id	sid	tid	token	lemma	pos
cord-301128-woe6knpv	1	1	key	key	JJ
cord-301128-woe6knpv	2	1	:	:	:
cord-301128-woe6knpv	2	2	cord-301128-woe6knpv	cord-301128-woe6knpv	NN
cord-301128-woe6knpv	2	3	authors	author	NNS
cord-301128-woe6knpv	2	4	:	:	:
cord-301128-woe6knpv	3	1	Joyeux	Joyeux	NNP
cord-301128-woe6knpv	3	2	,	,	,
cord-301128-woe6knpv	3	3	Marc	Marc	NNP
cord-301128-woe6knpv	3	4	title	title	NN
cord-301128-woe6knpv	3	5	:	:	:
cord-301128-woe6knpv	3	6	Requirements	requirement	NNS
cord-301128-woe6knpv	3	7	for	for	IN
cord-301128-woe6knpv	3	8	DNA	dna	NN
cord-301128-woe6knpv	3	9	-	-	HYPH
cord-301128-woe6knpv	3	10	bridging	bridge	VBG
cord-301128-woe6knpv	3	11	proteins	protein	NNS
cord-301128-woe6knpv	3	12	to	to	TO
cord-301128-woe6knpv	3	13	act	act	VB
cord-301128-woe6knpv	3	14	as	as	IN
cord-301128-woe6knpv	3	15	topological	topological	JJ
cord-301128-woe6knpv	3	16	barriers	barrier	NNS
cord-301128-woe6knpv	3	17	of	of	IN
cord-301128-woe6knpv	3	18	the	the	DT
cord-301128-woe6knpv	3	19	bacterial	bacterial	JJ
cord-301128-woe6knpv	3	20	genome	genome	NN
cord-301128-woe6knpv	3	21	date	date	NN
cord-301128-woe6knpv	3	22	:	:	:
cord-301128-woe6knpv	3	23	2020	2020	CD
cord-301128-woe6knpv	3	24	-	-	HYPH
cord-301128-woe6knpv	3	25	08	08	CD
cord-301128-woe6knpv	3	26	-	-	SYM
cord-301128-woe6knpv	3	27	12	12	CD
cord-301128-woe6knpv	3	28	journal	journal	NN
cord-301128-woe6knpv	3	29	:	:	:
cord-301128-woe6knpv	4	1	Biophys	Biophys	NNP
cord-301128-woe6knpv	4	2	J	J	NNP
cord-301128-woe6knpv	4	3	DOI	DOI	NNP
cord-301128-woe6knpv	4	4	:	:	:
cord-301128-woe6knpv	4	5	10.1016	10.1016	CD
cord-301128-woe6knpv	4	6	/	/	SYM
cord-301128-woe6knpv	4	7	j.bpj.2020.08.004	j.bpj.2020.08.004	NN
cord-301128-woe6knpv	4	8	sha	sha	NN
cord-301128-woe6knpv	4	9	:	:	:
cord-301128-woe6knpv	5	1	2b64380ac3f927f80b9bfcf798ca419f5a6b2b55	2b64380ac3f927f80b9bfcf798ca419f5a6b2b55	CD
cord-301128-woe6knpv	6	1	doc_id	doc_id	CD
cord-301128-woe6knpv	7	1	:	:	:
cord-301128-woe6knpv	7	2	301128	301128	CD
cord-301128-woe6knpv	7	3	cord_uid	cord_uid	NNS
cord-301128-woe6knpv	7	4	:	:	:
cord-301128-woe6knpv	8	1	woe6knpv	woe6knpv	NNP
cord-301128-woe6knpv	8	2	Abstract	Abstract	NNP
cord-301128-woe6knpv	8	3	Bacterial	bacterial	JJ
cord-301128-woe6knpv	8	4	genomes	genome	NNS
cord-301128-woe6knpv	8	5	have	have	VBP
cord-301128-woe6knpv	8	6	been	be	VBN
cord-301128-woe6knpv	8	7	shown	show	VBN
cord-301128-woe6knpv	8	8	to	to	TO
cord-301128-woe6knpv	8	9	be	be	VB
cord-301128-woe6knpv	8	10	partitioned	partition	VBN
cord-301128-woe6knpv	8	11	into	into	IN
cord-301128-woe6knpv	8	12	several	several	JJ
cord-301128-woe6knpv	8	13	kilobases	kilobase	NNS
cord-301128-woe6knpv	8	14	long	long	JJ
cord-301128-woe6knpv	8	15	chromosomal	chromosomal	JJ
cord-301128-woe6knpv	8	16	domains	domain	NNS
cord-301128-woe6knpv	8	17	that	that	WDT
cord-301128-woe6knpv	8	18	are	be	VBP
cord-301128-woe6knpv	8	19	topologically	topologically	RB
cord-301128-woe6knpv	8	20	independent	independent	JJ
cord-301128-woe6knpv	8	21	from	from	IN
cord-301128-woe6knpv	8	22	each	each	DT
cord-301128-woe6knpv	8	23	other	other	JJ
cord-301128-woe6knpv	8	24	,	,	,
cord-301128-woe6knpv	8	25	meaning	mean	VBG
cord-301128-woe6knpv	8	26	that	that	IN
cord-301128-woe6knpv	8	27	change	change	NN
cord-301128-woe6knpv	8	28	of	of	IN
cord-301128-woe6knpv	8	29	DNA	dna	NN
cord-301128-woe6knpv	8	30	superhelicity	superhelicity	NN
cord-301128-woe6knpv	8	31	in	in	IN
cord-301128-woe6knpv	8	32	one	one	CD
cord-301128-woe6knpv	8	33	domain	domain	NN
cord-301128-woe6knpv	8	34	does	do	VBZ
cord-301128-woe6knpv	8	35	not	not	RB
cord-301128-woe6knpv	8	36	propagate	propagate	VB
cord-301128-woe6knpv	8	37	to	to	IN
cord-301128-woe6knpv	8	38	neighbors	neighbor	NNS
cord-301128-woe6knpv	8	39	.	.	.
cord-301128-woe6knpv	9	1	Both	both	DT
cord-301128-woe6knpv	9	2	in	in	IN
cord-301128-woe6knpv	9	3	vivo	vivo	NN
cord-301128-woe6knpv	9	4	and	and	CC
cord-301128-woe6knpv	9	5	in	in	IN
cord-301128-woe6knpv	9	6	vitro	vitro	FW
cord-301128-woe6knpv	9	7	experiments	experiment	NNS
cord-301128-woe6knpv	9	8	have	have	VBP
cord-301128-woe6knpv	9	9	been	be	VBN
cord-301128-woe6knpv	9	10	performed	perform	VBN
cord-301128-woe6knpv	9	11	to	to	TO
cord-301128-woe6knpv	9	12	question	question	VB
cord-301128-woe6knpv	9	13	the	the	DT
cord-301128-woe6knpv	9	14	nature	nature	NN
cord-301128-woe6knpv	9	15	of	of	IN
cord-301128-woe6knpv	9	16	the	the	DT
cord-301128-woe6knpv	9	17	topological	topological	JJ
cord-301128-woe6knpv	9	18	barriers	barrier	NNS
cord-301128-woe6knpv	9	19	at	at	IN
cord-301128-woe6knpv	9	20	play	play	NN
cord-301128-woe6knpv	9	21	,	,	,
cord-301128-woe6knpv	9	22	leading	lead	VBG
cord-301128-woe6knpv	9	23	to	to	IN
cord-301128-woe6knpv	9	24	several	several	JJ
cord-301128-woe6knpv	9	25	predictions	prediction	NNS
cord-301128-woe6knpv	9	26	on	on	IN
cord-301128-woe6knpv	9	27	possible	possible	JJ
cord-301128-woe6knpv	9	28	molecular	molecular	JJ
cord-301128-woe6knpv	9	29	actors	actor	NNS
cord-301128-woe6knpv	9	30	.	.	.
cord-301128-woe6knpv	10	1	Here	here	RB
cord-301128-woe6knpv	10	2	,	,	,
cord-301128-woe6knpv	10	3	we	-PRON-	PRP
cord-301128-woe6knpv	10	4	address	address	VBP
cord-301128-woe6knpv	10	5	the	the	DT
cord-301128-woe6knpv	10	6	question	question	NN
cord-301128-woe6knpv	10	7	of	of	IN
cord-301128-woe6knpv	10	8	topological	topological	JJ
cord-301128-woe6knpv	10	9	barriers	barrier	NNS
cord-301128-woe6knpv	10	10	using	use	VBG
cord-301128-woe6knpv	10	11	polymer	polymer	NN
cord-301128-woe6knpv	10	12	models	model	NNS
cord-301128-woe6knpv	10	13	of	of	IN
cord-301128-woe6knpv	10	14	supercoiled	supercoiled	JJ
cord-301128-woe6knpv	10	15	DNA	dna	NN
cord-301128-woe6knpv	10	16	chains	chain	NNS
cord-301128-woe6knpv	10	17	that	that	WDT
cord-301128-woe6knpv	10	18	are	be	VBP
cord-301128-woe6knpv	10	19	constrained	constrain	VBN
cord-301128-woe6knpv	10	20	such	such	JJ
cord-301128-woe6knpv	10	21	as	as	IN
cord-301128-woe6knpv	10	22	to	to	TO
cord-301128-woe6knpv	10	23	mimic	mimic	VB
cord-301128-woe6knpv	10	24	the	the	DT
cord-301128-woe6knpv	10	25	action	action	NN
cord-301128-woe6knpv	10	26	of	of	IN
cord-301128-woe6knpv	10	27	predicted	predict	VBN
cord-301128-woe6knpv	10	28	molecular	molecular	JJ
cord-301128-woe6knpv	10	29	actors	actor	NNS
cord-301128-woe6knpv	10	30	.	.	.
cord-301128-woe6knpv	11	1	More	more	RBR
cord-301128-woe6knpv	11	2	specifically	specifically	RB
cord-301128-woe6knpv	11	3	,	,	,
cord-301128-woe6knpv	11	4	we	-PRON-	PRP
cord-301128-woe6knpv	11	5	determine	determine	VBP
cord-301128-woe6knpv	11	6	under	under	IN
cord-301128-woe6knpv	11	7	which	which	WDT
cord-301128-woe6knpv	11	8	conditions	condition	NNS
cord-301128-woe6knpv	11	9	DNA	dna	NN
cord-301128-woe6knpv	11	10	-	-	HYPH
cord-301128-woe6knpv	11	11	bridging	bridge	VBG
cord-301128-woe6knpv	11	12	proteins	protein	NNS
cord-301128-woe6knpv	11	13	may	may	MD
cord-301128-woe6knpv	11	14	act	act	VB
cord-301128-woe6knpv	11	15	as	as	IN
cord-301128-woe6knpv	11	16	topological	topological	JJ
cord-301128-woe6knpv	11	17	barriers	barrier	NNS
cord-301128-woe6knpv	11	18	.	.	.
cord-301128-woe6knpv	12	1	To	to	IN
cord-301128-woe6knpv	12	2	this	this	DT
cord-301128-woe6knpv	12	3	end	end	NN
cord-301128-woe6knpv	12	4	,	,	,
cord-301128-woe6knpv	12	5	we	-PRON-	PRP
cord-301128-woe6knpv	12	6	developed	develop	VBD
cord-301128-woe6knpv	12	7	a	a	DT
cord-301128-woe6knpv	12	8	coarse	coarse	RB
cord-301128-woe6knpv	12	9	-	-	HYPH
cord-301128-woe6knpv	12	10	grained	grained	JJ
cord-301128-woe6knpv	12	11	bead	bead	NN
cord-301128-woe6knpv	12	12	-	-	HYPH
cord-301128-woe6knpv	12	13	and	and	CC
cord-301128-woe6knpv	12	14	-	-	HYPH
cord-301128-woe6knpv	12	15	spring	spring	NN
cord-301128-woe6knpv	12	16	model	model	NN
cord-301128-woe6knpv	12	17	and	and	CC
cord-301128-woe6knpv	12	18	investigated	investigate	VBD
cord-301128-woe6knpv	12	19	its	-PRON-	PRP$
cord-301128-woe6knpv	12	20	properties	property	NNS
cord-301128-woe6knpv	12	21	through	through	IN
cord-301128-woe6knpv	12	22	Brownian	Brownian	NNP
cord-301128-woe6knpv	12	23	dynamics	dynamic	NNS
cord-301128-woe6knpv	12	24	simulations	simulation	NNS
cord-301128-woe6knpv	12	25	.	.	.
cord-301128-woe6knpv	13	1	As	as	IN
cord-301128-woe6knpv	13	2	a	a	DT
cord-301128-woe6knpv	13	3	result	result	NN
cord-301128-woe6knpv	13	4	,	,	,
cord-301128-woe6knpv	13	5	we	-PRON-	PRP
cord-301128-woe6knpv	13	6	find	find	VBP
cord-301128-woe6knpv	13	7	that	that	IN
cord-301128-woe6knpv	13	8	DNA	dna	NN
cord-301128-woe6knpv	13	9	-	-	HYPH
cord-301128-woe6knpv	13	10	bridging	bridge	VBG
cord-301128-woe6knpv	13	11	proteins	protein	NNS
cord-301128-woe6knpv	13	12	must	must	MD
cord-301128-woe6knpv	13	13	exert	exert	VB
cord-301128-woe6knpv	13	14	rather	rather	RB
cord-301128-woe6knpv	13	15	strong	strong	JJ
cord-301128-woe6knpv	13	16	constraints	constraint	NNS
cord-301128-woe6knpv	13	17	on	on	IN
cord-301128-woe6knpv	13	18	their	-PRON-	PRP$
cord-301128-woe6knpv	13	19	binding	bind	VBG
cord-301128-woe6knpv	13	20	sites	site	NNS
cord-301128-woe6knpv	13	21	:	:	:
cord-301128-woe6knpv	13	22	they	-PRON-	PRP
cord-301128-woe6knpv	13	23	must	must	MD
cord-301128-woe6knpv	13	24	block	block	VB
cord-301128-woe6knpv	13	25	the	the	DT
cord-301128-woe6knpv	13	26	diffusion	diffusion	NN
cord-301128-woe6knpv	13	27	of	of	IN
cord-301128-woe6knpv	13	28	the	the	DT
cord-301128-woe6knpv	13	29	excess	excess	NN
cord-301128-woe6knpv	13	30	of	of	IN
cord-301128-woe6knpv	13	31	twist	twist	NN
cord-301128-woe6knpv	13	32	through	through	IN
cord-301128-woe6knpv	13	33	the	the	DT
cord-301128-woe6knpv	13	34	two	two	CD
cord-301128-woe6knpv	13	35	binding	bind	VBG
cord-301128-woe6knpv	13	36	sites	site	NNS
cord-301128-woe6knpv	13	37	on	on	IN
cord-301128-woe6knpv	13	38	the	the	DT
cord-301128-woe6knpv	13	39	DNA	dna	NN
cord-301128-woe6knpv	13	40	molecule	molecule	NN
cord-301128-woe6knpv	13	41	and	and	CC
cord-301128-woe6knpv	13	42	,	,	,
cord-301128-woe6knpv	13	43	simultaneously	simultaneously	RB
cord-301128-woe6knpv	13	44	,	,	,
cord-301128-woe6knpv	13	45	prevent	prevent	VB
cord-301128-woe6knpv	13	46	the	the	DT
cord-301128-woe6knpv	13	47	rotation	rotation	NN
cord-301128-woe6knpv	13	48	of	of	IN
cord-301128-woe6knpv	13	49	one	one	CD
cord-301128-woe6knpv	13	50	DNA	dna	NN
cord-301128-woe6knpv	13	51	segment	segment	NN
cord-301128-woe6knpv	13	52	relative	relative	JJ
cord-301128-woe6knpv	13	53	to	to	IN
cord-301128-woe6knpv	13	54	the	the	DT
cord-301128-woe6knpv	13	55	other	other	JJ
cord-301128-woe6knpv	13	56	one	one	NN
cord-301128-woe6knpv	13	57	.	.	.
cord-301128-woe6knpv	14	1	Importantly	importantly	RB
cord-301128-woe6knpv	14	2	,	,	,
cord-301128-woe6knpv	14	3	not	not	RB
cord-301128-woe6knpv	14	4	all	all	DT
cord-301128-woe6knpv	14	5	DNA	dna	NN
cord-301128-woe6knpv	14	6	-	-	HYPH
cord-301128-woe6knpv	14	7	bridging	bridge	VBG
cord-301128-woe6knpv	14	8	proteins	protein	NNS
cord-301128-woe6knpv	14	9	satisfy	satisfy	VBP
cord-301128-woe6knpv	14	10	this	this	DT
cord-301128-woe6knpv	14	11	second	second	JJ
cord-301128-woe6knpv	14	12	condition	condition	NN
cord-301128-woe6knpv	14	13	.	.	.
cord-301128-woe6knpv	15	1	For	for	IN
cord-301128-woe6knpv	15	2	example	example	NN
cord-301128-woe6knpv	15	3	,	,	,
cord-301128-woe6knpv	15	4	single	single	JJ
cord-301128-woe6knpv	15	5	bridges	bridge	NNS
cord-301128-woe6knpv	15	6	formed	form	VBN
cord-301128-woe6knpv	15	7	by	by	IN
cord-301128-woe6knpv	15	8	proteins	protein	NNS
cord-301128-woe6knpv	15	9	that	that	WDT
cord-301128-woe6knpv	15	10	bind	bind	VBP
cord-301128-woe6knpv	15	11	DNA	DNA	NNP
cord-301128-woe6knpv	15	12	non	non	NN
cord-301128-woe6knpv	15	13	-	-	JJ
cord-301128-woe6knpv	15	14	specifically	specifically	RB
cord-301128-woe6knpv	15	15	,	,	,
cord-301128-woe6knpv	15	16	like	like	IN
cord-301128-woe6knpv	15	17	H	H	NNP
cord-301128-woe6knpv	15	18	-	-	HYPH
cord-301128-woe6knpv	15	19	NS	NS	NNP
cord-301128-woe6knpv	15	20	dimers	dimer	NNS
cord-301128-woe6knpv	15	21	,	,	,
cord-301128-woe6knpv	15	22	are	be	VBP
cord-301128-woe6knpv	15	23	expected	expect	VBN
cord-301128-woe6knpv	15	24	to	to	TO
cord-301128-woe6knpv	15	25	fail	fail	VB
cord-301128-woe6knpv	15	26	with	with	IN
cord-301128-woe6knpv	15	27	this	this	DT
cord-301128-woe6knpv	15	28	respect	respect	NN
cord-301128-woe6knpv	15	29	.	.	.
cord-301128-woe6knpv	16	1	Our	-PRON-	PRP$
cord-301128-woe6knpv	16	2	findings	finding	NNS
cord-301128-woe6knpv	16	3	might	may	MD
cord-301128-woe6knpv	16	4	also	also	RB
cord-301128-woe6knpv	16	5	explain	explain	VB
cord-301128-woe6knpv	16	6	,	,	,
cord-301128-woe6knpv	16	7	in	in	IN
cord-301128-woe6knpv	16	8	the	the	DT
cord-301128-woe6knpv	16	9	case	case	NN
cord-301128-woe6knpv	16	10	of	of	IN
cord-301128-woe6knpv	16	11	specific	specific	JJ
cord-301128-woe6knpv	16	12	DNA	dna	NN
cord-301128-woe6knpv	16	13	-	-	HYPH
cord-301128-woe6knpv	16	14	bridging	bridge	VBG
cord-301128-woe6knpv	16	15	proteins	protein	NNS
cord-301128-woe6knpv	16	16	like	like	IN
cord-301128-woe6knpv	16	17	LacI	LacI	NNP
cord-301128-woe6knpv	16	18	,	,	,
cord-301128-woe6knpv	16	19	why	why	WRB
cord-301128-woe6knpv	16	20	multiple	multiple	JJ
cord-301128-woe6knpv	16	21	bridges	bridge	NNS
cord-301128-woe6knpv	16	22	are	be	VBP
cord-301128-woe6knpv	16	23	required	require	VBN
cord-301128-woe6knpv	16	24	to	to	TO
cord-301128-woe6knpv	16	25	create	create	VB
cord-301128-woe6knpv	16	26	stable	stable	JJ
cord-301128-woe6knpv	16	27	independent	independent	JJ
cord-301128-woe6knpv	16	28	topological	topological	JJ
cord-301128-woe6knpv	16	29	domains	domain	NNS
cord-301128-woe6knpv	16	30	.	.	.
cord-301128-woe6knpv	17	1	Strikingly	strikingly	RB
cord-301128-woe6knpv	17	2	,	,	,
cord-301128-woe6knpv	17	3	when	when	WRB
cord-301128-woe6knpv	17	4	the	the	DT
cord-301128-woe6knpv	17	5	relative	relative	JJ
cord-301128-woe6knpv	17	6	rotation	rotation	NN
cord-301128-woe6knpv	17	7	of	of	IN
cord-301128-woe6knpv	17	8	the	the	DT
cord-301128-woe6knpv	17	9	DNA	dna	NN
cord-301128-woe6knpv	17	10	segments	segment	NNS
cord-301128-woe6knpv	17	11	is	be	VBZ
cord-301128-woe6knpv	17	12	not	not	RB
cord-301128-woe6knpv	17	13	prevented	prevent	VBN
cord-301128-woe6knpv	17	14	,	,	,
cord-301128-woe6knpv	17	15	relaxation	relaxation	NN
cord-301128-woe6knpv	17	16	results	result	NNS
cord-301128-woe6knpv	17	17	in	in	IN
cord-301128-woe6knpv	17	18	complex	complex	JJ
cord-301128-woe6knpv	17	19	intrication	intrication	NN
cord-301128-woe6knpv	17	20	of	of	IN
cord-301128-woe6knpv	17	21	the	the	DT
cord-301128-woe6knpv	17	22	two	two	CD
cord-301128-woe6knpv	17	23	domains	domain	NNS
cord-301128-woe6knpv	17	24	.	.	.
cord-301128-woe6knpv	18	1	Moreover	moreover	RB
cord-301128-woe6knpv	18	2	,	,	,
cord-301128-woe6knpv	18	3	while	while	IN
cord-301128-woe6knpv	18	4	the	the	DT
cord-301128-woe6knpv	18	5	value	value	NN
cord-301128-woe6knpv	18	6	of	of	IN
cord-301128-woe6knpv	18	7	the	the	DT
cord-301128-woe6knpv	18	8	torsional	torsional	JJ
cord-301128-woe6knpv	18	9	stress	stress	NN
cord-301128-woe6knpv	18	10	in	in	IN
cord-301128-woe6knpv	18	11	each	each	DT
cord-301128-woe6knpv	18	12	domain	domain	NN
cord-301128-woe6knpv	18	13	may	may	MD
cord-301128-woe6knpv	18	14	vary	vary	VB
cord-301128-woe6knpv	18	15	,	,	,
cord-301128-woe6knpv	18	16	their	-PRON-	PRP$
cord-301128-woe6knpv	18	17	differential	differential	NN
cord-301128-woe6knpv	18	18	is	be	VBZ
cord-301128-woe6knpv	18	19	preserved	preserve	VBN
cord-301128-woe6knpv	18	20	.	.	.
cord-301128-woe6knpv	19	1	Our	-PRON-	PRP$
cord-301128-woe6knpv	19	2	work	work	NN
cord-301128-woe6knpv	19	3	also	also	RB
cord-301128-woe6knpv	19	4	predicts	predict	VBZ
cord-301128-woe6knpv	19	5	that	that	IN
cord-301128-woe6knpv	19	6	nucleoid	nucleoid	NNP
cord-301128-woe6knpv	19	7	associated	associate	VBD
cord-301128-woe6knpv	19	8	proteins	protein	NNS
cord-301128-woe6knpv	19	9	known	know	VBN
cord-301128-woe6knpv	19	10	to	to	TO
cord-301128-woe6knpv	19	11	wrap	wrap	VB
cord-301128-woe6knpv	19	12	DNA	DNA	NNP
cord-301128-woe6knpv	19	13	must	must	MD
cord-301128-woe6knpv	19	14	form	form	VB
cord-301128-woe6knpv	19	15	higher	high	JJR
cord-301128-woe6knpv	19	16	protein	protein	NN
cord-301128-woe6knpv	19	17	-	-	HYPH
cord-301128-woe6knpv	19	18	DNA	dna	NN
cord-301128-woe6knpv	19	19	complexes	complex	NNS
cord-301128-woe6knpv	19	20	to	to	TO
cord-301128-woe6knpv	19	21	efficiently	efficiently	RB
cord-301128-woe6knpv	19	22	work	work	VB
cord-301128-woe6knpv	19	23	as	as	IN
cord-301128-woe6knpv	19	24	topological	topological	JJ
cord-301128-woe6knpv	19	25	barriers	barrier	NNS
cord-301128-woe6knpv	19	26	.	.	.
cord-301128-woe6knpv	20	1	The	the	DT
cord-301128-woe6knpv	20	2	genetic	genetic	JJ
cord-301128-woe6knpv	20	3	information	information	NN
cord-301128-woe6knpv	20	4	of	of	IN
cord-301128-woe6knpv	20	5	most	most	JJS
cord-301128-woe6knpv	20	6	bacteria	bacteria	NNS
cord-301128-woe6knpv	20	7	is	be	VBZ
cord-301128-woe6knpv	20	8	encoded	encode	VBN
cord-301128-woe6knpv	20	9	in	in	IN
cord-301128-woe6knpv	20	10	a	a	DT
cord-301128-woe6knpv	20	11	circular	circular	JJ
cord-301128-woe6knpv	20	12	DNA	dna	NN
cord-301128-woe6knpv	20	13	molecule	molecule	NN
cord-301128-woe6knpv	20	14	comprising	comprise	VBG
cord-301128-woe6knpv	20	15	up	up	RP
cord-301128-woe6knpv	20	16	to	to	IN
cord-301128-woe6knpv	20	17	several	several	JJ
cord-301128-woe6knpv	20	18	millions	million	NNS
cord-301128-woe6knpv	20	19	of	of	IN
cord-301128-woe6knpv	20	20	base	base	NN
cord-301128-woe6knpv	20	21	pairs	pair	NNS
cord-301128-woe6knpv	20	22	(	(	-LRB-
cord-301128-woe6knpv	20	23	bp	bp	NNP
cord-301128-woe6knpv	20	24	)	)	-RRB-
cord-301128-woe6knpv	20	25	.	.	.
cord-301128-woe6knpv	21	1	Such	such	JJ
cord-301128-woe6knpv	21	2	closed	closed	JJ
cord-301128-woe6knpv	21	3	molecules	molecule	NNS
cord-301128-woe6knpv	21	4	are	be	VBP
cord-301128-woe6knpv	21	5	topologically	topologically	RB
cord-301128-woe6knpv	21	6	constrained	constrain	VBN
cord-301128-woe6knpv	21	7	,	,	,
cord-301128-woe6knpv	21	8	because	because	IN
cord-301128-woe6knpv	21	9	they	-PRON-	PRP
cord-301128-woe6knpv	21	10	lack	lack	VBP
cord-301128-woe6knpv	21	11	free	free	JJ
cord-301128-woe6knpv	21	12	ends	end	NNS
cord-301128-woe6knpv	21	13	capable	capable	JJ
cord-301128-woe6knpv	21	14	of	of	IN
cord-301128-woe6knpv	21	15	rotating	rotate	VBG
cord-301128-woe6knpv	21	16	and	and	CC
cord-301128-woe6knpv	21	17	releasing	release	VBG
cord-301128-woe6knpv	21	18	the	the	DT
cord-301128-woe6knpv	21	19	torsional	torsional	JJ
cord-301128-woe6knpv	21	20	stress	stress	NN
cord-301128-woe6knpv	21	21	(	(	-LRB-
cord-301128-woe6knpv	21	22	1	1	CD
cord-301128-woe6knpv	21	23	)	)	-RRB-
cord-301128-woe6knpv	21	24	.	.	.
cord-301128-woe6knpv	22	1	In	in	IN
cord-301128-woe6knpv	22	2	vivo	vivo	NN
cord-301128-woe6knpv	22	3	alterations	alteration	NNS
cord-301128-woe6knpv	22	4	of	of	IN
cord-301128-woe6knpv	22	5	the	the	DT
cord-301128-woe6knpv	22	6	torsional	torsional	JJ
cord-301128-woe6knpv	22	7	state	state	NN
cord-301128-woe6knpv	22	8	of	of	IN
cord-301128-woe6knpv	22	9	circular	circular	JJ
cord-301128-woe6knpv	22	10	DNA	dna	NN
cord-301128-woe6knpv	22	11	is	be	VBZ
cord-301128-woe6knpv	22	12	mediated	mediate	VBN
cord-301128-woe6knpv	22	13	by	by	IN
cord-301128-woe6knpv	22	14	the	the	DT
cord-301128-woe6knpv	22	15	recruitment	recruitment	NN
cord-301128-woe6knpv	22	16	of	of	IN
cord-301128-woe6knpv	22	17	enzymes	enzyme	NNS
cord-301128-woe6knpv	22	18	called	call	VBN
cord-301128-woe6knpv	22	19	topoisomerases	topoisomerase	NNS
cord-301128-woe6knpv	22	20	,	,	,
cord-301128-woe6knpv	22	21	which	which	WDT
cord-301128-woe6knpv	22	22	can	can	MD
cord-301128-woe6knpv	22	23	either	either	CC
cord-301128-woe6knpv	22	24	increase	increase	VB
cord-301128-woe6knpv	22	25	or	or	CC
cord-301128-woe6knpv	22	26	decrease	decrease	VB
cord-301128-woe6knpv	22	27	the	the	DT
cord-301128-woe6knpv	22	28	twist	twist	NN
cord-301128-woe6knpv	22	29	of	of	IN
cord-301128-woe6knpv	22	30	the	the	DT
cord-301128-woe6knpv	22	31	double	double	JJ
cord-301128-woe6knpv	22	32	helix	helix	NN
cord-301128-woe6knpv	22	33	by	by	IN
cord-301128-woe6knpv	22	34	opening	open	VBG
cord-301128-woe6knpv	22	35	transiently	transiently	RB
cord-301128-woe6knpv	22	36	one	one	CD
cord-301128-woe6knpv	22	37	or	or	CC
cord-301128-woe6knpv	22	38	two	two	CD
cord-301128-woe6knpv	22	39	strands	strand	NNS
cord-301128-woe6knpv	22	40	(	(	-LRB-
cord-301128-woe6knpv	22	41	1	1	CD
cord-301128-woe6knpv	22	42	)	)	-RRB-
cord-301128-woe6knpv	22	43	.	.	.
cord-301128-woe6knpv	23	1	The	the	DT
cord-301128-woe6knpv	23	2	net	net	JJ
cord-301128-woe6knpv	23	3	result	result	NN
cord-301128-woe6knpv	23	4	of	of	IN
cord-301128-woe6knpv	23	5	the	the	DT
cord-301128-woe6knpv	23	6	action	action	NN
cord-301128-woe6knpv	23	7	of	of	IN
cord-301128-woe6knpv	23	8	all	all	DT
cord-301128-woe6knpv	23	9	types	type	NNS
cord-301128-woe6knpv	23	10	of	of	IN
cord-301128-woe6knpv	23	11	topoisomerases	topoisomerase	NNS
cord-301128-woe6knpv	23	12	is	be	VBZ
cord-301128-woe6knpv	23	13	that	that	IN
cord-301128-woe6knpv	23	14	the	the	DT
cord-301128-woe6knpv	23	15	genomic	genomic	JJ
cord-301128-woe6knpv	23	16	DNA	dna	NN
cord-301128-woe6knpv	23	17	of	of	IN
cord-301128-woe6knpv	23	18	most	most	JJS
cord-301128-woe6knpv	23	19	bacteria	bacteria	NNS
cord-301128-woe6knpv	23	20	is	be	VBZ
cord-301128-woe6knpv	23	21	significantly	significantly	RB
cord-301128-woe6knpv	23	22	undertwisted	undertwiste	VBN
cord-301128-woe6knpv	23	23	(	(	-LRB-
cord-301128-woe6knpv	23	24	negatively	negatively	RB
cord-301128-woe6knpv	23	25	supercoiled	supercoile	VBN
cord-301128-woe6knpv	23	26	)	)	-RRB-
cord-301128-woe6knpv	23	27	and	and	CC
cord-301128-woe6knpv	23	28	winds	wind	NNS
cord-301128-woe6knpv	23	29	about	about	IN
cord-301128-woe6knpv	23	30	itself	-PRON-	PRP
cord-301128-woe6knpv	23	31	to	to	TO
cord-301128-woe6knpv	23	32	transfer	transfer	VB
cord-301128-woe6knpv	23	33	part	part	NN
cord-301128-woe6knpv	23	34	of	of	IN
cord-301128-woe6knpv	23	35	the	the	DT
cord-301128-woe6knpv	23	36	torsional	torsional	JJ
cord-301128-woe6knpv	23	37	stress	stress	NN
cord-301128-woe6knpv	23	38	to	to	IN
cord-301128-woe6knpv	23	39	the	the	DT
cord-301128-woe6knpv	23	40	bending	bend	VBG
cord-301128-woe6knpv	23	41	degrees	degree	NNS
cord-301128-woe6knpv	23	42	of	of	IN
cord-301128-woe6knpv	23	43	freedom	freedom	NN
cord-301128-woe6knpv	23	44	,	,	,
cord-301128-woe6knpv	23	45	thereby	thereby	RB
cord-301128-woe6knpv	23	46	forming	form	VBG
cord-301128-woe6knpv	23	47	plectonemes	plectonemes	NNP
cord-301128-woe6knpv	23	48	(	(	-LRB-
cord-301128-woe6knpv	23	49	1	1	CD
cord-301128-woe6knpv	23	50	)	)	-RRB-
cord-301128-woe6knpv	23	51	.	.	.
cord-301128-woe6knpv	24	1	If	if	IN
cord-301128-woe6knpv	24	2	the	the	DT
cord-301128-woe6knpv	24	3	DNA	dna	NN
cord-301128-woe6knpv	24	4	were	be	VBD
cord-301128-woe6knpv	24	5	not	not	RB
cord-301128-woe6knpv	24	6	subject	subject	JJ
cord-301128-woe6knpv	24	7	to	to	IN
cord-301128-woe6knpv	24	8	any	any	DT
cord-301128-woe6knpv	24	9	additional	additional	JJ
cord-301128-woe6knpv	24	10	constraint	constraint	NN
cord-301128-woe6knpv	24	11	beyond	beyond	IN
cord-301128-woe6knpv	24	12	closure	closure	NN
cord-301128-woe6knpv	24	13	,	,	,
cord-301128-woe6knpv	24	14	then	then	RB
cord-301128-woe6knpv	24	15	one	one	CD
cord-301128-woe6knpv	24	16	single	single	JJ
cord-301128-woe6knpv	24	17	nick	nick	NNP
cord-301128-woe6knpv	24	18	of	of	IN
cord-301128-woe6knpv	24	19	one	one	CD
cord-301128-woe6knpv	24	20	strand	strand	NN
cord-301128-woe6knpv	24	21	or	or	CC
cord-301128-woe6knpv	24	22	one	one	CD
cord-301128-woe6knpv	24	23	single	single	JJ
cord-301128-woe6knpv	24	24	break	break	NN
cord-301128-woe6knpv	24	25	of	of	IN
cord-301128-woe6knpv	24	26	the	the	DT
cord-301128-woe6knpv	24	27	two	two	CD
cord-301128-woe6knpv	24	28	strands	strand	NNS
cord-301128-woe6knpv	24	29	would	would	MD
cord-301128-woe6knpv	24	30	suffice	suffice	VB
cord-301128-woe6knpv	24	31	to	to	TO
cord-301128-woe6knpv	24	32	release	release	VB
cord-301128-woe6knpv	24	33	the	the	DT
cord-301128-woe6knpv	24	34	torsional	torsional	JJ
cord-301128-woe6knpv	24	35	stress	stress	NN
cord-301128-woe6knpv	24	36	of	of	IN
cord-301128-woe6knpv	24	37	the	the	DT
cord-301128-woe6knpv	24	38	full	full	JJ
cord-301128-woe6knpv	24	39	molecule	molecule	NN
cord-301128-woe6knpv	24	40	.	.	.
cord-301128-woe6knpv	25	1	It	-PRON-	PRP
cord-301128-woe6knpv	25	2	has	have	VBZ
cord-301128-woe6knpv	25	3	however	however	RB
cord-301128-woe6knpv	25	4	long	long	RB
cord-301128-woe6knpv	25	5	be	be	VB
cord-301128-woe6knpv	25	6	known	know	VBN
cord-301128-woe6knpv	25	7	that	that	IN
cord-301128-woe6knpv	25	8	at	at	RB
cord-301128-woe6knpv	25	9	least	least	JJS
cord-301128-woe6knpv	25	10	several	several	JJ
cord-301128-woe6knpv	25	11	tens	ten	NNS
cord-301128-woe6knpv	25	12	of	of	IN
cord-301128-woe6knpv	25	13	nicks	nick	NNS
cord-301128-woe6knpv	25	14	are	be	VBP
cord-301128-woe6knpv	25	15	required	require	VBN
cord-301128-woe6knpv	25	16	to	to	TO
cord-301128-woe6knpv	25	17	achieve	achieve	VB
cord-301128-woe6knpv	25	18	this	this	DT
cord-301128-woe6knpv	25	19	goal	goal	NN
cord-301128-woe6knpv	25	20	in	in	IN
cord-301128-woe6knpv	25	21	Escherichia	Escherichia	NNP
cord-301128-woe6knpv	25	22	coli	coli	NNS
cord-301128-woe6knpv	25	23	(	(	-LRB-
cord-301128-woe6knpv	25	24	2	2	CD
cord-301128-woe6knpv	25	25	,	,	,
cord-301128-woe6knpv	25	26	3	3	CD
cord-301128-woe6knpv	25	27	)	)	-RRB-
cord-301128-woe6knpv	25	28	.	.	.
cord-301128-woe6knpv	26	1	This	this	DT
cord-301128-woe6knpv	26	2	indicates	indicate	VBZ
cord-301128-woe6knpv	26	3	that	that	IN
cord-301128-woe6knpv	26	4	there	there	EX
cord-301128-woe6knpv	26	5	exist	exist	VBP
cord-301128-woe6knpv	26	6	barriers	barrier	NNS
cord-301128-woe6knpv	26	7	which	which	WDT
cord-301128-woe6knpv	26	8	block	block	VBP
cord-301128-woe6knpv	26	9	the	the	DT
cord-301128-woe6knpv	26	10	diffusion	diffusion	NN
cord-301128-woe6knpv	26	11	of	of	IN
cord-301128-woe6knpv	26	12	the	the	DT
cord-301128-woe6knpv	26	13	torsional	torsional	JJ
cord-301128-woe6knpv	26	14	stress	stress	NN
cord-301128-woe6knpv	26	15	along	along	IN
cord-301128-woe6knpv	26	16	the	the	DT
cord-301128-woe6knpv	26	17	DNA	dna	NN
cord-301128-woe6knpv	26	18	molecule	molecule	NN
cord-301128-woe6knpv	26	19	and	and	CC
cord-301128-woe6knpv	26	20	organize	organize	VB
cord-301128-woe6knpv	26	21	the	the	DT
cord-301128-woe6knpv	26	22	chromosome	chromosome	NN
cord-301128-woe6knpv	26	23	of	of	IN
cord-301128-woe6knpv	26	24	E.	E.	NNP
cord-301128-woe6knpv	26	25	coli	coli	NNS
cord-301128-woe6knpv	26	26	into	into	IN
cord-301128-woe6knpv	26	27	many	many	JJ
cord-301128-woe6knpv	26	28	independent	independent	JJ
cord-301128-woe6knpv	26	29	topological	topological	JJ
cord-301128-woe6knpv	26	30	domains	domain	NNS
cord-301128-woe6knpv	26	31	,	,	,
cord-301128-woe6knpv	26	32	whose	whose	WP$
cord-301128-woe6knpv	26	33	torsional	torsional	JJ
cord-301128-woe6knpv	26	34	state	state	NN
cord-301128-woe6knpv	26	35	is	be	VBZ
cord-301128-woe6knpv	26	36	not	not	RB
cord-301128-woe6knpv	26	37	affected	affect	VBN
cord-301128-woe6knpv	26	38	by	by	IN
cord-301128-woe6knpv	26	39	the	the	DT
cord-301128-woe6knpv	26	40	relaxation	relaxation	NN
cord-301128-woe6knpv	26	41	of	of	IN
cord-301128-woe6knpv	26	42	other	other	JJ
cord-301128-woe6knpv	26	43	domains	domain	NNS
cord-301128-woe6knpv	26	44	.	.	.
