223	10	or	or	CC
cord-310268-8q4tk6fd	223	11	in	in	IN
cord-310268-8q4tk6fd	223	12	vivo	vivo	NNP
cord-310268-8q4tk6fd	223	13	studies	study	NNS
cord-310268-8q4tk6fd	223	14	are	be	VBP
cord-310268-8q4tk6fd	223	15	indispensable	indispensable	JJ
cord-310268-8q4tk6fd	223	16	.	.	.
cord-310268-8q4tk6fd	224	1	Currently	currently	RB
cord-310268-8q4tk6fd	224	2	,	,	,
cord-310268-8q4tk6fd	224	3	although	although	IN
cord-310268-8q4tk6fd	224	4	most	most	JJS
cord-310268-8q4tk6fd	224	5	of	of	IN
cord-310268-8q4tk6fd	224	6	the	the	DT
cord-310268-8q4tk6fd	224	7	studies	study	NNS
cord-310268-8q4tk6fd	224	8	about	about	IN
cord-310268-8q4tk6fd	224	9	DNA	DNA	NNP
cord-310268-8q4tk6fd	224	10	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	224	11	based	base	VBN
cord-310268-8q4tk6fd	224	12	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	224	13	tools	tool	NNS
cord-310268-8q4tk6fd	224	14	for	for	IN
cord-310268-8q4tk6fd	224	15	human	human	JJ
cord-310268-8q4tk6fd	224	16	diseases	disease	NNS
cord-310268-8q4tk6fd	224	17	are	be	VBP
cord-310268-8q4tk6fd	224	18	still	still	RB
cord-310268-8q4tk6fd	224	19	in	in	IN
cord-310268-8q4tk6fd	224	20	the	the	DT
cord-310268-8q4tk6fd	224	21	primary	primary	JJ
cord-310268-8q4tk6fd	224	22	stage	stage	NN
cord-310268-8q4tk6fd	224	23	of	of	IN
cord-310268-8q4tk6fd	224	24	laboratory	laboratory	NN
cord-310268-8q4tk6fd	224	25	studies	study	NNS
cord-310268-8q4tk6fd	224	26	,	,	,
cord-310268-8q4tk6fd	224	27	some	some	DT
cord-310268-8q4tk6fd	224	28	of	of	IN
cord-310268-8q4tk6fd	224	29	them	-PRON-	PRP
cord-310268-8q4tk6fd	224	30	have	have	VBP
cord-310268-8q4tk6fd	224	31	gone	go	VBN
cord-310268-8q4tk6fd	224	32	further	far	RBR
cord-310268-8q4tk6fd	224	33	by	by	IN
cord-310268-8q4tk6fd	224	34	testing	test	VBG
cord-310268-8q4tk6fd	224	35	them	-PRON-	PRP
cord-310268-8q4tk6fd	224	36	with	with	IN
cord-310268-8q4tk6fd	224	37	clinical	clinical	JJ
cord-310268-8q4tk6fd	224	38	samples	sample	NNS
cord-310268-8q4tk6fd	224	39	and	and	CC
cord-310268-8q4tk6fd	224	40	animal	animal	NN
cord-310268-8q4tk6fd	224	41	studies	study	NNS
cord-310268-8q4tk6fd	224	42	in	in	IN
cord-310268-8q4tk6fd	224	43	vivo	vivo	NNP
cord-310268-8q4tk6fd	224	44	[	[	-LRB-
cord-310268-8q4tk6fd	224	45	30	30	CD
cord-310268-8q4tk6fd	224	46	,	,	,
cord-310268-8q4tk6fd	224	47	54	54	CD
cord-310268-8q4tk6fd	224	48	,	,	,
cord-310268-8q4tk6fd	224	49	59	59	CD
cord-310268-8q4tk6fd	224	50	,	,	,
cord-310268-8q4tk6fd	224	51	61	61	CD
cord-310268-8q4tk6fd	224	52	]	]	-RRB-
cord-310268-8q4tk6fd	224	53	.	.	.
cord-310268-8q4tk6fd	225	1	The	the	DT
cord-310268-8q4tk6fd	225	2	DNA	DNA	NNP
cord-310268-8q4tk6fd	225	3	aptamer	aptamer	NN
cord-310268-8q4tk6fd	225	4	XQ-2d	XQ-2d	.
cord-310268-8q4tk6fd	225	5	(	(	-LRB-
cord-310268-8q4tk6fd	225	6	Table	Table	NNP
cord-310268-8q4tk6fd	225	7	1	1	CD
cord-310268-8q4tk6fd	225	8	)	)	-RRB-
cord-310268-8q4tk6fd	225	9	that	that	WDT
cord-310268-8q4tk6fd	225	10	targets	target	VBZ
cord-310268-8q4tk6fd	225	11	the	the	DT
cord-310268-8q4tk6fd	225	12	pancreatic	pancreatic	JJ
cord-310268-8q4tk6fd	225	13	ductal	ductal	JJ
cord-310268-8q4tk6fd	225	14	adenocarcinomas	adenocarcinomas	NN
cord-310268-8q4tk6fd	225	15	(	(	-LRB-
cord-310268-8q4tk6fd	225	16	PDAC	PDAC	NNP
cord-310268-8q4tk6fd	225	17	)	)	-RRB-
cord-310268-8q4tk6fd	225	18	cells	cell	NNS
cord-310268-8q4tk6fd	225	19	has	have	VBZ
cord-310268-8q4tk6fd	225	20	been	be	VBN
cord-310268-8q4tk6fd	225	21	tested	test	VBN
cord-310268-8q4tk6fd	225	22	with	with	IN
cord-310268-8q4tk6fd	225	23	clinical	clinical	JJ
cord-310268-8q4tk6fd	225	24	PDAC	PDAC	NNP
cord-310268-8q4tk6fd	225	25	tissue	tissue	NN
cord-310268-8q4tk6fd	225	26	sections	section	NNS
cord-310268-8q4tk6fd	225	27	and	and	CC
cord-310268-8q4tk6fd	225	28	in	in	IN
cord-310268-8q4tk6fd	225	29	vivo	vivo	NN
cord-310268-8q4tk6fd	225	30	imaging	imaging	NN
cord-310268-8q4tk6fd	225	31	of	of	IN
cord-310268-8q4tk6fd	225	32	PDAC	PDAC	NNP
cord-310268-8q4tk6fd	225	33	tumor	tumor	NN
cord-310268-8q4tk6fd	225	34	-	-	HYPH
cord-310268-8q4tk6fd	225	35	bearing	bear	VBG
cord-310268-8q4tk6fd	225	36	mice	mouse	NNS
cord-310268-8q4tk6fd	225	37	[	[	-LRB-
cord-310268-8q4tk6fd	225	38	54	54	CD
cord-310268-8q4tk6fd	225	39	]	]	-RRB-
cord-310268-8q4tk6fd	225	40	.	.	.
cord-310268-8q4tk6fd	226	1	33	33	CD
cord-310268-8q4tk6fd	226	2	out	out	IN
cord-310268-8q4tk6fd	226	3	of	of	IN
cord-310268-8q4tk6fd	226	4	40	40	CD
cord-310268-8q4tk6fd	226	5	PDAC	PDAC	NNP
cord-310268-8q4tk6fd	226	6	tissues	tissue	NNS
cord-310268-8q4tk6fd	226	7	and	and	CC
cord-310268-8q4tk6fd	226	8	two	two	CD
cord-310268-8q4tk6fd	226	9	out	out	IN
cord-310268-8q4tk6fd	226	10	of	of	IN
cord-310268-8q4tk6fd	226	11	eight	eight	CD
cord-310268-8q4tk6fd	226	12	normal	normal	JJ
cord-310268-8q4tk6fd	226	13	pancreatic	pancreatic	JJ
cord-310268-8q4tk6fd	226	14	tissues	tissue	NNS
cord-310268-8q4tk6fd	226	15	were	be	VBD
cord-310268-8q4tk6fd	226	16	detected	detect	VBN
cord-310268-8q4tk6fd	226	17	by	by	IN
cord-310268-8q4tk6fd	226	18	the	the	DT
cord-310268-8q4tk6fd	226	19	Cy5-labeled	Cy5-labeled	NNP
cord-310268-8q4tk6fd	226	20	XQ-2d	XQ-2d	NNP
cord-310268-8q4tk6fd	226	21	.	.	.
cord-310268-8q4tk6fd	227	1	In	in	IN
cord-310268-8q4tk6fd	227	2	the	the	DT
cord-310268-8q4tk6fd	227	3	in	in	IN
cord-310268-8q4tk6fd	227	4	vivo	vivo	NN
cord-310268-8q4tk6fd	227	5	imaging	imaging	NN
cord-310268-8q4tk6fd	227	6	test	test	NN
cord-310268-8q4tk6fd	227	7	,	,	,
cord-310268-8q4tk6fd	227	8	Cy5-labeled	Cy5-labeled	NNP
cord-310268-8q4tk6fd	227	9	XQ-2d	XQ-2d	NNP
cord-310268-8q4tk6fd	227	10	was	be	VBD
cord-310268-8q4tk6fd	227	11	injected	inject	VBN
cord-310268-8q4tk6fd	227	12	into	into	IN
cord-310268-8q4tk6fd	227	13	the	the	DT
cord-310268-8q4tk6fd	227	14	BALB	BALB	NNP
cord-310268-8q4tk6fd	227	15	/	/	SYM
cord-310268-8q4tk6fd	227	16	c	c	NNP
cord-310268-8q4tk6fd	227	17	-	-	HYPH
cord-310268-8q4tk6fd	227	18	nude	nude	JJ
cord-310268-8q4tk6fd	227	19	mice	mouse	NNS
cord-310268-8q4tk6fd	227	20	grafted	graft	VBN
cord-310268-8q4tk6fd	227	21	with	with	IN
cord-310268-8q4tk6fd	227	22	PDAC	PDAC	NNP
cord-310268-8q4tk6fd	227	23	through	through	IN
cord-310268-8q4tk6fd	227	24	the	the	DT
cord-310268-8q4tk6fd	227	25	tail	tail	NN
cord-310268-8q4tk6fd	227	26	vein	vein	NN
cord-310268-8q4tk6fd	227	27	.	.	.
cord-310268-8q4tk6fd	228	1	It	-PRON-	PRP
cord-310268-8q4tk6fd	228	2	was	be	VBD
cord-310268-8q4tk6fd	228	3	found	find	VBN
cord-310268-8q4tk6fd	228	4	to	to	TO
cord-310268-8q4tk6fd	228	5	illuminate	illuminate	VB
cord-310268-8q4tk6fd	228	6	the	the	DT
cord-310268-8q4tk6fd	228	7	tumor	tumor	NN
cord-310268-8q4tk6fd	228	8	site	site	NN
cord-310268-8q4tk6fd	228	9	up	up	IN
cord-310268-8q4tk6fd	228	10	to	to	TO
cord-310268-8q4tk6fd	228	11	3	3	CD
cord-310268-8q4tk6fd	228	12	h	h	NN
cord-310268-8q4tk6fd	228	13	post	post	NN
cord-310268-8q4tk6fd	228	14	-	-	NN
cord-310268-8q4tk6fd	228	15	injection	injection	NN
cord-310268-8q4tk6fd	228	16	,	,	,
cord-310268-8q4tk6fd	228	17	while	while	IN
cord-310268-8q4tk6fd	228	18	the	the	DT
cord-310268-8q4tk6fd	228	19	Cy5-labeled	Cy5-labeled	NNP
cord-310268-8q4tk6fd	228	20	library	library	NN
cord-310268-8q4tk6fd	228	21	control	control	NN
cord-310268-8q4tk6fd	228	22	did	do	VBD
cord-310268-8q4tk6fd	228	23	not	not	RB
cord-310268-8q4tk6fd	228	24	give	give	VB
cord-310268-8q4tk6fd	228	25	any	any	DT
cord-310268-8q4tk6fd	228	26	signal	signal	NN
cord-310268-8q4tk6fd	228	27	.	.	.
cord-310268-8q4tk6fd	229	1	For	for	IN
cord-310268-8q4tk6fd	229	2	this	this	DT
cord-310268-8q4tk6fd	229	3	study	study	NN
cord-310268-8q4tk6fd	229	4	,	,	,
cord-310268-8q4tk6fd	229	5	both	both	DT
cord-310268-8q4tk6fd	229	6	phosphorothioate	phosphorothioate	NN
cord-310268-8q4tk6fd	229	7	and	and	CC
cord-310268-8q4tk6fd	229	8	2′-O	2′-o	CD
cord-310268-8q4tk6fd	229	9	-	-	HYPH
cord-310268-8q4tk6fd	229	10	methyl	methyl	NN
cord-310268-8q4tk6fd	229	11	modifications	modification	NNS
cord-310268-8q4tk6fd	229	12	were	be	VBD
cord-310268-8q4tk6fd	229	13	tried	try	VBN
cord-310268-8q4tk6fd	229	14	for	for	IN
cord-310268-8q4tk6fd	229	15	the	the	DT
cord-310268-8q4tk6fd	229	16	DNA	DNA	NNP
cord-310268-8q4tk6fd	229	17	aptamer	aptamer	NN
cord-310268-8q4tk6fd	229	18	.	.	.
cord-310268-8q4tk6fd	230	1	The	the	DT
cord-310268-8q4tk6fd	230	2	four	four	CD
cord-310268-8q4tk6fd	230	3	bases	basis	NNS
cord-310268-8q4tk6fd	230	4	at	at	IN
cord-310268-8q4tk6fd	230	5	the	the	DT
cord-310268-8q4tk6fd	230	6	5′	5′	CD
cord-310268-8q4tk6fd	230	7	and	and	CC
cord-310268-8q4tk6fd	230	8	3′	3′	CD
cord-310268-8q4tk6fd	230	9	termini	terminus	NNS
cord-310268-8q4tk6fd	230	10	of	of	IN
cord-310268-8q4tk6fd	230	11	XQ-2d	XQ-2d	NNPS
cord-310268-8q4tk6fd	230	12	were	be	VBD
cord-310268-8q4tk6fd	230	13	replaced	replace	VBN
cord-310268-8q4tk6fd	230	14	by	by	IN
cord-310268-8q4tk6fd	230	15	ether	ether	NN
cord-310268-8q4tk6fd	230	16	phosphorothioate	phosphorothioate	NN
cord-310268-8q4tk6fd	230	17	oligonucleotides	oligonucleotide	NNS
cord-310268-8q4tk6fd	230	18	or	or	CC
cord-310268-8q4tk6fd	230	19	2′-O	2′-o	CD
cord-310268-8q4tk6fd	230	20	-	-	HYPH
cord-310268-8q4tk6fd	230	21	methyl	methyl	NN
cord-310268-8q4tk6fd	230	22	oligonucleotides	oligonucleotide	NNS
cord-310268-8q4tk6fd	230	23	.	.	.
cord-310268-8q4tk6fd	231	1	However	however	RB
cord-310268-8q4tk6fd	231	2	,	,	,
cord-310268-8q4tk6fd	231	3	the	the	DT
cord-310268-8q4tk6fd	231	4	phosphorothioate	phosphorothioate	NN
cord-310268-8q4tk6fd	231	5	modification	modification	NN
cord-310268-8q4tk6fd	231	6	was	be	VBD
cord-310268-8q4tk6fd	231	7	The	the	DT
cord-310268-8q4tk6fd	231	8	signal	signal	NN
cord-310268-8q4tk6fd	231	9	-	-	HYPH
cord-310268-8q4tk6fd	231	10	molecule	molecule	NN
cord-310268-8q4tk6fd	231	11	-	-	HYPH
cord-310268-8q4tk6fd	231	12	labeled	label	VBN
cord-310268-8q4tk6fd	231	13	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	231	14	directly	directly	RB
cord-310268-8q4tk6fd	231	15	bind	bind	VB
cord-310268-8q4tk6fd	231	16	to	to	IN
cord-310268-8q4tk6fd	231	17	the	the	DT
cord-310268-8q4tk6fd	231	18	immobilized	immobilized	JJ
cord-310268-8q4tk6fd	231	19	or	or	CC
cord-310268-8q4tk6fd	231	20	free	free	JJ
cord-310268-8q4tk6fd	231	21	target	target	NN
cord-310268-8q4tk6fd	231	22	.	.	.
cord-310268-8q4tk6fd	232	1	The	the	DT
cord-310268-8q4tk6fd	232	2	signal	signal	NN
cord-310268-8q4tk6fd	232	3	molecules	molecule	NNS
cord-310268-8q4tk6fd	232	4	on	on	IN
cord-310268-8q4tk6fd	232	5	the	the	DT
cord-310268-8q4tk6fd	232	6	target	target	NN
cord-310268-8q4tk6fd	232	7	are	be	VBP
cord-310268-8q4tk6fd	232	8	detected	detect	VBN
cord-310268-8q4tk6fd	232	9	directly	directly	RB
cord-310268-8q4tk6fd	232	10	;	;	:
cord-310268-8q4tk6fd	232	11	(	(	-LRB-
cord-310268-8q4tk6fd	232	12	B	b	NN
cord-310268-8q4tk6fd	232	13	)	)	-RRB-
cord-310268-8q4tk6fd	232	14	Target	target	NN
cord-310268-8q4tk6fd	232	15	-	-	HYPH
cord-310268-8q4tk6fd	232	16	induced	induce	VBN
cord-310268-8q4tk6fd	232	17	structural	structural	JJ
cord-310268-8q4tk6fd	232	18	switching	switching	NN
cord-310268-8q4tk6fd	232	19	mode	mode	NN
cord-310268-8q4tk6fd	232	20	:	:	:
cord-310268-8q4tk6fd	232	21	A	a	DT
cord-310268-8q4tk6fd	232	22	fluorophore	fluorophore	RB
cord-310268-8q4tk6fd	232	23	-	-	HYPH
cord-310268-8q4tk6fd	232	24	labeled	label	VBN
cord-310268-8q4tk6fd	232	25	DNA	DNA	NNP
cord-310268-8q4tk6fd	232	26	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	232	27	forms	form	VBZ
cord-310268-8q4tk6fd	232	28	a	a	DT
cord-310268-8q4tk6fd	232	29	partial	partial	JJ
cord-310268-8q4tk6fd	232	30	duplex	duplex	NN
cord-310268-8q4tk6fd	232	31	with	with	IN
cord-310268-8q4tk6fd	232	32	a	a	DT
cord-310268-8q4tk6fd	232	33	small	small	JJ
cord-310268-8q4tk6fd	232	34	oligonucleotide	oligonucleotide	NN
cord-310268-8q4tk6fd	232	35	modified	modify	VBN
cord-310268-8q4tk6fd	232	36	with	with	IN
cord-310268-8q4tk6fd	232	37	a	a	DT
cord-310268-8q4tk6fd	232	38	quenching	quenching	NN
cord-310268-8q4tk6fd	232	39	moiety	moiety	NN
cord-310268-8q4tk6fd	232	40	(	(	-LRB-
cord-310268-8q4tk6fd	232	41	QDNA	QDNA	NNP
cord-310268-8q4tk6fd	232	42	)	)	-RRB-
cord-310268-8q4tk6fd	232	43	in	in	IN
cord-310268-8q4tk6fd	232	44	the	the	DT
cord-310268-8q4tk6fd	232	45	absence	absence	NN
cord-310268-8q4tk6fd	232	46	of	of	IN
cord-310268-8q4tk6fd	232	47	the	the	DT
cord-310268-8q4tk6fd	232	48	target	target	NN
cord-310268-8q4tk6fd	232	49	,	,	,
cord-310268-8q4tk6fd	232	50	bringing	bring	VBG
cord-310268-8q4tk6fd	232	51	the	the	DT
cord-310268-8q4tk6fd	232	52	fluorophore	fluorophore	NN
cord-310268-8q4tk6fd	232	53	(	(	-LRB-
cord-310268-8q4tk6fd	232	54	F	F	NNP
cord-310268-8q4tk6fd	232	55	)	)	-RRB-
cord-310268-8q4tk6fd	232	56	and	and	CC
cord-310268-8q4tk6fd	232	57	the	the	DT
cord-310268-8q4tk6fd	232	58	quencher	quencher	NN
cord-310268-8q4tk6fd	232	59	(	(	-LRB-
cord-310268-8q4tk6fd	232	60	Q	Q	NNP
cord-310268-8q4tk6fd	232	61	)	)	-RRB-
cord-310268-8q4tk6fd	232	62	into	into	IN
cord-310268-8q4tk6fd	232	63	close	close	JJ
cord-310268-8q4tk6fd	232	64	proximity	proximity	NN
cord-310268-8q4tk6fd	232	65	for	for	IN
cord-310268-8q4tk6fd	232	66	maximum	maximum	JJ
cord-310268-8q4tk6fd	232	67	fluorescence	fluorescence	NN
cord-310268-8q4tk6fd	232	68	quenching	quenching	NN
cord-310268-8q4tk6fd	232	69	.	.	.
cord-310268-8q4tk6fd	233	1	When	when	WRB
cord-310268-8q4tk6fd	233	2	the	the	DT
cord-310268-8q4tk6fd	233	3	target	target	NN
cord-310268-8q4tk6fd	233	4	is	be	VBZ
cord-310268-8q4tk6fd	233	5	introduced	introduce	VBN
cord-310268-8q4tk6fd	233	6	,	,	,
cord-310268-8q4tk6fd	233	7	the	the	DT
cord-310268-8q4tk6fd	233	8	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	233	9	prefers	prefer	VBZ
cord-310268-8q4tk6fd	233	10	to	to	TO
cord-310268-8q4tk6fd	233	11	form	form	VB
cord-310268-8q4tk6fd	233	12	the	the	DT
cord-310268-8q4tk6fd	233	13	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	233	14	-	-	HYPH
cord-310268-8q4tk6fd	233	15	target	target	NN
cord-310268-8q4tk6fd	233	16	complex	complex	NN
cord-310268-8q4tk6fd	233	17	.	.	.
cord-310268-8q4tk6fd	234	1	The	the	DT
cord-310268-8q4tk6fd	234	2	binding	binding	NN
cord-310268-8q4tk6fd	234	3	of	of	IN
cord-310268-8q4tk6fd	234	4	the	the	DT
cord-310268-8q4tk6fd	234	5	target	target	NN
cord-310268-8q4tk6fd	234	6	to	to	IN
cord-310268-8q4tk6fd	234	7	the	the	DT
cord-310268-8q4tk6fd	234	8	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	234	9	will	will	MD
cord-310268-8q4tk6fd	234	10	change	change	VB
cord-310268-8q4tk6fd	234	11	the	the	DT
cord-310268-8q4tk6fd	234	12	structure	structure	NN
cord-310268-8q4tk6fd	234	13	of	of	IN
cord-310268-8q4tk6fd	234	14	the	the	DT
cord-310268-8q4tk6fd	234	15	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	234	16	and	and	CC
cord-310268-8q4tk6fd	234	17	release	release	VB
cord-310268-8q4tk6fd	234	18	the	the	DT
cord-310268-8q4tk6fd	234	19	partially	partially	RB
cord-310268-8q4tk6fd	234	20	complementary	complementary	JJ
cord-310268-8q4tk6fd	234	21	quencher	quencher	NN
cord-310268-8q4tk6fd	234	22	,	,	,
cord-310268-8q4tk6fd	234	23	which	which	WDT
cord-310268-8q4tk6fd	234	24	will	will	MD
cord-310268-8q4tk6fd	234	25	trigger	trigger	VB
cord-310268-8q4tk6fd	234	26	the	the	DT
cord-310268-8q4tk6fd	234	27	increase	increase	NN
cord-310268-8q4tk6fd	234	28	of	of	IN
cord-310268-8q4tk6fd	234	29	the	the	DT
cord-310268-8q4tk6fd	234	30	signal	signal	NN
cord-310268-8q4tk6fd	234	31	;	;	:
cord-310268-8q4tk6fd	234	32	(	(	-LRB-
cord-310268-8q4tk6fd	234	33	C	C	NNP
cord-310268-8q4tk6fd	234	34	)	)	-RRB-
cord-310268-8q4tk6fd	234	35	Sandwich	sandwich	NN
cord-310268-8q4tk6fd	234	36	-	-	HYPH
cord-310268-8q4tk6fd	234	37	like	like	JJ
cord-310268-8q4tk6fd	234	38	mode	mode	NN
cord-310268-8q4tk6fd	234	39	:	:	:
cord-310268-8q4tk6fd	234	40	The	the	DT
cord-310268-8q4tk6fd	234	41	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	234	42	or	or	CC
cord-310268-8q4tk6fd	234	43	antibody	antibody	NN
cord-310268-8q4tk6fd	234	44	is	be	VBZ
cord-310268-8q4tk6fd	234	45	immobilized	immobilize	VBN
cord-310268-8q4tk6fd	234	46	on	on	IN
cord-310268-8q4tk6fd	234	47	the	the	DT
cord-310268-8q4tk6fd	234	48	solid	solid	JJ
cord-310268-8q4tk6fd	234	49	phase	phase	NN
cord-310268-8q4tk6fd	234	50	as	as	IN
cord-310268-8q4tk6fd	234	51	the	the	DT
cord-310268-8q4tk6fd	234	52	capturer	capturer	NN
cord-310268-8q4tk6fd	234	53	.	.	.
cord-310268-8q4tk6fd	235	1	The	the	DT
cord-310268-8q4tk6fd	235	2	captured	capture	VBN
cord-310268-8q4tk6fd	235	3	target	target	NN
cord-310268-8q4tk6fd	235	4	is	be	VBZ
cord-310268-8q4tk6fd	235	5	reported	report	VBN
cord-310268-8q4tk6fd	235	6	by	by	IN
cord-310268-8q4tk6fd	235	7	the	the	DT
cord-310268-8q4tk6fd	235	8	biotinylated	biotinylated	JJ
cord-310268-8q4tk6fd	235	9	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	235	10	,	,	,
cord-310268-8q4tk6fd	235	11	which	which	WDT
cord-310268-8q4tk6fd	235	12	displays	display	VBZ
cord-310268-8q4tk6fd	235	13	the	the	DT
cord-310268-8q4tk6fd	235	14	signal	signal	NN
cord-310268-8q4tk6fd	235	15	through	through	IN
cord-310268-8q4tk6fd	235	16	further	further	JJ
cord-310268-8q4tk6fd	235	17	binding	bind	VBG
cord-310268-8q4tk6fd	235	18	to	to	IN
cord-310268-8q4tk6fd	235	19	the	the	DT
cord-310268-8q4tk6fd	235	20	streptavidin	streptavidin	NN
cord-310268-8q4tk6fd	235	21	-	-	HYPH
cord-310268-8q4tk6fd	235	22	conjugated	conjugate	VBN
cord-310268-8q4tk6fd	235	23	HRP	HRP	NNP
cord-310268-8q4tk6fd	235	24	or	or	CC
cord-310268-8q4tk6fd	235	25	AuNP	aunp	NN
cord-310268-8q4tk6fd	235	26	;	;	:
cord-310268-8q4tk6fd	235	27	(	(	-LRB-
cord-310268-8q4tk6fd	235	28	D	D	NNP
cord-310268-8q4tk6fd	235	29	)	)	-RRB-
cord-310268-8q4tk6fd	235	30	Target	target	NN
cord-310268-8q4tk6fd	235	31	-	-	HYPH
cord-310268-8q4tk6fd	235	32	induced	induce	VBN
cord-310268-8q4tk6fd	235	33	dissociation	dissociation	NN
cord-310268-8q4tk6fd	235	34	mode	mode	NN
cord-310268-8q4tk6fd	235	35	:	:	:
cord-310268-8q4tk6fd	235	36	DNA	dna	NN
cord-310268-8q4tk6fd	235	37	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	235	38	coil	coil	NN
cord-310268-8q4tk6fd	235	39	around	around	IN
cord-310268-8q4tk6fd	235	40	the	the	DT
cord-310268-8q4tk6fd	235	41	surface	surface	NN
cord-310268-8q4tk6fd	235	42	of	of	IN
cord-310268-8q4tk6fd	235	43	the	the	DT
cord-310268-8q4tk6fd	235	44	gold	gold	NN
cord-310268-8q4tk6fd	235	45	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	235	46	(	(	-LRB-
cord-310268-8q4tk6fd	235	47	AuNPs	AuNPs	JJS
cord-310268-8q4tk6fd	235	48	)	)	-RRB-
cord-310268-8q4tk6fd	235	49	and	and	CC
cord-310268-8q4tk6fd	235	50	stop	stop	VB
cord-310268-8q4tk6fd	235	51	the	the	DT
cord-310268-8q4tk6fd	235	52	salt	salt	NN
cord-310268-8q4tk6fd	235	53	-	-	HYPH
cord-310268-8q4tk6fd	235	54	induced	induce	VBN
cord-310268-8q4tk6fd	235	55	aggregation	aggregation	NN
cord-310268-8q4tk6fd	235	56	of	of	IN
cord-310268-8q4tk6fd	235	57	AuNPs	AuNPs	NNP
cord-310268-8q4tk6fd	235	58	.	.	.
cord-310268-8q4tk6fd	236	1	When	when	WRB
cord-310268-8q4tk6fd	236	2	the	the	DT
cord-310268-8q4tk6fd	236	3	target	target	NN
cord-310268-8q4tk6fd	236	4	appears	appear	VBZ
cord-310268-8q4tk6fd	236	5	,	,	,
cord-310268-8q4tk6fd	236	6	the	the	DT
cord-310268-8q4tk6fd	236	7	DNA	dna	NN
cord-310268-8q4tk6fd	236	8	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	236	9	bind	bind	VBP
cord-310268-8q4tk6fd	236	10	to	to	IN
cord-310268-8q4tk6fd	236	11	the	the	DT
cord-310268-8q4tk6fd	236	12	target	target	NN
cord-310268-8q4tk6fd	236	13	and	and	CC
cord-310268-8q4tk6fd	236	14	release	release	NN
cord-310268-8q4tk6fd	236	15	from	from	IN
cord-310268-8q4tk6fd	236	16	the	the	DT
cord-310268-8q4tk6fd	236	17	AuNPs	AuNPs	NNP
cord-310268-8q4tk6fd	236	18	.	.	.
cord-310268-8q4tk6fd	237	1	The	the	DT
cord-310268-8q4tk6fd	237	2	AuNPs	AuNPs	NNP
cord-310268-8q4tk6fd	237	3	without	without	IN
cord-310268-8q4tk6fd	237	4	the	the	DT
cord-310268-8q4tk6fd	237	5	cover	cover	NN
cord-310268-8q4tk6fd	237	6	of	of	IN
cord-310268-8q4tk6fd	237	7	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	237	8	aggregate	aggregate	VBP
cord-310268-8q4tk6fd	237	9	in	in	IN
cord-310268-8q4tk6fd	237	10	the	the	DT
cord-310268-8q4tk6fd	237	11	salt	salt	NN
cord-310268-8q4tk6fd	237	12	solution	solution	NN
cord-310268-8q4tk6fd	237	13	and	and	CC
cord-310268-8q4tk6fd	237	14	change	change	VB
cord-310268-8q4tk6fd	237	15	color	color	NN
cord-310268-8q4tk6fd	237	16	from	from	IN
cord-310268-8q4tk6fd	237	17	red	red	JJ
cord-310268-8q4tk6fd	237	18	to	to	IN
cord-310268-8q4tk6fd	237	19	purple	purple	NN
cord-310268-8q4tk6fd	237	20	.	.	.
cord-310268-8q4tk6fd	238	1	One	one	CD
cord-310268-8q4tk6fd	238	2	of	of	IN
cord-310268-8q4tk6fd	238	3	the	the	DT
cord-310268-8q4tk6fd	238	4	biggest	big	JJS
cord-310268-8q4tk6fd	238	5	challenges	challenge	NNS
cord-310268-8q4tk6fd	238	6	for	for	IN
cord-310268-8q4tk6fd	238	7	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	238	8	-	-	HYPH
cord-310268-8q4tk6fd	238	9	based	base	VBN
cord-310268-8q4tk6fd	238	10	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	238	11	tools	tool	NNS
cord-310268-8q4tk6fd	238	12	and	and	CC
cord-310268-8q4tk6fd	238	13	their	-PRON-	PRP$
cord-310268-8q4tk6fd	238	14	clinical	clinical	JJ
cord-310268-8q4tk6fd	238	15	use	use	NN
cord-310268-8q4tk6fd	238	16	is	be	VBZ
cord-310268-8q4tk6fd	238	17	the	the	DT
cord-310268-8q4tk6fd	238	18	possible	possible	JJ
cord-310268-8q4tk6fd	238	19	invalidation	invalidation	NN
cord-310268-8q4tk6fd	238	20	in	in	IN
cord-310268-8q4tk6fd	238	21	a	a	DT
cord-310268-8q4tk6fd	238	22	real	real	JJ
cord-310268-8q4tk6fd	238	23	biological	biological	JJ
cord-310268-8q4tk6fd	238	24	environment	environment	NN
cord-310268-8q4tk6fd	238	25	as	as	IN
cord-310268-8q4tk6fd	238	26	a	a	DT
cord-310268-8q4tk6fd	238	27	result	result	NN
cord-310268-8q4tk6fd	238	28	of	of	IN
cord-310268-8q4tk6fd	238	29	degradation	degradation	NN
cord-310268-8q4tk6fd	238	30	from	from	IN
cord-310268-8q4tk6fd	238	31	nucleases	nuclease	NNS
cord-310268-8q4tk6fd	238	32	or	or	CC
cord-310268-8q4tk6fd	238	33	interference	interference	NN
cord-310268-8q4tk6fd	238	34	from	from	IN
cord-310268-8q4tk6fd	238	35	other	other	JJ
cord-310268-8q4tk6fd	238	36	matrix	matrix	NN
cord-310268-8q4tk6fd	238	37	factors	factor	NNS
cord-310268-8q4tk6fd	238	38	.	.	.
cord-310268-8q4tk6fd	239	1	Using	use	VBG
cord-310268-8q4tk6fd	239	2	chemical	chemical	NN
cord-310268-8q4tk6fd	239	3	modified	modify	VBN
cord-310268-8q4tk6fd	239	4	DNA	DNA	NNP
cord-310268-8q4tk6fd	239	5	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	239	6	is	be	VBZ
cord-310268-8q4tk6fd	239	7	an	an	DT
cord-310268-8q4tk6fd	239	8	effective	effective	JJ
cord-310268-8q4tk6fd	239	9	way	way	NN
cord-310268-8q4tk6fd	239	10	to	to	TO
cord-310268-8q4tk6fd	239	11	prolong	prolong	VB
cord-310268-8q4tk6fd	239	12	the	the	DT
cord-310268-8q4tk6fd	239	13	lifetime	lifetime	NN
cord-310268-8q4tk6fd	239	14	of	of	IN
cord-310268-8q4tk6fd	239	15	DNA	DNA	NNP
cord-310268-8q4tk6fd	239	16	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	239	17	in	in	IN
cord-310268-8q4tk6fd	239	18	the	the	DT
cord-310268-8q4tk6fd	239	19	biological	biological	JJ
cord-310268-8q4tk6fd	239	20	samples	sample	NNS
cord-310268-8q4tk6fd	239	21	.	.	.
