id	sid	tid	token	lemma	pos
cord-306904-8iteddug	1	1	key	key	JJ
cord-306904-8iteddug	1	2	:	:	:
cord-306904-8iteddug	1	3	cord-306904	cord-306904	NN
cord-306904-8iteddug	1	4	-	-	HYPH
cord-306904-8iteddug	1	5	8iteddug	8iteddug	CD
cord-306904-8iteddug	1	6	authors	author	NNS
cord-306904-8iteddug	1	7	:	:	:
cord-306904-8iteddug	1	8	Uversky	Uversky	NNP
cord-306904-8iteddug	1	9	,	,	,
cord-306904-8iteddug	1	10	Vladimir	Vladimir	NNP
cord-306904-8iteddug	1	11	N	n	CD
cord-306904-8iteddug	1	12	title	title	NN
cord-306904-8iteddug	1	13	:	:	:
cord-306904-8iteddug	1	14	Unreported	unreported	JJ
cord-306904-8iteddug	1	15	intrinsic	intrinsic	JJ
cord-306904-8iteddug	1	16	disorder	disorder	NN
cord-306904-8iteddug	1	17	in	in	IN
cord-306904-8iteddug	1	18	proteins	protein	NNS
cord-306904-8iteddug	1	19	:	:	:
cord-306904-8iteddug	2	1	Building	building	NN
cord-306904-8iteddug	2	2	connections	connection	NNS
cord-306904-8iteddug	2	3	to	to	IN
cord-306904-8iteddug	2	4	the	the	DT
cord-306904-8iteddug	2	5	literature	literature	NN
cord-306904-8iteddug	2	6	on	on	IN
cord-306904-8iteddug	2	7	IDPs	IDPs	NNP
cord-306904-8iteddug	2	8	date	date	NN
cord-306904-8iteddug	3	1	:	:	:
cord-306904-8iteddug	3	2	2014	2014	CD
cord-306904-8iteddug	3	3	-	-	SYM
cord-306904-8iteddug	3	4	12	12	CD
cord-306904-8iteddug	3	5	-	-	SYM
cord-306904-8iteddug	3	6	12	12	CD
cord-306904-8iteddug	3	7	journal	journal	NN
cord-306904-8iteddug	3	8	:	:	:
cord-306904-8iteddug	4	1	Intrinsically	intrinsically	RB
cord-306904-8iteddug	4	2	Disord	Disord	NNP
cord-306904-8iteddug	4	3	Proteins	protein	NNS
cord-306904-8iteddug	4	4	DOI	DOI	NNP
cord-306904-8iteddug	4	5	:	:	:
cord-306904-8iteddug	4	6	10.4161/21690693.2014.970499	10.4161/21690693.2014.970499	NNP
cord-306904-8iteddug	4	7	sha	sha	NNP
cord-306904-8iteddug	4	8	:	:	:
cord-306904-8iteddug	4	9	8fec2036fb2e98cbb9d4f955ce1d5198d1a09b3c	8fec2036fb2e98cbb9d4f955ce1d5198d1a09b3c	CD
cord-306904-8iteddug	4	10	doc_id	doc_id	CD
cord-306904-8iteddug	4	11	:	:	:
cord-306904-8iteddug	4	12	306904	306904	CD
cord-306904-8iteddug	4	13	cord_uid	cord_uid	NN
cord-306904-8iteddug	4	14	:	:	:
cord-306904-8iteddug	5	1	8iteddug	8iteddug	LS
cord-306904-8iteddug	6	1	This	this	DT
cord-306904-8iteddug	6	2	review	review	NN
cord-306904-8iteddug	6	3	opens	open	VBZ
cord-306904-8iteddug	6	4	a	a	DT
cord-306904-8iteddug	6	5	new	new	JJ
cord-306904-8iteddug	6	6	series	series	NN
cord-306904-8iteddug	6	7	entitled	entitle	VBN
cord-306904-8iteddug	6	8	“	"	``
cord-306904-8iteddug	6	9	Unreported	unreported	JJ
cord-306904-8iteddug	6	10	intrinsic	intrinsic	JJ
cord-306904-8iteddug	6	11	disorder	disorder	NN
cord-306904-8iteddug	6	12	in	in	IN
cord-306904-8iteddug	6	13	proteins	protein	NNS
cord-306904-8iteddug	6	14	.	.	.
cord-306904-8iteddug	6	15	”	"	''
cord-306904-8iteddug	7	1	The	the	DT
cord-306904-8iteddug	7	2	goal	goal	NN
cord-306904-8iteddug	7	3	of	of	IN
cord-306904-8iteddug	7	4	this	this	DT
cord-306904-8iteddug	7	5	series	series	NN
cord-306904-8iteddug	7	6	is	be	VBZ
cord-306904-8iteddug	7	7	to	to	TO
cord-306904-8iteddug	7	8	bring	bring	VB
cord-306904-8iteddug	7	9	attention	attention	NN
cord-306904-8iteddug	7	10	of	of	IN
cord-306904-8iteddug	7	11	researchers	researcher	NNS
cord-306904-8iteddug	7	12	to	to	IN
cord-306904-8iteddug	7	13	an	an	DT
cord-306904-8iteddug	7	14	interesting	interesting	JJ
cord-306904-8iteddug	7	15	phenomenon	phenomenon	NN
cord-306904-8iteddug	7	16	of	of	IN
cord-306904-8iteddug	7	17	missed	miss	VBN
cord-306904-8iteddug	7	18	(	(	-LRB-
cord-306904-8iteddug	7	19	or	or	CC
cord-306904-8iteddug	7	20	overlooked	overlook	VBN
cord-306904-8iteddug	7	21	,	,	,
cord-306904-8iteddug	7	22	or	or	CC
cord-306904-8iteddug	7	23	ignored	ignore	VBN
cord-306904-8iteddug	7	24	,	,	,
cord-306904-8iteddug	7	25	or	or	CC
cord-306904-8iteddug	7	26	unreported	unreported	JJ
cord-306904-8iteddug	7	27	)	)	-RRB-
cord-306904-8iteddug	7	28	disorder	disorder	NN
cord-306904-8iteddug	7	29	.	.	.
cord-306904-8iteddug	8	1	This	this	DT
cord-306904-8iteddug	8	2	series	series	NN
cord-306904-8iteddug	8	3	serves	serve	VBZ
cord-306904-8iteddug	8	4	as	as	IN
cord-306904-8iteddug	8	5	a	a	DT
cord-306904-8iteddug	8	6	companion	companion	NN
cord-306904-8iteddug	8	7	to	to	IN
cord-306904-8iteddug	8	8	“	"	``
cord-306904-8iteddug	8	9	Digested	digested	JJ
cord-306904-8iteddug	8	10	Disorder	Disorder	NNP
cord-306904-8iteddug	8	11	”	"	''
cord-306904-8iteddug	8	12	which	which	WDT
cord-306904-8iteddug	8	13	provides	provide	VBZ
cord-306904-8iteddug	8	14	a	a	DT
cord-306904-8iteddug	8	15	quarterly	quarterly	JJ
cord-306904-8iteddug	8	16	review	review	NN
cord-306904-8iteddug	8	17	of	of	IN
cord-306904-8iteddug	8	18	papers	paper	NNS
cord-306904-8iteddug	8	19	on	on	IN
cord-306904-8iteddug	8	20	intrinsically	intrinsically	RB
cord-306904-8iteddug	8	21	disordered	disordered	JJ
cord-306904-8iteddug	8	22	proteins	protein	NNS
cord-306904-8iteddug	8	23	(	(	-LRB-
cord-306904-8iteddug	8	24	IDPs	IDPs	NNP
cord-306904-8iteddug	8	25	)	)	-RRB-
cord-306904-8iteddug	8	26	found	find	VBN
cord-306904-8iteddug	8	27	by	by	IN
cord-306904-8iteddug	8	28	standard	standard	JJ
cord-306904-8iteddug	8	29	literature	literature	NN
cord-306904-8iteddug	8	30	searches	search	NNS
cord-306904-8iteddug	8	31	.	.	.
cord-306904-8iteddug	9	1	The	the	DT
cord-306904-8iteddug	9	2	need	need	NN
cord-306904-8iteddug	9	3	for	for	IN
cord-306904-8iteddug	9	4	this	this	DT
cord-306904-8iteddug	9	5	alternative	alternative	JJ
cord-306904-8iteddug	9	6	series	series	NN
cord-306904-8iteddug	9	7	results	result	NNS
cord-306904-8iteddug	9	8	from	from	IN
cord-306904-8iteddug	9	9	the	the	DT
cord-306904-8iteddug	9	10	observation	observation	NN
cord-306904-8iteddug	9	11	that	that	IN
cord-306904-8iteddug	9	12	there	there	EX
cord-306904-8iteddug	9	13	are	be	VBP
cord-306904-8iteddug	9	14	numerous	numerous	JJ
cord-306904-8iteddug	9	15	publications	publication	NNS
cord-306904-8iteddug	9	16	that	that	WDT
cord-306904-8iteddug	9	17	describe	describe	VBP
cord-306904-8iteddug	9	18	IDPs	IDPs	NNP
cord-306904-8iteddug	9	19	(	(	-LRB-
cord-306904-8iteddug	9	20	or	or	CC
cord-306904-8iteddug	9	21	hybrid	hybrid	JJ
cord-306904-8iteddug	9	22	proteins	protein	NNS
cord-306904-8iteddug	9	23	with	with	IN
cord-306904-8iteddug	9	24	ordered	ordered	JJ
cord-306904-8iteddug	9	25	and	and	CC
cord-306904-8iteddug	9	26	disordered	disordered	JJ
cord-306904-8iteddug	9	27	regions	region	NNS
cord-306904-8iteddug	9	28	)	)	-RRB-
cord-306904-8iteddug	9	29	yet	yet	CC
cord-306904-8iteddug	9	30	fail	fail	VBP
cord-306904-8iteddug	9	31	to	to	TO
cord-306904-8iteddug	9	32	recognize	recognize	VB
cord-306904-8iteddug	9	33	many	many	JJ
cord-306904-8iteddug	9	34	of	of	IN
cord-306904-8iteddug	9	35	the	the	DT
cord-306904-8iteddug	9	36	key	key	JJ
cord-306904-8iteddug	9	37	discoveries	discovery	NNS
cord-306904-8iteddug	9	38	and	and	CC
cord-306904-8iteddug	9	39	publications	publication	NNS
cord-306904-8iteddug	9	40	in	in	IN
cord-306904-8iteddug	9	41	the	the	DT
cord-306904-8iteddug	9	42	IDP	IDP	NNP
cord-306904-8iteddug	9	43	field	field	NN
cord-306904-8iteddug	9	44	.	.	.
cord-306904-8iteddug	10	1	By	by	IN
cord-306904-8iteddug	10	2	ignoring	ignore	VBG
cord-306904-8iteddug	10	3	the	the	DT
cord-306904-8iteddug	10	4	body	body	NN
cord-306904-8iteddug	10	5	of	of	IN
cord-306904-8iteddug	10	6	work	work	NN
cord-306904-8iteddug	10	7	on	on	IN
cord-306904-8iteddug	10	8	IDPs	IDPs	NNP
cord-306904-8iteddug	10	9	,	,	,
cord-306904-8iteddug	10	10	such	such	JJ
cord-306904-8iteddug	10	11	publications	publication	NNS
cord-306904-8iteddug	10	12	often	often	RB
cord-306904-8iteddug	10	13	fail	fail	VBP
cord-306904-8iteddug	10	14	to	to	TO
cord-306904-8iteddug	10	15	relate	relate	VB
cord-306904-8iteddug	10	16	their	-PRON-	PRP$
cord-306904-8iteddug	10	17	findings	finding	NNS
cord-306904-8iteddug	10	18	to	to	IN
cord-306904-8iteddug	10	19	prior	prior	JJ
cord-306904-8iteddug	10	20	discoveries	discovery	NNS
cord-306904-8iteddug	10	21	or	or	CC
cord-306904-8iteddug	10	22	fail	fail	VBP
cord-306904-8iteddug	10	23	to	to	TO
cord-306904-8iteddug	10	24	explore	explore	VB
cord-306904-8iteddug	10	25	the	the	DT
cord-306904-8iteddug	10	26	obvious	obvious	JJ
cord-306904-8iteddug	10	27	implications	implication	NNS
cord-306904-8iteddug	10	28	of	of	IN
cord-306904-8iteddug	10	29	their	-PRON-	PRP$
cord-306904-8iteddug	10	30	work	work	NN
cord-306904-8iteddug	10	31	.	.	.
cord-306904-8iteddug	11	1	Thus	thus	RB
cord-306904-8iteddug	11	2	,	,	,
cord-306904-8iteddug	11	3	the	the	DT
cord-306904-8iteddug	11	4	goal	goal	NN
cord-306904-8iteddug	11	5	of	of	IN
cord-306904-8iteddug	11	6	this	this	DT
cord-306904-8iteddug	11	7	series	series	NN
cord-306904-8iteddug	11	8	is	be	VBZ
cord-306904-8iteddug	11	9	not	not	RB
cord-306904-8iteddug	11	10	only	only	RB
cord-306904-8iteddug	11	11	to	to	TO
cord-306904-8iteddug	11	12	review	review	VB
cord-306904-8iteddug	11	13	these	these	DT
cord-306904-8iteddug	11	14	very	very	RB
cord-306904-8iteddug	11	15	interesting	interesting	JJ
cord-306904-8iteddug	11	16	and	and	CC
cord-306904-8iteddug	11	17	important	important	JJ
cord-306904-8iteddug	11	18	papers	paper	NNS
cord-306904-8iteddug	11	19	,	,	,
cord-306904-8iteddug	11	20	but	but	CC
cord-306904-8iteddug	11	21	also	also	RB
cord-306904-8iteddug	11	22	to	to	TO
cord-306904-8iteddug	11	23	point	point	VB
cord-306904-8iteddug	11	24	out	out	RP
cord-306904-8iteddug	11	25	how	how	WRB
cord-306904-8iteddug	11	26	each	each	DT
cord-306904-8iteddug	11	27	paper	paper	NN
cord-306904-8iteddug	11	28	relates	relate	VBZ
cord-306904-8iteddug	11	29	to	to	IN
cord-306904-8iteddug	11	30	the	the	DT
cord-306904-8iteddug	11	31	IDP	IDP	NNP
cord-306904-8iteddug	11	32	field	field	NN
cord-306904-8iteddug	11	33	and	and	CC
cord-306904-8iteddug	11	34	show	show	VB
cord-306904-8iteddug	11	35	how	how	WRB
cord-306904-8iteddug	11	36	common	common	JJ
cord-306904-8iteddug	11	37	tools	tool	NNS
cord-306904-8iteddug	11	38	in	in	IN
cord-306904-8iteddug	11	39	the	the	DT
cord-306904-8iteddug	11	40	IDP	IDP	NNP
cord-306904-8iteddug	11	41	field	field	NN
cord-306904-8iteddug	11	42	can	can	MD
cord-306904-8iteddug	11	43	readily	readily	RB
cord-306904-8iteddug	11	44	take	take	VB
cord-306904-8iteddug	11	45	the	the	DT
cord-306904-8iteddug	11	46	findings	finding	NNS
cord-306904-8iteddug	11	47	in	in	IN
cord-306904-8iteddug	11	48	new	new	JJ
cord-306904-8iteddug	11	49	directions	direction	NNS
cord-306904-8iteddug	11	50	or	or	CC
cord-306904-8iteddug	11	51	provide	provide	VB
cord-306904-8iteddug	11	52	a	a	DT
cord-306904-8iteddug	11	53	broader	broad	JJR
cord-306904-8iteddug	11	54	context	context	NN
cord-306904-8iteddug	11	55	for	for	IN
cord-306904-8iteddug	11	56	the	the	DT
cord-306904-8iteddug	11	57	reported	report	VBN
cord-306904-8iteddug	11	58	findings	finding	NNS
cord-306904-8iteddug	11	59	.	.	.
cord-306904-8iteddug	12	1	disorder	disorder	NN
cord-306904-8iteddug	12	2	.	.	.
cord-306904-8iteddug	13	1	This	this	DT
cord-306904-8iteddug	13	2	series	series	NN
cord-306904-8iteddug	13	3	serves	serve	VBZ
cord-306904-8iteddug	13	4	as	as	IN
cord-306904-8iteddug	13	5	a	a	DT
cord-306904-8iteddug	13	6	companion	companion	NN
cord-306904-8iteddug	13	7	to	to	IN
cord-306904-8iteddug	13	8	"	"	``
cord-306904-8iteddug	13	9	Digested	digest	VBN
cord-306904-8iteddug	13	10	Disorder	disorder	NN
cord-306904-8iteddug	13	11	"	"	''
cord-306904-8iteddug	13	12	which	which	WDT
cord-306904-8iteddug	13	13	provides	provide	VBZ
cord-306904-8iteddug	13	14	a	a	DT
cord-306904-8iteddug	13	15	quarterly	quarterly	JJ
cord-306904-8iteddug	13	16	review	review	NN
cord-306904-8iteddug	13	17	of	of	IN
cord-306904-8iteddug	13	18	papers	paper	NNS
cord-306904-8iteddug	13	19	on	on	IN
cord-306904-8iteddug	13	20	intrinsically	intrinsically	RB
cord-306904-8iteddug	13	21	disordered	disordered	JJ
cord-306904-8iteddug	13	22	proteins	protein	NNS
cord-306904-8iteddug	13	23	(	(	-LRB-
cord-306904-8iteddug	13	24	IDPs	IDPs	NNP
cord-306904-8iteddug	13	25	)	)	-RRB-
cord-306904-8iteddug	13	26	found	find	VBN
cord-306904-8iteddug	13	27	by	by	IN
cord-306904-8iteddug	13	28	standard	standard	JJ
cord-306904-8iteddug	13	29	literature	literature	NN
cord-306904-8iteddug	13	30	searches	search	NNS
cord-306904-8iteddug	13	31	.	.	.
cord-306904-8iteddug	14	1	The	the	DT
cord-306904-8iteddug	14	2	need	need	NN
cord-306904-8iteddug	14	3	for	for	IN
cord-306904-8iteddug	14	4	this	this	DT
cord-306904-8iteddug	14	5	alternative	alternative	JJ
cord-306904-8iteddug	14	6	series	series	NN
cord-306904-8iteddug	14	7	results	result	NNS
cord-306904-8iteddug	14	8	from	from	IN
cord-306904-8iteddug	14	9	the	the	DT
cord-306904-8iteddug	14	10	observation	observation	NN
cord-306904-8iteddug	14	11	that	that	IN
cord-306904-8iteddug	14	12	there	there	EX
cord-306904-8iteddug	14	13	are	be	VBP
cord-306904-8iteddug	14	14	numerous	numerous	JJ
cord-306904-8iteddug	14	15	publications	publication	NNS
cord-306904-8iteddug	14	16	that	that	WDT
cord-306904-8iteddug	14	17	describe	describe	VBP
cord-306904-8iteddug	14	18	IDPs	IDPs	NNP
cord-306904-8iteddug	14	19	(	(	-LRB-
cord-306904-8iteddug	14	20	or	or	CC
cord-306904-8iteddug	14	21	hybrid	hybrid	JJ
cord-306904-8iteddug	14	22	proteins	protein	NNS
cord-306904-8iteddug	14	23	with	with	IN
cord-306904-8iteddug	14	24	ordered	ordered	JJ
cord-306904-8iteddug	14	25	and	and	CC
cord-306904-8iteddug	14	26	disordered	disordered	JJ
cord-306904-8iteddug	14	27	regions	region	NNS
cord-306904-8iteddug	14	28	)	)	-RRB-
cord-306904-8iteddug	14	29	yet	yet	CC
cord-306904-8iteddug	14	30	fail	fail	VBP
cord-306904-8iteddug	14	31	to	to	TO
cord-306904-8iteddug	14	32	recognize	recognize	VB
cord-306904-8iteddug	14	33	many	many	JJ
cord-306904-8iteddug	14	34	of	of	IN
cord-306904-8iteddug	14	35	the	the	DT
cord-306904-8iteddug	14	36	key	key	JJ
cord-306904-8iteddug	14	37	discoveries	discovery	NNS
cord-306904-8iteddug	14	38	and	and	CC
cord-306904-8iteddug	14	39	publications	publication	NNS
cord-306904-8iteddug	14	40	in	in	IN
cord-306904-8iteddug	14	41	the	the	DT
cord-306904-8iteddug	14	42	IDP	IDP	NNP
cord-306904-8iteddug	14	43	field	field	NN
cord-306904-8iteddug	14	44	.	.	.
cord-306904-8iteddug	15	1	By	by	IN
cord-306904-8iteddug	15	2	ignoring	ignore	VBG
cord-306904-8iteddug	15	3	the	the	DT
cord-306904-8iteddug	15	4	body	body	NN
cord-306904-8iteddug	15	5	of	of	IN
cord-306904-8iteddug	15	6	work	work	NN
cord-306904-8iteddug	15	7	on	on	IN
cord-306904-8iteddug	15	8	IDPs	IDPs	NNP
cord-306904-8iteddug	15	9	,	,	,
cord-306904-8iteddug	15	10	such	such	JJ
cord-306904-8iteddug	15	11	publications	publication	NNS
cord-306904-8iteddug	15	12	often	often	RB
cord-306904-8iteddug	15	13	fail	fail	VBP
cord-306904-8iteddug	15	14	to	to	TO
cord-306904-8iteddug	15	15	relate	relate	VB
cord-306904-8iteddug	15	16	their	-PRON-	PRP$
cord-306904-8iteddug	15	17	findings	finding	NNS
cord-306904-8iteddug	15	18	to	to	IN
cord-306904-8iteddug	15	19	prior	prior	JJ
cord-306904-8iteddug	15	20	discoveries	discovery	NNS
cord-306904-8iteddug	15	21	or	or	CC
cord-306904-8iteddug	15	22	fail	fail	VBP
cord-306904-8iteddug	15	23	to	to	TO
cord-306904-8iteddug	15	24	explore	explore	VB
cord-306904-8iteddug	15	25	the	the	DT
cord-306904-8iteddug	15	26	obvious	obvious	JJ
cord-306904-8iteddug	15	27	implications	implication	NNS
cord-306904-8iteddug	15	28	of	of	IN
cord-306904-8iteddug	15	29	their	-PRON-	PRP$
cord-306904-8iteddug	15	30	work	work	NN
cord-306904-8iteddug	15	31	.	.	.
cord-306904-8iteddug	16	1	Thus	thus	RB
cord-306904-8iteddug	16	2	,	,	,
cord-306904-8iteddug	16	3	the	the	DT
cord-306904-8iteddug	16	4	goal	goal	NN
cord-306904-8iteddug	16	5	of	of	IN
cord-306904-8iteddug	16	6	this	this	DT
cord-306904-8iteddug	16	7	series	series	NN
cord-306904-8iteddug	16	8	is	be	VBZ
cord-306904-8iteddug	16	9	not	not	RB
cord-306904-8iteddug	16	10	only	only	RB
cord-306904-8iteddug	16	11	to	to	TO
cord-306904-8iteddug	16	12	review	review	VB
cord-306904-8iteddug	16	13	these	these	DT
cord-306904-8iteddug	16	14	very	very	RB
cord-306904-8iteddug	16	15	interesting	interesting	JJ
cord-306904-8iteddug	16	16	and	and	CC
cord-306904-8iteddug	16	17	important	important	JJ
cord-306904-8iteddug	16	18	papers	paper	NNS
cord-306904-8iteddug	16	19	,	,	,
cord-306904-8iteddug	16	20	but	but	CC
cord-306904-8iteddug	16	21	also	also	RB
cord-306904-8iteddug	16	22	to	to	TO
cord-306904-8iteddug	16	23	point	point	VB
cord-306904-8iteddug	16	24	out	out	RP
cord-306904-8iteddug	16	25	how	how	WRB
cord-306904-8iteddug	16	26	each	each	DT
cord-306904-8iteddug	16	27	paper	paper	NN
cord-306904-8iteddug	16	28	relates	relate	VBZ
cord-306904-8iteddug	16	29	to	to	IN
cord-306904-8iteddug	16	30	the	the	DT
cord-306904-8iteddug	16	31	IDP	IDP	NNP
cord-306904-8iteddug	16	32	field	field	NN
cord-306904-8iteddug	16	33	and	and	CC
cord-306904-8iteddug	16	34	show	show	VB
cord-306904-8iteddug	16	35	how	how	WRB
cord-306904-8iteddug	16	36	common	common	JJ
cord-306904-8iteddug	16	37	tools	tool	NNS
cord-306904-8iteddug	16	38	in	in	IN
cord-306904-8iteddug	16	39	the	the	DT
cord-306904-8iteddug	16	40	IDP	IDP	NNP
cord-306904-8iteddug	16	41	field	field	NN
cord-306904-8iteddug	16	42	can	can	MD
cord-306904-8iteddug	16	43	readily	readily	RB
cord-306904-8iteddug	16	44	take	take	VB
cord-306904-8iteddug	16	45	the	the	DT
cord-306904-8iteddug	16	46	findings	finding	NNS
cord-306904-8iteddug	16	47	in	in	IN
cord-306904-8iteddug	16	48	new	new	JJ
cord-306904-8iteddug	16	49	directions	direction	NNS
cord-306904-8iteddug	16	50	or	or	CC
cord-306904-8iteddug	16	51	provide	provide	VB
cord-306904-8iteddug	16	52	a	a	DT
cord-306904-8iteddug	16	53	broader	broad	JJR
cord-306904-8iteddug	16	54	context	context	NN
cord-306904-8iteddug	16	55	for	for	IN
cord-306904-8iteddug	16	56	the	the	DT
cord-306904-8iteddug	16	57	reported	report	VBN
cord-306904-8iteddug	16	58	findings	finding	NNS
cord-306904-8iteddug	16	59	.	.	.
cord-306904-8iteddug	17	1	Recent	recent	JJ
cord-306904-8iteddug	17	2	years	year	NNS
cord-306904-8iteddug	17	3	evidence	evidence	VBP
cord-306904-8iteddug	17	4	an	an	DT
cord-306904-8iteddug	17	5	exponential	exponential	JJ
cord-306904-8iteddug	17	6	increase	increase	NN
cord-306904-8iteddug	17	7	in	in	IN
cord-306904-8iteddug	17	8	the	the	DT
cord-306904-8iteddug	17	9	number	number	NN
cord-306904-8iteddug	17	10	of	of	IN
cord-306904-8iteddug	17	11	papers	paper	NNS
cord-306904-8iteddug	17	12	on	on	IN
cord-306904-8iteddug	17	13	intrinsically	intrinsically	RB
cord-306904-8iteddug	17	14	disordered	disordered	JJ
cord-306904-8iteddug	17	15	proteins	protein	NNS
cord-306904-8iteddug	17	16	(	(	-LRB-
cord-306904-8iteddug	17	17	IDPs	IDPs	NNP
cord-306904-8iteddug	17	18	)	)	-RRB-
cord-306904-8iteddug	17	19	,	,	,
cord-306904-8iteddug	17	20	indicating	indicate	VBG
cord-306904-8iteddug	17	21	that	that	IN
cord-306904-8iteddug	17	22	the	the	DT
cord-306904-8iteddug	17	23	phenomenon	phenomenon	NN
cord-306904-8iteddug	17	24	of	of	IN
cord-306904-8iteddug	17	25	protein	protein	NN
cord-306904-8iteddug	17	26	intrinsic	intrinsic	JJ
cord-306904-8iteddug	17	27	disorder	disorder	NN
cord-306904-8iteddug	17	28	is	be	VBZ
cord-306904-8iteddug	17	29	becoming	become	VBG
cord-306904-8iteddug	17	30	a	a	DT
cord-306904-8iteddug	17	31	popular	popular	JJ
cord-306904-8iteddug	17	32	research	research	NN
cord-306904-8iteddug	17	33	topic	topic	NN
cord-306904-8iteddug	17	34	.	.	.
cord-306904-8iteddug	18	1	This	this	DT
cord-306904-8iteddug	18	2	point	point	NN
cord-306904-8iteddug	18	3	is	be	VBZ
cord-306904-8iteddug	18	4	also	also	RB
cord-306904-8iteddug	18	5	reflected	reflect	VBN
cord-306904-8iteddug	18	6	in	in	IN
cord-306904-8iteddug	18	7	the	the	DT
cord-306904-8iteddug	18	8	articles	article	NNS
cord-306904-8iteddug	18	9	of	of	IN
cord-306904-8iteddug	18	10	the	the	DT
cord-306904-8iteddug	18	11	"	"	``
cord-306904-8iteddug	18	12	Digested	digested	JJ
cord-306904-8iteddug	18	13	Disorder	Disorder	NNP
cord-306904-8iteddug	18	14	"	"	''
cord-306904-8iteddug	18	15	series	series	NN
cord-306904-8iteddug	18	16	published	publish	VBN
cord-306904-8iteddug	18	17	in	in	IN
cord-306904-8iteddug	18	18	this	this	DT
cord-306904-8iteddug	18	19	journal	journal	NN
cord-306904-8iteddug	18	20	.	.	.
cord-306904-8iteddug	19	1	[	[	-LRB-
cord-306904-8iteddug	19	2	1	1	CD
cord-306904-8iteddug	19	3	]	]	-RRB-
cord-306904-8iteddug	19	4	[	[	-LRB-
cord-306904-8iteddug	19	5	2	2	CD
cord-306904-8iteddug	19	6	]	]	-RRB-
cord-306904-8iteddug	19	7	[	[	-LRB-
cord-306904-8iteddug	19	8	3	3	CD
cord-306904-8iteddug	19	9	]	]	-RRB-
cord-306904-8iteddug	20	1	To	to	TO
cord-306904-8iteddug	20	2	make	make	VB
cord-306904-8iteddug	20	3	this	this	DT
cord-306904-8iteddug	20	4	point	point	NN
cord-306904-8iteddug	20	5	stronger	strong	JJR
cord-306904-8iteddug	20	6	some	some	DT
cord-306904-8iteddug	20	7	interesting	interesting	JJ
cord-306904-8iteddug	20	8	numbers	number	NNS
cord-306904-8iteddug	20	9	are	be	VBP
cord-306904-8iteddug	20	10	provided	provide	VBN
cord-306904-8iteddug	20	11	below	below	RB
cord-306904-8iteddug	20	12	.	.	.
cord-306904-8iteddug	21	1	PubMed	PubMed	NNP
cord-306904-8iteddug	21	2	search	search	NN
cord-306904-8iteddug	21	3	(	(	-LRB-
cord-306904-8iteddug	21	4	as	as	IN
cord-306904-8iteddug	21	5	of	of	IN
cord-306904-8iteddug	21	6	August	August	NNP
cord-306904-8iteddug	21	7	03	03	CD
cord-306904-8iteddug	21	8	,	,	,
cord-306904-8iteddug	21	9	2014	2014	CD
cord-306904-8iteddug	21	10	)	)	-RRB-
cord-306904-8iteddug	21	11	for	for	IN
cord-306904-8iteddug	21	12	(	(	-LRB-
cord-306904-8iteddug	21	13	(	(	-LRB-
cord-306904-8iteddug	21	14	intrinsically	intrinsically	RB
cord-306904-8iteddug	21	15	disordered	disordered	JJ
cord-306904-8iteddug	21	16	)	)	-RRB-
cord-306904-8iteddug	21	17	OR	or	CC
cord-306904-8iteddug	21	18	(	(	-LRB-
cord-306904-8iteddug	21	19	natively	natively	RB
cord-306904-8iteddug	21	20	unfolded	unfold	VBN
cord-306904-8iteddug	21	21	)	)	-RRB-
cord-306904-8iteddug	21	22	OR	or	CC
cord-306904-8iteddug	21	23	(	(	-LRB-
cord-306904-8iteddug	21	24	intrinsically	intrinsically	RB
cord-306904-8iteddug	21	25	unstructured	unstructured	JJ
cord-306904-8iteddug	21	26	)	)	-RRB-
cord-306904-8iteddug	21	27	OR	or	CC
cord-306904-8iteddug	21	28	(	(	-LRB-
cord-306904-8iteddug	21	29	intrinsically	intrinsically	RB
cord-306904-8iteddug	21	30	unfolded	unfold	VBN
cord-306904-8iteddug	21	31	)	)	-RRB-
cord-306904-8iteddug	21	32	OR	or	CC
cord-306904-8iteddug	21	33	(	(	-LRB-
cord-306904-8iteddug	21	34	intrinsically	intrinsically	RB
cord-306904-8iteddug	21	35	flexible	flexible	JJ
cord-306904-8iteddug	21	36	protein	protein	NN
cord-306904-8iteddug	21	37	)	)	-RRB-
cord-306904-8iteddug	21	38	)	)	-RRB-
cord-306904-8iteddug	21	39	returned	return	VBD
cord-306904-8iteddug	21	40	2,490	2,490	CD
cord-306904-8iteddug	21	41	hits	hit	NNS
cord-306904-8iteddug	21	42	.	.	.
cord-306904-8iteddug	22	1	Restricting	restrict	VBG
cord-306904-8iteddug	22	2	this	this	DT
cord-306904-8iteddug	22	3	search	search	NN
cord-306904-8iteddug	22	4	to	to	IN
cord-306904-8iteddug	22	5	the	the	DT
cord-306904-8iteddug	22	6	past	past	JJ
cord-306904-8iteddug	22	7	one	one	CD
cord-306904-8iteddug	22	8	and	and	CC
cord-306904-8iteddug	22	9	a	a	DT
cord-306904-8iteddug	22	10	half	half	NN
cord-306904-8iteddug	22	11	years	year	NNS
cord-306904-8iteddug	22	12	only	only	RB
cord-306904-8iteddug	22	13	(	(	-LRB-
cord-306904-8iteddug	22	14	i.e.	i.e.	FW
cord-306904-8iteddug	22	15	,	,	,
cord-306904-8iteddug	22	16	searching	search	VBG
cord-306904-8iteddug	22	17	for	for	IN
cord-306904-8iteddug	22	18	(	(	-LRB-
cord-306904-8iteddug	22	19	(	(	-LRB-
cord-306904-8iteddug	22	20	intrinsically	intrinsically	RB
cord-306904-8iteddug	22	21	disordered	disordered	JJ
cord-306904-8iteddug	22	22	)	)	-RRB-
cord-306904-8iteddug	22	23	OR	or	CC
cord-306904-8iteddug	22	24	(	(	-LRB-
cord-306904-8iteddug	22	25	natively	natively	RB
cord-306904-8iteddug	22	26	unfolded	unfold	VBN
cord-306904-8iteddug	22	27	)	)	-RRB-
cord-306904-8iteddug	22	28	OR	or	CC
cord-306904-8iteddug	22	29	(	(	-LRB-
cord-306904-8iteddug	22	30	intrinsically	intrinsically	RB
cord-306904-8iteddug	22	31	unstructured	unstructured	JJ
cord-306904-8iteddug	22	32	)	)	-RRB-
cord-306904-8iteddug	22	33	OR	or	CC
cord-306904-8iteddug	22	34	(	(	-LRB-
cord-306904-8iteddug	22	35	intrinsically	intrinsically	RB
cord-306904-8iteddug	22	36	unfolded	unfold	VBN
cord-306904-8iteddug	22	37	)	)	-RRB-
cord-306904-8iteddug	22	38	OR	or	CC
cord-306904-8iteddug	22	39	(	(	-LRB-
cord-306904-8iteddug	22	40	intrinsically	intrinsically	RB
cord-306904-8iteddug	22	41	flexible	flexible	JJ
cord-306904-8iteddug	22	42	protein	protein	NN
cord-306904-8iteddug	22	43	)	)	-RRB-
cord-306904-8iteddug	22	44	)	)	-RRB-
cord-306904-8iteddug	23	1	AND	and	CC
cord-306904-8iteddug	23	2	(	(	-LRB-
cord-306904-8iteddug	23	3	"	"	``
cord-306904-8iteddug	23	4	2013/01/	2013/01/	CD
cord-306904-8iteddug	23	5	01"[Date	01"[date	NN
cord-306904-8iteddug	23	6	-Publication	-publication	NN
cord-306904-8iteddug	23	7	]	]	-RRB-
cord-306904-8iteddug	23	8	:	:	:
cord-306904-8iteddug	24	1	"	"	``
cord-306904-8iteddug	24	2	3000"[Date	3000"[date	CD
cord-306904-8iteddug	24	3	-Publication	-publication	NN
cord-306904-8iteddug	24	4	]	]	-RRB-
cord-306904-8iteddug	24	5	)	)	-RRB-
cord-306904-8iteddug	24	6	)	)	-RRB-
cord-306904-8iteddug	24	7	gives	give	VBZ
cord-306904-8iteddug	24	8	659	659	CD
cord-306904-8iteddug	24	9	hits	hit	NNS
cord-306904-8iteddug	24	10	.	.	.
cord-306904-8iteddug	25	1	Curiously	curiously	RB
cord-306904-8iteddug	25	2	,	,	,
cord-306904-8iteddug	25	3	although	although	IN
cord-306904-8iteddug	25	4	papers	paper	NNS
cord-306904-8iteddug	25	5	on	on	IN
cord-306904-8iteddug	25	6	IDPs	IDPs	NNP
cord-306904-8iteddug	25	7	(	(	-LRB-
cord-306904-8iteddug	25	8	2,490	2,490	CD
cord-306904-8iteddug	25	9	)	)	-RRB-
cord-306904-8iteddug	25	10	constitute	constitute	VBP
cord-306904-8iteddug	25	11	just	just	RB
cord-306904-8iteddug	25	12	0.045	0.045	CD
cord-306904-8iteddug	25	13	%	%	NN
cord-306904-8iteddug	25	14	of	of	IN
cord-306904-8iteddug	25	15	all	all	PDT
cord-306904-8iteddug	25	16	the	the	DT
cord-306904-8iteddug	25	17	protein	protein	NN
cord-306904-8iteddug	25	18	-	-	HYPH
cord-306904-8iteddug	25	19	related	relate	VBN
cord-306904-8iteddug	25	20	papers	paper	NNS
cord-306904-8iteddug	25	21	(	(	-LRB-
cord-306904-8iteddug	25	22	5	5	CD
cord-306904-8iteddug	25	23	,	,	,
cord-306904-8iteddug	25	24	569	569	CD
cord-306904-8iteddug	25	25	,	,	,
cord-306904-8iteddug	25	26	481	481	CD
cord-306904-8iteddug	25	27	)	)	-RRB-
cord-306904-8iteddug	25	28	published	publish	VBN
cord-306904-8iteddug	25	29	during	during	IN
cord-306904-8iteddug	25	30	the	the	DT
cord-306904-8iteddug	25	31	past	past	JJ
cord-306904-8iteddug	25	32	115	115	CD
cord-306904-8iteddug	25	33	years	year	NNS
cord-306904-8iteddug	25	34	,	,	,
cord-306904-8iteddug	25	35	the	the	DT
cord-306904-8iteddug	25	36	fraction	fraction	NN
cord-306904-8iteddug	25	37	of	of	IN
cord-306904-8iteddug	25	38	IDPrelated	idprelated	JJ
cord-306904-8iteddug	25	39	papers	paper	NNS
cord-306904-8iteddug	25	40	increases	increase	VBZ
cord-306904-8iteddug	25	41	to	to	IN
cord-306904-8iteddug	25	42	0.18	0.18	CD
cord-306904-8iteddug	25	43	%	%	NN
cord-306904-8iteddug	25	44	if	if	IN
cord-306904-8iteddug	25	45	only	only	JJ
cord-306904-8iteddug	25	46	publications	publication	NNS
cord-306904-8iteddug	25	47	of	of	IN
cord-306904-8iteddug	25	48	the	the	DT
cord-306904-8iteddug	25	49	past	past	JJ
cord-306904-8iteddug	25	50	year	year	NN
cord-306904-8iteddug	25	51	and	and	CC
cord-306904-8iteddug	25	52	a	a	DT
cord-306904-8iteddug	25	53	half	half	NN
cord-306904-8iteddug	25	54	are	be	VBP
cord-306904-8iteddug	25	55	taken	take	VBN
cord-306904-8iteddug	25	56	into	into	IN
cord-306904-8iteddug	25	57	account	account	NN
cord-306904-8iteddug	25	58	.	.	.
cord-306904-8iteddug	26	1	It	-PRON-	PRP
cord-306904-8iteddug	26	2	is	be	VBZ
cord-306904-8iteddug	26	3	of	of	IN
cord-306904-8iteddug	26	4	interest	interest	NN
cord-306904-8iteddug	26	5	to	to	TO
cord-306904-8iteddug	26	6	compare	compare	VB
cord-306904-8iteddug	26	7	these	these	DT
cord-306904-8iteddug	26	8	trends	trend	NNS
cord-306904-8iteddug	26	9	with	with	IN
cord-306904-8iteddug	26	10	the	the	DT
cord-306904-8iteddug	26	11	related	related	JJ
cord-306904-8iteddug	26	12	tendencies	tendency	NNS
cord-306904-8iteddug	26	13	of	of	IN
cord-306904-8iteddug	26	14	the	the	DT
cord-306904-8iteddug	26	15	research	research	NN
cord-306904-8iteddug	26	16	on	on	IN
cord-306904-8iteddug	26	17	proteins	protein	NNS
cord-306904-8iteddug	26	18	in	in	IN
cord-306904-8iteddug	26	19	general	general	JJ
cord-306904-8iteddug	26	20	.	.	.
cord-306904-8iteddug	27	1	Protein	protein	NN
cord-306904-8iteddug	27	2	-	-	HYPH
cord-306904-8iteddug	27	3	related	relate	VBN
cord-306904-8iteddug	27	4	papers	paper	NNS
cord-306904-8iteddug	27	5	(	(	-LRB-
cord-306904-8iteddug	27	6	5	5	CD
cord-306904-8iteddug	27	7	,	,	,
cord-306904-8iteddug	27	8	569	569	CD
cord-306904-8iteddug	27	9	,	,	,
cord-306904-8iteddug	27	10	481	481	CD
cord-306904-8iteddug	27	11	)	)	-RRB-
cord-306904-8iteddug	27	12	constitute	constitute	VBP
cord-306904-8iteddug	27	13	»	»	$
cord-306904-8iteddug	27	14	23	23	CD
cord-306904-8iteddug	27	15	%	%	NN
cord-306904-8iteddug	27	16	of	of	IN
cord-306904-8iteddug	27	17	all	all	PDT
cord-306904-8iteddug	27	18	the	the	DT
cord-306904-8iteddug	27	19	papers	paper	NNS
cord-306904-8iteddug	27	20	published	publish	VBN
cord-306904-8iteddug	27	21	during	during	IN
cord-306904-8iteddug	27	22	the	the	DT
cord-306904-8iteddug	27	23	past	past	JJ
cord-306904-8iteddug	27	24	115	115	CD
cord-306904-8iteddug	27	25	y	y	NN
cord-306904-8iteddug	27	26	and	and	CC
cord-306904-8iteddug	27	27	annotated	annotate	VBN
cord-306904-8iteddug	27	28	in	in	IN
cord-306904-8iteddug	27	29	PubMed	PubMed	NNP
cord-306904-8iteddug	27	30	(	(	-LRB-
cord-306904-8iteddug	27	31	24	24	CD
cord-306904-8iteddug	27	32	,	,	,
cord-306904-8iteddug	27	33	068	068	CD
cord-306904-8iteddug	27	34	,	,	,
cord-306904-8iteddug	27	35	783	783	CD
cord-306904-8iteddug	27	36	)	)	-RRB-
cord-306904-8iteddug	27	37	.	.	.
cord-306904-8iteddug	28	1	However	however	RB
cord-306904-8iteddug	28	2	,	,	,
cord-306904-8iteddug	28	3	this	this	DT
cord-306904-8iteddug	28	4	number	number	NN
cord-306904-8iteddug	28	5	decreases	decrease	VBZ
cord-306904-8iteddug	28	6	to	to	IN
cord-306904-8iteddug	28	7	»	»	$
cord-306904-8iteddug	28	8	21	21	CD
cord-306904-8iteddug	28	9	%	%	NN
cord-306904-8iteddug	28	10	if	if	IN
cord-306904-8iteddug	28	11	only	only	JJ
cord-306904-8iteddug	28	12	papers	paper	NNS
cord-306904-8iteddug	28	13	published	publish	VBN
cord-306904-8iteddug	28	14	during	during	IN
cord-306904-8iteddug	28	15	the	the	DT
cord-306904-8iteddug	28	16	past	past	JJ
cord-306904-8iteddug	28	17	year	year	NN
cord-306904-8iteddug	28	18	and	and	CC
cord-306904-8iteddug	28	19	a	a	DT
cord-306904-8iteddug	28	20	half	half	NN
cord-306904-8iteddug	28	21	are	be	VBP
cord-306904-8iteddug	28	22	taken	take	VBN
cord-306904-8iteddug	28	23	into	into	IN
cord-306904-8iteddug	28	24	account	account	NN
cord-306904-8iteddug	28	25	(	(	-LRB-
cord-306904-8iteddug	28	26	in	in	IN
cord-306904-8iteddug	28	27	2013	2013	CD
cord-306904-8iteddug	28	28	-	-	SYM
cord-306904-8iteddug	28	29	2014	2014	CD
cord-306904-8iteddug	29	1	,	,	,
cord-306904-8iteddug	29	2	the	the	DT
cord-306904-8iteddug	29	3	overall	overall	JJ
cord-306904-8iteddug	29	4	number	number	NN
cord-306904-8iteddug	29	5	of	of	IN
cord-306904-8iteddug	29	6	published	publish	VBN
cord-306904-8iteddug	29	7	papers	paper	NNS
cord-306904-8iteddug	29	8	is	be	VBZ
cord-306904-8iteddug	29	9	1,719,568	1,719,568	CD
cord-306904-8iteddug	29	10	;	;	:
cord-306904-8iteddug	29	11	the	the	DT
cord-306904-8iteddug	29	12	number	number	NN
cord-306904-8iteddug	29	13	of	of	IN
cord-306904-8iteddug	29	14	papers	paper	NNS
cord-306904-8iteddug	29	15	dealing	deal	VBG
cord-306904-8iteddug	29	16	with	with	IN
cord-306904-8iteddug	29	17	proteins	protein	NNS
cord-306904-8iteddug	29	18	is	be	VBZ
cord-306904-8iteddug	29	19	362,612	362,612	CD
cord-306904-8iteddug	29	20	)	)	-RRB-
cord-306904-8iteddug	29	21	.	.	.
cord-306904-8iteddug	30	1	This	this	DT
cord-306904-8iteddug	30	2	suggests	suggest	VBZ
cord-306904-8iteddug	30	3	that	that	IN
cord-306904-8iteddug	30	4	an	an	DT
cord-306904-8iteddug	30	5	IDP	IDP	NNP
cord-306904-8iteddug	30	6	is	be	VBZ
cord-306904-8iteddug	30	7	a	a	DT
cord-306904-8iteddug	30	8	new	new	JJ
cord-306904-8iteddug	30	9	rising	rise	VBG
cord-306904-8iteddug	30	10	star	star	NN
cord-306904-8iteddug	30	11	in	in	IN
cord-306904-8iteddug	30	12	the	the	DT
cord-306904-8iteddug	30	13	field	field	NN
cord-306904-8iteddug	30	14	of	of	IN
cord-306904-8iteddug	30	15	protein	protein	NN
cord-306904-8iteddug	30	16	science	science	NN
cord-306904-8iteddug	30	17	.	.	.
cord-306904-8iteddug	31	1	Despite	despite	IN
cord-306904-8iteddug	31	2	this	this	DT
cord-306904-8iteddug	31	3	steady	steady	JJ
cord-306904-8iteddug	31	4	and	and	CC
cord-306904-8iteddug	31	5	sure	sure	JJ
cord-306904-8iteddug	31	6	increase	increase	NN
cord-306904-8iteddug	31	7	in	in	IN
cord-306904-8iteddug	31	8	the	the	DT
cord-306904-8iteddug	31	9	appreciation	appreciation	NN
cord-306904-8iteddug	31	10	of	of	IN
cord-306904-8iteddug	31	11	protein	protein	NN
cord-306904-8iteddug	31	12	intrinsic	intrinsic	JJ
cord-306904-8iteddug	31	13	disorder	disorder	NN
cord-306904-8iteddug	31	14	,	,	,
cord-306904-8iteddug	31	15	there	there	EX
cord-306904-8iteddug	31	16	are	be	VBP
cord-306904-8iteddug	31	17	still	still	RB
cord-306904-8iteddug	31	18	numerous	numerous	JJ
cord-306904-8iteddug	31	19	instances	instance	NNS
cord-306904-8iteddug	31	20	when	when	WRB
cord-306904-8iteddug	31	21	this	this	DT
cord-306904-8iteddug	31	22	concept	concept	NN
cord-306904-8iteddug	31	23	is	be	VBZ
cord-306904-8iteddug	31	24	overlooked	overlook	VBN
cord-306904-8iteddug	31	25	,	,	,
cord-306904-8iteddug	31	26	or	or	CC
cord-306904-8iteddug	31	27	missed	miss	VBN
cord-306904-8iteddug	31	28	or	or	CC
cord-306904-8iteddug	31	29	simply	simply	RB
cord-306904-8iteddug	31	30	ignored	ignore	VBN
cord-306904-8iteddug	31	31	.	.	.
cord-306904-8iteddug	32	1	Unfortunately	unfortunately	RB
cord-306904-8iteddug	32	2	,	,	,
cord-306904-8iteddug	32	3	such	such	JJ
cord-306904-8iteddug	32	4	"	"	``
cord-306904-8iteddug	32	5	missed	missed	JJ
cord-306904-8iteddug	32	6	disorder	disorder	NN
cord-306904-8iteddug	32	7	"	"	''
cord-306904-8iteddug	32	8	phenomenon	phenomenon	NN
cord-306904-8iteddug	32	9	continues	continue	VBZ
cord-306904-8iteddug	32	10	to	to	TO
cord-306904-8iteddug	32	11	be	be	VB
cord-306904-8iteddug	32	12	rather	rather	RB
cord-306904-8iteddug	32	13	common	common	JJ
cord-306904-8iteddug	32	14	in	in	IN
cord-306904-8iteddug	32	15	the	the	DT
cord-306904-8iteddug	32	16	modern	modern	JJ
cord-306904-8iteddug	32	17	literature	literature	NN
cord-306904-8iteddug	32	18	.	.	.
cord-306904-8iteddug	33	1	The	the	DT
cord-306904-8iteddug	33	2	original	original	JJ
cord-306904-8iteddug	33	3	goal	goal	NN
cord-306904-8iteddug	33	4	of	of	IN
cord-306904-8iteddug	33	5	the	the	DT
cord-306904-8iteddug	33	6	first	first	JJ
cord-306904-8iteddug	33	7	article	article	NN
cord-306904-8iteddug	33	8	in	in	IN
cord-306904-8iteddug	33	9	the	the	DT
cord-306904-8iteddug	33	10	new	new	JJ
cord-306904-8iteddug	33	11	"	"	``
cord-306904-8iteddug	33	12	Unreported	unreported	JJ
cord-306904-8iteddug	33	13	disorder	disorder	NN
cord-306904-8iteddug	33	14	in	in	IN
cord-306904-8iteddug	33	15	proteins	protein	NNS
cord-306904-8iteddug	33	16	"	"	''
cord-306904-8iteddug	33	17	series	series	NN
cord-306904-8iteddug	33	18	was	be	VBD
cord-306904-8iteddug	33	19	to	to	TO
cord-306904-8iteddug	33	20	find	find	VB
cord-306904-8iteddug	33	21	several	several	JJ
cord-306904-8iteddug	33	22	papers	paper	NNS
cord-306904-8iteddug	33	23	published	publish	VBN
cord-306904-8iteddug	33	24	in	in	IN
cord-306904-8iteddug	33	25	different	different	JJ
cord-306904-8iteddug	33	26	journals	journal	NNS
cord-306904-8iteddug	33	27	that	that	WDT
cord-306904-8iteddug	33	28	talk	talk	VBP
cord-306904-8iteddug	33	29	about	about	IN
cord-306904-8iteddug	33	30	IDPs	IDPs	NNP
cord-306904-8iteddug	33	31	(	(	-LRB-
cord-306904-8iteddug	33	32	or	or	CC
cord-306904-8iteddug	33	33	hybrid	hybrid	JJ
cord-306904-8iteddug	33	34	proteins	protein	NNS
cord-306904-8iteddug	33	35	containing	contain	VBG
cord-306904-8iteddug	33	36	both	both	CC
cord-306904-8iteddug	33	37	ordered	order	VBN
cord-306904-8iteddug	33	38	and	and	CC
cord-306904-8iteddug	33	39	disordered	disordered	JJ
cord-306904-8iteddug	33	40	regions	region	NNS
cord-306904-8iteddug	33	41	)	)	-RRB-
cord-306904-8iteddug	33	42	not	not	RB
cord-306904-8iteddug	33	43	recognizing	recognize	VBG
cord-306904-8iteddug	33	44	that	that	IN
cord-306904-8iteddug	33	45	they	-PRON-	PRP
cord-306904-8iteddug	33	46	are	be	VBP
cord-306904-8iteddug	33	47	talking	talk	VBG
cord-306904-8iteddug	33	48	about	about	IN
cord-306904-8iteddug	33	49	such	such	JJ
cord-306904-8iteddug	33	50	proteins	protein	NNS
cord-306904-8iteddug	33	51	,	,	,
cord-306904-8iteddug	33	52	to	to	TO
cord-306904-8iteddug	33	53	show	show	VB
cord-306904-8iteddug	33	54	how	how	WRB
cord-306904-8iteddug	33	55	consideration	consideration	NN
cord-306904-8iteddug	33	56	of	of	IN
cord-306904-8iteddug	33	57	intrinsic	intrinsic	JJ
cord-306904-8iteddug	33	58	disorder	disorder	NN
cord-306904-8iteddug	33	59	can	can	MD
cord-306904-8iteddug	33	60	be	be	VB
cord-306904-8iteddug	33	61	used	use	VBN
cord-306904-8iteddug	33	62	to	to	TO
cord-306904-8iteddug	33	63	strengthen	strengthen	VB
cord-306904-8iteddug	33	64	conclusions	conclusion	NNS
cord-306904-8iteddug	33	65	and	and	CC
cord-306904-8iteddug	33	66	draw	draw	VB
cord-306904-8iteddug	33	67	relationships	relationship	NNS
cord-306904-8iteddug	33	68	to	to	IN
cord-306904-8iteddug	33	69	prior	prior	JJ
cord-306904-8iteddug	33	70	discoveries	discovery	NNS
cord-306904-8iteddug	33	71	in	in	IN
cord-306904-8iteddug	33	72	the	the	DT
cord-306904-8iteddug	33	73	field	field	NN
cord-306904-8iteddug	33	74	.	.	.
cord-306904-8iteddug	34	1	However	however	RB
cord-306904-8iteddug	34	2	,	,	,
cord-306904-8iteddug	34	3	analysis	analysis	NN
cord-306904-8iteddug	34	4	of	of	IN
cord-306904-8iteddug	34	5	recent	recent	JJ
cord-306904-8iteddug	34	6	publications	publication	NNS
cord-306904-8iteddug	34	7	in	in	IN
cord-306904-8iteddug	34	8	just	just	RB
cord-306904-8iteddug	34	9	2	2	CD
cord-306904-8iteddug	34	10	journals	journal	NNS
cord-306904-8iteddug	34	11	revealed	reveal	VBD
cord-306904-8iteddug	34	12	that	that	IN
cord-306904-8iteddug	34	13	the	the	DT
cord-306904-8iteddug	34	14	"	"	``
cord-306904-8iteddug	34	15	missed	missed	JJ
cord-306904-8iteddug	34	16	disorder	disorder	NN
cord-306904-8iteddug	34	17	"	"	''
cord-306904-8iteddug	34	18	happened	happen	VBD
cord-306904-8iteddug	34	19	to	to	TO
cord-306904-8iteddug	34	20	be	be	VB
cord-306904-8iteddug	34	21	essentially	essentially	RB
cord-306904-8iteddug	34	22	more	more	RBR
cord-306904-8iteddug	34	23	abundant	abundant	JJ
cord-306904-8iteddug	34	24	than	than	IN
cord-306904-8iteddug	34	25	it	-PRON-	PRP
cord-306904-8iteddug	34	26	was	be	VBD
cord-306904-8iteddug	34	27	originally	originally	RB
cord-306904-8iteddug	34	28	expected	expect	VBN
cord-306904-8iteddug	34	29	.	.	.
cord-306904-8iteddug	35	1	In	in	IN
cord-306904-8iteddug	35	2	fact	fact	NN
cord-306904-8iteddug	35	3	,	,	,
cord-306904-8iteddug	35	4	as	as	IN
cord-306904-8iteddug	35	5	of	of	IN
cord-306904-8iteddug	35	6	August	August	NNP
cord-306904-8iteddug	35	7	3	3	CD
cord-306904-8iteddug	35	8	,	,	,
cord-306904-8iteddug	35	9	2014	2014	CD
cord-306904-8iteddug	35	10	,	,	,
cord-306904-8iteddug	35	11	of	of	IN
cord-306904-8iteddug	35	12	677	677	CD
cord-306904-8iteddug	35	13	papers	paper	NNS
cord-306904-8iteddug	35	14	published	publish	VBN
cord-306904-8iteddug	35	15	during	during	IN
cord-306904-8iteddug	35	16	2013	2013	CD
cord-306904-8iteddug	35	17	-	-	SYM
cord-306904-8iteddug	35	18	2014	2014	CD
cord-306904-8iteddug	35	19	in	in	IN
cord-306904-8iteddug	35	20	the	the	DT
cord-306904-8iteddug	35	21	Journal	Journal	NNP
cord-306904-8iteddug	35	22	of	of	IN
cord-306904-8iteddug	35	23	Molecular	Molecular	NNP
cord-306904-8iteddug	35	24	Biology	Biology	NNP
cord-306904-8iteddug	35	25	,	,	,
cord-306904-8iteddug	35	26	609	609	CD
cord-306904-8iteddug	35	27	were	be	VBD
cord-306904-8iteddug	35	28	dealing	deal	VBG
cord-306904-8iteddug	35	29	with	with	IN
cord-306904-8iteddug	35	30	proteins	protein	NNS
cord-306904-8iteddug	35	31	,	,	,
cord-306904-8iteddug	35	32	with	with	IN
cord-306904-8iteddug	35	33	87	87	CD
cord-306904-8iteddug	35	34	papers	paper	NNS
cord-306904-8iteddug	35	35	being	be	VBG
cord-306904-8iteddug	35	36	dedicated	dedicate	VBN
cord-306904-8iteddug	35	37	to	to	IN
cord-306904-8iteddug	35	38	the	the	DT
cord-306904-8iteddug	35	39	IDPs	idps	JJ
cord-306904-8iteddug	35	40	or	or	CC
cord-306904-8iteddug	35	41	hybrid	hybrid	JJ
cord-306904-8iteddug	35	42	proteins	protein	NNS
cord-306904-8iteddug	35	43	.	.	.
cord-306904-8iteddug	36	1	Papers	paper	NNS
cord-306904-8iteddug	36	2	were	be	VBD
cord-306904-8iteddug	36	3	considered	consider	VBN
cord-306904-8iteddug	36	4	to	to	TO
cord-306904-8iteddug	36	5	be	be	VB
cord-306904-8iteddug	36	6	dealing	deal	VBG
cord-306904-8iteddug	36	7	with	with	IN
cord-306904-8iteddug	36	8	intrinsic	intrinsic	JJ
cord-306904-8iteddug	36	9	disorder	disorder	NN
cord-306904-8iteddug	36	10	if	if	IN
cord-306904-8iteddug	36	11	their	-PRON-	PRP$
cord-306904-8iteddug	36	12	texts	text	NNS
cord-306904-8iteddug	36	13	contained	contain	VBN
cord-306904-8iteddug	36	14	at	at	IN
cord-306904-8iteddug	36	15	least	least	JJS
cord-306904-8iteddug	36	16	a	a	DT
cord-306904-8iteddug	36	17	single	single	JJ
cord-306904-8iteddug	36	18	mention	mention	NN
cord-306904-8iteddug	36	19	of	of	IN
cord-306904-8iteddug	36	20	disorder	disorder	NN
cord-306904-8iteddug	36	21	,	,	,
cord-306904-8iteddug	36	22	flexibility	flexibility	NN
cord-306904-8iteddug	36	23	,	,	,
cord-306904-8iteddug	36	24	conformational	conformational	JJ
cord-306904-8iteddug	36	25	flexibility	flexibility	NN
cord-306904-8iteddug	36	26	,	,	,
cord-306904-8iteddug	36	27	or	or	CC
cord-306904-8iteddug	36	28	unfoldedness	unfoldedness	NN
cord-306904-8iteddug	36	29	in	in	IN
cord-306904-8iteddug	36	30	relation	relation	NN
cord-306904-8iteddug	36	31	to	to	IN
cord-306904-8iteddug	36	32	the	the	DT
cord-306904-8iteddug	36	33	protein	protein	NN
cord-306904-8iteddug	36	34	of	of	IN
cord-306904-8iteddug	36	35	interest	interest	NN
cord-306904-8iteddug	36	36	or	or	CC
cord-306904-8iteddug	36	37	any	any	DT
cord-306904-8iteddug	36	38	of	of	IN
cord-306904-8iteddug	36	39	its	-PRON-	PRP$
cord-306904-8iteddug	36	40	regions	region	NNS
cord-306904-8iteddug	36	41	.	.	.
cord-306904-8iteddug	37	1	Obviously	obviously	RB
cord-306904-8iteddug	37	2	,	,	,
cord-306904-8iteddug	37	3	this	this	DT
cord-306904-8iteddug	37	4	is	be	VBZ
cord-306904-8iteddug	37	5	a	a	DT
cord-306904-8iteddug	37	6	very	very	RB
cord-306904-8iteddug	37	7	relaxed	relaxed	JJ
cord-306904-8iteddug	37	8	and	and	CC
cord-306904-8iteddug	37	9	inclusive	inclusive	JJ
cord-306904-8iteddug	37	10	approach	approach	NN
cord-306904-8iteddug	37	11	,	,	,
cord-306904-8iteddug	37	12	since	since	IN
cord-306904-8iteddug	37	13	simple	simple	JJ
cord-306904-8iteddug	37	14	mentioning	mentioning	NN
cord-306904-8iteddug	37	15	of	of	IN
cord-306904-8iteddug	37	16	disorder	disorder	NN
cord-306904-8iteddug	37	17	or	or	CC
cord-306904-8iteddug	37	18	conformational	conformational	JJ
cord-306904-8iteddug	37	19	flexibility	flexibility	NN
cord-306904-8iteddug	37	20	is	be	VBZ
cord-306904-8iteddug	37	21	not	not	RB
cord-306904-8iteddug	37	22	sufficient	sufficient	JJ
cord-306904-8iteddug	37	23	for	for	IN
cord-306904-8iteddug	37	24	the	the	DT
cord-306904-8iteddug	37	25	detailed	detailed	JJ
cord-306904-8iteddug	37	26	elucidation	elucidation	NN
cord-306904-8iteddug	37	27	of	of	IN
cord-306904-8iteddug	37	28	the	the	DT
cord-306904-8iteddug	37	29	functional	functional	JJ
cord-306904-8iteddug	37	30	role	role	NN
cord-306904-8iteddug	37	31	of	of	IN
cord-306904-8iteddug	37	32	disorder	disorder	NN
cord-306904-8iteddug	37	33	/	/	SYM
cord-306904-8iteddug	37	34	flexibility	flexibility	NN
cord-306904-8iteddug	37	35	.	.	.
cord-306904-8iteddug	38	1	The	the	DT
cord-306904-8iteddug	38	2	direct	direct	JJ
cord-306904-8iteddug	38	3	PubMed	PubMed	NNP
cord-306904-8iteddug	38	4	search	search	NN
cord-306904-8iteddug	38	5	for	for	IN
cord-306904-8iteddug	38	6	the	the	DT
cord-306904-8iteddug	38	7	IDPrelated	idprelated	JJ
cord-306904-8iteddug	38	8	papers	paper	NNS
cord-306904-8iteddug	38	9	published	publish	VBN
cord-306904-8iteddug	38	10	in	in	IN
cord-306904-8iteddug	38	11	the	the	DT
cord-306904-8iteddug	38	12	Journal	Journal	NNP
cord-306904-8iteddug	38	13	of	of	IN
cord-306904-8iteddug	38	14	Molecular	Molecular	NNP
cord-306904-8iteddug	38	15	Biology	Biology	NNP
cord-306904-8iteddug	38	16	using	use	VBG
cord-306904-8iteddug	38	17	the	the	DT
cord-306904-8iteddug	38	18	search	search	NN
cord-306904-8iteddug	38	19	criteria	criterion	NNS
cord-306904-8iteddug	38	20	(	(	-LRB-
cord-306904-8iteddug	38	21	(	(	-LRB-
cord-306904-8iteddug	38	22	intrinsic	intrinsic	JJ
cord-306904-8iteddug	38	23	disorder	disorder	NN
cord-306904-8iteddug	38	24	)	)	-RRB-
cord-306904-8iteddug	38	25	OR	or	CC
cord-306904-8iteddug	38	26	(	(	-LRB-
cord-306904-8iteddug	38	27	intrinsically	intrinsically	RB
cord-306904-8iteddug	38	28	disordered	disordered	JJ
cord-306904-8iteddug	38	29	)	)	-RRB-
cord-306904-8iteddug	38	30	OR	or	CC
cord-306904-8iteddug	38	31	(	(	-LRB-
cord-306904-8iteddug	38	32	natively	natively	RB
cord-306904-8iteddug	38	33	unfolded	unfold	VBN
cord-306904-8iteddug	38	34	)	)	-RRB-
cord-306904-8iteddug	38	35	OR	or	CC
cord-306904-8iteddug	38	36	(	(	-LRB-
cord-306904-8iteddug	38	37	intrinsically	intrinsically	RB
cord-306904-8iteddug	38	38	unstructured	unstructured	JJ
cord-306904-8iteddug	38	39	)	)	-RRB-
cord-306904-8iteddug	38	40	OR	or	CC
cord-306904-8iteddug	38	41	(	(	-LRB-
cord-306904-8iteddug	38	42	intrinsically	intrinsically	RB
cord-306904-8iteddug	38	43	unfolded	unfold	VBN
cord-306904-8iteddug	38	44	)	)	-RRB-
cord-306904-8iteddug	38	45	OR	or	CC
cord-306904-8iteddug	38	46	(	(	-LRB-
cord-306904-8iteddug	38	47	intrinsically	intrinsically	RB
cord-306904-8iteddug	38	48	flexible	flexible	JJ
cord-306904-8iteddug	38	49	protein	protein	NN
cord-306904-8iteddug	38	50	)	)	-RRB-
cord-306904-8iteddug	38	51	)	)	-RRB-
cord-306904-8iteddug	39	1	AND	and	CC
cord-306904-8iteddug	39	2	(	(	-LRB-
cord-306904-8iteddug	39	3	"	"	``
cord-306904-8iteddug	39	4	2013/01/01	2013/01/01	CD
cord-306904-8iteddug	39	5	"	"	''
cord-306904-8iteddug	39	6	[	[	-LRB-
cord-306904-8iteddug	39	7	Date	date	NN
cord-306904-8iteddug	39	8	-Publication	-publication	NN
cord-306904-8iteddug	39	9	]	]	-RRB-
cord-306904-8iteddug	39	10	:	:	:
cord-306904-8iteddug	39	11	"	"	``
cord-306904-8iteddug	39	12	3000"[Date	3000"[date	CD
cord-306904-8iteddug	39	13	-Publication	-publication	NN
cord-306904-8iteddug	39	14	]	]	-RRB-
cord-306904-8iteddug	39	15	)	)	-RRB-
cord-306904-8iteddug	40	1	AND	and	CC
cord-306904-8iteddug	40	2	(	(	-LRB-
cord-306904-8iteddug	40	3	"	"	``
cord-306904-8iteddug	40	4	Journal	Journal	NNP
cord-306904-8iteddug	40	5	of	of	IN
cord-306904-8iteddug	41	1	Molecular	Molecular	NNP
cord-306904-8iteddug	41	2	Biology"[Journal	Biology"[Journal	NNP
cord-306904-8iteddug	41	3	]	]	-RRB-
cord-306904-8iteddug	41	4	)	)	-RRB-
cord-306904-8iteddug	41	5	generated	generate	VBD
cord-306904-8iteddug	41	6	just	just	RB
cord-306904-8iteddug	41	7	17	17	CD
cord-306904-8iteddug	41	8	hits	hit	NNS
cord-306904-8iteddug	41	9	.	.	.
cord-306904-8iteddug	42	1	Analysis	analysis	NN
cord-306904-8iteddug	42	2	of	of	IN
cord-306904-8iteddug	42	3	the	the	DT
cord-306904-8iteddug	42	4	table	table	NN
cord-306904-8iteddug	42	5	of	of	IN
cord-306904-8iteddug	42	6	content	content	NN
cord-306904-8iteddug	42	7	of	of	IN
cord-306904-8iteddug	42	8	this	this	DT
cord-306904-8iteddug	42	9	journal	journal	NN
cord-306904-8iteddug	42	10	combined	combine	VBN
cord-306904-8iteddug	42	11	with	with	IN
cord-306904-8iteddug	42	12	a	a	DT
cord-306904-8iteddug	42	13	brief	brief	JJ
cord-306904-8iteddug	42	14	computational	computational	JJ
cord-306904-8iteddug	42	15	analysis	analysis	NN
cord-306904-8iteddug	42	16	of	of	IN
cord-306904-8iteddug	42	17	related	related	JJ
cord-306904-8iteddug	42	18	proteins	protein	NNS
cord-306904-8iteddug	42	19	revealed	reveal	VBD
cord-306904-8iteddug	42	20	that	that	IN
cord-306904-8iteddug	42	21	there	there	EX
cord-306904-8iteddug	42	22	are	be	VBP
cord-306904-8iteddug	42	23	at	at	IN
cord-306904-8iteddug	42	24	least	least	JJS
cord-306904-8iteddug	42	25	22	22	CD
cord-306904-8iteddug	42	26	more	more	JJR
cord-306904-8iteddug	42	27	papers	paper	NNS
cord-306904-8iteddug	42	28	,	,	,
cord-306904-8iteddug	42	29	research	research	NN
cord-306904-8iteddug	42	30	subject	subject	NN
cord-306904-8iteddug	42	31	of	of	IN
cord-306904-8iteddug	42	32	which	which	WDT
cord-306904-8iteddug	42	33	are	be	VBP
cord-306904-8iteddug	42	34	IDPs	idps	JJ
cord-306904-8iteddug	42	35	.	.	.
cord-306904-8iteddug	43	1	Analogous	analogous	JJ
cord-306904-8iteddug	43	2	analysis	analysis	NN
cord-306904-8iteddug	43	3	of	of	IN
cord-306904-8iteddug	43	4	the	the	DT
cord-306904-8iteddug	43	5	publications	publication	NNS
cord-306904-8iteddug	43	6	in	in	IN
cord-306904-8iteddug	43	7	Biochemistry	Biochemistry	NNP
cord-306904-8iteddug	43	8	during	during	IN
cord-306904-8iteddug	43	9	the	the	DT
cord-306904-8iteddug	43	10	2013	2013	CD
cord-306904-8iteddug	43	11	-	-	SYM
cord-306904-8iteddug	43	12	2014	2014	CD
cord-306904-8iteddug	43	13	provided	provide	VBN
cord-306904-8iteddug	43	14	comparable	comparable	JJ
cord-306904-8iteddug	43	15	data	datum	NNS
cord-306904-8iteddug	43	16	:	:	:
cord-306904-8iteddug	43	17	of	of	IN
cord-306904-8iteddug	43	18	1455	1455	CD
cord-306904-8iteddug	43	19	published	publish	VBN
cord-306904-8iteddug	43	20	papers	paper	NNS
cord-306904-8iteddug	43	21	,	,	,
cord-306904-8iteddug	43	22	25	25	CD
cord-306904-8iteddug	43	23	were	be	VBD
cord-306904-8iteddug	43	24	"	"	``
cord-306904-8iteddug	43	25	officially	officially	RB
cord-306904-8iteddug	43	26	"	"	''
cord-306904-8iteddug	43	27	dedicated	dedicated	JJ
cord-306904-8iteddug	43	28	to	to	IN
cord-306904-8iteddug	43	29	intrinsic	intrinsic	JJ
cord-306904-8iteddug	43	30	disorder	disorder	NN
cord-306904-8iteddug	43	31	or	or	CC
cord-306904-8iteddug	43	32	to	to	IN
cord-306904-8iteddug	43	33	intrinsically	intrinsically	RB
cord-306904-8iteddug	43	34	disordered	disordered	JJ
cord-306904-8iteddug	43	35	/	/	,
cord-306904-8iteddug	43	36	natively	natively	RB
cord-306904-8iteddug	43	37	unfolded	unfold	VBN
cord-306904-8iteddug	43	38	/	/	,
cord-306904-8iteddug	43	39	intrinsically	intrinsically	RB
cord-306904-8iteddug	43	40	unstructured/	unstructured/	VBG
cord-306904-8iteddug	43	41	intrinsically	intrinsically	RB
cord-306904-8iteddug	43	42	unfolded	unfold	VBD
cord-306904-8iteddug	43	43	/	/	,
cord-306904-8iteddug	43	44	intrinsically	intrinsically	RB
cord-306904-8iteddug	43	45	flexible	flexible	JJ
cord-306904-8iteddug	43	46	proteins	protein	NNS
cord-306904-8iteddug	43	47	.	.	.
cord-306904-8iteddug	44	1	Mining	mining	NN
cord-306904-8iteddug	44	2	of	of	IN
cord-306904-8iteddug	44	3	papers	paper	NNS
cord-306904-8iteddug	44	4	published	publish	VBN
cord-306904-8iteddug	44	5	in	in	IN
cord-306904-8iteddug	44	6	Biochemistry	Biochemistry	NNP
cord-306904-8iteddug	44	7	during	during	IN
cord-306904-8iteddug	44	8	2013	2013	CD
cord-306904-8iteddug	44	9	-	-	SYM
cord-306904-8iteddug	44	10	2014	2014	CD
cord-306904-8iteddug	44	11	revealed	reveal	VBD
cord-306904-8iteddug	44	12	that	that	IN
cord-306904-8iteddug	44	13	some	some	DT
cord-306904-8iteddug	44	14	189	189	CD
cord-306904-8iteddug	44	15	papers	paper	NNS
cord-306904-8iteddug	44	16	contained	contain	VBN
cord-306904-8iteddug	44	17	at	at	IN
cord-306904-8iteddug	44	18	least	least	JJS
cord-306904-8iteddug	44	19	a	a	DT
cord-306904-8iteddug	44	20	single	single	JJ
cord-306904-8iteddug	44	21	mention	mention	NN
cord-306904-8iteddug	44	22	of	of	IN
cord-306904-8iteddug	44	23	"	"	``
cord-306904-8iteddug	44	24	conformational	conformational	JJ
cord-306904-8iteddug	44	25	flexibility	flexibility	NN
cord-306904-8iteddug	44	26	"	"	''
cord-306904-8iteddug	44	27	OR	or	CC
cord-306904-8iteddug	44	28	"	"	''
cord-306904-8iteddug	44	29	intrinsic	intrinsic	JJ
cord-306904-8iteddug	44	30	disorder	disorder	NN
cord-306904-8iteddug	44	31	"	"	''
cord-306904-8iteddug	44	32	OR	or	CC
cord-306904-8iteddug	44	33	"	"	``
cord-306904-8iteddug	44	34	disordered	disordered	JJ
cord-306904-8iteddug	44	35	protein	protein	NN
cord-306904-8iteddug	44	36	"	"	''
cord-306904-8iteddug	44	37	OR	or	CC
cord-306904-8iteddug	44	38	"	"	``
cord-306904-8iteddug	44	39	disordered	disordered	JJ
cord-306904-8iteddug	44	40	peptide	peptide	NN
cord-306904-8iteddug	44	41	"	"	''
cord-306904-8iteddug	44	42	OR	or	CC
cord-306904-8iteddug	44	43	"	"	``
cord-306904-8iteddug	44	44	disordered	disordered	JJ
cord-306904-8iteddug	44	45	region	region	NN
cord-306904-8iteddug	44	46	"	"	''
cord-306904-8iteddug	44	47	OR	or	CC
cord-306904-8iteddug	44	48	"	"	''
cord-306904-8iteddug	44	49	natively	natively	RB
cord-306904-8iteddug	44	50	unfolded	unfold	VBN
cord-306904-8iteddug	44	51	"	"	''
cord-306904-8iteddug	44	52	in	in	IN
cord-306904-8iteddug	44	53	relation	relation	NN
cord-306904-8iteddug	44	54	to	to	IN
cord-306904-8iteddug	44	55	the	the	DT
cord-306904-8iteddug	44	56	protein	protein	NN
cord-306904-8iteddug	44	57	of	of	IN
cord-306904-8iteddug	44	58	interest	interest	NN
cord-306904-8iteddug	44	59	or	or	CC
cord-306904-8iteddug	44	60	any	any	DT
cord-306904-8iteddug	44	61	of	of	IN
cord-306904-8iteddug	44	62	its	-PRON-	PRP$
cord-306904-8iteddug	44	63	regions	region	NNS
cord-306904-8iteddug	44	64	.	.	.
cord-306904-8iteddug	45	1	Furthermore	furthermore	RB
cord-306904-8iteddug	45	2	,	,	,
cord-306904-8iteddug	45	3	based	base	VBN
cord-306904-8iteddug	45	4	on	on	IN
cord-306904-8iteddug	45	5	the	the	DT
cord-306904-8iteddug	45	6	combination	combination	NN
cord-306904-8iteddug	45	7	of	of	IN
cord-306904-8iteddug	45	8	literature	literature	NN
cord-306904-8iteddug	45	9	mining	mining	NN
cord-306904-8iteddug	45	10	and	and	CC
cord-306904-8iteddug	45	11	a	a	DT
cord-306904-8iteddug	45	12	brief	brief	JJ
cord-306904-8iteddug	45	13	computational	computational	JJ
cord-306904-8iteddug	45	14	analysis	analysis	NN
cord-306904-8iteddug	45	15	20	20	CD
cord-306904-8iteddug	45	16	"	"	``
cord-306904-8iteddug	45	17	hidden	hide	VBN
cord-306904-8iteddug	45	18	gems	gem	NNS
cord-306904-8iteddug	45	19	"	"	''
cord-306904-8iteddug	45	20	were	be	VBD
cord-306904-8iteddug	45	21	found	find	VBN
cord-306904-8iteddug	45	22	;	;	:
cord-306904-8iteddug	45	23	i.e.	i.e.	FW
cord-306904-8iteddug	45	24	,	,	,
cord-306904-8iteddug	45	25	papers	paper	NNS
cord-306904-8iteddug	45	26	that	that	WDT
cord-306904-8iteddug	45	27	missed	miss	VBD
cord-306904-8iteddug	45	28	protein	protein	NN
cord-306904-8iteddug	45	29	disorder	disorder	NN
cord-306904-8iteddug	45	30	.	.	.
cord-306904-8iteddug	46	1	The	the	DT
cord-306904-8iteddug	46	2	mentioned	mention	VBN
cord-306904-8iteddug	46	3	42	42	CD
cord-306904-8iteddug	46	4	papers	paper	NNS
cord-306904-8iteddug	46	5	dealing	deal	VBG
cord-306904-8iteddug	46	6	with	with	IN
cord-306904-8iteddug	46	7	the	the	DT
cord-306904-8iteddug	46	8	unreported	unreported	JJ
cord-306904-8iteddug	46	9	intrinsic	intrinsic	JJ
cord-306904-8iteddug	46	10	disorder	disorder	NN
cord-306904-8iteddug	46	11	and	and	CC
cord-306904-8iteddug	46	12	their	-PRON-	PRP$
cord-306904-8iteddug	46	13	related	relate	VBN
cord-306904-8iteddug	46	14	IDPs	idp	NNS
cord-306904-8iteddug	46	15	or	or	CC
cord-306904-8iteddug	46	16	hybrid	hybrid	JJ
cord-306904-8iteddug	46	17	proteins	protein	NNS
cord-306904-8iteddug	46	18	containing	contain	VBG
cord-306904-8iteddug	46	19	ordered	order	VBN
cord-306904-8iteddug	46	20	and	and	CC
cord-306904-8iteddug	46	21	intrinsically	intrinsically	RB
cord-306904-8iteddug	46	22	disordered	disordered	JJ
cord-306904-8iteddug	46	23	regions	region	NNS
cord-306904-8iteddug	46	24	are	be	VBP
cord-306904-8iteddug	46	25	briefly	briefly	RB
cord-306904-8iteddug	46	26	outlined	outline	VBN
cord-306904-8iteddug	46	27	below	below	RB
cord-306904-8iteddug	46	28	.	.	.
cord-306904-8iteddug	47	1	Table	table	NN
cord-306904-8iteddug	47	2	1	1	CD
cord-306904-8iteddug	47	3	contains	contain	VBZ
cord-306904-8iteddug	47	4	all	all	PDT
cord-306904-8iteddug	47	5	the	the	DT
cord-306904-8iteddug	47	6	proteins	protein	NNS
cord-306904-8iteddug	47	7	considered	consider	VBN
cord-306904-8iteddug	47	8	in	in	IN
cord-306904-8iteddug	47	9	this	this	DT
cord-306904-8iteddug	47	10	review	review	NN
cord-306904-8iteddug	47	11	.	.	.
cord-306904-8iteddug	48	1	Proteins	protein	NNS
cord-306904-8iteddug	48	2	are	be	VBP
cord-306904-8iteddug	48	3	arranged	arrange	VBN
cord-306904-8iteddug	48	4	according	accord	VBG
cord-306904-8iteddug	48	5	to	to	IN
cord-306904-8iteddug	48	6	the	the	DT
cord-306904-8iteddug	48	7	increase	increase	NN
cord-306904-8iteddug	48	8	in	in	IN
cord-306904-8iteddug	48	9	the	the	DT
cord-306904-8iteddug	48	10	extent	extent	NN
cord-306904-8iteddug	48	11	of	of	IN
cord-306904-8iteddug	48	12	their	-PRON-	PRP$
cord-306904-8iteddug	48	13	disorder	disorder	NN
cord-306904-8iteddug	48	14	evaluated	evaluate	VBN
cord-306904-8iteddug	48	15	as	as	IN
cord-306904-8iteddug	48	16	percentage	percentage	NN
cord-306904-8iteddug	48	17	of	of	IN
cord-306904-8iteddug	48	18	the	the	DT
cord-306904-8iteddug	48	19	residues	residue	NNS
cord-306904-8iteddug	48	20	predicted	predict	VBN
cord-306904-8iteddug	48	21	to	to	TO
cord-306904-8iteddug	48	22	be	be	VB
cord-306904-8iteddug	48	23	disordered	disordered	JJ
cord-306904-8iteddug	48	24	(	(	-LRB-
cord-306904-8iteddug	48	25	i.e.	i.e.	FW
cord-306904-8iteddug	48	26	,	,	,
cord-306904-8iteddug	48	27	possessing	possess	VBG
cord-306904-8iteddug	48	28	disorder	disorder	NN
cord-306904-8iteddug	48	29	scores	score	NNS
cord-306904-8iteddug	48	30	above	above	IN
cord-306904-8iteddug	48	31	0.5	0.5	CD
cord-306904-8iteddug	48	32	)	)	-RRB-
cord-306904-8iteddug	48	33	by	by	IN
cord-306904-8iteddug	48	34	PONDR	PONDR	NNP
cord-306904-8iteddug	48	35	Ò	Ò	NNP
cord-306904-8iteddug	48	36	VSL2	VSL2	NNP
cord-306904-8iteddug	48	37	,	,	,
cord-306904-8iteddug	48	38	which	which	WDT
cord-306904-8iteddug	48	39	is	be	VBZ
cord-306904-8iteddug	48	40	among	among	IN
cord-306904-8iteddug	48	41	the	the	DT
cord-306904-8iteddug	48	42	more	more	RBR
cord-306904-8iteddug	48	43	accurate	accurate	JJ
cord-306904-8iteddug	48	44	disorder	disorder	NN
cord-306904-8iteddug	48	45	predictors	predictor	NNS
cord-306904-8iteddug	48	46	.	.	.
cord-306904-8iteddug	49	1	4	4	LS
cord-306904-8iteddug	49	2	Table	table	NN
cord-306904-8iteddug	49	3	1	1	CD
cord-306904-8iteddug	49	4	shows	show	VBZ
cord-306904-8iteddug	49	5	that	that	IN
cord-306904-8iteddug	49	6	the	the	DT
cord-306904-8iteddug	49	7	extent	extent	NN
cord-306904-8iteddug	49	8	of	of	IN
cord-306904-8iteddug	49	9	unreported	unreported	JJ
cord-306904-8iteddug	49	10	intrinsic	intrinsic	JJ
cord-306904-8iteddug	49	11	disorder	disorder	NN
cord-306904-8iteddug	49	12	in	in	IN
cord-306904-8iteddug	49	13	143	143	CD
cord-306904-8iteddug	49	14	proteins	protein	NNS
cord-306904-8iteddug	49	15	ranges	range	VBZ
cord-306904-8iteddug	49	16	from	from	IN
cord-306904-8iteddug	49	17	10	10	CD
cord-306904-8iteddug	49	18	%	%	NN
cord-306904-8iteddug	49	19	to	to	IN
cord-306904-8iteddug	49	20	100	100	CD
cord-306904-8iteddug	49	21	%	%	NN
cord-306904-8iteddug	49	22	,	,	,
cord-306904-8iteddug	49	23	indicating	indicate	VBG
cord-306904-8iteddug	49	24	that	that	IN
cord-306904-8iteddug	49	25	all	all	PDT
cord-306904-8iteddug	49	26	these	these	DT
cord-306904-8iteddug	49	27	proteins	protein	NNS
cord-306904-8iteddug	49	28	belong	belong	VBP
cord-306904-8iteddug	49	29	to	to	IN
cord-306904-8iteddug	49	30	the	the	DT
cord-306904-8iteddug	49	31	category	category	NN
cord-306904-8iteddug	49	32	of	of	IN
cord-306904-8iteddug	49	33	moderately	moderately	RB
cord-306904-8iteddug	49	34	or	or	CC
cord-306904-8iteddug	49	35	highly	highly	RB
cord-306904-8iteddug	49	36	disordered	disordered	JJ
cord-306904-8iteddug	49	37	proteins	protein	NNS
cord-306904-8iteddug	49	38	;	;	:
cord-306904-8iteddug	49	39	i.e.	i.e.	FW
cord-306904-8iteddug	49	40	,	,	,
cord-306904-8iteddug	49	41	proteins	protein	NNS
cord-306904-8iteddug	49	42	with	with	IN
cord-306904-8iteddug	49	43	the	the	DT
cord-306904-8iteddug	49	44	disorder	disorder	NN
cord-306904-8iteddug	49	45	content	content	NN
cord-306904-8iteddug	49	46	ranging	range	VBG
cord-306904-8iteddug	49	47	from	from	IN
cord-306904-8iteddug	49	48	10	10	CD
cord-306904-8iteddug	49	49	%	%	NN
cord-306904-8iteddug	49	50	to	to	TO
cord-306904-8iteddug	49	51	30	30	CD
cord-306904-8iteddug	49	52	%	%	NN
cord-306904-8iteddug	49	53	and	and	CC
cord-306904-8iteddug	49	54	from	from	IN
cord-306904-8iteddug	49	55	30	30	CD
cord-306904-8iteddug	49	56	%	%	NN
cord-306904-8iteddug	49	57	to	to	TO
cord-306904-8iteddug	49	58	100	100	CD
cord-306904-8iteddug	49	59	%	%	NN
cord-306904-8iteddug	49	60	,	,	,
cord-306904-8iteddug	49	61	respectively	respectively	RB
cord-306904-8iteddug	49	62	.	.	.
cord-306904-8iteddug	50	1	Table	table	NN
cord-306904-8iteddug	50	2	1	1	CD
cord-306904-8iteddug	50	3	also	also	RB
cord-306904-8iteddug	50	4	shows	show	VBZ
cord-306904-8iteddug	50	5	that	that	IN
cord-306904-8iteddug	50	6	a	a	DT
cord-306904-8iteddug	50	7	very	very	RB
cord-306904-8iteddug	50	8	significant	significant	JJ
cord-306904-8iteddug	50	9	fraction	fraction	NN
cord-306904-8iteddug	50	10	of	of	IN
cord-306904-8iteddug	50	11	such	such	JJ
cord-306904-8iteddug	50	12	proteins	protein	NNS
cord-306904-8iteddug	50	13	with	with	IN
cord-306904-8iteddug	50	14	overlooked	overlooked	JJ
cord-306904-8iteddug	50	15	disorder	disorder	NN
cord-306904-8iteddug	50	16	(	(	-LRB-
cord-306904-8iteddug	50	17	>	>	NFP
cord-306904-8iteddug	50	18	75	75	CD
cord-306904-8iteddug	50	19	%	%	NN
cord-306904-8iteddug	50	20	)	)	-RRB-
cord-306904-8iteddug	50	21	belongs	belong	VBZ
cord-306904-8iteddug	50	22	to	to	IN
cord-306904-8iteddug	50	23	the	the	DT
cord-306904-8iteddug	50	24	"	"	``
cord-306904-8iteddug	50	25	highly	highly	RB
cord-306904-8iteddug	50	26	disordered	disordered	JJ
cord-306904-8iteddug	50	27	"	"	''
cord-306904-8iteddug	50	28	category	category	NN
cord-306904-8iteddug	50	29	.	.	.
cord-306904-8iteddug	51	1	The	the	DT
cord-306904-8iteddug	51	2	order	order	NN
cord-306904-8iteddug	51	3	of	of	IN
cord-306904-8iteddug	51	4	sections	section	NNS
cord-306904-8iteddug	51	5	in	in	IN
cord-306904-8iteddug	51	6	this	this	DT
cord-306904-8iteddug	51	7	review	review	NN
cord-306904-8iteddug	51	8	crudely	crudely	RB
cord-306904-8iteddug	51	9	follows	follow	VBZ
cord-306904-8iteddug	51	10	the	the	DT
cord-306904-8iteddug	51	11	order	order	NN
cord-306904-8iteddug	51	12	of	of	IN
cord-306904-8iteddug	51	13	proteins	protein	NNS
cord-306904-8iteddug	51	14	in	in	IN
cord-306904-8iteddug	51	15	Table	Table	NNP
cord-306904-8iteddug	51	16	1	1	CD
cord-306904-8iteddug	51	17	.	.	.
cord-306904-8iteddug	52	1	When	when	WRB
cord-306904-8iteddug	52	2	several	several	JJ
cord-306904-8iteddug	52	3	proteins	protein	NNS
cord-306904-8iteddug	52	4	are	be	VBP
cord-306904-8iteddug	52	5	discussed	discuss	VBN
cord-306904-8iteddug	52	6	in	in	IN
cord-306904-8iteddug	52	7	a	a	DT
cord-306904-8iteddug	52	8	paper	paper	NN
cord-306904-8iteddug	52	9	,	,	,
cord-306904-8iteddug	52	10	the	the	DT
cord-306904-8iteddug	52	11	corresponding	corresponding	JJ
cord-306904-8iteddug	52	12	section	section	NN
cord-306904-8iteddug	52	13	within	within	IN
cord-306904-8iteddug	52	14	the	the	DT
cord-306904-8iteddug	52	15	text	text	NN
cord-306904-8iteddug	52	16	is	be	VBZ
cord-306904-8iteddug	52	17	placed	place	VBN
cord-306904-8iteddug	52	18	at	at	IN
cord-306904-8iteddug	52	19	a	a	DT
cord-306904-8iteddug	52	20	position	position	NN
cord-306904-8iteddug	52	21	ascribed	ascribe	VBN
cord-306904-8iteddug	52	22	by	by	IN
cord-306904-8iteddug	52	23	Table	Table	NNP
cord-306904-8iteddug	52	24	1	1	CD
cord-306904-8iteddug	52	25	to	to	IN
cord-306904-8iteddug	52	26	a	a	DT
cord-306904-8iteddug	52	27	protein	protein	NN
cord-306904-8iteddug	52	28	with	with	IN
cord-306904-8iteddug	52	29	the	the	DT
cord-306904-8iteddug	52	30	lowest	low	JJS
cord-306904-8iteddug	52	31	disorder	disorder	NN
cord-306904-8iteddug	52	32	content	content	NN
cord-306904-8iteddug	52	33	.	.	.
cord-306904-8iteddug	53	1	The	the	DT
cord-306904-8iteddug	53	2	corresponding	corresponding	JJ
cord-306904-8iteddug	53	3	sections	section	NNS
cord-306904-8iteddug	53	4	are	be	VBP
cord-306904-8iteddug	53	5	organized	organize	VBN
cord-306904-8iteddug	53	6	in	in	IN
cord-306904-8iteddug	53	7	the	the	DT
cord-306904-8iteddug	53	8	following	following	JJ
cord-306904-8iteddug	53	9	way	way	NN
cord-306904-8iteddug	53	10	:	:	:
cord-306904-8iteddug	53	11	first	first	RB
cord-306904-8iteddug	53	12	,	,	,
cord-306904-8iteddug	53	13	a	a	DT
cord-306904-8iteddug	53	14	brief	brief	JJ
cord-306904-8iteddug	53	15	description	description	NN
cord-306904-8iteddug	53	16	of	of	IN
cord-306904-8iteddug	53	17	the	the	DT
cord-306904-8iteddug	53	18	paper	paper	NN
cord-306904-8iteddug	53	19	is	be	VBZ
cord-306904-8iteddug	53	20	provided	provide	VBN
cord-306904-8iteddug	53	21	;	;	:
cord-306904-8iteddug	53	22	then	then	RB
cord-306904-8iteddug	53	23	,	,	,
cord-306904-8iteddug	53	24	the	the	DT
cord-306904-8iteddug	53	25	biological	biological	JJ
cord-306904-8iteddug	53	26	importance	importance	NN
cord-306904-8iteddug	53	27	of	of	IN
cord-306904-8iteddug	53	28	the	the	DT
cord-306904-8iteddug	53	29	related	related	JJ
cord-306904-8iteddug	53	30	proteins	protein	NNS
cord-306904-8iteddug	53	31	is	be	VBZ
cord-306904-8iteddug	53	32	discussed	discuss	VBN
cord-306904-8iteddug	53	33	;	;	:
cord-306904-8iteddug	53	34	next	next	RB
cord-306904-8iteddug	53	35	,	,	,
cord-306904-8iteddug	53	36	the	the	DT
cord-306904-8iteddug	53	37	results	result	NNS
cord-306904-8iteddug	53	38	of	of	IN
cord-306904-8iteddug	53	39	the	the	DT
cord-306904-8iteddug	53	40	computational	computational	JJ
cord-306904-8iteddug	53	41	and	and	CC
cord-306904-8iteddug	53	42	bioinformatics	bioinformatics	NN
cord-306904-8iteddug	53	43	analyses	analysis	NNS
cord-306904-8iteddug	53	44	of	of	IN
cord-306904-8iteddug	53	45	the	the	DT
cord-306904-8iteddug	53	46	disorder	disorder	NN
cord-306904-8iteddug	53	47	status	status	NN
cord-306904-8iteddug	53	48	of	of	IN
cord-306904-8iteddug	53	49	a	a	DT
cord-306904-8iteddug	53	50	given	give	VBN
cord-306904-8iteddug	53	51	protein	protein	NN
cord-306904-8iteddug	53	52	(	(	-LRB-
cord-306904-8iteddug	53	53	or	or	CC
cord-306904-8iteddug	53	54	set	set	VBN
cord-306904-8iteddug	53	55	of	of	IN
cord-306904-8iteddug	53	56	proteins	protein	NNS
cord-306904-8iteddug	53	57	)	)	-RRB-
cord-306904-8iteddug	53	58	are	be	VBP
cord-306904-8iteddug	53	59	represented	represent	VBN
cord-306904-8iteddug	53	60	to	to	TO
cord-306904-8iteddug	53	61	show	show	VB
cord-306904-8iteddug	53	62	how	how	WRB
cord-306904-8iteddug	53	63	consideration	consideration	NN
cord-306904-8iteddug	53	64	of	of	IN
cord-306904-8iteddug	53	65	intrinsic	intrinsic	JJ
cord-306904-8iteddug	53	66	disorder	disorder	NN
cord-306904-8iteddug	53	67	can	can	MD
cord-306904-8iteddug	53	68	enhance	enhance	VB
cord-306904-8iteddug	53	69	conclusions	conclusion	NNS
cord-306904-8iteddug	53	70	of	of	IN
cord-306904-8iteddug	53	71	a	a	DT
cord-306904-8iteddug	53	72	paper	paper	NN
cord-306904-8iteddug	53	73	.	.	.
cord-306904-8iteddug	54	1	Eukaryotic	eukaryotic	JJ
cord-306904-8iteddug	54	2	translation	translation	NN
cord-306904-8iteddug	54	3	initiation	initiation	NN
cord-306904-8iteddug	54	4	factors	factor	NNS
cord-306904-8iteddug	54	5	4A	4a	CD
cord-306904-8iteddug	54	6	,	,	,
cord-306904-8iteddug	54	7	4B	4b	NN
cord-306904-8iteddug	54	8	and	and	CC
cord-306904-8iteddug	54	9	4	4	CD
cord-306904-8iteddug	54	10	G	g	NN
cord-306904-8iteddug	54	11	(	(	-LRB-
cord-306904-8iteddug	54	12	eIF4A	eIF4A	NNS
cord-306904-8iteddug	54	13	,	,	,
cord-306904-8iteddug	54	14	eIF4B	eif4b	CD
cord-306904-8iteddug	54	15	,	,	,
cord-306904-8iteddug	54	16	and	and	CC
cord-306904-8iteddug	54	17	eIF4	eIF4	NNP
cord-306904-8iteddug	54	18	G	G	NNP
cord-306904-8iteddug	54	19	)	)	-RRB-
cord-306904-8iteddug	55	1	Andreou	Andreou	NNP
cord-306904-8iteddug	55	2	&	&	CC
cord-306904-8iteddug	55	3	Klostermeier	Klostermeier	NNP
cord-306904-8iteddug	55	4	investigated	investigate	VBD
cord-306904-8iteddug	55	5	the	the	DT
cord-306904-8iteddug	55	6	peculiarities	peculiarity	NNS
cord-306904-8iteddug	55	7	of	of	IN
cord-306904-8iteddug	55	8	the	the	DT
cord-306904-8iteddug	55	9	combined	combine	VBN
cord-306904-8iteddug	55	10	action	action	NN
cord-306904-8iteddug	55	11	of	of	IN
cord-306904-8iteddug	55	12	3	3	CD
cord-306904-8iteddug	55	13	eukaryotic	eukaryotic	JJ
cord-306904-8iteddug	55	14	translation	translation	NN
cord-306904-8iteddug	55	15	initiation	initiation	NN
cord-306904-8iteddug	55	16	factors	factor	NNS
cord-306904-8iteddug	55	17	,	,	,
cord-306904-8iteddug	55	18	eIF4A	eIF4A	NNS
cord-306904-8iteddug	55	19	,	,	,
cord-306904-8iteddug	55	20	eIF4B	eif4b	CD
cord-306904-8iteddug	55	21	,	,	,
cord-306904-8iteddug	55	22	and	and	CC
cord-306904-8iteddug	55	23	eIF4	eIF4	NNP
cord-306904-8iteddug	55	24	G	G	NNP
cord-306904-8iteddug	55	25	,	,	,
cord-306904-8iteddug	55	26	in	in	IN
cord-306904-8iteddug	55	27	RNA	RNA	NNP
cord-306904-8iteddug	55	28	unwinding	unwinding	NN
cord-306904-8iteddug	55	29	needed	need	VBN
cord-306904-8iteddug	55	30	to	to	TO
cord-306904-8iteddug	55	31	resolve	resolve	VB
cord-306904-8iteddug	55	32	secondary	secondary	JJ
cord-306904-8iteddug	55	33	structure	structure	NN
cord-306904-8iteddug	55	34	elements	element	NNS
cord-306904-8iteddug	55	35	from	from	IN
cord-306904-8iteddug	55	36	the	the	DT
cord-306904-8iteddug	55	37	5	5	CD
cord-306904-8iteddug	55	38	0	0	CD
cord-306904-8iteddug	55	39	-untranslated	-untranslated	JJ
cord-306904-8iteddug	55	40	region	region	NN
cord-306904-8iteddug	55	41	of	of	IN
cord-306904-8iteddug	55	42	mRNAs	mRNAs	NNPS
cord-306904-8iteddug	55	43	to	to	TO
cord-306904-8iteddug	55	44	enable	enable	VB
cord-306904-8iteddug	55	45	ribosome	ribosome	NN
cord-306904-8iteddug	55	46	scanning	scanning	NN
cord-306904-8iteddug	55	47	.	.	.
cord-306904-8iteddug	56	1	5	5	LS
cord-306904-8iteddug	57	1	A	a	DT
cord-306904-8iteddug	57	2	set	set	NN
cord-306904-8iteddug	57	3	of	of	IN
cord-306904-8iteddug	57	4	eukaryotic	eukaryotic	JJ
cord-306904-8iteddug	57	5	translation	translation	NN
cord-306904-8iteddug	57	6	initiation	initiation	NN
cord-306904-8iteddug	57	7	factors	factor	NNS
cord-306904-8iteddug	57	8	(	(	-LRB-
cord-306904-8iteddug	57	9	eIFs	eifs	NN
cord-306904-8iteddug	57	10	)	)	-RRB-
cord-306904-8iteddug	57	11	is	be	VBZ
cord-306904-8iteddug	57	12	involved	involve	VBN
cord-306904-8iteddug	57	13	in	in	IN
cord-306904-8iteddug	57	14	the	the	DT
cord-306904-8iteddug	57	15	complex	complex	JJ
cord-306904-8iteddug	57	16	,	,	,
cord-306904-8iteddug	57	17	multi	multi	JJ
cord-306904-8iteddug	57	18	-	-	JJ
cord-306904-8iteddug	57	19	stage	stage	JJ
cord-306904-8iteddug	57	20	process	process	NN
cord-306904-8iteddug	57	21	of	of	IN
cord-306904-8iteddug	57	22	initiation	initiation	NN
cord-306904-8iteddug	57	23	of	of	IN
cord-306904-8iteddug	57	24	mRNA	mRNA	NNP
cord-306904-8iteddug	57	25	translation	translation	NN
cord-306904-8iteddug	57	26	in	in	IN
cord-306904-8iteddug	57	27	eukaryotes	eukaryote	NNS
cord-306904-8iteddug	57	28	.	.	.
cord-306904-8iteddug	58	1	In	in	IN
cord-306904-8iteddug	58	2	the	the	DT
cord-306904-8iteddug	58	3	first	first	JJ
cord-306904-8iteddug	58	4	step	step	NN
cord-306904-8iteddug	58	5	of	of	IN
cord-306904-8iteddug	58	6	this	this	DT
cord-306904-8iteddug	58	7	process	process	NN
cord-306904-8iteddug	58	8	,	,	,
cord-306904-8iteddug	58	9	the	the	DT
cord-306904-8iteddug	58	10	eIF4F	eif4f	CD
cord-306904-8iteddug	58	11	complex	complex	NN
cord-306904-8iteddug	58	12	binds	bind	VBZ
cord-306904-8iteddug	58	13	to	to	IN
cord-306904-8iteddug	58	14	the	the	DT
cord-306904-8iteddug	58	15	m7	m7	NN
cord-306904-8iteddug	58	16	Gppp	Gppp	NNP
cord-306904-8iteddug	58	17	cap	cap	NN
cord-306904-8iteddug	58	18	on	on	IN
cord-306904-8iteddug	58	19	the	the	DT
cord-306904-8iteddug	58	20	5	5	CD
cord-306904-8iteddug	58	21	0	0	CD
cord-306904-8iteddug	58	22	-end	-end	:
cord-306904-8iteddug	58	23	of	of	IN
cord-306904-8iteddug	58	24	the	the	DT
cord-306904-8iteddug	58	25	mRNA	mrna	NN
cord-306904-8iteddug	58	26	.	.	.
cord-306904-8iteddug	59	1	This	this	DT
cord-306904-8iteddug	59	2	eIF4F	eif4f	CD
cord-306904-8iteddug	59	3	complex	complex	NN
cord-306904-8iteddug	59	4	consists	consist	VBZ
cord-306904-8iteddug	59	5	of	of	IN
cord-306904-8iteddug	59	6	the	the	DT
cord-306904-8iteddug	59	7	cap	cap	NN
cord-306904-8iteddug	59	8	-	-	HYPH
cord-306904-8iteddug	59	9	binding	bind	VBG
cord-306904-8iteddug	59	10	protein	protein	NN
cord-306904-8iteddug	59	11	eIF4E	eif4e	CD
cord-306904-8iteddug	59	12	,	,	,
cord-306904-8iteddug	59	13	the	the	DT
cord-306904-8iteddug	59	14	scaffolding	scaffolding	NN
cord-306904-8iteddug	59	15	protein	protein	NN
cord-306904-8iteddug	59	16	eIF4	eif4	IN
cord-306904-8iteddug	59	17	G	G	NNP
cord-306904-8iteddug	59	18	,	,	,
cord-306904-8iteddug	59	19	and	and	CC
cord-306904-8iteddug	59	20	the	the	DT
cord-306904-8iteddug	59	21	DEADbox	deadbox	NN
cord-306904-8iteddug	59	22	helicase	helicase	NNP
cord-306904-8iteddug	59	23	eIF4A.	eIF4A.	NNP
cord-306904-8iteddug	59	24	6	6	CD
cord-306904-8iteddug	59	25	,	,	,
cord-306904-8iteddug	59	26	7	7	CD
cord-306904-8iteddug	60	1	At	at	IN
cord-306904-8iteddug	60	2	the	the	DT
cord-306904-8iteddug	60	3	next	next	JJ
cord-306904-8iteddug	60	4	steps	step	NNS
cord-306904-8iteddug	60	5	of	of	IN
cord-306904-8iteddug	60	6	the	the	DT
cord-306904-8iteddug	60	7	translation	translation	NN
cord-306904-8iteddug	60	8	initiation	initiation	NN
cord-306904-8iteddug	60	9	,	,	,
cord-306904-8iteddug	60	10	the	the	DT
cord-306904-8iteddug	60	11	eIF4F	eif4f	CD
cord-306904-8iteddug	60	12	complex	complex	JJ
cord-306904-8iteddug	60	13	recruits	recruit	VBZ
cord-306904-8iteddug	60	14	the	the	DT
cord-306904-8iteddug	60	15	43S	43s	JJ
cord-306904-8iteddug	60	16	ribosomal	ribosomal	JJ
cord-306904-8iteddug	60	17	preinitiation	preinitiation	NN
cord-306904-8iteddug	60	18	complex	complex	NN
cord-306904-8iteddug	60	19	which	which	WDT
cord-306904-8iteddug	60	20	scans	scan	VBZ
cord-306904-8iteddug	60	21	the	the	DT
cord-306904-8iteddug	60	22	5	5	CD
cord-306904-8iteddug	60	23	0untranslated	0untranslated	CD
cord-306904-8iteddug	60	24	region	region	NN
cord-306904-8iteddug	60	25	in	in	IN
cord-306904-8iteddug	60	26	5	5	CD
cord-306904-8iteddug	60	27	0	0	CD
cord-306904-8iteddug	60	28	-to-3	-to-3	CD
cord-306904-8iteddug	60	29	0	0	CD
cord-306904-8iteddug	60	30	direction	direction	NN
cord-306904-8iteddug	60	31	in	in	IN
cord-306904-8iteddug	60	32	search	search	NN
cord-306904-8iteddug	60	33	for	for	IN
cord-306904-8iteddug	60	34	the	the	DT
cord-306904-8iteddug	60	35	translation	translation	NN
cord-306904-8iteddug	60	36	start	start	NN
cord-306904-8iteddug	60	37	codon	codon	NNP
cord-306904-8iteddug	60	38	.	.	.
cord-306904-8iteddug	61	1	8	8	CD
cord-306904-8iteddug	61	2	,	,	,
cord-306904-8iteddug	61	3	9	9	CD
cord-306904-8iteddug	61	4	One	one	CD
cord-306904-8iteddug	61	5	of	of	IN
cord-306904-8iteddug	61	6	the	the	DT
cord-306904-8iteddug	61	7	important	important	JJ
cord-306904-8iteddug	61	8	points	point	NNS
cord-306904-8iteddug	61	9	in	in	IN
cord-306904-8iteddug	61	10	this	this	DT
cord-306904-8iteddug	61	11	process	process	NN
cord-306904-8iteddug	61	12	is	be	VBZ
cord-306904-8iteddug	61	13	the	the	DT
cord-306904-8iteddug	61	14	resolution	resolution	NN
cord-306904-8iteddug	61	15	of	of	IN
cord-306904-8iteddug	61	16	secondary	secondary	JJ
cord-306904-8iteddug	61	17	and	and	CC
cord-306904-8iteddug	61	18	tertiary	tertiary	JJ
cord-306904-8iteddug	61	19	structures	structure	NNS
cord-306904-8iteddug	61	20	in	in	IN
cord-306904-8iteddug	61	21	the	the	DT
cord-306904-8iteddug	61	22	mRNA	mrna	NN
cord-306904-8iteddug	61	23	,	,	,
cord-306904-8iteddug	61	24	which	which	WDT
cord-306904-8iteddug	61	25	is	be	VBZ
cord-306904-8iteddug	61	26	typically	typically	RB
cord-306904-8iteddug	61	27	done	do	VBN
cord-306904-8iteddug	61	28	by	by	IN
cord-306904-8iteddug	61	29	the	the	DT
cord-306904-8iteddug	61	30	DEAD	DEAD	NNP
cord-306904-8iteddug	61	31	-	-	HYPH
cord-306904-8iteddug	61	32	box	box	NN
cord-306904-8iteddug	61	33	helicase	helicase	NN
cord-306904-8iteddug	61	34	eIF4A	eif4a	NN
cord-306904-8iteddug	61	35	,	,	,
cord-306904-8iteddug	61	36	which	which	WDT
cord-306904-8iteddug	61	37	possesses	possess	VBZ
cord-306904-8iteddug	61	38	RNA	rna	NN
cord-306904-8iteddug	61	39	-	-	HYPH
cord-306904-8iteddug	61	40	dependent	dependent	JJ
cord-306904-8iteddug	61	41	ATPase	ATPase	NNP
cord-306904-8iteddug	61	42	and	and	CC
cord-306904-8iteddug	61	43	ATP	ATP	NNP
cord-306904-8iteddug	61	44	-	-	HYPH
cord-306904-8iteddug	61	45	dependent	dependent	JJ
cord-306904-8iteddug	61	46	RNA	RNA	NNP
cord-306904-8iteddug	61	47	helicase	helicase	NN
cord-306904-8iteddug	61	48	activities	activity	NNS
cord-306904-8iteddug	61	49	.	.	.
cord-306904-8iteddug	62	1	10	10	CD
cord-306904-8iteddug	63	1	These	these	DT
cord-306904-8iteddug	63	2	2	2	CD
cord-306904-8iteddug	63	3	activities	activity	NNS
cord-306904-8iteddug	63	4	of	of	IN
cord-306904-8iteddug	63	5	eIF4A	eIF4A	NNS
cord-306904-8iteddug	63	6	are	be	VBP
cord-306904-8iteddug	63	7	enhanced	enhance	VBN
cord-306904-8iteddug	63	8	by	by	IN
cord-306904-8iteddug	63	9	some	some	DT
cord-306904-8iteddug	63	10	auxiliary	auxiliary	JJ
cord-306904-8iteddug	63	11	proteins	protein	NNS
cord-306904-8iteddug	63	12	,	,	,
cord-306904-8iteddug	63	13	such	such	JJ
cord-306904-8iteddug	63	14	as	as	IN
cord-306904-8iteddug	63	15	eIF4B	eif4b	CD
cord-306904-8iteddug	63	16	and	and	CC
cord-306904-8iteddug	63	17	eIF4	eIF4	NNP
cord-306904-8iteddug	63	18	G	G	NNP
cord-306904-8iteddug	63	19	that	that	WDT
cord-306904-8iteddug	63	20	act	act	NN
cord-306904-8iteddug	63	21	synergistically	synergistically	RB
cord-306904-8iteddug	63	22	stimulating	stimulate	VBG
cord-306904-8iteddug	63	23	the	the	DT
cord-306904-8iteddug	63	24	eIF4A	eif4a	NN
cord-306904-8iteddug	63	25	helicase	helicase	NN
cord-306904-8iteddug	63	26	activity	activity	NN
cord-306904-8iteddug	63	27	in	in	IN
cord-306904-8iteddug	63	28	the	the	DT
cord-306904-8iteddug	63	29	mRNA	mrna	NN
cord-306904-8iteddug	63	30	scanning	scanning	NN
cord-306904-8iteddug	63	31	process	process	NN
cord-306904-8iteddug	63	32	.	.	.
cord-306904-8iteddug	64	1	5	5	CD
cord-306904-8iteddug	64	2	Figure	figure	NN
cord-306904-8iteddug	64	3	1	1	CD
cord-306904-8iteddug	64	4	illustrates	illustrate	VBZ
cord-306904-8iteddug	64	5	the	the	DT
cord-306904-8iteddug	64	6	disorder	disorder	NN
cord-306904-8iteddug	64	7	propensities	propensity	NNS
cord-306904-8iteddug	64	8	of	of	IN
cord-306904-8iteddug	64	9	the	the	DT
cord-306904-8iteddug	64	10	3	3	CD
cord-306904-8iteddug	64	11	proteins	protein	NNS
cord-306904-8iteddug	64	12	related	relate	VBN
cord-306904-8iteddug	64	13	to	to	IN
cord-306904-8iteddug	64	14	the	the	DT
cord-306904-8iteddug	64	15	mRNA	mrna	NN
cord-306904-8iteddug	64	16	unwinding	unwind	VBG
cord-306904-8iteddug	64	17	.	.	.
cord-306904-8iteddug	65	1	Disorder	disorder	NN
cord-306904-8iteddug	65	2	was	be	VBD
cord-306904-8iteddug	65	3	evaluated	evaluate	VBN
cord-306904-8iteddug	65	4	by	by	IN
cord-306904-8iteddug	65	5	a	a	DT
cord-306904-8iteddug	65	6	family	family	NN
cord-306904-8iteddug	65	7	of	of	IN
cord-306904-8iteddug	65	8	PONDR	PONDR	NNP
cord-306904-8iteddug	65	9	predictors	predictor	NNS
cord-306904-8iteddug	65	10	.	.	.
cord-306904-8iteddug	66	1	Here	here	RB
cord-306904-8iteddug	66	2	,	,	,
cord-306904-8iteddug	66	3	scores	score	NNS
cord-306904-8iteddug	66	4	above	above	IN
cord-306904-8iteddug	66	5	0.5	0.5	CD
cord-306904-8iteddug	66	6	correspond	correspond	VBP
cord-306904-8iteddug	66	7	to	to	IN
cord-306904-8iteddug	66	8	disordered	disordered	JJ
cord-306904-8iteddug	66	9	residues	residue	NNS
cord-306904-8iteddug	66	10	/	/	SYM
cord-306904-8iteddug	66	11	regions	region	NNS
cord-306904-8iteddug	66	12	.	.	.
cord-306904-8iteddug	67	1	PONDR	PONDR	NNP
cord-306904-8iteddug	67	2	Ò	Ò	NNP
cord-306904-8iteddug	67	3	VSL2B	vsl2b	NN
cord-306904-8iteddug	67	4	is	be	VBZ
cord-306904-8iteddug	67	5	one	one	CD
cord-306904-8iteddug	67	6	of	of	IN
cord-306904-8iteddug	67	7	the	the	DT
cord-306904-8iteddug	67	8	most	most	RBS
cord-306904-8iteddug	67	9	accurate	accurate	JJ
cord-306904-8iteddug	67	10	standalone	standalone	JJ
cord-306904-8iteddug	67	11	disorder	disorder	NN
cord-306904-8iteddug	67	12	predictors	predictor	NNS
cord-306904-8iteddug	67	13	,	,	,
cord-306904-8iteddug	68	1	11	11	CD
cord-306904-8iteddug	68	2	PONDR	PONDR	NNP
cord-306904-8iteddug	68	3	Ò	Ò	NNP
cord-306904-8iteddug	68	4	VL3	vl3	NN
cord-306904-8iteddug	68	5	possesses	possess	VBZ
cord-306904-8iteddug	68	6	high	high	JJ
cord-306904-8iteddug	68	7	accuracy	accuracy	NN
cord-306904-8iteddug	68	8	in	in	IN
cord-306904-8iteddug	68	9	finding	find	VBG
cord-306904-8iteddug	68	10	long	long	JJ
cord-306904-8iteddug	68	11	IDPRs	idpr	NNS
cord-306904-8iteddug	68	12	,	,	,
cord-306904-8iteddug	69	1	12	12	CD
cord-306904-8iteddug	69	2	PONDR	PONDR	NNP
cord-306904-8iteddug	69	3	Ò	ò	NN
cord-306904-8iteddug	69	4	VLXT	VLXT	NNP
cord-306904-8iteddug	69	5	is	be	VBZ
cord-306904-8iteddug	69	6	not	not	RB
cord-306904-8iteddug	69	7	the	the	DT
cord-306904-8iteddug	69	8	most	most	RBS
cord-306904-8iteddug	69	9	accurate	accurate	JJ
cord-306904-8iteddug	69	10	predictor	predictor	NN
cord-306904-8iteddug	69	11	but	but	CC
cord-306904-8iteddug	69	12	has	have	VBZ
cord-306904-8iteddug	69	13	high	high	JJ
cord-306904-8iteddug	69	14	sensitivity	sensitivity	NN
cord-306904-8iteddug	69	15	to	to	IN
cord-306904-8iteddug	69	16	local	local	JJ
cord-306904-8iteddug	69	17	sequence	sequence	NN
cord-306904-8iteddug	69	18	peculiarities	peculiarity	NNS
cord-306904-8iteddug	69	19	which	which	WDT
cord-306904-8iteddug	69	20	are	be	VBP
cord-306904-8iteddug	69	21	often	often	RB
cord-306904-8iteddug	69	22	associated	associate	VBN
cord-306904-8iteddug	69	23	with	with	IN
cord-306904-8iteddug	69	24	disorderbased	disorderbased	JJ
cord-306904-8iteddug	69	25	interaction	interaction	NN
cord-306904-8iteddug	69	26	sites	site	NNS
cord-306904-8iteddug	69	27	,	,	,
cord-306904-8iteddug	69	28	13	13	CD
cord-306904-8iteddug	69	29	whereas	whereas	IN
cord-306904-8iteddug	69	30	PONDR	PONDR	NNP
cord-306904-8iteddug	69	31	-	-	HYPH
cord-306904-8iteddug	69	32	FIT	FIT	NNP
cord-306904-8iteddug	69	33	represents	represent	VBZ
cord-306904-8iteddug	69	34	a	a	DT
cord-306904-8iteddug	69	35	metapredictor	metapredictor	NN
cord-306904-8iteddug	69	36	which	which	WDT
cord-306904-8iteddug	69	37	,	,	,
cord-306904-8iteddug	69	38	being	be	VBG
cord-306904-8iteddug	69	39	moderately	moderately	RB
cord-306904-8iteddug	69	40	more	more	RBR
cord-306904-8iteddug	69	41	accurate	accurate	JJ
cord-306904-8iteddug	69	42	than	than	IN
cord-306904-8iteddug	69	43	each	each	DT
cord-306904-8iteddug	69	44	of	of	IN
cord-306904-8iteddug	69	45	the	the	DT
cord-306904-8iteddug	69	46	component	component	NN
cord-306904-8iteddug	69	47	predictors	predictor	NNS
cord-306904-8iteddug	69	48	,	,	,
cord-306904-8iteddug	69	49	is	be	VBZ
cord-306904-8iteddug	69	50	one	one	CD
cord-306904-8iteddug	69	51	of	of	IN
cord-306904-8iteddug	69	52	the	the	DT
cord-306904-8iteddug	69	53	most	most	RBS
cord-306904-8iteddug	69	54	accurate	accurate	JJ
cord-306904-8iteddug	69	55	disorder	disorder	NN
cord-306904-8iteddug	69	56	predictors	predictor	NNS
cord-306904-8iteddug	69	57	.	.	.
cord-306904-8iteddug	70	1	14	14	CD
cord-306904-8iteddug	71	1	The	the	DT
cord-306904-8iteddug	71	2	various	various	JJ
cord-306904-8iteddug	71	3	predictors	predictor	NNS
cord-306904-8iteddug	71	4	often	often	RB
cord-306904-8iteddug	71	5	give	give	VBP
cord-306904-8iteddug	71	6	different	different	JJ
cord-306904-8iteddug	71	7	predictions	prediction	NNS
cord-306904-8iteddug	71	8	of	of	IN
cord-306904-8iteddug	71	9	disorder	disorder	NN
cord-306904-8iteddug	71	10	for	for	IN
cord-306904-8iteddug	71	11	the	the	DT
cord-306904-8iteddug	71	12	same	same	JJ
cord-306904-8iteddug	71	13	protein	protein	NN
cord-306904-8iteddug	71	14	,	,	,
cord-306904-8iteddug	71	15	perhaps	perhaps	RB
cord-306904-8iteddug	71	16	leading	lead	VBG
cord-306904-8iteddug	71	17	so	so	RB
cord-306904-8iteddug	71	18	some	some	DT
cord-306904-8iteddug	71	19	confusion	confusion	NN
cord-306904-8iteddug	71	20	when	when	WRB
cord-306904-8iteddug	71	21	trying	try	VBG
cord-306904-8iteddug	71	22	to	to	TO
cord-306904-8iteddug	71	23	understand	understand	VB
cord-306904-8iteddug	71	24	the	the	DT
cord-306904-8iteddug	71	25	implications	implication	NNS
cord-306904-8iteddug	71	26	of	of	IN
cord-306904-8iteddug	71	27	this	this	DT
cord-306904-8iteddug	71	28	and	and	CC
cord-306904-8iteddug	71	29	the	the	DT
cord-306904-8iteddug	71	30	following	follow	VBG
cord-306904-8iteddug	71	31	figures	figure	NNS
cord-306904-8iteddug	71	32	.	.	.
cord-306904-8iteddug	72	1	These	these	DT
cord-306904-8iteddug	72	2	differences	difference	NNS
cord-306904-8iteddug	72	3	arise	arise	VBP
cord-306904-8iteddug	72	4	because	because	IN
cord-306904-8iteddug	72	5	of	of	IN
cord-306904-8iteddug	72	6	different	different	JJ
cord-306904-8iteddug	72	7	computational	computational	JJ
cord-306904-8iteddug	72	8	methods	method	NNS
cord-306904-8iteddug	72	9	and	and	CC
cord-306904-8iteddug	72	10	especially	especially	RB
cord-306904-8iteddug	72	11	because	because	IN
cord-306904-8iteddug	72	12	different	different	JJ
cord-306904-8iteddug	72	13	training	training	NN
cord-306904-8iteddug	72	14	sets	set	NNS
cord-306904-8iteddug	72	15	were	be	VBD
cord-306904-8iteddug	72	16	used	use	VBN
cord-306904-8iteddug	72	17	.	.	.
cord-306904-8iteddug	73	1	Despite	despite	IN
cord-306904-8iteddug	73	2	the	the	DT
cord-306904-8iteddug	73	3	differences	difference	NNS
cord-306904-8iteddug	73	4	,	,	,
cord-306904-8iteddug	73	5	the	the	DT
cord-306904-8iteddug	73	6	overall	overall	JJ
cord-306904-8iteddug	73	7	disorder	disorder	NN
cord-306904-8iteddug	73	8	prediction	prediction	NN
cord-306904-8iteddug	73	9	trends	trend	NNS
cord-306904-8iteddug	73	10	are	be	VBP
cord-306904-8iteddug	73	11	typically	typically	RB
cord-306904-8iteddug	73	12	similar	similar	JJ
cord-306904-8iteddug	73	13	for	for	IN
cord-306904-8iteddug	73	14	each	each	DT
cord-306904-8iteddug	73	15	protein	protein	NN
cord-306904-8iteddug	73	16	.	.	.
cord-306904-8iteddug	74	1	In	in	IN
cord-306904-8iteddug	74	2	agreement	agreement	NN
cord-306904-8iteddug	74	3	with	with	IN
cord-306904-8iteddug	74	4	the	the	DT
cord-306904-8iteddug	74	5	notion	notion	NN
cord-306904-8iteddug	74	6	that	that	IN
cord-306904-8iteddug	74	7	catalytic	catalytic	JJ
cord-306904-8iteddug	74	8	functions	function	NNS
cord-306904-8iteddug	74	9	require	require	VBP
cord-306904-8iteddug	74	10	specific	specific	JJ
cord-306904-8iteddug	74	11	and	and	CC
cord-306904-8iteddug	74	12	ordered	order	VBN
cord-306904-8iteddug	74	13	structure	structure	NN
cord-306904-8iteddug	74	14	,	,	,
cord-306904-8iteddug	74	15	eIF4A	eif4a	UH
cord-306904-8iteddug	74	16	,	,	,
cord-306904-8iteddug	74	17	with	with	IN
cord-306904-8iteddug	74	18	its	-PRON-	PRP$
cord-306904-8iteddug	74	19	ATPase	ATPase	NNP
cord-306904-8iteddug	74	20	and	and	CC
cord-306904-8iteddug	74	21	ATP	ATP	NNP
cord-306904-8iteddug	74	22	-	-	HYPH
cord-306904-8iteddug	74	23	dependent	dependent	JJ
cord-306904-8iteddug	74	24	RNA	RNA	NNP
cord-306904-8iteddug	74	25	helicase	helicase	NN
cord-306904-8iteddug	74	26	activities	activity	NNS
cord-306904-8iteddug	74	27	,	,	,
cord-306904-8iteddug	74	28	is	be	VBZ
cord-306904-8iteddug	74	29	predicted	predict	VBN
cord-306904-8iteddug	74	30	to	to	TO
cord-306904-8iteddug	74	31	be	be	VB
cord-306904-8iteddug	74	32	mostly	mostly	RB
cord-306904-8iteddug	74	33	ordered	order	VBN
cord-306904-8iteddug	74	34	protein	protein	NN
cord-306904-8iteddug	74	35	(	(	-LRB-
cord-306904-8iteddug	74	36	see	see	VB
cord-306904-8iteddug	74	37	Fig	Fig	NNP
cord-306904-8iteddug	74	38	.	.	.
cord-306904-8iteddug	74	39	1A	1a	NN
cord-306904-8iteddug	74	40	;	;	:
cord-306904-8iteddug	74	41	UniProt	UniProt	NNP
cord-306904-8iteddug	74	42	ID	ID	NNP
cord-306904-8iteddug	74	43	:	:	:
cord-306904-8iteddug	75	1	P10081	P10081	NNP
cord-306904-8iteddug	75	2	)	)	-RRB-
cord-306904-8iteddug	75	3	.	.	.
cord-306904-8iteddug	76	1	The	the	DT
cord-306904-8iteddug	76	2	mostly	mostly	RB
cord-306904-8iteddug	76	3	ordered	order	VBN
cord-306904-8iteddug	76	4	nature	nature	NN
cord-306904-8iteddug	76	5	of	of	IN
cord-306904-8iteddug	76	6	this	this	DT
cord-306904-8iteddug	76	7	enzyme	enzyme	NN
cord-306904-8iteddug	76	8	is	be	VBZ
cord-306904-8iteddug	76	9	further	further	RB
cord-306904-8iteddug	76	10	supported	support	VBN
cord-306904-8iteddug	76	11	by	by	IN
cord-306904-8iteddug	76	12	the	the	DT
cord-306904-8iteddug	76	13	fact	fact	NN
cord-306904-8iteddug	76	14	that	that	IN
cord-306904-8iteddug	76	15	almost	almost	RB
cord-306904-8iteddug	76	16	entire	entire	JJ
cord-306904-8iteddug	76	17	sequence	sequence	NN
cord-306904-8iteddug	76	18	is	be	VBZ
cord-306904-8iteddug	76	19	seen	see	VBN
cord-306904-8iteddug	76	20	in	in	IN
cord-306904-8iteddug	76	21	the	the	DT
cord-306904-8iteddug	76	22	crystal	crystal	NN
cord-306904-8iteddug	76	23	structure	structure	NN
cord-306904-8iteddug	76	24	(	(	-LRB-
cord-306904-8iteddug	76	25	see	see	VB
cord-306904-8iteddug	76	26	red	red	JJ
cord-306904-8iteddug	76	27	structure	structure	NN
cord-306904-8iteddug	76	28	at	at	IN
cord-306904-8iteddug	76	29	Fig	Fig	NNP
cord-306904-8iteddug	76	30	.	.	.
cord-306904-8iteddug	77	1	1B	1B	NNP
cord-306904-8iteddug	77	2	,	,	,
cord-306904-8iteddug	77	3	PDB	PDB	NNP
cord-306904-8iteddug	77	4	ID	ID	NNP
cord-306904-8iteddug	77	5	:	:	:
cord-306904-8iteddug	77	6	2VSO	2VSO	NNP
cord-306904-8iteddug	77	7	)	)	-RRB-
cord-306904-8iteddug	77	8	,	,	,
cord-306904-8iteddug	77	9	except	except	IN
cord-306904-8iteddug	77	10	to	to	IN
cord-306904-8iteddug	77	11	the	the	DT
cord-306904-8iteddug	77	12	residues	residue	NNS
cord-306904-8iteddug	77	13	1	1	CD
cord-306904-8iteddug	77	14	-	-	SYM
cord-306904-8iteddug	77	15	11	11	CD
cord-306904-8iteddug	77	16	,	,	,
cord-306904-8iteddug	77	17	126	126	CD
cord-306904-8iteddug	77	18	-	-	SYM
cord-306904-8iteddug	77	19	135	135	CD
cord-306904-8iteddug	77	20	,	,	,
cord-306904-8iteddug	77	21	351	351	CD
cord-306904-8iteddug	77	22	-	-	SYM
cord-306904-8iteddug	77	23	356	356	CD
cord-306904-8iteddug	77	24	,	,	,
cord-306904-8iteddug	77	25	and	and	CC
cord-306904-8iteddug	77	26	394	394	CD
cord-306904-8iteddug	77	27	-	-	SYM
cord-306904-8iteddug	77	28	395	395	CD
cord-306904-8iteddug	77	29	.	.	.
cord-306904-8iteddug	78	1	On	on	IN
cord-306904-8iteddug	78	2	the	the	DT
cord-306904-8iteddug	78	3	contrary	contrary	NN
cord-306904-8iteddug	78	4	,	,	,
cord-306904-8iteddug	78	5	the	the	DT
cord-306904-8iteddug	78	6	auxiliary	auxiliary	JJ
cord-306904-8iteddug	78	7	proteins	protein	NNS
cord-306904-8iteddug	78	8	eIF4B	eif4b	CD
cord-306904-8iteddug	78	9	and	and	CC
cord-306904-8iteddug	78	10	eIF4	eIF4	NNP
cord-306904-8iteddug	78	11	G	G	NNP
cord-306904-8iteddug	78	12	are	be	VBP
cord-306904-8iteddug	78	13	predicted	predict	VBN
cord-306904-8iteddug	78	14	to	to	TO
cord-306904-8iteddug	78	15	possess	possess	VB
cord-306904-8iteddug	78	16	long	long	JJ
cord-306904-8iteddug	78	17	disordered	disordered	JJ
cord-306904-8iteddug	78	18	regions	region	NNS
cord-306904-8iteddug	78	19	(	(	-LRB-
cord-306904-8iteddug	78	20	see	see	VB
cord-306904-8iteddug	78	21	Figs	fig	NNS
cord-306904-8iteddug	78	22	.	.	.
cord-306904-8iteddug	79	1	1C	1C	NNP
cord-306904-8iteddug	79	2	and	and	CC
cord-306904-8iteddug	79	3	1D	1d	CD
cord-306904-8iteddug	79	4	;	;	:
cord-306904-8iteddug	79	5	UniProt	UniProt	NNP
cord-306904-8iteddug	79	6	IDs	id	NNS
cord-306904-8iteddug	79	7	:	:	:
cord-306904-8iteddug	79	8	P34167	P34167	NNP
cord-306904-8iteddug	79	9	and	and	CC
cord-306904-8iteddug	79	10	P39935	P39935	NNP
cord-306904-8iteddug	79	11	,	,	,
cord-306904-8iteddug	79	12	respectively	respectively	RB
cord-306904-8iteddug	79	13	)	)	-RRB-
cord-306904-8iteddug	79	14	.	.	.
cord-306904-8iteddug	80	1	eIF4	eif4	IN
cord-306904-8iteddug	80	2	G	G	NNP
cord-306904-8iteddug	80	3	is	be	VBZ
cord-306904-8iteddug	80	4	also	also	RB
cord-306904-8iteddug	80	5	predicted	predict	VBN
cord-306904-8iteddug	80	6	to	to	TO
cord-306904-8iteddug	80	7	have	have	VB
cord-306904-8iteddug	80	8	an	an	DT
cord-306904-8iteddug	80	9	ordered	order	VBN
cord-306904-8iteddug	80	10	region	region	NN
cord-306904-8iteddug	80	11	that	that	WDT
cord-306904-8iteddug	80	12	coincides	coincide	VBZ
cord-306904-8iteddug	80	13	with	with	IN
cord-306904-8iteddug	80	14	its	-PRON-	PRP$
cord-306904-8iteddug	80	15	middle	middle	NN
cord-306904-8iteddug	80	16	or	or	CC
cord-306904-8iteddug	80	17	eIF4A	eif4a	NN
cord-306904-8iteddug	80	18	interacting	interact	VBG
cord-306904-8iteddug	80	19	domain	domain	NN
cord-306904-8iteddug	80	20	(	(	-LRB-
cord-306904-8iteddug	80	21	residues	residue	NNS
cord-306904-8iteddug	80	22	571	571	CD
cord-306904-8iteddug	80	23	-	-	HYPH
cord-306904-8iteddug	80	24	854	854	CD
cord-306904-8iteddug	80	25	)	)	-RRB-
cord-306904-8iteddug	80	26	.	.	.
cord-306904-8iteddug	81	1	This	this	DT
cord-306904-8iteddug	81	2	region	region	NN
cord-306904-8iteddug	81	3	was	be	VBD
cord-306904-8iteddug	81	4	cocrystallized	cocrystallize	VBN
cord-306904-8iteddug	81	5	with	with	IN
cord-306904-8iteddug	81	6	the	the	DT
cord-306904-8iteddug	81	7	eIF4A	eif4a	CD
cord-306904-8iteddug	81	8	factor	factor	NN
cord-306904-8iteddug	81	9	(	(	-LRB-
cord-306904-8iteddug	81	10	see	see	VB
cord-306904-8iteddug	81	11	blue	blue	JJ
cord-306904-8iteddug	81	12	structure	structure	NN
cord-306904-8iteddug	81	13	at	at	IN
cord-306904-8iteddug	81	14	Fig	Fig	NNP
cord-306904-8iteddug	81	15	.	.	.
cord-306904-8iteddug	81	16	1B	1b	CD
cord-306904-8iteddug	81	17	)	)	-RRB-
cord-306904-8iteddug	81	18	.	.	.
cord-306904-8iteddug	82	1	Curiously	curiously	RB
cord-306904-8iteddug	82	2	,	,	,
cord-306904-8iteddug	82	3	several	several	JJ
cord-306904-8iteddug	82	4	eIF4	eif4	IN
cord-306904-8iteddug	82	5	G	g	NN
cord-306904-8iteddug	82	6	regions	region	NNS
cord-306904-8iteddug	82	7	were	be	VBD
cord-306904-8iteddug	82	8	missing	miss	VBG
cord-306904-8iteddug	82	9	in	in	IN
cord-306904-8iteddug	82	10	structure	structure	NN
cord-306904-8iteddug	82	11	of	of	IN
cord-306904-8iteddug	82	12	the	the	DT
cord-306904-8iteddug	82	13	eIF4A	eIF4A	NNS
cord-306904-8iteddug	82	14	-	-	:
cord-306904-8iteddug	82	15	eIF4	eif4	NN
cord-306904-8iteddug	82	16	G	g	NN
cord-306904-8iteddug	82	17	complex	complex	NN
cord-306904-8iteddug	82	18	(	(	-LRB-
cord-306904-8iteddug	82	19	e.g.	e.g.	RB
cord-306904-8iteddug	82	20	,	,	,
cord-306904-8iteddug	82	21	residues	residue	NNS
cord-306904-8iteddug	82	22	571	571	CD
cord-306904-8iteddug	82	23	-	-	SYM
cord-306904-8iteddug	82	24	576	576	CD
cord-306904-8iteddug	82	25	,	,	,
cord-306904-8iteddug	82	26	583	583	CD
cord-306904-8iteddug	82	27	-	-	SYM
cord-306904-8iteddug	82	28	596	596	CD
cord-306904-8iteddug	82	29	,	,	,
cord-306904-8iteddug	82	30	686	686	CD
cord-306904-8iteddug	82	31	-	-	SYM
cord-306904-8iteddug	82	32	688	688	CD
cord-306904-8iteddug	82	33	,	,	,
cord-306904-8iteddug	82	34	717	717	CD
cord-306904-8iteddug	82	35	-	-	SYM
cord-306904-8iteddug	82	36	729	729	CD
cord-306904-8iteddug	82	37	,	,	,
cord-306904-8iteddug	82	38	803	803	CD
cord-306904-8iteddug	82	39	-	-	SYM
cord-306904-8iteddug	82	40	811	811	CD
cord-306904-8iteddug	82	41	,	,	,
cord-306904-8iteddug	82	42	and	and	CC
cord-306904-8iteddug	82	43	853	853	CD
cord-306904-8iteddug	82	44	-	-	HYPH
cord-306904-8iteddug	82	45	854	854	CD
cord-306904-8iteddug	82	46	)	)	-RRB-
cord-306904-8iteddug	82	47	.	.	.
cord-306904-8iteddug	83	1	Long	long	RB
cord-306904-8iteddug	83	2	intrinsically	intrinsically	RB
cord-306904-8iteddug	83	3	disordered	disordered	JJ
cord-306904-8iteddug	83	4	regions	region	NNS
cord-306904-8iteddug	83	5	are	be	VBP
cord-306904-8iteddug	83	6	important	important	JJ
cord-306904-8iteddug	83	7	for	for	IN
cord-306904-8iteddug	83	8	functions	function	NNS
cord-306904-8iteddug	83	9	of	of	IN
cord-306904-8iteddug	83	10	eIF4B	eif4b	DT
cord-306904-8iteddug	83	11	and	and	CC
cord-306904-8iteddug	83	12	eIF4G.	eIF4G.	.
cord-306904-8iteddug	84	1	In	in	IN
cord-306904-8iteddug	84	2	fact	fact	NN
cord-306904-8iteddug	84	3	,	,	,
cord-306904-8iteddug	84	4	according	accord	VBG
cord-306904-8iteddug	84	5	to	to	IN
cord-306904-8iteddug	84	6	ANCHOR	ANCHOR	NNP
cord-306904-8iteddug	84	7	,	,	,
cord-306904-8iteddug	84	8	15	15	CD
cord-306904-8iteddug	84	9	Human	human	JJ
cord-306904-8iteddug	84	10	plasminogen	plasminogen	NN
cord-306904-8iteddug	84	11	activator	activator	NN
cord-306904-8iteddug	84	12	inhibitor	inhibitor	NN
cord-306904-8iteddug	84	13	1	1	CD
cord-306904-8iteddug	84	14	(	(	-LRB-
cord-306904-8iteddug	84	15	PAI-1	PAI-1	NNP
cord-306904-8iteddug	84	16	)	)	-RRB-
cord-306904-8iteddug	85	1	Florova	Florova	NNP
cord-306904-8iteddug	85	2	et	et	FW
cord-306904-8iteddug	85	3	al	al	NNP
cord-306904-8iteddug	85	4	.	.	NNP
cord-306904-8iteddug	85	5	investigated	investigate	VBD
cord-306904-8iteddug	85	6	the	the	DT
cord-306904-8iteddug	85	7	mechanisms	mechanism	NNS
cord-306904-8iteddug	85	8	of	of	IN
cord-306904-8iteddug	85	9	the	the	DT
cord-306904-8iteddug	85	10	stabilization	stabilization	NN
cord-306904-8iteddug	85	11	of	of	IN
cord-306904-8iteddug	85	12	human	human	JJ
cord-306904-8iteddug	85	13	plasminogen	plasminogen	NN
cord-306904-8iteddug	85	14	activator	activator	NN
cord-306904-8iteddug	85	15	inhibitor	inhibitor	NN
cord-306904-8iteddug	85	16	1	1	CD
cord-306904-8iteddug	85	17	(	(	-LRB-
cord-306904-8iteddug	85	18	PAI-1	PAI-1	NNP
cord-306904-8iteddug	85	19	,	,	,
cord-306904-8iteddug	85	20	also	also	RB
cord-306904-8iteddug	85	21	known	know	VBN
cord-306904-8iteddug	85	22	as	as	IN
cord-306904-8iteddug	85	23	serpin	serpin	NN
cord-306904-8iteddug	85	24	E1	E1	NNP
cord-306904-8iteddug	85	25	)	)	-RRB-
cord-306904-8iteddug	85	26	during	during	IN
cord-306904-8iteddug	85	27	the	the	DT
cord-306904-8iteddug	85	28	formation	formation	NN
cord-306904-8iteddug	85	29	of	of	IN
cord-306904-8iteddug	85	30	the	the	DT
cord-306904-8iteddug	85	31	transient	transient	JJ
cord-306904-8iteddug	85	32	ternary	ternary	JJ
cord-306904-8iteddug	85	33	"	"	``
cord-306904-8iteddug	85	34	molecular	molecular	JJ
cord-306904-8iteddug	85	35	sandwich	sandwich	NN
cord-306904-8iteddug	85	36	"	"	''
cord-306904-8iteddug	85	37	complex	complex	JJ
cord-306904-8iteddug	85	38	(	(	-LRB-
cord-306904-8iteddug	85	39	MSC	MSC	NNP
cord-306904-8iteddug	85	40	)	)	-RRB-
cord-306904-8iteddug	85	41	containing	contain	VBG
cord-306904-8iteddug	85	42	PAI-1	PAI-1	NNP
cord-306904-8iteddug	85	43	,	,	,
cord-306904-8iteddug	85	44	vitronectin	vitronectin	FW
cord-306904-8iteddug	85	45	(	(	-LRB-
cord-306904-8iteddug	85	46	Vn	Vn	NNP
cord-306904-8iteddug	85	47	)	)	-RRB-
cord-306904-8iteddug	85	48	,	,	,
cord-306904-8iteddug	85	49	and	and	CC
cord-306904-8iteddug	85	50	the	the	DT
cord-306904-8iteddug	85	51	target	target	NN
cord-306904-8iteddug	85	52	enzyme	enzyme	NN
cord-306904-8iteddug	85	53	.	.	.
cord-306904-8iteddug	86	1	17	17	CD
cord-306904-8iteddug	86	2	Major	Major	NNP
cord-306904-8iteddug	86	3	players	player	NNS
cord-306904-8iteddug	86	4	involved	involve	VBN
cord-306904-8iteddug	86	5	in	in	IN
cord-306904-8iteddug	86	6	the	the	DT
cord-306904-8iteddug	86	7	formation	formation	NN
cord-306904-8iteddug	86	8	of	of	IN
cord-306904-8iteddug	86	9	this	this	DT
cord-306904-8iteddug	86	10	complex	complex	NN
cord-306904-8iteddug	86	11	are	be	VBP
cord-306904-8iteddug	86	12	PAI-1	PAI-1	NNP
cord-306904-8iteddug	86	13	,	,	,
cord-306904-8iteddug	86	14	which	which	WDT
cord-306904-8iteddug	86	15	is	be	VBZ
cord-306904-8iteddug	86	16	a	a	DT
cord-306904-8iteddug	86	17	major	major	JJ
cord-306904-8iteddug	86	18	endogenous	endogenous	JJ
cord-306904-8iteddug	86	19	inhibitor	inhibitor	NN
cord-306904-8iteddug	86	20	of	of	IN
cord-306904-8iteddug	86	21	plasminogen	plasminogen	NN
cord-306904-8iteddug	86	22	activators	activator	NNS
cord-306904-8iteddug	86	23	,	,	,
cord-306904-8iteddug	86	24	a	a	DT
cord-306904-8iteddug	86	25	cell	cell	NN
cord-306904-8iteddug	86	26	adhesive	adhesive	NN
cord-306904-8iteddug	86	27	glycoprotein	glycoprotein	NN
cord-306904-8iteddug	86	28	Vn	Vn	NNP
cord-306904-8iteddug	86	29	,	,	,
cord-306904-8iteddug	86	30	and	and	CC
cord-306904-8iteddug	86	31	a	a	DT
cord-306904-8iteddug	86	32	proteinase	proteinase	NN
cord-306904-8iteddug	86	33	inhibited	inhibit	VBN
cord-306904-8iteddug	86	34	by	by	IN
cord-306904-8iteddug	86	35	PAI-1	PAI-1	NNP
cord-306904-8iteddug	86	36	.	.	.
cord-306904-8iteddug	87	1	An	an	DT
cord-306904-8iteddug	87	2	important	important	JJ
cord-306904-8iteddug	87	3	feature	feature	NN
cord-306904-8iteddug	87	4	of	of	IN
cord-306904-8iteddug	87	5	PAI-1	PAI-1	NNP
cord-306904-8iteddug	87	6	is	be	VBZ
cord-306904-8iteddug	87	7	its	-PRON-	PRP$
cord-306904-8iteddug	87	8	ability	ability	NN
cord-306904-8iteddug	87	9	to	to	TO
cord-306904-8iteddug	87	10	exist	exist	VB
cord-306904-8iteddug	87	11	in	in	IN
cord-306904-8iteddug	87	12	2	2	CD
cord-306904-8iteddug	87	13	forms	form	NNS
cord-306904-8iteddug	87	14	,	,	,
cord-306904-8iteddug	87	15	a	a	DT
cord-306904-8iteddug	87	16	metastable	metastable	JJ
cord-306904-8iteddug	87	17	active	active	JJ
cord-306904-8iteddug	87	18	conformation	conformation	NN
cord-306904-8iteddug	87	19	with	with	IN
cord-306904-8iteddug	87	20	solventaccessible	solventaccessible	JJ
cord-306904-8iteddug	87	21	reactive	reactive	JJ
cord-306904-8iteddug	87	22	center	center	NN
cord-306904-8iteddug	87	23	loop	loop	NN
cord-306904-8iteddug	87	24	(	(	-LRB-
cord-306904-8iteddug	87	25	RCL	RCL	NNP
cord-306904-8iteddug	87	26	)	)	-RRB-
cord-306904-8iteddug	87	27	and	and	CC
cord-306904-8iteddug	87	28	thermodynamically	thermodynamically	RB
cord-306904-8iteddug	87	29	stable	stable	JJ
cord-306904-8iteddug	87	30	,	,	,
cord-306904-8iteddug	87	31	inactive	inactive	JJ
cord-306904-8iteddug	87	32	,	,	,
cord-306904-8iteddug	87	33	latent	latent	JJ
cord-306904-8iteddug	87	34	conformation	conformation	NN
cord-306904-8iteddug	87	35	,	,	,
cord-306904-8iteddug	87	36	where	where	WRB
cord-306904-8iteddug	87	37	RCL	RCL	NNP
cord-306904-8iteddug	87	38	is	be	VBZ
cord-306904-8iteddug	87	39	spontaneously	spontaneously	RB
cord-306904-8iteddug	87	40	inserted	insert	VBN
cord-306904-8iteddug	87	41	to	to	IN
cord-306904-8iteddug	87	42	the	the	DT
cord-306904-8iteddug	87	43	middle	middle	NN
cord-306904-8iteddug	87	44	of	of	IN
cord-306904-8iteddug	87	45	the	the	DT
cord-306904-8iteddug	87	46	b	b	NN
cord-306904-8iteddug	87	47	-	-	HYPH
cord-306904-8iteddug	87	48	sheet	sheet	NN
cord-306904-8iteddug	87	49	B	b	NN
cord-306904-8iteddug	87	50	of	of	IN
cord-306904-8iteddug	87	51	PAI-1	PAI-1	NNP
cord-306904-8iteddug	87	52	.	.	.
cord-306904-8iteddug	88	1	17	17	CD
cord-306904-8iteddug	89	1	This	this	DT
cord-306904-8iteddug	89	2	"	"	``
cord-306904-8iteddug	89	3	magic	magic	JJ
cord-306904-8iteddug	89	4	"	"	''
cord-306904-8iteddug	89	5	chameleonlike	chameleonlike	JJ
cord-306904-8iteddug	89	6	RCL	RCL	NNP
cord-306904-8iteddug	89	7	is	be	VBZ
cord-306904-8iteddug	89	8	located	locate	VBN
cord-306904-8iteddug	89	9	in	in	IN
cord-306904-8iteddug	89	10	the	the	DT
cord-306904-8iteddug	89	11	331	331	CD
cord-306904-8iteddug	89	12	-	-	SYM
cord-306904-8iteddug	89	13	350	350	CD
cord-306904-8iteddug	89	14	region	region	NN
cord-306904-8iteddug	89	15	.	.	.
cord-306904-8iteddug	90	1	Figure	figure	NN
cord-306904-8iteddug	90	2	2A	2a	CD
cord-306904-8iteddug	90	3	shows	show	VBZ
cord-306904-8iteddug	90	4	that	that	IN
cord-306904-8iteddug	90	5	although	although	IN
cord-306904-8iteddug	90	6	human	human	JJ
cord-306904-8iteddug	90	7	PAI-1	PAI-1	NNP
cord-306904-8iteddug	90	8	(	(	-LRB-
cord-306904-8iteddug	90	9	UniProt	UniProt	NNP
cord-306904-8iteddug	90	10	ID	ID	NNP
cord-306904-8iteddug	90	11	:	:	:
cord-306904-8iteddug	90	12	P05121	P05121	NNP
cord-306904-8iteddug	90	13	)	)	-RRB-
cord-306904-8iteddug	90	14	is	be	VBZ
cord-306904-8iteddug	90	15	predicted	predict	VBN
cord-306904-8iteddug	90	16	to	to	TO
cord-306904-8iteddug	90	17	be	be	VB
cord-306904-8iteddug	90	18	mostly	mostly	RB
cord-306904-8iteddug	90	19	ordered	order	VBN
cord-306904-8iteddug	90	20	,	,	,
cord-306904-8iteddug	90	21	its	-PRON-	PRP$
cord-306904-8iteddug	90	22	RCL	RCL	NNP
cord-306904-8iteddug	90	23	is	be	VBZ
cord-306904-8iteddug	90	24	located	locate	VBN
cord-306904-8iteddug	90	25	within	within	IN
cord-306904-8iteddug	90	26	grayish	grayish	JJ
cord-306904-8iteddug	90	27	area	area	NN
cord-306904-8iteddug	90	28	with	with	IN
cord-306904-8iteddug	90	29	a	a	DT
cord-306904-8iteddug	90	30	mean	mean	JJ
cord-306904-8iteddug	90	31	disorder	disorder	NN
cord-306904-8iteddug	90	32	score	score	NN
cord-306904-8iteddug	90	33	close	close	RB
cord-306904-8iteddug	90	34	to	to	IN
cord-306904-8iteddug	90	35	0.5	0.5	CD
cord-306904-8iteddug	90	36	,	,	,
cord-306904-8iteddug	90	37	suggesting	suggest	VBG
cord-306904-8iteddug	90	38	that	that	IN
cord-306904-8iteddug	90	39	this	this	DT
cord-306904-8iteddug	90	40	region	region	NN
cord-306904-8iteddug	90	41	is	be	VBZ
cord-306904-8iteddug	90	42	characterized	characterize	VBN
cord-306904-8iteddug	90	43	by	by	IN
cord-306904-8iteddug	90	44	noticeable	noticeable	JJ
cord-306904-8iteddug	90	45	intrinsic	intrinsic	JJ
cord-306904-8iteddug	90	46	mobility	mobility	NN
cord-306904-8iteddug	90	47	.	.	.
cord-306904-8iteddug	91	1	Perumal	Perumal	NNP
cord-306904-8iteddug	91	2	et	et	FW
cord-306904-8iteddug	91	3	al	al	NNP
cord-306904-8iteddug	91	4	.	.	NNP
cord-306904-8iteddug	91	5	reported	report	VBD
cord-306904-8iteddug	91	6	that	that	IN
cord-306904-8iteddug	91	7	a	a	DT
cord-306904-8iteddug	91	8	specific	specific	JJ
cord-306904-8iteddug	91	9	interaction	interaction	NN
cord-306904-8iteddug	91	10	between	between	IN
cord-306904-8iteddug	91	11	the	the	DT
cord-306904-8iteddug	91	12	bacteriophage	bacteriophage	NN
cord-306904-8iteddug	91	13	T4	T4	NNP
cord-306904-8iteddug	91	14	UvsW	UvsW	NNP
cord-306904-8iteddug	91	15	helicase	helicase	NN
cord-306904-8iteddug	91	16	and	and	CC
cord-306904-8iteddug	91	17	the	the	DT
cord-306904-8iteddug	91	18	T4	T4	NNP
cord-306904-8iteddug	91	19	singlestranded	singlestranded	NNP
cord-306904-8iteddug	91	20	DNA	DNA	NNP
cord-306904-8iteddug	91	21	(	(	-LRB-
cord-306904-8iteddug	91	22	ssDNA	ssdna	NN
cord-306904-8iteddug	91	23	)	)	-RRB-
cord-306904-8iteddug	91	24	binding	bind	VBG
cord-306904-8iteddug	91	25	protein	protein	NN
cord-306904-8iteddug	91	26	gp32	gp32	NNP
cord-306904-8iteddug	91	27	is	be	VBZ
cord-306904-8iteddug	91	28	required	require	VBN
cord-306904-8iteddug	91	29	for	for	IN
cord-306904-8iteddug	91	30	enhancement	enhancement	NN
cord-306904-8iteddug	91	31	of	of	IN
cord-306904-8iteddug	91	32	the	the	DT
cord-306904-8iteddug	91	33	UvsW	UvsW	NNP
cord-306904-8iteddug	91	34	DNA	DNA	NNP
cord-306904-8iteddug	91	35	unwinding	unwinding	NN
cord-306904-8iteddug	91	36	function	function	NN
cord-306904-8iteddug	91	37	.	.	.
cord-306904-8iteddug	92	1	18	18	CD
cord-306904-8iteddug	93	1	Curiously	curiously	RB
cord-306904-8iteddug	93	2	,	,	,
cord-306904-8iteddug	93	3	UvsW	UvsW	NNP
cord-306904-8iteddug	93	4	interact	interact	VB
cord-306904-8iteddug	93	5	with	with	IN
cord-306904-8iteddug	93	6	gp32	gp32	NNP
cord-306904-8iteddug	93	7	,	,	,
cord-306904-8iteddug	93	8	both	both	CC
cord-306904-8iteddug	93	9	in	in	IN
cord-306904-8iteddug	93	10	the	the	DT
cord-306904-8iteddug	93	11	presence	presence	NN
cord-306904-8iteddug	93	12	and	and	CC
cord-306904-8iteddug	93	13	absence	absence	NN
cord-306904-8iteddug	93	14	of	of	IN
cord-306904-8iteddug	93	15	DNA	DNA	NNP
cord-306904-8iteddug	93	16	,	,	,
cord-306904-8iteddug	93	17	through	through	IN
cord-306904-8iteddug	93	18	the	the	DT
cord-306904-8iteddug	93	19	C	c	NN
cord-306904-8iteddug	93	20	-	-	HYPH
cord-306904-8iteddug	93	21	terminal	terminal	JJ
cord-306904-8iteddug	93	22	acidic	acidic	JJ
cord-306904-8iteddug	93	23	tail	tail	NN
cord-306904-8iteddug	93	24	of	of	IN
cord-306904-8iteddug	93	25	the	the	DT
cord-306904-8iteddug	93	26	gp32	gp32	NNP
cord-306904-8iteddug	93	27	protein	protein	NN
cord-306904-8iteddug	93	28	.	.	.
cord-306904-8iteddug	94	1	In	in	IN
cord-306904-8iteddug	94	2	the	the	DT
cord-306904-8iteddug	94	3	absence	absence	NN
cord-306904-8iteddug	94	4	of	of	IN
cord-306904-8iteddug	94	5	this	this	DT
cord-306904-8iteddug	94	6	interaction	interaction	NN
cord-306904-8iteddug	94	7	,	,	,
cord-306904-8iteddug	94	8	the	the	DT
cord-306904-8iteddug	94	9	ssDNA	ssdna	NN
cord-306904-8iteddug	94	10	annealing	anneal	VBG
cord-306904-8iteddug	94	11	and	and	CC
cord-306904-8iteddug	94	12	ATP	ATP	NNP
cord-306904-8iteddug	94	13	-	-	HYPH
cord-306904-8iteddug	94	14	dependent	dependent	JJ
cord-306904-8iteddug	94	15	translocation	translocation	NN
cord-306904-8iteddug	94	16	activities	activity	NNS
cord-306904-8iteddug	94	17	of	of	IN
cord-306904-8iteddug	94	18	UvsW	UvsW	NNP
cord-306904-8iteddug	94	19	are	be	VBP
cord-306904-8iteddug	94	20	severely	severely	RB
cord-306904-8iteddug	94	21	inhibited	inhibit	VBN
cord-306904-8iteddug	94	22	when	when	WRB
cord-306904-8iteddug	94	23	gp32	gp32	NNP
cord-306904-8iteddug	94	24	coats	coat	VBZ
cord-306904-8iteddug	94	25	the	the	DT
cord-306904-8iteddug	94	26	ssDNA	ssdna	JJ
cord-306904-8iteddug	94	27	lattice	lattice	NN
cord-306904-8iteddug	94	28	.	.	.
cord-306904-8iteddug	95	1	However	however	RB
cord-306904-8iteddug	95	2	,	,	,
cord-306904-8iteddug	95	3	when	when	WRB
cord-306904-8iteddug	95	4	UvsW	UvsW	NNP
cord-306904-8iteddug	95	5	and	and	CC
cord-306904-8iteddug	95	6	gp32	gp32	NNP
cord-306904-8iteddug	95	7	do	do	VBP
cord-306904-8iteddug	95	8	interact	interact	VB
cord-306904-8iteddug	95	9	,	,	,
cord-306904-8iteddug	95	10	UvsW	UvsW	NNP
cord-306904-8iteddug	95	11	is	be	VBZ
cord-306904-8iteddug	95	12	able	able	JJ
cord-306904-8iteddug	95	13	to	to	TO
cord-306904-8iteddug	95	14	efficiently	efficiently	RB
cord-306904-8iteddug	95	15	displace	displace	VB
cord-306904-8iteddug	95	16	the	the	DT
cord-306904-8iteddug	95	17	gp32	gp32	NNP
cord-306904-8iteddug	95	18	protein	protein	NN
cord-306904-8iteddug	95	19	from	from	IN
cord-306904-8iteddug	95	20	the	the	DT
cord-306904-8iteddug	95	21	ssDNA	ssdna	NN
cord-306904-8iteddug	95	22	.	.	.
cord-306904-8iteddug	96	1	The	the	DT
cord-306904-8iteddug	96	2	tail	tail	NN
cord-306904-8iteddug	96	3	-	-	HYPH
cord-306904-8iteddug	96	4	less	less	JJR
cord-306904-8iteddug	96	5	gp32	gp32	NNP
cord-306904-8iteddug	96	6	inhibits	inhibit	VBZ
cord-306904-8iteddug	96	7	activities	activity	NNS
cord-306904-8iteddug	96	8	of	of	IN
cord-306904-8iteddug	96	9	UvsW	UvsW	NNP
cord-306904-8iteddug	96	10	on	on	IN
cord-306904-8iteddug	96	11	DNA	DNA	NNP
cord-306904-8iteddug	96	12	in	in	IN
cord-306904-8iteddug	96	13	the	the	DT
cord-306904-8iteddug	96	14	presence	presence	NN
cord-306904-8iteddug	96	15	of	of	IN
cord-306904-8iteddug	96	16	gp32	gp32	NNP
cord-306904-8iteddug	96	17	.	.	.
cord-306904-8iteddug	97	1	18	18	CD
cord-306904-8iteddug	98	1	The	the	DT
cord-306904-8iteddug	98	2	UvsW	UvsW	NNP
cord-306904-8iteddug	98	3	helicase	helicase	NN
cord-306904-8iteddug	98	4	,	,	,
cord-306904-8iteddug	98	5	a	a	DT
cord-306904-8iteddug	98	6	member	member	NN
cord-306904-8iteddug	98	7	of	of	IN
cord-306904-8iteddug	98	8	the	the	DT
cord-306904-8iteddug	98	9	SF2	SF2	NNP
cord-306904-8iteddug	98	10	superfamily	superfamily	NN
cord-306904-8iteddug	98	11	of	of	IN
cord-306904-8iteddug	98	12	helicases	helicase	NNS
cord-306904-8iteddug	98	13	19	19	CD
cord-306904-8iteddug	98	14	(	(	-LRB-
cord-306904-8iteddug	98	15	i.e.	i.e.	FW
cord-306904-8iteddug	98	16	,	,	,
cord-306904-8iteddug	98	17	enzymes	enzyme	NNS
cord-306904-8iteddug	98	18	that	that	WDT
cord-306904-8iteddug	98	19	use	use	VBP
cord-306904-8iteddug	98	20	ATP	ATP	NNP
cord-306904-8iteddug	98	21	to	to	TO
cord-306904-8iteddug	98	22	carry	carry	VB
cord-306904-8iteddug	98	23	out	out	RP
cord-306904-8iteddug	98	24	mechanical	mechanical	JJ
cord-306904-8iteddug	98	25	work	work	NN
cord-306904-8iteddug	98	26	related	relate	VBN
cord-306904-8iteddug	98	27	to	to	IN
cord-306904-8iteddug	98	28	the	the	DT
cord-306904-8iteddug	98	29	unwinding	unwinding	NN
cord-306904-8iteddug	98	30	of	of	IN
cord-306904-8iteddug	98	31	duplex	duplex	JJ
cord-306904-8iteddug	98	32	DNA	dna	NN
cord-306904-8iteddug	98	33	structures	structure	NNS
cord-306904-8iteddug	98	34	and	and	CC
cord-306904-8iteddug	98	35	reorganization	reorganization	NN
cord-306904-8iteddug	98	36	of	of	IN
cord-306904-8iteddug	98	37	RNA	RNA	NNP
cord-306904-8iteddug	98	38	secondary	secondary	JJ
cord-306904-8iteddug	98	39	structures	structure	NNS
cord-306904-8iteddug	98	40	20	20	CD
cord-306904-8iteddug	98	41	)	)	-RRB-
cord-306904-8iteddug	98	42	,	,	,
cord-306904-8iteddug	98	43	is	be	VBZ
cord-306904-8iteddug	98	44	one	one	CD
cord-306904-8iteddug	98	45	of	of	IN
cord-306904-8iteddug	98	46	the	the	DT
cord-306904-8iteddug	98	47	3	3	CD
cord-306904-8iteddug	98	48	helicases	helicase	NNS
cord-306904-8iteddug	98	49	encoded	encode	VBN
cord-306904-8iteddug	98	50	by	by	IN
cord-306904-8iteddug	98	51	the	the	DT
cord-306904-8iteddug	98	52	bacteriophage	bacteriophage	NN
cord-306904-8iteddug	98	53	T4	T4	NNP
cord-306904-8iteddug	98	54	,	,	,
cord-306904-8iteddug	98	55	21	21	CD
cord-306904-8iteddug	98	56	where	where	WRB
cord-306904-8iteddug	98	57	it	-PRON-	PRP
cord-306904-8iteddug	98	58	plays	play	VBZ
cord-306904-8iteddug	98	59	a	a	DT
cord-306904-8iteddug	98	60	number	number	NN
cord-306904-8iteddug	98	61	of	of	IN
cord-306904-8iteddug	98	62	roles	role	NNS
cord-306904-8iteddug	98	63	in	in	IN
cord-306904-8iteddug	98	64	a	a	DT
cord-306904-8iteddug	98	65	variety	variety	NN
cord-306904-8iteddug	98	66	of	of	IN
cord-306904-8iteddug	98	67	DNA	dna	NN
cord-306904-8iteddug	98	68	repair	repair	NN
cord-306904-8iteddug	98	69	and	and	CC
cord-306904-8iteddug	98	70	recombination	recombination	NN
cord-306904-8iteddug	98	71	pathways	pathway	NNS
cord-306904-8iteddug	98	72	.	.	.