cord-301128-woe6knpv	27	1	It	-PRON-	PRP
cord-301128-woe6knpv	27	2	is	be	VBZ
cord-301128-woe6knpv	27	3	currently	currently	RB
cord-301128-woe6knpv	27	4	estimated	estimate	VBN
cord-301128-woe6knpv	27	5	that	that	IN
cord-301128-woe6knpv	27	6	the	the	DT
cord-301128-woe6knpv	27	7	genomic	genomic	JJ
cord-301128-woe6knpv	27	8	DNA	dna	NN
cord-301128-woe6knpv	27	9	of	of	IN
cord-301128-woe6knpv	27	10	bacteria	bacteria	NNS
cord-301128-woe6knpv	27	11	like	like	IN
cord-301128-woe6knpv	27	12	E.	E.	NNP
cord-301128-woe6knpv	27	13	coli	coli	NNS
cord-301128-woe6knpv	27	14	is	be	VBZ
cord-301128-woe6knpv	27	15	composed	compose	VBN
cord-301128-woe6knpv	27	16	of	of	IN
cord-301128-woe6knpv	27	17	several	several	JJ
cord-301128-woe6knpv	27	18	hundreds	hundred	NNS
cord-301128-woe6knpv	27	19	of	of	IN
cord-301128-woe6knpv	27	20	different	different	JJ
cord-301128-woe6knpv	27	21	topological	topological	JJ
cord-301128-woe6knpv	27	22	domains	domain	NNS
cord-301128-woe6knpv	27	23	with	with	IN
cord-301128-woe6knpv	27	24	variable	variable	JJ
cord-301128-woe6knpv	27	25	size	size	NN
cord-301128-woe6knpv	27	26	(	(	-LRB-
cord-301128-woe6knpv	27	27	average	average	JJ
cord-301128-woe6knpv	27	28	size	size	NN
cord-301128-woe6knpv	27	29	≈10	≈10	NNP
cord-301128-woe6knpv	27	30	kbp	kbp	NNP
cord-301128-woe6knpv	27	31	)	)	-RRB-
cord-301128-woe6knpv	27	32	and	and	CC
cord-301128-woe6knpv	27	33	position	position	NN
cord-301128-woe6knpv	27	34	(	(	-LRB-
cord-301128-woe6knpv	27	35	4	4	CD
cord-301128-woe6knpv	27	36	)	)	-RRB-
cord-301128-woe6knpv	27	37	.	.	.
cord-301128-woe6knpv	28	1	More	more	RBR
cord-301128-woe6knpv	28	2	generally	generally	RB
cord-301128-woe6knpv	28	3	,	,	,
cord-301128-woe6knpv	28	4	the	the	DT
cord-301128-woe6knpv	28	5	partitioning	partitioning	NN
cord-301128-woe6knpv	28	6	of	of	IN
cord-301128-woe6knpv	28	7	the	the	DT
cord-301128-woe6knpv	28	8	bacterial	bacterial	JJ
cord-301128-woe6knpv	28	9	chromosome	chromosome	NN
cord-301128-woe6knpv	28	10	into	into	IN
cord-301128-woe6knpv	28	11	≈10	≈10	NNP
cord-301128-woe6knpv	28	12	kbp	kbp	NNP
cord-301128-woe6knpv	28	13	independent	independent	JJ
cord-301128-woe6knpv	28	14	topological	topological	JJ
cord-301128-woe6knpv	28	15	domains	domain	NNS
cord-301128-woe6knpv	28	16	is	be	VBZ
cord-301128-woe6knpv	28	17	believed	believe	VBN
cord-301128-woe6knpv	28	18	to	to	TO
cord-301128-woe6knpv	28	19	hold	hold	VB
cord-301128-woe6knpv	28	20	in	in	RP
cord-301128-woe6knpv	28	21	most	most	JJS
cord-301128-woe6knpv	28	22	bacteria	bacteria	NNS
cord-301128-woe6knpv	28	23	(	(	-LRB-
cord-301128-woe6knpv	28	24	5	5	CD
cord-301128-woe6knpv	28	25	)	)	-RRB-
cord-301128-woe6knpv	28	26	and	and	CC
cord-301128-woe6knpv	28	27	to	to	TO
cord-301128-woe6knpv	28	28	be	be	VB
cord-301128-woe6knpv	28	29	related	relate	VBN
cord-301128-woe6knpv	28	30	,	,	,
cord-301128-woe6knpv	28	31	in	in	IN
cord-301128-woe6knpv	28	32	part	part	NN
cord-301128-woe6knpv	28	33	,	,	,
cord-301128-woe6knpv	28	34	to	to	IN
cord-301128-woe6knpv	28	35	the	the	DT
cord-301128-woe6knpv	28	36	insulation	insulation	NN
cord-301128-woe6knpv	28	37	of	of	IN
cord-301128-woe6knpv	28	38	fundamental	fundamental	JJ
cord-301128-woe6knpv	28	39	co	co	JJ
cord-301128-woe6knpv	28	40	-	-	JJ
cord-301128-woe6knpv	28	41	expression	expression	JJ
cord-301128-woe6knpv	28	42	units	unit	NNS
cord-301128-woe6knpv	28	43	that	that	WDT
cord-301128-woe6knpv	28	44	are	be	VBP
cord-301128-woe6knpv	28	45	neighbors	neighbor	NNS
cord-301128-woe6knpv	28	46	along	along	IN
cord-301128-woe6knpv	28	47	the	the	DT
cord-301128-woe6knpv	28	48	genome	genome	NN
cord-301128-woe6knpv	28	49	(	(	-LRB-
cord-301128-woe6knpv	28	50	6	6	CD
cord-301128-woe6knpv	28	51	)	)	-RRB-
cord-301128-woe6knpv	28	52	.	.	.
cord-301128-woe6knpv	29	1	The	the	DT
cord-301128-woe6knpv	29	2	work	work	NN
cord-301128-woe6knpv	29	3	reported	report	VBD
cord-301128-woe6knpv	29	4	here	here	RB
cord-301128-woe6knpv	29	5	deals	deal	VBZ
cord-301128-woe6knpv	29	6	with	with	IN
cord-301128-woe6knpv	29	7	the	the	DT
cord-301128-woe6knpv	29	8	topological	topological	JJ
cord-301128-woe6knpv	29	9	barriers	barrier	NNS
cord-301128-woe6knpv	29	10	which	which	WDT
cord-301128-woe6knpv	29	11	make	make	VBP
cord-301128-woe6knpv	29	12	this	this	DT
cord-301128-woe6knpv	29	13	partitioning	partitioning	NN
cord-301128-woe6knpv	29	14	possible	possible	JJ
cord-301128-woe6knpv	29	15	,	,	,
cord-301128-woe6knpv	29	16	that	that	RB
cord-301128-woe6knpv	29	17	is	is	RB
cord-301128-woe6knpv	29	18	,	,	,
cord-301128-woe6knpv	29	19	the	the	DT
cord-301128-woe6knpv	29	20	barriers	barrier	NNS
cord-301128-woe6knpv	29	21	which	which	WDT
cord-301128-woe6knpv	29	22	block	block	VBP
cord-301128-woe6knpv	29	23	the	the	DT
cord-301128-woe6knpv	29	24	diffusion	diffusion	NN
cord-301128-woe6knpv	29	25	of	of	IN
cord-301128-woe6knpv	29	26	torsional	torsional	JJ
cord-301128-woe6knpv	29	27	stress	stress	NN
cord-301128-woe6knpv	29	28	along	along	IN
cord-301128-woe6knpv	29	29	the	the	DT
cord-301128-woe6knpv	29	30	DNA	dna	NN
cord-301128-woe6knpv	29	31	molecule	molecule	NN
cord-301128-woe6knpv	29	32	and	and	CC
cord-301128-woe6knpv	29	33	are	be	VBP
cord-301128-woe6knpv	29	34	responsible	responsible	JJ
cord-301128-woe6knpv	29	35	for	for	IN
cord-301128-woe6knpv	29	36	its	-PRON-	PRP$
cord-301128-woe6knpv	29	37	division	division	NN
cord-301128-woe6knpv	29	38	into	into	IN
cord-301128-woe6knpv	29	39	independent	independent	JJ
cord-301128-woe6knpv	29	40	topological	topological	JJ
cord-301128-woe6knpv	29	41	domains	domain	NNS
cord-301128-woe6knpv	29	42	.	.	.
cord-301128-woe6knpv	30	1	Although	although	IN
cord-301128-woe6knpv	30	2	this	this	DT
cord-301128-woe6knpv	30	3	question	question	NN
cord-301128-woe6knpv	30	4	has	have	VBZ
cord-301128-woe6knpv	30	5	now	now	RB
cord-301128-woe6knpv	30	6	been	be	VBN
cord-301128-woe6knpv	30	7	addressed	address	VBN
cord-301128-woe6knpv	30	8	for	for	IN
cord-301128-woe6knpv	30	9	nearly	nearly	RB
cord-301128-woe6knpv	30	10	two	two	CD
cord-301128-woe6knpv	30	11	decades	decade	NNS
cord-301128-woe6knpv	30	12	(	(	-LRB-
cord-301128-woe6knpv	30	13	7	7	CD
cord-301128-woe6knpv	30	14	)	)	-RRB-
cord-301128-woe6knpv	30	15	(	(	-LRB-
cord-301128-woe6knpv	30	16	8)	8)	NNP
cord-301128-woe6knpv	30	17	(	(	-LRB-
cord-301128-woe6knpv	30	18	9	9	CD
cord-301128-woe6knpv	30	19	)	)	-RRB-
cord-301128-woe6knpv	30	20	,	,	,
cord-301128-woe6knpv	30	21	the	the	DT
cord-301128-woe6knpv	30	22	mechanisms	mechanism	NNS
cord-301128-woe6knpv	30	23	underlying	underlie	VBG
cord-301128-woe6knpv	30	24	the	the	DT
cord-301128-woe6knpv	30	25	formation	formation	NN
cord-301128-woe6knpv	30	26	of	of	IN
cord-301128-woe6knpv	30	27	topological	topological	JJ
cord-301128-woe6knpv	30	28	barriers	barrier	NNS
cord-301128-woe6knpv	30	29	remain	remain	VBP
cord-301128-woe6knpv	30	30	mostly	mostly	RB
cord-301128-woe6knpv	30	31	elusive	elusive	JJ
cord-301128-woe6knpv	30	32	.	.	.
cord-301128-woe6knpv	31	1	Most	Most	JJS
cord-301128-woe6knpv	31	2	plausible	plausible	JJ
cord-301128-woe6knpv	31	3	models	model	NNS
cord-301128-woe6knpv	31	4	for	for	IN
cord-301128-woe6knpv	31	5	the	the	DT
cord-301128-woe6knpv	31	6	formation	formation	NN
cord-301128-woe6knpv	31	7	of	of	IN
cord-301128-woe6knpv	31	8	topological	topological	JJ
cord-301128-woe6knpv	31	9	barriers	barrier	NNS
cord-301128-woe6knpv	31	10	are	be	VBP
cord-301128-woe6knpv	31	11	(	(	-LRB-
cord-301128-woe6knpv	31	12	i	i	NN
cord-301128-woe6knpv	31	13	)	)	-RRB-
cord-301128-woe6knpv	31	14	actively	actively	RB
cord-301128-woe6knpv	31	15	transcribing	transcribe	VBG
cord-301128-woe6knpv	31	16	RNAP	RNAP	NNP
cord-301128-woe6knpv	31	17	,	,	,
cord-301128-woe6knpv	31	18	which	which	WDT
cord-301128-woe6knpv	31	19	generate	generate	VBP
cord-301128-woe6knpv	31	20	both	both	DT
cord-301128-woe6knpv	31	21	positive	positive	JJ
cord-301128-woe6knpv	31	22	and	and	CC
cord-301128-woe6knpv	31	23	negative	negative	JJ
cord-301128-woe6knpv	31	24	supercoils	supercoil	NNS
cord-301128-woe6knpv	31	25	(	(	-LRB-
cord-301128-woe6knpv	31	26	10	10	CD
cord-301128-woe6knpv	31	27	)	)	-RRB-
cord-301128-woe6knpv	31	28	and	and	CC
cord-301128-woe6knpv	31	29	may	may	MD
cord-301128-woe6knpv	31	30	consequently	consequently	RB
cord-301128-woe6knpv	31	31	block	block	VB
cord-301128-woe6knpv	31	32	the	the	DT
cord-301128-woe6knpv	31	33	displacement	displacement	NN
cord-301128-woe6knpv	31	34	and	and	CC
cord-301128-woe6knpv	31	35	dissipation	dissipation	NN
cord-301128-woe6knpv	31	36	of	of	IN
cord-301128-woe6knpv	31	37	plectonemes	plectonemes	NNP
cord-301128-woe6knpv	31	38	(	(	-LRB-
cord-301128-woe6knpv	31	39	11	11	CD
cord-301128-woe6knpv	31	40	,	,	,
cord-301128-woe6knpv	31	41	12	12	CD
cord-301128-woe6knpv	31	42	)	)	-RRB-
cord-301128-woe6knpv	31	43	,	,	,
cord-301128-woe6knpv	31	44	and	and	CC
cord-301128-woe6knpv	31	45	(	(	-LRB-
cord-301128-woe6knpv	31	46	ii	ii	NN
cord-301128-woe6knpv	31	47	)	)	-RRB-
cord-301128-woe6knpv	31	48	formation	formation	NN
cord-301128-woe6knpv	31	49	of	of	IN
cord-301128-woe6knpv	31	50	DNA	dna	NN
cord-301128-woe6knpv	31	51	loops	loop	NNS
cord-301128-woe6knpv	31	52	by	by	IN
cord-301128-woe6knpv	31	53	certain	certain	JJ
cord-301128-woe6knpv	31	54	nucleoid	nucleoid	NN
cord-301128-woe6knpv	31	55	proteins	protein	NNS
cord-301128-woe6knpv	31	56	,	,	,
cord-301128-woe6knpv	31	57	which	which	WDT
cord-301128-woe6knpv	31	58	may	may	MD
cord-301128-woe6knpv	31	59	serve	serve	VB
cord-301128-woe6knpv	31	60	as	as	IN
cord-301128-woe6knpv	31	61	topological	topological	JJ
cord-301128-woe6knpv	31	62	barriers	barrier	NNS
cord-301128-woe6knpv	31	63	(	(	-LRB-
cord-301128-woe6knpv	31	64	13	13	CD
cord-301128-woe6knpv	31	65	-	-	SYM
cord-301128-woe6knpv	31	66	16	16	CD
cord-301128-woe6knpv	31	67	)	)	-RRB-
cord-301128-woe6knpv	31	68	.	.	.
cord-301128-woe6knpv	32	1	In	in	IN
cord-301128-woe6knpv	32	2	the	the	DT
cord-301128-woe6knpv	32	3	present	present	JJ
cord-301128-woe6knpv	32	4	paper	paper	NN
cord-301128-woe6knpv	32	5	,	,	,
cord-301128-woe6knpv	32	6	we	-PRON-	PRP
cord-301128-woe6knpv	32	7	focus	focus	VBP
cord-301128-woe6knpv	32	8	on	on	IN
cord-301128-woe6knpv	32	9	this	this	DT
cord-301128-woe6knpv	32	10	latter	latter	JJ
cord-301128-woe6knpv	32	11	mechanism	mechanism	NN
cord-301128-woe6knpv	32	12	and	and	CC
cord-301128-woe6knpv	32	13	establish	establish	VB
cord-301128-woe6knpv	32	14	under	under	IN
cord-301128-woe6knpv	32	15	which	which	WDT
cord-301128-woe6knpv	32	16	conditions	condition	NNS
cord-301128-woe6knpv	32	17	DNA	dna	NN
cord-301128-woe6knpv	32	18	-	-	HYPH
cord-301128-woe6knpv	32	19	bridging	bridge	VBG
cord-301128-woe6knpv	32	20	proteins	protein	NNS
cord-301128-woe6knpv	32	21	may	may	MD
cord-301128-woe6knpv	32	22	serve	serve	VB
cord-301128-woe6knpv	32	23	as	as	IN
cord-301128-woe6knpv	32	24	topological	topological	JJ
cord-301128-woe6knpv	32	25	barriers	barrier	NNS
cord-301128-woe6knpv	32	26	.	.	.
cord-301128-woe6knpv	33	1	Several	several	JJ
cord-301128-woe6knpv	33	2	DNA	dna	NN
cord-301128-woe6knpv	33	3	-	-	HYPH
cord-301128-woe6knpv	33	4	bridging	bridge	VBG
cord-301128-woe6knpv	33	5	proteins	protein	NNS
cord-301128-woe6knpv	33	6	have	have	VBP
cord-301128-woe6knpv	33	7	been	be	VBN
cord-301128-woe6knpv	33	8	studied	study	VBN
cord-301128-woe6knpv	33	9	in	in	IN
cord-301128-woe6knpv	33	10	some	some	DT
cord-301128-woe6knpv	33	11	detail	detail	NN
cord-301128-woe6knpv	33	12	,	,	,
cord-301128-woe6knpv	33	13	including	include	VBG
cord-301128-woe6knpv	33	14	transcription	transcription	NN
cord-301128-woe6knpv	33	15	regulators	regulator	NNS
cord-301128-woe6knpv	33	16	like	like	IN
cord-301128-woe6knpv	33	17	the	the	DT
cord-301128-woe6knpv	33	18	LacI	LacI	NNP
cord-301128-woe6knpv	33	19	repressor	repressor	NN
cord-301128-woe6knpv	33	20	(	(	-LRB-
cord-301128-woe6knpv	33	21	17	17	CD
cord-301128-woe6knpv	33	22	)	)	-RRB-
cord-301128-woe6knpv	33	23	,	,	,
cord-301128-woe6knpv	33	24	H	H	NNP
cord-301128-woe6knpv	33	25	-	-	HYPH
cord-301128-woe6knpv	33	26	NS	NS	NNP
cord-301128-woe6knpv	33	27	(	(	-LRB-
cord-301128-woe6knpv	33	28	18	18	CD
cord-301128-woe6knpv	33	29	)	)	-RRB-
cord-301128-woe6knpv	33	30	and	and	CC
cord-301128-woe6knpv	33	31	H	H	NNP
cord-301128-woe6knpv	33	32	-	-	HYPH
cord-301128-woe6knpv	33	33	NS	NS	NNP
cord-301128-woe6knpv	33	34	-	-	HYPH
cord-301128-woe6knpv	33	35	like	like	JJ
cord-301128-woe6knpv	33	36	proteins	protein	NNS
cord-301128-woe6knpv	33	37	(	(	-LRB-
cord-301128-woe6knpv	33	38	19	19	CD
cord-301128-woe6knpv	33	39	)	)	-RRB-
cord-301128-woe6knpv	33	40	,	,	,
cord-301128-woe6knpv	33	41	Lsr2	Lsr2	NNP
cord-301128-woe6knpv	33	42	(	(	-LRB-
cord-301128-woe6knpv	33	43	20	20	CD
cord-301128-woe6knpv	33	44	)	)	-RRB-
cord-301128-woe6knpv	33	45	,	,	,
cord-301128-woe6knpv	33	46	Fis	Fis	NNP
cord-301128-woe6knpv	33	47	(	(	-LRB-
cord-301128-woe6knpv	33	48	21	21	CD
cord-301128-woe6knpv	33	49	)	)	-RRB-
cord-301128-woe6knpv	33	50	and	and	CC
cord-301128-woe6knpv	33	51	Lrp	Lrp	NNP
cord-301128-woe6knpv	33	52	(	(	-LRB-
cord-301128-woe6knpv	33	53	22	22	CD
cord-301128-woe6knpv	33	54	)	)	-RRB-
cord-301128-woe6knpv	33	55	.	.	.
cord-301128-woe6knpv	34	1	In	in	IN
cord-301128-woe6knpv	34	2	their	-PRON-	PRP$
cord-301128-woe6knpv	34	3	functional	functional	JJ
cord-301128-woe6knpv	34	4	form	form	NN
cord-301128-woe6knpv	34	5	,	,	,
cord-301128-woe6knpv	34	6	all	all	DT
cord-301128-woe6knpv	34	7	of	of	IN
cord-301128-woe6knpv	34	8	these	these	DT
cord-301128-woe6knpv	34	9	proteins	protein	NNS
cord-301128-woe6knpv	34	10	have	have	VBP
cord-301128-woe6knpv	34	11	at	at	RB
cord-301128-woe6knpv	34	12	least	least	RBS
cord-301128-woe6knpv	34	13	two	two	CD
cord-301128-woe6knpv	34	14	independent	independent	JJ
cord-301128-woe6knpv	34	15	DNA	dna	NN
cord-301128-woe6knpv	34	16	-	-	HYPH
cord-301128-woe6knpv	34	17	binding	bind	VBG
cord-301128-woe6knpv	34	18	domains	domain	NNS
cord-301128-woe6knpv	34	19	,	,	,
cord-301128-woe6knpv	34	20	so	so	IN
cord-301128-woe6knpv	34	21	that	that	IN
cord-301128-woe6knpv	34	22	they	-PRON-	PRP
cord-301128-woe6knpv	34	23	can	can	MD
cord-301128-woe6knpv	34	24	interact	interact	VB
cord-301128-woe6knpv	34	25	with	with	IN
cord-301128-woe6knpv	34	26	two	two	CD
cord-301128-woe6knpv	34	27	DNA	dna	NN
cord-301128-woe6knpv	34	28	duplexes	duplex	NNS
cord-301128-woe6knpv	34	29	simultaneously	simultaneously	RB
cord-301128-woe6knpv	34	30	and	and	CC
cord-301128-woe6knpv	34	31	form	form	VB
cord-301128-woe6knpv	34	32	a	a	DT
cord-301128-woe6knpv	34	33	bridge	bridge	NN
cord-301128-woe6knpv	34	34	between	between	IN
cord-301128-woe6knpv	34	35	two	two	CD
cord-301128-woe6knpv	34	36	sites	site	NNS
cord-301128-woe6knpv	34	37	that	that	WDT
cord-301128-woe6knpv	34	38	are	be	VBP
cord-301128-woe6knpv	34	39	widely	widely	RB
cord-301128-woe6knpv	34	40	separated	separate	VBN
cord-301128-woe6knpv	34	41	from	from	IN
cord-301128-woe6knpv	34	42	the	the	DT
cord-301128-woe6knpv	34	43	genomic	genomic	JJ
cord-301128-woe6knpv	34	44	point	point	NN
cord-301128-woe6knpv	34	45	of	of	IN
cord-301128-woe6knpv	34	46	view	view	NN
cord-301128-woe6knpv	34	47	.	.	.
cord-301128-woe6knpv	35	1	Most	Most	JJS
cord-301128-woe6knpv	35	2	of	of	IN
cord-301128-woe6knpv	35	3	these	these	DT
cord-301128-woe6knpv	35	4	proteins	protein	NNS
cord-301128-woe6knpv	35	5	also	also	RB
cord-301128-woe6knpv	35	6	bind	bind	VBP
cord-301128-woe6knpv	35	7	non	non	NN
cord-301128-woe6knpv	35	8	-	-	JJ
cord-301128-woe6knpv	35	9	specifically	specifically	RB
cord-301128-woe6knpv	35	10	but	but	CC
cord-301128-woe6knpv	35	11	with	with	IN
cord-301128-woe6knpv	35	12	high	high	JJ
cord-301128-woe6knpv	35	13	affinity	affinity	NN
cord-301128-woe6knpv	35	14	to	to	IN
cord-301128-woe6knpv	35	15	the	the	DT
cord-301128-woe6knpv	35	16	DNA	dna	NN
cord-301128-woe6knpv	35	17	molecule	molecule	NN
cord-301128-woe6knpv	35	18	.	.	.
cord-301128-woe6knpv	36	1	However	however	RB
cord-301128-woe6knpv	36	2	,	,	,
cord-301128-woe6knpv	36	3	among	among	IN
cord-301128-woe6knpv	36	4	all	all	PDT
cord-301128-woe6knpv	36	5	these	these	DT
cord-301128-woe6knpv	36	6	DNA	dna	NN
cord-301128-woe6knpv	36	7	-	-	HYPH
cord-301128-woe6knpv	36	8	bridging	bridge	VBG
cord-301128-woe6knpv	36	9	proteins	protein	NNS
cord-301128-woe6knpv	36	10	,	,	,
cord-301128-woe6knpv	36	11	LacI	LacI	NNP
cord-301128-woe6knpv	36	12	is	be	VBZ
cord-301128-woe6knpv	36	13	to	to	IN
cord-301128-woe6knpv	36	14	date	date	NN
cord-301128-woe6knpv	36	15	the	the	DT
cord-301128-woe6knpv	36	16	only	only	JJ
cord-301128-woe6knpv	36	17	one	one	CD
cord-301128-woe6knpv	36	18	that	that	WDT
cord-301128-woe6knpv	36	19	has	have	VBZ
cord-301128-woe6knpv	36	20	been	be	VBN
cord-301128-woe6knpv	36	21	proved	prove	VBN
cord-301128-woe6knpv	36	22	to	to	TO
cord-301128-woe6knpv	36	23	work	work	VB
cord-301128-woe6knpv	36	24	as	as	IN
cord-301128-woe6knpv	36	25	a	a	DT
cord-301128-woe6knpv	36	26	topological	topological	JJ
cord-301128-woe6knpv	36	27	barrier	barrier	NN
cord-301128-woe6knpv	36	28	(	(	-LRB-
cord-301128-woe6knpv	36	29	15	15	CD
cord-301128-woe6knpv	36	30	,	,	,
cord-301128-woe6knpv	36	31	23	23	CD
cord-301128-woe6knpv	36	32	,	,	,
cord-301128-woe6knpv	36	33	24	24	CD
cord-301128-woe6knpv	36	34	)	)	-RRB-
cord-301128-woe6knpv	36	35	.	.	.
cord-301128-woe6knpv	37	1	The	the	DT
cord-301128-woe6knpv	37	2	guiding	guide	VBG
cord-301128-woe6knpv	37	3	line	line	NN
cord-301128-woe6knpv	37	4	of	of	IN
cord-301128-woe6knpv	37	5	the	the	DT
cord-301128-woe6knpv	37	6	present	present	JJ
cord-301128-woe6knpv	37	7	paper	paper	NN
cord-301128-woe6knpv	37	8	is	be	VBZ
cord-301128-woe6knpv	37	9	consequently	consequently	RB
cord-301128-woe6knpv	37	10	the	the	DT
cord-301128-woe6knpv	37	11	experimental	experimental	JJ
cord-301128-woe6knpv	37	12	demonstration	demonstration	NN
cord-301128-woe6knpv	37	13	in	in	IN
cord-301128-woe6knpv	37	14	(	(	-LRB-
cord-301128-woe6knpv	37	15	15	15	CD
cord-301128-woe6knpv	37	16	)	)	-RRB-
cord-301128-woe6knpv	37	17	that	that	IN
cord-301128-woe6knpv	37	18	the	the	DT
cord-301128-woe6knpv	37	19	binding	binding	NN
cord-301128-woe6knpv	37	20	of	of	IN
cord-301128-woe6knpv	37	21	a	a	DT
cord-301128-woe6knpv	37	22	DNA	dna	NN
cord-301128-woe6knpv	37	23	-	-	HYPH
cord-301128-woe6knpv	37	24	binding	bind	VBG
cord-301128-woe6knpv	37	25	protein	protein	NN
cord-301128-woe6knpv	37	26	to	to	IN
cord-301128-woe6knpv	37	27	its	-PRON-	PRP$
cord-301128-woe6knpv	37	28	recognition	recognition	NN
cord-301128-woe6knpv	37	29	sites	site	NNS
cord-301128-woe6knpv	37	30	in	in	IN
cord-301128-woe6knpv	37	31	two	two	CD
cord-301128-woe6knpv	37	32	different	different	JJ
cord-301128-woe6knpv	37	33	locations	location	NNS
cord-301128-woe6knpv	37	34	on	on	IN
cord-301128-woe6knpv	37	35	a	a	DT
cord-301128-woe6knpv	37	36	supercoiled	supercoiled	JJ
cord-301128-woe6knpv	37	37	DNA	dna	NN
cord-301128-woe6knpv	37	38	molecule	molecule	NN
cord-301128-woe6knpv	37	39	can	can	MD
cord-301128-woe6knpv	37	40	confine	confine	VB
cord-301128-woe6knpv	37	41	free	free	JJ
cord-301128-woe6knpv	37	42	supercoils	supercoil	NNS
cord-301128-woe6knpv	37	43	to	to	IN
cord-301128-woe6knpv	37	44	a	a	DT
cord-301128-woe6knpv	37	45	defined	define	VBN
cord-301128-woe6knpv	37	46	region	region	NN
cord-301128-woe6knpv	37	47	and	and	CC
cord-301128-woe6knpv	37	48	divide	divide	VB
cord-301128-woe6knpv	37	49	the	the	DT
cord-301128-woe6knpv	37	50	DNA	dna	NN
cord-301128-woe6knpv	37	51	molecule	molecule	NN
cord-301128-woe6knpv	37	52	into	into	IN
cord-301128-woe6knpv	37	53	two	two	CD
cord-301128-woe6knpv	37	54	distinct	distinct	JJ
cord-301128-woe6knpv	37	55	topological	topological	JJ
cord-301128-woe6knpv	37	56	domains	domain	NNS
cord-301128-woe6knpv	37	57	(	(	-LRB-
cord-301128-woe6knpv	37	58	15	15	CD
cord-301128-woe6knpv	37	59	)	)	-RRB-
cord-301128-woe6knpv	37	60	.	.	.
cord-301128-woe6knpv	38	1	In	in	IN
cord-301128-woe6knpv	38	2	order	order	NN
cord-301128-woe6knpv	38	3	to	to	TO
cord-301128-woe6knpv	38	4	gain	gain	VB
cord-301128-woe6knpv	38	5	more	more	RBR
cord-301128-woe6knpv	38	6	detailed	detailed	JJ
cord-301128-woe6knpv	38	7	information	information	NN
cord-301128-woe6knpv	38	8	on	on	IN
cord-301128-woe6knpv	38	9	this	this	DT
cord-301128-woe6knpv	38	10	mechanism	mechanism	NN
cord-301128-woe6knpv	38	11	,	,	,
cord-301128-woe6knpv	38	12	we	-PRON-	PRP
cord-301128-woe6knpv	38	13	determined	determine	VBD
cord-301128-woe6knpv	38	14	the	the	DT
cord-301128-woe6knpv	38	15	minimal	minimal	JJ
cord-301128-woe6knpv	38	16	physical	physical	JJ
cord-301128-woe6knpv	38	17	properties	property	NNS
cord-301128-woe6knpv	38	18	that	that	WDT
cord-301128-woe6knpv	38	19	must	must	MD
cord-301128-woe6knpv	38	20	be	be	VB
cord-301128-woe6knpv	38	21	added	add	VBN
cord-301128-woe6knpv	38	22	to	to	IN
cord-301128-woe6knpv	38	23	a	a	DT
cord-301128-woe6knpv	38	24	standard	standard	JJ
cord-301128-woe6knpv	38	25	model	model	NN
cord-301128-woe6knpv	38	26	of	of	IN
cord-301128-woe6knpv	38	27	circular	circular	JJ
cord-301128-woe6knpv	38	28	DNA	dna	NN
cord-301128-woe6knpv	38	29	to	to	TO
cord-301128-woe6knpv	38	30	reproduce	reproduce	VB
cord-301128-woe6knpv	38	31	the	the	DT
cord-301128-woe6knpv	38	32	results	result	NNS
cord-301128-woe6knpv	38	33	described	describe	VBN
cord-301128-woe6knpv	38	34	in	in	IN
cord-301128-woe6knpv	38	35	(	(	-LRB-
cord-301128-woe6knpv	38	36	15	15	CD
cord-301128-woe6knpv	38	37	)	)	-RRB-
cord-301128-woe6knpv	38	38	.	.	.
cord-301128-woe6knpv	39	1	The	the	DT
cord-301128-woe6knpv	39	2	starting	starting	NN
cord-301128-woe6knpv	39	3	model	model	NN
cord-301128-woe6knpv	39	4	for	for	IN
cord-301128-woe6knpv	39	5	this	this	DT
cord-301128-woe6knpv	39	6	study	study	NN
cord-301128-woe6knpv	39	7	was	be	VBD
cord-301128-woe6knpv	39	8	similar	similar	JJ
cord-301128-woe6knpv	39	9	to	to	IN
cord-301128-woe6knpv	39	10	those	those	DT
cord-301128-woe6knpv	39	11	we	-PRON-	PRP
cord-301128-woe6knpv	39	12	proposed	propose	VBD
cord-301128-woe6knpv	39	13	recently	recently	RB
cord-301128-woe6knpv	39	14	to	to	TO
cord-301128-woe6knpv	39	15	investigate	investigate	VB
cord-301128-woe6knpv	39	16	facilitated	facilitate	VBN
cord-301128-woe6knpv	39	17	diffusion	diffusion	NN
cord-301128-woe6knpv	39	18	(	(	-LRB-
cord-301128-woe6knpv	39	19	25	25	CD
cord-301128-woe6knpv	39	20	)	)	-RRB-
cord-301128-woe6knpv	39	21	(	(	-LRB-
cord-301128-woe6knpv	39	22	26	26	CD
cord-301128-woe6knpv	39	23	)	)	-RRB-
cord-301128-woe6knpv	39	24	(	(	-LRB-
cord-301128-woe6knpv	39	25	27	27	CD
cord-301128-woe6knpv	39	26	)	)	-RRB-
cord-301128-woe6knpv	39	27	,	,	,
cord-301128-woe6knpv	39	28	the	the	DT
cord-301128-woe6knpv	39	29	interactions	interaction	NNS
cord-301128-woe6knpv	39	30	of	of	IN
cord-301128-woe6knpv	39	31	DNA	dna	NN
cord-301128-woe6knpv	39	32	and	and	CC
cord-301128-woe6knpv	39	33	H	H	NNP
cord-301128-woe6knpv	39	34	-	-	HYPH
cord-301128-woe6knpv	39	35	NS	NS	NNP
cord-301128-woe6knpv	39	36	nucleoid	nucleoid	NNP
cord-301128-woe6knpv	39	37	proteins	protein	NNS
cord-301128-woe6knpv	39	38	(	(	-LRB-
cord-301128-woe6knpv	39	39	28	28	CD
cord-301128-woe6knpv	39	40	)	)	-RRB-
cord-301128-woe6knpv	39	41	(	(	-LRB-
cord-301128-woe6knpv	39	42	29	29	CD
cord-301128-woe6knpv	39	43	)	)	-RRB-
cord-301128-woe6knpv	39	44	(	(	-LRB-
cord-301128-woe6knpv	39	45	30	30	CD
cord-301128-woe6knpv	39	46	)	)	-RRB-
cord-301128-woe6knpv	39	47	,	,	,
cord-301128-woe6knpv	39	48	the	the	DT
cord-301128-woe6knpv	39	49	formation	formation	NN
cord-301128-woe6knpv	39	50	of	of	IN
cord-301128-woe6knpv	39	51	the	the	DT
cord-301128-woe6knpv	39	52	bacterial	bacterial	JJ
cord-301128-woe6knpv	39	53	nucleoid	nucleoid	NNP
cord-301128-woe6knpv	39	54	(	(	-LRB-
cord-301128-woe6knpv	39	55	31	31	CD
cord-301128-woe6knpv	39	56	)	)	-RRB-
cord-301128-woe6knpv	39	57	(	(	-LRB-
cord-301128-woe6knpv	39	58	32	32	CD
cord-301128-woe6knpv	39	59	)	)	-RRB-
cord-301128-woe6knpv	39	60	(	(	-LRB-
cord-301128-woe6knpv	39	61	33	33	CD
cord-301128-woe6knpv	39	62	)	)	-RRB-
cord-301128-woe6knpv	39	63	(	(	-LRB-
cord-301128-woe6knpv	39	64	34	34	CD
cord-301128-woe6knpv	39	65	)	)	-RRB-
cord-301128-woe6knpv	39	66	(	(	-LRB-
cord-301128-woe6knpv	39	67	35	35	CD
cord-301128-woe6knpv	39	68	)	)	-RRB-
cord-301128-woe6knpv	39	69	,	,	,
cord-301128-woe6knpv	39	70	and	and	CC
cord-301128-woe6knpv	39	71	the	the	DT
cord-301128-woe6knpv	39	72	interplay	interplay	NN
cord-301128-woe6knpv	39	73	of	of	IN
cord-301128-woe6knpv	39	74	DNA	dna	NN
cord-301128-woe6knpv	39	75	demixing	demixing	NN
cord-301128-woe6knpv	39	76	and	and	CC
cord-301128-woe6knpv	39	77	supercoiling	supercoile	VBG
cord-301128-woe6knpv	39	78	in	in	IN
cord-301128-woe6knpv	39	79	compacting	compact	VBG
cord-301128-woe6knpv	39	80	the	the	DT
cord-301128-woe6knpv	39	81	nucleoid	nucleoid	NNP
cord-301128-woe6knpv	39	82	(	(	-LRB-
cord-301128-woe6knpv	39	83	36	36	CD
cord-301128-woe6knpv	39	84	)	)	-RRB-
cord-301128-woe6knpv	39	85	.	.	.
cord-301128-woe6knpv	40	1	The	the	DT
cord-301128-woe6knpv	40	2	results	result	NNS
cord-301128-woe6knpv	40	3	presented	present	VBN
cord-301128-woe6knpv	40	4	in	in	IN
cord-301128-woe6knpv	40	5	this	this	DT
cord-301128-woe6knpv	40	6	article	article	NN
cord-301128-woe6knpv	40	7	reveal	reveal	VBP
cord-301128-woe6knpv	40	8	that	that	IN
cord-301128-woe6knpv	40	9	the	the	DT
cord-301128-woe6knpv	40	10	formation	formation	NN
cord-301128-woe6knpv	40	11	of	of	IN
cord-301128-woe6knpv	40	12	DNA	dna	NN
cord-301128-woe6knpv	40	13	loops	loop	NNS
cord-301128-woe6knpv	40	14	is	be	VBZ
cord-301128-woe6knpv	40	15	by	by	IN
cord-301128-woe6knpv	40	16	no	no	DT
cord-301128-woe6knpv	40	17	means	means	NN
cord-301128-woe6knpv	40	18	sufficient	sufficient	JJ
cord-301128-woe6knpv	40	19	to	to	TO
cord-301128-woe6knpv	40	20	create	create	VB
cord-301128-woe6knpv	40	21	topologically	topologically	RB
cord-301128-woe6knpv	40	22	independent	independent	JJ
cord-301128-woe6knpv	40	23	domains	domain	NNS
cord-301128-woe6knpv	40	24	and	and	CC
cord-301128-woe6knpv	40	25	that	that	IN
cord-301128-woe6knpv	40	26	DNA	dna	NN
cord-301128-woe6knpv	40	27	-	-	HYPH
cord-301128-woe6knpv	40	28	bridging	bridge	VBG
cord-301128-woe6knpv	40	29	proteins	protein	NNS
cord-301128-woe6knpv	40	30	must	must	MD
cord-301128-woe6knpv	40	31	exert	exert	VB
cord-301128-woe6knpv	40	32	rather	rather	RB
cord-301128-woe6knpv	40	33	strong	strong	JJ
cord-301128-woe6knpv	40	34	constraints	constraint	NNS
cord-301128-woe6knpv	40	35	on	on	IN
cord-301128-woe6knpv	40	36	their	-PRON-	PRP$
cord-301128-woe6knpv	40	37	binding	bind	VBG
cord-301128-woe6knpv	40	38	sites	site	NNS
cord-301128-woe6knpv	40	39	in	in	IN
cord-301128-woe6knpv	40	40	order	order	NN
cord-301128-woe6knpv	40	41	to	to	TO
cord-301128-woe6knpv	40	42	act	act	VB
cord-301128-woe6knpv	40	43	as	as	IN
cord-301128-woe6knpv	40	44	topological	topological	JJ
cord-301128-woe6knpv	40	45	barriers	barrier	NNS
cord-301128-woe6knpv	40	46	:	:	:
cord-301128-woe6knpv	40	47	They	-PRON-	PRP
cord-301128-woe6knpv	40	48	must	must	MD
cord-301128-woe6knpv	40	49	block	block	VB
cord-301128-woe6knpv	40	50	the	the	DT
cord-301128-woe6knpv	40	51	diffusion	diffusion	NN
cord-301128-woe6knpv	40	52	of	of	IN
cord-301128-woe6knpv	40	53	the	the	DT
cord-301128-woe6knpv	40	54	excess	excess	NN
cord-301128-woe6knpv	40	55	of	of	IN
cord-301128-woe6knpv	40	56	twist	twist	NN
cord-301128-woe6knpv	40	57	through	through	IN
cord-301128-woe6knpv	40	58	both	both	DT
cord-301128-woe6knpv	40	59	binding	bind	VBG
cord-301128-woe6knpv	40	60	sites	site	NNS
cord-301128-woe6knpv	40	61	and	and	CC
cord-301128-woe6knpv	40	62	must	must	MD
cord-301128-woe6knpv	40	63	additionally	additionally	RB
cord-301128-woe6knpv	40	64	block	block	VB
cord-301128-woe6knpv	40	65	the	the	DT
cord-301128-woe6knpv	40	66	rotation	rotation	NN
cord-301128-woe6knpv	40	67	of	of	IN
cord-301128-woe6knpv	40	68	one	one	CD
cord-301128-woe6knpv	40	69	DNA	dna	NN
cord-301128-woe6knpv	40	70	segment	segment	NN
cord-301128-woe6knpv	40	71	relative	relative	JJ
cord-301128-woe6knpv	40	72	to	to	IN
cord-301128-woe6knpv	40	73	the	the	DT
cord-301128-woe6knpv	40	74	other	other	JJ
cord-301128-woe6knpv	40	75	one	one	NN
cord-301128-woe6knpv	40	76	.	.	.