cord-310268-8q4tk6fd	240	1	For	for	IN
cord-310268-8q4tk6fd	240	2	ultimate	ultimate	JJ
cord-310268-8q4tk6fd	240	3	success	success	NN
cord-310268-8q4tk6fd	240	4	,	,	,
cord-310268-8q4tk6fd	240	5	sufficient	sufficient	JJ
cord-310268-8q4tk6fd	240	6	studies	study	NNS
cord-310268-8q4tk6fd	240	7	with	with	IN
cord-310268-8q4tk6fd	240	8	clinical	clinical	JJ
cord-310268-8q4tk6fd	240	9	samples	sample	NNS
cord-310268-8q4tk6fd	240	10	or	or	CC
cord-310268-8q4tk6fd	240	11	in	in	IN
cord-310268-8q4tk6fd	240	12	vivo	vivo	NNP
cord-310268-8q4tk6fd	240	13	studies	study	NNS
cord-310268-8q4tk6fd	240	14	are	be	VBP
cord-310268-8q4tk6fd	240	15	indispensable	indispensable	JJ
cord-310268-8q4tk6fd	240	16	.	.	.
cord-310268-8q4tk6fd	241	1	Currently	currently	RB
cord-310268-8q4tk6fd	241	2	,	,	,
cord-310268-8q4tk6fd	241	3	although	although	IN
cord-310268-8q4tk6fd	241	4	most	most	JJS
cord-310268-8q4tk6fd	241	5	of	of	IN
cord-310268-8q4tk6fd	241	6	the	the	DT
cord-310268-8q4tk6fd	241	7	studies	study	NNS
cord-310268-8q4tk6fd	241	8	about	about	IN
cord-310268-8q4tk6fd	241	9	DNA	DNA	NNP
cord-310268-8q4tk6fd	241	10	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	241	11	based	base	VBN
cord-310268-8q4tk6fd	241	12	diagnostic	diagnostic	JJ
cord-310268-8q4tk6fd	241	13	tools	tool	NNS
cord-310268-8q4tk6fd	241	14	for	for	IN
cord-310268-8q4tk6fd	241	15	human	human	JJ
cord-310268-8q4tk6fd	241	16	diseases	disease	NNS
cord-310268-8q4tk6fd	241	17	are	be	VBP
cord-310268-8q4tk6fd	241	18	still	still	RB
cord-310268-8q4tk6fd	241	19	in	in	IN
cord-310268-8q4tk6fd	241	20	the	the	DT
cord-310268-8q4tk6fd	241	21	primary	primary	JJ
cord-310268-8q4tk6fd	241	22	stage	stage	NN
cord-310268-8q4tk6fd	241	23	of	of	IN
cord-310268-8q4tk6fd	241	24	laboratory	laboratory	NN
cord-310268-8q4tk6fd	241	25	studies	study	NNS
cord-310268-8q4tk6fd	241	26	,	,	,
cord-310268-8q4tk6fd	241	27	some	some	DT
cord-310268-8q4tk6fd	241	28	of	of	IN
cord-310268-8q4tk6fd	241	29	them	-PRON-	PRP
cord-310268-8q4tk6fd	241	30	have	have	VBP
cord-310268-8q4tk6fd	241	31	gone	go	VBN
cord-310268-8q4tk6fd	241	32	further	far	RBR
cord-310268-8q4tk6fd	241	33	by	by	IN
cord-310268-8q4tk6fd	241	34	testing	test	VBG
cord-310268-8q4tk6fd	241	35	them	-PRON-	PRP
cord-310268-8q4tk6fd	241	36	with	with	IN
cord-310268-8q4tk6fd	241	37	clinical	clinical	JJ
cord-310268-8q4tk6fd	241	38	samples	sample	NNS
cord-310268-8q4tk6fd	241	39	and	and	CC
cord-310268-8q4tk6fd	241	40	animal	animal	NN
cord-310268-8q4tk6fd	241	41	studies	study	NNS
cord-310268-8q4tk6fd	241	42	in	in	IN
cord-310268-8q4tk6fd	241	43	vivo	vivo	NNP
cord-310268-8q4tk6fd	241	44	[	[	-LRB-
cord-310268-8q4tk6fd	241	45	30	30	CD
cord-310268-8q4tk6fd	241	46	,	,	,
cord-310268-8q4tk6fd	241	47	54	54	CD
cord-310268-8q4tk6fd	241	48	,	,	,
cord-310268-8q4tk6fd	241	49	59	59	CD
cord-310268-8q4tk6fd	241	50	,	,	,
cord-310268-8q4tk6fd	241	51	61	61	CD
cord-310268-8q4tk6fd	241	52	]	]	-RRB-
cord-310268-8q4tk6fd	241	53	.	.	.
cord-310268-8q4tk6fd	242	1	The	the	DT
cord-310268-8q4tk6fd	242	2	DNA	DNA	NNP
cord-310268-8q4tk6fd	242	3	aptamer	aptamer	NN
cord-310268-8q4tk6fd	242	4	XQ-2d	XQ-2d	.
cord-310268-8q4tk6fd	242	5	(	(	-LRB-
cord-310268-8q4tk6fd	242	6	Table	Table	NNP
cord-310268-8q4tk6fd	242	7	1	1	CD
cord-310268-8q4tk6fd	242	8	)	)	-RRB-
cord-310268-8q4tk6fd	242	9	that	that	WDT
cord-310268-8q4tk6fd	242	10	targets	target	VBZ
cord-310268-8q4tk6fd	242	11	the	the	DT
cord-310268-8q4tk6fd	242	12	pancreatic	pancreatic	JJ
cord-310268-8q4tk6fd	242	13	ductal	ductal	JJ
cord-310268-8q4tk6fd	242	14	adenocarcinomas	adenocarcinomas	NN
cord-310268-8q4tk6fd	242	15	(	(	-LRB-
cord-310268-8q4tk6fd	242	16	PDAC	PDAC	NNP
cord-310268-8q4tk6fd	242	17	)	)	-RRB-
cord-310268-8q4tk6fd	242	18	cells	cell	NNS
cord-310268-8q4tk6fd	242	19	has	have	VBZ
cord-310268-8q4tk6fd	242	20	been	be	VBN
cord-310268-8q4tk6fd	242	21	tested	test	VBN
cord-310268-8q4tk6fd	242	22	with	with	IN
cord-310268-8q4tk6fd	242	23	clinical	clinical	JJ
cord-310268-8q4tk6fd	242	24	PDAC	PDAC	NNP
cord-310268-8q4tk6fd	242	25	tissue	tissue	NN
cord-310268-8q4tk6fd	242	26	sections	section	NNS
cord-310268-8q4tk6fd	242	27	and	and	CC
cord-310268-8q4tk6fd	242	28	in	in	IN
cord-310268-8q4tk6fd	242	29	vivo	vivo	NN
cord-310268-8q4tk6fd	242	30	imaging	imaging	NN
cord-310268-8q4tk6fd	242	31	of	of	IN
cord-310268-8q4tk6fd	242	32	PDAC	PDAC	NNP
cord-310268-8q4tk6fd	242	33	tumor	tumor	NN
cord-310268-8q4tk6fd	242	34	-	-	HYPH
cord-310268-8q4tk6fd	242	35	bearing	bear	VBG
cord-310268-8q4tk6fd	242	36	mice	mouse	NNS
cord-310268-8q4tk6fd	242	37	[	[	-LRB-
cord-310268-8q4tk6fd	242	38	54	54	CD
cord-310268-8q4tk6fd	242	39	]	]	-RRB-
cord-310268-8q4tk6fd	242	40	.	.	.
cord-310268-8q4tk6fd	243	1	33	33	CD
cord-310268-8q4tk6fd	243	2	out	out	IN
cord-310268-8q4tk6fd	243	3	of	of	IN
cord-310268-8q4tk6fd	243	4	40	40	CD
cord-310268-8q4tk6fd	243	5	PDAC	PDAC	NNP
cord-310268-8q4tk6fd	243	6	tissues	tissue	NNS
cord-310268-8q4tk6fd	243	7	and	and	CC
cord-310268-8q4tk6fd	243	8	two	two	CD
cord-310268-8q4tk6fd	243	9	out	out	IN
cord-310268-8q4tk6fd	243	10	of	of	IN
cord-310268-8q4tk6fd	243	11	eight	eight	CD
cord-310268-8q4tk6fd	243	12	normal	normal	JJ
cord-310268-8q4tk6fd	243	13	pancreatic	pancreatic	JJ
cord-310268-8q4tk6fd	243	14	tissues	tissue	NNS
cord-310268-8q4tk6fd	243	15	were	be	VBD
cord-310268-8q4tk6fd	243	16	detected	detect	VBN
cord-310268-8q4tk6fd	243	17	by	by	IN
cord-310268-8q4tk6fd	243	18	the	the	DT
cord-310268-8q4tk6fd	243	19	Cy5-labeled	Cy5-labeled	NNP
cord-310268-8q4tk6fd	243	20	XQ-2d	XQ-2d	NNP
cord-310268-8q4tk6fd	243	21	.	.	.
cord-310268-8q4tk6fd	244	1	In	in	IN
cord-310268-8q4tk6fd	244	2	the	the	DT
cord-310268-8q4tk6fd	244	3	in	in	IN
cord-310268-8q4tk6fd	244	4	vivo	vivo	NN
cord-310268-8q4tk6fd	244	5	imaging	imaging	NN
cord-310268-8q4tk6fd	244	6	test	test	NN
cord-310268-8q4tk6fd	244	7	,	,	,
cord-310268-8q4tk6fd	244	8	Cy5-labeled	Cy5-labeled	NNP
cord-310268-8q4tk6fd	244	9	XQ-2d	XQ-2d	NNP
cord-310268-8q4tk6fd	244	10	was	be	VBD
cord-310268-8q4tk6fd	244	11	injected	inject	VBN
cord-310268-8q4tk6fd	244	12	into	into	IN
cord-310268-8q4tk6fd	244	13	the	the	DT
cord-310268-8q4tk6fd	244	14	BALB	BALB	NNP
cord-310268-8q4tk6fd	244	15	/	/	SYM
cord-310268-8q4tk6fd	244	16	c	c	NNP
cord-310268-8q4tk6fd	244	17	-	-	HYPH
cord-310268-8q4tk6fd	244	18	nude	nude	JJ
cord-310268-8q4tk6fd	244	19	mice	mouse	NNS
cord-310268-8q4tk6fd	244	20	grafted	graft	VBN
cord-310268-8q4tk6fd	244	21	with	with	IN
cord-310268-8q4tk6fd	244	22	PDAC	PDAC	NNP
cord-310268-8q4tk6fd	244	23	through	through	IN
cord-310268-8q4tk6fd	244	24	the	the	DT
cord-310268-8q4tk6fd	244	25	tail	tail	NN
cord-310268-8q4tk6fd	244	26	vein	vein	NN
cord-310268-8q4tk6fd	244	27	.	.	.
cord-310268-8q4tk6fd	245	1	It	-PRON-	PRP
cord-310268-8q4tk6fd	245	2	was	be	VBD
cord-310268-8q4tk6fd	245	3	found	find	VBN
cord-310268-8q4tk6fd	245	4	to	to	TO
cord-310268-8q4tk6fd	245	5	illuminate	illuminate	VB
cord-310268-8q4tk6fd	245	6	the	the	DT
cord-310268-8q4tk6fd	245	7	tumor	tumor	NN
cord-310268-8q4tk6fd	245	8	site	site	NN
cord-310268-8q4tk6fd	245	9	up	up	IN
cord-310268-8q4tk6fd	245	10	to	to	TO
cord-310268-8q4tk6fd	245	11	3	3	CD
cord-310268-8q4tk6fd	245	12	h	h	NN
cord-310268-8q4tk6fd	245	13	post	post	NN
cord-310268-8q4tk6fd	245	14	-	-	NN
cord-310268-8q4tk6fd	245	15	injection	injection	NN
cord-310268-8q4tk6fd	245	16	,	,	,
cord-310268-8q4tk6fd	245	17	while	while	IN
cord-310268-8q4tk6fd	245	18	the	the	DT
cord-310268-8q4tk6fd	245	19	Cy5-labeled	Cy5-labeled	NNP
cord-310268-8q4tk6fd	245	20	library	library	NN
cord-310268-8q4tk6fd	245	21	control	control	NN
cord-310268-8q4tk6fd	245	22	did	do	VBD
cord-310268-8q4tk6fd	245	23	not	not	RB
cord-310268-8q4tk6fd	245	24	give	give	VB
cord-310268-8q4tk6fd	245	25	any	any	DT
cord-310268-8q4tk6fd	245	26	signal	signal	NN
cord-310268-8q4tk6fd	245	27	.	.	.
cord-310268-8q4tk6fd	246	1	For	for	IN
cord-310268-8q4tk6fd	246	2	this	this	DT
cord-310268-8q4tk6fd	246	3	study	study	NN
cord-310268-8q4tk6fd	246	4	,	,	,
cord-310268-8q4tk6fd	246	5	both	both	DT
cord-310268-8q4tk6fd	246	6	phosphorothioate	phosphorothioate	NN
cord-310268-8q4tk6fd	246	7	and	and	CC
cord-310268-8q4tk6fd	246	8	2	2	CD
cord-310268-8q4tk6fd	246	9	1	1	CD
cord-310268-8q4tk6fd	246	10	-O	-o	CD
cord-310268-8q4tk6fd	246	11	-	-	HYPH
cord-310268-8q4tk6fd	246	12	methyl	methyl	NN
cord-310268-8q4tk6fd	246	13	modifications	modification	NNS
cord-310268-8q4tk6fd	246	14	were	be	VBD
cord-310268-8q4tk6fd	246	15	tried	try	VBN
cord-310268-8q4tk6fd	246	16	for	for	IN
cord-310268-8q4tk6fd	246	17	the	the	DT
cord-310268-8q4tk6fd	246	18	DNA	DNA	NNP
cord-310268-8q4tk6fd	246	19	aptamer	aptamer	NN
cord-310268-8q4tk6fd	246	20	.	.	.
cord-310268-8q4tk6fd	247	1	The	the	DT
cord-310268-8q4tk6fd	247	2	four	four	CD
cord-310268-8q4tk6fd	247	3	bases	basis	NNS
cord-310268-8q4tk6fd	247	4	at	at	IN
cord-310268-8q4tk6fd	247	5	the	the	DT
cord-310268-8q4tk6fd	247	6	5	5	CD
cord-310268-8q4tk6fd	247	7	1	1	CD
cord-310268-8q4tk6fd	247	8	and	and	CC
cord-310268-8q4tk6fd	247	9	3	3	CD
cord-310268-8q4tk6fd	247	10	1	1	CD
cord-310268-8q4tk6fd	247	11	termini	terminus	NNS
cord-310268-8q4tk6fd	247	12	of	of	IN
cord-310268-8q4tk6fd	247	13	XQ-2d	XQ-2d	NNPS
cord-310268-8q4tk6fd	247	14	were	be	VBD
cord-310268-8q4tk6fd	247	15	replaced	replace	VBN
cord-310268-8q4tk6fd	247	16	by	by	IN
cord-310268-8q4tk6fd	247	17	ether	ether	NN
cord-310268-8q4tk6fd	247	18	phosphorothioate	phosphorothioate	NN
cord-310268-8q4tk6fd	247	19	oligonucleotides	oligonucleotide	NNS
cord-310268-8q4tk6fd	247	20	or	or	CC
cord-310268-8q4tk6fd	247	21	2	2	CD
cord-310268-8q4tk6fd	247	22	1	1	CD
cord-310268-8q4tk6fd	247	23	-O	-o	CD
cord-310268-8q4tk6fd	247	24	-	-	HYPH
cord-310268-8q4tk6fd	247	25	methyl	methyl	JJ
cord-310268-8q4tk6fd	247	26	oligonucleotides	oligonucleotide	NNS
cord-310268-8q4tk6fd	247	27	.	.	.
cord-310268-8q4tk6fd	248	1	However	however	RB
cord-310268-8q4tk6fd	248	2	,	,	,
cord-310268-8q4tk6fd	248	3	the	the	DT
cord-310268-8q4tk6fd	248	4	phosphorothioate	phosphorothioate	NN
cord-310268-8q4tk6fd	248	5	modification	modification	NN
cord-310268-8q4tk6fd	248	6	was	be	VBD
cord-310268-8q4tk6fd	248	7	found	find	VBN
cord-310268-8q4tk6fd	248	8	to	to	TO
cord-310268-8q4tk6fd	248	9	weaken	weaken	VB
cord-310268-8q4tk6fd	248	10	the	the	DT
cord-310268-8q4tk6fd	248	11	binding	binding	JJ
cord-310268-8q4tk6fd	248	12	ability	ability	NN
cord-310268-8q4tk6fd	248	13	of	of	IN
cord-310268-8q4tk6fd	248	14	the	the	DT
cord-310268-8q4tk6fd	248	15	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	248	16	,	,	,
cord-310268-8q4tk6fd	248	17	whereas	whereas	IN
cord-310268-8q4tk6fd	248	18	the	the	DT
cord-310268-8q4tk6fd	248	19	2	2	CD
cord-310268-8q4tk6fd	248	20	1	1	CD
cord-310268-8q4tk6fd	248	21	-O	-o	CD
cord-310268-8q4tk6fd	248	22	-	-	HYPH
cord-310268-8q4tk6fd	248	23	methyl	methyl	JJ
cord-310268-8q4tk6fd	248	24	modification	modification	NN
cord-310268-8q4tk6fd	248	25	did	do	VBD
cord-310268-8q4tk6fd	248	26	not	not	RB
cord-310268-8q4tk6fd	248	27	significantly	significantly	RB
cord-310268-8q4tk6fd	248	28	affect	affect	VB
cord-310268-8q4tk6fd	248	29	the	the	DT
cord-310268-8q4tk6fd	248	30	binding	bind	VBG
cord-310268-8q4tk6fd	248	31	ability	ability	NN
cord-310268-8q4tk6fd	248	32	.	.	.
cord-310268-8q4tk6fd	249	1	Moreover	moreover	RB
cord-310268-8q4tk6fd	249	2	,	,	,
cord-310268-8q4tk6fd	249	3	the	the	DT
cord-310268-8q4tk6fd	249	4	2	2	CD
cord-310268-8q4tk6fd	249	5	1	1	CD
cord-310268-8q4tk6fd	249	6	-O	-o	CD
cord-310268-8q4tk6fd	249	7	-	-	HYPH
cord-310268-8q4tk6fd	249	8	methyl	methyl	NN
cord-310268-8q4tk6fd	249	9	modified	modify	VBN
cord-310268-8q4tk6fd	249	10	XQ-2d	XQ-2d	NNP
cord-310268-8q4tk6fd	249	11	could	could	MD
cord-310268-8q4tk6fd	249	12	last	last	VB
cord-310268-8q4tk6fd	249	13	for	for	IN
cord-310268-8q4tk6fd	249	14	36	36	CD
cord-310268-8q4tk6fd	249	15	h	h	NN
cord-310268-8q4tk6fd	249	16	in	in	IN
cord-310268-8q4tk6fd	249	17	10	10	CD
cord-310268-8q4tk6fd	249	18	%	%	NN
cord-310268-8q4tk6fd	249	19	FBS	fbs	NN
cord-310268-8q4tk6fd	249	20	medium	medium	NN
cord-310268-8q4tk6fd	249	21	,	,	,
cord-310268-8q4tk6fd	249	22	but	but	CC
cord-310268-8q4tk6fd	249	23	the	the	DT
cord-310268-8q4tk6fd	249	24	unmodified	unmodified	JJ
cord-310268-8q4tk6fd	249	25	XQ-2d	XQ-2d	NNP
cord-310268-8q4tk6fd	249	26	was	be	VBD
cord-310268-8q4tk6fd	249	27	completely	completely	RB
cord-310268-8q4tk6fd	249	28	degraded	degrade	VBN
cord-310268-8q4tk6fd	249	29	after	after	IN
cord-310268-8q4tk6fd	249	30	24-h	24-h	JJ
cord-310268-8q4tk6fd	249	31	incubation	incubation	NN
cord-310268-8q4tk6fd	249	32	.	.	.
cord-310268-8q4tk6fd	250	1	An	an	DT
cord-310268-8q4tk6fd	250	2	important	important	JJ
cord-310268-8q4tk6fd	250	3	application	application	NN
cord-310268-8q4tk6fd	250	4	of	of	IN
cord-310268-8q4tk6fd	250	5	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	250	6	is	be	VBZ
cord-310268-8q4tk6fd	250	7	their	-PRON-	PRP$
cord-310268-8q4tk6fd	250	8	use	use	NN
cord-310268-8q4tk6fd	250	9	as	as	IN
cord-310268-8q4tk6fd	250	10	small	small	JJ
cord-310268-8q4tk6fd	250	11	-	-	HYPH
cord-310268-8q4tk6fd	250	12	molecule	molecule	NN
cord-310268-8q4tk6fd	250	13	therapeutic	therapeutic	JJ
cord-310268-8q4tk6fd	250	14	agents	agent	NNS
cord-310268-8q4tk6fd	250	15	.	.	.
cord-310268-8q4tk6fd	251	1	DNA	DNA	NNP
cord-310268-8q4tk6fd	251	2	aptamers	aptamers	NNP
cord-310268-8q4tk6fd	251	3	exhibit	exhibit	VBP
cord-310268-8q4tk6fd	251	4	significant	significant	JJ
cord-310268-8q4tk6fd	251	5	advantages	advantage	NNS
cord-310268-8q4tk6fd	251	6	in	in	IN
cord-310268-8q4tk6fd	251	7	therapeutic	therapeutic	JJ
cord-310268-8q4tk6fd	251	8	application	application	NN
cord-310268-8q4tk6fd	251	9	and	and	CC
cord-310268-8q4tk6fd	251	10	have	have	VBP
cord-310268-8q4tk6fd	251	11	been	be	VBN
cord-310268-8q4tk6fd	251	12	developed	develop	VBN
cord-310268-8q4tk6fd	251	13	as	as	IN
cord-310268-8q4tk6fd	251	14	attractive	attractive	JJ
cord-310268-8q4tk6fd	251	15	therapeutic	therapeutic	JJ
cord-310268-8q4tk6fd	251	16	agents	agent	NNS
cord-310268-8q4tk6fd	251	17	in	in	IN
cord-310268-8q4tk6fd	251	18	competition	competition	NN
cord-310268-8q4tk6fd	251	19	with	with	IN
cord-310268-8q4tk6fd	251	20	antibodies	antibody	NNS
cord-310268-8q4tk6fd	251	21	.	.	.
cord-310268-8q4tk6fd	252	1	Generally	generally	RB
cord-310268-8q4tk6fd	252	2	,	,	,
cord-310268-8q4tk6fd	252	3	DNA	DNA	NNP
cord-310268-8q4tk6fd	252	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	252	5	used	use	VBN
cord-310268-8q4tk6fd	252	6	for	for	IN
cord-310268-8q4tk6fd	252	7	therapeutic	therapeutic	JJ
cord-310268-8q4tk6fd	252	8	applications	application	NNS
cord-310268-8q4tk6fd	252	9	function	function	VBP
cord-310268-8q4tk6fd	252	10	in	in	IN
cord-310268-8q4tk6fd	252	11	two	two	CD
cord-310268-8q4tk6fd	252	12	ways	way	NNS
cord-310268-8q4tk6fd	252	13	.	.	.
cord-310268-8q4tk6fd	253	1	First	first	RB
cord-310268-8q4tk6fd	253	2	,	,	,
cord-310268-8q4tk6fd	253	3	DNA	DNA	NNP
cord-310268-8q4tk6fd	253	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	253	5	can	can	MD
cord-310268-8q4tk6fd	253	6	inhibit	inhibit	VB
cord-310268-8q4tk6fd	253	7	protein	protein	NN
cord-310268-8q4tk6fd	253	8	-	-	HYPH
cord-310268-8q4tk6fd	253	9	protein	protein	NN
cord-310268-8q4tk6fd	253	10	interactions	interaction	NNS
cord-310268-8q4tk6fd	253	11	by	by	IN
cord-310268-8q4tk6fd	253	12	specifically	specifically	RB
cord-310268-8q4tk6fd	253	13	binding	bind	VBG
cord-310268-8q4tk6fd	253	14	to	to	IN
cord-310268-8q4tk6fd	253	15	the	the	DT
cord-310268-8q4tk6fd	253	16	target	target	NN
cord-310268-8q4tk6fd	253	17	protein	protein	NN
cord-310268-8q4tk6fd	253	18	and	and	CC
cord-310268-8q4tk6fd	253	19	thereby	thereby	RB
cord-310268-8q4tk6fd	253	20	functioning	function	VBG
cord-310268-8q4tk6fd	253	21	as	as	IN
cord-310268-8q4tk6fd	253	22	antagonists	antagonist	NNS
cord-310268-8q4tk6fd	253	23	.	.	.
cord-310268-8q4tk6fd	254	1	Second	second	RB
cord-310268-8q4tk6fd	254	2	,	,	,
cord-310268-8q4tk6fd	254	3	DNA	DNA	NNP
cord-310268-8q4tk6fd	254	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	254	5	can	can	MD
cord-310268-8q4tk6fd	254	6	function	function	VB
cord-310268-8q4tk6fd	254	7	as	as	IN
cord-310268-8q4tk6fd	254	8	agonists	agonist	NNS
cord-310268-8q4tk6fd	254	9	,	,	,
cord-310268-8q4tk6fd	254	10	which	which	WDT
cord-310268-8q4tk6fd	254	11	promotes	promote	VBZ
cord-310268-8q4tk6fd	254	12	the	the	DT
cord-310268-8q4tk6fd	254	13	function	function	NN
cord-310268-8q4tk6fd	254	14	of	of	IN
cord-310268-8q4tk6fd	254	15	the	the	DT
cord-310268-8q4tk6fd	254	16	target	target	NN
cord-310268-8q4tk6fd	254	17	protein	protein	NN
cord-310268-8q4tk6fd	254	18	upon	upon	IN
cord-310268-8q4tk6fd	254	19	binding	bind	VBG
cord-310268-8q4tk6fd	254	20	to	to	IN
cord-310268-8q4tk6fd	254	21	the	the	DT
cord-310268-8q4tk6fd	254	22	target	target	NN
cord-310268-8q4tk6fd	254	23	protein	protein	NN
cord-310268-8q4tk6fd	254	24	.	.	.
cord-310268-8q4tk6fd	255	1	Although	although	IN
cord-310268-8q4tk6fd	255	2	DNA	DNA	NNP
cord-310268-8q4tk6fd	255	3	aptamers	aptamers	NNP
cord-310268-8q4tk6fd	255	4	act	act	VBP
cord-310268-8q4tk6fd	255	5	similarly	similarly	RB
cord-310268-8q4tk6fd	255	6	to	to	IN
cord-310268-8q4tk6fd	255	7	antibodies	antibody	NNS
cord-310268-8q4tk6fd	255	8	,	,	,
cord-310268-8q4tk6fd	255	9	the	the	DT
cord-310268-8q4tk6fd	255	10	non	non	NN
cord-310268-8q4tk6fd	255	11	-	-	JJ
cord-310268-8q4tk6fd	255	12	immunogenicity	immunogenicity	NN
cord-310268-8q4tk6fd	255	13	of	of	IN
cord-310268-8q4tk6fd	255	14	DNA	dna	NN
cord-310268-8q4tk6fd	255	15	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	255	16	make	make	VBP
cord-310268-8q4tk6fd	255	17	it	-PRON-	PRP
cord-310268-8q4tk6fd	255	18	more	more	RBR
cord-310268-8q4tk6fd	255	19	notable	notable	JJ
cord-310268-8q4tk6fd	255	20	in	in	IN
cord-310268-8q4tk6fd	255	21	therapeutics	therapeutic	NNS
cord-310268-8q4tk6fd	255	22	.	.	.
cord-310268-8q4tk6fd	256	1	Compared	compare	VBN
cord-310268-8q4tk6fd	256	2	with	with	IN
cord-310268-8q4tk6fd	256	3	antibodies	antibody	NNS
cord-310268-8q4tk6fd	256	4	,	,	,
cord-310268-8q4tk6fd	256	5	DNA	DNA	NNP
cord-310268-8q4tk6fd	256	6	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	256	7	are	be	VBP
cord-310268-8q4tk6fd	256	8	easier	easy	JJR
cord-310268-8q4tk6fd	256	9	to	to	TO
cord-310268-8q4tk6fd	256	10	uptake	uptake	VB
cord-310268-8q4tk6fd	256	11	because	because	IN
cord-310268-8q4tk6fd	256	12	of	of	IN
cord-310268-8q4tk6fd	256	13	their	-PRON-	PRP$
cord-310268-8q4tk6fd	256	14	small	small	JJ
cord-310268-8q4tk6fd	256	15	size	size	NN
cord-310268-8q4tk6fd	256	16	.	.	.
cord-310268-8q4tk6fd	257	1	Importantly	importantly	RB
cord-310268-8q4tk6fd	257	2	,	,	,
cord-310268-8q4tk6fd	257	3	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	257	4	can	can	MD
cord-310268-8q4tk6fd	257	5	specifically	specifically	RB
cord-310268-8q4tk6fd	257	6	recognize	recognize	VB
cord-310268-8q4tk6fd	257	7	a	a	DT
cord-310268-8q4tk6fd	257	8	wide	wide	JJ
cord-310268-8q4tk6fd	257	9	range	range	NN
cord-310268-8q4tk6fd	257	10	of	of	IN
cord-310268-8q4tk6fd	257	11	targets	target	NNS
cord-310268-8q4tk6fd	257	12	including	include	VBG
cord-310268-8q4tk6fd	257	13	small	small	JJ
cord-310268-8q4tk6fd	257	14	molecules	molecule	NNS
cord-310268-8q4tk6fd	257	15	,	,	,
cord-310268-8q4tk6fd	257	16	proteins	protein	NNS
cord-310268-8q4tk6fd	257	17	and	and	CC
cord-310268-8q4tk6fd	257	18	cells	cell	NNS
cord-310268-8q4tk6fd	257	19	.	.	.
cord-310268-8q4tk6fd	258	1	Moreover	moreover	RB
cord-310268-8q4tk6fd	258	2	,	,	,
cord-310268-8q4tk6fd	258	3	given	give	VBN
cord-310268-8q4tk6fd	258	4	that	that	IN
cord-310268-8q4tk6fd	258	5	DNA	dna	NN
cord-310268-8q4tk6fd	258	6	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	258	7	can	can	MD
cord-310268-8q4tk6fd	258	8	be	be	VB
cord-310268-8q4tk6fd	258	9	designed	design	VBN
cord-310268-8q4tk6fd	258	10	and	and	CC
cord-310268-8q4tk6fd	258	11	selected	select	VBN
cord-310268-8q4tk6fd	258	12	in	in	IN
cord-310268-8q4tk6fd	258	13	vitro	vitro	FW
cord-310268-8q4tk6fd	258	14	,	,	,
cord-310268-8q4tk6fd	258	15	they	-PRON-	PRP
cord-310268-8q4tk6fd	258	16	have	have	VBP
cord-310268-8q4tk6fd	258	17	lower	low	JJR
cord-310268-8q4tk6fd	258	18	production	production	NN
cord-310268-8q4tk6fd	258	19	cost	cost	NN
cord-310268-8q4tk6fd	258	20	than	than	IN
cord-310268-8q4tk6fd	258	21	antibodies	antibody	NNS
cord-310268-8q4tk6fd	258	22	.	.	.
cord-310268-8q4tk6fd	259	1	The	the	DT
cord-310268-8q4tk6fd	259	2	properties	property	NNS
cord-310268-8q4tk6fd	259	3	and	and	CC
cord-310268-8q4tk6fd	259	4	advantages	advantage	NNS
cord-310268-8q4tk6fd	259	5	of	of	IN
cord-310268-8q4tk6fd	259	6	DNA	dna	NN
cord-310268-8q4tk6fd	259	7	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	259	8	mentioned	mention	VBN
cord-310268-8q4tk6fd	259	9	above	above	RB
cord-310268-8q4tk6fd	259	10	facilitate	facilitate	VBP
cord-310268-8q4tk6fd	259	11	the	the	DT
cord-310268-8q4tk6fd	259	12	promising	promising	JJ
cord-310268-8q4tk6fd	259	13	application	application	NN
cord-310268-8q4tk6fd	259	14	of	of	IN
cord-310268-8q4tk6fd	259	15	DNA	DNA	NNP
cord-310268-8q4tk6fd	259	16	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	259	17	in	in	IN
cord-310268-8q4tk6fd	259	18	the	the	DT
cord-310268-8q4tk6fd	259	19	field	field	NN
cord-310268-8q4tk6fd	259	20	of	of	IN
cord-310268-8q4tk6fd	259	21	therapeutics	therapeutic	NNS
cord-310268-8q4tk6fd	259	22	.	.	.
cord-310268-8q4tk6fd	260	1	Although	although	IN
cord-310268-8q4tk6fd	260	2	there	there	EX
cord-310268-8q4tk6fd	260	3	are	be	VBP
cord-310268-8q4tk6fd	260	4	currently	currently	RB
cord-310268-8q4tk6fd	260	5	no	no	DT
cord-310268-8q4tk6fd	260	6	DNA	DNA	NNP
cord-310268-8q4tk6fd	260	7	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	260	8	therapeutics	therapeutic	NNS
cord-310268-8q4tk6fd	260	9	in	in	IN
cord-310268-8q4tk6fd	260	10	clinical	clinical	JJ
cord-310268-8q4tk6fd	260	11	use	use	NN
cord-310268-8q4tk6fd	260	12	,	,	,
cord-310268-8q4tk6fd	260	13	four	four	CD
cord-310268-8q4tk6fd	260	14	DNA	dna	NN
cord-310268-8q4tk6fd	260	15	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	260	16	are	be	VBP
cord-310268-8q4tk6fd	260	17	being	be	VBG
cord-310268-8q4tk6fd	260	18	evaluated	evaluate	VBN
cord-310268-8q4tk6fd	260	19	in	in	IN
cord-310268-8q4tk6fd	260	20	clinical	clinical	JJ
cord-310268-8q4tk6fd	260	21	trials	trial	NNS
cord-310268-8q4tk6fd	260	22	for	for	IN
cord-310268-8q4tk6fd	260	23	their	-PRON-	PRP$
cord-310268-8q4tk6fd	260	24	effect	effect	NN
cord-310268-8q4tk6fd	260	25	on	on	IN
cord-310268-8q4tk6fd	260	26	hematological	hematological	JJ
cord-310268-8q4tk6fd	260	27	disease	disease	NN
cord-310268-8q4tk6fd	260	28	,	,	,
cord-310268-8q4tk6fd	260	29	macular	macular	JJ
cord-310268-8q4tk6fd	260	30	degeneration	degeneration	NN
cord-310268-8q4tk6fd	260	31	disease	disease	NN
cord-310268-8q4tk6fd	260	32	and	and	CC
cord-310268-8q4tk6fd	260	33	cancer	cancer	NN
cord-310268-8q4tk6fd	260	34	(	(	-LRB-
cord-310268-8q4tk6fd	260	35	Table	Table	NNP
cord-310268-8q4tk6fd	260	36	2	2	CD
cord-310268-8q4tk6fd	260	37	)	)	-RRB-
cord-310268-8q4tk6fd	260	38	.	.	.