cord-306904-8iteddug	99	1	[	[	-LRB-
cord-306904-8iteddug	99	2	22	22	CD
cord-306904-8iteddug	99	3	]	]	-RRB-
cord-306904-8iteddug	99	4	[	[	-LRB-
cord-306904-8iteddug	99	5	23	23	CD
cord-306904-8iteddug	99	6	]	]	-RRB-
cord-306904-8iteddug	100	1	[	[	-LRB-
cord-306904-8iteddug	100	2	24	24	CD
cord-306904-8iteddug	100	3	]	]	-RRB-
cord-306904-8iteddug	100	4	[	[	-LRB-
cord-306904-8iteddug	100	5	25	25	CD
cord-306904-8iteddug	100	6	]	]	-RRB-
cord-306904-8iteddug	100	7	[	[	-LRB-
cord-306904-8iteddug	100	8	26	26	CD
cord-306904-8iteddug	100	9	]	]	-RRB-
cord-306904-8iteddug	100	10	[	[	-LRB-
cord-306904-8iteddug	100	11	27	27	CD
cord-306904-8iteddug	100	12	]	]	-RRB-
cord-306904-8iteddug	101	1	The	the	DT
cord-306904-8iteddug	101	2	involvement	involvement	NN
cord-306904-8iteddug	101	3	of	of	IN
cord-306904-8iteddug	101	4	this	this	DT
cord-306904-8iteddug	101	5	helicase	helicase	NN
cord-306904-8iteddug	101	6	in	in	IN
cord-306904-8iteddug	101	7	DNA	dna	NN
cord-306904-8iteddug	101	8	replication	replication	NN
cord-306904-8iteddug	101	9	is	be	VBZ
cord-306904-8iteddug	101	10	achieved	achieve	VBN
cord-306904-8iteddug	101	11	via	via	IN
cord-306904-8iteddug	101	12	the	the	DT
cord-306904-8iteddug	101	13	UvsW	UvsW	NNP
cord-306904-8iteddug	101	14	-	-	HYPH
cord-306904-8iteddug	101	15	mediated	mediate	VBN
cord-306904-8iteddug	101	16	unwinding	unwinding	NN
cord-306904-8iteddug	101	17	of	of	IN
cord-306904-8iteddug	101	18	R	r	NN
cord-306904-8iteddug	101	19	-	-	HYPH
cord-306904-8iteddug	101	20	loop	loop	NN
cord-306904-8iteddug	101	21	structures	structure	NNS
cord-306904-8iteddug	101	22	generated	generate	VBN
cord-306904-8iteddug	101	23	at	at	IN
cord-306904-8iteddug	101	24	the	the	DT
cord-306904-8iteddug	101	25	replication	replication	NN
cord-306904-8iteddug	101	26	origin	origin	NN
cord-306904-8iteddug	101	27	by	by	IN
cord-306904-8iteddug	101	28	the	the	DT
cord-306904-8iteddug	101	29	host	host	NN
cord-306904-8iteddug	101	30	RNA	rna	NN
cord-306904-8iteddug	101	31	polymerase	polymerase	NN
cord-306904-8iteddug	101	32	.	.	.
cord-306904-8iteddug	102	1	22	22	CD
cord-306904-8iteddug	102	2	UvsW	UvsW	NNP
cord-306904-8iteddug	102	3	(	(	-LRB-
cord-306904-8iteddug	102	4	UniProt	UniProt	NNP
cord-306904-8iteddug	102	5	ID	ID	NNP
cord-306904-8iteddug	102	6	:	:	:
cord-306904-8iteddug	103	1	P20703	p20703	NN
cord-306904-8iteddug	103	2	)	)	-RRB-
cord-306904-8iteddug	103	3	activity	activity	NN
cord-306904-8iteddug	103	4	involves	involve	VBZ
cord-306904-8iteddug	103	5	the	the	DT
cord-306904-8iteddug	103	6	generation	generation	NN
cord-306904-8iteddug	103	7	and	and	CC
cord-306904-8iteddug	103	8	consumption	consumption	NN
cord-306904-8iteddug	103	9	of	of	IN
cord-306904-8iteddug	103	10	single	single	JJ
cord-306904-8iteddug	103	11	stranded	strand	VBN
cord-306904-8iteddug	103	12	DNA	dna	NN
cord-306904-8iteddug	103	13	(	(	-LRB-
cord-306904-8iteddug	103	14	ssDNA	ssdna	NN
cord-306904-8iteddug	103	15	)	)	-RRB-
cord-306904-8iteddug	103	16	.	.	.
cord-306904-8iteddug	104	1	In	in	IN
cord-306904-8iteddug	104	2	agreement	agreement	NN
cord-306904-8iteddug	104	3	with	with	IN
cord-306904-8iteddug	104	4	the	the	DT
cord-306904-8iteddug	104	5	overall	overall	JJ
cord-306904-8iteddug	104	6	low	low	JJ
cord-306904-8iteddug	104	7	disorder	disorder	NN
cord-306904-8iteddug	104	8	predisposition	predisposition	NN
cord-306904-8iteddug	104	9	(	(	-LRB-
cord-306904-8iteddug	104	10	see	see	VB
cord-306904-8iteddug	104	11	Fig	Fig	NNP
cord-306904-8iteddug	104	12	.	.	.
cord-306904-8iteddug	104	13	3A	3A	NNP
cord-306904-8iteddug	104	14	)	)	-RRB-
cord-306904-8iteddug	104	15	,	,	,
cord-306904-8iteddug	104	16	almost	almost	RB
cord-306904-8iteddug	104	17	entire	entire	JJ
cord-306904-8iteddug	104	18	sequence	sequence	NN
cord-306904-8iteddug	104	19	of	of	IN
cord-306904-8iteddug	104	20	UvsW	UvsW	NNP
cord-306904-8iteddug	104	21	was	be	VBD
cord-306904-8iteddug	104	22	successfully	successfully	RB
cord-306904-8iteddug	104	23	crystallized	crystallize	VBN
cord-306904-8iteddug	105	1	(	(	-LRB-
cord-306904-8iteddug	105	2	Fig	Fig	NNP
cord-306904-8iteddug	105	3	.	.	.
cord-306904-8iteddug	105	4	3B	3B	NNP
cord-306904-8iteddug	105	5	,	,	,
cord-306904-8iteddug	105	6	PDB	PDB	NNP
cord-306904-8iteddug	105	7	ID	ID	NNP
cord-306904-8iteddug	105	8	:	:	:
cord-306904-8iteddug	105	9	2OCA	2OCA	NNP
cord-306904-8iteddug	105	10	)	)	-RRB-
cord-306904-8iteddug	105	11	.	.	.
cord-306904-8iteddug	106	1	Naked	naked	JJ
cord-306904-8iteddug	106	2	ssDNA	ssdna	RB
cord-306904-8iteddug	106	3	rarely	rarely	RB
cord-306904-8iteddug	106	4	occurs	occur	VBZ
cord-306904-8iteddug	106	5	within	within	IN
cord-306904-8iteddug	106	6	T4infected	t4infected	JJ
cord-306904-8iteddug	106	7	cells	cell	NNS
cord-306904-8iteddug	106	8	as	as	IN
cord-306904-8iteddug	106	9	they	-PRON-	PRP
cord-306904-8iteddug	106	10	are	be	VBP
cord-306904-8iteddug	106	11	immediately	immediately	RB
cord-306904-8iteddug	106	12	coated	coat	VBN
cord-306904-8iteddug	106	13	with	with	IN
cord-306904-8iteddug	106	14	gp32	gp32	NNP
cord-306904-8iteddug	106	15	ssDNA	ssdna	NN
cord-306904-8iteddug	106	16	binding	bind	VBG
cord-306904-8iteddug	106	17	protein	protein	NN
cord-306904-8iteddug	106	18	,	,	,
cord-306904-8iteddug	106	19	which	which	WDT
cord-306904-8iteddug	106	20	serves	serve	VBZ
cord-306904-8iteddug	106	21	to	to	TO
cord-306904-8iteddug	106	22	protect	protect	VB
cord-306904-8iteddug	106	23	it	-PRON-	PRP
cord-306904-8iteddug	106	24	against	against	IN
cord-306904-8iteddug	106	25	degradation	degradation	NN
cord-306904-8iteddug	106	26	by	by	IN
cord-306904-8iteddug	106	27	endonucleases	endonuclease	NNS
cord-306904-8iteddug	106	28	.	.	.
cord-306904-8iteddug	107	1	The	the	DT
cord-306904-8iteddug	107	2	gp32	gp32	NN
cord-306904-8iteddug	107	3	is	be	VBZ
cord-306904-8iteddug	107	4	also	also	RB
cord-306904-8iteddug	107	5	thought	think	VBN
cord-306904-8iteddug	107	6	to	to	TO
cord-306904-8iteddug	107	7	coordinate	coordinate	VB
cord-306904-8iteddug	107	8	the	the	DT
cord-306904-8iteddug	107	9	many	many	JJ
cord-306904-8iteddug	107	10	activities	activity	NNS
cord-306904-8iteddug	107	11	necessary	necessary	JJ
cord-306904-8iteddug	107	12	to	to	TO
cord-306904-8iteddug	107	13	carry	carry	VB
cord-306904-8iteddug	107	14	out	out	RP
cord-306904-8iteddug	107	15	DNA	dna	NN
cord-306904-8iteddug	107	16	replication	replication	NN
cord-306904-8iteddug	107	17	,	,	,
cord-306904-8iteddug	107	18	recombination	recombination	NN
cord-306904-8iteddug	107	19	and	and	CC
cord-306904-8iteddug	107	20	repair	repair	NN
cord-306904-8iteddug	107	21	by	by	IN
cord-306904-8iteddug	107	22	recruiting	recruit	VBG
cord-306904-8iteddug	107	23	and	and	CC
cord-306904-8iteddug	107	24	modulating	modulate	VBG
cord-306904-8iteddug	107	25	the	the	DT
cord-306904-8iteddug	107	26	activity	activity	NN
cord-306904-8iteddug	107	27	of	of	IN
cord-306904-8iteddug	107	28	the	the	DT
cord-306904-8iteddug	107	29	enzymes	enzyme	NNS
cord-306904-8iteddug	107	30	involved	involve	VBN
cord-306904-8iteddug	107	31	in	in	IN
cord-306904-8iteddug	107	32	these	these	DT
cord-306904-8iteddug	107	33	processes	process	NNS
cord-306904-8iteddug	107	34	.	.	.
cord-306904-8iteddug	108	1	28	28	CD
cord-306904-8iteddug	109	1	The	the	DT
cord-306904-8iteddug	109	2	bacteriophage	bacteriophage	NN
cord-306904-8iteddug	109	3	T4	T4	NNP
cord-306904-8iteddug	109	4	gp32	gp32	NNP
cord-306904-8iteddug	109	5	(	(	-LRB-
cord-306904-8iteddug	109	6	UniProt	UniProt	NNP
cord-306904-8iteddug	109	7	ID	ID	NNP
cord-306904-8iteddug	109	8	:	:	:
cord-306904-8iteddug	109	9	P03695	P03695	NNP
cord-306904-8iteddug	109	10	)	)	-RRB-
cord-306904-8iteddug	109	11	is	be	VBZ
cord-306904-8iteddug	109	12	a	a	DT
cord-306904-8iteddug	109	13	301	301	CD
cord-306904-8iteddug	109	14	residue	residue	NN
cord-306904-8iteddug	109	15	-	-	HYPH
cord-306904-8iteddug	109	16	long	long	JJ
cord-306904-8iteddug	109	17	protein	protein	NN
cord-306904-8iteddug	109	18	.	.	.
cord-306904-8iteddug	110	1	The	the	DT
cord-306904-8iteddug	110	2	crystal	crystal	JJ
cord-306904-8iteddug	110	3	structure	structure	NN
cord-306904-8iteddug	110	4	of	of	IN
cord-306904-8iteddug	110	5	the	the	DT
cord-306904-8iteddug	110	6	gp32	gp32	NNP
cord-306904-8iteddug	110	7	central	central	JJ
cord-306904-8iteddug	110	8	region	region	NN
cord-306904-8iteddug	110	9	(	(	-LRB-
cord-306904-8iteddug	110	10	residues	residue	NNS
cord-306904-8iteddug	110	11	22	22	CD
cord-306904-8iteddug	110	12	-	-	SYM
cord-306904-8iteddug	110	13	239	239	CD
cord-306904-8iteddug	110	14	)	)	-RRB-
cord-306904-8iteddug	110	15	is	be	VBZ
cord-306904-8iteddug	110	16	known	know	VBN
cord-306904-8iteddug	110	17	(	(	-LRB-
cord-306904-8iteddug	110	18	see	see	VB
cord-306904-8iteddug	110	19	Fig	Fig	NNP
cord-306904-8iteddug	110	20	.	.	.
cord-306904-8iteddug	110	21	3C	3C	NNP
cord-306904-8iteddug	110	22	)	)	-RRB-
cord-306904-8iteddug	110	23	.	.	.
cord-306904-8iteddug	111	1	29	29	CD
cord-306904-8iteddug	111	2	Gp32	gp32	NN
cord-306904-8iteddug	111	3	binds	bind	VBZ
cord-306904-8iteddug	111	4	preferentially	preferentially	RB
cord-306904-8iteddug	111	5	to	to	TO
cord-306904-8iteddug	111	6	ssDNA	ssdna	VB
cord-306904-8iteddug	111	7	and	and	CC
cord-306904-8iteddug	111	8	destabilizes	destabilize	VBZ
cord-306904-8iteddug	111	9	double	double	RB
cord-306904-8iteddug	111	10	-	-	HYPH
cord-306904-8iteddug	111	11	stranded	strand	VBN
cord-306904-8iteddug	111	12	DNA	dna	NN
cord-306904-8iteddug	111	13	.	.	.
cord-306904-8iteddug	112	1	It	-PRON-	PRP
cord-306904-8iteddug	112	2	is	be	VBZ
cord-306904-8iteddug	112	3	involved	involve	VBN
cord-306904-8iteddug	112	4	in	in	IN
cord-306904-8iteddug	112	5	DNA	dna	NN
cord-306904-8iteddug	112	6	replication	replication	NN
cord-306904-8iteddug	112	7	,	,	,
cord-306904-8iteddug	112	8	repair	repair	NN
cord-306904-8iteddug	112	9	and	and	CC
cord-306904-8iteddug	112	10	recombination	recombination	NN
cord-306904-8iteddug	112	11	,	,	,
cord-306904-8iteddug	112	12	dinds	dind	NNS
cord-306904-8iteddug	112	13	ssDNA	ssdna	RB
cord-306904-8iteddug	112	14	as	as	IN
cord-306904-8iteddug	112	15	the	the	DT
cord-306904-8iteddug	112	16	replication	replication	NN
cord-306904-8iteddug	112	17	fork	fork	NN
cord-306904-8iteddug	112	18	advances	advance	NNS
cord-306904-8iteddug	112	19	and	and	CC
cord-306904-8iteddug	112	20	stimulates	stimulate	VBZ
cord-306904-8iteddug	112	21	the	the	DT
cord-306904-8iteddug	112	22	replisome	replisome	NNP
cord-306904-8iteddug	112	23	processivity	processivity	NN
cord-306904-8iteddug	112	24	and	and	CC
cord-306904-8iteddug	112	25	accuracy	accuracy	NN
cord-306904-8iteddug	112	26	.	.	.
cord-306904-8iteddug	113	1	The	the	DT
cord-306904-8iteddug	113	2	N	n	CD
cord-306904-8iteddug	113	3	-	-	HYPH
cord-306904-8iteddug	113	4	terminal	terminal	JJ
cord-306904-8iteddug	113	5	region	region	NN
cord-306904-8iteddug	113	6	of	of	IN
cord-306904-8iteddug	113	7	gp32	gp32	NNP
cord-306904-8iteddug	113	8	is	be	VBZ
cord-306904-8iteddug	113	9	important	important	JJ
cord-306904-8iteddug	113	10	for	for	IN
cord-306904-8iteddug	113	11	the	the	DT
cord-306904-8iteddug	113	12	cooperative	cooperative	JJ
cord-306904-8iteddug	113	13	binding	binding	NN
cord-306904-8iteddug	113	14	of	of	IN
cord-306904-8iteddug	113	15	gp32	gp32	NNP
cord-306904-8iteddug	113	16	monomers	monomer	NNS
cord-306904-8iteddug	113	17	on	on	IN
cord-306904-8iteddug	113	18	ssDNA	ssdna	NN
cord-306904-8iteddug	113	19	,	,	,
cord-306904-8iteddug	113	20	whereas	whereas	IN
cord-306904-8iteddug	113	21	the	the	DT
cord-306904-8iteddug	113	22	C	c	NN
cord-306904-8iteddug	113	23	-	-	HYPH
cord-306904-8iteddug	113	24	terminal	terminal	JJ
cord-306904-8iteddug	113	25	acidic	acidic	JJ
cord-306904-8iteddug	113	26	tail	tail	NN
cord-306904-8iteddug	113	27	is	be	VBZ
cord-306904-8iteddug	113	28	involved	involve	VBN
cord-306904-8iteddug	113	29	interaction	interaction	NN
cord-306904-8iteddug	113	30	with	with	IN
cord-306904-8iteddug	113	31	the	the	DT
cord-306904-8iteddug	113	32	replicative	replicative	JJ
cord-306904-8iteddug	113	33	DNA	dna	NN
cord-306904-8iteddug	113	34	polymerase	polymerase	NN
cord-306904-8iteddug	113	35	,	,	.
cord-306904-8iteddug	114	1	the	the	DT
cord-306904-8iteddug	114	2	primase	primase	NN
cord-306904-8iteddug	114	3	and	and	CC
cord-306904-8iteddug	114	4	helicase	helicase	NN
cord-306904-8iteddug	114	5	loader	loader	NN
cord-306904-8iteddug	114	6	protein	protein	NN
cord-306904-8iteddug	114	7	.	.	.
cord-306904-8iteddug	115	1	[	[	-LRB-
cord-306904-8iteddug	115	2	30	30	CD
cord-306904-8iteddug	115	3	]	]	-RRB-
cord-306904-8iteddug	115	4	[	[	-LRB-
cord-306904-8iteddug	115	5	31	31	CD
cord-306904-8iteddug	115	6	]	]	-RRB-
cord-306904-8iteddug	115	7	[	[	-LRB-
cord-306904-8iteddug	115	8	32	32	CD
cord-306904-8iteddug	115	9	]	]	-RRB-
cord-306904-8iteddug	116	1	Also	also	RB
cord-306904-8iteddug	116	2	,	,	,
cord-306904-8iteddug	116	3	this	this	DT
cord-306904-8iteddug	116	4	C	c	NN
cord-306904-8iteddug	116	5	-	-	HYPH
cord-306904-8iteddug	116	6	terminal	terminal	NN
cord-306904-8iteddug	116	7	region	region	NN
cord-306904-8iteddug	116	8	(	(	-LRB-
cord-306904-8iteddug	116	9	residues	residue	NNS
cord-306904-8iteddug	116	10	254	254	CD
cord-306904-8iteddug	116	11	-	-	HYPH
cord-306904-8iteddug	116	12	301	301	CD
cord-306904-8iteddug	116	13	)	)	-RRB-
cord-306904-8iteddug	116	14	was	be	VBD
cord-306904-8iteddug	116	15	shown	show	VBN
cord-306904-8iteddug	116	16	to	to	TO
cord-306904-8iteddug	116	17	play	play	VB
cord-306904-8iteddug	116	18	a	a	DT
cord-306904-8iteddug	116	19	crucial	crucial	JJ
cord-306904-8iteddug	116	20	role	role	NN
cord-306904-8iteddug	116	21	in	in	IN
cord-306904-8iteddug	116	22	controlling	control	VBG
cord-306904-8iteddug	116	23	the	the	DT
cord-306904-8iteddug	116	24	D	d	NN
cord-306904-8iteddug	116	25	-	-	HYPH
cord-306904-8iteddug	116	26	loop	loop	NN
cord-306904-8iteddug	116	27	unwinding	unwinding	NN
cord-306904-8iteddug	116	28	capability	capability	NN
cord-306904-8iteddug	116	29	of	of	IN
cord-306904-8iteddug	116	30	UvsW	UvsW	NNP
cord-306904-8iteddug	116	31	,	,	,
cord-306904-8iteddug	116	32	since	since	IN
cord-306904-8iteddug	116	33	the	the	DT
cord-306904-8iteddug	116	34	presence	presence	NN
cord-306904-8iteddug	116	35	of	of	IN
cord-306904-8iteddug	116	36	a	a	DT
cord-306904-8iteddug	116	37	mutant	mutant	JJ
cord-306904-8iteddug	116	38	gp32	gp32	NNP
cord-306904-8iteddug	116	39	protein	protein	NN
cord-306904-8iteddug	116	40	lacking	lack	VBG
cord-306904-8iteddug	116	41	the	the	DT
cord-306904-8iteddug	116	42	acidic	acidic	JJ
cord-306904-8iteddug	116	43	tail	tail	NN
cord-306904-8iteddug	116	44	(	(	-LRB-
cord-306904-8iteddug	116	45	delta254	delta254	NNP
cord-306904-8iteddug	116	46	-	-	HYPH
cord-306904-8iteddug	116	47	301	301	CD
cord-306904-8iteddug	116	48	,	,	,
cord-306904-8iteddug	116	49	gp32-A	gp32-A	NNP
cord-306904-8iteddug	116	50	)	)	-RRB-
cord-306904-8iteddug	116	51	led	lead	VBD
cord-306904-8iteddug	116	52	to	to	IN
cord-306904-8iteddug	116	53	a	a	DT
cord-306904-8iteddug	116	54	significant	significant	JJ
cord-306904-8iteddug	116	55	reduction	reduction	NN
cord-306904-8iteddug	116	56	in	in	IN
cord-306904-8iteddug	116	57	the	the	DT
cord-306904-8iteddug	116	58	unwinding	unwinding	NN
cord-306904-8iteddug	116	59	of	of	IN
cord-306904-8iteddug	116	60	the	the	DT
cord-306904-8iteddug	116	61	D	d	NN
cord-306904-8iteddug	116	62	-	-	HYPH
cord-306904-8iteddug	116	63	loop	loop	NN
cord-306904-8iteddug	116	64	substrate	substrate	NN
cord-306904-8iteddug	116	65	.	.	.
cord-306904-8iteddug	117	1	18	18	CD
cord-306904-8iteddug	118	1	Fig	Fig	NNP
cord-306904-8iteddug	118	2	.	.	.
cord-306904-8iteddug	118	3	3D	3D	NNP
cord-306904-8iteddug	118	4	shows	show	VBZ
cord-306904-8iteddug	118	5	that	that	IN
cord-306904-8iteddug	118	6	a	a	DT
cord-306904-8iteddug	118	7	significant	significant	JJ
cord-306904-8iteddug	118	8	portion	portion	NN
cord-306904-8iteddug	118	9	of	of	IN
cord-306904-8iteddug	118	10	the	the	DT
cord-306904-8iteddug	118	11	C	C	NNP
cord-306904-8iteddug	118	12	-	-	HYPH
cord-306904-8iteddug	118	13	terminal	terminal	NN
cord-306904-8iteddug	118	14	half	half	NN
cord-306904-8iteddug	118	15	of	of	IN
cord-306904-8iteddug	118	16	this	this	DT
cord-306904-8iteddug	118	17	protein	protein	NN
cord-306904-8iteddug	118	18	is	be	VBZ
cord-306904-8iteddug	118	19	predicted	predict	VBN
cord-306904-8iteddug	118	20	to	to	TO
cord-306904-8iteddug	118	21	be	be	VB
cord-306904-8iteddug	118	22	mostly	mostly	RB
cord-306904-8iteddug	118	23	disordered	disordered	JJ
cord-306904-8iteddug	118	24	(	(	-LRB-
cord-306904-8iteddug	118	25	residues	residue	NNS
cord-306904-8iteddug	118	26	200	200	CD
cord-306904-8iteddug	118	27	-	-	HYPH
cord-306904-8iteddug	118	28	301	301	CD
cord-306904-8iteddug	118	29	)	)	-RRB-
cord-306904-8iteddug	118	30	.	.	.
cord-306904-8iteddug	119	1	Curiously	curiously	RB
cord-306904-8iteddug	119	2	,	,	,
cord-306904-8iteddug	119	3	this	this	DT
cord-306904-8iteddug	119	4	disordered	disordered	JJ
cord-306904-8iteddug	119	5	region	region	NN
cord-306904-8iteddug	119	6	includes	include	VBZ
cord-306904-8iteddug	119	7	the	the	DT
cord-306904-8iteddug	119	8	functionally	functionally	RB
cord-306904-8iteddug	119	9	important	important	JJ
cord-306904-8iteddug	119	10	C	c	NN
cord-306904-8iteddug	119	11	-	-	HYPH
cord-306904-8iteddug	119	12	terminal	terminal	NN
cord-306904-8iteddug	119	13	tail	tail	NN
cord-306904-8iteddug	119	14	that	that	WDT
cord-306904-8iteddug	119	15	defines	define	VBZ
cord-306904-8iteddug	119	16	the	the	DT
cord-306904-8iteddug	119	17	ability	ability	NN
cord-306904-8iteddug	119	18	of	of	IN
cord-306904-8iteddug	119	19	gp32	gp32	NN
cord-306904-8iteddug	119	20	to	to	TO
cord-306904-8iteddug	119	21	modulate	modulate	VB
cord-306904-8iteddug	119	22	the	the	DT
cord-306904-8iteddug	119	23	UvsW	UvsW	NNP
cord-306904-8iteddug	119	24	activity	activity	NN
cord-306904-8iteddug	119	25	.	.	.
cord-306904-8iteddug	120	1	PilF	PilF	NNP
cord-306904-8iteddug	120	2	and	and	CC
cord-306904-8iteddug	120	3	PilQ	PilQ	NNP
cord-306904-8iteddug	120	4	of	of	IN
cord-306904-8iteddug	120	5	the	the	DT
cord-306904-8iteddug	120	6	Pseudomonas	Pseudomonas	NNP
cord-306904-8iteddug	120	7	aeruginosa	aeruginosa	NN
cord-306904-8iteddug	120	8	Type	Type	NNP
cord-306904-8iteddug	120	9	IV	IV	NNP
cord-306904-8iteddug	120	10	pilus	pilus	NN
cord-306904-8iteddug	120	11	system	system	NN
cord-306904-8iteddug	121	1	Some	some	DT
cord-306904-8iteddug	121	2	bacteria	bacteria	NNS
cord-306904-8iteddug	121	3	and	and	CC
cord-306904-8iteddug	121	4	archaea	archaea	NNS
cord-306904-8iteddug	121	5	contain	contain	VBP
cord-306904-8iteddug	121	6	specific	specific	JJ
cord-306904-8iteddug	121	7	cell	cell	NN
cord-306904-8iteddug	121	8	envelope	envelope	NN
cord-306904-8iteddug	121	9	-	-	HYPH
cord-306904-8iteddug	121	10	spanning	span	VBG
cord-306904-8iteddug	121	11	biomolecular	biomolecular	JJ
cord-306904-8iteddug	121	12	machines	machine	NNS
cord-306904-8iteddug	121	13	,	,	,
cord-306904-8iteddug	121	14	Type	Type	NNP
cord-306904-8iteddug	121	15	IV	IV	NNP
cord-306904-8iteddug	121	16	pili	pili	NNP
cord-306904-8iteddug	121	17	(	(	-LRB-
cord-306904-8iteddug	121	18	T4P	T4P	NNP
cord-306904-8iteddug	121	19	)	)	-RRB-
cord-306904-8iteddug	121	20	,	,	,
cord-306904-8iteddug	121	21	which	which	WDT
cord-306904-8iteddug	121	22	are	be	VBP
cord-306904-8iteddug	121	23	used	use	VBN
cord-306904-8iteddug	121	24	by	by	IN
cord-306904-8iteddug	121	25	bacteria	bacteria	NNS
cord-306904-8iteddug	121	26	and	and	CC
cord-306904-8iteddug	121	27	archaea	archaea	NNS
cord-306904-8iteddug	121	28	to	to	TO
cord-306904-8iteddug	121	29	interact	interact	VB
cord-306904-8iteddug	121	30	with	with	IN
cord-306904-8iteddug	121	31	the	the	DT
cord-306904-8iteddug	121	32	environment	environment	NN
cord-306904-8iteddug	121	33	.	.	.
cord-306904-8iteddug	122	1	Pilus	pilus	JJ
cord-306904-8iteddug	122	2	biogenesis	biogenesis	NN
cord-306904-8iteddug	122	3	is	be	VBZ
cord-306904-8iteddug	122	4	controlled	control	VBN
cord-306904-8iteddug	122	5	by	by	IN
cord-306904-8iteddug	122	6	the	the	DT
cord-306904-8iteddug	122	7	assembly	assembly	NN
cord-306904-8iteddug	122	8	of	of	IN
cord-306904-8iteddug	122	9	the	the	DT
cord-306904-8iteddug	122	10	outer	outer	JJ
cord-306904-8iteddug	122	11	membrane	membrane	NN
cord-306904-8iteddug	122	12	PilQ	PilQ	NNP
cord-306904-8iteddug	122	13	secretin	secretin	NNS
cord-306904-8iteddug	122	14	channel	channel	NN
cord-306904-8iteddug	122	15	through	through	IN
cord-306904-8iteddug	122	16	which	which	WDT
cord-306904-8iteddug	122	17	the	the	DT
cord-306904-8iteddug	122	18	pili	pili	NNP
cord-306904-8iteddug	122	19	are	be	VBP
cord-306904-8iteddug	122	20	extruded	extrude	VBN
cord-306904-8iteddug	122	21	.	.	.
cord-306904-8iteddug	123	1	Koo	Koo	NNP
cord-306904-8iteddug	123	2	et	et	FW
cord-306904-8iteddug	123	3	al	al	NNP
cord-306904-8iteddug	123	4	.	.	NNP
cord-306904-8iteddug	123	5	investigated	investigate	VBD
cord-306904-8iteddug	123	6	the	the	DT
cord-306904-8iteddug	123	7	roles	role	NNS
cord-306904-8iteddug	123	8	of	of	IN
cord-306904-8iteddug	123	9	the	the	DT
cord-306904-8iteddug	123	10	Pseudomonas	Pseudomonas	NNP
cord-306904-8iteddug	123	11	aeruginosa	aeruginosa	NN
cord-306904-8iteddug	123	12	type	type	NN
cord-306904-8iteddug	123	13	IV	IV	NNP
cord-306904-8iteddug	123	14	pili	pili	NNP
cord-306904-8iteddug	123	15	(	(	-LRB-
cord-306904-8iteddug	123	16	T4P	T4P	NNP
cord-306904-8iteddug	123	17	)	)	-RRB-
cord-306904-8iteddug	123	18	pilotin	pilotin	NN
cord-306904-8iteddug	123	19	protein	protein	NN
cord-306904-8iteddug	123	20	PilF	PilF	NNP
cord-306904-8iteddug	123	21	in	in	IN
cord-306904-8iteddug	123	22	the	the	DT
cord-306904-8iteddug	123	23	outer	outer	JJ
cord-306904-8iteddug	123	24	membrane	membrane	NN
cord-306904-8iteddug	124	1	PilQ	PilQ	NNP
cord-306904-8iteddug	124	2	secretin	secretin	NNP
cord-306904-8iteddug	124	3	channel	channel	NN
cord-306904-8iteddug	124	4	targeting	targeting	NN
cord-306904-8iteddug	124	5	,	,	,
cord-306904-8iteddug	124	6	oligomerization	oligomerization	NN
cord-306904-8iteddug	124	7	,	,	,
cord-306904-8iteddug	124	8	and	and	CC
cord-306904-8iteddug	124	9	function	function	NN
cord-306904-8iteddug	124	10	.	.	.
cord-306904-8iteddug	125	1	33	33	CD
cord-306904-8iteddug	125	2	PilF	PilF	NNP
cord-306904-8iteddug	125	3	belongs	belong	VBZ
cord-306904-8iteddug	125	4	to	to	IN
cord-306904-8iteddug	125	5	the	the	DT
cord-306904-8iteddug	125	6	class	class	NN
cord-306904-8iteddug	125	7	1	1	CD
cord-306904-8iteddug	125	8	pilotins	pilotin	NNS
cord-306904-8iteddug	125	9	,	,	,
cord-306904-8iteddug	125	10	which	which	WDT
cord-306904-8iteddug	125	11	are	be	VBP
cord-306904-8iteddug	125	12	a	a	DT
cord-306904-8iteddug	125	13	-	-	HYPH
cord-306904-8iteddug	125	14	helical	helical	JJ
cord-306904-8iteddug	125	15	proteins	protein	NNS
cord-306904-8iteddug	125	16	containing	contain	VBG
cord-306904-8iteddug	125	17	several	several	JJ
cord-306904-8iteddug	125	18	tetratricopeptide	tetratricopeptide	NN
cord-306904-8iteddug	125	19	(	(	-LRB-
cord-306904-8iteddug	125	20	TPR	TPR	NNP
cord-306904-8iteddug	125	21	)	)	-RRB-
cord-306904-8iteddug	125	22	motifs	motif	NNS
cord-306904-8iteddug	125	23	,	,	,
cord-306904-8iteddug	125	24	that	that	WDT
cord-306904-8iteddug	125	25	are	be	VBP
cord-306904-8iteddug	125	26	comprised	comprise	VBN
cord-306904-8iteddug	125	27	of	of	IN
cord-306904-8iteddug	125	28	approximately	approximately	RB
cord-306904-8iteddug	125	29	34amino	34amino	CD
cord-306904-8iteddug	125	30	acid	acid	NN
cord-306904-8iteddug	125	31	and	and	CC
cord-306904-8iteddug	125	32	are	be	VBP
cord-306904-8iteddug	125	33	able	able	JJ
cord-306904-8iteddug	125	34	to	to	TO
cord-306904-8iteddug	125	35	form	form	VB
cord-306904-8iteddug	125	36	a	a	DT
cord-306904-8iteddug	125	37	superhelical	superhelical	JJ
cord-306904-8iteddug	125	38	fold	fold	NN
cord-306904-8iteddug	125	39	that	that	WDT
cord-306904-8iteddug	125	40	mediates	mediate	VBZ
cord-306904-8iteddug	125	41	proteinprotein	proteinprotein	NNP
cord-306904-8iteddug	125	42	interactions	interaction	NNS
cord-306904-8iteddug	125	43	in	in	IN
cord-306904-8iteddug	125	44	both	both	DT
cord-306904-8iteddug	125	45	prokaryotes	prokaryote	NNS
cord-306904-8iteddug	125	46	and	and	CC
cord-306904-8iteddug	125	47	eukaryotes	eukaryote	NNS
cord-306904-8iteddug	125	48	.	.	.
cord-306904-8iteddug	126	1	33	33	CD
cord-306904-8iteddug	126	2	Secretins	Secretins	NNPS
cord-306904-8iteddug	126	3	(	(	-LRB-
cord-306904-8iteddug	126	4	including	include	VBG
cord-306904-8iteddug	126	5	PilQ	PilQ	NNP
cord-306904-8iteddug	126	6	sectretin	sectretin	NNP
cord-306904-8iteddug	126	7	)	)	-RRB-
cord-306904-8iteddug	126	8	possess	possess	VBP
cord-306904-8iteddug	126	9	a	a	DT
cord-306904-8iteddug	126	10	conserved	conserve	VBN
cord-306904-8iteddug	126	11	C	c	NN
cord-306904-8iteddug	126	12	-	-	HYPH
cord-306904-8iteddug	126	13	terminal	terminal	NN
cord-306904-8iteddug	126	14	region	region	NN
cord-306904-8iteddug	126	15	,	,	,
cord-306904-8iteddug	126	16	containing	contain	VBG
cord-306904-8iteddug	126	17	the	the	DT
cord-306904-8iteddug	126	18	secretin	secretin	NNS
cord-306904-8iteddug	126	19	domain	domain	NN
cord-306904-8iteddug	126	20	that	that	WDT
cord-306904-8iteddug	126	21	is	be	VBZ
cord-306904-8iteddug	126	22	putatively	putatively	RB
cord-306904-8iteddug	126	23	embedded	embed	VBN
cord-306904-8iteddug	126	24	into	into	IN
cord-306904-8iteddug	126	25	the	the	DT
cord-306904-8iteddug	126	26	outer	outer	JJ
cord-306904-8iteddug	126	27	membrane	membrane	NN
cord-306904-8iteddug	126	28	,	,	,
cord-306904-8iteddug	126	29	and	and	CC
cord-306904-8iteddug	126	30	a	a	DT
cord-306904-8iteddug	126	31	variable	variable	NN
cord-306904-8iteddug	126	32	,	,	,
cord-306904-8iteddug	126	33	system	system	NN
cord-306904-8iteddug	126	34	-	-	HYPH
cord-306904-8iteddug	126	35	specific	specific	JJ
cord-306904-8iteddug	126	36	N	n	CD
cord-306904-8iteddug	126	37	-	-	HYPH
cord-306904-8iteddug	126	38	terminal	terminal	NN
cord-306904-8iteddug	126	39	region	region	NN
cord-306904-8iteddug	126	40	.	.	.
cord-306904-8iteddug	127	1	34	34	CD
cord-306904-8iteddug	127	2	,	,	,
cord-306904-8iteddug	127	3	35	35	CD
cord-306904-8iteddug	127	4	Figure	figure	NN
cord-306904-8iteddug	127	5	4A	4a	CD
cord-306904-8iteddug	127	6	shows	show	VBZ
cord-306904-8iteddug	127	7	that	that	IN
cord-306904-8iteddug	127	8	the	the	DT
cord-306904-8iteddug	127	9	P.aeruginosa	p.aeruginosa	JJ
cord-306904-8iteddug	127	10	PilF	PilF	NNP
cord-306904-8iteddug	127	11	(	(	-LRB-
cord-306904-8iteddug	127	12	UniProt	UniProt	NNP
cord-306904-8iteddug	127	13	ID	ID	NNP
cord-306904-8iteddug	127	14	:	:	:
cord-306904-8iteddug	127	15	Q51385	Q51385	NNP
cord-306904-8iteddug	127	16	)	)	-RRB-
cord-306904-8iteddug	127	17	is	be	VBZ
cord-306904-8iteddug	127	18	predicted	predict	VBN
cord-306904-8iteddug	127	19	to	to	TO
cord-306904-8iteddug	127	20	be	be	VB
cord-306904-8iteddug	127	21	a	a	DT
cord-306904-8iteddug	127	22	hybrid	hybrid	JJ
cord-306904-8iteddug	127	23	protein	protein	NN
cord-306904-8iteddug	127	24	possessing	possess	VBG
cord-306904-8iteddug	127	25	both	both	CC
cord-306904-8iteddug	127	26	ordered	order	VBN
cord-306904-8iteddug	127	27	and	and	CC
cord-306904-8iteddug	127	28	disordered	disordered	JJ
cord-306904-8iteddug	127	29	regions	region	NNS
cord-306904-8iteddug	127	30	.	.	.
cord-306904-8iteddug	128	1	Curiously	curiously	RB
cord-306904-8iteddug	128	2	,	,	,
cord-306904-8iteddug	128	3	about	about	RB
cord-306904-8iteddug	128	4	2/3	2/3	CD
cord-306904-8iteddug	128	5	of	of	IN
cord-306904-8iteddug	128	6	this	this	DT
cord-306904-8iteddug	128	7	protein	protein	NN
cord-306904-8iteddug	128	8	possesses	possess	VBZ
cord-306904-8iteddug	128	9	disorder	disorder	NN
cord-306904-8iteddug	128	10	scores	score	NNS
cord-306904-8iteddug	128	11	close	close	JJ
cord-306904-8iteddug	128	12	to	to	IN
cord-306904-8iteddug	128	13	0.5	0.5	CD
cord-306904-8iteddug	128	14	.	.	.
cord-306904-8iteddug	129	1	This	this	DT
cord-306904-8iteddug	129	2	grayish	grayish	JJ
cord-306904-8iteddug	129	3	area	area	NN
cord-306904-8iteddug	129	4	is	be	VBZ
cord-306904-8iteddug	129	5	likely	likely	JJ
cord-306904-8iteddug	129	6	to	to	TO
cord-306904-8iteddug	129	7	be	be	VB
cord-306904-8iteddug	129	8	characterized	characterize	VBN
cord-306904-8iteddug	129	9	by	by	IN
cord-306904-8iteddug	129	10	high	high	JJ
cord-306904-8iteddug	129	11	conformational	conformational	JJ
cord-306904-8iteddug	129	12	plasticity	plasticity	NN
cord-306904-8iteddug	129	13	and	and	CC
cord-306904-8iteddug	129	14	is	be	VBZ
cord-306904-8iteddug	129	15	predicted	predict	VBN
cord-306904-8iteddug	129	16	to	to	TO
cord-306904-8iteddug	129	17	contain	contain	VB
cord-306904-8iteddug	129	18	4	4	CD
cord-306904-8iteddug	129	19	AiBSs	AiBSs	NNP
cord-306904-8iteddug	129	20	,	,	,
cord-306904-8iteddug	129	21	residues	residue	NNS
cord-306904-8iteddug	129	22	5	5	CD
cord-306904-8iteddug	129	23	-	-	SYM
cord-306904-8iteddug	129	24	16	16	CD
cord-306904-8iteddug	129	25	,	,	,
cord-306904-8iteddug	129	26	41	41	CD
cord-306904-8iteddug	129	27	-	-	SYM
cord-306904-8iteddug	129	28	46	46	CD
cord-306904-8iteddug	129	29	,	,	,
cord-306904-8iteddug	129	30	76	76	CD
cord-306904-8iteddug	129	31	-	-	SYM
cord-306904-8iteddug	129	32	81	81	CD
cord-306904-8iteddug	129	33	and	and	CC
cord-306904-8iteddug	129	34	111	111	CD
cord-306904-8iteddug	129	35	-	-	SYM
cord-306904-8iteddug	129	36	115	115	CD
cord-306904-8iteddug	129	37	.	.	.
cord-306904-8iteddug	130	1	Similarly	similarly	RB
cord-306904-8iteddug	130	2	,	,	,
cord-306904-8iteddug	130	3	PilQ	PilQ	NNP
cord-306904-8iteddug	130	4	(	(	-LRB-
cord-306904-8iteddug	130	5	UniProt	UniProt	NNP
cord-306904-8iteddug	130	6	ID	ID	NNP
cord-306904-8iteddug	130	7	:	:	:
cord-306904-8iteddug	130	8	P34750	P34750	NNP
cord-306904-8iteddug	130	9	)	)	-RRB-
cord-306904-8iteddug	130	10	is	be	VBZ
cord-306904-8iteddug	130	11	predicted	predict	VBN
cord-306904-8iteddug	130	12	to	to	TO
cord-306904-8iteddug	130	13	be	be	VB
cord-306904-8iteddug	130	14	a	a	DT
cord-306904-8iteddug	130	15	hybrid	hybrid	JJ
cord-306904-8iteddug	130	16	protein	protein	NN
cord-306904-8iteddug	130	17	(	(	-LRB-
cord-306904-8iteddug	130	18	see	see	VB
cord-306904-8iteddug	130	19	Fig	Fig	NNP
cord-306904-8iteddug	130	20	.	.	.
cord-306904-8iteddug	130	21	4B	4b	LS
cord-306904-8iteddug	130	22	)	)	-RRB-
cord-306904-8iteddug	130	23	with	with	IN
cord-306904-8iteddug	130	24	several	several	JJ
cord-306904-8iteddug	130	25	disorder	disorder	NN
cord-306904-8iteddug	130	26	-	-	HYPH
cord-306904-8iteddug	130	27	based	base	VBN
cord-306904-8iteddug	130	28	binding	binding	NN
cord-306904-8iteddug	130	29	sites	site	NNS
cord-306904-8iteddug	130	30	(	(	-LRB-
cord-306904-8iteddug	130	31	residues	residue	NNS
cord-306904-8iteddug	130	32	101	101	CD
cord-306904-8iteddug	130	33	-	-	SYM
cord-306904-8iteddug	130	34	107	107	CD
cord-306904-8iteddug	130	35	,	,	,
cord-306904-8iteddug	130	36	120	120	CD
cord-306904-8iteddug	130	37	-	-	SYM
cord-306904-8iteddug	130	38	122	122	CD
cord-306904-8iteddug	130	39	,	,	,
cord-306904-8iteddug	130	40	245	245	CD
cord-306904-8iteddug	130	41	-	-	SYM
cord-306904-8iteddug	130	42	251	251	CD
cord-306904-8iteddug	130	43	,	,	,
cord-306904-8iteddug	130	44	502	502	CD
cord-306904-8iteddug	130	45	-	-	SYM
cord-306904-8iteddug	130	46	505	505	CD
cord-306904-8iteddug	130	47	,	,	,
cord-306904-8iteddug	130	48	and	and	CC
cord-306904-8iteddug	130	49	533	533	CD
cord-306904-8iteddug	130	50	-	-	SYM
cord-306904-8iteddug	130	51	547	547	CD
cord-306904-8iteddug	130	52	)	)	-RRB-
cord-306904-8iteddug	130	53	.	.	.
cord-306904-8iteddug	131	1	Bonet	Bonet	NNP
cord-306904-8iteddug	131	2	et	et	NNP
cord-306904-8iteddug	131	3	al	al	NNP
cord-306904-8iteddug	131	4	.	.	.
cord-306904-8iteddug	131	5	analyzed	analyze	VBD
cord-306904-8iteddug	131	6	the	the	DT
cord-306904-8iteddug	131	7	molecular	molecular	JJ
cord-306904-8iteddug	131	8	mechanisms	mechanism	NNS
cord-306904-8iteddug	131	9	of	of	IN
cord-306904-8iteddug	131	10	interaction	interaction	NN
cord-306904-8iteddug	131	11	of	of	IN
cord-306904-8iteddug	131	12	the	the	DT
cord-306904-8iteddug	131	13	14	14	CD
cord-306904-8iteddug	131	14	-	-	SYM
cord-306904-8iteddug	131	15	3	3	CD
cord-306904-8iteddug	131	16	-	-	HYPH
cord-306904-8iteddug	131	17	3z	3z	NN
cord-306904-8iteddug	131	18	protein	protein	NN
cord-306904-8iteddug	131	19	with	with	IN
cord-306904-8iteddug	131	20	several	several	JJ
cord-306904-8iteddug	131	21	integrin	integrin	NN
cord-306904-8iteddug	131	22	proteins	protein	NNS
cord-306904-8iteddug	131	23	.	.	.
cord-306904-8iteddug	132	1	36	36	CD
cord-306904-8iteddug	133	1	The	the	DT
cord-306904-8iteddug	133	2	authors	author	NNS
cord-306904-8iteddug	133	3	provided	provide	VBD
cord-306904-8iteddug	133	4	a	a	DT
cord-306904-8iteddug	133	5	detailed	detailed	JJ
cord-306904-8iteddug	133	6	biophysical	biophysical	JJ
cord-306904-8iteddug	133	7	characterization	characterization	NN
cord-306904-8iteddug	133	8	of	of	IN
cord-306904-8iteddug	133	9	the	the	DT
cord-306904-8iteddug	133	10	cytoplasmic	cytoplasmic	JJ
cord-306904-8iteddug	133	11	tails	tail	NNS
cord-306904-8iteddug	133	12	of	of	IN
cord-306904-8iteddug	133	13	a4	a4	NN
cord-306904-8iteddug	133	14	,	,	,
cord-306904-8iteddug	133	15	b1	b1	NN
cord-306904-8iteddug	133	16	,	,	,
cord-306904-8iteddug	133	17	b2	b2	NN
cord-306904-8iteddug	133	18	and	and	CC
cord-306904-8iteddug	133	19	b3	b3	NN
cord-306904-8iteddug	133	20	integrins	integrin	NNS
cord-306904-8iteddug	133	21	binding	bind	VBG
cord-306904-8iteddug	133	22	to	to	IN
cord-306904-8iteddug	133	23	14	14	CD
cord-306904-8iteddug	133	24	-	-	SYM
cord-306904-8iteddug	133	25	3	3	CD
cord-306904-8iteddug	133	26	-	-	HYPH
cord-306904-8iteddug	133	27	3z	3z	CD
cord-306904-8iteddug	133	28	and	and	CC
cord-306904-8iteddug	133	29	showed	show	VBD
cord-306904-8iteddug	133	30	that	that	IN
cord-306904-8iteddug	133	31	binding	bind	VBG
cord-306904-8iteddug	133	32	affinities	affinity	NNS
cord-306904-8iteddug	133	33	and	and	CC
cord-306904-8iteddug	133	34	interaction	interaction	NN
cord-306904-8iteddug	133	35	modes	mode	NNS
cord-306904-8iteddug	133	36	of	of	IN
cord-306904-8iteddug	133	37	different	different	JJ
cord-306904-8iteddug	133	38	integrins	integrin	NNS
cord-306904-8iteddug	133	39	with	with	IN
cord-306904-8iteddug	133	40	this	this	DT
cord-306904-8iteddug	133	41	14	14	CD
cord-306904-8iteddug	133	42	-	-	SYM
cord-306904-8iteddug	133	43	3	3	CD
cord-306904-8iteddug	133	44	-	-	SYM
cord-306904-8iteddug	133	45	3	3	CD
cord-306904-8iteddug	133	46	are	be	VBP
cord-306904-8iteddug	133	47	rather	rather	RB
cord-306904-8iteddug	133	48	different	different	JJ
cord-306904-8iteddug	133	49	.	.	.
cord-306904-8iteddug	134	1	Furthermore	furthermore	RB
cord-306904-8iteddug	134	2	,	,	,
cord-306904-8iteddug	134	3	although	although	IN
cord-306904-8iteddug	134	4	many	many	JJ
cord-306904-8iteddug	134	5	structural	structural	JJ
cord-306904-8iteddug	134	6	features	feature	NNS
cord-306904-8iteddug	134	7	of	of	IN
cord-306904-8iteddug	134	8	these	these	DT
cord-306904-8iteddug	134	9	interactions	interaction	NNS
cord-306904-8iteddug	134	10	are	be	VBP
cord-306904-8iteddug	134	11	similar	similar	JJ
cord-306904-8iteddug	134	12	to	to	IN
cord-306904-8iteddug	134	13	other	other	JJ
cord-306904-8iteddug	134	14	known	know	VBN
cord-306904-8iteddug	134	15	14	14	CD
cord-306904-8iteddug	134	16	-	-	SYM
cord-306904-8iteddug	134	17	3	3	CD
cord-306904-8iteddug	134	18	-	-	SYM
cord-306904-8iteddug	134	19	3	3	CD
cord-306904-8iteddug	134	20	complexes	complex	NNS
cord-306904-8iteddug	134	21	,	,	,
cord-306904-8iteddug	134	22	the	the	DT
cord-306904-8iteddug	134	23	binding	bind	VBG
cord-306904-8iteddug	134	24	exhibits	exhibit	VBZ
cord-306904-8iteddug	134	25	specific	specific	JJ
cord-306904-8iteddug	134	26	features	feature	NNS
cord-306904-8iteddug	134	27	involving	involve	VBG
cord-306904-8iteddug	134	28	secondary	secondary	JJ
cord-306904-8iteddug	134	29	sites	site	NNS
cord-306904-8iteddug	134	30	.	.	.
cord-306904-8iteddug	135	1	Particularly	particularly	RB
cord-306904-8iteddug	135	2	,	,	,
cord-306904-8iteddug	135	3	in	in	IN
cord-306904-8iteddug	135	4	addition	addition	NN
cord-306904-8iteddug	135	5	to	to	IN
cord-306904-8iteddug	135	6	a	a	DT
cord-306904-8iteddug	135	7	canonical	canonical	JJ
cord-306904-8iteddug	135	8	binding	binding	NN
cord-306904-8iteddug	135	9	mode	mode	NN
cord-306904-8iteddug	135	10	for	for	IN
cord-306904-8iteddug	135	11	the	the	DT
cord-306904-8iteddug	135	12	a4	a4	NNP
cord-306904-8iteddug	135	13	phospho	phospho	NNP
cord-306904-8iteddug	135	14	-	-	HYPH
cord-306904-8iteddug	135	15	peptide	peptide	JJ
cord-306904-8iteddug	135	16	,	,	,
cord-306904-8iteddug	135	17	some	some	DT
cord-306904-8iteddug	135	18	residues	residue	NNS
cord-306904-8iteddug	135	19	outside	outside	IN
cord-306904-8iteddug	135	20	the	the	DT
cord-306904-8iteddug	135	21	consensus	consensus	NN
cord-306904-8iteddug	135	22	14	14	CD
cord-306904-8iteddug	135	23	-	-	SYM
cord-306904-8iteddug	135	24	3	3	CD
cord-306904-8iteddug	135	25	-	-	HYPH
cord-306904-8iteddug	135	26	3z	3z	NN
cord-306904-8iteddug	135	27	binding	binding	NN
cord-306904-8iteddug	135	28	motif	motif	NN
cord-306904-8iteddug	135	29	of	of	IN
cord-306904-8iteddug	135	30	this	this	DT
cord-306904-8iteddug	135	31	integrin	integrin	NN
cord-306904-8iteddug	135	32	were	be	VBD
cord-306904-8iteddug	135	33	shown	show	VBN
cord-306904-8iteddug	135	34	to	to	TO
cord-306904-8iteddug	135	35	be	be	VB
cord-306904-8iteddug	135	36	essential	essential	JJ
cord-306904-8iteddug	135	37	for	for	IN
cord-306904-8iteddug	135	38	an	an	DT
cord-306904-8iteddug	135	39	efficient	efficient	JJ
cord-306904-8iteddug	135	40	interaction	interaction	NN
cord-306904-8iteddug	135	41	.	.	.
cord-306904-8iteddug	136	1	Although	although	IN
cord-306904-8iteddug	136	2	a	a	DT
cord-306904-8iteddug	136	3	short	short	JJ
cord-306904-8iteddug	136	4	b2	b2	NN
cord-306904-8iteddug	136	5	phospho	phospho	NN
cord-306904-8iteddug	136	6	-	-	HYPH
cord-306904-8iteddug	136	7	peptide	peptide	NN
cord-306904-8iteddug	136	8	is	be	VBZ
cord-306904-8iteddug	136	9	sufficient	sufficient	JJ
cord-306904-8iteddug	136	10	for	for	IN
cord-306904-8iteddug	136	11	high	high	JJ
cord-306904-8iteddug	136	12	-	-	HYPH
cord-306904-8iteddug	136	13	affinity	affinity	NN
cord-306904-8iteddug	136	14	binding	binding	NN
cord-306904-8iteddug	136	15	to	to	IN
cord-306904-8iteddug	136	16	14	14	CD
cord-306904-8iteddug	136	17	-	-	SYM
cord-306904-8iteddug	136	18	3	3	CD
cord-306904-8iteddug	136	19	-	-	HYPH
cord-306904-8iteddug	136	20	3z	3z	CD
cord-306904-8iteddug	136	21	,	,	,
cord-306904-8iteddug	136	22	the	the	DT
cord-306904-8iteddug	136	23	authors	author	NNS
cord-306904-8iteddug	136	24	also	also	RB
cord-306904-8iteddug	136	25	found	find	VBD
cord-306904-8iteddug	136	26	novel	novel	JJ
cord-306904-8iteddug	136	27	14	14	CD
cord-306904-8iteddug	136	28	-	-	SYM
cord-306904-8iteddug	136	29	3	3	CD
cord-306904-8iteddug	136	30	-	-	HYPH
cord-306904-8iteddug	136	31	3z	3z	CD
cord-306904-8iteddug	136	32	/	/	SYM
cord-306904-8iteddug	136	33	integrin	integrin	NN
cord-306904-8iteddug	136	34	tail	tail	NN
cord-306904-8iteddug	136	35	interactions	interaction	NNS
cord-306904-8iteddug	136	36	that	that	WDT
cord-306904-8iteddug	136	37	were	be	VBD
cord-306904-8iteddug	136	38	independent	independent	JJ
cord-306904-8iteddug	136	39	of	of	IN
cord-306904-8iteddug	136	40	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	136	41	.	.	.
cord-306904-8iteddug	137	1	36	36	CD
cord-306904-8iteddug	138	1	The	the	DT
cord-306904-8iteddug	138	2	members	member	NNS
cord-306904-8iteddug	138	3	of	of	IN
cord-306904-8iteddug	138	4	the	the	DT
cord-306904-8iteddug	138	5	14	14	CD
cord-306904-8iteddug	138	6	-	-	SYM
cord-306904-8iteddug	138	7	3	3	CD
cord-306904-8iteddug	138	8	-	-	SYM
cord-306904-8iteddug	138	9	3	3	CD
cord-306904-8iteddug	138	10	family	family	NN
cord-306904-8iteddug	138	11	are	be	VBP
cord-306904-8iteddug	138	12	highly	highly	RB
cord-306904-8iteddug	138	13	conserved	conserved	JJ
cord-306904-8iteddug	138	14	acidic	acidic	JJ
cord-306904-8iteddug	138	15	proteins	protein	NNS
cord-306904-8iteddug	138	16	of	of	IN
cord-306904-8iteddug	138	17	»	»	$
cord-306904-8iteddug	138	18	30	30	CD
cord-306904-8iteddug	138	19	kDa	kDa	NNPS
cord-306904-8iteddug	138	20	that	that	WDT
cord-306904-8iteddug	138	21	are	be	VBP
cord-306904-8iteddug	138	22	abundantly	abundantly	RB
cord-306904-8iteddug	138	23	expressed	express	VBN
cord-306904-8iteddug	138	24	in	in	IN
cord-306904-8iteddug	138	25	all	all	DT
cord-306904-8iteddug	138	26	eukaryotic	eukaryotic	JJ
cord-306904-8iteddug	138	27	cells	cell	NNS
cord-306904-8iteddug	138	28	.	.	.
cord-306904-8iteddug	139	1	In	in	IN
cord-306904-8iteddug	139	2	human	human	NN
cord-306904-8iteddug	139	3	,	,	,
cord-306904-8iteddug	139	4	there	there	EX
cord-306904-8iteddug	139	5	are	be	VBP
cord-306904-8iteddug	139	6	7	7	CD
cord-306904-8iteddug	139	7	14	14	CD
cord-306904-8iteddug	139	8	-	-	HYPH
cord-306904-8iteddug	139	9	3	3	CD
cord-306904-8iteddug	139	10	-	-	SYM
cord-306904-8iteddug	139	11	3	3	CD
cord-306904-8iteddug	139	12	isoforms	isoform	NNS
cord-306904-8iteddug	139	13	(	(	-LRB-
cord-306904-8iteddug	139	14	b	b	NN
cord-306904-8iteddug	139	15	,	,	,
cord-306904-8iteddug	139	16	g	g	NNP
cord-306904-8iteddug	139	17	,	,	,
cord-306904-8iteddug	139	18	e	e	NNP
cord-306904-8iteddug	139	19	,	,	,
cord-306904-8iteddug	139	20	h	h	NNP
cord-306904-8iteddug	139	21	,	,	,
cord-306904-8iteddug	139	22	s	s	NNP
cord-306904-8iteddug	139	23	,	,	,
cord-306904-8iteddug	139	24	t	t	NNP
cord-306904-8iteddug	139	25	and	and	CC
cord-306904-8iteddug	139	26	z	z	LS
cord-306904-8iteddug	139	27	)	)	-RRB-
cord-306904-8iteddug	139	28	forming	form	VBG
cord-306904-8iteddug	139	29	homodimers	homodimer	NNS
cord-306904-8iteddug	139	30	or	or	CC
cord-306904-8iteddug	139	31	heterodimers	heterodimer	NNS
cord-306904-8iteddug	139	32	.	.	.
cord-306904-8iteddug	140	1	These	these	DT
cord-306904-8iteddug	140	2	proteins	protein	NNS
cord-306904-8iteddug	140	3	regulate	regulate	VBP
cord-306904-8iteddug	140	4	and	and	CC
cord-306904-8iteddug	140	5	control	control	VBP
cord-306904-8iteddug	140	6	many	many	JJ
cord-306904-8iteddug	140	7	signaling	signal	VBG
cord-306904-8iteddug	140	8	pathways	pathway	NNS
cord-306904-8iteddug	140	9	,	,	,
cord-306904-8iteddug	140	10	such	such	JJ
cord-306904-8iteddug	140	11	as	as	IN
cord-306904-8iteddug	140	12	cytoskeletal	cytoskeletal	JJ
cord-306904-8iteddug	140	13	dynamics	dynamic	NNS
cord-306904-8iteddug	140	14	programmed	program	VBD
cord-306904-8iteddug	140	15	cell	cell	NN
cord-306904-8iteddug	140	16	death	death	NN
cord-306904-8iteddug	140	17	,	,	,
cord-306904-8iteddug	140	18	and	and	CC
cord-306904-8iteddug	140	19	cell	cell	NN
cord-306904-8iteddug	140	20	cycle	cycle	NN
cord-306904-8iteddug	140	21	progression	progression	NN
cord-306904-8iteddug	140	22	,	,	,
cord-306904-8iteddug	140	23	and	and	CC
cord-306904-8iteddug	140	24	are	be	VBP
cord-306904-8iteddug	140	25	involved	involve	VBN
cord-306904-8iteddug	140	26	in	in	IN
cord-306904-8iteddug	140	27	the	the	DT
cord-306904-8iteddug	140	28	pathogenesis	pathogenesis	NN
cord-306904-8iteddug	140	29	of	of	IN
cord-306904-8iteddug	140	30	several	several	JJ
cord-306904-8iteddug	140	31	human	human	JJ
cord-306904-8iteddug	140	32	diseases	disease	NNS
cord-306904-8iteddug	140	33	,	,	,
cord-306904-8iteddug	140	34	such	such	JJ
cord-306904-8iteddug	140	35	as	as	IN
cord-306904-8iteddug	140	36	cancer	cancer	NN
cord-306904-8iteddug	140	37	and	and	CC
cord-306904-8iteddug	140	38	neurological	neurological	JJ
cord-306904-8iteddug	140	39	disorders	disorder	NNS
cord-306904-8iteddug	140	40	.	.	.
cord-306904-8iteddug	141	1	37,38	37,38	CD
cord-306904-8iteddug	141	2	Although	although	IN
cord-306904-8iteddug	141	3	14	14	CD
cord-306904-8iteddug	141	4	-	-	SYM
cord-306904-8iteddug	141	5	3	3	CD
cord-306904-8iteddug	141	6	-	-	SYM
cord-306904-8iteddug	141	7	3	3	CD
cord-306904-8iteddug	141	8	proteins	protein	NNS
cord-306904-8iteddug	141	9	are	be	VBP
cord-306904-8iteddug	141	10	considered	consider	VBN
cord-306904-8iteddug	141	11	as	as	IN
cord-306904-8iteddug	141	12	phosphor	phosphor	NN
cord-306904-8iteddug	141	13	-	-	HYPH
cord-306904-8iteddug	141	14	serine	serine	NN
cord-306904-8iteddug	141	15	/	/	SYM
cord-306904-8iteddug	141	16	threonine	threonine	NN
cord-306904-8iteddug	141	17	binding	bind	VBG
cord-306904-8iteddug	141	18	modules	module	NNS
cord-306904-8iteddug	141	19	possessing	possess	VBG
cord-306904-8iteddug	141	20	2	2	CD
cord-306904-8iteddug	141	21	consensus	consensus	NN
cord-306904-8iteddug	141	22	recognition	recognition	NN
cord-306904-8iteddug	141	23	motifs	motif	NNS
cord-306904-8iteddug	141	24	,	,	,
cord-306904-8iteddug	141	25	RSXpSXP	RSXpSXP	NNP
cord-306904-8iteddug	141	26	and	and	CC
cord-306904-8iteddug	141	27	RXF/	rxf/	CD
cord-306904-8iteddug	141	28	YXpSXP	yxpsxp	CD
cord-306904-8iteddug	141	29	,	,	,
cord-306904-8iteddug	142	1	39	39	CD
cord-306904-8iteddug	142	2	some	some	DT
cord-306904-8iteddug	142	3	other	other	JJ
cord-306904-8iteddug	142	4	binding	bind	VBG
cord-306904-8iteddug	142	5	modes	mode	NNS
cord-306904-8iteddug	142	6	are	be	VBP
cord-306904-8iteddug	142	7	known	know	VBN
cord-306904-8iteddug	142	8	including	include	VBG
cord-306904-8iteddug	142	9	interaction	interaction	NN
cord-306904-8iteddug	142	10	with	with	IN
cord-306904-8iteddug	142	11	some	some	DT
cord-306904-8iteddug	142	12	unphosphorylated	unphosphorylated	JJ
cord-306904-8iteddug	142	13	motifs	motif	NNS
cord-306904-8iteddug	142	14	.	.	.
cord-306904-8iteddug	143	1	40	40	CD
cord-306904-8iteddug	143	2	,	,	,
cord-306904-8iteddug	143	3	41	41	CD
cord-306904-8iteddug	143	4	X	x	NN
cord-306904-8iteddug	143	5	-	-	NN
cord-306904-8iteddug	143	6	ray	ray	JJ
cord-306904-8iteddug	143	7	structures	structure	NNS
cord-306904-8iteddug	143	8	of	of	IN
cord-306904-8iteddug	143	9	various	various	JJ
cord-306904-8iteddug	143	10	14	14	CD
cord-306904-8iteddug	143	11	-	-	SYM
cord-306904-8iteddug	143	12	3	3	CD
cord-306904-8iteddug	143	13	-	-	SYM
cord-306904-8iteddug	143	14	3	3	CD
cord-306904-8iteddug	143	15	isoforms	isoform	NNS
cord-306904-8iteddug	143	16	and	and	CC
cord-306904-8iteddug	143	17	their	-PRON-	PRP$
cord-306904-8iteddug	143	18	numerous	numerous	JJ
cord-306904-8iteddug	143	19	complexes	complex	NNS
cord-306904-8iteddug	143	20	are	be	VBP
cord-306904-8iteddug	143	21	known	know	VBN
cord-306904-8iteddug	143	22	providing	provide	VBG
cord-306904-8iteddug	143	23	considerable	considerable	JJ
cord-306904-8iteddug	143	24	knowledge	knowledge	NN
cord-306904-8iteddug	143	25	on	on	IN
cord-306904-8iteddug	143	26	the	the	DT
cord-306904-8iteddug	143	27	various	various	JJ
cord-306904-8iteddug	143	28	binding	binding	NN
cord-306904-8iteddug	143	29	modes	mode	NNS
cord-306904-8iteddug	143	30	.	.	.
cord-306904-8iteddug	144	1	42	42	CD
cord-306904-8iteddug	144	2	,	,	,
cord-306904-8iteddug	144	3	43	43	CD
cord-306904-8iteddug	145	1	Curiously	curiously	RB
cord-306904-8iteddug	145	2	,	,	,
cord-306904-8iteddug	145	3	a	a	DT
cord-306904-8iteddug	145	4	detailed	detailed	JJ
cord-306904-8iteddug	145	5	analysis	analysis	NN
cord-306904-8iteddug	145	6	of	of	IN
cord-306904-8iteddug	145	7	more	more	JJR
cord-306904-8iteddug	145	8	than	than	IN
cord-306904-8iteddug	145	9	200	200	CD
cord-306904-8iteddug	145	10	binding	bind	VBG
cord-306904-8iteddug	145	11	partners	partner	NNS
cord-306904-8iteddug	145	12	of	of	IN
cord-306904-8iteddug	145	13	14	14	CD
cord-306904-8iteddug	145	14	-	-	SYM
cord-306904-8iteddug	145	15	3	3	CD
cord-306904-8iteddug	145	16	-	-	SYM
cord-306904-8iteddug	145	17	3	3	CD
cord-306904-8iteddug	145	18	proteins	protein	NNS
cord-306904-8iteddug	145	19	showed	show	VBD
cord-306904-8iteddug	145	20	neither	neither	CC
cord-306904-8iteddug	145	21	structural	structural	JJ
cord-306904-8iteddug	145	22	nor	nor	CC
cord-306904-8iteddug	145	23	functional	functional	JJ
cord-306904-8iteddug	145	24	relatedness	relatedness	NN
cord-306904-8iteddug	145	25	in	in	IN
cord-306904-8iteddug	145	26	this	this	DT
cord-306904-8iteddug	145	27	group	group	NN
cord-306904-8iteddug	145	28	of	of	IN
cord-306904-8iteddug	145	29	proteins	protein	NNS
cord-306904-8iteddug	145	30	.	.	.
cord-306904-8iteddug	146	1	44	44	CD
cord-306904-8iteddug	147	1	However	however	RB
cord-306904-8iteddug	147	2	,	,	,
cord-306904-8iteddug	147	3	bioinformatics	bioinformatics	NN
cord-306904-8iteddug	147	4	analysis	analysis	NN
cord-306904-8iteddug	147	5	established	establish	VBN
cord-306904-8iteddug	147	6	that	that	IN
cord-306904-8iteddug	147	7	>	>	XX
cord-306904-8iteddug	147	8	90	90	CD
cord-306904-8iteddug	147	9	%	%	NN
cord-306904-8iteddug	147	10	of	of	IN
cord-306904-8iteddug	147	11	the	the	DT
cord-306904-8iteddug	147	12	14	14	CD
cord-306904-8iteddug	147	13	-	-	SYM
cord-306904-8iteddug	147	14	3	3	CD
cord-306904-8iteddug	147	15	-	-	SYM
cord-306904-8iteddug	147	16	3	3	CD
cord-306904-8iteddug	147	17	interactors	interactor	NNS
cord-306904-8iteddug	147	18	contain	contain	VBP
cord-306904-8iteddug	147	19	disordered	disordered	JJ
cord-306904-8iteddug	147	20	regions	region	NNS
cord-306904-8iteddug	147	21	and	and	CC
cord-306904-8iteddug	147	22	that	that	IN
cord-306904-8iteddug	147	23	almost	almost	RB
cord-306904-8iteddug	147	24	all	all	DT
cord-306904-8iteddug	147	25	14	14	CD
cord-306904-8iteddug	147	26	-	-	SYM
cord-306904-8iteddug	147	27	3	3	CD
cord-306904-8iteddug	147	28	-	-	HYPH
cord-306904-8iteddug	147	29	3-binding	3-binding	CD
cord-306904-8iteddug	147	30	sites	site	NNS
cord-306904-8iteddug	147	31	are	be	VBP
cord-306904-8iteddug	147	32	located	locate	VBN
cord-306904-8iteddug	147	33	inside	inside	IN
cord-306904-8iteddug	147	34	disordered	disordered	JJ
cord-306904-8iteddug	147	35	regions	region	NNS
cord-306904-8iteddug	147	36	.	.	.
cord-306904-8iteddug	148	1	44	44	CD
cord-306904-8iteddug	149	1	Among	among	IN
cord-306904-8iteddug	149	2	various	various	JJ
cord-306904-8iteddug	149	3	partners	partner	NNS
cord-306904-8iteddug	149	4	of	of	IN
cord-306904-8iteddug	149	5	14	14	CD
cord-306904-8iteddug	149	6	-	-	SYM
cord-306904-8iteddug	149	7	3	3	CD
cord-306904-8iteddug	149	8	-	-	SYM
cord-306904-8iteddug	149	9	3	3	CD
cord-306904-8iteddug	149	10	proteins	protein	NNS
cord-306904-8iteddug	149	11	are	be	VBP
cord-306904-8iteddug	149	12	membrane	membrane	NN
cord-306904-8iteddug	149	13	-	-	HYPH
cord-306904-8iteddug	149	14	spanning	span	VBG
cord-306904-8iteddug	149	15	receptors	receptor	NNS
cord-306904-8iteddug	149	16	,	,	,
cord-306904-8iteddug	149	17	integrins	integrin	NNS
cord-306904-8iteddug	149	18	,	,	,
cord-306904-8iteddug	149	19	which	which	WDT
cord-306904-8iteddug	149	20	are	be	VBP
cord-306904-8iteddug	149	21	involved	involve	VBN
cord-306904-8iteddug	149	22	in	in	IN
cord-306904-8iteddug	149	23	numerous	numerous	JJ
cord-306904-8iteddug	149	24	biological	biological	JJ
cord-306904-8iteddug	149	25	functions	function	NNS
cord-306904-8iteddug	149	26	,	,	,
cord-306904-8iteddug	149	27	such	such	JJ
cord-306904-8iteddug	149	28	as	as	IN
cord-306904-8iteddug	149	29	cell	cell	NN
cord-306904-8iteddug	149	30	adhesion	adhesion	NN
cord-306904-8iteddug	149	31	,	,	,
cord-306904-8iteddug	149	32	migration	migration	NN
cord-306904-8iteddug	149	33	and	and	CC
cord-306904-8iteddug	149	34	differentiation	differentiation	NN
cord-306904-8iteddug	149	35	and	and	CC
cord-306904-8iteddug	149	36	are	be	VBP
cord-306904-8iteddug	149	37	associated	associate	VBN
cord-306904-8iteddug	149	38	with	with	IN
cord-306904-8iteddug	149	39	a	a	DT
cord-306904-8iteddug	149	40	wide	wide	JJ
cord-306904-8iteddug	149	41	-	-	HYPH
cord-306904-8iteddug	149	42	range	range	NN
cord-306904-8iteddug	149	43	of	of	IN
cord-306904-8iteddug	149	44	diseases	disease	NNS
cord-306904-8iteddug	149	45	.	.	.
cord-306904-8iteddug	150	1	45	45	CD
cord-306904-8iteddug	150	2	,	,	,
cord-306904-8iteddug	150	3	46	46	CD
cord-306904-8iteddug	150	4	Integrins	Integrins	NNPS
cord-306904-8iteddug	150	5	are	be	VBP
cord-306904-8iteddug	150	6	heterodimers	heterodimer	NNS
cord-306904-8iteddug	150	7	formed	form	VBN
cord-306904-8iteddug	150	8	by	by	IN
cord-306904-8iteddug	150	9	aand	aand	NNP
cord-306904-8iteddug	150	10	b	b	NNP
cord-306904-8iteddug	150	11	-	-	:
cord-306904-8iteddug	150	12	subunits	subunit	NNS
cord-306904-8iteddug	150	13	composed	compose	VBN
cord-306904-8iteddug	150	14	of	of	IN
cord-306904-8iteddug	150	15	large	large	JJ
cord-306904-8iteddug	150	16	extracellular	extracellular	JJ
cord-306904-8iteddug	150	17	(	(	-LRB-
cord-306904-8iteddug	150	18	ecto	ecto	NNP
cord-306904-8iteddug	150	19	)	)	-RRB-
cord-306904-8iteddug	150	20	domains	domain	NNS
cord-306904-8iteddug	150	21	,	,	,
cord-306904-8iteddug	150	22	trans	trans	NN
cord-306904-8iteddug	150	23	-	-	NN
cord-306904-8iteddug	150	24	membrane	membrane	NN
cord-306904-8iteddug	150	25	domains	domain	NNS
cord-306904-8iteddug	150	26	and	and	CC
cord-306904-8iteddug	150	27	short	short	JJ
cord-306904-8iteddug	150	28	(	(	-LRB-
cord-306904-8iteddug	150	29	13	13	CD
cord-306904-8iteddug	150	30	-	-	SYM
cord-306904-8iteddug	150	31	70	70	CD
cord-306904-8iteddug	150	32	residues	residue	NNS
cord-306904-8iteddug	150	33	)	)	-RRB-
cord-306904-8iteddug	150	34	C	c	NN
cord-306904-8iteddug	150	35	-	-	HYPH
cord-306904-8iteddug	150	36	terminal	terminal	JJ
cord-306904-8iteddug	150	37	cytoplasmic	cytoplasmic	JJ
cord-306904-8iteddug	150	38	domains	domain	NNS
cord-306904-8iteddug	150	39	,	,	,
cord-306904-8iteddug	150	40	47	47	CD
cord-306904-8iteddug	150	41	which	which	WDT
cord-306904-8iteddug	150	42	are	be	VBP
cord-306904-8iteddug	150	43	flexible	flexible	JJ
cord-306904-8iteddug	150	44	tails	tail	NNS
cord-306904-8iteddug	150	45	acting	act	VBG
cord-306904-8iteddug	150	46	as	as	IN
cord-306904-8iteddug	150	47	hubs	hub	NNS
cord-306904-8iteddug	150	48	for	for	IN
cord-306904-8iteddug	150	49	numerous	numerous	JJ
cord-306904-8iteddug	150	50	integrin	integrin	NN
cord-306904-8iteddug	150	51	-	-	HYPH
cord-306904-8iteddug	150	52	based	base	VBN
cord-306904-8iteddug	150	53	protein	protein	NN
cord-306904-8iteddug	150	54	-	-	HYPH
cord-306904-8iteddug	150	55	protein	protein	NN
cord-306904-8iteddug	150	56	interactions	interaction	NNS
cord-306904-8iteddug	150	57	.	.	.
cord-306904-8iteddug	151	1	[	[	-LRB-
cord-306904-8iteddug	151	2	48	48	CD
cord-306904-8iteddug	151	3	]	]	-RRB-
cord-306904-8iteddug	151	4	[	[	-LRB-
cord-306904-8iteddug	151	5	49	49	CD
cord-306904-8iteddug	151	6	]	]	-RRB-
cord-306904-8iteddug	152	1	[	[	-LRB-
cord-306904-8iteddug	152	2	50	50	CD
cord-306904-8iteddug	152	3	]	]	-RRB-
cord-306904-8iteddug	153	1	These	these	DT
cord-306904-8iteddug	153	2	cytoplasmic	cytoplasmic	JJ
cord-306904-8iteddug	153	3	tails	tail	NNS
cord-306904-8iteddug	153	4	of	of	IN
cord-306904-8iteddug	153	5	the	the	DT
cord-306904-8iteddug	153	6	2	2	CD
cord-306904-8iteddug	153	7	integrin	integrin	NN
cord-306904-8iteddug	153	8	subunits	subunit	NNS
cord-306904-8iteddug	153	9	also	also	RB
cord-306904-8iteddug	153	10	mediates	mediate	VBZ
cord-306904-8iteddug	153	11	the	the	DT
cord-306904-8iteddug	153	12	bidirectional	bidirectional	JJ
cord-306904-8iteddug	153	13	inside	inside	JJ
cord-306904-8iteddug	153	14	-	-	HYPH
cord-306904-8iteddug	153	15	tooutside	tooutside	NN
cord-306904-8iteddug	153	16	and	and	CC
cord-306904-8iteddug	153	17	outside	outside	NN
cord-306904-8iteddug	153	18	-	-	HYPH
cord-306904-8iteddug	153	19	to	to	IN
cord-306904-8iteddug	153	20	-	-	HYPH
cord-306904-8iteddug	153	21	inside	inside	NN
cord-306904-8iteddug	153	22	signaling	signaling	NN
cord-306904-8iteddug	153	23	,	,	,
cord-306904-8iteddug	153	24	where	where	WRB
cord-306904-8iteddug	153	25	signals	signal	NNS
cord-306904-8iteddug	153	26	transmitted	transmit	VBN
cord-306904-8iteddug	153	27	by	by	IN
cord-306904-8iteddug	153	28	integrins	integrin	NNS
cord-306904-8iteddug	153	29	from	from	IN
cord-306904-8iteddug	153	30	outside	outside	RB
cord-306904-8iteddug	153	31	to	to	TO
cord-306904-8iteddug	153	32	inside	inside	IN
cord-306904-8iteddug	153	33	the	the	DT
cord-306904-8iteddug	153	34	cell	cell	NN
cord-306904-8iteddug	153	35	promote	promote	VBP
cord-306904-8iteddug	153	36	cell	cell	NN
cord-306904-8iteddug	153	37	survival	survival	NN
cord-306904-8iteddug	153	38	and	and	CC
cord-306904-8iteddug	153	39	proliferation	proliferation	NN
cord-306904-8iteddug	153	40	,	,	,
cord-306904-8iteddug	153	41	and	and	CC
cord-306904-8iteddug	153	42	where	where	WRB
cord-306904-8iteddug	153	43	integrin	integrin	JJ
cord-306904-8iteddug	153	44	affinity	affinity	NN
cord-306904-8iteddug	153	45	for	for	IN
cord-306904-8iteddug	153	46	the	the	DT
cord-306904-8iteddug	153	47	extracellular	extracellular	JJ
cord-306904-8iteddug	153	48	ligands	ligand	NNS
cord-306904-8iteddug	153	49	can	can	MD
cord-306904-8iteddug	153	50	also	also	RB
cord-306904-8iteddug	153	51	be	be	VB
cord-306904-8iteddug	153	52	controlled	control	VBN
cord-306904-8iteddug	153	53	by	by	IN
cord-306904-8iteddug	153	54	intracellular	intracellular	JJ
cord-306904-8iteddug	153	55	factors	factor	NNS
cord-306904-8iteddug	153	56	.	.	.
cord-306904-8iteddug	154	1	47	47	CD
cord-306904-8iteddug	154	2	Figure	figure	NN
cord-306904-8iteddug	154	3	5A	5a	NN
cord-306904-8iteddug	154	4	represents	represent	VBZ
cord-306904-8iteddug	154	5	a	a	DT
cord-306904-8iteddug	154	6	structure	structure	NN
cord-306904-8iteddug	154	7	of	of	IN
cord-306904-8iteddug	154	8	the	the	DT
cord-306904-8iteddug	154	9	complex	complex	NN
cord-306904-8iteddug	154	10	between	between	IN
cord-306904-8iteddug	154	11	the	the	DT
cord-306904-8iteddug	154	12	14	14	CD
cord-306904-8iteddug	154	13	-	-	SYM
cord-306904-8iteddug	154	14	3	3	CD
cord-306904-8iteddug	154	15	-	-	HYPH
cord-306904-8iteddug	154	16	3z	3z	CD
cord-306904-8iteddug	154	17	protein	protein	NN
cord-306904-8iteddug	154	18	(	(	-LRB-
cord-306904-8iteddug	154	19	blue	blue	JJ
cord-306904-8iteddug	154	20	cloud	cloud	NN
cord-306904-8iteddug	154	21	)	)	-RRB-
cord-306904-8iteddug	154	22	and	and	CC
cord-306904-8iteddug	154	23	a	a	DT
cord-306904-8iteddug	154	24	phosphorylated	phosphorylated	JJ
cord-306904-8iteddug	154	25	peptide	peptide	NN
cord-306904-8iteddug	154	26	from	from	IN
cord-306904-8iteddug	154	27	the	the	DT
cord-306904-8iteddug	154	28	b2	b2	NN
cord-306904-8iteddug	154	29	integrin	integrin	NN
cord-306904-8iteddug	154	30	tail	tail	NN
cord-306904-8iteddug	154	31	(	(	-LRB-
cord-306904-8iteddug	154	32	red	red	JJ
cord-306904-8iteddug	154	33	chain	chain	NN
cord-306904-8iteddug	154	34	)	)	-RRB-
cord-306904-8iteddug	154	35	.	.	.
cord-306904-8iteddug	155	1	51	51	CD
cord-306904-8iteddug	156	1	It	-PRON-	PRP
cord-306904-8iteddug	156	2	is	be	VBZ
cord-306904-8iteddug	156	3	seen	see	VBN
cord-306904-8iteddug	156	4	that	that	IN
cord-306904-8iteddug	156	5	similar	similar	JJ
cord-306904-8iteddug	156	6	to	to	IN
cord-306904-8iteddug	156	7	many	many	JJ
cord-306904-8iteddug	156	8	other	other	JJ
cord-306904-8iteddug	156	9	14	14	CD
cord-306904-8iteddug	156	10	-	-	SYM
cord-306904-8iteddug	156	11	3	3	CD
cord-306904-8iteddug	156	12	-	-	SYM
cord-306904-8iteddug	156	13	3	3	CD
cord-306904-8iteddug	156	14	complexes	complex	NNS
cord-306904-8iteddug	156	15	,	,	,
cord-306904-8iteddug	156	16	the	the	DT
cord-306904-8iteddug	156	17	b2	b2	NN
cord-306904-8iteddug	156	18	integrin	integrin	NN
cord-306904-8iteddug	156	19	tail	tail	NN
cord-306904-8iteddug	156	20	is	be	VBZ
cord-306904-8iteddug	156	21	bound	bind	VBN
cord-306904-8iteddug	156	22	in	in	IN
cord-306904-8iteddug	156	23	a	a	DT
cord-306904-8iteddug	156	24	highly	highly	RB
cord-306904-8iteddug	156	25	extended	extend	VBN
cord-306904-8iteddug	156	26	form	form	NN
cord-306904-8iteddug	156	27	.	.	.
cord-306904-8iteddug	157	1	To	to	TO
cord-306904-8iteddug	157	2	illustrate	illustrate	VB
cord-306904-8iteddug	157	3	interactivity	interactivity	NN
cord-306904-8iteddug	157	4	of	of	IN
cord-306904-8iteddug	157	5	the	the	DT
cord-306904-8iteddug	157	6	b2	b2	NN
cord-306904-8iteddug	157	7	integrin	integrin	NN
cord-306904-8iteddug	157	8	,	,	,
cord-306904-8iteddug	157	9	Figure	figure	NN
cord-306904-8iteddug	157	10	5B	5b	NN
cord-306904-8iteddug	157	11	shows	show	VBZ
cord-306904-8iteddug	157	12	the	the	DT
cord-306904-8iteddug	157	13	results	result	NNS
cord-306904-8iteddug	157	14	of	of	IN
cord-306904-8iteddug	157	15	the	the	DT
cord-306904-8iteddug	157	16	analysis	analysis	NN
cord-306904-8iteddug	157	17	of	of	IN
cord-306904-8iteddug	157	18	this	this	DT
cord-306904-8iteddug	157	19	protein	protein	NN
cord-306904-8iteddug	157	20	by	by	IN
cord-306904-8iteddug	157	21	STRING	string	NN
cord-306904-8iteddug	157	22	.	.	.
cord-306904-8iteddug	158	1	Here	here	RB
cord-306904-8iteddug	158	2	,	,	,
cord-306904-8iteddug	158	3	settings	setting	NNS
cord-306904-8iteddug	158	4	were	be	VBD
cord-306904-8iteddug	158	5	chosen	choose	VBN
cord-306904-8iteddug	158	6	to	to	TO
cord-306904-8iteddug	158	7	find	find	VB
cord-306904-8iteddug	158	8	binding	bind	VBG
cord-306904-8iteddug	158	9	partners	partner	NNS
cord-306904-8iteddug	158	10	with	with	IN
cord-306904-8iteddug	158	11	the	the	DT
cord-306904-8iteddug	158	12	highest	high	JJS
cord-306904-8iteddug	158	13	confidence	confidence	NN
cord-306904-8iteddug	158	14	(	(	-LRB-
cord-306904-8iteddug	158	15	0.9	0.9	CD
cord-306904-8iteddug	158	16	)	)	-RRB-
cord-306904-8iteddug	158	17	.	.	.
cord-306904-8iteddug	159	1	Finally	finally	RB
cord-306904-8iteddug	159	2	,	,	,
cord-306904-8iteddug	159	3	Figure	Figure	NNP
cord-306904-8iteddug	159	4	3C	3c	NN
cord-306904-8iteddug	159	5	shows	show	VBZ
cord-306904-8iteddug	159	6	some	some	DT
cord-306904-8iteddug	159	7	disorder	disorder	NN
cord-306904-8iteddug	159	8	-	-	HYPH
cord-306904-8iteddug	159	9	based	base	VBN
cord-306904-8iteddug	159	10	alignments	alignment	NNS
cord-306904-8iteddug	159	11	of	of	IN
cord-306904-8iteddug	159	12	the	the	DT
cord-306904-8iteddug	159	13	C	C	NNP
cord-306904-8iteddug	159	14	-	-	HYPH
cord-306904-8iteddug	159	15	terminal	terminal	NN
cord-306904-8iteddug	159	16	tails	tail	NNS
cord-306904-8iteddug	159	17	used	use	VBN
cord-306904-8iteddug	159	18	in	in	IN
cord-306904-8iteddug	159	19	the	the	DT
cord-306904-8iteddug	159	20	work	work	NN
cord-306904-8iteddug	159	21	of	of	IN
cord-306904-8iteddug	159	22	Bonet	Bonet	NNP
cord-306904-8iteddug	159	23	et	et	NNP
cord-306904-8iteddug	159	24	al	al	NNP
cord-306904-8iteddug	159	25	.	.	NNP
cord-306904-8iteddug	159	26	,	,	,
cord-306904-8iteddug	160	1	36	36	CD
cord-306904-8iteddug	160	2	namely	namely	RB
cord-306904-8iteddug	160	3	residues	residue	NNS
cord-306904-8iteddug	160	4	1001	1001	CD
cord-306904-8iteddug	160	5	-	-	SYM
cord-306904-8iteddug	160	6	1032	1032	CD
cord-306904-8iteddug	160	7	of	of	IN
cord-306904-8iteddug	160	8	human	human	JJ
cord-306904-8iteddug	160	9	integrin	integrin	NN
cord-306904-8iteddug	160	10	a4	a4	NNP
cord-306904-8iteddug	160	11	(	(	-LRB-
cord-306904-8iteddug	160	12	black	black	JJ
cord-306904-8iteddug	160	13	line	line	NN
cord-306904-8iteddug	160	14	,	,	,
cord-306904-8iteddug	160	15	UniProt	UniProt	NNP
cord-306904-8iteddug	160	16	ID	ID	NNP
cord-306904-8iteddug	160	17	P13612	P13612	NNP
cord-306904-8iteddug	160	18	)	)	-RRB-
cord-306904-8iteddug	160	19	,	,	,
cord-306904-8iteddug	160	20	residues	residue	VBZ
cord-306904-8iteddug	160	21	752	752	CD
cord-306904-8iteddug	160	22	-	-	HYPH
cord-306904-8iteddug	160	23	801	801	CD
cord-306904-8iteddug	160	24	of	of	IN
cord-306904-8iteddug	160	25	human	human	JJ
cord-306904-8iteddug	160	26	integrin	integrin	NN
cord-306904-8iteddug	160	27	b1	b1	NN
cord-306904-8iteddug	160	28	(	(	-LRB-
cord-306904-8iteddug	160	29	black	black	JJ
cord-306904-8iteddug	160	30	line	line	NN
cord-306904-8iteddug	160	31	,	,	,
cord-306904-8iteddug	160	32	UniProt	UniProt	NNP
cord-306904-8iteddug	160	33	ID	ID	NNP
cord-306904-8iteddug	160	34	P05556	P05556	NNP
cord-306904-8iteddug	160	35	)	)	-RRB-
cord-306904-8iteddug	160	36	,	,	,
cord-306904-8iteddug	160	37	residues	residue	VBZ
cord-306904-8iteddug	160	38	724	724	CD
cord-306904-8iteddug	160	39	-	-	SYM
cord-306904-8iteddug	160	40	769	769	CD
cord-306904-8iteddug	160	41	of	of	IN
cord-306904-8iteddug	160	42	human	human	JJ
cord-306904-8iteddug	160	43	integrin	integrin	NN
cord-306904-8iteddug	160	44	b2	b2	NN
cord-306904-8iteddug	160	45	(	(	-LRB-
cord-306904-8iteddug	160	46	black	black	JJ
cord-306904-8iteddug	160	47	line	line	NN
cord-306904-8iteddug	160	48	,	,	,
cord-306904-8iteddug	160	49	UniProt	UniProt	NNP
cord-306904-8iteddug	160	50	ID	ID	NNP
cord-306904-8iteddug	160	51	P05107	P05107	NNP
cord-306904-8iteddug	160	52	)	)	-RRB-
cord-306904-8iteddug	160	53	,	,	,
cord-306904-8iteddug	160	54	residues	residue	VBZ
cord-306904-8iteddug	160	55	742	742	CD
cord-306904-8iteddug	160	56	-	-	SYM
cord-306904-8iteddug	160	57	788	788	CD
cord-306904-8iteddug	160	58	of	of	IN
cord-306904-8iteddug	160	59	human	human	JJ
cord-306904-8iteddug	160	60	integrin	integrin	NN
cord-306904-8iteddug	160	61	b3	b3	NNP
cord-306904-8iteddug	160	62	(	(	-LRB-
cord-306904-8iteddug	160	63	black	black	JJ
cord-306904-8iteddug	160	64	line	line	NN
cord-306904-8iteddug	160	65	,	,	,
cord-306904-8iteddug	160	66	UniProt	UniProt	NNP
cord-306904-8iteddug	160	67	ID	ID	NNP
cord-306904-8iteddug	160	68	P05106	P05106	NNP
cord-306904-8iteddug	160	69	)	)	-RRB-
cord-306904-8iteddug	160	70	,	,	,
cord-306904-8iteddug	160	71	and	and	CC
cord-306904-8iteddug	160	72	residues	residue	VBZ
cord-306904-8iteddug	160	73	747	747	CD
cord-306904-8iteddug	160	74	-	-	HYPH
cord-306904-8iteddug	160	75	798	798	CD
cord-306904-8iteddug	160	76	of	of	IN
cord-306904-8iteddug	160	77	human	human	JJ
cord-306904-8iteddug	160	78	integrin	integrin	NN
cord-306904-8iteddug	160	79	b7	b7	NNP
cord-306904-8iteddug	160	80	(	(	-LRB-
cord-306904-8iteddug	160	81	black	black	JJ
cord-306904-8iteddug	160	82	line	line	NN
cord-306904-8iteddug	160	83	,	,	,
cord-306904-8iteddug	160	84	UniProt	UniProt	NNP
cord-306904-8iteddug	160	85	ID	ID	NNP
cord-306904-8iteddug	160	86	P26010	P26010	NNP
cord-306904-8iteddug	160	87	)	)	-RRB-
cord-306904-8iteddug	160	88	.	.	.
cord-306904-8iteddug	161	1	Figure	figure	NN
cord-306904-8iteddug	161	2	5C	5c	CD
cord-306904-8iteddug	161	3	clearly	clearly	RB
cord-306904-8iteddug	161	4	shows	show	VBZ
cord-306904-8iteddug	161	5	that	that	IN
cord-306904-8iteddug	161	6	all	all	PDT
cord-306904-8iteddug	161	7	these	these	DT
cord-306904-8iteddug	161	8	integrin	integrin	NN
cord-306904-8iteddug	161	9	tails	tail	NNS
cord-306904-8iteddug	161	10	involved	involve	VBN
cord-306904-8iteddug	161	11	in	in	IN
cord-306904-8iteddug	161	12	the	the	DT
cord-306904-8iteddug	161	13	specific	specific	JJ
cord-306904-8iteddug	161	14	interaction	interaction	NN
cord-306904-8iteddug	161	15	with	with	IN
cord-306904-8iteddug	161	16	the	the	DT
cord-306904-8iteddug	161	17	14	14	CD
cord-306904-8iteddug	161	18	-	-	SYM
cord-306904-8iteddug	161	19	3	3	CD
cord-306904-8iteddug	161	20	-	-	HYPH
cord-306904-8iteddug	161	21	3z	3z	CD
cord-306904-8iteddug	161	22	protein	protein	NN
cord-306904-8iteddug	161	23	are	be	VBP
cord-306904-8iteddug	161	24	mostly	mostly	RB
cord-306904-8iteddug	161	25	disordered	disordered	JJ
cord-306904-8iteddug	161	26	.	.	.
cord-306904-8iteddug	162	1	In	in	IN
cord-306904-8iteddug	162	2	the	the	DT
cord-306904-8iteddug	162	3	review	review	NN
cord-306904-8iteddug	162	4	by	by	IN
cord-306904-8iteddug	162	5	Rajsbaum	Rajsbaum	NNP
cord-306904-8iteddug	162	6	et	et	NNP
cord-306904-8iteddug	162	7	al	al	NNP
cord-306904-8iteddug	162	8	.	.	NNP
cord-306904-8iteddug	162	9	,	,	,
cord-306904-8iteddug	162	10	an	an	DT
cord-306904-8iteddug	162	11	important	important	JJ
cord-306904-8iteddug	162	12	family	family	NN
cord-306904-8iteddug	162	13	of	of	IN
cord-306904-8iteddug	162	14	proteins	protein	NNS
cord-306904-8iteddug	162	15	,	,	,
cord-306904-8iteddug	162	16	tripartite	tripartite	JJ
cord-306904-8iteddug	162	17	motif	motif	NN
cord-306904-8iteddug	162	18	(	(	-LRB-
cord-306904-8iteddug	162	19	TRIM	trim	NN
cord-306904-8iteddug	162	20	)	)	-RRB-
cord-306904-8iteddug	162	21	proteins	protein	NNS
cord-306904-8iteddug	162	22	is	be	VBZ
cord-306904-8iteddug	162	23	introduced	introduce	VBN
cord-306904-8iteddug	162	24	together	together	RB
cord-306904-8iteddug	162	25	with	with	IN
cord-306904-8iteddug	162	26	the	the	DT
cord-306904-8iteddug	162	27	multitude	multitude	NN
cord-306904-8iteddug	162	28	of	of	IN
cord-306904-8iteddug	162	29	their	-PRON-	PRP$
cord-306904-8iteddug	162	30	functional	functional	JJ
cord-306904-8iteddug	162	31	roles	role	NNS
cord-306904-8iteddug	162	32	in	in	IN
cord-306904-8iteddug	162	33	the	the	DT
cord-306904-8iteddug	162	34	innate	innate	JJ
cord-306904-8iteddug	162	35	antiviral	antiviral	JJ
cord-306904-8iteddug	162	36	immunity	immunity	NN
cord-306904-8iteddug	162	37	.	.	.
cord-306904-8iteddug	163	1	52	52	CD
cord-306904-8iteddug	164	1	Since	since	IN
cord-306904-8iteddug	164	2	there	there	EX
cord-306904-8iteddug	164	3	are	be	VBP
cord-306904-8iteddug	164	4	more	more	JJR
cord-306904-8iteddug	164	5	than	than	IN
cord-306904-8iteddug	164	6	70	70	CD
cord-306904-8iteddug	164	7	distinct	distinct	JJ
cord-306904-8iteddug	164	8	members	member	NNS
cord-306904-8iteddug	164	9	in	in	IN
cord-306904-8iteddug	164	10	the	the	DT
cord-306904-8iteddug	164	11	family	family	NN
cord-306904-8iteddug	164	12	of	of	IN
cord-306904-8iteddug	164	13	human	human	JJ
cord-306904-8iteddug	164	14	TRIM	trim	NN
cord-306904-8iteddug	164	15	proteins	protein	NNS
cord-306904-8iteddug	164	16	,	,	,
cord-306904-8iteddug	164	17	it	-PRON-	PRP
cord-306904-8iteddug	164	18	is	be	VBZ
cord-306904-8iteddug	164	19	physically	physically	RB
cord-306904-8iteddug	164	20	impossible	impossible	JJ
cord-306904-8iteddug	164	21	to	to	TO
cord-306904-8iteddug	164	22	consider	consider	VB
cord-306904-8iteddug	164	23	all	all	DT
cord-306904-8iteddug	164	24	of	of	IN
cord-306904-8iteddug	164	25	them	-PRON-	PRP
cord-306904-8iteddug	164	26	even	even	RB
cord-306904-8iteddug	164	27	very	very	RB
cord-306904-8iteddug	164	28	superficially	superficially	RB
cord-306904-8iteddug	164	29	.	.	.
cord-306904-8iteddug	165	1	The	the	DT
cord-306904-8iteddug	165	2	feature	feature	NN
cord-306904-8iteddug	165	3	that	that	WDT
cord-306904-8iteddug	165	4	links	link	VBZ
cord-306904-8iteddug	165	5	all	all	PDT
cord-306904-8iteddug	165	6	these	these	DT
cord-306904-8iteddug	165	7	proteins	protein	NNS
cord-306904-8iteddug	165	8	together	together	RB
cord-306904-8iteddug	165	9	is	be	VBZ
cord-306904-8iteddug	165	10	the	the	DT
cord-306904-8iteddug	165	11	fact	fact	NN
cord-306904-8iteddug	165	12	that	that	IN
cord-306904-8iteddug	165	13	they	-PRON-	PRP
cord-306904-8iteddug	165	14	share	share	VBP
cord-306904-8iteddug	165	15	3	3	CD
cord-306904-8iteddug	165	16	conserved	conserve	VBD
cord-306904-8iteddug	165	17	N	n	CD
cord-306904-8iteddug	165	18	-	-	HYPH
cord-306904-8iteddug	165	19	terminal	terminal	NN
cord-306904-8iteddug	165	20	domains	domain	NNS
cord-306904-8iteddug	165	21	:	:	:
cord-306904-8iteddug	165	22	a	a	DT
cord-306904-8iteddug	165	23	Really	really	RB
cord-306904-8iteddug	165	24	Interesting	interesting	JJ
cord-306904-8iteddug	165	25	New	New	NNP
cord-306904-8iteddug	165	26	Gene	Gene	NNP
cord-306904-8iteddug	165	27	(	(	-LRB-
cord-306904-8iteddug	165	28	RING	ring	NN
cord-306904-8iteddug	165	29	)	)	-RRB-
cord-306904-8iteddug	165	30	domain	domain	NN
cord-306904-8iteddug	165	31	,	,	,
cord-306904-8iteddug	165	32	one	one	CD
cord-306904-8iteddug	165	33	or	or	CC
cord-306904-8iteddug	165	34	2	2	CD
cord-306904-8iteddug	165	35	B	b	NN
cord-306904-8iteddug	165	36	-	-	HYPH
cord-306904-8iteddug	165	37	Boxes	Boxes	NNP
cord-306904-8iteddug	165	38	(	(	-LRB-
cord-306904-8iteddug	165	39	B1	b1	NN
cord-306904-8iteddug	165	40	/	/	SYM
cord-306904-8iteddug	165	41	B2	b2	NN
cord-306904-8iteddug	165	42	)	)	-RRB-
cord-306904-8iteddug	165	43	and	and	CC
cord-306904-8iteddug	165	44	a	a	DT
cord-306904-8iteddug	165	45	coiledcoil	coiledcoil	NNP
cord-306904-8iteddug	165	46	domain	domain	NN
cord-306904-8iteddug	165	47	.	.	.
cord-306904-8iteddug	166	1	[	[	-LRB-
cord-306904-8iteddug	166	2	53	53	CD
cord-306904-8iteddug	166	3	]	]	-RRB-
cord-306904-8iteddug	166	4	[	[	-LRB-
cord-306904-8iteddug	166	5	54	54	CD
cord-306904-8iteddug	166	6	]	]	-RRB-
cord-306904-8iteddug	167	1	[	[	-LRB-
cord-306904-8iteddug	167	2	55	55	CD
cord-306904-8iteddug	167	3	]	]	-RRB-
cord-306904-8iteddug	168	1	[	[	-LRB-
cord-306904-8iteddug	168	2	56	56	CD
cord-306904-8iteddug	168	3	]	]	-RRB-
cord-306904-8iteddug	169	1	In	in	IN
cord-306904-8iteddug	169	2	addition	addition	NN
cord-306904-8iteddug	169	3	to	to	IN
cord-306904-8iteddug	169	4	immunerelated	immunerelate	VBN
cord-306904-8iteddug	169	5	functions	function	NNS
cord-306904-8iteddug	169	6	many	many	JJ
cord-306904-8iteddug	169	7	TRIM	trim	JJ
cord-306904-8iteddug	169	8	proteins	protein	NNS
cord-306904-8iteddug	169	9	are	be	VBP
cord-306904-8iteddug	169	10	involved	involve	VBN
cord-306904-8iteddug	169	11	in	in	IN
cord-306904-8iteddug	169	12	a	a	DT
cord-306904-8iteddug	169	13	wide	wide	JJ
cord-306904-8iteddug	169	14	range	range	NN
cord-306904-8iteddug	169	15	of	of	IN
cord-306904-8iteddug	169	16	biological	biological	JJ
cord-306904-8iteddug	169	17	activities	activity	NNS
cord-306904-8iteddug	169	18	,	,	,
cord-306904-8iteddug	169	19	such	such	JJ
cord-306904-8iteddug	169	20	as	as	IN
cord-306904-8iteddug	169	21	transcriptional	transcriptional	JJ
cord-306904-8iteddug	169	22	regulation	regulation	NN
cord-306904-8iteddug	169	23	,	,	,
cord-306904-8iteddug	169	24	apoptosis	apoptosis	NN
cord-306904-8iteddug	169	25	,	,	,
cord-306904-8iteddug	169	26	cell	cell	NN
cord-306904-8iteddug	169	27	differentiation	differentiation	NN
cord-306904-8iteddug	169	28	,	,	,
cord-306904-8iteddug	169	29	development	development	NN
cord-306904-8iteddug	169	30	,	,	,
cord-306904-8iteddug	169	31	oncogenesis	oncogenesis	NNP
cord-306904-8iteddug	169	32	,	,	,
cord-306904-8iteddug	169	33	ubiquitin	ubiquitin	NNP
cord-306904-8iteddug	169	34	E3	e3	NN
cord-306904-8iteddug	169	35	ligases	ligase	NNS
cord-306904-8iteddug	169	36	,	,	,
cord-306904-8iteddug	169	37	and	and	CC
cord-306904-8iteddug	169	38	E3	e3	NN
cord-306904-8iteddug	169	39	ligases	ligase	NNS
cord-306904-8iteddug	169	40	for	for	IN
cord-306904-8iteddug	169	41	other	other	JJ
cord-306904-8iteddug	169	42	ubiquitinlike	ubiquitinlike	NN
cord-306904-8iteddug	169	43	molecules	molecule	NNS
cord-306904-8iteddug	169	44	such	such	JJ
cord-306904-8iteddug	169	45	as	as	IN
cord-306904-8iteddug	169	46	SUMO	SUMO	NNP
cord-306904-8iteddug	169	47	and	and	CC
cord-306904-8iteddug	169	48	the	the	DT
cord-306904-8iteddug	169	49	IFN	IFN	NNP
cord-306904-8iteddug	169	50	-	-	HYPH
cord-306904-8iteddug	169	51	inducible	inducible	JJ
cord-306904-8iteddug	169	52	protein	protein	NN
cord-306904-8iteddug	169	53	ISG15	isg15	NN
cord-306904-8iteddug	169	54	.	.	.
cord-306904-8iteddug	170	1	57	57	CD
cord-306904-8iteddug	170	2	Computational	computational	JJ
cord-306904-8iteddug	170	3	analysis	analysis	NN
cord-306904-8iteddug	170	4	(	(	-LRB-
cord-306904-8iteddug	170	5	see	see	VB
cord-306904-8iteddug	170	6	Table	table	NN
cord-306904-8iteddug	170	7	1	1	CD
cord-306904-8iteddug	170	8	)	)	-RRB-
cord-306904-8iteddug	170	9	revealed	reveal	VBD
cord-306904-8iteddug	170	10	that	that	IN
cord-306904-8iteddug	170	11	all	all	DT
cord-306904-8iteddug	170	12	members	member	NNS
cord-306904-8iteddug	170	13	of	of	IN
cord-306904-8iteddug	170	14	the	the	DT
cord-306904-8iteddug	170	15	human	human	JJ
cord-306904-8iteddug	170	16	TRIM	trim	NN
cord-306904-8iteddug	170	17	family	family	NN
cord-306904-8iteddug	170	18	are	be	VBP
cord-306904-8iteddug	170	19	extensively	extensively	RB
cord-306904-8iteddug	170	20	disordered	disordered	JJ
cord-306904-8iteddug	170	21	.	.	.
cord-306904-8iteddug	171	1	Helbig	Helbig	NNP
cord-306904-8iteddug	171	2	and	and	CC
cord-306904-8iteddug	171	3	Beard	Beard	NNP
cord-306904-8iteddug	171	4	overviewed	overviewe	VBD
cord-306904-8iteddug	171	5	the	the	DT
cord-306904-8iteddug	171	6	ability	ability	NN
cord-306904-8iteddug	171	7	of	of	IN
cord-306904-8iteddug	171	8	viperin	viperin	NNP
cord-306904-8iteddug	171	9	to	to	TO
cord-306904-8iteddug	171	10	modulate	modulate	VB
cord-306904-8iteddug	171	11	conditions	condition	NNS
cord-306904-8iteddug	171	12	within	within	IN
cord-306904-8iteddug	171	13	the	the	DT
cord-306904-8iteddug	171	14	cell	cell	NN
cord-306904-8iteddug	171	15	and	and	CC
cord-306904-8iteddug	171	16	to	to	TO
cord-306904-8iteddug	171	17	interfere	interfere	VB
cord-306904-8iteddug	171	18	with	with	IN
cord-306904-8iteddug	171	19	proviral	proviral	JJ
cord-306904-8iteddug	171	20	host	host	NN
cord-306904-8iteddug	171	21	proteins	protein	NNS
cord-306904-8iteddug	171	22	in	in	IN
cord-306904-8iteddug	171	23	order	order	NN
cord-306904-8iteddug	171	24	to	to	TO
cord-306904-8iteddug	171	25	create	create	VB
cord-306904-8iteddug	171	26	an	an	DT
cord-306904-8iteddug	171	27	unfavorable	unfavorable	JJ
cord-306904-8iteddug	171	28	environment	environment	NN
cord-306904-8iteddug	171	29	for	for	IN
cord-306904-8iteddug	171	30	viral	viral	JJ
cord-306904-8iteddug	171	31	replication	replication	NN
cord-306904-8iteddug	171	32	.	.	.
cord-306904-8iteddug	172	1	58	58	CD
cord-306904-8iteddug	172	2	Viperin	Viperin	NNP
cord-306904-8iteddug	172	3	is	be	VBZ
cord-306904-8iteddug	172	4	one	one	CD
cord-306904-8iteddug	172	5	of	of	IN
cord-306904-8iteddug	172	6	the	the	DT
cord-306904-8iteddug	172	7	few	few	JJ
cord-306904-8iteddug	172	8	products	product	NNS
cord-306904-8iteddug	172	9	of	of	IN
cord-306904-8iteddug	172	10	numerous	numerous	JJ
cord-306904-8iteddug	172	11	interferon	interferon	NN
cord-306904-8iteddug	172	12	-	-	HYPH
cord-306904-8iteddug	172	13	stimulated	stimulate	VBN
cord-306904-8iteddug	172	14	genes	gene	NNS
cord-306904-8iteddug	172	15	(	(	-LRB-
cord-306904-8iteddug	172	16	ISGs	ISGs	NNP
cord-306904-8iteddug	172	17	)	)	-RRB-
cord-306904-8iteddug	172	18	possessing	possess	VBG
cord-306904-8iteddug	172	19	direct	direct	JJ
cord-306904-8iteddug	172	20	antiviral	antiviral	JJ
cord-306904-8iteddug	172	21	activity	activity	NN
cord-306904-8iteddug	172	22	,	,	,
cord-306904-8iteddug	172	23	being	be	VBG
cord-306904-8iteddug	172	24	able	able	JJ
cord-306904-8iteddug	172	25	to	to	TO
cord-306904-8iteddug	172	26	limit	limit	VB
cord-306904-8iteddug	172	27	a	a	DT
cord-306904-8iteddug	172	28	broad	broad	JJ
cord-306904-8iteddug	172	29	range	range	NN
cord-306904-8iteddug	172	30	of	of	IN
cord-306904-8iteddug	172	31	viruses	virus	NNS
cord-306904-8iteddug	172	32	and	and	CC
cord-306904-8iteddug	172	33	to	to	TO
cord-306904-8iteddug	172	34	play	play	VB
cord-306904-8iteddug	172	35	an	an	DT
cord-306904-8iteddug	172	36	emerging	emerge	VBG
cord-306904-8iteddug	172	37	role	role	NN
cord-306904-8iteddug	172	38	in	in	IN
cord-306904-8iteddug	172	39	modulating	modulate	VBG
cord-306904-8iteddug	172	40	innate	innate	JJ
cord-306904-8iteddug	172	41	immune	immune	JJ
cord-306904-8iteddug	172	42	signaling	signaling	NN
cord-306904-8iteddug	172	43	.	.	.
cord-306904-8iteddug	173	1	This	this	DT
cord-306904-8iteddug	173	2	is	be	VBZ
cord-306904-8iteddug	173	3	a	a	DT
cord-306904-8iteddug	173	4	highly	highly	RB
cord-306904-8iteddug	173	5	species	species	NN
cord-306904-8iteddug	173	6	conserved	conserve	VBN
cord-306904-8iteddug	173	7	protein	protein	NN
cord-306904-8iteddug	173	8	consisting	consist	VBG
cord-306904-8iteddug	173	9	of	of	IN
cord-306904-8iteddug	173	10	3	3	CD
cord-306904-8iteddug	173	11	distinct	distinct	JJ
cord-306904-8iteddug	173	12	domains	domain	NNS
cord-306904-8iteddug	173	13	:	:	:
cord-306904-8iteddug	173	14	a	a	DT
cord-306904-8iteddug	173	15	variable	variable	JJ
cord-306904-8iteddug	173	16	N	n	CD
cord-306904-8iteddug	173	17	-	-	HYPH
cord-306904-8iteddug	173	18	terminal	terminal	NN
cord-306904-8iteddug	173	19	domain	domain	NN
cord-306904-8iteddug	173	20	that	that	WDT
cord-306904-8iteddug	173	21	contains	contain	VBZ
cord-306904-8iteddug	173	22	an	an	DT
cord-306904-8iteddug	173	23	amphipathic	amphipathic	JJ
cord-306904-8iteddug	173	24	helix	helix	NN
cord-306904-8iteddug	173	25	and	and	CC
cord-306904-8iteddug	173	26	a	a	DT
cord-306904-8iteddug	173	27	leucine	leucine	NN
cord-306904-8iteddug	173	28	zipper	zipper	NN
cord-306904-8iteddug	173	29	region	region	NN
cord-306904-8iteddug	173	30	,	,	,
cord-306904-8iteddug	173	31	a	a	DT
cord-306904-8iteddug	173	32	highly	highly	RB
cord-306904-8iteddug	173	33	conserved	conserved	JJ
cord-306904-8iteddug	173	34	central	central	JJ
cord-306904-8iteddug	173	35	domain	domain	NN
cord-306904-8iteddug	173	36	containing	contain	VBG
cord-306904-8iteddug	173	37	a	a	DT
cord-306904-8iteddug	173	38	"	"	``
cord-306904-8iteddug	173	39	radical	radical	JJ
cord-306904-8iteddug	173	40	SAM	SAM	NNP
cord-306904-8iteddug	173	41	domain	domain	NN
cord-306904-8iteddug	173	42	,	,	,
cord-306904-8iteddug	173	43	"	"	''
cord-306904-8iteddug	173	44	and	and	CC
cord-306904-8iteddug	173	45	a	a	DT
cord-306904-8iteddug	173	46	conserved	conserved	JJ
cord-306904-8iteddug	173	47	C	c	NN
cord-306904-8iteddug	173	48	-	-	HYPH
cord-306904-8iteddug	173	49	terminal	terminal	NN
cord-306904-8iteddug	173	50	critical	critical	NN
cord-306904-8iteddug	173	51	for	for	IN
cord-306904-8iteddug	173	52	the	the	DT
cord-306904-8iteddug	173	53	antiviral	antiviral	JJ
cord-306904-8iteddug	173	54	properties	property	NNS
cord-306904-8iteddug	173	55	of	of	IN
cord-306904-8iteddug	173	56	viperin	viperin	NNP
cord-306904-8iteddug	173	57	against	against	IN
cord-306904-8iteddug	173	58	a	a	DT
cord-306904-8iteddug	173	59	number	number	NN
cord-306904-8iteddug	173	60	of	of	IN
cord-306904-8iteddug	173	61	viruses	virus	NNS
cord-306904-8iteddug	173	62	.	.	.
cord-306904-8iteddug	174	1	58	58	CD
cord-306904-8iteddug	175	1	The	the	DT
cord-306904-8iteddug	175	2	authors	author	NNS
cord-306904-8iteddug	175	3	showed	show	VBD
cord-306904-8iteddug	175	4	that	that	IN
cord-306904-8iteddug	175	5	viperin	viperin	NNP
cord-306904-8iteddug	175	6	plays	play	VBZ
cord-306904-8iteddug	175	7	a	a	DT
cord-306904-8iteddug	175	8	role	role	NN
cord-306904-8iteddug	175	9	in	in	IN
cord-306904-8iteddug	175	10	innate	innate	JJ
cord-306904-8iteddug	175	11	immune	immune	JJ
cord-306904-8iteddug	175	12	signaling	signaling	NN
cord-306904-8iteddug	175	13	,	,	,
cord-306904-8iteddug	175	14	limits	limit	VBZ
cord-306904-8iteddug	175	15	different	different	JJ
cord-306904-8iteddug	175	16	viruses	virus	NNS
cord-306904-8iteddug	175	17	through	through	IN
cord-306904-8iteddug	175	18	both	both	CC
cord-306904-8iteddug	175	19	direct	direct	JJ
cord-306904-8iteddug	175	20	inhibition	inhibition	NN
cord-306904-8iteddug	175	21	of	of	IN
cord-306904-8iteddug	175	22	replication	replication	NN
cord-306904-8iteddug	175	23	and	and	CC
cord-306904-8iteddug	175	24	interference	interference	NN
cord-306904-8iteddug	175	25	with	with	IN
cord-306904-8iteddug	175	26	viral	viral	JJ
cord-306904-8iteddug	175	27	budding	budding	NN
cord-306904-8iteddug	175	28	/	/	SYM
cord-306904-8iteddug	175	29	release	release	NN
cord-306904-8iteddug	175	30	,	,	,
cord-306904-8iteddug	175	31	and	and	CC
cord-306904-8iteddug	175	32	disrupts	disrupt	VBZ
cord-306904-8iteddug	175	33	the	the	DT
cord-306904-8iteddug	175	34	actin	actin	NN
cord-306904-8iteddug	175	35	cytoskeleton	cytoskeleton	NN
cord-306904-8iteddug	175	36	to	to	TO
cord-306904-8iteddug	175	37	increase	increase	VB
cord-306904-8iteddug	175	38	infectivity	infectivity	NN
cord-306904-8iteddug	175	39	of	of	IN
cord-306904-8iteddug	175	40	human	human	JJ
cord-306904-8iteddug	175	41	cytomegalovirus	cytomegalovirus	NN
cord-306904-8iteddug	175	42	(	(	-LRB-
cord-306904-8iteddug	175	43	HCMV	HCMV	NNP
cord-306904-8iteddug	175	44	)	)	-RRB-
cord-306904-8iteddug	175	45	in	in	IN
cord-306904-8iteddug	175	46	a	a	DT
cord-306904-8iteddug	175	47	known	know	VBN
cord-306904-8iteddug	175	48	example	example	NN
cord-306904-8iteddug	175	49	of	of	IN
cord-306904-8iteddug	175	50	evolutionary	evolutionary	JJ
cord-306904-8iteddug	175	51	escape	escape	NN
cord-306904-8iteddug	175	52	of	of	IN
cord-306904-8iteddug	175	53	HCMV	HCMV	NNP
cord-306904-8iteddug	175	54	from	from	IN
cord-306904-8iteddug	175	55	the	the	DT
cord-306904-8iteddug	175	56	antiviral	antiviral	JJ
cord-306904-8iteddug	175	57	properties	property	NNS
cord-306904-8iteddug	175	58	of	of	IN
cord-306904-8iteddug	175	59	viperin	viperin	NNP
cord-306904-8iteddug	175	60	.	.	.
cord-306904-8iteddug	176	1	58	58	CD
cord-306904-8iteddug	176	2	Viperin	Viperin	NNP
cord-306904-8iteddug	176	3	is	be	VBZ
cord-306904-8iteddug	176	4	able	able	JJ
cord-306904-8iteddug	176	5	to	to	TO
cord-306904-8iteddug	176	6	interact	interact	VB
cord-306904-8iteddug	176	7	with	with	IN
cord-306904-8iteddug	176	8	the	the	DT
cord-306904-8iteddug	176	9	5	5	CD
cord-306904-8iteddug	176	10	host	host	NN
cord-306904-8iteddug	176	11	proteins	protein	NNS
cord-306904-8iteddug	176	12	FPPS	FPPS	NNP
cord-306904-8iteddug	176	13	,	,	,
cord-306904-8iteddug	176	14	TFP	tfp	NN
cord-306904-8iteddug	176	15	,	,	,
cord-306904-8iteddug	176	16	IRAK1	irak1	XX
cord-306904-8iteddug	176	17	,	,	,
cord-306904-8iteddug	176	18	VAP	VAP	NNP
cord-306904-8iteddug	176	19	-	-	HYPH
cord-306904-8iteddug	176	20	A	A	NNP
cord-306904-8iteddug	176	21	and	and	CC
cord-306904-8iteddug	176	22	TRAF6	traf6	NN
cord-306904-8iteddug	176	23	and	and	CC
cord-306904-8iteddug	176	24	the	the	DT
cord-306904-8iteddug	176	25	3	3	CD
cord-306904-8iteddug	176	26	viral	viral	JJ
cord-306904-8iteddug	176	27	proteins	protein	NNS
cord-306904-8iteddug	176	28	DENV	DENV	NNP
cord-306904-8iteddug	176	29	NS3	ns3	RB
cord-306904-8iteddug	176	30	,	,	,
cord-306904-8iteddug	176	31	HCV	HCV	NNP
cord-306904-8iteddug	176	32	NS5A	NS5A	NNP
cord-306904-8iteddug	176	33	and	and	CC
cord-306904-8iteddug	176	34	HCMV	HCMV	NNP
cord-306904-8iteddug	176	35	vMIA	vmia	NN
cord-306904-8iteddug	176	36	in	in	IN
cord-306904-8iteddug	176	37	order	order	NN
cord-306904-8iteddug	176	38	to	to	TO
cord-306904-8iteddug	176	39	accomplish	accomplish	VB
cord-306904-8iteddug	176	40	these	these	DT
cord-306904-8iteddug	176	41	diverse	diverse	JJ
cord-306904-8iteddug	176	42	biological	biological	JJ
cord-306904-8iteddug	176	43	functions	function	NNS
cord-306904-8iteddug	176	44	.	.	.
cord-306904-8iteddug	177	1	58	58	CD
cord-306904-8iteddug	177	2	Figure	figure	NN
cord-306904-8iteddug	177	3	6A	6a	NN
cord-306904-8iteddug	177	4	represents	represent	VBZ
cord-306904-8iteddug	177	5	the	the	DT
cord-306904-8iteddug	177	6	results	result	NNS
cord-306904-8iteddug	177	7	of	of	IN
cord-306904-8iteddug	177	8	the	the	DT
cord-306904-8iteddug	177	9	STRING	string	NN
cord-306904-8iteddug	177	10	59	59	CD
cord-306904-8iteddug	177	11	-based	-based	CD
cord-306904-8iteddug	177	12	evaluation	evaluation	NN
cord-306904-8iteddug	177	13	of	of	IN
cord-306904-8iteddug	177	14	viperin	viperin	NNP
cord-306904-8iteddug	177	15	interactivity	interactivity	NN
cord-306904-8iteddug	177	16	.	.	.
cord-306904-8iteddug	178	1	Although	although	IN
cord-306904-8iteddug	178	2	it	-PRON-	PRP
cord-306904-8iteddug	178	3	has	have	VBZ
cord-306904-8iteddug	178	4	been	be	VBN
cord-306904-8iteddug	178	5	emphasized	emphasize	VBN
cord-306904-8iteddug	178	6	that	that	IN
cord-306904-8iteddug	178	7	"	"	``
cord-306904-8iteddug	178	8	It	-PRON-	PRP
cord-306904-8iteddug	178	9	is	be	VBZ
cord-306904-8iteddug	178	10	unusual	unusual	JJ
cord-306904-8iteddug	178	11	for	for	IN
cord-306904-8iteddug	178	12	viperin	viperin	NNP
cord-306904-8iteddug	178	13	to	to	TO
cord-306904-8iteddug	178	14	be	be	VB
cord-306904-8iteddug	178	15	able	able	JJ
cord-306904-8iteddug	178	16	to	to	TO
cord-306904-8iteddug	178	17	interact	interact	VB
cord-306904-8iteddug	178	18	with	with	IN
cord-306904-8iteddug	178	19	such	such	PDT
cord-306904-8iteddug	178	20	a	a	DT
cord-306904-8iteddug	178	21	divergent	divergent	JJ
cord-306904-8iteddug	178	22	range	range	NN
cord-306904-8iteddug	178	23	of	of	IN
cord-306904-8iteddug	178	24	other	other	JJ
cord-306904-8iteddug	178	25	proteins	protein	NNS
cord-306904-8iteddug	178	26	and	and	CC
cord-306904-8iteddug	178	27	to	to	TO
cord-306904-8iteddug	178	28	potentially	potentially	RB
cord-306904-8iteddug	178	29	mediate	mediate	VB
cord-306904-8iteddug	178	30	quite	quite	RB
cord-306904-8iteddug	178	31	distinct	distinct	JJ
cord-306904-8iteddug	178	32	cellular	cellular	JJ
cord-306904-8iteddug	178	33	functions	function	NNS
cord-306904-8iteddug	178	34	"	"	''
cord-306904-8iteddug	178	35	,	,	,
cord-306904-8iteddug	178	36	58	58	CD
cord-306904-8iteddug	179	1	the	the	DT
cord-306904-8iteddug	179	2	mystery	mystery	NN
cord-306904-8iteddug	179	3	of	of	IN
cord-306904-8iteddug	179	4	such	such	JJ
cord-306904-8iteddug	179	5	"	"	``
cord-306904-8iteddug	179	6	unusual	unusual	JJ
cord-306904-8iteddug	179	7	"	"	''
cord-306904-8iteddug	179	8	polyfunctionality	polyfunctionality	NN
cord-306904-8iteddug	179	9	is	be	VBZ
cord-306904-8iteddug	179	10	naturally	naturally	RB
cord-306904-8iteddug	179	11	solved	solve	VBN
cord-306904-8iteddug	179	12	by	by	IN
cord-306904-8iteddug	179	13	the	the	DT
cord-306904-8iteddug	179	14	presence	presence	NN
cord-306904-8iteddug	179	15	of	of	IN
cord-306904-8iteddug	179	16	extensive	extensive	JJ
cord-306904-8iteddug	179	17	disorder	disorder	NN
cord-306904-8iteddug	179	18	in	in	IN
cord-306904-8iteddug	179	19	this	this	DT
cord-306904-8iteddug	179	20	protein	protein	NN
cord-306904-8iteddug	179	21	(	(	-LRB-
cord-306904-8iteddug	179	22	see	see	VB
cord-306904-8iteddug	179	23	Fig	Fig	NNP
cord-306904-8iteddug	179	24	.	.	.
cord-306904-8iteddug	180	1	6B	6b	NN
cord-306904-8iteddug	180	2	;	;	:
cord-306904-8iteddug	180	3	UniProt	UniProt	NNP
cord-306904-8iteddug	180	4	ID	ID	NNP
cord-306904-8iteddug	180	5	:	:	:
cord-306904-8iteddug	180	6	Q8WXG1	Q8WXG1	NNP
cord-306904-8iteddug	180	7	)	)	-RRB-
cord-306904-8iteddug	180	8	.	.	.
cord-306904-8iteddug	181	1	Sze	Sze	NNP
cord-306904-8iteddug	181	2	et	et	NNP
cord-306904-8iteddug	181	3	al	al	NNP
cord-306904-8iteddug	181	4	.	.	.
cord-306904-8iteddug	182	1	overviewed	overviewed	NNP
cord-306904-8iteddug	182	2	available	available	JJ
cord-306904-8iteddug	182	3	information	information	NN
cord-306904-8iteddug	182	4	on	on	IN
cord-306904-8iteddug	182	5	the	the	DT
cord-306904-8iteddug	182	6	sterile	sterile	JJ
cord-306904-8iteddug	182	7	a	a	DT
cord-306904-8iteddug	182	8	motif	motif	NN
cord-306904-8iteddug	182	9	and	and	CC
cord-306904-8iteddug	182	10	histidineaspartic	histidineaspartic	JJ
cord-306904-8iteddug	182	11	domain	domain	NN
cord-306904-8iteddug	182	12	(	(	-LRB-
cord-306904-8iteddug	182	13	HD	HD	NNP
cord-306904-8iteddug	182	14	)	)	-RRB-
cord-306904-8iteddug	182	15	containing	contain	VBG
cord-306904-8iteddug	182	16	protein	protein	NN
cord-306904-8iteddug	182	17	1	1	CD
cord-306904-8iteddug	182	18	(	(	-LRB-
cord-306904-8iteddug	182	19	SAMHD1	SAMHD1	NNPS
cord-306904-8iteddug	182	20	)	)	-RRB-
cord-306904-8iteddug	182	21	,	,	,
cord-306904-8iteddug	182	22	which	which	WDT
cord-306904-8iteddug	182	23	is	be	VBZ
cord-306904-8iteddug	182	24	a	a	DT
cord-306904-8iteddug	182	25	member	member	NN
cord-306904-8iteddug	182	26	of	of	IN
cord-306904-8iteddug	182	27	the	the	DT
cord-306904-8iteddug	182	28	unique	unique	JJ
cord-306904-8iteddug	182	29	group	group	NN
cord-306904-8iteddug	182	30	of	of	IN
cord-306904-8iteddug	182	31	host	host	NN
cord-306904-8iteddug	182	32	restriction	restriction	NN
cord-306904-8iteddug	182	33	factors	factor	NNS
cord-306904-8iteddug	182	34	that	that	WDT
cord-306904-8iteddug	182	35	limit	limit	VBP
cord-306904-8iteddug	182	36	retroviral	retroviral	NN
cord-306904-8iteddug	182	37	replication	replication	NN
cord-306904-8iteddug	182	38	at	at	IN
cord-306904-8iteddug	182	39	distinct	distinct	JJ
cord-306904-8iteddug	182	40	stages	stage	NNS
cord-306904-8iteddug	182	41	of	of	IN
cord-306904-8iteddug	182	42	the	the	DT
cord-306904-8iteddug	182	43	viral	viral	JJ
cord-306904-8iteddug	182	44	life	life	NN
cord-306904-8iteddug	182	45	cycle	cycle	NN
cord-306904-8iteddug	182	46	.	.	.
cord-306904-8iteddug	183	1	60	60	CD
cord-306904-8iteddug	183	2	SAMHD1	SAMHD1	NNPS
cord-306904-8iteddug	183	3	is	be	VBZ
cord-306904-8iteddug	183	4	a	a	DT
cord-306904-8iteddug	183	5	deoxynucleoside	deoxynucleoside	JJ
cord-306904-8iteddug	183	6	triphosphate	triphosphate	NN
cord-306904-8iteddug	183	7	triphosphohydrolase	triphosphohydrolase	NN
cord-306904-8iteddug	183	8	responsible	responsible	JJ
cord-306904-8iteddug	183	9	for	for	IN
cord-306904-8iteddug	183	10	the	the	DT
cord-306904-8iteddug	183	11	degradation	degradation	NN
cord-306904-8iteddug	183	12	of	of	IN
cord-306904-8iteddug	183	13	the	the	DT
cord-306904-8iteddug	183	14	deoxynucleoside	deoxynucleoside	NNP
cord-306904-8iteddug	183	15	triphosphates	triphosphates	NNP
cord-306904-8iteddug	183	16	(	(	-LRB-
cord-306904-8iteddug	183	17	dNTP	dntp	VBP
cord-306904-8iteddug	183	18	)	)	-RRB-
cord-306904-8iteddug	183	19	into	into	IN
cord-306904-8iteddug	183	20	their	-PRON-	PRP$
cord-306904-8iteddug	183	21	deoxynucleosides	deoxynucleoside	NNS
cord-306904-8iteddug	183	22	(	(	-LRB-
cord-306904-8iteddug	183	23	dN	dn	NN
cord-306904-8iteddug	183	24	)	)	-RRB-
cord-306904-8iteddug	183	25	and	and	CC
cord-306904-8iteddug	183	26	inorganic	inorganic	JJ
cord-306904-8iteddug	183	27	triphosphates	triphosphate	NNS
cord-306904-8iteddug	183	28	,	,	,
cord-306904-8iteddug	183	29	thus	thus	RB
cord-306904-8iteddug	183	30	depleting	deplete	VBG
cord-306904-8iteddug	183	31	the	the	DT
cord-306904-8iteddug	183	32	cellular	cellular	JJ
cord-306904-8iteddug	183	33	dNTP	dNTP	NNP
cord-306904-8iteddug	183	34	pool	pool	NN
cord-306904-8iteddug	183	35	required	require	VBN
cord-306904-8iteddug	183	36	for	for	IN
cord-306904-8iteddug	183	37	cellular	cellular	JJ
cord-306904-8iteddug	183	38	DNA	dna	NN
cord-306904-8iteddug	183	39	polymerase	polymerase	NN
cord-306904-8iteddug	183	40	.	.	.
cord-306904-8iteddug	184	1	61	61	CD
cord-306904-8iteddug	184	2	Activity	activity	NN
cord-306904-8iteddug	184	3	of	of	IN
cord-306904-8iteddug	184	4	this	this	DT
cord-306904-8iteddug	184	5	protein	protein	NN
cord-306904-8iteddug	184	6	is	be	VBZ
cord-306904-8iteddug	184	7	modulated	modulate	VBN
cord-306904-8iteddug	184	8	by	by	IN
cord-306904-8iteddug	184	9	post	post	JJ
cord-306904-8iteddug	184	10	-	-	JJ
cord-306904-8iteddug	184	11	translational	translational	JJ
cord-306904-8iteddug	184	12	modifications	modification	NNS
cord-306904-8iteddug	184	13	,	,	,
cord-306904-8iteddug	184	14	cell	cell	NN
cord-306904-8iteddug	184	15	-	-	HYPH
cord-306904-8iteddug	184	16	cycle	cycle	NN
cord-306904-8iteddug	184	17	-	-	HYPH
cord-306904-8iteddug	184	18	dependent	dependent	JJ
cord-306904-8iteddug	184	19	functions	function	NNS
cord-306904-8iteddug	184	20	and	and	CC
cord-306904-8iteddug	184	21	cytokine	cytokine	NN
cord-306904-8iteddug	184	22	-	-	HYPH
cord-306904-8iteddug	184	23	mediated	mediate	VBN
cord-306904-8iteddug	184	24	changes	change	NNS
cord-306904-8iteddug	184	25	,	,	,
cord-306904-8iteddug	184	26	as	as	RB
cord-306904-8iteddug	184	27	well	well	RB
cord-306904-8iteddug	184	28	as	as	IN
cord-306904-8iteddug	184	29	via	via	IN
cord-306904-8iteddug	184	30	interaction	interaction	NN
cord-306904-8iteddug	184	31	with	with	IN
cord-306904-8iteddug	184	32	the	the	DT
cord-306904-8iteddug	184	33	Vpx	Vpx	NNP
cord-306904-8iteddug	184	34	accessory	accessory	NN
cord-306904-8iteddug	184	35	protein	protein	NN
cord-306904-8iteddug	184	36	.	.	.
cord-306904-8iteddug	185	1	60	60	CD
cord-306904-8iteddug	185	2	SAMHD1is	samhd1i	NNS
cord-306904-8iteddug	185	3	a	a	DT
cord-306904-8iteddug	185	4	predominantly	predominantly	RB
cord-306904-8iteddug	185	5	nuclear	nuclear	JJ
cord-306904-8iteddug	185	6	protein	protein	NN
cord-306904-8iteddug	185	7	composed	compose	VBN
cord-306904-8iteddug	185	8	of	of	IN
cord-306904-8iteddug	185	9	2	2	CD
cord-306904-8iteddug	185	10	functional	functional	JJ
cord-306904-8iteddug	185	11	domains	domain	NNS
cord-306904-8iteddug	185	12	,	,	,
cord-306904-8iteddug	185	13	the	the	DT
cord-306904-8iteddug	185	14	sterile	sterile	JJ
cord-306904-8iteddug	185	15	a	a	DT
cord-306904-8iteddug	185	16	motif	motif	NN
cord-306904-8iteddug	185	17	(	(	-LRB-
cord-306904-8iteddug	185	18	SAM	SAM	NNP
cord-306904-8iteddug	185	19	)	)	-RRB-
cord-306904-8iteddug	185	20	domain	domain	NN
cord-306904-8iteddug	185	21	involved	involve	VBN
cord-306904-8iteddug	185	22	in	in	IN
cord-306904-8iteddug	185	23	protein	protein	NN
cord-306904-8iteddug	185	24	-	-	HYPH
cord-306904-8iteddug	185	25	protein	protein	NN
cord-306904-8iteddug	185	26	and	and	CC
cord-306904-8iteddug	185	27	SAMHD1-nucleic	SAMHD1-nucleic	NNP
cord-306904-8iteddug	185	28	acid	acid	JJ
cord-306904-8iteddug	185	29	interactions	interaction	NNS
cord-306904-8iteddug	185	30	,	,	,
cord-306904-8iteddug	185	31	62	62	CD
cord-306904-8iteddug	185	32	and	and	CC
cord-306904-8iteddug	185	33	the	the	DT
cord-306904-8iteddug	185	34	HD	hd	NN
cord-306904-8iteddug	185	35	domain	domain	NN
cord-306904-8iteddug	185	36	containing	contain	VBG
cord-306904-8iteddug	185	37	the	the	DT
cord-306904-8iteddug	185	38	enzymatic	enzymatic	JJ
cord-306904-8iteddug	185	39	sites	site	NNS
cord-306904-8iteddug	185	40	crucial	crucial	JJ
cord-306904-8iteddug	185	41	for	for	IN
cord-306904-8iteddug	185	42	its	-PRON-	PRP$
cord-306904-8iteddug	185	43	triphosphohydrolase	triphosphohydrolase	NN
cord-306904-8iteddug	185	44	activity	activity	NN
cord-306904-8iteddug	185	45	,	,	,
cord-306904-8iteddug	185	46	RNA	RNA	NNP
cord-306904-8iteddug	185	47	binding	binding	NN
cord-306904-8iteddug	185	48	and	and	CC
cord-306904-8iteddug	185	49	nuclease	nuclease	NN
cord-306904-8iteddug	185	50	activity	activity	NN
cord-306904-8iteddug	185	51	.	.	.
cord-306904-8iteddug	186	1	63	63	CD
cord-306904-8iteddug	187	1	Another	another	DT
cord-306904-8iteddug	187	2	functionally	functionally	RB
cord-306904-8iteddug	187	3	important	important	JJ
cord-306904-8iteddug	187	4	region	region	NN
cord-306904-8iteddug	187	5	is	be	VBZ
cord-306904-8iteddug	187	6	located	locate	VBN
cord-306904-8iteddug	187	7	at	at	IN
cord-306904-8iteddug	187	8	the	the	DT
cord-306904-8iteddug	187	9	C	C	NNP
cord-306904-8iteddug	187	10	-	-	HYPH
cord-306904-8iteddug	187	11	terminus	terminus	NN
cord-306904-8iteddug	187	12	of	of	IN
cord-306904-8iteddug	187	13	SAMHD1	SAMHD1	NNS
cord-306904-8iteddug	187	14	,	,	,
cord-306904-8iteddug	187	15	where	where	WRB
cord-306904-8iteddug	187	16	a	a	DT
cord-306904-8iteddug	187	17	V	v	NN
cord-306904-8iteddug	187	18	-	-	NN
cord-306904-8iteddug	187	19	domain	domain	NN
cord-306904-8iteddug	187	20	capable	capable	JJ
cord-306904-8iteddug	187	21	of	of	IN
cord-306904-8iteddug	187	22	interaction	interaction	NN
cord-306904-8iteddug	187	23	with	with	IN
cord-306904-8iteddug	187	24	the	the	DT
cord-306904-8iteddug	187	25	HIV-2/	hiv-2/	NN
cord-306904-8iteddug	188	1	SIVsm	SIVsm	NNP
cord-306904-8iteddug	188	2	Vpx	Vpx	NNP
cord-306904-8iteddug	188	3	accessory	accessory	NN
cord-306904-8iteddug	188	4	protein	protein	NN
cord-306904-8iteddug	188	5	is	be	VBZ
cord-306904-8iteddug	188	6	located	locate	VBN
cord-306904-8iteddug	188	7	(	(	-LRB-
cord-306904-8iteddug	188	8	residues	residue	NNS
cord-306904-8iteddug	188	9	595	595	CD
cord-306904-8iteddug	188	10	-	-	SYM
cord-306904-8iteddug	188	11	626	626	CD
cord-306904-8iteddug	188	12	)	)	-RRB-
cord-306904-8iteddug	188	13	.	.	.
cord-306904-8iteddug	189	1	64	64	CD
cord-306904-8iteddug	190	1	Based	base	VBN
cord-306904-8iteddug	190	2	on	on	IN
cord-306904-8iteddug	190	3	the	the	DT
cord-306904-8iteddug	190	4	intrinsic	intrinsic	JJ
cord-306904-8iteddug	190	5	disorder	disorder	NN
cord-306904-8iteddug	190	6	propensity	propensity	NN
cord-306904-8iteddug	190	7	analysis	analysis	NN
cord-306904-8iteddug	190	8	(	(	-LRB-
cord-306904-8iteddug	190	9	Fig	Fig	NNP
cord-306904-8iteddug	190	10	.	.	.
cord-306904-8iteddug	190	11	2B	2B	NNP
cord-306904-8iteddug	190	12	)	)	-RRB-
cord-306904-8iteddug	190	13	,	,	,
cord-306904-8iteddug	190	14	SAMHD1	SAMHD1	NNPS
cord-306904-8iteddug	191	1	(	(	-LRB-
cord-306904-8iteddug	191	2	UniProt	UniProt	NNP
cord-306904-8iteddug	191	3	ID	ID	NNP
cord-306904-8iteddug	191	4	:	:	:
cord-306904-8iteddug	192	1	Q9Y3Z3	Q9Y3Z3	NNP
cord-306904-8iteddug	192	2	)	)	-RRB-
cord-306904-8iteddug	192	3	is	be	VBZ
cord-306904-8iteddug	192	4	expected	expect	VBN
cord-306904-8iteddug	192	5	to	to	TO
cord-306904-8iteddug	192	6	be	be	VB
cord-306904-8iteddug	192	7	a	a	DT
cord-306904-8iteddug	192	8	predominantly	predominantly	RB
cord-306904-8iteddug	192	9	ordered	order	VBN
cord-306904-8iteddug	192	10	protein	protein	NN
cord-306904-8iteddug	192	11	possessing	possess	VBG
cord-306904-8iteddug	192	12	disordered	disordered	JJ
cord-306904-8iteddug	192	13	N	N	NNP
cord-306904-8iteddug	192	14	-	-	HYPH
cord-306904-8iteddug	192	15	and	and	CC
cord-306904-8iteddug	192	16	C	c	NN
cord-306904-8iteddug	192	17	-	-	HYPH
cord-306904-8iteddug	192	18	terminal	terminal	NN
cord-306904-8iteddug	192	19	tails	tail	NNS
cord-306904-8iteddug	192	20	(	(	-LRB-
cord-306904-8iteddug	192	21	residues	residue	NNS
cord-306904-8iteddug	192	22	1	1	CD
cord-306904-8iteddug	192	23	-	-	SYM
cord-306904-8iteddug	192	24	100	100	CD
cord-306904-8iteddug	192	25	and	and	CC
cord-306904-8iteddug	192	26	580	580	CD
cord-306904-8iteddug	192	27	-	-	HYPH
cord-306904-8iteddug	192	28	626	626	CD
cord-306904-8iteddug	192	29	)	)	-RRB-
cord-306904-8iteddug	192	30	.	.	.
cord-306904-8iteddug	193	1	Obviously	obviously	RB
cord-306904-8iteddug	193	2	,	,	,
cord-306904-8iteddug	193	3	intrinsic	intrinsic	JJ
cord-306904-8iteddug	193	4	disorder	disorder	NN
cord-306904-8iteddug	193	5	in	in	IN
cord-306904-8iteddug	193	6	the	the	DT
cord-306904-8iteddug	193	7	C	c	NN
cord-306904-8iteddug	193	8	-	-	HYPH
cord-306904-8iteddug	193	9	terminal	terminal	NN
cord-306904-8iteddug	193	10	tail	tail	NN
cord-306904-8iteddug	193	11	is	be	VBZ
cord-306904-8iteddug	193	12	important	important	JJ
cord-306904-8iteddug	193	13	for	for	IN
cord-306904-8iteddug	193	14	the	the	DT
cord-306904-8iteddug	193	15	SAMHD1	SAMHD1	NNPS
cord-306904-8iteddug	193	16	interaction	interaction	NN
cord-306904-8iteddug	193	17	with	with	IN
cord-306904-8iteddug	193	18	the	the	DT
cord-306904-8iteddug	193	19	HIV-2	HIV-2	NNP
cord-306904-8iteddug	193	20	/	/	SYM
cord-306904-8iteddug	193	21	SIVsm	SIVsm	NNP
cord-306904-8iteddug	193	22	Vpx	Vpx	NNP
cord-306904-8iteddug	193	23	accessory	accessory	NN
cord-306904-8iteddug	193	24	protein	protein	NN
cord-306904-8iteddug	193	25	.	.	.
cord-306904-8iteddug	194	1	Interaction	interaction	NN
cord-306904-8iteddug	194	2	between	between	IN
cord-306904-8iteddug	194	3	the	the	DT
cord-306904-8iteddug	194	4	major	major	JJ
cord-306904-8iteddug	194	5	bacterial	bacterial	JJ
cord-306904-8iteddug	194	6	heat	heat	NN
cord-306904-8iteddug	194	7	shock	shock	NN
cord-306904-8iteddug	194	8	chaperone	chaperone	NN
cord-306904-8iteddug	194	9	GroESL	GroESL	NNP
cord-306904-8iteddug	194	10	and	and	CC
cord-306904-8iteddug	194	11	an	an	DT
cord-306904-8iteddug	194	12	RNA	RNA	NNP
cord-306904-8iteddug	194	13	chaperone	chaperone	NN
cord-306904-8iteddug	194	14	CspC	CspC	NNP
cord-306904-8iteddug	195	1	In	in	IN
cord-306904-8iteddug	195	2	their	-PRON-	PRP$
cord-306904-8iteddug	195	3	recent	recent	JJ
cord-306904-8iteddug	195	4	paper	paper	NN
cord-306904-8iteddug	195	5	,	,	,
cord-306904-8iteddug	195	6	Lenz	Lenz	NNP
cord-306904-8iteddug	195	7	&	&	CC
cord-306904-8iteddug	195	8	Ron	Ron	NNP
cord-306904-8iteddug	195	9	described	describe	VBD
cord-306904-8iteddug	195	10	a	a	DT
cord-306904-8iteddug	195	11	novel	novel	JJ
cord-306904-8iteddug	195	12	interaction	interaction	NN
cord-306904-8iteddug	195	13	between	between	IN
cord-306904-8iteddug	195	14	the	the	DT
cord-306904-8iteddug	195	15	major	major	JJ
cord-306904-8iteddug	195	16	heat	heat	NN
cord-306904-8iteddug	195	17	shock	shock	NN
cord-306904-8iteddug	195	18	chaperone	chaperone	NN
cord-306904-8iteddug	195	19	GroESL	GroESL	NNP
cord-306904-8iteddug	195	20	of	of	IN
cord-306904-8iteddug	195	21	E.	E.	NNP
cord-306904-8iteddug	195	22	coli	coli	NNS
cord-306904-8iteddug	195	23	(	(	-LRB-
cord-306904-8iteddug	195	24	Hsp60	Hsp60	NNP
cord-306904-8iteddug	195	25	)	)	-RRB-
cord-306904-8iteddug	195	26	with	with	IN
cord-306904-8iteddug	195	27	an	an	DT
cord-306904-8iteddug	195	28	RNA	RNA	NNP
cord-306904-8iteddug	195	29	chaperone	chaperone	NN
cord-306904-8iteddug	195	30	(	(	-LRB-
cord-306904-8iteddug	195	31	CspC	CspC	NNP
cord-306904-8iteddug	195	32	)	)	-RRB-
cord-306904-8iteddug	195	33	leading	lead	VBG
cord-306904-8iteddug	195	34	to	to	IN
cord-306904-8iteddug	195	35	the	the	DT
cord-306904-8iteddug	195	36	CspC	CspC	NNP
cord-306904-8iteddug	195	37	proteolysis	proteolysis	NN
cord-306904-8iteddug	195	38	needed	need	VBN
cord-306904-8iteddug	195	39	for	for	IN
cord-306904-8iteddug	195	40	the	the	DT
cord-306904-8iteddug	195	41	transient	transient	JJ
cord-306904-8iteddug	195	42	nature	nature	NN
cord-306904-8iteddug	195	43	of	of	IN
cord-306904-8iteddug	195	44	the	the	DT
cord-306904-8iteddug	195	45	heat	heat	NN
cord-306904-8iteddug	195	46	shock	shock	NN
cord-306904-8iteddug	195	47	response	response	NN
cord-306904-8iteddug	195	48	.	.	.
cord-306904-8iteddug	196	1	65	65	CD
cord-306904-8iteddug	196	2	Protein	protein	NN
cord-306904-8iteddug	196	3	chaperones	chaperone	NNS
cord-306904-8iteddug	196	4	and	and	CC
cord-306904-8iteddug	196	5	proteases	protease	NNS
cord-306904-8iteddug	196	6	have	have	VBP
cord-306904-8iteddug	196	7	multiple	multiple	JJ
cord-306904-8iteddug	196	8	functions	function	NNS
cord-306904-8iteddug	196	9	in	in	IN
cord-306904-8iteddug	196	10	controlling	control	VBG
cord-306904-8iteddug	196	11	the	the	DT
cord-306904-8iteddug	196	12	wellbeing	wellbeing	NN
cord-306904-8iteddug	196	13	of	of	IN
cord-306904-8iteddug	196	14	a	a	DT
cord-306904-8iteddug	196	15	cell	cell	NN
cord-306904-8iteddug	196	16	,	,	,
cord-306904-8iteddug	196	17	acting	act	VBG
cord-306904-8iteddug	196	18	as	as	IN
cord-306904-8iteddug	196	19	protein	protein	NN
cord-306904-8iteddug	196	20	quality	quality	NN
cord-306904-8iteddug	196	21	control	control	NN
cord-306904-8iteddug	196	22	that	that	WDT
cord-306904-8iteddug	196	23	enables	enable	VBZ
cord-306904-8iteddug	196	24	the	the	DT
cord-306904-8iteddug	196	25	cells	cell	NNS
cord-306904-8iteddug	196	26	to	to	TO
cord-306904-8iteddug	196	27	cope	cope	VB
cord-306904-8iteddug	196	28	with	with	IN
cord-306904-8iteddug	196	29	the	the	DT
cord-306904-8iteddug	196	30	unfolding	unfold	VBG
cord-306904-8iteddug	196	31	and	and	CC
cord-306904-8iteddug	196	32	aggregation	aggregation	NN
cord-306904-8iteddug	196	33	of	of	IN
cord-306904-8iteddug	196	34	proteins	protein	NNS
cord-306904-8iteddug	196	35	.	.	.
cord-306904-8iteddug	197	1	66	66	CD
cord-306904-8iteddug	198	1	,	,	,
cord-306904-8iteddug	198	2	67	67	CD
cord-306904-8iteddug	198	3	CspC	CspC	NNP
cord-306904-8iteddug	198	4	is	be	VBZ
cord-306904-8iteddug	198	5	a	a	DT
cord-306904-8iteddug	198	6	member	member	NN
cord-306904-8iteddug	198	7	of	of	IN
cord-306904-8iteddug	198	8	the	the	DT
cord-306904-8iteddug	198	9	cold	cold	JJ
cord-306904-8iteddug	198	10	shock	shock	NN
cord-306904-8iteddug	198	11	protein	protein	NN
cord-306904-8iteddug	198	12	(	(	-LRB-
cord-306904-8iteddug	198	13	Csp	Csp	NNP
cord-306904-8iteddug	198	14	)	)	-RRB-
cord-306904-8iteddug	198	15	family	family	NN
cord-306904-8iteddug	198	16	that	that	WDT
cord-306904-8iteddug	198	17	consists	consist	VBZ
cord-306904-8iteddug	198	18	of	of	IN
cord-306904-8iteddug	198	19	7	7	CD
cord-306904-8iteddug	198	20	small	small	JJ
cord-306904-8iteddug	198	21	homologues	homologue	NNS
cord-306904-8iteddug	198	22	with	with	IN
cord-306904-8iteddug	198	23	high	high	JJ
cord-306904-8iteddug	198	24	affinity	affinity	NN
cord-306904-8iteddug	198	25	to	to	IN
cord-306904-8iteddug	198	26	single	single	JJ
cord-306904-8iteddug	198	27	-	-	HYPH
cord-306904-8iteddug	198	28	strand	strand	NN
cord-306904-8iteddug	198	29	nucleic	nucleic	JJ
cord-306904-8iteddug	198	30	acid	acid	NN
cord-306904-8iteddug	198	31	and	and	CC
cord-306904-8iteddug	198	32	that	that	WDT
cord-306904-8iteddug	198	33	serve	serve	VBP
cord-306904-8iteddug	198	34	as	as	IN
cord-306904-8iteddug	198	35	RNA	RNA	NNP
cord-306904-8iteddug	198	36	chaperones	chaperone	NNS
cord-306904-8iteddug	198	37	.	.	.
cord-306904-8iteddug	199	1	[	[	-LRB-
cord-306904-8iteddug	199	2	68	68	CD
cord-306904-8iteddug	199	3	]	]	-RRB-
cord-306904-8iteddug	199	4	[	[	-LRB-
cord-306904-8iteddug	199	5	69	69	CD
cord-306904-8iteddug	199	6	]	]	-RRB-
cord-306904-8iteddug	199	7	[	[	-LRB-
cord-306904-8iteddug	199	8	70	70	CD
cord-306904-8iteddug	199	9	]	]	-RRB-
cord-306904-8iteddug	200	1	[	[	-LRB-
cord-306904-8iteddug	200	2	71	71	CD
cord-306904-8iteddug	200	3	]	]	-RRB-
cord-306904-8iteddug	201	1	It	-PRON-	PRP
cord-306904-8iteddug	201	2	has	have	VBZ
cord-306904-8iteddug	201	3	been	be	VBN
cord-306904-8iteddug	201	4	shown	show	VBN
cord-306904-8iteddug	201	5	that	that	IN
cord-306904-8iteddug	201	6	CspC	CspC	NNP
cord-306904-8iteddug	201	7	is	be	VBZ
cord-306904-8iteddug	201	8	degraded	degrade	VBN
cord-306904-8iteddug	201	9	during	during	IN
cord-306904-8iteddug	201	10	heat	heat	NN
cord-306904-8iteddug	201	11	shock	shock	NN
cord-306904-8iteddug	201	12	and	and	CC
cord-306904-8iteddug	201	13	that	that	IN
cord-306904-8iteddug	201	14	interaction	interaction	NN
cord-306904-8iteddug	201	15	of	of	IN
cord-306904-8iteddug	201	16	CspC	CspC	NNP
cord-306904-8iteddug	201	17	with	with	IN
cord-306904-8iteddug	201	18	the	the	DT
cord-306904-8iteddug	201	19	major	major	JJ
cord-306904-8iteddug	201	20	protein	protein	NN
cord-306904-8iteddug	201	21	chaperone	chaperone	NN
cord-306904-8iteddug	202	1	GroESL	GroESL	NNP
cord-306904-8iteddug	202	2	plays	play	VBZ
cord-306904-8iteddug	202	3	a	a	DT
cord-306904-8iteddug	202	4	role	role	NN
cord-306904-8iteddug	202	5	in	in	IN
cord-306904-8iteddug	202	6	the	the	DT
cord-306904-8iteddug	202	7	enhanced	enhanced	JJ
cord-306904-8iteddug	202	8	,	,	,
cord-306904-8iteddug	202	9	temperature	temperature	NN
cord-306904-8iteddug	202	10	-	-	HYPH
cord-306904-8iteddug	202	11	dependent	dependent	JJ
cord-306904-8iteddug	202	12	proteolysis	proteolysis	NN
cord-306904-8iteddug	202	13	of	of	IN
cord-306904-8iteddug	202	14	CspC.	CspC.	.
cord-306904-8iteddug	203	1	65	65	CD
cord-306904-8iteddug	204	1	The	the	DT
cord-306904-8iteddug	204	2	fact	fact	NN
cord-306904-8iteddug	204	3	that	that	IN
cord-306904-8iteddug	204	4	CspC	CspC	NNP
cord-306904-8iteddug	204	5	is	be	VBZ
cord-306904-8iteddug	204	6	able	able	JJ
cord-306904-8iteddug	204	7	to	to	TO
cord-306904-8iteddug	204	8	interact	interact	VB
cord-306904-8iteddug	204	9	with	with	IN
cord-306904-8iteddug	204	10	GroESL	GroESL	NNP
cord-306904-8iteddug	204	11	(	(	-LRB-
cord-306904-8iteddug	204	12	which	which	WDT
cord-306904-8iteddug	204	13	is	be	VBZ
cord-306904-8iteddug	204	14	known	know	VBN
cord-306904-8iteddug	204	15	to	to	TO
cord-306904-8iteddug	204	16	bind	bind	VB
cord-306904-8iteddug	204	17	partially	partially	RB
cord-306904-8iteddug	204	18	unfolded	unfold	VBN
cord-306904-8iteddug	204	19	and	and	CC
cord-306904-8iteddug	204	20	misfolded	misfolde	VBN
cord-306904-8iteddug	204	21	protein	protein	NN
cord-306904-8iteddug	204	22	species	specie	NNS
cord-306904-8iteddug	204	23	)	)	-RRB-
cord-306904-8iteddug	204	24	is	be	VBZ
cord-306904-8iteddug	204	25	a	a	DT
cord-306904-8iteddug	204	26	clear	clear	JJ
cord-306904-8iteddug	204	27	indication	indication	NN
cord-306904-8iteddug	204	28	that	that	IN
cord-306904-8iteddug	204	29	CspC	CspC	NNP
cord-306904-8iteddug	204	30	does	do	VBZ
cord-306904-8iteddug	204	31	not	not	RB
cord-306904-8iteddug	204	32	possess	possess	VB
cord-306904-8iteddug	204	33	rigid	rigid	JJ
cord-306904-8iteddug	204	34	structure	structure	NN
cord-306904-8iteddug	204	35	,	,	,
cord-306904-8iteddug	204	36	at	at	IN
cord-306904-8iteddug	204	37	least	least	JJS
cord-306904-8iteddug	204	38	under	under	IN
cord-306904-8iteddug	204	39	the	the	DT
cord-306904-8iteddug	204	40	conditions	condition	NNS
cord-306904-8iteddug	204	41	favoring	favor	VBG
cord-306904-8iteddug	204	42	such	such	JJ
cord-306904-8iteddug	204	43	interaction	interaction	NN
cord-306904-8iteddug	204	44	.	.	.
cord-306904-8iteddug	205	1	The	the	DT
cord-306904-8iteddug	205	2	likely	likely	JJ
cord-306904-8iteddug	205	3	explanation	explanation	NN
cord-306904-8iteddug	205	4	for	for	IN
cord-306904-8iteddug	205	5	this	this	DT
cord-306904-8iteddug	205	6	binding	binding	NN
cord-306904-8iteddug	205	7	is	be	VBZ
cord-306904-8iteddug	205	8	in	in	IN
cord-306904-8iteddug	205	9	the	the	DT
cord-306904-8iteddug	205	10	potential	potential	NN
cord-306904-8iteddug	205	11	intrinsically	intrinsically	RB
cord-306904-8iteddug	205	12	disordered	disordered	JJ
cord-306904-8iteddug	205	13	nature	nature	NN
cord-306904-8iteddug	205	14	of	of	IN
cord-306904-8iteddug	205	15	CspC.	CspC.	.
cord-306904-8iteddug	206	1	In	in	IN
cord-306904-8iteddug	206	2	fact	fact	NN
cord-306904-8iteddug	206	3	,	,	,
cord-306904-8iteddug	206	4	many	many	JJ
cord-306904-8iteddug	206	5	protein	protein	NN
cord-306904-8iteddug	206	6	and	and	CC
cord-306904-8iteddug	206	7	RNA	RNA	NNP
cord-306904-8iteddug	206	8	chaperones	chaperone	NNS
cord-306904-8iteddug	206	9	were	be	VBD
cord-306904-8iteddug	206	10	shown	show	VBN
cord-306904-8iteddug	206	11	to	to	TO
cord-306904-8iteddug	206	12	be	be	VB
cord-306904-8iteddug	206	13	intrinsically	intrinsically	RB
cord-306904-8iteddug	206	14	disordered	disordered	JJ
cord-306904-8iteddug	206	15	or	or	CC
cord-306904-8iteddug	206	16	hybrid	hybrid	JJ
cord-306904-8iteddug	206	17	proteins	protein	NNS
cord-306904-8iteddug	206	18	possessing	possess	VBG
cord-306904-8iteddug	206	19	both	both	CC
cord-306904-8iteddug	206	20	ordered	order	VBN
cord-306904-8iteddug	206	21	and	and	CC
cord-306904-8iteddug	206	22	intrinsically	intrinsically	RB
cord-306904-8iteddug	206	23	disordered	disordered	JJ
cord-306904-8iteddug	206	24	regions/	regions/	CD
cord-306904-8iteddug	206	25	domains	domain	NNS
cord-306904-8iteddug	206	26	.	.	.
cord-306904-8iteddug	207	1	72	72	CD
cord-306904-8iteddug	208	1	In	in	IN
cord-306904-8iteddug	208	2	agreement	agreement	NN
cord-306904-8iteddug	208	3	with	with	IN
cord-306904-8iteddug	208	4	this	this	DT
cord-306904-8iteddug	208	5	observation	observation	NN
cord-306904-8iteddug	208	6	,	,	,
cord-306904-8iteddug	208	7	Figure	figure	NN
cord-306904-8iteddug	208	8	2C	2c	NN
cord-306904-8iteddug	208	9	represents	represent	VBZ
cord-306904-8iteddug	208	10	the	the	DT
cord-306904-8iteddug	208	11	PONDR	PONDR	NNP
cord-306904-8iteddug	208	12	plots	plot	NNS
cord-306904-8iteddug	208	13	for	for	IN
cord-306904-8iteddug	208	14	the	the	DT
cord-306904-8iteddug	208	15	CspC	CspC	NNP
cord-306904-8iteddug	208	16	from	from	IN
cord-306904-8iteddug	208	17	E.	E.	NNP
cord-306904-8iteddug	208	18	coli	coli	NNS
cord-306904-8iteddug	208	19	(	(	-LRB-
cord-306904-8iteddug	208	20	UniProt	UniProt	NNP
cord-306904-8iteddug	208	21	ID	ID	NNP
cord-306904-8iteddug	208	22	:	:	:
cord-306904-8iteddug	208	23	P0A9Y6	p0a9y6	NN
cord-306904-8iteddug	208	24	)	)	-RRB-
cord-306904-8iteddug	208	25	and	and	CC
cord-306904-8iteddug	208	26	shows	show	VBZ
cord-306904-8iteddug	208	27	that	that	IN
cord-306904-8iteddug	208	28	a	a	DT
cord-306904-8iteddug	208	29	significant	significant	JJ
cord-306904-8iteddug	208	30	portion	portion	NN
cord-306904-8iteddug	208	31	of	of	IN
cord-306904-8iteddug	208	32	this	this	DT
cord-306904-8iteddug	208	33	small	small	JJ
cord-306904-8iteddug	208	34	proteins	protein	NNS
cord-306904-8iteddug	208	35	(	(	-LRB-
cord-306904-8iteddug	208	36	up	up	IN
cord-306904-8iteddug	208	37	to	to	TO
cord-306904-8iteddug	208	38	35	35	CD
cord-306904-8iteddug	208	39	%	%	NN
cord-306904-8iteddug	208	40	)	)	-RRB-
cord-306904-8iteddug	208	41	is	be	VBZ
cord-306904-8iteddug	208	42	predicted	predict	VBN
cord-306904-8iteddug	208	43	to	to	TO
cord-306904-8iteddug	208	44	be	be	VB
cord-306904-8iteddug	208	45	disordered	disordered	JJ
cord-306904-8iteddug	208	46	.	.	.
cord-306904-8iteddug	209	1	Kalli	Kalli	NNP
cord-306904-8iteddug	209	2	et	et	NNP
cord-306904-8iteddug	209	3	al	al	NNP
cord-306904-8iteddug	209	4	.	.	.
cord-306904-8iteddug	210	1	used	use	VBN
cord-306904-8iteddug	210	2	multiscale	multiscale	JJ
cord-306904-8iteddug	210	3	molecular	molecular	JJ
cord-306904-8iteddug	210	4	dynamics	dynamic	NNS
cord-306904-8iteddug	210	5	simulations	simulation	NNS
cord-306904-8iteddug	210	6	to	to	TO
cord-306904-8iteddug	210	7	define	define	VB
cord-306904-8iteddug	210	8	the	the	DT
cord-306904-8iteddug	210	9	interaction	interaction	NN
cord-306904-8iteddug	210	10	mechanisms	mechanism	NNS
cord-306904-8iteddug	210	11	of	of	IN
cord-306904-8iteddug	210	12	phosphatase	phosphatase	NN
cord-306904-8iteddug	210	13	and	and	CC
cord-306904-8iteddug	210	14	tensin	tensin	NNP
cord-306904-8iteddug	210	15	homolog	homolog	NN
cord-306904-8iteddug	210	16	(	(	-LRB-
cord-306904-8iteddug	210	17	PTEN	PTEN	NNP
cord-306904-8iteddug	210	18	;	;	:
cord-306904-8iteddug	210	19	UniProt	UniProt	NNP
cord-306904-8iteddug	210	20	ID	ID	NNP
cord-306904-8iteddug	210	21	:	:	:
cord-306904-8iteddug	211	1	P60484	P60484	NNP
cord-306904-8iteddug	211	2	)	)	-RRB-
cord-306904-8iteddug	211	3	and	and	CC
cord-306904-8iteddug	211	4	of	of	IN
cord-306904-8iteddug	211	5	the	the	DT
cord-306904-8iteddug	211	6	PTEN	PTEN	NNP
cord-306904-8iteddug	211	7	domain	domain	NN
cord-306904-8iteddug	211	8	of	of	IN
cord-306904-8iteddug	211	9	Ciona	Ciona	NNP
cord-306904-8iteddug	211	10	intestinalis	intestinalis	NNP
cord-306904-8iteddug	211	11	voltage	voltage	VBP
cord-306904-8iteddug	211	12	sensitive	sensitive	JJ
cord-306904-8iteddug	211	13	phosphatase	phosphatase	NN
cord-306904-8iteddug	211	14	(	(	-LRB-
cord-306904-8iteddug	211	15	Ci	Ci	NNP
cord-306904-8iteddug	211	16	-	-	HYPH
cord-306904-8iteddug	211	17	VSP	VSP	NNP
cord-306904-8iteddug	211	18	;	;	:
cord-306904-8iteddug	211	19	UniProt	UniProt	NNP
cord-306904-8iteddug	211	20	ID	ID	NNP
cord-306904-8iteddug	211	21	:	:	:
cord-306904-8iteddug	211	22	Q4W8A1	Q4W8A1	NNP
cord-306904-8iteddug	211	23	)	)	-RRB-
cord-306904-8iteddug	211	24	with	with	IN
cord-306904-8iteddug	211	25	phosphatidylinositol	phosphatidylinositol	JJ
cord-306904-8iteddug	211	26	phosphate	phosphate	NN
cord-306904-8iteddug	211	27	(	(	-LRB-
cord-306904-8iteddug	211	28	PIP)-containing	pip)-containe	VBG
cord-306904-8iteddug	211	29	lipid	lipid	NN
cord-306904-8iteddug	211	30	bilayers	bilayer	NNS
cord-306904-8iteddug	211	31	.	.	.