cord-301128-woe6knpv	41	1	The	the	DT
cord-301128-woe6knpv	41	2	coarse	coarse	RB
cord-301128-woe6knpv	41	3	-	-	HYPH
cord-301128-woe6knpv	41	4	grained	grained	JJ
cord-301128-woe6knpv	41	5	bead	bead	NN
cord-301128-woe6knpv	41	6	-	-	HYPH
cord-301128-woe6knpv	41	7	and	and	CC
cord-301128-woe6knpv	41	8	-	-	HYPH
cord-301128-woe6knpv	41	9	spring	spring	NN
cord-301128-woe6knpv	41	10	model	model	NN
cord-301128-woe6knpv	41	11	developed	develop	VBN
cord-301128-woe6knpv	41	12	for	for	IN
cord-301128-woe6knpv	41	13	the	the	DT
cord-301128-woe6knpv	41	14	present	present	JJ
cord-301128-woe6knpv	41	15	study	study	NN
cord-301128-woe6knpv	41	16	is	be	VBZ
cord-301128-woe6knpv	41	17	described	describe	VBN
cord-301128-woe6knpv	41	18	in	in	IN
cord-301128-woe6knpv	41	19	detail	detail	NN
cord-301128-woe6knpv	41	20	in	in	IN
cord-301128-woe6knpv	41	21	Model	Model	NNP
cord-301128-woe6knpv	41	22	and	and	CC
cord-301128-woe6knpv	41	23	Simulations	Simulations	NNPS
cord-301128-woe6knpv	41	24	in	in	IN
cord-301128-woe6knpv	41	25	the	the	DT
cord-301128-woe6knpv	41	26	Supporting	Supporting	NNP
cord-301128-woe6knpv	41	27	Material	Material	NNP
cord-301128-woe6knpv	41	28	.	.	.
cord-301128-woe6knpv	42	1	In	in	IN
cord-301128-woe6knpv	42	2	brief	brief	JJ
cord-301128-woe6knpv	42	3	,	,	,
cord-301128-woe6knpv	42	4	bacterial	bacterial	JJ
cord-301128-woe6knpv	42	5	DNA	dna	NN
cord-301128-woe6knpv	42	6	is	be	VBZ
cord-301128-woe6knpv	42	7	modeled	model	VBN
cord-301128-woe6knpv	42	8	,	,	,
cord-301128-woe6knpv	42	9	as	as	IN
cord-301128-woe6knpv	42	10	in	in	IN
cord-301128-woe6knpv	42	11	(	(	-LRB-
cord-301128-woe6knpv	42	12	30	30	CD
cord-301128-woe6knpv	42	13	,	,	,
cord-301128-woe6knpv	42	14	36	36	CD
cord-301128-woe6knpv	42	15	)	)	-RRB-
cord-301128-woe6knpv	42	16	,	,	,
cord-301128-woe6knpv	42	17	as	as	IN
cord-301128-woe6knpv	42	18	circular	circular	JJ
cord-301128-woe6knpv	42	19	chains	chain	NNS
cord-301128-woe6knpv	42	20	of	of	IN
cord-301128-woe6knpv	42	21	n	n	CD
cord-301128-woe6knpv	42	22	beads	bead	NNS
cord-301128-woe6knpv	42	23	with	with	IN
cord-301128-woe6knpv	42	24	radius	radius	NN
cord-301128-woe6knpv	42	25	0	0	CD
cord-301128-woe6knpv	42	26	.	.	.
cord-301128-woe6knpv	43	1	As	as	IN
cord-301128-woe6knpv	43	2	in	in	IN
cord-301128-woe6knpv	43	3	(	(	-LRB-
cord-301128-woe6knpv	43	4	31	31	CD
cord-301128-woe6knpv	43	5	,	,	,
cord-301128-woe6knpv	43	6	36	36	CD
cord-301128-woe6knpv	43	7	)	)	-RRB-
cord-301128-woe6knpv	43	8	,	,	,
cord-301128-woe6knpv	43	9	the	the	DT
cord-301128-woe6knpv	43	10	torsional	torsional	NNP
cord-301128-woe6knpv	43	11	energy	energy	NN
cord-301128-woe6knpv	43	12	term	term	NN
cord-301128-woe6knpv	43	13	was	be	VBD
cord-301128-woe6knpv	43	14	borrowed	borrow	VBN
cord-301128-woe6knpv	43	15	from	from	IN
cord-301128-woe6knpv	43	16	(	(	-LRB-
cord-301128-woe6knpv	43	17	37	37	CD
cord-301128-woe6knpv	43	18	)	)	-RRB-
cord-301128-woe6knpv	43	19	and	and	CC
cord-301128-woe6knpv	43	20	requires	require	VBZ
cord-301128-woe6knpv	43	21	the	the	DT
cord-301128-woe6knpv	43	22	introduction	introduction	NN
cord-301128-woe6knpv	43	23	of	of	IN
cord-301128-woe6knpv	43	24	a	a	DT
cord-301128-woe6knpv	43	25	body	body	NN
cord-301128-woe6knpv	43	26	-	-	HYPH
cord-301128-woe6knpv	43	27	fixed	fix	VBN
cord-301128-woe6knpv	43	28	frame	frame	NN
cord-301128-woe6knpv	43	29	(	(	-LRB-
cord-301128-woe6knpv	43	30	,	,	,
cord-301128-woe6knpv	43	31	,	,	,
cord-301128-woe6knpv	43	32	)	)	-RRB-
cord-301128-woe6knpv	44	1	k	k	NNP
cord-301128-woe6knpv	44	2	k	k	NNP
cord-301128-woe6knpv	44	3	k	k	NNP
cord-301128-woe6knpv	44	4	u	u	NN
cord-301128-woe6knpv	44	5	f	f	NNP
cord-301128-woe6knpv	44	6	v	v	NN
cord-301128-woe6knpv	44	7	,	,	,
cord-301128-woe6knpv	44	8	where	where	WRB
cord-301128-woe6knpv	44	9	k	k	NNP
cord-301128-woe6knpv	44	10	u	u	NNP
cord-301128-woe6knpv	44	11	denotes	denote	VBZ
cord-301128-woe6knpv	44	12	the	the	DT
cord-301128-woe6knpv	44	13	unit	unit	NN
cord-301128-woe6knpv	44	14	vector	vector	NN
cord-301128-woe6knpv	44	15	pointing	point	VBG
cord-301128-woe6knpv	44	16	from	from	IN
cord-301128-woe6knpv	44	17	bead	bead	NN
cord-301128-woe6knpv	44	18	k	k	NNP
cord-301128-woe6knpv	44	19	to	to	TO
cord-301128-woe6knpv	44	20	bead	bead	NN
cord-301128-woe6knpv	44	21	1	1	CD
cord-301128-woe6knpv	44	22	k	k	NN
cord-301128-woe6knpv	45	1	+	+	UH
cord-301128-woe6knpv	45	2	.	.	.
cord-301128-woe6knpv	46	1	The	the	DT
cord-301128-woe6knpv	46	2	torsional	torsional	JJ
cord-301128-woe6knpv	46	3	rigidity	rigidity	NN
cord-301128-woe6knpv	46	4	opposing	oppose	VBG
cord-301128-woe6knpv	46	5	rotation	rotation	NN
cord-301128-woe6knpv	46	6	of	of	IN
cord-301128-woe6knpv	46	7	(	(	-LRB-
cord-301128-woe6knpv	46	8	,	,	,
cord-301128-woe6knpv	46	9	,	,	,
cord-301128-woe6knpv	46	10	)	)	-RRB-
cord-301128-woe6knpv	46	11	)	)	-RRB-
cord-301128-woe6knpv	46	12	was	be	VBD
cord-301128-woe6knpv	46	13	adjusted	adjust	VBN
cord-301128-woe6knpv	46	14	so	so	IN
cord-301128-woe6knpv	46	15	that	that	IN
cord-301128-woe6knpv	46	16	at	at	IN
cord-301128-woe6knpv	46	17	equilibrium	equilibrium	NN
cord-301128-woe6knpv	46	18	the	the	DT
cord-301128-woe6knpv	46	19	writhe	writhe	NNP
cord-301128-woe6knpv	46	20	contribution	contribution	NN
cord-301128-woe6knpv	46	21	accounts	account	VBZ
cord-301128-woe6knpv	46	22	for	for	IN
cord-301128-woe6knpv	46	23	approximately	approximately	RB
cord-301128-woe6knpv	46	24	70	70	CD
cord-301128-woe6knpv	46	25	%	%	NN
cord-301128-woe6knpv	46	26	of	of	IN
cord-301128-woe6knpv	46	27	the	the	DT
cord-301128-woe6knpv	46	28	linking	link	VBG
cord-301128-woe6knpv	46	29	number	number	NN
cord-301128-woe6knpv	46	30	difference	difference	NN
cord-301128-woe6knpv	46	31	(	(	-LRB-
cord-301128-woe6knpv	46	32	38	38	CD
cord-301128-woe6knpv	46	33	)	)	-RRB-
cord-301128-woe6knpv	46	34	,	,	,
cord-301128-woe6knpv	46	35	as	as	IN
cord-301128-woe6knpv	46	36	is	be	VBZ
cord-301128-woe6knpv	46	37	illustrated	illustrate	VBN
cord-301128-woe6knpv	46	38	in	in	IN
cord-301128-woe6knpv	46	39	Fig	Fig	NNP
cord-301128-woe6knpv	46	40	.	.	.
cord-301128-woe6knpv	46	41	S1	S1	NNP
cord-301128-woe6knpv	46	42	.	.	.
cord-301128-woe6knpv	47	1	The	the	DT
cord-301128-woe6knpv	47	2	values	value	NNS
cord-301128-woe6knpv	47	3	of	of	IN
cord-301128-woe6knpv	47	4	the	the	DT
cord-301128-woe6knpv	47	5	bending	bending	NN
cord-301128-woe6knpv	47	6	and	and	CC
cord-301128-woe6knpv	47	7	torsional	torsional	JJ
cord-301128-woe6knpv	47	8	rigidities	rigidity	NNS
cord-301128-woe6knpv	47	9	are	be	VBP
cord-301128-woe6knpv	47	10	close	close	JJ
cord-301128-woe6knpv	47	11	together	together	RB
cord-301128-woe6knpv	47	12	,	,	,
cord-301128-woe6knpv	47	13	in	in	IN
cord-301128-woe6knpv	47	14	agreement	agreement	NN
cord-301128-woe6knpv	47	15	with	with	IN
cord-301128-woe6knpv	47	16	experimental	experimental	JJ
cord-301128-woe6knpv	47	17	results	result	NNS
cord-301128-woe6knpv	47	18	(	(	-LRB-
cord-301128-woe6knpv	47	19	38	38	CD
cord-301128-woe6knpv	47	20	)	)	-RRB-
cord-301128-woe6knpv	47	21	.	.	.
cord-301128-woe6knpv	48	1	It	-PRON-	PRP
cord-301128-woe6knpv	48	2	may	may	MD
cord-301128-woe6knpv	48	3	be	be	VB
cord-301128-woe6knpv	48	4	worth	worth	JJ
cord-301128-woe6knpv	48	5	emphasizing	emphasize	VBG
cord-301128-woe6knpv	48	6	that	that	IN
cord-301128-woe6knpv	48	7	introduction	introduction	NN
cord-301128-woe6knpv	48	8	of	of	IN
cord-301128-woe6knpv	48	9	the	the	DT
cord-301128-woe6knpv	48	10	body	body	NN
cord-301128-woe6knpv	48	11	-	-	HYPH
cord-301128-woe6knpv	48	12	fixed	fix	VBN
cord-301128-woe6knpv	48	13	frame	frame	NN
cord-301128-woe6knpv	48	14	(	(	-LRB-
cord-301128-woe6knpv	48	15	,	,	,
cord-301128-woe6knpv	48	16	,	,	,
cord-301128-woe6knpv	48	17	)	)	-RRB-
cord-301128-woe6knpv	49	1	k	k	NNP
cord-301128-woe6knpv	50	1	k	k	NNP
cord-301128-woe6knpv	50	2	k	k	NNP
cord-301128-woe6knpv	51	1	u	u	NNP
cord-301128-woe6knpv	51	2	f	f	NNP
cord-301128-woe6knpv	51	3	v	v	NNP
cord-301128-woe6knpv	51	4	is	be	VBZ
cord-301128-woe6knpv	51	5	crucial	crucial	JJ
cord-301128-woe6knpv	51	6	for	for	IN
cord-301128-woe6knpv	51	7	modeling	model	VBG
cord-301128-woe6knpv	51	8	correctly	correctly	RB
cord-301128-woe6knpv	51	9	the	the	DT
cord-301128-woe6knpv	51	10	torsion	torsion	NN
cord-301128-woe6knpv	51	11	of	of	IN
cord-301128-woe6knpv	51	12	double	double	RB
cord-301128-woe6knpv	51	13	-	-	HYPH
cord-301128-woe6knpv	51	14	stranded	strand	VBN
cord-301128-woe6knpv	51	15	DNA	dna	NN
cord-301128-woe6knpv	51	16	with	with	IN
cord-301128-woe6knpv	51	17	a	a	DT
cord-301128-woe6knpv	51	18	"	"	``
cord-301128-woe6knpv	51	19	single	single	JJ
cord-301128-woe6knpv	51	20	-	-	HYPH
cord-301128-woe6knpv	51	21	stranded	stranded	JJ
cord-301128-woe6knpv	51	22	"	"	''
cord-301128-woe6knpv	51	23	bead	bead	NN
cord-301128-woe6knpv	51	24	-	-	HYPH
cord-301128-woe6knpv	51	25	and	and	CC
cord-301128-woe6knpv	51	26	-	-	HYPH
cord-301128-woe6knpv	51	27	spring	spring	NN
cord-301128-woe6knpv	51	28	model	model	NN
cord-301128-woe6knpv	51	29	.	.	.
cord-301128-woe6knpv	52	1	This	this	DT
cord-301128-woe6knpv	52	2	procedure	procedure	NN
cord-301128-woe6knpv	52	3	is	be	VBZ
cord-301128-woe6knpv	52	4	quite	quite	RB
cord-301128-woe6knpv	52	5	realistic	realistic	JJ
cord-301128-woe6knpv	52	6	and	and	CC
cord-301128-woe6knpv	52	7	has	have	VBZ
cord-301128-woe6knpv	52	8	already	already	RB
cord-301128-woe6knpv	52	9	proved	prove	VBN
cord-301128-woe6knpv	52	10	very	very	RB
cord-301128-woe6knpv	52	11	useful	useful	JJ
cord-301128-woe6knpv	52	12	for	for	IN
cord-301128-woe6knpv	52	13	studying	study	VBG
cord-301128-woe6knpv	52	14	,	,	,
cord-301128-woe6knpv	52	15	for	for	IN
cord-301128-woe6knpv	52	16	example	example	NN
cord-301128-woe6knpv	52	17	,	,	,
cord-301128-woe6knpv	52	18	the	the	DT
cord-301128-woe6knpv	52	19	interplay	interplay	NN
cord-301128-woe6knpv	52	20	of	of	IN
cord-301128-woe6knpv	52	21	DNA	dna	NN
cord-301128-woe6knpv	52	22	demixing	demixing	NN
cord-301128-woe6knpv	52	23	and	and	CC
cord-301128-woe6knpv	52	24	supercoiling	supercoile	VBG
cord-301128-woe6knpv	52	25	in	in	IN
cord-301128-woe6knpv	52	26	nucleoid	nucleoid	NNP
cord-301128-woe6knpv	52	27	compaction	compaction	NN
cord-301128-woe6knpv	52	28	(	(	-LRB-
cord-301128-woe6knpv	52	29	36	36	CD
cord-301128-woe6knpv	52	30	)	)	-RRB-
cord-301128-woe6knpv	52	31	,	,	,
cord-301128-woe6knpv	52	32	the	the	DT
cord-301128-woe6knpv	52	33	buckling	buckle	VBG
cord-301128-woe6knpv	52	34	transition	transition	NN
cord-301128-woe6knpv	52	35	in	in	IN
cord-301128-woe6knpv	52	36	double	double	RB
cord-301128-woe6knpv	52	37	-	-	HYPH
cord-301128-woe6knpv	52	38	stranded	stranded	JJ
cord-301128-woe6knpv	52	39	DNA	DNA	NNP
cord-301128-woe6knpv	52	40	and	and	CC
cord-301128-woe6knpv	52	41	RNA	RNA	NNP
cord-301128-woe6knpv	52	42	(	(	-LRB-
cord-301128-woe6knpv	52	43	39	39	CD
cord-301128-woe6knpv	52	44	)	)	-RRB-
cord-301128-woe6knpv	52	45	,	,	,
cord-301128-woe6knpv	52	46	the	the	DT
cord-301128-woe6knpv	52	47	influence	influence	NN
cord-301128-woe6knpv	52	48	of	of	IN
cord-301128-woe6knpv	52	49	nucleoid	nucleoid	JJ
cord-301128-woe6knpv	52	50	-	-	HYPH
cord-301128-woe6knpv	52	51	associated	associate	VBN
cord-301128-woe6knpv	52	52	proteins	protein	NNS
cord-301128-woe6knpv	52	53	on	on	IN
cord-301128-woe6knpv	52	54	DNA	dna	NN
cord-301128-woe6knpv	52	55	supercoiling	supercoiling	NN
cord-301128-woe6knpv	52	56	(	(	-LRB-
cord-301128-woe6knpv	52	57	40	40	CD
cord-301128-woe6knpv	52	58	)	)	-RRB-
cord-301128-woe6knpv	52	59	 	 	_SP
cord-301128-woe6knpv	53	1	As	as	IN
cord-301128-woe6knpv	53	2	a	a	DT
cord-301128-woe6knpv	53	3	starting	starting	NN
cord-301128-woe6knpv	53	4	point	point	NN
cord-301128-woe6knpv	53	5	,	,	,
cord-301128-woe6knpv	53	6	we	-PRON-	PRP
cord-301128-woe6knpv	53	7	recall	recall	VBP
cord-301128-woe6knpv	53	8	the	the	DT
cord-301128-woe6knpv	53	9	experimental	experimental	JJ
cord-301128-woe6knpv	53	10	results	result	NNS
cord-301128-woe6knpv	53	11	in	in	IN
cord-301128-woe6knpv	53	12	(	(	-LRB-
cord-301128-woe6knpv	53	13	15	15	CD
cord-301128-woe6knpv	53	14	)	)	-RRB-
cord-301128-woe6knpv	53	15	,	,	,
cord-301128-woe6knpv	53	16	where	where	WRB
cord-301128-woe6knpv	53	17	the	the	DT
cord-301128-woe6knpv	53	18	torsional	torsional	JJ
cord-301128-woe6knpv	53	19	relaxation	relaxation	NN
cord-301128-woe6knpv	53	20	properties	property	NNS
cord-301128-woe6knpv	53	21	of	of	IN
cord-301128-woe6knpv	53	22	4100	4100	CD
cord-301128-woe6knpv	53	23	bp	bp	NNP
cord-301128-woe6knpv	53	24	plasmids	plasmid	NNS
cord-301128-woe6knpv	53	25	with	with	IN
cord-301128-woe6knpv	53	26	initial	initial	JJ
cord-301128-woe6knpv	53	27	superhelical	superhelical	JJ
cord-301128-woe6knpv	53	28	density	density	NN
cord-301128-woe6knpv	53	29	0.06	0.06	CD
cord-301128-woe6knpv	53	30	Of	of	IN
cord-301128-woe6knpv	53	31	special	special	JJ
cord-301128-woe6knpv	53	32	interest	interest	NN
cord-301128-woe6knpv	53	33	to	to	IN
cord-301128-woe6knpv	53	34	us	-PRON-	PRP
cord-301128-woe6knpv	53	35	were	be	VBD
cord-301128-woe6knpv	53	36	the	the	DT
cord-301128-woe6knpv	53	37	experiments	experiment	NNS
cord-301128-woe6knpv	53	38	performed	perform	VBN
cord-301128-woe6knpv	53	39	with	with	IN
cord-301128-woe6knpv	53	40	plasmids	plasmid	NNS
cord-301128-woe6knpv	53	41	containing	contain	VBG
cord-301128-woe6knpv	53	42	tandem	tandem	JJ
cord-301128-woe6knpv	53	43	copies	copy	NNS
cord-301128-woe6knpv	53	44	of	of	IN
cord-301128-woe6knpv	53	45	the	the	DT
cord-301128-woe6knpv	53	46	binding	binding	NN
cord-301128-woe6knpv	53	47	site	site	NN
cord-301128-woe6knpv	53	48	of	of	IN
cord-301128-woe6knpv	53	49	the	the	DT
cord-301128-woe6knpv	53	50	sequencespecific	sequencespecific	NNP
cord-301128-woe6knpv	53	51	DNA	dna	NN
cord-301128-woe6knpv	53	52	-	-	HYPH
cord-301128-woe6knpv	53	53	binding	bind	VBG
cord-301128-woe6knpv	53	54	protein	protein	NN
cord-301128-woe6knpv	53	55	LacI	LacI	NNP
cord-301128-woe6knpv	53	56	at	at	IN
cord-301128-woe6knpv	53	57	two	two	CD
cord-301128-woe6knpv	53	58	different	different	JJ
cord-301128-woe6knpv	53	59	locations	location	NNS
cord-301128-woe6knpv	53	60	,	,	,
cord-301128-woe6knpv	53	61	such	such	JJ
cord-301128-woe6knpv	53	62	that	that	IN
cord-301128-woe6knpv	53	63	the	the	DT
cord-301128-woe6knpv	53	64	plasmid	plasmid	NN
cord-301128-woe6knpv	53	65	was	be	VBD
cord-301128-woe6knpv	53	66	divided	divide	VBN
cord-301128-woe6knpv	53	67	into	into	IN
cord-301128-woe6knpv	53	68	two	two	CD
cord-301128-woe6knpv	53	69	stable	stable	JJ
cord-301128-woe6knpv	53	70	loops	loop	NNS
cord-301128-woe6knpv	53	71	of	of	IN
cord-301128-woe6knpv	53	72	respective	respective	JJ
cord-301128-woe6knpv	53	73	length	length	NN
cord-301128-woe6knpv	53	74	2900	2900	CD
cord-301128-woe6knpv	53	75	bp	bp	NNP
cord-301128-woe6knpv	53	76	and	and	CC
cord-301128-woe6knpv	53	77	1200	1200	CD
cord-301128-woe6knpv	53	78	bp	bp	NNP
cord-301128-woe6knpv	53	79	upon	upon	IN
cord-301128-woe6knpv	53	80	binding	bind	VBG
cord-301128-woe6knpv	53	81	of	of	IN
cord-301128-woe6knpv	53	82	LacI.	LacI.	NNP
cord-301128-woe6knpv	54	1	The	the	DT
cord-301128-woe6knpv	54	2	1200	1200	CD
cord-301128-woe6knpv	54	3	bp	bp	NNP
cord-301128-woe6knpv	54	4	region	region	NN
cord-301128-woe6knpv	54	5	moreover	moreover	RB
cord-301128-woe6knpv	54	6	contained	contain	VBD
cord-301128-woe6knpv	54	7	the	the	DT
cord-301128-woe6knpv	54	8	recognition	recognition	NN
cord-301128-woe6knpv	54	9	site	site	NN
cord-301128-woe6knpv	54	10	for	for	IN
cord-301128-woe6knpv	54	11	one	one	CD
cord-301128-woe6knpv	54	12	nicking	nicking	NN
cord-301128-woe6knpv	54	13	enzyme	enzyme	NN
cord-301128-woe6knpv	54	14	(	(	-LRB-
cord-301128-woe6knpv	54	15	Nt	nt	UH
cord-301128-woe6knpv	54	16	.	.	.
cord-301128-woe6knpv	54	17	BbvC1	BbvC1	NNP
cord-301128-woe6knpv	54	18	)	)	-RRB-
cord-301128-woe6knpv	54	19	and	and	CC
cord-301128-woe6knpv	54	20	the	the	DT
cord-301128-woe6knpv	54	21	2900	2900	CD
cord-301128-woe6knpv	54	22	bp	bp	NNP
cord-301128-woe6knpv	54	23	region	region	NN
cord-301128-woe6knpv	54	24	the	the	DT
cord-301128-woe6knpv	54	25	recognition	recognition	NN
cord-301128-woe6knpv	54	26	site	site	NN
cord-301128-woe6knpv	54	27	for	for	IN
cord-301128-woe6knpv	54	28	a	a	DT
cord-301128-woe6knpv	54	29	second	second	JJ
cord-301128-woe6knpv	54	30	nicking	nicking	NN
cord-301128-woe6knpv	54	31	enzyme	enzyme	NN
cord-301128-woe6knpv	54	32	(	(	-LRB-
cord-301128-woe6knpv	54	33	Nb	Nb	NNP
cord-301128-woe6knpv	54	34	.	.	.
cord-301128-woe6knpv	54	35	BtsI	BtsI	NNP
cord-301128-woe6knpv	54	36	)	)	-RRB-
cord-301128-woe6knpv	54	37	.	.	.
cord-301128-woe6knpv	55	1	In	in	IN
cord-301128-woe6knpv	55	2	the	the	DT
cord-301128-woe6knpv	55	3	absence	absence	NN
cord-301128-woe6knpv	55	4	of	of	IN
cord-301128-woe6knpv	55	5	LacI	LacI	NNP
cord-301128-woe6knpv	55	6	,	,	,
cord-301128-woe6knpv	55	7	addition	addition	NN
cord-301128-woe6knpv	55	8	of	of	IN
cord-301128-woe6knpv	55	9	Nt	Nt	NNP
cord-301128-woe6knpv	55	10	.	.	.
cord-301128-woe6knpv	56	1	BbvC1	BbvC1	NNP
cord-301128-woe6knpv	56	2	alone	alone	RB
cord-301128-woe6knpv	56	3	or	or	CC
cord-301128-woe6knpv	56	4	Nb	Nb	NNP
cord-301128-woe6knpv	56	5	.	.	.
cord-301128-woe6knpv	57	1	BtsI	BtsI	NNP
cord-301128-woe6knpv	57	2	alone	alone	RB
cord-301128-woe6knpv	57	3	was	be	VBD
cord-301128-woe6knpv	57	4	sufficient	sufficient	JJ
cord-301128-woe6knpv	57	5	to	to	TO
cord-301128-woe6knpv	57	6	release	release	VB
cord-301128-woe6knpv	57	7	the	the	DT
cord-301128-woe6knpv	57	8	full	full	JJ
cord-301128-woe6knpv	57	9	torsional	torsional	JJ
cord-301128-woe6knpv	57	10	stress	stress	NN
cord-301128-woe6knpv	57	11	of	of	IN
cord-301128-woe6knpv	57	12	the	the	DT
cord-301128-woe6knpv	57	13	plasmid	plasmid	NN
cord-301128-woe6knpv	57	14	.	.	.
cord-301128-woe6knpv	58	1	In	in	IN
cord-301128-woe6knpv	58	2	contrast	contrast	NN
cord-301128-woe6knpv	58	3	,	,	,
cord-301128-woe6knpv	58	4	in	in	IN
cord-301128-woe6knpv	58	5	the	the	DT
cord-301128-woe6knpv	58	6	presence	presence	NN
cord-301128-woe6knpv	58	7	of	of	IN
cord-301128-woe6knpv	58	8	LacI	LacI	NNP
cord-301128-woe6knpv	58	9	,	,	,
cord-301128-woe6knpv	58	10	addition	addition	NN
cord-301128-woe6knpv	58	11	of	of	IN
cord-301128-woe6knpv	58	12	Nt	Nt	NNP
cord-301128-woe6knpv	58	13	.	.	.
cord-301128-woe6knpv	59	1	BbvC1	BbvC1	NNP
cord-301128-woe6knpv	59	2	alone	alone	RB
cord-301128-woe6knpv	59	3	removed	remove	VBD
cord-301128-woe6knpv	59	4	only	only	RB
cord-301128-woe6knpv	59	5	the	the	DT
cord-301128-woe6knpv	59	6	7	7	CD
cord-301128-woe6knpv	59	7	negative	negative	JJ
cord-301128-woe6knpv	59	8	supercoils	supercoil	NNS
cord-301128-woe6knpv	59	9	of	of	IN
cord-301128-woe6knpv	59	10	the	the	DT
cord-301128-woe6knpv	59	11	1200	1200	CD
cord-301128-woe6knpv	59	12	bp	bp	NNP
cord-301128-woe6knpv	59	13	region	region	NN
cord-301128-woe6knpv	59	14	,	,	,
cord-301128-woe6knpv	59	15	while	while	IN
cord-301128-woe6knpv	59	16	addition	addition	NN
cord-301128-woe6knpv	59	17	of	of	IN
cord-301128-woe6knpv	59	18	Nb	Nb	NNP
cord-301128-woe6knpv	59	19	.	.	.
cord-301128-woe6knpv	60	1	BtsI	BtsI	NNP
cord-301128-woe6knpv	60	2	alone	alone	RB
cord-301128-woe6knpv	60	3	removed	remove	VBD
cord-301128-woe6knpv	60	4	only	only	RB
cord-301128-woe6knpv	60	5	the	the	DT
cord-301128-woe6knpv	60	6	17	17	CD
cord-301128-woe6knpv	60	7	negative	negative	JJ
cord-301128-woe6knpv	60	8	supercoils	supercoil	NNS
cord-301128-woe6knpv	60	9	of	of	IN
cord-301128-woe6knpv	60	10	the	the	DT
cord-301128-woe6knpv	60	11	2900	2900	CD
cord-301128-woe6knpv	60	12	bp	bp	NNP
cord-301128-woe6knpv	60	13	region	region	NN
cord-301128-woe6knpv	60	14	(	(	-LRB-
cord-301128-woe6knpv	60	15	15	15	CD
cord-301128-woe6knpv	60	16	)	)	-RRB-
cord-301128-woe6knpv	60	17	.	.	.
cord-301128-woe6knpv	61	1	Simultaneous	simultaneous	JJ
cord-301128-woe6knpv	61	2	addition	addition	NN
cord-301128-woe6knpv	61	3	of	of	IN
cord-301128-woe6knpv	61	4	both	both	DT
cord-301128-woe6knpv	61	5	enzymes	enzyme	NNS
cord-301128-woe6knpv	61	6	was	be	VBD
cord-301128-woe6knpv	61	7	required	require	VBN
cord-301128-woe6knpv	61	8	to	to	TO
cord-301128-woe6knpv	61	9	relax	relax	VB
cord-301128-woe6knpv	61	10	the	the	DT
cord-301128-woe6knpv	61	11	full	full	JJ
cord-301128-woe6knpv	61	12	plasmid	plasmid	NN
cord-301128-woe6knpv	61	13	(	(	-LRB-
cord-301128-woe6knpv	61	14	15	15	CD
cord-301128-woe6knpv	61	15	)	)	-RRB-
cord-301128-woe6knpv	61	16	.	.	.
cord-301128-woe6knpv	62	1	This	this	DT
cord-301128-woe6knpv	62	2	experiment	experiment	NN
cord-301128-woe6knpv	62	3	demonstrates	demonstrate	VBZ
cord-301128-woe6knpv	62	4	very	very	RB
cord-301128-woe6knpv	62	5	clearly	clearly	RB
cord-301128-woe6knpv	62	6	that	that	IN
cord-301128-woe6knpv	62	7	pairs	pair	NNS
cord-301128-woe6knpv	62	8	of	of	IN
cord-301128-woe6knpv	62	9	LacI	LacI	NNP
cord-301128-woe6knpv	62	10	bridges	bridge	NNS
cord-301128-woe6knpv	62	11	block	block	VBP
cord-301128-woe6knpv	62	12	the	the	DT
cord-301128-woe6knpv	62	13	diffusion	diffusion	NN
cord-301128-woe6knpv	62	14	of	of	IN
cord-301128-woe6knpv	62	15	torsional	torsional	JJ
cord-301128-woe6knpv	62	16	stress	stress	NN
cord-301128-woe6knpv	62	17	and	and	CC
cord-301128-woe6knpv	62	18	divide	divide	VB
cord-301128-woe6knpv	62	19	the	the	DT
cord-301128-woe6knpv	62	20	plasmids	plasmid	NNS
cord-301128-woe6knpv	62	21	into	into	IN
cord-301128-woe6knpv	62	22	two	two	CD
cord-301128-woe6knpv	62	23	independent	independent	JJ
cord-301128-woe6knpv	62	24	topological	topological	JJ
cord-301128-woe6knpv	62	25	domains	domain	NNS
cord-301128-woe6knpv	62	26	.	.	.
cord-301128-woe6knpv	63	1	We	-PRON-	PRP
cord-301128-woe6knpv	63	2	report	report	VBP
cord-301128-woe6knpv	63	3	below	below	IN
cord-301128-woe6knpv	63	4	on	on	IN
cord-301128-woe6knpv	63	5	our	-PRON-	PRP$
cord-301128-woe6knpv	63	6	efforts	effort	NNS
cord-301128-woe6knpv	63	7	to	to	TO
cord-301128-woe6knpv	63	8	determine	determine	VB
cord-301128-woe6knpv	63	9	the	the	DT
cord-301128-woe6knpv	63	10	minimal	minimal	JJ
cord-301128-woe6knpv	63	11	set	set	NN
cord-301128-woe6knpv	63	12	of	of	IN
cord-301128-woe6knpv	63	13	mandatory	mandatory	JJ
cord-301128-woe6knpv	63	14	properties	property	NNS
cord-301128-woe6knpv	63	15	that	that	WDT
cord-301128-woe6knpv	63	16	allow	allow	VBP
cord-301128-woe6knpv	63	17	molecular	molecular	JJ
cord-301128-woe6knpv	63	18	bridges	bridge	NNS
cord-301128-woe6knpv	63	19	to	to	TO
cord-301128-woe6knpv	63	20	act	act	VB
cord-301128-woe6knpv	63	21	as	as	IN
cord-301128-woe6knpv	63	22	topological	topological	JJ
cord-301128-woe6knpv	63	23	barriers	barrier	NNS
cord-301128-woe6knpv	63	24	and	and	CC
cord-301128-woe6knpv	63	25	block	block	VB
cord-301128-woe6knpv	63	26	the	the	DT
cord-301128-woe6knpv	63	27	diffusion	diffusion	NN
cord-301128-woe6knpv	63	28	of	of	IN
cord-301128-woe6knpv	63	29	torsional	torsional	JJ
cord-301128-woe6knpv	63	30	stress	stress	NN
cord-301128-woe6knpv	63	31	in	in	IN
cord-301128-woe6knpv	63	32	out	out	IN
cord-301128-woe6knpv	63	33	-	-	HYPH
cord-301128-woe6knpv	63	34	of	of	IN
cord-301128-woe6knpv	63	35	-	-	HYPH
cord-301128-woe6knpv	63	36	equilibrium	equilibrium	NN
cord-301128-woe6knpv	63	37	supercoiled	supercoile	VBN
cord-301128-woe6knpv	63	38	chains	chain	NNS
cord-301128-woe6knpv	63	39	.	.	.
cord-301128-woe6knpv	64	1	Preparation	preparation	NN
cord-301128-woe6knpv	64	2	of	of	IN
cord-301128-woe6knpv	64	3	torsionally	torsionally	RB
cord-301128-woe6knpv	64	4	out	out	IN
cord-301128-woe6knpv	64	5	-	-	HYPH
cord-301128-woe6knpv	64	6	of	of	IN
cord-301128-woe6knpv	64	7	-	-	HYPH
cord-301128-woe6knpv	64	8	equilibrium	equilibrium	NN
cord-301128-woe6knpv	64	9	circular	circular	JJ
cord-301128-woe6knpv	64	10	chains	chain	NNS
cord-301128-woe6knpv	64	11	.	.	.
cord-301128-woe6knpv	65	1	,	,	,
cord-301128-woe6knpv	65	2	which	which	WDT
cord-301128-woe6knpv	65	3	were	be	VBD
cord-301128-woe6knpv	65	4	chosen	choose	VBN
cord-301128-woe6knpv	65	5	so	so	IN
cord-301128-woe6knpv	65	6	that	that	IN
cord-301128-woe6knpv	65	7	the	the	DT
cord-301128-woe6knpv	65	8	distance	distance	NN
cord-301128-woe6knpv	65	9	between	between	IN
cord-301128-woe6knpv	65	10	their	-PRON-	PRP$
cord-301128-woe6knpv	65	11	centers	center	NNS
cord-301128-woe6knpv	65	12	is	be	VBZ
cord-301128-woe6knpv	65	13	smaller	small	JJR
cord-301128-woe6knpv	65	14	than	than	IN
cord-301128-woe6knpv	65	15	10	10	CD
cord-301128-woe6knpv	65	16	nm	nm	NN
cord-301128-woe6knpv	65	17	.	.	.
cord-301128-woe6knpv	66	1	This	this	DT
cord-301128-woe6knpv	66	2	step	step	NN
cord-301128-woe6knpv	66	3	is	be	VBZ
cord-301128-woe6knpv	66	4	illustrated	illustrate	VBN
cord-301128-woe6knpv	66	5	in	in	IN
cord-301128-woe6knpv	66	6	Fig	Fig	NNP
cord-301128-woe6knpv	66	7	.	.	.
cord-301128-woe6knpv	66	8	1	1	CD
cord-301128-woe6knpv	66	9	(	(	-LRB-
cord-301128-woe6knpv	66	10	a	a	LS
cord-301128-woe6knpv	66	11	)	)	-RRB-
cord-301128-woe6knpv	66	12	,	,	,
cord-301128-woe6knpv	66	13	which	which	WDT
cord-301128-woe6knpv	66	14	shows	show	VBZ
cord-301128-woe6knpv	66	15	an	an	DT
cord-301128-woe6knpv	66	16	equilibrated	equilibrated	JJ
cord-301128-woe6knpv	66	17	chain	chain	NN
cord-301128-woe6knpv	66	18	with	with	IN
cord-301128-woe6knpv	66	19	 	 	_SP
cord-301128-woe6knpv	66	20	where	where	WRB
cord-301128-woe6knpv	66	21	12	12	CD
cord-301128-woe6knpv	66	22	r	r	NNP
cord-301128-woe6knpv	66	23	W	W	NNP
cord-301128-woe6knpv	66	24	quantifies	quantify	VBZ
cord-301128-woe6knpv	66	25	the	the	DT
cord-301128-woe6knpv	66	26	winding	winding	NN
cord-301128-woe6knpv	66	27	of	of	IN
cord-301128-woe6knpv	66	28	one	one	CD
cord-301128-woe6knpv	66	29	moiety	moiety	NN
cord-301128-woe6knpv	66	30	of	of	IN
cord-301128-woe6knpv	66	31	the	the	DT
cord-301128-woe6knpv	66	32	chain	chain	NN
cord-301128-woe6knpv	66	33	around	around	IN
cord-301128-woe6knpv	66	34	the	the	DT
cord-301128-woe6knpv	66	35	other	other	JJ
cord-301128-woe6knpv	66	36	one	one	NN
cord-301128-woe6knpv	66	37	,	,	,
cord-301128-woe6knpv	66	38	that	that	RB
cord-301128-woe6knpv	66	39	is	is	RB
cord-301128-woe6knpv	66	40	,	,	,
cord-301128-woe6knpv	66	41	loosely	loosely	RB
cord-301128-woe6knpv	66	42	speaking	speak	VBG
cord-301128-woe6knpv	66	43	,	,	,
cord-301128-woe6knpv	66	44	their	-PRON-	PRP$
cord-301128-woe6knpv	66	45	intrication	intrication	NN
cord-301128-woe6knpv	66	46	.	.	.