cord-310268-8q4tk6fd	261	1	AS1411	as1411	NN
cord-310268-8q4tk6fd	261	2	(	(	-LRB-
cord-310268-8q4tk6fd	261	3	Antisoma	Antisoma	NNP
cord-310268-8q4tk6fd	261	4	)	)	-RRB-
cord-310268-8q4tk6fd	261	5	is	be	VBZ
cord-310268-8q4tk6fd	261	6	a	a	DT
cord-310268-8q4tk6fd	261	7	guanine	guanine	NN
cord-310268-8q4tk6fd	261	8	-	-	HYPH
cord-310268-8q4tk6fd	261	9	rich	rich	JJ
cord-310268-8q4tk6fd	261	10	aptamer	aptamer	NN
cord-310268-8q4tk6fd	261	11	with	with	IN
cord-310268-8q4tk6fd	261	12	a	a	DT
cord-310268-8q4tk6fd	261	13	guanine	guanine	JJ
cord-310268-8q4tk6fd	261	14	quadruplex	quadruplex	NN
cord-310268-8q4tk6fd	261	15	structure	structure	NN
cord-310268-8q4tk6fd	261	16	,	,	,
cord-310268-8q4tk6fd	261	17	targeting	target	VBG
cord-310268-8q4tk6fd	261	18	nucleolin	nucleolin	NNP
cord-310268-8q4tk6fd	261	19	.	.	.
cord-310268-8q4tk6fd	262	1	Nucleolin	Nucleolin	NNP
cord-310268-8q4tk6fd	262	2	is	be	VBZ
cord-310268-8q4tk6fd	262	3	a	a	DT
cord-310268-8q4tk6fd	262	4	eukaryotic	eukaryotic	JJ
cord-310268-8q4tk6fd	262	5	nucleolar	nucleolar	NN
cord-310268-8q4tk6fd	262	6	phosphoprotein	phosphoprotein	NN
cord-310268-8q4tk6fd	262	7	that	that	WDT
cord-310268-8q4tk6fd	262	8	is	be	VBZ
cord-310268-8q4tk6fd	262	9	involved	involve	VBN
cord-310268-8q4tk6fd	262	10	in	in	IN
cord-310268-8q4tk6fd	262	11	the	the	DT
cord-310268-8q4tk6fd	262	12	synthesis	synthesis	NN
cord-310268-8q4tk6fd	262	13	and	and	CC
cord-310268-8q4tk6fd	262	14	maturation	maturation	NN
cord-310268-8q4tk6fd	262	15	of	of	IN
cord-310268-8q4tk6fd	262	16	ribosomes	ribosome	NNS
cord-310268-8q4tk6fd	262	17	and	and	CC
cord-310268-8q4tk6fd	262	18	has	have	VBZ
cord-310268-8q4tk6fd	262	19	been	be	VBN
cord-310268-8q4tk6fd	262	20	reported	report	VBN
cord-310268-8q4tk6fd	262	21	as	as	IN
cord-310268-8q4tk6fd	262	22	a	a	DT
cord-310268-8q4tk6fd	262	23	target	target	NN
cord-310268-8q4tk6fd	262	24	for	for	IN
cord-310268-8q4tk6fd	262	25	anti	anti	JJ
cord-310268-8q4tk6fd	262	26	-	-	JJ
cord-310268-8q4tk6fd	262	27	cancer	cancer	JJ
cord-310268-8q4tk6fd	262	28	therapies	therapy	NNS
cord-310268-8q4tk6fd	262	29	.	.	.
cord-310268-8q4tk6fd	263	1	The	the	DT
cord-310268-8q4tk6fd	263	2	guanine	guanine	JJ
cord-310268-8q4tk6fd	263	3	quadruplex	quadruplex	NN
cord-310268-8q4tk6fd	263	4	structure	structure	NN
cord-310268-8q4tk6fd	263	5	can	can	MD
cord-310268-8q4tk6fd	263	6	help	help	VB
cord-310268-8q4tk6fd	263	7	to	to	TO
cord-310268-8q4tk6fd	263	8	enhance	enhance	VB
cord-310268-8q4tk6fd	263	9	the	the	DT
cord-310268-8q4tk6fd	263	10	nuclease	nuclease	FW
cord-310268-8q4tk6fd	263	11	degradation	degradation	NN
cord-310268-8q4tk6fd	263	12	resistance	resistance	NN
cord-310268-8q4tk6fd	263	13	and	and	CC
cord-310268-8q4tk6fd	263	14	cell	cell	NN
cord-310268-8q4tk6fd	263	15	uptake	uptake	NN
cord-310268-8q4tk6fd	263	16	of	of	IN
cord-310268-8q4tk6fd	263	17	AS1411	as1411	NN
cord-310268-8q4tk6fd	263	18	.	.	.
cord-310268-8q4tk6fd	264	1	AS1411	as1411	NN
cord-310268-8q4tk6fd	264	2	possesses	possess	VBZ
cord-310268-8q4tk6fd	264	3	anti	anti	JJ
cord-310268-8q4tk6fd	264	4	-	-	JJ
cord-310268-8q4tk6fd	264	5	cancer	cancer	JJ
cord-310268-8q4tk6fd	264	6	activity	activity	NN
cord-310268-8q4tk6fd	264	7	against	against	IN
cord-310268-8q4tk6fd	264	8	breast	breast	NN
cord-310268-8q4tk6fd	264	9	cancer	cancer	NN
cord-310268-8q4tk6fd	264	10	cells	cell	NNS
cord-310268-8q4tk6fd	264	11	[	[	-LRB-
cord-310268-8q4tk6fd	264	12	92	92	CD
cord-310268-8q4tk6fd	264	13	]	]	-RRB-
cord-310268-8q4tk6fd	264	14	,	,	,
cord-310268-8q4tk6fd	264	15	metastatic	metastatic	JJ
cord-310268-8q4tk6fd	264	16	renal	renal	JJ
cord-310268-8q4tk6fd	264	17	cell	cell	NN
cord-310268-8q4tk6fd	264	18	carcinoma	carcinoma	NN
cord-310268-8q4tk6fd	264	19	[	[	-LRB-
cord-310268-8q4tk6fd	264	20	93	93	CD
cord-310268-8q4tk6fd	264	21	]	]	-RRB-
cord-310268-8q4tk6fd	264	22	and	and	CC
cord-310268-8q4tk6fd	264	23	acute	acute	JJ
cord-310268-8q4tk6fd	264	24	myeloid	myeloid	NN
cord-310268-8q4tk6fd	264	25	leukemia	leukemia	NN
cord-310268-8q4tk6fd	264	26	[	[	-LRB-
cord-310268-8q4tk6fd	264	27	94	94	CD
cord-310268-8q4tk6fd	264	28	]	]	-RRB-
cord-310268-8q4tk6fd	264	29	.	.	.
cord-310268-8q4tk6fd	265	1	The	the	DT
cord-310268-8q4tk6fd	265	2	phase	phase	NN
cord-310268-8q4tk6fd	265	3	2	2	CD
cord-310268-8q4tk6fd	265	4	clinical	clinical	JJ
cord-310268-8q4tk6fd	265	5	trial	trial	NN
cord-310268-8q4tk6fd	265	6	for	for	IN
cord-310268-8q4tk6fd	265	7	using	use	VBG
cord-310268-8q4tk6fd	265	8	AS1411	as1411	NN
cord-310268-8q4tk6fd	265	9	to	to	TO
cord-310268-8q4tk6fd	265	10	treat	treat	VB
cord-310268-8q4tk6fd	265	11	renal	renal	JJ
cord-310268-8q4tk6fd	265	12	cell	cell	NN
cord-310268-8q4tk6fd	265	13	carcinoma	carcinoma	NN
cord-310268-8q4tk6fd	265	14	was	be	VBD
cord-310268-8q4tk6fd	265	15	completed	complete	VBN
cord-310268-8q4tk6fd	265	16	in	in	IN
cord-310268-8q4tk6fd	265	17	2009	2009	CD
cord-310268-8q4tk6fd	266	1	(	(	-LRB-
cord-310268-8q4tk6fd	266	2	NCT00740441	NCT00740441	NNP
cord-310268-8q4tk6fd	266	3	)	)	-RRB-
cord-310268-8q4tk6fd	266	4	,	,	,
cord-310268-8q4tk6fd	266	5	while	while	IN
cord-310268-8q4tk6fd	266	6	another	another	DT
cord-310268-8q4tk6fd	266	7	phase	phase	NN
cord-310268-8q4tk6fd	266	8	2	2	CD
cord-310268-8q4tk6fd	266	9	clinical	clinical	JJ
cord-310268-8q4tk6fd	266	10	trial	trial	NN
cord-310268-8q4tk6fd	266	11	for	for	IN
cord-310268-8q4tk6fd	266	12	treating	treat	VBG
cord-310268-8q4tk6fd	266	13	acute	acute	JJ
cord-310268-8q4tk6fd	266	14	myeloid	myeloid	JJ
cord-310268-8q4tk6fd	266	15	leukemia	leukemia	NN
cord-310268-8q4tk6fd	266	16	was	be	VBD
cord-310268-8q4tk6fd	266	17	completed	complete	VBN
cord-310268-8q4tk6fd	266	18	in	in	IN
cord-310268-8q4tk6fd	266	19	2011	2011	CD
cord-310268-8q4tk6fd	267	1	(	(	-LRB-
cord-310268-8q4tk6fd	267	2	NCT01034410	NCT01034410	NNP
cord-310268-8q4tk6fd	267	3	and	and	CC
cord-310268-8q4tk6fd	267	4	NCT01034410	NCT01034410	NNP
cord-310268-8q4tk6fd	267	5	)	)	-RRB-
cord-310268-8q4tk6fd	267	6	.	.	.
cord-310268-8q4tk6fd	268	1	ARC1779	ARC1779	NNP
cord-310268-8q4tk6fd	269	1	(	(	-LRB-
cord-310268-8q4tk6fd	269	2	Achemix	Achemix	NNP
cord-310268-8q4tk6fd	269	3	)	)	-RRB-
cord-310268-8q4tk6fd	269	4	,	,	,
cord-310268-8q4tk6fd	269	5	a	a	DT
cord-310268-8q4tk6fd	269	6	PEGylated	pegylate	VBN
cord-310268-8q4tk6fd	269	7	DNA	dna	NN
cord-310268-8q4tk6fd	269	8	aptamer	aptamer	NN
cord-310268-8q4tk6fd	269	9	,	,	,
cord-310268-8q4tk6fd	269	10	recognizes	recognize	VBZ
cord-310268-8q4tk6fd	269	11	platelet	platelet	NN
cord-310268-8q4tk6fd	269	12	ligand	ligand	NN
cord-310268-8q4tk6fd	269	13	receptor	receptor	NN
cord-310268-8q4tk6fd	269	14	von	von	NNP
cord-310268-8q4tk6fd	269	15	Willebrand	Willebrand	NNP
cord-310268-8q4tk6fd	269	16	factor	factor	NN
cord-310268-8q4tk6fd	269	17	that	that	WDT
cord-310268-8q4tk6fd	269	18	mediates	mediate	VBZ
cord-310268-8q4tk6fd	269	19	platelet	platelet	NN
cord-310268-8q4tk6fd	269	20	recruitment	recruitment	NN
cord-310268-8q4tk6fd	269	21	.	.	.
cord-310268-8q4tk6fd	270	1	ARC1779	ARC1779	NNP
cord-310268-8q4tk6fd	271	1	blocks	block	VBZ
cord-310268-8q4tk6fd	271	2	the	the	DT
cord-310268-8q4tk6fd	271	3	binding	binding	NN
cord-310268-8q4tk6fd	271	4	between	between	IN
cord-310268-8q4tk6fd	271	5	von	von	NNP
cord-310268-8q4tk6fd	271	6	Willebrand	Willebrand	NNP
cord-310268-8q4tk6fd	271	7	factor	factor	NN
cord-310268-8q4tk6fd	271	8	and	and	CC
cord-310268-8q4tk6fd	271	9	the	the	DT
cord-310268-8q4tk6fd	271	10	platelet	platelet	NN
cord-310268-8q4tk6fd	271	11	,	,	,
cord-310268-8q4tk6fd	271	12	thereby	thereby	RB
cord-310268-8q4tk6fd	271	13	inducing	induce	VBG
cord-310268-8q4tk6fd	271	14	an	an	DT
cord-310268-8q4tk6fd	271	15	antithrombotic	antithrombotic	JJ
cord-310268-8q4tk6fd	271	16	effect	effect	NN
cord-310268-8q4tk6fd	271	17	.	.	.
cord-310268-8q4tk6fd	272	1	The	the	DT
cord-310268-8q4tk6fd	272	2	efficacy	efficacy	NN
cord-310268-8q4tk6fd	272	3	of	of	IN
cord-310268-8q4tk6fd	272	4	ARC1779	ARC1779	NNP
cord-310268-8q4tk6fd	272	5	in	in	IN
cord-310268-8q4tk6fd	272	6	platelet	platelet	NN
cord-310268-8q4tk6fd	272	7	inhibition	inhibition	NN
cord-310268-8q4tk6fd	272	8	has	have	VBZ
cord-310268-8q4tk6fd	272	9	been	be	VBN
cord-310268-8q4tk6fd	272	10	demonstrated	demonstrate	VBN
cord-310268-8q4tk6fd	272	11	and	and	CC
cord-310268-8q4tk6fd	272	12	a	a	DT
cord-310268-8q4tk6fd	272	13	phase	phase	NN
cord-310268-8q4tk6fd	272	14	2	2	CD
cord-310268-8q4tk6fd	272	15	clinical	clinical	JJ
cord-310268-8q4tk6fd	272	16	trial	trial	NN
cord-310268-8q4tk6fd	272	17	for	for	IN
cord-310268-8q4tk6fd	272	18	treating	treat	VBG
cord-310268-8q4tk6fd	272	19	von	von	NNP
cord-310268-8q4tk6fd	272	20	Willebrand	Willebrand	NNP
cord-310268-8q4tk6fd	272	21	factor	factor	NN
cord-310268-8q4tk6fd	272	22	related	relate	VBN
cord-310268-8q4tk6fd	272	23	platelet	platelet	NN
cord-310268-8q4tk6fd	272	24	function	function	NN
cord-310268-8q4tk6fd	272	25	disorders	disorder	NNS
cord-310268-8q4tk6fd	272	26	(	(	-LRB-
cord-310268-8q4tk6fd	272	27	NCT00632242	NCT00632242	NNP
cord-310268-8q4tk6fd	272	28	)	)	-RRB-
cord-310268-8q4tk6fd	272	29	has	have	VBZ
cord-310268-8q4tk6fd	272	30	been	be	VBN
cord-310268-8q4tk6fd	272	31	completed	complete	VBN
cord-310268-8q4tk6fd	272	32	.	.	.
cord-310268-8q4tk6fd	273	1	Recent	recent	JJ
cord-310268-8q4tk6fd	273	2	studies	study	NNS
cord-310268-8q4tk6fd	273	3	show	show	VBP
cord-310268-8q4tk6fd	273	4	that	that	IN
cord-310268-8q4tk6fd	273	5	ARC1779	ARC1779	NNP
cord-310268-8q4tk6fd	273	6	can	can	MD
cord-310268-8q4tk6fd	273	7	effectively	effectively	RB
cord-310268-8q4tk6fd	273	8	prevent	prevent	VB
cord-310268-8q4tk6fd	273	9	thromboembolism	thromboembolism	NN
cord-310268-8q4tk6fd	273	10	[	[	-LRB-
cord-310268-8q4tk6fd	273	11	95	95	CD
cord-310268-8q4tk6fd	273	12	]	]	-RRB-
cord-310268-8q4tk6fd	273	13	.	.	.
cord-310268-8q4tk6fd	274	1	A	a	DT
cord-310268-8q4tk6fd	274	2	phase	phase	NN
cord-310268-8q4tk6fd	274	3	2	2	CD
cord-310268-8q4tk6fd	274	4	clinical	clinical	JJ
cord-310268-8q4tk6fd	274	5	study	study	NN
cord-310268-8q4tk6fd	274	6	shows	show	VBZ
cord-310268-8q4tk6fd	274	7	that	that	IN
cord-310268-8q4tk6fd	274	8	ARC1779	ARC1779	NNP
cord-310268-8q4tk6fd	274	9	exhibits	exhibit	VBZ
cord-310268-8q4tk6fd	274	10	favorable	favorable	JJ
cord-310268-8q4tk6fd	274	11	pharmacokinetic	pharmacokinetic	JJ
cord-310268-8q4tk6fd	274	12	,	,	,
cord-310268-8q4tk6fd	274	13	pharmacodynamic	pharmacodynamic	JJ
cord-310268-8q4tk6fd	274	14	and	and	CC
cord-310268-8q4tk6fd	274	15	safety	safety	NN
cord-310268-8q4tk6fd	274	16	properties	property	NNS
cord-310268-8q4tk6fd	274	17	in	in	IN
cord-310268-8q4tk6fd	274	18	patients	patient	NNS
cord-310268-8q4tk6fd	274	19	with	with	IN
cord-310268-8q4tk6fd	274	20	congenital	congenital	JJ
cord-310268-8q4tk6fd	274	21	thrombotic	thrombotic	JJ
cord-310268-8q4tk6fd	274	22	thrombocytopenic	thrombocytopenic	JJ
cord-310268-8q4tk6fd	274	23	purpura	purpura	NN
cord-310268-8q4tk6fd	274	24	[	[	-LRB-
cord-310268-8q4tk6fd	274	25	96	96	CD
cord-310268-8q4tk6fd	274	26	]	]	-RRB-
cord-310268-8q4tk6fd	274	27	.	.	.
cord-310268-8q4tk6fd	275	1	NU172	NU172	NNP
cord-310268-8q4tk6fd	276	1	(	(	-LRB-
cord-310268-8q4tk6fd	276	2	ARCA	ARCA	NNP
cord-310268-8q4tk6fd	276	3	biopharma	biopharma	NNP
cord-310268-8q4tk6fd	276	4	)	)	-RRB-
cord-310268-8q4tk6fd	276	5	is	be	VBZ
cord-310268-8q4tk6fd	276	6	an	an	DT
cord-310268-8q4tk6fd	276	7	unmodified	unmodified	JJ
cord-310268-8q4tk6fd	276	8	DNA	dna	NN
cord-310268-8q4tk6fd	276	9	aptamer	aptamer	NN
cord-310268-8q4tk6fd	276	10	targeting	target	VBG
cord-310268-8q4tk6fd	276	11	thrombin	thrombin	NN
cord-310268-8q4tk6fd	276	12	,	,	,
cord-310268-8q4tk6fd	276	13	which	which	WDT
cord-310268-8q4tk6fd	276	14	can	can	MD
cord-310268-8q4tk6fd	276	15	prolong	prolong	VB
cord-310268-8q4tk6fd	276	16	blood	blood	NN
cord-310268-8q4tk6fd	276	17	clotting	clotting	NN
cord-310268-8q4tk6fd	276	18	.	.	.
cord-310268-8q4tk6fd	277	1	The	the	DT
cord-310268-8q4tk6fd	277	2	phase	phase	NN
cord-310268-8q4tk6fd	277	3	2	2	CD
cord-310268-8q4tk6fd	277	4	clinical	clinical	JJ
cord-310268-8q4tk6fd	277	5	trial	trial	NN
cord-310268-8q4tk6fd	277	6	using	use	VBG
cord-310268-8q4tk6fd	277	7	NU172	NU172	NNP
cord-310268-8q4tk6fd	277	8	as	as	IN
cord-310268-8q4tk6fd	277	9	anticoagulation	anticoagulation	NN
cord-310268-8q4tk6fd	277	10	agent	agent	NN
cord-310268-8q4tk6fd	277	11	in	in	IN
cord-310268-8q4tk6fd	277	12	patients	patient	NNS
cord-310268-8q4tk6fd	277	13	undergoing	undergo	VBG
cord-310268-8q4tk6fd	277	14	off	off	IN
cord-310268-8q4tk6fd	277	15	-	-	HYPH
cord-310268-8q4tk6fd	277	16	pump	pump	NN
cord-310268-8q4tk6fd	277	17	coronary	coronary	JJ
cord-310268-8q4tk6fd	277	18	artery	artery	NN
cord-310268-8q4tk6fd	277	19	bypass	bypass	NN
cord-310268-8q4tk6fd	277	20	graft	graft	NN
cord-310268-8q4tk6fd	277	21	(	(	-LRB-
cord-310268-8q4tk6fd	277	22	CABG	CABG	NNP
cord-310268-8q4tk6fd	277	23	)	)	-RRB-
cord-310268-8q4tk6fd	277	24	surgery	surgery	NN
cord-310268-8q4tk6fd	277	25	(	(	-LRB-
cord-310268-8q4tk6fd	277	26	SNAP	snap	VB
cord-310268-8q4tk6fd	277	27	-	-	HYPH
cord-310268-8q4tk6fd	277	28	CABG	CABG	NNP
cord-310268-8q4tk6fd	277	29	-	-	HYPH
cord-310268-8q4tk6fd	277	30	OFF	off	NN
cord-310268-8q4tk6fd	277	31	)	)	-RRB-
cord-310268-8q4tk6fd	277	32	has	have	VBZ
cord-310268-8q4tk6fd	277	33	been	be	VBN
cord-310268-8q4tk6fd	277	34	completed	complete	VBN
cord-310268-8q4tk6fd	277	35	(	(	-LRB-
cord-310268-8q4tk6fd	277	36	NCT00808964	NCT00808964	NNP
cord-310268-8q4tk6fd	277	37	)	)	-RRB-
cord-310268-8q4tk6fd	277	38	.	.	.
cord-310268-8q4tk6fd	278	1	E10030	e10030	NN
cord-310268-8q4tk6fd	279	1	(	(	-LRB-
cord-310268-8q4tk6fd	279	2	Ophthotech	Ophthotech	NNP
cord-310268-8q4tk6fd	279	3	)	)	-RRB-
cord-310268-8q4tk6fd	279	4	,	,	,
cord-310268-8q4tk6fd	279	5	a	a	DT
cord-310268-8q4tk6fd	279	6	PEGylated	pegylate	VBN
cord-310268-8q4tk6fd	279	7	DNA	dna	NN
cord-310268-8q4tk6fd	279	8	aptamer	aptamer	NN
cord-310268-8q4tk6fd	279	9	,	,	,
cord-310268-8q4tk6fd	279	10	functions	function	NNS
cord-310268-8q4tk6fd	279	11	as	as	IN
cord-310268-8q4tk6fd	279	12	an	an	DT
cord-310268-8q4tk6fd	279	13	antagonist	antagonist	NN
cord-310268-8q4tk6fd	279	14	of	of	IN
cord-310268-8q4tk6fd	279	15	platelet	platelet	NN
cord-310268-8q4tk6fd	279	16	-	-	HYPH
cord-310268-8q4tk6fd	279	17	derived	derive	VBN
cord-310268-8q4tk6fd	279	18	growth	growth	NN
cord-310268-8q4tk6fd	279	19	factor	factor	NN
cord-310268-8q4tk6fd	279	20	.	.	.
cord-310268-8q4tk6fd	280	1	E10030	e10030	NN
cord-310268-8q4tk6fd	281	1	in	in	IN
cord-310268-8q4tk6fd	281	2	combination	combination	NN
cord-310268-8q4tk6fd	281	3	with	with	IN
cord-310268-8q4tk6fd	281	4	anti	anti	JJ
cord-310268-8q4tk6fd	281	5	-	-	JJ
cord-310268-8q4tk6fd	281	6	VEGF	vegf	JJ
cord-310268-8q4tk6fd	281	7	agent	agent	NN
cord-310268-8q4tk6fd	281	8	can	can	MD
cord-310268-8q4tk6fd	281	9	effectively	effectively	RB
cord-310268-8q4tk6fd	281	10	prevent	prevent	VB
cord-310268-8q4tk6fd	281	11	angiogenesis	angiogenesis	NN
cord-310268-8q4tk6fd	281	12	[	[	-LRB-
cord-310268-8q4tk6fd	281	13	97	97	CD
cord-310268-8q4tk6fd	281	14	]	]	-RRB-
cord-310268-8q4tk6fd	281	15	.	.	.
cord-310268-8q4tk6fd	282	1	Currently	currently	RB
cord-310268-8q4tk6fd	282	2	,	,	,
cord-310268-8q4tk6fd	282	3	a	a	DT
cord-310268-8q4tk6fd	282	4	phase	phase	NN
cord-310268-8q4tk6fd	282	5	3	3	CD
cord-310268-8q4tk6fd	282	6	clinical	clinical	JJ
cord-310268-8q4tk6fd	282	7	study	study	NN
cord-310268-8q4tk6fd	282	8	of	of	IN
cord-310268-8q4tk6fd	282	9	E10030	e10030	NN
cord-310268-8q4tk6fd	282	10	in	in	IN
cord-310268-8q4tk6fd	282	11	combination	combination	NN
cord-310268-8q4tk6fd	282	12	with	with	IN
cord-310268-8q4tk6fd	282	13	ranibizumab	ranibizumab	NN
cord-310268-8q4tk6fd	282	14	(	(	-LRB-
cord-310268-8q4tk6fd	282	15	Lucentis	Lucentis	NNP
cord-310268-8q4tk6fd	282	16	)	)	-RRB-
cord-310268-8q4tk6fd	282	17	for	for	IN
cord-310268-8q4tk6fd	282	18	wet	wet	JJ
cord-310268-8q4tk6fd	282	19	age	age	NN
cord-310268-8q4tk6fd	282	20	-	-	HYPH
cord-310268-8q4tk6fd	282	21	related	relate	VBN
cord-310268-8q4tk6fd	282	22	macular	macular	JJ
cord-310268-8q4tk6fd	282	23	degeneration	degeneration	NN
cord-310268-8q4tk6fd	282	24	treatment	treatment	NN
cord-310268-8q4tk6fd	282	25	is	be	VBZ
cord-310268-8q4tk6fd	282	26	ongoing	ongoing	JJ
cord-310268-8q4tk6fd	282	27	(	(	-LRB-
cord-310268-8q4tk6fd	282	28	NCT01944839	NCT01944839	NNP
cord-310268-8q4tk6fd	282	29	)	)	-RRB-
cord-310268-8q4tk6fd	282	30	.	.	.
cord-310268-8q4tk6fd	283	1	Besides	besides	IN
cord-310268-8q4tk6fd	283	2	the	the	DT
cord-310268-8q4tk6fd	283	3	DNA	dna	NN
cord-310268-8q4tk6fd	283	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	283	5	in	in	IN
cord-310268-8q4tk6fd	283	6	clinical	clinical	JJ
cord-310268-8q4tk6fd	283	7	trials	trial	NNS
cord-310268-8q4tk6fd	283	8	,	,	,
cord-310268-8q4tk6fd	283	9	many	many	JJ
cord-310268-8q4tk6fd	283	10	promising	promising	JJ
cord-310268-8q4tk6fd	283	11	DNA	dna	NN
cord-310268-8q4tk6fd	283	12	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	283	13	are	be	VBP
cord-310268-8q4tk6fd	283	14	in	in	IN
cord-310268-8q4tk6fd	283	15	preclinical	preclinical	JJ
cord-310268-8q4tk6fd	283	16	studies	study	NNS
cord-310268-8q4tk6fd	283	17	for	for	IN
cord-310268-8q4tk6fd	283	18	treating	treat	VBG
cord-310268-8q4tk6fd	283	19	various	various	JJ
cord-310268-8q4tk6fd	283	20	diseases	disease	NNS
cord-310268-8q4tk6fd	283	21	,	,	,
cord-310268-8q4tk6fd	283	22	such	such	JJ
cord-310268-8q4tk6fd	283	23	as	as	IN
cord-310268-8q4tk6fd	283	24	virus	virus	NN
cord-310268-8q4tk6fd	283	25	infections	infection	NNS
cord-310268-8q4tk6fd	283	26	,	,	,
cord-310268-8q4tk6fd	283	27	tumors	tumor	NNS
cord-310268-8q4tk6fd	283	28	and	and	CC
cord-310268-8q4tk6fd	283	29	central	central	JJ
cord-310268-8q4tk6fd	283	30	nervous	nervous	JJ
cord-310268-8q4tk6fd	283	31	system	system	NN
cord-310268-8q4tk6fd	283	32	diseases	disease	NNS
cord-310268-8q4tk6fd	283	33	.	.	.
cord-310268-8q4tk6fd	284	1	A	a	DT
cord-310268-8q4tk6fd	284	2	DNA	DNA	NNP
cord-310268-8q4tk6fd	284	3	aptamer	aptamer	NN
cord-310268-8q4tk6fd	284	4	recognizing	recognize	VBG
cord-310268-8q4tk6fd	284	5	the	the	DT
cord-310268-8q4tk6fd	284	6	receptor	receptor	NN
cord-310268-8q4tk6fd	284	7	-	-	HYPH
cord-310268-8q4tk6fd	284	8	binding	bind	VBG
cord-310268-8q4tk6fd	284	9	region	region	NN
cord-310268-8q4tk6fd	284	10	of	of	IN
cord-310268-8q4tk6fd	284	11	influenza	influenza	NN
cord-310268-8q4tk6fd	284	12	A	a	DT
cord-310268-8q4tk6fd	284	13	hemagglutinin	hemagglutinin	NN
cord-310268-8q4tk6fd	284	14	was	be	VBD
cord-310268-8q4tk6fd	284	15	found	find	VBN
cord-310268-8q4tk6fd	284	16	to	to	TO
cord-310268-8q4tk6fd	284	17	inhibit	inhibit	VB
cord-310268-8q4tk6fd	284	18	viral	viral	JJ
cord-310268-8q4tk6fd	284	19	infection	infection	NN
cord-310268-8q4tk6fd	284	20	in	in	IN
cord-310268-8q4tk6fd	284	21	an	an	DT
cord-310268-8q4tk6fd	284	22	animal	animal	NN
cord-310268-8q4tk6fd	284	23	model	model	NN
cord-310268-8q4tk6fd	284	24	against	against	IN
cord-310268-8q4tk6fd	284	25	different	different	JJ
cord-310268-8q4tk6fd	284	26	influenza	influenza	NN
cord-310268-8q4tk6fd	284	27	strains	strain	NNS
cord-310268-8q4tk6fd	284	28	,	,	,
cord-310268-8q4tk6fd	284	29	as	as	IN
cord-310268-8q4tk6fd	284	30	manifested	manifest	VBN
cord-310268-8q4tk6fd	284	31	by	by	IN
cord-310268-8q4tk6fd	284	32	a	a	DT
cord-310268-8q4tk6fd	284	33	90%-99	90%-99	CD
cord-310268-8q4tk6fd	284	34	%	%	NN
cord-310268-8q4tk6fd	284	35	reduction	reduction	NN
cord-310268-8q4tk6fd	284	36	of	of	IN
cord-310268-8q4tk6fd	284	37	the	the	DT
cord-310268-8q4tk6fd	284	38	virus	virus	NN
cord-310268-8q4tk6fd	284	39	burden	burden	NN
cord-310268-8q4tk6fd	284	40	in	in	IN
cord-310268-8q4tk6fd	284	41	the	the	DT
cord-310268-8q4tk6fd	284	42	lungs	lung	NNS
cord-310268-8q4tk6fd	284	43	of	of	IN
cord-310268-8q4tk6fd	284	44	treated	treat	VBN
cord-310268-8q4tk6fd	284	45	mice	mouse	NNS
cord-310268-8q4tk6fd	284	46	[	[	-LRB-
cord-310268-8q4tk6fd	284	47	100	100	CD
cord-310268-8q4tk6fd	284	48	]	]	-RRB-
cord-310268-8q4tk6fd	284	49	.	.	.
cord-310268-8q4tk6fd	285	1	DNA	DNA	NNP
cord-310268-8q4tk6fd	285	2	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	285	3	NAS-24	NAS-24	NNP
cord-310268-8q4tk6fd	285	4	was	be	VBD
cord-310268-8q4tk6fd	285	5	found	find	VBN
cord-310268-8q4tk6fd	285	6	to	to	TO
cord-310268-8q4tk6fd	285	7	bind	bind	VB
cord-310268-8q4tk6fd	285	8	to	to	IN
cord-310268-8q4tk6fd	285	9	vimentin	vimentin	NNS
cord-310268-8q4tk6fd	285	10	and	and	CC
cord-310268-8q4tk6fd	285	11	then	then	RB
cord-310268-8q4tk6fd	285	12	cause	cause	VB
cord-310268-8q4tk6fd	285	13	apoptosis	apoptosis	NN
cord-310268-8q4tk6fd	285	14	of	of	IN
cord-310268-8q4tk6fd	285	15	mouse	mouse	NN
cord-310268-8q4tk6fd	285	16	ascites	ascites	NN
cord-310268-8q4tk6fd	285	17	adenocarcinoma	adenocarcinoma	NN
cord-310268-8q4tk6fd	285	18	cells	cell	NNS
cord-310268-8q4tk6fd	285	19	in	in	IN
cord-310268-8q4tk6fd	285	20	vitro	vitro	FW
cord-310268-8q4tk6fd	285	21	and	and	CC
cord-310268-8q4tk6fd	285	22	in	in	IN
cord-310268-8q4tk6fd	285	23	vivo	vivo	NNP
cord-310268-8q4tk6fd	285	24	[	[	-LRB-
cord-310268-8q4tk6fd	285	25	101	101	CD
cord-310268-8q4tk6fd	285	26	]	]	-RRB-
cord-310268-8q4tk6fd	285	27	.	.	.