cord-306904-8iteddug	212	1	73	73	CD
cord-306904-8iteddug	213	1	The	the	DT
cord-306904-8iteddug	213	2	authors	author	NNS
cord-306904-8iteddug	213	3	revealed	reveal	VBD
cord-306904-8iteddug	213	4	that	that	IN
cord-306904-8iteddug	213	5	the	the	DT
cord-306904-8iteddug	213	6	association	association	NN
cord-306904-8iteddug	213	7	of	of	IN
cord-306904-8iteddug	213	8	the	the	DT
cord-306904-8iteddug	213	9	PTEN	PTEN	NNP
cord-306904-8iteddug	213	10	with	with	IN
cord-306904-8iteddug	213	11	such	such	JJ
cord-306904-8iteddug	213	12	bilayers	bilayer	NNS
cord-306904-8iteddug	213	13	involves	involve	VBZ
cord-306904-8iteddug	213	14	the	the	DT
cord-306904-8iteddug	213	15	formation	formation	NN
cord-306904-8iteddug	213	16	of	of	IN
cord-306904-8iteddug	213	17	an	an	DT
cord-306904-8iteddug	213	18	initial	initial	JJ
cord-306904-8iteddug	213	19	electrostatics	electrostatic	NNS
cord-306904-8iteddug	213	20	-	-	HYPH
cord-306904-8iteddug	213	21	driven	drive	VBN
cord-306904-8iteddug	213	22	encounter	encounter	NN
cord-306904-8iteddug	213	23	complex	complex	NN
cord-306904-8iteddug	213	24	between	between	IN
cord-306904-8iteddug	213	25	the	the	DT
cord-306904-8iteddug	213	26	protein	protein	NN
cord-306904-8iteddug	213	27	and	and	CC
cord-306904-8iteddug	213	28	bilayer	bilayer	NN
cord-306904-8iteddug	213	29	followed	follow	VBN
cord-306904-8iteddug	213	30	by	by	IN
cord-306904-8iteddug	213	31	reorientation	reorientation	NN
cord-306904-8iteddug	213	32	of	of	IN
cord-306904-8iteddug	213	33	the	the	DT
cord-306904-8iteddug	213	34	protein	protein	NN
cord-306904-8iteddug	213	35	to	to	TO
cord-306904-8iteddug	213	36	optimize	optimize	VB
cord-306904-8iteddug	213	37	its	-PRON-	PRP$
cord-306904-8iteddug	213	38	interactions	interaction	NNS
cord-306904-8iteddug	213	39	with	with	IN
cord-306904-8iteddug	213	40	PIP	PIP	NNP
cord-306904-8iteddug	213	41	molecules	molecule	NNS
cord-306904-8iteddug	213	42	in	in	IN
cord-306904-8iteddug	213	43	the	the	DT
cord-306904-8iteddug	213	44	membrane	membrane	NN
cord-306904-8iteddug	213	45	.	.	.
cord-306904-8iteddug	214	1	73	73	CD
cord-306904-8iteddug	214	2	PTEN	PTEN	NNP
cord-306904-8iteddug	214	3	is	be	VBZ
cord-306904-8iteddug	214	4	a	a	DT
cord-306904-8iteddug	214	5	cytosolic	cytosolic	JJ
cord-306904-8iteddug	214	6	enzyme	enzyme	NN
cord-306904-8iteddug	214	7	that	that	WDT
cord-306904-8iteddug	214	8	can	can	MD
cord-306904-8iteddug	214	9	interact	interact	VB
cord-306904-8iteddug	214	10	with	with	IN
cord-306904-8iteddug	214	11	the	the	DT
cord-306904-8iteddug	214	12	inner	inner	JJ
cord-306904-8iteddug	214	13	leaflet	leaflet	NN
cord-306904-8iteddug	214	14	of	of	IN
cord-306904-8iteddug	214	15	the	the	DT
cord-306904-8iteddug	214	16	plasma	plasma	NN
cord-306904-8iteddug	214	17	membrane	membrane	NN
cord-306904-8iteddug	214	18	and	and	CC
cord-306904-8iteddug	214	19	,	,	,
cord-306904-8iteddug	214	20	being	be	VBG
cord-306904-8iteddug	214	21	bound	bind	VBN
cord-306904-8iteddug	214	22	to	to	IN
cord-306904-8iteddug	214	23	membrane	membrane	NN
cord-306904-8iteddug	214	24	,	,	,
cord-306904-8iteddug	214	25	catalyzes	catalyze	VBZ
cord-306904-8iteddug	214	26	dephosphorylation	dephosphorylation	NN
cord-306904-8iteddug	214	27	of	of	IN
cord-306904-8iteddug	214	28	PI(3,4,5)P	PI(3,4,5)P	NNP
cord-306904-8iteddug	214	29	3	3	CD
cord-306904-8iteddug	214	30	to	to	IN
cord-306904-8iteddug	214	31	PtdIns(4,5)P	PtdIns(4,5)P	NNP
cord-306904-8iteddug	214	32	2	2	CD
cord-306904-8iteddug	214	33	.	.	.
cord-306904-8iteddug	215	1	74	74	CD
cord-306904-8iteddug	215	2	PTEN	PTEN	NNP
cord-306904-8iteddug	215	3	has	have	VBZ
cord-306904-8iteddug	215	4	4	4	CD
cord-306904-8iteddug	215	5	domains	domain	NNS
cord-306904-8iteddug	215	6	,	,	,
cord-306904-8iteddug	215	7	an	an	DT
cord-306904-8iteddug	215	8	N	n	CD
cord-306904-8iteddug	215	9	-	-	HYPH
cord-306904-8iteddug	215	10	terminal	terminal	NN
cord-306904-8iteddug	215	11	PIP	PIP	NNP
cord-306904-8iteddug	215	12	2	2	CD
cord-306904-8iteddug	215	13	-binding	-binding	NN
cord-306904-8iteddug	215	14	module	module	NN
cord-306904-8iteddug	215	15	,	,	,
cord-306904-8iteddug	215	16	a	a	DT
cord-306904-8iteddug	215	17	phosphatase	phosphatase	NN
cord-306904-8iteddug	215	18	domain	domain	NN
cord-306904-8iteddug	215	19	(	(	-LRB-
cord-306904-8iteddug	215	20	PD	PD	NNP
cord-306904-8iteddug	215	21	)	)	-RRB-
cord-306904-8iteddug	215	22	,	,	,
cord-306904-8iteddug	215	23	a	a	DT
cord-306904-8iteddug	215	24	C2	C2	NNP
cord-306904-8iteddug	215	25	domain	domain	NN
cord-306904-8iteddug	215	26	,	,	,
cord-306904-8iteddug	215	27	and	and	CC
cord-306904-8iteddug	215	28	a	a	DT
cord-306904-8iteddug	215	29	C	c	NN
cord-306904-8iteddug	215	30	-	-	HYPH
cord-306904-8iteddug	215	31	terminal	terminal	NN
cord-306904-8iteddug	215	32	tail	tail	NN
cord-306904-8iteddug	215	33	.	.	.
cord-306904-8iteddug	216	1	Several	several	JJ
cord-306904-8iteddug	216	2	recent	recent	JJ
cord-306904-8iteddug	216	3	studies	study	NNS
cord-306904-8iteddug	216	4	indicated	indicate	VBD
cord-306904-8iteddug	216	5	that	that	IN
cord-306904-8iteddug	216	6	both	both	DT
cord-306904-8iteddug	216	7	Nand	Nand	NNP
cord-306904-8iteddug	216	8	C	C	NNP
cord-306904-8iteddug	216	9	-	-	HYPH
cord-306904-8iteddug	216	10	tails	tail	NNS
cord-306904-8iteddug	216	11	of	of	IN
cord-306904-8iteddug	216	12	this	this	DT
cord-306904-8iteddug	216	13	protein	protein	NN
cord-306904-8iteddug	216	14	are	be	VBP
cord-306904-8iteddug	216	15	intrinsically	intrinsically	RB
cord-306904-8iteddug	216	16	disordered	disordered	JJ
cord-306904-8iteddug	216	17	.	.	.
cord-306904-8iteddug	217	1	[	[	-LRB-
cord-306904-8iteddug	217	2	75	75	CD
cord-306904-8iteddug	217	3	]	]	-RRB-
cord-306904-8iteddug	217	4	[	[	-LRB-
cord-306904-8iteddug	217	5	76	76	CD
cord-306904-8iteddug	217	6	]	]	-RRB-
cord-306904-8iteddug	217	7	[	[	-LRB-
cord-306904-8iteddug	217	8	77	77	CD
cord-306904-8iteddug	217	9	]	]	-RRB-
cord-306904-8iteddug	218	1	Furthermore	furthermore	RB
cord-306904-8iteddug	218	2	,	,	,
cord-306904-8iteddug	218	3	it	-PRON-	PRP
cord-306904-8iteddug	218	4	has	have	VBZ
cord-306904-8iteddug	218	5	been	be	VBN
cord-306904-8iteddug	218	6	emphasized	emphasize	VBN
cord-306904-8iteddug	218	7	that	that	IN
cord-306904-8iteddug	218	8	post	post	JJ
cord-306904-8iteddug	218	9	-	-	JJ
cord-306904-8iteddug	218	10	translational	translational	JJ
cord-306904-8iteddug	218	11	modifications	modification	NNS
cord-306904-8iteddug	218	12	,	,	,
cord-306904-8iteddug	218	13	conserved	conserve	VBN
cord-306904-8iteddug	218	14	eukaryotic	eukaryotic	JJ
cord-306904-8iteddug	218	15	linear	linear	JJ
cord-306904-8iteddug	218	16	motifs	motif	NNS
cord-306904-8iteddug	218	17	,	,	,
cord-306904-8iteddug	218	18	and	and	CC
cord-306904-8iteddug	218	19	molecular	molecular	JJ
cord-306904-8iteddug	218	20	recognition	recognition	NN
cord-306904-8iteddug	218	21	features	feature	NNS
cord-306904-8iteddug	218	22	are	be	VBP
cord-306904-8iteddug	218	23	present	present	JJ
cord-306904-8iteddug	218	24	in	in	IN
cord-306904-8iteddug	218	25	the	the	DT
cord-306904-8iteddug	218	26	disordered	disordered	JJ
cord-306904-8iteddug	218	27	C	c	NN
cord-306904-8iteddug	218	28	-	-	HYPH
cord-306904-8iteddug	218	29	tail	tail	NN
cord-306904-8iteddug	218	30	of	of	IN
cord-306904-8iteddug	218	31	PTEN	PTEN	NNP
cord-306904-8iteddug	218	32	,	,	,
cord-306904-8iteddug	218	33	enhancing	enhance	VBG
cord-306904-8iteddug	218	34	protein	protein	NN
cord-306904-8iteddug	218	35	-	-	HYPH
cord-306904-8iteddug	218	36	protein	protein	NN
cord-306904-8iteddug	218	37	interactions	interaction	NNS
cord-306904-8iteddug	218	38	of	of	IN
cord-306904-8iteddug	218	39	this	this	DT
cord-306904-8iteddug	218	40	protein	protein	NN
cord-306904-8iteddug	218	41	needed	need	VBD
cord-306904-8iteddug	218	42	for	for	IN
cord-306904-8iteddug	218	43	the	the	DT
cord-306904-8iteddug	218	44	various	various	JJ
cord-306904-8iteddug	218	45	cellular	cellular	JJ
cord-306904-8iteddug	218	46	functions	function	NNS
cord-306904-8iteddug	218	47	of	of	IN
cord-306904-8iteddug	218	48	PTEN	PTEN	NNP
cord-306904-8iteddug	218	49	.	.	.
cord-306904-8iteddug	219	1	75	75	CD
cord-306904-8iteddug	219	2	Domain	domain	NN
cord-306904-8iteddug	219	3	swapped	swap	VBD
cord-306904-8iteddug	219	4	Pukovnik	Pukovnik	NNP
cord-306904-8iteddug	219	5	Xis	Xis	NNP
cord-306904-8iteddug	219	6	Singh	Singh	NNP
cord-306904-8iteddug	219	7	et	et	NNP
cord-306904-8iteddug	219	8	al	al	NNP
cord-306904-8iteddug	219	9	.	.	.
cord-306904-8iteddug	220	1	determined	determine	VBD
cord-306904-8iteddug	220	2	the	the	DT
cord-306904-8iteddug	220	3	structure	structure	NN
cord-306904-8iteddug	220	4	of	of	IN
cord-306904-8iteddug	220	5	Pukovnik	Pukovnik	NNP
cord-306904-8iteddug	220	6	Xis	Xis	NNP
cord-306904-8iteddug	220	7	by	by	IN
cord-306904-8iteddug	220	8	X	x	NN
cord-306904-8iteddug	220	9	-	-	NN
cord-306904-8iteddug	220	10	ray	ray	NN
cord-306904-8iteddug	220	11	crystallography	crystallography	NN
cord-306904-8iteddug	220	12	.	.	.
cord-306904-8iteddug	221	1	78	78	CD
cord-306904-8iteddug	222	1	Xis	Xis	NNP
cord-306904-8iteddug	222	2	is	be	VBZ
cord-306904-8iteddug	222	3	the	the	DT
cord-306904-8iteddug	222	4	recombination	recombination	NN
cord-306904-8iteddug	222	5	directionality	directionality	NN
cord-306904-8iteddug	222	6	factor	factor	NN
cord-306904-8iteddug	222	7	that	that	WDT
cord-306904-8iteddug	222	8	serves	serve	VBZ
cord-306904-8iteddug	222	9	as	as	IN
cord-306904-8iteddug	222	10	a	a	DT
cord-306904-8iteddug	222	11	DNA	dna	NN
cord-306904-8iteddug	222	12	bending	bend	VBG
cord-306904-8iteddug	222	13	machine	machine	NN
cord-306904-8iteddug	222	14	that	that	WDT
cord-306904-8iteddug	222	15	difines	difine	VBZ
cord-306904-8iteddug	222	16	the	the	DT
cord-306904-8iteddug	222	17	outcome	outcome	NN
cord-306904-8iteddug	222	18	of	of	IN
cord-306904-8iteddug	222	19	integrase	integrase	NN
cord-306904-8iteddug	222	20	-	-	HYPH
cord-306904-8iteddug	222	21	mediated	mediate	VBN
cord-306904-8iteddug	222	22	site	site	NN
cord-306904-8iteddug	222	23	-	-	HYPH
cord-306904-8iteddug	222	24	specific	specific	JJ
cord-306904-8iteddug	222	25	recombination	recombination	NN
cord-306904-8iteddug	222	26	by	by	IN
cord-306904-8iteddug	222	27	redesign	redesign	NN
cord-306904-8iteddug	222	28	of	of	IN
cord-306904-8iteddug	222	29	higher	high	JJR
cord-306904-8iteddug	222	30	-	-	HYPH
cord-306904-8iteddug	222	31	order	order	NN
cord-306904-8iteddug	222	32	protein	protein	NN
cord-306904-8iteddug	222	33	-	-	HYPH
cord-306904-8iteddug	222	34	DNA	dna	NN
cord-306904-8iteddug	222	35	architectures	architecture	NNS
cord-306904-8iteddug	222	36	.	.	.
cord-306904-8iteddug	223	1	79	79	CD
cord-306904-8iteddug	223	2	Mycobacterium	Mycobacterium	NNP
cord-306904-8iteddug	223	3	phage	phage	NN
cord-306904-8iteddug	223	4	Pukovnik	Pukovnik	NNP
cord-306904-8iteddug	223	5	(	(	-LRB-
cord-306904-8iteddug	223	6	which	which	WDT
cord-306904-8iteddug	223	7	is	be	VBZ
cord-306904-8iteddug	223	8	a	a	DT
cord-306904-8iteddug	223	9	relative	relative	NN
cord-306904-8iteddug	223	10	of	of	IN
cord-306904-8iteddug	223	11	phage	phage	NN
cord-306904-8iteddug	223	12	L5	L5	NNP
cord-306904-8iteddug	223	13	)	)	-RRB-
cord-306904-8iteddug	223	14	contains	contain	VBZ
cord-306904-8iteddug	223	15	a	a	DT
cord-306904-8iteddug	223	16	small	small	JJ
cord-306904-8iteddug	223	17	Xis	Xis	NNP
cord-306904-8iteddug	223	18	protein	protein	NN
cord-306904-8iteddug	223	19	(	(	-LRB-
cord-306904-8iteddug	223	20	56	56	CD
cord-306904-8iteddug	223	21	residues	residue	NNS
cord-306904-8iteddug	223	22	)	)	-RRB-
cord-306904-8iteddug	223	23	that	that	WDT
cord-306904-8iteddug	223	24	binds	bind	VBZ
cord-306904-8iteddug	223	25	cooperatively	cooperatively	RB
cord-306904-8iteddug	223	26	to	to	IN
cord-306904-8iteddug	223	27	attR	attR	NNP
cord-306904-8iteddug	223	28	DNA	DNA	NNP
cord-306904-8iteddug	223	29	at	at	IN
cord-306904-8iteddug	223	30	specific	specific	JJ
cord-306904-8iteddug	223	31	X1-X4	x1-x4	RB
cord-306904-8iteddug	223	32	binding	binding	JJ
cord-306904-8iteddug	223	33	sequences	sequence	NNS
cord-306904-8iteddug	223	34	.	.	.
cord-306904-8iteddug	224	1	Similar	similar	JJ
cord-306904-8iteddug	224	2	to	to	IN
cord-306904-8iteddug	224	3	L5	L5	NNP
cord-306904-8iteddug	224	4	,	,	,
cord-306904-8iteddug	224	5	Pukovnik	Pukovnik	NNP
cord-306904-8iteddug	224	6	Xis	Xis	NNP
cord-306904-8iteddug	224	7	stimulates	stimulate	VBZ
cord-306904-8iteddug	224	8	integrase	integrase	NN
cord-306904-8iteddug	224	9	-	-	HYPH
cord-306904-8iteddug	224	10	mediated	mediate	VBN
cord-306904-8iteddug	224	11	excision	excision	NN
cord-306904-8iteddug	224	12	and	and	CC
cord-306904-8iteddug	224	13	inhibits	inhibit	VBZ
cord-306904-8iteddug	224	14	integration	integration	NN
cord-306904-8iteddug	224	15	.	.	.
cord-306904-8iteddug	225	1	80	80	CD
cord-306904-8iteddug	226	1	,	,	,
cord-306904-8iteddug	226	2	81	81	CD
cord-306904-8iteddug	227	1	The	the	DT
cord-306904-8iteddug	227	2	presence	presence	NN
cord-306904-8iteddug	227	3	of	of	IN
cord-306904-8iteddug	227	4	both	both	CC
cord-306904-8iteddug	227	5	Xis	Xis	NNP
cord-306904-8iteddug	227	6	and	and	CC
cord-306904-8iteddug	227	7	intergrase	intergrase	NNP
cord-306904-8iteddug	227	8	is	be	VBZ
cord-306904-8iteddug	227	9	needed	need	VBN
cord-306904-8iteddug	227	10	for	for	IN
cord-306904-8iteddug	227	11	the	the	DT
cord-306904-8iteddug	227	12	formation	formation	NN
cord-306904-8iteddug	227	13	of	of	IN
cord-306904-8iteddug	227	14	an	an	DT
cord-306904-8iteddug	227	15	attR	attR	NNP
cord-306904-8iteddug	227	16	intasome	intasome	VBN
cord-306904-8iteddug	227	17	.	.	.
cord-306904-8iteddug	228	1	78	78	CD
cord-306904-8iteddug	229	1	The	the	DT
cord-306904-8iteddug	229	2	cooperative	cooperative	JJ
cord-306904-8iteddug	229	3	binding	binding	NN
cord-306904-8iteddug	229	4	of	of	IN
cord-306904-8iteddug	229	5	several	several	JJ
cord-306904-8iteddug	229	6	Xis	Xis	NNP
cord-306904-8iteddug	229	7	proteins	protein	NNS
cord-306904-8iteddug	229	8	to	to	IN
cord-306904-8iteddug	229	9	DNA	DNA	NNP
cord-306904-8iteddug	229	10	is	be	VBZ
cord-306904-8iteddug	229	11	driven	drive	VBN
cord-306904-8iteddug	229	12	by	by	IN
cord-306904-8iteddug	229	13	a	a	DT
cord-306904-8iteddug	229	14	wingedhelix	wingedhelix	VBN
cord-306904-8iteddug	229	15	motif	motif	NN
cord-306904-8iteddug	229	16	and	and	CC
cord-306904-8iteddug	229	17	relies	rely	VBZ
cord-306904-8iteddug	229	18	on	on	IN
cord-306904-8iteddug	229	19	the	the	DT
cord-306904-8iteddug	229	20	use	use	NN
cord-306904-8iteddug	229	21	of	of	IN
cord-306904-8iteddug	229	22	contacts	contact	NNS
cord-306904-8iteddug	229	23	between	between	IN
cord-306904-8iteddug	229	24	a	a	DT
cord-306904-8iteddug	229	25	central	central	JJ
cord-306904-8iteddug	229	26	loop	loop	NN
cord-306904-8iteddug	229	27	and	and	CC
cord-306904-8iteddug	229	28	the	the	DT
cord-306904-8iteddug	229	29	wing	wing	NN
cord-306904-8iteddug	229	30	motif	motif	NN
cord-306904-8iteddug	229	31	to	to	TO
cord-306904-8iteddug	229	32	mediate	mediate	VB
cord-306904-8iteddug	229	33	interactions	interaction	NNS
cord-306904-8iteddug	229	34	between	between	IN
cord-306904-8iteddug	229	35	Xis	Xis	NNP
cord-306904-8iteddug	229	36	proteins	protein	NNS
cord-306904-8iteddug	229	37	when	when	WRB
cord-306904-8iteddug	229	38	bound	bind	VBN
cord-306904-8iteddug	229	39	to	to	IN
cord-306904-8iteddug	229	40	DNA	dna	NN
cord-306904-8iteddug	229	41	leading	lead	VBG
cord-306904-8iteddug	229	42	to	to	IN
cord-306904-8iteddug	229	43	the	the	DT
cord-306904-8iteddug	229	44	formation	formation	NN
cord-306904-8iteddug	229	45	of	of	IN
cord-306904-8iteddug	229	46	a	a	DT
cord-306904-8iteddug	229	47	micronucleoprotein	micronucleoprotein	NNP
cord-306904-8iteddug	229	48	filament	filament	NN
cord-306904-8iteddug	229	49	with	with	IN
cord-306904-8iteddug	229	50	a	a	DT
cord-306904-8iteddug	229	51	modest	modest	JJ
cord-306904-8iteddug	229	52	bend	bend	NN
cord-306904-8iteddug	229	53	.	.	.
cord-306904-8iteddug	230	1	78	78	CD
cord-306904-8iteddug	230	2	,	,	,
cord-306904-8iteddug	230	3	82	82	CD
cord-306904-8iteddug	231	1	,	,	,
cord-306904-8iteddug	231	2	83	83	CD
cord-306904-8iteddug	231	3	Singh	Singh	NNP
cord-306904-8iteddug	231	4	et	et	NNP
cord-306904-8iteddug	231	5	al	al	NNP
cord-306904-8iteddug	231	6	.	.	.
cord-306904-8iteddug	232	1	showed	show	VBD
cord-306904-8iteddug	232	2	that	that	IN
cord-306904-8iteddug	232	3	in	in	IN
cord-306904-8iteddug	232	4	the	the	DT
cord-306904-8iteddug	232	5	DNAbound	dnabound	NN
cord-306904-8iteddug	232	6	form	form	NN
cord-306904-8iteddug	232	7	,	,	,
cord-306904-8iteddug	232	8	5	5	CD
cord-306904-8iteddug	232	9	individual	individual	JJ
cord-306904-8iteddug	232	10	Pukovnik	Pukovnik	NNP
cord-306904-8iteddug	232	11	Xis	Xis	NNP
cord-306904-8iteddug	232	12	subunits	subunit	NNS
cord-306904-8iteddug	232	13	stack	stack	VBP
cord-306904-8iteddug	232	14	onto	onto	IN
cord-306904-8iteddug	232	15	each	each	DT
cord-306904-8iteddug	232	16	other	other	JJ
cord-306904-8iteddug	232	17	through	through	IN
cord-306904-8iteddug	232	18	an	an	DT
cord-306904-8iteddug	232	19	extensive	extensive	JJ
cord-306904-8iteddug	232	20	array	array	NN
cord-306904-8iteddug	232	21	of	of	IN
cord-306904-8iteddug	232	22	protein	protein	NN
cord-306904-8iteddug	232	23	-	-	HYPH
cord-306904-8iteddug	232	24	protein	protein	NN
cord-306904-8iteddug	232	25	interactions	interaction	NNS
cord-306904-8iteddug	232	26	forming	form	VBG
cord-306904-8iteddug	232	27	a	a	DT
cord-306904-8iteddug	232	28	filament	filament	NN
cord-306904-8iteddug	232	29	with	with	IN
cord-306904-8iteddug	232	30	left	left	JJ
cord-306904-8iteddug	232	31	-	-	HYPH
cord-306904-8iteddug	232	32	handed	handed	JJ
cord-306904-8iteddug	232	33	superhelical	superhelical	JJ
cord-306904-8iteddug	232	34	twist	twist	NN
cord-306904-8iteddug	232	35	.	.	.
cord-306904-8iteddug	233	1	78	78	CD
cord-306904-8iteddug	233	2	Stacking	stacking	NN
cord-306904-8iteddug	233	3	of	of	IN
cord-306904-8iteddug	233	4	Xis	Xis	NNP
cord-306904-8iteddug	233	5	subunits	subunit	NNS
cord-306904-8iteddug	233	6	within	within	IN
cord-306904-8iteddug	233	7	the	the	DT
cord-306904-8iteddug	233	8	filament	filament	NN
cord-306904-8iteddug	233	9	is	be	VBZ
cord-306904-8iteddug	233	10	rather	rather	RB
cord-306904-8iteddug	233	11	regular	regular	JJ
cord-306904-8iteddug	233	12	,	,	,
cord-306904-8iteddug	233	13	and	and	CC
cord-306904-8iteddug	233	14	each	each	DT
cord-306904-8iteddug	233	15	monomer	monomer	NN
cord-306904-8iteddug	233	16	exhibits	exhibit	VBZ
cord-306904-8iteddug	233	17	a	a	DT
cord-306904-8iteddug	233	18	twist	twist	NN
cord-306904-8iteddug	233	19	of	of	IN
cord-306904-8iteddug	233	20	40	40	CD
cord-306904-8iteddug	233	21	and	and	CC
cord-306904-8iteddug	233	22	an	an	DT
cord-306904-8iteddug	233	23	»	»	CD
cord-306904-8iteddug	233	24	60	60	CD
cord-306904-8iteddug	233	25	bending	bend	VBG
cord-306904-8iteddug	233	26	angle	angle	NN
cord-306904-8iteddug	233	27	.	.	.
cord-306904-8iteddug	234	1	Within	within	IN
cord-306904-8iteddug	234	2	the	the	DT
cord-306904-8iteddug	234	3	asymmetric	asymmetric	JJ
cord-306904-8iteddug	234	4	unit	unit	NN
cord-306904-8iteddug	234	5	,	,	,
cord-306904-8iteddug	234	6	the	the	DT
cord-306904-8iteddug	234	7	filament	filament	NN
cord-306904-8iteddug	234	8	region	region	NN
cord-306904-8iteddug	234	9	contains	contain	VBZ
cord-306904-8iteddug	234	10	4	4	CD
cord-306904-8iteddug	234	11	Xis	Xis	NNP
cord-306904-8iteddug	234	12	protomers	protomer	NNS
cord-306904-8iteddug	234	13	whereas	whereas	IN
cord-306904-8iteddug	234	14	the	the	DT
cord-306904-8iteddug	234	15	fifth	fifth	JJ
cord-306904-8iteddug	234	16	protomer	protomer	NN
cord-306904-8iteddug	234	17	is	be	VBZ
cord-306904-8iteddug	234	18	positioned	position	VBN
cord-306904-8iteddug	234	19	adjacent	adjacent	JJ
cord-306904-8iteddug	234	20	to	to	IN
cord-306904-8iteddug	234	21	the	the	DT
cord-306904-8iteddug	234	22	filament	filament	NN
cord-306904-8iteddug	234	23	.	.	.
cord-306904-8iteddug	235	1	This	this	DT
cord-306904-8iteddug	235	2	"	"	``
cord-306904-8iteddug	235	3	outside	outside	JJ
cord-306904-8iteddug	235	4	"	"	''
cord-306904-8iteddug	235	5	protomer	protomer	VBD
cord-306904-8iteddug	235	6	forms	form	NNS
cord-306904-8iteddug	235	7	the	the	DT
cord-306904-8iteddug	235	8	domain	domain	NN
cord-306904-8iteddug	235	9	-	-	HYPH
cord-306904-8iteddug	235	10	swapped	swap	VBN
cord-306904-8iteddug	235	11	complex	complex	NN
cord-306904-8iteddug	235	12	with	with	IN
cord-306904-8iteddug	235	13	the	the	DT
cord-306904-8iteddug	235	14	Xis	Xis	NNP
cord-306904-8iteddug	235	15	protomer	protomer	NNP
cord-306904-8iteddug	235	16	3	3	CD
cord-306904-8iteddug	235	17	.	.	.
cord-306904-8iteddug	236	1	This	this	DT
cord-306904-8iteddug	236	2	domain	domain	NN
cord-306904-8iteddug	236	3	-	-	HYPH
cord-306904-8iteddug	236	4	swapped	swap	VBN
cord-306904-8iteddug	236	5	Xis	Xis	NNP
cord-306904-8iteddug	236	6	59	59	CD
cord-306904-8iteddug	236	7	STRING	string	NN
cord-306904-8iteddug	236	8	produces	produce	VBZ
cord-306904-8iteddug	236	9	the	the	DT
cord-306904-8iteddug	236	10	network	network	NN
cord-306904-8iteddug	236	11	of	of	IN
cord-306904-8iteddug	236	12	predicted	predict	VBN
cord-306904-8iteddug	236	13	associations	association	NNS
cord-306904-8iteddug	236	14	for	for	IN
cord-306904-8iteddug	236	15	a	a	DT
cord-306904-8iteddug	236	16	particular	particular	JJ
cord-306904-8iteddug	236	17	group	group	NN
cord-306904-8iteddug	236	18	of	of	IN
cord-306904-8iteddug	236	19	proteins	protein	NNS
cord-306904-8iteddug	236	20	.	.	.
cord-306904-8iteddug	237	1	The	the	DT
cord-306904-8iteddug	237	2	network	network	NN
cord-306904-8iteddug	237	3	nodes	node	NNS
cord-306904-8iteddug	237	4	are	be	VBP
cord-306904-8iteddug	237	5	proteins	protein	NNS
cord-306904-8iteddug	237	6	.	.	.
cord-306904-8iteddug	238	1	The	the	DT
cord-306904-8iteddug	238	2	edges	edge	NNS
cord-306904-8iteddug	238	3	represent	represent	VBP
cord-306904-8iteddug	238	4	the	the	DT
cord-306904-8iteddug	238	5	predicted	predict	VBN
cord-306904-8iteddug	238	6	functional	functional	JJ
cord-306904-8iteddug	238	7	associations	association	NNS
cord-306904-8iteddug	238	8	.	.	.
cord-306904-8iteddug	239	1	An	an	DT
cord-306904-8iteddug	239	2	edge	edge	NN
cord-306904-8iteddug	239	3	may	may	MD
cord-306904-8iteddug	239	4	be	be	VB
cord-306904-8iteddug	239	5	drawn	draw	VBN
cord-306904-8iteddug	239	6	with	with	IN
cord-306904-8iteddug	239	7	up	up	IN
cord-306904-8iteddug	239	8	to	to	TO
cord-306904-8iteddug	239	9	7	7	CD
cord-306904-8iteddug	239	10	differently	differently	RB
cord-306904-8iteddug	239	11	colored	color	VBN
cord-306904-8iteddug	239	12	lines	line	NNS
cord-306904-8iteddug	240	1	-these	-these	JJ
cord-306904-8iteddug	240	2	lines	line	NNS
cord-306904-8iteddug	240	3	represent	represent	VBP
cord-306904-8iteddug	240	4	the	the	DT
cord-306904-8iteddug	240	5	existence	existence	NN
cord-306904-8iteddug	240	6	of	of	IN
cord-306904-8iteddug	240	7	the	the	DT
cord-306904-8iteddug	240	8	7	7	CD
cord-306904-8iteddug	240	9	types	type	NNS
cord-306904-8iteddug	240	10	of	of	IN
cord-306904-8iteddug	240	11	evidence	evidence	NN
cord-306904-8iteddug	240	12	used	use	VBN
cord-306904-8iteddug	240	13	in	in	IN
cord-306904-8iteddug	240	14	predicting	predict	VBG
cord-306904-8iteddug	240	15	the	the	DT
cord-306904-8iteddug	240	16	associations	association	NNS
cord-306904-8iteddug	240	17	.	.	.
cord-306904-8iteddug	241	1	A	a	DT
cord-306904-8iteddug	241	2	red	red	JJ
cord-306904-8iteddug	241	3	line	line	NN
cord-306904-8iteddug	241	4	indicates	indicate	VBZ
cord-306904-8iteddug	241	5	the	the	DT
cord-306904-8iteddug	241	6	presence	presence	NN
cord-306904-8iteddug	241	7	of	of	IN
cord-306904-8iteddug	241	8	fusion	fusion	NN
cord-306904-8iteddug	241	9	evidence	evidence	NN
cord-306904-8iteddug	241	10	;	;	:
cord-306904-8iteddug	241	11	a	a	DT
cord-306904-8iteddug	241	12	green	green	JJ
cord-306904-8iteddug	241	13	line	line	NN
cord-306904-8iteddug	241	14	-neighborhood	-neighborhood	HYPH
cord-306904-8iteddug	241	15	evidence	evidence	NN
cord-306904-8iteddug	241	16	;	;	:
cord-306904-8iteddug	241	17	a	a	DT
cord-306904-8iteddug	241	18	blue	blue	JJ
cord-306904-8iteddug	241	19	lineco	lineco	NN
cord-306904-8iteddug	241	20	-	-	HYPH
cord-306904-8iteddug	241	21	occurrence	occurrence	NN
cord-306904-8iteddug	241	22	evidence	evidence	NN
cord-306904-8iteddug	241	23	;	;	:
cord-306904-8iteddug	241	24	a	a	DT
cord-306904-8iteddug	241	25	purple	purple	JJ
cord-306904-8iteddug	241	26	line	line	NN
cord-306904-8iteddug	241	27	-experimental	-experimental	JJ
cord-306904-8iteddug	241	28	evidence	evidence	NN
cord-306904-8iteddug	241	29	;	;	:
cord-306904-8iteddug	241	30	a	a	DT
cord-306904-8iteddug	241	31	yellow	yellow	JJ
cord-306904-8iteddug	241	32	linetext	linetext	JJ
cord-306904-8iteddug	241	33	mining	mining	NN
cord-306904-8iteddug	241	34	evidence	evidence	NN
cord-306904-8iteddug	241	35	;	;	:
cord-306904-8iteddug	241	36	a	a	DT
cord-306904-8iteddug	241	37	light	light	JJ
cord-306904-8iteddug	241	38	blue	blue	JJ
cord-306904-8iteddug	241	39	line	line	NN
cord-306904-8iteddug	241	40	-database	-database	HYPH
cord-306904-8iteddug	241	41	evidence	evidence	NN
cord-306904-8iteddug	241	42	;	;	:
cord-306904-8iteddug	241	43	a	a	DT
cord-306904-8iteddug	241	44	black	black	JJ
cord-306904-8iteddug	241	45	lineco	lineco	NN
cord-306904-8iteddug	241	46	-	-	HYPH
cord-306904-8iteddug	241	47	expression	expression	NN
cord-306904-8iteddug	241	48	evidence	evidence	NN
cord-306904-8iteddug	241	49	.	.	.
cord-306904-8iteddug	242	1	59	59	CD
cord-306904-8iteddug	243	1	(	(	-LRB-
cord-306904-8iteddug	243	2	B	b	NN
cord-306904-8iteddug	243	3	)	)	-RRB-
cord-306904-8iteddug	244	1	Intrinsic	intrinsic	JJ
cord-306904-8iteddug	244	2	disorder	disorder	NN
cord-306904-8iteddug	244	3	propensity	propensity	NN
cord-306904-8iteddug	244	4	of	of	IN
cord-306904-8iteddug	244	5	the	the	DT
cord-306904-8iteddug	244	6	human	human	JJ
cord-306904-8iteddug	244	7	viperin	viperin	NN
cord-306904-8iteddug	244	8	.	.	.
cord-306904-8iteddug	245	1	Disorder	disorder	NN
cord-306904-8iteddug	245	2	propensity	propensity	NN
cord-306904-8iteddug	245	3	was	be	VBD
cord-306904-8iteddug	245	4	evaluated	evaluate	VBN
cord-306904-8iteddug	245	5	by	by	IN
cord-306904-8iteddug	245	6	a	a	DT
cord-306904-8iteddug	245	7	set	set	NN
cord-306904-8iteddug	245	8	of	of	IN
cord-306904-8iteddug	245	9	predictors	predictor	NNS
cord-306904-8iteddug	245	10	from	from	IN
cord-306904-8iteddug	245	11	the	the	DT
cord-306904-8iteddug	245	12	PONDR	PONDR	NNP
cord-306904-8iteddug	245	13	family	family	NN
cord-306904-8iteddug	245	14	,	,	,
cord-306904-8iteddug	245	15	PONDR	PONDR	NNP
cord-306904-8iteddug	245	16	Ò	Ò	NNP
cord-306904-8iteddug	245	17	FIT	FIT	NNP
cord-306904-8iteddug	245	18	,	,	,
cord-306904-8iteddug	245	19	VSL2B	vsl2b	NN
cord-306904-8iteddug	245	20	,	,	,
cord-306904-8iteddug	245	21	VL3	vl3	NN
cord-306904-8iteddug	245	22	,	,	,
cord-306904-8iteddug	245	23	and	and	CC
cord-306904-8iteddug	245	24	VLXT	VLXT	NNP
cord-306904-8iteddug	245	25	.	.	.
cord-306904-8iteddug	246	1	Scores	score	NNS
cord-306904-8iteddug	246	2	above	above	IN
cord-306904-8iteddug	246	3	0.5	0.5	CD
cord-306904-8iteddug	246	4	correspond	correspond	VBP
cord-306904-8iteddug	246	5	to	to	IN
cord-306904-8iteddug	246	6	disordered	disordered	JJ
cord-306904-8iteddug	246	7	residues	residue	NNS
cord-306904-8iteddug	246	8	/	/	SYM
cord-306904-8iteddug	246	9	regions	region	NNS
cord-306904-8iteddug	246	10	.	.	.
cord-306904-8iteddug	247	1	pair	pair	NN
cord-306904-8iteddug	247	2	is	be	VBZ
cord-306904-8iteddug	247	3	created	create	VBN
cord-306904-8iteddug	247	4	due	due	IN
cord-306904-8iteddug	247	5	to	to	IN
cord-306904-8iteddug	247	6	a	a	DT
cord-306904-8iteddug	247	7	dramatic	dramatic	JJ
cord-306904-8iteddug	247	8	rearrangement	rearrangement	NN
cord-306904-8iteddug	247	9	within	within	IN
cord-306904-8iteddug	247	10	the	the	DT
cord-306904-8iteddug	247	11	loop	loop	NN
cord-306904-8iteddug	247	12	connecting	connect	VBG
cord-306904-8iteddug	247	13	b1	b1	NN
cord-306904-8iteddug	247	14	and	and	CC
cord-306904-8iteddug	247	15	b2	b2	NN
cord-306904-8iteddug	247	16	(	(	-LRB-
cord-306904-8iteddug	247	17	residues	residue	NNS
cord-306904-8iteddug	247	18	36	36	CD
cord-306904-8iteddug	247	19	-	-	SYM
cord-306904-8iteddug	247	20	39	39	CD
cord-306904-8iteddug	247	21	)	)	-RRB-
cord-306904-8iteddug	247	22	allowing	allow	VBG
cord-306904-8iteddug	247	23	the	the	DT
cord-306904-8iteddug	247	24	C	C	NNP
cord-306904-8iteddug	247	25	-	-	HYPH
cord-306904-8iteddug	247	26	terminal	terminal	NN
cord-306904-8iteddug	247	27	residues	residue	NNS
cord-306904-8iteddug	247	28	40	40	CD
cord-306904-8iteddug	247	29	-	-	SYM
cord-306904-8iteddug	247	30	56	56	CD
cord-306904-8iteddug	247	31	of	of	IN
cord-306904-8iteddug	247	32	one	one	CD
cord-306904-8iteddug	247	33	subunit	subunit	NN
cord-306904-8iteddug	247	34	to	to	TO
cord-306904-8iteddug	247	35	interact	interact	VB
cord-306904-8iteddug	247	36	with	with	IN
cord-306904-8iteddug	247	37	the	the	DT
cord-306904-8iteddug	247	38	N	n	CD
cord-306904-8iteddug	247	39	-	-	HYPH
cord-306904-8iteddug	247	40	terminal	terminal	NN
cord-306904-8iteddug	247	41	35	35	CD
cord-306904-8iteddug	247	42	residues	residue	NNS
cord-306904-8iteddug	247	43	of	of	IN
cord-306904-8iteddug	247	44	a	a	DT
cord-306904-8iteddug	247	45	neighboring	neighbor	VBG
cord-306904-8iteddug	247	46	Xis	Xis	NNP
cord-306904-8iteddug	247	47	monomer	monomer	NN
cord-306904-8iteddug	247	48	.	.	.
cord-306904-8iteddug	248	1	78	78	CD
cord-306904-8iteddug	249	1	It	-PRON-	PRP
cord-306904-8iteddug	249	2	has	have	VBZ
cord-306904-8iteddug	249	3	been	be	VBN
cord-306904-8iteddug	249	4	emphasized	emphasize	VBN
cord-306904-8iteddug	249	5	that	that	IN
cord-306904-8iteddug	249	6	the	the	DT
cord-306904-8iteddug	249	7	most	most	RBS
cord-306904-8iteddug	249	8	important	important	JJ
cord-306904-8iteddug	249	9	protein	protein	NN
cord-306904-8iteddug	249	10	-	-	HYPH
cord-306904-8iteddug	249	11	protein	protein	NN
cord-306904-8iteddug	249	12	interactions	interaction	NNS
cord-306904-8iteddug	249	13	mediating	mediate	VBG
cord-306904-8iteddug	249	14	the	the	DT
cord-306904-8iteddug	249	15	filament	filament	NN
cord-306904-8iteddug	249	16	formation	formation	NN
cord-306904-8iteddug	249	17	are	be	VBP
cord-306904-8iteddug	249	18	formed	form	VBN
cord-306904-8iteddug	249	19	by	by	IN
cord-306904-8iteddug	249	20	residues	residue	NNS
cord-306904-8iteddug	249	21	51	51	CD
cord-306904-8iteddug	249	22	-	-	SYM
cord-306904-8iteddug	249	23	54	54	CD
cord-306904-8iteddug	249	24	of	of	IN
cord-306904-8iteddug	249	25	Pukovnik	Pukovnik	NNP
cord-306904-8iteddug	249	26	Xis	Xis	NNP
cord-306904-8iteddug	249	27	that	that	WDT
cord-306904-8iteddug	249	28	make	make	VBP
cord-306904-8iteddug	249	29	extensive	extensive	JJ
cord-306904-8iteddug	249	30	contacts	contact	NNS
cord-306904-8iteddug	249	31	with	with	IN
cord-306904-8iteddug	249	32	the	the	DT
cord-306904-8iteddug	249	33	wing	wing	NN
cord-306904-8iteddug	249	34	of	of	IN
cord-306904-8iteddug	249	35	the	the	DT
cord-306904-8iteddug	249	36	adjacent	adjacent	JJ
cord-306904-8iteddug	249	37	monomer	monomer	NN
cord-306904-8iteddug	249	38	and	and	CC
cord-306904-8iteddug	249	39	deletion	deletion	NN
cord-306904-8iteddug	249	40	of	of	IN
cord-306904-8iteddug	249	41	which	which	WDT
cord-306904-8iteddug	249	42	greatly	greatly	RB
cord-306904-8iteddug	249	43	diminishes	diminish	VBZ
cord-306904-8iteddug	249	44	DNA	dna	NN
cord-306904-8iteddug	249	45	binding	bind	VBG
cord-306904-8iteddug	249	46	affinity	affinity	NN
cord-306904-8iteddug	249	47	and	and	CC
cord-306904-8iteddug	249	48	abolishes	abolish	VBZ
cord-306904-8iteddug	249	49	excision	excision	NN
cord-306904-8iteddug	249	50	.	.	.
cord-306904-8iteddug	250	1	78	78	CD
cord-306904-8iteddug	251	1	Therefore	therefore	RB
cord-306904-8iteddug	251	2	,	,	,
cord-306904-8iteddug	251	3	although	although	IN
cord-306904-8iteddug	251	4	the	the	DT
cord-306904-8iteddug	251	5	Xis	Xis	NNP
cord-306904-8iteddug	251	6	filament	filament	NN
cord-306904-8iteddug	251	7	is	be	VBZ
cord-306904-8iteddug	251	8	composed	compose	VBN
cord-306904-8iteddug	251	9	of	of	IN
cord-306904-8iteddug	251	10	identical	identical	JJ
cord-306904-8iteddug	251	11	subunits	subunit	NNS
cord-306904-8iteddug	251	12	,	,	,
cord-306904-8iteddug	251	13	the	the	DT
cord-306904-8iteddug	251	14	individual	individual	JJ
cord-306904-8iteddug	251	15	Xis	Xis	NNP
cord-306904-8iteddug	251	16	protomers	protomer	NNS
cord-306904-8iteddug	251	17	are	be	VBP
cord-306904-8iteddug	251	18	involved	involve	VBN
cord-306904-8iteddug	251	19	in	in	IN
cord-306904-8iteddug	251	20	very	very	RB
cord-306904-8iteddug	251	21	different	different	JJ
cord-306904-8iteddug	251	22	interactions	interaction	NNS
cord-306904-8iteddug	251	23	and	and	CC
cord-306904-8iteddug	251	24	form	form	VBP
cord-306904-8iteddug	251	25	very	very	RB
cord-306904-8iteddug	251	26	different	different	JJ
cord-306904-8iteddug	251	27	interfaces	interface	NNS
cord-306904-8iteddug	251	28	.	.	.
cord-306904-8iteddug	252	1	To	to	TO
cord-306904-8iteddug	252	2	further	further	RB
cord-306904-8iteddug	252	3	illustrate	illustrate	VB
cord-306904-8iteddug	252	4	this	this	DT
cord-306904-8iteddug	252	5	point	point	NN
cord-306904-8iteddug	252	6	,	,	,
cord-306904-8iteddug	252	7	Figure	figure	NN
cord-306904-8iteddug	252	8	7A	7a	NN
cord-306904-8iteddug	252	9	represents	represent	VBZ
cord-306904-8iteddug	252	10	a	a	DT
cord-306904-8iteddug	252	11	crystal	crystal	JJ
cord-306904-8iteddug	252	12	structure	structure	NN
cord-306904-8iteddug	252	13	of	of	IN
cord-306904-8iteddug	252	14	the	the	DT
cord-306904-8iteddug	252	15	Pukovnik	Pukovnik	NNP
cord-306904-8iteddug	252	16	Xis	Xis	NNP
cord-306904-8iteddug	252	17	pentamer	pentamer	NNP
cord-306904-8iteddug	252	18	(	(	-LRB-
cord-306904-8iteddug	252	19	PDB	PDB	NNP
cord-306904-8iteddug	252	20	ID	ID	NNP
cord-306904-8iteddug	252	21	:	:	:
cord-306904-8iteddug	252	22	4J2N	4j2n	CD
cord-306904-8iteddug	252	23	)	)	-RRB-
cord-306904-8iteddug	252	24	and	and	CC
cord-306904-8iteddug	252	25	4	4	CD
cord-306904-8iteddug	252	26	pairs	pair	NNS
cord-306904-8iteddug	252	27	of	of	IN
cord-306904-8iteddug	252	28	different	different	JJ
cord-306904-8iteddug	252	29	dimers	dimer	NNS
cord-306904-8iteddug	252	30	found	find	VBN
cord-306904-8iteddug	252	31	within	within	IN
cord-306904-8iteddug	252	32	this	this	DT
cord-306904-8iteddug	252	33	pentameric	pentameric	NN
cord-306904-8iteddug	252	34	filament	filament	NN
cord-306904-8iteddug	252	35	.	.	.
cord-306904-8iteddug	253	1	Figure	figure	NN
cord-306904-8iteddug	253	2	7B	7b	NN
cord-306904-8iteddug	253	3	shows	show	VBZ
cord-306904-8iteddug	253	4	that	that	IN
cord-306904-8iteddug	253	5	Pukovnik	Pukovnik	NNP
cord-306904-8iteddug	253	6	Xis	Xis	NNP
cord-306904-8iteddug	253	7	(	(	-LRB-
cord-306904-8iteddug	253	8	UniProt	UniProt	NNP
cord-306904-8iteddug	253	9	ID	ID	NNP
cord-306904-8iteddug	253	10	:	:	:
cord-306904-8iteddug	253	11	B3VGI6	b3vgi6	NN
cord-306904-8iteddug	253	12	)	)	-RRB-
cord-306904-8iteddug	253	13	is	be	VBZ
cord-306904-8iteddug	253	14	predicted	predict	VBN
cord-306904-8iteddug	253	15	to	to	TO
cord-306904-8iteddug	253	16	contain	contain	VB
cord-306904-8iteddug	253	17	substantial	substantial	JJ
cord-306904-8iteddug	253	18	amount	amount	NN
cord-306904-8iteddug	253	19	of	of	IN
cord-306904-8iteddug	253	20	intrinsic	intrinsic	JJ
cord-306904-8iteddug	253	21	disorder	disorder	NN
cord-306904-8iteddug	253	22	(	(	-LRB-
cord-306904-8iteddug	253	23	note	note	NN
cord-306904-8iteddug	253	24	scale	scale	NN
cord-306904-8iteddug	253	25	of	of	IN
cord-306904-8iteddug	253	26	the	the	DT
cord-306904-8iteddug	253	27	Yaxis	Yaxis	NNP
cord-306904-8iteddug	253	28	)	)	-RRB-
cord-306904-8iteddug	253	29	,	,	,
cord-306904-8iteddug	253	30	including	include	VBG
cord-306904-8iteddug	253	31	disordered	disordered	JJ
cord-306904-8iteddug	253	32	N	N	NNP
cord-306904-8iteddug	253	33	-	-	HYPH
cord-306904-8iteddug	253	34	and	and	CC
cord-306904-8iteddug	253	35	C	c	NN
cord-306904-8iteddug	253	36	-	-	HYPH
cord-306904-8iteddug	253	37	terminal	terminal	NN
cord-306904-8iteddug	253	38	tails	tail	NNS
cord-306904-8iteddug	253	39	.	.	.
cord-306904-8iteddug	254	1	Therefore	therefore	RB
cord-306904-8iteddug	254	2	,	,	,
cord-306904-8iteddug	254	3	it	-PRON-	PRP
cord-306904-8iteddug	254	4	is	be	VBZ
cord-306904-8iteddug	254	5	likely	likely	JJ
cord-306904-8iteddug	254	6	that	that	IN
cord-306904-8iteddug	254	7	the	the	DT
cord-306904-8iteddug	254	8	intrinsically	intrinsically	RB
cord-306904-8iteddug	254	9	disordered	disordered	JJ
cord-306904-8iteddug	254	10	nature	nature	NN
cord-306904-8iteddug	254	11	determines	determine	VBZ
cord-306904-8iteddug	254	12	the	the	DT
cord-306904-8iteddug	254	13	ability	ability	NN
cord-306904-8iteddug	254	14	of	of	IN
cord-306904-8iteddug	254	15	this	this	DT
cord-306904-8iteddug	254	16	small	small	JJ
cord-306904-8iteddug	254	17	protein	protein	NN
cord-306904-8iteddug	254	18	to	to	TO
cord-306904-8iteddug	254	19	be	be	VB
cord-306904-8iteddug	254	20	involved	involve	VBN
cord-306904-8iteddug	254	21	in	in	IN
cord-306904-8iteddug	254	22	a	a	DT
cord-306904-8iteddug	254	23	complex	complex	JJ
cord-306904-8iteddug	254	24	net	net	NN
cord-306904-8iteddug	254	25	of	of	IN
cord-306904-8iteddug	254	26	proteinprotein	proteinprotein	NNP
cord-306904-8iteddug	254	27	and	and	CC
cord-306904-8iteddug	254	28	protein	protein	NN
cord-306904-8iteddug	254	29	-	-	HYPH
cord-306904-8iteddug	254	30	DNA	dna	NN
cord-306904-8iteddug	254	31	interactions	interaction	NNS
cord-306904-8iteddug	254	32	,	,	,
cord-306904-8iteddug	254	33	including	include	VBG
cord-306904-8iteddug	254	34	its	-PRON-	PRP$
cord-306904-8iteddug	254	35	ability	ability	NN
cord-306904-8iteddug	254	36	to	to	TO
cord-306904-8iteddug	254	37	form	form	VB
cord-306904-8iteddug	254	38	a	a	DT
cord-306904-8iteddug	254	39	wide	wide	JJ
cord-306904-8iteddug	254	40	array	array	NN
cord-306904-8iteddug	254	41	of	of	IN
cord-306904-8iteddug	254	42	regular	regular	JJ
cord-306904-8iteddug	254	43	and	and	CC
cord-306904-8iteddug	254	44	domain	domain	NN
cord-306904-8iteddug	254	45	-	-	HYPH
cord-306904-8iteddug	254	46	swapped	swap	VBN
cord-306904-8iteddug	254	47	dimers	dimer	NNS
cord-306904-8iteddug	254	48	.	.	.
cord-306904-8iteddug	255	1	Li	Li	NNP
cord-306904-8iteddug	255	2	et	et	NNP
cord-306904-8iteddug	255	3	al	al	NNP
cord-306904-8iteddug	255	4	.	.	.
cord-306904-8iteddug	256	1	provided	provide	VBD
cord-306904-8iteddug	256	2	a	a	DT
cord-306904-8iteddug	256	3	detailed	detailed	JJ
cord-306904-8iteddug	256	4	characterization	characterization	NN
cord-306904-8iteddug	256	5	of	of	IN
cord-306904-8iteddug	256	6	the	the	DT
cord-306904-8iteddug	256	7	functional	functional	JJ
cord-306904-8iteddug	256	8	mechanisms	mechanism	NNS
cord-306904-8iteddug	256	9	of	of	IN
cord-306904-8iteddug	256	10	interesting	interesting	JJ
cord-306904-8iteddug	256	11	Hsp90	Hsp90	NNP
cord-306904-8iteddug	256	12	co	co	NNS
cord-306904-8iteddug	256	13	-	-	NNS
cord-306904-8iteddug	256	14	chaperones	chaperone	NNS
cord-306904-8iteddug	256	15	,	,	,
cord-306904-8iteddug	256	16	human	human	JJ
cord-306904-8iteddug	256	17	aryl	aryl	NN
cord-306904-8iteddug	256	18	hydrocarbon	hydrocarbon	NN
cord-306904-8iteddug	256	19	receptor	receptor	NN
cord-306904-8iteddug	256	20	(	(	-LRB-
cord-306904-8iteddug	256	21	AHR	AHR	NNP
cord-306904-8iteddug	256	22	)	)	-RRB-
cord-306904-8iteddug	256	23	interacting	interact	VBG
cord-306904-8iteddug	256	24	protein	protein	NN
cord-306904-8iteddug	256	25	(	(	-LRB-
cord-306904-8iteddug	256	26	AIP	AIP	NNP
cord-306904-8iteddug	256	27	)	)	-RRB-
cord-306904-8iteddug	256	28	and	and	CC
cord-306904-8iteddug	256	29	AIP	AIP	NNP
cord-306904-8iteddug	256	30	like	like	IN
cord-306904-8iteddug	256	31	1	1	CD
cord-306904-8iteddug	256	32	(	(	-LRB-
cord-306904-8iteddug	256	33	AIPL1	AIPL1	NNP
cord-306904-8iteddug	256	34	)	)	-RRB-
cord-306904-8iteddug	256	35	.	.	.
cord-306904-8iteddug	257	1	84	84	CD
cord-306904-8iteddug	257	2	AIP	AIP	NNP
cord-306904-8iteddug	257	3	and	and	CC
cord-306904-8iteddug	257	4	AIPL1	AIPL1	NNP
cord-306904-8iteddug	257	5	share	share	NN
cord-306904-8iteddug	257	6	49	49	CD
cord-306904-8iteddug	257	7	%	%	NN
cord-306904-8iteddug	257	8	sequence	sequence	NN
cord-306904-8iteddug	257	9	identity	identity	NN
cord-306904-8iteddug	257	10	,	,	,
cord-306904-8iteddug	257	11	contain	contain	VBP
cord-306904-8iteddug	257	12	an	an	DT
cord-306904-8iteddug	257	13	N	n	CD
cord-306904-8iteddug	257	14	-	-	HYPH
cord-306904-8iteddug	257	15	terminal	terminal	JJ
cord-306904-8iteddug	257	16	FKBP	FKBP	NNP
cord-306904-8iteddug	257	17	-	-	HYPH
cord-306904-8iteddug	257	18	like	like	JJ
cord-306904-8iteddug	257	19	prolyl	prolyl	NNP
cord-306904-8iteddug	257	20	peptidyl	peptidyl	JJ
cord-306904-8iteddug	257	21	isomerase	isomerase	NN
cord-306904-8iteddug	257	22	(	(	-LRB-
cord-306904-8iteddug	257	23	PPIase	PPIase	NNP
cord-306904-8iteddug	257	24	)	)	-RRB-
cord-306904-8iteddug	257	25	domain	domain	NN
cord-306904-8iteddug	257	26	(	(	-LRB-
cord-306904-8iteddug	257	27	which	which	WDT
cord-306904-8iteddug	257	28	is	be	VBZ
cord-306904-8iteddug	257	29	inactive	inactive	JJ
cord-306904-8iteddug	257	30	in	in	IN
cord-306904-8iteddug	257	31	both	both	DT
cord-306904-8iteddug	257	32	proteins	protein	NNS
cord-306904-8iteddug	257	33	)	)	-RRB-
cord-306904-8iteddug	257	34	followed	follow	VBD
cord-306904-8iteddug	257	35	by	by	IN
cord-306904-8iteddug	257	36	a	a	DT
cord-306904-8iteddug	257	37	tetratricopeptide	tetratricopeptide	JJ
cord-306904-8iteddug	257	38	repeat	repeat	NN
cord-306904-8iteddug	257	39	(	(	-LRB-
cord-306904-8iteddug	257	40	TPR	TPR	NNP
cord-306904-8iteddug	257	41	)	)	-RRB-
cord-306904-8iteddug	257	42	domain	domain	NN
cord-306904-8iteddug	257	43	.	.	.
cord-306904-8iteddug	258	1	In	in	IN
cord-306904-8iteddug	258	2	addition	addition	NN
cord-306904-8iteddug	258	3	,	,	,
cord-306904-8iteddug	258	4	AIPL1	AIPL1	NNP
cord-306904-8iteddug	258	5	harbors	harbor	VBZ
cord-306904-8iteddug	258	6	a	a	DT
cord-306904-8iteddug	258	7	unique	unique	JJ
cord-306904-8iteddug	258	8	C	c	NN
cord-306904-8iteddug	258	9	-	-	HYPH
cord-306904-8iteddug	258	10	terminal	terminal	NN
cord-306904-8iteddug	258	11	proline	proline	JJ
cord-306904-8iteddug	258	12	-	-	HYPH
cord-306904-8iteddug	258	13	rich	rich	JJ
cord-306904-8iteddug	258	14	domain	domain	NN
cord-306904-8iteddug	258	15	(	(	-LRB-
cord-306904-8iteddug	258	16	PRD	PRD	NNP
cord-306904-8iteddug	258	17	)	)	-RRB-
cord-306904-8iteddug	258	18	.	.	.
cord-306904-8iteddug	259	1	84	84	CD
cord-306904-8iteddug	260	1	The	the	DT
cord-306904-8iteddug	260	2	authors	author	NNS
cord-306904-8iteddug	260	3	showed	show	VBD
cord-306904-8iteddug	260	4	that	that	IN
cord-306904-8iteddug	260	5	AIP	AIP	NNP
cord-306904-8iteddug	260	6	is	be	VBZ
cord-306904-8iteddug	260	7	inactive	inactive	JJ
cord-306904-8iteddug	260	8	as	as	IN
cord-306904-8iteddug	260	9	a	a	DT
cord-306904-8iteddug	260	10	chaperone	chaperone	NN
cord-306904-8iteddug	260	11	,	,	,
cord-306904-8iteddug	260	12	whereas	whereas	IN
cord-306904-8iteddug	260	13	AIPL1	AIPL1	NNP
cord-306904-8iteddug	260	14	exhibits	exhibit	VBZ
cord-306904-8iteddug	260	15	chaperone	chaperone	NN
cord-306904-8iteddug	260	16	activity	activity	NN
cord-306904-8iteddug	260	17	and	and	CC
cord-306904-8iteddug	260	18	prevents	prevent	VBZ
cord-306904-8iteddug	260	19	the	the	DT
cord-306904-8iteddug	260	20	aggregation	aggregation	NN
cord-306904-8iteddug	260	21	of	of	IN
cord-306904-8iteddug	260	22	non	non	JJ
cord-306904-8iteddug	260	23	-	-	JJ
cord-306904-8iteddug	260	24	native	native	JJ
cord-306904-8iteddug	260	25	proteins	protein	NNS
cord-306904-8iteddug	260	26	,	,	,
cord-306904-8iteddug	260	27	suggesting	suggest	VBG
cord-306904-8iteddug	260	28	that	that	IN
cord-306904-8iteddug	260	29	PRD	PRD	NNP
cord-306904-8iteddug	260	30	is	be	VBZ
cord-306904-8iteddug	260	31	crucial	crucial	JJ
cord-306904-8iteddug	260	32	for	for	IN
cord-306904-8iteddug	260	33	the	the	DT
cord-306904-8iteddug	260	34	chaperone	chaperone	NN
cord-306904-8iteddug	260	35	function	function	NN
cord-306904-8iteddug	260	36	of	of	IN
cord-306904-8iteddug	260	37	this	this	DT
cord-306904-8iteddug	260	38	protein	protein	NN
cord-306904-8iteddug	260	39	providing	provide	VBG
cord-306904-8iteddug	260	40	a	a	DT
cord-306904-8iteddug	260	41	means	means	NN
cord-306904-8iteddug	260	42	for	for	IN
cord-306904-8iteddug	260	43	efficient	efficient	JJ
cord-306904-8iteddug	260	44	binding	binding	NN
cord-306904-8iteddug	260	45	of	of	IN
cord-306904-8iteddug	260	46	AIPL1	aipl1	NN
cord-306904-8iteddug	260	47	to	to	IN
cord-306904-8iteddug	260	48	non	non	JJ
cord-306904-8iteddug	260	49	-	-	JJ
cord-306904-8iteddug	260	50	native	native	JJ
cord-306904-8iteddug	260	51	proteins	protein	NNS
cord-306904-8iteddug	260	52	.	.	.
cord-306904-8iteddug	261	1	84	84	CD
cord-306904-8iteddug	262	1	Since	since	IN
cord-306904-8iteddug	262	2	AIPL1	AIPL1	NNP
cord-306904-8iteddug	262	3	possesses	possess	VBZ
cord-306904-8iteddug	262	4	decreased	decrease	VBN
cord-306904-8iteddug	262	5	affinity	affinity	NN
cord-306904-8iteddug	262	6	to	to	IN
cord-306904-8iteddug	262	7	Hsp90	Hsp90	NNP
cord-306904-8iteddug	262	8	,	,	,
cord-306904-8iteddug	262	9	the	the	DT
cord-306904-8iteddug	262	10	C	C	NNP
cord-306904-8iteddug	262	11	-	-	HYPH
cord-306904-8iteddug	262	12	terminal	terminal	NN
cord-306904-8iteddug	262	13	PRD	PRD	NNP
cord-306904-8iteddug	262	14	plays	play	VBZ
cord-306904-8iteddug	262	15	a	a	DT
cord-306904-8iteddug	262	16	role	role	NN
cord-306904-8iteddug	262	17	of	of	IN
cord-306904-8iteddug	262	18	a	a	DT
cord-306904-8iteddug	262	19	negative	negative	JJ
cord-306904-8iteddug	262	20	regulator	regulator	NN
cord-306904-8iteddug	262	21	of	of	IN
cord-306904-8iteddug	262	22	the	the	DT
cord-306904-8iteddug	262	23	AIPL1-Hsp90	AIPL1-Hsp90	VBN
cord-306904-8iteddug	262	24	interaction	interaction	NN
cord-306904-8iteddug	262	25	.	.	.
cord-306904-8iteddug	263	1	84	84	CD
cord-306904-8iteddug	263	2	Figure	figure	NN
cord-306904-8iteddug	263	3	8A	8a	NN
cord-306904-8iteddug	263	4	shows	show	VBZ
cord-306904-8iteddug	263	5	that	that	IN
cord-306904-8iteddug	263	6	the	the	DT
cord-306904-8iteddug	263	7	major	major	JJ
cord-306904-8iteddug	263	8	portion	portion	NN
cord-306904-8iteddug	263	9	of	of	IN
cord-306904-8iteddug	263	10	the	the	DT
cord-306904-8iteddug	263	11	human	human	JJ
cord-306904-8iteddug	263	12	AIPL1	AIPL1	NNP
cord-306904-8iteddug	263	13	(	(	-LRB-
cord-306904-8iteddug	263	14	N	n	CD
cord-306904-8iteddug	263	15	-	-	HYPH
cord-306904-8iteddug	263	16	terminal	terminal	NN
cord-306904-8iteddug	263	17	75	75	CD
cord-306904-8iteddug	263	18	%	%	NN
cord-306904-8iteddug	263	19	)	)	-RRB-
cord-306904-8iteddug	263	20	containing	contain	VBG
cord-306904-8iteddug	263	21	FKBP	FKBP	NNP
cord-306904-8iteddug	263	22	-	-	HYPH
cord-306904-8iteddug	263	23	like	like	JJ
cord-306904-8iteddug	263	24	prolyl	prolyl	NNP
cord-306904-8iteddug	263	25	peptidyl	peptidyl	JJ
cord-306904-8iteddug	263	26	isomerase	isomerase	NN
cord-306904-8iteddug	263	27	and	and	CC
cord-306904-8iteddug	263	28	TPR	TPR	NNP
cord-306904-8iteddug	263	29	domains	domain	NNS
cord-306904-8iteddug	263	30	is	be	VBZ
cord-306904-8iteddug	263	31	predicted	predict	VBN
cord-306904-8iteddug	263	32	to	to	TO
cord-306904-8iteddug	263	33	be	be	VB
cord-306904-8iteddug	263	34	mostly	mostly	RB
cord-306904-8iteddug	263	35	ordered	order	VBN
cord-306904-8iteddug	264	1	(	(	-LRB-
cord-306904-8iteddug	264	2	UniProt	UniProt	NNP
cord-306904-8iteddug	264	3	ID	ID	NNP
cord-306904-8iteddug	264	4	:	:	:
cord-306904-8iteddug	264	5	Q9NZN9	q9nzn9	NN
cord-306904-8iteddug	264	6	)	)	-RRB-
cord-306904-8iteddug	264	7	,	,	,
cord-306904-8iteddug	264	8	whereas	whereas	IN
cord-306904-8iteddug	264	9	the	the	DT
cord-306904-8iteddug	264	10	C	c	NN
cord-306904-8iteddug	264	11	-	-	HYPH
cord-306904-8iteddug	264	12	terminal	terminal	NN
cord-306904-8iteddug	264	13	domain	domain	NN
cord-306904-8iteddug	264	14	is	be	VBZ
cord-306904-8iteddug	264	15	predicted	predict	VBN
cord-306904-8iteddug	264	16	to	to	TO
cord-306904-8iteddug	264	17	be	be	VB
cord-306904-8iteddug	264	18	highly	highly	RB
cord-306904-8iteddug	264	19	disordered	disordered	JJ
cord-306904-8iteddug	264	20	.	.	.
cord-306904-8iteddug	265	1	On	on	IN
cord-306904-8iteddug	265	2	the	the	DT
cord-306904-8iteddug	265	3	other	other	JJ
cord-306904-8iteddug	265	4	hand	hand	NN
cord-306904-8iteddug	265	5	,	,	,
cord-306904-8iteddug	265	6	Figure	Figure	NNP
cord-306904-8iteddug	265	7	8B	8b	NN
cord-306904-8iteddug	265	8	indicates	indicate	VBZ
cord-306904-8iteddug	265	9	that	that	IN
cord-306904-8iteddug	265	10	the	the	DT
cord-306904-8iteddug	265	11	human	human	JJ
cord-306904-8iteddug	265	12	AIP	aip	NN
cord-306904-8iteddug	265	13	(	(	-LRB-
cord-306904-8iteddug	265	14	UniProt	UniProt	NNP
cord-306904-8iteddug	265	15	ID	ID	NNP
cord-306904-8iteddug	265	16	:	:	:
cord-306904-8iteddug	265	17	O00170	O00170	NNP
cord-306904-8iteddug	265	18	)	)	-RRB-
cord-306904-8iteddug	265	19	is	be	VBZ
cord-306904-8iteddug	265	20	expected	expect	VBN
cord-306904-8iteddug	265	21	to	to	TO
cord-306904-8iteddug	265	22	be	be	VB
cord-306904-8iteddug	265	23	mostly	mostly	RB
cord-306904-8iteddug	265	24	ordered	order	VBN
cord-306904-8iteddug	265	25	.	.	.
cord-306904-8iteddug	266	1	In	in	IN
cord-306904-8iteddug	266	2	agreement	agreement	NN
cord-306904-8iteddug	266	3	with	with	IN
cord-306904-8iteddug	266	4	these	these	DT
cord-306904-8iteddug	266	5	disorder	disorder	NN
cord-306904-8iteddug	266	6	predictions	prediction	NNS
cord-306904-8iteddug	266	7	,	,	,
cord-306904-8iteddug	266	8	3D	3d	JJ
cord-306904-8iteddug	266	9	structures	structure	NNS
cord-306904-8iteddug	266	10	are	be	VBP
cord-306904-8iteddug	266	11	known	know	VBN
cord-306904-8iteddug	266	12	for	for	IN
cord-306904-8iteddug	266	13	the	the	DT
cord-306904-8iteddug	266	14	PPIase	PPIase	NNP
cord-306904-8iteddug	266	15	FKBP	FKBP	NNP
cord-306904-8iteddug	266	16	-	-	HYPH
cord-306904-8iteddug	266	17	type	type	NN
cord-306904-8iteddug	266	18	domain	domain	NN
cord-306904-8iteddug	266	19	of	of	IN
cord-306904-8iteddug	266	20	human	human	JJ
cord-306904-8iteddug	266	21	AIP	aip	NN
cord-306904-8iteddug	266	22	(	(	-LRB-
cord-306904-8iteddug	266	23	residues	residue	NNS
cord-306904-8iteddug	266	24	2	2	CD
cord-306904-8iteddug	266	25	-	-	SYM
cord-306904-8iteddug	266	26	166	166	CD
cord-306904-8iteddug	266	27	,	,	,
cord-306904-8iteddug	266	28	PDB	PDB	NNP
cord-306904-8iteddug	266	29	ID	ID	NNP
cord-306904-8iteddug	266	30	:	:	:
cord-306904-8iteddug	266	31	2LKN	2lkn	LS
cord-306904-8iteddug	266	32	)	)	-RRB-
cord-306904-8iteddug	266	33	and	and	CC
cord-306904-8iteddug	266	34	for	for	IN
cord-306904-8iteddug	266	35	its	-PRON-	PRP$
cord-306904-8iteddug	266	36	TPR	TPR	NNP
cord-306904-8iteddug	266	37	domain	domain	NN
cord-306904-8iteddug	266	38	(	(	-LRB-
cord-306904-8iteddug	266	39	residues	residue	NNS
cord-306904-8iteddug	266	40	173	173	CD
cord-306904-8iteddug	266	41	-	-	SYM
cord-306904-8iteddug	266	42	330	330	CD
cord-306904-8iteddug	266	43	,	,	,
cord-306904-8iteddug	266	44	PDB	PDB	NNP
cord-306904-8iteddug	266	45	ID	ID	NNP
cord-306904-8iteddug	266	46	:	:	:
cord-306904-8iteddug	266	47	4AIF	4aif	CD
cord-306904-8iteddug	266	48	)	)	-RRB-
cord-306904-8iteddug	266	49	.	.	.
cord-306904-8iteddug	267	1	The	the	DT
cord-306904-8iteddug	267	2	intrinsically	intrinsically	RB
cord-306904-8iteddug	267	3	disordered	disordered	JJ
cord-306904-8iteddug	267	4	nature	nature	NN
cord-306904-8iteddug	267	5	of	of	IN
cord-306904-8iteddug	267	6	the	the	DT
cord-306904-8iteddug	267	7	C	C	NNP
cord-306904-8iteddug	267	8	-	-	HYPH
cord-306904-8iteddug	267	9	terminal	terminal	NN
cord-306904-8iteddug	267	10	PRD	PRD	NNP
cord-306904-8iteddug	267	11	of	of	IN
cord-306904-8iteddug	267	12	the	the	DT
cord-306904-8iteddug	267	13	human	human	JJ
cord-306904-8iteddug	267	14	AIPL1	AIPL1	NNP
cord-306904-8iteddug	267	15	possessing	possess	VBG
cord-306904-8iteddug	267	16	chaperone	chaperone	NN
cord-306904-8iteddug	267	17	activity	activity	NN
cord-306904-8iteddug	267	18	is	be	VBZ
cord-306904-8iteddug	267	19	in	in	IN
cord-306904-8iteddug	267	20	accord	accord	NN
cord-306904-8iteddug	267	21	with	with	IN
cord-306904-8iteddug	267	22	earlier	early	JJR
cord-306904-8iteddug	267	23	observations	observation	NNS
cord-306904-8iteddug	267	24	that	that	IN
cord-306904-8iteddug	267	25	chaperones	chaperone	NNS
cord-306904-8iteddug	267	26	are	be	VBP
cord-306904-8iteddug	267	27	often	often	RB
cord-306904-8iteddug	267	28	either	either	CC
cord-306904-8iteddug	267	29	entirely	entirely	RB
cord-306904-8iteddug	267	30	disordered	disordered	JJ
cord-306904-8iteddug	267	31	or	or	CC
cord-306904-8iteddug	267	32	contain	contain	VBP
cord-306904-8iteddug	267	33	long	long	JJ
cord-306904-8iteddug	267	34	disordered	disordered	JJ
cord-306904-8iteddug	267	35	regions	region	NNS
cord-306904-8iteddug	267	36	.	.	.
cord-306904-8iteddug	268	1	72	72	CD
cord-306904-8iteddug	268	2	,	,	,
cord-306904-8iteddug	268	3	85	85	CD
cord-306904-8iteddug	268	4	Basic	basic	JJ
cord-306904-8iteddug	268	5	residues	residue	NNS
cord-306904-8iteddug	268	6	in	in	IN
cord-306904-8iteddug	268	7	the	the	DT
cord-306904-8iteddug	268	8	activated	activate	VBN
cord-306904-8iteddug	268	9	protein	protein	NN
cord-306904-8iteddug	268	10	C	C	NNP
cord-306904-8iteddug	268	11	(	(	-LRB-
cord-306904-8iteddug	268	12	APC	APC	NNP
cord-306904-8iteddug	268	13	)	)	-RRB-
cord-306904-8iteddug	268	14	exosite	exosite	NNP
cord-306904-8iteddug	268	15	Takeyama	Takeyama	NNP
cord-306904-8iteddug	268	16	et	et	FW
cord-306904-8iteddug	268	17	al	al	NNP
cord-306904-8iteddug	268	18	.	.	NNP
cord-306904-8iteddug	268	19	provided	provide	VBD
cord-306904-8iteddug	268	20	a	a	DT
cord-306904-8iteddug	268	21	detailed	detailed	JJ
cord-306904-8iteddug	268	22	description	description	NN
cord-306904-8iteddug	268	23	of	of	IN
cord-306904-8iteddug	268	24	the	the	DT
cord-306904-8iteddug	268	25	interaction	interaction	NN
cord-306904-8iteddug	268	26	between	between	IN
cord-306904-8iteddug	268	27	the	the	DT
cord-306904-8iteddug	268	28	activated	activate	VBN
cord-306904-8iteddug	268	29	protein	protein	NN
cord-306904-8iteddug	268	30	C	C	NNP
cord-306904-8iteddug	268	31	(	(	-LRB-
cord-306904-8iteddug	268	32	APC	APC	NNP
cord-306904-8iteddug	268	33	)	)	-RRB-
cord-306904-8iteddug	268	34	and	and	CC
cord-306904-8iteddug	268	35	factor	factor	NN
cord-306904-8iteddug	268	36	(	(	-LRB-
cord-306904-8iteddug	268	37	F	F	NNP
cord-306904-8iteddug	268	38	)	)	-RRB-
cord-306904-8iteddug	268	39	VIIIa	VIIIa	NNS
cord-306904-8iteddug	268	40	.	.	.
cord-306904-8iteddug	269	1	86	86	CD
cord-306904-8iteddug	270	1	The	the	DT
cord-306904-8iteddug	270	2	authors	author	NNS
cord-306904-8iteddug	270	3	showed	show	VBD
cord-306904-8iteddug	270	4	that	that	IN
cord-306904-8iteddug	270	5	the	the	DT
cord-306904-8iteddug	270	6	basic	basic	JJ
cord-306904-8iteddug	270	7	residues	residue	NNS
cord-306904-8iteddug	270	8	located	locate	VBN
cord-306904-8iteddug	270	9	within	within	IN
cord-306904-8iteddug	270	10	the	the	DT
cord-306904-8iteddug	270	11	39-	39-	NNP
cord-306904-8iteddug	270	12	,	,	,
cord-306904-8iteddug	270	13	60-	60-	NNP
cord-306904-8iteddug	270	14	,	,	,
cord-306904-8iteddug	270	15	and	and	CC
cord-306904-8iteddug	270	16	70	70	CD
cord-306904-8iteddug	270	17	-	-	SYM
cord-306904-8iteddug	270	18	80-loops	80-loops	CD
cord-306904-8iteddug	270	19	of	of	IN
cord-306904-8iteddug	270	20	APC	APC	NNP
cord-306904-8iteddug	270	21	constitutes	constitute	VBZ
cord-306904-8iteddug	270	22	an	an	DT
cord-306904-8iteddug	270	23	exosite	exosite	NN
cord-306904-8iteddug	270	24	that	that	WDT
cord-306904-8iteddug	270	25	contributes	contribute	VBZ
cord-306904-8iteddug	270	26	to	to	IN
cord-306904-8iteddug	270	27	the	the	DT
cord-306904-8iteddug	270	28	binding	binding	NN
cord-306904-8iteddug	270	29	of	of	IN
cord-306904-8iteddug	270	30	FVIII	FVIII	NNP
cord-306904-8iteddug	270	31	and	and	CC
cord-306904-8iteddug	270	32	therefore	therefore	RB
cord-306904-8iteddug	270	33	are	be	VBP
cord-306904-8iteddug	270	34	important	important	JJ
cord-306904-8iteddug	270	35	for	for	IN
cord-306904-8iteddug	270	36	the	the	DT
cord-306904-8iteddug	270	37	subsequent	subsequent	JJ
cord-306904-8iteddug	270	38	proteolytic	proteolytic	JJ
cord-306904-8iteddug	270	39	inactivation	inactivation	NN
cord-306904-8iteddug	270	40	of	of	IN
cord-306904-8iteddug	270	41	FVIII	FVIII	NNP
cord-306904-8iteddug	270	42	.	.	.
cord-306904-8iteddug	271	1	86	86	CD
cord-306904-8iteddug	271	2	APC	APC	NNP
cord-306904-8iteddug	271	3	,	,	,
cord-306904-8iteddug	271	4	which	which	WDT
cord-306904-8iteddug	271	5	is	be	VBZ
cord-306904-8iteddug	271	6	also	also	RB
cord-306904-8iteddug	271	7	known	know	VBN
cord-306904-8iteddug	271	8	as	as	IN
cord-306904-8iteddug	271	9	vitamin	vitamin	NN
cord-306904-8iteddug	271	10	K	k	NN
cord-306904-8iteddug	271	11	-	-	HYPH
cord-306904-8iteddug	271	12	dependent	dependent	JJ
cord-306904-8iteddug	271	13	protein	protein	NN
cord-306904-8iteddug	271	14	C	c	NN
cord-306904-8iteddug	271	15	,	,	,
cord-306904-8iteddug	271	16	anticoagulant	anticoagulant	NN
cord-306904-8iteddug	271	17	protein	protein	NN
cord-306904-8iteddug	271	18	C	C	NNP
cord-306904-8iteddug	271	19	,	,	,
cord-306904-8iteddug	271	20	autoprothrombin	autoprothrombin	NNP
cord-306904-8iteddug	271	21	IIA	IIA	NNP
cord-306904-8iteddug	271	22	,	,	,
cord-306904-8iteddug	271	23	and	and	CC
cord-306904-8iteddug	271	24	blood	blood	NN
cord-306904-8iteddug	271	25	coagulation	coagulation	NN
cord-306904-8iteddug	271	26	factor	factor	NN
cord-306904-8iteddug	272	1	XIV	XIV	NNP
cord-306904-8iteddug	272	2	,	,	,
cord-306904-8iteddug	272	3	is	be	VBZ
cord-306904-8iteddug	272	4	a	a	DT
cord-306904-8iteddug	272	5	single	single	JJ
cord-306904-8iteddug	272	6	chain	chain	NN
cord-306904-8iteddug	272	7	vitamin	vitamin	NN
cord-306904-8iteddug	272	8	K	k	NN
cord-306904-8iteddug	272	9	-	-	HYPH
cord-306904-8iteddug	272	10	dependent	dependent	JJ
cord-306904-8iteddug	272	11	zymogen	zymogen	NNP
cord-306904-8iteddug	272	12	for	for	IN
cord-306904-8iteddug	272	13	a	a	DT
cord-306904-8iteddug	272	14	plasma	plasma	NN
cord-306904-8iteddug	272	15	serine	serine	NN
cord-306904-8iteddug	272	16	protease	protease	NN
cord-306904-8iteddug	272	17	that	that	WDT
cord-306904-8iteddug	272	18	upon	upon	IN
cord-306904-8iteddug	272	19	activation	activation	NN
cord-306904-8iteddug	272	20	by	by	IN
cord-306904-8iteddug	272	21	the	the	DT
cord-306904-8iteddug	272	22	thrombin	thrombin	NN
cord-306904-8iteddug	272	23	-	-	HYPH
cord-306904-8iteddug	272	24	thrombomodulin	thrombomodulin	NNP
cord-306904-8iteddug	272	25	complex	complex	NN
cord-306904-8iteddug	272	26	down	down	RP
cord-306904-8iteddug	272	27	regulates	regulate	VBZ
cord-306904-8iteddug	272	28	the	the	DT
cord-306904-8iteddug	272	29	coagulation	coagulation	NN
cord-306904-8iteddug	272	30	cascade	cascade	NN
cord-306904-8iteddug	272	31	by	by	IN
cord-306904-8iteddug	272	32	limited	limited	JJ
cord-306904-8iteddug	272	33	proteolysis	proteolysis	NN
cord-306904-8iteddug	272	34	of	of	IN
cord-306904-8iteddug	272	35	FVa	FVa	NNS
cord-306904-8iteddug	272	36	and	and	CC
cord-306904-8iteddug	272	37	FVIIIa	FVIIIa	NNS
cord-306904-8iteddug	272	38	.	.	.
cord-306904-8iteddug	273	1	[	[	-LRB-
cord-306904-8iteddug	273	2	87	87	CD
cord-306904-8iteddug	273	3	]	]	-RRB-
cord-306904-8iteddug	273	4	[	[	-LRB-
cord-306904-8iteddug	273	5	88	88	CD
cord-306904-8iteddug	273	6	]	]	-RRB-
cord-306904-8iteddug	274	1	[	[	-LRB-
cord-306904-8iteddug	274	2	89	89	CD
cord-306904-8iteddug	274	3	]	]	-RRB-
cord-306904-8iteddug	274	4	Analysis	Analysis	NNP
cord-306904-8iteddug	274	5	of	of	IN
cord-306904-8iteddug	274	6	the	the	DT
cord-306904-8iteddug	274	7	crystal	crystal	JJ
cord-306904-8iteddug	274	8	structure	structure	NN
cord-306904-8iteddug	274	9	of	of	IN
cord-306904-8iteddug	274	10	human	human	JJ
cord-306904-8iteddug	274	11	APC	APC	NNP
cord-306904-8iteddug	274	12	(	(	-LRB-
cord-306904-8iteddug	274	13	PDB	PDB	NNP
cord-306904-8iteddug	274	14	ID	ID	NNP
cord-306904-8iteddug	274	15	:	:	:
cord-306904-8iteddug	274	16	1AUT	1aut	LS
cord-306904-8iteddug	274	17	)	)	-RRB-
cord-306904-8iteddug	274	18	revealed	reveal	VBD
cord-306904-8iteddug	274	19	that	that	IN
cord-306904-8iteddug	274	20	there	there	EX
cord-306904-8iteddug	274	21	are	be	VBP
cord-306904-8iteddug	274	22	3	3	CD
cord-306904-8iteddug	274	23	surface	surface	NN
cord-306904-8iteddug	274	24	loops	loop	NNS
cord-306904-8iteddug	274	25	(	(	-LRB-
cord-306904-8iteddug	274	26	39	39	CD
cord-306904-8iteddug	274	27	,	,	,
cord-306904-8iteddug	274	28	60	60	CD
cord-306904-8iteddug	274	29	,	,	,
cord-306904-8iteddug	274	30	and	and	CC
cord-306904-8iteddug	274	31	70	70	CD
cord-306904-8iteddug	274	32	-	-	SYM
cord-306904-8iteddug	274	33	80	80	CD
cord-306904-8iteddug	274	34	)	)	-RRB-
cord-306904-8iteddug	274	35	,	,	,
cord-306904-8iteddug	274	36	rich	rich	JJ
cord-306904-8iteddug	274	37	in	in	IN
cord-306904-8iteddug	274	38	basic	basic	JJ
cord-306904-8iteddug	274	39	residues	residue	NNS
cord-306904-8iteddug	274	40	,	,	,
cord-306904-8iteddug	274	41	located	locate	VBN
cord-306904-8iteddug	274	42	in	in	IN
cord-306904-8iteddug	274	43	the	the	DT
cord-306904-8iteddug	274	44	protease	protease	NN
cord-306904-8iteddug	274	45	domain	domain	NN
cord-306904-8iteddug	274	46	of	of	IN
cord-306904-8iteddug	274	47	APC	APC	NNP
cord-306904-8iteddug	274	48	near	near	IN
cord-306904-8iteddug	274	49	the	the	DT
cord-306904-8iteddug	274	50	active	active	JJ
cord-306904-8iteddug	274	51	site	site	NN
cord-306904-8iteddug	274	52	pocket	pocket	NN
cord-306904-8iteddug	274	53	.	.	.
cord-306904-8iteddug	275	1	86	86	CD
cord-306904-8iteddug	275	2	,	,	,
cord-306904-8iteddug	275	3	90	90	CD
cord-306904-8iteddug	275	4	FVIIIa	FVIIIa	NNS
cord-306904-8iteddug	275	5	contains	contain	VBZ
cord-306904-8iteddug	275	6	acidic	acidic	JJ
cord-306904-8iteddug	275	7	C	c	NN
cord-306904-8iteddug	275	8	-	-	HYPH
cord-306904-8iteddug	275	9	terminal	terminal	NN
cord-306904-8iteddug	275	10	sequences	sequence	NNS
cord-306904-8iteddug	275	11	that	that	WDT
cord-306904-8iteddug	275	12	may	may	MD
cord-306904-8iteddug	275	13	potentially	potentially	RB
cord-306904-8iteddug	275	14	provide	provide	VB
cord-306904-8iteddug	275	15	interactive	interactive	JJ
cord-306904-8iteddug	275	16	sites	site	NNS
cord-306904-8iteddug	275	17	for	for	IN
cord-306904-8iteddug	275	18	the	the	DT
cord-306904-8iteddug	275	19	basic	basic	JJ
cord-306904-8iteddug	275	20	exosite	exosite	NN
cord-306904-8iteddug	275	21	of	of	IN
cord-306904-8iteddug	275	22	APC	APC	NNP
cord-306904-8iteddug	275	23	.	.	.
cord-306904-8iteddug	276	1	86	86	CD
cord-306904-8iteddug	276	2	Figure	figure	NN
cord-306904-8iteddug	276	3	8C	8c	CD
cord-306904-8iteddug	276	4	represents	represent	VBZ
cord-306904-8iteddug	276	5	the	the	DT
cord-306904-8iteddug	276	6	results	result	NNS
cord-306904-8iteddug	276	7	of	of	IN
cord-306904-8iteddug	276	8	the	the	DT
cord-306904-8iteddug	276	9	computational	computational	JJ
cord-306904-8iteddug	276	10	disorder	disorder	NN
cord-306904-8iteddug	276	11	analysis	analysis	NN
cord-306904-8iteddug	276	12	in	in	IN
cord-306904-8iteddug	276	13	human	human	JJ
cord-306904-8iteddug	276	14	APC	APC	NNP
cord-306904-8iteddug	276	15	(	(	-LRB-
cord-306904-8iteddug	276	16	UniProt	UniProt	NNP
cord-306904-8iteddug	276	17	ID	ID	NNP
cord-306904-8iteddug	276	18	:	:	:
cord-306904-8iteddug	276	19	P04070	P04070	NNP
cord-306904-8iteddug	276	20	)	)	-RRB-
cord-306904-8iteddug	276	21	and	and	CC
cord-306904-8iteddug	276	22	shows	show	VBZ
cord-306904-8iteddug	276	23	that	that	WDT
cord-306904-8iteddug	276	24	mentioned	mention	VBD
cord-306904-8iteddug	276	25	loops	loop	NNS
cord-306904-8iteddug	276	26	enriched	enrich	VBN
cord-306904-8iteddug	276	27	in	in	IN
cord-306904-8iteddug	276	28	basic	basic	JJ
cord-306904-8iteddug	276	29	residues	residue	NNS
cord-306904-8iteddug	276	30	are	be	VBP
cord-306904-8iteddug	276	31	predicted	predict	VBN
cord-306904-8iteddug	276	32	to	to	TO
cord-306904-8iteddug	276	33	be	be	VB
cord-306904-8iteddug	276	34	disordered	disordered	JJ
cord-306904-8iteddug	276	35	or	or	CC
cord-306904-8iteddug	276	36	very	very	RB
cord-306904-8iteddug	276	37	flexible	flexible	JJ
cord-306904-8iteddug	276	38	,	,	,
cord-306904-8iteddug	276	39	thereby	thereby	RB
cord-306904-8iteddug	276	40	providing	provide	VBG
cord-306904-8iteddug	276	41	an	an	DT
cord-306904-8iteddug	276	42	interesting	interesting	JJ
cord-306904-8iteddug	276	43	mechanistic	mechanistic	JJ
cord-306904-8iteddug	276	44	plane	plane	NN
cord-306904-8iteddug	276	45	for	for	IN
cord-306904-8iteddug	276	46	the	the	DT
cord-306904-8iteddug	276	47	molecular	molecular	JJ
cord-306904-8iteddug	276	48	basis	basis	NN
cord-306904-8iteddug	276	49	of	of	IN
cord-306904-8iteddug	276	50	APC	APC	NNP
cord-306904-8iteddug	276	51	recognition	recognition	NN
cord-306904-8iteddug	276	52	and	and	CC
cord-306904-8iteddug	276	53	binding	binding	NN
cord-306904-8iteddug	276	54	of	of	IN
cord-306904-8iteddug	276	55	FVIII	FVIII	NNP
cord-306904-8iteddug	276	56	.	.	.
cord-306904-8iteddug	277	1	The	the	DT
cord-306904-8iteddug	277	2	Escherichia	Escherichia	NNP
cord-306904-8iteddug	277	3	coli	coli	NNS
cord-306904-8iteddug	277	4	primosomal	primosomal	VBN
cord-306904-8iteddug	277	5	DnaT	DnaT	NNP
cord-306904-8iteddug	277	6	protein	protein	NN
cord-306904-8iteddug	277	7	Molecular	Molecular	NNP
cord-306904-8iteddug	277	8	mechanisms	mechanism	NNS
cord-306904-8iteddug	277	9	of	of	IN
cord-306904-8iteddug	277	10	the	the	DT
cord-306904-8iteddug	277	11	oligomerization	oligomerization	NN
cord-306904-8iteddug	277	12	of	of	IN
cord-306904-8iteddug	277	13	E.coli	E.coli	NNS
cord-306904-8iteddug	277	14	primosomal	primosomal	VBN
cord-306904-8iteddug	277	15	DnaT	DnaT	NNP
cord-306904-8iteddug	277	16	protein	protein	NN
cord-306904-8iteddug	277	17	are	be	VBP
cord-306904-8iteddug	277	18	uncovered	uncover	VBN
cord-306904-8iteddug	277	19	in	in	IN
cord-306904-8iteddug	277	20	the	the	DT
cord-306904-8iteddug	277	21	study	study	NN
cord-306904-8iteddug	277	22	by	by	IN
cord-306904-8iteddug	277	23	Szymanski	Szymanski	NNP
cord-306904-8iteddug	277	24	et	et	NNP
cord-306904-8iteddug	277	25	al	al	NNP
cord-306904-8iteddug	277	26	.	.	.
cord-306904-8iteddug	278	1	91	91	CD
cord-306904-8iteddug	279	1	The	the	DT
cord-306904-8iteddug	279	2	authors	author	NNS
cord-306904-8iteddug	279	3	showed	show	VBD
cord-306904-8iteddug	279	4	that	that	IN
cord-306904-8iteddug	279	5	the	the	DT
cord-306904-8iteddug	279	6	removal	removal	NN
cord-306904-8iteddug	279	7	of	of	IN
cord-306904-8iteddug	279	8	the	the	DT
cord-306904-8iteddug	279	9	short	short	JJ
cord-306904-8iteddug	279	10	C	C	NNP
cord-306904-8iteddug	279	11	-	-	HYPH
cord-306904-8iteddug	279	12	terminal	terminal	NN
cord-306904-8iteddug	279	13	region	region	NN
cord-306904-8iteddug	279	14	dramatically	dramatically	RB
cord-306904-8iteddug	279	15	affects	affect	VBZ
cord-306904-8iteddug	279	16	the	the	DT
cord-306904-8iteddug	279	17	oligomerization	oligomerization	NN
cord-306904-8iteddug	279	18	process	process	NN
cord-306904-8iteddug	279	19	and	and	CC
cord-306904-8iteddug	279	20	instead	instead	RB
cord-306904-8iteddug	279	21	of	of	IN
cord-306904-8iteddug	279	22	the	the	DT
cord-306904-8iteddug	279	23	trimer	trimer	NN
cord-306904-8iteddug	279	24	,	,	,
cord-306904-8iteddug	279	25	the	the	DT
cord-306904-8iteddug	279	26	isolated	isolated	JJ
cord-306904-8iteddug	279	27	N	n	CD
cord-306904-8iteddug	279	28	-	-	HYPH
cord-306904-8iteddug	279	29	terminal	terminal	NN
cord-306904-8iteddug	279	30	domain	domain	NN
cord-306904-8iteddug	279	31	of	of	IN
cord-306904-8iteddug	279	32	DnaT	DnaT	NNP
cord-306904-8iteddug	279	33	forms	form	VBZ
cord-306904-8iteddug	279	34	a	a	DT
cord-306904-8iteddug	279	35	dimer	dimer	NN
cord-306904-8iteddug	279	36	.	.	.
cord-306904-8iteddug	280	1	91	91	CD
cord-306904-8iteddug	280	2	Priming	priming	NN
cord-306904-8iteddug	280	3	of	of	IN
cord-306904-8iteddug	280	4	the	the	DT
cord-306904-8iteddug	280	5	DNA	dna	NN
cord-306904-8iteddug	280	6	strand	strand	NN
cord-306904-8iteddug	280	7	during	during	IN
cord-306904-8iteddug	280	8	the	the	DT
cord-306904-8iteddug	280	9	replication	replication	NN
cord-306904-8iteddug	280	10	process	process	NN
cord-306904-8iteddug	280	11	is	be	VBZ
cord-306904-8iteddug	280	12	catalyzed	catalyze	VBN
cord-306904-8iteddug	280	13	by	by	IN
cord-306904-8iteddug	280	14	a	a	DT
cord-306904-8iteddug	280	15	multiprotein	multiprotein	JJ
cord-306904-8iteddug	280	16	-	-	HYPH
cord-306904-8iteddug	280	17	DNA	dna	NN
cord-306904-8iteddug	280	18	complex	complex	NN
cord-306904-8iteddug	280	19	known	know	VBN
cord-306904-8iteddug	280	20	as	as	IN
cord-306904-8iteddug	280	21	the	the	DT
cord-306904-8iteddug	280	22	primosome	primosome	NN
cord-306904-8iteddug	280	23	.	.	.
cord-306904-8iteddug	281	1	92	92	CD
cord-306904-8iteddug	281	2	,	,	,
cord-306904-8iteddug	281	3	93	93	CD
cord-306904-8iteddug	282	1	The	the	DT
cord-306904-8iteddug	282	2	translocation	translocation	NN
cord-306904-8iteddug	282	3	of	of	IN
cord-306904-8iteddug	282	4	this	this	DT
cord-306904-8iteddug	282	5	complex	complex	NN
cord-306904-8iteddug	282	6	along	along	IN
cord-306904-8iteddug	282	7	the	the	DT
cord-306904-8iteddug	282	8	DNA	dna	NN
cord-306904-8iteddug	282	9	is	be	VBZ
cord-306904-8iteddug	282	10	fueled	fuel	VBN
cord-306904-8iteddug	282	11	by	by	IN
cord-306904-8iteddug	282	12	NTP	NTP	NNP
cord-306904-8iteddug	282	13	hydrolysis	hydrolysis	NN
cord-306904-8iteddug	282	14	.	.	.
cord-306904-8iteddug	283	1	Besides	besides	IN
cord-306904-8iteddug	283	2	being	be	VBG
cord-306904-8iteddug	283	3	responsible	responsible	JJ
cord-306904-8iteddug	283	4	for	for	IN
cord-306904-8iteddug	283	5	the	the	DT
cord-306904-8iteddug	283	6	synthesis	synthesis	NN
cord-306904-8iteddug	283	7	of	of	IN
cord-306904-8iteddug	283	8	short	short	JJ
cord-306904-8iteddug	283	9	oligoribonucleotide	oligoribonucleotide	NN
cord-306904-8iteddug	283	10	primers	primer	NNS
cord-306904-8iteddug	283	11	used	use	VBN
cord-306904-8iteddug	283	12	to	to	TO
cord-306904-8iteddug	283	13	initiate	initiate	VB
cord-306904-8iteddug	283	14	synthesis	synthesis	NN
cord-306904-8iteddug	283	15	of	of	IN
cord-306904-8iteddug	283	16	the	the	DT
cord-306904-8iteddug	283	17	cDNA	cDNA	NNP
cord-306904-8iteddug	283	18	strand	strand	NN
cord-306904-8iteddug	283	19	,	,	,
cord-306904-8iteddug	283	20	primosome	primosome	NNP
cord-306904-8iteddug	283	21	plays	play	VBZ
cord-306904-8iteddug	283	22	a	a	DT
cord-306904-8iteddug	283	23	role	role	NN
cord-306904-8iteddug	283	24	in	in	IN
cord-306904-8iteddug	283	25	the	the	DT
cord-306904-8iteddug	283	26	restarting	restarting	NN
cord-306904-8iteddug	283	27	of	of	IN
cord-306904-8iteddug	283	28	the	the	DT
cord-306904-8iteddug	283	29	stalled	stall	VBN
cord-306904-8iteddug	283	30	replication	replication	NN
cord-306904-8iteddug	283	31	fork	fork	NN
cord-306904-8iteddug	283	32	at	at	IN
cord-306904-8iteddug	283	33	the	the	DT
cord-306904-8iteddug	283	34	damaged	damage	VBN
cord-306904-8iteddug	283	35	DNA	dna	NN
cord-306904-8iteddug	283	36	sites	site	NNS
cord-306904-8iteddug	283	37	.	.	.
cord-306904-8iteddug	284	1	93	93	CD
cord-306904-8iteddug	284	2	,	,	,
cord-306904-8iteddug	284	3	94	94	CD
cord-306904-8iteddug	285	1	The	the	DT
cord-306904-8iteddug	285	2	assembly	assembly	NN
cord-306904-8iteddug	285	3	of	of	IN
cord-306904-8iteddug	285	4	the	the	DT
cord-306904-8iteddug	285	5	primosome	primosome	NN
cord-306904-8iteddug	285	6	is	be	VBZ
cord-306904-8iteddug	285	7	driven	drive	VBN
cord-306904-8iteddug	285	8	by	by	IN
cord-306904-8iteddug	285	9	an	an	DT
cord-306904-8iteddug	285	10	essential	essential	JJ
cord-306904-8iteddug	285	11	replication	replication	NN
cord-306904-8iteddug	285	12	protein	protein	NN
cord-306904-8iteddug	285	13	in	in	IN
cord-306904-8iteddug	285	14	Escherichia	Escherichia	NNP
cord-306904-8iteddug	285	15	coli	coli	NNS
cord-306904-8iteddug	285	16	,	,	,
cord-306904-8iteddug	285	17	the	the	DT
cord-306904-8iteddug	285	18	DnaT	DnaT	NNP
cord-306904-8iteddug	285	19	protein	protein	NN
cord-306904-8iteddug	285	20	,	,	,
cord-306904-8iteddug	285	21	where	where	WRB
cord-306904-8iteddug	285	22	,	,	,
cord-306904-8iteddug	285	23	the	the	DT
cord-306904-8iteddug	285	24	primosome	primosome	NNP
cord-306904-8iteddug	285	25	assembly	assembly	NNP
cord-306904-8iteddug	285	26	is	be	VBZ
cord-306904-8iteddug	285	27	initiated	initiate	VBN
cord-306904-8iteddug	285	28	by	by	IN
cord-306904-8iteddug	285	29	recognition	recognition	NN
cord-306904-8iteddug	285	30	of	of	IN
cord-306904-8iteddug	285	31	a	a	DT
cord-306904-8iteddug	285	32	specific	specific	JJ
cord-306904-8iteddug	285	33	primosome	primosome	NN
cord-306904-8iteddug	285	34	assembly	assembly	NN
cord-306904-8iteddug	285	35	site	site	NN
cord-306904-8iteddug	285	36	(	(	-LRB-
cord-306904-8iteddug	285	37	PAS	pas	NN
cord-306904-8iteddug	285	38	)	)	-RRB-
cord-306904-8iteddug	285	39	of	of	IN
cord-306904-8iteddug	285	40	the	the	DT
cord-306904-8iteddug	285	41	replicating	replicate	VBG
cord-306904-8iteddug	285	42	DNA	dna	NN
cord-306904-8iteddug	285	43	or	or	CC
cord-306904-8iteddug	285	44	the	the	DT
cord-306904-8iteddug	285	45	damaged	damage	VBN
cord-306904-8iteddug	285	46	DNA	dna	NN
cord-306904-8iteddug	285	47	site	site	NN
cord-306904-8iteddug	285	48	by	by	IN
cord-306904-8iteddug	285	49	the	the	DT
cord-306904-8iteddug	285	50	PriA	PriA	NNP
cord-306904-8iteddug	285	51	protein	protein	NN
cord-306904-8iteddug	285	52	,	,	,
cord-306904-8iteddug	285	53	or	or	CC
cord-306904-8iteddug	285	54	the	the	DT
cord-306904-8iteddug	285	55	PriB	PriB	NNP
cord-306904-8iteddug	285	56	protein	protein	NN
cord-306904-8iteddug	285	57	-	-	HYPH
cord-306904-8iteddug	285	58	PriA	PriA	NNP
cord-306904-8iteddug	285	59	complex	complex	NN
cord-306904-8iteddug	285	60	,	,	,
cord-306904-8iteddug	285	61	followed	follow	VBN
cord-306904-8iteddug	285	62	by	by	IN
cord-306904-8iteddug	285	63	the	the	DT
cord-306904-8iteddug	285	64	association	association	NN
cord-306904-8iteddug	285	65	of	of	IN
cord-306904-8iteddug	285	66	the	the	DT
cord-306904-8iteddug	285	67	DnaT	DnaT	NNP
cord-306904-8iteddug	285	68	and	and	CC
cord-306904-8iteddug	285	69	the	the	DT
cord-306904-8iteddug	285	70	PriC	PriC	NNP
cord-306904-8iteddug	285	71	protein	protein	NN
cord-306904-8iteddug	285	72	.	.	.
cord-306904-8iteddug	286	1	[	[	-LRB-
cord-306904-8iteddug	286	2	92	92	CD
cord-306904-8iteddug	286	3	]	]	-RRB-
cord-306904-8iteddug	286	4	[	[	-LRB-
cord-306904-8iteddug	286	5	93	93	CD
cord-306904-8iteddug	286	6	]	]	-RRB-
cord-306904-8iteddug	287	1	[	[	-LRB-
cord-306904-8iteddug	287	2	94	94	CD
cord-306904-8iteddug	287	3	]	]	-RRB-
cord-306904-8iteddug	288	1	This	this	DT
cord-306904-8iteddug	288	2	primary	primary	JJ
cord-306904-8iteddug	288	3	DNA	dna	NN
cord-306904-8iteddug	288	4	-	-	HYPH
cord-306904-8iteddug	288	5	protein	protein	NN
cord-306904-8iteddug	288	6	complex	complex	NN
cord-306904-8iteddug	288	7	is	be	VBZ
cord-306904-8iteddug	288	8	a	a	DT
cord-306904-8iteddug	288	9	scaffold	scaffold	NN
cord-306904-8iteddug	288	10	,	,	,
cord-306904-8iteddug	288	11	specifically	specifically	RB
cord-306904-8iteddug	288	12	recognized	recognize	VBN
cord-306904-8iteddug	288	13	by	by	IN
cord-306904-8iteddug	288	14	the	the	DT
cord-306904-8iteddug	288	15	DnaB	DnaB	NNP
cord-306904-8iteddug	288	16	helicase	helicase	NN
cord-306904-8iteddug	288	17	-	-	HYPH
cord-306904-8iteddug	288	18	DnaC	dnac	NN
cord-306904-8iteddug	288	19	protein	protein	NN
cord-306904-8iteddug	288	20	complex	complex	NN
cord-306904-8iteddug	288	21	,	,	,
cord-306904-8iteddug	288	22	which	which	WDT
cord-306904-8iteddug	288	23	results	result	VBZ
cord-306904-8iteddug	288	24	in	in	IN
cord-306904-8iteddug	288	25	formation	formation	NN
cord-306904-8iteddug	288	26	of	of	IN
cord-306904-8iteddug	288	27	the	the	DT
cord-306904-8iteddug	288	28	preprimosome	preprimosome	NN
cord-306904-8iteddug	288	29	.	.	.
cord-306904-8iteddug	289	1	Next	next	RB
cord-306904-8iteddug	289	2	,	,	,
cord-306904-8iteddug	289	3	the	the	DT
cord-306904-8iteddug	289	4	preprimosome	preprimosome	NN
cord-306904-8iteddug	289	5	is	be	VBZ
cord-306904-8iteddug	289	6	recognized	recognize	VBN
cord-306904-8iteddug	289	7	by	by	IN
cord-306904-8iteddug	289	8	the	the	DT
cord-306904-8iteddug	289	9	primase	primase	NN
cord-306904-8iteddug	289	10	,	,	,
cord-306904-8iteddug	289	11	and	and	CC
cord-306904-8iteddug	289	12	a	a	DT
cord-306904-8iteddug	289	13	functional	functional	JJ
cord-306904-8iteddug	289	14	primosome	primosome	NN
cord-306904-8iteddug	289	15	is	be	VBZ
cord-306904-8iteddug	289	16	formed	form	VBN
cord-306904-8iteddug	289	17	.	.	.
cord-306904-8iteddug	290	1	The	the	DT
cord-306904-8iteddug	290	2	DnaT	DnaT	NNP
cord-306904-8iteddug	290	3	protein	protein	NN
cord-306904-8iteddug	290	4	is	be	VBZ
cord-306904-8iteddug	290	5	crucial	crucial	JJ
cord-306904-8iteddug	290	6	for	for	IN
cord-306904-8iteddug	290	7	the	the	DT
cord-306904-8iteddug	290	8	specific	specific	JJ
cord-306904-8iteddug	290	9	entry	entry	NN
cord-306904-8iteddug	290	10	of	of	IN
cord-306904-8iteddug	290	11	the	the	DT
cord-306904-8iteddug	290	12	DnaB	DnaB	NNP
cord-306904-8iteddug	290	13	helicase	helicase	NN
cord-306904-8iteddug	290	14	into	into	IN
cord-306904-8iteddug	290	15	the	the	DT
cord-306904-8iteddug	290	16	primosome	primosome	NN
cord-306904-8iteddug	290	17	complex	complex	NN
cord-306904-8iteddug	290	18	.	.	.
cord-306904-8iteddug	291	1	[	[	-LRB-
cord-306904-8iteddug	291	2	92	92	CD
cord-306904-8iteddug	291	3	]	]	-RRB-
cord-306904-8iteddug	291	4	[	[	-LRB-
cord-306904-8iteddug	291	5	93	93	CD
cord-306904-8iteddug	291	6	]	]	-RRB-
cord-306904-8iteddug	292	1	[	[	-LRB-
cord-306904-8iteddug	292	2	94	94	CD
cord-306904-8iteddug	292	3	]	]	-RRB-
cord-306904-8iteddug	293	1	The	the	DT
cord-306904-8iteddug	293	2	DnaT	DnaT	NNP
cord-306904-8iteddug	293	3	monomer	monomer	NN
cord-306904-8iteddug	293	4	consists	consist	VBZ
cord-306904-8iteddug	293	5	of	of	IN
cord-306904-8iteddug	293	6	the	the	DT
cord-306904-8iteddug	293	7	large	large	JJ
cord-306904-8iteddug	293	8	,	,	,
cord-306904-8iteddug	293	9	N	n	CD
cord-306904-8iteddug	293	10	-	-	HYPH
cord-306904-8iteddug	293	11	terminal	terminal	JJ
cord-306904-8iteddug	293	12	core	core	NN
cord-306904-8iteddug	293	13	domain	domain	NN
cord-306904-8iteddug	293	14	that	that	WDT
cord-306904-8iteddug	293	15	includes	include	VBZ
cord-306904-8iteddug	293	16	the	the	DT
cord-306904-8iteddug	293	17	first	first	JJ
cord-306904-8iteddug	293	18	161	161	CD
cord-306904-8iteddug	293	19	residues	residue	NNS
cord-306904-8iteddug	293	20	of	of	IN
cord-306904-8iteddug	293	21	the	the	DT
cord-306904-8iteddug	293	22	protein	protein	NN
cord-306904-8iteddug	293	23	and	and	CC
cord-306904-8iteddug	293	24	a	a	DT
cord-306904-8iteddug	293	25	small	small	JJ
cord-306904-8iteddug	293	26	C	c	NN
cord-306904-8iteddug	293	27	-	-	HYPH
cord-306904-8iteddug	293	28	terminal	terminal	NN
cord-306904-8iteddug	293	29	region	region	NN
cord-306904-8iteddug	293	30	containing	contain	VBG
cord-306904-8iteddug	293	31	the	the	DT
cord-306904-8iteddug	293	32	18	18	CD
cord-306904-8iteddug	293	33	remaining	remain	VBG
cord-306904-8iteddug	293	34	amino	amino	NN
cord-306904-8iteddug	293	35	acids	acid	NNS
cord-306904-8iteddug	293	36	.	.	.
cord-306904-8iteddug	294	1	91	91	CD
cord-306904-8iteddug	294	2	Disorder	disorder	NN
cord-306904-8iteddug	294	3	analysis	analysis	NN
cord-306904-8iteddug	294	4	of	of	IN
cord-306904-8iteddug	294	5	this	this	DT
cord-306904-8iteddug	294	6	protein	protein	NN
cord-306904-8iteddug	294	7	(	(	-LRB-
cord-306904-8iteddug	294	8	UniProt	UniProt	NNP
cord-306904-8iteddug	294	9	ID	ID	NNP
cord-306904-8iteddug	294	10	:	:	:
cord-306904-8iteddug	294	11	P0A8J2	P0A8J2	NNP
cord-306904-8iteddug	294	12	)	)	-RRB-
cord-306904-8iteddug	294	13	revealed	reveal	VBD
cord-306904-8iteddug	294	14	that	that	IN
cord-306904-8iteddug	294	15	although	although	IN
cord-306904-8iteddug	294	16	the	the	DT
cord-306904-8iteddug	294	17	majority	majority	NN
cord-306904-8iteddug	294	18	of	of	IN
cord-306904-8iteddug	294	19	the	the	DT
cord-306904-8iteddug	294	20	DnaT	DnaT	NNP
cord-306904-8iteddug	294	21	is	be	VBZ
cord-306904-8iteddug	294	22	predicted	predict	VBN
cord-306904-8iteddug	294	23	to	to	TO
cord-306904-8iteddug	294	24	be	be	VB
cord-306904-8iteddug	294	25	ordered	order	VBN
cord-306904-8iteddug	294	26	,	,	,
cord-306904-8iteddug	294	27	the	the	DT
cord-306904-8iteddug	294	28	crucial	crucial	NN
cord-306904-8iteddug	294	29	for	for	IN
cord-306904-8iteddug	294	30	trimerization	trimerization	NN
cord-306904-8iteddug	294	31	Cterminal	cterminal	JJ
cord-306904-8iteddug	294	32	tail	tail	NN
cord-306904-8iteddug	294	33	is	be	VBZ
cord-306904-8iteddug	294	34	expected	expect	VBN
cord-306904-8iteddug	294	35	to	to	TO
cord-306904-8iteddug	294	36	be	be	VB
cord-306904-8iteddug	294	37	completely	completely	RB
cord-306904-8iteddug	294	38	disordered	disordered	JJ
cord-306904-8iteddug	294	39	(	(	-LRB-
cord-306904-8iteddug	294	40	see	see	VB
cord-306904-8iteddug	294	41	Fig	Fig	NNP
cord-306904-8iteddug	294	42	.	.	.
cord-306904-8iteddug	294	43	8D	8D	NNP
cord-306904-8iteddug	294	44	)	)	-RRB-
cord-306904-8iteddug	294	45	.	.	.
cord-306904-8iteddug	295	1	This	this	DT
cord-306904-8iteddug	295	2	observation	observation	NN
cord-306904-8iteddug	295	3	is	be	VBZ
cord-306904-8iteddug	295	4	in	in	IN
cord-306904-8iteddug	295	5	agreement	agreement	NN
cord-306904-8iteddug	295	6	with	with	IN
cord-306904-8iteddug	295	7	recent	recent	JJ
cord-306904-8iteddug	295	8	notion	notion	NN
cord-306904-8iteddug	295	9	that	that	IN
cord-306904-8iteddug	295	10	disordered	disordered	JJ
cord-306904-8iteddug	295	11	protein	protein	NN
cord-306904-8iteddug	295	12	tails	tail	NNS
cord-306904-8iteddug	295	13	are	be	VBP
cord-306904-8iteddug	295	14	commonly	commonly	RB
cord-306904-8iteddug	295	15	involved	involve	VBN
cord-306904-8iteddug	295	16	in	in	IN
cord-306904-8iteddug	295	17	a	a	DT
cord-306904-8iteddug	295	18	wide	wide	JJ
cord-306904-8iteddug	295	19	array	array	NN
cord-306904-8iteddug	295	20	of	of	IN
cord-306904-8iteddug	295	21	important	important	JJ
cord-306904-8iteddug	295	22	functions	function	NNS
cord-306904-8iteddug	295	23	.	.	.
cord-306904-8iteddug	296	1	95	95	CD
cord-306904-8iteddug	297	1	Platelet	platelet	NN
cord-306904-8iteddug	297	2	endothelial	endothelial	JJ
cord-306904-8iteddug	297	3	cell	cell	NN
cord-306904-8iteddug	297	4	adhesion	adhesion	NN
cord-306904-8iteddug	297	5	molecule	molecule	NN
cord-306904-8iteddug	297	6	1	1	CD
cord-306904-8iteddug	297	7	(	(	-LRB-
cord-306904-8iteddug	297	8	PECAM-1	PECAM-1	NNP
cord-306904-8iteddug	297	9	)	)	-RRB-
cord-306904-8iteddug	298	1	Tourdot	Tourdot	NNP
cord-306904-8iteddug	298	2	et	et	FW
cord-306904-8iteddug	298	3	al	al	NNP
cord-306904-8iteddug	298	4	.	.	.
cord-306904-8iteddug	299	1	dedicated	dedicated	JJ
cord-306904-8iteddug	299	2	their	-PRON-	PRP$
cord-306904-8iteddug	299	3	research	research	NN
cord-306904-8iteddug	299	4	to	to	IN
cord-306904-8iteddug	299	5	the	the	DT
cord-306904-8iteddug	299	6	analysis	analysis	NN
cord-306904-8iteddug	299	7	of	of	IN
cord-306904-8iteddug	299	8	the	the	DT
cord-306904-8iteddug	299	9	effect	effect	NN
cord-306904-8iteddug	299	10	of	of	IN
cord-306904-8iteddug	299	11	the	the	DT
cord-306904-8iteddug	299	12	sequential	sequential	JJ
cord-306904-8iteddug	299	13	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	299	14	of	of	IN
cord-306904-8iteddug	299	15	immunoreceptor	immunoreceptor	JJ
cord-306904-8iteddug	299	16	tyrosine	tyrosine	NN
cord-306904-8iteddug	299	17	-	-	HYPH
cord-306904-8iteddug	299	18	based	base	VBN
cord-306904-8iteddug	299	19	inhibitory	inhibitory	JJ
cord-306904-8iteddug	299	20	motifs	motif	NNS
cord-306904-8iteddug	299	21	(	(	-LRB-
cord-306904-8iteddug	299	22	ITIMs	ITIMs	NNP
cord-306904-8iteddug	299	23	)	)	-RRB-
cord-306904-8iteddug	299	24	on	on	IN
cord-306904-8iteddug	299	25	function	function	NN
cord-306904-8iteddug	299	26	of	of	IN
cord-306904-8iteddug	299	27	the	the	DT
cord-306904-8iteddug	299	28	platelet	platelet	NN
cord-306904-8iteddug	299	29	endothelial	endothelial	JJ
cord-306904-8iteddug	299	30	cell	cell	NN
cord-306904-8iteddug	299	31	adhesion	adhesion	NN
cord-306904-8iteddug	299	32	molecule-1	molecule-1	NNP
cord-306904-8iteddug	299	33	(	(	-LRB-
cord-306904-8iteddug	299	34	PECAM-1	PECAM-1	NNP
cord-306904-8iteddug	299	35	)	)	-RRB-
cord-306904-8iteddug	299	36	.	.	.
cord-306904-8iteddug	300	1	96	96	CD
cord-306904-8iteddug	300	2	PECAM-1	PECAM-1	NNP
cord-306904-8iteddug	300	3	is	be	VBZ
cord-306904-8iteddug	300	4	a	a	DT
cord-306904-8iteddug	300	5	dual	dual	JJ
cord-306904-8iteddug	300	6	ITIM	ITIM	NNP
cord-306904-8iteddug	300	7	-	-	HYPH
cord-306904-8iteddug	300	8	containing	contain	VBG
cord-306904-8iteddug	300	9	receptor	receptor	NN
cord-306904-8iteddug	300	10	of	of	IN
cord-306904-8iteddug	300	11	the	the	DT
cord-306904-8iteddug	300	12	Ig	Ig	NNP
cord-306904-8iteddug	300	13	superfamily	superfamily	NN
cord-306904-8iteddug	300	14	that	that	WDT
cord-306904-8iteddug	300	15	is	be	VBZ
cord-306904-8iteddug	300	16	capable	capable	JJ
cord-306904-8iteddug	300	17	of	of	IN
cord-306904-8iteddug	300	18	inhibiting	inhibit	VBG
cord-306904-8iteddug	300	19	immunoreceptor	immunoreceptor	JJ
cord-306904-8iteddug	300	20	tyrosine	tyrosine	NN
cord-306904-8iteddug	300	21	-	-	HYPH
cord-306904-8iteddug	300	22	based	base	VBN
cord-306904-8iteddug	300	23	activation	activation	NN
cord-306904-8iteddug	300	24	motif	motif	NN
cord-306904-8iteddug	300	25	(	(	-LRB-
cord-306904-8iteddug	300	26	ITAM)induced	itam)induce	VBN
cord-306904-8iteddug	300	27	activation	activation	NN
cord-306904-8iteddug	300	28	of	of	IN
cord-306904-8iteddug	300	29	B	b	NN
cord-306904-8iteddug	300	30	cells	cell	NNS
cord-306904-8iteddug	300	31	,	,	,
cord-306904-8iteddug	300	32	T	t	NN
cord-306904-8iteddug	300	33	cells	cell	NNS
cord-306904-8iteddug	300	34	,	,	,
cord-306904-8iteddug	300	35	and	and	CC
cord-306904-8iteddug	300	36	mast	mast	NN
cord-306904-8iteddug	300	37	cells	cell	NNS
cord-306904-8iteddug	300	38	,	,	,
cord-306904-8iteddug	300	39	as	as	RB
cord-306904-8iteddug	300	40	well	well	RB
cord-306904-8iteddug	300	41	as	as	IN
cord-306904-8iteddug	300	42	GPVI	GPVI	NNP
cord-306904-8iteddug	300	43	/	/	SYM
cord-306904-8iteddug	300	44	FcRg	FcRg	NNP
cord-306904-8iteddug	300	45	chainmediated	chainmediated	JJ
cord-306904-8iteddug	300	46	platelet	platelet	NN
cord-306904-8iteddug	300	47	activation	activation	NN
cord-306904-8iteddug	300	48	.	.	.
cord-306904-8iteddug	301	1	97	97	CD
cord-306904-8iteddug	302	1	The	the	DT
cord-306904-8iteddug	302	2	inhibitory	inhibitory	JJ
cord-306904-8iteddug	302	3	properties	property	NNS
cord-306904-8iteddug	302	4	of	of	IN
cord-306904-8iteddug	302	5	PECAM-1	PECAM-1	NNP
cord-306904-8iteddug	302	6	require	require	VBP
cord-306904-8iteddug	302	7	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	302	8	of	of	IN
cord-306904-8iteddug	302	9	both	both	DT
cord-306904-8iteddug	302	10	of	of	IN
cord-306904-8iteddug	302	11	its	-PRON-	PRP$
cord-306904-8iteddug	302	12	ITIMs	itim	NNS
cord-306904-8iteddug	302	13	located	locate	VBN
cord-306904-8iteddug	302	14	in	in	IN
cord-306904-8iteddug	302	15	the	the	DT
cord-306904-8iteddug	302	16	vicinity	vicinity	NN
cord-306904-8iteddug	302	17	of	of	IN
cord-306904-8iteddug	302	18	tyrosine	tyrosine	NN
cord-306904-8iteddug	302	19	residues	residue	NNS
cord-306904-8iteddug	302	20	at	at	IN
cord-306904-8iteddug	302	21	positions	position	NNS
cord-306904-8iteddug	302	22	663	663	CD
cord-306904-8iteddug	302	23	(	(	-LRB-
cord-306904-8iteddug	302	24	VQY	VQY	NNP
cord-306904-8iteddug	302	25	663	663	CD
cord-306904-8iteddug	302	26	TEV	TEV	NNP
cord-306904-8iteddug	302	27	)	)	-RRB-
cord-306904-8iteddug	302	28	and	and	CC
cord-306904-8iteddug	302	29	686	686	CD
cord-306904-8iteddug	303	1	(	(	-LRB-
cord-306904-8iteddug	303	2	TVY	TVY	NNP
cord-306904-8iteddug	303	3	686	686	CD
cord-306904-8iteddug	303	4	SEV	SEV	NNP
cord-306904-8iteddug	303	5	)	)	-RRB-
cord-306904-8iteddug	303	6	.	.	.
cord-306904-8iteddug	304	1	96	96	CD
cord-306904-8iteddug	305	1	Curiously	curiously	RB
cord-306904-8iteddug	305	2	,	,	,
cord-306904-8iteddug	305	3	the	the	DT
cord-306904-8iteddug	305	4	ITIMs	itim	NNS
cord-306904-8iteddug	305	5	of	of	IN
cord-306904-8iteddug	305	6	PECAM-1	PECAM-1	NNP
cord-306904-8iteddug	305	7	are	be	VBP
cord-306904-8iteddug	305	8	not	not	RB
cord-306904-8iteddug	305	9	phosphorylated	phosphorylate	VBN
cord-306904-8iteddug	305	10	in	in	IN
cord-306904-8iteddug	305	11	resting	rest	VBG
cord-306904-8iteddug	305	12	cells	cell	NNS
cord-306904-8iteddug	305	13	but	but	CC
cord-306904-8iteddug	305	14	are	be	VBP
cord-306904-8iteddug	305	15	phosphorylated	phosphorylate	VBN
cord-306904-8iteddug	305	16	upon	upon	IN
cord-306904-8iteddug	305	17	cellular	cellular	JJ
cord-306904-8iteddug	305	18	activation	activation	NN
cord-306904-8iteddug	305	19	.	.	.
cord-306904-8iteddug	306	1	Furthermore	furthermore	RB
cord-306904-8iteddug	306	2	,	,	,
cord-306904-8iteddug	306	3	these	these	DT
cord-306904-8iteddug	306	4	PECAM-1	pecam-1	JJ
cord-306904-8iteddug	306	5	ITIMs	itims	PRP
cord-306904-8iteddug	306	6	are	be	VBP
cord-306904-8iteddug	306	7	phosphorylated	phosphorylate	VBN
cord-306904-8iteddug	306	8	sequentially	sequentially	RB
cord-306904-8iteddug	306	9	,	,	,
cord-306904-8iteddug	306	10	with	with	IN
cord-306904-8iteddug	306	11	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	306	12	of	of	IN
cord-306904-8iteddug	306	13	Y	Y	NNP
cord-306904-8iteddug	306	14	663	663	CD
cord-306904-8iteddug	306	15	depending	depend	VBG
cord-306904-8iteddug	306	16	on	on	IN
cord-306904-8iteddug	306	17	prior	prior	JJ
cord-306904-8iteddug	306	18	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	306	19	of	of	IN
cord-306904-8iteddug	306	20	Y	Y	NNP
cord-306904-8iteddug	306	21	686	686	CD
cord-306904-8iteddug	306	22	.	.	.
cord-306904-8iteddug	307	1	98	98	CD
cord-306904-8iteddug	308	1	This	this	DT
cord-306904-8iteddug	308	2	sequential	sequential	JJ
cord-306904-8iteddug	308	3	process	process	NN
cord-306904-8iteddug	308	4	of	of	IN
cord-306904-8iteddug	308	5	the	the	DT
cord-306904-8iteddug	308	6	PECAM-1	pecam-1	JJ
cord-306904-8iteddug	308	7	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	308	8	starts	start	VBZ
cord-306904-8iteddug	308	9	with	with	IN
cord-306904-8iteddug	308	10	the	the	DT
cord-306904-8iteddug	308	11	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	308	12	of	of	IN
cord-306904-8iteddug	308	13	the	the	DT
cord-306904-8iteddug	308	14	C	C	NNP
cord-306904-8iteddug	308	15	-	-	HYPH
cord-306904-8iteddug	308	16	terminal	terminal	NN
cord-306904-8iteddug	308	17	ITIM	ITIM	NNP
cord-306904-8iteddug	308	18	by	by	IN
cord-306904-8iteddug	308	19	Src	Src	NNP
cord-306904-8iteddug	308	20	family	family	NN
cord-306904-8iteddug	308	21	kinases	kinase	NNS
cord-306904-8iteddug	308	22	,	,	,
cord-306904-8iteddug	308	23	which	which	WDT
cord-306904-8iteddug	308	24	enables	enable	VBZ
cord-306904-8iteddug	308	25	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	308	26	of	of	IN
cord-306904-8iteddug	308	27	the	the	DT
cord-306904-8iteddug	308	28	N	n	CD
cord-306904-8iteddug	308	29	-	-	HYPH
cord-306904-8iteddug	308	30	terminal	terminal	NN
cord-306904-8iteddug	308	31	ITIM	ITIM	NNP
cord-306904-8iteddug	308	32	of	of	IN
cord-306904-8iteddug	308	33	PECAM-1	PECAM-1	NNP
cord-306904-8iteddug	308	34	by	by	IN
cord-306904-8iteddug	308	35	other	other	JJ
cord-306904-8iteddug	308	36	Src	Src	NNP
cord-306904-8iteddug	308	37	homology	homology	NN
cord-306904-8iteddug	308	38	2	2	CD
cord-306904-8iteddug	308	39	domain	domain	NN
cord-306904-8iteddug	308	40	-	-	HYPH
cord-306904-8iteddug	308	41	containing	contain	VBG
cord-306904-8iteddug	308	42	nonreceptor	nonreceptor	NN
cord-306904-8iteddug	308	43	tyrosine	tyrosine	NN
cord-306904-8iteddug	308	44	kinases	kinase	NNS
cord-306904-8iteddug	308	45	(	(	-LRB-
cord-306904-8iteddug	308	46	NRTKs	NRTKs	NNP
cord-306904-8iteddug	308	47	)	)	-RRB-
cord-306904-8iteddug	308	48	.	.	.
cord-306904-8iteddug	309	1	96	96	CD
cord-306904-8iteddug	309	2	Figure	figure	NN
cord-306904-8iteddug	309	3	8E	8e	NN
cord-306904-8iteddug	309	4	shows	show	VBZ
cord-306904-8iteddug	309	5	that	that	IN
cord-306904-8iteddug	309	6	although	although	IN
cord-306904-8iteddug	309	7	human	human	JJ
cord-306904-8iteddug	309	8	PECAM-1	PECAM-1	NNP
cord-306904-8iteddug	309	9	(	(	-LRB-
cord-306904-8iteddug	309	10	UniProt	UniProt	NNP
cord-306904-8iteddug	309	11	ID	ID	NNP
cord-306904-8iteddug	309	12	:	:	:
cord-306904-8iteddug	309	13	P16284	P16284	NNP
cord-306904-8iteddug	309	14	)	)	-RRB-
cord-306904-8iteddug	309	15	is	be	VBZ
cord-306904-8iteddug	309	16	predicted	predict	VBN
cord-306904-8iteddug	309	17	to	to	TO
cord-306904-8iteddug	309	18	be	be	VB
cord-306904-8iteddug	309	19	mostly	mostly	RB
cord-306904-8iteddug	309	20	ordered	order	VBN
cord-306904-8iteddug	309	21	,	,	,
cord-306904-8iteddug	309	22	the	the	DT
cord-306904-8iteddug	309	23	residues	residue	NNS
cord-306904-8iteddug	309	24	,	,	,
cord-306904-8iteddug	309	25	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	309	26	of	of	IN
cord-306904-8iteddug	309	27	which	which	WDT
cord-306904-8iteddug	309	28	is	be	VBZ
cord-306904-8iteddug	309	29	crucial	crucial	JJ
cord-306904-8iteddug	309	30	for	for	IN
cord-306904-8iteddug	309	31	its	-PRON-	PRP$
cord-306904-8iteddug	309	32	function	function	NN
cord-306904-8iteddug	309	33	(	(	-LRB-
cord-306904-8iteddug	309	34	Y	Y	NNP
cord-306904-8iteddug	309	35	663	663	CD
cord-306904-8iteddug	309	36	and	and	CC
cord-306904-8iteddug	309	37	Y	Y	NNP
cord-306904-8iteddug	309	38	686	686	CD
cord-306904-8iteddug	309	39	)	)	-RRB-
cord-306904-8iteddug	309	40	,	,	,
cord-306904-8iteddug	309	41	are	be	VBP
cord-306904-8iteddug	309	42	located	locate	VBN
cord-306904-8iteddug	309	43	within	within	IN
cord-306904-8iteddug	309	44	the	the	DT
cord-306904-8iteddug	309	45	highly	highly	RB
cord-306904-8iteddug	309	46	disordered	disordered	JJ
cord-306904-8iteddug	309	47	C	c	NN
cord-306904-8iteddug	309	48	-	-	HYPH
cord-306904-8iteddug	309	49	terminal	terminal	NN
cord-306904-8iteddug	309	50	tail	tail	NN
cord-306904-8iteddug	309	51	.	.	.
cord-306904-8iteddug	310	1	Mouse	mouse	NN
cord-306904-8iteddug	310	2	serine	serine	NN
cord-306904-8iteddug	310	3	/	/	SYM
cord-306904-8iteddug	310	4	arginine	arginine	NN
cord-306904-8iteddug	310	5	-	-	HYPH
cord-306904-8iteddug	310	6	rich	rich	JJ
cord-306904-8iteddug	310	7	splicing	splicing	NN
cord-306904-8iteddug	310	8	factor	factor	NN
cord-306904-8iteddug	310	9	1	1	CD
cord-306904-8iteddug	311	1	(	(	-LRB-
cord-306904-8iteddug	311	2	SRSF1	SRSF1	NNP
cord-306904-8iteddug	311	3	)	)	-RRB-
cord-306904-8iteddug	312	1	Aubol	Aubol	NNP
cord-306904-8iteddug	312	2	et	et	NNP
cord-306904-8iteddug	312	3	al	al	NNP
cord-306904-8iteddug	312	4	.	.	NNP
cord-306904-8iteddug	312	5	studied	study	VBD
cord-306904-8iteddug	312	6	the	the	DT
cord-306904-8iteddug	312	7	molecular	molecular	JJ
cord-306904-8iteddug	312	8	mechanisms	mechanism	NNS
cord-306904-8iteddug	312	9	of	of	IN
cord-306904-8iteddug	312	10	the	the	DT
cord-306904-8iteddug	312	11	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	312	12	of	of	IN
cord-306904-8iteddug	312	13	SR	SR	NNP
cord-306904-8iteddug	312	14	splicing	splicing	NN
cord-306904-8iteddug	312	15	factors	factor	NNS
cord-306904-8iteddug	312	16	,	,	,
cord-306904-8iteddug	312	17	which	which	WDT
cord-306904-8iteddug	312	18	are	be	VBP
cord-306904-8iteddug	312	19	the	the	DT
cord-306904-8iteddug	312	20	proteins	protein	NNS
cord-306904-8iteddug	312	21	possessing	possess	VBG
cord-306904-8iteddug	312	22	regions	region	NNS
cord-306904-8iteddug	312	23	enriched	enrich	VBN
cord-306904-8iteddug	312	24	in	in	IN
cord-306904-8iteddug	312	25	Arg	Arg	NNP
cord-306904-8iteddug	312	26	-	-	HYPH
cord-306904-8iteddug	312	27	Ser	ser	JJ
cord-306904-8iteddug	312	28	dipeptide	dipeptide	NN
cord-306904-8iteddug	312	29	repeats	repeat	VBZ
cord-306904-8iteddug	312	30	known	know	VBN
cord-306904-8iteddug	312	31	as	as	IN
cord-306904-8iteddug	312	32	RS	rs	NN
cord-306904-8iteddug	312	33	domains	domain	NNS
cord-306904-8iteddug	312	34	,	,	,
cord-306904-8iteddug	312	35	by	by	IN
cord-306904-8iteddug	312	36	a	a	DT
cord-306904-8iteddug	312	37	specific	specific	JJ
cord-306904-8iteddug	312	38	serine	serine	NN
cord-306904-8iteddug	312	39	kinase	kinase	NN
cord-306904-8iteddug	312	40	SRPK1	SRPK1	NNP
cord-306904-8iteddug	312	41	.	.	.
cord-306904-8iteddug	313	1	99	99	CD
cord-306904-8iteddug	313	2	Phosphorylation	Phosphorylation	NNP
cord-306904-8iteddug	313	3	of	of	IN
cord-306904-8iteddug	313	4	RS	rs	NN
cord-306904-8iteddug	313	5	domains	domain	NNS
cord-306904-8iteddug	313	6	is	be	VBZ
cord-306904-8iteddug	313	7	crucial	crucial	JJ
cord-306904-8iteddug	313	8	for	for	IN
cord-306904-8iteddug	313	9	the	the	DT
cord-306904-8iteddug	313	10	regulation	regulation	NN
cord-306904-8iteddug	313	11	of	of	IN
cord-306904-8iteddug	313	12	the	the	DT
cord-306904-8iteddug	313	13	activities	activity	NNS
cord-306904-8iteddug	313	14	of	of	IN
cord-306904-8iteddug	313	15	the	the	DT
cord-306904-8iteddug	313	16	SR	SR	NNP
cord-306904-8iteddug	313	17	splicing	splicing	NN
cord-306904-8iteddug	313	18	factors	factor	NNS
cord-306904-8iteddug	313	19	.	.	.
cord-306904-8iteddug	314	1	RS	rs	NN
cord-306904-8iteddug	314	2	domains	domain	NNS
cord-306904-8iteddug	314	3	of	of	IN
cord-306904-8iteddug	314	4	SR	SR	NNP
cord-306904-8iteddug	314	5	proteins	protein	NNS
cord-306904-8iteddug	314	6	can	can	MD
cord-306904-8iteddug	314	7	range	range	VB
cord-306904-8iteddug	314	8	from	from	IN
cord-306904-8iteddug	314	9	50	50	CD
cord-306904-8iteddug	314	10	to	to	IN
cord-306904-8iteddug	314	11	over	over	IN
cord-306904-8iteddug	314	12	300	300	CD
cord-306904-8iteddug	314	13	residues	residue	NNS
cord-306904-8iteddug	314	14	in	in	IN
cord-306904-8iteddug	314	15	length	length	NN
cord-306904-8iteddug	314	16	,	,	,
cord-306904-8iteddug	314	17	and	and	CC
cord-306904-8iteddug	314	18	the	the	DT
cord-306904-8iteddug	314	19	Arg	Arg	NNP
cord-306904-8iteddug	314	20	-	-	HYPH
cord-306904-8iteddug	314	21	Ser	Ser	NNP
cord-306904-8iteddug	314	22	dipeptide	dipeptide	NN
cord-306904-8iteddug	314	23	repeats	repeat	NNS
cord-306904-8iteddug	314	24	can	can	MD
cord-306904-8iteddug	314	25	vary	vary	VB
cord-306904-8iteddug	314	26	in	in	IN
cord-306904-8iteddug	314	27	both	both	DT
cord-306904-8iteddug	314	28	length	length	NN
cord-306904-8iteddug	314	29	and	and	CC
cord-306904-8iteddug	314	30	position	position	NN
cord-306904-8iteddug	314	31	.	.	.
cord-306904-8iteddug	315	1	SRPK1	SRPK1	NNP
cord-306904-8iteddug	315	2	phosphorylates	phosphorylate	VBZ
cord-306904-8iteddug	315	3	the	the	DT
cord-306904-8iteddug	315	4	prototype	prototype	NN
cord-306904-8iteddug	315	5	SR	SR	NNP
cord-306904-8iteddug	315	6	protein	protein	NN
cord-306904-8iteddug	315	7	,	,	,
cord-306904-8iteddug	315	8	serine	serine	NN
cord-306904-8iteddug	315	9	/	/	SYM
cord-306904-8iteddug	315	10	arginine	arginine	NN
cord-306904-8iteddug	315	11	-	-	HYPH
cord-306904-8iteddug	315	12	rich	rich	JJ
cord-306904-8iteddug	315	13	splicing	splicing	NN
cord-306904-8iteddug	315	14	factor	factor	NN
cord-306904-8iteddug	315	15	1	1	CD
cord-306904-8iteddug	315	16	(	(	-LRB-
cord-306904-8iteddug	315	17	SRSF1	SRSF1	NNP
cord-306904-8iteddug	315	18	)	)	-RRB-
cord-306904-8iteddug	315	19	,	,	,
cord-306904-8iteddug	315	20	via	via	IN
cord-306904-8iteddug	315	21	a	a	DT
cord-306904-8iteddug	315	22	directional	directional	JJ
cord-306904-8iteddug	315	23	mechanism	mechanism	NN
cord-306904-8iteddug	315	24	where	where	WRB
cord-306904-8iteddug	315	25	11	11	CD
cord-306904-8iteddug	315	26	serines	serine	NNS
cord-306904-8iteddug	315	27	flanked	flank	VBN
cord-306904-8iteddug	315	28	by	by	IN
cord-306904-8iteddug	315	29	arginines	arginine	NNS
cord-306904-8iteddug	315	30	are	be	VBP
cord-306904-8iteddug	315	31	sequentially	sequentially	RB
cord-306904-8iteddug	315	32	fed	feed	VBN
cord-306904-8iteddug	315	33	from	from	IN
cord-306904-8iteddug	315	34	a	a	DT
cord-306904-8iteddug	315	35	docking	docking	NN
cord-306904-8iteddug	315	36	groove	groove	NN
cord-306904-8iteddug	315	37	in	in	IN
cord-306904-8iteddug	315	38	the	the	DT
cord-306904-8iteddug	315	39	large	large	JJ
cord-306904-8iteddug	315	40	lobe	lobe	NN
cord-306904-8iteddug	315	41	of	of	IN
cord-306904-8iteddug	315	42	the	the	DT
cord-306904-8iteddug	315	43	kinase	kinase	NN
cord-306904-8iteddug	315	44	domain	domain	NN
cord-306904-8iteddug	315	45	to	to	IN
cord-306904-8iteddug	315	46	the	the	DT
cord-306904-8iteddug	315	47	active	active	JJ
cord-306904-8iteddug	315	48	site	site	NN
cord-306904-8iteddug	315	49	.	.	.
cord-306904-8iteddug	316	1	99	99	CD
cord-306904-8iteddug	316	2	Figure	figure	NN
cord-306904-8iteddug	316	3	8F	8f	NN
cord-306904-8iteddug	316	4	shows	show	VBZ
cord-306904-8iteddug	316	5	that	that	IN
cord-306904-8iteddug	316	6	SRSF1	srsf1	XX
cord-306904-8iteddug	317	1	(	(	-LRB-
cord-306904-8iteddug	317	2	UniProt	UniProt	NNP
cord-306904-8iteddug	317	3	ID	ID	NNP
cord-306904-8iteddug	317	4	:	:	:
cord-306904-8iteddug	317	5	Q6PDM2	Q6PDM2	NNP
cord-306904-8iteddug	317	6	)	)	-RRB-
cord-306904-8iteddug	317	7	is	be	VBZ
cord-306904-8iteddug	317	8	predicted	predict	VBN
cord-306904-8iteddug	317	9	to	to	TO
cord-306904-8iteddug	317	10	be	be	VB
cord-306904-8iteddug	317	11	a	a	DT
cord-306904-8iteddug	317	12	highly	highly	RB
cord-306904-8iteddug	317	13	disordered	disordered	JJ
cord-306904-8iteddug	317	14	protein	protein	NN
cord-306904-8iteddug	317	15	.	.	.
cord-306904-8iteddug	318	1	The	the	DT
cord-306904-8iteddug	318	2	disordered	disordered	JJ
cord-306904-8iteddug	318	3	nature	nature	NN
cord-306904-8iteddug	318	4	of	of	IN
cord-306904-8iteddug	318	5	this	this	DT
cord-306904-8iteddug	318	6	splicing	splicing	NN
cord-306904-8iteddug	318	7	factor	factor	NN
cord-306904-8iteddug	318	8	is	be	VBZ
cord-306904-8iteddug	318	9	in	in	IN
cord-306904-8iteddug	318	10	agreement	agreement	NN
cord-306904-8iteddug	318	11	with	with	IN
cord-306904-8iteddug	318	12	recent	recent	JJ
cord-306904-8iteddug	318	13	bioinformatics	bioinformatic	NNS
cord-306904-8iteddug	318	14	studies	study	NNS
cord-306904-8iteddug	318	15	,	,	,
cord-306904-8iteddug	318	16	which	which	WDT
cord-306904-8iteddug	318	17	showed	show	VBD
cord-306904-8iteddug	318	18	that	that	IN
cord-306904-8iteddug	318	19	human	human	JJ
cord-306904-8iteddug	318	20	100	100	CD
cord-306904-8iteddug	318	21	and	and	CC
cord-306904-8iteddug	318	22	yeast	yeast	NN
cord-306904-8iteddug	318	23	spliceosomes	spliceosome	NNS
cord-306904-8iteddug	318	24	101	101	CD
cord-306904-8iteddug	318	25	are	be	VBP
cord-306904-8iteddug	318	26	enriched	enrich	VBN
cord-306904-8iteddug	318	27	in	in	IN
cord-306904-8iteddug	318	28	intrinsic	intrinsic	JJ
cord-306904-8iteddug	318	29	disorder	disorder	NN
cord-306904-8iteddug	318	30	,	,	,
cord-306904-8iteddug	318	31	and	and	CC
cord-306904-8iteddug	318	32	abundant	abundant	JJ
cord-306904-8iteddug	318	33	disordered	disordered	JJ
cord-306904-8iteddug	318	34	regions	region	NNS
cord-306904-8iteddug	318	35	are	be	VBP
cord-306904-8iteddug	318	36	crucial	crucial	JJ
cord-306904-8iteddug	318	37	for	for	IN
cord-306904-8iteddug	318	38	functions	function	NNS
cord-306904-8iteddug	318	39	of	of	IN
cord-306904-8iteddug	318	40	numerous	numerous	JJ
cord-306904-8iteddug	318	41	auxiliary	auxiliary	JJ
cord-306904-8iteddug	318	42	protein	protein	NN
cord-306904-8iteddug	318	43	factors	factor	NNS
cord-306904-8iteddug	318	44	involved	involve	VBN
cord-306904-8iteddug	318	45	in	in	IN
cord-306904-8iteddug	318	46	the	the	DT
cord-306904-8iteddug	318	47	formation	formation	NN
cord-306904-8iteddug	318	48	of	of	IN
cord-306904-8iteddug	318	49	this	this	DT
cord-306904-8iteddug	318	50	ribonucleoprotein	ribonucleoprotein	NN
cord-306904-8iteddug	318	51	complex	complex	NN
cord-306904-8iteddug	318	52	.	.	.
cord-306904-8iteddug	319	1	100	100	CD
cord-306904-8iteddug	319	2	,	,	,
cord-306904-8iteddug	319	3	101	101	CD
cord-306904-8iteddug	320	1	The	the	DT
cord-306904-8iteddug	320	2	potential	potential	JJ
cord-306904-8iteddug	320	3	functionality	functionality	NN
cord-306904-8iteddug	320	4	of	of	IN
cord-306904-8iteddug	320	5	the	the	DT
cord-306904-8iteddug	320	6	disordered	disordered	JJ
cord-306904-8iteddug	320	7	regions	region	NNS
cord-306904-8iteddug	320	8	found	find	VBN
cord-306904-8iteddug	320	9	in	in	IN
cord-306904-8iteddug	320	10	mouse	mouse	NN
cord-306904-8iteddug	320	11	SRSF1	SRSF1	NNS
cord-306904-8iteddug	320	12	was	be	VBD
cord-306904-8iteddug	320	13	further	further	RB
cord-306904-8iteddug	320	14	supported	support	VBN
cord-306904-8iteddug	320	15	by	by	IN
cord-306904-8iteddug	320	16	ANCHOR	anchor	NN
cord-306904-8iteddug	320	17	-	-	HYPH
cord-306904-8iteddug	320	18	based	base	VBN
cord-306904-8iteddug	320	19	analysis	analysis	NN
cord-306904-8iteddug	320	20	,	,	,
cord-306904-8iteddug	320	21	15	15	CD
cord-306904-8iteddug	320	22	102	102	CD
cord-306904-8iteddug	320	23	Replication	replication	NN
cord-306904-8iteddug	320	24	of	of	IN
cord-306904-8iteddug	320	25	viruses	virus	NNS
cord-306904-8iteddug	320	26	requires	require	VBZ
cord-306904-8iteddug	320	27	breaching	breach	VBG
cord-306904-8iteddug	320	28	the	the	DT
cord-306904-8iteddug	320	29	plasma	plasma	NN
cord-306904-8iteddug	320	30	membrane	membrane	NN
cord-306904-8iteddug	320	31	of	of	IN
cord-306904-8iteddug	320	32	the	the	DT
cord-306904-8iteddug	320	33	host	host	NN
cord-306904-8iteddug	320	34	cell	cell	NN
cord-306904-8iteddug	320	35	.	.	.
cord-306904-8iteddug	321	1	The	the	DT
cord-306904-8iteddug	321	2	entry	entry	NN
cord-306904-8iteddug	321	3	of	of	IN
cord-306904-8iteddug	321	4	the	the	DT
cord-306904-8iteddug	321	5	enveloped	envelop	VBN
cord-306904-8iteddug	321	6	viruses	virus	NNS
cord-306904-8iteddug	321	7	relies	rely	VBZ
cord-306904-8iteddug	321	8	on	on	IN
cord-306904-8iteddug	321	9	the	the	DT
cord-306904-8iteddug	321	10	specialized	specialized	JJ
cord-306904-8iteddug	321	11	fusion	fusion	NN
cord-306904-8iteddug	321	12	proteins	protein	NNS
cord-306904-8iteddug	321	13	.	.	.
cord-306904-8iteddug	322	1	There	there	EX
cord-306904-8iteddug	322	2	are	be	VBP
cord-306904-8iteddug	322	3	3	3	CD
cord-306904-8iteddug	322	4	major	major	JJ
cord-306904-8iteddug	322	5	classes	class	NNS
cord-306904-8iteddug	322	6	of	of	IN
cord-306904-8iteddug	322	7	viral	viral	JJ
cord-306904-8iteddug	322	8	fusion	fusion	NN
cord-306904-8iteddug	322	9	proteins	protein	NNS
cord-306904-8iteddug	322	10	,	,	,
cord-306904-8iteddug	322	11	all	all	DT
cord-306904-8iteddug	322	12	containing	contain	VBG
cord-306904-8iteddug	322	13	a	a	DT
cord-306904-8iteddug	322	14	fusion	fusion	NN
cord-306904-8iteddug	322	15	peptide	peptide	NN
cord-306904-8iteddug	322	16	that	that	IN
cord-306904-8iteddug	322	17	inserts	insert	VBZ
cord-306904-8iteddug	322	18	into	into	IN
cord-306904-8iteddug	322	19	the	the	DT
cord-306904-8iteddug	322	20	cytolemma	cytolemma	NNP
cord-306904-8iteddug	322	21	,	,	,
cord-306904-8iteddug	322	22	thereby	thereby	RB
cord-306904-8iteddug	322	23	anchoring	anchor	VBG
cord-306904-8iteddug	322	24	the	the	DT
cord-306904-8iteddug	322	25	2	2	CD
cord-306904-8iteddug	322	26	membranes	membrane	NNS
cord-306904-8iteddug	322	27	side	side	NN
cord-306904-8iteddug	322	28	by	by	IN
cord-306904-8iteddug	322	29	side	side	NN
cord-306904-8iteddug	322	30	.	.	.
cord-306904-8iteddug	323	1	106	106	CD
cord-306904-8iteddug	323	2	Human	Human	NNP
cord-306904-8iteddug	323	3	IFITMs	IFITMs	NNPS
cord-306904-8iteddug	323	4	block	block	VBP
cord-306904-8iteddug	323	5	the	the	DT
cord-306904-8iteddug	323	6	entry	entry	NN
cord-306904-8iteddug	323	7	of	of	IN
cord-306904-8iteddug	323	8	viruses	virus	NNS
cord-306904-8iteddug	323	9	from	from	IN
cord-306904-8iteddug	323	10	each	each	DT
cord-306904-8iteddug	323	11	of	of	IN
cord-306904-8iteddug	323	12	the	the	DT
cord-306904-8iteddug	323	13	3	3	CD
cord-306904-8iteddug	323	14	classes	class	NNS
cord-306904-8iteddug	323	15	of	of	IN
cord-306904-8iteddug	323	16	viral	viral	JJ
cord-306904-8iteddug	323	17	fusion	fusion	NN
cord-306904-8iteddug	323	18	proteins	protein	NNS
cord-306904-8iteddug	323	19	,	,	,
cord-306904-8iteddug	323	20	102	102	CD
cord-306904-8iteddug	323	21	by	by	IN
cord-306904-8iteddug	323	22	preventing	prevent	VBG
cord-306904-8iteddug	323	23	viral	viral	JJ
cord-306904-8iteddug	323	24	-	-	HYPH
cord-306904-8iteddug	323	25	host	host	NN
cord-306904-8iteddug	323	26	membrane	membrane	NN
cord-306904-8iteddug	323	27	fusion	fusion	NN
cord-306904-8iteddug	323	28	subsequent	subsequent	JJ
cord-306904-8iteddug	323	29	to	to	IN
cord-306904-8iteddug	323	30	viral	viral	JJ
cord-306904-8iteddug	323	31	binding	binding	NN
cord-306904-8iteddug	323	32	and	and	CC
cord-306904-8iteddug	323	33	endocytosis	endocytosis	NN
cord-306904-8iteddug	323	34	.	.	.
cord-306904-8iteddug	324	1	104	104	CD
cord-306904-8iteddug	324	2	,	,	,
cord-306904-8iteddug	324	3	107	107	CD
cord-306904-8iteddug	325	1	In	in	IN
cord-306904-8iteddug	325	2	humans	human	NNS
cord-306904-8iteddug	325	3	,	,	,
cord-306904-8iteddug	325	4	there	there	EX
cord-306904-8iteddug	325	5	are	be	VBP
cord-306904-8iteddug	325	6	5	5	CD
cord-306904-8iteddug	325	7	IFITMs	ifitms	NN
cord-306904-8iteddug	325	8	(	(	-LRB-
cord-306904-8iteddug	325	9	IFITM1	ifitm1	NN
cord-306904-8iteddug	325	10	,	,	,
cord-306904-8iteddug	325	11	2	2	CD
cord-306904-8iteddug	325	12	,	,	,
cord-306904-8iteddug	325	13	3	3	CD
cord-306904-8iteddug	325	14	,	,	,
cord-306904-8iteddug	325	15	5	5	CD
cord-306904-8iteddug	325	16	,	,	,
cord-306904-8iteddug	325	17	and	and	CC
cord-306904-8iteddug	325	18	10	10	CD
cord-306904-8iteddug	325	19	;	;	,
cord-306904-8iteddug	325	20	corresponding	correspond	VBG
cord-306904-8iteddug	325	21	UniProt	UniProt	NNP
cord-306904-8iteddug	325	22	IDs	id	NNS
cord-306904-8iteddug	325	23	:	:	:
cord-306904-8iteddug	325	24	P13164	P13164	NNP
cord-306904-8iteddug	325	25	,	,	,
cord-306904-8iteddug	325	26	Q01629	Q01629	NNP
cord-306904-8iteddug	325	27	,	,	,
cord-306904-8iteddug	325	28	Q01628	Q01628	NNP
cord-306904-8iteddug	325	29	,	,	,
cord-306904-8iteddug	325	30	A6NNB3	A6NNB3	NNP
cord-306904-8iteddug	325	31	,	,	,
cord-306904-8iteddug	325	32	and	and	CC
cord-306904-8iteddug	325	33	A6NMD0	A6NMD0	NNP
cord-306904-8iteddug	325	34	)	)	-RRB-
cord-306904-8iteddug	325	35	.	.	.
cord-306904-8iteddug	326	1	These	these	DT
cord-306904-8iteddug	326	2	proteins	protein	NNS
cord-306904-8iteddug	326	3	each	each	DT
cord-306904-8iteddug	326	4	contain	contain	VBP
cord-306904-8iteddug	326	5	2	2	CD
cord-306904-8iteddug	326	6	hydrophobic	hydrophobic	JJ
cord-306904-8iteddug	326	7	membrane	membrane	NN
cord-306904-8iteddug	326	8	-	-	HYPH
cord-306904-8iteddug	326	9	associated	associate	VBN
cord-306904-8iteddug	326	10	domains	domain	NNS
cord-306904-8iteddug	326	11	separated	separate	VBN
cord-306904-8iteddug	326	12	by	by	IN
cord-306904-8iteddug	326	13	a	a	DT
cord-306904-8iteddug	326	14	conserved	conserve	VBN
cord-306904-8iteddug	326	15	intracellular	intracellular	JJ
cord-306904-8iteddug	326	16	loop	loop	NN
cord-306904-8iteddug	326	17	.	.	.
cord-306904-8iteddug	327	1	All	all	DT
cord-306904-8iteddug	327	2	of	of	IN
cord-306904-8iteddug	327	3	them	-PRON-	PRP
cord-306904-8iteddug	327	4	also	also	RB
cord-306904-8iteddug	327	5	contain	contain	VBP
cord-306904-8iteddug	327	6	the	the	DT
cord-306904-8iteddug	327	7	cytosolically	cytosolically	RB
cord-306904-8iteddug	327	8	-	-	HYPH
cord-306904-8iteddug	327	9	located	locate	VBN
cord-306904-8iteddug	327	10	N	n	CD
cord-306904-8iteddug	327	11	-	-	HYPH
cord-306904-8iteddug	327	12	terminal	terminal	NN
cord-306904-8iteddug	327	13	domain	domain	NN
cord-306904-8iteddug	327	14	(	(	-LRB-
cord-306904-8iteddug	327	15	NTD	NTD	NNP
cord-306904-8iteddug	327	16	)	)	-RRB-
cord-306904-8iteddug	327	17	of	of	IN
cord-306904-8iteddug	327	18	various	various	JJ
cord-306904-8iteddug	327	19	length	length	NN
cord-306904-8iteddug	327	20	.	.	.
cord-306904-8iteddug	328	1	102	102	CD
cord-306904-8iteddug	328	2	Figure	figure	NN
cord-306904-8iteddug	328	3	9	9	CD
cord-306904-8iteddug	328	4	shows	show	NNS
cord-306904-8iteddug	328	5	that	that	IN
cord-306904-8iteddug	328	6	the	the	DT
cord-306904-8iteddug	328	7	NTDs	ntd	NNS
cord-306904-8iteddug	328	8	of	of	IN
cord-306904-8iteddug	328	9	all	all	DT
cord-306904-8iteddug	328	10	5	5	CD
cord-306904-8iteddug	328	11	human	human	NN
cord-306904-8iteddug	328	12	IFITMs	ifitm	NNS
cord-306904-8iteddug	328	13	are	be	VBP
cord-306904-8iteddug	328	14	predicted	predict	VBN
cord-306904-8iteddug	328	15	to	to	TO
cord-306904-8iteddug	328	16	be	be	VB
cord-306904-8iteddug	328	17	intrinsically	intrinsically	RB
cord-306904-8iteddug	328	18	disordered	disordered	JJ
cord-306904-8iteddug	328	19	.	.	.
cord-306904-8iteddug	329	1	The	the	DT
cord-306904-8iteddug	329	2	likely	likely	JJ
cord-306904-8iteddug	329	3	functional	functional	JJ
cord-306904-8iteddug	329	4	role	role	NN
cord-306904-8iteddug	329	5	of	of	IN
cord-306904-8iteddug	329	6	these	these	DT
cord-306904-8iteddug	329	7	disordered	disordered	JJ
cord-306904-8iteddug	329	8	tails	tail	NNS
cord-306904-8iteddug	329	9	is	be	VBZ
cord-306904-8iteddug	329	10	reflected	reflect	VBN
cord-306904-8iteddug	329	11	in	in	IN
cord-306904-8iteddug	329	12	the	the	DT
cord-306904-8iteddug	329	13	fact	fact	NN
cord-306904-8iteddug	329	14	that	that	IN
cord-306904-8iteddug	329	15	the	the	DT
cord-306904-8iteddug	329	16	longest	long	JJS
cord-306904-8iteddug	329	17	NTD	NTD	NNP
cord-306904-8iteddug	329	18	of	of	IN
cord-306904-8iteddug	329	19	IFITM10	IFITM10	NNP
cord-306904-8iteddug	329	20	contains	contain	VBZ
cord-306904-8iteddug	329	21	3	3	CD
cord-306904-8iteddug	329	22	AiBSs	AiBSs	NNP
cord-306904-8iteddug	329	23	,	,	,
cord-306904-8iteddug	329	24	residues	residue	NNS
cord-306904-8iteddug	329	25	8	8	CD
cord-306904-8iteddug	329	26	-	-	SYM
cord-306904-8iteddug	329	27	29	29	CD
cord-306904-8iteddug	329	28	,	,	,
cord-306904-8iteddug	329	29	51	51	CD
cord-306904-8iteddug	329	30	-	-	SYM
cord-306904-8iteddug	329	31	64	64	CD
cord-306904-8iteddug	329	32	,	,	,
cord-306904-8iteddug	329	33	and	and	CC
cord-306904-8iteddug	329	34	71	71	CD
cord-306904-8iteddug	329	35	-	-	SYM
cord-306904-8iteddug	329	36	82	82	CD
cord-306904-8iteddug	329	37	.	.	.
cord-306904-8iteddug	330	1	Shorter	short	JJR
cord-306904-8iteddug	330	2	tails	tail	NNS
cord-306904-8iteddug	330	3	of	of	IN
cord-306904-8iteddug	330	4	other	other	JJ
cord-306904-8iteddug	330	5	human	human	NN
cord-306904-8iteddug	330	6	IFITMs	ifitm	NNS
cord-306904-8iteddug	330	7	might	may	MD
cord-306904-8iteddug	330	8	also	also	RB
cord-306904-8iteddug	330	9	be	be	VB
cord-306904-8iteddug	330	10	involved	involve	VBN
cord-306904-8iteddug	330	11	in	in	IN
cord-306904-8iteddug	330	12	protein	protein	NN
cord-306904-8iteddug	330	13	-	-	HYPH
cord-306904-8iteddug	330	14	protein	protein	NN
cord-306904-8iteddug	330	15	interactions	interaction	NNS
cord-306904-8iteddug	330	16	since	since	IN
cord-306904-8iteddug	330	17	all	all	DT
cord-306904-8iteddug	330	18	of	of	IN
cord-306904-8iteddug	330	19	them	-PRON-	PRP
cord-306904-8iteddug	330	20	contain	contain	VBP
cord-306904-8iteddug	330	21	characteristic	characteristic	JJ
cord-306904-8iteddug	330	22	"	"	''
cord-306904-8iteddug	330	23	dips	dip	NNS
cord-306904-8iteddug	330	24	,	,	,
cord-306904-8iteddug	330	25	"	"	''
cord-306904-8iteddug	330	26	which	which	WDT
cord-306904-8iteddug	330	27	are	be	VBP
cord-306904-8iteddug	330	28	commonly	commonly	RB
cord-306904-8iteddug	330	29	associated	associate	VBN
cord-306904-8iteddug	330	30	with	with	IN
cord-306904-8iteddug	330	31	the	the	DT
cord-306904-8iteddug	330	32	existence	existence	NN
cord-306904-8iteddug	330	33	of	of	IN
cord-306904-8iteddug	330	34	specific	specific	JJ
cord-306904-8iteddug	330	35	molecular	molecular	JJ
cord-306904-8iteddug	330	36	recognition	recognition	NN
cord-306904-8iteddug	330	37	features	feature	NNS
cord-306904-8iteddug	330	38	,	,	,
cord-306904-8iteddug	330	39	MoRFs	MoRFs	NNP
cord-306904-8iteddug	330	40	,	,	,
cord-306904-8iteddug	330	41	which	which	WDT
cord-306904-8iteddug	330	42	are	be	VBP
cord-306904-8iteddug	330	43	short	short	JJ
cord-306904-8iteddug	330	44	foldingprone	foldingprone	NN
cord-306904-8iteddug	330	45	fragments	fragment	NNS
cord-306904-8iteddug	330	46	of	of	IN
cord-306904-8iteddug	330	47	disordered	disordered	JJ
cord-306904-8iteddug	330	48	regions	region	NNS
cord-306904-8iteddug	330	49	that	that	WDT
cord-306904-8iteddug	330	50	are	be	VBP
cord-306904-8iteddug	330	51	able	able	JJ
cord-306904-8iteddug	330	52	to	to	TO
cord-306904-8iteddug	330	53	fold	fold	VB
cord-306904-8iteddug	330	54	(	(	-LRB-
cord-306904-8iteddug	330	55	at	at	IN
cord-306904-8iteddug	330	56	least	least	JJS
cord-306904-8iteddug	330	57	partially	partially	RB
cord-306904-8iteddug	330	58	)	)	-RRB-
cord-306904-8iteddug	330	59	at	at	IN
cord-306904-8iteddug	330	60	interaction	interaction	NN
cord-306904-8iteddug	330	61	with	with	IN
cord-306904-8iteddug	330	62	specific	specific	JJ
cord-306904-8iteddug	330	63	binding	bind	VBG
cord-306904-8iteddug	330	64	partners	partner	NNS
cord-306904-8iteddug	330	65	.	.	.