cord-301128-woe6knpv	67	1	The	the	DT
cord-301128-woe6knpv	67	2	out	out	JJ
cord-301128-woe6knpv	67	3	-	-	HYPH
cord-301128-woe6knpv	67	4	of	of	IN
cord-301128-woe6knpv	67	5	-	-	HYPH
cord-301128-woe6knpv	67	6	equilibrium	equilibrium	NN
cord-301128-woe6knpv	67	7	chains	chain	NNS
cord-301128-woe6knpv	67	8	prepared	prepare	VBN
cord-301128-woe6knpv	67	9	as	as	IN
cord-301128-woe6knpv	67	10	described	describe	VBN
cord-301128-woe6knpv	67	11	above	above	IN
cord-301128-woe6knpv	67	12	The	the	DT
cord-301128-woe6knpv	67	13	main	main	JJ
cord-301128-woe6knpv	67	14	purpose	purpose	NN
cord-301128-woe6knpv	67	15	of	of	IN
cord-301128-woe6knpv	67	16	this	this	DT
cord-301128-woe6knpv	67	17	work	work	NN
cord-301128-woe6knpv	67	18	is	be	VBZ
cord-301128-woe6knpv	67	19	to	to	TO
cord-301128-woe6knpv	67	20	understand	understand	VB
cord-301128-woe6knpv	67	21	how	how	WRB
cord-301128-woe6knpv	67	22	DNA	dna	NN
cord-301128-woe6knpv	67	23	-	-	HYPH
cord-301128-woe6knpv	67	24	bridging	bridge	VBG
cord-301128-woe6knpv	67	25	proteins	protein	NNS
cord-301128-woe6knpv	67	26	like	like	IN
cord-301128-woe6knpv	67	27	LacI	LacI	NNP
cord-301128-woe6knpv	67	28	(	(	-LRB-
cord-301128-woe6knpv	67	29	15	15	CD
cord-301128-woe6knpv	67	30	,	,	,
cord-301128-woe6knpv	67	31	23	23	CD
cord-301128-woe6knpv	67	32	,	,	,
cord-301128-woe6knpv	67	33	24	24	CD
cord-301128-woe6knpv	67	34	)	)	-RRB-
cord-301128-woe6knpv	67	35	can	can	MD
cord-301128-woe6knpv	67	36	maintain	maintain	VB
cord-301128-woe6knpv	67	37	such	such	PDT
cord-301128-woe6knpv	67	38	an	an	DT
cord-301128-woe6knpv	67	39	unbalance	unbalance	NN
cord-301128-woe6knpv	67	40	when	when	WRB
cord-301128-woe6knpv	67	41	the	the	DT
cord-301128-woe6knpv	67	42	whole	whole	JJ
cord-301128-woe6knpv	67	43	chain	chain	NN
cord-301128-woe6knpv	67	44	is	be	VBZ
cord-301128-woe6knpv	67	45	relaxed	relaxed	JJ
cord-301128-woe6knpv	67	46	.	.	.
cord-301128-woe6knpv	68	1	Since	since	IN
cord-301128-woe6knpv	68	2	DNAbridging	dnabridging	NN
cord-301128-woe6knpv	68	3	proteins	protein	NNS
cord-301128-woe6knpv	68	4	form	form	VBP
cord-301128-woe6knpv	68	5	DNA	dna	NN
cord-301128-woe6knpv	68	6	loops	loop	NNS
cord-301128-woe6knpv	68	7	by	by	IN
cord-301128-woe6knpv	68	8	dynamically	dynamically	RB
cord-301128-woe6knpv	68	9	cross	cross	NN
cord-301128-woe6knpv	68	10	-	-	JJ
cord-301128-woe6knpv	68	11	linking	link	VBG
cord-301128-woe6knpv	68	12	widely	widely	RB
cord-301128-woe6knpv	68	13	separated	separate	VBN
cord-301128-woe6knpv	68	14	DNA	dna	NN
cord-301128-woe6knpv	68	15	sites	site	NNS
cord-301128-woe6knpv	68	16	,	,	,
cord-301128-woe6knpv	68	17	the	the	DT
cord-301128-woe6knpv	68	18	question	question	NN
cord-301128-woe6knpv	68	19	amounts	amount	VBZ
cord-301128-woe6knpv	68	20	here	here	RB
cord-301128-woe6knpv	68	21	to	to	TO
cord-301128-woe6knpv	68	22	determine	determine	VB
cord-301128-woe6knpv	68	23	the	the	DT
cord-301128-woe6knpv	68	24	constraints	constraint	NNS
cord-301128-woe6knpv	68	25	that	that	WDT
cord-301128-woe6knpv	68	26	must	must	MD
cord-301128-woe6knpv	68	27	be	be	VB
cord-301128-woe6knpv	68	28	imposed	impose	VBN
cord-301128-woe6knpv	68	29	to	to	IN
cord-301128-woe6knpv	68	30	beads	bead	NNS
cord-301128-woe6knpv	68	31	α	α	NN
cord-301128-woe6knpv	68	32	and	and	CC
cord-301128-woe6knpv	68	33	β	β	NN
cord-301128-woe6knpv	68	34	J	J	NNP
cord-301128-woe6knpv	68	35	o	o	NN
cord-301128-woe6knpv	68	36	u	u	NN
cord-301128-woe6knpv	68	37	r	r	NN
cord-301128-woe6knpv	68	38	n	n	NN
cord-301128-woe6knpv	68	39	a	a	DT
cord-301128-woe6knpv	68	40	l	l	NN
cord-301128-woe6knpv	68	41	P	p	NN
cord-301128-woe6knpv	68	42	r	r	NN
cord-301128-woe6knpv	68	43	e	e	NN
cord-301128-woe6knpv	69	1	-p	-p	NNP
cord-301128-woe6knpv	69	2	r	r	NN
cord-301128-woe6knpv	69	3	o	o	NN
cord-301128-woe6knpv	69	4	o	o	NN
cord-301128-woe6knpv	69	5	f	f	NN
cord-301128-woe6knpv	70	1	to	to	TO
cord-301128-woe6knpv	70	2	divide	divide	VB
cord-301128-woe6knpv	70	3	the	the	DT
cord-301128-woe6knpv	70	4	circular	circular	JJ
cord-301128-woe6knpv	70	5	DNA	dna	NN
cord-301128-woe6knpv	70	6	chain	chain	NN
cord-301128-woe6knpv	70	7	into	into	IN
cord-301128-woe6knpv	70	8	two	two	CD
cord-301128-woe6knpv	70	9	topologically	topologically	RB
cord-301128-woe6knpv	70	10	independent	independent	JJ
cord-301128-woe6knpv	70	11	loops	loop	NNS
cord-301128-woe6knpv	70	12	.	.	.
cord-301128-woe6knpv	71	1	Note	note	VB
cord-301128-woe6knpv	71	2	that	that	IN
cord-301128-woe6knpv	71	3	DNAbridging	dnabridging	NN
cord-301128-woe6knpv	71	4	proteins	protein	NNS
cord-301128-woe6knpv	71	5	are	be	VBP
cord-301128-woe6knpv	71	6	not	not	RB
cord-301128-woe6knpv	71	7	introduced	introduce	VBN
cord-301128-woe6knpv	71	8	explicitly	explicitly	RB
cord-301128-woe6knpv	71	9	in	in	IN
cord-301128-woe6knpv	71	10	the	the	DT
cord-301128-woe6knpv	71	11	model	model	NN
cord-301128-woe6knpv	71	12	:	:	:
cord-301128-woe6knpv	71	13	Rather	rather	RB
cord-301128-woe6knpv	71	14	,	,	,
cord-301128-woe6knpv	71	15	constraints	constraint	NNS
cord-301128-woe6knpv	71	16	on	on	IN
cord-301128-woe6knpv	71	17	beads	bead	NNS
cord-301128-woe6knpv	71	18	α	α	NN
cord-301128-woe6knpv	71	19	and	and	CC
cord-301128-woe6knpv	71	20	β	β	NN
cord-301128-woe6knpv	71	21	are	be	VBP
cord-301128-woe6knpv	71	22	meant	mean	VBN
cord-301128-woe6knpv	71	23	to	to	TO
cord-301128-woe6knpv	71	24	model	model	VB
cord-301128-woe6knpv	71	25	the	the	DT
cord-301128-woe6knpv	71	26	mechanisms	mechanism	NNS
cord-301128-woe6knpv	71	27	that	that	WDT
cord-301128-woe6knpv	71	28	allow	allow	VBP
cord-301128-woe6knpv	71	29	the	the	DT
cord-301128-woe6knpv	71	30	proteins	protein	NNS
cord-301128-woe6knpv	71	31	to	to	TO
cord-301128-woe6knpv	71	32	act	act	VB
cord-301128-woe6knpv	71	33	as	as	IN
cord-301128-woe6knpv	71	34	topological	topological	JJ
cord-301128-woe6knpv	71	35	barriers	barrier	NNS
cord-301128-woe6knpv	71	36	.	.	.
cord-301128-woe6knpv	72	1	Twist	twist	NN
cord-301128-woe6knpv	72	2	equilibrates	equilibrate	VBZ
cord-301128-woe6knpv	72	3	much	much	RB
cord-301128-woe6knpv	72	4	more	more	RBR
cord-301128-woe6knpv	72	5	rapidly	rapidly	RB
cord-301128-woe6knpv	72	6	than	than	IN
cord-301128-woe6knpv	72	7	writhe	writhe	VB
cord-301128-woe6knpv	72	8	.	.	.
cord-301128-woe6knpv	73	1	In	in	IN
cord-301128-woe6knpv	73	2	order	order	NN
cord-301128-woe6knpv	73	3	to	to	TO
cord-301128-woe6knpv	73	4	understand	understand	VB
cord-301128-woe6knpv	73	5	in	in	IN
cord-301128-woe6knpv	73	6	more	more	JJR
cord-301128-woe6knpv	73	7	detail	detail	NN
cord-301128-woe6knpv	73	8	how	how	WRB
cord-301128-woe6knpv	73	9	the	the	DT
cord-301128-woe6knpv	73	10	diffusion	diffusion	NN
cord-301128-woe6knpv	73	11	of	of	IN
cord-301128-woe6knpv	73	12	torsional	torsional	JJ
cord-301128-woe6knpv	73	13	stress	stress	NN
cord-301128-woe6knpv	73	14	proceeds	proceed	NNS
cord-301128-woe6knpv	73	15	,	,	,
cord-301128-woe6knpv	73	16	the	the	DT
cord-301128-woe6knpv	73	17	out	out	JJ
cord-301128-woe6knpv	73	18	-	-	HYPH
cord-301128-woe6knpv	73	19	of	of	IN
cord-301128-woe6knpv	73	20	-	-	HYPH
cord-301128-woe6knpv	73	21	equilibrium	equilibrium	NN
cord-301128-woe6knpv	73	22	circular	circular	JJ
cord-301128-woe6knpv	73	23	chains	chain	NNS
cord-301128-woe6knpv	73	24	prepared	prepare	VBN
cord-301128-woe6knpv	73	25	as	as	IN
cord-301128-woe6knpv	73	26	described	describe	VBN
cord-301128-woe6knpv	73	27	above	above	RB
cord-301128-woe6knpv	73	28	were	be	VBD
cord-301128-woe6knpv	73	29	allowed	allow	VBN
cord-301128-woe6knpv	73	30	to	to	TO
cord-301128-woe6knpv	73	31	relax	relax	VB
cord-301128-woe6knpv	73	32	without	without	IN
cord-301128-woe6knpv	73	33	constraint	constraint	NN
cord-301128-woe6knpv	73	34	and	and	CC
cord-301128-woe6knpv	73	35	all	all	DT
cord-301128-woe6knpv	73	36	relevant	relevant	JJ
cord-301128-woe6knpv	73	37	quantities	quantity	NNS
cord-301128-woe6knpv	73	38	were	be	VBD
cord-301128-woe6knpv	73	39	monitored	monitor	VBN
cord-301128-woe6knpv	73	40	.	.	.
cord-301128-woe6knpv	74	1	From	from	IN
cord-301128-woe6knpv	74	2	a	a	DT
cord-301128-woe6knpv	74	3	practical	practical	JJ
cord-301128-woe6knpv	74	4	point	point	NN
cord-301128-woe6knpv	74	5	of	of	IN
cord-301128-woe6knpv	74	6	view	view	NN
cord-301128-woe6knpv	74	7	,	,	,
cord-301128-woe6knpv	74	8	four	four	CD
cord-301128-woe6knpv	74	9	different	different	JJ
cord-301128-woe6knpv	74	10	initial	initial	JJ
cord-301128-woe6knpv	74	11	out	out	IN
cord-301128-woe6knpv	74	12	-	-	HYPH
cord-301128-woe6knpv	74	13	of	of	IN
cord-301128-woe6knpv	74	14	-	-	HYPH
cord-301128-woe6knpv	74	15	equilibrium	equilibrium	NN
cord-301128-woe6knpv	74	16	conformations	conformation	NNS
cord-301128-woe6knpv	74	17	were	be	VBD
cord-301128-woe6knpv	74	18	prepared	prepare	VBN
cord-301128-woe6knpv	74	19	for	for	IN
cord-301128-woe6knpv	74	20	each	each	DT
cord-301128-woe6knpv	74	21	value	value	NN
cord-301128-woe6knpv	74	22	of	of	IN
cord-301128-woe6knpv	74	23	0	0	CD
cord-301128-woe6knpv	74	24	k	k	NNP
cord-301128-woe6knpv	74	25	L	L	NNP
cord-301128-woe6knpv	74	26	∆	∆	NNP
cord-301128-woe6knpv	74	27	and	and	CC
cord-301128-woe6knpv	74	28	100	100	CD
cord-301128-woe6knpv	74	29	different	different	JJ
cord-301128-woe6knpv	74	30	relaxation	relaxation	NN
cord-301128-woe6knpv	74	31	trajectories	trajectory	NNS
cord-301128-woe6knpv	74	32	were	be	VBD
cord-301128-woe6knpv	74	33	integrated	integrate	VBN
cord-301128-woe6knpv	74	34	for	for	IN
cord-301128-woe6knpv	74	35	1	1	CD
cord-301128-woe6knpv	74	36	ms	m	NNS
cord-301128-woe6knpv	74	37	for	for	IN
cord-301128-woe6knpv	74	38	each	each	DT
cord-301128-woe6knpv	74	39	initial	initial	JJ
cord-301128-woe6knpv	74	40	conformation	conformation	NN
cord-301128-woe6knpv	74	41	.	.	.
cord-301128-woe6knpv	74	42	,	,	,
cord-301128-woe6knpv	74	43	and	and	CC
cord-301128-woe6knpv	74	44	r	r	NNP
cord-301128-woe6knpv	74	45	j	j	NNP
cord-301128-woe6knpv	74	46	W	W	NNP
cord-301128-woe6knpv	74	47	(	(	-LRB-
cord-301128-woe6knpv	74	48	1	1	CD
cord-301128-woe6knpv	74	49	j	j	NNP
cord-301128-woe6knpv	74	50	=	=	NNP
cord-301128-woe6knpv	74	51	,	,	,
cord-301128-woe6knpv	74	52	2	2	CD
cord-301128-woe6knpv	74	53	)	)	-RRB-
cord-301128-woe6knpv	74	54	was	be	VBD
cord-301128-woe6knpv	74	55	then	then	RB
cord-301128-woe6knpv	74	56	averaged	average	VBN
cord-301128-woe6knpv	74	57	over	over	IN
cord-301128-woe6knpv	74	58	these	these	DT
cord-301128-woe6knpv	74	59	100	100	CD
cord-301128-woe6knpv	74	60	trajectories	trajectory	NNS
cord-301128-woe6knpv	74	61	.	.	.
cord-301128-woe6knpv	75	1	In	in	IN
cord-301128-woe6knpv	75	2	the	the	DT
cord-301128-woe6knpv	75	3	absence	absence	NN
cord-301128-woe6knpv	75	4	of	of	IN
cord-301128-woe6knpv	75	5	any	any	DT
cord-301128-woe6knpv	75	6	constraint	constraint	NN
cord-301128-woe6knpv	75	7	on	on	IN
cord-301128-woe6knpv	75	8	beads	bead	NNS
cord-301128-woe6knpv	75	9	α	α	NN
cord-301128-woe6knpv	75	10	and	and	CC
cord-301128-woe6knpv	75	11	β	β	NN
cord-301128-woe6knpv	75	12	,	,	,
cord-301128-woe6knpv	75	13	all	all	DT
cord-301128-woe6knpv	75	14	conformations	conformation	NNS
cord-301128-woe6knpv	75	15	obtained	obtain	VBN
cord-301128-woe6knpv	75	16	at	at	IN
cord-301128-woe6knpv	75	17	the	the	DT
cord-301128-woe6knpv	75	18	end	end	NN
cord-301128-woe6knpv	75	19	of	of	IN
cord-301128-woe6knpv	75	20	the	the	DT
cord-301128-woe6knpv	75	21	1	1	CD
cord-301128-woe6knpv	75	22	ms	ms	NNP
cord-301128-woe6knpv	75	23	integration	integration	NN
cord-301128-woe6knpv	75	24	time	time	NN
cord-301128-woe6knpv	75	25	satisfy	satisfy	VB
cord-301128-woe6knpv	75	26	 	 	_SP
cord-301128-woe6knpv	75	27	where	where	WRB
cord-301128-woe6knpv	75	28	w	w	NNP
cord-301128-woe6knpv	75	29	 	 	_SP
cord-301128-woe6knpv	76	1	Based	base	VBN
cord-301128-woe6knpv	76	2	on	on	IN
cord-301128-woe6knpv	76	3	recent	recent	JJ
cord-301128-woe6knpv	76	4	experimental	experimental	JJ
cord-301128-woe6knpv	76	5	results	result	NNS
cord-301128-woe6knpv	76	6	(	(	-LRB-
cord-301128-woe6knpv	76	7	12	12	CD
cord-301128-woe6knpv	76	8	)	)	-RRB-
cord-301128-woe6knpv	76	9	(	(	-LRB-
cord-301128-woe6knpv	76	10	13	13	CD
cord-301128-woe6knpv	76	11	)	)	-RRB-
cord-301128-woe6knpv	76	12	(	(	-LRB-
cord-301128-woe6knpv	76	13	14	14	CD
cord-301128-woe6knpv	76	14	)	)	-RRB-
cord-301128-woe6knpv	76	15	(	(	-LRB-
cord-301128-woe6knpv	76	16	15	15	CD
cord-301128-woe6knpv	76	17	)	)	-RRB-
cord-301128-woe6knpv	76	18	(	(	-LRB-
cord-301128-woe6knpv	76	19	16	16	CD
cord-301128-woe6knpv	76	20	)	)	-RRB-
cord-301128-woe6knpv	76	21	,	,	,
cord-301128-woe6knpv	76	22	one	one	PRP
cord-301128-woe6knpv	76	23	may	may	MD
cord-301128-woe6knpv	76	24	wonder	wonder	VB
cord-301128-woe6knpv	76	25	whether	whether	IN
cord-301128-woe6knpv	76	26	DNA	dna	NN
cord-301128-woe6knpv	76	27	loops	loop	NNS
cord-301128-woe6knpv	76	28	are	be	VBP
cord-301128-woe6knpv	76	29	ipso	ipso	FW
cord-301128-woe6knpv	76	30	facto	facto	FW
cord-301128-woe6knpv	76	31	independent	independent	JJ
cord-301128-woe6knpv	76	32	topological	topological	JJ
cord-301128-woe6knpv	76	33	domains	domain	NNS
cord-301128-woe6knpv	76	34	,	,	,
cord-301128-woe6knpv	76	35	or	or	CC
cord-301128-woe6knpv	76	36	whether	whether	IN
cord-301128-woe6knpv	76	37	some	some	DT
cord-301128-woe6knpv	76	38	additional	additional	JJ
cord-301128-woe6knpv	76	39	,	,	,
cord-301128-woe6knpv	76	40	more	more	RBR
cord-301128-woe6knpv	76	41	subtle	subtle	JJ
cord-301128-woe6knpv	76	42	properties	property	NNS
cord-301128-woe6knpv	76	43	of	of	IN
cord-301128-woe6knpv	76	44	DNA	dna	NN
cord-301128-woe6knpv	76	45	-	-	HYPH
cord-301128-woe6knpv	76	46	bridging	bridge	VBG
cord-301128-woe6knpv	76	47	proteins	protein	NNS
cord-301128-woe6knpv	76	48	are	be	VBP
cord-301128-woe6knpv	76	49	required	require	VBN
cord-301128-woe6knpv	76	50	to	to	TO
cord-301128-woe6knpv	76	51	achieve	achieve	VB
cord-301128-woe6knpv	76	52	this	this	DT
cord-301128-woe6knpv	76	53	goal	goal	NN
cord-301128-woe6knpv	76	54	.	.	.
cord-301128-woe6knpv	77	1	We	-PRON-	PRP
cord-301128-woe6knpv	77	2	emphasize	emphasize	VBP
cord-301128-woe6knpv	77	3	that	that	IN
cord-301128-woe6knpv	77	4	the	the	DT
cord-301128-woe6knpv	77	5	word	word	NN
cord-301128-woe6knpv	77	6	"	"	``
cord-301128-woe6knpv	77	7	loop	loop	NN
cord-301128-woe6knpv	77	8	"	"	''
cord-301128-woe6knpv	77	9	is	be	VBZ
cord-301128-woe6knpv	77	10	used	use	VBN
cord-301128-woe6knpv	77	11	here	here	RB
cord-301128-woe6knpv	77	12	according	accord	VBG
cord-301128-woe6knpv	77	13	to	to	IN
cord-301128-woe6knpv	77	14	its	-PRON-	PRP$
cord-301128-woe6knpv	77	15	biological	biological	JJ
cord-301128-woe6knpv	77	16	meaning	meaning	NN
cord-301128-woe6knpv	77	17	and	and	CC
cord-301128-woe6knpv	77	18	not	not	RB
cord-301128-woe6knpv	77	19	the	the	DT
cord-301128-woe6knpv	77	20	geometrical	geometrical	JJ
cord-301128-woe6knpv	77	21	one	one	CD
cord-301128-woe6knpv	77	22	.	.	.
cord-301128-woe6knpv	78	1	More	more	RBR
cord-301128-woe6knpv	78	2	precisely	precisely	RB
cord-301128-woe6knpv	78	3	,	,	,
cord-301128-woe6knpv	78	4	it	-PRON-	PRP
cord-301128-woe6knpv	78	5	does	do	VBZ
cord-301128-woe6knpv	78	6	not	not	RB
cord-301128-woe6knpv	78	7	refer	refer	VB
cord-301128-woe6knpv	78	8	to	to	IN
cord-301128-woe6knpv	78	9	a	a	DT
cord-301128-woe6knpv	78	10	closed	closed	JJ
cord-301128-woe6knpv	78	11	curve	curve	NN
cord-301128-woe6knpv	78	12	,	,	,
cord-301128-woe6knpv	78	13	but	but	CC
cord-301128-woe6knpv	78	14	rather	rather	RB
cord-301128-woe6knpv	78	15	to	to	IN
cord-301128-woe6knpv	78	16	a	a	DT
cord-301128-woe6knpv	78	17	conformation	conformation	NN
cord-301128-woe6knpv	78	18	of	of	IN
cord-301128-woe6knpv	78	19	the	the	DT
cord-301128-woe6knpv	78	20	DNA	dna	NN
cord-301128-woe6knpv	78	21	chain	chain	NN
cord-301128-woe6knpv	78	22	,	,	,
cord-301128-woe6knpv	78	23	where	where	WRB
cord-301128-woe6knpv	78	24	two	two	CD
cord-301128-woe6knpv	78	25	DNA	dna	NN
cord-301128-woe6knpv	78	26	sites	site	NNS
cord-301128-woe6knpv	78	27	that	that	WDT
cord-301128-woe6knpv	78	28	are	be	VBP
cord-301128-woe6knpv	78	29	widely	widely	RB
cord-301128-woe6knpv	78	30	separated	separate	VBN
cord-301128-woe6knpv	78	31	from	from	IN
cord-301128-woe6knpv	78	32	the	the	DT
cord-301128-woe6knpv	78	33	genomic	genomic	JJ
cord-301128-woe6knpv	78	34	point	point	NN
cord-301128-woe6knpv	78	35	of	of	IN
cord-301128-woe6knpv	78	36	view	view	NN
cord-301128-woe6knpv	78	37	are	be	VBP
cord-301128-woe6knpv	78	38	maintained	maintain	VBN
cord-301128-woe6knpv	78	39	close	close	RB
cord-301128-woe6knpv	78	40	to	to	IN
cord-301128-woe6knpv	78	41	each	each	DT
cord-301128-woe6knpv	78	42	other	other	JJ
cord-301128-woe6knpv	78	43	by	by	IN
cord-301128-woe6knpv	78	44	some	some	DT
cord-301128-woe6knpv	78	45	other	other	JJ
cord-301128-woe6knpv	78	46	macromolecule	macromolecule	NN
cord-301128-woe6knpv	78	47	,	,	,
cord-301128-woe6knpv	78	48	so	so	IN
cord-301128-woe6knpv	78	49	that	that	IN
cord-301128-woe6knpv	78	50	the	the	DT
cord-301128-woe6knpv	78	51	segment	segment	NN
cord-301128-woe6knpv	78	52	of	of	IN
cord-301128-woe6knpv	78	53	DNA	DNA	NNP
cord-301128-woe6knpv	78	54	located	locate	VBN
cord-301128-woe6knpv	78	55	between	between	IN
cord-301128-woe6knpv	78	56	these	these	DT
cord-301128-woe6knpv	78	57	two	two	CD
cord-301128-woe6knpv	78	58	sites	site	NNS
cord-301128-woe6knpv	78	59	looks	look	VBZ
cord-301128-woe6knpv	78	60	like	like	IN
cord-301128-woe6knpv	78	61	a	a	DT
cord-301128-woe6knpv	78	62	loop	loop	NN
cord-301128-woe6knpv	78	63	when	when	WRB
cord-301128-woe6knpv	78	64	it	-PRON-	PRP
cord-301128-woe6knpv	78	65	is	be	VBZ
cord-301128-woe6knpv	78	66	observed	observe	VBN
cord-301128-woe6knpv	78	67	from	from	IN
cord-301128-woe6knpv	78	68	a	a	DT
cord-301128-woe6knpv	78	69	long	long	JJ
cord-301128-woe6knpv	78	70	distance	distance	NN
cord-301128-woe6knpv	78	71	or	or	CC
cord-301128-woe6knpv	78	72	projected	project	VBN
cord-301128-woe6knpv	78	73	on	on	IN
cord-301128-woe6knpv	78	74	a	a	DT
cord-301128-woe6knpv	78	75	plane	plane	NN
cord-301128-woe6knpv	78	76	.	.	.
cord-301128-woe6knpv	79	1	However	however	RB
cord-301128-woe6knpv	79	2	,	,	,
cord-301128-woe6knpv	79	3	the	the	DT
cord-301128-woe6knpv	79	4	chain	chain	NN
cord-301128-woe6knpv	79	5	is	be	VBZ
cord-301128-woe6knpv	79	6	not	not	RB
cord-301128-woe6knpv	79	7	closed	closed	JJ
cord-301128-woe6knpv	79	8	and	and	CC
cord-301128-woe6knpv	79	9	torsional	torsional	JJ
cord-301128-woe6knpv	79	10	stress	stress	NN
cord-301128-woe6knpv	79	11	can	can	MD
cord-301128-woe6knpv	79	12	not	not	RB
cord-301128-woe6knpv	79	13	diffuse	diffuse	VB
cord-301128-woe6knpv	79	14	directly	directly	RB
cord-301128-woe6knpv	79	15	from	from	IN
cord-301128-woe6knpv	79	16	one	one	CD
cord-301128-woe6knpv	79	17	extremity	extremity	NN
cord-301128-woe6knpv	79	18	of	of	IN
cord-301128-woe6knpv	79	19	the	the	DT
cord-301128-woe6knpv	79	20	loop	loop	NN
cord-301128-woe6knpv	79	21	to	to	IN
cord-301128-woe6knpv	79	22	the	the	DT
cord-301128-woe6knpv	79	23	other	other	JJ
cord-301128-woe6knpv	79	24	one	one	CD
cord-301128-woe6knpv	79	25	through	through	IN
cord-301128-woe6knpv	79	26	the	the	DT
cord-301128-woe6knpv	79	27	bridging	bridge	VBG
cord-301128-woe6knpv	79	28	macromolecule	macromolecule	NN
cord-301128-woe6knpv	79	29	.	.	.
cord-301128-woe6knpv	80	1	In	in	IN
cord-301128-woe6knpv	80	2	order	order	NN
cord-301128-woe6knpv	80	3	to	to	TO
cord-301128-woe6knpv	80	4	ascertain	ascertain	VB
cord-301128-woe6knpv	80	5	this	this	DT
cord-301128-woe6knpv	80	6	point	point	NN
cord-301128-woe6knpv	80	7	,	,	,
cord-301128-woe6knpv	80	8	we	-PRON-	PRP
cord-301128-woe6knpv	80	9	launched	launch	VBD
cord-301128-woe6knpv	80	10	a	a	DT
cord-301128-woe6knpv	80	11	series	series	NN
cord-301128-woe6knpv	80	12	of	of	IN
cord-301128-woe6knpv	80	13	simulations	simulation	NNS
cord-301128-woe6knpv	80	14	with	with	IN
cord-301128-woe6knpv	80	15	the	the	DT
cord-301128-woe6knpv	80	16	crudest	crude	JJS
cord-301128-woe6knpv	80	17	model	model	NN
cord-301128-woe6knpv	80	18	for	for	IN
cord-301128-woe6knpv	80	19	DNA	dna	NN
cord-301128-woe6knpv	80	20	-	-	HYPH
cord-301128-woe6knpv	80	21	bridging	bridge	VBG
cord-301128-woe6knpv	80	22	proteins	protein	NNS
cord-301128-woe6knpv	80	23	,	,	,
cord-301128-woe6knpv	80	24	namely	namely	RB
cord-301128-woe6knpv	80	25	a	a	DT
cord-301128-woe6knpv	80	26	simple	simple	JJ
cord-301128-woe6knpv	80	27	bond	bond	NN
cord-301128-woe6knpv	80	28	between	between	IN
cord-301128-woe6knpv	80	29	beads	bead	NNS
cord-301128-woe6knpv	80	30	α	α	NN
cord-301128-woe6knpv	80	31	and	and	CC
cord-301128-woe6knpv	80	32	β	β	NN
cord-301128-woe6knpv	80	33	.	.	.
cord-301128-woe6knpv	81	1	The	the	DT
cord-301128-woe6knpv	81	2	,	,	,
cord-301128-woe6knpv	81	3	where	where	WRB
cord-301128-woe6knpv	81	4	pot	pot	NN
cord-301128-woe6knpv	81	5	E	e	NN
cord-301128-woe6knpv	81	6	is	be	VBZ
cord-301128-woe6knpv	81	7	the	the	DT
cord-301128-woe6knpv	81	8	energy	energy	NN
cord-301128-woe6knpv	81	9	of	of	IN
cord-301128-woe6knpv	81	10	the	the	DT
cord-301128-woe6knpv	81	11	naked	naked	JJ
cord-301128-woe6knpv	81	12	circular	circular	JJ
cord-301128-woe6knpv	81	13	DNA	dna	NN
cord-301128-woe6knpv	81	14	chain	chain	NN
cord-301128-woe6knpv	81	15	described	describe	VBN
cord-301128-woe6knpv	81	16	in	in	IN
cord-301128-woe6knpv	81	17	Eqs	Eqs	NNP
cord-301128-woe6knpv	81	18	.	.	.
cord-301128-woe6knpv	82	1	(	(	-LRB-
cord-301128-woe6knpv	82	2	S1)-(S5	s1)-(s5	CD
cord-301128-woe6knpv	82	3	)	)	-RRB-
cord-301128-woe6knpv	82	4	and	and	CC
cord-301128-woe6knpv	82	5	BP	BP	NNP
cord-301128-woe6knpv	82	6	E	E	NNP
cord-301128-woe6knpv	83	1	an	an	DT
cord-301128-woe6knpv	83	2	additional	additional	JJ
cord-301128-woe6knpv	83	3	term	term	NN
cord-301128-woe6knpv	83	4	,	,	,
cord-301128-woe6knpv	83	5	which	which	WDT
cord-301128-woe6knpv	83	6	models	model	VBZ
cord-301128-woe6knpv	83	7	the	the	DT
cord-301128-woe6knpv	83	8	action	action	NN
cord-301128-woe6knpv	83	9	of	of	IN
cord-301128-woe6knpv	83	10	DNA	dna	NN
cord-301128-woe6knpv	83	11	-	-	HYPH
cord-301128-woe6knpv	83	12	bridging	bridge	VBG
cord-301128-woe6knpv	83	13	proteins	protein	NNS
cord-301128-woe6knpv	83	14	.	.	.
cord-301128-woe6knpv	84	1	For	for	IN
cord-301128-woe6knpv	84	2	the	the	DT
cord-301128-woe6knpv	84	3	simplest	simple	JJS
cord-301128-woe6knpv	84	4	model	model	NN
cord-301128-woe6knpv	84	5	,	,	,
cord-301128-woe6knpv	84	6	we	-PRON-	PRP
cord-301128-woe6knpv	84	7	used	use	VBD
cord-301128-woe6knpv	84	8	where	where	WRB
cord-301128-woe6knpv	84	9	d	d	XX
cord-301128-woe6knpv	84	10	αβ	αβ	NN
cord-301128-woe6knpv	84	11	is	be	VBZ
cord-301128-woe6knpv	84	12	the	the	DT
cord-301128-woe6knpv	84	13	distance	distance	NN
cord-301128-woe6knpv	84	14	between	between	IN
cord-301128-woe6knpv	84	15	the	the	DT
cord-301128-woe6knpv	84	16	centers	center	NNS
cord-301128-woe6knpv	84	17	of	of	IN
cord-301128-woe6knpv	84	18	beads	bead	NNS
cord-301128-woe6knpv	84	19	α	α	NN
cord-301128-woe6knpv	84	20	and	and	CC
cord-301128-woe6knpv	84	21	β	β	NN
cord-301128-woe6knpv	84	22	and	and	CC
cord-301128-woe6knpv	84	23	0	0	CD
cord-301128-woe6knpv	84	24	4	4	CD
cord-301128-woe6knpv	84	25	d	d	NN
cord-301128-woe6knpv	84	26	αβ	αβ	NN
cord-301128-woe6knpv	84	27	=	=	NN
cord-301128-woe6knpv	84	28	nm	nm	NN
cord-301128-woe6knpv	84	29	.	.	.
cord-301128-woe6knpv	85	1	For	for	IN
cord-301128-woe6knpv	85	2	the	the	DT
cord-301128-woe6knpv	85	3	sake	sake	NN
cord-301128-woe6knpv	85	4	of	of	IN
cord-301128-woe6knpv	85	5	simplicity	simplicity	NN
cord-301128-woe6knpv	85	6	,	,	,
cord-301128-woe6knpv	85	7	we	-PRON-	PRP
cord-301128-woe6knpv	85	8	used	use	VBD
cord-301128-woe6knpv	85	9	the	the	DT
cord-301128-woe6knpv	85	10	same	same	JJ
cord-301128-woe6knpv	85	11	value	value	NN
cord-301128-woe6knpv	85	12	of	of	IN
cord-301128-woe6knpv	85	13	the	the	DT
cord-301128-woe6knpv	85	14	stretching	stretching	NN
cord-301128-woe6knpv	85	15	rigidity	rigidity	NN
cord-301128-woe6knpv	85	16	as	as	IN
cord-301128-woe6knpv	85	17	for	for	IN
cord-301128-woe6knpv	85	18	the	the	DT
cord-301128-woe6knpv	85	19	DNA	dna	NN
cord-301128-woe6knpv	85	20	chain	chain	NN
cord-301128-woe6knpv	85	21	,	,	,
cord-301128-woe6knpv	85	22	that	that	RB
cord-301128-woe6knpv	85	23	is	be	VBZ
cord-301128-woe6knpv	85	24	topological	topological	JJ
cord-301128-woe6knpv	85	25	barriers	barrier	NNS
cord-301128-woe6knpv	85	26	is	be	VBZ
cord-301128-woe6knpv	85	27	consequently	consequently	RB
cord-301128-woe6knpv	85	28	related	relate	VBN
cord-301128-woe6knpv	85	29	to	to	IN
cord-301128-woe6knpv	85	30	some	some	DT
cord-301128-woe6knpv	85	31	property	property	NN
cord-301128-woe6knpv	85	32	,	,	,
cord-301128-woe6knpv	85	33	which	which	WDT
cord-301128-woe6knpv	85	34	is	be	VBZ
cord-301128-woe6knpv	85	35	subtler	subtle	JJR
cord-301128-woe6knpv	85	36	than	than	IN
cord-301128-woe6knpv	85	37	the	the	DT
cord-301128-woe6knpv	85	38	mere	mere	JJ
cord-301128-woe6knpv	85	39	connection	connection	NN
cord-301128-woe6knpv	85	40	between	between	IN
cord-301128-woe6knpv	85	41	two	two	CD
cord-301128-woe6knpv	85	42	genetically	genetically	RB
cord-301128-woe6knpv	85	43	widely	widely	RB
cord-301128-woe6knpv	85	44	separated	separate	VBN
cord-301128-woe6knpv	85	45	DNA	dna	NN
cord-301128-woe6knpv	85	46	sites	site	NNS
cord-301128-woe6knpv	85	47	.	.	.
cord-301128-woe6knpv	86	1	Still	still	RB
cord-301128-woe6knpv	86	2	,	,	,
cord-301128-woe6knpv	86	3	it	-PRON-	PRP
cord-301128-woe6knpv	86	4	is	be	VBZ
cord-301128-woe6knpv	86	5	worth	worth	JJ
cord-301128-woe6knpv	86	6	noting	note	VBG
cord-301128-woe6knpv	86	7	that	that	IN
cord-301128-woe6knpv	86	8	the	the	DT
cord-301128-woe6knpv	86	9	αβ	αβ	NNP
cord-301128-woe6knpv	86	10	bond	bond	NN
cord-301128-woe6knpv	86	11	has	have	VBZ
cord-301128-woe6knpv	86	12	a	a	DT
cord-301128-woe6knpv	86	13	significant	significant	JJ
cord-301128-woe6knpv	86	14	effect	effect	NN
cord-301128-woe6knpv	86	15	on	on	IN
cord-301128-woe6knpv	86	16	the	the	DT
cord-301128-woe6knpv	86	17	time	time	NN
cord-301128-woe6knpv	86	18	evolution	evolution	NN
cord-301128-woe6knpv	86	19	of	of	IN
cord-301128-woe6knpv	86	20	12	12	CD
cord-301128-woe6knpv	86	21	r	r	NNP
cord-301128-woe6knpv	86	22	W	W	NNP
cord-301128-woe6knpv	86	23	,	,	,
cord-301128-woe6knpv	86	24	as	as	IN
cord-301128-woe6knpv	86	25	can	can	MD
cord-301128-woe6knpv	86	26	be	be	VB
cord-301128-woe6knpv	86	27	checked	check	VBN
cord-301128-woe6knpv	86	28	in	in	IN
cord-301128-woe6knpv	86	29	Fig	Fig	NNP
cord-301128-woe6knpv	86	30	.	.	.
cord-301128-woe6knpv	86	31	S5	S5	NNP
cord-301128-woe6knpv	86	32	.	.	.
cord-301128-woe6knpv	87	1	The	the	DT
cord-301128-woe6knpv	87	2	reason	reason	NN
cord-301128-woe6knpv	87	3	is	be	VBZ
cord-301128-woe6knpv	87	4	the	the	DT
cord-301128-woe6knpv	87	5	following	follow	VBG
cord-301128-woe6knpv	87	6	.	.	.
cord-301128-woe6knpv	88	1	In	in	IN
cord-301128-woe6knpv	88	2	order	order	NN
cord-301128-woe6knpv	88	3	to	to	TO
cord-301128-woe6knpv	88	4	compute	compute	VB
cord-301128-woe6knpv	88	5	the	the	DT
cord-301128-woe6knpv	88	6	partial	partial	JJ
cord-301128-woe6knpv	88	7	writhes	writhe	NNS
cord-301128-woe6knpv	88	8	r	r	NNP
cord-301128-woe6knpv	88	9	j	j	NNP
cord-301128-woe6knpv	88	10	W	W	NNP
cord-301128-woe6knpv	88	11	(	(	-LRB-
cord-301128-woe6knpv	88	12	see	see	VB
cord-301128-woe6knpv	88	13	the	the	DT
cord-301128-woe6knpv	88	14	Supporting	Supporting	NNP
cord-301128-woe6knpv	88	15	Material	Material	NNP
cord-301128-woe6knpv	88	16	)	)	-RRB-
cord-301128-woe6knpv	88	17	,	,	,
cord-301128-woe6knpv	88	18	one	one	PRP
cord-301128-woe6knpv	88	19	has	have	VBZ
cord-301128-woe6knpv	88	20	to	to	TO
cord-301128-woe6knpv	88	21	introduce	introduce	VB
cord-301128-woe6knpv	88	22	two	two	CD
cord-301128-woe6knpv	88	23	"	"	``
cord-301128-woe6knpv	88	24	virtual	virtual	JJ
cord-301128-woe6knpv	88	25	"	"	''
cord-301128-woe6knpv	88	26	closed	close	VBN
cord-301128-woe6knpv	88	27	chains	chain	NNS
cord-301128-woe6knpv	88	28	1	1	CD
cord-301128-woe6knpv	88	29	C	C	NNP
cord-301128-woe6knpv	88	30	and	and	CC
cord-301128-woe6knpv	88	31	2	2	CD
cord-301128-woe6knpv	88	32	C	c	NN
cord-301128-woe6knpv	88	33	.	.	.