cord-310268-8q4tk6fd	286	1	Recently	recently	RB
cord-310268-8q4tk6fd	286	2	,	,	,
cord-310268-8q4tk6fd	286	3	DNA	DNA	NNP
cord-310268-8q4tk6fd	286	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	286	5	targeting	target	VBG
cord-310268-8q4tk6fd	286	6	human	human	JJ
cord-310268-8q4tk6fd	286	7	epidermal	epidermal	JJ
cord-310268-8q4tk6fd	286	8	growth	growth	NN
cord-310268-8q4tk6fd	286	9	factor	factor	NN
cord-310268-8q4tk6fd	286	10	receptor	receptor	NN
cord-310268-8q4tk6fd	286	11	2	2	CD
cord-310268-8q4tk6fd	287	1	(	(	-LRB-
cord-310268-8q4tk6fd	287	2	ErbB-2	ErbB-2	NNP
cord-310268-8q4tk6fd	287	3	/	/	SYM
cord-310268-8q4tk6fd	287	4	HER2	HER2	NNP
cord-310268-8q4tk6fd	287	5	)	)	-RRB-
cord-310268-8q4tk6fd	287	6	was	be	VBD
cord-310268-8q4tk6fd	287	7	demonstrated	demonstrate	VBN
cord-310268-8q4tk6fd	287	8	to	to	TO
cord-310268-8q4tk6fd	287	9	retard	retard	VB
cord-310268-8q4tk6fd	287	10	the	the	DT
cord-310268-8q4tk6fd	287	11	tumorigenic	tumorigenic	JJ
cord-310268-8q4tk6fd	287	12	growth	growth	NN
cord-310268-8q4tk6fd	287	13	of	of	IN
cord-310268-8q4tk6fd	287	14	gastric	gastric	JJ
cord-310268-8q4tk6fd	287	15	cancer	cancer	NN
cord-310268-8q4tk6fd	287	16	in	in	IN
cord-310268-8q4tk6fd	287	17	mice	mouse	NNS
cord-310268-8q4tk6fd	287	18	with	with	IN
cord-310268-8q4tk6fd	287	19	more	more	JJR
cord-310268-8q4tk6fd	287	20	effective	effective	JJ
cord-310268-8q4tk6fd	287	21	activity	activity	NN
cord-310268-8q4tk6fd	287	22	than	than	IN
cord-310268-8q4tk6fd	287	23	anti	anti	JJ
cord-310268-8q4tk6fd	287	24	-	-	NNP
cord-310268-8q4tk6fd	287	25	ErbB-2	ErbB-2	NNP
cord-310268-8q4tk6fd	287	26	/	/	SYM
cord-310268-8q4tk6fd	287	27	HER2	her2	JJ
cord-310268-8q4tk6fd	287	28	monoclonal	monoclonal	JJ
cord-310268-8q4tk6fd	287	29	antibody	antibody	NN
cord-310268-8q4tk6fd	287	30	[	[	-LRB-
cord-310268-8q4tk6fd	287	31	102	102	CD
cord-310268-8q4tk6fd	287	32	]	]	-RRB-
cord-310268-8q4tk6fd	287	33	.	.	.
cord-310268-8q4tk6fd	288	1	Moreover	moreover	RB
cord-310268-8q4tk6fd	288	2	,	,	,
cord-310268-8q4tk6fd	288	3	remyelination	remyelination	NN
cord-310268-8q4tk6fd	288	4	was	be	VBD
cord-310268-8q4tk6fd	288	5	induced	induce	VBN
cord-310268-8q4tk6fd	288	6	by	by	IN
cord-310268-8q4tk6fd	288	7	a	a	DT
cord-310268-8q4tk6fd	288	8	DNA	DNA	NNP
cord-310268-8q4tk6fd	288	9	aptamer	aptamer	NN
cord-310268-8q4tk6fd	288	10	in	in	IN
cord-310268-8q4tk6fd	288	11	a	a	DT
cord-310268-8q4tk6fd	288	12	mouse	mouse	NN
cord-310268-8q4tk6fd	288	13	model	model	NN
cord-310268-8q4tk6fd	288	14	of	of	IN
cord-310268-8q4tk6fd	288	15	multiple	multiple	JJ
cord-310268-8q4tk6fd	288	16	sclerosis	sclerosis	NN
cord-310268-8q4tk6fd	288	17	(	(	-LRB-
cord-310268-8q4tk6fd	288	18	inflammatory	inflammatory	JJ
cord-310268-8q4tk6fd	288	19	disease	disease	NN
cord-310268-8q4tk6fd	288	20	of	of	IN
cord-310268-8q4tk6fd	288	21	the	the	DT
cord-310268-8q4tk6fd	288	22	central	central	JJ
cord-310268-8q4tk6fd	288	23	nervous	nervous	JJ
cord-310268-8q4tk6fd	288	24	system	system	NN
cord-310268-8q4tk6fd	288	25	)	)	-RRB-
cord-310268-8q4tk6fd	288	26	,	,	,
cord-310268-8q4tk6fd	288	27	which	which	WDT
cord-310268-8q4tk6fd	288	28	highlights	highlight	VBZ
cord-310268-8q4tk6fd	288	29	the	the	DT
cord-310268-8q4tk6fd	288	30	potential	potential	JJ
cord-310268-8q4tk6fd	288	31	therapeutic	therapeutic	JJ
cord-310268-8q4tk6fd	288	32	application	application	NN
cord-310268-8q4tk6fd	288	33	of	of	IN
cord-310268-8q4tk6fd	288	34	DNA	DNA	NNP
cord-310268-8q4tk6fd	288	35	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	288	36	in	in	IN
cord-310268-8q4tk6fd	288	37	the	the	DT
cord-310268-8q4tk6fd	288	38	treatment	treatment	NN
cord-310268-8q4tk6fd	288	39	of	of	IN
cord-310268-8q4tk6fd	288	40	multiple	multiple	JJ
cord-310268-8q4tk6fd	288	41	sclerosis	sclerosis	NN
cord-310268-8q4tk6fd	288	42	[	[	-LRB-
cord-310268-8q4tk6fd	288	43	103	103	CD
cord-310268-8q4tk6fd	288	44	]	]	-RRB-
cord-310268-8q4tk6fd	288	45	.	.	.
cord-310268-8q4tk6fd	289	1	Cell	cell	NN
cord-310268-8q4tk6fd	289	2	-	-	HYPH
cord-310268-8q4tk6fd	289	3	specific	specific	JJ
cord-310268-8q4tk6fd	289	4	drug	drug	NN
cord-310268-8q4tk6fd	289	5	delivery	delivery	NN
cord-310268-8q4tk6fd	289	6	can	can	MD
cord-310268-8q4tk6fd	289	7	help	help	VB
cord-310268-8q4tk6fd	289	8	to	to	TO
cord-310268-8q4tk6fd	289	9	increase	increase	VB
cord-310268-8q4tk6fd	289	10	the	the	DT
cord-310268-8q4tk6fd	289	11	efficiency	efficiency	NN
cord-310268-8q4tk6fd	289	12	of	of	IN
cord-310268-8q4tk6fd	289	13	a	a	DT
cord-310268-8q4tk6fd	289	14	drug	drug	NN
cord-310268-8q4tk6fd	289	15	and	and	CC
cord-310268-8q4tk6fd	289	16	reduce	reduce	VB
cord-310268-8q4tk6fd	289	17	side	side	NN
cord-310268-8q4tk6fd	289	18	effects	effect	NNS
cord-310268-8q4tk6fd	289	19	.	.	.
cord-310268-8q4tk6fd	290	1	In	in	IN
cord-310268-8q4tk6fd	290	2	addition	addition	NN
cord-310268-8q4tk6fd	290	3	to	to	IN
cord-310268-8q4tk6fd	290	4	functioning	function	VBG
cord-310268-8q4tk6fd	290	5	as	as	IN
cord-310268-8q4tk6fd	290	6	therapeutic	therapeutic	JJ
cord-310268-8q4tk6fd	290	7	agents	agent	NNS
cord-310268-8q4tk6fd	290	8	,	,	,
cord-310268-8q4tk6fd	290	9	DNA	DNA	NNP
cord-310268-8q4tk6fd	290	10	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	290	11	have	have	VBP
cord-310268-8q4tk6fd	290	12	also	also	RB
cord-310268-8q4tk6fd	290	13	been	be	VBN
cord-310268-8q4tk6fd	290	14	explored	explore	VBN
cord-310268-8q4tk6fd	290	15	as	as	IN
cord-310268-8q4tk6fd	290	16	delivery	delivery	NN
cord-310268-8q4tk6fd	290	17	vehicles	vehicle	NNS
cord-310268-8q4tk6fd	290	18	in	in	IN
cord-310268-8q4tk6fd	290	19	targeted	target	VBN
cord-310268-8q4tk6fd	290	20	delivery	delivery	NN
cord-310268-8q4tk6fd	290	21	of	of	IN
cord-310268-8q4tk6fd	290	22	drugs	drug	NNS
cord-310268-8q4tk6fd	290	23	or	or	CC
cord-310268-8q4tk6fd	290	24	small	small	JJ
cord-310268-8q4tk6fd	290	25	oligonucleotides	oligonucleotide	NNS
cord-310268-8q4tk6fd	290	26	such	such	JJ
cord-310268-8q4tk6fd	290	27	as	as	IN
cord-310268-8q4tk6fd	290	28	small	small	JJ
cord-310268-8q4tk6fd	290	29	interference	interference	NN
cord-310268-8q4tk6fd	290	30	RNA	RNA	NNP
cord-310268-8q4tk6fd	290	31	(	(	-LRB-
cord-310268-8q4tk6fd	290	32	siRNA	siRNA	NNP
cord-310268-8q4tk6fd	290	33	)	)	-RRB-
cord-310268-8q4tk6fd	290	34	and	and	CC
cord-310268-8q4tk6fd	290	35	microRNA	microRNA	NNP
cord-310268-8q4tk6fd	290	36	(	(	-LRB-
cord-310268-8q4tk6fd	290	37	miRNA	miRNA	NNP
cord-310268-8q4tk6fd	290	38	)	)	-RRB-
cord-310268-8q4tk6fd	290	39	.	.	.
cord-310268-8q4tk6fd	291	1	The	the	DT
cord-310268-8q4tk6fd	291	2	ability	ability	NN
cord-310268-8q4tk6fd	291	3	of	of	IN
cord-310268-8q4tk6fd	291	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	291	5	to	to	TO
cord-310268-8q4tk6fd	291	6	specifically	specifically	RB
cord-310268-8q4tk6fd	291	7	recognize	recognize	VB
cord-310268-8q4tk6fd	291	8	the	the	DT
cord-310268-8q4tk6fd	291	9	target	target	NN
cord-310268-8q4tk6fd	291	10	and	and	CC
cord-310268-8q4tk6fd	291	11	to	to	TO
cord-310268-8q4tk6fd	291	12	be	be	VB
cord-310268-8q4tk6fd	291	13	readily	readily	RB
cord-310268-8q4tk6fd	291	14	modified	modify	VBN
cord-310268-8q4tk6fd	291	15	makes	make	VBZ
cord-310268-8q4tk6fd	291	16	it	-PRON-	PRP
cord-310268-8q4tk6fd	291	17	a	a	DT
cord-310268-8q4tk6fd	291	18	potential	potential	JJ
cord-310268-8q4tk6fd	291	19	targeted	target	VBN
cord-310268-8q4tk6fd	291	20	delivery	delivery	NN
cord-310268-8q4tk6fd	291	21	tool	tool	NN
cord-310268-8q4tk6fd	291	22	.	.	.
cord-310268-8q4tk6fd	292	1	DNA	DNA	NNP
cord-310268-8q4tk6fd	292	2	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	292	3	are	be	VBP
cord-310268-8q4tk6fd	292	4	used	use	VBN
cord-310268-8q4tk6fd	292	5	in	in	IN
cord-310268-8q4tk6fd	292	6	two	two	CD
cord-310268-8q4tk6fd	292	7	ways	way	NNS
cord-310268-8q4tk6fd	292	8	for	for	IN
cord-310268-8q4tk6fd	292	9	targeted	target	VBN
cord-310268-8q4tk6fd	292	10	delivery	delivery	NN
cord-310268-8q4tk6fd	292	11	of	of	IN
cord-310268-8q4tk6fd	292	12	drugs	drug	NNS
cord-310268-8q4tk6fd	292	13	:	:	:
cord-310268-8q4tk6fd	292	14	(	(	-LRB-
cord-310268-8q4tk6fd	292	15	1	1	LS
cord-310268-8q4tk6fd	292	16	)	)	-RRB-
cord-310268-8q4tk6fd	292	17	directly	directly	RB
cord-310268-8q4tk6fd	292	18	linked	link	VBN
cord-310268-8q4tk6fd	292	19	to	to	IN
cord-310268-8q4tk6fd	292	20	the	the	DT
cord-310268-8q4tk6fd	292	21	drug	drug	NN
cord-310268-8q4tk6fd	292	22	molecules	molecule	NNS
cord-310268-8q4tk6fd	292	23	;	;	,
cord-310268-8q4tk6fd	292	24	(	(	-LRB-
cord-310268-8q4tk6fd	292	25	2	2	LS
cord-310268-8q4tk6fd	292	26	)	)	-RRB-
cord-310268-8q4tk6fd	292	27	in	in	IN
cord-310268-8q4tk6fd	292	28	combination	combination	NN
cord-310268-8q4tk6fd	292	29	with	with	IN
cord-310268-8q4tk6fd	292	30	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	292	31	to	to	TO
cord-310268-8q4tk6fd	292	32	form	form	VB
cord-310268-8q4tk6fd	292	33	the	the	DT
cord-310268-8q4tk6fd	292	34	delivery	delivery	NN
cord-310268-8q4tk6fd	292	35	platform	platform	NN
cord-310268-8q4tk6fd	292	36	.	.	.
cord-310268-8q4tk6fd	293	1	Conjugating	conjugate	VBG
cord-310268-8q4tk6fd	293	2	drug	drug	NN
cord-310268-8q4tk6fd	293	3	molecules	molecule	NNS
cord-310268-8q4tk6fd	293	4	directly	directly	RB
cord-310268-8q4tk6fd	293	5	to	to	IN
cord-310268-8q4tk6fd	293	6	specific	specific	JJ
cord-310268-8q4tk6fd	293	7	DNA	DNA	NNP
cord-310268-8q4tk6fd	293	8	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	293	9	is	be	VBZ
cord-310268-8q4tk6fd	293	10	a	a	DT
cord-310268-8q4tk6fd	293	11	potential	potential	JJ
cord-310268-8q4tk6fd	293	12	way	way	NN
cord-310268-8q4tk6fd	293	13	to	to	TO
cord-310268-8q4tk6fd	293	14	deliver	deliver	VB
cord-310268-8q4tk6fd	293	15	the	the	DT
cord-310268-8q4tk6fd	293	16	drugs	drug	NNS
cord-310268-8q4tk6fd	293	17	specifically	specifically	RB
cord-310268-8q4tk6fd	293	18	,	,	,
cord-310268-8q4tk6fd	293	19	and	and	CC
cord-310268-8q4tk6fd	293	20	thus	thus	RB
cord-310268-8q4tk6fd	293	21	reduce	reduce	VB
cord-310268-8q4tk6fd	293	22	the	the	DT
cord-310268-8q4tk6fd	293	23	risk	risk	NN
cord-310268-8q4tk6fd	293	24	of	of	IN
cord-310268-8q4tk6fd	293	25	off	off	IN
cord-310268-8q4tk6fd	293	26	-	-	HYPH
cord-310268-8q4tk6fd	293	27	target	target	NN
cord-310268-8q4tk6fd	293	28	drugs	drug	NNS
cord-310268-8q4tk6fd	293	29	.	.	.
cord-310268-8q4tk6fd	294	1	By	by	IN
cord-310268-8q4tk6fd	294	2	linking	link	VBG
cord-310268-8q4tk6fd	294	3	DNA	dna	NN
cord-310268-8q4tk6fd	294	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	294	5	to	to	IN
cord-310268-8q4tk6fd	294	6	drugs	drug	NNS
cord-310268-8q4tk6fd	294	7	or	or	CC
cord-310268-8q4tk6fd	294	8	packing	pack	VBG
cord-310268-8q4tk6fd	294	9	the	the	DT
cord-310268-8q4tk6fd	294	10	drug	drug	NN
cord-310268-8q4tk6fd	294	11	into	into	IN
cord-310268-8q4tk6fd	294	12	an	an	DT
cord-310268-8q4tk6fd	294	13	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	294	14	-	-	HYPH
cord-310268-8q4tk6fd	294	15	folded	fold	VBN
cord-310268-8q4tk6fd	294	16	structure	structure	NN
cord-310268-8q4tk6fd	294	17	,	,	,
cord-310268-8q4tk6fd	294	18	DNA	DNA	NNP
cord-310268-8q4tk6fd	294	19	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	294	20	-	-	HYPH
cord-310268-8q4tk6fd	294	21	drug	drug	NN
cord-310268-8q4tk6fd	294	22	conjugates	conjugate	NNS
cord-310268-8q4tk6fd	294	23	can	can	MD
cord-310268-8q4tk6fd	294	24	efficiently	efficiently	RB
cord-310268-8q4tk6fd	294	25	deliver	deliver	VB
cord-310268-8q4tk6fd	294	26	drugs	drug	NNS
cord-310268-8q4tk6fd	294	27	to	to	TO
cord-310268-8q4tk6fd	294	28	target	target	VB
cord-310268-8q4tk6fd	294	29	cells	cell	NNS
cord-310268-8q4tk6fd	294	30	with	with	IN
cord-310268-8q4tk6fd	294	31	increased	increase	VBN
cord-310268-8q4tk6fd	294	32	specificity	specificity	NN
cord-310268-8q4tk6fd	294	33	.	.	.
cord-310268-8q4tk6fd	295	1	Many	many	JJ
cord-310268-8q4tk6fd	295	2	DNA	dna	NN
cord-310268-8q4tk6fd	295	3	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	295	4	have	have	VBP
cord-310268-8q4tk6fd	295	5	been	be	VBN
cord-310268-8q4tk6fd	295	6	selected	select	VBN
cord-310268-8q4tk6fd	295	7	to	to	TO
cord-310268-8q4tk6fd	295	8	efficiently	efficiently	RB
cord-310268-8q4tk6fd	295	9	deliver	deliver	VB
cord-310268-8q4tk6fd	295	10	chemotherapy	chemotherapy	NN
cord-310268-8q4tk6fd	295	11	drugs	drug	NNS
cord-310268-8q4tk6fd	295	12	in	in	IN
cord-310268-8q4tk6fd	295	13	vitro	vitro	FW
cord-310268-8q4tk6fd	295	14	or	or	CC
cord-310268-8q4tk6fd	295	15	in	in	IN
cord-310268-8q4tk6fd	295	16	vivo	vivo	NN
cord-310268-8q4tk6fd	295	17	,	,	,
cord-310268-8q4tk6fd	295	18	such	such	JJ
cord-310268-8q4tk6fd	295	19	as	as	IN
cord-310268-8q4tk6fd	295	20	doxorubicin	doxorubicin	NN
cord-310268-8q4tk6fd	295	21	(	(	-LRB-
cord-310268-8q4tk6fd	295	22	DOX	DOX	NNP
cord-310268-8q4tk6fd	295	23	)	)	-RRB-
cord-310268-8q4tk6fd	295	24	[	[	-LRB-
cord-310268-8q4tk6fd	295	25	104	104	CD
cord-310268-8q4tk6fd	295	26	]	]	-RRB-
cord-310268-8q4tk6fd	295	27	,	,	,
cord-310268-8q4tk6fd	295	28	fluorouracil	fluorouracil	NN
cord-310268-8q4tk6fd	295	29	[	[	-LRB-
cord-310268-8q4tk6fd	295	30	105	105	CD
cord-310268-8q4tk6fd	295	31	]	]	-RRB-
cord-310268-8q4tk6fd	295	32	and	and	CC
cord-310268-8q4tk6fd	295	33	epirubicin	epirubicin	VB
cord-310268-8q4tk6fd	295	34	[	[	-LRB-
cord-310268-8q4tk6fd	295	35	106	106	CD
cord-310268-8q4tk6fd	295	36	]	]	-RRB-
cord-310268-8q4tk6fd	295	37	.	.	.
cord-310268-8q4tk6fd	296	1	Dimeric	dimeric	JJ
cord-310268-8q4tk6fd	296	2	or	or	CC
cord-310268-8q4tk6fd	296	3	dendrimer	dendrimer	NNP
cord-310268-8q4tk6fd	296	4	DNA	DNA	NNP
cord-310268-8q4tk6fd	296	5	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	296	6	in	in	IN
cord-310268-8q4tk6fd	296	7	conjugation	conjugation	NN
cord-310268-8q4tk6fd	296	8	with	with	IN
cord-310268-8q4tk6fd	296	9	drugs	drug	NNS
cord-310268-8q4tk6fd	296	10	have	have	VBP
cord-310268-8q4tk6fd	296	11	been	be	VBN
cord-310268-8q4tk6fd	296	12	developed	develop	VBN
cord-310268-8q4tk6fd	296	13	to	to	TO
cord-310268-8q4tk6fd	296	14	further	further	RB
cord-310268-8q4tk6fd	296	15	enhance	enhance	VB
cord-310268-8q4tk6fd	296	16	the	the	DT
cord-310268-8q4tk6fd	296	17	efficiency	efficiency	NN
cord-310268-8q4tk6fd	296	18	of	of	IN
cord-310268-8q4tk6fd	296	19	target	target	NN
cord-310268-8q4tk6fd	296	20	delivery	delivery	NN
cord-310268-8q4tk6fd	296	21	[	[	-LRB-
cord-310268-8q4tk6fd	296	22	107	107	CD
cord-310268-8q4tk6fd	296	23	,	,	,
cord-310268-8q4tk6fd	296	24	108	108	CD
cord-310268-8q4tk6fd	296	25	]	]	-RRB-
cord-310268-8q4tk6fd	296	26	.	.	.
cord-310268-8q4tk6fd	297	1	With	with	IN
cord-310268-8q4tk6fd	297	2	regard	regard	NN
cord-310268-8q4tk6fd	297	3	to	to	IN
cord-310268-8q4tk6fd	297	4	small	small	JJ
cord-310268-8q4tk6fd	297	5	oligonucleotides	oligonucleotide	NNS
cord-310268-8q4tk6fd	297	6	delivery	delivery	NN
cord-310268-8q4tk6fd	297	7	,	,	,
cord-310268-8q4tk6fd	297	8	DNA	DNA	NNP
cord-310268-8q4tk6fd	297	9	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	297	10	were	be	VBD
cord-310268-8q4tk6fd	297	11	directly	directly	RB
cord-310268-8q4tk6fd	297	12	linked	link	VBN
cord-310268-8q4tk6fd	297	13	to	to	IN
cord-310268-8q4tk6fd	297	14	the	the	DT
cord-310268-8q4tk6fd	297	15	small	small	JJ
cord-310268-8q4tk6fd	297	16	oligonucleotides	oligonucleotide	NNS
cord-310268-8q4tk6fd	297	17	to	to	TO
cord-310268-8q4tk6fd	297	18	form	form	VB
cord-310268-8q4tk6fd	297	19	a	a	DT
cord-310268-8q4tk6fd	297	20	DNA	DNA	NNP
cord-310268-8q4tk6fd	297	21	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	297	22	-	-	HYPH
cord-310268-8q4tk6fd	297	23	oligonucleotide	oligonucleotide	JJ
cord-310268-8q4tk6fd	297	24	chimera	chimera	NN
cord-310268-8q4tk6fd	297	25	,	,	,
cord-310268-8q4tk6fd	297	26	which	which	WDT
cord-310268-8q4tk6fd	297	27	could	could	MD
cord-310268-8q4tk6fd	297	28	help	help	VB
cord-310268-8q4tk6fd	297	29	to	to	TO
cord-310268-8q4tk6fd	297	30	prevent	prevent	VB
cord-310268-8q4tk6fd	297	31	non	non	JJ
cord-310268-8q4tk6fd	297	32	-	-	JJ
cord-310268-8q4tk6fd	297	33	specific	specific	JJ
cord-310268-8q4tk6fd	297	34	internalization	internalization	NN
cord-310268-8q4tk6fd	297	35	as	as	RB
cord-310268-8q4tk6fd	297	36	well	well	RB
cord-310268-8q4tk6fd	297	37	as	as	IN
cord-310268-8q4tk6fd	297	38	decrease	decrease	VB
cord-310268-8q4tk6fd	297	39	the	the	DT
cord-310268-8q4tk6fd	297	40	cellular	cellular	JJ
cord-310268-8q4tk6fd	297	41	toxicity	toxicity	NN
cord-310268-8q4tk6fd	297	42	towards	towards	IN
cord-310268-8q4tk6fd	297	43	non	non	JJ
cord-310268-8q4tk6fd	297	44	-	-	JJ
cord-310268-8q4tk6fd	297	45	target	target	JJ
cord-310268-8q4tk6fd	297	46	cells	cell	NNS
cord-310268-8q4tk6fd	297	47	.	.	.
cord-310268-8q4tk6fd	298	1	We	-PRON-	PRP
cord-310268-8q4tk6fd	298	2	have	have	VBP
cord-310268-8q4tk6fd	298	3	reported	report	VBN
cord-310268-8q4tk6fd	298	4	that	that	IN
cord-310268-8q4tk6fd	298	5	a	a	DT
cord-310268-8q4tk6fd	298	6	DNA	DNA	NNP
cord-310268-8q4tk6fd	298	7	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	298	8	-	-	HYPH
cord-310268-8q4tk6fd	298	9	siRNA	siRNA	NNP
cord-310268-8q4tk6fd	298	10	chimera	chimera	NN
cord-310268-8q4tk6fd	298	11	could	could	MD
cord-310268-8q4tk6fd	298	12	specifically	specifically	RB
cord-310268-8q4tk6fd	298	13	enter	enter	VB
cord-310268-8q4tk6fd	298	14	into	into	IN
cord-310268-8q4tk6fd	298	15	CD4	CD4	NNP
cord-310268-8q4tk6fd	298	16	(	(	-LRB-
cord-310268-8q4tk6fd	298	17	+	+	NNS
cord-310268-8q4tk6fd	298	18	)	)	-RRB-
cord-310268-8q4tk6fd	298	19	T	t	NN
cord-310268-8q4tk6fd	298	20	cells	cell	NNS
cord-310268-8q4tk6fd	298	21	and	and	CC
cord-310268-8q4tk6fd	298	22	efficiently	efficiently	RB
cord-310268-8q4tk6fd	298	23	decrease	decrease	VB
cord-310268-8q4tk6fd	298	24	the	the	DT
cord-310268-8q4tk6fd	298	25	expression	expression	NN
cord-310268-8q4tk6fd	298	26	of	of	IN
cord-310268-8q4tk6fd	298	27	exogenous	exogenous	JJ
cord-310268-8q4tk6fd	298	28	the	the	DT
cord-310268-8q4tk6fd	298	29	HIV	HIV	NNP
cord-310268-8q4tk6fd	298	30	protease	protease	NN
cord-310268-8q4tk6fd	298	31	gene	gene	NN
cord-310268-8q4tk6fd	298	32	[	[	-LRB-
cord-310268-8q4tk6fd	298	33	18	18	CD
cord-310268-8q4tk6fd	298	34	]	]	-RRB-
cord-310268-8q4tk6fd	298	35	.	.	.
cord-310268-8q4tk6fd	299	1	An	an	DT
cord-310268-8q4tk6fd	299	2	anti	anti	JJ
cord-310268-8q4tk6fd	299	3	-	-	JJ
cord-310268-8q4tk6fd	299	4	mucin	mucin	JJ
cord-310268-8q4tk6fd	299	5	1	1	CD
cord-310268-8q4tk6fd	299	6	DNA	DNA	NNP
cord-310268-8q4tk6fd	299	7	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	299	8	covalently	covalently	RB
cord-310268-8q4tk6fd	299	9	linked	link	VBN
cord-310268-8q4tk6fd	299	10	to	to	IN
cord-310268-8q4tk6fd	299	11	miRNA-29b	miRNA-29b	NNP
cord-310268-8q4tk6fd	299	12	was	be	VBD
cord-310268-8q4tk6fd	299	13	found	find	VBN
cord-310268-8q4tk6fd	299	14	to	to	TO
cord-310268-8q4tk6fd	299	15	deliver	deliver	VB
cord-310268-8q4tk6fd	299	16	miRNA-29b	miRNA-29b	NNP
cord-310268-8q4tk6fd	299	17	into	into	IN
cord-310268-8q4tk6fd	299	18	ovarian	ovarian	JJ
cord-310268-8q4tk6fd	299	19	cancer	cancer	NN
cord-310268-8q4tk6fd	299	20	cells	cell	NNS
cord-310268-8q4tk6fd	299	21	specifically	specifically	RB
cord-310268-8q4tk6fd	299	22	and	and	CC
cord-310268-8q4tk6fd	299	23	induce	induce	VB
cord-310268-8q4tk6fd	299	24	significant	significant	JJ
cord-310268-8q4tk6fd	299	25	apoptosis	apoptosis	NN
cord-310268-8q4tk6fd	299	26	of	of	IN
cord-310268-8q4tk6fd	299	27	the	the	DT
cord-310268-8q4tk6fd	299	28	cancer	cancer	NN
cord-310268-8q4tk6fd	299	29	cells	cell	NNS
cord-310268-8q4tk6fd	299	30	[	[	-LRB-
cord-310268-8q4tk6fd	299	31	109	109	CD
cord-310268-8q4tk6fd	299	32	]	]	-RRB-
cord-310268-8q4tk6fd	299	33	.	.	.
cord-310268-8q4tk6fd	300	1	DNA	DNA	NNP
cord-310268-8q4tk6fd	300	2	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	300	3	in	in	IN
cord-310268-8q4tk6fd	300	4	combination	combination	NN
cord-310268-8q4tk6fd	300	5	with	with	IN
cord-310268-8q4tk6fd	300	6	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	300	7	as	as	IN
cord-310268-8q4tk6fd	300	8	a	a	DT
cord-310268-8q4tk6fd	300	9	delivery	delivery	NN
cord-310268-8q4tk6fd	300	10	vehicle	vehicle	NN
cord-310268-8q4tk6fd	300	11	is	be	VBZ
cord-310268-8q4tk6fd	300	12	another	another	DT
cord-310268-8q4tk6fd	300	13	promising	promising	JJ
cord-310268-8q4tk6fd	300	14	targeted	target	VBN
cord-310268-8q4tk6fd	300	15	delivery	delivery	NN
cord-310268-8q4tk6fd	300	16	approach	approach	NN
cord-310268-8q4tk6fd	300	17	.	.	.
cord-310268-8q4tk6fd	301	1	A	a	DT
cord-310268-8q4tk6fd	301	2	number	number	NN
cord-310268-8q4tk6fd	301	3	of	of	IN
cord-310268-8q4tk6fd	301	4	nanomaterials	nanomaterial	NNS
cord-310268-8q4tk6fd	301	5	have	have	VBP
cord-310268-8q4tk6fd	301	6	been	be	VBN
cord-310268-8q4tk6fd	301	7	explored	explore	VBN
cord-310268-8q4tk6fd	301	8	to	to	TO
cord-310268-8q4tk6fd	301	9	conjugate	conjugate	VB
cord-310268-8q4tk6fd	301	10	with	with	IN
cord-310268-8q4tk6fd	301	11	DNA	DNA	NNP
cord-310268-8q4tk6fd	301	12	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	301	13	to	to	TO
cord-310268-8q4tk6fd	301	14	form	form	VB
cord-310268-8q4tk6fd	301	15	the	the	DT
cord-310268-8q4tk6fd	301	16	delivery	delivery	NN
cord-310268-8q4tk6fd	301	17	platform	platform	NN
cord-310268-8q4tk6fd	301	18	[	[	-LRB-
cord-310268-8q4tk6fd	301	19	110	110	CD
cord-310268-8q4tk6fd	301	20	,	,	,
cord-310268-8q4tk6fd	301	21	111	111	CD
cord-310268-8q4tk6fd	301	22	]	]	-RRB-
cord-310268-8q4tk6fd	301	23	.	.	.
cord-310268-8q4tk6fd	302	1	DNA	DNA	NNP
cord-310268-8q4tk6fd	302	2	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	302	3	conjugated	conjugate	VBN
cord-310268-8q4tk6fd	302	4	liposome	liposome	NN
cord-310268-8q4tk6fd	302	5	likely	likely	RB
cord-310268-8q4tk6fd	302	6	has	have	VBZ
cord-310268-8q4tk6fd	302	7	the	the	DT
cord-310268-8q4tk6fd	302	8	highest	high	JJS
cord-310268-8q4tk6fd	302	9	potential	potential	NN
cord-310268-8q4tk6fd	302	10	as	as	IN
cord-310268-8q4tk6fd	302	11	a	a	DT
cord-310268-8q4tk6fd	302	12	delivery	delivery	NN
cord-310268-8q4tk6fd	302	13	system	system	NN
cord-310268-8q4tk6fd	302	14	,	,	,
cord-310268-8q4tk6fd	302	15	and	and	CC
cord-310268-8q4tk6fd	302	16	liposome	liposome	NN
cord-310268-8q4tk6fd	302	17	-	-	HYPH
cord-310268-8q4tk6fd	302	18	based	base	VBN
cord-310268-8q4tk6fd	302	19	drug	drug	NN
cord-310268-8q4tk6fd	302	20	delivery	delivery	NN
cord-310268-8q4tk6fd	302	21	systems	system	NNS
cord-310268-8q4tk6fd	302	22	have	have	VBP
cord-310268-8q4tk6fd	302	23	been	be	VBN
cord-310268-8q4tk6fd	302	24	evaluated	evaluate	VBN
cord-310268-8q4tk6fd	302	25	in	in	IN
cord-310268-8q4tk6fd	302	26	clinical	clinical	JJ
cord-310268-8q4tk6fd	302	27	trials	trial	NNS
cord-310268-8q4tk6fd	302	28	.	.	.
cord-310268-8q4tk6fd	303	1	For	for	IN
cord-310268-8q4tk6fd	303	2	example	example	NN
cord-310268-8q4tk6fd	303	3	,	,	,
cord-310268-8q4tk6fd	303	4	AS1411	AS1411	NNP
cord-310268-8q4tk6fd	303	5	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	303	6	conjugated	conjugated	JJ
cord-310268-8q4tk6fd	303	7	liposome	liposome	NN
cord-310268-8q4tk6fd	303	8	was	be	VBD
cord-310268-8q4tk6fd	303	9	found	find	VBN
cord-310268-8q4tk6fd	303	10	be	be	VB
cord-310268-8q4tk6fd	303	11	able	able	JJ
cord-310268-8q4tk6fd	303	12	to	to	TO
cord-310268-8q4tk6fd	303	13	enhance	enhance	VB
cord-310268-8q4tk6fd	303	14	the	the	DT
cord-310268-8q4tk6fd	303	15	delivery	delivery	NN
cord-310268-8q4tk6fd	303	16	specificity	specificity	NN
cord-310268-8q4tk6fd	303	17	and	and	CC
cord-310268-8q4tk6fd	303	18	uptake	uptake	NN
cord-310268-8q4tk6fd	303	19	of	of	IN
cord-310268-8q4tk6fd	303	20	DOX	DOX	NNP
cord-310268-8q4tk6fd	303	21	in	in	IN
cord-310268-8q4tk6fd	303	22	tumor	tumor	NN
cord-310268-8q4tk6fd	303	23	cells	cell	NNS
cord-310268-8q4tk6fd	303	24	,	,	,
cord-310268-8q4tk6fd	303	25	as	as	RB
cord-310268-8q4tk6fd	303	26	well	well	RB
cord-310268-8q4tk6fd	303	27	as	as	IN
cord-310268-8q4tk6fd	303	28	to	to	TO
cord-310268-8q4tk6fd	303	29	increase	increase	VB
cord-310268-8q4tk6fd	303	30	the	the	DT
cord-310268-8q4tk6fd	303	31	accumulation	accumulation	NN
cord-310268-8q4tk6fd	303	32	of	of	IN
cord-310268-8q4tk6fd	303	33	DOX	DOX	NNP
cord-310268-8q4tk6fd	303	34	in	in	IN
cord-310268-8q4tk6fd	303	35	the	the	DT
cord-310268-8q4tk6fd	303	36	tumor	tumor	NN
cord-310268-8q4tk6fd	303	37	tissues	tissue	NNS
cord-310268-8q4tk6fd	303	38	with	with	IN
cord-310268-8q4tk6fd	303	39	reduced	reduce	VBN
cord-310268-8q4tk6fd	303	40	cardiotoxicity	cardiotoxicity	NN
cord-310268-8q4tk6fd	303	41	in	in	IN
cord-310268-8q4tk6fd	303	42	vivo	vivo	NNP
cord-310268-8q4tk6fd	303	43	[	[	-LRB-
cord-310268-8q4tk6fd	303	44	112	112	CD
cord-310268-8q4tk6fd	303	45	]	]	-RRB-
cord-310268-8q4tk6fd	303	46	.	.	.