cord-306904-8iteddug	331	1	[	[	-LRB-
cord-306904-8iteddug	331	2	108	108	CD
cord-306904-8iteddug	331	3	]	]	-RRB-
cord-306904-8iteddug	331	4	[	[	-LRB-
cord-306904-8iteddug	331	5	109	109	CD
cord-306904-8iteddug	331	6	]	]	-RRB-
cord-306904-8iteddug	331	7	[	[	-LRB-
cord-306904-8iteddug	331	8	110	110	CD
cord-306904-8iteddug	331	9	]	]	-RRB-
cord-306904-8iteddug	331	10	[	[	-LRB-
cord-306904-8iteddug	331	11	111	111	CD
cord-306904-8iteddug	331	12	]	]	-RRB-
cord-306904-8iteddug	331	13	[	[	-LRB-
cord-306904-8iteddug	331	14	112	112	CD
cord-306904-8iteddug	331	15	]	]	-RRB-
cord-306904-8iteddug	331	16	Chameleon	Chameleon	NNP
cord-306904-8iteddug	331	17	region	region	NN
cord-306904-8iteddug	331	18	undergoing	undergo	VBG
cord-306904-8iteddug	331	19	a	a	DT
cord-306904-8iteddug	331	20	-	-	HYPH
cord-306904-8iteddug	331	21	helix	helix	NN
cord-306904-8iteddug	331	22	to	to	IN
cord-306904-8iteddug	331	23	b	b	NN
cord-306904-8iteddug	331	24	-	-	HYPH
cord-306904-8iteddug	331	25	strand	strand	NN
cord-306904-8iteddug	331	26	transition	transition	NN
cord-306904-8iteddug	331	27	in	in	IN
cord-306904-8iteddug	331	28	the	the	DT
cord-306904-8iteddug	331	29	mutant	mutant	JJ
cord-306904-8iteddug	331	30	form	form	NN
cord-306904-8iteddug	331	31	of	of	IN
cord-306904-8iteddug	331	32	the	the	DT
cord-306904-8iteddug	331	33	type	type	NN
cord-306904-8iteddug	331	34	2	2	CD
cord-306904-8iteddug	331	35	ryanodine	ryanodine	JJ
cord-306904-8iteddug	331	36	receptor	receptor	NN
cord-306904-8iteddug	331	37	domain	domain	NN
cord-306904-8iteddug	331	38	A	a	NN
cord-306904-8iteddug	331	39	(	(	-LRB-
cord-306904-8iteddug	331	40	RyR2A	ryr2a	NN
cord-306904-8iteddug	331	41	)	)	-RRB-
cord-306904-8iteddug	331	42	linked	link	VBN
cord-306904-8iteddug	331	43	with	with	IN
cord-306904-8iteddug	331	44	a	a	DT
cord-306904-8iteddug	331	45	heritable	heritable	JJ
cord-306904-8iteddug	331	46	cardiomyopathy	cardiomyopathy	NN
cord-306904-8iteddug	331	47	Using	use	VBG
cord-306904-8iteddug	331	48	the	the	DT
cord-306904-8iteddug	331	49	solution	solution	NN
cord-306904-8iteddug	331	50	NMR	NMR	NNP
cord-306904-8iteddug	331	51	spectroscopy	spectroscopy	NN
cord-306904-8iteddug	331	52	and	and	CC
cord-306904-8iteddug	331	53	X	x	NN
cord-306904-8iteddug	331	54	-	-	NN
cord-306904-8iteddug	331	55	ray	ray	NN
cord-306904-8iteddug	331	56	crystallography	crystallography	NN
cord-306904-8iteddug	331	57	,	,	,
cord-306904-8iteddug	331	58	Amador	Amador	NNP
cord-306904-8iteddug	331	59	et	et	NNP
cord-306904-8iteddug	331	60	al	al	NNP
cord-306904-8iteddug	331	61	.	.	NNP
cord-306904-8iteddug	331	62	studied	study	VBD
cord-306904-8iteddug	331	63	the	the	DT
cord-306904-8iteddug	331	64	effects	effect	NNS
cord-306904-8iteddug	331	65	of	of	IN
cord-306904-8iteddug	331	66	mutations	mutation	NNS
cord-306904-8iteddug	331	67	associated	associate	VBN
cord-306904-8iteddug	331	68	with	with	IN
cord-306904-8iteddug	331	69	arrhythmogenic	arrhythmogenic	NNP
cord-306904-8iteddug	331	70	right	right	JJ
cord-306904-8iteddug	331	71	ventricular	ventricular	JJ
cord-306904-8iteddug	331	72	dysplasia	dysplasia	NN
cord-306904-8iteddug	331	73	type	type	NN
cord-306904-8iteddug	331	74	2	2	CD
cord-306904-8iteddug	331	75	(	(	-LRB-
cord-306904-8iteddug	331	76	ARVD2	ARVD2	NNP
cord-306904-8iteddug	331	77	)	)	-RRB-
cord-306904-8iteddug	331	78	on	on	IN
cord-306904-8iteddug	331	79	the	the	DT
cord-306904-8iteddug	331	80	structure	structure	NN
cord-306904-8iteddug	331	81	and	and	CC
cord-306904-8iteddug	331	82	dynamics	dynamic	NNS
cord-306904-8iteddug	331	83	of	of	IN
cord-306904-8iteddug	331	84	the	the	DT
cord-306904-8iteddug	331	85	N	n	CD
cord-306904-8iteddug	331	86	-	-	HYPH
cord-306904-8iteddug	331	87	terminal	terminal	NN
cord-306904-8iteddug	331	88	domain	domain	NN
cord-306904-8iteddug	331	89	of	of	IN
cord-306904-8iteddug	331	90	the	the	DT
cord-306904-8iteddug	331	91	mouse	mouse	NN
cord-306904-8iteddug	331	92	ryanodine	ryanodine	JJ
cord-306904-8iteddug	331	93	receptor	receptor	NN
cord-306904-8iteddug	331	94	RyR2A	ryr2a	NN
cord-306904-8iteddug	331	95	(	(	-LRB-
cord-306904-8iteddug	331	96	UniProt	UniProt	NNP
cord-306904-8iteddug	331	97	ID	ID	NNP
cord-306904-8iteddug	331	98	:	:	:
cord-306904-8iteddug	331	99	E9Q401	E9Q401	NNP
cord-306904-8iteddug	331	100	)	)	-RRB-
cord-306904-8iteddug	331	101	.	.	.
cord-306904-8iteddug	332	1	113	113	CD
cord-306904-8iteddug	332	2	Ryanodine	ryanodine	JJ
cord-306904-8iteddug	332	3	receptors	receptor	NNS
cord-306904-8iteddug	332	4	(	(	-LRB-
cord-306904-8iteddug	332	5	RyRs	RyRs	NNP
cord-306904-8iteddug	332	6	)	)	-RRB-
cord-306904-8iteddug	332	7	are	be	VBP
cord-306904-8iteddug	332	8	the	the	DT
cord-306904-8iteddug	332	9	largest	large	JJS
cord-306904-8iteddug	332	10	tetrameric	tetrameric	JJ
cord-306904-8iteddug	332	11	Ca	Ca	NNP
cord-306904-8iteddug	332	12	2C	2c	NN
cord-306904-8iteddug	332	13	release	release	NN
cord-306904-8iteddug	332	14	channels	channel	NNS
cord-306904-8iteddug	332	15	(	(	-LRB-
cord-306904-8iteddug	332	16	»	»	``
cord-306904-8iteddug	332	17	2.2	2.2	CD
cord-306904-8iteddug	332	18	MDa	MDa	NNS
cord-306904-8iteddug	332	19	)	)	-RRB-
cord-306904-8iteddug	332	20	of	of	IN
cord-306904-8iteddug	332	21	the	the	DT
cord-306904-8iteddug	332	22	sarcoplasmic	sarcoplasmic	JJ
cord-306904-8iteddug	332	23	reticulum	reticulum	NN
cord-306904-8iteddug	332	24	in	in	IN
cord-306904-8iteddug	332	25	the	the	DT
cord-306904-8iteddug	332	26	electrically	electrically	RB
cord-306904-8iteddug	332	27	excitable	excitable	JJ
cord-306904-8iteddug	332	28	cells	cell	NNS
cord-306904-8iteddug	332	29	.	.	.
cord-306904-8iteddug	333	1	Here	here	RB
cord-306904-8iteddug	333	2	,	,	,
cord-306904-8iteddug	333	3	RyRs	RyRs	NNP
cord-306904-8iteddug	333	4	resides	reside	VBZ
cord-306904-8iteddug	333	5	in	in	IN
cord-306904-8iteddug	333	6	close	close	JJ
cord-306904-8iteddug	333	7	proximity	proximity	NN
cord-306904-8iteddug	333	8	to	to	IN
cord-306904-8iteddug	333	9	plasma	plasma	NN
cord-306904-8iteddug	333	10	membrane	membrane	NN
cord-306904-8iteddug	333	11	voltagegated	voltagegate	VBD
cord-306904-8iteddug	333	12	dihydropyridine	dihydropyridine	NNP
cord-306904-8iteddug	333	13	receptors	receptor	NNS
cord-306904-8iteddug	333	14	(	(	-LRB-
cord-306904-8iteddug	333	15	DHPRs	DHPRs	NNP
cord-306904-8iteddug	333	16	)	)	-RRB-
cord-306904-8iteddug	333	17	and	and	CC
cord-306904-8iteddug	333	18	respond	respond	VB
cord-306904-8iteddug	333	19	to	to	IN
cord-306904-8iteddug	333	20	the	the	DT
cord-306904-8iteddug	333	21	DHPR	DHPR	NNP
cord-306904-8iteddug	333	22	activity	activity	NN
cord-306904-8iteddug	333	23	through	through	IN
cord-306904-8iteddug	333	24	a	a	DT
cord-306904-8iteddug	333	25	direct	direct	JJ
cord-306904-8iteddug	333	26	interaction	interaction	NN
cord-306904-8iteddug	334	1	and/or	and/or	CC
cord-306904-8iteddug	334	2	indirect	indirect	JJ
cord-306904-8iteddug	335	1	Ca	ca	RB
cord-306904-8iteddug	335	2	2C	2c	NN
cord-306904-8iteddug	335	3	sensitivity	sensitivity	NN
cord-306904-8iteddug	335	4	,	,	,
cord-306904-8iteddug	335	5	propagating	propagate	VBG
cord-306904-8iteddug	335	6	sarcoplasmic	sarcoplasmic	JJ
cord-306904-8iteddug	335	7	reticulum	reticulum	NN
cord-306904-8iteddug	335	8	luminal	luminal	JJ
cord-306904-8iteddug	335	9	Ca	Ca	NNP
cord-306904-8iteddug	335	10	2C	2c	NN
cord-306904-8iteddug	335	11	release	release	NN
cord-306904-8iteddug	335	12	,	,	,
cord-306904-8iteddug	335	13	thereby	thereby	RB
cord-306904-8iteddug	335	14	playing	play	VBG
cord-306904-8iteddug	335	15	an	an	DT
cord-306904-8iteddug	335	16	integral	integral	JJ
cord-306904-8iteddug	335	17	role	role	NN
cord-306904-8iteddug	335	18	in	in	IN
cord-306904-8iteddug	335	19	excitation	excitation	NN
cord-306904-8iteddug	335	20	-	-	HYPH
cord-306904-8iteddug	335	21	contraction	contraction	NN
cord-306904-8iteddug	335	22	coupling	coupling	NN
cord-306904-8iteddug	335	23	in	in	IN
cord-306904-8iteddug	335	24	skeletal	skeletal	JJ
cord-306904-8iteddug	335	25	muscle	muscle	NN
cord-306904-8iteddug	335	26	cells	cell	NNS
cord-306904-8iteddug	335	27	and	and	CC
cord-306904-8iteddug	335	28	cardiomyocytes	cardiomyocyte	NNS
cord-306904-8iteddug	335	29	.	.	.
cord-306904-8iteddug	336	1	114	114	CD
cord-306904-8iteddug	336	2	,	,	,
cord-306904-8iteddug	336	3	115	115	CD
cord-306904-8iteddug	336	4	Mutations	Mutations	NNPS
cord-306904-8iteddug	336	5	in	in	IN
cord-306904-8iteddug	336	6	the	the	DT
cord-306904-8iteddug	336	7	RyR	RyR	NNS
cord-306904-8iteddug	336	8	genes	gene	NNS
cord-306904-8iteddug	336	9	are	be	VBP
cord-306904-8iteddug	336	10	associated	associate	VBN
cord-306904-8iteddug	336	11	with	with	IN
cord-306904-8iteddug	336	12	several	several	JJ
cord-306904-8iteddug	336	13	heritable	heritable	JJ
cord-306904-8iteddug	336	14	human	human	JJ
cord-306904-8iteddug	336	15	diseases	disease	NNS
cord-306904-8iteddug	336	16	,	,	,
cord-306904-8iteddug	336	17	with	with	IN
cord-306904-8iteddug	336	18	most	most	JJS
cord-306904-8iteddug	336	19	disease	disease	NN
cord-306904-8iteddug	336	20	-	-	HYPH
cord-306904-8iteddug	336	21	associated	associate	VBN
cord-306904-8iteddug	336	22	mutations	mutation	NNS
cord-306904-8iteddug	336	23	making	make	VBG
cord-306904-8iteddug	336	24	RyRs	ryr	NNS
cord-306904-8iteddug	336	25	hypersensitive	hypersensitive	JJ
cord-306904-8iteddug	336	26	to	to	IN
cord-306904-8iteddug	336	27	activating	activate	VBG
cord-306904-8iteddug	336	28	stimuli	stimulus	NNS
cord-306904-8iteddug	336	29	such	such	JJ
cord-306904-8iteddug	336	30	as	as	IN
cord-306904-8iteddug	336	31	Ca	Ca	NNP
cord-306904-8iteddug	336	32	2C	2c	NN
cord-306904-8iteddug	336	33	on	on	IN
cord-306904-8iteddug	336	34	either	either	CC
cord-306904-8iteddug	336	35	the	the	DT
cord-306904-8iteddug	336	36	luminal	luminal	JJ
cord-306904-8iteddug	336	37	or	or	CC
cord-306904-8iteddug	336	38	the	the	DT
cord-306904-8iteddug	336	39	cytosolic	cytosolic	JJ
cord-306904-8iteddug	336	40	side	side	NN
cord-306904-8iteddug	336	41	of	of	IN
cord-306904-8iteddug	336	42	the	the	DT
cord-306904-8iteddug	336	43	receptor	receptor	NN
cord-306904-8iteddug	336	44	.	.	.
cord-306904-8iteddug	337	1	In	in	IN
cord-306904-8iteddug	337	2	one	one	CD
cord-306904-8iteddug	337	3	of	of	IN
cord-306904-8iteddug	337	4	such	such	JJ
cord-306904-8iteddug	337	5	mutations	mutation	NNS
cord-306904-8iteddug	337	6	,	,	,
cord-306904-8iteddug	337	7	the	the	DT
cord-306904-8iteddug	337	8	removal	removal	NN
cord-306904-8iteddug	337	9	of	of	IN
cord-306904-8iteddug	337	10	exon	exon	NN
cord-306904-8iteddug	337	11	3	3	CD
cord-306904-8iteddug	337	12	in	in	IN
cord-306904-8iteddug	337	13	RyR2	RyR2	NNP
cord-306904-8iteddug	338	1	(	(	-LRB-
cord-306904-8iteddug	338	2	RyR2AD3	ryr2ad3	CD
cord-306904-8iteddug	338	3	)	)	-RRB-
cord-306904-8iteddug	338	4	results	result	VBZ
cord-306904-8iteddug	338	5	in	in	IN
cord-306904-8iteddug	338	6	a	a	DT
cord-306904-8iteddug	338	7	35-residue	35-residue	CD
cord-306904-8iteddug	338	8	deletion	deletion	NN
cord-306904-8iteddug	338	9	(	(	-LRB-
cord-306904-8iteddug	338	10	N57-G91	N57-G91	NNP
cord-306904-8iteddug	338	11	)	)	-RRB-
cord-306904-8iteddug	338	12	that	that	WDT
cord-306904-8iteddug	338	13	does	do	VBZ
cord-306904-8iteddug	338	14	not	not	RB
cord-306904-8iteddug	338	15	destabilize	destabilize	VB
cord-306904-8iteddug	338	16	the	the	DT
cord-306904-8iteddug	338	17	protein	protein	NN
cord-306904-8iteddug	338	18	.	.	.
cord-306904-8iteddug	339	1	116	116	CD
cord-306904-8iteddug	339	2	,	,	,
cord-306904-8iteddug	340	1	117	117	CD
cord-306904-8iteddug	340	2	Earlier	early	JJR
cord-306904-8iteddug	340	3	structural	structural	JJ
cord-306904-8iteddug	340	4	analysis	analysis	NN
cord-306904-8iteddug	340	5	revealed	reveal	VBD
cord-306904-8iteddug	340	6	that	that	IN
cord-306904-8iteddug	340	7	the	the	DT
cord-306904-8iteddug	340	8	b	b	NN
cord-306904-8iteddug	340	9	-	-	HYPH
cord-306904-8iteddug	340	10	trefoil	trefoil	NN
cord-306904-8iteddug	340	11	fold	fold	NN
cord-306904-8iteddug	340	12	of	of	IN
cord-306904-8iteddug	340	13	this	this	DT
cord-306904-8iteddug	340	14	domain	domain	NN
cord-306904-8iteddug	340	15	is	be	VBZ
cord-306904-8iteddug	340	16	rescued	rescue	VBN
cord-306904-8iteddug	340	17	by	by	IN
cord-306904-8iteddug	340	18	the	the	DT
cord-306904-8iteddug	340	19	transformation	transformation	NN
cord-306904-8iteddug	340	20	of	of	IN
cord-306904-8iteddug	340	21	the	the	DT
cord-306904-8iteddug	340	22	part	part	NN
cord-306904-8iteddug	340	23	of	of	IN
cord-306904-8iteddug	340	24	the	the	DT
cord-306904-8iteddug	340	25	preceding	precede	VBG
cord-306904-8iteddug	340	26	region	region	NN
cord-306904-8iteddug	340	27	of	of	IN
cord-306904-8iteddug	340	28	unknown	unknown	JJ
cord-306904-8iteddug	340	29	structure	structure	NN
cord-306904-8iteddug	340	30	(	(	-LRB-
cord-306904-8iteddug	340	31	residues	residue	NNS
cord-306904-8iteddug	340	32	88	88	CD
cord-306904-8iteddug	340	33	-	-	SYM
cord-306904-8iteddug	340	34	109	109	CD
cord-306904-8iteddug	340	35	)	)	-RRB-
cord-306904-8iteddug	340	36	into	into	IN
cord-306904-8iteddug	340	37	the	the	DT
cord-306904-8iteddug	340	38	missing	miss	VBG
cord-306904-8iteddug	340	39	b	b	NN
cord-306904-8iteddug	340	40	-	-	HYPH
cord-306904-8iteddug	340	41	strand	strand	NN
cord-306904-8iteddug	340	42	leading	lead	VBG
cord-306904-8iteddug	340	43	to	to	IN
cord-306904-8iteddug	340	44	the	the	DT
cord-306904-8iteddug	340	45	noticeable	noticeable	JJ
cord-306904-8iteddug	340	46	increase	increase	NN
cord-306904-8iteddug	340	47	in	in	IN
cord-306904-8iteddug	340	48	the	the	DT
cord-306904-8iteddug	340	49	thermal	thermal	JJ
cord-306904-8iteddug	340	50	stability	stability	NN
cord-306904-8iteddug	340	51	of	of	IN
cord-306904-8iteddug	340	52	the	the	DT
cord-306904-8iteddug	340	53	RyR2AD3	ryr2ad3	CD
cord-306904-8iteddug	340	54	domain	domain	NN
cord-306904-8iteddug	340	55	.	.	.
cord-306904-8iteddug	341	1	117	117	CD
cord-306904-8iteddug	342	1	Using	use	VBG
cord-306904-8iteddug	342	2	solution	solution	NN
cord-306904-8iteddug	342	3	NMR	NMR	NNP
cord-306904-8iteddug	342	4	analysis	analysis	NN
cord-306904-8iteddug	342	5	,	,	,
cord-306904-8iteddug	342	6	Amador	Amador	NNP
cord-306904-8iteddug	342	7	et	et	NNP
cord-306904-8iteddug	342	8	al	al	NNP
cord-306904-8iteddug	342	9	.	.	NNP
cord-306904-8iteddug	342	10	showed	show	VBD
cord-306904-8iteddug	342	11	that	that	IN
cord-306904-8iteddug	342	12	this	this	DT
cord-306904-8iteddug	342	13	"	"	``
cord-306904-8iteddug	342	14	part	part	NN
cord-306904-8iteddug	342	15	of	of	IN
cord-306904-8iteddug	342	16	the	the	DT
cord-306904-8iteddug	342	17	preceding	precede	VBG
cord-306904-8iteddug	342	18	region	region	NN
cord-306904-8iteddug	342	19	of	of	IN
cord-306904-8iteddug	342	20	unknown	unknown	JJ
cord-306904-8iteddug	342	21	structure	structure	NN
cord-306904-8iteddug	342	22	"	"	''
cord-306904-8iteddug	342	23	corresponds	correspond	VBZ
cord-306904-8iteddug	342	24	to	to	IN
cord-306904-8iteddug	342	25	a	a	DT
cord-306904-8iteddug	342	26	previously	previously	RB
cord-306904-8iteddug	342	27	unresolved	unresolved	JJ
cord-306904-8iteddug	342	28	a	a	DT
cord-306904-8iteddug	342	29	2helix	2helix	CD
cord-306904-8iteddug	342	30	(	(	-LRB-
cord-306904-8iteddug	342	31	residues	residue	NNS
cord-306904-8iteddug	342	32	95	95	CD
cord-306904-8iteddug	342	33	-	-	HYPH
cord-306904-8iteddug	342	34	104	104	CD
cord-306904-8iteddug	342	35	)	)	-RRB-
cord-306904-8iteddug	342	36	in	in	IN
cord-306904-8iteddug	342	37	the	the	DT
cord-306904-8iteddug	342	38	wild	wild	JJ
cord-306904-8iteddug	342	39	-	-	HYPH
cord-306904-8iteddug	342	40	type	type	NN
cord-306904-8iteddug	342	41	RyR2A.	ryr2a.	NN
cord-306904-8iteddug	342	42	113	113	CD
cord-306904-8iteddug	343	1	Curiously	curiously	RB
cord-306904-8iteddug	343	2	,	,	,
cord-306904-8iteddug	343	3	this	this	DT
cord-306904-8iteddug	343	4	a	a	DT
cord-306904-8iteddug	343	5	-	-	HYPH
cord-306904-8iteddug	343	6	helix	helix	NN
cord-306904-8iteddug	343	7	undergoes	undergo	VBZ
cord-306904-8iteddug	343	8	structural	structural	JJ
cord-306904-8iteddug	343	9	transformation	transformation	NN
cord-306904-8iteddug	343	10	to	to	IN
cord-306904-8iteddug	343	11	a	a	DT
cord-306904-8iteddug	343	12	b	b	NN
cord-306904-8iteddug	343	13	-	-	HYPH
cord-306904-8iteddug	343	14	strand	strand	NN
cord-306904-8iteddug	343	15	,	,	,
cord-306904-8iteddug	343	16	thereby	thereby	RB
cord-306904-8iteddug	343	17	rescuing	rescue	VBG
cord-306904-8iteddug	343	18	the	the	DT
cord-306904-8iteddug	343	19	b	b	NN
cord-306904-8iteddug	343	20	-	-	HYPH
cord-306904-8iteddug	343	21	strand	strand	NN
cord-306904-8iteddug	343	22	deleted	delete	VBN
cord-306904-8iteddug	343	23	in	in	IN
cord-306904-8iteddug	343	24	the	the	DT
cord-306904-8iteddug	343	25	RyR2AD3	RyR2AD3	NNP
cord-306904-8iteddug	343	26	due	due	IN
cord-306904-8iteddug	343	27	to	to	IN
cord-306904-8iteddug	343	28	the	the	DT
cord-306904-8iteddug	343	29	removal	removal	NN
cord-306904-8iteddug	343	30	of	of	IN
cord-306904-8iteddug	343	31	3	3	CD
cord-306904-8iteddug	343	32	in	in	IN
cord-306904-8iteddug	343	33	RyR2	ryr2	JJ
cord-306904-8iteddug	343	34	gene	gene	NN
cord-306904-8iteddug	343	35	.	.	.
cord-306904-8iteddug	344	1	Therefore	therefore	RB
cord-306904-8iteddug	344	2	,	,	,
cord-306904-8iteddug	344	3	the	the	DT
cord-306904-8iteddug	344	4	authors	author	NNS
cord-306904-8iteddug	344	5	revealed	reveal	VBD
cord-306904-8iteddug	344	6	that	that	IN
cord-306904-8iteddug	344	7	this	this	DT
cord-306904-8iteddug	344	8	newly	newly	RB
cord-306904-8iteddug	344	9	discovered	discover	VBD
cord-306904-8iteddug	344	10	a	a	DT
cord-306904-8iteddug	344	11	2	2	CD
cord-306904-8iteddug	344	12	-helix	-helix	NN
cord-306904-8iteddug	344	13	corresponds	correspond	NNS
cord-306904-8iteddug	344	14	to	to	IN
cord-306904-8iteddug	344	15	the	the	DT
cord-306904-8iteddug	344	16	region	region	NN
cord-306904-8iteddug	344	17	of	of	IN
cord-306904-8iteddug	344	18	missing	miss	VBG
cord-306904-8iteddug	344	19	electron	electron	NN
cord-306904-8iteddug	344	20	density	density	NN
cord-306904-8iteddug	344	21	in	in	IN
cord-306904-8iteddug	344	22	the	the	DT
cord-306904-8iteddug	344	23	earlier	early	JJR
cord-306904-8iteddug	344	24	crystal	crystal	NN
cord-306904-8iteddug	344	25	structures	structure	NNS
cord-306904-8iteddug	344	26	of	of	IN
cord-306904-8iteddug	344	27	the	the	DT
cord-306904-8iteddug	344	28	protein	protein	NN
cord-306904-8iteddug	344	29	,	,	,
cord-306904-8iteddug	344	30	is	be	VBZ
cord-306904-8iteddug	344	31	rather	rather	RB
cord-306904-8iteddug	344	32	dynamic	dynamic	JJ
cord-306904-8iteddug	344	33	,	,	,
cord-306904-8iteddug	344	34	exhibits	exhibit	VBZ
cord-306904-8iteddug	344	35	a	a	DT
cord-306904-8iteddug	344	36	greater	great	JJR
cord-306904-8iteddug	344	37	backbone	backbone	NN
cord-306904-8iteddug	344	38	RMSD	RMSD	NNP
cord-306904-8iteddug	344	39	compared	compare	VBN
cord-306904-8iteddug	344	40	to	to	IN
cord-306904-8iteddug	344	41	the	the	DT
cord-306904-8iteddug	344	42	remaining	remain	VBG
cord-306904-8iteddug	344	43	secondary	secondary	JJ
cord-306904-8iteddug	344	44	structure	structure	NN
cord-306904-8iteddug	344	45	elements	element	NNS
cord-306904-8iteddug	344	46	,	,	,
cord-306904-8iteddug	344	47	and	and	CC
cord-306904-8iteddug	344	48	is	be	VBZ
cord-306904-8iteddug	344	49	able	able	JJ
cord-306904-8iteddug	344	50	to	to	TO
cord-306904-8iteddug	344	51	undergo	undergo	VB
cord-306904-8iteddug	344	52	an	an	DT
cord-306904-8iteddug	344	53	a	a	DT
cord-306904-8iteddug	344	54	-	-	HYPH
cord-306904-8iteddug	344	55	to	to	IN
cord-306904-8iteddug	344	56	-	-	HYPH
cord-306904-8iteddug	344	57	b	b	NN
cord-306904-8iteddug	344	58	transition	transition	NN
cord-306904-8iteddug	344	59	after	after	IN
cord-306904-8iteddug	344	60	the	the	DT
cord-306904-8iteddug	344	61	deletion	deletion	NN
cord-306904-8iteddug	344	62	of	of	IN
cord-306904-8iteddug	344	63	residues	residue	NNS
cord-306904-8iteddug	344	64	N57-G91	N57-G91	NNP
cord-306904-8iteddug	344	65	in	in	IN
cord-306904-8iteddug	344	66	RyR2AD3	RyR2AD3	NNP
cord-306904-8iteddug	344	67	.	.	.
cord-306904-8iteddug	345	1	113	113	CD
cord-306904-8iteddug	346	1	In	in	IN
cord-306904-8iteddug	346	2	other	other	JJ
cord-306904-8iteddug	346	3	words	word	NNS
cord-306904-8iteddug	346	4	,	,	,
cord-306904-8iteddug	346	5	applying	apply	VBG
cord-306904-8iteddug	346	6	NMR	NMR	NNP
cord-306904-8iteddug	346	7	to	to	TO
cord-306904-8iteddug	346	8	look	look	VB
cord-306904-8iteddug	346	9	at	at	IN
cord-306904-8iteddug	346	10	the	the	DT
cord-306904-8iteddug	346	11	crystallographically	crystallographically	RB
cord-306904-8iteddug	346	12	invisible	invisible	JJ
cord-306904-8iteddug	346	13	region	region	NN
cord-306904-8iteddug	346	14	,	,	,
cord-306904-8iteddug	346	15	an	an	DT
cord-306904-8iteddug	346	16	important	important	JJ
cord-306904-8iteddug	346	17	chameleon	chameleon	NN
cord-306904-8iteddug	346	18	region	region	NN
cord-306904-8iteddug	346	19	was	be	VBD
cord-306904-8iteddug	346	20	discovered	discover	VBN
cord-306904-8iteddug	346	21	.	.	.
cord-306904-8iteddug	347	1	Although	although	IN
cord-306904-8iteddug	347	2	this	this	DT
cord-306904-8iteddug	347	3	chameleon	chameleon	NN
cord-306904-8iteddug	347	4	region	region	NN
cord-306904-8iteddug	347	5	is	be	VBZ
cord-306904-8iteddug	347	6	relatively	relatively	RB
cord-306904-8iteddug	347	7	small	small	JJ
cord-306904-8iteddug	347	8	,	,	,
cord-306904-8iteddug	347	9	it	-PRON-	PRP
cord-306904-8iteddug	347	10	is	be	VBZ
cord-306904-8iteddug	347	11	really	really	RB
cord-306904-8iteddug	347	12	mighty	mighty	JJ
cord-306904-8iteddug	347	13	,	,	,
cord-306904-8iteddug	347	14	with	with	IN
cord-306904-8iteddug	347	15	at	at	IN
cord-306904-8iteddug	347	16	least	least	JJS
cord-306904-8iteddug	347	17	some	some	DT
cord-306904-8iteddug	347	18	mightiness	mightiness	NN
cord-306904-8iteddug	347	19	being	be	VBG
cord-306904-8iteddug	347	20	attributed	attribute	VBN
cord-306904-8iteddug	347	21	to	to	IN
cord-306904-8iteddug	347	22	its	-PRON-	PRP$
cord-306904-8iteddug	347	23	intrinsically	intrinsically	RB
cord-306904-8iteddug	347	24	disordered	disordered	JJ
cord-306904-8iteddug	347	25	nature	nature	NN
cord-306904-8iteddug	347	26	.	.	.
cord-306904-8iteddug	348	1	Rodriguez	Rodriguez	NNP
cord-306904-8iteddug	348	2	et	et	NNP
cord-306904-8iteddug	348	3	al	al	NNP
cord-306904-8iteddug	348	4	.	.	NNP
cord-306904-8iteddug	348	5	used	use	VBD
cord-306904-8iteddug	348	6	complementary	complementary	JJ
cord-306904-8iteddug	348	7	biophysical	biophysical	JJ
cord-306904-8iteddug	348	8	techniques	technique	NNS
cord-306904-8iteddug	348	9	for	for	IN
cord-306904-8iteddug	348	10	examining	examine	VBG
cord-306904-8iteddug	348	11	the	the	DT
cord-306904-8iteddug	348	12	ATP	ATP	NNP
cord-306904-8iteddug	348	13	-	-	HYPH
cord-306904-8iteddug	348	14	induced	induce	VBN
cord-306904-8iteddug	348	15	conformational	conformational	JJ
cord-306904-8iteddug	348	16	switching	switching	NN
cord-306904-8iteddug	348	17	of	of	IN
cord-306904-8iteddug	348	18	the	the	DT
cord-306904-8iteddug	348	19	isolated	isolated	JJ
cord-306904-8iteddug	348	20	e	e	NN
cord-306904-8iteddug	348	21	subunit	subunit	NN
cord-306904-8iteddug	348	22	of	of	IN
cord-306904-8iteddug	348	23	the	the	DT
cord-306904-8iteddug	348	24	F	F	NNP
cord-306904-8iteddug	348	25	0	0	CD
cord-306904-8iteddug	348	26	F	F	NNP
cord-306904-8iteddug	348	27	1	1	CD
cord-306904-8iteddug	348	28	ATP	ATP	NNP
cord-306904-8iteddug	348	29	synthase	synthase	NN
cord-306904-8iteddug	348	30	from	from	IN
cord-306904-8iteddug	348	31	the	the	DT
cord-306904-8iteddug	348	32	thermophile	thermophile	NNP
cord-306904-8iteddug	348	33	Bacillus	Bacillus	NNP
cord-306904-8iteddug	348	34	PS3	PS3	NNP
cord-306904-8iteddug	348	35	(	(	-LRB-
cord-306904-8iteddug	348	36	Te	Te	NNP
cord-306904-8iteddug	348	37	)	)	-RRB-
cord-306904-8iteddug	348	38	.	.	.
cord-306904-8iteddug	349	1	118	118	CD
cord-306904-8iteddug	350	1	The	the	DT
cord-306904-8iteddug	350	2	authors	author	NNS
cord-306904-8iteddug	350	3	showed	show	VBD
cord-306904-8iteddug	350	4	that	that	IN
cord-306904-8iteddug	350	5	ATP	ATP	NNP
cord-306904-8iteddug	350	6	binding	binding	NN
cord-306904-8iteddug	350	7	induces	induce	VBZ
cord-306904-8iteddug	350	8	large	large	JJ
cord-306904-8iteddug	350	9	-	-	HYPH
cord-306904-8iteddug	350	10	scale	scale	NN
cord-306904-8iteddug	350	11	conformational	conformational	JJ
cord-306904-8iteddug	350	12	transition	transition	NN
cord-306904-8iteddug	350	13	consistent	consistent	JJ
cord-306904-8iteddug	350	14	with	with	IN
cord-306904-8iteddug	350	15	formation	formation	NN
cord-306904-8iteddug	350	16	of	of	IN
cord-306904-8iteddug	350	17	stable	stable	JJ
cord-306904-8iteddug	350	18	helical	helical	JJ
cord-306904-8iteddug	350	19	structure	structure	NN
cord-306904-8iteddug	350	20	in	in	IN
cord-306904-8iteddug	350	21	the	the	DT
cord-306904-8iteddug	350	22	isolated	isolate	VBN
cord-306904-8iteddug	350	23	Te	Te	NNP
cord-306904-8iteddug	350	24	.	.	.
cord-306904-8iteddug	351	1	118	118	CD
cord-306904-8iteddug	352	1	Based	base	VBN
cord-306904-8iteddug	352	2	on	on	IN
cord-306904-8iteddug	352	3	the	the	DT
cord-306904-8iteddug	352	4	complimentary	complimentary	JJ
cord-306904-8iteddug	352	5	hydrogen	hydrogen	NN
cord-306904-8iteddug	352	6	/	/	SYM
cord-306904-8iteddug	352	7	deuterium	deuterium	NN
cord-306904-8iteddug	352	8	exchange	exchange	NN
cord-306904-8iteddug	352	9	(	(	-LRB-
cord-306904-8iteddug	352	10	HDX	HDX	NNP
cord-306904-8iteddug	352	11	)	)	-RRB-
cord-306904-8iteddug	352	12	mass	mass	NNP
cord-306904-8iteddug	352	13	spectrometry	spectrometry	NN
cord-306904-8iteddug	352	14	analysis	analysis	NN
cord-306904-8iteddug	352	15	it	-PRON-	PRP
cord-306904-8iteddug	352	16	has	have	VBZ
cord-306904-8iteddug	352	17	been	be	VBN
cord-306904-8iteddug	352	18	concluded	conclude	VBN
cord-306904-8iteddug	352	19	that	that	IN
cord-306904-8iteddug	352	20	this	this	DT
cord-306904-8iteddug	352	21	transition	transition	NN
cord-306904-8iteddug	352	22	is	be	VBZ
cord-306904-8iteddug	352	23	accompanied	accompany	VBN
cord-306904-8iteddug	352	24	by	by	IN
cord-306904-8iteddug	352	25	a	a	DT
cord-306904-8iteddug	352	26	pronounced	pronounce	VBN
cord-306904-8iteddug	352	27	stabilization	stabilization	NN
cord-306904-8iteddug	352	28	in	in	IN
cord-306904-8iteddug	352	29	the	the	DT
cord-306904-8iteddug	352	30	vicinity	vicinity	NN
cord-306904-8iteddug	352	31	of	of	IN
cord-306904-8iteddug	352	32	the	the	DT
cord-306904-8iteddug	352	33	ATP	ATP	NNP
cord-306904-8iteddug	352	34	-	-	HYPH
cord-306904-8iteddug	352	35	binding	bind	VBG
cord-306904-8iteddug	352	36	pocket	pocket	NN
cord-306904-8iteddug	352	37	.	.	.
cord-306904-8iteddug	353	1	118	118	CD
cord-306904-8iteddug	354	1	Structurally	structurally	RB
cord-306904-8iteddug	354	2	,	,	,
cord-306904-8iteddug	354	3	the	the	DT
cord-306904-8iteddug	354	4	e	e	NN
cord-306904-8iteddug	354	5	subunit	subunit	NN
cord-306904-8iteddug	354	6	consists	consist	VBZ
cord-306904-8iteddug	354	7	of	of	IN
cord-306904-8iteddug	354	8	a	a	DT
cord-306904-8iteddug	354	9	b	b	NN
cord-306904-8iteddug	354	10	-	-	HYPH
cord-306904-8iteddug	354	11	sandwich	sandwich	NN
cord-306904-8iteddug	354	12	and	and	CC
cord-306904-8iteddug	354	13	2	2	CD
cord-306904-8iteddug	354	14	C	c	NN
cord-306904-8iteddug	354	15	-	-	HYPH
cord-306904-8iteddug	354	16	terminal	terminal	NN
cord-306904-8iteddug	354	17	helices	helix	NNS
cord-306904-8iteddug	354	18	,	,	,
cord-306904-8iteddug	354	19	a1	a1	NNP
cord-306904-8iteddug	354	20	and	and	CC
cord-306904-8iteddug	354	21	a2	a2	NNP
cord-306904-8iteddug	354	22	.	.	.
cord-306904-8iteddug	355	1	119	119	CD
cord-306904-8iteddug	356	1	Curiously	curiously	RB
cord-306904-8iteddug	356	2	,	,	,
cord-306904-8iteddug	356	3	this	this	DT
cord-306904-8iteddug	356	4	protein	protein	NN
cord-306904-8iteddug	356	5	is	be	VBZ
cord-306904-8iteddug	356	6	able	able	JJ
cord-306904-8iteddug	356	7	to	to	TO
cord-306904-8iteddug	356	8	undergo	undergo	VB
cord-306904-8iteddug	356	9	dramatic	dramatic	JJ
cord-306904-8iteddug	356	10	structural	structural	JJ
cord-306904-8iteddug	356	11	rearrangements	rearrangement	NNS
cord-306904-8iteddug	356	12	from	from	IN
cord-306904-8iteddug	356	13	a	a	DT
cord-306904-8iteddug	356	14	compact	compact	JJ
cord-306904-8iteddug	356	15	structure	structure	NN
cord-306904-8iteddug	356	16	in	in	IN
cord-306904-8iteddug	356	17	the	the	DT
cord-306904-8iteddug	356	18	non	non	JJ
cord-306904-8iteddug	356	19	-	-	JJ
cord-306904-8iteddug	356	20	bound	bound	JJ
cord-306904-8iteddug	356	21	form	form	NN
cord-306904-8iteddug	356	22	(	(	-LRB-
cord-306904-8iteddug	356	23	see	see	VB
cord-306904-8iteddug	356	24	Fig	Fig	NNP
cord-306904-8iteddug	356	25	.	.	.
cord-306904-8iteddug	357	1	10A	10a	LS
cord-306904-8iteddug	357	2	;	;	:
cord-306904-8iteddug	357	3	PDB	PDB	NNP
cord-306904-8iteddug	357	4	ID	ID	NNP
cord-306904-8iteddug	357	5	:	:	:
cord-306904-8iteddug	358	1	1AQT	1aqt	LS
cord-306904-8iteddug	358	2	)	)	-RRB-
cord-306904-8iteddug	358	3	119	119	CD
cord-306904-8iteddug	358	4	to	to	IN
cord-306904-8iteddug	358	5	a	a	DT
cord-306904-8iteddug	358	6	highly	highly	RB
cord-306904-8iteddug	358	7	extended	extend	VBN
cord-306904-8iteddug	358	8	open	open	JJ
cord-306904-8iteddug	358	9	form	form	NN
cord-306904-8iteddug	358	10	in	in	IN
cord-306904-8iteddug	358	11	a	a	DT
cord-306904-8iteddug	358	12	complex	complex	NN
cord-306904-8iteddug	358	13	with	with	IN
cord-306904-8iteddug	358	14	other	other	JJ
cord-306904-8iteddug	358	15	subunits	subunit	NNS
cord-306904-8iteddug	358	16	of	of	IN
cord-306904-8iteddug	358	17	the	the	DT
cord-306904-8iteddug	358	18	bacterial	bacterial	JJ
cord-306904-8iteddug	358	19	F	F	NNP
cord-306904-8iteddug	358	20	1	1	CD
cord-306904-8iteddug	358	21	complex	complex	NN
cord-306904-8iteddug	358	22	(	(	-LRB-
cord-306904-8iteddug	358	23	see	see	VB
cord-306904-8iteddug	358	24	Fig	Fig	NNP
cord-306904-8iteddug	358	25	.	.	.
cord-306904-8iteddug	359	1	10B	10b	LS
cord-306904-8iteddug	359	2	;	;	:
cord-306904-8iteddug	359	3	PDB	PDB	NNP
cord-306904-8iteddug	359	4	ID	ID	NNP
cord-306904-8iteddug	359	5	:	:	:
cord-306904-8iteddug	359	6	3OAA	3oaa	LS
cord-306904-8iteddug	359	7	)	)	-RRB-
cord-306904-8iteddug	359	8	.	.	.
cord-306904-8iteddug	360	1	The	the	DT
cord-306904-8iteddug	360	2	ability	ability	NN
cord-306904-8iteddug	360	3	of	of	IN
cord-306904-8iteddug	360	4	the	the	DT
cord-306904-8iteddug	360	5	e	e	NN
cord-306904-8iteddug	360	6	subunit	subunit	NN
cord-306904-8iteddug	360	7	to	to	TO
cord-306904-8iteddug	360	8	undergo	undergo	VB
cord-306904-8iteddug	360	9	large	large	JJ
cord-306904-8iteddug	360	10	conformational	conformational	JJ
cord-306904-8iteddug	360	11	change	change	NN
cord-306904-8iteddug	360	12	associated	associate	VBN
cord-306904-8iteddug	360	13	with	with	IN
cord-306904-8iteddug	360	14	binding	bind	VBG
cord-306904-8iteddug	360	15	to	to	IN
cord-306904-8iteddug	360	16	the	the	DT
cord-306904-8iteddug	360	17	F	F	NNP
cord-306904-8iteddug	360	18	1	1	CD
cord-306904-8iteddug	360	19	complex	complex	NN
cord-306904-8iteddug	360	20	is	be	VBZ
cord-306904-8iteddug	360	21	determined	determine	VBN
cord-306904-8iteddug	360	22	by	by	IN
cord-306904-8iteddug	360	23	the	the	DT
cord-306904-8iteddug	360	24	presence	presence	NN
cord-306904-8iteddug	360	25	of	of	IN
cord-306904-8iteddug	360	26	long	long	JJ
cord-306904-8iteddug	360	27	IDPR	IDPR	NNP
cord-306904-8iteddug	360	28	at	at	IN
cord-306904-8iteddug	360	29	the	the	DT
cord-306904-8iteddug	360	30	C	C	NNP
cord-306904-8iteddug	360	31	-	-	HYPH
cord-306904-8iteddug	360	32	terminal	terminal	NN
cord-306904-8iteddug	360	33	region	region	NN
cord-306904-8iteddug	360	34	(	(	-LRB-
cord-306904-8iteddug	360	35	see	see	VB
cord-306904-8iteddug	360	36	Fig	Fig	NNP
cord-306904-8iteddug	360	37	.	.	.
cord-306904-8iteddug	361	1	10C	10c	LS
cord-306904-8iteddug	361	2	;	;	:
cord-306904-8iteddug	361	3	UniProt	UniProt	NNP
cord-306904-8iteddug	361	4	ID	ID	NNP
cord-306904-8iteddug	361	5	:	:	:
cord-306904-8iteddug	361	6	P0A6E6	p0a6e6	NN
cord-306904-8iteddug	361	7	)	)	-RRB-
cord-306904-8iteddug	361	8	.	.	.
cord-306904-8iteddug	362	1	Simon	Simon	NNP
cord-306904-8iteddug	362	2	et	et	NNP
cord-306904-8iteddug	362	3	al	al	NNP
cord-306904-8iteddug	362	4	.	.	.
cord-306904-8iteddug	362	5	investigated	investigate	VBD
cord-306904-8iteddug	362	6	functional	functional	JJ
cord-306904-8iteddug	362	7	peculiarities	peculiarity	NNS
cord-306904-8iteddug	362	8	of	of	IN
cord-306904-8iteddug	362	9	the	the	DT
cord-306904-8iteddug	362	10	Candida	Candida	NNP
cord-306904-8iteddug	362	11	albicans	albican	NNS
cord-306904-8iteddug	362	12	cyclin	cyclin	VBP
cord-306904-8iteddug	362	13	CaPcl5	capcl5	CD
cord-306904-8iteddug	362	14	.	.	.
cord-306904-8iteddug	363	1	120	120	CD
cord-306904-8iteddug	364	1	The	the	DT
cord-306904-8iteddug	364	2	authors	author	NNS
cord-306904-8iteddug	364	3	showed	show	VBD
cord-306904-8iteddug	364	4	that	that	IN
cord-306904-8iteddug	364	5	the	the	DT
cord-306904-8iteddug	364	6	activation	activation	NN
cord-306904-8iteddug	364	7	of	of	IN
cord-306904-8iteddug	364	8	the	the	DT
cord-306904-8iteddug	364	9	cyclin	cyclin	NN
cord-306904-8iteddug	364	10	-	-	HYPH
cord-306904-8iteddug	364	11	dependent	dependent	JJ
cord-306904-8iteddug	364	12	kinase	kinase	NN
cord-306904-8iteddug	364	13	Pho85	Pho85	NNP
cord-306904-8iteddug	364	14	that	that	WDT
cord-306904-8iteddug	364	15	induces	induce	VBZ
cord-306904-8iteddug	364	16	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	364	17	of	of	IN
cord-306904-8iteddug	364	18	the	the	DT
cord-306904-8iteddug	364	19	transcription	transcription	NN
cord-306904-8iteddug	364	20	factor	factor	NN
cord-306904-8iteddug	364	21	CaGcn4	cagcn4	NN
cord-306904-8iteddug	364	22	is	be	VBZ
cord-306904-8iteddug	364	23	controlled	control	VBN
cord-306904-8iteddug	364	24	via	via	IN
cord-306904-8iteddug	364	25	the	the	DT
cord-306904-8iteddug	364	26	specific	specific	JJ
cord-306904-8iteddug	364	27	binding	binding	NN
cord-306904-8iteddug	364	28	of	of	IN
cord-306904-8iteddug	364	29	CaPcl5	capcl5	NN
cord-306904-8iteddug	364	30	to	to	IN
cord-306904-8iteddug	364	31	Pho85	Pho85	NNP
cord-306904-8iteddug	364	32	.	.	.
cord-306904-8iteddug	365	1	Furthermore	furthermore	RB
cord-306904-8iteddug	365	2	,	,	,
cord-306904-8iteddug	365	3	it	-PRON-	PRP
cord-306904-8iteddug	365	4	is	be	VBZ
cord-306904-8iteddug	365	5	shown	show	VBN
cord-306904-8iteddug	365	6	that	that	IN
cord-306904-8iteddug	365	7	CaPcl5	CaPcl5	NNP
cord-306904-8iteddug	365	8	induces	induce	VBZ
cord-306904-8iteddug	365	9	its	-PRON-	PRP$
cord-306904-8iteddug	365	10	own	own	JJ
cord-306904-8iteddug	365	11	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	365	12	at	at	IN
cord-306904-8iteddug	365	13	2	2	CD
cord-306904-8iteddug	365	14	adjacent	adjacent	JJ
cord-306904-8iteddug	365	15	sites	site	NNS
cord-306904-8iteddug	365	16	in	in	IN
cord-306904-8iteddug	365	17	the	the	DT
cord-306904-8iteddug	365	18	N	n	CD
cord-306904-8iteddug	365	19	-	-	HYPH
cord-306904-8iteddug	365	20	terminal	terminal	NN
cord-306904-8iteddug	365	21	region	region	NN
cord-306904-8iteddug	365	22	of	of	IN
cord-306904-8iteddug	365	23	the	the	DT
cord-306904-8iteddug	365	24	protein	protein	NN
cord-306904-8iteddug	365	25	and	and	CC
cord-306904-8iteddug	365	26	that	that	IN
cord-306904-8iteddug	365	27	this	this	DT
cord-306904-8iteddug	365	28	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	365	29	causes	cause	VBZ
cord-306904-8iteddug	365	30	degradation	degradation	NN
cord-306904-8iteddug	365	31	of	of	IN
cord-306904-8iteddug	365	32	the	the	DT
cord-306904-8iteddug	365	33	cyclin	cyclin	NN
cord-306904-8iteddug	365	34	in	in	IN
cord-306904-8iteddug	365	35	vivo	vivo	NN
cord-306904-8iteddug	365	36	,	,	,
cord-306904-8iteddug	365	37	whereas	whereas	IN
cord-306904-8iteddug	365	38	in	in	FW
cord-306904-8iteddug	365	39	vitro	vitro	FW
cord-306904-8iteddug	365	40	studies	study	NNS
cord-306904-8iteddug	365	41	indicated	indicate	VBD
cord-306904-8iteddug	365	42	that	that	IN
cord-306904-8iteddug	365	43	this	this	DT
cord-306904-8iteddug	365	44	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	365	45	was	be	VBD
cord-306904-8iteddug	365	46	accompanied	accompany	VBN
cord-306904-8iteddug	365	47	by	by	IN
cord-306904-8iteddug	365	48	a	a	DT
cord-306904-8iteddug	365	49	loss	loss	NN
cord-306904-8iteddug	365	50	of	of	IN
cord-306904-8iteddug	365	51	specific	specific	JJ
cord-306904-8iteddug	365	52	substrate	substrate	NN
cord-306904-8iteddug	365	53	recognition	recognition	NN
cord-306904-8iteddug	365	54	thereby	thereby	RB
cord-306904-8iteddug	365	55	representing	represent	VBG
cord-306904-8iteddug	365	56	a	a	DT
cord-306904-8iteddug	365	57	novel	novel	JJ
cord-306904-8iteddug	365	58	mechanism	mechanism	NN
cord-306904-8iteddug	365	59	for	for	IN
cord-306904-8iteddug	365	60	limiting	limit	VBG
cord-306904-8iteddug	365	61	cyclin	cyclin	NN
cord-306904-8iteddug	365	62	activity	activity	NN
cord-306904-8iteddug	365	63	.	.	.
cord-306904-8iteddug	366	1	120	120	CD
cord-306904-8iteddug	366	2	Activity	activity	NN
cord-306904-8iteddug	366	3	of	of	IN
cord-306904-8iteddug	366	4	cyclin	cyclin	NN
cord-306904-8iteddug	366	5	-	-	HYPH
cord-306904-8iteddug	366	6	dependent	dependent	JJ
cord-306904-8iteddug	366	7	kinases	kinase	NNS
cord-306904-8iteddug	366	8	(	(	-LRB-
cord-306904-8iteddug	366	9	CDKs	CDKs	NNP
cord-306904-8iteddug	366	10	)	)	-RRB-
cord-306904-8iteddug	366	11	is	be	VBZ
cord-306904-8iteddug	366	12	regulated	regulate	VBN
cord-306904-8iteddug	366	13	via	via	IN
cord-306904-8iteddug	366	14	binding	bind	VBG
cord-306904-8iteddug	366	15	of	of	IN
cord-306904-8iteddug	366	16	ancillary	ancillary	JJ
cord-306904-8iteddug	366	17	subunits	subunit	NNS
cord-306904-8iteddug	366	18	,	,	,
cord-306904-8iteddug	366	19	the	the	DT
cord-306904-8iteddug	366	20	cyclins	cyclin	NNS
cord-306904-8iteddug	366	21	,	,	,
cord-306904-8iteddug	366	22	121	121	CD
cord-306904-8iteddug	366	23	which	which	WDT
cord-306904-8iteddug	366	24	also	also	RB
cord-306904-8iteddug	366	25	participate	participate	VBP
cord-306904-8iteddug	366	26	in	in	IN
cord-306904-8iteddug	366	27	targeting	target	VBG
cord-306904-8iteddug	366	28	the	the	DT
cord-306904-8iteddug	366	29	kinase	kinase	NN
cord-306904-8iteddug	366	30	to	to	IN
cord-306904-8iteddug	366	31	specific	specific	JJ
cord-306904-8iteddug	366	32	substrates	substrate	NNS
cord-306904-8iteddug	366	33	.	.	.
cord-306904-8iteddug	367	1	122	122	CD
cord-306904-8iteddug	367	2	Similar	similar	JJ
cord-306904-8iteddug	367	3	to	to	IN
cord-306904-8iteddug	367	4	other	other	JJ
cord-306904-8iteddug	367	5	members	member	NNS
cord-306904-8iteddug	367	6	of	of	IN
cord-306904-8iteddug	367	7	the	the	DT
cord-306904-8iteddug	367	8	CDK	CDK	NNP
cord-306904-8iteddug	367	9	family	family	NN
cord-306904-8iteddug	367	10	,	,	,
cord-306904-8iteddug	367	11	a	a	DT
cord-306904-8iteddug	367	12	yeast	yeast	NN
cord-306904-8iteddug	367	13	(	(	-LRB-
cord-306904-8iteddug	367	14	Saccharomyces	Saccharomyces	NNP
cord-306904-8iteddug	367	15	cerevisiae	cerevisiae	NNS
cord-306904-8iteddug	367	16	)	)	-RRB-
cord-306904-8iteddug	368	1	CDK	CDK	NNP
cord-306904-8iteddug	368	2	Pho85	Pho85	NNP
cord-306904-8iteddug	368	3	can	can	MD
cord-306904-8iteddug	368	4	bind	bind	VB
cord-306904-8iteddug	368	5	up	up	RP
cord-306904-8iteddug	368	6	to	to	TO
cord-306904-8iteddug	368	7	10	10	CD
cord-306904-8iteddug	368	8	different	different	JJ
cord-306904-8iteddug	368	9	Pho85	Pho85	NNP
cord-306904-8iteddug	368	10	cyclins	cyclin	NNS
cord-306904-8iteddug	368	11	(	(	-LRB-
cord-306904-8iteddug	368	12	Pcls	Pcls	NNP
cord-306904-8iteddug	368	13	)	)	-RRB-
cord-306904-8iteddug	368	14	,	,	,
cord-306904-8iteddug	368	15	123	123	CD
cord-306904-8iteddug	368	16	which	which	WDT
cord-306904-8iteddug	368	17	defines	define	VBZ
cord-306904-8iteddug	368	18	the	the	DT
cord-306904-8iteddug	368	19	ability	ability	NN
cord-306904-8iteddug	368	20	of	of	IN
cord-306904-8iteddug	368	21	this	this	DT
cord-306904-8iteddug	368	22	CDK	CDK	NNP
cord-306904-8iteddug	368	23	to	to	TO
cord-306904-8iteddug	368	24	phosphorylate	phosphorylate	VB
cord-306904-8iteddug	368	25	different	different	JJ
cord-306904-8iteddug	368	26	substrates	substrate	NNS
cord-306904-8iteddug	368	27	leading	lead	VBG
cord-306904-8iteddug	368	28	to	to	IN
cord-306904-8iteddug	368	29	a	a	DT
cord-306904-8iteddug	368	30	wide	wide	JJ
cord-306904-8iteddug	368	31	range	range	NN
cord-306904-8iteddug	368	32	of	of	IN
cord-306904-8iteddug	368	33	Pho85	Pho85	NNP
cord-306904-8iteddug	368	34	functions	function	NNS
cord-306904-8iteddug	368	35	in	in	IN
cord-306904-8iteddug	368	36	cellular	cellular	JJ
cord-306904-8iteddug	368	37	regulation	regulation	NN
cord-306904-8iteddug	368	38	.	.	.
cord-306904-8iteddug	369	1	Among	among	IN
cord-306904-8iteddug	369	2	various	various	JJ
cord-306904-8iteddug	369	3	regulatory	regulatory	JJ
cord-306904-8iteddug	369	4	functions	function	NNS
cord-306904-8iteddug	369	5	of	of	IN
cord-306904-8iteddug	369	6	Pho85	Pho85	NNP
cord-306904-8iteddug	369	7	complexed	complexed	JJ
cord-306904-8iteddug	369	8	with	with	IN
cord-306904-8iteddug	369	9	different	different	JJ
cord-306904-8iteddug	369	10	cyclins	cyclin	NNS
cord-306904-8iteddug	369	11	,	,	,
cord-306904-8iteddug	369	12	is	be	VBZ
cord-306904-8iteddug	369	13	the	the	DT
cord-306904-8iteddug	369	14	Pho85	Pho85	NNP
cord-306904-8iteddug	369	15	/	/	SYM
cord-306904-8iteddug	369	16	Pcl5-driven	Pcl5-driven	NNP
cord-306904-8iteddug	369	17	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	369	18	of	of	IN
cord-306904-8iteddug	369	19	the	the	DT
cord-306904-8iteddug	369	20	bZIP	bzip	CD
cord-306904-8iteddug	369	21	transcription	transcription	NN
cord-306904-8iteddug	369	22	factor	factor	NN
cord-306904-8iteddug	369	23	Gcn4	Gcn4	NNP
cord-306904-8iteddug	369	24	leading	lead	VBG
cord-306904-8iteddug	369	25	to	to	IN
cord-306904-8iteddug	369	26	its	-PRON-	PRP$
cord-306904-8iteddug	369	27	degradation	degradation	NN
cord-306904-8iteddug	369	28	.	.	.
cord-306904-8iteddug	370	1	124	124	CD
cord-306904-8iteddug	371	1	Curiously	curiously	RB
cord-306904-8iteddug	371	2	,	,	,
cord-306904-8iteddug	371	3	it	-PRON-	PRP
cord-306904-8iteddug	371	4	was	be	VBD
cord-306904-8iteddug	371	5	shown	show	VBN
cord-306904-8iteddug	371	6	that	that	IN
cord-306904-8iteddug	371	7	cyclin	cyclin	NN
cord-306904-8iteddug	371	8	Pcl5	Pcl5	NNP
cord-306904-8iteddug	371	9	coevolved	coevolve	VBD
cord-306904-8iteddug	371	10	with	with	IN
cord-306904-8iteddug	371	11	its	-PRON-	PRP$
cord-306904-8iteddug	371	12	substrate	substrate	NN
cord-306904-8iteddug	371	13	Gcn4	Gcn4	NNP
cord-306904-8iteddug	371	14	,	,	,
cord-306904-8iteddug	371	15	and	and	CC
cord-306904-8iteddug	371	16	in	in	IN
cord-306904-8iteddug	371	17	the	the	DT
cord-306904-8iteddug	371	18	pathogenic	pathogenic	JJ
cord-306904-8iteddug	371	19	yeast	yeast	NN
cord-306904-8iteddug	371	20	Candida	candida	NN
cord-306904-8iteddug	371	21	albicans	albican	NNS
cord-306904-8iteddug	371	22	,	,	,
cord-306904-8iteddug	371	23	degradation	degradation	NN
cord-306904-8iteddug	371	24	of	of	IN
cord-306904-8iteddug	371	25	CaGcn4	cagcn4	NN
cord-306904-8iteddug	371	26	depends	depend	VBZ
cord-306904-8iteddug	371	27	on	on	IN
cord-306904-8iteddug	371	28	CaPcl5	capcl5	NN
cord-306904-8iteddug	371	29	.	.	.
cord-306904-8iteddug	372	1	125	125	CD
cord-306904-8iteddug	372	2	Mutagenic	mutagenic	JJ
cord-306904-8iteddug	372	3	analysis	analysis	NN
cord-306904-8iteddug	372	4	of	of	IN
cord-306904-8iteddug	372	5	the	the	DT
cord-306904-8iteddug	372	6	CaPcl5	capcl5	JJ
cord-306904-8iteddug	372	7	(	(	-LRB-
cord-306904-8iteddug	372	8	Uni	Uni	NNP
cord-306904-8iteddug	372	9	-	-	HYPH
cord-306904-8iteddug	372	10	Prot	Prot	NNP
cord-306904-8iteddug	372	11	ID	ID	NNP
cord-306904-8iteddug	372	12	:	:	:
cord-306904-8iteddug	373	1	Q5AK08	Q5AK08	NNP
cord-306904-8iteddug	373	2	)	)	-RRB-
cord-306904-8iteddug	373	3	revealed	reveal	VBD
cord-306904-8iteddug	373	4	2	2	CD
cord-306904-8iteddug	373	5	potential	potential	JJ
cord-306904-8iteddug	373	6	CDK	CDK	NNP
cord-306904-8iteddug	373	7	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	373	8	sites	site	NNS
cord-306904-8iteddug	373	9	located	locate	VBN
cord-306904-8iteddug	373	10	in	in	IN
cord-306904-8iteddug	373	11	the	the	DT
cord-306904-8iteddug	373	12	N	n	CD
cord-306904-8iteddug	373	13	-	-	HYPH
cord-306904-8iteddug	373	14	terminal	terminal	NN
cord-306904-8iteddug	373	15	segment	segment	NN
cord-306904-8iteddug	373	16	,	,	,
cord-306904-8iteddug	373	17	at	at	IN
cord-306904-8iteddug	373	18	positions	position	NNS
cord-306904-8iteddug	373	19	38	38	CD
cord-306904-8iteddug	373	20	and	and	CC
cord-306904-8iteddug	373	21	43	43	CD
cord-306904-8iteddug	373	22	.	.	.
cord-306904-8iteddug	374	1	120	120	CD
cord-306904-8iteddug	374	2	Figure	figure	NN
cord-306904-8iteddug	374	3	11	11	CD
cord-306904-8iteddug	374	4	shows	show	NNS
cord-306904-8iteddug	374	5	that	that	IN
cord-306904-8iteddug	374	6	both	both	DT
cord-306904-8iteddug	374	7	of	of	IN
cord-306904-8iteddug	374	8	these	these	DT
cord-306904-8iteddug	374	9	phosphorylated	phosphorylated	JJ
cord-306904-8iteddug	374	10	sites	site	NNS
cord-306904-8iteddug	374	11	are	be	VBP
cord-306904-8iteddug	374	12	located	locate	VBN
cord-306904-8iteddug	374	13	within	within	IN
cord-306904-8iteddug	374	14	the	the	DT
cord-306904-8iteddug	374	15	disordered	disordered	JJ
cord-306904-8iteddug	374	16	region	region	NN
cord-306904-8iteddug	374	17	,	,	,
cord-306904-8iteddug	374	18	providing	provide	VBG
cord-306904-8iteddug	374	19	further	further	JJ
cord-306904-8iteddug	374	20	illustration	illustration	NN
cord-306904-8iteddug	374	21	for	for	IN
cord-306904-8iteddug	374	22	an	an	DT
cord-306904-8iteddug	374	23	important	important	JJ
cord-306904-8iteddug	374	24	notion	notion	NN
cord-306904-8iteddug	374	25	stating	state	VBG
cord-306904-8iteddug	374	26	that	that	IN
cord-306904-8iteddug	374	27	sites	site	NNS
cord-306904-8iteddug	374	28	of	of	IN
cord-306904-8iteddug	374	29	posttranslational	posttranslational	JJ
cord-306904-8iteddug	374	30	modifications	modification	NNS
cord-306904-8iteddug	374	31	in	in	IN
cord-306904-8iteddug	374	32	proteins	protein	NNS
cord-306904-8iteddug	374	33	are	be	VBP
cord-306904-8iteddug	374	34	commonly	commonly	RB
cord-306904-8iteddug	374	35	located	locate	VBN
cord-306904-8iteddug	374	36	within	within	IN
cord-306904-8iteddug	374	37	the	the	DT
cord-306904-8iteddug	374	38	disordered	disordered	JJ
cord-306904-8iteddug	374	39	regions	region	NNS
cord-306904-8iteddug	374	40	.	.	.
cord-306904-8iteddug	375	1	126	126	CD
cord-306904-8iteddug	375	2	Nuclear	nuclear	JJ
cord-306904-8iteddug	375	3	localization	localization	NN
cord-306904-8iteddug	375	4	of	of	IN
cord-306904-8iteddug	375	5	the	the	DT
cord-306904-8iteddug	375	6	alternatively	alternatively	RB
cord-306904-8iteddug	375	7	spliced	splice	VBN
cord-306904-8iteddug	375	8	sirtuin-2	sirtuin-2	NNP
cord-306904-8iteddug	375	9	isoform	isoform	NN
cord-306904-8iteddug	375	10	Rack	Rack	NNP
cord-306904-8iteddug	375	11	et	et	FW
cord-306904-8iteddug	375	12	al	al	NNP
cord-306904-8iteddug	375	13	.	.	.
cord-306904-8iteddug	376	1	described	describe	VBD
cord-306904-8iteddug	376	2	a	a	DT
cord-306904-8iteddug	376	3	discovery	discovery	NN
cord-306904-8iteddug	376	4	of	of	IN
cord-306904-8iteddug	376	5	a	a	DT
cord-306904-8iteddug	376	6	new	new	JJ
cord-306904-8iteddug	376	7	alternatively	alternatively	RB
cord-306904-8iteddug	376	8	spliced	splice	VBN
cord-306904-8iteddug	376	9	isoform	isoform	NN
cord-306904-8iteddug	376	10	of	of	IN
cord-306904-8iteddug	376	11	the	the	DT
cord-306904-8iteddug	376	12	human	human	NN
cord-306904-8iteddug	376	13	sirtuin-2	sirtuin-2	NNP
cord-306904-8iteddug	376	14	.	.	.
cord-306904-8iteddug	377	1	127	127	CD
cord-306904-8iteddug	378	1	The	the	DT
cord-306904-8iteddug	378	2	new	new	JJ
cord-306904-8iteddug	378	3	isoform	isoform	NN
cord-306904-8iteddug	378	4	results	result	VBZ
cord-306904-8iteddug	378	5	from	from	IN
cord-306904-8iteddug	378	6	skipping	skip	VBG
cord-306904-8iteddug	378	7	of	of	IN
cord-306904-8iteddug	378	8	exons	exon	NNS
cord-306904-8iteddug	378	9	2	2	CD
cord-306904-8iteddug	378	10	-	-	SYM
cord-306904-8iteddug	378	11	4	4	CD
cord-306904-8iteddug	378	12	in	in	IN
cord-306904-8iteddug	378	13	the	the	DT
cord-306904-8iteddug	378	14	SIRT2	sirt2	NN
cord-306904-8iteddug	378	15	gene	gene	NN
cord-306904-8iteddug	378	16	.	.	.
cord-306904-8iteddug	379	1	127	127	CD
cord-306904-8iteddug	379	2	Sirtuin-2	Sirtuin-2	NNPS
cord-306904-8iteddug	379	3	is	be	VBZ
cord-306904-8iteddug	379	4	a	a	DT
cord-306904-8iteddug	379	5	member	member	NN
cord-306904-8iteddug	379	6	of	of	IN
cord-306904-8iteddug	379	7	a	a	DT
cord-306904-8iteddug	379	8	large	large	JJ
cord-306904-8iteddug	379	9	family	family	NN
cord-306904-8iteddug	379	10	of	of	IN
cord-306904-8iteddug	379	11	protein	protein	NN
cord-306904-8iteddug	379	12	-	-	HYPH
cord-306904-8iteddug	379	13	modifying	modify	VBG
cord-306904-8iteddug	379	14	enzymes	enzyme	NNS
cord-306904-8iteddug	379	15	,	,	,
cord-306904-8iteddug	379	16	NAD	NAD	NNP
cord-306904-8iteddug	379	17	Cdependent	Cdependent	NNP
cord-306904-8iteddug	379	18	deacetylases	deacetylase	NNS
cord-306904-8iteddug	379	19	,	,	,
cord-306904-8iteddug	379	20	which	which	WDT
cord-306904-8iteddug	379	21	are	be	VBP
cord-306904-8iteddug	379	22	highly	highly	RB
cord-306904-8iteddug	379	23	conserved	conserve	VBN
cord-306904-8iteddug	379	24	throughout	throughout	IN
cord-306904-8iteddug	379	25	bacteria	bacteria	NNS
cord-306904-8iteddug	379	26	,	,	,
cord-306904-8iteddug	379	27	archaea	archaea	NNS
cord-306904-8iteddug	379	28	,	,	,
cord-306904-8iteddug	379	29	and	and	CC
cord-306904-8iteddug	379	30	eukaryotes	eukaryote	NNS
cord-306904-8iteddug	379	31	,	,	,
cord-306904-8iteddug	379	32	and	and	CC
cord-306904-8iteddug	379	33	are	be	VBP
cord-306904-8iteddug	379	34	heavily	heavily	RB
cord-306904-8iteddug	379	35	involved	involve	VBN
cord-306904-8iteddug	379	36	in	in	IN
cord-306904-8iteddug	379	37	modulation	modulation	NN
cord-306904-8iteddug	379	38	of	of	IN
cord-306904-8iteddug	379	39	various	various	JJ
cord-306904-8iteddug	379	40	cellular	cellular	JJ
cord-306904-8iteddug	379	41	processes	process	NNS
cord-306904-8iteddug	379	42	ranging	range	VBG
cord-306904-8iteddug	379	43	from	from	IN
cord-306904-8iteddug	379	44	metabolic	metabolic	JJ
cord-306904-8iteddug	379	45	homeostasis	homeostasis	NN
cord-306904-8iteddug	379	46	,	,	,
cord-306904-8iteddug	379	47	to	to	IN
cord-306904-8iteddug	379	48	cell	cell	NN
cord-306904-8iteddug	379	49	cycle	cycle	NN
cord-306904-8iteddug	379	50	control	control	NN
cord-306904-8iteddug	379	51	,	,	,
cord-306904-8iteddug	379	52	to	to	IN
cord-306904-8iteddug	379	53	development	development	NN
cord-306904-8iteddug	379	54	,	,	,
cord-306904-8iteddug	379	55	and	and	CC
cord-306904-8iteddug	379	56	to	to	TO
cord-306904-8iteddug	379	57	chromatin	chromatin	VB
cord-306904-8iteddug	379	58	organization	organization	NN
cord-306904-8iteddug	379	59	.	.	.
cord-306904-8iteddug	380	1	[	[	-LRB-
cord-306904-8iteddug	380	2	128	128	CD
cord-306904-8iteddug	380	3	]	]	-RRB-
cord-306904-8iteddug	380	4	[	[	-LRB-
cord-306904-8iteddug	380	5	129	129	CD
cord-306904-8iteddug	380	6	]	]	-RRB-
cord-306904-8iteddug	380	7	[	[	-LRB-
cord-306904-8iteddug	380	8	130	130	CD
cord-306904-8iteddug	380	9	]	]	-RRB-
cord-306904-8iteddug	380	10	[	[	-LRB-
cord-306904-8iteddug	380	11	131	131	CD
cord-306904-8iteddug	380	12	]	]	-RRB-
cord-306904-8iteddug	381	1	[	[	-LRB-
cord-306904-8iteddug	381	2	132	132	CD
cord-306904-8iteddug	381	3	]	]	-RRB-
cord-306904-8iteddug	382	1	[	[	-LRB-
cord-306904-8iteddug	382	2	133	133	CD
cord-306904-8iteddug	382	3	]	]	-RRB-
cord-306904-8iteddug	383	1	In	in	IN
cord-306904-8iteddug	383	2	their	-PRON-	PRP$
cord-306904-8iteddug	383	3	turn	turn	NN
cord-306904-8iteddug	383	4	,	,	,
cord-306904-8iteddug	383	5	the	the	DT
cord-306904-8iteddug	383	6	numerous	numerous	JJ
cord-306904-8iteddug	383	7	activities	activity	NNS
cord-306904-8iteddug	383	8	of	of	IN
cord-306904-8iteddug	383	9	sirtuins	sirtuin	NNS
cord-306904-8iteddug	383	10	are	be	VBP
cord-306904-8iteddug	383	11	regulated	regulate	VBN
cord-306904-8iteddug	383	12	by	by	IN
cord-306904-8iteddug	383	13	alternative	alternative	JJ
cord-306904-8iteddug	383	14	splicing	splicing	NN
cord-306904-8iteddug	383	15	,	,	,
cord-306904-8iteddug	383	16	modulation	modulation	NN
cord-306904-8iteddug	383	17	of	of	IN
cord-306904-8iteddug	383	18	expression	expression	NN
cord-306904-8iteddug	383	19	levels	level	NNS
cord-306904-8iteddug	383	20	,	,	,
cord-306904-8iteddug	383	21	posttranslational	posttranslational	JJ
cord-306904-8iteddug	383	22	modifications	modification	NNS
cord-306904-8iteddug	383	23	or	or	CC
cord-306904-8iteddug	383	24	subcellular	subcellular	JJ
cord-306904-8iteddug	383	25	compartmentalization	compartmentalization	NN
cord-306904-8iteddug	383	26	.	.	.
cord-306904-8iteddug	384	1	[	[	-LRB-
cord-306904-8iteddug	384	2	134	134	CD
cord-306904-8iteddug	384	3	]	]	-RRB-
cord-306904-8iteddug	384	4	[	[	-LRB-
cord-306904-8iteddug	384	5	135	135	CD
cord-306904-8iteddug	384	6	]	]	-RRB-
cord-306904-8iteddug	384	7	[	[	-LRB-
cord-306904-8iteddug	384	8	136	136	CD
cord-306904-8iteddug	384	9	]	]	-RRB-
cord-306904-8iteddug	384	10	[	[	-LRB-
cord-306904-8iteddug	384	11	137	137	CD
cord-306904-8iteddug	384	12	]	]	-RRB-
cord-306904-8iteddug	385	1	In	in	IN
cord-306904-8iteddug	385	2	humans	human	NNS
cord-306904-8iteddug	385	3	,	,	,
cord-306904-8iteddug	385	4	there	there	EX
cord-306904-8iteddug	385	5	are	be	VBP
cord-306904-8iteddug	385	6	7	7	CD
cord-306904-8iteddug	385	7	sirtuin	sirtuin	NN
cord-306904-8iteddug	385	8	homologues	homologue	NNS
cord-306904-8iteddug	385	9	with	with	IN
cord-306904-8iteddug	385	10	distinct	distinct	JJ
cord-306904-8iteddug	385	11	cellular	cellular	JJ
cord-306904-8iteddug	385	12	locations	location	NNS
cord-306904-8iteddug	385	13	.	.	.
cord-306904-8iteddug	386	1	For	for	IN
cord-306904-8iteddug	386	2	example	example	NN
cord-306904-8iteddug	386	3	,	,	,
cord-306904-8iteddug	386	4	Sirt1	Sirt1	NNP
cord-306904-8iteddug	386	5	,	,	,
cord-306904-8iteddug	386	6	Sirt6	Sirt6	NNP
cord-306904-8iteddug	386	7	and	and	CC
cord-306904-8iteddug	386	8	Sirt7	Sirt7	NNP
cord-306904-8iteddug	386	9	are	be	VBP
cord-306904-8iteddug	386	10	primarily	primarily	RB
cord-306904-8iteddug	386	11	localized	localize	VBN
cord-306904-8iteddug	386	12	to	to	IN
cord-306904-8iteddug	386	13	the	the	DT
cord-306904-8iteddug	386	14	nucleus	nucleus	NN
cord-306904-8iteddug	386	15	,	,	,
cord-306904-8iteddug	386	16	whereas	whereas	IN
cord-306904-8iteddug	386	17	Sirt3	Sirt3	NNS
cord-306904-8iteddug	386	18	,	,	,
cord-306904-8iteddug	387	1	Sirt4	sirt4	VB
cord-306904-8iteddug	387	2	and	and	CC
cord-306904-8iteddug	387	3	Sirt5	sirt5	NN
cord-306904-8iteddug	387	4	are	be	VBP
cord-306904-8iteddug	387	5	mitochondrial	mitochondrial	JJ
cord-306904-8iteddug	387	6	proteins	protein	NNS
cord-306904-8iteddug	387	7	,	,	,
cord-306904-8iteddug	387	8	and	and	CC
cord-306904-8iteddug	388	1	Sirt2	Sirt2	NNP
cord-306904-8iteddug	388	2	is	be	VBZ
cord-306904-8iteddug	388	3	believed	believe	VBN
cord-306904-8iteddug	388	4	to	to	TO
cord-306904-8iteddug	388	5	have	have	VB
cord-306904-8iteddug	388	6	a	a	DT
cord-306904-8iteddug	388	7	predominant	predominant	JJ
cord-306904-8iteddug	388	8	cytosolic	cytosolic	JJ
cord-306904-8iteddug	388	9	localization	localization	NN
cord-306904-8iteddug	388	10	.	.	.
cord-306904-8iteddug	389	1	138	138	CD
cord-306904-8iteddug	390	1	Earlier	early	RBR
cord-306904-8iteddug	390	2	,	,	,
cord-306904-8iteddug	390	3	4	4	CD
cord-306904-8iteddug	390	4	variants	variant	NNS
cord-306904-8iteddug	390	5	of	of	IN
cord-306904-8iteddug	390	6	human	human	JJ
cord-306904-8iteddug	390	7	SIRT2	sirt2	NN
cord-306904-8iteddug	390	8	gene	gene	NN
cord-306904-8iteddug	390	9	were	be	VBD
cord-306904-8iteddug	390	10	reported	report	VBN
cord-306904-8iteddug	390	11	,	,	,
cord-306904-8iteddug	390	12	with	with	IN
cord-306904-8iteddug	390	13	alternative	alternative	JJ
cord-306904-8iteddug	390	14	splicing	splicing	NN
cord-306904-8iteddug	390	15	affecting	affect	VBG
cord-306904-8iteddug	390	16	the	the	DT
cord-306904-8iteddug	390	17	N	n	CD
cord-306904-8iteddug	390	18	-	-	HYPH
cord-306904-8iteddug	390	19	terminal	terminal	JJ
cord-306904-8iteddug	390	20	part	part	NN
cord-306904-8iteddug	390	21	of	of	IN
cord-306904-8iteddug	390	22	the	the	DT
cord-306904-8iteddug	390	23	sirtuin-2	sirtuin-2	NNP
cord-306904-8iteddug	390	24	protein	protein	NN
cord-306904-8iteddug	390	25	in	in	IN
cord-306904-8iteddug	390	26	2	2	CD
cord-306904-8iteddug	390	27	isoforms	isoform	NNS
cord-306904-8iteddug	390	28	(	(	-LRB-
cord-306904-8iteddug	390	29	residues	residue	NNS
cord-306904-8iteddug	390	30	1	1	CD
cord-306904-8iteddug	390	31	-	-	SYM
cord-306904-8iteddug	390	32	37	37	CD
cord-306904-8iteddug	390	33	are	be	VBP
cord-306904-8iteddug	390	34	missing	miss	VBG
cord-306904-8iteddug	390	35	in	in	IN
cord-306904-8iteddug	390	36	the	the	DT
cord-306904-8iteddug	390	37	isoform-2	isoform-2	NNP
cord-306904-8iteddug	390	38	and	and	CC
cord-306904-8iteddug	390	39	the	the	DT
cord-306904-8iteddug	390	40	residues	residue	NNS
cord-306904-8iteddug	391	1	1	1	LS
cord-306904-8iteddug	391	2	-	-	SYM
cord-306904-8iteddug	391	3	38	38	CD
cord-306904-8iteddug	391	4	(	(	-LRB-
cord-306904-8iteddug	391	5	MAEPDPSHPLETQAGKV	MAEPDPSHPLETQAGKV	NNP
cord-306904-8iteddug	391	6	-	-	HYPH
cord-306904-8iteddug	391	7	QEAQDSDSDSEGGAAGGEADM	QEAQDSDSDSEGGAAGGEADM	NNP
cord-306904-8iteddug	391	8	)	)	-RRB-
cord-306904-8iteddug	391	9	are	be	VBP
cord-306904-8iteddug	391	10	substituted	substitute	VBN
cord-306904-8iteddug	391	11	by	by	IN
cord-306904-8iteddug	391	12	residues	residue	NNS
cord-306904-8iteddug	391	13	MPLAECPSC	MPLAECPSC	NNP
cord-306904-8iteddug	391	14	-	-	HYPH
cord-306904-8iteddug	391	15	RCLSSFRSV	RCLSSFRSV	NNP
cord-306904-8iteddug	391	16	in	in	IN
cord-306904-8iteddug	391	17	the	the	DT
cord-306904-8iteddug	391	18	isoform-3	isoform-3	NNP
cord-306904-8iteddug	391	19	)	)	-RRB-
cord-306904-8iteddug	391	20	,	,	,
cord-306904-8iteddug	391	21	and	and	CC
cord-306904-8iteddug	391	22	with	with	IN
cord-306904-8iteddug	391	23	the	the	DT
cord-306904-8iteddug	391	24	isoform-4	isoform-4	NNP
cord-306904-8iteddug	391	25	possessing	possess	VBG
cord-306904-8iteddug	391	26	changes	change	NNS
cord-306904-8iteddug	391	27	at	at	IN
cord-306904-8iteddug	391	28	the	the	DT
cord-306904-8iteddug	391	29	C	C	NNP
cord-306904-8iteddug	391	30	-	-	HYPH
cord-306904-8iteddug	391	31	terminus	terminus	NN
cord-306904-8iteddug	391	32	,	,	,
cord-306904-8iteddug	391	33	where	where	WRB
cord-306904-8iteddug	391	34	residues	residue	VBZ
cord-306904-8iteddug	391	35	266	266	CD
cord-306904-8iteddug	391	36	-	-	HYPH
cord-306904-8iteddug	391	37	271	271	CD
cord-306904-8iteddug	391	38	(	(	-LRB-
cord-306904-8iteddug	391	39	VQPFAS	VQPFAS	NNP
cord-306904-8iteddug	391	40	)	)	-RRB-
cord-306904-8iteddug	391	41	are	be	VBP
cord-306904-8iteddug	391	42	substituted	substitute	VBN
cord-306904-8iteddug	391	43	by	by	IN
cord-306904-8iteddug	391	44	GRGLAG	GRGLAG	NNP
cord-306904-8iteddug	391	45	,	,	,
cord-306904-8iteddug	391	46	and	and	CC
cord-306904-8iteddug	391	47	residues	residue	VBZ
cord-306904-8iteddug	391	48	272	272	CD
cord-306904-8iteddug	391	49	-	-	SYM
cord-306904-8iteddug	391	50	389	389	CD
cord-306904-8iteddug	391	51	are	be	VBP
cord-306904-8iteddug	391	52	missing	miss	VBG
cord-306904-8iteddug	391	53	.	.	.
cord-306904-8iteddug	392	1	These	these	DT
cord-306904-8iteddug	392	2	isoforms	isoform	NNS
cord-306904-8iteddug	392	3	contain	contain	VBP
cord-306904-8iteddug	392	4	a	a	DT
cord-306904-8iteddug	392	5	leucine	leucine	NN
cord-306904-8iteddug	392	6	-	-	HYPH
cord-306904-8iteddug	392	7	rich	rich	JJ
cord-306904-8iteddug	392	8	nuclear	nuclear	JJ
cord-306904-8iteddug	392	9	export	export	NN
cord-306904-8iteddug	392	10	signal	signal	NN
cord-306904-8iteddug	392	11	(	(	-LRB-
cord-306904-8iteddug	392	12	NES	NES	NNP
cord-306904-8iteddug	392	13	)	)	-RRB-
cord-306904-8iteddug	392	14	within	within	IN
cord-306904-8iteddug	392	15	their	-PRON-	PRP$
cord-306904-8iteddug	392	16	N	n	CD
cord-306904-8iteddug	392	17	-	-	HYPH
cord-306904-8iteddug	392	18	terminal	terminal	NN
cord-306904-8iteddug	392	19	region	region	NN
cord-306904-8iteddug	392	20	which	which	WDT
cord-306904-8iteddug	392	21	mediate	mediate	VBP
cord-306904-8iteddug	392	22	their	-PRON-	PRP$
cord-306904-8iteddug	392	23	cytosolic	cytosolic	JJ
cord-306904-8iteddug	392	24	localization	localization	NN
cord-306904-8iteddug	392	25	139	139	CD
cord-306904-8iteddug	392	26	where	where	WRB
cord-306904-8iteddug	392	27	they	-PRON-	PRP
cord-306904-8iteddug	392	28	have	have	VBP
cord-306904-8iteddug	392	29	numerous	numerous	JJ
cord-306904-8iteddug	392	30	functions	function	NNS
cord-306904-8iteddug	392	31	.	.	.
cord-306904-8iteddug	393	1	A	a	DT
cord-306904-8iteddug	393	2	recent	recent	JJ
cord-306904-8iteddug	393	3	finding	find	VBG
cord-306904-8iteddug	393	4	a	a	DT
cord-306904-8iteddug	393	5	new	new	JJ
cord-306904-8iteddug	393	6	isoform-5	isoform-5	NNP
cord-306904-8iteddug	393	7	with	with	IN
cord-306904-8iteddug	393	8	the	the	DT
cord-306904-8iteddug	393	9	predominant	predominant	JJ
cord-306904-8iteddug	393	10	nuclear	nuclear	JJ
cord-306904-8iteddug	393	11	localization	localization	NN
cord-306904-8iteddug	393	12	helped	help	VBD
cord-306904-8iteddug	393	13	to	to	TO
cord-306904-8iteddug	393	14	resolve	resolve	VB
cord-306904-8iteddug	393	15	an	an	DT
cord-306904-8iteddug	393	16	apparent	apparent	JJ
cord-306904-8iteddug	393	17	contradiction	contradiction	NN
cord-306904-8iteddug	393	18	between	between	IN
cord-306904-8iteddug	393	19	the	the	DT
cord-306904-8iteddug	393	20	predominant	predominant	JJ
cord-306904-8iteddug	393	21	cytosolic	cytosolic	JJ
cord-306904-8iteddug	393	22	localization	localization	NN
cord-306904-8iteddug	393	23	of	of	IN
cord-306904-8iteddug	393	24	this	this	DT
cord-306904-8iteddug	393	25	protein	protein	NN
cord-306904-8iteddug	393	26	and	and	CC
cord-306904-8iteddug	393	27	the	the	DT
cord-306904-8iteddug	393	28	existence	existence	NN
cord-306904-8iteddug	393	29	of	of	IN
cord-306904-8iteddug	393	30	multiple	multiple	JJ
cord-306904-8iteddug	393	31	nuclear	nuclear	JJ
cord-306904-8iteddug	393	32	functions	function	NNS
cord-306904-8iteddug	393	33	.	.	.
cord-306904-8iteddug	394	1	127	127	CD
cord-306904-8iteddug	395	1	The	the	DT
cord-306904-8iteddug	395	2	newly	newly	RB
cord-306904-8iteddug	395	3	discovered	discover	VBN
cord-306904-8iteddug	395	4	alternative	alternative	JJ
cord-306904-8iteddug	395	5	splicing	splicing	NN
cord-306904-8iteddug	395	6	event	event	NN
cord-306904-8iteddug	395	7	results	result	NNS
cord-306904-8iteddug	395	8	in	in	IN
cord-306904-8iteddug	395	9	the	the	DT
cord-306904-8iteddug	395	10	substitution	substitution	NN
cord-306904-8iteddug	395	11	of	of	IN
cord-306904-8iteddug	395	12	the	the	DT
cord-306904-8iteddug	395	13	codons	codon	NNS
cord-306904-8iteddug	395	14	for	for	IN
cord-306904-8iteddug	395	15	amino	amino	JJ
cord-306904-8iteddug	395	16	acids	acid	NNS
cord-306904-8iteddug	395	17	6	6	CD
cord-306904-8iteddug	395	18	-	-	SYM
cord-306904-8iteddug	395	19	76	76	CD
cord-306904-8iteddug	395	20	of	of	IN
cord-306904-8iteddug	395	21	the	the	DT
cord-306904-8iteddug	395	22	full	full	JJ
cord-306904-8iteddug	395	23	-	-	HYPH
cord-306904-8iteddug	395	24	length	length	NN
cord-306904-8iteddug	395	25	ORF	ORF	NNP
cord-306904-8iteddug	395	26	of	of	IN
cord-306904-8iteddug	395	27	isoform-1	isoform-1	NNP
cord-306904-8iteddug	395	28	by	by	IN
cord-306904-8iteddug	395	29	an	an	DT
cord-306904-8iteddug	395	30	arginine	arginine	NN
cord-306904-8iteddug	395	31	codon	codon	NN
cord-306904-8iteddug	395	32	in	in	IN
cord-306904-8iteddug	395	33	a	a	DT
cord-306904-8iteddug	395	34	new	new	JJ
cord-306904-8iteddug	395	35	isoform	isoform	NN
cord-306904-8iteddug	395	36	.	.	.
cord-306904-8iteddug	396	1	This	this	DT
cord-306904-8iteddug	396	2	isoform-5	isoform-5	NNP
cord-306904-8iteddug	396	3	is	be	VBZ
cord-306904-8iteddug	396	4	predominantly	predominantly	RB
cord-306904-8iteddug	396	5	localized	localize	VBN
cord-306904-8iteddug	396	6	in	in	IN
cord-306904-8iteddug	396	7	the	the	DT
cord-306904-8iteddug	396	8	nucleus	nucleus	NN
cord-306904-8iteddug	396	9	,	,	,
cord-306904-8iteddug	396	10	does	do	VBZ
cord-306904-8iteddug	396	11	not	not	RB
cord-306904-8iteddug	396	12	exhibit	exhibit	VB
cord-306904-8iteddug	396	13	detectable	detectable	JJ
cord-306904-8iteddug	396	14	deacetylase	deacetylase	NN
cord-306904-8iteddug	396	15	activity	activity	NN
cord-306904-8iteddug	396	16	,	,	,
cord-306904-8iteddug	396	17	but	but	CC
cord-306904-8iteddug	396	18	is	be	VBZ
cord-306904-8iteddug	396	19	properly	properly	RB
cord-306904-8iteddug	396	20	folded	fold	VBN
cord-306904-8iteddug	396	21	and	and	CC
cord-306904-8iteddug	396	22	retains	retain	VBZ
cord-306904-8iteddug	396	23	the	the	DT
cord-306904-8iteddug	396	24	ability	ability	NN
cord-306904-8iteddug	396	25	to	to	TO
cord-306904-8iteddug	396	26	bind	bind	VB
cord-306904-8iteddug	396	27	p300	p300	NNP
cord-306904-8iteddug	396	28	.	.	.
cord-306904-8iteddug	397	1	127	127	CD
cord-306904-8iteddug	398	1	It	-PRON-	PRP
cord-306904-8iteddug	398	2	has	have	VBZ
cord-306904-8iteddug	398	3	been	be	VBN
cord-306904-8iteddug	398	4	established	establish	VBN
cord-306904-8iteddug	398	5	that	that	IN
cord-306904-8iteddug	398	6	the	the	DT
cord-306904-8iteddug	398	7	protein	protein	NN
cord-306904-8iteddug	398	8	segments	segment	NNS
cord-306904-8iteddug	398	9	affected	affect	VBN
cord-306904-8iteddug	398	10	by	by	IN
cord-306904-8iteddug	398	11	alternative	alternative	JJ
cord-306904-8iteddug	398	12	splicing	splicing	NN
cord-306904-8iteddug	398	13	are	be	VBP
cord-306904-8iteddug	398	14	most	most	RBS
cord-306904-8iteddug	398	15	often	often	RB
cord-306904-8iteddug	398	16	intrinsically	intrinsically	RB
cord-306904-8iteddug	398	17	disordered	disordered	JJ
cord-306904-8iteddug	398	18	,	,	,
cord-306904-8iteddug	398	19	suggesting	suggest	VBG
cord-306904-8iteddug	398	20	that	that	IN
cord-306904-8iteddug	398	21	alternative	alternative	JJ
cord-306904-8iteddug	398	22	splicing	splicing	NN
cord-306904-8iteddug	398	23	enables	enable	VBZ
cord-306904-8iteddug	398	24	functional	functional	JJ
cord-306904-8iteddug	398	25	and	and	CC
cord-306904-8iteddug	398	26	regulatory	regulatory	JJ
cord-306904-8iteddug	398	27	diversity	diversity	NN
cord-306904-8iteddug	398	28	while	while	IN
cord-306904-8iteddug	398	29	avoiding	avoid	VBG
cord-306904-8iteddug	398	30	structural	structural	JJ
cord-306904-8iteddug	398	31	complications	complication	NNS
cord-306904-8iteddug	398	32	associated	associate	VBN
cord-306904-8iteddug	398	33	with	with	IN
cord-306904-8iteddug	398	34	the	the	DT
cord-306904-8iteddug	398	35	deletion	deletion	NN
cord-306904-8iteddug	398	36	of	of	IN
cord-306904-8iteddug	398	37	portions	portion	NNS
cord-306904-8iteddug	398	38	of	of	IN
cord-306904-8iteddug	398	39	the	the	DT
cord-306904-8iteddug	398	40	well	well	RB
cord-306904-8iteddug	398	41	-	-	HYPH
cord-306904-8iteddug	398	42	folded	fold	VBN
cord-306904-8iteddug	398	43	proteins	protein	NNS
cord-306904-8iteddug	398	44	.	.	.
cord-306904-8iteddug	399	1	140	140	CD
cord-306904-8iteddug	400	1	In	in	IN
cord-306904-8iteddug	400	2	line	line	NN
cord-306904-8iteddug	400	3	with	with	IN
cord-306904-8iteddug	400	4	these	these	DT
cord-306904-8iteddug	400	5	observations	observation	NNS
cord-306904-8iteddug	400	6	,	,	,
cord-306904-8iteddug	400	7	later	later	RB
cord-306904-8iteddug	400	8	studies	study	NNS
cord-306904-8iteddug	400	9	revealed	reveal	VBD
cord-306904-8iteddug	400	10	that	that	IN
cord-306904-8iteddug	400	11	the	the	DT
cord-306904-8iteddug	400	12	tissue	tissue	NN
cord-306904-8iteddug	400	13	-	-	HYPH
cord-306904-8iteddug	400	14	specific	specific	JJ
cord-306904-8iteddug	400	15	protein	protein	NN
cord-306904-8iteddug	400	16	segments	segment	NNS
cord-306904-8iteddug	400	17	produced	produce	VBN
cord-306904-8iteddug	400	18	by	by	IN
cord-306904-8iteddug	400	19	alternative	alternative	JJ
cord-306904-8iteddug	400	20	splicing	splicing	NN
cord-306904-8iteddug	400	21	often	often	RB
cord-306904-8iteddug	400	22	contain	contain	VBP
cord-306904-8iteddug	400	23	disordered	disordered	JJ
cord-306904-8iteddug	400	24	regions	region	NNS
cord-306904-8iteddug	400	25	,	,	,
cord-306904-8iteddug	400	26	are	be	VBP
cord-306904-8iteddug	400	27	enriched	enrich	VBN
cord-306904-8iteddug	400	28	in	in	IN
cord-306904-8iteddug	400	29	posttranslational	posttranslational	JJ
cord-306904-8iteddug	400	30	modification	modification	NN
cord-306904-8iteddug	400	31	sites	site	NNS
cord-306904-8iteddug	400	32	,	,	,
cord-306904-8iteddug	400	33	and	and	CC
cord-306904-8iteddug	400	34	frequently	frequently	RB
cord-306904-8iteddug	400	35	embed	embed	VBP
cord-306904-8iteddug	400	36	conserved	conserve	VBN
cord-306904-8iteddug	400	37	binding	binding	NN
cord-306904-8iteddug	400	38	motifs	motif	NNS
cord-306904-8iteddug	400	39	.	.	.
cord-306904-8iteddug	401	1	141	141	CD
cord-306904-8iteddug	401	2	Also	also	RB
cord-306904-8iteddug	401	3	,	,	,
cord-306904-8iteddug	401	4	it	-PRON-	PRP
cord-306904-8iteddug	401	5	was	be	VBD
cord-306904-8iteddug	401	6	proposed	propose	VBN
cord-306904-8iteddug	401	7	that	that	IN
cord-306904-8iteddug	401	8	alternative	alternative	JJ
cord-306904-8iteddug	401	9	splicing	splicing	NN
cord-306904-8iteddug	401	10	of	of	IN
cord-306904-8iteddug	401	11	intrinsically	intrinsically	RB
cord-306904-8iteddug	401	12	disordered	disordered	JJ
cord-306904-8iteddug	401	13	regions	region	NNS
cord-306904-8iteddug	401	14	containing	contain	VBG
cord-306904-8iteddug	401	15	linear	linear	JJ
cord-306904-8iteddug	401	16	interaction	interaction	NN
cord-306904-8iteddug	401	17	motifs	motif	NNS
cord-306904-8iteddug	401	18	and/or	and/or	CC
cord-306904-8iteddug	401	19	post	post	JJ
cord-306904-8iteddug	401	20	-	-	JJ
cord-306904-8iteddug	401	21	translational	translational	JJ
cord-306904-8iteddug	401	22	modification	modification	NN
cord-306904-8iteddug	401	23	sites	site	NNS
cord-306904-8iteddug	401	24	results	result	NNS
cord-306904-8iteddug	401	25	in	in	IN
cord-306904-8iteddug	401	26	complete	complete	JJ
cord-306904-8iteddug	401	27	rewiring	rewiring	NN
cord-306904-8iteddug	401	28	of	of	IN
cord-306904-8iteddug	401	29	protein	protein	NN
cord-306904-8iteddug	401	30	interactions	interaction	NNS
cord-306904-8iteddug	401	31	.	.	.
cord-306904-8iteddug	402	1	142	142	CD
cord-306904-8iteddug	402	2	Figure	figure	NN
cord-306904-8iteddug	402	3	12	12	CD
cord-306904-8iteddug	402	4	shows	show	NNS
cord-306904-8iteddug	402	5	that	that	IN
cord-306904-8iteddug	402	6	in	in	IN
cord-306904-8iteddug	402	7	agreement	agreement	NN
cord-306904-8iteddug	402	8	with	with	IN
cord-306904-8iteddug	402	9	these	these	DT
cord-306904-8iteddug	402	10	earlier	early	JJR
cord-306904-8iteddug	402	11	observations	observation	NNS
cord-306904-8iteddug	402	12	the	the	DT
cord-306904-8iteddug	402	13	alternatively	alternatively	RB
cord-306904-8iteddug	402	14	spliced	splice	VBN
cord-306904-8iteddug	402	15	isoform-5	isoform-5	NNP
cord-306904-8iteddug	402	16	of	of	IN
cord-306904-8iteddug	402	17	human	human	NN
cord-306904-8iteddug	402	18	sirtuin-2	sirtuin-2	NNP
cord-306904-8iteddug	402	19	differs	differ	VBZ
cord-306904-8iteddug	402	20	from	from	IN
cord-306904-8iteddug	402	21	the	the	DT
cord-306904-8iteddug	402	22	canonical	canonical	JJ
cord-306904-8iteddug	402	23	isoform	isoform	NN
cord-306904-8iteddug	402	24	(	(	-LRB-
cord-306904-8iteddug	402	25	UniProt	UniProt	NNP
cord-306904-8iteddug	402	26	ID	ID	NNP
cord-306904-8iteddug	402	27	:	:	:
cord-306904-8iteddug	402	28	Q8IXJ6	Q8IXJ6	NNP
cord-306904-8iteddug	402	29	)	)	-RRB-
cord-306904-8iteddug	402	30	by	by	IN
cord-306904-8iteddug	402	31	lacking	lack	VBG
cord-306904-8iteddug	402	32	the	the	DT
cord-306904-8iteddug	402	33	intrinsically	intrinsically	RB
cord-306904-8iteddug	402	34	disordered	disordered	JJ
cord-306904-8iteddug	402	35	Nterminal	Nterminal	NNP
cord-306904-8iteddug	402	36	tail	tail	NN
cord-306904-8iteddug	402	37	(	(	-LRB-
cord-306904-8iteddug	402	38	cf	cf	FW
cord-306904-8iteddug	402	39	.	.	.
cord-306904-8iteddug	402	40	Figs	fig	NNS
cord-306904-8iteddug	402	41	.	.	.
cord-306904-8iteddug	403	1	12A	12a	LS
cord-306904-8iteddug	403	2	and	and	CC
cord-306904-8iteddug	403	3	12B	12b	CD
cord-306904-8iteddug	403	4	)	)	-RRB-
cord-306904-8iteddug	403	5	.	.	.
cord-306904-8iteddug	404	1	Curiously	curiously	RB
cord-306904-8iteddug	404	2	,	,	,
cord-306904-8iteddug	404	3	the	the	DT
cord-306904-8iteddug	404	4	ANCHOR	anchor	NN
cord-306904-8iteddug	404	5	analysis	analysis	NN
cord-306904-8iteddug	404	6	15,16	15,16	CD
cord-306904-8iteddug	404	7	of	of	IN
cord-306904-8iteddug	404	8	the	the	DT
cord-306904-8iteddug	404	9	human	human	NN
cord-306904-8iteddug	404	10	sirtuin-2	sirtuin-2	NNP
cord-306904-8iteddug	404	11	revealed	reveal	VBD
cord-306904-8iteddug	404	12	that	that	IN
cord-306904-8iteddug	404	13	this	this	DT
cord-306904-8iteddug	404	14	alternative	alternative	JJ
cord-306904-8iteddug	404	15	splicing	splicing	NN
cord-306904-8iteddug	404	16	event	event	NN
cord-306904-8iteddug	404	17	removed	remove	VBD
cord-306904-8iteddug	404	18	2	2	CD
cord-306904-8iteddug	404	19	AiBSs	AiBSs	NNP
cord-306904-8iteddug	404	20	(	(	-LRB-
cord-306904-8iteddug	404	21	located	locate	VBN
cord-306904-8iteddug	404	22	at	at	IN
cord-306904-8iteddug	404	23	the	the	DT
cord-306904-8iteddug	404	24	residues	residue	NNS
cord-306904-8iteddug	404	25	1	1	CD
cord-306904-8iteddug	404	26	-	-	SYM
cord-306904-8iteddug	404	27	15	15	CD
cord-306904-8iteddug	404	28	and	and	CC
cord-306904-8iteddug	404	29	36	36	CD
cord-306904-8iteddug	404	30	-	-	SYM
cord-306904-8iteddug	404	31	49	49	CD
cord-306904-8iteddug	404	32	of	of	IN
cord-306904-8iteddug	404	33	the	the	DT
cord-306904-8iteddug	404	34	isoform-1	isoform-1	NNP
cord-306904-8iteddug	404	35	)	)	-RRB-
cord-306904-8iteddug	404	36	.	.	.
cord-306904-8iteddug	405	1	Therefore	therefore	RB
cord-306904-8iteddug	405	2	,	,	,
cord-306904-8iteddug	405	3	functionality	functionality	NN
cord-306904-8iteddug	405	4	of	of	IN
cord-306904-8iteddug	405	5	siruin-2	siruin-2	NNP
cord-306904-8iteddug	405	6	is	be	VBZ
cord-306904-8iteddug	405	7	modulated	modulate	VBN
cord-306904-8iteddug	405	8	by	by	IN
cord-306904-8iteddug	405	9	alternative	alternative	JJ
cord-306904-8iteddug	405	10	splicing	splicing	NN
cord-306904-8iteddug	405	11	that	that	WDT
cord-306904-8iteddug	405	12	removes	remove	VBZ
cord-306904-8iteddug	405	13	potential	potential	JJ
cord-306904-8iteddug	405	14	binding	bind	VBG
cord-306904-8iteddug	405	15	sites	site	NNS
cord-306904-8iteddug	405	16	from	from	IN
cord-306904-8iteddug	405	17	the	the	DT
cord-306904-8iteddug	405	18	disordered	disordered	JJ
cord-306904-8iteddug	405	19	region	region	NN
cord-306904-8iteddug	405	20	of	of	IN
cord-306904-8iteddug	405	21	this	this	DT
cord-306904-8iteddug	405	22	protein	protein	NN
cord-306904-8iteddug	405	23	.	.	.
cord-306904-8iteddug	406	1	Parker	Parker	NNP
cord-306904-8iteddug	406	2	et	et	NNP
cord-306904-8iteddug	406	3	al	al	NNP
cord-306904-8iteddug	406	4	.	.	NNP
cord-306904-8iteddug	406	5	investigated	investigate	VBD
cord-306904-8iteddug	406	6	the	the	DT
cord-306904-8iteddug	406	7	role	role	NN
cord-306904-8iteddug	406	8	of	of	IN
cord-306904-8iteddug	406	9	the	the	DT
cord-306904-8iteddug	406	10	amino	amino	NN
cord-306904-8iteddug	406	11	acid	acid	NN
cord-306904-8iteddug	406	12	sequence	sequence	NN
cord-306904-8iteddug	406	13	at	at	IN
cord-306904-8iteddug	406	14	the	the	DT
cord-306904-8iteddug	406	15	C	C	NNP
cord-306904-8iteddug	406	16	-	-	HYPH
cord-306904-8iteddug	406	17	terminal	terminal	NN
cord-306904-8iteddug	406	18	region	region	NN
cord-306904-8iteddug	406	19	of	of	IN
cord-306904-8iteddug	406	20	human	human	NN
cord-306904-8iteddug	406	21	semaphorin-3	semaphorin-3	NNP
cord-306904-8iteddug	406	22	in	in	IN
cord-306904-8iteddug	406	23	interaction	interaction	NN
cord-306904-8iteddug	406	24	of	of	IN
cord-306904-8iteddug	406	25	this	this	DT
cord-306904-8iteddug	406	26	protein	protein	NN
cord-306904-8iteddug	406	27	with	with	IN
cord-306904-8iteddug	406	28	neuropilin-1	neuropilin-1	NNP
cord-306904-8iteddug	406	29	.	.	.
cord-306904-8iteddug	407	1	143	143	CD
cord-306904-8iteddug	408	1	The	the	DT
cord-306904-8iteddug	408	2	neuropilin-1	neuropilin-1	NNP
cord-306904-8iteddug	408	3	is	be	VBZ
cord-306904-8iteddug	408	4	a	a	DT
cord-306904-8iteddug	408	5	member	member	NN
cord-306904-8iteddug	408	6	of	of	IN
cord-306904-8iteddug	408	7	the	the	DT
cord-306904-8iteddug	408	8	family	family	NN
cord-306904-8iteddug	408	9	of	of	IN
cord-306904-8iteddug	408	10	type	type	NN
cord-306904-8iteddug	408	11	I	-PRON-	PRP
cord-306904-8iteddug	408	12	transmembrane	transmembrane	NN
cord-306904-8iteddug	408	13	receptors	receptor	NNS
cord-306904-8iteddug	408	14	that	that	WDT
cord-306904-8iteddug	408	15	are	be	VBP
cord-306904-8iteddug	408	16	essential	essential	JJ
cord-306904-8iteddug	408	17	in	in	IN
cord-306904-8iteddug	408	18	development	development	NN
cord-306904-8iteddug	408	19	,	,	,
cord-306904-8iteddug	408	20	homeostasis	homeostasis	NN
cord-306904-8iteddug	408	21	,	,	,
cord-306904-8iteddug	408	22	and	and	CC
cord-306904-8iteddug	408	23	pathogenesis	pathogenesis	NN
cord-306904-8iteddug	408	24	being	be	VBG
cord-306904-8iteddug	408	25	involved	involve	VBN
cord-306904-8iteddug	408	26	in	in	IN
cord-306904-8iteddug	408	27	the	the	DT
cord-306904-8iteddug	408	28	coordination	coordination	NN
cord-306904-8iteddug	408	29	of	of	IN
cord-306904-8iteddug	408	30	several	several	JJ
cord-306904-8iteddug	408	31	important	important	JJ
cord-306904-8iteddug	408	32	 	 	_SP
cord-306904-8iteddug	408	33	Volume	volume	NN
cord-306904-8iteddug	408	34	2	2	CD
cord-306904-8iteddug	408	35	Issue	issue	NN
cord-306904-8iteddug	408	36	1	1	CD
cord-306904-8iteddug	409	1	Intrinsically	intrinsically	RB
cord-306904-8iteddug	409	2	Disordered	disordered	JJ
cord-306904-8iteddug	409	3	Proteins	protein	NNS
cord-306904-8iteddug	409	4	signaling	signal	VBG
cord-306904-8iteddug	409	5	events	event	NNS
cord-306904-8iteddug	409	6	in	in	IN
cord-306904-8iteddug	409	7	the	the	DT
cord-306904-8iteddug	409	8	cardiovascular	cardiovascular	JJ
cord-306904-8iteddug	409	9	and	and	CC
cord-306904-8iteddug	409	10	nervous	nervous	JJ
cord-306904-8iteddug	409	11	system	system	NN
cord-306904-8iteddug	409	12	.	.	.
cord-306904-8iteddug	410	1	The	the	DT
cord-306904-8iteddug	410	2	members	member	NNS
cord-306904-8iteddug	410	3	of	of	IN
cord-306904-8iteddug	410	4	the	the	DT
cord-306904-8iteddug	410	5	class	class	NN
cord-306904-8iteddug	410	6	III	iii	CD
cord-306904-8iteddug	410	7	Semaphorin	Semaphorin	NNP
cord-306904-8iteddug	410	8	(	(	-LRB-
cord-306904-8iteddug	410	9	Sema3	Sema3	NNP
cord-306904-8iteddug	410	10	)	)	-RRB-
cord-306904-8iteddug	410	11	family	family	NN
cord-306904-8iteddug	410	12	of	of	IN
cord-306904-8iteddug	410	13	axon	axon	NN
cord-306904-8iteddug	410	14	guidance	guidance	NN
cord-306904-8iteddug	410	15	molecules	molecule	NNS
cord-306904-8iteddug	410	16	are	be	VBP
cord-306904-8iteddug	410	17	among	among	IN
cord-306904-8iteddug	410	18	the	the	DT
cord-306904-8iteddug	410	19	ligands	ligand	NNS
cord-306904-8iteddug	410	20	neuropilins	neuropilin	NNS
cord-306904-8iteddug	410	21	(	(	-LRB-
cord-306904-8iteddug	410	22	Nrps	Nrps	NNP
cord-306904-8iteddug	410	23	)	)	-RRB-
cord-306904-8iteddug	410	24	.	.	.
cord-306904-8iteddug	411	1	Ligand	ligand	NN
cord-306904-8iteddug	411	2	binding	binding	NN
cord-306904-8iteddug	411	3	of	of	IN
cord-306904-8iteddug	411	4	Nrps	Nrps	NNP
cord-306904-8iteddug	411	5	is	be	VBZ
cord-306904-8iteddug	411	6	a	a	DT
cord-306904-8iteddug	411	7	subject	subject	NN
cord-306904-8iteddug	411	8	of	of	IN
cord-306904-8iteddug	411	9	the	the	DT
cord-306904-8iteddug	411	10	intensive	intensive	JJ
cord-306904-8iteddug	411	11	research	research	NN
cord-306904-8iteddug	411	12	due	due	IN
cord-306904-8iteddug	411	13	to	to	IN
cord-306904-8iteddug	411	14	the	the	DT
cord-306904-8iteddug	411	15	involvement	involvement	NN
cord-306904-8iteddug	411	16	of	of	IN
cord-306904-8iteddug	411	17	these	these	DT
cord-306904-8iteddug	411	18	transmembrane	transmembrane	JJ
cord-306904-8iteddug	411	19	receptors	receptor	NNS
cord-306904-8iteddug	411	20	in	in	IN
cord-306904-8iteddug	411	21	various	various	JJ
cord-306904-8iteddug	411	22	pathogenic	pathogenic	JJ
cord-306904-8iteddug	411	23	conditions	condition	NNS
cord-306904-8iteddug	411	24	.	.	.
cord-306904-8iteddug	412	1	It	-PRON-	PRP
cord-306904-8iteddug	412	2	has	have	VBZ
cord-306904-8iteddug	412	3	been	be	VBN
cord-306904-8iteddug	412	4	established	establish	VBN
cord-306904-8iteddug	412	5	that	that	IN
cord-306904-8iteddug	412	6	all	all	DT
cord-306904-8iteddug	412	7	known	know	VBN
cord-306904-8iteddug	412	8	Nrp	Nrp	NNP
cord-306904-8iteddug	412	9	ligands	ligand	NNS
cord-306904-8iteddug	412	10	require	require	VBP
cord-306904-8iteddug	412	11	a	a	DT
cord-306904-8iteddug	412	12	C	c	NN
cord-306904-8iteddug	412	13	-	-	HYPH
cord-306904-8iteddug	412	14	terminal	terminal	NN
cord-306904-8iteddug	412	15	arginine	arginine	NN
cord-306904-8iteddug	412	16	(	(	-LRB-
cord-306904-8iteddug	412	17	C	C	NNP
cord-306904-8iteddug	412	18	R	r	NN
cord-306904-8iteddug	412	19	)	)	-RRB-
cord-306904-8iteddug	412	20	for	for	IN
cord-306904-8iteddug	412	21	binding	bind	VBG
cord-306904-8iteddug	412	22	to	to	IN
cord-306904-8iteddug	412	23	a	a	DT
cord-306904-8iteddug	412	24	conserved	conserved	JJ
cord-306904-8iteddug	412	25	pocket	pocket	NN
cord-306904-8iteddug	412	26	in	in	IN
cord-306904-8iteddug	412	27	the	the	DT
cord-306904-8iteddug	412	28	Nrp	Nrp	NNP
cord-306904-8iteddug	412	29	b1	b1	NN
cord-306904-8iteddug	412	30	domain	domain	NN
cord-306904-8iteddug	412	31	.	.	.
cord-306904-8iteddug	413	1	[	[	-LRB-
cord-306904-8iteddug	413	2	144	144	CD
cord-306904-8iteddug	413	3	]	]	-RRB-
cord-306904-8iteddug	413	4	[	[	-LRB-
cord-306904-8iteddug	413	5	145	145	CD
cord-306904-8iteddug	413	6	]	]	-RRB-
cord-306904-8iteddug	413	7	[	[	-LRB-
cord-306904-8iteddug	413	8	146	146	CD
cord-306904-8iteddug	413	9	]	]	-RRB-
cord-306904-8iteddug	413	10	[	[	-LRB-
cord-306904-8iteddug	413	11	147	147	CD
cord-306904-8iteddug	413	12	]	]	-RRB-
cord-306904-8iteddug	414	1	To	to	TO
cord-306904-8iteddug	414	2	better	well	RBR
cord-306904-8iteddug	414	3	understand	understand	VB
cord-306904-8iteddug	414	4	the	the	DT
cord-306904-8iteddug	414	5	mechanism	mechanism	NN
cord-306904-8iteddug	414	6	of	of	IN
cord-306904-8iteddug	414	7	interaction	interaction	NN
cord-306904-8iteddug	414	8	between	between	IN
cord-306904-8iteddug	414	9	the	the	DT
cord-306904-8iteddug	414	10	Nrps	Nrps	NNP
cord-306904-8iteddug	414	11	and	and	CC
cord-306904-8iteddug	414	12	their	-PRON-	PRP$
cord-306904-8iteddug	414	13	ligands	ligand	NNS
cord-306904-8iteddug	414	14	and	and	CC
cord-306904-8iteddug	414	15	to	to	TO
cord-306904-8iteddug	414	16	understand	understand	VB
cord-306904-8iteddug	414	17	the	the	DT
cord-306904-8iteddug	414	18	role	role	NN
cord-306904-8iteddug	414	19	of	of	IN
cord-306904-8iteddug	414	20	residues	residue	NNS
cord-306904-8iteddug	414	21	upstream	upstream	RB
cord-306904-8iteddug	414	22	of	of	IN
cord-306904-8iteddug	414	23	the	the	DT
cord-306904-8iteddug	414	24	C	c	NN
cord-306904-8iteddug	414	25	R	R	NNP
cord-306904-8iteddug	414	26	,	,	,
cord-306904-8iteddug	414	27	Parker	Parker	NNP
cord-306904-8iteddug	414	28	et	et	NNP
cord-306904-8iteddug	414	29	al	al	NNP
cord-306904-8iteddug	414	30	.	.	.
cord-306904-8iteddug	415	1	synthesized	synthesize	VBD
cord-306904-8iteddug	415	2	a	a	DT
cord-306904-8iteddug	415	3	library	library	NN
cord-306904-8iteddug	415	4	of	of	IN
cord-306904-8iteddug	415	5	semaphorin-3	semaphorin-3	NNP
cord-306904-8iteddug	415	6	derived	derive	VBN
cord-306904-8iteddug	415	7	peptides	peptide	NNS
cord-306904-8iteddug	415	8	.	.	.
cord-306904-8iteddug	416	1	This	this	DT
cord-306904-8iteddug	416	2	study	study	NN
cord-306904-8iteddug	416	3	revealed	reveal	VBD
cord-306904-8iteddug	416	4	that	that	IN
cord-306904-8iteddug	416	5	the	the	DT
cord-306904-8iteddug	416	6	C-1	C-1	NNP
cord-306904-8iteddug	416	7	residue	residue	NN
cord-306904-8iteddug	416	8	(	(	-LRB-
cord-306904-8iteddug	416	9	i.e.	i.e.	FW
cord-306904-8iteddug	416	10	,	,	,
cord-306904-8iteddug	416	11	residue	residue	NN
cord-306904-8iteddug	416	12	preceding	precede	VBG
cord-306904-8iteddug	416	13	the	the	DT
cord-306904-8iteddug	416	14	C	C	NNP
cord-306904-8iteddug	416	15	R	r	NN
cord-306904-8iteddug	416	16	)	)	-RRB-
cord-306904-8iteddug	416	17	serves	serve	VBZ
cord-306904-8iteddug	416	18	the	the	DT
cord-306904-8iteddug	416	19	critical	critical	JJ
cord-306904-8iteddug	416	20	role	role	NN
cord-306904-8iteddug	416	21	of	of	IN
cord-306904-8iteddug	416	22	positioning	position	VBG
cord-306904-8iteddug	416	23	the	the	DT
cord-306904-8iteddug	416	24	C	c	NN
cord-306904-8iteddug	416	25	R	r	NN
cord-306904-8iteddug	416	26	and	and	CC
cord-306904-8iteddug	416	27	C-2	c-2	NN
cord-306904-8iteddug	416	28	residues	residue	NNS
cord-306904-8iteddug	416	29	to	to	TO
cord-306904-8iteddug	416	30	promote	promote	VB
cord-306904-8iteddug	416	31	concurrent	concurrent	JJ
cord-306904-8iteddug	416	32	Nrp	Nrp	NNP
cord-306904-8iteddug	416	33	binding	bind	VBG
cord-306904-8iteddug	416	34	.	.	.
cord-306904-8iteddug	417	1	143	143	CD
cord-306904-8iteddug	417	2	Bioinformatics	Bioinformatics	NNP
cord-306904-8iteddug	417	3	analysis	analysis	NN
cord-306904-8iteddug	417	4	revealed	reveal	VBD
cord-306904-8iteddug	417	5	that	that	IN
cord-306904-8iteddug	417	6	the	the	DT
cord-306904-8iteddug	417	7	analyzed	analyze	VBN
cord-306904-8iteddug	417	8	sequence	sequence	NN
cord-306904-8iteddug	417	9	(	(	-LRB-
cord-306904-8iteddug	417	10	WDQKKPRNRR	WDQKKPRNRR	NNP
cord-306904-8iteddug	417	11	)	)	-RRB-
cord-306904-8iteddug	417	12	is	be	VBZ
cord-306904-8iteddug	417	13	a	a	DT
cord-306904-8iteddug	417	14	part	part	NN
cord-306904-8iteddug	417	15	of	of	IN
cord-306904-8iteddug	417	16	long	long	RB
cord-306904-8iteddug	417	17	intrinsically	intrinsically	RB
cord-306904-8iteddug	417	18	disordered	disordered	JJ
cord-306904-8iteddug	417	19	tail	tail	NN
cord-306904-8iteddug	417	20	that	that	WDT
cord-306904-8iteddug	417	21	spans	span	VBZ
cord-306904-8iteddug	417	22	over	over	IN
cord-306904-8iteddug	417	23	the	the	DT
cord-306904-8iteddug	417	24	last	last	JJ
cord-306904-8iteddug	417	25	100	100	CD
cord-306904-8iteddug	417	26	residues	residue	NNS
cord-306904-8iteddug	417	27	of	of	IN
cord-306904-8iteddug	417	28	human	human	NN
cord-306904-8iteddug	417	29	semaphorin-3	semaphorin-3	NNP
cord-306904-8iteddug	417	30	(	(	-LRB-
cord-306904-8iteddug	417	31	Uni	Uni	NNP
cord-306904-8iteddug	417	32	-	-	HYPH
cord-306904-8iteddug	417	33	Prot	Prot	NNP
cord-306904-8iteddug	417	34	ID	ID	NNP
cord-306904-8iteddug	417	35	:	:	:
cord-306904-8iteddug	418	1	Q13275	Q13275	NNP
cord-306904-8iteddug	418	2	,	,	,
cord-306904-8iteddug	418	3	see	see	VB
cord-306904-8iteddug	418	4	Fig	Fig	NNP
cord-306904-8iteddug	418	5	.	.	.
cord-306904-8iteddug	418	6	9F	9f	NN
cord-306904-8iteddug	418	7	)	)	-RRB-
cord-306904-8iteddug	418	8	.	.	.
cord-306904-8iteddug	419	1	Malashkevich	Malashkevich	NNP
cord-306904-8iteddug	419	2	et	et	NNP
cord-306904-8iteddug	419	3	al	al	NNP
cord-306904-8iteddug	419	4	.	.	NNP
cord-306904-8iteddug	419	5	reported	report	VBD
cord-306904-8iteddug	419	6	the	the	DT
cord-306904-8iteddug	419	7	X	x	NN
cord-306904-8iteddug	419	8	-	-	NN
cord-306904-8iteddug	419	9	ray	ray	NN
cord-306904-8iteddug	419	10	crystal	crystal	NN
cord-306904-8iteddug	419	11	structure	structure	NN
cord-306904-8iteddug	419	12	of	of	IN
cord-306904-8iteddug	419	13	the	the	DT
cord-306904-8iteddug	419	14	unmodified	unmodified	JJ
cord-306904-8iteddug	419	15	3	3	CD
cord-306904-8iteddug	419	16	Glu	Glu	NNP
cord-306904-8iteddug	419	17	-	-	HYPH
cord-306904-8iteddug	419	18	OCN	OCN	NNP
cord-306904-8iteddug	419	19	form	form	NN
cord-306904-8iteddug	419	20	of	of	IN
cord-306904-8iteddug	419	21	bovine	bovine	JJ
cord-306904-8iteddug	419	22	osteocalcin	osteocalcin	NN
cord-306904-8iteddug	419	23	.	.	.
cord-306904-8iteddug	420	1	148	148	CD
cord-306904-8iteddug	421	1	This	this	DT
cord-306904-8iteddug	421	2	is	be	VBZ
cord-306904-8iteddug	421	3	an	an	DT
cord-306904-8iteddug	421	4	important	important	JJ
cord-306904-8iteddug	421	5	contribution	contribution	NN
cord-306904-8iteddug	421	6	since	since	IN
cord-306904-8iteddug	421	7	it	-PRON-	PRP
cord-306904-8iteddug	421	8	adds	add	VBZ
cord-306904-8iteddug	421	9	a	a	DT
cord-306904-8iteddug	421	10	crucial	crucial	JJ
cord-306904-8iteddug	421	11	structural	structural	JJ
cord-306904-8iteddug	421	12	information	information	NN
cord-306904-8iteddug	421	13	on	on	IN
cord-306904-8iteddug	421	14	osteocalcin	osteocalcin	NN
cord-306904-8iteddug	421	15	,	,	,
cord-306904-8iteddug	421	16	which	which	WDT
cord-306904-8iteddug	421	17	is	be	VBZ
cord-306904-8iteddug	421	18	a	a	DT
cord-306904-8iteddug	421	19	small	small	JJ
cord-306904-8iteddug	421	20	,	,	,
cord-306904-8iteddug	421	21	abundant	abundant	JJ
cord-306904-8iteddug	421	22	noncollagenous	noncollagenous	NNP
cord-306904-8iteddug	421	23	protein	protein	NN
cord-306904-8iteddug	421	24	synthesized	synthesize	VBN
cord-306904-8iteddug	421	25	by	by	IN
cord-306904-8iteddug	421	26	osteoblasts	osteoblast	NNS
cord-306904-8iteddug	421	27	,	,	,
cord-306904-8iteddug	421	28	and	and	CC
cord-306904-8iteddug	421	29	that	that	DT
cord-306904-8iteddug	421	30	typically	typically	RB
cord-306904-8iteddug	421	31	contains	contain	VBZ
cord-306904-8iteddug	421	32	3	3	CD
cord-306904-8iteddug	421	33	g	g	NN
cord-306904-8iteddug	421	34	-	-	HYPH
cord-306904-8iteddug	421	35	carboxyglutamic	carboxyglutamic	JJ
cord-306904-8iteddug	421	36	acid	acid	NN
cord-306904-8iteddug	421	37	(	(	-LRB-
cord-306904-8iteddug	421	38	3	3	CD
cord-306904-8iteddug	421	39	Gla	Gla	NNP
cord-306904-8iteddug	421	40	-	-	HYPH
cord-306904-8iteddug	421	41	OCN	OCN	NNP
cord-306904-8iteddug	421	42	)	)	-RRB-
cord-306904-8iteddug	421	43	residues	residue	NNS
cord-306904-8iteddug	421	44	generated	generate	VBN
cord-306904-8iteddug	421	45	posttranslationally	posttranslationally	RB
cord-306904-8iteddug	421	46	in	in	IN
cord-306904-8iteddug	421	47	a	a	DT
cord-306904-8iteddug	421	48	vitamin	vitamin	NN
cord-306904-8iteddug	421	49	K	k	NN
cord-306904-8iteddug	421	50	-	-	HYPH
cord-306904-8iteddug	421	51	dependent	dependent	JJ
cord-306904-8iteddug	421	52	process	process	NN
cord-306904-8iteddug	421	53	149,150	149,150	CD
cord-306904-8iteddug	421	54	by	by	IN
cord-306904-8iteddug	421	55	the	the	DT
cord-306904-8iteddug	421	56	vitamin	vitamin	NN
cord-306904-8iteddug	421	57	K	k	NN
cord-306904-8iteddug	421	58	-	-	HYPH
cord-306904-8iteddug	421	59	dependent	dependent	JJ
cord-306904-8iteddug	421	60	(	(	-LRB-
cord-306904-8iteddug	421	61	VKD	VKD	NNP
cord-306904-8iteddug	421	62	)	)	-RRB-
cord-306904-8iteddug	421	63	carboxylase	carboxylase	NN
cord-306904-8iteddug	421	64	.	.	.
cord-306904-8iteddug	422	1	151	151	CD
cord-306904-8iteddug	422	2	Earlier	early	RBR
cord-306904-8iteddug	422	3	,	,	,
cord-306904-8iteddug	422	4	based	base	VBN
cord-306904-8iteddug	422	5	on	on	IN
cord-306904-8iteddug	422	6	the	the	DT
cord-306904-8iteddug	422	7	circular	circular	JJ
cord-306904-8iteddug	422	8	dichroism	dichroism	NN
cord-306904-8iteddug	422	9	study	study	NN
cord-306904-8iteddug	422	10	it	-PRON-	PRP
cord-306904-8iteddug	422	11	has	have	VBZ
cord-306904-8iteddug	422	12	been	be	VBN
cord-306904-8iteddug	422	13	concluded	conclude	VBN
cord-306904-8iteddug	422	14	that	that	IN
cord-306904-8iteddug	422	15	in	in	IN
cord-306904-8iteddug	422	16	the	the	DT
cord-306904-8iteddug	422	17	presence	presence	NN
cord-306904-8iteddug	422	18	of	of	IN
cord-306904-8iteddug	422	19	Ca	Ca	NNP
cord-306904-8iteddug	422	20	2C	2C	NNP
cord-306904-8iteddug	422	21	,	,	,
cord-306904-8iteddug	422	22	the	the	DT
cord-306904-8iteddug	422	23	3	3	CD
cord-306904-8iteddug	422	24	Glu	Glu	NNP
cord-306904-8iteddug	422	25	-	-	HYPH
cord-306904-8iteddug	422	26	OCN	OCN	NNP
cord-306904-8iteddug	422	27	molecule	molecule	NN
cord-306904-8iteddug	422	28	contained	contain	VBD
cord-306904-8iteddug	422	29	significantly	significantly	RB
cord-306904-8iteddug	422	30	less	less	RBR
cord-306904-8iteddug	422	31	a	a	DT
cord-306904-8iteddug	422	32	-	-	HYPH
cord-306904-8iteddug	422	33	helical	helical	JJ
cord-306904-8iteddug	422	34	structure	structure	NN
cord-306904-8iteddug	422	35	than	than	IN
cord-306904-8iteddug	422	36	the	the	DT
cord-306904-8iteddug	422	37	3	3	CD
cord-306904-8iteddug	422	38	Gla	Gla	NNP
cord-306904-8iteddug	422	39	-	-	HYPH
cord-306904-8iteddug	422	40	OCN	OCN	NNP
cord-306904-8iteddug	422	41	form	form	NN
cord-306904-8iteddug	422	42	.	.	.
cord-306904-8iteddug	423	1	152	152	CD
cord-306904-8iteddug	424	1	Furthermore	furthermore	RB
cord-306904-8iteddug	424	2	,	,	,
cord-306904-8iteddug	424	3	it	-PRON-	PRP
cord-306904-8iteddug	424	4	was	be	VBD
cord-306904-8iteddug	424	5	shown	show	VBN
cord-306904-8iteddug	424	6	that	that	IN
cord-306904-8iteddug	424	7	Ca	Ca	NNP
cord-306904-8iteddug	424	8	2C	2c	VB
cord-306904-8iteddug	424	9	no	no	RB
cord-306904-8iteddug	424	10	longer	long	RBR
cord-306904-8iteddug	424	11	binds	bind	VBZ
cord-306904-8iteddug	424	12	to	to	IN
cord-306904-8iteddug	424	13	decarboxylated	decarboxylate	VBN
cord-306904-8iteddug	424	14	,	,	,
cord-306904-8iteddug	424	15	unmodified	unmodified	JJ
cord-306904-8iteddug	424	16	osteocalcin	osteocalcin	NN
cord-306904-8iteddug	424	17	153	153	CD
cord-306904-8iteddug	424	18	Malashkevich	Malashkevich	NNP
cord-306904-8iteddug	424	19	et	et	NNP
cord-306904-8iteddug	424	20	al	al	NNP
cord-306904-8iteddug	424	21	.	.	NNP
cord-306904-8iteddug	424	22	revealed	reveal	VBD
cord-306904-8iteddug	424	23	that	that	IN
cord-306904-8iteddug	424	24	the	the	DT
cord-306904-8iteddug	424	25	crystal	crystal	NN
cord-306904-8iteddug	424	26	structure	structure	NN
cord-306904-8iteddug	424	27	of	of	IN
cord-306904-8iteddug	424	28	the	the	DT
cord-306904-8iteddug	424	29	thermally	thermally	RB
cord-306904-8iteddug	424	30	decarboxylated	decarboxylate	VBN
cord-306904-8iteddug	424	31	bovine	bovine	JJ
cord-306904-8iteddug	424	32	osteocalcin	osteocalcin	NN
cord-306904-8iteddug	424	33	contained	contain	VBD
cord-306904-8iteddug	424	34	residues	residue	NNS
cord-306904-8iteddug	424	35	17	17	CD
cord-306904-8iteddug	424	36	-	-	SYM
cord-306904-8iteddug	424	37	47	47	CD
cord-306904-8iteddug	424	38	,	,	,
cord-306904-8iteddug	424	39	was	be	VBD
cord-306904-8iteddug	424	40	rather	rather	RB
cord-306904-8iteddug	424	41	similar	similar	JJ
cord-306904-8iteddug	424	42	to	to	IN
cord-306904-8iteddug	424	43	3	3	CD
cord-306904-8iteddug	424	44	Gla	Gla	NNP
cord-306904-8iteddug	424	45	Ca	Ca	NNP
cord-306904-8iteddug	424	46	2C	2c	NN
cord-306904-8iteddug	424	47	-OCN	-OCN	-RRB-
cord-306904-8iteddug	424	48	,	,	,
cord-306904-8iteddug	424	49	consisted	consist	VBD
cord-306904-8iteddug	424	50	of	of	IN
cord-306904-8iteddug	424	51	3	3	CD
cord-306904-8iteddug	424	52	a	a	DT
cord-306904-8iteddug	424	53	-	-	:
cord-306904-8iteddug	424	54	helices	helix	NNS
cord-306904-8iteddug	424	55	surrounding	surround	VBG
cord-306904-8iteddug	424	56	a	a	DT
cord-306904-8iteddug	424	57	hydrophobic	hydrophobic	JJ
cord-306904-8iteddug	424	58	core	core	NN
cord-306904-8iteddug	424	59	,	,	,
cord-306904-8iteddug	424	60	and	and	CC
cord-306904-8iteddug	424	61	contained	contain	VBD
cord-306904-8iteddug	424	62	C23-C29	c23-c29	NN
cord-306904-8iteddug	424	63	disulfide	disulfide	JJ
cord-306904-8iteddug	424	64	bond	bond	NN
cord-306904-8iteddug	424	65	between	between	IN
cord-306904-8iteddug	424	66	2	2	CD
cord-306904-8iteddug	424	67	of	of	IN
cord-306904-8iteddug	424	68	the	the	DT
cord-306904-8iteddug	424	69	helices	helix	NNS
cord-306904-8iteddug	424	70	but	but	CC
cord-306904-8iteddug	424	71	did	do	VBD
cord-306904-8iteddug	424	72	not	not	RB
cord-306904-8iteddug	424	73	contain	contain	VB
cord-306904-8iteddug	424	74	bound	bind	VBN
cord-306904-8iteddug	424	75	Ca	Ca	NNP
cord-306904-8iteddug	424	76	2C	2c	NN
cord-306904-8iteddug	424	77	.	.	.
cord-306904-8iteddug	425	1	148	148	CD
cord-306904-8iteddug	426	1	This	this	DT
cord-306904-8iteddug	426	2	is	be	VBZ
cord-306904-8iteddug	426	3	an	an	DT
cord-306904-8iteddug	426	4	interesting	interesting	JJ
cord-306904-8iteddug	426	5	finding	finding	NN
cord-306904-8iteddug	426	6	since	since	IN
cord-306904-8iteddug	426	7	earlier	early	JJR
cord-306904-8iteddug	426	8	work	work	NN
cord-306904-8iteddug	426	9	clearly	clearly	RB
cord-306904-8iteddug	426	10	showed	show	VBD
cord-306904-8iteddug	426	11	that	that	IN
cord-306904-8iteddug	426	12	in	in	IN
cord-306904-8iteddug	426	13	their	-PRON-	PRP$
cord-306904-8iteddug	426	14	apo	apo	NNP
cord-306904-8iteddug	426	15	-	-	HYPH
cord-306904-8iteddug	426	16	forms	form	NNS
cord-306904-8iteddug	426	17	,	,	,
cord-306904-8iteddug	426	18	modified	modified	JJ
cord-306904-8iteddug	426	19	and	and	CC
cord-306904-8iteddug	426	20	non	non	JJ
cord-306904-8iteddug	426	21	-	-	JJ
cord-306904-8iteddug	426	22	modified	modified	JJ
cord-306904-8iteddug	426	23	osteocalcin	osteocalcin	NN
cord-306904-8iteddug	426	24	from	from	IN
cord-306904-8iteddug	426	25	different	different	JJ
cord-306904-8iteddug	426	26	sources	source	NNS
cord-306904-8iteddug	426	27	are	be	VBP
cord-306904-8iteddug	426	28	mostly	mostly	RB
cord-306904-8iteddug	426	29	disordered	disordered	JJ
cord-306904-8iteddug	426	30	.	.	.
cord-306904-8iteddug	427	1	148	148	CD
cord-306904-8iteddug	428	1	The	the	DT
cord-306904-8iteddug	428	2	explanation	explanation	NN
cord-306904-8iteddug	428	3	for	for	IN
cord-306904-8iteddug	428	4	this	this	DT
cord-306904-8iteddug	428	5	apparent	apparent	JJ
cord-306904-8iteddug	428	6	contradiction	contradiction	NN
cord-306904-8iteddug	428	7	can	can	MD
cord-306904-8iteddug	428	8	be	be	VB
cord-306904-8iteddug	428	9	derived	derive	VBN
cord-306904-8iteddug	428	10	from	from	IN
cord-306904-8iteddug	428	11	the	the	DT
cord-306904-8iteddug	428	12	analysis	analysis	NN
cord-306904-8iteddug	428	13	of	of	IN
cord-306904-8iteddug	428	14	conditions	condition	NNS
cord-306904-8iteddug	428	15	used	use	VBN
cord-306904-8iteddug	428	16	for	for	IN
cord-306904-8iteddug	428	17	the	the	DT
cord-306904-8iteddug	428	18	3	3	CD
cord-306904-8iteddug	428	19	Glu	Glu	NNP
cord-306904-8iteddug	428	20	-	-	HYPH
cord-306904-8iteddug	428	21	OCN	OCN	NNP
cord-306904-8iteddug	428	22	crystallization	crystallization	NN
cord-306904-8iteddug	428	23	,	,	,
cord-306904-8iteddug	428	24	where	where	WRB
cord-306904-8iteddug	428	25	protein	protein	NN
cord-306904-8iteddug	428	26	in	in	IN
cord-306904-8iteddug	428	27	20	20	CD
cord-306904-8iteddug	428	28	mM	mm	CD
cord-306904-8iteddug	428	29	NaCl	nacl	NN
cord-306904-8iteddug	428	30	and	and	CC
cord-306904-8iteddug	428	31	10	10	CD
cord-306904-8iteddug	428	32	mM	mm	CD
cord-306904-8iteddug	428	33	CaCl	cacl	NN
cord-306904-8iteddug	428	34	2	2	CD
cord-306904-8iteddug	428	35	(	(	-LRB-
cord-306904-8iteddug	428	36	pH	pH	NNP
cord-306904-8iteddug	428	37	7.0	7.0	CD
cord-306904-8iteddug	428	38	)	)	-RRB-
cord-306904-8iteddug	428	39	was	be	VBD
cord-306904-8iteddug	428	40	mixed	mix	VBN
cord-306904-8iteddug	428	41	with	with	IN
cord-306904-8iteddug	428	42	the	the	DT
cord-306904-8iteddug	428	43	reservoir	reservoir	NN
cord-306904-8iteddug	428	44	solution	solution	NN
cord-306904-8iteddug	428	45	containing	contain	VBG
cord-306904-8iteddug	428	46	2.5	2.5	CD
cord-306904-8iteddug	428	47	M	M	NNP
cord-306904-8iteddug	428	48	ammonium	ammonium	NN
cord-306904-8iteddug	428	49	sulfate	sulfate	NN
cord-306904-8iteddug	428	50	and	and	CC
cord-306904-8iteddug	428	51	0.1	0.1	CD
cord-306904-8iteddug	428	52	M	M	NNP
cord-306904-8iteddug	428	53	Bis	Bis	NNP
cord-306904-8iteddug	428	54	-	-	HYPH
cord-306904-8iteddug	428	55	Tris	Tris	NNP
cord-306904-8iteddug	428	56	propane	propane	NN
cord-306904-8iteddug	428	57	(	(	-LRB-
cord-306904-8iteddug	428	58	pH	pH	NNP
cord-306904-8iteddug	428	59	7.0	7.0	CD
cord-306904-8iteddug	428	60	)	)	-RRB-
cord-306904-8iteddug	428	61	in	in	IN
cord-306904-8iteddug	428	62	1:1	1:1	CD
cord-306904-8iteddug	428	63	ratio	ratio	NN
cord-306904-8iteddug	428	64	.	.	.
cord-306904-8iteddug	429	1	148	148	CD
cord-306904-8iteddug	430	1	Therefore	therefore	RB
cord-306904-8iteddug	430	2	,	,	,
cord-306904-8iteddug	430	3	high	high	JJ
cord-306904-8iteddug	430	4	ionic	ionic	JJ
cord-306904-8iteddug	430	5	strength	strength	NN
cord-306904-8iteddug	430	6	solution	solution	NN
cord-306904-8iteddug	430	7	was	be	VBD
cord-306904-8iteddug	430	8	used	use	VBN
cord-306904-8iteddug	430	9	to	to	TO
cord-306904-8iteddug	430	10	partially	partially	RB
cord-306904-8iteddug	430	11	neutralize	neutralize	VB
cord-306904-8iteddug	430	12	the	the	DT
cord-306904-8iteddug	430	13	high	high	JJ
cord-306904-8iteddug	430	14	anionic	anionic	JJ
cord-306904-8iteddug	430	15	charge	charge	NN
cord-306904-8iteddug	430	16	in	in	IN
cord-306904-8iteddug	430	17	the	the	DT
cord-306904-8iteddug	430	18	helical	helical	JJ
cord-306904-8iteddug	430	19	regions	region	NNS
cord-306904-8iteddug	430	20	of	of	IN
cord-306904-8iteddug	430	21	osteocalcin	osteocalcin	NN
cord-306904-8iteddug	430	22	.	.	.
cord-306904-8iteddug	431	1	Although	although	IN
cord-306904-8iteddug	431	2	this	this	DT
cord-306904-8iteddug	431	3	approach	approach	NN
cord-306904-8iteddug	431	4	permitted	permit	VBD
cord-306904-8iteddug	431	5	better	well	JJR
cord-306904-8iteddug	431	6	realization	realization	NN
cord-306904-8iteddug	431	7	of	of	IN
cord-306904-8iteddug	431	8	the	the	DT
cord-306904-8iteddug	431	9	a	a	DT
cord-306904-8iteddug	431	10	-	-	HYPH
cord-306904-8iteddug	431	11	helix	helix	NN
cord-306904-8iteddug	431	12	-	-	HYPH
cord-306904-8iteddug	431	13	forming	form	VBG
cord-306904-8iteddug	431	14	potential	potential	NN
cord-306904-8iteddug	431	15	of	of	IN
cord-306904-8iteddug	431	16	the	the	DT
cord-306904-8iteddug	431	17	nonmodified	nonmodified	JJ
cord-306904-8iteddug	431	18	osteocalcin	osteocalcin	NN
cord-306904-8iteddug	431	19	,	,	,
cord-306904-8iteddug	431	20	the	the	DT
cord-306904-8iteddug	431	21	crystallization	crystallization	NN
cord-306904-8iteddug	431	22	conditions	condition	NNS
cord-306904-8iteddug	431	23	are	be	VBP
cord-306904-8iteddug	431	24	clearly	clearly	RB
cord-306904-8iteddug	431	25	non	non	JJ
cord-306904-8iteddug	431	26	-	-	JJ
cord-306904-8iteddug	431	27	physiological	physiological	JJ
cord-306904-8iteddug	431	28	.	.	.
cord-306904-8iteddug	432	1	Sasi	Sasi	NNP
cord-306904-8iteddug	432	2	et	et	NNP
cord-306904-8iteddug	432	3	al	al	NNP
cord-306904-8iteddug	432	4	.	.	NNP
cord-306904-8iteddug	432	5	investigated	investigate	VBD
cord-306904-8iteddug	432	6	the	the	DT
cord-306904-8iteddug	432	7	peculiarities	peculiarity	NNS
cord-306904-8iteddug	432	8	of	of	IN
cord-306904-8iteddug	432	9	the	the	DT
cord-306904-8iteddug	432	10	regulation	regulation	NN
cord-306904-8iteddug	432	11	of	of	IN
cord-306904-8iteddug	432	12	expression	expression	NN
cord-306904-8iteddug	432	13	of	of	IN
cord-306904-8iteddug	432	14	the	the	DT
cord-306904-8iteddug	432	15	inducible	inducible	JJ
cord-306904-8iteddug	432	16	heat	heat	NN
cord-306904-8iteddug	432	17	shock	shock	NN
cord-306904-8iteddug	432	18	protein	protein	NN
cord-306904-8iteddug	432	19	HSPA1A	hspa1a	IN
cord-306904-8iteddug	432	20	at	at	IN
cord-306904-8iteddug	432	21	the	the	DT
cord-306904-8iteddug	432	22	transcription	transcription	NN
cord-306904-8iteddug	432	23	level	level	NN
cord-306904-8iteddug	432	24	by	by	IN
cord-306904-8iteddug	432	25	several	several	JJ
cord-306904-8iteddug	432	26	transcription	transcription	NN
cord-306904-8iteddug	432	27	factors	factor	NNS
cord-306904-8iteddug	432	28	.	.	.
cord-306904-8iteddug	433	1	154	154	CD
cord-306904-8iteddug	433	2	HSPA1A	hspa1a	RB
cord-306904-8iteddug	433	3	,	,	,
cord-306904-8iteddug	433	4	together	together	RB
cord-306904-8iteddug	433	5	with	with	IN
cord-306904-8iteddug	433	6	HSPA1B	HSPA1B	NNP
cord-306904-8iteddug	433	7	are	be	VBP
cord-306904-8iteddug	433	8	the	the	DT
cord-306904-8iteddug	433	9	members	member	NNS
cord-306904-8iteddug	433	10	of	of	IN
cord-306904-8iteddug	433	11	the	the	DT
cord-306904-8iteddug	433	12	human	human	JJ
cord-306904-8iteddug	433	13	inducible	inducible	JJ
cord-306904-8iteddug	433	14	heat	heat	NN
cord-306904-8iteddug	433	15	shock	shock	NN
cord-306904-8iteddug	433	16	protein	protein	NN
cord-306904-8iteddug	433	17	family	family	NN
cord-306904-8iteddug	433	18	(	(	-LRB-
cord-306904-8iteddug	433	19	Hsp70	Hsp70	NNP
cord-306904-8iteddug	433	20	)	)	-RRB-
cord-306904-8iteddug	433	21	,	,	,
cord-306904-8iteddug	433	22	altered	alter	VBN
cord-306904-8iteddug	433	23	expression	expression	NN
cord-306904-8iteddug	433	24	of	of	IN
cord-306904-8iteddug	433	25	which	which	WDT
cord-306904-8iteddug	433	26	has	have	VBZ
cord-306904-8iteddug	433	27	been	be	VBN
cord-306904-8iteddug	433	28	attributed	attribute	VBN
cord-306904-8iteddug	433	29	to	to	IN
cord-306904-8iteddug	433	30	the	the	DT
cord-306904-8iteddug	433	31	pathogenesis	pathogenesis	NN
cord-306904-8iteddug	433	32	of	of	IN
cord-306904-8iteddug	433	33	various	various	JJ
cord-306904-8iteddug	433	34	diseases	disease	NNS
cord-306904-8iteddug	433	35	,	,	,
cord-306904-8iteddug	433	36	such	such	JJ
cord-306904-8iteddug	433	37	as	as	IN
cord-306904-8iteddug	433	38	cancer	cancer	NN
cord-306904-8iteddug	433	39	,	,	,
cord-306904-8iteddug	433	40	cardiovascular	cardiovascular	JJ
cord-306904-8iteddug	433	41	diseases	disease	NNS
cord-306904-8iteddug	433	42	,	,	,
cord-306904-8iteddug	433	43	and	and	CC
cord-306904-8iteddug	433	44	neurodegenerative	neurodegenerative	JJ
cord-306904-8iteddug	433	45	disorders	disorder	NNS
cord-306904-8iteddug	433	46	.	.	.
cord-306904-8iteddug	434	1	[	[	-LRB-
cord-306904-8iteddug	434	2	155	155	CD
cord-306904-8iteddug	434	3	]	]	-RRB-
cord-306904-8iteddug	434	4	[	[	-LRB-
cord-306904-8iteddug	434	5	156	156	CD
cord-306904-8iteddug	434	6	]	]	-RRB-
cord-306904-8iteddug	434	7	[	[	-LRB-
cord-306904-8iteddug	434	8	157	157	CD
cord-306904-8iteddug	434	9	]	]	-RRB-
cord-306904-8iteddug	434	10	[	[	-LRB-
cord-306904-8iteddug	434	11	158	158	CD
cord-306904-8iteddug	434	12	]	]	-RRB-
cord-306904-8iteddug	435	1	It	-PRON-	PRP
cord-306904-8iteddug	435	2	is	be	VBZ
cord-306904-8iteddug	435	3	known	know	VBN
cord-306904-8iteddug	435	4	that	that	IN
cord-306904-8iteddug	435	5	the	the	DT
cord-306904-8iteddug	435	6	heat	heat	NN
cord-306904-8iteddug	435	7	shock	shock	NN
cord-306904-8iteddug	435	8	response	response	NN
cord-306904-8iteddug	435	9	-	-	HYPH
cord-306904-8iteddug	435	10	related	relate	VBN
cord-306904-8iteddug	435	11	proteins	protein	NNS
cord-306904-8iteddug	435	12	(	(	-LRB-
cord-306904-8iteddug	435	13	including	include	VBG
cord-306904-8iteddug	435	14	Hsp70	Hsp70	NNP
cord-306904-8iteddug	435	15	)	)	-RRB-
cord-306904-8iteddug	435	16	can	can	MD
cord-306904-8iteddug	435	17	be	be	VB
cord-306904-8iteddug	435	18	expressed	express	VBN
cord-306904-8iteddug	435	19	during	during	IN
cord-306904-8iteddug	435	20	normal	normal	JJ
cord-306904-8iteddug	435	21	conditions	condition	NNS
cord-306904-8iteddug	435	22	(	(	-LRB-
cord-306904-8iteddug	435	23	e.g.	e.g.	RB
cord-306904-8iteddug	435	24	,	,	,
cord-306904-8iteddug	435	25	during	during	IN
cord-306904-8iteddug	435	26	the	the	DT
cord-306904-8iteddug	435	27	cell	cell	NN
cord-306904-8iteddug	435	28	growth	growth	NN
cord-306904-8iteddug	435	29	and	and	CC
cord-306904-8iteddug	435	30	development	development	NN
cord-306904-8iteddug	435	31	)	)	-RRB-
cord-306904-8iteddug	435	32	or	or	CC
cord-306904-8iteddug	435	33	can	can	MD
cord-306904-8iteddug	435	34	be	be	VB
cord-306904-8iteddug	435	35	induced	induce	VBN
cord-306904-8iteddug	435	36	by	by	IN
cord-306904-8iteddug	435	37	various	various	JJ
cord-306904-8iteddug	435	38	pathological	pathological	JJ
cord-306904-8iteddug	435	39	conditions	condition	NNS
cord-306904-8iteddug	435	40	,	,	,
cord-306904-8iteddug	435	41	such	such	JJ
cord-306904-8iteddug	435	42	as	as	IN
cord-306904-8iteddug	435	43	infection	infection	NN
cord-306904-8iteddug	435	44	,	,	,
cord-306904-8iteddug	435	45	inflammation	inflammation	NN
cord-306904-8iteddug	435	46	,	,	,
cord-306904-8iteddug	435	47	and	and	CC
cord-306904-8iteddug	435	48	protein	protein	NN
cord-306904-8iteddug	435	49	conformation	conformation	NN
cord-306904-8iteddug	435	50	diseases	disease	NNS
cord-306904-8iteddug	435	51	.	.	.
cord-306904-8iteddug	436	1	Sasi	Sasi	NNP
cord-306904-8iteddug	436	2	et	et	FW
cord-306904-8iteddug	436	3	al	al	NNP
cord-306904-8iteddug	436	4	.	.	.
cord-306904-8iteddug	437	1	show	show	VB
cord-306904-8iteddug	437	2	that	that	IN
cord-306904-8iteddug	437	3	transcription	transcription	NN
cord-306904-8iteddug	437	4	factors	factor	NNS
cord-306904-8iteddug	438	1	HSF-1	HSF-1	NNP
cord-306904-8iteddug	438	2	,	,	,
cord-306904-8iteddug	438	3	CREB	CREB	NNP
cord-306904-8iteddug	438	4	,	,	,
cord-306904-8iteddug	438	5	NF	NF	NNP
cord-306904-8iteddug	438	6	-	-	HYPH
cord-306904-8iteddug	438	7	Y	Y	NNP
cord-306904-8iteddug	438	8	,	,	,
cord-306904-8iteddug	438	9	and	and	CC
cord-306904-8iteddug	438	10	NF	NF	NNP
cord-306904-8iteddug	438	11	-	-	HYPH
cord-306904-8iteddug	438	12	kB	kB	NNP
cord-306904-8iteddug	438	13	synergistically	synergistically	RB
cord-306904-8iteddug	438	14	regulate	regulate	VBP
cord-306904-8iteddug	438	15	expression	expression	NN
cord-306904-8iteddug	438	16	of	of	IN
cord-306904-8iteddug	438	17	the	the	DT
cord-306904-8iteddug	438	18	heat	heat	NN
cord-306904-8iteddug	438	19	-	-	HYPH
cord-306904-8iteddug	438	20	shock	shock	NN
cord-306904-8iteddug	438	21	-	-	HYPH
cord-306904-8iteddug	438	22	induced	induce	VBN
cord-306904-8iteddug	438	23	gene	gene	NN
cord-306904-8iteddug	438	24	Hspa1a	hspa1a	NN
cord-306904-8iteddug	438	25	.	.	.
cord-306904-8iteddug	439	1	154	154	CD
cord-306904-8iteddug	440	1	The	the	DT
cord-306904-8iteddug	440	2	initiation	initiation	NN
cord-306904-8iteddug	440	3	of	of	IN
cord-306904-8iteddug	440	4	the	the	DT
cord-306904-8iteddug	440	5	heat	heat	NN
cord-306904-8iteddug	440	6	shock	shock	NN
cord-306904-8iteddug	440	7	response	response	NN
cord-306904-8iteddug	440	8	is	be	VBZ
cord-306904-8iteddug	440	9	manifested	manifest	VBN
cord-306904-8iteddug	440	10	by	by	IN
cord-306904-8iteddug	440	11	the	the	DT
cord-306904-8iteddug	440	12	activation	activation	NN
cord-306904-8iteddug	440	13	of	of	IN
cord-306904-8iteddug	440	14	the	the	DT
cord-306904-8iteddug	440	15	heat	heat	NN
cord-306904-8iteddug	440	16	shock	shock	NN
cord-306904-8iteddug	440	17	transcription	transcription	NN
cord-306904-8iteddug	440	18	factors	factor	NNS
cord-306904-8iteddug	440	19	(	(	-LRB-
cord-306904-8iteddug	440	20	HSFs	HSFs	NNP
cord-306904-8iteddug	440	21	)	)	-RRB-
cord-306904-8iteddug	440	22	,	,	,
cord-306904-8iteddug	440	23	a	a	DT
cord-306904-8iteddug	440	24	family	family	NN
cord-306904-8iteddug	440	25	of	of	IN
cord-306904-8iteddug	440	26	related	related	JJ
cord-306904-8iteddug	440	27	transcription	transcription	NN
cord-306904-8iteddug	440	28	factors	factor	NNS
cord-306904-8iteddug	440	29	which	which	WDT
cord-306904-8iteddug	440	30	,	,	,
cord-306904-8iteddug	440	31	in	in	IN
cord-306904-8iteddug	440	32	mammals	mammal	NNS
cord-306904-8iteddug	440	33	,	,	,
cord-306904-8iteddug	440	34	is	be	VBZ
cord-306904-8iteddug	440	35	composed	compose	VBN
cord-306904-8iteddug	440	36	of	of	IN
cord-306904-8iteddug	440	37	HSF-1	HSF-1	NNP
cord-306904-8iteddug	440	38	,	,	,
cord-306904-8iteddug	440	39	-2	-2	NNP
cord-306904-8iteddug	440	40	,	,	,
cord-306904-8iteddug	440	41	-3	-3	NNP
cord-306904-8iteddug	440	42	,	,	,
cord-306904-8iteddug	440	43	-4	-4	NNP
cord-306904-8iteddug	440	44	,	,	,
cord-306904-8iteddug	440	45	-5	-5	NNP
cord-306904-8iteddug	440	46	,	,	,
cord-306904-8iteddug	440	47	-Y	-Y	.
cord-306904-8iteddug	441	1	and	and	CC
cord-306904-8iteddug	441	2	-X.	-x.	CD
cord-306904-8iteddug	441	3	159	159	CD
cord-306904-8iteddug	441	4	cAMP	camp	NN
cord-306904-8iteddug	441	5	response	response	NN
cord-306904-8iteddug	441	6	element	element	NN
cord-306904-8iteddug	441	7	binding	bind	VBG
cord-306904-8iteddug	441	8	protein	protein	NN
cord-306904-8iteddug	441	9	(	(	-LRB-
cord-306904-8iteddug	441	10	CREB	CREB	NNP
cord-306904-8iteddug	441	11	)	)	-RRB-
cord-306904-8iteddug	441	12	is	be	VBZ
cord-306904-8iteddug	441	13	the	the	DT
cord-306904-8iteddug	441	14	cAMP	camp	NN
cord-306904-8iteddug	441	15	-	-	HYPH
cord-306904-8iteddug	441	16	regulated	regulate	VBN
cord-306904-8iteddug	441	17	transcription	transcription	NN
cord-306904-8iteddug	441	18	factor	factor	NN
cord-306904-8iteddug	441	19	that	that	WDT
cord-306904-8iteddug	441	20	has	have	VBZ
cord-306904-8iteddug	441	21	been	be	VBN
cord-306904-8iteddug	441	22	shown	show	VBN
cord-306904-8iteddug	441	23	to	to	TO
cord-306904-8iteddug	441	24	stimulate	stimulate	VB
cord-306904-8iteddug	441	25	target	target	NN
cord-306904-8iteddug	441	26	gene	gene	NN
cord-306904-8iteddug	441	27	expression	expression	NN
cord-306904-8iteddug	441	28	often	often	RB
cord-306904-8iteddug	441	29	via	via	IN
cord-306904-8iteddug	441	30	the	the	DT
cord-306904-8iteddug	441	31	associating	associating	NN
cord-306904-8iteddug	441	32	with	with	IN
cord-306904-8iteddug	441	33	the	the	DT
cord-306904-8iteddug	441	34	coactivator	coactivator	NN
cord-306904-8iteddug	441	35	paralogs	paralogs	NNP
cord-306904-8iteddug	441	36	P300	P300	NNP
cord-306904-8iteddug	441	37	and	and	CC
cord-306904-8iteddug	441	38	CREB	CREB	NNP
cord-306904-8iteddug	441	39	binding	bind	VBG
cord-306904-8iteddug	441	40	protein	protein	NN
cord-306904-8iteddug	441	41	(	(	-LRB-
cord-306904-8iteddug	441	42	CBP	CBP	NNP
cord-306904-8iteddug	441	43	)	)	-RRB-
cord-306904-8iteddug	441	44	.	.	.
cord-306904-8iteddug	442	1	[	[	-LRB-
cord-306904-8iteddug	442	2	160	160	CD
cord-306904-8iteddug	442	3	]	]	-RRB-
cord-306904-8iteddug	442	4	[	[	-LRB-
cord-306904-8iteddug	442	5	161	161	CD
cord-306904-8iteddug	442	6	]	]	-RRB-
cord-306904-8iteddug	442	7	[	[	-LRB-
cord-306904-8iteddug	442	8	162	162	CD
cord-306904-8iteddug	442	9	]	]	-RRB-
cord-306904-8iteddug	442	10	Complex	complex	JJ
cord-306904-8iteddug	442	11	formation	formation	NN
cord-306904-8iteddug	442	12	between	between	IN
cord-306904-8iteddug	442	13	CREB	CREB	NNP
cord-306904-8iteddug	442	14	and	and	CC
cord-306904-8iteddug	442	15	CBP	CBP	NNP
cord-306904-8iteddug	442	16	/	/	SYM
cord-306904-8iteddug	442	17	P300	P300	NNP
cord-306904-8iteddug	442	18	requires	require	VBZ
cord-306904-8iteddug	442	19	protein	protein	NN
cord-306904-8iteddug	442	20	kinase	kinase	VBZ
cord-306904-8iteddug	442	21	A	A	NNP
cord-306904-8iteddug	442	22	(	(	-LRB-
cord-306904-8iteddug	442	23	PKA)-mediated	pka)-mediated	JJ
cord-306904-8iteddug	442	24	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	442	25	of	of	IN
cord-306904-8iteddug	442	26	CREB	CREB	NNP
cord-306904-8iteddug	442	27	at	at	IN
cord-306904-8iteddug	442	28	Ser-133	Ser-133	NNP
cord-306904-8iteddug	442	29	.	.	.
cord-306904-8iteddug	443	1	160	160	CD
cord-306904-8iteddug	444	1	The	the	DT
cord-306904-8iteddug	444	2	nuclear	nuclear	JJ
cord-306904-8iteddug	444	3	transcription	transcription	NN
cord-306904-8iteddug	444	4	factor	factor	NN
cord-306904-8iteddug	444	5	Y	Y	NNP
cord-306904-8iteddug	444	6	(	(	-LRB-
cord-306904-8iteddug	444	7	NF	NF	NNP
cord-306904-8iteddug	444	8	-	-	HYPH
cord-306904-8iteddug	444	9	Y	Y	NNP
cord-306904-8iteddug	444	10	)	)	-RRB-
cord-306904-8iteddug	444	11	is	be	VBZ
cord-306904-8iteddug	444	12	a	a	DT
cord-306904-8iteddug	444	13	sequence	sequence	NN
cord-306904-8iteddug	444	14	-	-	HYPH
cord-306904-8iteddug	444	15	specific	specific	JJ
cord-306904-8iteddug	444	16	DNA	dna	NN
cord-306904-8iteddug	444	17	-	-	HYPH
cord-306904-8iteddug	444	18	binding	bind	VBG
cord-306904-8iteddug	444	19	protein	protein	NN
cord-306904-8iteddug	444	20	that	that	WDT
cord-306904-8iteddug	444	21	recognizes	recognize	VBZ
cord-306904-8iteddug	444	22	the	the	DT
cord-306904-8iteddug	444	23	Y	Y	NNP
cord-306904-8iteddug	444	24	box	box	NN
cord-306904-8iteddug	444	25	,	,	,
cord-306904-8iteddug	444	26	which	which	WDT
cord-306904-8iteddug	444	27	is	be	VBZ
cord-306904-8iteddug	444	28	a	a	DT
cord-306904-8iteddug	444	29	promoter	promoter	NN
cord-306904-8iteddug	444	30	element	element	NN
cord-306904-8iteddug	444	31	common	common	JJ
cord-306904-8iteddug	444	32	to	to	IN
cord-306904-8iteddug	444	33	all	all	DT
cord-306904-8iteddug	444	34	major	major	JJ
cord-306904-8iteddug	444	35	histocompatibility	histocompatibility	NN
cord-306904-8iteddug	444	36	complex	complex	JJ
cord-306904-8iteddug	444	37	class	class	NN
cord-306904-8iteddug	444	38	II	ii	CD
cord-306904-8iteddug	444	39	genes	gene	NNS
cord-306904-8iteddug	444	40	.	.	.
cord-306904-8iteddug	445	1	163	163	CD
cord-306904-8iteddug	446	1	Also	also	RB
cord-306904-8iteddug	446	2	,	,	,
cord-306904-8iteddug	446	3	NF	NF	NNP
cord-306904-8iteddug	446	4	-	-	HYPH
cord-306904-8iteddug	446	5	Y	Y	NNP
cord-306904-8iteddug	446	6	is	be	VBZ
cord-306904-8iteddug	446	7	known	know	VBN
cord-306904-8iteddug	446	8	to	to	TO
cord-306904-8iteddug	446	9	interact	interact	VB
cord-306904-8iteddug	446	10	with	with	IN
cord-306904-8iteddug	446	11	a	a	DT
cord-306904-8iteddug	446	12	CCAAT	CCAAT	NNP
cord-306904-8iteddug	446	13	box	box	NN
cord-306904-8iteddug	446	14	,	,	,
cord-306904-8iteddug	446	15	which	which	WDT
cord-306904-8iteddug	446	16	is	be	VBZ
cord-306904-8iteddug	446	17	one	one	CD
cord-306904-8iteddug	446	18	of	of	IN
cord-306904-8iteddug	446	19	the	the	DT
cord-306904-8iteddug	446	20	most	most	RBS
cord-306904-8iteddug	446	21	common	common	JJ
cord-306904-8iteddug	446	22	elements	element	NNS
cord-306904-8iteddug	446	23	in	in	IN
cord-306904-8iteddug	446	24	eukaryotic	eukaryotic	JJ
cord-306904-8iteddug	446	25	promoters	promoter	NNS
cord-306904-8iteddug	446	26	,	,	,
cord-306904-8iteddug	446	27	found	find	VBN
cord-306904-8iteddug	446	28	in	in	IN
cord-306904-8iteddug	446	29	the	the	DT
cord-306904-8iteddug	446	30	forward	forward	NN
cord-306904-8iteddug	446	31	or	or	CC
cord-306904-8iteddug	446	32	reverse	reverse	VB
cord-306904-8iteddug	446	33	orientation	orientation	NN
cord-306904-8iteddug	446	34	.	.	.