cord-301128-woe6knpv	89	1	1	1	CD
cord-301128-woe6knpv	89	2	C	C	NNP
cord-301128-woe6knpv	89	3	is	be	VBZ
cord-301128-woe6knpv	89	4	composed	compose	VBN
cord-301128-woe6knpv	89	5	of	of	IN
cord-301128-woe6knpv	89	6	beads	bead	NNS
cord-301128-woe6knpv	89	7	α	α	NN
cord-301128-woe6knpv	89	8	to	to	IN
cord-301128-woe6knpv	89	9	1	1	CD
cord-301128-woe6knpv	89	10	β	β	NN
cord-301128-woe6knpv	89	11	−	−	NNP
cord-301128-woe6knpv	89	12	,	,	,
cord-301128-woe6knpv	89	13	plus	plus	CC
cord-301128-woe6knpv	89	14	the	the	DT
cord-301128-woe6knpv	89	15	"	"	``
cord-301128-woe6knpv	89	16	unphysical	unphysical	JJ
cord-301128-woe6knpv	89	17	"	"	''
cord-301128-woe6knpv	89	18	segment	segment	NN
cord-301128-woe6knpv	89	19	between	between	IN
cord-301128-woe6knpv	89	20	beads	bead	NNS
cord-301128-woe6knpv	89	21	β	β	NNP
cord-301128-woe6knpv	89	22	and	and	CC
cord-301128-woe6knpv	89	23	α	α	NNP
cord-301128-woe6knpv	89	24	,	,	,
cord-301128-woe6knpv	89	25	while	while	IN
cord-301128-woe6knpv	89	26	2	2	CD
cord-301128-woe6knpv	89	27	C	C	NNP
cord-301128-woe6knpv	89	28	is	be	VBZ
cord-301128-woe6knpv	89	29	composed	compose	VBN
cord-301128-woe6knpv	89	30	of	of	IN
cord-301128-woe6knpv	89	31	beads	bead	NNS
cord-301128-woe6knpv	89	32	β	β	XX
cord-301128-woe6knpv	89	33	to	to	IN
cord-301128-woe6knpv	89	34	1	1	CD
cord-301128-woe6knpv	89	35	α	α	NN
cord-301128-woe6knpv	89	36	−	−	NNP
cord-301128-woe6knpv	89	37	,	,	,
cord-301128-woe6knpv	89	38	plus	plus	CC
cord-301128-woe6knpv	89	39	the	the	DT
cord-301128-woe6knpv	89	40	same	same	JJ
cord-301128-woe6knpv	89	41	"	"	``
cord-301128-woe6knpv	89	42	unphysical	unphysical	JJ
cord-301128-woe6knpv	89	43	"	"	''
cord-301128-woe6knpv	89	44	segment	segment	NN
cord-301128-woe6knpv	89	45	between	between	IN
cord-301128-woe6knpv	89	46	beads	bead	NNS
cord-301128-woe6knpv	89	47	α	α	NN
cord-301128-woe6knpv	89	48	and	and	CC
cord-301128-woe6knpv	89	49	β	β	NN
cord-301128-woe6knpv	89	50	.	.	.
cord-301128-woe6knpv	90	1	When	when	WRB
cord-301128-woe6knpv	90	2	beads	bead	NNS
cord-301128-woe6knpv	90	3	α	α	NN
cord-301128-woe6knpv	90	4	and	and	CC
cord-301128-woe6knpv	90	5	β	β	NN
cord-301128-woe6knpv	90	6	are	be	VBP
cord-301128-woe6knpv	90	7	bonded	bond	VBN
cord-301128-woe6knpv	90	8	,	,	,
cord-301128-woe6knpv	90	9	they	-PRON-	PRP
cord-301128-woe6knpv	90	10	remain	remain	VBP
cord-301128-woe6knpv	90	11	close	close	JJ
cord-301128-woe6knpv	90	12	to	to	IN
cord-301128-woe6knpv	90	13	each	each	DT
cord-301128-woe6knpv	90	14	other	other	JJ
cord-301128-woe6knpv	90	15	for	for	IN
cord-301128-woe6knpv	90	16	0	0	CD
cord-301128-woe6knpv	90	17	t	t	NN
cord-301128-woe6knpv	90	18	>	>	XX
cord-301128-woe6knpv	90	19	,	,	,
cord-301128-woe6knpv	90	20	as	as	IN
cord-301128-woe6knpv	90	21	indicated	indicate	VBN
cord-301128-woe6knpv	90	22	by	by	IN
cord-301128-woe6knpv	90	23	the	the	DT
cord-301128-woe6knpv	90	24	positions	position	NNS
cord-301128-woe6knpv	90	25	of	of	IN
cord-301128-woe6knpv	90	26	the	the	DT
cord-301128-woe6knpv	90	27	two	two	CD
cord-301128-woe6knpv	90	28	arrows	arrow	NNS
cord-301128-woe6knpv	90	29	in	in	IN
cord-301128-woe6knpv	90	30	Fig	Fig	NNP
cord-301128-woe6knpv	90	31	.	.	.
cord-301128-woe6knpv	90	32	3(a	3(a	CD
cord-301128-woe6knpv	90	33	)	)	-RRB-
cord-301128-woe6knpv	90	34	,	,	,
cord-301128-woe6knpv	90	35	so	so	IN
cord-301128-woe6knpv	90	36	that	that	IN
cord-301128-woe6knpv	90	37	the	the	DT
cord-301128-woe6knpv	90	38	unphysical	unphysical	JJ
cord-301128-woe6knpv	90	39	segment	segment	NN
cord-301128-woe6knpv	90	40	between	between	IN
cord-301128-woe6knpv	90	41	beads	bead	NNS
cord-301128-woe6knpv	90	42	α	α	NNP
cord-301128-woe6knpv	90	43	and	and	CC
cord-301128-woe6knpv	90	44	β	β	NN
cord-301128-woe6knpv	90	45	remains	remain	VBZ
cord-301128-woe6knpv	90	46	small	small	JJ
cord-301128-woe6knpv	90	47	and	and	CC
cord-301128-woe6knpv	90	48	1	1	CD
cord-301128-woe6knpv	90	49	C	c	NN
cord-301128-woe6knpv	90	50	is	be	VBZ
cord-301128-woe6knpv	90	51	a	a	DT
cord-301128-woe6knpv	90	52	good	good	JJ
cord-301128-woe6knpv	90	53	representation	representation	NN
cord-301128-woe6knpv	90	54	of	of	IN
cord-301128-woe6knpv	90	55	the	the	DT
cord-301128-woe6knpv	90	56	initially	initially	RB
cord-301128-woe6knpv	90	57	torsionally	torsionally	RB
cord-301128-woe6knpv	90	58	relaxed	relaxed	JJ
cord-301128-woe6knpv	90	59	DNA	dna	NN
cord-301128-woe6knpv	90	60	loop	loop	NN
cord-301128-woe6knpv	90	61	(	(	-LRB-
cord-301128-woe6knpv	90	62	and	and	CC
cord-301128-woe6knpv	90	63	1	1	CD
cord-301128-woe6knpv	90	64	r	r	NN
cord-301128-woe6knpv	90	65	W	w	NN
cord-301128-woe6knpv	90	66	is	be	VBZ
cord-301128-woe6knpv	90	67	a	a	DT
cord-301128-woe6knpv	90	68	measure	measure	NN
cord-301128-woe6knpv	90	69	of	of	IN
cord-301128-woe6knpv	90	70	its	-PRON-	PRP$
cord-301128-woe6knpv	90	71	writhe	writhe	NN
cord-301128-woe6knpv	90	72	)	)	-RRB-
cord-301128-woe6knpv	91	1	,	,	,
cord-301128-woe6knpv	91	2	2	2	CD
cord-301128-woe6knpv	91	3	C	C	NNP
cord-301128-woe6knpv	91	4	is	be	VBZ
cord-301128-woe6knpv	91	5	a	a	DT
cord-301128-woe6knpv	91	6	good	good	JJ
cord-301128-woe6knpv	91	7	representation	representation	NN
cord-301128-woe6knpv	91	8	of	of	IN
cord-301128-woe6knpv	91	9	the	the	DT
cord-301128-woe6knpv	91	10	initially	initially	RB
cord-301128-woe6knpv	91	11	torsionally	torsionally	RB
cord-301128-woe6knpv	91	12	stressed	stress	VBD
cord-301128-woe6knpv	91	13	DNA	dna	NN
cord-301128-woe6knpv	91	14	loop	loop	NN
cord-301128-woe6knpv	91	15	(	(	-LRB-
cord-301128-woe6knpv	91	16	and	and	CC
cord-301128-woe6knpv	91	17	2	2	CD
cord-301128-woe6knpv	91	18	r	r	NN
cord-301128-woe6knpv	91	19	W	w	NN
cord-301128-woe6knpv	91	20	is	be	VBZ
cord-301128-woe6knpv	91	21	a	a	DT
cord-301128-woe6knpv	91	22	measure	measure	NN
cord-301128-woe6knpv	91	23	of	of	IN
cord-301128-woe6knpv	91	24	its	-PRON-	PRP$
cord-301128-woe6knpv	91	25	writhe	writhe	NN
cord-301128-woe6knpv	91	26	)	)	-RRB-
cord-301128-woe6knpv	91	27	,	,	,
cord-301128-woe6knpv	91	28	and	and	CC
cord-301128-woe6knpv	91	29	12	12	CD
cord-301128-woe6knpv	91	30	r	r	NN
cord-301128-woe6knpv	91	31	W	w	NN
cord-301128-woe6knpv	91	32	is	be	VBZ
cord-301128-woe6knpv	91	33	a	a	DT
cord-301128-woe6knpv	91	34	measure	measure	NN
cord-301128-woe6knpv	91	35	of	of	IN
cord-301128-woe6knpv	91	36	the	the	DT
cord-301128-woe6knpv	91	37	intrication	intrication	NN
cord-301128-woe6knpv	91	38	of	of	IN
cord-301128-woe6knpv	91	39	the	the	DT
cord-301128-woe6knpv	91	40	two	two	CD
cord-301128-woe6knpv	91	41	loops	loop	NNS
cord-301128-woe6knpv	91	42	.	.	.
cord-301128-woe6knpv	92	1	In	in	IN
cord-301128-woe6knpv	92	2	this	this	DT
cord-301128-woe6knpv	92	3	case	case	NN
cord-301128-woe6knpv	92	4	,	,	,
cord-301128-woe6knpv	92	5	12	12	CD
cord-301128-woe6knpv	92	6	r	r	NNP
cord-301128-woe6knpv	92	7	W	W	NNP
cord-301128-woe6knpv	92	8	remains	remain	VBZ
cord-301128-woe6knpv	92	9	close	close	JJ
cord-301128-woe6knpv	92	10	to	to	IN
cord-301128-woe6knpv	92	11	zero	zero	CD
cord-301128-woe6knpv	92	12	at	at	IN
cord-301128-woe6knpv	92	13	all	all	DT
cord-301128-woe6knpv	92	14	times	time	NNS
cord-301128-woe6knpv	92	15	,	,	,
cord-301128-woe6knpv	92	16	as	as	IN
cord-301128-woe6knpv	92	17	can	can	MD
cord-301128-woe6knpv	92	18	be	be	VB
cord-301128-woe6knpv	92	19	checked	check	VBN
cord-301128-woe6knpv	92	20	in	in	IN
cord-301128-woe6knpv	92	21	Fig	Fig	NNP
cord-301128-woe6knpv	92	22	.	.	.
cord-301128-woe6knpv	93	1	S5(b	S5(b	NNP
cord-301128-woe6knpv	93	2	)	)	-RRB-
cord-301128-woe6knpv	93	3	.	.	.
cord-301128-woe6knpv	94	1	This	this	DT
cord-301128-woe6knpv	94	2	indicates	indicate	VBZ
cord-301128-woe6knpv	94	3	that	that	IN
cord-301128-woe6knpv	94	4	,	,	,
cord-301128-woe6knpv	94	5	for	for	IN
cord-301128-woe6knpv	94	6	bridged	bridge	VBN
cord-301128-woe6knpv	94	7	DNA	dna	NN
cord-301128-woe6knpv	94	8	,	,	,
cord-301128-woe6knpv	94	9	equilibration	equilibration	NN
cord-301128-woe6knpv	94	10	of	of	IN
cord-301128-woe6knpv	94	11	the	the	DT
cord-301128-woe6knpv	94	12	torsional	torsional	JJ
cord-301128-woe6knpv	94	13	stress	stress	NN
cord-301128-woe6knpv	94	14	is	be	VBZ
cord-301128-woe6knpv	94	15	not	not	RB
cord-301128-woe6knpv	94	16	accompanied	accompany	VBN
cord-301128-woe6knpv	94	17	by	by	IN
cord-301128-woe6knpv	94	18	any	any	DT
cord-301128-woe6knpv	94	19	significant	significant	JJ
cord-301128-woe6knpv	94	20	intrication	intrication	NN
cord-301128-woe6knpv	94	21	of	of	IN
cord-301128-woe6knpv	94	22	the	the	DT
cord-301128-woe6knpv	94	23	two	two	CD
cord-301128-woe6knpv	94	24	circular	circular	JJ
cord-301128-woe6knpv	94	25	moieties	moiety	NNS
cord-301128-woe6knpv	94	26	.	.	.
cord-301128-woe6knpv	95	1	In	in	IN
cord-301128-woe6knpv	95	2	contrast	contrast	NN
cord-301128-woe6knpv	95	3	,	,	,
cord-301128-woe6knpv	95	4	for	for	IN
cord-301128-woe6knpv	95	5	the	the	DT
cord-301128-woe6knpv	95	6	system	system	NN
cord-301128-woe6knpv	95	7	without	without	IN
cord-301128-woe6knpv	95	8	the	the	DT
cord-301128-woe6knpv	95	9	BP	BP	NNP
cord-301128-woe6knpv	95	10	E	E	NNP
cord-301128-woe6knpv	95	11	term	term	NN
cord-301128-woe6knpv	95	12	,	,	,
cord-301128-woe6knpv	95	13	beads	bead	NNS
cord-301128-woe6knpv	95	14	α	α	NN
cord-301128-woe6knpv	95	15	and	and	CC
cord-301128-woe6knpv	95	16	β	β	NN
cord-301128-woe6knpv	95	17	do	do	VBP
cord-301128-woe6knpv	95	18	not	not	RB
cord-301128-woe6knpv	95	19	remain	remain	VB
cord-301128-woe6knpv	95	20	close	close	JJ
cord-301128-woe6knpv	95	21	to	to	IN
cord-301128-woe6knpv	95	22	each	each	DT
cord-301128-woe6knpv	95	23	other	other	JJ
cord-301128-woe6knpv	95	24	for	for	IN
cord-301128-woe6knpv	95	25	0	0	CD
cord-301128-woe6knpv	95	26	t	t	NN
cord-301128-woe6knpv	95	27	>	>	XX
cord-301128-woe6knpv	95	28	,	,	,
cord-301128-woe6knpv	95	29	as	as	IN
cord-301128-woe6knpv	95	30	indicated	indicate	VBN
cord-301128-woe6knpv	95	31	by	by	IN
cord-301128-woe6knpv	95	32	the	the	DT
cord-301128-woe6knpv	95	33	positions	position	NNS
cord-301128-woe6knpv	95	34	of	of	IN
cord-301128-woe6knpv	95	35	the	the	DT
cord-301128-woe6knpv	95	36	two	two	CD
cord-301128-woe6knpv	95	37	arrows	arrow	NNS
cord-301128-woe6knpv	95	38	in	in	IN
cord-301128-woe6knpv	95	39	Fig	Fig	NNP
cord-301128-woe6knpv	95	40	.	.	.
cord-301128-woe6knpv	95	41	1(c	1(c	CD
cord-301128-woe6knpv	95	42	)	)	-RRB-
cord-301128-woe6knpv	95	43	,	,	,
cord-301128-woe6knpv	95	44	so	so	IN
cord-301128-woe6knpv	95	45	that	that	IN
cord-301128-woe6knpv	95	46	the	the	DT
cord-301128-woe6knpv	95	47	unphysical	unphysical	JJ
cord-301128-woe6knpv	95	48	segment	segment	NN
cord-301128-woe6knpv	95	49	between	between	IN
cord-301128-woe6knpv	95	50	beads	bead	NNS
cord-301128-woe6knpv	95	51	α	α	NNP
cord-301128-woe6knpv	95	52	and	and	CC
cord-301128-woe6knpv	95	53	β	β	NN
cord-301128-woe6knpv	95	54	becomes	become	VBZ
cord-301128-woe6knpv	95	55	arbitrarily	arbitrarily	RB
cord-301128-woe6knpv	95	56	large	large	JJ
cord-301128-woe6knpv	95	57	and	and	CC
cord-301128-woe6knpv	95	58	1	1	CD
cord-301128-woe6knpv	95	59	C	c	NN
cord-301128-woe6knpv	95	60	,	,	,
cord-301128-woe6knpv	95	61	2	2	CD
cord-301128-woe6knpv	95	62	C	c	NN
cord-301128-woe6knpv	95	63	,	,	,
cord-301128-woe6knpv	96	1	the	the	DT
cord-301128-woe6knpv	96	2	r	r	NNP
cord-301128-woe6knpv	96	3	j	j	NNP
cord-301128-woe6knpv	96	4	W	W	NNP
cord-301128-woe6knpv	96	5	and	and	CC
cord-301128-woe6knpv	96	6	12	12	CD
cord-301128-woe6knpv	96	7	r	r	NN
cord-301128-woe6knpv	96	8	W	W	NNP
cord-301128-woe6knpv	96	9	lose	lose	VB
cord-301128-woe6knpv	96	10	their	-PRON-	PRP$
cord-301128-woe6knpv	96	11	physical	physical	JJ
cord-301128-woe6knpv	96	12	meaning	meaning	NN
cord-301128-woe6knpv	96	13	.	.	.
cord-301128-woe6knpv	97	1	In	in	IN
cord-301128-woe6knpv	97	2	this	this	DT
cord-301128-woe6knpv	97	3	case	case	NN
cord-301128-woe6knpv	97	4	12	12	CD
cord-301128-woe6knpv	97	5	r	r	NN
cord-301128-woe6knpv	97	6	W	w	NN
cord-301128-woe6knpv	97	7	varies	vary	VBZ
cord-301128-woe6knpv	97	8	quite	quite	RB
cord-301128-woe6knpv	97	9	widely	widely	RB
cord-301128-woe6knpv	97	10	with	with	IN
cord-301128-woe6knpv	97	11	changing	change	VBG
cord-301128-woe6knpv	97	12	DNA	dna	NN
cord-301128-woe6knpv	97	13	conformations	conformation	NNS
cord-301128-woe6knpv	97	14	,	,	,
cord-301128-woe6knpv	97	15	as	as	IN
cord-301128-woe6knpv	97	16	is	be	VBZ
cord-301128-woe6knpv	97	17	illustrated	illustrate	VBN
cord-301128-woe6knpv	97	18	in	in	IN
cord-301128-woe6knpv	97	19	Fig	Fig	NNP
cord-301128-woe6knpv	97	20	.	.	.
cord-301128-woe6knpv	98	1	S5	S5	NNP
cord-301128-woe6knpv	98	2	 	 	_SP
cord-301128-woe6knpv	99	1	The	the	DT
cord-301128-woe6knpv	99	2	reason	reason	NN
cord-301128-woe6knpv	99	3	why	why	WRB
cord-301128-woe6knpv	99	4	forming	form	VBG
cord-301128-woe6knpv	99	5	a	a	DT
cord-301128-woe6knpv	99	6	loop	loop	NN
cord-301128-woe6knpv	99	7	is	be	VBZ
cord-301128-woe6knpv	99	8	not	not	RB
cord-301128-woe6knpv	99	9	sufficient	sufficient	JJ
cord-301128-woe6knpv	99	10	to	to	TO
cord-301128-woe6knpv	99	11	create	create	VB
cord-301128-woe6knpv	99	12	independent	independent	JJ
cord-301128-woe6knpv	99	13	topological	topological	JJ
cord-301128-woe6knpv	99	14	domains	domain	NNS
cord-301128-woe6knpv	99	15	is	be	VBZ
cord-301128-woe6knpv	99	16	of	of	IN
cord-301128-woe6knpv	99	17	course	course	NN
cord-301128-woe6knpv	99	18	that	that	IN
cord-301128-woe6knpv	99	19	the	the	DT
cord-301128-woe6knpv	99	20	bond	bond	NN
cord-301128-woe6knpv	99	21	between	between	IN
cord-301128-woe6knpv	99	22	beads	bead	NNS
cord-301128-woe6knpv	99	23	α	α	NNP
cord-301128-woe6knpv	99	24	and	and	CC
cord-301128-woe6knpv	99	25	β	β	NN
cord-301128-woe6knpv	99	26	described	describe	VBD
cord-301128-woe6knpv	99	27	in	in	IN
cord-301128-woe6knpv	99	28	the	the	DT
cord-301128-woe6knpv	99	29	previous	previous	JJ
cord-301128-woe6knpv	99	30	subsection	subsection	NN
cord-301128-woe6knpv	99	31	is	be	VBZ
cord-301128-woe6knpv	99	32	not	not	RB
cord-301128-woe6knpv	99	33	able	able	JJ
cord-301128-woe6knpv	99	34	to	to	TO
cord-301128-woe6knpv	99	35	block	block	VB
cord-301128-woe6knpv	99	36	the	the	DT
cord-301128-woe6knpv	99	37	rapid	rapid	JJ
cord-301128-woe6knpv	99	38	diffusion	diffusion	NN
cord-301128-woe6knpv	99	39	of	of	IN
cord-301128-woe6knpv	99	40	the	the	DT
cord-301128-woe6knpv	99	41	excess	excess	NN
cord-301128-woe6knpv	99	42	of	of	IN
cord-301128-woe6knpv	99	43	twist	twist	NN
cord-301128-woe6knpv	99	44	through	through	IN
cord-301128-woe6knpv	99	45	beads	bead	NNS
cord-301128-woe6knpv	99	46	α	α	NN
cord-301128-woe6knpv	99	47	and	and	CC
cord-301128-woe6knpv	99	48	β	β	NN
cord-301128-woe6knpv	99	49	and	and	CC
cord-301128-woe6knpv	99	50	the	the	DT
cord-301128-woe6knpv	99	51	subsequent	subsequent	JJ
cord-301128-woe6knpv	99	52	equilibration	equilibration	NN
cord-301128-woe6knpv	99	53	of	of	IN
cord-301128-woe6knpv	99	54	the	the	DT
cord-301128-woe6knpv	99	55	writhe	writhe	NN
cord-301128-woe6knpv	99	56	.	.	.
cord-301128-woe6knpv	100	1	In	in	IN
cord-301128-woe6knpv	100	2	order	order	NN
cord-301128-woe6knpv	100	3	to	to	TO
cord-301128-woe6knpv	100	4	form	form	VB
cord-301128-woe6knpv	100	5	independent	independent	JJ
cord-301128-woe6knpv	100	6	topological	topological	JJ
cord-301128-woe6knpv	100	7	domains	domain	NNS
cord-301128-woe6knpv	100	8	,	,	,
cord-301128-woe6knpv	100	9	the	the	DT
cord-301128-woe6knpv	100	10	diffusion	diffusion	NN
cord-301128-woe6knpv	100	11	of	of	IN
cord-301128-woe6knpv	100	12	the	the	DT
cord-301128-woe6knpv	100	13	excess	excess	NN
cord-301128-woe6knpv	100	14	of	of	IN
cord-301128-woe6knpv	100	15	twist	twist	NN
cord-301128-woe6knpv	100	16	must	must	MD
cord-301128-woe6knpv	100	17	absolutely	absolutely	RB
cord-301128-woe6knpv	100	18	be	be	VB
cord-301128-woe6knpv	100	19	blocked	block	VBN
cord-301128-woe6knpv	100	20	.	.	.
cord-301128-woe6knpv	101	1	Stated	state	VBN
cord-301128-woe6knpv	101	2	in	in	IN
cord-301128-woe6knpv	101	3	other	other	JJ
cord-301128-woe6knpv	101	4	words	word	NNS
cord-301128-woe6knpv	101	5	,	,	,
cord-301128-woe6knpv	101	6	rotation	rotation	NN
cord-301128-woe6knpv	101	7	of	of	IN
cord-301128-woe6knpv	101	8	the	the	DT
cord-301128-woe6knpv	101	9	internal	internal	JJ
cord-301128-woe6knpv	101	10	basis	basis	NN
cord-301128-woe6knpv	101	11	(	(	-LRB-
cord-301128-woe6knpv	101	12	,	,	,
cord-301128-woe6knpv	101	13	,	,	,
cord-301128-woe6knpv	101	14	)	)	-RRB-
cord-301128-woe6knpv	102	1	k	k	NNP
cord-301128-woe6knpv	102	2	k	k	NNP
cord-301128-woe6knpv	102	3	k	k	NNP
cord-301128-woe6knpv	102	4	u	u	NN
cord-301128-woe6knpv	102	5	f	f	NNP
cord-301128-woe6knpv	102	6	v	v	NN
cord-301128-woe6knpv	102	7	around	around	RB
cord-301128-woe6knpv	103	1	k	k	NNP
cord-301128-woe6knpv	103	2	u	u	NNP
cord-301128-woe6knpv	103	3	must	must	MD
cord-301128-woe6knpv	103	4	be	be	VB
cord-301128-woe6knpv	103	5	forbidden	forbid	VBN
cord-301128-woe6knpv	103	6	at	at	IN
cord-301128-woe6knpv	103	7	,	,	,
cord-301128-woe6knpv	103	8	From	from	IN
cord-301128-woe6knpv	103	9	 	 	_SP
cord-301128-woe6knpv	103	10	for	for	IN
cord-301128-woe6knpv	103	11	,	,	,
cord-301128-woe6knpv	103	12	We	-PRON-	PRP
cord-301128-woe6knpv	103	13	note	note	VBP
cord-301128-woe6knpv	103	14	that	that	IN
cord-301128-woe6knpv	103	15	the	the	DT
cord-301128-woe6knpv	103	16	k	k	NN
cord-301128-woe6knpv	103	17	δ	δ	NNP
cord-301128-woe6knpv	103	18	remain	remain	VBP
cord-301128-woe6knpv	103	19	small	small	JJ
cord-301128-woe6knpv	103	20	,	,	,
cord-301128-woe6knpv	103	21	and	and	CC
cord-301128-woe6knpv	103	22	the	the	DT
cord-301128-woe6knpv	103	23	corrections	correction	NNS
cord-301128-woe6knpv	103	24	in	in	IN
cord-301128-woe6knpv	103	25	Eq	Eq	NNP
cord-301128-woe6knpv	103	26	.	.	.
cord-301128-woe6knpv	104	1	(	(	-LRB-
cord-301128-woe6knpv	104	2	5	5	LS
cord-301128-woe6knpv	104	3	)	)	-RRB-
cord-301128-woe6knpv	104	4	 	 	_SP
cord-301128-woe6knpv	105	1	where	where	WRB
cord-301128-woe6knpv	105	2	α	α	NNP
cord-301128-woe6knpv	105	3	ξ	ξ	NNP
cord-301128-woe6knpv	105	4	denotes	denote	VBZ
cord-301128-woe6knpv	105	5	the	the	DT
cord-301128-woe6knpv	105	6	angle	angle	NN
cord-301128-woe6knpv	105	7	formed	form	VBN
cord-301128-woe6knpv	105	8	by	by	IN
cord-301128-woe6knpv	105	9	beads	bead	NNS
cord-301128-woe6knpv	105	10	β	β	NNP
cord-301128-woe6knpv	105	11	,	,	,
cord-301128-woe6knpv	105	12	α	α	NN
cord-301128-woe6knpv	105	13	and	and	CC
cord-301128-woe6knpv	105	14	1	1	CD
cord-301128-woe6knpv	105	15	α	α	NN
cord-301128-woe6knpv	105	16	+	+	CC
cord-301128-woe6knpv	105	17	,	,	,
cord-301128-woe6knpv	105	18	and	and	CC
cord-301128-woe6knpv	105	19	β	β	NN
cord-301128-woe6knpv	105	20	ξ	ξ	VBZ
cord-301128-woe6knpv	105	21	the	the	DT
cord-301128-woe6knpv	105	22	angle	angle	NN
cord-301128-woe6knpv	105	23	formed	form	VBN
cord-301128-woe6knpv	105	24	by	by	IN
cord-301128-woe6knpv	105	25	beads	bead	NNS
cord-301128-woe6knpv	105	26	α	α	NNP
cord-301128-woe6knpv	105	27	,	,	,
cord-301128-woe6knpv	105	28	β	β	NN
cord-301128-woe6knpv	105	29	and	and	CC
cord-301128-woe6knpv	105	30	1	1	CD
cord-301128-woe6knpv	105	31	β	β	NN
cord-301128-woe6knpv	105	32	+	+	CC
cord-301128-woe6knpv	105	33	.	.	.
cord-301128-woe6knpv	106	1	Note	note	VB
cord-301128-woe6knpv	106	2	that	that	IN
cord-301128-woe6knpv	106	3	the	the	DT
cord-301128-woe6knpv	106	4	bending	bend	VBG
cord-301128-woe6knpv	106	5	rigidity	rigidity	NN
cord-301128-woe6knpv	106	6	for	for	IN
cord-301128-woe6knpv	106	7	these	these	DT
cord-301128-woe6knpv	106	8	two	two	CD
cord-301128-woe6knpv	106	9	angles	angle	NNS
cord-301128-woe6knpv	106	10	was	be	VBD
cord-301128-woe6knpv	106	11	assumed	assume	VBN
cord-301128-woe6knpv	106	12	to	to	TO
cord-301128-woe6knpv	106	13	be	be	VB
cord-301128-woe6knpv	106	14	five	five	CD
cord-301128-woe6knpv	106	15	time	time	NN
cord-301128-woe6knpv	106	16	larger	large	JJR
cord-301128-woe6knpv	106	17	than	than	IN
cord-301128-woe6knpv	106	18	the	the	DT
cord-301128-woe6knpv	106	19	bending	bend	VBG
cord-301128-woe6knpv	106	20	rigidity	rigidity	NN
cord-301128-woe6knpv	106	21	of	of	IN
cord-301128-woe6knpv	106	22	the	the	DT
cord-301128-woe6knpv	106	23	DNA	dna	NN
cord-301128-woe6knpv	106	24	chain	chain	NN
cord-301128-woe6knpv	106	25	,	,	,
cord-301128-woe6knpv	106	26	in	in	IN
cord-301128-woe6knpv	106	27	order	order	NN
cord-301128-woe6knpv	106	28	for	for	IN
cord-301128-woe6knpv	106	29	α	α	NNP
cord-301128-woe6knpv	106	30	ξ	ξ	NNP
cord-301128-woe6knpv	106	31	and	and	CC
cord-301128-woe6knpv	106	32	β	β	NN
cord-301128-woe6knpv	106	33	ξ	ξ	NN
cord-301128-woe6knpv	106	34	to	to	TO
cord-301128-woe6knpv	106	35	deviate	deviate	VB
cord-301128-woe6knpv	106	36	only	only	RB
cord-301128-woe6knpv	106	37	moderately	moderately	RB
cord-301128-woe6knpv	106	38	from	from	IN
cord-301128-woe6knpv	106	39	/	/	SYM
cord-301128-woe6knpv	106	40	2	2	CD
cord-301128-woe6knpv	107	1	π	π	NNP
cord-301128-woe6knpv	107	2	.	.	.
cord-301128-woe6knpv	108	1	In	in	IN
cord-301128-woe6knpv	108	2	this	this	DT
cord-301128-woe6knpv	108	3	second	second	JJ
cord-301128-woe6knpv	108	4	model	model	NN
cord-301128-woe6knpv	108	5	,	,	,
cord-301128-woe6knpv	108	6	the	the	DT
cord-301128-woe6knpv	108	7	action	action	NN
cord-301128-woe6knpv	108	8	of	of	IN
cord-301128-woe6knpv	108	9	DNA	dna	NN
cord-301128-woe6knpv	108	10	-	-	HYPH
cord-301128-woe6knpv	108	11	bridging	bridge	VBG
cord-301128-woe6knpv	108	12	proteins	protein	NNS
cord-301128-woe6knpv	108	13	is	be	VBZ
cord-301128-woe6knpv	108	14	consequently	consequently	RB
cord-301128-woe6knpv	108	15	modeled	model	VBN
cord-301128-woe6knpv	108	16	by	by	IN
cord-301128-woe6knpv	108	17	the	the	DT
cord-301128-woe6knpv	108	18	potential	potential	JJ
cord-301128-woe6knpv	108	19	energy	energy	NN
cord-301128-woe6knpv	108	20	terms	term	NNS
cord-301128-woe6knpv	108	21	in	in	IN
cord-301128-woe6knpv	108	22	Eq	Eq	NNP
cord-301128-woe6knpv	108	23	.	.	.
cord-301128-woe6knpv	109	1	Fig	Fig	NNP
cord-301128-woe6knpv	109	2	.	.	.
cord-301128-woe6knpv	109	3	4(b	4(b	CD
cord-301128-woe6knpv	109	4	)	)	-RRB-
cord-301128-woe6knpv	109	5	.	.	.
cord-301128-woe6knpv	110	1	It	-PRON-	PRP
cord-301128-woe6knpv	110	2	is	be	VBZ
cord-301128-woe6knpv	110	3	stressed	stress	VBN
cord-301128-woe6knpv	110	4	that	that	IN
cord-301128-woe6knpv	110	5	this	this	DT
cord-301128-woe6knpv	110	6	behavior	behavior	NN
cord-301128-woe6knpv	110	7	has	have	VBZ
cord-301128-woe6knpv	110	8	no	no	DT
cord-301128-woe6knpv	110	9	precise	precise	JJ
cord-301128-woe6knpv	110	10	physical	physical	JJ
cord-301128-woe6knpv	110	11	meaning	meaning	NN
cord-301128-woe6knpv	110	12	but	but	CC
cord-301128-woe6knpv	110	13	arises	arise	VBZ
cord-301128-woe6knpv	110	14	instead	instead	RB
cord-301128-woe6knpv	110	15	from	from	IN
cord-301128-woe6knpv	110	16	the	the	DT
cord-301128-woe6knpv	110	17	mathematical	mathematical	JJ
cord-301128-woe6knpv	110	18	definition	definition	NN
cord-301128-woe6knpv	110	19	of	of	IN
cord-301128-woe6knpv	110	20	the	the	DT
cord-301128-woe6knpv	110	21	total	total	NN
cord-301128-woe6knpv	110	22	writhe	writhe	NN
cord-301128-woe6knpv	110	23	r	r	NNP
cord-301128-woe6knpv	110	24	W	W	NNP
cord-301128-woe6knpv	110	25	in	in	IN
cord-301128-woe6knpv	110	26	Eq	Eq	NNP
cord-301128-woe6knpv	110	27	.	.	.
cord-301128-woe6knpv	111	1	(	(	-LRB-
cord-301128-woe6knpv	111	2	S11	S11	NNP
cord-301128-woe6knpv	111	3	)	)	-RRB-
cord-301128-woe6knpv	111	4	and	and	CC
cord-301128-woe6knpv	111	5	its	-PRON-	PRP$
cord-301128-woe6knpv	111	6	somewhat	somewhat	RB
cord-301128-woe6knpv	111	7	arbitrary	arbitrary	JJ
cord-301128-woe6knpv	111	8	partitioning	partitioning	NN
cord-301128-woe6knpv	111	9	into	into	IN
cord-301128-woe6knpv	111	10	the	the	DT
cord-301128-woe6knpv	111	11	sum	sum	NN
cord-301128-woe6knpv	111	12	of	of	IN
cord-301128-woe6knpv	111	13	the	the	DT
cord-301128-woe6knpv	111	14	two	two	CD
cord-301128-woe6knpv	111	15	partial	partial	JJ
cord-301128-woe6knpv	111	16	quantities	quantity	NNS
cord-301128-woe6knpv	111	17	r	r	NNP
cord-301128-woe6knpv	111	18	j	j	NNP
cord-301128-woe6knpv	111	19	W	W	NNP
cord-301128-woe6knpv	111	20	and	and	CC
cord-301128-woe6knpv	111	21	12	12	CD
cord-301128-woe6knpv	111	22	r	r	NN
cord-301128-woe6knpv	111	23	W	w	NN
cord-301128-woe6knpv	111	24	in	in	IN
cord-301128-woe6knpv	111	25	Eq	Eq	NNP
cord-301128-woe6knpv	111	26	.	.	.
cord-301128-woe6knpv	112	1	(	(	-LRB-
cord-301128-woe6knpv	112	2	S17	S17	NNP
cord-301128-woe6knpv	112	3	)	)	-RRB-
cord-301128-woe6knpv	112	4	.	.	.
cord-301128-woe6knpv	113	1	In	in	IN
cord-301128-woe6knpv	113	2	particular	particular	JJ
cord-301128-woe6knpv	113	3	,	,	,
cord-301128-woe6knpv	113	4	r	r	NNP
cord-301128-woe6knpv	113	5	W	W	NNP
cord-301128-woe6knpv	113	6	does	do	VBZ
cord-301128-woe6knpv	113	7	not	not	RB
cord-301128-woe6knpv	113	8	display	display	VB
cord-301128-woe6knpv	113	9	any	any	DT
cord-301128-woe6knpv	113	10	sharp	sharp	JJ
cord-301128-woe6knpv	113	11	jump	jump	NN
cord-301128-woe6knpv	113	12	along	along	IN
cord-301128-woe6knpv	113	13	single	single	JJ
cord-301128-woe6knpv	113	14	trajectories	trajectory	NNS
cord-301128-woe6knpv	113	15	.	.	.
cord-301128-woe6knpv	114	1	As	as	IN
cord-301128-woe6knpv	114	2	can	can	MD
cord-301128-woe6knpv	114	3	be	be	VB
cord-301128-woe6knpv	114	4	checked	check	VBN
cord-301128-woe6knpv	114	5	in	in	IN
cord-301128-woe6knpv	114	6	Fig	Fig	NNP
cord-301128-woe6knpv	114	7	.	.	.
cord-301128-woe6knpv	115	1	4	4	LS
cord-301128-woe6knpv	116	1	Fig	Fig	NNP
cord-301128-woe6knpv	116	2	.	.	.
cord-301128-woe6knpv	116	3	4(b	4(b	CD
cord-301128-woe6knpv	116	4	)	)	-RRB-
cord-301128-woe6knpv	116	5	)	)	-RRB-
cord-301128-woe6knpv	116	6	.	.	.
cord-301128-woe6knpv	117	1	According	accord	VBG
cord-301128-woe6knpv	117	2	to	to	IN
cord-301128-woe6knpv	117	3	Eq	Eq	NNP
cord-301128-woe6knpv	117	4	.	.	.
cord-301128-woe6knpv	118	1	(	(	-LRB-
cord-301128-woe6knpv	118	2	1	1	CD
cord-301128-woe6knpv	118	3	)	)	-RRB-
cord-301128-woe6knpv	118	4	,	,	,
cord-301128-woe6knpv	118	5	this	this	DT
cord-301128-woe6knpv	118	6	limit	limit	NN
cord-301128-woe6knpv	118	7	is	be	VBZ
cord-301128-woe6knpv	118	8	equivalent	equivalent	JJ
cord-301128-woe6knpv	118	9	to	to	IN
cord-301128-woe6knpv	118	10	12	12	CD
cord-301128-woe6knpv	118	11	r	r	NN
cord-301128-woe6knpv	118	12	r	r	NN
cord-301128-woe6knpv	118	13	W	w	NN
cord-301128-woe6knpv	118	14	W	w	NN
cord-301128-woe6knpv	118	15	=	=	SYM
cord-301128-woe6knpv	118	16	.	.	.
cord-301128-woe6knpv	118	17	)	)	-RRB-
cord-301128-woe6knpv	119	1	superimpose	superimpose	VB
cord-301128-woe6knpv	119	2	at	at	IN
cord-301128-woe6knpv	119	3	short	short	JJ
cord-301128-woe6knpv	119	4	times	time	NNS
cord-301128-woe6knpv	119	5	,	,	,
cord-301128-woe6knpv	119	6	which	which	WDT
cord-301128-woe6knpv	119	7	indicates	indicate	VBZ
cord-301128-woe6knpv	119	8	that	that	IN
cord-301128-woe6knpv	119	9	the	the	DT
cord-301128-woe6knpv	119	10	relaxation	relaxation	NN
cord-301128-woe6knpv	119	11	speed	speed	NN
cord-301128-woe6knpv	119	12	is	be	VBZ
cord-301128-woe6knpv	119	13	proportional	proportional	JJ
cord-301128-woe6knpv	119	14	to	to	IN
cord-301128-woe6knpv	119	15	the	the	DT
cord-301128-woe6knpv	119	16	total	total	JJ
cord-301128-woe6knpv	119	17	amount	amount	NN
cord-301128-woe6knpv	119	18	of	of	IN
cord-301128-woe6knpv	119	19	torsional	torsional	JJ
cord-301128-woe6knpv	119	20	stress	stress	NN
cord-301128-woe6knpv	119	21	.	.	.