cord-310268-8q4tk6fd	304	1	Micelles	Micelles	NNP
cord-310268-8q4tk6fd	304	2	,	,	,
cord-310268-8q4tk6fd	304	3	aggregation	aggregation	NN
cord-310268-8q4tk6fd	304	4	of	of	IN
cord-310268-8q4tk6fd	304	5	lipid	lipid	NN
cord-310268-8q4tk6fd	304	6	molecules	molecule	NNS
cord-310268-8q4tk6fd	304	7	,	,	,
cord-310268-8q4tk6fd	304	8	are	be	VBP
cord-310268-8q4tk6fd	304	9	also	also	RB
cord-310268-8q4tk6fd	304	10	used	use	VBN
cord-310268-8q4tk6fd	304	11	in	in	IN
cord-310268-8q4tk6fd	304	12	DNA	DNA	NNP
cord-310268-8q4tk6fd	304	13	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	304	14	-	-	HYPH
cord-310268-8q4tk6fd	304	15	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	304	16	delivery	delivery	NN
cord-310268-8q4tk6fd	304	17	systems	system	NNS
cord-310268-8q4tk6fd	304	18	.	.	.
cord-310268-8q4tk6fd	305	1	Recently	recently	RB
cord-310268-8q4tk6fd	305	2	,	,	,
cord-310268-8q4tk6fd	305	3	AS1411	AS1411	NNP
cord-310268-8q4tk6fd	305	4	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	305	5	conjugated	conjugate	VBD
cord-310268-8q4tk6fd	305	6	PEG	peg	NN
cord-310268-8q4tk6fd	305	7	-	-	HYPH
cord-310268-8q4tk6fd	305	8	poly(lactic	poly(lactic	JJ
cord-310268-8q4tk6fd	305	9	-	-	HYPH
cord-310268-8q4tk6fd	305	10	co	co	NN
cord-310268-8q4tk6fd	305	11	-	-	JJ
cord-310268-8q4tk6fd	305	12	glycolic	glycolic	JJ
cord-310268-8q4tk6fd	305	13	acid	acid	NN
cord-310268-8q4tk6fd	305	14	)	)	-RRB-
cord-310268-8q4tk6fd	305	15	(	(	-LRB-
cord-310268-8q4tk6fd	305	16	PLGA	PLGA	NNP
cord-310268-8q4tk6fd	305	17	)	)	-RRB-
cord-310268-8q4tk6fd	305	18	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	305	19	have	have	VBP
cord-310268-8q4tk6fd	305	20	been	be	VBN
cord-310268-8q4tk6fd	305	21	developed	develop	VBN
cord-310268-8q4tk6fd	305	22	to	to	TO
cord-310268-8q4tk6fd	305	23	facilitate	facilitate	VB
cord-310268-8q4tk6fd	305	24	antiglioma	antiglioma	NNP
cord-310268-8q4tk6fd	305	25	delivery	delivery	NN
cord-310268-8q4tk6fd	305	26	of	of	IN
cord-310268-8q4tk6fd	305	27	paclitaxel	paclitaxel	NNP
cord-310268-8q4tk6fd	305	28	in	in	IN
cord-310268-8q4tk6fd	305	29	vivo	vivo	NNP
cord-310268-8q4tk6fd	305	30	[	[	-LRB-
cord-310268-8q4tk6fd	305	31	49	49	CD
cord-310268-8q4tk6fd	305	32	]	]	-RRB-
cord-310268-8q4tk6fd	305	33	.	.	.
cord-310268-8q4tk6fd	306	1	This	this	DT
cord-310268-8q4tk6fd	306	2	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	306	3	-	-	HYPH
cord-310268-8q4tk6fd	306	4	PEG	PEG	NNP
cord-310268-8q4tk6fd	306	5	-	-	HYPH
cord-310268-8q4tk6fd	306	6	PLGA	PLGA	NNP
cord-310268-8q4tk6fd	306	7	delivery	delivery	NN
cord-310268-8q4tk6fd	306	8	system	system	NN
cord-310268-8q4tk6fd	306	9	can	can	MD
cord-310268-8q4tk6fd	306	10	prolong	prolong	VB
cord-310268-8q4tk6fd	306	11	circulation	circulation	NN
cord-310268-8q4tk6fd	306	12	time	time	NN
cord-310268-8q4tk6fd	306	13	and	and	CC
cord-310268-8q4tk6fd	306	14	enhance	enhance	VB
cord-310268-8q4tk6fd	306	15	target	target	NN
cord-310268-8q4tk6fd	306	16	accumulation	accumulation	NN
cord-310268-8q4tk6fd	306	17	of	of	IN
cord-310268-8q4tk6fd	306	18	paclitaxel	paclitaxel	NN
cord-310268-8q4tk6fd	306	19	,	,	,
cord-310268-8q4tk6fd	306	20	which	which	WDT
cord-310268-8q4tk6fd	306	21	facilitates	facilitate	VBZ
cord-310268-8q4tk6fd	306	22	tumor	tumor	NN
cord-310268-8q4tk6fd	306	23	inhibition	inhibition	NN
cord-310268-8q4tk6fd	306	24	.	.	.
cord-310268-8q4tk6fd	307	1	Gold	gold	NN
cord-310268-8q4tk6fd	307	2	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	307	3	are	be	VBP
cord-310268-8q4tk6fd	307	4	another	another	DT
cord-310268-8q4tk6fd	307	5	attractive	attractive	JJ
cord-310268-8q4tk6fd	307	6	material	material	NN
cord-310268-8q4tk6fd	307	7	used	use	VBN
cord-310268-8q4tk6fd	307	8	in	in	IN
cord-310268-8q4tk6fd	307	9	drug	drug	NN
cord-310268-8q4tk6fd	307	10	delivery	delivery	NN
cord-310268-8q4tk6fd	307	11	system	system	NN
cord-310268-8q4tk6fd	307	12	,	,	,
cord-310268-8q4tk6fd	307	13	because	because	IN
cord-310268-8q4tk6fd	307	14	of	of	IN
cord-310268-8q4tk6fd	307	15	their	-PRON-	PRP$
cord-310268-8q4tk6fd	307	16	high	high	JJ
cord-310268-8q4tk6fd	307	17	stability	stability	NN
cord-310268-8q4tk6fd	307	18	,	,	,
cord-310268-8q4tk6fd	307	19	low	low	JJ
cord-310268-8q4tk6fd	307	20	or	or	CC
cord-310268-8q4tk6fd	307	21	no	no	DT
cord-310268-8q4tk6fd	307	22	toxicity	toxicity	NN
cord-310268-8q4tk6fd	307	23	and	and	CC
cord-310268-8q4tk6fd	307	24	facile	facile	JJ
cord-310268-8q4tk6fd	307	25	conjugation	conjugation	NN
cord-310268-8q4tk6fd	307	26	.	.	.
cord-310268-8q4tk6fd	308	1	A	a	DT
cord-310268-8q4tk6fd	308	2	DNA	dna	NN
cord-310268-8q4tk6fd	308	3	aptamer	aptamer	NN
cord-310268-8q4tk6fd	308	4	(	(	-LRB-
cord-310268-8q4tk6fd	308	5	sgc8c	sgc8c	NN
cord-310268-8q4tk6fd	308	6	)	)	-RRB-
cord-310268-8q4tk6fd	308	7	conjugated	conjugate	VBN
cord-310268-8q4tk6fd	308	8	gold	gold	NN
cord-310268-8q4tk6fd	308	9	nanoparticle	nanoparticle	NN
cord-310268-8q4tk6fd	308	10	system	system	NN
cord-310268-8q4tk6fd	308	11	has	have	VBZ
cord-310268-8q4tk6fd	308	12	been	be	VBN
cord-310268-8q4tk6fd	308	13	found	find	VBN
cord-310268-8q4tk6fd	308	14	to	to	TO
cord-310268-8q4tk6fd	308	15	increase	increase	VB
cord-310268-8q4tk6fd	308	16	the	the	DT
cord-310268-8q4tk6fd	308	17	uptake	uptake	NN
cord-310268-8q4tk6fd	308	18	of	of	IN
cord-310268-8q4tk6fd	308	19	DOX	DOX	NNP
cord-310268-8q4tk6fd	308	20	into	into	IN
cord-310268-8q4tk6fd	308	21	cancer	cancer	NN
cord-310268-8q4tk6fd	308	22	cells	cell	NNS
cord-310268-8q4tk6fd	308	23	[	[	-LRB-
cord-310268-8q4tk6fd	308	24	113	113	CD
cord-310268-8q4tk6fd	308	25	]	]	-RRB-
cord-310268-8q4tk6fd	308	26	.	.	.
cord-310268-8q4tk6fd	309	1	Other	other	JJ
cord-310268-8q4tk6fd	309	2	nanomaterials	nanomaterial	NNS
cord-310268-8q4tk6fd	309	3	such	such	JJ
cord-310268-8q4tk6fd	309	4	as	as	IN
cord-310268-8q4tk6fd	309	5	silica	silica	NN
cord-310268-8q4tk6fd	309	6	,	,	,
cord-310268-8q4tk6fd	309	7	carbon	carbon	NN
cord-310268-8q4tk6fd	309	8	nanotubes	nanotube	NNS
cord-310268-8q4tk6fd	309	9	and	and	CC
cord-310268-8q4tk6fd	309	10	quantum	quantum	NN
cord-310268-8q4tk6fd	309	11	dots	dot	NNS
cord-310268-8q4tk6fd	309	12	have	have	VBP
cord-310268-8q4tk6fd	309	13	also	also	RB
cord-310268-8q4tk6fd	309	14	been	be	VBN
cord-310268-8q4tk6fd	309	15	used	use	VBN
cord-310268-8q4tk6fd	309	16	in	in	IN
cord-310268-8q4tk6fd	309	17	DNA	DNA	NNP
cord-310268-8q4tk6fd	309	18	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	309	19	-	-	HYPH
cord-310268-8q4tk6fd	309	20	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	309	21	delivery	delivery	NN
cord-310268-8q4tk6fd	309	22	systems	system	NNS
cord-310268-8q4tk6fd	309	23	to	to	TO
cord-310268-8q4tk6fd	309	24	enhance	enhance	VB
cord-310268-8q4tk6fd	309	25	the	the	DT
cord-310268-8q4tk6fd	309	26	specificity	specificity	NN
cord-310268-8q4tk6fd	309	27	and	and	CC
cord-310268-8q4tk6fd	309	28	prolong	prolong	VB
cord-310268-8q4tk6fd	309	29	the	the	DT
cord-310268-8q4tk6fd	309	30	circulation	circulation	NN
cord-310268-8q4tk6fd	309	31	of	of	IN
cord-310268-8q4tk6fd	309	32	drug	drug	NN
cord-310268-8q4tk6fd	309	33	molecules	molecule	NNS
cord-310268-8q4tk6fd	309	34	[	[	-LRB-
cord-310268-8q4tk6fd	309	35	114	114	CD
cord-310268-8q4tk6fd	309	36	]	]	-RRB-
cord-310268-8q4tk6fd	309	37	.	.	.
cord-310268-8q4tk6fd	310	1	By	by	IN
cord-310268-8q4tk6fd	310	2	summarizing	summarize	VBG
cord-310268-8q4tk6fd	310	3	the	the	DT
cord-310268-8q4tk6fd	310	4	progress	progress	NN
cord-310268-8q4tk6fd	310	5	of	of	IN
cord-310268-8q4tk6fd	310	6	the	the	DT
cord-310268-8q4tk6fd	310	7	generation	generation	NN
cord-310268-8q4tk6fd	310	8	of	of	IN
cord-310268-8q4tk6fd	310	9	DNA	dna	NN
cord-310268-8q4tk6fd	310	10	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	310	11	and	and	CC
cord-310268-8q4tk6fd	310	12	their	-PRON-	PRP$
cord-310268-8q4tk6fd	310	13	application	application	NN
cord-310268-8q4tk6fd	310	14	in	in	IN
cord-310268-8q4tk6fd	310	15	human	human	JJ
cord-310268-8q4tk6fd	310	16	disease	disease	NN
cord-310268-8q4tk6fd	310	17	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	310	18	and	and	CC
cord-310268-8q4tk6fd	310	19	therapy	therapy	NN
cord-310268-8q4tk6fd	310	20	,	,	,
cord-310268-8q4tk6fd	310	21	we	-PRON-	PRP
cord-310268-8q4tk6fd	310	22	have	have	VBP
cord-310268-8q4tk6fd	310	23	shown	show	VBN
cord-310268-8q4tk6fd	310	24	that	that	IN
cord-310268-8q4tk6fd	310	25	DNA	dna	NN
cord-310268-8q4tk6fd	310	26	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	310	27	have	have	VBP
cord-310268-8q4tk6fd	310	28	great	great	JJ
cord-310268-8q4tk6fd	310	29	potential	potential	NN
cord-310268-8q4tk6fd	310	30	to	to	TO
cord-310268-8q4tk6fd	310	31	be	be	VB
cord-310268-8q4tk6fd	310	32	used	use	VBN
cord-310268-8q4tk6fd	310	33	as	as	IN
cord-310268-8q4tk6fd	310	34	an	an	DT
cord-310268-8q4tk6fd	310	35	alternative	alternative	NN
cord-310268-8q4tk6fd	310	36	to	to	IN
cord-310268-8q4tk6fd	310	37	antibodies	antibody	NNS
cord-310268-8q4tk6fd	310	38	.	.	.
cord-310268-8q4tk6fd	311	1	Since	since	IN
cord-310268-8q4tk6fd	311	2	the	the	DT
cord-310268-8q4tk6fd	311	3	first	first	JJ
cord-310268-8q4tk6fd	311	4	monoclonal	monoclonal	JJ
cord-310268-8q4tk6fd	311	5	antibody	antibody	NN
cord-310268-8q4tk6fd	311	6	was	be	VBD
cord-310268-8q4tk6fd	311	7	produced	produce	VBN
cord-310268-8q4tk6fd	311	8	in	in	IN
cord-310268-8q4tk6fd	311	9	1970s	1970	NNS
cord-310268-8q4tk6fd	311	10	,	,	,
cord-310268-8q4tk6fd	311	11	antibodies	antibody	NNS
cord-310268-8q4tk6fd	311	12	have	have	VBP
cord-310268-8q4tk6fd	311	13	been	be	VBN
cord-310268-8q4tk6fd	311	14	successfully	successfully	RB
cord-310268-8q4tk6fd	311	15	and	and	CC
cord-310268-8q4tk6fd	311	16	extensively	extensively	RB
cord-310268-8q4tk6fd	311	17	used	use	VBN
cord-310268-8q4tk6fd	311	18	in	in	IN
cord-310268-8q4tk6fd	311	19	the	the	DT
cord-310268-8q4tk6fd	311	20	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	311	21	and	and	CC
cord-310268-8q4tk6fd	311	22	therapy	therapy	NN
cord-310268-8q4tk6fd	311	23	of	of	IN
cord-310268-8q4tk6fd	311	24	human	human	JJ
cord-310268-8q4tk6fd	311	25	diseases	disease	NNS
cord-310268-8q4tk6fd	311	26	.	.	.
cord-310268-8q4tk6fd	312	1	Aptamers	aptamer	NNS
cord-310268-8q4tk6fd	312	2	are	be	VBP
cord-310268-8q4tk6fd	312	3	expected	expect	VBN
cord-310268-8q4tk6fd	312	4	to	to	TO
cord-310268-8q4tk6fd	312	5	achieve	achieve	VB
cord-310268-8q4tk6fd	312	6	a	a	DT
cord-310268-8q4tk6fd	312	7	similar	similar	JJ
cord-310268-8q4tk6fd	312	8	success	success	NN
cord-310268-8q4tk6fd	312	9	to	to	IN
cord-310268-8q4tk6fd	312	10	antibodies	antibody	NNS
cord-310268-8q4tk6fd	312	11	.	.	.
cord-310268-8q4tk6fd	313	1	Because	because	IN
cord-310268-8q4tk6fd	313	2	of	of	IN
cord-310268-8q4tk6fd	313	3	their	-PRON-	PRP$
cord-310268-8q4tk6fd	313	4	stability	stability	NN
cord-310268-8q4tk6fd	313	5	,	,	,
cord-310268-8q4tk6fd	313	6	low	low	JJ
cord-310268-8q4tk6fd	313	7	cost	cost	NN
cord-310268-8q4tk6fd	313	8	and	and	CC
cord-310268-8q4tk6fd	313	9	facile	facile	JJ
cord-310268-8q4tk6fd	313	10	manipulation	manipulation	NN
cord-310268-8q4tk6fd	313	11	,	,	,
cord-310268-8q4tk6fd	313	12	DNA	dna	NN
cord-310268-8q4tk6fd	313	13	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	313	14	will	will	MD
cord-310268-8q4tk6fd	313	15	continue	continue	VB
cord-310268-8q4tk6fd	313	16	to	to	TO
cord-310268-8q4tk6fd	313	17	be	be	VB
cord-310268-8q4tk6fd	313	18	extensively	extensively	RB
cord-310268-8q4tk6fd	313	19	studied	study	VBN
cord-310268-8q4tk6fd	313	20	and	and	CC
cord-310268-8q4tk6fd	313	21	applied	apply	VBD
cord-310268-8q4tk6fd	313	22	.	.	.
cord-310268-8q4tk6fd	314	1	Although	although	IN
cord-310268-8q4tk6fd	314	2	modified	modify	VBN
cord-310268-8q4tk6fd	314	3	RNA	RNA	NNP
cord-310268-8q4tk6fd	314	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	314	5	have	have	VBP
cord-310268-8q4tk6fd	314	6	enhanced	enhance	VBN
cord-310268-8q4tk6fd	314	7	stability	stability	NN
cord-310268-8q4tk6fd	314	8	,	,	,
cord-310268-8q4tk6fd	314	9	the	the	DT
cord-310268-8q4tk6fd	314	10	high	high	JJ
cord-310268-8q4tk6fd	314	11	cost	cost	NN
cord-310268-8q4tk6fd	314	12	of	of	IN
cord-310268-8q4tk6fd	314	13	chemically	chemically	RB
cord-310268-8q4tk6fd	314	14	modified	modify	VBN
cord-310268-8q4tk6fd	314	15	RNA	RNA	NNP
cord-310268-8q4tk6fd	314	16	might	may	MD
cord-310268-8q4tk6fd	314	17	limit	limit	VB
cord-310268-8q4tk6fd	314	18	their	-PRON-	PRP$
cord-310268-8q4tk6fd	314	19	study	study	NN
cord-310268-8q4tk6fd	314	20	and	and	CC
cord-310268-8q4tk6fd	314	21	application	application	NN
cord-310268-8q4tk6fd	314	22	.	.	.
cord-310268-8q4tk6fd	315	1	However	however	RB
cord-310268-8q4tk6fd	315	2	,	,	,
cord-310268-8q4tk6fd	315	3	RNA	RNA	NNP
cord-310268-8q4tk6fd	315	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	315	5	hold	hold	VBP
cord-310268-8q4tk6fd	315	6	an	an	DT
cord-310268-8q4tk6fd	315	7	advantage	advantage	NN
cord-310268-8q4tk6fd	315	8	in	in	IN
cord-310268-8q4tk6fd	315	9	providing	provide	VBG
cord-310268-8q4tk6fd	315	10	more	more	RBR
cord-310268-8q4tk6fd	315	11	complex	complex	JJ
cord-310268-8q4tk6fd	315	12	and	and	CC
cord-310268-8q4tk6fd	315	13	diverse	diverse	JJ
cord-310268-8q4tk6fd	315	14	3D	3d	JJ
cord-310268-8q4tk6fd	315	15	structures	structure	NNS
cord-310268-8q4tk6fd	315	16	,	,	,
cord-310268-8q4tk6fd	315	17	which	which	WDT
cord-310268-8q4tk6fd	315	18	is	be	VBZ
cord-310268-8q4tk6fd	315	19	helpful	helpful	JJ
cord-310268-8q4tk6fd	315	20	for	for	IN
cord-310268-8q4tk6fd	315	21	selecting	select	VBG
cord-310268-8q4tk6fd	315	22	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	315	23	with	with	IN
cord-310268-8q4tk6fd	315	24	high	high	JJ
cord-310268-8q4tk6fd	315	25	affinity	affinity	NN
cord-310268-8q4tk6fd	315	26	for	for	IN
cord-310268-8q4tk6fd	315	27	complex	complex	JJ
cord-310268-8q4tk6fd	315	28	targets	target	NNS
cord-310268-8q4tk6fd	315	29	needed	need	VBN
cord-310268-8q4tk6fd	315	30	for	for	IN
cord-310268-8q4tk6fd	315	31	disease	disease	NN
cord-310268-8q4tk6fd	315	32	therapy	therapy	NN
cord-310268-8q4tk6fd	315	33	.	.	.
cord-310268-8q4tk6fd	316	1	Therefore	therefore	RB
cord-310268-8q4tk6fd	316	2	,	,	,
cord-310268-8q4tk6fd	316	3	DNA	DNA	NNP
cord-310268-8q4tk6fd	316	4	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	316	5	might	may	MD
cord-310268-8q4tk6fd	316	6	have	have	VB
cord-310268-8q4tk6fd	316	7	more	more	RBR
cord-310268-8q4tk6fd	316	8	promising	promising	JJ
cord-310268-8q4tk6fd	316	9	application	application	NN
cord-310268-8q4tk6fd	316	10	in	in	IN
cord-310268-8q4tk6fd	316	11	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	316	12	and	and	CC
cord-310268-8q4tk6fd	316	13	in	in	IN
cord-310268-8q4tk6fd	316	14	vivo	vivo	NN
cord-310268-8q4tk6fd	316	15	imaging	imaging	NN
cord-310268-8q4tk6fd	316	16	,	,	,
cord-310268-8q4tk6fd	316	17	while	while	IN
cord-310268-8q4tk6fd	316	18	modified	modify	VBN
cord-310268-8q4tk6fd	316	19	RNA	RNA	NNP
cord-310268-8q4tk6fd	316	20	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	316	21	might	may	MD
cord-310268-8q4tk6fd	316	22	have	have	VB
cord-310268-8q4tk6fd	316	23	more	more	RBR
cord-310268-8q4tk6fd	316	24	promising	promising	JJ
cord-310268-8q4tk6fd	316	25	application	application	NN
cord-310268-8q4tk6fd	316	26	in	in	IN
cord-310268-8q4tk6fd	316	27	therapy	therapy	NN
cord-310268-8q4tk6fd	316	28	.	.	.
cord-310268-8q4tk6fd	317	1	In	in	IN
cord-310268-8q4tk6fd	317	2	the	the	DT
cord-310268-8q4tk6fd	317	3	era	era	NN
cord-310268-8q4tk6fd	317	4	of	of	IN
cord-310268-8q4tk6fd	317	5	personalized	personalized	JJ
cord-310268-8q4tk6fd	317	6	medicine	medicine	NN
cord-310268-8q4tk6fd	317	7	,	,	,
cord-310268-8q4tk6fd	317	8	DNA	DNA	NNP
cord-310268-8q4tk6fd	317	9	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	317	10	-	-	HYPH
cord-310268-8q4tk6fd	317	11	based	base	VBN
cord-310268-8q4tk6fd	317	12	therapeutics	therapeutic	NNS
cord-310268-8q4tk6fd	317	13	and	and	CC
cord-310268-8q4tk6fd	317	14	diagnostics	diagnostic	NNS
cord-310268-8q4tk6fd	317	15	are	be	VBP
cord-310268-8q4tk6fd	317	16	believed	believe	VBN
cord-310268-8q4tk6fd	317	17	to	to	TO
cord-310268-8q4tk6fd	317	18	have	have	VB
cord-310268-8q4tk6fd	317	19	great	great	JJ
cord-310268-8q4tk6fd	317	20	potential	potential	NN
cord-310268-8q4tk6fd	317	21	for	for	IN
cord-310268-8q4tk6fd	317	22	extensive	extensive	JJ
cord-310268-8q4tk6fd	317	23	application	application	NN
cord-310268-8q4tk6fd	317	24	because	because	IN
cord-310268-8q4tk6fd	317	25	of	of	IN
cord-310268-8q4tk6fd	317	26	their	-PRON-	PRP$
cord-310268-8q4tk6fd	317	27	flexibility	flexibility	NN
cord-310268-8q4tk6fd	317	28	to	to	TO
cord-310268-8q4tk6fd	317	29	specifically	specifically	RB
cord-310268-8q4tk6fd	317	30	bind	bind	VB
cord-310268-8q4tk6fd	317	31	to	to	IN
cord-310268-8q4tk6fd	317	32	any	any	DT
cord-310268-8q4tk6fd	317	33	molecule	molecule	NN
cord-310268-8q4tk6fd	317	34	targets	target	NNS
cord-310268-8q4tk6fd	317	35	.	.	.
cord-310268-8q4tk6fd	318	1	Before	before	IN
cord-310268-8q4tk6fd	318	2	they	-PRON-	PRP
cord-310268-8q4tk6fd	318	3	can	can	MD
cord-310268-8q4tk6fd	318	4	be	be	VB
cord-310268-8q4tk6fd	318	5	widely	widely	RB
cord-310268-8q4tk6fd	318	6	applied	apply	VBN
cord-310268-8q4tk6fd	318	7	,	,	,
cord-310268-8q4tk6fd	318	8	there	there	EX
cord-310268-8q4tk6fd	318	9	are	be	VBP
cord-310268-8q4tk6fd	318	10	still	still	RB
cord-310268-8q4tk6fd	318	11	many	many	JJ
cord-310268-8q4tk6fd	318	12	problems	problem	NNS
cord-310268-8q4tk6fd	318	13	that	that	WDT
cord-310268-8q4tk6fd	318	14	remain	remain	VBP
cord-310268-8q4tk6fd	318	15	to	to	TO
cord-310268-8q4tk6fd	318	16	be	be	VB
cord-310268-8q4tk6fd	318	17	addressed	address	VBN
cord-310268-8q4tk6fd	318	18	.	.	.
cord-310268-8q4tk6fd	319	1	Problems	problem	NNS
cord-310268-8q4tk6fd	319	2	like	like	IN
cord-310268-8q4tk6fd	319	3	nuclease	nuclease	NNP
cord-310268-8q4tk6fd	319	4	degradation	degradation	NN
cord-310268-8q4tk6fd	319	5	,	,	,
cord-310268-8q4tk6fd	319	6	quick	quick	JJ
cord-310268-8q4tk6fd	319	7	renal	renal	JJ
cord-310268-8q4tk6fd	319	8	excretion	excretion	NN
cord-310268-8q4tk6fd	319	9	and	and	CC
cord-310268-8q4tk6fd	319	10	potential	potential	JJ
cord-310268-8q4tk6fd	319	11	cross	cross	NN
cord-310268-8q4tk6fd	319	12	-	-	NN
cord-310268-8q4tk6fd	319	13	reactivity	reactivity	NN
cord-310268-8q4tk6fd	319	14	of	of	IN
cord-310268-8q4tk6fd	319	15	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	319	16	should	should	MD
cord-310268-8q4tk6fd	319	17	be	be	VB
cord-310268-8q4tk6fd	319	18	analyzed	analyze	VBN
cord-310268-8q4tk6fd	319	19	in	in	IN
cord-310268-8q4tk6fd	319	20	future	future	JJ
cord-310268-8q4tk6fd	319	21	studies	study	NNS
cord-310268-8q4tk6fd	319	22	.	.	.