cord-306904-8iteddug	447	1	164	164	CD
cord-306904-8iteddug	448	1	Furthermore	furthermore	RB
cord-306904-8iteddug	448	2	,	,	,
cord-306904-8iteddug	448	3	NF	NF	NNP
cord-306904-8iteddug	448	4	-	-	HYPH
cord-306904-8iteddug	448	5	Y	Y	NNP
cord-306904-8iteddug	448	6	has	have	VBZ
cord-306904-8iteddug	448	7	been	be	VBN
cord-306904-8iteddug	448	8	reported	report	VBN
cord-306904-8iteddug	448	9	to	to	TO
cord-306904-8iteddug	448	10	play	play	VB
cord-306904-8iteddug	448	11	a	a	DT
cord-306904-8iteddug	448	12	key	key	JJ
cord-306904-8iteddug	448	13	role	role	NN
cord-306904-8iteddug	448	14	in	in	IN
cord-306904-8iteddug	448	15	the	the	DT
cord-306904-8iteddug	448	16	basal	basal	JJ
cord-306904-8iteddug	448	17	expression	expression	NN
cord-306904-8iteddug	448	18	of	of	IN
cord-306904-8iteddug	448	19	many	many	JJ
cord-306904-8iteddug	448	20	Hsps	Hsps	NNP
cord-306904-8iteddug	448	21	through	through	IN
cord-306904-8iteddug	448	22	this	this	DT
cord-306904-8iteddug	448	23	CCAAT	CCAAT	NNP
cord-306904-8iteddug	448	24	box	box	NN
cord-306904-8iteddug	448	25	.	.	.
cord-306904-8iteddug	449	1	165	165	CD
cord-306904-8iteddug	449	2	,	,	,
cord-306904-8iteddug	449	3	166	166	CD
cord-306904-8iteddug	449	4	NF	NF	NNP
cord-306904-8iteddug	449	5	-	-	HYPH
cord-306904-8iteddug	449	6	Y	Y	NNP
cord-306904-8iteddug	449	7	is	be	VBZ
cord-306904-8iteddug	449	8	heterotrimeric	heterotrimeric	JJ
cord-306904-8iteddug	449	9	transcription	transcription	NN
cord-306904-8iteddug	449	10	factor	factor	NN
cord-306904-8iteddug	449	11	composed	compose	VBN
cord-306904-8iteddug	449	12	of	of	IN
cord-306904-8iteddug	449	13	3	3	CD
cord-306904-8iteddug	449	14	components	component	NNS
cord-306904-8iteddug	449	15	,	,	,
cord-306904-8iteddug	449	16	NF	NF	NNP
cord-306904-8iteddug	449	17	-	-	HYPH
cord-306904-8iteddug	449	18	YA	YA	NNP
cord-306904-8iteddug	449	19	(	(	-LRB-
cord-306904-8iteddug	449	20	subunit	subunit	NN
cord-306904-8iteddug	449	21	a	a	DT
cord-306904-8iteddug	449	22	,	,	,
cord-306904-8iteddug	449	23	Uni	Uni	NNP
cord-306904-8iteddug	449	24	-	-	HYPH
cord-306904-8iteddug	449	25	Prot	Prot	NNP
cord-306904-8iteddug	449	26	ID	ID	NNP
cord-306904-8iteddug	449	27	:	:	:
cord-306904-8iteddug	449	28	P23511	P23511	NNP
cord-306904-8iteddug	449	29	)	)	-RRB-
cord-306904-8iteddug	449	30	,	,	,
cord-306904-8iteddug	449	31	NF	NF	NNP
cord-306904-8iteddug	449	32	-	-	HYPH
cord-306904-8iteddug	449	33	YB	YB	NNP
cord-306904-8iteddug	449	34	(	(	-LRB-
cord-306904-8iteddug	449	35	subunit	subunit	NN
cord-306904-8iteddug	449	36	b	b	NN
cord-306904-8iteddug	449	37	,	,	,
cord-306904-8iteddug	449	38	UniProt	UniProt	NNP
cord-306904-8iteddug	449	39	ID	ID	NNP
cord-306904-8iteddug	449	40	:	:	:
cord-306904-8iteddug	449	41	P25208	P25208	NNP
cord-306904-8iteddug	449	42	)	)	-RRB-
cord-306904-8iteddug	449	43	,	,	,
cord-306904-8iteddug	449	44	and	and	CC
cord-306904-8iteddug	449	45	NF	NF	NNP
cord-306904-8iteddug	449	46	-	-	HYPH
cord-306904-8iteddug	449	47	YC	YC	NNP
cord-306904-8iteddug	449	48	(	(	-LRB-
cord-306904-8iteddug	449	49	subunit	subunit	NN
cord-306904-8iteddug	449	50	g	g	NN
cord-306904-8iteddug	449	51	,	,	,
cord-306904-8iteddug	449	52	UniProt	UniProt	NNP
cord-306904-8iteddug	449	53	ID	ID	NNP
cord-306904-8iteddug	449	54	:	:	:
cord-306904-8iteddug	449	55	Q13952	Q13952	NNP
cord-306904-8iteddug	449	56	)	)	-RRB-
cord-306904-8iteddug	449	57	,	,	,
cord-306904-8iteddug	449	58	where	where	WRB
cord-306904-8iteddug	449	59	the	the	DT
cord-306904-8iteddug	449	60	dimerization	dimerization	NN
cord-306904-8iteddug	449	61	of	of	IN
cord-306904-8iteddug	449	62	NF	NF	NNP
cord-306904-8iteddug	449	63	-	-	HYPH
cord-306904-8iteddug	449	64	YB	YB	NNP
cord-306904-8iteddug	449	65	and	and	CC
cord-306904-8iteddug	449	66	NF	NF	NNP
cord-306904-8iteddug	449	67	-	-	HYPH
cord-306904-8iteddug	449	68	YC	YC	NNP
cord-306904-8iteddug	449	69	is	be	VBZ
cord-306904-8iteddug	449	70	a	a	DT
cord-306904-8iteddug	449	71	prerequisite	prerequisite	NN
cord-306904-8iteddug	449	72	for	for	IN
cord-306904-8iteddug	449	73	the	the	DT
cord-306904-8iteddug	449	74	NF	NF	NNP
cord-306904-8iteddug	449	75	-	-	HYPH
cord-306904-8iteddug	449	76	YA	YA	NNP
cord-306904-8iteddug	449	77	association	association	NN
cord-306904-8iteddug	449	78	and	and	CC
cord-306904-8iteddug	449	79	DNA	DNA	NNP
cord-306904-8iteddug	449	80	binding	binding	NN
cord-306904-8iteddug	449	81	.	.	.
cord-306904-8iteddug	450	1	167	167	CD
cord-306904-8iteddug	451	1	Finally	finally	RB
cord-306904-8iteddug	451	2	,	,	,
cord-306904-8iteddug	451	3	the	the	DT
cord-306904-8iteddug	451	4	transcription	transcription	NN
cord-306904-8iteddug	451	5	factor	factor	NN
cord-306904-8iteddug	451	6	nuclear	nuclear	JJ
cord-306904-8iteddug	451	7	factor	factor	NN
cord-306904-8iteddug	451	8	-	-	HYPH
cord-306904-8iteddug	451	9	kappa	kappa	NN
cord-306904-8iteddug	451	10	B	b	NN
cord-306904-8iteddug	451	11	(	(	-LRB-
cord-306904-8iteddug	451	12	NF	NF	NNP
cord-306904-8iteddug	451	13	-	-	HYPH
cord-306904-8iteddug	451	14	kB	kB	NNP
cord-306904-8iteddug	451	15	;	;	:
cord-306904-8iteddug	451	16	UniProt	UniProt	NNP
cord-306904-8iteddug	451	17	ID	ID	NNP
cord-306904-8iteddug	451	18	:	:	:
cord-306904-8iteddug	451	19	19838	19838	CD
cord-306904-8iteddug	451	20	)	)	-RRB-
cord-306904-8iteddug	451	21	is	be	VBZ
cord-306904-8iteddug	451	22	a	a	DT
cord-306904-8iteddug	451	23	key	key	JJ
cord-306904-8iteddug	451	24	player	player	NN
cord-306904-8iteddug	451	25	in	in	IN
cord-306904-8iteddug	451	26	an	an	DT
cord-306904-8iteddug	451	27	intracellular	intracellular	JJ
cord-306904-8iteddug	451	28	signaling	signal	VBG
cord-306904-8iteddug	451	29	cascade	cascade	NN
cord-306904-8iteddug	451	30	regulating	regulate	VBG
cord-306904-8iteddug	451	31	many	many	JJ
cord-306904-8iteddug	451	32	inflammatory	inflammatory	JJ
cord-306904-8iteddug	451	33	mediators	mediator	NNS
cord-306904-8iteddug	451	34	.	.	.
cord-306904-8iteddug	452	1	168	168	CD
cord-306904-8iteddug	452	2	NF	NF	NNP
cord-306904-8iteddug	452	3	-	-	HYPH
cord-306904-8iteddug	452	4	kB	kB	NNP
cord-306904-8iteddug	452	5	is	be	VBZ
cord-306904-8iteddug	452	6	a	a	DT
cord-306904-8iteddug	452	7	common	common	JJ
cord-306904-8iteddug	452	8	transcription	transcription	NN
cord-306904-8iteddug	452	9	factor	factor	NN
cord-306904-8iteddug	452	10	present	present	JJ
cord-306904-8iteddug	452	11	in	in	IN
cord-306904-8iteddug	452	12	almost	almost	RB
cord-306904-8iteddug	452	13	all	all	DT
cord-306904-8iteddug	452	14	cell	cell	NN
cord-306904-8iteddug	452	15	types	type	NNS
cord-306904-8iteddug	452	16	and	and	CC
cord-306904-8iteddug	452	17	is	be	VBZ
cord-306904-8iteddug	452	18	the	the	DT
cord-306904-8iteddug	452	19	endpoint	endpoint	NN
cord-306904-8iteddug	452	20	of	of	IN
cord-306904-8iteddug	452	21	a	a	DT
cord-306904-8iteddug	452	22	series	series	NN
cord-306904-8iteddug	452	23	of	of	IN
cord-306904-8iteddug	452	24	signal	signal	NN
cord-306904-8iteddug	452	25	transduction	transduction	NN
cord-306904-8iteddug	452	26	events	event	NNS
cord-306904-8iteddug	452	27	that	that	WDT
cord-306904-8iteddug	452	28	are	be	VBP
cord-306904-8iteddug	452	29	initiated	initiate	VBN
cord-306904-8iteddug	452	30	by	by	IN
cord-306904-8iteddug	452	31	a	a	DT
cord-306904-8iteddug	452	32	vast	vast	JJ
cord-306904-8iteddug	452	33	array	array	NN
cord-306904-8iteddug	452	34	of	of	IN
cord-306904-8iteddug	452	35	stimuli	stimulus	NNS
cord-306904-8iteddug	452	36	related	relate	VBN
cord-306904-8iteddug	452	37	to	to	IN
cord-306904-8iteddug	452	38	many	many	JJ
cord-306904-8iteddug	452	39	biological	biological	JJ
cord-306904-8iteddug	452	40	processes	process	NNS
cord-306904-8iteddug	452	41	such	such	JJ
cord-306904-8iteddug	452	42	as	as	IN
cord-306904-8iteddug	452	43	inflammation	inflammation	NN
cord-306904-8iteddug	452	44	,	,	,
cord-306904-8iteddug	452	45	immunity	immunity	NN
cord-306904-8iteddug	452	46	,	,	,
cord-306904-8iteddug	452	47	differentiation	differentiation	NN
cord-306904-8iteddug	452	48	,	,	,
cord-306904-8iteddug	452	49	cell	cell	NN
cord-306904-8iteddug	452	50	growth	growth	NN
cord-306904-8iteddug	452	51	,	,	,
cord-306904-8iteddug	452	52	tumorigenesis	tumorigenesis	NN
cord-306904-8iteddug	452	53	and	and	CC
cord-306904-8iteddug	452	54	apoptosis	apoptosis	NN
cord-306904-8iteddug	452	55	.	.	.
cord-306904-8iteddug	453	1	NF	NF	NNP
cord-306904-8iteddug	453	2	-	-	HYPH
cord-306904-8iteddug	453	3	kB	kB	NNP
cord-306904-8iteddug	453	4	is	be	VBZ
cord-306904-8iteddug	453	5	a	a	DT
cord-306904-8iteddug	453	6	homo	homo	NN
cord-306904-8iteddug	453	7	-	-	HYPH
cord-306904-8iteddug	453	8	or	or	CC
cord-306904-8iteddug	453	9	heterodimeric	heterodimeric	JJ
cord-306904-8iteddug	453	10	complex	complex	NN
cord-306904-8iteddug	453	11	formed	form	VBN
cord-306904-8iteddug	453	12	by	by	IN
cord-306904-8iteddug	453	13	the	the	DT
cord-306904-8iteddug	453	14	Rel	Rel	NNP
cord-306904-8iteddug	453	15	-	-	HYPH
cord-306904-8iteddug	453	16	like	like	JJ
cord-306904-8iteddug	453	17	domain	domain	NN
cord-306904-8iteddug	453	18	-	-	HYPH
cord-306904-8iteddug	453	19	containing	contain	VBG
cord-306904-8iteddug	453	20	proteins	protein	NNS
cord-306904-8iteddug	454	1	RELA	RELA	NNP
cord-306904-8iteddug	454	2	/	/	SYM
cord-306904-8iteddug	454	3	p65	p65	NN
cord-306904-8iteddug	454	4	,	,	,
cord-306904-8iteddug	454	5	RELB	RELB	NNP
cord-306904-8iteddug	454	6	,	,	,
cord-306904-8iteddug	454	7	NF	nf	NN
cord-306904-8iteddug	454	8	-	-	HYPH
cord-306904-8iteddug	454	9	kB1	kb1	JJ
cord-306904-8iteddug	455	1	/p105	/p105	NNP
cord-306904-8iteddug	455	2	,	,	,
cord-306904-8iteddug	455	3	NF	nf	NN
cord-306904-8iteddug	455	4	-	-	HYPH
cord-306904-8iteddug	455	5	kB1	kb1	JJ
cord-306904-8iteddug	455	6	/	/	SYM
cord-306904-8iteddug	455	7	p50	p50	NN
cord-306904-8iteddug	455	8	,	,	,
cord-306904-8iteddug	455	9	REL	REL	NNP
cord-306904-8iteddug	455	10	and	and	CC
cord-306904-8iteddug	455	11	NF	NF	NNP
cord-306904-8iteddug	455	12	-	-	HYPH
cord-306904-8iteddug	455	13	kB2	kB2	NNP
cord-306904-8iteddug	455	14	/	/	SYM
cord-306904-8iteddug	455	15	p52	p52	NN
cord-306904-8iteddug	455	16	,	,	,
cord-306904-8iteddug	455	17	and	and	CC
cord-306904-8iteddug	455	18	the	the	DT
cord-306904-8iteddug	455	19	heterodimeric	heterodimeric	NNP
cord-306904-8iteddug	455	20	p65-p50	p65-p50	NNP
cord-306904-8iteddug	455	21	complex	complex	JJ
cord-306904-8iteddug	455	22	.	.	.
cord-306904-8iteddug	456	1	Figure	figure	NN
cord-306904-8iteddug	456	2	13	13	CD
cord-306904-8iteddug	456	3	represents	represent	VBZ
cord-306904-8iteddug	456	4	the	the	DT
cord-306904-8iteddug	456	5	results	result	NNS
cord-306904-8iteddug	456	6	of	of	IN
cord-306904-8iteddug	456	7	the	the	DT
cord-306904-8iteddug	456	8	multiparametric	multiparametric	JJ
cord-306904-8iteddug	456	9	evaluation	evaluation	NN
cord-306904-8iteddug	456	10	of	of	IN
cord-306904-8iteddug	456	11	intrinsic	intrinsic	JJ
cord-306904-8iteddug	456	12	disorder	disorder	NN
cord-306904-8iteddug	456	13	propensities	propensity	NNS
cord-306904-8iteddug	456	14	of	of	IN
cord-306904-8iteddug	456	15	HSF-1	HSF-1	NNP
cord-306904-8iteddug	456	16	(	(	-LRB-
cord-306904-8iteddug	456	17	A	A	NNP
cord-306904-8iteddug	456	18	,	,	,
cord-306904-8iteddug	456	19	UniProt	UniProt	NNP
cord-306904-8iteddug	456	20	ID	ID	NNP
cord-306904-8iteddug	456	21	:	:	:
cord-306904-8iteddug	456	22	Q00613	Q00613	NNP
cord-306904-8iteddug	456	23	)	)	-RRB-
cord-306904-8iteddug	456	24	,	,	,
cord-306904-8iteddug	456	25	CREB	CREB	NNP
cord-306904-8iteddug	456	26	(	(	-LRB-
cord-306904-8iteddug	456	27	B	b	NN
cord-306904-8iteddug	456	28	,	,	,
cord-306904-8iteddug	456	29	UniProt	UniProt	NNP
cord-306904-8iteddug	456	30	ID	ID	NNP
cord-306904-8iteddug	456	31	:	:	:
cord-306904-8iteddug	456	32	P16220	P16220	NNP
cord-306904-8iteddug	456	33	)	)	-RRB-
cord-306904-8iteddug	456	34	,	,	,
cord-306904-8iteddug	456	35	NF	NF	NNP
cord-306904-8iteddug	456	36	-	-	HYPH
cord-306904-8iteddug	456	37	YA	YA	NNP
cord-306904-8iteddug	456	38	(	(	-LRB-
cord-306904-8iteddug	456	39	C	C	NNP
cord-306904-8iteddug	456	40	,	,	,
cord-306904-8iteddug	456	41	UniProt	UniProt	NNP
cord-306904-8iteddug	456	42	ID	ID	NNP
cord-306904-8iteddug	456	43	:	:	:
cord-306904-8iteddug	456	44	P23511	P23511	NNP
cord-306904-8iteddug	456	45	)	)	-RRB-
cord-306904-8iteddug	456	46	,	,	,
cord-306904-8iteddug	456	47	NF	NF	NNP
cord-306904-8iteddug	456	48	-	-	HYPH
cord-306904-8iteddug	456	49	YB	YB	NNP
cord-306904-8iteddug	456	50	(	(	-LRB-
cord-306904-8iteddug	456	51	D	D	NNP
cord-306904-8iteddug	456	52	,	,	,
cord-306904-8iteddug	456	53	UniProt	UniProt	NNP
cord-306904-8iteddug	456	54	ID	ID	NNP
cord-306904-8iteddug	456	55	:	:	:
cord-306904-8iteddug	456	56	P25208	P25208	NNP
cord-306904-8iteddug	456	57	)	)	-RRB-
cord-306904-8iteddug	456	58	,	,	,
cord-306904-8iteddug	456	59	NF	NF	NNP
cord-306904-8iteddug	456	60	-	-	HYPH
cord-306904-8iteddug	456	61	YC	YC	NNP
cord-306904-8iteddug	456	62	(	(	-LRB-
cord-306904-8iteddug	456	63	E	E	NNP
cord-306904-8iteddug	456	64	,	,	,
cord-306904-8iteddug	456	65	Uni	Uni	NNP
cord-306904-8iteddug	456	66	-	-	HYPH
cord-306904-8iteddug	456	67	Prot	Prot	NNP
cord-306904-8iteddug	456	68	ID	ID	NNP
cord-306904-8iteddug	456	69	:	:	:
cord-306904-8iteddug	456	70	Q13952	Q13952	NNP
cord-306904-8iteddug	456	71	)	)	-RRB-
cord-306904-8iteddug	456	72	,	,	,
cord-306904-8iteddug	456	73	and	and	CC
cord-306904-8iteddug	456	74	NF	NF	NNP
cord-306904-8iteddug	456	75	-	-	HYPH
cord-306904-8iteddug	456	76	kB	kB	NNP
cord-306904-8iteddug	456	77	(	(	-LRB-
cord-306904-8iteddug	456	78	F	F	NNP
cord-306904-8iteddug	456	79	,	,	,
cord-306904-8iteddug	456	80	UniProt	UniProt	NNP
cord-306904-8iteddug	456	81	ID	ID	NNP
cord-306904-8iteddug	456	82	:	:	:
cord-306904-8iteddug	456	83	P19838	P19838	NNP
cord-306904-8iteddug	456	84	)	)	-RRB-
cord-306904-8iteddug	456	85	and	and	CC
cord-306904-8iteddug	456	86	shows	show	VBZ
cord-306904-8iteddug	456	87	that	that	IN
cord-306904-8iteddug	456	88	these	these	DT
cord-306904-8iteddug	456	89	proteins	protein	NNS
cord-306904-8iteddug	456	90	are	be	VBP
cord-306904-8iteddug	456	91	predicted	predict	VBN
cord-306904-8iteddug	456	92	to	to	TO
cord-306904-8iteddug	456	93	be	be	VB
cord-306904-8iteddug	456	94	highly	highly	RB
cord-306904-8iteddug	456	95	disordered	disordered	JJ
cord-306904-8iteddug	456	96	.	.	.
cord-306904-8iteddug	457	1	The	the	DT
cord-306904-8iteddug	457	2	high	high	JJ
cord-306904-8iteddug	457	3	levels	level	NNS
cord-306904-8iteddug	457	4	of	of	IN
cord-306904-8iteddug	457	5	functional	functional	JJ
cord-306904-8iteddug	457	6	intrinsic	intrinsic	JJ
cord-306904-8iteddug	457	7	disorder	disorder	NN
cord-306904-8iteddug	457	8	is	be	VBZ
cord-306904-8iteddug	457	9	a	a	DT
cord-306904-8iteddug	457	10	"	"	``
cord-306904-8iteddug	457	11	family	family	NN
cord-306904-8iteddug	457	12	signature	signature	NN
cord-306904-8iteddug	457	13	"	"	''
cord-306904-8iteddug	457	14	of	of	IN
cord-306904-8iteddug	457	15	the	the	DT
cord-306904-8iteddug	457	16	transcription	transcription	NN
cord-306904-8iteddug	457	17	factors	factor	NNS
cord-306904-8iteddug	457	18	in	in	IN
cord-306904-8iteddug	457	19	general	general	JJ
cord-306904-8iteddug	457	20	.	.	.
cord-306904-8iteddug	457	21	169	169	CD
cord-306904-8iteddug	458	1	Furthermore	furthermore	RB
cord-306904-8iteddug	458	2	,	,	,
cord-306904-8iteddug	458	3	the	the	DT
cord-306904-8iteddug	458	4	recent	recent	JJ
cord-306904-8iteddug	458	5	analysis	analysis	NN
cord-306904-8iteddug	458	6	of	of	IN
cord-306904-8iteddug	458	7	the	the	DT
cord-306904-8iteddug	458	8	abundance	abundance	NN
cord-306904-8iteddug	458	9	and	and	CC
cord-306904-8iteddug	458	10	importance	importance	NN
cord-306904-8iteddug	458	11	of	of	IN
cord-306904-8iteddug	458	12	IDPRs	IDPRs	NNPS
cord-306904-8iteddug	458	13	in	in	IN
cord-306904-8iteddug	458	14	functions	function	NNS
cord-306904-8iteddug	458	15	of	of	IN
cord-306904-8iteddug	458	16	various	various	JJ
cord-306904-8iteddug	458	17	HSFs	hsf	NNS
cord-306904-8iteddug	458	18	clearly	clearly	RB
cord-306904-8iteddug	458	19	indicated	indicate	VBD
cord-306904-8iteddug	458	20	that	that	IN
cord-306904-8iteddug	458	21	the	the	DT
cord-306904-8iteddug	458	22	heat	heat	NN
cord-306904-8iteddug	458	23	shock	shock	NN
cord-306904-8iteddug	458	24	response	response	NN
cord-306904-8iteddug	458	25	requires	require	VBZ
cord-306904-8iteddug	458	26	HSF	HSF	NNP
cord-306904-8iteddug	458	27	flexibility	flexibility	NN
cord-306904-8iteddug	458	28	to	to	TO
cord-306904-8iteddug	458	29	be	be	VB
cord-306904-8iteddug	458	30	more	more	RBR
cord-306904-8iteddug	458	31	efficient	efficient	JJ
cord-306904-8iteddug	458	32	.	.	.
cord-306904-8iteddug	459	1	170	170	CD
cord-306904-8iteddug	460	1	Also	also	RB
cord-306904-8iteddug	460	2	,	,	,
cord-306904-8iteddug	460	3	the	the	DT
cord-306904-8iteddug	460	4	importance	importance	NN
cord-306904-8iteddug	460	5	of	of	IN
cord-306904-8iteddug	460	6	intrinsic	intrinsic	JJ
cord-306904-8iteddug	460	7	disorder	disorder	NN
cord-306904-8iteddug	460	8	in	in	IN
cord-306904-8iteddug	460	9	functions	function	NNS
cord-306904-8iteddug	460	10	of	of	IN
cord-306904-8iteddug	460	11	various	various	JJ
cord-306904-8iteddug	460	12	proteins	protein	NNS
cord-306904-8iteddug	460	13	involved	involve	VBN
cord-306904-8iteddug	460	14	in	in	IN
cord-306904-8iteddug	460	15	the	the	DT
cord-306904-8iteddug	460	16	innate	innate	JJ
cord-306904-8iteddug	460	17	immune	immune	JJ
cord-306904-8iteddug	460	18	response	response	NN
cord-306904-8iteddug	460	19	(	(	-LRB-
cord-306904-8iteddug	460	20	including	include	VBG
cord-306904-8iteddug	460	21	NF	nf	NN
cord-306904-8iteddug	460	22	-	-	HYPH
cord-306904-8iteddug	460	23	kB	kB	NNP
cord-306904-8iteddug	460	24	)	)	-RRB-
cord-306904-8iteddug	460	25	has	have	VBZ
cord-306904-8iteddug	460	26	been	be	VBN
cord-306904-8iteddug	460	27	recently	recently	RB
cord-306904-8iteddug	460	28	analyzed	analyze	VBN
cord-306904-8iteddug	460	29	.	.	.
cord-306904-8iteddug	461	1	171	171	CD
cord-306904-8iteddug	461	2	Phosphorylation	Phosphorylation	NNP
cord-306904-8iteddug	461	3	sites	site	NNS
cord-306904-8iteddug	461	4	in	in	IN
cord-306904-8iteddug	461	5	melanopsin	melanopsin	NNS
cord-306904-8iteddug	461	6	Blasic	Blasic	NNP
cord-306904-8iteddug	461	7	et	et	NNP
cord-306904-8iteddug	461	8	al	al	NNP
cord-306904-8iteddug	461	9	.	.	.
cord-306904-8iteddug	461	10	analyzed	analyze	VBD
cord-306904-8iteddug	461	11	the	the	DT
cord-306904-8iteddug	461	12	peculiarities	peculiarity	NNS
cord-306904-8iteddug	461	13	of	of	IN
cord-306904-8iteddug	461	14	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	461	15	of	of	IN
cord-306904-8iteddug	461	16	the	the	DT
cord-306904-8iteddug	461	17	C	c	NN
cord-306904-8iteddug	461	18	-	-	HYPH
cord-306904-8iteddug	461	19	terminal	terminal	NN
cord-306904-8iteddug	461	20	domain	domain	NN
cord-306904-8iteddug	461	21	of	of	IN
cord-306904-8iteddug	461	22	the	the	DT
cord-306904-8iteddug	461	23	photopigment	photopigment	JJ
cord-306904-8iteddug	461	24	melanopsin	melanopsin	NNP
cord-306904-8iteddug	461	25	possessing	possess	VBG
cord-306904-8iteddug	461	26	37	37	CD
cord-306904-8iteddug	461	27	serine	serine	NN
cord-306904-8iteddug	461	28	and	and	CC
cord-306904-8iteddug	461	29	threonine	threonine	NN
cord-306904-8iteddug	461	30	sites	site	NNS
cord-306904-8iteddug	461	31	that	that	WDT
cord-306904-8iteddug	461	32	are	be	VBP
cord-306904-8iteddug	461	33	potential	potential	JJ
cord-306904-8iteddug	461	34	sites	site	NNS
cord-306904-8iteddug	461	35	for	for	IN
cord-306904-8iteddug	461	36	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	461	37	by	by	IN
cord-306904-8iteddug	461	38	a	a	DT
cord-306904-8iteddug	461	39	G	g	NN
cord-306904-8iteddug	461	40	-	-	HYPH
cord-306904-8iteddug	461	41	protein	protein	NN
cord-306904-8iteddug	461	42	dependent	dependent	JJ
cord-306904-8iteddug	461	43	kinase	kinase	NN
cord-306904-8iteddug	461	44	(	(	-LRB-
cord-306904-8iteddug	461	45	GRK	GRK	NNP
cord-306904-8iteddug	461	46	)	)	-RRB-
cord-306904-8iteddug	461	47	.	.	.
cord-306904-8iteddug	462	1	172	172	CD
cord-306904-8iteddug	462	2	Melanopsin	Melanopsin	NNPS
cord-306904-8iteddug	462	3	is	be	VBZ
cord-306904-8iteddug	462	4	a	a	DT
cord-306904-8iteddug	462	5	member	member	NN
cord-306904-8iteddug	462	6	of	of	IN
cord-306904-8iteddug	462	7	the	the	DT
cord-306904-8iteddug	462	8	G	G	NNP
cord-306904-8iteddug	462	9	protein	protein	NN
cord-306904-8iteddug	462	10	coupled	couple	VBN
cord-306904-8iteddug	462	11	receptor	receptor	NN
cord-306904-8iteddug	462	12	(	(	-LRB-
cord-306904-8iteddug	462	13	GPCR	GPCR	NNP
cord-306904-8iteddug	462	14	)	)	-RRB-
cord-306904-8iteddug	462	15	family	family	NN
cord-306904-8iteddug	462	16	that	that	WDT
cord-306904-8iteddug	462	17	undergoes	undergo	VBZ
cord-306904-8iteddug	462	18	light	light	JJ
cord-306904-8iteddug	462	19	-	-	HYPH
cord-306904-8iteddug	462	20	dependent	dependent	JJ
cord-306904-8iteddug	462	21	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	462	22	that	that	WDT
cord-306904-8iteddug	462	23	is	be	VBZ
cord-306904-8iteddug	462	24	involved	involve	VBN
cord-306904-8iteddug	462	25	in	in	IN
cord-306904-8iteddug	462	26	deactivation	deactivation	NN
cord-306904-8iteddug	462	27	of	of	IN
cord-306904-8iteddug	462	28	the	the	DT
cord-306904-8iteddug	462	29	photoresponse	photoresponse	NN
cord-306904-8iteddug	462	30	.	.	.
cord-306904-8iteddug	463	1	Blasic	Blasic	NNP
cord-306904-8iteddug	463	2	et	et	NNP
cord-306904-8iteddug	463	3	al	al	NNP
cord-306904-8iteddug	463	4	.	.	NNP
cord-306904-8iteddug	463	5	revealed	reveal	VBD
cord-306904-8iteddug	463	6	that	that	DT
cord-306904-8iteddug	463	7	of	of	IN
cord-306904-8iteddug	463	8	the	the	DT
cord-306904-8iteddug	463	9	37	37	CD
cord-306904-8iteddug	463	10	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	463	11	sites	site	NNS
cord-306904-8iteddug	463	12	,	,	,
cord-306904-8iteddug	463	13	a	a	DT
cord-306904-8iteddug	463	14	small	small	JJ
cord-306904-8iteddug	463	15	cluster	cluster	NN
cord-306904-8iteddug	463	16	of	of	IN
cord-306904-8iteddug	463	17	6	6	CD
cord-306904-8iteddug	463	18	or	or	CC
cord-306904-8iteddug	463	19	7	7	CD
cord-306904-8iteddug	463	20	sites	site	NNS
cord-306904-8iteddug	463	21	in	in	IN
cord-306904-8iteddug	463	22	the	the	DT
cord-306904-8iteddug	463	23	proximal	proximal	JJ
cord-306904-8iteddug	463	24	region	region	NN
cord-306904-8iteddug	463	25	of	of	IN
cord-306904-8iteddug	463	26	the	the	DT
cord-306904-8iteddug	463	27	C	C	NNP
cord-306904-8iteddug	463	28	-	-	HYPH
cord-306904-8iteddug	463	29	tail	tail	NN
cord-306904-8iteddug	463	30	is	be	VBZ
cord-306904-8iteddug	463	31	critical	critical	JJ
cord-306904-8iteddug	463	32	for	for	IN
cord-306904-8iteddug	463	33	mediating	mediate	VBG
cord-306904-8iteddug	463	34	deactivation	deactivation	NN
cord-306904-8iteddug	463	35	.	.	.
cord-306904-8iteddug	464	1	172	172	CD
cord-306904-8iteddug	464	2	Figure	figure	NN
cord-306904-8iteddug	464	3	14A	14A	NNS
cord-306904-8iteddug	464	4	shows	show	VBZ
cord-306904-8iteddug	464	5	that	that	IN
cord-306904-8iteddug	464	6	mouse	mouse	NN
cord-306904-8iteddug	464	7	melanopsin	melanopsin	NNP
cord-306904-8iteddug	464	8	(	(	-LRB-
cord-306904-8iteddug	464	9	UniProt	UniProt	NNP
cord-306904-8iteddug	464	10	ID	ID	NNP
cord-306904-8iteddug	464	11	:	:	:
cord-306904-8iteddug	464	12	Q9QXZ9	q9qxz9	NN
cord-306904-8iteddug	464	13	)	)	-RRB-
cord-306904-8iteddug	464	14	is	be	VBZ
cord-306904-8iteddug	464	15	predicted	predict	VBN
cord-306904-8iteddug	464	16	to	to	TO
cord-306904-8iteddug	464	17	have	have	VB
cord-306904-8iteddug	464	18	long	long	JJ
cord-306904-8iteddug	464	19	disordered	disordered	JJ
cord-306904-8iteddug	464	20	C	c	NN
cord-306904-8iteddug	464	21	-	-	HYPH
cord-306904-8iteddug	464	22	tail	tail	NN
cord-306904-8iteddug	464	23	(	(	-LRB-
cord-306904-8iteddug	464	24	residues	residue	NNS
cord-306904-8iteddug	464	25	380	380	CD
cord-306904-8iteddug	464	26	-	-	SYM
cord-306904-8iteddug	464	27	521	521	CD
cord-306904-8iteddug	464	28	)	)	-RRB-
cord-306904-8iteddug	464	29	.	.	.
cord-306904-8iteddug	465	1	This	this	DT
cord-306904-8iteddug	465	2	is	be	VBZ
cord-306904-8iteddug	465	3	a	a	DT
cord-306904-8iteddug	465	4	rather	rather	RB
cord-306904-8iteddug	465	5	expected	expect	VBN
cord-306904-8iteddug	465	6	output	output	NN
cord-306904-8iteddug	465	7	since	since	IN
cord-306904-8iteddug	465	8	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	465	9	sites	site	NNS
cord-306904-8iteddug	465	10	are	be	VBP
cord-306904-8iteddug	465	11	known	know	VBN
cord-306904-8iteddug	465	12	to	to	TO
cord-306904-8iteddug	465	13	be	be	VB
cord-306904-8iteddug	465	14	preferentially	preferentially	RB
cord-306904-8iteddug	465	15	located	locate	VBN
cord-306904-8iteddug	465	16	within	within	IN
cord-306904-8iteddug	465	17	the	the	DT
cord-306904-8iteddug	465	18	IDPRs	IDPRs	NNPS
cord-306904-8iteddug	465	19	.	.	.
cord-306904-8iteddug	466	1	[	[	-LRB-
cord-306904-8iteddug	466	2	173	173	CD
cord-306904-8iteddug	466	3	]	]	-RRB-
cord-306904-8iteddug	466	4	[	[	-LRB-
cord-306904-8iteddug	466	5	174	174	CD
cord-306904-8iteddug	466	6	]	]	-RRB-
cord-306904-8iteddug	466	7	[	[	-LRB-
cord-306904-8iteddug	466	8	175	175	CD
cord-306904-8iteddug	466	9	]	]	-RRB-
cord-306904-8iteddug	467	1	Human	human	JJ
cord-306904-8iteddug	467	2	defensins	defensin	NNS
cord-306904-8iteddug	468	1	A	a	DT
cord-306904-8iteddug	468	2	recent	recent	JJ
cord-306904-8iteddug	468	3	review	review	NN
cord-306904-8iteddug	468	4	of	of	IN
cord-306904-8iteddug	468	5	Wisons	Wisons	NNP
cord-306904-8iteddug	468	6	et	et	NNP
cord-306904-8iteddug	468	7	al	al	NNP
cord-306904-8iteddug	468	8	.	.	NNP
cord-306904-8iteddug	468	9	is	be	VBZ
cord-306904-8iteddug	468	10	dedicated	dedicate	VBN
cord-306904-8iteddug	468	11	to	to	IN
cord-306904-8iteddug	468	12	the	the	DT
cord-306904-8iteddug	468	13	antiviral	antiviral	JJ
cord-306904-8iteddug	468	14	activities	activity	NNS
cord-306904-8iteddug	468	15	of	of	IN
cord-306904-8iteddug	468	16	human	human	JJ
cord-306904-8iteddug	468	17	defensins	defensin	NNS
cord-306904-8iteddug	468	18	.	.	.
cord-306904-8iteddug	469	1	176	176	CD
cord-306904-8iteddug	470	1	These	these	DT
cord-306904-8iteddug	470	2	peptides	peptide	NNS
cord-306904-8iteddug	470	3	with	with	IN
cord-306904-8iteddug	470	4	a	a	DT
cord-306904-8iteddug	470	5	wide	wide	JJ
cord-306904-8iteddug	470	6	range	range	NN
cord-306904-8iteddug	470	7	of	of	IN
cord-306904-8iteddug	470	8	antimicrobial	antimicrobial	JJ
cord-306904-8iteddug	470	9	activities	activity	NNS
cord-306904-8iteddug	470	10	are	be	VBP
cord-306904-8iteddug	470	11	important	important	JJ
cord-306904-8iteddug	470	12	components	component	NNS
cord-306904-8iteddug	470	13	of	of	IN
cord-306904-8iteddug	470	14	the	the	DT
cord-306904-8iteddug	470	15	innate	innate	JJ
cord-306904-8iteddug	470	16	immune	immune	JJ
cord-306904-8iteddug	470	17	system	system	NN
cord-306904-8iteddug	470	18	.	.	.
cord-306904-8iteddug	471	1	Among	among	IN
cord-306904-8iteddug	471	2	various	various	JJ
cord-306904-8iteddug	471	3	antiviral	antiviral	JJ
cord-306904-8iteddug	471	4	mechanisms	mechanism	NNS
cord-306904-8iteddug	471	5	of	of	IN
cord-306904-8iteddug	471	6	human	human	JJ
cord-306904-8iteddug	471	7	defensins	defensin	NNS
cord-306904-8iteddug	471	8	are	be	VBP
cord-306904-8iteddug	471	9	direct	direct	JJ
cord-306904-8iteddug	471	10	targeting	targeting	NN
cord-306904-8iteddug	471	11	of	of	IN
cord-306904-8iteddug	471	12	viral	viral	JJ
cord-306904-8iteddug	471	13	envelopes	envelope	NNS
cord-306904-8iteddug	471	14	,	,	,
cord-306904-8iteddug	471	15	glycoproteins	glycoprotein	NNS
cord-306904-8iteddug	471	16	,	,	,
cord-306904-8iteddug	471	17	and	and	CC
cord-306904-8iteddug	471	18	capsids	capsid	NNS
cord-306904-8iteddug	471	19	,	,	,
cord-306904-8iteddug	471	20	inhibition	inhibition	NN
cord-306904-8iteddug	471	21	of	of	IN
cord-306904-8iteddug	471	22	viral	viral	JJ
cord-306904-8iteddug	471	23	fusion	fusion	NN
cord-306904-8iteddug	471	24	and	and	CC
cord-306904-8iteddug	471	25	post	post	JJ
cord-306904-8iteddug	471	26	-	-	JJ
cord-306904-8iteddug	471	27	entry	entry	JJ
cord-306904-8iteddug	471	28	neutralization	neutralization	NN
cord-306904-8iteddug	471	29	,	,	,
cord-306904-8iteddug	471	30	inhibition	inhibition	NN
cord-306904-8iteddug	471	31	of	of	IN
cord-306904-8iteddug	471	32	viral	viral	JJ
cord-306904-8iteddug	471	33	replication	replication	NN
cord-306904-8iteddug	471	34	via	via	IN
cord-306904-8iteddug	471	35	disruption	disruption	NN
cord-306904-8iteddug	471	36	of	of	IN
cord-306904-8iteddug	471	37	host	host	NN
cord-306904-8iteddug	471	38	intracellular	intracellular	JJ
cord-306904-8iteddug	471	39	signaling	signaling	NN
cord-306904-8iteddug	471	40	and	and	CC
cord-306904-8iteddug	471	41	binding	binding	NN
cord-306904-8iteddug	471	42	and	and	CC
cord-306904-8iteddug	471	43	modulation	modulation	NN
cord-306904-8iteddug	471	44	of	of	IN
cord-306904-8iteddug	471	45	host	host	NN
cord-306904-8iteddug	471	46	cell	cell	NN
cord-306904-8iteddug	471	47	surface	surface	NN
cord-306904-8iteddug	471	48	receptors	receptor	NNS
cord-306904-8iteddug	471	49	,	,	,
cord-306904-8iteddug	471	50	and	and	CC
cord-306904-8iteddug	471	51	augmentation	augmentation	NN
cord-306904-8iteddug	471	52	and	and	CC
cord-306904-8iteddug	471	53	altering	altering	NN
cord-306904-8iteddug	471	54	of	of	IN
cord-306904-8iteddug	471	55	adaptive	adaptive	JJ
cord-306904-8iteddug	471	56	immune	immune	JJ
cord-306904-8iteddug	471	57	responses	response	NNS
cord-306904-8iteddug	471	58	.	.	.
cord-306904-8iteddug	472	1	176	176	CD
cord-306904-8iteddug	473	1	Of	of	IN
cord-306904-8iteddug	473	2	the	the	DT
cord-306904-8iteddug	473	3	2	2	CD
cord-306904-8iteddug	473	4	types	type	NNS
cord-306904-8iteddug	473	5	of	of	IN
cord-306904-8iteddug	473	6	defensins	defensin	NNS
cord-306904-8iteddug	473	7	,	,	,
cord-306904-8iteddug	473	8	aand	aand	NNP
cord-306904-8iteddug	473	9	b	b	NNP
cord-306904-8iteddug	473	10	-	-	:
cord-306904-8iteddug	473	11	defensins	defensins	NNP
cord-306904-8iteddug	473	12	,	,	,
cord-306904-8iteddug	473	13	found	find	VBN
cord-306904-8iteddug	473	14	in	in	IN
cord-306904-8iteddug	473	15	human	human	JJ
cord-306904-8iteddug	473	16	,	,	,
cord-306904-8iteddug	473	17	significant	significant	JJ
cord-306904-8iteddug	473	18	knowledge	knowledge	NN
cord-306904-8iteddug	473	19	is	be	VBZ
cord-306904-8iteddug	473	20	accumulated	accumulate	VBN
cord-306904-8iteddug	473	21	about	about	IN
cord-306904-8iteddug	473	22	the	the	DT
cord-306904-8iteddug	473	23	molecular	molecular	JJ
cord-306904-8iteddug	473	24	mechanisms	mechanism	NNS
cord-306904-8iteddug	473	25	of	of	IN
cord-306904-8iteddug	473	26	the	the	DT
cord-306904-8iteddug	473	27	a	a	DT
cord-306904-8iteddug	473	28	-	-	HYPH
cord-306904-8iteddug	473	29	defensin	defensin	NN
cord-306904-8iteddug	473	30	action	action	NN
cord-306904-8iteddug	473	31	,	,	,
cord-306904-8iteddug	473	32	whereas	whereas	IN
cord-306904-8iteddug	473	33	molecular	molecular	JJ
cord-306904-8iteddug	473	34	details	detail	NNS
cord-306904-8iteddug	473	35	on	on	IN
cord-306904-8iteddug	473	36	the	the	DT
cord-306904-8iteddug	473	37	b	b	NN
cord-306904-8iteddug	473	38	-	-	HYPH
cord-306904-8iteddug	473	39	defensin	defensin	NN
cord-306904-8iteddug	473	40	activities	activity	NNS
cord-306904-8iteddug	473	41	are	be	VBP
cord-306904-8iteddug	473	42	more	more	JJR
cord-306904-8iteddug	473	43	disperse	disperse	NN
cord-306904-8iteddug	473	44	.	.	.
cord-306904-8iteddug	474	1	176	176	CD
cord-306904-8iteddug	474	2	Defensins	defensin	NNS
cord-306904-8iteddug	474	3	are	be	VBP
cord-306904-8iteddug	474	4	small	small	JJ
cord-306904-8iteddug	475	1	(	(	-LRB-
cord-306904-8iteddug	475	2	»	»	``
cord-306904-8iteddug	475	3	29	29	CD
cord-306904-8iteddug	475	4	-	-	SYM
cord-306904-8iteddug	475	5	129	129	CD
cord-306904-8iteddug	475	6	amino	amino	JJ
cord-306904-8iteddug	475	7	acids	acid	NNS
cord-306904-8iteddug	475	8	)	)	-RRB-
cord-306904-8iteddug	475	9	cationic	cationic	NN
cord-306904-8iteddug	475	10	,	,	,
cord-306904-8iteddug	475	11	amphipathic	amphipathic	NNP
cord-306904-8iteddug	475	12	polypeptides	polypeptide	NNS
cord-306904-8iteddug	475	13	with	with	IN
cord-306904-8iteddug	475	14	a	a	DT
cord-306904-8iteddug	475	15	predominantly	predominantly	RB
cord-306904-8iteddug	475	16	b	b	NN
cord-306904-8iteddug	475	17	-	-	HYPH
cord-306904-8iteddug	475	18	sheet	sheet	NN
cord-306904-8iteddug	475	19	structure	structure	NN
cord-306904-8iteddug	475	20	stabilized	stabilize	VBN
cord-306904-8iteddug	475	21	by	by	IN
cord-306904-8iteddug	475	22	3	3	CD
cord-306904-8iteddug	475	23	disulfide	disulfide	JJ
cord-306904-8iteddug	475	24	bonds	bond	NNS
cord-306904-8iteddug	475	25	.	.	.
cord-306904-8iteddug	476	1	176	176	CD
cord-306904-8iteddug	476	2	Human	Human	NNP
cord-306904-8iteddug	476	3	a	a	DT
cord-306904-8iteddug	476	4	-	-	HYPH
cord-306904-8iteddug	476	5	defensins	defensin	NNS
cord-306904-8iteddug	476	6	are	be	VBP
cord-306904-8iteddug	476	7	typically	typically	RB
cord-306904-8iteddug	476	8	shorter	short	JJR
cord-306904-8iteddug	476	9	than	than	IN
cord-306904-8iteddug	476	10	b	b	NN
cord-306904-8iteddug	476	11	-	-	HYPH
cord-306904-8iteddug	476	12	defensins	defensins	NNP
cord-306904-8iteddug	476	13	,	,	,
cord-306904-8iteddug	476	14	with	with	IN
cord-306904-8iteddug	476	15	a	a	DT
cord-306904-8iteddug	476	16	-	-	HYPH
cord-306904-8iteddug	476	17	defensins	defensin	NNS
cord-306904-8iteddug	476	18	staying	stay	VBG
cord-306904-8iteddug	476	19	in	in	IN
cord-306904-8iteddug	476	20	a	a	DT
cord-306904-8iteddug	476	21	range	range	NN
cord-306904-8iteddug	476	22	of	of	IN
cord-306904-8iteddug	476	23	29	29	CD
cord-306904-8iteddug	476	24	-	-	SYM
cord-306904-8iteddug	476	25	39	39	CD
cord-306904-8iteddug	476	26	residues	residue	NNS
cord-306904-8iteddug	476	27	and	and	CC
cord-306904-8iteddug	476	28	some	some	DT
cord-306904-8iteddug	476	29	b	b	NN
cord-306904-8iteddug	476	30	-	-	HYPH
cord-306904-8iteddug	476	31	defensins	defensins	NNP
cord-306904-8iteddug	476	32	can	can	MD
cord-306904-8iteddug	476	33	being	be	VBG
cord-306904-8iteddug	476	34	as	as	RB
cord-306904-8iteddug	476	35	long	long	JJ
cord-306904-8iteddug	476	36	as	as	IN
cord-306904-8iteddug	476	37	129	129	CD
cord-306904-8iteddug	476	38	residues	residue	NNS
cord-306904-8iteddug	476	39	.	.	.
cord-306904-8iteddug	477	1	Search	search	NN
cord-306904-8iteddug	477	2	of	of	IN
cord-306904-8iteddug	477	3	UniProt	UniProt	NNP
cord-306904-8iteddug	477	4	for	for	IN
cord-306904-8iteddug	477	5	human	human	JJ
cord-306904-8iteddug	477	6	defensins	defensin	NNS
cord-306904-8iteddug	477	7	produces	produce	VBZ
cord-306904-8iteddug	477	8	about	about	IN
cord-306904-8iteddug	477	9	40	40	CD
cord-306904-8iteddug	477	10	hits	hit	NNS
cord-306904-8iteddug	477	11	,	,	,
cord-306904-8iteddug	477	12	of	of	IN
cord-306904-8iteddug	477	13	which	which	WDT
cord-306904-8iteddug	477	14	6	6	CD
cord-306904-8iteddug	477	15	entries	entry	NNS
cord-306904-8iteddug	477	16	were	be	VBD
cord-306904-8iteddug	477	17	a	a	DT
cord-306904-8iteddug	477	18	-	-	HYPH
cord-306904-8iteddug	477	19	defensins	defensin	NNS
cord-306904-8iteddug	477	20	.	.	.
cord-306904-8iteddug	478	1	Defensins	defensin	NNS
cord-306904-8iteddug	478	2	are	be	VBP
cord-306904-8iteddug	478	3	produced	produce	VBN
cord-306904-8iteddug	478	4	in	in	IN
cord-306904-8iteddug	478	5	a	a	DT
cord-306904-8iteddug	478	6	form	form	NN
cord-306904-8iteddug	478	7	of	of	IN
cord-306904-8iteddug	478	8	proprotein	proprotein	NNP
cord-306904-8iteddug	478	9	containing	contain	VBG
cord-306904-8iteddug	478	10	a	a	DT
cord-306904-8iteddug	478	11	signal	signal	NN
cord-306904-8iteddug	478	12	peptide	peptide	NN
cord-306904-8iteddug	478	13	and/or	and/or	CC
cord-306904-8iteddug	478	14	a	a	DT
cord-306904-8iteddug	478	15	propeptide	propeptide	NN
cord-306904-8iteddug	478	16	.	.	.
cord-306904-8iteddug	479	1	Figure	figure	NN
cord-306904-8iteddug	479	2	15	15	CD
cord-306904-8iteddug	479	3	represents	represent	VBZ
cord-306904-8iteddug	479	4	disorder	disorder	NN
cord-306904-8iteddug	479	5	profile	profile	NN
cord-306904-8iteddug	479	6	for	for	IN
cord-306904-8iteddug	479	7	several	several	JJ
cord-306904-8iteddug	479	8	representative	representative	JJ
cord-306904-8iteddug	479	9	members	member	NNS
cord-306904-8iteddug	479	10	of	of	IN
cord-306904-8iteddug	479	11	the	the	DT
cord-306904-8iteddug	479	12	human	human	JJ
cord-306904-8iteddug	479	13	defensin	defensin	NNP
cord-306904-8iteddug	479	14	family	family	NN
cord-306904-8iteddug	479	15	and	and	CC
cord-306904-8iteddug	479	16	shows	show	VBZ
cord-306904-8iteddug	479	17	that	that	IN
cord-306904-8iteddug	479	18	all	all	DT
cord-306904-8iteddug	479	19	proproteins	proprotein	NNS
cord-306904-8iteddug	479	20	possess	possess	VBP
cord-306904-8iteddug	479	21	noticeable	noticeable	JJ
cord-306904-8iteddug	479	22	amount	amount	NN
cord-306904-8iteddug	479	23	of	of	IN
cord-306904-8iteddug	479	24	intrinsic	intrinsic	JJ
cord-306904-8iteddug	479	25	disorder	disorder	NN
cord-306904-8iteddug	479	26	,	,	,
cord-306904-8iteddug	479	27	the	the	DT
cord-306904-8iteddug	479	28	content	content	NN
cord-306904-8iteddug	479	29	of	of	IN
cord-306904-8iteddug	479	30	which	which	WDT
cord-306904-8iteddug	479	31	varies	vary	VBZ
cord-306904-8iteddug	479	32	significantly	significantly	RB
cord-306904-8iteddug	479	33	between	between	IN
cord-306904-8iteddug	479	34	different	different	JJ
cord-306904-8iteddug	479	35	defensins	defensin	NNS
cord-306904-8iteddug	479	36	.	.	.
cord-306904-8iteddug	480	1	It	-PRON-	PRP
cord-306904-8iteddug	480	2	is	be	VBZ
cord-306904-8iteddug	480	3	likely	likely	JJ
cord-306904-8iteddug	480	4	that	that	IN
cord-306904-8iteddug	480	5	the	the	DT
cord-306904-8iteddug	480	6	presence	presence	NN
cord-306904-8iteddug	480	7	of	of	IN
cord-306904-8iteddug	480	8	noticeable	noticeable	JJ
cord-306904-8iteddug	480	9	disordered	disordered	JJ
cord-306904-8iteddug	480	10	tails	tail	NNS
cord-306904-8iteddug	480	11	plays	play	VBZ
cord-306904-8iteddug	480	12	a	a	DT
cord-306904-8iteddug	480	13	role	role	NN
cord-306904-8iteddug	480	14	in	in	IN
cord-306904-8iteddug	480	15	the	the	DT
cord-306904-8iteddug	480	16	maturation	maturation	NN
cord-306904-8iteddug	480	17	of	of	IN
cord-306904-8iteddug	480	18	defensins	defensin	NNS
cord-306904-8iteddug	480	19	since	since	IN
cord-306904-8iteddug	480	20	sites	site	NNS
cord-306904-8iteddug	480	21	of	of	IN
cord-306904-8iteddug	480	22	the	the	DT
cord-306904-8iteddug	480	23	proteolytic	proteolytic	JJ
cord-306904-8iteddug	480	24	attack	attack	NN
cord-306904-8iteddug	480	25	are	be	VBP
cord-306904-8iteddug	480	26	commonly	commonly	RB
cord-306904-8iteddug	480	27	located	locate	VBN
cord-306904-8iteddug	480	28	within	within	IN
cord-306904-8iteddug	480	29	regions	region	NNS
cord-306904-8iteddug	480	30	of	of	IN
cord-306904-8iteddug	480	31	intrinsic	intrinsic	JJ
cord-306904-8iteddug	480	32	disorder	disorder	NN
cord-306904-8iteddug	480	33	.	.	.
cord-306904-8iteddug	481	1	177	177	CD
cord-306904-8iteddug	482	1	It	-PRON-	PRP
cord-306904-8iteddug	482	2	is	be	VBZ
cord-306904-8iteddug	482	3	also	also	RB
cord-306904-8iteddug	482	4	possible	possible	JJ
cord-306904-8iteddug	482	5	that	that	IN
cord-306904-8iteddug	482	6	these	these	DT
cord-306904-8iteddug	482	7	disordered	disordered	JJ
cord-306904-8iteddug	482	8	tails	tail	NNS
cord-306904-8iteddug	482	9	serve	serve	VBP
cord-306904-8iteddug	482	10	as	as	IN
cord-306904-8iteddug	482	11	entropic	entropic	JJ
cord-306904-8iteddug	482	12	bristle	bristle	NN
cord-306904-8iteddug	482	13	domains	domain	NNS
cord-306904-8iteddug	482	14	178	178	CD
cord-306904-8iteddug	482	15	 	 	_SP
cord-306904-8iteddug	482	16	Burke	Burke	NNP
cord-306904-8iteddug	482	17	et	et	NNP
cord-306904-8iteddug	482	18	al	al	NNP
cord-306904-8iteddug	482	19	.	.	.
cord-306904-8iteddug	483	1	investigated	investigate	VBD
cord-306904-8iteddug	483	2	the	the	DT
cord-306904-8iteddug	483	3	roles	role	NNS
cord-306904-8iteddug	483	4	of	of	IN
cord-306904-8iteddug	483	5	the	the	DT
cord-306904-8iteddug	483	6	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	483	7	of	of	IN
cord-306904-8iteddug	483	8	the	the	DT
cord-306904-8iteddug	483	9	C	c	NN
cord-306904-8iteddug	483	10	-	-	HYPH
cord-306904-8iteddug	483	11	terminal	terminal	NN
cord-306904-8iteddug	483	12	domain	domain	NN
cord-306904-8iteddug	483	13	of	of	IN
cord-306904-8iteddug	483	14	the	the	DT
cord-306904-8iteddug	483	15	retinoblastoma	retinoblastoma	NN
cord-306904-8iteddug	483	16	protein	protein	NN
cord-306904-8iteddug	483	17	(	(	-LRB-
cord-306904-8iteddug	483	18	RbC	rbc	NN
cord-306904-8iteddug	483	19	)	)	-RRB-
cord-306904-8iteddug	483	20	in	in	IN
cord-306904-8iteddug	483	21	interaction	interaction	NN
cord-306904-8iteddug	483	22	of	of	IN
cord-306904-8iteddug	483	23	Rb	Rb	NNP
cord-306904-8iteddug	483	24	with	with	IN
cord-306904-8iteddug	483	25	the	the	DT
cord-306904-8iteddug	483	26	E2F	E2F	NNP
cord-306904-8iteddug	483	27	transcription	transcription	NN
cord-306904-8iteddug	483	28	factor	factor	NN
cord-306904-8iteddug	483	29	and	and	CC
cord-306904-8iteddug	483	30	related	related	JJ
cord-306904-8iteddug	483	31	regulation	regulation	NN
cord-306904-8iteddug	483	32	of	of	IN
cord-306904-8iteddug	483	33	the	the	DT
cord-306904-8iteddug	483	34	Rb	Rb	NNP
cord-306904-8iteddug	483	35	activities	activity	NNS
cord-306904-8iteddug	483	36	in	in	IN
cord-306904-8iteddug	483	37	growth	growth	NN
cord-306904-8iteddug	483	38	suppression	suppression	NN
cord-306904-8iteddug	483	39	.	.	.
cord-306904-8iteddug	484	1	179	179	CD
cord-306904-8iteddug	484	2	Deregulation	deregulation	NN
cord-306904-8iteddug	484	3	of	of	IN
cord-306904-8iteddug	484	4	the	the	DT
cord-306904-8iteddug	484	5	broad	broad	RB
cord-306904-8iteddug	484	6	-	-	HYPH
cord-306904-8iteddug	484	7	functioning	function	VBG
cord-306904-8iteddug	484	8	tumor	tumor	NN
cord-306904-8iteddug	484	9	suppressor	suppressor	NN
cord-306904-8iteddug	484	10	retinoblastoma	retinoblastoma	NN
cord-306904-8iteddug	484	11	protein	protein	NN
cord-306904-8iteddug	484	12	(	(	-LRB-
cord-306904-8iteddug	484	13	Rb	Rb	NNP
cord-306904-8iteddug	484	14	)	)	-RRB-
cord-306904-8iteddug	484	15	is	be	VBZ
cord-306904-8iteddug	484	16	associated	associate	VBN
cord-306904-8iteddug	484	17	with	with	IN
cord-306904-8iteddug	484	18	several	several	JJ
cord-306904-8iteddug	484	19	human	human	JJ
cord-306904-8iteddug	484	20	cancers	cancer	NNS
cord-306904-8iteddug	484	21	.	.	.
cord-306904-8iteddug	485	1	180	180	CD
cord-306904-8iteddug	485	2	,	,	,
cord-306904-8iteddug	485	3	181	181	CD
cord-306904-8iteddug	486	1	Among	among	IN
cord-306904-8iteddug	486	2	numerous	numerous	JJ
cord-306904-8iteddug	486	3	functions	function	NNS
cord-306904-8iteddug	486	4	ascribed	ascribe	VBN
cord-306904-8iteddug	486	5	to	to	IN
cord-306904-8iteddug	486	6	this	this	DT
cord-306904-8iteddug	486	7	important	important	JJ
cord-306904-8iteddug	486	8	protein	protein	NN
cord-306904-8iteddug	486	9	is	be	VBZ
cord-306904-8iteddug	486	10	a	a	DT
cord-306904-8iteddug	486	11	negative	negative	JJ
cord-306904-8iteddug	486	12	regulation	regulation	NN
cord-306904-8iteddug	486	13	of	of	IN
cord-306904-8iteddug	486	14	cell	cell	NN
cord-306904-8iteddug	486	15	division	division	NN
cord-306904-8iteddug	486	16	at	at	IN
cord-306904-8iteddug	486	17	the	the	DT
cord-306904-8iteddug	486	18	G	g	NN
cord-306904-8iteddug	486	19	1	1	CD
cord-306904-8iteddug	486	20	-S	-S	HYPH
cord-306904-8iteddug	486	21	transition	transition	NN
cord-306904-8iteddug	486	22	of	of	IN
cord-306904-8iteddug	486	23	the	the	DT
cord-306904-8iteddug	486	24	cell	cell	NN
cord-306904-8iteddug	486	25	cycle	cycle	NN
cord-306904-8iteddug	486	26	,	,	,
cord-306904-8iteddug	486	27	182	182	CD
cord-306904-8iteddug	486	28	where	where	WRB
cord-306904-8iteddug	486	29	Rb	Rb	NNP
cord-306904-8iteddug	486	30	forms	form	VBZ
cord-306904-8iteddug	486	31	a	a	DT
cord-306904-8iteddug	486	32	growth	growth	NN
cord-306904-8iteddug	486	33	-	-	HYPH
cord-306904-8iteddug	486	34	repressive	repressive	JJ
cord-306904-8iteddug	486	35	complex	complex	NN
cord-306904-8iteddug	486	36	with	with	IN
cord-306904-8iteddug	486	37	E2F	e2f	NN
cord-306904-8iteddug	486	38	transcription	transcription	NN
cord-306904-8iteddug	486	39	factors	factor	NNS
cord-306904-8iteddug	486	40	183	183	CD
cord-306904-8iteddug	486	41	in	in	IN
cord-306904-8iteddug	486	42	a	a	DT
cord-306904-8iteddug	486	43	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	486	44	-	-	HYPH
cord-306904-8iteddug	486	45	dependent	dependent	JJ
cord-306904-8iteddug	486	46	manner	manner	NN
cord-306904-8iteddug	486	47	.	.	.
cord-306904-8iteddug	487	1	Burke	Burke	NNP
cord-306904-8iteddug	487	2	et	et	NNP
cord-306904-8iteddug	487	3	al	al	NNP
cord-306904-8iteddug	487	4	.	.	NNP
cord-306904-8iteddug	487	5	showed	show	VBD
cord-306904-8iteddug	487	6	that	that	IN
cord-306904-8iteddug	487	7	there	there	EX
cord-306904-8iteddug	487	8	are	be	VBP
cord-306904-8iteddug	487	9	at	at	IN
cord-306904-8iteddug	487	10	least	least	JJS
cord-306904-8iteddug	487	11	2	2	CD
cord-306904-8iteddug	487	12	different	different	JJ
cord-306904-8iteddug	487	13	mechanisms	mechanism	NNS
cord-306904-8iteddug	487	14	by	by	IN
cord-306904-8iteddug	487	15	which	which	WDT
cord-306904-8iteddug	487	16	RbC	rbc	NN
cord-306904-8iteddug	487	17	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	487	18	inhibits	inhibit	VBZ
cord-306904-8iteddug	487	19	E2F	e2f	NN
cord-306904-8iteddug	487	20	binding	bind	VBG
cord-306904-8iteddug	487	21	.	.	.
cord-306904-8iteddug	488	1	Here	here	RB
cord-306904-8iteddug	488	2	,	,	,
cord-306904-8iteddug	488	3	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	488	4	of	of	IN
cord-306904-8iteddug	488	5	S788	S788	NNPS
cord-306904-8iteddug	488	6	and	and	CC
cord-306904-8iteddug	488	7	S795	S795	NNS
cord-306904-8iteddug	488	8	weakens	weaken	VBZ
cord-306904-8iteddug	488	9	the	the	DT
cord-306904-8iteddug	488	10	direct	direct	JJ
cord-306904-8iteddug	488	11	association	association	NN
cord-306904-8iteddug	488	12	between	between	IN
cord-306904-8iteddug	488	13	the	the	DT
cord-306904-8iteddug	488	14	RbC	rbc	NN
cord-306904-8iteddug	488	15	and	and	CC
cord-306904-8iteddug	488	16	the	the	DT
cord-306904-8iteddug	488	17	marked	mark	VBN
cord-306904-8iteddug	488	18	-	-	HYPH
cord-306904-8iteddug	488	19	box	box	NN
cord-306904-8iteddug	488	20	domains	domain	NNS
cord-306904-8iteddug	488	21	of	of	IN
cord-306904-8iteddug	488	22	E2F	e2f	NN
cord-306904-8iteddug	488	23	,	,	,
cord-306904-8iteddug	488	24	whereas	whereas	IN
cord-306904-8iteddug	488	25	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	488	26	of	of	IN
cord-306904-8iteddug	488	27	S788	S788	NNPS
cord-306904-8iteddug	488	28	,	,	,
cord-306904-8iteddug	488	29	S795	S795	NNS
cord-306904-8iteddug	488	30	,	,	,
cord-306904-8iteddug	488	31	S807	S807	NNP
cord-306904-8iteddug	488	32	and	and	CC
cord-306904-8iteddug	488	33	S811	S811	NNP
cord-306904-8iteddug	488	34	induces	induce	VBZ
cord-306904-8iteddug	488	35	an	an	DT
cord-306904-8iteddug	488	36	intramolecular	intramolecular	JJ
cord-306904-8iteddug	488	37	association	association	NN
cord-306904-8iteddug	488	38	between	between	IN
cord-306904-8iteddug	488	39	RbC	RbC	NNP
cord-306904-8iteddug	488	40	and	and	CC
cord-306904-8iteddug	488	41	the	the	DT
cord-306904-8iteddug	488	42	pocket	pocket	NN
cord-306904-8iteddug	488	43	domain	domain	NN
cord-306904-8iteddug	488	44	,	,	,
cord-306904-8iteddug	488	45	which	which	WDT
cord-306904-8iteddug	488	46	overlaps	overlap	VBZ
cord-306904-8iteddug	488	47	with	with	IN
cord-306904-8iteddug	488	48	the	the	DT
cord-306904-8iteddug	488	49	site	site	NN
cord-306904-8iteddug	488	50	of	of	IN
cord-306904-8iteddug	488	51	E2F	E2F	NNP
cord-306904-8iteddug	488	52	transactivation	transactivation	NNP
cord-306904-8iteddug	488	53	domain	domain	NN
cord-306904-8iteddug	488	54	binding	bind	VBG
cord-306904-8iteddug	488	55	.	.	.
cord-306904-8iteddug	489	1	179	179	CD
cord-306904-8iteddug	489	2	Figure	figure	NN
cord-306904-8iteddug	489	3	14B	14b	NN
cord-306904-8iteddug	489	4	shows	show	VBZ
cord-306904-8iteddug	489	5	that	that	IN
cord-306904-8iteddug	489	6	human	human	JJ
cord-306904-8iteddug	489	7	retinoblastoma	retinoblastoma	NN
cord-306904-8iteddug	489	8	-	-	HYPH
cord-306904-8iteddug	489	9	associated	associate	VBN
cord-306904-8iteddug	489	10	protein	protein	NN
cord-306904-8iteddug	489	11	(	(	-LRB-
cord-306904-8iteddug	489	12	UniProt	UniProt	NNP
cord-306904-8iteddug	489	13	ID	ID	NNP
cord-306904-8iteddug	489	14	:	:	:
cord-306904-8iteddug	489	15	P06400	P06400	NNP
cord-306904-8iteddug	489	16	)	)	-RRB-
cord-306904-8iteddug	489	17	is	be	VBZ
cord-306904-8iteddug	489	18	predicted	predict	VBN
cord-306904-8iteddug	489	19	to	to	TO
cord-306904-8iteddug	489	20	have	have	VB
cord-306904-8iteddug	489	21	numerous	numerous	JJ
cord-306904-8iteddug	489	22	disordered	disordered	JJ
cord-306904-8iteddug	489	23	regions	region	NNS
cord-306904-8iteddug	489	24	,	,	,
cord-306904-8iteddug	489	25	including	include	VBG
cord-306904-8iteddug	489	26	long	long	JJ
cord-306904-8iteddug	489	27	disordered	disordered	JJ
cord-306904-8iteddug	489	28	tails	tail	NNS
cord-306904-8iteddug	489	29	.	.	.
cord-306904-8iteddug	490	1	The	the	DT
cord-306904-8iteddug	490	2	longest	long	RBS
cord-306904-8iteddug	490	3	disordered	disordered	JJ
cord-306904-8iteddug	490	4	region	region	NN
cord-306904-8iteddug	490	5	is	be	VBZ
cord-306904-8iteddug	490	6	the	the	DT
cord-306904-8iteddug	490	7	C	C	NNP
cord-306904-8iteddug	490	8	-	-	HYPH
cord-306904-8iteddug	490	9	terminal	terminal	NN
cord-306904-8iteddug	490	10	tail	tail	NN
cord-306904-8iteddug	490	11	(	(	-LRB-
cord-306904-8iteddug	490	12	residues	residue	VBZ
cord-306904-8iteddug	490	13	760	760	CD
cord-306904-8iteddug	490	14	-	-	HYPH
cord-306904-8iteddug	490	15	928	928	CD
cord-306904-8iteddug	490	16	)	)	-RRB-
cord-306904-8iteddug	490	17	that	that	WDT
cord-306904-8iteddug	490	18	contains	contain	VBZ
cord-306904-8iteddug	490	19	all	all	PDT
cord-306904-8iteddug	490	20	the	the	DT
cord-306904-8iteddug	490	21	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	490	22	sites	site	NNS
cord-306904-8iteddug	490	23	discussed	discuss	VBN
cord-306904-8iteddug	490	24	above	above	RB
cord-306904-8iteddug	490	25	.	.	.
cord-306904-8iteddug	491	1	According	accord	VBG
cord-306904-8iteddug	491	2	to	to	IN
cord-306904-8iteddug	491	3	the	the	DT
cord-306904-8iteddug	491	4	ANCHOR	ANCHOR	NNP
cord-306904-8iteddug	491	5	analysis	analysis	NN
cord-306904-8iteddug	491	6	,	,	,
cord-306904-8iteddug	491	7	15	15	CD
cord-306904-8iteddug	491	8	www.landesbioscience.com	www.landesbioscience.com	ADD
cord-306904-8iteddug	491	9	e970499	e970499	NNP
cord-306904-8iteddug	491	10	-	-	HYPH
cord-306904-8iteddug	491	11	23	23	CD
cord-306904-8iteddug	492	1	Intrinsically	intrinsically	RB
cord-306904-8iteddug	492	2	Disordered	disordered	JJ
cord-306904-8iteddug	492	3	Proteins	protein	NNS
cord-306904-8iteddug	492	4	are	be	VBP
cord-306904-8iteddug	492	5	typically	typically	RB
cord-306904-8iteddug	492	6	found	find	VBN
cord-306904-8iteddug	492	7	in	in	IN
cord-306904-8iteddug	492	8	regions	region	NNS
cord-306904-8iteddug	492	9	of	of	IN
cord-306904-8iteddug	492	10	intrinsic	intrinsic	JJ
cord-306904-8iteddug	492	11	disorder	disorder	NN
cord-306904-8iteddug	492	12	.	.	.
cord-306904-8iteddug	493	1	126	126	CD
cord-306904-8iteddug	493	2	,	,	,
cord-306904-8iteddug	493	3	174	174	CD
cord-306904-8iteddug	493	4	,	,	,
cord-306904-8iteddug	493	5	[	[	-LRB-
cord-306904-8iteddug	493	6	185	185	CD
cord-306904-8iteddug	493	7	]	]	-RRB-
cord-306904-8iteddug	493	8	[	[	-LRB-
cord-306904-8iteddug	493	9	186	186	CD
cord-306904-8iteddug	493	10	]	]	-RRB-
cord-306904-8iteddug	493	11	[	[	-LRB-
cord-306904-8iteddug	493	12	187	187	CD
cord-306904-8iteddug	493	13	]	]	-RRB-
cord-306904-8iteddug	494	1	The	the	DT
cord-306904-8iteddug	494	2	tetratricopeptide	tetratricopeptide	JJ
cord-306904-8iteddug	494	3	repeat	repeat	NN
cord-306904-8iteddug	494	4	(	(	-LRB-
cord-306904-8iteddug	494	5	TPR	TPR	NNP
cord-306904-8iteddug	494	6	)	)	-RRB-
cord-306904-8iteddug	494	7	motifcontaining	motifcontaine	VBG
cord-306904-8iteddug	494	8	protein	protein	NN
cord-306904-8iteddug	494	9	LGN	LGN	NNP
cord-306904-8iteddug	494	10	and	and	CC
cord-306904-8iteddug	494	11	its	-PRON-	PRP$
cord-306904-8iteddug	494	12	binding	bind	VBG
cord-306904-8iteddug	494	13	partner	partner	NN
cord-306904-8iteddug	494	14	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	495	1	(	(	-LRB-
cord-306904-8iteddug	495	2	FERM	FERM	NNP
cord-306904-8iteddug	495	3	and	and	CC
cord-306904-8iteddug	495	4	PDZ	PDZ	NNP
cord-306904-8iteddug	495	5	domain	domain	NN
cord-306904-8iteddug	495	6	containing	contain	VBG
cord-306904-8iteddug	495	7	1	1	CD
cord-306904-8iteddug	495	8	)	)	-RRB-
cord-306904-8iteddug	496	1	Pan	Pan	NNP
cord-306904-8iteddug	496	2	et	et	NNP
cord-306904-8iteddug	496	3	al	al	NNP
cord-306904-8iteddug	496	4	.	.	.
cord-306904-8iteddug	497	1	described	describe	VBD
cord-306904-8iteddug	497	2	structural	structural	JJ
cord-306904-8iteddug	497	3	peculiarities	peculiarity	NNS
cord-306904-8iteddug	497	4	of	of	IN
cord-306904-8iteddug	497	5	the	the	DT
cord-306904-8iteddug	497	6	human	human	JJ
cord-306904-8iteddug	497	7	LGN	LGN	NNP
cord-306904-8iteddug	497	8	-	-	HYPH
cord-306904-8iteddug	497	9	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	497	10	complex	complex	NN
cord-306904-8iteddug	497	11	.	.	.
cord-306904-8iteddug	498	1	188	188	CD
cord-306904-8iteddug	499	1	To	to	IN
cord-306904-8iteddug	499	2	this	this	DT
cord-306904-8iteddug	499	3	end	end	NN
cord-306904-8iteddug	499	4	,	,	,
cord-306904-8iteddug	499	5	a	a	DT
cord-306904-8iteddug	499	6	crystal	crystal	NN
cord-306904-8iteddug	499	7	structure	structure	NN
cord-306904-8iteddug	499	8	of	of	IN
cord-306904-8iteddug	499	9	the	the	DT
cord-306904-8iteddug	499	10	complex	complex	NN
cord-306904-8iteddug	499	11	between	between	IN
cord-306904-8iteddug	499	12	the	the	DT
cord-306904-8iteddug	499	13	15	15	CD
cord-306904-8iteddug	499	14	-	-	SYM
cord-306904-8iteddug	499	15	350	350	CD
cord-306904-8iteddug	499	16	fragment	fragment	NN
cord-306904-8iteddug	499	17	of	of	IN
cord-306904-8iteddug	499	18	human	human	JJ
cord-306904-8iteddug	499	19	LGN	LGN	NNP
cord-306904-8iteddug	499	20	containing	contain	VBG
cord-306904-8iteddug	499	21	8	8	CD
cord-306904-8iteddug	499	22	tetratricopeptide	tetratricopeptide	JJ
cord-306904-8iteddug	499	23	repeat	repeat	NN
cord-306904-8iteddug	499	24	motifs	motif	NNS
cord-306904-8iteddug	499	25	(	(	-LRB-
cord-306904-8iteddug	499	26	UniProt	UniProt	NNP
cord-306904-8iteddug	499	27	ID	ID	NNP
cord-306904-8iteddug	499	28	:	:	:
cord-306904-8iteddug	499	29	P81274	P81274	NNP
cord-306904-8iteddug	499	30	)	)	-RRB-
cord-306904-8iteddug	499	31	and	and	CC
cord-306904-8iteddug	499	32	the	the	DT
cord-306904-8iteddug	499	33	901	901	CD
cord-306904-8iteddug	499	34	-	-	SYM
cord-306904-8iteddug	499	35	951	951	CD
cord-306904-8iteddug	499	36	fragment	fragment	NN
cord-306904-8iteddug	499	37	of	of	IN
cord-306904-8iteddug	499	38	human	human	JJ
cord-306904-8iteddug	499	39	Frmdp1	Frmdp1	NNP
cord-306904-8iteddug	500	1	(	(	-LRB-
cord-306904-8iteddug	500	2	UniProt	UniProt	NNP
cord-306904-8iteddug	500	3	ID	ID	NNP
cord-306904-8iteddug	500	4	:	:	:
cord-306904-8iteddug	501	1	Q5SYB0	Q5SYB0	NNP
cord-306904-8iteddug	501	2	)	)	-RRB-
cord-306904-8iteddug	501	3	was	be	VBD
cord-306904-8iteddug	501	4	solved	solve	VBN
cord-306904-8iteddug	501	5	at	at	IN
cord-306904-8iteddug	501	6	2.4	2.4	CD
cord-306904-8iteddug	501	7	A	a	DT
cord-306904-8iteddug	501	8	resolution	resolution	NN
cord-306904-8iteddug	501	9	.	.	.
cord-306904-8iteddug	502	1	188	188	CD
cord-306904-8iteddug	503	1	In	in	IN
cord-306904-8iteddug	503	2	this	this	DT
cord-306904-8iteddug	503	3	LGN	LGN	NNP
cord-306904-8iteddug	503	4	-	-	HYPH
cord-306904-8iteddug	503	5	TPR	TPR	NNP
cord-306904-8iteddug	503	6	/	/	SYM
cord-306904-8iteddug	503	7	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	503	8	complex	complex	NN
cord-306904-8iteddug	503	9	,	,	,
cord-306904-8iteddug	503	10	almost	almost	RB
cord-306904-8iteddug	503	11	the	the	DT
cord-306904-8iteddug	503	12	entire	entire	JJ
cord-306904-8iteddug	503	13	length	length	NN
cord-306904-8iteddug	503	14	of	of	IN
cord-306904-8iteddug	503	15	LGN	LGN	NNP
cord-306904-8iteddug	503	16	-	-	HYPH
cord-306904-8iteddug	503	17	TPR	TPR	NNP
cord-306904-8iteddug	503	18	was	be	VBD
cord-306904-8iteddug	503	19	well	well	RB
cord-306904-8iteddug	503	20	resolved	resolve	VBN
cord-306904-8iteddug	503	21	,	,	,
cord-306904-8iteddug	503	22	and	and	CC
cord-306904-8iteddug	503	23	most	most	JJS
cord-306904-8iteddug	503	24	residues	residue	NNS
cord-306904-8iteddug	503	25	of	of	IN
cord-306904-8iteddug	503	26	the	the	DT
cord-306904-8iteddug	503	27	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	503	28	fragment	fragment	NN
cord-306904-8iteddug	503	29	were	be	VBD
cord-306904-8iteddug	503	30	clearly	clearly	RB
cord-306904-8iteddug	503	31	resolved	resolve	VBN
cord-306904-8iteddug	503	32	adopting	adopt	VBG
cord-306904-8iteddug	503	33	an	an	DT
cord-306904-8iteddug	503	34	extended	extended	JJ
cord-306904-8iteddug	503	35	conformation	conformation	NN
cord-306904-8iteddug	503	36	that	that	WDT
cord-306904-8iteddug	503	37	occupied	occupy	VBD
cord-306904-8iteddug	503	38	most	most	JJS
cord-306904-8iteddug	503	39	of	of	IN
cord-306904-8iteddug	503	40	the	the	DT
cord-306904-8iteddug	503	41	concave	concave	JJ
cord-306904-8iteddug	503	42	channel	channel	NN
cord-306904-8iteddug	503	43	formed	form	VBN
cord-306904-8iteddug	503	44	by	by	IN
cord-306904-8iteddug	503	45	the	the	DT
cord-306904-8iteddug	503	46	8	8	CD
cord-306904-8iteddug	503	47	TPR	TPR	NNP
cord-306904-8iteddug	503	48	motifs	motif	NNS
cord-306904-8iteddug	503	49	and	and	CC
cord-306904-8iteddug	503	50	buried	bury	VBD
cord-306904-8iteddug	503	51	a	a	DT
cord-306904-8iteddug	503	52	total	total	NN
cord-306904-8iteddug	503	53	of	of	IN
cord-306904-8iteddug	503	54	2541	2541	CD
cord-306904-8iteddug	503	55	A	a	DT
cord-306904-8iteddug	503	56	2	2	CD
cord-306904-8iteddug	503	57	surface	surface	NN
cord-306904-8iteddug	503	58	area	area	NN
cord-306904-8iteddug	503	59	.	.	.
cord-306904-8iteddug	504	1	188	188	CD
cord-306904-8iteddug	505	1	The	the	DT
cord-306904-8iteddug	505	2	noticeable	noticeable	JJ
cord-306904-8iteddug	505	3	exceptions	exception	NNS
cord-306904-8iteddug	505	4	were	be	VBD
cord-306904-8iteddug	505	5	the	the	DT
cord-306904-8iteddug	505	6	11	11	CD
cord-306904-8iteddug	505	7	residues	residue	NNS
cord-306904-8iteddug	505	8	in	in	IN
cord-306904-8iteddug	505	9	the	the	DT
cord-306904-8iteddug	505	10	loop	loop	NN
cord-306904-8iteddug	505	11	connecting	connect	VBG
cord-306904-8iteddug	505	12	the	the	DT
cord-306904-8iteddug	505	13	aA	aa	NN
cord-306904-8iteddug	505	14	and	and	CC
cord-306904-8iteddug	505	15	aB	ab	NN
cord-306904-8iteddug	505	16	of	of	IN
cord-306904-8iteddug	505	17	TPR3	TPR3	NNP
cord-306904-8iteddug	505	18	(	(	-LRB-
cord-306904-8iteddug	505	19	amino	amino	NN
cord-306904-8iteddug	505	20	acids	acid	NNS
cord-306904-8iteddug	506	1	153	153	CD
cord-306904-8iteddug	506	2	-	-	SYM
cord-306904-8iteddug	506	3	163	163	CD
cord-306904-8iteddug	506	4	)	)	-RRB-
cord-306904-8iteddug	507	1	and	and	CC
cord-306904-8iteddug	507	2	the	the	DT
cord-306904-8iteddug	507	3	6	6	CD
cord-306904-8iteddug	507	4	residues	residue	NNS
cord-306904-8iteddug	507	5	at	at	IN
cord-306904-8iteddug	507	6	the	the	DT
cord-306904-8iteddug	507	7	C	C	NNP
cord-306904-8iteddug	507	8	terminus	terminus	NN
cord-306904-8iteddug	507	9	(	(	-LRB-
cord-306904-8iteddug	507	10	amino	amino	JJ
cord-306904-8iteddug	507	11	acids	acid	NNS
cord-306904-8iteddug	507	12	345	345	CD
cord-306904-8iteddug	507	13	-	-	SYM
cord-306904-8iteddug	507	14	350	350	CD
cord-306904-8iteddug	507	15	)	)	-RRB-
cord-306904-8iteddug	507	16	in	in	IN
cord-306904-8iteddug	507	17	the	the	DT
cord-306904-8iteddug	507	18	LGN	LGN	NNP
cord-306904-8iteddug	507	19	-	-	HYPH
cord-306904-8iteddug	507	20	TPR	TPR	NNP
cord-306904-8iteddug	507	21	,	,	,
cord-306904-8iteddug	507	22	and	and	CC
cord-306904-8iteddug	507	23	the	the	DT
cord-306904-8iteddug	507	24	Nterminal	Nterminal	NNP
cord-306904-8iteddug	507	25	8	8	CD
cord-306904-8iteddug	507	26	residues	residue	NNS
cord-306904-8iteddug	507	27	(	(	-LRB-
cord-306904-8iteddug	507	28	amino	amino	JJ
cord-306904-8iteddug	507	29	acids	acid	NNS
cord-306904-8iteddug	507	30	912	912	CD
cord-306904-8iteddug	507	31	-	-	HYPH
cord-306904-8iteddug	507	32	919	919	CD
cord-306904-8iteddug	507	33	)	)	-RRB-
cord-306904-8iteddug	507	34	and	and	CC
cord-306904-8iteddug	507	35	the	the	DT
cord-306904-8iteddug	507	36	last	last	JJ
cord-306904-8iteddug	507	37	2	2	CD
cord-306904-8iteddug	507	38	residues	residue	NNS
cord-306904-8iteddug	507	39	at	at	IN
cord-306904-8iteddug	507	40	the	the	DT
cord-306904-8iteddug	507	41	C	C	NNP
cord-306904-8iteddug	507	42	terminus	terminus	NN
cord-306904-8iteddug	507	43	(	(	-LRB-
cord-306904-8iteddug	507	44	amino	amino	JJ
cord-306904-8iteddug	507	45	acids	acid	NNS
cord-306904-8iteddug	507	46	937	937	CD
cord-306904-8iteddug	507	47	-	-	SYM
cord-306904-8iteddug	507	48	938	938	CD
cord-306904-8iteddug	507	49	)	)	-RRB-
cord-306904-8iteddug	507	50	of	of	IN
cord-306904-8iteddug	507	51	the	the	DT
cord-306904-8iteddug	507	52	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	507	53	fragment	fragment	NN
cord-306904-8iteddug	507	54	,	,	,
cord-306904-8iteddug	507	55	all	all	DT
cord-306904-8iteddug	507	56	of	of	IN
cord-306904-8iteddug	507	57	which	which	WDT
cord-306904-8iteddug	507	58	were	be	VBD
cord-306904-8iteddug	507	59	missing	miss	VBG
cord-306904-8iteddug	507	60	in	in	IN
cord-306904-8iteddug	507	61	the	the	DT
cord-306904-8iteddug	507	62	structure	structure	NN
cord-306904-8iteddug	507	63	of	of	IN
cord-306904-8iteddug	507	64	the	the	DT
cord-306904-8iteddug	507	65	LGN	LGN	NNP
cord-306904-8iteddug	507	66	-	-	HYPH
cord-306904-8iteddug	507	67	TPR	TPR	NNP
cord-306904-8iteddug	507	68	/	/	SYM
cord-306904-8iteddug	507	69	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	507	70	complex	complex	NN
cord-306904-8iteddug	507	71	.	.	.
cord-306904-8iteddug	508	1	188	188	CD
cord-306904-8iteddug	508	2	Leu	Leu	NNP
cord-306904-8iteddug	508	3	-	-	HYPH
cord-306904-8iteddug	508	4	Gly	Gly	NNP
cord-306904-8iteddug	508	5	-	-	HYPH
cord-306904-8iteddug	508	6	Asn	Asn	NNP
cord-306904-8iteddug	508	7	repeatenriched	repeatenriche	VBD
cord-306904-8iteddug	508	8	protein	protein	NN
cord-306904-8iteddug	508	9	LGN/	LGN/	NNP
cord-306904-8iteddug	508	10	AGS3	AGS3	NNPS
cord-306904-8iteddug	508	11	in	in	IN
cord-306904-8iteddug	508	12	mammals	mammal	NNS
cord-306904-8iteddug	508	13	(	(	-LRB-
cord-306904-8iteddug	508	14	Pins	pin	NNS
cord-306904-8iteddug	508	15	,	,	,
cord-306904-8iteddug	508	16	or	or	CC
cord-306904-8iteddug	508	17	partner	partner	NN
cord-306904-8iteddug	508	18	of	of	IN
cord-306904-8iteddug	508	19	inscuteable	inscuteable	JJ
cord-306904-8iteddug	508	20	in	in	IN
cord-306904-8iteddug	508	21	Drosophila	Drosophila	NNP
cord-306904-8iteddug	508	22	neuroblasts	neuroblast	NNS
cord-306904-8iteddug	508	23	)	)	-RRB-
cord-306904-8iteddug	508	24	plays	play	VBZ
cord-306904-8iteddug	508	25	a	a	DT
cord-306904-8iteddug	508	26	number	number	NN
cord-306904-8iteddug	508	27	of	of	IN
cord-306904-8iteddug	508	28	crucial	crucial	JJ
cord-306904-8iteddug	508	29	roles	role	NNS
cord-306904-8iteddug	508	30	in	in	IN
cord-306904-8iteddug	508	31	regulation	regulation	NN
cord-306904-8iteddug	508	32	of	of	IN
cord-306904-8iteddug	508	33	cell	cell	NN
cord-306904-8iteddug	508	34	polarity	polarity	NN
cord-306904-8iteddug	508	35	and	and	CC
cord-306904-8iteddug	508	36	spindle	spindle	NN
cord-306904-8iteddug	508	37	orientation	orientation	NN
cord-306904-8iteddug	508	38	during	during	IN
cord-306904-8iteddug	508	39	cellular	cellular	JJ
cord-306904-8iteddug	508	40	differentiation	differentiation	NN
cord-306904-8iteddug	508	41	and	and	CC
cord-306904-8iteddug	508	42	self	self	NN
cord-306904-8iteddug	508	43	-	-	HYPH
cord-306904-8iteddug	508	44	renewal	renewal	NN
cord-306904-8iteddug	508	45	in	in	IN
cord-306904-8iteddug	508	46	multicellular	multicellular	JJ
cord-306904-8iteddug	508	47	eukaryotes	eukaryote	NNS
cord-306904-8iteddug	508	48	development	development	NN
cord-306904-8iteddug	508	49	.	.	.
cord-306904-8iteddug	509	1	[	[	-LRB-
cord-306904-8iteddug	509	2	189	189	CD
cord-306904-8iteddug	509	3	]	]	-RRB-
cord-306904-8iteddug	509	4	[	[	-LRB-
cord-306904-8iteddug	509	5	190	190	CD
cord-306904-8iteddug	509	6	]	]	-RRB-
cord-306904-8iteddug	509	7	[	[	-LRB-
cord-306904-8iteddug	509	8	191	191	CD
cord-306904-8iteddug	509	9	]	]	-RRB-
cord-306904-8iteddug	510	1	Structurally	structurally	RB
cord-306904-8iteddug	510	2	,	,	,
cord-306904-8iteddug	510	3	LGN	LGN	NNP
cord-306904-8iteddug	510	4	consist	consist	VBP
cord-306904-8iteddug	510	5	of	of	IN
cord-306904-8iteddug	510	6	8	8	CD
cord-306904-8iteddug	510	7	tetratricopeptide	tetratricopeptide	JJ
cord-306904-8iteddug	510	8	repeat	repeat	NN
cord-306904-8iteddug	510	9	(	(	-LRB-
cord-306904-8iteddug	510	10	TPR	TPR	NNP
cord-306904-8iteddug	510	11	)	)	-RRB-
cord-306904-8iteddug	510	12	motifs	motif	NNS
cord-306904-8iteddug	510	13	in	in	IN
cord-306904-8iteddug	510	14	its	-PRON-	PRP$
cord-306904-8iteddug	510	15	N	n	CD
cord-306904-8iteddug	510	16	-	-	HYPH
cord-306904-8iteddug	510	17	terminal	terminal	JJ
cord-306904-8iteddug	510	18	half	half	NN
cord-306904-8iteddug	510	19	and	and	CC
cord-306904-8iteddug	510	20	3	3	CD
cord-306904-8iteddug	510	21	or	or	CC
cord-306904-8iteddug	510	22	4	4	CD
cord-306904-8iteddug	510	23	GoLoco	GoLoco	NNP
cord-306904-8iteddug	510	24	motifs	motif	NNS
cord-306904-8iteddug	510	25	(	(	-LRB-
cord-306904-8iteddug	510	26	also	also	RB
cord-306904-8iteddug	510	27	referred	refer	VBN
cord-306904-8iteddug	510	28	to	to	IN
cord-306904-8iteddug	510	29	as	as	IN
cord-306904-8iteddug	510	30	G	g	NN
cord-306904-8iteddug	510	31	-	-	HYPH
cord-306904-8iteddug	510	32	protein	protein	NN
cord-306904-8iteddug	510	33	regulatory	regulatory	JJ
cord-306904-8iteddug	510	34	or	or	CC
cord-306904-8iteddug	510	35	GPR	GPR	NNP
cord-306904-8iteddug	510	36	motifs	motif	NNS
cord-306904-8iteddug	510	37	)	)	-RRB-
cord-306904-8iteddug	510	38	in	in	IN
cord-306904-8iteddug	510	39	the	the	DT
cord-306904-8iteddug	510	40	C	C	NNP
cord-306904-8iteddug	510	41	-	-	HYPH
cord-306904-8iteddug	510	42	terminal	terminal	NN
cord-306904-8iteddug	510	43	half	half	NN
cord-306904-8iteddug	510	44	.	.	.
cord-306904-8iteddug	511	1	[	[	-LRB-
cord-306904-8iteddug	511	2	192	192	CD
cord-306904-8iteddug	511	3	]	]	-RRB-
cord-306904-8iteddug	511	4	[	[	-LRB-
cord-306904-8iteddug	511	5	193	193	CD
cord-306904-8iteddug	511	6	]	]	-RRB-
cord-306904-8iteddug	512	1	[	[	-LRB-
cord-306904-8iteddug	512	2	194	194	CD
cord-306904-8iteddug	512	3	]	]	-RRB-
cord-306904-8iteddug	512	4	Both	both	DT
cord-306904-8iteddug	512	5	of	of	IN
cord-306904-8iteddug	512	6	these	these	DT
cord-306904-8iteddug	512	7	motifs	motif	NNS
cord-306904-8iteddug	512	8	are	be	VBP
cord-306904-8iteddug	512	9	crucial	crucial	JJ
cord-306904-8iteddug	512	10	for	for	IN
cord-306904-8iteddug	512	11	protein	protein	NN
cord-306904-8iteddug	512	12	-	-	HYPH
cord-306904-8iteddug	512	13	protein	protein	NN
cord-306904-8iteddug	512	14	interactions	interaction	NNS
cord-306904-8iteddug	512	15	,	,	,
cord-306904-8iteddug	512	16	195	195	CD
cord-306904-8iteddug	512	17	,	,	,
cord-306904-8iteddug	512	18	196	196	CD
cord-306904-8iteddug	512	19	with	with	IN
cord-306904-8iteddug	512	20	each	each	DT
cord-306904-8iteddug	512	21	GoLoco	GoLoco	NNP
cord-306904-8iteddug	512	22	motif	motif	NN
cord-306904-8iteddug	512	23	of	of	IN
cord-306904-8iteddug	512	24	Pins	Pins	NNP
cord-306904-8iteddug	512	25	/	/	SYM
cord-306904-8iteddug	512	26	LGN	LGN	NNP
cord-306904-8iteddug	512	27	being	be	VBG
cord-306904-8iteddug	512	28	capable	capable	JJ
cord-306904-8iteddug	512	29	of	of	IN
cord-306904-8iteddug	512	30	binding	bind	VBG
cord-306904-8iteddug	512	31	to	to	IN
cord-306904-8iteddug	512	32	GDP	gdp	NN
cord-306904-8iteddug	512	33	-	-	HYPH
cord-306904-8iteddug	512	34	bound	bind	VBN
cord-306904-8iteddug	512	35	Gai	Gai	NNP
cord-306904-8iteddug	512	36	197	197	CD
cord-306904-8iteddug	512	37	leading	lead	VBG
cord-306904-8iteddug	512	38	to	to	IN
cord-306904-8iteddug	512	39	stable	stable	JJ
cord-306904-8iteddug	512	40	cortical	cortical	JJ
cord-306904-8iteddug	512	41	localization	localization	NN
cord-306904-8iteddug	512	42	of	of	IN
cord-306904-8iteddug	512	43	Pins	Pins	NNP
cord-306904-8iteddug	512	44	/	/	SYM
cord-306904-8iteddug	512	45	LGN	LGN	NNP
cord-306904-8iteddug	512	46	,	,	,
cord-306904-8iteddug	512	47	198	198	CD
cord-306904-8iteddug	512	48	and	and	CC
cord-306904-8iteddug	512	49	with	with	IN
cord-306904-8iteddug	512	50	the	the	DT
cord-306904-8iteddug	512	51	TPR	TPR	NNP
cord-306904-8iteddug	512	52	motifs	motif	NNS
cord-306904-8iteddug	512	53	possessing	possess	VBG
cord-306904-8iteddug	512	54	multiple	multiple	JJ
cord-306904-8iteddug	512	55	binding	bind	VBG
cord-306904-8iteddug	512	56	partners	partner	NNS
cord-306904-8iteddug	512	57	.	.	.
cord-306904-8iteddug	513	1	The	the	DT
cord-306904-8iteddug	513	2	canonical	canonical	JJ
cord-306904-8iteddug	513	3	TPR	TPR	NNP
cord-306904-8iteddug	513	4	motif	motif	NN
cord-306904-8iteddug	513	5	is	be	VBZ
cord-306904-8iteddug	513	6	a	a	DT
cord-306904-8iteddug	513	7	34-amino	34-amino	CD
cord-306904-8iteddug	513	8	-	-	HYPH
cord-306904-8iteddug	513	9	acid	acid	NN
cord-306904-8iteddug	513	10	protein	protein	NN
cord-306904-8iteddug	513	11	-	-	HYPH
cord-306904-8iteddug	513	12	protein	protein	NN
cord-306904-8iteddug	513	13	interaction	interaction	NN
cord-306904-8iteddug	513	14	module	module	NN
cord-306904-8iteddug	513	15	multiple	multiple	JJ
cord-306904-8iteddug	513	16	copies	copy	NNS
cord-306904-8iteddug	513	17	of	of	IN
cord-306904-8iteddug	513	18	are	be	VBP
cord-306904-8iteddug	513	19	found	find	VBN
cord-306904-8iteddug	513	20	in	in	IN
cord-306904-8iteddug	513	21	a	a	DT
cord-306904-8iteddug	513	22	wide	wide	JJ
cord-306904-8iteddug	513	23	range	range	NN
cord-306904-8iteddug	513	24	of	of	IN
cord-306904-8iteddug	513	25	proteins	protein	NNS
cord-306904-8iteddug	513	26	with	with	IN
cord-306904-8iteddug	513	27	diverse	diverse	JJ
cord-306904-8iteddug	513	28	functions	function	NNS
cord-306904-8iteddug	513	29	such	such	JJ
cord-306904-8iteddug	513	30	as	as	IN
cord-306904-8iteddug	513	31	cell	cell	NN
cord-306904-8iteddug	513	32	cycle	cycle	NN
cord-306904-8iteddug	513	33	regulations	regulation	NNS
cord-306904-8iteddug	513	34	,	,	,
cord-306904-8iteddug	513	35	gene	gene	NN
cord-306904-8iteddug	513	36	transcription	transcription	NN
cord-306904-8iteddug	513	37	and	and	CC
cord-306904-8iteddug	513	38	splicing	splicing	NN
cord-306904-8iteddug	513	39	processes	process	NNS
cord-306904-8iteddug	513	40	,	,	,
cord-306904-8iteddug	513	41	protein	protein	NN
cord-306904-8iteddug	513	42	trafficking	trafficking	NN
cord-306904-8iteddug	513	43	,	,	,
cord-306904-8iteddug	513	44	and	and	CC
cord-306904-8iteddug	513	45	protein	protein	NN
cord-306904-8iteddug	513	46	folding	folding	NN
cord-306904-8iteddug	513	47	.	.	.
cord-306904-8iteddug	514	1	195	195	CD
cord-306904-8iteddug	514	2	,	,	,
cord-306904-8iteddug	514	3	199	199	CD
cord-306904-8iteddug	514	4	Figure	figure	NN
cord-306904-8iteddug	514	5	15A	15a	NN
cord-306904-8iteddug	514	6	shows	show	VBZ
cord-306904-8iteddug	514	7	that	that	IN
cord-306904-8iteddug	514	8	human	human	JJ
cord-306904-8iteddug	514	9	LGN	LGN	NNP
cord-306904-8iteddug	514	10	protein	protein	NN
cord-306904-8iteddug	514	11	is	be	VBZ
cord-306904-8iteddug	514	12	involved	involve	VBN
cord-306904-8iteddug	514	13	in	in	IN
cord-306904-8iteddug	514	14	a	a	DT
cord-306904-8iteddug	514	15	wide	wide	JJ
cord-306904-8iteddug	514	16	range	range	NN
cord-306904-8iteddug	514	17	of	of	IN
cord-306904-8iteddug	514	18	protein	protein	NN
cord-306904-8iteddug	514	19	-	-	HYPH
cord-306904-8iteddug	514	20	protein	protein	NN
cord-306904-8iteddug	514	21	interactions	interaction	NNS
cord-306904-8iteddug	514	22	,	,	,
cord-306904-8iteddug	514	23	clearly	clearly	RB
cord-306904-8iteddug	514	24	serving	serve	VBG
cord-306904-8iteddug	514	25	as	as	IN
cord-306904-8iteddug	514	26	an	an	DT
cord-306904-8iteddug	514	27	important	important	JJ
cord-306904-8iteddug	514	28	hub	hub	NN
cord-306904-8iteddug	514	29	protein	protein	NN
cord-306904-8iteddug	514	30	.	.	.
cord-306904-8iteddug	515	1	This	this	DT
cord-306904-8iteddug	515	2	interactivity	interactivity	NN
cord-306904-8iteddug	515	3	analysis	analysis	NN
cord-306904-8iteddug	515	4	is	be	VBZ
cord-306904-8iteddug	515	5	done	do	VBN
cord-306904-8iteddug	515	6	by	by	IN
cord-306904-8iteddug	515	7	STRING	string	NN
cord-306904-8iteddug	515	8	.	.	.
cord-306904-8iteddug	516	1	59	59	CD
cord-306904-8iteddug	516	2	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	516	3	protein	protein	NN
cord-306904-8iteddug	516	4	(	(	-LRB-
cord-306904-8iteddug	516	5	FERM	FERM	NNP
cord-306904-8iteddug	516	6	and	and	CC
cord-306904-8iteddug	516	7	PDZ	PDZ	NNP
cord-306904-8iteddug	516	8	domain	domain	NN
cord-306904-8iteddug	516	9	containing	contain	VBG
cord-306904-8iteddug	516	10	1	1	CD
cord-306904-8iteddug	516	11	)	)	-RRB-
cord-306904-8iteddug	516	12	is	be	VBZ
cord-306904-8iteddug	516	13	known	know	VBN
cord-306904-8iteddug	516	14	to	to	TO
cord-306904-8iteddug	516	15	serve	serve	VB
cord-306904-8iteddug	516	16	as	as	IN
cord-306904-8iteddug	516	17	a	a	DT
cord-306904-8iteddug	516	18	regulatory	regulatory	JJ
cord-306904-8iteddug	516	19	binding	binding	NN
cord-306904-8iteddug	516	20	partner	partner	NN
cord-306904-8iteddug	516	21	of	of	IN
cord-306904-8iteddug	516	22	AGS3	AGS3	NNP
cord-306904-8iteddug	516	23	,	,	,
cord-306904-8iteddug	516	24	with	with	IN
cord-306904-8iteddug	516	25	a	a	DT
cord-306904-8iteddug	516	26	short	short	JJ
cord-306904-8iteddug	516	27	fragment	fragment	NN
cord-306904-8iteddug	516	28	of	of	IN
cord-306904-8iteddug	516	29	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	517	1	(	(	-LRB-
cord-306904-8iteddug	517	2	amino	amino	JJ
cord-306904-8iteddug	517	3	acids	acid	NNS
cord-306904-8iteddug	517	4	901	901	CD
cord-306904-8iteddug	517	5	-	-	SYM
cord-306904-8iteddug	517	6	938	938	CD
cord-306904-8iteddug	517	7	)	)	-RRB-
cord-306904-8iteddug	517	8	being	be	VBG
cord-306904-8iteddug	517	9	shown	show	VBN
cord-306904-8iteddug	517	10	to	to	TO
cord-306904-8iteddug	517	11	bind	bind	VB
cord-306904-8iteddug	517	12	to	to	IN
cord-306904-8iteddug	517	13	the	the	DT
cord-306904-8iteddug	517	14	8	8	CD
cord-306904-8iteddug	517	15	TPR	TPR	NNP
cord-306904-8iteddug	517	16	motifs	motif	NNS
cord-306904-8iteddug	517	17	of	of	IN
cord-306904-8iteddug	517	18	AGS3	AGS3	NNP
cord-306904-8iteddug	517	19	.	.	.
cord-306904-8iteddug	518	1	200	200	CD
cord-306904-8iteddug	518	2	Also	also	RB
cord-306904-8iteddug	518	3	,	,	,
cord-306904-8iteddug	518	4	a	a	DT
cord-306904-8iteddug	518	5	50residue	50residue	JJ
cord-306904-8iteddug	518	6	fragment	fragment	NN
cord-306904-8iteddug	518	7	(	(	-LRB-
cord-306904-8iteddug	518	8	amino	amino	JJ
cord-306904-8iteddug	518	9	acids	acid	NNS
cord-306904-8iteddug	518	10	901	901	CD
cord-306904-8iteddug	518	11	-	-	SYM
cord-306904-8iteddug	518	12	951	951	CD
cord-306904-8iteddug	518	13	)	)	-RRB-
cord-306904-8iteddug	518	14	of	of	IN
cord-306904-8iteddug	518	15	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	518	16	was	be	VBD
cord-306904-8iteddug	518	17	shown	show	VBN
cord-306904-8iteddug	518	18	to	to	TO
cord-306904-8iteddug	518	19	bind	bind	VB
cord-306904-8iteddug	518	20	to	to	IN
cord-306904-8iteddug	518	21	LGN	LGN	NNP
cord-306904-8iteddug	518	22	with	with	IN
cord-306904-8iteddug	518	23	a	a	DT
cord-306904-8iteddug	518	24	K	k	NN
cord-306904-8iteddug	518	25	d	d	NN
cord-306904-8iteddug	518	26	»	»	NN
cord-306904-8iteddug	518	27	1	1	CD
cord-306904-8iteddug	518	28	mM.	mm.	NN
cord-306904-8iteddug	518	29	188	188	CD
cord-306904-8iteddug	518	30	,	,	,
cord-306904-8iteddug	518	31	194	194	CD
cord-306904-8iteddug	518	32	Curiously	curiously	RB
cord-306904-8iteddug	518	33	,	,	,
cord-306904-8iteddug	518	34	besides	besides	IN
cord-306904-8iteddug	518	35	the	the	DT
cord-306904-8iteddug	518	36	mentioned	mention	VBN
cord-306904-8iteddug	518	37	above	above	IN
cord-306904-8iteddug	518	38	regions	region	NNS
cord-306904-8iteddug	518	39	of	of	IN
cord-306904-8iteddug	518	40	missing	miss	VBG
cord-306904-8iteddug	518	41	electron	electron	NN
cord-306904-8iteddug	518	42	density	density	NN
cord-306904-8iteddug	518	43	in	in	IN
cord-306904-8iteddug	518	44	the	the	DT
cord-306904-8iteddug	518	45	LGN	LGN	NNP
cord-306904-8iteddug	518	46	-	-	HYPH
cord-306904-8iteddug	518	47	TPR	TPR	NNP
cord-306904-8iteddug	518	48	/	/	SYM
cord-306904-8iteddug	518	49	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	518	50	complex	complex	NN
cord-306904-8iteddug	518	51	Figures	figure	NNS
cord-306904-8iteddug	518	52	15B	15b	CD
cord-306904-8iteddug	518	53	and	and	CC
cord-306904-8iteddug	518	54	15C	15c	JJ
cord-306904-8iteddug	518	55	shows	show	NNS
cord-306904-8iteddug	518	56	that	that	IN
cord-306904-8iteddug	518	57	fulllength	fulllength	NN
cord-306904-8iteddug	518	58	LGN	LGN	NNP
cord-306904-8iteddug	518	59	and	and	CC
cord-306904-8iteddug	518	60	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	518	61	proteins	protein	NNS
cord-306904-8iteddug	518	62	both	both	DT
cord-306904-8iteddug	518	63	belong	belong	VBP
cord-306904-8iteddug	518	64	to	to	IN
cord-306904-8iteddug	518	65	the	the	DT
cord-306904-8iteddug	518	66	category	category	NN
cord-306904-8iteddug	518	67	of	of	IN
cord-306904-8iteddug	518	68	hybrid	hybrid	JJ
cord-306904-8iteddug	518	69	proteins	protein	NNS
cord-306904-8iteddug	518	70	possessing	possess	VBG
cord-306904-8iteddug	518	71	some	some	DT
cord-306904-8iteddug	518	72	ordered	order	VBN
cord-306904-8iteddug	518	73	domains	domain	NNS
cord-306904-8iteddug	518	74	and	and	CC
cord-306904-8iteddug	518	75	significant	significant	JJ
cord-306904-8iteddug	518	76	number	number	NN
cord-306904-8iteddug	518	77	of	of	IN
cord-306904-8iteddug	518	78	intrinsically	intrinsically	RB
cord-306904-8iteddug	518	79	disordered	disordered	JJ
cord-306904-8iteddug	518	80	protein	protein	NN
cord-306904-8iteddug	518	81	regions	region	NNS
cord-306904-8iteddug	518	82	(	(	-LRB-
cord-306904-8iteddug	518	83	IDPRs	IDPRs	NNP
cord-306904-8iteddug	518	84	)	)	-RRB-
cord-306904-8iteddug	518	85	.	.	.
cord-306904-8iteddug	519	1	In	in	IN
cord-306904-8iteddug	519	2	fact	fact	NN
cord-306904-8iteddug	519	3	,	,	,
cord-306904-8iteddug	519	4	the	the	DT
cord-306904-8iteddug	519	5	GoLoco	GoLoco	NNP
cord-306904-8iteddug	519	6	motif	motif	NN
cord-306904-8iteddug	519	7	containing	contain	VBG
cord-306904-8iteddug	519	8	C	c	NN
cord-306904-8iteddug	519	9	-	-	HYPH
cord-306904-8iteddug	519	10	terminal	terminal	NN
cord-306904-8iteddug	519	11	half	half	NN
cord-306904-8iteddug	519	12	of	of	IN
cord-306904-8iteddug	519	13	human	human	JJ
cord-306904-8iteddug	519	14	LGN	LGN	NNP
cord-306904-8iteddug	519	15	(	(	-LRB-
cord-306904-8iteddug	519	16	residues	residue	NNS
cord-306904-8iteddug	519	17	350	350	CD
cord-306904-8iteddug	519	18	-	-	HYPH
cord-306904-8iteddug	519	19	684	684	CD
cord-306904-8iteddug	519	20	)	)	-RRB-
cord-306904-8iteddug	519	21	and	and	CC
cord-306904-8iteddug	519	22	the	the	DT
cord-306904-8iteddug	519	23	major	major	JJ
cord-306904-8iteddug	519	24	portion	portion	NN
cord-306904-8iteddug	519	25	of	of	IN
cord-306904-8iteddug	519	26	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	519	27	(	(	-LRB-
cord-306904-8iteddug	519	28	residues	residue	NNS
cord-306904-8iteddug	519	29	511	511	CD
cord-306904-8iteddug	519	30	-	-	HYPH
cord-306904-8iteddug	519	31	1390	1390	CD
cord-306904-8iteddug	519	32	)	)	-RRB-
cord-306904-8iteddug	519	33	are	be	VBP
cord-306904-8iteddug	519	34	predicted	predict	VBN
cord-306904-8iteddug	519	35	to	to	TO
cord-306904-8iteddug	519	36	be	be	VB
cord-306904-8iteddug	519	37	mostly	mostly	RB
cord-306904-8iteddug	519	38	disordered	disorder	VBN
cord-306904-8iteddug	519	39	by	by	IN
cord-306904-8iteddug	519	40	all	all	PDT
cord-306904-8iteddug	519	41	the	the	DT
cord-306904-8iteddug	519	42	computational	computational	JJ
cord-306904-8iteddug	519	43	tools	tool	NNS
cord-306904-8iteddug	519	44	used	use	VBN
cord-306904-8iteddug	519	45	in	in	IN
cord-306904-8iteddug	519	46	this	this	DT
cord-306904-8iteddug	519	47	study	study	NN
cord-306904-8iteddug	519	48	.	.	.
cord-306904-8iteddug	520	1	Overall	overall	RB
cord-306904-8iteddug	520	2	,	,	,
cord-306904-8iteddug	520	3	more	more	JJR
cord-306904-8iteddug	520	4	than	than	IN
cord-306904-8iteddug	520	5	40	40	CD
cord-306904-8iteddug	520	6	%	%	NN
cord-306904-8iteddug	520	7	of	of	IN
cord-306904-8iteddug	520	8	the	the	DT
cord-306904-8iteddug	520	9	LGN	LGN	NNP
cord-306904-8iteddug	520	10	residues	residue	NNS
cord-306904-8iteddug	520	11	and	and	CC
cord-306904-8iteddug	520	12	more	more	JJR
cord-306904-8iteddug	520	13	than	than	IN
cord-306904-8iteddug	520	14	50	50	CD
cord-306904-8iteddug	520	15	%	%	NN
cord-306904-8iteddug	520	16	of	of	IN
cord-306904-8iteddug	520	17	the	the	DT
cord-306904-8iteddug	520	18	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	520	19	residues	residue	NNS
cord-306904-8iteddug	520	20	are	be	VBP
cord-306904-8iteddug	520	21	predicted	predict	VBN
cord-306904-8iteddug	520	22	Figure	Figure	NNP
cord-306904-8iteddug	520	23	16	16	CD
cord-306904-8iteddug	520	24	.	.	.
cord-306904-8iteddug	521	1	(	(	-LRB-
cord-306904-8iteddug	521	2	A	a	NN
cord-306904-8iteddug	521	3	)	)	-RRB-
cord-306904-8iteddug	521	4	Evaluation	evaluation	NN
cord-306904-8iteddug	521	5	of	of	IN
cord-306904-8iteddug	521	6	the	the	DT
cord-306904-8iteddug	521	7	interactivity	interactivity	NN
cord-306904-8iteddug	521	8	of	of	IN
cord-306904-8iteddug	521	9	the	the	DT
cord-306904-8iteddug	521	10	human	human	JJ
cord-306904-8iteddug	521	11	LGN	LGN	NNP
cord-306904-8iteddug	521	12	by	by	IN
cord-306904-8iteddug	521	13	STRING	string	NN
cord-306904-8iteddug	521	14	,	,	,
cord-306904-8iteddug	521	15	which	which	WDT
cord-306904-8iteddug	521	16	is	be	VBZ
cord-306904-8iteddug	521	17	the	the	DT
cord-306904-8iteddug	521	18	online	online	JJ
cord-306904-8iteddug	521	19	database	database	NN
cord-306904-8iteddug	521	20	resource	resource	NN
cord-306904-8iteddug	521	21	Search	Search	NNP
cord-306904-8iteddug	521	22	Tool	Tool	NNP
cord-306904-8iteddug	521	23	for	for	IN
cord-306904-8iteddug	521	24	the	the	DT
cord-306904-8iteddug	521	25	Retrieval	Retrieval	NNP
cord-306904-8iteddug	521	26	of	of	IN
cord-306904-8iteddug	521	27	Interacting	interact	VBG
cord-306904-8iteddug	521	28	Genes	Genes	NNPS
cord-306904-8iteddug	521	29	that	that	WDT
cord-306904-8iteddug	521	30	provides	provide	VBZ
cord-306904-8iteddug	521	31	both	both	CC
cord-306904-8iteddug	521	32	experimental	experimental	JJ
cord-306904-8iteddug	521	33	and	and	CC
cord-306904-8iteddug	521	34	predicted	predict	VBD
cord-306904-8iteddug	521	35	interaction	interaction	NN
cord-306904-8iteddug	521	36	information	information	NN
cord-306904-8iteddug	521	37	.	.	.
cord-306904-8iteddug	522	1	59	59	CD
cord-306904-8iteddug	522	2	STRING	string	NN
cord-306904-8iteddug	522	3	produces	produce	VBZ
cord-306904-8iteddug	522	4	the	the	DT
cord-306904-8iteddug	522	5	network	network	NN
cord-306904-8iteddug	522	6	of	of	IN
cord-306904-8iteddug	522	7	predicted	predict	VBN
cord-306904-8iteddug	522	8	associations	association	NNS
cord-306904-8iteddug	522	9	for	for	IN
cord-306904-8iteddug	522	10	a	a	DT
cord-306904-8iteddug	522	11	particular	particular	JJ
cord-306904-8iteddug	522	12	group	group	NN
cord-306904-8iteddug	522	13	of	of	IN
cord-306904-8iteddug	522	14	proteins	protein	NNS
cord-306904-8iteddug	522	15	.	.	.
cord-306904-8iteddug	523	1	The	the	DT
cord-306904-8iteddug	523	2	network	network	NN
cord-306904-8iteddug	523	3	nodes	node	NNS
cord-306904-8iteddug	523	4	are	be	VBP
cord-306904-8iteddug	523	5	proteins	protein	NNS
cord-306904-8iteddug	523	6	.	.	.
cord-306904-8iteddug	524	1	The	the	DT
cord-306904-8iteddug	524	2	edges	edge	NNS
cord-306904-8iteddug	524	3	represent	represent	VBP
cord-306904-8iteddug	524	4	the	the	DT
cord-306904-8iteddug	524	5	predicted	predict	VBN
cord-306904-8iteddug	524	6	functional	functional	JJ
cord-306904-8iteddug	524	7	associations	association	NNS
cord-306904-8iteddug	524	8	.	.	.
cord-306904-8iteddug	525	1	An	an	DT
cord-306904-8iteddug	525	2	edge	edge	NN
cord-306904-8iteddug	525	3	may	may	MD
cord-306904-8iteddug	525	4	be	be	VB
cord-306904-8iteddug	525	5	drawn	draw	VBN
cord-306904-8iteddug	525	6	with	with	IN
cord-306904-8iteddug	525	7	up	up	IN
cord-306904-8iteddug	525	8	to	to	TO
cord-306904-8iteddug	525	9	7	7	CD
cord-306904-8iteddug	525	10	differently	differently	RB
cord-306904-8iteddug	525	11	colored	color	VBN
cord-306904-8iteddug	525	12	lines	line	NNS
cord-306904-8iteddug	526	1	-these	-these	JJ
cord-306904-8iteddug	526	2	lines	line	NNS
cord-306904-8iteddug	526	3	represent	represent	VBP
cord-306904-8iteddug	526	4	the	the	DT
cord-306904-8iteddug	526	5	existence	existence	NN
cord-306904-8iteddug	526	6	of	of	IN
cord-306904-8iteddug	526	7	the	the	DT
cord-306904-8iteddug	526	8	7	7	CD
cord-306904-8iteddug	526	9	types	type	NNS
cord-306904-8iteddug	526	10	of	of	IN
cord-306904-8iteddug	526	11	evidence	evidence	NN
cord-306904-8iteddug	526	12	used	use	VBN
cord-306904-8iteddug	526	13	in	in	IN
cord-306904-8iteddug	526	14	predicting	predict	VBG
cord-306904-8iteddug	526	15	the	the	DT
cord-306904-8iteddug	526	16	associations	association	NNS
cord-306904-8iteddug	526	17	.	.	.
cord-306904-8iteddug	527	1	A	a	DT
cord-306904-8iteddug	527	2	red	red	JJ
cord-306904-8iteddug	527	3	line	line	NN
cord-306904-8iteddug	527	4	indicates	indicate	VBZ
cord-306904-8iteddug	527	5	the	the	DT
cord-306904-8iteddug	527	6	presence	presence	NN
cord-306904-8iteddug	527	7	of	of	IN
cord-306904-8iteddug	527	8	fusion	fusion	NN
cord-306904-8iteddug	527	9	evidence	evidence	NN
cord-306904-8iteddug	527	10	;	;	:
cord-306904-8iteddug	527	11	a	a	DT
cord-306904-8iteddug	527	12	green	green	JJ
cord-306904-8iteddug	527	13	line	line	NN
cord-306904-8iteddug	527	14	-neighborhood	-neighborhood	HYPH
cord-306904-8iteddug	527	15	evidence	evidence	NN
cord-306904-8iteddug	527	16	;	;	:
cord-306904-8iteddug	527	17	a	a	DT
cord-306904-8iteddug	527	18	blue	blue	JJ
cord-306904-8iteddug	527	19	lineco	lineco	NN
cord-306904-8iteddug	527	20	-	-	HYPH
cord-306904-8iteddug	527	21	occurrence	occurrence	NN
cord-306904-8iteddug	527	22	evidence	evidence	NN
cord-306904-8iteddug	527	23	;	;	:
cord-306904-8iteddug	527	24	a	a	DT
cord-306904-8iteddug	527	25	purple	purple	JJ
cord-306904-8iteddug	527	26	line	line	NN
cord-306904-8iteddug	527	27	-experimental	-experimental	JJ
cord-306904-8iteddug	527	28	evidence	evidence	NN
cord-306904-8iteddug	527	29	;	;	:
cord-306904-8iteddug	527	30	a	a	DT
cord-306904-8iteddug	527	31	yellow	yellow	JJ
cord-306904-8iteddug	527	32	linetext	linetext	JJ
cord-306904-8iteddug	527	33	mining	mining	NN
cord-306904-8iteddug	527	34	evidence	evidence	NN
cord-306904-8iteddug	527	35	;	;	:
cord-306904-8iteddug	527	36	a	a	DT
cord-306904-8iteddug	527	37	light	light	JJ
cord-306904-8iteddug	527	38	blue	blue	JJ
cord-306904-8iteddug	527	39	line	line	NN
cord-306904-8iteddug	527	40	-database	-database	HYPH
cord-306904-8iteddug	527	41	evidence	evidence	NN
cord-306904-8iteddug	527	42	;	;	:
cord-306904-8iteddug	527	43	a	a	DT
cord-306904-8iteddug	527	44	black	black	JJ
cord-306904-8iteddug	527	45	lineco	lineco	NN
cord-306904-8iteddug	527	46	-	-	HYPH
cord-306904-8iteddug	527	47	expression	expression	NN
cord-306904-8iteddug	527	48	evidence	evidence	NN
cord-306904-8iteddug	527	49	.	.	.
cord-306904-8iteddug	528	1	59	59	CD
cord-306904-8iteddug	528	2	to	to	TO
cord-306904-8iteddug	528	3	be	be	VB
cord-306904-8iteddug	528	4	disordered	disordered	JJ
cord-306904-8iteddug	528	5	,	,	,
cord-306904-8iteddug	528	6	which	which	WDT
cord-306904-8iteddug	528	7	clearly	clearly	RB
cord-306904-8iteddug	528	8	places	place	VBZ
cord-306904-8iteddug	528	9	these	these	DT
cord-306904-8iteddug	528	10	proteins	protein	NNS
cord-306904-8iteddug	528	11	to	to	IN
cord-306904-8iteddug	528	12	the	the	DT
cord-306904-8iteddug	528	13	category	category	NN
cord-306904-8iteddug	528	14	of	of	IN
cord-306904-8iteddug	528	15	highly	highly	RB
cord-306904-8iteddug	528	16	disordered	disordered	JJ
cord-306904-8iteddug	528	17	proteins	protein	NNS
cord-306904-8iteddug	528	18	.	.	.
cord-306904-8iteddug	529	1	Furthermore	furthermore	RB
cord-306904-8iteddug	529	2	,	,	,
cord-306904-8iteddug	529	3	both	both	DT
cord-306904-8iteddug	529	4	proteins	protein	NNS
cord-306904-8iteddug	529	5	are	be	VBP
cord-306904-8iteddug	529	6	expected	expect	VBN
cord-306904-8iteddug	529	7	to	to	TO
cord-306904-8iteddug	529	8	have	have	VB
cord-306904-8iteddug	529	9	numerous	numerous	JJ
cord-306904-8iteddug	529	10	disorder	disorder	NN
cord-306904-8iteddug	529	11	-	-	HYPH
cord-306904-8iteddug	529	12	based	base	VBN
cord-306904-8iteddug	529	13	interaction	interaction	NN
cord-306904-8iteddug	529	14	sites	site	NNS
cord-306904-8iteddug	529	15	.	.	.
cord-306904-8iteddug	530	1	These	these	DT
cord-306904-8iteddug	530	2	can	can	MD
cord-306904-8iteddug	530	3	be	be	VB
cord-306904-8iteddug	530	4	identified	identify	VBN
cord-306904-8iteddug	530	5	by	by	IN
cord-306904-8iteddug	530	6	ANCHOR	ANCHOR	NNP
cord-306904-8iteddug	530	7	,	,	,
cord-306904-8iteddug	530	8	15,16	15,16	CD
cord-306904-8iteddug	530	9	a	a	DT
cord-306904-8iteddug	530	10	computational	computational	JJ
cord-306904-8iteddug	530	11	tool	tool	NN
cord-306904-8iteddug	530	12	that	that	WDT
cord-306904-8iteddug	530	13	relies	rely	VBZ
cord-306904-8iteddug	530	14	on	on	IN
cord-306904-8iteddug	530	15	the	the	DT
cord-306904-8iteddug	530	16	pair	pair	NN
cord-306904-8iteddug	530	17	-	-	HYPH
cord-306904-8iteddug	530	18	wise	wise	JJ
cord-306904-8iteddug	530	19	energy	energy	NN
cord-306904-8iteddug	530	20	estimation	estimation	NN
cord-306904-8iteddug	530	21	approach	approach	NN
cord-306904-8iteddug	530	22	developed	develop	VBN
cord-306904-8iteddug	530	23	for	for	IN
cord-306904-8iteddug	530	24	the	the	DT
cord-306904-8iteddug	530	25	general	general	JJ
cord-306904-8iteddug	530	26	disorder	disorder	NN
cord-306904-8iteddug	530	27	prediction	prediction	NN
cord-306904-8iteddug	530	28	method	method	NN
cord-306904-8iteddug	530	29	IUPred	IUPred	NNP
cord-306904-8iteddug	530	30	,	,	,
cord-306904-8iteddug	530	31	201	201	CD
cord-306904-8iteddug	530	32	,	,	,
cord-306904-8iteddug	530	33	202	202	CD
cord-306904-8iteddug	530	34	and	and	CC
cord-306904-8iteddug	530	35	is	be	VBZ
cord-306904-8iteddug	530	36	based	base	VBN
cord-306904-8iteddug	530	37	on	on	IN
cord-306904-8iteddug	530	38	the	the	DT
cord-306904-8iteddug	530	39	hypothesis	hypothesis	NN
cord-306904-8iteddug	530	40	that	that	IN
cord-306904-8iteddug	530	41	long	long	JJ
cord-306904-8iteddug	530	42	regions	region	NNS
cord-306904-8iteddug	530	43	of	of	IN
cord-306904-8iteddug	530	44	disorder	disorder	NN
cord-306904-8iteddug	530	45	contain	contain	VBP
cord-306904-8iteddug	530	46	localized	localize	VBN
cord-306904-8iteddug	530	47	potential	potential	JJ
cord-306904-8iteddug	530	48	binding	bind	VBG
cord-306904-8iteddug	530	49	sites	site	NNS
cord-306904-8iteddug	530	50	that	that	WDT
cord-306904-8iteddug	530	51	can	can	MD
cord-306904-8iteddug	530	52	not	not	RB
cord-306904-8iteddug	530	53	form	form	VB
cord-306904-8iteddug	530	54	enough	enough	JJ
cord-306904-8iteddug	530	55	favorable	favorable	JJ
cord-306904-8iteddug	530	56	intra	intra	JJ
cord-306904-8iteddug	530	57	-	-	JJ
cord-306904-8iteddug	530	58	chain	chain	JJ
cord-306904-8iteddug	530	59	interactions	interaction	NNS
cord-306904-8iteddug	530	60	to	to	TO
cord-306904-8iteddug	530	61	fold	fold	VB
cord-306904-8iteddug	530	62	on	on	RP
cord-306904-8iteddug	530	63	their	-PRON-	PRP$
cord-306904-8iteddug	530	64	own	own	JJ
cord-306904-8iteddug	530	65	,	,	,
cord-306904-8iteddug	530	66	but	but	CC
cord-306904-8iteddug	530	67	are	be	VBP
cord-306904-8iteddug	530	68	likely	likely	JJ
cord-306904-8iteddug	530	69	to	to	TO
cord-306904-8iteddug	530	70	gain	gain	VB
cord-306904-8iteddug	530	71	stabilizing	stabilize	VBG
cord-306904-8iteddug	530	72	energy	energy	NN
cord-306904-8iteddug	530	73	by	by	IN
cord-306904-8iteddug	530	74	interacting	interact	VBG
cord-306904-8iteddug	530	75	with	with	IN
cord-306904-8iteddug	530	76	a	a	DT
cord-306904-8iteddug	530	77	globular	globular	JJ
cord-306904-8iteddug	530	78	protein	protein	NN
cord-306904-8iteddug	530	79	partner	partner	NN
cord-306904-8iteddug	530	80	.	.	.
cord-306904-8iteddug	531	1	15	15	CD
cord-306904-8iteddug	531	2	,	,	,
cord-306904-8iteddug	531	3	16	16	CD
cord-306904-8iteddug	532	1	Here	here	RB
cord-306904-8iteddug	532	2	the	the	DT
cord-306904-8iteddug	532	3	term	term	NN
cord-306904-8iteddug	532	4	ANCHOR	anchor	NN
cord-306904-8iteddug	532	5	-	-	HYPH
cord-306904-8iteddug	532	6	indicated	indicate	VBN
cord-306904-8iteddug	532	7	binding	bind	VBG
cord-306904-8iteddug	532	8	site	site	NN
cord-306904-8iteddug	532	9	(	(	-LRB-
cord-306904-8iteddug	532	10	AiBS	AiBS	NNP
cord-306904-8iteddug	532	11	)	)	-RRB-
cord-306904-8iteddug	532	12	is	be	VBZ
cord-306904-8iteddug	532	13	used	use	VBN
cord-306904-8iteddug	532	14	to	to	TO
cord-306904-8iteddug	532	15	identify	identify	VB
cord-306904-8iteddug	532	16	a	a	DT
cord-306904-8iteddug	532	17	region	region	NN
cord-306904-8iteddug	532	18	of	of	IN
cord-306904-8iteddug	532	19	a	a	DT
cord-306904-8iteddug	532	20	protein	protein	NN
cord-306904-8iteddug	532	21	suggested	suggest	VBN
cord-306904-8iteddug	532	22	by	by	IN
cord-306904-8iteddug	532	23	the	the	DT
cord-306904-8iteddug	532	24	ANCHOR	anchor	NN
cord-306904-8iteddug	532	25	algorithm	algorithm	NN
cord-306904-8iteddug	532	26	to	to	TO
cord-306904-8iteddug	532	27	have	have	VB
cord-306904-8iteddug	532	28	significant	significant	JJ
cord-306904-8iteddug	532	29	potential	potential	NN
cord-306904-8iteddug	532	30	to	to	TO
cord-306904-8iteddug	532	31	be	be	VB
cord-306904-8iteddug	532	32	a	a	DT
cord-306904-8iteddug	532	33	binding	binding	JJ
cord-306904-8iteddug	532	34	site	site	NN
cord-306904-8iteddug	532	35	for	for	IN
cord-306904-8iteddug	532	36	an	an	DT
cord-306904-8iteddug	532	37	appropriate	appropriate	JJ
cord-306904-8iteddug	532	38	but	but	CC
cord-306904-8iteddug	532	39	typically	typically	RB
cord-306904-8iteddug	532	40	unidentified	unidentified	JJ
cord-306904-8iteddug	532	41	partner	partner	NN
cord-306904-8iteddug	532	42	protein	protein	NN
cord-306904-8iteddug	532	43	.	.	.
cord-306904-8iteddug	533	1	This	this	DT
cord-306904-8iteddug	533	2	analysis	analysis	NN
cord-306904-8iteddug	533	3	revealed	reveal	VBD
cord-306904-8iteddug	533	4	that	that	IN
cord-306904-8iteddug	533	5	there	there	EX
cord-306904-8iteddug	533	6	are	be	VBP
cord-306904-8iteddug	533	7	10	10	CD
cord-306904-8iteddug	533	8	AiBSs	aibs	NNS
cord-306904-8iteddug	533	9	in	in	IN
cord-306904-8iteddug	533	10	LGN	LGN	NNP
cord-306904-8iteddug	533	11	(	(	-LRB-
cord-306904-8iteddug	533	12	residues	residue	NNS
cord-306904-8iteddug	533	13	370	370	CD
cord-306904-8iteddug	533	14	-	-	SYM
cord-306904-8iteddug	533	15	379	379	CD
cord-306904-8iteddug	533	16	,	,	,
cord-306904-8iteddug	533	17	436	436	CD
cord-306904-8iteddug	533	18	-	-	SYM
cord-306904-8iteddug	533	19	452	452	CD
cord-306904-8iteddug	533	20	,	,	,
cord-306904-8iteddug	533	21	491	491	CD
cord-306904-8iteddug	533	22	-	-	SYM
cord-306904-8iteddug	533	23	499	499	CD
cord-306904-8iteddug	533	24	,	,	,
cord-306904-8iteddug	533	25	508	508	CD
cord-306904-8iteddug	533	26	-	-	SYM
cord-306904-8iteddug	533	27	513	513	CD
cord-306904-8iteddug	533	28	,	,	,
cord-306904-8iteddug	533	29	531	531	CD
cord-306904-8iteddug	533	30	-	-	SYM
cord-306904-8iteddug	533	31	537	537	CD
cord-306904-8iteddug	533	32	,	,	,
cord-306904-8iteddug	533	33	545	545	CD
cord-306904-8iteddug	533	34	-	-	SYM
cord-306904-8iteddug	533	35	553	553	CD
cord-306904-8iteddug	533	36	,	,	,
cord-306904-8iteddug	533	37	566	566	CD
cord-306904-8iteddug	533	38	-	-	SYM
cord-306904-8iteddug	533	39	573	573	CD
cord-306904-8iteddug	533	40	,	,	,
cord-306904-8iteddug	533	41	596	596	CD
cord-306904-8iteddug	533	42	-	-	SYM
cord-306904-8iteddug	533	43	607	607	CD
cord-306904-8iteddug	533	44	,	,	,
cord-306904-8iteddug	533	45	629	629	CD
cord-306904-8iteddug	533	46	-	-	SYM
cord-306904-8iteddug	533	47	638	638	CD
cord-306904-8iteddug	533	48	and	and	CC
cord-306904-8iteddug	533	49	661	661	CD
cord-306904-8iteddug	533	50	-	-	SYM
cord-306904-8iteddug	533	51	671	671	CD
cord-306904-8iteddug	533	52	)	)	-RRB-
cord-306904-8iteddug	533	53	,	,	,
cord-306904-8iteddug	533	54	whereas	whereas	IN
cord-306904-8iteddug	533	55	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	533	56	contains	contain	VBZ
cord-306904-8iteddug	533	57	23	23	CD
cord-306904-8iteddug	533	58	AiBSs	AiBSs	NNPS
cord-306904-8iteddug	533	59	(	(	-LRB-
cord-306904-8iteddug	533	60	residues	residue	NNS
cord-306904-8iteddug	533	61	534	534	CD
cord-306904-8iteddug	533	62	-	-	HYPH
cord-306904-8iteddug	533	63	554	554	CD
cord-306904-8iteddug	533	64	,	,	,
cord-306904-8iteddug	533	65	609	609	CD
cord-306904-8iteddug	533	66	-	-	SYM
cord-306904-8iteddug	533	67	617	617	CD
cord-306904-8iteddug	533	68	,	,	,
cord-306904-8iteddug	533	69	622	622	CD
cord-306904-8iteddug	533	70	-	-	SYM
cord-306904-8iteddug	533	71	636	636	CD
cord-306904-8iteddug	533	72	,	,	,
cord-306904-8iteddug	533	73	652	652	CD
cord-306904-8iteddug	533	74	-	-	SYM
cord-306904-8iteddug	533	75	662	662	CD
cord-306904-8iteddug	533	76	,	,	,
cord-306904-8iteddug	533	77	704	704	CD
cord-306904-8iteddug	533	78	-	-	HYPH
cord-306904-8iteddug	533	79	715	715	CD
cord-306904-8iteddug	533	80	,	,	,
cord-306904-8iteddug	533	81	747	747	CD
cord-306904-8iteddug	533	82	-	-	HYPH
cord-306904-8iteddug	533	83	779	779	CD
cord-306904-8iteddug	533	84	,	,	,
cord-306904-8iteddug	533	85	792	792	CD
cord-306904-8iteddug	533	86	-	-	SYM
cord-306904-8iteddug	533	87	804	804	CD
cord-306904-8iteddug	533	88	,	,	,
cord-306904-8iteddug	533	89	828	828	CD
cord-306904-8iteddug	533	90	-	-	SYM
cord-306904-8iteddug	533	91	878	878	CD
cord-306904-8iteddug	533	92	,	,	,
cord-306904-8iteddug	533	93	896	896	CD
cord-306904-8iteddug	533	94	-	-	SYM
cord-306904-8iteddug	533	95	909	909	CD
cord-306904-8iteddug	533	96	,	,	,
cord-306904-8iteddug	533	97	932	932	CD
cord-306904-8iteddug	533	98	-	-	SYM
cord-306904-8iteddug	533	99	949	949	CD
cord-306904-8iteddug	533	100	,	,	,
cord-306904-8iteddug	533	101	958	958	CD
cord-306904-8iteddug	533	102	-	-	SYM
cord-306904-8iteddug	533	103	967	967	CD
cord-306904-8iteddug	533	104	,	,	,
cord-306904-8iteddug	533	105	983	983	CD
cord-306904-8iteddug	533	106	-	-	SYM
cord-306904-8iteddug	533	107	1019	1019	CD
cord-306904-8iteddug	533	108	,	,	,
cord-306904-8iteddug	533	109	1023	1023	CD
cord-306904-8iteddug	533	110	-	-	SYM
cord-306904-8iteddug	533	111	1077	1077	CD
cord-306904-8iteddug	533	112	,	,	,
cord-306904-8iteddug	533	113	 	 	_SP
cord-306904-8iteddug	533	114	1087	1087	CD
cord-306904-8iteddug	533	115	-	-	SYM
cord-306904-8iteddug	533	116	1100	1100	CD
cord-306904-8iteddug	533	117	,	,	,
cord-306904-8iteddug	533	118	1106	1106	CD
cord-306904-8iteddug	533	119	-	-	SYM
cord-306904-8iteddug	533	120	1114	1114	CD
cord-306904-8iteddug	533	121	,	,	,
cord-306904-8iteddug	533	122	1119	1119	CD
cord-306904-8iteddug	533	123	-	-	SYM
cord-306904-8iteddug	533	124	1129	1129	CD
cord-306904-8iteddug	533	125	,	,	,
cord-306904-8iteddug	533	126	 	 	_SP
cord-306904-8iteddug	533	127	1138	1138	CD
cord-306904-8iteddug	533	128	-	-	HYPH
cord-306904-8iteddug	533	129	1171	1171	CD
cord-306904-8iteddug	533	130	,	,	,
cord-306904-8iteddug	533	131	1192	1192	CD
cord-306904-8iteddug	533	132	-	-	SYM
cord-306904-8iteddug	533	133	1220	1220	CD
cord-306904-8iteddug	533	134	,	,	,
cord-306904-8iteddug	533	135	1245	1245	CD
cord-306904-8iteddug	533	136	-	-	SYM
cord-306904-8iteddug	533	137	1250	1250	CD
cord-306904-8iteddug	533	138	,	,	,
cord-306904-8iteddug	533	139	 	 	_SP
cord-306904-8iteddug	533	140	1290	1290	CD
cord-306904-8iteddug	533	141	-	-	HYPH
cord-306904-8iteddug	533	142	1297	1297	CD
cord-306904-8iteddug	533	143	,	,	,
cord-306904-8iteddug	533	144	1312	1312	CD
cord-306904-8iteddug	533	145	-	-	SYM
cord-306904-8iteddug	533	146	1319	1319	CD
cord-306904-8iteddug	533	147	,	,	,
cord-306904-8iteddug	533	148	1336	1336	CD
cord-306904-8iteddug	533	149	-	-	SYM
cord-306904-8iteddug	533	150	1342	1342	CD
cord-306904-8iteddug	533	151	,	,	,
cord-306904-8iteddug	533	152	and	and	CC
cord-306904-8iteddug	533	153	 	 	_SP
cord-306904-8iteddug	533	154	1424	1424	CD
cord-306904-8iteddug	533	155	-	-	SYM
cord-306904-8iteddug	533	156	1431	1431	CD
cord-306904-8iteddug	533	157	)	)	-RRB-
cord-306904-8iteddug	533	158	.	.	.
cord-306904-8iteddug	534	1	Of	of	IN
cord-306904-8iteddug	534	2	special	special	JJ
cord-306904-8iteddug	534	3	interest	interest	NN
cord-306904-8iteddug	534	4	is	be	VBZ
cord-306904-8iteddug	534	5	the	the	DT
cord-306904-8iteddug	534	6	fact	fact	NN
cord-306904-8iteddug	534	7	that	that	IN
cord-306904-8iteddug	534	8	the	the	DT
cord-306904-8iteddug	534	9	901	901	CD
cord-306904-8iteddug	534	10	-	-	SYM
cord-306904-8iteddug	534	11	951	951	CD
cord-306904-8iteddug	534	12	fragment	fragment	NN
cord-306904-8iteddug	534	13	of	of	IN
cord-306904-8iteddug	534	14	human	human	JJ
cord-306904-8iteddug	534	15	Frmdp1	Frmdp1	NNP
cord-306904-8iteddug	534	16	used	use	VBN
cord-306904-8iteddug	534	17	in	in	IN
cord-306904-8iteddug	534	18	the	the	DT
cord-306904-8iteddug	534	19	mentioned	mention	VBN
cord-306904-8iteddug	534	20	structural	structural	JJ
cord-306904-8iteddug	534	21	analysis	analysis	NN
cord-306904-8iteddug	534	22	188	188	CD
cord-306904-8iteddug	534	23	is	be	VBZ
cord-306904-8iteddug	534	24	predicted	predict	VBN
cord-306904-8iteddug	534	25	to	to	TO
cord-306904-8iteddug	534	26	overlap	overlap	VB
cord-306904-8iteddug	534	27	with	with	IN
cord-306904-8iteddug	534	28	2	2	CD
cord-306904-8iteddug	534	29	AiBSs	AiBSs	NNP
cord-306904-8iteddug	534	30	(	(	-LRB-
cord-306904-8iteddug	534	31	residues	residue	NNS
cord-306904-8iteddug	534	32	896	896	CD
cord-306904-8iteddug	534	33	-	-	HYPH
cord-306904-8iteddug	534	34	909	909	CD
cord-306904-8iteddug	534	35	and	and	CC
cord-306904-8iteddug	534	36	932	932	CD
cord-306904-8iteddug	534	37	-	-	SYM
cord-306904-8iteddug	534	38	949	949	CD
cord-306904-8iteddug	534	39	)	)	-RRB-
cord-306904-8iteddug	534	40	.	.	.
cord-306904-8iteddug	535	1	This	this	DT
cord-306904-8iteddug	535	2	is	be	VBZ
cord-306904-8iteddug	535	3	a	a	DT
cord-306904-8iteddug	535	4	clear	clear	JJ
cord-306904-8iteddug	535	5	indication	indication	NN
cord-306904-8iteddug	535	6	that	that	IN
cord-306904-8iteddug	535	7	intrinsic	intrinsic	JJ
cord-306904-8iteddug	535	8	disorder	disorder	NN
cord-306904-8iteddug	535	9	plays	play	VBZ
cord-306904-8iteddug	535	10	a	a	DT
cord-306904-8iteddug	535	11	role	role	NN
cord-306904-8iteddug	535	12	in	in	IN
cord-306904-8iteddug	535	13	the	the	DT
cord-306904-8iteddug	535	14	formation	formation	NN
cord-306904-8iteddug	535	15	of	of	IN
cord-306904-8iteddug	535	16	the	the	DT
cord-306904-8iteddug	535	17	LGN	LGN	NNP
cord-306904-8iteddug	535	18	-	-	HYPH
cord-306904-8iteddug	535	19	TPR	TPR	NNP
cord-306904-8iteddug	535	20	/	/	SYM
cord-306904-8iteddug	535	21	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	535	22	complex	complex	NN
cord-306904-8iteddug	535	23	.	.	.
cord-306904-8iteddug	536	1	Davenport	Davenport	NNP
cord-306904-8iteddug	536	2	et	et	NNP
cord-306904-8iteddug	536	3	al	al	NNP
cord-306904-8iteddug	536	4	.	.	NNP
cord-306904-8iteddug	536	5	reported	report	VBD
cord-306904-8iteddug	536	6	a	a	DT
cord-306904-8iteddug	536	7	crystal	crystal	NN
cord-306904-8iteddug	536	8	structure	structure	NN
cord-306904-8iteddug	536	9	of	of	IN
cord-306904-8iteddug	536	10	human	human	JJ
cord-306904-8iteddug	536	11	sirtuin-1catalytic	sirtuin-1catalytic	JJ
cord-306904-8iteddug	536	12	domain	domain	NN
cord-306904-8iteddug	536	13	(	(	-LRB-
cord-306904-8iteddug	536	14	residues	residue	NNS
cord-306904-8iteddug	536	15	234	234	CD
cord-306904-8iteddug	536	16	-	-	HYPH
cord-306904-8iteddug	536	17	510	510	CD
cord-306904-8iteddug	536	18	)	)	-RRB-
cord-306904-8iteddug	536	19	in	in	IN
cord-306904-8iteddug	536	20	complex	complex	NN
cord-306904-8iteddug	536	21	with	with	IN
cord-306904-8iteddug	536	22	its	-PRON-	PRP$
cord-306904-8iteddug	536	23	C	c	NN
cord-306904-8iteddug	536	24	-	-	HYPH
cord-306904-8iteddug	536	25	terminal	terminal	NN
cord-306904-8iteddug	536	26	regulatory	regulatory	JJ
cord-306904-8iteddug	536	27	segment	segment	NN
cord-306904-8iteddug	536	28	(	(	-LRB-
cord-306904-8iteddug	536	29	CTR	CTR	NNP
cord-306904-8iteddug	536	30	,	,	,
cord-306904-8iteddug	536	31	residues	residue	VBZ
cord-306904-8iteddug	536	32	641	641	CD
cord-306904-8iteddug	536	33	-	-	SYM
cord-306904-8iteddug	536	34	665	665	CD
cord-306904-8iteddug	536	35	)	)	-RRB-
cord-306904-8iteddug	536	36	.	.	.
cord-306904-8iteddug	537	1	203	203	CD
cord-306904-8iteddug	538	1	In	in	IN
cord-306904-8iteddug	538	2	this	this	DT
cord-306904-8iteddug	538	3	structure	structure	NN
cord-306904-8iteddug	538	4	(	(	-LRB-
cord-306904-8iteddug	538	5	see	see	VB
cord-306904-8iteddug	538	6	Fig	Fig	NNP
cord-306904-8iteddug	538	7	.	.	.
cord-306904-8iteddug	539	1	17A	17A	NNS
cord-306904-8iteddug	539	2	,	,	,
cord-306904-8iteddug	539	3	PDB	PDB	NNP
cord-306904-8iteddug	539	4	ID	ID	NNP
cord-306904-8iteddug	539	5	:	:	:
cord-306904-8iteddug	539	6	4IG9	4ig9	CD
cord-306904-8iteddug	539	7	)	)	-RRB-
cord-306904-8iteddug	539	8	,	,	,
cord-306904-8iteddug	539	9	the	the	DT
cord-306904-8iteddug	539	10	catalytic	catalytic	JJ
cord-306904-8iteddug	539	11	NAD	NAD	NNP
cord-306904-8iteddug	539	12	C	C	NNP
cord-306904-8iteddug	539	13	-binding	-binding	NN
cord-306904-8iteddug	539	14	domain	domain	NN
cord-306904-8iteddug	539	15	adopts	adopt	VBZ
cord-306904-8iteddug	539	16	the	the	DT
cord-306904-8iteddug	539	17	canonical	canonical	JJ
cord-306904-8iteddug	539	18	sirtuin	sirtuin	NN
cord-306904-8iteddug	539	19	fold	fold	NN
cord-306904-8iteddug	539	20	,	,	,
cord-306904-8iteddug	539	21	whereas	whereas	IN
cord-306904-8iteddug	539	22	CTR	CTR	NNP
cord-306904-8iteddug	539	23	forms	form	VBZ
cord-306904-8iteddug	539	24	a	a	DT
cord-306904-8iteddug	539	25	b	b	NN
cord-306904-8iteddug	539	26	-	-	HYPH
cord-306904-8iteddug	539	27	hairpin	hairpin	NN
cord-306904-8iteddug	539	28	structure	structure	NN
cord-306904-8iteddug	539	29	complementing	complement	VBG
cord-306904-8iteddug	539	30	the	the	DT
cord-306904-8iteddug	539	31	b	b	NN
cord-306904-8iteddug	539	32	-	-	HYPH
cord-306904-8iteddug	539	33	sheet	sheet	NN
cord-306904-8iteddug	539	34	of	of	IN
cord-306904-8iteddug	539	35	the	the	DT
cord-306904-8iteddug	539	36	catalytic	catalytic	JJ
cord-306904-8iteddug	539	37	domain	domain	NN
cord-306904-8iteddug	539	38	and	and	CC
cord-306904-8iteddug	539	39	covering	cover	VBG
cord-306904-8iteddug	539	40	an	an	DT
cord-306904-8iteddug	539	41	essentially	essentially	RB
cord-306904-8iteddug	539	42	invariant	invariant	JJ
cord-306904-8iteddug	539	43	hydrophobic	hydrophobic	JJ
cord-306904-8iteddug	539	44	surface	surface	NN
cord-306904-8iteddug	539	45	.	.	.
cord-306904-8iteddug	540	1	203	203	CD
cord-306904-8iteddug	540	2	Biological	biological	JJ
cord-306904-8iteddug	540	3	significance	significance	NN
cord-306904-8iteddug	540	4	of	of	IN
cord-306904-8iteddug	540	5	the	the	DT
cord-306904-8iteddug	540	6	sirtuin	sirtuin	NNP
cord-306904-8iteddug	540	7	family	family	NN
cord-306904-8iteddug	540	8	was	be	VBD
cord-306904-8iteddug	540	9	outlined	outline	VBN
cord-306904-8iteddug	540	10	in	in	IN
cord-306904-8iteddug	540	11	the	the	DT
cord-306904-8iteddug	540	12	previous	previous	JJ
cord-306904-8iteddug	540	13	section	section	NN
cord-306904-8iteddug	540	14	.	.	.
cord-306904-8iteddug	541	1	Human	Human	NNP
cord-306904-8iteddug	541	2	sirtuin-1	sirtuin-1	NNP
cord-306904-8iteddug	541	3	(	(	-LRB-
cord-306904-8iteddug	541	4	Sirt1	Sirt1	NNP
cord-306904-8iteddug	541	5	)	)	-RRB-
cord-306904-8iteddug	541	6	is	be	VBZ
cord-306904-8iteddug	541	7	implicated	implicate	VBN
cord-306904-8iteddug	541	8	in	in	IN
cord-306904-8iteddug	541	9	a	a	DT
cord-306904-8iteddug	541	10	wide	wide	JJ
cord-306904-8iteddug	541	11	range	range	NN
cord-306904-8iteddug	541	12	of	of	IN
cord-306904-8iteddug	541	13	human	human	JJ
cord-306904-8iteddug	541	14	diseases	disease	NNS
cord-306904-8iteddug	541	15	due	due	JJ
cord-306904-8iteddug	541	16	to	to	IN
cord-306904-8iteddug	541	17	the	the	DT
cord-306904-8iteddug	541	18	fact	fact	NN
cord-306904-8iteddug	541	19	that	that	IN
cord-306904-8iteddug	541	20	this	this	DT
cord-306904-8iteddug	541	21	enzyme	enzyme	NN
cord-306904-8iteddug	541	22	plays	play	VBZ
cord-306904-8iteddug	541	23	multiple	multiple	JJ
cord-306904-8iteddug	541	24	roles	role	NNS
cord-306904-8iteddug	541	25	in	in	IN
cord-306904-8iteddug	541	26	cellular	cellular	JJ
cord-306904-8iteddug	541	27	processes	process	NNS
cord-306904-8iteddug	541	28	ranging	range	VBG
cord-306904-8iteddug	541	29	from	from	IN
cord-306904-8iteddug	541	30	energy	energy	NN
cord-306904-8iteddug	541	31	metabolism	metabolism	NN
cord-306904-8iteddug	541	32	to	to	IN
cord-306904-8iteddug	541	33	cell	cell	NN
cord-306904-8iteddug	541	34	survival	survival	NN
cord-306904-8iteddug	541	35	via	via	IN
cord-306904-8iteddug	541	36	it	-PRON-	PRP
cord-306904-8iteddug	541	37	ability	ability	NN
cord-306904-8iteddug	541	38	to	to	TO
cord-306904-8iteddug	541	39	deacetylate	deacetylate	VB
cord-306904-8iteddug	541	40	a	a	DT
cord-306904-8iteddug	541	41	wide	wide	JJ
cord-306904-8iteddug	541	42	range	range	NN
cord-306904-8iteddug	541	43	of	of	IN
cord-306904-8iteddug	541	44	substrates	substrate	NNS
cord-306904-8iteddug	541	45	,	,	,
cord-306904-8iteddug	541	46	such	such	JJ
cord-306904-8iteddug	541	47	as	as	IN
cord-306904-8iteddug	541	48	p53	p53	NN
cord-306904-8iteddug	541	49	,	,	,
cord-306904-8iteddug	541	50	NF	NF	NNP
cord-306904-8iteddug	541	51	-	-	HYPH
cord-306904-8iteddug	541	52	kB	kB	NNP
cord-306904-8iteddug	541	53	,	,	,
cord-306904-8iteddug	541	54	FOXO	FOXO	NNP
cord-306904-8iteddug	541	55	transcription	transcription	NN
cord-306904-8iteddug	541	56	factors	factor	NNS
cord-306904-8iteddug	541	57	,	,	,
cord-306904-8iteddug	541	58	and	and	CC
cord-306904-8iteddug	542	1	PGC-1a	PGC-1a	NNP
cord-306904-8iteddug	542	2	.	.	.
cord-306904-8iteddug	543	1	[	[	-LRB-
cord-306904-8iteddug	543	2	204	204	CD
cord-306904-8iteddug	543	3	]	]	-RRB-
cord-306904-8iteddug	543	4	[	[	-LRB-
cord-306904-8iteddug	543	5	205	205	CD
cord-306904-8iteddug	543	6	]	]	-RRB-
cord-306904-8iteddug	544	1	[	[	-LRB-
cord-306904-8iteddug	544	2	206	206	CD
cord-306904-8iteddug	544	3	]	]	-RRB-
cord-306904-8iteddug	544	4	Deacetylation	deacetylation	NN
cord-306904-8iteddug	544	5	activity	activity	NN
cord-306904-8iteddug	544	6	of	of	IN
cord-306904-8iteddug	544	7	Sirt1	Sirt1	NNS
cord-306904-8iteddug	544	8	was	be	VBD
cord-306904-8iteddug	544	9	shown	show	VBN
cord-306904-8iteddug	544	10	to	to	TO
cord-306904-8iteddug	544	11	be	be	VB
cord-306904-8iteddug	544	12	affected	affect	VBN
cord-306904-8iteddug	544	13	by	by	IN
cord-306904-8iteddug	544	14	various	various	JJ
cord-306904-8iteddug	544	15	regions	region	NNS
cord-306904-8iteddug	544	16	located	locate	VBN
cord-306904-8iteddug	544	17	within	within	IN
cord-306904-8iteddug	544	18	the	the	DT
cord-306904-8iteddug	544	19	long	long	JJ
cord-306904-8iteddug	544	20	N	n	CD
cord-306904-8iteddug	544	21	-	-	:
cord-306904-8iteddug	544	22	and	and	CC
cord-306904-8iteddug	544	23	C	C	NNP
cord-306904-8iteddug	544	24	-	-	HYPH
cord-306904-8iteddug	544	25	termini	termini	NNP
cord-306904-8iteddug	544	26	that	that	WDT
cord-306904-8iteddug	544	27	flank	flank	VBP
cord-306904-8iteddug	544	28	the	the	DT
cord-306904-8iteddug	544	29	Sirt1	Sirt1	NNP
cord-306904-8iteddug	544	30	catalytic	catalytic	JJ
cord-306904-8iteddug	544	31	domain	domain	NN
cord-306904-8iteddug	544	32	.	.	.
cord-306904-8iteddug	545	1	207	207	CD
cord-306904-8iteddug	545	2	,	,	,
cord-306904-8iteddug	545	3	208	208	CD
cord-306904-8iteddug	545	4	Figure	figure	NN
cord-306904-8iteddug	545	5	17B	17b	CD
cord-306904-8iteddug	545	6	illustrates	illustrate	VBZ
cord-306904-8iteddug	545	7	that	that	IN
cord-306904-8iteddug	545	8	in	in	IN
cord-306904-8iteddug	545	9	agreement	agreement	NN
cord-306904-8iteddug	545	10	with	with	IN
cord-306904-8iteddug	545	11	a	a	DT
cord-306904-8iteddug	545	12	recent	recent	JJ
cord-306904-8iteddug	545	13	bioinformatics	bioinformatics	NN
cord-306904-8iteddug	545	14	study	study	NN
cord-306904-8iteddug	545	15	revealing	reveal	VBG
cord-306904-8iteddug	545	16	that	that	IN
cord-306904-8iteddug	545	17	N	N	NNP
cord-306904-8iteddug	545	18	-	-	:
cord-306904-8iteddug	545	19	and	and	CC
cord-306904-8iteddug	545	20	C	c	NN
cord-306904-8iteddug	545	21	-	-	HYPH
cord-306904-8iteddug	545	22	terminal	terminal	NN
cord-306904-8iteddug	545	23	segments	segment	NNS
cord-306904-8iteddug	545	24	of	of	IN
cord-306904-8iteddug	545	25	sirtuins	sirtuin	NNS
cord-306904-8iteddug	545	26	in	in	IN
cord-306904-8iteddug	545	27	all	all	DT
cord-306904-8iteddug	545	28	known	know	VBN
cord-306904-8iteddug	545	29	organisms	organism	NNS
cord-306904-8iteddug	545	30	are	be	VBP
cord-306904-8iteddug	545	31	expected	expect	VBN
cord-306904-8iteddug	545	32	to	to	TO
cord-306904-8iteddug	545	33	be	be	VB
cord-306904-8iteddug	545	34	intrinsically	intrinsically	RB
cord-306904-8iteddug	545	35	disordered	disordered	JJ
cord-306904-8iteddug	545	36	,	,	,
cord-306904-8iteddug	546	1	209	209	CD
cord-306904-8iteddug	546	2	both	both	DT
cord-306904-8iteddug	546	3	termini	terminus	NNS
cord-306904-8iteddug	546	4	of	of	IN
cord-306904-8iteddug	546	5	human	human	JJ
cord-306904-8iteddug	546	6	Sirt1	Sirt1	NNS
cord-306904-8iteddug	546	7	(	(	-LRB-
cord-306904-8iteddug	546	8	UniProt	UniProt	NNP
cord-306904-8iteddug	546	9	ID	ID	NNP
cord-306904-8iteddug	546	10	:	:	:
cord-306904-8iteddug	546	11	Q96EB6	q96eb6	XX
cord-306904-8iteddug	546	12	,	,	,
cord-306904-8iteddug	546	13	residues	residue	NNS
cord-306904-8iteddug	546	14	1	1	CD
cord-306904-8iteddug	546	15	-	-	HYPH
cord-306904-8iteddug	546	16	250	250	CD
cord-306904-8iteddug	546	17	and	and	CC
cord-306904-8iteddug	546	18	500	500	CD
cord-306904-8iteddug	546	19	-	-	HYPH
cord-306904-8iteddug	546	20	747	747	CD
cord-306904-8iteddug	546	21	)	)	-RRB-
cord-306904-8iteddug	546	22	are	be	VBP
cord-306904-8iteddug	546	23	predicted	predict	VBN
cord-306904-8iteddug	546	24	to	to	TO
cord-306904-8iteddug	546	25	be	be	VB
cord-306904-8iteddug	546	26	mostly	mostly	RB
cord-306904-8iteddug	546	27	disordered	disordered	JJ
cord-306904-8iteddug	546	28	,	,	,
cord-306904-8iteddug	546	29	whereas	whereas	IN
cord-306904-8iteddug	546	30	the	the	DT
cord-306904-8iteddug	546	31	central	central	JJ
cord-306904-8iteddug	546	32	catalytic	catalytic	JJ
cord-306904-8iteddug	546	33	domain	domain	NN
cord-306904-8iteddug	546	34	is	be	VBZ
cord-306904-8iteddug	546	35	mostly	mostly	RB
cord-306904-8iteddug	546	36	ordered	order	VBN
cord-306904-8iteddug	546	37	.	.	.
cord-306904-8iteddug	547	1	The	the	DT
cord-306904-8iteddug	547	2	ANCHOR	anchor	NN
cord-306904-8iteddug	547	3	analysis	analysis	NN
cord-306904-8iteddug	547	4	15	15	CD
cord-306904-8iteddug	547	5	,	,	,
cord-306904-8iteddug	547	6	16	16	CD
cord-306904-8iteddug	547	7	revealed	reveal	VBD
cord-306904-8iteddug	547	8	that	that	IN
cord-306904-8iteddug	547	9	human	human	JJ
cord-306904-8iteddug	547	10	Sirt1	Sirt1	NNP
cord-306904-8iteddug	547	11	contains	contain	VBZ
cord-306904-8iteddug	547	12	14	14	CD
cord-306904-8iteddug	547	13	AiBSs	AiBSs	NNP
cord-306904-8iteddug	547	14	located	locate	VBN
cord-306904-8iteddug	547	15	at	at	IN
cord-306904-8iteddug	547	16	the	the	DT
cord-306904-8iteddug	547	17	residues	residue	NNS
cord-306904-8iteddug	547	18	1	1	CD
cord-306904-8iteddug	547	19	-	-	SYM
cord-306904-8iteddug	547	20	33	33	CD
cord-306904-8iteddug	547	21	,	,	,
cord-306904-8iteddug	547	22	43	43	CD
cord-306904-8iteddug	547	23	-	-	SYM
cord-306904-8iteddug	547	24	49	49	CD
cord-306904-8iteddug	547	25	,	,	,
cord-306904-8iteddug	547	26	53	53	CD
cord-306904-8iteddug	547	27	-	-	SYM
cord-306904-8iteddug	547	28	125	125	CD
cord-306904-8iteddug	547	29	,	,	,
cord-306904-8iteddug	547	30	133	133	CD
cord-306904-8iteddug	547	31	-	-	SYM
cord-306904-8iteddug	547	32	169	169	CD
cord-306904-8iteddug	547	33	,	,	,
cord-306904-8iteddug	547	34	184	184	CD
cord-306904-8iteddug	547	35	-	-	SYM
cord-306904-8iteddug	547	36	193	193	CD
cord-306904-8iteddug	547	37	,	,	,
cord-306904-8iteddug	547	38	220	220	CD
cord-306904-8iteddug	547	39	-	-	SYM
cord-306904-8iteddug	547	40	225	225	CD
cord-306904-8iteddug	547	41	,	,	,
cord-306904-8iteddug	547	42	498	498	CD
cord-306904-8iteddug	547	43	-503	-503	NN
cord-306904-8iteddug	547	44	,	,	,
cord-306904-8iteddug	547	45	521	521	CD
cord-306904-8iteddug	547	46	-	-	SYM
cord-306904-8iteddug	547	47	528	528	CD
cord-306904-8iteddug	547	48	,	,	,
cord-306904-8iteddug	547	49	549	549	CD
cord-306904-8iteddug	547	50	-	-	SYM
cord-306904-8iteddug	547	51	574	574	CD
cord-306904-8iteddug	547	52	,	,	,
cord-306904-8iteddug	547	53	588	588	CD
cord-306904-8iteddug	547	54	-	-	SYM
cord-306904-8iteddug	547	55	593	593	CD
cord-306904-8iteddug	547	56	,	,	,
cord-306904-8iteddug	547	57	618	618	CD
cord-306904-8iteddug	547	58	-	-	SYM
cord-306904-8iteddug	547	59	624	624	CD
cord-306904-8iteddug	547	60	,	,	,
cord-306904-8iteddug	547	61	637	637	CD
cord-306904-8iteddug	547	62	-	-	SYM
cord-306904-8iteddug	547	63	672	672	CD
cord-306904-8iteddug	547	64	,	,	,
cord-306904-8iteddug	547	65	691	691	CD
cord-306904-8iteddug	547	66	-	-	SYM
cord-306904-8iteddug	547	67	706	706	CD
cord-306904-8iteddug	547	68	,	,	,
cord-306904-8iteddug	547	69	and	and	CC
cord-306904-8iteddug	547	70	710	710	CD
cord-306904-8iteddug	547	71	-	-	HYPH
cord-306904-8iteddug	547	72	744	744	CD
cord-306904-8iteddug	547	73	.	.	.