cord-301128-woe6knpv	120	1	However	however	RB
cord-301128-woe6knpv	120	2	,	,	,
cord-301128-woe6knpv	120	3	for	for	IN
cord-301128-woe6knpv	120	4	longer	long	JJR
cord-301128-woe6knpv	120	5	times	time	NNS
cord-301128-woe6knpv	120	6	and/or	and/or	CC
cord-301128-woe6knpv	120	7	larger	large	JJR
cord-301128-woe6knpv	120	8	values	value	NNS
cord-301128-woe6knpv	120	9	of	of	IN
cord-301128-woe6knpv	120	10	the	the	DT
cord-301128-woe6knpv	120	11	linking	link	VBG
cord-301128-woe6knpv	120	12	number	number	NN
cord-301128-woe6knpv	120	13	difference	difference	NN
cord-301128-woe6knpv	120	14	,	,	,
cord-301128-woe6knpv	120	15	a	a	DT
cord-301128-woe6knpv	120	16	slower	slow	JJR
cord-301128-woe6knpv	120	17	regime	regime	NN
cord-301128-woe6knpv	120	18	sets	set	NNS
cord-301128-woe6knpv	120	19	in	in	RP
cord-301128-woe6knpv	120	20	,	,	,
cord-301128-woe6knpv	120	21	which	which	WDT
cord-301128-woe6knpv	120	22	is	be	VBZ
cord-301128-woe6knpv	120	23	probably	probably	RB
cord-301128-woe6knpv	120	24	due	due	JJ
cord-301128-woe6knpv	120	25	to	to	IN
cord-301128-woe6knpv	120	26	the	the	DT
cord-301128-woe6knpv	120	27	resistance	resistance	NN
cord-301128-woe6knpv	120	28	opposed	oppose	VBN
cord-301128-woe6knpv	120	29	by	by	IN
cord-301128-woe6knpv	120	30	plectonemes	plectoneme	NNS
cord-301128-woe6knpv	120	31	against	against	IN
cord-301128-woe6knpv	120	32	the	the	DT
cord-301128-woe6knpv	120	33	reorganization	reorganization	NN
cord-301128-woe6knpv	120	34	of	of	IN
cord-301128-woe6knpv	120	35	the	the	DT
cord-301128-woe6knpv	120	36	chain	chain	NN
cord-301128-woe6knpv	120	37	and	and	CC
cord-301128-woe6knpv	120	38	the	the	DT
cord-301128-woe6knpv	120	39	intrication	intrication	NN
cord-301128-woe6knpv	120	40	of	of	IN
cord-301128-woe6knpv	120	41	the	the	DT
cord-301128-woe6knpv	120	42	two	two	CD
cord-301128-woe6knpv	120	43	moieties	moiety	NNS
cord-301128-woe6knpv	120	44	.	.	.
cord-301128-woe6knpv	121	1	Finally	finally	RB
cord-301128-woe6knpv	121	2	,	,	,
cord-301128-woe6knpv	121	3	we	-PRON-	PRP
cord-301128-woe6knpv	121	4	note	note	VBP
cord-301128-woe6knpv	121	5	that	that	IN
cord-301128-woe6knpv	121	6	after	after	IN
cord-301128-woe6knpv	121	7	full	full	JJ
cord-301128-woe6knpv	121	8	relaxation	relaxation	NN
cord-301128-woe6knpv	121	9	the	the	DT
cord-301128-woe6knpv	121	10	writhe	writhe	NNP
cord-301128-woe6knpv	121	11	contribution	contribution	NN
cord-301128-woe6knpv	121	12	accounts	account	VBZ
cord-301128-woe6knpv	121	13	for	for	IN
cord-301128-woe6knpv	121	14	approximately	approximately	RB
cord-301128-woe6knpv	121	15	90	90	CD
cord-301128-woe6knpv	121	16	%	%	NN
cord-301128-woe6knpv	121	17	of	of	IN
cord-301128-woe6knpv	121	18	the	the	DT
cord-301128-woe6knpv	121	19	linking	link	VBG
cord-301128-woe6knpv	121	20	number	number	NN
cord-301128-woe6knpv	121	21	difference	difference	NN
cord-301128-woe6knpv	121	22	,	,	,
cord-301128-woe6knpv	121	23	which	which	WDT
cord-301128-woe6knpv	121	24	is	be	VBZ
cord-301128-woe6knpv	121	25	significantly	significantly	RB
cord-301128-woe6knpv	121	26	larger	large	JJR
cord-301128-woe6knpv	121	27	than	than	IN
cord-301128-woe6knpv	121	28	the	the	DT
cord-301128-woe6knpv	121	29	70	70	CD
cord-301128-woe6knpv	121	30	%	%	NN
cord-301128-woe6knpv	121	31	contribution	contribution	NN
cord-301128-woe6knpv	121	32	in	in	IN
cord-301128-woe6knpv	121	33	the	the	DT
cord-301128-woe6knpv	121	34	absence	absence	NN
cord-301128-woe6knpv	121	35	of	of	IN
cord-301128-woe6knpv	121	36	domains	domain	NNS
cord-301128-woe6knpv	121	37	(	(	-LRB-
cord-301128-woe6knpv	121	38	see	see	VB
cord-301128-woe6knpv	121	39	Fig	Fig	NNP
cord-301128-woe6knpv	121	40	.	.	.
cord-301128-woe6knpv	121	41	S1	S1	NNP
cord-301128-woe6knpv	121	42	)	)	-RRB-
cord-301128-woe6knpv	121	43	.	.	.
cord-301128-woe6knpv	122	1	In	in	IN
cord-301128-woe6knpv	122	2	conclusion	conclusion	NN
cord-301128-woe6knpv	122	3	,	,	,
cord-301128-woe6knpv	122	4	this	this	DT
cord-301128-woe6knpv	122	5	second	second	JJ
cord-301128-woe6knpv	122	6	model	model	NN
cord-301128-woe6knpv	122	7	of	of	IN
cord-301128-woe6knpv	122	8	DNA	dna	NN
cord-301128-woe6knpv	122	9	-	-	HYPH
cord-301128-woe6knpv	122	10	bridging	bridge	VBG
cord-301128-woe6knpv	122	11	proteins	protein	NNS
cord-301128-woe6knpv	122	12	indicates	indicate	VBZ
cord-301128-woe6knpv	122	13	that	that	IN
cord-301128-woe6knpv	122	14	blocking	block	VBG
cord-301128-woe6knpv	122	15	the	the	DT
cord-301128-woe6knpv	122	16	diffusion	diffusion	NN
cord-301128-woe6knpv	122	17	of	of	IN
cord-301128-woe6knpv	122	18	the	the	DT
cord-301128-woe6knpv	122	19	excess	excess	NN
cord-301128-woe6knpv	122	20	of	of	IN
cord-301128-woe6knpv	122	21	twist	twist	NN
cord-301128-woe6knpv	122	22	at	at	IN
cord-301128-woe6knpv	122	23	the	the	DT
cord-301128-woe6knpv	122	24	two	two	CD
cord-301128-woe6knpv	122	25	DNA	dna	NN
cord-301128-woe6knpv	122	26	loci	locus	NNS
cord-301128-woe6knpv	122	27	bound	bind	VBN
cord-301128-woe6knpv	122	28	by	by	IN
cord-301128-woe6knpv	122	29	the	the	DT
cord-301128-woe6knpv	122	30	proteins	protein	NNS
cord-301128-woe6knpv	122	31	is	be	VBZ
cord-301128-woe6knpv	122	32	sufficient	sufficient	JJ
cord-301128-woe6knpv	122	33	to	to	TO
cord-301128-woe6knpv	122	34	maintain	maintain	VB
cord-301128-woe6knpv	122	35	a	a	DT
cord-301128-woe6knpv	122	36	constant	constant	JJ
cord-301128-woe6knpv	122	37	difference	difference	NN
cord-301128-woe6knpv	122	38	between	between	IN
cord-301128-woe6knpv	122	39	the	the	DT
cord-301128-woe6knpv	122	40	linking	link	VBG
cord-301128-woe6knpv	122	41	number	number	NN
cord-301128-woe6knpv	122	42	difference	difference	NN
cord-301128-woe6knpv	122	43	,	,	,
cord-301128-woe6knpv	122	44	excess	excess	NN
cord-301128-woe6knpv	122	45	of	of	IN
cord-301128-woe6knpv	122	46	twist	twist	NN
cord-301128-woe6knpv	122	47	,	,	,
cord-301128-woe6knpv	122	48	and	and	CC
cord-301128-woe6knpv	122	49	writhe	writhe	NN
cord-301128-woe6knpv	122	50	of	of	IN
cord-301128-woe6knpv	122	51	the	the	DT
cord-301128-woe6knpv	122	52	two	two	CD
cord-301128-woe6knpv	122	53	moieties	moiety	NNS
cord-301128-woe6knpv	122	54	,	,	,
cord-301128-woe6knpv	122	55	but	but	CC
cord-301128-woe6knpv	122	56	that	that	IN
cord-301128-woe6knpv	122	57	it	-PRON-	PRP
cord-301128-woe6knpv	122	58	is	be	VBZ
cord-301128-woe6knpv	122	59	not	not	RB
cord-301128-woe6knpv	122	60	sufficient	sufficient	JJ
cord-301128-woe6knpv	122	61	to	to	TO
cord-301128-woe6knpv	122	62	insure	insure	VB
cord-301128-woe6knpv	122	63	true	true	JJ
cord-301128-woe6knpv	122	64	topological	topological	JJ
cord-301128-woe6knpv	122	65	independence	independence	NN
cord-301128-woe6knpv	122	66	.	.	.
cord-301128-woe6knpv	123	1	Indeed	indeed	RB
cord-301128-woe6knpv	123	2	,	,	,
cord-301128-woe6knpv	123	3	the	the	DT
cord-301128-woe6knpv	123	4	DNA	dna	NN
cord-301128-woe6knpv	123	5	chain	chain	NN
cord-301128-woe6knpv	123	6	evolves	evolve	VBZ
cord-301128-woe6knpv	123	7	towards	towards	IN
cord-301128-woe6knpv	123	8	very	very	RB
cord-301128-woe6knpv	123	9	compact	compact	JJ
cord-301128-woe6knpv	123	10	and	and	CC
cord-301128-woe6knpv	123	11	intricated	intricated	JJ
cord-301128-woe6knpv	123	12	final	final	JJ
cord-301128-woe6knpv	123	13	conformations	conformation	NNS
cord-301128-woe6knpv	123	14	,	,	,
cord-301128-woe6knpv	123	15	where	where	WRB
cord-301128-woe6knpv	123	16	the	the	DT
cord-301128-woe6knpv	123	17	topology	topology	NN
cord-301128-woe6knpv	123	18	of	of	IN
cord-301128-woe6knpv	123	19	each	each	DT
cord-301128-woe6knpv	123	20	moiety	moiety	NN
cord-301128-woe6knpv	123	21	is	be	VBZ
cord-301128-woe6knpv	123	22	different	different	JJ
cord-301128-woe6knpv	123	23	from	from	IN
cord-301128-woe6knpv	123	24	the	the	DT
cord-301128-woe6knpv	123	25	initial	initial	JJ
cord-301128-woe6knpv	123	26	one	one	CD
cord-301128-woe6knpv	123	27	.	.	.
cord-301128-woe6knpv	124	1	The	the	DT
cord-301128-woe6knpv	124	2	relaxation	relaxation	NN
cord-301128-woe6knpv	124	3	limit	limit	NN
cord-301128-woe6knpv	124	4	12	12	CD
cord-301128-woe6knpv	124	5	r	r	NN
cord-301128-woe6knpv	124	6	r	r	NN
cord-301128-woe6knpv	124	7	W	w	NN
cord-301128-woe6knpv	124	8	W	w	NN
cord-301128-woe6knpv	124	9	=	=	SYM
cord-301128-woe6knpv	124	10	(	(	-LRB-
cord-301128-woe6knpv	124	11	or	or	CC
cord-301128-woe6knpv	124	12	equivalently	equivalently	RB
cord-301128-woe6knpv	124	13	1	1	CD
cord-301128-woe6knpv	124	14	2	2	CD
cord-301128-woe6knpv	124	15	r	r	NN
cord-301128-woe6knpv	124	16	r	r	NN
cord-301128-woe6knpv	124	17	0	0	CD
cord-301128-woe6knpv	124	18	W	w	NN
cord-301128-woe6knpv	124	19	W	w	NN
cord-301128-woe6knpv	125	1	+	+	CC
cord-301128-woe6knpv	125	2	=	=	SYM
cord-301128-woe6knpv	125	3	)	)	-RRB-
cord-301128-woe6knpv	125	4	appears	appear	VBZ
cord-301128-woe6knpv	125	5	non	non	AFX
cord-301128-woe6knpv	125	6	trivial	trivial	JJ
cord-301128-woe6knpv	125	7	and	and	CC
cord-301128-woe6knpv	125	8	intriguing	intriguing	JJ
cord-301128-woe6knpv	125	9	to	to	IN
cord-301128-woe6knpv	125	10	us	-PRON-	PRP
cord-301128-woe6knpv	125	11	.	.	.
cord-301128-woe6knpv	126	1	We	-PRON-	PRP
cord-301128-woe6knpv	126	2	suspect	suspect	VBP
cord-301128-woe6knpv	126	3	that	that	IN
cord-301128-woe6knpv	126	4	the	the	DT
cord-301128-woe6knpv	126	5	explanation	explanation	NN
cord-301128-woe6knpv	126	6	involves	involve	VBZ
cord-301128-woe6knpv	126	7	subtle	subtle	JJ
cord-301128-woe6knpv	126	8	considerations	consideration	NNS
cord-301128-woe6knpv	126	9	that	that	WDT
cord-301128-woe6knpv	126	10	should	should	MD
cord-301128-woe6knpv	126	11	deserve	deserve	VB
cord-301128-woe6knpv	126	12	further	further	JJ
cord-301128-woe6knpv	126	13	work	work	NN
cord-301128-woe6knpv	126	14	.	.	.
cord-301128-woe6knpv	127	1	The	the	DT
cord-301128-woe6knpv	127	2	question	question	NN
cord-301128-woe6knpv	127	3	that	that	WDT
cord-301128-woe6knpv	127	4	remains	remain	VBZ
cord-301128-woe6knpv	127	5	to	to	TO
cord-301128-woe6knpv	127	6	be	be	VB
cord-301128-woe6knpv	127	7	answered	answer	VBN
cord-301128-woe6knpv	127	8	is	be	VBZ
cord-301128-woe6knpv	127	9	consequently	consequently	RB
cord-301128-woe6knpv	127	10	:	:	:
cord-301128-woe6knpv	127	11	What	what	WP
cord-301128-woe6knpv	127	12	additional	additional	JJ
cord-301128-woe6knpv	127	13	constraint	constraint	NN
cord-301128-woe6knpv	127	14	must	must	MD
cord-301128-woe6knpv	127	15	the	the	DT
cord-301128-woe6knpv	127	16	DNA	dna	NN
cord-301128-woe6knpv	127	17	-	-	HYPH
cord-301128-woe6knpv	127	18	bridging	bridge	VBG
cord-301128-woe6knpv	127	19	protein	protein	NN
cord-301128-woe6knpv	127	20	exert	exert	VBP
cord-301128-woe6knpv	127	21	on	on	IN
cord-301128-woe6knpv	127	22	its	-PRON-	PRP$
cord-301128-woe6knpv	127	23	binding	bind	VBG
cord-301128-woe6knpv	127	24	sites	site	NNS
cord-301128-woe6knpv	127	25	in	in	IN
cord-301128-woe6knpv	127	26	order	order	NN
cord-301128-woe6knpv	127	27	to	to	TO
cord-301128-woe6knpv	127	28	preserve	preserve	VB
cord-301128-woe6knpv	127	29	not	not	RB
cord-301128-woe6knpv	127	30	only	only	RB
cord-301128-woe6knpv	127	31	the	the	DT
cord-301128-woe6knpv	127	32	difference	difference	NN
cord-301128-woe6knpv	127	33	in	in	IN
cord-301128-woe6knpv	127	34	torsional	torsional	JJ
cord-301128-woe6knpv	127	35	stress	stress	NN
cord-301128-woe6knpv	127	36	between	between	IN
cord-301128-woe6knpv	127	37	the	the	DT
cord-301128-woe6knpv	127	38	two	two	CD
cord-301128-woe6knpv	127	39	moieties	moiety	NNS
cord-301128-woe6knpv	127	40	of	of	IN
cord-301128-woe6knpv	127	41	the	the	DT
cord-301128-woe6knpv	127	42	DNA	dna	NN
cord-301128-woe6knpv	127	43	chain	chain	NN
cord-301128-woe6knpv	127	44	,	,	,
cord-301128-woe6knpv	127	45	but	but	CC
cord-301128-woe6knpv	127	46	rather	rather	RB
cord-301128-woe6knpv	127	47	the	the	DT
cord-301128-woe6knpv	127	48	precise	precise	JJ
cord-301128-woe6knpv	127	49	initial	initial	JJ
cord-301128-woe6knpv	127	50	torsional	torsional	JJ
cord-301128-woe6knpv	127	51	stress	stress	NN
cord-301128-woe6knpv	127	52	in	in	IN
cord-301128-woe6knpv	127	53	each	each	DT
cord-301128-woe6knpv	127	54	moiety	moiety	NN
cord-301128-woe6knpv	127	55	?	?	.
cord-301128-woe6knpv	128	1	The	the	DT
cord-301128-woe6knpv	128	2	feeling	feeling	NN
cord-301128-woe6knpv	128	3	that	that	WDT
cord-301128-woe6knpv	128	4	emerges	emerge	VBZ
cord-301128-woe6knpv	128	5	upon	upon	IN
cord-301128-woe6knpv	128	6	examination	examination	NN
cord-301128-woe6knpv	128	7	of	of	IN
cord-301128-woe6knpv	128	8	conformations	conformation	NNS
cord-301128-woe6knpv	128	9	like	like	IN
cord-301128-woe6knpv	128	10	the	the	DT
cord-301128-woe6knpv	128	11	one	one	CD
cord-301128-woe6knpv	128	12	shown	show	VBN
cord-301128-woe6knpv	128	13	in	in	IN
cord-301128-woe6knpv	128	14	Fig	Fig	NNP
cord-301128-woe6knpv	128	15	.	.	.
cord-301128-woe6knpv	128	16	3(b	3(b	CD
cord-301128-woe6knpv	128	17	)	)	-RRB-
cord-301128-woe6knpv	128	18	,	,	,
cord-301128-woe6knpv	128	19	is	be	VBZ
cord-301128-woe6knpv	128	20	that	that	IN
cord-301128-woe6knpv	128	21	the	the	DT
cord-301128-woe6knpv	128	22	winding	winding	NN
cord-301128-woe6knpv	128	23	of	of	IN
cord-301128-woe6knpv	128	24	the	the	DT
cord-301128-woe6knpv	128	25	initially	initially	RB
cord-301128-woe6knpv	128	26	relaxed	relaxed	JJ
cord-301128-woe6knpv	128	27	moiety	moiety	NN
cord-301128-woe6knpv	128	28	around	around	IN
cord-301128-woe6knpv	128	29	the	the	DT
cord-301128-woe6knpv	128	30	initially	initially	RB
cord-301128-woe6knpv	128	31	stressed	stress	VBN
cord-301128-woe6knpv	128	32	one	one	CD
cord-301128-woe6knpv	128	33	probably	probably	RB
cord-301128-woe6knpv	128	34	requires	require	VBZ
cord-301128-woe6knpv	128	35	the	the	DT
cord-301128-woe6knpv	128	36	relative	relative	JJ
cord-301128-woe6knpv	128	37	rotation	rotation	NN
cord-301128-woe6knpv	128	38	of	of	IN
cord-301128-woe6knpv	128	39	the	the	DT
cord-301128-woe6knpv	128	40	two	two	CD
cord-301128-woe6knpv	128	41	DNA	dna	NN
cord-301128-woe6knpv	128	42	segments	segment	NNS
cord-301128-woe6knpv	128	43	around	around	IN
cord-301128-woe6knpv	128	44	the	the	DT
cord-301128-woe6knpv	128	45	αβ	αβ	NNP
cord-301128-woe6knpv	128	46	bond	bond	NN
cord-301128-woe6knpv	128	47	,	,	,
cord-301128-woe6knpv	128	48	and	and	CC
cord-301128-woe6knpv	128	49	that	that	IN
cord-301128-woe6knpv	128	50	no	no	DT
cord-301128-woe6knpv	128	51	winding	winding	NN
cord-301128-woe6knpv	128	52	would	would	MD
cord-301128-woe6knpv	128	53	be	be	VB
cord-301128-woe6knpv	128	54	possible	possible	JJ
cord-301128-woe6knpv	128	55	if	if	IN
cord-301128-woe6knpv	128	56	this	this	DT
cord-301128-woe6knpv	128	57	rotation	rotation	NN
cord-301128-woe6knpv	128	58	were	be	VBD
cord-301128-woe6knpv	128	59	blocked	block	VBN
cord-301128-woe6knpv	128	60	.	.	.
cord-301128-woe6knpv	129	1	In	in	IN
cord-301128-woe6knpv	129	2	order	order	NN
cord-301128-woe6knpv	129	3	to	to	TO
cord-301128-woe6knpv	129	4	check	check	VB
cord-301128-woe6knpv	129	5	this	this	DT
cord-301128-woe6knpv	129	6	conjecture	conjecture	NN
cord-301128-woe6knpv	129	7	,	,	,
cord-301128-woe6knpv	129	8	a	a	DT
cord-301128-woe6knpv	129	9	third	third	JJ
cord-301128-woe6knpv	129	10	bending	bend	VBG
cord-301128-woe6knpv	129	11	term	term	NN
cord-301128-woe6knpv	129	12	was	be	VBD
cord-301128-woe6knpv	129	13	added	add	VBN
cord-301128-woe6knpv	129	14	to	to	IN
cord-301128-woe6knpv	129	15	BP	BP	NNP
cord-301128-woe6knpv	129	16	E	E	NNP
cord-301128-woe6knpv	129	17	,	,	,
cord-301128-woe6knpv	129	18	namely	namely	RB
cord-301128-woe6knpv	129	19	0	0	CD
cord-301128-woe6knpv	129	20	2	2	CD
cord-301128-woe6knpv	129	21	2	2	CD
cord-301128-woe6knpv	129	22	2	2	CD
cord-301128-woe6knpv	129	23	0	0	CD
cord-301128-woe6knpv	129	24	2	2	CD
cord-301128-woe6knpv	129	25	BP	BP	NNP
cord-301128-woe6knpv	129	26	,	,	,
cord-301128-woe6knpv	129	27	,	,	,
cord-301128-woe6knpv	129	28	16	16	CD
cord-301128-woe6knpv	129	29	)	)	-RRB-
cord-301128-woe6knpv	129	30	.	.	.
cord-301128-woe6knpv	130	1	In	in	IN
cord-301128-woe6knpv	130	2	this	this	DT
cord-301128-woe6knpv	130	3	context	context	NN
cord-301128-woe6knpv	130	4	,	,	,
cord-301128-woe6knpv	130	5	we	-PRON-	PRP
cord-301128-woe6knpv	130	6	surmise	surmise	VBP
cord-301128-woe6knpv	130	7	that	that	IN
cord-301128-woe6knpv	130	8	the	the	DT
cord-301128-woe6knpv	130	9	slow	slow	JJ
cord-301128-woe6knpv	130	10	relaxation	relaxation	NN
cord-301128-woe6knpv	130	11	observed	observe	VBN
cord-301128-woe6knpv	130	12	in	in	IN
cord-301128-woe6knpv	130	13	(	(	-LRB-
cord-301128-woe6knpv	130	14	15	15	CD
cord-301128-woe6knpv	130	15	)	)	-RRB-
cord-301128-woe6knpv	130	16	for	for	IN
cord-301128-woe6knpv	130	17	single	single	JJ
cord-301128-woe6knpv	130	18	DNA	dna	NN
cord-301128-woe6knpv	130	19	-	-	HYPH
cord-301128-woe6knpv	130	20	bridges	bridge	NNS
cord-301128-woe6knpv	130	21	may	may	MD
cord-301128-woe6knpv	130	22	correspond	correspond	VB
cord-301128-woe6knpv	130	23	to	to	IN
cord-301128-woe6knpv	130	24	the	the	DT
cord-301128-woe6knpv	130	25	slow	slow	JJ
cord-301128-woe6knpv	130	26	intrication	intrication	NN
cord-301128-woe6knpv	130	27	obtained	obtain	VBN
cord-301128-woe6knpv	130	28	with	with	IN
cord-301128-woe6knpv	130	29	our	-PRON-	PRP$
cord-301128-woe6knpv	130	30	second	second	JJ
cord-301128-woe6knpv	130	31	model	model	NN
cord-301128-woe6knpv	130	32	for	for	IN
cord-301128-woe6knpv	130	33	DNA	dna	NN
cord-301128-woe6knpv	130	34	-	-	HYPH
cord-301128-woe6knpv	130	35	bridging	bridge	VBG
cord-301128-woe6knpv	130	36	proteins	protein	NNS
cord-301128-woe6knpv	130	37	,	,	,
cord-301128-woe6knpv	130	38	while	while	IN
cord-301128-woe6knpv	130	39	the	the	DT
cord-301128-woe6knpv	130	40	more	more	RBR
cord-301128-woe6knpv	130	41	stable	stable	JJ
cord-301128-woe6knpv	130	42	topological	topological	JJ
cord-301128-woe6knpv	130	43	separation	separation	NN
cord-301128-woe6knpv	130	44	observed	observe	VBN
cord-301128-woe6knpv	130	45	in	in	IN
cord-301128-woe6knpv	130	46	(	(	-LRB-
cord-301128-woe6knpv	130	47	15	15	CD
cord-301128-woe6knpv	130	48	)	)	-RRB-
cord-301128-woe6knpv	130	49	for	for	IN
cord-301128-woe6knpv	130	50	bridges	bridge	NNS
cord-301128-woe6knpv	130	51	in	in	IN
cord-301128-woe6knpv	130	52	tandem	tandem	NN
cord-301128-woe6knpv	130	53	corresponds	correspond	NNS
cord-301128-woe6knpv	130	54	to	to	IN
cord-301128-woe6knpv	130	55	true	true	JJ
cord-301128-woe6knpv	130	56	barriers	barrier	NNS
cord-301128-woe6knpv	130	57	obtained	obtain	VBN
cord-301128-woe6knpv	130	58	with	with	IN
cord-301128-woe6knpv	130	59	the	the	DT
cord-301128-woe6knpv	130	60	third	third	JJ
cord-301128-woe6knpv	130	61	model	model	NN
cord-301128-woe6knpv	130	62	for	for	IN
cord-301128-woe6knpv	130	63	DNA	dna	NN
cord-301128-woe6knpv	130	64	-	-	HYPH
cord-301128-woe6knpv	130	65	bridging	bridge	VBG
cord-301128-woe6knpv	130	66	proteins	protein	NNS
cord-301128-woe6knpv	130	67	.	.	.
cord-301128-woe6knpv	131	1	We	-PRON-	PRP
cord-301128-woe6knpv	131	2	finally	finally	RB
cord-301128-woe6knpv	131	3	note	note	VBP
cord-301128-woe6knpv	131	4	that	that	IN
cord-301128-woe6knpv	131	5	the	the	DT
cord-301128-woe6knpv	131	6	intrication	intrication	NN
cord-301128-woe6knpv	131	7	properties	property	NNS
cord-301128-woe6knpv	131	8	discussed	discuss	VBN
cord-301128-woe6knpv	131	9	here	here	RB
cord-301128-woe6knpv	131	10	are	be	VBP
cord-301128-woe6knpv	131	11	also	also	RB
cord-301128-woe6knpv	131	12	expected	expect	VBN
cord-301128-woe6knpv	131	13	to	to	TO
cord-301128-woe6knpv	131	14	contribute	contribute	VB
cord-301128-woe6knpv	131	15	to	to	IN
cord-301128-woe6knpv	131	16	the	the	DT
cord-301128-woe6knpv	131	17	formation	formation	NN
cord-301128-woe6knpv	131	18	of	of	IN
cord-301128-woe6knpv	131	19	topological	topological	JJ
cord-301128-woe6knpv	131	20	domains	domain	NNS
cord-301128-woe6knpv	131	21	that	that	WDT
cord-301128-woe6knpv	131	22	are	be	VBP
cord-301128-woe6knpv	131	23	,	,	,
cord-301128-woe6knpv	131	24	in	in	IN
cord-301128-woe6knpv	131	25	effect	effect	NN
cord-301128-woe6knpv	131	26	,	,	,
cord-301128-woe6knpv	131	27	larger	large	JJR
cord-301128-woe6knpv	131	28	than	than	IN
cord-301128-woe6knpv	131	29	the	the	DT
cord-301128-woe6knpv	131	30	domain	domain	NN
cord-301128-woe6knpv	131	31	delineated	delineate	VBN
cord-301128-woe6knpv	131	32	by	by	IN
cord-301128-woe6knpv	131	33	the	the	DT
cord-301128-woe6knpv	131	34	binding	bind	VBG
cord-301128-woe6knpv	131	35	sites	site	NNS
cord-301128-woe6knpv	131	36	of	of	IN
cord-301128-woe6knpv	131	37	LacI	LacI	NNP
cord-301128-woe6knpv	131	38	as	as	IN
cord-301128-woe6knpv	131	39	recently	recently	RB
cord-301128-woe6knpv	131	40	observed	observe	VBN
cord-301128-woe6knpv	131	41	in	in	IN
cord-301128-woe6knpv	131	42	(	(	-LRB-
cord-301128-woe6knpv	131	43	16	16	CD
cord-301128-woe6knpv	131	44	)	)	-RRB-
cord-301128-woe6knpv	131	45	.	.	.
cord-301128-woe6knpv	132	1	DNA	dna	NN
cord-301128-woe6knpv	132	2	-	-	HYPH
cord-301128-woe6knpv	132	3	bridging	bridge	VBG
cord-301128-woe6knpv	132	4	proteins	protein	NNS
cord-301128-woe6knpv	132	5	form	form	VBP
cord-301128-woe6knpv	132	6	DNA	dna	NN
cord-301128-woe6knpv	132	7	loops	loop	NNS
cord-301128-woe6knpv	132	8	by	by	IN
cord-301128-woe6knpv	132	9	dynamically	dynamically	RB
cord-301128-woe6knpv	132	10	cross	cross	JJ
cord-301128-woe6knpv	132	11	-	-	JJ
cord-301128-woe6knpv	132	12	linking	link	VBG
cord-301128-woe6knpv	132	13	DNA	dna	NN
cord-301128-woe6knpv	132	14	sites	site	NNS
cord-301128-woe6knpv	132	15	that	that	WDT
cord-301128-woe6knpv	132	16	are	be	VBP
cord-301128-woe6knpv	132	17	widely	widely	RB
cord-301128-woe6knpv	132	18	separated	separate	VBN
cord-301128-woe6knpv	132	19	from	from	IN
cord-301128-woe6knpv	132	20	the	the	DT
cord-301128-woe6knpv	132	21	genomic	genomic	JJ
cord-301128-woe6knpv	132	22	point	point	NN
cord-301128-woe6knpv	132	23	of	of	IN
cord-301128-woe6knpv	132	24	view	view	NN
cord-301128-woe6knpv	132	25	(	(	-LRB-
cord-301128-woe6knpv	132	26	17	17	CD
cord-301128-woe6knpv	132	27	)	)	-RRB-
cord-301128-woe6knpv	132	28	(	(	-LRB-
cord-301128-woe6knpv	132	29	18	18	CD
cord-301128-woe6knpv	132	30	)	)	-RRB-
cord-301128-woe6knpv	132	31	(	(	-LRB-
cord-301128-woe6knpv	132	32	19	19	CD
cord-301128-woe6knpv	132	33	)	)	-RRB-
cord-301128-woe6knpv	132	34	(	(	-LRB-
cord-301128-woe6knpv	132	35	20	20	CD
cord-301128-woe6knpv	132	36	)	)	-RRB-
cord-301128-woe6knpv	132	37	(	(	-LRB-
cord-301128-woe6knpv	132	38	21	21	CD
cord-301128-woe6knpv	132	39	)	)	-RRB-
cord-301128-woe6knpv	132	40	(	(	-LRB-
cord-301128-woe6knpv	132	41	22	22	CD
cord-301128-woe6knpv	132	42	)	)	-RRB-
cord-301128-woe6knpv	132	43	.	.	.
cord-301128-woe6knpv	133	1	They	-PRON-	PRP
cord-301128-woe6knpv	133	2	usually	usually	RB
cord-301128-woe6knpv	133	3	bind	bind	VBP
cord-301128-woe6knpv	133	4	DNA	dna	NN
cord-301128-woe6knpv	133	5	nonspecifically	nonspecifically	RB
cord-301128-woe6knpv	133	6	but	but	CC
cord-301128-woe6knpv	133	7	with	with	IN
cord-301128-woe6knpv	133	8	high	high	JJ
cord-301128-woe6knpv	133	9	affinity	affinity	NN
cord-301128-woe6knpv	133	10	.	.	.
cord-301128-woe6knpv	134	1	DNA	dna	NN
cord-301128-woe6knpv	134	2	-	-	HYPH
cord-301128-woe6knpv	134	3	bridging	bridge	VBG
cord-301128-woe6knpv	134	4	proteins	protein	NNS
cord-301128-woe6knpv	134	5	have	have	VBP
cord-301128-woe6knpv	134	6	now	now	RB
cord-301128-woe6knpv	134	7	been	be	VBN
cord-301128-woe6knpv	134	8	investigated	investigate	VBN
cord-301128-woe6knpv	134	9	for	for	IN
cord-301128-woe6knpv	134	10	more	more	JJR
cord-301128-woe6knpv	134	11	than	than	IN
cord-301128-woe6knpv	134	12	two	two	CD
cord-301128-woe6knpv	134	13	decades	decade	NNS
cord-301128-woe6knpv	134	14	,	,	,
cord-301128-woe6knpv	134	15	but	but	CC
cord-301128-woe6knpv	134	16	it	-PRON-	PRP
cord-301128-woe6knpv	134	17	is	be	VBZ
cord-301128-woe6knpv	134	18	only	only	RB
cord-301128-woe6knpv	134	19	very	very	RB
cord-301128-woe6knpv	134	20	recently	recently	RB
cord-301128-woe6knpv	134	21	that	that	IN
cord-301128-woe6knpv	134	22	it	-PRON-	PRP
cord-301128-woe6knpv	134	23	has	have	VBZ
cord-301128-woe6knpv	134	24	been	be	VBN
cord-301128-woe6knpv	134	25	demonstrated	demonstrate	VBN
cord-301128-woe6knpv	134	26	that	that	IN
cord-301128-woe6knpv	134	27	a	a	DT
cord-301128-woe6knpv	134	28	DNAbridging	dnabridging	NN
cord-301128-woe6knpv	134	29	protein	protein	NN
cord-301128-woe6knpv	134	30	like	like	IN
cord-301128-woe6knpv	134	31	the	the	DT
cord-301128-woe6knpv	134	32	LacI	LacI	NNP
cord-301128-woe6knpv	134	33	repressor	repressor	NN
cord-301128-woe6knpv	134	34	is	be	VBZ
cord-301128-woe6knpv	134	35	able	able	JJ
cord-301128-woe6knpv	134	36	to	to	TO
cord-301128-woe6knpv	134	37	separate	separate	VB
cord-301128-woe6knpv	134	38	circular	circular	JJ
cord-301128-woe6knpv	134	39	plasmids	plasmid	NNS
cord-301128-woe6knpv	134	40	into	into	IN
cord-301128-woe6knpv	134	41	two	two	CD
cord-301128-woe6knpv	134	42	topologically	topologically	RB
cord-301128-woe6knpv	134	43	independent	independent	JJ
cord-301128-woe6knpv	134	44	loops	loop	NNS
cord-301128-woe6knpv	134	45	(	(	-LRB-
cord-301128-woe6knpv	134	46	15	15	CD
cord-301128-woe6knpv	134	47	,	,	,
cord-301128-woe6knpv	134	48	23	23	CD
cord-301128-woe6knpv	134	49	,	,	,
cord-301128-woe6knpv	134	50	24	24	CD
cord-301128-woe6knpv	134	51	)	)	-RRB-
cord-301128-woe6knpv	134	52	.	.	.
cord-301128-woe6knpv	135	1	To	to	IN
cord-301128-woe6knpv	135	2	the	the	DT
cord-301128-woe6knpv	135	3	best	good	JJS
cord-301128-woe6knpv	135	4	of	of	IN
cord-301128-woe6knpv	135	5	our	-PRON-	PRP$
cord-301128-woe6knpv	135	6	knowledge	knowledge	NN
cord-301128-woe6knpv	135	7	,	,	,
cord-301128-woe6knpv	135	8	this	this	DT
cord-301128-woe6knpv	135	9	is	be	VBZ
cord-301128-woe6knpv	135	10	at	at	IN
cord-301128-woe6knpv	135	11	present	present	JJ
cord-301128-woe6knpv	135	12	the	the	DT
cord-301128-woe6knpv	135	13	only	only	RB
cord-301128-woe6knpv	135	14	demonstrated	demonstrate	VBN
cord-301128-woe6knpv	135	15	case	case	NN
cord-301128-woe6knpv	135	16	of	of	IN
cord-301128-woe6knpv	135	17	a	a	DT
cord-301128-woe6knpv	135	18	DNA	dna	NN
cord-301128-woe6knpv	135	19	-	-	HYPH
cord-301128-woe6knpv	135	20	bridging	bridge	VBG
cord-301128-woe6knpv	135	21	protein	protein	NN
cord-301128-woe6knpv	135	22	acting	act	VBG
cord-301128-woe6knpv	135	23	as	as	IN
cord-301128-woe6knpv	135	24	a	a	DT
cord-301128-woe6knpv	135	25	topological	topological	JJ
cord-301128-woe6knpv	135	26	barrier	barrier	NN
cord-301128-woe6knpv	135	27	.	.	.
cord-301128-woe6knpv	136	1	In	in	IN
cord-301128-woe6knpv	136	2	the	the	DT
cord-301128-woe6knpv	136	3	present	present	JJ
cord-301128-woe6knpv	136	4	work	work	NN
cord-301128-woe6knpv	136	5	,	,	,
cord-301128-woe6knpv	136	6	we	-PRON-	PRP
cord-301128-woe6knpv	136	7	aimed	aim	VBD
cord-301128-woe6knpv	136	8	at	at	IN
cord-301128-woe6knpv	136	9	going	go	VBG
cord-301128-woe6knpv	136	10	one	one	CD
cord-301128-woe6knpv	136	11	step	step	NN
cord-301128-woe6knpv	136	12	further	far	RBR
cord-301128-woe6knpv	136	13	and	and	CC
cord-301128-woe6knpv	136	14	determining	determine	VBG
cord-301128-woe6knpv	136	15	the	the	DT
cord-301128-woe6knpv	136	16	conditions	condition	NNS
cord-301128-woe6knpv	136	17	that	that	WDT
cord-301128-woe6knpv	136	18	DNAbridging	dnabridge	VBG
cord-301128-woe6knpv	136	19	proteins	protein	NNS
cord-301128-woe6knpv	136	20	must	must	MD
cord-301128-woe6knpv	136	21	fulfill	fulfill	VB
cord-301128-woe6knpv	136	22	to	to	TO
cord-301128-woe6knpv	136	23	act	act	VB
cord-301128-woe6knpv	136	24	as	as	IN
cord-301128-woe6knpv	136	25	topological	topological	JJ
cord-301128-woe6knpv	136	26	barriers	barrier	NNS
cord-301128-woe6knpv	136	27	.	.	.
cord-301128-woe6knpv	137	1	We	-PRON-	PRP
cord-301128-woe6knpv	137	2	showed	show	VBD
cord-301128-woe6knpv	137	3	that	that	IN
cord-301128-woe6knpv	137	4	these	these	DT
cord-301128-woe6knpv	137	5	proteins	protein	NNS
cord-301128-woe6knpv	137	6	This	this	DT
cord-301128-woe6knpv	137	7	work	work	NN
cord-301128-woe6knpv	137	8	also	also	RB
cord-301128-woe6knpv	137	9	brings	bring	VBZ
cord-301128-woe6knpv	137	10	some	some	DT
cord-301128-woe6knpv	137	11	light	light	NN
cord-301128-woe6knpv	137	12	on	on	IN
cord-301128-woe6knpv	137	13	another	another	DT
cord-301128-woe6knpv	137	14	mechanism	mechanism	NN
cord-301128-woe6knpv	137	15	that	that	WDT
cord-301128-woe6knpv	137	16	has	have	VBZ
cord-301128-woe6knpv	137	17	been	be	VBN
cord-301128-woe6knpv	137	18	proposed	propose	VBN
cord-301128-woe6knpv	137	19	to	to	TO
cord-301128-woe6knpv	137	20	explain	explain	VB
cord-301128-woe6knpv	137	21	the	the	DT
cord-301128-woe6knpv	137	22	formation	formation	NN
cord-301128-woe6knpv	137	23	of	of	IN
cord-301128-woe6knpv	137	24	independent	independent	JJ
cord-301128-woe6knpv	137	25	topological	topological	JJ
cord-301128-woe6knpv	137	26	domains	domain	NNS
cord-301128-woe6knpv	137	27	,	,	,
cord-301128-woe6knpv	137	28	namely	namely	RB
cord-301128-woe6knpv	137	29	two	two	CD
cord-301128-woe6knpv	137	30	proteins	protein	NNS
cord-301128-woe6knpv	137	31	wrapping	wrap	VBG
cord-301128-woe6knpv	137	32	the	the	DT
cord-301128-woe6knpv	137	33	DNA	dna	NN
cord-301128-woe6knpv	137	34	in	in	IN
cord-301128-woe6knpv	137	35	two	two	CD
cord-301128-woe6knpv	137	36	different	different	JJ
cord-301128-woe6knpv	137	37	locations	location	NNS
cord-301128-woe6knpv	137	38	(	(	-LRB-
cord-301128-woe6knpv	137	39	Ref	ref	NN
cord-301128-woe6knpv	137	40	.	.	.