cord-310268-8q4tk6fd	320	1	Systematic	systematic	JJ
cord-310268-8q4tk6fd	320	2	evolution	evolution	NN
cord-310268-8q4tk6fd	320	3	of	of	IN
cord-310268-8q4tk6fd	320	4	ligands	ligand	NNS
cord-310268-8q4tk6fd	320	5	by	by	IN
cord-310268-8q4tk6fd	320	6	exponential	exponential	JJ
cord-310268-8q4tk6fd	320	7	enrichment	enrichment	NN
cord-310268-8q4tk6fd	320	8	:	:	:
cord-310268-8q4tk6fd	320	9	RNA	rna	NN
cord-310268-8q4tk6fd	320	10	ligands	ligand	NNS
cord-310268-8q4tk6fd	320	11	to	to	IN
cord-310268-8q4tk6fd	320	12	bacteriophage	bacteriophage	NN
cord-310268-8q4tk6fd	320	13	T4	T4	NNP
cord-310268-8q4tk6fd	320	14	DNA	DNA	NNP
cord-310268-8q4tk6fd	320	15	polymerase	polymerase	NN
cord-310268-8q4tk6fd	321	1	In	in	IN
cord-310268-8q4tk6fd	321	2	vitro	vitro	FW
cord-310268-8q4tk6fd	321	3	selection	selection	NN
cord-310268-8q4tk6fd	321	4	of	of	IN
cord-310268-8q4tk6fd	321	5	RNA	RNA	NNP
cord-310268-8q4tk6fd	321	6	molecules	molecule	NNS
cord-310268-8q4tk6fd	321	7	that	that	WDT
cord-310268-8q4tk6fd	321	8	bind	bind	VBP
cord-310268-8q4tk6fd	321	9	specific	specific	JJ
cord-310268-8q4tk6fd	321	10	ligands	ligand	NNS
cord-310268-8q4tk6fd	321	11	Selection	Selection	NNP
cord-310268-8q4tk6fd	321	12	in	in	IN
cord-310268-8q4tk6fd	321	13	vitro	vitro	FW
cord-310268-8q4tk6fd	321	14	of	of	IN
cord-310268-8q4tk6fd	321	15	single	single	RB
cord-310268-8q4tk6fd	321	16	-	-	HYPH
cord-310268-8q4tk6fd	321	17	stranded	strand	VBN
cord-310268-8q4tk6fd	321	18	DNA	dna	NN
cord-310268-8q4tk6fd	321	19	molecules	molecule	NNS
cord-310268-8q4tk6fd	321	20	that	that	WDT
cord-310268-8q4tk6fd	321	21	fold	fold	VBP
cord-310268-8q4tk6fd	321	22	into	into	IN
cord-310268-8q4tk6fd	321	23	specific	specific	JJ
cord-310268-8q4tk6fd	321	24	ligand	ligand	NN
cord-310268-8q4tk6fd	321	25	-	-	HYPH
cord-310268-8q4tk6fd	321	26	binding	bind	VBG
cord-310268-8q4tk6fd	321	27	structures	structure	NNS
cord-310268-8q4tk6fd	321	28	Selection	Selection	NNP
cord-310268-8q4tk6fd	321	29	of	of	IN
cord-310268-8q4tk6fd	321	30	single	single	RB
cord-310268-8q4tk6fd	321	31	-	-	HYPH
cord-310268-8q4tk6fd	321	32	stranded	strand	VBN
cord-310268-8q4tk6fd	321	33	DNA	dna	NN
cord-310268-8q4tk6fd	321	34	molecules	molecule	NNS
cord-310268-8q4tk6fd	321	35	that	that	WDT
cord-310268-8q4tk6fd	321	36	bind	bind	VBP
cord-310268-8q4tk6fd	321	37	and	and	CC
cord-310268-8q4tk6fd	321	38	inhibit	inhibit	VB
cord-310268-8q4tk6fd	321	39	human	human	JJ
cord-310268-8q4tk6fd	321	40	thrombin	thrombin	NN
cord-310268-8q4tk6fd	321	41	Aptamers	Aptamers	NNPS
cord-310268-8q4tk6fd	321	42	as	as	IN
cord-310268-8q4tk6fd	321	43	therapeutics	therapeutic	NNS
cord-310268-8q4tk6fd	321	44	Single	Single	NNP
cord-310268-8q4tk6fd	321	45	-	-	HYPH
cord-310268-8q4tk6fd	321	46	Stranded	Stranded	NNP
cord-310268-8q4tk6fd	321	47	DNA	DNA	NNP
cord-310268-8q4tk6fd	321	48	Aptamers	Aptamers	NNP
cord-310268-8q4tk6fd	321	49	against	against	IN
cord-310268-8q4tk6fd	321	50	Pathogens	Pathogens	NNPS
cord-310268-8q4tk6fd	321	51	and	and	CC
cord-310268-8q4tk6fd	321	52	Toxins	toxin	NNS
cord-310268-8q4tk6fd	321	53	:	:	:
cord-310268-8q4tk6fd	321	54	Identification	identification	NN
cord-310268-8q4tk6fd	321	55	and	and	CC
cord-310268-8q4tk6fd	321	56	Biosensing	Biosensing	NNP
cord-310268-8q4tk6fd	321	57	Applications	Applications	NNPS
cord-310268-8q4tk6fd	322	1	A	a	DT
cord-310268-8q4tk6fd	322	2	Highlight	Highlight	NNP
cord-310268-8q4tk6fd	322	3	of	of	IN
cord-310268-8q4tk6fd	322	4	Recent	Recent	NNP
cord-310268-8q4tk6fd	322	5	Advances	Advances	NNPS
cord-310268-8q4tk6fd	322	6	in	in	IN
cord-310268-8q4tk6fd	322	7	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	322	8	Technology	Technology	NNP
cord-310268-8q4tk6fd	322	9	and	and	CC
cord-310268-8q4tk6fd	322	10	Its	-PRON-	PRP$
cord-310268-8q4tk6fd	322	11	Application	Application	NNP
cord-310268-8q4tk6fd	322	12	Aptamers	Aptamers	NNPS
cord-310268-8q4tk6fd	322	13	and	and	CC
cord-310268-8q4tk6fd	322	14	their	-PRON-	PRP$
cord-310268-8q4tk6fd	322	15	biological	biological	JJ
cord-310268-8q4tk6fd	322	16	applications	application	NNS
cord-310268-8q4tk6fd	322	17	Applications	application	NNS
cord-310268-8q4tk6fd	322	18	of	of	IN
cord-310268-8q4tk6fd	322	19	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	322	20	for	for	IN
cord-310268-8q4tk6fd	322	21	chemistry	chemistry	NN
cord-310268-8q4tk6fd	322	22	analysis	analysis	NN
cord-310268-8q4tk6fd	322	23	,	,	,
cord-310268-8q4tk6fd	322	24	medicine	medicine	NN
cord-310268-8q4tk6fd	322	25	and	and	CC
cord-310268-8q4tk6fd	322	26	food	food	NN
cord-310268-8q4tk6fd	322	27	security	security	NN
cord-310268-8q4tk6fd	322	28	Outlook	Outlook	NNP
cord-310268-8q4tk6fd	322	29	for	for	IN
cord-310268-8q4tk6fd	322	30	Aptamers	Aptamers	NNPS
cord-310268-8q4tk6fd	322	31	after	after	IN
cord-310268-8q4tk6fd	322	32	Twenty	Twenty	NNP
cord-310268-8q4tk6fd	322	33	Five	five	CD
cord-310268-8q4tk6fd	322	34	Years	year	NNS
cord-310268-8q4tk6fd	323	1	RNA	RNA	NNP
cord-310268-8q4tk6fd	323	2	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	323	3	as	as	IN
cord-310268-8q4tk6fd	323	4	genetic	genetic	JJ
cord-310268-8q4tk6fd	323	5	control	control	NN
cord-310268-8q4tk6fd	323	6	devices	device	NNS
cord-310268-8q4tk6fd	323	7	:	:	:
cord-310268-8q4tk6fd	324	1	The	the	DT
cord-310268-8q4tk6fd	324	2	potential	potential	NN
cord-310268-8q4tk6fd	324	3	of	of	IN
cord-310268-8q4tk6fd	324	4	riboswitches	riboswitche	NNS
cord-310268-8q4tk6fd	324	5	as	as	IN
cord-310268-8q4tk6fd	324	6	synthetic	synthetic	JJ
cord-310268-8q4tk6fd	324	7	elements	element	NNS
cord-310268-8q4tk6fd	324	8	for	for	IN
cord-310268-8q4tk6fd	324	9	regulating	regulate	VBG
cord-310268-8q4tk6fd	324	10	gene	gene	NN
cord-310268-8q4tk6fd	324	11	expression	expression	NN
cord-310268-8q4tk6fd	324	12	Pegaptanib	Pegaptanib	NNP
cord-310268-8q4tk6fd	324	13	(	(	-LRB-
cord-310268-8q4tk6fd	324	14	Macugen	Macugen	NNP
cord-310268-8q4tk6fd	324	15	)	)	-RRB-
cord-310268-8q4tk6fd	324	16	:	:	:
cord-310268-8q4tk6fd	325	1	Treating	treat	VBG
cord-310268-8q4tk6fd	325	2	neovascular	neovascular	JJ
cord-310268-8q4tk6fd	325	3	age	age	NN
cord-310268-8q4tk6fd	325	4	-	-	HYPH
cord-310268-8q4tk6fd	325	5	related	relate	VBN
cord-310268-8q4tk6fd	325	6	macular	macular	JJ
cord-310268-8q4tk6fd	325	7	degeneration	degeneration	NN
cord-310268-8q4tk6fd	325	8	and	and	CC
cord-310268-8q4tk6fd	325	9	current	current	JJ
cord-310268-8q4tk6fd	325	10	role	role	NN
cord-310268-8q4tk6fd	325	11	in	in	IN
cord-310268-8q4tk6fd	325	12	clinical	clinical	JJ
cord-310268-8q4tk6fd	325	13	practice	practice	NN
cord-310268-8q4tk6fd	326	1	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	326	2	nanomedicine	nanomedicine	NN
cord-310268-8q4tk6fd	326	3	for	for	IN
cord-310268-8q4tk6fd	326	4	cancer	cancer	NN
cord-310268-8q4tk6fd	326	5	therapeutics	therapeutic	NNS
cord-310268-8q4tk6fd	326	6	:	:	:
cord-310268-8q4tk6fd	326	7	Barriers	barrier	NNS
cord-310268-8q4tk6fd	326	8	and	and	CC
cord-310268-8q4tk6fd	326	9	potential	potential	NN
cord-310268-8q4tk6fd	326	10	for	for	IN
cord-310268-8q4tk6fd	326	11	translation	translation	NN
cord-310268-8q4tk6fd	326	12	Aptamers	Aptamers	NNP
cord-310268-8q4tk6fd	326	13	Market	Market	NNP
cord-310268-8q4tk6fd	326	14	-	-	HYPH
cord-310268-8q4tk6fd	326	15	Global	Global	NNP
cord-310268-8q4tk6fd	326	16	Forecast	Forecast	NNP
cord-310268-8q4tk6fd	326	17	to	to	IN
cord-310268-8q4tk6fd	326	18	2020	2020	CD
cord-310268-8q4tk6fd	326	19	Post	Post	NNP
cord-310268-8q4tk6fd	326	20	-	-	JJ
cord-310268-8q4tk6fd	326	21	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	326	22	chemical	chemical	NN
cord-310268-8q4tk6fd	326	23	optimization	optimization	NN
cord-310268-8q4tk6fd	326	24	of	of	IN
cord-310268-8q4tk6fd	326	25	a	a	DT
cord-310268-8q4tk6fd	326	26	trypanosome	trypanosome	NN
cord-310268-8q4tk6fd	326	27	-	-	HYPH
cord-310268-8q4tk6fd	326	28	specific	specific	JJ
cord-310268-8q4tk6fd	326	29	RNA	RNA	NNP
cord-310268-8q4tk6fd	326	30	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	326	31	Building	building	NN
cord-310268-8q4tk6fd	326	32	oligonucleotide	oligonucleotide	JJ
cord-310268-8q4tk6fd	326	33	therapeutics	therapeutic	NNS
cord-310268-8q4tk6fd	326	34	using	use	VBG
cord-310268-8q4tk6fd	326	35	non	non	JJ
cord-310268-8q4tk6fd	326	36	-	-	JJ
cord-310268-8q4tk6fd	326	37	natural	natural	JJ
cord-310268-8q4tk6fd	326	38	chemistries	chemistry	NNS
cord-310268-8q4tk6fd	326	39	Inhibition	inhibition	NN
cord-310268-8q4tk6fd	326	40	of	of	IN
cord-310268-8q4tk6fd	326	41	HIV-1	HIV-1	NNP
cord-310268-8q4tk6fd	326	42	protease	protease	NN
cord-310268-8q4tk6fd	326	43	expression	expression	NN
cord-310268-8q4tk6fd	326	44	in	in	IN
cord-310268-8q4tk6fd	326	45	T	t	NN
cord-310268-8q4tk6fd	326	46	cells	cell	NNS
cord-310268-8q4tk6fd	326	47	owing	owe	VBG
cord-310268-8q4tk6fd	326	48	to	to	IN
cord-310268-8q4tk6fd	326	49	DNA	DNA	NNP
cord-310268-8q4tk6fd	326	50	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	326	51	-	-	HYPH
cord-310268-8q4tk6fd	326	52	mediated	mediate	VBN
cord-310268-8q4tk6fd	326	53	specific	specific	JJ
cord-310268-8q4tk6fd	326	54	delivery	delivery	NN
cord-310268-8q4tk6fd	326	55	of	of	IN
cord-310268-8q4tk6fd	326	56	siRNA	siRNA	NNP
cord-310268-8q4tk6fd	326	57	Improving	improve	VBG
cord-310268-8q4tk6fd	326	58	the	the	DT
cord-310268-8q4tk6fd	326	59	Stability	Stability	NNP
cord-310268-8q4tk6fd	326	60	of	of	IN
cord-310268-8q4tk6fd	326	61	Aptamers	Aptamers	NNPS
cord-310268-8q4tk6fd	326	62	by	by	IN
cord-310268-8q4tk6fd	326	63	Chemical	Chemical	NNP
cord-310268-8q4tk6fd	326	64	Modification	Modification	NNP
cord-310268-8q4tk6fd	326	65	Influence	influence	NN
cord-310268-8q4tk6fd	326	66	of	of	IN
cord-310268-8q4tk6fd	326	67	the	the	DT
cord-310268-8q4tk6fd	326	68	2	2	CD
cord-310268-8q4tk6fd	326	69	1	1	CD
cord-310268-8q4tk6fd	326	70	-hydroxyl	-hydroxyl	CD
cord-310268-8q4tk6fd	326	71	group	group	NN
cord-310268-8q4tk6fd	326	72	conformation	conformation	NN
cord-310268-8q4tk6fd	326	73	on	on	IN
cord-310268-8q4tk6fd	326	74	the	the	DT
cord-310268-8q4tk6fd	326	75	stability	stability	NN
cord-310268-8q4tk6fd	326	76	of	of	IN
cord-310268-8q4tk6fd	326	77	A	a	DT
cord-310268-8q4tk6fd	326	78	-	-	HYPH
cord-310268-8q4tk6fd	326	79	form	form	NN
cord-310268-8q4tk6fd	326	80	helices	helix	NNS
cord-310268-8q4tk6fd	326	81	in	in	IN
cord-310268-8q4tk6fd	326	82	RNA	RNA	NNP
cord-310268-8q4tk6fd	326	83	Oligonucleotide	Oligonucleotide	NNP
cord-310268-8q4tk6fd	326	84	Aptamers	Aptamers	NNPS
cord-310268-8q4tk6fd	326	85	:	:	:
cord-310268-8q4tk6fd	326	86	New	New	NNP
cord-310268-8q4tk6fd	326	87	Tools	Tools	NNPS
cord-310268-8q4tk6fd	326	88	for	for	IN
cord-310268-8q4tk6fd	326	89	Targeted	Targeted	NNP
cord-310268-8q4tk6fd	326	90	Cancer	Cancer	NNP
cord-310268-8q4tk6fd	326	91	Therapy	Therapy	NNP
cord-310268-8q4tk6fd	327	1	In	in	IN
cord-310268-8q4tk6fd	327	2	vitro	vitro	FW
cord-310268-8q4tk6fd	327	3	selection	selection	NN
cord-310268-8q4tk6fd	327	4	of	of	IN
cord-310268-8q4tk6fd	327	5	functional	functional	JJ
cord-310268-8q4tk6fd	327	6	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	327	7	acids	acid	NNS
cord-310268-8q4tk6fd	327	8	Aptamers	Aptamers	NNP
cord-310268-8q4tk6fd	327	9	Overview	Overview	NNP
cord-310268-8q4tk6fd	327	10	:	:	:
cord-310268-8q4tk6fd	328	1	Selection	selection	NN
cord-310268-8q4tk6fd	328	2	,	,	,
cord-310268-8q4tk6fd	328	3	Features	Features	NNPS
cord-310268-8q4tk6fd	328	4	and	and	CC
cord-310268-8q4tk6fd	328	5	Applications	Applications	NNPS
cord-310268-8q4tk6fd	328	6	Single	Single	NNP
cord-310268-8q4tk6fd	328	7	-	-	HYPH
cord-310268-8q4tk6fd	328	8	stranded	strand	VBN
cord-310268-8q4tk6fd	328	9	DNA	dna	NN
cord-310268-8q4tk6fd	328	10	(	(	-LRB-
cord-310268-8q4tk6fd	328	11	ssDNA	ssdna	NN
cord-310268-8q4tk6fd	328	12	)	)	-RRB-
cord-310268-8q4tk6fd	328	13	production	production	NN
cord-310268-8q4tk6fd	328	14	in	in	IN
cord-310268-8q4tk6fd	328	15	DNA	DNA	NNP
cord-310268-8q4tk6fd	328	16	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	328	17	generation	generation	NN
cord-310268-8q4tk6fd	328	18	Development	Development	NNP
cord-310268-8q4tk6fd	328	19	of	of	IN
cord-310268-8q4tk6fd	328	20	a	a	DT
cord-310268-8q4tk6fd	328	21	novel	novel	JJ
cord-310268-8q4tk6fd	328	22	DNA	dna	NN
cord-310268-8q4tk6fd	328	23	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	328	24	ligand	ligand	NN
cord-310268-8q4tk6fd	328	25	targeting	target	VBG
cord-310268-8q4tk6fd	328	26	to	to	IN
cord-310268-8q4tk6fd	328	27	primary	primary	JJ
cord-310268-8q4tk6fd	328	28	cultured	cultured	JJ
cord-310268-8q4tk6fd	328	29	tumor	tumor	NN
cord-310268-8q4tk6fd	328	30	endothelial	endothelial	JJ
cord-310268-8q4tk6fd	328	31	cells	cell	NNS
cord-310268-8q4tk6fd	328	32	by	by	IN
cord-310268-8q4tk6fd	328	33	a	a	DT
cord-310268-8q4tk6fd	328	34	cell	cell	NN
cord-310268-8q4tk6fd	328	35	-	-	HYPH
cord-310268-8q4tk6fd	328	36	based	base	VBN
cord-310268-8q4tk6fd	328	37	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	328	38	method	method	NN
cord-310268-8q4tk6fd	328	39	DNA	dna	NN
cord-310268-8q4tk6fd	328	40	aptamer	aptamer	NN
cord-310268-8q4tk6fd	328	41	evolved	evolve	VBN
cord-310268-8q4tk6fd	328	42	by	by	IN
cord-310268-8q4tk6fd	328	43	cell	cell	NN
cord-310268-8q4tk6fd	328	44	-	-	HYPH
cord-310268-8q4tk6fd	328	45	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	328	46	for	for	IN
cord-310268-8q4tk6fd	328	47	recognition	recognition	NN
cord-310268-8q4tk6fd	328	48	of	of	IN
cord-310268-8q4tk6fd	328	49	prostate	prostate	NN
cord-310268-8q4tk6fd	328	50	cancer	cancer	NN
cord-310268-8q4tk6fd	328	51	Development	Development	NNP
cord-310268-8q4tk6fd	328	52	of	of	IN
cord-310268-8q4tk6fd	328	53	an	an	DT
cord-310268-8q4tk6fd	328	54	efficient	efficient	JJ
cord-310268-8q4tk6fd	328	55	targeted	target	VBN
cord-310268-8q4tk6fd	328	56	cell	cell	NN
cord-310268-8q4tk6fd	328	57	-	-	HYPH
cord-310268-8q4tk6fd	328	58	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	328	59	procedure	procedure	NN
cord-310268-8q4tk6fd	328	60	for	for	IN
cord-310268-8q4tk6fd	328	61	DNA	DNA	NNP
cord-310268-8q4tk6fd	328	62	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	328	63	reagents	reagent	NNS
cord-310268-8q4tk6fd	328	64	A	a	DT
cord-310268-8q4tk6fd	328	65	two	two	CD
cord-310268-8q4tk6fd	328	66	-	-	HYPH
cord-310268-8q4tk6fd	328	67	step	step	NN
cord-310268-8q4tk6fd	328	68	stimulus	stimulus	NN
cord-310268-8q4tk6fd	328	69	-	-	HYPH
cord-310268-8q4tk6fd	328	70	response	response	NN
cord-310268-8q4tk6fd	328	71	cell	cell	NN
cord-310268-8q4tk6fd	328	72	-	-	HYPH
cord-310268-8q4tk6fd	328	73	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	328	74	method	method	NN
cord-310268-8q4tk6fd	328	75	to	to	TO
cord-310268-8q4tk6fd	328	76	generate	generate	VB
cord-310268-8q4tk6fd	328	77	a	a	DT
cord-310268-8q4tk6fd	328	78	DNA	dna	NN
cord-310268-8q4tk6fd	328	79	aptamer	aptamer	NN
cord-310268-8q4tk6fd	328	80	to	to	TO
cord-310268-8q4tk6fd	328	81	recognize	recognize	VB
cord-310268-8q4tk6fd	328	82	inflamed	inflamed	JJ
cord-310268-8q4tk6fd	328	83	human	human	JJ
cord-310268-8q4tk6fd	328	84	aortic	aortic	JJ
cord-310268-8q4tk6fd	328	85	endothelial	endothelial	JJ
cord-310268-8q4tk6fd	328	86	cells	cell	NNS
cord-310268-8q4tk6fd	328	87	as	as	IN
cord-310268-8q4tk6fd	328	88	a	a	DT
cord-310268-8q4tk6fd	328	89	potential	potential	NN
cord-310268-8q4tk6fd	328	90	in	in	IN
cord-310268-8q4tk6fd	328	91	vivo	vivo	NN
cord-310268-8q4tk6fd	328	92	molecular	molecular	JJ
cord-310268-8q4tk6fd	328	93	probe	probe	NN
cord-310268-8q4tk6fd	328	94	for	for	IN
cord-310268-8q4tk6fd	328	95	atherosclerosis	atherosclerosis	NN
cord-310268-8q4tk6fd	328	96	plaque	plaque	NN
cord-310268-8q4tk6fd	328	97	detection	detection	NN
cord-310268-8q4tk6fd	328	98	Evolution	evolution	NN
cord-310268-8q4tk6fd	328	99	of	of	IN
cord-310268-8q4tk6fd	328	100	DNA	dna	NN
cord-310268-8q4tk6fd	328	101	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	328	102	through	through	IN
cord-310268-8q4tk6fd	328	103	in	in	FW
cord-310268-8q4tk6fd	328	104	vitro	vitro	FW
cord-310268-8q4tk6fd	328	105	metastatic	metastatic	JJ
cord-310268-8q4tk6fd	328	106	-	-	HYPH
cord-310268-8q4tk6fd	328	107	cell	cell	NN
cord-310268-8q4tk6fd	328	108	-	-	HYPH
cord-310268-8q4tk6fd	328	109	based	base	VBN
cord-310268-8q4tk6fd	328	110	systematic	systematic	JJ
cord-310268-8q4tk6fd	328	111	evolution	evolution	NN
cord-310268-8q4tk6fd	328	112	of	of	IN
cord-310268-8q4tk6fd	328	113	ligands	ligand	NNS
cord-310268-8q4tk6fd	328	114	by	by	IN
cord-310268-8q4tk6fd	328	115	exponential	exponential	JJ
cord-310268-8q4tk6fd	328	116	enrichment	enrichment	NN
cord-310268-8q4tk6fd	328	117	for	for	IN
cord-310268-8q4tk6fd	328	118	metastatic	metastatic	JJ
cord-310268-8q4tk6fd	328	119	cancer	cancer	NN
cord-310268-8q4tk6fd	328	120	recognition	recognition	NN
cord-310268-8q4tk6fd	328	121	and	and	CC
cord-310268-8q4tk6fd	328	122	imaging	image	VBG
cord-310268-8q4tk6fd	328	123	In	in	IN
cord-310268-8q4tk6fd	328	124	silico	silico	NN
cord-310268-8q4tk6fd	328	125	maturation	maturation	NN
cord-310268-8q4tk6fd	328	126	of	of	IN
cord-310268-8q4tk6fd	328	127	binding	binding	NN
cord-310268-8q4tk6fd	328	128	-	-	HYPH
cord-310268-8q4tk6fd	328	129	specificity	specificity	NN
cord-310268-8q4tk6fd	328	130	of	of	IN
cord-310268-8q4tk6fd	328	131	DNA	dna	NN
cord-310268-8q4tk6fd	328	132	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	328	133	against	against	IN
cord-310268-8q4tk6fd	328	134	Proteus	Proteus	NNP
cord-310268-8q4tk6fd	328	135	mirabilis	mirabilis	NNP
cord-310268-8q4tk6fd	328	136	A	a	DT
cord-310268-8q4tk6fd	328	137	novel	novel	NN
cord-310268-8q4tk6fd	328	138	protocol	protocol	NN
cord-310268-8q4tk6fd	328	139	for	for	IN
cord-310268-8q4tk6fd	328	140	generating	generate	VBG
cord-310268-8q4tk6fd	328	141	high	high	JJ
cord-310268-8q4tk6fd	328	142	-	-	HYPH
cord-310268-8q4tk6fd	328	143	affinity	affinity	NN
cord-310268-8q4tk6fd	328	144	ssDNA	ssdna	NN
cord-310268-8q4tk6fd	328	145	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	328	146	by	by	IN
cord-310268-8q4tk6fd	328	147	using	use	VBG
cord-310268-8q4tk6fd	328	148	alternating	alternate	VBG
cord-310268-8q4tk6fd	328	149	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	328	150	fields	field	NNS
cord-310268-8q4tk6fd	328	151	Magnetic	Magnetic	NNP
cord-310268-8q4tk6fd	328	152	-	-	HYPH
cord-310268-8q4tk6fd	328	153	assisted	assist	VBN
cord-310268-8q4tk6fd	328	154	rapid	rapid	JJ
cord-310268-8q4tk6fd	328	155	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	328	156	selection	selection	NN
cord-310268-8q4tk6fd	328	157	(	(	-LRB-
cord-310268-8q4tk6fd	328	158	MARAS	MARAS	NNP
cord-310268-8q4tk6fd	328	159	)	)	-RRB-
cord-310268-8q4tk6fd	328	160	for	for	IN
cord-310268-8q4tk6fd	328	161	generating	generate	VBG
cord-310268-8q4tk6fd	328	162	high	high	JJ
cord-310268-8q4tk6fd	328	163	-	-	HYPH
cord-310268-8q4tk6fd	328	164	affinity	affinity	NN
cord-310268-8q4tk6fd	328	165	DNA	dna	NN
cord-310268-8q4tk6fd	328	166	aptamer	aptamer	NN
cord-310268-8q4tk6fd	328	167	using	use	VBG
cord-310268-8q4tk6fd	328	168	rotating	rotate	VBG
cord-310268-8q4tk6fd	328	169	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	328	170	fields	field	NNS
cord-310268-8q4tk6fd	328	171	Rapid	Rapid	NNP
cord-310268-8q4tk6fd	328	172	one	one	CD
cord-310268-8q4tk6fd	328	173	-	-	HYPH
cord-310268-8q4tk6fd	328	174	step	step	NN
cord-310268-8q4tk6fd	328	175	selection	selection	NN
cord-310268-8q4tk6fd	328	176	method	method	NN
cord-310268-8q4tk6fd	328	177	for	for	IN
cord-310268-8q4tk6fd	328	178	generating	generate	VBG
cord-310268-8q4tk6fd	328	179	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	328	180	acid	acid	NN
cord-310268-8q4tk6fd	328	181	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	328	182	:	:	:
cord-310268-8q4tk6fd	329	1	Development	development	NN
cord-310268-8q4tk6fd	329	2	of	of	IN
cord-310268-8q4tk6fd	329	3	a	a	DT
cord-310268-8q4tk6fd	329	4	DNA	dna	NN
cord-310268-8q4tk6fd	329	5	aptamer	aptamer	NN
cord-310268-8q4tk6fd	329	6	against	against	IN
cord-310268-8q4tk6fd	329	7	alpha	alpha	NN
cord-310268-8q4tk6fd	329	8	-	-	HYPH
cord-310268-8q4tk6fd	329	9	bungarotoxin	bungarotoxin	NN
cord-310268-8q4tk6fd	329	10	Array	array	NN
cord-310268-8q4tk6fd	329	11	-	-	HYPH
cord-310268-8q4tk6fd	329	12	based	base	VBN
cord-310268-8q4tk6fd	329	13	evolution	evolution	NN
cord-310268-8q4tk6fd	329	14	of	of	IN
cord-310268-8q4tk6fd	329	15	DNA	dna	NN
cord-310268-8q4tk6fd	329	16	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	329	17	allows	allow	VBZ
cord-310268-8q4tk6fd	329	18	modelling	modelling	NN
cord-310268-8q4tk6fd	329	19	of	of	IN
cord-310268-8q4tk6fd	329	20	an	an	DT
cord-310268-8q4tk6fd	329	21	explicit	explicit	JJ
cord-310268-8q4tk6fd	329	22	sequence	sequence	NN
cord-310268-8q4tk6fd	329	23	-	-	HYPH
cord-310268-8q4tk6fd	329	24	fitness	fitness	NN
cord-310268-8q4tk6fd	329	25	landscape	landscape	NN
cord-310268-8q4tk6fd	329	26	Single	Single	NNP
cord-310268-8q4tk6fd	329	27	-	-	HYPH
cord-310268-8q4tk6fd	329	28	Round	Round	NNP
cord-310268-8q4tk6fd	329	29	Patterned	Patterned	NNP
cord-310268-8q4tk6fd	329	30	DNA	DNA	NNP
cord-310268-8q4tk6fd	329	31	Library	Library	NNP
cord-310268-8q4tk6fd	329	32	Microarray	Microarray	NNP
cord-310268-8q4tk6fd	329	33	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	329	34	Lead	Lead	NNP
cord-310268-8q4tk6fd	329	35	Identification	Identification	NNP
cord-310268-8q4tk6fd	330	1	The	the	DT
cord-310268-8q4tk6fd	330	2	application	application	NN
cord-310268-8q4tk6fd	330	3	of	of	IN
cord-310268-8q4tk6fd	330	4	a	a	DT
cord-310268-8q4tk6fd	330	5	modified	modify	VBN
cord-310268-8q4tk6fd	330	6	nucleotide	nucleotide	NN
cord-310268-8q4tk6fd	330	7	in	in	IN
cord-310268-8q4tk6fd	330	8	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	330	9	selection	selection	NN
cord-310268-8q4tk6fd	330	10	:	:	:
cord-310268-8q4tk6fd	331	1	Novel	novel	JJ
cord-310268-8q4tk6fd	331	2	thrombin	thrombin	NN
cord-310268-8q4tk6fd	331	3	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	331	4	containing	contain	VBG
cord-310268-8q4tk6fd	331	5	5-(1-pentynyl)-2	5-(1-pentynyl)-2	CD
cord-310268-8q4tk6fd	331	6	1	1	CD
cord-310268-8q4tk6fd	332	1	-deoxyuridine	-deoxyuridine	:
cord-310268-8q4tk6fd	332	2	Molecular	molecular	JJ
cord-310268-8q4tk6fd	332	3	evolution	evolution	NN
cord-310268-8q4tk6fd	332	4	of	of	IN
cord-310268-8q4tk6fd	332	5	functional	functional	JJ
cord-310268-8q4tk6fd	332	6	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	332	7	acids	acid	NNS
cord-310268-8q4tk6fd	332	8	with	with	IN
cord-310268-8q4tk6fd	332	9	chemical	chemical	JJ
cord-310268-8q4tk6fd	332	10	modifications	modification	NNS
cord-310268-8q4tk6fd	333	1	Novel	novel	JJ
cord-310268-8q4tk6fd	333	2	combinatorial	combinatorial	JJ
cord-310268-8q4tk6fd	333	3	selection	selection	NN
cord-310268-8q4tk6fd	333	4	of	of	IN
cord-310268-8q4tk6fd	333	5	phosphorothioate	phosphorothioate	NN
cord-310268-8q4tk6fd	333	6	oligonucleotide	oligonucleotide	JJ
cord-310268-8q4tk6fd	333	7	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	333	8	Chemically	chemically	RB
cord-310268-8q4tk6fd	333	9	modified	modify	VBN
cord-310268-8q4tk6fd	333	10	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	333	11	acid	acid	NN
cord-310268-8q4tk6fd	333	12	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	333	13	for	for	IN
cord-310268-8q4tk6fd	333	14	in	in	FW
cord-310268-8q4tk6fd	333	15	vitro	vitro	FW
cord-310268-8q4tk6fd	333	16	selections	selection	NNS
cord-310268-8q4tk6fd	333	17	:	:	:
cord-310268-8q4tk6fd	334	1	Evolving	evolve	VBG
cord-310268-8q4tk6fd	334	2	evolution	evolution	NN
cord-310268-8q4tk6fd	334	3	Effect	effect	NN
cord-310268-8q4tk6fd	334	4	of	of	IN
cord-310268-8q4tk6fd	334	5	3	3	CD
cord-310268-8q4tk6fd	334	6	1	1	CD
cord-310268-8q4tk6fd	335	1	-end	-end	:
cord-310268-8q4tk6fd	335	2	capping	cap	VBG
cord-310268-8q4tk6fd	335	3	of	of	IN
cord-310268-8q4tk6fd	335	4	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	335	5	with	with	IN
cord-310268-8q4tk6fd	335	6	various	various	JJ
cord-310268-8q4tk6fd	335	7	2	2	CD
cord-310268-8q4tk6fd	335	8	1	1	CD
cord-310268-8q4tk6fd	335	9	,	,	,
cord-310268-8q4tk6fd	335	10	4	4	CD
cord-310268-8q4tk6fd	335	11	1	1	CD
cord-310268-8q4tk6fd	335	12	-bridged	-bridge	VBN
cord-310268-8q4tk6fd	335	13	nucleotides	nucleotide	NNS
cord-310268-8q4tk6fd	335	14	:	:	:
cord-310268-8q4tk6fd	336	1	Enzymatic	enzymatic	JJ
cord-310268-8q4tk6fd	336	2	post	post	NN
cord-310268-8q4tk6fd	336	3	-	-	NN
cord-310268-8q4tk6fd	336	4	modification	modification	NN
cord-310268-8q4tk6fd	336	5	toward	toward	IN
cord-310268-8q4tk6fd	336	6	a	a	DT
cord-310268-8q4tk6fd	336	7	practical	practical	JJ
cord-310268-8q4tk6fd	336	8	use	use	NN
cord-310268-8q4tk6fd	336	9	of	of	IN
cord-310268-8q4tk6fd	336	10	polyclonal	polyclonal	JJ
cord-310268-8q4tk6fd	336	11	aptamers	aptamers	NNP
cord-310268-8q4tk6fd	336	12	Application	Application	NNP
cord-310268-8q4tk6fd	336	13	of	of	IN
cord-310268-8q4tk6fd	336	14	locked	locked	JJ
cord-310268-8q4tk6fd	336	15	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	336	16	acids	acid	NNS
cord-310268-8q4tk6fd	336	17	to	to	TO
cord-310268-8q4tk6fd	336	18	improve	improve	VB
cord-310268-8q4tk6fd	336	19	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	336	20	in	in	IN
cord-310268-8q4tk6fd	336	21	vivo	vivo	NN
cord-310268-8q4tk6fd	336	22	stability	stability	NN