cord-306904-8iteddug	548	1	It	-PRON-	PRP
cord-306904-8iteddug	548	2	is	be	VBZ
cord-306904-8iteddug	548	3	important	important	JJ
cord-306904-8iteddug	548	4	to	to	TO
cord-306904-8iteddug	548	5	emphasize	emphasize	VB
cord-306904-8iteddug	548	6	here	here	RB
cord-306904-8iteddug	548	7	that	that	IN
cord-306904-8iteddug	548	8	the	the	DT
cord-306904-8iteddug	548	9	CTR	CTR	NNP
cord-306904-8iteddug	548	10	(	(	-LRB-
cord-306904-8iteddug	548	11	residues	residue	NNS
cord-306904-8iteddug	548	12	641	641	CD
cord-306904-8iteddug	548	13	-	-	HYPH
cord-306904-8iteddug	548	14	665	665	CD
cord-306904-8iteddug	548	15	)	)	-RRB-
cord-306904-8iteddug	548	16	used	use	VBN
cord-306904-8iteddug	548	17	in	in	IN
cord-306904-8iteddug	548	18	the	the	DT
cord-306904-8iteddug	548	19	mentioned	mention	VBN
cord-306904-8iteddug	548	20	above	above	IN
cord-306904-8iteddug	548	21	structural	structural	JJ
cord-306904-8iteddug	548	22	analysis	analysis	NN
cord-306904-8iteddug	548	23	of	of	IN
cord-306904-8iteddug	548	24	human	human	JJ
cord-306904-8iteddug	548	25	Sirt1	Sirt1	NNP
cord-306904-8iteddug	548	26	203	203	CD
cord-306904-8iteddug	548	27	is	be	VBZ
cord-306904-8iteddug	548	28	completely	completely	RB
cord-306904-8iteddug	548	29	embedded	embed	VBN
cord-306904-8iteddug	548	30	within	within	IN
cord-306904-8iteddug	548	31	one	one	CD
cord-306904-8iteddug	548	32	of	of	IN
cord-306904-8iteddug	548	33	the	the	DT
cord-306904-8iteddug	548	34	AiBSs	AiBSs	NNP
cord-306904-8iteddug	548	35	(	(	-LRB-
cord-306904-8iteddug	548	36	residues	residue	NNS
cord-306904-8iteddug	548	37	637	637	CD
cord-306904-8iteddug	548	38	-	-	HYPH
cord-306904-8iteddug	548	39	672	672	CD
cord-306904-8iteddug	548	40	)	)	-RRB-
cord-306904-8iteddug	548	41	.	.	.
cord-306904-8iteddug	549	1	The	the	DT
cord-306904-8iteddug	549	2	endosome	endosome	NN
cord-306904-8iteddug	549	3	-	-	HYPH
cord-306904-8iteddug	549	4	associated	associate	VBN
cord-306904-8iteddug	549	5	deubiquitinase	deubiquitinase	NN
cord-306904-8iteddug	549	6	AMSH	AMSH	NNP
cord-306904-8iteddug	549	7	Davies	Davies	NNP
cord-306904-8iteddug	549	8	et	et	NNP
cord-306904-8iteddug	549	9	al	al	NNP
cord-306904-8iteddug	549	10	.	.	NNP
cord-306904-8iteddug	549	11	performed	perform	VBD
cord-306904-8iteddug	549	12	a	a	DT
cord-306904-8iteddug	549	13	systematic	systematic	JJ
cord-306904-8iteddug	549	14	mutational	mutational	JJ
cord-306904-8iteddug	549	15	analysis	analysis	NN
cord-306904-8iteddug	549	16	to	to	TO
cord-306904-8iteddug	549	17	elucidate	elucidate	VB
cord-306904-8iteddug	549	18	the	the	DT
cord-306904-8iteddug	549	19	molecular	molecular	JJ
cord-306904-8iteddug	549	20	mechanisms	mechanism	NNS
cord-306904-8iteddug	549	21	of	of	IN
cord-306904-8iteddug	549	22	activation	activation	NN
cord-306904-8iteddug	549	23	of	of	IN
cord-306904-8iteddug	549	24	AMSH	AMSH	NNP
cord-306904-8iteddug	549	25	[	[	-LRB-
cord-306904-8iteddug	549	26	associated	associate	VBN
cord-306904-8iteddug	549	27	molecule	molecule	NN
cord-306904-8iteddug	549	28	with	with	IN
cord-306904-8iteddug	549	29	a	a	DT
cord-306904-8iteddug	549	30	Src	Src	NNP
cord-306904-8iteddug	549	31	homology	homology	NN
cord-306904-8iteddug	549	32	3	3	CD
cord-306904-8iteddug	549	33	domain	domain	NN
cord-306904-8iteddug	549	34	of	of	IN
cord-306904-8iteddug	549	35	signal	signal	NN
cord-306904-8iteddug	549	36	transducing	transducing	NN
cord-306904-8iteddug	549	37	adaptor	adaptor	NN
cord-306904-8iteddug	549	38	molecule	molecule	NN
cord-306904-8iteddug	549	39	(	(	-LRB-
cord-306904-8iteddug	549	40	STAM	STAM	NNP
cord-306904-8iteddug	549	41	)	)	-RRB-
cord-306904-8iteddug	549	42	]	]	-RRB-
cord-306904-8iteddug	549	43	,	,	,
cord-306904-8iteddug	549	44	a	a	DT
cord-306904-8iteddug	549	45	deubiquitinating	deubiquitinating	NN
cord-306904-8iteddug	549	46	enzyme	enzyme	NN
cord-306904-8iteddug	549	47	(	(	-LRB-
cord-306904-8iteddug	549	48	DUB	DUB	NNP
cord-306904-8iteddug	549	49	)	)	-RRB-
cord-306904-8iteddug	549	50	with	with	IN
cord-306904-8iteddug	549	51	exquisite	exquisite	JJ
cord-306904-8iteddug	549	52	specificity	specificity	NN
cord-306904-8iteddug	549	53	for	for	IN
cord-306904-8iteddug	549	54	Lys63-linked	Lys63-linked	NNP
cord-306904-8iteddug	549	55	polyubiquitin	polyubiquitin	NNP
cord-306904-8iteddug	549	56	chains	chain	NNS
cord-306904-8iteddug	549	57	and	and	CC
cord-306904-8iteddug	549	58	recruitment	recruitment	NN
cord-306904-8iteddug	549	59	of	of	IN
cord-306904-8iteddug	549	60	this	this	DT
cord-306904-8iteddug	549	61	protein	protein	NN
cord-306904-8iteddug	549	62	to	to	IN
cord-306904-8iteddug	549	63	the	the	DT
cord-306904-8iteddug	549	64	endosomal	endosomal	NNP
cord-306904-8iteddug	549	65	sorting	sorting	NN
cord-306904-8iteddug	549	66	complexes	complex	NNS
cord-306904-8iteddug	549	67	required	require	VBN
cord-306904-8iteddug	549	68	for	for	IN
cord-306904-8iteddug	549	69	transport	transport	NN
cord-306904-8iteddug	549	70	(	(	-LRB-
cord-306904-8iteddug	549	71	ESCRT	ESCRT	NNP
cord-306904-8iteddug	549	72	)	)	-RRB-
cord-306904-8iteddug	549	73	machinery	machinery	NN
cord-306904-8iteddug	549	74	.	.	.
cord-306904-8iteddug	550	1	210	210	CD
cord-306904-8iteddug	551	1	The	the	DT
cord-306904-8iteddug	551	2	fact	fact	NN
cord-306904-8iteddug	551	3	that	that	IN
cord-306904-8iteddug	551	4	the	the	DT
cord-306904-8iteddug	551	5	mutations	mutation	NNS
cord-306904-8iteddug	551	6	AMSH	AMSH	NNP
cord-306904-8iteddug	551	7	were	be	VBD
cord-306904-8iteddug	551	8	implemented	implement	VBN
cord-306904-8iteddug	551	9	in	in	IN
cord-306904-8iteddug	551	10	microcephaly	microcephaly	NN
cord-306904-8iteddug	551	11	capillary	capillary	JJ
cord-306904-8iteddug	551	12	malformation	malformation	NN
cord-306904-8iteddug	552	1	(	(	-LRB-
cord-306904-8iteddug	552	2	MIC	MIC	NNP
cord-306904-8iteddug	552	3	-	-	HYPH
cord-306904-8iteddug	552	4	CAP	CAP	NNP
cord-306904-8iteddug	552	5	)	)	-RRB-
cord-306904-8iteddug	552	6	syndrome	syndrome	NN
cord-306904-8iteddug	552	7	in	in	IN
cord-306904-8iteddug	552	8	children	child	NNS
cord-306904-8iteddug	552	9	211	211	CD
cord-306904-8iteddug	552	10	further	further	RB
cord-306904-8iteddug	552	11	reiterates	reiterate	VBZ
cord-306904-8iteddug	552	12	the	the	DT
cord-306904-8iteddug	552	13	importance	importance	NN
cord-306904-8iteddug	552	14	of	of	IN
cord-306904-8iteddug	552	15	this	this	DT
cord-306904-8iteddug	552	16	study	study	NN
cord-306904-8iteddug	552	17	.	.	.
cord-306904-8iteddug	553	1	AMSH	AMSH	NNP
cord-306904-8iteddug	553	2	is	be	VBZ
cord-306904-8iteddug	553	3	a	a	DT
cord-306904-8iteddug	553	4	member	member	NN
cord-306904-8iteddug	553	5	of	of	IN
cord-306904-8iteddug	553	6	the	the	DT
cord-306904-8iteddug	553	7	JAMM	JAMM	NNP
cord-306904-8iteddug	553	8	(	(	-LRB-
cord-306904-8iteddug	553	9	JAB1	JAB1	NNP
cord-306904-8iteddug	553	10	/	/	SYM
cord-306904-8iteddug	553	11	MPN	MPN	NNP
cord-306904-8iteddug	553	12	/	/	SYM
cord-306904-8iteddug	553	13	MOV34	MOV34	NNP
cord-306904-8iteddug	553	14	)	)	-RRB-
cord-306904-8iteddug	553	15	family	family	NN
cord-306904-8iteddug	553	16	of	of	IN
cord-306904-8iteddug	553	17	DUBs	dub	NNS
cord-306904-8iteddug	553	18	involved	involve	VBN
cord-306904-8iteddug	553	19	in	in	IN
cord-306904-8iteddug	553	20	the	the	DT
cord-306904-8iteddug	553	21	regulation	regulation	NN
cord-306904-8iteddug	553	22	of	of	IN
cord-306904-8iteddug	553	23	ubiquitin	ubiquitin	NN
cord-306904-8iteddug	553	24	signaling	signaling	NN
cord-306904-8iteddug	553	25	by	by	IN
cord-306904-8iteddug	553	26	catalyzing	catalyze	VBG
cord-306904-8iteddug	553	27	the	the	DT
cord-306904-8iteddug	553	28	hydrolysis	hydrolysis	NN
cord-306904-8iteddug	553	29	of	of	IN
cord-306904-8iteddug	553	30	isopeptide	isopeptide	NN
cord-306904-8iteddug	553	31	(	(	-LRB-
cord-306904-8iteddug	553	32	or	or	CC
cord-306904-8iteddug	553	33	peptide	peptide	JJ
cord-306904-8iteddug	553	34	)	)	-RRB-
cord-306904-8iteddug	553	35	bonds	bond	NNS
cord-306904-8iteddug	553	36	between	between	IN
cord-306904-8iteddug	553	37	ubiquitin	ubiquitin	NN
cord-306904-8iteddug	553	38	and	and	CC
cord-306904-8iteddug	553	39	target	target	NN
cord-306904-8iteddug	553	40	proteins	protein	NNS
cord-306904-8iteddug	553	41	or	or	CC
cord-306904-8iteddug	553	42	within	within	IN
cord-306904-8iteddug	553	43	polymeric	polymeric	JJ
cord-306904-8iteddug	553	44	chains	chain	NNS
cord-306904-8iteddug	553	45	of	of	IN
cord-306904-8iteddug	553	46	ubiquitin	ubiquitin	NN
cord-306904-8iteddug	553	47	.	.	.
cord-306904-8iteddug	554	1	212	212	CD
cord-306904-8iteddug	555	1	The	the	DT
cord-306904-8iteddug	555	2	catalytic	catalytic	JJ
cord-306904-8iteddug	555	3	activity	activity	NN
cord-306904-8iteddug	555	4	of	of	IN
cord-306904-8iteddug	555	5	AMSH	AMSH	NNP
cord-306904-8iteddug	555	6	is	be	VBZ
cord-306904-8iteddug	555	7	stimulated	stimulate	VBN
cord-306904-8iteddug	555	8	upon	upon	IN
cord-306904-8iteddug	555	9	binding	bind	VBG
cord-306904-8iteddug	555	10	to	to	IN
cord-306904-8iteddug	555	11	STAM	STAM	NNP
cord-306904-8iteddug	555	12	,	,	,
cord-306904-8iteddug	555	13	which	which	WDT
cord-306904-8iteddug	555	14	is	be	VBZ
cord-306904-8iteddug	555	15	a	a	DT
cord-306904-8iteddug	555	16	member	member	NN
cord-306904-8iteddug	555	17	of	of	IN
cord-306904-8iteddug	555	18	the	the	DT
cord-306904-8iteddug	555	19	ESCRT-0	ESCRT-0	NNP
cord-306904-8iteddug	555	20	complex	complex	NN
cord-306904-8iteddug	555	21	.	.	.
cord-306904-8iteddug	556	1	Here	here	RB
cord-306904-8iteddug	556	2	,	,	,
cord-306904-8iteddug	556	3	the	the	DT
cord-306904-8iteddug	556	4	AMSH	AMSH	NNP
cord-306904-8iteddug	556	5	-	-	HYPH
cord-306904-8iteddug	556	6	STAM	stam	NN
cord-306904-8iteddug	556	7	interaction	interaction	NN
cord-306904-8iteddug	556	8	is	be	VBZ
cord-306904-8iteddug	556	9	conducted	conduct	VBN
cord-306904-8iteddug	556	10	through	through	IN
cord-306904-8iteddug	556	11	the	the	DT
cord-306904-8iteddug	556	12	binding	binding	NN
cord-306904-8iteddug	556	13	of	of	IN
cord-306904-8iteddug	556	14	the	the	DT
cord-306904-8iteddug	556	15	SH3	SH3	NNP
cord-306904-8iteddug	556	16	binding	bind	VBG
cord-306904-8iteddug	556	17	motif	motif	NN
cord-306904-8iteddug	556	18	of	of	IN
cord-306904-8iteddug	556	19	AMSH	AMSH	NNP
cord-306904-8iteddug	556	20	to	to	IN
cord-306904-8iteddug	556	21	the	the	DT
cord-306904-8iteddug	556	22	SH3	SH3	NNP
cord-306904-8iteddug	556	23	domain	domain	NN
cord-306904-8iteddug	556	24	of	of	IN
cord-306904-8iteddug	556	25	the	the	DT
cord-306904-8iteddug	556	26	STAM	stam	NN
cord-306904-8iteddug	556	27	.	.	.
cord-306904-8iteddug	557	1	213	213	CD
cord-306904-8iteddug	557	2	Davies	Davies	NNP
cord-306904-8iteddug	557	3	et	et	NNP
cord-306904-8iteddug	557	4	al	al	NNP
cord-306904-8iteddug	557	5	.	.	.
cord-306904-8iteddug	558	1	used	use	VBN
cord-306904-8iteddug	558	2	in	in	IN
cord-306904-8iteddug	558	3	their	-PRON-	PRP$
cord-306904-8iteddug	558	4	analysis	analysis	NN
cord-306904-8iteddug	558	5	the	the	DT
cord-306904-8iteddug	558	6	catalytic	catalytic	JJ
cord-306904-8iteddug	558	7	domain	domain	NN
cord-306904-8iteddug	558	8	of	of	IN
cord-306904-8iteddug	558	9	AMSH	AMSH	NNP
cord-306904-8iteddug	558	10	(	(	-LRB-
cord-306904-8iteddug	558	11	residues	residue	NNS
cord-306904-8iteddug	558	12	219	219	CD
cord-306904-8iteddug	558	13	-	-	SYM
cord-306904-8iteddug	558	14	424	424	CD
cord-306904-8iteddug	558	15	)	)	-RRB-
cord-306904-8iteddug	558	16	.	.	.
cord-306904-8iteddug	559	1	210	210	CD
cord-306904-8iteddug	559	2	Figure	figure	NN
cord-306904-8iteddug	559	3	14C	14c	NN
cord-306904-8iteddug	559	4	represents	represent	VBZ
cord-306904-8iteddug	559	5	the	the	DT
cord-306904-8iteddug	559	6	results	result	NNS
cord-306904-8iteddug	559	7	of	of	IN
cord-306904-8iteddug	559	8	the	the	DT
cord-306904-8iteddug	559	9	disorder	disorder	NN
cord-306904-8iteddug	559	10	analysis	analysis	NN
cord-306904-8iteddug	559	11	of	of	IN
cord-306904-8iteddug	559	12	human	human	JJ
cord-306904-8iteddug	559	13	AMSH	AMSH	NNP
cord-306904-8iteddug	559	14	(	(	-LRB-
cord-306904-8iteddug	559	15	UniProt	UniProt	NNP
cord-306904-8iteddug	559	16	ID	ID	NNP
cord-306904-8iteddug	559	17	:	:	:
cord-306904-8iteddug	560	1	O95630	O95630	NNP
cord-306904-8iteddug	560	2	)	)	-RRB-
cord-306904-8iteddug	560	3	and	and	CC
cord-306904-8iteddug	560	4	shows	show	VBZ
cord-306904-8iteddug	560	5	that	that	IN
cord-306904-8iteddug	560	6	this	this	DT
cord-306904-8iteddug	560	7	protein	protein	NN
cord-306904-8iteddug	560	8	contains	contain	VBZ
cord-306904-8iteddug	560	9	a	a	DT
cord-306904-8iteddug	560	10	long	long	JJ
cord-306904-8iteddug	560	11	IDPR	IDPR	NNP
cord-306904-8iteddug	560	12	(	(	-LRB-
cord-306904-8iteddug	560	13	residues	residue	NNS
cord-306904-8iteddug	560	14	90	90	CD
cord-306904-8iteddug	560	15	-	-	SYM
cord-306904-8iteddug	560	16	250	250	CD
cord-306904-8iteddug	560	17	)	)	-RRB-
cord-306904-8iteddug	560	18	thereby	thereby	RB
cord-306904-8iteddug	560	19	illustrating	illustrate	VBG
cord-306904-8iteddug	560	20	that	that	IN
cord-306904-8iteddug	560	21	the	the	DT
cord-306904-8iteddug	560	22	N	n	CD
cord-306904-8iteddug	560	23	-	-	HYPH
cord-306904-8iteddug	560	24	terminal	terminal	JJ
cord-306904-8iteddug	560	25	part	part	NN
cord-306904-8iteddug	560	26	of	of	IN
cord-306904-8iteddug	560	27	the	the	DT
cord-306904-8iteddug	560	28	analyzed	analyze	VBN
cord-306904-8iteddug	560	29	catalytic	catalytic	JJ
cord-306904-8iteddug	560	30	domain	domain	NN
cord-306904-8iteddug	560	31	is	be	VBZ
cord-306904-8iteddug	560	32	predicted	predict	VBN
cord-306904-8iteddug	560	33	to	to	TO
cord-306904-8iteddug	560	34	be	be	VB
cord-306904-8iteddug	560	35	disordered	disordered	JJ
cord-306904-8iteddug	560	36	.	.	.
cord-306904-8iteddug	561	1	TonB	TonB	NNP
cord-306904-8iteddug	561	2	is	be	VBZ
cord-306904-8iteddug	561	3	the	the	DT
cord-306904-8iteddug	561	4	E.coli	e.coli	NN
cord-306904-8iteddug	561	5	inner	inner	JJ
cord-306904-8iteddug	561	6	membrane	membrane	NN
cord-306904-8iteddug	561	7	protein	protein	NN
cord-306904-8iteddug	561	8	,	,	,
cord-306904-8iteddug	561	9	which	which	WDT
cord-306904-8iteddug	561	10	possesses	possess	VBZ
cord-306904-8iteddug	561	11	a	a	DT
cord-306904-8iteddug	561	12	polyproline	polyproline	NN
cord-306904-8iteddug	561	13	motif	motif	NN
cord-306904-8iteddug	561	14	(	(	-LRB-
cord-306904-8iteddug	561	15	residues	residue	NNS
cord-306904-8iteddug	561	16	70	70	CD
cord-306904-8iteddug	561	17	-	-	SYM
cord-306904-8iteddug	561	18	81	81	CD
cord-306904-8iteddug	561	19	)	)	-RRB-
cord-306904-8iteddug	561	20	that	that	WDT
cord-306904-8iteddug	561	21	may	may	MD
cord-306904-8iteddug	561	22	span	span	VB
cord-306904-8iteddug	561	23	the	the	DT
cord-306904-8iteddug	561	24	length	length	NN
cord-306904-8iteddug	561	25	of	of	IN
cord-306904-8iteddug	561	26	the	the	DT
cord-306904-8iteddug	561	27	periplasmic	periplasmic	JJ
cord-306904-8iteddug	561	28	space	space	NN
cord-306904-8iteddug	561	29	216	216	CD
cord-306904-8iteddug	561	30	and	and	CC
cord-306904-8iteddug	561	31	a	a	DT
cord-306904-8iteddug	561	32	globular	globular	JJ
cord-306904-8iteddug	561	33	C	c	NN
cord-306904-8iteddug	561	34	-	-	HYPH
cord-306904-8iteddug	561	35	terminal	terminal	NN
cord-306904-8iteddug	561	36	domain	domain	NN
cord-306904-8iteddug	561	37	(	(	-LRB-
cord-306904-8iteddug	561	38	residues	residue	NNS
cord-306904-8iteddug	561	39	that	that	WDT
cord-306904-8iteddug	561	40	interacts	interact	VBZ
cord-306904-8iteddug	561	41	with	with	IN
cord-306904-8iteddug	561	42	the	the	DT
cord-306904-8iteddug	561	43	transporters	transporter	NNS
cord-306904-8iteddug	561	44	.	.	.
cord-306904-8iteddug	562	1	217	217	CD
cord-306904-8iteddug	562	2	,	,	,
cord-306904-8iteddug	562	3	218	218	CD
cord-306904-8iteddug	562	4	Figure	figure	NN
cord-306904-8iteddug	562	5	18A	18a	NN
cord-306904-8iteddug	562	6	shows	show	VBZ
cord-306904-8iteddug	562	7	that	that	IN
cord-306904-8iteddug	562	8	the	the	DT
cord-306904-8iteddug	562	9	N	n	CD
cord-306904-8iteddug	562	10	-	-	HYPH
cord-306904-8iteddug	562	11	terminal	terminal	JJ
cord-306904-8iteddug	562	12	half	half	NN
cord-306904-8iteddug	562	13	of	of	IN
cord-306904-8iteddug	562	14	the	the	DT
cord-306904-8iteddug	562	15	periplasmic	periplasmic	JJ
cord-306904-8iteddug	562	16	domain	domain	NN
cord-306904-8iteddug	562	17	of	of	IN
cord-306904-8iteddug	562	18	TonB	TonB	NNP
cord-306904-8iteddug	562	19	protein	protein	NN
cord-306904-8iteddug	562	20	(	(	-LRB-
cord-306904-8iteddug	562	21	UniProt	UniProt	NNP
cord-306904-8iteddug	562	22	ID	ID	NNP
cord-306904-8iteddug	562	23	:	:	:
cord-306904-8iteddug	563	1	P02929	P02929	NNP
cord-306904-8iteddug	563	2	)	)	-RRB-
cord-306904-8iteddug	563	3	is	be	VBZ
cord-306904-8iteddug	563	4	predicted	predict	VBN
cord-306904-8iteddug	563	5	to	to	TO
cord-306904-8iteddug	563	6	be	be	VB
cord-306904-8iteddug	563	7	highly	highly	RB
cord-306904-8iteddug	563	8	disordered	disordered	JJ
cord-306904-8iteddug	563	9	,	,	,
cord-306904-8iteddug	563	10	whereas	whereas	IN
cord-306904-8iteddug	563	11	its	-PRON-	PRP$
cord-306904-8iteddug	563	12	C	c	NN
cord-306904-8iteddug	563	13	-	-	HYPH
cord-306904-8iteddug	563	14	terminal	terminal	NN
cord-306904-8iteddug	563	15	domain	domain	NN
cord-306904-8iteddug	563	16	possesses	possess	VBZ
cord-306904-8iteddug	563	17	significant	significant	JJ
cord-306904-8iteddug	563	18	amount	amount	NN
cord-306904-8iteddug	563	19	of	of	IN
cord-306904-8iteddug	563	20	order	order	NN
cord-306904-8iteddug	563	21	.	.	.
cord-306904-8iteddug	564	1	Figure	figure	NN
cord-306904-8iteddug	564	2	18B	18B	NNS
cord-306904-8iteddug	564	3	illustrates	illustrate	VBZ
cord-306904-8iteddug	564	4	an	an	DT
cord-306904-8iteddug	564	5	important	important	JJ
cord-306904-8iteddug	564	6	point	point	NN
cord-306904-8iteddug	564	7	that	that	IN
cord-306904-8iteddug	564	8	the	the	DT
cord-306904-8iteddug	564	9	dimer	dimer	NN
cord-306904-8iteddug	564	10	formed	form	VBN
cord-306904-8iteddug	564	11	by	by	IN
cord-306904-8iteddug	564	12	the	the	DT
cord-306904-8iteddug	564	13	truncated	truncated	JJ
cord-306904-8iteddug	564	14	periplasmic	periplasmic	JJ
cord-306904-8iteddug	564	15	domain	domain	NN
cord-306904-8iteddug	564	16	(	(	-LRB-
cord-306904-8iteddug	564	17	residues	residue	NNS
cord-306904-8iteddug	564	18	150	150	CD
cord-306904-8iteddug	564	19	-	-	HYPH
cord-306904-8iteddug	564	20	239	239	CD
cord-306904-8iteddug	564	21	)	)	-RRB-
cord-306904-8iteddug	564	22	is	be	VBZ
cord-306904-8iteddug	564	23	a	a	DT
cord-306904-8iteddug	564	24	highly	highly	RB
cord-306904-8iteddug	564	25	intertwined	intertwine	VBN
cord-306904-8iteddug	564	26	and	and	CC
cord-306904-8iteddug	564	27	elongated	elongated	JJ
cord-306904-8iteddug	564	28	structure	structure	NN
cord-306904-8iteddug	564	29	with	with	IN
cord-306904-8iteddug	564	30	noticeable	noticeable	JJ
cord-306904-8iteddug	564	31	domain	domain	NN
cord-306904-8iteddug	564	32	swapping	swapping	NN
cord-306904-8iteddug	564	33	.	.	.
cord-306904-8iteddug	565	1	A	a	DT
cord-306904-8iteddug	565	2	crystal	crystal	JJ
cord-306904-8iteddug	565	3	structure	structure	NN
cord-306904-8iteddug	565	4	of	of	IN
cord-306904-8iteddug	565	5	the	the	DT
cord-306904-8iteddug	565	6	TonB	TonB	NNP
cord-306904-8iteddug	565	7	-	-	HYPH
cord-306904-8iteddug	565	8	FhuA	FhuA	NNP
cord-306904-8iteddug	565	9	complex	complex	NN
cord-306904-8iteddug	565	10	is	be	VBZ
cord-306904-8iteddug	565	11	shown	show	VBN
cord-306904-8iteddug	565	12	in	in	IN
cord-306904-8iteddug	565	13	Figure	Figure	NNP
cord-306904-8iteddug	565	14	18C	18C	NNP
cord-306904-8iteddug	565	15	.	.	.
cord-306904-8iteddug	566	1	Curiously	curiously	RB
cord-306904-8iteddug	566	2	,	,	,
cord-306904-8iteddug	566	3	although	although	IN
cord-306904-8iteddug	566	4	the	the	DT
cord-306904-8iteddug	566	5	entire	entire	JJ
cord-306904-8iteddug	566	6	periplasmic	periplasmic	JJ
cord-306904-8iteddug	566	7	domain	domain	NN
cord-306904-8iteddug	566	8	of	of	IN
cord-306904-8iteddug	566	9	TonB	TonB	NNP
cord-306904-8iteddug	566	10	was	be	VBD
cord-306904-8iteddug	566	11	used	use	VBN
cord-306904-8iteddug	566	12	in	in	IN
cord-306904-8iteddug	566	13	the	the	DT
cord-306904-8iteddug	566	14	crystallization	crystallization	NN
cord-306904-8iteddug	566	15	experiment	experiment	NN
cord-306904-8iteddug	566	16	,	,	,
cord-306904-8iteddug	566	17	residues	residue	VBZ
cord-306904-8iteddug	566	18	39	39	CD
cord-306904-8iteddug	566	19	-	-	SYM
cord-306904-8iteddug	566	20	157	157	CD
cord-306904-8iteddug	566	21	and	and	CC
cord-306904-8iteddug	566	22	236	236	CD
cord-306904-8iteddug	566	23	-	-	SYM
cord-306904-8iteddug	566	24	239	239	CD
cord-306904-8iteddug	566	25	are	be	VBP
cord-306904-8iteddug	566	26	not	not	RB
cord-306904-8iteddug	566	27	seen	see	VBN
cord-306904-8iteddug	566	28	in	in	IN
cord-306904-8iteddug	566	29	the	the	DT
cord-306904-8iteddug	566	30	resulting	result	VBG
cord-306904-8iteddug	566	31	structure	structure	NN
cord-306904-8iteddug	566	32	,	,	,
cord-306904-8iteddug	566	33	clearly	clearly	RB
cord-306904-8iteddug	566	34	indicating	indicate	VBG
cord-306904-8iteddug	566	35	that	that	IN
cord-306904-8iteddug	566	36	these	these	DT
cord-306904-8iteddug	566	37	regions	region	NNS
cord-306904-8iteddug	566	38	are	be	VBP
cord-306904-8iteddug	566	39	likely	likely	JJ
cord-306904-8iteddug	566	40	to	to	TO
cord-306904-8iteddug	566	41	preserve	preserve	VB
cord-306904-8iteddug	566	42	mostly	mostly	RB
cord-306904-8iteddug	566	43	disordered	disordered	JJ
cord-306904-8iteddug	566	44	structure	structure	NN
cord-306904-8iteddug	566	45	even	even	RB
cord-306904-8iteddug	566	46	in	in	IN
cord-306904-8iteddug	566	47	the	the	DT
cord-306904-8iteddug	566	48	bound	bind	VBN
cord-306904-8iteddug	566	49	form	form	NN
cord-306904-8iteddug	566	50	of	of	IN
cord-306904-8iteddug	566	51	TonB.	tonb.	NN
cord-306904-8iteddug	567	1	The	the	DT
cord-306904-8iteddug	567	2	disordered	disordered	JJ
cord-306904-8iteddug	567	3	N	n	NN
cord-306904-8iteddug	567	4	-	-	HYPH
cord-306904-8iteddug	567	5	terminal	terminal	NN
cord-306904-8iteddug	567	6	and	and	CC
cord-306904-8iteddug	567	7	C	c	NN
cord-306904-8iteddug	567	8	-	-	HYPH
cord-306904-8iteddug	567	9	terminal	terminal	NN
cord-306904-8iteddug	567	10	tails	tail	NNS
cord-306904-8iteddug	567	11	clearly	clearly	RB
cord-306904-8iteddug	567	12	have	have	VBP
cord-306904-8iteddug	567	13	functional	functional	JJ
cord-306904-8iteddug	567	14	importance	importance	NN
cord-306904-8iteddug	567	15	since	since	IN
cord-306904-8iteddug	567	16	they	-PRON-	PRP
cord-306904-8iteddug	567	17	contains	contain	VBZ
cord-306904-8iteddug	567	18	AiBSs	AiBSs	NNP
cord-306904-8iteddug	567	19	,	,	,
cord-306904-8iteddug	567	20	3	3	CD
cord-306904-8iteddug	567	21	at	at	IN
cord-306904-8iteddug	567	22	the	the	DT
cord-306904-8iteddug	567	23	N	n	CD
cord-306904-8iteddug	567	24	-	-	HYPH
cord-306904-8iteddug	567	25	terminus	terminus	NN
cord-306904-8iteddug	567	26	(	(	-LRB-
cord-306904-8iteddug	567	27	residues	residue	NNS
cord-306904-8iteddug	567	28	39	39	CD
cord-306904-8iteddug	567	29	-	-	SYM
cord-306904-8iteddug	567	30	65	65	CD
cord-306904-8iteddug	567	31	,	,	,
cord-306904-8iteddug	567	32	92	92	CD
cord-306904-8iteddug	567	33	-	-	SYM
cord-306904-8iteddug	567	34	95	95	CD
cord-306904-8iteddug	567	35	,	,	,
cord-306904-8iteddug	567	36	and	and	CC
cord-306904-8iteddug	567	37	124	124	CD
cord-306904-8iteddug	567	38	-	-	SYM
cord-306904-8iteddug	567	39	164	164	CD
cord-306904-8iteddug	567	40	)	)	-RRB-
cord-306904-8iteddug	567	41	and	and	CC
cord-306904-8iteddug	567	42	one	one	CD
cord-306904-8iteddug	567	43	at	at	IN
cord-306904-8iteddug	567	44	the	the	DT
cord-306904-8iteddug	567	45	C	C	NNP
cord-306904-8iteddug	567	46	-	-	HYPH
cord-306904-8iteddug	567	47	terminus	terminus	NN
cord-306904-8iteddug	567	48	(	(	-LRB-
cord-306904-8iteddug	567	49	residues	residue	NNS
cord-306904-8iteddug	567	50	232	232	CD
cord-306904-8iteddug	567	51	-	-	HYPH
cord-306904-8iteddug	567	52	239	239	CD
cord-306904-8iteddug	567	53	)	)	-RRB-
cord-306904-8iteddug	567	54	.	.	.
cord-306904-8iteddug	568	1	One	one	CD
cord-306904-8iteddug	568	2	more	more	JJR
cord-306904-8iteddug	568	3	AiBS	AiBS	NNP
cord-306904-8iteddug	568	4	is	be	VBZ
cord-306904-8iteddug	568	5	predicted	predict	VBN
cord-306904-8iteddug	568	6	at	at	IN
cord-306904-8iteddug	568	7	residues	residue	NNS
cord-306904-8iteddug	568	8	171	171	CD
cord-306904-8iteddug	568	9	-	-	SYM
cord-306904-8iteddug	568	10	188	188	CD
cord-306904-8iteddug	568	11	.	.	.
cord-306904-8iteddug	569	1	Stark	Stark	NNP
cord-306904-8iteddug	569	2	et	et	FW
cord-306904-8iteddug	569	3	al	al	NNP
cord-306904-8iteddug	569	4	.	.	NNP
cord-306904-8iteddug	569	5	performed	perform	VBD
cord-306904-8iteddug	569	6	functional	functional	JJ
cord-306904-8iteddug	569	7	analysis	analysis	NN
cord-306904-8iteddug	569	8	of	of	IN
cord-306904-8iteddug	569	9	the	the	DT
cord-306904-8iteddug	569	10	important	important	JJ
cord-306904-8iteddug	569	11	human	human	JJ
cord-306904-8iteddug	569	12	chaperone	chaperone	NN
cord-306904-8iteddug	569	13	,	,	,
cord-306904-8iteddug	569	14	DnaJ	DnaJ	NNP
cord-306904-8iteddug	569	15	homolog	homolog	NN
cord-306904-8iteddug	569	16	subfamily	subfamily	NN
cord-306904-8iteddug	569	17	A	a	DT
cord-306904-8iteddug	569	18	member	member	NN
cord-306904-8iteddug	569	19	1	1	CD
cord-306904-8iteddug	569	20	(	(	-LRB-
cord-306904-8iteddug	569	21	DNAJA1	DNAJA1	NNP
cord-306904-8iteddug	569	22	)	)	-RRB-
cord-306904-8iteddug	569	23	,	,	,
cord-306904-8iteddug	569	24	and	and	CC
cord-306904-8iteddug	569	25	solved	solve	VBD
cord-306904-8iteddug	569	26	solution	solution	NN
cord-306904-8iteddug	569	27	structure	structure	NN
cord-306904-8iteddug	569	28	of	of	IN
cord-306904-8iteddug	569	29	its	-PRON-	PRP$
cord-306904-8iteddug	569	30	J	J	NNP
cord-306904-8iteddug	569	31	-	-	HYPH
cord-306904-8iteddug	569	32	domain	domain	NN
cord-306904-8iteddug	569	33	(	(	-LRB-
cord-306904-8iteddug	569	34	residues	residue	NNS
cord-306904-8iteddug	569	35	1	1	CD
cord-306904-8iteddug	569	36	-	-	SYM
cord-306904-8iteddug	569	37	67	67	CD
cord-306904-8iteddug	569	38	)	)	-RRB-
cord-306904-8iteddug	569	39	.	.	.
cord-306904-8iteddug	570	1	219	219	CD
cord-306904-8iteddug	570	2	Human	Human	NNP
cord-306904-8iteddug	570	3	DNAJA1	dnaja1	NN
cord-306904-8iteddug	570	4	has	have	VBZ
cord-306904-8iteddug	570	5	multiple	multiple	JJ
cord-306904-8iteddug	570	6	important	important	JJ
cord-306904-8iteddug	570	7	functions	function	NNS
cord-306904-8iteddug	570	8	and	and	CC
cord-306904-8iteddug	570	9	act	act	VB
cord-306904-8iteddug	570	10	as	as	IN
cord-306904-8iteddug	570	11	protein	protein	NN
cord-306904-8iteddug	570	12	chaperone	chaperone	NN
cord-306904-8iteddug	570	13	,	,	,
cord-306904-8iteddug	570	14	regulator	regulator	NN
cord-306904-8iteddug	570	15	of	of	IN
cord-306904-8iteddug	570	16	androgen	androgen	NN
cord-306904-8iteddug	570	17	receptor	receptor	NN
cord-306904-8iteddug	570	18	signaling	signaling	NN
cord-306904-8iteddug	570	19	,	,	,
cord-306904-8iteddug	570	20	and	and	CC
cord-306904-8iteddug	570	21	activator	activator	NN
cord-306904-8iteddug	570	22	of	of	IN
cord-306904-8iteddug	570	23	the	the	DT
cord-306904-8iteddug	570	24	DnaK	DnaK	NNP
cord-306904-8iteddug	570	25	protein	protein	NN
cord-306904-8iteddug	570	26	.	.	.
cord-306904-8iteddug	571	1	Furthermore	furthermore	RB
cord-306904-8iteddug	571	2	,	,	,
cord-306904-8iteddug	571	3	levels	level	NNS
cord-306904-8iteddug	571	4	of	of	IN
cord-306904-8iteddug	571	5	the	the	DT
cord-306904-8iteddug	571	6	human	human	JJ
cord-306904-8iteddug	571	7	DNAJA1	DNAJA1	NNS
cord-306904-8iteddug	571	8	serve	serve	VBP
cord-306904-8iteddug	571	9	as	as	IN
cord-306904-8iteddug	571	10	a	a	DT
cord-306904-8iteddug	571	11	biomarker	biomarker	NN
cord-306904-8iteddug	571	12	for	for	IN
cord-306904-8iteddug	571	13	pancreatic	pancreatic	JJ
cord-306904-8iteddug	571	14	cancer	cancer	NN
cord-306904-8iteddug	571	15	,	,	,
cord-306904-8iteddug	571	16	since	since	IN
cord-306904-8iteddug	571	17	the	the	DT
cord-306904-8iteddug	571	18	expression	expression	NN
cord-306904-8iteddug	571	19	of	of	IN
cord-306904-8iteddug	571	20	this	this	DT
cord-306904-8iteddug	571	21	protein	protein	NN
cord-306904-8iteddug	571	22	in	in	IN
cord-306904-8iteddug	571	23	pancreatic	pancreatic	JJ
cord-306904-8iteddug	571	24	cancer	cancer	NN
cord-306904-8iteddug	571	25	cells	cell	NNS
cord-306904-8iteddug	571	26	is	be	VBZ
cord-306904-8iteddug	571	27	downregulated	downregulate	VBN
cord-306904-8iteddug	571	28	fold5-	fold5-	JJ
cord-306904-8iteddug	571	29	.	.	.
cord-306904-8iteddug	572	1	220	220	CD
cord-306904-8iteddug	572	2	NMR	NMR	NNP
cord-306904-8iteddug	572	3	analysis	analysis	NN
cord-306904-8iteddug	572	4	revealed	reveal	VBD
cord-306904-8iteddug	572	5	that	that	IN
cord-306904-8iteddug	572	6	the	the	DT
cord-306904-8iteddug	572	7	structure	structure	NN
cord-306904-8iteddug	572	8	of	of	IN
cord-306904-8iteddug	572	9	the	the	DT
cord-306904-8iteddug	572	10	human	human	JJ
cord-306904-8iteddug	572	11	DNAJA1	dnaja1	FW
cord-306904-8iteddug	572	12	J	J	NNP
cord-306904-8iteddug	572	13	-	-	HYPH
cord-306904-8iteddug	572	14	domain	domain	NNP
cord-306904-8iteddug	572	15	consists	consist	VBZ
cord-306904-8iteddug	572	16	of	of	IN
cord-306904-8iteddug	572	17	4	4	CD
cord-306904-8iteddug	572	18	a	a	DT
cord-306904-8iteddug	572	19	-	-	:
cord-306904-8iteddug	572	20	helices	helix	NNS
cord-306904-8iteddug	572	21	,	,	,
cord-306904-8iteddug	572	22	residues	residue	VBZ
cord-306904-8iteddug	572	23	17	17	CD
cord-306904-8iteddug	572	24	-	-	SYM
cord-306904-8iteddug	572	25	21	21	CD
cord-306904-8iteddug	572	26	(	(	-LRB-
cord-306904-8iteddug	572	27	a1	a1	NNP
cord-306904-8iteddug	572	28	)	)	-RRB-
cord-306904-8iteddug	572	29	,	,	,
cord-306904-8iteddug	572	30	29	29	CD
cord-306904-8iteddug	572	31	-	-	SYM
cord-306904-8iteddug	572	32	42	42	CD
cord-306904-8iteddug	572	33	(	(	-LRB-
cord-306904-8iteddug	572	34	a2	a2	NNP
cord-306904-8iteddug	572	35	)	)	-RRB-
cord-306904-8iteddug	572	36	,	,	,
cord-306904-8iteddug	572	37	52	52	CD
cord-306904-8iteddug	572	38	-	-	SYM
cord-306904-8iteddug	572	39	65	65	CD
cord-306904-8iteddug	572	40	(	(	-LRB-
cord-306904-8iteddug	572	41	a3	a3	NNP
cord-306904-8iteddug	572	42	)	)	-RRB-
cord-306904-8iteddug	572	43	,	,	,
cord-306904-8iteddug	572	44	and	and	CC
cord-306904-8iteddug	572	45	68	68	CD
cord-306904-8iteddug	572	46	-	-	SYM
cord-306904-8iteddug	572	47	75	75	CD
cord-306904-8iteddug	572	48	(	(	-LRB-
cord-306904-8iteddug	572	49	a4	a4	NNP
cord-306904-8iteddug	572	50	)	)	-RRB-
cord-306904-8iteddug	572	51	(	(	-LRB-
cord-306904-8iteddug	572	52	see	see	VB
cord-306904-8iteddug	572	53	Fig	Fig	NNP
cord-306904-8iteddug	572	54	.	.	.
cord-306904-8iteddug	573	1	19A	19a	LS
cord-306904-8iteddug	573	2	;	;	:
cord-306904-8iteddug	573	3	PDB	PDB	NNP
cord-306904-8iteddug	573	4	ID	ID	NNP
cord-306904-8iteddug	573	5	:	:	:
cord-306904-8iteddug	573	6	2M6Y	2m6y	CD
cord-306904-8iteddug	573	7	)	)	-RRB-
cord-306904-8iteddug	573	8	.	.	.
cord-306904-8iteddug	574	1	219	219	CD
cord-306904-8iteddug	575	1	On	on	IN
cord-306904-8iteddug	575	2	the	the	DT
cord-306904-8iteddug	575	3	contrary	contrary	NN
cord-306904-8iteddug	575	4	,	,	,
cord-306904-8iteddug	575	5	the	the	DT
cord-306904-8iteddug	575	6	evaluation	evaluation	NN
cord-306904-8iteddug	575	7	of	of	IN
cord-306904-8iteddug	575	8	intrinsic	intrinsic	JJ
cord-306904-8iteddug	575	9	disorder	disorder	NN
cord-306904-8iteddug	575	10	propensity	propensity	NN
cord-306904-8iteddug	575	11	of	of	IN
cord-306904-8iteddug	575	12	the	the	DT
cord-306904-8iteddug	575	13	full	full	JJ
cord-306904-8iteddug	575	14	-	-	HYPH
cord-306904-8iteddug	575	15	length	length	NN
cord-306904-8iteddug	575	16	protein	protein	NN
cord-306904-8iteddug	575	17	suggested	suggest	VBD
cord-306904-8iteddug	575	18	that	that	IN
cord-306904-8iteddug	575	19	DNAJA1	dnaja1	XX
cord-306904-8iteddug	576	1	(	(	-LRB-
cord-306904-8iteddug	576	2	UniProt	UniProt	NNP
cord-306904-8iteddug	576	3	ID	ID	NNP
cord-306904-8iteddug	576	4	:	:	:
cord-306904-8iteddug	577	1	P31689	P31689	NNP
cord-306904-8iteddug	577	2	)	)	-RRB-
cord-306904-8iteddug	577	3	possesses	possess	VBZ
cord-306904-8iteddug	577	4	significant	significant	JJ
cord-306904-8iteddug	577	5	amount	amount	NN
cord-306904-8iteddug	577	6	of	of	IN
cord-306904-8iteddug	577	7	disorder	disorder	NN
cord-306904-8iteddug	577	8	throughout	throughout	IN
cord-306904-8iteddug	577	9	its	-PRON-	PRP$
cord-306904-8iteddug	577	10	N	n	CD
cord-306904-8iteddug	577	11	-	-	HYPH
cord-306904-8iteddug	577	12	and	and	CC
cord-306904-8iteddug	577	13	C	c	NN
cord-306904-8iteddug	577	14	-	-	HYPH
cord-306904-8iteddug	577	15	terminal	terminal	NN
cord-306904-8iteddug	577	16	tails	tail	NNS
cord-306904-8iteddug	577	17	(	(	-LRB-
cord-306904-8iteddug	577	18	see	see	VB
cord-306904-8iteddug	577	19	Fig	Fig	NNP
cord-306904-8iteddug	577	20	.	.	.
cord-306904-8iteddug	578	1	19B	19b	LS
cord-306904-8iteddug	578	2	)	)	-RRB-
cord-306904-8iteddug	578	3	.	.	.
cord-306904-8iteddug	579	1	Curiously	curiously	RB
cord-306904-8iteddug	579	2	,	,	,
cord-306904-8iteddug	579	3	by	by	IN
cord-306904-8iteddug	579	4	ANCHOR	anchor	NN
cord-306904-8iteddug	579	5	analysis	analysis	NN
cord-306904-8iteddug	579	6	,	,	,
cord-306904-8iteddug	579	7	there	there	EX
cord-306904-8iteddug	579	8	are	be	VBP
cord-306904-8iteddug	579	9	3	3	CD
cord-306904-8iteddug	579	10	disorderbased	disorderbased	JJ
cord-306904-8iteddug	579	11	binding	bind	VBG
cord-306904-8iteddug	579	12	sites	site	NNS
cord-306904-8iteddug	579	13	in	in	IN
cord-306904-8iteddug	579	14	DNAJA1	DNAJA1	NNP
cord-306904-8iteddug	579	15	,	,	,
cord-306904-8iteddug	579	16	residues	residue	VBZ
cord-306904-8iteddug	579	17	26	26	CD
cord-306904-8iteddug	579	18	-	-	SYM
cord-306904-8iteddug	579	19	31	31	CD
cord-306904-8iteddug	579	20	,	,	,
cord-306904-8iteddug	579	21	85	85	CD
cord-306904-8iteddug	579	22	-	-	SYM
cord-306904-8iteddug	579	23	93	93	CD
cord-306904-8iteddug	579	24	,	,	,
cord-306904-8iteddug	579	25	and	and	CC
cord-306904-8iteddug	579	26	392	392	CD
cord-306904-8iteddug	579	27	-	-	SYM
cord-306904-8iteddug	579	28	397	397	CD
cord-306904-8iteddug	579	29	,	,	,
cord-306904-8iteddug	579	30	with	with	IN
cord-306904-8iteddug	579	31	binding	bind	VBG
cord-306904-8iteddug	579	32	site	site	NN
cord-306904-8iteddug	579	33	#	#	$
cord-306904-8iteddug	579	34	2	2	CD
cord-306904-8iteddug	579	35	being	be	VBG
cord-306904-8iteddug	579	36	overlapped	overlap	VBN
cord-306904-8iteddug	579	37	with	with	IN
cord-306904-8iteddug	579	38	a2	a2	NNP
cord-306904-8iteddug	579	39	.	.	.
cord-306904-8iteddug	580	1	Structure	structure	NN
cord-306904-8iteddug	580	2	and	and	CC
cord-306904-8iteddug	580	3	functions	function	NNS
cord-306904-8iteddug	580	4	of	of	IN
cord-306904-8iteddug	580	5	the	the	DT
cord-306904-8iteddug	580	6	purinerich	purinerich	JJ
cord-306904-8iteddug	580	7	element	element	NN
cord-306904-8iteddug	580	8	binding	bind	VBG
cord-306904-8iteddug	580	9	protein	protein	NN
cord-306904-8iteddug	580	10	B	B	NNP
cord-306904-8iteddug	580	11	(	(	-LRB-
cord-306904-8iteddug	580	12	Purb	Purb	NNP
cord-306904-8iteddug	580	13	)	)	-RRB-
cord-306904-8iteddug	581	1	In	in	IN
cord-306904-8iteddug	581	2	a	a	DT
cord-306904-8iteddug	581	3	recent	recent	JJ
cord-306904-8iteddug	581	4	comprehensive	comprehensive	JJ
cord-306904-8iteddug	581	5	study	study	NN
cord-306904-8iteddug	581	6	,	,	,
cord-306904-8iteddug	581	7	Romora	Romora	NNP
cord-306904-8iteddug	581	8	et	et	NNP
cord-306904-8iteddug	581	9	al	al	NNP
cord-306904-8iteddug	581	10	.	.	NNP
cord-306904-8iteddug	581	11	showed	show	VBD
cord-306904-8iteddug	581	12	that	that	IN
cord-306904-8iteddug	581	13	the	the	DT
cord-306904-8iteddug	581	14	purine	purine	NN
cord-306904-8iteddug	581	15	-	-	HYPH
cord-306904-8iteddug	581	16	rich	rich	JJ
cord-306904-8iteddug	581	17	element	element	NN
cord-306904-8iteddug	581	18	binding	bind	VBG
cord-306904-8iteddug	581	19	protein	protein	NN
cord-306904-8iteddug	581	20	B	B	NNP
cord-306904-8iteddug	581	21	(	(	-LRB-
cord-306904-8iteddug	581	22	Purb	Purb	NNP
cord-306904-8iteddug	581	23	)	)	-RRB-
cord-306904-8iteddug	581	24	serves	serve	VBZ
cord-306904-8iteddug	581	25	as	as	IN
cord-306904-8iteddug	581	26	a	a	DT
cord-306904-8iteddug	581	27	suppressor	suppressor	NN
cord-306904-8iteddug	581	28	of	of	IN
cord-306904-8iteddug	581	29	myofibroblast	myofibroblast	JJ
cord-306904-8iteddug	581	30	differentiation	differentiation	NN
cord-306904-8iteddug	581	31	and	and	CC
cord-306904-8iteddug	581	32	ACTA2	ACTA2	NNP
cord-306904-8iteddug	581	33	repression	repression	NN
cord-306904-8iteddug	581	34	.	.	.
cord-306904-8iteddug	582	1	221	221	CD
cord-306904-8iteddug	582	2	Pura	Pura	NNP
cord-306904-8iteddug	582	3	and	and	CC
cord-306904-8iteddug	582	4	Purb	Purb	NNP
cord-306904-8iteddug	582	5	are	be	VBP
cord-306904-8iteddug	582	6	members	member	NNS
cord-306904-8iteddug	582	7	of	of	IN
cord-306904-8iteddug	582	8	a	a	DT
cord-306904-8iteddug	582	9	small	small	JJ
cord-306904-8iteddug	582	10	family	family	NN
cord-306904-8iteddug	582	11	of	of	IN
cord-306904-8iteddug	582	12	nucleic	nucleic	JJ
cord-306904-8iteddug	582	13	acid	acid	NN
cord-306904-8iteddug	582	14	-	-	HYPH
cord-306904-8iteddug	582	15	binding	bind	VBG
cord-306904-8iteddug	582	16	proteins	protein	NNS
cord-306904-8iteddug	582	17	that	that	WDT
cord-306904-8iteddug	582	18	interact	interact	VBP
cord-306904-8iteddug	582	19	with	with	IN
cord-306904-8iteddug	582	20	purine	purine	NN
cord-306904-8iteddug	582	21	-	-	HYPH
cord-306904-8iteddug	582	22	rich	rich	JJ
cord-306904-8iteddug	582	23	ssDNA	ssdna	NN
cord-306904-8iteddug	582	24	or	or	CC
cord-306904-8iteddug	582	25	RNA	RNA	NNP
cord-306904-8iteddug	582	26	sequences	sequence	NNS
cord-306904-8iteddug	582	27	homologous	homologous	JJ
cord-306904-8iteddug	582	28	to	to	IN
cord-306904-8iteddug	582	29	the	the	DT
cord-306904-8iteddug	582	30	so	so	RB
cord-306904-8iteddug	582	31	-	-	HYPH
cord-306904-8iteddug	582	32	called	call	VBN
cord-306904-8iteddug	582	33	PUR	pur	NN
cord-306904-8iteddug	582	34	element	element	NN
cord-306904-8iteddug	582	35	originally	originally	RB
cord-306904-8iteddug	582	36	described	describe	VBN
cord-306904-8iteddug	582	37	in	in	IN
cord-306904-8iteddug	582	38	eukaryotic	eukaryotic	JJ
cord-306904-8iteddug	582	39	gene	gene	NN
cord-306904-8iteddug	582	40	flanking	flank	VBG
cord-306904-8iteddug	582	41	regions	region	NNS
cord-306904-8iteddug	582	42	and	and	CC
cord-306904-8iteddug	582	43	origins	origin	NNS
cord-306904-8iteddug	582	44	of	of	IN
cord-306904-8iteddug	582	45	DNA	dna	NN
cord-306904-8iteddug	582	46	replication	replication	NN
cord-306904-8iteddug	582	47	.	.	.
cord-306904-8iteddug	583	1	[	[	-LRB-
cord-306904-8iteddug	583	2	222	222	CD
cord-306904-8iteddug	583	3	]	]	-RRB-
cord-306904-8iteddug	583	4	[	[	-LRB-
cord-306904-8iteddug	583	5	223	223	CD
cord-306904-8iteddug	583	6	]	]	-RRB-
cord-306904-8iteddug	584	1	[	[	-LRB-
cord-306904-8iteddug	584	2	224	224	CD
cord-306904-8iteddug	584	3	]	]	-RRB-
cord-306904-8iteddug	584	4	Figure	figure	NN
cord-306904-8iteddug	584	5	14D	14D	NNS
cord-306904-8iteddug	584	6	shows	show	VBZ
cord-306904-8iteddug	584	7	that	that	IN
cord-306904-8iteddug	584	8	human	human	JJ
cord-306904-8iteddug	584	9	Purb	Purb	NNP
cord-306904-8iteddug	584	10	protein	protein	NN
cord-306904-8iteddug	584	11	(	(	-LRB-
cord-306904-8iteddug	584	12	UniProt	UniProt	NNP
cord-306904-8iteddug	584	13	ID	ID	NNP
cord-306904-8iteddug	584	14	:	:	:
cord-306904-8iteddug	584	15	O35295	O35295	NNP
cord-306904-8iteddug	584	16	)	)	-RRB-
cord-306904-8iteddug	584	17	is	be	VBZ
cord-306904-8iteddug	584	18	predicted	predict	VBN
cord-306904-8iteddug	584	19	to	to	TO
cord-306904-8iteddug	584	20	possess	possess	VB
cord-306904-8iteddug	584	21	significant	significant	JJ
cord-306904-8iteddug	584	22	amount	amount	NN
cord-306904-8iteddug	584	23	of	of	IN
cord-306904-8iteddug	584	24	functionally	functionally	RB
cord-306904-8iteddug	584	25	important	important	JJ
cord-306904-8iteddug	584	26	intrinsic	intrinsic	JJ
cord-306904-8iteddug	584	27	disorder	disorder	NN
cord-306904-8iteddug	584	28	.	.	.
cord-306904-8iteddug	585	1	Importance	importance	NN
cord-306904-8iteddug	585	2	of	of	IN
cord-306904-8iteddug	585	3	the	the	DT
cord-306904-8iteddug	585	4	long	long	JJ
cord-306904-8iteddug	585	5	disordered	disordered	JJ
cord-306904-8iteddug	585	6	regions	region	NNS
cord-306904-8iteddug	585	7	in	in	IN
cord-306904-8iteddug	585	8	this	this	DT
cord-306904-8iteddug	585	9	protein	protein	NN
cord-306904-8iteddug	585	10	is	be	VBZ
cord-306904-8iteddug	585	11	supported	support	VBN
cord-306904-8iteddug	585	12	by	by	IN
cord-306904-8iteddug	585	13	finding	find	VBG
cord-306904-8iteddug	585	14	10	10	CD
cord-306904-8iteddug	585	15	AiBSs	AiBSs	NNP
cord-306904-8iteddug	585	16	(	(	-LRB-
cord-306904-8iteddug	585	17	residues	residue	NNS
cord-306904-8iteddug	585	18	1	1	CD
cord-306904-8iteddug	585	19	-	-	SYM
cord-306904-8iteddug	585	20	6	6	CD
cord-306904-8iteddug	585	21	,	,	,
cord-306904-8iteddug	585	22	18	18	CD
cord-306904-8iteddug	585	23	-	-	SYM
cord-306904-8iteddug	585	24	27	27	CD
cord-306904-8iteddug	585	25	,	,	,
cord-306904-8iteddug	585	26	47	47	CD
cord-306904-8iteddug	585	27	-	-	SYM
cord-306904-8iteddug	585	28	75	75	CD
cord-306904-8iteddug	585	29	,	,	,
cord-306904-8iteddug	585	30	87	87	CD
cord-306904-8iteddug	585	31	-	-	SYM
cord-306904-8iteddug	585	32	95	95	CD
cord-306904-8iteddug	585	33	,	,	,
cord-306904-8iteddug	585	34	99	99	CD
cord-306904-8iteddug	585	35	-	-	SYM
cord-306904-8iteddug	585	36	106	106	CD
cord-306904-8iteddug	585	37	,	,	,
cord-306904-8iteddug	585	38	135	135	CD
cord-306904-8iteddug	585	39	-	-	SYM
cord-306904-8iteddug	585	40	137	137	CD
cord-306904-8iteddug	585	41	,	,	,
cord-306904-8iteddug	585	42	142	142	CD
cord-306904-8iteddug	585	43	-	-	SYM
cord-306904-8iteddug	585	44	144	144	CD
cord-306904-8iteddug	585	45	,	,	,
cord-306904-8iteddug	585	46	186	186	CD
cord-306904-8iteddug	585	47	-	-	SYM
cord-306904-8iteddug	585	48	201	201	CD
cord-306904-8iteddug	585	49	,	,	,
cord-306904-8iteddug	585	50	243	243	CD
cord-306904-8iteddug	585	51	-	-	SYM
cord-306904-8iteddug	585	52	256	256	CD
cord-306904-8iteddug	585	53	,	,	,
cord-306904-8iteddug	585	54	and	and	CC
cord-306904-8iteddug	585	55	277	277	CD
cord-306904-8iteddug	585	56	-	-	SYM
cord-306904-8iteddug	585	57	287	287	CD
cord-306904-8iteddug	585	58	)	)	-RRB-
cord-306904-8iteddug	585	59	.	.	.
cord-306904-8iteddug	586	1	In	in	IN
cord-306904-8iteddug	586	2	agreement	agreement	NN
cord-306904-8iteddug	586	3	with	with	IN
cord-306904-8iteddug	586	4	these	these	DT
cord-306904-8iteddug	586	5	predictions	prediction	NNS
cord-306904-8iteddug	586	6	,	,	,
cord-306904-8iteddug	586	7	the	the	DT
cord-306904-8iteddug	586	8	authors	author	NNS
cord-306904-8iteddug	586	9	showed	show	VBD
cord-306904-8iteddug	586	10	that	that	IN
cord-306904-8iteddug	586	11	several	several	JJ
cord-306904-8iteddug	586	12	regions	region	NNS
cord-306904-8iteddug	586	13	of	of	IN
cord-306904-8iteddug	586	14	Purb	Purb	NNP
cord-306904-8iteddug	586	15	were	be	VBD
cord-306904-8iteddug	586	16	(	(	-LRB-
cord-306904-8iteddug	586	17	residues	residue	NNS
cord-306904-8iteddug	586	18	41	41	CD
cord-306904-8iteddug	586	19	-	-	SYM
cord-306904-8iteddug	586	20	112	112	CD
cord-306904-8iteddug	586	21	,	,	,
cord-306904-8iteddug	586	22	125	125	CD
cord-306904-8iteddug	586	23	-	-	SYM
cord-306904-8iteddug	586	24	210	210	CD
cord-306904-8iteddug	586	25	,	,	,
cord-306904-8iteddug	586	26	and	and	CC
cord-306904-8iteddug	586	27	125	125	CD
cord-306904-8iteddug	586	28	-	-	SYM
cord-306904-8iteddug	586	29	303	303	CD
cord-306904-8iteddug	586	30	)	)	-RRB-
cord-306904-8iteddug	586	31	were	be	VBD
cord-306904-8iteddug	586	32	intrinsically	intrinsically	RB
cord-306904-8iteddug	586	33	unstable	unstable	JJ
cord-306904-8iteddug	586	34	.	.	.
cord-306904-8iteddug	587	1	221	221	CD
cord-306904-8iteddug	588	1	The	the	DT
cord-306904-8iteddug	588	2	host	host	NN
cord-306904-8iteddug	588	3	restriction	restriction	NN
cord-306904-8iteddug	588	4	factor	factor	NN
cord-306904-8iteddug	588	5	tetherin	tetherin	XX
cord-306904-8iteddug	588	6	Hotter	hot	JJR
cord-306904-8iteddug	588	7	et	et	NNP
cord-306904-8iteddug	588	8	al	al	NNP
cord-306904-8iteddug	588	9	.	.	NNP
cord-306904-8iteddug	588	10	provided	provide	VBD
cord-306904-8iteddug	588	11	a	a	DT
cord-306904-8iteddug	588	12	comprehensive	comprehensive	JJ
cord-306904-8iteddug	588	13	review	review	NN
cord-306904-8iteddug	588	14	of	of	IN
cord-306904-8iteddug	588	15	the	the	DT
cord-306904-8iteddug	588	16	antiviral	antiviral	JJ
cord-306904-8iteddug	588	17	role	role	NN
cord-306904-8iteddug	588	18	of	of	IN
cord-306904-8iteddug	588	19	one	one	CD
cord-306904-8iteddug	588	20	of	of	IN
cord-306904-8iteddug	588	21	the	the	DT
cord-306904-8iteddug	588	22	host	host	NN
cord-306904-8iteddug	588	23	restriction	restriction	NN
cord-306904-8iteddug	588	24	factors	factor	NNS
cord-306904-8iteddug	588	25	(	(	-LRB-
cord-306904-8iteddug	588	26	i.e.	i.e.	FW
cord-306904-8iteddug	588	27	,	,	,
cord-306904-8iteddug	588	28	specific	specific	JJ
cord-306904-8iteddug	588	29	cellular	cellular	JJ
cord-306904-8iteddug	588	30	antiviral	antiviral	JJ
cord-306904-8iteddug	588	31	factors	factor	NNS
cord-306904-8iteddug	588	32	that	that	WDT
cord-306904-8iteddug	588	33	inhibit	inhibit	VBP
cord-306904-8iteddug	588	34	retroviral	retroviral	NN
cord-306904-8iteddug	588	35	replication	replication	NN
cord-306904-8iteddug	588	36	at	at	IN
cord-306904-8iteddug	588	37	different	different	JJ
cord-306904-8iteddug	588	38	steps	step	NNS
cord-306904-8iteddug	588	39	of	of	IN
cord-306904-8iteddug	588	40	the	the	DT
cord-306904-8iteddug	588	41	viral	viral	JJ
cord-306904-8iteddug	588	42	life	life	NN
cord-306904-8iteddug	588	43	cycle	cycle	NN
cord-306904-8iteddug	588	44	)	)	-RRB-
cord-306904-8iteddug	588	45	,	,	,
cord-306904-8iteddug	588	46	human	human	JJ
cord-306904-8iteddug	588	47	tetherin	tetherin	NNS
cord-306904-8iteddug	588	48	.	.	.
cord-306904-8iteddug	589	1	225	225	CD
cord-306904-8iteddug	590	1	Among	among	IN
cord-306904-8iteddug	590	2	various	various	JJ
cord-306904-8iteddug	590	3	antiviral	antiviral	JJ
cord-306904-8iteddug	590	4	mechanisms	mechanism	NNS
cord-306904-8iteddug	590	5	ascribed	ascribe	VBN
cord-306904-8iteddug	590	6	to	to	IN
cord-306904-8iteddug	590	7	tetherin	tetherin	NNP
cord-306904-8iteddug	590	8	are	be	VBP
cord-306904-8iteddug	590	9	the	the	DT
cord-306904-8iteddug	590	10	inhibition	inhibition	NN
cord-306904-8iteddug	590	11	of	of	IN
cord-306904-8iteddug	590	12	the	the	DT
cord-306904-8iteddug	590	13	release	release	NN
cord-306904-8iteddug	590	14	of	of	IN
cord-306904-8iteddug	590	15	diverse	diverse	JJ
cord-306904-8iteddug	590	16	enveloped	envelop	VBN
cord-306904-8iteddug	590	17	viruses	virus	NNS
cord-306904-8iteddug	590	18	by	by	IN
cord-306904-8iteddug	590	19	tethering	tether	VBG
cord-306904-8iteddug	590	20	them	-PRON-	PRP
cord-306904-8iteddug	590	21	to	to	IN
cord-306904-8iteddug	590	22	the	the	DT
cord-306904-8iteddug	590	23	cell	cell	NN
cord-306904-8iteddug	590	24	surface	surface	NN
cord-306904-8iteddug	590	25	,	,	,
cord-306904-8iteddug	590	26	induction	induction	NN
cord-306904-8iteddug	590	27	of	of	IN
cord-306904-8iteddug	590	28	an	an	DT
cord-306904-8iteddug	590	29	inflammatory	inflammatory	JJ
cord-306904-8iteddug	590	30	response	response	NN
cord-306904-8iteddug	590	31	,	,	,
cord-306904-8iteddug	590	32	activation	activation	NN
cord-306904-8iteddug	590	33	of	of	IN
cord-306904-8iteddug	590	34	NF	NF	NNP
cord-306904-8iteddug	590	35	-	-	HYPH
cord-306904-8iteddug	590	36	kB	kB	NNP
cord-306904-8iteddug	590	37	,	,	,
cord-306904-8iteddug	590	38	action	action	NN
cord-306904-8iteddug	590	39	as	as	IN
cord-306904-8iteddug	590	40	an	an	DT
cord-306904-8iteddug	590	41	innate	innate	JJ
cord-306904-8iteddug	590	42	immune	immune	JJ
cord-306904-8iteddug	590	43	sensor	sensor	NN
cord-306904-8iteddug	590	44	of	of	IN
cord-306904-8iteddug	590	45	viral	viral	JJ
cord-306904-8iteddug	590	46	infections	infection	NNS
cord-306904-8iteddug	590	47	,	,	,
cord-306904-8iteddug	590	48	activation	activation	NN
cord-306904-8iteddug	590	49	of	of	IN
cord-306904-8iteddug	590	50	immune	immune	JJ
cord-306904-8iteddug	590	51	response	response	NN
cord-306904-8iteddug	590	52	through	through	IN
cord-306904-8iteddug	590	53	interactions	interaction	NNS
cord-306904-8iteddug	590	54	with	with	IN
cord-306904-8iteddug	590	55	the	the	DT
cord-306904-8iteddug	590	56	immunoglobulin	immunoglobulin	NN
cord-306904-8iteddug	590	57	-	-	HYPH
cord-306904-8iteddug	590	58	like	like	JJ
cord-306904-8iteddug	590	59	transcript	transcript	NN
cord-306904-8iteddug	590	60	7	7	CD
cord-306904-8iteddug	591	1	(	(	-LRB-
cord-306904-8iteddug	591	2	ILT7	ILT7	NNP
cord-306904-8iteddug	591	3	,	,	,
cord-306904-8iteddug	591	4	LILRA4	LILRA4	NNP
cord-306904-8iteddug	591	5	)	)	-RRB-
cord-306904-8iteddug	591	6	.	.	.
cord-306904-8iteddug	592	1	225	225	CD
cord-306904-8iteddug	593	1	As	as	IN
cord-306904-8iteddug	593	2	commonly	commonly	RB
cord-306904-8iteddug	593	3	seen	see	VBN
cord-306904-8iteddug	593	4	in	in	IN
cord-306904-8iteddug	593	5	the	the	DT
cord-306904-8iteddug	593	6	virus	virus	NN
cord-306904-8iteddug	593	7	-	-	HYPH
cord-306904-8iteddug	593	8	host	host	NN
cord-306904-8iteddug	593	9	arm	arm	NN
cord-306904-8iteddug	593	10	race	race	NN
cord-306904-8iteddug	593	11	,	,	,
cord-306904-8iteddug	593	12	effective	effective	JJ
cord-306904-8iteddug	593	13	antiviral	antiviral	JJ
cord-306904-8iteddug	593	14	strategies	strategy	NNS
cord-306904-8iteddug	593	15	of	of	IN
cord-306904-8iteddug	593	16	the	the	DT
cord-306904-8iteddug	593	17	host	host	NN
cord-306904-8iteddug	593	18	are	be	VBP
cord-306904-8iteddug	593	19	counterbalanced	counterbalance	VBN
cord-306904-8iteddug	593	20	by	by	IN
cord-306904-8iteddug	593	21	the	the	DT
cord-306904-8iteddug	593	22	development	development	NN
cord-306904-8iteddug	593	23	of	of	IN
cord-306904-8iteddug	593	24	novel	novel	JJ
cord-306904-8iteddug	593	25	invasive	invasive	JJ
cord-306904-8iteddug	593	26	strategies	strategy	NNS
cord-306904-8iteddug	593	27	,	,	,
cord-306904-8iteddug	593	28	and	and	CC
cord-306904-8iteddug	593	29	various	various	JJ
cord-306904-8iteddug	593	30	viruses	virus	NNS
cord-306904-8iteddug	593	31	have	have	VBP
cord-306904-8iteddug	593	32	evolved	evolve	VBN
cord-306904-8iteddug	593	33	antagonists	antagonist	NNS
cord-306904-8iteddug	593	34	against	against	IN
cord-306904-8iteddug	593	35	this	this	DT
cord-306904-8iteddug	593	36	host	host	NN
cord-306904-8iteddug	593	37	restriction	restriction	NN
cord-306904-8iteddug	593	38	factor	factor	NN
cord-306904-8iteddug	593	39	,	,	,
cord-306904-8iteddug	593	40	such	such	JJ
cord-306904-8iteddug	593	41	as	as	IN
cord-306904-8iteddug	593	42	accessory	accessory	NN
cord-306904-8iteddug	593	43	HIV-1	HIV-1	NNP
cord-306904-8iteddug	593	44	(	(	-LRB-
cord-306904-8iteddug	593	45	human	human	JJ
cord-306904-8iteddug	593	46	immunodeficiency	immunodeficiency	NN
cord-306904-8iteddug	593	47	virus	virus	NN
cord-306904-8iteddug	593	48	type	type	NN
cord-306904-8iteddug	593	49	1	1	CD
cord-306904-8iteddug	593	50	)	)	-RRB-
cord-306904-8iteddug	594	1	Vpu	vpu	NN
cord-306904-8iteddug	594	2	protein	protein	NN
cord-306904-8iteddug	594	3	that	that	WDT
cord-306904-8iteddug	594	4	counteracts	counteract	VBZ
cord-306904-8iteddug	594	5	the	the	DT
cord-306904-8iteddug	594	6	effects	effect	NNS
cord-306904-8iteddug	594	7	of	of	IN
cord-306904-8iteddug	594	8	tetherin	tetherin	NNS
cord-306904-8iteddug	594	9	.	.	.
cord-306904-8iteddug	595	1	225	225	CD
cord-306904-8iteddug	595	2	Tetherin	Tetherin	NNP
cord-306904-8iteddug	595	3	is	be	VBZ
cord-306904-8iteddug	595	4	a	a	DT
cord-306904-8iteddug	595	5	type	type	NN
cord-306904-8iteddug	595	6	II	II	NNP
cord-306904-8iteddug	595	7	transmembrane	transmembrane	NN
cord-306904-8iteddug	595	8	protein	protein	NN
cord-306904-8iteddug	595	9	that	that	WDT
cord-306904-8iteddug	595	10	contains	contain	VBZ
cord-306904-8iteddug	595	11	both	both	CC
cord-306904-8iteddug	595	12	an	an	DT
cord-306904-8iteddug	595	13	N	n	CD
cord-306904-8iteddug	595	14	-	-	HYPH
cord-306904-8iteddug	595	15	terminal	terminal	NN
cord-306904-8iteddug	595	16	transmembrane	transmembrane	NN
cord-306904-8iteddug	595	17	region	region	NN
cord-306904-8iteddug	595	18	and	and	CC
cord-306904-8iteddug	595	19	a	a	DT
cord-306904-8iteddug	595	20	C	c	NN
cord-306904-8iteddug	595	21	-	-	HYPH
cord-306904-8iteddug	595	22	terminal	terminal	NN
cord-306904-8iteddug	595	23	glycosyl	glycosyl	NN
cord-306904-8iteddug	595	24	-	-	HYPH
cord-306904-8iteddug	595	25	phosphatidylinositol	phosphatidylinositol	JJ
cord-306904-8iteddug	595	26	(	(	-LRB-
cord-306904-8iteddug	595	27	GPI	GPI	NNP
cord-306904-8iteddug	595	28	)	)	-RRB-
cord-306904-8iteddug	595	29	anchor	anchor	NN
cord-306904-8iteddug	595	30	.	.	.
cord-306904-8iteddug	596	1	226	226	CD
cord-306904-8iteddug	597	1	Structurally	structurally	RB
cord-306904-8iteddug	597	2	,	,	,
cord-306904-8iteddug	597	3	human	human	JJ
cord-306904-8iteddug	597	4	tetherin	tetherin	NN
cord-306904-8iteddug	597	5	exists	exist	VBZ
cord-306904-8iteddug	597	6	as	as	IN
cord-306904-8iteddug	597	7	a	a	DT
cord-306904-8iteddug	597	8	disulfide	disulfide	RB
cord-306904-8iteddug	597	9	-	-	HYPH
cord-306904-8iteddug	597	10	linked	link	VBN
cord-306904-8iteddug	597	11	parallel	parallel	NN
cord-306904-8iteddug	597	12	homodimer	homodimer	NN
cord-306904-8iteddug	597	13	,	,	,
cord-306904-8iteddug	597	14	which	which	WDT
cord-306904-8iteddug	597	15	is	be	VBZ
cord-306904-8iteddug	597	16	formed	form	VBN
cord-306904-8iteddug	597	17	via	via	IN
cord-306904-8iteddug	597	18	the	the	DT
cord-306904-8iteddug	597	19	extracellular	extracellular	JJ
cord-306904-8iteddug	597	20	part	part	NN
cord-306904-8iteddug	597	21	that	that	WDT
cord-306904-8iteddug	597	22	is	be	VBZ
cord-306904-8iteddug	597	23	involved	involve	VBN
cord-306904-8iteddug	597	24	in	in	IN
cord-306904-8iteddug	597	25	the	the	DT
cord-306904-8iteddug	597	26	formation	formation	NN
cord-306904-8iteddug	597	27	of	of	IN
cord-306904-8iteddug	597	28	a	a	DT
cord-306904-8iteddug	597	29	canonical	canonical	JJ
cord-306904-8iteddug	597	30	coiled	coil	VBN
cord-306904-8iteddug	597	31	-	-	HYPH
cord-306904-8iteddug	597	32	coil	coil	NN
cord-306904-8iteddug	597	33	structure	structure	NN
cord-306904-8iteddug	597	34	,	,	,
cord-306904-8iteddug	597	35	where	where	WRB
cord-306904-8iteddug	597	36	a	a	DT
cord-306904-8iteddug	597	37	long	long	JJ
cord-306904-8iteddug	597	38	a	a	DT
cord-306904-8iteddug	597	39	-	-	HYPH
cord-306904-8iteddug	597	40	helix	helix	NN
cord-306904-8iteddug	597	41	contains	contain	VBZ
cord-306904-8iteddug	597	42	3	3	CD
cord-306904-8iteddug	597	43	cysteines	cysteine	NNS
cord-306904-8iteddug	597	44	that	that	WDT
cord-306904-8iteddug	597	45	form	form	VBP
cord-306904-8iteddug	597	46	disulfide	disulfide	NN
cord-306904-8iteddug	597	47	bonds	bond	NNS
cord-306904-8iteddug	597	48	with	with	IN
cord-306904-8iteddug	597	49	the	the	DT
cord-306904-8iteddug	597	50	corresponding	correspond	VBG
cord-306904-8iteddug	597	51	cysteines	cysteine	NNS
cord-306904-8iteddug	597	52	of	of	IN
cord-306904-8iteddug	597	53	a	a	DT
cord-306904-8iteddug	597	54	second	second	JJ
cord-306904-8iteddug	597	55	tetherin	tetherin	NN
cord-306904-8iteddug	597	56	molecule	molecule	NN
cord-306904-8iteddug	597	57	.	.	.
cord-306904-8iteddug	598	1	227	227	CD
cord-306904-8iteddug	599	1	It	-PRON-	PRP
cord-306904-8iteddug	599	2	is	be	VBZ
cord-306904-8iteddug	599	3	believed	believe	VBN
cord-306904-8iteddug	599	4	that	that	IN
cord-306904-8iteddug	599	5	tetherin	tetherin	NN
cord-306904-8iteddug	599	6	-	-	HYPH
cord-306904-8iteddug	599	7	caused	cause	VBN
cord-306904-8iteddug	599	8	viral	viral	JJ
cord-306904-8iteddug	599	9	retention	retention	NN
cord-306904-8iteddug	599	10	relies	rely	VBZ
cord-306904-8iteddug	599	11	on	on	IN
cord-306904-8iteddug	599	12	this	this	DT
cord-306904-8iteddug	599	13	unusual	unusual	JJ
cord-306904-8iteddug	599	14	architecture	architecture	NN
cord-306904-8iteddug	599	15	,	,	,
cord-306904-8iteddug	599	16	where	where	WRB
cord-306904-8iteddug	599	17	one	one	CD
cord-306904-8iteddug	599	18	transmembrane	transmembrane	NN
cord-306904-8iteddug	599	19	anchor	anchor	NN
cord-306904-8iteddug	599	20	may	may	MD
cord-306904-8iteddug	599	21	remain	remain	VB
cord-306904-8iteddug	599	22	in	in	IN
cord-306904-8iteddug	599	23	the	the	DT
cord-306904-8iteddug	599	24	cellular	cellular	JJ
cord-306904-8iteddug	599	25	plasma	plasma	NN
cord-306904-8iteddug	599	26	membrane	membrane	NN
cord-306904-8iteddug	599	27	,	,	,
cord-306904-8iteddug	599	28	whereas	whereas	IN
cord-306904-8iteddug	599	29	the	the	DT
cord-306904-8iteddug	599	30	other	other	JJ
cord-306904-8iteddug	599	31	is	be	VBZ
cord-306904-8iteddug	599	32	able	able	JJ
cord-306904-8iteddug	599	33	to	to	TO
cord-306904-8iteddug	599	34	stick	stick	VB
cord-306904-8iteddug	599	35	to	to	IN
cord-306904-8iteddug	599	36	the	the	DT
cord-306904-8iteddug	599	37	viral	viral	JJ
cord-306904-8iteddug	599	38	membrane	membrane	NN
cord-306904-8iteddug	599	39	.	.	.
cord-306904-8iteddug	600	1	228	228	CD
cord-306904-8iteddug	600	2	,	,	,
cord-306904-8iteddug	600	3	229	229	CD
cord-306904-8iteddug	600	4	Figure	figure	NN
cord-306904-8iteddug	600	5	20A	20a	NN
cord-306904-8iteddug	600	6	represents	represent	VBZ
cord-306904-8iteddug	600	7	the	the	DT
cord-306904-8iteddug	600	8	results	result	NNS
cord-306904-8iteddug	600	9	of	of	IN
cord-306904-8iteddug	600	10	the	the	DT
cord-306904-8iteddug	600	11	multi	multi	JJ
cord-306904-8iteddug	600	12	-	-	JJ
cord-306904-8iteddug	600	13	tool	tool	JJ
cord-306904-8iteddug	600	14	disorder	disorder	NN
cord-306904-8iteddug	600	15	predictions	prediction	NNS
cord-306904-8iteddug	600	16	for	for	IN
cord-306904-8iteddug	600	17	human	human	JJ
cord-306904-8iteddug	600	18	tetherin	tetherin	NNS
cord-306904-8iteddug	600	19	(	(	-LRB-
cord-306904-8iteddug	600	20	also	also	RB
cord-306904-8iteddug	600	21	known	know	VBN
cord-306904-8iteddug	600	22	as	as	IN
cord-306904-8iteddug	600	23	bone	bone	NN
cord-306904-8iteddug	600	24	marrow	marrow	NN
cord-306904-8iteddug	600	25	stromal	stromal	NN
cord-306904-8iteddug	600	26	antigen	antigen	NN
cord-306904-8iteddug	600	27	,	,	,
cord-306904-8iteddug	600	28	UniProt	UniProt	NNP
cord-306904-8iteddug	600	29	ID	ID	NNP
cord-306904-8iteddug	600	30	:	:	:
cord-306904-8iteddug	600	31	Q10589	Q10589	NNP
cord-306904-8iteddug	600	32	)	)	-RRB-
cord-306904-8iteddug	600	33	and	and	CC
cord-306904-8iteddug	600	34	shows	show	VBZ
cord-306904-8iteddug	600	35	that	that	IN
cord-306904-8iteddug	600	36	this	this	DT
cord-306904-8iteddug	600	37	protein	protein	NN
cord-306904-8iteddug	600	38	is	be	VBZ
cord-306904-8iteddug	600	39	expected	expect	VBN
cord-306904-8iteddug	600	40	to	to	TO
cord-306904-8iteddug	600	41	be	be	VB
cord-306904-8iteddug	600	42	mostly	mostly	RB
cord-306904-8iteddug	600	43	disordered	disordered	JJ
cord-306904-8iteddug	600	44	.	.	.
cord-306904-8iteddug	601	1	This	this	DT
cord-306904-8iteddug	601	2	is	be	VBZ
cord-306904-8iteddug	601	3	not	not	RB
cord-306904-8iteddug	601	4	a	a	DT
cord-306904-8iteddug	601	5	very	very	RB
cord-306904-8iteddug	601	6	surprising	surprising	JJ
cord-306904-8iteddug	601	7	observation	observation	NN
cord-306904-8iteddug	601	8	since	since	IN
cord-306904-8iteddug	601	9	coiled	coil	VBN
cord-306904-8iteddug	601	10	-	-	HYPH
cord-306904-8iteddug	601	11	coil	coil	NN
cord-306904-8iteddug	601	12	proteins	protein	NNS
cord-306904-8iteddug	601	13	are	be	VBP
cord-306904-8iteddug	601	14	expected	expect	VBN
cord-306904-8iteddug	601	15	to	to	TO
cord-306904-8iteddug	601	16	be	be	VB
cord-306904-8iteddug	601	17	intrinsically	intrinsically	RB
cord-306904-8iteddug	601	18	disordered	disordered	JJ
cord-306904-8iteddug	601	19	in	in	IN
cord-306904-8iteddug	601	20	their	-PRON-	PRP$
cord-306904-8iteddug	601	21	monomeric	monomeric	JJ
cord-306904-8iteddug	601	22	states	state	NNS
cord-306904-8iteddug	601	23	and	and	CC
cord-306904-8iteddug	601	24	fold	fold	VB
cord-306904-8iteddug	601	25	to	to	IN
cord-306904-8iteddug	601	26	a	a	DT
cord-306904-8iteddug	601	27	helical	helical	JJ
cord-306904-8iteddug	601	28	structure	structure	NN
cord-306904-8iteddug	601	29	at	at	IN
cord-306904-8iteddug	601	30	the	the	DT
cord-306904-8iteddug	601	31	formation	formation	NN
cord-306904-8iteddug	601	32	of	of	IN
cord-306904-8iteddug	601	33	coiled	coiled	JJ
cord-306904-8iteddug	601	34	-	-	HYPH
cord-306904-8iteddug	601	35	coil	coil	NN
cord-306904-8iteddug	601	36	structure	structure	NN
cord-306904-8iteddug	601	37	caused	cause	VBN
cord-306904-8iteddug	601	38	by	by	IN
cord-306904-8iteddug	601	39	the	the	DT
cord-306904-8iteddug	601	40	interaction	interaction	NN
cord-306904-8iteddug	601	41	with	with	IN
cord-306904-8iteddug	601	42	corresponding	correspond	VBG
cord-306904-8iteddug	601	43	partners	partner	NNS
cord-306904-8iteddug	601	44	.	.	.
cord-306904-8iteddug	602	1	230	230	CD
cord-306904-8iteddug	602	2	Cyclin	Cyclin	NNP
cord-306904-8iteddug	602	3	D1	D1	NNP
cord-306904-8iteddug	602	4	/	/	SYM
cord-306904-8iteddug	602	5	Cdk2	Cdk2	NNP
cord-306904-8iteddug	602	6	complex	complex	JJ
cord-306904-8iteddug	603	1	To	to	TO
cord-306904-8iteddug	603	2	clarify	clarify	VB
cord-306904-8iteddug	603	3	some	some	DT
cord-306904-8iteddug	603	4	uncertainties	uncertainty	NNS
cord-306904-8iteddug	603	5	in	in	IN
cord-306904-8iteddug	603	6	previous	previous	JJ
cord-306904-8iteddug	603	7	studies	study	NNS
cord-306904-8iteddug	603	8	regarding	regard	VBG
cord-306904-8iteddug	603	9	formation	formation	NN
cord-306904-8iteddug	603	10	and	and	CC
cord-306904-8iteddug	603	11	activities	activity	NNS
cord-306904-8iteddug	603	12	of	of	IN
cord-306904-8iteddug	603	13	the	the	DT
cord-306904-8iteddug	603	14	cyclin	cyclin	NN
cord-306904-8iteddug	603	15	D1	d1	NN
cord-306904-8iteddug	603	16	/	/	,
cord-306904-8iteddug	603	17	cyclin	cyclin	NN
cord-306904-8iteddug	603	18	-	-	HYPH
cord-306904-8iteddug	603	19	dependent	dependent	JJ
cord-306904-8iteddug	603	20	kinase	kinase	NN
cord-306904-8iteddug	603	21	2	2	CD
cord-306904-8iteddug	603	22	(	(	-LRB-
cord-306904-8iteddug	603	23	Cdk2	Cdk2	NNP
cord-306904-8iteddug	603	24	)	)	-RRB-
cord-306904-8iteddug	603	25	complexes	complex	NNS
cord-306904-8iteddug	603	26	Jahn	Jahn	NNP
cord-306904-8iteddug	603	27	et	et	NNP
cord-306904-8iteddug	603	28	al	al	NNP
cord-306904-8iteddug	603	29	.	.	.
cord-306904-8iteddug	604	1	utilized	utilize	VBN
cord-306904-8iteddug	604	2	a	a	DT
cord-306904-8iteddug	604	3	novel	novel	JJ
cord-306904-8iteddug	604	4	p21-PCNA	p21-PCNA	NNPS
cord-306904-8iteddug	604	5	fusion	fusion	NN
cord-306904-8iteddug	604	6	protein	protein	NN
cord-306904-8iteddug	604	7	and	and	CC
cord-306904-8iteddug	604	8	p21	p21	NN
cord-306904-8iteddug	604	9	mutant	mutant	JJ
cord-306904-8iteddug	604	10	proteins	protein	NNS
cord-306904-8iteddug	604	11	to	to	TO
cord-306904-8iteddug	604	12	understand	understand	VB
cord-306904-8iteddug	604	13	the	the	DT
cord-306904-8iteddug	604	14	mechanisms	mechanism	NNS
cord-306904-8iteddug	604	15	of	of	IN
cord-306904-8iteddug	604	16	the	the	DT
cord-306904-8iteddug	604	17	cyclin	cyclin	NN
cord-306904-8iteddug	604	18	D1	D1	NNP
cord-306904-8iteddug	604	19	/	/	SYM
cord-306904-8iteddug	604	20	Cdk2	cdk2	JJ
cord-306904-8iteddug	604	21	complex	complex	JJ
cord-306904-8iteddug	604	22	formation	formation	NN
cord-306904-8iteddug	604	23	.	.	.
cord-306904-8iteddug	605	1	231	231	CD
cord-306904-8iteddug	606	1	The	the	DT
cord-306904-8iteddug	606	2	authors	author	NNS
cord-306904-8iteddug	606	3	show	show	VBP
cord-306904-8iteddug	606	4	that	that	IN
cord-306904-8iteddug	606	5	p21	p21	NN
cord-306904-8iteddug	606	6	serves	serve	VBZ
cord-306904-8iteddug	606	7	as	as	IN
cord-306904-8iteddug	606	8	an	an	DT
cord-306904-8iteddug	606	9	important	important	JJ
cord-306904-8iteddug	606	10	scaffolding	scaffolding	NN
cord-306904-8iteddug	606	11	protein	protein	NN
cord-306904-8iteddug	606	12	,	,	,
cord-306904-8iteddug	606	13	which	which	WDT
cord-306904-8iteddug	606	14	is	be	VBZ
cord-306904-8iteddug	606	15	required	require	VBN
cord-306904-8iteddug	606	16	for	for	IN
cord-306904-8iteddug	606	17	the	the	DT
cord-306904-8iteddug	606	18	formation	formation	NN
cord-306904-8iteddug	606	19	of	of	IN
cord-306904-8iteddug	606	20	the	the	DT
cord-306904-8iteddug	606	21	functional	functional	JJ
cord-306904-8iteddug	606	22	cyclin	cyclin	NN
cord-306904-8iteddug	606	23	D1	D1	NNP
cord-306904-8iteddug	606	24	/	/	SYM
cord-306904-8iteddug	606	25	Cdk2	Cdk2	NNP
cord-306904-8iteddug	606	26	complex	complex	NN
cord-306904-8iteddug	606	27	,	,	,
cord-306904-8iteddug	606	28	since	since	IN
cord-306904-8iteddug	606	29	cyclin	cyclin	NN
cord-306904-8iteddug	606	30	D1	D1	NNP
cord-306904-8iteddug	606	31	and	and	CC
cord-306904-8iteddug	606	32	Cdk2	Cdk2	NNP
cord-306904-8iteddug	606	33	failing	fail	VBG
cord-306904-8iteddug	606	34	to	to	TO
cord-306904-8iteddug	606	35	complex	complex	VB
cord-306904-8iteddug	606	36	in	in	IN
cord-306904-8iteddug	606	37	its	-PRON-	PRP$
cord-306904-8iteddug	606	38	absence	absence	NN
cord-306904-8iteddug	606	39	.	.	.
cord-306904-8iteddug	607	1	231	231	CD
cord-306904-8iteddug	607	2	Figure	figure	NN
cord-306904-8iteddug	607	3	20B	20b	NN
cord-306904-8iteddug	607	4	shows	show	VBZ
cord-306904-8iteddug	607	5	that	that	IN
cord-306904-8iteddug	607	6	the	the	DT
cord-306904-8iteddug	607	7	scaffolding	scaffold	VBG
cord-306904-8iteddug	607	8	protein	protein	NN
cord-306904-8iteddug	607	9	p21	p21	NN
cord-306904-8iteddug	607	10	(	(	-LRB-
cord-306904-8iteddug	607	11	which	which	WDT
cord-306904-8iteddug	607	12	is	be	VBZ
cord-306904-8iteddug	607	13	a	a	DT
cord-306904-8iteddug	607	14	cyclin	cyclin	NN
cord-306904-8iteddug	607	15	-	-	HYPH
cord-306904-8iteddug	607	16	dependent	dependent	JJ
cord-306904-8iteddug	607	17	kinase	kinase	NN
cord-306904-8iteddug	607	18	inhibitor	inhibitor	NN
cord-306904-8iteddug	607	19	1	1	CD
cord-306904-8iteddug	607	20	,	,	,
cord-306904-8iteddug	607	21	UniProt	UniProt	NNP
cord-306904-8iteddug	607	22	ID	ID	NNP
cord-306904-8iteddug	607	23	:	:	:
cord-306904-8iteddug	607	24	P38936	P38936	NNP
cord-306904-8iteddug	607	25	)	)	-RRB-
cord-306904-8iteddug	607	26	is	be	VBZ
cord-306904-8iteddug	607	27	predicted	predict	VBN
cord-306904-8iteddug	607	28	to	to	TO
cord-306904-8iteddug	607	29	be	be	VB
cord-306904-8iteddug	607	30	mostly	mostly	RB
cord-306904-8iteddug	607	31	disordered	disordered	JJ
cord-306904-8iteddug	607	32	and	and	CC
cord-306904-8iteddug	607	33	packed	pack	VBN
cord-306904-8iteddug	607	34	with	with	IN
cord-306904-8iteddug	607	35	disorder	disorder	NN
cord-306904-8iteddug	607	36	-	-	HYPH
cord-306904-8iteddug	607	37	based	base	VBN
cord-306904-8iteddug	607	38	binding	binding	NN
cord-306904-8iteddug	607	39	sites	site	NNS
cord-306904-8iteddug	607	40	.	.	.
cord-306904-8iteddug	608	1	In	in	IN
cord-306904-8iteddug	608	2	fact	fact	NN
cord-306904-8iteddug	608	3	,	,	,
cord-306904-8iteddug	608	4	there	there	EX
cord-306904-8iteddug	608	5	are	be	VBP
cord-306904-8iteddug	608	6	5	5	CD
cord-306904-8iteddug	608	7	AiBSs	aibs	NNS
cord-306904-8iteddug	608	8	in	in	IN
cord-306904-8iteddug	608	9	this	this	DT
cord-306904-8iteddug	608	10	relatively	relatively	RB
cord-306904-8iteddug	608	11	small	small	JJ
cord-306904-8iteddug	608	12	protein	protein	NN
cord-306904-8iteddug	608	13	,	,	,
cord-306904-8iteddug	608	14	residues	residue	VBZ
cord-306904-8iteddug	608	15	36	36	CD
cord-306904-8iteddug	608	16	-	-	SYM
cord-306904-8iteddug	608	17	41	41	CD
cord-306904-8iteddug	608	18	,	,	,
cord-306904-8iteddug	608	19	68	68	CD
cord-306904-8iteddug	608	20	-	-	SYM
cord-306904-8iteddug	608	21	79	79	CD
cord-306904-8iteddug	608	22	,	,	,
cord-306904-8iteddug	608	23	100	100	CD
cord-306904-8iteddug	608	24	-	-	SYM
cord-306904-8iteddug	608	25	105	105	CD
cord-306904-8iteddug	608	26	,	,	,
cord-306904-8iteddug	608	27	109	109	CD
cord-306904-8iteddug	608	28	-	-	SYM
cord-306904-8iteddug	608	29	123	123	CD
cord-306904-8iteddug	608	30	,	,	,
cord-306904-8iteddug	608	31	and	and	CC
cord-306904-8iteddug	608	32	145	145	CD
cord-306904-8iteddug	608	33	-	-	SYM
cord-306904-8iteddug	608	34	164	164	CD
cord-306904-8iteddug	608	35	.	.	.
cord-306904-8iteddug	609	1	Using	use	VBG
cord-306904-8iteddug	609	2	this	this	DT
cord-306904-8iteddug	609	3	approach	approach	NN
cord-306904-8iteddug	609	4	,	,	,
cord-306904-8iteddug	609	5	the	the	DT
cord-306904-8iteddug	609	6	authors	author	NNS
cord-306904-8iteddug	609	7	were	be	VBD
cord-306904-8iteddug	609	8	able	able	JJ
cord-306904-8iteddug	609	9	to	to	TO
cord-306904-8iteddug	609	10	identify	identify	VB
cord-306904-8iteddug	609	11	a	a	DT
cord-306904-8iteddug	609	12	novel	novel	NN
cord-306904-8iteddug	609	13	Cdk2	Cdk2	NNP
cord-306904-8iteddug	609	14	substrate	substrate	NN
cord-306904-8iteddug	609	15	,	,	,
cord-306904-8iteddug	609	16	polypyrimidine	polypyrimidine	JJ
cord-306904-8iteddug	609	17	tract	tract	NN
cord-306904-8iteddug	609	18	binding	bind	VBG
cord-306904-8iteddug	609	19	protein	protein	NN
cord-306904-8iteddug	609	20	-	-	HYPH
cord-306904-8iteddug	609	21	associated	associate	VBN
cord-306904-8iteddug	609	22	splicing	splicing	NN
cord-306904-8iteddug	609	23	factor	factor	NN
cord-306904-8iteddug	609	24	(	(	-LRB-
cord-306904-8iteddug	609	25	PSF	PSF	NNP
cord-306904-8iteddug	609	26	)	)	-RRB-
cord-306904-8iteddug	609	27	.	.	.
cord-306904-8iteddug	610	1	Figure	figure	NN
cord-306904-8iteddug	610	2	20C	20c	CD
cord-306904-8iteddug	610	3	shows	show	VBZ
cord-306904-8iteddug	610	4	that	that	IN
cord-306904-8iteddug	610	5	PSF	psf	NN
cord-306904-8iteddug	610	6	(	(	-LRB-
cord-306904-8iteddug	610	7	UniProt	UniProt	NNP
cord-306904-8iteddug	610	8	ID	ID	NNP
cord-306904-8iteddug	610	9	:	:	:
cord-306904-8iteddug	610	10	P23246	P23246	NNP
cord-306904-8iteddug	610	11	)	)	-RRB-
cord-306904-8iteddug	610	12	is	be	VBZ
cord-306904-8iteddug	610	13	predicted	predict	VBN
cord-306904-8iteddug	610	14	to	to	TO
cord-306904-8iteddug	610	15	have	have	VB
cord-306904-8iteddug	610	16	highly	highly	RB
cord-306904-8iteddug	610	17	disordered	disordered	JJ
cord-306904-8iteddug	610	18	tails	tail	NNS
cord-306904-8iteddug	610	19	.	.	.
cord-306904-8iteddug	611	1	ANCHOR	anchor	NN
cord-306904-8iteddug	611	2	analysis	analysis	NN
cord-306904-8iteddug	611	3	15	15	CD
cord-306904-8iteddug	612	1	,	,	,
cord-306904-8iteddug	612	2	16	16	CD
cord-306904-8iteddug	612	3	revealed	reveal	VBD
cord-306904-8iteddug	612	4	that	that	IN
cord-306904-8iteddug	612	5	intrinsic	intrinsic	JJ
cord-306904-8iteddug	612	6	disorder	disorder	NN
cord-306904-8iteddug	612	7	is	be	VBZ
cord-306904-8iteddug	612	8	crucial	crucial	JJ
cord-306904-8iteddug	612	9	for	for	IN
cord-306904-8iteddug	612	10	the	the	DT
cord-306904-8iteddug	612	11	PSF	PSF	NNP
cord-306904-8iteddug	612	12	Human	Human	NNP
cord-306904-8iteddug	612	13	and	and	CC
cord-306904-8iteddug	612	14	mouse	mouse	NN
cord-306904-8iteddug	612	15	apolipoproteins	apolipoprotein	NNS
cord-306904-8iteddug	613	1	A	a	LS
cord-306904-8iteddug	613	2	-	-	:
cord-306904-8iteddug	613	3	I	I	NNP
cord-306904-8iteddug	613	4	Nguen	Nguen	NNP
cord-306904-8iteddug	613	5	et	et	NNP
cord-306904-8iteddug	613	6	al	al	NNP
cord-306904-8iteddug	613	7	.	.	.
cord-306904-8iteddug	613	8	analyzed	analyze	VBD
cord-306904-8iteddug	613	9	mechanistic	mechanistic	JJ
cord-306904-8iteddug	613	10	peculiarities	peculiarity	NNS
cord-306904-8iteddug	613	11	of	of	IN
cord-306904-8iteddug	613	12	the	the	DT
cord-306904-8iteddug	613	13	interaction	interaction	NN
cord-306904-8iteddug	613	14	between	between	IN
cord-306904-8iteddug	613	15	the	the	DT
cord-306904-8iteddug	613	16	high	high	JJ
cord-306904-8iteddug	613	17	density	density	NN
cord-306904-8iteddug	613	18	lipoprotein	lipoprotein	NN
cord-306904-8iteddug	613	19	(	(	-LRB-
cord-306904-8iteddug	613	20	HDL	HDL	NNP
cord-306904-8iteddug	613	21	)	)	-RRB-
cord-306904-8iteddug	613	22	particles	particle	NNS
cord-306904-8iteddug	613	23	and	and	CC
cord-306904-8iteddug	613	24	human	human	JJ
cord-306904-8iteddug	613	25	or	or	CC
cord-306904-8iteddug	613	26	mouse	mouse	NN
cord-306904-8iteddug	614	1	apolipoprotein	apolipoprotein	NNP
cord-306904-8iteddug	614	2	A	A	NNP
cord-306904-8iteddug	615	1	-I	-I	NFP
cord-306904-8iteddug	615	2	(	(	-LRB-
cord-306904-8iteddug	615	3	ApoA	ApoA	NNP
cord-306904-8iteddug	615	4	-	-	HYPH
cord-306904-8iteddug	615	5	I	I	NNP
cord-306904-8iteddug	615	6	)	)	-RRB-
cord-306904-8iteddug	615	7	.	.	.
cord-306904-8iteddug	616	1	232	232	CD
cord-306904-8iteddug	617	1	The	the	DT
cord-306904-8iteddug	617	2	authors	author	NNS
cord-306904-8iteddug	617	3	established	establish	VBD
cord-306904-8iteddug	617	4	that	that	IN
cord-306904-8iteddug	617	5	the	the	DT
cord-306904-8iteddug	617	6	C	C	NNP
cord-306904-8iteddug	617	7	-	-	HYPH
cord-306904-8iteddug	617	8	terminal	terminal	NN
cord-306904-8iteddug	617	9	domains	domain	NNS
cord-306904-8iteddug	617	10	(	(	-LRB-
cord-306904-8iteddug	617	11	CTDs	CTDs	NNP
cord-306904-8iteddug	617	12	)	)	-RRB-
cord-306904-8iteddug	617	13	of	of	IN
cord-306904-8iteddug	617	14	human	human	NN
cord-306904-8iteddug	617	15	and	and	CC
cord-306904-8iteddug	617	16	mouse	mouse	NN
cord-306904-8iteddug	617	17	ApoA	ApoA	NNP
cord-306904-8iteddug	617	18	-	-	HYPH
cord-306904-8iteddug	617	19	I	-PRON-	PRP
cord-306904-8iteddug	617	20	proteins	protein	NNS
cord-306904-8iteddug	617	21	are	be	VBP
cord-306904-8iteddug	617	22	the	the	DT
cord-306904-8iteddug	617	23	major	major	JJ
cord-306904-8iteddug	617	24	players	player	NNS
cord-306904-8iteddug	617	25	facilitating	facilitate	VBG
cord-306904-8iteddug	617	26	interactions	interaction	NNS
cord-306904-8iteddug	617	27	of	of	IN
cord-306904-8iteddug	617	28	these	these	DT
cord-306904-8iteddug	617	29	proteins	protein	NNS
cord-306904-8iteddug	617	30	with	with	IN
cord-306904-8iteddug	617	31	HDL	HDL	NNP
cord-306904-8iteddug	617	32	.	.	.
cord-306904-8iteddug	618	1	Curiously	curiously	RB
cord-306904-8iteddug	618	2	,	,	,
cord-306904-8iteddug	618	3	human	human	JJ
cord-306904-8iteddug	618	4	CTD	CTD	NNP
cord-306904-8iteddug	618	5	,	,	,
cord-306904-8iteddug	618	6	being	be	VBG
cord-306904-8iteddug	618	7	a	a	DT
cord-306904-8iteddug	618	8	bit	bit	NN
cord-306904-8iteddug	618	9	more	more	RBR
cord-306904-8iteddug	618	10	hydrophobic	hydrophobic	JJ
cord-306904-8iteddug	618	11	than	than	IN
cord-306904-8iteddug	618	12	mouse	mouse	NN
cord-306904-8iteddug	618	13	CTD	CTD	NNP
cord-306904-8iteddug	618	14	,	,	,
cord-306904-8iteddug	618	15	binds	bind	VBZ
cord-306904-8iteddug	618	16	to	to	IN
cord-306904-8iteddug	618	17	the	the	DT
cord-306904-8iteddug	618	18	HDL	HDL	NNP
cord-306904-8iteddug	618	19	particle	particle	NN
cord-306904-8iteddug	618	20	with	with	IN
cord-306904-8iteddug	618	21	higher	high	JJR
cord-306904-8iteddug	618	22	affinity	affinity	NN
cord-306904-8iteddug	618	23	.	.	.
cord-306904-8iteddug	619	1	On	on	IN
cord-306904-8iteddug	619	2	the	the	DT
cord-306904-8iteddug	619	3	other	other	JJ
cord-306904-8iteddug	619	4	hand	hand	NN
cord-306904-8iteddug	619	5	,	,	,
cord-306904-8iteddug	619	6	the	the	DT
cord-306904-8iteddug	619	7	isolated	isolated	JJ
cord-306904-8iteddug	619	8	N	n	CD
cord-306904-8iteddug	619	9	-	-	HYPH
cord-306904-8iteddug	619	10	terminal	terminal	JJ
cord-306904-8iteddug	619	11	helix	helix	NN
cord-306904-8iteddug	619	12	bundle	bundle	NN
cord-306904-8iteddug	619	13	domains	domain	NNS
cord-306904-8iteddug	619	14	(	(	-LRB-
cord-306904-8iteddug	619	15	residues	residue	NNS
cord-306904-8iteddug	619	16	1	1	CD
cord-306904-8iteddug	619	17	-	-	SYM
cord-306904-8iteddug	619	18	190	190	CD
cord-306904-8iteddug	619	19	)	)	-RRB-
cord-306904-8iteddug	619	20	of	of	IN
cord-306904-8iteddug	619	21	human	human	NN
cord-306904-8iteddug	619	22	and	and	CC
cord-306904-8iteddug	619	23	mouse	mouse	NN
cord-306904-8iteddug	619	24	ApoA	ApoA	NNP
cord-306904-8iteddug	619	25	-	-	HYPH
cord-306904-8iteddug	619	26	I	-PRON-	PRP
cord-306904-8iteddug	619	27	proteins	protein	NNS
cord-306904-8iteddug	619	28	binds	bind	VBZ
cord-306904-8iteddug	619	29	HDL	HDL	NNP
cord-306904-8iteddug	619	30	poorly	poorly	RB
cord-306904-8iteddug	619	31	.	.	.
cord-306904-8iteddug	620	1	232	232	CD
cord-306904-8iteddug	621	1	ApoA	ApoA	NNP
cord-306904-8iteddug	621	2	-	-	HYPH
cord-306904-8iteddug	621	3	I	-PRON-	PRP
cord-306904-8iteddug	621	4	stabilizes	stabilize	VBZ
cord-306904-8iteddug	621	5	discoidal	discoidal	JJ
cord-306904-8iteddug	621	6	HDL	hdl	NN
cord-306904-8iteddug	621	7	particles	particle	NNS
cord-306904-8iteddug	621	8	by	by	IN
cord-306904-8iteddug	621	9	forming	form	VBG
cord-306904-8iteddug	621	10	a	a	DT
cord-306904-8iteddug	621	11	double	double	JJ
cord-306904-8iteddug	621	12	-	-	HYPH
cord-306904-8iteddug	621	13	belt	belt	NN
cord-306904-8iteddug	621	14	structure	structure	NN
cord-306904-8iteddug	621	15	233	233	CD
cord-306904-8iteddug	621	16	,	,	,
cord-306904-8iteddug	621	17	234	234	CD
cord-306904-8iteddug	621	18	and	and	CC
cord-306904-8iteddug	621	19	plays	play	VBZ
cord-306904-8iteddug	621	20	a	a	DT
cord-306904-8iteddug	621	21	major	major	JJ
cord-306904-8iteddug	621	22	role	role	NN
cord-306904-8iteddug	621	23	in	in	IN
cord-306904-8iteddug	621	24	the	the	DT
cord-306904-8iteddug	621	25	reverse	reverse	JJ
cord-306904-8iteddug	621	26	cholesterol	cholesterol	NN
cord-306904-8iteddug	621	27	transport	transport	NN
cord-306904-8iteddug	621	28	pathway	pathway	NN
cord-306904-8iteddug	621	29	.	.	.
cord-306904-8iteddug	622	1	235	235	CD
cord-306904-8iteddug	623	1	,	,	,
cord-306904-8iteddug	623	2	236	236	CD
cord-306904-8iteddug	623	3	ApoA	ApoA	NNP
cord-306904-8iteddug	623	4	-	-	HYPH
cord-306904-8iteddug	623	5	I	-PRON-	PRP
cord-306904-8iteddug	623	6	contains	contain	VBZ
cord-306904-8iteddug	623	7	a	a	DT
cord-306904-8iteddug	623	8	globular	globular	JJ
cord-306904-8iteddug	623	9	N	n	CD
cord-306904-8iteddug	623	10	-	-	HYPH
cord-306904-8iteddug	623	11	terminal	terminal	NN
cord-306904-8iteddug	623	12	domain	domain	NN
cord-306904-8iteddug	623	13	(	(	-LRB-
cord-306904-8iteddug	623	14	residues	residue	NNS
cord-306904-8iteddug	623	15	1	1	CD
cord-306904-8iteddug	623	16	-	-	SYM
cord-306904-8iteddug	623	17	43	43	CD
cord-306904-8iteddug	623	18	)	)	-RRB-
cord-306904-8iteddug	623	19	and	and	CC
cord-306904-8iteddug	623	20	a	a	DT
cord-306904-8iteddug	623	21	lipid	lipid	NN
cord-306904-8iteddug	623	22	-	-	HYPH
cord-306904-8iteddug	623	23	binding	bind	VBG
cord-306904-8iteddug	623	24	C	c	NN
cord-306904-8iteddug	623	25	-	-	HYPH
cord-306904-8iteddug	623	26	terminal	terminal	NN
cord-306904-8iteddug	623	27	domain	domain	NN
cord-306904-8iteddug	623	28	(	(	-LRB-
cord-306904-8iteddug	623	29	residues	residue	NNS
cord-306904-8iteddug	623	30	44	44	CD
cord-306904-8iteddug	623	31	-	-	SYM
cord-306904-8iteddug	623	32	243	243	CD
cord-306904-8iteddug	623	33	)	)	-RRB-
cord-306904-8iteddug	623	34	.	.	.
cord-306904-8iteddug	624	1	234	234	CD
cord-306904-8iteddug	625	1	In	in	IN
cord-306904-8iteddug	625	2	the	the	DT
cord-306904-8iteddug	625	3	belt	belt	NN
cord-306904-8iteddug	625	4	-	-	HYPH
cord-306904-8iteddug	625	5	like	like	JJ
cord-306904-8iteddug	625	6	structure	structure	NN
cord-306904-8iteddug	625	7	of	of	IN
cord-306904-8iteddug	625	8	the	the	DT
cord-306904-8iteddug	625	9	smallest	small	JJS
cord-306904-8iteddug	625	10	discoidal	discoidal	JJ
cord-306904-8iteddug	625	11	HDL	HDL	NNP
cord-306904-8iteddug	625	12	,	,	,
cord-306904-8iteddug	625	13	2	2	CD
cord-306904-8iteddug	625	14	apoA	apoa	NN
cord-306904-8iteddug	625	15	-	-	HYPH
cord-306904-8iteddug	625	16	I	-PRON-	PRP
cord-306904-8iteddug	625	17	molecules	molecule	NNS
cord-306904-8iteddug	625	18	wrap	wrap	VBP
cord-306904-8iteddug	625	19	around	around	RP
cord-306904-8iteddug	625	20	a	a	DT
cord-306904-8iteddug	625	21	small	small	JJ
cord-306904-8iteddug	625	22	patch	patch	NN
cord-306904-8iteddug	625	23	of	of	IN
cord-306904-8iteddug	625	24	bilayer	bilayer	NN
cord-306904-8iteddug	625	25	containing	contain	VBG
cord-306904-8iteddug	625	26	160	160	CD
cord-306904-8iteddug	625	27	lipid	lipid	NN
cord-306904-8iteddug	625	28	molecules	molecule	NNS
cord-306904-8iteddug	625	29	.	.	.
cord-306904-8iteddug	626	1	The	the	DT
cord-306904-8iteddug	626	2	C	c	NN
cord-306904-8iteddug	626	3	-	-	HYPH
cord-306904-8iteddug	626	4	terminal	terminal	NN
cord-306904-8iteddug	626	5	domain	domain	NN
cord-306904-8iteddug	626	6	of	of	IN
cord-306904-8iteddug	626	7	each	each	DT
cord-306904-8iteddug	626	8	monomer	monomer	NN
cord-306904-8iteddug	626	9	is	be	VBZ
cord-306904-8iteddug	626	10	ring	ring	NN
cord-306904-8iteddug	626	11	-	-	HYPH
cord-306904-8iteddug	626	12	like	like	JJ
cord-306904-8iteddug	626	13	,	,	,
cord-306904-8iteddug	626	14	curved	curved	JJ
cord-306904-8iteddug	626	15	,	,	,
cord-306904-8iteddug	626	16	planar	planar	JJ
cord-306904-8iteddug	626	17	amphipathic	amphipathic	FW
cord-306904-8iteddug	626	18	a	a	DT
cord-306904-8iteddug	626	19	-	-	HYPH
cord-306904-8iteddug	626	20	helix	helix	NN
cord-306904-8iteddug	626	21	with	with	IN
cord-306904-8iteddug	626	22	the	the	DT
cord-306904-8iteddug	626	23	hydrophobic	hydrophobic	JJ
cord-306904-8iteddug	626	24	surface	surface	NN
cord-306904-8iteddug	626	25	curved	curved	JJ
cord-306904-8iteddug	626	26	toward	toward	IN
cord-306904-8iteddug	626	27	the	the	DT
cord-306904-8iteddug	626	28	lipids	lipid	NNS
cord-306904-8iteddug	626	29	.	.	.
cord-306904-8iteddug	627	1	234	234	CD
cord-306904-8iteddug	627	2	Figure	figure	NN
cord-306904-8iteddug	627	3	21	21	CD
cord-306904-8iteddug	627	4	shows	show	NNS
cord-306904-8iteddug	627	5	that	that	IN
cord-306904-8iteddug	627	6	both	both	CC
cord-306904-8iteddug	627	7	human	human	JJ
cord-306904-8iteddug	627	8	and	and	CC
cord-306904-8iteddug	627	9	mouse	mouse	NN
cord-306904-8iteddug	627	10	ApoA	ApoA	NNP
cord-306904-8iteddug	627	11	-	-	HYPH
cord-306904-8iteddug	627	12	I	-PRON-	PRP
cord-306904-8iteddug	627	13	proteins	protein	NNS
cord-306904-8iteddug	627	14	(	(	-LRB-
cord-306904-8iteddug	627	15	UniProt	UniProt	NNP
cord-306904-8iteddug	627	16	IDs	id	NNS
cord-306904-8iteddug	627	17	:	:	:
cord-306904-8iteddug	627	18	P02647	p02647	JJ
cord-306904-8iteddug	627	19	and	and	CC
cord-306904-8iteddug	627	20	Q00623	Q00623	NNP
cord-306904-8iteddug	627	21	)	)	-RRB-
cord-306904-8iteddug	627	22	are	be	VBP
cord-306904-8iteddug	627	23	predicted	predict	VBN
cord-306904-8iteddug	627	24	to	to	TO
cord-306904-8iteddug	627	25	be	be	VB
cord-306904-8iteddug	627	26	mostly	mostly	RB
cord-306904-8iteddug	627	27	disordered	disordered	JJ
cord-306904-8iteddug	627	28	,	,	,
cord-306904-8iteddug	627	29	with	with	IN
cord-306904-8iteddug	627	30	mouse	mouse	NN
cord-306904-8iteddug	627	31	protein	protein	NN
cord-306904-8iteddug	627	32	possessing	possess	VBG
cord-306904-8iteddug	627	33	a	a	DT
cord-306904-8iteddug	627	34	bit	bit	NN
cord-306904-8iteddug	627	35	more	more	RBR
cord-306904-8iteddug	627	36	disordered	disordered	JJ
cord-306904-8iteddug	627	37	structure	structure	NN
cord-306904-8iteddug	627	38	.	.	.
cord-306904-8iteddug	628	1	According	accord	VBG
cord-306904-8iteddug	628	2	to	to	IN
cord-306904-8iteddug	628	3	the	the	DT
cord-306904-8iteddug	628	4	ANCHOR	anchor	NN
cord-306904-8iteddug	628	5	analysis	analysis	NN
cord-306904-8iteddug	628	6	,	,	,
cord-306904-8iteddug	628	7	there	there	EX
cord-306904-8iteddug	628	8	are	be	VBP
cord-306904-8iteddug	628	9	3	3	CD
cord-306904-8iteddug	628	10	AiBSs	AiBSs	JJS
cord-306904-8iteddug	628	11	in	in	IN
cord-306904-8iteddug	628	12	both	both	DT
cord-306904-8iteddug	628	13	proteins	protein	NNS
cord-306904-8iteddug	628	14	(	(	-LRB-
cord-306904-8iteddug	628	15	residues	residue	NNS
cord-306904-8iteddug	628	16	15	15	CD
cord-306904-8iteddug	628	17	-	-	SYM
cord-306904-8iteddug	628	18	21	21	CD
cord-306904-8iteddug	628	19	,	,	,
cord-306904-8iteddug	628	20	158	158	CD
cord-306904-8iteddug	628	21	-	-	SYM
cord-306904-8iteddug	628	22	164	164	CD
cord-306904-8iteddug	628	23	,	,	,
cord-306904-8iteddug	628	24	and	and	CC
cord-306904-8iteddug	628	25	221	221	CD
cord-306904-8iteddug	628	26	-	-	SYM
cord-306904-8iteddug	628	27	230	230	CD
cord-306904-8iteddug	628	28	in	in	IN
cord-306904-8iteddug	628	29	human	human	JJ
cord-306904-8iteddug	628	30	protein	protein	NN
cord-306904-8iteddug	628	31	,	,	,
cord-306904-8iteddug	628	32	and	and	CC
cord-306904-8iteddug	628	33	residues	residue	VBZ
cord-306904-8iteddug	628	34	13	13	CD
cord-306904-8iteddug	628	35	-	-	SYM
cord-306904-8iteddug	628	36	18	18	CD
cord-306904-8iteddug	628	37	,	,	,
cord-306904-8iteddug	628	38	173	173	CD
cord-306904-8iteddug	628	39	-	-	SYM
cord-306904-8iteddug	628	40	204	204	CD
cord-306904-8iteddug	628	41	,	,	,
cord-306904-8iteddug	628	42	and	and	CC
cord-306904-8iteddug	628	43	207	207	CD
cord-306904-8iteddug	628	44	-	-	SYM
cord-306904-8iteddug	628	45	230	230	CD
cord-306904-8iteddug	628	46	in	in	IN
cord-306904-8iteddug	628	47	mouse	mouse	NN
cord-306904-8iteddug	628	48	ApoA	ApoA	NNP
cord-306904-8iteddug	628	49	-	-	HYPH
cord-306904-8iteddug	628	50	I	I	NNP
cord-306904-8iteddug	628	51	)	)	-RRB-
cord-306904-8iteddug	628	52	.	.	.
cord-306904-8iteddug	629	1	Figure	figure	NN
cord-306904-8iteddug	629	2	21C	21c	CD
cord-306904-8iteddug	629	3	represents	represent	VBZ
cord-306904-8iteddug	629	4	a	a	DT
cord-306904-8iteddug	629	5	structure	structure	NN
cord-306904-8iteddug	629	6	of	of	IN
cord-306904-8iteddug	629	7	the	the	DT
cord-306904-8iteddug	629	8	human	human	JJ
cord-306904-8iteddug	629	9	ApoA	ApoA	NNP
cord-306904-8iteddug	629	10	-	-	HYPH
cord-306904-8iteddug	629	11	I	-PRON-	PRP
cord-306904-8iteddug	629	12	dimer	dimer	VBP
cord-306904-8iteddug	629	13	in	in	IN
cord-306904-8iteddug	629	14	a	a	DT
cord-306904-8iteddug	629	15	complex	complex	NN
cord-306904-8iteddug	629	16	with	with	IN
cord-306904-8iteddug	629	17	lipids	lipid	NNS
cord-306904-8iteddug	629	18	(	(	-LRB-
cord-306904-8iteddug	629	19	PDB	PDB	NNP
cord-306904-8iteddug	629	20	ID	ID	NNP
cord-306904-8iteddug	629	21	:	:	:
cord-306904-8iteddug	629	22	3K2S	3k2s	CD
cord-306904-8iteddug	629	23	)	)	-RRB-
cord-306904-8iteddug	629	24	.	.	.
cord-306904-8iteddug	630	1	This	this	DT
cord-306904-8iteddug	630	2	model	model	NN
cord-306904-8iteddug	630	3	was	be	VBD
cord-306904-8iteddug	630	4	built	build	VBN
cord-306904-8iteddug	630	5	by	by	IN
cord-306904-8iteddug	630	6	uniting	unite	VBG
cord-306904-8iteddug	630	7	several	several	JJ
cord-306904-8iteddug	630	8	synergistic	synergistic	JJ
cord-306904-8iteddug	630	9	experimental	experimental	JJ
cord-306904-8iteddug	630	10	techniques	technique	NNS
cord-306904-8iteddug	630	11	,	,	,
cord-306904-8iteddug	630	12	such	such	JJ
cord-306904-8iteddug	630	13	as	as	IN
cord-306904-8iteddug	630	14	small	small	JJ
cord-306904-8iteddug	630	15	angle	angle	NN
cord-306904-8iteddug	630	16	neutron	neutron	NN
cord-306904-8iteddug	630	17	scattering	scattering	NN
cord-306904-8iteddug	630	18	(	(	-LRB-
cord-306904-8iteddug	630	19	SANS	sans	NN
cord-306904-8iteddug	630	20	)	)	-RRB-
cord-306904-8iteddug	630	21	with	with	IN
cord-306904-8iteddug	630	22	contrast	contrast	NN
cord-306904-8iteddug	630	23	variation	variation	NN
cord-306904-8iteddug	630	24	,	,	,
cord-306904-8iteddug	630	25	isotopic	isotopic	JJ
cord-306904-8iteddug	630	26	deuteration	deuteration	NN
cord-306904-8iteddug	630	27	of	of	IN
cord-306904-8iteddug	630	28	selected	select	VBN
cord-306904-8iteddug	630	29	macromolecule	macromolecule	NN
cord-306904-8iteddug	630	30	components	component	NNS
cord-306904-8iteddug	630	31	,	,	,
cord-306904-8iteddug	630	32	and	and	CC
cord-306904-8iteddug	630	33	hydrogen/	hydrogen/	CD
cord-306904-8iteddug	630	34	deuterium	deuterium	NN
cord-306904-8iteddug	630	35	exchange	exchange	NN
cord-306904-8iteddug	630	36	tandem	tandem	NN
cord-306904-8iteddug	630	37	mass	mass	NN
cord-306904-8iteddug	630	38	spectrometry	spectrometry	NN
cord-306904-8iteddug	630	39	(	(	-LRB-
cord-306904-8iteddug	630	40	HD	HD	NNP
cord-306904-8iteddug	630	41	-	-	HYPH
cord-306904-8iteddug	630	42	MS	MS	NNP
cord-306904-8iteddug	630	43	/	/	SYM
cord-306904-8iteddug	630	44	MS	MS	NNP
cord-306904-8iteddug	630	45	)	)	-RRB-
cord-306904-8iteddug	630	46	.	.	.
cord-306904-8iteddug	631	1	237	237	CD
cord-306904-8iteddug	632	1	In	in	IN
cord-306904-8iteddug	632	2	agreement	agreement	NN
cord-306904-8iteddug	632	3	with	with	IN
cord-306904-8iteddug	632	4	the	the	DT
cord-306904-8iteddug	632	5	results	result	NNS
cord-306904-8iteddug	632	6	of	of	IN
cord-306904-8iteddug	632	7	disorder	disorder	NN
cord-306904-8iteddug	632	8	predictions	prediction	NNS
cord-306904-8iteddug	632	9	,	,	,
cord-306904-8iteddug	632	10	the	the	DT
cord-306904-8iteddug	632	11	ApoA	ApoA	NNP
cord-306904-8iteddug	632	12	-	-	HYPH
cord-306904-8iteddug	632	13	I	I	NNP
cord-306904-8iteddug	632	14	dimer	dimer	NN
cord-306904-8iteddug	632	15	represents	represent	VBZ
cord-306904-8iteddug	632	16	a	a	DT
cord-306904-8iteddug	632	17	highly	highly	RB
cord-306904-8iteddug	632	18	intertwined	intertwine	VBN
cord-306904-8iteddug	632	19	double	double	JJ
cord-306904-8iteddug	632	20	superhelix	superhelix	NN
cord-306904-8iteddug	632	21	with	with	IN
cord-306904-8iteddug	632	22	a	a	DT
cord-306904-8iteddug	632	23	minimal	minimal	JJ
cord-306904-8iteddug	632	24	number	number	NN
cord-306904-8iteddug	632	25	of	of	IN
cord-306904-8iteddug	632	26	intrachain	intrachain	NN
cord-306904-8iteddug	632	27	contacts	contact	NNS
cord-306904-8iteddug	632	28	,	,	,
cord-306904-8iteddug	632	29	which	which	WDT
cord-306904-8iteddug	632	30	is	be	VBZ
cord-306904-8iteddug	632	31	stabilized	stabilize	VBN
cord-306904-8iteddug	632	32	mostly	mostly	RB
cord-306904-8iteddug	632	33	by	by	IN
cord-306904-8iteddug	632	34	the	the	DT
cord-306904-8iteddug	632	35	interchain	interchain	JJ
cord-306904-8iteddug	632	36	interactions	interaction	NNS
cord-306904-8iteddug	632	37	.	.	.
cord-306904-8iteddug	633	1	In	in	IN
cord-306904-8iteddug	633	2	other	other	JJ
cord-306904-8iteddug	633	3	words	word	NNS
cord-306904-8iteddug	633	4	,	,	,
cord-306904-8iteddug	633	5	this	this	DT
cord-306904-8iteddug	633	6	complex	complex	NN
cord-306904-8iteddug	633	7	is	be	VBZ
cord-306904-8iteddug	633	8	characterized	characterize	VBN
cord-306904-8iteddug	633	9	by	by	IN
cord-306904-8iteddug	633	10	a	a	DT
cord-306904-8iteddug	633	11	very	very	RB
cord-306904-8iteddug	633	12	large	large	JJ
cord-306904-8iteddug	633	13	interface	interface	NN
cord-306904-8iteddug	633	14	area	area	NN
cord-306904-8iteddug	633	15	,	,	,
cord-306904-8iteddug	633	16	and	and	CC
cord-306904-8iteddug	633	17	,	,	,
cord-306904-8iteddug	633	18	therefore	therefore	RB
cord-306904-8iteddug	633	19	,	,	,
cord-306904-8iteddug	633	20	according	accord	VBG
cord-306904-8iteddug	633	21	to	to	IN
cord-306904-8iteddug	633	22	Gunasekaran	Gunasekaran	NNP
cord-306904-8iteddug	633	23	et	et	NNP
cord-306904-8iteddug	633	24	al	al	NNP
cord-306904-8iteddug	633	25	.	.	.
cord-306904-8iteddug	634	1	238	238	CD
cord-306904-8iteddug	635	1	it	-PRON-	PRP
cord-306904-8iteddug	635	2	belong	belong	VBP
cord-306904-8iteddug	635	3	to	to	IN
cord-306904-8iteddug	635	4	the	the	DT
cord-306904-8iteddug	635	5	category	category	NN
cord-306904-8iteddug	635	6	of	of	IN
cord-306904-8iteddug	635	7	2-state	2-state	CD
cord-306904-8iteddug	635	8	dimers	dimer	NNS
cord-306904-8iteddug	635	9	,	,	,
cord-306904-8iteddug	635	10	where	where	WRB
cord-306904-8iteddug	635	11	the	the	DT
cord-306904-8iteddug	635	12	monomers	monomer	NNS
cord-306904-8iteddug	635	13	are	be	VBP
cord-306904-8iteddug	635	14	unfolded	unfold	VBN
cord-306904-8iteddug	635	15	in	in	IN
cord-306904-8iteddug	635	16	the	the	DT
cord-306904-8iteddug	635	17	unbound	unbound	JJ
cord-306904-8iteddug	635	18	state	state	NN
cord-306904-8iteddug	635	19	and	and	CC
cord-306904-8iteddug	635	20	fold	fold	VB
cord-306904-8iteddug	635	21	simultaneously	simultaneously	RB
cord-306904-8iteddug	635	22	with	with	IN
cord-306904-8iteddug	635	23	the	the	DT
cord-306904-8iteddug	635	24	complex	complex	JJ
cord-306904-8iteddug	635	25	formation	formation	NN
cord-306904-8iteddug	635	26	.	.	.
cord-306904-8iteddug	636	1	Function	function	NN
cord-306904-8iteddug	636	2	and	and	CC
cord-306904-8iteddug	636	3	regulation	regulation	NN
cord-306904-8iteddug	636	4	of	of	IN
cord-306904-8iteddug	636	5	MAVS	MAVS	NNP
cord-306904-8iteddug	636	6	Jacobs	Jacobs	NNP
cord-306904-8iteddug	636	7	and	and	CC
cord-306904-8iteddug	636	8	Coyne	Coyne	NNP
cord-306904-8iteddug	636	9	provided	provide	VBD
cord-306904-8iteddug	636	10	an	an	DT
cord-306904-8iteddug	636	11	important	important	JJ
cord-306904-8iteddug	636	12	overview	overview	NN
cord-306904-8iteddug	636	13	of	of	IN
cord-306904-8iteddug	636	14	the	the	DT
cord-306904-8iteddug	636	15	mitochondrial	mitochondrial	JJ
cord-306904-8iteddug	636	16	antiviral	antiviral	JJ
cord-306904-8iteddug	636	17	signaling	signal	VBG
cord-306904-8iteddug	636	18	protein	protein	NN
cord-306904-8iteddug	636	19	(	(	-LRB-
cord-306904-8iteddug	636	20	MAVS	MAVS	NNPS
cord-306904-8iteddug	636	21	,	,	,
cord-306904-8iteddug	636	22	also	also	RB
cord-306904-8iteddug	636	23	known	know	VBN
cord-306904-8iteddug	636	24	as	as	IN
cord-306904-8iteddug	636	25	IPS-1	IPS-1	NNP
cord-306904-8iteddug	636	26	/	/	SYM
cord-306904-8iteddug	636	27	VISA	VISA	NNP
cord-306904-8iteddug	636	28	/	/	SYM
cord-306904-8iteddug	636	29	Cardif	Cardif	NNP
cord-306904-8iteddug	636	30	)	)	-RRB-
cord-306904-8iteddug	636	31	.	.	.
cord-306904-8iteddug	637	1	239	239	CD
cord-306904-8iteddug	637	2	MAVS	MAVS	NNPS
cord-306904-8iteddug	637	3	is	be	VBZ
cord-306904-8iteddug	637	4	the	the	DT
cord-306904-8iteddug	637	5	mitochondrially	mitochondrially	RB
cord-306904-8iteddug	637	6	-	-	HYPH
cord-306904-8iteddug	637	7	located	locate	VBN
cord-306904-8iteddug	637	8	innate	innate	JJ
cord-306904-8iteddug	637	9	immune	immune	JJ
cord-306904-8iteddug	637	10	signaling	signal	VBG
cord-306904-8iteddug	637	11	adaptor	adaptor	NN
cord-306904-8iteddug	637	12	regulating	regulating	NN
cord-306904-8iteddug	637	13	and	and	CC
cord-306904-8iteddug	637	14	coordinating	coordinating	NN
cord-306904-8iteddug	637	15	signals	signal	NNS
cord-306904-8iteddug	637	16	received	receive	VBN
cord-306904-8iteddug	637	17	from	from	IN
cord-306904-8iteddug	637	18	2	2	CD
cord-306904-8iteddug	637	19	independent	independent	JJ
cord-306904-8iteddug	637	20	cytosolic	cytosolic	JJ
cord-306904-8iteddug	637	21	pathogen	pathogen	NN
cord-306904-8iteddug	637	22	recognition	recognition	NN
cord-306904-8iteddug	637	23	receptors	receptor	NNS
cord-306904-8iteddug	637	24	to	to	TO
cord-306904-8iteddug	637	25	induce	induce	VB
cord-306904-8iteddug	637	26	antiviral	antiviral	JJ
cord-306904-8iteddug	637	27	genes	gene	NNS
cord-306904-8iteddug	637	28	.	.	.
cord-306904-8iteddug	638	1	MAVS	MAVS	NNP
cord-306904-8iteddug	638	2	can	can	MD
cord-306904-8iteddug	638	3	be	be	VB
cord-306904-8iteddug	638	4	regulated	regulate	VBN
cord-306904-8iteddug	638	5	by	by	IN
cord-306904-8iteddug	638	6	host	host	NN
cord-306904-8iteddug	638	7	cell	cell	NN
cord-306904-8iteddug	638	8	factors	factor	NNS
cord-306904-8iteddug	638	9	that	that	WDT
cord-306904-8iteddug	638	10	inhibit	inhibit	VBP
cord-306904-8iteddug	638	11	MAVS	MAVS	NNP
cord-306904-8iteddug	638	12	signaling	signal	VBG
cord-306904-8iteddug	638	13	by	by	IN
cord-306904-8iteddug	638	14	direct	direct	JJ
cord-306904-8iteddug	638	15	protein	protein	NN
cord-306904-8iteddug	638	16	-	-	HYPH
cord-306904-8iteddug	638	17	protein	protein	NN
cord-306904-8iteddug	638	18	interactions	interaction	NNS
cord-306904-8iteddug	638	19	,	,	,
cord-306904-8iteddug	638	20	by	by	IN
cord-306904-8iteddug	638	21	altering	alter	VBG
cord-306904-8iteddug	638	22	mitochondrial	mitochondrial	JJ
cord-306904-8iteddug	638	23	properties	property	NNS
cord-306904-8iteddug	638	24	or	or	CC
cord-306904-8iteddug	638	25	dynamics	dynamic	NNS
cord-306904-8iteddug	638	26	,	,	,
cord-306904-8iteddug	638	27	or	or	CC
cord-306904-8iteddug	638	28	by	by	IN
cord-306904-8iteddug	638	29	post	post	JJ
cord-306904-8iteddug	638	30	-	-	JJ
cord-306904-8iteddug	638	31	translational	translational	JJ
cord-306904-8iteddug	638	32	modifications	modification	NNS
cord-306904-8iteddug	638	33	.	.	.
cord-306904-8iteddug	639	1	239	239	CD
cord-306904-8iteddug	640	1	The	the	DT
cord-306904-8iteddug	640	2	tip	tip	NN
cord-306904-8iteddug	640	3	of	of	IN
cord-306904-8iteddug	640	4	the	the	DT
cord-306904-8iteddug	640	5	MAVS	MAVS	NNP
cord-306904-8iteddug	640	6	C	C	NNP
cord-306904-8iteddug	640	7	-	-	HYPH
cord-306904-8iteddug	640	8	terminus	terminus	NN
cord-306904-8iteddug	640	9	contains	contain	VBZ
cord-306904-8iteddug	640	10	a	a	DT
cord-306904-8iteddug	640	11	mitochondrial	mitochondrial	JJ
cord-306904-8iteddug	640	12	intermembrane	intermembrane	NN
cord-306904-8iteddug	640	13	region	region	NN
cord-306904-8iteddug	640	14	(	(	-LRB-
cord-306904-8iteddug	640	15	residues	residue	NNS
cord-306904-8iteddug	640	16	535	535	CD
cord-306904-8iteddug	640	17	-	-	SYM
cord-306904-8iteddug	640	18	540	540	CD
cord-306904-8iteddug	640	19	)	)	-RRB-
cord-306904-8iteddug	640	20	needed	need	VBD
cord-306904-8iteddug	640	21	for	for	IN
cord-306904-8iteddug	640	22	the	the	DT
cord-306904-8iteddug	640	23	interaction	interaction	NN
cord-306904-8iteddug	640	24	with	with	IN
cord-306904-8iteddug	640	25	the	the	DT
cord-306904-8iteddug	640	26	mitochondrial	mitochondrial	JJ
cord-306904-8iteddug	640	27	membrane	membrane	NN
cord-306904-8iteddug	640	28	.	.	.
cord-306904-8iteddug	641	1	According	accord	VBG
cord-306904-8iteddug	641	2	to	to	IN
cord-306904-8iteddug	641	3	UniProt	UniProt	NNP
cord-306904-8iteddug	641	4	,	,	,
cord-306904-8iteddug	641	5	human	human	JJ
cord-306904-8iteddug	641	6	MAVS	MAVS	NNPS
cord-306904-8iteddug	641	7	(	(	-LRB-
cord-306904-8iteddug	641	8	UniProt	UniProt	NNP
cord-306904-8iteddug	641	9	ID	ID	NNP
cord-306904-8iteddug	641	10	:	:	:
cord-306904-8iteddug	641	11	Q7Z434	Q7Z434	NNP
cord-306904-8iteddug	641	12	)	)	-RRB-
cord-306904-8iteddug	641	13	is	be	VBZ
cord-306904-8iteddug	641	14	involved	involve	VBN
cord-306904-8iteddug	641	15	in	in	IN
cord-306904-8iteddug	641	16	a	a	DT
cord-306904-8iteddug	641	17	wide	wide	JJ
cord-306904-8iteddug	641	18	array	array	NN
cord-306904-8iteddug	641	19	of	of	IN
cord-306904-8iteddug	641	20	protein	protein	NN
cord-306904-8iteddug	641	21	-	-	HYPH
cord-306904-8iteddug	641	22	protein	protein	NN
cord-306904-8iteddug	641	23	interactions	interaction	NNS
cord-306904-8iteddug	641	24	.	.	.
cord-306904-8iteddug	642	1	Among	among	IN
cord-306904-8iteddug	642	2	established	established	JJ
cord-306904-8iteddug	642	3	MAVS	MAVS	NNP
cord-306904-8iteddug	642	4	binding	bind	VBG
cord-306904-8iteddug	642	5	proteins	protein	NNS
cord-306904-8iteddug	642	6	are	be	VBP
cord-306904-8iteddug	642	7	:	:	:
cord-306904-8iteddug	643	1	DDX58	DDX58	NNP
cord-306904-8iteddug	643	2	/	/	SYM
cord-306904-8iteddug	643	3	RIG	rig	NN
cord-306904-8iteddug	644	1	-I	-I	NNP
cord-306904-8iteddug	644	2	,	,	,
cord-306904-8iteddug	644	3	IFIH1	IFIH1	NNP
cord-306904-8iteddug	644	4	/	/	SYM
cord-306904-8iteddug	644	5	MDA5	MDA5	NNP
cord-306904-8iteddug	644	6	,	,	,
cord-306904-8iteddug	644	7	 	 	_SP
cord-306904-8iteddug	644	8	TRAF2	TRAF2	NNP
cord-306904-8iteddug	644	9	,	,	,
cord-306904-8iteddug	644	10	TRAF6	TRAF6	NNP
cord-306904-8iteddug	644	11	,	,	,
cord-306904-8iteddug	644	12	C1QBP	C1QBP	NNP
cord-306904-8iteddug	644	13	,	,	,
cord-306904-8iteddug	644	14	IRF3	IRF3	NNP
cord-306904-8iteddug	644	15	,	,	,
cord-306904-8iteddug	644	16	FADD	FADD	NNP
cord-306904-8iteddug	644	17	,	,	,
cord-306904-8iteddug	644	18	 	 	_SP
cord-306904-8iteddug	644	19	RIPK1	RIPK1	NNP
cord-306904-8iteddug	644	20	,	,	,
cord-306904-8iteddug	644	21	CHUK	CHUK	NNPS
cord-306904-8iteddug	644	22	,	,	,
cord-306904-8iteddug	644	23	IKBKB	IKBKB	NNP
cord-306904-8iteddug	644	24	,	,	,
cord-306904-8iteddug	644	25	HCV	HCV	NNP
cord-306904-8iteddug	644	26	and	and	CC
cord-306904-8iteddug	644	27	hepatitis	hepatitis	NN
cord-306904-8iteddug	644	28	GB	GB	NNP
cord-306904-8iteddug	644	29	virus	virus	NN
cord-306904-8iteddug	644	30	B	b	NN
cord-306904-8iteddug	644	31	NS3/4A	ns3/4a	NN
cord-306904-8iteddug	644	32	proteases	protease	NNS
cord-306904-8iteddug	644	33	,	,	,
cord-306904-8iteddug	644	34	 	 	_SP
cord-306904-8iteddug	644	35	HHAV	HHAV	NNP
cord-306904-8iteddug	644	36	protein	protein	NN
cord-306904-8iteddug	645	1	3ABC	3abc	RB
cord-306904-8iteddug	645	2	,	,	,
cord-306904-8iteddug	646	1	NLRX1	NLRX1	NNP
cord-306904-8iteddug	646	2	,	,	,
cord-306904-8iteddug	646	3	PSMA7	PSMA7	NNP
cord-306904-8iteddug	646	4	,	,	,
cord-306904-8iteddug	646	5	 	 	_SP
cord-306904-8iteddug	647	1	TRAFD1	TRAFD1	NNP
cord-306904-8iteddug	647	2	,	,	,
cord-306904-8iteddug	648	1	PCBP2	PCBP2	NNP
cord-306904-8iteddug	648	2	,	,	,
cord-306904-8iteddug	648	3	IPS1	IPS1	NNP
cord-306904-8iteddug	648	4	,	,	,
cord-306904-8iteddug	648	5	ITCH	ITCH	NNP
cord-306904-8iteddug	648	6	,	,	,
cord-306904-8iteddug	648	7	CYLD	CYLD	NNP
cord-306904-8iteddug	648	8	,	,	,
cord-306904-8iteddug	648	9	 	 	_SP
cord-306904-8iteddug	648	10	SRC	SRC	NNP
cord-306904-8iteddug	648	11	,	,	,
cord-306904-8iteddug	649	1	DHX58	DHX58	NNP
cord-306904-8iteddug	649	2	/	/	SYM
cord-306904-8iteddug	649	3	LGP2	LGP2	NNP
cord-306904-8iteddug	649	4	,	,	,
cord-306904-8iteddug	649	5	DDX58	DDX58	NNP
cord-306904-8iteddug	649	6	/	/	SYM
cord-306904-8iteddug	649	7	RIG	rig	NN
cord-306904-8iteddug	649	8	-	-	:
cord-306904-8iteddug	649	9	I	I	NNP
cord-306904-8iteddug	649	10	,	,	,
cord-306904-8iteddug	649	11	 	 	_SP
cord-306904-8iteddug	649	12	IKBKE	IKBKE	NNP
cord-306904-8iteddug	649	13	,	,	,
cord-306904-8iteddug	649	14	TMEM173	TMEM173	NNP
cord-306904-8iteddug	649	15	/	/	SYM
cord-306904-8iteddug	649	16	MITA	MITA	NNP
cord-306904-8iteddug	649	17	,	,	,
cord-306904-8iteddug	649	18	IFIT3	ifit3	CC
cord-306904-8iteddug	649	19	,	,	,
cord-306904-8iteddug	649	20	 	 	_SP
cord-306904-8iteddug	649	21	TBK1	TBK1	NNP
cord-306904-8iteddug	649	22	,	,	,
cord-306904-8iteddug	649	23	and	and	CC
cord-306904-8iteddug	649	24	human	human	JJ
cord-306904-8iteddug	649	25	respiratory	respiratory	JJ
cord-306904-8iteddug	649	26	syncytial	syncytial	JJ
cord-306904-8iteddug	649	27	virus	virus	NN
cord-306904-8iteddug	649	28	(	(	-LRB-
cord-306904-8iteddug	649	29	HRSV	HRSV	NNP
cord-306904-8iteddug	649	30	)	)	-RRB-
cord-306904-8iteddug	649	31	NS1	ns1	NN
cord-306904-8iteddug	649	32	protein	protein	NN
cord-306904-8iteddug	649	33	(	(	-LRB-
cord-306904-8iteddug	649	34	http://www	http://www	NNP
cord-306904-8iteddug	649	35	.	.	.
cord-306904-8iteddug	649	36	uniprot.org/uniprot/Q7Z434	uniprot.org/uniprot/q7z434	LS
cord-306904-8iteddug	649	37	)	)	-RRB-
cord-306904-8iteddug	649	38	.	.	.
cord-306904-8iteddug	650	1	MAVS	MAVS	NNP
cord-306904-8iteddug	650	2	contains	contain	VBZ
cord-306904-8iteddug	650	3	multiple	multiple	JJ
cord-306904-8iteddug	650	4	alternatively	alternatively	RB
cord-306904-8iteddug	650	5	spliced	splice	VBN
cord-306904-8iteddug	650	6	isoforms	isoform	NNS
cord-306904-8iteddug	650	7	,	,	,
cord-306904-8iteddug	650	8	sites	site	NNS
cord-306904-8iteddug	650	9	of	of	IN
cord-306904-8iteddug	650	10	posttranslational	posttranslational	JJ
cord-306904-8iteddug	650	11	modifications	modification	NNS
cord-306904-8iteddug	650	12	,	,	,
cord-306904-8iteddug	650	13	and	and	CC
cord-306904-8iteddug	650	14	a	a	DT
cord-306904-8iteddug	650	15	proline	proline	JJ
cord-306904-8iteddug	650	16	-	-	HYPH
cord-306904-8iteddug	650	17	rich	rich	JJ
cord-306904-8iteddug	650	18	region	region	NN
cord-306904-8iteddug	650	19	(	(	-LRB-
cord-306904-8iteddug	650	20	residues	residue	NNS
cord-306904-8iteddug	650	21	.	.	.
cord-306904-8iteddug	651	1	In	in	IN
cord-306904-8iteddug	651	2	other	other	JJ
cord-306904-8iteddug	651	3	words	word	NNS
cord-306904-8iteddug	651	4	,	,	,
cord-306904-8iteddug	651	5	MAVS	MAVS	NNP
cord-306904-8iteddug	651	6	satisfies	satisfy	VBZ
cord-306904-8iteddug	651	7	all	all	PDT
cord-306904-8iteddug	651	8	the	the	DT
cord-306904-8iteddug	651	9	major	major	JJ
cord-306904-8iteddug	651	10	criteria	criterion	NNS
cord-306904-8iteddug	651	11	to	to	TO
cord-306904-8iteddug	651	12	be	be	VB
cord-306904-8iteddug	651	13	considered	consider	VBN
cord-306904-8iteddug	651	14	as	as	IN
cord-306904-8iteddug	651	15	an	an	DT
cord-306904-8iteddug	651	16	intrinsically	intrinsically	RB
cord-306904-8iteddug	651	17	disordered	disordered	JJ
cord-306904-8iteddug	651	18	protein	protein	NN
cord-306904-8iteddug	651	19	.	.	.
cord-306904-8iteddug	652	1	Figure	figure	NN
cord-306904-8iteddug	652	2	22A	22a	NN
cord-306904-8iteddug	652	3	represents	represent	VBZ
cord-306904-8iteddug	652	4	the	the	DT
cord-306904-8iteddug	652	5	vast	vast	JJ
cord-306904-8iteddug	652	6	interactome	interactome	NN
cord-306904-8iteddug	652	7	of	of	IN
cord-306904-8iteddug	652	8	MAVS	MAVS	NNPS
cord-306904-8iteddug	652	9	evaluated	evaluate	VBN
cord-306904-8iteddug	652	10	by	by	IN
cord-306904-8iteddug	652	11	STRING	string	NN
cord-306904-8iteddug	652	12	.	.	.
cord-306904-8iteddug	653	1	Figure	figure	NN
cord-306904-8iteddug	653	2	22B	22b	CD
cord-306904-8iteddug	653	3	shows	show	VBZ
cord-306904-8iteddug	653	4	that	that	IN
cord-306904-8iteddug	653	5	human	human	NN
cord-306904-8iteddug	653	6	MAVS	MAVS	NNPS
cord-306904-8iteddug	653	7	is	be	VBZ
cord-306904-8iteddug	653	8	predicted	predict	VBN
cord-306904-8iteddug	653	9	to	to	TO
cord-306904-8iteddug	653	10	be	be	VB
cord-306904-8iteddug	653	11	a	a	DT
cord-306904-8iteddug	653	12	highly	highly	RB
cord-306904-8iteddug	653	13	disordered	disordered	JJ
cord-306904-8iteddug	653	14	protein	protein	NN
cord-306904-8iteddug	653	15	.	.	.
cord-306904-8iteddug	654	1	ANCHOR	anchor	NN
cord-306904-8iteddug	654	2	analysis	analysis	NN
cord-306904-8iteddug	654	3	15	15	CD
cord-306904-8iteddug	654	4	 	 	_SP
cord-306904-8iteddug	655	1	Khasnis	Khasnis	NNP
cord-306904-8iteddug	655	2	et	et	NNP
cord-306904-8iteddug	655	3	al	al	NNP
cord-306904-8iteddug	655	4	.	.	.
cord-306904-8iteddug	655	5	analyzed	analyze	VBD
cord-306904-8iteddug	655	6	the	the	DT
cord-306904-8iteddug	655	7	mechanisms	mechanism	NNS
cord-306904-8iteddug	655	8	and	and	CC
cord-306904-8iteddug	655	9	functional	functional	JJ
cord-306904-8iteddug	655	10	outputs	output	NNS
cord-306904-8iteddug	655	11	of	of	IN
cord-306904-8iteddug	655	12	the	the	DT
cord-306904-8iteddug	655	13	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	655	14	/	/	SYM
cord-306904-8iteddug	655	15	dephosphorylation	dephosphorylation	NN
cord-306904-8iteddug	655	16	events	event	NNS
cord-306904-8iteddug	655	17	at	at	IN
cord-306904-8iteddug	655	18	Thr696	thr696	CD
cord-306904-8iteddug	655	19	and	and	CC
cord-306904-8iteddug	655	20	Thr853	thr853	DT
cord-306904-8iteddug	655	21	sites	site	NNS
cord-306904-8iteddug	655	22	of	of	IN
cord-306904-8iteddug	655	23	the	the	DT
cord-306904-8iteddug	655	24	MYPT1	MYPT1	NNP
cord-306904-8iteddug	655	25	protein	protein	NN
cord-306904-8iteddug	655	26	,	,	,
cord-306904-8iteddug	655	27	which	which	WDT
cord-306904-8iteddug	655	28	is	be	VBZ
cord-306904-8iteddug	655	29	a	a	DT
cord-306904-8iteddug	655	30	regulatory	regulatory	JJ
cord-306904-8iteddug	655	31	subunit	subunit	NN
cord-306904-8iteddug	655	32	of	of	IN
cord-306904-8iteddug	655	33	the	the	DT
cord-306904-8iteddug	655	34	myosin	myosin	NN
cord-306904-8iteddug	655	35	light	light	NN
cord-306904-8iteddug	655	36	chain	chain	NN
cord-306904-8iteddug	655	37	phosphatase	phosphatase	NN
cord-306904-8iteddug	655	38	(	(	-LRB-
cord-306904-8iteddug	655	39	MLCP	MLCP	NNP
cord-306904-8iteddug	655	40	)	)	-RRB-
cord-306904-8iteddug	655	41	.	.	.
cord-306904-8iteddug	656	1	240	240	CD
cord-306904-8iteddug	656	2	MLCP	MLCP	NNP
cord-306904-8iteddug	656	3	is	be	VBZ
cord-306904-8iteddug	656	4	a	a	DT
cord-306904-8iteddug	656	5	cytoskeleton	cytoskeleton	NN
cord-306904-8iteddug	656	6	-	-	HYPH
cord-306904-8iteddug	656	7	associated	associate	VBN
cord-306904-8iteddug	656	8	protein	protein	NN
cord-306904-8iteddug	656	9	phosphatase-1	phosphatase-1	NNP
cord-306904-8iteddug	656	10	(	(	-LRB-
cord-306904-8iteddug	656	11	PP1	PP1	NNP
cord-306904-8iteddug	656	12	)	)	-RRB-
cord-306904-8iteddug	656	13	that	that	WDT
cord-306904-8iteddug	656	14	serves	serve	VBZ
cord-306904-8iteddug	656	15	as	as	IN
cord-306904-8iteddug	656	16	a	a	DT
cord-306904-8iteddug	656	17	RhoA	RhoA	NNP
cord-306904-8iteddug	656	18	/	/	SYM
cord-306904-8iteddug	656	19	ROCK	ROCK	NNP
cord-306904-8iteddug	656	20	effector	effector	NN
cord-306904-8iteddug	656	21	,	,	,
cord-306904-8iteddug	656	22	regulating	regulate	VBG
cord-306904-8iteddug	656	23	dynamic	dynamic	JJ
cord-306904-8iteddug	656	24	reorganization	reorganization	NN
cord-306904-8iteddug	656	25	of	of	IN
cord-306904-8iteddug	656	26	the	the	DT
cord-306904-8iteddug	656	27	cytoskeleton	cytoskeleton	NN
cord-306904-8iteddug	656	28	crucial	crucial	JJ
cord-306904-8iteddug	656	29	for	for	IN
cord-306904-8iteddug	656	30	cell	cell	NN
cord-306904-8iteddug	656	31	motility	motility	NN
cord-306904-8iteddug	656	32	.	.	.
cord-306904-8iteddug	657	1	The	the	DT
cord-306904-8iteddug	657	2	authors	author	NNS
cord-306904-8iteddug	657	3	also	also	RB
cord-306904-8iteddug	657	4	showed	show	VBD
cord-306904-8iteddug	657	5	that	that	IN
cord-306904-8iteddug	657	6	the	the	DT
cord-306904-8iteddug	657	7	C	C	NNP
cord-306904-8iteddug	657	8	-	-	HYPH
cord-306904-8iteddug	657	9	terminal	terminal	NN
cord-306904-8iteddug	657	10	domain	domain	NN
cord-306904-8iteddug	657	11	of	of	IN
cord-306904-8iteddug	657	12	human	human	JJ
cord-306904-8iteddug	657	13	MYPT1	MYPT1	NNS
cord-306904-8iteddug	657	14	(	(	-LRB-
cord-306904-8iteddug	657	15	residues	residue	NNS
cord-306904-8iteddug	657	16	495	495	CD
cord-306904-8iteddug	657	17	-	-	HYPH
cord-306904-8iteddug	657	18	1030	1030	CD
cord-306904-8iteddug	657	19	)	)	-RRB-
cord-306904-8iteddug	657	20	was	be	VBD
cord-306904-8iteddug	657	21	responsible	responsible	JJ
cord-306904-8iteddug	657	22	for	for	IN
cord-306904-8iteddug	657	23	the	the	DT
cord-306904-8iteddug	657	24	binding	binding	NN
cord-306904-8iteddug	657	25	to	to	IN
cord-306904-8iteddug	657	26	the	the	DT
cord-306904-8iteddug	657	27	N	n	CD
cord-306904-8iteddug	657	28	-	-	HYPH
cord-306904-8iteddug	657	29	terminal	terminal	JJ
cord-306904-8iteddug	657	30	portion	portion	NN
cord-306904-8iteddug	657	31	of	of	IN
cord-306904-8iteddug	657	32	myosin	myosin	NN
cord-306904-8iteddug	657	33	light	light	JJ
cord-306904-8iteddug	657	34	meromyosin	meromyosin	NNP
cord-306904-8iteddug	657	35	.	.	.
cord-306904-8iteddug	658	1	240	240	CD
cord-306904-8iteddug	658	2	Promiscuous	promiscuous	JJ
cord-306904-8iteddug	658	3	interactability	interactability	NN
cord-306904-8iteddug	658	4	of	of	IN
cord-306904-8iteddug	658	5	MYPT1	MYPT1	NNP
cord-306904-8iteddug	658	6	is	be	VBZ
cord-306904-8iteddug	658	7	illustrated	illustrate	VBN
cord-306904-8iteddug	658	8	by	by	IN
cord-306904-8iteddug	658	9	Figure	figure	NN
cord-306904-8iteddug	658	10	23A	23a	NN
cord-306904-8iteddug	658	11	representing	represent	VBG
cord-306904-8iteddug	658	12	the	the	DT
cord-306904-8iteddug	658	13	results	result	NNS
cord-306904-8iteddug	658	14	of	of	IN
cord-306904-8iteddug	658	15	STRING	string	NN
cord-306904-8iteddug	658	16	analysis	analysis	NN
cord-306904-8iteddug	658	17	.	.	.
cord-306904-8iteddug	659	1	Figure	figure	NN
cord-306904-8iteddug	659	2	23B	23b	NN
cord-306904-8iteddug	659	3	shows	show	VBZ
cord-306904-8iteddug	659	4	that	that	IN
cord-306904-8iteddug	659	5	the	the	DT
cord-306904-8iteddug	659	6	very	very	RB
cord-306904-8iteddug	659	7	significant	significant	JJ
cord-306904-8iteddug	659	8	part	part	NN
cord-306904-8iteddug	659	9	of	of	IN
cord-306904-8iteddug	659	10	MYPT1	MYPT1	NNP
cord-306904-8iteddug	660	1	(	(	-LRB-
cord-306904-8iteddug	660	2	UniProt	UniProt	NNP
cord-306904-8iteddug	660	3	ID	ID	NNP
cord-306904-8iteddug	660	4	:	:	:
cord-306904-8iteddug	660	5	O14974	O14974	NNP
cord-306904-8iteddug	660	6	)	)	-RRB-
cord-306904-8iteddug	660	7	is	be	VBZ
cord-306904-8iteddug	660	8	expected	expect	VBN
cord-306904-8iteddug	660	9	to	to	TO
cord-306904-8iteddug	660	10	be	be	VB
cord-306904-8iteddug	660	11	intrinsically	intrinsically	RB
cord-306904-8iteddug	660	12	disordered	disordered	JJ
cord-306904-8iteddug	660	13	,	,	,
cord-306904-8iteddug	660	14	with	with	IN
cord-306904-8iteddug	660	15	longest	long	JJS
cord-306904-8iteddug	660	16	disordered	disordered	JJ
cord-306904-8iteddug	660	17	region	region	NN
cord-306904-8iteddug	660	18	covering	cover	VBG
cord-306904-8iteddug	660	19	»	»	$
cord-306904-8iteddug	660	20	72	72	CD
cord-306904-8iteddug	660	21	%	%	NN
cord-306904-8iteddug	660	22	of	of	IN
cord-306904-8iteddug	660	23	protein	protein	NN
cord-306904-8iteddug	660	24	length	length	NN
cord-306904-8iteddug	660	25	(	(	-LRB-
cord-306904-8iteddug	660	26	residues	residue	NNS
cord-306904-8iteddug	660	27	290	290	CD
cord-306904-8iteddug	660	28	-	-	HYPH
cord-306904-8iteddug	660	29	1030	1030	CD
cord-306904-8iteddug	660	30	)	)	-RRB-
cord-306904-8iteddug	660	31	and	and	CC
cord-306904-8iteddug	660	32	containing	contain	VBG
cord-306904-8iteddug	660	33	18	18	CD
cord-306904-8iteddug	660	34	disorder	disorder	NN
cord-306904-8iteddug	660	35	-	-	HYPH
cord-306904-8iteddug	660	36	based	base	VBN
cord-306904-8iteddug	660	37	binding	binding	NN
cord-306904-8iteddug	660	38	sites	site	NNS
cord-306904-8iteddug	660	39	(	(	-LRB-
cord-306904-8iteddug	660	40	residues	residue	NNS
cord-306904-8iteddug	660	41	 	 	_SP
cord-306904-8iteddug	660	42	318	318	CD
cord-306904-8iteddug	660	43	-	-	SYM
cord-306904-8iteddug	660	44	338	338	CD
cord-306904-8iteddug	660	45	,	,	,
cord-306904-8iteddug	660	46	374	374	CD
cord-306904-8iteddug	660	47	-	-	SYM
cord-306904-8iteddug	660	48	403	403	CD
cord-306904-8iteddug	660	49	,	,	,
cord-306904-8iteddug	660	50	406	406	CD
cord-306904-8iteddug	660	51	-	-	SYM
cord-306904-8iteddug	660	52	419	419	CD
cord-306904-8iteddug	660	53	,	,	,
cord-306904-8iteddug	660	54	434	434	CD
cord-306904-8iteddug	660	55	-	-	SYM
cord-306904-8iteddug	660	56	454	454	CD
cord-306904-8iteddug	660	57	,	,	,
cord-306904-8iteddug	660	58	 	 	_SP
cord-306904-8iteddug	660	59	472	472	CD
cord-306904-8iteddug	660	60	-	-	SYM
cord-306904-8iteddug	660	61	477	477	CD
cord-306904-8iteddug	660	62	,	,	,
cord-306904-8iteddug	660	63	 	 	_SP
cord-306904-8iteddug	660	64	492	492	CD
cord-306904-8iteddug	660	65	-	-	SYM
cord-306904-8iteddug	660	66	506	506	CD
cord-306904-8iteddug	660	67	,	,	,
cord-306904-8iteddug	660	68	548	548	CD
cord-306904-8iteddug	660	69	-	-	SYM
cord-306904-8iteddug	660	70	564	564	CD
cord-306904-8iteddug	660	71	,	,	,
cord-306904-8iteddug	660	72	579	579	CD
cord-306904-8iteddug	660	73	-	-	SYM
cord-306904-8iteddug	660	74	588	588	CD
cord-306904-8iteddug	660	75	,	,	,
cord-306904-8iteddug	660	76	626	626	CD
cord-306904-8iteddug	660	77	-	-	SYM
cord-306904-8iteddug	660	78	649	649	CD
cord-306904-8iteddug	660	79	,	,	,
cord-306904-8iteddug	660	80	 	 	_SP
cord-306904-8iteddug	660	81	666	666	CD
cord-306904-8iteddug	660	82	-	-	HYPH
cord-306904-8iteddug	660	83	673	673	CD
cord-306904-8iteddug	660	84	,	,	,
cord-306904-8iteddug	660	85	697	697	CD
cord-306904-8iteddug	660	86	-	-	SYM
cord-306904-8iteddug	660	87	712	712	CD
cord-306904-8iteddug	660	88	,	,	,
cord-306904-8iteddug	660	89	754	754	CD
cord-306904-8iteddug	660	90	-	-	SYM
cord-306904-8iteddug	660	91	774	774	CD
cord-306904-8iteddug	660	92	,	,	,
cord-306904-8iteddug	660	93	780	780	CD
cord-306904-8iteddug	660	94	-	-	HYPH
cord-306904-8iteddug	660	95	815	815	CD
cord-306904-8iteddug	660	96	,	,	,
cord-306904-8iteddug	660	97	 	 	_SP
cord-306904-8iteddug	660	98	853	853	CD
cord-306904-8iteddug	660	99	-	-	HYPH
cord-306904-8iteddug	660	100	860	860	CD
cord-306904-8iteddug	660	101	,	,	,
cord-306904-8iteddug	660	102	887	887	CD
cord-306904-8iteddug	660	103	-	-	SYM
cord-306904-8iteddug	660	104	892	892	CD
cord-306904-8iteddug	660	105	,	,	,
cord-306904-8iteddug	660	106	897	897	CD
cord-306904-8iteddug	660	107	-	-	HYPH
cord-306904-8iteddug	660	108	917	917	CD
cord-306904-8iteddug	660	109	-	-	HYPH
cord-306904-8iteddug	660	110	932	932	CD
cord-306904-8iteddug	660	111	-	-	HYPH
cord-306904-8iteddug	660	112	943	943	CD
cord-306904-8iteddug	660	113	,	,	,
cord-306904-8iteddug	660	114	 	 	_SP
cord-306904-8iteddug	660	115	and	and	CC
cord-306904-8iteddug	660	116	1021	1021	CD
cord-306904-8iteddug	660	117	-	-	SYM
cord-306904-8iteddug	660	118	1030	1030	CD
cord-306904-8iteddug	660	119	)	)	-RRB-
cord-306904-8iteddug	660	120	.	.	.
cord-306904-8iteddug	661	1	Clearly	clearly	RB
cord-306904-8iteddug	661	2	,	,	,
cord-306904-8iteddug	661	3	intrinsic	intrinsic	JJ
cord-306904-8iteddug	661	4	disorder	disorder	NN
cord-306904-8iteddug	661	5	is	be	VBZ
cord-306904-8iteddug	661	6	crucial	crucial	JJ
cord-306904-8iteddug	661	7	for	for	IN
cord-306904-8iteddug	661	8	function	function	NN
cord-306904-8iteddug	661	9	of	of	IN
cord-306904-8iteddug	661	10	this	this	DT
cord-306904-8iteddug	661	11	protein	protein	NN
cord-306904-8iteddug	661	12	.	.	.
cord-306904-8iteddug	662	1	Li	Li	NNP
cord-306904-8iteddug	662	2	et	et	NNP
cord-306904-8iteddug	662	3	al	al	NNP
cord-306904-8iteddug	662	4	.	.	.