cord-301128-woe6knpv	138	1	(	(	-LRB-
cord-301128-woe6knpv	138	2	15	15	CD
cord-301128-woe6knpv	138	3	)	)	-RRB-
cord-301128-woe6knpv	138	4	,	,	,
cord-301128-woe6knpv	138	5	Fig	Fig	NNP
cord-301128-woe6knpv	138	6	.	.	NNP
cord-301128-woe6knpv	138	7	6	6	CD
cord-301128-woe6knpv	138	8	)	)	-RRB-
cord-301128-woe6knpv	138	9	.	.	.
cord-301128-woe6knpv	139	1	There	there	EX
cord-301128-woe6knpv	139	2	is	be	VBZ
cord-301128-woe6knpv	139	3	experimental	experimental	JJ
cord-301128-woe6knpv	139	4	evidence	evidence	NN
cord-301128-woe6knpv	139	5	that	that	IN
cord-301128-woe6knpv	139	6	certain	certain	JJ
cord-301128-woe6knpv	139	7	wrapping	wrapping	NN
cord-301128-woe6knpv	139	8	proteins	protein	NNS
cord-301128-woe6knpv	139	9	,	,	,
cord-301128-woe6knpv	139	10	like	like	IN
cord-301128-woe6knpv	139	11	GalR	GalR	NNP
cord-301128-woe6knpv	139	12	(	(	-LRB-
cord-301128-woe6knpv	139	13	15	15	CD
cord-301128-woe6knpv	139	14	)	)	-RRB-
cord-301128-woe6knpv	139	15	,	,	,
cord-301128-woe6knpv	139	16	the	the	DT
cord-301128-woe6knpv	139	17	λ	λ	NN
cord-301128-woe6knpv	139	18	O	o	NN
cord-301128-woe6knpv	139	19	protein	protein	NN
cord-301128-woe6knpv	139	20	(	(	-LRB-
cord-301128-woe6knpv	139	21	15	15	CD
cord-301128-woe6knpv	139	22	)	)	-RRB-
cord-301128-woe6knpv	139	23	,	,	,
cord-301128-woe6knpv	139	24	and	and	CC
cord-301128-woe6knpv	139	25	Fis	Fis	NNP
cord-301128-woe6knpv	139	26	(	(	-LRB-
cord-301128-woe6knpv	139	27	62	62	CD
cord-301128-woe6knpv	139	28	)	)	-RRB-
cord-301128-woe6knpv	140	1	Another	another	DT
cord-301128-woe6knpv	140	2	model	model	NN
cord-301128-woe6knpv	140	3	which	which	WDT
cord-301128-woe6knpv	140	4	is	be	VBZ
cord-301128-woe6knpv	140	5	frequently	frequently	RB
cord-301128-woe6knpv	140	6	proposed	propose	VBN
cord-301128-woe6knpv	140	7	for	for	IN
cord-301128-woe6knpv	140	8	the	the	DT
cord-301128-woe6knpv	140	9	formation	formation	NN
cord-301128-woe6knpv	140	10	of	of	IN
cord-301128-woe6knpv	140	11	topological	topological	JJ
cord-301128-woe6knpv	140	12	barriers	barrier	NNS
cord-301128-woe6knpv	140	13	,	,	,
cord-301128-woe6knpv	140	14	namely	namely	RB
cord-301128-woe6knpv	140	15	actively	actively	RB
cord-301128-woe6knpv	140	16	transcribing	transcribe	VBG
cord-301128-woe6knpv	140	17	RNAP	RNAP	NNP
cord-301128-woe6knpv	140	18	(	(	-LRB-
cord-301128-woe6knpv	140	19	10	10	CD
cord-301128-woe6knpv	140	20	)	)	-RRB-
cord-301128-woe6knpv	140	21	(	(	-LRB-
cord-301128-woe6knpv	140	22	11	11	CD
cord-301128-woe6knpv	140	23	)	)	-RRB-
cord-301128-woe6knpv	140	24	(	(	-LRB-
cord-301128-woe6knpv	140	25	12	12	CD
cord-301128-woe6knpv	140	26	)	)	-RRB-
cord-301128-woe6knpv	140	27	,	,	,
cord-301128-woe6knpv	140	28	is	be	VBZ
cord-301128-woe6knpv	140	29	more	more	RBR
cord-301128-woe6knpv	140	30	difficult	difficult	JJ
cord-301128-woe6knpv	140	31	to	to	TO
cord-301128-woe6knpv	140	32	discuss	discuss	VB
cord-301128-woe6knpv	140	33	in	in	IN
cord-301128-woe6knpv	140	34	terms	term	NNS
cord-301128-woe6knpv	140	35	of	of	IN
cord-301128-woe6knpv	140	36	the	the	DT
cord-301128-woe6knpv	140	37	results	result	NNS
cord-301128-woe6knpv	140	38	described	describe	VBN
cord-301128-woe6knpv	140	39	in	in	IN
cord-301128-woe6knpv	140	40	this	this	DT
cord-301128-woe6knpv	140	41	paper	paper	NN
cord-301128-woe6knpv	140	42	,	,	,
cord-301128-woe6knpv	140	43	because	because	IN
cord-301128-woe6knpv	140	44	several	several	JJ
cord-301128-woe6knpv	140	45	time	time	NN
cord-301128-woe6knpv	140	46	scales	scale	NNS
cord-301128-woe6knpv	140	47	need	need	VBP
cord-301128-woe6knpv	140	48	be	be	VB
cord-301128-woe6knpv	140	49	considered	consider	VBN
cord-301128-woe6knpv	140	50	.	.	.
cord-301128-woe6knpv	141	1	Indeed	indeed	RB
cord-301128-woe6knpv	141	2	,	,	,
cord-301128-woe6knpv	141	3	it	-PRON-	PRP
cord-301128-woe6knpv	141	4	is	be	VBZ
cord-301128-woe6knpv	141	5	likely	likely	JJ
cord-301128-woe6knpv	141	6	that	that	IN
cord-301128-woe6knpv	141	7	the	the	DT
cord-301128-woe6knpv	141	8	two	two	CD
cord-301128-woe6knpv	141	9	parts	part	NNS
cord-301128-woe6knpv	141	10	of	of	IN
cord-301128-woe6knpv	141	11	the	the	DT
cord-301128-woe6knpv	141	12	DNA	dna	NN
cord-301128-woe6knpv	141	13	molecule	molecule	NN
cord-301128-woe6knpv	141	14	located	locate	VBN
cord-301128-woe6knpv	141	15	respectively	respectively	RB
cord-301128-woe6knpv	141	16	upstream	upstream	RB
cord-301128-woe6knpv	141	17	and	and	CC
cord-301128-woe6knpv	141	18	downstream	downstream	RB
cord-301128-woe6knpv	141	19	from	from	IN
cord-301128-woe6knpv	141	20	the	the	DT
cord-301128-woe6knpv	141	21	transcribing	transcribe	VBG
cord-301128-woe6knpv	141	22	RNAP	RNAP	NNP
cord-301128-woe6knpv	141	23	will	will	MD
cord-301128-woe6knpv	141	24	tend	tend	VB
cord-301128-woe6knpv	141	25	to	to	TO
cord-301128-woe6knpv	141	26	increase	increase	VB
cord-301128-woe6knpv	141	27	their	-PRON-	PRP$
cord-301128-woe6knpv	141	28	intricacy	intricacy	NN
cord-301128-woe6knpv	141	29	,	,	,
cord-301128-woe6knpv	141	30	in	in	IN
cord-301128-woe6knpv	141	31	order	order	NN
cord-301128-woe6knpv	141	32	to	to	TO
cord-301128-woe6knpv	141	33	reduce	reduce	VB
cord-301128-woe6knpv	141	34	the	the	DT
cord-301128-woe6knpv	141	35	torsional	torsional	JJ
cord-301128-woe6knpv	141	36	stress	stress	NN
cord-301128-woe6knpv	141	37	induced	induce	VBN
cord-301128-woe6knpv	141	38	by	by	IN
cord-301128-woe6knpv	141	39	the	the	DT
cord-301128-woe6knpv	141	40	blocking	blocking	NN
cord-301128-woe6knpv	141	41	of	of	IN
cord-301128-woe6knpv	141	42	the	the	DT
cord-301128-woe6knpv	141	43	diffusion	diffusion	NN
cord-301128-woe6knpv	141	44	of	of	IN
cord-301128-woe6knpv	141	45	twist	twist	NN
cord-301128-woe6knpv	141	46	at	at	IN
cord-301128-woe6knpv	141	47	the	the	DT
cord-301128-woe6knpv	141	48	RNAP	RNAP	NNP
cord-301128-woe6knpv	141	49	.	.	.
cord-301128-woe6knpv	142	1	However	however	RB
cord-301128-woe6knpv	142	2	,	,	,
cord-301128-woe6knpv	142	3	the	the	DT
cord-301128-woe6knpv	142	4	RNAP	RNAP	NNP
cord-301128-woe6knpv	142	5	is	be	VBZ
cord-301128-woe6knpv	142	6	itself	-PRON-	PRP
cord-301128-woe6knpv	142	7	moving	move	VBG
cord-301128-woe6knpv	142	8	forward	forward	RB
cord-301128-woe6knpv	142	9	along	along	IN
cord-301128-woe6knpv	142	10	the	the	DT
cord-301128-woe6knpv	142	11	DNA	dna	NN
cord-301128-woe6knpv	142	12	,	,	,
cord-301128-woe6knpv	142	13	so	so	IN
cord-301128-woe6knpv	142	14	that	that	IN
cord-301128-woe6knpv	142	15	the	the	DT
cord-301128-woe6knpv	142	16	ability	ability	NN
cord-301128-woe6knpv	142	17	of	of	IN
cord-301128-woe6knpv	142	18	transcribing	transcribe	VBG
cord-301128-woe6knpv	142	19	RNAP	RNAP	NNP
cord-301128-woe6knpv	142	20	to	to	TO
cord-301128-woe6knpv	142	21	act	act	VB
cord-301128-woe6knpv	142	22	as	as	IN
cord-301128-woe6knpv	142	23	topological	topological	JJ
cord-301128-woe6knpv	142	24	barriers	barrier	NNS
cord-301128-woe6knpv	142	25	probably	probably	RB
cord-301128-woe6knpv	142	26	depends	depend	VBZ
cord-301128-woe6knpv	142	27	on	on	IN
cord-301128-woe6knpv	142	28	the	the	DT
cord-301128-woe6knpv	142	29	relative	relative	JJ
cord-301128-woe6knpv	142	30	speeds	speed	NNS
cord-301128-woe6knpv	142	31	of	of	IN
cord-301128-woe6knpv	142	32	the	the	DT
cord-301128-woe6knpv	142	33	two	two	CD
cord-301128-woe6knpv	142	34	mechanisms	mechanism	NNS
cord-301128-woe6knpv	142	35	.	.	.
cord-301128-woe6knpv	143	1	More	More	JJR
cord-301128-woe6knpv	143	2	work	work	NN
cord-301128-woe6knpv	143	3	is	be	VBZ
cord-301128-woe6knpv	143	4	needed	need	VBN
cord-301128-woe6knpv	143	5	to	to	TO
cord-301128-woe6knpv	143	6	clarify	clarify	VB
cord-301128-woe6knpv	143	7	this	this	DT
cord-301128-woe6knpv	143	8	point	point	NN
cord-301128-woe6knpv	143	9	.	.	.
cord-301128-woe6knpv	144	1	Similarly	similarly	RB
cord-301128-woe6knpv	144	2	,	,	,
cord-301128-woe6knpv	144	3	the	the	DT
cord-301128-woe6knpv	144	4	case	case	NN
cord-301128-woe6knpv	144	5	of	of	IN
cord-301128-woe6knpv	144	6	DNA	dna	NN
cord-301128-woe6knpv	144	7	-	-	HYPH
cord-301128-woe6knpv	144	8	bending	bend	VBG
cord-301128-woe6knpv	144	9	nucleoid	nucleoid	NN
cord-301128-woe6knpv	144	10	proteins	protein	NNS
cord-301128-woe6knpv	144	11	,	,	,
cord-301128-woe6knpv	144	12	like	like	IN
cord-301128-woe6knpv	144	13	HU	HU	NNP
cord-301128-woe6knpv	144	14	(	(	-LRB-
cord-301128-woe6knpv	144	15	63	63	CD
cord-301128-woe6knpv	144	16	)	)	-RRB-
cord-301128-woe6knpv	144	17	,	,	,
cord-301128-woe6knpv	144	18	certainly	certainly	RB
cord-301128-woe6knpv	144	19	deserves	deserve	VBZ
cord-301128-woe6knpv	144	20	further	further	JJ
cord-301128-woe6knpv	144	21	investigations	investigation	NNS
cord-301128-woe6knpv	144	22	.	.	.
cord-301128-woe6knpv	145	1	Finally	finally	RB
cord-301128-woe6knpv	145	2	,	,	,
cord-301128-woe6knpv	145	3	we	-PRON-	PRP
cord-301128-woe6knpv	145	4	note	note	VBP
cord-301128-woe6knpv	145	5	with	with	IN
cord-301128-woe6knpv	145	6	interest	interest	NN
cord-301128-woe6knpv	145	7	that	that	IN
cord-301128-woe6knpv	145	8	the	the	DT
cord-301128-woe6knpv	145	9	intricate	intricate	JJ
cord-301128-woe6knpv	145	10	structure	structure	NN
cord-301128-woe6knpv	145	11	obtained	obtain	VBN
cord-301128-woe6knpv	145	12	with	with	IN
cord-301128-woe6knpv	145	13	DNA	dna	NN
cord-301128-woe6knpv	145	14	-	-	HYPH
cord-301128-woe6knpv	145	15	bridging	bridge	VBG
cord-301128-woe6knpv	145	16	proteins	protein	NNS
cord-301128-woe6knpv	145	17	that	that	WDT
cord-301128-woe6knpv	145	18	block	block	VBP
cord-301128-woe6knpv	145	19	the	the	DT
cord-301128-woe6knpv	145	20	diffusion	diffusion	NN
cord-301128-woe6knpv	145	21	of	of	IN
cord-301128-woe6knpv	145	22	twist	twist	NN
cord-301128-woe6knpv	145	23	along	along	IN
cord-301128-woe6knpv	145	24	the	the	DT
cord-301128-woe6knpv	145	25	DNA	dna	NN
cord-301128-woe6knpv	145	26	but	but	CC
cord-301128-woe6knpv	145	27	do	do	VBP
cord-301128-woe6knpv	145	28	not	not	RB
cord-301128-woe6knpv	145	29	prevent	prevent	VB
cord-301128-woe6knpv	145	30	the	the	DT
cord-301128-woe6knpv	145	31	relative	relative	JJ
cord-301128-woe6knpv	145	32	rotation	rotation	NN
cord-301128-woe6knpv	145	33	of	of	IN
cord-301128-woe6knpv	145	34	the	the	DT
cord-301128-woe6knpv	145	35	DNA	dna	NN
cord-301128-woe6knpv	145	36	segments	segment	NNS
cord-301128-woe6knpv	145	37	are	be	VBP
cord-301128-woe6knpv	145	38	highly	highly	RB
cord-301128-woe6knpv	145	39	compact	compact	JJ
cord-301128-woe6knpv	145	40	.	.	.
cord-301128-woe6knpv	146	1	It	-PRON-	PRP
cord-301128-woe6knpv	146	2	turns	turn	VBZ
cord-301128-woe6knpv	146	3	out	out	RP
cord-301128-woe6knpv	146	4	that	that	IN
cord-301128-woe6knpv	146	5	the	the	DT
cord-301128-woe6knpv	146	6	mechanism	mechanism	NN
cord-301128-woe6knpv	146	7	leading	lead	VBG
cord-301128-woe6knpv	146	8	to	to	IN
cord-301128-woe6knpv	146	9	the	the	DT
cord-301128-woe6knpv	146	10	formation	formation	NN
cord-301128-woe6knpv	146	11	of	of	IN
cord-301128-woe6knpv	146	12	the	the	DT
cord-301128-woe6knpv	146	13	bacterial	bacterial	JJ
cord-301128-woe6knpv	146	14	nucleoid	nucleoid	NN
cord-301128-woe6knpv	146	15	is	be	VBZ
cord-301128-woe6knpv	146	16	a	a	DT
cord-301128-woe6knpv	146	17	longstanding	longstanding	JJ
cord-301128-woe6knpv	146	18	but	but	CC
cord-301128-woe6knpv	146	19	still	still	RB
cord-301128-woe6knpv	146	20	lively	lively	RB
cord-301128-woe6knpv	146	21	debated	debate	VBN
cord-301128-woe6knpv	146	22	question	question	NN
cord-301128-woe6knpv	146	23	(	(	-LRB-
cord-301128-woe6knpv	146	24	31	31	CD
cord-301128-woe6knpv	146	25	,	,	,
cord-301128-woe6knpv	146	26	32	32	CD
cord-301128-woe6knpv	146	27	,	,	,
cord-301128-woe6knpv	146	28	(	(	-LRB-
cord-301128-woe6knpv	146	29	64	64	CD
cord-301128-woe6knpv	146	30	)	)	-RRB-
cord-301128-woe6knpv	147	1	(	(	-LRB-
cord-301128-woe6knpv	147	2	65	65	CD
cord-301128-woe6knpv	147	3	)	)	-RRB-
cord-301128-woe6knpv	148	1	(	(	-LRB-
cord-301128-woe6knpv	148	2	66	66	CD
cord-301128-woe6knpv	148	3	)	)	-RRB-
cord-301128-woe6knpv	149	1	(	(	-LRB-
cord-301128-woe6knpv	149	2	67	67	CD
cord-301128-woe6knpv	149	3	)	)	-RRB-
cord-301128-woe6knpv	149	4	.	.	.
cord-301128-woe6knpv	150	1	The	the	DT
cord-301128-woe6knpv	150	2	point	point	NN
cord-301128-woe6knpv	150	3	that	that	WDT
cord-301128-woe6knpv	150	4	has	have	VBZ
cord-301128-woe6knpv	150	5	puzzled	puzzle	VBN
cord-301128-woe6knpv	150	6	scientists	scientist	NNS
cord-301128-woe6knpv	150	7	for	for	IN
cord-301128-woe6knpv	150	8	decades	decade	NNS
cord-301128-woe6knpv	150	9	is	be	VBZ
cord-301128-woe6knpv	150	10	that	that	IN
cord-301128-woe6knpv	150	11	the	the	DT
cord-301128-woe6knpv	150	12	volume	volume	NN
cord-301128-woe6knpv	150	13	of	of	IN
cord-301128-woe6knpv	150	14	the	the	DT
cord-301128-woe6knpv	150	15	Fig	Fig	NNP
cord-301128-woe6knpv	150	16	.	.	.
cord-301128-woe6knpv	150	17	1(b	1(b	CD
cord-301128-woe6knpv	150	18	)	)	-RRB-
cord-301128-woe6knpv	150	19	under	under	IN
cord-301128-woe6knpv	150	20	the	the	DT
cord-301128-woe6knpv	150	21	constraint	constraint	NN
cord-301128-woe6knpv	150	22	that	that	WDT
cord-301128-woe6knpv	150	23	beads	bead	NNS
cord-301128-woe6knpv	150	24	α	α	NN
cord-301128-woe6knpv	150	25	and	and	CC
cord-301128-woe6knpv	150	26	β	β	NN
cord-301128-woe6knpv	150	27	are	be	VBP
cord-301128-woe6knpv	150	28	bonded	bond	VBN
cord-301128-woe6knpv	150	29	(	(	-LRB-
cord-301128-woe6knpv	150	30	Eq	Eq	NNP
cord-301128-woe6knpv	150	31	.	.	.
cord-301128-woe6knpv	151	1	(	(	-LRB-
cord-301128-woe6knpv	151	2	3	3	LS
cord-301128-woe6knpv	151	3	)	)	-RRB-
cord-301128-woe6knpv	151	4	)	)	-RRB-
cord-301128-woe6knpv	151	5	.	.	.
cord-301128-woe6knpv	152	1	(	(	-LRB-
cord-301128-woe6knpv	152	2	b	b	LS
cord-301128-woe6knpv	152	3	)	)	-RRB-
cord-301128-woe6knpv	152	4	Representative	representative	JJ
cord-301128-woe6knpv	152	5	snapshot	snapshot	NN
cord-301128-woe6knpv	152	6	obtained	obtain	VBN
cord-301128-woe6knpv	152	7	upon	upon	IN
cord-301128-woe6knpv	152	8	relaxation	relaxation	NN
cord-301128-woe6knpv	152	9	of	of	IN
cord-301128-woe6knpv	152	10	the	the	DT
cord-301128-woe6knpv	152	11	out	out	RB
cord-301128-woe6knpv	152	12	-	-	HYPH
cord-301128-woe6knpv	152	13	of	of	IN
cord-301128-woe6knpv	152	14	equilibrium	equilibrium	NN
cord-301128-woe6knpv	152	15	conformation	conformation	NN
cord-301128-woe6knpv	152	16	shown	show	VBN
cord-301128-woe6knpv	152	17	in	in	IN
cord-301128-woe6knpv	152	18	Fig	Fig	NNP
cord-301128-woe6knpv	152	19	.	.	.
cord-301128-woe6knpv	152	20	1(b	1(b	CD
cord-301128-woe6knpv	152	21	)	)	-RRB-
cord-301128-woe6knpv	152	22	for	for	IN
cord-301128-woe6knpv	152	23	the	the	DT
cord-301128-woe6knpv	152	24	second	second	JJ
cord-301128-woe6knpv	152	25	model	model	NN
cord-301128-woe6knpv	152	26	of	of	IN
cord-301128-woe6knpv	152	27	DNA	dna	NN
cord-301128-woe6knpv	152	28	-	-	HYPH
cord-301128-woe6knpv	152	29	bridging	bridge	VBG
cord-301128-woe6knpv	152	30	proteins	protein	NNS
cord-301128-woe6knpv	152	31	(	(	-LRB-
cord-301128-woe6knpv	152	32	Eqs	Eqs	NNP
cord-301128-woe6knpv	152	33	.	.	.
cord-301128-woe6knpv	153	1	(	(	-LRB-
cord-301128-woe6knpv	153	2	5	5	LS
cord-301128-woe6knpv	153	3	)	)	-RRB-
cord-301128-woe6knpv	153	4	and	and	CC
cord-301128-woe6knpv	153	5	(	(	-LRB-
cord-301128-woe6knpv	153	6	6	6	CD
cord-301128-woe6knpv	153	7	)	)	-RRB-
cord-301128-woe6knpv	153	8	)	)	-RRB-
cord-301128-woe6knpv	153	9	.	.	.
cord-301128-woe6knpv	154	1	(	(	-LRB-
cord-301128-woe6knpv	154	2	c	c	NN
cord-301128-woe6knpv	154	3	)	)	-RRB-
cord-301128-woe6knpv	154	4	Representative	representative	JJ
cord-301128-woe6knpv	154	5	snapshot	snapshot	NN
cord-301128-woe6knpv	154	6	obtained	obtain	VBN
cord-301128-woe6knpv	154	7	upon	upon	IN
cord-301128-woe6knpv	154	8	relaxation	relaxation	NN
cord-301128-woe6knpv	154	9	of	of	IN
cord-301128-woe6knpv	154	10	the	the	DT
cord-301128-woe6knpv	154	11	out	out	RB
cord-301128-woe6knpv	154	12	-	-	HYPH
cord-301128-woe6knpv	154	13	of	of	IN
cord-301128-woe6knpv	154	14	equilibrium	equilibrium	NN
cord-301128-woe6knpv	154	15	conformation	conformation	NN
cord-301128-woe6knpv	154	16	shown	show	VBN
cord-301128-woe6knpv	154	17	in	in	IN
cord-301128-woe6knpv	154	18	Fig	Fig	NNP
cord-301128-woe6knpv	154	19	.	.	.
cord-301128-woe6knpv	154	20	1(b	1(b	CD
cord-301128-woe6knpv	154	21	)	)	-RRB-
cord-301128-woe6knpv	154	22	for	for	IN
cord-301128-woe6knpv	154	23	the	the	DT
cord-301128-woe6knpv	154	24	third	third	JJ
cord-301128-woe6knpv	154	25	model	model	NN
cord-301128-woe6knpv	154	26	of	of	IN
cord-301128-woe6knpv	154	27	DNA	dna	NN
cord-301128-woe6knpv	154	28	-	-	HYPH
cord-301128-woe6knpv	154	29	bridging	bridge	VBG
cord-301128-woe6knpv	154	30	proteins	protein	NNS
cord-301128-woe6knpv	154	31	(	(	-LRB-
cord-301128-woe6knpv	154	32	Eqs	Eqs	NNP
cord-301128-woe6knpv	154	33	.	.	.
cord-301128-woe6knpv	155	1	(	(	-LRB-
cord-301128-woe6knpv	155	2	5	5	LS
cord-301128-woe6knpv	155	3	)	)	-RRB-
cord-301128-woe6knpv	155	4	and	and	CC
cord-301128-woe6knpv	155	5	(	(	-LRB-
cord-301128-woe6knpv	155	6	7	7	CD
cord-301128-woe6knpv	155	7	)	)	-RRB-
cord-301128-woe6knpv	155	8	)	)	-RRB-
cord-301128-woe6knpv	155	9	.	.	.
cord-301128-woe6knpv	156	1	The	the	DT
cord-301128-woe6knpv	156	2	 	 	_SP
cord-301128-woe6knpv	156	3	imagined	imagine	VBD
cord-301128-woe6knpv	156	4	the	the	DT
cord-301128-woe6knpv	156	5	research	research	NN
cord-301128-woe6knpv	156	6	project	project	NN
cord-301128-woe6knpv	156	7	and	and	CC
cord-301128-woe6knpv	156	8	performed	perform	VBD
cord-301128-woe6knpv	156	9	preliminary	preliminary	JJ
cord-301128-woe6knpv	156	10	simulations	simulation	NNS
cord-301128-woe6knpv	156	11	.	.	.
cord-301128-woe6knpv	157	1	M.J.	M.J.	NNP
cord-301128-woe6knpv	157	2	developed	develop	VBD
cord-301128-woe6knpv	157	3	the	the	DT
cord-301128-woe6knpv	157	4	models	model	NNS
cord-301128-woe6knpv	157	5	,	,	,
cord-301128-woe6knpv	157	6	ran	run	VBD
cord-301128-woe6knpv	157	7	the	the	DT
cord-301128-woe6knpv	157	8	simulations	simulation	NNS
cord-301128-woe6knpv	157	9	and	and	CC
cord-301128-woe6knpv	157	10	analyzed	analyze	VBD
cord-301128-woe6knpv	157	11	the	the	DT
cord-301128-woe6knpv	157	12	results	result	NNS
cord-301128-woe6knpv	157	13	.	.	.
cord-301128-woe6knpv	158	1	M.J.	M.J.	NNP
cord-301128-woe6knpv	158	2	and	and	CC
cord-301128-woe6knpv	158	3	I.J.	I.J.	NNP
cord-301128-woe6knpv	158	4	wrote	write	VBD
cord-301128-woe6knpv	158	5	the	the	DT
cord-301128-woe6knpv	158	6	manuscript	manuscript	NN
cord-301128-woe6knpv	158	7	Université	Université	NNP
cord-301128-woe6knpv	158	8	Lumière	Lumière	NNP
cord-301128-woe6knpv	158	9	Lyon	Lyon	NNP
cord-301128-woe6knpv	158	10	2	2	CD
cord-301128-woe6knpv	158	11	)	)	-RRB-
cord-301128-woe6knpv	158	12	for	for	IN
cord-301128-woe6knpv	158	13	her	-PRON-	PRP$
cord-301128-woe6knpv	158	14	hospitality	hospitality	NN
cord-301128-woe6knpv	158	15	during	during	IN
cord-301128-woe6knpv	158	16	the	the	DT
cord-301128-woe6knpv	158	17	Covid-19	covid-19	JJ
cord-301128-woe6knpv	158	18	epidemic	epidemic	NN
cord-301128-woe6knpv	158	19	confinement	confinement	NN
cord-301128-woe6knpv	158	20	DNA	dna	NN
cord-301128-woe6knpv	158	21	topology	topology	NN
cord-301128-woe6knpv	159	1	On	on	IN
cord-301128-woe6knpv	159	2	the	the	DT
cord-301128-woe6knpv	159	3	structure	structure	NN
cord-301128-woe6knpv	159	4	of	of	IN
cord-301128-woe6knpv	159	5	the	the	DT
cord-301128-woe6knpv	159	6	folded	fold	VBN
cord-301128-woe6knpv	159	7	chromosome	chromosome	NN
cord-301128-woe6knpv	159	8	of	of	IN
cord-301128-woe6knpv	159	9	Escherichia	escherichia	NN
cord-301128-woe6knpv	159	10	coli	coli	NNS
cord-301128-woe6knpv	159	11	Chromosomes	chromosome	NNS
cord-301128-woe6knpv	159	12	in	in	IN
cord-301128-woe6knpv	159	13	living	live	VBG
cord-301128-woe6knpv	159	14	Escherichia	Escherichia	NNP
cord-301128-woe6knpv	159	15	coli	coli	NNS
cord-301128-woe6knpv	159	16	cells	cell	NNS
cord-301128-woe6knpv	159	17	are	be	VBP
cord-301128-woe6knpv	159	18	segregated	segregate	VBN
cord-301128-woe6knpv	159	19	into	into	IN
cord-301128-woe6knpv	159	20	domains	domain	NNS
cord-301128-woe6knpv	159	21	of	of	IN
cord-301128-woe6knpv	159	22	supercoiling	supercoile	VBG
cord-301128-woe6knpv	159	23	Topological	topological	JJ
cord-301128-woe6knpv	159	24	domain	domain	NN
cord-301128-woe6knpv	159	25	structure	structure	NN
cord-301128-woe6knpv	159	26	of	of	IN
cord-301128-woe6knpv	159	27	the	the	DT
cord-301128-woe6knpv	159	28	Escherichia	Escherichia	NNP
cord-301128-woe6knpv	159	29	coli	coli	NNS
cord-301128-woe6knpv	159	30	chromosome	chromosome	NN
cord-301128-woe6knpv	159	31	Universal	universal	JJ
cord-301128-woe6knpv	159	32	and	and	CC
cord-301128-woe6knpv	159	33	idiosyncratic	idiosyncratic	JJ
cord-301128-woe6knpv	159	34	characteristic	characteristic	JJ
cord-301128-woe6knpv	159	35	lengths	length	NNS
cord-301128-woe6knpv	159	36	in	in	IN
cord-301128-woe6knpv	159	37	bacterial	bacterial	JJ
cord-301128-woe6knpv	159	38	genomes	genome	NNS
cord-301128-woe6knpv	159	39	Conserved	conserve	VBN
cord-301128-woe6knpv	159	40	units	unit	NNS
cord-301128-woe6knpv	159	41	of	of	IN
cord-301128-woe6knpv	159	42	co	co	NN
cord-301128-woe6knpv	159	43	-	-	NN
cord-301128-woe6knpv	159	44	expression	expression	NN
cord-301128-woe6knpv	159	45	in	in	IN
cord-301128-woe6knpv	159	46	bacterial	bacterial	JJ
cord-301128-woe6knpv	159	47	genomes	genome	NNS
cord-301128-woe6knpv	159	48	:	:	:
cord-301128-woe6knpv	159	49	An	an	DT
cord-301128-woe6knpv	159	50	evolutionary	evolutionary	JJ
cord-301128-woe6knpv	159	51	insight	insight	NN
cord-301128-woe6knpv	159	52	into	into	IN
cord-301128-woe6knpv	159	53	transcriptional	transcriptional	JJ
cord-301128-woe6knpv	159	54	regulation	regulation	NN
cord-301128-woe6knpv	160	1	The	the	DT
cord-301128-woe6knpv	160	2	structure	structure	NN
cord-301128-woe6knpv	160	3	and	and	CC
cord-301128-woe6knpv	160	4	function	function	NN
cord-301128-woe6knpv	160	5	of	of	IN
cord-301128-woe6knpv	160	6	the	the	DT
cord-301128-woe6knpv	160	7	bacterial	bacterial	JJ
cord-301128-woe6knpv	160	8	chromosome	chromosome	NN
cord-301128-woe6knpv	160	9	Topological	topological	JJ
cord-301128-woe6knpv	160	10	insulators	insulator	NNS
cord-301128-woe6knpv	160	11	inhibit	inhibit	VBP
cord-301128-woe6knpv	160	12	diffusion	diffusion	NN
cord-301128-woe6knpv	160	13	of	of	IN
cord-301128-woe6knpv	160	14	transcription	transcription	NN
cord-301128-woe6knpv	160	15	-	-	HYPH
cord-301128-woe6knpv	160	16	induced	induce	VBN
cord-301128-woe6knpv	160	17	positive	positive	JJ
cord-301128-woe6knpv	160	18	supercoils	supercoil	NNS
cord-301128-woe6knpv	160	19	in	in	IN
cord-301128-woe6knpv	160	20	the	the	DT
cord-301128-woe6knpv	160	21	chromosome	chromosome	NN
cord-301128-woe6knpv	160	22	of	of	IN
cord-301128-woe6knpv	160	23	Escherichia	Escherichia	NNP
cord-301128-woe6knpv	160	24	coli	coli	NNS
cord-301128-woe6knpv	160	25	Supercoiling	Supercoiling	NNP
cord-301128-woe6knpv	160	26	of	of	IN
cord-301128-woe6knpv	160	27	the	the	DT
cord-301128-woe6knpv	160	28	DNA	dna	NN
cord-301128-woe6knpv	160	29	template	template	NN
cord-301128-woe6knpv	160	30	during	during	IN
cord-301128-woe6knpv	160	31	transcription	transcription	NN
cord-301128-woe6knpv	160	32	Transcription	transcription	NN
cord-301128-woe6knpv	160	33	-	-	HYPH
cord-301128-woe6knpv	160	34	induced	induce	VBN
cord-301128-woe6knpv	160	35	barriers	barrier	NNS
cord-301128-woe6knpv	160	36	to	to	TO
cord-301128-woe6knpv	160	37	supercoil	supercoil	VB
cord-301128-woe6knpv	160	38	diffusion	diffusion	NN
cord-301128-woe6knpv	160	39	in	in	IN
cord-301128-woe6knpv	160	40	the	the	DT
cord-301128-woe6knpv	160	41	Salmonella	Salmonella	NNP
cord-301128-woe6knpv	160	42	typhimurium	typhimurium	NN
cord-301128-woe6knpv	160	43	chromosome	chromosome	NNP
cord-301128-woe6knpv	160	44	Organization	Organization	NNP
cord-301128-woe6knpv	160	45	of	of	IN
cord-301128-woe6knpv	160	46	supercoil	supercoil	NNP
cord-301128-woe6knpv	160	47	domains	domain	NNS
cord-301128-woe6knpv	160	48	and	and	CC
cord-301128-woe6knpv	160	49	their	-PRON-	PRP$
cord-301128-woe6knpv	160	50	reorganization	reorganization	NN
cord-301128-woe6knpv	160	51	by	by	IN
cord-301128-woe6knpv	160	52	transcription	transcription	NN
cord-301128-woe6knpv	160	53	Recombination	Recombination	NNP
cord-301128-woe6knpv	160	54	by	by	IN
cord-301128-woe6knpv	160	55	resolvase	resolvase	NNP
cord-301128-woe6knpv	160	56	is	be	VBZ
cord-301128-woe6knpv	160	57	inhibited	inhibit	VBN
cord-301128-woe6knpv	160	58	by	by	IN
cord-301128-woe6knpv	160	59	lac	lac	NNP
cord-301128-woe6knpv	160	60	repressor	repressor	NN
cord-301128-woe6knpv	160	61	simultaneously	simultaneously	RB
cord-301128-woe6knpv	160	62	binding	bind	VBG
cord-301128-woe6knpv	160	63	operators	operator	NNS
cord-301128-woe6knpv	160	64	between	between	IN
cord-301128-woe6knpv	160	65	res	re	NNS
cord-301128-woe6knpv	160	66	sites	site	NNS
cord-301128-woe6knpv	160	67	DNA	dna	NN
cord-301128-woe6knpv	160	68	looping	looping	NN
cord-301128-woe6knpv	160	69	alters	alter	VBZ
cord-301128-woe6knpv	160	70	local	local	JJ
cord-301128-woe6knpv	160	71	DNA	dna	NN
cord-301128-woe6knpv	160	72	conformation	conformation	NN
cord-301128-woe6knpv	160	73	during	during	IN
cord-301128-woe6knpv	160	74	transcription	transcription	NN
cord-301128-woe6knpv	160	75	Dividing	divide	VBG
cord-301128-woe6knpv	160	76	a	a	DT
cord-301128-woe6knpv	160	77	supercoiled	supercoile	VBN
cord-301128-woe6knpv	160	78	DNA	dna	NN
cord-301128-woe6knpv	160	79	molecule	molecule	NN
cord-301128-woe6knpv	160	80	into	into	IN
cord-301128-woe6knpv	160	81	two	two	CD
cord-301128-woe6knpv	160	82	independent	independent	JJ
cord-301128-woe6knpv	160	83	topological	topological	JJ
cord-301128-woe6knpv	160	84	domains	domain	NNS
cord-301128-woe6knpv	160	85	Protein	protein	NN
cord-301128-woe6knpv	160	86	-	-	HYPH
cord-301128-woe6knpv	160	87	mediated	mediate	VBN
cord-301128-woe6knpv	160	88	loops	loop	NNS
cord-301128-woe6knpv	160	89	in	in	IN
cord-301128-woe6knpv	160	90	supercoiled	supercoiled	JJ
cord-301128-woe6knpv	160	91	DNA	DNA	NNP
cord-301128-woe6knpv	160	92	create	create	VBP
cord-301128-woe6knpv	160	93	large	large	JJ
cord-301128-woe6knpv	160	94	topological	topological	JJ
cord-301128-woe6knpv	160	95	domains	domain	NNS
cord-301128-woe6knpv	161	1	Some	some	DT
cord-301128-woe6knpv	161	2	repressors	repressor	NNS
cord-301128-woe6knpv	161	3	of	of	IN
cord-301128-woe6knpv	161	4	bacterial	bacterial	JJ
cord-301128-woe6knpv	161	5	transcription	transcription	NN
cord-301128-woe6knpv	161	6	H	H	NNP
cord-301128-woe6knpv	161	7	-	-	HYPH
cord-301128-woe6knpv	161	8	NS	NS	NNP
cord-301128-woe6knpv	161	9	mediated	mediate	VBN
cord-301128-woe6knpv	161	10	compaction	compaction	NN
cord-301128-woe6knpv	161	11	of	of	IN
cord-301128-woe6knpv	161	12	DNA	dna	NN
cord-301128-woe6knpv	161	13	visualised	visualise	VBN
cord-301128-woe6knpv	161	14	by	by	IN
cord-301128-woe6knpv	161	15	atomic	atomic	JJ
cord-301128-woe6knpv	161	16	force	force	NN
cord-301128-woe6knpv	161	17	microscopy	microscopy	NNP
cord-301128-woe6knpv	162	1	The	the	DT
cord-301128-woe6knpv	162	2	structural	structural	JJ
cord-301128-woe6knpv	162	3	and	and	CC
cord-301128-woe6knpv	162	4	functional	functional	JJ
cord-301128-woe6knpv	162	5	organization	organization	NN
cord-301128-woe6knpv	162	6	of	of	IN
cord-301128-woe6knpv	162	7	H	H	NNP
cord-301128-woe6knpv	162	8	-	-	HYPH
cord-301128-woe6knpv	162	9	NS	NS	NNP
cord-301128-woe6knpv	162	10	-	-	HYPH
cord-301128-woe6knpv	162	11	like	like	JJ
cord-301128-woe6knpv	162	12	proteins	protein	NNS
cord-301128-woe6knpv	162	13	is	be	VBZ
cord-301128-woe6knpv	162	14	evolutionarily	evolutionarily	RB
cord-301128-woe6knpv	162	15	conserved	conserve	VBN
cord-301128-woe6knpv	162	16	in	in	IN
cord-301128-woe6knpv	162	17	Gram	gram	NN
cord-301128-woe6knpv	162	18	-	-	HYPH
cord-301128-woe6knpv	162	19	negative	negative	JJ
cord-301128-woe6knpv	162	20	bacteria	bacteria	NNS
cord-301128-woe6knpv	162	21	Lsr2	Lsr2	NNP
cord-301128-woe6knpv	162	22	of	of	IN
cord-301128-woe6knpv	162	23	Mycobacterium	Mycobacterium	NNP
cord-301128-woe6knpv	162	24	tuberculosis	tuberculosis	NN
cord-301128-woe6knpv	162	25	is	be	VBZ
cord-301128-woe6knpv	162	26	a	a	DT
cord-301128-woe6knpv	162	27	DNA	dna	NN
cord-301128-woe6knpv	162	28	-	-	HYPH
cord-301128-woe6knpv	162	29	bridging	bridge	VBG
cord-301128-woe6knpv	162	30	protein	protein	NN
cord-301128-woe6knpv	162	31	Mechanism	Mechanism	NNP
cord-301128-woe6knpv	162	32	of	of	IN
cord-301128-woe6knpv	162	33	chromosome	chromosome	NN
cord-301128-woe6knpv	162	34	compaction	compaction	NN
cord-301128-woe6knpv	162	35	and	and	CC
cord-301128-woe6knpv	162	36	looping	looping	NN
cord-301128-woe6knpv	162	37	by	by	IN
cord-301128-woe6knpv	162	38	the	the	DT
cord-301128-woe6knpv	162	39	Escherichia	Escherichia	NNP
cord-301128-woe6knpv	162	40	coli	coli	NNS
cord-301128-woe6knpv	163	1	nucleoid	nucleoid	NNP
cord-301128-woe6knpv	163	2	protein	protein	NN
cord-301128-woe6knpv	163	3	Fis	Fis	NNP
cord-301128-woe6knpv	164	1	The	the	DT
cord-301128-woe6knpv	164	2	role	role	NN
cord-301128-woe6knpv	164	3	of	of	IN
cord-301128-woe6knpv	164	4	high	high	JJ
cord-301128-woe6knpv	164	5	affinity	affinity	NN
cord-301128-woe6knpv	164	6	nonspecific	nonspecific	JJ
cord-301128-woe6knpv	164	7	DNA	dna	NN
cord-301128-woe6knpv	164	8	binding	binding	NN
cord-301128-woe6knpv	164	9	by	by	IN
cord-301128-woe6knpv	164	10	Lrp	Lrp	NNP
cord-301128-woe6knpv	164	11	in	in	IN
cord-301128-woe6knpv	164	12	transcriptional	transcriptional	JJ
cord-301128-woe6knpv	164	13	regulation	regulation	NN
cord-301128-woe6knpv	164	14	and	and	CC
cord-301128-woe6knpv	164	15	DNA	dna	NN
cord-301128-woe6knpv	164	16	organization	organization	NN
cord-301128-woe6knpv	164	17	DNA	dna	NN
cord-301128-woe6knpv	164	18	supercoiling	supercoiling	NN
cord-301128-woe6knpv	164	19	,	,	,
cord-301128-woe6knpv	164	20	a	a	DT
cord-301128-woe6knpv	164	21	critical	critical	JJ
cord-301128-woe6knpv	164	22	signal	signal	NN
cord-301128-woe6knpv	164	23	regulating	regulate	VBG
cord-301128-woe6knpv	164	24	the	the	DT
cord-301128-woe6knpv	164	25	basal	basal	JJ
cord-301128-woe6knpv	164	26	expression	expression	NN
cord-301128-woe6knpv	164	27	of	of	IN
cord-301128-woe6knpv	164	28	the	the	DT
cord-301128-woe6knpv	164	29	lac	lac	NNP
cord-301128-woe6knpv	164	30	operon	operon	NN
cord-301128-woe6knpv	164	31	in	in	IN
cord-301128-woe6knpv	164	32	Escherichia	Escherichia	NNP
cord-301128-woe6knpv	164	33	coli	coli	NNS
cord-301128-woe6knpv	164	34	bp	bp	NNP
cord-301128-woe6knpv	164	35	LacI	LacI	NNP
cord-301128-woe6knpv	164	36	-	-	HYPH
cord-301128-woe6knpv	164	37	mediated	mediate	VBN
cord-301128-woe6knpv	164	38	,	,	,
cord-301128-woe6knpv	164	39	negatively	negatively	RB
cord-301128-woe6knpv	164	40	supercoiled	supercoile	VBN
cord-301128-woe6knpv	164	41	DNA	dna	NN
cord-301128-woe6knpv	164	42	loop	loop	NN
cord-301128-woe6knpv	164	43	by	by	IN
cord-301128-woe6knpv	164	44	atomic	atomic	JJ
cord-301128-woe6knpv	164	45	force	force	NN
cord-301128-woe6knpv	164	46	microscope	microscope	NN
cord-301128-woe6knpv	164	47	Description	Description	NNP
cord-301128-woe6knpv	164	48	of	of	IN
cord-301128-woe6knpv	164	49	non	non	JJ
cord-301128-woe6knpv	164	50	-	-	JJ
cord-301128-woe6knpv	164	51	specific	specific	JJ
cord-301128-woe6knpv	164	52	DNA	dna	NN
cord-301128-woe6knpv	164	53	-	-	HYPH
cord-301128-woe6knpv	164	54	protein	protein	NN
cord-301128-woe6knpv	164	55	interaction	interaction	NN
cord-301128-woe6knpv	164	56	and	and	CC
cord-301128-woe6knpv	164	57	facilitated	facilitate	VBN
cord-301128-woe6knpv	164	58	diffusion	diffusion	NN
cord-301128-woe6knpv	164	59	with	with	IN
cord-301128-woe6knpv	164	60	a	a	DT
cord-301128-woe6knpv	164	61	dynamical	dynamical	JJ
cord-301128-woe6knpv	164	62	model	model	NN
cord-301128-woe6knpv	164	63	Dynamical	dynamical	JJ
cord-301128-woe6knpv	164	64	model	model	NN
cord-301128-woe6knpv	164	65	of	of	IN
cord-301128-woe6knpv	164	66	DNA	dna	NN
cord-301128-woe6knpv	164	67	protein	protein	NN
cord-301128-woe6knpv	164	68	interaction	interaction	NN
cord-301128-woe6knpv	164	69	:	:	:
cord-301128-woe6knpv	164	70	effect	effect	NN
cord-301128-woe6knpv	164	71	of	of	IN
cord-301128-woe6knpv	164	72	protein	protein	NN
cord-301128-woe6knpv	164	73	charge	charge	NN
cord-301128-woe6knpv	164	74	distribution	distribution	NN
cord-301128-woe6knpv	164	75	and	and	CC
cord-301128-woe6knpv	164	76	mechanical	mechanical	JJ
cord-301128-woe6knpv	164	77	properties	property	NNS
cord-301128-woe6knpv	165	1	Comparison	comparison	NN
cord-301128-woe6knpv	165	2	of	of	IN
cord-301128-woe6knpv	165	3	kinetic	kinetic	JJ
cord-301128-woe6knpv	165	4	and	and	CC
cord-301128-woe6knpv	165	5	dynamical	dynamical	JJ
cord-301128-woe6knpv	165	6	models	model	NNS
cord-301128-woe6knpv	165	7	of	of	IN
cord-301128-woe6knpv	165	8	DNA	dna	NN
cord-301128-woe6knpv	165	9	-	-	HYPH
cord-301128-woe6knpv	165	10	protein	protein	NN
cord-301128-woe6knpv	165	11	interaction	interaction	NN
cord-301128-woe6knpv	165	12	and	and	CC
cord-301128-woe6knpv	165	13	facilitated	facilitate	VBN
cord-301128-woe6knpv	165	14	diffusion	diffusion	NN
cord-301128-woe6knpv	165	15	A	a	DT
cord-301128-woe6knpv	165	16	model	model	NN
cord-301128-woe6knpv	165	17	of	of	IN
cord-301128-woe6knpv	165	18	H	H	NNP
cord-301128-woe6knpv	165	19	-	-	HYPH
cord-301128-woe6knpv	165	20	NS	NS	NNP
cord-301128-woe6knpv	165	21	mediated	mediate	VBN
cord-301128-woe6knpv	165	22	compaction	compaction	NN
cord-301128-woe6knpv	165	23	of	of	IN
cord-301128-woe6knpv	165	24	bacterial	bacterial	JJ
cord-301128-woe6knpv	165	25	DNA	DNA	NNP
cord-301128-woe6knpv	165	26	Equilibration	Equilibration	NNP
cord-301128-woe6knpv	165	27	of	of	IN
cord-301128-woe6knpv	165	28	complexes	complex	NNS
cord-301128-woe6knpv	165	29	of	of	IN
cord-301128-woe6knpv	165	30	DNA	DNA	NNP
cord-301128-woe6knpv	165	31	and	and	CC
cord-301128-woe6knpv	165	32	H	H	NNP
cord-301128-woe6knpv	165	33	-	-	HYPH
cord-301128-woe6knpv	165	34	NS	NS	NNP
cord-301128-woe6knpv	165	35	proteins	protein	NNS
cord-301128-woe6knpv	165	36	on	on	IN
cord-301128-woe6knpv	165	37	charged	charge	VBN
cord-301128-woe6knpv	165	38	surfaces	surface	NNS
cord-301128-woe6knpv	165	39	:	:	:
cord-301128-woe6knpv	165	40	A	a	DT
cord-301128-woe6knpv	165	41	coarse	coarse	RB
cord-301128-woe6knpv	165	42	-	-	HYPH
cord-301128-woe6knpv	165	43	grained	grained	JJ
cord-301128-woe6knpv	165	44	model	model	NN
cord-301128-woe6knpv	165	45	point	point	NN
cord-301128-woe6knpv	165	46	of	of	IN
cord-301128-woe6knpv	165	47	view	view	NN
cord-301128-woe6knpv	165	48	Role	role	NN
cord-301128-woe6knpv	165	49	of	of	IN
cord-301128-woe6knpv	165	50	salt	salt	NN
cord-301128-woe6knpv	165	51	valency	valency	NN
cord-301128-woe6knpv	165	52	in	in	IN
cord-301128-woe6knpv	165	53	the	the	DT
cord-301128-woe6knpv	165	54	switch	switch	NN
cord-301128-woe6knpv	165	55	of	of	IN
cord-301128-woe6knpv	165	56	H	H	NNP
cord-301128-woe6knpv	165	57	-	-	HYPH
cord-301128-woe6knpv	165	58	NS	NS	NNP
cord-301128-woe6knpv	165	59	proteins	protein	NNS
cord-301128-woe6knpv	165	60	between	between	IN
cord-301128-woe6knpv	165	61	DNAbridging	dnabridging	NN
cord-301128-woe6knpv	165	62	and	and	CC
cord-301128-woe6knpv	165	63	DNA	dna	NN
cord-301128-woe6knpv	165	64	-	-	HYPH
cord-301128-woe6knpv	165	65	stiffening	stiffen	VBG
cord-301128-woe6knpv	165	66	modes	mode	NNS
cord-301128-woe6knpv	165	67	Compaction	Compaction	NNP
cord-301128-woe6knpv	165	68	of	of	IN
cord-301128-woe6knpv	165	69	bacterial	bacterial	JJ
cord-301128-woe6knpv	165	70	genomic	genomic	JJ
cord-301128-woe6knpv	165	71	DNA	dna	NN
cord-301128-woe6knpv	165	72	:	:	:
cord-301128-woe6knpv	166	1	Clarifying	clarify	VBG
cord-301128-woe6knpv	166	2	the	the	DT
cord-301128-woe6knpv	166	3	concepts	concept	NNS
cord-301128-woe6knpv	166	4	In	in	IN
cord-301128-woe6knpv	166	5	vivo	vivo	NN
cord-301128-woe6knpv	166	6	compaction	compaction	NN
cord-301128-woe6knpv	166	7	dynamics	dynamic	NNS
cord-301128-woe6knpv	166	8	of	of	IN
cord-301128-woe6knpv	166	9	bacterial	bacterial	JJ
cord-301128-woe6knpv	166	10	DNA	dna	NN
cord-301128-woe6knpv	166	11	:	:	:
cord-301128-woe6knpv	167	1	A	a	DT
cord-301128-woe6knpv	167	2	fingerprint	fingerprint	NN
cord-301128-woe6knpv	167	3	of	of	IN
cord-301128-woe6knpv	167	4	DNA	DNA	NNP
cord-301128-woe6knpv	167	5	/	/	SYM
cord-301128-woe6knpv	167	6	RNA	RNA	NNP
cord-301128-woe6knpv	167	7	demixing	demixe	VBG
cord-301128-woe6knpv	167	8	?	?	.