cord-310268-8q4tk6fd	336	23	and	and	CC
cord-310268-8q4tk6fd	336	24	targeting	targeting	NN
cord-310268-8q4tk6fd	336	25	function	function	NN
cord-310268-8q4tk6fd	336	26	Locked	lock	VBN
cord-310268-8q4tk6fd	336	27	nucleic	nucleic	JJ
cord-310268-8q4tk6fd	336	28	acids	acid	NNS
cord-310268-8q4tk6fd	336	29	:	:	:
cord-310268-8q4tk6fd	337	1	A	a	DT
cord-310268-8q4tk6fd	337	2	promising	promising	JJ
cord-310268-8q4tk6fd	337	3	molecular	molecular	JJ
cord-310268-8q4tk6fd	337	4	family	family	NN
cord-310268-8q4tk6fd	337	5	for	for	IN
cord-310268-8q4tk6fd	337	6	gene	gene	NN
cord-310268-8q4tk6fd	337	7	-	-	HYPH
cord-310268-8q4tk6fd	337	8	function	function	NN
cord-310268-8q4tk6fd	337	9	analysis	analysis	NN
cord-310268-8q4tk6fd	337	10	and	and	CC
cord-310268-8q4tk6fd	337	11	antisense	antisense	NNP
cord-310268-8q4tk6fd	337	12	drug	drug	NN
cord-310268-8q4tk6fd	337	13	development	development	NN
cord-310268-8q4tk6fd	337	14	Selection	Selection	NNP
cord-310268-8q4tk6fd	337	15	of	of	IN
cord-310268-8q4tk6fd	337	16	LNA	LNA	NNP
cord-310268-8q4tk6fd	337	17	-	-	HYPH
cord-310268-8q4tk6fd	337	18	containing	contain	VBG
cord-310268-8q4tk6fd	337	19	DNA	DNA	NNP
cord-310268-8q4tk6fd	337	20	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	337	21	against	against	IN
cord-310268-8q4tk6fd	337	22	recombinant	recombinant	JJ
cord-310268-8q4tk6fd	337	23	human	human	NN
cord-310268-8q4tk6fd	337	24	CD73	CD73	NNP
cord-310268-8q4tk6fd	337	25	Synthesis	Synthesis	NNP
cord-310268-8q4tk6fd	337	26	and	and	CC
cord-310268-8q4tk6fd	337	27	properties	property	NNS
cord-310268-8q4tk6fd	337	28	of	of	IN
cord-310268-8q4tk6fd	337	29	mirror	mirror	NN
cord-310268-8q4tk6fd	337	30	-	-	HYPH
cord-310268-8q4tk6fd	337	31	image	image	NN
cord-310268-8q4tk6fd	337	32	DNA	dna	NN
cord-310268-8q4tk6fd	337	33	Simple	simple	JJ
cord-310268-8q4tk6fd	337	34	PEG	peg	NN
cord-310268-8q4tk6fd	337	35	Modification	modification	NN
cord-310268-8q4tk6fd	337	36	of	of	IN
cord-310268-8q4tk6fd	337	37	DNA	DNA	NNP
cord-310268-8q4tk6fd	337	38	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	338	1	Based	base	VBN
cord-310268-8q4tk6fd	338	2	on	on	IN
cord-310268-8q4tk6fd	338	3	Copper	Copper	NNP
cord-310268-8q4tk6fd	338	4	Ion	Ion	NNP
cord-310268-8q4tk6fd	338	5	Coordination	Coordination	NNP
cord-310268-8q4tk6fd	338	6	for	for	IN
cord-310268-8q4tk6fd	338	7	Tumor	tumor	NN
cord-310268-8q4tk6fd	339	1	Targeting	target	VBG
cord-310268-8q4tk6fd	339	2	A	a	DT
cord-310268-8q4tk6fd	339	3	multivalent	multivalent	JJ
cord-310268-8q4tk6fd	339	4	DNA	dna	NN
cord-310268-8q4tk6fd	339	5	aptamer	aptamer	NN
cord-310268-8q4tk6fd	339	6	specific	specific	JJ
cord-310268-8q4tk6fd	339	7	for	for	IN
cord-310268-8q4tk6fd	339	8	the	the	DT
cord-310268-8q4tk6fd	339	9	B	b	NN
cord-310268-8q4tk6fd	339	10	-	-	HYPH
cord-310268-8q4tk6fd	339	11	cell	cell	NN
cord-310268-8q4tk6fd	339	12	receptor	receptor	NN
cord-310268-8q4tk6fd	339	13	on	on	IN
cord-310268-8q4tk6fd	339	14	human	human	JJ
cord-310268-8q4tk6fd	339	15	lymphoma	lymphoma	NN
cord-310268-8q4tk6fd	339	16	and	and	CC
cord-310268-8q4tk6fd	339	17	leukemia	leukemia	NN
cord-310268-8q4tk6fd	339	18	Affinity	Affinity	NNP
cord-310268-8q4tk6fd	339	19	analysis	analysis	NN
cord-310268-8q4tk6fd	339	20	of	of	IN
cord-310268-8q4tk6fd	339	21	DNA	DNA	NNP
cord-310268-8q4tk6fd	339	22	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	339	23	-	-	HYPH
cord-310268-8q4tk6fd	339	24	peptide	peptide	NN
cord-310268-8q4tk6fd	339	25	interactions	interaction	NNS
cord-310268-8q4tk6fd	339	26	using	use	VBG
cord-310268-8q4tk6fd	339	27	gold	gold	NN
cord-310268-8q4tk6fd	339	28	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	339	29	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	339	30	-	-	HYPH
cord-310268-8q4tk6fd	339	31	functionalized	functionalize	VBN
cord-310268-8q4tk6fd	339	32	PEG	PEG	NNP
cord-310268-8q4tk6fd	339	33	-	-	HYPH
cord-310268-8q4tk6fd	339	34	PLGA	PLGA	NNP
cord-310268-8q4tk6fd	339	35	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	339	36	for	for	IN
cord-310268-8q4tk6fd	339	37	enhanced	enhanced	JJ
cord-310268-8q4tk6fd	339	38	anti	anti	JJ
cord-310268-8q4tk6fd	339	39	-	-	JJ
cord-310268-8q4tk6fd	339	40	glioma	glioma	JJ
cord-310268-8q4tk6fd	339	41	drug	drug	NN
cord-310268-8q4tk6fd	339	42	delivery	delivery	NN
cord-310268-8q4tk6fd	339	43	Selective	Selective	NNP
cord-310268-8q4tk6fd	339	44	Delivery	Delivery	NNP
cord-310268-8q4tk6fd	339	45	of	of	IN
cord-310268-8q4tk6fd	339	46	an	an	DT
cord-310268-8q4tk6fd	339	47	Anticancer	Anticancer	NNP
cord-310268-8q4tk6fd	339	48	Drug	Drug	NNP
cord-310268-8q4tk6fd	339	49	with	with	IN
cord-310268-8q4tk6fd	339	50	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	339	51	-	-	HYPH
cord-310268-8q4tk6fd	339	52	Functionalized	Functionalized	NNP
cord-310268-8q4tk6fd	339	53	Liposomes	Liposomes	NNPS
cord-310268-8q4tk6fd	339	54	to	to	IN
cord-310268-8q4tk6fd	339	55	Breast	breast	NN
cord-310268-8q4tk6fd	339	56	Cancer	Cancer	NNP
cord-310268-8q4tk6fd	339	57	Cells	cell	NNS
cord-310268-8q4tk6fd	339	58	in	in	IN
cord-310268-8q4tk6fd	339	59	vitro	vitro	FW
cord-310268-8q4tk6fd	339	60	and	and	CC
cord-310268-8q4tk6fd	339	61	in	in	IN
cord-310268-8q4tk6fd	339	62	vivo	vivo	NNP
cord-310268-8q4tk6fd	339	63	DNA	DNA	NNP
cord-310268-8q4tk6fd	339	64	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	339	65	-	-	HYPH
cord-310268-8q4tk6fd	339	66	micelle	micelle	NNP
cord-310268-8q4tk6fd	339	67	as	as	IN
cord-310268-8q4tk6fd	339	68	an	an	DT
cord-310268-8q4tk6fd	339	69	efficient	efficient	JJ
cord-310268-8q4tk6fd	339	70	detection	detection	NN
cord-310268-8q4tk6fd	339	71	/	/	SYM
cord-310268-8q4tk6fd	339	72	delivery	delivery	NN
cord-310268-8q4tk6fd	339	73	vehicle	vehicle	NN
cord-310268-8q4tk6fd	339	74	toward	toward	IN
cord-310268-8q4tk6fd	339	75	cancer	cancer	NN
cord-310268-8q4tk6fd	339	76	cells	cell	NNS
cord-310268-8q4tk6fd	339	77	Applications	application	NNS
cord-310268-8q4tk6fd	339	78	of	of	IN
cord-310268-8q4tk6fd	339	79	Aptasensors	Aptasensors	NNPS
cord-310268-8q4tk6fd	339	80	in	in	IN
cord-310268-8q4tk6fd	339	81	Clinical	Clinical	NNP
cord-310268-8q4tk6fd	339	82	Diagnostics	Diagnostics	NNPS
cord-310268-8q4tk6fd	340	1	In	in	IN
cord-310268-8q4tk6fd	340	2	vitro	vitro	FW
cord-310268-8q4tk6fd	340	3	selection	selection	NN
cord-310268-8q4tk6fd	340	4	of	of	IN
cord-310268-8q4tk6fd	340	5	DNA	dna	NN
cord-310268-8q4tk6fd	340	6	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	340	7	to	to	IN
cord-310268-8q4tk6fd	340	8	anthrax	anthrax	NN
cord-310268-8q4tk6fd	340	9	spores	spore	NNS
cord-310268-8q4tk6fd	340	10	with	with	IN
cord-310268-8q4tk6fd	340	11	electrochemiluminescence	electrochemiluminescence	NN
cord-310268-8q4tk6fd	340	12	detection	detection	NN
cord-310268-8q4tk6fd	340	13	DNA	DNA	NNP
cord-310268-8q4tk6fd	340	14	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	341	1	Selected	select	VBN
cord-310268-8q4tk6fd	341	2	against	against	IN
cord-310268-8q4tk6fd	341	3	Pancreatic	Pancreatic	NNP
cord-310268-8q4tk6fd	341	4	Ductal	Ductal	NNP
cord-310268-8q4tk6fd	341	5	Adenocarcinoma	Adenocarcinoma	NNP
cord-310268-8q4tk6fd	341	6	for	for	IN
cord-310268-8q4tk6fd	341	7	in	in	IN
cord-310268-8q4tk6fd	341	8	vivo	vivo	NNP
cord-310268-8q4tk6fd	341	9	Imaging	Imaging	NNP
cord-310268-8q4tk6fd	341	10	and	and	CC
cord-310268-8q4tk6fd	341	11	Clinical	Clinical	NNP
cord-310268-8q4tk6fd	341	12	Tissue	Tissue	NNP
cord-310268-8q4tk6fd	341	13	Recognition	Recognition	NNP
cord-310268-8q4tk6fd	341	14	Cell	Cell	NNP
cord-310268-8q4tk6fd	341	15	-	-	HYPH
cord-310268-8q4tk6fd	341	16	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	341	17	based	base	VBN
cord-310268-8q4tk6fd	341	18	selection	selection	NN
cord-310268-8q4tk6fd	341	19	and	and	CC
cord-310268-8q4tk6fd	341	20	characterization	characterization	NN
cord-310268-8q4tk6fd	341	21	of	of	IN
cord-310268-8q4tk6fd	341	22	DNA	DNA	NNP
cord-310268-8q4tk6fd	341	23	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	341	24	recognizing	recognize	VBG
cord-310268-8q4tk6fd	341	25	human	human	JJ
cord-310268-8q4tk6fd	341	26	hepatocarcinoma	hepatocarcinoma	NNP
cord-310268-8q4tk6fd	341	27	Molecular	Molecular	NNP
cord-310268-8q4tk6fd	341	28	Recognition	Recognition	NNP
cord-310268-8q4tk6fd	341	29	of	of	IN
cord-310268-8q4tk6fd	341	30	Human	Human	NNP
cord-310268-8q4tk6fd	341	31	Liver	Liver	NNP
cord-310268-8q4tk6fd	341	32	Cancer	Cancer	NNP
cord-310268-8q4tk6fd	341	33	Cells	cell	NNS
cord-310268-8q4tk6fd	341	34	Using	use	VBG
cord-310268-8q4tk6fd	341	35	DNA	DNA	NNP
cord-310268-8q4tk6fd	341	36	Aptamers	Aptamers	NNPS
cord-310268-8q4tk6fd	341	37	Generated	generate	VBN
cord-310268-8q4tk6fd	341	38	via	via	IN
cord-310268-8q4tk6fd	342	1	Cell	cell	NN
cord-310268-8q4tk6fd	342	2	-	-	HYPH
cord-310268-8q4tk6fd	342	3	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	342	4	Cell	Cell	NNP
cord-310268-8q4tk6fd	342	5	-	-	HYPH
cord-310268-8q4tk6fd	342	6	SELEX	SELEX	NNP
cord-310268-8q4tk6fd	342	7	based	base	VBN
cord-310268-8q4tk6fd	342	8	selection	selection	NN
cord-310268-8q4tk6fd	342	9	and	and	CC
cord-310268-8q4tk6fd	342	10	optimization	optimization	NN
cord-310268-8q4tk6fd	342	11	of	of	IN
cord-310268-8q4tk6fd	342	12	DNA	dna	NN
cord-310268-8q4tk6fd	342	13	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	342	14	for	for	IN
cord-310268-8q4tk6fd	342	15	specific	specific	JJ
cord-310268-8q4tk6fd	342	16	recognition	recognition	NN
cord-310268-8q4tk6fd	342	17	of	of	IN
cord-310268-8q4tk6fd	342	18	human	human	JJ
cord-310268-8q4tk6fd	342	19	cholangiocarcinoma	cholangiocarcinoma	NNS
cord-310268-8q4tk6fd	343	1	QBC-939	QBC-939	NNP
cord-310268-8q4tk6fd	343	2	cells	cell	NNS
cord-310268-8q4tk6fd	344	1	A	a	DT
cord-310268-8q4tk6fd	344	2	cell	cell	NN
cord-310268-8q4tk6fd	344	3	-	-	HYPH
cord-310268-8q4tk6fd	344	4	based	base	VBN
cord-310268-8q4tk6fd	344	5	single	single	RB
cord-310268-8q4tk6fd	344	6	-	-	HYPH
cord-310268-8q4tk6fd	344	7	stranded	strand	VBN
cord-310268-8q4tk6fd	344	8	DNA	DNA	NNP
cord-310268-8q4tk6fd	344	9	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	344	10	specifically	specifically	RB
cord-310268-8q4tk6fd	344	11	targets	target	VBZ
cord-310268-8q4tk6fd	344	12	gastric	gastric	JJ
cord-310268-8q4tk6fd	344	13	cancer	cancer	NN
cord-310268-8q4tk6fd	344	14	A	a	DT
cord-310268-8q4tk6fd	344	15	DNA	dna	NN
cord-310268-8q4tk6fd	344	16	aptamer	aptamer	NN
cord-310268-8q4tk6fd	344	17	with	with	IN
cord-310268-8q4tk6fd	344	18	high	high	JJ
cord-310268-8q4tk6fd	344	19	affinity	affinity	NN
cord-310268-8q4tk6fd	344	20	and	and	CC
cord-310268-8q4tk6fd	344	21	specificity	specificity	NN
cord-310268-8q4tk6fd	344	22	for	for	IN
cord-310268-8q4tk6fd	344	23	molecular	molecular	JJ
cord-310268-8q4tk6fd	344	24	recognition	recognition	NN
cord-310268-8q4tk6fd	344	25	and	and	CC
cord-310268-8q4tk6fd	344	26	targeting	target	VBG
cord-310268-8q4tk6fd	344	27	therapy	therapy	NN
cord-310268-8q4tk6fd	344	28	of	of	IN
cord-310268-8q4tk6fd	344	29	gastric	gastric	JJ
cord-310268-8q4tk6fd	344	30	cancer	cancer	NN
cord-310268-8q4tk6fd	345	1	In	in	IN
cord-310268-8q4tk6fd	345	2	Vitro	Vitro	NNP
cord-310268-8q4tk6fd	345	3	Selection	Selection	NNP
cord-310268-8q4tk6fd	345	4	of	of	IN
cord-310268-8q4tk6fd	345	5	DNA	DNA	NNP
cord-310268-8q4tk6fd	345	6	Aptamers	Aptamers	NNP
cord-310268-8q4tk6fd	345	7	for	for	IN
cord-310268-8q4tk6fd	345	8	Metastatic	Metastatic	NNP
cord-310268-8q4tk6fd	345	9	Breast	Breast	NNP
cord-310268-8q4tk6fd	345	10	Cancer	Cancer	NNP
cord-310268-8q4tk6fd	345	11	Cell	Cell	NNP
cord-310268-8q4tk6fd	345	12	Recognition	Recognition	NNP
cord-310268-8q4tk6fd	345	13	and	and	CC
cord-310268-8q4tk6fd	345	14	Tissue	Tissue	NNP
cord-310268-8q4tk6fd	345	15	Imaging	Imaging	NNP
cord-310268-8q4tk6fd	345	16	Selection	Selection	NNP
cord-310268-8q4tk6fd	345	17	of	of	IN
cord-310268-8q4tk6fd	345	18	DNA	DNA	NNP
cord-310268-8q4tk6fd	345	19	Aptamers	Aptamers	NNP
cord-310268-8q4tk6fd	345	20	against	against	IN
cord-310268-8q4tk6fd	345	21	Glioblastoma	Glioblastoma	NNP
cord-310268-8q4tk6fd	345	22	Cells	cell	NNS
cord-310268-8q4tk6fd	345	23	with	with	IN
cord-310268-8q4tk6fd	345	24	High	High	NNP
cord-310268-8q4tk6fd	345	25	Affinity	Affinity	NNP
cord-310268-8q4tk6fd	345	26	and	and	CC
cord-310268-8q4tk6fd	345	27	Specificity	Specificity	NNP
cord-310268-8q4tk6fd	345	28	DNA	DNA	NNP
cord-310268-8q4tk6fd	345	29	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	345	30	that	that	WDT
cord-310268-8q4tk6fd	345	31	target	target	VBP
cord-310268-8q4tk6fd	345	32	human	human	JJ
cord-310268-8q4tk6fd	345	33	glioblastoma	glioblastoma	NN
cord-310268-8q4tk6fd	345	34	multiforme	multiforme	NN
cord-310268-8q4tk6fd	345	35	cells	cell	NNS
cord-310268-8q4tk6fd	345	36	overexpressing	overexpresse	VBG
cord-310268-8q4tk6fd	345	37	epidermal	epidermal	JJ
cord-310268-8q4tk6fd	345	38	growth	growth	NN
cord-310268-8q4tk6fd	345	39	factor	factor	NN
cord-310268-8q4tk6fd	345	40	receptor	receptor	NN
cord-310268-8q4tk6fd	345	41	variant	variant	NN
cord-310268-8q4tk6fd	345	42	III	III	NNP
cord-310268-8q4tk6fd	345	43	in	in	IN
cord-310268-8q4tk6fd	345	44	vitro	vitro	FW
cord-310268-8q4tk6fd	345	45	Selection	selection	NN
cord-310268-8q4tk6fd	345	46	of	of	IN
cord-310268-8q4tk6fd	345	47	DNA	DNA	NNP
cord-310268-8q4tk6fd	345	48	Aptamers	Aptamers	NNP
cord-310268-8q4tk6fd	345	49	against	against	IN
cord-310268-8q4tk6fd	345	50	Epithelial	epithelial	JJ
cord-310268-8q4tk6fd	345	51	Cell	cell	NN
cord-310268-8q4tk6fd	345	52	Adhesion	adhesion	NN
cord-310268-8q4tk6fd	345	53	Molecule	Molecule	NNP
cord-310268-8q4tk6fd	345	54	for	for	IN
cord-310268-8q4tk6fd	345	55	Cancer	Cancer	NNP
cord-310268-8q4tk6fd	345	56	Cell	Cell	NNP
cord-310268-8q4tk6fd	345	57	Imaging	Imaging	NNP
cord-310268-8q4tk6fd	345	58	and	and	CC
cord-310268-8q4tk6fd	345	59	Circulating	circulate	VBG
cord-310268-8q4tk6fd	345	60	Tumor	tumor	NN
cord-310268-8q4tk6fd	345	61	Cell	cell	NN
cord-310268-8q4tk6fd	345	62	Capture	capture	NN
cord-310268-8q4tk6fd	345	63	Probing	probe	VBG
cord-310268-8q4tk6fd	345	64	high	high	JJ
cord-310268-8q4tk6fd	345	65	affinity	affinity	NN
cord-310268-8q4tk6fd	345	66	sequences	sequence	NNS
cord-310268-8q4tk6fd	345	67	of	of	IN
cord-310268-8q4tk6fd	345	68	DNA	DNA	NNP
cord-310268-8q4tk6fd	345	69	aptamer	aptamer	NN
cord-310268-8q4tk6fd	345	70	against	against	IN
cord-310268-8q4tk6fd	345	71	VEGF165	VEGF165	NNP
cord-310268-8q4tk6fd	345	72	Selection	Selection	NNP
cord-310268-8q4tk6fd	345	73	of	of	IN
cord-310268-8q4tk6fd	345	74	DNA	dna	NN
cord-310268-8q4tk6fd	345	75	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	345	76	against	against	IN
cord-310268-8q4tk6fd	345	77	VEGF(165	VEGF(165	NNS
cord-310268-8q4tk6fd	345	78	)	)	-RRB-
cord-310268-8q4tk6fd	345	79	using	use	VBG
cord-310268-8q4tk6fd	345	80	a	a	DT
cord-310268-8q4tk6fd	345	81	protein	protein	NN
cord-310268-8q4tk6fd	345	82	competitor	competitor	NN
cord-310268-8q4tk6fd	345	83	and	and	CC
cord-310268-8q4tk6fd	345	84	the	the	DT
cord-310268-8q4tk6fd	345	85	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	345	86	blotting	blotting	NN
cord-310268-8q4tk6fd	345	87	method	method	NN
cord-310268-8q4tk6fd	346	1	In	in	IN
cord-310268-8q4tk6fd	346	2	Vitro	Vitro	NNP
cord-310268-8q4tk6fd	346	3	Selection	Selection	NNP
cord-310268-8q4tk6fd	346	4	of	of	IN
cord-310268-8q4tk6fd	346	5	DNA	DNA	NNP
cord-310268-8q4tk6fd	346	6	Aptamers	Aptamers	NNPS
cord-310268-8q4tk6fd	346	7	to	to	IN
cord-310268-8q4tk6fd	346	8	Glioblastoma	Glioblastoma	NNP
cord-310268-8q4tk6fd	346	9	Multiforme	Multiforme	NNP
cord-310268-8q4tk6fd	346	10	Selection	Selection	NNP
cord-310268-8q4tk6fd	346	11	and	and	CC
cord-310268-8q4tk6fd	346	12	characterization	characterization	NN
cord-310268-8q4tk6fd	346	13	of	of	IN
cord-310268-8q4tk6fd	346	14	DNA	dna	NN
cord-310268-8q4tk6fd	346	15	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	346	16	for	for	IN
cord-310268-8q4tk6fd	346	17	use	use	NN
cord-310268-8q4tk6fd	346	18	in	in	IN
cord-310268-8q4tk6fd	346	19	detection	detection	NN
cord-310268-8q4tk6fd	346	20	of	of	IN
cord-310268-8q4tk6fd	346	21	avian	avian	JJ
cord-310268-8q4tk6fd	346	22	influenza	influenza	NN
cord-310268-8q4tk6fd	346	23	virus	virus	NN
cord-310268-8q4tk6fd	346	24	H5N1	H5N1	NNP
cord-310268-8q4tk6fd	346	25	Development	Development	NNP
cord-310268-8q4tk6fd	346	26	of	of	IN
cord-310268-8q4tk6fd	346	27	a	a	DT
cord-310268-8q4tk6fd	346	28	fluorescent	fluorescent	JJ
cord-310268-8q4tk6fd	346	29	enzyme	enzyme	NN
cord-310268-8q4tk6fd	346	30	-	-	HYPH
cord-310268-8q4tk6fd	346	31	linked	link	VBN
cord-310268-8q4tk6fd	346	32	DNA	dna	NN
cord-310268-8q4tk6fd	346	33	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	346	34	-	-	HYPH
cord-310268-8q4tk6fd	346	35	magnetic	magnetic	JJ
cord-310268-8q4tk6fd	346	36	bead	bead	NN
cord-310268-8q4tk6fd	346	37	sandwich	sandwich	NN
cord-310268-8q4tk6fd	346	38	assay	assay	NN
cord-310268-8q4tk6fd	346	39	and	and	CC
cord-310268-8q4tk6fd	346	40	portable	portable	JJ
cord-310268-8q4tk6fd	346	41	fluorometer	fluorometer	NN
cord-310268-8q4tk6fd	346	42	for	for	IN
cord-310268-8q4tk6fd	346	43	sensitive	sensitive	JJ
cord-310268-8q4tk6fd	346	44	and	and	CC
cord-310268-8q4tk6fd	346	45	rapid	rapid	JJ
cord-310268-8q4tk6fd	346	46	leishmania	leishmania	NN
cord-310268-8q4tk6fd	346	47	detection	detection	NN
cord-310268-8q4tk6fd	346	48	in	in	IN
cord-310268-8q4tk6fd	346	49	sandflies	sandfly	NNS
cord-310268-8q4tk6fd	346	50	Label	label	VB
cord-310268-8q4tk6fd	346	51	-	-	HYPH
cord-310268-8q4tk6fd	346	52	free	free	JJ
cord-310268-8q4tk6fd	346	53	detection	detection	NN
cord-310268-8q4tk6fd	346	54	of	of	IN
cord-310268-8q4tk6fd	346	55	prion	prion	NN
cord-310268-8q4tk6fd	346	56	protein	protein	NN
cord-310268-8q4tk6fd	346	57	with	with	IN
cord-310268-8q4tk6fd	346	58	its	-PRON-	PRP$
cord-310268-8q4tk6fd	346	59	DNA	DNA	NNP
cord-310268-8q4tk6fd	346	60	aptamer	aptamer	NN
cord-310268-8q4tk6fd	346	61	through	through	IN
cord-310268-8q4tk6fd	346	62	the	the	DT
cord-310268-8q4tk6fd	346	63	formation	formation	NN
cord-310268-8q4tk6fd	346	64	of	of	IN
cord-310268-8q4tk6fd	346	65	T	T	NNP
cord-310268-8q4tk6fd	346	66	-	-	HYPH
cord-310268-8q4tk6fd	346	67	Hg2	Hg2	NNP
cord-310268-8q4tk6fd	346	68	+	+	SYM
cord-310268-8q4tk6fd	346	69	-T	-T	:
cord-310268-8q4tk6fd	346	70	configuration	configuration	NN
cord-310268-8q4tk6fd	346	71	Application	application	NN
cord-310268-8q4tk6fd	346	72	of	of	IN
cord-310268-8q4tk6fd	346	73	a	a	DT
cord-310268-8q4tk6fd	346	74	novel	novel	NN
cord-310268-8q4tk6fd	346	75	in	in	IN
cord-310268-8q4tk6fd	346	76	vitro	vitro	FW
cord-310268-8q4tk6fd	346	77	selection	selection	NN
cord-310268-8q4tk6fd	346	78	technique	technique	NN
cord-310268-8q4tk6fd	346	79	to	to	TO
cord-310268-8q4tk6fd	346	80	isolate	isolate	VB
cord-310268-8q4tk6fd	346	81	and	and	CC
cord-310268-8q4tk6fd	346	82	characterise	characterise	VB
cord-310268-8q4tk6fd	346	83	high	high	JJ
cord-310268-8q4tk6fd	346	84	affinity	affinity	NN
cord-310268-8q4tk6fd	346	85	DNA	dna	NN
cord-310268-8q4tk6fd	346	86	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	346	87	binding	bind	VBG
cord-310268-8q4tk6fd	346	88	mammalian	mammalian	JJ
cord-310268-8q4tk6fd	346	89	prion	prion	NN
cord-310268-8q4tk6fd	346	90	proteins	protein	NNS
cord-310268-8q4tk6fd	346	91	Structural	structural	JJ
cord-310268-8q4tk6fd	346	92	basis	basis	NN
cord-310268-8q4tk6fd	346	93	for	for	IN
cord-310268-8q4tk6fd	346	94	discriminatory	discriminatory	JJ
cord-310268-8q4tk6fd	346	95	recognition	recognition	NN
cord-310268-8q4tk6fd	346	96	of	of	IN
cord-310268-8q4tk6fd	346	97	Plasmodium	plasmodium	NN
cord-310268-8q4tk6fd	346	98	lactate	lactate	NN
cord-310268-8q4tk6fd	346	99	dehydrogenase	dehydrogenase	NN
cord-310268-8q4tk6fd	346	100	by	by	IN
cord-310268-8q4tk6fd	346	101	a	a	DT
cord-310268-8q4tk6fd	346	102	DNA	DNA	NNP
cord-310268-8q4tk6fd	346	103	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	346	104	Screening	screening	NN
cord-310268-8q4tk6fd	346	105	of	of	IN
cord-310268-8q4tk6fd	346	106	DNA	DNA	NNP
cord-310268-8q4tk6fd	346	107	Aptamers	Aptamers	NNP
cord-310268-8q4tk6fd	346	108	against	against	IN
cord-310268-8q4tk6fd	346	109	Myoglobin	myoglobin	NN
cord-310268-8q4tk6fd	346	110	Using	use	VBG
cord-310268-8q4tk6fd	346	111	a	a	DT
cord-310268-8q4tk6fd	346	112	Positive	positive	JJ
cord-310268-8q4tk6fd	346	113	and	and	CC
cord-310268-8q4tk6fd	346	114	Negative	negative	JJ
cord-310268-8q4tk6fd	346	115	Selection	Selection	NNP
cord-310268-8q4tk6fd	346	116	Units	Units	NNPS
cord-310268-8q4tk6fd	346	117	Integrated	Integrated	NNP
cord-310268-8q4tk6fd	346	118	Microfluidic	Microfluidic	NNP
cord-310268-8q4tk6fd	346	119	Chip	Chip	NNP
cord-310268-8q4tk6fd	346	120	and	and	CC
cord-310268-8q4tk6fd	346	121	Its	-PRON-	PRP$
cord-310268-8q4tk6fd	346	122	Biosensing	Biosensing	NNP
cord-310268-8q4tk6fd	346	123	Application	Application	NNP
cord-310268-8q4tk6fd	346	124	Development	Development	NNP
cord-310268-8q4tk6fd	346	125	of	of	IN
cord-310268-8q4tk6fd	346	126	a	a	DT
cord-310268-8q4tk6fd	346	127	DNA	dna	NN
cord-310268-8q4tk6fd	346	128	aptamer	aptamer	NN
cord-310268-8q4tk6fd	346	129	for	for	IN
cord-310268-8q4tk6fd	346	130	direct	direct	JJ
cord-310268-8q4tk6fd	346	131	and	and	CC
cord-310268-8q4tk6fd	346	132	selective	selective	JJ
cord-310268-8q4tk6fd	346	133	homocysteine	homocysteine	JJ
cord-310268-8q4tk6fd	346	134	detection	detection	NN
cord-310268-8q4tk6fd	346	135	in	in	IN
cord-310268-8q4tk6fd	346	136	human	human	JJ
cord-310268-8q4tk6fd	346	137	serum	serum	NN
cord-310268-8q4tk6fd	346	138	DNA	DNA	NNP
cord-310268-8q4tk6fd	346	139	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	346	140	-	-	HYPH
cord-310268-8q4tk6fd	346	141	based	base	VBN
cord-310268-8q4tk6fd	346	142	detection	detection	NN
cord-310268-8q4tk6fd	346	143	of	of	IN
cord-310268-8q4tk6fd	346	144	prostate	prostate	NN
cord-310268-8q4tk6fd	346	145	cancer	cancer	NN
cord-310268-8q4tk6fd	346	146	DNA	dna	NN
cord-310268-8q4tk6fd	346	147	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	346	148	against	against	IN
cord-310268-8q4tk6fd	346	149	the	the	DT
cord-310268-8q4tk6fd	346	150	MUC1	MUC1	NNP
cord-310268-8q4tk6fd	346	151	tumour	tumour	NN
cord-310268-8q4tk6fd	346	152	marker	marker	NN
cord-310268-8q4tk6fd	346	153	:	:	:
cord-310268-8q4tk6fd	346	154	Design	design	NN
cord-310268-8q4tk6fd	346	155	of	of	IN
cord-310268-8q4tk6fd	346	156	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	346	157	-	-	HYPH
cord-310268-8q4tk6fd	346	158	antibody	antibody	NN
cord-310268-8q4tk6fd	346	159	sandwich	sandwich	NN
cord-310268-8q4tk6fd	346	160	ELISA	ELISA	NNP
cord-310268-8q4tk6fd	346	161	for	for	IN
cord-310268-8q4tk6fd	346	162	the	the	DT
cord-310268-8q4tk6fd	346	163	early	early	JJ
cord-310268-8q4tk6fd	346	164	diagnosis	diagnosis	NN
cord-310268-8q4tk6fd	346	165	of	of	IN
cord-310268-8q4tk6fd	346	166	epithelial	epithelial	JJ
cord-310268-8q4tk6fd	346	167	tumours	tumour	NNS
cord-310268-8q4tk6fd	346	168	Sensitive	sensitive	JJ
cord-310268-8q4tk6fd	346	169	point	point	NN
cord-310268-8q4tk6fd	346	170	-	-	HYPH
cord-310268-8q4tk6fd	346	171	of	of	IN
cord-310268-8q4tk6fd	346	172	-	-	HYPH
cord-310268-8q4tk6fd	346	173	care	care	NN
cord-310268-8q4tk6fd	346	174	monitoring	monitoring	NN
cord-310268-8q4tk6fd	346	175	of	of	IN
cord-310268-8q4tk6fd	346	176	cardiac	cardiac	JJ
cord-310268-8q4tk6fd	346	177	biomarker	biomarker	NN
cord-310268-8q4tk6fd	346	178	myoglobin	myoglobin	NN
cord-310268-8q4tk6fd	346	179	using	use	VBG
cord-310268-8q4tk6fd	346	180	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	346	181	and	and	CC
cord-310268-8q4tk6fd	346	182	ubiquitous	ubiquitous	JJ
cord-310268-8q4tk6fd	346	183	personal	personal	JJ
cord-310268-8q4tk6fd	346	184	glucose	glucose	NN
cord-310268-8q4tk6fd	346	185	meter	meter	NN
cord-310268-8q4tk6fd	346	186	C	c	NN
cord-310268-8q4tk6fd	346	187	-	-	HYPH
cord-310268-8q4tk6fd	346	188	reactive	reactive	JJ
cord-310268-8q4tk6fd	346	189	protein	protein	NN
cord-310268-8q4tk6fd	346	190	,	,	,
cord-310268-8q4tk6fd	346	191	inflammation	inflammation	NN
cord-310268-8q4tk6fd	346	192	and	and	CC
cord-310268-8q4tk6fd	346	193	coronary	coronary	JJ
cord-310268-8q4tk6fd	346	194	heart	heart	NN
cord-310268-8q4tk6fd	346	195	disease	disease	NN
cord-310268-8q4tk6fd	346	196	DNA	DNA	NNP
cord-310268-8q4tk6fd	346	197	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	346	198	-	-	HYPH
cord-310268-8q4tk6fd	346	199	based	base	VBN
cord-310268-8q4tk6fd	346	200	surface	surface	NN
cord-310268-8q4tk6fd	346	201	plasmon	plasmon	JJ
cord-310268-8q4tk6fd	346	202	resonance	resonance	NN
cord-310268-8q4tk6fd	346	203	sensing	sensing	NN
cord-310268-8q4tk6fd	346	204	of	of	IN
cord-310268-8q4tk6fd	346	205	human	human	JJ
cord-310268-8q4tk6fd	346	206	C	c	NN
cord-310268-8q4tk6fd	346	207	-	-	HYPH
cord-310268-8q4tk6fd	346	208	reactive	reactive	JJ
cord-310268-8q4tk6fd	346	209	protein	protein	NN
cord-310268-8q4tk6fd	346	210	Homocysteine	Homocysteine	NNP
cord-310268-8q4tk6fd	346	211	level	level	NN
cord-310268-8q4tk6fd	346	212	and	and	CC
cord-310268-8q4tk6fd	346	213	coronary	coronary	JJ
cord-310268-8q4tk6fd	346	214	heart	heart	NN
cord-310268-8q4tk6fd	346	215	disease	disease	NN
cord-310268-8q4tk6fd	346	216	incidence	incidence	NN
cord-310268-8q4tk6fd	346	217	:	:	:
cord-310268-8q4tk6fd	346	218	A	a	DT
cord-310268-8q4tk6fd	346	219	systematic	systematic	JJ