cord-306904-8iteddug	663	1	investigated	investigate	VBN
cord-306904-8iteddug	663	2	structural	structural	JJ
cord-306904-8iteddug	663	3	peculiarities	peculiarity	NNS
cord-306904-8iteddug	663	4	of	of	IN
cord-306904-8iteddug	663	5	the	the	DT
cord-306904-8iteddug	663	6	core	core	NN
cord-306904-8iteddug	663	7	polypeptide	polypeptide	NN
cord-306904-8iteddug	663	8	of	of	IN
cord-306904-8iteddug	663	9	the	the	DT
cord-306904-8iteddug	663	10	inner	inner	JJ
cord-306904-8iteddug	663	11	membrane	membrane	NN
cord-306904-8iteddug	663	12	GerD	GerD	NNP
cord-306904-8iteddug	663	13	lipoprotein	lipoprotein	NN
cord-306904-8iteddug	663	14	from	from	IN
cord-306904-8iteddug	663	15	Geobacillus	Geobacillus	NNP
cord-306904-8iteddug	663	16	stearothermophilus	stearothermophilus	NN
cord-306904-8iteddug	663	17	.	.	.
cord-306904-8iteddug	664	1	241	241	CD
cord-306904-8iteddug	665	1	Some	some	DT
cord-306904-8iteddug	665	2	bacteria	bacteria	NNS
cord-306904-8iteddug	665	3	are	be	VBP
cord-306904-8iteddug	665	4	able	able	JJ
cord-306904-8iteddug	665	5	to	to	TO
cord-306904-8iteddug	665	6	form	form	VB
cord-306904-8iteddug	665	7	endospores	endospore	NNS
cord-306904-8iteddug	665	8	in	in	IN
cord-306904-8iteddug	665	9	response	response	NN
cord-306904-8iteddug	665	10	to	to	IN
cord-306904-8iteddug	665	11	adverse	adverse	JJ
cord-306904-8iteddug	665	12	growth	growth	NN
cord-306904-8iteddug	665	13	conditions	condition	NNS
cord-306904-8iteddug	665	14	.	.	.
cord-306904-8iteddug	666	1	242	242	CD
cord-306904-8iteddug	666	2	,	,	,
cord-306904-8iteddug	666	3	243	243	CD
cord-306904-8iteddug	666	4	Spores	spore	NNS
cord-306904-8iteddug	666	5	formed	form	VBN
cord-306904-8iteddug	666	6	as	as	IN
cord-306904-8iteddug	666	7	a	a	DT
cord-306904-8iteddug	666	8	result	result	NN
cord-306904-8iteddug	666	9	of	of	IN
cord-306904-8iteddug	666	10	such	such	JJ
cord-306904-8iteddug	666	11	sporulation	sporulation	NN
cord-306904-8iteddug	666	12	process	process	NN
cord-306904-8iteddug	666	13	are	be	VBP
cord-306904-8iteddug	666	14	extremely	extremely	RB
cord-306904-8iteddug	666	15	resistant	resistant	JJ
cord-306904-8iteddug	666	16	to	to	IN
cord-306904-8iteddug	666	17	various	various	JJ
cord-306904-8iteddug	666	18	environmental	environmental	JJ
cord-306904-8iteddug	666	19	insults	insult	NNS
cord-306904-8iteddug	666	20	thereby	thereby	RB
cord-306904-8iteddug	666	21	providing	provide	VBG
cord-306904-8iteddug	666	22	the	the	DT
cord-306904-8iteddug	666	23	bacteria	bacteria	NNS
cord-306904-8iteddug	666	24	with	with	IN
cord-306904-8iteddug	666	25	an	an	DT
cord-306904-8iteddug	666	26	important	important	JJ
cord-306904-8iteddug	666	27	means	mean	NNS
cord-306904-8iteddug	666	28	to	to	TO
cord-306904-8iteddug	666	29	exist	exist	VB
cord-306904-8iteddug	666	30	in	in	IN
cord-306904-8iteddug	666	31	the	the	DT
cord-306904-8iteddug	666	32	metabolically	metabolically	RB
cord-306904-8iteddug	666	33	dormant	dormant	JJ
cord-306904-8iteddug	666	34	state	state	NN
cord-306904-8iteddug	666	35	indefinitely	indefinitely	RB
cord-306904-8iteddug	666	36	and	and	CC
cord-306904-8iteddug	666	37	remain	remain	VBP
cord-306904-8iteddug	666	38	viable	viable	JJ
cord-306904-8iteddug	666	39	for	for	IN
cord-306904-8iteddug	666	40	hundreds	hundred	NNS
cord-306904-8iteddug	666	41	of	of	IN
cord-306904-8iteddug	666	42	years	year	NNS
cord-306904-8iteddug	666	43	without	without	IN
cord-306904-8iteddug	666	44	water	water	NN
cord-306904-8iteddug	666	45	or	or	CC
cord-306904-8iteddug	666	46	nutrients	nutrient	NNS
cord-306904-8iteddug	666	47	.	.	.
cord-306904-8iteddug	667	1	244	244	CD
cord-306904-8iteddug	667	2	,	,	,
cord-306904-8iteddug	667	3	245	245	CD
cord-306904-8iteddug	667	4	Restoration	restoration	NN
cord-306904-8iteddug	667	5	of	of	IN
cord-306904-8iteddug	667	6	the	the	DT
cord-306904-8iteddug	667	7	favorable	favorable	JJ
cord-306904-8iteddug	667	8	conditions	condition	NNS
cord-306904-8iteddug	667	9	triggers	trigger	VBZ
cord-306904-8iteddug	667	10	spore	spore	VBP
cord-306904-8iteddug	667	11	germination	germination	NN
cord-306904-8iteddug	667	12	leading	lead	VBG
cord-306904-8iteddug	667	13	to	to	IN
cord-306904-8iteddug	667	14	the	the	DT
cord-306904-8iteddug	667	15	fast	fast	JJ
cord-306904-8iteddug	667	16	(	(	-LRB-
cord-306904-8iteddug	667	17	within	within	IN
cord-306904-8iteddug	667	18	minutes	minute	NNS
cord-306904-8iteddug	667	19	)	)	-RRB-
cord-306904-8iteddug	667	20	"	"	``
cord-306904-8iteddug	667	21	awakening	awakening	NN
cord-306904-8iteddug	667	22	"	"	''
cord-306904-8iteddug	667	23	of	of	IN
cord-306904-8iteddug	667	24	the	the	DT
cord-306904-8iteddug	667	25	normal	normal	JJ
cord-306904-8iteddug	667	26	metabolism	metabolism	NN
cord-306904-8iteddug	667	27	in	in	IN
cord-306904-8iteddug	667	28	bacteria	bacteria	NNS
cord-306904-8iteddug	667	29	followed	follow	VBN
cord-306904-8iteddug	667	30	by	by	IN
cord-306904-8iteddug	667	31	outgrowth	outgrowth	NN
cord-306904-8iteddug	667	32	to	to	TO
cord-306904-8iteddug	667	33	generate	generate	VB
cord-306904-8iteddug	667	34	growing	grow	VBG
cord-306904-8iteddug	667	35	cells	cell	NNS
cord-306904-8iteddug	667	36	.	.	.
cord-306904-8iteddug	668	1	243	243	CD
cord-306904-8iteddug	668	2	,	,	,
cord-306904-8iteddug	668	3	244	244	CD
cord-306904-8iteddug	668	4	,	,	,
cord-306904-8iteddug	668	5	246	246	CD
cord-306904-8iteddug	669	1	This	this	DT
cord-306904-8iteddug	669	2	awakening	awakening	NN
cord-306904-8iteddug	669	3	is	be	VBZ
cord-306904-8iteddug	669	4	controlled	control	VBN
cord-306904-8iteddug	669	5	by	by	IN
cord-306904-8iteddug	669	6	the	the	DT
cord-306904-8iteddug	669	7	specific	specific	JJ
cord-306904-8iteddug	669	8	nutrient	nutrient	NN
cord-306904-8iteddug	669	9	sensors	sensor	NNS
cord-306904-8iteddug	669	10	,	,	,
cord-306904-8iteddug	669	11	cognate	cognate	JJ
cord-306904-8iteddug	669	12	germinant	germinant	JJ
cord-306904-8iteddug	669	13	receptors	receptor	NNS
cord-306904-8iteddug	669	14	(	(	-LRB-
cord-306904-8iteddug	669	15	GRs	GRs	NNP
cord-306904-8iteddug	669	16	)	)	-RRB-
cord-306904-8iteddug	669	17	located	locate	VBN
cord-306904-8iteddug	669	18	in	in	IN
cord-306904-8iteddug	669	19	the	the	DT
cord-306904-8iteddug	669	20	inner	inner	JJ
cord-306904-8iteddug	669	21	membrane	membrane	NN
cord-306904-8iteddug	669	22	of	of	IN
cord-306904-8iteddug	669	23	the	the	DT
cord-306904-8iteddug	669	24	spore	spore	NN
cord-306904-8iteddug	669	25	.	.	.
cord-306904-8iteddug	670	1	GerD	GerD	NNP
cord-306904-8iteddug	670	2	is	be	VBZ
cord-306904-8iteddug	670	3	one	one	CD
cord-306904-8iteddug	670	4	of	of	IN
cord-306904-8iteddug	670	5	such	such	JJ
cord-306904-8iteddug	670	6	bacterial	bacterial	JJ
cord-306904-8iteddug	670	7	cognate	cognate	JJ
cord-306904-8iteddug	670	8	germinant	germinant	JJ
cord-306904-8iteddug	670	9	receptors	receptor	NNS
cord-306904-8iteddug	670	10	that	that	WDT
cord-306904-8iteddug	670	11	trigger	trigger	VBP
cord-306904-8iteddug	670	12	spore	spore	NN
cord-306904-8iteddug	670	13	germination	germination	NN
cord-306904-8iteddug	670	14	in	in	IN
cord-306904-8iteddug	670	15	the	the	DT
cord-306904-8iteddug	670	16	presence	presence	NN
cord-306904-8iteddug	670	17	of	of	IN
cord-306904-8iteddug	670	18	specific	specific	JJ
cord-306904-8iteddug	670	19	nutrients	nutrient	NNS
cord-306904-8iteddug	670	20	called	call	VBN
cord-306904-8iteddug	670	21	germinants	germinant	NNS
cord-306904-8iteddug	670	22	in	in	IN
cord-306904-8iteddug	670	23	the	the	DT
cord-306904-8iteddug	670	24	environments	environment	NNS
cord-306904-8iteddug	670	25	of	of	IN
cord-306904-8iteddug	670	26	the	the	DT
cord-306904-8iteddug	670	27	spores	spore	NNS
cord-306904-8iteddug	670	28	.	.	.
cord-306904-8iteddug	671	1	241	241	CD
cord-306904-8iteddug	671	2	Li	Li	NNP
cord-306904-8iteddug	671	3	et	et	NNP
cord-306904-8iteddug	671	4	al	al	NNP
cord-306904-8iteddug	671	5	.	.	NNP
cord-306904-8iteddug	671	6	have	have	VBP
cord-306904-8iteddug	671	7	determined	determine	VBN
cord-306904-8iteddug	671	8	the	the	DT
cord-306904-8iteddug	671	9	crystal	crystal	JJ
cord-306904-8iteddug	671	10	structure	structure	NN
cord-306904-8iteddug	671	11	of	of	IN
cord-306904-8iteddug	671	12	the	the	DT
cord-306904-8iteddug	671	13	121-residue	121-residue	CD
cord-306904-8iteddug	671	14	core	core	NN
cord-306904-8iteddug	671	15	domain	domain	NN
cord-306904-8iteddug	671	16	of	of	IN
cord-306904-8iteddug	671	17	the	the	DT
cord-306904-8iteddug	671	18	Geobacillus	Geobacillus	NNP
cord-306904-8iteddug	671	19	stearothermophilus	stearothermophilus	NN
cord-306904-8iteddug	671	20	GerD	GerD	NNP
cord-306904-8iteddug	671	21	protein	protein	NN
cord-306904-8iteddug	671	22	(	(	-LRB-
cord-306904-8iteddug	671	23	GerD	GerD	NNP
cord-306904-8iteddug	671	24	)	)	-RRB-
cord-306904-8iteddug	671	25	that	that	WDT
cord-306904-8iteddug	671	26	lacks	lack	VBZ
cord-306904-8iteddug	671	27	the	the	DT
cord-306904-8iteddug	671	28	N	n	CD
cord-306904-8iteddug	671	29	-	-	HYPH
cord-306904-8iteddug	671	30	terminal	terminal	NN
cord-306904-8iteddug	671	31	signal	signal	NN
cord-306904-8iteddug	671	32	and	and	CC
cord-306904-8iteddug	671	33	lipobox	lipobox	NN
cord-306904-8iteddug	671	34	sequences	sequence	NNS
cord-306904-8iteddug	672	1	(	(	-LRB-
cord-306904-8iteddug	672	2	residues	residue	NNS
cord-306904-8iteddug	672	3	1	1	CD
cord-306904-8iteddug	672	4	-	-	HYPH
cord-306904-8iteddug	672	5	28	28	CD
cord-306904-8iteddug	672	6	)	)	-RRB-
cord-306904-8iteddug	672	7	,	,	,
cord-306904-8iteddug	672	8	the	the	DT
cord-306904-8iteddug	672	9	H01	H01	NNP
cord-306904-8iteddug	672	10	and	and	CC
cord-306904-8iteddug	672	11	H02	H02	NNP
cord-306904-8iteddug	672	12	helices	helix	NNS
cord-306904-8iteddug	672	13	(	(	-LRB-
cord-306904-8iteddug	672	14	residues	residue	NNS
cord-306904-8iteddug	672	15	,	,	,
cord-306904-8iteddug	672	16	and	and	CC
cord-306904-8iteddug	672	17	the	the	DT
cord-306904-8iteddug	672	18	C	c	NN
cord-306904-8iteddug	672	19	-	-	HYPH
cord-306904-8iteddug	672	20	terminal	terminal	JJ
cord-306904-8iteddug	672	21	acidic	acidic	JJ
cord-306904-8iteddug	672	22	tail	tail	NN
cord-306904-8iteddug	672	23	(	(	-LRB-
cord-306904-8iteddug	672	24	residues	residue	NNS
cord-306904-8iteddug	672	25	[	[	-LRB-
cord-306904-8iteddug	672	26	181	181	CD
cord-306904-8iteddug	672	27	]	]	-RRB-
cord-306904-8iteddug	672	28	[	[	-LRB-
cord-306904-8iteddug	672	29	182	182	CD
cord-306904-8iteddug	672	30	]	]	-RRB-
cord-306904-8iteddug	672	31	[	[	-LRB-
cord-306904-8iteddug	672	32	183	183	CD
cord-306904-8iteddug	672	33	]	]	-RRB-
cord-306904-8iteddug	672	34	[	[	-LRB-
cord-306904-8iteddug	672	35	184	184	CD
cord-306904-8iteddug	672	36	]	]	-RRB-
cord-306904-8iteddug	672	37	[	[	-LRB-
cord-306904-8iteddug	672	38	185	185	CD
cord-306904-8iteddug	672	39	]	]	-RRB-
cord-306904-8iteddug	672	40	[	[	-LRB-
cord-306904-8iteddug	672	41	186	186	CD
cord-306904-8iteddug	672	42	]	]	-RRB-
cord-306904-8iteddug	672	43	[	[	-LRB-
cord-306904-8iteddug	672	44	187	187	CD
cord-306904-8iteddug	672	45	]	]	-RRB-
cord-306904-8iteddug	672	46	[	[	-LRB-
cord-306904-8iteddug	672	47	188	188	CD
cord-306904-8iteddug	672	48	]	]	-RRB-
cord-306904-8iteddug	672	49	[	[	-LRB-
cord-306904-8iteddug	672	50	189	189	CD
cord-306904-8iteddug	672	51	]	]	-RRB-
cord-306904-8iteddug	672	52	[	[	-LRB-
cord-306904-8iteddug	672	53	190	190	CD
cord-306904-8iteddug	672	54	]	]	-RRB-
cord-306904-8iteddug	672	55	[	[	-LRB-
cord-306904-8iteddug	672	56	191	191	CD
cord-306904-8iteddug	672	57	]	]	-RRB-
cord-306904-8iteddug	672	58	[	[	-LRB-
cord-306904-8iteddug	672	59	192	192	CD
cord-306904-8iteddug	672	60	]	]	-RRB-
cord-306904-8iteddug	672	61	[	[	-LRB-
cord-306904-8iteddug	672	62	193	193	CD
cord-306904-8iteddug	672	63	]	]	-RRB-
cord-306904-8iteddug	672	64	[	[	-LRB-
cord-306904-8iteddug	672	65	194	194	CD
cord-306904-8iteddug	672	66	]	]	-RRB-
cord-306904-8iteddug	672	67	[	[	-LRB-
cord-306904-8iteddug	672	68	195	195	CD
cord-306904-8iteddug	672	69	]	]	-RRB-
cord-306904-8iteddug	672	70	.	.	.
cord-306904-8iteddug	673	1	241	241	CD
cord-306904-8iteddug	674	1	By	by	IN
cord-306904-8iteddug	674	2	a	a	DT
cord-306904-8iteddug	674	3	set	set	NN
cord-306904-8iteddug	674	4	of	of	IN
cord-306904-8iteddug	674	5	biophysical	biophysical	JJ
cord-306904-8iteddug	674	6	techniques	technique	NNS
cord-306904-8iteddug	674	7	,	,	,
cord-306904-8iteddug	674	8	this	this	DT
cord-306904-8iteddug	674	9	GerD	GerD	NNP
cord-306904-8iteddug	674	10	60	60	CD
cord-306904-8iteddug	674	11	-	-	SYM
cord-306904-8iteddug	674	12	180	180	CD
cord-306904-8iteddug	674	13	was	be	VBD
cord-306904-8iteddug	674	14	shown	show	VBN
cord-306904-8iteddug	674	15	to	to	TO
cord-306904-8iteddug	674	16	form	form	VB
cord-306904-8iteddug	674	17	a	a	DT
cord-306904-8iteddug	674	18	stable	stable	JJ
cord-306904-8iteddug	674	19	,	,	,
cord-306904-8iteddug	674	20	well	well	RB
cord-306904-8iteddug	674	21	-	-	HYPH
cord-306904-8iteddug	674	22	ordered	order	VBN
cord-306904-8iteddug	674	23	3helix	3helix	CD
cord-306904-8iteddug	674	24	bundle	bundle	NN
cord-306904-8iteddug	674	25	in	in	IN
cord-306904-8iteddug	674	26	solution	solution	NN
cord-306904-8iteddug	674	27	.	.	.
cord-306904-8iteddug	675	1	In	in	IN
cord-306904-8iteddug	675	2	crystal	crystal	NN
cord-306904-8iteddug	675	3	structure	structure	NN
cord-306904-8iteddug	675	4	,	,	,
cord-306904-8iteddug	675	5	GerD	GerD	NNP
cord-306904-8iteddug	675	6	60	60	CD
cord-306904-8iteddug	675	7	-	-	SYM
cord-306904-8iteddug	675	8	180	180	CD
cord-306904-8iteddug	675	9	trimer	trimer	NN
cord-306904-8iteddug	675	10	consists	consist	VBZ
cord-306904-8iteddug	675	11	of	of	IN
cord-306904-8iteddug	675	12	3	3	CD
cord-306904-8iteddug	675	13	parallel	parallel	JJ
cord-306904-8iteddug	675	14	polypeptide	polypeptide	NN
cord-306904-8iteddug	675	15	chains	chain	NNS
cord-306904-8iteddug	675	16	twisted	twist	VBN
cord-306904-8iteddug	675	17	into	into	IN
cord-306904-8iteddug	675	18	a	a	DT
cord-306904-8iteddug	675	19	superhelical	superhelical	JJ
cord-306904-8iteddug	675	20	,	,	,
cord-306904-8iteddug	675	21	right	right	RB
cord-306904-8iteddug	675	22	-	-	HYPH
cord-306904-8iteddug	675	23	handed	handed	JJ
cord-306904-8iteddug	675	24	rope	rope	NN
cord-306904-8iteddug	675	25	(	(	-LRB-
cord-306904-8iteddug	675	26	PDB	PDB	NNP
cord-306904-8iteddug	675	27	ID	ID	NNP
cord-306904-8iteddug	675	28	:	:	:
cord-306904-8iteddug	675	29	4O8W	4o8w	CD
cord-306904-8iteddug	675	30	)	)	-RRB-
cord-306904-8iteddug	675	31	.	.	.
cord-306904-8iteddug	676	1	241	241	CD
cord-306904-8iteddug	677	1	In	in	IN
cord-306904-8iteddug	677	2	this	this	DT
cord-306904-8iteddug	677	3	elongated	elongated	JJ
cord-306904-8iteddug	677	4	trimer	trimer	NN
cord-306904-8iteddug	677	5	,	,	,
cord-306904-8iteddug	677	6	each	each	DT
cord-306904-8iteddug	677	7	of	of	IN
cord-306904-8iteddug	677	8	the	the	DT
cord-306904-8iteddug	677	9	individual	individual	NN
cord-306904-8iteddug	678	1	GerD	GerD	NNP
cord-306904-8iteddug	678	2	60	60	CD
cord-306904-8iteddug	678	3	-	-	SYM
cord-306904-8iteddug	678	4	180	180	CD
cord-306904-8iteddug	678	5	chains	chain	NNS
cord-306904-8iteddug	678	6	forms	form	NNS
cord-306904-8iteddug	678	7	8	8	CD
cord-306904-8iteddug	678	8	helices	helix	NNS
cord-306904-8iteddug	678	9	(	(	-LRB-
cord-306904-8iteddug	678	10	H1	h1	NN
cord-306904-8iteddug	678	11	to	to	IN
cord-306904-8iteddug	678	12	H8	H8	NNP
cord-306904-8iteddug	678	13	)	)	-RRB-
cord-306904-8iteddug	678	14	linked	link	VBN
cord-306904-8iteddug	678	15	by	by	IN
cord-306904-8iteddug	678	16	short	short	JJ
cord-306904-8iteddug	678	17	turns	turn	NNS
cord-306904-8iteddug	678	18	.	.	.
cord-306904-8iteddug	679	1	Structures	structure	NNS
cord-306904-8iteddug	679	2	of	of	IN
cord-306904-8iteddug	679	3	the	the	DT
cord-306904-8iteddug	679	4	individual	individual	JJ
cord-306904-8iteddug	679	5	chains	chain	NNS
cord-306904-8iteddug	679	6	can	can	MD
cord-306904-8iteddug	679	7	be	be	VB
cord-306904-8iteddug	679	8	superimposed	superimpose	VBN
cord-306904-8iteddug	679	9	on	on	IN
cord-306904-8iteddug	679	10	each	each	DT
cord-306904-8iteddug	679	11	other	other	JJ
cord-306904-8iteddug	679	12	except	except	IN
cord-306904-8iteddug	679	13	to	to	IN
cord-306904-8iteddug	679	14	the	the	DT
cord-306904-8iteddug	679	15	loosely	loosely	RB
cord-306904-8iteddug	679	16	packed	pack	VBN
cord-306904-8iteddug	679	17	H8	h8	NN
cord-306904-8iteddug	679	18	helices	helix	NNS
cord-306904-8iteddug	679	19	.	.	.
cord-306904-8iteddug	680	1	Helices	Helices	NNP
cord-306904-8iteddug	680	2	H1-H7	H1-H7	NNP
cord-306904-8iteddug	680	3	in	in	IN
cord-306904-8iteddug	680	4	each	each	DT
cord-306904-8iteddug	680	5	GerD	GerD	NNP
cord-306904-8iteddug	680	6	60	60	CD
cord-306904-8iteddug	680	7	-	-	SYM
cord-306904-8iteddug	680	8	180	180	CD
cord-306904-8iteddug	680	9	chain	chain	NN
cord-306904-8iteddug	680	10	twist	twist	NN
cord-306904-8iteddug	680	11	around	around	IN
cord-306904-8iteddug	680	12	the	the	DT
cord-306904-8iteddug	680	13	central	central	JJ
cord-306904-8iteddug	680	14	axis	axis	NN
cord-306904-8iteddug	680	15	to	to	TO
cord-306904-8iteddug	680	16	form	form	VB
cord-306904-8iteddug	680	17	2	2	CD
cord-306904-8iteddug	680	18	complete	complete	JJ
cord-306904-8iteddug	680	19	turns	turn	NNS
cord-306904-8iteddug	680	20	of	of	IN
cord-306904-8iteddug	680	21	a	a	DT
cord-306904-8iteddug	680	22	right	right	RB
cord-306904-8iteddug	680	23	-	-	HYPH
cord-306904-8iteddug	680	24	handed	handed	JJ
cord-306904-8iteddug	680	25	supercoil	supercoil	NN
cord-306904-8iteddug	680	26	with	with	IN
cord-306904-8iteddug	680	27	a	a	DT
cord-306904-8iteddug	680	28	pitch	pitch	NN
cord-306904-8iteddug	680	29	of	of	IN
cord-306904-8iteddug	680	30	»	»	$
cord-306904-8iteddug	680	31	44A	44a	CD
cord-306904-8iteddug	680	32	.	.	.
cord-306904-8iteddug	681	1	Figure	figure	NN
cord-306904-8iteddug	681	2	24A	24a	CD
cord-306904-8iteddug	681	3	represents	represent	VBZ
cord-306904-8iteddug	681	4	crystal	crystal	NN
cord-306904-8iteddug	681	5	structure	structure	NN
cord-306904-8iteddug	681	6	of	of	IN
cord-306904-8iteddug	681	7	the	the	DT
cord-306904-8iteddug	681	8	GerD	GerD	NNP
cord-306904-8iteddug	681	9	60	60	CD
cord-306904-8iteddug	681	10	-	-	SYM
cord-306904-8iteddug	681	11	180	180	CD
cord-306904-8iteddug	681	12	trimer	trimer	NN
cord-306904-8iteddug	681	13	as	as	IN
cord-306904-8iteddug	681	14	a	a	DT
cord-306904-8iteddug	681	15	molecular	molecular	JJ
cord-306904-8iteddug	681	16	surface	surface	NN
cord-306904-8iteddug	681	17	and	and	CC
cord-306904-8iteddug	681	18	ribbon	ribbon	NN
cord-306904-8iteddug	681	19	diagram	diagram	NN
cord-306904-8iteddug	681	20	and	and	CC
cord-306904-8iteddug	681	21	also	also	RB
cord-306904-8iteddug	681	22	shows	show	VBZ
cord-306904-8iteddug	681	23	the	the	DT
cord-306904-8iteddug	681	24	highly	highly	RB
cord-306904-8iteddug	681	25	extended	extended	JJ
cord-306904-8iteddug	681	26	structure	structure	NN
cord-306904-8iteddug	681	27	of	of	IN
cord-306904-8iteddug	681	28	one	one	CD
cord-306904-8iteddug	681	29	of	of	IN
cord-306904-8iteddug	681	30	the	the	DT
cord-306904-8iteddug	681	31	GerD	GerD	NNP
cord-306904-8iteddug	681	32	60	60	CD
cord-306904-8iteddug	681	33	-	-	SYM
cord-306904-8iteddug	681	34	180	180	CD
cord-306904-8iteddug	681	35	monomers	monomer	NNS
cord-306904-8iteddug	681	36	.	.	.
cord-306904-8iteddug	682	1	241	241	CD
cord-306904-8iteddug	682	2	Analysis	Analysis	NNP
cord-306904-8iteddug	682	3	of	of	IN
cord-306904-8iteddug	682	4	the	the	DT
cord-306904-8iteddug	682	5	overall	overall	JJ
cord-306904-8iteddug	682	6	shapes	shape	NNS
cord-306904-8iteddug	682	7	of	of	IN
cord-306904-8iteddug	682	8	the	the	DT
cord-306904-8iteddug	682	9	highly	highly	RB
cord-306904-8iteddug	682	10	intertwined	intertwine	VBN
cord-306904-8iteddug	682	11	and	and	CC
cord-306904-8iteddug	682	12	extended	extended	JJ
cord-306904-8iteddug	682	13	monomers	monomer	NNS
cord-306904-8iteddug	682	14	within	within	IN
cord-306904-8iteddug	682	15	the	the	DT
cord-306904-8iteddug	682	16	GerD	GerD	NNP
cord-306904-8iteddug	682	17	60	60	CD
cord-306904-8iteddug	682	18	-	-	SYM
cord-306904-8iteddug	682	19	180	180	CD
cord-306904-8iteddug	682	20	trimer	trimer	NN
cord-306904-8iteddug	682	21	suggests	suggest	VBZ
cord-306904-8iteddug	682	22	that	that	IN
cord-306904-8iteddug	682	23	the	the	DT
cord-306904-8iteddug	682	24	formation	formation	NN
cord-306904-8iteddug	682	25	of	of	IN
cord-306904-8iteddug	682	26	this	this	DT
cord-306904-8iteddug	682	27	trimer	trimer	NN
cord-306904-8iteddug	682	28	represents	represent	VBZ
cord-306904-8iteddug	682	29	an	an	DT
cord-306904-8iteddug	682	30	example	example	NN
cord-306904-8iteddug	682	31	of	of	IN
cord-306904-8iteddug	682	32	the	the	DT
cord-306904-8iteddug	682	33	folding	folding	NN
cord-306904-8iteddug	682	34	-	-	HYPH
cord-306904-8iteddug	682	35	uponbinding	uponbinding	NN
cord-306904-8iteddug	682	36	process	process	NN
cord-306904-8iteddug	682	37	.	.	.
cord-306904-8iteddug	683	1	In	in	IN
cord-306904-8iteddug	683	2	agreement	agreement	NN
cord-306904-8iteddug	683	3	with	with	IN
cord-306904-8iteddug	683	4	this	this	DT
cord-306904-8iteddug	683	5	hypothesis	hypothesis	NN
cord-306904-8iteddug	683	6	,	,	,
cord-306904-8iteddug	683	7	Figure	figure	NN
cord-306904-8iteddug	683	8	24B	24b	NN
cord-306904-8iteddug	683	9	shows	show	VBZ
cord-306904-8iteddug	683	10	that	that	IN
cord-306904-8iteddug	683	11	the	the	DT
cord-306904-8iteddug	683	12	core	core	NN
cord-306904-8iteddug	683	13	domain	domain	NN
cord-306904-8iteddug	683	14	of	of	IN
cord-306904-8iteddug	683	15	the	the	DT
cord-306904-8iteddug	683	16	Geobacillus	Geobacillus	NNP
cord-306904-8iteddug	683	17	stearothermophilus	stearothermophilus	NN
cord-306904-8iteddug	683	18	GerD	GerD	NNP
cord-306904-8iteddug	683	19	protein	protein	NN
cord-306904-8iteddug	683	20	(	(	-LRB-
cord-306904-8iteddug	683	21	UniProt	UniProt	NNP
cord-306904-8iteddug	683	22	ID	ID	NNP
cord-306904-8iteddug	683	23	:	:	:
cord-306904-8iteddug	683	24	Q5L3Q1	Q5L3Q1	NNS
cord-306904-8iteddug	683	25	)	)	-RRB-
cord-306904-8iteddug	683	26	is	be	VBZ
cord-306904-8iteddug	683	27	mostly	mostly	RB
cord-306904-8iteddug	683	28	disordered	disordered	JJ
cord-306904-8iteddug	683	29	.	.	.
cord-306904-8iteddug	684	1	Prokaryotic	prokaryotic	JJ
cord-306904-8iteddug	684	2	ubiquitin	ubiquitin	NN
cord-306904-8iteddug	684	3	-	-	HYPH
cord-306904-8iteddug	684	4	like	like	JJ
cord-306904-8iteddug	684	5	protein	protein	NN
cord-306904-8iteddug	684	6	(	(	-LRB-
cord-306904-8iteddug	684	7	Pup	Pup	NNP
cord-306904-8iteddug	684	8	)	)	-RRB-
cord-306904-8iteddug	684	9	,	,	,
cord-306904-8iteddug	684	10	the	the	DT
cord-306904-8iteddug	684	11	Pup	Pup	NNP
cord-306904-8iteddug	684	12	ligase	ligase	NN
cord-306904-8iteddug	684	13	PafA	PafA	NNP
cord-306904-8iteddug	684	14	and	and	CC
cord-306904-8iteddug	684	15	bacterial	bacterial	JJ
cord-306904-8iteddug	684	16	proteasome	proteasome	VBN
cord-306904-8iteddug	685	1	Forer	Forer	NNP
cord-306904-8iteddug	685	2	et	et	NNP
cord-306904-8iteddug	685	3	al	al	NNP
cord-306904-8iteddug	685	4	.	.	NNP
cord-306904-8iteddug	685	5	investigated	investigate	VBD
cord-306904-8iteddug	685	6	the	the	DT
cord-306904-8iteddug	685	7	interaction	interaction	NN
cord-306904-8iteddug	685	8	between	between	IN
cord-306904-8iteddug	685	9	the	the	DT
cord-306904-8iteddug	685	10	prokaryotic	prokaryotic	JJ
cord-306904-8iteddug	685	11	ubiquitin	ubiquitin	NN
cord-306904-8iteddug	685	12	-	-	HYPH
cord-306904-8iteddug	685	13	like	like	JJ
cord-306904-8iteddug	685	14	protein	protein	NN
cord-306904-8iteddug	685	15	(	(	-LRB-
cord-306904-8iteddug	685	16	Pup	Pup	NNP
cord-306904-8iteddug	685	17	)	)	-RRB-
cord-306904-8iteddug	685	18	,	,	,
cord-306904-8iteddug	685	19	the	the	DT
cord-306904-8iteddug	685	20	proteasome	proteasome	NN
cord-306904-8iteddug	685	21	regulatory	regulatory	JJ
cord-306904-8iteddug	685	22	subunit	subunit	NN
cord-306904-8iteddug	685	23	Mpa	Mpa	NNP
cord-306904-8iteddug	685	24	(	(	-LRB-
cord-306904-8iteddug	685	25	mycobacterium	mycobacterium	NN
cord-306904-8iteddug	685	26	proteasome	proteasome	VBD
cord-306904-8iteddug	685	27	ATPase	ATPase	NNP
cord-306904-8iteddug	685	28	)	)	-RRB-
cord-306904-8iteddug	685	29	,	,	,
cord-306904-8iteddug	685	30	and	and	CC
cord-306904-8iteddug	685	31	proteasome	proteasome	VBN
cord-306904-8iteddug	685	32	accessory	accessory	NN
cord-306904-8iteddug	685	33	factor	factor	NN
cord-306904-8iteddug	686	1	A	a	DT
cord-306904-8iteddug	686	2	(	(	-LRB-
cord-306904-8iteddug	686	3	PafA	PafA	NNP
cord-306904-8iteddug	686	4	)	)	-RRB-
cord-306904-8iteddug	686	5	,	,	,
cord-306904-8iteddug	686	6	an	an	DT
cord-306904-8iteddug	686	7	enzyme	enzyme	NN
cord-306904-8iteddug	686	8	that	that	WDT
cord-306904-8iteddug	686	9	forms	form	VBZ
cord-306904-8iteddug	686	10	an	an	DT
cord-306904-8iteddug	686	11	isopeptide	isopeptide	NN
cord-306904-8iteddug	686	12	bond	bond	NN
cord-306904-8iteddug	686	13	between	between	IN
cord-306904-8iteddug	686	14	the	the	DT
cord-306904-8iteddug	686	15	g	g	NN
cord-306904-8iteddug	686	16	-	-	HYPH
cord-306904-8iteddug	686	17	carboxylate	carboxylate	NNP
cord-306904-8iteddug	686	18	of	of	IN
cord-306904-8iteddug	686	19	a	a	DT
cord-306904-8iteddug	686	20	glutamate	glutamate	NN
cord-306904-8iteddug	686	21	at	at	IN
cord-306904-8iteddug	686	22	the	the	DT
cord-306904-8iteddug	686	23	C	c	NN
cord-306904-8iteddug	686	24	-	-	HYPH
cord-306904-8iteddug	686	25	terminus	terminus	NN
cord-306904-8iteddug	686	26	of	of	IN
cord-306904-8iteddug	686	27	Pup	Pup	NNP
cord-306904-8iteddug	686	28	and	and	CC
cord-306904-8iteddug	686	29	the	the	DT
cord-306904-8iteddug	686	30	e	e	NN
cord-306904-8iteddug	686	31	-	-	NN
cord-306904-8iteddug	686	32	amine	amine	NN
cord-306904-8iteddug	686	33	of	of	IN
cord-306904-8iteddug	686	34	a	a	DT
cord-306904-8iteddug	686	35	substrate	substrate	JJ
cord-306904-8iteddug	686	36	lysine	lysine	NN
cord-306904-8iteddug	686	37	.	.	.
cord-306904-8iteddug	687	1	247	247	CD
cord-306904-8iteddug	688	1	The	the	DT
cord-306904-8iteddug	688	2	authors	author	NNS
cord-306904-8iteddug	688	3	show	show	VBP
cord-306904-8iteddug	688	4	that	that	IN
cord-306904-8iteddug	688	5	Pup	Pup	NNP
cord-306904-8iteddug	688	6	is	be	VBZ
cord-306904-8iteddug	688	7	involved	involve	VBN
cord-306904-8iteddug	688	8	in	in	IN
cord-306904-8iteddug	688	9	simultaneous	simultaneous	JJ
cord-306904-8iteddug	688	10	interaction	interaction	NN
cord-306904-8iteddug	688	11	with	with	IN
cord-306904-8iteddug	688	12	both	both	CC
cord-306904-8iteddug	688	13	Mpa	Mpa	NNP
cord-306904-8iteddug	688	14	and	and	CC
cord-306904-8iteddug	688	15	PafA	PafA	NNP
cord-306904-8iteddug	688	16	,	,	,
cord-306904-8iteddug	688	17	and	and	CC
cord-306904-8iteddug	688	18	that	that	IN
cord-306904-8iteddug	688	19	Mpa	Mpa	NNP
cord-306904-8iteddug	688	20	forms	form	VBZ
cord-306904-8iteddug	688	21	a	a	DT
cord-306904-8iteddug	688	22	complex	complex	NN
cord-306904-8iteddug	688	23	with	with	IN
cord-306904-8iteddug	688	24	PafA	PafA	NNP
cord-306904-8iteddug	688	25	,	,	,
cord-306904-8iteddug	688	26	suggesting	suggest	VBG
cord-306904-8iteddug	688	27	that	that	IN
cord-306904-8iteddug	688	28	PafA	PafA	NNP
cord-306904-8iteddug	688	29	and	and	CC
cord-306904-8iteddug	688	30	the	the	DT
cord-306904-8iteddug	688	31	proteasome	proteasome	NN
cord-306904-8iteddug	688	32	acts	act	VBZ
cord-306904-8iteddug	688	33	as	as	IN
cord-306904-8iteddug	688	34	a	a	DT
cord-306904-8iteddug	688	35	modular	modular	JJ
cord-306904-8iteddug	688	36	machine	machine	NN
cord-306904-8iteddug	688	37	for	for	IN
cord-306904-8iteddug	688	38	the	the	DT
cord-306904-8iteddug	688	39	tagging	tagging	NN
cord-306904-8iteddug	688	40	and	and	CC
cord-306904-8iteddug	688	41	degradation	degradation	NN
cord-306904-8iteddug	688	42	of	of	IN
cord-306904-8iteddug	688	43	cytoplasmic	cytoplasmic	JJ
cord-306904-8iteddug	688	44	proteins	protein	NNS
cord-306904-8iteddug	688	45	.	.	.
cord-306904-8iteddug	689	1	247	247	CD
cord-306904-8iteddug	689	2	Figure	figure	NN
cord-306904-8iteddug	689	3	25A	25a	NN
cord-306904-8iteddug	689	4	represents	represent	VBZ
cord-306904-8iteddug	689	5	a	a	DT
cord-306904-8iteddug	689	6	crystal	crystal	JJ
cord-306904-8iteddug	689	7	structure	structure	NN
cord-306904-8iteddug	689	8	of	of	IN
cord-306904-8iteddug	689	9	3	3	CD
cord-306904-8iteddug	689	10	Pup	Pup	NNP
cord-306904-8iteddug	689	11	molecules	molecule	NNS
cord-306904-8iteddug	689	12	bound	bind	VBN
cord-306904-8iteddug	689	13	to	to	IN
cord-306904-8iteddug	689	14	the	the	DT
cord-306904-8iteddug	689	15	Mpa	Mpa	NNP
cord-306904-8iteddug	689	16	hexamer	hexamer	NN
cord-306904-8iteddug	689	17	(	(	-LRB-
cord-306904-8iteddug	689	18	PDB	PDB	NNP
cord-306904-8iteddug	689	19	ID	ID	NNP
cord-306904-8iteddug	689	20	:	:	:
cord-306904-8iteddug	689	21	3M9D	3m9d	CD
cord-306904-8iteddug	689	22	)	)	-RRB-
cord-306904-8iteddug	689	23	,	,	,
cord-306904-8iteddug	689	24	and	and	CC
cord-306904-8iteddug	689	25	the	the	DT
cord-306904-8iteddug	689	26	results	result	NNS
cord-306904-8iteddug	689	27	of	of	IN
cord-306904-8iteddug	689	28	disorder	disorder	NN
cord-306904-8iteddug	689	29	prediction	prediction	NN
cord-306904-8iteddug	689	30	for	for	IN
cord-306904-8iteddug	689	31	the	the	DT
cord-306904-8iteddug	689	32	Mycobacterium	Mycobacterium	NNP
cord-306904-8iteddug	689	33	tuberculosis	tuberculosis	NN
cord-306904-8iteddug	689	34	Pup	pup	NN
cord-306904-8iteddug	689	35	(	(	-LRB-
cord-306904-8iteddug	689	36	UniProt	UniProt	NNP
cord-306904-8iteddug	689	37	ID	ID	NNP
cord-306904-8iteddug	689	38	:	:	:
cord-306904-8iteddug	689	39	P9WHN5	P9WHN5	NNS
cord-306904-8iteddug	689	40	)	)	-RRB-
cord-306904-8iteddug	689	41	are	be	VBP
cord-306904-8iteddug	689	42	shown	show	VBN
cord-306904-8iteddug	689	43	in	in	IN
cord-306904-8iteddug	689	44	Figure	figure	NN
cord-306904-8iteddug	689	45	25B	25b	NN
cord-306904-8iteddug	689	46	.	.	.
cord-306904-8iteddug	690	1	Pup	pup	NN
cord-306904-8iteddug	690	2	is	be	VBZ
cord-306904-8iteddug	690	3	obviously	obviously	RB
cord-306904-8iteddug	690	4	a	a	DT
cord-306904-8iteddug	690	5	highly	highly	RB
cord-306904-8iteddug	690	6	disordered	disordered	JJ
cord-306904-8iteddug	690	7	protein	protein	NN
cord-306904-8iteddug	690	8	that	that	WDT
cord-306904-8iteddug	690	9	partially	partially	RB
cord-306904-8iteddug	690	10	folds	fold	VBZ
cord-306904-8iteddug	690	11	at	at	IN
cord-306904-8iteddug	690	12	binding	bind	VBG
cord-306904-8iteddug	690	13	.	.	.
cord-306904-8iteddug	691	1	In	in	IN
cord-306904-8iteddug	691	2	fact	fact	NN
cord-306904-8iteddug	691	3	,	,	,
cord-306904-8iteddug	691	4	of	of	IN
cord-306904-8iteddug	691	5	68	68	CD
cord-306904-8iteddug	691	6	residues	residue	NNS
cord-306904-8iteddug	691	7	used	use	VBN
cord-306904-8iteddug	691	8	in	in	IN
cord-306904-8iteddug	691	9	the	the	DT
cord-306904-8iteddug	691	10	crystallization	crystallization	NN
cord-306904-8iteddug	691	11	experiment	experiment	NN
cord-306904-8iteddug	691	12	,	,	,
cord-306904-8iteddug	691	13	only	only	RB
cord-306904-8iteddug	691	14	31	31	CD
cord-306904-8iteddug	691	15	are	be	VBP
cord-306904-8iteddug	691	16	visible	visible	JJ
cord-306904-8iteddug	691	17	in	in	IN
cord-306904-8iteddug	691	18	structure	structure	NN
cord-306904-8iteddug	691	19	,	,	,
cord-306904-8iteddug	691	20	whereas	whereas	IN
cord-306904-8iteddug	691	21	remaining	remain	VBG
cord-306904-8iteddug	691	22	37	37	CD
cord-306904-8iteddug	691	23	residues	residue	NNS
cord-306904-8iteddug	691	24	(	(	-LRB-
cord-306904-8iteddug	691	25	1	1	CD
cord-306904-8iteddug	691	26	-	-	SYM
cord-306904-8iteddug	691	27	20	20	CD
cord-306904-8iteddug	691	28	and	and	CC
cord-306904-8iteddug	691	29	52	52	CD
cord-306904-8iteddug	691	30	-	-	SYM
cord-306904-8iteddug	691	31	68	68	CD
cord-306904-8iteddug	691	32	)	)	-RRB-
cord-306904-8iteddug	691	33	are	be	VBP
cord-306904-8iteddug	691	34	located	locate	VBN
cord-306904-8iteddug	691	35	within	within	IN
cord-306904-8iteddug	691	36	the	the	DT
cord-306904-8iteddug	691	37	regions	region	NNS
cord-306904-8iteddug	691	38	of	of	IN
cord-306904-8iteddug	691	39	missing	miss	VBG
cord-306904-8iteddug	691	40	electron	electron	NN
cord-306904-8iteddug	691	41	density	density	NN
cord-306904-8iteddug	691	42	.	.	.
cord-306904-8iteddug	692	1	According	accord	VBG
cord-306904-8iteddug	692	2	to	to	IN
cord-306904-8iteddug	692	3	the	the	DT
cord-306904-8iteddug	692	4	ANCHOR	anchor	NN
cord-306904-8iteddug	692	5	analysis	analysis	NN
cord-306904-8iteddug	692	6	,	,	,
cord-306904-8iteddug	692	7	Pup	Pup	NNP
cord-306904-8iteddug	692	8	possesses	possess	VBZ
cord-306904-8iteddug	692	9	2	2	CD
cord-306904-8iteddug	692	10	disorder	disorder	NN
cord-306904-8iteddug	692	11	-	-	HYPH
cord-306904-8iteddug	692	12	based	base	VBN
cord-306904-8iteddug	692	13	binding	binding	NN
cord-306904-8iteddug	692	14	regions	region	NNS
cord-306904-8iteddug	692	15	,	,	,
cord-306904-8iteddug	692	16	residues	residue	NNS
cord-306904-8iteddug	692	17	1	1	CD
cord-306904-8iteddug	692	18	-	-	SYM
cord-306904-8iteddug	692	19	15	15	CD
cord-306904-8iteddug	692	20	and	and	CC
cord-306904-8iteddug	692	21	34	34	CD
cord-306904-8iteddug	692	22	-	-	SYM
cord-306904-8iteddug	692	23	64	64	CD
cord-306904-8iteddug	692	24	.	.	.
cord-306904-8iteddug	693	1	Curiously	curiously	RB
cord-306904-8iteddug	693	2	,	,	,
cord-306904-8iteddug	693	3	Forer	Forer	NNP
cord-306904-8iteddug	693	4	et	et	NNP
cord-306904-8iteddug	693	5	al	al	NNP
cord-306904-8iteddug	693	6	.	.	NNP
cord-306904-8iteddug	693	7	suggested	suggest	VBD
cord-306904-8iteddug	693	8	that	that	IN
cord-306904-8iteddug	693	9	Pup	Pup	NNP
cord-306904-8iteddug	693	10	has	have	VBZ
cord-306904-8iteddug	693	11	2	2	CD
cord-306904-8iteddug	693	12	binding	bind	VBG
cord-306904-8iteddug	693	13	sites	site	NNS
cord-306904-8iteddug	693	14	for	for	IN
cord-306904-8iteddug	693	15	RafA	RafA	NNP
cord-306904-8iteddug	693	16	located	locate	VBN
cord-306904-8iteddug	693	17	at	at	IN
cord-306904-8iteddug	693	18	residues	residue	NNS
cord-306904-8iteddug	693	19	38	38	CD
cord-306904-8iteddug	693	20	-	-	SYM
cord-306904-8iteddug	693	21	47	47	CD
cord-306904-8iteddug	693	22	and	and	CC
cord-306904-8iteddug	693	23	51	51	CD
cord-306904-8iteddug	693	24	-	-	SYM
cord-306904-8iteddug	693	25	58	58	CD
cord-306904-8iteddug	693	26	,	,	,
cord-306904-8iteddug	693	27	and	and	CC
cord-306904-8iteddug	693	28	that	that	IN
cord-306904-8iteddug	693	29	the	the	DT
cord-306904-8iteddug	693	30	first	first	JJ
cord-306904-8iteddug	693	31	RafA	RafA	NNP
cord-306904-8iteddug	693	32	binding	bind	VBG
cord-306904-8iteddug	693	33	site	site	NN
cord-306904-8iteddug	693	34	is	be	VBZ
cord-306904-8iteddug	693	35	overlapped	overlap	VBN
cord-306904-8iteddug	693	36	with	with	IN
cord-306904-8iteddug	693	37	the	the	DT
cord-306904-8iteddug	693	38	region	region	NN
cord-306904-8iteddug	693	39	responsible	responsible	JJ
cord-306904-8iteddug	693	40	for	for	IN
cord-306904-8iteddug	693	41	the	the	DT
cord-306904-8iteddug	693	42	Mpa	Mpa	NNP
cord-306904-8iteddug	693	43	binding	binding	NN
cord-306904-8iteddug	693	44	(	(	-LRB-
cord-306904-8iteddug	693	45	residues	residue	NNS
cord-306904-8iteddug	693	46	21	21	CD
cord-306904-8iteddug	693	47	-	-	SYM
cord-306904-8iteddug	693	48	51	51	CD
cord-306904-8iteddug	693	49	)	)	-RRB-
cord-306904-8iteddug	693	50	.	.	.
cord-306904-8iteddug	694	1	247	247	CD
cord-306904-8iteddug	695	1	The	the	DT
cord-306904-8iteddug	695	2	nucleolar	nucleolar	JJ
cord-306904-8iteddug	695	3	PICT-1	PICT-1	NNP
cord-306904-8iteddug	695	4	/	/	SYM
cord-306904-8iteddug	695	5	GLTSCR2	GLTSCR2	NNP
cord-306904-8iteddug	695	6	protein	protein	NN
cord-306904-8iteddug	695	7	Borodianskiy	Borodianskiy	NNP
cord-306904-8iteddug	695	8	-	-	HYPH
cord-306904-8iteddug	695	9	Shteinberg	Shteinberg	NNP
cord-306904-8iteddug	695	10	et	et	NNP
cord-306904-8iteddug	695	11	al	al	NNP
cord-306904-8iteddug	695	12	.	.	.
cord-306904-8iteddug	695	13	studied	study	VBD
cord-306904-8iteddug	695	14	self	self	NN
cord-306904-8iteddug	695	15	-	-	HYPH
cord-306904-8iteddug	695	16	association	association	NN
cord-306904-8iteddug	695	17	of	of	IN
cord-306904-8iteddug	695	18	the	the	DT
cord-306904-8iteddug	695	19	human	human	JJ
cord-306904-8iteddug	695	20	protein	protein	NN
cord-306904-8iteddug	695	21	interacting	interact	VBG
cord-306904-8iteddug	695	22	with	with	IN
cord-306904-8iteddug	695	23	carboxyl	carboxyl	NN
cord-306904-8iteddug	695	24	terminus-1	terminus-1	NN
cord-306904-8iteddug	695	25	(	(	-LRB-
cord-306904-8iteddug	695	26	PICT-1	PICT-1	NNP
cord-306904-8iteddug	695	27	)	)	-RRB-
cord-306904-8iteddug	695	28	,	,	,
cord-306904-8iteddug	695	29	also	also	RB
cord-306904-8iteddug	695	30	known	know	VBN
cord-306904-8iteddug	695	31	as	as	IN
cord-306904-8iteddug	695	32	the	the	DT
cord-306904-8iteddug	695	33	glioma	glioma	NN
cord-306904-8iteddug	695	34	tumor	tumor	NN
cord-306904-8iteddug	695	35	suppressor	suppressor	NN
cord-306904-8iteddug	695	36	candidate	candidate	NN
cord-306904-8iteddug	695	37	region	region	NN
cord-306904-8iteddug	695	38	2	2	CD
cord-306904-8iteddug	695	39	gene	gene	NN
cord-306904-8iteddug	695	40	product	product	NN
cord-306904-8iteddug	695	41	(	(	-LRB-
cord-306904-8iteddug	695	42	GLTSCR2	GLTSCR2	NNP
cord-306904-8iteddug	695	43	)	)	-RRB-
cord-306904-8iteddug	695	44	,	,	,
cord-306904-8iteddug	695	45	a	a	DT
cord-306904-8iteddug	695	46	nucleolar	nucleolar	JJ
cord-306904-8iteddug	695	47	protein	protein	NN
cord-306904-8iteddug	695	48	with	with	IN
cord-306904-8iteddug	695	49	unknown	unknown	JJ
cord-306904-8iteddug	695	50	function	function	NN
cord-306904-8iteddug	695	51	.	.	.
cord-306904-8iteddug	696	1	248	248	CD
cord-306904-8iteddug	696	2	PICT-1/	pict-1/	CD
cord-306904-8iteddug	696	3	GLTSCR2	GLTSCR2	NNP
cord-306904-8iteddug	696	4	is	be	VBZ
cord-306904-8iteddug	696	5	conserved	conserve	VBN
cord-306904-8iteddug	696	6	among	among	IN
cord-306904-8iteddug	696	7	eukaryotes	eukaryote	NNS
cord-306904-8iteddug	696	8	and	and	CC
cord-306904-8iteddug	696	9	is	be	VBZ
cord-306904-8iteddug	696	10	assumed	assume	VBN
cord-306904-8iteddug	696	11	to	to	TO
cord-306904-8iteddug	696	12	be	be	VB
cord-306904-8iteddug	696	13	essential	essential	JJ
cord-306904-8iteddug	696	14	for	for	IN
cord-306904-8iteddug	696	15	preimplantation	preimplantation	NN
cord-306904-8iteddug	696	16	embryogenesis	embryogenesis	NN
cord-306904-8iteddug	696	17	and	and	CC
cord-306904-8iteddug	696	18	embryonic	embryonic	JJ
cord-306904-8iteddug	696	19	stem	stem	NN
cord-306904-8iteddug	696	20	cell	cell	NN
cord-306904-8iteddug	696	21	survival	survival	NN
cord-306904-8iteddug	696	22	and	and	CC
cord-306904-8iteddug	696	23	proliferation	proliferation	NN
cord-306904-8iteddug	696	24	.	.	.
cord-306904-8iteddug	697	1	249	249	CD
cord-306904-8iteddug	698	1	It	-PRON-	PRP
cord-306904-8iteddug	698	2	was	be	VBD
cord-306904-8iteddug	698	3	suggested	suggest	VBN
cord-306904-8iteddug	698	4	that	that	IN
cord-306904-8iteddug	698	5	PICT-1	PICT-1	NNP
cord-306904-8iteddug	698	6	might	may	MD
cord-306904-8iteddug	698	7	act	act	VB
cord-306904-8iteddug	698	8	as	as	IN
cord-306904-8iteddug	698	9	a	a	DT
cord-306904-8iteddug	698	10	potential	potential	JJ
cord-306904-8iteddug	698	11	tumor	tumor	NN
cord-306904-8iteddug	698	12	suppressor	suppressor	NN
cord-306904-8iteddug	698	13	,	,	,
cord-306904-8iteddug	698	14	being	be	VBG
cord-306904-8iteddug	698	15	involved	involve	VBN
cord-306904-8iteddug	698	16	in	in	IN
cord-306904-8iteddug	698	17	interaction	interaction	NN
cord-306904-8iteddug	698	18	with	with	IN
cord-306904-8iteddug	698	19	the	the	DT
cord-306904-8iteddug	698	20	Cterminal	Cterminal	NNP
cord-306904-8iteddug	698	21	region	region	NN
cord-306904-8iteddug	698	22	of	of	IN
cord-306904-8iteddug	698	23	the	the	DT
cord-306904-8iteddug	698	24	tumor	tumor	NN
cord-306904-8iteddug	698	25	suppressor	suppressor	NN
cord-306904-8iteddug	698	26	phosphatase	phosphatase	NN
cord-306904-8iteddug	698	27	and	and	CC
cord-306904-8iteddug	698	28	tensin	tensin	NNP
cord-306904-8iteddug	698	29	homolog	homolog	NN
cord-306904-8iteddug	698	30	(	(	-LRB-
cord-306904-8iteddug	698	31	PTEN	PTEN	NNP
cord-306904-8iteddug	698	32	)	)	-RRB-
cord-306904-8iteddug	698	33	,	,	,
cord-306904-8iteddug	698	34	promoting	promote	VBG
cord-306904-8iteddug	698	35	its	-PRON-	PRP$
cord-306904-8iteddug	698	36	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	698	37	and	and	CC
cord-306904-8iteddug	698	38	stabilization	stabilization	NN
cord-306904-8iteddug	698	39	.	.	.
cord-306904-8iteddug	699	1	250	250	CD
cord-306904-8iteddug	700	1	It	-PRON-	PRP
cord-306904-8iteddug	700	2	was	be	VBD
cord-306904-8iteddug	700	3	also	also	RB
cord-306904-8iteddug	700	4	suggested	suggest	VBN
cord-306904-8iteddug	700	5	that	that	IN
cord-306904-8iteddug	700	6	PICT-1	PICT-1	NNP
cord-306904-8iteddug	700	7	can	can	MD
cord-306904-8iteddug	700	8	function	function	VB
cord-306904-8iteddug	700	9	as	as	IN
cord-306904-8iteddug	700	10	an	an	DT
cord-306904-8iteddug	700	11	oncogene	oncogene	NN
cord-306904-8iteddug	700	12	through	through	IN
cord-306904-8iteddug	700	13	the	the	DT
cord-306904-8iteddug	700	14	inhibition	inhibition	NN
cord-306904-8iteddug	700	15	of	of	IN
cord-306904-8iteddug	700	16	p53	p53	NN
cord-306904-8iteddug	700	17	.	.	.
cord-306904-8iteddug	701	1	249	249	CD
cord-306904-8iteddug	701	2	Figure	figure	NN
cord-306904-8iteddug	701	3	26A	26a	NN
cord-306904-8iteddug	701	4	represents	represent	VBZ
cord-306904-8iteddug	701	5	the	the	DT
cord-306904-8iteddug	701	6	results	result	NNS
cord-306904-8iteddug	701	7	of	of	IN
cord-306904-8iteddug	701	8	the	the	DT
cord-306904-8iteddug	701	9	evaluation	evaluation	NN
cord-306904-8iteddug	701	10	of	of	IN
cord-306904-8iteddug	701	11	the	the	DT
cord-306904-8iteddug	701	12	interactivity	interactivity	NN
cord-306904-8iteddug	701	13	of	of	IN
cord-306904-8iteddug	701	14	the	the	DT
cord-306904-8iteddug	701	15	human	human	JJ
cord-306904-8iteddug	701	16	PICT-1	PICT-1	NNP
cord-306904-8iteddug	701	17	/	/	SYM
cord-306904-8iteddug	701	18	GLTSCR2	GLTSCR2	NNP
cord-306904-8iteddug	702	1	(	(	-LRB-
cord-306904-8iteddug	702	2	UniProt	UniProt	NNP
cord-306904-8iteddug	702	3	ID	ID	NNP
cord-306904-8iteddug	702	4	:	:	:
cord-306904-8iteddug	703	1	Q9NZM5	Q9NZM5	NNP
cord-306904-8iteddug	703	2	)	)	-RRB-
cord-306904-8iteddug	703	3	by	by	IN
cord-306904-8iteddug	703	4	STRING	string	NN
cord-306904-8iteddug	703	5	and	and	CC
cord-306904-8iteddug	703	6	shows	show	VBZ
cord-306904-8iteddug	703	7	a	a	DT
cord-306904-8iteddug	703	8	dense	dense	JJ
cord-306904-8iteddug	703	9	interaction	interaction	NN
cord-306904-8iteddug	703	10	network	network	NN
cord-306904-8iteddug	703	11	of	of	IN
cord-306904-8iteddug	703	12	this	this	DT
cord-306904-8iteddug	703	13	intriguing	intriguing	JJ
cord-306904-8iteddug	703	14	protein	protein	NN
cord-306904-8iteddug	703	15	.	.	.
cord-306904-8iteddug	704	1	Figure	figure	NN
cord-306904-8iteddug	704	2	26B	26B	NNS
cord-306904-8iteddug	704	3	provides	provide	VBZ
cord-306904-8iteddug	704	4	an	an	DT
cord-306904-8iteddug	704	5	explanation	explanation	NN
cord-306904-8iteddug	704	6	for	for	IN
cord-306904-8iteddug	704	7	the	the	DT
cord-306904-8iteddug	704	8	binding	binding	JJ
cord-306904-8iteddug	704	9	promiscuity	promiscuity	NN
cord-306904-8iteddug	704	10	of	of	IN
cord-306904-8iteddug	704	11	PICT-1	PICT-1	NNP
cord-306904-8iteddug	704	12	by	by	IN
cord-306904-8iteddug	704	13	showing	show	VBG
cord-306904-8iteddug	704	14	that	that	IN
cord-306904-8iteddug	704	15	this	this	DT
cord-306904-8iteddug	704	16	protein	protein	NN
cord-306904-8iteddug	704	17	is	be	VBZ
cord-306904-8iteddug	704	18	predicted	predict	VBN
cord-306904-8iteddug	704	19	to	to	TO
cord-306904-8iteddug	704	20	be	be	VB
cord-306904-8iteddug	704	21	highly	highly	RB
cord-306904-8iteddug	704	22	disordered	disordered	JJ
cord-306904-8iteddug	704	23	.	.	.
cord-306904-8iteddug	705	1	Recognition	recognition	NN
cord-306904-8iteddug	705	2	of	of	IN
cord-306904-8iteddug	705	3	modified	modify	VBN
cord-306904-8iteddug	705	4	tRNA	trna	NN
cord-306904-8iteddug	705	5	by	by	IN
cord-306904-8iteddug	705	6	the	the	DT
cord-306904-8iteddug	705	7	HIV-1	HIV-1	NNP
cord-306904-8iteddug	705	8	nucleocapsid	nucleocapsid	NN
cord-306904-8iteddug	705	9	protein	protein	NN
cord-306904-8iteddug	705	10	p7	p7	RB
cord-306904-8iteddug	705	11	and	and	CC
cord-306904-8iteddug	705	12	related	related	JJ
cord-306904-8iteddug	705	13	peptides	peptide	NNS
cord-306904-8iteddug	706	1	Spears	Spears	NNPS
cord-306904-8iteddug	706	2	et	et	NNP
cord-306904-8iteddug	706	3	al	al	NNP
cord-306904-8iteddug	706	4	.	.	.
cord-306904-8iteddug	706	5	studied	study	VBD
cord-306904-8iteddug	706	6	the	the	DT
cord-306904-8iteddug	706	7	molecular	molecular	JJ
cord-306904-8iteddug	706	8	mechanisms	mechanism	NNS
cord-306904-8iteddug	706	9	underlying	underlie	VBG
cord-306904-8iteddug	706	10	specific	specific	JJ
cord-306904-8iteddug	706	11	recognition	recognition	NN
cord-306904-8iteddug	706	12	of	of	IN
cord-306904-8iteddug	706	13	highly	highly	RB
cord-306904-8iteddug	706	14	post	post	JJ
cord-306904-8iteddug	706	15	-	-	JJ
cord-306904-8iteddug	706	16	transcriptionally	transcriptionally	RB
cord-306904-8iteddug	706	17	modified	modify	VBN
cord-306904-8iteddug	706	18	human	human	NN
cord-306904-8iteddug	706	19	tRNA	trna	NN
cord-306904-8iteddug	706	20	Lys3	Lys3	NNP
cord-306904-8iteddug	706	21	UUU	UUU	NNP
cord-306904-8iteddug	706	22	(	(	-LRB-
cord-306904-8iteddug	706	23	which	which	WDT
cord-306904-8iteddug	706	24	is	be	VBZ
cord-306904-8iteddug	706	25	the	the	DT
cord-306904-8iteddug	706	26	primer	primer	NN
cord-306904-8iteddug	706	27	for	for	IN
cord-306904-8iteddug	706	28	HIV	HIV	NNP
cord-306904-8iteddug	706	29	replication	replication	NN
cord-306904-8iteddug	706	30	)	)	-RRB-
cord-306904-8iteddug	706	31	by	by	IN
cord-306904-8iteddug	706	32	the	the	DT
cord-306904-8iteddug	706	33	HIV-1	HIV-1	NNP
cord-306904-8iteddug	706	34	nucleocapsid	nucleocapsid	NN
cord-306904-8iteddug	706	35	protein	protein	NN
cord-306904-8iteddug	706	36	p7	p7	RB
cord-306904-8iteddug	706	37	.	.	.
cord-306904-8iteddug	707	1	251	251	CD
cord-306904-8iteddug	708	1	It	-PRON-	PRP
cord-306904-8iteddug	708	2	is	be	VBZ
cord-306904-8iteddug	708	3	known	know	VBN
cord-306904-8iteddug	708	4	that	that	IN
cord-306904-8iteddug	708	5	p7	p7	RB
cord-306904-8iteddug	708	6	recruits	recruit	VBZ
cord-306904-8iteddug	708	7	htRNA	htrna	ADD
cord-306904-8iteddug	709	1	Lys3	Lys3	NNP
cord-306904-8iteddug	709	2	UUU	UUU	NNP
cord-306904-8iteddug	709	3	from	from	IN
cord-306904-8iteddug	709	4	the	the	DT
cord-306904-8iteddug	709	5	host	host	NN
cord-306904-8iteddug	709	6	cell	cell	NN
cord-306904-8iteddug	709	7	by	by	IN
cord-306904-8iteddug	709	8	binding	bind	VBG
cord-306904-8iteddug	709	9	to	to	IN
cord-306904-8iteddug	709	10	and	and	CC
cord-306904-8iteddug	709	11	remodeling	remodel	VBG
cord-306904-8iteddug	709	12	the	the	DT
cord-306904-8iteddug	709	13	tRNA	tRNA	NNP
cord-306904-8iteddug	709	14	structure	structure	NN
cord-306904-8iteddug	709	15	.	.	.
cord-306904-8iteddug	710	1	An	an	DT
cord-306904-8iteddug	710	2	intrigue	intrigue	NN
cord-306904-8iteddug	710	3	here	here	RB
cord-306904-8iteddug	710	4	is	be	VBZ
cord-306904-8iteddug	710	5	in	in	IN
cord-306904-8iteddug	710	6	the	the	DT
cord-306904-8iteddug	710	7	fact	fact	NN
cord-306904-8iteddug	710	8	that	that	IN
cord-306904-8iteddug	710	9	htRNA	htrna	NN
cord-306904-8iteddug	711	1	Lys3	Lys3	NNP
cord-306904-8iteddug	711	2	UUU	UUU	NNP
cord-306904-8iteddug	711	3	is	be	VBZ
cord-306904-8iteddug	711	4	one	one	CD
cord-306904-8iteddug	711	5	of	of	IN
cord-306904-8iteddug	711	6	the	the	DT
cord-306904-8iteddug	711	7	most	most	RBS
cord-306904-8iteddug	711	8	uniquely	uniquely	RB
cord-306904-8iteddug	711	9	processed	process	VBN
cord-306904-8iteddug	711	10	tRNAs	trna	NNS
cord-306904-8iteddug	711	11	that	that	WDT
cord-306904-8iteddug	711	12	has	have	VBZ
cord-306904-8iteddug	711	13	a	a	DT
cord-306904-8iteddug	711	14	broad	broad	JJ
cord-306904-8iteddug	711	15	spectrum	spectrum	NN
cord-306904-8iteddug	711	16	of	of	IN
cord-306904-8iteddug	711	17	chemically	chemically	RB
cord-306904-8iteddug	711	18	different	different	JJ
cord-306904-8iteddug	711	19	post	post	JJ
cord-306904-8iteddug	711	20	-	-	JJ
cord-306904-8iteddug	711	21	transcriptional	transcriptional	JJ
cord-306904-8iteddug	711	22	modifications	modification	NNS
cord-306904-8iteddug	711	23	playing	play	VBG
cord-306904-8iteddug	711	24	crucial	crucial	JJ
cord-306904-8iteddug	711	25	roles	role	NNS
cord-306904-8iteddug	711	26	in	in	IN
cord-306904-8iteddug	711	27	regulation	regulation	NN
cord-306904-8iteddug	711	28	of	of	IN
cord-306904-8iteddug	711	29	the	the	DT
cord-306904-8iteddug	711	30	conformation	conformation	NN
cord-306904-8iteddug	711	31	and	and	CC
cord-306904-8iteddug	711	32	function	function	NN
cord-306904-8iteddug	711	33	of	of	IN
cord-306904-8iteddug	711	34	this	this	DT
cord-306904-8iteddug	711	35	tRNA	trna	NN
cord-306904-8iteddug	711	36	during	during	IN
cord-306904-8iteddug	711	37	protein	protein	NN
cord-306904-8iteddug	711	38	synthesis	synthesis	NN
cord-306904-8iteddug	711	39	.	.	.
cord-306904-8iteddug	712	1	252	252	CD
cord-306904-8iteddug	713	1	Using	use	VBG
cord-306904-8iteddug	713	2	phage	phage	NN
cord-306904-8iteddug	713	3	display	display	NN
cord-306904-8iteddug	713	4	approach	approach	NN
cord-306904-8iteddug	713	5	,	,	,
cord-306904-8iteddug	713	6	Spears	Spears	NNP
cord-306904-8iteddug	713	7	et	et	NNP
cord-306904-8iteddug	713	8	al	al	NNP
cord-306904-8iteddug	713	9	.	.	NNP
cord-306904-8iteddug	713	10	showed	show	VBD
cord-306904-8iteddug	713	11	that	that	IN
cord-306904-8iteddug	713	12	p7	p7	DT
cord-306904-8iteddug	713	13	contains	contain	VBZ
cord-306904-8iteddug	713	14	a	a	DT
cord-306904-8iteddug	713	15	specific	specific	JJ
cord-306904-8iteddug	713	16	htRNA	htrna	NN
cord-306904-8iteddug	713	17	-	-	:
cord-306904-8iteddug	713	18	Lys3	Lys3	NNP
cord-306904-8iteddug	713	19	UUU	UUU	NNP
cord-306904-8iteddug	713	20	-binding	-binding	NNP
cord-306904-8iteddug	713	21	region	region	NN
cord-306904-8iteddug	713	22	whose	whose	WP$
cord-306904-8iteddug	713	23	interaction	interaction	NN
cord-306904-8iteddug	713	24	with	with	IN
cord-306904-8iteddug	713	25	fully	fully	RB
cord-306904-8iteddug	713	26	modified	modify	VBN
cord-306904-8iteddug	713	27	tRNA	trna	NN
cord-306904-8iteddug	713	28	can	can	MD
cord-306904-8iteddug	713	29	be	be	VB
cord-306904-8iteddug	713	30	mimicked	mimic	VBN
cord-306904-8iteddug	713	31	by	by	IN
cord-306904-8iteddug	713	32	the	the	DT
cord-306904-8iteddug	713	33	15-and	15-and	CD
cord-306904-8iteddug	713	34	16-amino	16-amino	CD
cord-306904-8iteddug	713	35	acid	acid	NN
cord-306904-8iteddug	713	36	peptides	peptide	NNS
cord-306904-8iteddug	713	37	with	with	IN
cord-306904-8iteddug	713	38	the	the	DT
cord-306904-8iteddug	713	39	signature	signature	NN
cord-306904-8iteddug	713	40	sequence	sequence	NN
cord-306904-8iteddug	713	41	of	of	IN
cord-306904-8iteddug	713	42	R	R	NNP
cord-306904-8iteddug	713	43	-	-	HYPH
cord-306904-8iteddug	713	44	W	W	NNP
cord-306904-8iteddug	713	45	-	-	HYPH
cord-306904-8iteddug	713	46	Q	Q	NNP
cord-306904-8iteddug	713	47	/	/	SYM
cord-306904-8iteddug	713	48	N	N	NNP
cord-306904-8iteddug	713	49	-	-	HYPH
cord-306904-8iteddug	713	50	H	H	NNP
cord-306904-8iteddug	713	51	-	-	HYPH
cord-306904-8iteddug	713	52	X	x	NN
cord-306904-8iteddug	713	53	2	2	CD
cord-306904-8iteddug	713	54	-F	-f	ADD
cord-306904-8iteddug	713	55	-	-	HYPH
cord-306904-8iteddug	713	56	Pho	Pho	NNP
cord-306904-8iteddug	713	57	-	-	HYPH
cord-306904-8iteddug	713	58	X	x	NN
cord-306904-8iteddug	713	59	-	-	HYPH
cord-306904-8iteddug	713	60	G	G	NNP
cord-306904-8iteddug	713	61	/	/	SYM
cord-306904-8iteddug	713	62	A	A	NNP
cord-306904-8iteddug	713	63	-	-	HYPH
cord-306904-8iteddug	713	64	W	w	NN
cord-306904-8iteddug	713	65	-	-	HYPH
cord-306904-8iteddug	713	66	R	r	NN
cord-306904-8iteddug	713	67	-	-	HYPH
cord-306904-8iteddug	713	68	X	x	NN
cord-306904-8iteddug	713	69	2	2	CD
cord-306904-8iteddug	714	1	-G	-G	.
cord-306904-8iteddug	715	1	(	(	-LRB-
cord-306904-8iteddug	715	2	where	where	WRB
cord-306904-8iteddug	715	3	X	x	NN
cord-306904-8iteddug	715	4	can	can	MD
cord-306904-8iteddug	715	5	be	be	VB
cord-306904-8iteddug	715	6	most	most	JJS
cord-306904-8iteddug	715	7	amino	amino	JJ
cord-306904-8iteddug	715	8	acids	acid	NNS
cord-306904-8iteddug	715	9	,	,	,
cord-306904-8iteddug	715	10	and	and	CC
cord-306904-8iteddug	715	11	Pho	Pho	NNP
cord-306904-8iteddug	715	12	is	be	VBZ
cord-306904-8iteddug	715	13	any	any	DT
cord-306904-8iteddug	715	14	hydrophobic	hydrophobic	JJ
cord-306904-8iteddug	715	15	residue	residue	NN
cord-306904-8iteddug	715	16	)	)	-RRB-
cord-306904-8iteddug	715	17	.	.	.
cord-306904-8iteddug	716	1	251	251	CD
cord-306904-8iteddug	716	2	HIV-1	HIV-1	NNP
cord-306904-8iteddug	716	3	nucleocapsid	nucleocapsid	NN
cord-306904-8iteddug	716	4	protein	protein	NN
cord-306904-8iteddug	716	5	p7	p7	RB
cord-306904-8iteddug	716	6	is	be	VBZ
cord-306904-8iteddug	716	7	a	a	DT
cord-306904-8iteddug	716	8	55residues	55residues	CD
cord-306904-8iteddug	716	9	-	-	HYPH
cord-306904-8iteddug	716	10	long	long	JJ
cord-306904-8iteddug	716	11	protein	protein	NN
cord-306904-8iteddug	716	12	containing	contain	VBG
cord-306904-8iteddug	716	13	2	2	CD
cord-306904-8iteddug	716	14	zinc	zinc	NN
cord-306904-8iteddug	716	15	finger	finger	NN
cord-306904-8iteddug	716	16	domains	domain	NNS
cord-306904-8iteddug	716	17	flanked	flank	VBN
cord-306904-8iteddug	716	18	by	by	IN
cord-306904-8iteddug	716	19	basic	basic	JJ
cord-306904-8iteddug	716	20	amino	amino	NN
cord-306904-8iteddug	716	21	acids	acid	NNS
cord-306904-8iteddug	716	22	required	require	VBN
cord-306904-8iteddug	716	23	for	for	IN
cord-306904-8iteddug	716	24	interaction	interaction	NN
cord-306904-8iteddug	716	25	with	with	IN
cord-306904-8iteddug	716	26	nucleic	nucleic	JJ
cord-306904-8iteddug	716	27	acids	acid	NNS
cord-306904-8iteddug	716	28	.	.	.
cord-306904-8iteddug	717	1	253	253	CD
cord-306904-8iteddug	717	2	,	,	,
cord-306904-8iteddug	717	3	254	254	CD
cord-306904-8iteddug	718	1	In	in	IN
cord-306904-8iteddug	718	2	addition	addition	NN
cord-306904-8iteddug	718	3	to	to	IN
cord-306904-8iteddug	718	4	the	the	DT
cord-306904-8iteddug	718	5	discussed	discuss	VBN
cord-306904-8iteddug	718	6	above	above	IN
cord-306904-8iteddug	718	7	capability	capability	NN
cord-306904-8iteddug	718	8	of	of	IN
cord-306904-8iteddug	718	9	p7	p7	NN
cord-306904-8iteddug	718	10	to	to	TO
cord-306904-8iteddug	718	11	specifically	specifically	RB
cord-306904-8iteddug	718	12	recognize	recognize	VB
cord-306904-8iteddug	718	13	htRNA	htRNA	NNS
cord-306904-8iteddug	719	1	Lys3	Lys3	NNP
cord-306904-8iteddug	719	2	UUU	UUU	NNP
cord-306904-8iteddug	719	3	,	,	,
cord-306904-8iteddug	719	4	the	the	DT
cord-306904-8iteddug	719	5	major	major	JJ
cord-306904-8iteddug	719	6	function	function	NN
cord-306904-8iteddug	719	7	of	of	IN
cord-306904-8iteddug	719	8	p7	p7	NN
cord-306904-8iteddug	719	9	is	be	VBZ
cord-306904-8iteddug	719	10	to	to	TO
cord-306904-8iteddug	719	11	bind	bind	VB
cord-306904-8iteddug	719	12	specifically	specifically	RB
cord-306904-8iteddug	719	13	to	to	IN
cord-306904-8iteddug	719	14	the	the	DT
cord-306904-8iteddug	719	15	packaging	packaging	NN
cord-306904-8iteddug	719	16	signal	signal	NN
cord-306904-8iteddug	719	17	of	of	IN
cord-306904-8iteddug	719	18	the	the	DT
cord-306904-8iteddug	719	19	full	full	JJ
cord-306904-8iteddug	719	20	-	-	HYPH
cord-306904-8iteddug	719	21	length	length	NN
cord-306904-8iteddug	719	22	viral	viral	JJ
cord-306904-8iteddug	719	23	RNAs	rna	NNS
cord-306904-8iteddug	719	24	and	and	CC
cord-306904-8iteddug	719	25	to	to	TO
cord-306904-8iteddug	719	26	deliver	deliver	VB
cord-306904-8iteddug	719	27	them	-PRON-	PRP
cord-306904-8iteddug	719	28	into	into	IN
cord-306904-8iteddug	719	29	the	the	DT
cord-306904-8iteddug	719	30	assembling	assemble	VBG
cord-306904-8iteddug	719	31	virion	virion	NN
cord-306904-8iteddug	719	32	.	.	.
cord-306904-8iteddug	720	1	255	255	CD
cord-306904-8iteddug	721	1	As	as	IN
cord-306904-8iteddug	721	2	it	-PRON-	PRP
cord-306904-8iteddug	721	3	is	be	VBZ
cord-306904-8iteddug	721	4	a	a	DT
cord-306904-8iteddug	721	5	highly	highly	RB
cord-306904-8iteddug	721	6	charged	charge	VBN
cord-306904-8iteddug	721	7	basic	basic	JJ
cord-306904-8iteddug	721	8	protein	protein	NN
cord-306904-8iteddug	721	9	,	,	,
cord-306904-8iteddug	721	10	p7	p7	NN
cord-306904-8iteddug	721	11	binds	bind	VBZ
cord-306904-8iteddug	721	12	single	single	RB
cord-306904-8iteddug	721	13	-	-	HYPH
cord-306904-8iteddug	721	14	stranded	strand	VBN
cord-306904-8iteddug	721	15	nucleic	nucleic	JJ
cord-306904-8iteddug	721	16	acids	acid	NNS
cord-306904-8iteddug	721	17	nonspecifically	nonspecifically	RB
cord-306904-8iteddug	721	18	.	.	.
cord-306904-8iteddug	722	1	Consequently	consequently	RB
cord-306904-8iteddug	722	2	,	,	,
cord-306904-8iteddug	722	3	it	-PRON-	PRP
cord-306904-8iteddug	722	4	coats	coat	VBZ
cord-306904-8iteddug	722	5	the	the	DT
cord-306904-8iteddug	722	6	genomic	genomic	JJ
cord-306904-8iteddug	722	7	RNA	rna	NN
cord-306904-8iteddug	722	8	protecting	protect	VBG
cord-306904-8iteddug	722	9	it	-PRON-	PRP
cord-306904-8iteddug	722	10	from	from	IN
cord-306904-8iteddug	722	11	nucleases	nuclease	NNS
cord-306904-8iteddug	722	12	and	and	CC
cord-306904-8iteddug	722	13	compacting	compact	VBG
cord-306904-8iteddug	722	14	viral	viral	JJ
cord-306904-8iteddug	722	15	RNA	rna	NN
cord-306904-8iteddug	722	16	within	within	IN
cord-306904-8iteddug	722	17	the	the	DT
cord-306904-8iteddug	722	18	core	core	NN
cord-306904-8iteddug	722	19	.	.	.
cord-306904-8iteddug	723	1	Protein	protein	NN
cord-306904-8iteddug	723	2	p7	p7	RB
cord-306904-8iteddug	723	3	also	also	RB
cord-306904-8iteddug	723	4	serves	serve	VBZ
cord-306904-8iteddug	723	5	as	as	IN
cord-306904-8iteddug	723	6	an	an	DT
cord-306904-8iteddug	723	7	RNA	RNA	NNP
cord-306904-8iteddug	723	8	chaperone	chaperone	NN
cord-306904-8iteddug	723	9	that	that	WDT
cord-306904-8iteddug	723	10	enhances	enhance	VBZ
cord-306904-8iteddug	723	11	several	several	JJ
cord-306904-8iteddug	723	12	nucleic	nucleic	JJ
cord-306904-8iteddug	723	13	acid	acid	NN
cord-306904-8iteddug	723	14	-	-	HYPH
cord-306904-8iteddug	723	15	dependent	dependent	JJ
cord-306904-8iteddug	723	16	steps	step	NNS
cord-306904-8iteddug	723	17	of	of	IN
cord-306904-8iteddug	723	18	viral	viral	JJ
cord-306904-8iteddug	723	19	life	life	NN
cord-306904-8iteddug	723	20	,	,	,
cord-306904-8iteddug	723	21	such	such	JJ
cord-306904-8iteddug	723	22	as	as	IN
cord-306904-8iteddug	723	23	melting	melt	VBG
cord-306904-8iteddug	723	24	RNA	RNA	NNP
cord-306904-8iteddug	723	25	secondary	secondary	JJ
cord-306904-8iteddug	723	26	structures	structure	NNS
cord-306904-8iteddug	723	27	,	,	,
cord-306904-8iteddug	723	28	promoting	promote	VBG
cord-306904-8iteddug	723	29	DNA	dna	NN
cord-306904-8iteddug	723	30	strand	strand	NN
cord-306904-8iteddug	723	31	exchange	exchange	NN
cord-306904-8iteddug	723	32	reactions	reaction	NNS
cord-306904-8iteddug	723	33	during	during	IN
cord-306904-8iteddug	723	34	reverse	reverse	JJ
cord-306904-8iteddug	723	35	transcription	transcription	NN
cord-306904-8iteddug	723	36	,	,	,
cord-306904-8iteddug	723	37	[	[	-LRB-
cord-306904-8iteddug	723	38	256	256	CD
cord-306904-8iteddug	723	39	]	]	-RRB-
cord-306904-8iteddug	723	40	[	[	-LRB-
cord-306904-8iteddug	723	41	257	257	CD
cord-306904-8iteddug	723	42	]	]	-RRB-
cord-306904-8iteddug	723	43	[	[	-LRB-
cord-306904-8iteddug	723	44	258	258	CD
cord-306904-8iteddug	723	45	]	]	-RRB-
cord-306904-8iteddug	723	46	and	and	CC
cord-306904-8iteddug	723	47	stimulating	stimulate	VBG
cord-306904-8iteddug	723	48	integration	integration	NN
cord-306904-8iteddug	723	49	.	.	.
cord-306904-8iteddug	724	1	259	259	CD
cord-306904-8iteddug	725	1	In	in	IN
cord-306904-8iteddug	725	2	the	the	DT
cord-306904-8iteddug	725	3	NMR	NMR	NNP
cord-306904-8iteddug	725	4	solution	solution	NN
cord-306904-8iteddug	725	5	structure	structure	NN
cord-306904-8iteddug	725	6	of	of	IN
cord-306904-8iteddug	725	7	p7	p7	NN
cord-306904-8iteddug	725	8	,	,	,
cord-306904-8iteddug	725	9	regions	region	NNS
cord-306904-8iteddug	725	10	corresponding	correspond	VBG
cord-306904-8iteddug	725	11	to	to	IN
cord-306904-8iteddug	725	12	the	the	DT
cord-306904-8iteddug	725	13	2	2	CD
cord-306904-8iteddug	725	14	zinc	zinc	NN
cord-306904-8iteddug	725	15	fingers	finger	NNS
cord-306904-8iteddug	725	16	(	(	-LRB-
cord-306904-8iteddug	725	17	residues	residue	NNS
cord-306904-8iteddug	725	18	15	15	CD
cord-306904-8iteddug	725	19	-	-	SYM
cord-306904-8iteddug	725	20	28	28	CD
cord-306904-8iteddug	725	21	and	and	CC
cord-306904-8iteddug	725	22	36	36	CD
cord-306904-8iteddug	725	23	-	-	SYM
cord-306904-8iteddug	725	24	49	49	CD
cord-306904-8iteddug	725	25	)	)	-RRB-
cord-306904-8iteddug	725	26	possess	possess	VBP
cord-306904-8iteddug	725	27	wellresolved	wellresolved	JJ
cord-306904-8iteddug	725	28	structures	structure	NNS
cord-306904-8iteddug	725	29	,	,	,
cord-306904-8iteddug	725	30	whereas	whereas	IN
cord-306904-8iteddug	725	31	residues	residue	NNS
cord-306904-8iteddug	725	32	1	1	CD
cord-306904-8iteddug	725	33	-	-	SYM
cord-306904-8iteddug	725	34	13	13	CD
cord-306904-8iteddug	725	35	,	,	,
cord-306904-8iteddug	725	36	32	32	CD
cord-306904-8iteddug	725	37	-	-	SYM
cord-306904-8iteddug	725	38	34	34	CD
cord-306904-8iteddug	725	39	,	,	,
cord-306904-8iteddug	725	40	and	and	CC
cord-306904-8iteddug	725	41	52	52	CD
cord-306904-8iteddug	725	42	-	-	SYM
cord-306904-8iteddug	725	43	55	55	CD
cord-306904-8iteddug	725	44	were	be	VBD
cord-306904-8iteddug	725	45	highly	highly	RB
cord-306904-8iteddug	725	46	dynamic	dynamic	JJ
cord-306904-8iteddug	725	47	and	and	CC
cord-306904-8iteddug	725	48	did	do	VBD
cord-306904-8iteddug	725	49	not	not	RB
cord-306904-8iteddug	725	50	converge	converge	VB
cord-306904-8iteddug	725	51	to	to	IN
cord-306904-8iteddug	725	52	the	the	DT
cord-306904-8iteddug	725	53	unique	unique	JJ
cord-306904-8iteddug	725	54	conformations	conformation	NNS
cord-306904-8iteddug	725	55	.	.	.
cord-306904-8iteddug	726	1	260	260	CD
cord-306904-8iteddug	726	2	,	,	,
cord-306904-8iteddug	726	3	261	261	CD
cord-306904-8iteddug	726	4	Recent	recent	JJ
cord-306904-8iteddug	726	5	intrinsic	intrinsic	JJ
cord-306904-8iteddug	726	6	disorder	disorder	NN
cord-306904-8iteddug	726	7	propensity	propensity	NN
cord-306904-8iteddug	726	8	analysis	analysis	NN
cord-306904-8iteddug	726	9	revealed	reveal	VBD
cord-306904-8iteddug	726	10	that	that	IN
cord-306904-8iteddug	726	11	p7	p7	NN
cord-306904-8iteddug	726	12	is	be	VBZ
cord-306904-8iteddug	726	13	a	a	DT
cord-306904-8iteddug	726	14	highly	highly	RB
cord-306904-8iteddug	726	15	disordered	disordered	JJ
cord-306904-8iteddug	726	16	protein	protein	NN
cord-306904-8iteddug	726	17	,	,	,
cord-306904-8iteddug	726	18	with	with	IN
cord-306904-8iteddug	726	19	regions	region	NNS
cord-306904-8iteddug	726	20	corresponding	correspond	VBG
cord-306904-8iteddug	726	21	to	to	IN
cord-306904-8iteddug	726	22	the	the	DT
cord-306904-8iteddug	726	23	zinc	zinc	NN
cord-306904-8iteddug	726	24	fingers	finger	NNS
cord-306904-8iteddug	726	25	predicted	predict	VBD
cord-306904-8iteddug	726	26	to	to	TO
cord-306904-8iteddug	726	27	be	be	VB
cord-306904-8iteddug	726	28	more	more	RBR
cord-306904-8iteddug	726	29	ordered	order	VBN
cord-306904-8iteddug	726	30	than	than	IN
cord-306904-8iteddug	726	31	the	the	DT
cord-306904-8iteddug	726	32	remainder	remainder	NN
cord-306904-8iteddug	726	33	of	of	IN
cord-306904-8iteddug	726	34	the	the	DT
cord-306904-8iteddug	726	35	protein	protein	NN
cord-306904-8iteddug	726	36	and	and	CC
cord-306904-8iteddug	726	37	identified	identify	VBD
cord-306904-8iteddug	726	38	as	as	IN
cord-306904-8iteddug	726	39	potential	potential	JJ
cord-306904-8iteddug	726	40	a	a	DT
cord-306904-8iteddug	726	41	-	-	HYPH
cord-306904-8iteddug	726	42	MoRFs	morfs	NN
cord-306904-8iteddug	726	43	.	.	.
cord-306904-8iteddug	727	1	262	262	CD
cord-306904-8iteddug	728	1	This	this	DT
cord-306904-8iteddug	728	2	article	article	NN
cord-306904-8iteddug	728	3	represents	represent	VBZ
cord-306904-8iteddug	728	4	a	a	DT
cord-306904-8iteddug	728	5	set	set	NN
cord-306904-8iteddug	728	6	of	of	IN
cord-306904-8iteddug	728	7	papers	paper	NNS
cord-306904-8iteddug	728	8	dealing	deal	VBG
cord-306904-8iteddug	728	9	with	with	IN
cord-306904-8iteddug	728	10	interesting	interesting	JJ
cord-306904-8iteddug	728	11	and	and	CC
cord-306904-8iteddug	728	12	important	important	JJ
cord-306904-8iteddug	728	13	proteins	protein	NNS
cord-306904-8iteddug	728	14	with	with	IN
cord-306904-8iteddug	728	15	diverse	diverse	JJ
cord-306904-8iteddug	728	16	functions	function	NNS
cord-306904-8iteddug	728	17	from	from	IN
cord-306904-8iteddug	728	18	various	various	JJ
cord-306904-8iteddug	728	19	organisms	organism	NNS
cord-306904-8iteddug	728	20	.	.	.
cord-306904-8iteddug	729	1	The	the	DT
cord-306904-8iteddug	729	2	only	only	JJ
cord-306904-8iteddug	729	3	uniting	unite	VBG
cord-306904-8iteddug	729	4	theme	theme	NN
cord-306904-8iteddug	729	5	for	for	IN
cord-306904-8iteddug	729	6	all	all	PDT
cord-306904-8iteddug	729	7	these	these	DT
cord-306904-8iteddug	729	8	studies	study	NNS
cord-306904-8iteddug	729	9	is	be	VBZ
cord-306904-8iteddug	729	10	the	the	DT
cord-306904-8iteddug	729	11	notion	notion	NN
cord-306904-8iteddug	729	12	that	that	IN
cord-306904-8iteddug	729	13	they	-PRON-	PRP
cord-306904-8iteddug	729	14	represent	represent	VBP
cord-306904-8iteddug	729	15	noticeable	noticeable	JJ
cord-306904-8iteddug	729	16	disorder	disorder	NN
cord-306904-8iteddug	729	17	overlooks	overlook	VBZ
cord-306904-8iteddug	729	18	.	.	.
cord-306904-8iteddug	730	1	In	in	IN
cord-306904-8iteddug	730	2	fact	fact	NN
cord-306904-8iteddug	730	3	,	,	,
cord-306904-8iteddug	730	4	all	all	DT
cord-306904-8iteddug	730	5	proteins	protein	NNS
cord-306904-8iteddug	730	6	studied	study	VBD
cord-306904-8iteddug	730	7	there	there	RB
cord-306904-8iteddug	730	8	contain	contain	VBP
cord-306904-8iteddug	730	9	intrinsic	intrinsic	JJ
cord-306904-8iteddug	730	10	disorder	disorder	NN
cord-306904-8iteddug	730	11	.	.	.
cord-306904-8iteddug	731	1	The	the	DT
cord-306904-8iteddug	731	2	amount	amount	NN
cord-306904-8iteddug	731	3	of	of	IN
cord-306904-8iteddug	731	4	disorder	disorder	NN
cord-306904-8iteddug	731	5	ranges	range	NNS
cord-306904-8iteddug	731	6	,	,	,
cord-306904-8iteddug	731	7	and	and	CC
cord-306904-8iteddug	731	8	in	in	IN
cord-306904-8iteddug	731	9	some	some	DT
cord-306904-8iteddug	731	10	proteins	protein	NNS
cord-306904-8iteddug	731	11	only	only	RB
cord-306904-8iteddug	731	12	relative	relative	JJ
cord-306904-8iteddug	731	13	short	short	JJ
cord-306904-8iteddug	731	14	regions	region	NNS
cord-306904-8iteddug	731	15	are	be	VBP
cord-306904-8iteddug	731	16	disordered	disordered	JJ
cord-306904-8iteddug	731	17	or	or	CC
cord-306904-8iteddug	731	18	highly	highly	RB
cord-306904-8iteddug	731	19	flexible	flexible	JJ
cord-306904-8iteddug	731	20	,	,	,
cord-306904-8iteddug	731	21	whereas	whereas	IN
cord-306904-8iteddug	731	22	some	some	DT
cord-306904-8iteddug	731	23	other	other	JJ
cord-306904-8iteddug	731	24	proteins	protein	NNS
cord-306904-8iteddug	731	25	are	be	VBP
cord-306904-8iteddug	731	26	almost	almost	RB
cord-306904-8iteddug	731	27	entirely	entirely	RB
cord-306904-8iteddug	731	28	disordered	disordered	JJ
cord-306904-8iteddug	731	29	.	.	.
cord-306904-8iteddug	732	1	However	however	RB
cord-306904-8iteddug	732	2	,	,	,
cord-306904-8iteddug	732	3	very	very	RB
cord-306904-8iteddug	732	4	often	often	RB
cord-306904-8iteddug	732	5	this	this	DT
cord-306904-8iteddug	732	6	disorder	disorder	NN
cord-306904-8iteddug	732	7	has	have	VBZ
cord-306904-8iteddug	732	8	functional	functional	JJ
cord-306904-8iteddug	732	9	implementations	implementation	NNS
cord-306904-8iteddug	732	10	,	,	,
cord-306904-8iteddug	732	11	and	and	CC
cord-306904-8iteddug	732	12	consideration	consideration	NN
cord-306904-8iteddug	732	13	of	of	IN
cord-306904-8iteddug	732	14	studied	study	VBN
cord-306904-8iteddug	732	15	proteins	protein	NNS
cord-306904-8iteddug	732	16	in	in	IN
cord-306904-8iteddug	732	17	light	light	NN
cord-306904-8iteddug	732	18	of	of	IN
cord-306904-8iteddug	732	19	intrinsic	intrinsic	JJ
cord-306904-8iteddug	732	20	disorder	disorder	NN
cord-306904-8iteddug	732	21	often	often	RB
cord-306904-8iteddug	732	22	provides	provide	VBZ
cord-306904-8iteddug	732	23	interesting	interesting	JJ
cord-306904-8iteddug	732	24	mechanical	mechanical	JJ
cord-306904-8iteddug	732	25	clues	clue	NNS
cord-306904-8iteddug	732	26	on	on	IN
cord-306904-8iteddug	732	27	the	the	DT
cord-306904-8iteddug	732	28	molecular	molecular	JJ
cord-306904-8iteddug	732	29	mechanisms	mechanism	NNS
cord-306904-8iteddug	732	30	of	of	IN
cord-306904-8iteddug	732	31	their	-PRON-	PRP$
cord-306904-8iteddug	732	32	action	action	NN
cord-306904-8iteddug	732	33	.	.	.
cord-306904-8iteddug	733	1	We	-PRON-	PRP
cord-306904-8iteddug	733	2	hope	hope	VBP
cord-306904-8iteddug	733	3	that	that	IN
cord-306904-8iteddug	733	4	the	the	DT
cord-306904-8iteddug	733	5	readers	reader	NNS
cord-306904-8iteddug	733	6	will	will	MD
cord-306904-8iteddug	733	7	find	find	VB
cord-306904-8iteddug	733	8	this	this	DT
cord-306904-8iteddug	733	9	new	new	JJ
cord-306904-8iteddug	733	10	series	series	NN
cord-306904-8iteddug	733	11	useful	useful	JJ
cord-306904-8iteddug	733	12	,	,	,
cord-306904-8iteddug	733	13	since	since	IN
cord-306904-8iteddug	733	14	it	-PRON-	PRP
cord-306904-8iteddug	733	15	might	may	MD
cord-306904-8iteddug	733	16	increase	increase	VB
cord-306904-8iteddug	733	17	the	the	DT
cord-306904-8iteddug	733	18	awareness	awareness	NN
cord-306904-8iteddug	733	19	of	of	IN
cord-306904-8iteddug	733	20	the	the	DT
cord-306904-8iteddug	733	21	scientific	scientific	JJ
cord-306904-8iteddug	733	22	community	community	NN
cord-306904-8iteddug	733	23	about	about	IN
cord-306904-8iteddug	733	24	importance	importance	NN
cord-306904-8iteddug	733	25	of	of	IN
cord-306904-8iteddug	733	26	intrinsic	intrinsic	JJ
cord-306904-8iteddug	733	27	disorder	disorder	NN
cord-306904-8iteddug	733	28	for	for	IN
cord-306904-8iteddug	733	29	protein	protein	NN
cord-306904-8iteddug	733	30	function	function	NN
cord-306904-8iteddug	733	31	.	.	.
cord-306904-8iteddug	734	1	We	-PRON-	PRP
cord-306904-8iteddug	734	2	also	also	RB
cord-306904-8iteddug	734	3	hope	hope	VBP
cord-306904-8iteddug	734	4	to	to	TO
cord-306904-8iteddug	734	5	see	see	VB
cord-306904-8iteddug	734	6	submissions	submission	NNS
cord-306904-8iteddug	734	7	from	from	IN
cord-306904-8iteddug	734	8	readers	reader	NNS
cord-306904-8iteddug	734	9	who	who	WP
cord-306904-8iteddug	734	10	found	find	VBD
cord-306904-8iteddug	734	11	some	some	DT
cord-306904-8iteddug	734	12	important	important	JJ
cord-306904-8iteddug	734	13	intrinsic	intrinsic	JJ
cord-306904-8iteddug	734	14	disorder	disorder	NN
cord-306904-8iteddug	734	15	overlooks	overlook	VBZ
cord-306904-8iteddug	734	16	in	in	IN
cord-306904-8iteddug	734	17	published	publish	VBN
cord-306904-8iteddug	734	18	articles	article	NNS
cord-306904-8iteddug	734	19	.	.	.
cord-306904-8iteddug	735	1	Obviously	obviously	RB
cord-306904-8iteddug	735	2	,	,	,
cord-306904-8iteddug	735	3	papers	paper	NNS
cord-306904-8iteddug	735	4	in	in	IN
cord-306904-8iteddug	735	5	this	this	DT
cord-306904-8iteddug	735	6	seris	seris	NNP
cord-306904-8iteddug	735	7	will	will	MD
cord-306904-8iteddug	735	8	range	range	VB
cord-306904-8iteddug	735	9	in	in	IN
cord-306904-8iteddug	735	10	their	-PRON-	PRP$
cord-306904-8iteddug	735	11	size	size	NN
cord-306904-8iteddug	735	12	,	,	,
cord-306904-8iteddug	735	13	and	and	CC
cord-306904-8iteddug	735	14	we	-PRON-	PRP
cord-306904-8iteddug	735	15	envision	envision	VBP
cord-306904-8iteddug	735	16	several	several	JJ
cord-306904-8iteddug	735	17	types	type	NNS
cord-306904-8iteddug	735	18	of	of	IN
cord-306904-8iteddug	735	19	submissions	submission	NNS
cord-306904-8iteddug	735	20	,	,	,
cord-306904-8iteddug	735	21	such	such	JJ
cord-306904-8iteddug	735	22	as	as	IN
cord-306904-8iteddug	735	23	comprehensive	comprehensive	JJ
cord-306904-8iteddug	735	24	reviews	review	NNS
cord-306904-8iteddug	735	25	of	of	IN
cord-306904-8iteddug	735	26	unreported	unreported	JJ
cord-306904-8iteddug	735	27	disorder	disorder	NN
cord-306904-8iteddug	735	28	in	in	IN
cord-306904-8iteddug	735	29	papers	paper	NNS
cord-306904-8iteddug	735	30	published	publish	VBN
cord-306904-8iteddug	735	31	in	in	IN
cord-306904-8iteddug	735	32	particular	particular	JJ
cord-306904-8iteddug	735	33	journals	journal	NNS
cord-306904-8iteddug	735	34	(	(	-LRB-
cord-306904-8iteddug	735	35	i.e.	i.e.	FW
cord-306904-8iteddug	735	36	,	,	,
cord-306904-8iteddug	735	37	similar	similar	JJ
cord-306904-8iteddug	735	38	to	to	IN
cord-306904-8iteddug	735	39	this	this	DT
cord-306904-8iteddug	735	40	review	review	NN
cord-306904-8iteddug	735	41	)	)	-RRB-
cord-306904-8iteddug	735	42	,	,	,
cord-306904-8iteddug	735	43	reviews	review	NNS
cord-306904-8iteddug	735	44	of	of	IN
cord-306904-8iteddug	735	45	unreported	unreported	JJ
cord-306904-8iteddug	735	46	disorder	disorder	NN
cord-306904-8iteddug	735	47	in	in	IN
cord-306904-8iteddug	735	48	specific	specific	JJ
cord-306904-8iteddug	735	49	areas	area	NNS
cord-306904-8iteddug	735	50	of	of	IN
cord-306904-8iteddug	735	51	protein	protein	NN
cord-306904-8iteddug	735	52	-	-	HYPH
cord-306904-8iteddug	735	53	related	relate	VBN
cord-306904-8iteddug	735	54	research	research	NN
cord-306904-8iteddug	735	55	,	,	,
cord-306904-8iteddug	735	56	as	as	RB
cord-306904-8iteddug	735	57	well	well	RB
cord-306904-8iteddug	735	58	as	as	IN
cord-306904-8iteddug	735	59	brief	brief	JJ
cord-306904-8iteddug	735	60	notes	note	NNS
cord-306904-8iteddug	735	61	about	about	IN
cord-306904-8iteddug	735	62	overlooked	overlooked	JJ
cord-306904-8iteddug	735	63	disorder	disorder	NN
cord-306904-8iteddug	735	64	in	in	IN
cord-306904-8iteddug	735	65	individual	individual	JJ
cord-306904-8iteddug	735	66	papers	paper	NNS
cord-306904-8iteddug	735	67	.	.	.
cord-306904-8iteddug	736	1	The	the	DT
cord-306904-8iteddug	736	2	biggest	big	JJS
cord-306904-8iteddug	736	3	hope	hope	NN
cord-306904-8iteddug	736	4	though	though	RB
cord-306904-8iteddug	736	5	is	be	VBZ
cord-306904-8iteddug	736	6	that	that	IN
cord-306904-8iteddug	736	7	this	this	DT
cord-306904-8iteddug	736	8	series	series	NN
cord-306904-8iteddug	736	9	will	will	MD
cord-306904-8iteddug	736	10	become	become	VB
cord-306904-8iteddug	736	11	obsolete	obsolete	JJ
cord-306904-8iteddug	736	12	,	,	,
cord-306904-8iteddug	736	13	and	and	CC
cord-306904-8iteddug	736	14	protein	protein	NN
cord-306904-8iteddug	736	15	intrinsic	intrinsic	JJ
cord-306904-8iteddug	736	16	disorder	disorder	NN
cord-306904-8iteddug	736	17	will	will	MD
cord-306904-8iteddug	736	18	find	find	VB
cord-306904-8iteddug	736	19	its	-PRON-	PRP$
cord-306904-8iteddug	736	20	way	way	NN
cord-306904-8iteddug	736	21	to	to	TO
cord-306904-8iteddug	736	22	be	be	VB
cord-306904-8iteddug	736	23	robustly	robustly	RB
cord-306904-8iteddug	736	24	present	present	JJ
cord-306904-8iteddug	736	25	in	in	IN
cord-306904-8iteddug	736	26	the	the	DT
cord-306904-8iteddug	736	27	scientific	scientific	JJ
cord-306904-8iteddug	736	28	literature	literature	NN
cord-306904-8iteddug	736	29	.	.	.
cord-306904-8iteddug	737	1	No	no	DT
cord-306904-8iteddug	737	2	potential	potential	JJ
cord-306904-8iteddug	737	3	conflicts	conflict	NNS
cord-306904-8iteddug	737	4	of	of	IN
cord-306904-8iteddug	737	5	interest	interest	NN
cord-306904-8iteddug	737	6	were	be	VBD
cord-306904-8iteddug	737	7	disclosed	disclose	VBN
cord-306904-8iteddug	737	8	.	.	.
cord-306904-8iteddug	738	1	Digested	digested	JJ
cord-306904-8iteddug	738	2	disorder	disorder	NN
cord-306904-8iteddug	738	3	:	:	:
cord-306904-8iteddug	739	1	quarterly	quarterly	JJ
cord-306904-8iteddug	739	2	intrinsic	intrinsic	JJ
cord-306904-8iteddug	739	3	disorder	disorder	NN
cord-306904-8iteddug	739	4	digest	digest	NN
cord-306904-8iteddug	739	5	Digested	digested	JJ
cord-306904-8iteddug	739	6	disorder	disorder	NN
cord-306904-8iteddug	739	7	,	,	,
cord-306904-8iteddug	739	8	issue	issue	NN
cord-306904-8iteddug	739	9	#	#	$
cord-306904-8iteddug	739	10	2	2	CD
cord-306904-8iteddug	739	11	:	:	:
cord-306904-8iteddug	740	1	quarterly	quarterly	JJ
cord-306904-8iteddug	740	2	intrinsic	intrinsic	JJ
cord-306904-8iteddug	740	3	disorder	disorder	NN
cord-306904-8iteddug	740	4	digest	digest	NN
cord-306904-8iteddug	740	5	Digested	digested	JJ
cord-306904-8iteddug	740	6	disorder	disorder	NN
cord-306904-8iteddug	740	7	,	,	,
cord-306904-8iteddug	740	8	issue	issue	NN
cord-306904-8iteddug	740	9	#	#	NN
cord-306904-8iteddug	740	10	3	3	CD
cord-306904-8iteddug	740	11	:	:	:
cord-306904-8iteddug	741	1	quarterly	quarterly	JJ
cord-306904-8iteddug	741	2	intrinsic	intrinsic	JJ
cord-306904-8iteddug	741	3	disorder	disorder	NN
cord-306904-8iteddug	741	4	digest	digest	VBP
cord-306904-8iteddug	741	5	Comprehensive	Comprehensive	NNP
cord-306904-8iteddug	741	6	comparative	comparative	JJ
cord-306904-8iteddug	741	7	assessment	assessment	NN
cord-306904-8iteddug	741	8	of	of	IN
cord-306904-8iteddug	741	9	in	in	IN
cord-306904-8iteddug	741	10	-	-	HYPH
cord-306904-8iteddug	741	11	silico	silico	NN
cord-306904-8iteddug	741	12	predictors	predictor	NNS
cord-306904-8iteddug	741	13	of	of	IN
cord-306904-8iteddug	741	14	disordered	disordered	JJ
cord-306904-8iteddug	741	15	regions	region	NNS
cord-306904-8iteddug	741	16	eIF4B	eif4b	CD
cord-306904-8iteddug	741	17	and	and	CC
cord-306904-8iteddug	741	18	eIF4	eIF4	NNP
cord-306904-8iteddug	741	19	G	G	NNP
cord-306904-8iteddug	741	20	jointly	jointly	RB
cord-306904-8iteddug	741	21	stimulate	stimulate	VB
cord-306904-8iteddug	741	22	eIF4A	eif4a	CD
cord-306904-8iteddug	741	23	ATPase	atpase	NN
cord-306904-8iteddug	741	24	and	and	CC
cord-306904-8iteddug	741	25	unwinding	unwind	VBG
cord-306904-8iteddug	741	26	activities	activity	NNS
cord-306904-8iteddug	741	27	by	by	IN
cord-306904-8iteddug	741	28	modulation	modulation	NN
cord-306904-8iteddug	741	29	of	of	IN
cord-306904-8iteddug	741	30	the	the	DT
cord-306904-8iteddug	741	31	eIF4A	eif4a	CD
cord-306904-8iteddug	741	32	conformational	conformational	JJ
cord-306904-8iteddug	741	33	cycle	cycle	NN
cord-306904-8iteddug	741	34	New	new	JJ
cord-306904-8iteddug	741	35	initiation	initiation	NN
cord-306904-8iteddug	741	36	factor	factor	NN
cord-306904-8iteddug	741	37	activity	activity	NN
cord-306904-8iteddug	741	38	required	require	VBN
cord-306904-8iteddug	741	39	for	for	IN
cord-306904-8iteddug	741	40	globin	globin	NN
cord-306904-8iteddug	741	41	mRNA	mRNA	NNP
cord-306904-8iteddug	741	42	translation	translation	NN
cord-306904-8iteddug	742	1	The	the	DT
cord-306904-8iteddug	742	2	mechanism	mechanism	NN
cord-306904-8iteddug	742	3	of	of	IN
cord-306904-8iteddug	742	4	eukaryotic	eukaryotic	JJ
cord-306904-8iteddug	742	5	translation	translation	NN
cord-306904-8iteddug	742	6	initiation	initiation	NN
cord-306904-8iteddug	742	7	and	and	CC
cord-306904-8iteddug	742	8	principles	principle	NNS
cord-306904-8iteddug	742	9	of	of	IN
cord-306904-8iteddug	742	10	its	-PRON-	PRP$
cord-306904-8iteddug	742	11	regulation	regulation	NN
cord-306904-8iteddug	743	1	Molecular	molecular	JJ
cord-306904-8iteddug	743	2	mechanism	mechanism	NN
cord-306904-8iteddug	743	3	of	of	IN
cord-306904-8iteddug	743	4	scanning	scanning	NN
cord-306904-8iteddug	743	5	and	and	CC
cord-306904-8iteddug	743	6	start	start	VB
cord-306904-8iteddug	743	7	codon	codon	NN
cord-306904-8iteddug	743	8	selection	selection	NN
cord-306904-8iteddug	743	9	in	in	IN
cord-306904-8iteddug	743	10	eukaryotes	eukaryote	NNS
cord-306904-8iteddug	743	11	mRNA	mRNA	NNP
cord-306904-8iteddug	743	12	helicases	helicase	NNS
cord-306904-8iteddug	743	13	:	:	:
cord-306904-8iteddug	743	14	the	the	DT
cord-306904-8iteddug	743	15	tacticians	tactician	NNS
cord-306904-8iteddug	743	16	of	of	IN
cord-306904-8iteddug	743	17	translational	translational	JJ
cord-306904-8iteddug	743	18	control	control	NN
cord-306904-8iteddug	744	1	The	the	DT
cord-306904-8iteddug	744	2	DEAD	DEAD	NNP
cord-306904-8iteddug	744	3	-	-	HYPH
cord-306904-8iteddug	744	4	box	box	NN
cord-306904-8iteddug	744	5	helicase	helicase	NN
cord-306904-8iteddug	744	6	eIF4A	eif4a	CD
cord-306904-8iteddug	744	7	:	:	:
cord-306904-8iteddug	744	8	paradigm	paradigm	NN
cord-306904-8iteddug	744	9	or	or	CC
cord-306904-8iteddug	744	10	the	the	DT
cord-306904-8iteddug	744	11	odd	odd	JJ
cord-306904-8iteddug	744	12	one	one	NN
cord-306904-8iteddug	744	13	out	out	RP
cord-306904-8iteddug	745	1	Exploiting	exploit	VBG
cord-306904-8iteddug	745	2	heterogeneous	heterogeneous	JJ
cord-306904-8iteddug	745	3	sequence	sequence	NN
cord-306904-8iteddug	745	4	properties	property	NNS
cord-306904-8iteddug	745	5	improves	improve	VBZ
cord-306904-8iteddug	745	6	prediction	prediction	NN
cord-306904-8iteddug	745	7	of	of	IN
cord-306904-8iteddug	745	8	protein	protein	NN
cord-306904-8iteddug	745	9	disorder	disorder	NN
cord-306904-8iteddug	745	10	Predicting	predict	VBG
cord-306904-8iteddug	745	11	intrinsic	intrinsic	JJ
cord-306904-8iteddug	745	12	disorder	disorder	NN
cord-306904-8iteddug	745	13	from	from	IN
cord-306904-8iteddug	745	14	amino	amino	NN
cord-306904-8iteddug	745	15	acid	acid	NN
cord-306904-8iteddug	745	16	sequence	sequence	NN
cord-306904-8iteddug	745	17	Sequence	sequence	NN
cord-306904-8iteddug	745	18	complexity	complexity	NN
cord-306904-8iteddug	745	19	of	of	IN
cord-306904-8iteddug	745	20	disordered	disordered	JJ
cord-306904-8iteddug	745	21	protein	protein	NN
cord-306904-8iteddug	746	1	PONDR	PONDR	NNP
cord-306904-8iteddug	746	2	-	-	HYPH
cord-306904-8iteddug	746	3	FIT	fit	NN
cord-306904-8iteddug	746	4	:	:	:
cord-306904-8iteddug	747	1	a	a	DT
cord-306904-8iteddug	747	2	meta	meta	JJ
cord-306904-8iteddug	747	3	-	-	HYPH
cord-306904-8iteddug	747	4	predictor	predictor	NN
cord-306904-8iteddug	747	5	of	of	IN
cord-306904-8iteddug	747	6	intrinsically	intrinsically	RB
cord-306904-8iteddug	747	7	disordered	disordered	JJ
cord-306904-8iteddug	747	8	amino	amino	NN
cord-306904-8iteddug	747	9	acids	acid	NNS
cord-306904-8iteddug	747	10	Prediction	Prediction	NNP
cord-306904-8iteddug	747	11	of	of	IN
cord-306904-8iteddug	747	12	protein	protein	NN
cord-306904-8iteddug	747	13	binding	bind	VBG
cord-306904-8iteddug	747	14	regions	region	NNS
cord-306904-8iteddug	747	15	in	in	IN
cord-306904-8iteddug	747	16	disordered	disordered	JJ
cord-306904-8iteddug	747	17	proteins	protein	NNS
cord-306904-8iteddug	747	18	ANCHOR	anchor	NN
cord-306904-8iteddug	747	19	:	:	:
cord-306904-8iteddug	747	20	web	web	NN
cord-306904-8iteddug	747	21	server	server	NN
cord-306904-8iteddug	747	22	for	for	IN
cord-306904-8iteddug	747	23	predicting	predict	VBG
cord-306904-8iteddug	747	24	protein	protein	NN
cord-306904-8iteddug	747	25	binding	bind	VBG
cord-306904-8iteddug	747	26	regions	region	NNS
cord-306904-8iteddug	747	27	in	in	IN
cord-306904-8iteddug	747	28	disordered	disordered	JJ
cord-306904-8iteddug	747	29	proteins	protein	NNS
cord-306904-8iteddug	747	30	Remarkable	remarkable	JJ
cord-306904-8iteddug	747	31	stabilization	stabilization	NN
cord-306904-8iteddug	747	32	of	of	IN
cord-306904-8iteddug	747	33	plasminogen	plasminogen	NN
cord-306904-8iteddug	747	34	activator	activator	NN
cord-306904-8iteddug	747	35	inhibitor	inhibitor	NN
cord-306904-8iteddug	747	36	1	1	CD
cord-306904-8iteddug	747	37	in	in	IN
cord-306904-8iteddug	747	38	a	a	DT
cord-306904-8iteddug	747	39	"	"	``
cord-306904-8iteddug	747	40	molecular	molecular	JJ
cord-306904-8iteddug	747	41	sandwich	sandwich	NN
cord-306904-8iteddug	747	42	"	"	''
cord-306904-8iteddug	747	43	complex	complex	JJ
cord-306904-8iteddug	747	44	Interaction	Interaction	NNP
cord-306904-8iteddug	747	45	of	of	IN
cord-306904-8iteddug	747	46	T4	T4	NNP
cord-306904-8iteddug	747	47	UvsW	UvsW	NNP
cord-306904-8iteddug	747	48	helicase	helicase	NN
cord-306904-8iteddug	747	49	and	and	CC
cord-306904-8iteddug	747	50	single	single	RB
cord-306904-8iteddug	747	51	-	-	HYPH
cord-306904-8iteddug	747	52	stranded	strand	VBN
cord-306904-8iteddug	747	53	DNA	dna	NN
cord-306904-8iteddug	747	54	binding	binding	NN
cord-306904-8iteddug	747	55	protein	protein	NN
cord-306904-8iteddug	747	56	gp32	gp32	NNP
cord-306904-8iteddug	747	57	through	through	IN
cord-306904-8iteddug	747	58	its	-PRON-	PRP$
cord-306904-8iteddug	747	59	carboxy	carboxy	JJ
cord-306904-8iteddug	747	60	-	-	HYPH
cord-306904-8iteddug	747	61	terminal	terminal	NN
cord-306904-8iteddug	747	62	acidic	acidic	JJ
cord-306904-8iteddug	747	63	tail	tail	NN
cord-306904-8iteddug	747	64	Crystallographic	Crystallographic	NNP
cord-306904-8iteddug	747	65	and	and	CC
cord-306904-8iteddug	747	66	NMR	NMR	NNP
cord-306904-8iteddug	747	67	analyses	analysis	NNS
cord-306904-8iteddug	747	68	of	of	IN
cord-306904-8iteddug	747	69	UvsW	UvsW	NNP
cord-306904-8iteddug	747	70	and	and	CC
cord-306904-8iteddug	747	71	UvsW.1	UvsW.1	NNP
cord-306904-8iteddug	747	72	from	from	IN
cord-306904-8iteddug	747	73	bacteriophage	bacteriophage	NN
cord-306904-8iteddug	747	74	T4	T4	NNP
cord-306904-8iteddug	747	75	DNA	DNA	NNP
cord-306904-8iteddug	747	76	helicases	helicase	NNS
cord-306904-8iteddug	747	77	:	:	:
cord-306904-8iteddug	747	78	new	new	JJ
cord-306904-8iteddug	747	79	breeds	breed	NNS
cord-306904-8iteddug	747	80	of	of	IN
cord-306904-8iteddug	747	81	translocating	translocate	VBG
cord-306904-8iteddug	747	82	motors	motor	NNS
cord-306904-8iteddug	747	83	and	and	CC
cord-306904-8iteddug	748	1	molecular	molecular	JJ
cord-306904-8iteddug	748	2	pumps	pump	VBZ
cord-306904-8iteddug	748	3	Analysis	Analysis	NNP
cord-306904-8iteddug	748	4	of	of	IN
cord-306904-8iteddug	748	5	the	the	DT
cord-306904-8iteddug	748	6	DNA	dna	NN
cord-306904-8iteddug	748	7	translocation	translocation	NN
cord-306904-8iteddug	748	8	and	and	CC
cord-306904-8iteddug	749	1	unwinding	unwind	VBG
cord-306904-8iteddug	749	2	activities	activity	NNS
cord-306904-8iteddug	749	3	of	of	IN
cord-306904-8iteddug	749	4	T4	T4	NNP
cord-306904-8iteddug	749	5	phage	phage	NN
cord-306904-8iteddug	749	6	helicases	helicase	NNS
cord-306904-8iteddug	750	1	UvsW	UvsW	NNP
cord-306904-8iteddug	750	2	protein	protein	NN
cord-306904-8iteddug	750	3	regulates	regulate	VBZ
cord-306904-8iteddug	750	4	bacteriophage	bacteriophage	NN
cord-306904-8iteddug	750	5	T4	T4	NNP
cord-306904-8iteddug	750	6	origin	origin	NN
cord-306904-8iteddug	750	7	-	-	HYPH
cord-306904-8iteddug	750	8	dependent	dependent	JJ
cord-306904-8iteddug	750	9	replication	replication	NN
cord-306904-8iteddug	750	10	by	by	IN
cord-306904-8iteddug	750	11	unwinding	unwind	VBG
cord-306904-8iteddug	750	12	R	r	NN
cord-306904-8iteddug	750	13	-	-	HYPH
cord-306904-8iteddug	750	14	loops	loop	NNS
cord-306904-8iteddug	750	15	DNA	dna	NN
cord-306904-8iteddug	750	16	helicase	helicase	NN
cord-306904-8iteddug	750	17	requirements	requirement	NNS
cord-306904-8iteddug	750	18	for	for	IN
cord-306904-8iteddug	750	19	DNA	dna	NN
cord-306904-8iteddug	750	20	replication	replication	NN
cord-306904-8iteddug	750	21	during	during	IN
cord-306904-8iteddug	750	22	bacteriophage	bacteriophage	NN
cord-306904-8iteddug	750	23	T4	T4	NNP
cord-306904-8iteddug	750	24	infection	infection	NN
cord-306904-8iteddug	751	1	The	the	DT
cord-306904-8iteddug	751	2	T4	T4	NNP
cord-306904-8iteddug	751	3	phage	phage	NN
cord-306904-8iteddug	752	1	UvsW	UvsW	NNP
cord-306904-8iteddug	752	2	protein	protein	NN
cord-306904-8iteddug	752	3	contains	contain	VBZ
cord-306904-8iteddug	752	4	both	both	CC
cord-306904-8iteddug	752	5	DNA	dna	NN
cord-306904-8iteddug	752	6	unwinding	unwinding	NN
cord-306904-8iteddug	752	7	and	and	CC
cord-306904-8iteddug	752	8	strand	strand	NN
cord-306904-8iteddug	752	9	annealing	annealing	NN
cord-306904-8iteddug	752	10	activities	activity	NNS
cord-306904-8iteddug	753	1	Processive	processive	JJ
cord-306904-8iteddug	753	2	and	and	CC
cord-306904-8iteddug	753	3	unidirectional	unidirectional	JJ
cord-306904-8iteddug	753	4	translocation	translocation	NN
cord-306904-8iteddug	753	5	of	of	IN
cord-306904-8iteddug	753	6	monomeric	monomeric	JJ
cord-306904-8iteddug	753	7	UvsW	UvsW	NNP
cord-306904-8iteddug	753	8	helicase	helicase	NN
cord-306904-8iteddug	753	9	on	on	IN
cord-306904-8iteddug	753	10	single	single	RB
cord-306904-8iteddug	753	11	-	-	HYPH
cord-306904-8iteddug	753	12	stranded	stranded	JJ
cord-306904-8iteddug	753	13	DNA	dna	NN
cord-306904-8iteddug	753	14	Bacteriophage	Bacteriophage	NNP
cord-306904-8iteddug	753	15	T4	T4	NNP
cord-306904-8iteddug	753	16	UvsW	UvsW	NNP
cord-306904-8iteddug	753	17	protein	protein	NN
cord-306904-8iteddug	753	18	is	be	VBZ
cord-306904-8iteddug	753	19	a	a	DT
cord-306904-8iteddug	753	20	helicase	helicase	NN
cord-306904-8iteddug	753	21	involved	involve	VBN
cord-306904-8iteddug	753	22	in	in	IN
cord-306904-8iteddug	753	23	recombination	recombination	NN
cord-306904-8iteddug	753	24	,	,	,
cord-306904-8iteddug	753	25	repair	repair	NN
cord-306904-8iteddug	753	26	and	and	CC
cord-306904-8iteddug	753	27	the	the	DT
cord-306904-8iteddug	753	28	regulation	regulation	NN
cord-306904-8iteddug	753	29	of	of	IN
cord-306904-8iteddug	753	30	DNA	dna	NN
cord-306904-8iteddug	753	31	replication	replication	NN
cord-306904-8iteddug	753	32	origins	origin	NNS
cord-306904-8iteddug	754	1	The	the	DT
cord-306904-8iteddug	754	2	phage	phage	NN
cord-306904-8iteddug	754	3	T4	T4	NNP
cord-306904-8iteddug	754	4	protein	protein	NN
cord-306904-8iteddug	755	1	UvsW	UvsW	NNP
cord-306904-8iteddug	755	2	drives	drive	VBZ
cord-306904-8iteddug	755	3	Holliday	Holliday	NNP
cord-306904-8iteddug	755	4	junction	junction	NN
cord-306904-8iteddug	755	5	branch	branch	NN
cord-306904-8iteddug	755	6	migration	migration	NN
cord-306904-8iteddug	756	1	Repetitive	repetitive	JJ
cord-306904-8iteddug	756	2	lagging	lagging	JJ
cord-306904-8iteddug	756	3	strand	strand	NN
cord-306904-8iteddug	756	4	DNA	dna	NN
cord-306904-8iteddug	756	5	synthesis	synthesis	NN
cord-306904-8iteddug	756	6	by	by	IN
cord-306904-8iteddug	756	7	the	the	DT
cord-306904-8iteddug	756	8	bacteriophage	bacteriophage	NN
cord-306904-8iteddug	756	9	T4	T4	NNP
cord-306904-8iteddug	756	10	replisome	replisome	NNP
cord-306904-8iteddug	756	11	Crystal	Crystal	NNP
cord-306904-8iteddug	756	12	structure	structure	NN
cord-306904-8iteddug	756	13	of	of	IN
cord-306904-8iteddug	756	14	a	a	DT
cord-306904-8iteddug	756	15	replication	replication	NN
cord-306904-8iteddug	756	16	fork	fork	VB
cord-306904-8iteddug	756	17	single	single	RB
cord-306904-8iteddug	756	18	-	-	HYPH
cord-306904-8iteddug	756	19	stranded	strand	VBN
cord-306904-8iteddug	756	20	DNA	dna	NN
cord-306904-8iteddug	756	21	binding	binding	NN
cord-306904-8iteddug	756	22	protein	protein	NN
cord-306904-8iteddug	756	23	(	(	-LRB-
cord-306904-8iteddug	756	24	T4	T4	NNP
cord-306904-8iteddug	756	25	gp32	gp32	NNP
cord-306904-8iteddug	756	26	)	)	-RRB-
cord-306904-8iteddug	756	27	complexed	complexe	VBN
cord-306904-8iteddug	756	28	to	to	IN
cord-306904-8iteddug	756	29	DNA	dna	NN
cord-306904-8iteddug	757	1	The	the	DT
cord-306904-8iteddug	757	2	gene	gene	NN
cord-306904-8iteddug	757	3	59	59	CD
cord-306904-8iteddug	757	4	protein	protein	NN
cord-306904-8iteddug	757	5	of	of	IN
cord-306904-8iteddug	757	6	bacteriophage	bacteriophage	NN
cord-306904-8iteddug	757	7	T4	T4	NNP
cord-306904-8iteddug	757	8	.	.	.
cord-306904-8iteddug	758	1	Characterization	characterization	NN
cord-306904-8iteddug	758	2	of	of	IN
cord-306904-8iteddug	758	3	protein	protein	NN
cord-306904-8iteddug	758	4	-	-	HYPH
cord-306904-8iteddug	758	5	protein	protein	NN
cord-306904-8iteddug	758	6	interactions	interaction	NNS
cord-306904-8iteddug	758	7	with	with	IN
cord-306904-8iteddug	758	8	gene	gene	NN
cord-306904-8iteddug	758	9	32	32	CD
cord-306904-8iteddug	758	10	protein	protein	NN
cord-306904-8iteddug	758	11	,	,	,
cord-306904-8iteddug	758	12	the	the	DT
cord-306904-8iteddug	758	13	T4	T4	NNP
cord-306904-8iteddug	758	14	single	single	RB
cord-306904-8iteddug	758	15	-	-	HYPH
cord-306904-8iteddug	758	16	stranded	strand	VBN
cord-306904-8iteddug	758	17	DNA	dna	NN
cord-306904-8iteddug	758	18	binding	binding	NN
cord-306904-8iteddug	758	19	protein	protein	NN
cord-306904-8iteddug	758	20	Characterization	characterization	NN
cord-306904-8iteddug	758	21	of	of	IN
cord-306904-8iteddug	758	22	bacteriophage	bacteriophage	NN
cord-306904-8iteddug	759	1	T4-coordinated	t4-coordinate	VBN
cord-306904-8iteddug	759	2	leading	lead	VBG
cord-306904-8iteddug	759	3	-	-	:
cord-306904-8iteddug	759	4	and	and	CC
cord-306904-8iteddug	759	5	lagging	lagging	JJ
cord-306904-8iteddug	759	6	-	-	HYPH
cord-306904-8iteddug	759	7	strand	strand	NN
cord-306904-8iteddug	759	8	synthesis	synthesis	NN
cord-306904-8iteddug	759	9	on	on	IN
cord-306904-8iteddug	759	10	a	a	DT
cord-306904-8iteddug	759	11	minicircle	minicircle	NN
cord-306904-8iteddug	759	12	substrate	substrate	NN
cord-306904-8iteddug	759	13	Identification	identification	NN
cord-306904-8iteddug	759	14	and	and	CC
cord-306904-8iteddug	759	15	mapping	mapping	NN
cord-306904-8iteddug	759	16	of	of	IN
cord-306904-8iteddug	759	17	protein	protein	NN
cord-306904-8iteddug	759	18	-	-	HYPH
cord-306904-8iteddug	759	19	protein	protein	NN
cord-306904-8iteddug	759	20	interactions	interaction	NNS
cord-306904-8iteddug	759	21	between	between	IN
cord-306904-8iteddug	759	22	gp32	gp32	NN
cord-306904-8iteddug	759	23	and	and	CC
cord-306904-8iteddug	759	24	gp59	gp59	JJ
cord-306904-8iteddug	759	25	by	by	IN
cord-306904-8iteddug	759	26	cross	cross	NN
cord-306904-8iteddug	759	27	-	-	JJ
cord-306904-8iteddug	759	28	linking	link	VBG
cord-306904-8iteddug	759	29	Functional	functional	JJ
cord-306904-8iteddug	759	30	mapping	mapping	NN
cord-306904-8iteddug	759	31	of	of	IN
cord-306904-8iteddug	759	32	PilF	PilF	NNP
cord-306904-8iteddug	759	33	and	and	CC
cord-306904-8iteddug	759	34	PilQ	PilQ	NNP
cord-306904-8iteddug	759	35	in	in	IN
cord-306904-8iteddug	759	36	the	the	DT
cord-306904-8iteddug	759	37	Pseudomonas	Pseudomonas	NNP
cord-306904-8iteddug	759	38	aeruginosa	aeruginosa	NN
cord-306904-8iteddug	759	39	type	type	NN
cord-306904-8iteddug	759	40	IV	IV	NNP
cord-306904-8iteddug	759	41	pilus	pilus	NN
cord-306904-8iteddug	759	42	system	system	NN
cord-306904-8iteddug	759	43	Structure	structure	NN
cord-306904-8iteddug	759	44	and	and	CC
cord-306904-8iteddug	759	45	function	function	NN
cord-306904-8iteddug	759	46	of	of	IN
cord-306904-8iteddug	759	47	PilQ	PilQ	NNP
cord-306904-8iteddug	759	48	,	,	,
cord-306904-8iteddug	759	49	a	a	DT
cord-306904-8iteddug	759	50	secretin	secretin	NN
cord-306904-8iteddug	759	51	of	of	IN
cord-306904-8iteddug	759	52	the	the	DT
cord-306904-8iteddug	759	53	DNA	dna	NN
cord-306904-8iteddug	759	54	transporter	transporter	NN
cord-306904-8iteddug	759	55	from	from	IN
cord-306904-8iteddug	759	56	the	the	DT
cord-306904-8iteddug	759	57	thermophilic	thermophilic	JJ
cord-306904-8iteddug	759	58	bacterium	bacterium	NN
cord-306904-8iteddug	760	1	Thermus	Thermus	NNP
cord-306904-8iteddug	760	2	thermophilus	thermophilus	NNP
cord-306904-8iteddug	760	3	HB27	HB27	NNP
cord-306904-8iteddug	760	4	Secretins	Secretins	NNPS
cord-306904-8iteddug	760	5	:	:	:
cord-306904-8iteddug	760	6	dynamic	dynamic	JJ
cord-306904-8iteddug	760	7	channels	channel	NNS
cord-306904-8iteddug	760	8	for	for	IN
cord-306904-8iteddug	760	9	protein	protein	NN
cord-306904-8iteddug	760	10	transport	transport	NN
cord-306904-8iteddug	760	11	across	across	IN
cord-306904-8iteddug	760	12	membranes	membrane	NNS
cord-306904-8iteddug	760	13	Characterization	characterization	NN
cord-306904-8iteddug	760	14	of	of	IN
cord-306904-8iteddug	760	15	14	14	CD
cord-306904-8iteddug	760	16	-	-	SYM
cord-306904-8iteddug	760	17	3	3	CD
cord-306904-8iteddug	760	18	-	-	HYPH
cord-306904-8iteddug	760	19	3-zeta	3-zeta	CD
cord-306904-8iteddug	760	20	Interactions	Interactions	NNPS
cord-306904-8iteddug	760	21	with	with	IN
cord-306904-8iteddug	760	22	integrin	integrin	NN
cord-306904-8iteddug	760	23	tails	tail	NNS
cord-306904-8iteddug	760	24	14	14	CD
cord-306904-8iteddug	760	25	-	-	SYM
cord-306904-8iteddug	760	26	3	3	CD
cord-306904-8iteddug	760	27	-	-	SYM
cord-306904-8iteddug	760	28	3	3	CD
cord-306904-8iteddug	760	29	Proteins	Proteins	NNP
cord-306904-8iteddug	760	30	-	-	:
cord-306904-8iteddug	760	31	a	a	DT
cord-306904-8iteddug	760	32	focus	focus	NN
cord-306904-8iteddug	760	33	on	on	IN
cord-306904-8iteddug	760	34	cancer	cancer	NN
cord-306904-8iteddug	760	35	and	and	CC
cord-306904-8iteddug	760	36	human	human	JJ
cord-306904-8iteddug	760	37	disease	disease	NN
cord-306904-8iteddug	760	38	14	14	CD
cord-306904-8iteddug	760	39	-	-	SYM
cord-306904-8iteddug	760	40	3	3	CD
cord-306904-8iteddug	760	41	-	-	SYM
cord-306904-8iteddug	760	42	3	3	CD
cord-306904-8iteddug	760	43	proteins	protein	NNS
cord-306904-8iteddug	760	44	as	as	IN
cord-306904-8iteddug	760	45	potential	potential	JJ
cord-306904-8iteddug	760	46	therapeutic	therapeutic	JJ
cord-306904-8iteddug	760	47	targets	target	NNS
cord-306904-8iteddug	760	48	Cantley	Cantley	NNP
cord-306904-8iteddug	760	49	LC	LC	NNP
cord-306904-8iteddug	760	50	.	.	.