cord-301128-woe6knpv	168	1	Coarse	coarse	JJ
cord-301128-woe6knpv	168	2	-	-	HYPH
cord-301128-woe6knpv	168	3	grained	grained	JJ
cord-301128-woe6knpv	168	4	model	model	NN
cord-301128-woe6knpv	168	5	of	of	IN
cord-301128-woe6knpv	168	6	the	the	DT
cord-301128-woe6knpv	168	7	demixing	demixing	NN
cord-301128-woe6knpv	168	8	of	of	IN
cord-301128-woe6knpv	168	9	DNA	dna	NN
cord-301128-woe6knpv	168	10	and	and	CC
cord-301128-woe6knpv	168	11	non	non	JJ
cord-301128-woe6knpv	168	12	-	-	JJ
cord-301128-woe6knpv	168	13	binding	binding	JJ
cord-301128-woe6knpv	168	14	globular	globular	JJ
cord-301128-woe6knpv	168	15	macromolecules	macromolecule	NNS
cord-301128-woe6knpv	169	1	A	a	DT
cord-301128-woe6knpv	169	2	segregative	segregative	JJ
cord-301128-woe6knpv	169	3	phase	phase	NN
cord-301128-woe6knpv	169	4	separation	separation	NN
cord-301128-woe6knpv	169	5	scenario	scenario	NN
cord-301128-woe6knpv	169	6	of	of	IN
cord-301128-woe6knpv	169	7	the	the	DT
cord-301128-woe6knpv	169	8	formation	formation	NN
cord-301128-woe6knpv	169	9	of	of	IN
cord-301128-woe6knpv	169	10	the	the	DT
cord-301128-woe6knpv	169	11	bacterial	bacterial	JJ
cord-301128-woe6knpv	169	12	nucleoid	nucleoid	NN
cord-301128-woe6knpv	169	13	Preferential	preferential	JJ
cord-301128-woe6knpv	169	14	localization	localization	NN
cord-301128-woe6knpv	169	15	of	of	IN
cord-301128-woe6knpv	169	16	the	the	DT
cord-301128-woe6knpv	169	17	bacterial	bacterial	JJ
cord-301128-woe6knpv	169	18	nucleoid	nucleoid	JJ
cord-301128-woe6knpv	169	19	Bacterial	bacterial	JJ
cord-301128-woe6knpv	169	20	nucleoid	nucleoid	NN
cord-301128-woe6knpv	169	21	:	:	:
cord-301128-woe6knpv	169	22	Interplay	interplay	NN
cord-301128-woe6knpv	169	23	of	of	IN
cord-301128-woe6knpv	169	24	DNA	dna	NN
cord-301128-woe6knpv	169	25	demixing	demixing	NN
cord-301128-woe6knpv	169	26	and	and	CC
cord-301128-woe6knpv	169	27	supercoiling	supercoile	VBG
cord-301128-woe6knpv	169	28	Kinetics	Kinetics	NNP
cord-301128-woe6knpv	169	29	of	of	IN
cord-301128-woe6knpv	169	30	DNA	DNA	NNP
cord-301128-woe6knpv	169	31	supercoiling	supercoiling	NN
cord-301128-woe6knpv	169	32	studied	study	VBN
cord-301128-woe6knpv	169	33	by	by	IN
cord-301128-woe6knpv	169	34	Brownian	Brownian	NNP
cord-301128-woe6knpv	169	35	dynamics	dynamic	NNS
cord-301128-woe6knpv	169	36	simulation	simulation	NN
cord-301128-woe6knpv	169	37	Structure	Structure	NNP
cord-301128-woe6knpv	169	38	of	of	IN
cord-301128-woe6knpv	169	39	plectonemically	plectonemically	RB
cord-301128-woe6knpv	169	40	supercoiled	supercoiled	JJ
cord-301128-woe6knpv	169	41	DNA	DNA	NNP
cord-301128-woe6knpv	169	42	Dynamics	Dynamics	NNPS
cord-301128-woe6knpv	169	43	of	of	IN
cord-301128-woe6knpv	169	44	the	the	DT
cord-301128-woe6knpv	169	45	buckling	buckle	VBG
cord-301128-woe6knpv	169	46	transition	transition	NN
cord-301128-woe6knpv	169	47	in	in	IN
cord-301128-woe6knpv	169	48	double	double	RB
cord-301128-woe6knpv	169	49	-	-	HYPH
cord-301128-woe6knpv	169	50	stranded	stranded	JJ
cord-301128-woe6knpv	169	51	DNA	DNA	NNP
cord-301128-woe6knpv	169	52	and	and	CC
cord-301128-woe6knpv	169	53	RNA	RNA	NNP
cord-301128-woe6knpv	169	54	Influence	Influence	NNP
cord-301128-woe6knpv	169	55	of	of	IN
cord-301128-woe6knpv	169	56	nucleoid	nucleoid	JJ
cord-301128-woe6knpv	169	57	-	-	HYPH
cord-301128-woe6knpv	169	58	associated	associate	VBN
cord-301128-woe6knpv	169	59	proteins	protein	NNS
cord-301128-woe6knpv	169	60	on	on	IN
cord-301128-woe6knpv	169	61	DNA	dna	NN
cord-301128-woe6knpv	169	62	supercoiling	supercoiling	NNP
cord-301128-woe6knpv	169	63	Simulation	Simulation	NNP
cord-301128-woe6knpv	169	64	of	of	IN
cord-301128-woe6knpv	169	65	DNA	DNA	NNP
cord-301128-woe6knpv	170	1	supercoil	supercoil	NNP
cord-301128-woe6knpv	170	2	relaxation	relaxation	NN
cord-301128-woe6knpv	170	3	Competition	Competition	NNP
cord-301128-woe6knpv	170	4	between	between	IN
cord-301128-woe6knpv	170	5	B	b	NN
cord-301128-woe6knpv	170	6	-	-	HYPH
cord-301128-woe6knpv	170	7	Z	Z	NNP
cord-301128-woe6knpv	170	8	and	and	CC
cord-301128-woe6knpv	170	9	B	B	NNP
cord-301128-woe6knpv	170	10	-	-	HYPH
cord-301128-woe6knpv	170	11	L	l	NN
cord-301128-woe6knpv	170	12	transitions	transition	NNS
cord-301128-woe6knpv	170	13	in	in	IN
cord-301128-woe6knpv	170	14	a	a	DT
cord-301128-woe6knpv	170	15	single	single	JJ
cord-301128-woe6knpv	170	16	DNA	dna	NN
cord-301128-woe6knpv	170	17	molecule	molecule	NN
cord-301128-woe6knpv	170	18	:	:	:
cord-301128-woe6knpv	171	1	Computational	computational	JJ
cord-301128-woe6knpv	171	2	studies	study	NNS
cord-301128-woe6knpv	172	1	A	a	DT
cord-301128-woe6knpv	172	2	multiscale	multiscale	JJ
cord-301128-woe6knpv	172	3	dynamic	dynamic	JJ
cord-301128-woe6knpv	172	4	model	model	NN
cord-301128-woe6knpv	172	5	of	of	IN
cord-301128-woe6knpv	172	6	DNA	dna	NN
cord-301128-woe6knpv	172	7	supercoil	supercoil	NN
cord-301128-woe6knpv	172	8	relaxation	relaxation	NN
cord-301128-woe6knpv	172	9	by	by	IN
cord-301128-woe6knpv	172	10	topoisomerase	topoisomerase	NN
cord-301128-woe6knpv	172	11	IB	IB	NNP
cord-301128-woe6knpv	172	12	Brownian	Brownian	NNP
cord-301128-woe6knpv	172	13	dynamics	dynamic	NNS
cord-301128-woe6knpv	172	14	simulations	simulation	NNS
cord-301128-woe6knpv	172	15	of	of	IN
cord-301128-woe6knpv	172	16	sequence	sequence	NN
cord-301128-woe6knpv	172	17	-	-	HYPH
cord-301128-woe6knpv	172	18	dependent	dependent	JJ
cord-301128-woe6knpv	172	19	duplex	duplex	NN
cord-301128-woe6knpv	172	20	denaturation	denaturation	NN
cord-301128-woe6knpv	172	21	in	in	IN
cord-301128-woe6knpv	172	22	dynamically	dynamically	RB
cord-301128-woe6knpv	172	23	superhelical	superhelical	JJ
cord-301128-woe6knpv	172	24	DNA	DNA	NNP
cord-301128-woe6knpv	172	25	Transcription	Transcription	NNP
cord-301128-woe6knpv	172	26	-	-	HYPH
cord-301128-woe6knpv	172	27	driven	drive	VBN
cord-301128-woe6knpv	172	28	twin	twin	JJ
cord-301128-woe6knpv	172	29	supercoiling	supercoiling	NN
cord-301128-woe6knpv	172	30	of	of	IN
cord-301128-woe6knpv	172	31	a	a	DT
cord-301128-woe6knpv	172	32	DNA	dna	NN
cord-301128-woe6knpv	172	33	loop	loop	NN
cord-301128-woe6knpv	172	34	:	:	:
cord-301128-woe6knpv	173	1	A	a	DT
cord-301128-woe6knpv	173	2	Brownian	Brownian	NNP
cord-301128-woe6knpv	173	3	dynamics	dynamic	NNS
cord-301128-woe6knpv	173	4	study	study	NN
cord-301128-woe6knpv	173	5	Dynamics	dynamic	NNS
cord-301128-woe6knpv	173	6	of	of	IN
cord-301128-woe6knpv	173	7	site	site	NN
cord-301128-woe6knpv	173	8	juxtaposition	juxtaposition	NN
cord-301128-woe6knpv	173	9	in	in	IN
cord-301128-woe6knpv	173	10	supercoiled	supercoiled	JJ
cord-301128-woe6knpv	173	11	DNA	DNA	NNP
cord-301128-woe6knpv	173	12	Salt	Salt	NNP
cord-301128-woe6knpv	173	13	effects	effect	NNS
cord-301128-woe6knpv	173	14	on	on	IN
cord-301128-woe6knpv	173	15	the	the	DT
cord-301128-woe6knpv	173	16	structure	structure	NN
cord-301128-woe6knpv	173	17	and	and	CC
cord-301128-woe6knpv	173	18	internal	internal	JJ
cord-301128-woe6knpv	173	19	dynamics	dynamic	NNS
cord-301128-woe6knpv	173	20	of	of	IN
cord-301128-woe6knpv	173	21	superhelical	superhelical	JJ
cord-301128-woe6knpv	173	22	DNAs	dna	NNS
cord-301128-woe6knpv	173	23	studied	study	VBN
cord-301128-woe6knpv	173	24	by	by	IN
cord-301128-woe6knpv	173	25	light	light	JJ
cord-301128-woe6knpv	173	26	scattering	scattering	NN
cord-301128-woe6knpv	173	27	and	and	CC
cord-301128-woe6knpv	173	28	Brownian	Brownian	NNP
cord-301128-woe6knpv	173	29	dynamics	dynamic	NNS
cord-301128-woe6knpv	174	1	Limiting	limit	VBG
cord-301128-woe6knpv	174	2	laws	law	NNS
cord-301128-woe6knpv	174	3	and	and	CC
cord-301128-woe6knpv	174	4	counterion	counterion	NN
cord-301128-woe6knpv	174	5	condensation	condensation	NN
cord-301128-woe6knpv	174	6	in	in	IN
cord-301128-woe6knpv	174	7	polyelectrolyte	polyelectrolyte	NNP
cord-301128-woe6knpv	174	8	solutions	solution	NNS
cord-301128-woe6knpv	174	9	.	.	.
cord-301128-woe6knpv	175	1	I.	I.	NNP
cord-301128-woe6knpv	175	2	Colligative	Colligative	NNP
cord-301128-woe6knpv	175	3	properties	property	NNS
cord-301128-woe6knpv	176	1	Polyelectrolytes	polyelectrolyte	NNS
cord-301128-woe6knpv	176	2	.	.	.
cord-301128-woe6knpv	177	1	Marcel	Marcel	NNP
cord-301128-woe6knpv	177	2	Dekker	Dekker	NNP
cord-301128-woe6knpv	177	3	Use	Use	NNP
cord-301128-woe6knpv	177	4	of	of	IN
cord-301128-woe6knpv	177	5	site	site	NN
cord-301128-woe6knpv	177	6	-	-	HYPH
cord-301128-woe6knpv	177	7	specific	specific	JJ
cord-301128-woe6knpv	177	8	recombination	recombination	NN
cord-301128-woe6knpv	177	9	as	as	IN
cord-301128-woe6knpv	177	10	a	a	DT
cord-301128-woe6knpv	177	11	probe	probe	NN
cord-301128-woe6knpv	177	12	of	of	IN
cord-301128-woe6knpv	177	13	DNA	dna	NN
cord-301128-woe6knpv	177	14	structure	structure	NN
cord-301128-woe6knpv	177	15	and	and	CC
cord-301128-woe6knpv	177	16	metabolism	metabolism	NN
cord-301128-woe6knpv	177	17	in	in	IN
cord-301128-woe6knpv	177	18	vivo	vivo	NNP
cord-301128-woe6knpv	177	19	Structure	structure	NN
cord-301128-woe6knpv	177	20	and	and	CC
cord-301128-woe6knpv	177	21	reactions	reaction	NNS
cord-301128-woe6knpv	177	22	of	of	IN
cord-301128-woe6knpv	177	23	closed	closed	JJ
cord-301128-woe6knpv	177	24	duplex	duplex	JJ
cord-301128-woe6knpv	177	25	DNA	dna	NN
cord-301128-woe6knpv	177	26	DNA	dna	NN
cord-301128-woe6knpv	177	27	gyrase	gyrase	NN
cord-301128-woe6knpv	177	28	:	:	:
cord-301128-woe6knpv	178	1	structure	structure	NN
cord-301128-woe6knpv	178	2	and	and	CC
cord-301128-woe6knpv	178	3	function	function	VB
cord-301128-woe6knpv	178	4	Transcription	transcription	NN
cord-301128-woe6knpv	178	5	-	-	HYPH
cord-301128-woe6knpv	178	6	coupled	couple	VBN
cord-301128-woe6knpv	178	7	hypernegative	hypernegative	NNP
cord-301128-woe6knpv	178	8	supercoiling	supercoiling	NN
cord-301128-woe6knpv	178	9	of	of	IN
cord-301128-woe6knpv	178	10	plasmid	plasmid	NN
cord-301128-woe6knpv	178	11	DNA	dna	NN
cord-301128-woe6knpv	178	12	by	by	IN
cord-301128-woe6knpv	178	13	T7	T7	NNP
cord-301128-woe6knpv	178	14	RNA	RNA	NNP
cord-301128-woe6knpv	178	15	polymerase	polymerase	NN
cord-301128-woe6knpv	178	16	in	in	IN
cord-301128-woe6knpv	178	17	Escherichia	Escherichia	NNP
cord-301128-woe6knpv	178	18	coli	coli	NNS
cord-301128-woe6knpv	179	1	topoisomerase	topoisomerase	NN
cord-301128-woe6knpv	179	2	I	i	NN
cord-301128-woe6knpv	179	3	-	-	HYPH
cord-301128-woe6knpv	179	4	deficient	deficient	JJ
cord-301128-woe6knpv	179	5	strains	strain	NNS
cord-301128-woe6knpv	180	1	Potent	potent	JJ
cord-301128-woe6knpv	180	2	stimulation	stimulation	NN
cord-301128-woe6knpv	180	3	of	of	IN
cord-301128-woe6knpv	180	4	transcription	transcription	NN
cord-301128-woe6knpv	180	5	-	-	HYPH
cord-301128-woe6knpv	180	6	coupled	couple	VBN
cord-301128-woe6knpv	180	7	DNA	dna	NN
cord-301128-woe6knpv	180	8	supercoiling	supercoiling	NN
cord-301128-woe6knpv	180	9	by	by	IN
cord-301128-woe6knpv	180	10	sequence	sequence	NN
cord-301128-woe6knpv	180	11	-	-	HYPH
cord-301128-woe6knpv	180	12	specific	specific	JJ
cord-301128-woe6knpv	180	13	DNA	dna	NN
cord-301128-woe6knpv	180	14	-	-	HYPH
cord-301128-woe6knpv	180	15	binding	bind	VBG
cord-301128-woe6knpv	180	16	proteins	protein	NNS
cord-301128-woe6knpv	180	17	Large	large	JJ
cord-301128-woe6knpv	180	18	-	-	HYPH
cord-301128-woe6knpv	180	19	scale	scale	NN
cord-301128-woe6knpv	180	20	conformational	conformational	JJ
cord-301128-woe6knpv	180	21	transitions	transition	NNS
cord-301128-woe6knpv	180	22	in	in	IN
cord-301128-woe6knpv	180	23	supercoiled	supercoiled	JJ
cord-301128-woe6knpv	180	24	DNA	DNA	NNP
cord-301128-woe6knpv	180	25	revealed	reveal	VBN
cord-301128-woe6knpv	180	26	by	by	IN
cord-301128-woe6knpv	180	27	coarse	coarse	RB
cord-301128-woe6knpv	180	28	-	-	HYPH
cord-301128-woe6knpv	180	29	grained	grained	JJ
cord-301128-woe6knpv	180	30	simulation	simulation	NN
cord-301128-woe6knpv	180	31	Hyperplectonemes	Hyperplectonemes	NNP
cord-301128-woe6knpv	180	32	:	:	:
cord-301128-woe6knpv	181	1	A	a	DT
cord-301128-woe6knpv	181	2	higher	high	JJR
cord-301128-woe6knpv	181	3	order	order	NN
cord-301128-woe6knpv	181	4	compact	compact	JJ
cord-301128-woe6knpv	181	5	and	and	CC
cord-301128-woe6knpv	181	6	dynamic	dynamic	JJ
cord-301128-woe6knpv	181	7	DNA	dna	NN
cord-301128-woe6knpv	181	8	self	self	NN
cord-301128-woe6knpv	181	9	-	-	HYPH
cord-301128-woe6knpv	181	10	organization	organization	NN
cord-301128-woe6knpv	181	11	Viscous	viscous	JJ
cord-301128-woe6knpv	181	12	nonlinear	nonlinear	JJ
cord-301128-woe6knpv	181	13	dynamics	dynamic	NNS
cord-301128-woe6knpv	181	14	of	of	IN
cord-301128-woe6knpv	181	15	twist	twist	NN
cord-301128-woe6knpv	181	16	and	and	CC
cord-301128-woe6knpv	181	17	writhe	writhe	VBP
cord-301128-woe6knpv	181	18	Twist	twist	VB
cord-301128-woe6knpv	181	19	and	and	CC
cord-301128-woe6knpv	181	20	writhe	writhe	VBP
cord-301128-woe6knpv	181	21	dynamics	dynamic	NNS
cord-301128-woe6knpv	181	22	of	of	IN
cord-301128-woe6knpv	181	23	stiff	stiff	JJ
cord-301128-woe6knpv	181	24	polymers	polymer	NNS
cord-301128-woe6knpv	181	25	Structural	structural	JJ
cord-301128-woe6knpv	181	26	basis	basis	NN
cord-301128-woe6knpv	181	27	for	for	IN
cord-301128-woe6knpv	181	28	recognition	recognition	NN
cord-301128-woe6knpv	181	29	of	of	IN
cord-301128-woe6knpv	181	30	AT	at	NN
cord-301128-woe6knpv	181	31	-	-	HYPH
cord-301128-woe6knpv	181	32	rich	rich	JJ
cord-301128-woe6knpv	181	33	DNA	dna	NN
cord-301128-woe6knpv	181	34	by	by	IN
cord-301128-woe6knpv	181	35	unrelated	unrelated	JJ
cord-301128-woe6knpv	181	36	xenogeneic	xenogeneic	NNS
cord-301128-woe6knpv	181	37	silencing	silence	VBG
cord-301128-woe6knpv	181	38	proteins	protein	NNS
cord-301128-woe6knpv	181	39	Domain	Domain	NNP
cord-301128-woe6knpv	181	40	organization	organization	NN
cord-301128-woe6knpv	181	41	and	and	CC
cord-301128-woe6knpv	181	42	oligomerization	oligomerization	NN
cord-301128-woe6knpv	181	43	among	among	IN
cord-301128-woe6knpv	181	44	H	H	NNP
cord-301128-woe6knpv	181	45	-	-	HYPH
cord-301128-woe6knpv	181	46	NS	NS	NNP
cord-301128-woe6knpv	181	47	like	like	IN
cord-301128-woe6knpv	181	48	nucleoid	nucleoid	NN
cord-301128-woe6knpv	181	49	-	-	HYPH
cord-301128-woe6knpv	181	50	associated	associate	VBN
cord-301128-woe6knpv	181	51	proteins	protein	NNS
cord-301128-woe6knpv	181	52	in	in	IN
cord-301128-woe6knpv	181	53	bacteria	bacteria	NNS
cord-301128-woe6knpv	181	54	Protein	Protein	NNP
cord-301128-woe6knpv	181	55	occupancy	occupancy	NN
cord-301128-woe6knpv	181	56	landscape	landscape	NN
cord-301128-woe6knpv	181	57	of	of	IN
cord-301128-woe6knpv	181	58	a	a	DT
cord-301128-woe6knpv	181	59	bacterial	bacterial	JJ
cord-301128-woe6knpv	181	60	genome	genome	NN
cord-301128-woe6knpv	181	61	Fis	Fis	NNP
cord-301128-woe6knpv	181	62	protein	protein	NN
cord-301128-woe6knpv	181	63	forms	form	VBZ
cord-301128-woe6knpv	181	64	DNA	dna	NN
cord-301128-woe6knpv	181	65	topological	topological	JJ
cord-301128-woe6knpv	181	66	barriers	barrier	NNS
cord-301128-woe6knpv	181	67	to	to	TO
cord-301128-woe6knpv	181	68	confine	confine	VB
cord-301128-woe6knpv	181	69	transcription	transcription	NN
cord-301128-woe6knpv	181	70	-	-	HYPH
cord-301128-woe6knpv	181	71	coupled	couple	VBN
cord-301128-woe6knpv	181	72	DNA	dna	NN
cord-301128-woe6knpv	181	73	supercoiling	supercoiling	NN
cord-301128-woe6knpv	181	74	in	in	IN
cord-301128-woe6knpv	181	75	Escherichia	Escherichia	NNP
cord-301128-woe6knpv	181	76	coli	coli	VBZ
cord-301128-woe6knpv	181	77	Genes	gene	NNS
cord-301128-woe6knpv	181	78	on	on	IN
cord-301128-woe6knpv	181	79	a	a	DT
cord-301128-woe6knpv	181	80	wire	wire	NN
cord-301128-woe6knpv	182	1	:	:	:
cord-301128-woe6knpv	182	2	The	the	DT
cord-301128-woe6knpv	182	3	nucleoid	nucleoid	RB
cord-301128-woe6knpv	182	4	-	-	HYPH
cord-301128-woe6knpv	182	5	associated	associate	VBN
cord-301128-woe6knpv	182	6	protein	protein	NN
cord-301128-woe6knpv	182	7	HU	HU	NNP
cord-301128-woe6knpv	182	8	insulates	insulate	VBZ
cord-301128-woe6knpv	182	9	transcription	transcription	NN
cord-301128-woe6knpv	182	10	units	unit	NNS
cord-301128-woe6knpv	182	11	in	in	IN
cord-301128-woe6knpv	182	12	Escherichia	Escherichia	NNP
cord-301128-woe6knpv	182	13	coli	coli	NNS
cord-301128-woe6knpv	182	14	Shape	shape	NN
cord-301128-woe6knpv	182	15	and	and	CC
cord-301128-woe6knpv	182	16	compaction	compaction	NN
cord-301128-woe6knpv	182	17	of	of	IN
cord-301128-woe6knpv	182	18	Escherichia	Escherichia	NNP
cord-301128-woe6knpv	182	19	coli	coli	NNS
cord-301128-woe6knpv	182	20	nucleoids	nucleoid	NNS
cord-301128-woe6knpv	182	21	DNA	DNA	NNP
cord-301128-woe6knpv	182	22	condensation	condensation	NN
cord-301128-woe6knpv	182	23	in	in	IN
cord-301128-woe6knpv	182	24	bacteria	bacteria	NNS
cord-301128-woe6knpv	182	25	:	:	:
cord-301128-woe6knpv	182	26	Interplay	interplay	NN
cord-301128-woe6knpv	182	27	between	between	IN
cord-301128-woe6knpv	182	28	macromolecular	macromolecular	JJ
cord-301128-woe6knpv	182	29	crowding	crowding	NN
cord-301128-woe6knpv	182	30	and	and	CC
cord-301128-woe6knpv	182	31	nucleoid	nucleoid	NNP
cord-301128-woe6knpv	182	32	proteins	protein	NNS
cord-301128-woe6knpv	183	1	Physical	physical	JJ
cord-301128-woe6knpv	183	2	descriptions	description	NNS
cord-301128-woe6knpv	183	3	of	of	IN
cord-301128-woe6knpv	183	4	the	the	DT
cord-301128-woe6knpv	183	5	bacterial	bacterial	JJ
cord-301128-woe6knpv	183	6	nucleoid	nucleoid	NN
cord-301128-woe6knpv	183	7	at	at	IN
cord-301128-woe6knpv	183	8	large	large	JJ
cord-301128-woe6knpv	183	9	scales	scale	NNS
cord-301128-woe6knpv	183	10	,	,	,
cord-301128-woe6knpv	183	11	and	and	CC
cord-301128-woe6knpv	183	12	their	-PRON-	PRP$
cord-301128-woe6knpv	183	13	biological	biological	JJ
cord-301128-woe6knpv	183	14	implications	implication	NNS
cord-301128-woe6knpv	183	15	From	from	IN
cord-301128-woe6knpv	183	16	structure	structure	NN
cord-301128-woe6knpv	183	17	to	to	IN
cord-301128-woe6knpv	183	18	function	function	NN
cord-301128-woe6knpv	183	19	of	of	IN
cord-301128-woe6knpv	183	20	bacterial	bacterial	JJ
cord-301128-woe6knpv	183	21	chromosomes	chromosome	NNS
cord-301128-woe6knpv	183	22	:	:	:
cord-301128-woe6knpv	183	23	Evolutionary	evolutionary	JJ
cord-301128-woe6knpv	183	24	perspectives	perspective	NNS
cord-301128-woe6knpv	183	25	and	and	CC
cord-301128-woe6knpv	183	26	ideas	idea	NNS
cord-301128-woe6knpv	183	27	for	for	IN
cord-301128-woe6knpv	183	28	new	new	JJ
cord-301128-woe6knpv	183	29	experiments	experiment	NNS
cord-301128-woe6knpv	183	30	Polymer	Polymer	NNP
cord-301128-woe6knpv	183	31	solutions	solution	NNS
cord-301128-woe6knpv	183	32	:	:	:
cord-301128-woe6knpv	183	33	An	an	DT
cord-301128-woe6knpv	183	34	introduction	introduction	NN
cord-301128-woe6knpv	183	35	to	to	IN
cord-301128-woe6knpv	183	36	physical	physical	JJ
cord-301128-woe6knpv	183	37	properties	property	NNS
cord-301128-woe6knpv	184	1	A	a	DT
cord-301128-woe6knpv	184	2	combined	combined	JJ
cord-301128-woe6knpv	184	3	wormlike	wormlike	JJ
cord-301128-woe6knpv	184	4	-	-	HYPH
cord-301128-woe6knpv	184	5	chain	chain	NN
cord-301128-woe6knpv	184	6	and	and	CC
cord-301128-woe6knpv	184	7	bead	bead	NN
cord-301128-woe6knpv	184	8	model	model	NN
cord-301128-woe6knpv	184	9	for	for	IN
cord-301128-woe6knpv	184	10	dynamic	dynamic	JJ
cord-301128-woe6knpv	184	11	simulations	simulation	NNS
cord-301128-woe6knpv	184	12	of	of	IN
cord-301128-woe6knpv	184	13	long	long	JJ
cord-301128-woe6knpv	184	14	linear	linear	JJ
cord-301128-woe6knpv	184	15	DNA	DNA	NNP
cord-301128-woe6knpv	184	16	Conformational	Conformational	NNP
cord-301128-woe6knpv	184	17	and	and	CC
cord-301128-woe6knpv	184	18	thermodynamic	thermodynamic	JJ
cord-301128-woe6knpv	184	19	properties	property	NNS
cord-301128-woe6knpv	184	20	of	of	IN
cord-301128-woe6knpv	184	21	supercoiled	supercoiled	JJ
cord-301128-woe6knpv	184	22	DNA	DNA	NNP
cord-301128-woe6knpv	184	23	References	References	NNPS
cord-301128-woe6knpv	184	24	(	(	-LRB-
cord-301128-woe6knpv	184	25	70,71	70,71	CD
cord-301128-woe6knpv	184	26	)	)	-RRB-
cord-301128-woe6knpv	184	27	 	 	_SP