cord-310268-8q4tk6fd	346	220	review	review	NN
cord-310268-8q4tk6fd	346	221	and	and	CC
cord-310268-8q4tk6fd	346	222	meta	meta	NNP
cord-310268-8q4tk6fd	346	223	-	-	HYPH
cord-310268-8q4tk6fd	346	224	analysis	analysis	NN
cord-310268-8q4tk6fd	346	225	Thrombin	Thrombin	NNP
cord-310268-8q4tk6fd	346	226	,	,	,
cord-310268-8q4tk6fd	346	227	inflammation	inflammation	NN
cord-310268-8q4tk6fd	346	228	,	,	,
cord-310268-8q4tk6fd	346	229	and	and	CC
cord-310268-8q4tk6fd	346	230	cardiovascular	cardiovascular	JJ
cord-310268-8q4tk6fd	346	231	disease	disease	NN
cord-310268-8q4tk6fd	346	232	:	:	:
cord-310268-8q4tk6fd	347	1	An	an	DT
cord-310268-8q4tk6fd	347	2	epidemiologic	epidemiologic	JJ
cord-310268-8q4tk6fd	347	3	perspective	perspective	NN
cord-310268-8q4tk6fd	347	4	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	347	5	binding	bind	VBG
cord-310268-8q4tk6fd	347	6	assays	assay	NNS
cord-310268-8q4tk6fd	347	7	for	for	IN
cord-310268-8q4tk6fd	347	8	proteins	protein	NNS
cord-310268-8q4tk6fd	347	9	:	:	:
cord-310268-8q4tk6fd	348	1	The	the	DT
cord-310268-8q4tk6fd	348	2	thrombin	thrombin	JJ
cord-310268-8q4tk6fd	348	3	example	example	NN
cord-310268-8q4tk6fd	348	4	-	-	:
cord-310268-8q4tk6fd	348	5	A	a	DT
cord-310268-8q4tk6fd	348	6	review	review	NN
cord-310268-8q4tk6fd	348	7	Design	design	NN
cord-310268-8q4tk6fd	348	8	strategies	strategy	NNS
cord-310268-8q4tk6fd	348	9	for	for	IN
cord-310268-8q4tk6fd	348	10	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	348	11	-	-	HYPH
cord-310268-8q4tk6fd	348	12	based	base	VBN
cord-310268-8q4tk6fd	348	13	biosensors	biosensor	NNS
cord-310268-8q4tk6fd	348	14	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	348	15	-	-	HYPH
cord-310268-8q4tk6fd	348	16	based	base	VBN
cord-310268-8q4tk6fd	348	17	molecular	molecular	JJ
cord-310268-8q4tk6fd	348	18	recognition	recognition	NN
cord-310268-8q4tk6fd	348	19	for	for	IN
cord-310268-8q4tk6fd	348	20	biosensor	biosensor	NN
cord-310268-8q4tk6fd	348	21	development	development	NN
cord-310268-8q4tk6fd	348	22	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	348	23	in	in	IN
cord-310268-8q4tk6fd	348	24	bioanalytical	bioanalytical	JJ
cord-310268-8q4tk6fd	348	25	applications	application	NNS
cord-310268-8q4tk6fd	348	26	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	348	27	-	-	HYPH
cord-310268-8q4tk6fd	348	28	based	base	VBN
cord-310268-8q4tk6fd	348	29	biosensors	biosensor	NNS
cord-310268-8q4tk6fd	348	30	for	for	IN
cord-310268-8q4tk6fd	348	31	biomedical	biomedical	JJ
cord-310268-8q4tk6fd	348	32	diagnostics	diagnostic	NNS
cord-310268-8q4tk6fd	348	33	Structure	Structure	NNP
cord-310268-8q4tk6fd	348	34	-	-	:
cord-310268-8q4tk6fd	348	35	switching	switch	VBG
cord-310268-8q4tk6fd	348	36	signaling	signal	VBG
cord-310268-8q4tk6fd	348	37	aptamers	aptamers	NNP
cord-310268-8q4tk6fd	348	38	Structure	Structure	NNP
cord-310268-8q4tk6fd	348	39	-	-	HYPH
cord-310268-8q4tk6fd	348	40	switching	switch	VBG
cord-310268-8q4tk6fd	348	41	signaling	signal	VBG
cord-310268-8q4tk6fd	348	42	aptamers	aptamer	NNS
cord-310268-8q4tk6fd	348	43	:	:	:
cord-310268-8q4tk6fd	349	1	Transducing	transduce	VBG
cord-310268-8q4tk6fd	349	2	molecular	molecular	JJ
cord-310268-8q4tk6fd	349	3	recognition	recognition	NN
cord-310268-8q4tk6fd	349	4	into	into	IN
cord-310268-8q4tk6fd	349	5	fluorescence	fluorescence	NN
cord-310268-8q4tk6fd	349	6	signaling	signal	VBG
cord-310268-8q4tk6fd	349	7	Enzyme	Enzyme	NNP
cord-310268-8q4tk6fd	349	8	-	-	HYPH
cord-310268-8q4tk6fd	349	9	Linked	link	VBN
cord-310268-8q4tk6fd	349	10	Small	Small	NNP
cord-310268-8q4tk6fd	349	11	-	-	HYPH
cord-310268-8q4tk6fd	349	12	Molecule	molecule	NN
cord-310268-8q4tk6fd	349	13	Detection	detection	NN
cord-310268-8q4tk6fd	349	14	Using	use	VBG
cord-310268-8q4tk6fd	349	15	Split	Split	NNP
cord-310268-8q4tk6fd	349	16	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	349	17	Ligation	Ligation	NNP
cord-310268-8q4tk6fd	349	18	Target	Target	NNP
cord-310268-8q4tk6fd	349	19	-	-	HYPH
cord-310268-8q4tk6fd	349	20	induced	induce	VBN
cord-310268-8q4tk6fd	349	21	conjunction	conjunction	NN
cord-310268-8q4tk6fd	349	22	of	of	IN
cord-310268-8q4tk6fd	349	23	split	split	JJ
cord-310268-8q4tk6fd	349	24	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	349	25	fragments	fragment	NNS
cord-310268-8q4tk6fd	349	26	and	and	CC
cord-310268-8q4tk6fd	349	27	assembly	assembly	NN
cord-310268-8q4tk6fd	349	28	with	with	IN
cord-310268-8q4tk6fd	349	29	a	a	DT
cord-310268-8q4tk6fd	349	30	water	water	NN
cord-310268-8q4tk6fd	349	31	-	-	HYPH
cord-310268-8q4tk6fd	349	32	soluble	soluble	JJ
cord-310268-8q4tk6fd	349	33	conjugated	conjugate	VBN
cord-310268-8q4tk6fd	349	34	polymer	polymer	NN
cord-310268-8q4tk6fd	349	35	for	for	IN
cord-310268-8q4tk6fd	349	36	improved	improved	JJ
cord-310268-8q4tk6fd	349	37	protein	protein	NN
cord-310268-8q4tk6fd	349	38	detection	detection	NN
cord-310268-8q4tk6fd	349	39	An	an	DT
cord-310268-8q4tk6fd	349	40	aptamer	aptamer	RB
cord-310268-8q4tk6fd	349	41	-	-	HYPH
cord-310268-8q4tk6fd	349	42	based	base	VBN
cord-310268-8q4tk6fd	349	43	biosensor	biosensor	NN
cord-310268-8q4tk6fd	349	44	for	for	IN
cord-310268-8q4tk6fd	349	45	sensitive	sensitive	JJ
cord-310268-8q4tk6fd	349	46	thrombin	thrombin	NN
cord-310268-8q4tk6fd	349	47	detection	detection	NN
cord-310268-8q4tk6fd	350	1	The	the	DT
cord-310268-8q4tk6fd	350	2	nucleolin	nucleolin	NN
cord-310268-8q4tk6fd	350	3	targeting	target	VBG
cord-310268-8q4tk6fd	350	4	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	350	5	AS1411	AS1411	NNP
cord-310268-8q4tk6fd	350	6	destabilizes	destabilize	VBZ
cord-310268-8q4tk6fd	350	7	Bcl-2	Bcl-2	NNP
cord-310268-8q4tk6fd	350	8	messenger	messenger	NN
cord-310268-8q4tk6fd	350	9	RNA	RNA	NNP
cord-310268-8q4tk6fd	350	10	in	in	IN
cord-310268-8q4tk6fd	350	11	human	human	JJ
cord-310268-8q4tk6fd	350	12	breast	breast	NN
cord-310268-8q4tk6fd	350	13	cancer	cancer	NN
cord-310268-8q4tk6fd	350	14	cells	cell	NNS
cord-310268-8q4tk6fd	351	1	A	a	DT
cord-310268-8q4tk6fd	351	2	phase	phase	NN
cord-310268-8q4tk6fd	352	1	II	II	NNP
cord-310268-8q4tk6fd	352	2	trial	trial	NN
cord-310268-8q4tk6fd	352	3	of	of	IN
cord-310268-8q4tk6fd	352	4	AS1411	as1411	NN
cord-310268-8q4tk6fd	352	5	(	(	-LRB-
cord-310268-8q4tk6fd	352	6	a	a	DT
cord-310268-8q4tk6fd	352	7	novel	novel	JJ
cord-310268-8q4tk6fd	352	8	nucleolin	nucleolin	NN
cord-310268-8q4tk6fd	352	9	-	-	HYPH
cord-310268-8q4tk6fd	352	10	targeted	target	VBN
cord-310268-8q4tk6fd	352	11	DNA	dna	NN
cord-310268-8q4tk6fd	352	12	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	352	13	)	)	-RRB-
cord-310268-8q4tk6fd	352	14	in	in	IN
cord-310268-8q4tk6fd	352	15	metastatic	metastatic	JJ
cord-310268-8q4tk6fd	352	16	renal	renal	JJ
cord-310268-8q4tk6fd	352	17	cell	cell	NN
cord-310268-8q4tk6fd	352	18	carcinoma	carcinoma	NN
cord-310268-8q4tk6fd	352	19	Randomized	randomized	JJ
cord-310268-8q4tk6fd	352	20	phase	phase	NN
cord-310268-8q4tk6fd	352	21	II	ii	CD
cord-310268-8q4tk6fd	352	22	trial	trial	NN
cord-310268-8q4tk6fd	352	23	of	of	IN
cord-310268-8q4tk6fd	352	24	the	the	DT
cord-310268-8q4tk6fd	352	25	nucleolin	nucleolin	NNP
cord-310268-8q4tk6fd	352	26	targeting	target	VBG
cord-310268-8q4tk6fd	352	27	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	352	28	AS1411	as1411	NN
cord-310268-8q4tk6fd	352	29	combined	combine	VBN
cord-310268-8q4tk6fd	352	30	with	with	IN
cord-310268-8q4tk6fd	352	31	high	high	JJ
cord-310268-8q4tk6fd	352	32	-	-	HYPH
cord-310268-8q4tk6fd	352	33	dose	dose	NN
cord-310268-8q4tk6fd	352	34	cytarabine	cytarabine	NN
cord-310268-8q4tk6fd	352	35	in	in	IN
cord-310268-8q4tk6fd	352	36	relapsed	relapse	VBN
cord-310268-8q4tk6fd	352	37	/	/	SYM
cord-310268-8q4tk6fd	352	38	refractory	refractory	JJ
cord-310268-8q4tk6fd	352	39	acute	acute	JJ
cord-310268-8q4tk6fd	352	40	myeloid	myeloid	NN
cord-310268-8q4tk6fd	352	41	leukemia	leukemia	NN
cord-310268-8q4tk6fd	352	42	(	(	-LRB-
cord-310268-8q4tk6fd	352	43	AML	AML	NNP
cord-310268-8q4tk6fd	352	44	)	)	-RRB-
cord-310268-8q4tk6fd	353	1	The	the	DT
cord-310268-8q4tk6fd	353	2	von	von	NNP
cord-310268-8q4tk6fd	353	3	Willebrand	Willebrand	NNP
cord-310268-8q4tk6fd	353	4	inhibitor	inhibitor	NN
cord-310268-8q4tk6fd	354	1	ARC1779	ARC1779	NNP
cord-310268-8q4tk6fd	354	2	reduces	reduce	VBZ
cord-310268-8q4tk6fd	354	3	cerebral	cerebral	JJ
cord-310268-8q4tk6fd	354	4	embolization	embolization	NN
cord-310268-8q4tk6fd	354	5	after	after	IN
cord-310268-8q4tk6fd	354	6	carotid	carotid	NN
cord-310268-8q4tk6fd	354	7	endarterectomy	endarterectomy	NN
cord-310268-8q4tk6fd	354	8	:	:	:
cord-310268-8q4tk6fd	355	1	A	a	DT
cord-310268-8q4tk6fd	355	2	randomized	randomized	JJ
cord-310268-8q4tk6fd	355	3	trial	trial	NN
cord-310268-8q4tk6fd	356	1	A	a	DT
cord-310268-8q4tk6fd	356	2	dose	dose	NN
cord-310268-8q4tk6fd	356	3	ranging	ranging	NN
cord-310268-8q4tk6fd	356	4	phase	phase	NN
cord-310268-8q4tk6fd	357	1	I	I	NNP
cord-310268-8q4tk6fd	357	2	/	/	SYM
cord-310268-8q4tk6fd	357	3	II	II	NNP
cord-310268-8q4tk6fd	357	4	trial	trial	NN
cord-310268-8q4tk6fd	357	5	of	of	IN
cord-310268-8q4tk6fd	357	6	the	the	DT
cord-310268-8q4tk6fd	357	7	von	von	NNP
cord-310268-8q4tk6fd	357	8	Willebrand	Willebrand	NNP
cord-310268-8q4tk6fd	357	9	factor	factor	NN
cord-310268-8q4tk6fd	357	10	inhibiting	inhibit	VBG
cord-310268-8q4tk6fd	357	11	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	358	1	ARC1779	ARC1779	NNP
cord-310268-8q4tk6fd	358	2	in	in	IN
cord-310268-8q4tk6fd	358	3	patients	patient	NNS
cord-310268-8q4tk6fd	358	4	with	with	IN
cord-310268-8q4tk6fd	358	5	congenital	congenital	JJ
cord-310268-8q4tk6fd	358	6	thrombotic	thrombotic	JJ
cord-310268-8q4tk6fd	358	7	thrombocytopenic	thrombocytopenic	JJ
cord-310268-8q4tk6fd	358	8	purpura	purpura	NN
cord-310268-8q4tk6fd	359	1	Emerging	emerge	VBG
cord-310268-8q4tk6fd	359	2	pharmacologic	pharmacologic	JJ
cord-310268-8q4tk6fd	359	3	therapies	therapy	NNS
cord-310268-8q4tk6fd	359	4	for	for	IN
cord-310268-8q4tk6fd	359	5	wet	wet	JJ
cord-310268-8q4tk6fd	359	6	age	age	NN
cord-310268-8q4tk6fd	359	7	-	-	HYPH
cord-310268-8q4tk6fd	359	8	related	relate	VBN
cord-310268-8q4tk6fd	359	9	macular	macular	JJ
cord-310268-8q4tk6fd	359	10	degeneration	degeneration	NN
cord-310268-8q4tk6fd	359	11	AS-1411	AS-1411	NNP
cord-310268-8q4tk6fd	359	12	,	,	,
cord-310268-8q4tk6fd	360	1	a	a	DT
cord-310268-8q4tk6fd	360	2	guanosine	guanosine	JJ
cord-310268-8q4tk6fd	360	3	-	-	HYPH
cord-310268-8q4tk6fd	360	4	rich	rich	JJ
cord-310268-8q4tk6fd	360	5	oligonucleotide	oligonucleotide	JJ
cord-310268-8q4tk6fd	360	6	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	360	7	targeting	target	VBG
cord-310268-8q4tk6fd	360	8	nucleolin	nucleolin	NNP
cord-310268-8q4tk6fd	360	9	for	for	IN
cord-310268-8q4tk6fd	360	10	the	the	DT
cord-310268-8q4tk6fd	360	11	potential	potential	JJ
cord-310268-8q4tk6fd	360	12	treatment	treatment	NN
cord-310268-8q4tk6fd	360	13	of	of	IN
cord-310268-8q4tk6fd	360	14	cancer	cancer	NN
cord-310268-8q4tk6fd	360	15	,	,	,
cord-310268-8q4tk6fd	360	16	including	include	VBG
cord-310268-8q4tk6fd	360	17	acute	acute	JJ
cord-310268-8q4tk6fd	360	18	myeloid	myeloid	JJ
cord-310268-8q4tk6fd	360	19	leukemia	leukemia	NN
cord-310268-8q4tk6fd	360	20	ARC-1779	ARC-1779	NNP
cord-310268-8q4tk6fd	360	21	,	,	,
cord-310268-8q4tk6fd	360	22	a	a	DT
cord-310268-8q4tk6fd	360	23	PEGylated	pegylated	JJ
cord-310268-8q4tk6fd	360	24	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	360	25	antagonist	antagonist	NN
cord-310268-8q4tk6fd	360	26	of	of	IN
cord-310268-8q4tk6fd	360	27	von	von	NNP
cord-310268-8q4tk6fd	360	28	Willebrand	Willebrand	NNP
cord-310268-8q4tk6fd	360	29	factor	factor	NN
cord-310268-8q4tk6fd	360	30	for	for	IN
cord-310268-8q4tk6fd	360	31	potential	potential	JJ
cord-310268-8q4tk6fd	360	32	use	use	NN
cord-310268-8q4tk6fd	360	33	as	as	IN
cord-310268-8q4tk6fd	360	34	an	an	DT
cord-310268-8q4tk6fd	360	35	anticoagulant	anticoagulant	JJ
cord-310268-8q4tk6fd	360	36	or	or	CC
cord-310268-8q4tk6fd	360	37	antithrombotic	antithrombotic	JJ
cord-310268-8q4tk6fd	360	38	agent	agent	NN
cord-310268-8q4tk6fd	360	39	A	a	DT
cord-310268-8q4tk6fd	360	40	DNA	DNA	NNP
cord-310268-8q4tk6fd	360	41	aptamer	aptamer	NN
cord-310268-8q4tk6fd	360	42	prevents	prevent	VBZ
cord-310268-8q4tk6fd	360	43	influenza	influenza	NN
cord-310268-8q4tk6fd	360	44	infection	infection	NN
cord-310268-8q4tk6fd	360	45	by	by	IN
cord-310268-8q4tk6fd	360	46	blocking	block	VBG
cord-310268-8q4tk6fd	360	47	the	the	DT
cord-310268-8q4tk6fd	360	48	receptor	receptor	NN
cord-310268-8q4tk6fd	360	49	binding	bind	VBG
cord-310268-8q4tk6fd	360	50	region	region	NN
cord-310268-8q4tk6fd	360	51	of	of	IN
cord-310268-8q4tk6fd	360	52	the	the	DT
cord-310268-8q4tk6fd	360	53	viral	viral	JJ
cord-310268-8q4tk6fd	360	54	hemagglutinin	hemagglutinin	NN
cord-310268-8q4tk6fd	360	55	DNA	dna	NN
cord-310268-8q4tk6fd	360	56	-	-	HYPH
cord-310268-8q4tk6fd	360	57	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	360	58	targeting	target	VBG
cord-310268-8q4tk6fd	360	59	vimentin	vimentin	NNS
cord-310268-8q4tk6fd	360	60	for	for	IN
cord-310268-8q4tk6fd	360	61	tumor	tumor	NN
cord-310268-8q4tk6fd	360	62	therapy	therapy	NN
cord-310268-8q4tk6fd	360	63	in	in	IN
cord-310268-8q4tk6fd	360	64	vivo	vivo	NNP
cord-310268-8q4tk6fd	360	65	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	360	66	to	to	IN
cord-310268-8q4tk6fd	360	67	ErbB-2	ErbB-2	NNP
cord-310268-8q4tk6fd	360	68	/	/	SYM
cord-310268-8q4tk6fd	360	69	HER2	HER2	NNP
cord-310268-8q4tk6fd	360	70	enhances	enhance	VBZ
cord-310268-8q4tk6fd	360	71	degradation	degradation	NN
cord-310268-8q4tk6fd	360	72	of	of	IN
cord-310268-8q4tk6fd	360	73	the	the	DT
cord-310268-8q4tk6fd	360	74	target	target	NN
cord-310268-8q4tk6fd	360	75	and	and	CC
cord-310268-8q4tk6fd	360	76	inhibits	inhibit	VBZ
cord-310268-8q4tk6fd	360	77	tumorigenic	tumorigenic	JJ
cord-310268-8q4tk6fd	360	78	growth	growth	NN
cord-310268-8q4tk6fd	361	1	Remyelination	remyelination	NN
cord-310268-8q4tk6fd	361	2	induced	induce	VBN
cord-310268-8q4tk6fd	361	3	by	by	IN
cord-310268-8q4tk6fd	361	4	a	a	DT
cord-310268-8q4tk6fd	361	5	DNA	DNA	NNP
cord-310268-8q4tk6fd	361	6	aptamer	aptamer	NN
cord-310268-8q4tk6fd	361	7	in	in	IN
cord-310268-8q4tk6fd	361	8	a	a	DT
cord-310268-8q4tk6fd	361	9	mouse	mouse	NN
cord-310268-8q4tk6fd	361	10	model	model	NN
cord-310268-8q4tk6fd	361	11	of	of	IN
cord-310268-8q4tk6fd	361	12	multiple	multiple	JJ
cord-310268-8q4tk6fd	361	13	sclerosis	sclerosis	NN
cord-310268-8q4tk6fd	361	14	Molecular	Molecular	NNP
cord-310268-8q4tk6fd	361	15	assembly	assembly	NN
cord-310268-8q4tk6fd	361	16	of	of	IN
cord-310268-8q4tk6fd	361	17	an	an	DT
cord-310268-8q4tk6fd	361	18	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	361	19	-	-	HYPH
cord-310268-8q4tk6fd	361	20	drug	drug	NN
cord-310268-8q4tk6fd	361	21	conjugate	conjugate	NN
cord-310268-8q4tk6fd	361	22	for	for	IN
cord-310268-8q4tk6fd	361	23	targeted	target	VBN
cord-310268-8q4tk6fd	361	24	drug	drug	NN
cord-310268-8q4tk6fd	361	25	delivery	delivery	NN
cord-310268-8q4tk6fd	361	26	to	to	TO
cord-310268-8q4tk6fd	361	27	tumor	tumor	NN
cord-310268-8q4tk6fd	361	28	cells	cell	NNS
cord-310268-8q4tk6fd	362	1	Automated	automate	VBN
cord-310268-8q4tk6fd	362	2	modular	modular	JJ
cord-310268-8q4tk6fd	362	3	synthesis	synthesis	NN
cord-310268-8q4tk6fd	362	4	of	of	IN
cord-310268-8q4tk6fd	362	5	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	362	6	-	-	HYPH
cord-310268-8q4tk6fd	362	7	drug	drug	NN
cord-310268-8q4tk6fd	362	8	conjugates	conjugate	NNS
cord-310268-8q4tk6fd	362	9	for	for	IN
cord-310268-8q4tk6fd	363	1	targeted	target	VBN
cord-310268-8q4tk6fd	363	2	drug	drug	NN
cord-310268-8q4tk6fd	363	3	delivery	delivery	NN
cord-310268-8q4tk6fd	363	4	Epirubicin	Epirubicin	NNP
cord-310268-8q4tk6fd	363	5	loaded	load	VBD
cord-310268-8q4tk6fd	363	6	super	super	RB
cord-310268-8q4tk6fd	363	7	paramagnetic	paramagnetic	JJ
cord-310268-8q4tk6fd	363	8	iron	iron	NN
cord-310268-8q4tk6fd	363	9	oxide	oxide	NN
cord-310268-8q4tk6fd	363	10	nanoparticle	nanoparticle	NN
cord-310268-8q4tk6fd	363	11	-	-	HYPH
cord-310268-8q4tk6fd	363	12	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	363	13	bioconjugate	bioconjugate	NN
cord-310268-8q4tk6fd	363	14	for	for	IN
cord-310268-8q4tk6fd	363	15	combined	combined	JJ
cord-310268-8q4tk6fd	363	16	colon	colon	NN
cord-310268-8q4tk6fd	363	17	cancer	cancer	NN
cord-310268-8q4tk6fd	363	18	therapy	therapy	NN
cord-310268-8q4tk6fd	363	19	and	and	CC
cord-310268-8q4tk6fd	363	20	imaging	imaging	NN
cord-310268-8q4tk6fd	363	21	in	in	IN
cord-310268-8q4tk6fd	363	22	vivo	vivo	NN
cord-310268-8q4tk6fd	364	1	Dimeric	Dimeric	NNP
cord-310268-8q4tk6fd	364	2	DNA	DNA	NNP
cord-310268-8q4tk6fd	364	3	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	364	4	Complexes	Complexes	NNPS
cord-310268-8q4tk6fd	364	5	for	for	IN
cord-310268-8q4tk6fd	364	6	High	high	JJ
cord-310268-8q4tk6fd	364	7	-	-	HYPH
cord-310268-8q4tk6fd	364	8	capacity	capacity	NN
cord-310268-8q4tk6fd	364	9	-	-	HYPH
cord-310268-8q4tk6fd	364	10	targeted	target	VBN
cord-310268-8q4tk6fd	364	11	Drug	Drug	NNP
cord-310268-8q4tk6fd	364	12	Delivery	Delivery	NNP
cord-310268-8q4tk6fd	364	13	Using	use	VBG
cord-310268-8q4tk6fd	364	14	pH	ph	NN
cord-310268-8q4tk6fd	364	15	-	-	HYPH
cord-310268-8q4tk6fd	364	16	sensitive	sensitive	JJ
cord-310268-8q4tk6fd	365	1	Covalent	Covalent	NNP
cord-310268-8q4tk6fd	365	2	Linkages	Linkages	NNP
cord-310268-8q4tk6fd	365	3	A	a	DT
cord-310268-8q4tk6fd	365	4	controllable	controllable	JJ
cord-310268-8q4tk6fd	365	5	aptamer	aptamer	NN
cord-310268-8q4tk6fd	365	6	-	-	HYPH
cord-310268-8q4tk6fd	365	7	based	base	VBN
cord-310268-8q4tk6fd	365	8	self	self	NN
cord-310268-8q4tk6fd	365	9	-	-	HYPH
cord-310268-8q4tk6fd	365	10	assembled	assemble	VBN
cord-310268-8q4tk6fd	365	11	DNA	dna	NN
cord-310268-8q4tk6fd	365	12	dendrimer	dendrimer	NNP
cord-310268-8q4tk6fd	365	13	for	for	IN
cord-310268-8q4tk6fd	365	14	high	high	JJ
cord-310268-8q4tk6fd	365	15	affinity	affinity	NN
cord-310268-8q4tk6fd	365	16	targeting	targeting	NN
cord-310268-8q4tk6fd	365	17	,	,	,
cord-310268-8q4tk6fd	365	18	bioimaging	bioimaging	NN
cord-310268-8q4tk6fd	365	19	and	and	CC
cord-310268-8q4tk6fd	365	20	drug	drug	NN
cord-310268-8q4tk6fd	365	21	delivery	delivery	NN
cord-310268-8q4tk6fd	366	1	Anticancer	anticancer	JJ
cord-310268-8q4tk6fd	366	2	role	role	NN
cord-310268-8q4tk6fd	366	3	of	of	IN
cord-310268-8q4tk6fd	366	4	MUC1	MUC1	NNP
cord-310268-8q4tk6fd	366	5	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	366	6	-	-	HYPH
cord-310268-8q4tk6fd	366	7	miR-29b	miR-29b	NNP
cord-310268-8q4tk6fd	366	8	chimera	chimera	NN
cord-310268-8q4tk6fd	366	9	in	in	IN
cord-310268-8q4tk6fd	366	10	epithelial	epithelial	JJ
cord-310268-8q4tk6fd	366	11	ovarian	ovarian	JJ
cord-310268-8q4tk6fd	366	12	carcinoma	carcinoma	NN
cord-310268-8q4tk6fd	366	13	cells	cell	NNS
cord-310268-8q4tk6fd	366	14	through	through	IN
cord-310268-8q4tk6fd	366	15	regulation	regulation	NN
cord-310268-8q4tk6fd	366	16	of	of	IN
cord-310268-8q4tk6fd	366	17	PTEN	PTEN	NNP
cord-310268-8q4tk6fd	366	18	methylation	methylation	NN
cord-310268-8q4tk6fd	366	19	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	366	20	-	-	HYPH
cord-310268-8q4tk6fd	366	21	conjugated	conjugate	VBN
cord-310268-8q4tk6fd	366	22	nanomaterials	nanomaterial	NNS
cord-310268-8q4tk6fd	366	23	and	and	CC
cord-310268-8q4tk6fd	366	24	their	-PRON-	PRP$
cord-310268-8q4tk6fd	366	25	applications	application	NNS
cord-310268-8q4tk6fd	366	26	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	366	27	-	-	HYPH
cord-310268-8q4tk6fd	366	28	mediated	mediate	VBN
cord-310268-8q4tk6fd	366	29	targeted	target	VBN
cord-310268-8q4tk6fd	366	30	delivery	delivery	NN
cord-310268-8q4tk6fd	366	31	of	of	IN
cord-310268-8q4tk6fd	366	32	chemotherapeutic	chemotherapeutic	JJ
cord-310268-8q4tk6fd	366	33	drugs	drug	NNS
cord-310268-8q4tk6fd	366	34	and	and	CC
cord-310268-8q4tk6fd	366	35	siRNA	siRNA	NNP
cord-310268-8q4tk6fd	366	36	for	for	IN
cord-310268-8q4tk6fd	366	37	cancer	cancer	NN
cord-310268-8q4tk6fd	366	38	therapy	therapy	NN
cord-310268-8q4tk6fd	367	1	An	an	DT
cord-310268-8q4tk6fd	367	2	AS1411	as1411	NN
cord-310268-8q4tk6fd	367	3	aptamer	aptamer	JJ
cord-310268-8q4tk6fd	367	4	-	-	HYPH
cord-310268-8q4tk6fd	367	5	conjugated	conjugate	VBN
cord-310268-8q4tk6fd	367	6	liposomal	liposomal	NN
cord-310268-8q4tk6fd	367	7	system	system	NN
cord-310268-8q4tk6fd	367	8	containing	contain	VBG
cord-310268-8q4tk6fd	367	9	a	a	DT
cord-310268-8q4tk6fd	367	10	bubble	bubble	NN
cord-310268-8q4tk6fd	367	11	-	-	HYPH
cord-310268-8q4tk6fd	367	12	generating	generate	VBG
cord-310268-8q4tk6fd	367	13	agent	agent	NN
cord-310268-8q4tk6fd	367	14	for	for	IN
cord-310268-8q4tk6fd	367	15	tumor	tumor	NN
cord-310268-8q4tk6fd	367	16	-	-	HYPH
cord-310268-8q4tk6fd	367	17	specific	specific	JJ
cord-310268-8q4tk6fd	367	18	chemotherapy	chemotherapy	NN
cord-310268-8q4tk6fd	367	19	that	that	WDT
cord-310268-8q4tk6fd	367	20	overcomes	overcome	VBZ
cord-310268-8q4tk6fd	367	21	multidrug	multidrug	NN
cord-310268-8q4tk6fd	367	22	resistance	resistance	NN
cord-310268-8q4tk6fd	367	23	DNA	dna	NN
cord-310268-8q4tk6fd	367	24	and	and	CC
cord-310268-8q4tk6fd	367	25	aptamer	aptamer	NNP
cord-310268-8q4tk6fd	367	26	stabilized	stabilize	VBD
cord-310268-8q4tk6fd	367	27	gold	gold	NN
cord-310268-8q4tk6fd	367	28	nanoparticles	nanoparticle	NNS
cord-310268-8q4tk6fd	367	29	for	for	IN
cord-310268-8q4tk6fd	367	30	targeted	target	VBN
cord-310268-8q4tk6fd	367	31	delivery	delivery	NN
cord-310268-8q4tk6fd	367	32	of	of	IN
cord-310268-8q4tk6fd	367	33	anticancer	anticancer	JJ
cord-310268-8q4tk6fd	367	34	therapeutics	therapeutic	NNS
cord-310268-8q4tk6fd	367	35	Cell	cell	NN
cord-310268-8q4tk6fd	367	36	-	-	HYPH
cord-310268-8q4tk6fd	367	37	type	type	NN
cord-310268-8q4tk6fd	367	38	-	-	HYPH
cord-310268-8q4tk6fd	367	39	specific	specific	JJ
cord-310268-8q4tk6fd	367	40	,	,	,
cord-310268-8q4tk6fd	367	41	Aptamer	Aptamer	NNP
cord-310268-8q4tk6fd	367	42	-	-	HYPH
cord-310268-8q4tk6fd	367	43	functionalized	functionalize	VBN
cord-310268-8q4tk6fd	367	44	Agents	agent	NNS
cord-310268-8q4tk6fd	367	45	for	for	IN
cord-310268-8q4tk6fd	367	46	Targeted	Targeted	NNP
cord-310268-8q4tk6fd	367	47	Disease	Disease	NNP
cord-310268-8q4tk6fd	367	48	Therapy	Therapy	NNP
cord-310268-8q4tk6fd	368	1	The	the	DT
cord-310268-8q4tk6fd	368	2	authors	author	NNS
cord-310268-8q4tk6fd	368	3	would	would	MD
cord-310268-8q4tk6fd	368	4	like	like	VB
cord-310268-8q4tk6fd	368	5	to	to	TO
cord-310268-8q4tk6fd	368	6	thank	thank	VB
cord-310268-8q4tk6fd	368	7	the	the	DT
cord-310268-8q4tk6fd	368	8	Nagasaki	Nagasaki	NNP
cord-310268-8q4tk6fd	368	9	University	University	NNP
cord-310268-8q4tk6fd	368	10	for	for	IN
cord-310268-8q4tk6fd	368	11	covering	cover	VBG
cord-310268-8q4tk6fd	368	12	the	the	DT
cord-310268-8q4tk6fd	368	13	cost	cost	NN
cord-310268-8q4tk6fd	368	14	to	to	TO
cord-310268-8q4tk6fd	368	15	publish	publish	VB
cord-310268-8q4tk6fd	368	16	this	this	DT
cord-310268-8q4tk6fd	368	17	paper	paper	NN
cord-310268-8q4tk6fd	368	18	in	in	IN
cord-310268-8q4tk6fd	368	19	open	open	JJ
cord-310268-8q4tk6fd	368	20	access	access	NN
cord-310268-8q4tk6fd	368	21	.	.	.
cord-310268-8q4tk6fd	369	1	The	the	DT
cord-310268-8q4tk6fd	369	2	funder	funder	NN
cord-310268-8q4tk6fd	369	3	had	have	VBD
cord-310268-8q4tk6fd	369	4	no	no	DT
cord-310268-8q4tk6fd	369	5	role	role	NN
cord-310268-8q4tk6fd	369	6	in	in	IN
cord-310268-8q4tk6fd	369	7	decision	decision	NN
cord-310268-8q4tk6fd	369	8	to	to	TO
cord-310268-8q4tk6fd	369	9	publish	publish	VB
cord-310268-8q4tk6fd	369	10	and	and	CC
cord-310268-8q4tk6fd	369	11	preparation	preparation	NN
cord-310268-8q4tk6fd	369	12	of	of	IN
cord-310268-8q4tk6fd	369	13	the	the	DT
cord-310268-8q4tk6fd	369	14	manuscript	manuscript	NN
cord-310268-8q4tk6fd	369	15	.	.	.
cord-310268-8q4tk6fd	370	1	Author	Author	NNP
cord-310268-8q4tk6fd	370	2	Contributions	contribution	NNS
cord-310268-8q4tk6fd	370	3	:	:	:
cord-310268-8q4tk6fd	370	4	MK	MK	NNP
cord-310268-8q4tk6fd	370	5	,	,	,
cord-310268-8q4tk6fd	370	6	QZ	QZ	NNP
cord-310268-8q4tk6fd	370	7	and	and	CC
cord-310268-8q4tk6fd	370	8	GL	GL	NNP
cord-310268-8q4tk6fd	370	9	conceived	conceive	VBD
cord-310268-8q4tk6fd	370	10	the	the	DT
cord-310268-8q4tk6fd	370	11	review	review	NN
cord-310268-8q4tk6fd	370	12	.	.	.
cord-310268-8q4tk6fd	371	1	QZ	QZ	NNP
cord-310268-8q4tk6fd	371	2	and	and	CC
cord-310268-8q4tk6fd	371	3	GL	GL	NNP
cord-310268-8q4tk6fd	371	4	wrote	write	VBD
cord-310268-8q4tk6fd	371	5	the	the	DT
cord-310268-8q4tk6fd	371	6	manuscript	manuscript	NN
cord-310268-8q4tk6fd	371	7	,	,	,
cord-310268-8q4tk6fd	371	8	and	and	CC
cord-310268-8q4tk6fd	371	9	then	then	RB
cord-310268-8q4tk6fd	371	10	MK	MK	NNP
cord-310268-8q4tk6fd	371	11	revised	revise	VBD
cord-310268-8q4tk6fd	371	12	the	the	DT
cord-310268-8q4tk6fd	371	13	manuscript	manuscript	NN
cord-310268-8q4tk6fd	371	14	.	.	.
cord-310268-8q4tk6fd	372	1	The	the	DT
cord-310268-8q4tk6fd	372	2	authors	author	NNS
cord-310268-8q4tk6fd	372	3	declare	declare	VBP
cord-310268-8q4tk6fd	372	4	no	no	DT
cord-310268-8q4tk6fd	372	5	conflict	conflict	NN
cord-310268-8q4tk6fd	372	6	of	of	IN
cord-310268-8q4tk6fd	372	7	interests	interest	NNS
cord-310268-8q4tk6fd	372	8	.	.	.