cord-306904-8iteddug	761	1	The	the	DT
cord-306904-8iteddug	761	2	structural	structural	JJ
cord-306904-8iteddug	761	3	basis	basis	NN
cord-306904-8iteddug	761	4	for	for	IN
cord-306904-8iteddug	761	5	14	14	CD
cord-306904-8iteddug	761	6	-	-	SYM
cord-306904-8iteddug	761	7	3	3	CD
cord-306904-8iteddug	761	8	-	-	SYM
cord-306904-8iteddug	761	9	3	3	CD
cord-306904-8iteddug	761	10	:	:	:
cord-306904-8iteddug	761	11	phosphopeptide	phosphopeptide	NN
cord-306904-8iteddug	761	12	binding	bind	VBG
cord-306904-8iteddug	761	13	specificity	specificity	NN
cord-306904-8iteddug	761	14	Binding	binding	NN
cord-306904-8iteddug	761	15	of	of	IN
cord-306904-8iteddug	761	16	14	14	CD
cord-306904-8iteddug	761	17	-	-	SYM
cord-306904-8iteddug	761	18	3	3	CD
cord-306904-8iteddug	761	19	-	-	SYM
cord-306904-8iteddug	761	20	3	3	CD
cord-306904-8iteddug	761	21	protein	protein	NN
cord-306904-8iteddug	761	22	to	to	IN
cord-306904-8iteddug	761	23	the	the	DT
cord-306904-8iteddug	761	24	plasma	plasma	NN
cord-306904-8iteddug	761	25	membrane	membrane	NN
cord-306904-8iteddug	762	1	H(C)-ATPase	H(C)-ATPase	NNP
cord-306904-8iteddug	762	2	AHA2	AHA2	NNP
cord-306904-8iteddug	762	3	involves	involve	VBZ
cord-306904-8iteddug	762	4	the	the	DT
cord-306904-8iteddug	762	5	three	three	CD
cord-306904-8iteddug	762	6	C	c	NN
cord-306904-8iteddug	762	7	-	-	HYPH
cord-306904-8iteddug	762	8	terminal	terminal	NN
cord-306904-8iteddug	762	9	residues	residue	NNS
cord-306904-8iteddug	762	10	Tyr(946)-Thr	Tyr(946)-Thr	NNP
cord-306904-8iteddug	762	11	-	-	HYPH
cord-306904-8iteddug	762	12	Val	val	NN
cord-306904-8iteddug	762	13	and	and	CC
cord-306904-8iteddug	762	14	requires	require	VBZ
cord-306904-8iteddug	762	15	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	762	16	of	of	IN
cord-306904-8iteddug	762	17	Thr(947	Thr(947	NNP
cord-306904-8iteddug	762	18	)	)	-RRB-
cord-306904-8iteddug	763	1	ATM	atm	NN
cord-306904-8iteddug	763	2	-	-	HYPH
cord-306904-8iteddug	763	3	dependent	dependent	JJ
cord-306904-8iteddug	763	4	activation	activation	NN
cord-306904-8iteddug	763	5	of	of	IN
cord-306904-8iteddug	763	6	p53	p53	NN
cord-306904-8iteddug	763	7	involves	involve	VBZ
cord-306904-8iteddug	763	8	dephosphorylation	dephosphorylation	NN
cord-306904-8iteddug	763	9	and	and	CC
cord-306904-8iteddug	763	10	association	association	NN
cord-306904-8iteddug	763	11	with	with	IN
cord-306904-8iteddug	763	12	14	14	CD
cord-306904-8iteddug	763	13	-	-	SYM
cord-306904-8iteddug	763	14	3	3	CD
cord-306904-8iteddug	763	15	-	-	SYM
cord-306904-8iteddug	763	16	3	3	CD
cord-306904-8iteddug	763	17	proteins	protein	NNS
cord-306904-8iteddug	763	18	Structural	structural	JJ
cord-306904-8iteddug	763	19	determinants	determinant	NNS
cord-306904-8iteddug	763	20	of	of	IN
cord-306904-8iteddug	763	21	14	14	CD
cord-306904-8iteddug	763	22	-	-	SYM
cord-306904-8iteddug	763	23	3	3	CD
cord-306904-8iteddug	763	24	-	-	SYM
cord-306904-8iteddug	763	25	3	3	CD
cord-306904-8iteddug	763	26	binding	binding	NN
cord-306904-8iteddug	763	27	specificities	specificity	NNS
cord-306904-8iteddug	763	28	and	and	CC
cord-306904-8iteddug	763	29	regulation	regulation	NN
cord-306904-8iteddug	763	30	of	of	IN
cord-306904-8iteddug	763	31	subcellular	subcellular	JJ
cord-306904-8iteddug	763	32	localization	localization	NN
cord-306904-8iteddug	763	33	of	of	IN
cord-306904-8iteddug	763	34	14	14	CD
cord-306904-8iteddug	763	35	-	-	SYM
cord-306904-8iteddug	763	36	3	3	CD
cord-306904-8iteddug	763	37	-	-	SYM
cord-306904-8iteddug	763	38	3-ligand	3-ligand	CD
cord-306904-8iteddug	763	39	complexes	complex	NNS
cord-306904-8iteddug	763	40	:	:	:
cord-306904-8iteddug	763	41	a	a	DT
cord-306904-8iteddug	763	42	comparison	comparison	NN
cord-306904-8iteddug	763	43	of	of	IN
cord-306904-8iteddug	763	44	the	the	DT
cord-306904-8iteddug	763	45	X	x	NN
cord-306904-8iteddug	763	46	-	-	NN
cord-306904-8iteddug	763	47	ray	ray	NN
cord-306904-8iteddug	763	48	crystal	crystal	NN
cord-306904-8iteddug	763	49	structures	structure	NNS
cord-306904-8iteddug	763	50	of	of	IN
cord-306904-8iteddug	763	51	all	all	DT
cord-306904-8iteddug	763	52	human	human	JJ
cord-306904-8iteddug	763	53	14	14	CD
cord-306904-8iteddug	763	54	-	-	SYM
cord-306904-8iteddug	763	55	3	3	CD
cord-306904-8iteddug	763	56	-	-	SYM
cord-306904-8iteddug	763	57	3	3	CD
cord-306904-8iteddug	763	58	isoforms	isoform	NNS
cord-306904-8iteddug	763	59	Structural	structural	JJ
cord-306904-8iteddug	763	60	basis	basis	NN
cord-306904-8iteddug	763	61	of	of	IN
cord-306904-8iteddug	763	62	14	14	CD
cord-306904-8iteddug	763	63	-	-	SYM
cord-306904-8iteddug	763	64	3	3	CD
cord-306904-8iteddug	763	65	-	-	SYM
cord-306904-8iteddug	763	66	3	3	CD
cord-306904-8iteddug	763	67	protein	protein	NN
cord-306904-8iteddug	763	68	functions	function	NNS
cord-306904-8iteddug	763	69	Intrinsic	intrinsic	JJ
cord-306904-8iteddug	763	70	disorder	disorder	NN
cord-306904-8iteddug	763	71	is	be	VBZ
cord-306904-8iteddug	763	72	a	a	DT
cord-306904-8iteddug	763	73	key	key	JJ
cord-306904-8iteddug	763	74	characteristic	characteristic	NN
cord-306904-8iteddug	763	75	in	in	IN
cord-306904-8iteddug	763	76	partners	partner	NNS
cord-306904-8iteddug	763	77	that	that	WDT
cord-306904-8iteddug	763	78	bind	bind	VBP
cord-306904-8iteddug	763	79	14	14	CD
cord-306904-8iteddug	763	80	-	-	SYM
cord-306904-8iteddug	763	81	3	3	CD
cord-306904-8iteddug	763	82	-	-	SYM
cord-306904-8iteddug	763	83	3	3	CD
cord-306904-8iteddug	763	84	proteins	protein	NNS
cord-306904-8iteddug	763	85	Integrins	Integrins	NNPS
cord-306904-8iteddug	763	86	:	:	:
cord-306904-8iteddug	763	87	bidirectional	bidirectional	JJ
cord-306904-8iteddug	763	88	,	,	,
cord-306904-8iteddug	763	89	allosteric	allosteric	JJ
cord-306904-8iteddug	763	90	signaling	signal	VBG
cord-306904-8iteddug	763	91	machines	machine	NNS
cord-306904-8iteddug	763	92	Integrin	Integrin	NNP
cord-306904-8iteddug	763	93	signalling	signal	VBG
cord-306904-8iteddug	763	94	at	at	IN
cord-306904-8iteddug	763	95	a	a	DT
cord-306904-8iteddug	763	96	glance	glance	NN
cord-306904-8iteddug	764	1	The	the	DT
cord-306904-8iteddug	764	2	tail	tail	NN
cord-306904-8iteddug	764	3	of	of	IN
cord-306904-8iteddug	764	4	integrin	integrin	NN
cord-306904-8iteddug	764	5	activation	activation	NN
cord-306904-8iteddug	764	6	Integrin	Integrin	NNP
cord-306904-8iteddug	764	7	cytoplasmic	cytoplasmic	JJ
cord-306904-8iteddug	764	8	domain	domain	NN
cord-306904-8iteddug	764	9	-	-	HYPH
cord-306904-8iteddug	764	10	binding	bind	VBG
cord-306904-8iteddug	764	11	proteins	protein	NNS
cord-306904-8iteddug	764	12	Mechanisms	mechanism	NNS
cord-306904-8iteddug	764	13	that	that	WDT
cord-306904-8iteddug	764	14	regulate	regulate	VBP
cord-306904-8iteddug	764	15	adaptor	adaptor	NN
cord-306904-8iteddug	764	16	binding	bind	VBG
cord-306904-8iteddug	764	17	to	to	IN
cord-306904-8iteddug	764	18	beta	beta	NN
cord-306904-8iteddug	764	19	-	-	HYPH
cord-306904-8iteddug	764	20	integrin	integrin	JJ
cord-306904-8iteddug	764	21	cytoplasmic	cytoplasmic	JJ
cord-306904-8iteddug	764	22	tails	tail	NNS
cord-306904-8iteddug	765	1	The	the	DT
cord-306904-8iteddug	765	2	final	final	JJ
cord-306904-8iteddug	765	3	steps	step	NNS
cord-306904-8iteddug	765	4	of	of	IN
cord-306904-8iteddug	765	5	integrin	integrin	NN
cord-306904-8iteddug	765	6	activation	activation	NN
cord-306904-8iteddug	765	7	:	:	:
cord-306904-8iteddug	765	8	the	the	DT
cord-306904-8iteddug	765	9	end	end	NN
cord-306904-8iteddug	765	10	game	game	NN
cord-306904-8iteddug	765	11	Beta2	Beta2	NNS
cord-306904-8iteddug	765	12	integrin	integrin	NN
cord-306904-8iteddug	765	13	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	765	14	on	on	IN
cord-306904-8iteddug	765	15	Thr758	thr758	CD
cord-306904-8iteddug	765	16	acts	act	NNS
cord-306904-8iteddug	765	17	as	as	IN
cord-306904-8iteddug	765	18	a	a	DT
cord-306904-8iteddug	765	19	molecular	molecular	JJ
cord-306904-8iteddug	765	20	switch	switch	NN
cord-306904-8iteddug	765	21	to	to	TO
cord-306904-8iteddug	765	22	regulate	regulate	VB
cord-306904-8iteddug	765	23	14	14	CD
cord-306904-8iteddug	765	24	-	-	SYM
cord-306904-8iteddug	765	25	3	3	CD
cord-306904-8iteddug	765	26	-	-	SYM
cord-306904-8iteddug	765	27	3	3	CD
cord-306904-8iteddug	765	28	and	and	CC
cord-306904-8iteddug	765	29	filamin	filamin	NNP
cord-306904-8iteddug	765	30	binding	bind	VBG
cord-306904-8iteddug	765	31	TRIMmunity	trimmunity	NN
cord-306904-8iteddug	765	32	:	:	:
cord-306904-8iteddug	765	33	the	the	DT
cord-306904-8iteddug	765	34	roles	role	NNS
cord-306904-8iteddug	765	35	of	of	IN
cord-306904-8iteddug	765	36	the	the	DT
cord-306904-8iteddug	765	37	TRIM	trim	NN
cord-306904-8iteddug	765	38	E3-ubiquitin	e3-ubiquitin	NN
cord-306904-8iteddug	765	39	ligase	ligase	NN
cord-306904-8iteddug	765	40	family	family	NN
cord-306904-8iteddug	765	41	in	in	IN
cord-306904-8iteddug	765	42	innate	innate	JJ
cord-306904-8iteddug	765	43	antiviral	antiviral	JJ
cord-306904-8iteddug	765	44	immunity	immunity	NN
cord-306904-8iteddug	765	45	A	a	DT
cord-306904-8iteddug	765	46	unique	unique	JJ
cord-306904-8iteddug	765	47	bipartite	bipartite	JJ
cord-306904-8iteddug	765	48	cysteinehistidine	cysteinehistidine	NN
cord-306904-8iteddug	765	49	motif	motif	NN
cord-306904-8iteddug	765	50	defines	define	VBZ
cord-306904-8iteddug	765	51	a	a	DT
cord-306904-8iteddug	765	52	subfamily	subfamily	NN
cord-306904-8iteddug	765	53	of	of	IN
cord-306904-8iteddug	765	54	potential	potential	JJ
cord-306904-8iteddug	765	55	zincfinger	zincfinger	NN
cord-306904-8iteddug	765	56	proteins	protein	NNS
cord-306904-8iteddug	766	1	A	a	DT
cord-306904-8iteddug	766	2	novel	novel	NN
cord-306904-8iteddug	766	3	zinc	zinc	NN
cord-306904-8iteddug	766	4	finger	finger	NN
cord-306904-8iteddug	766	5	coiled	coil	VBN
cord-306904-8iteddug	766	6	-	-	HYPH
cord-306904-8iteddug	766	7	coil	coil	NN
cord-306904-8iteddug	766	8	domain	domain	NN
cord-306904-8iteddug	766	9	in	in	IN
cord-306904-8iteddug	766	10	a	a	DT
cord-306904-8iteddug	766	11	family	family	NN
cord-306904-8iteddug	766	12	of	of	IN
cord-306904-8iteddug	766	13	nuclear	nuclear	JJ
cord-306904-8iteddug	766	14	proteins	protein	NNS
cord-306904-8iteddug	767	1	A	a	DT
cord-306904-8iteddug	767	2	novel	novel	JJ
cord-306904-8iteddug	767	3	protein	protein	NN
cord-306904-8iteddug	767	4	sequence	sequence	NN
cord-306904-8iteddug	767	5	motif	motif	NN
cord-306904-8iteddug	767	6	related	relate	VBN
cord-306904-8iteddug	767	7	to	to	IN
cord-306904-8iteddug	767	8	the	the	DT
cord-306904-8iteddug	767	9	zinc	zinc	NN
cord-306904-8iteddug	767	10	finger	finger	NN
cord-306904-8iteddug	767	11	TRIM	TRIM	NNP
cord-306904-8iteddug	767	12	/	/	SYM
cord-306904-8iteddug	767	13	RBCC	RBCC	NNP
cord-306904-8iteddug	767	14	,	,	,
cord-306904-8iteddug	767	15	a	a	DT
cord-306904-8iteddug	767	16	novel	novel	JJ
cord-306904-8iteddug	767	17	class	class	NN
cord-306904-8iteddug	767	18	of	of	IN
cord-306904-8iteddug	767	19	'	'	``
cord-306904-8iteddug	767	20	single	single	JJ
cord-306904-8iteddug	767	21	protein	protein	NN
cord-306904-8iteddug	767	22	RING	ring	NN
cord-306904-8iteddug	767	23	finger	finger	NN
cord-306904-8iteddug	767	24	'	'	''
cord-306904-8iteddug	767	25	E3	e3	NN
cord-306904-8iteddug	767	26	ubiquitin	ubiquitin	NN
cord-306904-8iteddug	767	27	ligases	ligase	NNS
cord-306904-8iteddug	768	1	The	the	DT
cord-306904-8iteddug	768	2	role	role	NN
cord-306904-8iteddug	768	3	of	of	IN
cord-306904-8iteddug	768	4	viperin	viperin	NNP
cord-306904-8iteddug	768	5	in	in	IN
cord-306904-8iteddug	768	6	the	the	DT
cord-306904-8iteddug	768	7	innate	innate	JJ
cord-306904-8iteddug	768	8	antiviral	antiviral	JJ
cord-306904-8iteddug	768	9	response	response	NN
cord-306904-8iteddug	768	10	The	the	DT
cord-306904-8iteddug	768	11	STRING	string	NN
cord-306904-8iteddug	768	12	database	database	NN
cord-306904-8iteddug	768	13	in	in	IN
cord-306904-8iteddug	768	14	2011	2011	CD
cord-306904-8iteddug	768	15	:	:	:
cord-306904-8iteddug	768	16	functional	functional	JJ
cord-306904-8iteddug	768	17	interaction	interaction	NN
cord-306904-8iteddug	768	18	networks	network	NNS
cord-306904-8iteddug	768	19	of	of	IN
cord-306904-8iteddug	768	20	proteins	protein	NNS
cord-306904-8iteddug	768	21	,	,	,
cord-306904-8iteddug	768	22	globally	globally	RB
cord-306904-8iteddug	768	23	integrated	integrate	VBN
cord-306904-8iteddug	768	24	and	and	CC
cord-306904-8iteddug	768	25	scored	score	VBD
cord-306904-8iteddug	768	26	A	a	DT
cord-306904-8iteddug	768	27	molecular	molecular	JJ
cord-306904-8iteddug	768	28	dynamics	dynamic	NNS
cord-306904-8iteddug	768	29	simulation	simulation	NN
cord-306904-8iteddug	768	30	-	-	HYPH
cord-306904-8iteddug	768	31	based	base	VBN
cord-306904-8iteddug	768	32	interpretation	interpretation	NN
cord-306904-8iteddug	768	33	of	of	IN
cord-306904-8iteddug	768	34	nuclear	nuclear	JJ
cord-306904-8iteddug	768	35	magnetic	magnetic	JJ
cord-306904-8iteddug	768	36	resonance	resonance	NN
cord-306904-8iteddug	768	37	multidimensional	multidimensional	JJ
cord-306904-8iteddug	768	38	heteronuclear	heteronuclear	NNP
cord-306904-8iteddug	768	39	spectra	spectrum	NNS
cord-306904-8iteddug	768	40	of	of	IN
cord-306904-8iteddug	768	41	alpha	alpha	NNP
cord-306904-8iteddug	768	42	-	-	HYPH
cord-306904-8iteddug	768	43	synuclein	synuclein	NNP
cord-306904-8iteddug	768	44	dopamine	dopamine	NN
cord-306904-8iteddug	768	45	adducts	adduct	VBZ
cord-306904-8iteddug	768	46	HIV-1	HIV-1	NNP
cord-306904-8iteddug	768	47	restriction	restriction	NN
cord-306904-8iteddug	768	48	factor	factor	NN
cord-306904-8iteddug	769	1	SAMHD1	SAMHD1	NNPS
cord-306904-8iteddug	769	2	is	be	VBZ
cord-306904-8iteddug	769	3	a	a	DT
cord-306904-8iteddug	769	4	deoxynucleoside	deoxynucleoside	JJ
cord-306904-8iteddug	769	5	triphosphate	triphosphate	NN
cord-306904-8iteddug	769	6	triphosphohydrolase	triphosphohydrolase	NN
cord-306904-8iteddug	769	7	Nuclease	Nuclease	NNP
cord-306904-8iteddug	769	8	activity	activity	NN
cord-306904-8iteddug	769	9	of	of	IN
cord-306904-8iteddug	769	10	the	the	DT
cord-306904-8iteddug	769	11	human	human	NN
cord-306904-8iteddug	769	12	SAMHD1	SAMHD1	NNP
cord-306904-8iteddug	769	13	protein	protein	NN
cord-306904-8iteddug	769	14	implicated	implicate	VBN
cord-306904-8iteddug	769	15	in	in	IN
cord-306904-8iteddug	769	16	the	the	DT
cord-306904-8iteddug	769	17	Aicardi	Aicardi	NNPS
cord-306904-8iteddug	769	18	-	-	HYPH
cord-306904-8iteddug	769	19	Goutieres	Goutieres	NNP
cord-306904-8iteddug	769	20	syndrome	syndrome	NN
cord-306904-8iteddug	769	21	and	and	CC
cord-306904-8iteddug	769	22	HIV-1	HIV-1	NNP
cord-306904-8iteddug	769	23	restriction	restriction	NN
cord-306904-8iteddug	769	24	Contribution	Contribution	NNP
cord-306904-8iteddug	769	25	of	of	IN
cord-306904-8iteddug	769	26	SAM	SAM	NNP
cord-306904-8iteddug	769	27	and	and	CC
cord-306904-8iteddug	769	28	HD	HD	NNP
cord-306904-8iteddug	769	29	domains	domain	NNS
cord-306904-8iteddug	769	30	to	to	IN
cord-306904-8iteddug	769	31	retroviral	retroviral	JJ
cord-306904-8iteddug	769	32	restriction	restriction	NN
cord-306904-8iteddug	769	33	mediated	mediate	VBN
cord-306904-8iteddug	769	34	by	by	IN
cord-306904-8iteddug	769	35	human	human	JJ
cord-306904-8iteddug	769	36	SAMHD1	SAMHD1	NNS
cord-306904-8iteddug	769	37	HIV	HIV	NNP
cord-306904-8iteddug	769	38	/	/	SYM
cord-306904-8iteddug	769	39	simian	simian	JJ
cord-306904-8iteddug	769	40	immunodeficiency	immunodeficiency	NN
cord-306904-8iteddug	769	41	virus	virus	NN
cord-306904-8iteddug	769	42	(	(	-LRB-
cord-306904-8iteddug	769	43	SIV	SIV	NNP
cord-306904-8iteddug	769	44	)	)	-RRB-
cord-306904-8iteddug	769	45	accessory	accessory	JJ
cord-306904-8iteddug	769	46	virulence	virulence	NN
cord-306904-8iteddug	769	47	factor	factor	NN
cord-306904-8iteddug	770	1	Vpx	Vpx	NNP
cord-306904-8iteddug	770	2	loads	load	VBZ
cord-306904-8iteddug	770	3	the	the	DT
cord-306904-8iteddug	770	4	host	host	NN
cord-306904-8iteddug	770	5	cell	cell	NN
cord-306904-8iteddug	770	6	restriction	restriction	NN
cord-306904-8iteddug	770	7	factor	factor	NN
cord-306904-8iteddug	771	1	SAMHD1	SAMHD1	NNS
cord-306904-8iteddug	771	2	onto	onto	IN
cord-306904-8iteddug	771	3	the	the	DT
cord-306904-8iteddug	771	4	E3	e3	NN
cord-306904-8iteddug	771	5	ubiquitin	ubiquitin	NN
cord-306904-8iteddug	771	6	ligase	ligase	NN
cord-306904-8iteddug	771	7	complex	complex	JJ
cord-306904-8iteddug	772	1	CRL4DCAF1	CRL4DCAF1	NNP
cord-306904-8iteddug	773	1	Novel	novel	JJ
cord-306904-8iteddug	773	2	interaction	interaction	NN
cord-306904-8iteddug	773	3	between	between	IN
cord-306904-8iteddug	773	4	the	the	DT
cord-306904-8iteddug	773	5	major	major	JJ
cord-306904-8iteddug	773	6	bacterial	bacterial	JJ
cord-306904-8iteddug	773	7	heat	heat	NN
cord-306904-8iteddug	773	8	shock	shock	NN
cord-306904-8iteddug	773	9	chaperone	chaperone	NN
cord-306904-8iteddug	773	10	(	(	-LRB-
cord-306904-8iteddug	773	11	GroESL	GroESL	NNP
cord-306904-8iteddug	773	12	)	)	-RRB-
cord-306904-8iteddug	773	13	and	and	CC
cord-306904-8iteddug	773	14	an	an	DT
cord-306904-8iteddug	773	15	RNA	RNA	NNP
cord-306904-8iteddug	773	16	chaperone	chaperone	NN
cord-306904-8iteddug	773	17	(	(	-LRB-
cord-306904-8iteddug	773	18	CspC	CspC	NNP
cord-306904-8iteddug	773	19	)	)	-RRB-
cord-306904-8iteddug	773	20	Interplay	interplay	NN
cord-306904-8iteddug	773	21	between	between	IN
cord-306904-8iteddug	773	22	the	the	DT
cord-306904-8iteddug	773	23	heat	heat	NN
cord-306904-8iteddug	773	24	shock	shock	NN
cord-306904-8iteddug	773	25	response	response	NN
cord-306904-8iteddug	773	26	and	and	CC
cord-306904-8iteddug	773	27	translation	translation	NN
cord-306904-8iteddug	773	28	in	in	IN
cord-306904-8iteddug	773	29	Escherichia	Escherichia	NNP
cord-306904-8iteddug	773	30	coli	coli	VBZ
cord-306904-8iteddug	773	31	Proteolysis	Proteolysis	NNP
cord-306904-8iteddug	773	32	in	in	IN
cord-306904-8iteddug	773	33	the	the	DT
cord-306904-8iteddug	773	34	Escherichia	Escherichia	NNP
cord-306904-8iteddug	773	35	coli	coli	NNS
cord-306904-8iteddug	773	36	heat	heat	NN
cord-306904-8iteddug	773	37	shock	shock	NN
cord-306904-8iteddug	773	38	response	response	NN
cord-306904-8iteddug	773	39	:	:	:
cord-306904-8iteddug	773	40	a	a	DT
cord-306904-8iteddug	773	41	player	player	NN
cord-306904-8iteddug	773	42	at	at	IN
cord-306904-8iteddug	773	43	many	many	JJ
cord-306904-8iteddug	773	44	levels	level	NNS
cord-306904-8iteddug	774	1	The	the	DT
cord-306904-8iteddug	774	2	cold	cold	JJ
cord-306904-8iteddug	774	3	-	-	HYPH
cord-306904-8iteddug	774	4	shock	shock	NN
cord-306904-8iteddug	774	5	response	response	NN
cord-306904-8iteddug	774	6	-	-	:
cord-306904-8iteddug	774	7	a	a	DT
cord-306904-8iteddug	774	8	hot	hot	JJ
cord-306904-8iteddug	774	9	topic	topic	NN
cord-306904-8iteddug	775	1	Recent	recent	JJ
cord-306904-8iteddug	775	2	developments	development	NNS
cord-306904-8iteddug	775	3	in	in	IN
cord-306904-8iteddug	775	4	bacterial	bacterial	JJ
cord-306904-8iteddug	775	5	coldshock	coldshock	NN
cord-306904-8iteddug	775	6	response	response	NN
cord-306904-8iteddug	775	7	Cold	cold	JJ
cord-306904-8iteddug	775	8	-	-	HYPH
cord-306904-8iteddug	775	9	shock	shock	NN
cord-306904-8iteddug	775	10	response	response	NN
cord-306904-8iteddug	775	11	and	and	CC
cord-306904-8iteddug	775	12	cold	cold	JJ
cord-306904-8iteddug	775	13	-	-	HYPH
cord-306904-8iteddug	775	14	shock	shock	NN
cord-306904-8iteddug	775	15	proteins	protein	NNS
cord-306904-8iteddug	776	1	RNA	RNA	NNP
cord-306904-8iteddug	776	2	remodeling	remodeling	NN
cord-306904-8iteddug	776	3	and	and	CC
cord-306904-8iteddug	776	4	gene	gene	NN
cord-306904-8iteddug	776	5	regulation	regulation	NN
cord-306904-8iteddug	776	6	by	by	IN
cord-306904-8iteddug	776	7	cold	cold	JJ
cord-306904-8iteddug	776	8	shock	shock	NN
cord-306904-8iteddug	776	9	proteins	protein	NNS
cord-306904-8iteddug	777	1	The	the	DT
cord-306904-8iteddug	777	2	role	role	NN
cord-306904-8iteddug	777	3	of	of	IN
cord-306904-8iteddug	777	4	structural	structural	JJ
cord-306904-8iteddug	777	5	disorder	disorder	NN
cord-306904-8iteddug	777	6	in	in	IN
cord-306904-8iteddug	777	7	the	the	DT
cord-306904-8iteddug	777	8	function	function	NN
cord-306904-8iteddug	777	9	of	of	IN
cord-306904-8iteddug	777	10	RNA	RNA	NNP
cord-306904-8iteddug	777	11	and	and	CC
cord-306904-8iteddug	777	12	protein	protein	NN
cord-306904-8iteddug	777	13	chaperones	chaperone	NNS
cord-306904-8iteddug	777	14	Interactions	Interactions	NNPS
cord-306904-8iteddug	777	15	of	of	IN
cord-306904-8iteddug	777	16	phosphatase	phosphatase	NN
cord-306904-8iteddug	777	17	and	and	CC
cord-306904-8iteddug	777	18	tensin	tensin	NNP
cord-306904-8iteddug	777	19	homologue	homologue	NN
cord-306904-8iteddug	777	20	(	(	-LRB-
cord-306904-8iteddug	777	21	PTEN	PTEN	NNP
cord-306904-8iteddug	777	22	)	)	-RRB-
cord-306904-8iteddug	777	23	proteins	protein	NNS
cord-306904-8iteddug	777	24	with	with	IN
cord-306904-8iteddug	777	25	phosphatidylinositol	phosphatidylinositol	JJ
cord-306904-8iteddug	777	26	phosphates	phosphate	NNS
cord-306904-8iteddug	777	27	:	:	:
cord-306904-8iteddug	778	1	insights	insight	NNS
cord-306904-8iteddug	778	2	from	from	IN
cord-306904-8iteddug	778	3	molecular	molecular	JJ
cord-306904-8iteddug	778	4	dynamics	dynamic	NNS
cord-306904-8iteddug	778	5	simulations	simulation	NNS
cord-306904-8iteddug	778	6	of	of	IN
cord-306904-8iteddug	778	7	PTEN	PTEN	NNP
cord-306904-8iteddug	778	8	and	and	CC
cord-306904-8iteddug	778	9	voltage	voltage	VB
cord-306904-8iteddug	778	10	sensitive	sensitive	JJ
cord-306904-8iteddug	778	11	phosphatase	phosphatase	NN
cord-306904-8iteddug	778	12	The	the	DT
cord-306904-8iteddug	778	13	tumor	tumor	NN
cord-306904-8iteddug	778	14	suppressor	suppressor	NN
cord-306904-8iteddug	778	15	,	,	,
cord-306904-8iteddug	778	16	PTEN	PTEN	NNP
cord-306904-8iteddug	778	17	/	/	SYM
cord-306904-8iteddug	778	18	MMAC1	MMAC1	NNP
cord-306904-8iteddug	778	19	,	,	,
cord-306904-8iteddug	778	20	dephosphorylates	dephosphorylates	NNP
cord-306904-8iteddug	779	1	the	the	DT
cord-306904-8iteddug	779	2	lipid	lipid	NN
cord-306904-8iteddug	779	3	second	second	JJ
cord-306904-8iteddug	779	4	messenger	messenger	NN
cord-306904-8iteddug	779	5	,	,	,
cord-306904-8iteddug	779	6	phosphatidylinositol	phosphatidylinositol	JJ
cord-306904-8iteddug	779	7	3,4,5-trisphosphate	3,4,5-trisphosphate	CD
cord-306904-8iteddug	779	8	Intrinsic	intrinsic	JJ
cord-306904-8iteddug	779	9	disorder	disorder	NN
cord-306904-8iteddug	779	10	in	in	IN
cord-306904-8iteddug	779	11	PTEN	PTEN	NNP
cord-306904-8iteddug	779	12	and	and	CC
cord-306904-8iteddug	779	13	its	-PRON-	PRP$
cord-306904-8iteddug	779	14	interactome	interactome	NN
cord-306904-8iteddug	779	15	confers	confer	VBZ
cord-306904-8iteddug	779	16	structural	structural	JJ
cord-306904-8iteddug	779	17	plasticity	plasticity	NN
cord-306904-8iteddug	779	18	and	and	CC
cord-306904-8iteddug	779	19	functional	functional	JJ
cord-306904-8iteddug	779	20	versatility	versatility	NN
cord-306904-8iteddug	780	1	The	the	DT
cord-306904-8iteddug	780	2	PTEN	PTEN	NNP
cord-306904-8iteddug	780	3	Long	Long	NNP
cord-306904-8iteddug	780	4	N	n	CD
cord-306904-8iteddug	780	5	-	-	HYPH
cord-306904-8iteddug	780	6	tail	tail	NN
cord-306904-8iteddug	780	7	is	be	VBZ
cord-306904-8iteddug	780	8	intrinsically	intrinsically	RB
cord-306904-8iteddug	780	9	disordered	disordered	JJ
cord-306904-8iteddug	780	10	:	:	:
cord-306904-8iteddug	780	11	increased	increase	VBN
cord-306904-8iteddug	780	12	viability	viability	NN
cord-306904-8iteddug	780	13	for	for	IN
cord-306904-8iteddug	780	14	PTEN	PTEN	NNP
cord-306904-8iteddug	780	15	therapy	therapy	NN
cord-306904-8iteddug	780	16	Pathological	pathological	JJ
cord-306904-8iteddug	780	17	unfoldomics	unfoldomic	NNS
cord-306904-8iteddug	780	18	of	of	IN
cord-306904-8iteddug	780	19	uncontrolled	uncontrolled	JJ
cord-306904-8iteddug	780	20	chaos	chaos	NN
cord-306904-8iteddug	780	21	:	:	:
cord-306904-8iteddug	780	22	intrinsically	intrinsically	RB
cord-306904-8iteddug	780	23	disordered	disordered	JJ
cord-306904-8iteddug	780	24	proteins	protein	NNS
cord-306904-8iteddug	780	25	and	and	CC
cord-306904-8iteddug	780	26	human	human	JJ
cord-306904-8iteddug	780	27	diseases	disease	NNS
cord-306904-8iteddug	781	1	The	the	DT
cord-306904-8iteddug	781	2	structure	structure	NN
cord-306904-8iteddug	781	3	of	of	IN
cord-306904-8iteddug	781	4	Xis	Xis	NNP
cord-306904-8iteddug	781	5	reveals	reveal	VBZ
cord-306904-8iteddug	781	6	the	the	DT
cord-306904-8iteddug	781	7	basis	basis	NN
cord-306904-8iteddug	781	8	for	for	IN
cord-306904-8iteddug	781	9	filament	filament	NN
cord-306904-8iteddug	781	10	formation	formation	NN
cord-306904-8iteddug	781	11	and	and	CC
cord-306904-8iteddug	781	12	insight	insight	NN
cord-306904-8iteddug	781	13	into	into	IN
cord-306904-8iteddug	781	14	DNA	dna	NN
cord-306904-8iteddug	781	15	bending	bending	NN
cord-306904-8iteddug	781	16	within	within	IN
cord-306904-8iteddug	781	17	a	a	DT
cord-306904-8iteddug	781	18	mycobacteriophage	mycobacteriophage	NN
cord-306904-8iteddug	781	19	intasome	intasome	VBN
cord-306904-8iteddug	781	20	Determinants	determinant	NNS
cord-306904-8iteddug	781	21	of	of	IN
cord-306904-8iteddug	781	22	directionality	directionality	NN
cord-306904-8iteddug	781	23	in	in	IN
cord-306904-8iteddug	781	24	lambda	lambda	NN
cord-306904-8iteddug	781	25	site	site	NN
cord-306904-8iteddug	781	26	-	-	HYPH
cord-306904-8iteddug	781	27	specific	specific	JJ
cord-306904-8iteddug	781	28	recombination	recombination	NN
cord-306904-8iteddug	781	29	Control	control	NN
cord-306904-8iteddug	781	30	of	of	IN
cord-306904-8iteddug	781	31	directionality	directionality	NN
cord-306904-8iteddug	781	32	in	in	IN
cord-306904-8iteddug	781	33	L5	L5	NNP
cord-306904-8iteddug	781	34	integrase	integrase	NN
cord-306904-8iteddug	781	35	-	-	HYPH
cord-306904-8iteddug	781	36	mediated	mediate	VBN
cord-306904-8iteddug	781	37	site	site	NN
cord-306904-8iteddug	781	38	-	-	HYPH
cord-306904-8iteddug	781	39	specific	specific	JJ
cord-306904-8iteddug	781	40	recombination	recombination	NN
cord-306904-8iteddug	781	41	Identification	identification	NN
cord-306904-8iteddug	781	42	and	and	CC
cord-306904-8iteddug	781	43	characterization	characterization	NN
cord-306904-8iteddug	781	44	of	of	IN
cord-306904-8iteddug	781	45	mycobacteriophage	mycobacteriophage	NN
cord-306904-8iteddug	781	46	L5	L5	NNP
cord-306904-8iteddug	781	47	excisionase	excisionase	NNP
cord-306904-8iteddug	781	48	Structure	Structure	NNP
cord-306904-8iteddug	781	49	of	of	IN
cord-306904-8iteddug	781	50	the	the	DT
cord-306904-8iteddug	781	51	cooperative	cooperative	JJ
cord-306904-8iteddug	781	52	Xis	Xis	NNP
cord-306904-8iteddug	781	53	-	-	HYPH
cord-306904-8iteddug	781	54	DNA	DNA	NNP
cord-306904-8iteddug	781	55	complex	complex	NN
cord-306904-8iteddug	781	56	reveals	reveal	VBZ
cord-306904-8iteddug	781	57	a	a	DT
cord-306904-8iteddug	781	58	micronucleoprotein	micronucleoprotein	NNP
cord-306904-8iteddug	781	59	filament	filament	NN
cord-306904-8iteddug	781	60	that	that	WDT
cord-306904-8iteddug	781	61	regulates	regulate	VBZ
cord-306904-8iteddug	781	62	phage	phage	NN
cord-306904-8iteddug	781	63	lambda	lambda	NNP
cord-306904-8iteddug	781	64	intasome	intasome	NNP
cord-306904-8iteddug	781	65	assembly	assembly	NNP
cord-306904-8iteddug	781	66	Regulation	Regulation	NNP
cord-306904-8iteddug	781	67	of	of	IN
cord-306904-8iteddug	781	68	directionality	directionality	NN
cord-306904-8iteddug	781	69	in	in	IN
cord-306904-8iteddug	781	70	bacteriophage	bacteriophage	NN
cord-306904-8iteddug	781	71	lambda	lambda	NN
cord-306904-8iteddug	781	72	site	site	NN
cord-306904-8iteddug	781	73	-	-	HYPH
cord-306904-8iteddug	781	74	specific	specific	JJ
cord-306904-8iteddug	781	75	recombination	recombination	NN
cord-306904-8iteddug	781	76	:	:	:
cord-306904-8iteddug	781	77	structure	structure	NN
cord-306904-8iteddug	781	78	of	of	IN
cord-306904-8iteddug	781	79	the	the	DT
cord-306904-8iteddug	781	80	Xis	Xis	NNP
cord-306904-8iteddug	781	81	protein	protein	NN
cord-306904-8iteddug	781	82	Unique	unique	JJ
cord-306904-8iteddug	781	83	proline	proline	JJ
cord-306904-8iteddug	781	84	-	-	HYPH
cord-306904-8iteddug	781	85	rich	rich	JJ
cord-306904-8iteddug	781	86	domain	domain	NN
cord-306904-8iteddug	781	87	regulates	regulate	VBZ
cord-306904-8iteddug	781	88	the	the	DT
cord-306904-8iteddug	781	89	chaperone	chaperone	NN
cord-306904-8iteddug	781	90	function	function	NN
cord-306904-8iteddug	781	91	of	of	IN
cord-306904-8iteddug	781	92	AIPL1	AIPL1	NNP
cord-306904-8iteddug	781	93	Flexible	flexible	JJ
cord-306904-8iteddug	781	94	nets	net	NNS
cord-306904-8iteddug	781	95	of	of	IN
cord-306904-8iteddug	781	96	malleable	malleable	JJ
cord-306904-8iteddug	781	97	guardians	guardian	NNS
cord-306904-8iteddug	781	98	:	:	:
cord-306904-8iteddug	781	99	intrinsically	intrinsically	RB
cord-306904-8iteddug	781	100	disordered	disordered	JJ
cord-306904-8iteddug	781	101	chaperones	chaperone	NNS
cord-306904-8iteddug	781	102	in	in	IN
cord-306904-8iteddug	781	103	neurodegenerative	neurodegenerative	JJ
cord-306904-8iteddug	781	104	diseases	disease	NNS
cord-306904-8iteddug	782	1	Variable	variable	JJ
cord-306904-8iteddug	782	2	contributions	contribution	NNS
cord-306904-8iteddug	782	3	of	of	IN
cord-306904-8iteddug	782	4	basic	basic	JJ
cord-306904-8iteddug	782	5	residues	residue	NNS
cord-306904-8iteddug	782	6	forming	form	VBG
cord-306904-8iteddug	782	7	an	an	DT
cord-306904-8iteddug	782	8	APC	APC	NNP
cord-306904-8iteddug	782	9	exosite	exosite	NN
cord-306904-8iteddug	782	10	in	in	IN
cord-306904-8iteddug	782	11	the	the	DT
cord-306904-8iteddug	782	12	binding	binding	NN
cord-306904-8iteddug	782	13	and	and	CC
cord-306904-8iteddug	782	14	inactivation	inactivation	NN
cord-306904-8iteddug	782	15	of	of	IN
cord-306904-8iteddug	782	16	factor	factor	NN
cord-306904-8iteddug	782	17	VIIIa	VIIIa	VBZ
cord-306904-8iteddug	782	18	Molecular	molecular	JJ
cord-306904-8iteddug	782	19	events	event	NNS
cord-306904-8iteddug	782	20	that	that	WDT
cord-306904-8iteddug	782	21	control	control	VBP
cord-306904-8iteddug	782	22	the	the	DT
cord-306904-8iteddug	782	23	protein	protein	NN
cord-306904-8iteddug	782	24	C	C	NNP
cord-306904-8iteddug	782	25	anticoagulant	anticoagulant	NN
cord-306904-8iteddug	782	26	pathway	pathway	NN
cord-306904-8iteddug	782	27	Regulation	regulation	NN
cord-306904-8iteddug	782	28	of	of	IN
cord-306904-8iteddug	782	29	blood	blood	NN
cord-306904-8iteddug	782	30	coagulation	coagulation	NN
cord-306904-8iteddug	782	31	by	by	IN
cord-306904-8iteddug	782	32	the	the	DT
cord-306904-8iteddug	782	33	protein	protein	NN
cord-306904-8iteddug	782	34	C	c	NN
cord-306904-8iteddug	782	35	system	system	NN
cord-306904-8iteddug	783	1	The	the	DT
cord-306904-8iteddug	783	2	mechanism	mechanism	NN
cord-306904-8iteddug	783	3	of	of	IN
cord-306904-8iteddug	783	4	inactivation	inactivation	NN
cord-306904-8iteddug	783	5	of	of	IN
cord-306904-8iteddug	783	6	human	human	JJ
cord-306904-8iteddug	783	7	factor	factor	NN
cord-306904-8iteddug	783	8	V	v	NN
cord-306904-8iteddug	783	9	and	and	CC
cord-306904-8iteddug	783	10	human	human	JJ
cord-306904-8iteddug	783	11	factor	factor	NN
cord-306904-8iteddug	783	12	Va	Va	NNP
cord-306904-8iteddug	783	13	by	by	IN
cord-306904-8iteddug	783	14	activated	activate	VBN
cord-306904-8iteddug	783	15	protein	protein	NN
cord-306904-8iteddug	783	16	C	c	NN
cord-306904-8iteddug	784	1	The	the	DT
cord-306904-8iteddug	784	2	2.8	2.8	CD
cord-306904-8iteddug	784	3	A	a	DT
cord-306904-8iteddug	784	4	crystal	crystal	NN
cord-306904-8iteddug	784	5	structure	structure	NN
cord-306904-8iteddug	784	6	of	of	IN
cord-306904-8iteddug	784	7	Gla	Gla	NNP
cord-306904-8iteddug	784	8	-	-	HYPH
cord-306904-8iteddug	784	9	domainless	domainless	NN
cord-306904-8iteddug	784	10	activated	activate	VBD
cord-306904-8iteddug	784	11	protein	protein	NN
cord-306904-8iteddug	784	12	C	C	NNP
cord-306904-8iteddug	784	13	The	the	DT
cord-306904-8iteddug	784	14	Escherichia	Escherichia	NNP
cord-306904-8iteddug	784	15	coli	coli	NNS
cord-306904-8iteddug	784	16	primosomal	primosomal	VBN
cord-306904-8iteddug	784	17	DnaT	DnaT	NNP
cord-306904-8iteddug	784	18	protein	protein	NN
cord-306904-8iteddug	784	19	exists	exist	VBZ
cord-306904-8iteddug	784	20	in	in	IN
cord-306904-8iteddug	784	21	solution	solution	NN
cord-306904-8iteddug	784	22	as	as	IN
cord-306904-8iteddug	784	23	a	a	DT
cord-306904-8iteddug	784	24	monomer	monomer	NN
cord-306904-8iteddug	784	25	-	-	HYPH
cord-306904-8iteddug	784	26	trimer	trimer	NN
cord-306904-8iteddug	784	27	equilibrium	equilibrium	NN
cord-306904-8iteddug	784	28	system	system	NN
cord-306904-8iteddug	784	29	Assembly	Assembly	NNP
cord-306904-8iteddug	784	30	of	of	IN
cord-306904-8iteddug	784	31	the	the	DT
cord-306904-8iteddug	784	32	primosome	primosome	NN
cord-306904-8iteddug	784	33	of	of	IN
cord-306904-8iteddug	784	34	DNA	dna	NN
cord-306904-8iteddug	784	35	replication	replication	NN
cord-306904-8iteddug	784	36	in	in	IN
cord-306904-8iteddug	784	37	Escherichia	Escherichia	NNP
cord-306904-8iteddug	784	38	coli	coli	VBZ
cord-306904-8iteddug	784	39	Requirements	requirement	NNS
cord-306904-8iteddug	784	40	for	for	IN
cord-306904-8iteddug	784	41	replication	replication	NN
cord-306904-8iteddug	784	42	restart	restart	NN
cord-306904-8iteddug	784	43	proteins	protein	NNS
cord-306904-8iteddug	784	44	during	during	IN
cord-306904-8iteddug	784	45	constitutive	constitutive	JJ
cord-306904-8iteddug	784	46	stable	stable	JJ
cord-306904-8iteddug	784	47	DNA	dna	NN
cord-306904-8iteddug	784	48	replication	replication	NN
cord-306904-8iteddug	784	49	in	in	IN
cord-306904-8iteddug	784	50	Escherichia	Escherichia	NNP
cord-306904-8iteddug	784	51	coli	coli	VBZ
cord-306904-8iteddug	784	52	K-12	K-12	NNP
cord-306904-8iteddug	784	53	Replication	Replication	NNP
cord-306904-8iteddug	784	54	fork	fork	NN
cord-306904-8iteddug	784	55	reactivation	reactivation	NN
cord-306904-8iteddug	784	56	downstream	downstream	RB
cord-306904-8iteddug	784	57	of	of	IN
cord-306904-8iteddug	784	58	a	a	DT
cord-306904-8iteddug	784	59	blocked	block	VBN
cord-306904-8iteddug	784	60	nascent	nascent	JJ
cord-306904-8iteddug	784	61	leading	leading	NN
cord-306904-8iteddug	784	62	strand	strand	NN
cord-306904-8iteddug	785	1	The	the	DT
cord-306904-8iteddug	785	2	most	most	RBS
cord-306904-8iteddug	785	3	important	important	JJ
cord-306904-8iteddug	785	4	thing	thing	NN
cord-306904-8iteddug	785	5	is	be	VBZ
cord-306904-8iteddug	785	6	the	the	DT
cord-306904-8iteddug	785	7	tail	tail	NN
cord-306904-8iteddug	785	8	:	:	:
cord-306904-8iteddug	785	9	multitudinous	multitudinous	JJ
cord-306904-8iteddug	785	10	functionalities	functionality	NNS
cord-306904-8iteddug	785	11	of	of	IN
cord-306904-8iteddug	785	12	intrinsically	intrinsically	RB
cord-306904-8iteddug	785	13	disordered	disordered	JJ
cord-306904-8iteddug	785	14	protein	protein	NN
cord-306904-8iteddug	785	15	termini	termini	NN
cord-306904-8iteddug	785	16	Immunoreceptor	Immunoreceptor	NNP
cord-306904-8iteddug	785	17	tyrosine	tyrosine	NN
cord-306904-8iteddug	785	18	-	-	HYPH
cord-306904-8iteddug	785	19	based	base	VBN
cord-306904-8iteddug	785	20	inhibitory	inhibitory	JJ
cord-306904-8iteddug	785	21	motif	motif	NN
cord-306904-8iteddug	785	22	(	(	-LRB-
cord-306904-8iteddug	785	23	ITIM)-mediated	itim)-mediate	VBN
cord-306904-8iteddug	785	24	inhibitory	inhibitory	JJ
cord-306904-8iteddug	785	25	signaling	signaling	NN
cord-306904-8iteddug	785	26	is	be	VBZ
cord-306904-8iteddug	785	27	regulated	regulate	VBN
cord-306904-8iteddug	785	28	by	by	IN
cord-306904-8iteddug	785	29	sequential	sequential	JJ
cord-306904-8iteddug	785	30	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	785	31	mediated	mediate	VBN
cord-306904-8iteddug	785	32	by	by	IN
cord-306904-8iteddug	785	33	distinct	distinct	JJ
cord-306904-8iteddug	785	34	nonreceptor	nonreceptor	NN
cord-306904-8iteddug	785	35	tyrosine	tyrosine	NN
cord-306904-8iteddug	785	36	kinases	kinase	NNS
cord-306904-8iteddug	785	37	:	:	:
cord-306904-8iteddug	785	38	a	a	DT
cord-306904-8iteddug	785	39	case	case	NN
cord-306904-8iteddug	785	40	study	study	NN
cord-306904-8iteddug	785	41	involving	involve	VBG
cord-306904-8iteddug	785	42	PECAM-1	PECAM-1	NNP
cord-306904-8iteddug	785	43	Signal	Signal	NNP
cord-306904-8iteddug	785	44	transduction	transduction	NN
cord-306904-8iteddug	785	45	pathways	pathway	NNS
cord-306904-8iteddug	785	46	mediated	mediate	VBN
cord-306904-8iteddug	785	47	by	by	IN
cord-306904-8iteddug	785	48	PECAM-1	PECAM-1	NNP
cord-306904-8iteddug	785	49	:	:	:
cord-306904-8iteddug	785	50	new	new	JJ
cord-306904-8iteddug	785	51	roles	role	NNS
cord-306904-8iteddug	785	52	for	for	IN
cord-306904-8iteddug	785	53	an	an	DT
cord-306904-8iteddug	785	54	old	old	JJ
cord-306904-8iteddug	785	55	molecule	molecule	NN
cord-306904-8iteddug	785	56	in	in	IN
cord-306904-8iteddug	785	57	platelet	platelet	NN
cord-306904-8iteddug	785	58	and	and	CC
cord-306904-8iteddug	785	59	vascular	vascular	JJ
cord-306904-8iteddug	785	60	cell	cell	NN
cord-306904-8iteddug	785	61	biology	biology	NN
cord-306904-8iteddug	785	62	Residues	residue	NNS
cord-306904-8iteddug	785	63	within	within	IN
cord-306904-8iteddug	785	64	a	a	DT
cord-306904-8iteddug	785	65	lipid	lipid	NN
cord-306904-8iteddug	785	66	-	-	HYPH
cord-306904-8iteddug	785	67	associated	associate	VBN
cord-306904-8iteddug	785	68	segment	segment	NN
cord-306904-8iteddug	785	69	of	of	IN
cord-306904-8iteddug	785	70	the	the	DT
cord-306904-8iteddug	785	71	PECAM-1	pecam-1	JJ
cord-306904-8iteddug	785	72	cytoplasmic	cytoplasmic	JJ
cord-306904-8iteddug	785	73	domain	domain	NN
cord-306904-8iteddug	785	74	are	be	VBP
cord-306904-8iteddug	785	75	susceptible	susceptible	JJ
cord-306904-8iteddug	785	76	to	to	IN
cord-306904-8iteddug	785	77	inducible	inducible	JJ
cord-306904-8iteddug	785	78	,	,	,
cord-306904-8iteddug	785	79	sequential	sequential	JJ
cord-306904-8iteddug	785	80	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	785	81	Splicing	splicing	NN
cord-306904-8iteddug	785	82	kinase	kinase	NN
cord-306904-8iteddug	785	83	SRPK1	srpk1	NN
cord-306904-8iteddug	785	84	conforms	conform	VBZ
cord-306904-8iteddug	785	85	to	to	IN
cord-306904-8iteddug	785	86	the	the	DT
cord-306904-8iteddug	785	87	landscape	landscape	NN
cord-306904-8iteddug	785	88	of	of	IN
cord-306904-8iteddug	785	89	its	-PRON-	PRP$
cord-306904-8iteddug	785	90	SR	SR	NNP
cord-306904-8iteddug	785	91	protein	protein	NN
cord-306904-8iteddug	785	92	substrate	substrate	NN
cord-306904-8iteddug	785	93	Intrinsic	intrinsic	JJ
cord-306904-8iteddug	785	94	disorder	disorder	NN
cord-306904-8iteddug	785	95	in	in	IN
cord-306904-8iteddug	785	96	the	the	DT
cord-306904-8iteddug	785	97	human	human	JJ
cord-306904-8iteddug	785	98	spliceosomal	spliceosomal	NNP
cord-306904-8iteddug	785	99	proteome	proteome	NNP
cord-306904-8iteddug	785	100	Malleable	malleable	JJ
cord-306904-8iteddug	785	101	ribonucleoprotein	ribonucleoprotein	NN
cord-306904-8iteddug	785	102	machine	machine	NN
cord-306904-8iteddug	785	103	:	:	:
cord-306904-8iteddug	785	104	protein	protein	NN
cord-306904-8iteddug	785	105	intrinsic	intrinsic	JJ
cord-306904-8iteddug	785	106	disorder	disorder	NN
cord-306904-8iteddug	785	107	in	in	IN
cord-306904-8iteddug	785	108	the	the	DT
cord-306904-8iteddug	785	109	Saccharomyces	Saccharomyces	NNP
cord-306904-8iteddug	785	110	cerevisiae	cerevisiae	VBZ
cord-306904-8iteddug	785	111	spliceosome	spliceosome	NNP
cord-306904-8iteddug	785	112	IFITMs	ifitm	NNS
cord-306904-8iteddug	785	113	restrict	restrict	VBP
cord-306904-8iteddug	785	114	the	the	DT
cord-306904-8iteddug	785	115	replication	replication	NN
cord-306904-8iteddug	785	116	of	of	IN
cord-306904-8iteddug	785	117	multiple	multiple	JJ
cord-306904-8iteddug	785	118	pathogenic	pathogenic	JJ
cord-306904-8iteddug	785	119	viruses	virus	NNS
cord-306904-8iteddug	786	1	The	the	DT
cord-306904-8iteddug	786	2	IFITM	IFITM	NNP
cord-306904-8iteddug	786	3	proteins	protein	NNS
cord-306904-8iteddug	786	4	mediate	mediate	VBP
cord-306904-8iteddug	786	5	cellular	cellular	JJ
cord-306904-8iteddug	786	6	resistance	resistance	NN
cord-306904-8iteddug	786	7	to	to	TO
cord-306904-8iteddug	786	8	influenza	influenza	VB
cord-306904-8iteddug	786	9	A	a	DT
cord-306904-8iteddug	786	10	H1N1	H1N1	NNP
cord-306904-8iteddug	786	11	virus	virus	NN
cord-306904-8iteddug	786	12	,	,	,
cord-306904-8iteddug	786	13	West	West	NNP
cord-306904-8iteddug	786	14	Nile	Nile	NNP
cord-306904-8iteddug	786	15	virus	virus	NN
cord-306904-8iteddug	786	16	,	,	,
cord-306904-8iteddug	786	17	and	and	CC
cord-306904-8iteddug	786	18	dengue	dengue	NN
cord-306904-8iteddug	786	19	virus	virus	NN
cord-306904-8iteddug	787	1	Distinct	distinct	JJ
cord-306904-8iteddug	787	2	patterns	pattern	NNS
cord-306904-8iteddug	787	3	of	of	IN
cord-306904-8iteddug	787	4	IFITM	ifitm	NN
cord-306904-8iteddug	787	5	-	-	HYPH
cord-306904-8iteddug	787	6	mediated	mediate	VBN
cord-306904-8iteddug	787	7	restriction	restriction	NN
cord-306904-8iteddug	787	8	of	of	IN
cord-306904-8iteddug	787	9	filoviruses	filovirus	NNS
cord-306904-8iteddug	787	10	,	,	,
cord-306904-8iteddug	787	11	SARS	SARS	NNP
cord-306904-8iteddug	787	12	coronavirus	coronavirus	NN
cord-306904-8iteddug	787	13	,	,	,
cord-306904-8iteddug	787	14	and	and	CC
cord-306904-8iteddug	787	15	influenza	influenza	NN
cord-306904-8iteddug	787	16	A	a	DT
cord-306904-8iteddug	787	17	virus	virus	NN
cord-306904-8iteddug	788	1	IFITM1	IFITM1	NNP
cord-306904-8iteddug	788	2	is	be	VBZ
cord-306904-8iteddug	788	3	a	a	DT
cord-306904-8iteddug	788	4	tight	tight	JJ
cord-306904-8iteddug	788	5	junction	junction	NN
cord-306904-8iteddug	788	6	protein	protein	NN
cord-306904-8iteddug	788	7	that	that	WDT
cord-306904-8iteddug	788	8	inhibits	inhibit	VBZ
cord-306904-8iteddug	788	9	hepatitis	hepatitis	NN
cord-306904-8iteddug	788	10	C	C	NNP
cord-306904-8iteddug	788	11	virus	virus	NN
cord-306904-8iteddug	788	12	entry	entry	NN
cord-306904-8iteddug	788	13	Mechanism	Mechanism	NNP
cord-306904-8iteddug	788	14	of	of	IN
cord-306904-8iteddug	788	15	membrane	membrane	NN
cord-306904-8iteddug	788	16	fusion	fusion	NN
cord-306904-8iteddug	788	17	by	by	IN
cord-306904-8iteddug	788	18	viral	viral	JJ
cord-306904-8iteddug	788	19	envelope	envelope	NN
cord-306904-8iteddug	788	20	proteins	protein	NNS
cord-306904-8iteddug	788	21	IFITM3	IFITM3	''
cord-306904-8iteddug	789	1	inhibits	inhibit	VBZ
cord-306904-8iteddug	789	2	influenza	influenza	NN
cord-306904-8iteddug	789	3	A	a	DT
cord-306904-8iteddug	789	4	virus	virus	NN
cord-306904-8iteddug	789	5	infection	infection	NN
cord-306904-8iteddug	789	6	by	by	IN
cord-306904-8iteddug	789	7	preventing	prevent	VBG
cord-306904-8iteddug	789	8	cytosolic	cytosolic	JJ
cord-306904-8iteddug	789	9	entry	entry	NN
cord-306904-8iteddug	789	10	Predicting	predict	VBG
cord-306904-8iteddug	789	11	disordered	disordered	JJ
cord-306904-8iteddug	789	12	regions	region	NNS
cord-306904-8iteddug	789	13	from	from	IN
cord-306904-8iteddug	789	14	amino	amino	NN
cord-306904-8iteddug	789	15	acid	acid	NN
cord-306904-8iteddug	789	16	sequence	sequence	NN
cord-306904-8iteddug	789	17	:	:	:
cord-306904-8iteddug	790	1	common	common	JJ
cord-306904-8iteddug	790	2	themes	theme	NNS
cord-306904-8iteddug	790	3	despite	despite	IN
cord-306904-8iteddug	790	4	differing	differ	VBG
cord-306904-8iteddug	790	5	structural	structural	JJ
cord-306904-8iteddug	790	6	characterization	characterization	NN
cord-306904-8iteddug	790	7	Predicting	predict	VBG
cord-306904-8iteddug	790	8	binding	bind	VBG
cord-306904-8iteddug	790	9	regions	region	NNS
cord-306904-8iteddug	790	10	within	within	IN
cord-306904-8iteddug	790	11	disordered	disordered	JJ
cord-306904-8iteddug	790	12	proteins	protein	NNS
cord-306904-8iteddug	791	1	Coupled	coupled	JJ
cord-306904-8iteddug	791	2	folding	folding	NN
cord-306904-8iteddug	791	3	and	and	CC
cord-306904-8iteddug	791	4	binding	bind	VBG
cord-306904-8iteddug	791	5	with	with	IN
cord-306904-8iteddug	791	6	alpha	alpha	NN
cord-306904-8iteddug	791	7	-	-	HYPH
cord-306904-8iteddug	791	8	helix	helix	NN
cord-306904-8iteddug	791	9	-	-	HYPH
cord-306904-8iteddug	791	10	forming	form	VBG
cord-306904-8iteddug	791	11	molecular	molecular	JJ
cord-306904-8iteddug	791	12	recognition	recognition	NN
cord-306904-8iteddug	791	13	elements	element	NNS
cord-306904-8iteddug	791	14	Analysis	Analysis	NNP
cord-306904-8iteddug	791	15	of	of	IN
cord-306904-8iteddug	791	16	molecular	molecular	JJ
cord-306904-8iteddug	791	17	recognition	recognition	NN
cord-306904-8iteddug	791	18	features	feature	NNS
cord-306904-8iteddug	791	19	(	(	-LRB-
cord-306904-8iteddug	791	20	MoRFs	MoRFs	NNP
cord-306904-8iteddug	792	1	)	)	-RRB-
cord-306904-8iteddug	792	2	Mining	mining	NN
cord-306904-8iteddug	792	3	alpha	alpha	NN
cord-306904-8iteddug	792	4	-	-	HYPH
cord-306904-8iteddug	792	5	helix	helix	NN
cord-306904-8iteddug	792	6	-	-	HYPH
cord-306904-8iteddug	792	7	forming	form	VBG
cord-306904-8iteddug	792	8	molecular	molecular	JJ
cord-306904-8iteddug	792	9	recognition	recognition	NN
cord-306904-8iteddug	792	10	features	feature	NNS
cord-306904-8iteddug	792	11	with	with	IN
cord-306904-8iteddug	792	12	cross	cross	NN
cord-306904-8iteddug	792	13	species	species	NN
cord-306904-8iteddug	792	14	sequence	sequence	NN
cord-306904-8iteddug	792	15	alignments	alignment	NNS
cord-306904-8iteddug	793	1	Type	type	NN
cord-306904-8iteddug	793	2	2	2	CD
cord-306904-8iteddug	793	3	ryanodine	ryanodine	JJ
cord-306904-8iteddug	793	4	receptor	receptor	NN
cord-306904-8iteddug	793	5	domain	domain	NN
cord-306904-8iteddug	793	6	A	A	NNP
cord-306904-8iteddug	793	7	contains	contain	VBZ
cord-306904-8iteddug	793	8	a	a	DT
cord-306904-8iteddug	793	9	unique	unique	JJ
cord-306904-8iteddug	793	10	and	and	CC
cord-306904-8iteddug	793	11	dynamic	dynamic	JJ
cord-306904-8iteddug	793	12	alpha	alpha	NN
cord-306904-8iteddug	793	13	-	-	HYPH
cord-306904-8iteddug	793	14	helix	helix	NN
cord-306904-8iteddug	793	15	that	that	WDT
cord-306904-8iteddug	793	16	transitions	transition	VBZ
cord-306904-8iteddug	793	17	to	to	IN
cord-306904-8iteddug	793	18	a	a	DT
cord-306904-8iteddug	793	19	beta	beta	JJ
cord-306904-8iteddug	793	20	-	-	HYPH
cord-306904-8iteddug	793	21	strand	strand	NN
cord-306904-8iteddug	793	22	in	in	IN
cord-306904-8iteddug	793	23	a	a	DT
cord-306904-8iteddug	793	24	mutant	mutant	NN
cord-306904-8iteddug	793	25	linked	link	VBN
cord-306904-8iteddug	793	26	with	with	IN
cord-306904-8iteddug	793	27	a	a	DT
cord-306904-8iteddug	793	28	heritable	heritable	JJ
cord-306904-8iteddug	793	29	cardiomyopathy	cardiomyopathy	NN
cord-306904-8iteddug	793	30	Involvement	Involvement	NNP
cord-306904-8iteddug	793	31	of	of	IN
cord-306904-8iteddug	793	32	dihydropyridine	dihydropyridine	NN
cord-306904-8iteddug	793	33	receptors	receptor	NNS
cord-306904-8iteddug	793	34	in	in	IN
cord-306904-8iteddug	793	35	excitation	excitation	NN
cord-306904-8iteddug	793	36	-	-	HYPH
cord-306904-8iteddug	793	37	contraction	contraction	NN
cord-306904-8iteddug	793	38	coupling	coupling	NN
cord-306904-8iteddug	793	39	in	in	IN
cord-306904-8iteddug	793	40	skeletal	skeletal	JJ
cord-306904-8iteddug	793	41	muscle	muscle	NN
cord-306904-8iteddug	793	42	Interactions	interaction	NNS
cord-306904-8iteddug	793	43	between	between	IN
cord-306904-8iteddug	793	44	dihydropyridine	dihydropyridine	NN
cord-306904-8iteddug	793	45	receptors	receptor	NNS
cord-306904-8iteddug	793	46	and	and	CC
cord-306904-8iteddug	793	47	ryanodine	ryanodine	JJ
cord-306904-8iteddug	793	48	receptors	receptor	NNS
cord-306904-8iteddug	793	49	in	in	IN
cord-306904-8iteddug	793	50	striated	striated	JJ
cord-306904-8iteddug	793	51	muscle	muscle	NN
cord-306904-8iteddug	793	52	Crystal	Crystal	NNP
cord-306904-8iteddug	793	53	structures	structure	NNS
cord-306904-8iteddug	793	54	of	of	IN
cord-306904-8iteddug	793	55	the	the	DT
cord-306904-8iteddug	793	56	Nterminal	Nterminal	NNP
cord-306904-8iteddug	793	57	domains	domain	NNS
cord-306904-8iteddug	793	58	of	of	IN
cord-306904-8iteddug	793	59	cardiac	cardiac	JJ
cord-306904-8iteddug	793	60	and	and	CC
cord-306904-8iteddug	793	61	skeletal	skeletal	JJ
cord-306904-8iteddug	793	62	muscle	muscle	NN
cord-306904-8iteddug	793	63	ryanodine	ryanodine	JJ
cord-306904-8iteddug	793	64	receptors	receptor	NNS
cord-306904-8iteddug	793	65	:	:	:
cord-306904-8iteddug	793	66	insights	insight	NNS
cord-306904-8iteddug	793	67	into	into	IN
cord-306904-8iteddug	793	68	disease	disease	NN
cord-306904-8iteddug	793	69	mutations	mutation	NNS
cord-306904-8iteddug	793	70	Van	Van	NNP
cord-306904-8iteddug	793	71	Petegem	Petegem	NNP
cord-306904-8iteddug	793	72	F.	F.	NNP
cord-306904-8iteddug	794	1	The	the	DT
cord-306904-8iteddug	794	2	deletion	deletion	NN
cord-306904-8iteddug	794	3	of	of	IN
cord-306904-8iteddug	794	4	exon	exon	NN
cord-306904-8iteddug	794	5	3	3	CD
cord-306904-8iteddug	794	6	in	in	IN
cord-306904-8iteddug	794	7	the	the	DT
cord-306904-8iteddug	794	8	cardiac	cardiac	JJ
cord-306904-8iteddug	794	9	ryanodine	ryanodine	JJ
cord-306904-8iteddug	794	10	receptor	receptor	NN
cord-306904-8iteddug	794	11	is	be	VBZ
cord-306904-8iteddug	794	12	rescued	rescue	VBN
cord-306904-8iteddug	794	13	by	by	IN
cord-306904-8iteddug	794	14	beta	beta	NN
cord-306904-8iteddug	794	15	strand	strand	NN
cord-306904-8iteddug	794	16	switching	switch	VBG
cord-306904-8iteddug	794	17	ATPinduced	atpinduced	JJ
cord-306904-8iteddug	794	18	dimerization	dimerization	NN
cord-306904-8iteddug	794	19	of	of	IN
cord-306904-8iteddug	794	20	the	the	DT
cord-306904-8iteddug	794	21	FF	FF	NNP
cord-306904-8iteddug	794	22	epsilon	epsilon	NN
cord-306904-8iteddug	794	23	subunit	subunit	NN
cord-306904-8iteddug	794	24	from	from	IN
cord-306904-8iteddug	794	25	Bacillus	Bacillus	NNP
cord-306904-8iteddug	794	26	PS3	PS3	NNP
cord-306904-8iteddug	794	27	:	:	:
cord-306904-8iteddug	794	28	a	a	DT
cord-306904-8iteddug	794	29	hydrogen	hydrogen	NN
cord-306904-8iteddug	794	30	exchange	exchange	NN
cord-306904-8iteddug	794	31	-	-	HYPH
cord-306904-8iteddug	794	32	mass	mass	NN
cord-306904-8iteddug	794	33	spectrometry	spectrometry	NN
cord-306904-8iteddug	794	34	study	study	NN
cord-306904-8iteddug	794	35	Crystal	Crystal	NNP
cord-306904-8iteddug	794	36	structure	structure	NN
cord-306904-8iteddug	794	37	of	of	IN
cord-306904-8iteddug	794	38	the	the	DT
cord-306904-8iteddug	794	39	epsilon	epsilon	NN
cord-306904-8iteddug	794	40	subunit	subunit	NN
cord-306904-8iteddug	794	41	of	of	IN
cord-306904-8iteddug	794	42	the	the	DT
cord-306904-8iteddug	794	43	proton	proton	NN
cord-306904-8iteddug	794	44	-	-	HYPH
cord-306904-8iteddug	794	45	translocating	translocate	VBG
cord-306904-8iteddug	794	46	ATP	ATP	NNP
cord-306904-8iteddug	794	47	synthase	synthase	NN
cord-306904-8iteddug	794	48	from	from	IN
cord-306904-8iteddug	794	49	Escherichia	Escherichia	NNP
cord-306904-8iteddug	794	50	coli	coli	VBZ
cord-306904-8iteddug	794	51	Phosphorylation	Phosphorylation	NNP
cord-306904-8iteddug	794	52	of	of	IN
cord-306904-8iteddug	794	53	the	the	DT
cord-306904-8iteddug	794	54	cyclin	cyclin	NN
cord-306904-8iteddug	794	55	CaPcl5	capcl5	NN
cord-306904-8iteddug	794	56	modulates	modulate	VBZ
cord-306904-8iteddug	794	57	both	both	DT
cord-306904-8iteddug	794	58	cyclin	cyclin	JJ
cord-306904-8iteddug	794	59	stability	stability	NN
cord-306904-8iteddug	794	60	and	and	CC
cord-306904-8iteddug	794	61	specific	specific	JJ
cord-306904-8iteddug	794	62	recognition	recognition	NN
cord-306904-8iteddug	794	63	of	of	IN
cord-306904-8iteddug	794	64	the	the	DT
cord-306904-8iteddug	794	65	substrate	substrate	JJ
cord-306904-8iteddug	794	66	Principles	Principles	NNPS
cord-306904-8iteddug	794	67	of	of	IN
cord-306904-8iteddug	794	68	CDK	CDK	NNP
cord-306904-8iteddug	794	69	regulation	regulation	NN
cord-306904-8iteddug	794	70	Cyclin	Cyclin	NNP
cord-306904-8iteddug	794	71	specificity	specificity	NN
cord-306904-8iteddug	794	72	:	:	:
cord-306904-8iteddug	794	73	how	how	WRB
cord-306904-8iteddug	794	74	many	many	JJ
cord-306904-8iteddug	794	75	wheels	wheel	NNS
cord-306904-8iteddug	794	76	do	do	VBP
cord-306904-8iteddug	794	77	you	-PRON-	PRP
cord-306904-8iteddug	794	78	need	need	VB
cord-306904-8iteddug	794	79	on	on	IN
cord-306904-8iteddug	794	80	a	a	DT
cord-306904-8iteddug	794	81	unicycle	unicycle	NN
cord-306904-8iteddug	794	82	?	?	.
cord-306904-8iteddug	795	1	A	a	DT
cord-306904-8iteddug	795	2	family	family	NN
cord-306904-8iteddug	795	3	of	of	IN
cord-306904-8iteddug	795	4	cyclin	cyclin	NN
cord-306904-8iteddug	795	5	-	-	HYPH
cord-306904-8iteddug	795	6	like	like	JJ
cord-306904-8iteddug	795	7	proteins	protein	NNS
cord-306904-8iteddug	795	8	that	that	WDT
cord-306904-8iteddug	795	9	interact	interact	VBP
cord-306904-8iteddug	795	10	with	with	IN
cord-306904-8iteddug	795	11	the	the	DT
cord-306904-8iteddug	795	12	Pho85	Pho85	NNP
cord-306904-8iteddug	795	13	cyclin	cyclin	NN
cord-306904-8iteddug	795	14	-	-	HYPH
cord-306904-8iteddug	795	15	dependent	dependent	JJ
cord-306904-8iteddug	795	16	kinase	kinase	NN
cord-306904-8iteddug	795	17	Regulation	regulation	NN
cord-306904-8iteddug	795	18	of	of	IN
cord-306904-8iteddug	795	19	the	the	DT
cord-306904-8iteddug	795	20	transcription	transcription	NN
cord-306904-8iteddug	795	21	factor	factor	NN
cord-306904-8iteddug	795	22	Gcn4	Gcn4	NNP
cord-306904-8iteddug	795	23	by	by	IN
cord-306904-8iteddug	795	24	Pho85	Pho85	NNP
cord-306904-8iteddug	796	1	cyclin	cyclin	NNP
cord-306904-8iteddug	796	2	PCL5	PCL5	NNP
cord-306904-8iteddug	796	3	Coevolution	Coevolution	NNP
cord-306904-8iteddug	796	4	of	of	IN
cord-306904-8iteddug	796	5	cyclin	cyclin	NN
cord-306904-8iteddug	796	6	Pcl5	Pcl5	NNP
cord-306904-8iteddug	796	7	and	and	CC
cord-306904-8iteddug	796	8	its	-PRON-	PRP$
cord-306904-8iteddug	796	9	substrate	substrate	NN
cord-306904-8iteddug	796	10	Gcn4	Gcn4	NNP
cord-306904-8iteddug	797	1	Understanding	understand	VBG
cord-306904-8iteddug	797	2	protein	protein	NN
cord-306904-8iteddug	797	3	non	non	JJ
cord-306904-8iteddug	797	4	-	-	JJ
cord-306904-8iteddug	797	5	folding	folding	JJ
cord-306904-8iteddug	797	6	Constitutive	constitutive	JJ
cord-306904-8iteddug	797	7	nuclear	nuclear	JJ
cord-306904-8iteddug	797	8	localization	localization	NN
cord-306904-8iteddug	797	9	of	of	IN
cord-306904-8iteddug	797	10	an	an	DT
cord-306904-8iteddug	797	11	alternatively	alternatively	RB
cord-306904-8iteddug	797	12	spliced	splice	VBN
cord-306904-8iteddug	797	13	sirtuin-2	sirtuin-2	NNP
cord-306904-8iteddug	797	14	isoform	isoform	NN
cord-306904-8iteddug	797	15	Crosstalk	crosstalk	NN
cord-306904-8iteddug	797	16	between	between	IN
cord-306904-8iteddug	797	17	components	component	NNS
cord-306904-8iteddug	797	18	of	of	IN
cord-306904-8iteddug	797	19	circadian	circadian	NN
cord-306904-8iteddug	797	20	and	and	CC
cord-306904-8iteddug	797	21	metabolic	metabolic	JJ
cord-306904-8iteddug	797	22	cycles	cycle	NNS
cord-306904-8iteddug	797	23	in	in	IN
cord-306904-8iteddug	797	24	mammals	mammal	NNS
cord-306904-8iteddug	797	25	Sirtuins	Sirtuins	NNP
cord-306904-8iteddug	797	26	as	as	IN
cord-306904-8iteddug	797	27	regulators	regulator	NNS
cord-306904-8iteddug	797	28	of	of	IN
cord-306904-8iteddug	797	29	metabolism	metabolism	NN
cord-306904-8iteddug	797	30	and	and	CC
cord-306904-8iteddug	797	31	healthspan	healthspan	NNP
cord-306904-8iteddug	798	1	SIRT2	SIRT2	NNP
cord-306904-8iteddug	798	2	maintains	maintain	VBZ
cord-306904-8iteddug	798	3	genome	genome	NN
cord-306904-8iteddug	798	4	integrity	integrity	NN
cord-306904-8iteddug	798	5	and	and	CC
cord-306904-8iteddug	798	6	suppresses	suppress	VBZ
cord-306904-8iteddug	798	7	tumorigenesis	tumorigenesis	NN
cord-306904-8iteddug	798	8	through	through	IN
cord-306904-8iteddug	798	9	regulating	regulate	VBG
cord-306904-8iteddug	798	10	APC	APC	NNP
cord-306904-8iteddug	798	11	/	/	SYM
cord-306904-8iteddug	798	12	C	c	NN
cord-306904-8iteddug	798	13	activity	activity	NN
cord-306904-8iteddug	799	1	The	the	DT
cord-306904-8iteddug	799	2	mammalian	mammalian	JJ
cord-306904-8iteddug	799	3	SIR2alpha	SIR2alpha	NNP
cord-306904-8iteddug	799	4	protein	protein	NN
cord-306904-8iteddug	799	5	has	have	VBZ
cord-306904-8iteddug	799	6	a	a	DT
cord-306904-8iteddug	799	7	role	role	NN
cord-306904-8iteddug	799	8	in	in	IN
cord-306904-8iteddug	799	9	embryogenesis	embryogenesis	NN
cord-306904-8iteddug	799	10	and	and	CC
cord-306904-8iteddug	799	11	gametogenesis	gametogenesis	NN
cord-306904-8iteddug	799	12	The	the	DT
cord-306904-8iteddug	799	13	conserved	conserved	JJ
cord-306904-8iteddug	799	14	role	role	NN
cord-306904-8iteddug	799	15	of	of	IN
cord-306904-8iteddug	799	16	sirtuins	sirtuin	NNS
cord-306904-8iteddug	799	17	in	in	IN
cord-306904-8iteddug	799	18	chromatin	chromatin	NN
cord-306904-8iteddug	799	19	regulation	regulation	NN
cord-306904-8iteddug	800	1	Impaired	impaired	JJ
cord-306904-8iteddug	800	2	DNA	dna	NN
cord-306904-8iteddug	800	3	damage	damage	NN
cord-306904-8iteddug	800	4	response	response	NN
cord-306904-8iteddug	800	5	,	,	,
cord-306904-8iteddug	800	6	genome	genome	NN
cord-306904-8iteddug	800	7	instability	instability	NN
cord-306904-8iteddug	800	8	,	,	,
cord-306904-8iteddug	800	9	and	and	CC
cord-306904-8iteddug	800	10	tumorigenesis	tumorigenesis	NN
cord-306904-8iteddug	800	11	in	in	IN
cord-306904-8iteddug	800	12	SIRT1	sirt1	NN
cord-306904-8iteddug	800	13	mutant	mutant	JJ
cord-306904-8iteddug	800	14	mice	mouse	NNS
cord-306904-8iteddug	800	15	Regulation	Regulation	NNP
cord-306904-8iteddug	800	16	of	of	IN
cord-306904-8iteddug	800	17	sirtuin	sirtuin	NNP
cord-306904-8iteddug	800	18	function	function	NN
cord-306904-8iteddug	800	19	by	by	IN
cord-306904-8iteddug	800	20	posttranslational	posttranslational	JJ
cord-306904-8iteddug	800	21	modifications	modification	NNS
cord-306904-8iteddug	800	22	Characterization	characterization	NN
cord-306904-8iteddug	800	23	of	of	IN
cord-306904-8iteddug	800	24	the	the	DT
cord-306904-8iteddug	800	25	murine	murine	JJ
cord-306904-8iteddug	800	26	SIRT3	sirt3	JJ
cord-306904-8iteddug	800	27	mitochondrial	mitochondrial	JJ
cord-306904-8iteddug	800	28	localization	localization	NN
cord-306904-8iteddug	800	29	sequence	sequence	NN
cord-306904-8iteddug	800	30	and	and	CC
cord-306904-8iteddug	800	31	comparison	comparison	NN
cord-306904-8iteddug	800	32	of	of	IN
cord-306904-8iteddug	800	33	mitochondrial	mitochondrial	JJ
cord-306904-8iteddug	800	34	enrichment	enrichment	NN
cord-306904-8iteddug	800	35	and	and	CC
cord-306904-8iteddug	800	36	deacetylase	deacetylase	NN
cord-306904-8iteddug	800	37	activity	activity	NN
cord-306904-8iteddug	800	38	of	of	IN
cord-306904-8iteddug	800	39	long	long	JJ
cord-306904-8iteddug	800	40	and	and	CC
cord-306904-8iteddug	800	41	short	short	JJ
cord-306904-8iteddug	800	42	SIRT3	SIRT3	NNS
cord-306904-8iteddug	800	43	isoforms	isoform	NNS
cord-306904-8iteddug	800	44	Distinct	distinct	JJ
cord-306904-8iteddug	800	45	regulation	regulation	NN
cord-306904-8iteddug	800	46	of	of	IN
cord-306904-8iteddug	800	47	mitochondrial	mitochondrial	JJ
cord-306904-8iteddug	800	48	localization	localization	NN
cord-306904-8iteddug	800	49	and	and	CC
cord-306904-8iteddug	800	50	stability	stability	NN
cord-306904-8iteddug	800	51	of	of	IN
cord-306904-8iteddug	800	52	two	two	CD
cord-306904-8iteddug	800	53	human	human	JJ
cord-306904-8iteddug	800	54	Sirt5	sirt5	NN
cord-306904-8iteddug	800	55	isoforms	isoform	NNS
cord-306904-8iteddug	800	56	Transcription	Transcription	NNP
cord-306904-8iteddug	800	57	levels	level	NNS
cord-306904-8iteddug	800	58	of	of	IN
cord-306904-8iteddug	800	59	sirtuin	sirtuin	NNP
cord-306904-8iteddug	800	60	family	family	NN
cord-306904-8iteddug	800	61	in	in	IN
cord-306904-8iteddug	800	62	neural	neural	JJ
cord-306904-8iteddug	800	63	stem	stem	NN
cord-306904-8iteddug	800	64	cells	cell	NNS
cord-306904-8iteddug	800	65	and	and	CC
cord-306904-8iteddug	800	66	brain	brain	NN
cord-306904-8iteddug	800	67	tissues	tissue	NNS
cord-306904-8iteddug	800	68	of	of	IN
cord-306904-8iteddug	800	69	adult	adult	NN
cord-306904-8iteddug	800	70	mice	mouse	NNS
cord-306904-8iteddug	800	71	Evolutionarily	evolutionarily	RB
cord-306904-8iteddug	800	72	conserved	conserved	JJ
cord-306904-8iteddug	800	73	and	and	CC
cord-306904-8iteddug	800	74	nonconserved	nonconserved	JJ
cord-306904-8iteddug	800	75	cellular	cellular	JJ
cord-306904-8iteddug	800	76	localizations	localization	NNS
cord-306904-8iteddug	800	77	and	and	CC
cord-306904-8iteddug	800	78	functions	function	NNS
cord-306904-8iteddug	800	79	of	of	IN
cord-306904-8iteddug	800	80	human	human	JJ
cord-306904-8iteddug	800	81	SIRT	SIRT	NNP
cord-306904-8iteddug	800	82	proteins	protein	NNS
cord-306904-8iteddug	800	83	Interphase	Interphase	NNP
cord-306904-8iteddug	800	84	nucleo	nucleo	JJ
cord-306904-8iteddug	800	85	-	-	JJ
cord-306904-8iteddug	800	86	cytoplasmic	cytoplasmic	JJ
cord-306904-8iteddug	800	87	shuttling	shuttling	NN
cord-306904-8iteddug	800	88	and	and	CC
cord-306904-8iteddug	800	89	localization	localization	NN
cord-306904-8iteddug	800	90	of	of	IN
cord-306904-8iteddug	800	91	SIRT2	sirt2	NN
cord-306904-8iteddug	800	92	during	during	IN
cord-306904-8iteddug	800	93	mitosis	mitosis	NN
cord-306904-8iteddug	800	94	Alternative	alternative	JJ
cord-306904-8iteddug	800	95	splicing	splicing	NN
cord-306904-8iteddug	800	96	in	in	IN
cord-306904-8iteddug	800	97	concert	concert	NN
cord-306904-8iteddug	800	98	with	with	IN
cord-306904-8iteddug	800	99	protein	protein	NN
cord-306904-8iteddug	800	100	intrinsic	intrinsic	JJ
cord-306904-8iteddug	800	101	disorder	disorder	NN
cord-306904-8iteddug	801	1	enables	enable	NNS
cord-306904-8iteddug	801	2	increased	increase	VBN
cord-306904-8iteddug	801	3	functional	functional	JJ
cord-306904-8iteddug	801	4	diversity	diversity	NN
cord-306904-8iteddug	801	5	in	in	IN
cord-306904-8iteddug	801	6	multicellular	multicellular	JJ
cord-306904-8iteddug	801	7	organisms	organism	NNS
cord-306904-8iteddug	801	8	Tissue	tissue	NN
cord-306904-8iteddug	801	9	-	-	HYPH
cord-306904-8iteddug	801	10	specific	specific	JJ
cord-306904-8iteddug	801	11	splicing	splicing	NN
cord-306904-8iteddug	801	12	of	of	IN
cord-306904-8iteddug	801	13	disordered	disordered	JJ
cord-306904-8iteddug	801	14	segments	segment	NNS
cord-306904-8iteddug	801	15	that	that	WDT
cord-306904-8iteddug	801	16	embed	embed	VBP
cord-306904-8iteddug	801	17	binding	binding	NN
cord-306904-8iteddug	801	18	motifs	motif	NNS
cord-306904-8iteddug	802	1	rewires	rewires	NNP
cord-306904-8iteddug	802	2	protein	protein	NN
cord-306904-8iteddug	802	3	interaction	interaction	NN
cord-306904-8iteddug	802	4	networks	network	NNS
cord-306904-8iteddug	802	5	Alternative	alternative	JJ
cord-306904-8iteddug	802	6	splicing	splicing	NN
cord-306904-8iteddug	802	7	of	of	IN
cord-306904-8iteddug	802	8	intrinsically	intrinsically	RB
cord-306904-8iteddug	802	9	disordered	disordered	JJ
cord-306904-8iteddug	802	10	regions	region	NNS
cord-306904-8iteddug	802	11	and	and	CC
cord-306904-8iteddug	802	12	rewiring	rewiring	NN
cord-306904-8iteddug	802	13	of	of	IN
cord-306904-8iteddug	802	14	protein	protein	NN
cord-306904-8iteddug	802	15	interactions	interaction	NNS
cord-306904-8iteddug	802	16	Effect	Effect	NNP
cord-306904-8iteddug	802	17	of	of	IN
cord-306904-8iteddug	802	18	C	c	NN
cord-306904-8iteddug	802	19	-	-	HYPH
cord-306904-8iteddug	802	20	terminal	terminal	NN
cord-306904-8iteddug	802	21	sequence	sequence	NN
cord-306904-8iteddug	802	22	on	on	IN
cord-306904-8iteddug	802	23	competitive	competitive	JJ
cord-306904-8iteddug	802	24	semaphorin	semaphorin	NN
cord-306904-8iteddug	802	25	binding	bind	VBG
cord-306904-8iteddug	802	26	to	to	IN
cord-306904-8iteddug	802	27	neuropilin-1	neuropilin-1	NNP
cord-306904-8iteddug	802	28	Furin	Furin	NNP
cord-306904-8iteddug	802	29	processing	processing	NN
cord-306904-8iteddug	802	30	of	of	IN
cord-306904-8iteddug	802	31	semaphorin	semaphorin	NNP
cord-306904-8iteddug	802	32	3F	3F	NNP
cord-306904-8iteddug	802	33	determines	determine	VBZ
cord-306904-8iteddug	802	34	its	-PRON-	PRP$
cord-306904-8iteddug	802	35	anti	anti	JJ
cord-306904-8iteddug	802	36	-	-	JJ
cord-306904-8iteddug	802	37	angiogenic	angiogenic	JJ
cord-306904-8iteddug	802	38	activity	activity	NN
cord-306904-8iteddug	802	39	by	by	IN
cord-306904-8iteddug	802	40	regulating	regulate	VBG
cord-306904-8iteddug	802	41	direct	direct	JJ
cord-306904-8iteddug	802	42	binding	binding	NN
cord-306904-8iteddug	802	43	and	and	CC
cord-306904-8iteddug	802	44	competition	competition	NN
cord-306904-8iteddug	802	45	for	for	IN
cord-306904-8iteddug	802	46	neuropilin	neuropilin	NNP
cord-306904-8iteddug	802	47	Structural	structural	JJ
cord-306904-8iteddug	802	48	basis	basis	NN
cord-306904-8iteddug	802	49	for	for	IN
cord-306904-8iteddug	802	50	ligand	ligand	NN
cord-306904-8iteddug	802	51	and	and	CC
cord-306904-8iteddug	802	52	heparin	heparin	NN
cord-306904-8iteddug	802	53	binding	bind	VBG
cord-306904-8iteddug	802	54	to	to	IN
cord-306904-8iteddug	802	55	neuropilin	neuropilin	NNP
cord-306904-8iteddug	802	56	B	B	NNP
cord-306904-8iteddug	802	57	domains	domain	NNS
cord-306904-8iteddug	803	1	Structural	structural	JJ
cord-306904-8iteddug	803	2	basis	basis	NN
cord-306904-8iteddug	803	3	for	for	IN
cord-306904-8iteddug	803	4	selective	selective	JJ
cord-306904-8iteddug	803	5	vascular	vascular	JJ
cord-306904-8iteddug	803	6	endothelial	endothelial	JJ
cord-306904-8iteddug	803	7	growth	growth	NN
cord-306904-8iteddug	803	8	factor	factor	NN
cord-306904-8iteddug	803	9	-	-	:
cord-306904-8iteddug	803	10	A	a	NN
cord-306904-8iteddug	803	11	(	(	-LRB-
cord-306904-8iteddug	803	12	VEGF	VEGF	NNP
cord-306904-8iteddug	803	13	-	-	HYPH
cord-306904-8iteddug	803	14	A	A	NNP
cord-306904-8iteddug	803	15	)	)	-RRB-
cord-306904-8iteddug	803	16	binding	bind	VBG
cord-306904-8iteddug	803	17	to	to	IN
cord-306904-8iteddug	803	18	neuropilin-1	neuropilin-1	NNP
cord-306904-8iteddug	803	19	New	New	NNP
cord-306904-8iteddug	803	20	prospects	prospect	NNS
cord-306904-8iteddug	803	21	in	in	IN
cord-306904-8iteddug	803	22	the	the	DT
cord-306904-8iteddug	803	23	roles	role	NNS
cord-306904-8iteddug	803	24	of	of	IN
cord-306904-8iteddug	803	25	the	the	DT
cord-306904-8iteddug	803	26	C	C	NNP
cord-306904-8iteddug	803	27	-	-	HYPH
cord-306904-8iteddug	803	28	terminal	terminal	NN
cord-306904-8iteddug	803	29	domains	domain	NNS
cord-306904-8iteddug	803	30	of	of	IN
cord-306904-8iteddug	803	31	VEGF	VEGF	NNP
cord-306904-8iteddug	803	32	-	-	HYPH
cord-306904-8iteddug	803	33	A	A	NNP
cord-306904-8iteddug	803	34	and	and	CC
cord-306904-8iteddug	803	35	their	-PRON-	PRP$
cord-306904-8iteddug	803	36	cooperation	cooperation	NN
cord-306904-8iteddug	803	37	for	for	IN
cord-306904-8iteddug	803	38	ligand	ligand	NN
cord-306904-8iteddug	803	39	binding	binding	NN
cord-306904-8iteddug	803	40	,	,	,
cord-306904-8iteddug	803	41	cellular	cellular	JJ
cord-306904-8iteddug	803	42	signaling	signaling	NN
cord-306904-8iteddug	803	43	and	and	CC
cord-306904-8iteddug	803	44	vessels	vessel	NNS
cord-306904-8iteddug	803	45	formation	formation	NN
cord-306904-8iteddug	803	46	X	x	NN
cord-306904-8iteddug	803	47	-	-	NN
cord-306904-8iteddug	803	48	ray	ray	NNP
cord-306904-8iteddug	803	49	crystal	crystal	NN
cord-306904-8iteddug	803	50	structure	structure	NN
cord-306904-8iteddug	803	51	of	of	IN
cord-306904-8iteddug	803	52	bovine	bovine	JJ
cord-306904-8iteddug	803	53	3	3	CD
cord-306904-8iteddug	803	54	Glu	glu	NN
cord-306904-8iteddug	803	55	-	-	HYPH
cord-306904-8iteddug	803	56	osteocalcin	osteocalcin	JJ
cord-306904-8iteddug	803	57	Direct	direct	JJ
cord-306904-8iteddug	803	58	identification	identification	NN
cord-306904-8iteddug	803	59	of	of	IN
cord-306904-8iteddug	803	60	the	the	DT
cord-306904-8iteddug	803	61	calcium	calcium	NN
cord-306904-8iteddug	803	62	-	-	HYPH
cord-306904-8iteddug	803	63	binding	bind	VBG
cord-306904-8iteddug	803	64	amino	amino	NN
cord-306904-8iteddug	803	65	acid	acid	NN
cord-306904-8iteddug	803	66	,	,	,
cord-306904-8iteddug	803	67	gamma	gamma	NN
cord-306904-8iteddug	803	68	-	-	HYPH
cord-306904-8iteddug	803	69	carboxyglutamate	carboxyglutamate	NNP
cord-306904-8iteddug	803	70	,	,	,
cord-306904-8iteddug	803	71	in	in	IN
cord-306904-8iteddug	803	72	mineralized	mineralized	JJ
cord-306904-8iteddug	803	73	tissue	tissue	NN
cord-306904-8iteddug	803	74	Characterization	characterization	NN
cord-306904-8iteddug	803	75	of	of	IN
cord-306904-8iteddug	803	76	a	a	DT
cord-306904-8iteddug	803	77	gamma	gamma	JJ
cord-306904-8iteddug	803	78	-	-	HYPH
cord-306904-8iteddug	803	79	carboxyglutamic	carboxyglutamic	JJ
cord-306904-8iteddug	803	80	acid	acid	NN
cord-306904-8iteddug	803	81	-	-	HYPH
cord-306904-8iteddug	803	82	containing	contain	VBG
cord-306904-8iteddug	803	83	protein	protein	NN
cord-306904-8iteddug	803	84	from	from	IN
cord-306904-8iteddug	803	85	bone	bone	NN
cord-306904-8iteddug	804	1	The	the	DT
cord-306904-8iteddug	804	2	vitamin	vitamin	NN
cord-306904-8iteddug	804	3	K	k	NN
cord-306904-8iteddug	804	4	-	-	HYPH
cord-306904-8iteddug	804	5	dependent	dependent	JJ
cord-306904-8iteddug	804	6	carboxylase	carboxylase	NN
cord-306904-8iteddug	804	7	Calcium	calcium	NN
cord-306904-8iteddug	804	8	-	-	HYPH
cord-306904-8iteddug	804	9	dependent	dependent	JJ
cord-306904-8iteddug	804	10	alphahelical	alphahelical	JJ
cord-306904-8iteddug	804	11	structure	structure	NN
cord-306904-8iteddug	804	12	in	in	IN
cord-306904-8iteddug	804	13	osteocalcin	osteocalcin	NN
cord-306904-8iteddug	804	14	A	a	DT
cord-306904-8iteddug	804	15	method	method	NN
cord-306904-8iteddug	804	16	for	for	IN
cord-306904-8iteddug	804	17	decarboxylation	decarboxylation	NN
cord-306904-8iteddug	804	18	of	of	IN
cord-306904-8iteddug	804	19	gamma	gamma	NN
cord-306904-8iteddug	804	20	-	-	HYPH
cord-306904-8iteddug	804	21	carboxyglutamic	carboxyglutamic	JJ
cord-306904-8iteddug	804	22	acid	acid	NN
cord-306904-8iteddug	804	23	in	in	IN
cord-306904-8iteddug	804	24	proteins	protein	NNS
cord-306904-8iteddug	804	25	.	.	.
cord-306904-8iteddug	805	1	Properties	property	NNS
cord-306904-8iteddug	805	2	of	of	IN
cord-306904-8iteddug	805	3	the	the	DT
cord-306904-8iteddug	805	4	decarboxylated	decarboxylate	VBN
cord-306904-8iteddug	805	5	gamma	gamma	NN
cord-306904-8iteddug	805	6	-	-	HYPH
cord-306904-8iteddug	805	7	carboxyglutamic	carboxyglutamic	JJ
cord-306904-8iteddug	805	8	acid	acid	NN
cord-306904-8iteddug	805	9	protein	protein	NN
cord-306904-8iteddug	805	10	from	from	IN
cord-306904-8iteddug	805	11	calf	calf	NN
cord-306904-8iteddug	805	12	bone	bone	NN
cord-306904-8iteddug	805	13	Coordinated	coordinated	JJ
cord-306904-8iteddug	805	14	transcriptional	transcriptional	JJ
cord-306904-8iteddug	805	15	regulation	regulation	NN
cord-306904-8iteddug	805	16	of	of	IN
cord-306904-8iteddug	805	17	Hspa1a	hspa1a	CD
cord-306904-8iteddug	805	18	gene	gene	NN
cord-306904-8iteddug	805	19	by	by	IN
cord-306904-8iteddug	805	20	multiple	multiple	JJ
cord-306904-8iteddug	805	21	transcription	transcription	NN
cord-306904-8iteddug	805	22	factors	factor	NNS
cord-306904-8iteddug	805	23	:	:	:
cord-306904-8iteddug	805	24	crucial	crucial	JJ
cord-306904-8iteddug	805	25	roles	role	NNS
cord-306904-8iteddug	805	26	for	for	IN
cord-306904-8iteddug	805	27	HSF-1	HSF-1	NNP
cord-306904-8iteddug	805	28	Plasma	Plasma	NNP
cord-306904-8iteddug	805	29	levels	level	NNS
cord-306904-8iteddug	805	30	of	of	IN
cord-306904-8iteddug	805	31	Hsp70	Hsp70	NNP
cord-306904-8iteddug	805	32	and	and	CC
cord-306904-8iteddug	805	33	anti	anti	JJ
cord-306904-8iteddug	805	34	-	-	JJ
cord-306904-8iteddug	805	35	Hsp70	Hsp70	NNP
cord-306904-8iteddug	805	36	antibody	antibody	NN
cord-306904-8iteddug	805	37	predict	predict	VB
cord-306904-8iteddug	805	38	risk	risk	NN
cord-306904-8iteddug	805	39	of	of	IN
cord-306904-8iteddug	805	40	acute	acute	JJ
cord-306904-8iteddug	805	41	coronary	coronary	JJ
cord-306904-8iteddug	805	42	syndrome	syndrome	NN
cord-306904-8iteddug	805	43	Heat	Heat	NNP
cord-306904-8iteddug	805	44	shock	shock	NN
cord-306904-8iteddug	805	45	protein	protein	NN
cord-306904-8iteddug	805	46	70	70	CD
cord-306904-8iteddug	805	47	kDa	kDa	NNS
cord-306904-8iteddug	805	48	:	:	:
cord-306904-8iteddug	805	49	molecular	molecular	JJ
cord-306904-8iteddug	805	50	biology	biology	NN
cord-306904-8iteddug	805	51	,	,	,
cord-306904-8iteddug	805	52	biochemistry	biochemistry	NN
cord-306904-8iteddug	805	53	,	,	,
cord-306904-8iteddug	805	54	and	and	CC
cord-306904-8iteddug	805	55	physiology	physiology	NN
cord-306904-8iteddug	805	56	Heat	heat	NN
cord-306904-8iteddug	805	57	shock	shock	NN
cord-306904-8iteddug	805	58	proteins	protein	NNS
cord-306904-8iteddug	805	59	in	in	IN
cord-306904-8iteddug	805	60	breast	breast	NN
cord-306904-8iteddug	805	61	cancer	cancer	NN
cord-306904-8iteddug	805	62	progression	progression	NN
cord-306904-8iteddug	805	63	-	-	:
cord-306904-8iteddug	805	64	a	a	DT
cord-306904-8iteddug	805	65	suitable	suitable	JJ
cord-306904-8iteddug	805	66	case	case	NN
cord-306904-8iteddug	805	67	for	for	IN
cord-306904-8iteddug	805	68	treatment	treatment	NN
cord-306904-8iteddug	805	69	?	?	.
cord-306904-8iteddug	806	1	Impaired	impaired	JJ
cord-306904-8iteddug	806	2	heat	heat	NN
cord-306904-8iteddug	806	3	shock	shock	NN
cord-306904-8iteddug	806	4	response	response	NN
cord-306904-8iteddug	806	5	in	in	IN
cord-306904-8iteddug	806	6	cells	cell	NNS
cord-306904-8iteddug	806	7	expressing	express	VBG
cord-306904-8iteddug	806	8	full	full	JJ
cord-306904-8iteddug	806	9	-	-	HYPH
cord-306904-8iteddug	806	10	length	length	NN
cord-306904-8iteddug	806	11	polyglutamineexpanded	polyglutamineexpande	VBN
cord-306904-8iteddug	806	12	huntingtin	huntingtin	NNPS
cord-306904-8iteddug	807	1	The	the	DT
cord-306904-8iteddug	807	2	heat	heat	NN
cord-306904-8iteddug	807	3	shock	shock	NN
cord-306904-8iteddug	807	4	factor	factor	NN
cord-306904-8iteddug	807	5	family	family	NN
cord-306904-8iteddug	807	6	and	and	CC
cord-306904-8iteddug	807	7	adaptation	adaptation	NN
cord-306904-8iteddug	808	1	to	to	IN
cord-306904-8iteddug	808	2	proteotoxic	proteotoxic	NNP
cord-306904-8iteddug	808	3	stress	stress	NN
cord-306904-8iteddug	809	1	Phosphorylated	Phosphorylated	NNP
cord-306904-8iteddug	809	2	CREB	CREB	NNP
cord-306904-8iteddug	809	3	binds	bind	VBZ
cord-306904-8iteddug	809	4	specifically	specifically	RB
cord-306904-8iteddug	809	5	to	to	IN
cord-306904-8iteddug	809	6	the	the	DT
cord-306904-8iteddug	809	7	nuclear	nuclear	JJ
cord-306904-8iteddug	809	8	protein	protein	NN
cord-306904-8iteddug	809	9	CBP	CBP	NNP
cord-306904-8iteddug	809	10	Activation	Activation	NNP
cord-306904-8iteddug	809	11	of	of	IN
cord-306904-8iteddug	809	12	cAMP	camp	NN
cord-306904-8iteddug	809	13	and	and	CC
cord-306904-8iteddug	809	14	mitogen	mitogen	NNP
cord-306904-8iteddug	809	15	responsive	responsive	JJ
cord-306904-8iteddug	809	16	genes	gene	NNS
cord-306904-8iteddug	809	17	relies	rely	VBZ
cord-306904-8iteddug	809	18	on	on	IN
cord-306904-8iteddug	809	19	a	a	DT
cord-306904-8iteddug	809	20	common	common	JJ
cord-306904-8iteddug	809	21	nuclear	nuclear	JJ
cord-306904-8iteddug	809	22	factor	factor	NN
cord-306904-8iteddug	809	23	Nuclear	Nuclear	NNP
cord-306904-8iteddug	809	24	protein	protein	NN
cord-306904-8iteddug	809	25	CBP	CBP	NNP
cord-306904-8iteddug	809	26	is	be	VBZ
cord-306904-8iteddug	809	27	a	a	DT
cord-306904-8iteddug	809	28	coactivator	coactivator	NN
cord-306904-8iteddug	809	29	for	for	IN
cord-306904-8iteddug	809	30	the	the	DT
cord-306904-8iteddug	809	31	transcription	transcription	NN
cord-306904-8iteddug	809	32	factor	factor	NN
cord-306904-8iteddug	809	33	CREB	CREB	NNP
cord-306904-8iteddug	809	34	A	a	DT
cord-306904-8iteddug	809	35	multiplicity	multiplicity	NN
cord-306904-8iteddug	809	36	of	of	IN
cord-306904-8iteddug	809	37	CCAAT	CCAAT	NNP
cord-306904-8iteddug	809	38	box	box	NN
cord-306904-8iteddug	809	39	-	-	HYPH
cord-306904-8iteddug	809	40	binding	bind	VBG
cord-306904-8iteddug	809	41	proteins	protein	NNS
cord-306904-8iteddug	810	1	A	a	DT
cord-306904-8iteddug	810	2	survey	survey	NN
cord-306904-8iteddug	810	3	of	of	IN
cord-306904-8iteddug	810	4	178	178	CD
cord-306904-8iteddug	810	5	NF	NF	NNP
cord-306904-8iteddug	810	6	-	-	HYPH
cord-306904-8iteddug	810	7	Y	Y	NNP
cord-306904-8iteddug	810	8	binding	bind	VBG
cord-306904-8iteddug	810	9	CCAAT	CCAAT	NNP
cord-306904-8iteddug	810	10	boxes	box	NNS
cord-306904-8iteddug	811	1	A	a	DT
cord-306904-8iteddug	811	2	CCAAT	CCAAT	NNP
cord-306904-8iteddug	811	3	box	box	NN
cord-306904-8iteddug	811	4	confers	confer	VBZ
cord-306904-8iteddug	811	5	cell	cell	NN
cord-306904-8iteddug	811	6	-	-	HYPH
cord-306904-8iteddug	811	7	type	type	NN
cord-306904-8iteddug	811	8	-	-	HYPH
cord-306904-8iteddug	811	9	specific	specific	JJ
cord-306904-8iteddug	811	10	regulation	regulation	NN
cord-306904-8iteddug	811	11	on	on	IN
cord-306904-8iteddug	811	12	the	the	DT
cord-306904-8iteddug	811	13	Xenopus	Xenopus	NNP
cord-306904-8iteddug	811	14	hsp70	hsp70	POS
cord-306904-8iteddug	811	15	gene	gene	NN
cord-306904-8iteddug	811	16	in	in	IN
cord-306904-8iteddug	811	17	oocytes	oocyte	NNS
cord-306904-8iteddug	812	1	HSP	HSP	NNP
cord-306904-8iteddug	812	2	-	-	HYPH
cord-306904-8iteddug	812	3	CBF	CBF	NNP
cord-306904-8iteddug	812	4	is	be	VBZ
cord-306904-8iteddug	812	5	an	an	DT
cord-306904-8iteddug	812	6	NF	NF	NNP
cord-306904-8iteddug	812	7	-	-	HYPH
cord-306904-8iteddug	812	8	Y	y	NN
cord-306904-8iteddug	812	9	-	-	HYPH
cord-306904-8iteddug	812	10	dependent	dependent	JJ
cord-306904-8iteddug	812	11	coactivator	coactivator	NN
cord-306904-8iteddug	812	12	of	of	IN
cord-306904-8iteddug	812	13	the	the	DT
cord-306904-8iteddug	812	14	heat	heat	NN
cord-306904-8iteddug	812	15	shock	shock	NN
cord-306904-8iteddug	812	16	promoters	promoter	NNS
cord-306904-8iteddug	812	17	CCAAT	CCAAT	NNP
cord-306904-8iteddug	812	18	boxes	box	NNS
cord-306904-8iteddug	812	19	Sequence	sequence	NN
cord-306904-8iteddug	812	20	-	-	HYPH
cord-306904-8iteddug	812	21	specific	specific	JJ
cord-306904-8iteddug	812	22	transcription	transcription	NN
cord-306904-8iteddug	812	23	factor	factor	NN
cord-306904-8iteddug	813	1	NF	NF	NNP
cord-306904-8iteddug	813	2	-	-	HYPH
cord-306904-8iteddug	813	3	Y	Y	NNP
cord-306904-8iteddug	813	4	displays	display	VBZ
cord-306904-8iteddug	813	5	histone	histone	NN
cord-306904-8iteddug	813	6	-	-	HYPH
cord-306904-8iteddug	813	7	like	like	JJ
cord-306904-8iteddug	813	8	DNA	dna	NN
cord-306904-8iteddug	813	9	binding	binding	NN
cord-306904-8iteddug	813	10	and	and	CC
cord-306904-8iteddug	813	11	H2B	h2b	NN
cord-306904-8iteddug	813	12	-	-	HYPH
cord-306904-8iteddug	813	13	like	like	JJ
cord-306904-8iteddug	813	14	ubiquitination	ubiquitination	NN
cord-306904-8iteddug	813	15	Role	role	NN
cord-306904-8iteddug	813	16	of	of	IN
cord-306904-8iteddug	813	17	the	the	DT
cord-306904-8iteddug	813	18	NF	NF	NNP
cord-306904-8iteddug	813	19	-	-	HYPH
cord-306904-8iteddug	813	20	kappaB	kappaB	NNP
cord-306904-8iteddug	813	21	signaling	signal	VBG
cord-306904-8iteddug	813	22	pathway	pathway	NN
cord-306904-8iteddug	813	23	and	and	CC
cord-306904-8iteddug	813	24	kappaB	kappaB	NNP
cord-306904-8iteddug	813	25	cis	cis	NNP
cord-306904-8iteddug	813	26	-	-	HYPH
cord-306904-8iteddug	813	27	regulatory	regulatory	JJ
cord-306904-8iteddug	813	28	elements	element	NNS
cord-306904-8iteddug	813	29	on	on	IN
cord-306904-8iteddug	813	30	the	the	DT
cord-306904-8iteddug	813	31	IRF-1	IRF-1	NNP
cord-306904-8iteddug	813	32	and	and	CC
cord-306904-8iteddug	813	33	iNOS	inos	JJ
cord-306904-8iteddug	813	34	promoter	promoter	NN
cord-306904-8iteddug	813	35	regions	region	NNS
cord-306904-8iteddug	813	36	in	in	IN
cord-306904-8iteddug	813	37	mycobacterial	mycobacterial	NNP
cord-306904-8iteddug	813	38	lipoarabinomannan	lipoarabinomannan	NNP
cord-306904-8iteddug	813	39	induction	induction	NNP
cord-306904-8iteddug	813	40	of	of	IN
cord-306904-8iteddug	813	41	nitric	nitric	NN
cord-306904-8iteddug	813	42	oxide	oxide	NN
cord-306904-8iteddug	813	43	Intrinsic	intrinsic	JJ
cord-306904-8iteddug	813	44	disorder	disorder	NN
cord-306904-8iteddug	813	45	in	in	IN
cord-306904-8iteddug	813	46	transcription	transcription	NN
cord-306904-8iteddug	813	47	factors	factor	NNS
cord-306904-8iteddug	813	48	HSF	HSF	NNP
cord-306904-8iteddug	813	49	transcription	transcription	NN
cord-306904-8iteddug	813	50	factor	factor	NN
cord-306904-8iteddug	813	51	family	family	NN
cord-306904-8iteddug	813	52	,	,	,
cord-306904-8iteddug	813	53	heat	heat	NN
cord-306904-8iteddug	813	54	shock	shock	NN
cord-306904-8iteddug	813	55	response	response	NN
cord-306904-8iteddug	813	56	,	,	,
cord-306904-8iteddug	813	57	and	and	CC
cord-306904-8iteddug	813	58	protein	protein	NN
cord-306904-8iteddug	813	59	intrinsic	intrinsic	JJ
cord-306904-8iteddug	813	60	disorder	disorder	NN
cord-306904-8iteddug	814	1	Intrinsic	intrinsic	JJ
cord-306904-8iteddug	814	2	disorder	disorder	NN
cord-306904-8iteddug	814	3	in	in	IN
cord-306904-8iteddug	814	4	proteins	protein	NNS
cord-306904-8iteddug	814	5	involved	involve	VBN
cord-306904-8iteddug	814	6	in	in	IN
cord-306904-8iteddug	814	7	the	the	DT
cord-306904-8iteddug	814	8	innate	innate	JJ
cord-306904-8iteddug	814	9	antiviral	antiviral	JJ
cord-306904-8iteddug	814	10	immunity	immunity	NN
cord-306904-8iteddug	814	11	:	:	:
cord-306904-8iteddug	814	12	another	another	DT
cord-306904-8iteddug	814	13	flexible	flexible	JJ
cord-306904-8iteddug	814	14	side	side	NN
cord-306904-8iteddug	814	15	of	of	IN
cord-306904-8iteddug	814	16	a	a	DT
cord-306904-8iteddug	814	17	molecular	molecular	JJ
cord-306904-8iteddug	814	18	arms	arm	NNS
cord-306904-8iteddug	814	19	race	race	NN
cord-306904-8iteddug	814	20	Identification	identification	NN
cord-306904-8iteddug	814	21	of	of	IN
cord-306904-8iteddug	814	22	critical	critical	JJ
cord-306904-8iteddug	814	23	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	814	24	sites	site	NNS
cord-306904-8iteddug	814	25	on	on	IN
cord-306904-8iteddug	814	26	the	the	DT
cord-306904-8iteddug	814	27	carboxy	carboxy	JJ
cord-306904-8iteddug	814	28	tail	tail	NN
cord-306904-8iteddug	814	29	of	of	IN
cord-306904-8iteddug	814	30	melanopsin	melanopsin	NNP
cord-306904-8iteddug	815	1	The	the	DT
cord-306904-8iteddug	815	2	importance	importance	NN
cord-306904-8iteddug	815	3	of	of	IN
cord-306904-8iteddug	815	4	intrinsic	intrinsic	JJ
cord-306904-8iteddug	815	5	disorder	disorder	NN
cord-306904-8iteddug	815	6	for	for	IN
cord-306904-8iteddug	815	7	protein	protein	NN
cord-306904-8iteddug	815	8	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	816	1	Intrinsic	intrinsic	JJ
cord-306904-8iteddug	816	2	disorder	disorder	NN
cord-306904-8iteddug	816	3	-	-	HYPH
cord-306904-8iteddug	816	4	based	base	VBN
cord-306904-8iteddug	816	5	protein	protein	NN
cord-306904-8iteddug	816	6	interactions	interaction	NNS
cord-306904-8iteddug	816	7	and	and	CC
cord-306904-8iteddug	816	8	their	-PRON-	PRP$
cord-306904-8iteddug	816	9	modulators	modulator	NNS
cord-306904-8iteddug	817	1	The	the	DT
cord-306904-8iteddug	817	2	structural	structural	JJ
cord-306904-8iteddug	817	3	and	and	CC
cord-306904-8iteddug	817	4	functional	functional	JJ
cord-306904-8iteddug	817	5	signatures	signature	NNS
cord-306904-8iteddug	817	6	of	of	IN
cord-306904-8iteddug	817	7	proteins	protein	NNS
cord-306904-8iteddug	817	8	that	that	WDT
cord-306904-8iteddug	817	9	undergo	undergo	VBP
cord-306904-8iteddug	817	10	multiple	multiple	JJ
cord-306904-8iteddug	817	11	events	event	NNS
cord-306904-8iteddug	817	12	of	of	IN
cord-306904-8iteddug	817	13	post	post	JJ
cord-306904-8iteddug	817	14	-	-	JJ
cord-306904-8iteddug	817	15	translational	translational	JJ
cord-306904-8iteddug	817	16	modification	modification	NN
cord-306904-8iteddug	817	17	Antiviral	Antiviral	NNP
cord-306904-8iteddug	817	18	mechanisms	mechanism	NNS
cord-306904-8iteddug	817	19	of	of	IN
cord-306904-8iteddug	817	20	human	human	JJ
cord-306904-8iteddug	817	21	defensins	defensin	NNS
cord-306904-8iteddug	817	22	Identification	Identification	NNP
cord-306904-8iteddug	817	23	of	of	IN
cord-306904-8iteddug	817	24	intrinsic	intrinsic	JJ
cord-306904-8iteddug	817	25	order	order	NN
cord-306904-8iteddug	817	26	and	and	CC
cord-306904-8iteddug	817	27	disorder	disorder	NN
cord-306904-8iteddug	817	28	in	in	IN
cord-306904-8iteddug	817	29	the	the	DT
cord-306904-8iteddug	817	30	DNA	dna	NN
cord-306904-8iteddug	817	31	repair	repair	NN
cord-306904-8iteddug	817	32	protein	protein	NN
cord-306904-8iteddug	817	33	XPA	XPA	NNP
cord-306904-8iteddug	817	34	Sweeping	sweep	VBG
cord-306904-8iteddug	817	35	away	away	RB
cord-306904-8iteddug	817	36	protein	protein	NN
cord-306904-8iteddug	817	37	aggregation	aggregation	NN
cord-306904-8iteddug	817	38	with	with	IN
cord-306904-8iteddug	817	39	entropic	entropic	JJ
cord-306904-8iteddug	817	40	bristles	bristle	NNS
cord-306904-8iteddug	817	41	:	:	:
cord-306904-8iteddug	817	42	intrinsically	intrinsically	RB
cord-306904-8iteddug	817	43	disordered	disordered	JJ
cord-306904-8iteddug	817	44	protein	protein	NN
cord-306904-8iteddug	817	45	fusions	fusion	NNS
cord-306904-8iteddug	817	46	enhance	enhance	VBP
cord-306904-8iteddug	817	47	soluble	soluble	JJ
cord-306904-8iteddug	817	48	expression	expression	NN
cord-306904-8iteddug	818	1	Multiple	multiple	JJ
cord-306904-8iteddug	818	2	mechanisms	mechanism	NNS
cord-306904-8iteddug	818	3	for	for	IN
cord-306904-8iteddug	818	4	E2F	e2f	NN
cord-306904-8iteddug	818	5	binding	bind	VBG
cord-306904-8iteddug	818	6	inhibition	inhibition	NN
cord-306904-8iteddug	818	7	by	by	IN
cord-306904-8iteddug	818	8	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	818	9	of	of	IN
cord-306904-8iteddug	818	10	the	the	DT
cord-306904-8iteddug	818	11	retinoblastoma	retinoblastoma	NN
cord-306904-8iteddug	818	12	protein	protein	NN
cord-306904-8iteddug	818	13	C	c	NN
cord-306904-8iteddug	818	14	-	-	HYPH
cord-306904-8iteddug	818	15	terminal	terminal	NN
cord-306904-8iteddug	818	16	domain	domain	NN
cord-306904-8iteddug	818	17	Cellular	Cellular	NNP
cord-306904-8iteddug	818	18	mechanisms	mechanism	NNS
cord-306904-8iteddug	818	19	of	of	IN
cord-306904-8iteddug	818	20	tumour	tumour	NN
cord-306904-8iteddug	818	21	suppression	suppression	NN
cord-306904-8iteddug	818	22	by	by	IN
cord-306904-8iteddug	818	23	the	the	DT
cord-306904-8iteddug	818	24	retinoblastoma	retinoblastoma	NN
cord-306904-8iteddug	818	25	gene	gene	NN
cord-306904-8iteddug	818	26	Molecular	Molecular	NNP
cord-306904-8iteddug	818	27	mechanisms	mechanism	NNS
cord-306904-8iteddug	818	28	underlying	underlie	VBG
cord-306904-8iteddug	818	29	RB	RB	NNP
cord-306904-8iteddug	818	30	protein	protein	NN
cord-306904-8iteddug	818	31	function	function	NN
cord-306904-8iteddug	818	32	Cell	cell	NN
cord-306904-8iteddug	818	33	cycle	cycle	NN
cord-306904-8iteddug	818	34	-	-	HYPH
cord-306904-8iteddug	818	35	dependent	dependent	JJ
cord-306904-8iteddug	818	36	regulation	regulation	NN
cord-306904-8iteddug	818	37	of	of	IN
cord-306904-8iteddug	818	38	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	818	39	of	of	IN
cord-306904-8iteddug	818	40	the	the	DT
cord-306904-8iteddug	818	41	human	human	JJ
cord-306904-8iteddug	818	42	retinoblastoma	retinoblastoma	NN
cord-306904-8iteddug	818	43	gene	gene	NN
cord-306904-8iteddug	818	44	product	product	NN
cord-306904-8iteddug	819	1	The	the	DT
cord-306904-8iteddug	819	2	retinoblastoma	retinoblastoma	NN
cord-306904-8iteddug	819	3	protein	protein	NN
cord-306904-8iteddug	819	4	copurifies	copurifie	VBZ
cord-306904-8iteddug	819	5	with	with	IN
cord-306904-8iteddug	819	6	E2F	e2f	NN
cord-306904-8iteddug	819	7	-	-	:
cord-306904-8iteddug	819	8	I	-PRON-	PRP
cord-306904-8iteddug	819	9	,	,	,
cord-306904-8iteddug	819	10	an	an	DT
cord-306904-8iteddug	819	11	E1A	e1a	JJ
cord-306904-8iteddug	819	12	-	-	HYPH
cord-306904-8iteddug	819	13	regulated	regulate	VBN
cord-306904-8iteddug	819	14	inhibitor	inhibitor	NN
cord-306904-8iteddug	819	15	of	of	IN
cord-306904-8iteddug	819	16	the	the	DT
cord-306904-8iteddug	819	17	transcription	transcription	NN
cord-306904-8iteddug	819	18	factor	factor	NN
cord-306904-8iteddug	819	19	E2F	E2F	NNP
cord-306904-8iteddug	819	20	Identification	Identification	NNP
cord-306904-8iteddug	819	21	,	,	,
cord-306904-8iteddug	819	22	analysis	analysis	NN
cord-306904-8iteddug	819	23	,	,	,
cord-306904-8iteddug	819	24	and	and	CC
cord-306904-8iteddug	819	25	prediction	prediction	NN
cord-306904-8iteddug	819	26	of	of	IN
cord-306904-8iteddug	819	27	protein	protein	NN
cord-306904-8iteddug	819	28	ubiquitination	ubiquitination	NN
cord-306904-8iteddug	819	29	sites	site	VBZ
cord-306904-8iteddug	819	30	Functional	functional	JJ
cord-306904-8iteddug	819	31	anthology	anthology	NN
cord-306904-8iteddug	819	32	of	of	IN
cord-306904-8iteddug	819	33	intrinsic	intrinsic	JJ
cord-306904-8iteddug	819	34	disorder	disorder	NN
cord-306904-8iteddug	819	35	.	.	.
cord-306904-8iteddug	820	1	1	1	LS
cord-306904-8iteddug	820	2	.	.	.
cord-306904-8iteddug	821	1	Biological	biological	JJ
cord-306904-8iteddug	821	2	processes	process	NNS
cord-306904-8iteddug	821	3	and	and	CC
cord-306904-8iteddug	821	4	functions	function	NNS
cord-306904-8iteddug	821	5	of	of	IN
cord-306904-8iteddug	821	6	proteins	protein	NNS
cord-306904-8iteddug	821	7	with	with	IN
cord-306904-8iteddug	821	8	long	long	JJ
cord-306904-8iteddug	821	9	disordered	disordered	JJ
cord-306904-8iteddug	821	10	regions	region	NNS
cord-306904-8iteddug	821	11	Functional	functional	JJ
cord-306904-8iteddug	821	12	anthology	anthology	NN
cord-306904-8iteddug	821	13	of	of	IN
cord-306904-8iteddug	821	14	intrinsic	intrinsic	JJ
cord-306904-8iteddug	821	15	disorder	disorder	NN
cord-306904-8iteddug	821	16	.	.	.
cord-306904-8iteddug	822	1	2	2	LS
cord-306904-8iteddug	822	2	.	.	.
cord-306904-8iteddug	823	1	Cellular	cellular	JJ
cord-306904-8iteddug	823	2	components	component	NNS
cord-306904-8iteddug	823	3	,	,	,
cord-306904-8iteddug	823	4	domains	domain	NNS
cord-306904-8iteddug	823	5	,	,	,
cord-306904-8iteddug	823	6	technical	technical	JJ
cord-306904-8iteddug	823	7	terms	term	NNS
cord-306904-8iteddug	823	8	,	,	,
cord-306904-8iteddug	823	9	developmental	developmental	JJ
cord-306904-8iteddug	823	10	processes	process	NNS
cord-306904-8iteddug	823	11	,	,	,
cord-306904-8iteddug	823	12	and	and	CC
cord-306904-8iteddug	823	13	coding	code	VBG
cord-306904-8iteddug	823	14	sequence	sequence	NN
cord-306904-8iteddug	823	15	diversities	diversity	NNS
cord-306904-8iteddug	823	16	correlated	correlate	VBN
cord-306904-8iteddug	823	17	with	with	IN
cord-306904-8iteddug	823	18	long	long	JJ
cord-306904-8iteddug	823	19	disordered	disordered	JJ
cord-306904-8iteddug	823	20	regions	region	NNS
cord-306904-8iteddug	823	21	Functional	functional	JJ
cord-306904-8iteddug	823	22	anthology	anthology	NN
cord-306904-8iteddug	823	23	of	of	IN
cord-306904-8iteddug	823	24	intrinsic	intrinsic	JJ
cord-306904-8iteddug	823	25	disorder	disorder	NN
cord-306904-8iteddug	823	26	.	.	.
cord-306904-8iteddug	824	1	3	3	LS
cord-306904-8iteddug	824	2	.	.	.
cord-306904-8iteddug	825	1	Ligands	Ligands	NNP
cord-306904-8iteddug	825	2	,	,	,
cord-306904-8iteddug	825	3	post	post	JJ
cord-306904-8iteddug	825	4	-	-	JJ
cord-306904-8iteddug	825	5	translational	translational	JJ
cord-306904-8iteddug	825	6	modifications	modification	NNS
cord-306904-8iteddug	825	7	,	,	,
cord-306904-8iteddug	825	8	and	and	CC
cord-306904-8iteddug	825	9	diseases	disease	NNS
cord-306904-8iteddug	825	10	associated	associate	VBN
cord-306904-8iteddug	825	11	with	with	IN
cord-306904-8iteddug	825	12	intrinsically	intrinsically	RB
cord-306904-8iteddug	825	13	disordered	disordered	JJ
cord-306904-8iteddug	825	14	proteins	protein	NNS
cord-306904-8iteddug	825	15	Structural	structural	JJ
cord-306904-8iteddug	825	16	and	and	CC
cord-306904-8iteddug	825	17	biochemical	biochemical	JJ
cord-306904-8iteddug	825	18	characterization	characterization	NN
cord-306904-8iteddug	825	19	of	of	IN
cord-306904-8iteddug	825	20	the	the	DT
cord-306904-8iteddug	825	21	interaction	interaction	NN
cord-306904-8iteddug	825	22	between	between	IN
cord-306904-8iteddug	825	23	LGN	LGN	NNP
cord-306904-8iteddug	825	24	and	and	CC
cord-306904-8iteddug	825	25	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	825	26	Analysis	Analysis	NNP
cord-306904-8iteddug	825	27	of	of	IN
cord-306904-8iteddug	825	28	partner	partner	NN
cord-306904-8iteddug	825	29	of	of	IN
cord-306904-8iteddug	825	30	inscuteable	inscuteable	NNP
cord-306904-8iteddug	825	31	,	,	,
cord-306904-8iteddug	825	32	a	a	DT
cord-306904-8iteddug	825	33	novel	novel	JJ
cord-306904-8iteddug	825	34	player	player	NN
cord-306904-8iteddug	825	35	of	of	IN
cord-306904-8iteddug	825	36	Drosophila	Drosophila	NNP
cord-306904-8iteddug	825	37	asymmetric	asymmetric	JJ
cord-306904-8iteddug	825	38	divisions	division	NNS
cord-306904-8iteddug	825	39	,	,	,
cord-306904-8iteddug	825	40	reveals	reveal	VBZ
cord-306904-8iteddug	825	41	two	two	CD
cord-306904-8iteddug	825	42	distinct	distinct	JJ
cord-306904-8iteddug	825	43	steps	step	NNS
cord-306904-8iteddug	825	44	in	in	IN
cord-306904-8iteddug	825	45	inscuteable	inscuteable	JJ
cord-306904-8iteddug	825	46	apical	apical	JJ
cord-306904-8iteddug	825	47	localization	localization	NN
cord-306904-8iteddug	825	48	Spindle	spindle	NN
cord-306904-8iteddug	825	49	orientation	orientation	NN
cord-306904-8iteddug	825	50	during	during	IN
cord-306904-8iteddug	825	51	asymmetric	asymmetric	JJ
cord-306904-8iteddug	825	52	cell	cell	NN
cord-306904-8iteddug	825	53	division	division	NN
cord-306904-8iteddug	825	54	Mechanisms	Mechanisms	NNPS
cord-306904-8iteddug	825	55	of	of	IN
cord-306904-8iteddug	825	56	asymmetric	asymmetric	JJ
cord-306904-8iteddug	825	57	stem	stem	NN
cord-306904-8iteddug	825	58	cell	cell	NN
cord-306904-8iteddug	825	59	division	division	NN
cord-306904-8iteddug	825	60	LGN	LGN	NNP
cord-306904-8iteddug	825	61	/	/	SYM
cord-306904-8iteddug	825	62	mInsc	mInsc	NNP
cord-306904-8iteddug	825	63	and	and	CC
cord-306904-8iteddug	825	64	LGN	LGN	NNP
cord-306904-8iteddug	825	65	/	/	SYM
cord-306904-8iteddug	825	66	NuMA	NuMA	NNP
cord-306904-8iteddug	825	67	complex	complex	JJ
cord-306904-8iteddug	825	68	structures	structure	NNS
cord-306904-8iteddug	825	69	suggest	suggest	VBP
cord-306904-8iteddug	825	70	distinct	distinct	JJ
cord-306904-8iteddug	825	71	functions	function	NNS
cord-306904-8iteddug	825	72	in	in	IN
cord-306904-8iteddug	825	73	asymmetric	asymmetric	JJ
cord-306904-8iteddug	825	74	cell	cell	NN
cord-306904-8iteddug	825	75	division	division	NN
cord-306904-8iteddug	825	76	for	for	IN
cord-306904-8iteddug	825	77	the	the	DT
cord-306904-8iteddug	825	78	Par3	Par3	NNP
cord-306904-8iteddug	826	1	/mInsc/	/mInsc/	.
cord-306904-8iteddug	827	1	LGN	LGN	NNP
cord-306904-8iteddug	827	2	and	and	CC
cord-306904-8iteddug	827	3	Galphai	Galphai	NNP
cord-306904-8iteddug	827	4	/	/	SYM
cord-306904-8iteddug	827	5	LGN	LGN	NNP
cord-306904-8iteddug	827	6	/	/	SYM
cord-306904-8iteddug	827	7	NuMA	NuMA	NNP
cord-306904-8iteddug	827	8	pathways	pathway	NNS
cord-306904-8iteddug	827	9	Inscuteable	Inscuteable	NNP
cord-306904-8iteddug	827	10	and	and	CC
cord-306904-8iteddug	827	11	NuMA	NuMA	NNP
cord-306904-8iteddug	827	12	proteins	protein	NNS
cord-306904-8iteddug	827	13	bind	bind	VBP
cord-306904-8iteddug	827	14	competitively	competitively	RB
cord-306904-8iteddug	827	15	to	to	IN
cord-306904-8iteddug	827	16	Leu	Leu	NNP
cord-306904-8iteddug	827	17	-	-	HYPH
cord-306904-8iteddug	827	18	Gly	Gly	NNP
cord-306904-8iteddug	827	19	-	-	HYPH
cord-306904-8iteddug	827	20	Asn	Asn	NNP
cord-306904-8iteddug	827	21	repeat	repeat	NN
cord-306904-8iteddug	827	22	-	-	HYPH
cord-306904-8iteddug	827	23	enriched	enrich	VBN
cord-306904-8iteddug	827	24	protein	protein	NN
cord-306904-8iteddug	827	25	(	(	-LRB-
cord-306904-8iteddug	827	26	LGN	LGN	NNP
cord-306904-8iteddug	827	27	)	)	-RRB-
cord-306904-8iteddug	827	28	during	during	IN
cord-306904-8iteddug	827	29	asymmetric	asymmetric	JJ
cord-306904-8iteddug	827	30	cell	cell	NN
cord-306904-8iteddug	827	31	divisions	division	NNS
cord-306904-8iteddug	828	1	Structural	structural	JJ
cord-306904-8iteddug	828	2	basis	basis	NN
cord-306904-8iteddug	828	3	for	for	IN
cord-306904-8iteddug	828	4	interaction	interaction	NN
cord-306904-8iteddug	828	5	between	between	IN
cord-306904-8iteddug	828	6	the	the	DT
cord-306904-8iteddug	828	7	conserved	conserved	JJ
cord-306904-8iteddug	828	8	cell	cell	NN
cord-306904-8iteddug	828	9	polarity	polarity	NN
cord-306904-8iteddug	828	10	proteins	protein	VBZ
cord-306904-8iteddug	828	11	Inscuteable	Inscuteable	NNP
cord-306904-8iteddug	828	12	and	and	CC
cord-306904-8iteddug	828	13	Leu	Leu	NNP
cord-306904-8iteddug	828	14	-	-	HYPH
cord-306904-8iteddug	828	15	Gly	Gly	NNP
cord-306904-8iteddug	828	16	-	-	HYPH
cord-306904-8iteddug	828	17	Asn	Asn	NNP
cord-306904-8iteddug	828	18	repeat	repeat	NN
cord-306904-8iteddug	828	19	-	-	HYPH
cord-306904-8iteddug	828	20	enriched	enrich	VBN
cord-306904-8iteddug	828	21	protein	protein	NN
cord-306904-8iteddug	828	22	(	(	-LRB-
cord-306904-8iteddug	828	23	LGN	LGN	NNP
cord-306904-8iteddug	828	24	)	)	-RRB-
cord-306904-8iteddug	829	1	The	the	DT
cord-306904-8iteddug	829	2	tetratricopeptide	tetratricopeptide	JJ
cord-306904-8iteddug	829	3	repeat	repeat	NN
cord-306904-8iteddug	829	4	:	:	:
cord-306904-8iteddug	830	1	a	a	DT
cord-306904-8iteddug	830	2	structural	structural	JJ
cord-306904-8iteddug	830	3	motif	motif	NN
cord-306904-8iteddug	830	4	mediating	mediate	VBG
cord-306904-8iteddug	830	5	protein	protein	NN
cord-306904-8iteddug	830	6	-	-	HYPH
cord-306904-8iteddug	830	7	protein	protein	NN
cord-306904-8iteddug	830	8	interactions	interaction	NNS
cord-306904-8iteddug	830	9	Return	Return	NNP
cord-306904-8iteddug	830	10	of	of	IN
cord-306904-8iteddug	830	11	the	the	DT
cord-306904-8iteddug	830	12	GDI	GDI	NNP
cord-306904-8iteddug	830	13	:	:	:
cord-306904-8iteddug	830	14	the	the	DT
cord-306904-8iteddug	830	15	GoLoco	GoLoco	NNP
cord-306904-8iteddug	830	16	motif	motif	NN
cord-306904-8iteddug	830	17	in	in	IN
cord-306904-8iteddug	830	18	cell	cell	NN
cord-306904-8iteddug	830	19	division	division	NN
cord-306904-8iteddug	830	20	Mammalian	Mammalian	NNP
cord-306904-8iteddug	830	21	Pins	Pins	NNP
cord-306904-8iteddug	830	22	is	be	VBZ
cord-306904-8iteddug	830	23	a	a	DT
cord-306904-8iteddug	830	24	conformational	conformational	JJ
cord-306904-8iteddug	830	25	switch	switch	NN
cord-306904-8iteddug	830	26	that	that	WDT
cord-306904-8iteddug	830	27	links	link	VBZ
cord-306904-8iteddug	830	28	NuMA	NuMA	NNP
cord-306904-8iteddug	830	29	to	to	TO
cord-306904-8iteddug	830	30	heterotrimeric	heterotrimeric	VB
cord-306904-8iteddug	830	31	G	g	NN
cord-306904-8iteddug	830	32	proteins	protein	NNS
cord-306904-8iteddug	831	1	Distinct	distinct	JJ
cord-306904-8iteddug	831	2	roles	role	NNS
cord-306904-8iteddug	831	3	of	of	IN
cord-306904-8iteddug	831	4	Galphai	Galphai	NNP
cord-306904-8iteddug	831	5	and	and	CC
cord-306904-8iteddug	831	6	Gbeta13F	Gbeta13F	NNP
cord-306904-8iteddug	831	7	subunits	subunit	NNS
cord-306904-8iteddug	831	8	of	of	IN
cord-306904-8iteddug	831	9	the	the	DT
cord-306904-8iteddug	831	10	heterotrimeric	heterotrimeric	NNP
cord-306904-8iteddug	831	11	G	G	NNP
cord-306904-8iteddug	831	12	protein	protein	NN
cord-306904-8iteddug	831	13	complex	complex	NN
cord-306904-8iteddug	831	14	in	in	IN
cord-306904-8iteddug	831	15	the	the	DT
cord-306904-8iteddug	831	16	mediation	mediation	NN
cord-306904-8iteddug	831	17	of	of	IN
cord-306904-8iteddug	831	18	Drosophila	Drosophila	NNP
cord-306904-8iteddug	831	19	neuroblast	neuroblast	JJ
cord-306904-8iteddug	831	20	asymmetric	asymmetric	JJ
cord-306904-8iteddug	831	21	divisions	division	NNS
cord-306904-8iteddug	831	22	TPR	TPR	NNP
cord-306904-8iteddug	831	23	proteins	protein	NNS
cord-306904-8iteddug	831	24	:	:	:
cord-306904-8iteddug	831	25	the	the	DT
cord-306904-8iteddug	831	26	versatile	versatile	JJ
cord-306904-8iteddug	831	27	helix	helix	NN
cord-306904-8iteddug	832	1	The	the	DT
cord-306904-8iteddug	832	2	PDZ	PDZ	NNP
cord-306904-8iteddug	832	3	and	and	CC
cord-306904-8iteddug	832	4	band	band	NN
cord-306904-8iteddug	832	5	4.1	4.1	CD
cord-306904-8iteddug	832	6	containing	contain	VBG
cord-306904-8iteddug	832	7	protein	protein	NN
cord-306904-8iteddug	832	8	Frmpd1	Frmpd1	NNP
cord-306904-8iteddug	832	9	regulates	regulate	VBZ
cord-306904-8iteddug	832	10	the	the	DT
cord-306904-8iteddug	832	11	subcellular	subcellular	JJ
cord-306904-8iteddug	832	12	location	location	NN
cord-306904-8iteddug	832	13	of	of	IN
cord-306904-8iteddug	832	14	activator	activator	NN
cord-306904-8iteddug	832	15	of	of	IN
cord-306904-8iteddug	832	16	G	g	NN
cord-306904-8iteddug	832	17	-	-	HYPH
cord-306904-8iteddug	832	18	protein	protein	NN
cord-306904-8iteddug	832	19	signaling	signal	VBG
cord-306904-8iteddug	832	20	3	3	CD
cord-306904-8iteddug	832	21	and	and	CC
cord-306904-8iteddug	832	22	its	-PRON-	PRP$
cord-306904-8iteddug	832	23	interaction	interaction	NN
cord-306904-8iteddug	832	24	with	with	IN
cord-306904-8iteddug	832	25	G	g	NN
cord-306904-8iteddug	832	26	-	-	HYPH
cord-306904-8iteddug	832	27	proteins	protein	NNS
cord-306904-8iteddug	833	1	The	the	DT
cord-306904-8iteddug	833	2	pairwise	pairwise	JJ
cord-306904-8iteddug	833	3	energy	energy	NN
cord-306904-8iteddug	833	4	content	content	NN
cord-306904-8iteddug	833	5	estimated	estimate	VBN
cord-306904-8iteddug	833	6	from	from	IN
cord-306904-8iteddug	833	7	amino	amino	NN
cord-306904-8iteddug	833	8	acid	acid	NN
cord-306904-8iteddug	833	9	composition	composition	NN
cord-306904-8iteddug	833	10	discriminates	discriminate	VBZ
cord-306904-8iteddug	833	11	between	between	IN
cord-306904-8iteddug	833	12	folded	folded	JJ
cord-306904-8iteddug	833	13	and	and	CC
cord-306904-8iteddug	833	14	intrinsically	intrinsically	RB
cord-306904-8iteddug	833	15	unstructured	unstructured	JJ
cord-306904-8iteddug	833	16	proteins	protein	NNS
cord-306904-8iteddug	834	1	IUPred	iupre	VBN
cord-306904-8iteddug	834	2	:	:	:
cord-306904-8iteddug	835	1	web	web	NN
cord-306904-8iteddug	835	2	server	server	NN
cord-306904-8iteddug	835	3	for	for	IN
cord-306904-8iteddug	835	4	the	the	DT
cord-306904-8iteddug	835	5	prediction	prediction	NN
cord-306904-8iteddug	835	6	of	of	IN
cord-306904-8iteddug	835	7	intrinsically	intrinsically	RB
cord-306904-8iteddug	835	8	unstructured	unstructured	JJ
cord-306904-8iteddug	835	9	regions	region	NNS
cord-306904-8iteddug	835	10	of	of	IN
cord-306904-8iteddug	835	11	proteins	protein	NNS
cord-306904-8iteddug	835	12	based	base	VBN
cord-306904-8iteddug	835	13	on	on	IN
cord-306904-8iteddug	835	14	estimated	estimate	VBN
cord-306904-8iteddug	835	15	energy	energy	NN
cord-306904-8iteddug	835	16	content	content	NN
cord-306904-8iteddug	835	17	Structural	Structural	NNP
cord-306904-8iteddug	835	18	and	and	CC
cord-306904-8iteddug	835	19	Functional	Functional	NNP
cord-306904-8iteddug	835	20	Analysis	Analysis	NNP
cord-306904-8iteddug	835	21	of	of	IN
cord-306904-8iteddug	835	22	Human	Human	NNP
cord-306904-8iteddug	835	23	SIRT1	sirt1	NN
cord-306904-8iteddug	835	24	Aging	aging	NN
cord-306904-8iteddug	835	25	and	and	CC
cord-306904-8iteddug	835	26	disease	disease	NN
cord-306904-8iteddug	835	27	:	:	:
cord-306904-8iteddug	835	28	connections	connection	NNS
cord-306904-8iteddug	835	29	to	to	IN
cord-306904-8iteddug	835	30	sirtuins	sirtuins	NNP
cord-306904-8iteddug	835	31	Sirtuins	Sirtuins	NNP
cord-306904-8iteddug	835	32	in	in	IN
cord-306904-8iteddug	835	33	aging	age	VBG
cord-306904-8iteddug	835	34	and	and	CC
cord-306904-8iteddug	835	35	disease	disease	NN
cord-306904-8iteddug	835	36	Sirtuins	Sirtuins	NNP
cord-306904-8iteddug	835	37	in	in	IN
cord-306904-8iteddug	835	38	aging	age	VBG
cord-306904-8iteddug	835	39	and	and	CC
cord-306904-8iteddug	835	40	agerelated	agerelated	JJ
cord-306904-8iteddug	835	41	disease	disease	NN
cord-306904-8iteddug	835	42	Peptide	Peptide	NNP
cord-306904-8iteddug	835	43	switch	switch	NN
cord-306904-8iteddug	835	44	is	be	VBZ
cord-306904-8iteddug	835	45	essential	essential	JJ
cord-306904-8iteddug	835	46	for	for	IN
cord-306904-8iteddug	835	47	Sirt1	Sirt1	NNS
cord-306904-8iteddug	836	1	deacetylase	deacetylase	NNP
cord-306904-8iteddug	837	1	activity	activity	NN
cord-306904-8iteddug	837	2	SIRT1	SIRT1	NNP
cord-306904-8iteddug	837	3	contains	contain	VBZ
cord-306904-8iteddug	837	4	N	n	CD
cord-306904-8iteddug	837	5	-	-	:
cord-306904-8iteddug	837	6	and	and	CC
cord-306904-8iteddug	837	7	C	c	NN
cord-306904-8iteddug	837	8	-	-	HYPH
cord-306904-8iteddug	837	9	terminal	terminal	NN
cord-306904-8iteddug	837	10	regions	region	NNS
cord-306904-8iteddug	837	11	that	that	WDT
cord-306904-8iteddug	837	12	potentiate	potentiate	VBP
cord-306904-8iteddug	837	13	deacetylase	deacetylase	NN
cord-306904-8iteddug	837	14	activity	activity	NN
cord-306904-8iteddug	837	15	Genealogy	genealogy	NN
cord-306904-8iteddug	837	16	of	of	IN
cord-306904-8iteddug	837	17	an	an	DT
cord-306904-8iteddug	837	18	ancient	ancient	JJ
cord-306904-8iteddug	837	19	protein	protein	NN
cord-306904-8iteddug	837	20	family	family	NN
cord-306904-8iteddug	837	21	:	:	:
cord-306904-8iteddug	837	22	the	the	DT
cord-306904-8iteddug	837	23	Sirtuins	Sirtuins	NNP
cord-306904-8iteddug	837	24	,	,	,
cord-306904-8iteddug	837	25	a	a	DT
cord-306904-8iteddug	837	26	family	family	NN
cord-306904-8iteddug	837	27	of	of	IN
cord-306904-8iteddug	837	28	disordered	disordered	JJ
cord-306904-8iteddug	837	29	members	member	NNS
cord-306904-8iteddug	837	30	Mechanism	Mechanism	NNP
cord-306904-8iteddug	837	31	of	of	IN
cord-306904-8iteddug	837	32	recruitment	recruitment	NN
cord-306904-8iteddug	837	33	and	and	CC
cord-306904-8iteddug	837	34	activation	activation	NN
cord-306904-8iteddug	837	35	of	of	IN
cord-306904-8iteddug	837	36	the	the	DT
cord-306904-8iteddug	837	37	endosome	endosome	NN
cord-306904-8iteddug	837	38	-	-	HYPH
cord-306904-8iteddug	837	39	associated	associate	VBN
cord-306904-8iteddug	837	40	deubiquitinase	deubiquitinase	NN
cord-306904-8iteddug	837	41	AMSH	AMSH	NNP
cord-306904-8iteddug	837	42	Mutations	Mutations	NNPS
cord-306904-8iteddug	837	43	in	in	IN
cord-306904-8iteddug	837	44	STAMBP	STAMBP	NNP
cord-306904-8iteddug	837	45	,	,	,
cord-306904-8iteddug	837	46	encoding	encode	VBG
cord-306904-8iteddug	837	47	a	a	DT
cord-306904-8iteddug	837	48	deubiquitinating	deubiquitinating	NN
cord-306904-8iteddug	837	49	enzyme	enzyme	NN
cord-306904-8iteddug	837	50	,	,	,
cord-306904-8iteddug	837	51	cause	cause	IN
cord-306904-8iteddug	837	52	microcephaly	microcephaly	NNS
cord-306904-8iteddug	837	53	-	-	HYPH
cord-306904-8iteddug	837	54	capillary	capillary	JJ
cord-306904-8iteddug	837	55	malformation	malformation	NN
cord-306904-8iteddug	837	56	syndrome	syndrome	NN
cord-306904-8iteddug	837	57	MPNC	MPNC	NNP
cord-306904-8iteddug	837	58	,	,	,
cord-306904-8iteddug	837	59	a	a	DT
cord-306904-8iteddug	837	60	putative	putative	JJ
cord-306904-8iteddug	837	61	catalytic	catalytic	JJ
cord-306904-8iteddug	837	62	motif	motif	NN
cord-306904-8iteddug	837	63	found	find	VBN
cord-306904-8iteddug	837	64	in	in	IN
cord-306904-8iteddug	837	65	a	a	DT
cord-306904-8iteddug	837	66	subset	subset	NN
cord-306904-8iteddug	837	67	of	of	IN
cord-306904-8iteddug	837	68	MPN	MPN	NNP
cord-306904-8iteddug	837	69	domain	domain	NN
cord-306904-8iteddug	837	70	proteins	protein	NNS
cord-306904-8iteddug	837	71	from	from	IN
cord-306904-8iteddug	837	72	eukaryotes	eukaryote	NNS
cord-306904-8iteddug	837	73	and	and	CC
cord-306904-8iteddug	837	74	prokaryotes	prokaryote	NNS
cord-306904-8iteddug	837	75	,	,	,
cord-306904-8iteddug	837	76	is	be	VBZ
cord-306904-8iteddug	837	77	critical	critical	JJ
cord-306904-8iteddug	837	78	for	for	IN
cord-306904-8iteddug	837	79	Rpn11	Rpn11	NNP
cord-306904-8iteddug	837	80	function	function	NN
cord-306904-8iteddug	837	81	Activation	activation	NN
cord-306904-8iteddug	837	82	of	of	IN
cord-306904-8iteddug	837	83	the	the	DT
cord-306904-8iteddug	837	84	endosome	endosome	NN
cord-306904-8iteddug	837	85	-	-	HYPH
cord-306904-8iteddug	837	86	associated	associate	VBN
cord-306904-8iteddug	837	87	ubiquitin	ubiquitin	NN
cord-306904-8iteddug	837	88	isopeptidase	isopeptidase	IN
cord-306904-8iteddug	837	89	AMSH	AMSH	NNP
cord-306904-8iteddug	837	90	by	by	IN
cord-306904-8iteddug	837	91	STAM	STAM	NNP
cord-306904-8iteddug	837	92	,	,	,
cord-306904-8iteddug	837	93	a	a	DT
cord-306904-8iteddug	837	94	component	component	NN
cord-306904-8iteddug	837	95	of	of	IN
cord-306904-8iteddug	837	96	the	the	DT
cord-306904-8iteddug	837	97	multivesicular	multivesicular	NNP
cord-306904-8iteddug	837	98	body	body	NN
cord-306904-8iteddug	837	99	-	-	HYPH
cord-306904-8iteddug	837	100	sorting	sort	VBG
cord-306904-8iteddug	837	101	machinery	machinery	NN
cord-306904-8iteddug	838	1	The	the	DT
cord-306904-8iteddug	838	2	eukaryotic	eukaryotic	JJ
cord-306904-8iteddug	838	3	linear	linear	JJ
cord-306904-8iteddug	838	4	motif	motif	NN
cord-306904-8iteddug	838	5	resource	resource	NN
cord-306904-8iteddug	838	6	ELM	ELM	NNP
cord-306904-8iteddug	838	7	:	:	:
cord-306904-8iteddug	838	8	10	10	CD
cord-306904-8iteddug	838	9	years	year	NNS
cord-306904-8iteddug	838	10	and	and	CC
cord-306904-8iteddug	838	11	counting	count	VBG
cord-306904-8iteddug	838	12	Monomeric	Monomeric	NNP
cord-306904-8iteddug	838	13	TonB	TonB	NNP
cord-306904-8iteddug	838	14	and	and	CC
cord-306904-8iteddug	838	15	the	the	DT
cord-306904-8iteddug	838	16	Ton	Ton	NNP
cord-306904-8iteddug	838	17	box	box	NN
cord-306904-8iteddug	838	18	are	be	VBP
cord-306904-8iteddug	838	19	required	require	VBN
cord-306904-8iteddug	838	20	for	for	IN
cord-306904-8iteddug	838	21	the	the	DT
cord-306904-8iteddug	838	22	formation	formation	NN
cord-306904-8iteddug	838	23	of	of	IN
cord-306904-8iteddug	838	24	a	a	DT
cord-306904-8iteddug	838	25	high	high	JJ
cord-306904-8iteddug	838	26	-	-	HYPH
cord-306904-8iteddug	838	27	affinity	affinity	NN
cord-306904-8iteddug	838	28	transporter	transporter	NN
cord-306904-8iteddug	838	29	-	-	HYPH
cord-306904-8iteddug	838	30	TonB	TonB	NNP
cord-306904-8iteddug	838	31	complex	complex	NN
cord-306904-8iteddug	839	1	The	the	DT
cord-306904-8iteddug	839	2	proline	proline	JJ
cord-306904-8iteddug	839	3	-	-	HYPH
cord-306904-8iteddug	839	4	rich	rich	JJ
cord-306904-8iteddug	839	5	domain	domain	NN
cord-306904-8iteddug	839	6	of	of	IN
cord-306904-8iteddug	839	7	TonB	TonB	NNP
cord-306904-8iteddug	839	8	possesses	possess	VBZ
cord-306904-8iteddug	839	9	an	an	DT
cord-306904-8iteddug	839	10	extended	extended	JJ
cord-306904-8iteddug	839	11	polyproline	polyproline	NN
cord-306904-8iteddug	839	12	II	ii	NN
cord-306904-8iteddug	839	13	-	-	HYPH
cord-306904-8iteddug	839	14	like	like	JJ
cord-306904-8iteddug	839	15	conformation	conformation	NN
cord-306904-8iteddug	839	16	of	of	IN
cord-306904-8iteddug	839	17	sufficient	sufficient	JJ
cord-306904-8iteddug	839	18	length	length	NN
cord-306904-8iteddug	839	19	to	to	TO
cord-306904-8iteddug	839	20	span	span	VB
cord-306904-8iteddug	839	21	the	the	DT
cord-306904-8iteddug	839	22	periplasm	periplasm	NN
cord-306904-8iteddug	839	23	of	of	IN
cord-306904-8iteddug	839	24	Gram	gram	NN
cord-306904-8iteddug	839	25	-	-	HYPH
cord-306904-8iteddug	839	26	negative	negative	JJ
cord-306904-8iteddug	839	27	bacteria	bacteria	NNS
cord-306904-8iteddug	839	28	Outer	outer	JJ
cord-306904-8iteddug	839	29	membrane	membrane	NN
cord-306904-8iteddug	839	30	active	active	JJ
cord-306904-8iteddug	839	31	transport	transport	NN
cord-306904-8iteddug	839	32	:	:	:
cord-306904-8iteddug	839	33	structure	structure	NN
cord-306904-8iteddug	839	34	of	of	IN
cord-306904-8iteddug	839	35	the	the	DT
cord-306904-8iteddug	839	36	BtuB	BtuB	NNP
cord-306904-8iteddug	839	37	:	:	:
cord-306904-8iteddug	840	1	TonB	TonB	NNP
cord-306904-8iteddug	840	2	complex	complex	JJ
cord-306904-8iteddug	840	3	Structure	Structure	NNP
cord-306904-8iteddug	840	4	of	of	IN
cord-306904-8iteddug	840	5	TonB	TonB	NNP
cord-306904-8iteddug	840	6	in	in	IN
cord-306904-8iteddug	840	7	complex	complex	NN
cord-306904-8iteddug	840	8	with	with	IN
cord-306904-8iteddug	840	9	FhuA	FhuA	NNP
cord-306904-8iteddug	841	1	,	,	,
cord-306904-8iteddug	841	2	E.	E.	NNP
cord-306904-8iteddug	841	3	coli	coli	VBZ
cord-306904-8iteddug	841	4	outer	outer	JJ
cord-306904-8iteddug	841	5	membrane	membrane	NN
cord-306904-8iteddug	841	6	receptor	receptor	NN
cord-306904-8iteddug	841	7	Structure	structure	NN
cord-306904-8iteddug	841	8	and	and	CC
cord-306904-8iteddug	841	9	function	function	NN
cord-306904-8iteddug	841	10	of	of	IN
cord-306904-8iteddug	841	11	human	human	JJ
cord-306904-8iteddug	841	12	DnaJ	DnaJ	NNP
cord-306904-8iteddug	841	13	homologue	homologue	NN
cord-306904-8iteddug	841	14	subfamily	subfamily	NN
cord-306904-8iteddug	842	1	a	a	DT
cord-306904-8iteddug	842	2	member	member	NN
cord-306904-8iteddug	842	3	1	1	CD
cord-306904-8iteddug	842	4	(	(	-LRB-
cord-306904-8iteddug	842	5	DNAJA1	DNAJA1	NNP
cord-306904-8iteddug	842	6	)	)	-RRB-
cord-306904-8iteddug	842	7	and	and	CC
cord-306904-8iteddug	842	8	its	-PRON-	PRP$
cord-306904-8iteddug	842	9	relationship	relationship	NN
cord-306904-8iteddug	842	10	to	to	IN
cord-306904-8iteddug	842	11	pancreatic	pancreatic	JJ
cord-306904-8iteddug	842	12	cancer	cancer	NN
cord-306904-8iteddug	842	13	Proteomic	Proteomic	NNP
cord-306904-8iteddug	842	14	analysis	analysis	NN
cord-306904-8iteddug	842	15	of	of	IN
cord-306904-8iteddug	842	16	chronic	chronic	JJ
cord-306904-8iteddug	842	17	pancreatitis	pancreatitis	NN
cord-306904-8iteddug	842	18	and	and	CC
cord-306904-8iteddug	842	19	pancreatic	pancreatic	JJ
cord-306904-8iteddug	842	20	adenocarcinoma	adenocarcinoma	NN
cord-306904-8iteddug	842	21	Structural	structural	JJ
cord-306904-8iteddug	842	22	basis	basis	NN
cord-306904-8iteddug	842	23	of	of	IN
cord-306904-8iteddug	842	24	multisite	multisite	JJ
cord-306904-8iteddug	842	25	single	single	RB
cord-306904-8iteddug	842	26	-	-	HYPH
cord-306904-8iteddug	842	27	stranded	strand	VBN
cord-306904-8iteddug	842	28	DNA	dna	NN
cord-306904-8iteddug	842	29	recognition	recognition	NN
cord-306904-8iteddug	842	30	and	and	CC
cord-306904-8iteddug	842	31	ACTA2	ACTA2	NNP
cord-306904-8iteddug	842	32	repression	repression	NN
cord-306904-8iteddug	842	33	by	by	IN
cord-306904-8iteddug	842	34	purine	purine	NN
cord-306904-8iteddug	842	35	-	-	HYPH
cord-306904-8iteddug	842	36	rich	rich	JJ
cord-306904-8iteddug	842	37	element	element	NN
cord-306904-8iteddug	842	38	binding	bind	VBG
cord-306904-8iteddug	842	39	protein	protein	NN
cord-306904-8iteddug	842	40	B	b	NN
cord-306904-8iteddug	842	41	(	(	-LRB-
cord-306904-8iteddug	842	42	Purbeta	Purbeta	NNP
cord-306904-8iteddug	842	43	)	)	-RRB-
cord-306904-8iteddug	842	44	The	the	DT
cord-306904-8iteddug	842	45	HeLa	HeLa	NNP
cord-306904-8iteddug	842	46	Pur	Pur	NNP
cord-306904-8iteddug	842	47	factor	factor	NN
cord-306904-8iteddug	842	48	binds	bind	VBZ
cord-306904-8iteddug	842	49	single	single	RB
cord-306904-8iteddug	842	50	-	-	HYPH
cord-306904-8iteddug	842	51	stranded	strand	VBN
cord-306904-8iteddug	842	52	DNA	dna	NN
cord-306904-8iteddug	842	53	at	at	IN
cord-306904-8iteddug	842	54	a	a	DT
cord-306904-8iteddug	842	55	specific	specific	JJ
cord-306904-8iteddug	842	56	element	element	NN
cord-306904-8iteddug	842	57	conserved	conserve	VBN
cord-306904-8iteddug	842	58	in	in	IN
cord-306904-8iteddug	842	59	gene	gene	NN
cord-306904-8iteddug	842	60	flanking	flank	VBG
cord-306904-8iteddug	842	61	regions	region	NNS
cord-306904-8iteddug	842	62	and	and	CC
cord-306904-8iteddug	842	63	origins	origin	NNS
cord-306904-8iteddug	842	64	of	of	IN
cord-306904-8iteddug	842	65	DNA	dna	NN
cord-306904-8iteddug	842	66	replication	replication	NN
cord-306904-8iteddug	842	67	Sequence	sequence	NN
cord-306904-8iteddug	842	68	of	of	IN
cord-306904-8iteddug	842	69	cDNA	cdna	NN
cord-306904-8iteddug	842	70	comprising	comprise	VBG
cord-306904-8iteddug	842	71	the	the	DT
cord-306904-8iteddug	842	72	human	human	JJ
cord-306904-8iteddug	842	73	pur	pur	NN
cord-306904-8iteddug	842	74	gene	gene	NN
cord-306904-8iteddug	842	75	and	and	CC
cord-306904-8iteddug	842	76	sequencespecific	sequencespecific	NNP
cord-306904-8iteddug	842	77	single	single	RB
cord-306904-8iteddug	842	78	-	-	HYPH
cord-306904-8iteddug	842	79	stranded	strand	VBN
cord-306904-8iteddug	842	80	-	-	HYPH
cord-306904-8iteddug	842	81	DNA	dna	NN
cord-306904-8iteddug	842	82	-	-	HYPH
cord-306904-8iteddug	842	83	binding	bind	VBG
cord-306904-8iteddug	842	84	properties	property	NNS
cord-306904-8iteddug	842	85	of	of	IN
cord-306904-8iteddug	842	86	the	the	DT
cord-306904-8iteddug	842	87	encoded	encode	VBN
cord-306904-8iteddug	842	88	protein	protein	NN
cord-306904-8iteddug	842	89	The	the	DT
cord-306904-8iteddug	842	90	pur	pur	NNP
cord-306904-8iteddug	842	91	protein	protein	NN
cord-306904-8iteddug	842	92	family	family	NN
cord-306904-8iteddug	842	93	:	:	:
cord-306904-8iteddug	843	1	genetic	genetic	JJ
cord-306904-8iteddug	843	2	and	and	CC
cord-306904-8iteddug	843	3	structural	structural	JJ
cord-306904-8iteddug	843	4	features	feature	NNS
cord-306904-8iteddug	843	5	in	in	IN
cord-306904-8iteddug	843	6	development	development	NN
cord-306904-8iteddug	843	7	and	and	CC
cord-306904-8iteddug	843	8	disease	disease	NN
cord-306904-8iteddug	843	9	Emerging	Emerging	NNP
cord-306904-8iteddug	843	10	role	role	NN
cord-306904-8iteddug	843	11	of	of	IN
cord-306904-8iteddug	843	12	the	the	DT
cord-306904-8iteddug	843	13	host	host	NN
cord-306904-8iteddug	843	14	restriction	restriction	NN
cord-306904-8iteddug	843	15	factor	factor	NN
cord-306904-8iteddug	843	16	tetherin	tetherin	XX
cord-306904-8iteddug	843	17	in	in	IN
cord-306904-8iteddug	843	18	viral	viral	JJ
cord-306904-8iteddug	843	19	immune	immune	NN
cord-306904-8iteddug	843	20	sensing	sensing	NN
cord-306904-8iteddug	843	21	Bst-2	Bst-2	NNP
cord-306904-8iteddug	843	22	/	/	SYM
cord-306904-8iteddug	843	23	HM1.24	HM1.24	NNP
cord-306904-8iteddug	843	24	is	be	VBZ
cord-306904-8iteddug	843	25	a	a	DT
cord-306904-8iteddug	843	26	raft	raft	NN
cord-306904-8iteddug	843	27	-	-	HYPH
cord-306904-8iteddug	843	28	associated	associate	VBN
cord-306904-8iteddug	843	29	apical	apical	JJ
cord-306904-8iteddug	843	30	membrane	membrane	NN
cord-306904-8iteddug	843	31	protein	protein	NN
cord-306904-8iteddug	843	32	with	with	IN
cord-306904-8iteddug	843	33	an	an	DT
cord-306904-8iteddug	843	34	unusual	unusual	JJ
cord-306904-8iteddug	843	35	topology	topology	NN
cord-306904-8iteddug	843	36	Structural	structural	JJ
cord-306904-8iteddug	843	37	and	and	CC
cord-306904-8iteddug	843	38	biophysical	biophysical	JJ
cord-306904-8iteddug	843	39	analysis	analysis	NN
cord-306904-8iteddug	843	40	of	of	IN
cord-306904-8iteddug	843	41	BST-2	BST-2	NNP
cord-306904-8iteddug	843	42	/	/	SYM
cord-306904-8iteddug	843	43	tetherin	tetherin	NNP
cord-306904-8iteddug	843	44	ectodomains	ectodomains	NNP
cord-306904-8iteddug	843	45	reveals	reveal	VBZ
cord-306904-8iteddug	843	46	an	an	DT
cord-306904-8iteddug	843	47	evolutionary	evolutionary	JJ
cord-306904-8iteddug	843	48	conserved	conserve	VBN
cord-306904-8iteddug	843	49	design	design	NN
cord-306904-8iteddug	843	50	to	to	TO
cord-306904-8iteddug	843	51	inhibit	inhibit	VB
cord-306904-8iteddug	843	52	virus	virus	NN
cord-306904-8iteddug	843	53	release	release	NN
cord-306904-8iteddug	843	54	Running	run	VBG
cord-306904-8iteddug	843	55	in	in	IN
cord-306904-8iteddug	843	56	reverse	reverse	NN
cord-306904-8iteddug	843	57	:	:	:
cord-306904-8iteddug	843	58	the	the	DT
cord-306904-8iteddug	843	59	structural	structural	JJ
cord-306904-8iteddug	843	60	basis	basis	NN
cord-306904-8iteddug	843	61	for	for	IN
cord-306904-8iteddug	843	62	translocation	translocation	NN
cord-306904-8iteddug	843	63	polarity	polarity	NN
cord-306904-8iteddug	843	64	in	in	IN
cord-306904-8iteddug	843	65	hexameric	hexameric	JJ
cord-306904-8iteddug	843	66	helicases	helicase	NNS
cord-306904-8iteddug	844	1	Immunoelectron	immunoelectron	DT
cord-306904-8iteddug	844	2	microscopic	microscopic	JJ
cord-306904-8iteddug	844	3	evidence	evidence	NN
cord-306904-8iteddug	844	4	for	for	IN
cord-306904-8iteddug	844	5	Tetherin	Tetherin	NNP
cord-306904-8iteddug	844	6	/	/	SYM
cord-306904-8iteddug	844	7	BST2	BST2	NNP
cord-306904-8iteddug	844	8	as	as	IN
cord-306904-8iteddug	844	9	the	the	DT
cord-306904-8iteddug	844	10	physical	physical	JJ
cord-306904-8iteddug	844	11	bridge	bridge	NN
cord-306904-8iteddug	844	12	between	between	IN
cord-306904-8iteddug	844	13	HIV-1	HIV-1	NNP
cord-306904-8iteddug	844	14	virions	virion	NNS
cord-306904-8iteddug	844	15	and	and	CC
cord-306904-8iteddug	844	16	the	the	DT
cord-306904-8iteddug	844	17	plasma	plasma	NN
cord-306904-8iteddug	844	18	membrane	membrane	NN
cord-306904-8iteddug	844	19	Intrinsic	intrinsic	JJ
cord-306904-8iteddug	844	20	disorder	disorder	NN
cord-306904-8iteddug	844	21	of	of	IN
cord-306904-8iteddug	844	22	the	the	DT
cord-306904-8iteddug	844	23	extracellular	extracellular	JJ
cord-306904-8iteddug	844	24	matrix	matrix	NN
cord-306904-8iteddug	844	25	Assembly	Assembly	NNP
cord-306904-8iteddug	844	26	,	,	,
cord-306904-8iteddug	844	27	activation	activation	NN
cord-306904-8iteddug	844	28	,	,	,
cord-306904-8iteddug	844	29	and	and	CC
cord-306904-8iteddug	844	30	substrate	substrate	NN
cord-306904-8iteddug	844	31	specificity	specificity	NN
cord-306904-8iteddug	844	32	of	of	IN
cord-306904-8iteddug	844	33	cyclin	cyclin	NN
cord-306904-8iteddug	844	34	D1	D1	NNP
cord-306904-8iteddug	844	35	/	/	SYM
cord-306904-8iteddug	844	36	Cdk2	Cdk2	NNP
cord-306904-8iteddug	844	37	complexes	complex	NNS
cord-306904-8iteddug	844	38	Interactions	Interactions	NNPS
cord-306904-8iteddug	844	39	of	of	IN
cord-306904-8iteddug	844	40	apolipoprotein	apolipoprotein	NN
cord-306904-8iteddug	844	41	A	a	NN
cord-306904-8iteddug	845	1	-I	-I	NFP
cord-306904-8iteddug	845	2	with	with	IN
cord-306904-8iteddug	845	3	high	high	JJ
cord-306904-8iteddug	845	4	-	-	HYPH
cord-306904-8iteddug	845	5	density	density	NN
cord-306904-8iteddug	845	6	lipoprotein	lipoprotein	NN
cord-306904-8iteddug	845	7	particles	particle	NNS
cord-306904-8iteddug	846	1	The	the	DT
cord-306904-8iteddug	846	2	structure	structure	NN
cord-306904-8iteddug	846	3	of	of	IN
cord-306904-8iteddug	846	4	human	human	JJ
cord-306904-8iteddug	846	5	lipoprotein	lipoprotein	NN
cord-306904-8iteddug	846	6	A	A	NNP
cord-306904-8iteddug	846	7	-	-	HYPH
cord-306904-8iteddug	846	8	I.	i.	NN
cord-306904-8iteddug	846	9	Evidence	evidence	NN
cord-306904-8iteddug	846	10	for	for	IN
cord-306904-8iteddug	846	11	the	the	DT
cord-306904-8iteddug	846	12	"	"	``
cord-306904-8iteddug	846	13	belt	belt	NN
cord-306904-8iteddug	846	14	"	"	''
cord-306904-8iteddug	846	15	model	model	NN
cord-306904-8iteddug	846	16	A	a	DT
cord-306904-8iteddug	846	17	detailed	detailed	JJ
cord-306904-8iteddug	846	18	molecular	molecular	JJ
cord-306904-8iteddug	846	19	belt	belt	NN
cord-306904-8iteddug	846	20	model	model	NN
cord-306904-8iteddug	846	21	for	for	IN
cord-306904-8iteddug	846	22	apolipoprotein	apolipoprotein	NNP
cord-306904-8iteddug	846	23	A	A	NNP
cord-306904-8iteddug	846	24	-	-	:
cord-306904-8iteddug	846	25	I	-PRON-	PRP
cord-306904-8iteddug	846	26	in	in	IN
cord-306904-8iteddug	846	27	discoidal	discoidal	JJ
cord-306904-8iteddug	846	28	high	high	JJ
cord-306904-8iteddug	846	29	density	density	NN
cord-306904-8iteddug	846	30	lipoprotein	lipoprotein	NN
cord-306904-8iteddug	846	31	High	high	JJ
cord-306904-8iteddug	846	32	density	density	NN
cord-306904-8iteddug	846	33	lipoprotein	lipoprotein	NN
cord-306904-8iteddug	846	34	structure	structure	NN
cord-306904-8iteddug	846	35	-	-	HYPH
cord-306904-8iteddug	846	36	function	function	NN
cord-306904-8iteddug	846	37	and	and	CC
cord-306904-8iteddug	846	38	role	role	NN
cord-306904-8iteddug	846	39	in	in	IN
cord-306904-8iteddug	846	40	reverse	reverse	JJ
cord-306904-8iteddug	846	41	cholesterol	cholesterol	NN
cord-306904-8iteddug	846	42	transport	transport	NN
cord-306904-8iteddug	846	43	High	high	JJ
cord-306904-8iteddug	846	44	-	-	HYPH
cord-306904-8iteddug	846	45	density	density	NN
cord-306904-8iteddug	846	46	lipoprotein	lipoprotein	NN
cord-306904-8iteddug	846	47	heterogeneity	heterogeneity	NN
cord-306904-8iteddug	846	48	and	and	CC
cord-306904-8iteddug	846	49	function	function	VB
cord-306904-8iteddug	846	50	in	in	IN
cord-306904-8iteddug	846	51	reverse	reverse	JJ
cord-306904-8iteddug	846	52	cholesterol	cholesterol	NN
cord-306904-8iteddug	846	53	transport	transport	NN
cord-306904-8iteddug	846	54	Double	double	JJ
cord-306904-8iteddug	846	55	superhelix	superhelix	JJ
cord-306904-8iteddug	846	56	model	model	NN
cord-306904-8iteddug	846	57	of	of	IN
cord-306904-8iteddug	846	58	high	high	JJ
cord-306904-8iteddug	846	59	density	density	NN
cord-306904-8iteddug	846	60	lipoprotein	lipoprotein	NN
cord-306904-8iteddug	846	61	Analysis	Analysis	NNP
cord-306904-8iteddug	846	62	of	of	IN
cord-306904-8iteddug	846	63	ordered	order	VBN
cord-306904-8iteddug	846	64	and	and	CC
cord-306904-8iteddug	846	65	disordered	disordered	JJ
cord-306904-8iteddug	846	66	protein	protein	NN
cord-306904-8iteddug	846	67	complexes	complex	NNS
cord-306904-8iteddug	846	68	reveals	reveal	VBZ
cord-306904-8iteddug	846	69	structural	structural	JJ
cord-306904-8iteddug	846	70	features	feature	NNS
cord-306904-8iteddug	846	71	discriminating	discriminate	VBG
cord-306904-8iteddug	846	72	between	between	IN
cord-306904-8iteddug	846	73	stable	stable	JJ
cord-306904-8iteddug	846	74	and	and	CC
cord-306904-8iteddug	846	75	unstable	unstable	JJ
cord-306904-8iteddug	846	76	monomers	monomer	NNS
cord-306904-8iteddug	846	77	Mechanisms	Mechanisms	NNPS
cord-306904-8iteddug	846	78	of	of	IN
cord-306904-8iteddug	846	79	MAVS	MAVS	NNP
cord-306904-8iteddug	846	80	regulation	regulation	NN
cord-306904-8iteddug	846	81	at	at	IN
cord-306904-8iteddug	846	82	the	the	DT
cord-306904-8iteddug	846	83	mitochondrial	mitochondrial	JJ
cord-306904-8iteddug	846	84	membrane	membrane	NN
cord-306904-8iteddug	847	1	Reconstituted	reconstitute	VBN
cord-306904-8iteddug	847	2	human	human	JJ
cord-306904-8iteddug	847	3	myosin	myosin	NN
cord-306904-8iteddug	847	4	light	light	NN
cord-306904-8iteddug	847	5	chain	chain	NN
cord-306904-8iteddug	847	6	phosphatase	phosphatase	NN
cord-306904-8iteddug	847	7	reveals	reveal	VBZ
cord-306904-8iteddug	847	8	distinct	distinct	JJ
cord-306904-8iteddug	847	9	roles	role	NNS
cord-306904-8iteddug	847	10	of	of	IN
cord-306904-8iteddug	847	11	two	two	CD
cord-306904-8iteddug	847	12	inhibitory	inhibitory	JJ
cord-306904-8iteddug	847	13	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	847	14	sites	site	NNS
cord-306904-8iteddug	847	15	of	of	IN
cord-306904-8iteddug	847	16	the	the	DT
cord-306904-8iteddug	847	17	regulatory	regulatory	JJ
cord-306904-8iteddug	847	18	subunit	subunit	NN
cord-306904-8iteddug	847	19	,	,	,
cord-306904-8iteddug	847	20	MYPT1	MYPT1	NNP
cord-306904-8iteddug	847	21	Structural	structural	JJ
cord-306904-8iteddug	847	22	and	and	CC
cord-306904-8iteddug	847	23	functional	functional	JJ
cord-306904-8iteddug	847	24	analysis	analysis	NN
cord-306904-8iteddug	847	25	of	of	IN
cord-306904-8iteddug	847	26	the	the	DT
cord-306904-8iteddug	847	27	GerD	GerD	NNP
cord-306904-8iteddug	847	28	spore	spore	NN
cord-306904-8iteddug	847	29	germination	germination	NN
cord-306904-8iteddug	847	30	protein	protein	NN
cord-306904-8iteddug	847	31	of	of	IN
cord-306904-8iteddug	847	32	Bacillus	Bacillus	NNP
cord-306904-8iteddug	847	33	species	specie	VBZ
cord-306904-8iteddug	847	34	Spores	spore	NNS
cord-306904-8iteddug	847	35	of	of	IN
cord-306904-8iteddug	847	36	Bacillus	bacillus	NN
cord-306904-8iteddug	847	37	subtilis	subtili	NNS
cord-306904-8iteddug	847	38	:	:	:
cord-306904-8iteddug	847	39	their	-PRON-	PRP$
cord-306904-8iteddug	847	40	resistance	resistance	NN
cord-306904-8iteddug	847	41	to	to	IN
cord-306904-8iteddug	847	42	and	and	CC
cord-306904-8iteddug	847	43	killing	kill	VBG
cord-306904-8iteddug	847	44	by	by	IN
cord-306904-8iteddug	847	45	radiation	radiation	NN
cord-306904-8iteddug	847	46	,	,	,
cord-306904-8iteddug	847	47	heat	heat	NN
cord-306904-8iteddug	847	48	and	and	CC
cord-306904-8iteddug	847	49	chemicals	chemical	NNS
cord-306904-8iteddug	847	50	Germination	germination	NN
cord-306904-8iteddug	847	51	of	of	IN
cord-306904-8iteddug	847	52	spores	spore	NNS
cord-306904-8iteddug	847	53	of	of	IN
cord-306904-8iteddug	847	54	Bacillales	Bacillales	NNP
cord-306904-8iteddug	847	55	and	and	CC
cord-306904-8iteddug	847	56	Clostridiales	Clostridiales	NNP
cord-306904-8iteddug	847	57	species	specie	NNS
cord-306904-8iteddug	847	58	:	:	:
cord-306904-8iteddug	847	59	mechanisms	mechanism	NNS
cord-306904-8iteddug	847	60	and	and	CC
cord-306904-8iteddug	847	61	proteins	protein	NNS
cord-306904-8iteddug	847	62	involved	involve	VBD
cord-306904-8iteddug	847	63	Spore	Spore	NNP
cord-306904-8iteddug	847	64	germination	germination	NN
cord-306904-8iteddug	847	65	How	how	WRB
cord-306904-8iteddug	847	66	do	do	VBP
cord-306904-8iteddug	847	67	spores	spore	NNS
cord-306904-8iteddug	847	68	germinate	germinate	VB
cord-306904-8iteddug	847	69	?	?	.
cord-306904-8iteddug	848	1	The	the	DT
cord-306904-8iteddug	848	2	Ger	Ger	NNP
cord-306904-8iteddug	848	3	receptor	receptor	NN
cord-306904-8iteddug	848	4	family	family	NN
cord-306904-8iteddug	848	5	from	from	IN
cord-306904-8iteddug	848	6	sporulating	sporulate	VBG
cord-306904-8iteddug	848	7	bacteria	bacteria	NNS
cord-306904-8iteddug	848	8	Bacterial	bacterial	JJ
cord-306904-8iteddug	848	9	proteasome	proteasome	NN
cord-306904-8iteddug	848	10	and	and	CC
cord-306904-8iteddug	848	11	PafA	PafA	NNP
cord-306904-8iteddug	848	12	,	,	,
cord-306904-8iteddug	848	13	the	the	DT
cord-306904-8iteddug	848	14	pup	pup	NN
cord-306904-8iteddug	848	15	ligase	ligase	NN
cord-306904-8iteddug	848	16	,	,	,
cord-306904-8iteddug	848	17	interact	interact	VB
cord-306904-8iteddug	848	18	to	to	TO
cord-306904-8iteddug	848	19	form	form	VB
cord-306904-8iteddug	848	20	a	a	DT
cord-306904-8iteddug	848	21	modular	modular	JJ
cord-306904-8iteddug	848	22	protein	protein	NN
cord-306904-8iteddug	848	23	tagging	tagging	NN
cord-306904-8iteddug	848	24	and	and	CC
cord-306904-8iteddug	848	25	degradation	degradation	NN
cord-306904-8iteddug	848	26	machine	machine	NN
cord-306904-8iteddug	849	1	The	the	DT
cord-306904-8iteddug	849	2	nucleolar	nucleolar	JJ
cord-306904-8iteddug	849	3	PICT-1	PICT-1	NNP
cord-306904-8iteddug	849	4	/	/	SYM
cord-306904-8iteddug	849	5	GLTSCR2	GLTSCR2	NNP
cord-306904-8iteddug	849	6	protein	protein	NN
cord-306904-8iteddug	849	7	forms	form	NNS
cord-306904-8iteddug	849	8	homo	homo	NN
cord-306904-8iteddug	849	9	-	-	HYPH
cord-306904-8iteddug	849	10	oligomers	oligomer	NNS
cord-306904-8iteddug	849	11	Regulation	regulation	NN
cord-306904-8iteddug	849	12	of	of	IN
cord-306904-8iteddug	849	13	the	the	DT
cord-306904-8iteddug	849	14	MDM2-P53	MDM2-P53	NNP
cord-306904-8iteddug	849	15	pathway	pathway	NN
cord-306904-8iteddug	849	16	and	and	CC
cord-306904-8iteddug	849	17	tumor	tumor	NN
cord-306904-8iteddug	849	18	growth	growth	NN
cord-306904-8iteddug	849	19	by	by	IN
cord-306904-8iteddug	849	20	PICT1	pict1	NN
cord-306904-8iteddug	849	21	via	via	IN
cord-306904-8iteddug	849	22	nucleolar	nucleolar	JJ
cord-306904-8iteddug	849	23	RPL11	RPL11	NNP
cord-306904-8iteddug	849	24	Regulation	regulation	NN
cord-306904-8iteddug	849	25	of	of	IN
cord-306904-8iteddug	849	26	PTEN	PTEN	NNP
cord-306904-8iteddug	849	27	phosphorylation	phosphorylation	NN
cord-306904-8iteddug	849	28	and	and	CC
cord-306904-8iteddug	849	29	stability	stability	NN
cord-306904-8iteddug	849	30	by	by	IN
cord-306904-8iteddug	849	31	a	a	DT
cord-306904-8iteddug	849	32	tumor	tumor	NN
cord-306904-8iteddug	849	33	suppressor	suppressor	NN
cord-306904-8iteddug	849	34	candidate	candidate	NN
cord-306904-8iteddug	849	35	protein	protein	NN
cord-306904-8iteddug	849	36	Amino	amino	NN
cord-306904-8iteddug	849	37	acid	acid	NN
cord-306904-8iteddug	849	38	signature	signature	NN
cord-306904-8iteddug	849	39	enables	enable	VBZ
cord-306904-8iteddug	849	40	proteins	protein	NNS
cord-306904-8iteddug	849	41	to	to	TO
cord-306904-8iteddug	849	42	recognize	recognize	VB
cord-306904-8iteddug	849	43	modified	modify	VBN
cord-306904-8iteddug	849	44	tRNA	tRNA	NNP
cord-306904-8iteddug	849	45	Human	Human	NNP
cord-306904-8iteddug	849	46	tRNA(Lys3)(UUU	tRNA(Lys3)(UUU	NNP
cord-306904-8iteddug	849	47	)	)	-RRB-
cord-306904-8iteddug	849	48	is	be	VBZ
cord-306904-8iteddug	849	49	pre	pre	JJ
cord-306904-8iteddug	849	50	-	-	JJ
cord-306904-8iteddug	849	51	structured	structure	VBN
cord-306904-8iteddug	849	52	by	by	IN
cord-306904-8iteddug	849	53	natural	natural	JJ
cord-306904-8iteddug	849	54	modifications	modification	NNS
cord-306904-8iteddug	849	55	for	for	IN
cord-306904-8iteddug	849	56	cognate	cognate	NN
cord-306904-8iteddug	849	57	and	and	CC
cord-306904-8iteddug	850	1	wobble	wobble	VB
cord-306904-8iteddug	850	2	codon	codon	NN
cord-306904-8iteddug	850	3	binding	bind	VBG
cord-306904-8iteddug	850	4	through	through	IN
cord-306904-8iteddug	850	5	keto	keto	NNP
cord-306904-8iteddug	850	6	-	-	HYPH
cord-306904-8iteddug	850	7	enol	enol	NNP
cord-306904-8iteddug	850	8	tautomerism	tautomerism	NNP
cord-306904-8iteddug	850	9	Mutations	Mutations	NNPS
cord-306904-8iteddug	850	10	of	of	IN
cord-306904-8iteddug	850	11	basic	basic	JJ
cord-306904-8iteddug	850	12	amino	amino	NN
cord-306904-8iteddug	850	13	acids	acid	NNS
cord-306904-8iteddug	850	14	of	of	IN
cord-306904-8iteddug	850	15	NCp7	ncp7	NN
cord-306904-8iteddug	850	16	of	of	IN
cord-306904-8iteddug	850	17	human	human	JJ
cord-306904-8iteddug	850	18	immunodeficiency	immunodeficiency	NN
cord-306904-8iteddug	850	19	virus	virus	NN
cord-306904-8iteddug	850	20	type	type	NN
cord-306904-8iteddug	850	21	1	1	CD
cord-306904-8iteddug	850	22	affect	affect	NN
cord-306904-8iteddug	850	23	RNA	RNA	NNP
cord-306904-8iteddug	850	24	binding	bind	VBG
cord-306904-8iteddug	850	25	in	in	IN
cord-306904-8iteddug	850	26	vitro	vitro	FW
cord-306904-8iteddug	850	27	Charged	charge	VBN
cord-306904-8iteddug	850	28	amino	amino	NN
cord-306904-8iteddug	850	29	acid	acid	NN
cord-306904-8iteddug	850	30	residues	residue	NNS
cord-306904-8iteddug	850	31	of	of	IN
cord-306904-8iteddug	850	32	human	human	JJ
cord-306904-8iteddug	850	33	immunodeficiency	immunodeficiency	NN
cord-306904-8iteddug	850	34	virus	virus	NN
cord-306904-8iteddug	850	35	type	type	NN
cord-306904-8iteddug	850	36	1	1	CD
cord-306904-8iteddug	850	37	nucleocapsid	nucleocapsid	NN
cord-306904-8iteddug	850	38	p7	p7	IN
cord-306904-8iteddug	850	39	protein	protein	NN
cord-306904-8iteddug	850	40	involved	involve	VBN
cord-306904-8iteddug	850	41	in	in	IN
cord-306904-8iteddug	850	42	RNA	RNA	NNP
cord-306904-8iteddug	850	43	packaging	packaging	NN
cord-306904-8iteddug	850	44	and	and	CC
cord-306904-8iteddug	850	45	infectivity	infectivity	NN
cord-306904-8iteddug	850	46	HIV-1	HIV-1	NNP
cord-306904-8iteddug	850	47	:	:	:
cord-306904-8iteddug	850	48	fifteen	fifteen	CD
cord-306904-8iteddug	850	49	proteins	protein	NNS
cord-306904-8iteddug	850	50	and	and	CC
cord-306904-8iteddug	850	51	an	an	DT
cord-306904-8iteddug	850	52	RNA	RNA	NNP
cord-306904-8iteddug	850	53	Effect	effect	NN
cord-306904-8iteddug	850	54	of	of	IN
cord-306904-8iteddug	850	55	mutations	mutation	NNS
cord-306904-8iteddug	850	56	in	in	IN
cord-306904-8iteddug	850	57	the	the	DT
cord-306904-8iteddug	850	58	nucleocapsid	nucleocapsid	NNP
cord-306904-8iteddug	850	59	protein	protein	NNP
cord-306904-8iteddug	850	60	(	(	-LRB-
cord-306904-8iteddug	850	61	NCp7	NCp7	NNP
cord-306904-8iteddug	850	62	)	)	-RRB-
cord-306904-8iteddug	850	63	upon	upon	IN
cord-306904-8iteddug	850	64	Pr160(gagpol	Pr160(gagpol	NNP
cord-306904-8iteddug	850	65	)	)	-RRB-
cord-306904-8iteddug	851	1	and	and	CC
cord-306904-8iteddug	851	2	tRNA(Lys	tRNA(Lys	NNP
cord-306904-8iteddug	851	3	)	)	-RRB-
cord-306904-8iteddug	851	4	incorporation	incorporation	NN
cord-306904-8iteddug	851	5	into	into	IN
cord-306904-8iteddug	851	6	human	human	JJ
cord-306904-8iteddug	851	7	immunodeficiency	immunodeficiency	NN
cord-306904-8iteddug	851	8	virus	virus	NN
cord-306904-8iteddug	851	9	type	type	NN
cord-306904-8iteddug	851	10	1	1	CD
cord-306904-8iteddug	851	11	Human	Human	NNP
cord-306904-8iteddug	851	12	immunodeficiency	immunodeficiency	NN
cord-306904-8iteddug	851	13	virus	virus	NN
cord-306904-8iteddug	851	14	type	type	NN
cord-306904-8iteddug	851	15	1	1	CD
cord-306904-8iteddug	851	16	nucleocapsid	nucleocapsid	NN
cord-306904-8iteddug	851	17	protein	protein	NN
cord-306904-8iteddug	851	18	promotes	promote	VBZ
cord-306904-8iteddug	851	19	efficient	efficient	JJ
cord-306904-8iteddug	851	20	strand	strand	NN
cord-306904-8iteddug	851	21	transfer	transfer	NN
cord-306904-8iteddug	851	22	and	and	CC
cord-306904-8iteddug	851	23	specific	specific	JJ
cord-306904-8iteddug	851	24	viral	viral	JJ
cord-306904-8iteddug	851	25	DNA	dna	NN
cord-306904-8iteddug	851	26	synthesis	synthesis	NN
cord-306904-8iteddug	851	27	by	by	IN
cord-306904-8iteddug	851	28	inhibiting	inhibit	VBG
cord-306904-8iteddug	851	29	TAR	tar	NN
cord-306904-8iteddug	851	30	-	-	HYPH
cord-306904-8iteddug	851	31	dependent	dependent	JJ
cord-306904-8iteddug	851	32	self	self	NN
cord-306904-8iteddug	851	33	-	-	HYPH
cord-306904-8iteddug	851	34	priming	prime	VBG
cord-306904-8iteddug	851	35	from	from	IN
cord-306904-8iteddug	851	36	minus	minus	JJ
cord-306904-8iteddug	851	37	-	-	HYPH
cord-306904-8iteddug	851	38	strand	strand	NN
cord-306904-8iteddug	851	39	strong	strong	JJ
cord-306904-8iteddug	851	40	-	-	HYPH
cord-306904-8iteddug	851	41	stop	stop	NN
cord-306904-8iteddug	851	42	DNA	DNA	NNP
cord-306904-8iteddug	851	43	Mutations	Mutations	NNPS
cord-306904-8iteddug	851	44	in	in	IN
cord-306904-8iteddug	851	45	HIV	HIV	NNP
cord-306904-8iteddug	851	46	reverse	reverse	NN
cord-306904-8iteddug	851	47	transcriptase	transcriptase	NN
cord-306904-8iteddug	851	48	which	which	WDT
cord-306904-8iteddug	851	49	alter	alter	VBP
cord-306904-8iteddug	851	50	RNase	rnase	NN
cord-306904-8iteddug	851	51	H	h	NN
cord-306904-8iteddug	851	52	activity	activity	NN
cord-306904-8iteddug	851	53	and	and	CC
cord-306904-8iteddug	851	54	decrease	decrease	VB
cord-306904-8iteddug	851	55	strand	strand	NN
cord-306904-8iteddug	851	56	transfer	transfer	NN
cord-306904-8iteddug	851	57	efficiency	efficiency	NN
cord-306904-8iteddug	851	58	are	be	VBP
cord-306904-8iteddug	851	59	suppressed	suppress	VBN
cord-306904-8iteddug	851	60	by	by	IN
cord-306904-8iteddug	851	61	HIV	HIV	NNP
cord-306904-8iteddug	851	62	nucleocapsid	nucleocapsid	NNP
cord-306904-8iteddug	851	63	protein	protein	NN
cord-306904-8iteddug	851	64	Human	Human	NNP
cord-306904-8iteddug	851	65	immunodeficiency	immunodeficiency	NN
cord-306904-8iteddug	851	66	virus	virus	NN
cord-306904-8iteddug	851	67	type	type	NN
cord-306904-8iteddug	851	68	1	1	CD
cord-306904-8iteddug	851	69	nucleocapsid	nucleocapsid	NN
cord-306904-8iteddug	851	70	protein	protein	NN
cord-306904-8iteddug	851	71	specifically	specifically	RB
cord-306904-8iteddug	851	72	stimulates	stimulate	VBZ
cord-306904-8iteddug	851	73	Mg2C	mg2c	JJ
cord-306904-8iteddug	851	74	-	-	JJ
cord-306904-8iteddug	851	75	dependent	dependent	JJ
cord-306904-8iteddug	851	76	DNA	dna	NN
cord-306904-8iteddug	851	77	integration	integration	NN
cord-306904-8iteddug	851	78	in	in	IN
cord-306904-8iteddug	851	79	vitro	vitro	FW
cord-306904-8iteddug	851	80	Nucleocapsid	Nucleocapsid	NNP
cord-306904-8iteddug	851	81	zinc	zinc	NN
cord-306904-8iteddug	851	82	fingers	finger	NNS
cord-306904-8iteddug	851	83	detected	detect	VBN
cord-306904-8iteddug	851	84	in	in	IN
cord-306904-8iteddug	851	85	retroviruses	retrovirus	NNS
cord-306904-8iteddug	851	86	:	:	:
cord-306904-8iteddug	852	1	EXAFS	EXAFS	NNP
cord-306904-8iteddug	852	2	studies	study	NNS
cord-306904-8iteddug	852	3	of	of	IN
cord-306904-8iteddug	852	4	intact	intact	JJ
cord-306904-8iteddug	852	5	viruses	virus	NNS
cord-306904-8iteddug	852	6	and	and	CC
cord-306904-8iteddug	852	7	the	the	DT
cord-306904-8iteddug	852	8	solution	solution	NN
cord-306904-8iteddug	852	9	-	-	HYPH
cord-306904-8iteddug	852	10	state	state	NN
cord-306904-8iteddug	852	11	structure	structure	NN
cord-306904-8iteddug	852	12	of	of	IN
cord-306904-8iteddug	852	13	the	the	DT
cord-306904-8iteddug	852	14	nucleocapsid	nucleocapsid	NNP
cord-306904-8iteddug	852	15	protein	protein	NN
cord-306904-8iteddug	852	16	from	from	IN
cord-306904-8iteddug	852	17	HIV-1	HIV-1	NNP
cord-306904-8iteddug	852	18	Determination	Determination	NNP
cord-306904-8iteddug	852	19	of	of	IN
cord-306904-8iteddug	852	20	the	the	DT
cord-306904-8iteddug	852	21	structure	structure	NN
cord-306904-8iteddug	852	22	of	of	IN
cord-306904-8iteddug	852	23	the	the	DT
cord-306904-8iteddug	852	24	nucleocapsid	nucleocapsid	NNP
cord-306904-8iteddug	852	25	protein	protein	NN
cord-306904-8iteddug	852	26	NCp7	ncp7	NN
cord-306904-8iteddug	852	27	from	from	IN
cord-306904-8iteddug	852	28	the	the	DT
cord-306904-8iteddug	852	29	human	human	JJ
cord-306904-8iteddug	852	30	immunodeficiency	immunodeficiency	NN
cord-306904-8iteddug	852	31	virus	virus	NN
cord-306904-8iteddug	852	32	type	type	NN
cord-306904-8iteddug	852	33	1	1	CD
cord-306904-8iteddug	852	34	by	by	IN
cord-306904-8iteddug	852	35	1H	1h	CD
cord-306904-8iteddug	852	36	NMR	NMR	NNP
cord-306904-8iteddug	852	37	Protein	Protein	NNP
cord-306904-8iteddug	852	38	intrinsic	intrinsic	JJ
cord-306904-8iteddug	852	39	disorder	disorder	NN
cord-306904-8iteddug	852	40	as	as	IN
cord-306904-8iteddug	852	41	a	a	DT
cord-306904-8iteddug	852	42	flexible	flexible	JJ
cord-306904-8iteddug	852	43	armor	armor	NN
cord-306904-8iteddug	852	44	and	and	CC
cord-306904-8iteddug	852	45	a	a	DT
cord-306904-8iteddug	852	46	weapon	weapon	NN
cord-306904-8iteddug	852	47	of	of	IN
cord-306904-8iteddug	852	48	HIV-1	HIV-1	NNP